data_8YKK
# 
_entry.id   8YKK 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YKK         pdb_00008ykk 10.2210/pdb8ykk/pdb 
WWPDB D_1300043862 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YKK 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhou, X.L.' 1 ? 
'Lin, C.'    2 ? 
'Zhang, J.'  3 ? 
'Li, J.'     4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            276 
_citation.language                  ? 
_citation.page_first                133706 
_citation.page_last                 133706 
_citation.title                     
'Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.133706 
_citation.pdbx_database_id_PubMed   38981557 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, H.' 1 ? 
primary 'Li, W.'    2 ? 
primary 'Zhou, X.'  3 ? 
primary 'Zhang, J.' 4 ? 
primary 'Li, J.'    5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                                    
33066.754 1  3.4.22.69 ? ? ? 
2 non-polymer syn 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' 
459.583   1  ?         ? ? ? 
3 water       nat water                                                                                                        
18.015    20 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHS
MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHS
MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' X77 
3 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PHE n 
1 3   ARG n 
1 4   LYS n 
1 5   MET n 
1 6   ALA n 
1 7   PHE n 
1 8   PRO n 
1 9   SER n 
1 10  GLY n 
1 11  LYS n 
1 12  VAL n 
1 13  GLU n 
1 14  GLY n 
1 15  CYS n 
1 16  MET n 
1 17  VAL n 
1 18  GLN n 
1 19  VAL n 
1 20  THR n 
1 21  CYS n 
1 22  GLY n 
1 23  THR n 
1 24  THR n 
1 25  THR n 
1 26  LEU n 
1 27  ASN n 
1 28  GLY n 
1 29  LEU n 
1 30  TRP n 
1 31  LEU n 
1 32  ASP n 
1 33  ASP n 
1 34  THR n 
1 35  VAL n 
1 36  TYR n 
1 37  CYS n 
1 38  PRO n 
1 39  ARG n 
1 40  HIS n 
1 41  VAL n 
1 42  ILE n 
1 43  CYS n 
1 44  THR n 
1 45  ALA n 
1 46  GLU n 
1 47  ASP n 
1 48  MET n 
1 49  LEU n 
1 50  ASN n 
1 51  PRO n 
1 52  ASN n 
1 53  TYR n 
1 54  GLU n 
1 55  ASP n 
1 56  LEU n 
1 57  LEU n 
1 58  ILE n 
1 59  ARG n 
1 60  LYS n 
1 61  SER n 
1 62  ASN n 
1 63  HIS n 
1 64  SER n 
1 65  PHE n 
1 66  LEU n 
1 67  VAL n 
1 68  GLN n 
1 69  ALA n 
1 70  GLY n 
1 71  ASN n 
1 72  VAL n 
1 73  GLN n 
1 74  LEU n 
1 75  ARG n 
1 76  VAL n 
1 77  ILE n 
1 78  GLY n 
1 79  HIS n 
1 80  SER n 
1 81  MET n 
1 82  GLN n 
1 83  ASN n 
1 84  CYS n 
1 85  LEU n 
1 86  LEU n 
1 87  ARG n 
1 88  LEU n 
1 89  LYS n 
1 90  VAL n 
1 91  ASP n 
1 92  THR n 
1 93  SER n 
1 94  ASN n 
1 95  PRO n 
1 96  LYS n 
1 97  THR n 
1 98  PRO n 
1 99  LYS n 
1 100 TYR n 
1 101 LYS n 
1 102 PHE n 
1 103 VAL n 
1 104 ARG n 
1 105 ILE n 
1 106 GLN n 
1 107 PRO n 
1 108 GLY n 
1 109 GLN n 
1 110 THR n 
1 111 PHE n 
1 112 SER n 
1 113 VAL n 
1 114 LEU n 
1 115 ALA n 
1 116 CYS n 
1 117 TYR n 
1 118 ASN n 
1 119 GLY n 
1 120 SER n 
1 121 PRO n 
1 122 SER n 
1 123 GLY n 
1 124 VAL n 
1 125 TYR n 
1 126 GLN n 
1 127 CYS n 
1 128 ALA n 
1 129 MET n 
1 130 ARG n 
1 131 PRO n 
1 132 ASN n 
1 133 HIS n 
1 134 THR n 
1 135 ILE n 
1 136 LYS n 
1 137 GLY n 
1 138 SER n 
1 139 PHE n 
1 140 LEU n 
1 141 ASN n 
1 142 GLY n 
1 143 SER n 
1 144 CYS n 
1 145 GLY n 
1 146 SER n 
1 147 VAL n 
1 148 GLY n 
1 149 PHE n 
1 150 ASN n 
1 151 ILE n 
1 152 ASP n 
1 153 TYR n 
1 154 ASP n 
1 155 CYS n 
1 156 VAL n 
1 157 SER n 
1 158 PHE n 
1 159 CYS n 
1 160 TYR n 
1 161 MET n 
1 162 HIS n 
1 163 HIS n 
1 164 MET n 
1 165 GLU n 
1 166 LEU n 
1 167 PRO n 
1 168 THR n 
1 169 GLY n 
1 170 VAL n 
1 171 HIS n 
1 172 ALA n 
1 173 GLY n 
1 174 THR n 
1 175 ASP n 
1 176 LEU n 
1 177 GLU n 
1 178 GLY n 
1 179 LYS n 
1 180 PHE n 
1 181 TYR n 
1 182 GLY n 
1 183 PRO n 
1 184 PHE n 
1 185 VAL n 
1 186 ASP n 
1 187 ARG n 
1 188 GLN n 
1 189 THR n 
1 190 ALA n 
1 191 GLN n 
1 192 ALA n 
1 193 ALA n 
1 194 GLY n 
1 195 THR n 
1 196 ASP n 
1 197 THR n 
1 198 THR n 
1 199 ILE n 
1 200 THR n 
1 201 LEU n 
1 202 ASN n 
1 203 VAL n 
1 204 LEU n 
1 205 ALA n 
1 206 TRP n 
1 207 LEU n 
1 208 TYR n 
1 209 ALA n 
1 210 ALA n 
1 211 VAL n 
1 212 ILE n 
1 213 ASN n 
1 214 GLY n 
1 215 ASP n 
1 216 ARG n 
1 217 TRP n 
1 218 PHE n 
1 219 LEU n 
1 220 ASN n 
1 221 ARG n 
1 222 PHE n 
1 223 THR n 
1 224 THR n 
1 225 THR n 
1 226 LEU n 
1 227 ASN n 
1 228 ASP n 
1 229 PHE n 
1 230 ASN n 
1 231 LEU n 
1 232 VAL n 
1 233 ALA n 
1 234 MET n 
1 235 LYS n 
1 236 TYR n 
1 237 ASN n 
1 238 TYR n 
1 239 GLU n 
1 240 PRO n 
1 241 LEU n 
1 242 THR n 
1 243 GLN n 
1 244 ASP n 
1 245 HIS n 
1 246 VAL n 
1 247 ASP n 
1 248 ILE n 
1 249 LEU n 
1 250 GLY n 
1 251 PRO n 
1 252 LEU n 
1 253 SER n 
1 254 ALA n 
1 255 GLN n 
1 256 THR n 
1 257 GLY n 
1 258 ILE n 
1 259 ALA n 
1 260 VAL n 
1 261 LEU n 
1 262 ASP n 
1 263 MET n 
1 264 CYS n 
1 265 ALA n 
1 266 ALA n 
1 267 LEU n 
1 268 LYS n 
1 269 GLU n 
1 270 LEU n 
1 271 LEU n 
1 272 GLN n 
1 273 ASN n 
1 274 GLY n 
1 275 MET n 
1 276 ASN n 
1 277 GLY n 
1 278 ARG n 
1 279 THR n 
1 280 ILE n 
1 281 LEU n 
1 282 GLY n 
1 283 SER n 
1 284 THR n 
1 285 ILE n 
1 286 LEU n 
1 287 GLU n 
1 288 ASP n 
1 289 GLU n 
1 290 PHE n 
1 291 THR n 
1 292 PRO n 
1 293 PHE n 
1 294 ASP n 
1 295 VAL n 
1 296 VAL n 
1 297 ARG n 
1 298 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   298 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome-related coronavirus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     694009 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
X77 non-polymer         . 
'N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide' ? 'C27 H33 N5 O2'  
459.583 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   2   2   GLY GLY A . n 
A 1 2   PHE 2   3   3   PHE PHE A . n 
A 1 3   ARG 3   4   4   ARG ARG A . n 
A 1 4   LYS 4   5   5   LYS LYS A . n 
A 1 5   MET 5   6   6   MET MET A . n 
A 1 6   ALA 6   7   7   ALA ALA A . n 
A 1 7   PHE 7   8   8   PHE PHE A . n 
A 1 8   PRO 8   9   9   PRO PRO A . n 
A 1 9   SER 9   10  10  SER SER A . n 
A 1 10  GLY 10  11  11  GLY GLY A . n 
A 1 11  LYS 11  12  12  LYS LYS A . n 
A 1 12  VAL 12  13  13  VAL VAL A . n 
A 1 13  GLU 13  14  14  GLU GLU A . n 
A 1 14  GLY 14  15  15  GLY GLY A . n 
A 1 15  CYS 15  16  16  CYS CYS A . n 
A 1 16  MET 16  17  17  MET MET A . n 
A 1 17  VAL 17  18  18  VAL VAL A . n 
A 1 18  GLN 18  19  19  GLN GLN A . n 
A 1 19  VAL 19  20  20  VAL VAL A . n 
A 1 20  THR 20  21  21  THR THR A . n 
A 1 21  CYS 21  22  22  CYS CYS A . n 
A 1 22  GLY 22  23  23  GLY GLY A . n 
A 1 23  THR 23  24  24  THR THR A . n 
A 1 24  THR 24  25  25  THR THR A . n 
A 1 25  THR 25  26  26  THR THR A . n 
A 1 26  LEU 26  27  27  LEU LEU A . n 
A 1 27  ASN 27  28  28  ASN ASN A . n 
A 1 28  GLY 28  29  29  GLY GLY A . n 
A 1 29  LEU 29  30  30  LEU LEU A . n 
A 1 30  TRP 30  31  31  TRP TRP A . n 
A 1 31  LEU 31  32  32  LEU LEU A . n 
A 1 32  ASP 32  33  33  ASP ASP A . n 
A 1 33  ASP 33  34  34  ASP ASP A . n 
A 1 34  THR 34  35  35  THR THR A . n 
A 1 35  VAL 35  36  36  VAL VAL A . n 
A 1 36  TYR 36  37  37  TYR TYR A . n 
A 1 37  CYS 37  38  38  CYS CYS A . n 
A 1 38  PRO 38  39  39  PRO PRO A . n 
A 1 39  ARG 39  40  40  ARG ARG A . n 
A 1 40  HIS 40  41  41  HIS HIS A . n 
A 1 41  VAL 41  42  42  VAL VAL A . n 
A 1 42  ILE 42  43  43  ILE ILE A . n 
A 1 43  CYS 43  44  44  CYS CYS A . n 
A 1 44  THR 44  45  45  THR THR A . n 
A 1 45  ALA 45  46  46  ALA ALA A . n 
A 1 46  GLU 46  47  47  GLU GLU A . n 
A 1 47  ASP 47  48  48  ASP ASP A . n 
A 1 48  MET 48  49  49  MET MET A . n 
A 1 49  LEU 49  50  50  LEU LEU A . n 
A 1 50  ASN 50  51  51  ASN ASN A . n 
A 1 51  PRO 51  52  52  PRO PRO A . n 
A 1 52  ASN 52  53  53  ASN ASN A . n 
A 1 53  TYR 53  54  54  TYR TYR A . n 
A 1 54  GLU 54  55  55  GLU GLU A . n 
A 1 55  ASP 55  56  56  ASP ASP A . n 
A 1 56  LEU 56  57  57  LEU LEU A . n 
A 1 57  LEU 57  58  58  LEU LEU A . n 
A 1 58  ILE 58  59  59  ILE ILE A . n 
A 1 59  ARG 59  60  60  ARG ARG A . n 
A 1 60  LYS 60  61  61  LYS LYS A . n 
A 1 61  SER 61  62  62  SER SER A . n 
A 1 62  ASN 62  63  63  ASN ASN A . n 
A 1 63  HIS 63  64  64  HIS HIS A . n 
A 1 64  SER 64  65  65  SER SER A . n 
A 1 65  PHE 65  66  66  PHE PHE A . n 
A 1 66  LEU 66  67  67  LEU LEU A . n 
A 1 67  VAL 67  68  68  VAL VAL A . n 
A 1 68  GLN 68  69  69  GLN GLN A . n 
A 1 69  ALA 69  70  70  ALA ALA A . n 
A 1 70  GLY 70  71  71  GLY GLY A . n 
A 1 71  ASN 71  72  72  ASN ASN A . n 
A 1 72  VAL 72  73  73  VAL VAL A . n 
A 1 73  GLN 73  74  74  GLN GLN A . n 
A 1 74  LEU 74  75  75  LEU LEU A . n 
A 1 75  ARG 75  76  76  ARG ARG A . n 
A 1 76  VAL 76  77  77  VAL VAL A . n 
A 1 77  ILE 77  78  78  ILE ILE A . n 
A 1 78  GLY 78  79  79  GLY GLY A . n 
A 1 79  HIS 79  80  80  HIS HIS A . n 
A 1 80  SER 80  81  81  SER SER A . n 
A 1 81  MET 81  82  82  MET MET A . n 
A 1 82  GLN 82  83  83  GLN GLN A . n 
A 1 83  ASN 83  84  84  ASN ASN A . n 
A 1 84  CYS 84  85  85  CYS CYS A . n 
A 1 85  LEU 85  86  86  LEU LEU A . n 
A 1 86  LEU 86  87  87  LEU LEU A . n 
A 1 87  ARG 87  88  88  ARG ARG A . n 
A 1 88  LEU 88  89  89  LEU LEU A . n 
A 1 89  LYS 89  90  90  LYS LYS A . n 
A 1 90  VAL 90  91  91  VAL VAL A . n 
A 1 91  ASP 91  92  92  ASP ASP A . n 
A 1 92  THR 92  93  93  THR THR A . n 
A 1 93  SER 93  94  94  SER SER A . n 
A 1 94  ASN 94  95  95  ASN ASN A . n 
A 1 95  PRO 95  96  96  PRO PRO A . n 
A 1 96  LYS 96  97  97  LYS LYS A . n 
A 1 97  THR 97  98  98  THR THR A . n 
A 1 98  PRO 98  99  99  PRO PRO A . n 
A 1 99  LYS 99  100 100 LYS LYS A . n 
A 1 100 TYR 100 101 101 TYR TYR A . n 
A 1 101 LYS 101 102 102 LYS LYS A . n 
A 1 102 PHE 102 103 103 PHE PHE A . n 
A 1 103 VAL 103 104 104 VAL VAL A . n 
A 1 104 ARG 104 105 105 ARG ARG A . n 
A 1 105 ILE 105 106 106 ILE ILE A . n 
A 1 106 GLN 106 107 107 GLN GLN A . n 
A 1 107 PRO 107 108 108 PRO PRO A . n 
A 1 108 GLY 108 109 109 GLY GLY A . n 
A 1 109 GLN 109 110 110 GLN GLN A . n 
A 1 110 THR 110 111 111 THR THR A . n 
A 1 111 PHE 111 112 112 PHE PHE A . n 
A 1 112 SER 112 113 113 SER SER A . n 
A 1 113 VAL 113 114 114 VAL VAL A . n 
A 1 114 LEU 114 115 115 LEU LEU A . n 
A 1 115 ALA 115 116 116 ALA ALA A . n 
A 1 116 CYS 116 117 117 CYS CYS A . n 
A 1 117 TYR 117 118 118 TYR TYR A . n 
A 1 118 ASN 118 119 119 ASN ASN A . n 
A 1 119 GLY 119 120 120 GLY GLY A . n 
A 1 120 SER 120 121 121 SER SER A . n 
A 1 121 PRO 121 122 122 PRO PRO A . n 
A 1 122 SER 122 123 123 SER SER A . n 
A 1 123 GLY 123 124 124 GLY GLY A . n 
A 1 124 VAL 124 125 125 VAL VAL A . n 
A 1 125 TYR 125 126 126 TYR TYR A . n 
A 1 126 GLN 126 127 127 GLN GLN A . n 
A 1 127 CYS 127 128 128 CYS CYS A . n 
A 1 128 ALA 128 129 129 ALA ALA A . n 
A 1 129 MET 129 130 130 MET MET A . n 
A 1 130 ARG 130 131 131 ARG ARG A . n 
A 1 131 PRO 131 132 132 PRO PRO A . n 
A 1 132 ASN 132 133 133 ASN ASN A . n 
A 1 133 HIS 133 134 134 HIS HIS A . n 
A 1 134 THR 134 135 135 THR THR A . n 
A 1 135 ILE 135 136 136 ILE ILE A . n 
A 1 136 LYS 136 137 137 LYS LYS A . n 
A 1 137 GLY 137 138 138 GLY GLY A . n 
A 1 138 SER 138 139 139 SER SER A . n 
A 1 139 PHE 139 140 140 PHE PHE A . n 
A 1 140 LEU 140 141 141 LEU LEU A . n 
A 1 141 ASN 141 142 142 ASN ASN A . n 
A 1 142 GLY 142 143 143 GLY GLY A . n 
A 1 143 SER 143 144 144 SER SER A . n 
A 1 144 CYS 144 145 145 CYS CYS A . n 
A 1 145 GLY 145 146 146 GLY GLY A . n 
A 1 146 SER 146 147 147 SER SER A . n 
A 1 147 VAL 147 148 148 VAL VAL A . n 
A 1 148 GLY 148 149 149 GLY GLY A . n 
A 1 149 PHE 149 150 150 PHE PHE A . n 
A 1 150 ASN 150 151 151 ASN ASN A . n 
A 1 151 ILE 151 152 152 ILE ILE A . n 
A 1 152 ASP 152 153 153 ASP ASP A . n 
A 1 153 TYR 153 154 154 TYR TYR A . n 
A 1 154 ASP 154 155 155 ASP ASP A . n 
A 1 155 CYS 155 156 156 CYS CYS A . n 
A 1 156 VAL 156 157 157 VAL VAL A . n 
A 1 157 SER 157 158 158 SER SER A . n 
A 1 158 PHE 158 159 159 PHE PHE A . n 
A 1 159 CYS 159 160 160 CYS CYS A . n 
A 1 160 TYR 160 161 161 TYR TYR A . n 
A 1 161 MET 161 162 162 MET MET A . n 
A 1 162 HIS 162 163 163 HIS HIS A . n 
A 1 163 HIS 163 164 164 HIS HIS A . n 
A 1 164 MET 164 165 165 MET MET A . n 
A 1 165 GLU 165 166 166 GLU GLU A . n 
A 1 166 LEU 166 167 167 LEU LEU A . n 
A 1 167 PRO 167 168 168 PRO PRO A . n 
A 1 168 THR 168 169 169 THR THR A . n 
A 1 169 GLY 169 170 170 GLY GLY A . n 
A 1 170 VAL 170 171 171 VAL VAL A . n 
A 1 171 HIS 171 172 172 HIS HIS A . n 
A 1 172 ALA 172 173 173 ALA ALA A . n 
A 1 173 GLY 173 174 174 GLY GLY A . n 
A 1 174 THR 174 175 175 THR THR A . n 
A 1 175 ASP 175 176 176 ASP ASP A . n 
A 1 176 LEU 176 177 177 LEU LEU A . n 
A 1 177 GLU 177 178 178 GLU GLU A . n 
A 1 178 GLY 178 179 179 GLY GLY A . n 
A 1 179 LYS 179 180 180 LYS LYS A . n 
A 1 180 PHE 180 181 181 PHE PHE A . n 
A 1 181 TYR 181 182 182 TYR TYR A . n 
A 1 182 GLY 182 183 183 GLY GLY A . n 
A 1 183 PRO 183 184 184 PRO PRO A . n 
A 1 184 PHE 184 185 185 PHE PHE A . n 
A 1 185 VAL 185 186 186 VAL VAL A . n 
A 1 186 ASP 186 187 187 ASP ASP A . n 
A 1 187 ARG 187 188 188 ARG ARG A . n 
A 1 188 GLN 188 189 189 GLN GLN A . n 
A 1 189 THR 189 190 190 THR THR A . n 
A 1 190 ALA 190 191 191 ALA ALA A . n 
A 1 191 GLN 191 192 192 GLN GLN A . n 
A 1 192 ALA 192 193 193 ALA ALA A . n 
A 1 193 ALA 193 194 194 ALA ALA A . n 
A 1 194 GLY 194 195 195 GLY GLY A . n 
A 1 195 THR 195 196 196 THR THR A . n 
A 1 196 ASP 196 197 197 ASP ASP A . n 
A 1 197 THR 197 198 198 THR THR A . n 
A 1 198 THR 198 199 199 THR THR A . n 
A 1 199 ILE 199 200 200 ILE ILE A . n 
A 1 200 THR 200 201 201 THR THR A . n 
A 1 201 LEU 201 202 202 LEU LEU A . n 
A 1 202 ASN 202 203 203 ASN ASN A . n 
A 1 203 VAL 203 204 204 VAL VAL A . n 
A 1 204 LEU 204 205 205 LEU LEU A . n 
A 1 205 ALA 205 206 206 ALA ALA A . n 
A 1 206 TRP 206 207 207 TRP TRP A . n 
A 1 207 LEU 207 208 208 LEU LEU A . n 
A 1 208 TYR 208 209 209 TYR TYR A . n 
A 1 209 ALA 209 210 210 ALA ALA A . n 
A 1 210 ALA 210 211 211 ALA ALA A . n 
A 1 211 VAL 211 212 212 VAL VAL A . n 
A 1 212 ILE 212 213 213 ILE ILE A . n 
A 1 213 ASN 213 214 214 ASN ASN A . n 
A 1 214 GLY 214 215 215 GLY GLY A . n 
A 1 215 ASP 215 216 216 ASP ASP A . n 
A 1 216 ARG 216 217 217 ARG ARG A . n 
A 1 217 TRP 217 218 218 TRP TRP A . n 
A 1 218 PHE 218 219 219 PHE PHE A . n 
A 1 219 LEU 219 220 220 LEU LEU A . n 
A 1 220 ASN 220 221 221 ASN ASN A . n 
A 1 221 ARG 221 222 222 ARG ARG A . n 
A 1 222 PHE 222 223 223 PHE PHE A . n 
A 1 223 THR 223 224 224 THR THR A . n 
A 1 224 THR 224 225 225 THR THR A . n 
A 1 225 THR 225 226 226 THR THR A . n 
A 1 226 LEU 226 227 227 LEU LEU A . n 
A 1 227 ASN 227 228 228 ASN ASN A . n 
A 1 228 ASP 228 229 229 ASP ASP A . n 
A 1 229 PHE 229 230 230 PHE PHE A . n 
A 1 230 ASN 230 231 231 ASN ASN A . n 
A 1 231 LEU 231 232 232 LEU LEU A . n 
A 1 232 VAL 232 233 233 VAL VAL A . n 
A 1 233 ALA 233 234 234 ALA ALA A . n 
A 1 234 MET 234 235 235 MET MET A . n 
A 1 235 LYS 235 236 236 LYS LYS A . n 
A 1 236 TYR 236 237 237 TYR TYR A . n 
A 1 237 ASN 237 238 238 ASN ASN A . n 
A 1 238 TYR 238 239 239 TYR TYR A . n 
A 1 239 GLU 239 240 240 GLU GLU A . n 
A 1 240 PRO 240 241 241 PRO PRO A . n 
A 1 241 LEU 241 242 242 LEU LEU A . n 
A 1 242 THR 242 243 243 THR THR A . n 
A 1 243 GLN 243 244 244 GLN GLN A . n 
A 1 244 ASP 244 245 245 ASP ASP A . n 
A 1 245 HIS 245 246 246 HIS HIS A . n 
A 1 246 VAL 246 247 247 VAL VAL A . n 
A 1 247 ASP 247 248 248 ASP ASP A . n 
A 1 248 ILE 248 249 249 ILE ILE A . n 
A 1 249 LEU 249 250 250 LEU LEU A . n 
A 1 250 GLY 250 251 251 GLY GLY A . n 
A 1 251 PRO 251 252 252 PRO PRO A . n 
A 1 252 LEU 252 253 253 LEU LEU A . n 
A 1 253 SER 253 254 254 SER SER A . n 
A 1 254 ALA 254 255 255 ALA ALA A . n 
A 1 255 GLN 255 256 256 GLN GLN A . n 
A 1 256 THR 256 257 257 THR THR A . n 
A 1 257 GLY 257 258 258 GLY GLY A . n 
A 1 258 ILE 258 259 259 ILE ILE A . n 
A 1 259 ALA 259 260 260 ALA ALA A . n 
A 1 260 VAL 260 261 261 VAL VAL A . n 
A 1 261 LEU 261 262 262 LEU LEU A . n 
A 1 262 ASP 262 263 263 ASP ASP A . n 
A 1 263 MET 263 264 264 MET MET A . n 
A 1 264 CYS 264 265 265 CYS CYS A . n 
A 1 265 ALA 265 266 266 ALA ALA A . n 
A 1 266 ALA 266 267 267 ALA ALA A . n 
A 1 267 LEU 267 268 268 LEU LEU A . n 
A 1 268 LYS 268 269 269 LYS LYS A . n 
A 1 269 GLU 269 270 270 GLU GLU A . n 
A 1 270 LEU 270 271 271 LEU LEU A . n 
A 1 271 LEU 271 272 272 LEU LEU A . n 
A 1 272 GLN 272 273 273 GLN GLN A . n 
A 1 273 ASN 273 274 274 ASN ASN A . n 
A 1 274 GLY 274 275 275 GLY GLY A . n 
A 1 275 MET 275 276 276 MET MET A . n 
A 1 276 ASN 276 277 277 ASN ASN A . n 
A 1 277 GLY 277 278 278 GLY GLY A . n 
A 1 278 ARG 278 279 279 ARG ARG A . n 
A 1 279 THR 279 280 280 THR THR A . n 
A 1 280 ILE 280 281 281 ILE ILE A . n 
A 1 281 LEU 281 282 282 LEU LEU A . n 
A 1 282 GLY 282 283 283 GLY GLY A . n 
A 1 283 SER 283 284 284 SER SER A . n 
A 1 284 THR 284 285 285 THR THR A . n 
A 1 285 ILE 285 286 286 ILE ILE A . n 
A 1 286 LEU 286 287 287 LEU LEU A . n 
A 1 287 GLU 287 288 288 GLU GLU A . n 
A 1 288 ASP 288 289 289 ASP ASP A . n 
A 1 289 GLU 289 290 290 GLU GLU A . n 
A 1 290 PHE 290 291 291 PHE PHE A . n 
A 1 291 THR 291 292 292 THR THR A . n 
A 1 292 PRO 292 293 293 PRO PRO A . n 
A 1 293 PHE 293 294 294 PHE PHE A . n 
A 1 294 ASP 294 295 295 ASP ASP A . n 
A 1 295 VAL 295 296 296 VAL VAL A . n 
A 1 296 VAL 296 297 297 VAL VAL A . n 
A 1 297 ARG 297 298 298 ARG ARG A . n 
A 1 298 GLN 298 299 299 GLN GLN A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X77 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X77 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 X77 1  301 1  X77 LIG A . 
C 3 HOH 1  401 3  HOH HOH A . 
C 3 HOH 2  402 8  HOH HOH A . 
C 3 HOH 3  403 16 HOH HOH A . 
C 3 HOH 4  404 1  HOH HOH A . 
C 3 HOH 5  405 5  HOH HOH A . 
C 3 HOH 6  406 23 HOH HOH A . 
C 3 HOH 7  407 10 HOH HOH A . 
C 3 HOH 8  408 7  HOH HOH A . 
C 3 HOH 9  409 12 HOH HOH A . 
C 3 HOH 10 410 9  HOH HOH A . 
C 3 HOH 11 411 19 HOH HOH A . 
C 3 HOH 12 412 22 HOH HOH A . 
C 3 HOH 13 413 20 HOH HOH A . 
C 3 HOH 14 414 4  HOH HOH A . 
C 3 HOH 15 415 14 HOH HOH A . 
C 3 HOH 16 416 6  HOH HOH A . 
C 3 HOH 17 417 21 HOH HOH A . 
C 3 HOH 18 418 11 HOH HOH A . 
C 3 HOH 19 419 15 HOH HOH A . 
C 3 HOH 20 420 18 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 46  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 46  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 46  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 46  OE2 
5  1 Y 1 A ASN 51  ? CG  ? A ASN 50  CG  
6  1 Y 1 A ASN 51  ? OD1 ? A ASN 50  OD1 
7  1 Y 1 A ASN 51  ? ND2 ? A ASN 50  ND2 
8  1 Y 1 A SER 62  ? OG  ? A SER 61  OG  
9  1 Y 1 A HIS 64  ? CG  ? A HIS 63  CG  
10 1 Y 1 A HIS 64  ? ND1 ? A HIS 63  ND1 
11 1 Y 1 A HIS 64  ? CD2 ? A HIS 63  CD2 
12 1 Y 1 A HIS 64  ? CE1 ? A HIS 63  CE1 
13 1 Y 1 A HIS 64  ? NE2 ? A HIS 63  NE2 
14 1 Y 1 A LEU 67  ? CG  ? A LEU 66  CG  
15 1 Y 1 A LEU 67  ? CD1 ? A LEU 66  CD1 
16 1 Y 1 A LEU 67  ? CD2 ? A LEU 66  CD2 
17 1 Y 1 A GLN 69  ? CG  ? A GLN 68  CG  
18 1 Y 1 A GLN 69  ? CD  ? A GLN 68  CD  
19 1 Y 1 A GLN 69  ? OE1 ? A GLN 68  OE1 
20 1 Y 1 A GLN 69  ? NE2 ? A GLN 68  NE2 
21 1 Y 1 A ASN 72  ? CG  ? A ASN 71  CG  
22 1 Y 1 A ASN 72  ? OD1 ? A ASN 71  OD1 
23 1 Y 1 A ASN 72  ? ND2 ? A ASN 71  ND2 
24 1 Y 1 A VAL 73  ? CG1 ? A VAL 72  CG1 
25 1 Y 1 A VAL 73  ? CG2 ? A VAL 72  CG2 
26 1 Y 1 A GLN 74  ? CG  ? A GLN 73  CG  
27 1 Y 1 A GLN 74  ? CD  ? A GLN 73  CD  
28 1 Y 1 A GLN 74  ? OE1 ? A GLN 73  OE1 
29 1 Y 1 A GLN 74  ? NE2 ? A GLN 73  NE2 
30 1 Y 1 A ARG 76  ? CG  ? A ARG 75  CG  
31 1 Y 1 A ARG 76  ? CD  ? A ARG 75  CD  
32 1 Y 1 A ARG 76  ? NE  ? A ARG 75  NE  
33 1 Y 1 A ARG 76  ? CZ  ? A ARG 75  CZ  
34 1 Y 1 A ARG 76  ? NH1 ? A ARG 75  NH1 
35 1 Y 1 A ARG 76  ? NH2 ? A ARG 75  NH2 
36 1 Y 1 A LYS 90  ? CG  ? A LYS 89  CG  
37 1 Y 1 A LYS 90  ? CD  ? A LYS 89  CD  
38 1 Y 1 A LYS 90  ? CE  ? A LYS 89  CE  
39 1 Y 1 A LYS 90  ? NZ  ? A LYS 89  NZ  
40 1 Y 1 A LYS 100 ? CG  ? A LYS 99  CG  
41 1 Y 1 A LYS 100 ? CD  ? A LYS 99  CD  
42 1 Y 1 A LYS 100 ? CE  ? A LYS 99  CE  
43 1 Y 1 A LYS 100 ? NZ  ? A LYS 99  NZ  
44 1 Y 1 A LYS 102 ? CG  ? A LYS 101 CG  
45 1 Y 1 A LYS 102 ? CD  ? A LYS 101 CD  
46 1 Y 1 A LYS 102 ? CE  ? A LYS 101 CE  
47 1 Y 1 A LYS 102 ? NZ  ? A LYS 101 NZ  
48 1 Y 1 A ASP 153 ? CG  ? A ASP 152 CG  
49 1 Y 1 A ASP 153 ? OD1 ? A ASP 152 OD1 
50 1 Y 1 A ASP 153 ? OD2 ? A ASP 152 OD2 
51 1 Y 1 A TYR 154 ? CG  ? A TYR 153 CG  
52 1 Y 1 A TYR 154 ? CD1 ? A TYR 153 CD1 
53 1 Y 1 A TYR 154 ? CD2 ? A TYR 153 CD2 
54 1 Y 1 A TYR 154 ? CE1 ? A TYR 153 CE1 
55 1 Y 1 A TYR 154 ? CE2 ? A TYR 153 CE2 
56 1 Y 1 A TYR 154 ? CZ  ? A TYR 153 CZ  
57 1 Y 1 A TYR 154 ? OH  ? A TYR 153 OH  
58 1 Y 1 A ASP 155 ? CG  ? A ASP 154 CG  
59 1 Y 1 A ASP 155 ? OD1 ? A ASP 154 OD1 
60 1 Y 1 A ASP 155 ? OD2 ? A ASP 154 OD2 
61 1 Y 1 A ASN 228 ? CG  ? A ASN 227 CG  
62 1 Y 1 A ASN 228 ? OD1 ? A ASN 227 OD1 
63 1 Y 1 A ASN 228 ? ND2 ? A ASN 227 ND2 
64 1 Y 1 A ASP 229 ? CG  ? A ASP 228 CG  
65 1 Y 1 A ASP 229 ? OD1 ? A ASP 228 OD1 
66 1 Y 1 A ASP 229 ? OD2 ? A ASP 228 OD2 
67 1 Y 1 A VAL 233 ? CG1 ? A VAL 232 CG1 
68 1 Y 1 A VAL 233 ? CG2 ? A VAL 232 CG2 
69 1 Y 1 A LYS 236 ? CG  ? A LYS 235 CG  
70 1 Y 1 A LYS 236 ? CD  ? A LYS 235 CD  
71 1 Y 1 A LYS 236 ? CE  ? A LYS 235 CE  
72 1 Y 1 A LYS 236 ? NZ  ? A LYS 235 NZ  
73 1 Y 1 A LYS 269 ? CG  ? A LYS 268 CG  
74 1 Y 1 A LYS 269 ? CD  ? A LYS 268 CD  
75 1 Y 1 A LYS 269 ? CE  ? A LYS 268 CE  
76 1 Y 1 A LYS 269 ? NZ  ? A LYS 268 NZ  
77 1 Y 1 A GLU 270 ? CG  ? A GLU 269 CG  
78 1 Y 1 A GLU 270 ? CD  ? A GLU 269 CD  
79 1 Y 1 A GLU 270 ? OE1 ? A GLU 269 OE1 
80 1 Y 1 A GLU 270 ? OE2 ? A GLU 269 OE2 
81 1 Y 1 A ASN 274 ? CG  ? A ASN 273 CG  
82 1 Y 1 A ASN 274 ? OD1 ? A ASN 273 OD1 
83 1 Y 1 A ASN 274 ? ND2 ? A ASN 273 ND2 
84 1 Y 1 A ASN 277 ? CG  ? A ASN 276 CG  
85 1 Y 1 A ASN 277 ? OD1 ? A ASN 276 OD1 
86 1 Y 1 A ASN 277 ? ND2 ? A ASN 276 ND2 
87 1 Y 1 A ARG 279 ? CG  ? A ARG 278 CG  
88 1 Y 1 A ARG 279 ? CD  ? A ARG 278 CD  
89 1 Y 1 A ARG 279 ? NE  ? A ARG 278 NE  
90 1 Y 1 A ARG 279 ? CZ  ? A ARG 278 CZ  
91 1 Y 1 A ARG 279 ? NH1 ? A ARG 278 NH1 
92 1 Y 1 A ARG 279 ? NH2 ? A ARG 278 NH2 
93 1 Y 1 A ARG 298 ? CG  ? A ARG 297 CG  
94 1 Y 1 A ARG 298 ? CD  ? A ARG 297 CD  
95 1 Y 1 A ARG 298 ? NE  ? A ARG 297 NE  
96 1 Y 1 A ARG 298 ? CZ  ? A ARG 297 CZ  
97 1 Y 1 A ARG 298 ? NH1 ? A ARG 297 NH1 
98 1 Y 1 A ARG 298 ? NH2 ? A ARG 297 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.549 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YKK 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     106.440 
_cell.length_a_esd                 ? 
_cell.length_b                     84.872 
_cell.length_b_esd                 ? 
_cell.length_c                     54.310 
_cell.length_c_esd                 ? 
_cell.volume                       472668.269 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YKK 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YKK 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.57 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.58 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Hepes pH7.5, 10% PEG8000, 8% Ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-04-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          47.4766657559 
_reflns.entry_id                                       8YKK 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               37.82 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20609 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.195 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.30 
_reflns_shell.d_res_low                                     2.43 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3022 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.060 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               54.5502967749 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YKK 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             37.82 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20306 
_refine.ls_number_reflns_R_free                  952 
_refine.ls_number_reflns_R_work                  19354 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.2865440465 
_refine.ls_percent_reflns_R_free                 4.688269477 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.214479341917 
_refine.ls_R_factor_R_free                       0.248031256075 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.212769316281 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33692917552 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 32.1543952963 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.352015334284 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        37.82 
_refine_hist.number_atoms_solvent             20 
_refine_hist.number_atoms_total               2270 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2216 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00731995736321 ? 2303 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.914380587806   ? 3144 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0496201287454  ? 362  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00646234392636 ? 405  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.37093829421    ? 1330 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.3037 2.4251 . . 126 2766 98.4008166043 . . . . 0.308352483236 . . . . . . . . . . . 0.375051035198 
'X-RAY DIFFRACTION' 2.4251 2.577  . . 150 2714 97.4149659864 . . . . 0.268354118755 . . . . . . . . . . . 0.310413859944 
'X-RAY DIFFRACTION' 2.577  2.776  . . 121 2698 96.5410958904 . . . . 0.252703021667 . . . . . . . . . . . 0.304581389448 
'X-RAY DIFFRACTION' 2.776  3.0552 . . 130 2737 97.4838490309 . . . . 0.253731475998 . . . . . . . . . . . 0.289760952453 
'X-RAY DIFFRACTION' 3.0552 3.497  . . 128 2803 99.3559322034 . . . . 0.245060286273 . . . . . . . . . . . 0.293376965758 
'X-RAY DIFFRACTION' 3.497  4.4048 . . 131 2813 99.4594594595 . . . . 0.20001222125  . . . . . . . . . . . 0.228922950851 
'X-RAY DIFFRACTION' 4.4048 37.82  . . 166 2823 99.3023255814 . . . . 0.170071447731 . . . . . . . . . . . 0.211392678783 
# 
_struct.entry_id                     8YKK 
_struct.title                        'Crystal structure of SARS main protease in complex with X77' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YKK 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS 
_struct_ref.pdbx_db_accession          P0C6X7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHS
MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY
MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP
LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
;
_struct_ref.pdbx_align_begin           3242 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YKK 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 298 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0C6X7 
_struct_ref_seq.db_align_beg                  3242 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3539 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       299 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1840  ? 
