data_8YJP
# 
_entry.id   8YJP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YJP         pdb_00008yjp 10.2210/pdb8yjp/pdb 
WWPDB D_1300044909 ?            ?                   
EMDB  EMD-39345    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YJP 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human apo GPR156' 
_pdbx_database_related.db_id          EMD-39345 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              zhang_yan@zju.edu.cn 
_pdbx_contact_author.name_first         Renjie 
_pdbx_contact_author.name_last          Chai 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3885-543X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ma, X.Y.'    1 ? 
'Chen, L.N.'  2 ? 
'Liao, M.H.'  3 ? 
'Zhang, L.Y.' 4 ? 
'Xi, K.'      5 ? 
'Guo, J.M.'   6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                10601 
_citation.page_last                 10601 
_citation.title                     'Molecular insights into the activation mechanism of GPR156 in maintaining auditory function.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54681-5 
_citation.pdbx_database_id_PubMed   39638804 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ma, X.'     1  0000-0002-5657-1991 
primary 'Chen, L.N.' 2  ?                   
primary 'Liao, M.'   3  ?                   
primary 'Zhang, L.'  4  ?                   
primary 'Xi, K.'     5  0000-0003-1650-0002 
primary 'Guo, J.'    6  ?                   
primary 'Shen, C.'   7  ?                   
primary 'Shen, D.D.' 8  ?                   
primary 'Cai, P.'    9  ?                   
primary 'Shen, Q.'   10 0000-0001-6602-7116 
primary 'Qi, J.'     11 ?                   
primary 'Zhang, H.'  12 0000-0003-3025-0185 
primary 'Zang, S.K.' 13 ?                   
primary 'Dong, Y.J.' 14 ?                   
primary 'Miao, L.'   15 ?                   
primary 'Qin, J.'    16 ?                   
primary 'Ji, S.Y.'   17 ?                   
primary 'Li, Y.'     18 ?                   
primary 'Liu, J.'    19 0000-0002-0284-8377 
primary 'Mao, C.'    20 0000-0001-5349-8592 
primary 'Zhang, Y.'  21 0000-0003-2189-0244 
primary 'Chai, R.'   22 0000-0002-3885-543X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Probable G-protein coupled receptor 156' 38472.230 2 ? ? ? ? 
2 non-polymer syn 
'(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate' 777.060   
4 ? ? ? ? 
3 non-polymer syn CHOLESTEROL 386.654   9 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'G-protein coupled receptor PGR28,GABAB-related G-protein coupled receptor' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIV
KMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVII
KDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGA
YLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEE
ENQTIRRMAKYFSTPNKSFHTQYGEE
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIV
KMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVII
KDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGA
YLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEE
ENQTIRRMAKYFSTPNKSFHTQYGEE
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate' MW9 
3 CHOLESTEROL                                                                                                              CLR 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   PRO n 
1 4   GLU n 
1 5   ILE n 
1 6   ASN n 
1 7   CYS n 
1 8   SER n 
1 9   GLU n 
1 10  LEU n 
1 11  CYS n 
1 12  ASP n 
1 13  SER n 
1 14  PHE n 
1 15  PRO n 
1 16  GLY n 
1 17  GLN n 
1 18  GLU n 
1 19  LEU n 
1 20  ASP n 
1 21  ARG n 
1 22  ARG n 
1 23  PRO n 
1 24  LEU n 
1 25  HIS n 
1 26  ASP n 
1 27  LEU n 
1 28  CYS n 
1 29  LYS n 
1 30  THR n 
1 31  THR n 
1 32  ILE n 
1 33  THR n 
1 34  SER n 
1 35  SER n 
1 36  HIS n 
1 37  HIS n 
1 38  SER n 
1 39  SER n 
1 40  LYS n 
1 41  THR n 
1 42  ILE n 
1 43  SER n 
1 44  SER n 
1 45  LEU n 
1 46  SER n 
1 47  PRO n 
1 48  VAL n 
1 49  LEU n 
1 50  LEU n 
1 51  GLY n 
1 52  ILE n 
1 53  VAL n 
1 54  TRP n 
1 55  THR n 
1 56  PHE n 
1 57  LEU n 
1 58  SER n 
1 59  CYS n 
1 60  GLY n 
1 61  LEU n 
1 62  LEU n 
1 63  LEU n 
1 64  ILE n 
1 65  LEU n 
1 66  PHE n 
1 67  PHE n 
1 68  LEU n 
1 69  ALA n 
1 70  PHE n 
1 71  THR n 
1 72  ILE n 
1 73  HIS n 
1 74  CYS n 
1 75  ARG n 
1 76  LYS n 
1 77  ASN n 
1 78  ARG n 
1 79  ILE n 
1 80  VAL n 
1 81  LYS n 
1 82  MET n 
1 83  SER n 
1 84  SER n 
1 85  PRO n 
1 86  ASN n 
1 87  LEU n 
1 88  ASN n 
1 89  ILE n 
1 90  VAL n 
1 91  THR n 
1 92  LEU n 
1 93  LEU n 
1 94  GLY n 
1 95  SER n 
1 96  CYS n 
1 97  LEU n 
1 98  THR n 
1 99  TYR n 
1 100 SER n 
1 101 SER n 
1 102 ALA n 
1 103 TYR n 
1 104 LEU n 
1 105 PHE n 
1 106 GLY n 
1 107 ILE n 
1 108 GLN n 
1 109 ASP n 
1 110 VAL n 
1 111 LEU n 
1 112 VAL n 
1 113 GLY n 
1 114 SER n 
1 115 SER n 
1 116 MET n 
1 117 GLU n 
1 118 THR n 
1 119 LEU n 
1 120 ILE n 
1 121 GLN n 
1 122 THR n 
1 123 ARG n 
1 124 LEU n 
1 125 SER n 
1 126 MET n 
1 127 LEU n 
1 128 CYS n 
1 129 ILE n 
1 130 GLY n 
1 131 THR n 
1 132 SER n 
1 133 LEU n 
1 134 VAL n 
1 135 PHE n 
1 136 GLY n 
1 137 PRO n 
1 138 ILE n 
1 139 LEU n 
1 140 GLY n 
1 141 LYS n 
1 142 SER n 
1 143 TRP n 
1 144 ARG n 
1 145 LEU n 
1 146 TYR n 
1 147 LYS n 
1 148 VAL n 
1 149 PHE n 
1 150 THR n 
1 151 GLN n 
1 152 ARG n 
1 153 VAL n 
1 154 PRO n 
1 155 ASP n 
1 156 LYS n 
1 157 ARG n 
1 158 VAL n 
1 159 ILE n 
1 160 ILE n 
1 161 LYS n 
1 162 ASP n 
1 163 LEU n 
1 164 GLN n 
1 165 LEU n 
1 166 LEU n 
1 167 GLY n 
1 168 LEU n 
1 169 VAL n 
1 170 ALA n 
1 171 ALA n 
1 172 LEU n 
1 173 LEU n 
1 174 MET n 
1 175 ALA n 
1 176 ASP n 
1 177 VAL n 
1 178 ILE n 
1 179 LEU n 
1 180 LEU n 
1 181 MET n 
1 182 THR n 
1 183 TRP n 
1 184 VAL n 
1 185 LEU n 
1 186 THR n 
1 187 ASP n 
1 188 PRO n 
1 189 ILE n 
1 190 GLN n 
1 191 CYS n 
1 192 LEU n 
1 193 GLN n 
1 194 ILE n 
1 195 LEU n 
1 196 SER n 
1 197 VAL n 
1 198 SER n 
1 199 MET n 
1 200 THR n 
1 201 VAL n 
1 202 THR n 
1 203 GLY n 
1 204 LYS n 
1 205 ASP n 
1 206 VAL n 
1 207 SER n 
1 208 CYS n 
1 209 THR n 
1 210 SER n 
1 211 THR n 
1 212 SER n 
1 213 THR n 
1 214 HIS n 
1 215 PHE n 
1 216 CYS n 
1 217 ALA n 
1 218 SER n 
1 219 ARG n 
1 220 TYR n 
1 221 SER n 
1 222 ASP n 
1 223 VAL n 
1 224 TRP n 
1 225 ILE n 
1 226 ALA n 
1 227 LEU n 
1 228 ILE n 
1 229 TRP n 
1 230 GLY n 
1 231 CYS n 
1 232 LYS n 
1 233 GLY n 
1 234 LEU n 
1 235 LEU n 
1 236 LEU n 
1 237 LEU n 
1 238 TYR n 
1 239 GLY n 
1 240 ALA n 
1 241 TYR n 
1 242 LEU n 
1 243 ALA n 
1 244 GLY n 
1 245 LEU n 
1 246 THR n 
1 247 GLY n 
1 248 HIS n 
1 249 VAL n 
1 250 SER n 
1 251 SER n 
1 252 PRO n 
1 253 PRO n 
1 254 VAL n 
1 255 ASN n 
1 256 GLN n 
1 257 SER n 
1 258 LEU n 
1 259 THR n 
1 260 ILE n 
1 261 MET n 
1 262 VAL n 
1 263 GLY n 
1 264 VAL n 
1 265 ASN n 
1 266 LEU n 
1 267 LEU n 
1 268 VAL n 
1 269 LEU n 
1 270 ALA n 
1 271 ALA n 
1 272 GLY n 
1 273 LEU n 
1 274 LEU n 
1 275 PHE n 
1 276 VAL n 
1 277 VAL n 
1 278 THR n 
1 279 ARG n 
1 280 TYR n 
1 281 LEU n 
1 282 HIS n 
1 283 SER n 
1 284 TRP n 
1 285 PRO n 
1 286 ASN n 
1 287 LEU n 
1 288 VAL n 
1 289 PHE n 
1 290 GLY n 
1 291 LEU n 
1 292 THR n 
1 293 SER n 
1 294 GLY n 
1 295 GLY n 
1 296 ILE n 
1 297 PHE n 
1 298 VAL n 
1 299 CYS n 
1 300 THR n 
1 301 THR n 
1 302 THR n 
1 303 ILE n 
1 304 ASN n 
1 305 CYS n 
1 306 PHE n 
1 307 ILE n 
1 308 PHE n 
1 309 ILE n 
1 310 PRO n 
1 311 GLN n 
1 312 LEU n 
1 313 LYS n 
1 314 GLN n 
1 315 TRP n 
1 316 LYS n 
1 317 ALA n 
1 318 PHE n 
1 319 GLU n 
1 320 GLU n 
1 321 GLU n 
1 322 ASN n 
1 323 GLN n 
1 324 THR n 
1 325 ILE n 
1 326 ARG n 
1 327 ARG n 
1 328 MET n 
1 329 ALA n 
1 330 LYS n 
1 331 TYR n 
1 332 PHE n 
1 333 SER n 
1 334 THR n 
1 335 PRO n 
1 336 ASN n 
1 337 LYS n 
1 338 SER n 
1 339 PHE n 
1 340 HIS n 
1 341 THR n 
1 342 GLN n 
1 343 TYR n 
1 344 GLY n 
1 345 GLU n 
1 346 GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   346 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'GPR156, GABABL, PGR28' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                                                            'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                                                            'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                                            'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                                            'C4 H7 N O4'     133.103 
CLR non-polymer         . CHOLESTEROL ?                                                            'C27 H46 O'      386.654 
CYS 'L-peptide linking' y CYSTEINE ?                                                            'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                                                            'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                                            'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ?                                                            'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                                            'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE ?                                                            'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                                                            'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                                                            'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                                                            'C5 H11 N O2 S'  149.211 
MW9 non-polymer         . 
'(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate' 
"1-stearoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)" 'C42 H81 O10 P'  777.060 
PHE 'L-peptide linking' y PHENYLALANINE ?                                                            'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ?                                                            'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                                                            'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ?                                                            'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                                            'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                                                            'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                                                            'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLU 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   GLU 4   4   ?   ?   ?   A . n 
A 1 5   ILE 5   5   ?   ?   ?   A . n 
A 1 6   ASN 6   6   ?   ?   ?   A . n 
A 1 7   CYS 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   GLU 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  CYS 11  11  ?   ?   ?   A . n 
A 1 12  ASP 12  12  ?   ?   ?   A . n 
A 1 13  SER 13  13  ?   ?   ?   A . n 
A 1 14  PHE 14  14  ?   ?   ?   A . n 
A 1 15  PRO 15  15  ?   ?   ?   A . n 
A 1 16  GLY 16  16  ?   ?   ?   A . n 
A 1 17  GLN 17  17  ?   ?   ?   A . n 
A 1 18  GLU 18  18  ?   ?   ?   A . n 
A 1 19  LEU 19  19  ?   ?   ?   A . n 
A 1 20  ASP 20  20  ?   ?   ?   A . n 
A 1 21  ARG 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  22  ARG ARG A . n 
A 1 23  PRO 23  23  23  PRO PRO A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  HIS 25  25  25  HIS HIS A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  CYS 28  28  28  CYS CYS A . n 
A 1 29  LYS 29  29  29  LYS LYS A . n 
A 1 30  THR 30  30  30  THR THR A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  THR 33  33  33  THR THR A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  SER 35  35  35  SER SER A . n 
A 1 36  HIS 36  36  36  HIS HIS A . n 
A 1 37  HIS 37  37  37  HIS HIS A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  LYS 40  40  40  LYS LYS A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  ILE 42  42  42  ILE ILE A . n 
A 1 43  SER 43  43  43  SER SER A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  LEU 49  49  49  LEU LEU A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  GLY 51  51  51  GLY GLY A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  TRP 54  54  54  TRP TRP A . n 
A 1 55  THR 55  55  55  THR THR A . n 
A 1 56  PHE 56  56  56  PHE PHE A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  CYS 59  59  59  CYS CYS A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  LEU 62  62  62  LEU LEU A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  PHE 67  67  67  PHE PHE A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  ALA 69  69  69  ALA ALA A . n 
A 1 70  PHE 70  70  70  PHE PHE A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  HIS 73  73  73  HIS HIS A . n 
A 1 74  CYS 74  74  74  CYS CYS A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  LYS 81  81  81  LYS LYS A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  SER 84  84  84  SER SER A . n 
A 1 85  PRO 85  85  85  PRO PRO A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  ASN 88  88  88  ASN ASN A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  VAL 90  90  90  VAL VAL A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  GLY 94  94  94  GLY GLY A . n 
A 1 95  SER 95  95  95  SER SER A . n 
A 1 96  CYS 96  96  96  CYS CYS A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  TYR 99  99  99  TYR TYR A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 SER 101 101 101 SER SER A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 TYR 103 103 103 TYR TYR A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 GLY 106 106 106 GLY GLY A . n 
A 1 107 ILE 107 107 107 ILE ILE A . n 
A 1 108 GLN 108 108 108 GLN GLN A . n 
A 1 109 ASP 109 109 109 ASP ASP A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 SER 114 114 114 SER SER A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 MET 116 116 116 MET MET A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 THR 122 122 122 THR THR A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 SER 125 125 125 SER SER A . n 
A 1 126 MET 126 126 126 MET MET A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ILE 129 129 129 ILE ILE A . n 
A 1 130 GLY 130 130 130 GLY GLY A . n 
A 1 131 THR 131 131 131 THR THR A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 PRO 137 137 137 PRO PRO A . n 
A 1 138 ILE 138 138 138 ILE ILE A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 SER 142 142 142 SER SER A . n 
A 1 143 TRP 143 143 143 TRP TRP A . n 
A 1 144 ARG 144 144 144 ARG ARG A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 TYR 146 146 146 TYR TYR A . n 
A 1 147 LYS 147 147 147 LYS LYS A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 PHE 149 149 149 PHE PHE A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 GLN 151 151 151 GLN GLN A . n 
A 1 152 ARG 152 152 152 ARG ARG A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 PRO 154 154 154 PRO PRO A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 LYS 156 156 156 LYS LYS A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 VAL 158 158 158 VAL VAL A . n 
A 1 159 ILE 159 159 159 ILE ILE A . n 
A 1 160 ILE 160 160 160 ILE ILE A . n 
A 1 161 LYS 161 161 161 LYS LYS A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 GLN 164 164 164 GLN GLN A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 ALA 170 170 170 ALA ALA A . n 
A 1 171 ALA 171 171 171 ALA ALA A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 MET 174 174 174 MET MET A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 MET 181 181 181 MET MET A . n 
A 1 182 THR 182 182 182 THR THR A . n 
A 1 183 TRP 183 183 183 TRP TRP A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 ILE 189 189 189 ILE ILE A . n 
A 1 190 GLN 190 190 190 GLN GLN A . n 
A 1 191 CYS 191 191 191 CYS CYS A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 GLN 193 193 193 GLN GLN A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 SER 198 198 198 SER SER A . n 
A 1 199 MET 199 199 199 MET MET A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 VAL 201 201 201 VAL VAL A . n 
A 1 202 THR 202 202 202 THR THR A . n 
A 1 203 GLY 203 203 203 GLY GLY A . n 
A 1 204 LYS 204 204 204 LYS LYS A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 CYS 208 208 208 CYS CYS A . n 
A 1 209 THR 209 209 209 THR THR A . n 
A 1 210 SER 210 210 210 SER SER A . n 
A 1 211 THR 211 211 211 THR THR A . n 
A 1 212 SER 212 212 212 SER SER A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 HIS 214 214 214 HIS HIS A . n 
A 1 215 PHE 215 215 215 PHE PHE A . n 
A 1 216 CYS 216 216 216 CYS CYS A . n 
A 1 217 ALA 217 217 217 ALA ALA A . n 
A 1 218 SER 218 218 218 SER SER A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 TYR 220 220 220 TYR TYR A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 ASP 222 222 222 ASP ASP A . n 
A 1 223 VAL 223 223 223 VAL VAL A . n 
A 1 224 TRP 224 224 224 TRP TRP A . n 
A 1 225 ILE 225 225 225 ILE ILE A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 TRP 229 229 229 TRP TRP A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 CYS 231 231 231 CYS CYS A . n 
A 1 232 LYS 232 232 232 LYS LYS A . n 
A 1 233 GLY 233 233 233 GLY GLY A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 LEU 235 235 235 LEU LEU A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 TYR 238 238 238 TYR TYR A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 ALA 240 240 240 ALA ALA A . n 
A 1 241 TYR 241 241 241 TYR TYR A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 GLY 244 244 244 GLY GLY A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 THR 246 246 246 THR THR A . n 
A 1 247 GLY 247 247 247 GLY GLY A . n 
A 1 248 HIS 248 248 248 HIS HIS A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 SER 250 250 250 SER SER A . n 
A 1 251 SER 251 251 251 SER SER A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 VAL 254 254 254 VAL VAL A . n 
A 1 255 ASN 255 255 255 ASN ASN A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 LEU 258 258 258 LEU LEU A . n 
A 1 259 THR 259 259 259 THR THR A . n 
A 1 260 ILE 260 260 260 ILE ILE A . n 
A 1 261 MET 261 261 261 MET MET A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 GLY 263 263 263 GLY GLY A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ASN 265 265 265 ASN ASN A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 LEU 267 267 267 LEU LEU A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 ALA 271 271 271 ALA ALA A . n 
A 1 272 GLY 272 272 272 GLY GLY A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 PHE 275 275 275 PHE PHE A . n 
A 1 276 VAL 276 276 276 VAL VAL A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 THR 278 278 278 THR THR A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 HIS 282 282 282 HIS HIS A . n 
A 1 283 SER 283 283 283 SER SER A . n 
A 1 284 TRP 284 284 284 TRP TRP A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 ASN 286 286 286 ASN ASN A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 VAL 288 288 288 VAL VAL A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 GLY 290 290 290 GLY GLY A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 SER 293 293 293 SER SER A . n 
A 1 294 GLY 294 294 294 GLY GLY A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 ILE 296 296 296 ILE ILE A . n 
A 1 297 PHE 297 297 297 PHE PHE A . n 
A 1 298 VAL 298 298 298 VAL VAL A . n 
A 1 299 CYS 299 299 299 CYS CYS A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 THR 301 301 301 THR THR A . n 
A 1 302 THR 302 302 302 THR THR A . n 
A 1 303 ILE 303 303 303 ILE ILE A . n 
A 1 304 ASN 304 304 304 ASN ASN A . n 
A 1 305 CYS 305 305 305 CYS CYS A . n 
A 1 306 PHE 306 306 306 PHE PHE A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 PHE 308 308 308 PHE PHE A . n 
A 1 309 ILE 309 309 309 ILE ILE A . n 
A 1 310 PRO 310 310 310 PRO PRO A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 LYS 313 313 313 LYS LYS A . n 
A 1 314 GLN 314 314 314 GLN GLN A . n 
A 1 315 TRP 315 315 315 TRP TRP A . n 
A 1 316 LYS 316 316 316 LYS LYS A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 PHE 318 318 318 PHE PHE A . n 
A 1 319 GLU 319 319 319 GLU GLU A . n 
A 1 320 GLU 320 320 ?   ?   ?   A . n 
A 1 321 GLU 321 321 ?   ?   ?   A . n 
A 1 322 ASN 322 322 ?   ?   ?   A . n 
A 1 323 GLN 323 323 ?   ?   ?   A . n 
A 1 324 THR 324 324 ?   ?   ?   A . n 
A 1 325 ILE 325 325 ?   ?   ?   A . n 
A 1 326 ARG 326 326 ?   ?   ?   A . n 
A 1 327 ARG 327 327 ?   ?   ?   A . n 
A 1 328 MET 328 328 ?   ?   ?   A . n 
A 1 329 ALA 329 329 ?   ?   ?   A . n 
A 1 330 LYS 330 330 ?   ?   ?   A . n 
A 1 331 TYR 331 331 ?   ?   ?   A . n 
A 1 332 PHE 332 332 ?   ?   ?   A . n 
A 1 333 SER 333 333 ?   ?   ?   A . n 
A 1 334 THR 334 334 ?   ?   ?   A . n 
A 1 335 PRO 335 335 ?   ?   ?   A . n 
A 1 336 ASN 336 336 ?   ?   ?   A . n 
A 1 337 LYS 337 337 ?   ?   ?   A . n 
A 1 338 SER 338 338 ?   ?   ?   A . n 
A 1 339 PHE 339 339 ?   ?   ?   A . n 
A 1 340 HIS 340 340 ?   ?   ?   A . n 
A 1 341 THR 341 341 ?   ?   ?   A . n 
A 1 342 GLN 342 342 ?   ?   ?   A . n 
A 1 343 TYR 343 343 ?   ?   ?   A . n 
A 1 344 GLY 344 344 ?   ?   ?   A . n 
A 1 345 GLU 345 345 ?   ?   ?   A . n 
A 1 346 GLU 346 346 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLU 2   2   ?   ?   ?   B . n 
B 1 3   PRO 3   3   ?   ?   ?   B . n 
B 1 4   GLU 4   4   ?   ?   ?   B . n 
B 1 5   ILE 5   5   ?   ?   ?   B . n 
B 1 6   ASN 6   6   ?   ?   ?   B . n 
B 1 7   CYS 7   7   ?   ?   ?   B . n 
B 1 8   SER 8   8   ?   ?   ?   B . n 
B 1 9   GLU 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  CYS 11  11  ?   ?   ?   B . n 
B 1 12  ASP 12  12  ?   ?   ?   B . n 
B 1 13  SER 13  13  ?   ?   ?   B . n 
B 1 14  PHE 14  14  ?   ?   ?   B . n 
B 1 15  PRO 15  15  ?   ?   ?   B . n 
B 1 16  GLY 16  16  ?   ?   ?   B . n 
B 1 17  GLN 17  17  ?   ?   ?   B . n 
B 1 18  GLU 18  18  ?   ?   ?   B . n 
B 1 19  LEU 19  19  ?   ?   ?   B . n 
B 1 20  ASP 20  20  ?   ?   ?   B . n 
B 1 21  ARG 21  21  ?   ?   ?   B . n 
B 1 22  ARG 22  22  22  ARG ARG B . n 
B 1 23  PRO 23  23  23  PRO PRO B . n 
B 1 24  LEU 24  24  24  LEU LEU B . n 
B 1 25  HIS 25  25  25  HIS HIS B . n 
B 1 26  ASP 26  26  26  ASP ASP B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  CYS 28  28  28  CYS CYS B . n 
B 1 29  LYS 29  29  29  LYS LYS B . n 
B 1 30  THR 30  30  30  THR THR B . n 
B 1 31  THR 31  31  31  THR THR B . n 
B 1 32  ILE 32  32  32  ILE ILE B . n 
B 1 33  THR 33  33  33  THR THR B . n 
B 1 34  SER 34  34  34  SER SER B . n 
B 1 35  SER 35  35  35  SER SER B . n 
B 1 36  HIS 36  36  36  HIS HIS B . n 
B 1 37  HIS 37  37  37  HIS HIS B . n 
B 1 38  SER 38  38  38  SER SER B . n 
B 1 39  SER 39  39  39  SER SER B . n 
B 1 40  LYS 40  40  40  LYS LYS B . n 
B 1 41  THR 41  41  41  THR THR B . n 
B 1 42  ILE 42  42  42  ILE ILE B . n 
B 1 43  SER 43  43  43  SER SER B . n 
B 1 44  SER 44  44  44  SER SER B . n 
B 1 45  LEU 45  45  45  LEU LEU B . n 
B 1 46  SER 46  46  46  SER SER B . n 
B 1 47  PRO 47  47  47  PRO PRO B . n 
B 1 48  VAL 48  48  48  VAL VAL B . n 
B 1 49  LEU 49  49  49  LEU LEU B . n 
B 1 50  LEU 50  50  50  LEU LEU B . n 
B 1 51  GLY 51  51  51  GLY GLY B . n 
B 1 52  ILE 52  52  52  ILE ILE B . n 
B 1 53  VAL 53  53  53  VAL VAL B . n 
B 1 54  TRP 54  54  54  TRP TRP B . n 
B 1 55  THR 55  55  55  THR THR B . n 
B 1 56  PHE 56  56  56  PHE PHE B . n 
B 1 57  LEU 57  57  57  LEU LEU B . n 
B 1 58  SER 58  58  58  SER SER B . n 
B 1 59  CYS 59  59  59  CYS CYS B . n 
B 1 60  GLY 60  60  60  GLY GLY B . n 
B 1 61  LEU 61  61  61  LEU LEU B . n 
B 1 62  LEU 62  62  62  LEU LEU B . n 
B 1 63  LEU 63  63  63  LEU LEU B . n 
B 1 64  ILE 64  64  64  ILE ILE B . n 
B 1 65  LEU 65  65  65  LEU LEU B . n 
B 1 66  PHE 66  66  66  PHE PHE B . n 
B 1 67  PHE 67  67  67  PHE PHE B . n 
B 1 68  LEU 68  68  68  LEU LEU B . n 
B 1 69  ALA 69  69  69  ALA ALA B . n 
B 1 70  PHE 70  70  70  PHE PHE B . n 
B 1 71  THR 71  71  71  THR THR B . n 
B 1 72  ILE 72  72  72  ILE ILE B . n 
B 1 73  HIS 73  73  73  HIS HIS B . n 
B 1 74  CYS 74  74  74  CYS CYS B . n 
B 1 75  ARG 75  75  75  ARG ARG B . n 
B 1 76  LYS 76  76  76  LYS LYS B . n 
B 1 77  ASN 77  77  77  ASN ASN B . n 
B 1 78  ARG 78  78  78  ARG ARG B . n 
B 1 79  ILE 79  79  79  ILE ILE B . n 
B 1 80  VAL 80  80  80  VAL VAL B . n 
B 1 81  LYS 81  81  81  LYS LYS B . n 
B 1 82  MET 82  82  82  MET MET B . n 
B 1 83  SER 83  83  83  SER SER B . n 
B 1 84  SER 84  84  84  SER SER B . n 
B 1 85  PRO 85  85  85  PRO PRO B . n 
B 1 86  ASN 86  86  86  ASN ASN B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  ASN 88  88  88  ASN ASN B . n 
B 1 89  ILE 89  89  89  ILE ILE B . n 
B 1 90  VAL 90  90  90  VAL VAL B . n 
B 1 91  THR 91  91  91  THR THR B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  LEU 93  93  93  LEU LEU B . n 
B 1 94  GLY 94  94  94  GLY GLY B . n 
B 1 95  SER 95  95  95  SER SER B . n 
B 1 96  CYS 96  96  96  CYS CYS B . n 
B 1 97  LEU 97  97  97  LEU LEU B . n 
B 1 98  THR 98  98  98  THR THR B . n 
B 1 99  TYR 99  99  99  TYR TYR B . n 
B 1 100 SER 100 100 100 SER SER B . n 
B 1 101 SER 101 101 101 SER SER B . n 
B 1 102 ALA 102 102 102 ALA ALA B . n 
B 1 103 TYR 103 103 103 TYR TYR B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 PHE 105 105 105 PHE PHE B . n 
B 1 106 GLY 106 106 106 GLY GLY B . n 
B 1 107 ILE 107 107 107 ILE ILE B . n 
B 1 108 GLN 108 108 108 GLN GLN B . n 
B 1 109 ASP 109 109 109 ASP ASP B . n 
B 1 110 VAL 110 110 110 VAL VAL B . n 
B 1 111 LEU 111 111 111 LEU LEU B . n 
B 1 112 VAL 112 112 112 VAL VAL B . n 
B 1 113 GLY 113 113 113 GLY GLY B . n 
B 1 114 SER 114 114 114 SER SER B . n 
B 1 115 SER 115 115 115 SER SER B . n 
B 1 116 MET 116 116 116 MET MET B . n 
B 1 117 GLU 117 117 117 GLU GLU B . n 
B 1 118 THR 118 118 118 THR THR B . n 
B 1 119 LEU 119 119 119 LEU LEU B . n 
B 1 120 ILE 120 120 120 ILE ILE B . n 
B 1 121 GLN 121 121 121 GLN GLN B . n 
B 1 122 THR 122 122 122 THR THR B . n 
B 1 123 ARG 123 123 123 ARG ARG B . n 
B 1 124 LEU 124 124 124 LEU LEU B . n 
B 1 125 SER 125 125 125 SER SER B . n 
B 1 126 MET 126 126 126 MET MET B . n 
B 1 127 LEU 127 127 127 LEU LEU B . n 
B 1 128 CYS 128 128 128 CYS CYS B . n 
B 1 129 ILE 129 129 129 ILE ILE B . n 
B 1 130 GLY 130 130 130 GLY GLY B . n 
B 1 131 THR 131 131 131 THR THR B . n 
B 1 132 SER 132 132 132 SER SER B . n 
B 1 133 LEU 133 133 133 LEU LEU B . n 
B 1 134 VAL 134 134 134 VAL VAL B . n 
B 1 135 PHE 135 135 135 PHE PHE B . n 
B 1 136 GLY 136 136 136 GLY GLY B . n 
B 1 137 PRO 137 137 137 PRO PRO B . n 
B 1 138 ILE 138 138 138 ILE ILE B . n 
B 1 139 LEU 139 139 139 LEU LEU B . n 
B 1 140 GLY 140 140 140 GLY GLY B . n 
B 1 141 LYS 141 141 141 LYS LYS B . n 
B 1 142 SER 142 142 142 SER SER B . n 
B 1 143 TRP 143 143 143 TRP TRP B . n 
B 1 144 ARG 144 144 144 ARG ARG B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 TYR 146 146 146 TYR TYR B . n 
B 1 147 LYS 147 147 147 LYS LYS B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 PHE 149 149 149 PHE PHE B . n 
B 1 150 THR 150 150 150 THR THR B . n 
B 1 151 GLN 151 151 151 GLN GLN B . n 
B 1 152 ARG 152 152 152 ARG ARG B . n 
B 1 153 VAL 153 153 153 VAL VAL B . n 
B 1 154 PRO 154 154 154 PRO PRO B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 LYS 156 156 156 LYS LYS B . n 
B 1 157 ARG 157 157 157 ARG ARG B . n 
B 1 158 VAL 158 158 158 VAL VAL B . n 
B 1 159 ILE 159 159 159 ILE ILE B . n 
B 1 160 ILE 160 160 160 ILE ILE B . n 
B 1 161 LYS 161 161 161 LYS LYS B . n 
B 1 162 ASP 162 162 162 ASP ASP B . n 
B 1 163 LEU 163 163 163 LEU LEU B . n 
B 1 164 GLN 164 164 164 GLN GLN B . n 
B 1 165 LEU 165 165 165 LEU LEU B . n 
B 1 166 LEU 166 166 166 LEU LEU B . n 
B 1 167 GLY 167 167 167 GLY GLY B . n 
B 1 168 LEU 168 168 168 LEU LEU B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 ALA 170 170 170 ALA ALA B . n 
B 1 171 ALA 171 171 171 ALA ALA B . n 
B 1 172 LEU 172 172 172 LEU LEU B . n 
B 1 173 LEU 173 173 173 LEU LEU B . n 
B 1 174 MET 174 174 174 MET MET B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 ASP 176 176 176 ASP ASP B . n 
B 1 177 VAL 177 177 177 VAL VAL B . n 
B 1 178 ILE 178 178 178 ILE ILE B . n 
B 1 179 LEU 179 179 179 LEU LEU B . n 
B 1 180 LEU 180 180 180 LEU LEU B . n 
B 1 181 MET 181 181 181 MET MET B . n 
B 1 182 THR 182 182 182 THR THR B . n 
B 1 183 TRP 183 183 183 TRP TRP B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 LEU 185 185 185 LEU LEU B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 PRO 188 188 188 PRO PRO B . n 
B 1 189 ILE 189 189 189 ILE ILE B . n 
B 1 190 GLN 190 190 190 GLN GLN B . n 
B 1 191 CYS 191 191 191 CYS CYS B . n 
B 1 192 LEU 192 192 192 LEU LEU B . n 
B 1 193 GLN 193 193 193 GLN GLN B . n 
B 1 194 ILE 194 194 194 ILE ILE B . n 
B 1 195 LEU 195 195 195 LEU LEU B . n 
B 1 196 SER 196 196 196 SER SER B . n 
B 1 197 VAL 197 197 197 VAL VAL B . n 
B 1 198 SER 198 198 198 SER SER B . n 
B 1 199 MET 199 199 199 MET MET B . n 
B 1 200 THR 200 200 200 THR THR B . n 
B 1 201 VAL 201 201 201 VAL VAL B . n 
B 1 202 THR 202 202 202 THR THR B . n 
B 1 203 GLY 203 203 203 GLY GLY B . n 
B 1 204 LYS 204 204 204 LYS LYS B . n 
B 1 205 ASP 205 205 205 ASP ASP B . n 
B 1 206 VAL 206 206 206 VAL VAL B . n 
B 1 207 SER 207 207 207 SER SER B . n 
B 1 208 CYS 208 208 208 CYS CYS B . n 
B 1 209 THR 209 209 209 THR THR B . n 
B 1 210 SER 210 210 210 SER SER B . n 
B 1 211 THR 211 211 211 THR THR B . n 
B 1 212 SER 212 212 212 SER SER B . n 
B 1 213 THR 213 213 213 THR THR B . n 
B 1 214 HIS 214 214 214 HIS HIS B . n 
B 1 215 PHE 215 215 215 PHE PHE B . n 
B 1 216 CYS 216 216 216 CYS CYS B . n 
B 1 217 ALA 217 217 217 ALA ALA B . n 
B 1 218 SER 218 218 218 SER SER B . n 
B 1 219 ARG 219 219 219 ARG ARG B . n 
B 1 220 TYR 220 220 220 TYR TYR B . n 
B 1 221 SER 221 221 221 SER SER B . n 
B 1 222 ASP 222 222 222 ASP ASP B . n 
B 1 223 VAL 223 223 223 VAL VAL B . n 
B 1 224 TRP 224 224 224 TRP TRP B . n 
B 1 225 ILE 225 225 225 ILE ILE B . n 
B 1 226 ALA 226 226 226 ALA ALA B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 ILE 228 228 228 ILE ILE B . n 
B 1 229 TRP 229 229 229 TRP TRP B . n 
B 1 230 GLY 230 230 230 GLY GLY B . n 
B 1 231 CYS 231 231 231 CYS CYS B . n 
B 1 232 LYS 232 232 232 LYS LYS B . n 
B 1 233 GLY 233 233 233 GLY GLY B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 LEU 235 235 235 LEU LEU B . n 
B 1 236 LEU 236 236 236 LEU LEU B . n 
B 1 237 LEU 237 237 237 LEU LEU B . n 
B 1 238 TYR 238 238 238 TYR TYR B . n 
B 1 239 GLY 239 239 239 GLY GLY B . n 
B 1 240 ALA 240 240 240 ALA ALA B . n 
B 1 241 TYR 241 241 241 TYR TYR B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 ALA 243 243 243 ALA ALA B . n 
B 1 244 GLY 244 244 244 GLY GLY B . n 
B 1 245 LEU 245 245 245 LEU LEU B . n 
B 1 246 THR 246 246 246 THR THR B . n 
B 1 247 GLY 247 247 247 GLY GLY B . n 
B 1 248 HIS 248 248 248 HIS HIS B . n 
B 1 249 VAL 249 249 249 VAL VAL B . n 
B 1 250 SER 250 250 250 SER SER B . n 
B 1 251 SER 251 251 251 SER SER B . n 
B 1 252 PRO 252 252 252 PRO PRO B . n 
B 1 253 PRO 253 253 253 PRO PRO B . n 
B 1 254 VAL 254 254 254 VAL VAL B . n 
B 1 255 ASN 255 255 255 ASN ASN B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 SER 257 257 257 SER SER B . n 
B 1 258 LEU 258 258 258 LEU LEU B . n 
B 1 259 THR 259 259 259 THR THR B . n 
B 1 260 ILE 260 260 260 ILE ILE B . n 
B 1 261 MET 261 261 261 MET MET B . n 
B 1 262 VAL 262 262 262 VAL VAL B . n 
B 1 263 GLY 263 263 263 GLY GLY B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 ASN 265 265 265 ASN ASN B . n 
B 1 266 LEU 266 266 266 LEU LEU B . n 
B 1 267 LEU 267 267 267 LEU LEU B . n 
B 1 268 VAL 268 268 268 VAL VAL B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 ALA 271 271 271 ALA ALA B . n 
B 1 272 GLY 272 272 272 GLY GLY B . n 
B 1 273 LEU 273 273 273 LEU LEU B . n 
B 1 274 LEU 274 274 274 LEU LEU B . n 
B 1 275 PHE 275 275 275 PHE PHE B . n 
B 1 276 VAL 276 276 276 VAL VAL B . n 
B 1 277 VAL 277 277 277 VAL VAL B . n 
B 1 278 THR 278 278 278 THR THR B . n 
B 1 279 ARG 279 279 279 ARG ARG B . n 
B 1 280 TYR 280 280 280 TYR TYR B . n 
B 1 281 LEU 281 281 281 LEU LEU B . n 
B 1 282 HIS 282 282 282 HIS HIS B . n 
B 1 283 SER 283 283 283 SER SER B . n 
B 1 284 TRP 284 284 284 TRP TRP B . n 
B 1 285 PRO 285 285 285 PRO PRO B . n 
B 1 286 ASN 286 286 286 ASN ASN B . n 
B 1 287 LEU 287 287 287 LEU LEU B . n 
B 1 288 VAL 288 288 288 VAL VAL B . n 
B 1 289 PHE 289 289 289 PHE PHE B . n 
B 1 290 GLY 290 290 290 GLY GLY B . n 
B 1 291 LEU 291 291 291 LEU LEU B . n 
B 1 292 THR 292 292 292 THR THR B . n 
B 1 293 SER 293 293 293 SER SER B . n 
B 1 294 GLY 294 294 294 GLY GLY B . n 
B 1 295 GLY 295 295 295 GLY GLY B . n 
B 1 296 ILE 296 296 296 ILE ILE B . n 
B 1 297 PHE 297 297 297 PHE PHE B . n 
B 1 298 VAL 298 298 298 VAL VAL B . n 
B 1 299 CYS 299 299 299 CYS CYS B . n 
B 1 300 THR 300 300 300 THR THR B . n 
B 1 301 THR 301 301 301 THR THR B . n 
B 1 302 THR 302 302 302 THR THR B . n 
B 1 303 ILE 303 303 303 ILE ILE B . n 
B 1 304 ASN 304 304 304 ASN ASN B . n 
B 1 305 CYS 305 305 305 CYS CYS B . n 
B 1 306 PHE 306 306 306 PHE PHE B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 PHE 308 308 308 PHE PHE B . n 
B 1 309 ILE 309 309 309 ILE ILE B . n 
B 1 310 PRO 310 310 310 PRO PRO B . n 
B 1 311 GLN 311 311 311 GLN GLN B . n 
B 1 312 LEU 312 312 312 LEU LEU B . n 
B 1 313 LYS 313 313 313 LYS LYS B . n 
B 1 314 GLN 314 314 314 GLN GLN B . n 
B 1 315 TRP 315 315 315 TRP TRP B . n 
B 1 316 LYS 316 316 316 LYS LYS B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 PHE 318 318 318 PHE PHE B . n 
B 1 319 GLU 319 319 319 GLU GLU B . n 
B 1 320 GLU 320 320 ?   ?   ?   B . n 
B 1 321 GLU 321 321 ?   ?   ?   B . n 
B 1 322 ASN 322 322 ?   ?   ?   B . n 
B 1 323 GLN 323 323 ?   ?   ?   B . n 
B 1 324 THR 324 324 ?   ?   ?   B . n 
B 1 325 ILE 325 325 ?   ?   ?   B . n 
B 1 326 ARG 326 326 ?   ?   ?   B . n 
B 1 327 ARG 327 327 ?   ?   ?   B . n 
B 1 328 MET 328 328 ?   ?   ?   B . n 
B 1 329 ALA 329 329 ?   ?   ?   B . n 
B 1 330 LYS 330 330 ?   ?   ?   B . n 
B 1 331 TYR 331 331 ?   ?   ?   B . n 
B 1 332 PHE 332 332 ?   ?   ?   B . n 
B 1 333 SER 333 333 ?   ?   ?   B . n 
B 1 334 THR 334 334 ?   ?   ?   B . n 
B 1 335 PRO 335 335 ?   ?   ?   B . n 
B 1 336 ASN 336 336 ?   ?   ?   B . n 
B 1 337 LYS 337 337 ?   ?   ?   B . n 
B 1 338 SER 338 338 ?   ?   ?   B . n 
B 1 339 PHE 339 339 ?   ?   ?   B . n 
B 1 340 HIS 340 340 ?   ?   ?   B . n 
B 1 341 THR 341 341 ?   ?   ?   B . n 
B 1 342 GLN 342 342 ?   ?   ?   B . n 
B 1 343 TYR 343 343 ?   ?   ?   B . n 
B 1 344 GLY 344 344 ?   ?   ?   B . n 
B 1 345 GLU 345 345 ?   ?   ?   B . n 
B 1 346 GLU 346 346 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 MW9 1 401 402 MW9 LIG A . 
D 2 MW9 1 402 403 MW9 LIG A . 
E 3 CLR 1 403 405 CLR CLR A . 
F 3 CLR 1 404 408 CLR CLR A . 
G 3 CLR 1 405 404 CLR CLR A . 
H 3 CLR 1 406 406 CLR CLR A . 
I 3 CLR 1 407 408 CLR CLR A . 
J 3 CLR 1 401 406 CLR CLR B . 
K 3 CLR 1 402 407 CLR CLR B . 
L 2 MW9 1 403 402 MW9 LIG B . 
M 2 MW9 1 404 403 MW9 LIG B . 
N 3 CLR 1 405 407 CLR CLR B . 
O 3 CLR 1 406 409 CLR CLR B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ARG 22 ? CG  ? A ARG 22 CG  
2   1 Y 1 A ARG 22 ? CD  ? A ARG 22 CD  
3   1 Y 1 A ARG 22 ? NE  ? A ARG 22 NE  
4   1 Y 1 A ARG 22 ? CZ  ? A ARG 22 CZ  
5   1 Y 1 A ARG 22 ? NH1 ? A ARG 22 NH1 
6   1 Y 1 A ARG 22 ? NH2 ? A ARG 22 NH2 
7   1 Y 1 A PRO 23 ? CG  ? A PRO 23 CG  
8   1 Y 1 A PRO 23 ? CD  ? A PRO 23 CD  
9   1 Y 1 A LEU 24 ? CG  ? A LEU 24 CG  
10  1 Y 1 A LEU 24 ? CD1 ? A LEU 24 CD1 
11  1 Y 1 A LEU 24 ? CD2 ? A LEU 24 CD2 
12  1 Y 1 A HIS 25 ? CG  ? A HIS 25 CG  
13  1 Y 1 A HIS 25 ? ND1 ? A HIS 25 ND1 
14  1 Y 1 A HIS 25 ? CD2 ? A HIS 25 CD2 
15  1 Y 1 A HIS 25 ? CE1 ? A HIS 25 CE1 
16  1 Y 1 A HIS 25 ? NE2 ? A HIS 25 NE2 
17  1 Y 1 A ASP 26 ? CG  ? A ASP 26 CG  
18  1 Y 1 A ASP 26 ? OD1 ? A ASP 26 OD1 
19  1 Y 1 A ASP 26 ? OD2 ? A ASP 26 OD2 
20  1 Y 1 A LEU 27 ? CG  ? A LEU 27 CG  
21  1 Y 1 A LEU 27 ? CD1 ? A LEU 27 CD1 
22  1 Y 1 A LEU 27 ? CD2 ? A LEU 27 CD2 
23  1 Y 1 A CYS 28 ? SG  ? A CYS 28 SG  
24  1 Y 1 A LYS 29 ? CG  ? A LYS 29 CG  
25  1 Y 1 A LYS 29 ? CD  ? A LYS 29 CD  
26  1 Y 1 A LYS 29 ? CE  ? A LYS 29 CE  
27  1 Y 1 A LYS 29 ? NZ  ? A LYS 29 NZ  
28  1 Y 1 A THR 30 ? OG1 ? A THR 30 OG1 
29  1 Y 1 A THR 30 ? CG2 ? A THR 30 CG2 
30  1 Y 1 A THR 31 ? OG1 ? A THR 31 OG1 
31  1 Y 1 A THR 31 ? CG2 ? A THR 31 CG2 
32  1 Y 1 A ILE 32 ? CG1 ? A ILE 32 CG1 
33  1 Y 1 A ILE 32 ? CG2 ? A ILE 32 CG2 
34  1 Y 1 A ILE 32 ? CD1 ? A ILE 32 CD1 
35  1 Y 1 A THR 33 ? OG1 ? A THR 33 OG1 
36  1 Y 1 A THR 33 ? CG2 ? A THR 33 CG2 
37  1 Y 1 A SER 34 ? OG  ? A SER 34 OG  
38  1 Y 1 A SER 35 ? OG  ? A SER 35 OG  
39  1 Y 1 A HIS 36 ? CG  ? A HIS 36 CG  
40  1 Y 1 A HIS 36 ? ND1 ? A HIS 36 ND1 
41  1 Y 1 A HIS 36 ? CD2 ? A HIS 36 CD2 
42  1 Y 1 A HIS 36 ? CE1 ? A HIS 36 CE1 
43  1 Y 1 A HIS 36 ? NE2 ? A HIS 36 NE2 
44  1 Y 1 A HIS 37 ? CG  ? A HIS 37 CG  
45  1 Y 1 A HIS 37 ? ND1 ? A HIS 37 ND1 
46  1 Y 1 A HIS 37 ? CD2 ? A HIS 37 CD2 
47  1 Y 1 A HIS 37 ? CE1 ? A HIS 37 CE1 
48  1 Y 1 A HIS 37 ? NE2 ? A HIS 37 NE2 
49  1 Y 1 A SER 38 ? OG  ? A SER 38 OG  
50  1 Y 1 A SER 39 ? OG  ? A SER 39 OG  
51  1 Y 1 A LYS 40 ? CG  ? A LYS 40 CG  
52  1 Y 1 A LYS 40 ? CD  ? A LYS 40 CD  
53  1 Y 1 A LYS 40 ? CE  ? A LYS 40 CE  
54  1 Y 1 A LYS 40 ? NZ  ? A LYS 40 NZ  
55  1 Y 1 A THR 41 ? OG1 ? A THR 41 OG1 
56  1 Y 1 A THR 41 ? CG2 ? A THR 41 CG2 
57  1 Y 1 A ILE 42 ? CG1 ? A ILE 42 CG1 
58  1 Y 1 A ILE 42 ? CG2 ? A ILE 42 CG2 
59  1 Y 1 A ILE 42 ? CD1 ? A ILE 42 CD1 
60  1 Y 1 B ARG 22 ? CG  ? B ARG 22 CG  
61  1 Y 1 B ARG 22 ? CD  ? B ARG 22 CD  
62  1 Y 1 B ARG 22 ? NE  ? B ARG 22 NE  
63  1 Y 1 B ARG 22 ? CZ  ? B ARG 22 CZ  
64  1 Y 1 B ARG 22 ? NH1 ? B ARG 22 NH1 
65  1 Y 1 B ARG 22 ? NH2 ? B ARG 22 NH2 
66  1 Y 1 B PRO 23 ? CG  ? B PRO 23 CG  
67  1 Y 1 B PRO 23 ? CD  ? B PRO 23 CD  
68  1 Y 1 B LEU 24 ? CG  ? B LEU 24 CG  
69  1 Y 1 B LEU 24 ? CD1 ? B LEU 24 CD1 
70  1 Y 1 B LEU 24 ? CD2 ? B LEU 24 CD2 
71  1 Y 1 B HIS 25 ? CG  ? B HIS 25 CG  
72  1 Y 1 B HIS 25 ? ND1 ? B HIS 25 ND1 
73  1 Y 1 B HIS 25 ? CD2 ? B HIS 25 CD2 
74  1 Y 1 B HIS 25 ? CE1 ? B HIS 25 CE1 
75  1 Y 1 B HIS 25 ? NE2 ? B HIS 25 NE2 
76  1 Y 1 B ASP 26 ? CG  ? B ASP 26 CG  
77  1 Y 1 B ASP 26 ? OD1 ? B ASP 26 OD1 
78  1 Y 1 B ASP 26 ? OD2 ? B ASP 26 OD2 
79  1 Y 1 B LEU 27 ? CG  ? B LEU 27 CG  
80  1 Y 1 B LEU 27 ? CD1 ? B LEU 27 CD1 
81  1 Y 1 B LEU 27 ? CD2 ? B LEU 27 CD2 
82  1 Y 1 B CYS 28 ? SG  ? B CYS 28 SG  
83  1 Y 1 B LYS 29 ? CG  ? B LYS 29 CG  
84  1 Y 1 B LYS 29 ? CD  ? B LYS 29 CD  
85  1 Y 1 B LYS 29 ? CE  ? B LYS 29 CE  
86  1 Y 1 B LYS 29 ? NZ  ? B LYS 29 NZ  
87  1 Y 1 B THR 30 ? OG1 ? B THR 30 OG1 
88  1 Y 1 B THR 30 ? CG2 ? B THR 30 CG2 
89  1 Y 1 B THR 31 ? OG1 ? B THR 31 OG1 
90  1 Y 1 B THR 31 ? CG2 ? B THR 31 CG2 
91  1 Y 1 B ILE 32 ? CG1 ? B ILE 32 CG1 
92  1 Y 1 B ILE 32 ? CG2 ? B ILE 32 CG2 
93  1 Y 1 B ILE 32 ? CD1 ? B ILE 32 CD1 
94  1 Y 1 B THR 33 ? OG1 ? B THR 33 OG1 
95  1 Y 1 B THR 33 ? CG2 ? B THR 33 CG2 
96  1 Y 1 B SER 34 ? OG  ? B SER 34 OG  
97  1 Y 1 B SER 35 ? OG  ? B SER 35 OG  
98  1 Y 1 B HIS 36 ? CG  ? B HIS 36 CG  
99  1 Y 1 B HIS 36 ? ND1 ? B HIS 36 ND1 
100 1 Y 1 B HIS 36 ? CD2 ? B HIS 36 CD2 
101 1 Y 1 B HIS 36 ? CE1 ? B HIS 36 CE1 
102 1 Y 1 B HIS 36 ? NE2 ? B HIS 36 NE2 
103 1 Y 1 B HIS 37 ? CG  ? B HIS 37 CG  
104 1 Y 1 B HIS 37 ? ND1 ? B HIS 37 ND1 
105 1 Y 1 B HIS 37 ? CD2 ? B HIS 37 CD2 
106 1 Y 1 B HIS 37 ? CE1 ? B HIS 37 CE1 
107 1 Y 1 B HIS 37 ? NE2 ? B HIS 37 NE2 
108 1 Y 1 B SER 38 ? OG  ? B SER 38 OG  
109 1 Y 1 B SER 39 ? OG  ? B SER 39 OG  
110 1 Y 1 B LYS 40 ? CG  ? B LYS 40 CG  
111 1 Y 1 B LYS 40 ? CD  ? B LYS 40 CD  
112 1 Y 1 B LYS 40 ? CE  ? B LYS 40 CE  
113 1 Y 1 B LYS 40 ? NZ  ? B LYS 40 NZ  
114 1 Y 1 B THR 41 ? OG1 ? B THR 41 OG1 
115 1 Y 1 B THR 41 ? CG2 ? B THR 41 CG2 
116 1 Y 1 B ILE 42 ? CG1 ? B ILE 42 CG1 
117 1 Y 1 B ILE 42 ? CG2 ? B ILE 42 CG2 
118 1 Y 1 B ILE 42 ? CD1 ? B ILE 42 CD1 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YJP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YJP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YJP 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8YJP 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004  ? 5066 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.701  ? 6915 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 12.008 ? 824  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.047  ? 872  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.006  ? 768  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8YJP 
_struct.title                        'Cryo-EM structure of human apo GPR156' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YJP 
_struct_keywords.text            'GPCR, class C, GPR156, cryo-EM, homodimer, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 2 ? 
M N N 2 ? 
N N N 3 ? 
O N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    GP156_HUMAN 
_struct_ref.pdbx_db_accession          Q8NFN8 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIV
KMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVII
KDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGA
YLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEE
ENQTIRRMAKYFSTPNKSFHTQYGEE
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YJP A 1 ? 346 ? Q8NFN8 1 ? 346 ? 1 346 
2 1 8YJP B 1 ? 346 ? Q8NFN8 1 ? 346 ? 1 346 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 23  ? SER A 34  ? PRO A 23  SER A 34  1 ? 12 
HELX_P HELX_P2  AA2 SER A 46  ? CYS A 74  ? SER A 46  CYS A 74  1 ? 29 
HELX_P HELX_P3  AA3 ASN A 77  ? SER A 83  ? ASN A 77  SER A 83  1 ? 7  
HELX_P HELX_P4  AA4 SER A 84  ? GLY A 106 ? SER A 84  GLY A 106 1 ? 23 
HELX_P HELX_P5  AA5 SER A 114 ? THR A 150 ? SER A 114 THR A 150 1 ? 37 
HELX_P HELX_P6  AA6 LYS A 161 ? ASP A 187 ? LYS A 161 ASP A 187 1 ? 27 
HELX_P HELX_P7  AA7 TYR A 220 ? THR A 246 ? TYR A 220 THR A 246 1 ? 27 
HELX_P HELX_P8  AA8 SER A 251 ? GLN A 256 ? SER A 251 GLN A 256 1 ? 6  
HELX_P HELX_P9  AA9 GLN A 256 ? LEU A 281 ? GLN A 256 LEU A 281 1 ? 26 
HELX_P HELX_P10 AB1 TRP A 284 ? GLU A 319 ? TRP A 284 GLU A 319 1 ? 36 
HELX_P HELX_P11 AB2 PRO B 23  ? SER B 34  ? PRO B 23  SER B 34  1 ? 12 
HELX_P HELX_P12 AB3 VAL B 48  ? CYS B 74  ? VAL B 48  CYS B 74  1 ? 27 
HELX_P HELX_P13 AB4 ASN B 77  ? SER B 83  ? ASN B 77  SER B 83  1 ? 7  
HELX_P HELX_P14 AB5 SER B 84  ? GLY B 106 ? SER B 84  GLY B 106 1 ? 23 
HELX_P HELX_P15 AB6 SER B 114 ? GLN B 151 ? SER B 114 GLN B 151 1 ? 38 
HELX_P HELX_P16 AB7 LYS B 161 ? ASP B 187 ? LYS B 161 ASP B 187 1 ? 27 
HELX_P HELX_P17 AB8 TYR B 220 ? THR B 246 ? TYR B 220 THR B 246 1 ? 27 
HELX_P HELX_P18 AB9 SER B 251 ? GLN B 256 ? SER B 251 GLN B 256 1 ? 6  
HELX_P HELX_P19 AC1 GLN B 256 ? LEU B 281 ? GLN B 256 LEU B 281 1 ? 26 
HELX_P HELX_P20 AC2 TRP B 284 ? GLU B 319 ? TRP B 284 GLU B 319 1 ? 36 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            191 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            216 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             191 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             216 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.438 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       191 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      216 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        191 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       216 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 209 ? CYS A 216 ? THR A 209 CYS A 216 
AA1 2 CYS A 191 ? VAL A 201 ? CYS A 191 VAL A 201 
AA1 3 GLN B 190 ? VAL B 201 ? GLN B 190 VAL B 201 
AA1 4 VAL B 206 ? ALA B 217 ? VAL B 206 ALA B 217 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O THR A 211 ? O THR A 211 N SER A 196 ? N SER A 196 
AA1 2 3 N GLN A 193 ? N GLN A 193 O VAL B 201 ? O VAL B 201 
AA1 3 4 N SER B 198 ? N SER B 198 O THR B 209 ? O THR B 209 
# 
_pdbx_entry_details.entry_id                   8YJP 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PRO A 23  ? ? -67.24  1.20    
2  1 THR A 41  ? ? 70.22   150.62  
3  1 SER A 44  ? ? -141.08 32.99   
4  1 SER A 84  ? ? 57.88   73.98   
5  1 SER A 115 ? ? -39.95  -37.29  
6  1 ASP A 187 ? ? -160.15 88.50   
7  1 HIS A 282 ? ? -83.58  46.90   
8  1 SER B 34  ? ? -74.30  21.71   
9  1 HIS B 37  ? ? 73.11   -25.51  
10 1 SER B 38  ? ? 62.63   -140.82 
11 1 PRO B 47  ? ? -79.67  43.26   
12 1 ARG B 75  ? ? -89.09  46.61   
13 1 SER B 84  ? ? 54.38   75.48   
14 1 PRO B 253 ? ? -55.73  -3.26   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8YJP 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8YJP 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.09 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               164823 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.name                 GPR156 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8YJP 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             700 
_em_imaging.nominal_defocus_max             1500 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_vitrification.entry_id              8YJP 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8YJP 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A GLU 2   ? A GLU 2   
3  1 Y 1 A PRO 3   ? A PRO 3   
4  1 Y 1 A GLU 4   ? A GLU 4   
5  1 Y 1 A ILE 5   ? A ILE 5   
6  1 Y 1 A ASN 6   ? A ASN 6   
7  1 Y 1 A CYS 7   ? A CYS 7   
8  1 Y 1 A SER 8   ? A SER 8   
9  1 Y 1 A GLU 9   ? A GLU 9   
10 1 Y 1 A LEU 10  ? A LEU 10  
11 1 Y 1 A CYS 11  ? A CYS 11  
12 1 Y 1 A ASP 12  ? A ASP 12  
13 1 Y 1 A SER 13  ? A SER 13  
14 1 Y 1 A PHE 14  ? A PHE 14  
15 1 Y 1 A PRO 15  ? A PRO 15  
16 1 Y 1 A GLY 16  ? A GLY 16  
17 1 Y 1 A GLN 17  ? A GLN 17  
18 1 Y 1 A GLU 18  ? A GLU 18  
19 1 Y 1 A LEU 19  ? A LEU 19  
20 1 Y 1 A ASP 20  ? A ASP 20  
21 1 Y 1 A ARG 21  ? A ARG 21  
22 1 Y 1 A GLU 320 ? A GLU 320 
23 1 Y 1 A GLU 321 ? A GLU 321 
24 1 Y 1 A ASN 322 ? A ASN 322 
25 1 Y 1 A GLN 323 ? A GLN 323 
26 1 Y 1 A THR 324 ? A THR 324 
27 1 Y 1 A ILE 325 ? A ILE 325 
28 1 Y 1 A ARG 326 ? A ARG 326 
29 1 Y 1 A ARG 327 ? A ARG 327 
30 1 Y 1 A MET 328 ? A MET 328 
31 1 Y 1 A ALA 329 ? A ALA 329 
32 1 Y 1 A LYS 330 ? A LYS 330 
33 1 Y 1 A TYR 331 ? A TYR 331 
34 1 Y 1 A PHE 332 ? A PHE 332 
35 1 Y 1 A SER 333 ? A SER 333 
36 1 Y 1 A THR 334 ? A THR 334 
37 1 Y 1 A PRO 335 ? A PRO 335 
38 1 Y 1 A ASN 336 ? A ASN 336 
39 1 Y 1 A LYS 337 ? A LYS 337 
40 1 Y 1 A SER 338 ? A SER 338 
41 1 Y 1 A PHE 339 ? A PHE 339 
42 1 Y 1 A HIS 340 ? A HIS 340 
43 1 Y 1 A THR 341 ? A THR 341 
44 1 Y 1 A GLN 342 ? A GLN 342 
45 1 Y 1 A TYR 343 ? A TYR 343 
46 1 Y 1 A GLY 344 ? A GLY 344 
47 1 Y 1 A GLU 345 ? A GLU 345 
48 1 Y 1 A GLU 346 ? A GLU 346 
49 1 Y 1 B MET 1   ? B MET 1   
50 1 Y 1 B GLU 2   ? B GLU 2   
51 1 Y 1 B PRO 3   ? B PRO 3   
52 1 Y 1 B GLU 4   ? B GLU 4   
53 1 Y 1 B ILE 5   ? B ILE 5   
54 1 Y 1 B ASN 6   ? B ASN 6   
55 1 Y 1 B CYS 7   ? B CYS 7   
56 1 Y 1 B SER 8   ? B SER 8   
57 1 Y 1 B GLU 9   ? B GLU 9   
58 1 Y 1 B LEU 10  ? B LEU 10  
59 1 Y 1 B CYS 11  ? B CYS 11  
60 1 Y 1 B ASP 12  ? B ASP 12  
61 1 Y 1 B SER 13  ? B SER 13  
62 1 Y 1 B PHE 14  ? B PHE 14  
63 1 Y 1 B PRO 15  ? B PRO 15  
64 1 Y 1 B GLY 16  ? B GLY 16  
65 1 Y 1 B GLN 17  ? B GLN 17  
66 1 Y 1 B GLU 18  ? B GLU 18  
67 1 Y 1 B LEU 19  ? B LEU 19  
68 1 Y 1 B ASP 20  ? B ASP 20  
69 1 Y 1 B ARG 21  ? B ARG 21  
70 1 Y 1 B GLU 320 ? B GLU 320 
71 1 Y 1 B GLU 321 ? B GLU 321 
72 1 Y 1 B ASN 322 ? B ASN 322 
73 1 Y 1 B GLN 323 ? B GLN 323 
74 1 Y 1 B THR 324 ? B THR 324 
75 1 Y 1 B ILE 325 ? B ILE 325 
76 1 Y 1 B ARG 326 ? B ARG 326 
77 1 Y 1 B ARG 327 ? B ARG 327 
78 1 Y 1 B MET 328 ? B MET 328 
79 1 Y 1 B ALA 329 ? B ALA 329 
80 1 Y 1 B LYS 330 ? B LYS 330 
81 1 Y 1 B TYR 331 ? B TYR 331 
82 1 Y 1 B PHE 332 ? B PHE 332 
83 1 Y 1 B SER 333 ? B SER 333 
84 1 Y 1 B THR 334 ? B THR 334 
85 1 Y 1 B PRO 335 ? B PRO 335 
86 1 Y 1 B ASN 336 ? B ASN 336 
87 1 Y 1 B LYS 337 ? B LYS 337 
88 1 Y 1 B SER 338 ? B SER 338 
89 1 Y 1 B PHE 339 ? B PHE 339 
90 1 Y 1 B HIS 340 ? B HIS 340 
91 1 Y 1 B THR 341 ? B THR 341 
92 1 Y 1 B GLN 342 ? B GLN 342 
93 1 Y 1 B TYR 343 ? B TYR 343 
94 1 Y 1 B GLY 344 ? B GLY 344 
95 1 Y 1 B GLU 345 ? B GLU 345 
96 1 Y 1 B GLU 346 ? B GLU 346 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CLR C1   C N N 74  
CLR C2   C N N 75  
CLR C3   C N S 76  
CLR C4   C N N 77  
CLR C5   C N N 78  
CLR C6   C N N 79  
CLR C7   C N N 80  
CLR C8   C N S 81  
CLR C9   C N S 82  
CLR C10  C N R 83  
CLR C11  C N N 84  
CLR C12  C N N 85  
CLR C13  C N R 86  
CLR C14  C N S 87  
CLR C15  C N N 88  
CLR C16  C N N 89  
CLR C17  C N R 90  
CLR C18  C N N 91  
CLR C19  C N N 92  
CLR C20  C N R 93  
CLR C21  C N N 94  
CLR C22  C N N 95  
CLR C23  C N N 96  
CLR C24  C N N 97  
CLR C25  C N N 98  
CLR C26  C N N 99  
CLR C27  C N N 100 
CLR O1   O N N 101 
CLR H11  H N N 102 
CLR H12  H N N 103 
CLR H21  H N N 104 
CLR H22  H N N 105 
CLR H3   H N N 106 
CLR H41  H N N 107 
CLR H42  H N N 108 
CLR H6   H N N 109 
CLR H71  H N N 110 
CLR H72  H N N 111 
CLR H8   H N N 112 
CLR H9   H N N 113 
CLR H111 H N N 114 
CLR H112 H N N 115 
CLR H121 H N N 116 
CLR H122 H N N 117 
CLR H14  H N N 118 
CLR H151 H N N 119 
CLR H152 H N N 120 
CLR H161 H N N 121 
CLR H162 H N N 122 
CLR H17  H N N 123 
CLR H181 H N N 124 
CLR H182 H N N 125 
CLR H183 H N N 126 
CLR H191 H N N 127 
CLR H192 H N N 128 
CLR H193 H N N 129 
CLR H20  H N N 130 
CLR H211 H N N 131 
CLR H212 H N N 132 
CLR H213 H N N 133 
CLR H221 H N N 134 
CLR H222 H N N 135 
CLR H231 H N N 136 
CLR H232 H N N 137 
CLR H241 H N N 138 
CLR H242 H N N 139 
CLR H25  H N N 140 
CLR H261 H N N 141 
CLR H262 H N N 142 
CLR H263 H N N 143 
CLR H271 H N N 144 
CLR H272 H N N 145 
CLR H273 H N N 146 
CLR H1   H N N 147 
CYS N    N N N 148 
CYS CA   C N R 149 
CYS C    C N N 150 
CYS O    O N N 151 
CYS CB   C N N 152 
CYS SG   S N N 153 
CYS OXT  O N N 154 
CYS H    H N N 155 
CYS H2   H N N 156 
CYS HA   H N N 157 
CYS HB2  H N N 158 
CYS HB3  H N N 159 
CYS HG   H N N 160 
CYS HXT  H N N 161 
GLN N    N N N 162 
GLN CA   C N S 163 
GLN C    C N N 164 
GLN O    O N N 165 
GLN CB   C N N 166 
GLN CG   C N N 167 
GLN CD   C N N 168 
GLN OE1  O N N 169 
GLN NE2  N N N 170 
GLN OXT  O N N 171 
GLN H    H N N 172 
GLN H2   H N N 173 
GLN HA   H N N 174 
GLN HB2  H N N 175 
GLN HB3  H N N 176 
GLN HG2  H N N 177 
GLN HG3  H N N 178 
GLN HE21 H N N 179 
GLN HE22 H N N 180 
GLN HXT  H N N 181 
GLU N    N N N 182 
GLU CA   C N S 183 
GLU C    C N N 184 
GLU O    O N N 185 
GLU CB   C N N 186 
GLU CG   C N N 187 
GLU CD   C N N 188 
GLU OE1  O N N 189 
GLU OE2  O N N 190 
GLU OXT  O N N 191 
GLU H    H N N 192 
GLU H2   H N N 193 
GLU HA   H N N 194 
GLU HB2  H N N 195 
GLU HB3  H N N 196 
GLU HG2  H N N 197 
GLU HG3  H N N 198 
GLU HE2  H N N 199 
GLU HXT  H N N 200 
GLY N    N N N 201 
GLY CA   C N N 202 
GLY C    C N N 203 
GLY O    O N N 204 
GLY OXT  O N N 205 
GLY H    H N N 206 
GLY H2   H N N 207 
GLY HA2  H N N 208 
GLY HA3  H N N 209 
GLY HXT  H N N 210 
HIS N    N N N 211 
HIS CA   C N S 212 
HIS C    C N N 213 
HIS O    O N N 214 
HIS CB   C N N 215 
HIS CG   C Y N 216 
HIS ND1  N Y N 217 
HIS CD2  C Y N 218 
HIS CE1  C Y N 219 
HIS NE2  N Y N 220 
HIS OXT  O N N 221 
HIS H    H N N 222 
HIS H2   H N N 223 
HIS HA   H N N 224 
HIS HB2  H N N 225 
HIS HB3  H N N 226 
HIS HD1  H N N 227 
HIS HD2  H N N 228 
HIS HE1  H N N 229 
HIS HE2  H N N 230 
HIS HXT  H N N 231 
ILE N    N N N 232 
ILE CA   C N S 233 
ILE C    C N N 234 
ILE O    O N N 235 
ILE CB   C N S 236 
ILE CG1  C N N 237 
ILE CG2  C N N 238 
ILE CD1  C N N 239 
ILE OXT  O N N 240 
ILE H    H N N 241 
ILE H2   H N N 242 
ILE HA   H N N 243 
ILE HB   H N N 244 
ILE HG12 H N N 245 
ILE HG13 H N N 246 
ILE HG21 H N N 247 
ILE HG22 H N N 248 
ILE HG23 H N N 249 
ILE HD11 H N N 250 
ILE HD12 H N N 251 
ILE HD13 H N N 252 
ILE HXT  H N N 253 
LEU N    N N N 254 
LEU CA   C N S 255 
LEU C    C N N 256 
LEU O    O N N 257 
LEU CB   C N N 258 
LEU CG   C N N 259 
LEU CD1  C N N 260 
LEU CD2  C N N 261 
LEU OXT  O N N 262 
LEU H    H N N 263 
LEU H2   H N N 264 
LEU HA   H N N 265 
LEU HB2  H N N 266 
LEU HB3  H N N 267 
LEU HG   H N N 268 
LEU HD11 H N N 269 
LEU HD12 H N N 270 
LEU HD13 H N N 271 
LEU HD21 H N N 272 
LEU HD22 H N N 273 
LEU HD23 H N N 274 
LEU HXT  H N N 275 
LYS N    N N N 276 
LYS CA   C N S 277 
LYS C    C N N 278 
LYS O    O N N 279 
LYS CB   C N N 280 
LYS CG   C N N 281 
LYS CD   C N N 282 
LYS CE   C N N 283 
LYS NZ   N N N 284 
LYS OXT  O N N 285 
LYS H    H N N 286 
LYS H2   H N N 287 
LYS HA   H N N 288 
LYS HB2  H N N 289 
LYS HB3  H N N 290 
LYS HG2  H N N 291 
LYS HG3  H N N 292 
LYS HD2  H N N 293 
LYS HD3  H N N 294 
LYS HE2  H N N 295 
LYS HE3  H N N 296 
LYS HZ1  H N N 297 
LYS HZ2  H N N 298 
LYS HZ3  H N N 299 
LYS HXT  H N N 300 
MET N    N N N 301 
MET CA   C N S 302 
MET C    C N N 303 
MET O    O N N 304 
MET CB   C N N 305 
MET CG   C N N 306 
MET SD   S N N 307 
MET CE   C N N 308 
MET OXT  O N N 309 
MET H    H N N 310 
MET H2   H N N 311 
MET HA   H N N 312 
MET HB2  H N N 313 
MET HB3  H N N 314 
MET HG2  H N N 315 
MET HG3  H N N 316 
MET HE1  H N N 317 
MET HE2  H N N 318 
MET HE3  H N N 319 
MET HXT  H N N 320 
MW9 C    C N N 321 
MW9 O    O N N 322 
MW9 C1   C N N 323 
MW9 C10  C N N 324 
MW9 C11  C N N 325 
MW9 C12  C N N 326 
MW9 C13  C N N 327 
MW9 C14  C N N 328 
MW9 C15  C N N 329 
MW9 C16  C N N 330 
MW9 C17  C N N 331 
MW9 C18  C N N 332 
MW9 C19  C N R 333 
MW9 C2   C N N 334 
MW9 C20  C N N 335 
MW9 C21  C N N 336 
MW9 C22  C N S 337 
MW9 C23  C N N 338 
MW9 C24  C N N 339 
MW9 C25  C N N 340 
MW9 C26  C N N 341 
MW9 C27  C N N 342 
MW9 C28  C N N 343 
MW9 C29  C N N 344 
MW9 C3   C N N 345 
MW9 C30  C N N 346 
MW9 C31  C N N 347 
MW9 C32  C N N 348 
MW9 C33  C N N 349 
MW9 C34  C N N 350 
MW9 C35  C N N 351 
MW9 C36  C N N 352 
MW9 C37  C N N 353 
MW9 C38  C N N 354 
MW9 C39  C N N 355 
MW9 C4   C N N 356 
MW9 C40  C N N 357 
MW9 C41  C N N 358 
MW9 C5   C N N 359 
MW9 C6   C N N 360 
MW9 C7   C N N 361 
MW9 C8   C N N 362 
MW9 C9   C N N 363 
MW9 O1   O N N 364 
MW9 O2   O N N 365 
MW9 O3   O N N 366 
MW9 O4   O N N 367 
MW9 O5   O N N 368 
MW9 O6   O N N 369 
MW9 O7   O N N 370 
MW9 O8   O N N 371 
MW9 O9   O N N 372 
MW9 P    P N N 373 
MW9 H1   H N N 374 
MW9 H2   H N N 375 
MW9 H3   H N N 376 
MW9 H4   H N N 377 
MW9 H5   H N N 378 
MW9 H6   H N N 379 
MW9 H7   H N N 380 
MW9 H8   H N N 381 
MW9 H9   H N N 382 
MW9 H10  H N N 383 
MW9 H11  H N N 384 
MW9 H12  H N N 385 
MW9 H13  H N N 386 
MW9 H14  H N N 387 
MW9 H15  H N N 388 
MW9 H16  H N N 389 
MW9 H17  H N N 390 
MW9 H18  H N N 391 
MW9 H19  H N N 392 
MW9 H20  H N N 393 
MW9 H21  H N N 394 
MW9 H22  H N N 395 
MW9 H23  H N N 396 
MW9 H24  H N N 397 
MW9 H25  H N N 398 
MW9 H26  H N N 399 
MW9 H27  H N N 400 
MW9 H28  H N N 401 
MW9 H29  H N N 402 
MW9 H30  H N N 403 
MW9 H31  H N N 404 
MW9 H32  H N N 405 
MW9 H33  H N N 406 
MW9 H34  H N N 407 
MW9 H35  H N N 408 
MW9 H36  H N N 409 
MW9 H37  H N N 410 
MW9 H38  H N N 411 
MW9 H39  H N N 412 
MW9 H40  H N N 413 
MW9 H41  H N N 414 
MW9 H42  H N N 415 
MW9 H43  H N N 416 
MW9 H44  H N N 417 
MW9 H45  H N N 418 
MW9 H46  H N N 419 
MW9 H47  H N N 420 
MW9 H48  H N N 421 
MW9 H49  H N N 422 
MW9 H50  H N N 423 
MW9 H51  H N N 424 
MW9 H52  H N N 425 
MW9 H53  H N N 426 
MW9 H54  H N N 427 
MW9 H55  H N N 428 
MW9 H56  H N N 429 
MW9 H57  H N N 430 
MW9 H58  H N N 431 
MW9 H59  H N N 432 
MW9 H60  H N N 433 
MW9 H61  H N N 434 
MW9 H62  H N N 435 
MW9 H63  H N N 436 
MW9 H64  H N N 437 
MW9 H65  H N N 438 
MW9 H66  H N N 439 
MW9 H67  H N N 440 
MW9 H68  H N N 441 
MW9 H69  H N N 442 
MW9 H70  H N N 443 
MW9 H71  H N N 444 
MW9 H72  H N N 445 
MW9 H73  H N N 446 
MW9 H74  H N N 447 
MW9 H75  H N N 448 
MW9 H76  H N N 449 
MW9 H77  H N N 450 
MW9 H78  H N N 451 
MW9 H79  H N N 452 
MW9 H80  H N N 453 
MW9 H81  H N N 454 
PHE N    N N N 455 
PHE CA   C N S 456 
PHE C    C N N 457 
PHE O    O N N 458 
PHE CB   C N N 459 
PHE CG   C Y N 460 
PHE CD1  C Y N 461 
PHE CD2  C Y N 462 
PHE CE1  C Y N 463 
PHE CE2  C Y N 464 
PHE CZ   C Y N 465 
PHE OXT  O N N 466 
PHE H    H N N 467 
PHE H2   H N N 468 
PHE HA   H N N 469 
PHE HB2  H N N 470 
PHE HB3  H N N 471 
PHE HD1  H N N 472 
PHE HD2  H N N 473 
PHE HE1  H N N 474 
PHE HE2  H N N 475 
PHE HZ   H N N 476 
PHE HXT  H N N 477 
PRO N    N N N 478 
PRO CA   C N S 479 
PRO C    C N N 480 
PRO O    O N N 481 
PRO CB   C N N 482 
PRO CG   C N N 483 
PRO CD   C N N 484 
PRO OXT  O N N 485 
PRO H    H N N 486 
PRO HA   H N N 487 
PRO HB2  H N N 488 
PRO HB3  H N N 489 
PRO HG2  H N N 490 
PRO HG3  H N N 491 
PRO HD2  H N N 492 
PRO HD3  H N N 493 
PRO HXT  H N N 494 
SER N    N N N 495 
SER CA   C N S 496 
SER C    C N N 497 
SER O    O N N 498 
SER CB   C N N 499 
SER OG   O N N 500 
SER OXT  O N N 501 
SER H    H N N 502 
SER H2   H N N 503 
SER HA   H N N 504 
SER HB2  H N N 505 
SER HB3  H N N 506 
SER HG   H N N 507 
SER HXT  H N N 508 
THR N    N N N 509 
THR CA   C N S 510 
THR C    C N N 511 
THR O    O N N 512 
THR CB   C N R 513 
THR OG1  O N N 514 
THR CG2  C N N 515 
THR OXT  O N N 516 
THR H    H N N 517 
THR H2   H N N 518 
THR HA   H N N 519 
THR HB   H N N 520 
THR HG1  H N N 521 
THR HG21 H N N 522 
THR HG22 H N N 523 
THR HG23 H N N 524 
THR HXT  H N N 525 
TRP N    N N N 526 
TRP CA   C N S 527 
TRP C    C N N 528 
TRP O    O N N 529 
TRP CB   C N N 530 
TRP CG   C Y N 531 
TRP CD1  C Y N 532 
TRP CD2  C Y N 533 
TRP NE1  N Y N 534 
TRP CE2  C Y N 535 
TRP CE3  C Y N 536 
TRP CZ2  C Y N 537 
TRP CZ3  C Y N 538 
TRP CH2  C Y N 539 
TRP OXT  O N N 540 
TRP H    H N N 541 
TRP H2   H N N 542 
TRP HA   H N N 543 
TRP HB2  H N N 544 
TRP HB3  H N N 545 
TRP HD1  H N N 546 
TRP HE1  H N N 547 
TRP HE3  H N N 548 
TRP HZ2  H N N 549 
TRP HZ3  H N N 550 
TRP HH2  H N N 551 
TRP HXT  H N N 552 
TYR N    N N N 553 
TYR CA   C N S 554 
TYR C    C N N 555 
TYR O    O N N 556 
TYR CB   C N N 557 
TYR CG   C Y N 558 
TYR CD1  C Y N 559 
TYR CD2  C Y N 560 
TYR CE1  C Y N 561 
TYR CE2  C Y N 562 
TYR CZ   C Y N 563 
TYR OH   O N N 564 
TYR OXT  O N N 565 
TYR H    H N N 566 
TYR H2   H N N 567 
TYR HA   H N N 568 
TYR HB2  H N N 569 
TYR HB3  H N N 570 
TYR HD1  H N N 571 
TYR HD2  H N N 572 
TYR HE1  H N N 573 
TYR HE2  H N N 574 
TYR HH   H N N 575 
TYR HXT  H N N 576 
VAL N    N N N 577 
VAL CA   C N S 578 
VAL C    C N N 579 
VAL O    O N N 580 
VAL CB   C N N 581 
VAL CG1  C N N 582 
VAL CG2  C N N 583 
VAL OXT  O N N 584 
VAL H    H N N 585 
VAL H2   H N N 586 
VAL HA   H N N 587 
VAL HB   H N N 588 
VAL HG11 H N N 589 
VAL HG12 H N N 590 
VAL HG13 H N N 591 
VAL HG21 H N N 592 
VAL HG22 H N N 593 
VAL HG23 H N N 594 
VAL HXT  H N N 595 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CLR C1  C2   sing N N 70  
CLR C1  C10  sing N N 71  
CLR C1  H11  sing N N 72  
CLR C1  H12  sing N N 73  
CLR C2  C3   sing N N 74  
CLR C2  H21  sing N N 75  
CLR C2  H22  sing N N 76  
CLR C3  C4   sing N N 77  
CLR C3  O1   sing N N 78  
CLR C3  H3   sing N N 79  
CLR C4  C5   sing N N 80  
CLR C4  H41  sing N N 81  
CLR C4  H42  sing N N 82  
CLR C5  C6   doub N N 83  
CLR C5  C10  sing N N 84  
CLR C6  C7   sing N N 85  
CLR C6  H6   sing N N 86  
CLR C7  C8   sing N N 87  
CLR C7  H71  sing N N 88  
CLR C7  H72  sing N N 89  
CLR C8  C9   sing N N 90  
CLR C8  C14  sing N N 91  
CLR C8  H8   sing N N 92  
CLR C9  C10  sing N N 93  
CLR C9  C11  sing N N 94  
CLR C9  H9   sing N N 95  
CLR C10 C19  sing N N 96  
CLR C11 C12  sing N N 97  
CLR C11 H111 sing N N 98  
CLR C11 H112 sing N N 99  
CLR C12 C13  sing N N 100 
CLR C12 H121 sing N N 101 
CLR C12 H122 sing N N 102 
CLR C13 C14  sing N N 103 
CLR C13 C17  sing N N 104 
CLR C13 C18  sing N N 105 
CLR C14 C15  sing N N 106 
CLR C14 H14  sing N N 107 
CLR C15 C16  sing N N 108 
CLR C15 H151 sing N N 109 
CLR C15 H152 sing N N 110 
CLR C16 C17  sing N N 111 
CLR C16 H161 sing N N 112 
CLR C16 H162 sing N N 113 
CLR C17 C20  sing N N 114 
CLR C17 H17  sing N N 115 
CLR C18 H181 sing N N 116 
CLR C18 H182 sing N N 117 
CLR C18 H183 sing N N 118 
CLR C19 H191 sing N N 119 
CLR C19 H192 sing N N 120 
CLR C19 H193 sing N N 121 
CLR C20 C21  sing N N 122 
CLR C20 C22  sing N N 123 
CLR C20 H20  sing N N 124 
CLR C21 H211 sing N N 125 
CLR C21 H212 sing N N 126 
CLR C21 H213 sing N N 127 
CLR C22 C23  sing N N 128 
CLR C22 H221 sing N N 129 
CLR C22 H222 sing N N 130 
CLR C23 C24  sing N N 131 
CLR C23 H231 sing N N 132 
CLR C23 H232 sing N N 133 
CLR C24 C25  sing N N 134 
CLR C24 H241 sing N N 135 
CLR C24 H242 sing N N 136 
CLR C25 C26  sing N N 137 
CLR C25 C27  sing N N 138 
CLR C25 H25  sing N N 139 
CLR C26 H261 sing N N 140 
CLR C26 H262 sing N N 141 
CLR C26 H263 sing N N 142 
CLR C27 H271 sing N N 143 
CLR C27 H272 sing N N 144 
CLR C27 H273 sing N N 145 
CLR O1  H1   sing N N 146 
CYS N   CA   sing N N 147 
CYS N   H    sing N N 148 
CYS N   H2   sing N N 149 
CYS CA  C    sing N N 150 
CYS CA  CB   sing N N 151 
CYS CA  HA   sing N N 152 
CYS C   O    doub N N 153 
CYS C   OXT  sing N N 154 
CYS CB  SG   sing N N 155 
CYS CB  HB2  sing N N 156 
CYS CB  HB3  sing N N 157 
CYS SG  HG   sing N N 158 
CYS OXT HXT  sing N N 159 
GLN N   CA   sing N N 160 
GLN N   H    sing N N 161 
GLN N   H2   sing N N 162 
GLN CA  C    sing N N 163 
GLN CA  CB   sing N N 164 
GLN CA  HA   sing N N 165 
GLN C   O    doub N N 166 
GLN C   OXT  sing N N 167 
GLN CB  CG   sing N N 168 
GLN CB  HB2  sing N N 169 
GLN CB  HB3  sing N N 170 
GLN CG  CD   sing N N 171 
GLN CG  HG2  sing N N 172 
GLN CG  HG3  sing N N 173 
GLN CD  OE1  doub N N 174 
GLN CD  NE2  sing N N 175 
GLN NE2 HE21 sing N N 176 
GLN NE2 HE22 sing N N 177 
GLN OXT HXT  sing N N 178 
GLU N   CA   sing N N 179 
GLU N   H    sing N N 180 
GLU N   H2   sing N N 181 
GLU CA  C    sing N N 182 
GLU CA  CB   sing N N 183 
GLU CA  HA   sing N N 184 
GLU C   O    doub N N 185 
GLU C   OXT  sing N N 186 
GLU CB  CG   sing N N 187 
GLU CB  HB2  sing N N 188 
GLU CB  HB3  sing N N 189 
GLU CG  CD   sing N N 190 
GLU CG  HG2  sing N N 191 
GLU CG  HG3  sing N N 192 
GLU CD  OE1  doub N N 193 
GLU CD  OE2  sing N N 194 
GLU OE2 HE2  sing N N 195 
GLU OXT HXT  sing N N 196 
GLY N   CA   sing N N 197 
GLY N   H    sing N N 198 
GLY N   H2   sing N N 199 
GLY CA  C    sing N N 200 
GLY CA  HA2  sing N N 201 
GLY CA  HA3  sing N N 202 
GLY C   O    doub N N 203 
GLY C   OXT  sing N N 204 
GLY OXT HXT  sing N N 205 
HIS N   CA   sing N N 206 
HIS N   H    sing N N 207 
HIS N   H2   sing N N 208 
HIS CA  C    sing N N 209 
HIS CA  CB   sing N N 210 
HIS CA  HA   sing N N 211 
HIS C   O    doub N N 212 
HIS C   OXT  sing N N 213 
HIS CB  CG   sing N N 214 
HIS CB  HB2  sing N N 215 
HIS CB  HB3  sing N N 216 
HIS CG  ND1  sing Y N 217 
HIS CG  CD2  doub Y N 218 
HIS ND1 CE1  doub Y N 219 
HIS ND1 HD1  sing N N 220 
HIS CD2 NE2  sing Y N 221 
HIS CD2 HD2  sing N N 222 
HIS CE1 NE2  sing Y N 223 
HIS CE1 HE1  sing N N 224 
HIS NE2 HE2  sing N N 225 
HIS OXT HXT  sing N N 226 
ILE N   CA   sing N N 227 
ILE N   H    sing N N 228 
ILE N   H2   sing N N 229 
ILE CA  C    sing N N 230 
ILE CA  CB   sing N N 231 
ILE CA  HA   sing N N 232 
ILE C   O    doub N N 233 
ILE C   OXT  sing N N 234 
ILE CB  CG1  sing N N 235 
ILE CB  CG2  sing N N 236 
ILE CB  HB   sing N N 237 
ILE CG1 CD1  sing N N 238 
ILE CG1 HG12 sing N N 239 
ILE CG1 HG13 sing N N 240 
ILE CG2 HG21 sing N N 241 
ILE CG2 HG22 sing N N 242 
ILE CG2 HG23 sing N N 243 
ILE CD1 HD11 sing N N 244 
ILE CD1 HD12 sing N N 245 
ILE CD1 HD13 sing N N 246 
ILE OXT HXT  sing N N 247 
LEU N   CA   sing N N 248 
LEU N   H    sing N N 249 
LEU N   H2   sing N N 250 
LEU CA  C    sing N N 251 
LEU CA  CB   sing N N 252 
LEU CA  HA   sing N N 253 
LEU C   O    doub N N 254 
LEU C   OXT  sing N N 255 
LEU CB  CG   sing N N 256 
LEU CB  HB2  sing N N 257 
LEU CB  HB3  sing N N 258 
LEU CG  CD1  sing N N 259 
LEU CG  CD2  sing N N 260 
LEU CG  HG   sing N N 261 
LEU CD1 HD11 sing N N 262 
LEU CD1 HD12 sing N N 263 
LEU CD1 HD13 sing N N 264 
LEU CD2 HD21 sing N N 265 
LEU CD2 HD22 sing N N 266 
LEU CD2 HD23 sing N N 267 
LEU OXT HXT  sing N N 268 
LYS N   CA   sing N N 269 
LYS N   H    sing N N 270 
LYS N   H2   sing N N 271 
LYS CA  C    sing N N 272 
LYS CA  CB   sing N N 273 
LYS CA  HA   sing N N 274 
LYS C   O    doub N N 275 
LYS C   OXT  sing N N 276 
LYS CB  CG   sing N N 277 
LYS CB  HB2  sing N N 278 
LYS CB  HB3  sing N N 279 
LYS CG  CD   sing N N 280 
LYS CG  HG2  sing N N 281 
LYS CG  HG3  sing N N 282 
LYS CD  CE   sing N N 283 
LYS CD  HD2  sing N N 284 
LYS CD  HD3  sing N N 285 
LYS CE  NZ   sing N N 286 
LYS CE  HE2  sing N N 287 
LYS CE  HE3  sing N N 288 
LYS NZ  HZ1  sing N N 289 
LYS NZ  HZ2  sing N N 290 
LYS NZ  HZ3  sing N N 291 
LYS OXT HXT  sing N N 292 
MET N   CA   sing N N 293 
MET N   H    sing N N 294 
MET N   H2   sing N N 295 
MET CA  C    sing N N 296 
MET CA  CB   sing N N 297 
MET CA  HA   sing N N 298 
MET C   O    doub N N 299 
MET C   OXT  sing N N 300 
MET CB  CG   sing N N 301 
MET CB  HB2  sing N N 302 
MET CB  HB3  sing N N 303 
MET CG  SD   sing N N 304 
MET CG  HG2  sing N N 305 
MET CG  HG3  sing N N 306 
MET SD  CE   sing N N 307 
MET CE  HE1  sing N N 308 
MET CE  HE2  sing N N 309 
MET CE  HE3  sing N N 310 
MET OXT HXT  sing N N 311 
MW9 C33 C32  doub N Z 312 
MW9 C33 C34  sing N N 313 
MW9 C32 C31  sing N N 314 
MW9 C34 C35  sing N N 315 
MW9 C35 C36  sing N N 316 
MW9 C31 C30  sing N N 317 
MW9 C30 C29  sing N N 318 
MW9 C36 C37  sing N N 319 
MW9 C28 C29  sing N N 320 
MW9 C28 C27  sing N N 321 
MW9 O4  P    doub N N 322 
MW9 C37 C38  sing N N 323 
MW9 C27 C26  sing N N 324 
MW9 C26 C25  sing N N 325 
MW9 O9  C24  doub N N 326 
MW9 C38 C39  sing N N 327 
MW9 P   O2   sing N N 328 
MW9 P   O3   sing N N 329 
MW9 P   O5   sing N N 330 
MW9 C24 C25  sing N N 331 
MW9 C24 O8   sing N N 332 
MW9 O2  C20  sing N N 333 
MW9 O8  C19  sing N N 334 
MW9 O5  C21  sing N N 335 
MW9 C21 C22  sing N N 336 
MW9 C39 C40  sing N N 337 
MW9 C20 C19  sing N N 338 
MW9 C19 C18  sing N N 339 
MW9 O7  C22  sing N N 340 
MW9 C40 C41  sing N N 341 
MW9 C22 C23  sing N N 342 
MW9 C16 C15  sing N N 343 
MW9 C16 C17  sing N N 344 
MW9 O6  C23  sing N N 345 
MW9 C18 O1   sing N N 346 
MW9 C15 C14  sing N N 347 
MW9 C17 O1   sing N N 348 
MW9 C17 O    doub N N 349 
MW9 C14 C13  sing N N 350 
MW9 C2  C3   sing N N 351 
MW9 C2  C1   sing N N 352 
MW9 C4  C3   sing N N 353 
MW9 C4  C5   sing N N 354 
MW9 C13 C12  sing N N 355 
MW9 C   C1   sing N N 356 
MW9 C5  C6   sing N N 357 
MW9 C12 C11  sing N N 358 
MW9 C6  C7   sing N N 359 
MW9 C9  C10  sing N N 360 
MW9 C9  C8   sing N N 361 
MW9 C10 C11  sing N N 362 
MW9 C7  C8   sing N N 363 
MW9 C   H1   sing N N 364 
MW9 C   H2   sing N N 365 
MW9 C   H3   sing N N 366 
MW9 C1  H4   sing N N 367 
MW9 C1  H5   sing N N 368 
MW9 C10 H6   sing N N 369 
MW9 C10 H7   sing N N 370 
MW9 C11 H8   sing N N 371 
MW9 C11 H9   sing N N 372 
MW9 C12 H10  sing N N 373 
MW9 C12 H11  sing N N 374 
MW9 C13 H12  sing N N 375 
MW9 C13 H13  sing N N 376 
MW9 C14 H14  sing N N 377 
MW9 C14 H15  sing N N 378 
MW9 C15 H16  sing N N 379 
MW9 C15 H17  sing N N 380 
MW9 C16 H18  sing N N 381 
MW9 C16 H19  sing N N 382 
MW9 C18 H20  sing N N 383 
MW9 C18 H21  sing N N 384 
MW9 C19 H22  sing N N 385 
MW9 C2  H23  sing N N 386 
MW9 C2  H24  sing N N 387 
MW9 C20 H25  sing N N 388 
MW9 C20 H26  sing N N 389 
MW9 C21 H27  sing N N 390 
MW9 C21 H28  sing N N 391 
MW9 C22 H29  sing N N 392 
MW9 C23 H30  sing N N 393 
MW9 C23 H31  sing N N 394 
MW9 C25 H32  sing N N 395 
MW9 C25 H33  sing N N 396 
MW9 C26 H34  sing N N 397 
MW9 C26 H35  sing N N 398 
MW9 C27 H36  sing N N 399 
MW9 C27 H37  sing N N 400 
MW9 C28 H38  sing N N 401 
MW9 C28 H39  sing N N 402 
MW9 C29 H40  sing N N 403 
MW9 C29 H41  sing N N 404 
MW9 C3  H42  sing N N 405 
MW9 C3  H43  sing N N 406 
MW9 C30 H44  sing N N 407 
MW9 C30 H45  sing N N 408 
MW9 C31 H46  sing N N 409 
MW9 C31 H47  sing N N 410 
MW9 C32 H48  sing N N 411 
MW9 C33 H49  sing N N 412 
MW9 C34 H50  sing N N 413 
MW9 C34 H51  sing N N 414 
MW9 C35 H52  sing N N 415 
MW9 C35 H53  sing N N 416 
MW9 C36 H54  sing N N 417 
MW9 C36 H55  sing N N 418 
MW9 C37 H56  sing N N 419 
MW9 C37 H57  sing N N 420 
MW9 C38 H58  sing N N 421 
MW9 C38 H59  sing N N 422 
MW9 C39 H60  sing N N 423 
MW9 C39 H61  sing N N 424 
MW9 C4  H62  sing N N 425 
MW9 C4  H63  sing N N 426 
MW9 C40 H64  sing N N 427 
MW9 C40 H65  sing N N 428 
MW9 C41 H66  sing N N 429 
MW9 C41 H67  sing N N 430 
MW9 C41 H68  sing N N 431 
MW9 C5  H69  sing N N 432 
MW9 C5  H70  sing N N 433 
MW9 C6  H71  sing N N 434 
MW9 C6  H72  sing N N 435 
MW9 C7  H73  sing N N 436 
MW9 C7  H74  sing N N 437 
MW9 C8  H75  sing N N 438 
MW9 C8  H76  sing N N 439 
MW9 C9  H77  sing N N 440 
MW9 C9  H78  sing N N 441 
MW9 O3  H79  sing N N 442 
MW9 O6  H80  sing N N 443 
MW9 O7  H81  sing N N 444 
PHE N   CA   sing N N 445 
PHE N   H    sing N N 446 
PHE N   H2   sing N N 447 
PHE CA  C    sing N N 448 
PHE CA  CB   sing N N 449 
PHE CA  HA   sing N N 450 
PHE C   O    doub N N 451 
PHE C   OXT  sing N N 452 
PHE CB  CG   sing N N 453 
PHE CB  HB2  sing N N 454 
PHE CB  HB3  sing N N 455 
PHE CG  CD1  doub Y N 456 
PHE CG  CD2  sing Y N 457 
PHE CD1 CE1  sing Y N 458 
PHE CD1 HD1  sing N N 459 
PHE CD2 CE2  doub Y N 460 
PHE CD2 HD2  sing N N 461 
PHE CE1 CZ   doub Y N 462 
PHE CE1 HE1  sing N N 463 
PHE CE2 CZ   sing Y N 464 
PHE CE2 HE2  sing N N 465 
PHE CZ  HZ   sing N N 466 
PHE OXT HXT  sing N N 467 
PRO N   CA   sing N N 468 
PRO N   CD   sing N N 469 
PRO N   H    sing N N 470 
PRO CA  C    sing N N 471 
PRO CA  CB   sing N N 472 
PRO CA  HA   sing N N 473 
PRO C   O    doub N N 474 
PRO C   OXT  sing N N 475 
PRO CB  CG   sing N N 476 
PRO CB  HB2  sing N N 477 
PRO CB  HB3  sing N N 478 
PRO CG  CD   sing N N 479 
PRO CG  HG2  sing N N 480 
PRO CG  HG3  sing N N 481 
PRO CD  HD2  sing N N 482 
PRO CD  HD3  sing N N 483 
PRO OXT HXT  sing N N 484 
SER N   CA   sing N N 485 
SER N   H    sing N N 486 
SER N   H2   sing N N 487 
SER CA  C    sing N N 488 
SER CA  CB   sing N N 489 
SER CA  HA   sing N N 490 
SER C   O    doub N N 491 
SER C   OXT  sing N N 492 
SER CB  OG   sing N N 493 
SER CB  HB2  sing N N 494 
SER CB  HB3  sing N N 495 
SER OG  HG   sing N N 496 
SER OXT HXT  sing N N 497 
THR N   CA   sing N N 498 
THR N   H    sing N N 499 
THR N   H2   sing N N 500 
THR CA  C    sing N N 501 
THR CA  CB   sing N N 502 
THR CA  HA   sing N N 503 
THR C   O    doub N N 504 
THR C   OXT  sing N N 505 
THR CB  OG1  sing N N 506 
THR CB  CG2  sing N N 507 
THR CB  HB   sing N N 508 
THR OG1 HG1  sing N N 509 
THR CG2 HG21 sing N N 510 
THR CG2 HG22 sing N N 511 
THR CG2 HG23 sing N N 512 
THR OXT HXT  sing N N 513 
TRP N   CA   sing N N 514 
TRP N   H    sing N N 515 
TRP N   H2   sing N N 516 
TRP CA  C    sing N N 517 
TRP CA  CB   sing N N 518 
TRP CA  HA   sing N N 519 
TRP C   O    doub N N 520 
TRP C   OXT  sing N N 521 
TRP CB  CG   sing N N 522 
TRP CB  HB2  sing N N 523 
TRP CB  HB3  sing N N 524 
TRP CG  CD1  doub Y N 525 
TRP CG  CD2  sing Y N 526 
TRP CD1 NE1  sing Y N 527 
TRP CD1 HD1  sing N N 528 
TRP CD2 CE2  doub Y N 529 
TRP CD2 CE3  sing Y N 530 
TRP NE1 CE2  sing Y N 531 
TRP NE1 HE1  sing N N 532 
TRP CE2 CZ2  sing Y N 533 
TRP CE3 CZ3  doub Y N 534 
TRP CE3 HE3  sing N N 535 
TRP CZ2 CH2  doub Y N 536 
TRP CZ2 HZ2  sing N N 537 
TRP CZ3 CH2  sing Y N 538 
TRP CZ3 HZ3  sing N N 539 
TRP CH2 HH2  sing N N 540 
TRP OXT HXT  sing N N 541 
TYR N   CA   sing N N 542 
TYR N   H    sing N N 543 
TYR N   H2   sing N N 544 
TYR CA  C    sing N N 545 
TYR CA  CB   sing N N 546 
TYR CA  HA   sing N N 547 
TYR C   O    doub N N 548 
TYR C   OXT  sing N N 549 
TYR CB  CG   sing N N 550 
TYR CB  HB2  sing N N 551 
TYR CB  HB3  sing N N 552 
TYR CG  CD1  doub Y N 553 
TYR CG  CD2  sing Y N 554 
TYR CD1 CE1  sing Y N 555 
TYR CD1 HD1  sing N N 556 
TYR CD2 CE2  doub Y N 557 
TYR CD2 HD2  sing N N 558 
TYR CE1 CZ   doub Y N 559 
TYR CE1 HE1  sing N N 560 
TYR CE2 CZ   sing Y N 561 
TYR CE2 HE2  sing N N 562 
TYR CZ  OH   sing N N 563 
TYR OH  HH   sing N N 564 
TYR OXT HXT  sing N N 565 
VAL N   CA   sing N N 566 
VAL N   H    sing N N 567 
VAL N   H2   sing N N 568 
VAL CA  C    sing N N 569 
VAL CA  CB   sing N N 570 
VAL CA  HA   sing N N 571 
VAL C   O    doub N N 572 
VAL C   OXT  sing N N 573 
VAL CB  CG1  sing N N 574 
VAL CB  CG2  sing N N 575 
VAL CB  HB   sing N N 576 
VAL CG1 HG11 sing N N 577 
VAL CG1 HG12 sing N N 578 
VAL CG1 HG13 sing N N 579 
VAL CG2 HG21 sing N N 580 
VAL CG2 HG22 sing N N 581 
VAL CG2 HG23 sing N N 582 
VAL OXT HXT  sing N N 583 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-03-02 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8YJP 
_em_admin.last_update        2025-02-05 
_em_admin.map_release_date   2025-02-05 
_em_admin.title              'Cryo-EM structure of human apo GPR156' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   1 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         52 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8YJP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ARG A 1 22  ? 119.887 129.898 165.496 1.00 131.00 ? 22  ARG A N   1 
ATOM   2    C CA  . ARG A 1 22  ? 119.195 128.690 165.063 1.00 131.00 ? 22  ARG A CA  1 
ATOM   3    C C   . ARG A 1 22  ? 119.852 127.443 165.645 1.00 131.00 ? 22  ARG A C   1 
ATOM   4    O O   . ARG A 1 22  ? 121.068 127.277 165.555 1.00 131.00 ? 22  ARG A O   1 
ATOM   5    C CB  . ARG A 1 22  ? 119.167 128.605 163.536 1.00 131.00 ? 22  ARG A CB  1 
ATOM   6    N N   . PRO A 1 23  ? 119.043 126.564 166.247 1.00 131.11 ? 23  PRO A N   1 
ATOM   7    C CA  . PRO A 1 23  ? 119.588 125.313 166.795 1.00 131.11 ? 23  PRO A CA  1 
ATOM   8    C C   . PRO A 1 23  ? 120.102 124.355 165.729 1.00 131.11 ? 23  PRO A C   1 
ATOM   9    O O   . PRO A 1 23  ? 120.561 123.254 166.051 1.00 131.11 ? 23  PRO A O   1 
ATOM   10   C CB  . PRO A 1 23  ? 118.394 124.717 167.551 1.00 131.11 ? 23  PRO A CB  1 
ATOM   11   N N   . LEU A 1 24  ? 120.025 124.758 164.458 1.00 128.60 ? 24  LEU A N   1 
ATOM   12   C CA  . LEU A 1 24  ? 120.508 123.902 163.379 1.00 128.60 ? 24  LEU A CA  1 
ATOM   13   C C   . LEU A 1 24  ? 122.014 123.691 163.474 1.00 128.60 ? 24  LEU A C   1 
ATOM   14   O O   . LEU A 1 24  ? 122.509 122.583 163.236 1.00 128.60 ? 24  LEU A O   1 
ATOM   15   C CB  . LEU A 1 24  ? 120.133 124.505 162.026 1.00 128.60 ? 24  LEU A CB  1 
ATOM   16   N N   . HIS A 1 25  ? 122.760 124.745 163.817 1.00 129.28 ? 25  HIS A N   1 
ATOM   17   C CA  . HIS A 1 25  ? 124.209 124.617 163.941 1.00 129.28 ? 25  HIS A CA  1 
ATOM   18   C C   . HIS A 1 25  ? 124.582 123.660 165.066 1.00 129.28 ? 25  HIS A C   1 
ATOM   19   O O   . HIS A 1 25  ? 125.560 122.912 164.957 1.00 129.28 ? 25  HIS A O   1 
ATOM   20   C CB  . HIS A 1 25  ? 124.840 125.990 164.171 1.00 129.28 ? 25  HIS A CB  1 
ATOM   21   N N   . ASP A 1 26  ? 123.855 123.714 166.181 1.00 130.57 ? 26  ASP A N   1 
ATOM   22   C CA  . ASP A 1 26  ? 124.152 122.824 167.298 1.00 130.57 ? 26  ASP A CA  1 
ATOM   23   C C   . ASP A 1 26  ? 123.970 121.362 166.902 1.00 130.57 ? 26  ASP A C   1 
ATOM   24   O O   . ASP A 1 26  ? 124.852 120.526 167.133 1.00 130.57 ? 26  ASP A O   1 
ATOM   25   C CB  . ASP A 1 26  ? 123.267 123.174 168.495 1.00 130.57 ? 26  ASP A CB  1 
ATOM   26   N N   . LEU A 1 27  ? 122.821 121.037 166.303 1.00 128.58 ? 27  LEU A N   1 
ATOM   27   C CA  . LEU A 1 27  ? 122.571 119.682 165.816 1.00 128.58 ? 27  LEU A CA  1 
ATOM   28   C C   . LEU A 1 27  ? 123.505 119.263 164.684 1.00 128.58 ? 27  LEU A C   1 
ATOM   29   O O   . LEU A 1 27  ? 123.710 118.060 164.478 1.00 128.58 ? 27  LEU A O   1 
ATOM   30   C CB  . LEU A 1 27  ? 121.116 119.556 165.363 1.00 128.58 ? 27  LEU A CB  1 
ATOM   31   N N   . CYS A 1 28  ? 124.047 120.216 163.919 1.00 126.68 ? 28  CYS A N   1 
ATOM   32   C CA  . CYS A 1 28  ? 125.171 119.923 163.031 1.00 126.68 ? 28  CYS A CA  1 
ATOM   33   C C   . CYS A 1 28  ? 126.207 119.035 163.711 1.00 126.68 ? 28  CYS A C   1 
ATOM   34   O O   . CYS A 1 28  ? 126.401 117.884 163.308 1.00 126.68 ? 28  CYS A O   1 
ATOM   35   C CB  . CYS A 1 28  ? 125.825 121.211 162.529 1.00 126.68 ? 28  CYS A CB  1 
ATOM   36   N N   . LYS A 1 29  ? 126.881 119.560 164.736 1.00 128.20 ? 29  LYS A N   1 
ATOM   37   C CA  . LYS A 1 29  ? 127.933 118.791 165.389 1.00 128.20 ? 29  LYS A CA  1 
ATOM   38   C C   . LYS A 1 29  ? 127.381 117.587 166.141 1.00 128.20 ? 29  LYS A C   1 
ATOM   39   O O   . LYS A 1 29  ? 128.128 116.637 166.401 1.00 128.20 ? 29  LYS A O   1 
ATOM   40   C CB  . LYS A 1 29  ? 128.723 119.685 166.345 1.00 128.20 ? 29  LYS A CB  1 
ATOM   41   N N   . THR A 1 30  ? 126.093 117.607 166.495 1.00 129.57 ? 30  THR A N   1 
ATOM   42   C CA  . THR A 1 30  ? 125.480 116.461 167.159 1.00 129.57 ? 30  THR A CA  1 
ATOM   43   C C   . THR A 1 30  ? 125.372 115.269 166.217 1.00 129.57 ? 30  THR A C   1 
ATOM   44   O O   . THR A 1 30  ? 125.556 114.120 166.635 1.00 129.57 ? 30  THR A O   1 
ATOM   45   C CB  . THR A 1 30  ? 124.103 116.841 167.702 1.00 129.57 ? 30  THR A CB  1 
ATOM   46   N N   . THR A 1 31  ? 125.073 115.524 164.944 1.00 127.61 ? 31  THR A N   1 
ATOM   47   C CA  . THR A 1 31  ? 125.020 114.461 163.949 1.00 127.61 ? 31  THR A CA  1 
ATOM   48   C C   . THR A 1 31  ? 126.391 114.112 163.387 1.00 127.61 ? 31  THR A C   1 
ATOM   49   O O   . THR A 1 31  ? 126.547 113.036 162.799 1.00 127.61 ? 31  THR A O   1 
ATOM   50   C CB  . THR A 1 31  ? 124.083 114.852 162.804 1.00 127.61 ? 31  THR A CB  1 
ATOM   51   N N   . ILE A 1 32  ? 127.382 114.992 163.554 1.00 127.97 ? 32  ILE A N   1 
ATOM   52   C CA  . ILE A 1 32  ? 128.728 114.695 163.074 1.00 127.97 ? 32  ILE A CA  1 
ATOM   53   C C   . ILE A 1 32  ? 129.325 113.514 163.826 1.00 127.97 ? 32  ILE A C   1 
ATOM   54   O O   . ILE A 1 32  ? 130.087 112.726 163.252 1.00 127.97 ? 32  ILE A O   1 
ATOM   55   C CB  . ILE A 1 32  ? 129.622 115.944 163.186 1.00 127.97 ? 32  ILE A CB  1 
ATOM   56   N N   . THR A 1 33  ? 129.004 113.372 165.114 1.00 128.44 ? 33  THR A N   1 
ATOM   57   C CA  . THR A 1 33  ? 129.479 112.217 165.870 1.00 128.44 ? 33  THR A CA  1 
ATOM   58   C C   . THR A 1 33  ? 128.897 110.927 165.305 1.00 128.44 ? 33  THR A C   1 
ATOM   59   O O   . THR A 1 33  ? 129.608 109.929 165.141 1.00 128.44 ? 33  THR A O   1 
ATOM   60   C CB  . THR A 1 33  ? 129.119 112.370 167.348 1.00 128.44 ? 33  THR A CB  1 
ATOM   61   N N   . SER A 1 34  ? 127.607 110.948 164.990 1.00 129.09 ? 34  SER A N   1 
ATOM   62   C CA  . SER A 1 34  ? 126.971 109.774 164.405 1.00 129.09 ? 34  SER A CA  1 
ATOM   63   C C   . SER A 1 34  ? 127.344 109.651 162.937 1.00 129.09 ? 34  SER A C   1 
ATOM   64   O O   . SER A 1 34  ? 126.958 108.690 162.272 1.00 129.09 ? 34  SER A O   1 
ATOM   65   C CB  . SER A 1 34  ? 125.452 109.855 164.557 1.00 129.09 ? 34  SER A CB  1 
ATOM   66   N N   . SER A 1 35  ? 128.098 110.620 162.429 1.00 128.17 ? 35  SER A N   1 
ATOM   67   C CA  . SER A 1 35  ? 128.505 110.594 161.027 1.00 128.17 ? 35  SER A CA  1 
ATOM   68   C C   . SER A 1 35  ? 129.856 109.921 160.864 1.00 128.17 ? 35  SER A C   1 
ATOM   69   O O   . SER A 1 35  ? 130.456 109.976 159.790 1.00 128.17 ? 35  SER A O   1 
ATOM   70   C CB  . SER A 1 35  ? 128.562 112.011 160.461 1.00 128.17 ? 35  SER A CB  1 
ATOM   71   N N   . HIS A 1 36  ? 130.338 109.284 161.924 1.00 127.87 ? 36  HIS A N   1 
ATOM   72   C CA  . HIS A 1 36  ? 131.640 108.632 161.871 1.00 127.87 ? 36  HIS A CA  1 
ATOM   73   C C   . HIS A 1 36  ? 131.690 107.602 160.751 1.00 127.87 ? 36  HIS A C   1 
ATOM   74   O O   . HIS A 1 36  ? 132.701 107.482 160.060 1.00 127.87 ? 36  HIS A O   1 
ATOM   75   C CB  . HIS A 1 36  ? 131.957 107.965 163.210 1.00 127.87 ? 36  HIS A CB  1 
ATOM   76   N N   . HIS A 1 37  ? 130.603 106.861 160.568 1.00 125.19 ? 37  HIS A N   1 
ATOM   77   C CA  . HIS A 1 37  ? 130.567 105.834 159.531 1.00 125.19 ? 37  HIS A CA  1 
ATOM   78   C C   . HIS A 1 37  ? 129.630 106.210 158.393 1.00 125.19 ? 37  HIS A C   1 
ATOM   79   O O   . HIS A 1 37  ? 128.901 107.198 158.485 1.00 125.19 ? 37  HIS A O   1 
ATOM   80   C CB  . HIS A 1 37  ? 130.146 104.490 160.128 1.00 125.19 ? 37  HIS A CB  1 
ATOM   81   N N   . SER A 1 38  ? 129.646 105.425 157.320 1.00 115.72 ? 38  SER A N   1 
ATOM   82   C CA  . SER A 1 38  ? 128.778 105.693 156.184 1.00 115.72 ? 38  SER A CA  1 
ATOM   83   C C   . SER A 1 38  ? 128.595 104.415 155.380 1.00 115.72 ? 38  SER A C   1 
ATOM   84   O O   . SER A 1 38  ? 129.445 103.521 155.405 1.00 115.72 ? 38  SER A O   1 
ATOM   85   C CB  . SER A 1 38  ? 129.344 106.804 155.288 1.00 115.72 ? 38  SER A CB  1 
ATOM   86   N N   . SER A 1 39  ? 127.472 104.336 154.670 1.00 107.28 ? 39  SER A N   1 
ATOM   87   C CA  . SER A 1 39  ? 127.175 103.155 153.872 1.00 107.28 ? 39  SER A CA  1 
ATOM   88   C C   . SER A 1 39  ? 128.186 103.000 152.743 1.00 107.28 ? 39  SER A C   1 
ATOM   89   O O   . SER A 1 39  ? 128.574 103.975 152.093 1.00 107.28 ? 39  SER A O   1 
ATOM   90   C CB  . SER A 1 39  ? 125.759 103.243 153.303 1.00 107.28 ? 39  SER A CB  1 
ATOM   91   N N   . LYS A 1 40  ? 128.613 101.760 152.512 1.00 102.77 ? 40  LYS A N   1 
ATOM   92   C CA  . LYS A 1 40  ? 129.578 101.442 151.469 1.00 102.77 ? 40  LYS A CA  1 
ATOM   93   C C   . LYS A 1 40  ? 128.923 100.973 150.177 1.00 102.77 ? 40  LYS A C   1 
ATOM   94   O O   . LYS A 1 40  ? 129.639 100.648 149.224 1.00 102.77 ? 40  LYS A O   1 
ATOM   95   C CB  . LYS A 1 40  ? 130.559 100.375 151.966 1.00 102.77 ? 40  LYS A CB  1 
ATOM   96   N N   . THR A 1 41  ? 127.588 100.900 150.143 1.00 95.91  ? 41  THR A N   1 
ATOM   97   C CA  . THR A 1 41  ? 126.803 100.491 148.979 1.00 95.91  ? 41  THR A CA  1 
ATOM   98   C C   . THR A 1 41  ? 126.968 99.002  148.691 1.00 95.91  ? 41  THR A C   1 
ATOM   99   O O   . THR A 1 41  ? 128.012 98.412  148.985 1.00 95.91  ? 41  THR A O   1 
ATOM   100  C CB  . THR A 1 41  ? 127.166 101.317 147.739 1.00 95.91  ? 41  THR A CB  1 
ATOM   101  N N   . ILE A 1 42  ? 125.934 98.387  148.115 1.00 86.58  ? 42  ILE A N   1 
ATOM   102  C CA  . ILE A 1 42  ? 125.939 96.966  147.800 1.00 86.58  ? 42  ILE A CA  1 
ATOM   103  C C   . ILE A 1 42  ? 125.462 96.784  146.366 1.00 86.58  ? 42  ILE A C   1 
ATOM   104  O O   . ILE A 1 42  ? 124.862 97.678  145.766 1.00 86.58  ? 42  ILE A O   1 
ATOM   105  C CB  . ILE A 1 42  ? 125.059 96.147  148.769 1.00 86.58  ? 42  ILE A CB  1 
ATOM   106  N N   . SER A 1 43  ? 125.738 95.603  145.819 1.00 78.61  ? 43  SER A N   1 
ATOM   107  C CA  . SER A 1 43  ? 125.347 95.282  144.455 1.00 78.61  ? 43  SER A CA  1 
ATOM   108  C C   . SER A 1 43  ? 123.909 94.785  144.421 1.00 78.61  ? 43  SER A C   1 
ATOM   109  O O   . SER A 1 43  ? 123.508 93.945  145.232 1.00 78.61  ? 43  SER A O   1 
ATOM   110  C CB  . SER A 1 43  ? 126.280 94.226  143.861 1.00 78.61  ? 43  SER A CB  1 
ATOM   111  O OG  . SER A 1 43  ? 125.914 93.915  142.528 1.00 78.61  ? 43  SER A OG  1 
ATOM   112  N N   . SER A 1 44  ? 123.136 95.312  143.474 1.00 70.70  ? 44  SER A N   1 
ATOM   113  C CA  . SER A 1 44  ? 121.744 94.911  143.314 1.00 70.70  ? 44  SER A CA  1 
ATOM   114  C C   . SER A 1 44  ? 121.374 94.818  141.840 1.00 70.70  ? 44  SER A C   1 
ATOM   115  O O   . SER A 1 44  ? 120.231 95.095  141.463 1.00 70.70  ? 44  SER A O   1 
ATOM   116  C CB  . SER A 1 44  ? 120.818 95.890  144.038 1.00 70.70  ? 44  SER A CB  1 
ATOM   117  O OG  . SER A 1 44  ? 121.006 97.213  143.568 1.00 70.70  ? 44  SER A OG  1 
ATOM   118  N N   . LEU A 1 45  ? 122.329 94.431  141.000 1.00 59.30  ? 45  LEU A N   1 
ATOM   119  C CA  . LEU A 1 45  ? 122.087 94.223  139.579 1.00 59.30  ? 45  LEU A CA  1 
ATOM   120  C C   . LEU A 1 45  ? 121.810 92.744  139.342 1.00 59.30  ? 45  LEU A C   1 
ATOM   121  O O   . LEU A 1 45  ? 122.667 91.897  139.616 1.00 59.30  ? 45  LEU A O   1 
ATOM   122  C CB  . LEU A 1 45  ? 123.279 94.695  138.748 1.00 59.30  ? 45  LEU A CB  1 
ATOM   123  C CG  . LEU A 1 45  ? 123.013 95.016  137.277 1.00 59.30  ? 45  LEU A CG  1 
ATOM   124  C CD1 . LEU A 1 45  ? 121.788 95.897  137.128 1.00 59.30  ? 45  LEU A CD1 1 
ATOM   125  C CD2 . LEU A 1 45  ? 124.229 95.681  136.656 1.00 59.30  ? 45  LEU A CD2 1 
ATOM   126  N N   . SER A 1 46  ? 120.613 92.440  138.848 1.00 54.17  ? 46  SER A N   1 
ATOM   127  C CA  . SER A 1 46  ? 120.193 91.055  138.690 1.00 54.17  ? 46  SER A CA  1 
ATOM   128  C C   . SER A 1 46  ? 121.106 90.329  137.707 1.00 54.17  ? 46  SER A C   1 
ATOM   129  O O   . SER A 1 46  ? 121.408 90.868  136.633 1.00 54.17  ? 46  SER A O   1 
ATOM   130  C CB  . SER A 1 46  ? 118.745 90.986  138.210 1.00 54.17  ? 46  SER A CB  1 
ATOM   131  O OG  . SER A 1 46  ? 118.600 91.590  136.938 1.00 54.17  ? 46  SER A OG  1 
ATOM   132  N N   . PRO A 1 47  ? 121.574 89.121  138.039 1.00 51.81  ? 47  PRO A N   1 
ATOM   133  C CA  . PRO A 1 47  ? 122.460 88.393  137.113 1.00 51.81  ? 47  PRO A CA  1 
ATOM   134  C C   . PRO A 1 47  ? 121.838 88.117  135.756 1.00 51.81  ? 47  PRO A C   1 
ATOM   135  O O   . PRO A 1 47  ? 122.523 88.240  134.734 1.00 51.81  ? 47  PRO A O   1 
ATOM   136  C CB  . PRO A 1 47  ? 122.765 87.096  137.875 1.00 51.81  ? 47  PRO A CB  1 
ATOM   137  C CG  . PRO A 1 47  ? 121.651 86.954  138.855 1.00 51.81  ? 47  PRO A CG  1 
ATOM   138  C CD  . PRO A 1 47  ? 121.284 88.345  139.254 1.00 51.81  ? 47  PRO A CD  1 
ATOM   139  N N   . VAL A 1 48  ? 120.573 87.696  135.724 1.00 50.89  ? 48  VAL A N   1 
ATOM   140  C CA  . VAL A 1 48  ? 119.913 87.371  134.462 1.00 50.89  ? 48  VAL A CA  1 
ATOM   141  C C   . VAL A 1 48  ? 119.974 88.548  133.494 1.00 50.89  ? 48  VAL A C   1 
ATOM   142  O O   . VAL A 1 48  ? 120.259 88.376  132.300 1.00 50.89  ? 48  VAL A O   1 
ATOM   143  C CB  . VAL A 1 48  ? 118.462 86.931  134.727 1.00 50.89  ? 48  VAL A CB  1 
ATOM   144  C CG1 . VAL A 1 48  ? 117.753 86.613  133.423 1.00 50.89  ? 48  VAL A CG1 1 
ATOM   145  C CG2 . VAL A 1 48  ? 118.435 85.736  135.665 1.00 50.89  ? 48  VAL A CG2 1 
ATOM   146  N N   . LEU A 1 49  ? 119.698 89.760  133.986 1.00 51.05  ? 49  LEU A N   1 
ATOM   147  C CA  . LEU A 1 49  ? 119.749 90.938  133.125 1.00 51.05  ? 49  LEU A CA  1 
ATOM   148  C C   . LEU A 1 49  ? 121.156 91.177  132.596 1.00 51.05  ? 49  LEU A C   1 
ATOM   149  O O   . LEU A 1 49  ? 121.336 91.503  131.416 1.00 51.05  ? 49  LEU A O   1 
ATOM   150  C CB  . LEU A 1 49  ? 119.244 92.165  133.881 1.00 51.05  ? 49  LEU A CB  1 
ATOM   151  C CG  . LEU A 1 49  ? 119.039 93.436  133.059 1.00 51.05  ? 49  LEU A CG  1 
ATOM   152  C CD1 . LEU A 1 49  ? 118.307 93.129  131.769 1.00 51.05  ? 49  LEU A CD1 1 
ATOM   153  C CD2 . LEU A 1 49  ? 118.284 94.473  133.869 1.00 51.05  ? 49  LEU A CD2 1 
ATOM   154  N N   . LEU A 1 50  ? 122.166 91.019  133.456 1.00 52.45  ? 50  LEU A N   1 
ATOM   155  C CA  . LEU A 1 50  ? 123.548 91.162  133.012 1.00 52.45  ? 50  LEU A CA  1 
ATOM   156  C C   . LEU A 1 50  ? 123.871 90.161  131.914 1.00 52.45  ? 50  LEU A C   1 
ATOM   157  O O   . LEU A 1 50  ? 124.495 90.511  130.907 1.00 52.45  ? 50  LEU A O   1 
ATOM   158  C CB  . LEU A 1 50  ? 124.503 90.992  134.191 1.00 52.45  ? 50  LEU A CB  1 
ATOM   159  C CG  . LEU A 1 50  ? 124.753 92.225  135.060 1.00 52.45  ? 50  LEU A CG  1 
ATOM   160  C CD1 . LEU A 1 50  ? 125.245 91.816  136.439 1.00 52.45  ? 50  LEU A CD1 1 
ATOM   161  C CD2 . LEU A 1 50  ? 125.752 93.153  134.388 1.00 52.45  ? 50  LEU A CD2 1 
ATOM   162  N N   . GLY A 1 51  ? 123.450 88.910  132.091 1.00 49.64  ? 51  GLY A N   1 
ATOM   163  C CA  . GLY A 1 51  ? 123.708 87.905  131.076 1.00 49.64  ? 51  GLY A CA  1 
ATOM   164  C C   . GLY A 1 51  ? 123.042 88.232  129.756 1.00 49.64  ? 51  GLY A C   1 
ATOM   165  O O   . GLY A 1 51  ? 123.659 88.115  128.694 1.00 49.64  ? 51  GLY A O   1 
ATOM   166  N N   . ILE A 1 52  ? 121.779 88.659  129.803 1.00 51.28  ? 52  ILE A N   1 
ATOM   167  C CA  . ILE A 1 52  ? 121.054 88.959  128.570 1.00 51.28  ? 52  ILE A CA  1 
ATOM   168  C C   . ILE A 1 52  ? 121.698 90.132  127.840 1.00 51.28  ? 52  ILE A C   1 
ATOM   169  O O   . ILE A 1 52  ? 121.906 90.090  126.618 1.00 51.28  ? 52  ILE A O   1 
ATOM   170  C CB  . ILE A 1 52  ? 119.570 89.230  128.869 1.00 51.28  ? 52  ILE A CB  1 
ATOM   171  C CG1 . ILE A 1 52  ? 118.912 87.987  129.459 1.00 51.28  ? 52  ILE A CG1 1 
ATOM   172  C CG2 . ILE A 1 52  ? 118.844 89.653  127.605 1.00 51.28  ? 52  ILE A CG2 1 
ATOM   173  C CD1 . ILE A 1 52  ? 117.647 88.282  130.221 1.00 51.28  ? 52  ILE A CD1 1 
ATOM   174  N N   . VAL A 1 53  ? 122.031 91.195  128.575 1.00 51.57  ? 53  VAL A N   1 
ATOM   175  C CA  . VAL A 1 53  ? 122.598 92.369  127.919 1.00 51.57  ? 53  VAL A CA  1 
ATOM   176  C C   . VAL A 1 53  ? 123.992 92.065  127.384 1.00 51.57  ? 53  VAL A C   1 
ATOM   177  O O   . VAL A 1 53  ? 124.359 92.518  126.293 1.00 51.57  ? 53  VAL A O   1 
ATOM   178  C CB  . VAL A 1 53  ? 122.595 93.584  128.864 1.00 51.57  ? 53  VAL A CB  1 
ATOM   179  C CG1 . VAL A 1 53  ? 121.174 93.924  129.288 1.00 51.57  ? 53  VAL A CG1 1 
ATOM   180  C CG2 . VAL A 1 53  ? 123.470 93.334  130.065 1.00 51.57  ? 53  VAL A CG2 1 