1 MORE         -8    ? 
1 'SSA (A^2)'  25080 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? GLY A 14  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 40  ? CYS A 43  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 52  ? ARG A 59  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 SER A 61  ? PHE A 65  ? SER A 62  PHE A 66  5 ? 5  
HELX_P HELX_P5  AA5 ILE A 199 ? ASN A 213 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 225 ? TYR A 236 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P7  AA7 THR A 242 ? LEU A 249 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P8  AA8 LEU A 249 ? GLY A 257 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P9  AA9 ALA A 259 ? GLY A 274 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 291 ? GLN A 298 ? THR A 292 GLN A 299 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 72  ? LEU A 74  ? VAL A 73  LEU A 75  
AA1 2 LEU A 66  ? ALA A 69  ? LEU A 67  ALA A 70  
AA1 3 MET A 16  ? CYS A 21  ? MET A 17  CYS A 22  
AA1 4 THR A 24  ? LEU A 31  ? THR A 25  LEU A 32  
AA1 5 THR A 34  ? PRO A 38  ? THR A 35  PRO A 39  
AA1 6 LEU A 85  ? VAL A 90  ? LEU A 86  VAL A 91  
AA1 7 VAL A 76  ? GLN A 82  ? VAL A 77  GLN A 83  
AA2 1 LYS A 99  ? PHE A 102 ? LYS A 100 PHE A 103 
AA2 2 CYS A 155 ? GLU A 165 ? CYS A 156 GLU A 166 
AA2 3 VAL A 147 ? ASP A 152 ? VAL A 148 ASP A 153 
AA2 4 THR A 110 ? TYR A 117 ? THR A 111 TYR A 118 
AA2 5 SER A 120 ? ALA A 128 ? SER A 121 ALA A 129 
AA3 1 LYS A 99  ? PHE A 102 ? LYS A 100 PHE A 103 
AA3 2 CYS A 155 ? GLU A 165 ? CYS A 156 GLU A 166 
AA3 3 HIS A 171 ? THR A 174 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 74  ? O LEU A 75  N VAL A 67  ? N VAL A 68  
AA1 2 3 O LEU A 66  ? O LEU A 67  N THR A 20  ? N THR A 21  
AA1 3 4 N VAL A 17  ? N VAL A 18  O GLY A 28  ? O GLY A 29  
AA1 4 5 N LEU A 29  ? N LEU A 30  O TYR A 36  ? O TYR A 37  
AA1 5 6 N CYS A 37  ? N CYS A 38  O LEU A 86  ? O LEU A 87  
AA1 6 7 O ARG A 87  ? O ARG A 88  N SER A 80  ? N SER A 81  
AA2 1 2 N LYS A 99  ? N LYS A 100 O VAL A 156 ? O VAL A 157 
AA2 2 3 O SER A 157 ? O SER A 158 N ASN A 150 ? N ASN A 151 
AA2 3 4 O PHE A 149 ? O PHE A 150 N SER A 112 ? N SER A 113 
AA2 4 5 N ALA A 115 ? N ALA A 116 O SER A 122 ? O SER A 123 
AA3 1 2 N LYS A 99  ? N LYS A 100 O VAL A 156 ? O VAL A 157 
AA3 2 3 N MET A 164 ? N MET A 165 O ALA A 172 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   8YKK 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OG1 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    THR 
_pdbx_validate_symm_contact.auth_seq_id_1     285 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OG1 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    THR 
_pdbx_validate_symm_contact.auth_seq_id_2     285 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_555 
_pdbx_validate_symm_contact.dist              2.10 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 51.73   -119.49 
2 1 ASN A 51  ? ? -144.73 59.78   
3 1 ASN A 84  ? ? 46.24   -115.05 
4 1 TYR A 154 ? ? 59.15   -117.95 
5 1 ASP A 176 ? ? -74.25  -168.20 
6 1 PRO A 184 ? ? -93.29  39.03   
7 1 ALA A 191 ? ? -104.84 76.50   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
X77 C02  C N N 391 
X77 C04  C N R 392 
X77 C05  C N N 393 
X77 C07  C N N 394 
X77 C08  C N N 395 
X77 C09  C N N 396 
X77 C10  C N N 397 
X77 C11  C N N 398 
X77 C12  C N N 399 
X77 C14  C Y N 400 
X77 C15  C Y N 401 
X77 C16  C Y N 402 
X77 C17  C Y N 403 
X77 C19  C Y N 404 
X77 C20  C Y N 405 
X77 C21  C Y N 406 
X77 C22  C Y N 407 
X77 C23  C Y N 408 
X77 C24  C N N 409 
X77 C25  C N N 410 
X77 C26  C N N 411 
X77 C27  C N N 412 
X77 C28  C Y N 413 
X77 C29  C Y N 414 
X77 C30  C Y N 415 
X77 C31  C Y N 416 
X77 C33  C Y N 417 
X77 N03  N N N 418 
X77 N06  N N N 419 
X77 N18  N Y N 420 
X77 N32  N Y N 421 
X77 N34  N Y N 422 
X77 O01  O N N 423 
X77 O13  O N N 424 
X77 H041 H N N 425 
X77 H071 H N N 426 
X77 H081 H N N 427 
X77 H082 H N N 428 
X77 H091 H N N 429 
X77 H092 H N N 430 
X77 H101 H N N 431 
X77 H102 H N N 432 
X77 H112 H N N 433 
X77 H111 H N N 434 
X77 H121 H N N 435 
X77 H122 H N N 436 
X77 H151 H N N 437 
X77 H161 H N N 438 
X77 H171 H N N 439 
X77 H191 H N N 440 
X77 H211 H N N 441 
X77 H221 H N N 442 
X77 H251 H N N 443 
X77 H252 H N N 444 
X77 H253 H N N 445 
X77 H261 H N N 446 
X77 H263 H N N 447 
X77 H262 H N N 448 
X77 H272 H N N 449 
X77 H273 H N N 450 
X77 H271 H N N 451 
X77 H281 H N N 452 
X77 H291 H N N 453 
X77 H311 H N N 454 
X77 H331 H N N 455 
X77 H061 H N N 456 
X77 H1   H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
X77 C33 N32  sing Y N 376 
X77 C33 N34  doub Y N 377 
X77 N32 C31  sing Y N 378 
X77 N34 C30  sing Y N 379 
X77 C31 C30  doub Y N 380 
X77 C30 C02  sing N N 381 
X77 C27 C24  sing N N 382 
X77 C02 O01  doub N N 383 
X77 C02 N03  sing N N 384 
X77 C26 C24  sing N N 385 
X77 C28 C29  doub Y N 386 
X77 C28 C23  sing Y N 387 
X77 C24 C23  sing N N 388 
X77 C24 C25  sing N N 389 
X77 C29 C20  sing Y N 390 
X77 C23 C22  doub Y N 391 
X77 C20 N03  sing N N 392 
X77 C20 C21  doub Y N 393 
X77 C22 C21  sing Y N 394 
X77 N03 C04  sing N N 395 
X77 C19 N18  doub Y N 396 
X77 C19 C14  sing Y N 397 
X77 C04 C14  sing N N 398 
X77 C04 C05  sing N N 399 
X77 N18 C17  sing Y N 400 
X77 C14 C15  doub Y N 401 
X77 O13 C05  doub N N 402 
X77 C17 C16  doub Y N 403 
X77 C05 N06  sing N N 404 
X77 C15 C16  sing Y N 405 
X77 N06 C07  sing N N 406 
X77 C12 C07  sing N N 407 
X77 C12 C11  sing N N 408 
X77 C07 C08  sing N N 409 
X77 C11 C10  sing N N 410 
X77 C08 C09  sing N N 411 
X77 C10 C09  sing N N 412 
X77 C04 H041 sing N N 413 
X77 C07 H071 sing N N 414 
X77 C08 H081 sing N N 415 
X77 C08 H082 sing N N 416 
X77 C09 H091 sing N N 417 
X77 C09 H092 sing N N 418 
X77 C10 H101 sing N N 419 
X77 C10 H102 sing N N 420 
X77 C11 H112 sing N N 421 
X77 C11 H111 sing N N 422 
X77 C12 H121 sing N N 423 
X77 C12 H122 sing N N 424 
X77 C15 H151 sing N N 425 
X77 C16 H161 sing N N 426 
X77 C17 H171 sing N N 427 
X77 C19 H191 sing N N 428 
X77 C21 H211 sing N N 429 
X77 C22 H221 sing N N 430 
X77 C25 H251 sing N N 431 
X77 C25 H252 sing N N 432 
X77 C25 H253 sing N N 433 
X77 C26 H261 sing N N 434 
X77 C26 H263 sing N N 435 
X77 C26 H262 sing N N 436 
X77 C27 H272 sing N N 437 
X77 C27 H273 sing N N 438 
X77 C27 H271 sing N N 439 
X77 C28 H281 sing N N 440 
X77 C29 H291 sing N N 441 
X77 C31 H311 sing N N 442 
X77 C33 H331 sing N N 443 
X77 N06 H061 sing N N 444 
X77 N32 H1   sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8J33 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YKK 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009395 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002614 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011782 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019112 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY A 1 1   ? 11.03985  -29.26622 -0.09746 1.000 82.63568 ? 2   GLY A N   1 
ATOM   2    C CA  . GLY A 1 1   ? 11.69076  -30.47647 0.37406  1.000 78.96029 ? 2   GLY A CA  1 
ATOM   3    C C   . GLY A 1 1   ? 11.04145  -31.01438 1.63362  1.000 80.14016 ? 2   GLY A C   1 
ATOM   4    O O   . GLY A 1 1   ? 11.60073  -31.88143 2.30893  1.000 81.90119 ? 2   GLY A O   1 
ATOM   5    N N   . PHE A 1 2   ? 9.85520   -30.48815 1.94242  1.000 75.61658 ? 3   PHE A N   1 
ATOM   6    C CA  . PHE A 1 2   ? 9.08326   -30.89389 3.11426  1.000 70.35932 ? 3   PHE A CA  1 
ATOM   7    C C   . PHE A 1 2   ? 7.61423   -30.82388 2.73421  1.000 67.56810 ? 3   PHE A C   1 
ATOM   8    O O   . PHE A 1 2   ? 7.16038   -29.77140 2.27641  1.000 71.59227 ? 3   PHE A O   1 
ATOM   9    C CB  . PHE A 1 2   ? 9.37929   -29.98603 4.31007  1.000 70.21152 ? 3   PHE A CB  1 
ATOM   10   C CG  . PHE A 1 2   ? 8.66179   -30.38595 5.57658  1.000 69.15043 ? 3   PHE A CG  1 
ATOM   11   C CD1 . PHE A 1 2   ? 7.38058   -29.91182 5.84651  1.000 66.60901 ? 3   PHE A CD1 1 
ATOM   12   C CD2 . PHE A 1 2   ? 9.27430   -31.22118 6.50108  1.000 64.53056 ? 3   PHE A CD2 1 
ATOM   13   C CE1 . PHE A 1 2   ? 6.71404   -30.27784 7.01647  1.000 66.58601 ? 3   PHE A CE1 1 
ATOM   14   C CE2 . PHE A 1 2   ? 8.62800   -31.59280 7.66690  1.000 65.15869 ? 3   PHE A CE2 1 
ATOM   15   C CZ  . PHE A 1 2   ? 7.34093   -31.12458 7.93056  1.000 64.72063 ? 3   PHE A CZ  1 
ATOM   16   N N   . ARG A 1 3   ? 6.87689   -31.92409 2.92291  1.000 62.17505 ? 4   ARG A N   1 
ATOM   17   C CA  . ARG A 1 3   ? 5.50988   -32.01985 2.41606  1.000 61.55681 ? 4   ARG A CA  1 
ATOM   18   C C   . ARG A 1 3   ? 4.67200   -32.99519 3.24107  1.000 57.64278 ? 4   ARG A C   1 
ATOM   19   O O   . ARG A 1 3   ? 5.17163   -33.70522 4.11752  1.000 54.23353 ? 4   ARG A O   1 
ATOM   20   C CB  . ARG A 1 3   ? 5.49912   -32.46943 0.95675  1.000 57.86409 ? 4   ARG A CB  1 
ATOM   21   C CG  . ARG A 1 3   ? 6.33965   -33.70425 0.71399  1.000 53.86627 ? 4   ARG A CG  1 
ATOM   22   C CD  . ARG A 1 3   ? 6.15101   -34.23301 -0.69442 1.000 45.86972 ? 4   ARG A CD  1 
ATOM   23   N NE  . ARG A 1 3   ? 6.66696   -33.31601 -1.70418 1.000 54.25931 ? 4   ARG A NE  1 
ATOM   24   C CZ  . ARG A 1 3   ? 6.34630   -33.37554 -2.99449 1.000 55.26070 ? 4   ARG A CZ  1 
ATOM   25   N NH1 . ARG A 1 3   ? 5.52400   -34.31434 -3.42929 1.000 56.26033 ? 4   ARG A NH1 1 
ATOM   26   N NH2 . ARG A 1 3   ? 6.85633   -32.51339 -3.85996 1.000 61.34318 ? 4   ARG A NH2 1 
ATOM   27   N N   . LYS A 1 4   ? 3.37934   -33.03690 2.92179  1.000 52.27216 ? 5   LYS A N   1 
ATOM   28   C CA  . LYS A 1 4   ? 2.48995   -34.04340 3.49010  1.000 54.67849 ? 5   LYS A CA  1 
ATOM   29   C C   . LYS A 1 4   ? 2.88444   -35.43771 2.99298  1.000 51.13438 ? 5   LYS A C   1 
ATOM   30   O O   . LYS A 1 4   ? 2.86379   -35.71420 1.79204  1.000 51.49873 ? 5   LYS A O   1 
ATOM   31   C CB  . LYS A 1 4   ? 1.04046   -33.73407 3.12601  1.000 54.19918 ? 5   LYS A CB  1 
ATOM   32   C CG  . LYS A 1 4   ? 0.52396   -32.40329 3.65467  1.000 52.98348 ? 5   LYS A CG  1 
ATOM   33   C CD  . LYS A 1 4   ? 0.41726   -32.41375 5.16404  1.000 56.31359 ? 5   LYS A CD  1 
ATOM   34   C CE  . LYS A 1 4   ? -0.09628  -31.07742 5.69497  1.000 57.98033 ? 5   LYS A CE  1 
ATOM   35   N NZ  . LYS A 1 4   ? -1.02289  -30.46375 4.70390  1.000 64.92057 ? 5   LYS A NZ  1 
ATOM   36   N N   . MET A 1 5   ? 3.22945   -36.31796 3.91553  1.000 45.76550 ? 6   MET A N   1 
ATOM   37   C CA  . MET A 1 5   ? 3.57475   -37.68994 3.59786  1.000 48.52060 ? 6   MET A CA  1 
ATOM   38   C C   . MET A 1 5   ? 2.57900   -38.62606 4.28285  1.000 47.61987 ? 6   MET A C   1 
ATOM   39   O O   . MET A 1 5   ? 2.39046   -38.55969 5.50289  1.000 42.74211 ? 6   MET A O   1 
ATOM   40   C CB  . MET A 1 5   ? 5.01181   -37.98699 4.04084  1.000 48.02666 ? 6   MET A CB  1 
ATOM   41   C CG  . MET A 1 5   ? 5.70911   -39.08979 3.26098  1.000 52.49203 ? 6   MET A CG  1 
ATOM   42   S SD  . MET A 1 5   ? 7.50217   -38.82249 3.12742  1.000 64.95370 ? 6   MET A SD  1 
ATOM   43   C CE  . MET A 1 5   ? 7.51805   -37.08738 2.70382  1.000 55.39873 ? 6   MET A CE  1 
ATOM   44   N N   . ALA A 1 6   ? 1.93754   -39.47666 3.49032  1.000 41.36281 ? 7   ALA A N   1 
ATOM   45   C CA  . ALA A 1 6   ? 1.10140   -40.55996 3.97660  1.000 41.59089 ? 7   ALA A CA  1 
ATOM   46   C C   . ALA A 1 6   ? 1.93599   -41.80616 4.24650  1.000 45.16306 ? 7   ALA A C   1 
ATOM   47   O O   . ALA A 1 6   ? 2.95387   -42.04366 3.58927  1.000 42.07802 ? 7   ALA A O   1 
ATOM   48   C CB  . ALA A 1 6   ? 0.03219   -40.90253 2.94515  1.000 36.77021 ? 7   ALA A CB  1 
ATOM   49   N N   . PHE A 1 7   ? 1.47438   -42.61639 5.19501  1.000 37.82318 ? 8   PHE A N   1 
ATOM   50   C CA  . PHE A 1 7   ? 2.07420   -43.91636 5.41817  1.000 42.19173 ? 8   PHE A CA  1 
ATOM   51   C C   . PHE A 1 7   ? 1.79350   -44.84082 4.23257  1.000 45.16904 ? 8   PHE A C   1 
ATOM   52   O O   . PHE A 1 7   ? 0.78240   -44.69068 3.54845  1.000 47.81578 ? 8   PHE A O   1 
ATOM   53   C CB  . PHE A 1 7   ? 1.54090   -44.55382 6.69676  1.000 40.87763 ? 8   PHE A CB  1 
ATOM   54   C CG  . PHE A 1 7   ? 2.06059   -43.91549 7.94911  1.000 44.87818 ? 8   PHE A CG  1 
ATOM   55   C CD1 . PHE A 1 7   ? 3.34949   -44.16455 8.38799  1.000 44.89015 ? 8   PHE A CD1 1 
ATOM   56   C CD2 . PHE A 1 7   ? 1.26262   -43.05591 8.68620  1.000 41.75730 ? 8   PHE A CD2 1 
ATOM   57   C CE1 . PHE A 1 7   ? 3.83698   -43.56741 9.54415  1.000 49.42249 ? 8   PHE A CE1 1 
ATOM   58   C CE2 . PHE A 1 7   ? 1.74336   -42.44997 9.83922  1.000 44.09005 ? 8   PHE A CE2 1 
ATOM   59   C CZ  . PHE A 1 7   ? 3.02265   -42.70924 10.27794 1.000 43.04106 ? 8   PHE A CZ  1 
ATOM   60   N N   . PRO A 1 8   ? 2.67811   -45.80230 3.96566  1.000 43.87706 ? 9   PRO A N   1 
ATOM   61   C CA  . PRO A 1 8   ? 2.39299   -46.78532 2.91212  1.000 43.85963 ? 9   PRO A CA  1 
ATOM   62   C C   . PRO A 1 8   ? 1.14782   -47.57680 3.28404  1.000 42.62490 ? 9   PRO A C   1 
ATOM   63   O O   . PRO A 1 8   ? 1.03396   -48.07761 4.39740  1.000 42.88230 ? 9   PRO A O   1 
ATOM   64   C CB  . PRO A 1 8   ? 3.64757   -47.67198 2.88975  1.000 41.44790 ? 9   PRO A CB  1 
ATOM   65   C CG  . PRO A 1 8   ? 4.70734   -46.87690 3.62385  1.000 45.81001 ? 9   PRO A CG  1 
ATOM   66   C CD  . PRO A 1 8   ? 3.96314   -46.05054 4.63419  1.000 40.31379 ? 9   PRO A CD  1 
ATOM   67   N N   . SER A 1 9   ? 0.22888   -47.70481 2.32920  1.000 40.98462 ? 10  SER A N   1 
ATOM   68   C CA  . SER A 1 9   ? -1.12521  -48.15832 2.59923  1.000 45.21953 ? 10  SER A CA  1 
ATOM   69   C C   . SER A 1 9   ? -1.32492  -49.65790 2.39931  1.000 47.78867 ? 10  SER A C   1 
ATOM   70   O O   . SER A 1 9   ? -2.45378  -50.14475 2.58520  1.000 45.72165 ? 10  SER A O   1 
ATOM   71   C CB  . SER A 1 9   ? -2.11861  -47.37761 1.72385  1.000 41.04606 ? 10  SER A CB  1 
ATOM   72   O OG  . SER A 1 9   ? -1.84502  -47.55984 0.34737  1.000 41.48406 ? 10  SER A OG  1 
ATOM   73   N N   . GLY A 1 10  ? -0.26048  -50.40049 2.07400  1.000 44.21376 ? 11  GLY A N   1 
ATOM   74   C CA  . GLY A 1 10  ? -0.40935  -51.81975 1.76168  1.000 44.92442 ? 11  GLY A CA  1 
ATOM   75   C C   . GLY A 1 10  ? -1.09844  -52.63325 2.84911  1.000 47.48352 ? 11  GLY A C   1 
ATOM   76   O O   . GLY A 1 10  ? -1.94645  -53.48298 2.55924  1.000 48.00299 ? 11  GLY A O   1 
ATOM   77   N N   . LYS A 1 11  ? -0.73841  -52.40221 4.11257  1.000 46.60740 ? 12  LYS A N   1 
ATOM   78   C CA  . LYS A 1 11  ? -1.30267  -53.21716 5.18649  1.000 50.40769 ? 12  LYS A CA  1 
ATOM   79   C C   . LYS A 1 11  ? -2.80538  -52.98825 5.36109  1.000 49.79405 ? 12  LYS A C   1 
ATOM   80   O O   . LYS A 1 11  ? -3.52262  -53.90464 5.77818  1.000 53.66281 ? 12  LYS A O   1 
ATOM   81   C CB  . LYS A 1 11  ? -0.56101  -52.95042 6.49756  1.000 46.76377 ? 12  LYS A CB  1 
ATOM   82   C CG  . LYS A 1 11  ? 0.80959   -53.55075 6.49870  1.000 46.97985 ? 12  LYS A CG  1 
ATOM   83   C CD  . LYS A 1 11  ? 1.58414   -53.31548 7.77129  1.000 49.57235 ? 12  LYS A CD  1 
ATOM   84   C CE  . LYS A 1 11  ? 2.75439   -54.29730 7.79996  1.000 52.81517 ? 12  LYS A CE  1 
ATOM   85   N NZ  . LYS A 1 11  ? 3.90829   -53.76712 7.00938  1.000 54.94335 ? 12  LYS A NZ  1 
ATOM   86   N N   . VAL A 1 12  ? -3.29744  -51.79162 5.04236  1.000 46.80063 ? 13  VAL A N   1 
ATOM   87   C CA  . VAL A 1 12  ? -4.72926  -51.50353 5.12579  1.000 47.20822 ? 13  VAL A CA  1 
ATOM   88   C C   . VAL A 1 12  ? -5.48125  -51.92302 3.85837  1.000 47.45909 ? 13  VAL A C   1 
ATOM   89   O O   . VAL A 1 12  ? -6.65434  -52.31721 3.93729  1.000 46.84024 ? 13  VAL A O   1 
ATOM   90   C CB  . VAL A 1 12  ? -4.94207  -50.00717 5.43049  1.000 45.11133 ? 13  VAL A CB  1 
ATOM   91   C CG1 . VAL A 1 12  ? -6.41492  -49.62922 5.31840  1.000 40.42090 ? 13  VAL A CG1 1 
ATOM   92   C CG2 . VAL A 1 12  ? -4.38290  -49.65063 6.81168  1.000 42.31130 ? 13  VAL A CG2 1 
ATOM   93   N N   . GLU A 1 13  ? -4.82600  -51.86538 2.68995  1.000 45.74436 ? 14  GLU A N   1 
ATOM   94   C CA  . GLU A 1 13  ? -5.47841  -52.25458 1.43944  1.000 47.11155 ? 14  GLU A CA  1 
ATOM   95   C C   . GLU A 1 13  ? -5.99851  -53.68641 1.48814  1.000 51.13603 ? 14  GLU A C   1 
ATOM   96   O O   . GLU A 1 13  ? -7.03708  -53.98503 0.89057  1.000 48.64966 ? 14  GLU A O   1 
ATOM   97   C CB  . GLU A 1 13  ? -4.51468  -52.11945 0.26625  1.000 46.73025 ? 14  GLU A CB  1 
ATOM   98   C CG  . GLU A 1 13  ? -4.34842  -50.72230 -0.31943 1.000 45.88631 ? 14  GLU A CG  1 
ATOM   99   C CD  . GLU A 1 13  ? -3.09695  -50.63542 -1.18998 1.000 48.59153 ? 14  GLU A CD  1 
ATOM   100  O OE1 . GLU A 1 13  ? -3.03310  -51.35932 -2.21317 1.000 47.26790 ? 14  GLU A OE1 1 
ATOM   101  O OE2 . GLU A 1 13  ? -2.17347  -49.87609 -0.83160 1.000 45.32337 ? 14  GLU A OE2 1 
ATOM   102  N N   . GLY A 1 14  ? -5.27712  -54.58334 2.17234  1.000 52.71213 ? 15  GLY A N   1 
ATOM   103  C CA  . GLY A 1 14  ? -5.67809  -55.97437 2.27341  1.000 49.60537 ? 15  GLY A CA  1 
ATOM   104  C C   . GLY A 1 14  ? -6.95291  -56.20200 3.06588  1.000 54.28083 ? 15  GLY A C   1 
ATOM   105  O O   . GLY A 1 14  ? -7.58214  -57.25052 2.90569  1.000 57.63790 ? 15  GLY A O   1 
ATOM   106  N N   . CYS A 1 15  ? -7.34481  -55.24617 3.91104  1.000 51.59982 ? 16  CYS A N   1 
ATOM   107  C CA  . CYS A 1 15  ? -8.52892  -55.34696 4.75441  1.000 47.64174 ? 16  CYS A CA  1 
ATOM   108  C C   . CYS A 1 15  ? -9.72942  -54.59665 4.21418  1.000 46.11546 ? 16  CYS A C   1 
ATOM   109  O O   . CYS A 1 15  ? -10.73954 -54.50867 4.91132  1.000 56.85738 ? 16  CYS A O   1 
ATOM   110  C CB  . CYS A 1 15  ? -8.24215  -54.82492 6.16130  1.000 48.27331 ? 16  CYS A CB  1 
ATOM   111  S SG  . CYS A 1 15  ? -6.65150  -55.26062 6.85732  1.000 56.04601 ? 16  CYS A SG  1 
ATOM   112  N N   . MET A 1 16  ? -9.66541  -54.04937 3.01087  1.000 48.35655 ? 17  MET A N   1 
ATOM   113  C CA  . MET A 1 16  ? -10.76859 -53.24253 2.49786  1.000 47.95751 ? 17  MET A CA  1 
ATOM   114  C C   . MET A 1 16  ? -11.73665 -54.14512 1.73432  1.000 53.62700 ? 17  MET A C   1 
ATOM   115  O O   . MET A 1 16  ? -11.33843 -54.80233 0.75990  1.000 46.99033 ? 17  MET A O   1 
ATOM   116  C CB  . MET A 1 16  ? -10.24620 -52.11338 1.60750  1.000 47.22972 ? 17  MET A CB  1 
ATOM   117  C CG  . MET A 1 16  ? -9.54696  -50.98178 2.38343  1.000 42.81801 ? 17  MET A CG  1 
ATOM   118  S SD  . MET A 1 16  ? -10.31975 -50.65978 3.99642  1.000 50.71251 ? 17  MET A SD  1 
ATOM   119  C CE  . MET A 1 16  ? -11.69671 -49.61320 3.52033  1.000 40.97957 ? 17  MET A CE  1 
ATOM   120  N N   . VAL A 1 17  ? -13.00477 -54.18486 2.18177  1.000 48.69837 ? 18  VAL A N   1 
ATOM   121  C CA  . VAL A 1 17  ? -14.04137 -54.96995 1.52192  1.000 48.13313 ? 18  VAL A CA  1 
ATOM   122  C C   . VAL A 1 17  ? -15.24000 -54.08980 1.20875  1.000 51.10409 ? 18  VAL A C   1 
ATOM   123  O O   . VAL A 1 17  ? -15.37193 -52.96692 1.69649  1.000 49.90478 ? 18  VAL A O   1 
ATOM   124  C CB  . VAL A 1 17  ? -14.50401 -56.18745 2.35096  1.000 52.68819 ? 18  VAL A CB  1 
ATOM   125  C CG1 . VAL A 1 17  ? -13.31527 -57.05627 2.76639  1.000 51.81030 ? 18  VAL A CG1 1 
ATOM   126  C CG2 . VAL A 1 17  ? -15.33750 -55.73534 3.54823  1.000 40.37764 ? 18  VAL A CG2 1 
ATOM   127  N N   . GLN A 1 18  ? -16.13168 -54.64053 0.39229  1.000 52.54833 ? 19  GLN A N   1 
ATOM   128  C CA  . GLN A 1 18  ? -17.38226 -53.99902 0.02703  1.000 50.55137 ? 19  GLN A CA  1 
ATOM   129  C C   . GLN A 1 18  ? -18.52132 -54.61262 0.84358  1.000 50.26139 ? 19  GLN A C   1 
ATOM   130  O O   . GLN A 1 18  ? -18.51431 -55.80924 1.13771  1.000 51.43320 ? 19  GLN A O   1 
ATOM   131  C CB  . GLN A 1 18  ? -17.63003 -54.16910 -1.46838 1.000 49.73985 ? 19  GLN A CB  1 
ATOM   132  C CG  . GLN A 1 18  ? -18.68643 -53.26309 -2.03730 1.000 53.61514 ? 19  GLN A CG  1 
ATOM   133  C CD  . GLN A 1 18  ? -19.05782 -53.65397 -3.45129 1.000 61.13961 ? 19  GLN A CD  1 
ATOM   134  O OE1 . GLN A 1 18  ? -19.74222 -52.90892 -4.16400 1.000 58.86287 ? 19  GLN A OE1 1 
ATOM   135  N NE2 . GLN A 1 18  ? -18.58953 -54.82958 -3.87623 1.000 60.60470 ? 19  GLN A NE2 1 
ATOM   136  N N   . VAL A 1 19  ? -19.48506 -53.78839 1.23745  1.000 51.82179 ? 20  VAL A N   1 
ATOM   137  C CA  . VAL A 1 19  ? -20.59802 -54.24019 2.07357  1.000 51.36984 ? 20  VAL A CA  1 
ATOM   138  C C   . VAL A 1 19  ? -21.86253 -53.64072 1.49348  1.000 55.73798 ? 20  VAL A C   1 
ATOM   139  O O   . VAL A 1 19  ? -22.00074 -52.41075 1.44145  1.000 56.67569 ? 20  VAL A O   1 
ATOM   140  C CB  . VAL A 1 19  ? -20.44438 -53.83758 3.55019  1.000 44.15564 ? 20  VAL A CB  1 
ATOM   141  C CG1 . VAL A 1 19  ? -21.75623 -54.03068 4.27450  1.000 53.39988 ? 20  VAL A CG1 1 
ATOM   142  C CG2 . VAL A 1 19  ? -19.36144 -54.65651 4.22851  1.000 44.57037 ? 20  VAL A CG2 1 
ATOM   143  N N   . THR A 1 20  ? -22.76859 -54.49914 1.03178  1.000 52.39953 ? 21  THR A N   1 
ATOM   144  C CA  . THR A 1 20  ? -24.00465 -54.06465 0.40340  1.000 57.87091 ? 21  THR A CA  1 
ATOM   145  C C   . THR A 1 20  ? -25.19834 -54.53665 1.22189  1.000 62.28178 ? 21  THR A C   1 
ATOM   146  O O   . THR A 1 20  ? -25.24915 -55.68379 1.68421  1.000 60.41434 ? 21  THR A O   1 
ATOM   147  C CB  . THR A 1 20  ? -24.11711 -54.58624 -1.02880 1.000 62.28889 ? 21  THR A CB  1 
ATOM   148  O OG1 . THR A 1 20  ? -22.89206 -54.33427 -1.72103 1.000 59.04250 ? 21  THR A OG1 1 
ATOM   149  C CG2 . THR A 1 20  ? -25.25439 -53.88880 -1.76172 1.000 61.47056 ? 21  THR A CG2 1 
ATOM   150  N N   . CYS A 1 21  ? -26.15056 -53.63461 1.40543  1.000 62.69353 ? 22  CYS A N   1 
ATOM   151  C CA  . CYS A 1 21  ? -27.37193 -53.91751 2.14914  1.000 57.07833 ? 22  CYS A CA  1 
ATOM   152  C C   . CYS A 1 21  ? -28.49163 -53.23382 1.37933  1.000 61.45818 ? 22  CYS A C   1 
ATOM   153  O O   . CYS A 1 21  ? -28.62082 -52.00460 1.42305  1.000 61.42299 ? 22  CYS A O   1 
ATOM   154  C CB  . CYS A 1 21  ? -27.28020 -53.41149 3.57948  1.000 58.03929 ? 22  CYS A CB  1 
ATOM   155  S SG  . CYS A 1 21  ? -28.59634 -53.96819 4.63838  1.000 70.52863 ? 22  CYS A SG  1 
ATOM   156  N N   . GLY A 1 22  ? -29.27383 -54.02876 0.65543  1.000 62.07578 ? 23  GLY A N   1 
ATOM   157  C CA  . GLY A 1 22  ? -30.34705 -53.49623 -0.15506 1.000 54.12776 ? 23  GLY A CA  1 
ATOM   158  C C   . GLY A 1 22  ? -29.81552 -52.67520 -1.30502 1.000 61.42250 ? 23  GLY A C   1 
ATOM   159  O O   . GLY A 1 22  ? -29.05013 -53.16741 -2.14303 1.000 64.96679 ? 23  GLY A O   1 
ATOM   160  N N   . THR A 1 23  ? -30.19643 -51.40532 -1.33294 1.000 64.07281 ? 24  THR A N   1 
ATOM   161  C CA  . THR A 1 23  ? -29.79217 -50.48957 -2.38597 1.000 62.46414 ? 24  THR A CA  1 
ATOM   162  C C   . THR A 1 23  ? -28.50466 -49.72905 -2.05377 1.000 64.52386 ? 24  THR A C   1 
ATOM   163  O O   . THR A 1 23  ? -27.98998 -49.00703 -2.91778 1.000 63.24272 ? 24  THR A O   1 
ATOM   164  C CB  . THR A 1 23  ? -30.95097 -49.50956 -2.66166 1.000 62.19133 ? 24  THR A CB  1 
ATOM   165  O OG1 . THR A 1 23  ? -30.59624 -48.59587 -3.70494 1.000 70.27404 ? 24  THR A OG1 1 
ATOM   166  C CG2 . THR A 1 23  ? -31.29324 -48.72601 -1.41153 1.000 58.97386 ? 24  THR A CG2 1 
ATOM   167  N N   . THR A 1 24  ? -27.96220 -49.88962 -0.84228 1.000 61.72946 ? 25  THR A N   1 
ATOM   168  C CA  . THR A 1 24  ? -26.82737 -49.10209 -0.36191 1.000 60.61040 ? 25  THR A CA  1 
ATOM   169  C C   . THR A 1 24  ? -25.53467 -49.91573 -0.39135 1.000 57.22770 ? 25  THR A C   1 
ATOM   170  O O   . THR A 1 24  ? -25.48721 -51.02776 0.14517  1.000 60.49847 ? 25  THR A O   1 
ATOM   171  C CB  . THR A 1 24  ? -27.07508 -48.60677 1.06501  1.000 57.02302 ? 25  THR A CB  1 
ATOM   172  O OG1 . THR A 1 24  ? -28.27954 -47.83772 1.11169  1.000 63.17718 ? 25  THR A OG1 1 
ATOM   173  C CG2 . THR A 1 24  ? -25.90003 -47.73627 1.54433  1.000 57.81633 ? 25  THR A CG2 1 
ATOM   174  N N   . THR A 1 25  ? -24.48122 -49.34794 -0.98787 1.000 58.58577 ? 26  THR A N   1 
ATOM   175  C CA  . THR A 1 25  ? -23.14305 -49.93422 -0.96003 1.000 55.33719 ? 26  THR A CA  1 
ATOM   176  C C   . THR A 1 25  ? -22.15330 -48.98390 -0.29248 1.000 53.73495 ? 26  THR A C   1 
ATOM   177  O O   . THR A 1 25  ? -22.20741 -47.76771 -0.49239 1.000 49.51847 ? 26  THR A O   1 
ATOM   178  C CB  . THR A 1 25  ? -22.62989 -50.27222 -2.36527 1.000 56.15659 ? 26  THR A CB  1 
ATOM   179  O OG1 . THR A 1 25  ? -23.64394 -50.95175 -3.10753 1.000 68.51412 ? 26  THR A OG1 1 
ATOM   180  C CG2 . THR A 1 25  ? -21.44745 -51.19375 -2.26399 1.000 56.64879 ? 26  THR A CG2 1 
ATOM   181  N N   . LEU A 1 26  ? -21.24045 -49.54863 0.48987  1.000 49.14504 ? 27  LEU A N   1 
ATOM   182  C CA  . LEU A 1 26  ? -20.18487 -48.77000 1.11328  1.000 47.76382 ? 27  LEU A CA  1 
ATOM   183  C C   . LEU A 1 26  ? -19.07550 -49.72375 1.52912  1.000 50.66829 ? 27  LEU A C   1 
ATOM   184  O O   . LEU A 1 26  ? -19.21999 -50.94794 1.45594  1.000 48.36006 ? 27  LEU A O   1 
ATOM   185  C CB  . LEU A 1 26  ? -20.70976 -47.95287 2.29944  1.000 49.67846 ? 27  LEU A CB  1 
ATOM   186  C CG  . LEU A 1 26  ? -21.63989 -48.61774 3.31931  1.000 45.00036 ? 27  LEU A CG  1 
ATOM   187  C CD1 . LEU A 1 26  ? -20.92491 -49.70661 4.11948  1.000 42.42384 ? 27  LEU A CD1 1 
ATOM   188  C CD2 . LEU A 1 26  ? -22.26984 -47.56141 4.23613  1.000 39.50730 ? 27  LEU A CD2 1 
ATOM   189  N N   . ASN A 1 27  ? -17.97483 -49.14502 1.99671  1.000 44.55304 ? 28  ASN A N   1 
ATOM   190  C CA  . ASN A 1 27  ? -16.77146 -49.90873 2.30475  1.000 44.49133 ? 28  ASN A CA  1 
ATOM   191  C C   . ASN A 1 27  ? -16.81237 -50.41823 3.73651  1.000 42.63004 ? 28  ASN A C   1 
ATOM   192  O O   . ASN A 1 27  ? -17.44607 -49.81806 4.60526  1.000 41.94919 ? 28  ASN A O   1 
ATOM   193  C CB  . ASN A 1 27  ? -15.51700 -49.04364 2.10048  1.000 41.75033 ? 28  ASN A CB  1 
ATOM   194  C CG  . ASN A 1 27  ? -15.53531 -48.32418 0.78670  1.000 40.40025 ? 28  ASN A CG  1 
ATOM   195  O OD1 . ASN A 1 27  ? -15.18093 -48.89977 -0.24002 1.000 43.00685 ? 28  ASN A OD1 1 
ATOM   196  N ND2 . ASN A 1 27  ? -15.99905 -47.07521 0.79193  1.000 37.79874 ? 28  ASN A ND2 1 
ATOM   197  N N   . GLY A 1 28  ? -16.10718 -51.52875 3.98044  1.000 42.09271 ? 29  GLY A N   1 
ATOM   198  C CA  . GLY A 1 28  ? -15.91017 -52.01889 5.32803  1.000 38.98131 ? 29  GLY A CA  1 
ATOM   199  C C   . GLY A 1 28  ? -14.49520 -52.52961 5.53079  1.000 43.32435 ? 29  GLY A C   1 
ATOM   200  O O   . GLY A 1 28  ? -13.71761 -52.68665 4.58335  1.000 45.68595 ? 29  GLY A O   1 
ATOM   201  N N   . LEU A 1 29  ? -14.18056 -52.80746 6.78807  1.000 42.21334 ? 30  LEU A N   1 
ATOM   202  C CA  . LEU A 1 29  ? -12.84675 -53.20012 7.21000  1.000 49.10376 ? 30  LEU A CA  1 
ATOM   203  C C   . LEU A 1 29  ? -12.90312 -54.61789 7.76614  1.000 50.28606 ? 30  LEU A C   1 
ATOM   204  O O   . LEU A 1 29  ? -13.62182 -54.87541 8.73674  1.000 46.49847 ? 30  LEU A O   1 
ATOM   205  C CB  . LEU A 1 29  ? -12.30886 -52.22667 8.26146  1.000 43.07971 ? 30  LEU A CB  1 
ATOM   206  C CG  . LEU A 1 29  ? -10.84209 -52.42899 8.62873  1.000 47.40524 ? 30  LEU A CG  1 
ATOM   207  C CD1 . LEU A 1 29  ? -9.92582  -51.94341 7.49295  1.000 40.90027 ? 30  LEU A CD1 1 
ATOM   208  C CD2 . LEU A 1 29  ? -10.54389 -51.69546 9.91527  1.000 46.66653 ? 30  LEU A CD2 1 
ATOM   209  N N   . TRP A 1 30  ? -12.11310 -55.51265 7.17559  1.000 52.41946 ? 31  TRP A N   1 
ATOM   210  C CA  . TRP A 1 30  ? -12.10808 -56.94600 7.46811  1.000 52.95675 ? 31  TRP A CA  1 
ATOM   211  C C   . TRP A 1 30  ? -10.82182 -57.28115 8.21662  1.000 53.33296 ? 31  TRP A C   1 
ATOM   212  O O   . TRP A 1 30  ? -9.75096  -57.39143 7.61134  1.000 54.24620 ? 31  TRP A O   1 
ATOM   213  C CB  . TRP A 1 30  ? -12.22475 -57.74470 6.16707  1.000 54.72562 ? 31  TRP A CB  1 
ATOM   214  C CG  . TRP A 1 30  ? -12.24188 -59.25091 6.31397  1.000 62.79227 ? 31  TRP A CG  1 
ATOM   215  C CD1 . TRP A 1 30  ? -12.68665 -59.97438 7.39164  1.000 62.81310 ? 31  TRP A CD1 1 
ATOM   216  C CD2 . TRP A 1 30  ? -11.81968 -60.21589 5.33466  1.000 61.31299 ? 31  TRP A CD2 1 
ATOM   217  N NE1 . TRP A 1 30  ? -12.55369 -61.32255 7.14577  1.000 62.69966 ? 31  TRP A NE1 1 
ATOM   218  C CE2 . TRP A 1 30  ? -12.02911 -61.49813 5.89148  1.000 65.19667 ? 31  TRP A CE2 1 
ATOM   219  C CE3 . TRP A 1 30  ? -11.29089 -60.12096 4.04284  1.000 62.08783 ? 31  TRP A CE3 1 
ATOM   220  C CZ2 . TRP A 1 30  ? -11.72008 -62.67443 5.20138  1.000 65.44878 ? 31  TRP A CZ2 1 
ATOM   221  C CZ3 . TRP A 1 30  ? -10.97775 -61.29437 3.35894  1.000 66.46083 ? 31  TRP A CZ3 1 
ATOM   222  C CH2 . TRP A 1 30  ? -11.19378 -62.55220 3.94281  1.000 66.44983 ? 31  TRP A CH2 1 
ATOM   223  N N   . LEU A 1 31  ? -10.92491 -57.42153 9.53167  1.000 53.62231 ? 32  LEU A N   1 
ATOM   224  C CA  . LEU A 1 31  ? -9.83704  -57.91083 10.36928 1.000 55.37215 ? 32  LEU A CA  1 
ATOM   225  C C   . LEU A 1 31  ? -10.26616 -59.22836 10.99978 1.000 58.21122 ? 32  LEU A C   1 
ATOM   226  O O   . LEU A 1 31  ? -11.36308 -59.31938 11.56457 1.000 63.10694 ? 32  LEU A O   1 
ATOM   227  C CB  . LEU A 1 31  ? -9.48012  -56.89486 11.44929 1.000 51.74435 ? 32  LEU A CB  1 
ATOM   228  C CG  . LEU A 1 31  ? -9.32307  -55.48009 10.88818 1.000 55.01233 ? 32  LEU A CG  1 
ATOM   229  C CD1 . LEU A 1 31  ? -9.68471  -54.42603 11.91962 1.000 46.40741 ? 32  LEU A CD1 1 
ATOM   230  C CD2 . LEU A 1 31  ? -7.89507  -55.26852 10.36657 1.000 49.22448 ? 32  LEU A CD2 1 
ATOM   231  N N   . ASP A 1 32  ? -9.40186  -60.23735 10.89899 1.000 61.38907 ? 33  ASP A N   1 
ATOM   232  C CA  . ASP A 1 32  ? -9.70517  -61.60556 11.30432 1.000 61.96615 ? 33  ASP A CA  1 
ATOM   233  C C   . ASP A 1 32  ? -11.00512 -62.06524 10.66189 1.000 63.23155 ? 33  ASP A C   1 
ATOM   234  O O   . ASP A 1 32  ? -11.11587 -62.08576 9.43053  1.000 61.94791 ? 33  ASP A O   1 
ATOM   235  C CB  . ASP A 1 32  ? -9.76245  -61.71225 12.82780 1.000 60.10127 ? 33  ASP A CB  1 
ATOM   236  C CG  . ASP A 1 32  ? -8.47795  -61.24010 13.48414 1.000 64.37830 ? 33  ASP A CG  1 
ATOM   237  O OD1 . ASP A 1 32  ? -7.39507  -61.73872 13.09909 1.000 71.82667 ? 33  ASP A OD1 1 
ATOM   238  O OD2 . ASP A 1 32  ? -8.53550  -60.35456 14.36629 1.000 66.84836 ? 33  ASP A OD2 1 
ATOM   239  N N   . ASP A 1 33  ? -12.00135 -62.41064 11.47918 1.000 63.69177 ? 34  ASP A N   1 
ATOM   240  C CA  . ASP A 1 33  ? -13.29765 -62.85813 10.98221 1.000 65.68744 ? 34  ASP A CA  1 
ATOM   241  C C   . ASP A 1 33  ? -14.40981 -61.84552 11.25780 1.000 65.84644 ? 34  ASP A C   1 
ATOM   242  O O   . ASP A 1 33  ? -15.58137 -62.22396 11.37336 1.000 62.80976 ? 34  ASP A O   1 
ATOM   243  C CB  . ASP A 1 33  ? -13.65579 -64.21463 11.58604 1.000 65.94918 ? 34  ASP A CB  1 
ATOM   244  C CG  . ASP A 1 33  ? -13.97770 -64.12292 13.06195 1.000 71.20715 ? 34  ASP A CG  1 
ATOM   245  O OD1 . ASP A 1 33  ? -13.40056 -63.24755 13.74632 1.000 69.78723 ? 34  ASP A OD1 1 
ATOM   246  O OD2 . ASP A 1 33  ? -14.80984 -64.92666 13.54053 1.000 79.33931 ? 34  ASP A OD2 1 
ATOM   247  N N   . THR A 1 34  ? -14.06433 -60.55956 11.37047 1.000 61.99654 ? 35  THR A N   1 
ATOM   248  C CA  . THR A 1 34  ? -15.04262 -59.49823 11.59135 1.000 58.22678 ? 35  THR A CA  1 
ATOM   249  C C   . THR A 1 34  ? -14.94223 -58.46175 10.48242 1.000 58.16668 ? 35  THR A C   1 
ATOM   250  O O   . THR A 1 34  ? -13.84133 -58.13904 10.02382 1.000 57.32129 ? 35  THR A O   1 
ATOM   251  C CB  . THR A 1 34  ? -14.82993 -58.80732 12.94216 1.000 58.26114 ? 35  THR A CB  1 
ATOM   252  O OG1 . THR A 1 34  ? -14.88485 -59.77133 13.99738 1.000 62.09881 ? 35  THR A OG1 1 
ATOM   253  C CG2 . THR A 1 34  ? -15.88146 -57.74103 13.18004 1.000 52.55383 ? 35  THR A CG2 1 
ATOM   254  N N   . VAL A 1 35  ? -16.08777 -57.93536 10.05793 1.000 54.49143 ? 36  VAL A N   1 
ATOM   255  C CA  . VAL A 1 35  ? -16.14703 -56.82290 9.11396  1.000 51.62879 ? 36  VAL A CA  1 
ATOM   256  C C   . VAL A 1 35  ? -16.81826 -55.65851 9.82083  1.000 50.52413 ? 36  VAL A C   1 
ATOM   257  O O   . VAL A 1 35  ? -17.97943 -55.76769 10.22953 1.000 51.53629 ? 36  VAL A O   1 
ATOM   258  C CB  . VAL A 1 35  ? -16.91773 -57.18765 7.83697  1.000 51.82089 ? 36  VAL A CB  1 
ATOM   259  C CG1 . VAL A 1 35  ? -17.12282 -55.95005 6.95365  1.000 47.11547 ? 36  VAL A CG1 1 
ATOM   260  C CG2 . VAL A 1 35  ? -16.21496 -58.29586 7.09241  1.000 49.73111 ? 36  VAL A CG2 1 
ATOM   261  N N   . TYR A 1 36  ? -16.09076 -54.55794 9.98451  1.000 45.92585 ? 37  TYR A N   1 
ATOM   262  C CA  . TYR A 1 36  ? -16.62054 -53.34379 10.59164 1.000 39.36697 ? 37  TYR A CA  1 
ATOM   263  C C   . TYR A 1 36  ? -16.99166 -52.35476 9.50185  1.000 42.24055 ? 37  TYR A C   1 
ATOM   264  O O   . TYR A 1 36  ? -16.21609 -52.13588 8.56028  1.000 45.92562 ? 37  TYR A O   1 