ATOM   181  N N   . TRP A 1 54  ? 124.789 91.291  128.129 1.00 52.21  ? 54  TRP A N   1 
ATOM   182  C CA  . TRP A 1 54  ? 126.105 90.911  127.633 1.00 52.21  ? 54  TRP A CA  1 
ATOM   183  C C   . TRP A 1 54  ? 125.988 90.053  126.385 1.00 52.21  ? 54  TRP A C   1 
ATOM   184  O O   . TRP A 1 54  ? 126.773 90.209  125.446 1.00 52.21  ? 54  TRP A O   1 
ATOM   185  C CB  . TRP A 1 54  ? 126.893 90.183  128.718 1.00 52.21  ? 54  TRP A CB  1 
ATOM   186  C CG  . TRP A 1 54  ? 127.430 91.098  129.766 1.00 52.21  ? 54  TRP A CG  1 
ATOM   187  C CD1 . TRP A 1 54  ? 127.433 92.459  129.738 1.00 52.21  ? 54  TRP A CD1 1 
ATOM   188  C CD2 . TRP A 1 54  ? 128.046 90.720  131.002 1.00 52.21  ? 54  TRP A CD2 1 
ATOM   189  N NE1 . TRP A 1 54  ? 128.012 92.955  130.880 1.00 52.21  ? 54  TRP A NE1 1 
ATOM   190  C CE2 . TRP A 1 54  ? 128.396 91.907  131.673 1.00 52.21  ? 54  TRP A CE2 1 
ATOM   191  C CE3 . TRP A 1 54  ? 128.333 89.493  131.607 1.00 52.21  ? 54  TRP A CE3 1 
ATOM   192  C CZ2 . TRP A 1 54  ? 129.021 91.905  132.917 1.00 52.21  ? 54  TRP A CZ2 1 
ATOM   193  C CZ3 . TRP A 1 54  ? 128.953 89.492  132.843 1.00 52.21  ? 54  TRP A CZ3 1 
ATOM   194  C CH2 . TRP A 1 54  ? 129.290 90.690  133.485 1.00 52.21  ? 54  TRP A CH2 1 
ATOM   195  N N   . THR A 1 55  ? 125.006 89.150  126.347 1.00 51.14  ? 55  THR A N   1 
ATOM   196  C CA  . THR A 1 55  ? 124.795 88.337  125.155 1.00 51.14  ? 55  THR A CA  1 
ATOM   197  C C   . THR A 1 55  ? 124.448 89.204  123.953 1.00 51.14  ? 55  THR A C   1 
ATOM   198  O O   . THR A 1 55  ? 124.998 89.020  122.859 1.00 51.14  ? 55  THR A O   1 
ATOM   199  C CB  . THR A 1 55  ? 123.690 87.313  125.407 1.00 51.14  ? 55  THR A CB  1 
ATOM   200  O OG1 . THR A 1 55  ? 124.003 86.545  126.575 1.00 51.14  ? 55  THR A OG1 1 
ATOM   201  C CG2 . THR A 1 55  ? 123.549 86.384  124.212 1.00 51.14  ? 55  THR A CG2 1 
ATOM   202  N N   . PHE A 1 56  ? 123.529 90.154  124.133 1.00 50.30  ? 56  PHE A N   1 
ATOM   203  C CA  . PHE A 1 56  ? 123.110 90.970  122.997 1.00 50.30  ? 56  PHE A CA  1 
ATOM   204  C C   . PHE A 1 56  ? 124.239 91.872  122.515 1.00 50.30  ? 56  PHE A C   1 
ATOM   205  O O   . PHE A 1 56  ? 124.459 92.014  121.303 1.00 50.30  ? 56  PHE A O   1 
ATOM   206  C CB  . PHE A 1 56  ? 121.873 91.785  123.360 1.00 50.30  ? 56  PHE A CB  1 
ATOM   207  C CG  . PHE A 1 56  ? 120.584 91.066  123.089 1.00 50.30  ? 56  PHE A CG  1 
ATOM   208  C CD1 . PHE A 1 56  ? 120.045 90.206  124.030 1.00 50.30  ? 56  PHE A CD1 1 
ATOM   209  C CD2 . PHE A 1 56  ? 119.922 91.235  121.885 1.00 50.30  ? 56  PHE A CD2 1 
ATOM   210  C CE1 . PHE A 1 56  ? 118.865 89.537  123.781 1.00 50.30  ? 56  PHE A CE1 1 
ATOM   211  C CE2 . PHE A 1 56  ? 118.739 90.569  121.631 1.00 50.30  ? 56  PHE A CE2 1 
ATOM   212  C CZ  . PHE A 1 56  ? 118.211 89.719  122.580 1.00 50.30  ? 56  PHE A CZ  1 
ATOM   213  N N   . LEU A 1 57  ? 124.982 92.472  123.445 1.00 49.17  ? 57  LEU A N   1 
ATOM   214  C CA  . LEU A 1 57  ? 126.121 93.289  123.051 1.00 49.17  ? 57  LEU A CA  1 
ATOM   215  C C   . LEU A 1 57  ? 127.220 92.450  122.417 1.00 49.17  ? 57  LEU A C   1 
ATOM   216  O O   . LEU A 1 57  ? 127.929 92.936  121.534 1.00 49.17  ? 57  LEU A O   1 
ATOM   217  C CB  . LEU A 1 57  ? 126.654 94.059  124.254 1.00 49.17  ? 57  LEU A CB  1 
ATOM   218  C CG  . LEU A 1 57  ? 125.690 95.068  124.874 1.00 49.17  ? 57  LEU A CG  1 
ATOM   219  C CD1 . LEU A 1 57  ? 126.159 95.464  126.262 1.00 49.17  ? 57  LEU A CD1 1 
ATOM   220  C CD2 . LEU A 1 57  ? 125.550 96.287  123.982 1.00 49.17  ? 57  LEU A CD2 1 
ATOM   221  N N   . SER A 1 58  ? 127.387 91.198  122.852 1.00 49.19  ? 58  SER A N   1 
ATOM   222  C CA  . SER A 1 58  ? 128.377 90.329  122.228 1.00 49.19  ? 58  SER A CA  1 
ATOM   223  C C   . SER A 1 58  ? 127.977 89.978  120.804 1.00 49.19  ? 58  SER A C   1 
ATOM   224  O O   . SER A 1 58  ? 128.830 89.920  119.913 1.00 49.19  ? 58  SER A O   1 
ATOM   225  C CB  . SER A 1 58  ? 128.563 89.064  123.063 1.00 49.19  ? 58  SER A CB  1 
ATOM   226  O OG  . SER A 1 58  ? 127.384 88.279  123.064 1.00 49.19  ? 58  SER A OG  1 
ATOM   227  N N   . CYS A 1 59  ? 126.685 89.739  120.572 1.00 50.02  ? 59  CYS A N   1 
ATOM   228  C CA  . CYS A 1 59  ? 126.212 89.535  119.206 1.00 50.02  ? 59  CYS A CA  1 
ATOM   229  C C   . CYS A 1 59  ? 126.461 90.775  118.354 1.00 50.02  ? 59  CYS A C   1 
ATOM   230  O O   . CYS A 1 59  ? 126.901 90.674  117.200 1.00 50.02  ? 59  CYS A O   1 
ATOM   231  C CB  . CYS A 1 59  ? 124.729 89.174  119.211 1.00 50.02  ? 59  CYS A CB  1 
ATOM   232  S SG  . CYS A 1 59  ? 124.356 87.598  120.007 1.00 50.02  ? 59  CYS A SG  1 
ATOM   233  N N   . GLY A 1 60  ? 126.191 91.957  118.913 1.00 48.89  ? 60  GLY A N   1 
ATOM   234  C CA  . GLY A 1 60  ? 126.479 93.186  118.190 1.00 48.89  ? 60  GLY A CA  1 
ATOM   235  C C   . GLY A 1 60  ? 127.953 93.354  117.873 1.00 48.89  ? 60  GLY A C   1 
ATOM   236  O O   . GLY A 1 60  ? 128.316 93.777  116.774 1.00 48.89  ? 60  GLY A O   1 
ATOM   237  N N   . LEU A 1 61  ? 128.822 93.029  118.832 1.00 47.98  ? 61  LEU A N   1 
ATOM   238  C CA  . LEU A 1 61  ? 130.260 93.119  118.596 1.00 47.98  ? 61  LEU A CA  1 
ATOM   239  C C   . LEU A 1 61  ? 130.713 92.116  117.547 1.00 47.98  ? 61  LEU A C   1 
ATOM   240  O O   . LEU A 1 61  ? 131.604 92.413  116.744 1.00 47.98  ? 61  LEU A O   1 
ATOM   241  C CB  . LEU A 1 61  ? 131.029 92.912  119.897 1.00 47.98  ? 61  LEU A CB  1 
ATOM   242  C CG  . LEU A 1 61  ? 131.372 94.191  120.655 1.00 47.98  ? 61  LEU A CG  1 
ATOM   243  C CD1 . LEU A 1 61  ? 132.079 93.866  121.946 1.00 47.98  ? 61  LEU A CD1 1 
ATOM   244  C CD2 . LEU A 1 61  ? 132.228 95.095  119.791 1.00 47.98  ? 61  LEU A CD2 1 
ATOM   245  N N   . LEU A 1 62  ? 130.131 90.917  117.551 1.00 49.62  ? 62  LEU A N   1 
ATOM   246  C CA  . LEU A 1 62  ? 130.422 89.959  116.492 1.00 49.62  ? 62  LEU A CA  1 
ATOM   247  C C   . LEU A 1 62  ? 130.015 90.514  115.136 1.00 49.62  ? 62  LEU A C   1 
ATOM   248  O O   . LEU A 1 62  ? 130.735 90.347  114.146 1.00 49.62  ? 62  LEU A O   1 
ATOM   249  C CB  . LEU A 1 62  ? 129.712 88.635  116.768 1.00 49.62  ? 62  LEU A CB  1 
ATOM   250  C CG  . LEU A 1 62  ? 130.436 87.657  117.692 1.00 49.62  ? 62  LEU A CG  1 
ATOM   251  C CD1 . LEU A 1 62  ? 129.533 86.488  118.050 1.00 49.62  ? 62  LEU A CD1 1 
ATOM   252  C CD2 . LEU A 1 62  ? 131.719 87.168  117.045 1.00 49.62  ? 62  LEU A CD2 1 
ATOM   253  N N   . LEU A 1 63  ? 128.869 91.194  115.075 1.00 49.37  ? 63  LEU A N   1 
ATOM   254  C CA  . LEU A 1 63  ? 128.452 91.832  113.829 1.00 49.37  ? 63  LEU A CA  1 
ATOM   255  C C   . LEU A 1 63  ? 129.438 92.913  113.396 1.00 49.37  ? 63  LEU A C   1 
ATOM   256  O O   . LEU A 1 63  ? 129.773 93.025  112.209 1.00 49.37  ? 63  LEU A O   1 
ATOM   257  C CB  . LEU A 1 63  ? 127.052 92.421  113.989 1.00 49.37  ? 63  LEU A CB  1 
ATOM   258  C CG  . LEU A 1 63  ? 126.416 93.001  112.727 1.00 49.37  ? 63  LEU A CG  1 
ATOM   259  C CD1 . LEU A 1 63  ? 126.077 91.895  111.740 1.00 49.37  ? 63  LEU A CD1 1 
ATOM   260  C CD2 . LEU A 1 63  ? 125.179 93.813  113.075 1.00 49.37  ? 63  LEU A CD2 1 
ATOM   261  N N   . ILE A 1 64  ? 129.906 93.724  114.345 1.00 48.32  ? 64  ILE A N   1 
ATOM   262  C CA  . ILE A 1 64  ? 130.847 94.795  114.021 1.00 48.32  ? 64  ILE A CA  1 
ATOM   263  C C   . ILE A 1 64  ? 132.159 94.218  113.511 1.00 48.32  ? 64  ILE A C   1 
ATOM   264  O O   . ILE A 1 64  ? 132.735 94.711  112.534 1.00 48.32  ? 64  ILE A O   1 
ATOM   265  C CB  . ILE A 1 64  ? 131.072 95.697  115.246 1.00 48.32  ? 64  ILE A CB  1 
ATOM   266  C CG1 . ILE A 1 64  ? 129.749 96.301  115.700 1.00 48.32  ? 64  ILE A CG1 1 
ATOM   267  C CG2 . ILE A 1 64  ? 132.089 96.783  114.940 1.00 48.32  ? 64  ILE A CG2 1 
ATOM   268  C CD1 . ILE A 1 64  ? 129.097 97.155  114.665 1.00 48.32  ? 64  ILE A CD1 1 
ATOM   269  N N   . LEU A 1 65  ? 132.657 93.174  114.174 1.00 46.79  ? 65  LEU A N   1 
ATOM   270  C CA  . LEU A 1 65  ? 133.886 92.525  113.735 1.00 46.79  ? 65  LEU A CA  1 
ATOM   271  C C   . LEU A 1 65  ? 133.705 91.883  112.367 1.00 46.79  ? 65  LEU A C   1 
ATOM   272  O O   . LEU A 1 65  ? 134.626 91.887  111.542 1.00 46.79  ? 65  LEU A O   1 
ATOM   273  C CB  . LEU A 1 65  ? 134.317 91.491  114.771 1.00 46.79  ? 65  LEU A CB  1 
ATOM   274  C CG  . LEU A 1 65  ? 134.722 92.076  116.124 1.00 46.79  ? 65  LEU A CG  1 
ATOM   275  C CD1 . LEU A 1 65  ? 134.998 90.975  117.132 1.00 46.79  ? 65  LEU A CD1 1 
ATOM   276  C CD2 . LEU A 1 65  ? 135.932 92.986  115.972 1.00 46.79  ? 65  LEU A CD2 1 
ATOM   277  N N   . PHE A 1 66  ? 132.520 91.328  112.107 1.00 47.24  ? 66  PHE A N   1 
ATOM   278  C CA  . PHE A 1 66  ? 132.224 90.782  110.790 1.00 47.24  ? 66  PHE A CA  1 
ATOM   279  C C   . PHE A 1 66  ? 132.268 91.868  109.725 1.00 47.24  ? 66  PHE A C   1 
ATOM   280  O O   . PHE A 1 66  ? 132.792 91.649  108.629 1.00 47.24  ? 66  PHE A O   1 
ATOM   281  C CB  . PHE A 1 66  ? 130.857 90.099  110.812 1.00 47.24  ? 66  PHE A CB  1 
ATOM   282  C CG  . PHE A 1 66  ? 130.239 89.927  109.458 1.00 47.24  ? 66  PHE A CG  1 
ATOM   283  C CD1 . PHE A 1 66  ? 130.813 89.088  108.522 1.00 47.24  ? 66  PHE A CD1 1 
ATOM   284  C CD2 . PHE A 1 66  ? 129.075 90.594  109.124 1.00 47.24  ? 66  PHE A CD2 1 
ATOM   285  C CE1 . PHE A 1 66  ? 130.244 88.923  107.278 1.00 47.24  ? 66  PHE A CE1 1 
ATOM   286  C CE2 . PHE A 1 66  ? 128.502 90.434  107.880 1.00 47.24  ? 66  PHE A CE2 1 
ATOM   287  C CZ  . PHE A 1 66  ? 129.088 89.597  106.956 1.00 47.24  ? 66  PHE A CZ  1 
ATOM   288  N N   . PHE A 1 67  ? 131.724 93.047  110.030 1.00 47.51  ? 67  PHE A N   1 
ATOM   289  C CA  . PHE A 1 67  ? 131.767 94.146  109.070 1.00 47.51  ? 67  PHE A CA  1 
ATOM   290  C C   . PHE A 1 67  ? 133.195 94.634  108.848 1.00 47.51  ? 67  PHE A C   1 
ATOM   291  O O   . PHE A 1 67  ? 133.582 94.954  107.715 1.00 47.51  ? 67  PHE A O   1 
ATOM   292  C CB  . PHE A 1 67  ? 130.877 95.290  109.548 1.00 47.51  ? 67  PHE A CB  1 
ATOM   293  C CG  . PHE A 1 67  ? 129.408 95.002  109.441 1.00 47.51  ? 67  PHE A CG  1 
ATOM   294  C CD1 . PHE A 1 67  ? 128.931 94.094  108.512 1.00 47.51  ? 67  PHE A CD1 1 
ATOM   295  C CD2 . PHE A 1 67  ? 128.503 95.642  110.268 1.00 47.51  ? 67  PHE A CD2 1 
ATOM   296  C CE1 . PHE A 1 67  ? 127.582 93.830  108.414 1.00 47.51  ? 67  PHE A CE1 1 
ATOM   297  C CE2 . PHE A 1 67  ? 127.152 95.379  110.171 1.00 47.51  ? 67  PHE A CE2 1 
ATOM   298  C CZ  . PHE A 1 67  ? 126.693 94.471  109.242 1.00 47.51  ? 67  PHE A CZ  1 
ATOM   299  N N   . LEU A 1 68  ? 133.989 94.699  109.920 1.00 50.07  ? 68  LEU A N   1 
ATOM   300  C CA  . LEU A 1 68  ? 135.398 95.058  109.793 1.00 50.07  ? 68  LEU A CA  1 
ATOM   301  C C   . LEU A 1 68  ? 136.126 94.085  108.879 1.00 50.07  ? 68  LEU A C   1 
ATOM   302  O O   . LEU A 1 68  ? 136.871 94.492  107.980 1.00 50.07  ? 68  LEU A O   1 
ATOM   303  C CB  . LEU A 1 68  ? 136.063 95.076  111.171 1.00 50.07  ? 68  LEU A CB  1 
ATOM   304  C CG  . LEU A 1 68  ? 136.078 96.363  111.993 1.00 50.07  ? 68  LEU A CG  1 
ATOM   305  C CD1 . LEU A 1 68  ? 136.336 96.049  113.457 1.00 50.07  ? 68  LEU A CD1 1 
ATOM   306  C CD2 . LEU A 1 68  ? 137.124 97.326  111.462 1.00 50.07  ? 68  LEU A CD2 1 
ATOM   307  N N   . ALA A 1 69  ? 135.919 92.785  109.101 1.00 51.08  ? 69  ALA A N   1 
ATOM   308  C CA  . ALA A 1 69  ? 136.563 91.776  108.270 1.00 51.08  ? 69  ALA A CA  1 
ATOM   309  C C   . ALA A 1 69  ? 136.079 91.859  106.830 1.00 51.08  ? 69  ALA A C   1 
ATOM   310  O O   . ALA A 1 69  ? 136.866 91.688  105.895 1.00 51.08  ? 69  ALA A O   1 
ATOM   311  C CB  . ALA A 1 69  ? 136.308 90.383  108.844 1.00 51.08  ? 69  ALA A CB  1 
ATOM   312  N N   . PHE A 1 70  ? 134.787 92.114  106.634 1.00 51.49  ? 70  PHE A N   1 
ATOM   313  C CA  . PHE A 1 70  ? 134.246 92.260  105.288 1.00 51.49  ? 70  PHE A CA  1 
ATOM   314  C C   . PHE A 1 70  ? 134.930 93.399  104.545 1.00 51.49  ? 70  PHE A C   1 
ATOM   315  O O   . PHE A 1 70  ? 135.378 93.230  103.407 1.00 51.49  ? 70  PHE A O   1 
ATOM   316  C CB  . PHE A 1 70  ? 132.734 92.478  105.365 1.00 51.49  ? 70  PHE A CB  1 
ATOM   317  C CG  . PHE A 1 70  ? 132.123 93.000  104.098 1.00 51.49  ? 70  PHE A CG  1 
ATOM   318  C CD1 . PHE A 1 70  ? 132.360 92.376  102.886 1.00 51.49  ? 70  PHE A CD1 1 
ATOM   319  C CD2 . PHE A 1 70  ? 131.292 94.104  104.124 1.00 51.49  ? 70  PHE A CD2 1 
ATOM   320  C CE1 . PHE A 1 70  ? 131.794 92.856  101.723 1.00 51.49  ? 70  PHE A CE1 1 
ATOM   321  C CE2 . PHE A 1 70  ? 130.723 94.587  102.965 1.00 51.49  ? 70  PHE A CE2 1 
ATOM   322  C CZ  . PHE A 1 70  ? 130.974 93.962  101.763 1.00 51.49  ? 70  PHE A CZ  1 
ATOM   323  N N   . THR A 1 71  ? 135.014 94.573  105.172 1.00 51.95  ? 71  THR A N   1 
ATOM   324  C CA  . THR A 1 71  ? 135.636 95.714  104.504 1.00 51.95  ? 71  THR A CA  1 
ATOM   325  C C   . THR A 1 71  ? 137.136 95.523  104.310 1.00 51.95  ? 71  THR A C   1 
ATOM   326  O O   . THR A 1 71  ? 137.689 95.984  103.307 1.00 51.95  ? 71  THR A O   1 
ATOM   327  C CB  . THR A 1 71  ? 135.363 96.997  105.282 1.00 51.95  ? 71  THR A CB  1 
ATOM   328  O OG1 . THR A 1 71  ? 135.641 96.780  106.670 1.00 51.95  ? 71  THR A OG1 1 
ATOM   329  C CG2 . THR A 1 71  ? 133.915 97.424  105.112 1.00 51.95  ? 71  THR A CG2 1 
ATOM   330  N N   . ILE A 1 72  ? 137.815 94.868  105.256 1.00 55.93  ? 72  ILE A N   1 
ATOM   331  C CA  . ILE A 1 72  ? 139.240 94.599  105.088 1.00 55.93  ? 72  ILE A CA  1 
ATOM   332  C C   . ILE A 1 72  ? 139.481 93.625  103.940 1.00 55.93  ? 72  ILE A C   1 
ATOM   333  O O   . ILE A 1 72  ? 140.368 93.836  103.105 1.00 55.93  ? 72  ILE A O   1 
ATOM   334  C CB  . ILE A 1 72  ? 139.839 94.081  106.408 1.00 55.93  ? 72  ILE A CB  1 
ATOM   335  C CG1 . ILE A 1 72  ? 140.018 95.231  107.400 1.00 55.93  ? 72  ILE A CG1 1 
ATOM   336  C CG2 . ILE A 1 72  ? 141.167 93.380  106.160 1.00 55.93  ? 72  ILE A CG2 1 
ATOM   337  C CD1 . ILE A 1 72  ? 140.359 94.780  108.802 1.00 55.93  ? 72  ILE A CD1 1 
ATOM   338  N N   . HIS A 1 73  ? 138.689 92.552  103.867 1.00 58.30  ? 73  HIS A N   1 
ATOM   339  C CA  . HIS A 1 73  ? 138.893 91.545  102.834 1.00 58.30  ? 73  HIS A CA  1 
ATOM   340  C C   . HIS A 1 73  ? 138.436 92.032  101.469 1.00 58.30  ? 73  HIS A C   1 
ATOM   341  O O   . HIS A 1 73  ? 138.982 91.606  100.445 1.00 58.30  ? 73  HIS A O   1 
ATOM   342  C CB  . HIS A 1 73  ? 138.161 90.256  103.211 1.00 58.30  ? 73  HIS A CB  1 
ATOM   343  C CG  . HIS A 1 73  ? 138.496 89.091  102.334 1.00 58.30  ? 73  HIS A CG  1 
ATOM   344  N ND1 . HIS A 1 73  ? 139.533 88.226  102.609 1.00 58.30  ? 73  HIS A ND1 1 
ATOM   345  C CD2 . HIS A 1 73  ? 137.930 88.646  101.187 1.00 58.30  ? 73  HIS A CD2 1 
ATOM   346  C CE1 . HIS A 1 73  ? 139.592 87.299  101.670 1.00 58.30  ? 73  HIS A CE1 1 
ATOM   347  N NE2 . HIS A 1 73  ? 138.630 87.532  100.795 1.00 58.30  ? 73  HIS A NE2 1 
ATOM   348  N N   . CYS A 1 74  ? 137.444 92.911  101.429 1.00 58.59  ? 74  CYS A N   1 
ATOM   349  C CA  . CYS A 1 74  ? 136.934 93.476  100.186 1.00 58.59  ? 74  CYS A CA  1 
ATOM   350  C C   . CYS A 1 74  ? 137.412 94.920  100.114 1.00 58.59  ? 74  CYS A C   1 
ATOM   351  O O   . CYS A 1 74  ? 136.828 95.809  100.738 1.00 58.59  ? 74  CYS A O   1 
ATOM   352  C CB  . CYS A 1 74  ? 135.412 93.382  100.123 1.00 58.59  ? 74  CYS A CB  1 
ATOM   353  S SG  . CYS A 1 74  ? 134.768 91.692  100.139 1.00 58.59  ? 74  CYS A SG  1 
ATOM   354  N N   . ARG A 1 75  ? 138.489 95.144  99.368  1.00 63.61  ? 75  ARG A N   1 
ATOM   355  C CA  . ARG A 1 75  ? 138.979 96.483  99.099  1.00 63.61  ? 75  ARG A CA  1 
ATOM   356  C C   . ARG A 1 75  ? 139.160 96.735  97.612  1.00 63.61  ? 75  ARG A C   1 
ATOM   357  O O   . ARG A 1 75  ? 139.618 97.818  97.234  1.00 63.61  ? 75  ARG A O   1 
ATOM   358  C CB  . ARG A 1 75  ? 140.307 96.733  99.830  1.00 63.61  ? 75  ARG A CB  1 
ATOM   359  C CG  . ARG A 1 75  ? 141.325 95.612  99.684  1.00 63.61  ? 75  ARG A CG  1 
ATOM   360  C CD  . ARG A 1 75  ? 142.742 96.126  99.889  1.00 63.61  ? 75  ARG A CD  1 
ATOM   361  N NE  . ARG A 1 75  ? 143.731 95.057  99.828  1.00 63.61  ? 75  ARG A NE  1 
ATOM   362  C CZ  . ARG A 1 75  ? 144.312 94.637  98.712  1.00 63.61  ? 75  ARG A CZ  1 
ATOM   363  N NH1 . ARG A 1 75  ? 144.024 95.176  97.538  1.00 63.61  ? 75  ARG A NH1 1 
ATOM   364  N NH2 . ARG A 1 75  ? 145.204 93.653  98.775  1.00 63.61  ? 75  ARG A NH2 1 
ATOM   365  N N   . LYS A 1 76  ? 138.813 95.769  96.763  1.00 65.68  ? 76  LYS A N   1 
ATOM   366  C CA  . LYS A 1 76  ? 138.911 95.915  95.321  1.00 65.68  ? 76  LYS A CA  1 
ATOM   367  C C   . LYS A 1 76  ? 137.557 95.944  94.629  1.00 65.68  ? 76  LYS A C   1 
ATOM   368  O O   . LYS A 1 76  ? 137.498 96.265  93.438  1.00 65.68  ? 76  LYS A O   1 
ATOM   369  C CB  . LYS A 1 76  ? 139.758 94.779  94.726  1.00 65.68  ? 76  LYS A CB  1 
ATOM   370  C CG  . LYS A 1 76  ? 141.249 94.907  94.997  1.00 65.68  ? 76  LYS A CG  1 
ATOM   371  C CD  . LYS A 1 76  ? 141.877 95.990  94.135  1.00 65.68  ? 76  LYS A CD  1 
ATOM   372  C CE  . LYS A 1 76  ? 143.395 95.927  94.188  1.00 65.68  ? 76  LYS A CE  1 
ATOM   373  N NZ  . LYS A 1 76  ? 144.026 96.904  93.259  1.00 65.68  ? 76  LYS A NZ  1 
ATOM   374  N N   . ASN A 1 77  ? 136.478 95.609  95.330  1.00 61.91  ? 77  ASN A N   1 
ATOM   375  C CA  . ASN A 1 77  ? 135.153 95.681  94.734  1.00 61.91  ? 77  ASN A CA  1 
ATOM   376  C C   . ASN A 1 77  ? 134.747 97.136  94.544  1.00 61.91  ? 77  ASN A C   1 
ATOM   377  O O   . ASN A 1 77  ? 135.205 98.030  95.260  1.00 61.91  ? 77  ASN A O   1 
ATOM   378  C CB  . ASN A 1 77  ? 134.133 94.954  95.608  1.00 61.91  ? 77  ASN A CB  1 
ATOM   379  C CG  . ASN A 1 77  ? 132.864 94.610  94.857  1.00 61.91  ? 77  ASN A CG  1 
ATOM   380  O OD1 . ASN A 1 77  ? 132.045 95.481  94.565  1.00 61.91  ? 77  ASN A OD1 1 
ATOM   381  N ND2 . ASN A 1 77  ? 132.693 93.332  94.539  1.00 61.91  ? 77  ASN A ND2 1 
ATOM   382  N N   . ARG A 1 78  ? 133.879 97.377  93.559  1.00 60.07  ? 78  ARG A N   1 
ATOM   383  C CA  . ARG A 1 78  ? 133.517 98.755  93.253  1.00 60.07  ? 78  ARG A CA  1 
ATOM   384  C C   . ARG A 1 78  ? 132.612 99.353  94.321  1.00 60.07  ? 78  ARG A C   1 
ATOM   385  O O   . ARG A 1 78  ? 132.685 100.559 94.585  1.00 60.07  ? 78  ARG A O   1 
ATOM   386  C CB  . ARG A 1 78  ? 132.843 98.824  91.884  1.00 60.07  ? 78  ARG A CB  1 
ATOM   387  C CG  . ARG A 1 78  ? 132.654 100.234 91.355  1.00 60.07  ? 78  ARG A CG  1 
ATOM   388  C CD  . ARG A 1 78  ? 132.225 100.223 89.897  1.00 60.07  ? 78  ARG A CD  1 
ATOM   389  N NE  . ARG A 1 78  ? 133.296 99.773  89.014  1.00 60.07  ? 78  ARG A NE  1 
ATOM   390  C CZ  . ARG A 1 78  ? 133.145 99.529  87.720  1.00 60.07  ? 78  ARG A CZ  1 
ATOM   391  N NH1 . ARG A 1 78  ? 131.976 99.680  87.119  1.00 60.07  ? 78  ARG A NH1 1 
ATOM   392  N NH2 . ARG A 1 78  ? 134.194 99.122  87.010  1.00 60.07  ? 78  ARG A NH2 1 
ATOM   393  N N   . ILE A 1 79  ? 131.782 98.530  94.969  1.00 57.14  ? 79  ILE A N   1 
ATOM   394  C CA  . ILE A 1 79  ? 131.000 99.020  96.099  1.00 57.14  ? 79  ILE A CA  1 
ATOM   395  C C   . ILE A 1 79  ? 131.925 99.488  97.211  1.00 57.14  ? 79  ILE A C   1 
ATOM   396  O O   . ILE A 1 79  ? 131.624 100.459 97.920  1.00 57.14  ? 79  ILE A O   1 
ATOM   397  C CB  . ILE A 1 79  ? 130.026 97.933  96.587  1.00 57.14  ? 79  ILE A CB  1 
ATOM   398  C CG1 . ILE A 1 79  ? 129.273 97.327  95.402  1.00 57.14  ? 79  ILE A CG1 1 
ATOM   399  C CG2 . ILE A 1 79  ? 129.046 98.510  97.592  1.00 57.14  ? 79  ILE A CG2 1 
ATOM   400  C CD1 . ILE A 1 79  ? 128.511 98.340  94.578  1.00 57.14  ? 79  ILE A CD1 1 
ATOM   401  N N   . VAL A 1 80  ? 133.067 98.819  97.370  1.00 58.34  ? 80  VAL A N   1 
ATOM   402  C CA  . VAL A 1 80  ? 134.055 99.240  98.357  1.00 58.34  ? 80  VAL A CA  1 
ATOM   403  C C   . VAL A 1 80  ? 134.578 100.631 98.021  1.00 58.34  ? 80  VAL A C   1 
ATOM   404  O O   . VAL A 1 80  ? 134.629 101.516 98.882  1.00 58.34  ? 80  VAL A O   1 
ATOM   405  C CB  . VAL A 1 80  ? 135.197 98.215  98.448  1.00 58.34  ? 80  VAL A CB  1 
ATOM   406  C CG1 . VAL A 1 80  ? 136.169 98.625  99.535  1.00 58.34  ? 80  VAL A CG1 1 
ATOM   407  C CG2 . VAL A 1 80  ? 134.637 96.828  98.707  1.00 58.34  ? 80  VAL A CG2 1 
ATOM   408  N N   . LYS A 1 81  ? 134.967 100.848 96.759  1.00 58.92  ? 81  LYS A N   1 
ATOM   409  C CA  . LYS A 1 81  ? 135.455 102.166 96.367  1.00 58.92  ? 81  LYS A CA  1 
ATOM   410  C C   . LYS A 1 81  ? 134.376 103.221 96.545  1.00 58.92  ? 81  LYS A C   1 
ATOM   411  O O   . LYS A 1 81  ? 134.683 104.383 96.837  1.00 58.92  ? 81  LYS A O   1 
ATOM   412  C CB  . LYS A 1 81  ? 135.946 102.165 94.918  1.00 58.92  ? 81  LYS A CB  1 
ATOM   413  C CG  . LYS A 1 81  ? 137.386 101.715 94.734  1.00 58.92  ? 81  LYS A CG  1 
ATOM   414  C CD  . LYS A 1 81  ? 137.484 100.218 94.527  1.00 58.92  ? 81  LYS A CD  1 
ATOM   415  C CE  . LYS A 1 81  ? 137.002 99.854  93.132  1.00 58.92  ? 81  LYS A CE  1 
ATOM   416  N NZ  . LYS A 1 81  ? 137.193 98.416  92.815  1.00 58.92  ? 81  LYS A NZ  1 
ATOM   417  N N   . MET A 1 82  ? 133.113 102.840 96.376  1.00 55.23  ? 82  MET A N   1 
ATOM   418  C CA  . MET A 1 82  ? 132.040 103.822 96.414  1.00 55.23  ? 82  MET A CA  1 
ATOM   419  C C   . MET A 1 82  ? 131.726 104.214 97.849  1.00 55.23  ? 82  MET A C   1 
ATOM   420  O O   . MET A 1 82  ? 131.437 105.382 98.127  1.00 55.23  ? 82  MET A O   1 
ATOM   421  C CB  . MET A 1 82  ? 130.795 103.290 95.708  1.00 55.23  ? 82  MET A CB  1 
ATOM   422  C CG  . MET A 1 82  ? 130.979 103.083 94.219  1.00 55.23  ? 82  MET A CG  1 
ATOM   423  S SD  . MET A 1 82  ? 131.383 104.618 93.368  1.00 55.23  ? 82  MET A SD  1 
ATOM   424  C CE  . MET A 1 82  ? 129.833 105.502 93.514  1.00 55.23  ? 82  MET A CE  1 
ATOM   425  N N   . SER A 1 83  ? 131.789 103.259 98.774  1.00 49.06  ? 83  SER A N   1 
ATOM   426  C CA  . SER A 1 83  ? 131.303 103.461 100.129 1.00 49.06  ? 83  SER A CA  1 
ATOM   427  C C   . SER A 1 83  ? 132.413 103.840 101.103 1.00 49.06  ? 83  SER A C   1 
ATOM   428  O O   . SER A 1 83  ? 132.180 103.841 102.315 1.00 49.06  ? 83  SER A O   1 
ATOM   429  C CB  . SER A 1 83  ? 130.588 102.204 100.620 1.00 49.06  ? 83  SER A CB  1 
ATOM   430  O OG  . SER A 1 83  ? 129.463 101.910 99.814  1.00 49.06  ? 83  SER A OG  1 
ATOM   431  N N   . SER A 1 84  ? 133.616 104.155 100.599 1.00 47.27  ? 84  SER A N   1 
ATOM   432  C CA  . SER A 1 84  ? 134.708 104.721 101.389 1.00 47.27  ? 84  SER A CA  1 
ATOM   433  C C   . SER A 1 84  ? 135.089 103.818 102.557 1.00 47.27  ? 84  SER A C   1 
ATOM   434  O O   . SER A 1 84  ? 134.760 104.125 103.709 1.00 47.27  ? 84  SER A O   1 
ATOM   435  C CB  . SER A 1 84  ? 134.337 106.115 101.894 1.00 47.27  ? 84  SER A CB  1 
ATOM   436  O OG  . SER A 1 84  ? 134.529 107.085 100.880 1.00 47.27  ? 84  SER A OG  1 
ATOM   437  N N   . PRO A 1 85  ? 135.769 102.698 102.300 1.00 44.75  ? 85  PRO A N   1 
ATOM   438  C CA  . PRO A 1 85  ? 135.982 101.711 103.368 1.00 44.75  ? 85  PRO A CA  1 
ATOM   439  C C   . PRO A 1 85  ? 136.759 102.235 104.561 1.00 44.75  ? 85  PRO A C   1 
ATOM   440  O O   . PRO A 1 85  ? 136.533 101.760 105.677 1.00 44.75  ? 85  PRO A O   1 
ATOM   441  C CB  . PRO A 1 85  ? 136.744 100.593 102.649 1.00 44.75  ? 85  PRO A CB  1 
ATOM   442  C CG  . PRO A 1 85  ? 137.472 101.294 101.567 1.00 44.75  ? 85  PRO A CG  1 
ATOM   443  C CD  . PRO A 1 85  ? 136.567 102.393 101.103 1.00 44.75  ? 85  PRO A CD  1 
ATOM   444  N N   . ASN A 1 86  ? 137.686 103.175 104.366 1.00 47.65  ? 86  ASN A N   1 
ATOM   445  C CA  . ASN A 1 86  ? 138.482 103.669 105.488 1.00 47.65  ? 86  ASN A CA  1 
ATOM   446  C C   . ASN A 1 86  ? 137.609 104.391 106.508 1.00 47.65  ? 86  ASN A C   1 
ATOM   447  O O   . ASN A 1 86  ? 137.735 104.176 107.724 1.00 47.65  ? 86  ASN A O   1 
ATOM   448  C CB  . ASN A 1 86  ? 139.577 104.599 104.973 1.00 47.65  ? 86  ASN A CB  1 
ATOM   449  C CG  . ASN A 1 86  ? 140.441 103.950 103.915 1.00 47.65  ? 86  ASN A CG  1 
ATOM   450  O OD1 . ASN A 1 86  ? 140.890 102.815 104.073 1.00 47.65  ? 86  ASN A OD1 1 
ATOM   451  N ND2 . ASN A 1 86  ? 140.668 104.664 102.819 1.00 47.65  ? 86  ASN A ND2 1 
ATOM   452  N N   . LEU A 1 87  ? 136.710 105.252 106.026 1.00 45.01  ? 87  LEU A N   1 
ATOM   453  C CA  . LEU A 1 87  ? 135.796 105.945 106.923 1.00 45.01  ? 87  LEU A CA  1 
ATOM   454  C C   . LEU A 1 87  ? 134.864 104.961 107.613 1.00 45.01  ? 87  LEU A C   1 
ATOM   455  O O   . LEU A 1 87  ? 134.472 105.171 108.768 1.00 45.01  ? 87  LEU A O   1 
ATOM   456  C CB  . LEU A 1 87  ? 135.005 106.997 106.146 1.00 45.01  ? 87  LEU A CB  1 
ATOM   457  C CG  . LEU A 1 87  ? 135.667 108.360 105.899 1.00 45.01  ? 87  LEU A CG  1 
ATOM   458  C CD1 . LEU A 1 87  ? 135.930 109.100 107.199 1.00 45.01  ? 87  LEU A CD1 1 
ATOM   459  C CD2 . LEU A 1 87  ? 136.942 108.241 105.083 1.00 45.01  ? 87  LEU A CD2 1 
ATOM   460  N N   . ASN A 1 88  ? 134.528 103.862 106.937 1.00 44.16  ? 88  ASN A N   1 
ATOM   461  C CA  . ASN A 1 88  ? 133.723 102.826 107.567 1.00 44.16  ? 88  ASN A CA  1 
ATOM   462  C C   . ASN A 1 88  ? 134.508 102.086 108.642 1.00 44.16  ? 88  ASN A C   1 
ATOM   463  O O   . ASN A 1 88  ? 133.930 101.671 109.650 1.00 44.16  ? 88  ASN A O   1 
ATOM   464  C CB  . ASN A 1 88  ? 133.203 101.858 106.509 1.00 44.16  ? 88  ASN A CB  1 
ATOM   465  C CG  . ASN A 1 88  ? 132.275 102.528 105.517 1.00 44.16  ? 88  ASN A CG  1 
ATOM   466  O OD1 . ASN A 1 88  ? 131.663 103.550 105.817 1.00 44.16  ? 88  ASN A OD1 1 
ATOM   467  N ND2 . ASN A 1 88  ? 132.165 101.953 104.326 1.00 44.16  ? 88  ASN A ND2 1 
ATOM   468  N N   . ILE A 1 89  ? 135.819 101.915 108.452 1.00 45.11  ? 89  ILE A N   1 
ATOM   469  C CA  . ILE A 1 89  ? 136.658 101.363 109.514 1.00 45.11  ? 89  ILE A CA  1 
ATOM   470  C C   . ILE A 1 89  ? 136.646 102.287 110.721 1.00 45.11  ? 89  ILE A C   1 
ATOM   471  O O   . ILE A 1 89  ? 136.579 101.837 111.872 1.00 45.11  ? 89  ILE A O   1 
ATOM   472  C CB  . ILE A 1 89  ? 138.091 101.120 109.008 1.00 45.11  ? 89  ILE A CB  1 
ATOM   473  C CG1 . ILE A 1 89  ? 138.092 100.155 107.826 1.00 45.11  ? 89  ILE A CG1 1 
ATOM   474  C CG2 . ILE A 1 89  ? 138.957 100.562 110.123 1.00 45.11  ? 89  ILE A CG2 1 
ATOM   475  C CD1 . ILE A 1 89  ? 137.541 98.795  108.156 1.00 45.11  ? 89  ILE A CD1 1 
ATOM   476  N N   . VAL A 1 90  ? 136.728 103.595 110.476 1.00 42.68  ? 90  VAL A N   1 
ATOM   477  C CA  . VAL A 1 90  ? 136.653 104.559 111.572 1.00 42.68  ? 90  VAL A CA  1 
ATOM   478  C C   . VAL A 1 90  ? 135.318 104.432 112.300 1.00 42.68  ? 90  VAL A C   1 
ATOM   479  O O   . VAL A 1 90  ? 135.257 104.449 113.540 1.00 42.68  ? 90  VAL A O   1 
ATOM   480  C CB  . VAL A 1 90  ? 136.878 105.985 111.043 1.00 42.68  ? 90  VAL A CB  1 
ATOM   481  C CG1 . VAL A 1 90  ? 136.839 106.975 112.177 1.00 42.68  ? 90  VAL A CG1 1 
ATOM   482  C CG2 . VAL A 1 90  ? 138.203 106.069 110.310 1.00 42.68  ? 90  VAL A CG2 1 
ATOM   483  N N   . THR A 1 91  ? 134.230 104.294 111.541 1.00 42.04  ? 91  THR A N   1 
ATOM   484  C CA  . THR A 1 91  ? 132.912 104.141 112.147 1.00 42.04  ? 91  THR A CA  1 
ATOM   485  C C   . THR A 1 91  ? 132.829 102.863 112.974 1.00 42.04  ? 91  THR A C   1 
ATOM   486  O O   . THR A 1 91  ? 132.231 102.851 114.056 1.00 42.04  ? 91  THR A O   1 
ATOM   487  C CB  . THR A 1 91  ? 131.832 104.148 111.066 1.00 42.04  ? 91  THR A CB  1 
ATOM   488  O OG1 . THR A 1 91  ? 131.991 105.304 110.236 1.00 42.04  ? 91  THR A OG1 1 
ATOM   489  C CG2 . THR A 1 91  ? 130.453 104.176 111.693 1.00 42.04  ? 91  THR A CG2 1 
ATOM   490  N N   . LEU A 1 92  ? 133.414 101.774 112.477 1.00 45.58  ? 92  LEU A N   1 
ATOM   491  C CA  . LEU A 1 92  ? 133.394 100.516 113.217 1.00 45.58  ? 92  LEU A CA  1 
ATOM   492  C C   . LEU A 1 92  ? 134.218 100.609 114.496 1.00 45.58  ? 92  LEU A C   1 
ATOM   493  O O   . LEU A 1 92  ? 133.856 100.014 115.516 1.00 45.58  ? 92  LEU A O   1 
ATOM   494  C CB  . LEU A 1 92  ? 133.896 99.380  112.331 1.00 45.58  ? 92  LEU A CB  1 
ATOM   495  C CG  . LEU A 1 92  ? 132.976 99.035  111.163 1.00 45.58  ? 92  LEU A CG  1 
ATOM   496  C CD1 . LEU A 1 92  ? 133.735 98.302  110.073 1.00 45.58  ? 92  LEU A CD1 1 
ATOM   497  C CD2 . LEU A 1 92  ? 131.808 98.202  111.656 1.00 45.58  ? 92  LEU A CD2 1 
ATOM   498  N N   . LEU A 1 93  ? 135.335 101.339 114.460 1.00 44.45  ? 93  LEU A N   1 
ATOM   499  C CA  . LEU A 1 93  ? 136.097 101.572 115.685 1.00 44.45  ? 93  LEU A CA  1 
ATOM   500  C C   . LEU A 1 93  ? 135.278 102.368 116.696 1.00 44.45  ? 93  LEU A C   1 
ATOM   501  O O   . LEU A 1 93  ? 135.293 102.073 117.900 1.00 44.45  ? 93  LEU A O   1 
ATOM   502  C CB  . LEU A 1 93  ? 137.405 102.290 115.360 1.00 44.45  ? 93  LEU A CB  1 
ATOM   503  C CG  . LEU A 1 93  ? 138.394 101.498 114.504 1.00 44.45  ? 93  LEU A CG  1 
ATOM   504  C CD1 . LEU A 1 93  ? 139.694 102.267 114.335 1.00 44.45  ? 93  LEU A CD1 1 
ATOM   505  C CD2 . LEU A 1 93  ? 138.653 100.129 115.109 1.00 44.45  ? 93  LEU A CD2 1 
ATOM   506  N N   . GLY A 1 94  ? 134.550 103.379 116.221 1.00 43.41  ? 94  GLY A N   1 
ATOM   507  C CA  . GLY A 1 94  ? 133.650 104.100 117.108 1.00 43.41  ? 94  GLY A CA  1 
ATOM   508  C C   . GLY A 1 94  ? 132.583 103.200 117.702 1.00 43.41  ? 94  GLY A C   1 
ATOM   509  O O   . GLY A 1 94  ? 132.246 103.308 118.886 1.00 43.41  ? 94  GLY A O   1 
ATOM   510  N N   . SER A 1 95  ? 132.039 102.297 116.886 1.00 45.30  ? 95  SER A N   1 
ATOM   511  C CA  . SER A 1 95  ? 131.039 101.357 117.379 1.00 45.30  ? 95  SER A CA  1 
ATOM   512  C C   . SER A 1 95  ? 131.631 100.424 118.427 1.00 45.30  ? 95  SER A C   1 
ATOM   513  O O   . SER A 1 95  ? 130.971 100.091 119.419 1.00 45.30  ? 95  SER A O   1 
ATOM   514  C CB  . SER A 1 95  ? 130.450 100.560 116.217 1.00 45.30  ? 95  SER A CB  1 
ATOM   515  O OG  . SER A 1 95  ? 129.488 101.328 115.517 1.00 45.30  ? 95  SER A OG  1 
ATOM   516  N N   . CYS A 1 96  ? 132.875 99.991  118.222 1.00 45.53  ? 96  CYS A N   1 
ATOM   517  C CA  . CYS A 1 96  ? 133.541 99.153  119.213 1.00 45.53  ? 96  CYS A CA  1 
ATOM   518  C C   . CYS A 1 96  ? 133.713 99.897  120.530 1.00 45.53  ? 96  CYS A C   1 
ATOM   519  O O   . CYS A 1 96  ? 133.518 99.323  121.608 1.00 45.53  ? 96  CYS A O   1 
ATOM   520  C CB  . CYS A 1 96  ? 134.893 98.682  118.681 1.00 45.53  ? 96  CYS A CB  1 
ATOM   521  S SG  . CYS A 1 96  ? 134.815 97.184  117.670 1.00 45.53  ? 96  CYS A SG  1 
ATOM   522  N N   . LEU A 1 97  ? 134.077 101.180 120.462 1.00 45.17  ? 97  LEU A N   1 
ATOM   523  C CA  . LEU A 1 97  ? 134.167 101.979 121.683 1.00 45.17  ? 97  LEU A CA  1 
ATOM   524  C C   . LEU A 1 97  ? 132.814 102.092 122.377 1.00 45.17  ? 97  LEU A C   1 
ATOM   525  O O   . LEU A 1 97  ? 132.730 102.017 123.610 1.00 45.17  ? 97  LEU A O   1 
ATOM   526  C CB  . LEU A 1 97  ? 134.722 103.365 121.369 1.00 45.17  ? 97  LEU A CB  1 
ATOM   527  C CG  . LEU A 1 97  ? 136.241 103.437 121.281 1.00 45.17  ? 97  LEU A CG  1 
ATOM   528  C CD1 . LEU A 1 97  ? 136.682 104.795 120.776 1.00 45.17  ? 97  LEU A CD1 1 
ATOM   529  C CD2 . LEU A 1 97  ? 136.858 103.142 122.636 1.00 45.17  ? 97  LEU A CD2 1 
ATOM   530  N N   . THR A 1 98  ? 131.743 102.278 121.604 1.00 45.58  ? 98  THR A N   1 
ATOM   531  C CA  . THR A 1 98  ? 130.423 102.408 122.215 1.00 45.58  ? 98  THR A CA  1 
ATOM   532  C C   . THR A 1 98  ? 129.989 101.112 122.890 1.00 45.58  ? 98  THR A C   1 
ATOM   533  O O   . THR A 1 98  ? 129.425 101.139 123.990 1.00 45.58  ? 98  THR A O   1 
ATOM   534  C CB  . THR A 1 98  ? 129.394 102.836 121.176 1.00 45.58  ? 98  THR A CB  1 
ATOM   535  O OG1 . THR A 1 98  ? 129.568 102.060 119.989 1.00 45.58  ? 98  THR A OG1 1 
ATOM   536  C CG2 . THR A 1 98  ? 129.555 104.307 120.845 1.00 45.58  ? 98  THR A CG2 1 
ATOM   537  N N   . TYR A 1 99  ? 130.237 99.964  122.253 1.00 45.24  ? 99  TYR A N   1 
ATOM   538  C CA  . TYR A 1 99  ? 129.928 98.694  122.910 1.00 45.24  ? 99  TYR A CA  1 
ATOM   539  C C   . TYR A 1 99  ? 130.816 98.438  124.123 1.00 45.24  ? 99  TYR A C   1 
ATOM   540  O O   . TYR A 1 99  ? 130.368 97.813  125.091 1.00 45.24  ? 99  TYR A O   1 
ATOM   541  C CB  . TYR A 1 99  ? 130.024 97.532  121.924 1.00 45.24  ? 99  TYR A CB  1 
ATOM   542  C CG  . TYR A 1 99  ? 128.973 97.549  120.841 1.00 45.24  ? 99  TYR A CG  1 
ATOM   543  C CD1 . TYR A 1 99  ? 127.628 97.476  121.162 1.00 45.24  ? 99  TYR A CD1 1 
ATOM   544  C CD2 . TYR A 1 99  ? 129.321 97.610  119.503 1.00 45.24  ? 99  TYR A CD2 1 
ATOM   545  C CE1 . TYR A 1 99  ? 126.662 97.476  120.185 1.00 45.24  ? 99  TYR A CE1 1 
ATOM   546  C CE2 . TYR A 1 99  ? 128.360 97.616  118.519 1.00 45.24  ? 99  TYR A CE2 1 
ATOM   547  C CZ  . TYR A 1 99  ? 127.033 97.548  118.864 1.00 45.24  ? 99  TYR A CZ  1 
ATOM   548  O OH  . TYR A 1 99  ? 126.071 97.553  117.882 1.00 45.24  ? 99  TYR A OH  1 
ATOM   549  N N   . SER A 1 100 ? 132.067 98.903  124.100 1.00 46.72  ? 100 SER A N   1 
ATOM   550  C CA  . SER A 1 100 ? 132.896 98.814  125.299 1.00 46.72  ? 100 SER A CA  1 
ATOM   551  C C   . SER A 1 100 ? 132.292 99.624  126.438 1.00 46.72  ? 100 SER A C   1 
ATOM   552  O O   . SER A 1 100 ? 132.250 99.168  127.589 1.00 46.72  ? 100 SER A O   1 
ATOM   553  C CB  . SER A 1 100 ? 134.314 99.291  124.991 1.00 46.72  ? 100 SER A CB  1 
ATOM   554  O OG  . SER A 1 100 ? 134.937 98.449  124.037 1.00 46.72  ? 100 SER A OG  1 
ATOM   555  N N   . SER A 1 101 ? 131.812 100.830 126.132 1.00 47.49  ? 101 SER A N   1 
ATOM   556  C CA  . SER A 1 101 ? 131.125 101.630 127.140 1.00 47.49  ? 101 SER A CA  1 
ATOM   557  C C   . SER A 1 101 ? 129.867 100.928 127.637 1.00 47.49  ? 101 SER A C   1 
ATOM   558  O O   . SER A 1 101 ? 129.537 100.991 128.828 1.00 47.49  ? 101 SER A O   1 
ATOM   559  C CB  . SER A 1 101 ? 130.781 103.004 126.570 1.00 47.49  ? 101 SER A CB  1 
ATOM   560  O OG  . SER A 1 101 ? 130.227 103.841 127.570 1.00 47.49  ? 101 SER A OG  1 
ATOM   561  N N   . ALA A 1 102 ? 129.147 100.259 126.735 1.00 48.13  ? 102 ALA A N   1 
ATOM   562  C CA  . ALA A 1 102 ? 127.963 99.508  127.139 1.00 48.13  ? 102 ALA A CA  1 
ATOM   563  C C   . ALA A 1 102 ? 128.322 98.385  128.104 1.00 48.13  ? 102 ALA A C   1 
ATOM   564  O O   . ALA A 1 102 ? 127.612 98.153  129.089 1.00 48.13  ? 102 ALA A O   1 
ATOM   565  C CB  . ALA A 1 102 ? 127.250 98.954  125.908 1.00 48.13  ? 102 ALA A CB  1 
ATOM   566  N N   . TYR A 1 103 ? 129.418 97.671  127.831 1.00 49.75  ? 103 TYR A N   1 
ATOM   567  C CA  . TYR A 1 103 ? 129.919 96.678  128.780 1.00 49.75  ? 103 TYR A CA  1 
ATOM   568  C C   . TYR A 1 103 ? 130.214 97.306  130.134 1.00 49.75  ? 103 TYR A C   1 
ATOM   569  O O   . TYR A 1 103 ? 129.773 96.804  131.173 1.00 49.75  ? 103 TYR A O   1 
ATOM   570  C CB  . TYR A 1 103 ? 131.177 96.000  128.235 1.00 49.75  ? 103 TYR A CB  1 
ATOM   571  C CG  . TYR A 1 103 ? 130.930 94.965  127.170 1.00 49.75  ? 103 TYR A CG  1 
ATOM   572  C CD1 . TYR A 1 103 ? 129.677 94.405  126.996 1.00 49.75  ? 103 TYR A CD1 1 
ATOM   573  C CD2 . TYR A 1 103 ? 131.955 94.546  126.336 1.00 49.75  ? 103 TYR A CD2 1 
ATOM   574  C CE1 . TYR A 1 103 ? 129.453 93.453  126.029 1.00 49.75  ? 103 TYR A CE1 1 
ATOM   575  C CE2 . TYR A 1 103 ? 131.737 93.598  125.362 1.00 49.75  ? 103 TYR A CE2 1 
ATOM   576  C CZ  . TYR A 1 103 ? 130.483 93.057  125.211 1.00 49.75  ? 103 TYR A CZ  1 
ATOM   577  O OH  . TYR A 1 103 ? 130.260 92.111  124.240 1.00 49.75  ? 103 TYR A OH  1 
ATOM   578  N N   . LEU A 1 104 ? 130.970 98.405  130.141 1.00 50.80  ? 104 LEU A N   1 
ATOM   579  C CA  . LEU A 1 104 ? 131.317 99.040  131.408 1.00 50.80  ? 104 LEU A CA  1 
ATOM   580  C C   . LEU A 1 104 ? 130.099 99.558  132.158 1.00 50.80  ? 104 LEU A C   1 
ATOM   581  O O   . LEU A 1 104 ? 130.157 99.704  133.384 1.00 50.80  ? 104 LEU A O   1 
ATOM   582  C CB  . LEU A 1 104 ? 132.309 100.184 131.187 1.00 50.80  ? 104 LEU A CB  1 
ATOM   583  C CG  . LEU A 1 104 ? 133.790 99.804  131.255 1.00 50.80  ? 104 LEU A CG  1 
ATOM   584  C CD1 . LEU A 1 104 ? 134.249 99.070  130.007 1.00 50.80  ? 104 LEU A CD1 1 
ATOM   585  C CD2 . LEU A 1 104 ? 134.655 101.019 131.536 1.00 50.80  ? 104 LEU A CD2 1 
ATOM   586  N N   . PHE A 1 105 ? 129.004 99.848  131.455 1.00 50.09  ? 105 PHE A N   1 
ATOM   587  C CA  . PHE A 1 105 ? 127.763 100.212 132.134 1.00 50.09  ? 105 PHE A CA  1 
ATOM   588  C C   . PHE A 1 105 ? 127.267 99.110  133.059 1.00 50.09  ? 105 PHE A C   1 
ATOM   589  O O   . PHE A 1 105 ? 126.595 99.396  134.057 1.00 50.09  ? 105 PHE A O   1 
ATOM   590  C CB  . PHE A 1 105 ? 126.692 100.587 131.113 1.00 50.09  ? 105 PHE A CB  1 
ATOM   591  C CG  . PHE A 1 105 ? 126.617 102.059 130.848 1.00 50.09  ? 105 PHE A CG  1 
ATOM   592  C CD1 . PHE A 1 105 ? 126.313 102.940 131.868 1.00 50.09  ? 105 PHE A CD1 1 
ATOM   593  C CD2 . PHE A 1 105 ? 126.877 102.566 129.591 1.00 50.09  ? 105 PHE A CD2 1 
ATOM   594  C CE1 . PHE A 1 105 ? 126.255 104.293 131.634 1.00 50.09  ? 105 PHE A CE1 1 
ATOM   595  C CE2 . PHE A 1 105 ? 126.819 103.919 129.356 1.00 50.09  ? 105 PHE A CE2 1 
ATOM   596  C CZ  . PHE A 1 105 ? 126.507 104.782 130.378 1.00 50.09  ? 105 PHE A CZ  1 
ATOM   597  N N   . GLY A 1 106 ? 127.578 97.854  132.753 1.00 54.47  ? 106 GLY A N   1 
ATOM   598  C CA  . GLY A 1 106 ? 127.216 96.763  133.634 1.00 54.47  ? 106 GLY A CA  1 
ATOM   599  C C   . GLY A 1 106 ? 128.276 96.441  134.662 1.00 54.47  ? 106 GLY A C   1 
ATOM   600  O O   . GLY A 1 106 ? 128.545 95.271  134.951 1.00 54.47  ? 106 GLY A O   1 
ATOM   601  N N   . ILE A 1 107 ? 128.885 97.481  135.222 1.00 59.57  ? 107 ILE A N   1 
ATOM   602  C CA  . ILE A 1 107 ? 129.845 97.348  136.316 1.00 59.57  ? 107 ILE A CA  1 
ATOM   603  C C   . ILE A 1 107 ? 129.367 98.309  137.400 1.00 59.57  ? 107 ILE A C   1 
ATOM   604  O O   . ILE A 1 107 ? 129.698 99.499  137.388 1.00 59.57  ? 107 ILE A O   1 
ATOM   605  C CB  . ILE A 1 107 ? 131.282 97.658  135.884 1.00 59.57  ? 107 ILE A CB  1 
ATOM   606  C CG1 . ILE A 1 107 ? 131.747 96.658  134.826 1.00 59.57  ? 107 ILE A CG1 1 
ATOM   607  C CG2 . ILE A 1 107 ? 132.221 97.607  137.074 1.00 59.57  ? 107 ILE A CG2 1 
ATOM   608  C CD1 . ILE A 1 107 ? 133.049 97.039  134.159 1.00 59.57  ? 107 ILE A CD1 1 
ATOM   609  N N   . GLN A 1 108 ? 128.562 97.806  138.331 1.00 69.94  ? 108 GLN A N   1 
ATOM   610  C CA  . GLN A 1 108 ? 127.984 98.632  139.383 1.00 69.94  ? 108 GLN A CA  1 
ATOM   611  C C   . GLN A 1 108 ? 128.150 97.944  140.727 1.00 69.94  ? 108 GLN A C   1 
ATOM   612  O O   . GLN A 1 108 ? 127.733 96.793  140.895 1.00 69.94  ? 108 GLN A O   1 
ATOM   613  C CB  . GLN A 1 108 ? 126.499 98.911  139.120 1.00 69.94  ? 108 GLN A CB  1 
ATOM   614  C CG  . GLN A 1 108 ? 126.195 99.478  137.742 1.00 69.94  ? 108 GLN A CG  1 
ATOM   615  C CD  . GLN A 1 108 ? 124.708 99.562  137.462 1.00 69.94  ? 108 GLN A CD  1 
ATOM   616  O OE1 . GLN A 1 108 ? 123.884 99.233  138.316 1.00 69.94  ? 108 GLN A OE1 1 
ATOM   617  N NE2 . GLN A 1 108 ? 124.356 100.003 136.260 1.00 69.94  ? 108 GLN A NE2 1 
ATOM   618  N N   . ASP A 1 109 ? 128.776 98.647  141.673 1.00 79.84  ? 109 ASP A N   1 
ATOM   619  C CA  . ASP A 1 109 ? 128.853 98.235  143.072 1.00 79.84  ? 109 ASP A CA  1 
ATOM   620  C C   . ASP A 1 109 ? 129.630 96.937  143.274 1.00 79.84  ? 109 ASP A C   1 
ATOM   621  O O   . ASP A 1 109 ? 129.742 96.452  144.404 1.00 79.84  ? 109 ASP A O   1 
ATOM   622  C CB  . ASP A 1 109 ? 127.447 98.099  143.664 1.00 79.84  ? 109 ASP A CB  1 
ATOM   623  C CG  . ASP A 1 109 ? 126.566 99.294  143.354 1.00 79.84  ? 109 ASP A CG  1 
ATOM   624  O OD1 . ASP A 1 109 ? 127.100 100.419 143.258 1.00 79.84  ? 109 ASP A OD1 1 
ATOM   625  O OD2 . ASP A 1 109 ? 125.340 99.108  143.206 1.00 79.84  ? 109 ASP A OD2 1 
ATOM   626  N N   . VAL A 1 110 ? 130.165 96.363  142.194 1.00 82.64  ? 110 VAL A N   1 
ATOM   627  C CA  . VAL A 1 110 ? 130.999 95.173  142.334 1.00 82.64  ? 110 VAL A CA  1 
ATOM   628  C C   . VAL A 1 110 ? 132.294 95.519  143.057 1.00 82.64  ? 110 VAL A C   1 
ATOM   629  O O   . VAL A 1 110 ? 132.823 94.717  143.836 1.00 82.64  ? 110 VAL A O   1 
ATOM   630  C CB  . VAL A 1 110 ? 131.257 94.533  140.956 1.00 82.64  ? 110 VAL A CB  1 
ATOM   631  C CG1 . VAL A 1 110 ? 131.897 95.532  140.006 1.00 82.64  ? 110 VAL A CG1 1 
ATOM   632  C CG2 . VAL A 1 110 ? 132.119 93.285  141.094 1.00 82.64  ? 110 VAL A CG2 1 
ATOM   633  N N   . LEU A 1 111 ? 132.816 96.720  142.824 1.00 82.93  ? 111 LEU A N   1 
ATOM   634  C CA  . LEU A 1 111 ? 134.014 97.213  143.484 1.00 82.93  ? 111 LEU A CA  1 
ATOM   635  C C   . LEU A 1 111 ? 133.640 98.298  144.484 1.00 82.93  ? 111 LEU A C   1 
ATOM   636  O O   . LEU A 1 111 ? 132.754 99.119  144.224 1.00 82.93  ? 111 LEU A O   1 
ATOM   637  C CB  . LEU A 1 111 ? 135.021 97.746  142.457 1.00 82.93  ? 111 LEU A CB  1 
ATOM   638  C CG  . LEU A 1 111 ? 134.574 98.840  141.479 1.00 82.93  ? 111 LEU A CG  1 
ATOM   639  C CD1 . LEU A 1 111 ? 134.773 100.240 142.046 1.00 82.93  ? 111 LEU A CD1 1 
ATOM   640  C CD2 . LEU A 1 111 ? 135.298 98.691  140.149 1.00 82.93  ? 111 LEU A CD2 1 
ATOM   641  N N   . VAL A 1 112 ? 134.306 98.285  145.641 1.00 85.22  ? 112 VAL A N   1 
ATOM   642  C CA  . VAL A 1 112 ? 134.069 99.279  146.680 1.00 85.22  ? 112 VAL A CA  1 
ATOM   643  C C   . VAL A 1 112 ? 135.125 100.373 146.688 1.00 85.22  ? 112 VAL A C   1 
ATOM   644  O O   . VAL A 1 112 ? 135.040 101.299 147.506 1.00 85.22  ? 112 VAL A O   1 
ATOM   645  C CB  . VAL A 1 112 ? 133.984 98.616  148.070 1.00 85.22  ? 112 VAL A CB  1 
ATOM   646  C CG1 . VAL A 1 112 ? 132.878 97.573  148.092 1.00 85.22  ? 112 VAL A CG1 1 
ATOM   647  C CG2 . VAL A 1 112 ? 135.321 97.995  148.443 1.00 85.22  ? 112 VAL A CG2 1 
ATOM   648  N N   . GLY A 1 113 ? 136.117 100.297 145.804 1.00 81.97  ? 113 GLY A N   1 
ATOM   649  C CA  . GLY A 1 113 ? 137.182 101.273 145.771 1.00 81.97  ? 113 GLY A CA  1 
ATOM   650  C C   . GLY A 1 113 ? 136.795 102.549 145.048 1.00 81.97  ? 113 GLY A C   1 
ATOM   651  O O   . GLY A 1 113 ? 135.680 102.719 144.554 1.00 81.97  ? 113 GLY A O   1 
ATOM   652  N N   . SER A 1 114 ? 137.759 103.469 144.991 1.00 76.99  ? 114 SER A N   1 
ATOM   653  C CA  . SER A 1 114 ? 137.556 104.740 144.307 1.00 76.99  ? 114 SER A CA  1 
ATOM   654  C C   . SER A 1 114 ? 137.390 104.572 142.804 1.00 76.99  ? 114 SER A C   1 
ATOM   655  O O   . SER A 1 114 ? 136.928 105.503 142.140 1.00 76.99  ? 114 SER A O   1 
ATOM   656  C CB  . SER A 1 114 ? 138.722 105.686 144.597 1.00 76.99  ? 114 SER A CB  1 
ATOM   657  O OG  . SER A 1 114 ? 139.942 105.156 144.107 1.00 76.99  ? 114 SER A OG  1 
ATOM   658  N N   . SER A 1 115 ? 137.773 103.417 142.260 1.00 71.56  ? 115 SER A N   1 
ATOM   659  C CA  . SER A 1 115 ? 137.617 103.080 140.848 1.00 71.56  ? 115 SER A CA  1 
ATOM   660  C C   . SER A 1 115 ? 136.294 103.541 140.241 1.00 71.56  ? 115 SER A C   1 
ATOM   661  O O   . SER A 1 115 ? 136.259 103.935 139.072 1.00 71.56  ? 115 SER A O   1 
ATOM   662  C CB  . SER A 1 115 ? 137.772 101.571 140.654 1.00 71.56  ? 115 SER A CB  1 
ATOM   663  O OG  . SER A 1 115 ? 138.901 101.081 141.356 1.00 71.56  ? 115 SER A OG  1 
ATOM   664  N N   . MET A 1 116 ? 135.202 103.469 141.005 1.00 67.58  ? 116 MET A N   1 
ATOM   665  C CA  . MET A 1 116 ? 133.918 104.022 140.579 1.00 67.58  ? 116 MET A CA  1 
ATOM   666  C C   . MET A 1 116 ? 134.044 105.415 139.968 1.00 67.58  ? 116 MET A C   1 
ATOM   667  O O   . MET A 1 116 ? 133.380 105.721 138.970 1.00 67.58  ? 116 MET A O   1 
ATOM   668  C CB  . MET A 1 116 ? 132.948 104.065 141.762 1.00 67.58  ? 116 MET A CB  1 
ATOM   669  C CG  . MET A 1 116 ? 131.488 104.160 141.364 1.00 67.58  ? 116 MET A CG  1 
ATOM   670  S SD  . MET A 1 116 ? 130.902 102.680 140.524 1.00 67.58  ? 116 MET A SD  1 
ATOM   671  C CE  . MET A 1 116 ? 131.206 101.441 141.780 1.00 67.58  ? 116 MET A CE  1 
ATOM   672  N N   . GLU A 1 117 ? 134.909 106.252 140.543 1.00 64.70  ? 117 GLU A N   1 
ATOM   673  C CA  . GLU A 1 117 ? 135.236 107.554 139.972 1.00 64.70  ? 117 GLU A CA  1 
ATOM   674  C C   . GLU A 1 117 ? 135.684 107.406 138.525 1.00 64.70  ? 117 GLU A C   1 
ATOM   675  O O   . GLU A 1 117 ? 134.996 107.854 137.598 1.00 64.70  ? 117 GLU A O   1 
ATOM   676  C CB  . GLU A 1 117 ? 136.333 108.240 140.790 1.00 64.70  ? 117 GLU A CB  1 
ATOM   677  C CG  . GLU A 1 117 ? 135.967 108.516 142.238 1.00 64.70  ? 117 GLU A CG  1 
ATOM   678  C CD  . GLU A 1 117 ? 135.408 109.903 142.442 1.00 64.70  ? 117 GLU A CD  1 
ATOM   679  O OE1 . GLU A 1 117 ? 135.914 110.848 141.801 1.00 64.70  ? 117 GLU A OE1 1 
ATOM   680  O OE2 . GLU A 1 117 ? 134.467 110.053 143.248 1.00 64.70  ? 117 GLU A OE2 1 
ATOM   681  N N   . THR A 1 118 ? 136.827 106.745 138.327 1.00 59.91  ? 118 THR A N   1 
ATOM   682  C CA  . THR A 1 118 ? 137.347 106.571 136.980 1.00 59.91  ? 118 THR A CA  1 
ATOM   683  C C   . THR A 1 118 ? 136.475 105.637 136.160 1.00 59.91  ? 118 THR A C   1 
ATOM   684  O O   . THR A 1 118 ? 136.493 105.723 134.932 1.00 59.91  ? 118 THR A O   1 
ATOM   685  C CB  . THR A 1 118 ? 138.791 106.059 137.014 1.00 59.91  ? 118 THR A CB  1 
ATOM   686  O OG1 . THR A 1 118 ? 139.329 106.061 135.686 1.00 59.91  ? 118 THR A OG1 1 
ATOM   687  C CG2 . THR A 1 118 ? 138.862 104.650 137.574 1.00 59.91  ? 118 THR A CG2 1 
ATOM   688  N N   . LEU A 1 119 ? 135.674 104.791 136.810 1.00 59.03  ? 119 LEU A N   1 
ATOM   689  C CA  . LEU A 1 119 ? 134.719 103.965 136.082 1.00 59.03  ? 119 LEU A CA  1 
ATOM   690  C C   . LEU A 1 119 ? 133.720 104.835 135.331 1.00 59.03  ? 119 LEU A C   1 
ATOM   691  O O   . LEU A 1 119 ? 133.589 104.739 134.104 1.00 59.03  ? 119 LEU A O   1 
ATOM   692  C CB  . LEU A 1 119 ? 133.999 103.026 137.048 1.00 59.03  ? 119 LEU A CB  1 
ATOM   693  C CG  . LEU A 1 119 ? 132.986 102.056 136.447 1.00 59.03  ? 119 LEU A CG  1 
ATOM   694  C CD1 . LEU A 1 119 ? 133.635 101.191 135.382 1.00 59.03  ? 119 LEU A CD1 1 
ATOM   695  C CD2 . LEU A 1 119 ? 132.386 101.202 137.544 1.00 59.03  ? 119 LEU A CD2 1 
ATOM   696  N N   . ILE A 1 120 ? 133.012 105.705 136.056 1.00 53.87  ? 120 ILE A N   1 
ATOM   697  C CA  . ILE A 1 120 ? 132.043 106.590 135.414 1.00 53.87  ? 120 ILE A CA  1 
ATOM   698  C C   . ILE A 1 120 ? 132.739 107.541 134.451 1.00 53.87  ? 120 ILE A C   1 
ATOM   699  O O   . ILE A 1 120 ? 132.234 107.811 133.350 1.00 53.87  ? 120 ILE A O   1 
ATOM   700  C CB  . ILE A 1 120 ? 131.227 107.353 136.472 1.00 53.87  ? 120 ILE A CB  1 
ATOM   701  C CG1 . ILE A 1 120 ? 130.632 106.377 137.482 1.00 53.87  ? 120 ILE A CG1 1 
ATOM   702  C CG2 . ILE A 1 120 ? 130.118 108.147 135.814 1.00 53.87  ? 120 ILE A CG2 1 
ATOM   703  C CD1 . ILE A 1 120 ? 130.038 107.045 138.680 1.00 53.87  ? 120 ILE A CD1 1 
ATOM   704  N N   . GLN A 1 121 ? 133.898 108.079 134.847 1.00 53.63  ? 121 GLN A N   1 
ATOM   705  C CA  . GLN A 1 121 ? 134.609 109.002 133.968 1.00 53.63  ? 121 GLN A CA  1 
ATOM   706  C C   . GLN A 1 121 ? 134.929 108.346 132.632 1.00 53.63  ? 121 GLN A C   1 
ATOM   707  O O   . GLN A 1 121 ? 134.627 108.900 131.569 1.00 53.63  ? 121 GLN A O   1 
ATOM   708  C CB  . GLN A 1 121 ? 135.882 109.515 134.639 1.00 53.63  ? 121 GLN A CB  1 
ATOM   709  C CG  . GLN A 1 121 ? 135.640 110.397 135.847 1.00 53.63  ? 121 GLN A CG  1 
ATOM   710  C CD  . GLN A 1 121 ? 136.929 110.866 136.489 1.00 53.63  ? 121 GLN A CD  1 
ATOM   711  O OE1 . GLN A 1 121 ? 138.020 110.480 136.072 1.00 53.63  ? 121 GLN A OE1 1 
ATOM   712  N NE2 . GLN A 1 121 ? 136.810 111.706 137.511 1.00 53.63  ? 121 GLN A NE2 1 
ATOM   713  N N   . THR A 1 122 ? 135.541 107.160 132.666 1.00 51.68  ? 122 THR A N   1 
ATOM   714  C CA  . THR A 1 122 ? 135.917 106.474 131.440 1.00 51.68  ? 122 THR A CA  1 
ATOM   715  C C   . THR A 1 122 ? 134.695 106.034 130.652 1.00 51.68  ? 122 THR A C   1 
ATOM   716  O O   . THR A 1 122 ? 134.718 106.058 129.418 1.00 51.68  ? 122 THR A O   1 
ATOM   717  C CB  . THR A 1 122 ? 136.794 105.271 131.772 1.00 51.68  ? 122 THR A CB  1 
ATOM   718  O OG1 . THR A 1 122 ? 137.813 105.668 132.696 1.00 51.68  ? 122 THR A OG1 1 
ATOM   719  C CG2 . THR A 1 122 ? 137.453 104.729 130.516 1.00 51.68  ? 122 THR A CG2 1 
ATOM   720  N N   . ARG A 1 123 ? 133.612 105.664 131.338 1.00 48.96  ? 123 ARG A N   1 
ATOM   721  C CA  . ARG A 1 123 ? 132.406 105.241 130.638 1.00 48.96  ? 123 ARG A CA  1 
ATOM   722  C C   . ARG A 1 123 ? 131.823 106.382 129.817 1.00 48.96  ? 123 ARG A C   1 
ATOM   723  O O   . ARG A 1 123 ? 131.533 106.226 128.622 1.00 48.96  ? 123 ARG A O   1 
ATOM   724  C CB  . ARG A 1 123 ? 131.387 104.748 131.661 1.00 48.96  ? 123 ARG A CB  1 
ATOM   725  C CG  . ARG A 1 123 ? 130.588 103.546 131.256 1.00 48.96  ? 123 ARG A CG  1 
ATOM   726  C CD  . ARG A 1 123 ? 129.889 102.984 132.476 1.00 48.96  ? 123 ARG A CD  1 
ATOM   727  N NE  . ARG A 1 123 ? 129.115 104.001 133.176 1.00 48.96  ? 123 ARG A NE  1 
ATOM   728  C CZ  . ARG A 1 123 ? 128.840 103.973 134.472 1.00 48.96  ? 123 ARG A CZ  1 
ATOM   729  N NH1 . ARG A 1 123 ? 129.270 102.994 135.249 1.00 48.96  ? 123 ARG A NH1 1 
ATOM   730  N NH2 . ARG A 1 123 ? 128.112 104.951 135.002 1.00 48.96  ? 123 ARG A NH2 1 
ATOM   731  N N   . LEU A 1 124 ? 131.669 107.554 130.438 1.00 47.84  ? 124 LEU A N   1 
ATOM   732  C CA  . LEU A 1 124 ? 131.158 108.708 129.706 1.00 47.84  ? 124 LEU A CA  1 
ATOM   733  C C   . LEU A 1 124 ? 132.147 109.182 128.646 1.00 47.84  ? 124 LEU A C   1 
ATOM   734  O O   . LEU A 1 124 ? 131.740 109.605 127.553 1.00 47.84  ? 124 LEU A O   1 
ATOM   735  C CB  . LEU A 1 124 ? 130.819 109.833 130.682 1.00 47.84  ? 124 LEU A CB  1 
ATOM   736  C CG  . LEU A 1 124 ? 129.800 109.454 131.757 1.00 47.84  ? 124 LEU A CG  1 
ATOM   737  C CD1 . LEU A 1 124 ? 129.487 110.635 132.654 1.00 47.84  ? 124 LEU A CD1 1 
ATOM   738  C CD2 . LEU A 1 124 ? 128.537 108.913 131.122 1.00 47.84  ? 124 LEU A CD2 1 
ATOM   739  N N   . SER A 1 125 ? 133.451 109.094 128.935 1.00 46.98  ? 125 SER A N   1 
ATOM   740  C CA  . SER A 1 125 ? 134.448 109.498 127.951 1.00 46.98  ? 125 SER A CA  1 
ATOM   741  C C   . SER A 1 125 ? 134.368 108.621 126.715 1.00 46.98  ? 125 SER A C   1 
ATOM   742  O O   . SER A 1 125 ? 134.491 109.110 125.587 1.00 46.98  ? 125 SER A O   1 
ATOM   743  C CB  . SER A 1 125 ? 135.843 109.443 128.567 1.00 46.98  ? 125 SER A CB  1 
ATOM   744  O OG  . SER A 1 125 ? 135.863 110.096 129.824 1.00 46.98  ? 125 SER A OG  1 
ATOM   745  N N   . MET A 1 126 ? 134.098 107.329 126.901 1.00 46.71  ? 126 MET A N   1 
ATOM   746  C CA  . MET A 1 126 ? 134.081 106.445 125.751 1.00 46.71  ? 126 MET A CA  1 
ATOM   747  C C   . MET A 1 126 ? 132.765 106.580 125.012 1.00 46.71  ? 126 MET A C   1 
ATOM   748  O O   . MET A 1 126 ? 132.738 106.440 123.791 1.00 46.71  ? 126 MET A O   1 
ATOM   749  C CB  . MET A 1 126 ? 134.334 104.997 126.157 1.00 46.71  ? 126 MET A CB  1 
ATOM   750  C CG  . MET A 1 126 ? 135.721 104.742 126.692 1.00 46.71  ? 126 MET A CG  1 
ATOM   751  S SD  . MET A 1 126 ? 135.950 103.004 127.080 1.00 46.71  ? 126 MET A SD  1 
ATOM   752  C CE  . MET A 1 126 ? 134.978 102.882 128.573 1.00 46.71  ? 126 MET A CE  1 
ATOM   753  N N   . LEU A 1 127 ? 131.675 106.866 125.727 1.00 47.05  ? 127 LEU A N   1 
ATOM   754  C CA  . LEU A 1 127 ? 130.434 107.214 125.044 1.00 47.05  ? 127 LEU A CA  1 
ATOM   755  C C   . LEU A 1 127 ? 130.653 108.392 124.104 1.00 47.05  ? 127 LEU A C   1 
ATOM   756  O O   . LEU A 1 127 ? 130.286 108.338 122.924 1.00 47.05  ? 127 LEU A O   1 
ATOM   757  C CB  . LEU A 1 127 ? 129.337 107.542 126.053 1.00 47.05  ? 127 LEU A CB  1 
ATOM   758  C CG  . LEU A 1 127 ? 128.485 106.391 126.567 1.00 47.05  ? 127 LEU A CG  1 
ATOM   759  C CD1 . LEU A 1 127 ? 127.615 106.877 127.702 1.00 47.05  ? 127 LEU A CD1 1 
ATOM   760  C CD2 . LEU A 1 127 ? 127.640 105.848 125.437 1.00 47.05  ? 127 LEU A CD2 1 
ATOM   761  N N   . CYS A 1 128 ? 131.251 109.470 124.617 1.00 47.02  ? 128 CYS A N   1 
ATOM   762  C CA  . CYS A 1 128 ? 131.456 110.663 123.798 1.00 47.02  ? 128 CYS A CA  1 
ATOM   763  C C   . CYS A 1 128 ? 132.387 110.379 122.624 1.00 47.02  ? 128 CYS A C   1 
ATOM   764  O O   . CYS A 1 128 ? 132.096 110.754 121.479 1.00 47.02  ? 128 CYS A O   1 
ATOM   765  C CB  . CYS A 1 128 ? 132.011 111.797 124.657 1.00 47.02  ? 128 CYS A CB  1 
ATOM   766  S SG  . CYS A 1 128 ? 132.476 113.276 123.728 1.00 47.02  ? 128 CYS A SG  1 
ATOM   767  N N   . ILE A 1 129 ? 133.513 109.709 122.888 1.00 43.71  ? 129 ILE A N   1 
ATOM   768  C CA  . ILE A 1 129 ? 134.476 109.428 121.827 1.00 43.71  ? 129 ILE A CA  1 
ATOM   769  C C   . ILE A 1 129 ? 133.858 108.522 120.769 1.00 43.71  ? 129 ILE A C   1 
ATOM   770  O O   . ILE A 1 129 ? 134.044 108.736 119.566 1.00 43.71  ? 129 ILE A O   1 
ATOM   771  C CB  . ILE A 1 129 ? 135.764 108.826 122.414 1.00 43.71  ? 129 ILE A CB  1 
ATOM   772  C CG1 . ILE A 1 129 ? 136.476 109.851 123.293 1.00 43.71  ? 129 ILE A CG1 1 
ATOM   773  C CG2 . ILE A 1 129 ? 136.696 108.377 121.308 1.00 43.71  ? 129 ILE A CG2 1 
ATOM   774  C CD1 . ILE A 1 129 ? 136.711 111.177 122.615 1.00 43.71  ? 129 ILE A CD1 1 
ATOM   775  N N   . GLY A 1 130 ? 133.109 107.503 121.194 1.00 42.26  ? 130 GLY A N   1 
ATOM   776  C CA  . GLY A 1 130 ? 132.482 106.606 120.241 1.00 42.26  ? 130 GLY A CA  1 
ATOM   777  C C   . GLY A 1 130 ? 131.414 107.279 119.405 1.00 42.26  ? 130 GLY A C   1 
ATOM   778  O O   . GLY A 1 130 ? 131.320 107.037 118.201 1.00 42.26  ? 130 GLY A O   1 
ATOM   779  N N   . THR A 1 131 ? 130.592 108.129 120.024 1.00 43.08  ? 131 THR A N   1 
ATOM   780  C CA  . THR A 1 131 ? 129.588 108.855 119.252 1.00 43.08  ? 131 THR A CA  1 
ATOM   781  C C   . THR A 1 131 ? 130.244 109.765 118.226 1.00 43.08  ? 131 THR A C   1 
ATOM   782  O O   . THR A 1 131 ? 129.815 109.819 117.065 1.00 43.08  ? 131 THR A O   1 
ATOM   783  C CB  . THR A 1 131 ? 128.685 109.661 120.182 1.00 43.08  ? 131 THR A CB  1 
ATOM   784  O OG1 . THR A 1 131 ? 128.022 108.775 121.091 1.00 43.08  ? 131 THR A OG1 1 
ATOM   785  C CG2 . THR A 1 131 ? 127.647 110.426 119.382 1.00 43.08  ? 131 THR A CG2 1 
ATOM   786  N N   . SER A 1 132 ? 131.298 110.477 118.633 1.00 42.18  ? 132 SER A N   1 
ATOM   787  C CA  . SER A 1 132 ? 132.012 111.340 117.699 1.00 42.18  ? 132 SER A CA  1 
ATOM   788  C C   . SER A 1 132 ? 132.612 110.529 116.557 1.00 42.18  ? 132 SER A C   1 
ATOM   789  O O   . SER A 1 132 ? 132.484 110.897 115.383 1.00 42.18  ? 132 SER A O   1 
ATOM   790  C CB  . SER A 1 132 ? 133.099 112.112 118.443 1.00 42.18  ? 132 SER A CB  1 
ATOM   791  O OG  . SER A 1 132 ? 132.566 112.782 119.571 1.00 42.18  ? 132 SER A OG  1 
ATOM   792  N N   . LEU A 1 133 ? 133.251 109.405 116.885 1.00 40.85  ? 133 LEU A N   1 
ATOM   793  C CA  . LEU A 1 133 ? 133.918 108.588 115.883 1.00 40.85  ? 133 LEU A CA  1 
ATOM   794  C C   . LEU A 1 133 ? 132.936 107.864 114.975 1.00 40.85  ? 133 LEU A C   1 
ATOM   795  O O   . LEU A 1 133 ? 133.317 107.457 113.873 1.00 40.85  ? 133 LEU A O   1 
ATOM   796  C CB  . LEU A 1 133 ? 134.829 107.571 116.568 1.00 40.85  ? 133 LEU A CB  1 
ATOM   797  C CG  . LEU A 1 133 ? 136.275 107.976 116.841 1.00 40.85  ? 133 LEU A CG  1 
ATOM   798  C CD1 . LEU A 1 133 ? 136.907 107.038 117.847 1.00 40.85  ? 133 LEU A CD1 1 
ATOM   799  C CD2 . LEU A 1 133 ? 137.066 107.971 115.561 1.00 40.85  ? 133 LEU A CD2 1 
ATOM   800  N N   . VAL A 1 134 ? 131.695 107.668 115.418 1.00 41.74  ? 134 VAL A N   1 
ATOM   801  C CA  . VAL A 1 134 ? 130.691 107.053 114.559 1.00 41.74  ? 134 VAL A CA  1 
ATOM   802  C C   . VAL A 1 134 ? 130.052 108.087 113.644 1.00 41.74  ? 134 VAL A C   1 
ATOM   803  O O   . VAL A 1 134 ? 129.833 107.828 112.456 1.00 41.74  ? 134 VAL A O   1 
ATOM   804  C CB  . VAL A 1 134 ? 129.642 106.317 115.411 1.00 41.74  ? 134 VAL A CB  1 
ATOM   805  C CG1 . VAL A 1 134 ? 128.400 106.023 114.597 1.00 41.74  ? 134 VAL A CG1 1 
ATOM   806  C CG2 . VAL A 1 134 ? 130.223 105.027 115.958 1.00 41.74  ? 134 VAL A CG2 1 
ATOM   807  N N   . PHE A 1 135 ? 129.759 109.279 114.164 1.00 41.02  ? 135 PHE A N   1 
ATOM   808  C CA  . PHE A 1 135 ? 128.980 110.235 113.391 1.00 41.02  ? 135 PHE A CA  1 
ATOM   809  C C   . PHE A 1 135 ? 129.818 111.167 112.528 1.00 41.02  ? 135 PHE A C   1 
ATOM   810  O O   . PHE A 1 135 ? 129.303 111.672 111.525 1.00 41.02  ? 135 PHE A O   1 
ATOM   811  C CB  . PHE A 1 135 ? 128.077 111.058 114.312 1.00 41.02  ? 135 PHE A CB  1 
ATOM   812  C CG  . PHE A 1 135 ? 126.696 110.493 114.447 1.00 41.02  ? 135 PHE A CG  1 
ATOM   813  C CD1 . PHE A 1 135 ? 125.761 110.680 113.445 1.00 41.02  ? 135 PHE A CD1 1 
ATOM   814  C CD2 . PHE A 1 135 ? 126.338 109.757 115.560 1.00 41.02  ? 135 PHE A CD2 1 
ATOM   815  C CE1 . PHE A 1 135 ? 124.492 110.155 113.555 1.00 41.02  ? 135 PHE A CE1 1 
ATOM   816  C CE2 . PHE A 1 135 ? 125.069 109.229 115.677 1.00 41.02  ? 135 PHE A CE2 1 
ATOM   817  C CZ  . PHE A 1 135 ? 124.144 109.430 114.673 1.00 41.02  ? 135 PHE A CZ  1 
ATOM   818  N N   . GLY A 1 136 ? 131.080 111.411 112.869 1.00 39.83  ? 136 GLY A N   1 
ATOM   819  C CA  . GLY A 1 136 ? 131.919 112.259 112.058 1.00 39.83  ? 136 GLY A CA  1 
ATOM   820  C C   . GLY A 1 136 ? 132.163 111.735 110.655 1.00 39.83  ? 136 GLY A C   1 
ATOM   821  O O   . GLY A 1 136 ? 132.024 112.469 109.671 1.00 39.83  ? 136 GLY A O   1 
ATOM   822  N N   . PRO A 1 137 ? 132.562 110.462 110.532 1.00 39.65  ? 137 PRO A N   1 
ATOM   823  C CA  . PRO A 1 137 ? 132.850 109.922 109.192 1.00 39.65  ? 137 PRO A CA  1 
ATOM   824  C C   . PRO A 1 137 ? 131.670 109.954 108.238 1.00 39.65  ? 137 PRO A C   1 
ATOM   825  O O   . PRO A 1 137 ? 131.862 110.198 107.040 1.00 39.65  ? 137 PRO A O   1 
ATOM   826  C CB  . PRO A 1 137 ? 133.296 108.489 109.496 1.00 39.65  ? 137 PRO A CB  1 
ATOM   827  C CG  . PRO A 1 137 ? 133.896 108.584 110.838 1.00 39.65  ? 137 PRO A CG  1 
ATOM   828  C CD  . PRO A 1 137 ? 133.043 109.553 111.586 1.00 39.65  ? 137 PRO A CD  1 
ATOM   829  N N   . ILE A 1 138 ? 130.452 109.711 108.725 1.00 41.05  ? 138 ILE A N   1 
ATOM   830  C CA  . ILE A 1 138 ? 129.295 109.740 107.837 1.00 41.05  ? 138 ILE A CA  1 
ATOM   831  C C   . ILE A 1 138 ? 129.075 111.147 107.297 1.00 41.05  ? 138 ILE A C   1 
ATOM   832  O O   . ILE A 1 138 ? 128.816 111.338 106.101 1.00 41.05  ? 138 ILE A O   1 
ATOM   833  C CB  . ILE A 1 138 ? 128.045 109.213 108.563 1.00 41.05  ? 138 ILE A CB  1 
ATOM   834  C CG1 . ILE A 1 138 ? 128.396 108.007 109.430 1.00 41.05  ? 138 ILE A CG1 1 
ATOM   835  C CG2 . ILE A 1 138 ? 126.978 108.823 107.562 1.00 41.05  ? 138 ILE A CG2 1 
ATOM   836  C CD1 . ILE A 1 138 ? 127.285 107.602 110.366 1.00 41.05  ? 138 ILE A CD1 1 
ATOM   837  N N   . LEU A 1 139 ? 129.182 112.153 108.165 1.00 39.42  ? 139 LEU A N   1 
ATOM   838  C CA  . LEU A 1 139 ? 129.025 113.531 107.717 1.00 39.42  ? 139 LEU A CA  1 
ATOM   839  C C   . LEU A 1 139 ? 130.141 113.923 106.762 1.00 39.42  ? 139 LEU A C   1 
ATOM   840  O O   . LEU A 1 139 ? 129.910 114.672 105.809 1.00 39.42  ? 139 LEU A O   1 
ATOM   841  C CB  . LEU A 1 139 ? 128.980 114.482 108.910 1.00 39.42  ? 139 LEU A CB  1 
ATOM   842  C CG  . LEU A 1 139 ? 128.017 114.129 110.041 1.00 39.42  ? 139 LEU A CG  1 
ATOM   843  C CD1 . LEU A 1 139 ? 127.846 115.309 110.972 1.00 39.42  ? 139 LEU A CD1 1 
ATOM   844  C CD2 . LEU A 1 139 ? 126.675 113.659 109.511 1.00 39.42  ? 139 LEU A CD2 1 
ATOM   845  N N   . GLY A 1 140 ? 131.358 113.435 107.004 1.00 41.89  ? 140 GLY A N   1 
ATOM   846  C CA  . GLY A 1 140 ? 132.441 113.700 106.072 1.00 41.89  ? 140 GLY A CA  1 
ATOM   847  C C   . GLY A 1 140 ? 132.189 113.106 104.699 1.00 41.89  ? 140 GLY A C   1 
ATOM   848  O O   . GLY A 1 140 ? 132.413 113.760 103.677 1.00 41.89  ? 140 GLY A O   1 
ATOM   849  N N   . LYS A 1 141 ? 131.715 111.859 104.656 1.00 42.03  ? 141 LYS A N   1 
ATOM   850  C CA  . LYS A 1 141 ? 131.389 111.239 103.375 1.00 42.03  ? 141 LYS A CA  1 
ATOM   851  C C   . LYS A 1 141 ? 130.288 112.010 102.659 1.00 42.03  ? 141 LYS A C   1 
ATOM   852  O O   . LYS A 1 141 ? 130.360 112.228 101.443 1.00 42.03  ? 141 LYS A O   1 
ATOM   853  C CB  . LYS A 1 141 ? 130.976 109.785 103.583 1.00 42.03  ? 141 LYS A CB  1 
ATOM   854  C CG  . LYS A 1 141 ? 132.112 108.868 103.972 1.00 42.03  ? 141 LYS A CG  1 
ATOM   855  C CD  . LYS A 1 141 ? 131.614 107.455 104.193 1.00 42.03  ? 141 LYS A CD  1 
ATOM   856  C CE  . LYS A 1 141 ? 130.903 107.328 105.530 1.00 42.03  ? 141 LYS A CE  1 
ATOM   857  N NZ  . LYS A 1 141 ? 130.642 105.908 105.892 1.00 42.03  ? 141 LYS A NZ  1 
ATOM   858  N N   . SER A 1 142 ? 129.259 112.432 103.398 1.00 41.37  ? 142 SER A N   1 
ATOM   859  C CA  . SER A 1 142 ? 128.178 113.195 102.783 1.00 41.37  ? 142 SER A CA  1 
ATOM   860  C C   . SER A 1 142 ? 128.670 114.545 102.274 1.00 41.37  ? 142 SER A C   1 
ATOM   861  O O   . SER A 1 142 ? 128.235 115.009 101.214 1.00 41.37  ? 142 SER A O   1 
ATOM   862  C CB  . SER A 1 142 ? 127.035 113.376 103.775 1.00 41.37  ? 142 SER A CB  1 
ATOM   863  O OG  . SER A 1 142 ? 126.238 112.208 103.842 1.00 41.37  ? 142 SER A OG  1 
ATOM   864  N N   . TRP A 1 143 ? 129.568 115.193 103.019 1.00 44.03  ? 143 TRP A N   1 
ATOM   865  C CA  . TRP A 1 143 ? 130.136 116.458 102.567 1.00 44.03  ? 143 TRP A CA  1 
ATOM   866  C C   . TRP A 1 143 ? 130.953 116.269 101.298 1.00 44.03  ? 143 TRP A C   1 
ATOM   867  O O   . TRP A 1 143 ? 130.878 117.091 100.375 1.00 44.03  ? 143 TRP A O   1 
ATOM   868  C CB  . TRP A 1 143 ? 130.994 117.065 103.674 1.00 44.03  ? 143 TRP A CB  1 
ATOM   869  C CG  . TRP A 1 143 ? 131.621 118.370 103.319 1.00 44.03  ? 143 TRP A CG  1 
ATOM   870  C CD1 . TRP A 1 143 ? 130.984 119.553 103.109 1.00 44.03  ? 143 TRP A CD1 1 
ATOM   871  C CD2 . TRP A 1 143 ? 133.017 118.629 103.147 1.00 44.03  ? 143 TRP A CD2 1 
ATOM   872  N NE1 . TRP A 1 143 ? 131.895 120.533 102.809 1.00 44.03  ? 143 TRP A NE1 1 
ATOM   873  C CE2 . TRP A 1 143 ? 133.151 119.990 102.826 1.00 44.03  ? 143 TRP A CE2 1 
ATOM   874  C CE3 . TRP A 1 143 ? 134.167 117.839 103.228 1.00 44.03  ? 143 TRP A CE3 1 
ATOM   875  C CZ2 . TRP A 1 143 ? 134.387 120.581 102.586 1.00 44.03  ? 143 TRP A CZ2 1 
ATOM   876  C CZ3 . TRP A 1 143 ? 135.393 118.426 102.991 1.00 44.03  ? 143 TRP A CZ3 1 
ATOM   877  C CH2 . TRP A 1 143 ? 135.494 119.785 102.674 1.00 44.03  ? 143 TRP A CH2 1 
ATOM   878  N N   . ARG A 1 144 ? 131.761 115.229 101.193 1.00 45.77  ? 144 ARG A N   1 
ATOM   879  C CA  . ARG A 1 144 ? 132.420 115.019 99.905  1.00 45.77  ? 144 ARG A CA  1 
ATOM   880  C C   . ARG A 1 144 ? 131.392 114.809 98.830  1.00 45.77  ? 144 ARG A C   1 
ATOM   881  O O   . ARG A 1 144 ? 131.433 115.456 97.801  1.00 45.77  ? 144 ARG A O   1 
ATOM   882  C CB  . ARG A 1 144 ? 133.354 113.850 99.917  1.00 45.77  ? 144 ARG A CB  1 
ATOM   883  C CG  . ARG A 1 144 ? 133.825 113.434 98.540  1.00 45.77  ? 144 ARG A CG  1 
ATOM   884  C CD  . ARG A 1 144 ? 135.070 112.577 98.637  1.00 45.77  ? 144 ARG A CD  1 
ATOM   885  N NE  . ARG A 1 144 ? 134.879 111.431 99.512  1.00 45.77  ? 144 ARG A NE  1 
ATOM   886  C CZ  . ARG A 1 144 ? 135.858 110.622 99.892  1.00 45.77  ? 144 ARG A CZ  1 
ATOM   887  N NH1 . ARG A 1 144 ? 135.604 109.599 100.691 1.00 45.77  ? 144 ARG A NH1 1 
ATOM   888  N NH2 . ARG A 1 144 ? 137.097 110.842 99.479  1.00 45.77  ? 144 ARG A NH2 1 
ATOM   889  N N   . LEU A 1 145 ? 130.443 113.917 99.060  1.00 45.39  ? 145 LEU A N   1 
ATOM   890  C CA  . LEU A 1 145 ? 129.486 113.636 97.995  1.00 45.39  ? 145 LEU A CA  1 
ATOM   891  C C   . LEU A 1 145 ? 128.839 114.919 97.490  1.00 45.39  ? 145 LEU A C   1 
ATOM   892  O O   . LEU A 1 145 ? 128.736 115.144 96.278  1.00 45.39  ? 145 LEU A O   1 
ATOM   893  C CB  . LEU A 1 145 ? 128.433 112.655 98.507  1.00 45.39  ? 145 LEU A CB  1 
ATOM   894  C CG  . LEU A 1 145 ? 127.385 112.159 97.522  1.00 45.39  ? 145 LEU A CG  1 
ATOM   895  C CD1 . LEU A 1 145 ? 128.067 111.386 96.415  1.00 45.39  ? 145 LEU A CD1 1 
ATOM   896  C CD2 . LEU A 1 145 ? 126.371 111.290 98.236  1.00 45.39  ? 145 LEU A CD2 1 
ATOM   897  N N   . TYR A 1 146 ? 128.380 115.762 98.416  1.00 46.67  ? 146 TYR A N   1 
ATOM   898  C CA  . TYR A 1 146 ? 127.876 117.088 98.080  1.00 46.67  ? 146 TYR A CA  1 
ATOM   899  C C   . TYR A 1 146 ? 128.868 117.852 97.213  1.00 46.67  ? 146 TYR A C   1 
ATOM   900  O O   . TYR A 1 146 ? 128.568 118.229 96.072  1.00 46.67  ? 146 TYR A O   1 
ATOM   901  C CB  . TYR A 1 146 ? 127.584 117.851 99.375  1.00 46.67  ? 146 TYR A CB  1 
ATOM   902  C CG  . TYR A 1 146 ? 127.405 119.343 99.223  1.00 46.67  ? 146 TYR A CG  1 
ATOM   903  C CD1 . TYR A 1 146 ? 126.234 119.873 98.716  1.00 46.67  ? 146 TYR A CD1 1 
ATOM   904  C CD2 . TYR A 1 146 ? 128.405 120.221 99.612  1.00 46.67  ? 146 TYR A CD2 1 
ATOM   905  C CE1 . TYR A 1 146 ? 126.067 121.233 98.580  1.00 46.67  ? 146 TYR A CE1 1 
ATOM   906  C CE2 . TYR A 1 146 ? 128.246 121.583 99.483  1.00 46.67  ? 146 TYR A CE2 1 
ATOM   907  C CZ  . TYR A 1 146 ? 127.074 122.084 98.967  1.00 46.67  ? 146 TYR A CZ  1 
ATOM   908  O OH  . TYR A 1 146 ? 126.910 123.444 98.835  1.00 46.67  ? 146 TYR A OH  1 
ATOM   909  N N   . LYS A 1 147 ? 130.077 118.058 97.740  1.00 50.32  ? 147 LYS A N   1 
ATOM   910  C CA  . LYS A 1 147 ? 131.061 118.908 97.086  1.00 50.32  ? 147 LYS A CA  1 
ATOM   911  C C   . LYS A 1 147 ? 131.534 118.339 95.752  1.00 50.32  ? 147 LYS A C   1 
ATOM   912  O O   . LYS A 1 147 ? 132.031 119.096 94.913  1.00 50.32  ? 147 LYS A O   1 
ATOM   913  C CB  . LYS A 1 147 ? 132.241 119.130 98.035  1.00 50.32  ? 147 LYS A CB  1 
ATOM   914  C CG  . LYS A 1 147 ? 133.342 120.028 97.499  1.00 50.32  ? 147 LYS A CG  1 
ATOM   915  C CD  . LYS A 1 147 ? 132.868 121.468 97.389  1.00 50.32  ? 147 LYS A CD  1 
ATOM   916  C CE  . LYS A 1 147 ? 133.998 122.388 96.956  1.00 50.32  ? 147 LYS A CE  1 
ATOM   917  N NZ  . LYS A 1 147 ? 133.535 123.792 96.778  1.00 50.32  ? 147 LYS A NZ  1 
ATOM   918  N N   . VAL A 1 148 ? 131.381 117.037 95.521  1.00 50.99  ? 148 VAL A N   1 
ATOM   919  C CA  . VAL A 1 148 ? 131.889 116.449 94.288  1.00 50.99  ? 148 VAL A CA  1 
ATOM   920  C C   . VAL A 1 148 ? 130.798 116.230 93.243  1.00 50.99  ? 148 VAL A C   1 
ATOM   921  O O   . VAL A 1 148 ? 131.116 116.147 92.047  1.00 50.99  ? 148 VAL A O   1 
ATOM   922  C CB  . VAL A 1 148 ? 132.621 115.119 94.571  1.00 50.99  ? 148 VAL A CB  1 
ATOM   923  C CG1 . VAL A 1 148 ? 131.627 114.002 94.867  1.00 50.99  ? 148 VAL A CG1 1 
ATOM   924  C CG2 . VAL A 1 148 ? 133.543 114.746 93.414  1.00 50.99  ? 148 VAL A CG2 1 
ATOM   925  N N   . PHE A 1 149 ? 129.552 116.328 93.649  1.00 52.34  ? 149 PHE A N   1 
ATOM   926  C CA  . PHE A 1 149 ? 128.453 116.184 92.724  1.00 52.34  ? 149 PHE A CA  1 
ATOM   927  C C   . PHE A 1 149 ? 127.812 117.493 92.338  1.00 52.34  ? 149 PHE A C   1 
ATOM   928  O O   . PHE A 1 149 ? 127.599 117.749 91.162  1.00 52.34  ? 149 PHE A O   1 
ATOM   929  C CB  . PHE A 1 149 ? 127.366 115.300 93.297  1.00 52.34  ? 149 PHE A CB  1 
ATOM   930  C CG  . PHE A 1 149 ? 127.591 113.836 93.067  1.00 52.34  ? 149 PHE A CG  1 
ATOM   931  C CD1 . PHE A 1 149 ? 128.772 113.234 93.460  1.00 52.34  ? 149 PHE A CD1 1 
ATOM   932  C CD2 . PHE A 1 149 ? 126.617 113.060 92.463  1.00 52.34  ? 149 PHE A CD2 1 
ATOM   933  C CE1 . PHE A 1 149 ? 128.983 111.886 93.248  1.00 52.34  ? 149 PHE A CE1 1 
ATOM   934  C CE2 . PHE A 1 149 ? 126.819 111.711 92.251  1.00 52.34  ? 149 PHE A CE2 1 
ATOM   935  C CZ  . PHE A 1 149 ? 128.004 111.122 92.645  1.00 52.34  ? 149 PHE A CZ  1 
ATOM   936  N N   . THR A 1 150 ? 127.489 118.322 93.304  1.00 55.15  ? 150 THR A N   1 
ATOM   937  C CA  . THR A 1 150 ? 126.814 119.582 93.008  1.00 55.15  ? 150 THR A CA  1 
ATOM   938  C C   . THR A 1 150 ? 127.746 120.785 93.109  1.00 55.15  ? 150 THR A C   1 
ATOM   939  O O   . THR A 1 150 ? 127.299 121.897 93.404  1.00 55.15  ? 150 THR A O   1 
ATOM   940  C CB  . THR A 1 150 ? 125.592 119.769 93.906  1.00 55.15  ? 150 THR A CB  1 
ATOM   941  O OG1 . THR A 1 150 ? 124.938 121.001 93.575  1.00 55.15  ? 150 THR A OG1 1 
ATOM   942  C CG2 . THR A 1 150 ? 125.989 119.792 95.359  1.00 55.15  ? 150 THR A CG2 1 
ATOM   943  N N   . GLN A 1 151 ? 129.035 120.582 92.859  1.00 59.03  ? 151 GLN A N   1 
ATOM   944  C CA  . GLN A 1 151 ? 130.014 121.656 92.727  1.00 59.03  ? 151 GLN A CA  1 
ATOM   945  C C   . GLN A 1 151 ? 130.891 121.413 91.505  1.00 59.03  ? 151 GLN A C   1 
ATOM   946  O O   . GLN A 1 151 ? 132.121 121.465 91.560  1.00 59.03  ? 151 GLN A O   1 
ATOM   947  C CB  . GLN A 1 151 ? 130.859 121.799 93.988  1.00 59.03  ? 151 GLN A CB  1 
ATOM   948  C CG  . GLN A 1 151 ? 130.349 122.849 94.960  1.00 59.03  ? 151 GLN A CG  1 
ATOM   949  C CD  . GLN A 1 151 ? 129.187 122.356 95.796  1.00 59.03  ? 151 GLN A CD  1 
ATOM   950  O OE1 . GLN A 1 151 ? 128.964 121.153 95.922  1.00 59.03  ? 151 GLN A OE1 1 
ATOM   951  N NE2 . GLN A 1 151 ? 128.436 123.288 96.371  1.00 59.03  ? 151 GLN A NE2 1 
ATOM   952  N N   . ARG A 1 152 ? 130.250 121.131 90.374  1.00 72.21  ? 152 ARG A N   1 
ATOM   953  C CA  . ARG A 1 152 ? 130.945 120.933 89.102  1.00 72.21  ? 152 ARG A CA  1 
ATOM   954  C C   . ARG A 1 152 ? 131.228 122.264 88.398  1.00 72.21  ? 152 ARG A C   1 
ATOM   955  O O   . ARG A 1 152 ? 130.982 122.464 87.209  1.00 72.21  ? 152 ARG A O   1 
ATOM   956  C CB  . ARG A 1 152 ? 130.145 119.962 88.231  1.00 72.21  ? 152 ARG A CB  1 
ATOM   957  C CG  . ARG A 1 152 ? 128.928 120.510 87.470  1.00 72.21  ? 152 ARG A CG  1 
ATOM   958  C CD  . ARG A 1 152 ? 127.789 120.909 88.395  1.00 72.21  ? 152 ARG A CD  1 
ATOM   959  N NE  . ARG A 1 152 ? 126.618 121.358 87.652  1.00 72.21  ? 152 ARG A NE  1 
ATOM   960  C CZ  . ARG A 1 152 ? 126.449 122.591 87.194  1.00 72.21  ? 152 ARG A CZ  1 
ATOM   961  N NH1 . ARG A 1 152 ? 127.360 123.531 87.386  1.00 72.21  ? 152 ARG A NH1 1 
ATOM   962  N NH2 . ARG A 1 152 ? 125.338 122.888 86.526  1.00 72.21  ? 152 ARG A NH2 1 
ATOM   963  N N   . VAL A 1 153 ? 131.831 123.180 89.151  1.00 79.26  ? 153 VAL A N   1 
ATOM   964  C CA  . VAL A 1 153 ? 132.166 124.517 88.665  1.00 79.26  ? 153 VAL A CA  1 
ATOM   965  C C   . VAL A 1 153 ? 133.240 124.402 87.589  1.00 79.26  ? 153 VAL A C   1 
ATOM   966  O O   . VAL A 1 153 ? 133.925 123.371 87.514  1.00 79.26  ? 153 VAL A O   1 
ATOM   967  C CB  . VAL A 1 153 ? 132.624 125.422 89.820  1.00 79.26  ? 153 VAL A CB  1 
ATOM   968  C CG1 . VAL A 1 153 ? 131.448 125.766 90.720  1.00 79.26  ? 153 VAL A CG1 1 
ATOM   969  C CG2 . VAL A 1 153 ? 133.724 124.747 90.616  1.00 79.26  ? 153 VAL A CG2 1 
ATOM   970  N N   . PRO A 1 154 ? 133.400 125.409 86.722  1.00 83.73  ? 154 PRO A N   1 
ATOM   971  C CA  . PRO A 1 154 ? 134.439 125.332 85.678  1.00 83.73  ? 154 PRO A CA  1 
ATOM   972  C C   . PRO A 1 154 ? 135.810 124.927 86.191  1.00 83.73  ? 154 PRO A C   1 
ATOM   973  O O   . PRO A 1 154 ? 136.553 124.247 85.472  1.00 83.73  ? 154 PRO A O   1 
ATOM   974  C CB  . PRO A 1 154 ? 134.452 126.753 85.104  1.00 83.73  ? 154 PRO A CB  1 
ATOM   975  C CG  . PRO A 1 154 ? 133.063 127.250 85.305  1.00 83.73  ? 154 PRO A CG  1 
ATOM   976  C CD  . PRO A 1 154 ? 132.495 126.556 86.519  1.00 83.73  ? 154 PRO A CD  1 
ATOM   977  N N   . ASP A 1 155 ? 136.171 125.318 87.411  1.00 87.28  ? 155 ASP A N   1 
ATOM   978  C CA  . ASP A 1 155 ? 137.393 124.827 88.037  1.00 87.28  ? 155 ASP A CA  1 
ATOM   979  C C   . ASP A 1 155 ? 137.100 123.451 88.618  1.00 87.28  ? 155 ASP A C   1 
ATOM   980  O O   . ASP A 1 155 ? 136.428 123.334 89.648  1.00 87.28  ? 155 ASP A O   1 
ATOM   981  C CB  . ASP A 1 155 ? 137.875 125.796 89.113  1.00 87.28  ? 155 ASP A CB  1 
ATOM   982  C CG  . ASP A 1 155 ? 139.233 125.417 89.672  1.00 87.28  ? 155 ASP A CG  1 
ATOM   983  O OD1 . ASP A 1 155 ? 140.000 124.734 88.962  1.00 87.28  ? 155 ASP A OD1 1 
ATOM   984  O OD2 . ASP A 1 155 ? 139.533 125.802 90.822  1.00 87.28  ? 155 ASP A OD2 1 
ATOM   985  N N   . LYS A 1 156 ? 137.599 122.409 87.958  1.00 84.24  ? 156 LYS A N   1 
ATOM   986  C CA  . LYS A 1 156 ? 137.221 121.047 88.310  1.00 84.24  ? 156 LYS A CA  1 
ATOM   987  C C   . LYS A 1 156 ? 137.672 120.696 89.721  1.00 84.24  ? 156 LYS A C   1 
ATOM   988  O O   . LYS A 1 156 ? 138.794 121.003 90.130  1.00 84.24  ? 156 LYS A O   1 
ATOM   989  C CB  . LYS A 1 156 ? 137.821 120.056 87.312  1.00 84.24  ? 156 LYS A CB  1 
ATOM   990  C CG  . LYS A 1 156 ? 137.622 118.598 87.701  1.00 84.24  ? 156 LYS A CG  1 
ATOM   991  C CD  . LYS A 1 156 ? 138.644 117.692 87.036  1.00 84.24  ? 156 LYS A CD  1 
ATOM   992  C CE  . LYS A 1 156 ? 138.574 116.283 87.603  1.00 84.24  ? 156 LYS A CE  1 
ATOM   993  N NZ  . LYS A 1 156 ? 139.614 115.396 87.016  1.00 84.24  ? 156 LYS A NZ  1 
ATOM   994  N N   . ARG A 1 157 ? 136.781 120.047 90.467  1.00 81.99  ? 157 ARG A N   1 
ATOM   995  C CA  . ARG A 1 157 ? 137.129 119.463 91.760  1.00 81.99  ? 157 ARG A CA  1 
ATOM   996  C C   . ARG A 1 157 ? 137.934 118.203 91.475  1.00 81.99  ? 157 ARG A C   1 
ATOM   997  O O   . ARG A 1 157 ? 137.391 117.103 91.364  1.00 81.99  ? 157 ARG A O   1 
ATOM   998  C CB  . ARG A 1 157 ? 135.881 119.162 92.579  1.00 81.99  ? 157 ARG A CB  1 
ATOM   999  C CG  . ARG A 1 157 ? 136.169 118.580 93.952  1.00 81.99  ? 157 ARG A CG  1 
ATOM   1000 C CD  . ARG A 1 157 ? 137.047 119.508 94.769  1.00 81.99  ? 157 ARG A CD  1 
ATOM   1001 N NE  . ARG A 1 157 ? 138.439 119.075 94.786  1.00 81.99  ? 157 ARG A NE  1 
ATOM   1002 C CZ  . ARG A 1 157 ? 139.452 119.831 95.185  1.00 81.99  ? 157 ARG A CZ  1 
ATOM   1003 N NH1 . ARG A 1 157 ? 139.265 121.069 95.612  1.00 81.99  ? 157 ARG A NH1 1 
ATOM   1004 N NH2 . ARG A 1 157 ? 140.685 119.332 95.155  1.00 81.99  ? 157 ARG A NH2 1 
ATOM   1005 N N   . VAL A 1 158 ? 139.250 118.376 91.337  1.00 82.57  ? 158 VAL A N   1 
ATOM   1006 C CA  . VAL A 1 158 ? 140.108 117.281 90.885  1.00 82.57  ? 158 VAL A CA  1 
ATOM   1007 C C   . VAL A 1 158 ? 140.046 116.119 91.868  1.00 82.57  ? 158 VAL A C   1 
ATOM   1008 O O   . VAL A 1 158 ? 139.592 115.019 91.531  1.00 82.57  ? 158 VAL A O   1 
ATOM   1009 C CB  . VAL A 1 158 ? 141.552 117.773 90.689  1.00 82.57  ? 158 VAL A CB  1 
ATOM   1010 C CG1 . VAL A 1 158 ? 142.380 116.716 89.975  1.00 82.57  ? 158 VAL A CG1 1 
ATOM   1011 C CG2 . VAL A 1 158 ? 141.565 119.082 89.915  1.00 82.57  ? 158 VAL A CG2 1 
ATOM   1012 N N   . ILE A 1 159 ? 140.486 116.351 93.101  1.00 75.66  ? 159 ILE A N   1 
ATOM   1013 C CA  . ILE A 1 159 ? 140.503 115.322 94.134  1.00 75.66  ? 159 ILE A CA  1 
ATOM   1014 C C   . ILE A 1 159 ? 140.181 115.957 95.478  1.00 75.66  ? 159 ILE A C   1 
ATOM   1015 O O   . ILE A 1 159 ? 140.674 117.042 95.805  1.00 75.66  ? 159 ILE A O   1 
ATOM   1016 C CB  . ILE A 1 159 ? 141.861 114.583 94.194  1.00 75.66  ? 159 ILE A CB  1 
ATOM   1017 C CG1 . ILE A 1 159 ? 143.017 115.575 94.350  1.00 75.66  ? 159 ILE A CG1 1 
ATOM   1018 C CG2 . ILE A 1 159 ? 142.059 113.679 92.980  1.00 75.66  ? 159 ILE A CG2 1 
ATOM   1019 C CD1 . ILE A 1 159 ? 144.353 114.917 94.619  1.00 75.66  ? 159 ILE A CD1 1 
ATOM   1020 N N   . ILE A 1 160 ? 139.335 115.281 96.249  1.00 64.59  ? 160 ILE A N   1 
ATOM   1021 C CA  . ILE A 1 160 ? 139.128 115.580 97.666  1.00 64.59  ? 160 ILE A CA  1 
ATOM   1022 C C   . ILE A 1 160 ? 139.339 114.266 98.418  1.00 64.59  ? 160 ILE A C   1 
ATOM   1023 O O   . ILE A 1 160 ? 138.417 113.467 98.605  1.00 64.59  ? 160 ILE A O   1 
ATOM   1024 C CB  . ILE A 1 160 ? 137.757 116.212 97.948  1.00 64.59  ? 160 ILE A CB  1 
ATOM   1025 C CG1 . ILE A 1 160 ? 137.667 116.722 99.391  1.00 64.59  ? 160 ILE A CG1 1 
ATOM   1026 C CG2 . ILE A 1 160 ? 136.580 115.359 97.447  1.00 64.59  ? 160 ILE A CG2 1 
ATOM   1027 C CD1 . ILE A 1 160 ? 136.488 117.625 99.638  1.00 64.59  ? 160 ILE A CD1 1 
ATOM   1028 N N   . LYS A 1 161 ? 140.575 114.032 98.846  1.00 64.61  ? 161 LYS A N   1 
ATOM   1029 C CA  . LYS A 1 161 ? 140.994 112.715 99.294  1.00 64.61  ? 161 LYS A CA  1 
ATOM   1030 C C   . LYS A 1 161 ? 140.426 112.399 100.673 1.00 64.61  ? 161 LYS A C   1 
ATOM   1031 O O   . LYS A 1 161 ? 139.868 113.255 101.365 1.00 64.61  ? 161 LYS A O   1 
ATOM   1032 C CB  . LYS A 1 161 ? 142.519 112.623 99.314  1.00 64.61  ? 161 LYS A CB  1 
ATOM   1033 C CG  . LYS A 1 161 ? 143.158 112.753 97.943  1.00 64.61  ? 161 LYS A CG  1 
ATOM   1034 C CD  . LYS A 1 161 ? 144.580 113.271 98.048  1.00 64.61  ? 161 LYS A CD  1 
ATOM   1035 C CE  . LYS A 1 161 ? 144.618 114.629 98.727  1.00 64.61  ? 161 LYS A CE  1 
ATOM   1036 N NZ  . LYS A 1 161 ? 144.081 115.704 97.849  1.00 64.61  ? 161 LYS A NZ  1 
ATOM   1037 N N   . ASP A 1 162 ? 140.642 111.165 101.113 1.00 58.91  ? 162 ASP A N   1 
ATOM   1038 C CA  . ASP A 1 162 ? 140.162 110.752 102.431 1.00 58.91  ? 162 ASP A CA  1 
ATOM   1039 C C   . ASP A 1 162 ? 140.895 111.484 103.517 1.00 58.91  ? 162 ASP A C   1 
ATOM   1040 O O   . ASP A 1 162 ? 140.358 111.719 104.593 1.00 58.91  ? 162 ASP A O   1 
ATOM   1041 C CB  . ASP A 1 162 ? 140.348 109.258 102.619 1.00 58.91  ? 162 ASP A CB  1 
ATOM   1042 C CG  . ASP A 1 162 ? 139.603 108.446 101.586 1.00 58.91  ? 162 ASP A CG  1 
ATOM   1043 O OD1 . ASP A 1 162 ? 139.186 109.021 100.561 1.00 58.91  ? 162 ASP A OD1 1 
ATOM   1044 O OD2 . ASP A 1 162 ? 139.439 107.226 101.796 1.00 58.91  ? 162 ASP A OD2 1 
ATOM   1045 N N   . LEU A 1 163 ? 142.119 111.868 103.237 1.00 58.27  ? 163 LEU A N   1 
ATOM   1046 C CA  . LEU A 1 163 ? 142.920 112.534 104.258 1.00 58.27  ? 163 LEU A CA  1 
ATOM   1047 C C   . LEU A 1 163 ? 142.226 113.771 104.813 1.00 58.27  ? 163 LEU A C   1 
ATOM   1048 O O   . LEU A 1 163 ? 142.304 114.046 106.014 1.00 58.27  ? 163 LEU A O   1 
ATOM   1049 C CB  . LEU A 1 163 ? 144.288 112.900 103.684 1.00 58.27  ? 163 LEU A CB  1 
ATOM   1050 C CG  . LEU A 1 163 ? 145.146 111.715 103.240 1.00 58.27  ? 163 LEU A CG  1 
ATOM   1051 C CD1 . LEU A 1 163 ? 145.133 111.581 101.728 1.00 58.27  ? 163 LEU A CD1 1 
ATOM   1052 C CD2 . LEU A 1 163 ? 146.568 111.858 103.756 1.00 58.27  ? 163 LEU A CD2 1 
ATOM   1053 N N   . GLN A 1 164 ? 141.528 114.522 103.960 1.00 59.01  ? 164 GLN A N   1 
ATOM   1054 C CA  . GLN A 1 164 ? 140.841 115.717 104.440 1.00 59.01  ? 164 GLN A CA  1 
ATOM   1055 C C   . GLN A 1 164 ? 139.710 115.361 105.396 1.00 59.01  ? 164 GLN A C   1 
ATOM   1056 O O   . GLN A 1 164 ? 139.536 116.012 106.434 1.00 59.01  ? 164 GLN A O   1 
ATOM   1057 C CB  . GLN A 1 164 ? 140.308 116.528 103.261 1.00 59.01  ? 164 GLN A CB  1 
ATOM   1058 C CG  . GLN A 1 164 ? 141.374 117.292 102.500 1.00 59.01  ? 164 GLN A CG  1 
ATOM   1059 C CD  . GLN A 1 164 ? 140.788 118.196 101.434 1.00 59.01  ? 164 GLN A CD  1 
ATOM   1060 O OE1 . GLN A 1 164 ? 139.626 118.597 101.513 1.00 59.01  ? 164 GLN A OE1 1 
ATOM   1061 N NE2 . GLN A 1 164 ? 141.590 118.518 100.427 1.00 59.01  ? 164 GLN A NE2 1 
ATOM   1062 N N   . LEU A 1 165 ? 138.927 114.333 105.064 1.00 51.89  ? 165 LEU A N   1 
ATOM   1063 C CA  . LEU A 1 165 ? 137.845 113.920 105.951 1.00 51.89  ? 165 LEU A CA  1 
ATOM   1064 C C   . LEU A 1 165 ? 138.387 113.361 107.258 1.00 51.89  ? 165 LEU A C   1 
ATOM   1065 O O   . LEU A 1 165 ? 137.815 113.604 108.328 1.00 51.89  ? 165 LEU A O   1 
ATOM   1066 C CB  . LEU A 1 165 ? 136.952 112.904 105.251 1.00 51.89  ? 165 LEU A CB  1 
ATOM   1067 C CG  . LEU A 1 165 ? 136.387 113.473 103.954 1.00 51.89  ? 165 LEU A CG  1 
ATOM   1068 C CD1 . LEU A 1 165 ? 135.802 112.373 103.091 1.00 51.89  ? 165 LEU A CD1 1 
ATOM   1069 C CD2 . LEU A 1 165 ? 135.382 114.576 104.226 1.00 51.89  ? 165 LEU A CD2 1 
ATOM   1070 N N   . LEU A 1 166 ? 139.475 112.592 107.190 1.00 51.72  ? 166 LEU A N   1 
ATOM   1071 C CA  . LEU A 1 166 ? 140.115 112.126 108.414 1.00 51.72  ? 166 LEU A CA  1 
ATOM   1072 C C   . LEU A 1 166 ? 140.599 113.297 109.254 1.00 51.72  ? 166 LEU A C   1 
ATOM   1073 O O   . LEU A 1 166 ? 140.515 113.261 110.484 1.00 51.72  ? 166 LEU A O   1 
ATOM   1074 C CB  . LEU A 1 166 ? 141.271 111.177 108.097 1.00 51.72  ? 166 LEU A CB  1 
ATOM   1075 C CG  . LEU A 1 166 ? 140.960 109.699 107.836 1.00 51.72  ? 166 LEU A CG  1 
ATOM   1076 C CD1 . LEU A 1 166 ? 140.381 109.070 109.095 1.00 51.72  ? 166 LEU A CD1 1 
ATOM   1077 C CD2 . LEU A 1 166 ? 140.030 109.475 106.658 1.00 51.72  ? 166 LEU A CD2 1 
ATOM   1078 N N   . GLY A 1 167 ? 141.101 114.350 108.609 1.00 49.25  ? 167 GLY A N   1 
ATOM   1079 C CA  . GLY A 1 167 ? 141.508 115.530 109.351 1.00 49.25  ? 167 GLY A CA  1 
ATOM   1080 C C   . GLY A 1 167 ? 140.341 116.227 110.021 1.00 49.25  ? 167 GLY A C   1 
ATOM   1081 O O   . GLY A 1 167 ? 140.452 116.688 111.159 1.00 49.25  ? 167 GLY A O   1 
ATOM   1082 N N   . LEU A 1 168 ? 139.208 116.319 109.324 1.00 48.54  ? 168 LEU A N   1 
ATOM   1083 C CA  . LEU A 1 168 ? 138.019 116.916 109.926 1.00 48.54  ? 168 LEU A CA  1 
ATOM   1084 C C   . LEU A 1 168 ? 137.539 116.103 111.124 1.00 48.54  ? 168 LEU A C   1 
ATOM   1085 O O   . LEU A 1 168 ? 137.197 116.664 112.175 1.00 48.54  ? 168 LEU A O   1 
ATOM   1086 C CB  . LEU A 1 168 ? 136.912 117.034 108.879 1.00 48.54  ? 168 LEU A CB  1 
ATOM   1087 C CG  . LEU A 1 168 ? 136.778 118.343 108.098 1.00 48.54  ? 168 LEU A CG  1 
ATOM   1088 C CD1 . LEU A 1 168 ? 138.018 118.640 107.277 1.00 48.54  ? 168 LEU A CD1 1 
ATOM   1089 C CD2 . LEU A 1 168 ? 135.556 118.279 107.199 1.00 48.54  ? 168 LEU A CD2 1 
ATOM   1090 N N   . VAL A 1 169 ? 137.518 114.776 110.986 1.00 45.58  ? 169 VAL A N   1 
ATOM   1091 C CA  . VAL A 1 169 ? 137.118 113.915 112.096 1.00 45.58  ? 169 VAL A CA  1 
ATOM   1092 C C   . VAL A 1 169 ? 138.099 114.049 113.253 1.00 45.58  ? 169 VAL A C   1 
ATOM   1093 O O   . VAL A 1 169 ? 137.705 114.051 114.424 1.00 45.58  ? 169 VAL A O   1 
ATOM   1094 C CB  . VAL A 1 169 ? 136.991 112.456 111.624 1.00 45.58  ? 169 VAL A CB  1 
ATOM   1095 C CG1 . VAL A 1 169 ? 136.735 111.539 112.804 1.00 45.58  ? 169 VAL A CG1 1 
ATOM   1096 C CG2 . VAL A 1 169 ? 135.877 112.332 110.601 1.00 45.58  ? 169 VAL A CG2 1 
ATOM   1097 N N   . ALA A 1 170 ? 139.393 114.160 112.943 1.00 44.95  ? 170 ALA A N   1 
ATOM   1098 C CA  . ALA A 1 170 ? 140.399 114.336 113.982 1.00 44.95  ? 170 ALA A CA  1 
ATOM   1099 C C   . ALA A 1 170 ? 140.215 115.658 114.710 1.00 44.95  ? 170 ALA A C   1 
ATOM   1100 O O   . ALA A 1 170 ? 140.399 115.731 115.927 1.00 44.95  ? 170 ALA A O   1 
ATOM   1101 C CB  . ALA A 1 170 ? 141.797 114.246 113.376 1.00 44.95  ? 170 ALA A CB  1 
ATOM   1102 N N   . ALA A 1 171 ? 139.866 116.718 113.981 1.00 44.42  ? 171 ALA A N   1 
ATOM   1103 C CA  . ALA A 1 171 ? 139.605 118.000 114.627 1.00 44.42  ? 171 ALA A CA  1 
ATOM   1104 C C   . ALA A 1 171 ? 138.387 117.921 115.537 1.00 44.42  ? 171 ALA A C   1 
ATOM   1105 O O   . ALA A 1 171 ? 138.387 118.478 116.643 1.00 44.42  ? 171 ALA A O   1 
ATOM   1106 C CB  . ALA A 1 171 ? 139.415 119.091 113.574 1.00 44.42  ? 171 ALA A CB  1 
ATOM   1107 N N   . LEU A 1 172 ? 137.338 117.230 115.090 1.00 44.02  ? 172 LEU A N   1 
ATOM   1108 C CA  . LEU A 1 172 ? 136.159 117.066 115.935 1.00 44.02  ? 172 LEU A CA  1 
ATOM   1109 C C   . LEU A 1 172 ? 136.488 116.259 117.187 1.00 44.02  ? 172 LEU A C   1 
ATOM   1110 O O   . LEU A 1 172 ? 136.036 116.592 118.292 1.00 44.02  ? 172 LEU A O   1 
ATOM   1111 C CB  . LEU A 1 172 ? 135.038 116.410 115.130 1.00 44.02  ? 172 LEU A CB  1 
ATOM   1112 C CG  . LEU A 1 172 ? 133.638 116.286 115.725 1.00 44.02  ? 172 LEU A CG  1 
ATOM   1113 C CD1 . LEU A 1 172 ? 132.642 116.245 114.591 1.00 44.02  ? 172 LEU A CD1 1 
ATOM   1114 C CD2 . LEU A 1 172 ? 133.493 115.050 116.578 1.00 44.02  ? 172 LEU A CD2 1 
ATOM   1115 N N   . LEU A 1 173 ? 137.283 115.196 117.035 1.00 46.35  ? 173 LEU A N   1 
ATOM   1116 C CA  . LEU A 1 173 ? 137.724 114.421 118.191 1.00 46.35  ? 173 LEU A CA  1 
ATOM   1117 C C   . LEU A 1 173 ? 138.576 115.264 119.126 1.00 46.35  ? 173 LEU A C   1 
ATOM   1118 O O   . LEU A 1 173 ? 138.488 115.124 120.348 1.00 46.35  ? 173 LEU A O   1 
ATOM   1119 C CB  . LEU A 1 173 ? 138.497 113.181 117.746 1.00 46.35  ? 173 LEU A CB  1 
ATOM   1120 C CG  . LEU A 1 173 ? 137.737 112.103 116.981 1.00 46.35  ? 173 LEU A CG  1 
ATOM   1121 C CD1 . LEU A 1 173 ? 138.701 111.030 116.509 1.00 46.35  ? 173 LEU A CD1 1 
ATOM   1122 C CD2 . LEU A 1 173 ? 136.646 111.505 117.850 1.00 46.35  ? 173 LEU A CD2 1 
ATOM   1123 N N   . MET A 1 174 ? 139.429 116.124 118.568 1.00 48.30  ? 174 MET A N   1 
ATOM   1124 C CA  . MET A 1 174 ? 140.244 117.006 119.392 1.00 48.30  ? 174 MET A CA  1 
ATOM   1125 C C   . MET A 1 174 ? 139.374 117.957 120.200 1.00 48.30  ? 174 MET A C   1 
ATOM   1126 O O   . MET A 1 174 ? 139.636 118.194 121.383 1.00 48.30  ? 174 MET A O   1 
ATOM   1127 C CB  . MET A 1 174 ? 141.221 117.788 118.509 1.00 48.30  ? 174 MET A CB  1 
ATOM   1128 C CG  . MET A 1 174 ? 142.637 117.207 118.395 1.00 48.30  ? 174 MET A CG  1 
ATOM   1129 S SD  . MET A 1 174 ? 143.485 116.619 119.885 1.00 48.30  ? 174 MET A SD  1 
ATOM   1130 C CE  . MET A 1 174 ? 143.039 117.842 121.121 1.00 48.30  ? 174 MET A CE  1 
ATOM   1131 N N   . ALA A 1 175 ? 138.331 118.512 119.579 1.00 46.51  ? 175 ALA A N   1 
ATOM   1132 C CA  . ALA A 1 175 ? 137.419 119.379 120.321 1.00 46.51  ? 175 ALA A CA  1 
ATOM   1133 C C   . ALA A 1 175 ? 136.710 118.613 121.432 1.00 46.51  ? 175 ALA A C   1 
ATOM   1134 O O   . ALA A 1 175 ? 136.610 119.095 122.571 1.00 46.51  ? 175 ALA A O   1 
ATOM   1135 C CB  . ALA A 1 175 ? 136.402 120.009 119.371 1.00 46.51  ? 175 ALA A CB  1 
ATOM   1136 N N   . ASP A 1 176 ? 136.233 117.405 121.125 1.00 47.25  ? 176 ASP A N   1 
ATOM   1137 C CA  . ASP A 1 176 ? 135.552 116.608 122.139 1.00 47.25  ? 176 ASP A CA  1 
ATOM   1138 C C   . ASP A 1 176 ? 136.486 116.254 123.290 1.00 47.25  ? 176 ASP A C   1 
ATOM   1139 O O   . ASP A 1 176 ? 136.092 116.311 124.460 1.00 47.25  ? 176 ASP A O   1 
ATOM   1140 C CB  . ASP A 1 176 ? 134.964 115.347 121.508 1.00 47.25  ? 176 ASP A CB  1 
ATOM   1141 C CG  . ASP A 1 176 ? 133.572 115.575 120.945 1.00 47.25  ? 176 ASP A CG  1 
ATOM   1142 O OD1 . ASP A 1 176 ? 132.777 116.287 121.594 1.00 47.25  ? 176 ASP A OD1 1 
ATOM   1143 O OD2 . ASP A 1 176 ? 133.274 115.049 119.852 1.00 47.25  ? 176 ASP A OD2 1 
ATOM   1144 N N   . VAL A 1 177 ? 137.735 115.905 122.985 1.00 46.38  ? 177 VAL A N   1 
ATOM   1145 C CA  . VAL A 1 177 ? 138.642 115.500 124.051 1.00 46.38  ? 177 VAL A CA  1 
ATOM   1146 C C   . VAL A 1 177 ? 139.129 116.716 124.832 1.00 46.38  ? 177 VAL A C   1 
ATOM   1147 O O   . VAL A 1 177 ? 139.455 116.601 126.014 1.00 46.38  ? 177 VAL A O   1 
ATOM   1148 C CB  . VAL A 1 177 ? 139.808 114.658 123.501 1.00 46.38  ? 177 VAL A CB  1 
ATOM   1149 C CG1 . VAL A 1 177 ? 140.698 115.471 122.578 1.00 46.38  ? 177 VAL A CG1 1 
ATOM   1150 C CG2 . VAL A 1 177 ? 140.597 114.013 124.635 1.00 46.38  ? 177 VAL A CG2 1 
ATOM   1151 N N   . ILE A 1 178 ? 139.171 117.897 124.211 1.00 45.70  ? 178 ILE A N   1 
ATOM   1152 C CA  . ILE A 1 178 ? 139.438 119.117 124.970 1.00 45.70  ? 178 ILE A CA  1 
ATOM   1153 C C   . ILE A 1 178 ? 138.312 119.377 125.960 1.00 45.70  ? 178 ILE A C   1 
ATOM   1154 O O   . ILE A 1 178 ? 138.552 119.739 127.121 1.00 45.70  ? 178 ILE A O   1 
ATOM   1155 C CB  . ILE A 1 178 ? 139.645 120.308 124.018 1.00 45.70  ? 178 ILE A CB  1 
ATOM   1156 C CG1 . ILE A 1 178 ? 141.079 120.316 123.491 1.00 45.70  ? 178 ILE A CG1 1 
ATOM   1157 C CG2 . ILE A 1 178 ? 139.351 121.614 124.726 1.00 45.70  ? 178 ILE A CG2 1 
ATOM   1158 C CD1 . ILE A 1 178 ? 141.281 121.196 122.285 1.00 45.70  ? 178 ILE A CD1 1 
ATOM   1159 N N   . LEU A 1 179 ? 137.065 119.189 125.523 1.00 46.07  ? 179 LEU A N   1 
ATOM   1160 C CA  . LEU A 1 179 ? 135.945 119.313 126.453 1.00 46.07  ? 179 LEU A CA  1 
ATOM   1161 C C   . LEU A 1 179 ? 136.058 118.294 127.579 1.00 46.07  ? 179 LEU A C   1 
ATOM   1162 O O   . LEU A 1 179 ? 135.768 118.600 128.742 1.00 46.07  ? 179 LEU A O   1 
ATOM   1163 C CB  . LEU A 1 179 ? 134.620 119.152 125.714 1.00 46.07  ? 179 LEU A CB  1 
ATOM   1164 C CG  . LEU A 1 179 ? 134.163 120.352 124.883 1.00 46.07  ? 179 LEU A CG  1 
ATOM   1165 C CD1 . LEU A 1 179 ? 132.965 119.984 124.022 1.00 46.07  ? 179 LEU A CD1 1 
ATOM   1166 C CD2 . LEU A 1 179 ? 133.850 121.545 125.772 1.00 46.07  ? 179 LEU A CD2 1 
ATOM   1167 N N   . LEU A 1 180 ? 136.475 117.072 127.247 1.00 45.63  ? 180 LEU A N   1 
ATOM   1168 C CA  . LEU A 1 180 ? 136.638 116.035 128.259 1.00 45.63  ? 180 LEU A CA  1 
ATOM   1169 C C   . LEU A 1 180 ? 137.738 116.386 129.257 1.00 45.63  ? 180 LEU A C   1 
ATOM   1170 O O   . LEU A 1 180 ? 137.558 116.199 130.467 1.00 45.63  ? 180 LEU A O   1 
ATOM   1171 C CB  . LEU A 1 180 ? 136.919 114.691 127.591 1.00 45.63  ? 180 LEU A CB  1 
ATOM   1172 C CG  . LEU A 1 180 ? 135.715 113.774 127.360 1.00 45.63  ? 180 LEU A CG  1 
ATOM   1173 C CD1 . LEU A 1 180 ? 135.166 113.269 128.683 1.00 45.63  ? 180 LEU A CD1 1 
ATOM   1174 C CD2 . LEU A 1 180 ? 134.620 114.463 126.561 1.00 45.63  ? 180 LEU A CD2 1 
ATOM   1175 N N   . MET A 1 181 ? 138.890 116.880 128.782 1.00 46.61  ? 181 MET A N   1 
ATOM   1176 C CA  . MET A 1 181 ? 139.933 117.288 129.721 1.00 46.61  ? 181 MET A CA  1 
ATOM   1177 C C   . MET A 1 181 ? 139.446 118.416 130.613 1.00 46.61  ? 181 MET A C   1 
ATOM   1178 O O   . MET A 1 181 ? 139.722 118.421 131.817 1.00 46.61  ? 181 MET A O   1 
ATOM   1179 C CB  . MET A 1 181 ? 141.227 117.738 129.029 1.00 46.61  ? 181 MET A CB  1 
ATOM   1180 C CG  . MET A 1 181 ? 142.119 116.674 128.390 1.00 46.61  ? 181 MET A CG  1 
ATOM   1181 S SD  . MET A 1 181 ? 143.182 117.364 127.088 1.00 46.61  ? 181 MET A SD  1 
ATOM   1182 C CE  . MET A 1 181 ? 142.431 116.841 125.565 1.00 46.61  ? 181 MET A CE  1 
ATOM   1183 N N   . THR A 1 182 ? 138.734 119.390 130.042 1.00 45.44  ? 182 THR A N   1 
ATOM   1184 C CA  . THR A 1 182 ? 138.226 120.494 130.852 1.00 45.44  ? 182 THR A CA  1 
ATOM   1185 C C   . THR A 1 182 ? 137.275 119.989 131.930 1.00 45.44  ? 182 THR A C   1 
ATOM   1186 O O   . THR A 1 182 ? 137.387 120.370 133.101 1.00 45.44  ? 182 THR A O   1 
ATOM   1187 C CB  . THR A 1 182 ? 137.528 121.522 129.961 1.00 45.44  ? 182 THR A CB  1 
ATOM   1188 O OG1 . THR A 1 182 ? 138.468 122.061 129.024 1.00 45.44  ? 182 THR A OG1 1 
ATOM   1189 C CG2 . THR A 1 182 ? 136.957 122.656 130.801 1.00 45.44  ? 182 THR A CG2 1 
ATOM   1190 N N   . TRP A 1 183 ? 136.358 119.092 131.557 1.00 44.94  ? 183 TRP A N   1 
ATOM   1191 C CA  . TRP A 1 183 ? 135.407 118.561 132.528 1.00 44.94  ? 183 TRP A CA  1 
ATOM   1192 C C   . TRP A 1 183 ? 136.106 117.768 133.621 1.00 44.94  ? 183 TRP A C   1 
ATOM   1193 O O   . TRP A 1 183 ? 135.780 117.913 134.804 1.00 44.94  ? 183 TRP A O   1 
ATOM   1194 C CB  . TRP A 1 183 ? 134.367 117.693 131.824 1.00 44.94  ? 183 TRP A CB  1 
ATOM   1195 C CG  . TRP A 1 183 ? 133.578 116.835 132.761 1.00 44.94  ? 183 TRP A CG  1 
ATOM   1196 C CD1 . TRP A 1 183 ? 132.983 117.225 133.923 1.00 44.94  ? 183 TRP A CD1 1 
ATOM   1197 C CD2 . TRP A 1 183 ? 133.287 115.443 132.611 1.00 44.94  ? 183 TRP A CD2 1 
ATOM   1198 N NE1 . TRP A 1 183 ? 132.347 116.161 134.509 1.00 44.94  ? 183 TRP A NE1 1 
ATOM   1199 C CE2 . TRP A 1 183 ? 132.521 115.054 133.722 1.00 44.94  ? 183 TRP A CE2 1 
ATOM   1200 C CE3 . TRP A 1 183 ? 133.609 114.486 131.648 1.00 44.94  ? 183 TRP A CE3 1 
ATOM   1201 C CZ2 . TRP A 1 183 ? 132.067 113.753 133.893 1.00 44.94  ? 183 TRP A CZ2 1 
ATOM   1202 C CZ3 . TRP A 1 183 ? 133.159 113.196 131.822 1.00 44.94  ? 183 TRP A CZ3 1 
ATOM   1203 C CH2 . TRP A 1 183 ? 132.398 112.840 132.935 1.00 44.94  ? 183 TRP A CH2 1 
ATOM   1204 N N   . VAL A 1 184 ? 137.074 116.930 133.249 1.00 46.31  ? 184 VAL A N   1 
ATOM   1205 C CA  . VAL A 1 184 ? 137.735 116.085 134.238 1.00 46.31  ? 184 VAL A CA  1 
ATOM   1206 C C   . VAL A 1 184 ? 138.594 116.924 135.177 1.00 46.31  ? 184 VAL A C   1 
ATOM   1207 O O   . VAL A 1 184 ? 138.563 116.745 136.400 1.00 46.31  ? 184 VAL A O   1 
ATOM   1208 C CB  . VAL A 1 184 ? 138.558 114.988 133.544 1.00 46.31  ? 184 VAL A CB  1 
ATOM   1209 C CG1 . VAL A 1 184 ? 139.465 114.297 134.542 1.00 46.31  ? 184 VAL A CG1 1 
ATOM   1210 C CG2 . VAL A 1 184 ? 137.634 113.984 132.882 1.00 46.31  ? 184 VAL A CG2 1 
ATOM   1211 N N   . LEU A 1 185 ? 139.371 117.856 134.625 1.00 47.28  ? 185 LEU A N   1 
ATOM   1212 C CA  . LEU A 1 185 ? 140.339 118.606 135.411 1.00 47.28  ? 185 LEU A CA  1 
ATOM   1213 C C   . LEU A 1 185 ? 139.749 119.828 136.099 1.00 47.28  ? 185 LEU A C   1 
ATOM   1214 O O   . LEU A 1 185 ? 140.439 120.443 136.919 1.00 47.28  ? 185 LEU A O   1 
ATOM   1215 C CB  . LEU A 1 185 ? 141.506 119.042 134.522 1.00 47.28  ? 185 LEU A CB  1 
ATOM   1216 C CG  . LEU A 1 185 ? 142.302 117.915 133.866 1.00 47.28  ? 185 LEU A CG  1 
ATOM   1217 C CD1 . LEU A 1 185 ? 142.960 118.398 132.584 1.00 47.28  ? 185 LEU A CD1 1 
ATOM   1218 C CD2 . LEU A 1 185 ? 143.338 117.360 134.830 1.00 47.28  ? 185 LEU A CD2 1 
ATOM   1219 N N   . THR A 1 186 ? 138.504 120.198 135.802 1.00 48.48  ? 186 THR A N   1 
ATOM   1220 C CA  . THR A 1 186 ? 137.869 121.306 136.500 1.00 48.48  ? 186 THR A CA  1 
ATOM   1221 C C   . THR A 1 186 ? 136.765 120.878 137.451 1.00 48.48  ? 186 THR A C   1 
ATOM   1222 O O   . THR A 1 186 ? 136.510 121.581 138.431 1.00 48.48  ? 186 THR A O   1 
ATOM   1223 C CB  . THR A 1 186 ? 137.293 122.313 135.499 1.00 48.48  ? 186 THR A CB  1 
ATOM   1224 O OG1 . THR A 1 186 ? 138.349 122.844 134.691 1.00 48.48  ? 186 THR A OG1 1 
ATOM   1225 C CG2 . THR A 1 186 ? 136.597 123.448 136.231 1.00 48.48  ? 186 THR A CG2 1 
ATOM   1226 N N   . ASP A 1 187 ? 136.107 119.747 137.194 1.00 50.78  ? 187 ASP A N   1 
ATOM   1227 C CA  . ASP A 1 187 ? 135.051 119.278 138.082 1.00 50.78  ? 187 ASP A CA  1 
ATOM   1228 C C   . ASP A 1 187 ? 134.801 117.789 137.874 1.00 50.78  ? 187 ASP A C   1 
ATOM   1229 O O   . ASP A 1 187 ? 133.951 117.408 137.059 1.00 50.78  ? 187 ASP A O   1 
ATOM   1230 C CB  . ASP A 1 187 ? 133.773 120.084 137.848 1.00 50.78  ? 187 ASP A CB  1 
ATOM   1231 C CG  . ASP A 1 187 ? 132.937 120.215 139.095 1.00 50.78  ? 187 ASP A CG  1 
ATOM   1232 O OD1 . ASP A 1 187 ? 133.166 119.446 140.051 1.00 50.78  ? 187 ASP A OD1 1 
ATOM   1233 O OD2 . ASP A 1 187 ? 132.073 121.113 139.135 1.00 50.78  ? 187 ASP A OD2 1 
ATOM   1234 N N   . PRO A 1 188 ? 135.514 116.922 138.581 1.00 54.37  ? 188 PRO A N   1 
ATOM   1235 C CA  . PRO A 1 188 ? 135.347 115.477 138.404 1.00 54.37  ? 188 PRO A CA  1 
ATOM   1236 C C   . PRO A 1 188 ? 134.085 114.978 139.102 1.00 54.37  ? 188 PRO A C   1 
ATOM   1237 O O   . PRO A 1 188 ? 133.382 115.722 139.782 1.00 54.37  ? 188 PRO A O   1 
ATOM   1238 C CB  . PRO A 1 188 ? 136.610 114.903 139.048 1.00 54.37  ? 188 PRO A CB  1 
ATOM   1239 C CG  . PRO A 1 188 ? 136.970 115.896 140.096 1.00 54.37  ? 188 PRO A CG  1 
ATOM   1240 C CD  . PRO A 1 188 ? 136.539 117.246 139.587 1.00 54.37  ? 188 PRO A CD  1 
ATOM   1241 N N   . ILE A 1 189 ? 133.817 113.684 138.931 1.00 56.58  ? 189 ILE A N   1 
ATOM   1242 C CA  . ILE A 1 189 ? 132.592 113.064 139.443 1.00 56.58  ? 189 ILE A CA  1 
ATOM   1243 C C   . ILE A 1 189 ? 132.878 112.626 140.875 1.00 56.58  ? 189 ILE A C   1 
ATOM   1244 O O   . ILE A 1 189 ? 133.266 111.489 141.135 1.00 56.58  ? 189 ILE A O   1 
ATOM   1245 C CB  . ILE A 1 189 ? 132.130 111.904 138.569 1.00 56.58  ? 189 ILE A CB  1 
ATOM   1246 C CG1 . ILE A 1 189 ? 132.063 112.332 137.107 1.00 56.58  ? 189 ILE A CG1 1 
ATOM   1247 C CG2 . ILE A 1 189 ? 130.774 111.397 139.033 1.00 56.58  ? 189 ILE A CG2 1 
ATOM   1248 C CD1 . ILE A 1 189 ? 132.052 111.171 136.149 1.00 56.58  ? 189 ILE A CD1 1 
ATOM   1249 N N   . GLN A 1 190 ? 132.670 113.540 141.817 1.00 64.94  ? 190 GLN A N   1 
ATOM   1250 C CA  . GLN A 1 190 ? 132.880 113.234 143.227 1.00 64.94  ? 190 GLN A CA  1 
ATOM   1251 C C   . GLN A 1 190 ? 131.813 112.261 143.716 1.00 64.94  ? 190 GLN A C   1 
ATOM   1252 O O   . GLN A 1 190 ? 130.623 112.589 143.729 1.00 64.94  ? 190 GLN A O   1 
ATOM   1253 C CB  . GLN A 1 190 ? 132.851 114.517 144.053 1.00 64.94  ? 190 GLN A CB  1 
ATOM   1254 C CG  . GLN A 1 190 ? 134.185 115.226 144.150 1.00 64.94  ? 190 GLN A CG  1 
ATOM   1255 C CD  . GLN A 1 190 ? 134.036 116.731 144.159 1.00 64.94  ? 190 GLN A CD  1 
ATOM   1256 O OE1 . GLN A 1 190 ? 132.923 117.256 144.150 1.00 64.94  ? 190 GLN A OE1 1 
ATOM   1257 N NE2 . GLN A 1 190 ? 135.161 117.438 144.178 1.00 64.94  ? 190 GLN A NE2 1 
ATOM   1258 N N   . CYS A 1 191 ? 132.238 111.068 144.125 1.00 73.20  ? 191 CYS A N   1 
ATOM   1259 C CA  . CYS A 1 191 ? 131.330 110.055 144.660 1.00 73.20  ? 191 CYS A CA  1 
ATOM   1260 C C   . CYS A 1 191 ? 131.131 110.321 146.143 1.00 73.20  ? 191 CYS A C   1 
ATOM   1261 O O   . CYS A 1 191 ? 131.962 109.947 146.974 1.00 73.20  ? 191 CYS A O   1 
ATOM   1262 C CB  . CYS A 1 191 ? 131.866 108.650 144.411 1.00 73.20  ? 191 CYS A CB  1 
ATOM   1263 S SG  . CYS A 1 191 ? 131.531 108.026 142.755 1.00 73.20  ? 191 CYS A SG  1 
ATOM   1264 N N   . LEU A 1 192 ? 130.022 110.969 146.478 1.00 82.48  ? 192 LEU A N   1 
ATOM   1265 C CA  . LEU A 1 192 ? 129.732 111.365 147.843 1.00 82.48  ? 192 LEU A CA  1 