ATOM   265  C CB  . TYR A 1 36  ? -15.60376 -52.67934 11.51640 1.000 40.83124 ? 37  TYR A CB  1 
ATOM   266  C CG  . TYR A 1 36  ? -14.94726 -53.54281 12.55627 1.000 42.45954 ? 37  TYR A CG  1 
ATOM   267  C CD1 . TYR A 1 36  ? -13.94883 -54.46825 12.22654 1.000 46.72045 ? 37  TYR A CD1 1 
ATOM   268  C CD2 . TYR A 1 36  ? -15.29129 -53.39604 13.88947 1.000 47.91878 ? 37  TYR A CD2 1 
ATOM   269  C CE1 . TYR A 1 36  ? -13.34338 -55.24212 13.21369 1.000 45.43714 ? 37  TYR A CE1 1 
ATOM   270  C CE2 . TYR A 1 36  ? -14.70421 -54.15744 14.87052 1.000 48.48619 ? 37  TYR A CE2 1 
ATOM   271  C CZ  . TYR A 1 36  ? -13.74448 -55.07114 14.54224 1.000 49.87856 ? 37  TYR A CZ  1 
ATOM   272  O OH  . TYR A 1 36  ? -13.20358 -55.78354 15.57941 1.000 55.11603 ? 37  TYR A OH  1 
ATOM   273  N N   . CYS A 1 37  ? -18.13764 -51.70748 9.65660  1.000 37.81030 ? 38  CYS A N   1 
ATOM   274  C CA  . CYS A 1 37  ? -18.59765 -50.75975 8.65266  1.000 37.51544 ? 38  CYS A CA  1 
ATOM   275  C C   . CYS A 1 37  ? -19.59747 -49.82660 9.31080  1.000 42.08699 ? 38  CYS A C   1 
ATOM   276  O O   . CYS A 1 37  ? -20.07179 -50.11015 10.41418 1.000 45.90902 ? 38  CYS A O   1 
ATOM   277  C CB  . CYS A 1 37  ? -19.20709 -51.49266 7.44368  1.000 44.10003 ? 38  CYS A CB  1 
ATOM   278  S SG  . CYS A 1 37  ? -20.96206 -52.02977 7.62661  1.000 51.20810 ? 38  CYS A SG  1 
ATOM   279  N N   . PRO A 1 38  ? -19.89584 -48.67661 8.69405  1.000 46.27802 ? 39  PRO A N   1 
ATOM   280  C CA  . PRO A 1 38  ? -20.86329 -47.75297 9.32035  1.000 42.62351 ? 39  PRO A CA  1 
ATOM   281  C C   . PRO A 1 38  ? -22.24009 -48.39143 9.41724  1.000 43.57194 ? 39  PRO A C   1 
ATOM   282  O O   . PRO A 1 38  ? -22.72274 -49.02783 8.47838  1.000 44.49192 ? 39  PRO A O   1 
ATOM   283  C CB  . PRO A 1 38  ? -20.87828 -46.53702 8.38776  1.000 37.83220 ? 39  PRO A CB  1 
ATOM   284  C CG  . PRO A 1 38  ? -19.52570 -46.64686 7.58163  1.000 42.48388 ? 39  PRO A CG  1 
ATOM   285  C CD  . PRO A 1 38  ? -19.25624 -48.11566 7.48477  1.000 40.02566 ? 39  PRO A CD  1 
ATOM   286  N N   . ARG A 1 39  ? -22.88624 -48.20052 10.56163 1.000 46.78392 ? 40  ARG A N   1 
ATOM   287  C CA  . ARG A 1 39  ? -24.20901 -48.79856 10.72809 1.000 44.34498 ? 40  ARG A CA  1 
ATOM   288  C C   . ARG A 1 39  ? -25.25145 -48.16368 9.82147  1.000 45.82947 ? 40  ARG A C   1 
ATOM   289  O O   . ARG A 1 39  ? -26.25609 -48.81736 9.51852  1.000 49.39347 ? 40  ARG A O   1 
ATOM   290  C CB  . ARG A 1 39  ? -24.64322 -48.72095 12.18379 1.000 40.73545 ? 40  ARG A CB  1 
ATOM   291  C CG  . ARG A 1 39  ? -25.28159 -47.43087 12.57626 1.000 42.12360 ? 40  ARG A CG  1 
ATOM   292  C CD  . ARG A 1 39  ? -25.63320 -47.47356 14.02963 1.000 42.37135 ? 40  ARG A CD  1 
ATOM   293  N NE  . ARG A 1 39  ? -25.88238 -46.13680 14.51446 1.000 45.34695 ? 40  ARG A NE  1 
ATOM   294  C CZ  . ARG A 1 39  ? -26.48977 -45.86044 15.66167 1.000 47.89805 ? 40  ARG A CZ  1 
ATOM   295  N NH1 . ARG A 1 39  ? -26.90299 -46.84432 16.45624 1.000 43.70171 ? 40  ARG A NH1 1 
ATOM   296  N NH2 . ARG A 1 39  ? -26.67203 -44.59508 16.01294 1.000 43.85561 ? 40  ARG A NH2 1 
ATOM   297  N N   . HIS A 1 40  ? -25.02326 -46.93509 9.33364  1.000 44.31345 ? 41  HIS A N   1 
ATOM   298  C CA  . HIS A 1 40  ? -26.04759 -46.30797 8.49887  1.000 43.77862 ? 41  HIS A CA  1 
ATOM   299  C C   . HIS A 1 40  ? -26.20638 -46.99385 7.15280  1.000 43.71878 ? 41  HIS A C   1 
ATOM   300  O O   . HIS A 1 40  ? -27.05654 -46.56479 6.36626  1.000 41.81548 ? 41  HIS A O   1 
ATOM   301  C CB  . HIS A 1 40  ? -25.77618 -44.80473 8.30372  1.000 39.82155 ? 41  HIS A CB  1 
ATOM   302  C CG  . HIS A 1 40  ? -24.56094 -44.47959 7.47696  1.000 44.06427 ? 41  HIS A CG  1 
ATOM   303  N ND1 . HIS A 1 40  ? -24.44020 -44.81497 6.14177  1.000 41.22705 ? 41  HIS A ND1 1 
ATOM   304  C CD2 . HIS A 1 40  ? -23.42917 -43.79695 7.79406  1.000 46.37745 ? 41  HIS A CD2 1 
ATOM   305  C CE1 . HIS A 1 40  ? -23.27869 -44.37316 5.68032  1.000 46.20885 ? 41  HIS A CE1 1 
ATOM   306  N NE2 . HIS A 1 40  ? -22.64633 -43.75261 6.66263  1.000 39.37255 ? 41  HIS A NE2 1 
ATOM   307  N N   . VAL A 1 41  ? -25.40356 -48.02651 6.87363  1.000 39.84559 ? 42  VAL A N   1 
ATOM   308  C CA  . VAL A 1 41  ? -25.62367 -48.87223 5.70527  1.000 47.72397 ? 42  VAL A CA  1 
ATOM   309  C C   . VAL A 1 41  ? -27.01324 -49.51664 5.73930  1.000 51.60559 ? 42  VAL A C   1 
ATOM   310  O O   . VAL A 1 41  ? -27.56195 -49.86743 4.68921  1.000 55.93798 ? 42  VAL A O   1 
ATOM   311  C CB  . VAL A 1 41  ? -24.51842 -49.94603 5.60144  1.000 49.32865 ? 42  VAL A CB  1 
ATOM   312  C CG1 . VAL A 1 41  ? -24.67566 -51.01574 6.70821  1.000 43.37559 ? 42  VAL A CG1 1 
ATOM   313  C CG2 . VAL A 1 41  ? -24.51833 -50.58599 4.21912  1.000 50.42740 ? 42  VAL A CG2 1 
ATOM   314  N N   . ILE A 1 42  ? -27.60531 -49.68950 6.92872  1.000 49.32097 ? 43  ILE A N   1 
ATOM   315  C CA  . ILE A 1 42  ? -28.95358 -50.26806 7.00417  1.000 52.45219 ? 43  ILE A CA  1 
ATOM   316  C C   . ILE A 1 42  ? -30.04169 -49.20906 6.99882  1.000 56.33641 ? 43  ILE A C   1 
ATOM   317  O O   . ILE A 1 42  ? -31.23019 -49.55458 6.91616  1.000 61.38266 ? 43  ILE A O   1 
ATOM   318  C CB  . ILE A 1 42  ? -29.16243 -51.16570 8.24251  1.000 44.78533 ? 43  ILE A CB  1 
ATOM   319  C CG1 . ILE A 1 42  ? -29.38272 -50.32414 9.50644  1.000 48.85129 ? 43  ILE A CG1 1 
ATOM   320  C CG2 . ILE A 1 42  ? -28.01015 -52.16862 8.39936  1.000 47.90710 ? 43  ILE A CG2 1 
ATOM   321  C CD1 . ILE A 1 42  ? -29.34025 -51.13043 10.80639 1.000 48.51587 ? 43  ILE A CD1 1 
ATOM   322  N N   . CYS A 1 43  ? -29.68485 -47.93520 7.10883  1.000 56.08858 ? 44  CYS A N   1 
ATOM   323  C CA  . CYS A 1 43  ? -30.66576 -46.87984 6.93391  1.000 55.91714 ? 44  CYS A CA  1 
ATOM   324  C C   . CYS A 1 43  ? -31.23697 -46.95903 5.52233  1.000 62.88467 ? 44  CYS A C   1 
ATOM   325  O O   . CYS A 1 43  ? -30.52533 -47.28051 4.56687  1.000 65.08763 ? 44  CYS A O   1 
ATOM   326  C CB  . CYS A 1 43  ? -30.01337 -45.51978 7.18986  1.000 53.23397 ? 44  CYS A CB  1 
ATOM   327  S SG  . CYS A 1 43  ? -31.12559 -44.13958 7.49756  1.000 65.91946 ? 44  CYS A SG  1 
ATOM   328  N N   . THR A 1 44  ? -32.53462 -46.70240 5.39402  1.000 66.26118 ? 45  THR A N   1 
ATOM   329  C CA  . THR A 1 44  ? -33.19696 -46.73331 4.09744  1.000 68.33724 ? 45  THR A CA  1 
ATOM   330  C C   . THR A 1 44  ? -33.26590 -45.33146 3.51086  1.000 66.59957 ? 45  THR A C   1 
ATOM   331  O O   . THR A 1 44  ? -33.17819 -44.32823 4.22432  1.000 67.14972 ? 45  THR A O   1 
ATOM   332  C CB  . THR A 1 44  ? -34.61022 -47.32541 4.20382  1.000 70.94290 ? 45  THR A CB  1 
ATOM   333  O OG1 . THR A 1 44  ? -35.21700 -46.91903 5.43866  1.000 65.36476 ? 45  THR A OG1 1 
ATOM   334  C CG2 . THR A 1 44  ? -34.56064 -48.85441 4.13024  1.000 69.21646 ? 45  THR A CG2 1 
ATOM   335  N N   . ALA A 1 45  ? -33.43194 -45.27567 2.18790  1.000 66.32534 ? 46  ALA A N   1 
ATOM   336  C CA  . ALA A 1 45  ? -33.50027 -43.98587 1.50985  1.000 69.40545 ? 46  ALA A CA  1 
ATOM   337  C C   . ALA A 1 45  ? -34.67371 -43.14981 2.00536  1.000 74.67148 ? 46  ALA A C   1 
ATOM   338  O O   . ALA A 1 45  ? -34.60146 -41.91527 1.99883  1.000 76.02069 ? 46  ALA A O   1 
ATOM   339  C CB  . ALA A 1 45  ? -33.58739 -44.19116 -0.00298 1.000 70.37458 ? 46  ALA A CB  1 
ATOM   340  N N   . GLU A 1 46  ? -35.75446 -43.79762 2.45086  1.000 75.25905 ? 47  GLU A N   1 
ATOM   341  C CA  . GLU A 1 46  ? -36.90895 -43.07133 2.96252  1.000 75.69420 ? 47  GLU A CA  1 
ATOM   342  C C   . GLU A 1 46  ? -36.71839 -42.57897 4.39633  1.000 77.20111 ? 47  GLU A C   1 
ATOM   343  O O   . GLU A 1 46  ? -37.33561 -41.57908 4.77822  1.000 78.43317 ? 47  GLU A O   1 
ATOM   344  C CB  . GLU A 1 46  ? -38.15819 -43.95631 2.87669  1.000 74.50173 ? 47  GLU A CB  1 
ATOM   345  N N   . ASP A 1 47  ? -35.85398 -43.22633 5.18252  1.000 80.75922 ? 48  ASP A N   1 
ATOM   346  C CA  . ASP A 1 47  ? -35.79048 -43.04292 6.63056  1.000 79.24289 ? 48  ASP A CA  1 
ATOM   347  C C   . ASP A 1 47  ? -34.53609 -42.29759 7.09822  1.000 72.21133 ? 48  ASP A C   1 
ATOM   348  O O   . ASP A 1 47  ? -34.01953 -42.58070 8.18063  1.000 70.93535 ? 48  ASP A O   1 
ATOM   349  C CB  . ASP A 1 47  ? -35.87063 -44.40870 7.31783  1.000 80.72197 ? 48  ASP A CB  1 
ATOM   350  C CG  . ASP A 1 47  ? -36.56406 -44.35021 8.66942  1.000 81.88070 ? 48  ASP A CG  1 
ATOM   351  O OD1 . ASP A 1 47  ? -36.99826 -43.24328 9.06721  1.000 79.30341 ? 48  ASP A OD1 1 
ATOM   352  O OD2 . ASP A 1 47  ? -36.67590 -45.41402 9.32893  1.000 79.40613 ? 48  ASP A OD2 1 
ATOM   353  N N   . MET A 1 48  ? -34.04410 -41.32888 6.32010  1.000 75.87407 ? 49  MET A N   1 
ATOM   354  C CA  . MET A 1 48  ? -32.76927 -40.68736 6.65135  1.000 75.94886 ? 49  MET A CA  1 
ATOM   355  C C   . MET A 1 48  ? -32.89266 -39.64500 7.75404  1.000 70.04033 ? 49  MET A C   1 
ATOM   356  O O   . MET A 1 48  ? -31.88422 -39.30670 8.37979  1.000 66.68743 ? 49  MET A O   1 
ATOM   357  C CB  . MET A 1 48  ? -32.15048 -40.02479 5.41331  1.000 66.46384 ? 49  MET A CB  1 
ATOM   358  C CG  . MET A 1 48  ? -31.70601 -41.00435 4.34145  1.000 72.42492 ? 49  MET A CG  1 
ATOM   359  S SD  . MET A 1 48  ? -30.42386 -40.39869 3.21271  1.000 93.57577 ? 49  MET A SD  1 
ATOM   360  C CE  . MET A 1 48  ? -31.09099 -38.81583 2.69730  1.000 83.83199 ? 49  MET A CE  1 
ATOM   361  N N   . LEU A 1 49  ? -34.09596 -39.13521 8.00855  1.000 67.15142 ? 50  LEU A N   1 
ATOM   362  C CA  . LEU A 1 49  ? -34.27045 -38.06786 8.98903  1.000 68.43560 ? 50  LEU A CA  1 
ATOM   363  C C   . LEU A 1 49  ? -34.30823 -38.60257 10.41732 1.000 67.72000 ? 50  LEU A C   1 
ATOM   364  O O   . LEU A 1 49  ? -33.74465 -37.98525 11.32748 1.000 65.95966 ? 50  LEU A O   1 
ATOM   365  C CB  . LEU A 1 49  ? -35.55415 -37.29202 8.68901  1.000 70.16297 ? 50  LEU A CB  1 
ATOM   366  C CG  . LEU A 1 49  ? -35.54992 -36.14713 7.67154  1.000 73.70451 ? 50  LEU A CG  1 
ATOM   367  C CD1 . LEU A 1 49  ? -34.63899 -36.41970 6.48864  1.000 74.44643 ? 50  LEU A CD1 1 
ATOM   368  C CD2 . LEU A 1 49  ? -36.97389 -35.90599 7.18549  1.000 76.89580 ? 50  LEU A CD2 1 
ATOM   369  N N   . ASN A 1 50  ? -34.97197 -39.73111 10.63954 1.000 64.19554 ? 51  ASN A N   1 
ATOM   370  C CA  . ASN A 1 50  ? -35.15316 -40.20864 12.00391 1.000 68.05316 ? 51  ASN A CA  1 
ATOM   371  C C   . ASN A 1 50  ? -35.10418 -41.73293 12.04970 1.000 69.61891 ? 51  ASN A C   1 
ATOM   372  O O   . ASN A 1 50  ? -36.07941 -42.36949 12.47197 1.000 70.43851 ? 51  ASN A O   1 
ATOM   373  C CB  . ASN A 1 50  ? -36.48266 -39.69433 12.57844 1.000 62.67730 ? 51  ASN A CB  1 
ATOM   374  N N   . PRO A 1 51  ? -34.00302 -42.35927 11.63423 1.000 66.76549 ? 52  PRO A N   1 
ATOM   375  C CA  . PRO A 1 51  ? -33.93745 -43.82011 11.68905 1.000 62.12414 ? 52  PRO A CA  1 
ATOM   376  C C   . PRO A 1 51  ? -33.72765 -44.28089 13.11619 1.000 59.54570 ? 52  PRO A C   1 
ATOM   377  O O   . PRO A 1 51  ? -33.09754 -43.59739 13.92504 1.000 64.52664 ? 52  PRO A O   1 
ATOM   378  C CB  . PRO A 1 51  ? -32.72054 -44.14898 10.81711 1.000 65.29950 ? 52  PRO A CB  1 
ATOM   379  C CG  . PRO A 1 51  ? -31.80916 -42.99836 11.04804 1.000 62.10267 ? 52  PRO A CG  1 
ATOM   380  C CD  . PRO A 1 51  ? -32.71147 -41.78131 11.21644 1.000 65.22023 ? 52  PRO A CD  1 
ATOM   381  N N   . ASN A 1 52  ? -34.27515 -45.44307 13.43006 1.000 56.83475 ? 53  ASN A N   1 
ATOM   382  C CA  . ASN A 1 52  ? -34.04272 -46.08394 14.71526 1.000 55.42012 ? 53  ASN A CA  1 
ATOM   383  C C   . ASN A 1 52  ? -33.26896 -47.35245 14.41578 1.000 54.73192 ? 53  ASN A C   1 
ATOM   384  O O   . ASN A 1 52  ? -33.80697 -48.28721 13.81198 1.000 55.81700 ? 53  ASN A O   1 
ATOM   385  C CB  . ASN A 1 52  ? -35.34851 -46.37742 15.45178 1.000 58.95498 ? 53  ASN A CB  1 
ATOM   386  C CG  . ASN A 1 52  ? -35.11490 -46.96430 16.83128 1.000 58.65589 ? 53  ASN A CG  1 
ATOM   387  O OD1 . ASN A 1 52  ? -34.71847 -48.12920 16.97073 1.000 56.27825 ? 53  ASN A OD1 1 
ATOM   388  N ND2 . ASN A 1 52  ? -35.34472 -46.15669 17.86111 1.000 58.99832 ? 53  ASN A ND2 1 
ATOM   389  N N   . TYR A 1 53  ? -32.00208 -47.37569 14.81712 1.000 53.63775 ? 54  TYR A N   1 
ATOM   390  C CA  . TYR A 1 53  ? -31.10557 -48.39431 14.28756 1.000 52.52906 ? 54  TYR A CA  1 
ATOM   391  C C   . TYR A 1 53  ? -31.32556 -49.73074 14.97220 1.000 49.84769 ? 54  TYR A C   1 
ATOM   392  O O   . TYR A 1 53  ? -31.19182 -50.78323 14.33618 1.000 48.43954 ? 54  TYR A O   1 
ATOM   393  C CB  . TYR A 1 53  ? -29.63921 -47.93366 14.40758 1.000 49.25327 ? 54  TYR A CB  1 
ATOM   394  C CG  . TYR A 1 53  ? -29.27682 -46.96337 13.30928 1.000 46.90692 ? 54  TYR A CG  1 
ATOM   395  C CD1 . TYR A 1 53  ? -29.16236 -47.39620 11.99321 1.000 45.14198 ? 54  TYR A CD1 1 
ATOM   396  C CD2 . TYR A 1 53  ? -29.08995 -45.61183 13.57834 1.000 47.16381 ? 54  TYR A CD2 1 
ATOM   397  C CE1 . TYR A 1 53  ? -28.86048 -46.51948 10.98026 1.000 48.34205 ? 54  TYR A CE1 1 
ATOM   398  C CE2 . TYR A 1 53  ? -28.78314 -44.71810 12.56932 1.000 43.64269 ? 54  TYR A CE2 1 
ATOM   399  C CZ  . TYR A 1 53  ? -28.66556 -45.17511 11.27142 1.000 49.17962 ? 54  TYR A CZ  1 
ATOM   400  O OH  . TYR A 1 53  ? -28.36908 -44.29692 10.24801 1.000 45.77158 ? 54  TYR A OH  1 
ATOM   401  N N   . GLU A 1 54  ? -31.64515 -49.71070 16.26602 1.000 53.69284 ? 55  GLU A N   1 
ATOM   402  C CA  . GLU A 1 54  ? -32.05722 -50.94527 16.91893 1.000 56.44025 ? 55  GLU A CA  1 
ATOM   403  C C   . GLU A 1 54  ? -33.23565 -51.55322 16.17220 1.000 51.61131 ? 55  GLU A C   1 
ATOM   404  O O   . GLU A 1 54  ? -33.24357 -52.75423 15.87721 1.000 51.50198 ? 55  GLU A O   1 
ATOM   405  C CB  . GLU A 1 54  ? -32.39662 -50.68045 18.38777 1.000 59.03474 ? 55  GLU A CB  1 
ATOM   406  C CG  . GLU A 1 54  ? -32.25611 -51.90910 19.30056 1.000 66.37430 ? 55  GLU A CG  1 
ATOM   407  C CD  . GLU A 1 54  ? -32.89050 -51.71891 20.69029 1.000 73.76100 ? 55  GLU A CD  1 
ATOM   408  O OE1 . GLU A 1 54  ? -32.60389 -50.70065 21.36441 1.000 76.29519 ? 55  GLU A OE1 1 
ATOM   409  O OE2 . GLU A 1 54  ? -33.68353 -52.59444 21.10720 1.000 69.18310 ? 55  GLU A OE2 1 
ATOM   410  N N   . ASP A 1 55  ? -34.18675 -50.70801 15.77006 1.000 54.28293 ? 56  ASP A N   1 
ATOM   411  C CA  . ASP A 1 55  ? -35.37212 -51.16430 15.04868 1.000 55.11806 ? 56  ASP A CA  1 
ATOM   412  C C   . ASP A 1 55  ? -34.99676 -51.75045 13.69429 1.000 56.32561 ? 56  ASP A C   1 
ATOM   413  O O   . ASP A 1 55  ? -35.44338 -52.84808 13.33693 1.000 56.22702 ? 56  ASP A O   1 
ATOM   414  C CB  . ASP A 1 55  ? -36.35474 -49.99729 14.87081 1.000 53.86900 ? 56  ASP A CB  1 
ATOM   415  C CG  . ASP A 1 55  ? -37.81335 -50.35126 15.25744 1.000 65.40163 ? 56  ASP A CG  1 
ATOM   416  O OD1 . ASP A 1 55  ? -38.12549 -51.53186 15.55249 1.000 59.21261 ? 56  ASP A OD1 1 
ATOM   417  O OD2 . ASP A 1 55  ? -38.65295 -49.41507 15.26357 1.000 67.67824 ? 56  ASP A OD2 1 
ATOM   418  N N   . LEU A 1 56  ? -34.17691 -51.02703 12.91676 1.000 55.42784 ? 57  LEU A N   1 
ATOM   419  C CA  . LEU A 1 56  ? -33.87476 -51.47705 11.55990 1.000 47.03300 ? 57  LEU A CA  1 
ATOM   420  C C   . LEU A 1 56  ? -33.03346 -52.73951 11.55910 1.000 45.87399 ? 57  LEU A C   1 
ATOM   421  O O   . LEU A 1 56  ? -33.12451 -53.53144 10.61670 1.000 49.04530 ? 57  LEU A O   1 
ATOM   422  C CB  . LEU A 1 56  ? -33.18297 -50.37035 10.77092 1.000 53.81880 ? 57  LEU A CB  1 
ATOM   423  C CG  . LEU A 1 56  ? -34.04660 -49.15024 10.43230 1.000 54.71774 ? 57  LEU A CG  1 
ATOM   424  C CD1 . LEU A 1 56  ? -33.19124 -47.88771 10.36552 1.000 48.21130 ? 57  LEU A CD1 1 
ATOM   425  C CD2 . LEU A 1 56  ? -34.80092 -49.36482 9.12682  1.000 49.07749 ? 57  LEU A CD2 1 
ATOM   426  N N   . LEU A 1 57  ? -32.25619 -52.97786 12.61416 1.000 45.32791 ? 58  LEU A N   1 
ATOM   427  C CA  . LEU A 1 57  ? -31.37281 -54.13825 12.60338 1.000 48.72077 ? 58  LEU A CA  1 
ATOM   428  C C   . LEU A 1 57  ? -32.05832 -55.42030 13.08191 1.000 50.42167 ? 58  LEU A C   1 
ATOM   429  O O   . LEU A 1 57  ? -31.67603 -56.51032 12.63807 1.000 47.63580 ? 58  LEU A O   1 
ATOM   430  C CB  . LEU A 1 57  ? -30.12706 -53.85836 13.44663 1.000 42.29734 ? 58  LEU A CB  1 
ATOM   431  C CG  . LEU A 1 57  ? -29.10679 -54.99799 13.54817 1.000 51.56397 ? 58  LEU A CG  1 
ATOM   432  C CD1 . LEU A 1 57  ? -28.33077 -55.07122 12.25187 1.000 51.60577 ? 58  LEU A CD1 1 
ATOM   433  C CD2 . LEU A 1 57  ? -28.11360 -54.85969 14.70486 1.000 54.41507 ? 58  LEU A CD2 1 
ATOM   434  N N   . ILE A 1 58  ? -33.04913 -55.33143 13.98910 1.000 50.46109 ? 59  ILE A N   1 
ATOM   435  C CA  . ILE A 1 58  ? -33.77790 -56.53469 14.40475 1.000 48.71535 ? 59  ILE A CA  1 
ATOM   436  C C   . ILE A 1 58  ? -34.42354 -57.17829 13.18471 1.000 49.32279 ? 59  ILE A C   1 
ATOM   437  O O   . ILE A 1 58  ? -34.51505 -58.40645 13.09516 1.000 52.04868 ? 59  ILE A O   1 
ATOM   438  C CB  . ILE A 1 58  ? -34.81484 -56.20739 15.52204 1.000 56.60325 ? 59  ILE A CB  1 
ATOM   439  C CG1 . ILE A 1 58  ? -35.35116 -57.47385 16.19956 1.000 52.70593 ? 59  ILE A CG1 1 
ATOM   440  C CG2 . ILE A 1 58  ? -36.01375 -55.43712 14.98928 1.000 50.59175 ? 59  ILE A CG2 1 
ATOM   441  C CD1 . ILE A 1 58  ? -34.30308 -58.48934 16.54632 1.000 59.10573 ? 59  ILE A CD1 1 
ATOM   442  N N   . ARG A 1 59  ? -34.81638 -56.36341 12.19848 1.000 51.50395 ? 60  ARG A N   1 
ATOM   443  C CA  . ARG A 1 59  ? -35.49053 -56.80965 10.98520 1.000 50.17669 ? 60  ARG A CA  1 
ATOM   444  C C   . ARG A 1 59  ? -34.56068 -57.43890 9.95255  1.000 56.82832 ? 60  ARG A C   1 
ATOM   445  O O   . ARG A 1 59  ? -35.06349 -57.96710 8.95373  1.000 59.81549 ? 60  ARG A O   1 
ATOM   446  C CB  . ARG A 1 59  ? -36.23527 -55.63113 10.35289 1.000 50.46222 ? 60  ARG A CB  1 
ATOM   447  C CG  . ARG A 1 59  ? -37.17504 -54.90608 11.31749 1.000 53.27593 ? 60  ARG A CG  1 
ATOM   448  C CD  . ARG A 1 59  ? -37.94921 -53.79428 10.61986 1.000 51.52323 ? 60  ARG A CD  1 
ATOM   449  N NE  . ARG A 1 59  ? -38.67960 -52.93509 11.55037 1.000 56.85268 ? 60  ARG A NE  1 
ATOM   450  C CZ  . ARG A 1 59  ? -39.99980 -52.98276 11.73080 1.000 60.66129 ? 60  ARG A CZ  1 
ATOM   451  N NH1 . ARG A 1 59  ? -40.72949 -53.86330 11.05396 1.000 59.31467 ? 60  ARG A NH1 1 
ATOM   452  N NH2 . ARG A 1 59  ? -40.59312 -52.16714 12.59579 1.000 61.74225 ? 60  ARG A NH2 1 
ATOM   453  N N   . LYS A 1 60  ? -33.24019 -57.40711 10.15677 1.000 48.79356 ? 61  LYS A N   1 
ATOM   454  C CA  . LYS A 1 60  ? -32.28373 -57.95589 9.20544  1.000 50.30935 ? 61  LYS A CA  1 
ATOM   455  C C   . LYS A 1 60  ? -31.85547 -59.36475 9.60736  1.000 52.81738 ? 61  LYS A C   1 
ATOM   456  O O   . LYS A 1 60  ? -31.83370 -59.71554 10.79218 1.000 53.96430 ? 61  LYS A O   1 
ATOM   457  C CB  . LYS A 1 60  ? -31.02232 -57.06524 9.09374  1.000 48.91618 ? 61  LYS A CB  1 
ATOM   458  C CG  . LYS A 1 60  ? -31.27192 -55.59743 8.77908  1.000 43.40886 ? 61  LYS A CG  1 
ATOM   459  C CD  . LYS A 1 60  ? -31.42092 -55.35999 7.29487  1.000 48.33959 ? 61  LYS A CD  1 
ATOM   460  C CE  . LYS A 1 60  ? -31.90888 -53.95114 6.99734  1.000 45.65279 ? 61  LYS A CE  1 
ATOM   461  N NZ  . LYS A 1 60  ? -33.18979 -53.68994 7.73473  1.000 67.10313 ? 61  LYS A NZ  1 
ATOM   462  N N   . SER A 1 61  ? -31.47213 -60.15301 8.60055  1.000 53.85081 ? 62  SER A N   1 
ATOM   463  C CA  . SER A 1 61  ? -30.82926 -61.45001 8.75984  1.000 54.78246 ? 62  SER A CA  1 
ATOM   464  C C   . SER A 1 61  ? -29.43728 -61.41141 8.13332  1.000 59.85929 ? 62  SER A C   1 
ATOM   465  O O   . SER A 1 61  ? -29.08894 -60.48736 7.39345  1.000 57.05841 ? 62  SER A O   1 
ATOM   466  C CB  . SER A 1 61  ? -31.66563 -62.56714 8.12021  1.000 61.09390 ? 62  SER A CB  1 
ATOM   467  N N   . ASN A 1 62  ? -28.63822 -62.43895 8.43572  1.000 58.45896 ? 63  ASN A N   1 
ATOM   468  C CA  . ASN A 1 62  ? -27.29254 -62.52869 7.87679  1.000 56.58858 ? 63  ASN A CA  1 
ATOM   469  C C   . ASN A 1 62  ? -27.30097 -62.35090 6.36558  1.000 62.02167 ? 63  ASN A C   1 
ATOM   470  O O   . ASN A 1 62  ? -26.42842 -61.67203 5.80454  1.000 65.40302 ? 63  ASN A O   1 
ATOM   471  C CB  . ASN A 1 62  ? -26.65330 -63.86462 8.24989  1.000 55.94391 ? 63  ASN A CB  1 
ATOM   472  C CG  . ASN A 1 62  ? -26.43802 -64.00377 9.74745  1.000 63.95472 ? 63  ASN A CG  1 
ATOM   473  O OD1 . ASN A 1 62  ? -26.57632 -63.03446 10.49289 1.000 65.02583 ? 63  ASN A OD1 1 
ATOM   474  N ND2 . ASN A 1 62  ? -26.09883 -65.20976 10.19539 1.000 64.00356 ? 63  ASN A ND2 1 
ATOM   475  N N   . HIS A 1 63  ? -28.29985 -62.91876 5.69540  1.000 56.49976 ? 64  HIS A N   1 
ATOM   476  C CA  . HIS A 1 63  ? -28.41912 -62.90077 4.24219  1.000 55.76872 ? 64  HIS A CA  1 
ATOM   477  C C   . HIS A 1 63  ? -28.83478 -61.54044 3.68092  1.000 56.43895 ? 64  HIS A C   1 
ATOM   478  O O   . HIS A 1 63  ? -28.97435 -61.41340 2.45931  1.000 52.72446 ? 64  HIS A O   1 
ATOM   479  C CB  . HIS A 1 63  ? -29.42982 -63.97102 3.79700  1.000 59.79213 ? 64  HIS A CB  1 
ATOM   480  N N   . SER A 1 64  ? -29.07025 -60.52534 4.50373  1.000 54.37281 ? 65  SER A N   1 
ATOM   481  C CA  . SER A 1 64  ? -29.32221 -59.20289 3.94546  1.000 57.90050 ? 65  SER A CA  1 
ATOM   482  C C   . SER A 1 64  ? -28.04788 -58.37775 3.77466  1.000 58.07844 ? 65  SER A C   1 
ATOM   483  O O   . SER A 1 64  ? -28.12376 -57.25189 3.27172  1.000 58.58373 ? 65  SER A O   1 
ATOM   484  C CB  . SER A 1 64  ? -30.33776 -58.44243 4.80173  1.000 56.25166 ? 65  SER A CB  1 
ATOM   485  O OG  . SER A 1 64  ? -30.19968 -58.77035 6.17351  1.000 59.40977 ? 65  SER A OG  1 
ATOM   486  N N   . PHE A 1 65  ? -26.88617 -58.91786 4.14402  1.000 57.02163 ? 66  PHE A N   1 
ATOM   487  C CA  . PHE A 1 65  ? -25.60253 -58.22239 4.01905  1.000 59.42807 ? 66  PHE A CA  1 
ATOM   488  C C   . PHE A 1 65  ? -24.71708 -58.96015 3.01439  1.000 61.08083 ? 66  PHE A C   1 
ATOM   489  O O   . PHE A 1 65  ? -24.20727 -60.04773 3.31085  1.000 62.40673 ? 66  PHE A O   1 
ATOM   490  C CB  . PHE A 1 65  ? -24.90026 -58.11785 5.37679  1.000 52.87302 ? 66  PHE A CB  1 
ATOM   491  C CG  . PHE A 1 65  ? -25.69820 -57.38182 6.43571  1.000 58.61865 ? 66  PHE A CG  1 
ATOM   492  C CD1 . PHE A 1 65  ? -25.88358 -56.00276 6.36334  1.000 57.00289 ? 66  PHE A CD1 1 
ATOM   493  C CD2 . PHE A 1 65  ? -26.25911 -58.07260 7.50793  1.000 56.55123 ? 66  PHE A CD2 1 
ATOM   494  C CE1 . PHE A 1 65  ? -26.61235 -55.32153 7.34357  1.000 54.67753 ? 66  PHE A CE1 1 
ATOM   495  C CE2 . PHE A 1 65  ? -26.98469 -57.40093 8.49496  1.000 54.27582 ? 66  PHE A CE2 1 
ATOM   496  C CZ  . PHE A 1 65  ? -27.16673 -56.02525 8.40855  1.000 55.02940 ? 66  PHE A CZ  1 
ATOM   497  N N   . LEU A 1 66  ? -24.51883 -58.36913 1.83344  1.000 61.14849 ? 67  LEU A N   1 
ATOM   498  C CA  . LEU A 1 66  ? -23.57009 -58.89604 0.85329  1.000 61.40031 ? 67  LEU A CA  1 
ATOM   499  C C   . LEU A 1 66  ? -22.17562 -58.33871 1.12661  1.000 61.88262 ? 67  LEU A C   1 
ATOM   500  O O   . LEU A 1 66  ? -21.98613 -57.12081 1.18628  1.000 63.24024 ? 67  LEU A O   1 
ATOM   501  C CB  . LEU A 1 66  ? -24.00582 -58.54675 -0.57187 1.000 64.21089 ? 67  LEU A CB  1 
ATOM   502  N N   . VAL A 1 67  ? -21.20268 -59.22628 1.29572  1.000 62.40761 ? 68  VAL A N   1 
ATOM   503  C CA  . VAL A 1 67  ? -19.82888 -58.83070 1.56133  1.000 58.55922 ? 68  VAL A CA  1 
ATOM   504  C C   . VAL A 1 67  ? -18.94426 -59.44399 0.48908  1.000 65.40732 ? 68  VAL A C   1 
ATOM   505  O O   . VAL A 1 67  ? -18.88567 -60.67394 0.35210  1.000 64.23364 ? 68  VAL A O   1 
ATOM   506  C CB  . VAL A 1 67  ? -19.36529 -59.26096 2.96101  1.000 62.90255 ? 68  VAL A CB  1 
ATOM   507  C CG1 . VAL A 1 67  ? -17.87408 -58.94686 3.15534  1.000 59.92160 ? 68  VAL A CG1 1 
ATOM   508  C CG2 . VAL A 1 67  ? -20.20800 -58.57655 4.01442  1.000 53.90825 ? 68  VAL A CG2 1 
ATOM   509  N N   . GLN A 1 68  ? -18.25479 -58.59073 -0.26453 1.000 61.16982 ? 69  GLN A N   1 
ATOM   510  C CA  . GLN A 1 68  ? -17.40756 -59.01149 -1.36717 1.000 57.00331 ? 69  GLN A CA  1 
ATOM   511  C C   . GLN A 1 68  ? -15.99134 -58.55709 -1.06416 1.000 64.70832 ? 69  GLN A C   1 
ATOM   512  O O   . GLN A 1 68  ? -15.73940 -57.35648 -0.91407 1.000 62.50719 ? 69  GLN A O   1 
ATOM   513  C CB  . GLN A 1 68  ? -17.90494 -58.43405 -2.69408 1.000 57.22348 ? 69  GLN A CB  1 
ATOM   514  N N   . ALA A 1 69  ? -15.08495 -59.51867 -0.92657 1.000 68.44942 ? 70  ALA A N   1 
ATOM   515  C CA  . ALA A 1 69  ? -13.65230 -59.26733 -0.80213 1.000 66.06474 ? 70  ALA A CA  1 
ATOM   516  C C   . ALA A 1 69  ? -13.05435 -59.51975 -2.17989 1.000 69.13426 ? 70  ALA A C   1 
ATOM   517  O O   . ALA A 1 69  ? -12.74497 -60.65379 -2.54577 1.000 71.56167 ? 70  ALA A O   1 
ATOM   518  C CB  . ALA A 1 69  ? -13.02383 -60.15467 0.26565  1.000 61.64036 ? 70  ALA A CB  1 
ATOM   519  N N   . GLY A 1 70  ? -12.90475 -58.44729 -2.94985 1.000 74.33470 ? 71  GLY A N   1 
ATOM   520  C CA  . GLY A 1 70  ? -12.45933 -58.58961 -4.32632 1.000 71.62192 ? 71  GLY A CA  1 
ATOM   521  C C   . GLY A 1 70  ? -13.43096 -59.46403 -5.08978 1.000 78.92177 ? 71  GLY A C   1 
ATOM   522  O O   . GLY A 1 70  ? -14.64631 -59.22112 -5.11204 1.000 74.42506 ? 71  GLY A O   1 
ATOM   523  N N   . ASN A 1 71  ? -12.89495 -60.52116 -5.70189 1.000 82.70253 ? 72  ASN A N   1 
ATOM   524  C CA  . ASN A 1 71  ? -13.74307 -61.45625 -6.43445 1.000 83.60928 ? 72  ASN A CA  1 
ATOM   525  C C   . ASN A 1 71  ? -14.63460 -62.25629 -5.48874 1.000 79.31190 ? 72  ASN A C   1 
ATOM   526  O O   . ASN A 1 71  ? -15.84480 -62.37399 -5.71495 1.000 79.96789 ? 72  ASN A O   1 
ATOM   527  C CB  . ASN A 1 71  ? -12.87350 -62.38567 -7.28303 1.000 78.68396 ? 72  ASN A CB  1 
ATOM   528  N N   . VAL A 1 72  ? -14.05984 -62.78380 -4.40771 1.000 76.55294 ? 73  VAL A N   1 
ATOM   529  C CA  . VAL A 1 72  ? -14.72168 -63.78757 -3.57729 1.000 76.84010 ? 73  VAL A CA  1 
ATOM   530  C C   . VAL A 1 72  ? -15.73152 -63.12261 -2.64835 1.000 73.54399 ? 73  VAL A C   1 
ATOM   531  O O   . VAL A 1 72  ? -15.39986 -62.17210 -1.93395 1.000 76.23898 ? 73  VAL A O   1 
ATOM   532  C CB  . VAL A 1 72  ? -13.68275 -64.58920 -2.77498 1.000 75.77681 ? 73  VAL A CB  1 
ATOM   533  N N   . GLN A 1 73  ? -16.96486 -63.62995 -2.64562 1.000 73.37145 ? 74  GLN A N   1 
ATOM   534  C CA  . GLN A 1 73  ? -17.96436 -63.21775 -1.66402 1.000 71.29776 ? 74  GLN A CA  1 
ATOM   535  C C   . GLN A 1 73  ? -17.77190 -63.97026 -0.35035 1.000 69.36595 ? 74  GLN A C   1 
ATOM   536  O O   . GLN A 1 73  ? -17.48563 -65.16946 -0.33873 1.000 71.04205 ? 74  GLN A O   1 
ATOM   537  C CB  . GLN A 1 73  ? -19.37991 -63.46695 -2.19361 1.000 69.38091 ? 74  GLN A CB  1 
ATOM   538  N N   . LEU A 1 74  ? -17.92553 -63.26284 0.76125  1.000 67.52021 ? 75  LEU A N   1 
ATOM   539  C CA  . LEU A 1 74  ? -17.84954 -63.87954 2.07766  1.000 69.59277 ? 75  LEU A CA  1 
ATOM   540  C C   . LEU A 1 74  ? -19.25340 -64.11494 2.61391  1.000 72.12745 ? 75  LEU A C   1 
ATOM   541  O O   . LEU A 1 74  ? -20.16965 -63.32882 2.35169  1.000 71.78562 ? 75  LEU A O   1 
ATOM   542  C CB  . LEU A 1 74  ? -17.07240 -63.01157 3.06836  1.000 71.01745 ? 75  LEU A CB  1 
ATOM   543  C CG  . LEU A 1 74  ? -15.80411 -62.28227 2.62789  1.000 66.83169 ? 75  LEU A CG  1 
ATOM   544  C CD1 . LEU A 1 74  ? -15.30282 -61.43158 3.78134  1.000 64.85034 ? 75  LEU A CD1 1 
ATOM   545  C CD2 . LEU A 1 74  ? -14.73015 -63.26035 2.17668  1.000 66.50469 ? 75  LEU A CD2 1 
ATOM   546  N N   . ARG A 1 75  ? -19.41395 -65.19766 3.36958  1.000 74.17474 ? 76  ARG A N   1 
ATOM   547  C CA  . ARG A 1 75  ? -20.68169 -65.51439 4.01070  1.000 70.22652 ? 76  ARG A CA  1 
ATOM   548  C C   . ARG A 1 75  ? -20.67341 -64.96521 5.42714  1.000 68.78527 ? 76  ARG A C   1 
ATOM   549  O O   . ARG A 1 75  ? -19.73083 -65.21245 6.18707  1.000 69.35745 ? 76  ARG A O   1 
ATOM   550  C CB  . ARG A 1 75  ? -20.91982 -67.02580 4.03046  1.000 74.39600 ? 76  ARG A CB  1 
ATOM   551  N N   . VAL A 1 76  ? -21.71958 -64.22357 5.77915  1.000 70.01991 ? 77  VAL A N   1 
ATOM   552  C CA  . VAL A 1 76  ? -21.87480 -63.67615 7.12204  1.000 67.43918 ? 77  VAL A CA  1 
ATOM   553  C C   . VAL A 1 76  ? -22.58455 -64.69445 8.00010  1.000 66.72935 ? 77  VAL A C   1 
ATOM   554  O O   . VAL A 1 76  ? -23.62841 -65.23419 7.61703  1.000 68.35871 ? 77  VAL A O   1 
ATOM   555  C CB  . VAL A 1 76  ? -22.65162 -62.35158 7.09245  1.000 67.48660 ? 77  VAL A CB  1 
ATOM   556  C CG1 . VAL A 1 76  ? -22.42289 -61.59586 8.38656  1.000 66.31337 ? 77  VAL A CG1 1 
ATOM   557  C CG2 . VAL A 1 76  ? -22.23538 -61.50645 5.89015  1.000 68.55397 ? 77  VAL A CG2 1 
ATOM   558  N N   . ILE A 1 77  ? -22.04301 -64.92472 9.19683  1.000 69.13923 ? 78  ILE A N   1 
ATOM   559  C CA  . ILE A 1 77  ? -22.54425 -65.92377 10.13182 1.000 67.15347 ? 78  ILE A CA  1 
ATOM   560  C C   . ILE A 1 77  ? -22.99599 -65.29622 11.45606 1.000 66.71608 ? 78  ILE A C   1 
ATOM   561  O O   . ILE A 1 77  ? -23.11296 -65.98740 12.46771 1.000 65.63609 ? 78  ILE A O   1 
ATOM   562  C CB  . ILE A 1 77  ? -21.48277 -67.01226 10.37333 1.000 63.75181 ? 78  ILE A CB  1 
ATOM   563  C CG1 . ILE A 1 77  ? -20.31484 -66.43467 11.17688 1.000 63.28430 ? 78  ILE A CG1 1 
ATOM   564  C CG2 . ILE A 1 77  ? -20.99762 -67.58054 9.05125  1.000 65.77525 ? 78  ILE A CG2 1 
ATOM   565  C CD1 . ILE A 1 77  ? -19.13087 -67.37918 11.30390 1.000 67.38554 ? 78  ILE A CD1 1 
ATOM   566  N N   . GLY A 1 78  ? -23.24667 -63.99794 11.46392 1.000 66.82719 ? 79  GLY A N   1 
ATOM   567  C CA  . GLY A 1 78  ? -23.58873 -63.28434 12.67788 1.000 64.79507 ? 79  GLY A CA  1 
ATOM   568  C C   . GLY A 1 78  ? -23.47631 -61.79405 12.47220 1.000 62.60620 ? 79  GLY A C   1 
ATOM   569  O O   . GLY A 1 78  ? -22.79962 -61.30856 11.56809 1.000 59.71788 ? 79  GLY A O   1 
ATOM   570  N N   . HIS A 1 79  ? -24.17626 -61.04399 13.31987 1.000 63.24378 ? 80  HIS A N   1 
ATOM   571  C CA  . HIS A 1 79  ? -24.11000 -59.59682 13.19355 1.000 60.40643 ? 80  HIS A CA  1 
ATOM   572  C C   . HIS A 1 79  ? -24.55443 -58.94192 14.48482 1.000 58.10415 ? 80  HIS A C   1 
ATOM   573  O O   . HIS A 1 79  ? -25.38014 -59.48025 15.21987 1.000 59.55389 ? 80  HIS A O   1 
ATOM   574  C CB  . HIS A 1 79  ? -24.95680 -59.07844 12.02960 1.000 60.41628 ? 80  HIS A CB  1 
ATOM   575  C CG  . HIS A 1 79  ? -26.42832 -59.28084 12.20717 1.000 61.23014 ? 80  HIS A CG  1 
ATOM   576  N ND1 . HIS A 1 79  ? -27.08965 -60.38790 11.72169 1.000 62.51755 ? 80  HIS A ND1 1 
ATOM   577  C CD2 . HIS A 1 79  ? -27.37062 -58.50781 12.79514 1.000 60.89009 ? 80  HIS A CD2 1 
ATOM   578  C CE1 . HIS A 1 79  ? -28.37350 -60.29566 12.01346 1.000 61.91264 ? 80  HIS A CE1 1 
ATOM   579  N NE2 . HIS A 1 79  ? -28.57129 -59.16322 12.66337 1.000 65.15947 ? 80  HIS A NE2 1 
ATOM   580  N N   . SER A 1 80  ? -23.98524 -57.77222 14.74584 1.000 57.64216 ? 81  SER A N   1 
ATOM   581  C CA  . SER A 1 80  ? -24.32895 -56.98240 15.91548 1.000 54.18694 ? 81  SER A CA  1 
ATOM   582  C C   . SER A 1 80  ? -23.94856 -55.53442 15.64988 1.000 57.26810 ? 81  SER A C   1 
ATOM   583  O O   . SER A 1 80  ? -23.32202 -55.20162 14.63808 1.000 56.11228 ? 81  SER A O   1 
ATOM   584  C CB  . SER A 1 80  ? -23.62979 -57.50350 17.17144 1.000 54.72897 ? 81  SER A CB  1 
ATOM   585  O OG  . SER A 1 80  ? -22.23521 -57.38946 17.04617 1.000 57.36074 ? 81  SER A OG  1 
ATOM   586  N N   . MET A 1 81  ? -24.31863 -54.67632 16.58646 1.000 52.46309 ? 82  MET A N   1 
ATOM   587  C CA  . MET A 1 81  ? -24.03929 -53.25760 16.47964 1.000 53.21872 ? 82  MET A CA  1 
ATOM   588  C C   . MET A 1 81  ? -23.24297 -52.81426 17.69712 1.000 56.24470 ? 82  MET A C   1 
ATOM   589  O O   . MET A 1 81  ? -23.60619 -53.13971 18.83232 1.000 54.11221 ? 82  MET A O   1 
ATOM   590  C CB  . MET A 1 81  ? -25.33157 -52.45992 16.36075 1.000 50.39684 ? 82  MET A CB  1 
ATOM   591  C CG  . MET A 1 81  ? -25.15618 -50.99756 16.63814 1.000 48.07637 ? 82  MET A CG  1 
ATOM   592  S SD  . MET A 1 81  ? -26.65472 -50.09921 16.25789 1.000 67.05659 ? 82  MET A SD  1 
ATOM   593  C CE  . MET A 1 81  ? -27.06821 -50.79097 14.66153 1.000 55.02193 ? 82  MET A CE  1 
ATOM   594  N N   . GLN A 1 82  ? -22.14503 -52.09086 17.45427 1.000 53.98436 ? 83  GLN A N   1 
ATOM   595  C CA  . GLN A 1 82  ? -21.37904 -51.42634 18.50533 1.000 50.57920 ? 83  GLN A CA  1 
ATOM   596  C C   . GLN A 1 82  ? -21.43151 -49.92660 18.24388 1.000 48.64982 ? 83  GLN A C   1 
ATOM   597  O O   . GLN A 1 82  ? -20.78622 -49.44151 17.30845 1.000 48.60262 ? 83  GLN A O   1 
ATOM   598  C CB  . GLN A 1 82  ? -19.94168 -51.93323 18.53211 1.000 50.83718 ? 83  GLN A CB  1 