ATOM   1266 C C   . LEU A 1 192 ? 128.316 110.956 148.216 1.00 82.48  ? 192 LEU A C   1 
ATOM   1267 O O   . LEU A 1 192 ? 127.429 110.871 147.363 1.00 82.48  ? 192 LEU A O   1 
ATOM   1268 C CB  . LEU A 1 192 ? 129.937 112.882 148.022 1.00 82.48  ? 192 LEU A CB  1 
ATOM   1269 C CG  . LEU A 1 192 ? 129.169 113.846 147.107 1.00 82.48  ? 192 LEU A CG  1 
ATOM   1270 C CD1 . LEU A 1 192 ? 127.768 114.159 147.610 1.00 82.48  ? 192 LEU A CD1 1 
ATOM   1271 C CD2 . LEU A 1 192 ? 129.965 115.130 146.908 1.00 82.48  ? 192 LEU A CD2 1 
ATOM   1272 N N   . GLN A 1 193 ? 128.120 110.696 149.506 1.00 94.62  ? 193 GLN A N   1 
ATOM   1273 C CA  . GLN A 1 193 ? 126.820 110.361 150.069 1.00 94.62  ? 193 GLN A CA  1 
ATOM   1274 C C   . GLN A 1 193 ? 126.455 111.412 151.105 1.00 94.62  ? 193 GLN A C   1 
ATOM   1275 O O   . GLN A 1 193 ? 127.276 111.752 151.963 1.00 94.62  ? 193 GLN A O   1 
ATOM   1276 C CB  . GLN A 1 193 ? 126.830 108.969 150.704 1.00 94.62  ? 193 GLN A CB  1 
ATOM   1277 C CG  . GLN A 1 193 ? 125.542 108.610 151.425 1.00 94.62  ? 193 GLN A CG  1 
ATOM   1278 C CD  . GLN A 1 193 ? 125.640 107.296 152.173 1.00 94.62  ? 193 GLN A CD  1 
ATOM   1279 O OE1 . GLN A 1 193 ? 126.667 106.618 152.130 1.00 94.62  ? 193 GLN A OE1 1 
ATOM   1280 N NE2 . GLN A 1 193 ? 124.568 106.928 152.866 1.00 94.62  ? 193 GLN A NE2 1 
ATOM   1281 N N   . ILE A 1 194 ? 125.231 111.923 151.025 1.00 98.31  ? 194 ILE A N   1 
ATOM   1282 C CA  . ILE A 1 194 ? 124.770 112.989 151.902 1.00 98.31  ? 194 ILE A CA  1 
ATOM   1283 C C   . ILE A 1 194 ? 123.464 112.582 152.566 1.00 98.31  ? 194 ILE A C   1 
ATOM   1284 O O   . ILE A 1 194 ? 122.583 111.991 151.932 1.00 98.31  ? 194 ILE A O   1 
ATOM   1285 C CB  . ILE A 1 194 ? 124.598 114.324 151.144 1.00 98.31  ? 194 ILE A CB  1 
ATOM   1286 C CG1 . ILE A 1 194 ? 123.542 114.198 150.043 1.00 98.31  ? 194 ILE A CG1 1 
ATOM   1287 C CG2 . ILE A 1 194 ? 125.925 114.802 150.585 1.00 98.31  ? 194 ILE A CG2 1 
ATOM   1288 C CD1 . ILE A 1 194 ? 123.155 115.519 149.415 1.00 98.31  ? 194 ILE A CD1 1 
ATOM   1289 N N   . LEU A 1 195 ? 123.358 112.879 153.858 1.00 105.29 ? 195 LEU A N   1 
ATOM   1290 C CA  . LEU A 1 195 ? 122.127 112.733 154.619 1.00 105.29 ? 195 LEU A CA  1 
ATOM   1291 C C   . LEU A 1 195 ? 121.738 114.125 155.089 1.00 105.29 ? 195 LEU A C   1 
ATOM   1292 O O   . LEU A 1 195 ? 122.587 114.875 155.583 1.00 105.29 ? 195 LEU A O   1 
ATOM   1293 C CB  . LEU A 1 195 ? 122.301 111.762 155.795 1.00 105.29 ? 195 LEU A CB  1 
ATOM   1294 C CG  . LEU A 1 195 ? 123.342 112.034 156.888 1.00 105.29 ? 195 LEU A CG  1 
ATOM   1295 C CD1 . LEU A 1 195 ? 122.767 112.858 158.036 1.00 105.29 ? 195 LEU A CD1 1 
ATOM   1296 C CD2 . LEU A 1 195 ? 123.929 110.727 157.406 1.00 105.29 ? 195 LEU A CD2 1 
ATOM   1297 N N   . SER A 1 196 ? 120.470 114.480 154.916 1.00 109.65 ? 196 SER A N   1 
ATOM   1298 C CA  . SER A 1 196 ? 120.063 115.855 155.168 1.00 109.65 ? 196 SER A CA  1 
ATOM   1299 C C   . SER A 1 196 ? 118.567 115.921 155.410 1.00 109.65 ? 196 SER A C   1 
ATOM   1300 O O   . SER A 1 196 ? 117.784 115.349 154.647 1.00 109.65 ? 196 SER A O   1 
ATOM   1301 C CB  . SER A 1 196 ? 120.443 116.757 153.988 1.00 109.65 ? 196 SER A CB  1 
ATOM   1302 O OG  . SER A 1 196 ? 119.445 116.728 152.983 1.00 109.65 ? 196 SER A OG  1 
ATOM   1303 N N   . VAL A 1 197 ? 118.179 116.627 156.459 1.00 113.73 ? 197 VAL A N   1 
ATOM   1304 C CA  . VAL A 1 197 ? 116.775 116.884 156.733 1.00 113.73 ? 197 VAL A CA  1 
ATOM   1305 C C   . VAL A 1 197 ? 116.398 118.208 156.084 1.00 113.73 ? 197 VAL A C   1 
ATOM   1306 O O   . VAL A 1 197 ? 117.092 119.218 156.253 1.00 113.73 ? 197 VAL A O   1 
ATOM   1307 C CB  . VAL A 1 197 ? 116.497 116.885 158.246 1.00 113.73 ? 197 VAL A CB  1 
ATOM   1308 C CG1 . VAL A 1 197 ? 116.716 115.490 158.812 1.00 113.73 ? 197 VAL A CG1 1 
ATOM   1309 C CG2 . VAL A 1 197 ? 117.392 117.884 158.968 1.00 113.73 ? 197 VAL A CG2 1 
ATOM   1310 N N   . SER A 1 198 ? 115.321 118.195 155.305 1.00 114.39 ? 198 SER A N   1 
ATOM   1311 C CA  . SER A 1 198 ? 114.894 119.347 154.524 1.00 114.39 ? 198 SER A CA  1 
ATOM   1312 C C   . SER A 1 198 ? 113.493 119.742 154.958 1.00 114.39 ? 198 SER A C   1 
ATOM   1313 O O   . SER A 1 198 ? 112.599 118.892 155.035 1.00 114.39 ? 198 SER A O   1 
ATOM   1314 C CB  . SER A 1 198 ? 114.924 119.045 153.024 1.00 114.39 ? 198 SER A CB  1 
ATOM   1315 O OG  . SER A 1 198 ? 116.217 118.636 152.613 1.00 114.39 ? 198 SER A OG  1 
ATOM   1316 N N   . MET A 1 199 ? 113.305 121.026 155.236 1.00 114.25 ? 199 MET A N   1 
ATOM   1317 C CA  . MET A 1 199 ? 112.038 121.552 155.729 1.00 114.25 ? 199 MET A CA  1 
ATOM   1318 C C   . MET A 1 199 ? 111.405 122.368 154.609 1.00 114.25 ? 199 MET A C   1 
ATOM   1319 O O   . MET A 1 199 ? 111.572 123.586 154.534 1.00 114.25 ? 199 MET A O   1 
ATOM   1320 C CB  . MET A 1 199 ? 112.270 122.378 156.978 1.00 114.25 ? 199 MET A CB  1 
ATOM   1321 C CG  . MET A 1 199 ? 112.742 121.527 158.133 1.00 114.25 ? 199 MET A CG  1 
ATOM   1322 S SD  . MET A 1 199 ? 113.060 122.413 159.660 1.00 114.25 ? 199 MET A SD  1 
ATOM   1323 C CE  . MET A 1 199 ? 113.667 121.045 160.632 1.00 114.25 ? 199 MET A CE  1 
ATOM   1324 N N   . THR A 1 200 ? 110.672 121.684 153.737 1.00 110.51 ? 200 THR A N   1 
ATOM   1325 C CA  . THR A 1 200 ? 109.948 122.336 152.653 1.00 110.51 ? 200 THR A CA  1 
ATOM   1326 C C   . THR A 1 200 ? 108.666 122.940 153.208 1.00 110.51 ? 200 THR A C   1 
ATOM   1327 O O   . THR A 1 200 ? 107.789 122.218 153.693 1.00 110.51 ? 200 THR A O   1 
ATOM   1328 C CB  . THR A 1 200 ? 109.644 121.341 151.538 1.00 110.51 ? 200 THR A CB  1 
ATOM   1329 O OG1 . THR A 1 200 ? 110.864 120.958 150.892 1.00 110.51 ? 200 THR A OG1 1 
ATOM   1330 C CG2 . THR A 1 200 ? 108.702 121.960 150.521 1.00 110.51 ? 200 THR A CG2 1 
ATOM   1331 N N   . VAL A 1 201 ? 108.555 124.262 153.141 1.00 110.38 ? 201 VAL A N   1 
ATOM   1332 C CA  . VAL A 1 201 ? 107.394 124.980 153.646 1.00 110.38 ? 201 VAL A CA  1 
ATOM   1333 C C   . VAL A 1 201 ? 106.755 125.742 152.493 1.00 110.38 ? 201 VAL A C   1 
ATOM   1334 O O   . VAL A 1 201 ? 107.451 126.326 151.655 1.00 110.38 ? 201 VAL A O   1 
ATOM   1335 C CB  . VAL A 1 201 ? 107.766 125.924 154.812 1.00 110.38 ? 201 VAL A CB  1 
ATOM   1336 C CG1 . VAL A 1 201 ? 108.575 125.174 155.858 1.00 110.38 ? 201 VAL A CG1 1 
ATOM   1337 C CG2 . VAL A 1 201 ? 108.543 127.137 154.320 1.00 110.38 ? 201 VAL A CG2 1 
ATOM   1338 N N   . THR A 1 202 ? 105.429 125.686 152.423 1.00 118.08 ? 202 THR A N   1 
ATOM   1339 C CA  . THR A 1 202 ? 104.675 126.412 151.414 1.00 118.08 ? 202 THR A CA  1 
ATOM   1340 C C   . THR A 1 202 ? 104.238 127.762 151.982 1.00 118.08 ? 202 THR A C   1 
ATOM   1341 O O   . THR A 1 202 ? 104.702 128.197 153.039 1.00 118.08 ? 202 THR A O   1 
ATOM   1342 C CB  . THR A 1 202 ? 103.478 125.588 150.944 1.00 118.08 ? 202 THR A CB  1 
ATOM   1343 O OG1 . THR A 1 202 ? 102.411 125.712 151.891 1.00 118.08 ? 202 THR A OG1 1 
ATOM   1344 C CG2 . THR A 1 202 ? 103.858 124.120 150.813 1.00 118.08 ? 202 THR A CG2 1 
ATOM   1345 N N   . GLY A 1 203 ? 103.339 128.445 151.271 1.00 120.94 ? 203 GLY A N   1 
ATOM   1346 C CA  . GLY A 1 203 ? 102.812 129.700 151.776 1.00 120.94 ? 203 GLY A CA  1 
ATOM   1347 C C   . GLY A 1 203 ? 102.007 129.537 153.049 1.00 120.94 ? 203 GLY A C   1 
ATOM   1348 O O   . GLY A 1 203 ? 102.016 130.420 153.911 1.00 120.94 ? 203 GLY A O   1 
ATOM   1349 N N   . LYS A 1 204 ? 101.301 128.413 153.188 1.00 120.57 ? 204 LYS A N   1 
ATOM   1350 C CA  . LYS A 1 204 ? 100.476 128.158 154.360 1.00 120.57 ? 204 LYS A CA  1 
ATOM   1351 C C   . LYS A 1 204 ? 100.712 126.799 155.003 1.00 120.57 ? 204 LYS A C   1 
ATOM   1352 O O   . LYS A 1 204 ? 100.222 126.577 156.116 1.00 120.57 ? 204 LYS A O   1 
ATOM   1353 C CB  . LYS A 1 204 ? 98.986  128.281 154.004 1.00 120.57 ? 204 LYS A CB  1 
ATOM   1354 C CG  . LYS A 1 204 ? 98.527  129.706 153.739 1.00 120.57 ? 204 LYS A CG  1 
ATOM   1355 C CD  . LYS A 1 204 ? 97.058  129.752 153.349 1.00 120.57 ? 204 LYS A CD  1 
ATOM   1356 C CE  . LYS A 1 204 ? 96.611  131.174 153.047 1.00 120.57 ? 204 LYS A CE  1 
ATOM   1357 N NZ  . LYS A 1 204 ? 95.189  131.230 152.611 1.00 120.57 ? 204 LYS A NZ  1 
ATOM   1358 N N   . ASP A 1 205 ? 101.436 125.892 154.355 1.00 120.07 ? 205 ASP A N   1 
ATOM   1359 C CA  . ASP A 1 205 ? 101.681 124.556 154.877 1.00 120.07 ? 205 ASP A CA  1 
ATOM   1360 C C   . ASP A 1 205 ? 103.157 124.390 155.213 1.00 120.07 ? 205 ASP A C   1 
ATOM   1361 O O   . ASP A 1 205 ? 104.026 124.926 154.519 1.00 120.07 ? 205 ASP A O   1 
ATOM   1362 C CB  . ASP A 1 205 ? 101.248 123.484 153.871 1.00 120.07 ? 205 ASP A CB  1 
ATOM   1363 C CG  . ASP A 1 205 ? 101.413 122.077 154.410 1.00 120.07 ? 205 ASP A CG  1 
ATOM   1364 O OD1 . ASP A 1 205 ? 101.126 121.859 155.606 1.00 120.07 ? 205 ASP A OD1 1 
ATOM   1365 O OD2 . ASP A 1 205 ? 101.829 121.188 153.638 1.00 120.07 ? 205 ASP A OD2 1 
ATOM   1366 N N   . VAL A 1 206 ? 103.431 123.643 156.279 1.00 117.87 ? 206 VAL A N   1 
ATOM   1367 C CA  . VAL A 1 206 ? 104.787 123.384 156.747 1.00 117.87 ? 206 VAL A CA  1 
ATOM   1368 C C   . VAL A 1 206 ? 105.025 121.880 156.741 1.00 117.87 ? 206 VAL A C   1 
ATOM   1369 O O   . VAL A 1 206 ? 104.144 121.099 157.118 1.00 117.87 ? 206 VAL A O   1 
ATOM   1370 C CB  . VAL A 1 206 ? 105.031 123.989 158.148 1.00 117.87 ? 206 VAL A CB  1 
ATOM   1371 C CG1 . VAL A 1 206 ? 104.140 123.332 159.196 1.00 117.87 ? 206 VAL A CG1 1 
ATOM   1372 C CG2 . VAL A 1 206 ? 106.496 123.863 158.538 1.00 117.87 ? 206 VAL A CG2 1 
ATOM   1373 N N   . SER A 1 207 ? 106.203 121.475 156.275 1.00 113.19 ? 207 SER A N   1 
ATOM   1374 C CA  . SER A 1 207 ? 106.545 120.062 156.215 1.00 113.19 ? 207 SER A CA  1 
ATOM   1375 C C   . SER A 1 207 ? 108.041 119.895 156.431 1.00 113.19 ? 207 SER A C   1 
ATOM   1376 O O   . SER A 1 207 ? 108.836 120.794 156.148 1.00 113.19 ? 207 SER A O   1 
ATOM   1377 C CB  . SER A 1 207 ? 106.128 119.440 154.879 1.00 113.19 ? 207 SER A CB  1 
ATOM   1378 O OG  . SER A 1 207 ? 106.895 119.971 153.812 1.00 113.19 ? 207 SER A OG  1 
ATOM   1379 N N   . CYS A 1 208 ? 108.413 118.722 156.936 1.00 115.82 ? 208 CYS A N   1 
ATOM   1380 C CA  . CYS A 1 208 ? 109.803 118.365 157.170 1.00 115.82 ? 208 CYS A CA  1 
ATOM   1381 C C   . CYS A 1 208 ? 110.058 116.971 156.621 1.00 115.82 ? 208 CYS A C   1 
ATOM   1382 O O   . CYS A 1 208 ? 109.198 116.091 156.714 1.00 115.82 ? 208 CYS A O   1 
ATOM   1383 C CB  . CYS A 1 208 ? 110.154 118.415 158.661 1.00 115.82 ? 208 CYS A CB  1 
ATOM   1384 S SG  . CYS A 1 208 ? 111.882 118.039 159.034 1.00 115.82 ? 208 CYS A SG  1 
ATOM   1385 N N   . THR A 1 209 ? 111.243 116.774 156.054 1.00 114.68 ? 209 THR A N   1 
ATOM   1386 C CA  . THR A 1 209 ? 111.620 115.507 155.449 1.00 114.68 ? 209 THR A CA  1 
ATOM   1387 C C   . THR A 1 209 ? 113.025 115.132 155.892 1.00 114.68 ? 209 THR A C   1 
ATOM   1388 O O   . THR A 1 209 ? 113.833 115.996 156.238 1.00 114.68 ? 209 THR A O   1 
ATOM   1389 C CB  . THR A 1 209 ? 111.557 115.566 153.915 1.00 114.68 ? 209 THR A CB  1 
ATOM   1390 O OG1 . THR A 1 209 ? 112.140 116.792 153.457 1.00 114.68 ? 209 THR A OG1 1 
ATOM   1391 C CG2 . THR A 1 209 ? 110.116 115.483 153.436 1.00 114.68 ? 209 THR A CG2 1 
ATOM   1392 N N   . SER A 1 210 ? 113.308 113.831 155.881 1.00 110.71 ? 210 SER A N   1 
ATOM   1393 C CA  . SER A 1 210 ? 114.619 113.291 156.240 1.00 110.71 ? 210 SER A CA  1 
ATOM   1394 C C   . SER A 1 210 ? 115.150 112.516 155.038 1.00 110.71 ? 210 SER A C   1 
ATOM   1395 O O   . SER A 1 210 ? 115.046 111.289 154.972 1.00 110.71 ? 210 SER A O   1 
ATOM   1396 C CB  . SER A 1 210 ? 114.524 112.413 157.487 1.00 110.71 ? 210 SER A CB  1 
ATOM   1397 O OG  . SER A 1 210 ? 113.754 111.251 157.234 1.00 110.71 ? 210 SER A OG  1 
ATOM   1398 N N   . THR A 1 211 ? 115.722 113.246 154.083 1.00 109.33 ? 211 THR A N   1 
ATOM   1399 C CA  . THR A 1 211 ? 116.206 112.669 152.835 1.00 109.33 ? 211 THR A CA  1 
ATOM   1400 C C   . THR A 1 211 ? 117.683 112.313 152.951 1.00 109.33 ? 211 THR A C   1 
ATOM   1401 O O   . THR A 1 211 ? 118.504 113.153 153.326 1.00 109.33 ? 211 THR A O   1 
ATOM   1402 C CB  . THR A 1 211 ? 115.990 113.641 151.674 1.00 109.33 ? 211 THR A CB  1 
ATOM   1403 O OG1 . THR A 1 211 ? 116.654 114.879 151.956 1.00 109.33 ? 211 THR A OG1 1 
ATOM   1404 C CG2 . THR A 1 211 ? 114.506 113.903 151.469 1.00 109.33 ? 211 THR A CG2 1 
ATOM   1405 N N   . SER A 1 212 ? 118.018 111.069 152.619 1.00 99.90  ? 212 SER A N   1 
ATOM   1406 C CA  . SER A 1 212 ? 119.404 110.608 152.632 1.00 99.90  ? 212 SER A CA  1 
ATOM   1407 C C   . SER A 1 212 ? 119.638 109.797 151.366 1.00 99.90  ? 212 SER A C   1 
ATOM   1408 O O   . SER A 1 212 ? 119.052 108.723 151.197 1.00 99.90  ? 212 SER A O   1 
ATOM   1409 C CB  . SER A 1 212 ? 119.702 109.779 153.880 1.00 99.90  ? 212 SER A CB  1 
ATOM   1410 O OG  . SER A 1 212 ? 121.073 109.426 153.942 1.00 99.90  ? 212 SER A OG  1 
ATOM   1411 N N   . THR A 1 213 ? 120.492 110.308 150.480 1.00 89.72  ? 213 THR A N   1 
ATOM   1412 C CA  . THR A 1 213 ? 120.755 109.680 149.194 1.00 89.72  ? 213 THR A CA  1 
ATOM   1413 C C   . THR A 1 213 ? 122.252 109.606 148.933 1.00 89.72  ? 213 THR A C   1 
ATOM   1414 O O   . THR A 1 213 ? 123.033 110.410 149.449 1.00 89.72  ? 213 THR A O   1 
ATOM   1415 C CB  . THR A 1 213 ? 120.075 110.438 148.045 1.00 89.72  ? 213 THR A CB  1 
ATOM   1416 O OG1 . THR A 1 213 ? 120.440 109.841 146.794 1.00 89.72  ? 213 THR A OG1 1 
ATOM   1417 C CG2 . THR A 1 213 ? 120.496 111.900 148.046 1.00 89.72  ? 213 THR A CG2 1 
ATOM   1418 N N   . HIS A 1 214 ? 122.639 108.622 148.123 1.00 83.49  ? 214 HIS A N   1 
ATOM   1419 C CA  . HIS A 1 214 ? 124.022 108.408 147.708 1.00 83.49  ? 214 HIS A CA  1 
ATOM   1420 C C   . HIS A 1 214 ? 124.062 108.427 146.187 1.00 83.49  ? 214 HIS A C   1 
ATOM   1421 O O   . HIS A 1 214 ? 123.541 107.513 145.538 1.00 83.49  ? 214 HIS A O   1 
ATOM   1422 C CB  . HIS A 1 214 ? 124.570 107.090 148.249 1.00 83.49  ? 214 HIS A CB  1 
ATOM   1423 C CG  . HIS A 1 214 ? 125.782 106.599 147.521 1.00 83.49  ? 214 HIS A CG  1 
ATOM   1424 N ND1 . HIS A 1 214 ? 127.063 106.946 147.891 1.00 83.49  ? 214 HIS A ND1 1 
ATOM   1425 C CD2 . HIS A 1 214 ? 125.908 105.787 146.445 1.00 83.49  ? 214 HIS A CD2 1 
ATOM   1426 C CE1 . HIS A 1 214 ? 127.927 106.370 147.074 1.00 83.49  ? 214 HIS A CE1 1 
ATOM   1427 N NE2 . HIS A 1 214 ? 127.252 105.662 146.187 1.00 83.49  ? 214 HIS A NE2 1 
ATOM   1428 N N   . PHE A 1 215 ? 124.670 109.462 145.617 1.00 73.71  ? 215 PHE A N   1 
ATOM   1429 C CA  . PHE A 1 215 ? 124.802 109.572 144.174 1.00 73.71  ? 215 PHE A CA  1 
ATOM   1430 C C   . PHE A 1 215 ? 126.222 109.971 143.806 1.00 73.71  ? 215 PHE A C   1 
ATOM   1431 O O   . PHE A 1 215 ? 126.834 110.813 144.470 1.00 73.71  ? 215 PHE A O   1 
ATOM   1432 C CB  . PHE A 1 215 ? 123.814 110.597 143.609 1.00 73.71  ? 215 PHE A CB  1 
ATOM   1433 C CG  . PHE A 1 215 ? 123.917 111.956 144.246 1.00 73.71  ? 215 PHE A CG  1 
ATOM   1434 C CD1 . PHE A 1 215 ? 123.257 112.235 145.431 1.00 73.71  ? 215 PHE A CD1 1 
ATOM   1435 C CD2 . PHE A 1 215 ? 124.669 112.958 143.654 1.00 73.71  ? 215 PHE A CD2 1 
ATOM   1436 C CE1 . PHE A 1 215 ? 123.350 113.483 146.017 1.00 73.71  ? 215 PHE A CE1 1 
ATOM   1437 C CE2 . PHE A 1 215 ? 124.766 114.208 144.235 1.00 73.71  ? 215 PHE A CE2 1 
ATOM   1438 C CZ  . PHE A 1 215 ? 124.105 114.471 145.418 1.00 73.71  ? 215 PHE A CZ  1 
ATOM   1439 N N   . CYS A 1 216 ? 126.739 109.355 142.745 1.00 68.80  ? 216 CYS A N   1 
ATOM   1440 C CA  . CYS A 1 216 ? 128.035 109.715 142.173 1.00 68.80  ? 216 CYS A CA  1 
ATOM   1441 C C   . CYS A 1 216 ? 127.786 110.739 141.075 1.00 68.80  ? 216 CYS A C   1 
ATOM   1442 O O   . CYS A 1 216 ? 127.502 110.381 139.930 1.00 68.80  ? 216 CYS A O   1 
ATOM   1443 C CB  . CYS A 1 216 ? 128.749 108.483 141.632 1.00 68.80  ? 216 CYS A CB  1 
ATOM   1444 S SG  . CYS A 1 216 ? 129.222 107.252 142.866 1.00 68.80  ? 216 CYS A SG  1 
ATOM   1445 N N   . ALA A 1 217 ? 127.892 112.018 141.417 1.00 60.20  ? 217 ALA A N   1 
ATOM   1446 C CA  . ALA A 1 217 ? 127.656 113.088 140.462 1.00 60.20  ? 217 ALA A CA  1 
ATOM   1447 C C   . ALA A 1 217 ? 128.640 114.216 140.727 1.00 60.20  ? 217 ALA A C   1 
ATOM   1448 O O   . ALA A 1 217 ? 129.336 114.239 141.746 1.00 60.20  ? 217 ALA A O   1 
ATOM   1449 C CB  . ALA A 1 217 ? 126.215 113.603 140.533 1.00 60.20  ? 217 ALA A CB  1 
ATOM   1450 N N   . SER A 1 218 ? 128.690 115.159 139.795 1.00 52.13  ? 218 SER A N   1 
ATOM   1451 C CA  . SER A 1 218 ? 129.588 116.296 139.881 1.00 52.13  ? 218 SER A CA  1 
ATOM   1452 C C   . SER A 1 218 ? 128.784 117.580 139.997 1.00 52.13  ? 218 SER A C   1 
ATOM   1453 O O   . SER A 1 218 ? 127.668 117.682 139.481 1.00 52.13  ? 218 SER A O   1 
ATOM   1454 C CB  . SER A 1 218 ? 130.502 116.376 138.659 1.00 52.13  ? 218 SER A CB  1 
ATOM   1455 O OG  . SER A 1 218 ? 129.747 116.445 137.465 1.00 52.13  ? 218 SER A OG  1 
ATOM   1456 N N   . ARG A 1 219 ? 129.356 118.559 140.691 1.00 51.76  ? 219 ARG A N   1 
ATOM   1457 C CA  . ARG A 1 219 ? 128.776 119.891 140.686 1.00 51.76  ? 219 ARG A CA  1 
ATOM   1458 C C   . ARG A 1 219 ? 128.843 120.462 139.277 1.00 51.76  ? 219 ARG A C   1 
ATOM   1459 O O   . ARG A 1 219 ? 129.700 120.085 138.473 1.00 51.76  ? 219 ARG A O   1 
ATOM   1460 C CB  . ARG A 1 219 ? 129.508 120.800 141.669 1.00 51.76  ? 219 ARG A CB  1 
ATOM   1461 C CG  . ARG A 1 219 ? 129.363 120.380 143.118 1.00 51.76  ? 219 ARG A CG  1 
ATOM   1462 C CD  . ARG A 1 219 ? 129.945 121.424 144.057 1.00 51.76  ? 219 ARG A CD  1 
ATOM   1463 N NE  . ARG A 1 219 ? 131.214 121.952 143.568 1.00 51.76  ? 219 ARG A NE  1 
ATOM   1464 C CZ  . ARG A 1 219 ? 131.788 123.058 144.021 1.00 51.76  ? 219 ARG A CZ  1 
ATOM   1465 N NH1 . ARG A 1 219 ? 131.233 123.783 144.979 1.00 51.76  ? 219 ARG A NH1 1 
ATOM   1466 N NH2 . ARG A 1 219 ? 132.948 123.447 143.500 1.00 51.76  ? 219 ARG A NH2 1 
ATOM   1467 N N   . TYR A 1 220 ? 127.911 121.360 138.970 1.00 48.64  ? 220 TYR A N   1 
ATOM   1468 C CA  . TYR A 1 220 ? 127.781 121.916 137.623 1.00 48.64  ? 220 TYR A CA  1 
ATOM   1469 C C   . TYR A 1 220 ? 127.610 120.802 136.593 1.00 48.64  ? 220 TYR A C   1 
ATOM   1470 O O   . TYR A 1 220 ? 128.121 120.881 135.476 1.00 48.64  ? 220 TYR A O   1 
ATOM   1471 C CB  . TYR A 1 220 ? 128.974 122.808 137.268 1.00 48.64  ? 220 TYR A CB  1 
ATOM   1472 C CG  . TYR A 1 220 ? 129.263 123.886 138.286 1.00 48.64  ? 220 TYR A CG  1 
ATOM   1473 C CD1 . TYR A 1 220 ? 130.118 123.650 139.352 1.00 48.64  ? 220 TYR A CD1 1 
ATOM   1474 C CD2 . TYR A 1 220 ? 128.681 125.139 138.180 1.00 48.64  ? 220 TYR A CD2 1 
ATOM   1475 C CE1 . TYR A 1 220 ? 130.383 124.629 140.284 1.00 48.64  ? 220 TYR A CE1 1 
ATOM   1476 C CE2 . TYR A 1 220 ? 128.941 126.127 139.107 1.00 48.64  ? 220 TYR A CE2 1 
ATOM   1477 C CZ  . TYR A 1 220 ? 129.793 125.866 140.157 1.00 48.64  ? 220 TYR A CZ  1 
ATOM   1478 O OH  . TYR A 1 220 ? 130.056 126.848 141.085 1.00 48.64  ? 220 TYR A OH  1 
ATOM   1479 N N   . SER A 1 221 ? 126.888 119.748 136.980 1.00 46.47  ? 221 SER A N   1 
ATOM   1480 C CA  . SER A 1 221 ? 126.668 118.628 136.071 1.00 46.47  ? 221 SER A CA  1 
ATOM   1481 C C   . SER A 1 221 ? 125.866 119.058 134.854 1.00 46.47  ? 221 SER A C   1 
ATOM   1482 O O   . SER A 1 221 ? 126.167 118.650 133.725 1.00 46.47  ? 221 SER A O   1 
ATOM   1483 C CB  . SER A 1 221 ? 125.960 117.489 136.801 1.00 46.47  ? 221 SER A CB  1 
ATOM   1484 O OG  . SER A 1 221 ? 124.695 117.902 137.281 1.00 46.47  ? 221 SER A OG  1 
ATOM   1485 N N   . ASP A 1 222 ? 124.837 119.880 135.064 1.00 45.05  ? 222 ASP A N   1 
ATOM   1486 C CA  . ASP A 1 222 ? 124.048 120.363 133.940 1.00 45.05  ? 222 ASP A CA  1 
ATOM   1487 C C   . ASP A 1 222 ? 124.878 121.239 133.013 1.00 45.05  ? 222 ASP A C   1 
ATOM   1488 O O   . ASP A 1 222 ? 124.622 121.266 131.810 1.00 45.05  ? 222 ASP A O   1 
ATOM   1489 C CB  . ASP A 1 222 ? 122.817 121.116 134.441 1.00 45.05  ? 222 ASP A CB  1 
ATOM   1490 C CG  . ASP A 1 222 ? 121.889 120.234 135.253 1.00 45.05  ? 222 ASP A CG  1 
ATOM   1491 O OD1 . ASP A 1 222 ? 121.197 119.385 134.652 1.00 45.05  ? 222 ASP A OD1 1 
ATOM   1492 O OD2 . ASP A 1 222 ? 121.851 120.387 136.493 1.00 45.05  ? 222 ASP A OD2 1 
ATOM   1493 N N   . VAL A 1 223 ? 125.889 121.933 133.541 1.00 43.90  ? 223 VAL A N   1 
ATOM   1494 C CA  . VAL A 1 223 ? 126.785 122.714 132.688 1.00 43.90  ? 223 VAL A CA  1 
ATOM   1495 C C   . VAL A 1 223 ? 127.494 121.807 131.691 1.00 43.90  ? 223 VAL A C   1 
ATOM   1496 O O   . VAL A 1 223 ? 127.508 122.067 130.481 1.00 43.90  ? 223 VAL A O   1 
ATOM   1497 C CB  . VAL A 1 223 ? 127.796 123.497 133.543 1.00 43.90  ? 223 VAL A CB  1 
ATOM   1498 C CG1 . VAL A 1 223 ? 128.800 124.197 132.657 1.00 43.90  ? 223 VAL A CG1 1 
ATOM   1499 C CG2 . VAL A 1 223 ? 127.081 124.490 134.441 1.00 43.90  ? 223 VAL A CG2 1 
ATOM   1500 N N   . TRP A 1 224 ? 128.085 120.718 132.186 1.00 43.23  ? 224 TRP A N   1 
ATOM   1501 C CA  . TRP A 1 224 ? 128.846 119.829 131.318 1.00 43.23  ? 224 TRP A CA  1 
ATOM   1502 C C   . TRP A 1 224 ? 127.933 119.078 130.365 1.00 43.23  ? 224 TRP A C   1 
ATOM   1503 O O   . TRP A 1 224 ? 128.257 118.918 129.179 1.00 43.23  ? 224 TRP A O   1 
ATOM   1504 C CB  . TRP A 1 224 ? 129.668 118.863 132.162 1.00 43.23  ? 224 TRP A CB  1 
ATOM   1505 C CG  . TRP A 1 224 ? 130.596 119.562 133.089 1.00 43.23  ? 224 TRP A CG  1 
ATOM   1506 C CD1 . TRP A 1 224 ? 130.599 119.495 134.445 1.00 43.23  ? 224 TRP A CD1 1 
ATOM   1507 C CD2 . TRP A 1 224 ? 131.664 120.439 132.727 1.00 43.23  ? 224 TRP A CD2 1 
ATOM   1508 N NE1 . TRP A 1 224 ? 131.602 120.277 134.955 1.00 43.23  ? 224 TRP A NE1 1 
ATOM   1509 C CE2 . TRP A 1 224 ? 132.270 120.869 133.918 1.00 43.23  ? 224 TRP A CE2 1 
ATOM   1510 C CE3 . TRP A 1 224 ? 132.165 120.902 131.511 1.00 43.23  ? 224 TRP A CE3 1 
ATOM   1511 C CZ2 . TRP A 1 224 ? 133.349 121.739 133.929 1.00 43.23  ? 224 TRP A CZ2 1 
ATOM   1512 C CZ3 . TRP A 1 224 ? 133.233 121.767 131.524 1.00 43.23  ? 224 TRP A CZ3 1 
ATOM   1513 C CH2 . TRP A 1 224 ? 133.816 122.176 132.725 1.00 43.23  ? 224 TRP A CH2 1 
ATOM   1514 N N   . ILE A 1 225 ? 126.795 118.597 130.868 1.00 43.43  ? 225 ILE A N   1 
ATOM   1515 C CA  . ILE A 1 225 ? 125.827 117.947 129.994 1.00 43.43  ? 225 ILE A CA  1 
ATOM   1516 C C   . ILE A 1 225 ? 125.383 118.909 128.904 1.00 43.43  ? 225 ILE A C   1 
ATOM   1517 O O   . ILE A 1 225 ? 125.324 118.549 127.727 1.00 43.43  ? 225 ILE A O   1 
ATOM   1518 C CB  . ILE A 1 225 ? 124.631 117.419 130.808 1.00 43.43  ? 225 ILE A CB  1 
ATOM   1519 C CG1 . ILE A 1 225 ? 125.086 116.349 131.798 1.00 43.43  ? 225 ILE A CG1 1 
ATOM   1520 C CG2 . ILE A 1 225 ? 123.572 116.858 129.891 1.00 43.43  ? 225 ILE A CG2 1 
ATOM   1521 C CD1 . ILE A 1 225 ? 124.028 115.966 132.807 1.00 43.43  ? 225 ILE A CD1 1 
ATOM   1522 N N   . ALA A 1 226 ? 125.119 120.164 129.262 1.00 41.42  ? 226 ALA A N   1 
ATOM   1523 C CA  . ALA A 1 226 ? 124.650 121.113 128.269 1.00 41.42  ? 226 ALA A CA  1 
ATOM   1524 C C   . ALA A 1 226 ? 125.719 121.392 127.227 1.00 41.42  ? 226 ALA A C   1 
ATOM   1525 O O   . ALA A 1 226 ? 125.415 121.455 126.038 1.00 41.42  ? 226 ALA A O   1 
ATOM   1526 C CB  . ALA A 1 226 ? 124.207 122.406 128.948 1.00 41.42  ? 226 ALA A CB  1 
ATOM   1527 N N   . LEU A 1 227 ? 126.979 121.530 127.639 1.00 41.86  ? 227 LEU A N   1 
ATOM   1528 C CA  . LEU A 1 227 ? 128.028 121.803 126.659 1.00 41.86  ? 227 LEU A CA  1 
ATOM   1529 C C   . LEU A 1 227 ? 128.250 120.623 125.716 1.00 41.86  ? 227 LEU A C   1 
ATOM   1530 O O   . LEU A 1 227 ? 128.284 120.798 124.491 1.00 41.86  ? 227 LEU A O   1 
ATOM   1531 C CB  . LEU A 1 227 ? 129.330 122.175 127.367 1.00 41.86  ? 227 LEU A CB  1 
ATOM   1532 C CG  . LEU A 1 227 ? 129.318 123.483 128.152 1.00 41.86  ? 227 LEU A CG  1 
ATOM   1533 C CD1 . LEU A 1 227 ? 130.618 123.658 128.913 1.00 41.86  ? 227 LEU A CD1 1 
ATOM   1534 C CD2 . LEU A 1 227 ? 129.075 124.658 127.220 1.00 41.86  ? 227 LEU A CD2 1 
ATOM   1535 N N   . ILE A 1 228 ? 128.371 119.408 126.261 1.00 43.99  ? 228 ILE A N   1 
ATOM   1536 C CA  . ILE A 1 228 ? 128.613 118.241 125.409 1.00 43.99  ? 228 ILE A CA  1 
ATOM   1537 C C   . ILE A 1 228 ? 127.429 117.988 124.483 1.00 43.99  ? 228 ILE A C   1 
ATOM   1538 O O   . ILE A 1 228 ? 127.591 117.792 123.270 1.00 43.99  ? 228 ILE A O   1 
ATOM   1539 C CB  . ILE A 1 228 ? 128.929 117.005 126.269 1.00 43.99  ? 228 ILE A CB  1 
ATOM   1540 C CG1 . ILE A 1 228 ? 130.181 117.249 127.113 1.00 43.99  ? 228 ILE A CG1 1 
ATOM   1541 C CG2 . ILE A 1 228 ? 129.112 115.784 125.390 1.00 43.99  ? 228 ILE A CG2 1 
ATOM   1542 C CD1 . ILE A 1 228 ? 131.453 117.334 126.307 1.00 43.99  ? 228 ILE A CD1 1 
ATOM   1543 N N   . TRP A 1 229 ? 126.219 118.011 125.039 1.00 45.11  ? 229 TRP A N   1 
ATOM   1544 C CA  . TRP A 1 229 ? 125.011 117.781 124.261 1.00 45.11  ? 229 TRP A CA  1 
ATOM   1545 C C   . TRP A 1 229 ? 124.750 118.899 123.262 1.00 45.11  ? 229 TRP A C   1 
ATOM   1546 O O   . TRP A 1 229 ? 124.254 118.628 122.171 1.00 45.11  ? 229 TRP A O   1 
ATOM   1547 C CB  . TRP A 1 229 ? 123.850 117.582 125.233 1.00 45.11  ? 229 TRP A CB  1 
ATOM   1548 C CG  . TRP A 1 229 ? 123.974 116.315 126.060 1.00 45.11  ? 229 TRP A CG  1 
ATOM   1549 C CD1 . TRP A 1 229 ? 124.970 115.988 126.937 1.00 45.11  ? 229 TRP A CD1 1 
ATOM   1550 C CD2 . TRP A 1 229 ? 122.970 115.306 126.219 1.00 45.11  ? 229 TRP A CD2 1 
ATOM   1551 N NE1 . TRP A 1 229 ? 124.701 114.789 127.544 1.00 45.11  ? 229 TRP A NE1 1 
ATOM   1552 C CE2 . TRP A 1 229 ? 123.470 114.356 127.132 1.00 45.11  ? 229 TRP A CE2 1 
ATOM   1553 C CE3 . TRP A 1 229 ? 121.714 115.094 125.647 1.00 45.11  ? 229 TRP A CE3 1 
ATOM   1554 C CZ2 . TRP A 1 229 ? 122.759 113.216 127.486 1.00 45.11  ? 229 TRP A CZ2 1 
ATOM   1555 C CZ3 . TRP A 1 229 ? 121.010 113.967 126.003 1.00 45.11  ? 229 TRP A CZ3 1 
ATOM   1556 C CH2 . TRP A 1 229 ? 121.535 113.038 126.910 1.00 45.11  ? 229 TRP A CH2 1 
ATOM   1557 N N   . GLY A 1 230 ? 125.084 120.148 123.591 1.00 43.22  ? 230 GLY A N   1 
ATOM   1558 C CA  . GLY A 1 230 ? 124.923 121.226 122.631 1.00 43.22  ? 230 GLY A CA  1 
ATOM   1559 C C   . GLY A 1 230 ? 125.896 121.130 121.473 1.00 43.22  ? 230 GLY A C   1 
ATOM   1560 O O   . GLY A 1 230 ? 125.529 121.378 120.320 1.00 43.22  ? 230 GLY A O   1 
ATOM   1561 N N   . CYS A 1 231 ? 127.154 120.782 121.759 1.00 45.32  ? 231 CYS A N   1 
ATOM   1562 C CA  . CYS A 1 231 ? 128.116 120.561 120.683 1.00 45.32  ? 231 CYS A CA  1 
ATOM   1563 C C   . CYS A 1 231 ? 127.659 119.423 119.778 1.00 45.32  ? 231 CYS A C   1 
ATOM   1564 O O   . CYS A 1 231 ? 127.643 119.553 118.543 1.00 45.32  ? 231 CYS A O   1 
ATOM   1565 C CB  . CYS A 1 231 ? 129.497 120.272 121.268 1.00 45.32  ? 231 CYS A CB  1 
ATOM   1566 S SG  . CYS A 1 231 ? 130.343 121.725 121.927 1.00 45.32  ? 231 CYS A SG  1 
ATOM   1567 N N   . LYS A 1 232 ? 127.257 118.300 120.379 1.00 43.35  ? 232 LYS A N   1 
ATOM   1568 C CA  . LYS A 1 232 ? 126.751 117.190 119.584 1.00 43.35  ? 232 LYS A CA  1 
ATOM   1569 C C   . LYS A 1 232 ? 125.486 117.577 118.831 1.00 43.35  ? 232 LYS A C   1 
ATOM   1570 O O   . LYS A 1 232 ? 125.265 117.105 117.715 1.00 43.35  ? 232 LYS A O   1 
ATOM   1571 C CB  . LYS A 1 232 ? 126.496 115.977 120.476 1.00 43.35  ? 232 LYS A CB  1 
ATOM   1572 C CG  . LYS A 1 232 ? 126.816 114.649 119.813 1.00 43.35  ? 232 LYS A CG  1 
ATOM   1573 C CD  . LYS A 1 232 ? 128.308 114.497 119.579 1.00 43.35  ? 232 LYS A CD  1 
ATOM   1574 C CE  . LYS A 1 232 ? 129.065 114.389 120.889 1.00 43.35  ? 232 LYS A CE  1 
ATOM   1575 N NZ  . LYS A 1 232 ? 130.535 114.373 120.671 1.00 43.35  ? 232 LYS A NZ  1 
ATOM   1576 N N   . GLY A 1 233 ? 124.654 118.441 119.414 1.00 42.67  ? 233 GLY A N   1 
ATOM   1577 C CA  . GLY A 1 233 ? 123.438 118.862 118.740 1.00 42.67  ? 233 GLY A CA  1 
ATOM   1578 C C   . GLY A 1 233 ? 123.711 119.729 117.530 1.00 42.67  ? 233 GLY A C   1 
ATOM   1579 O O   . GLY A 1 233 ? 123.040 119.601 116.504 1.00 42.67  ? 233 GLY A O   1 
ATOM   1580 N N   . LEU A 1 234 ? 124.682 120.636 117.635 1.00 40.99  ? 234 LEU A N   1 
ATOM   1581 C CA  . LEU A 1 234 ? 125.082 121.410 116.464 1.00 40.99  ? 234 LEU A CA  1 
ATOM   1582 C C   . LEU A 1 234 ? 125.656 120.498 115.389 1.00 40.99  ? 234 LEU A C   1 
ATOM   1583 O O   . LEU A 1 234 ? 125.388 120.681 114.192 1.00 40.99  ? 234 LEU A O   1 
ATOM   1584 C CB  . LEU A 1 234 ? 126.086 122.491 116.860 1.00 40.99  ? 234 LEU A CB  1 
ATOM   1585 C CG  . LEU A 1 234 ? 125.566 123.555 117.830 1.00 40.99  ? 234 LEU A CG  1 
ATOM   1586 C CD1 . LEU A 1 234 ? 126.630 124.603 118.104 1.00 40.99  ? 234 LEU A CD1 1 
ATOM   1587 C CD2 . LEU A 1 234 ? 124.305 124.201 117.291 1.00 40.99  ? 234 LEU A CD2 1 
ATOM   1588 N N   . LEU A 1 235 ? 126.430 119.491 115.803 1.00 39.06  ? 235 LEU A N   1 
ATOM   1589 C CA  . LEU A 1 235 ? 126.925 118.504 114.847 1.00 39.06  ? 235 LEU A CA  1 
ATOM   1590 C C   . LEU A 1 235 ? 125.777 117.778 114.156 1.00 39.06  ? 235 LEU A C   1 
ATOM   1591 O O   . LEU A 1 235 ? 125.800 117.584 112.937 1.00 39.06  ? 235 LEU A O   1 
ATOM   1592 C CB  . LEU A 1 235 ? 127.835 117.503 115.552 1.00 39.06  ? 235 LEU A CB  1 
ATOM   1593 C CG  . LEU A 1 235 ? 128.461 116.463 114.628 1.00 39.06  ? 235 LEU A CG  1 
ATOM   1594 C CD1 . LEU A 1 235 ? 129.355 117.155 113.615 1.00 39.06  ? 235 LEU A CD1 1 
ATOM   1595 C CD2 . LEU A 1 235 ? 129.222 115.415 115.418 1.00 39.06  ? 235 LEU A CD2 1 
ATOM   1596 N N   . LEU A 1 236 ? 124.759 117.374 114.919 1.00 39.25  ? 236 LEU A N   1 
ATOM   1597 C CA  . LEU A 1 236 ? 123.630 116.654 114.339 1.00 39.25  ? 236 LEU A CA  1 
ATOM   1598 C C   . LEU A 1 236 ? 122.796 117.549 113.438 1.00 39.25  ? 236 LEU A C   1 
ATOM   1599 O O   . LEU A 1 236 ? 122.247 117.077 112.439 1.00 39.25  ? 236 LEU A O   1 
ATOM   1600 C CB  . LEU A 1 236 ? 122.752 116.053 115.436 1.00 39.25  ? 236 LEU A CB  1 
ATOM   1601 C CG  . LEU A 1 236 ? 123.392 115.066 116.412 1.00 39.25  ? 236 LEU A CG  1 
ATOM   1602 C CD1 . LEU A 1 236 ? 122.329 114.339 117.214 1.00 39.25  ? 236 LEU A CD1 1 
ATOM   1603 C CD2 . LEU A 1 236 ? 124.276 114.077 115.669 1.00 39.25  ? 236 LEU A CD2 1 
ATOM   1604 N N   . LEU A 1 237 ? 122.670 118.831 113.776 1.00 39.09  ? 237 LEU A N   1 
ATOM   1605 C CA  . LEU A 1 237 ? 121.958 119.754 112.902 1.00 39.09  ? 237 LEU A CA  1 
ATOM   1606 C C   . LEU A 1 237 ? 122.684 119.927 111.577 1.00 39.09  ? 237 LEU A C   1 
ATOM   1607 O O   . LEU A 1 237 ? 122.055 119.915 110.511 1.00 39.09  ? 237 LEU A O   1 
ATOM   1608 C CB  . LEU A 1 237 ? 121.785 121.100 113.591 1.00 39.09  ? 237 LEU A CB  1 
ATOM   1609 C CG  . LEU A 1 237 ? 120.794 121.052 114.741 1.00 39.09  ? 237 LEU A CG  1 
ATOM   1610 C CD1 . LEU A 1 237 ? 120.937 122.279 115.617 1.00 39.09  ? 237 LEU A CD1 1 
ATOM   1611 C CD2 . LEU A 1 237 ? 119.389 120.910 114.197 1.00 39.09  ? 237 LEU A CD2 1 
ATOM   1612 N N   . TYR A 1 238 ? 124.010 120.076 111.617 1.00 39.73  ? 238 TYR A N   1 
ATOM   1613 C CA  . TYR A 1 238 ? 124.750 120.139 110.362 1.00 39.73  ? 238 TYR A CA  1 
ATOM   1614 C C   . TYR A 1 238 ? 124.676 118.822 109.600 1.00 39.73  ? 238 TYR A C   1 
ATOM   1615 O O   . TYR A 1 238 ? 124.656 118.822 108.364 1.00 39.73  ? 238 TYR A O   1 
ATOM   1616 C CB  . TYR A 1 238 ? 126.204 120.525 110.607 1.00 39.73  ? 238 TYR A CB  1 
ATOM   1617 C CG  . TYR A 1 238 ? 126.920 120.910 109.336 1.00 39.73  ? 238 TYR A CG  1 
ATOM   1618 C CD1 . TYR A 1 238 ? 126.460 121.956 108.553 1.00 39.73  ? 238 TYR A CD1 1 
ATOM   1619 C CD2 . TYR A 1 238 ? 128.043 120.219 108.910 1.00 39.73  ? 238 TYR A CD2 1 
ATOM   1620 C CE1 . TYR A 1 238 ? 127.101 122.311 107.387 1.00 39.73  ? 238 TYR A CE1 1 
ATOM   1621 C CE2 . TYR A 1 238 ? 128.692 120.567 107.743 1.00 39.73  ? 238 TYR A CE2 1 
ATOM   1622 C CZ  . TYR A 1 238 ? 128.216 121.614 106.986 1.00 39.73  ? 238 TYR A CZ  1 
ATOM   1623 O OH  . TYR A 1 238 ? 128.857 121.968 105.822 1.00 39.73  ? 238 TYR A OH  1 
ATOM   1624 N N   . GLY A 1 239 ? 124.622 117.696 110.309 1.00 36.08  ? 239 GLY A N   1 
ATOM   1625 C CA  . GLY A 1 239 ? 124.474 116.420 109.633 1.00 36.08  ? 239 GLY A CA  1 
ATOM   1626 C C   . GLY A 1 239 ? 123.127 116.272 108.955 1.00 36.08  ? 239 GLY A C   1 
ATOM   1627 O O   . GLY A 1 239 ? 123.033 115.725 107.855 1.00 36.08  ? 239 GLY A O   1 
ATOM   1628 N N   . ALA A 1 240 ? 122.067 116.748 109.604 1.00 37.22  ? 240 ALA A N   1 
ATOM   1629 C CA  . ALA A 1 240 ? 120.753 116.763 108.973 1.00 37.22  ? 240 ALA A CA  1 
ATOM   1630 C C   . ALA A 1 240 ? 120.738 117.689 107.766 1.00 37.22  ? 240 ALA A C   1 
ATOM   1631 O O   . ALA A 1 240 ? 120.124 117.376 106.741 1.00 37.22  ? 240 ALA A O   1 
ATOM   1632 C CB  . ALA A 1 240 ? 119.690 117.180 109.985 1.00 37.22  ? 240 ALA A CB  1 
ATOM   1633 N N   . TYR A 1 241 ? 121.416 118.834 107.867 1.00 37.72  ? 241 TYR A N   1 
ATOM   1634 C CA  . TYR A 1 241 ? 121.527 119.732 106.722 1.00 37.72  ? 241 TYR A CA  1 
ATOM   1635 C C   . TYR A 1 241 ? 122.240 119.057 105.557 1.00 37.72  ? 241 TYR A C   1 
ATOM   1636 O O   . TYR A 1 241 ? 121.809 119.171 104.403 1.00 37.72  ? 241 TYR A O   1 
ATOM   1637 C CB  . TYR A 1 241 ? 122.254 121.006 107.149 1.00 37.72  ? 241 TYR A CB  1 
ATOM   1638 C CG  . TYR A 1 241 ? 122.429 122.044 106.068 1.00 37.72  ? 241 TYR A CG  1 
ATOM   1639 C CD1 . TYR A 1 241 ? 121.421 122.943 105.781 1.00 37.72  ? 241 TYR A CD1 1 
ATOM   1640 C CD2 . TYR A 1 241 ? 123.619 122.157 105.373 1.00 37.72  ? 241 TYR A CD2 1 
ATOM   1641 C CE1 . TYR A 1 241 ? 121.578 123.901 104.811 1.00 37.72  ? 241 TYR A CE1 1 
ATOM   1642 C CE2 . TYR A 1 241 ? 123.787 123.116 104.404 1.00 37.72  ? 241 TYR A CE2 1 
ATOM   1643 C CZ  . TYR A 1 241 ? 122.761 123.985 104.125 1.00 37.72  ? 241 TYR A CZ  1 
ATOM   1644 O OH  . TYR A 1 241 ? 122.918 124.946 103.154 1.00 37.72  ? 241 TYR A OH  1 
ATOM   1645 N N   . LEU A 1 242 ? 123.325 118.337 105.841 1.00 37.39  ? 242 LEU A N   1 
ATOM   1646 C CA  . LEU A 1 242 ? 124.064 117.658 104.782 1.00 37.39  ? 242 LEU A CA  1 
ATOM   1647 C C   . LEU A 1 242 ? 123.258 116.507 104.193 1.00 37.39  ? 242 LEU A C   1 
ATOM   1648 O O   . LEU A 1 242 ? 123.300 116.271 102.980 1.00 37.39  ? 242 LEU A O   1 
ATOM   1649 C CB  . LEU A 1 242 ? 125.404 117.161 105.313 1.00 37.39  ? 242 LEU A CB  1 
ATOM   1650 C CG  . LEU A 1 242 ? 126.578 118.110 105.090 1.00 37.39  ? 242 LEU A CG  1 
ATOM   1651 C CD1 . LEU A 1 242 ? 127.828 117.580 105.768 1.00 37.39  ? 242 LEU A CD1 1 
ATOM   1652 C CD2 . LEU A 1 242 ? 126.816 118.311 103.608 1.00 37.39  ? 242 LEU A CD2 1 
ATOM   1653 N N   . ALA A 1 243 ? 122.526 115.775 105.034 1.00 36.43  ? 243 ALA A N   1 
ATOM   1654 C CA  . ALA A 1 243 ? 121.642 114.733 104.530 1.00 36.43  ? 243 ALA A CA  1 
ATOM   1655 C C   . ALA A 1 243 ? 120.543 115.315 103.659 1.00 36.43  ? 243 ALA A C   1 
ATOM   1656 O O   . ALA A 1 243 ? 120.114 114.677 102.693 1.00 36.43  ? 243 ALA A O   1 
ATOM   1657 C CB  . ALA A 1 243 ? 121.037 113.949 105.690 1.00 36.43  ? 243 ALA A CB  1 
ATOM   1658 N N   . GLY A 1 244 ? 120.069 116.515 103.990 1.00 36.25  ? 244 GLY A N   1 
ATOM   1659 C CA  . GLY A 1 244 ? 119.112 117.180 103.124 1.00 36.25  ? 244 GLY A CA  1 
ATOM   1660 C C   . GLY A 1 244 ? 119.714 117.573 101.790 1.00 36.25  ? 244 GLY A C   1 
ATOM   1661 O O   . GLY A 1 244 ? 119.091 117.392 100.741 1.00 36.25  ? 244 GLY A O   1 
ATOM   1662 N N   . LEU A 1 245 ? 120.931 118.122 101.810 1.00 36.29  ? 245 LEU A N   1 
ATOM   1663 C CA  . LEU A 1 245 ? 121.585 118.510 100.564 1.00 36.29  ? 245 LEU A CA  1 
ATOM   1664 C C   . LEU A 1 245 ? 121.830 117.303 99.672  1.00 36.29  ? 245 LEU A C   1 
ATOM   1665 O O   . LEU A 1 245 ? 121.608 117.361 98.458  1.00 36.29  ? 245 LEU A O   1 
ATOM   1666 C CB  . LEU A 1 245 ? 122.900 119.224 100.860 1.00 36.29  ? 245 LEU A CB  1 
ATOM   1667 C CG  . LEU A 1 245 ? 122.823 120.694 101.258 1.00 36.29  ? 245 LEU A CG  1 
ATOM   1668 C CD1 . LEU A 1 245 ? 124.208 121.202 101.581 1.00 36.29  ? 245 LEU A CD1 1 
ATOM   1669 C CD2 . LEU A 1 245 ? 122.199 121.513 100.146 1.00 36.29  ? 245 LEU A CD2 1 
ATOM   1670 N N   . THR A 1 246 ? 122.288 116.198 100.258 1.00 37.00  ? 246 THR A N   1 
ATOM   1671 C CA  . THR A 1 246 ? 122.577 114.975 99.523  1.00 37.00  ? 246 THR A CA  1 
ATOM   1672 C C   . THR A 1 246 ? 121.427 113.973 99.588  1.00 37.00  ? 246 THR A C   1 
ATOM   1673 O O   . THR A 1 246 ? 121.654 112.762 99.509  1.00 37.00  ? 246 THR A O   1 
ATOM   1674 C CB  . THR A 1 246 ? 123.860 114.343 100.051 1.00 37.00  ? 246 THR A CB  1 
ATOM   1675 O OG1 . THR A 1 246 ? 123.630 113.830 101.367 1.00 37.00  ? 246 THR A OG1 1 
ATOM   1676 C CG2 . THR A 1 246 ? 124.962 115.376 100.109 1.00 37.00  ? 246 THR A CG2 1 
ATOM   1677 N N   . GLY A 1 247 ? 120.194 114.460 99.741  1.00 38.44  ? 247 GLY A N   1 
ATOM   1678 C CA  . GLY A 1 247 ? 119.065 113.558 99.895  1.00 38.44  ? 247 GLY A CA  1 
ATOM   1679 C C   . GLY A 1 247 ? 118.755 112.759 98.645  1.00 38.44  ? 247 GLY A C   1 
ATOM   1680 O O   . GLY A 1 247 ? 118.483 111.558 98.718  1.00 38.44  ? 247 GLY A O   1 
ATOM   1681 N N   . HIS A 1 248 ? 118.786 113.407 97.487  1.00 39.85  ? 248 HIS A N   1 
ATOM   1682 C CA  . HIS A 1 248 ? 118.404 112.787 96.223  1.00 39.85  ? 248 HIS A CA  1 
ATOM   1683 C C   . HIS A 1 248 ? 119.516 112.951 95.200  1.00 39.85  ? 248 HIS A C   1 
ATOM   1684 O O   . HIS A 1 248 ? 119.293 113.355 94.057  1.00 39.85  ? 248 HIS A O   1 
ATOM   1685 C CB  . HIS A 1 248 ? 117.098 113.376 95.698  1.00 39.85  ? 248 HIS A CB  1 
ATOM   1686 C CG  . HIS A 1 248 ? 115.949 113.244 96.649  1.00 39.85  ? 248 HIS A CG  1 
ATOM   1687 N ND1 . HIS A 1 248 ? 115.815 112.177 97.511  1.00 39.85  ? 248 HIS A ND1 1 
ATOM   1688 C CD2 . HIS A 1 248 ? 114.880 114.045 96.873  1.00 39.85  ? 248 HIS A CD2 1 
ATOM   1689 C CE1 . HIS A 1 248 ? 114.713 112.327 98.226  1.00 39.85  ? 248 HIS A CE1 1 
ATOM   1690 N NE2 . HIS A 1 248 ? 114.128 113.452 97.858  1.00 39.85  ? 248 HIS A NE2 1 
ATOM   1691 N N   . VAL A 1 249 ? 120.743 112.635 95.602  1.00 40.15  ? 249 VAL A N   1 
ATOM   1692 C CA  . VAL A 1 249 ? 121.915 112.928 94.788  1.00 40.15  ? 249 VAL A CA  1 
ATOM   1693 C C   . VAL A 1 249 ? 122.611 111.674 94.283  1.00 40.15  ? 249 VAL A C   1 
ATOM   1694 O O   . VAL A 1 249 ? 123.391 111.763 93.322  1.00 40.15  ? 249 VAL A O   1 
ATOM   1695 C CB  . VAL A 1 249 ? 122.920 113.810 95.561  1.00 40.15  ? 249 VAL A CB  1 
ATOM   1696 C CG1 . VAL A 1 249 ? 123.536 113.028 96.704  1.00 40.15  ? 249 VAL A CG1 1 
ATOM   1697 C CG2 . VAL A 1 249 ? 123.964 114.424 94.645  1.00 40.15  ? 249 VAL A CG2 1 
ATOM   1698 N N   . SER A 1 250 ? 122.336 110.507 94.855  1.00 42.74  ? 250 SER A N   1 
ATOM   1699 C CA  . SER A 1 250 ? 123.023 109.288 94.450  1.00 42.74  ? 250 SER A CA  1 
ATOM   1700 C C   . SER A 1 250 ? 122.245 108.087 94.973  1.00 42.74  ? 250 SER A C   1 
ATOM   1701 O O   . SER A 1 250 ? 121.121 108.219 95.468  1.00 42.74  ? 250 SER A O   1 
ATOM   1702 C CB  . SER A 1 250 ? 124.471 109.288 94.952  1.00 42.74  ? 250 SER A CB  1 
ATOM   1703 O OG  . SER A 1 250 ? 124.516 109.341 96.367  1.00 42.74  ? 250 SER A OG  1 
ATOM   1704 N N   . SER A 1 251 ? 122.846 106.911 94.853  1.00 45.56  ? 251 SER A N   1 
ATOM   1705 C CA  . SER A 1 251 ? 122.249 105.672 95.313  1.00 45.56  ? 251 SER A CA  1 
ATOM   1706 C C   . SER A 1 251 ? 122.358 105.544 96.831  1.00 45.56  ? 251 SER A C   1 
ATOM   1707 O O   . SER A 1 251 ? 123.242 106.137 97.454  1.00 45.56  ? 251 SER A O   1 
ATOM   1708 C CB  . SER A 1 251 ? 122.928 104.489 94.630  1.00 45.56  ? 251 SER A CB  1 
ATOM   1709 O OG  . SER A 1 251 ? 124.283 104.382 95.029  1.00 45.56  ? 251 SER A OG  1 
ATOM   1710 N N   . PRO A 1 252 ? 121.466 104.772 97.447  1.00 45.83  ? 252 PRO A N   1 
ATOM   1711 C CA  . PRO A 1 252 ? 121.472 104.622 98.913  1.00 45.83  ? 252 PRO A CA  1 
ATOM   1712 C C   . PRO A 1 252 ? 122.788 104.093 99.463  1.00 45.83  ? 252 PRO A C   1 
ATOM   1713 O O   . PRO A 1 252 ? 123.171 104.474 100.579 1.00 45.83  ? 252 PRO A O   1 
ATOM   1714 C CB  . PRO A 1 252 ? 120.325 103.634 99.169  1.00 45.83  ? 252 PRO A CB  1 
ATOM   1715 C CG  . PRO A 1 252 ? 119.392 103.856 98.031  1.00 45.83  ? 252 PRO A CG  1 
ATOM   1716 C CD  . PRO A 1 252 ? 120.246 104.206 96.840  1.00 45.83  ? 252 PRO A CD  1 
ATOM   1717 N N   . PRO A 1 253 ? 123.509 103.208 98.755  1.00 46.17  ? 253 PRO A N   1 
ATOM   1718 C CA  . PRO A 1 253 ? 124.815 102.778 99.289  1.00 46.17  ? 253 PRO A CA  1 
ATOM   1719 C C   . PRO A 1 253 ? 125.793 103.914 99.529  1.00 46.17  ? 253 PRO A C   1 
ATOM   1720 O O   . PRO A 1 253 ? 126.683 103.777 100.377 1.00 46.17  ? 253 PRO A O   1 
ATOM   1721 C CB  . PRO A 1 253 ? 125.337 101.805 98.220  1.00 46.17  ? 253 PRO A CB  1 
ATOM   1722 C CG  . PRO A 1 253 ? 124.423 101.951 97.058  1.00 46.17  ? 253 PRO A CG  1 
ATOM   1723 C CD  . PRO A 1 253 ? 123.114 102.333 97.638  1.00 46.17  ? 253 PRO A CD  1 
ATOM   1724 N N   . VAL A 1 254 ? 125.666 105.027 98.812  1.00 43.46  ? 254 VAL A N   1 
ATOM   1725 C CA  . VAL A 1 254 ? 126.534 106.182 99.016  1.00 43.46  ? 254 VAL A CA  1 
ATOM   1726 C C   . VAL A 1 254 ? 125.778 107.437 99.424  1.00 43.46  ? 254 VAL A C   1 
ATOM   1727 O O   . VAL A 1 254 ? 126.421 108.424 99.811  1.00 43.46  ? 254 VAL A O   1 
ATOM   1728 C CB  . VAL A 1 254 ? 127.390 106.468 97.763  1.00 43.46  ? 254 VAL A CB  1 
ATOM   1729 C CG1 . VAL A 1 254 ? 128.294 105.291 97.472  1.00 43.46  ? 254 VAL A CG1 1 
ATOM   1730 C CG2 . VAL A 1 254 ? 126.502 106.748 96.572  1.00 43.46  ? 254 VAL A CG2 1 
ATOM   1731 N N   . ASN A 1 255 ? 124.444 107.445 99.353  1.00 40.91  ? 255 ASN A N   1 
ATOM   1732 C CA  . ASN A 1 255 ? 123.684 108.640 99.710  1.00 40.91  ? 255 ASN A CA  1 
ATOM   1733 C C   . ASN A 1 255 ? 123.844 108.985 101.185 1.00 40.91  ? 255 ASN A C   1 
ATOM   1734 O O   . ASN A 1 255 ? 124.130 110.135 101.538 1.00 40.91  ? 255 ASN A O   1 
ATOM   1735 C CB  . ASN A 1 255 ? 122.210 108.441 99.366  1.00 40.91  ? 255 ASN A CB  1 
ATOM   1736 C CG  . ASN A 1 255 ? 121.449 109.741 99.311  1.00 40.91  ? 255 ASN A CG  1 
ATOM   1737 O OD1 . ASN A 1 255 ? 120.472 109.934 100.034 1.00 40.91  ? 255 ASN A OD1 1 
ATOM   1738 N ND2 . ASN A 1 255 ? 121.888 110.646 98.446  1.00 40.91  ? 255 ASN A ND2 1 
ATOM   1739 N N   . GLN A 1 256 ? 123.650 108.003 102.061 1.00 40.36  ? 256 GLN A N   1 
ATOM   1740 C CA  . GLN A 1 256 ? 123.829 108.121 103.506 1.00 40.36  ? 256 GLN A CA  1 
ATOM   1741 C C   . GLN A 1 256 ? 122.910 109.151 104.151 1.00 40.36  ? 256 GLN A C   1 
ATOM   1742 O O   . GLN A 1 256 ? 123.104 109.493 105.322 1.00 40.36  ? 256 GLN A O   1 
ATOM   1743 C CB  . GLN A 1 256 ? 125.285 108.433 103.872 1.00 40.36  ? 256 GLN A CB  1 
ATOM   1744 C CG  . GLN A 1 256 ? 126.293 107.458 103.296 1.00 40.36  ? 256 GLN A CG  1 
ATOM   1745 C CD  . GLN A 1 256 ? 126.453 106.219 104.149 1.00 40.36  ? 256 GLN A CD  1 
ATOM   1746 O OE1 . GLN A 1 256 ? 126.441 106.292 105.376 1.00 40.36  ? 256 GLN A OE1 1 
ATOM   1747 N NE2 . GLN A 1 256 ? 126.604 105.071 103.501 1.00 40.36  ? 256 GLN A NE2 1 
ATOM   1748 N N   . SER A 1 257 ? 121.916 109.665 103.427 1.00 40.50  ? 257 SER A N   1 
ATOM   1749 C CA  . SER A 1 257 ? 120.963 110.578 104.050 1.00 40.50  ? 257 SER A CA  1 
ATOM   1750 C C   . SER A 1 257 ? 120.027 109.836 104.995 1.00 40.50  ? 257 SER A C   1 
ATOM   1751 O O   . SER A 1 257 ? 119.748 110.309 106.106 1.00 40.50  ? 257 SER A O   1 
ATOM   1752 C CB  . SER A 1 257 ? 120.166 111.316 102.976 1.00 40.50  ? 257 SER A CB  1 
ATOM   1753 O OG  . SER A 1 257 ? 119.318 112.293 103.551 1.00 40.50  ? 257 SER A OG  1 
ATOM   1754 N N   . LEU A 1 258 ? 119.544 108.667 104.572 1.00 41.42  ? 258 LEU A N   1 
ATOM   1755 C CA  . LEU A 1 258 ? 118.618 107.898 105.395 1.00 41.42  ? 258 LEU A CA  1 
ATOM   1756 C C   . LEU A 1 258 ? 119.268 107.477 106.703 1.00 41.42  ? 258 LEU A C   1 
ATOM   1757 O O   . LEU A 1 258 ? 118.665 107.602 107.775 1.00 41.42  ? 258 LEU A O   1 
ATOM   1758 C CB  . LEU A 1 258 ? 118.128 106.675 104.619 1.00 41.42  ? 258 LEU A CB  1 
ATOM   1759 C CG  . LEU A 1 258 ? 117.169 105.723 105.332 1.00 41.42  ? 258 LEU A CG  1 
ATOM   1760 C CD1 . LEU A 1 258 ? 116.056 106.484 106.035 1.00 41.42  ? 258 LEU A CD1 1 
ATOM   1761 C CD2 . LEU A 1 258 ? 116.594 104.717 104.348 1.00 41.42  ? 258 LEU A CD2 1 
ATOM   1762 N N   . THR A 1 259 ? 120.504 106.976 106.637 1.00 40.89  ? 259 THR A N   1 
ATOM   1763 C CA  . THR A 1 259 ? 121.180 106.558 107.858 1.00 40.89  ? 259 THR A CA  1 
ATOM   1764 C C   . THR A 1 259 ? 121.481 107.748 108.755 1.00 40.89  ? 259 THR A C   1 
ATOM   1765 O O   . THR A 1 259 ? 121.359 107.646 109.979 1.00 40.89  ? 259 THR A O   1 
ATOM   1766 C CB  . THR A 1 259 ? 122.460 105.787 107.539 1.00 40.89  ? 259 THR A CB  1 
ATOM   1767 O OG1 . THR A 1 259 ? 123.123 105.444 108.762 1.00 40.89  ? 259 THR A OG1 1 
ATOM   1768 C CG2 . THR A 1 259 ? 123.395 106.605 106.681 1.00 40.89  ? 259 THR A CG2 1 
ATOM   1769 N N   . ILE A 1 260 ? 121.850 108.890 108.170 1.00 41.06  ? 260 ILE A N   1 
ATOM   1770 C CA  . ILE A 1 260 ? 122.125 110.068 108.986 1.00 41.06  ? 260 ILE A CA  1 
ATOM   1771 C C   . ILE A 1 260 ? 120.875 110.476 109.747 1.00 41.06  ? 260 ILE A C   1 
ATOM   1772 O O   . ILE A 1 260 ? 120.918 110.712 110.959 1.00 41.06  ? 260 ILE A O   1 
ATOM   1773 C CB  . ILE A 1 260 ? 122.661 111.222 108.121 1.00 41.06  ? 260 ILE A CB  1 
ATOM   1774 C CG1 . ILE A 1 260 ? 124.161 111.069 107.893 1.00 41.06  ? 260 ILE A CG1 1 
ATOM   1775 C CG2 . ILE A 1 260 ? 122.400 112.554 108.795 1.00 41.06  ? 260 ILE A CG2 1 
ATOM   1776 C CD1 . ILE A 1 260 ? 124.718 112.027 106.870 1.00 41.06  ? 260 ILE A CD1 1 
ATOM   1777 N N   . MET A 1 261 ? 119.737 110.547 109.056 1.00 43.05  ? 261 MET A N   1 
ATOM   1778 C CA  . MET A 1 261 ? 118.518 110.968 109.737 1.00 43.05  ? 261 MET A CA  1 
ATOM   1779 C C   . MET A 1 261 ? 118.060 109.942 110.767 1.00 43.05  ? 261 MET A C   1 
ATOM   1780 O O   . MET A 1 261 ? 117.694 110.308 111.891 1.00 43.05  ? 261 MET A O   1 
ATOM   1781 C CB  . MET A 1 261 ? 117.418 111.259 108.723 1.00 43.05  ? 261 MET A CB  1 
ATOM   1782 C CG  . MET A 1 261 ? 117.713 112.491 107.901 1.00 43.05  ? 261 MET A CG  1 
ATOM   1783 S SD  . MET A 1 261 ? 117.465 114.020 108.831 1.00 43.05  ? 261 MET A SD  1 
ATOM   1784 C CE  . MET A 1 261 ? 116.119 113.576 109.924 1.00 43.05  ? 261 MET A CE  1 
ATOM   1785 N N   . VAL A 1 262 ? 118.092 108.653 110.421 1.00 41.56  ? 262 VAL A N   1 
ATOM   1786 C CA  . VAL A 1 262 ? 117.667 107.637 111.378 1.00 41.56  ? 262 VAL A CA  1 
ATOM   1787 C C   . VAL A 1 262 ? 118.539 107.700 112.621 1.00 41.56  ? 262 VAL A C   1 
ATOM   1788 O O   . VAL A 1 262 ? 118.039 107.702 113.753 1.00 41.56  ? 262 VAL A O   1 
ATOM   1789 C CB  . VAL A 1 262 ? 117.703 106.240 110.736 1.00 41.56  ? 262 VAL A CB  1 
ATOM   1790 C CG1 . VAL A 1 262 ? 117.606 105.174 111.807 1.00 41.56  ? 262 VAL A CG1 1 
ATOM   1791 C CG2 . VAL A 1 262 ? 116.577 106.092 109.738 1.00 41.56  ? 262 VAL A CG2 1 
ATOM   1792 N N   . GLY A 1 263 ? 119.853 107.799 112.426 1.00 40.63  ? 263 GLY A N   1 
ATOM   1793 C CA  . GLY A 1 263 ? 120.756 107.875 113.555 1.00 40.63  ? 263 GLY A CA  1 
ATOM   1794 C C   . GLY A 1 263 ? 120.558 109.122 114.385 1.00 40.63  ? 263 GLY A C   1 
ATOM   1795 O O   . GLY A 1 263 ? 120.633 109.073 115.608 1.00 40.63  ? 263 GLY A O   1 
ATOM   1796 N N   . VAL A 1 264 ? 120.296 110.255 113.738 1.00 40.89  ? 264 VAL A N   1 
ATOM   1797 C CA  . VAL A 1 264 ? 120.153 111.503 114.478 1.00 40.89  ? 264 VAL A CA  1 
ATOM   1798 C C   . VAL A 1 264 ? 118.896 111.486 115.344 1.00 40.89  ? 264 VAL A C   1 
ATOM   1799 O O   . VAL A 1 264 ? 118.951 111.796 116.541 1.00 40.89  ? 264 VAL A O   1 
ATOM   1800 C CB  . VAL A 1 264 ? 120.168 112.696 113.512 1.00 40.89  ? 264 VAL A CB  1 
ATOM   1801 C CG1 . VAL A 1 264 ? 119.627 113.906 114.197 1.00 40.89  ? 264 VAL A CG1 1 
ATOM   1802 C CG2 . VAL A 1 264 ? 121.584 112.963 113.046 1.00 40.89  ? 264 VAL A CG2 1 
ATOM   1803 N N   . ASN A 1 265 ? 117.744 111.118 114.768 1.00 44.16  ? 265 ASN A N   1 
ATOM   1804 C CA  . ASN A 1 265 ? 116.539 111.045 115.597 1.00 44.16  ? 265 ASN A CA  1 
ATOM   1805 C C   . ASN A 1 265 ? 116.643 109.961 116.665 1.00 44.16  ? 265 ASN A C   1 
ATOM   1806 O O   . ASN A 1 265 ? 116.222 110.175 117.809 1.00 44.16  ? 265 ASN A O   1 
ATOM   1807 C CB  . ASN A 1 265 ? 115.264 110.870 114.764 1.00 44.16  ? 265 ASN A CB  1 