ATOM   599  C CG  . GLN A 1 82  ? -19.10663 -51.30284 19.62803 1.000 54.61416 ? 83  GLN A CG  1 
ATOM   600  C CD  . GLN A 1 82  ? -17.75738 -51.97239 19.78977 1.000 56.32402 ? 83  GLN A CD  1 
ATOM   601  O OE1 . GLN A 1 82  ? -17.31501 -52.73663 18.92562 1.000 56.37006 ? 83  GLN A OE1 1 
ATOM   602  N NE2 . GLN A 1 82  ? -17.09824 -51.69916 20.90869 1.000 60.03188 ? 83  GLN A NE2 1 
ATOM   603  N N   . ASN A 1 83  ? -22.19381 -49.19831 19.06749 1.000 39.61409 ? 84  ASN A N   1 
ATOM   604  C CA  . ASN A 1 83  ? -22.46451 -47.78329 18.85660 1.000 38.91112 ? 84  ASN A CA  1 
ATOM   605  C C   . ASN A 1 83  ? -22.84322 -47.53374 17.40519 1.000 46.64928 ? 84  ASN A C   1 
ATOM   606  O O   . ASN A 1 83  ? -23.85356 -48.06274 16.93036 1.000 46.75637 ? 84  ASN A O   1 
ATOM   607  C CB  . ASN A 1 83  ? -21.26529 -46.92936 19.25416 1.000 45.78587 ? 84  ASN A CB  1 
ATOM   608  C CG  . ASN A 1 83  ? -20.82106 -47.17990 20.67814 1.000 48.17376 ? 84  ASN A CG  1 
ATOM   609  O OD1 . ASN A 1 83  ? -21.44752 -46.71164 21.62502 1.000 52.66798 ? 84  ASN A OD1 1 
ATOM   610  N ND2 . ASN A 1 83  ? -19.73475 -47.93380 20.83682 1.000 51.42998 ? 84  ASN A ND2 1 
ATOM   611  N N   . CYS A 1 84  ? -22.02508 -46.78316 16.66171 1.000 43.08450 ? 85  CYS A N   1 
ATOM   612  C CA  . CYS A 1 84  ? -22.39788 -46.42137 15.29966 1.000 41.16271 ? 85  CYS A CA  1 
ATOM   613  C C   . CYS A 1 84  ? -21.79340 -47.33772 14.25088 1.000 38.23199 ? 85  CYS A C   1 
ATOM   614  O O   . CYS A 1 84  ? -21.96102 -47.09343 13.05055 1.000 37.29646 ? 85  CYS A O   1 
ATOM   615  C CB  . CYS A 1 84  ? -22.04564 -44.96627 15.03221 1.000 45.08332 ? 85  CYS A CB  1 
ATOM   616  S SG  . CYS A 1 84  ? -23.04019 -43.89510 16.07470 1.000 44.65374 ? 85  CYS A SG  1 
ATOM   617  N N   . LEU A 1 85  ? -21.14108 -48.40582 14.67358 1.000 36.73143 ? 86  LEU A N   1 
ATOM   618  C CA  . LEU A 1 85  ? -20.61107 -49.40126 13.76715 1.000 42.18924 ? 86  LEU A CA  1 
ATOM   619  C C   . LEU A 1 85  ? -21.47195 -50.65520 13.80726 1.000 48.29844 ? 86  LEU A C   1 
ATOM   620  O O   . LEU A 1 85  ? -22.13333 -50.94203 14.80732 1.000 44.82972 ? 86  LEU A O   1 
ATOM   621  C CB  . LEU A 1 85  ? -19.16026 -49.78269 14.12260 1.000 45.52113 ? 86  LEU A CB  1 
ATOM   622  C CG  . LEU A 1 85  ? -18.07298 -48.73862 13.85029 1.000 48.52240 ? 86  LEU A CG  1 
ATOM   623  C CD1 . LEU A 1 85  ? -16.68266 -49.37013 13.92190 1.000 43.50290 ? 86  LEU A CD1 1 
ATOM   624  C CD2 . LEU A 1 85  ? -18.30769 -48.02427 12.50664 1.000 45.65863 ? 86  LEU A CD2 1 
ATOM   625  N N   . LEU A 1 86  ? -21.43562 -51.39131 12.69867 1.000 51.12555 ? 87  LEU A N   1 
ATOM   626  C CA  . LEU A 1 86  ? -21.92281 -52.75425 12.59058 1.000 45.80301 ? 87  LEU A CA  1 
ATOM   627  C C   . LEU A 1 86  ? -20.74589 -53.70421 12.56194 1.000 49.83734 ? 87  LEU A C   1 
ATOM   628  O O   . LEU A 1 86  ? -19.73075 -53.43163 11.90551 1.000 50.08012 ? 87  LEU A O   1 
ATOM   629  C CB  . LEU A 1 86  ? -22.73220 -52.96203 11.31468 1.000 47.56183 ? 87  LEU A CB  1 
ATOM   630  C CG  . LEU A 1 86  ? -24.12570 -52.35567 11.25668 1.000 51.45422 ? 87  LEU A CG  1 
ATOM   631  C CD1 . LEU A 1 86  ? -24.85422 -52.90800 10.04807 1.000 54.26477 ? 87  LEU A CD1 1 
ATOM   632  C CD2 . LEU A 1 86  ? -24.89174 -52.65680 12.54017 1.000 50.64675 ? 87  LEU A CD2 1 
ATOM   633  N N   . ARG A 1 87  ? -20.90159 -54.82883 13.24926 1.000 47.76477 ? 88  ARG A N   1 
ATOM   634  C CA  . ARG A 1 87  ? -19.91187 -55.89418 13.28305 1.000 48.73408 ? 88  ARG A CA  1 
ATOM   635  C C   . ARG A 1 87  ? -20.50793 -57.13564 12.63470 1.000 55.69610 ? 88  ARG A C   1 
ATOM   636  O O   . ARG A 1 87  ? -21.51507 -57.67377 13.11643 1.000 57.96430 ? 88  ARG A O   1 
ATOM   637  C CB  . ARG A 1 87  ? -19.46467 -56.17102 14.71589 1.000 48.87127 ? 88  ARG A CB  1 
ATOM   638  C CG  . ARG A 1 87  ? -18.82242 -54.95445 15.36556 1.000 54.63523 ? 88  ARG A CG  1 
ATOM   639  C CD  . ARG A 1 87  ? -18.40140 -55.21543 16.80459 1.000 58.36813 ? 88  ARG A CD  1 
ATOM   640  N NE  . ARG A 1 87  ? -17.79058 -56.53024 16.97375 1.000 63.60655 ? 88  ARG A NE  1 
ATOM   641  C CZ  . ARG A 1 87  ? -16.72937 -56.77635 17.73871 1.000 65.20683 ? 88  ARG A CZ  1 
ATOM   642  N NH1 . ARG A 1 87  ? -16.15625 -55.78843 18.42352 1.000 61.32723 ? 88  ARG A NH1 1 
ATOM   643  N NH2 . ARG A 1 87  ? -16.25371 -58.01651 17.83177 1.000 59.54237 ? 88  ARG A NH2 1 
ATOM   644  N N   . LEU A 1 88  ? -19.89568 -57.57604 11.53717 1.000 51.40640 ? 89  LEU A N   1 
ATOM   645  C CA  . LEU A 1 88  ? -20.33666 -58.74091 10.77371 1.000 55.71970 ? 89  LEU A CA  1 
ATOM   646  C C   . LEU A 1 88  ? -19.31723 -59.85910 10.93982 1.000 54.98227 ? 89  LEU A C   1 
ATOM   647  O O   . LEU A 1 88  ? -18.21613 -59.77999 10.38915 1.000 58.29314 ? 89  LEU A O   1 
ATOM   648  C CB  . LEU A 1 88  ? -20.50444 -58.39460 9.29504  1.000 54.68844 ? 89  LEU A CB  1 
ATOM   649  C CG  . LEU A 1 88  ? -21.23270 -57.10370 8.91630  1.000 55.07212 ? 89  LEU A CG  1 
ATOM   650  C CD1 . LEU A 1 88  ? -21.17861 -56.91310 7.41124  1.000 48.43724 ? 89  LEU A CD1 1 
ATOM   651  C CD2 . LEU A 1 88  ? -22.67948 -57.15209 9.39990  1.000 50.03416 ? 89  LEU A CD2 1 
ATOM   652  N N   . LYS A 1 89  ? -19.67847 -60.90854 11.67841 1.000 60.54559 ? 90  LYS A N   1 
ATOM   653  C CA  . LYS A 1 89  ? -18.81409 -62.07936 11.74726 1.000 61.15014 ? 90  LYS A CA  1 
ATOM   654  C C   . LYS A 1 89  ? -18.96995 -62.85659 10.45032 1.000 64.50511 ? 90  LYS A C   1 
ATOM   655  O O   . LYS A 1 89  ? -20.09503 -63.14307 10.02443 1.000 60.71925 ? 90  LYS A O   1 
ATOM   656  C CB  . LYS A 1 89  ? -19.13690 -62.95549 12.95617 1.000 55.17426 ? 90  LYS A CB  1 
ATOM   657  N N   . VAL A 1 90  ? -17.84305 -63.12588 9.79099  1.000 63.22330 ? 91  VAL A N   1 
ATOM   658  C CA  . VAL A 1 90  ? -17.82726 -63.84396 8.52890  1.000 62.62043 ? 91  VAL A CA  1 
ATOM   659  C C   . VAL A 1 90  ? -17.19919 -65.21382 8.75383  1.000 67.12455 ? 91  VAL A C   1 
ATOM   660  O O   . VAL A 1 90  ? -16.65523 -65.50825 9.81745  1.000 68.55980 ? 91  VAL A O   1 
ATOM   661  C CB  . VAL A 1 90  ? -17.09450 -63.06195 7.42184  1.000 65.74619 ? 91  VAL A CB  1 
ATOM   662  C CG1 . VAL A 1 90  ? -17.89790 -61.83119 7.03989  1.000 64.81326 ? 91  VAL A CG1 1 
ATOM   663  C CG2 . VAL A 1 90  ? -15.67403 -62.67736 7.86266  1.000 63.89508 ? 91  VAL A CG2 1 
ATOM   664  N N   . ASP A 1 91  ? -17.29169 -66.06471 7.72854  1.000 70.85199 ? 92  ASP A N   1 
ATOM   665  C CA  . ASP A 1 91  ? -16.82752 -67.44213 7.87248  1.000 74.81697 ? 92  ASP A CA  1 
ATOM   666  C C   . ASP A 1 91  ? -15.30523 -67.53121 7.79158  1.000 75.46453 ? 92  ASP A C   1 
ATOM   667  O O   . ASP A 1 91  ? -14.67985 -68.27548 8.55782  1.000 76.81891 ? 92  ASP A O   1 
ATOM   668  C CB  . ASP A 1 91  ? -17.49021 -68.33458 6.81519  1.000 75.82994 ? 92  ASP A CB  1 
ATOM   669  C CG  . ASP A 1 91  ? -17.23978 -67.85943 5.37835  1.000 82.02479 ? 92  ASP A CG  1 
ATOM   670  O OD1 . ASP A 1 91  ? -16.38485 -66.96758 5.15267  1.000 81.44039 ? 92  ASP A OD1 1 
ATOM   671  O OD2 . ASP A 1 91  ? -17.90689 -68.39540 4.46184  1.000 84.90438 ? 92  ASP A OD2 1 
ATOM   672  N N   . THR A 1 92  ? -14.69265 -66.77835 6.87841  1.000 74.36710 ? 93  THR A N   1 
ATOM   673  C CA  . THR A 1 92  ? -13.24568 -66.78835 6.70533  1.000 73.91938 ? 93  THR A CA  1 
ATOM   674  C C   . THR A 1 92  ? -12.58410 -65.73387 7.58477  1.000 71.43381 ? 93  THR A C   1 
ATOM   675  O O   . THR A 1 92  ? -13.12378 -64.64006 7.78419  1.000 68.89935 ? 93  THR A O   1 
ATOM   676  C CB  . THR A 1 92  ? -12.87075 -66.53593 5.24175  1.000 76.19774 ? 93  THR A CB  1 
ATOM   677  O OG1 . THR A 1 92  ? -13.66664 -67.36884 4.38686  1.000 80.92169 ? 93  THR A OG1 1 
ATOM   678  C CG2 . THR A 1 92  ? -11.37966 -66.82227 4.99812  1.000 73.41069 ? 93  THR A CG2 1 
ATOM   679  N N   . SER A 1 93  ? -11.42009 -66.08402 8.12367  1.000 68.41300 ? 94  SER A N   1 
ATOM   680  C CA  . SER A 1 93  ? -10.52528 -65.12177 8.74259  1.000 67.48211 ? 94  SER A CA  1 
ATOM   681  C C   . SER A 1 93  ? -9.61797  -64.52765 7.66822  1.000 68.37923 ? 94  SER A C   1 
ATOM   682  O O   . SER A 1 93  ? -9.05914  -65.26244 6.84376  1.000 66.55959 ? 94  SER A O   1 
ATOM   683  C CB  . SER A 1 93  ? -9.69500  -65.78446 9.84137  1.000 69.08297 ? 94  SER A CB  1 
ATOM   684  O OG  . SER A 1 93  ? -8.95324  -64.81671 10.56287 1.000 71.53236 ? 94  SER A OG  1 
ATOM   685  N N   . ASN A 1 94  ? -9.48230  -63.20266 7.67213  1.000 66.07529 ? 95  ASN A N   1 
ATOM   686  C CA  . ASN A 1 94  ? -8.67252  -62.52340 6.66479  1.000 64.12890 ? 95  ASN A CA  1 
ATOM   687  C C   . ASN A 1 94  ? -7.21538  -62.96523 6.77462  1.000 62.03749 ? 95  ASN A C   1 
ATOM   688  O O   . ASN A 1 94  ? -6.57535  -62.71066 7.80643  1.000 61.51202 ? 95  ASN A O   1 
ATOM   689  C CB  . ASN A 1 94  ? -8.78232  -61.00794 6.82709  1.000 61.90639 ? 95  ASN A CB  1 
ATOM   690  C CG  . ASN A 1 94  ? -8.07800  -60.23725 5.71050  1.000 62.77639 ? 95  ASN A CG  1 
ATOM   691  O OD1 . ASN A 1 94  ? -7.18493  -60.75521 5.02807  1.000 65.44900 ? 95  ASN A OD1 1 
ATOM   692  N ND2 . ASN A 1 94  ? -8.46718  -58.98380 5.53565  1.000 57.79421 ? 95  ASN A ND2 1 
ATOM   693  N N   . PRO A 1 95  ? -6.65446  -63.61745 5.75178  1.000 60.46144 ? 96  PRO A N   1 
ATOM   694  C CA  . PRO A 1 95  ? -5.24464  -64.03480 5.84575  1.000 62.32561 ? 96  PRO A CA  1 
ATOM   695  C C   . PRO A 1 95  ? -4.26814  -62.86799 5.83427  1.000 62.88109 ? 96  PRO A C   1 
ATOM   696  O O   . PRO A 1 95  ? -3.17920  -62.98222 6.40747  1.000 66.46440 ? 96  PRO A O   1 
ATOM   697  C CB  . PRO A 1 95  ? -5.06838  -64.94119 4.62065  1.000 57.81842 ? 96  PRO A CB  1 
ATOM   698  C CG  . PRO A 1 95  ? -6.08775  -64.46427 3.64591  1.000 58.52162 ? 96  PRO A CG  1 
ATOM   699  C CD  . PRO A 1 95  ? -7.26171  -63.98728 4.45991  1.000 59.47769 ? 96  PRO A CD  1 
ATOM   700  N N   . LYS A 1 96  ? -4.63043  -61.73912 5.22400  1.000 63.59066 ? 97  LYS A N   1 
ATOM   701  C CA  . LYS A 1 96  ? -3.76752  -60.56561 5.17985  1.000 63.96672 ? 97  LYS A CA  1 
ATOM   702  C C   . LYS A 1 96  ? -3.98002  -59.61543 6.35480  1.000 62.43080 ? 97  LYS A C   1 
ATOM   703  O O   . LYS A 1 96  ? -3.67916  -58.42528 6.23137  1.000 68.07723 ? 97  LYS A O   1 
ATOM   704  C CB  . LYS A 1 96  ? -3.97305  -59.81149 3.86647  1.000 62.35090 ? 97  LYS A CB  1 
ATOM   705  C CG  . LYS A 1 96  ? -3.58470  -60.60486 2.63266  1.000 61.88906 ? 97  LYS A CG  1 
ATOM   706  C CD  . LYS A 1 96  ? -4.34358  -60.12035 1.40498  1.000 60.46534 ? 97  LYS A CD  1 
ATOM   707  C CE  . LYS A 1 96  ? -3.38954  -59.79186 0.26211  1.000 74.92705 ? 97  LYS A CE  1 
ATOM   708  N NZ  . LYS A 1 96  ? -3.97681  -58.80337 -0.69216 1.000 83.25754 ? 97  LYS A NZ  1 
ATOM   709  N N   . THR A 1 97  ? -4.47878  -60.09875 7.48246  1.000 64.04149 ? 98  THR A N   1 
ATOM   710  C CA  . THR A 1 97  ? -4.67204  -59.21633 8.62622  1.000 63.17828 ? 98  THR A CA  1 
ATOM   711  C C   . THR A 1 97  ? -3.31685  -58.85249 9.22207  1.000 58.88904 ? 98  THR A C   1 
ATOM   712  O O   . THR A 1 97  ? -2.49334  -59.74410 9.46142  1.000 58.59467 ? 98  THR A O   1 
ATOM   713  C CB  . THR A 1 97  ? -5.55796  -59.86573 9.69248  1.000 60.15934 ? 98  THR A CB  1 
ATOM   714  O OG1 . THR A 1 97  ? -6.85066  -60.14524 9.14286  1.000 61.25349 ? 98  THR A OG1 1 
ATOM   715  C CG2 . THR A 1 97  ? -5.72998  -58.93083 10.87959 1.000 57.43705 ? 98  THR A CG2 1 
ATOM   716  N N   . PRO A 1 98  ? -3.04532  -57.57266 9.46547  1.000 59.83601 ? 99  PRO A N   1 
ATOM   717  C CA  . PRO A 1 98  ? -1.77761  -57.17077 10.07628 1.000 54.12976 ? 99  PRO A CA  1 
ATOM   718  C C   . PRO A 1 98  ? -1.87830  -57.13128 11.59360 1.000 54.67262 ? 99  PRO A C   1 
ATOM   719  O O   . PRO A 1 98  ? -2.95938  -57.27218 12.17739 1.000 61.34623 ? 99  PRO A O   1 
ATOM   720  C CB  . PRO A 1 98  ? -1.57388  -55.76164 9.52067  1.000 55.51557 ? 99  PRO A CB  1 
ATOM   721  C CG  . PRO A 1 98  ? -2.95520  -55.22221 9.43378  1.000 55.96734 ? 99  PRO A CG  1 
ATOM   722  C CD  . PRO A 1 98  ? -3.84089  -56.40121 9.04965  1.000 59.42789 ? 99  PRO A CD  1 
ATOM   723  N N   . LYS A 1 99  ? -0.72071  -56.94893 12.22548 1.000 52.67634 ? 100 LYS A N   1 
ATOM   724  C CA  . LYS A 1 99  ? -0.69958  -56.52698 13.61945 1.000 55.42504 ? 100 LYS A CA  1 
ATOM   725  C C   . LYS A 1 99  ? -1.40379  -55.18012 13.72086 1.000 53.64165 ? 100 LYS A C   1 
ATOM   726  O O   . LYS A 1 99  ? -1.06115  -54.24536 12.99422 1.000 55.11352 ? 100 LYS A O   1 
ATOM   727  C CB  . LYS A 1 99  ? 0.73959   -56.43489 14.12626 1.000 55.49755 ? 100 LYS A CB  1 
ATOM   728  N N   . TYR A 1 100 ? -2.41642  -55.08302 14.58446 1.000 57.49121 ? 101 TYR A N   1 
ATOM   729  C CA  . TYR A 1 100 ? -3.26159  -53.89663 14.56836 1.000 52.99486 ? 101 TYR A CA  1 
ATOM   730  C C   . TYR A 1 100 ? -3.81929  -53.59595 15.95117 1.000 55.13788 ? 101 TYR A C   1 
ATOM   731  O O   . TYR A 1 100 ? -3.82841  -54.44496 16.84500 1.000 56.62214 ? 101 TYR A O   1 
ATOM   732  C CB  . TYR A 1 100 ? -4.41027  -54.04619 13.57122 1.000 50.73499 ? 101 TYR A CB  1 
ATOM   733  C CG  . TYR A 1 100 ? -5.54286  -54.90356 14.07621 1.000 56.49647 ? 101 TYR A CG  1 
ATOM   734  C CD1 . TYR A 1 100 ? -5.49927  -56.28283 13.93857 1.000 57.48278 ? 101 TYR A CD1 1 
ATOM   735  C CD2 . TYR A 1 100 ? -6.67563  -54.33361 14.67731 1.000 54.25349 ? 101 TYR A CD2 1 
ATOM   736  C CE1 . TYR A 1 100 ? -6.53582  -57.07667 14.38274 1.000 55.52034 ? 101 TYR A CE1 1 
ATOM   737  C CE2 . TYR A 1 100 ? -7.71756  -55.12374 15.12994 1.000 53.08645 ? 101 TYR A CE2 1 
ATOM   738  C CZ  . TYR A 1 100 ? -7.64535  -56.49658 14.97380 1.000 57.08228 ? 101 TYR A CZ  1 
ATOM   739  O OH  . TYR A 1 100 ? -8.66808  -57.30395 15.42272 1.000 60.89184 ? 101 TYR A OH  1 
ATOM   740  N N   . LYS A 1 101 ? -4.32454  -52.36811 16.08780 1.000 54.23117 ? 102 LYS A N   1 
ATOM   741  C CA  . LYS A 1 101 ? -4.86980  -51.82303 17.32215 1.000 48.24908 ? 102 LYS A CA  1 
ATOM   742  C C   . LYS A 1 101 ? -5.88710  -50.74666 16.95356 1.000 48.70831 ? 102 LYS A C   1 
ATOM   743  O O   . LYS A 1 101 ? -5.81322  -50.15627 15.87097 1.000 49.81526 ? 102 LYS A O   1 
ATOM   744  C CB  . LYS A 1 101 ? -3.75493  -51.23791 18.20916 1.000 48.28022 ? 102 LYS A CB  1 
ATOM   745  N N   . PHE A 1 102 ? -6.84006  -50.50259 17.85360 1.000 46.49794 ? 103 PHE A N   1 
ATOM   746  C CA  . PHE A 1 102 ? -7.83887  -49.44113 17.71718 1.000 44.80280 ? 103 PHE A CA  1 
ATOM   747  C C   . PHE A 1 102 ? -7.50784  -48.33623 18.70433 1.000 45.39436 ? 103 PHE A C   1 
ATOM   748  O O   . PHE A 1 102 ? -7.37612  -48.59646 19.90005 1.000 47.61504 ? 103 PHE A O   1 
ATOM   749  C CB  . PHE A 1 102 ? -9.25994  -49.93625 18.01654 1.000 44.99805 ? 103 PHE A CB  1 
ATOM   750  C CG  . PHE A 1 102 ? -9.81437  -50.89654 17.00290 1.000 46.63706 ? 103 PHE A CG  1 
ATOM   751  C CD1 . PHE A 1 102 ? -9.24794  -51.00746 15.74448 1.000 45.68070 ? 103 PHE A CD1 1 
ATOM   752  C CD2 . PHE A 1 102 ? -10.90175 -51.69690 17.32046 1.000 45.52321 ? 103 PHE A CD2 1 
ATOM   753  C CE1 . PHE A 1 102 ? -9.75420  -51.89342 14.81209 1.000 48.24200 ? 103 PHE A CE1 1 
ATOM   754  C CE2 . PHE A 1 102 ? -11.41301 -52.58376 16.39637 1.000 46.72164 ? 103 PHE A CE2 1 
ATOM   755  C CZ  . PHE A 1 102 ? -10.84253 -52.69128 15.14452 1.000 46.94632 ? 103 PHE A CZ  1 
ATOM   756  N N   . VAL A 1 103 ? -7.38655  -47.10706 18.22090 1.000 44.51942 ? 104 VAL A N   1 
ATOM   757  C CA  . VAL A 1 103 ? -7.01121  -45.99902 19.08414 1.000 38.04269 ? 104 VAL A CA  1 
ATOM   758  C C   . VAL A 1 103 ? -7.91919  -44.83291 18.76153 1.000 40.42628 ? 104 VAL A C   1 
ATOM   759  O O   . VAL A 1 103 ? -8.40730  -44.68791 17.63907 1.000 46.42813 ? 104 VAL A O   1 
ATOM   760  C CB  . VAL A 1 103 ? -5.51713  -45.57737 18.92604 1.000 47.87184 ? 104 VAL A CB  1 
ATOM   761  C CG1 . VAL A 1 103 ? -4.59092  -46.80310 18.87356 1.000 45.76654 ? 104 VAL A CG1 1 
ATOM   762  C CG2 . VAL A 1 103 ? -5.31578  -44.68978 17.69818 1.000 42.90783 ? 104 VAL A CG2 1 
ATOM   763  N N   . ARG A 1 104 ? -8.15984  -44.01053 19.76188 1.000 45.00809 ? 105 ARG A N   1 
ATOM   764  C CA  . ARG A 1 104 ? -8.94752  -42.80580 19.61367 1.000 44.50481 ? 105 ARG A CA  1 
ATOM   765  C C   . ARG A 1 104 ? -7.97526  -41.64013 19.64008 1.000 43.27144 ? 105 ARG A C   1 
ATOM   766  O O   . ARG A 1 104 ? -7.27566  -41.44107 20.63437 1.000 49.65503 ? 105 ARG A O   1 
ATOM   767  C CB  . ARG A 1 104 ? -9.98214  -42.68769 20.73660 1.000 39.56759 ? 105 ARG A CB  1 
ATOM   768  C CG  . ARG A 1 104 ? -10.96865 -41.54317 20.55029 1.000 39.75861 ? 105 ARG A CG  1 
ATOM   769  C CD  . ARG A 1 104 ? -12.21664 -41.63568 21.48767 1.000 35.36761 ? 105 ARG A CD  1 
ATOM   770  N NE  . ARG A 1 104 ? -13.03283 -40.44115 21.31215 1.000 35.75307 ? 105 ARG A NE  1 
ATOM   771  C CZ  . ARG A 1 104 ? -14.04747 -40.36526 20.45718 1.000 43.14940 ? 105 ARG A CZ  1 
ATOM   772  N NH1 . ARG A 1 104 ? -14.36531 -41.43363 19.72971 1.000 39.69323 ? 105 ARG A NH1 1 
ATOM   773  N NH2 . ARG A 1 104 ? -14.75105 -39.23938 20.33524 1.000 37.01681 ? 105 ARG A NH2 1 
ATOM   774  N N   . ILE A 1 105 ? -7.93416  -40.87065 18.56246 1.000 46.53348 ? 106 ILE A N   1 
ATOM   775  C CA  . ILE A 1 105 ? -6.95380  -39.79705 18.46667 1.000 49.84474 ? 106 ILE A CA  1 
ATOM   776  C C   . ILE A 1 105 ? -7.53061  -38.53217 19.06843 1.000 46.81471 ? 106 ILE A C   1 
ATOM   777  O O   . ILE A 1 105 ? -8.73657  -38.44829 19.30949 1.000 50.07440 ? 106 ILE A O   1 
ATOM   778  C CB  . ILE A 1 105 ? -6.51831  -39.53822 17.01626 1.000 47.03520 ? 106 ILE A CB  1 
ATOM   779  C CG1 . ILE A 1 105 ? -7.75336  -39.40111 16.11706 1.000 44.72603 ? 106 ILE A CG1 1 
ATOM   780  C CG2 . ILE A 1 105 ? -5.54716  -40.59916 16.57430 1.000 50.07983 ? 106 ILE A CG2 1 
ATOM   781  C CD1 . ILE A 1 105 ? -7.49265  -38.55434 14.89081 1.000 48.62304 ? 106 ILE A CD1 1 
ATOM   782  N N   . GLN A 1 106 ? -6.67483  -37.53660 19.28518 1.000 49.19743 ? 107 GLN A N   1 
ATOM   783  C CA  . GLN A 1 106 ? -7.06056  -36.25241 19.83207 1.000 49.49940 ? 107 GLN A CA  1 
ATOM   784  C C   . GLN A 1 106 ? -6.93158  -35.16841 18.78699 1.000 43.35620 ? 107 GLN A C   1 
ATOM   785  O O   . GLN A 1 106 ? -6.25520  -35.35422 17.77319 1.000 46.26012 ? 107 GLN A O   1 
ATOM   786  C CB  . GLN A 1 106 ? -6.20004  -35.90825 21.05045 1.000 53.20953 ? 107 GLN A CB  1 
ATOM   787  C CG  . GLN A 1 106 ? -6.14369  -37.04578 22.02635 1.000 55.50560 ? 107 GLN A CG  1 
ATOM   788  C CD  . GLN A 1 106 ? -7.34655  -37.02028 22.93333 1.000 64.37847 ? 107 GLN A CD  1 
ATOM   789  O OE1 . GLN A 1 106 ? -7.74003  -35.95952 23.42917 1.000 67.34721 ? 107 GLN A OE1 1 
ATOM   790  N NE2 . GLN A 1 106 ? -7.99040  -38.17542 23.09585 1.000 66.34935 ? 107 GLN A NE2 1 
ATOM   791  N N   . PRO A 1 107 ? -7.59887  -34.02961 18.97213 1.000 46.19776 ? 108 PRO A N   1 
ATOM   792  C CA  . PRO A 1 107 ? -7.48221  -32.95821 17.97840 1.000 47.65520 ? 108 PRO A CA  1 
ATOM   793  C C   . PRO A 1 107 ? -6.03289  -32.51384 17.80082 1.000 49.10199 ? 108 PRO A C   1 
ATOM   794  O O   . PRO A 1 107 ? -5.22496  -32.53540 18.73398 1.000 49.99559 ? 108 PRO A O   1 
ATOM   795  C CB  . PRO A 1 107 ? -8.35061  -31.84003 18.55769 1.000 45.59930 ? 108 PRO A CB  1 
ATOM   796  C CG  . PRO A 1 107 ? -9.33279  -32.54289 19.42549 1.000 46.05610 ? 108 PRO A CG  1 
ATOM   797  C CD  . PRO A 1 107 ? -8.59920  -33.71107 20.01148 1.000 40.70325 ? 108 PRO A CD  1 
ATOM   798  N N   . GLY A 1 108 ? -5.70699  -32.11798 16.57683 1.000 44.72697 ? 109 GLY A N   1 
ATOM   799  C CA  . GLY A 1 108 ? -4.35027  -31.80630 16.20515 1.000 46.36359 ? 109 GLY A CA  1 
ATOM   800  C C   . GLY A 1 108 ? -3.56081  -32.98138 15.66403 1.000 44.64169 ? 109 GLY A C   1 
ATOM   801  O O   . GLY A 1 108 ? -2.66989  -32.78143 14.83460 1.000 51.18881 ? 109 GLY A O   1 
ATOM   802  N N   . GLN A 1 109 ? -3.85628  -34.19682 16.11442 1.000 41.17421 ? 110 GLN A N   1 
ATOM   803  C CA  . GLN A 1 109 ? -3.12654  -35.35226 15.63749 1.000 42.29433 ? 110 GLN A CA  1 
ATOM   804  C C   . GLN A 1 109 ? -3.46510  -35.62337 14.18100 1.000 42.52665 ? 110 GLN A C   1 
ATOM   805  O O   . GLN A 1 109 ? -4.53097  -35.25275 13.68789 1.000 41.19648 ? 110 GLN A O   1 
ATOM   806  C CB  . GLN A 1 109 ? -3.44280  -36.57710 16.47174 1.000 44.97225 ? 110 GLN A CB  1 
ATOM   807  C CG  . GLN A 1 109 ? -2.65159  -36.65246 17.75648 1.000 49.70071 ? 110 GLN A CG  1 
ATOM   808  C CD  . GLN A 1 109 ? -2.96101  -37.92088 18.53631 1.000 59.00441 ? 110 GLN A CD  1 
ATOM   809  O OE1 . GLN A 1 109 ? -3.96986  -38.00672 19.24347 1.000 55.57813 ? 110 GLN A OE1 1 
ATOM   810  N NE2 . GLN A 1 109 ? -2.09461  -38.92949 18.38907 1.000 63.12020 ? 110 GLN A NE2 1 
ATOM   811  N N   . THR A 1 110 ? -2.53018  -36.25648 13.48499 1.000 41.94590 ? 111 THR A N   1 
ATOM   812  C CA  . THR A 1 110 ? -2.65895  -36.51787 12.06258 1.000 40.75998 ? 111 THR A CA  1 
ATOM   813  C C   . THR A 1 110 ? -2.66994  -38.01749 11.82181 1.000 38.83597 ? 111 THR A C   1 
ATOM   814  O O   . THR A 1 110 ? -2.27068  -38.80717 12.68161 1.000 36.77800 ? 111 THR A O   1 
ATOM   815  C CB  . THR A 1 110 ? -1.50334  -35.88378 11.26202 1.000 41.17325 ? 111 THR A CB  1 
ATOM   816  O OG1 . THR A 1 110 ? -0.28358  -36.49650 11.66229 1.000 35.17563 ? 111 THR A OG1 1 
ATOM   817  C CG2 . THR A 1 110 ? -1.42675  -34.39020 11.52839 1.000 46.84100 ? 111 THR A CG2 1 
ATOM   818  N N   . PHE A 1 111 ? -3.09816  -38.39182 10.62076 1.000 34.89657 ? 112 PHE A N   1 
ATOM   819  C CA  . PHE A 1 111 ? -3.19364  -39.79303 10.23650 1.000 35.36689 ? 112 PHE A CA  1 
ATOM   820  C C   . PHE A 1 111 ? -3.31025  -39.85862 8.72191  1.000 35.97317 ? 112 PHE A C   1 
ATOM   821  O O   . PHE A 1 111 ? -3.59756  -38.85950 8.06401  1.000 37.18352 ? 112 PHE A O   1 
ATOM   822  C CB  . PHE A 1 111 ? -4.39622  -40.48234 10.93271 1.000 40.42462 ? 112 PHE A CB  1 
ATOM   823  C CG  . PHE A 1 111 ? -5.72394  -39.76726 10.73715 1.000 39.26097 ? 112 PHE A CG  1 
ATOM   824  C CD1 . PHE A 1 111 ? -6.12017  -38.75506 11.59403 1.000 39.59023 ? 112 PHE A CD1 1 
ATOM   825  C CD2 . PHE A 1 111 ? -6.56875  -40.11898 9.68931  1.000 40.76273 ? 112 PHE A CD2 1 
ATOM   826  C CE1 . PHE A 1 111 ? -7.34099  -38.10284 11.41824 1.000 42.23678 ? 112 PHE A CE1 1 
ATOM   827  C CE2 . PHE A 1 111 ? -7.77165  -39.47910 9.49158  1.000 36.18211 ? 112 PHE A CE2 1 
ATOM   828  C CZ  . PHE A 1 111 ? -8.16697  -38.46554 10.36508 1.000 43.75615 ? 112 PHE A CZ  1 
ATOM   829  N N   . SER A 1 112 ? -3.06546  -41.03802 8.16976  1.000 37.38480 ? 113 SER A N   1 
ATOM   830  C CA  . SER A 1 112 ? -3.28221  -41.25284 6.74483  1.000 36.63323 ? 113 SER A CA  1 
ATOM   831  C C   . SER A 1 112 ? -4.69522  -41.77940 6.50519  1.000 41.08289 ? 113 SER A C   1 
ATOM   832  O O   . SER A 1 112 ? -5.25624  -42.49599 7.32901  1.000 39.96485 ? 113 SER A O   1 
ATOM   833  C CB  . SER A 1 112 ? -2.26788  -42.24643 6.16183  1.000 40.03798 ? 113 SER A CB  1 
ATOM   834  O OG  . SER A 1 112 ? -0.94148  -41.92729 6.51891  1.000 39.03709 ? 113 SER A OG  1 
ATOM   835  N N   . VAL A 1 113 ? -5.25688  -41.42564 5.35793  1.000 38.54192 ? 114 VAL A N   1 
ATOM   836  C CA  . VAL A 1 113 ? -6.59316  -41.83796 4.96356  1.000 41.39429 ? 114 VAL A CA  1 
ATOM   837  C C   . VAL A 1 113 ? -6.45939  -42.64711 3.68174  1.000 40.20777 ? 114 VAL A C   1 
ATOM   838  O O   . VAL A 1 113 ? -5.81521  -42.19098 2.72786  1.000 35.39881 ? 114 VAL A O   1 
ATOM   839  C CB  . VAL A 1 113 ? -7.52134  -40.62448 4.73754  1.000 40.97850 ? 114 VAL A CB  1 
ATOM   840  C CG1 . VAL A 1 113 ? -8.79670  -41.07117 4.05302  1.000 39.23192 ? 114 VAL A CG1 1 
ATOM   841  C CG2 . VAL A 1 113 ? -7.82473  -39.91395 6.03169  1.000 37.18390 ? 114 VAL A CG2 1 
ATOM   842  N N   . LEU A 1 114 ? -7.05561  -43.84076 3.66237  1.000 36.25163 ? 115 LEU A N   1 
ATOM   843  C CA  . LEU A 1 114 ? -7.20206  -44.62999 2.43758  1.000 38.53134 ? 115 LEU A CA  1 
ATOM   844  C C   . LEU A 1 114 ? -8.62289  -44.43358 1.92259  1.000 41.29120 ? 115 LEU A C   1 
ATOM   845  O O   . LEU A 1 114 ? -9.57555  -45.01963 2.44876  1.000 42.86380 ? 115 LEU A O   1 
ATOM   846  C CB  . LEU A 1 114 ? -6.89623  -46.10611 2.66688  1.000 37.26170 ? 115 LEU A CB  1 
ATOM   847  C CG  . LEU A 1 114 ? -6.82401  -46.90682 1.35821  1.000 40.67639 ? 115 LEU A CG  1 
ATOM   848  C CD1 . LEU A 1 114 ? -5.64905  -46.42169 0.44695  1.000 37.77317 ? 115 LEU A CD1 1 
ATOM   849  C CD2 . LEU A 1 114 ? -6.70657  -48.39407 1.61952  1.000 44.28004 ? 115 LEU A CD2 1 
ATOM   850  N N   . ALA A 1 115 ? -8.76486  -43.58820 0.90636  1.000 36.97639 ? 116 ALA A N   1 
ATOM   851  C CA  . ALA A 1 115 ? -10.04775 -43.36142 0.27182  1.000 41.55517 ? 116 ALA A CA  1 
ATOM   852  C C   . ALA A 1 115 ? -10.39072 -44.55461 -0.61248 1.000 46.80339 ? 116 ALA A C   1 
ATOM   853  O O   . ALA A 1 115 ? -9.60017  -44.94470 -1.48845 1.000 43.71213 ? 116 ALA A O   1 
ATOM   854  C CB  . ALA A 1 115 ? -10.02912 -42.07415 -0.54757 1.000 43.53001 ? 116 ALA A CB  1 
ATOM   855  N N   . CYS A 1 116 ? -11.56887 -45.13174 -0.36691 1.000 36.91262 ? 117 CYS A N   1 
ATOM   856  C CA  . CYS A 1 116 ? -12.06611 -46.30970 -1.06641 1.000 47.82287 ? 117 CYS A CA  1 
ATOM   857  C C   . CYS A 1 116 ? -13.49030 -46.09729 -1.54781 1.000 44.36023 ? 117 CYS A C   1 
ATOM   858  O O   . CYS A 1 116 ? -14.29259 -45.40464 -0.90682 1.000 46.97582 ? 117 CYS A O   1 
ATOM   859  C CB  . CYS A 1 116 ? -12.08747 -47.55390 -0.18281 1.000 43.12568 ? 117 CYS A CB  1 
ATOM   860  S SG  . CYS A 1 116 ? -10.57714 -47.86502 0.64550  1.000 56.84108 ? 117 CYS A SG  1 
ATOM   861  N N   . TYR A 1 117 ? -13.80928 -46.75426 -2.65709 1.000 45.98262 ? 118 TYR A N   1 
ATOM   862  C CA  . TYR A 1 117 ? -15.15791 -46.75119 -3.21010 1.000 49.79201 ? 118 TYR A CA  1 
ATOM   863  C C   . TYR A 1 117 ? -15.47287 -48.16150 -3.68660 1.000 48.99853 ? 118 TYR A C   1 
ATOM   864  O O   . TYR A 1 117 ? -14.67896 -48.76502 -4.41748 1.000 48.65832 ? 118 TYR A O   1 
ATOM   865  C CB  . TYR A 1 117 ? -15.28453 -45.71276 -4.34438 1.000 50.23996 ? 118 TYR A CB  1 
ATOM   866  C CG  . TYR A 1 117 ? -14.90554 -44.31877 -3.87394 1.000 47.95742 ? 118 TYR A CG  1 
ATOM   867  C CD1 . TYR A 1 117 ? -13.58331 -43.86954 -3.93311 1.000 49.65999 ? 118 TYR A CD1 1 
ATOM   868  C CD2 . TYR A 1 117 ? -15.85847 -43.47219 -3.31678 1.000 50.06889 ? 118 TYR A CD2 1 
ATOM   869  C CE1 . TYR A 1 117 ? -13.22654 -42.60120 -3.47388 1.000 47.66776 ? 118 TYR A CE1 1 
ATOM   870  C CE2 . TYR A 1 117 ? -15.51932 -42.21104 -2.86017 1.000 50.73825 ? 118 TYR A CE2 1 
ATOM   871  C CZ  . TYR A 1 117 ? -14.19950 -41.78113 -2.94030 1.000 51.21846 ? 118 TYR A CZ  1 
ATOM   872  O OH  . TYR A 1 117 ? -13.86810 -40.52959 -2.48618 1.000 53.42480 ? 118 TYR A OH  1 
ATOM   873  N N   . ASN A 1 118 ? -16.60142 -48.70279 -3.21153 1.000 51.55366 ? 119 ASN A N   1 
ATOM   874  C CA  . ASN A 1 118 ? -17.05755 -50.04934 -3.56897 1.000 53.35203 ? 119 ASN A CA  1 
ATOM   875  C C   . ASN A 1 118 ? -16.01330 -51.10807 -3.21376 1.000 52.98979 ? 119 ASN A C   1 
ATOM   876  O O   . ASN A 1 118 ? -15.80372 -52.07227 -3.95130 1.000 55.63785 ? 119 ASN A O   1 
ATOM   877  C CB  . ASN A 1 118 ? -17.43634 -50.12693 -5.05277 1.000 52.49657 ? 119 ASN A CB  1 
ATOM   878  C CG  . ASN A 1 118 ? -18.36528 -48.99426 -5.47760 1.000 60.45512 ? 119 ASN A CG  1 
ATOM   879  O OD1 . ASN A 1 118 ? -19.55853 -48.96701 -5.12026 1.000 52.33732 ? 119 ASN A OD1 1 
ATOM   880  N ND2 . ASN A 1 118 ? -17.81763 -48.04312 -6.24091 1.000 58.63418 ? 119 ASN A ND2 1 
ATOM   881  N N   . GLY A 1 119 ? -15.35559 -50.93252 -2.06630 1.000 48.90839 ? 120 GLY A N   1 
ATOM   882  C CA  . GLY A 1 119 ? -14.31515 -51.84044 -1.63881 1.000 44.58293 ? 120 GLY A CA  1 
ATOM   883  C C   . GLY A 1 119 ? -12.97293 -51.65805 -2.31914 1.000 51.86881 ? 120 GLY A C   1 
ATOM   884  O O   . GLY A 1 119 ? -12.00542 -52.33743 -1.93418 1.000 52.51346 ? 120 GLY A O   1 
ATOM   885  N N   . SER A 1 120 ? -12.86601 -50.76167 -3.30948 1.000 51.29121 ? 121 SER A N   1 
ATOM   886  C CA  . SER A 1 120 ? -11.63703 -50.65825 -4.09151 1.000 52.80393 ? 121 SER A CA  1 
ATOM   887  C C   . SER A 1 120 ? -10.83208 -49.43886 -3.65827 1.000 48.26734 ? 121 SER A C   1 
ATOM   888  O O   . SER A 1 120 ? -11.26497 -48.29834 -3.90845 1.000 41.72166 ? 121 SER A O   1 
ATOM   889  C CB  . SER A 1 120 ? -11.95515 -50.58290 -5.58159 1.000 50.11410 ? 121 SER A CB  1 
ATOM   890  O OG  . SER A 1 120 ? -10.80703 -50.89623 -6.34777 1.000 65.89219 ? 121 SER A OG  1 
ATOM   891  N N   . PRO A 1 121 ? -9.69113  -49.61573 -2.99453 1.000 49.78430 ? 122 PRO A N   1 
ATOM   892  C CA  . PRO A 1 121 ? -8.85412  -48.45715 -2.64711 1.000 49.82389 ? 122 PRO A CA  1 
ATOM   893  C C   . PRO A 1 121 ? -8.57316  -47.59664 -3.87379 1.000 46.86438 ? 122 PRO A C   1 
ATOM   894  O O   . PRO A 1 121 ? -8.29834  -48.10715 -4.95912 1.000 49.92493 ? 122 PRO A O   1 
ATOM   895  C CB  . PRO A 1 121 ? -7.57610  -49.09642 -2.09443 1.000 41.29262 ? 122 PRO A CB  1 
ATOM   896  C CG  . PRO A 1 121 ? -8.04766  -50.43550 -1.53902 1.000 46.01454 ? 122 PRO A CG  1 
ATOM   897  C CD  . PRO A 1 121 ? -9.13752  -50.88654 -2.48081 1.000 45.93249 ? 122 PRO A CD  1 
ATOM   898  N N   . SER A 1 122 ? -8.71033  -46.27970 -3.71416 1.000 43.44903 ? 123 SER A N   1 
ATOM   899  C CA  . SER A 1 122 ? -8.45969  -45.36667 -4.81657 1.000 45.81645 ? 123 SER A CA  1 
ATOM   900  C C   . SER A 1 122 ? -7.38770  -44.31384 -4.54170 1.000 42.87599 ? 123 SER A C   1 
ATOM   901  O O   . SER A 1 122 ? -6.80446  -43.80704 -5.49981 1.000 44.36928 ? 123 SER A O   1 
ATOM   902  C CB  . SER A 1 122 ? -9.75671  -44.65933 -5.23952 1.000 46.11782 ? 123 SER A CB  1 
ATOM   903  O OG  . SER A 1 122 ? -9.99493  -43.51175 -4.45834 1.000 52.18019 ? 123 SER A OG  1 
ATOM   904  N N   . GLY A 1 123 ? -7.09221  -43.99184 -3.28636 1.000 40.49012 ? 124 GLY A N   1 
ATOM   905  C CA  . GLY A 1 123 ? -6.18711  -42.89625 -2.99486 1.000 37.76440 ? 124 GLY A CA  1 
ATOM   906  C C   . GLY A 1 123 ? -5.77599  -42.89895 -1.54264 1.000 41.66125 ? 124 GLY A C   1 
ATOM   907  O O   . GLY A 1 123 ? -6.46391  -43.46448 -0.67874 1.000 36.05442 ? 124 GLY A O   1 
ATOM   908  N N   . VAL A 1 124 ? -4.63333  -42.26106 -1.28062 1.000 37.13570 ? 125 VAL A N   1 
ATOM   909  C CA  . VAL A 1 124 ? -4.12039  -42.11975 0.07669  1.000 37.39120 ? 125 VAL A CA  1 
ATOM   910  C C   . VAL A 1 124 ? -3.58607  -40.69814 0.27424  1.000 42.65644 ? 125 VAL A C   1 
ATOM   911  O O   . VAL A 1 124 ? -2.94528  -40.12567 -0.61556 1.000 43.09650 ? 125 VAL A O   1 
ATOM   912  C CB  . VAL A 1 124 ? -3.06260  -43.19959 0.38197  1.000 35.37989 ? 125 VAL A CB  1 
ATOM   913  C CG1 . VAL A 1 124 ? -1.94938  -43.17795 -0.65383 1.000 43.20645 ? 125 VAL A CG1 1 
ATOM   914  C CG2 . VAL A 1 124 ? -2.50119  -43.01518 1.75434  1.000 36.05510 ? 125 VAL A CG2 1 
ATOM   915  N N   . TYR A 1 125 ? -3.88590  -40.11486 1.43149  1.000 39.51495 ? 126 TYR A N   1 
ATOM   916  C CA  . TYR A 1 125 ? -3.44993  -38.76111 1.74775  1.000 42.80201 ? 126 TYR A CA  1 
ATOM   917  C C   . TYR A 1 125 ? -3.46678  -38.58313 3.25889  1.000 41.49118 ? 126 TYR A C   1 
ATOM   918  O O   . TYR A 1 125 ? -4.06119  -39.36929 4.00097  1.000 39.68746 ? 126 TYR A O   1 
ATOM   919  C CB  . TYR A 1 125 ? -4.33351  -37.70317 1.07424  1.000 45.38421 ? 126 TYR A CB  1 
ATOM   920  C CG  . TYR A 1 125 ? -5.81819  -37.83698 1.40388  1.000 46.02018 ? 126 TYR A CG  1 
ATOM   921  C CD1 . TYR A 1 125 ? -6.64881  -38.64542 0.64017  1.000 44.11793 ? 126 TYR A CD1 1 
ATOM   922  C CD2 . TYR A 1 125 ? -6.37991  -37.15579 2.48743  1.000 42.98184 ? 126 TYR A CD2 1 
ATOM   923  C CE1 . TYR A 1 125 ? -8.01387  -38.76805 0.94010  1.000 48.10811 ? 126 TYR A CE1 1 
ATOM   924  C CE2 . TYR A 1 125 ? -7.72606  -37.25070 2.77976  1.000 46.08636 ? 126 TYR A CE2 1 
ATOM   925  C CZ  . TYR A 1 125 ? -8.54763  -38.06375 2.00676  1.000 47.91887 ? 126 TYR A CZ  1 
ATOM   926  O OH  . TYR A 1 125 ? -9.89721  -38.18576 2.30995  1.000 49.46550 ? 126 TYR A OH  1 
ATOM   927  N N   . GLN A 1 126 ? -2.81537  -37.52484 3.70184  1.000 37.00056 ? 127 GLN A N   1 
ATOM   928  C CA  . GLN A 1 126 ? -2.61698  -37.25248 5.11325  1.000 36.42702 ? 127 GLN A CA  1 
ATOM   929  C C   . GLN A 1 126 ? -3.60076  -36.16280 5.49900  1.000 43.64767 ? 127 GLN A C   1 
ATOM   930  O O   . GLN A 1 126 ? -3.95399  -35.32529 4.66598  1.000 44.34321 ? 127 GLN A O   1 
ATOM   931  C CB  . GLN A 1 126 ? -1.16076  -36.82409 5.37063  1.000 44.34225 ? 127 GLN A CB  1 
ATOM   932  C CG  . GLN A 1 126 ? -0.67413  -36.74277 6.81143  1.000 39.41152 ? 127 GLN A CG  1 
ATOM   933  C CD  . GLN A 1 126 ? -0.23270  -38.08284 7.39741  1.000 44.27345 ? 127 GLN A CD  1 