ATOM   1808 C CG  . ASN A 1 265 ? 115.155 111.862 113.620 1.00 44.16  ? 265 ASN A CG  1 
ATOM   1809 O OD1 . ASN A 1 265 ? 114.366 112.790 113.646 1.00 44.16  ? 265 ASN A OD1 1 
ATOM   1810 N ND2 . ASN A 1 265 ? 115.975 111.657 112.597 1.00 44.16  ? 265 ASN A ND2 1 
ATOM   1811 N N   . LEU A 1 266 ? 117.190 108.791 116.322 1.00 42.29  ? 266 LEU A N   1 
ATOM   1812 C CA  . LEU A 1 266 ? 117.347 107.751 117.331 1.00 42.29  ? 266 LEU A CA  1 
ATOM   1813 C C   . LEU A 1 266 ? 118.281 108.203 118.443 1.00 42.29  ? 266 LEU A C   1 
ATOM   1814 O O   . LEU A 1 266 ? 118.031 107.929 119.621 1.00 42.29  ? 266 LEU A O   1 
ATOM   1815 C CB  . LEU A 1 266 ? 117.863 106.465 116.692 1.00 42.29  ? 266 LEU A CB  1 
ATOM   1816 C CG  . LEU A 1 266 ? 116.846 105.574 115.983 1.00 42.29  ? 266 LEU A CG  1 
ATOM   1817 C CD1 . LEU A 1 266 ? 117.460 104.225 115.668 1.00 42.29  ? 266 LEU A CD1 1 
ATOM   1818 C CD2 . LEU A 1 266 ? 115.592 105.410 116.821 1.00 42.29  ? 266 LEU A CD2 1 
ATOM   1819 N N   . LEU A 1 267 ? 119.356 108.911 118.091 1.00 41.24  ? 267 LEU A N   1 
ATOM   1820 C CA  . LEU A 1 267 ? 120.287 109.408 119.091 1.00 41.24  ? 267 LEU A CA  1 
ATOM   1821 C C   . LEU A 1 267 ? 119.624 110.427 119.999 1.00 41.24  ? 267 LEU A C   1 
ATOM   1822 O O   . LEU A 1 267 ? 119.810 110.389 121.216 1.00 41.24  ? 267 LEU A O   1 
ATOM   1823 C CB  . LEU A 1 267 ? 121.512 110.011 118.408 1.00 41.24  ? 267 LEU A CB  1 
ATOM   1824 C CG  . LEU A 1 267 ? 122.683 110.412 119.301 1.00 41.24  ? 267 LEU A CG  1 
ATOM   1825 C CD1 . LEU A 1 267 ? 123.169 109.224 120.099 1.00 41.24  ? 267 LEU A CD1 1 
ATOM   1826 C CD2 . LEU A 1 267 ? 123.811 110.994 118.468 1.00 41.24  ? 267 LEU A CD2 1 
ATOM   1827 N N   . VAL A 1 268 ? 118.833 111.337 119.432 1.00 39.54  ? 268 VAL A N   1 
ATOM   1828 C CA  . VAL A 1 268 ? 118.167 112.342 120.257 1.00 39.54  ? 268 VAL A CA  1 
ATOM   1829 C C   . VAL A 1 268 ? 117.179 111.681 121.211 1.00 39.54  ? 268 VAL A C   1 
ATOM   1830 O O   . VAL A 1 268 ? 117.169 111.964 122.417 1.00 39.54  ? 268 VAL A O   1 
ATOM   1831 C CB  . VAL A 1 268 ? 117.481 113.396 119.373 1.00 39.54  ? 268 VAL A CB  1 
ATOM   1832 C CG1 . VAL A 1 268 ? 116.686 114.347 120.225 1.00 39.54  ? 268 VAL A CG1 1 
ATOM   1833 C CG2 . VAL A 1 268 ? 118.519 114.164 118.580 1.00 39.54  ? 268 VAL A CG2 1 
ATOM   1834 N N   . LEU A 1 269 ? 116.350 110.770 120.692 1.00 39.58  ? 269 LEU A N   1 
ATOM   1835 C CA  . LEU A 1 269 ? 115.373 110.090 121.538 1.00 39.58  ? 269 LEU A CA  1 
ATOM   1836 C C   . LEU A 1 269 ? 116.054 109.284 122.638 1.00 39.58  ? 269 LEU A C   1 
ATOM   1837 O O   . LEU A 1 269 ? 115.698 109.397 123.819 1.00 39.58  ? 269 LEU A O   1 
ATOM   1838 C CB  . LEU A 1 269 ? 114.487 109.184 120.685 1.00 39.58  ? 269 LEU A CB  1 
ATOM   1839 C CG  . LEU A 1 269 ? 113.290 109.831 119.991 1.00 39.58  ? 269 LEU A CG  1 
ATOM   1840 C CD1 . LEU A 1 269 ? 112.631 108.843 119.044 1.00 39.58  ? 269 LEU A CD1 1 
ATOM   1841 C CD2 . LEU A 1 269 ? 112.290 110.344 121.016 1.00 39.58  ? 269 LEU A CD2 1 
ATOM   1842 N N   . ALA A 1 270 ? 117.047 108.469 122.270 1.00 39.34  ? 270 ALA A N   1 
ATOM   1843 C CA  . ALA A 1 270 ? 117.728 107.635 123.250 1.00 39.34  ? 270 ALA A CA  1 
ATOM   1844 C C   . ALA A 1 270 ? 118.462 108.478 124.277 1.00 39.34  ? 270 ALA A C   1 
ATOM   1845 O O   . ALA A 1 270 ? 118.413 108.186 125.475 1.00 39.34  ? 270 ALA A O   1 
ATOM   1846 C CB  . ALA A 1 270 ? 118.697 106.686 122.549 1.00 39.34  ? 270 ALA A CB  1 
ATOM   1847 N N   . ALA A 1 271 ? 119.147 109.529 123.831 1.00 39.91  ? 271 ALA A N   1 
ATOM   1848 C CA  . ALA A 1 271 ? 119.885 110.387 124.744 1.00 39.91  ? 271 ALA A CA  1 
ATOM   1849 C C   . ALA A 1 271 ? 118.953 111.049 125.749 1.00 39.91  ? 271 ALA A C   1 
ATOM   1850 O O   . ALA A 1 271 ? 119.213 111.027 126.958 1.00 39.91  ? 271 ALA A O   1 
ATOM   1851 C CB  . ALA A 1 271 ? 120.665 111.425 123.941 1.00 39.91  ? 271 ALA A CB  1 
ATOM   1852 N N   . GLY A 1 272 ? 117.846 111.624 125.272 1.00 38.27  ? 272 GLY A N   1 
ATOM   1853 C CA  . GLY A 1 272 ? 116.907 112.253 126.189 1.00 38.27  ? 272 GLY A CA  1 
ATOM   1854 C C   . GLY A 1 272 ? 116.317 111.265 127.177 1.00 38.27  ? 272 GLY A C   1 
ATOM   1855 O O   . GLY A 1 272 ? 116.256 111.529 128.385 1.00 38.27  ? 272 GLY A O   1 
ATOM   1856 N N   . LEU A 1 273 ? 115.885 110.104 126.677 1.00 39.38  ? 273 LEU A N   1 
ATOM   1857 C CA  . LEU A 1 273 ? 115.269 109.108 127.543 1.00 39.38  ? 273 LEU A CA  1 
ATOM   1858 C C   . LEU A 1 273 ? 116.248 108.619 128.601 1.00 39.38  ? 273 LEU A C   1 
ATOM   1859 O O   . LEU A 1 273 ? 115.899 108.509 129.782 1.00 39.38  ? 273 LEU A O   1 
ATOM   1860 C CB  . LEU A 1 273 ? 114.751 107.939 126.709 1.00 39.38  ? 273 LEU A CB  1 
ATOM   1861 C CG  . LEU A 1 273 ? 114.109 106.801 127.498 1.00 39.38  ? 273 LEU A CG  1 
ATOM   1862 C CD1 . LEU A 1 273 ? 112.911 107.307 128.281 1.00 39.38  ? 273 LEU A CD1 1 
ATOM   1863 C CD2 . LEU A 1 273 ? 113.704 105.673 126.567 1.00 39.38  ? 273 LEU A CD2 1 
ATOM   1864 N N   . LEU A 1 274 ? 117.484 108.325 128.196 1.00 40.22  ? 274 LEU A N   1 
ATOM   1865 C CA  . LEU A 1 274 ? 118.459 107.795 129.139 1.00 40.22  ? 274 LEU A CA  1 
ATOM   1866 C C   . LEU A 1 274 ? 118.887 108.852 130.145 1.00 40.22  ? 274 LEU A C   1 
ATOM   1867 O O   . LEU A 1 274 ? 119.104 108.537 131.319 1.00 40.22  ? 274 LEU A O   1 
ATOM   1868 C CB  . LEU A 1 274 ? 119.658 107.230 128.383 1.00 40.22  ? 274 LEU A CB  1 
ATOM   1869 C CG  . LEU A 1 274 ? 119.309 106.037 127.489 1.00 40.22  ? 274 LEU A CG  1 
ATOM   1870 C CD1 . LEU A 1 274 ? 120.554 105.396 126.906 1.00 40.22  ? 274 LEU A CD1 1 
ATOM   1871 C CD2 . LEU A 1 274 ? 118.483 105.019 128.254 1.00 40.22  ? 274 LEU A CD2 1 
ATOM   1872 N N   . PHE A 1 275 ? 118.929 110.105 129.763 1.00 41.33  ? 275 PHE A N   1 
ATOM   1873 C CA  . PHE A 1 275 ? 119.228 111.189 130.698 1.00 41.33  ? 275 PHE A CA  1 
ATOM   1874 C C   . PHE A 1 275 ? 118.158 111.417 131.707 1.00 41.33  ? 275 PHE A C   1 
ATOM   1875 O O   . PHE A 1 275 ? 118.446 111.715 132.850 1.00 41.33  ? 275 PHE A O   1 
ATOM   1876 C CB  . PHE A 1 275 ? 119.416 112.481 129.948 1.00 41.33  ? 275 PHE A CB  1 
ATOM   1877 C CG  . PHE A 1 275 ? 119.304 113.711 130.803 1.00 41.33  ? 275 PHE A CG  1 
ATOM   1878 C CD1 . PHE A 1 275 ? 120.237 113.976 131.790 1.00 41.33  ? 275 PHE A CD1 1 
ATOM   1879 C CD2 . PHE A 1 275 ? 118.276 114.618 130.600 1.00 41.33  ? 275 PHE A CD2 1 
ATOM   1880 C CE1 . PHE A 1 275 ? 120.133 115.112 132.570 1.00 41.33  ? 275 PHE A CE1 1 
ATOM   1881 C CE2 . PHE A 1 275 ? 118.169 115.754 131.373 1.00 41.33  ? 275 PHE A CE2 1 
ATOM   1882 C CZ  . PHE A 1 275 ? 119.097 116.000 132.361 1.00 41.33  ? 275 PHE A CZ  1 
ATOM   1883 N N   . VAL A 1 276 ? 116.910 111.293 131.298 1.00 39.67  ? 276 VAL A N   1 
ATOM   1884 C CA  . VAL A 1 276 ? 115.814 111.398 132.262 1.00 39.67  ? 276 VAL A CA  1 
ATOM   1885 C C   . VAL A 1 276 ? 115.808 110.198 133.200 1.00 39.67  ? 276 VAL A C   1 
ATOM   1886 O O   . VAL A 1 276 ? 115.622 110.341 134.416 1.00 39.67  ? 276 VAL A O   1 
ATOM   1887 C CB  . VAL A 1 276 ? 114.468 111.551 131.534 1.00 39.67  ? 276 VAL A CB  1 
ATOM   1888 C CG1 . VAL A 1 276 ? 113.330 111.538 132.530 1.00 39.67  ? 276 VAL A CG1 1 
ATOM   1889 C CG2 . VAL A 1 276 ? 114.450 112.833 130.734 1.00 39.67  ? 276 VAL A CG2 1 
ATOM   1890 N N   . VAL A 1 277 ? 116.013 108.999 132.653 1.00 40.96  ? 277 VAL A N   1 
ATOM   1891 C CA  . VAL A 1 277 ? 115.931 107.786 133.460 1.00 40.96  ? 277 VAL A CA  1 
ATOM   1892 C C   . VAL A 1 277 ? 117.064 107.738 134.477 1.00 40.96  ? 277 VAL A C   1 
ATOM   1893 O O   . VAL A 1 277 ? 116.842 107.456 135.660 1.00 40.96  ? 277 VAL A O   1 
ATOM   1894 C CB  . VAL A 1 277 ? 115.927 106.544 132.554 1.00 40.96  ? 277 VAL A CB  1 
ATOM   1895 C CG1 . VAL A 1 277 ? 116.320 105.310 133.339 1.00 40.96  ? 277 VAL A CG1 1 
ATOM   1896 C CG2 . VAL A 1 277 ? 114.557 106.366 131.926 1.00 40.96  ? 277 VAL A CG2 1 
ATOM   1897 N N   . THR A 1 278 ? 118.294 108.020 134.042 1.00 41.84  ? 278 THR A N   1 
ATOM   1898 C CA  . THR A 1 278 ? 119.417 107.999 134.969 1.00 41.84  ? 278 THR A CA  1 
ATOM   1899 C C   . THR A 1 278 ? 119.365 109.148 135.966 1.00 41.84  ? 278 THR A C   1 
ATOM   1900 O O   . THR A 1 278 ? 120.026 109.073 137.005 1.00 41.84  ? 278 THR A O   1 
ATOM   1901 C CB  . THR A 1 278 ? 120.742 108.026 134.206 1.00 41.84  ? 278 THR A CB  1 
ATOM   1902 O OG1 . THR A 1 278 ? 121.802 107.616 135.076 1.00 41.84  ? 278 THR A OG1 1 
ATOM   1903 C CG2 . THR A 1 278 ? 121.040 109.423 133.696 1.00 41.84  ? 278 THR A CG2 1 
ATOM   1904 N N   . ARG A 1 279 ? 118.598 110.205 135.684 1.00 42.61  ? 279 ARG A N   1 
ATOM   1905 C CA  . ARG A 1 279 ? 118.460 111.276 136.666 1.00 42.61  ? 279 ARG A CA  1 
ATOM   1906 C C   . ARG A 1 279 ? 117.398 110.957 137.709 1.00 42.61  ? 279 ARG A C   1 
ATOM   1907 O O   . ARG A 1 279 ? 117.693 110.883 138.906 1.00 42.61  ? 279 ARG A O   1 
ATOM   1908 C CB  . ARG A 1 279 ? 118.134 112.603 135.981 1.00 42.61  ? 279 ARG A CB  1 
ATOM   1909 C CG  . ARG A 1 279 ? 118.069 113.761 136.963 1.00 42.61  ? 279 ARG A CG  1 
ATOM   1910 C CD  . ARG A 1 279 ? 118.209 115.108 136.289 1.00 42.61  ? 279 ARG A CD  1 
ATOM   1911 N NE  . ARG A 1 279 ? 119.556 115.319 135.780 1.00 42.61  ? 279 ARG A NE  1 
ATOM   1912 C CZ  . ARG A 1 279 ? 120.357 116.302 136.165 1.00 42.61  ? 279 ARG A CZ  1 
ATOM   1913 N NH1 . ARG A 1 279 ? 119.980 117.185 137.074 1.00 42.61  ? 279 ARG A NH1 1 
ATOM   1914 N NH2 . ARG A 1 279 ? 121.567 116.401 135.625 1.00 42.61  ? 279 ARG A NH2 1 
ATOM   1915 N N   . TYR A 1 280 ? 116.155 110.765 137.277 1.00 42.25  ? 280 TYR A N   1 
ATOM   1916 C CA  . TYR A 1 280 ? 115.044 110.672 138.215 1.00 42.25  ? 280 TYR A CA  1 
ATOM   1917 C C   . TYR A 1 280 ? 114.772 109.259 138.703 1.00 42.25  ? 280 TYR A C   1 
ATOM   1918 O O   . TYR A 1 280 ? 113.856 109.068 139.508 1.00 42.25  ? 280 TYR A O   1 
ATOM   1919 C CB  . TYR A 1 280 ? 113.775 111.246 137.586 1.00 42.25  ? 280 TYR A CB  1 
ATOM   1920 C CG  . TYR A 1 280 ? 113.709 112.750 137.659 1.00 42.25  ? 280 TYR A CG  1 
ATOM   1921 C CD1 . TYR A 1 280 ? 113.452 113.392 138.858 1.00 42.25  ? 280 TYR A CD1 1 
ATOM   1922 C CD2 . TYR A 1 280 ? 113.914 113.525 136.533 1.00 42.25  ? 280 TYR A CD2 1 
ATOM   1923 C CE1 . TYR A 1 280 ? 113.396 114.763 138.932 1.00 42.25  ? 280 TYR A CE1 1 
ATOM   1924 C CE2 . TYR A 1 280 ? 113.858 114.894 136.597 1.00 42.25  ? 280 TYR A CE2 1 
ATOM   1925 C CZ  . TYR A 1 280 ? 113.599 115.511 137.798 1.00 42.25  ? 280 TYR A CZ  1 
ATOM   1926 O OH  . TYR A 1 280 ? 113.543 116.884 137.864 1.00 42.25  ? 280 TYR A OH  1 
ATOM   1927 N N   . LEU A 1 281 ? 115.537 108.270 138.251 1.00 43.74  ? 281 LEU A N   1 
ATOM   1928 C CA  . LEU A 1 281 ? 115.352 106.888 138.679 1.00 43.74  ? 281 LEU A CA  1 
ATOM   1929 C C   . LEU A 1 281 ? 116.666 106.298 139.169 1.00 43.74  ? 281 LEU A C   1 
ATOM   1930 O O   . LEU A 1 281 ? 117.048 105.184 138.810 1.00 43.74  ? 281 LEU A O   1 
ATOM   1931 C CB  . LEU A 1 281 ? 114.762 106.040 137.560 1.00 43.74  ? 281 LEU A CB  1 
ATOM   1932 C CG  . LEU A 1 281 ? 113.277 106.274 137.294 1.00 43.74  ? 281 LEU A CG  1 
ATOM   1933 C CD1 . LEU A 1 281 ? 112.821 105.519 136.063 1.00 43.74  ? 281 LEU A CD1 1 
ATOM   1934 C CD2 . LEU A 1 281 ? 112.452 105.880 138.503 1.00 43.74  ? 281 LEU A CD2 1 
ATOM   1935 N N   . HIS A 1 282 ? 117.382 107.040 140.015 1.00 49.82  ? 282 HIS A N   1 
ATOM   1936 C CA  . HIS A 1 282 ? 118.543 106.453 140.672 1.00 49.82  ? 282 HIS A CA  1 
ATOM   1937 C C   . HIS A 1 282 ? 118.088 105.680 141.903 1.00 49.82  ? 282 HIS A C   1 
ATOM   1938 O O   . HIS A 1 282 ? 118.664 105.809 142.987 1.00 49.82  ? 282 HIS A O   1 
ATOM   1939 C CB  . HIS A 1 282 ? 119.561 107.531 141.051 1.00 49.82  ? 282 HIS A CB  1 
ATOM   1940 C CG  . HIS A 1 282 ? 118.990 108.642 141.878 1.00 49.82  ? 282 HIS A CG  1 
ATOM   1941 N ND1 . HIS A 1 282 ? 118.579 108.464 143.182 1.00 49.82  ? 282 HIS A ND1 1 
ATOM   1942 C CD2 . HIS A 1 282 ? 118.768 109.946 141.589 1.00 49.82  ? 282 HIS A CD2 1 
ATOM   1943 C CE1 . HIS A 1 282 ? 118.125 109.610 143.658 1.00 49.82  ? 282 HIS A CE1 1 
ATOM   1944 N NE2 . HIS A 1 282 ? 118.229 110.525 142.711 1.00 49.82  ? 282 HIS A NE2 1 
ATOM   1945 N N   . SER A 1 283 ? 117.050 104.870 141.724 1.00 49.56  ? 283 SER A N   1 
ATOM   1946 C CA  . SER A 1 283 ? 116.622 103.886 142.703 1.00 49.56  ? 283 SER A CA  1 
ATOM   1947 C C   . SER A 1 283 ? 116.155 102.610 142.027 1.00 49.56  ? 283 SER A C   1 
ATOM   1948 O O   . SER A 1 283 ? 115.699 101.693 142.717 1.00 49.56  ? 283 SER A O   1 
ATOM   1949 C CB  . SER A 1 283 ? 115.502 104.446 143.591 1.00 49.56  ? 283 SER A CB  1 
ATOM   1950 O OG  . SER A 1 283 ? 115.997 105.449 144.459 1.00 49.56  ? 283 SER A OG  1 
ATOM   1951 N N   . TRP A 1 284 ? 116.255 102.527 140.703 1.00 48.31  ? 284 TRP A N   1 
ATOM   1952 C CA  . TRP A 1 284 ? 115.886 101.346 139.929 1.00 48.31  ? 284 TRP A CA  1 
ATOM   1953 C C   . TRP A 1 284 ? 117.096 100.959 139.094 1.00 48.31  ? 284 TRP A C   1 
ATOM   1954 O O   . TRP A 1 284 ? 117.120 101.171 137.876 1.00 48.31  ? 284 TRP A O   1 
ATOM   1955 C CB  . TRP A 1 284 ? 114.675 101.618 139.036 1.00 48.31  ? 284 TRP A CB  1 
ATOM   1956 C CG  . TRP A 1 284 ? 113.438 102.055 139.760 1.00 48.31  ? 284 TRP A CG  1 
ATOM   1957 C CD1 . TRP A 1 284 ? 113.297 103.150 140.555 1.00 48.31  ? 284 TRP A CD1 1 
ATOM   1958 C CD2 . TRP A 1 284 ? 112.158 101.415 139.730 1.00 48.31  ? 284 TRP A CD2 1 
ATOM   1959 N NE1 . TRP A 1 284 ? 112.014 103.227 141.035 1.00 48.31  ? 284 TRP A NE1 1 
ATOM   1960 C CE2 . TRP A 1 284 ? 111.294 102.173 140.541 1.00 48.31  ? 284 TRP A CE2 1 
ATOM   1961 C CE3 . TRP A 1 284 ? 111.660 100.271 139.101 1.00 48.31  ? 284 TRP A CE3 1 
ATOM   1962 C CZ2 . TRP A 1 284 ? 109.960 101.825 140.741 1.00 48.31  ? 284 TRP A CZ2 1 
ATOM   1963 C CZ3 . TRP A 1 284 ? 110.338 99.926  139.300 1.00 48.31  ? 284 TRP A CZ3 1 
ATOM   1964 C CH2 . TRP A 1 284 ? 109.502 100.700 140.112 1.00 48.31  ? 284 TRP A CH2 1 
ATOM   1965 N N   . PRO A 1 285 ? 118.135 100.405 139.728 1.00 50.09  ? 285 PRO A N   1 
ATOM   1966 C CA  . PRO A 1 285 ? 119.380 100.138 138.989 1.00 50.09  ? 285 PRO A CA  1 
ATOM   1967 C C   . PRO A 1 285 ? 119.192 99.220  137.798 1.00 50.09  ? 285 PRO A C   1 
ATOM   1968 O O   . PRO A 1 285 ? 119.807 99.438  136.744 1.00 50.09  ? 285 PRO A O   1 
ATOM   1969 C CB  . PRO A 1 285 ? 120.287 99.510  140.056 1.00 50.09  ? 285 PRO A CB  1 
ATOM   1970 C CG  . PRO A 1 285 ? 119.354 99.007  141.105 1.00 50.09  ? 285 PRO A CG  1 
ATOM   1971 C CD  . PRO A 1 285 ? 118.220 99.966  141.130 1.00 50.09  ? 285 PRO A CD  1 
ATOM   1972 N N   . ASN A 1 286 ? 118.342 98.202  137.933 1.00 51.18  ? 286 ASN A N   1 
ATOM   1973 C CA  . ASN A 1 286 ? 118.102 97.292  136.820 1.00 51.18  ? 286 ASN A CA  1 
ATOM   1974 C C   . ASN A 1 286 ? 117.456 98.016  135.648 1.00 51.18  ? 286 ASN A C   1 
ATOM   1975 O O   . ASN A 1 286 ? 117.850 97.815  134.494 1.00 51.18  ? 286 ASN A O   1 
ATOM   1976 C CB  . ASN A 1 286 ? 117.239 96.122  137.280 1.00 51.18  ? 286 ASN A CB  1 
ATOM   1977 C CG  . ASN A 1 286 ? 118.059 94.996  137.866 1.00 51.18  ? 286 ASN A CG  1 
ATOM   1978 O OD1 . ASN A 1 286 ? 118.865 94.378  137.174 1.00 51.18  ? 286 ASN A OD1 1 
ATOM   1979 N ND2 . ASN A 1 286 ? 117.862 94.727  139.149 1.00 51.18  ? 286 ASN A ND2 1 
ATOM   1980 N N   . LEU A 1 287 ? 116.467 98.868  135.925 1.00 48.66  ? 287 LEU A N   1 
ATOM   1981 C CA  . LEU A 1 287 ? 115.803 99.604  134.855 1.00 48.66  ? 287 LEU A CA  1 
ATOM   1982 C C   . LEU A 1 287 ? 116.780 100.522 134.138 1.00 48.66  ? 287 LEU A C   1 
ATOM   1983 O O   . LEU A 1 287 ? 116.820 100.563 132.903 1.00 48.66  ? 287 LEU A O   1 
ATOM   1984 C CB  . LEU A 1 287 ? 114.629 100.403 135.417 1.00 48.66  ? 287 LEU A CB  1 
ATOM   1985 C CG  . LEU A 1 287 ? 113.911 101.332 134.437 1.00 48.66  ? 287 LEU A CG  1 
ATOM   1986 C CD1 . LEU A 1 287 ? 113.446 100.564 133.214 1.00 48.66  ? 287 LEU A CD1 1 
ATOM   1987 C CD2 . LEU A 1 287 ? 112.738 102.009 135.116 1.00 48.66  ? 287 LEU A CD2 1 
ATOM   1988 N N   . VAL A 1 288 ? 117.579 101.268 134.901 1.00 46.44  ? 288 VAL A N   1 
ATOM   1989 C CA  . VAL A 1 288 ? 118.517 102.209 134.297 1.00 46.44  ? 288 VAL A CA  1 
ATOM   1990 C C   . VAL A 1 288 ? 119.533 101.464 133.445 1.00 46.44  ? 288 VAL A C   1 
ATOM   1991 O O   . VAL A 1 288 ? 119.829 101.861 132.312 1.00 46.44  ? 288 VAL A O   1 
ATOM   1992 C CB  . VAL A 1 288 ? 119.204 103.056 135.381 1.00 46.44  ? 288 VAL A CB  1 
ATOM   1993 C CG1 . VAL A 1 288 ? 120.255 103.959 134.761 1.00 46.44  ? 288 VAL A CG1 1 
ATOM   1994 C CG2 . VAL A 1 288 ? 118.178 103.873 136.140 1.00 46.44  ? 288 VAL A CG2 1 
ATOM   1995 N N   . PHE A 1 289 ? 120.082 100.368 133.976 1.00 47.88  ? 289 PHE A N   1 
ATOM   1996 C CA  . PHE A 1 289 ? 121.099 99.640  133.228 1.00 47.88  ? 289 PHE A CA  1 
ATOM   1997 C C   . PHE A 1 289 ? 120.516 99.009  131.972 1.00 47.88  ? 289 PHE A C   1 
ATOM   1998 O O   . PHE A 1 289 ? 121.123 99.087  130.896 1.00 47.88  ? 289 PHE A O   1 
ATOM   1999 C CB  . PHE A 1 289 ? 121.744 98.576  134.112 1.00 47.88  ? 289 PHE A CB  1 
ATOM   2000 C CG  . PHE A 1 289 ? 122.651 97.644  133.366 1.00 47.88  ? 289 PHE A CG  1 
ATOM   2001 C CD1 . PHE A 1 289 ? 123.570 98.132  132.455 1.00 47.88  ? 289 PHE A CD1 1 
ATOM   2002 C CD2 . PHE A 1 289 ? 122.585 96.280  133.575 1.00 47.88  ? 289 PHE A CD2 1 
ATOM   2003 C CE1 . PHE A 1 289 ? 124.395 97.280  131.764 1.00 47.88  ? 289 PHE A CE1 1 
ATOM   2004 C CE2 . PHE A 1 289 ? 123.411 95.425  132.890 1.00 47.88  ? 289 PHE A CE2 1 
ATOM   2005 C CZ  . PHE A 1 289 ? 124.318 95.926  131.986 1.00 47.88  ? 289 PHE A CZ  1 
ATOM   2006 N N   . GLY A 1 290 ? 119.338 98.393  132.082 1.00 45.49  ? 290 GLY A N   1 
ATOM   2007 C CA  . GLY A 1 290 ? 118.718 97.810  130.908 1.00 45.49  ? 290 GLY A CA  1 
ATOM   2008 C C   . GLY A 1 290 ? 118.411 98.842  129.845 1.00 45.49  ? 290 GLY A C   1 
ATOM   2009 O O   . GLY A 1 290 ? 118.688 98.627  128.664 1.00 45.49  ? 290 GLY A O   1 
ATOM   2010 N N   . LEU A 1 291 ? 117.863 99.990  130.252 1.00 45.22  ? 291 LEU A N   1 
ATOM   2011 C CA  . LEU A 1 291 ? 117.538 101.035 129.289 1.00 45.22  ? 291 LEU A CA  1 
ATOM   2012 C C   . LEU A 1 291 ? 118.789 101.600 128.632 1.00 45.22  ? 291 LEU A C   1 
ATOM   2013 O O   . LEU A 1 291 ? 118.801 101.836 127.420 1.00 45.22  ? 291 LEU A O   1 
ATOM   2014 C CB  . LEU A 1 291 ? 116.733 102.140 129.968 1.00 45.22  ? 291 LEU A CB  1 
ATOM   2015 C CG  . LEU A 1 291 ? 115.243 101.834 130.125 1.00 45.22  ? 291 LEU A CG  1 
ATOM   2016 C CD1 . LEU A 1 291 ? 114.491 103.046 130.630 1.00 45.22  ? 291 LEU A CD1 1 
ATOM   2017 C CD2 . LEU A 1 291 ? 114.654 101.355 128.812 1.00 45.22  ? 291 LEU A CD2 1 
ATOM   2018 N N   . THR A 1 292 ? 119.854 101.818 129.406 1.00 43.98  ? 292 THR A N   1 
ATOM   2019 C CA  . THR A 1 292 ? 121.074 102.377 128.834 1.00 43.98  ? 292 THR A CA  1 
ATOM   2020 C C   . THR A 1 292 ? 121.714 101.404 127.852 1.00 43.98  ? 292 THR A C   1 
ATOM   2021 O O   . THR A 1 292 ? 122.099 101.789 126.736 1.00 43.98  ? 292 THR A O   1 
ATOM   2022 C CB  . THR A 1 292 ? 122.056 102.736 129.947 1.00 43.98  ? 292 THR A CB  1 
ATOM   2023 O OG1 . THR A 1 292 ? 121.447 103.680 130.835 1.00 43.98  ? 292 THR A OG1 1 
ATOM   2024 C CG2 . THR A 1 292 ? 123.313 103.347 129.362 1.00 43.98  ? 292 THR A CG2 1 
ATOM   2025 N N   . SER A 1 293 ? 121.831 100.133 128.248 1.00 44.98  ? 293 SER A N   1 
ATOM   2026 C CA  . SER A 1 293 ? 122.397 99.133  127.354 1.00 44.98  ? 293 SER A CA  1 
ATOM   2027 C C   . SER A 1 293 ? 121.554 98.987  126.097 1.00 44.98  ? 293 SER A C   1 
ATOM   2028 O O   . SER A 1 293 ? 122.093 98.913  124.987 1.00 44.98  ? 293 SER A O   1 
ATOM   2029 C CB  . SER A 1 293 ? 122.525 97.795  128.076 1.00 44.98  ? 293 SER A CB  1 
ATOM   2030 O OG  . SER A 1 293 ? 123.287 96.877  127.313 1.00 44.98  ? 293 SER A OG  1 
ATOM   2031 N N   . GLY A 1 294 ? 120.227 98.967  126.248 1.00 45.33  ? 294 GLY A N   1 
ATOM   2032 C CA  . GLY A 1 294 ? 119.362 98.857  125.089 1.00 45.33  ? 294 GLY A CA  1 
ATOM   2033 C C   . GLY A 1 294 ? 119.477 100.042 124.154 1.00 45.33  ? 294 GLY A C   1 
ATOM   2034 O O   . GLY A 1 294 ? 119.503 99.877  122.936 1.00 45.33  ? 294 GLY A O   1 
ATOM   2035 N N   . GLY A 1 295 ? 119.555 101.252 124.707 1.00 44.34  ? 295 GLY A N   1 
ATOM   2036 C CA  . GLY A 1 295 ? 119.680 102.426 123.860 1.00 44.34  ? 295 GLY A CA  1 
ATOM   2037 C C   . GLY A 1 295 ? 120.980 102.448 123.084 1.00 44.34  ? 295 GLY A C   1 
ATOM   2038 O O   . GLY A 1 295 ? 120.993 102.707 121.875 1.00 44.34  ? 295 GLY A O   1 
ATOM   2039 N N   . ILE A 1 296 ? 122.093 102.162 123.763 1.00 44.62  ? 296 ILE A N   1 
ATOM   2040 C CA  . ILE A 1 296 ? 123.382 102.139 123.074 1.00 44.62  ? 296 ILE A CA  1 
ATOM   2041 C C   . ILE A 1 296 ? 123.391 101.052 122.007 1.00 44.62  ? 296 ILE A C   1 
ATOM   2042 O O   . ILE A 1 296 ? 123.826 101.276 120.869 1.00 44.62  ? 296 ILE A O   1 
ATOM   2043 C CB  . ILE A 1 296 ? 124.532 101.958 124.079 1.00 44.62  ? 296 ILE A CB  1 
ATOM   2044 C CG1 . ILE A 1 296 ? 124.592 103.144 125.040 1.00 44.62  ? 296 ILE A CG1 1 
ATOM   2045 C CG2 . ILE A 1 296 ? 125.854 101.813 123.349 1.00 44.62  ? 296 ILE A CG2 1 
ATOM   2046 C CD1 . ILE A 1 296 ? 125.518 102.927 126.207 1.00 44.62  ? 296 ILE A CD1 1 
ATOM   2047 N N   . PHE A 1 297 ? 122.900 99.858  122.357 1.00 45.21  ? 297 PHE A N   1 
ATOM   2048 C CA  . PHE A 1 297 ? 122.849 98.760  121.400 1.00 45.21  ? 297 PHE A CA  1 
ATOM   2049 C C   . PHE A 1 297 ? 122.009 99.125  120.185 1.00 45.21  ? 297 PHE A C   1 
ATOM   2050 O O   . PHE A 1 297 ? 122.433 98.920  119.043 1.00 45.21  ? 297 PHE A O   1 
ATOM   2051 C CB  . PHE A 1 297 ? 122.298 97.508  122.077 1.00 45.21  ? 297 PHE A CB  1 
ATOM   2052 C CG  . PHE A 1 297 ? 121.830 96.456  121.117 1.00 45.21  ? 297 PHE A CG  1 
ATOM   2053 C CD1 . PHE A 1 297 ? 122.726 95.810  120.285 1.00 45.21  ? 297 PHE A CD1 1 
ATOM   2054 C CD2 . PHE A 1 297 ? 120.492 96.108  121.050 1.00 45.21  ? 297 PHE A CD2 1 
ATOM   2055 C CE1 . PHE A 1 297 ? 122.298 94.837  119.404 1.00 45.21  ? 297 PHE A CE1 1 
ATOM   2056 C CE2 . PHE A 1 297 ? 120.057 95.137  120.169 1.00 45.21  ? 297 PHE A CE2 1 
ATOM   2057 C CZ  . PHE A 1 297 ? 120.962 94.502  119.345 1.00 45.21  ? 297 PHE A CZ  1 
ATOM   2058 N N   . VAL A 1 298 ? 120.818 99.685  120.411 1.00 44.33  ? 298 VAL A N   1 
ATOM   2059 C CA  . VAL A 1 298 ? 119.921 100.006 119.307 1.00 44.33  ? 298 VAL A CA  1 
ATOM   2060 C C   . VAL A 1 298 ? 120.552 101.047 118.396 1.00 44.33  ? 298 VAL A C   1 
ATOM   2061 O O   . VAL A 1 298 ? 120.580 100.883 117.172 1.00 44.33  ? 298 VAL A O   1 
ATOM   2062 C CB  . VAL A 1 298 ? 118.558 100.477 119.842 1.00 44.33  ? 298 VAL A CB  1 
ATOM   2063 C CG1 . VAL A 1 298 ? 117.800 101.234 118.768 1.00 44.33  ? 298 VAL A CG1 1 
ATOM   2064 C CG2 . VAL A 1 298 ? 117.744 99.293  120.329 1.00 44.33  ? 298 VAL A CG2 1 
ATOM   2065 N N   . CYS A 1 299 ? 121.093 102.120 118.977 1.00 43.67  ? 299 CYS A N   1 
ATOM   2066 C CA  . CYS A 1 299 ? 121.665 103.182 118.154 1.00 43.67  ? 299 CYS A CA  1 
ATOM   2067 C C   . CYS A 1 299 ? 122.847 102.670 117.341 1.00 43.67  ? 299 CYS A C   1 
ATOM   2068 O O   . CYS A 1 299 ? 122.908 102.865 116.118 1.00 43.67  ? 299 CYS A O   1 
ATOM   2069 C CB  . CYS A 1 299 ? 122.080 104.359 119.033 1.00 43.67  ? 299 CYS A CB  1 
ATOM   2070 S SG  . CYS A 1 299 ? 120.699 105.306 119.705 1.00 43.67  ? 299 CYS A SG  1 
ATOM   2071 N N   . THR A 1 300 ? 123.792 101.996 118.001 1.00 42.59  ? 300 THR A N   1 
ATOM   2072 C CA  . THR A 1 300 ? 124.989 101.537 117.307 1.00 42.59  ? 300 THR A CA  1 
ATOM   2073 C C   . THR A 1 300 ? 124.656 100.500 116.241 1.00 42.59  ? 300 THR A C   1 
ATOM   2074 O O   . THR A 1 300 ? 125.170 100.567 115.116 1.00 42.59  ? 300 THR A O   1 
ATOM   2075 C CB  . THR A 1 300 ? 125.979 100.974 118.317 1.00 42.59  ? 300 THR A CB  1 
ATOM   2076 O OG1 . THR A 1 300 ? 125.314 100.011 119.141 1.00 42.59  ? 300 THR A OG1 1 
ATOM   2077 C CG2 . THR A 1 300 ? 126.500 102.083 119.194 1.00 42.59  ? 300 THR A CG2 1 
ATOM   2078 N N   . THR A 1 301 ? 123.801 99.530  116.575 1.00 41.99  ? 301 THR A N   1 
ATOM   2079 C CA  . THR A 1 301 ? 123.439 98.501  115.613 1.00 41.99  ? 301 THR A CA  1 
ATOM   2080 C C   . THR A 1 301 ? 122.688 99.096  114.434 1.00 41.99  ? 301 THR A C   1 
ATOM   2081 O O   . THR A 1 301 ? 122.926 98.710  113.287 1.00 41.99  ? 301 THR A O   1 
ATOM   2082 C CB  . THR A 1 301 ? 122.608 97.417  116.294 1.00 41.99  ? 301 THR A CB  1 
ATOM   2083 O OG1 . THR A 1 301 ? 123.388 96.801  117.324 1.00 41.99  ? 301 THR A OG1 1 
ATOM   2084 C CG2 . THR A 1 301 ? 122.182 96.358  115.293 1.00 41.99  ? 301 THR A CG2 1 
ATOM   2085 N N   . THR A 1 302 ? 121.780 100.041 114.689 1.00 41.85  ? 302 THR A N   1 
ATOM   2086 C CA  . THR A 1 302 ? 121.050 100.672 113.599 1.00 41.85  ? 302 THR A CA  1 
ATOM   2087 C C   . THR A 1 302 ? 121.999 101.403 112.662 1.00 41.85  ? 302 THR A C   1 
ATOM   2088 O O   . THR A 1 302 ? 121.904 101.267 111.437 1.00 41.85  ? 302 THR A O   1 
ATOM   2089 C CB  . THR A 1 302 ? 120.001 101.630 114.160 1.00 41.85  ? 302 THR A CB  1 
ATOM   2090 O OG1 . THR A 1 302 ? 119.309 100.999 115.243 1.00 41.85  ? 302 THR A OG1 1 
ATOM   2091 C CG2 . THR A 1 302 ? 119.004 102.013 113.085 1.00 41.85  ? 302 THR A CG2 1 
ATOM   2092 N N   . ILE A 1 303 ? 122.939 102.169 113.221 1.00 42.39  ? 303 ILE A N   1 
ATOM   2093 C CA  . ILE A 1 303 ? 123.882 102.902 112.379 1.00 42.39  ? 303 ILE A CA  1 
ATOM   2094 C C   . ILE A 1 303 ? 124.715 101.943 111.542 1.00 42.39  ? 303 ILE A C   1 
ATOM   2095 O O   . ILE A 1 303 ? 124.817 102.088 110.316 1.00 42.39  ? 303 ILE A O   1 
ATOM   2096 C CB  . ILE A 1 303 ? 124.776 103.815 113.235 1.00 42.39  ? 303 ILE A CB  1 
ATOM   2097 C CG1 . ILE A 1 303 ? 123.939 104.913 113.868 1.00 42.39  ? 303 ILE A CG1 1 
ATOM   2098 C CG2 . ILE A 1 303 ? 125.887 104.413 112.392 1.00 42.39  ? 303 ILE A CG2 1 
ATOM   2099 C CD1 . ILE A 1 303 ? 123.314 105.783 112.839 1.00 42.39  ? 303 ILE A CD1 1 
ATOM   2100 N N   . ASN A 1 304 ? 125.310 100.939 112.186 1.00 43.98  ? 304 ASN A N   1 
ATOM   2101 C CA  . ASN A 1 304 ? 126.197 100.039 111.458 1.00 43.98  ? 304 ASN A CA  1 
ATOM   2102 C C   . ASN A 1 304 ? 125.437 99.222  110.420 1.00 43.98  ? 304 ASN A C   1 
ATOM   2103 O O   . ASN A 1 304 ? 125.935 99.006  109.308 1.00 43.98  ? 304 ASN A O   1 
ATOM   2104 C CB  . ASN A 1 304 ? 126.937 99.139  112.440 1.00 43.98  ? 304 ASN A CB  1 
ATOM   2105 C CG  . ASN A 1 304 ? 127.902 99.914  113.312 1.00 43.98  ? 304 ASN A CG  1 
ATOM   2106 O OD1 . ASN A 1 304 ? 128.994 100.277 112.877 1.00 43.98  ? 304 ASN A OD1 1 
ATOM   2107 N ND2 . ASN A 1 304 ? 127.503 100.173 114.551 1.00 43.98  ? 304 ASN A ND2 1 
ATOM   2108 N N   . CYS A 1 305 ? 124.226 98.771  110.755 1.00 44.08  ? 305 CYS A N   1 
ATOM   2109 C CA  . CYS A 1 305 ? 123.424 98.014  109.803 1.00 44.08  ? 305 CYS A CA  1 
ATOM   2110 C C   . CYS A 1 305 ? 123.036 98.874  108.609 1.00 44.08  ? 305 CYS A C   1 
ATOM   2111 O O   . CYS A 1 305 ? 123.189 98.454  107.458 1.00 44.08  ? 305 CYS A O   1 
ATOM   2112 C CB  . CYS A 1 305 ? 122.184 97.455  110.496 1.00 44.08  ? 305 CYS A CB  1 
ATOM   2113 S SG  . CYS A 1 305 ? 122.499 96.025  111.550 1.00 44.08  ? 305 CYS A SG  1 
ATOM   2114 N N   . PHE A 1 306 ? 122.562 100.096 108.859 1.00 42.36  ? 306 PHE A N   1 
ATOM   2115 C CA  . PHE A 1 306 ? 122.212 100.982 107.755 1.00 42.36  ? 306 PHE A CA  1 
ATOM   2116 C C   . PHE A 1 306 ? 123.415 101.252 106.866 1.00 42.36  ? 306 PHE A C   1 
ATOM   2117 O O   . PHE A 1 306 ? 123.282 101.347 105.640 1.00 42.36  ? 306 PHE A O   1 
ATOM   2118 C CB  . PHE A 1 306 ? 121.639 102.292 108.294 1.00 42.36  ? 306 PHE A CB  1 
ATOM   2119 C CG  . PHE A 1 306 ? 120.139 102.335 108.307 1.00 42.36  ? 306 PHE A CG  1 
ATOM   2120 C CD1 . PHE A 1 306 ? 119.427 102.435 107.127 1.00 42.36  ? 306 PHE A CD1 1 
ATOM   2121 C CD2 . PHE A 1 306 ? 119.442 102.272 109.499 1.00 42.36  ? 306 PHE A CD2 1 
ATOM   2122 C CE1 . PHE A 1 306 ? 118.051 102.471 107.137 1.00 42.36  ? 306 PHE A CE1 1 
ATOM   2123 C CE2 . PHE A 1 306 ? 118.068 102.308 109.514 1.00 42.36  ? 306 PHE A CE2 1 
ATOM   2124 C CZ  . PHE A 1 306 ? 117.371 102.408 108.332 1.00 42.36  ? 306 PHE A CZ  1 
ATOM   2125 N N   . ILE A 1 307 ? 124.600 101.378 107.462 1.00 43.00  ? 307 ILE A N   1 
ATOM   2126 C CA  . ILE A 1 307 ? 125.788 101.663 106.666 1.00 43.00  ? 307 ILE A CA  1 
ATOM   2127 C C   . ILE A 1 307 ? 126.189 100.455 105.826 1.00 43.00  ? 307 ILE A C   1 
ATOM   2128 O O   . ILE A 1 307 ? 126.523 100.593 104.643 1.00 43.00  ? 307 ILE A O   1 
ATOM   2129 C CB  . ILE A 1 307 ? 126.938 102.133 107.573 1.00 43.00  ? 307 ILE A CB  1 
ATOM   2130 C CG1 . ILE A 1 307 ? 126.615 103.499 108.170 1.00 43.00  ? 307 ILE A CG1 1 
ATOM   2131 C CG2 . ILE A 1 307 ? 128.236 102.203 106.793 1.00 43.00  ? 307 ILE A CG2 1 
ATOM   2132 C CD1 . ILE A 1 307 ? 127.641 103.984 109.162 1.00 43.00  ? 307 ILE A CD1 1 
ATOM   2133 N N   . PHE A 1 308 ? 126.154 99.254  106.407 1.00 45.01  ? 308 PHE A N   1 
ATOM   2134 C CA  . PHE A 1 308 ? 126.841 98.119  105.801 1.00 45.01  ? 308 PHE A CA  1 
ATOM   2135 C C   . PHE A 1 308 ? 125.936 97.113  105.102 1.00 45.01  ? 308 PHE A C   1 
ATOM   2136 O O   . PHE A 1 308 ? 126.412 96.409  104.207 1.00 45.01  ? 308 PHE A O   1 
ATOM   2137 C CB  . PHE A 1 308 ? 127.664 97.388  106.863 1.00 45.01  ? 308 PHE A CB  1 
ATOM   2138 C CG  . PHE A 1 308 ? 128.888 98.138  107.289 1.00 45.01  ? 308 PHE A CG  1 
ATOM   2139 C CD1 . PHE A 1 308 ? 129.957 98.289  106.424 1.00 45.01  ? 308 PHE A CD1 1 
ATOM   2140 C CD2 . PHE A 1 308 ? 128.964 98.708  108.545 1.00 45.01  ? 308 PHE A CD2 1 
ATOM   2141 C CE1 . PHE A 1 308 ? 131.081 98.983  106.810 1.00 45.01  ? 308 PHE A CE1 1 
ATOM   2142 C CE2 . PHE A 1 308 ? 130.084 99.405  108.933 1.00 45.01  ? 308 PHE A CE2 1 
ATOM   2143 C CZ  . PHE A 1 308 ? 131.143 99.541  108.066 1.00 45.01  ? 308 PHE A CZ  1 
ATOM   2144 N N   . ILE A 1 309 ? 124.661 96.998  105.480 1.00 45.75  ? 309 ILE A N   1 
ATOM   2145 C CA  . ILE A 1 309 ? 123.798 95.990  104.863 1.00 45.75  ? 309 ILE A CA  1 
ATOM   2146 C C   . ILE A 1 309 ? 123.626 96.216  103.365 1.00 45.75  ? 309 ILE A C   1 
ATOM   2147 O O   . ILE A 1 309 ? 123.724 95.240  102.603 1.00 45.75  ? 309 ILE A O   1 
ATOM   2148 C CB  . ILE A 1 309 ? 122.456 95.910  105.616 1.00 45.75  ? 309 ILE A CB  1 
ATOM   2149 C CG1 . ILE A 1 309 ? 122.659 95.300  107.001 1.00 45.75  ? 309 ILE A CG1 1 
ATOM   2150 C CG2 . ILE A 1 309 ? 121.448 95.091  104.828 1.00 45.75  ? 309 ILE A CG2 1 
ATOM   2151 C CD1 . ILE A 1 309 ? 123.136 93.869  106.973 1.00 45.75  ? 309 ILE A CD1 1 
ATOM   2152 N N   . PRO A 1 310 ? 123.360 97.433  102.874 1.00 45.17  ? 310 PRO A N   1 
ATOM   2153 C CA  . PRO A 1 310 ? 123.303 97.614  101.415 1.00 45.17  ? 310 PRO A CA  1 
ATOM   2154 C C   . PRO A 1 310 ? 124.597 97.247  100.717 1.00 45.17  ? 310 PRO A C   1 
ATOM   2155 O O   . PRO A 1 310 ? 124.561 96.740  99.588  1.00 45.17  ? 310 PRO A O   1 
ATOM   2156 C CB  . PRO A 1 310 ? 122.975 99.104  101.262 1.00 45.17  ? 310 PRO A CB  1 
ATOM   2157 C CG  . PRO A 1 310 ? 122.257 99.446  102.502 1.00 45.17  ? 310 PRO A CG  1 
ATOM   2158 C CD  . PRO A 1 310 ? 122.928 98.653  103.579 1.00 45.17  ? 310 PRO A CD  1 
ATOM   2159 N N   . GLN A 1 311 ? 125.742 97.486  101.357 1.00 46.89  ? 311 GLN A N   1 
ATOM   2160 C CA  . GLN A 1 311 ? 127.015 97.075  100.776 1.00 46.89  ? 311 GLN A CA  1 
ATOM   2161 C C   . GLN A 1 311 ? 127.064 95.565  100.600 1.00 46.89  ? 311 GLN A C   1 
ATOM   2162 O O   . GLN A 1 311 ? 127.484 95.064  99.551  1.00 46.89  ? 311 GLN A O   1 
ATOM   2163 C CB  . GLN A 1 311 ? 128.172 97.549  101.654 1.00 46.89  ? 311 GLN A CB  1 
ATOM   2164 C CG  . GLN A 1 311 ? 128.464 99.030  101.557 1.00 46.89  ? 311 GLN A CG  1 
ATOM   2165 C CD  . GLN A 1 311 ? 129.228 99.545  102.759 1.00 46.89  ? 311 GLN A CD  1 
ATOM   2166 O OE1 . GLN A 1 311 ? 130.038 98.829  103.346 1.00 46.89  ? 311 GLN A OE1 1 
ATOM   2167 N NE2 . GLN A 1 311 ? 128.967 100.791 103.137 1.00 46.89  ? 311 GLN A NE2 1 
ATOM   2168 N N   . LEU A 1 312 ? 126.636 94.823  101.624 1.00 48.20  ? 312 LEU A N   1 
ATOM   2169 C CA  . LEU A 1 312 ? 126.596 93.370  101.517 1.00 48.20  ? 312 LEU A CA  1 
ATOM   2170 C C   . LEU A 1 312 ? 125.639 92.930  100.423 1.00 48.20  ? 312 LEU A C   1 
ATOM   2171 O O   . LEU A 1 312 ? 125.947 92.013  99.652  1.00 48.20  ? 312 LEU A O   1 
ATOM   2172 C CB  . LEU A 1 312 ? 126.190 92.752  102.852 1.00 48.20  ? 312 LEU A CB  1 
ATOM   2173 C CG  . LEU A 1 312 ? 127.109 92.998  104.042 1.00 48.20  ? 312 LEU A CG  1 
ATOM   2174 C CD1 . LEU A 1 312 ? 126.296 93.001  105.313 1.00 48.20  ? 312 LEU A CD1 1 
ATOM   2175 C CD2 . LEU A 1 312 ? 128.192 91.940  104.103 1.00 48.20  ? 312 LEU A CD2 1 
ATOM   2176 N N   . LYS A 1 313 ? 124.471 93.567  100.343 1.00 50.21  ? 313 LYS A N   1 
ATOM   2177 C CA  . LYS A 1 313 ? 123.500 93.188  99.324  1.00 50.21  ? 313 LYS A CA  1 
ATOM   2178 C C   . LYS A 1 313 ? 124.065 93.392  97.925  1.00 50.21  ? 313 LYS A C   1 
ATOM   2179 O O   . LYS A 1 313 ? 123.934 92.518  97.061  1.00 50.21  ? 313 LYS A O   1 
ATOM   2180 C CB  . LYS A 1 313 ? 122.211 93.989  99.501  1.00 50.21  ? 313 LYS A CB  1 
ATOM   2181 C CG  . LYS A 1 313 ? 121.520 93.773  100.829 1.00 50.21  ? 313 LYS A CG  1 
ATOM   2182 C CD  . LYS A 1 313 ? 120.411 94.787  101.033 1.00 50.21  ? 313 LYS A CD  1 
ATOM   2183 C CE  . LYS A 1 313 ? 119.306 94.607  100.006 1.00 50.21  ? 313 LYS A CE  1 
ATOM   2184 N NZ  . LYS A 1 313 ? 118.567 93.329  100.204 1.00 50.21  ? 313 LYS A NZ  1 
ATOM   2185 N N   . GLN A 1 314 ? 124.722 94.528  97.689  1.00 54.25  ? 314 GLN A N   1 
ATOM   2186 C CA  . GLN A 1 314 ? 125.231 94.801  96.350  1.00 54.25  ? 314 GLN A CA  1 
ATOM   2187 C C   . GLN A 1 314 ? 126.459 93.961  96.028  1.00 54.25  ? 314 GLN A C   1 
ATOM   2188 O O   . GLN A 1 314 ? 126.649 93.567  94.871  1.00 54.25  ? 314 GLN A O   1 
ATOM   2189 C CB  . GLN A 1 314 ? 125.539 96.290  96.200  1.00 54.25  ? 314 GLN A CB  1 
ATOM   2190 C CG  . GLN A 1 314 ? 124.315 97.133  95.883  1.00 54.25  ? 314 GLN A CG  1 
ATOM   2191 C CD  . GLN A 1 314 ? 124.644 98.601  95.705  1.00 54.25  ? 314 GLN A CD  1 
ATOM   2192 O OE1 . GLN A 1 314 ? 125.713 99.062  96.101  1.00 54.25  ? 314 GLN A OE1 1 
ATOM   2193 N NE2 . GLN A 1 314 ? 123.723 99.344  95.101  1.00 54.25  ? 314 GLN A NE2 1 
ATOM   2194 N N   . TRP A 1 315 ? 127.294 93.661  97.024  1.00 57.07  ? 315 TRP A N   1 
ATOM   2195 C CA  . TRP A 1 315 ? 128.400 92.735  96.802  1.00 57.07  ? 315 TRP A CA  1 
ATOM   2196 C C   . TRP A 1 315 ? 127.885 91.351  96.428  1.00 57.07  ? 315 TRP A C   1 
ATOM   2197 O O   . TRP A 1 315 ? 128.391 90.718  95.495  1.00 57.07  ? 315 TRP A O   1 
ATOM   2198 C CB  . TRP A 1 315 ? 129.284 92.665  98.045  1.00 57.07  ? 315 TRP A CB  1 
ATOM   2199 C CG  . TRP A 1 315 ? 130.241 91.520  98.024  1.00 57.07  ? 315 TRP A CG  1 
ATOM   2200 C CD1 . TRP A 1 315 ? 131.089 91.180  97.013  1.00 57.07  ? 315 TRP A CD1 1 
ATOM   2201 C CD2 . TRP A 1 315 ? 130.443 90.552  99.060  1.00 57.07  ? 315 TRP A CD2 1 
ATOM   2202 N NE1 . TRP A 1 315 ? 131.811 90.064  97.356  1.00 57.07  ? 315 TRP A NE1 1 
ATOM   2203 C CE2 . TRP A 1 315 ? 131.434 89.658  98.608  1.00 57.07  ? 315 TRP A CE2 1 
ATOM   2204 C CE3 . TRP A 1 315 ? 129.885 90.356  100.327 1.00 57.07  ? 315 TRP A CE3 1 
ATOM   2205 C CZ2 . TRP A 1 315 ? 131.878 88.585  99.378  1.00 57.07  ? 315 TRP A CZ2 1 
ATOM   2206 C CZ3 . TRP A 1 315 ? 130.327 89.290  101.090 1.00 57.07  ? 315 TRP A CZ3 1 
ATOM   2207 C CH2 . TRP A 1 315 ? 131.314 88.418  100.612 1.00 57.07  ? 315 TRP A CH2 1 
ATOM   2208 N N   . LYS A 1 316 ? 126.876 90.861  97.153  1.00 60.10  ? 316 LYS A N   1 
ATOM   2209 C CA  . LYS A 1 316 ? 126.293 89.564  96.830  1.00 60.10  ? 316 LYS A CA  1 
ATOM   2210 C C   . LYS A 1 316 ? 125.653 89.582  95.449  1.00 60.10  ? 316 LYS A C   1 
ATOM   2211 O O   . LYS A 1 316 ? 125.725 88.593  94.709  1.00 60.10  ? 316 LYS A O   1 
ATOM   2212 C CB  . LYS A 1 316 ? 125.270 89.169  97.895  1.00 60.10  ? 316 LYS A CB  1 
ATOM   2213 C CG  . LYS A 1 316 ? 124.737 87.753  97.751  1.00 60.10  ? 316 LYS A CG  1 
ATOM   2214 C CD  . LYS A 1 316 ? 123.760 87.416  98.866  1.00 60.10  ? 316 LYS A CD  1 
ATOM   2215 C CE  . LYS A 1 316 ? 123.352 85.953  98.818  1.00 60.10  ? 316 LYS A CE  1 
ATOM   2216 N NZ  . LYS A 1 316 ? 122.565 85.635  97.595  1.00 60.10  ? 316 LYS A NZ  1 
ATOM   2217 N N   . ALA A 1 317 ? 125.017 90.698  95.085  1.00 61.59  ? 317 ALA A N   1 
ATOM   2218 C CA  . ALA A 1 317 ? 124.481 90.836  93.737  1.00 61.59  ? 317 ALA A CA  1 
ATOM   2219 C C   . ALA A 1 317 ? 125.592 90.838  92.697  1.00 61.59  ? 317 ALA A C   1 
ATOM   2220 O O   . ALA A 1 317 ? 125.368 90.443  91.547  1.00 61.59  ? 317 ALA A O   1 
ATOM   2221 C CB  . ALA A 1 317 ? 123.646 92.112  93.629  1.00 61.59  ? 317 ALA A CB  1 
ATOM   2222 N N   . PHE A 1 318 ? 126.792 91.279  93.077  1.00 64.18  ? 318 PHE A N   1 
ATOM   2223 C CA  . PHE A 1 318 ? 127.927 91.218  92.162  1.00 64.18  ? 318 PHE A CA  1 
ATOM   2224 C C   . PHE A 1 318 ? 128.358 89.776  91.928  1.00 64.18  ? 318 PHE A C   1 
ATOM   2225 O O   . PHE A 1 318 ? 128.518 89.339  90.782  1.00 64.18  ? 318 PHE A O   1 
ATOM   2226 C CB  . PHE A 1 318 ? 129.089 92.046  92.711  1.00 64.18  ? 318 PHE A CB  1 
ATOM   2227 C CG  . PHE A 1 318 ? 130.405 91.756  92.048  1.00 64.18  ? 318 PHE A CG  1 
ATOM   2228 C CD1 . PHE A 1 318 ? 130.677 92.237  90.778  1.00 64.18  ? 318 PHE A CD1 1 
ATOM   2229 C CD2 . PHE A 1 318 ? 131.369 91.001  92.695  1.00 64.18  ? 318 PHE A CD2 1 
ATOM   2230 C CE1 . PHE A 1 318 ? 131.887 91.971  90.166  1.00 64.18  ? 318 PHE A CE1 1 
ATOM   2231 C CE2 . PHE A 1 318 ? 132.581 90.732  92.089  1.00 64.18  ? 318 PHE A CE2 1 
ATOM   2232 C CZ  . PHE A 1 318 ? 132.840 91.218  90.822  1.00 64.18  ? 318 PHE A CZ  1 
ATOM   2233 N N   . GLU A 1 319 ? 128.549 89.019  93.004  1.00 66.91  ? 319 GLU A N   1 
ATOM   2234 C CA  . GLU A 1 319 ? 128.939 87.617  92.898  1.00 66.91  ? 319 GLU A CA  1 
ATOM   2235 C C   . GLU A 1 319 ? 128.587 86.851  94.170  1.00 66.91  ? 319 GLU A C   1 
ATOM   2236 O O   . GLU A 1 319 ? 128.359 87.447  95.222  1.00 66.91  ? 319 GLU A O   1 
ATOM   2237 C CB  . GLU A 1 319 ? 130.436 87.494  92.608  1.00 66.91  ? 319 GLU A CB  1 
ATOM   2238 C CG  . GLU A 1 319 ? 130.876 86.096  92.203  1.00 66.91  ? 319 GLU A CG  1 
ATOM   2239 C CD  . GLU A 1 319 ? 130.405 85.716  90.812  1.00 66.91  ? 319 GLU A CD  1 
ATOM   2240 O OE1 . GLU A 1 319 ? 130.201 86.626  89.981  1.00 66.91  ? 319 GLU A OE1 1 
ATOM   2241 O OE2 . GLU A 1 319 ? 130.238 84.506  90.550  1.00 66.91  ? 319 GLU A OE2 1 
ATOM   2242 N N   . ARG B 1 22  ? 118.139 107.746 163.020 1.00 143.04 ? 22  ARG B N   1 
ATOM   2243 C CA  . ARG B 1 22  ? 117.338 107.845 164.237 1.00 143.04 ? 22  ARG B CA  1 
ATOM   2244 C C   . ARG B 1 22  ? 117.786 108.981 165.176 1.00 143.04 ? 22  ARG B C   1 
ATOM   2245 O O   . ARG B 1 22  ? 116.946 109.766 165.615 1.00 143.04 ? 22  ARG B O   1 
ATOM   2246 C CB  . ARG B 1 22  ? 117.339 106.506 164.988 1.00 143.04 ? 22  ARG B CB  1 
ATOM   2247 N N   . PRO B 1 23  ? 119.082 109.072 165.510 1.00 141.94 ? 23  PRO B N   1 
ATOM   2248 C CA  . PRO B 1 23  ? 119.511 110.187 166.373 1.00 141.94 ? 23  PRO B CA  1 
ATOM   2249 C C   . PRO B 1 23  ? 119.273 111.555 165.759 1.00 141.94 ? 23  PRO B C   1 
ATOM   2250 O O   . PRO B 1 23  ? 118.976 112.509 166.490 1.00 141.94 ? 23  PRO B O   1 
ATOM   2251 C CB  . PRO B 1 23  ? 121.007 109.914 166.584 1.00 141.94 ? 23  PRO B CB  1 
ATOM   2252 N N   . LEU B 1 24  ? 119.394 111.683 164.435 1.00 140.15 ? 24  LEU B N   1 
ATOM   2253 C CA  . LEU B 1 24  ? 119.129 112.966 163.793 1.00 140.15 ? 24  LEU B CA  1 
ATOM   2254 C C   . LEU B 1 24  ? 117.639 113.279 163.734 1.00 140.15 ? 24  LEU B C   1 
ATOM   2255 O O   . LEU B 1 24  ? 117.262 114.455 163.730 1.00 140.15 ? 24  LEU B O   1 
ATOM   2256 C CB  . LEU B 1 24  ? 119.732 112.981 162.388 1.00 140.15 ? 24  LEU B CB  1 
ATOM   2257 N N   . HIS B 1 25  ? 116.794 112.252 163.613 1.00 141.17 ? 25  HIS B N   1 
ATOM   2258 C CA  . HIS B 1 25  ? 115.340 112.396 163.627 1.00 141.17 ? 25  HIS B CA  1 
ATOM   2259 C C   . HIS B 1 25  ? 114.822 113.365 164.691 1.00 141.17 ? 25  HIS B C   1 
ATOM   2260 O O   . HIS B 1 25  ? 114.086 114.313 164.387 1.00 141.17 ? 25  HIS B O   1 
ATOM   2261 C CB  . HIS B 1 25  ? 114.694 111.018 163.809 1.00 141.17 ? 25  HIS B CB  1 
ATOM   2262 N N   . ASP B 1 26  ? 115.180 113.113 165.955 1.00 142.57 ? 26  ASP B N   1 
ATOM   2263 C CA  . ASP B 1 26  ? 114.745 113.981 167.047 1.00 142.57 ? 26  ASP B CA  1 
ATOM   2264 C C   . ASP B 1 26  ? 115.250 115.409 166.879 1.00 142.57 ? 26  ASP B C   1 
ATOM   2265 O O   . ASP B 1 26  ? 114.511 116.368 167.134 1.00 142.57 ? 26  ASP B O   1 
ATOM   2266 C CB  . ASP B 1 26  ? 115.210 113.406 168.385 1.00 142.57 ? 26  ASP B CB  1 
ATOM   2267 N N   . LEU B 1 27  ? 116.510 115.574 166.468 1.00 141.35 ? 27  LEU B N   1 
ATOM   2268 C CA  . LEU B 1 27  ? 117.039 116.921 166.285 1.00 141.35 ? 27  LEU B CA  1 
ATOM   2269 C C   . LEU B 1 27  ? 116.267 117.661 165.202 1.00 141.35 ? 27  LEU B C   1 
ATOM   2270 O O   . LEU B 1 27  ? 115.953 118.849 165.349 1.00 141.35 ? 27  LEU B O   1 
ATOM   2271 C CB  . LEU B 1 27  ? 118.527 116.860 165.943 1.00 141.35 ? 27  LEU B CB  1 
ATOM   2272 N N   . CYS B 1 28  ? 115.951 116.972 164.103 1.00 138.54 ? 28  CYS B N   1 
ATOM   2273 C CA  . CYS B 1 28  ? 115.206 117.606 163.024 1.00 138.54 ? 28  CYS B CA  1 
ATOM   2274 C C   . CYS B 1 28  ? 113.795 117.955 163.471 1.00 138.54 ? 28  CYS B C   1 
ATOM   2275 O O   . CYS B 1 28  ? 113.259 119.004 163.094 1.00 138.54 ? 28  CYS B O   1 
ATOM   2276 C CB  . CYS B 1 28  ? 115.171 116.691 161.801 1.00 138.54 ? 28  CYS B CB  1 
ATOM   2277 N N   . LYS B 1 29  ? 113.172 117.084 164.270 1.00 139.64 ? 29  LYS B N   1 
ATOM   2278 C CA  . LYS B 1 29  ? 111.843 117.396 164.783 1.00 139.64 ? 29  LYS B CA  1 
ATOM   2279 C C   . LYS B 1 29  ? 111.885 118.636 165.665 1.00 139.64 ? 29  LYS B C   1 
ATOM   2280 O O   . LYS B 1 29  ? 111.006 119.502 165.577 1.00 139.64 ? 29  LYS B O   1 
ATOM   2281 C CB  . LYS B 1 29  ? 111.281 116.201 165.553 1.00 139.64 ? 29  LYS B CB  1 
ATOM   2282 N N   . THR B 1 30  ? 112.900 118.731 166.530 1.00 142.30 ? 30  THR B N   1 
ATOM   2283 C CA  . THR B 1 30  ? 113.034 119.900 167.394 1.00 142.30 ? 30  THR B CA  1 
ATOM   2284 C C   . THR B 1 30  ? 113.257 121.161 166.570 1.00 142.30 ? 30  THR B C   1 
ATOM   2285 O O   . THR B 1 30  ? 112.712 122.227 166.881 1.00 142.30 ? 30  THR B O   1 
ATOM   2286 C CB  . THR B 1 30  ? 114.179 119.697 168.386 1.00 142.30 ? 30  THR B CB  1 
ATOM   2287 N N   . THR B 1 31  ? 114.065 121.051 165.512 1.00 139.65 ? 31  THR B N   1 
ATOM   2288 C CA  . THR B 1 31  ? 114.338 122.187 164.637 1.00 139.65 ? 31  THR B CA  1 
ATOM   2289 C C   . THR B 1 31  ? 113.071 122.674 163.945 1.00 139.65 ? 31  THR B C   1 
ATOM   2290 O O   . THR B 1 31  ? 112.843 123.885 163.835 1.00 139.65 ? 31  THR B O   1 
ATOM   2291 C CB  . THR B 1 31  ? 115.405 121.813 163.608 1.00 139.65 ? 31  THR B CB  1 
ATOM   2292 N N   . ILE B 1 32  ? 112.243 121.746 163.456 1.00 139.33 ? 32  ILE B N   1 
ATOM   2293 C CA  . ILE B 1 32  ? 110.996 122.128 162.797 1.00 139.33 ? 32  ILE B CA  1 
ATOM   2294 C C   . ILE B 1 32  ? 110.103 122.901 163.756 1.00 139.33 ? 32  ILE B C   1 
ATOM   2295 O O   . ILE B 1 32  ? 109.468 123.891 163.373 1.00 139.33 ? 32  ILE B O   1 
ATOM   2296 C CB  . ILE B 1 32  ? 110.283 120.884 162.236 1.00 139.33 ? 32  ILE B CB  1 
ATOM   2297 N N   . THR B 1 33  ? 110.032 122.462 165.014 1.00 141.38 ? 33  THR B N   1 
ATOM   2298 C CA  . THR B 1 33  ? 109.254 123.210 165.995 1.00 141.38 ? 33  THR B CA  1 
ATOM   2299 C C   . THR B 1 33  ? 109.898 124.563 166.269 1.00 141.38 ? 33  THR B C   1 
ATOM   2300 O O   . THR B 1 33  ? 109.199 125.569 166.442 1.00 141.38 ? 33  THR B O   1 
ATOM   2301 C CB  . THR B 1 33  ? 109.118 122.406 167.288 1.00 141.38 ? 33  THR B CB  1 
ATOM   2302 N N   . SER B 1 34  ? 111.224 124.614 166.245 1.00 140.87 ? 34  SER B N   1 
ATOM   2303 C CA  . SER B 1 34  ? 111.915 125.884 166.438 1.00 140.87 ? 34  SER B CA  1 
ATOM   2304 C C   . SER B 1 34  ? 111.809 126.774 165.200 1.00 140.87 ? 34  SER B C   1 
ATOM   2305 O O   . SER B 1 34  ? 112.625 127.675 165.010 1.00 140.87 ? 34  SER B O   1 
ATOM   2306 C CB  . SER B 1 34  ? 113.385 125.643 166.788 1.00 140.87 ? 34  SER B CB  1 
ATOM   2307 N N   . SER B 1 35  ? 110.809 126.528 164.358 1.00 139.44 ? 35  SER B N   1 
ATOM   2308 C CA  . SER B 1 35  ? 110.648 127.310 163.129 1.00 139.44 ? 35  SER B CA  1 
ATOM   2309 C C   . SER B 1 35  ? 110.313 128.772 163.401 1.00 139.44 ? 35  SER B C   1 
ATOM   2310 O O   . SER B 1 35  ? 110.913 129.668 162.808 1.00 139.44 ? 35  SER B O   1 
ATOM   2311 C CB  . SER B 1 35  ? 109.563 126.693 162.246 1.00 139.44 ? 35  SER B CB  1 
ATOM   2312 N N   . HIS B 1 36  ? 109.352 129.016 164.286 1.00 137.98 ? 36  HIS B N   1 
ATOM   2313 C CA  . HIS B 1 36  ? 108.976 130.388 164.637 1.00 137.98 ? 36  HIS B CA  1 
ATOM   2314 C C   . HIS B 1 36  ? 108.625 131.248 163.422 1.00 137.98 ? 36  HIS B C   1 
ATOM   2315 O O   . HIS B 1 36  ? 109.058 132.397 163.331 1.00 137.98 ? 36  HIS B O   1 
ATOM   2316 C CB  . HIS B 1 36  ? 110.094 131.055 165.445 1.00 137.98 ? 36  HIS B CB  1 
ATOM   2317 N N   . HIS B 1 37  ? 107.839 130.705 162.497 1.00 134.84 ? 37  HIS B N   1 
ATOM   2318 C CA  . HIS B 1 37  ? 107.413 131.479 161.328 1.00 134.84 ? 37  HIS B CA  1 
ATOM   2319 C C   . HIS B 1 37  ? 108.547 131.680 160.335 1.00 134.84 ? 37  HIS B C   1 
ATOM   2320 O O   . HIS B 1 37  ? 108.298 131.885 159.147 1.00 134.84 ? 37  HIS B O   1 
ATOM   2321 C CB  . HIS B 1 37  ? 106.851 132.834 161.763 1.00 134.84 ? 37  HIS B CB  1 
ATOM   2322 N N   . SER B 1 38  ? 109.785 131.640 160.814 1.00 128.41 ? 38  SER B N   1 
ATOM   2323 C CA  . SER B 1 38  ? 110.945 131.776 159.938 1.00 128.41 ? 38  SER B CA  1 
ATOM   2324 C C   . SER B 1 38  ? 110.953 133.142 159.261 1.00 128.41 ? 38  SER B C   1 
ATOM   2325 O O   . SER B 1 38  ? 110.606 134.149 159.887 1.00 128.41 ? 38  SER B O   1 
ATOM   2326 C CB  . SER B 1 38  ? 110.975 130.656 158.894 1.00 128.41 ? 38  SER B CB  1 
ATOM   2327 N N   . SER B 1 39  ? 111.337 133.189 157.987 1.00 114.25 ? 39  SER B N   1 
ATOM   2328 C CA  . SER B 1 39  ? 111.409 134.450 157.262 1.00 114.25 ? 39  SER B CA  1 
ATOM   2329 C C   . SER B 1 39  ? 111.453 134.163 155.767 1.00 114.25 ? 39  SER B C   1 
ATOM   2330 O O   . SER B 1 39  ? 111.688 133.031 155.336 1.00 114.25 ? 39  SER B O   1 
ATOM   2331 C CB  . SER B 1 39  ? 112.626 135.275 157.693 1.00 114.25 ? 39  SER B CB  1 
ATOM   2332 N N   . LYS B 1 40  ? 111.221 135.213 154.982 1.00 104.98 ? 40  LYS B N   1 
ATOM   2333 C CA  . LYS B 1 40  ? 111.261 135.142 153.529 1.00 104.98 ? 40  LYS B CA  1 
ATOM   2334 C C   . LYS B 1 40  ? 112.109 136.287 152.995 1.00 104.98 ? 40  LYS B C   1 
ATOM   2335 O O   . LYS B 1 40  ? 112.228 137.340 153.628 1.00 104.98 ? 40  LYS B O   1 
ATOM   2336 C CB  . LYS B 1 40  ? 109.853 135.202 152.920 1.00 104.98 ? 40  LYS B CB  1 
ATOM   2337 N N   . THR B 1 41  ? 112.699 136.073 151.821 1.00 100.39 ? 41  THR B N   1 
ATOM   2338 C CA  . THR B 1 41  ? 113.593 137.042 151.201 1.00 100.39 ? 41  THR B CA  1 
ATOM   2339 C C   . THR B 1 41  ? 113.082 137.400 149.814 1.00 100.39 ? 41  THR B C   1 
ATOM   2340 O O   . THR B 1 41  ? 112.762 136.513 149.016 1.00 100.39 ? 41  THR B O   1 
ATOM   2341 C CB  . THR B 1 41  ? 115.021 136.495 151.109 1.00 100.39 ? 41  THR B CB  1 
ATOM   2342 N N   . ILE B 1 42  ? 113.008 138.703 149.532 1.00 92.68  ? 42  ILE B N   1 
ATOM   2343 C CA  . ILE B 1 42  ? 112.597 139.210 148.230 1.00 92.68  ? 42  ILE B CA  1 
ATOM   2344 C C   . ILE B 1 42  ? 113.503 140.375 147.856 1.00 92.68  ? 42  ILE B C   1 
ATOM   2345 O O   . ILE B 1 42  ? 114.110 141.021 148.712 1.00 92.68  ? 42  ILE B O   1 
ATOM   2346 C CB  . ILE B 1 42  ? 111.117 139.654 148.210 1.00 92.68  ? 42  ILE B CB  1 
ATOM   2347 N N   . SER B 1 43  ? 113.589 140.639 146.554 1.00 80.47  ? 43  SER B N   1 
ATOM   2348 C CA  . SER B 1 43  ? 114.433 141.712 146.050 1.00 80.47  ? 43  SER B CA  1 
ATOM   2349 C C   . SER B 1 43  ? 113.891 142.189 144.711 1.00 80.47  ? 43  SER B C   1 
ATOM   2350 O O   . SER B 1 43  ? 113.064 141.528 144.077 1.00 80.47  ? 43  SER B O   1 
ATOM   2351 C CB  . SER B 1 43  ? 115.892 141.261 145.918 1.00 80.47  ? 43  SER B CB  1 
ATOM   2352 O OG  . SER B 1 43  ? 116.706 142.308 145.416 1.00 80.47  ? 43  SER B OG  1 
ATOM   2353 N N   . SER B 1 44  ? 114.370 143.356 144.286 1.00 70.91  ? 44  SER B N   1 
ATOM   2354 C CA  . SER B 1 44  ? 113.978 143.960 143.023 1.00 70.91  ? 44  SER B CA  1 
ATOM   2355 C C   . SER B 1 44  ? 115.211 144.245 142.177 1.00 70.91  ? 44  SER B C   1 
ATOM   2356 O O   . SER B 1 44  ? 116.294 144.523 142.700 1.00 70.91  ? 44  SER B O   1 
ATOM   2357 C CB  . SER B 1 44  ? 113.189 145.256 143.248 1.00 70.91  ? 44  SER B CB  1 
ATOM   2358 O OG  . SER B 1 44  ? 111.968 144.999 143.918 1.00 70.91  ? 44  SER B OG  1 
ATOM   2359 N N   . LEU B 1 45  ? 115.037 144.171 140.861 1.00 61.28  ? 45  LEU B N   1 
ATOM   2360 C CA  . LEU B 1 45  ? 116.123 144.471 139.943 1.00 61.28  ? 45  LEU B CA  1 
ATOM   2361 C C   . LEU B 1 45  ? 116.395 145.973 139.902 1.00 61.28  ? 45  LEU B C   1 
ATOM   2362 O O   . LEU B 1 45  ? 115.576 146.795 140.324 1.00 61.28  ? 45  LEU B O   1 
ATOM   2363 C CB  . LEU B 1 45  ? 115.792 143.968 138.539 1.00 61.28  ? 45  LEU B CB  1 
ATOM   2364 C CG  . LEU B 1 45  ? 115.555 142.469 138.390 1.00 61.28  ? 45  LEU B CG  1 
ATOM   2365 C CD1 . LEU B 1 45  ? 115.140 142.151 136.969 1.00 61.28  ? 45  LEU B CD1 1 
ATOM   2366 C CD2 . LEU B 1 45  ? 116.800 141.688 138.776 1.00 61.28  ? 45  LEU B CD2 1 
ATOM   2367 N N   . SER B 1 46  ? 117.567 146.324 139.388 1.00 58.66  ? 46  SER B N   1 
ATOM   2368 C CA  . SER B 1 46  ? 117.916 147.729 139.217 1.00 58.66  ? 46  SER B CA  1 
ATOM   2369 C C   . SER B 1 46  ? 117.018 148.353 138.155 1.00 58.66  ? 46  SER B C   1 
ATOM   2370 O O   . SER B 1 46  ? 116.829 147.760 137.087 1.00 58.66  ? 46  SER B O   1 
ATOM   2371 C CB  . SER B 1 46  ? 119.380 147.870 138.817 1.00 58.66  ? 46  SER B CB  1 
ATOM   2372 O OG  . SER B 1 46  ? 119.533 147.759 137.414 1.00 58.66  ? 46  SER B OG  1 
ATOM   2373 N N   . PRO B 1 47  ? 116.450 149.540 138.400 1.00 56.84  ? 47  PRO B N   1 
ATOM   2374 C CA  . PRO B 1 47  ? 115.533 150.129 137.416 1.00 56.84  ? 47  PRO B CA  1 
ATOM   2375 C C   . PRO B 1 47  ? 116.257 150.801 136.260 1.00 56.84  ? 47  PRO B C   1 
ATOM   2376 O O   . PRO B 1 47  ? 115.885 151.897 135.831 1.00 56.84  ? 47  PRO B O   1 
ATOM   2377 C CB  . PRO B 1 47  ? 114.746 151.145 138.248 1.00 56.84  ? 47  PRO B CB  1 
ATOM   2378 C CG  . PRO B 1 47  ? 115.709 151.569 139.307 1.00 56.84  ? 47  PRO B CG  1 
ATOM   2379 C CD  . PRO B 1 47  ? 116.592 150.379 139.602 1.00 56.84  ? 47  PRO B CD  1 
ATOM   2380 N N   . VAL B 1 48  ? 117.294 150.141 135.750 1.00 54.36  ? 48  VAL B N   1 
ATOM   2381 C CA  . VAL B 1 48  ? 117.993 150.550 134.539 1.00 54.36  ? 48  VAL B CA  1 
ATOM   2382 C C   . VAL B 1 48  ? 118.026 149.418 133.521 1.00 54.36  ? 48  VAL B C   1 
ATOM   2383 O O   . VAL B 1 48  ? 117.768 149.626 132.330 1.00 54.36  ? 48  VAL B O   1 
ATOM   2384 C CB  . VAL B 1 48  ? 119.424 151.041 134.851 1.00 54.36  ? 48  VAL B CB  1 
ATOM   2385 C CG1 . VAL B 1 48  ? 120.038 151.691 133.623 1.00 54.36  ? 48  VAL B CG1 1 
ATOM   2386 C CG2 . VAL B 1 48  ? 119.420 152.005 136.025 1.00 54.36  ? 48  VAL B CG2 1 
ATOM   2387 N N   . LEU B 1 49  ? 118.355 148.207 133.976 1.00 52.68  ? 49  LEU B N   1 
ATOM   2388 C CA  . LEU B 1 49  ? 118.284 147.041 133.106 1.00 52.68  ? 49  LEU B CA  1 
ATOM   2389 C C   . LEU B 1 49  ? 116.856 146.799 132.644 1.00 52.68  ? 49  LEU B C   1 
ATOM   2390 O O   . LEU B 1 49  ? 116.625 146.431 131.487 1.00 52.68  ? 49  LEU B O   1 
ATOM   2391 C CB  . LEU B 1 49  ? 118.834 145.813 133.831 1.00 52.68  ? 49  LEU B CB  1 
ATOM   2392 C CG  . LEU B 1 49  ? 119.041 144.549 132.998 1.00 52.68  ? 49  LEU B CG  1 
ATOM   2393 C CD1 . LEU B 1 49  ? 119.612 144.887 131.633 1.00 52.68  ? 49  LEU B CD1 1 
ATOM   2394 C CD2 . LEU B 1 49  ? 119.946 143.577 133.732 1.00 52.68  ? 49  LEU B CD2 1 
ATOM   2395 N N   . LEU B 1 50  ? 115.882 147.019 133.531 1.00 54.25  ? 50  LEU B N   1 
ATOM   2396 C CA  . LEU B 1 50  ? 114.483 146.934 133.128 1.00 54.25  ? 50  LEU B CA  1 
ATOM   2397 C C   . LEU B 1 50  ? 114.177 147.917 132.008 1.00 54.25  ? 50  LEU B C   1 
ATOM   2398 O O   . LEU B 1 50  ? 113.514 147.562 131.028 1.00 54.25  ? 50  LEU B O   1 
ATOM   2399 C CB  . LEU B 1 50  ? 113.572 147.189 134.328 1.00 54.25  ? 50  LEU B CB  1 
ATOM   2400 C CG  . LEU B 1 50  ? 113.582 146.148 135.447 1.00 54.25  ? 50  LEU B CG  1 
ATOM   2401 C CD1 . LEU B 1 50  ? 112.818 146.659 136.658 1.00 54.25  ? 50  LEU B CD1 1 
ATOM   2402 C CD2 . LEU B 1 50  ? 112.994 144.834 134.962 1.00 54.25  ? 50  LEU B CD2 1 
ATOM   2403 N N   . GLY B 1 51  ? 114.664 149.152 132.128 1.00 51.78  ? 51  GLY B N   1 
ATOM   2404 C CA  . GLY B 1 51  ? 114.398 150.142 131.098 1.00 51.78  ? 51  GLY B CA  1 
ATOM   2405 C C   . GLY B 1 51  ? 115.050 149.798 129.774 1.00 51.78  ? 51  GLY B C   1 
ATOM   2406 O O   . GLY B 1 51  ? 114.436 149.945 128.713 1.00 51.78  ? 51  GLY B O   1 
ATOM   2407 N N   . ILE B 1 52  ? 116.300 149.334 129.816 1.00 52.32  ? 52  ILE B N   1 
ATOM   2408 C CA  . ILE B 1 52  ? 116.995 148.954 128.587 1.00 52.32  ? 52  ILE B CA  1 
ATOM   2409 C C   . ILE B 1 52  ? 116.290 147.782 127.914 1.00 52.32  ? 52  ILE B C   1 
ATOM   2410 O O   . ILE B 1 52  ? 116.077 147.779 126.693 1.00 52.32  ? 52  ILE B O   1 
ATOM   2411 C CB  . ILE B 1 52  ? 118.470 148.636 128.883 1.00 52.32  ? 52  ILE B CB  1 
ATOM   2412 C CG1 . ILE B 1 52  ? 119.156 149.844 129.516 1.00 52.32  ? 52  ILE B CG1 1 
ATOM   2413 C CG2 . ILE B 1 52  ? 119.191 148.230 127.611 1.00 52.32  ? 52  ILE B CG2 1 
ATOM   2414 C CD1 . ILE B 1 52  ? 119.120 151.081 128.653 1.00 52.32  ? 52  ILE B CD1 1 
ATOM   2415 N N   . VAL B 1 53  ? 115.908 146.773 128.698 1.00 53.06  ? 53  VAL B N   1 
ATOM   2416 C CA  . VAL B 1 53  ? 115.199 145.625 128.145 1.00 53.06  ? 53  VAL B CA  1 
ATOM   2417 C C   . VAL B 1 53  ? 113.875 146.056 127.532 1.00 53.06  ? 53  VAL B C   1 
ATOM   2418 O O   . VAL B 1 53  ? 113.521 145.646 126.418 1.00 53.06  ? 53  VAL B O   1 
ATOM   2419 C CB  . VAL B 1 53  ? 114.995 144.556 129.232 1.00 53.06  ? 53  VAL B CB  1 
ATOM   2420 C CG1 . VAL B 1 53  ? 114.098 143.461 128.722 1.00 53.06  ? 53  VAL B CG1 1 
ATOM   2421 C CG2 . VAL B 1 53  ? 116.336 143.967 129.634 1.00 53.06  ? 53  VAL B CG2 1 
ATOM   2422 N N   . TRP B 1 54  ? 113.125 146.895 128.249 1.00 52.73  ? 54  TRP B N   1 
ATOM   2423 C CA  . TRP B 1 54  ? 111.829 147.334 127.752 1.00 52.73  ? 54  TRP B CA  1 
ATOM   2424 C C   . TRP B 1 54  ? 111.969 148.122 126.459 1.00 52.73  ? 54  TRP B C   1 
ATOM   2425 O O   . TRP B 1 54  ? 111.210 147.899 125.513 1.00 52.73  ? 54  TRP B O   1 
ATOM   2426 C CB  . TRP B 1 54  ? 111.108 148.152 128.819 1.00 52.73  ? 54  TRP B CB  1 
ATOM   2427 C CG  . TRP B 1 54  ? 110.566 147.304 129.923 1.00 52.73  ? 54  TRP B CG  1 
ATOM   2428 C CD1 . TRP B 1 54  ? 110.450 145.947 129.928 1.00 52.73  ? 54  TRP B CD1 1 
ATOM   2429 C CD2 . TRP B 1 54  ? 110.073 147.753 131.190 1.00 52.73  ? 54  TRP B CD2 1 
ATOM   2430 N NE1 . TRP B 1 54  ? 109.912 145.521 131.116 1.00 52.73  ? 54  TRP B NE1 1 
ATOM   2431 C CE2 . TRP B 1 54  ? 109.672 146.611 131.910 1.00 52.73  ? 54  TRP B CE2 1 
ATOM   2432 C CE3 . TRP B 1 54  ? 109.930 149.010 131.786 1.00 52.73  ? 54  TRP B CE3 1 
ATOM   2433 C CZ2 . TRP B 1 54  ? 109.137 146.686 133.193 1.00 52.73  ? 54  TRP B CZ2 1 
ATOM   2434 C CZ3 . TRP B 1 54  ? 109.398 149.083 133.061 1.00 52.73  ? 54  TRP B CZ3 1 
ATOM   2435 C CH2 . TRP B 1 54  ? 109.009 147.928 133.751 1.00 52.73  ? 54  TRP B CH2 1 
ATOM   2436 N N   . THR B 1 55  ? 112.942 149.035 126.384 1.00 50.86  ? 55  THR B N   1 
ATOM   2437 C CA  . THR B 1 55  ? 113.075 149.830 125.167 1.00 50.86  ? 55  THR B CA  1 
ATOM   2438 C C   . THR B 1 55  ? 113.551 148.981 123.994 1.00 50.86  ? 55  THR B C   1 
ATOM   2439 O O   . THR B 1 55  ? 113.105 149.184 122.857 1.00 50.86  ? 55  THR B O   1 
ATOM   2440 C CB  . THR B 1 55  ? 114.003 151.031 125.387 1.00 50.86  ? 55  THR B CB  1 
ATOM   2441 O OG1 . THR B 1 55  ? 114.036 151.827 124.196 1.00 50.86  ? 55  THR B OG1 1 
ATOM   2442 C CG2 . THR B 1 55  ? 115.415 150.600 125.721 1.00 50.86  ? 55  THR B CG2 1 
ATOM   2443 N N   . PHE B 1 56  ? 114.431 148.005 124.239 1.00 50.50  ? 56  PHE B N   1 
ATOM   2444 C CA  . PHE B 1 56  ? 114.903 147.192 123.123 1.00 50.50  ? 56  PHE B CA  1 
ATOM   2445 C C   . PHE B 1 56  ? 113.805 146.271 122.608 1.00 50.50  ? 56  PHE B C   1 
ATOM   2446 O O   . PHE B 1 56  ? 113.627 146.123 121.390 1.00 50.50  ? 56  PHE B O   1 
ATOM   2447 C CB  . PHE B 1 56  ? 116.143 146.403 123.528 1.00 50.50  ? 56  PHE B CB  1 
ATOM   2448 C CG  . PHE B 1 56  ? 117.425 147.126 123.242 1.00 50.50  ? 56  PHE B CG  1 
ATOM   2449 C CD1 . PHE B 1 56  ? 118.031 147.022 122.002 1.00 50.50  ? 56  PHE B CD1 1 
ATOM   2450 C CD2 . PHE B 1 56  ? 118.011 147.933 124.203 1.00 50.50  ? 56  PHE B CD2 1 
ATOM   2451 C CE1 . PHE B 1 56  ? 119.206 147.693 121.732 1.00 50.50  ? 56  PHE B CE1 1 
ATOM   2452 C CE2 . PHE B 1 56  ? 119.183 148.608 123.938 1.00 50.50  ? 56  PHE B CE2 1 
ATOM   2453 C CZ  . PHE B 1 56  ? 119.782 148.488 122.702 1.00 50.50  ? 56  PHE B CZ  1 
ATOM   2454 N N   . LEU B 1 57  ? 113.033 145.670 123.512 1.00 49.10  ? 57  LEU B N   1 
ATOM   2455 C CA  . LEU B 1 57  ? 111.910 144.860 123.061 1.00 49.10  ? 57  LEU B CA  1 
ATOM   2456 C C   . LEU B 1 57  ? 110.819 145.721 122.443 1.00 49.10  ? 57  LEU B C   1 
ATOM   2457 O O   . LEU B 1 57  ? 110.083 145.248 121.573 1.00 49.10  ? 57  LEU B O   1 
ATOM   2458 C CB  . LEU B 1 57  ? 111.359 144.037 124.218 1.00 49.10  ? 57  LEU B CB  1 
ATOM   2459 C CG  . LEU B 1 57  ? 112.325 143.039 124.849 1.00 49.10  ? 57  LEU B CG  1 
ATOM   2460 C CD1 . LEU B 1 57  ? 111.762 142.543 126.163 1.00 49.10  ? 57  LEU B CD1 1 
ATOM   2461 C CD2 . LEU B 1 57  ? 112.589 141.882 123.905 1.00 49.10  ? 57  LEU B CD2 1 
ATOM   2462 N N   . SER B 1 58  ? 110.703 146.983 122.863 1.00 48.25  ? 58  SER B N   1 
ATOM   2463 C CA  . SER B 1 58  ? 109.754 147.889 122.228 1.00 48.25  ? 58  SER B CA  1 
ATOM   2464 C C   . SER B 1 58  ? 110.161 148.188 120.794 1.00 48.25  ? 58  SER B C   1 
ATOM   2465 O O   . SER B 1 58  ? 109.312 148.223 119.898 1.00 48.25  ? 58  SER B O   1 
ATOM   2466 C CB  . SER B 1 58  ? 109.643 149.180 123.037 1.00 48.25  ? 58  SER B CB  1 
ATOM   2467 O OG  . SER B 1 58  ? 109.111 148.930 124.326 1.00 48.25  ? 58  SER B OG  1 
ATOM   2468 N N   . CYS B 1 59  ? 111.456 148.411 120.560 1.00 49.94  ? 59  CYS B N   1 
ATOM   2469 C CA  . CYS B 1 59  ? 111.935 148.589 119.192 1.00 49.94  ? 59  CYS B CA  1 
ATOM   2470 C C   . CYS B 1 59  ? 111.700 147.329 118.367 1.00 49.94  ? 59  CYS B C   1 
ATOM   2471 O O   . CYS B 1 59  ? 111.298 147.403 117.197 1.00 49.94  ? 59  CYS B O   1 
ATOM   2472 C CB  . CYS B 1 59  ? 113.415 148.963 119.197 1.00 49.94  ? 59  CYS B CB  1 
ATOM   2473 S SG  . CYS B 1 59  ? 113.774 150.547 119.982 1.00 49.94  ? 59  CYS B SG  1 
ATOM   2474 N N   . GLY B 1 60  ? 111.940 146.160 118.964 1.00 47.82  ? 60  GLY B N   1 
ATOM   2475 C CA  . GLY B 1 60  ? 111.656 144.916 118.266 1.00 47.82  ? 60  GLY B CA  1 
ATOM   2476 C C   . GLY B 1 60  ? 110.191 144.768 117.900 1.00 47.82  ? 60  GLY B C   1 
ATOM   2477 O O   . GLY B 1 60  ? 109.859 144.367 116.783 1.00 47.82  ? 60  GLY B O   1 
ATOM   2478 N N   . LEU B 1 61  ? 109.293 145.095 118.833 1.00 46.38  ? 61  LEU B N   1 
ATOM   2479 C CA  . LEU B 1 61  ? 107.864 145.015 118.547 1.00 46.38  ? 61  LEU B CA  1 
ATOM   2480 C C   . LEU B 1 61  ? 107.439 146.041 117.511 1.00 46.38  ? 61  LEU B C   1 
ATOM   2481 O O   . LEU B 1 61  ? 106.547 145.765 116.705 1.00 46.38  ? 61  LEU B O   1 
ATOM   2482 C CB  . LEU B 1 61  ? 107.044 145.197 119.821 1.00 46.38  ? 61  LEU B CB  1 
ATOM   2483 C CG  . LEU B 1 61  ? 106.878 143.971 120.711 1.00 46.38  ? 61  LEU B CG  1 
ATOM   2484 C CD1 . LEU B 1 61  ? 106.184 144.346 121.997 1.00 46.38  ? 61  LEU B CD1 1 
ATOM   2485 C CD2 . LEU B 1 61  ? 106.076 142.921 119.970 1.00 46.38  ? 61  LEU B CD2 1 
ATOM   2486 N N   . LEU B 1 62  ? 108.053 147.224 117.516 1.00 46.95  ? 62  LEU B N   1 
ATOM   2487 C CA  . LEU B 1 62  ? 107.792 148.185 116.452 1.00 46.95  ? 62  LEU B CA  1 
ATOM   2488 C C   . LEU B 1 62  ? 108.194 147.616 115.099 1.00 46.95  ? 62  LEU B C   1 
ATOM   2489 O O   . LEU B 1 62  ? 107.467 147.770 114.112 1.00 46.95  ? 62  LEU B O   1 
ATOM   2490 C CB  . LEU B 1 62  ? 108.531 149.492 116.728 1.00 46.95  ? 62  LEU B CB  1 
ATOM   2491 C CG  . LEU B 1 62  ? 107.855 150.459 117.699 1.00 46.95  ? 62  LEU B CG  1 
ATOM   2492 C CD1 . LEU B 1 62  ? 108.779 151.620 118.031 1.00 46.95  ? 62  LEU B CD1 1 
ATOM   2493 C CD2 . LEU B 1 62  ? 106.547 150.962 117.117 1.00 46.95  ? 62  LEU B CD2 1 
ATOM   2494 N N   . LEU B 1 63  ? 109.344 146.944 115.037 1.00 45.81  ? 63  LEU B N   1 
ATOM   2495 C CA  . LEU B 1 63  ? 109.761 146.309 113.790 1.00 45.81  ? 63  LEU B CA  1 
ATOM   2496 C C   . LEU B 1 63  ? 108.780 145.222 113.361 1.00 45.81  ? 63  LEU B C   1 
ATOM   2497 O O   . LEU B 1 63  ? 108.433 145.112 112.176 1.00 45.81  ? 63  LEU B O   1 
ATOM   2498 C CB  . LEU B 1 63  ? 111.167 145.732 113.952 1.00 45.81  ? 63  LEU B CB  1 
ATOM   2499 C CG  . LEU B 1 63  ? 111.962 145.471 112.674 1.00 45.81  ? 63  LEU B CG  1 
ATOM   2500 C CD1 . LEU B 1 63  ? 112.322 146.780 111.988 1.00 45.81  ? 63  LEU B CD1 1 
ATOM   2501 C CD2 . LEU B 1 63  ? 113.210 144.658 112.976 1.00 45.81  ? 63  LEU B CD2 1 
ATOM   2502 N N   . ILE B 1 64  ? 108.324 144.407 114.313 1.00 44.58  ? 64  ILE B N   1 
ATOM   2503 C CA  . ILE B 1 64  ? 107.399 143.322 113.994 1.00 44.58  ? 64  ILE B CA  1 
ATOM   2504 C C   . ILE B 1 64  ? 106.074 143.874 113.491 1.00 44.58  ? 64  ILE B C   1 
ATOM   2505 O O   . ILE B 1 64  ? 105.506 143.372 112.515 1.00 44.58  ? 64  ILE B O   1 
ATOM   2506 C CB  . ILE B 1 64  ? 107.200 142.414 115.220 1.00 44.58  ? 64  ILE B CB  1 
ATOM   2507 C CG1 . ILE B 1 64  ? 108.537 141.830 115.656 1.00 44.58  ? 64  ILE B CG1 1 
ATOM   2508 C CG2 . ILE B 1 64  ? 106.191 141.319 114.930 1.00 44.58  ? 64  ILE B CG2 1 
ATOM   2509 C CD1 . ILE B 1 64  ? 109.194 140.987 114.612 1.00 44.58  ? 64  ILE B CD1 1 
ATOM   2510 N N   . LEU B 1 65  ? 105.560 144.912 114.151 1.00 43.02  ? 65  LEU B N   1 
ATOM   2511 C CA  . LEU B 1 65  ? 104.327 145.546 113.703 1.00 43.02  ? 65  LEU B CA  1 
ATOM   2512 C C   . LEU B 1 65  ? 104.506 146.216 112.349 1.00 43.02  ? 65  LEU B C   1 
ATOM   2513 O O   . LEU B 1 65  ? 103.571 146.243 111.544 1.00 43.02  ? 65  LEU B O   1 
ATOM   2514 C CB  . LEU B 1 65  ? 103.864 146.557 114.749 1.00 43.02  ? 65  LEU B CB  1 
ATOM   2515 C CG  . LEU B 1 65  ? 103.448 145.949 116.088 1.00 43.02  ? 65  LEU B CG  1 
ATOM   2516 C CD1 . LEU B 1 65  ? 103.140 147.034 117.105 1.00 43.02  ? 65  LEU B CD1 1 
ATOM   2517 C CD2 . LEU B 1 65  ? 102.256 145.021 115.910 1.00 43.02  ? 65  LEU B CD2 1 
ATOM   2518 N N   . PHE B 1 66  ? 105.698 146.752 112.080 1.00 43.44  ? 66  PHE B N   1 
ATOM   2519 C CA  . PHE B 1 66  ? 105.986 147.300 110.762 1.00 43.44  ? 66  PHE B CA  1 
ATOM   2520 C C   . PHE B 1 66  ? 105.903 146.224 109.690 1.00 43.44  ? 66  PHE B C   1 
ATOM   2521 O O   . PHE B 1 66  ? 105.317 146.444 108.625 1.00 43.44  ? 66  PHE B O   1 
ATOM   2522 C CB  . PHE B 1 66  ? 107.369 147.950 110.764 1.00 43.44  ? 66  PHE B CB  1 
ATOM   2523 C CG  . PHE B 1 66  ? 107.874 148.313 109.399 1.00 43.44  ? 66  PHE B CG  1 
ATOM   2524 C CD1 . PHE B 1 66  ? 107.115 149.097 108.551 1.00 43.44  ? 66  PHE B CD1 1 
ATOM   2525 C CD2 . PHE B 1 66  ? 109.108 147.872 108.966 1.00 43.44  ? 66  PHE B CD2 1 
ATOM   2526 C CE1 . PHE B 1 66  ? 107.579 149.432 107.297 1.00 43.44  ? 66  PHE B CE1 1 
ATOM   2527 C CE2 . PHE B 1 66  ? 109.576 148.205 107.713 1.00 43.44  ? 66  PHE B CE2 1 
ATOM   2528 C CZ  . PHE B 1 66  ? 108.809 148.986 106.878 1.00 43.44  ? 66  PHE B CZ  1 
ATOM   2529 N N   . PHE B 1 67  ? 106.481 145.051 109.954 1.00 43.96  ? 67  PHE B N   1 
ATOM   2530 C CA  . PHE B 1 67  ? 106.403 143.972 108.973 1.00 43.96  ? 67  PHE B CA  1 
ATOM   2531 C C   . PHE B 1 67  ? 104.973 143.467 108.819 1.00 43.96  ? 67  PHE B C   1 
ATOM   2532 O O   . PHE B 1 67  ? 104.539 143.137 107.708 1.00 43.96  ? 67  PHE B O   1 
ATOM   2533 C CB  . PHE B 1 67  ? 107.329 142.824 109.364 1.00 43.96  ? 67  PHE B CB  1 
ATOM   2534 C CG  . PHE B 1 67  ? 108.784 143.175 109.311 1.00 43.96  ? 67  PHE B CG  1 
ATOM   2535 C CD1 . PHE B 1 67  ? 109.316 143.820 108.209 1.00 43.96  ? 67  PHE B CD1 1 
ATOM   2536 C CD2 . PHE B 1 67  ? 109.616 142.889 110.376 1.00 43.96  ? 67  PHE B CD2 1 
ATOM   2537 C CE1 . PHE B 1 67  ? 110.651 144.151 108.165 1.00 43.96  ? 67  PHE B CE1 1 
ATOM   2538 C CE2 . PHE B 1 67  ? 110.953 143.212 110.329 1.00 43.96  ? 67  PHE B CE2 1 
ATOM   2539 C CZ  . PHE B 1 67  ? 111.470 143.850 109.224 1.00 43.96  ? 67  PHE B CZ  1 
ATOM   2540 N N   . LEU B 1 68  ? 104.236 143.390 109.929 1.00 45.84  ? 68  LEU B N   1 
ATOM   2541 C CA  . LEU B 1 68  ? 102.815 143.060 109.887 1.00 45.84  ? 68  LEU B CA  1 
ATOM   2542 C C   . LEU B 1 68  ? 102.063 143.998 108.956 1.00 45.84  ? 68  LEU B C   1 
ATOM   2543 O O   . LEU B 1 68  ? 101.321 143.558 108.070 1.00 45.84  ? 68  LEU B O   1 
ATOM   2544 C CB  . LEU B 1 68  ? 102.239 143.121 111.302 1.00 45.84  ? 68  LEU B CB  1 
ATOM   2545 C CG  . LEU B 1 68  ? 100.741 142.901 111.492 1.00 45.84  ? 68  LEU B CG  1 
ATOM   2546 C CD1 . LEU B 1 68  ? 100.383 141.457 111.219 1.00 45.84  ? 68  LEU B CD1 1 
ATOM   2547 C CD2 . LEU B 1 68  ? 100.318 143.304 112.894 1.00 45.84  ? 68  LEU B CD2 1 
ATOM   2548 N N   . ALA B 1 69  ? 102.241 145.305 109.157 1.00 45.74  ? 69  ALA B N   1 
ATOM   2549 C CA  . ALA B 1 69  ? 101.549 146.288 108.335 1.00 45.74  ? 69  ALA B CA  1 
ATOM   2550 C C   . ALA B 1 69  ? 101.988 146.191 106.883 1.00 45.74  ? 69  ALA B C   1 
ATOM   2551 O O   . ALA B 1 69  ? 101.168 146.333 105.972 1.00 45.74  ? 69  ALA B O   1 
ATOM   2552 C CB  . ALA B 1 69  ? 101.793 147.694 108.880 1.00 45.74  ? 69  ALA B CB  1 
ATOM   2553 N N   . PHE B 1 70  ? 103.277 145.954 106.646 1.00 45.26  ? 70  PHE B N   1 
ATOM   2554 C CA  . PHE B 1 70  ? 103.777 145.838 105.281 1.00 45.26  ? 70  PHE B CA  1 
ATOM   2555 C C   . PHE B 1 70  ? 103.117 144.666 104.565 1.00 45.26  ? 70  PHE B C   1 
ATOM   2556 O O   . PHE B 1 70  ? 102.664 144.796 103.423 1.00 45.26  ? 70  PHE B O   1 
ATOM   2557 C CB  . PHE B 1 70  ? 105.302 145.694 105.313 1.00 45.26  ? 70  PHE B CB  1 
ATOM   2558 C CG  . PHE B 1 70  ? 105.909 145.171 104.041 1.00 45.26  ? 70  PHE B CG  1 
ATOM   2559 C CD1 . PHE B 1 70  ? 105.518 145.658 102.805 1.00 45.26  ? 70  PHE B CD1 1 
ATOM   2560 C CD2 . PHE B 1 70  ? 106.894 144.202 104.088 1.00 45.26  ? 70  PHE B CD2 1 
ATOM   2561 C CE1 . PHE B 1 70  ? 106.086 145.175 101.643 1.00 45.26  ? 70  PHE B CE1 1 
ATOM   2562 C CE2 . PHE B 1 70  ? 107.464 143.716 102.931 1.00 45.26  ? 70  PHE B CE2 1 
ATOM   2563 C CZ  . PHE B 1 70  ? 107.061 144.203 101.707 1.00 45.26  ? 70  PHE B CZ  1 
ATOM   2564 N N   . THR B 1 71  ? 103.034 143.514 105.235 1.00 45.31  ? 71  THR B N   1 
ATOM   2565 C CA  . THR B 1 71  ? 102.402 142.348 104.623 1.00 45.31  ? 71  THR B CA  1 
ATOM   2566 C C   . THR B 1 71  ? 100.910 142.570 104.407 1.00 45.31  ? 71  THR B C   1 
ATOM   2567 O O   . THR B 1 71  ? 100.369 142.205 103.358 1.00 45.31  ? 71  THR B O   1 
ATOM   2568 C CB  . THR B 1 71  ? 102.642 141.111 105.485 1.00 45.31  ? 71  THR B CB  1 
ATOM   2569 O OG1 . THR B 1 71  ? 104.048 140.849 105.560 1.00 45.31  ? 71  THR B OG1 1 
ATOM   2570 C CG2 . THR B 1 71  ? 101.941 139.903 104.897 1.00 45.31  ? 71  THR B CG2 1 
ATOM   2571 N N   . ILE B 1 72  ? 100.232 143.179 105.383 1.00 48.37  ? 72  ILE B N   1 
ATOM   2572 C CA  . ILE B 1 72  ? 98.798  143.425 105.252 1.00 48.37  ? 72  ILE B CA  1 
ATOM   2573 C C   . ILE B 1 72  ? 98.523  144.414 104.126 1.00 48.37  ? 72  ILE B C   1 
ATOM   2574 O O   . ILE B 1 72  ? 97.523  144.296 103.407 1.00 48.37  ? 72  ILE B O   1 
ATOM   2575 C CB  . ILE B 1 72  ? 98.219  143.912 106.594 1.00 48.37  ? 72  ILE B CB  1 
ATOM   2576 C CG1 . ILE B 1 72  ? 98.220  142.778 107.619 1.00 48.37  ? 72  ILE B CG1 1 
ATOM   2577 C CG2 . ILE B 1 72  ? 96.811  144.459 106.417 1.00 48.37  ? 72  ILE B CG2 1 
ATOM   2578 C CD1 . ILE B 1 72  ? 98.011  143.248 109.039 1.00 48.37  ? 72  ILE B CD1 1 
ATOM   2579 N N   . HIS B 1 73  ? 99.404  145.393 103.944 1.00 48.92  ? 73  HIS B N   1 
ATOM   2580 C CA  . HIS B 1 73  ? 99.170  146.479 103.006 1.00 48.92  ? 73  HIS B CA  1 
ATOM   2581 C C   . HIS B 1 73  ? 99.622  146.150 101.594 1.00 48.92  ? 73  HIS B C   1 
ATOM   2582 O O   . HIS B 1 73  ? 99.080  146.709 100.634 1.00 48.92  ? 73  HIS B O   1 
ATOM   2583 C CB  . HIS B 1 73  ? 99.889  147.742 103.492 1.00 48.92  ? 73  HIS B CB  1 
ATOM   2584 C CG  . HIS B 1 73  ? 99.443  148.997 102.811 1.00 48.92  ? 73  HIS B CG  1 
ATOM   2585 N ND1 . HIS B 1 73  ? 98.452  149.807 103.320 1.00 48.92  ? 73  HIS B ND1 1 
ATOM   2586 C CD2 . HIS B 1 73  ? 99.859  149.586 101.666 1.00 48.92  ? 73  HIS B CD2 1 
ATOM   2587 C CE1 . HIS B 1 73  ? 98.273  150.839 102.515 1.00 48.92  ? 73  HIS B CE1 1 
ATOM   2588 N NE2 . HIS B 1 73  ? 99.115  150.728 101.503 1.00 48.92  ? 73  HIS B NE2 1 
ATOM   2589 N N   . CYS B 1 74  ? 100.599 145.265 101.441 1.00 48.50  ? 74  CYS B N   1 
ATOM   2590 C CA  . CYS B 1 74  ? 101.153 144.933 100.137 1.00 48.50  ? 74  CYS B CA  1 
ATOM   2591 C C   . CYS B 1 74  ? 101.100 143.433 99.878  1.00 48.50  ? 74  CYS B C   1 
ATOM   2592 O O   . CYS B 1 74  ? 102.058 142.839 99.384  1.00 48.50  ? 74  CYS B O   1 
ATOM   2593 C CB  . CYS B 1 74  ? 102.585 145.448 100.009 1.00 48.50  ? 74  CYS B CB  1 
ATOM   2594 S SG  . CYS B 1 74  ? 102.777 147.216 100.338 1.00 48.50  ? 74  CYS B SG  1 
ATOM   2595 N N   . ARG B 1 75  ? 99.979  142.797 100.205 1.00 46.59  ? 75  ARG B N   1 
ATOM   2596 C CA  . ARG B 1 75  ? 99.812  141.382 99.881  1.00 46.59  ? 75  ARG B CA  1 
ATOM   2597 C C   . ARG B 1 75  ? 99.201  141.204 98.491  1.00 46.59  ? 75  ARG B C   1 
ATOM   2598 O O   . ARG B 1 75  ? 98.316  140.387 98.244  1.00 46.59  ? 75  ARG B O   1 
ATOM   2599 C CB  . ARG B 1 75  ? 98.990  140.691 100.970 1.00 46.59  ? 75  ARG B CB  1 
ATOM   2600 C CG  . ARG B 1 75  ? 97.462  140.859 100.942 1.00 46.59  ? 75  ARG B CG  1 
ATOM   2601 C CD  . ARG B 1 75  ? 97.006  142.298 101.074 1.00 46.59  ? 75  ARG B CD  1 
ATOM   2602 N NE  . ARG B 1 75  ? 95.560  142.390 101.228 1.00 46.59  ? 75  ARG B NE  1 
ATOM   2603 C CZ  . ARG B 1 75  ? 94.699  142.387 100.220 1.00 46.59  ? 75  ARG B CZ  1 
ATOM   2604 N NH1 . ARG B 1 75  ? 95.105  142.309 98.964  1.00 46.59  ? 75  ARG B NH1 1 
ATOM   2605 N NH2 . ARG B 1 75  ? 93.397  142.467 100.480 1.00 46.59  ? 75  ARG B NH2 1 
ATOM   2606 N N   . LYS B 1 76  ? 99.755  141.948 97.538  1.00 49.67  ? 76  LYS B N   1 
ATOM   2607 C CA  . LYS B 1 76  ? 99.366  141.820 96.143  1.00 49.67  ? 76  LYS B CA  1 
ATOM   2608 C C   . LYS B 1 76  ? 100.546 141.926 95.190  1.00 49.67  ? 76  LYS B C   1 
ATOM   2609 O O   . LYS B 1 76  ? 100.340 141.869 93.974  1.00 49.67  ? 76  LYS B O   1 
ATOM   2610 C CB  . LYS B 1 76  ? 98.316  142.882 95.777  1.00 49.67  ? 76  LYS B CB  1 
ATOM   2611 C CG  . LYS B 1 76  ? 96.884  142.464 96.069  1.00 49.67  ? 76  LYS B CG  1 
ATOM   2612 C CD  . LYS B 1 76  ? 95.889  143.466 95.506  1.00 49.67  ? 76  LYS B CD  1 
ATOM   2613 C CE  . LYS B 1 76  ? 94.462  142.956 95.631  1.00 49.67  ? 76  LYS B CE  1 
ATOM   2614 N NZ  . LYS B 1 76  ? 93.478  143.913 95.054  1.00 49.67  ? 76  LYS B NZ  1 
ATOM   2615 N N   . ASN B 1 77  ? 101.764 142.073 95.694  1.00 50.93  ? 77  ASN B N   1 
ATOM   2616 C CA  . ASN B 1 77  ? 102.946 142.151 94.855  1.00 50.93  ? 77  ASN B CA  1 
ATOM   2617 C C   . ASN B 1 77  ? 103.468 140.752 94.559  1.00 50.93  ? 77  ASN B C   1 
ATOM   2618 O O   . ASN B 1 77  ? 103.176 139.790 95.273  1.00 50.93  ? 77  ASN B O   1 
ATOM   2619 C CB  . ASN B 1 77  ? 104.032 142.990 95.528  1.00 50.93  ? 77  ASN B CB  1 
ATOM   2620 C CG  . ASN B 1 77  ? 105.011 143.580 94.535  1.00 50.93  ? 77  ASN B CG  1 
ATOM   2621 O OD1 . ASN B 1 77  ? 105.033 143.198 93.366  1.00 50.93  ? 77  ASN B OD1 1 
ATOM   2622 N ND2 . ASN B 1 77  ? 105.830 144.518 94.997  1.00 50.93  ? 77  ASN B ND2 1 
ATOM   2623 N N   . ARG B 1 78  ? 104.248 140.647 93.482  1.00 50.23  ? 78  ARG B N   1 
ATOM   2624 C CA  . ARG B 1 78  ? 104.775 139.348 93.078  1.00 50.23  ? 78  ARG B CA  1 
ATOM   2625 C C   . ARG B 1 78  ? 105.649 138.749 94.171  1.00 50.23  ? 78  ARG B C   1 
ATOM   2626 O O   . ARG B 1 78  ? 105.503 137.572 94.524  1.00 50.23  ? 78  ARG B O   1 
ATOM   2627 C CB  . ARG B 1 78  ? 105.559 139.487 91.775  1.00 50.23  ? 78  ARG B CB  1 
ATOM   2628 C CG  . ARG B 1 78  ? 106.266 138.217 91.341  1.00 50.23  ? 78  ARG B CG  1 
ATOM   2629 C CD  . ARG B 1 78  ? 107.030 138.427 90.044  1.00 50.23  ? 78  ARG B CD  1 
ATOM   2630 N NE  . ARG B 1 78  ? 106.136 138.529 88.896  1.00 50.23  ? 78  ARG B NE  1 
ATOM   2631 C CZ  . ARG B 1 78  ? 106.526 138.843 87.669  1.00 50.23  ? 78  ARG B CZ  1 
ATOM   2632 N NH1 . ARG B 1 78  ? 107.794 139.095 87.389  1.00 50.23  ? 78  ARG B NH1 1 
ATOM   2633 N NH2 . ARG B 1 78  ? 105.620 138.905 86.697  1.00 50.23  ? 78  ARG B NH2 1 
ATOM   2634 N N   . ILE B 1 79  ? 106.554 139.551 94.732  1.00 47.59  ? 79  ILE B N   1 
ATOM   2635 C CA  . ILE B 1 79  ? 107.469 139.043 95.749  1.00 47.59  ? 79  ILE B CA  1 
ATOM   2636 C C   . ILE B 1 79  ? 106.706 138.650 97.007  1.00 47.59  ? 79  ILE B C   1 
ATOM   2637 O O   . ILE B 1 79  ? 106.928 137.574 97.576  1.00 47.59  ? 79  ILE B O   1 
ATOM   2638 C CB  . ILE B 1 79  ? 108.561 140.082 96.054  1.00 47.59  ? 79  ILE B CB  1 
ATOM   2639 C CG1 . ILE B 1 79  ? 109.143 140.641 94.756  1.00 47.59  ? 79  ILE B CG1 1 
ATOM   2640 C CG2 . ILE B 1 79  ? 109.654 139.465 96.908  1.00 47.59  ? 79  ILE B CG2 1 
ATOM   2641 C CD1 . ILE B 1 79  ? 109.867 139.610 93.917  1.00 47.59  ? 79  ILE B CD1 1 
ATOM   2642 N N   . VAL B 1 80  ? 105.796 139.513 97.460  1.00 45.48  ? 80  VAL B N   1 
ATOM   2643 C CA  . VAL B 1 80  ? 105.082 139.237 98.702  1.00 45.48  ? 80  VAL B CA  1 
ATOM   2644 C C   . VAL B 1 80  ? 104.179 138.022 98.543  1.00 45.48  ? 80  VAL B C   1 
ATOM   2645 O O   . VAL B 1 80  ? 104.121 137.159 99.427  1.00 45.48  ? 80  VAL B O   1 
ATOM   2646 C CB  . VAL B 1 80  ? 104.293 140.475 99.156  1.00 45.48  ? 80  VAL B CB  1 
ATOM   2647 C CG1 . VAL B 1 80  ? 103.748 140.262 100.556 1.00 45.48  ? 80  VAL B CG1 1 
ATOM   2648 C CG2 . VAL B 1 80  ? 105.176 141.711 99.106  1.00 45.48  ? 80  VAL B CG2 1 
ATOM   2649 N N   . LYS B 1 81  ? 103.465 137.930 97.419  1.00 45.92  ? 81  LYS B N   1 
ATOM   2650 C CA  . LYS B 1 81  ? 102.618 136.766 97.175  1.00 45.92  ? 81  LYS B CA  1 
ATOM   2651 C C   . LYS B 1 81  ? 103.443 135.490 97.083  1.00 45.92  ? 81  LYS B C   1 
ATOM   2652 O O   . LYS B 1 81  ? 103.051 134.448 97.621  1.00 45.92  ? 81  LYS B O   1 
ATOM   2653 C CB  . LYS B 1 81  ? 101.803 136.963 95.898  1.00 45.92  ? 81  LYS B CB  1 
ATOM   2654 C CG  . LYS B 1 81  ? 100.622 137.906 96.046  1.00 45.92  ? 81  LYS B CG  1 
ATOM   2655 C CD  . LYS B 1 81  ? 99.920  138.113 94.713  1.00 45.92  ? 81  LYS B CD  1 
ATOM   2656 C CE  . LYS B 1 81  ? 99.136  136.876 94.303  1.00 45.92  ? 81  LYS B CE  1 
ATOM   2657 N NZ  . LYS B 1 81  ? 97.966  136.638 95.191  1.00 45.92  ? 81  LYS B NZ  1 
ATOM   2658 N N   . MET B 1 82  ? 104.622 135.567 96.508  1.00 45.64  ? 82  MET B N   1 
ATOM   2659 C CA  . MET B 1 82  ? 105.493 134.425 96.400  1.00 45.64  ? 82  MET B CA  1 
ATOM   2660 C C   . MET B 1 82  ? 106.082 134.044 97.697  1.00 45.64  ? 82  MET B C   1 
ATOM   2661 O O   . MET B 1 82  ? 106.518 132.920 97.879  1.00 45.64  ? 82  MET B O   1 
ATOM   2662 C CB  . MET B 1 82  ? 106.641 134.756 95.485  1.00 45.64  ? 82  MET B CB  1 
ATOM   2663 C CG  . MET B 1 82  ? 106.347 134.526 94.020  1.00 45.64  ? 82  MET B CG  1 
ATOM   2664 S SD  . MET B 1 82  ? 106.072 132.779 93.704  1.00 45.64  ? 82  MET B SD  1 
ATOM   2665 C CE  . MET B 1 82  ? 107.598 132.085 94.334  1.00 45.64  ? 82  MET B CE  1 
ATOM   2666 N N   . SER B 1 83  ? 106.126 134.965 98.598  1.00 42.27  ? 83  SER B N   1 
ATOM   2667 C CA  . SER B 1 83  ? 106.696 134.723 99.915  1.00 42.27  ? 83  SER B CA  1 
ATOM   2668 C C   . SER B 1 83  ? 105.667 134.255 100.939 1.00 42.27  ? 83  SER B C   1 
ATOM   2669 O O   . SER B 1 83  ? 105.956 134.287 102.140 1.00 42.27  ? 83  SER B O   1 
ATOM   2670 C CB  . SER B 1 83  ? 107.389 135.986 100.427 1.00 42.27  ? 83  SER B CB  1 
ATOM   2671 O OG  . SER B 1 83  ? 107.770 135.837 101.783 1.00 42.27  ? 83  SER B OG  1 
ATOM   2672 N N   . SER B 1 84  ? 104.481 133.820 100.495 1.00 43.07  ? 84  SER B N   1 
ATOM   2673 C CA  . SER B 1 84  ? 103.432 133.285 101.360 1.00 43.07  ? 84  SER B CA  1 
ATOM   2674 C C   . SER B 1 84  ? 103.064 134.249 102.485 1.00 43.07  ? 84  SER B C   1 
ATOM   2675 O O   . SER B 1 84  ? 103.465 134.042 103.637 1.00 43.07  ? 84  SER B O   1 
ATOM   2676 C CB  . SER B 1 84  ? 103.858 131.936 101.939 1.00 43.07  ? 84  SER B CB  1 
ATOM   2677 O OG  . SER B 1 84  ? 103.990 130.967 100.914 1.00 43.07  ? 84  SER B OG  1 
ATOM   2678 N N   . PRO B 1 85  ? 102.319 135.317 102.185 1.00 40.40  ? 85  PRO B N   1 
ATOM   2679 C CA  . PRO B 1 85  ? 102.019 136.324 103.217 1.00 40.40  ? 85  PRO B CA  1 
ATOM   2680 C C   . PRO B 1 85  ? 101.287 135.776 104.430 1.00 40.40  ? 85  PRO B C   1 
ATOM   2681 O O   . PRO B 1 85  ? 101.469 136.299 105.536 1.00 40.40  ? 85  PRO B O   1 
ATOM   2682 C CB  . PRO B 1 85  ? 101.156 137.346 102.465 1.00 40.40  ? 85  PRO B CB  1 
ATOM   2683 C CG  . PRO B 1 85  ? 101.383 137.073 101.020 1.00 40.40  ? 85  PRO B CG  1 
ATOM   2684 C CD  . PRO B 1 85  ? 101.656 135.619 100.909 1.00 40.40  ? 85  PRO B CD  1 
ATOM   2685 N N   . ASN B 1 86  ? 100.458 134.745 104.259 1.00 42.17  ? 86  ASN B N   1 
ATOM   2686 C CA  . ASN B 1 86  ? 99.712  134.198 105.388 1.00 42.17  ? 86  ASN B CA  1 
ATOM   2687 C C   . ASN B 1 86  ? 100.640 133.511 106.383 1.00 42.17  ? 86  ASN B C   1 
ATOM   2688 O O   . ASN B 1 86  ? 100.508 133.691 107.601 1.00 42.17  ? 86  ASN B O   1 
ATOM   2689 C CB  . ASN B 1 86  ? 98.649  133.228 104.881 1.00 42.17  ? 86  ASN B CB  1 
ATOM   2690 C CG  . ASN B 1 86  ? 97.689  133.877 103.907 1.00 42.17  ? 86  ASN B CG  1 
ATOM   2691 O OD1 . ASN B 1 86  ? 97.659  133.533 102.725 1.00 42.17  ? 86  ASN B OD1 1 
ATOM   2692 N ND2 . ASN B 1 86  ? 96.897  134.822 104.398 1.00 42.17  ? 86  ASN B ND2 1 
ATOM   2693 N N   . LEU B 1 87  ? 101.586 132.714 105.887 1.00 41.31  ? 87  LEU B N   1 
ATOM   2694 C CA  . LEU B 1 87  ? 102.532 132.075 106.790 1.00 41.31  ? 87  LEU B CA  1 
ATOM   2695 C C   . LEU B 1 87  ? 103.391 133.117 107.487 1.00 41.31  ? 87  LEU B C   1 
ATOM   2696 O O   . LEU B 1 87  ? 103.750 132.954 108.659 1.00 41.31  ? 87  LEU B O   1 
ATOM   2697 C CB  . LEU B 1 87  ? 103.413 131.084 106.031 1.00 41.31  ? 87  LEU B CB  1 
ATOM   2698 C CG  . LEU B 1 87  ? 102.829 129.701 105.726 1.00 41.31  ? 87  LEU B CG  1 
ATOM   2699 C CD1 . LEU B 1 87  ? 102.457 128.936 106.984 1.00 41.31  ? 87  LEU B CD1 1 
ATOM   2700 C CD2 . LEU B 1 87  ? 101.654 129.810 104.799 1.00 41.31  ? 87  LEU B CD2 1 
ATOM   2701 N N   . ASN B 1 88  ? 103.698 134.211 106.791 1.00 40.48  ? 88  ASN B N   1 
ATOM   2702 C CA  . ASN B 1 88  ? 104.489 135.276 107.391 1.00 40.48  ? 88  ASN B CA  1 
ATOM   2703 C C   . ASN B 1 88  ? 103.707 136.005 108.477 1.00 40.48  ? 88  ASN B C   1 
ATOM   2704 O O   . ASN B 1 88  ? 104.281 136.392 109.500 1.00 40.48  ? 88  ASN B O   1 
ATOM   2705 C CB  . ASN B 1 88  ? 104.955 136.246 106.309 1.00 40.48  ? 88  ASN B CB  1 
ATOM   2706 C CG  . ASN B 1 88  ? 105.926 135.608 105.337 1.00 40.48  ? 88  ASN B CG  1 
ATOM   2707 O OD1 . ASN B 1 88  ? 106.572 134.612 105.654 1.00 40.48  ? 88  ASN B OD1 1 
ATOM   2708 N ND2 . ASN B 1 88  ? 106.029 136.176 104.142 1.00 40.48  ? 88  ASN B ND2 1 
ATOM   2709 N N   . ILE B 1 89  ? 102.398 136.195 108.290 1.00 40.03  ? 89  ILE B N   1 
ATOM   2710 C CA  . ILE B 1 89  ? 101.632 136.848 109.349 1.00 40.03  ? 89  ILE B CA  1 
ATOM   2711 C C   . ILE B 1 89  ? 101.479 135.913 110.542 1.00 40.03  ? 89  ILE B C   1 
ATOM   2712 O O   . ILE B 1 89  ? 101.471 136.363 111.697 1.00 40.03  ? 89  ILE B O   1 
ATOM   2713 C CB  . ILE B 1 89  ? 100.273 137.365 108.832 1.00 40.03  ? 89  ILE B CB  1 
ATOM   2714 C CG1 . ILE B 1 89  ? 99.611  138.255 109.881 1.00 40.03  ? 89  ILE B CG1 1 
ATOM   2715 C CG2 . ILE B 1 89  ? 99.326  136.243 108.499 1.00 40.03  ? 89  ILE B CG2 1 
ATOM   2716 C CD1 . ILE B 1 89  ? 98.354  138.937 109.394 1.00 40.03  ? 89  ILE B CD1 1 
ATOM   2717 N N   . VAL B 1 90  ? 101.386 134.604 110.299 1.00 38.86  ? 90  VAL B N   1 
ATOM   2718 C CA  . VAL B 1 90  ? 101.406 133.651 111.407 1.00 38.86  ? 90  VAL B CA  1 
ATOM   2719 C C   . VAL B 1 90  ? 102.725 133.742 112.168 1.00 38.86  ? 90  VAL B C   1 
ATOM   2720 O O   . VAL B 1 90  ? 102.752 133.744 113.409 1.00 38.86  ? 90  VAL B O   1 
ATOM   2721 C CB  . VAL B 1 90  ? 101.147 132.227 110.887 1.00 38.86  ? 90  VAL B CB  1 
ATOM   2722 C CG1 . VAL B 1 90  ? 101.300 131.231 112.002 1.00 38.86  ? 90  VAL B CG1 1 
ATOM   2723 C CG2 . VAL B 1 90  ? 99.758  132.136 110.282 1.00 38.86  ? 90  VAL B CG2 1 
ATOM   2724 N N   . THR B 1 91  ? 103.838 133.831 111.439 1.00 38.98  ? 91  THR B N   1 
ATOM   2725 C CA  . THR B 1 91  ? 105.141 133.970 112.083 1.00 38.98  ? 91  THR B CA  1 
ATOM   2726 C C   . THR B 1 91  ? 105.224 135.264 112.881 1.00 38.98  ? 91  THR B C   1 
ATOM   2727 O O   . THR B 1 91  ? 105.821 135.303 113.962 1.00 38.98  ? 91  THR B O   1 
ATOM   2728 C CB  . THR B 1 91  ? 106.252 133.920 111.035 1.00 38.98  ? 91  THR B CB  1 
ATOM   2729 O OG1 . THR B 1 91  ? 106.107 132.740 110.238 1.00 38.98  ? 91  THR B OG1 1 
ATOM   2730 C CG2 . THR B 1 91  ? 107.613 133.905 111.699 1.00 38.98  ? 91  THR B CG2 1 
ATOM   2731 N N   . LEU B 1 92  ? 104.638 136.337 112.355 1.00 41.70  ? 92  LEU B N   1 
ATOM   2732 C CA  . LEU B 1 92  ? 104.634 137.614 113.062 1.00 41.70  ? 92  LEU B CA  1 
ATOM   2733 C C   . LEU B 1 92  ? 103.831 137.534 114.354 1.00 41.70  ? 92  LEU B C   1 
ATOM   2734 O O   . LEU B 1 92  ? 104.222 138.115 115.373 1.00 41.70  ? 92  LEU B O   1 
ATOM   2735 C CB  . LEU B 1 92  ? 104.084 138.696 112.141 1.00 41.70  ? 92  LEU B CB  1 
ATOM   2736 C CG  . LEU B 1 92  ? 105.101 139.121 111.087 1.00 41.70  ? 92  LEU B CG  1 
ATOM   2737 C CD1 . LEU B 1 92  ? 104.460 140.007 110.047 1.00 41.70  ? 92  LEU B CD1 1 
ATOM   2738 C CD2 . LEU B 1 92  ? 106.277 139.822 111.738 1.00 41.70  ? 92  LEU B CD2 1 
ATOM   2739 N N   . LEU B 1 93  ? 102.700 136.824 114.331 1.00 40.19  ? 93  LEU B N   1 
ATOM   2740 C CA  . LEU B 1 93  ? 101.944 136.606 115.563 1.00 40.19  ? 93  LEU B CA  1 
ATOM   2741 C C   . LEU B 1 93  ? 102.762 135.808 116.573 1.00 40.19  ? 93  LEU B C   1 
ATOM   2742 O O   . LEU B 1 93  ? 102.751 136.106 117.777 1.00 40.19  ? 93  LEU B O   1 
ATOM   2743 C CB  . LEU B 1 93  ? 100.627 135.898 115.252 1.00 40.19  ? 93  LEU B CB  1 
ATOM   2744 C CG  . LEU B 1 93  ? 99.682  136.653 114.317 1.00 40.19  ? 93  LEU B CG  1 
ATOM   2745 C CD1 . LEU B 1 93  ? 98.351  135.928 114.197 1.00 40.19  ? 93  LEU B CD1 1 
ATOM   2746 C CD2 . LEU B 1 93  ? 99.477  138.077 114.798 1.00 40.19  ? 93  LEU B CD2 1 
ATOM   2747 N N   . GLY B 1 94  ? 103.485 134.794 116.099 1.00 39.63  ? 94  GLY B N   1 
ATOM   2748 C CA  . GLY B 1 94  ? 104.369 134.061 116.991 1.00 39.63  ? 94  GLY B CA  1 
ATOM   2749 C C   . GLY B 1 94  ? 105.440 134.945 117.599 1.00 39.63  ? 94  GLY B C   1 
ATOM   2750 O O   . GLY B 1 94  ? 105.765 134.826 118.784 1.00 39.63  ? 94  GLY B O   1 
ATOM   2751 N N   . SER B 1 95  ? 105.998 135.851 116.797 1.00 42.31  ? 95  SER B N   1 
ATOM   2752 C CA  . SER B 1 95  ? 107.003 136.781 117.303 1.00 42.31  ? 95  SER B CA  1 
ATOM   2753 C C   . SER B 1 95  ? 106.412 137.725 118.343 1.00 42.31  ? 95  SER B C   1 
ATOM   2754 O O   . SER B 1 95  ? 107.075 138.069 119.331 1.00 42.31  ? 95  SER B O   1 
ATOM   2755 C CB  . SER B 1 95  ? 107.612 137.571 116.148 1.00 42.31  ? 95  SER B CB  1 
ATOM   2756 O OG  . SER B 1 95  ? 108.489 136.757 115.389 1.00 42.31  ? 95  SER B OG  1 
ATOM   2757 N N   . CYS B 1 96  ? 105.174 138.173 118.127 1.00 43.15  ? 96  CYS B N   1 
ATOM   2758 C CA  . CYS B 1 96  ? 104.516 139.018 119.119 1.00 43.15  ? 96  CYS B CA  1 
ATOM   2759 C C   . CYS B 1 96  ? 104.332 138.276 120.435 1.00 43.15  ? 96  CYS B C   1 
ATOM   2760 O O   . CYS B 1 96  ? 104.549 138.842 121.515 1.00 43.15  ? 96  CYS B O   1 
ATOM   2761 C CB  . CYS B 1 96  ? 103.171 139.508 118.586 1.00 43.15  ? 96  CYS B CB  1 
ATOM   2762 S SG  . CYS B 1 96  ? 103.286 140.612 117.159 1.00 43.15  ? 96  CYS B SG  1 
ATOM   2763 N N   . LEU B 1 97  ? 103.946 136.999 120.365 1.00 42.37  ? 97  LEU B N   1 
ATOM   2764 C CA  . LEU B 1 97  ? 103.864 136.192 121.582 1.00 42.37  ? 97  LEU B CA  1 
ATOM   2765 C C   . LEU B 1 97  ? 105.226 136.068 122.255 1.00 42.37  ? 97  LEU B C   1 
ATOM   2766 O O   . LEU B 1 97  ? 105.328 136.126 123.489 1.00 42.37  ? 97  LEU B O   1 
ATOM   2767 C CB  . LEU B 1 97  ? 103.298 134.810 121.269 1.00 42.37  ? 97  LEU B CB  1 
ATOM   2768 C CG  . LEU B 1 97  ? 101.849 134.765 120.794 1.00 42.37  ? 97  LEU B CG  1 
ATOM   2769 C CD1 . LEU B 1 97  ? 101.469 133.353 120.390 1.00 42.37  ? 97  LEU B CD1 1 
ATOM   2770 C CD2 . LEU B 1 97  ? 100.912 135.285 121.872 1.00 42.37  ? 97  LEU B CD2 1 
ATOM   2771 N N   . THR B 1 98  ? 106.283 135.881 121.461 1.00 42.98  ? 98  THR B N   1 
ATOM   2772 C CA  . THR B 1 98  ? 107.616 135.726 122.036 1.00 42.98  ? 98  THR B CA  1 
ATOM   2773 C C   . THR B 1 98  ? 108.064 136.990 122.763 1.00 42.98  ? 98  THR B C   1 
ATOM   2774 O O   . THR B 1 98  ? 108.608 136.916 123.872 1.00 42.98  ? 98  THR B O   1 
ATOM   2775 C CB  . THR B 1 98  ? 108.611 135.350 120.942 1.00 42.98  ? 98  THR B CB  1 
ATOM   2776 O OG1 . THR B 1 98  ? 108.063 134.294 120.146 1.00 42.98  ? 98  THR B OG1 1 
ATOM   2777 C CG2 . THR B 1 98  ? 109.907 134.866 121.555 1.00 42.98  ? 98  THR B CG2 1 
ATOM   2778 N N   . TYR B 1 99  ? 107.832 138.164 122.169 1.00 43.24  ? 99  TYR B N   1 
ATOM   2779 C CA  . TYR B 1 99  ? 108.167 139.401 122.876 1.00 43.24  ? 99  TYR B CA  1 
ATOM   2780 C C   . TYR B 1 99  ? 107.263 139.651 124.078 1.00 43.24  ? 99  TYR B C   1 
ATOM   2781 O O   . TYR B 1 99  ? 107.700 140.271 125.054 1.00 43.24  ? 99  TYR B O   1 
ATOM   2782 C CB  . TYR B 1 99  ? 108.148 140.605 121.940 1.00 43.24  ? 99  TYR B CB  1 
ATOM   2783 C CG  . TYR B 1 99  ? 109.172 140.549 120.839 1.00 43.24  ? 99  TYR B CG  1 
ATOM   2784 C CD1 . TYR B 1 99  ? 110.522 140.473 121.140 1.00 43.24  ? 99  TYR B CD1 1 
ATOM   2785 C CD2 . TYR B 1 99  ? 108.804 140.623 119.509 1.00 43.24  ? 99  TYR B CD2 1 
ATOM   2786 C CE1 . TYR B 1 99  ? 111.471 140.442 120.149 1.00 43.24  ? 99  TYR B CE1 1 
ATOM   2787 C CE2 . TYR B 1 99  ? 109.747 140.593 118.513 1.00 43.24  ? 99  TYR B CE2 1 
ATOM   2788 C CZ  . TYR B 1 99  ? 111.079 140.505 118.837 1.00 43.24  ? 99  TYR B CZ  1 
ATOM   2789 O OH  . TYR B 1 99  ? 112.024 140.473 117.839 1.00 43.24  ? 99  TYR B OH  1 
ATOM   2790 N N   . SER B 1 100 ? 106.008 139.199 124.035 1.00 43.91  ? 100 SER B N   1 
ATOM   2791 C CA  . SER B 1 100 ? 105.176 139.288 125.231 1.00 43.91  ? 100 SER B CA  1 
ATOM   2792 C C   . SER B 1 100 ? 105.773 138.465 126.366 1.00 43.91  ? 100 SER B C   1 
ATOM   2793 O O   . SER B 1 100 ? 105.851 138.926 127.512 1.00 43.91  ? 100 SER B O   1 
ATOM   2794 C CB  . SER B 1 100 ? 103.755 138.827 124.915 1.00 43.91  ? 100 SER B CB  1 
ATOM   2795 O OG  . SER B 1 100 ? 103.147 139.681 123.961 1.00 43.91  ? 100 SER B OG  1 
ATOM   2796 N N   . SER B 1 101 ? 106.237 137.255 126.053 1.00 44.34  ? 101 SER B N   1 
ATOM   2797 C CA  . SER B 1 101 ? 106.931 136.449 127.052 1.00 44.34  ? 101 SER B CA  1 
ATOM   2798 C C   . SER B 1 101 ? 108.193 137.147 127.545 1.00 44.34  ? 101 SER B C   1 
ATOM   2799 O O   . SER B 1 101 ? 108.501 137.121 128.746 1.00 44.34  ? 101 SER B O   1 
ATOM   2800 C CB  . SER B 1 101 ? 107.267 135.079 126.471 1.00 44.34  ? 101 SER B CB  1 
ATOM   2801 O OG  . SER B 1 101 ? 108.023 135.206 125.281 1.00 44.34  ? 101 SER B OG  1 
ATOM   2802 N N   . ALA B 1 102 ? 108.915 137.808 126.637 1.00 46.41  ? 102 ALA B N   1 
ATOM   2803 C CA  . ALA B 1 102 ? 110.110 138.548 127.031 1.00 46.41  ? 102 ALA B CA  1 
ATOM   2804 C C   . ALA B 1 102 ? 109.768 139.650 128.023 1.00 46.41  ? 102 ALA B C   1 
ATOM   2805 O O   . ALA B 1 102 ? 110.489 139.855 129.006 1.00 46.41  ? 102 ALA B O   1 
ATOM   2806 C CB  . ALA B 1 102 ? 110.800 139.123 125.797 1.00 46.41  ? 102 ALA B CB  1 
ATOM   2807 N N   . TYR B 1 103 ? 108.674 140.373 127.779 1.00 47.85  ? 103 TYR B N   1 
ATOM   2808 C CA  . TYR B 1 103 ? 108.190 141.347 128.754 1.00 47.85  ? 103 TYR B CA  1 
ATOM   2809 C C   . TYR B 1 103 ? 107.906 140.681 130.095 1.00 47.85  ? 103 TYR B C   1 
ATOM   2810 O O   . TYR B 1 103 ? 108.298 141.194 131.149 1.00 47.85  ? 103 TYR B O   1 
ATOM   2811 C CB  . TYR B 1 103 ? 106.937 142.053 128.235 1.00 47.85  ? 103 TYR B CB  1 
ATOM   2812 C CG  . TYR B 1 103 ? 107.192 143.132 127.211 1.00 47.85  ? 103 TYR B CG  1 
ATOM   2813 C CD1 . TYR B 1 103 ? 108.447 143.698 127.069 1.00 47.85  ? 103 TYR B CD1 1 
ATOM   2814 C CD2 . TYR B 1 103 ? 106.174 143.583 126.384 1.00 47.85  ? 103 TYR B CD2 1 
ATOM   2815 C CE1 . TYR B 1 103 ? 108.679 144.688 126.142 1.00 47.85  ? 103 TYR B CE1 1 
ATOM   2816 C CE2 . TYR B 1 103 ? 106.400 144.571 125.449 1.00 47.85  ? 103 TYR B CE2 1 
ATOM   2817 C CZ  . TYR B 1 103 ? 107.656 145.116 125.329 1.00 47.85  ? 103 TYR B CZ  1 
ATOM   2818 O OH  . TYR B 1 103 ? 107.886 146.101 124.399 1.00 47.85  ? 103 TYR B OH  1 
ATOM   2819 N N   . LEU B 1 104 ? 107.215 139.538 130.077 1.00 47.93  ? 104 LEU B N   1 
ATOM   2820 C CA  . LEU B 1 104 ? 106.893 138.890 131.347 1.00 47.93  ? 104 LEU B CA  1 
ATOM   2821 C C   . LEU B 1 104 ? 108.127 138.402 132.103 1.00 47.93  ? 104 LEU B C   1 
ATOM   2822 O O   . LEU B 1 104 ? 108.043 138.212 133.320 1.00 47.93  ? 104 LEU B O   1 
ATOM   2823 C CB  . LEU B 1 104 ? 105.914 137.731 131.149 1.00 47.93  ? 104 LEU B CB  1 
ATOM   2824 C CG  . LEU B 1 104 ? 104.427 138.105 131.160 1.00 47.93  ? 104 LEU B CG  1 
ATOM   2825 C CD1 . LEU B 1 104 ? 103.971 138.804 129.897 1.00 47.93  ? 104 LEU B CD1 1 
ATOM   2826 C CD2 . LEU B 1 104 ? 103.562 136.894 131.463 1.00 47.93  ? 104 LEU B CD2 1 
ATOM   2827 N N   . PHE B 1 105 ? 109.259 138.184 131.428 1.00 46.99  ? 105 PHE B N   1 
ATOM   2828 C CA  . PHE B 1 105 ? 110.487 137.909 132.184 1.00 46.99  ? 105 PHE B CA  1 
ATOM   2829 C C   . PHE B 1 105 ? 110.898 139.062 133.087 1.00 46.99  ? 105 PHE B C   1 
ATOM   2830 O O   . PHE B 1 105 ? 111.607 138.834 134.072 1.00 46.99  ? 105 PHE B O   1 
ATOM   2831 C CB  . PHE B 1 105 ? 111.672 137.540 131.286 1.00 46.99  ? 105 PHE B CB  1 
ATOM   2832 C CG  . PHE B 1 105 ? 111.533 136.220 130.603 1.00 46.99  ? 105 PHE B CG  1 
ATOM   2833 C CD1 . PHE B 1 105 ? 111.836 135.060 131.288 1.00 46.99  ? 105 PHE B CD1 1 
ATOM   2834 C CD2 . PHE B 1 105 ? 111.086 136.120 129.311 1.00 46.99  ? 105 PHE B CD2 1 
ATOM   2835 C CE1 . PHE B 1 105 ? 111.717 133.836 130.690 1.00 46.99  ? 105 PHE B CE1 1 
ATOM   2836 C CE2 . PHE B 1 105 ? 110.944 134.890 128.718 1.00 46.99  ? 105 PHE B CE2 1 
ATOM   2837 C CZ  . PHE B 1 105 ? 111.270 133.752 129.408 1.00 46.99  ? 105 PHE B CZ  1 
ATOM   2838 N N   . GLY B 1 106 ? 110.477 140.284 132.786 1.00 54.07  ? 106 GLY B N   1 
ATOM   2839 C CA  . GLY B 1 106 ? 110.857 141.429 133.579 1.00 54.07  ? 106 GLY B CA  1 
ATOM   2840 C C   . GLY B 1 106 ? 109.822 141.898 134.569 1.00 54.07  ? 106 GLY B C   1 
ATOM   2841 O O   . GLY B 1 106 ? 110.085 142.843 135.318 1.00 54.07  ? 106 GLY B O   1 
ATOM   2842 N N   . ILE B 1 107 ? 108.651 141.268 134.599 1.00 58.19  ? 107 ILE B N   1 
ATOM   2843 C CA  . ILE B 1 107 ? 107.620 141.595 135.575 1.00 58.19  ? 107 ILE B CA  1 
ATOM   2844 C C   . ILE B 1 107 ? 107.789 140.672 136.775 1.00 58.19  ? 107 ILE B C   1 
ATOM   2845 O O   . ILE B 1 107 ? 106.945 140.637 137.677 1.00 58.19  ? 107 ILE B O   1 
ATOM   2846 C CB  . ILE B 1 107 ? 106.214 141.485 134.954 1.00 58.19  ? 107 ILE B CB  1 
ATOM   2847 C CG1 . ILE B 1 107 ? 105.200 142.314 135.748 1.00 58.19  ? 107 ILE B CG1 1 
ATOM   2848 C CG2 . ILE B 1 107 ? 105.784 140.036 134.839 1.00 58.19  ? 107 ILE B CG2 1 
ATOM   2849 C CD1 . ILE B 1 107 ? 103.890 142.533 135.026 1.00 58.19  ? 107 ILE B CD1 1 
ATOM   2850 N N   . GLN B 1 108 ? 108.893 139.931 136.802 1.00 62.56  ? 108 GLN B N   1 
ATOM   2851 C CA  . GLN B 1 108 ? 109.151 139.020 137.905 1.00 62.56  ? 108 GLN B CA  1 
ATOM   2852 C C   . GLN B 1 108 ? 109.460 139.799 139.180 1.00 62.56  ? 108 GLN B C   1 
ATOM   2853 O O   . GLN B 1 108 ? 109.793 140.987 139.152 1.00 62.56  ? 108 GLN B O   1 
ATOM   2854 C CB  . GLN B 1 108 ? 110.308 138.077 137.571 1.00 62.56  ? 108 GLN B CB  1 
ATOM   2855 C CG  . GLN B 1 108 ? 111.625 138.777 137.285 1.00 62.56  ? 108 GLN B CG  1 
ATOM   2856 C CD  . GLN B 1 108 ? 112.580 138.722 138.463 1.00 62.56  ? 108 GLN B CD  1 
ATOM   2857 O OE1 . GLN B 1 108 ? 112.668 137.709 139.158 1.00 62.56  ? 108 GLN B OE1 1 
ATOM   2858 N NE2 . GLN B 1 108 ? 113.299 139.813 138.694 1.00 62.56  ? 108 GLN B NE2 1 
ATOM   2859 N N   . ASP B 1 109 ? 109.336 139.105 140.313 1.00 67.17  ? 109 ASP B N   1 
ATOM   2860 C CA  . ASP B 1 109 ? 109.528 139.692 141.640 1.00 67.17  ? 109 ASP B CA  1 
ATOM   2861 C C   . ASP B 1 109 ? 108.594 140.877 141.870 1.00 67.17  ? 109 ASP B C   1 
ATOM   2862 O O   . ASP B 1 109 ? 108.946 141.836 142.563 1.00 67.17  ? 109 ASP B O   1 
ATOM   2863 C CB  . ASP B 1 109 ? 110.986 140.105 141.865 1.00 67.17  ? 109 ASP B CB  1 
ATOM   2864 C CG  . ASP B 1 109 ? 111.908 138.914 142.036 1.00 67.17  ? 109 ASP B CG  1 
ATOM   2865 O OD1 . ASP B 1 109 ? 111.422 137.766 141.952 1.00 67.17  ? 109 ASP B OD1 1 
ATOM   2866 O OD2 . ASP B 1 109 ? 113.119 139.127 142.255 1.00 67.17  ? 109 ASP B OD2 1 
ATOM   2867 N N   . VAL B 1 110 ? 107.395 140.816 141.290 1.00 69.69  ? 110 VAL B N   1 
ATOM   2868 C CA  . VAL B 1 110 ? 106.364 141.829 141.475 1.00 69.69  ? 110 VAL B CA  1 
ATOM   2869 C C   . VAL B 1 110 ? 105.093 141.222 142.057 1.00 69.69  ? 110 VAL B C   1 
ATOM   2870 O O   . VAL B 1 110 ? 104.510 141.760 143.004 1.00 69.69  ? 110 VAL B O   1 
ATOM   2871 C CB  . VAL B 1 110 ? 106.059 142.570 140.154 1.00 69.69  ? 110 VAL B CB  1 
ATOM   2872 C CG1 . VAL B 1 110 ? 104.894 143.530 140.335 1.00 69.69  ? 110 VAL B CG1 1 
ATOM   2873 C CG2 . VAL B 1 110 ? 107.294 143.308 139.661 1.00 69.69  ? 110 VAL B CG2 1 
ATOM   2874 N N   . LEU B 1 111 ? 104.653 140.093 141.506 1.00 71.84  ? 111 LEU B N   1 
ATOM   2875 C CA  . LEU B 1 111 ? 103.496 139.367 142.024 1.00 71.84  ? 111 LEU B CA  1 
ATOM   2876 C C   . LEU B 1 111 ? 103.972 138.506 143.186 1.00 71.84  ? 111 LEU B C   1 
ATOM   2877 O O   . LEU B 1 111 ? 104.353 137.346 143.019 1.00 71.84  ? 111 LEU B O   1 
ATOM   2878 C CB  . LEU B 1 111 ? 102.848 138.530 140.929 1.00 71.84  ? 111 LEU B CB  1 
ATOM   2879 C CG  . LEU B 1 111 ? 102.616 139.243 139.595 1.00 71.84  ? 111 LEU B CG  1 
ATOM   2880 C CD1 . LEU B 1 111 ? 102.098 138.271 138.546 1.00 71.84  ? 111 LEU B CD1 1 
ATOM   2881 C CD2 . LEU B 1 111 ? 101.656 140.411 139.770 1.00 71.84  ? 111 LEU B CD2 1 
ATOM   2882 N N   . VAL B 1 112 ? 103.955 139.092 144.385 1.00 75.70  ? 112 VAL B N   1 
ATOM   2883 C CA  . VAL B 1 112 ? 104.471 138.404 145.564 1.00 75.70  ? 112 VAL B CA  1 
ATOM   2884 C C   . VAL B 1 112 ? 103.600 137.205 145.916 1.00 75.70  ? 112 VAL B C   1 
ATOM   2885 O O   . VAL B 1 112 ? 104.099 136.173 146.380 1.00 75.70  ? 112 VAL B O   1 
ATOM   2886 C CB  . VAL B 1 112 ? 104.587 139.387 146.743 1.00 75.70  ? 112 VAL B CB  1 
ATOM   2887 C CG1 . VAL B 1 112 ? 105.331 138.744 147.904 1.00 75.70  ? 112 VAL B CG1 1 
ATOM   2888 C CG2 . VAL B 1 112 ? 105.280 140.667 146.301 1.00 75.70  ? 112 VAL B CG2 1 
ATOM   2889 N N   . GLY B 1 113 ? 102.291 137.318 145.705 1.00 73.29  ? 113 GLY B N   1 
ATOM   2890 C CA  . GLY B 1 113 ? 101.369 136.268 146.092 1.00 73.29  ? 113 GLY B CA  1 
ATOM   2891 C C   . GLY B 1 113 ? 101.432 135.022 145.231 1.00 73.29  ? 113 GLY B C   1 
ATOM   2892 O O   . GLY B 1 113 ? 102.458 134.730 144.611 1.00 73.29  ? 113 GLY B O   1 