ATOM   934  O OE1 . GLN A 1 126 ? -0.53694  -39.15818 6.86939  1.000 42.57024 ? 127 GLN A OE1 1 
ATOM   935  N NE2 . GLN A 1 126 ? 0.50347   -38.01659 8.49828  1.000 46.98800 ? 127 GLN A NE2 1 
ATOM   936  N N   . CYS A 1 127 ? -4.10492  -36.21706 6.73109  1.000 42.15129 ? 128 CYS A N   1 
ATOM   937  C CA  . CYS A 1 127 ? -4.84632  -35.07965 7.24842  1.000 41.58348 ? 128 CYS A CA  1 
ATOM   938  C C   . CYS A 1 127 ? -4.82080  -35.12142 8.76380  1.000 40.94880 ? 128 CYS A C   1 
ATOM   939  O O   . CYS A 1 127 ? -4.15319  -35.95717 9.38357  1.000 38.23322 ? 128 CYS A O   1 
ATOM   940  C CB  . CYS A 1 127 ? -6.27775  -35.02778 6.72304  1.000 54.07462 ? 128 CYS A CB  1 
ATOM   941  S SG  . CYS A 1 127 ? -7.19142  -36.50869 6.97415  1.000 59.25782 ? 128 CYS A SG  1 
ATOM   942  N N   . ALA A 1 128 ? -5.52618  -34.16515 9.34771  1.000 41.36780 ? 129 ALA A N   1 
ATOM   943  C CA  . ALA A 1 128 ? -5.49685  -33.92101 10.77465 1.000 45.57514 ? 129 ALA A CA  1 
ATOM   944  C C   . ALA A 1 128 ? -6.92338  -33.86083 11.29500 1.000 39.10193 ? 129 ALA A C   1 
ATOM   945  O O   . ALA A 1 128 ? -7.82324  -33.36100 10.61825 1.000 38.14494 ? 129 ALA A O   1 
ATOM   946  C CB  . ALA A 1 128 ? -4.75359  -32.61045 11.10082 1.000 38.01660 ? 129 ALA A CB  1 
ATOM   947  N N   . MET A 1 129 ? -7.10732  -34.38707 12.49823 1.000 39.28058 ? 130 MET A N   1 
ATOM   948  C CA  . MET A 1 129 ? -8.33088  -34.18013 13.27515 1.000 42.99525 ? 130 MET A CA  1 
ATOM   949  C C   . MET A 1 129 ? -8.40342  -32.72872 13.74438 1.000 44.03558 ? 130 MET A C   1 
ATOM   950  O O   . MET A 1 129 ? -7.61170  -32.30642 14.59271 1.000 45.88550 ? 130 MET A O   1 
ATOM   951  C CB  . MET A 1 129 ? -8.35441  -35.13648 14.46448 1.000 43.05702 ? 130 MET A CB  1 
ATOM   952  C CG  . MET A 1 129 ? -9.50555  -34.89332 15.45253 1.000 46.65349 ? 130 MET A CG  1 
ATOM   953  S SD  . MET A 1 129 ? -11.10733 -35.33642 14.75080 1.000 47.32735 ? 130 MET A SD  1 
ATOM   954  C CE  . MET A 1 129 ? -10.81525 -37.05758 14.41718 1.000 40.91432 ? 130 MET A CE  1 
ATOM   955  N N   . ARG A 1 130 ? -9.35980  -31.96701 13.20004 1.000 44.26806 ? 131 ARG A N   1 
ATOM   956  C CA  . ARG A 1 130 ? -9.49190  -30.55115 13.50992 1.000 39.85666 ? 131 ARG A CA  1 
ATOM   957  C C   . ARG A 1 130 ? -9.94693  -30.36503 14.95841 1.000 44.56706 ? 131 ARG A C   1 
ATOM   958  O O   . ARG A 1 130 ? -10.42847 -31.30472 15.59151 1.000 46.95135 ? 131 ARG A O   1 
ATOM   959  C CB  . ARG A 1 130 ? -10.47008 -29.87328 12.54802 1.000 39.23170 ? 131 ARG A CB  1 
ATOM   960  C CG  . ARG A 1 130 ? -10.03456 -29.75613 11.05929 1.000 45.70652 ? 131 ARG A CG  1 
ATOM   961  C CD  . ARG A 1 130 ? -8.53550  -29.44679 10.87286 1.000 45.72258 ? 131 ARG A CD  1 
ATOM   962  N NE  . ARG A 1 130 ? -8.23711  -28.12233 11.39629 1.000 47.10910 ? 131 ARG A NE  1 
ATOM   963  C CZ  . ARG A 1 130 ? -7.07311  -27.49458 11.27762 1.000 51.28606 ? 131 ARG A CZ  1 
ATOM   964  N NH1 . ARG A 1 130 ? -6.07943  -28.06257 10.61201 1.000 44.06923 ? 131 ARG A NH1 1 
ATOM   965  N NH2 . ARG A 1 130 ? -6.90441  -26.30018 11.83663 1.000 45.39602 ? 131 ARG A NH2 1 
ATOM   966  N N   . PRO A 1 131 ? -9.73599  -29.17283 15.53256 1.000 47.79221 ? 132 PRO A N   1 
ATOM   967  C CA  . PRO A 1 131 ? -10.23951 -28.93114 16.89362 1.000 43.06877 ? 132 PRO A CA  1 
ATOM   968  C C   . PRO A 1 131 ? -11.75245 -29.01386 16.99610 1.000 46.94568 ? 132 PRO A C   1 
ATOM   969  O O   . PRO A 1 131 ? -12.28471 -29.38273 18.04761 1.000 45.21946 ? 132 PRO A O   1 
ATOM   970  C CB  . PRO A 1 131 ? -9.73148  -27.51525 17.20522 1.000 48.06228 ? 132 PRO A CB  1 
ATOM   971  C CG  . PRO A 1 131 ? -8.55192  -27.34324 16.37967 1.000 41.76126 ? 132 PRO A CG  1 
ATOM   972  C CD  . PRO A 1 131 ? -8.81994  -28.10199 15.10005 1.000 40.95903 ? 132 PRO A CD  1 
ATOM   973  N N   . ASN A 1 132 ? -12.46923 -28.68823 15.93720 1.000 47.25436 ? 133 ASN A N   1 
ATOM   974  C CA  . ASN A 1 132 ? -13.90821 -28.84875 15.97179 1.000 45.91097 ? 133 ASN A CA  1 
ATOM   975  C C   . ASN A 1 132 ? -14.34645 -30.28556 15.65773 1.000 47.92467 ? 133 ASN A C   1 
ATOM   976  O O   . ASN A 1 132 ? -15.52389 -30.49497 15.36652 1.000 45.44115 ? 133 ASN A O   1 
ATOM   977  C CB  . ASN A 1 132 ? -14.56415 -27.84453 15.01638 1.000 44.20850 ? 133 ASN A CB  1 
ATOM   978  C CG  . ASN A 1 132 ? -14.27622 -28.13612 13.55925 1.000 45.24752 ? 133 ASN A CG  1 
ATOM   979  O OD1 . ASN A 1 132 ? -13.53959 -29.06333 13.22573 1.000 45.55899 ? 133 ASN A OD1 1 
ATOM   980  N ND2 . ASN A 1 132 ? -14.87265 -27.34699 12.67568 1.000 47.59399 ? 133 ASN A ND2 1 
ATOM   981  N N   . HIS A 1 133 ? -13.41878 -31.25369 15.68469 1.000 46.00955 ? 134 HIS A N   1 
ATOM   982  C CA  . HIS A 1 133 ? -13.66175 -32.69580 15.59673 1.000 45.70617 ? 134 HIS A CA  1 
ATOM   983  C C   . HIS A 1 133 ? -14.08838 -33.15127 14.21562 1.000 46.12368 ? 134 HIS A C   1 
ATOM   984  O O   . HIS A 1 133 ? -14.52889 -34.29384 14.06466 1.000 48.32134 ? 134 HIS A O   1 
ATOM   985  C CB  . HIS A 1 133 ? -14.70214 -33.17747 16.62077 1.000 41.94024 ? 134 HIS A CB  1 
ATOM   986  C CG  . HIS A 1 133 ? -14.37106 -32.77742 18.01906 1.000 44.64583 ? 134 HIS A CG  1 
ATOM   987  N ND1 . HIS A 1 133 ? -14.82066 -31.60145 18.58127 1.000 52.46419 ? 134 HIS A ND1 1 
ATOM   988  C CD2 . HIS A 1 133 ? -13.56771 -33.35269 18.94147 1.000 44.50861 ? 134 HIS A CD2 1 
ATOM   989  C CE1 . HIS A 1 133 ? -14.32968 -31.48555 19.80192 1.000 48.27270 ? 134 HIS A CE1 1 
ATOM   990  N NE2 . HIS A 1 133 ? -13.56676 -32.53530 20.04398 1.000 45.52421 ? 134 HIS A NE2 1 
ATOM   991  N N   . THR A 1 134 ? -14.01422 -32.28271 13.22276 1.000 42.59773 ? 135 THR A N   1 
ATOM   992  C CA  . THR A 1 134 ? -14.17443 -32.66109 11.83351 1.000 42.71548 ? 135 THR A CA  1 
ATOM   993  C C   . THR A 1 134 ? -12.81079 -32.90390 11.20598 1.000 46.94806 ? 135 THR A C   1 
ATOM   994  O O   . THR A 1 134 ? -11.76216 -32.59360 11.78090 1.000 48.84342 ? 135 THR A O   1 
ATOM   995  C CB  . THR A 1 134 ? -14.88588 -31.56847 11.04757 1.000 45.60995 ? 135 THR A CB  1 
ATOM   996  O OG1 . THR A 1 134 ? -13.97854 -30.48205 10.86503 1.000 44.99870 ? 135 THR A OG1 1 
ATOM   997  C CG2 . THR A 1 134 ? -16.11957 -31.07441 11.78075 1.000 43.61772 ? 135 THR A CG2 1 
ATOM   998  N N   . ILE A 1 135 ? -12.82344 -33.45639 10.00104 1.000 43.74251 ? 136 ILE A N   1 
ATOM   999  C CA  . ILE A 1 135 ? -11.60256 -33.60289 9.22169  1.000 48.51769 ? 136 ILE A CA  1 
ATOM   1000 C C   . ILE A 1 135 ? -11.83762 -32.98269 7.85296  1.000 48.82748 ? 136 ILE A C   1 
ATOM   1001 O O   . ILE A 1 135 ? -12.93862 -33.07008 7.29618  1.000 48.80952 ? 136 ILE A O   1 
ATOM   1002 C CB  . ILE A 1 135 ? -11.16202 -35.07818 9.11659  1.000 50.50614 ? 136 ILE A CB  1 
ATOM   1003 C CG1 . ILE A 1 135 ? -11.92046 -35.80846 8.01752  1.000 47.03271 ? 136 ILE A CG1 1 
ATOM   1004 C CG2 . ILE A 1 135 ? -11.38198 -35.79926 10.44694 1.000 44.48512 ? 136 ILE A CG2 1 
ATOM   1005 C CD1 . ILE A 1 135 ? -11.45229 -37.25078 7.84040  1.000 52.87753 ? 136 ILE A CD1 1 
ATOM   1006 N N   . LYS A 1 136 ? -10.82473 -32.29498 7.34495  1.000 51.27454 ? 137 LYS A N   1 
ATOM   1007 C CA  . LYS A 1 136 ? -10.87441 -31.70158 6.01033  1.000 53.27576 ? 137 LYS A CA  1 
ATOM   1008 C C   . LYS A 1 136 ? -10.35578 -32.75595 5.04455  1.000 50.73218 ? 137 LYS A C   1 
ATOM   1009 O O   . LYS A 1 136 ? -9.17869  -32.77838 4.69068  1.000 56.92456 ? 137 LYS A O   1 
ATOM   1010 C CB  . LYS A 1 136 ? -10.05411 -30.41531 5.95490  1.000 54.21166 ? 137 LYS A CB  1 
ATOM   1011 C CG  . LYS A 1 136 ? -10.55164 -29.32196 6.91148  1.000 58.98180 ? 137 LYS A CG  1 
ATOM   1012 C CD  . LYS A 1 136 ? -9.80639  -27.99267 6.71941  1.000 63.46904 ? 137 LYS A CD  1 
ATOM   1013 C CE  . LYS A 1 136 ? -10.63070 -26.79664 7.20595  1.000 65.87992 ? 137 LYS A CE  1 
ATOM   1014 N NZ  . LYS A 1 136 ? -10.61755 -25.65369 6.23189  1.000 71.75548 ? 137 LYS A NZ  1 
ATOM   1015 N N   . GLY A 1 137 ? -11.24222 -33.66473 4.63866  1.000 52.66642 ? 138 GLY A N   1 
ATOM   1016 C CA  . GLY A 1 137 ? -10.89555 -34.76816 3.77509  1.000 46.38050 ? 138 GLY A CA  1 
ATOM   1017 C C   . GLY A 1 137 ? -11.34723 -34.52450 2.34426  1.000 50.10253 ? 138 GLY A C   1 
ATOM   1018 O O   . GLY A 1 137 ? -11.93897 -33.50048 2.00513  1.000 50.46623 ? 138 GLY A O   1 
ATOM   1019 N N   . SER A 1 138 ? -11.02601 -35.50211 1.49975  1.000 46.31216 ? 139 SER A N   1 
ATOM   1020 C CA  . SER A 1 138 ? -11.44859 -35.56954 0.09866  1.000 51.02605 ? 139 SER A CA  1 
ATOM   1021 C C   . SER A 1 138 ? -12.22212 -36.87813 -0.04537 1.000 52.51501 ? 139 SER A C   1 
ATOM   1022 O O   . SER A 1 138 ? -11.68134 -37.90429 -0.46894 1.000 57.68992 ? 139 SER A O   1 
ATOM   1023 C CB  . SER A 1 138 ? -10.25807 -35.50210 -0.89408 1.000 52.32548 ? 139 SER A CB  1 
ATOM   1024 O OG  . SER A 1 138 ? -9.43168  -34.38759 -0.63174 1.000 62.66220 ? 139 SER A OG  1 
ATOM   1025 N N   . PHE A 1 139 ? -13.48809 -36.83544 0.34703  1.000 48.33497 ? 140 PHE A N   1 
ATOM   1026 C CA  . PHE A 1 139 ? -14.38607 -37.97927 0.32975  1.000 52.86103 ? 140 PHE A CA  1 
ATOM   1027 C C   . PHE A 1 139 ? -15.55003 -37.65334 -0.59732 1.000 53.44882 ? 140 PHE A C   1 
ATOM   1028 O O   . PHE A 1 139 ? -16.19545 -36.61135 -0.43900 1.000 56.76623 ? 140 PHE A O   1 
ATOM   1029 C CB  . PHE A 1 139 ? -14.93134 -38.27381 1.72992  1.000 46.77314 ? 140 PHE A CB  1 
ATOM   1030 C CG  . PHE A 1 139 ? -13.94134 -38.88588 2.69196  1.000 39.44870 ? 140 PHE A CG  1 
ATOM   1031 C CD1 . PHE A 1 139 ? -13.35665 -40.10206 2.44075  1.000 39.37545 ? 140 PHE A CD1 1 
ATOM   1032 C CD2 . PHE A 1 139 ? -13.67491 -38.26399 3.90297  1.000 41.63275 ? 140 PHE A CD2 1 
ATOM   1033 C CE1 . PHE A 1 139 ? -12.48115 -40.67880 3.35391  1.000 39.44865 ? 140 PHE A CE1 1 
ATOM   1034 C CE2 . PHE A 1 139 ? -12.79657 -38.82661 4.81274  1.000 42.29158 ? 140 PHE A CE2 1 
ATOM   1035 C CZ  . PHE A 1 139 ? -12.20176 -40.04112 4.53814  1.000 37.98439 ? 140 PHE A CZ  1 
ATOM   1036 N N   . LEU A 1 140 ? -15.81599 -38.52342 -1.55836 1.000 54.46286 ? 141 LEU A N   1 
ATOM   1037 C CA  . LEU A 1 140 ? -17.00196 -38.40511 -2.39380 1.000 55.13493 ? 141 LEU A CA  1 
ATOM   1038 C C   . LEU A 1 140 ? -18.02348 -39.46510 -1.98127 1.000 55.92525 ? 141 LEU A C   1 
ATOM   1039 O O   . LEU A 1 140 ? -17.80200 -40.24251 -1.04403 1.000 55.06837 ? 141 LEU A O   1 
ATOM   1040 C CB  . LEU A 1 140 ? -16.63814 -38.52492 -3.87478 1.000 56.04581 ? 141 LEU A CB  1 
ATOM   1041 C CG  . LEU A 1 140 ? -15.44642 -37.73143 -4.43142 1.000 57.49425 ? 141 LEU A CG  1 
ATOM   1042 C CD1 . LEU A 1 140 ? -15.13934 -38.18893 -5.84355 1.000 52.40692 ? 141 LEU A CD1 1 
ATOM   1043 C CD2 . LEU A 1 140 ? -15.69349 -36.22594 -4.39862 1.000 60.03987 ? 141 LEU A CD2 1 
ATOM   1044 N N   . ASN A 1 141 ? -19.15679 -39.47672 -2.69211 1.000 56.61760 ? 142 ASN A N   1 
ATOM   1045 C CA  . ASN A 1 141 ? -20.23833 -40.41862 -2.40715 1.000 56.63653 ? 142 ASN A CA  1 
ATOM   1046 C C   . ASN A 1 141 ? -19.71627 -41.84113 -2.27980 1.000 52.46376 ? 142 ASN A C   1 
ATOM   1047 O O   . ASN A 1 141 ? -18.90102 -42.29470 -3.08278 1.000 53.92271 ? 142 ASN A O   1 
ATOM   1048 C CB  . ASN A 1 141 ? -21.30747 -40.37522 -3.50365 1.000 54.76784 ? 142 ASN A CB  1 
ATOM   1049 C CG  . ASN A 1 141 ? -22.08372 -39.07830 -3.50997 1.000 61.96378 ? 142 ASN A CG  1 
ATOM   1050 O OD1 . ASN A 1 141 ? -22.52828 -38.59989 -2.46477 1.000 60.70159 ? 142 ASN A OD1 1 
ATOM   1051 N ND2 . ASN A 1 141 ? -22.26748 -38.50820 -4.69380 1.000 64.43948 ? 142 ASN A ND2 1 
ATOM   1052 N N   . GLY A 1 142 ? -20.20124 -42.54642 -1.25974 1.000 54.94750 ? 143 GLY A N   1 
ATOM   1053 C CA  . GLY A 1 142 ? -19.77855 -43.91067 -1.04748 1.000 52.38619 ? 143 GLY A CA  1 
ATOM   1054 C C   . GLY A 1 142 ? -18.36630 -44.08470 -0.53861 1.000 49.29431 ? 143 GLY A C   1 
ATOM   1055 O O   . GLY A 1 142 ? -17.84548 -45.19834 -0.60390 1.000 48.88581 ? 143 GLY A O   1 
ATOM   1056 N N   . SER A 1 143 ? -17.72467 -43.03006 -0.02478 1.000 46.38061 ? 144 SER A N   1 
ATOM   1057 C CA  . SER A 1 143 ? -16.45275 -43.23316 0.66152  1.000 43.28732 ? 144 SER A CA  1 
ATOM   1058 C C   . SER A 1 143 ? -16.63108 -43.73323 2.08481  1.000 40.59861 ? 144 SER A C   1 
ATOM   1059 O O   . SER A 1 143 ? -15.64420 -44.18106 2.68895  1.000 36.30112 ? 144 SER A O   1 
ATOM   1060 C CB  . SER A 1 143 ? -15.62062 -41.94479 0.67258  1.000 47.92978 ? 144 SER A CB  1 
ATOM   1061 O OG  . SER A 1 143 ? -16.40654 -40.80149 0.94255  1.000 43.11174 ? 144 SER A OG  1 
ATOM   1062 N N   . CYS A 1 144 ? -17.86874 -43.69516 2.60837  1.000 41.52374 ? 145 CYS A N   1 
ATOM   1063 C CA  . CYS A 1 144 ? -18.15308 -44.15299 3.96022  1.000 35.72403 ? 145 CYS A CA  1 
ATOM   1064 C C   . CYS A 1 144 ? -17.58023 -45.53316 4.19869  1.000 33.63480 ? 145 CYS A C   1 
ATOM   1065 O O   . CYS A 1 144 ? -17.63829 -46.40726 3.33464  1.000 36.98183 ? 145 CYS A O   1 
ATOM   1066 C CB  . CYS A 1 144 ? -19.66942 -44.17784 4.22065  1.000 40.44256 ? 145 CYS A CB  1 
ATOM   1067 S SG  . CYS A 1 144 ? -20.55860 -42.79961 3.52617  1.000 46.76437 ? 145 CYS A SG  1 
ATOM   1068 N N   . GLY A 1 145 ? -17.02059 -45.72396 5.38520  1.000 37.67660 ? 146 GLY A N   1 
ATOM   1069 C CA  . GLY A 1 145 ? -16.26825 -46.91084 5.68189  1.000 36.83796 ? 146 GLY A CA  1 
ATOM   1070 C C   . GLY A 1 145 ? -14.77067 -46.78045 5.43695  1.000 38.00176 ? 146 GLY A C   1 
ATOM   1071 O O   . GLY A 1 145 ? -14.00470 -47.53378 6.03915  1.000 41.27910 ? 146 GLY A O   1 
ATOM   1072 N N   . SER A 1 146 ? -14.32920 -45.85868 4.56689  1.000 37.03891 ? 147 SER A N   1 
ATOM   1073 C CA  . SER A 1 146 ? -12.87976 -45.58982 4.44959  1.000 40.86912 ? 147 SER A CA  1 
ATOM   1074 C C   . SER A 1 146 ? -12.31665 -45.31189 5.83283  1.000 39.78560 ? 147 SER A C   1 
ATOM   1075 O O   . SER A 1 146 ? -13.02098 -44.77650 6.70079  1.000 40.14064 ? 147 SER A O   1 
ATOM   1076 C CB  . SER A 1 146 ? -12.58638 -44.38878 3.55426  1.000 35.39513 ? 147 SER A CB  1 
ATOM   1077 O OG  . SER A 1 146 ? -13.01757 -44.59895 2.22626  1.000 41.37909 ? 147 SER A OG  1 
ATOM   1078 N N   . VAL A 1 147 ? -11.07855 -45.73673 6.06524  1.000 35.08264 ? 148 VAL A N   1 
ATOM   1079 C CA  . VAL A 1 147 ? -10.49068 -45.60821 7.38929  1.000 36.23945 ? 148 VAL A CA  1 
ATOM   1080 C C   . VAL A 1 147 ? -9.23590  -44.73658 7.33232  1.000 41.00755 ? 148 VAL A C   1 
ATOM   1081 O O   . VAL A 1 147 ? -8.60362  -44.56292 6.28887  1.000 36.12917 ? 148 VAL A O   1 
ATOM   1082 C CB  . VAL A 1 147 ? -10.16544 -46.97299 8.03595  1.000 36.85950 ? 148 VAL A CB  1 
ATOM   1083 C CG1 . VAL A 1 147 ? -11.44875 -47.81747 8.22218  1.000 37.85580 ? 148 VAL A CG1 1 
ATOM   1084 C CG2 . VAL A 1 147 ? -9.12110  -47.72413 7.25626  1.000 28.08530 ? 148 VAL A CG2 1 
ATOM   1085 N N   . GLY A 1 148 ? -8.90477  -44.17964 8.49425  1.000 37.28683 ? 149 GLY A N   1 
ATOM   1086 C CA  . GLY A 1 148 ? -7.69063  -43.41987 8.68043  1.000 36.30811 ? 149 GLY A CA  1 
ATOM   1087 C C   . GLY A 1 148 ? -6.82430  -44.13710 9.69911  1.000 41.48954 ? 149 GLY A C   1 
ATOM   1088 O O   . GLY A 1 148 ? -7.32909  -44.84813 10.57313 1.000 42.06312 ? 149 GLY A O   1 
ATOM   1089 N N   . PHE A 1 149 ? -5.51242  -43.95584 9.58011  1.000 39.46852 ? 150 PHE A N   1 
ATOM   1090 C CA  . PHE A 1 149 ? -4.61582  -44.85944 10.28518 1.000 40.54702 ? 150 PHE A CA  1 
ATOM   1091 C C   . PHE A 1 149 ? -3.21079  -44.27663 10.39490 1.000 40.57977 ? 150 PHE A C   1 
ATOM   1092 O O   . PHE A 1 149 ? -2.79049  -43.45700 9.57319  1.000 39.54468 ? 150 PHE A O   1 
ATOM   1093 C CB  . PHE A 1 149 ? -4.55172  -46.22099 9.57648  1.000 40.80396 ? 150 PHE A CB  1 
ATOM   1094 C CG  . PHE A 1 149 ? -4.06149  -46.14550 8.16154  1.000 39.63031 ? 150 PHE A CG  1 
ATOM   1095 C CD1 . PHE A 1 149 ? -4.88341  -45.67517 7.15081  1.000 40.30142 ? 150 PHE A CD1 1 
ATOM   1096 C CD2 . PHE A 1 149 ? -2.76809  -46.53892 7.83800  1.000 42.70612 ? 150 PHE A CD2 1 
ATOM   1097 C CE1 . PHE A 1 149 ? -4.42747  -45.59111 5.83145  1.000 39.25957 ? 150 PHE A CE1 1 
ATOM   1098 C CE2 . PHE A 1 149 ? -2.29820  -46.45960 6.52277  1.000 42.89991 ? 150 PHE A CE2 1 
ATOM   1099 C CZ  . PHE A 1 149 ? -3.12964  -45.99563 5.51392  1.000 38.62485 ? 150 PHE A CZ  1 
ATOM   1100 N N   . ASN A 1 150 ? -2.48988  -44.74909 11.41278 1.000 40.92534 ? 151 ASN A N   1 
ATOM   1101 C CA  . ASN A 1 150 ? -1.05889  -44.56574 11.56588 1.000 43.79844 ? 151 ASN A CA  1 
ATOM   1102 C C   . ASN A 1 150 ? -0.40033  -45.92830 11.72568 1.000 48.64880 ? 151 ASN A C   1 
ATOM   1103 O O   . ASN A 1 150 ? -1.01912  -46.88000 12.23091 1.000 41.61382 ? 151 ASN A O   1 
ATOM   1104 C CB  . ASN A 1 150 ? -0.73685  -43.66054 12.76537 1.000 43.48603 ? 151 ASN A CB  1 
ATOM   1105 C CG  . ASN A 1 150 ? -1.14293  -42.22040 12.51155 1.000 45.70522 ? 151 ASN A CG  1 
ATOM   1106 O OD1 . ASN A 1 150 ? -0.65459  -41.59971 11.57444 1.000 49.09404 ? 151 ASN A OD1 1 
ATOM   1107 N ND2 . ASN A 1 150 ? -2.05501  -41.69497 13.31667 1.000 39.78378 ? 151 ASN A ND2 1 
ATOM   1108 N N   . ILE A 1 151 ? 0.85302   -46.01632 11.25792 1.000 45.11810 ? 152 ILE A N   1 
ATOM   1109 C CA  . ILE A 1 151 ? 1.65321   -47.24132 11.29739 1.000 48.33888 ? 152 ILE A CA  1 
ATOM   1110 C C   . ILE A 1 151 ? 2.91708   -46.97489 12.10044 1.000 50.69077 ? 152 ILE A C   1 
ATOM   1111 O O   . ILE A 1 151 ? 3.66457   -46.04096 11.79186 1.000 49.15098 ? 152 ILE A O   1 
ATOM   1112 C CB  . ILE A 1 151 ? 2.02672   -47.74244 9.89584  1.000 51.83664 ? 152 ILE A CB  1 
ATOM   1113 C CG1 . ILE A 1 151 ? 0.79342   -47.87737 9.01103  1.000 46.11082 ? 152 ILE A CG1 1 
ATOM   1114 C CG2 . ILE A 1 151 ? 2.77814   -49.07991 9.98644  1.000 51.14099 ? 152 ILE A CG2 1 
ATOM   1115 C CD1 . ILE A 1 151 ? 1.12895   -48.44200 7.64866  1.000 44.59797 ? 152 ILE A CD1 1 
ATOM   1116 N N   . ASP A 1 152 ? 3.15386   -47.79472 13.12441 1.000 57.77948 ? 153 ASP A N   1 
ATOM   1117 C CA  . ASP A 1 152 ? 4.39144   -47.78408 13.89876 1.000 61.89290 ? 153 ASP A CA  1 
ATOM   1118 C C   . ASP A 1 152 ? 4.96819   -49.19548 13.91737 1.000 60.59211 ? 153 ASP A C   1 
ATOM   1119 O O   . ASP A 1 152 ? 4.28401   -50.14184 14.32400 1.000 63.08761 ? 153 ASP A O   1 
ATOM   1120 C CB  . ASP A 1 152 ? 4.14747   -47.28104 15.32643 1.000 60.87157 ? 153 ASP A CB  1 
ATOM   1121 N N   . TYR A 1 153 ? 6.21775   -49.33514 13.47032 1.000 63.45923 ? 154 TYR A N   1 
ATOM   1122 C CA  . TYR A 1 153 ? 6.86786   -50.63928 13.28284 1.000 65.87349 ? 154 TYR A CA  1 
ATOM   1123 C C   . TYR A 1 153 ? 6.01463   -51.41541 12.28645 1.000 62.98412 ? 154 TYR A C   1 
ATOM   1124 O O   . TYR A 1 153 ? 5.87625   -50.96062 11.13856 1.000 67.98294 ? 154 TYR A O   1 
ATOM   1125 C CB  . TYR A 1 153 ? 7.09880   -51.31456 14.63895 1.000 63.88505 ? 154 TYR A CB  1 
ATOM   1126 N N   . ASP A 1 154 ? 5.43306   -52.55559 12.64825 1.000 56.39564 ? 155 ASP A N   1 
ATOM   1127 C CA  . ASP A 1 154 ? 4.54943   -53.28436 11.74774 1.000 59.92078 ? 155 ASP A CA  1 
ATOM   1128 C C   . ASP A 1 154 ? 3.08239   -53.16679 12.16127 1.000 60.67351 ? 155 ASP A C   1 
ATOM   1129 O O   . ASP A 1 154 ? 2.23969   -53.91263 11.65048 1.000 59.17002 ? 155 ASP A O   1 
ATOM   1130 C CB  . ASP A 1 154 ? 4.95791   -54.75733 11.68074 1.000 59.69718 ? 155 ASP A CB  1 
ATOM   1131 N N   . CYS A 1 155 ? 2.75995   -52.23478 13.06752 1.000 55.38129 ? 156 CYS A N   1 
ATOM   1132 C CA  . CYS A 1 155 ? 1.49028   -52.23246 13.78731 1.000 61.57525 ? 156 CYS A CA  1 
ATOM   1133 C C   . CYS A 1 155 ? 0.58907   -51.08840 13.32276 1.000 57.20479 ? 156 CYS A C   1 
ATOM   1134 O O   . CYS A 1 155 ? 0.85231   -49.91272 13.61148 1.000 52.88710 ? 156 CYS A O   1 
ATOM   1135 C CB  . CYS A 1 155 ? 1.72928   -52.14025 15.28959 1.000 59.64505 ? 156 CYS A CB  1 
ATOM   1136 S SG  . CYS A 1 155 ? 0.19150   -52.16485 16.20633 1.000 62.67208 ? 156 CYS A SG  1 
ATOM   1137 N N   . VAL A 1 156 ? -0.50216  -51.44030 12.66036 1.000 52.53770 ? 157 VAL A N   1 
ATOM   1138 C CA  . VAL A 1 156 ? -1.46970  -50.44529 12.20819 1.000 53.23424 ? 157 VAL A CA  1 
ATOM   1139 C C   . VAL A 1 156 ? -2.35379  -50.00622 13.37767 1.000 53.11553 ? 157 VAL A C   1 
ATOM   1140 O O   . VAL A 1 156 ? -2.86014  -50.83300 14.14354 1.000 52.50979 ? 157 VAL A O   1 
ATOM   1141 C CB  . VAL A 1 156 ? -2.29493  -51.00818 11.04453 1.000 52.00572 ? 157 VAL A CB  1 
ATOM   1142 C CG1 . VAL A 1 156 ? -3.12640  -49.91038 10.39241 1.000 46.35839 ? 157 VAL A CG1 1 
ATOM   1143 C CG2 . VAL A 1 156 ? -1.33967  -51.69638 10.03144 1.000 47.05120 ? 157 VAL A CG2 1 
ATOM   1144 N N   . SER A 1 157 ? -2.49657  -48.69183 13.54113 1.000 51.80853 ? 158 SER A N   1 
ATOM   1145 C CA  . SER A 1 157 ? -3.35001  -48.06495 14.54462 1.000 44.01872 ? 158 SER A CA  1 
ATOM   1146 C C   . SER A 1 157 ? -4.48315  -47.39474 13.78659 1.000 48.06948 ? 158 SER A C   1 
ATOM   1147 O O   . SER A 1 157 ? -4.31052  -46.29739 13.25096 1.000 44.27232 ? 158 SER A O   1 
ATOM   1148 C CB  . SER A 1 157 ? -2.59817  -47.03354 15.38314 1.000 44.83035 ? 158 SER A CB  1 
ATOM   1149 O OG  . SER A 1 157 ? -1.90243  -47.63336 16.46627 1.000 52.92996 ? 158 SER A OG  1 
ATOM   1150 N N   . PHE A 1 158 ? -5.64132  -48.05879 13.74980 1.000 46.89026 ? 159 PHE A N   1 
ATOM   1151 C CA  . PHE A 1 158 ? -6.84043  -47.48936 13.15865 1.000 44.31836 ? 159 PHE A CA  1 
ATOM   1152 C C   . PHE A 1 158 ? -7.43449  -46.47513 14.12659 1.000 42.04651 ? 159 PHE A C   1 
ATOM   1153 O O   . PHE A 1 158 ? -7.68366  -46.80085 15.29022 1.000 42.07270 ? 159 PHE A O   1 
ATOM   1154 C CB  . PHE A 1 158 ? -7.85537  -48.59544 12.84739 1.000 43.05445 ? 159 PHE A CB  1 
ATOM   1155 C CG  . PHE A 1 158 ? -7.36598  -49.60029 11.84879 1.000 37.56689 ? 159 PHE A CG  1 
ATOM   1156 C CD1 . PHE A 1 158 ? -7.43218  -49.33300 10.48777 1.000 40.19308 ? 159 PHE A CD1 1 
ATOM   1157 C CD2 . PHE A 1 158 ? -6.81556  -50.79986 12.26911 1.000 39.88809 ? 159 PHE A CD2 1 
ATOM   1158 C CE1 . PHE A 1 158 ? -6.95836  -50.24382 9.55678  1.000 37.79788 ? 159 PHE A CE1 1 
ATOM   1159 C CE2 . PHE A 1 158 ? -6.33936  -51.73157 11.34867 1.000 39.91718 ? 159 PHE A CE2 1 
ATOM   1160 C CZ  . PHE A 1 158 ? -6.41798  -51.45828 9.98519  1.000 40.95383 ? 159 PHE A CZ  1 
ATOM   1161 N N   . CYS A 1 159 ? -7.65550  -45.24455 13.64842 1.000 38.59756 ? 160 CYS A N   1 
ATOM   1162 C CA  . CYS A 1 159 ? -8.19278  -44.18522 14.49229 1.000 41.09897 ? 160 CYS A CA  1 
ATOM   1163 C C   . CYS A 1 159 ? -9.49237  -43.55415 13.99920 1.000 40.25730 ? 160 CYS A C   1 
ATOM   1164 O O   . CYS A 1 159 ? -10.17871 -42.91820 14.80709 1.000 44.77590 ? 160 CYS A O   1 
ATOM   1165 C CB  . CYS A 1 159 ? -7.15870  -43.06001 14.68527 1.000 41.54873 ? 160 CYS A CB  1 
ATOM   1166 S SG  . CYS A 1 159 ? -6.51933  -42.37238 13.15752 1.000 44.42318 ? 160 CYS A SG  1 
ATOM   1167 N N   . TYR A 1 160 ? -9.86235  -43.71780 12.72958 1.000 36.07093 ? 161 TYR A N   1 
ATOM   1168 C CA  . TYR A 1 160 ? -11.04294 -43.06682 12.17461 1.000 34.50799 ? 161 TYR A CA  1 
ATOM   1169 C C   . TYR A 1 160 ? -11.71664 -43.98019 11.16615 1.000 38.10066 ? 161 TYR A C   1 
ATOM   1170 O O   . TYR A 1 160 ? -11.04132 -44.66693 10.39420 1.000 40.53149 ? 161 TYR A O   1 
ATOM   1171 C CB  . TYR A 1 160 ? -10.68123 -41.75493 11.49171 1.000 36.88220 ? 161 TYR A CB  1 
ATOM   1172 C CG  . TYR A 1 160 ? -11.78421 -40.99255 10.74478 1.000 35.95657 ? 161 TYR A CG  1 
ATOM   1173 C CD1 . TYR A 1 160 ? -12.53684 -40.01512 11.38461 1.000 35.73130 ? 161 TYR A CD1 1 
ATOM   1174 C CD2 . TYR A 1 160 ? -12.00229 -41.18569 9.39411  1.000 35.31714 ? 161 TYR A CD2 1 
ATOM   1175 C CE1 . TYR A 1 160 ? -13.49268 -39.28411 10.70388 1.000 33.75556 ? 161 TYR A CE1 1 
ATOM   1176 C CE2 . TYR A 1 160 ? -12.94078 -40.45198 8.70845  1.000 31.42404 ? 161 TYR A CE2 1 
ATOM   1177 C CZ  . TYR A 1 160 ? -13.69028 -39.50734 9.36826  1.000 32.23430 ? 161 TYR A CZ  1 
ATOM   1178 O OH  . TYR A 1 160 ? -14.63376 -38.75645 8.69236  1.000 37.57696 ? 161 TYR A OH  1 
ATOM   1179 N N   . MET A 1 161 ? -13.04717 -43.99345 11.18274 1.000 34.70707 ? 162 MET A N   1 
ATOM   1180 C CA  . MET A 1 161 ? -13.81888 -44.51616 10.07287 1.000 35.21587 ? 162 MET A CA  1 
ATOM   1181 C C   . MET A 1 161 ? -14.73620 -43.40740 9.57966  1.000 36.44813 ? 162 MET A C   1 
ATOM   1182 O O   . MET A 1 161 ? -15.33827 -42.69192 10.38124 1.000 40.17082 ? 162 MET A O   1 
ATOM   1183 C CB  . MET A 1 161 ? -14.61459 -45.75933 10.47929 1.000 36.66830 ? 162 MET A CB  1 
ATOM   1184 C CG  . MET A 1 161 ? -15.42919 -46.33678 9.33304  1.000 39.63904 ? 162 MET A CG  1 
ATOM   1185 S SD  . MET A 1 161 ? -16.08098 -47.98261 9.65700  1.000 53.07434 ? 162 MET A SD  1 
ATOM   1186 C CE  . MET A 1 161 ? -14.75687 -49.01548 9.02440  1.000 33.54348 ? 162 MET A CE  1 
ATOM   1187 N N   . HIS A 1 162 ? -14.80329 -43.22561 8.26924  1.000 35.58653 ? 163 HIS A N   1 
ATOM   1188 C CA  . HIS A 1 162 ? -15.60715 -42.14960 7.70787  1.000 34.15907 ? 163 HIS A CA  1 
ATOM   1189 C C   . HIS A 1 162 ? -17.07961 -42.54358 7.61544  1.000 39.08861 ? 163 HIS A C   1 
ATOM   1190 O O   . HIS A 1 162 ? -17.40410 -43.62481 7.11844  1.000 35.59485 ? 163 HIS A O   1 
ATOM   1191 C CB  . HIS A 1 162 ? -15.12310 -41.79864 6.31396  1.000 30.67470 ? 163 HIS A CB  1 
ATOM   1192 C CG  . HIS A 1 162 ? -15.89766 -40.68485 5.69168  1.000 34.94428 ? 163 HIS A CG  1 
ATOM   1193 N ND1 . HIS A 1 162 ? -16.08410 -39.47347 6.31928  1.000 35.19350 ? 163 HIS A ND1 1 
ATOM   1194 C CD2 . HIS A 1 162 ? -16.53541 -40.59497 4.50334  1.000 37.62068 ? 163 HIS A CD2 1 
ATOM   1195 C CE1 . HIS A 1 162 ? -16.79903 -38.68275 5.54102  1.000 38.24846 ? 163 HIS A CE1 1 
ATOM   1196 N NE2 . HIS A 1 162 ? -17.08548 -39.34031 4.43329  1.000 36.25510 ? 163 HIS A NE2 1 
ATOM   1197 N N   . HIS A 1 163 ? -17.96214 -41.62084 8.02289  1.000 39.87115 ? 164 HIS A N   1 
ATOM   1198 C CA  . HIS A 1 163 ? -19.41236 -41.79128 7.97375  1.000 41.97044 ? 164 HIS A CA  1 
ATOM   1199 C C   . HIS A 1 163 ? -20.10429 -40.76189 7.09140  1.000 46.91326 ? 164 HIS A C   1 
ATOM   1200 O O   . HIS A 1 163 ? -20.95617 -41.13449 6.27542  1.000 47.36942 ? 164 HIS A O   1 
ATOM   1201 C CB  . HIS A 1 163 ? -20.00503 -41.74083 9.39206  1.000 40.02987 ? 164 HIS A CB  1 
ATOM   1202 C CG  . HIS A 1 163 ? -19.61480 -42.90491 10.25202 1.000 43.05870 ? 164 HIS A CG  1 
ATOM   1203 N ND1 . HIS A 1 163 ? -20.53227 -43.80906 10.75126 1.000 40.52053 ? 164 HIS A ND1 1 
ATOM   1204 C CD2 . HIS A 1 163 ? -18.40353 -43.30845 10.71021 1.000 40.11223 ? 164 HIS A CD2 1 
ATOM   1205 C CE1 . HIS A 1 163 ? -19.90560 -44.72195 11.47309 1.000 40.85817 ? 164 HIS A CE1 1 
ATOM   1206 N NE2 . HIS A 1 163 ? -18.61237 -44.44253 11.46415 1.000 45.09616 ? 164 HIS A NE2 1 
ATOM   1207 N N   . MET A 1 164 ? -19.76771 -39.47616 7.19927  1.000 42.11165 ? 165 MET A N   1 
ATOM   1208 C CA  . MET A 1 164 ? -20.65217 -38.51082 6.56130  1.000 47.05412 ? 165 MET A CA  1 
ATOM   1209 C C   . MET A 1 164 ? -19.96913 -37.17289 6.31216  1.000 46.68215 ? 165 MET A C   1 
ATOM   1210 O O   . MET A 1 164 ? -19.02442 -36.78819 7.01117  1.000 46.57558 ? 165 MET A O   1 
ATOM   1211 C CB  . MET A 1 164 ? -21.90576 -38.27722 7.41034  1.000 45.71711 ? 165 MET A CB  1 
ATOM   1212 C CG  . MET A 1 164 ? -21.57942 -37.91446 8.84260  1.000 46.61230 ? 165 MET A CG  1 
ATOM   1213 S SD  . MET A 1 164 ? -23.04154 -37.83648 9.88079  1.000 56.85901 ? 165 MET A SD  1 
ATOM   1214 C CE  . MET A 1 164 ? -24.08892 -36.80031 8.84757  1.000 49.17065 ? 165 MET A CE  1 
ATOM   1215 N N   . GLU A 1 165 ? -20.49886 -36.46874 5.31416  1.000 40.87994 ? 166 GLU A N   1 
ATOM   1216 C CA  . GLU A 1 165 ? -20.15718 -35.09426 5.01998  1.000 47.90416 ? 166 GLU A CA  1 
ATOM   1217 C C   . GLU A 1 165 ? -21.10702 -34.14112 5.73761  1.000 53.86409 ? 166 GLU A C   1 
ATOM   1218 O O   . GLU A 1 165 ? -22.31941 -34.37270 5.79141  1.000 51.78490 ? 166 GLU A O   1 
ATOM   1219 C CB  . GLU A 1 165 ? -20.22861 -34.86489 3.51409  1.000 52.86179 ? 166 GLU A CB  1 
ATOM   1220 C CG  . GLU A 1 165 ? -19.64473 -33.54160 3.04375  1.000 55.85657 ? 166 GLU A CG  1 
ATOM   1221 C CD  . GLU A 1 165 ? -19.51111 -33.48643 1.53142  1.000 60.40393 ? 166 GLU A CD  1 
ATOM   1222 O OE1 . GLU A 1 165 ? -20.35299 -32.82892 0.88783  1.000 68.48616 ? 166 GLU A OE1 1 
ATOM   1223 O OE2 . GLU A 1 165 ? -18.56124 -34.09733 0.99017  1.000 64.82821 ? 166 GLU A OE2 1 
ATOM   1224 N N   . LEU A 1 166 ? -20.54470 -33.08069 6.30276  1.000 52.42229 ? 167 LEU A N   1 
ATOM   1225 C CA  . LEU A 1 166 ? -21.27100 -31.99952 6.94756  1.000 51.56730 ? 167 LEU A CA  1 
ATOM   1226 C C   . LEU A 1 166 ? -21.45466 -30.86750 5.95989  1.000 55.09884 ? 167 LEU A C   1 
ATOM   1227 O O   . LEU A 1 166 ? -20.78543 -30.83116 4.92449  1.000 54.21193 ? 167 LEU A O   1 
ATOM   1228 C CB  . LEU A 1 166 ? -20.50933 -31.49827 8.17169  1.000 52.03090 ? 167 LEU A CB  1 
ATOM   1229 C CG  . LEU A 1 166 ? -20.35954 -32.51385 9.28757  1.000 52.24476 ? 167 LEU A CG  1 
ATOM   1230 C CD1 . LEU A 1 166 ? -19.49114 -31.88543 10.35413 1.000 50.10334 ? 167 LEU A CD1 1 
ATOM   1231 C CD2 . LEU A 1 166 ? -21.72937 -32.86197 9.82468  1.000 52.56462 ? 167 LEU A CD2 1 
ATOM   1232 N N   . PRO A 1 167 ? -22.35510 -29.92048 6.23049  1.000 55.19716 ? 168 PRO A N   1 
ATOM   1233 C CA  . PRO A 1 167 ? -22.71782 -28.95693 5.17470  1.000 60.74719 ? 168 PRO A CA  1 
ATOM   1234 C C   . PRO A 1 167 ? -21.56433 -28.09996 4.65304  1.000 61.06485 ? 168 PRO A C   1 
ATOM   1235 O O   . PRO A 1 167 ? -21.63501 -27.65286 3.50248  1.000 63.76542 ? 168 PRO A O   1 
ATOM   1236 C CB  . PRO A 1 167 ? -23.82198 -28.10499 5.82843  1.000 60.30387 ? 168 PRO A CB  1 
ATOM   1237 C CG  . PRO A 1 167 ? -23.87649 -28.51434 7.26769  1.000 64.76303 ? 168 PRO A CG  1 
ATOM   1238 C CD  . PRO A 1 167 ? -23.30889 -29.88820 7.35216  1.000 61.11693 ? 168 PRO A CD  1 
ATOM   1239 N N   . THR A 1 168 ? -20.50185 -27.86621 5.42624  1.000 57.04791 ? 169 THR A N   1 
ATOM   1240 C CA  . THR A 1 168 ? -19.39746 -27.05069 4.91529  1.000 58.73452 ? 169 THR A CA  1 
ATOM   1241 C C   . THR A 1 168 ? -18.41980 -27.82654 4.03323  1.000 58.24366 ? 169 THR A C   1 
ATOM   1242 O O   . THR A 1 168 ? -17.45707 -27.23604 3.53629  1.000 60.93425 ? 169 THR A O   1 
ATOM   1243 C CB  . THR A 1 168 ? -18.63261 -26.40592 6.07269  1.000 62.32050 ? 169 THR A CB  1 
ATOM   1244 O OG1 . THR A 1 168 ? -18.52199 -27.34686 7.15140  1.000 61.99760 ? 169 THR A OG1 1 
ATOM   1245 C CG2 . THR A 1 168 ? -19.37173 -25.14481 6.56342  1.000 62.64952 ? 169 THR A CG2 1 
ATOM   1246 N N   . GLY A 1 169 ? -18.63986 -29.11902 3.81396  1.000 56.42520 ? 170 GLY A N   1 
ATOM   1247 C CA  . GLY A 1 169 ? -17.73994 -29.92400 3.02671  1.000 53.84727 ? 170 GLY A CA  1 
ATOM   1248 C C   . GLY A 1 169 ? -16.67731 -30.66040 3.81469  1.000 53.45994 ? 170 GLY A C   1 
ATOM   1249 O O   . GLY A 1 169 ? -15.88519 -31.39806 3.21256  1.000 52.84086 ? 170 GLY A O   1 
ATOM   1250 N N   . VAL A 1 170 ? -16.61793 -30.46690 5.13001  1.000 50.79353 ? 171 VAL A N   1 
ATOM   1251 C CA  . VAL A 1 170 ? -15.74426 -31.24426 6.00079  1.000 47.24418 ? 171 VAL A CA  1 
ATOM   1252 C C   . VAL A 1 170 ? -16.48251 -32.52662 6.36951  1.000 49.97590 ? 171 VAL A C   1 
ATOM   1253 O O   . VAL A 1 170 ? -17.60108 -32.76163 5.90900  1.000 50.20313 ? 171 VAL A O   1 
ATOM   1254 C CB  . VAL A 1 170 ? -15.34327 -30.43913 7.25051  1.000 46.79190 ? 171 VAL A CB  1 
ATOM   1255 C CG1 . VAL A 1 170 ? -14.54881 -29.21619 6.84422  1.000 48.83949 ? 171 VAL A CG1 1 
ATOM   1256 C CG2 . VAL A 1 170 ? -16.59202 -30.03057 8.07041  1.000 44.65531 ? 171 VAL A CG2 1 
ATOM   1257 N N   . HIS A 1 171 ? -15.89310 -33.34250 7.23098  1.000 48.30397 ? 172 HIS A N   1 
ATOM   1258 C CA  . HIS A 1 171 ? -16.29443 -34.73277 7.32425  1.000 44.37918 ? 172 HIS A CA  1 
ATOM   1259 C C   . HIS A 1 171 ? -16.31114 -35.20492 8.76230  1.000 44.16270 ? 172 HIS A C   1 
ATOM   1260 O O   . HIS A 1 171 ? -15.51162 -34.75313 9.58976  1.000 41.24594 ? 172 HIS A O   1 
ATOM   1261 C CB  . HIS A 1 171 ? -15.35758 -35.60487 6.49143  1.000 42.12300 ? 172 HIS A CB  1 
ATOM   1262 C CG  . HIS A 1 171 ? -15.39631 -35.27770 5.03523  1.000 44.31863 ? 172 HIS A CG  1 
ATOM   1263 N ND1 . HIS A 1 171 ? -14.36655 -34.62884 4.38837  1.000 49.89179 ? 172 HIS A ND1 1 
ATOM   1264 C CD2 . HIS A 1 171 ? -16.36184 -35.47523 4.10650  1.000 46.50721 ? 172 HIS A CD2 1 
ATOM   1265 C CE1 . HIS A 1 171 ? -14.68346 -34.46993 3.11535  1.000 51.30368 ? 172 HIS A CE1 1 
ATOM   1266 N NE2 . HIS A 1 171 ? -15.89367 -34.96455 2.92034  1.000 52.70822 ? 172 HIS A NE2 1 
ATOM   1267 N N   . ALA A 1 172 ? -17.23640 -36.11471 9.05157  1.000 38.40564 ? 173 ALA A N   1 
ATOM   1268 C CA  . ALA A 1 172 ? -17.36531 -36.66532 10.38614 1.000 37.48382 ? 173 ALA A CA  1 
ATOM   1269 C C   . ALA A 1 172 ? -17.30439 -38.18694 10.33884 1.000 37.90815 ? 173 ALA A C   1 
ATOM   1270 O O   . ALA A 1 172 ? -17.67887 -38.82569 9.35002  1.000 34.50623 ? 173 ALA A O   1 
ATOM   1271 C CB  . ALA A 1 172 ? -18.66517 -36.18105 11.04977 1.000 44.49115 ? 173 ALA A CB  1 
ATOM   1272 N N   . GLY A 1 173 ? -16.81818 -38.76046 11.42125 1.000 34.26039 ? 174 GLY A N   1 
ATOM   1273 C CA  . GLY A 1 173 ? -16.74684 -40.19126 11.50890 1.000 33.28749 ? 174 GLY A CA  1 
ATOM   1274 C C   . GLY A 1 173 ? -16.47853 -40.59997 12.93429 1.000 37.12935 ? 174 GLY A C   1 
ATOM   1275 O O   . GLY A 1 173 ? -16.57815 -39.79549 13.86304 1.000 36.21708 ? 174 GLY A O   1 
ATOM   1276 N N   . THR A 1 174 ? -16.09954 -41.85807 13.09278 1.000 33.20706 ? 175 THR A N   1 
ATOM   1277 C CA  . THR A 1 174 ? -15.95159 -42.45583 14.39951 1.000 32.82502 ? 175 THR A CA  1 
ATOM   1278 C C   . THR A 1 174 ? -14.58371 -43.08873 14.55116 1.000 37.73354 ? 175 THR A C   1 
ATOM   1279 O O   . THR A 1 174 ? -13.84359 -43.30532 13.57490 1.000 37.06374 ? 175 THR A O   1 
ATOM   1280 C CB  . THR A 1 174 ? -17.02958 -43.54053 14.62019 1.000 41.16784 ? 175 THR A CB  1 
ATOM   1281 O OG1 . THR A 1 174 ? -16.76328 -44.65290 13.75580 1.000 34.51597 ? 175 THR A OG1 1 
ATOM   1282 C CG2 . THR A 1 174 ? -18.40921 -42.97550 14.32171 1.000 37.17220 ? 175 THR A CG2 1 
ATOM   1283 N N   . ASP A 1 175 ? -14.27290 -43.44377 15.79119 1.000 38.85149 ? 176 ASP A N   1 
ATOM   1284 C CA  . ASP A 1 175 ? -13.20122 -44.40801 16.00091 1.000 42.13969 ? 176 ASP A CA  1 
ATOM   1285 C C   . ASP A 1 175 ? -13.73484 -45.79116 15.60895 1.000 40.38340 ? 176 ASP A C   1 
ATOM   1286 O O   . ASP A 1 175 ? -14.80094 -45.93719 15.00289 1.000 40.98638 ? 176 ASP A O   1 
ATOM   1287 C CB  . ASP A 1 175 ? -12.65602 -44.33555 17.43432 1.000 42.17831 ? 176 ASP A CB  1 
ATOM   1288 C CG  . ASP A 1 175 ? -13.72732 -44.58760 18.51216 1.000 47.42876 ? 176 ASP A CG  1 
ATOM   1289 O OD1 . ASP A 1 175 ? -14.67880 -45.34833 18.25568 1.000 48.12177 ? 176 ASP A OD1 1 
ATOM   1290 O OD2 . ASP A 1 175 ? -13.60464 -44.02062 19.62533 1.000 46.13714 ? 176 ASP A OD2 1 
ATOM   1291 N N   . LEU A 1 176 ? -12.99135 -46.82431 15.95601 1.000 41.27846 ? 177 LEU A N   1 
ATOM   1292 C CA  . LEU A 1 176 ? -13.28031 -48.17075 15.50323 1.000 44.85080 ? 177 LEU A CA  1 
ATOM   1293 C C   . LEU A 1 176 ? -14.06794 -48.94846 16.54714 1.000 47.36249 ? 177 LEU A C   1 
ATOM   1294 O O   . LEU A 1 176 ? -14.32991 -50.14028 16.36271 1.000 47.13597 ? 177 LEU A O   1 
ATOM   1295 C CB  . LEU A 1 176 ? -11.97718 -48.89300 15.11621 1.000 40.22504 ? 177 LEU A CB  1 
ATOM   1296 C CG  . LEU A 1 176 ? -11.63343 -48.83223 13.61775 1.000 44.46110 ? 177 LEU A CG  1 
ATOM   1297 C CD1 . LEU A 1 176 ? -12.62428 -49.63986 12.79759 1.000 48.01377 ? 177 LEU A CD1 1 
ATOM   1298 C CD2 . LEU A 1 176 ? -11.58084 -47.40381 13.07540 1.000 40.33238 ? 177 LEU A CD2 1 
ATOM   1299 N N   . GLU A 1 177 ? -14.45806 -48.28827 17.63171 1.000 51.22149 ? 178 GLU A N   1 
ATOM   1300 C CA  . GLU A 1 177 ? -15.53244 -48.76709 18.48975 1.000 50.15495 ? 178 GLU A CA  1 
ATOM   1301 C C   . GLU A 1 177 ? -16.84927 -48.06691 18.21543 1.000 45.48804 ? 178 GLU A C   1 
ATOM   1302 O O   . GLU A 1 177 ? -17.81085 -48.29250 18.94615 1.000 53.55568 ? 178 GLU A O   1 
ATOM   1303 C CB  . GLU A 1 177 ? -15.15054 -48.60453 19.95955 1.000 51.32195 ? 178 GLU A CB  1 
ATOM   1304 C CG  . GLU A 1 177 ? -14.06973 -49.58116 20.36951 1.000 58.99709 ? 178 GLU A CG  1 
ATOM   1305 C CD  . GLU A 1 177 ? -13.36527 -49.18836 21.64845 1.000 72.75893 ? 178 GLU A CD  1 
ATOM   1306 O OE1 . GLU A 1 177 ? -12.30551 -49.79332 21.93748 1.000 84.67255 ? 178 GLU A OE1 1 
ATOM   1307 O OE2 . GLU A 1 177 ? -13.85902 -48.28568 22.36246 1.000 75.84448 ? 178 GLU A OE2 1 
ATOM   1308 N N   . GLY A 1 178 ? -16.91648 -47.22012 17.19135 1.000 46.59403 ? 179 GLY A N   1 
ATOM   1309 C CA  . GLY A 1 178 ? -18.16409 -46.61837 16.75763 1.000 41.56484 ? 179 GLY A CA  1 
ATOM   1310 C C   . GLY A 1 178 ? -18.56396 -45.34326 17.46694 1.000 44.12788 ? 179 GLY A C   1 
ATOM   1311 O O   . GLY A 1 178 ? -19.65318 -44.81868 17.19644 1.000 43.29586 ? 179 GLY A O   1 
ATOM   1312 N N   . LYS A 1 179 ? -17.73765 -44.82072 18.36647 1.000 44.54309 ? 180 LYS A N   1 
ATOM   1313 C CA  . LYS A 1 179 ? -18.06225 -43.55350 19.00496 1.000 40.86762 ? 180 LYS A CA  1 
ATOM   1314 C C   . LYS A 1 179 ? -17.61372 -42.39823 18.12155 1.000 45.20628 ? 180 LYS A C   1 
ATOM   1315 O O   . LYS A 1 179 ? -16.44618 -42.33265 17.71217 1.000 45.97506 ? 180 LYS A O   1 
ATOM   1316 C CB  . LYS A 1 179 ? -17.40680 -43.45643 20.37508 1.000 45.03053 ? 180 LYS A CB  1 
ATOM   1317 C CG  . LYS A 1 179 ? -17.88206 -42.24349 21.13816 1.000 54.64356 ? 180 LYS A CG  1 
ATOM   1318 C CD  . LYS A 1 179 ? -17.40775 -42.23039 22.57893 1.000 59.65919 ? 180 LYS A CD  1 
ATOM   1319 C CE  . LYS A 1 179 ? -17.88886 -40.96128 23.27969 1.000 63.45339 ? 180 LYS A CE  1 
ATOM   1320 N NZ  . LYS A 1 179 ? -16.75455 -40.27342 23.95739 1.000 69.25585 ? 180 LYS A NZ  1 
ATOM   1321 N N   . PHE A 1 180 ? -18.53994 -41.49230 17.82281 1.000 43.11243 ? 181 PHE A N   1 
ATOM   1322 C CA  . PHE A 1 180 ? -18.24261 -40.36718 16.94401 1.000 42.34512 ? 181 PHE A CA  1 
ATOM   1323 C C   . PHE A 1 180 ? -17.16683 -39.46504 17.54121 1.000 44.25039 ? 181 PHE A C   1 
ATOM   1324 O O   . PHE A 1 180 ? -17.05611 -39.32222 18.75971 1.000 45.30155 ? 181 PHE A O   1 
ATOM   1325 C CB  . PHE A 1 180 ? -19.49878 -39.53661 16.68624 1.000 39.36440 ? 181 PHE A CB  1 
ATOM   1326 C CG  . PHE A 1 180 ? -20.19344 -39.88319 15.40724 1.000 45.61859 ? 181 PHE A CG  1 
ATOM   1327 C CD1 . PHE A 1 180 ? -19.86360 -39.22823 14.23010 1.000 43.23761 ? 181 PHE A CD1 1 
ATOM   1328 C CD2 . PHE A 1 180 ? -21.17730 -40.88890 15.37702 1.000 41.88654 ? 181 PHE A CD2 1 
ATOM   1329 C CE1 . PHE A 1 180 ? -20.49740 -39.56296 13.03303 1.000 47.55637 ? 181 PHE A CE1 1 
ATOM   1330 C CE2 . PHE A 1 180 ? -21.80425 -41.22353 14.19845 1.000 41.45646 ? 181 PHE A CE2 1 
ATOM   1331 C CZ  . PHE A 1 180 ? -21.47559 -40.55524 13.01813 1.000 44.76252 ? 181 PHE A CZ  1 
ATOM   1332 N N   . TYR A 1 181 ? -16.35573 -38.86474 16.66148 1.000 38.33691 ? 182 TYR A N   1 
ATOM   1333 C CA  . TYR A 1 181 ? -15.59684 -37.67797 17.02709 1.000 36.72006 ? 182 TYR A CA  1 
ATOM   1334 C C   . TYR A 1 181 ? -16.52124 -36.46257 16.92946 1.000 38.31912 ? 182 TYR A C   1 
ATOM   1335 O O   . TYR A 1 181 ? -17.14639 -36.22766 15.89076 1.000 40.61407 ? 182 TYR A O   1 
ATOM   1336 C CB  . TYR A 1 181 ? -14.35699 -37.50662 16.11251 1.000 39.02778 ? 182 TYR A CB  1 
ATOM   1337 C CG  . TYR A 1 181 ? -13.28920 -38.59390 16.26189 1.000 36.44102 ? 182 TYR A CG  1 
ATOM   1338 C CD1 . TYR A 1 181 ? -12.35006 -38.54576 17.29474 1.000 35.47868 ? 182 TYR A CD1 1 
ATOM   1339 C CD2 . TYR A 1 181 ? -13.22916 -39.66944 15.37496 1.000 37.00240 ? 182 TYR A CD2 1 
ATOM   1340 C CE1 . TYR A 1 181 ? -11.38556 -39.53323 17.44136 1.000 37.34213 ? 182 TYR A CE1 1 
ATOM   1341 C CE2 . TYR A 1 181 ? -12.26856 -40.67058 15.51105 1.000 34.74226 ? 182 TYR A CE2 1 
ATOM   1342 C CZ  . TYR A 1 181 ? -11.34697 -40.59629 16.54717 1.000 40.61129 ? 182 TYR A CZ  1 
ATOM   1343 O OH  . TYR A 1 181 ? -10.38633 -41.58238 16.69400 1.000 38.42198 ? 182 TYR A OH  1 
ATOM   1344 N N   . GLY A 1 182 ? -16.61812 -35.68977 18.00406 1.000 38.51891 ? 183 GLY A N   1 
ATOM   1345 C CA  . GLY A 1 182 ? -17.51375 -34.55428 18.01621 1.000 39.04877 ? 183 GLY A CA  1 
ATOM   1346 C C   . GLY A 1 182 ? -18.94375 -34.92508 18.38688 1.000 48.80518 ? 183 GLY A C   1 
ATOM   1347 O O   . GLY A 1 182 ? -19.24375 -36.08243 18.69872 1.000 46.75129 ? 183 GLY A O   1 
ATOM   1348 N N   . PRO A 1 183 ? -19.86485 -33.92955 18.34882 1.000 43.41410 ? 184 PRO A N   1 
ATOM   1349 C CA  . PRO A 1 183 ? -21.26622 -34.18567 18.71454 1.000 46.32286 ? 184 PRO A CA  1 
ATOM   1350 C C   . PRO A 1 183 ? -22.12611 -34.52864 17.50962 1.000 50.90085 ? 184 PRO A C   1 
ATOM   1351 O O   . PRO A 1 183 ? -23.27288 -34.08200 17.41856 1.000 54.17803 ? 184 PRO A O   1 
ATOM   1352 C CB  . PRO A 1 183 ? -21.71242 -32.84927 19.33307 1.000 40.66762 ? 184 PRO A CB  1 
ATOM   1353 C CG  . PRO A 1 183 ? -20.95765 -31.82780 18.52694 1.000 49.96433 ? 184 PRO A CG  1 
ATOM   1354 C CD  . PRO A 1 183 ? -19.61238 -32.49398 18.12699 1.000 42.37974 ? 184 PRO A CD  1 
ATOM   1355 N N   . PHE A 1 184 ? -21.59512 -35.29603 16.57115 1.000 48.43147 ? 185 PHE A N   1 
ATOM   1356 C CA  . PHE A 1 184 ? -22.34329 -35.58781 15.36069 1.000 48.38478 ? 185 PHE A CA  1 
ATOM   1357 C C   . PHE A 1 184 ? -23.11183 -36.90111 15.50168 1.000 49.36092 ? 185 PHE A C   1 
ATOM   1358 O O   . PHE A 1 184 ? -22.80140 -37.76072 16.33629 1.000 47.49104 ? 185 PHE A O   1 
ATOM   1359 C CB  . PHE A 1 184 ? -21.39874 -35.60950 14.14758 1.000 47.82947 ? 185 PHE A CB  1 
ATOM   1360 C CG  . PHE A 1 184 ? -20.58751 -34.36497 14.03410 1.000 46.32253 ? 185 PHE A CG  1 
ATOM   1361 C CD1 . PHE A 1 184 ? -21.18657 -33.16958 13.67137 1.000 51.44980 ? 185 PHE A CD1 1 
ATOM   1362 C CD2 . PHE A 1 184 ? -19.25888 -34.35761 14.39170 1.000 39.42940 ? 185 PHE A CD2 1 
ATOM   1363 C CE1 . PHE A 1 184 ? -20.45161 -31.98906 13.61836 1.000 48.83806 ? 185 PHE A CE1 1 
ATOM   1364 C CE2 . PHE A 1 184 ? -18.53360 -33.18799 14.34544 1.000 47.28757 ? 185 PHE A CE2 1 
ATOM   1365 C CZ  . PHE A 1 184 ? -19.13363 -32.00143 13.95805 1.000 48.48067 ? 185 PHE A CZ  1 
ATOM   1366 N N   . VAL A 1 185 ? -24.13268 -37.04121 14.67114 1.000 42.67136 ? 186 VAL A N   1 
ATOM   1367 C CA  . VAL A 1 185 ? -25.01289 -38.19783 14.72104 1.000 50.80990 ? 186 VAL A CA  1 
ATOM   1368 C C   . VAL A 1 185 ? -25.17288 -38.72359 13.30771 1.000 48.28828 ? 186 VAL A C   1 
ATOM   1369 O O   . VAL A 1 185 ? -25.10210 -37.95821 12.34180 1.000 47.37783 ? 186 VAL A O   1 
ATOM   1370 C CB  . VAL A 1 185 ? -26.38782 -37.83718 15.34543 1.000 47.19099 ? 186 VAL A CB  1 
ATOM   1371 C CG1 . VAL A 1 185 ? -26.19504 -37.41485 16.77663 1.000 43.06117 ? 186 VAL A CG1 1 
ATOM   1372 C CG2 . VAL A 1 185 ? -27.04439 -36.72060 14.55913 1.000 45.80601 ? 186 VAL A CG2 1 
ATOM   1373 N N   . ASP A 1 186 ? -25.40079 -40.03455 13.18374 1.000 45.96742 ? 187 ASP A N   1 
ATOM   1374 C CA  . ASP A 1 186 ? -25.50393 -40.64886 11.85714 1.000 50.15575 ? 187 ASP A CA  1 
ATOM   1375 C C   . ASP A 1 186 ? -26.96237 -40.67584 11.38877 1.000 48.97319 ? 187 ASP A C   1 
ATOM   1376 O O   . ASP A 1 186 ? -27.56868 -41.71664 11.14205 1.000 47.47564 ? 187 ASP A O   1 
ATOM   1377 C CB  . ASP A 1 186 ? -24.86490 -42.03933 11.84041 1.000 45.50344 ? 187 ASP A CB  1 
ATOM   1378 C CG  . ASP A 1 186 ? -25.28805 -42.89665 13.01421 1.000 49.75047 ? 187 ASP A CG  1 
ATOM   1379 O OD1 . ASP A 1 186 ? -25.72715 -42.32063 14.03238 1.000 52.25335 ? 187 ASP A OD1 1 
ATOM   1380 O OD2 . ASP A 1 186 ? -25.17345 -44.14233 12.92641 1.000 48.61464 ? 187 ASP A OD2 1 
ATOM   1381 N N   . ARG A 1 187 ? -27.50673 -39.47175 11.25967 1.000 46.27462 ? 188 ARG A N   1 
ATOM   1382 C CA  . ARG A 1 187 ? -28.78982 -39.21250 10.62404 1.000 55.32873 ? 188 ARG A CA  1 
ATOM   1383 C C   . ARG A 1 187 ? -28.66231 -37.92060 9.83545  1.000 58.80266 ? 188 ARG A C   1 
ATOM   1384 O O   . ARG A 1 187 ? -27.70448 -37.16497 10.00223 1.000 57.32649 ? 188 ARG A O   1 
ATOM   1385 C CB  . ARG A 1 187 ? -29.94350 -39.06786 11.63704 1.000 55.54435 ? 188 ARG A CB  1 
ATOM   1386 C CG  . ARG A 1 187 ? -29.74082 -39.78554 12.95808 1.000 61.76513 ? 188 ARG A CG  1 
ATOM   1387 C CD  . ARG A 1 187 ? -30.99494 -39.71812 13.83900 1.000 56.24828 ? 188 ARG A CD  1 
ATOM   1388 N NE  . ARG A 1 187 ? -31.17161 -38.37411 14.37081 1.000 61.48577 ? 188 ARG A NE  1 
ATOM   1389 C CZ  . ARG A 1 187 ? -30.73251 -37.98584 15.56286 1.000 63.91543 ? 188 ARG A CZ  1 
ATOM   1390 N NH1 . ARG A 1 187 ? -30.93839 -36.74065 15.97838 1.000 69.63187 ? 188 ARG A NH1 1 
ATOM   1391 N NH2 . ARG A 1 187 ? -30.08329 -38.84530 16.33870 1.000 61.37562 ? 188 ARG A NH2 1 
ATOM   1392 N N   . GLN A 1 188 ? -29.64482 -37.65326 8.98195  1.000 61.14389 ? 189 GLN A N   1 
ATOM   1393 C CA  . GLN A 1 188 ? -29.77352 -36.34421 8.35569  1.000 61.94077 ? 189 GLN A CA  1 
ATOM   1394 C C   . GLN A 1 188 ? -30.48200 -35.41914 9.33784  1.000 65.69160 ? 189 GLN A C   1 
ATOM   1395 O O   . GLN A 1 188 ? -31.66755 -35.60039 9.63098  1.000 68.00926 ? 189 GLN A O   1 
ATOM   1396 C CB  . GLN A 1 188 ? -30.53236 -36.43588 7.03868  1.000 67.48361 ? 189 GLN A CB  1 
ATOM   1397 C CG  . GLN A 1 188 ? -30.59984 -35.12692 6.28412  1.000 71.44620 ? 189 GLN A CG  1 
ATOM   1398 C CD  . GLN A 1 188 ? -31.35812 -35.25375 4.97635  1.000 78.83144 ? 189 GLN A CD  1 
ATOM   1399 O OE1 . GLN A 1 188 ? -31.97128 -36.28597 4.69854  1.000 79.63280 ? 189 GLN A OE1 1 
ATOM   1400 N NE2 . GLN A 1 188 ? -31.31278 -34.20493 4.16043  1.000 81.21454 ? 189 GLN A NE2 1 
ATOM   1401 N N   . THR A 1 189 ? -29.73993 -34.45977 9.88093  1.000 64.86654 ? 190 THR A N   1 
ATOM   1402 C CA  . THR A 1 189 ? -30.28790 -33.41976 10.73848 1.000 62.07552 ? 190 THR A CA  1 
ATOM   1403 C C   . THR A 1 189 ? -29.74808 -32.07167 10.28450 1.000 66.74958 ? 190 THR A C   1 
ATOM   1404 O O   . THR A 1 189 ? -29.15085 -31.96581 9.20718  1.000 69.59627 ? 190 THR A O   1 
ATOM   1405 C CB  . THR A 1 189 ? -29.92546 -33.65893 12.20923 1.000 64.45350 ? 190 THR A CB  1 
ATOM   1406 O OG1 . THR A 1 189 ? -28.54546 -33.33738 12.42719 1.000 66.13640 ? 190 THR A OG1 1 
ATOM   1407 C CG2 . THR A 1 189 ? -30.16727 -35.09865 12.62073 1.000 63.71419 ? 190 THR A CG2 1 
ATOM   1408 N N   . ALA A 1 190 ? -29.94452 -31.03605 11.09493 1.000 66.87860 ? 191 ALA A N   1 
ATOM   1409 C CA  . ALA A 1 190 ? -29.30343 -29.74405 10.86281 1.000 73.50465 ? 191 ALA A CA  1 
ATOM   1410 C C   . ALA A 1 190 ? -28.17540 -29.62310 11.88382 1.000 74.45328 ? 191 ALA A C   1 
ATOM   1411 O O   . ALA A 1 190 ? -28.28517 -28.95061 12.91055 1.000 80.02534 ? 191 ALA A O   1 
ATOM   1412 C CB  . ALA A 1 190 ? -30.30847 -28.59799 10.96816 1.000 71.79707 ? 191 ALA A CB  1 
ATOM   1413 N N   . GLN A 1 191 ? -27.08870 -30.33040 11.61103 1.000 68.93175 ? 192 GLN A N   1 
ATOM   1414 C CA  . GLN A 1 191 ? -25.89808 -30.27139 12.43908 1.000 63.30682 ? 192 GLN A CA  1 
ATOM   1415 C C   . GLN A 1 191 ? -24.81069 -29.59895 11.62521 1.000 62.74690 ? 192 GLN A C   1 
ATOM   1416 O O   . GLN A 1 191 ? -24.69893 -29.82981 10.41713 1.000 66.92356 ? 192 GLN A O   1 
ATOM   1417 C CB  . GLN A 1 191 ? -25.44988 -31.66736 12.90353 1.000 57.73872 ? 192 GLN A CB  1 
ATOM   1418 C CG  . GLN A 1 191 ? -25.31133 -32.69751 11.78864 1.000 55.44855 ? 192 GLN A CG  1 
ATOM   1419 C CD  . GLN A 1 191 ? -25.01407 -34.11298 12.30699 1.000 55.60858 ? 192 GLN A CD  1 
ATOM   1420 O OE1 . GLN A 1 191 ? -24.65433 -34.30806 13.47109 1.000 49.68328 ? 192 GLN A OE1 1 
ATOM   1421 N NE2 . GLN A 1 191 ? -25.18268 -35.10759 11.43727 1.000 55.45156 ? 192 GLN A NE2 1 
ATOM   1422 N N   . ALA A 1 192 ? -24.03825 -28.73573 12.27148 1.000 61.73735 ? 193 ALA A N   1 
ATOM   1423 C CA  . ALA A 1 192 ? -22.92589 -28.07821 11.60932 1.000 57.40846 ? 193 ALA A CA  1 
ATOM   1424 C C   . ALA A 1 192 ? -21.67156 -28.22795 12.45070 1.000 49.99844 ? 193 ALA A C   1 
ATOM   1425 O O   . ALA A 1 192 ? -21.73220 -28.35758 13.67446 1.000 50.89441 ? 193 ALA A O   1 
ATOM   1426 C CB  . ALA A 1 192 ? -23.21053 -26.59835 11.36224 1.000 52.81540 ? 193 ALA A CB  1 
ATOM   1427 N N   . ALA A 1 193 ? -20.53288 -28.22639 11.77620 1.000 54.95738 ? 194 ALA A N   1 
ATOM   1428 C CA  . ALA A 1 193 ? -19.26795 -28.05347 12.47173 1.000 53.59386 ? 194 ALA A CA  1 
ATOM   1429 C C   . ALA A 1 193 ? -19.29905 -26.74925 13.25539 1.000 54.64455 ? 194 ALA A C   1 
ATOM   1430 O O   . ALA A 1 193 ? -19.72695 -25.71167 12.73964 1.000 57.43848 ? 194 ALA A O   1 
ATOM   1431 C CB  . ALA A 1 193 ? -18.11401 -28.04109 11.46735 1.000 47.68327 ? 194 ALA A CB  1 
ATOM   1432 N N   . GLY A 1 194 ? -18.86655 -26.79841 14.50539 1.000 53.37669 ? 195 GLY A N   1 
ATOM   1433 C CA  . GLY A 1 194 ? -18.63676 -25.56803 15.22854 1.000 52.51873 ? 195 GLY A CA  1 
ATOM   1434 C C   . GLY A 1 194 ? -17.47050 -24.80677 14.62661 1.000 54.37061 ? 195 GLY A C   1 
ATOM   1435 O O   . GLY A 1 194 ? -16.72385 -25.31940 13.78581 1.000 54.86311 ? 195 GLY A O   1 
ATOM   1436 N N   . THR A 1 195 ? -17.30785 -23.55803 15.06870 1.000 53.16125 ? 196 THR A N   1 
ATOM   1437 C CA  . THR A 1 195 ? -16.18573 -22.74515 14.60485 1.000 51.25742 ? 196 THR A CA  1 
ATOM   1438 C C   . THR A 1 195 ? -14.86716 -23.47907 14.81669 1.000 48.19818 ? 196 THR A C   1 
ATOM   1439 O O   . THR A 1 195 ? -14.63242 -24.05778 15.87818 1.000 53.25651 ? 196 THR A O   1 
ATOM   1440 C CB  . THR A 1 195 ? -16.15305 -21.41178 15.34961 1.000 51.53873 ? 196 THR A CB  1 
ATOM   1441 O OG1 . THR A 1 195 ? -17.45681 -20.82382 15.34858 1.000 60.78791 ? 196 THR A OG1 1 
ATOM   1442 C CG2 . THR A 1 195 ? -15.18493 -20.46040 14.67184 1.000 54.77873 ? 196 THR A CG2 1 
ATOM   1443 N N   . ASP A 1 196 ? -14.00787 -23.46372 13.80453 1.000 50.07113 ? 197 ASP A N   1 
ATOM   1444 C CA  . ASP A 1 196 ? -12.70418 -24.09552 13.93932 1.000 47.79471 ? 197 ASP A CA  1 
ATOM   1445 C C   . ASP A 1 196 ? -11.67624 -23.08624 14.46185 1.000 55.50418 ? 197 ASP A C   1 
ATOM   1446 O O   . ASP A 1 196 ? -11.94785 -21.88821 14.58171 1.000 53.57956 ? 197 ASP A O   1 
ATOM   1447 C CB  . ASP A 1 196 ? -12.24888 -24.68723 12.60437 1.000 49.36608 ? 197 ASP A CB  1 
ATOM   1448 C CG  . ASP A 1 196 ? -11.19539 -25.77125 12.77863 1.000 50.89515 ? 197 ASP A CG  1 
ATOM   1449 O OD1 . ASP A 1 196 ? -11.15415 -26.39120 13.86901 1.000 51.05436 ? 197 ASP A OD1 1 
ATOM   1450 O OD2 . ASP A 1 196 ? -10.41591 -26.00283 11.83353 1.000 51.43331 ? 197 ASP A OD2 1 
ATOM   1451 N N   . THR A 1 197 ? -10.49007 -23.59572 14.81323 1.000 51.81486 ? 198 THR A N   1 
ATOM   1452 C CA  . THR A 1 197 ? -9.36630  -22.77133 15.24744 1.000 53.61023 ? 198 THR A CA  1 
ATOM   1453 C C   . THR A 1 197 ? -8.07558  -23.34385 14.65666 1.000 49.39236 ? 198 THR A C   1 
ATOM   1454 O O   . THR A 1 197 ? -8.05528  -24.43453 14.07759 1.000 48.74975 ? 198 THR A O   1 
ATOM   1455 C CB  . THR A 1 197 ? -9.27655  -22.67495 16.79092 1.000 52.90003 ? 198 THR A CB  1 
ATOM   1456 O OG1 . THR A 1 197 ? -8.74709  -23.89353 17.32470 1.000 57.79457 ? 198 THR A OG1 1 
ATOM   1457 C CG2 . THR A 1 197 ? -10.63577 -22.43892 17.41325 1.000 48.65648 ? 198 THR A CG2 1 
ATOM   1458 N N   . THR A 1 198 ? -6.98587  -22.59813 14.79533 1.000 46.89626 ? 199 THR A N   1 
ATOM   1459 C CA  . THR A 1 198 ? -5.70784  -23.02113 14.23799 1.000 45.94578 ? 199 THR A CA  1 
ATOM   1460 C C   . THR A 1 198 ? -4.91328  -23.77195 15.30268 1.000 47.06019 ? 199 THR A C   1 
ATOM   1461 O O   . THR A 1 198 ? -4.88448  -23.37147 16.47227 1.000 50.82264 ? 199 THR A O   1 
ATOM   1462 C CB  . THR A 1 198 ? -4.93900  -21.80732 13.70859 1.000 49.48400 ? 199 THR A CB  1 
ATOM   1463 O OG1 . THR A 1 198 ? -5.72269  -21.17396 12.68737 1.000 53.06098 ? 199 THR A OG1 1 
ATOM   1464 C CG2 . THR A 1 198 ? -3.56333  -22.19512 13.12627 1.000 45.86564 ? 199 THR A CG2 1 
ATOM   1465 N N   . ILE A 1 199 ? -4.29127  -24.88122 14.89808 1.000 44.60968 ? 200 ILE A N   1 
ATOM   1466 C CA  . ILE A 1 199 ? -3.58191  -25.74775 15.83486 1.000 42.47583 ? 200 ILE A CA  1 
ATOM   1467 C C   . ILE A 1 199 ? -2.18180  -25.18988 16.10875 1.000 44.09464 ? 200 ILE A C   1 
ATOM   1468 O O   . ILE A 1 199 ? -1.20801  -25.50980 15.41037 1.000 43.80147 ? 200 ILE A O   1 
ATOM   1469 C CB  . ILE A 1 199 ? -3.52425  -27.19237 15.31097 1.000 41.61623 ? 200 ILE A CB  1 
ATOM   1470 C CG1 . ILE A 1 199 ? -4.92422  -27.66932 14.87549 1.000 44.46052 ? 200 ILE A CG1 1 
ATOM   1471 C CG2 . ILE A 1 199 ? -2.92233  -28.11545 16.36295 1.000 37.76388 ? 200 ILE A CG2 1 
ATOM   1472 C CD1 . ILE A 1 199 ? -4.90866  -28.96270 14.03362 1.000 40.87070 ? 200 ILE A CD1 1 
ATOM   1473 N N   . THR A 1 200 ? -2.08764  -24.37530 17.15851 1.000 43.25131 ? 201 THR A N   1 
ATOM   1474 C CA  . THR A 1 200 ? -0.85497  -23.69398 17.53551 1.000 41.32017 ? 201 THR A CA  1 
ATOM   1475 C C   . THR A 1 200 ? 0.31442   -24.65718 17.70768 1.000 44.22442 ? 201 THR A C   1 
ATOM   1476 O O   . THR A 1 200 ? 1.42542   -24.39328 17.23095 1.000 41.64160 ? 201 THR A O   1 
ATOM   1477 C CB  . THR A 1 200 ? -1.10473  -22.90233 18.81611 1.000 40.14673 ? 201 THR A CB  1 
ATOM   1478 O OG1 . THR A 1 200 ? -2.27829  -22.09903 18.63238 1.000 42.89246 ? 201 THR A OG1 1 
ATOM   1479 C CG2 . THR A 1 200 ? 0.07746   -21.99002 19.15184 1.000 43.06846 ? 201 THR A CG2 1 
ATOM   1480 N N   . LEU A 1 201 ? 0.09434   -25.77540 18.39498 1.000 40.11602 ? 202 LEU A N   1 
ATOM   1481 C CA  . LEU A 1 201 ? 1.16554   -26.75320 18.51118 1.000 43.29755 ? 202 LEU A CA  1 
ATOM   1482 C C   . LEU A 1 201 ? 1.74071   -27.10456 17.13991 1.000 50.61200 ? 202 LEU A C   1 
ATOM   1483 O O   . LEU A 1 201 ? 2.96154   -27.24853 16.97793 1.000 46.22431 ? 202 LEU A O   1 
ATOM   1484 C CB  . LEU A 1 201 ? 0.67818   -28.01447 19.20526 1.000 40.57242 ? 202 LEU A CB  1 
ATOM   1485 C CG  . LEU A 1 201 ? 1.80070   -29.04526 19.41068 1.000 45.13785 ? 202 LEU A CG  1 
ATOM   1486 C CD1 . LEU A 1 201 ? 2.97766   -28.41257 20.12091 1.000 43.94372 ? 202 LEU A CD1 1 
ATOM   1487 C CD2 . LEU A 1 201 ? 1.32674   -30.24001 20.20468 1.000 44.55090 ? 202 LEU A CD2 1 
ATOM   1488 N N   . ASN A 1 202 ? 0.87910   -27.22122 16.13087 1.000 49.09312 ? 203 ASN A N   1 
ATOM   1489 C CA  . ASN A 1 202 ? 1.36168   -27.71720 14.84913 1.000 47.33038 ? 203 ASN A CA  1 
ATOM   1490 C C   . ASN A 1 202 ? 2.09310   -26.63123 14.05573 1.000 44.49605 ? 203 ASN A C   1 
ATOM   1491 O O   . ASN A 1 202 ? 3.05592   -26.92582 13.34101 1.000 41.48743 ? 203 ASN A O   1 
ATOM   1492 C CB  . ASN A 1 202 ? 0.18714   -28.29409 14.06060 1.000 46.39431 ? 203 ASN A CB  1 
ATOM   1493 C CG  . ASN A 1 202 ? -0.21691  -29.69029 14.54218 1.000 47.67185 ? 203 ASN A CG  1 
ATOM   1494 O OD1 . ASN A 1 202 ? 0.37072   -30.23746 15.47284 1.000 46.93983 ? 203 ASN A OD1 1 
ATOM   1495 N ND2 . ASN A 1 202 ? -1.19695  -30.27681 13.87995 1.000 41.70735 ? 203 ASN A ND2 1 
ATOM   1496 N N   . VAL A 1 203 ? 1.62392   -25.38607 14.14136 1.000 43.19451 ? 204 VAL A N   1 
ATOM   1497 C CA  . VAL A 1 203 ? 2.31990   -24.27777 13.50190 1.000 46.98356 ? 204 VAL A CA  1 
ATOM   1498 C C   . VAL A 1 203 ? 3.72581   -24.15902 14.06778 1.000 49.76047 ? 204 VAL A C   1 
ATOM   1499 O O   . VAL A 1 203 ? 4.71707   -24.08528 13.32773 1.000 47.29674 ? 204 VAL A O   1 
ATOM   1500 C CB  . VAL A 1 203 ? 1.53053   -22.97331 13.69285 1.000 50.51517 ? 204 VAL A CB  1 
ATOM   1501 C CG1 . VAL A 1 203 ? 2.39738   -21.77484 13.34072 1.000 50.52880 ? 204 VAL A CG1 1 
ATOM   1502 C CG2 . VAL A 1 203 ? 0.24589   -22.99710 12.87902 1.000 44.63429 ? 204 VAL A CG2 1 
ATOM   1503 N N   . LEU A 1 204 ? 3.83606   -24.18067 15.39584 1.000 44.83572 ? 205 LEU A N   1 
ATOM   1504 C CA  . LEU A 1 204 ? 5.14881   -24.07413 16.00734 1.000 45.70521 ? 205 LEU A CA  1 
ATOM   1505 C C   . LEU A 1 204 ? 6.04333   -25.23050 15.58912 1.000 49.97008 ? 205 LEU A C   1 
ATOM   1506 O O   . LEU A 1 204 ? 7.24927   -25.04116 15.38395 1.000 46.75952 ? 205 LEU A O   1 
ATOM   1507 C CB  . LEU A 1 204 ? 5.02446   -23.99458 17.52330 1.000 41.76061 ? 205 LEU A CB  1 
ATOM   1508 C CG  . LEU A 1 204 ? 4.49278   -22.65326 18.05825 1.000 48.92297 ? 205 LEU A CG  1 
ATOM   1509 C CD1 . LEU A 1 204 ? 4.05780   -22.78988 19.51557 1.000 33.89287 ? 205 LEU A CD1 1 
ATOM   1510 C CD2 . LEU A 1 204 ? 5.53442   -21.50719 17.90018 1.000 42.82198 ? 205 LEU A CD2 1 
ATOM   1511 N N   . ALA A 1 205 ? 5.48076   -26.43735 15.45357 1.000 45.26483 ? 206 ALA A N   1 
ATOM   1512 C CA  . ALA A 1 205 ? 6.29664   -27.54877 14.97999 1.000 43.59294 ? 206 ALA A CA  1 
ATOM   1513 C C   . ALA A 1 205 ? 6.79785   -27.28232 13.57096 1.000 51.31708 ? 206 ALA A C   1 
ATOM   1514 O O   . ALA A 1 205 ? 7.93195   -27.63227 13.22706 1.000 48.37090 ? 206 ALA A O   1 
ATOM   1515 C CB  . ALA A 1 205 ? 5.52093   -28.85683 15.02141 1.000 46.93061 ? 206 ALA A CB  1 
ATOM   1516 N N   . TRP A 1 206 ? 5.96568   -26.64486 12.75029 1.000 50.21144 ? 207 TRP A N   1 
ATOM   1517 C CA  . TRP A 1 206 ? 6.31933   -26.38543 11.36539 1.000 50.58374 ? 207 TRP A CA  1 
ATOM   1518 C C   . TRP A 1 206 ? 7.44086   -25.35465 11.26676 1.000 55.07605 ? 207 TRP A C   1 
ATOM   1519 O O   . TRP A 1 206 ? 8.42786   -25.56112 10.54599 1.000 56.94142 ? 207 TRP A O   1 
ATOM   1520 C CB  . TRP A 1 206 ? 5.08151   -25.91353 10.63573 1.000 48.43926 ? 207 TRP A CB  1 
ATOM   1521 C CG  . TRP A 1 206 ? 5.20976   -25.72863 9.19600  1.000 55.91655 ? 207 TRP A CG  1 
ATOM   1522 C CD1 . TRP A 1 206 ? 5.51371   -26.67683 8.26432  1.000 59.53839 ? 207 TRP A CD1 1 
ATOM   1523 C CD2 . TRP A 1 206 ? 4.95858   -24.52437 8.48234  1.000 59.65934 ? 207 TRP A CD2 1 
ATOM   1524 N NE1 . TRP A 1 206 ? 5.48244   -26.12611 7.00916  1.000 61.40950 ? 207 TRP A NE1 1 
ATOM   1525 C CE2 . TRP A 1 206 ? 5.14091   -24.80301 7.11717  1.000 61.58353 ? 207 TRP A CE2 1 
ATOM   1526 C CE3 . TRP A 1 206 ? 4.59808   -23.23087 8.86694  1.000 62.63127 ? 207 TRP A CE3 1 
ATOM   1527 C CZ2 . TRP A 1 206 ? 4.98614   -23.83364 6.13329  1.000 65.92627 ? 207 TRP A CZ2 1 
ATOM   1528 C CZ3 . TRP A 1 206 ? 4.44155   -22.27042 7.89094  1.000 64.97096 ? 207 TRP A CZ3 1 
ATOM   1529 C CH2 . TRP A 1 206 ? 4.63652   -22.57766 6.53791  1.000 68.08016 ? 207 TRP A CH2 1 
ATOM   1530 N N   . LEU A 1 207 ? 7.30172   -24.23672 11.98836 1.000 50.81753 ? 208 LEU A N   1 
ATOM   1531 C CA  . LEU A 1 207 ? 8.38577   -23.26422 12.08832 1.000 52.60874 ? 208 LEU A CA  1 
ATOM   1532 C C   . LEU A 1 207 ? 9.69500   -23.92284 12.50745 1.000 53.19480 ? 208 LEU A C   1 
ATOM   1533 O O   . LEU A 1 207 ? 10.75097  -23.61551 11.95100 1.000 56.57802 ? 208 LEU A O   1 
ATOM   1534 C CB  . LEU A 1 207 ? 7.99912   -22.15328 13.05816 1.000 47.96212 ? 208 LEU A CB  1 
ATOM   1535 C CG  . LEU A 1 207 ? 6.75209   -21.39875 12.59059 1.000 49.27557 ? 208 LEU A CG  1 
ATOM   1536 C CD1 . LEU A 1 207 ? 6.33464   -20.31569 13.58639 1.000 46.07904 ? 208 LEU A CD1 1 
ATOM   1537 C CD2 . LEU A 1 207 ? 6.94659   -20.82112 11.20690 1.000 48.42066 ? 208 LEU A CD2 1 
ATOM   1538 N N   . TYR A 1 208 ? 9.65076   -24.85056 13.46543 1.000 50.27138 ? 209 TYR A N   1 
ATOM   1539 C CA  . TYR A 1 208 ? 10.86586  -25.58965 13.79072 1.000 52.06435 ? 209 TYR A CA  1 
ATOM   1540 C C   . TYR A 1 208 ? 11.32892  -26.45760 12.62985 1.000 60.57082 ? 209 TYR A C   1 
ATOM   1541 O O   . TYR A 1 208 ? 12.53853  -26.65089 12.45201 1.000 63.26613 ? 209 TYR A O   1 
ATOM   1542 C CB  . TYR A 1 208 ? 10.67445  -26.46534 15.01535 1.000 45.53784 ? 209 TYR A CB  1 
ATOM   1543 C CG  . TYR A 1 208 ? 10.81381  -25.75655 16.33465 1.000 54.35245 ? 209 TYR A CG  1 
ATOM   1544 C CD1 . TYR A 1 208 ? 12.05197  -25.28930 16.78446 1.000 54.40261 ? 209 TYR A CD1 1 
ATOM   1545 C CD2 . TYR A 1 208 ? 9.70264   -25.56943 17.15165 1.000 52.37695 ? 209 TYR A CD2 1 
ATOM   1546 C CE1 . TYR A 1 208 ? 12.16693  -24.65056 18.00893 1.000 54.45084 ? 209 TYR A CE1 1 
ATOM   1547 C CE2 . TYR A 1 208 ? 9.80554   -24.93009 18.36261 1.000 50.50350 ? 209 TYR A CE2 1 
ATOM   1548 C CZ  . TYR A 1 208 ? 11.03015  -24.47929 18.79444 1.000 53.55763 ? 209 TYR A CZ  1 
ATOM   1549 O OH  . TYR A 1 208 ? 11.10150  -23.85996 20.01310 1.000 49.15106 ? 209 TYR A OH  1 
ATOM   1550 N N   . ALA A 1 209 ? 10.39800  -27.00849 11.84763 1.000 56.69552 ? 210 ALA A N   1 
ATOM   1551 C CA  . ALA A 1 209 ? 10.79757  -27.72956 10.64573 1.000 58.57595 ? 210 ALA A CA  1 
ATOM   1552 C C   . ALA A 1 209 ? 11.49431  -26.79100 9.67491  1.000 64.17774 ? 210 ALA A C   1 
ATOM   1553 O O   . ALA A 1 209 ? 12.53717  -27.12772 9.09914  1.000 64.69062 ? 210 ALA A O   1 
ATOM   1554 C CB  . ALA A 1 209 ? 9.58505   -28.37589 9.97807  1.000 56.29687 ? 210 ALA A CB  1 
ATOM   1555 N N   . ALA A 1 210 ? 10.91963  -25.60416 9.48389  1.000 60.42464 ? 211 ALA A N   1 
ATOM   1556 C CA  . ALA A 1 210 ? 11.49031  -24.62523 8.57230  1.000 62.01123 ? 211 ALA A CA  1 
ATOM   1557 C C   . ALA A 1 210 ? 12.90676  -24.25587 8.99254  1.000 67.01401 ? 211 ALA A C   1 
ATOM   1558 O O   . ALA A 1 210 ? 13.83881  -24.29255 8.18069  1.000 68.50472 ? 211 ALA A O   1 
ATOM   1559 C CB  . ALA A 1 210 ? 10.58678  -23.39501 8.52128  1.000 60.24467 ? 211 ALA A CB  1 
ATOM   1560 N N   . VAL A 1 211 ? 13.08834  -23.93517 10.27488 1.000 65.26768 ? 212 VAL A N   1 
ATOM   1561 C CA  . VAL A 1 211 ? 14.42451  -23.67529 10.80336 1.000 67.36676 ? 212 VAL A CA  1 
ATOM   1562 C C   . VAL A 1 211 ? 15.35506  -24.84183 10.49784 1.000 69.70529 ? 212 VAL A C   1 
ATOM   1563 O O   . VAL A 1 211 ? 16.48579  -24.64838 10.03843 1.000 73.47738 ? 212 VAL A O   1 
ATOM   1564 C CB  . VAL A 1 211 ? 14.36019  -23.38682 12.31358 1.000 63.13333 ? 212 VAL A CB  1 
ATOM   1565 C CG1 . VAL A 1 211 ? 15.70886  -23.66046 12.94983 1.000 68.00898 ? 212 VAL A CG1 1 
ATOM   1566 C CG2 . VAL A 1 211 ? 13.90473  -21.95317 12.56831 1.000 57.88185 ? 212 VAL A CG2 1 
ATOM   1567 N N   . ILE A 1 212 ? 14.89506  -26.07432 10.73275 1.000 68.65128 ? 213 ILE A N   1 
ATOM   1568 C CA  . ILE A 1 212 ? 15.78674  -27.21429 10.51771 1.000 71.61181 ? 213 ILE A CA  1 
ATOM   1569 C C   . ILE A 1 212 ? 16.12860  -27.36848 9.03949  1.000 75.45127 ? 213 ILE A C   1 
ATOM   1570 O O   . ILE A 1 212 ? 17.24462  -27.78249 8.69649  1.000 80.14196 ? 213 ILE A O   1 
ATOM   1571 C CB  . ILE A 1 212 ? 15.18879  -28.51091 11.09197 1.000 73.11734 ? 213 ILE A CB  1 
ATOM   1572 C CG1 . ILE A 1 212 ? 14.96376  -28.38084 12.59643 1.000 75.08589 ? 213 ILE A CG1 1 
ATOM   1573 C CG2 . ILE A 1 212 ? 16.13307  -29.67646 10.86676 1.000 71.49817 ? 213 ILE A CG2 1 
ATOM   1574 C CD1 . ILE A 1 212 ? 14.46409  -29.65971 13.27319 1.000 68.52154 ? 213 ILE A CD1 1 
ATOM   1575 N N   . ASN A 1 213 ? 15.20482  -27.01549 8.13944  1.000 72.54702 ? 214 ASN A N   1 
ATOM   1576 C CA  . ASN A 1 213 ? 15.50469  -27.00442 6.70985  1.000 73.92318 ? 214 ASN A CA  1 
ATOM   1577 C C   . ASN A 1 213 ? 16.15072  -25.70053 6.23915  1.000 74.49003 ? 214 ASN A C   1 
ATOM   1578 O O   . ASN A 1 213 ? 16.02384  -25.36614 5.05695  1.000 73.99036 ? 214 ASN A O   1 
ATOM   1579 C CB  . ASN A 1 213 ? 14.24113  -27.26573 5.88608  1.000 73.83840 ? 214 ASN A CB  1 
ATOM   1580 C CG  . ASN A 1 213 ? 14.04632  -28.73412 5.55932  1.000 83.70775 ? 214 ASN A CG  1 
ATOM   1581 O OD1 . ASN A 1 213 ? 14.37433  -29.18346 4.45799  1.000 85.60811 ? 214 ASN A OD1 1 
ATOM   1582 N ND2 . ASN A 1 213 ? 13.47918  -29.48737 6.50677  1.000 82.48044 ? 214 ASN A ND2 1 
ATOM   1583 N N   . GLY A 1 214 ? 16.79860  -24.94732 7.12702  1.000 70.85065 ? 215 GLY A N   1 
ATOM   1584 C CA  . GLY A 1 214 ? 17.62080  -23.82559 6.73364  1.000 71.96510 ? 215 GLY A CA  1 
ATOM   1585 C C   . GLY A 1 214 ? 16.91665  -22.50683 6.47912  1.000 76.19200 ? 215 GLY A C   1 
ATOM   1586 O O   . GLY A 1 214 ? 17.59246  -21.51719 6.16863  1.000 76.16890 ? 215 GLY A O   1 
ATOM   1587 N N   . ASP A 1 215 ? 15.59701  -22.43746 6.58323  1.000 75.32808 ? 216 ASP A N   1 
ATOM   1588 C CA  . ASP A 1 215 ? 14.91078  -21.16536 6.40889  1.000 76.87429 ? 216 ASP A CA  1 
ATOM   1589 C C   . ASP A 1 215 ? 14.71167  -20.54232 7.78424  1.000 77.60464 ? 216 ASP A C   1 
ATOM   1590 O O   . ASP A 1 215 ? 14.20187  -21.19666 8.69967  1.000 74.92119 ? 216 ASP A O   1 
ATOM   1591 C CB  . ASP A 1 215 ? 13.58220  -21.33988 5.67050  1.000 78.18792 ? 216 ASP A CB  1 
ATOM   1592 C CG  . ASP A 1 215 ? 13.10454  -20.04953 5.00056  1.000 84.94685 ? 216 ASP A CG  1 
ATOM   1593 O OD1 . ASP A 1 215 ? 13.32858  -18.94947 5.56214  1.000 78.76935 ? 216 ASP A OD1 1 
ATOM   1594 O OD2 . ASP A 1 215 ? 12.49073  -20.13696 3.91123  1.000 91.10408 ? 216 ASP A OD2 1 
ATOM   1595 N N   . ARG A 1 216 ? 15.11157  -19.27363 7.91655  1.000 76.31360 ? 217 ARG A N   1 
ATOM   1596 C CA  . ARG A 1 216 ? 15.32751  -18.66935 9.22497  1.000 66.64382 ? 217 ARG A CA  1 
ATOM   1597 C C   . ARG A 1 216 ? 14.92224  -17.19787 9.26880  1.000 62.22117 ? 217 ARG A C   1 
ATOM   1598 O O   . ARG A 1 216 ? 15.18055  -16.53160 10.28019 1.000 56.42577 ? 217 ARG A O   1 
ATOM   1599 C CB  . ARG A 1 216 ? 16.80338  -18.82830 9.58416  1.000 66.94710 ? 217 ARG A CB  1 
ATOM   1600 C CG  . ARG A 1 216 ? 17.13127  -19.10311 11.02435 1.000 65.32440 ? 217 ARG A CG  1 
ATOM   1601 C CD  . ARG A 1 216 ? 18.65713  -19.07164 11.25753 1.000 52.35542 ? 217 ARG A CD  1 
ATOM   1602 N NE  . ARG A 1 216 ? 18.95238  -18.62317 12.61723 1.000 53.64955 ? 217 ARG A NE  1 
ATOM   1603 C CZ  . ARG A 1 216 ? 19.16010  -19.43409 13.65272 1.000 59.12508 ? 217 ARG A CZ  1 
ATOM   1604 N NH1 . ARG A 1 216 ? 19.12423  -20.75444 13.49258 1.000 60.53541 ? 217 ARG A NH1 1 
ATOM   1605 N NH2 . ARG A 1 216 ? 19.41100  -18.92295 14.85225 1.000 55.19417 ? 217 ARG A NH2 1 
ATOM   1606 N N   . TRP A 1 217 ? 14.27003  -16.67758 8.22371  1.000 61.12174 ? 218 TRP A N   1 
ATOM   1607 C CA  . TRP A 1 217 ? 14.08166  -15.23421 8.10431  1.000 60.84176 ? 218 TRP A CA  1 
ATOM   1608 C C   . TRP A 1 217 ? 13.11582  -14.66953 9.13669  1.000 60.94997 ? 218 TRP A C   1 
ATOM   1609 O O   . TRP A 1 217 ? 13.19543  -13.47825 9.45668  1.000 61.19234 ? 218 TRP A O   1 
ATOM   1610 C CB  . TRP A 1 217 ? 13.59138  -14.87616 6.69926  1.000 66.68562 ? 218 TRP A CB  1 
ATOM   1611 C CG  . TRP A 1 217 ? 12.18401  -15.31607 6.36774  1.000 68.53002 ? 218 TRP A CG  1 
ATOM   1612 C CD1 . TRP A 1 217 ? 11.81254  -16.48135 5.75970  1.000 69.23715 ? 218 TRP A CD1 1 
ATOM   1613 C CD2 . TRP A 1 217 ? 10.96843  -14.58303 6.59992  1.000 70.72681 ? 218 TRP A CD2 1 
ATOM   1614 N NE1 . TRP A 1 217 ? 10.44589  -16.52388 5.60330  1.000 72.42460 ? 218 TRP A NE1 1 
ATOM   1615 C CE2 . TRP A 1 217 ? 9.90455   -15.37289 6.11320  1.000 71.00650 ? 218 TRP A CE2 1 
ATOM   1616 C CE3 . TRP A 1 217 ? 10.67763  -13.34313 7.17827  1.000 65.89703 ? 218 TRP A CE3 1 
ATOM   1617 C CZ2 . TRP A 1 217 ? 8.57945   -14.96152 6.18266  1.000 74.73420 ? 218 TRP A CZ2 1 
ATOM   1618 C CZ3 . TRP A 1 217 ? 9.36221   -12.93388 7.24143  1.000 70.81204 ? 218 TRP A CZ3 1 
ATOM   1619 C CH2 . TRP A 1 217 ? 8.32691   -13.74003 6.74795  1.000 76.53127 ? 218 TRP A CH2 1 
ATOM   1620 N N   . PHE A 1 218 ? 12.18182  -15.48728 9.64202  1.000 62.06732 ? 219 PHE A N   1 
ATOM   1621 C CA  . PHE A 1 218 ? 11.11144  -15.02147 10.52900 1.000 59.46201 ? 219 PHE A CA  1 
ATOM   1622 C C   . PHE A 1 218 ? 11.55770  -14.91348 11.98584 1.000 56.89281 ? 219 PHE A C   1 
ATOM   1623 O O   . PHE A 1 218 ? 10.85549  -14.27677 12.78524 1.000 52.32525 ? 219 PHE A O   1 
ATOM   1624 C CB  . PHE A 1 218 ? 9.89931   -15.97252 10.42692 1.000 55.94656 ? 219 PHE A CB  1 
ATOM   1625 C CG  . PHE A 1 218 ? 10.29215  -17.41898 10.46392 1.000 53.30996 ? 219 PHE A CG  1 
ATOM   1626 C CD1 . PHE A 1 218 ? 10.53663  -18.05077 11.67340 1.000 52.22476 ? 219 PHE A CD1 1 
ATOM   1627 C CD2 . PHE A 1 218 ? 10.49895  -18.12695 9.29195  1.000 58.26366 ? 219 PHE A CD2 1 
ATOM   1628 C CE1 . PHE A 1 218 ? 10.94880  -19.37468 11.71503 1.000 51.73608 ? 219 PHE A CE1 1 
ATOM   1629 C CE2 . PHE A 1 218 ? 10.91094  -19.45324 9.32571  1.000 61.89525 ? 219 PHE A CE2 1 
ATOM   1630 C CZ  . PHE A 1 218 ? 11.13546  -20.07790 10.53950 1.000 58.23961 ? 219 PHE A CZ  1 
ATOM   1631 N N   . LEU A 1 219 ? 12.68897  -15.53041 12.35043 1.000 50.99070 ? 220 LEU A N   1 
ATOM   1632 C CA  . LEU A 1 219 ? 13.22403  -15.40164 13.70347 1.000 54.35940 ? 220 LEU A CA  1 
ATOM   1633 C C   . LEU A 1 219 ? 13.43257  -13.92905 14.06564 1.000 51.46177 ? 220 LEU A C   1 
ATOM   1634 O O   . LEU A 1 219 ? 13.51813  -13.05808 13.20332 1.000 54.94670 ? 220 LEU A O   1 
ATOM   1635 C CB  . LEU A 1 219 ? 14.53968  -16.16426 13.84012 1.000 51.72467 ? 220 LEU A CB  1 
ATOM   1636 C CG  . LEU A 1 219 ? 14.49945  -17.68777 14.00007 1.000 53.56390 ? 220 LEU A CG  1 
ATOM   1637 C CD1 . LEU A 1 219 ? 15.89513  -18.24529 14.20444 1.000 56.22429 ? 220 LEU A CD1 1 
ATOM   1638 C CD2 . LEU A 1 219 ? 13.59900  -18.10637 15.15965 1.000 57.94348 ? 220 LEU A CD2 1 
ATOM   1639 N N   . ASN A 1 220 ? 13.45926  -13.64664 15.36472 1.000 50.99183 ? 221 ASN A N   1 
ATOM   1640 C CA  . ASN A 1 220 ? 13.67774  -12.29087 15.85047 1.000 52.93427 ? 221 ASN A CA  1 
ATOM   1641 C C   . ASN A 1 220 ? 14.38264  -12.38172 17.19518 1.000 56.69453 ? 221 ASN A C   1 
ATOM   1642 O O   . ASN A 1 220 ? 14.68497  -13.47281 17.68591 1.000 56.59583 ? 221 ASN A O   1 
ATOM   1643 C CB  . ASN A 1 220 ? 12.37884  -11.45406 15.90406 1.000 51.95336 ? 221 ASN A CB  1 
ATOM   1644 C CG  . ASN A 1 220 ? 11.29838  -12.01100 16.87137 1.000 60.89269 ? 221 ASN A CG  1 
ATOM   1645 O OD1 . ASN A 1 220 ? 11.57607  -12.73939 17.82849 1.000 63.53759 ? 221 ASN A OD1 1 
ATOM   1646 N ND2 . ASN A 1 220 ? 10.05616  -11.61857 16.62305 1.000 54.66919 ? 221 ASN A ND2 1 
ATOM   1647 N N   . ARG A 1 221 ? 14.68510  -11.22114 17.77223 1.000 58.36914 ? 222 ARG A N   1 
ATOM   1648 C CA  . ARG A 1 221 ? 15.44250  -11.17399 19.01414 1.000 61.72945 ? 222 ARG A CA  1 
ATOM   1649 C C   . ARG A 1 221 ? 14.55867  -11.20818 20.25807 1.000 58.41655 ? 222 ARG A C   1 
ATOM   1650 O O   . ARG A 1 221 ? 15.07879  -11.38139 21.36406 1.000 58.74296 ? 222 ARG A O   1 
ATOM   1651 C CB  . ARG A 1 221 ? 16.34856  -9.92570  19.02399 1.000 62.62491 ? 222 ARG A CB  1 
ATOM   1652 C CG  . ARG A 1 221 ? 15.67799  -8.61719  19.45218 1.000 65.98542 ? 222 ARG A CG  1 
ATOM   1653 C CD  . ARG A 1 221 ? 16.69022  -7.46509  19.55797 1.000 59.15785 ? 222 ARG A CD  1 
ATOM   1654 N NE  . ARG A 1 221 ? 16.05655  -6.25499  20.07286 1.000 63.15830 ? 222 ARG A NE  1 
ATOM   1655 C CZ  . ARG A 1 221 ? 15.42351  -5.35797  19.32027 1.000 67.73006 ? 222 ARG A CZ  1 
ATOM   1656 N NH1 . ARG A 1 221 ? 15.33175  -5.52773  18.00529 1.000 67.11797 ? 222 ARG A NH1 1 
ATOM   1657 N NH2 . ARG A 1 221 ? 14.86826  -4.29204  19.88320 1.000 67.89882 ? 222 ARG A NH2 1 
ATOM   1658 N N   . PHE A 1 222 ? 13.24572  -11.09533 20.10672 1.000 62.94699 ? 223 PHE A N   1 
ATOM   1659 C CA  . PHE A 1 222 ? 12.34967  -10.95742 21.24661 1.000 64.05665 ? 223 PHE A CA  1 
ATOM   1660 C C   . PHE A 1 222 ? 11.98115  -12.30952 21.85508 1.000 62.69473 ? 223 PHE A C   1 
ATOM   1661 O O   . PHE A 1 222 ? 12.21982  -13.37673 21.28688 1.000 62.25432 ? 223 PHE A O   1 
ATOM   1662 C CB  . PHE A 1 222 ? 11.09406  -10.19817 20.82793 1.000 64.45198 ? 223 PHE A CB  1 
ATOM   1663 C CG  . PHE A 1 222 ? 11.39632  -8.91815  20.11107 1.000 68.68957 ? 223 PHE A CG  1 
ATOM   1664 C CD1 . PHE A 1 222 ? 11.94127  -7.83969  20.79776 1.000 67.61981 ? 223 PHE A CD1 1 
ATOM   1665 C CD2 . PHE A 1 222 ? 11.18217  -8.80459  18.74563 1.000 67.49056 ? 223 PHE A CD2 1 
ATOM   1666 C CE1 . PHE A 1 222 ? 12.24562  -6.66056  20.13866 1.000 68.04257 ? 223 PHE A CE1 1 
ATOM   1667 C CE2 . PHE A 1 222 ? 11.48234  -7.63009  18.07990 1.000 69.02182 ? 223 PHE A CE2 1 
ATOM   1668 C CZ  . PHE A 1 222 ? 12.01725  -6.55739  18.77584 1.000 69.90966 ? 223 PHE A CZ  1 
ATOM   1669 N N   . THR A 1 223 ? 11.41683  -12.24356 23.05573 1.000 68.85131 ? 224 THR A N   1 
ATOM   1670 C CA  . THR A 1 223 ? 10.81595  -13.38001 23.73454 1.000 65.83171 ? 224 THR A CA  1 
ATOM   1671 C C   . THR A 1 223 ? 9.40570   -12.97209 24.12326 1.000 62.31033 ? 224 THR A C   1 
ATOM   1672 O O   . THR A 1 223 ? 9.02652   -11.80710 23.99142 1.000 65.96874 ? 224 THR A O   1 
ATOM   1673 C CB  . THR A 1 223 ? 11.63352  -13.81134 24.96677 1.000 68.46656 ? 224 THR A CB  1 
ATOM   1674 O OG1 . THR A 1 223 ? 11.27525  -15.14784 25.33877 1.000 70.27958 ? 224 THR A OG1 1 
ATOM   1675 C CG2 . THR A 1 223 ? 11.37275  -12.88233 26.14359 1.000 62.98197 ? 224 THR A CG2 1 
ATOM   1676 N N   . THR A 1 224 ? 8.60749   -13.94044 24.56969 1.000 62.29668 ? 225 THR A N   1 
ATOM   1677 C CA  . THR A 1 224 ? 7.25860   -13.64935 25.03955 1.000 60.85646 ? 225 THR A CA  1 
ATOM   1678 C C   . THR A 1 224 ? 6.93784   -14.55969 26.21300 1.000 59.24605 ? 225 THR A C   1 
ATOM   1679 O O   . THR A 1 224 ? 7.49474   -15.65287 26.34265 1.000 62.34191 ? 225 THR A O   1 
ATOM   1680 C CB  . THR A 1 224 ? 6.18421   -13.82509 23.93626 1.000 60.99382 ? 225 THR A CB  1 
ATOM   1681 O OG1 . THR A 1 224 ? 4.98023   -13.14569 24.31467 1.000 59.12753 ? 225 THR A OG1 1 
ATOM   1682 C CG2 . THR A 1 224 ? 5.84711   -15.30477 23.71128 1.000 56.27409 ? 225 THR A CG2 1 
ATOM   1683 N N   . THR A 1 225 ? 6.05556   -14.08937 27.08277 1.000 59.27251 ? 226 THR A N   1 
ATOM   1684 C CA  . THR A 1 225 ? 5.48141   -14.97995 28.07428 1.000 59.19866 ? 226 THR A CA  1 
ATOM   1685 C C   . THR A 1 225 ? 4.30719   -15.72850 27.46196 1.000 56.19214 ? 226 THR A C   1 
ATOM   1686 O O   . THR A 1 225 ? 3.68654   -15.28350 26.48930 1.000 56.61027 ? 226 THR A O   1 
ATOM   1687 C CB  . THR A 1 225 ? 5.02323   -14.21756 29.31670 1.000 61.20423 ? 226 THR A CB  1 
ATOM   1688 O OG1 . THR A 1 225 ? 3.89456   -13.38748 28.99509 1.000 58.45713 ? 226 THR A OG1 1 
ATOM   1689 C CG2 . THR A 1 225 ? 6.15455   -13.37021 29.85808 1.000 59.28844 ? 226 THR A CG2 1 
ATOM   1690 N N   . LEU A 1 226 ? 4.00565   -16.88323 28.05026 1.000 57.26838 ? 227 LEU A N   1 
ATOM   1691 C CA  . LEU A 1 226 ? 2.86159   -17.66372 27.59746 1.000 57.01444 ? 227 LEU A CA  1 
ATOM   1692 C C   . LEU A 1 226 ? 1.56737   -16.84205 27.63583 1.000 55.21220 ? 227 LEU A C   1 
ATOM   1693 O O   . LEU A 1 226 ? 0.77882   -16.87957 26.68763 1.000 56.75232 ? 227 LEU A O   1 
ATOM   1694 C CB  . LEU A 1 226 ? 2.75977   -18.93508 28.43691 1.000 54.86739 ? 227 LEU A CB  1 
ATOM   1695 C CG  . LEU A 1 226 ? 1.63597   -19.93242 28.19713 1.000 58.66024 ? 227 LEU A CG  1 
ATOM   1696 C CD1 . LEU A 1 226 ? 2.20475   -21.30758 28.50456 1.000 55.66064 ? 227 LEU A CD1 1 
ATOM   1697 C CD2 . LEU A 1 226 ? 0.40250   -19.65346 29.05996 1.000 59.49449 ? 227 LEU A CD2 1 
ATOM   1698 N N   . ASN A 1 227 ? 1.34891   -16.06820 28.70462 1.000 54.69126 ? 228 ASN A N   1 
ATOM   1699 C CA  . ASN A 1 227 ? 0.13946   -15.24208 28.75877 1.000 55.49859 ? 228 ASN A CA  1 
ATOM   1700 C C   . ASN A 1 227 ? 0.17326   -14.15003 27.69725 1.000 57.45972 ? 228 ASN A C   1 
ATOM   1701 O O   . ASN A 1 227 ? -0.84643  -13.86996 27.05152 1.000 57.27613 ? 228 ASN A O   1 
ATOM   1702 C CB  . ASN A 1 227 ? -0.03906  -14.62656 30.15317 1.000 59.75882 ? 228 ASN A CB  1 
ATOM   1703 N N   . ASP A 1 228 ? 1.33625   -13.52515 27.49368 1.000 58.39498 ? 229 ASP A N   1 
ATOM   1704 C CA  . ASP A 1 228 ? 1.44906   -12.50388 26.45540 1.000 61.05783 ? 229 ASP A CA  1 
ATOM   1705 C C   . ASP A 1 228 ? 1.15695   -13.08818 25.07719 1.000 58.25895 ? 229 ASP A C   1 
ATOM   1706 O O   . ASP A 1 228 ? 0.51324   -12.44228 24.24025 1.000 57.78999 ? 229 ASP A O   1 
ATOM   1707 C CB  . ASP A 1 228 ? 2.83941   -11.86293 26.48446 1.000 60.02640 ? 229 ASP A CB  1 
ATOM   1708 N N   . PHE A 1 229 ? 1.59947   -14.31956 24.82729 1.000 55.56583 ? 230 PHE A N   1 
ATOM   1709 C CA  . PHE A 1 229 ? 1.32397   -14.92311 23.53079 1.000 53.87332 ? 230 PHE A CA  1 
ATOM   1710 C C   . PHE A 1 229 ? -0.15240  -15.27499 23.38367 1.000 51.18861 ? 230 PHE A C   1 
ATOM   1711 O O   . PHE A 1 229 ? -0.73822  -15.07973 22.31478 1.000 50.54645 ? 230 PHE A O   1 
ATOM   1712 C CB  . PHE A 1 229 ? 2.20208   -16.15499 23.31808 1.000 49.52334 ? 230 PHE A CB  1 
ATOM   1713 C CG  . PHE A 1 229 ? 1.88527   -16.89977 22.05677 1.000 53.56535 ? 230 PHE A CG  1 
ATOM   1714 C CD1 . PHE A 1 229 ? 2.46720   -16.52845 20.85585 1.000 53.28206 ? 230 PHE A CD1 1 
ATOM   1715 C CD2 . PHE A 1 229 ? 0.99578   -17.96492 22.06574 1.000 50.76729 ? 230 PHE A CD2 1 
ATOM   1716 C CE1 . PHE A 1 229 ? 2.17449   -17.19901 19.69317 1.000 55.73887 ? 230 PHE A CE1 1 
ATOM   1717 C CE2 . PHE A 1 229 ? 0.69977   -18.64368 20.90478 1.000 48.94087 ? 230 PHE A CE2 1 
ATOM   1718 C CZ  . PHE A 1 229 ? 1.28167   -18.25870 19.71633 1.000 53.95656 ? 230 PHE A CZ  1 
ATOM   1719 N N   . ASN A 1 230 ? -0.78277  -15.77208 24.44918 1.000 58.49481 ? 231 ASN A N   1 
ATOM   1720 C CA  . ASN A 1 230 ? -2.17085  -16.21522 24.32939 1.000 50.12973 ? 231 ASN A CA  1 
ATOM   1721 C C   . ASN A 1 230 ? -3.13770  -15.06412 24.08711 1.000 52.65306 ? 231 ASN A C   1 
ATOM   1722 O O   . ASN A 1 230 ? -4.21125  -15.28779 23.51816 1.000 51.89984 ? 231 ASN A O   1 
ATOM   1723 C CB  . ASN A 1 230 ? -2.55611  -17.01511 25.55761 1.000 43.60994 ? 231 ASN A CB  1 
ATOM   1724 C CG  . ASN A 1 230 ? -1.96063  -18.40331 25.53780 1.000 50.56889 ? 231 ASN A CG  1 
ATOM   1725 O OD1 . ASN A 1 230 ? -1.69746  -18.96195 24.47465 1.000 49.88193 ? 231 ASN A OD1 1 
ATOM   1726 N ND2 . ASN A 1 230 ? -1.73190  -18.96596 26.71210 1.000 57.43739 ? 231 ASN A ND2 1 
ATOM   1727 N N   . LEU A 1 231 ? -2.77458  -13.83268 24.45076 1.000 54.46619 ? 232 LEU A N   1 
ATOM   1728 C CA  . LEU A 1 231 ? -3.60802  -12.69701 24.05348 1.000 56.78063 ? 232 LEU A CA  1 
ATOM   1729 C C   . LEU A 1 231 ? -3.53901  -12.45580 22.54717 1.000 56.39110 ? 232 LEU A C   1 
ATOM   1730 O O   . LEU A 1 231 ? -4.55281  -12.12746 21.92068 1.000 57.17749 ? 232 LEU A O   1 
ATOM   1731 C CB  . LEU A 1 231 ? -3.19491  -11.43781 24.80752 1.000 60.89205 ? 232 LEU A CB  1 
ATOM   1732 C CG  . LEU A 1 231 ? -3.37388  -11.45161 26.32115 1.000 63.29929 ? 232 LEU A CG  1 
ATOM   1733 C CD1 . LEU A 1 231 ? -2.25715  -10.64400 26.98960 1.000 56.80996 ? 232 LEU A CD1 1 
ATOM   1734 C CD2 . LEU A 1 231 ? -4.75243  -10.90935 26.71000 1.000 58.65078 ? 232 LEU A CD2 1 
ATOM   1735 N N   . VAL A 1 232 ? -2.35479  -12.61086 21.94064 1.000 59.03850 ? 233 VAL A N   1 
ATOM   1736 C CA  . VAL A 1 232 ? -2.28468  -12.50959 20.48471 1.000 57.07826 ? 233 VAL A CA  1 
ATOM   1737 C C   . VAL A 1 232 ? -2.97633  -13.70695 19.84248 1.000 59.21284 ? 233 VAL A C   1 
ATOM   1738 O O   . VAL A 1 232 ? -3.64084  -13.57747 18.80554 1.000 58.65445 ? 233 VAL A O   1 
ATOM   1739 C CB  . VAL A 1 232 ? -0.82672  -12.37582 20.00564 1.000 55.55400 ? 233 VAL A CB  1 
ATOM   1740 N N   . ALA A 1 233 ? -2.83871  -14.88707 20.45250 1.000 53.84437 ? 234 ALA A N   1 
ATOM   1741 C CA  . ALA A 1 233 ? -3.42591  -16.08734 19.87359 1.000 55.89944 ? 234 ALA A CA  1 
ATOM   1742 C C   . ALA A 1 233 ? -4.94362  -15.98848 19.82252 1.000 54.65459 ? 234 ALA A C   1 
ATOM   1743 O O   . ALA A 1 233 ? -5.56963  -16.44724 18.86209 1.000 53.56465 ? 234 ALA A O   1 
ATOM   1744 C CB  . ALA A 1 233 ? -2.98975  -17.32267 20.66292 1.000 53.68837 ? 234 ALA A CB  1 
ATOM   1745 N N   . MET A 1 234 ? -5.55455  -15.38279 20.83949 1.000 57.59757 ? 235 MET A N   1 
ATOM   1746 C CA  . MET A 1 234 ? -7.00697  -15.29723 20.84677 1.000 55.21025 ? 235 MET A CA  1 
ATOM   1747 C C   . MET A 1 234 ? -7.50467  -14.35214 19.76769 1.000 59.66736 ? 235 MET A C   1 
ATOM   1748 O O   . MET A 1 234 ? -8.55731  -14.59914 19.16836 1.000 60.87859 ? 235 MET A O   1 
ATOM   1749 C CB  . MET A 1 234 ? -7.50363  -14.85293 22.22001 1.000 59.02890 ? 235 MET A CB  1 
ATOM   1750 C CG  . MET A 1 234 ? -8.99929  -15.06547 22.44118 1.000 71.38607 ? 235 MET A CG  1 
ATOM   1751 S SD  . MET A 1 234 ? -9.44275  -14.86003 24.18345 1.000 82.48109 ? 235 MET A SD  1 
ATOM   1752 C CE  . MET A 1 234 ? -8.06650  -13.82603 24.66603 1.000 74.37817 ? 235 MET A CE  1 
ATOM   1753 N N   . LYS A 1 235 ? -6.75030  -13.28492 19.49163 1.000 56.97503 ? 236 LYS A N   1 
ATOM   1754 C CA  . LYS A 1 235 ? -7.16770  -12.31460 18.48552 1.000 60.35749 ? 236 LYS A CA  1 
ATOM   1755 C C   . LYS A 1 235 ? -7.19496  -12.92685 17.09456 1.000 60.45133 ? 236 LYS A C   1 
ATOM   1756 O O   . LYS A 1 235 ? -7.96938  -12.48741 16.23853 1.000 63.03712 ? 236 LYS A O   1 
ATOM   1757 C CB  . LYS A 1 235 ? -6.23579  -11.09825 18.50252 1.000 56.95508 ? 236 LYS A CB  1 
ATOM   1758 N N   . TYR A 1 236 ? -6.36631  -13.94015 16.85625 1.000 58.33119 ? 237 TYR A N   1 
ATOM   1759 C CA  . TYR A 1 236 ? -6.17301  -14.51617 15.53438 1.000 58.00108 ? 237 TYR A CA  1 
ATOM   1760 C C   . TYR A 1 236 ? -6.73077  -15.92981 15.41974 1.000 57.14067 ? 237 TYR A C   1 
ATOM   1761 O O   . TYR A 1 236 ? -6.30678  -16.68045 14.53665 1.000 55.93451 ? 237 TYR A O   1 
ATOM   1762 C CB  . TYR A 1 236 ? -4.68963  -14.51886 15.17872 1.000 56.23301 ? 237 TYR A CB  1 
ATOM   1763 C CG  . TYR A 1 236 ? -4.14434  -13.15993 14.83195 1.000 62.62224 ? 237 TYR A CG  1 
ATOM   1764 C CD1 . TYR A 1 236 ? -4.20200  -12.67816 13.53050 1.000 62.16659 ? 237 TYR A CD1 1 
ATOM   1765 C CD2 . TYR A 1 236 ? -3.57105  -12.35779 15.80552 1.000 63.98699 ? 237 TYR A CD2 1 
ATOM   1766 C CE1 . TYR A 1 236 ? -3.70025  -11.43661 13.20735 1.000 68.08121 ? 237 TYR A CE1 1 
ATOM   1767 C CE2 . TYR A 1 236 ? -3.06326  -11.11531 15.49398 1.000 69.55642 ? 237 TYR A CE2 1 
ATOM   1768 C CZ  . TYR A 1 236 ? -3.12607  -10.65627 14.19414 1.000 72.25791 ? 237 TYR A CZ  1 
ATOM   1769 O OH  . TYR A 1 236 ? -2.61045  -9.41164  13.89123 1.000 71.55118 ? 237 TYR A OH  1 
ATOM   1770 N N   . ASN A 1 237 ? -7.65498  -16.31112 16.30579 1.000 54.77395 ? 238 ASN A N   1 
ATOM   1771 C CA  . ASN A 1 237 ? -8.32024  -17.61247 16.24584 1.000 53.99861 ? 238 ASN A CA  1 
ATOM   1772 C C   . ASN A 1 237 ? -7.31861  -18.76572 16.27682 1.000 50.94900 ? 238 ASN A C   1 
ATOM   1773 O O   . ASN A 1 237 ? -7.41693  -19.72097 15.50955 1.000 49.55568 ? 238 ASN A O   1 
ATOM   1774 C CB  . ASN A 1 237 ? -9.22006  -17.70822 15.01414 1.000 56.53328 ? 238 ASN A CB  1 
ATOM   1775 C CG  . ASN A 1 237 ? -10.27540 -18.78312 15.15317 1.000 57.10838 ? 238 ASN A CG  1 
ATOM   1776 O OD1 . ASN A 1 237 ? -10.85379 -18.95978 16.22328 1.000 64.19513 ? 238 ASN A OD1 1 
ATOM   1777 N ND2 . ASN A 1 237 ? -10.52499 -19.51480 14.07390 1.000 55.23422 ? 238 ASN A ND2 1 
ATOM   1778 N N   . TYR A 1 238 ? -6.35146  -18.67182 17.18233 1.000 49.18155 ? 239 TYR A N   1 
ATOM   1779 C CA  . TYR A 1 238 ? -5.37914  -19.72616 17.41521 1.000 51.00662 ? 239 TYR A CA  1 
ATOM   1780 C C   . TYR A 1 238 ? -5.65705  -20.35767 18.76550 1.000 47.62598 ? 239 TYR A C   1 
ATOM   1781 O O   . TYR A 1 238 ? -6.08546  -19.67583 19.69325 1.000 49.09980 ? 239 TYR A O   1 
ATOM   1782 C CB  . TYR A 1 238 ? -3.94109  -19.19055 17.41198 1.000 49.61928 ? 239 TYR A CB  1 
ATOM   1783 C CG  . TYR A 1 238 ? -3.24626  -19.18254 16.07714 1.000 46.93991 ? 239 TYR A CG  1 
ATOM   1784 C CD1 . TYR A 1 238 ? -3.74547  -18.44015 15.01929 1.000 50.68135 ? 239 TYR A CD1 1 
ATOM   1785 C CD2 . TYR A 1 238 ? -2.07531  -19.90088 15.87942 1.000 47.76497 ? 239 TYR A CD2 1 
ATOM   1786 C CE1 . TYR A 1 238 ? -3.09942  -18.41159 13.80101 1.000 50.97083 ? 239 TYR A CE1 1 
ATOM   1787 C CE2 . TYR A 1 238 ? -1.42048  -19.88306 14.65735 1.000 49.00998 ? 239 TYR A CE2 1 
ATOM   1788 C CZ  . TYR A 1 238 ? -1.94256  -19.13123 13.62366 1.000 50.24092 ? 239 TYR A CZ  1 
ATOM   1789 O OH  . TYR A 1 238 ? -1.30840  -19.09675 12.40134 1.000 59.32395 ? 239 TYR A OH  1 
ATOM   1790 N N   . GLU A 1 239 ? -5.39609  -21.65617 18.87058 1.000 46.61399 ? 240 GLU A N   1 
ATOM   1791 C CA  . GLU A 1 239 ? -5.55115  -22.34012 20.14344 1.000 45.06713 ? 240 GLU A CA  1 
ATOM   1792 C C   . GLU A 1 239 ? -4.57554  -21.75915 21.16198 1.000 45.72094 ? 240 GLU A C   1 
ATOM   1793 O O   . GLU A 1 239 ? -3.42760  -21.46442 20.82097 1.000 47.14073 ? 240 GLU A O   1 
ATOM   1794 C CB  . GLU A 1 239 ? -5.29768  -23.84285 19.99436 1.000 47.50389 ? 240 GLU A CB  1 
ATOM   1795 C CG  . GLU A 1 239 ? -6.42931  -24.59236 19.31413 1.000 47.22137 ? 240 GLU A CG  1 
ATOM   1796 C CD  . GLU A 1 239 ? -6.35517  -26.10171 19.50240 1.000 52.71010 ? 240 GLU A CD  1 
ATOM   1797 O OE1 . GLU A 1 239 ? -5.29967  -26.69539 19.19295 1.000 46.81198 ? 240 GLU A OE1 1 
ATOM   1798 O OE2 . GLU A 1 239 ? -7.37248  -26.70387 19.94351 1.000 58.09053 ? 240 GLU A OE2 1 
ATOM   1799 N N   . PRO A 1 240 ? -4.99537  -21.58649 22.41426 1.000 49.23203 ? 241 PRO A N   1 
ATOM   1800 C CA  . PRO A 1 240 ? -4.04773  -21.12350 23.43459 1.000 48.03142 ? 241 PRO A CA  1 
ATOM   1801 C C   . PRO A 1 240 ? -2.87881  -22.09206 23.55441 1.000 50.36817 ? 241 PRO A C   1 
ATOM   1802 O O   . PRO A 1 240 ? -2.99298  -23.28180 23.25753 1.000 51.11763 ? 241 PRO A O   1 
ATOM   1803 C CB  . PRO A 1 240 ? -4.88832  -21.08464 24.71783 1.000 46.29704 ? 241 PRO A CB  1 
ATOM   1804 C CG  . PRO A 1 240 ? -6.32349  -20.99801 24.24390 1.000 42.74346 ? 241 PRO A CG  1 
ATOM   1805 C CD  . PRO A 1 240 ? -6.35984  -21.76564 22.95003 1.000 43.06051 ? 241 PRO A CD  1 
ATOM   1806 N N   . LEU A 1 241 ? -1.73034  -21.56947 23.95857 1.000 48.13345 ? 242 LEU A N   1 
ATOM   1807 C CA  . LEU A 1 241 ? -0.57746  -22.42008 24.18946 1.000 49.77025 ? 242 LEU A CA  1 
ATOM   1808 C C   . LEU A 1 241 ? -0.50020  -22.76071 25.66677 1.000 49.58999 ? 242 LEU A C   1 
ATOM   1809 O O   . LEU A 1 241 ? -0.68778  -21.89308 26.52181 1.000 48.54122 ? 242 LEU A O   1 
ATOM   1810 C CB  . LEU A 1 241 ? 0.72577   -21.75576 23.73156 1.000 48.55193 ? 242 LEU A CB  1 
ATOM   1811 C CG  . LEU A 1 241 ? 1.84552   -22.77043 23.47370 1.000 53.81814 ? 242 LEU A CG  1 
ATOM   1812 C CD1 . LEU A 1 241 ? 1.43213   -23.75865 22.38581 1.000 54.73500 ? 242 LEU A CD1 1 
ATOM   1813 C CD2 . LEU A 1 241 ? 3.11074   -22.07594 23.05768 1.000 44.48934 ? 242 LEU A CD2 1 
ATOM   1814 N N   . THR A 1 242 ? -0.22083  -24.02633 25.95654 1.000 49.26652 ? 243 THR A N   1 
ATOM   1815 C CA  . THR A 1 242 ? -0.08891  -24.52139 27.31613 1.000 47.37721 ? 243 THR A CA  1 
ATOM   1816 C C   . THR A 1 242 ? 1.33800   -24.96783 27.59605 1.000 49.06279 ? 243 THR A C   1 
ATOM   1817 O O   . THR A 1 242 ? 2.15210   -25.17990 26.68478 1.000 52.69866 ? 243 THR A O   1 
ATOM   1818 C CB  . THR A 1 242 ? -1.03300  -25.69773 27.55570 1.000 47.49636 ? 243 THR A CB  1 
ATOM   1819 O OG1 . THR A 1 242 ? -0.63775  -26.78855 26.71844 1.000 46.59198 ? 243 THR A OG1 1 
ATOM   1820 C CG2 . THR A 1 242 ? -2.45796  -25.30161 27.22448 1.000 47.28819 ? 243 THR A CG2 1 
ATOM   1821 N N   . GLN A 1 243 ? 1.61594   -25.15056 28.88725 1.000 46.65647 ? 244 GLN A N   1 
ATOM   1822 C CA  . GLN A 1 243 ? 2.89507   -25.71551 29.29801 1.000 52.85797 ? 244 GLN A CA  1 
ATOM   1823 C C   . GLN A 1 243 ? 3.09981   -27.10733 28.70440 1.000 52.13196 ? 244 GLN A C   1 
ATOM   1824 O O   . GLN A 1 243 ? 4.21982   -27.46922 28.32678 1.000 52.69551 ? 244 GLN A O   1 
ATOM   1825 C CB  . GLN A 1 243 ? 2.98364   -25.75206 30.82298 1.000 49.13089 ? 244 GLN A CB  1 
ATOM   1826 C CG  . GLN A 1 243 ? 4.36314   -26.10406 31.32505 1.000 53.91748 ? 244 GLN A CG  1 
ATOM   1827 C CD  . GLN A 1 243 ? 5.43529   -25.18935 30.75240 1.000 53.38665 ? 244 GLN A CD  1 
ATOM   1828 O OE1 . GLN A 1 243 ? 6.41729   -25.65188 30.17633 1.000 54.41414 ? 244 GLN A OE1 1 
ATOM   1829 N NE2 . GLN A 1 243 ? 5.25307   -23.88468 30.91907 1.000 51.32580 ? 244 GLN A NE2 1 
ATOM   1830 N N   . ASP A 1 244 ? 2.02417   -27.89347 28.60145 1.000 48.56222 ? 245 ASP A N   1 
ATOM   1831 C CA  . ASP A 1 244 ? 2.11562   -29.21942 27.99567 1.000 51.12442 ? 245 ASP A CA  1 
ATOM   1832 C C   . ASP A 1 244 ? 2.61502   -29.14529 26.56020 1.000 50.91698 ? 245 ASP A C   1 
ATOM   1833 O O   . ASP A 1 244 ? 3.37175   -30.01574 26.11429 1.000 53.66526 ? 245 ASP A O   1 
ATOM   1834 C CB  . ASP A 1 244 ? 0.75378   -29.91847 28.02701 1.000 50.23497 ? 245 ASP A CB  1 
ATOM   1835 C CG  . ASP A 1 244 ? 0.41401   -30.49447 29.39222 1.000 55.17637 ? 245 ASP A CG  1 
ATOM   1836 O OD1 . ASP A 1 244 ? 1.32058   -31.04903 30.03960 1.000 58.28054 ? 245 ASP A OD1 1 
ATOM   1837 O OD2 . ASP A 1 244 ? -0.76084  -30.38649 29.82088 1.000 59.81835 ? 245 ASP A OD2 1 
ATOM   1838 N N   . HIS A 1 245 ? 2.16200   -28.14133 25.80876 1.000 50.36885 ? 246 HIS A N   1 
ATOM   1839 C CA  . HIS A 1 245 ? 2.66180   -27.94908 24.45411 1.000 50.40088 ? 246 HIS A CA  1 
ATOM   1840 C C   . HIS A 1 245 ? 4.13635   -27.56002 24.47401 1.000 51.20736 ? 246 HIS A C   1 
ATOM   1841 O O   . HIS A 1 245 ? 4.94693   -28.12921 23.73275 1.000 49.77220 ? 246 HIS A O   1 
ATOM   1842 C CB  . HIS A 1 245 ? 1.83574   -26.88266 23.74168 1.000 52.03312 ? 246 HIS A CB  1 
ATOM   1843 C CG  . HIS A 1 245 ? 0.40438   -27.26431 23.52713 1.000 53.92280 ? 246 HIS A CG  1 
ATOM   1844 N ND1 . HIS A 1 245 ? -0.55656  -26.35932 23.12228 1.000 57.92743 ? 246 HIS A ND1 1 
ATOM   1845 C CD2 . HIS A 1 245 ? -0.22763  -28.45572 23.64741 1.000 54.09434 ? 246 HIS A CD2 1 
ATOM   1846 C CE1 . HIS A 1 245 ? -1.71944  -26.97621 23.01340 1.000 56.11448 ? 246 HIS A CE1 1 
ATOM   1847 N NE2 . HIS A 1 245 ? -1.54732  -28.24860 23.32642 1.000 56.43403 ? 246 HIS A NE2 1 
ATOM   1848 N N   . VAL A 1 246 ? 4.49789   -26.59661 25.33176 1.000 51.17863 ? 247 VAL A N   1 
ATOM   1849 C CA  . VAL A 1 246 ? 5.89461   -26.19273 25.48909 1.000 51.90755 ? 247 VAL A CA  1 
ATOM   1850 C C   . VAL A 1 246 ? 6.77222   -27.40390 25.76763 1.000 51.74020 ? 247 VAL A C   1 
ATOM   1851 O O   . VAL A 1 246 ? 7.86165   -27.53968 25.19512 1.000 51.62687 ? 247 VAL A O   1 
ATOM   1852 C CB  . VAL A 1 246 ? 6.02392   -25.12970 26.59841 1.000 50.70329 ? 247 VAL A CB  1 
ATOM   1853 C CG1 . VAL A 1 246 ? 7.49148   -24.76545 26.83484 1.000 49.39081 ? 247 VAL A CG1 1 
ATOM   1854 C CG2 . VAL A 1 246 ? 5.21038   -23.89705 26.24171 1.000 47.81607 ? 247 VAL A CG2 1 
ATOM   1855 N N   . ASP A 1 247 ? 6.30169   -28.31279 26.63189 1.000 49.67635 ? 248 ASP A N   1 
ATOM   1856 C CA  . ASP A 1 247 ? 7.06044   -29.52548 26.92528 1.000 50.75218 ? 248 ASP A CA  1 
ATOM   1857 C C   . ASP A 1 247 ? 7.18039   -30.41021 25.69552 1.000 52.48842 ? 248 ASP A C   1 
ATOM   1858 O O   . ASP A 1 247 ? 8.22214   -31.03284 25.47338 1.000 57.61890 ? 248 ASP A O   1 
ATOM   1859 C CB  . ASP A 1 247 ? 6.41323   -30.32687 28.05962 1.000 53.79330 ? 248 ASP A CB  1 
ATOM   1860 C CG  . ASP A 1 247 ? 6.47958   -29.62385 29.40327 1.000 56.70974 ? 248 ASP A CG  1 
ATOM   1861 O OD1 . ASP A 1 247 ? 7.33404   -28.74339 29.58986 1.000 66.99565 ? 248 ASP A OD1 1 
ATOM   1862 O OD2 . ASP A 1 247 ? 5.68714   -29.97774 30.29520 1.000 63.81703 ? 248 ASP A OD2 1 
ATOM   1863 N N   . ILE A 1 248 ? 6.12101   -30.49229 24.89094 1.000 49.36005 ? 249 ILE A N   1 
ATOM   1864 C CA  . ILE A 1 248 ? 6.14585   -31.38588 23.73617 1.000 49.76077 ? 249 ILE A CA  1 
ATOM   1865 C C   . ILE A 1 248 ? 7.15322   -30.89123 22.70720 1.000 51.84130 ? 249 ILE A C   1 
ATOM   1866 O O   . ILE A 1 248 ? 7.79728   -31.69072 22.01191 1.000 52.48097 ? 249 ILE A O   1 
ATOM   1867 C CB  . ILE A 1 248 ? 4.72892   -31.51324 23.14270 1.000 52.74399 ? 249 ILE A CB  1 
ATOM   1868 C CG1 . ILE A 1 248 ? 3.86794   -32.43303 24.01090 1.000 54.06283 ? 249 ILE A CG1 1 
ATOM   1869 C CG2 . ILE A 1 248 ? 4.75871   -32.02789 21.71481 1.000 51.70791 ? 249 ILE A CG2 1 
ATOM   1870 C CD1 . ILE A 1 248 ? 2.39825   -32.17373 23.85869 1.000 53.06122 ? 249 ILE A CD1 1 
ATOM   1871 N N   . LEU A 1 249 ? 7.32915   -29.58048 22.61780 1.000 47.66672 ? 250 LEU A N   1 
ATOM   1872 C CA  . LEU A 1 249 ? 8.25122   -28.97755 21.67535 1.000 52.99046 ? 250 LEU A CA  1 
ATOM   1873 C C   . LEU A 1 249 ? 9.70479   -28.98090 22.17281 1.000 53.59825 ? 250 LEU A C   1 
ATOM   1874 O O   . LEU A 1 249 ? 10.56199  -28.41274 21.50223 1.000 51.92375 ? 250 LEU A O   1 
ATOM   1875 C CB  . LEU A 1 249 ? 7.79086   -27.55192 21.36099 1.000 47.25671 ? 250 LEU A CB  1 
ATOM   1876 C CG  . LEU A 1 249 ? 6.50612   -27.45098 20.53722 1.000 43.81963 ? 250 LEU A CG  1 
ATOM   1877 C CD1 . LEU A 1 249 ? 5.93776   -26.04730 20.53017 1.000 39.52887 ? 250 LEU A CD1 1 
ATOM   1878 C CD2 . LEU A 1 249 ? 6.73703   -27.91678 19.12608 1.000 48.66644 ? 250 LEU A CD2 1 
ATOM   1879 N N   . GLY A 1 250 ? 9.98754   -29.60496 23.31741 1.000 55.30895 ? 251 GLY A N   1 
ATOM   1880 C CA  . GLY A 1 250 ? 11.31239  -29.62892 23.88924 1.000 55.42947 ? 251 GLY A CA  1 
ATOM   1881 C C   . GLY A 1 250 ? 12.38820  -30.14321 22.94682 1.000 59.17809 ? 251 GLY A C   1 
ATOM   1882 O O   . GLY A 1 250 ? 13.30344  -29.40612 22.56635 1.000 61.24829 ? 251 GLY A O   1 
ATOM   1883 N N   . PRO A 1 251 ? 12.31441  -31.42743 22.57281 1.000 56.57027 ? 252 PRO A N   1 
ATOM   1884 C CA  . PRO A 1 251 ? 13.29597  -31.97609 21.61826 1.000 61.08510 ? 252 PRO A CA  1 
ATOM   1885 C C   . PRO A 1 251 ? 13.52847  -31.11000 20.38835 1.000 62.52136 ? 252 PRO A C   1 
ATOM   1886 O O   . PRO A 1 251 ? 14.68406  -30.91743 19.98252 1.000 61.45098 ? 252 PRO A O   1 
ATOM   1887 C CB  . PRO A 1 251 ? 12.68096  -33.33121 21.24763 1.000 59.07317 ? 252 PRO A CB  1 
ATOM   1888 C CG  . PRO A 1 251 ? 11.94326  -33.73480 22.45397 1.000 54.12783 ? 252 PRO A CG  1 
ATOM   1889 C CD  . PRO A 1 251 ? 11.48265  -32.48606 23.16243 1.000 54.81267 ? 252 PRO A CD  1 
ATOM   1890 N N   . LEU A 1 252 ? 12.46206  -30.57987 19.78267 1.000 55.61883 ? 253 LEU A N   1 
ATOM   1891 C CA  . LEU A 1 252 ? 12.63530  -29.67445 18.65184 1.000 55.59337 ? 253 LEU A CA  1 
ATOM   1892 C C   . LEU A 1 252 ? 13.37019  -28.40483 19.06566 1.000 61.63532 ? 253 LEU A C   1 
ATOM   1893 O O   . LEU A 1 252 ? 14.18236  -27.87541 18.29916 1.000 60.83654 ? 253 LEU A O   1 
ATOM   1894 C CB  . LEU A 1 252 ? 11.28348  -29.31754 18.04635 1.000 53.94902 ? 253 LEU A CB  1 
ATOM   1895 C CG  . LEU A 1 252 ? 10.75232  -30.29979 16.99980 1.000 60.03541 ? 253 LEU A CG  1 
ATOM   1896 C CD1 . LEU A 1 252 ? 9.52244   -29.73339 16.29232 1.000 45.58482 ? 253 LEU A CD1 1 
ATOM   1897 C CD2 . LEU A 1 252 ? 11.84324  -30.63783 15.99689 1.000 54.49613 ? 253 LEU A CD2 1 
ATOM   1898 N N   . SER A 1 253 ? 13.07854  -27.88425 20.26466 1.000 58.99418 ? 254 SER A N   1 
ATOM   1899 C CA  . SER A 1 253 ? 13.75964  -26.67770 20.72644 1.000 60.29657 ? 254 SER A CA  1 
ATOM   1900 C C   . SER A 1 253 ? 15.24884  -26.92535 20.90374 1.000 62.38563 ? 254 SER A C   1 
ATOM   1901 O O   . SER A 1 253 ? 16.07317  -26.09224 20.51335 1.000 62.01204 ? 254 SER A O   1 
ATOM   1902 C CB  . SER A 1 253 ? 13.15109  -26.18533 22.03770 1.000 61.33129 ? 254 SER A CB  1 
ATOM   1903 O OG  . SER A 1 253 ? 13.69940  -24.92713 22.40303 1.000 59.32234 ? 254 SER A OG  1 
ATOM   1904 N N   . ALA A 1 254 ? 15.60483  -28.07976 21.46957 1.000 66.70695 ? 255 ALA A N   1 
ATOM   1905 C CA  . ALA A 1 254 ? 17.00490  -28.41956 21.68637 1.000 62.49208 ? 255 ALA A CA  1 
ATOM   1906 C C   . ALA A 1 254 ? 17.75725  -28.53929 20.36257 1.000 69.13351 ? 255 ALA A C   1 
ATOM   1907 O O   . ALA A 1 254 ? 18.83523  -27.95508 20.19397 1.000 68.03887 ? 255 ALA A O   1 
ATOM   1908 C CB  . ALA A 1 254 ? 17.09102  -29.71629 22.49174 1.000 60.56546 ? 255 ALA A CB  1 
ATOM   1909 N N   . GLN A 1 255 ? 17.18361  -29.27290 19.40214 1.000 69.50671 ? 256 GLN A N   1 
ATOM   1910 C CA  . GLN A 1 255 ? 17.84553  -29.51701 18.12282 1.000 67.14161 ? 256 GLN A CA  1 
ATOM   1911 C C   . GLN A 1 255 ? 18.23550  -28.22218 17.42033 1.000 66.46338 ? 256 GLN A C   1 
ATOM   1912 O O   . GLN A 1 255 ? 19.27637  -28.16016 16.76086 1.000 71.50910 ? 256 GLN A O   1 
ATOM   1913 C CB  . GLN A 1 255 ? 16.93756  -30.35499 17.21636 1.000 67.32095 ? 256 GLN A CB  1 
ATOM   1914 C CG  . GLN A 1 255 ? 17.62212  -30.88439 15.96042 1.000 74.73098 ? 256 GLN A CG  1 
ATOM   1915 C CD  . GLN A 1 255 ? 16.68036  -31.64115 15.02927 1.000 77.66168 ? 256 GLN A CD  1 
ATOM   1916 O OE1 . GLN A 1 255 ? 15.54564  -31.96102 15.39068 1.000 75.47169 ? 256 GLN A OE1 1 
ATOM   1917 N NE2 . GLN A 1 255 ? 17.15270  -31.92640 13.81743 1.000 77.17794 ? 256 GLN A NE2 1 
ATOM   1918 N N   . THR A 1 256 ? 17.41909  -27.17937 17.54245 1.000 66.38655 ? 257 THR A N   1 
ATOM   1919 C CA  . THR A 1 256 ? 17.65914  -25.92593 16.83553 1.000 64.34262 ? 257 THR A CA  1 
ATOM   1920 C C   . THR A 1 256 ? 18.21090  -24.81908 17.72342 1.000 63.04104 ? 257 THR A C   1 
ATOM   1921 O O   . THR A 1 256 ? 18.47778  -23.72117 17.22094 1.000 65.80209 ? 257 THR A O   1 
ATOM   1922 C CB  . THR A 1 256 ? 16.36790  -25.43323 16.18382 1.000 60.50630 ? 257 THR A CB  1 
ATOM   1923 O OG1 . THR A 1 256 ? 15.45848  -25.01125 17.20892 1.000 61.82969 ? 257 THR A OG1 1 
ATOM   1924 C CG2 . THR A 1 256 ? 15.74347  -26.53755 15.36830 1.000 61.17731 ? 257 THR A CG2 1 
ATOM   1925 N N   . GLY A 1 257 ? 18.36580  -25.06760 19.02277 1.000 60.05010 ? 258 GLY A N   1 
ATOM   1926 C CA  . GLY A 1 257 ? 18.78131  -24.03997 19.95768 1.000 58.34032 ? 258 GLY A CA  1 
ATOM   1927 C C   . GLY A 1 257 ? 17.83487  -22.86113 20.14422 1.000 64.87432 ? 258 GLY A C   1 
ATOM   1928 O O   . GLY A 1 257 ? 18.20381  -21.89160 20.81774 1.000 63.33208 ? 258 GLY A O   1 
ATOM   1929 N N   . ILE A 1 258 ? 16.62111  -22.90624 19.59099 1.000 59.54050 ? 259 ILE A N   1 
ATOM   1930 C CA  . ILE A 1 258 ? 15.69117  -21.77942 19.68995 1.000 58.15717 ? 259 ILE A CA  1 
ATOM   1931 C C   . ILE A 1 258 ? 14.64074  -22.08267 20.74808 1.000 60.82196 ? 259 ILE A C   1 
ATOM   1932 O O   . ILE A 1 258 ? 13.80729  -22.98411 20.57379 1.000 61.76132 ? 259 ILE A O   1 
ATOM   1933 C CB  . ILE A 1 258 ? 15.02728  -21.46121 18.34435 1.000 57.80408 ? 259 ILE A CB  1 
ATOM   1934 C CG1 . ILE A 1 258 ? 16.08789  -21.18461 17.28580 1.000 58.64018 ? 259 ILE A CG1 1 
ATOM   1935 C CG2 . ILE A 1 258 ? 14.09355  -20.26600 18.49909 1.000 52.50381 ? 259 ILE A CG2 1 
ATOM   1936 C CD1 . ILE A 1 258 ? 15.70334  -21.69073 15.93446 1.000 62.35541 ? 259 ILE A CD1 1 
ATOM   1937 N N   . ALA A 1 259 ? 14.65888  -21.30632 21.82980 1.000 57.94990 ? 260 ALA A N   1 
ATOM   1938 C CA  . ALA A 1 259 ? 13.73563  -21.52740 22.93120 1.000 58.03760 ? 260 ALA A CA  1 
ATOM   1939 C C   . ALA A 1 259 ? 12.28768  -21.40739 22.45560 1.000 55.89337 ? 260 ALA A C   1 
ATOM   1940 O O   . ALA A 1 259 ? 11.95525  -20.60620 21.57839 1.000 54.75724 ? 260 ALA A O   1 
ATOM   1941 C CB  . ALA A 1 259 ? 14.01368  -20.53453 24.06237 1.000 57.91594 ? 260 ALA A CB  1 
ATOM   1942 N N   . VAL A 1 260 ? 11.42313  -22.22790 23.05081 1.000 58.04580 ? 261 VAL A N   1 
ATOM   1943 C CA  . VAL A 1 260 ? 10.02893  -22.31029 22.61074 1.000 50.33545 ? 261 VAL A CA  1 
ATOM   1944 C C   . VAL A 1 260 ? 9.37003   -20.94250 22.67447 1.000 49.69190 ? 261 VAL A C   1 
ATOM   1945 O O   . VAL A 1 260 ? 8.73519   -20.49100 21.71206 1.000 48.17407 ? 261 VAL A O   1 
ATOM   1946 C CB  . VAL A 1 260 ? 9.26834   -23.35102 23.45585 1.000 54.19579 ? 261 VAL A CB  1 
ATOM   1947 C CG1 . VAL A 1 260 ? 7.76300   -23.21170 23.26228 1.000 47.09748 ? 261 VAL A CG1 1 
ATOM   1948 C CG2 . VAL A 1 260 ? 9.75514   -24.77726 23.13553 1.000 50.16172 ? 261 VAL A CG2 1 
ATOM   1949 N N   . LEU A 1 261 ? 9.53068   -20.24314 23.79898 1.000 53.48042 ? 262 LEU A N   1 
ATOM   1950 C CA  . LEU A 1 261 ? 8.97651   -18.89774 23.91522 1.000 51.00856 ? 262 LEU A CA  1 
ATOM   1951 C C   . LEU A 1 261 ? 9.63693   -17.90377 22.96038 1.000 54.74524 ? 262 LEU A C   1 
ATOM   1952 O O   . LEU A 1 261 ? 8.99642   -16.91969 22.57398 1.000 56.54186 ? 262 LEU A O   1 
ATOM   1953 C CB  . LEU A 1 261 ? 9.07287   -18.42043 25.36323 1.000 54.25710 ? 262 LEU A CB  1 
ATOM   1954 C CG  . LEU A 1 261 ? 8.11514   -19.25121 26.23442 1.000 57.18712 ? 262 LEU A CG  1 
ATOM   1955 C CD1 . LEU A 1 261 ? 8.39076   -19.12984 27.73413 1.000 56.09092 ? 262 LEU A CD1 1 
ATOM   1956 C CD2 . LEU A 1 261 ? 6.66960   -18.90375 25.90825 1.000 53.45748 ? 262 LEU A CD2 1 
ATOM   1957 N N   . ASP A 1 262 ? 10.88074  -18.15535 22.53730 1.000 54.48078 ? 263 ASP A N   1 
ATOM   1958 C CA  . ASP A 1 262 ? 11.44515  -17.39846 21.41998 1.000 57.04983 ? 263 ASP A CA  1 
ATOM   1959 C C   . ASP A 1 262 ? 10.68018  -17.69159 20.13040 1.000 52.79647 ? 263 ASP A C   1 
ATOM   1960 O O   . ASP A 1 262 ? 10.20070  -16.77225 19.45256 1.000 53.05199 ? 263 ASP A O   1 
ATOM   1961 C CB  . ASP A 1 262 ? 12.93728  -17.71521 21.24610 1.000 57.50960 ? 263 ASP A CB  1 
ATOM   1962 C CG  . ASP A 1 262 ? 13.83207  -17.02424 22.28627 1.000 60.91877 ? 263 ASP A CG  1 
ATOM   1963 O OD1 . ASP A 1 262 ? 13.36978  -16.07296 22.94886 1.000 62.78664 ? 263 ASP A OD1 1 
ATOM   1964 O OD2 . ASP A 1 262 ? 15.01559  -17.42858 22.41918 1.000 58.26436 ? 263 ASP A OD2 1 
ATOM   1965 N N   . MET A 1 263 ? 10.51691  -18.97351 19.79173 1.000 48.37313 ? 264 MET A N   1 
ATOM   1966 C CA  . MET A 1 263 ? 9.71182   -19.29689 18.61639 1.000 49.51136 ? 264 MET A CA  1 
ATOM   1967 C C   . MET A 1 263 ? 8.30735   -18.70026 18.69987 1.000 50.07094 ? 264 MET A C   1 
ATOM   1968 O O   . MET A 1 263 ? 7.74458   -18.30683 17.67059 1.000 48.22109 ? 264 MET A O   1 
ATOM   1969 C CB  . MET A 1 263 ? 9.63307   -20.80540 18.40743 1.000 45.18711 ? 264 MET A CB  1 
ATOM   1970 C CG  . MET A 1 263 ? 9.10840   -21.15059 17.02210 1.000 48.15353 ? 264 MET A CG  1 
ATOM   1971 S SD  . MET A 1 263 ? 10.26568  -20.63213 15.68665 1.000 46.73648 ? 264 MET A SD  1 
ATOM   1972 C CE  . MET A 1 263 ? 11.39119  -22.02118 15.72928 1.000 39.67652 ? 264 MET A CE  1 
ATOM   1973 N N   . CYS A 1 264 ? 7.73974   -18.59073 19.91106 1.000 46.74344 ? 265 CYS A N   1 
ATOM   1974 C CA  . CYS A 1 264 ? 6.41976   -17.99420 20.04674 1.000 47.20195 ? 265 CYS A CA  1 
ATOM   1975 C C   . CYS A 1 264 ? 6.44153   -16.50226 19.74784 1.000 48.33503 ? 265 CYS A C   1 
ATOM   1976 O O   . CYS A 1 264 ? 5.50952   -15.97687 19.12339 1.000 49.97767 ? 265 CYS A O   1 
ATOM   1977 C CB  . CYS A 1 264 ? 5.86480   -18.24789 21.45089 1.000 56.59650 ? 265 CYS A CB  1 
ATOM   1978 S SG  . CYS A 1 264 ? 5.43741   -19.97465 21.79947 1.000 55.38758 ? 265 CYS A SG  1 
ATOM   1979 N N   . ALA A 1 265 ? 7.47229   -15.79034 20.21872 1.000 54.31292 ? 266 ALA A N   1 
ATOM   1980 C CA  . ALA A 1 265 ? 7.62573   -14.38856 19.83185 1.000 52.00849 ? 266 ALA A CA  1 
ATOM   1981 C C   . ALA A 1 265 ? 7.77136   -14.25543 18.32139 1.000 49.49075 ? 266 ALA A C   1 
ATOM   1982 O O   . ALA A 1 265 ? 7.24149   -13.31754 17.71737 1.000 54.50382 ? 266 ALA A O   1 
ATOM   1983 C CB  . ALA A 1 265 ? 8.82990   -13.77128 20.54126 1.000 58.88697 ? 266 ALA A CB  1 
ATOM   1984 N N   . ALA A 1 266 ? 8.47974   -15.19772 17.69464 1.000 50.26125 ? 267 ALA A N   1 
ATOM   1985 C CA  . ALA A 1 266 ? 8.56702   -15.22809 16.23620 1.000 51.01272 ? 267 ALA A CA  1 
ATOM   1986 C C   . ALA A 1 266 ? 7.18631   -15.36507 15.60023 1.000 55.24351 ? 267 ALA A C   1 
ATOM   1987 O O   . ALA A 1 266 ? 6.78881   -14.53508 14.77268 1.000 54.94895 ? 267 ALA A O   1 
ATOM   1988 C CB  . ALA A 1 266 ? 9.48129   -16.37063 15.80348 1.000 48.96027 ? 267 ALA A CB  1 
ATOM   1989 N N   . LEU A 1 267 ? 6.43024   -16.40452 15.99294 1.000 52.91282 ? 268 LEU A N   1 
ATOM   1990 C CA  . LEU A 1 267 ? 5.08326   -16.60037 15.45555 1.000 49.70873 ? 268 LEU A CA  1 
ATOM   1991 C C   . LEU A 1 267 ? 4.19545   -15.38592 15.70453 1.000 51.22887 ? 268 LEU A C   1 
ATOM   1992 O O   . LEU A 1 267 ? 3.46741   -14.95026 14.80507 1.000 54.18913 ? 268 LEU A O   1 
ATOM   1993 C CB  . LEU A 1 267 ? 4.45546   -17.85625 16.06069 1.000 51.68367 ? 268 LEU A CB  1 
ATOM   1994 C CG  . LEU A 1 267 ? 2.93960   -18.02907 15.95786 1.000 54.01565 ? 268 LEU A CG  1 
ATOM   1995 C CD1 . LEU A 1 267 ? 2.46637   -18.01982 14.50238 1.000 51.18241 ? 268 LEU A CD1 1 
ATOM   1996 C CD2 . LEU A 1 267 ? 2.52931   -19.32431 16.64795 1.000 50.75376 ? 268 LEU A CD2 1 
ATOM   1997 N N   . LYS A 1 268 ? 4.24235   -14.81659 16.91185 1.000 50.37494 ? 269 LYS A N   1 
ATOM   1998 C CA  . LYS A 1 268 ? 3.41761   -13.64068 17.18403 1.000 55.05672 ? 269 LYS A CA  1 
ATOM   1999 C C   . LYS A 1 268 ? 3.70340   -12.52769 16.18278 1.000 59.13748 ? 269 LYS A C   1 
ATOM   2000 O O   . LYS A 1 268 ? 2.77298   -11.89917 15.66830 1.000 60.04251 ? 269 LYS A O   1 
ATOM   2001 C CB  . LYS A 1 268 ? 3.63761   -13.14819 18.61665 1.000 56.36211 ? 269 LYS A CB  1 
ATOM   2002 N N   . GLU A 1 269 ? 4.98800   -12.29705 15.86510 1.000 56.01021 ? 270 GLU A N   1 
ATOM   2003 C CA  . GLU A 1 269 ? 5.34732   -11.30572 14.85048 1.000 60.01457 ? 270 GLU A CA  1 
ATOM   2004 C C   . GLU A 1 269 ? 4.79357   -11.67921 13.47613 1.000 59.61240 ? 270 GLU A C   1 
ATOM   2005 O O   . GLU A 1 269 ? 4.33784   -10.80693 12.72540 1.000 60.20161 ? 270 GLU A O   1 
ATOM   2006 C CB  . GLU A 1 269 ? 6.87049   -11.13711 14.78347 1.000 56.05867 ? 270 GLU A CB  1 
ATOM   2007 N N   . LEU A 1 270 ? 4.83176   -12.96672 13.12033 1.000 56.52174 ? 271 LEU A N   1 
ATOM   2008 C CA  . LEU A 1 270 ? 4.24262   -13.38171 11.85011 1.000 56.12455 ? 271 LEU A CA  1 
ATOM   2009 C C   . LEU A 1 270 ? 2.75574   -13.06621 11.80842 1.000 64.33347 ? 271 LEU A C   1 
ATOM   2010 O O   . LEU A 1 270 ? 2.24691   -12.57586 10.79364 1.000 69.42655 ? 271 LEU A O   1 
ATOM   2011 C CB  . LEU A 1 270 ? 4.49131   -14.86905 11.61207 1.000 55.59095 ? 271 LEU A CB  1 
ATOM   2012 C CG  . LEU A 1 270 ? 5.91502   -15.19033 11.17512 1.000 55.06429 ? 271 LEU A CG  1 
ATOM   2013 C CD1 . LEU A 1 270 ? 6.16766   -16.68200 11.04796 1.000 51.64222 ? 271 LEU A CD1 1 
ATOM   2014 C CD2 . LEU A 1 270 ? 6.16142   -14.50455 9.84543  1.000 66.09310 ? 271 LEU A CD2 1 
ATOM   2015 N N   . LEU A 1 271 ? 2.04443   -13.31037 12.91507 1.000 63.14548 ? 272 LEU A N   1 
ATOM   2016 C CA  . LEU A 1 271 ? 0.60501   -13.08648 12.92503 1.000 61.11435 ? 272 LEU A CA  1 
ATOM   2017 C C   . LEU A 1 271 ? 0.25975   -11.60706 12.84301 1.000 65.19404 ? 272 LEU A C   1 
ATOM   2018 O O   . LEU A 1 271 ? -0.77473  -11.24304 12.27440 1.000 70.06381 ? 272 LEU A O   1 
ATOM   2019 C CB  . LEU A 1 271 ? -0.00963  -13.69422 14.18309 1.000 63.17923 ? 272 LEU A CB  1 
ATOM   2020 C CG  . LEU A 1 271 ? 0.19971   -15.18953 14.38873 1.000 56.49668 ? 272 LEU A CG  1 
ATOM   2021 C CD1 . LEU A 1 271 ? -0.52948  -15.64055 15.62984 1.000 55.88575 ? 272 LEU A CD1 1 
ATOM   2022 C CD2 . LEU A 1 271 ? -0.29991  -15.94029 13.18460 1.000 60.03116 ? 272 LEU A CD2 1 
ATOM   2023 N N   . GLN A 1 272 ? 1.09088   -10.74471 13.41721 1.000 67.14940 ? 273 GLN A N   1 
ATOM   2024 C CA  . GLN A 1 272 ? 0.77573   -9.32157  13.46535 1.000 70.46698 ? 273 GLN A CA  1 
ATOM   2025 C C   . GLN A 1 272 ? 1.24211   -8.55969  12.22880 1.000 71.04723 ? 273 GLN A C   1 
ATOM   2026 O O   . GLN A 1 272 ? 0.63218   -7.54516  11.87303 1.000 74.87380 ? 273 GLN A O   1 
ATOM   2027 C CB  . GLN A 1 272 ? 1.38701   -8.69920  14.72509 1.000 69.56384 ? 273 GLN A CB  1 
ATOM   2028 C CG  . GLN A 1 272 ? 1.09591   -9.50457  15.98355 1.000 70.88616 ? 273 GLN A CG  1 
ATOM   2029 C CD  . GLN A 1 272 ? 1.54756   -8.81760  17.24905 1.000 68.43123 ? 273 GLN A CD  1 
ATOM   2030 O OE1 . GLN A 1 272 ? 0.73798   -8.51741  18.12599 1.000 67.92120 ? 273 GLN A OE1 1 
ATOM   2031 N NE2 . GLN A 1 272 ? 2.84503   -8.56090  17.35130 1.000 67.80653 ? 273 GLN A NE2 1 
ATOM   2032 N N   . ASN A 1 273 ? 2.29164   -9.02387  11.55270 1.000 67.96246 ? 274 ASN A N   1 
ATOM   2033 C CA  . ASN A 1 273 ? 2.86295   -8.29054  10.42707 1.000 74.07108 ? 274 ASN A CA  1 
ATOM   2034 C C   . ASN A 1 273 ? 2.80065   -9.06318  9.11165  1.000 75.45750 ? 274 ASN A C   1 
ATOM   2035 O O   . ASN A 1 273 ? 3.46677   -8.67470  8.14531  1.000 76.48748 ? 274 ASN A O   1 
ATOM   2036 C CB  . ASN A 1 273 ? 4.31176   -7.89432  10.73808 1.000 67.92237 ? 274 ASN A CB  1 
ATOM   2037 N N   . GLY A 1 274 ? 2.01603   -10.13395 9.04020  1.000 75.35138 ? 275 GLY A N   1 
ATOM   2038 C CA  . GLY A 1 274 ? 1.89969   -10.90190 7.81651  1.000 75.43997 ? 275 GLY A CA  1 
ATOM   2039 C C   . GLY A 1 274 ? 3.20881   -11.50863 7.36157  1.000 75.79722 ? 275 GLY A C   1 
ATOM   2040 O O   . GLY A 1 274 ? 4.21955   -11.41386 8.06087  1.000 76.44297 ? 275 GLY A O   1 
ATOM   2041 N N   . MET A 1 275 ? 3.20963   -12.14561 6.19472  1.000 79.27167 ? 276 MET A N   1 
ATOM   2042 C CA  . MET A 1 275 ? 4.44243   -12.67656 5.63283  1.000 83.29576 ? 276 MET A CA  1 
ATOM   2043 C C   . MET A 1 275 ? 5.02541   -11.78433 4.54214  1.000 86.88768 ? 276 MET A C   1 
ATOM   2044 O O   . MET A 1 275 ? 6.15338   -12.03671 4.09519  1.000 85.49840 ? 276 MET A O   1 
ATOM   2045 C CB  . MET A 1 275 ? 4.20919   -14.09786 5.10465  1.000 81.40584 ? 276 MET A CB  1 
ATOM   2046 C CG  . MET A 1 275 ? 3.98708   -15.09200 6.23564  1.000 80.78228 ? 276 MET A CG  1 
ATOM   2047 S SD  . MET A 1 275 ? 4.07020   -16.82330 5.75923  1.000 90.90645 ? 276 MET A SD  1 
ATOM   2048 C CE  . MET A 1 275 ? 5.54988   -16.82995 4.75945  1.000 80.20464 ? 276 MET A CE  1 
ATOM   2049 N N   . ASN A 1 276 ? 4.29225   -10.73841 4.13692  1.000 87.97343 ? 277 ASN A N   1 
ATOM   2050 C CA  . ASN A 1 276 ? 4.74398   -9.70843  3.20516  1.000 89.37224 ? 277 ASN A CA  1 
ATOM   2051 C C   . ASN A 1 276 ? 5.44713   -10.30531 1.99221  1.000 91.22315 ? 277 ASN A C   1 
ATOM   2052 O O   . ASN A 1 276 ? 6.49515   -9.80856  1.56889  1.000 89.68301 ? 277 ASN A O   1 
ATOM   2053 C CB  . ASN A 1 276 ? 5.66206   -8.70917  3.91636  1.000 89.59658 ? 277 ASN A CB  1 
ATOM   2054 N N   . GLY A 1 277 ? 4.89215   -11.38520 1.44277  1.000 91.36321 ? 278 GLY A N   1 
ATOM   2055 C CA  . GLY A 1 277 ? 5.37953   -11.94009 0.19909  1.000 89.37539 ? 278 GLY A CA  1 
ATOM   2056 C C   . GLY A 1 277 ? 6.41394   -13.03880 0.31407  1.000 86.58920 ? 278 GLY A C   1 
ATOM   2057 O O   . GLY A 1 277 ? 6.78351   -13.62124 -0.71263 1.000 88.85423 ? 278 GLY A O   1 
ATOM   2058 N N   . ARG A 1 278 ? 6.89608   -13.34980 1.51301  1.000 84.95818 ? 279 ARG A N   1 
ATOM   2059 C CA  . ARG A 1 278 ? 7.88467   -14.40673 1.64973  1.000 82.37006 ? 279 ARG A CA  1 
ATOM   2060 C C   . ARG A 1 278 ? 7.19914   -15.76595 1.80273  1.000 79.22076 ? 279 ARG A C   1 
ATOM   2061 O O   . ARG A 1 278 ? 5.97547   -15.87687 1.88506  1.000 76.49733 ? 279 ARG A O   1 
ATOM   2062 C CB  . ARG A 1 278 ? 8.82005   -14.11518 2.82144  1.000 81.66902 ? 279 ARG A CB  1 
ATOM   2063 N N   . THR A 1 279 ? 8.00513   -16.82102 1.82306  1.000 80.37036 ? 280 THR A N   1 
ATOM   2064 C CA  . THR A 1 279 ? 7.51287   -18.18844 1.87678  1.000 78.02997 ? 280 THR A CA  1 
ATOM   2065 C C   . THR A 1 279 ? 8.25587   -18.95519 2.95813  1.000 78.54183 ? 280 THR A C   1 
ATOM   2066 O O   . THR A 1 279 ? 9.47185   -18.79947 3.11867  1.000 77.30532 ? 280 THR A O   1 
ATOM   2067 C CB  . THR A 1 279 ? 7.71050   -18.93192 0.54523  1.000 77.84926 ? 280 THR A CB  1 
ATOM   2068 O OG1 . THR A 1 279 ? 9.00259   -19.55556 0.54528  1.000 74.31035 ? 280 THR A OG1 1 
ATOM   2069 C CG2 . THR A 1 279 ? 7.62333   -17.97556 -0.63712 1.000 78.91064 ? 280 THR A CG2 1 
ATOM   2070 N N   . ILE A 1 280 ? 7.53034   -19.80910 3.67417  1.000 74.22819 ? 281 ILE A N   1 
ATOM   2071 C CA  . ILE A 1 280 ? 8.12328   -20.71220 4.65234  1.000 72.90659 ? 281 ILE A CA  1 
ATOM   2072 C C   . ILE A 1 280 ? 7.94450   -22.13018 4.13679  1.000 72.32515 ? 281 ILE A C   1 
ATOM   2073 O O   . ILE A 1 280 ? 6.82060   -22.54623 3.83507  1.000 75.14397 ? 281 ILE A O   1 
ATOM   2074 C CB  . ILE A 1 280 ? 7.49014   -20.54739 6.04194  1.000 68.31076 ? 281 ILE A CB  1 
ATOM   2075 C CG1 . ILE A 1 280 ? 7.49696   -19.08055 6.47143  1.000 68.79096 ? 281 ILE A CG1 1 
ATOM   2076 C CG2 . ILE A 1 280 ? 8.23865   -21.38241 7.04662  1.000 65.89849 ? 281 ILE A CG2 1 
ATOM   2077 C CD1 . ILE A 1 280 ? 7.31240   -18.87375 7.96000  1.000 65.99521 ? 281 ILE A CD1 1 
ATOM   2078 N N   . LEU A 1 281 ? 9.04742   -22.86719 4.02132  1.000 70.77793 ? 282 LEU A N   1 
ATOM   2079 C CA  . LEU A 1 281 ? 9.01374   -24.25799 3.56623  1.000 70.43200 ? 282 LEU A CA  1 
ATOM   2080 C C   . LEU A 1 281 ? 8.17912   -24.42753 2.30119  1.000 74.43117 ? 282 LEU A C   1 
ATOM   2081 O O   . LEU A 1 281 ? 7.55387   -25.46973 2.09086  1.000 71.28928 ? 282 LEU A O   1 
ATOM   2082 C CB  . LEU A 1 281 ? 8.48740   -25.17537 4.66235  1.000 70.55577 ? 282 LEU A CB  1 
ATOM   2083 C CG  . LEU A 1 281 ? 9.52423   -25.62444 5.67569  1.000 68.92536 ? 282 LEU A CG  1 
ATOM   2084 C CD1 . LEU A 1 281 ? 8.82807   -26.22753 6.87704  1.000 65.11203 ? 282 LEU A CD1 1 
ATOM   2085 C CD2 . LEU A 1 281 ? 10.46544  -26.62424 5.04362  1.000 66.71034 ? 282 LEU A CD2 1 
ATOM   2086 N N   . GLY A 1 282 ? 8.15434   -23.39709 1.45715  1.000 76.09084 ? 283 GLY A N   1 
ATOM   2087 C CA  . GLY A 1 282 ? 7.38628   -23.41942 0.23615  1.000 76.17370 ? 283 GLY A CA  1 
ATOM   2088 C C   . GLY A 1 282 ? 5.97323   -22.90110 0.36063  1.000 75.22697 ? 283 GLY A C   1 
ATOM   2089 O O   . GLY A 1 282 ? 5.27760   -22.79068 -0.65656 1.000 79.23630 ? 283 GLY A O   1 
ATOM   2090 N N   . SER A 1 283 ? 5.52261   -22.57276 1.56236  1.000 75.64104 ? 284 SER A N   1 
ATOM   2091 C CA  . SER A 1 283 ? 4.15012   -22.14242 1.77859  1.000 77.22845 ? 284 SER A CA  1 
ATOM   2092 C C   . SER A 1 283 ? 4.10522   -20.64031 2.03842  1.000 76.50666 ? 284 SER A C   1 
ATOM   2093 O O   . SER A 1 283 ? 5.06908   -20.04869 2.53657  1.000 74.21736 ? 284 SER A O   1 
ATOM   2094 C CB  . SER A 1 283 ? 3.51520   -22.90858 2.95143  1.000 72.93911 ? 284 SER A CB  1 
ATOM   2095 O OG  . SER A 1 283 ? 2.12010   -23.07848 2.77108  1.000 74.85938 ? 284 SER A OG  1 
ATOM   2096 N N   . THR A 1 284 ? 2.97559   -20.02934 1.68035  1.000 71.69161 ? 285 THR A N   1 
ATOM   2097 C CA  . THR A 1 284 ? 2.69816   -18.62989 1.97581  1.000 75.12379 ? 285 THR A CA  1 
ATOM   2098 C C   . THR A 1 284 ? 1.66486   -18.47363 3.08655  1.000 77.89558 ? 285 THR A C   1 
ATOM   2099 O O   . THR A 1 284 ? 1.23399   -17.35066 3.37540  1.000 80.21812 ? 285 THR A O   1 
ATOM   2100 C CB  . THR A 1 284 ? 2.22619   -17.91142 0.71218  1.000 79.47927 ? 285 THR A CB  1 
ATOM   2101 O OG1 . THR A 1 284 ? 1.02291   -18.53098 0.23953  1.000 76.77147 ? 285 THR A OG1 1 
ATOM   2102 C CG2 . THR A 1 284 ? 3.30138   -17.99474 -0.38317 1.000 76.98707 ? 285 THR A CG2 1 
ATOM   2103 N N   . ILE A 1 285 ? 1.24808   -19.57940 3.70324  1.000 76.39225 ? 286 ILE A N   1 
ATOM   2104 C CA  . ILE A 1 285 ? 0.34795   -19.57901 4.84729  1.000 74.45121 ? 286 ILE A CA  1 
ATOM   2105 C C   . ILE A 1 285 ? 1.01113   -20.37729 5.96340  1.000 70.21665 ? 286 ILE A C   1 
ATOM   2106 O O   . ILE A 1 285 ? 2.04204   -21.02274 5.76865  1.000 72.63081 ? 286 ILE A O   1 
ATOM   2107 C CB  . ILE A 1 285 ? -1.03248  -20.16855 4.50440  1.000 77.68216 ? 286 ILE A CB  1 
ATOM   2108 C CG1 . ILE A 1 285 ? -0.86443  -21.44156 3.66567  1.000 76.28011 ? 286 ILE A CG1 1 
ATOM   2109 C CG2 . ILE A 1 285 ? -1.90403  -19.12721 3.79495  1.000 75.88025 ? 286 ILE A CG2 1 
ATOM   2110 C CD1 . ILE A 1 285 ? -0.69583  -22.70630 4.48432  1.000 71.78439 ? 286 ILE A CD1 1 
ATOM   2111 N N   . LEU A 1 286 ? 0.40470   -20.33450 7.14193  1.000 67.38070 ? 287 LEU A N   1 
ATOM   2112 C CA  . LEU A 1 286 ? 0.96647   -21.01260 8.30463  1.000 65.12947 ? 287 LEU A CA  1 
ATOM   2113 C C   . LEU A 1 286 ? 0.32897   -22.39812 8.42041  1.000 61.50395 ? 287 LEU A C   1 
ATOM   2114 O O   . LEU A 1 286 ? -0.83440  -22.52782 8.81473  1.000 64.38613 ? 287 LEU A O   1 
ATOM   2115 C CB  . LEU A 1 286 ? 0.77451   -20.15699 9.55780  1.000 60.01669 ? 287 LEU A CB  1 
ATOM   2116 C CG  . LEU A 1 286 ? 1.67130   -18.90353 9.52531  1.000 59.77471 ? 287 LEU A CG  1 
ATOM   2117 C CD1 . LEU A 1 286 ? 1.41115   -17.93186 10.66269 1.000 51.86009 ? 287 LEU A CD1 1 
ATOM   2118 C CD2 . LEU A 1 286 ? 3.15142   -19.29201 9.49658  1.000 66.32133 ? 287 LEU A CD2 1 
ATOM   2119 N N   . GLU A 1 287 ? 1.09757   -23.42782 8.06933  1.000 59.02296 ? 288 GLU A N   1 
ATOM   2120 C CA  . GLU A 1 287 ? 0.60937   -24.80430 8.06198  1.000 61.05951 ? 288 GLU A CA  1 
ATOM   2121 C C   . GLU A 1 287 ? 0.35104   -25.29702 9.47905  1.000 56.96337 ? 288 GLU A C   1 
ATOM   2122 O O   . GLU A 1 287 ? 1.21389   -25.16659 10.35847 1.000 55.56487 ? 288 GLU A O   1 
ATOM   2123 C CB  . GLU A 1 287 ? 1.63417   -25.73544 7.40559  1.000 60.96836 ? 288 GLU A CB  1 
ATOM   2124 C CG  . GLU A 1 287 ? 1.94819   -25.45431 5.94763  1.000 66.10622 ? 288 GLU A CG  1 
ATOM   2125 C CD  . GLU A 1 287 ? 1.01178   -26.16176 4.98251  1.000 73.29591 ? 288 GLU A CD  1 
ATOM   2126 O OE1 . GLU A 1 287 ? 0.06731   -26.85145 5.44739  1.000 71.15385 ? 288 GLU A OE1 1 
ATOM   2127 O OE2 . GLU A 1 287 ? 1.24393   -26.03505 3.75531  1.000 70.44940 ? 288 GLU A OE2 1 
ATOM   2128 N N   . ASP A 1 288 ? -0.81285  -25.92214 9.69607  1.000 51.24090 ? 289 ASP A N   1 
ATOM   2129 C CA  . ASP A 1 288 ? -1.08027  -26.48864 11.01248 1.000 47.93149 ? 289 ASP A CA  1 
ATOM   2130 C C   . ASP A 1 288 ? -1.46801  -27.97098 10.97084 1.000 46.70871 ? 289 ASP A C   1 
ATOM   2131 O O   . ASP A 1 288 ? -2.06880  -28.46311 11.92319 1.000 46.03409 ? 289 ASP A O   1 
ATOM   2132 C CB  . ASP A 1 288 ? -2.13467  -25.64746 11.74633 1.000 44.13476 ? 289 ASP A CB  1 
ATOM   2133 C CG  . ASP A 1 288 ? -3.55694  -25.90781 11.26727 1.000 46.64040 ? 289 ASP A CG  1 
ATOM   2134 O OD1 . ASP A 1 288 ? -3.74009  -26.58017 10.24112 1.000 48.77277 ? 289 ASP A OD1 1 
ATOM   2135 O OD2 . ASP A 1 288 ? -4.50486  -25.40426 11.91415 1.000 47.11792 ? 289 ASP A OD2 1 
ATOM   2136 N N   . GLU A 1 289 ? -1.09317  -28.71547 9.92551  1.000 47.12719 ? 290 GLU A N   1 
ATOM   2137 C CA  . GLU A 1 289 ? -1.39620  -30.14454 9.86418  1.000 50.18186 ? 290 GLU A CA  1 
ATOM   2138 C C   . GLU A 1 289 ? -0.13323  -31.01345 9.87758  1.000 52.64644 ? 290 GLU A C   1 
ATOM   2139 O O   . GLU A 1 289 ? -0.15715  -32.16022 9.41023  1.000 47.08867 ? 290 GLU A O   1 
ATOM   2140 C CB  . GLU A 1 289 ? -2.28741  -30.45722 8.65179  1.000 46.21443 ? 290 GLU A CB  1 
ATOM   2141 C CG  . GLU A 1 289 ? -3.67850  -29.76200 8.71049  1.000 44.29897 ? 290 GLU A CG  1 
ATOM   2142 C CD  . GLU A 1 289 ? -4.86696  -30.62448 8.22596  1.000 52.09155 ? 290 GLU A CD  1 
ATOM   2143 O OE1 . GLU A 1 289 ? -4.64614  -31.66353 7.54301  1.000 49.60089 ? 290 GLU A OE1 1 
ATOM   2144 O OE2 . GLU A 1 289 ? -6.03378  -30.23743 8.52182  1.000 42.95876 ? 290 GLU A OE2 1 
ATOM   2145 N N   . PHE A 1 290 ? 0.95899   -30.50927 10.44879 1.000 45.75461 ? 291 PHE A N   1 
ATOM   2146 C CA  . PHE A 1 290 ? 2.10051   -31.33800 10.80711 1.000 48.19412 ? 291 PHE A CA  1 
ATOM   2147 C C   . PHE A 1 290 ? 2.28233   -31.28983 12.31330 1.000 49.36596 ? 291 PHE A C   1 
ATOM   2148 O O   . PHE A 1 290 ? 2.31215   -30.20548 12.89795 1.000 49.79803 ? 291 PHE A O   1 
ATOM   2149 C CB  . PHE A 1 290 ? 3.39480   -30.86766 10.14085 1.000 53.79893 ? 291 PHE A CB  1 
ATOM   2150 C CG  . PHE A 1 290 ? 3.36112   -30.85378 8.64419  1.000 53.56346 ? 291 PHE A CG  1 
ATOM   2151 C CD1 . PHE A 1 290 ? 2.90743   -29.73471 7.95123  1.000 53.02236 ? 291 PHE A CD1 1 
ATOM   2152 C CD2 . PHE A 1 290 ? 3.85078   -31.93858 7.92060  1.000 55.67697 ? 291 PHE A CD2 1 
ATOM   2153 C CE1 . PHE A 1 290 ? 2.91942   -29.70613 6.54859  1.000 54.23988 ? 291 PHE A CE1 1 
ATOM   2154 C CE2 . PHE A 1 290 ? 3.86363   -31.92380 6.52725  1.000 54.83982 ? 291 PHE A CE2 1 
ATOM   2155 C CZ  . PHE A 1 290 ? 3.39513   -30.80444 5.84055  1.000 56.37597 ? 291 PHE A CZ  1 
ATOM   2156 N N   . THR A 1 291 ? 2.41397   -32.45283 12.93530 1.000 49.70564 ? 292 THR A N   1 
ATOM   2157 C CA  . THR A 1 291 ? 2.62578   -32.52135 14.37245 1.000 47.48235 ? 292 THR A CA  1 
ATOM   2158 C C   . THR A 1 291 ? 4.11328   -32.39688 14.70027 1.000 53.46254 ? 292 THR A C   1 
ATOM   2159 O O   . THR A 1 291 ? 4.97388   -32.41687 13.81690 1.000 48.64644 ? 292 THR A O   1 
ATOM   2160 C CB  . THR A 1 291 ? 2.06484   -33.83058 14.91898 1.000 50.49820 ? 292 THR A CB  1 
ATOM   2161 O OG1 . THR A 1 291 ? 2.62436   -34.93022 14.19021 1.000 48.07155 ? 292 THR A OG1 1 
ATOM   2162 C CG2 . THR A 1 291 ? 0.51323   -33.85973 14.82865 1.000 41.98405 ? 292 THR A CG2 1 
ATOM   2163 N N   . PRO A 1 292 ? 4.45151   -32.23302 15.98171 1.000 53.35114 ? 293 PRO A N   1 
ATOM   2164 C CA  . PRO A 1 292 ? 5.84865   -32.44033 16.37305 1.000 48.66974 ? 293 PRO A CA  1 
ATOM   2165 C C   . PRO A 1 292 ? 6.37415   -33.80571 15.96280 1.000 55.52100 ? 293 PRO A C   1 
ATOM   2166 O O   . PRO A 1 292 ? 7.52994   -33.91204 15.51538 1.000 51.71483 ? 293 PRO A O   1 
ATOM   2167 C CB  . PRO A 1 292 ? 5.80341   -32.25354 17.89552 1.000 45.52690 ? 293 PRO A CB  1 
ATOM   2168 C CG  . PRO A 1 292 ? 4.71490   -31.22075 18.07843 1.000 49.11519 ? 293 PRO A CG  1 
ATOM   2169 C CD  . PRO A 1 292 ? 3.66294   -31.60136 17.06194 1.000 48.76978 ? 293 PRO A CD  1 
ATOM   2170 N N   . PHE A 1 293 ? 5.55003   -34.85622 16.07419 1.000 52.40320 ? 294 PHE A N   1 
ATOM   2171 C CA  . PHE A 1 293 ? 5.99315   -36.17672 15.63565 1.000 51.48291 ? 294 PHE A CA  1 
ATOM   2172 C C   . PHE A 1 293 ? 6.22236   -36.21550 14.12582 1.000 54.52922 ? 294 PHE A C   1 
ATOM   2173 O O   . PHE A 1 293 ? 7.16542   -36.86069 13.65834 1.000 56.03777 ? 294 PHE A O   1 
ATOM   2174 C CB  . PHE A 1 293 ? 4.98645   -37.24860 16.05086 1.000 54.93385 ? 294 PHE A CB  1 
ATOM   2175 C CG  . PHE A 1 293 ? 5.36645   -38.64446 15.60540 1.000 61.74047 ? 294 PHE A CG  1 
ATOM   2176 C CD1 . PHE A 1 293 ? 5.08817   -39.08857 14.30845 1.000 57.18467 ? 294 PHE A CD1 1 
ATOM   2177 C CD2 . PHE A 1 293 ? 5.98856   -39.52054 16.48671 1.000 63.30279 ? 294 PHE A CD2 1 
ATOM   2178 C CE1 . PHE A 1 293 ? 5.44654   -40.36854 13.90135 1.000 57.42725 ? 294 PHE A CE1 1 
ATOM   2179 C CE2 . PHE A 1 293 ? 6.34542   -40.80675 16.08235 1.000 61.85184 ? 294 PHE A CE2 1 
ATOM   2180 C CZ  . PHE A 1 293 ? 6.07539   -41.22589 14.78947 1.000 59.41647 ? 294 PHE A CZ  1 
ATOM   2181 N N   . ASP A 1 294 ? 5.36809   -35.54810 13.34481 1.000 48.98306 ? 295 ASP A N   1 
ATOM   2182 C CA  . ASP A 1 294 ? 5.52034   -35.58802 11.89510 1.000 48.11326 ? 295 ASP A CA  1 
ATOM   2183 C C   . ASP A 1 294 ? 6.82609   -34.91792 11.46728 1.000 57.96630 ? 295 ASP A C   1 
ATOM   2184 O O   . ASP A 1 294 ? 7.53184   -35.41451 10.58398 1.000 53.32204 ? 295 ASP A O   1 
ATOM   2185 C CB  . ASP A 1 294 ? 4.33804   -34.89922 11.21076 1.000 44.78758 ? 295 ASP A CB  1 
ATOM   2186 C CG  . ASP A 1 294 ? 2.99041   -35.64234 11.41052 1.000 53.41984 ? 295 ASP A CG  1 
ATOM   2187 O OD1 . ASP A 1 294 ? 2.97045   -36.74753 12.01250 1.000 51.03763 ? 295 ASP A OD1 1 
ATOM   2188 O OD2 . ASP A 1 294 ? 1.94615   -35.08436 10.98121 1.000 48.23666 ? 295 ASP A OD2 1 
ATOM   2189 N N   . VAL A 1 295 ? 7.15134   -33.77949 12.08052 1.000 56.53659 ? 296 VAL A N   1 
ATOM   2190 C CA  . VAL A 1 295 ? 8.32030   -33.01620 11.67593 1.000 57.96049 ? 296 VAL A CA  1 
ATOM   2191 C C   . VAL A 1 295 ? 9.58724   -33.82655 11.91308 1.000 61.02612 ? 296 VAL A C   1 
ATOM   2192 O O   . VAL A 1 295 ? 10.46548  -33.91220 11.04456 1.000 58.66835 ? 296 VAL A O   1 
ATOM   2193 C CB  . VAL A 1 295 ? 8.35031   -31.67263 12.42378 1.000 56.18359 ? 296 VAL A CB  1 
ATOM   2194 C CG1 . VAL A 1 295 ? 9.72591   -31.01523 12.26213 1.000 58.16277 ? 296 VAL A CG1 1 
ATOM   2195 C CG2 . VAL A 1 295 ? 7.22858   -30.77346 11.92020 1.000 50.09269 ? 296 VAL A CG2 1 
ATOM   2196 N N   . VAL A 1 296 ? 9.68058   -34.46586 13.07721 1.000 61.36134 ? 297 VAL A N   1 
ATOM   2197 C CA  . VAL A 1 296 ? 10.83624  -35.29596 13.38369 1.000 59.51831 ? 297 VAL A CA  1 
ATOM   2198 C C   . VAL A 1 296 ? 10.93124  -36.46760 12.41073 1.000 63.00442 ? 297 VAL A C   1 
ATOM   2199 O O   . VAL A 1 296 ? 12.02531  -36.82281 11.95521 1.000 68.63874 ? 297 VAL A O   1 
ATOM   2200 C CB  . VAL A 1 296 ? 10.76404  -35.75792 14.85163 1.000 59.16216 ? 297 VAL A CB  1 
ATOM   2201 C CG1 . VAL A 1 296 ? 11.72105  -36.90503 15.10695 1.000 63.64018 ? 297 VAL A CG1 1 
ATOM   2202 C CG2 . VAL A 1 296 ? 11.05490  -34.58492 15.78711 1.000 53.41345 ? 297 VAL A CG2 1 
ATOM   2203 N N   . ARG A 1 297 ? 9.79257   -37.06981 12.04994 1.000 62.05615 ? 298 ARG A N   1 
ATOM   2204 C CA  . ARG A 1 297 ? 9.82456   -38.21044 11.13435 1.000 65.20237 ? 298 ARG A CA  1 
ATOM   2205 C C   . ARG A 1 297 ? 10.45057  -37.85384 9.79045  1.000 63.15583 ? 298 ARG A C   1 
ATOM   2206 O O   . ARG A 1 297 ? 11.07895  -38.70978 9.16078  1.000 62.77216 ? 298 ARG A O   1 
ATOM   2207 C CB  . ARG A 1 297 ? 8.41738   -38.76594 10.90952 1.000 55.00172 ? 298 ARG A CB  1 
ATOM   2208 N N   . GLN A 1 298 ? 10.28040  -36.61644 9.32952  1.000 61.70600 ? 299 GLN A N   1 
ATOM   2209 C CA  . GLN A 1 298 ? 10.76477  -36.21794 8.00757  1.000 65.68169 ? 299 GLN A CA  1 
ATOM   2210 C C   . GLN A 1 298 ? 12.19981  -35.67004 8.01152  1.000 60.78791 ? 299 GLN A C   1 
ATOM   2211 O O   . GLN A 1 298 ? 12.53868  -34.76593 8.77912  1.000 65.03810 ? 299 GLN A O   1 
ATOM   2212 C CB  . GLN A 1 298 ? 9.81682   -35.18198 7.39830  1.000 62.48645 ? 299 GLN A CB  1 
ATOM   2213 C CG  . GLN A 1 298 ? 8.77718   -35.79313 6.48820  1.000 60.99118 ? 299 GLN A CG  1 
ATOM   2214 C CD  . GLN A 1 298 ? 8.11511   -34.76841 5.57974  1.000 67.26643 ? 299 GLN A CD  1 
ATOM   2215 O OE1 . GLN A 1 298 ? 8.74970   -34.20599 4.67896  1.000 67.56782 ? 299 GLN A OE1 1 
ATOM   2216 N NE2 . GLN A 1 298 ? 6.82639   -34.51310 5.82031  1.000 60.06520 ? 299 GLN A NE2 1 
HETATM 2217 C C02 . X77 B 2 .   ? -22.84405 -41.20673 1.01318  1.000 53.15732 ? 301 X77 A C02 1 
HETATM 2218 C C04 . X77 B 2 .   ? -22.80123 -38.68609 1.59315  1.000 53.85157 ? 301 X77 A C04 1 
HETATM 2219 C C05 . X77 B 2 .   ? -23.24667 -37.72741 2.68394  1.000 51.94632 ? 301 X77 A C05 1 
HETATM 2220 C C07 . X77 B 2 .   ? -24.79082 -35.83576 3.44733  1.000 59.42070 ? 301 X77 A C07 1 
HETATM 2221 C C08 . X77 B 2 .   ? -25.68008 -34.81614 2.73341  1.000 59.58800 ? 301 X77 A C08 1 
HETATM 2222 C C09 . X77 B 2 .   ? -27.13511 -34.89963 3.17598  1.000 67.19633 ? 301 X77 A C09 1 
HETATM 2223 C C10 . X77 B 2 .   ? -27.23656 -34.77700 4.69623  1.000 68.40557 ? 301 X77 A C10 1 
HETATM 2224 C C11 . X77 B 2 .   ? -26.56123 -35.95702 5.39536  1.000 64.89840 ? 301 X77 A C11 1 
HETATM 2225 C C12 . X77 B 2 .   ? -25.46055 -36.64686 4.56826  1.000 58.43174 ? 301 X77 A C12 1 
HETATM 2226 C C14 . X77 B 2 .   ? -21.28305 -38.45252 1.49142  1.000 52.64737 ? 301 X77 A C14 1 
HETATM 2227 C C15 . X77 B 2 .   ? -20.77360 -37.52915 0.43000  1.000 52.46266 ? 301 X77 A C15 1 
HETATM 2228 C C16 . X77 B 2 .   ? -19.31001 -37.24603 0.29909  1.000 52.92159 ? 301 X77 A C16 1 
HETATM 2229 C C17 . X77 B 2 .   ? -18.35114 -37.91325 1.28035  1.000 52.39663 ? 301 X77 A C17 1 
HETATM 2230 C C19 . X77 B 2 .   ? -20.31787 -39.10831 2.46954  1.000 47.99241 ? 301 X77 A C19 1 
HETATM 2231 C C20 . X77 B 2 .   ? -24.08808 -40.28140 3.10159  1.000 54.69094 ? 301 X77 A C20 1 
HETATM 2232 C C21 . X77 B 2 .   ? -25.58691 -40.15017 2.90827  1.000 52.12745 ? 301 X77 A C21 1 
HETATM 2233 C C22 . X77 B 2 .   ? -26.52525 -40.35044 4.11013  1.000 59.04330 ? 301 X77 A C22 1 
HETATM 2234 C C23 . X77 B 2 .   ? -25.97710 -40.68696 5.50933  1.000 54.34320 ? 301 X77 A C23 1 
HETATM 2235 C C24 . X77 B 2 .   ? -27.00196 -40.85171 6.65564  1.000 50.48785 ? 301 X77 A C24 1 
HETATM 2236 C C25 . X77 B 2 .   ? -26.31018 -41.15366 7.98144  1.000 45.02962 ? 301 X77 A C25 1 
HETATM 2237 C C26 . X77 B 2 .   ? -28.00170 -41.95839 6.34666  1.000 52.36828 ? 301 X77 A C26 1 
HETATM 2238 C C27 . X77 B 2 .   ? -27.75356 -39.50142 6.74450  1.000 53.46137 ? 301 X77 A C27 1 
HETATM 2239 C C28 . X77 B 2 .   ? -24.46654 -40.81100 5.71709  1.000 47.28842 ? 301 X77 A C28 1 
HETATM 2240 C C29 . X77 B 2 .   ? -23.52743 -40.61449 4.50367  1.000 50.01364 ? 301 X77 A C29 1 
HETATM 2241 C C30 . X77 B 2 .   ? -23.27276 -42.66801 1.26995  1.000 55.66375 ? 301 X77 A C30 1 
HETATM 2242 C C31 . X77 B 2 .   ? -24.20876 -43.10450 2.16672  1.000 45.34462 ? 301 X77 A C31 1 
HETATM 2243 C C33 . X77 B 2 .   ? -23.39403 -44.81092 1.13696  1.000 58.92075 ? 301 X77 A C33 1 
HETATM 2244 N N03 . X77 B 2 .   ? -23.22059 -40.07469 1.90763  1.000 51.51941 ? 301 X77 A N03 1 
HETATM 2245 N N06 . X77 B 2 .   ? -24.33586 -36.78303 2.41008  1.000 61.27953 ? 301 X77 A N06 1 
HETATM 2246 N N18 . X77 B 2 .   ? -18.85635 -38.82372 2.33976  1.000 51.22042 ? 301 X77 A N18 1 
HETATM 2247 N N32 . X77 B 2 .   ? -24.27584 -44.40769 2.07817  1.000 55.30304 ? 301 X77 A N32 1 
HETATM 2248 N N34 . X77 B 2 .   ? -22.77919 -43.71839 0.64097  1.000 56.72206 ? 301 X77 A N34 1 
HETATM 2249 O O01 . X77 B 2 .   ? -22.16924 -41.00711 0.06579  1.000 55.89089 ? 301 X77 A O01 1 
HETATM 2250 O O13 . X77 B 2 .   ? -22.70342 -37.73695 3.73959  1.000 51.45506 ? 301 X77 A O13 1 
HETATM 2251 O O   . HOH C 3 .   ? -3.12870  -32.27422 5.91416  1.000 50.72026 ? 401 HOH A O   1 
HETATM 2252 O O   . HOH C 3 .   ? -8.19196  -32.08547 8.72213  1.000 41.69395 ? 402 HOH A O   1 
HETATM 2253 O O   . HOH C 3 .   ? -24.83210 -41.09638 16.10154 1.000 50.37783 ? 403 HOH A O   1 
HETATM 2254 O O   . HOH C 3 .   ? 1.89821   -27.59576 10.84955 1.000 49.36574 ? 404 HOH A O   1 
HETATM 2255 O O   . HOH C 3 .   ? -9.67805  -47.18646 3.85958  1.000 41.37237 ? 405 HOH A O   1 
HETATM 2256 O O   . HOH C 3 .   ? -20.83289 -27.83956 8.41870  1.000 56.98727 ? 406 HOH A O   1 
HETATM 2257 O O   . HOH C 3 .   ? 1.37107   -50.74845 4.41955  1.000 45.52844 ? 407 HOH A O   1 
HETATM 2258 O O   . HOH C 3 .   ? -23.15967 -40.00142 17.79507 1.000 42.66611 ? 408 HOH A O   1 
HETATM 2259 O O   . HOH C 3 .   ? 0.63678   -47.75713 15.37658 1.000 53.25897 ? 409 HOH A O   1 
HETATM 2260 O O   . HOH C 3 .   ? 12.68988  -32.08894 9.52395  1.000 53.10127 ? 410 HOH A O   1 
HETATM 2261 O O   . HOH C 3 .   ? -1.72181  -22.11750 29.10683 1.000 52.67365 ? 411 HOH A O   1 
HETATM 2262 O O   . HOH C 3 .   ? -17.91388 -29.12295 15.84515 1.000 47.87006 ? 412 HOH A O   1 
HETATM 2263 O O   . HOH C 3 .   ? -15.31998 -67.19405 11.93420 1.000 70.22296 ? 413 HOH A O   1 
HETATM 2264 O O   . HOH C 3 .   ? -23.31939 -45.13206 10.93068 1.000 41.87385 ? 414 HOH A O   1 
HETATM 2265 O O   . HOH C 3 .   ? -0.85047  -38.44757 15.19058 1.000 50.19834 ? 415 HOH A O   1 
HETATM 2266 O O   . HOH C 3 .   ? -30.93051 -45.30299 16.71604 1.000 46.48740 ? 416 HOH A O   1 
HETATM 2267 O O   . HOH C 3 .   ? 9.65027   -9.89017  14.11154 1.000 52.86893 ? 417 HOH A O   1 
HETATM 2268 O O   . HOH C 3 .   ? 6.22402   -36.82604 8.17482  1.000 54.64439 ? 418 HOH A O   1 
HETATM 2269 O O   . HOH C 3 .   ? -21.45284 -41.45841 18.84938 1.000 38.81962 ? 419 HOH A O   1 
HETATM 2270 O O   . HOH C 3 .   ? 14.86984  -36.95397 9.79471  1.000 66.73924 ? 420 HOH A O   1 
# 