ATOM   2893 N N   . SER B 1 114 ? 100.324 134.280 145.182 1.00 70.39  ? 114 SER B N   1 
ATOM   2894 C CA  . SER B 1 114 ? 100.272 133.034 144.430 1.00 70.39  ? 114 SER B CA  1 
ATOM   2895 C C   . SER B 1 114 ? 100.376 133.246 142.927 1.00 70.39  ? 114 SER B C   1 
ATOM   2896 O O   . SER B 1 114 ? 100.558 132.269 142.193 1.00 70.39  ? 114 SER B O   1 
ATOM   2897 C CB  . SER B 1 114 ? 98.982  132.278 144.755 1.00 70.39  ? 114 SER B CB  1 
ATOM   2898 O OG  . SER B 1 114 ? 97.841  133.057 144.439 1.00 70.39  ? 114 SER B OG  1 
ATOM   2899 N N   . SER B 1 115 ? 100.264 134.487 142.454 1.00 66.27  ? 115 SER B N   1 
ATOM   2900 C CA  . SER B 1 115 ? 100.356 134.767 141.028 1.00 66.27  ? 115 SER B CA  1 
ATOM   2901 C C   . SER B 1 115 ? 101.755 134.550 140.471 1.00 66.27  ? 115 SER B C   1 
ATOM   2902 O O   . SER B 1 115 ? 101.917 134.548 139.246 1.00 66.27  ? 115 SER B O   1 
ATOM   2903 C CB  . SER B 1 115 ? 99.905  136.200 140.748 1.00 66.27  ? 115 SER B CB  1 
ATOM   2904 O OG  . SER B 1 115 ? 98.619  136.442 141.290 1.00 66.27  ? 115 SER B OG  1 
ATOM   2905 N N   . MET B 1 116 ? 102.764 134.377 141.328 1.00 62.48  ? 116 MET B N   1 
ATOM   2906 C CA  . MET B 1 116 ? 104.113 134.117 140.835 1.00 62.48  ? 116 MET B CA  1 
ATOM   2907 C C   . MET B 1 116 ? 104.179 132.797 140.079 1.00 62.48  ? 116 MET B C   1 
ATOM   2908 O O   . MET B 1 116 ? 104.788 132.716 139.004 1.00 62.48  ? 116 MET B O   1 
ATOM   2909 C CB  . MET B 1 116 ? 105.101 134.117 142.001 1.00 62.48  ? 116 MET B CB  1 
ATOM   2910 C CG  . MET B 1 116 ? 106.546 133.916 141.592 1.00 62.48  ? 116 MET B CG  1 
ATOM   2911 S SD  . MET B 1 116 ? 107.039 134.988 140.234 1.00 62.48  ? 116 MET B SD  1 
ATOM   2912 C CE  . MET B 1 116 ? 108.141 136.111 141.086 1.00 62.48  ? 116 MET B CE  1 
ATOM   2913 N N   . GLU B 1 117 ? 103.551 131.752 140.620 1.00 58.64  ? 117 GLU B N   1 
ATOM   2914 C CA  . GLU B 1 117 ? 103.503 130.476 139.917 1.00 58.64  ? 117 GLU B CA  1 
ATOM   2915 C C   . GLU B 1 117 ? 102.762 130.612 138.596 1.00 58.64  ? 117 GLU B C   1 
ATOM   2916 O O   . GLU B 1 117 ? 103.215 130.101 137.564 1.00 58.64  ? 117 GLU B O   1 
ATOM   2917 C CB  . GLU B 1 117 ? 102.847 129.414 140.797 1.00 58.64  ? 117 GLU B CB  1 
ATOM   2918 C CG  . GLU B 1 117 ? 103.481 129.269 142.165 1.00 58.64  ? 117 GLU B CG  1 
ATOM   2919 C CD  . GLU B 1 117 ? 102.757 128.266 143.036 1.00 58.64  ? 117 GLU B CD  1 
ATOM   2920 O OE1 . GLU B 1 117 ? 101.774 127.661 142.558 1.00 58.64  ? 117 GLU B OE1 1 
ATOM   2921 O OE2 . GLU B 1 117 ? 103.169 128.080 144.200 1.00 58.64  ? 117 GLU B OE2 1 
ATOM   2922 N N   . THR B 1 118 ? 101.621 131.304 138.608 1.00 54.22  ? 118 THR B N   1 
ATOM   2923 C CA  . THR B 1 118 ? 100.895 131.558 137.371 1.00 54.22  ? 118 THR B CA  1 
ATOM   2924 C C   . THR B 1 118 ? 101.720 132.409 136.419 1.00 54.22  ? 118 THR B C   1 
ATOM   2925 O O   . THR B 1 118 ? 101.659 132.216 135.200 1.00 54.22  ? 118 THR B O   1 
ATOM   2926 C CB  . THR B 1 118 ? 99.558  132.233 137.677 1.00 54.22  ? 118 THR B CB  1 
ATOM   2927 O OG1 . THR B 1 118 ? 98.750  131.353 138.468 1.00 54.22  ? 118 THR B OG1 1 
ATOM   2928 C CG2 . THR B 1 118 ? 98.814  132.563 136.392 1.00 54.22  ? 118 THR B CG2 1 
ATOM   2929 N N   . LEU B 1 119 ? 102.517 133.334 136.958 1.00 54.05  ? 119 LEU B N   1 
ATOM   2930 C CA  . LEU B 1 119 ? 103.381 134.154 136.117 1.00 54.05  ? 119 LEU B CA  1 
ATOM   2931 C C   . LEU B 1 119 ? 104.392 133.295 135.373 1.00 54.05  ? 119 LEU B C   1 
ATOM   2932 O O   . LEU B 1 119 ? 104.528 133.397 134.148 1.00 54.05  ? 119 LEU B O   1 
ATOM   2933 C CB  . LEU B 1 119 ? 104.095 135.201 136.967 1.00 54.05  ? 119 LEU B CB  1 
ATOM   2934 C CG  . LEU B 1 119 ? 105.005 136.169 136.216 1.00 54.05  ? 119 LEU B CG  1 
ATOM   2935 C CD1 . LEU B 1 119 ? 104.256 136.789 135.052 1.00 54.05  ? 119 LEU B CD1 1 
ATOM   2936 C CD2 . LEU B 1 119 ? 105.526 137.240 137.156 1.00 54.05  ? 119 LEU B CD2 1 
ATOM   2937 N N   . ILE B 1 120 ? 105.109 132.435 136.100 1.00 48.94  ? 120 ILE B N   1 
ATOM   2938 C CA  . ILE B 1 120 ? 106.093 131.562 135.462 1.00 48.94  ? 120 ILE B CA  1 
ATOM   2939 C C   . ILE B 1 120 ? 105.416 130.626 134.471 1.00 48.94  ? 120 ILE B C   1 
ATOM   2940 O O   . ILE B 1 120 ? 105.925 130.396 133.365 1.00 48.94  ? 120 ILE B O   1 
ATOM   2941 C CB  . ILE B 1 120 ? 106.892 130.782 136.520 1.00 48.94  ? 120 ILE B CB  1 
ATOM   2942 C CG1 . ILE B 1 120 ? 107.425 131.731 137.589 1.00 48.94  ? 120 ILE B CG1 1 
ATOM   2943 C CG2 . ILE B 1 120 ? 108.043 130.047 135.871 1.00 48.94  ? 120 ILE B CG2 1 
ATOM   2944 C CD1 . ILE B 1 120 ? 108.281 131.058 138.622 1.00 48.94  ? 120 ILE B CD1 1 
ATOM   2945 N N   . GLN B 1 121 ? 104.271 130.058 134.853 1.00 47.87  ? 121 GLN B N   1 
ATOM   2946 C CA  . GLN B 1 121 ? 103.574 129.126 133.974 1.00 47.87  ? 121 GLN B CA  1 
ATOM   2947 C C   . GLN B 1 121 ? 103.181 129.798 132.666 1.00 47.87  ? 121 GLN B C   1 
ATOM   2948 O O   . GLN B 1 121 ? 103.449 129.271 131.580 1.00 47.87  ? 121 GLN B O   1 
ATOM   2949 C CB  . GLN B 1 121 ? 102.342 128.565 134.682 1.00 47.87  ? 121 GLN B CB  1 
ATOM   2950 C CG  . GLN B 1 121 ? 102.541 127.188 135.276 1.00 47.87  ? 121 GLN B CG  1 
ATOM   2951 C CD  . GLN B 1 121 ? 101.266 126.618 135.858 1.00 47.87  ? 121 GLN B CD  1 
ATOM   2952 O OE1 . GLN B 1 121 ? 100.297 127.341 136.087 1.00 47.87  ? 121 GLN B OE1 1 
ATOM   2953 N NE2 . GLN B 1 121 ? 101.261 125.313 136.105 1.00 47.87  ? 121 GLN B NE2 1 
ATOM   2954 N N   . THR B 1 122 ? 102.550 130.972 132.753 1.00 45.97  ? 122 THR B N   1 
ATOM   2955 C CA  . THR B 1 122 ? 102.124 131.682 131.554 1.00 45.97  ? 122 THR B CA  1 
ATOM   2956 C C   . THR B 1 122 ? 103.319 132.109 130.717 1.00 45.97  ? 122 THR B C   1 
ATOM   2957 O O   . THR B 1 122 ? 103.284 132.030 129.485 1.00 45.97  ? 122 THR B O   1 
ATOM   2958 C CB  . THR B 1 122 ? 101.285 132.895 131.942 1.00 45.97  ? 122 THR B CB  1 
ATOM   2959 O OG1 . THR B 1 122 ? 100.292 132.502 132.895 1.00 45.97  ? 122 THR B OG1 1 
ATOM   2960 C CG2 . THR B 1 122 ? 100.598 133.480 130.719 1.00 45.97  ? 122 THR B CG2 1 
ATOM   2961 N N   . ARG B 1 123 ? 104.393 132.551 131.374 1.00 44.51  ? 123 ARG B N   1 
ATOM   2962 C CA  . ARG B 1 123 ? 105.593 132.985 130.670 1.00 44.51  ? 123 ARG B CA  1 
ATOM   2963 C C   . ARG B 1 123 ? 106.200 131.850 129.851 1.00 44.51  ? 123 ARG B C   1 
ATOM   2964 O O   . ARG B 1 123 ? 106.472 132.004 128.651 1.00 44.51  ? 123 ARG B O   1 
ATOM   2965 C CB  . ARG B 1 123 ? 106.574 133.535 131.704 1.00 44.51  ? 123 ARG B CB  1 
ATOM   2966 C CG  . ARG B 1 123 ? 107.931 133.911 131.212 1.00 44.51  ? 123 ARG B CG  1 
ATOM   2967 C CD  . ARG B 1 123 ? 108.903 133.892 132.379 1.00 44.51  ? 123 ARG B CD  1 
ATOM   2968 N NE  . ARG B 1 123 ? 108.500 134.768 133.470 1.00 44.51  ? 123 ARG B NE  1 
ATOM   2969 C CZ  . ARG B 1 123 ? 108.895 134.624 134.727 1.00 44.51  ? 123 ARG B CZ  1 
ATOM   2970 N NH1 . ARG B 1 123 ? 109.729 133.662 135.084 1.00 44.51  ? 123 ARG B NH1 1 
ATOM   2971 N NH2 . ARG B 1 123 ? 108.452 135.476 135.648 1.00 44.51  ? 123 ARG B NH2 1 
ATOM   2972 N N   . LEU B 1 124 ? 106.390 130.686 130.475 1.00 43.02  ? 124 LEU B N   1 
ATOM   2973 C CA  . LEU B 1 124 ? 106.953 129.551 129.750 1.00 43.02  ? 124 LEU B CA  1 
ATOM   2974 C C   . LEU B 1 124 ? 105.991 129.042 128.683 1.00 43.02  ? 124 LEU B C   1 
ATOM   2975 O O   . LEU B 1 124 ? 106.420 128.609 127.603 1.00 43.02  ? 124 LEU B O   1 
ATOM   2976 C CB  . LEU B 1 124 ? 107.318 128.435 130.725 1.00 43.02  ? 124 LEU B CB  1 
ATOM   2977 C CG  . LEU B 1 124 ? 108.361 128.801 131.780 1.00 43.02  ? 124 LEU B CG  1 
ATOM   2978 C CD1 . LEU B 1 124 ? 108.719 127.593 132.622 1.00 43.02  ? 124 LEU B CD1 1 
ATOM   2979 C CD2 . LEU B 1 124 ? 109.590 129.388 131.126 1.00 43.02  ? 124 LEU B CD2 1 
ATOM   2980 N N   . SER B 1 125 ? 104.684 129.089 128.961 1.00 41.76  ? 125 SER B N   1 
ATOM   2981 C CA  . SER B 1 125 ? 103.704 128.656 127.974 1.00 41.76  ? 125 SER B CA  1 
ATOM   2982 C C   . SER B 1 125 ? 103.754 129.535 126.735 1.00 41.76  ? 125 SER B C   1 
ATOM   2983 O O   . SER B 1 125 ? 103.679 129.032 125.607 1.00 41.76  ? 125 SER B O   1 
ATOM   2984 C CB  . SER B 1 125 ? 102.307 128.670 128.587 1.00 41.76  ? 125 SER B CB  1 
ATOM   2985 O OG  . SER B 1 125 ? 102.220 127.762 129.670 1.00 41.76  ? 125 SER B OG  1 
ATOM   2986 N N   . MET B 1 126 ? 103.885 130.851 126.919 1.00 41.07  ? 126 MET B N   1 
ATOM   2987 C CA  . MET B 1 126 ? 103.987 131.719 125.755 1.00 41.07  ? 126 MET B CA  1 
ATOM   2988 C C   . MET B 1 126 ? 105.314 131.524 125.042 1.00 41.07  ? 126 MET B C   1 
ATOM   2989 O O   . MET B 1 126 ? 105.366 131.642 123.818 1.00 41.07  ? 126 MET B O   1 
ATOM   2990 C CB  . MET B 1 126 ? 103.790 133.192 126.108 1.00 41.07  ? 126 MET B CB  1 
ATOM   2991 C CG  . MET B 1 126 ? 102.357 133.572 126.419 1.00 41.07  ? 126 MET B CG  1 
ATOM   2992 S SD  . MET B 1 126 ? 102.216 135.122 127.324 1.00 41.07  ? 126 MET B SD  1 
ATOM   2993 C CE  . MET B 1 126 ? 103.491 134.936 128.554 1.00 41.07  ? 126 MET B CE  1 
ATOM   2994 N N   . LEU B 1 127 ? 106.390 131.217 125.770 1.00 42.84  ? 127 LEU B N   1 
ATOM   2995 C CA  . LEU B 1 127 ? 107.631 130.858 125.086 1.00 42.84  ? 127 LEU B CA  1 
ATOM   2996 C C   . LEU B 1 127 ? 107.422 129.674 124.153 1.00 42.84  ? 127 LEU B C   1 
ATOM   2997 O O   . LEU B 1 127 ? 107.814 129.715 122.980 1.00 42.84  ? 127 LEU B O   1 
ATOM   2998 C CB  . LEU B 1 127 ? 108.728 130.515 126.091 1.00 42.84  ? 127 LEU B CB  1 
ATOM   2999 C CG  . LEU B 1 127 ? 109.495 131.587 126.842 1.00 42.84  ? 127 LEU B CG  1 
ATOM   3000 C CD1 . LEU B 1 127 ? 110.368 130.898 127.865 1.00 42.84  ? 127 LEU B CD1 1 
ATOM   3001 C CD2 . LEU B 1 127 ? 110.333 132.361 125.856 1.00 42.84  ? 127 LEU B CD2 1 
ATOM   3002 N N   . CYS B 1 128 ? 106.804 128.607 124.660 1.00 42.78  ? 128 CYS B N   1 
ATOM   3003 C CA  . CYS B 1 128 ? 106.607 127.414 123.840 1.00 42.78  ? 128 CYS B CA  1 
ATOM   3004 C C   . CYS B 1 128 ? 105.695 127.701 122.652 1.00 42.78  ? 128 CYS B C   1 
ATOM   3005 O O   . CYS B 1 128 ? 105.994 127.314 121.512 1.00 42.78  ? 128 CYS B O   1 
ATOM   3006 C CB  . CYS B 1 128 ? 106.038 126.282 124.691 1.00 42.78  ? 128 CYS B CB  1 
ATOM   3007 S SG  . CYS B 1 128 ? 105.470 124.862 123.730 1.00 42.78  ? 128 CYS B SG  1 
ATOM   3008 N N   . ILE B 1 129 ? 104.575 128.387 122.899 1.00 39.39  ? 129 ILE B N   1 
ATOM   3009 C CA  . ILE B 1 129 ? 103.631 128.682 121.826 1.00 39.39  ? 129 ILE B CA  1 
ATOM   3010 C C   . ILE B 1 129 ? 104.274 129.578 120.774 1.00 39.39  ? 129 ILE B C   1 
ATOM   3011 O O   . ILE B 1 129 ? 104.098 129.365 119.569 1.00 39.39  ? 129 ILE B O   1 
ATOM   3012 C CB  . ILE B 1 129 ? 102.347 129.306 122.400 1.00 39.39  ? 129 ILE B CB  1 
ATOM   3013 C CG1 . ILE B 1 129 ? 101.619 128.299 123.287 1.00 39.39  ? 129 ILE B CG1 1 
ATOM   3014 C CG2 . ILE B 1 129 ? 101.433 129.770 121.284 1.00 39.39  ? 129 ILE B CG2 1 
ATOM   3015 C CD1 . ILE B 1 129 ? 101.332 126.984 122.606 1.00 39.39  ? 129 ILE B CD1 1 
ATOM   3016 N N   . GLY B 1 130 ? 105.040 130.581 121.206 1.00 38.75  ? 130 GLY B N   1 
ATOM   3017 C CA  . GLY B 1 130 ? 105.694 131.463 120.259 1.00 38.75  ? 130 GLY B CA  1 
ATOM   3018 C C   . GLY B 1 130 ? 106.760 130.770 119.437 1.00 38.75  ? 130 GLY B C   1 
ATOM   3019 O O   . GLY B 1 130 ? 106.874 131.007 118.233 1.00 38.75  ? 130 GLY B O   1 
ATOM   3020 N N   . THR B 1 131 ? 107.557 129.906 120.068 1.00 39.27  ? 131 THR B N   1 
ATOM   3021 C CA  . THR B 1 131 ? 108.555 129.159 119.310 1.00 39.27  ? 131 THR B CA  1 
ATOM   3022 C C   . THR B 1 131 ? 107.894 128.261 118.276 1.00 39.27  ? 131 THR B C   1 
ATOM   3023 O O   . THR B 1 131 ? 108.340 128.195 117.122 1.00 39.27  ? 131 THR B O   1 
ATOM   3024 C CB  . THR B 1 131 ? 109.430 128.337 120.252 1.00 39.27  ? 131 THR B CB  1 
ATOM   3025 O OG1 . THR B 1 131 ? 110.101 129.212 121.168 1.00 39.27  ? 131 THR B OG1 1 
ATOM   3026 C CG2 . THR B 1 131 ? 110.463 127.549 119.466 1.00 39.27  ? 131 THR B CG2 1 
ATOM   3027 N N   . SER B 1 132 ? 106.819 127.570 118.667 1.00 38.86  ? 132 SER B N   1 
ATOM   3028 C CA  . SER B 1 132 ? 106.100 126.728 117.715 1.00 38.86  ? 132 SER B CA  1 
ATOM   3029 C C   . SER B 1 132 ? 105.533 127.553 116.568 1.00 38.86  ? 132 SER B C   1 
ATOM   3030 O O   . SER B 1 132 ? 105.661 127.177 115.396 1.00 38.86  ? 132 SER B O   1 
ATOM   3031 C CB  . SER B 1 132 ? 104.985 125.973 118.433 1.00 38.86  ? 132 SER B CB  1 
ATOM   3032 O OG  . SER B 1 132 ? 105.516 125.091 119.404 1.00 38.86  ? 132 SER B OG  1 
ATOM   3033 N N   . LEU B 1 133 ? 104.920 128.694 116.885 1.00 37.26  ? 133 LEU B N   1 
ATOM   3034 C CA  . LEU B 1 133 ? 104.287 129.527 115.874 1.00 37.26  ? 133 LEU B CA  1 
ATOM   3035 C C   . LEU B 1 133 ? 105.297 130.233 114.981 1.00 37.26  ? 133 LEU B C   1 
ATOM   3036 O O   . LEU B 1 133 ? 104.934 130.665 113.883 1.00 37.26  ? 133 LEU B O   1 
ATOM   3037 C CB  . LEU B 1 133 ? 103.379 130.554 116.545 1.00 37.26  ? 133 LEU B CB  1 
ATOM   3038 C CG  . LEU B 1 133 ? 101.905 130.176 116.655 1.00 37.26  ? 133 LEU B CG  1 
ATOM   3039 C CD1 . LEU B 1 133 ? 101.134 131.238 117.406 1.00 37.26  ? 133 LEU B CD1 1 
ATOM   3040 C CD2 . LEU B 1 133 ? 101.322 129.978 115.280 1.00 37.26  ? 133 LEU B CD2 1 
ATOM   3041 N N   . VAL B 1 134 ? 106.541 130.387 115.433 1.00 39.60  ? 134 VAL B N   1 
ATOM   3042 C CA  . VAL B 1 134 ? 107.568 130.972 114.577 1.00 39.60  ? 134 VAL B CA  1 
ATOM   3043 C C   . VAL B 1 134 ? 108.202 129.912 113.686 1.00 39.60  ? 134 VAL B C   1 
ATOM   3044 O O   . VAL B 1 134 ? 108.423 130.144 112.493 1.00 39.60  ? 134 VAL B O   1 
ATOM   3045 C CB  . VAL B 1 134 ? 108.620 131.701 115.432 1.00 39.60  ? 134 VAL B CB  1 
ATOM   3046 C CG1 . VAL B 1 134 ? 109.833 132.050 114.599 1.00 39.60  ? 134 VAL B CG1 1 
ATOM   3047 C CG2 . VAL B 1 134 ? 108.027 132.960 116.036 1.00 39.60  ? 134 VAL B CG2 1 
ATOM   3048 N N   . PHE B 1 135 ? 108.495 128.735 114.233 1.00 41.15  ? 135 PHE B N   1 
ATOM   3049 C CA  . PHE B 1 135 ? 109.247 127.730 113.495 1.00 41.15  ? 135 PHE B CA  1 
ATOM   3050 C C   . PHE B 1 135 ? 108.372 126.709 112.780 1.00 41.15  ? 135 PHE B C   1 
ATOM   3051 O O   . PHE B 1 135 ? 108.911 125.785 112.166 1.00 41.15  ? 135 PHE B O   1 
ATOM   3052 C CB  . PHE B 1 135 ? 110.222 127.012 114.430 1.00 41.15  ? 135 PHE B CB  1 
ATOM   3053 C CG  . PHE B 1 135 ? 111.606 127.586 114.402 1.00 41.15  ? 135 PHE B CG  1 
ATOM   3054 C CD1 . PHE B 1 135 ? 112.411 127.429 113.288 1.00 41.15  ? 135 PHE B CD1 1 
ATOM   3055 C CD2 . PHE B 1 135 ? 112.096 128.300 115.480 1.00 41.15  ? 135 PHE B CD2 1 
ATOM   3056 C CE1 . PHE B 1 135 ? 113.681 127.963 113.254 1.00 41.15  ? 135 PHE B CE1 1 
ATOM   3057 C CE2 . PHE B 1 135 ? 113.367 128.836 115.452 1.00 41.15  ? 135 PHE B CE2 1 
ATOM   3058 C CZ  . PHE B 1 135 ? 114.160 128.667 114.337 1.00 41.15  ? 135 PHE B CZ  1 
ATOM   3059 N N   . GLY B 1 136 ? 107.052 126.837 112.844 1.00 38.80  ? 136 GLY B N   1 
ATOM   3060 C CA  . GLY B 1 136 ? 106.181 126.008 112.046 1.00 38.80  ? 136 GLY B CA  1 
ATOM   3061 C C   . GLY B 1 136 ? 106.003 126.505 110.625 1.00 38.80  ? 136 GLY B C   1 
ATOM   3062 O O   . GLY B 1 136 ? 106.209 125.765 109.656 1.00 38.80  ? 136 GLY B O   1 
ATOM   3063 N N   . PRO B 1 137 ? 105.580 127.766 110.473 1.00 38.70  ? 137 PRO B N   1 
ATOM   3064 C CA  . PRO B 1 137 ? 105.318 128.289 109.122 1.00 38.70  ? 137 PRO B CA  1 
ATOM   3065 C C   . PRO B 1 137 ? 106.512 128.235 108.189 1.00 38.70  ? 137 PRO B C   1 
ATOM   3066 O O   . PRO B 1 137 ? 106.334 128.002 106.987 1.00 38.70  ? 137 PRO B O   1 
ATOM   3067 C CB  . PRO B 1 137 ? 104.881 129.730 109.402 1.00 38.70  ? 137 PRO B CB  1 
ATOM   3068 C CG  . PRO B 1 137 ? 104.247 129.652 110.730 1.00 38.70  ? 137 PRO B CG  1 
ATOM   3069 C CD  . PRO B 1 137 ? 105.065 128.677 111.509 1.00 38.70  ? 137 PRO B CD  1 
ATOM   3070 N N   . ILE B 1 138 ? 107.726 128.452 108.697 1.00 40.36  ? 138 ILE B N   1 
ATOM   3071 C CA  . ILE B 1 138 ? 108.898 128.402 107.829 1.00 40.36  ? 138 ILE B CA  1 
ATOM   3072 C C   . ILE B 1 138 ? 109.085 126.995 107.279 1.00 40.36  ? 138 ILE B C   1 
ATOM   3073 O O   . ILE B 1 138 ? 109.363 126.806 106.087 1.00 40.36  ? 138 ILE B O   1 
ATOM   3074 C CB  . ILE B 1 138 ? 110.150 128.889 108.580 1.00 40.36  ? 138 ILE B CB  1 
ATOM   3075 C CG1 . ILE B 1 138 ? 109.816 130.082 109.469 1.00 40.36  ? 138 ILE B CG1 1 
ATOM   3076 C CG2 . ILE B 1 138 ? 111.235 129.276 107.598 1.00 40.36  ? 138 ILE B CG2 1 
ATOM   3077 C CD1 . ILE B 1 138 ? 110.966 130.519 110.339 1.00 40.36  ? 138 ILE B CD1 1 
ATOM   3078 N N   . LEU B 1 139 ? 108.937 125.986 108.137 1.00 39.32  ? 139 LEU B N   1 
ATOM   3079 C CA  . LEU B 1 139 ? 109.061 124.607 107.683 1.00 39.32  ? 139 LEU B CA  1 
ATOM   3080 C C   . LEU B 1 139 ? 107.942 124.248 106.717 1.00 39.32  ? 139 LEU B C   1 
ATOM   3081 O O   . LEU B 1 139 ? 108.159 123.496 105.762 1.00 39.32  ? 139 LEU B O   1 
ATOM   3082 C CB  . LEU B 1 139 ? 109.064 123.650 108.872 1.00 39.32  ? 139 LEU B CB  1 
ATOM   3083 C CG  . LEU B 1 139 ? 110.098 123.874 109.973 1.00 39.32  ? 139 LEU B CG  1 
ATOM   3084 C CD1 . LEU B 1 139 ? 110.332 122.586 110.733 1.00 39.32  ? 139 LEU B CD1 1 
ATOM   3085 C CD2 . LEU B 1 139 ? 111.403 124.416 109.420 1.00 39.32  ? 139 LEU B CD2 1 
ATOM   3086 N N   . GLY B 1 140 ? 106.737 124.771 106.950 1.00 40.92  ? 140 GLY B N   1 
ATOM   3087 C CA  . GLY B 1 140 ? 105.657 124.555 106.000 1.00 40.92  ? 140 GLY B CA  1 
ATOM   3088 C C   . GLY B 1 140 ? 105.968 125.130 104.631 1.00 40.92  ? 140 GLY B C   1 
ATOM   3089 O O   . GLY B 1 140 ? 105.750 124.483 103.604 1.00 40.92  ? 140 GLY B O   1 
ATOM   3090 N N   . LYS B 1 141 ? 106.482 126.362 104.602 1.00 41.21  ? 141 LYS B N   1 
ATOM   3091 C CA  . LYS B 1 141 ? 106.860 126.984 103.337 1.00 41.21  ? 141 LYS B CA  1 
ATOM   3092 C C   . LYS B 1 141 ? 107.947 126.180 102.635 1.00 41.21  ? 141 LYS B C   1 
ATOM   3093 O O   . LYS B 1 141 ? 107.892 125.974 101.415 1.00 41.21  ? 141 LYS B O   1 
ATOM   3094 C CB  . LYS B 1 141 ? 107.326 128.418 103.580 1.00 41.21  ? 141 LYS B CB  1 
ATOM   3095 C CG  . LYS B 1 141 ? 106.225 129.448 103.519 1.00 41.21  ? 141 LYS B CG  1 
ATOM   3096 C CD  . LYS B 1 141 ? 106.719 130.801 103.991 1.00 41.21  ? 141 LYS B CD  1 
ATOM   3097 C CE  . LYS B 1 141 ? 107.107 130.768 105.459 1.00 41.21  ? 141 LYS B CE  1 
ATOM   3098 N NZ  . LYS B 1 141 ? 107.264 132.136 106.025 1.00 41.21  ? 141 LYS B NZ  1 
ATOM   3099 N N   . SER B 1 142 ? 108.948 125.723 103.390 1.00 40.34  ? 142 SER B N   1 
ATOM   3100 C CA  . SER B 1 142 ? 110.025 124.942 102.793 1.00 40.34  ? 142 SER B CA  1 
ATOM   3101 C C   . SER B 1 142 ? 109.506 123.617 102.249 1.00 40.34  ? 142 SER B C   1 
ATOM   3102 O O   . SER B 1 142 ? 109.937 123.168 101.181 1.00 40.34  ? 142 SER B O   1 
ATOM   3103 C CB  . SER B 1 142 ? 111.134 124.711 103.814 1.00 40.34  ? 142 SER B CB  1 
ATOM   3104 O OG  . SER B 1 142 ? 111.982 125.841 103.898 1.00 40.34  ? 142 SER B OG  1 
ATOM   3105 N N   . TRP B 1 143 ? 108.586 122.974 102.970 1.00 41.05  ? 143 TRP B N   1 
ATOM   3106 C CA  . TRP B 1 143 ? 108.008 121.724 102.492 1.00 41.05  ? 143 TRP B CA  1 
ATOM   3107 C C   . TRP B 1 143 ? 107.206 121.953 101.218 1.00 41.05  ? 143 TRP B C   1 
ATOM   3108 O O   . TRP B 1 143 ? 107.268 121.143 100.284 1.00 41.05  ? 143 TRP B O   1 
ATOM   3109 C CB  . TRP B 1 143 ? 107.136 121.098 103.577 1.00 41.05  ? 143 TRP B CB  1 
ATOM   3110 C CG  . TRP B 1 143 ? 106.530 119.792 103.182 1.00 41.05  ? 143 TRP B CG  1 
ATOM   3111 C CD1 . TRP B 1 143 ? 107.188 118.690 102.732 1.00 41.05  ? 143 TRP B CD1 1 
ATOM   3112 C CD2 . TRP B 1 143 ? 105.141 119.448 103.205 1.00 41.05  ? 143 TRP B CD2 1 
ATOM   3113 N NE1 . TRP B 1 143 ? 106.298 117.680 102.470 1.00 41.05  ? 143 TRP B NE1 1 
ATOM   3114 C CE2 . TRP B 1 143 ? 105.033 118.121 102.752 1.00 41.05  ? 143 TRP B CE2 1 
ATOM   3115 C CE3 . TRP B 1 143 ? 103.977 120.136 103.561 1.00 41.05  ? 143 TRP B CE3 1 
ATOM   3116 C CZ2 . TRP B 1 143 ? 103.811 117.466 102.647 1.00 41.05  ? 143 TRP B CZ2 1 
ATOM   3117 C CZ3 . TRP B 1 143 ? 102.764 119.484 103.457 1.00 41.05  ? 143 TRP B CZ3 1 
ATOM   3118 C CH2 . TRP B 1 143 ? 102.690 118.162 103.003 1.00 41.05  ? 143 TRP B CH2 1 
ATOM   3119 N N   . ARG B 1 144 ? 106.390 122.982 101.126 1.00 43.01  ? 144 ARG B N   1 
ATOM   3120 C CA  . ARG B 1 144 ? 105.745 123.200 99.832  1.00 43.01  ? 144 ARG B CA  1 
ATOM   3121 C C   . ARG B 1 144 ? 106.811 123.393 98.785  1.00 43.01  ? 144 ARG B C   1 
ATOM   3122 O O   . ARG B 1 144 ? 106.823 122.695 97.790  1.00 43.01  ? 144 ARG B O   1 
ATOM   3123 C CB  . ARG B 1 144 ? 104.801 124.369 99.836  1.00 43.01  ? 144 ARG B CB  1 
ATOM   3124 C CG  . ARG B 1 144 ? 104.281 124.739 98.464  1.00 43.01  ? 144 ARG B CG  1 
ATOM   3125 C CD  . ARG B 1 144 ? 103.039 125.597 98.581  1.00 43.01  ? 144 ARG B CD  1 
ATOM   3126 N NE  . ARG B 1 144 ? 103.248 126.745 99.449  1.00 43.01  ? 144 ARG B NE  1 
ATOM   3127 C CZ  . ARG B 1 144 ? 102.276 127.549 99.856  1.00 43.01  ? 144 ARG B CZ  1 
ATOM   3128 N NH1 . ARG B 1 144 ? 101.027 127.321 99.478  1.00 43.01  ? 144 ARG B NH1 1 
ATOM   3129 N NH2 . ARG B 1 144 ? 102.547 128.575 100.645 1.00 43.01  ? 144 ARG B NH2 1 
ATOM   3130 N N   . LEU B 1 145 ? 107.736 124.315 99.001  1.00 40.88  ? 145 LEU B N   1 
ATOM   3131 C CA  . LEU B 1 145 ? 108.711 124.534 97.938  1.00 40.88  ? 145 LEU B CA  1 
ATOM   3132 C C   . LEU B 1 145 ? 109.328 123.223 97.471  1.00 40.88  ? 145 LEU B C   1 
ATOM   3133 O O   . LEU B 1 145 ? 109.471 122.988 96.263  1.00 40.88  ? 145 LEU B O   1 
ATOM   3134 C CB  . LEU B 1 145 ? 109.784 125.506 98.429  1.00 40.88  ? 145 LEU B CB  1 
ATOM   3135 C CG  . LEU B 1 145 ? 110.840 126.054 97.472  1.00 40.88  ? 145 LEU B CG  1 
ATOM   3136 C CD1 . LEU B 1 145 ? 111.312 127.397 97.977  1.00 40.88  ? 145 LEU B CD1 1 
ATOM   3137 C CD2 . LEU B 1 145 ? 112.023 125.112 97.350  1.00 40.88  ? 145 LEU B CD2 1 
ATOM   3138 N N   . TYR B 1 146 ? 109.690 122.352 98.413  1.00 41.47  ? 146 TYR B N   1 
ATOM   3139 C CA  . TYR B 1 146 ? 110.266 121.065 98.050  1.00 41.47  ? 146 TYR B CA  1 
ATOM   3140 C C   . TYR B 1 146 ? 109.300 120.260 97.196  1.00 41.47  ? 146 TYR B C   1 
ATOM   3141 O O   . TYR B 1 146 ? 109.671 119.749 96.134  1.00 41.47  ? 146 TYR B O   1 
ATOM   3142 C CB  . TYR B 1 146 ? 110.652 120.290 99.308  1.00 41.47  ? 146 TYR B CB  1 
ATOM   3143 C CG  . TYR B 1 146 ? 110.977 118.837 99.063  1.00 41.47  ? 146 TYR B CG  1 
ATOM   3144 C CD1 . TYR B 1 146 ? 111.937 118.469 98.133  1.00 41.47  ? 146 TYR B CD1 1 
ATOM   3145 C CD2 . TYR B 1 146 ? 110.335 117.835 99.769  1.00 41.47  ? 146 TYR B CD2 1 
ATOM   3146 C CE1 . TYR B 1 146 ? 112.242 117.146 97.909  1.00 41.47  ? 146 TYR B CE1 1 
ATOM   3147 C CE2 . TYR B 1 146 ? 110.632 116.509 99.551  1.00 41.47  ? 146 TYR B CE2 1 
ATOM   3148 C CZ  . TYR B 1 146 ? 111.586 116.169 98.620  1.00 41.47  ? 146 TYR B CZ  1 
ATOM   3149 O OH  . TYR B 1 146 ? 111.886 114.845 98.400  1.00 41.47  ? 146 TYR B OH  1 
ATOM   3150 N N   . LYS B 1 147 ? 108.038 120.171 97.626  1.00 44.29  ? 147 LYS B N   1 
ATOM   3151 C CA  . LYS B 1 147 ? 107.073 119.367 96.884  1.00 44.29  ? 147 LYS B CA  1 
ATOM   3152 C C   . LYS B 1 147 ? 106.730 119.988 95.536  1.00 44.29  ? 147 LYS B C   1 
ATOM   3153 O O   . LYS B 1 147 ? 106.454 119.261 94.578  1.00 44.29  ? 147 LYS B O   1 
ATOM   3154 C CB  . LYS B 1 147 ? 105.804 119.167 97.709  1.00 44.29  ? 147 LYS B CB  1 
ATOM   3155 C CG  . LYS B 1 147 ? 106.019 118.468 99.036  1.00 44.29  ? 147 LYS B CG  1 
ATOM   3156 C CD  . LYS B 1 147 ? 106.741 117.143 98.863  1.00 44.29  ? 147 LYS B CD  1 
ATOM   3157 C CE  . LYS B 1 147 ? 105.936 116.177 98.007  1.00 44.29  ? 147 LYS B CE  1 
ATOM   3158 N NZ  . LYS B 1 147 ? 104.583 115.925 98.576  1.00 44.29  ? 147 LYS B NZ  1 
ATOM   3159 N N   . VAL B 1 148 ? 106.888 121.264 95.321  1.00 43.90  ? 148 VAL B N   1 
ATOM   3160 C CA  . VAL B 1 148 ? 106.566 121.796 94.019  1.00 43.90  ? 148 VAL B CA  1 
ATOM   3161 C C   . VAL B 1 148 ? 107.737 121.847 93.081  1.00 43.90  ? 148 VAL B C   1 
ATOM   3162 O O   . VAL B 1 148 ? 107.568 121.984 91.884  1.00 43.90  ? 148 VAL B O   1 
ATOM   3163 C CB  . VAL B 1 148 ? 105.993 123.201 94.161  1.00 43.90  ? 148 VAL B CB  1 
ATOM   3164 C CG1 . VAL B 1 148 ? 106.988 124.131 94.826  1.00 43.90  ? 148 VAL B CG1 1 
ATOM   3165 C CG2 . VAL B 1 148 ? 105.529 123.751 92.821  1.00 43.90  ? 148 VAL B CG2 1 
ATOM   3166 N N   . PHE B 1 149 ? 108.929 121.735 93.603  1.00 46.02  ? 149 PHE B N   1 
ATOM   3167 C CA  . PHE B 1 149 ? 110.065 121.691 92.739  1.00 46.02  ? 149 PHE B CA  1 
ATOM   3168 C C   . PHE B 1 149 ? 110.616 120.283 92.686  1.00 46.02  ? 149 PHE B C   1 
ATOM   3169 O O   . PHE B 1 149 ? 111.678 120.077 92.116  1.00 46.02  ? 149 PHE B O   1 
ATOM   3170 C CB  . PHE B 1 149 ? 111.154 122.699 93.128  1.00 46.02  ? 149 PHE B CB  1 
ATOM   3171 C CG  . PHE B 1 149 ? 110.812 124.150 92.816  1.00 46.02  ? 149 PHE B CG  1 
ATOM   3172 C CD1 . PHE B 1 149 ? 109.722 124.746 93.420  1.00 46.02  ? 149 PHE B CD1 1 
ATOM   3173 C CD2 . PHE B 1 149 ? 111.591 124.928 91.937  1.00 46.02  ? 149 PHE B CD2 1 
ATOM   3174 C CE1 . PHE B 1 149 ? 109.394 126.063 93.158  1.00 46.02  ? 149 PHE B CE1 1 
ATOM   3175 C CE2 . PHE B 1 149 ? 111.262 126.243 91.677  1.00 46.02  ? 149 PHE B CE2 1 
ATOM   3176 C CZ  . PHE B 1 149 ? 110.163 126.811 92.289  1.00 46.02  ? 149 PHE B CZ  1 
ATOM   3177 N N   . THR B 1 150 ? 109.923 119.298 93.258  1.00 51.30  ? 150 THR B N   1 
ATOM   3178 C CA  . THR B 1 150 ? 110.390 117.929 93.067  1.00 51.30  ? 150 THR B CA  1 
ATOM   3179 C C   . THR B 1 150 ? 109.322 116.972 92.560  1.00 51.30  ? 150 THR B C   1 
ATOM   3180 O O   . THR B 1 150 ? 109.649 115.813 92.284  1.00 51.30  ? 150 THR B O   1 
ATOM   3181 C CB  . THR B 1 150 ? 110.963 117.350 94.369  1.00 51.30  ? 150 THR B CB  1 
ATOM   3182 O OG1 . THR B 1 150 ? 111.797 116.230 94.055  1.00 51.30  ? 150 THR B OG1 1 
ATOM   3183 C CG2 . THR B 1 150 ? 109.838 116.857 95.267  1.00 51.30  ? 150 THR B CG2 1 
ATOM   3184 N N   . GLN B 1 151 ? 108.067 117.403 92.433  1.00 60.13  ? 151 GLN B N   1 
ATOM   3185 C CA  . GLN B 1 151 ? 106.998 116.540 91.934  1.00 60.13  ? 151 GLN B CA  1 
ATOM   3186 C C   . GLN B 1 151 ? 106.788 116.830 90.452  1.00 60.13  ? 151 GLN B C   1 
ATOM   3187 O O   . GLN B 1 151 ? 105.843 117.502 90.043  1.00 60.13  ? 151 GLN B O   1 
ATOM   3188 C CB  . GLN B 1 151 ? 105.718 116.735 92.740  1.00 60.13  ? 151 GLN B CB  1 
ATOM   3189 C CG  . GLN B 1 151 ? 105.797 116.209 94.167  1.00 60.13  ? 151 GLN B CG  1 
ATOM   3190 C CD  . GLN B 1 151 ? 105.993 114.706 94.229  1.00 60.13  ? 151 GLN B CD  1 
ATOM   3191 O OE1 . GLN B 1 151 ? 105.550 113.972 93.345  1.00 60.13  ? 151 GLN B OE1 1 
ATOM   3192 N NE2 . GLN B 1 151 ? 106.661 114.239 95.278  1.00 60.13  ? 151 GLN B NE2 1 
ATOM   3193 N N   . ARG B 1 152 ? 107.700 116.302 89.641  1.00 70.94  ? 152 ARG B N   1 
ATOM   3194 C CA  . ARG B 1 152 ? 107.583 116.325 88.190  1.00 70.94  ? 152 ARG B CA  1 
ATOM   3195 C C   . ARG B 1 152 ? 106.875 115.091 87.648  1.00 70.94  ? 152 ARG B C   1 
ATOM   3196 O O   . ARG B 1 152 ? 106.843 114.891 86.429  1.00 70.94  ? 152 ARG B O   1 
ATOM   3197 C CB  . ARG B 1 152 ? 108.968 116.461 87.545  1.00 70.94  ? 152 ARG B CB  1 
ATOM   3198 C CG  . ARG B 1 152 ? 109.825 115.198 87.582  1.00 70.94  ? 152 ARG B CG  1 
ATOM   3199 C CD  . ARG B 1 152 ? 110.492 114.993 88.934  1.00 70.94  ? 152 ARG B CD  1 
ATOM   3200 N NE  . ARG B 1 152 ? 111.497 113.938 88.892  1.00 70.94  ? 152 ARG B NE  1 
ATOM   3201 C CZ  . ARG B 1 152 ? 112.083 113.418 89.962  1.00 70.94  ? 152 ARG B CZ  1 
ATOM   3202 N NH1 . ARG B 1 152 ? 111.788 113.834 91.183  1.00 70.94  ? 152 ARG B NH1 1 
ATOM   3203 N NH2 . ARG B 1 152 ? 112.989 112.458 89.803  1.00 70.94  ? 152 ARG B NH2 1 
ATOM   3204 N N   . VAL B 1 153 ? 106.311 114.266 88.525  1.00 77.96  ? 153 VAL B N   1 
ATOM   3205 C CA  . VAL B 1 153 ? 105.621 113.034 88.150  1.00 77.96  ? 153 VAL B CA  1 
ATOM   3206 C C   . VAL B 1 153 ? 104.421 113.357 87.268  1.00 77.96  ? 153 VAL B C   1 
ATOM   3207 O O   . VAL B 1 153 ? 103.912 114.488 87.307  1.00 77.96  ? 153 VAL B O   1 
ATOM   3208 C CB  . VAL B 1 153 ? 105.187 112.250 89.398  1.00 77.96  ? 153 VAL B CB  1 
ATOM   3209 C CG1 . VAL B 1 153 ? 106.395 111.627 90.080  1.00 77.96  ? 153 VAL B CG1 1 
ATOM   3210 C CG2 . VAL B 1 153 ? 104.437 113.160 90.355  1.00 77.96  ? 153 VAL B CG2 1 
ATOM   3211 N N   . PRO B 1 154 ? 103.945 112.411 86.451  1.00 83.56  ? 154 PRO B N   1 
ATOM   3212 C CA  . PRO B 1 154 ? 102.744 112.683 85.643  1.00 83.56  ? 154 PRO B CA  1 
ATOM   3213 C C   . PRO B 1 154 ? 101.542 113.088 86.474  1.00 83.56  ? 154 PRO B C   1 
ATOM   3214 O O   . PRO B 1 154 ? 100.704 113.865 85.997  1.00 83.56  ? 154 PRO B O   1 
ATOM   3215 C CB  . PRO B 1 154 ? 102.507 111.353 84.915  1.00 83.56  ? 154 PRO B CB  1 
ATOM   3216 C CG  . PRO B 1 154 ? 103.852 110.717 84.852  1.00 83.56  ? 154 PRO B CG  1 
ATOM   3217 C CD  . PRO B 1 154 ? 104.557 111.113 86.117  1.00 83.56  ? 154 PRO B CD  1 
ATOM   3218 N N   . ASP B 1 155 ? 101.428 112.589 87.705  1.00 86.14  ? 155 ASP B N   1 
ATOM   3219 C CA  . ASP B 1 155 ? 100.394 113.044 88.632  1.00 86.14  ? 155 ASP B CA  1 
ATOM   3220 C C   . ASP B 1 155 ? 100.817 114.420 89.139  1.00 86.14  ? 155 ASP B C   1 
ATOM   3221 O O   . ASP B 1 155 ? 101.419 114.575 90.205  1.00 86.14  ? 155 ASP B O   1 
ATOM   3222 C CB  . ASP B 1 155 ? 100.204 112.048 89.769  1.00 86.14  ? 155 ASP B CB  1 
ATOM   3223 C CG  . ASP B 1 155 ? 99.000  112.371 90.632  1.00 86.14  ? 155 ASP B CG  1 
ATOM   3224 O OD1 . ASP B 1 155 ? 98.172  113.208 90.214  1.00 86.14  ? 155 ASP B OD1 1 
ATOM   3225 O OD2 . ASP B 1 155 ? 98.881  111.788 91.730  1.00 86.14  ? 155 ASP B OD2 1 
ATOM   3226 N N   . LYS B 1 156 ? 100.502 115.434 88.335  1.00 82.40  ? 156 LYS B N   1 
ATOM   3227 C CA  . LYS B 1 156 ? 100.941 116.795 88.612  1.00 82.40  ? 156 LYS B CA  1 
ATOM   3228 C C   . LYS B 1 156 ? 100.445 117.271 89.970  1.00 82.40  ? 156 LYS B C   1 
ATOM   3229 O O   . LYS B 1 156 ? 99.273  117.098 90.314  1.00 82.40  ? 156 LYS B O   1 
ATOM   3230 C CB  . LYS B 1 156 ? 100.447 117.739 87.516  1.00 82.40  ? 156 LYS B CB  1 
ATOM   3231 C CG  . LYS B 1 156 ? 100.622 119.213 87.849  1.00 82.40  ? 156 LYS B CG  1 
ATOM   3232 C CD  . LYS B 1 156 ? 99.674  120.088 87.046  1.00 82.40  ? 156 LYS B CD  1 
ATOM   3233 C CE  . LYS B 1 156 ? 99.754  121.538 87.495  1.00 82.40  ? 156 LYS B CE  1 
ATOM   3234 N NZ  . LYS B 1 156 ? 98.718  122.382 86.840  1.00 82.40  ? 156 LYS B NZ  1 
ATOM   3235 N N   . ARG B 1 157 ? 101.348 117.875 90.742  1.00 81.81  ? 157 ARG B N   1 
ATOM   3236 C CA  . ARG B 1 157 ? 100.980 118.551 91.984  1.00 81.81  ? 157 ARG B CA  1 
ATOM   3237 C C   . ARG B 1 157 ? 100.282 119.852 91.602  1.00 81.81  ? 157 ARG B C   1 
ATOM   3238 O O   . ARG B 1 157 ? 100.883 120.928 91.548  1.00 81.81  ? 157 ARG B O   1 
ATOM   3239 C CB  . ARG B 1 157 ? 102.204 118.804 92.854  1.00 81.81  ? 157 ARG B CB  1 
ATOM   3240 C CG  . ARG B 1 157 ? 101.887 119.435 94.199  1.00 81.81  ? 157 ARG B CG  1 
ATOM   3241 C CD  . ARG B 1 157 ? 101.302 118.418 95.162  1.00 81.81  ? 157 ARG B CD  1 
ATOM   3242 N NE  . ARG B 1 157 ? 99.848  118.494 95.221  1.00 81.81  ? 157 ARG B NE  1 
ATOM   3243 C CZ  . ARG B 1 157 ? 99.081  117.640 95.885  1.00 81.81  ? 157 ARG B CZ  1 
ATOM   3244 N NH1 . ARG B 1 157 ? 99.598  116.627 96.561  1.00 81.81  ? 157 ARG B NH1 1 
ATOM   3245 N NH2 . ARG B 1 157 ? 97.761  117.806 95.871  1.00 81.81  ? 157 ARG B NH2 1 
ATOM   3246 N N   . VAL B 1 158 ? 98.984  119.735 91.310  1.00 80.43  ? 158 VAL B N   1 
ATOM   3247 C CA  . VAL B 1 158 ? 98.227  120.864 90.772  1.00 80.43  ? 158 VAL B CA  1 
ATOM   3248 C C   . VAL B 1 158 ? 98.287  122.044 91.733  1.00 80.43  ? 158 VAL B C   1 
ATOM   3249 O O   . VAL B 1 158 ? 98.833  123.106 91.410  1.00 80.43  ? 158 VAL B O   1 
ATOM   3250 C CB  . VAL B 1 158 ? 96.775  120.450 90.481  1.00 80.43  ? 158 VAL B CB  1 
ATOM   3251 C CG1 . VAL B 1 158 ? 96.020  121.594 89.820  1.00 80.43  ? 158 VAL B CG1 1 
ATOM   3252 C CG2 . VAL B 1 158 ? 96.743  119.206 89.607  1.00 80.43  ? 158 VAL B CG2 1 
ATOM   3253 N N   . ILE B 1 159 ? 97.747  121.866 92.934  1.00 72.54  ? 159 ILE B N   1 
ATOM   3254 C CA  . ILE B 1 159 ? 97.787  122.899 93.964  1.00 72.54  ? 159 ILE B CA  1 
ATOM   3255 C C   . ILE B 1 159 ? 97.892  122.219 95.319  1.00 72.54  ? 159 ILE B C   1 
ATOM   3256 O O   . ILE B 1 159 ? 97.057  121.381 95.671  1.00 72.54  ? 159 ILE B O   1 
ATOM   3257 C CB  . ILE B 1 159 ? 96.548  123.820 93.922  1.00 72.54  ? 159 ILE B CB  1 
ATOM   3258 C CG1 . ILE B 1 159 ? 96.625  124.797 92.746  1.00 72.54  ? 159 ILE B CG1 1 
ATOM   3259 C CG2 . ILE B 1 159 ? 96.420  124.597 95.220  1.00 72.54  ? 159 ILE B CG2 1 
ATOM   3260 C CD1 . ILE B 1 159 ? 95.360  125.599 92.536  1.00 72.54  ? 159 ILE B CD1 1 
ATOM   3261 N N   . ILE B 1 160 ? 98.923  122.576 96.075  1.00 62.15  ? 160 ILE B N   1 
ATOM   3262 C CA  . ILE B 1 160 ? 99.046  122.204 97.478  1.00 62.15  ? 160 ILE B CA  1 
ATOM   3263 C C   . ILE B 1 160 ? 98.629  123.423 98.297  1.00 62.15  ? 160 ILE B C   1 
ATOM   3264 O O   . ILE B 1 160 ? 99.378  124.392 98.446  1.00 62.15  ? 160 ILE B O   1 
ATOM   3265 C CB  . ILE B 1 160 ? 100.452 121.687 97.808  1.00 62.15  ? 160 ILE B CB  1 
ATOM   3266 C CG1 . ILE B 1 160 ? 100.504 121.085 99.217  1.00 62.15  ? 160 ILE B CG1 1 
ATOM   3267 C CG2 . ILE B 1 160 ? 101.545 122.692 97.458  1.00 62.15  ? 160 ILE B CG2 1 
ATOM   3268 C CD1 . ILE B 1 160 ? 101.750 120.280 99.488  1.00 62.15  ? 160 ILE B CD1 1 
ATOM   3269 N N   . LYS B 1 161 ? 97.402  123.379 98.806  1.00 60.34  ? 161 LYS B N   1 
ATOM   3270 C CA  . LYS B 1 161 ? 96.747  124.566 99.330  1.00 60.34  ? 161 LYS B CA  1 
ATOM   3271 C C   . LYS B 1 161 ? 97.467  125.106 100.561 1.00 60.34  ? 161 LYS B C   1 
ATOM   3272 O O   . LYS B 1 161 ? 98.190  124.394 101.262 1.00 60.34  ? 161 LYS B O   1 
ATOM   3273 C CB  . LYS B 1 161 ? 95.289  124.266 99.681  1.00 60.34  ? 161 LYS B CB  1 
ATOM   3274 C CG  . LYS B 1 161 ? 94.324  124.364 98.510  1.00 60.34  ? 161 LYS B CG  1 
ATOM   3275 C CD  . LYS B 1 161 ? 94.322  123.090 97.683  1.00 60.34  ? 161 LYS B CD  1 
ATOM   3276 C CE  . LYS B 1 161 ? 93.687  121.939 98.445  1.00 60.34  ? 161 LYS B CE  1 
ATOM   3277 N NZ  . LYS B 1 161 ? 93.618  120.700 97.623  1.00 60.34  ? 161 LYS B NZ  1 
ATOM   3278 N N   . ASP B 1 162 ? 97.259  126.400 100.805 1.00 53.70  ? 162 ASP B N   1 
ATOM   3279 C CA  . ASP B 1 162 ? 97.742  127.022 102.032 1.00 53.70  ? 162 ASP B CA  1 
ATOM   3280 C C   . ASP B 1 162 ? 97.087  126.415 103.263 1.00 53.70  ? 162 ASP B C   1 
ATOM   3281 O O   . ASP B 1 162 ? 97.705  126.352 104.338 1.00 53.70  ? 162 ASP B O   1 
ATOM   3282 C CB  . ASP B 1 162 ? 97.476  128.524 101.977 1.00 53.70  ? 162 ASP B CB  1 
ATOM   3283 C CG  . ASP B 1 162 ? 98.549  129.319 102.651 1.00 53.70  ? 162 ASP B CG  1 
ATOM   3284 O OD1 . ASP B 1 162 ? 99.128  128.787 103.614 1.00 53.70  ? 162 ASP B OD1 1 
ATOM   3285 O OD2 . ASP B 1 162 ? 98.816  130.463 102.227 1.00 53.70  ? 162 ASP B OD2 1 
ATOM   3286 N N   . LEU B 1 163 ? 95.851  125.938 103.120 1.00 52.18  ? 163 LEU B N   1 
ATOM   3287 C CA  . LEU B 1 163 ? 95.137  125.381 104.256 1.00 52.18  ? 163 LEU B CA  1 
ATOM   3288 C C   . LEU B 1 163 ? 95.806  124.124 104.783 1.00 52.18  ? 163 LEU B C   1 
ATOM   3289 O O   . LEU B 1 163 ? 95.688  123.831 105.974 1.00 52.18  ? 163 LEU B O   1 
ATOM   3290 C CB  . LEU B 1 163 ? 93.688  125.082 103.870 1.00 52.18  ? 163 LEU B CB  1 
ATOM   3291 C CG  . LEU B 1 163 ? 92.761  126.282 103.660 1.00 52.18  ? 163 LEU B CG  1 
ATOM   3292 C CD1 . LEU B 1 163 ? 92.891  126.837 102.251 1.00 52.18  ? 163 LEU B CD1 1 
ATOM   3293 C CD2 . LEU B 1 163 ? 91.320  125.897 103.958 1.00 52.18  ? 163 LEU B CD2 1 
ATOM   3294 N N   . GLN B 1 164 ? 96.565  123.413 103.949 1.00 53.30  ? 164 GLN B N   1 
ATOM   3295 C CA  . GLN B 1 164 ? 97.267  122.234 104.441 1.00 53.30  ? 164 GLN B CA  1 
ATOM   3296 C C   . GLN B 1 164 ? 98.438  122.625 105.333 1.00 53.30  ? 164 GLN B C   1 
ATOM   3297 O O   . GLN B 1 164 ? 98.648  122.019 106.389 1.00 53.30  ? 164 GLN B O   1 
ATOM   3298 C CB  . GLN B 1 164 ? 97.744  121.377 103.270 1.00 53.30  ? 164 GLN B CB  1 
ATOM   3299 C CG  . GLN B 1 164 ? 96.666  120.487 102.680 1.00 53.30  ? 164 GLN B CG  1 
ATOM   3300 C CD  . GLN B 1 164 ? 97.205  119.545 101.623 1.00 53.30  ? 164 GLN B CD  1 
ATOM   3301 O OE1 . GLN B 1 164 ? 98.386  119.591 101.278 1.00 53.30  ? 164 GLN B OE1 1 
ATOM   3302 N NE2 . GLN B 1 164 ? 96.340  118.683 101.101 1.00 53.30  ? 164 GLN B NE2 1 
ATOM   3303 N N   . LEU B 1 165 ? 99.212  123.634 104.927 1.00 47.91  ? 165 LEU B N   1 
ATOM   3304 C CA  . LEU B 1 165 ? 100.291 124.113 105.783 1.00 47.91  ? 165 LEU B CA  1 
ATOM   3305 C C   . LEU B 1 165 ? 99.743  124.661 107.092 1.00 47.91  ? 165 LEU B C   1 
ATOM   3306 O O   . LEU B 1 165 ? 100.317 124.423 108.165 1.00 47.91  ? 165 LEU B O   1 
ATOM   3307 C CB  . LEU B 1 165 ? 101.117 125.169 105.059 1.00 47.91  ? 165 LEU B CB  1 
ATOM   3308 C CG  . LEU B 1 165 ? 101.737 124.674 103.758 1.00 47.91  ? 165 LEU B CG  1 
ATOM   3309 C CD1 . LEU B 1 165 ? 102.393 125.826 103.036 1.00 47.91  ? 165 LEU B CD1 1 
ATOM   3310 C CD2 . LEU B 1 165 ? 102.727 123.553 104.022 1.00 47.91  ? 165 LEU B CD2 1 
ATOM   3311 N N   . LEU B 1 166 ? 98.630  125.397 107.027 1.00 46.45  ? 166 LEU B N   1 
ATOM   3312 C CA  . LEU B 1 166 ? 97.993  125.822 108.268 1.00 46.45  ? 166 LEU B CA  1 
ATOM   3313 C C   . LEU B 1 166 ? 97.536  124.628 109.093 1.00 46.45  ? 166 LEU B C   1 
ATOM   3314 O O   . LEU B 1 166 ? 97.588  124.675 110.325 1.00 46.45  ? 166 LEU B O   1 
ATOM   3315 C CB  . LEU B 1 166 ? 96.817  126.759 107.985 1.00 46.45  ? 166 LEU B CB  1 
ATOM   3316 C CG  . LEU B 1 166 ? 97.109  128.246 107.759 1.00 46.45  ? 166 LEU B CG  1 
ATOM   3317 C CD1 . LEU B 1 166 ? 97.692  128.852 109.028 1.00 46.45  ? 166 LEU B CD1 1 
ATOM   3318 C CD2 . LEU B 1 166 ? 98.029  128.505 106.583 1.00 46.45  ? 166 LEU B CD2 1 
ATOM   3319 N N   . GLY B 1 167 ? 97.107  123.549 108.440 1.00 44.82  ? 167 GLY B N   1 
ATOM   3320 C CA  . GLY B 1 167 ? 96.729  122.355 109.177 1.00 44.82  ? 167 GLY B CA  1 
ATOM   3321 C C   . GLY B 1 167 ? 97.895  121.741 109.926 1.00 44.82  ? 167 GLY B C   1 
ATOM   3322 O O   . GLY B 1 167 ? 97.766  121.352 111.087 1.00 44.82  ? 167 GLY B O   1 
ATOM   3323 N N   . LEU B 1 168 ? 99.046  121.626 109.260 1.00 45.06  ? 168 LEU B N   1 
ATOM   3324 C CA  . LEU B 1 168 ? 100.230 121.098 109.938 1.00 45.06  ? 168 LEU B CA  1 
ATOM   3325 C C   . LEU B 1 168 ? 100.662 121.991 111.096 1.00 45.06  ? 168 LEU B C   1 
ATOM   3326 O O   . LEU B 1 168 ? 101.007 121.494 112.179 1.00 45.06  ? 168 LEU B O   1 
ATOM   3327 C CB  . LEU B 1 168 ? 101.387 120.899 108.954 1.00 45.06  ? 168 LEU B CB  1 
ATOM   3328 C CG  . LEU B 1 168 ? 101.433 119.686 108.012 1.00 45.06  ? 168 LEU B CG  1 
ATOM   3329 C CD1 . LEU B 1 168 ? 100.426 119.714 106.888 1.00 45.06  ? 168 LEU B CD1 1 
ATOM   3330 C CD2 . LEU B 1 168 ? 102.843 119.538 107.448 1.00 45.06  ? 168 LEU B CD2 1 
ATOM   3331 N N   . VAL B 1 169 ? 100.650 123.311 110.894 1.00 42.10  ? 169 VAL B N   1 
ATOM   3332 C CA  . VAL B 1 169 ? 101.033 124.217 111.975 1.00 42.10  ? 169 VAL B CA  1 
ATOM   3333 C C   . VAL B 1 169 ? 100.061 124.094 113.143 1.00 42.10  ? 169 VAL B C   1 
ATOM   3334 O O   . VAL B 1 169 ? 100.466 124.086 114.313 1.00 42.10  ? 169 VAL B O   1 
ATOM   3335 C CB  . VAL B 1 169 ? 101.122 125.664 111.459 1.00 42.10  ? 169 VAL B CB  1 
ATOM   3336 C CG1 . VAL B 1 169 ? 101.352 126.617 112.612 1.00 42.10  ? 169 VAL B CG1 1 
ATOM   3337 C CG2 . VAL B 1 169 ? 102.234 125.790 110.431 1.00 42.10  ? 169 VAL B CG2 1 
ATOM   3338 N N   . ALA B 1 170 ? 98.764  123.985 112.844 1.00 41.79  ? 170 ALA B N   1 
ATOM   3339 C CA  . ALA B 1 170 ? 97.760  123.823 113.888 1.00 41.79  ? 170 ALA B CA  1 
ATOM   3340 C C   . ALA B 1 170 ? 97.938  122.508 114.630 1.00 41.79  ? 170 ALA B C   1 
ATOM   3341 O O   . ALA B 1 170 ? 97.757  122.450 115.849 1.00 41.79  ? 170 ALA B O   1 
ATOM   3342 C CB  . ALA B 1 170 ? 96.361  123.913 113.283 1.00 41.79  ? 170 ALA B CB  1 
ATOM   3343 N N   . ALA B 1 171 ? 98.271  121.435 113.912 1.00 41.76  ? 171 ALA B N   1 
ATOM   3344 C CA  . ALA B 1 171 ? 98.499  120.150 114.564 1.00 41.76  ? 171 ALA B CA  1 
ATOM   3345 C C   . ALA B 1 171 ? 99.694  120.218 115.504 1.00 41.76  ? 171 ALA B C   1 
ATOM   3346 O O   . ALA B 1 171 ? 99.649  119.687 116.621 1.00 41.76  ? 171 ALA B O   1 
ATOM   3347 C CB  . ALA B 1 171 ? 98.701  119.056 113.517 1.00 41.76  ? 171 ALA B CB  1 
ATOM   3348 N N   . LEU B 1 172 ? 100.774 120.867 115.069 1.00 41.44  ? 172 LEU B N   1 
ATOM   3349 C CA  . LEU B 1 172 ? 101.939 121.003 115.938 1.00 41.44  ? 172 LEU B CA  1 
ATOM   3350 C C   . LEU B 1 172 ? 101.612 121.857 117.159 1.00 41.44  ? 172 LEU B C   1 
ATOM   3351 O O   . LEU B 1 172 ? 102.046 121.549 118.279 1.00 41.44  ? 172 LEU B O   1 
ATOM   3352 C CB  . LEU B 1 172 ? 103.107 121.590 115.149 1.00 41.44  ? 172 LEU B CB  1 
ATOM   3353 C CG  . LEU B 1 172 ? 104.488 121.662 115.798 1.00 41.44  ? 172 LEU B CG  1 
ATOM   3354 C CD1 . LEU B 1 172 ? 105.525 121.627 114.704 1.00 41.44  ? 172 LEU B CD1 1 
ATOM   3355 C CD2 . LEU B 1 172 ? 104.663 122.914 116.629 1.00 41.44  ? 172 LEU B CD2 1 
ATOM   3356 N N   . LEU B 1 173 ? 100.846 122.933 116.963 1.00 42.62  ? 173 LEU B N   1 
ATOM   3357 C CA  . LEU B 1 173 ? 100.411 123.745 118.094 1.00 42.62  ? 173 LEU B CA  1 
ATOM   3358 C C   . LEU B 1 173 ? 99.561  122.931 119.056 1.00 42.62  ? 173 LEU B C   1 
ATOM   3359 O O   . LEU B 1 173 ? 99.706  123.054 120.274 1.00 42.62  ? 173 LEU B O   1 
ATOM   3360 C CB  . LEU B 1 173 ? 99.631  124.962 117.606 1.00 42.62  ? 173 LEU B CB  1 
ATOM   3361 C CG  . LEU B 1 173 ? 100.423 126.226 117.291 1.00 42.62  ? 173 LEU B CG  1 
ATOM   3362 C CD1 . LEU B 1 173 ? 99.500  127.253 116.670 1.00 42.62  ? 173 LEU B CD1 1 
ATOM   3363 C CD2 . LEU B 1 173 ? 101.078 126.773 118.545 1.00 42.62  ? 173 LEU B CD2 1 
ATOM   3364 N N   . MET B 1 174 ? 98.666  122.096 118.528 1.00 44.73  ? 174 MET B N   1 
ATOM   3365 C CA  . MET B 1 174 ? 97.839  121.251 119.381 1.00 44.73  ? 174 MET B CA  1 
ATOM   3366 C C   . MET B 1 174 ? 98.691  120.273 120.176 1.00 44.73  ? 174 MET B C   1 
ATOM   3367 O O   . MET B 1 174 ? 98.414  120.010 121.351 1.00 44.73  ? 174 MET B O   1 
ATOM   3368 C CB  . MET B 1 174 ? 96.809  120.503 118.535 1.00 44.73  ? 174 MET B CB  1 
ATOM   3369 C CG  . MET B 1 174 ? 95.816  119.684 119.344 1.00 44.73  ? 174 MET B CG  1 
ATOM   3370 S SD  . MET B 1 174 ? 94.781  120.703 120.411 1.00 44.73  ? 174 MET B SD  1 
ATOM   3371 C CE  . MET B 1 174 ? 93.710  121.477 119.202 1.00 44.73  ? 174 MET B CE  1 
ATOM   3372 N N   . ALA B 1 175 ? 99.732  119.719 119.552 1.00 42.64  ? 175 ALA B N   1 
ATOM   3373 C CA  . ALA B 1 175 ? 100.640 118.837 120.280 1.00 42.64  ? 175 ALA B CA  1 
ATOM   3374 C C   . ALA B 1 175 ? 101.335 119.587 121.410 1.00 42.64  ? 175 ALA B C   1 
ATOM   3375 O O   . ALA B 1 175 ? 101.467 119.070 122.531 1.00 42.64  ? 175 ALA B O   1 
ATOM   3376 C CB  . ALA B 1 175 ? 101.668 118.233 119.325 1.00 42.64  ? 175 ALA B CB  1 
ATOM   3377 N N   . ASP B 1 176 ? 101.772 120.816 121.136 1.00 43.43  ? 176 ASP B N   1 
ATOM   3378 C CA  . ASP B 1 176 ? 102.394 121.622 122.179 1.00 43.43  ? 176 ASP B CA  1 
ATOM   3379 C C   . ASP B 1 176 ? 101.414 121.927 123.306 1.00 43.43  ? 176 ASP B C   1 
ATOM   3380 O O   . ASP B 1 176 ? 101.794 121.926 124.481 1.00 43.43  ? 176 ASP B O   1 
ATOM   3381 C CB  . ASP B 1 176 ? 102.952 122.911 121.582 1.00 43.43  ? 176 ASP B CB  1 
ATOM   3382 C CG  . ASP B 1 176 ? 104.374 122.748 121.082 1.00 43.43  ? 176 ASP B CG  1 
ATOM   3383 O OD1 . ASP B 1 176 ? 105.227 122.265 121.856 1.00 43.43  ? 176 ASP B OD1 1 
ATOM   3384 O OD2 . ASP B 1 176 ? 104.637 123.094 119.912 1.00 43.43  ? 176 ASP B OD2 1 
ATOM   3385 N N   . VAL B 1 177 ? 100.149 122.197 122.971 1.00 42.64  ? 177 VAL B N   1 
ATOM   3386 C CA  . VAL B 1 177 ? 99.155  122.461 124.010 1.00 42.64  ? 177 VAL B CA  1 
ATOM   3387 C C   . VAL B 1 177 ? 98.887  121.209 124.834 1.00 42.64  ? 177 VAL B C   1 
ATOM   3388 O O   . VAL B 1 177 ? 98.659  121.292 126.043 1.00 42.64  ? 177 VAL B O   1 
ATOM   3389 C CB  . VAL B 1 177 ? 97.857  123.036 123.418 1.00 42.64  ? 177 VAL B CB  1 
ATOM   3390 C CG1 . VAL B 1 177 ? 96.959  123.531 124.534 1.00 42.64  ? 177 VAL B CG1 1 
ATOM   3391 C CG2 . VAL B 1 177 ? 98.164  124.208 122.522 1.00 42.64  ? 177 VAL B CG2 1 
ATOM   3392 N N   . ILE B 1 178 ? 98.890  120.035 124.203 1.00 42.03  ? 178 ILE B N   1 
ATOM   3393 C CA  . ILE B 1 178 ? 98.719  118.801 124.968 1.00 42.03  ? 178 ILE B CA  1 
ATOM   3394 C C   . ILE B 1 178 ? 99.870  118.623 125.949 1.00 42.03  ? 178 ILE B C   1 
ATOM   3395 O O   . ILE B 1 178 ? 99.663  118.275 127.119 1.00 42.03  ? 178 ILE B O   1 
ATOM   3396 C CB  . ILE B 1 178 ? 98.579  117.589 124.031 1.00 42.03  ? 178 ILE B CB  1 
ATOM   3397 C CG1 . ILE B 1 178 ? 97.322  117.718 123.171 1.00 42.03  ? 178 ILE B CG1 1 
ATOM   3398 C CG2 . ILE B 1 178 ? 98.541  116.304 124.832 1.00 42.03  ? 178 ILE B CG2 1 
ATOM   3399 C CD1 . ILE B 1 178 ? 97.243  116.709 122.049 1.00 42.03  ? 178 ILE B CD1 1 
ATOM   3400 N N   . LEU B 1 179 ? 101.099 118.873 125.493 1.00 41.78  ? 179 LEU B N   1 
ATOM   3401 C CA  . LEU B 1 179 ? 102.249 118.767 126.389 1.00 41.78  ? 179 LEU B CA  1 
ATOM   3402 C C   . LEU B 1 179 ? 102.162 119.776 127.529 1.00 41.78  ? 179 LEU B C   1 
ATOM   3403 O O   . LEU B 1 179 ? 102.442 119.445 128.688 1.00 41.78  ? 179 LEU B O   1 
ATOM   3404 C CB  . LEU B 1 179 ? 103.547 118.954 125.607 1.00 41.78  ? 179 LEU B CB  1 
ATOM   3405 C CG  . LEU B 1 179 ? 103.897 117.852 124.604 1.00 41.78  ? 179 LEU B CG  1 
ATOM   3406 C CD1 . LEU B 1 179 ? 105.218 118.151 123.912 1.00 41.78  ? 179 LEU B CD1 1 
ATOM   3407 C CD2 . LEU B 1 179 ? 103.942 116.498 125.289 1.00 41.78  ? 179 LEU B CD2 1 
ATOM   3408 N N   . LEU B 1 180 ? 101.769 121.012 127.220 1.00 40.89  ? 180 LEU B N   1 
ATOM   3409 C CA  . LEU B 1 180 ? 101.658 122.039 128.250 1.00 40.89  ? 180 LEU B CA  1 
ATOM   3410 C C   . LEU B 1 180 ? 100.564 121.710 129.258 1.00 40.89  ? 180 LEU B C   1 
ATOM   3411 O O   . LEU B 1 180 ? 100.742 121.920 130.462 1.00 40.89  ? 180 LEU B O   1 
ATOM   3412 C CB  . LEU B 1 180 ? 101.402 123.397 127.601 1.00 40.89  ? 180 LEU B CB  1 
ATOM   3413 C CG  . LEU B 1 180 ? 102.617 124.289 127.340 1.00 40.89  ? 180 LEU B CG  1 
ATOM   3414 C CD1 . LEU B 1 180 ? 103.197 124.798 128.644 1.00 40.89  ? 180 LEU B CD1 1 
ATOM   3415 C CD2 . LEU B 1 180 ? 103.676 123.553 126.544 1.00 40.89  ? 180 LEU B CD2 1 
ATOM   3416 N N   . MET B 1 181 ? 99.422  121.204 128.787 1.00 42.95  ? 181 MET B N   1 
ATOM   3417 C CA  . MET B 1 181 ? 98.350  120.823 129.699 1.00 42.95  ? 181 MET B CA  1 
ATOM   3418 C C   . MET B 1 181 ? 98.780  119.672 130.593 1.00 42.95  ? 181 MET B C   1 
ATOM   3419 O O   . MET B 1 181 ? 98.475  119.661 131.791 1.00 42.95  ? 181 MET B O   1 
ATOM   3420 C CB  . MET B 1 181 ? 97.093  120.453 128.915 1.00 42.95  ? 181 MET B CB  1 
ATOM   3421 C CG  . MET B 1 181 ? 96.350  121.642 128.338 1.00 42.95  ? 181 MET B CG  1 
ATOM   3422 S SD  . MET B 1 181 ? 95.429  121.220 126.846 1.00 42.95  ? 181 MET B SD  1 
ATOM   3423 C CE  . MET B 1 181 ? 94.848  119.577 127.257 1.00 42.95  ? 181 MET B CE  1 
ATOM   3424 N N   . THR B 1 182 ? 99.492  118.692 130.030 1.00 41.43  ? 182 THR B N   1 
ATOM   3425 C CA  . THR B 1 182 ? 100.005 117.596 130.846 1.00 41.43  ? 182 THR B CA  1 
ATOM   3426 C C   . THR B 1 182 ? 100.967 118.109 131.909 1.00 41.43  ? 182 THR B C   1 
ATOM   3427 O O   . THR B 1 182 ? 100.904 117.686 133.069 1.00 41.43  ? 182 THR B O   1 
ATOM   3428 C CB  . THR B 1 182 ? 100.688 116.556 129.961 1.00 41.43  ? 182 THR B CB  1 
ATOM   3429 O OG1 . THR B 1 182 ? 99.752  116.054 129.001 1.00 41.43  ? 182 THR B OG1 1 
ATOM   3430 C CG2 . THR B 1 182 ? 101.212 115.405 130.800 1.00 41.43  ? 182 THR B CG2 1 
ATOM   3431 N N   . TRP B 1 183 ? 101.858 119.032 131.534 1.00 41.68  ? 183 TRP B N   1 
ATOM   3432 C CA  . TRP B 1 183 ? 102.790 119.593 132.508 1.00 41.68  ? 183 TRP B CA  1 
ATOM   3433 C C   . TRP B 1 183 ? 102.060 120.349 133.609 1.00 41.68  ? 183 TRP B C   1 
ATOM   3434 O O   . TRP B 1 183 ? 102.369 120.185 134.794 1.00 41.68  ? 183 TRP B O   1 
ATOM   3435 C CB  . TRP B 1 183 ? 103.790 120.514 131.809 1.00 41.68  ? 183 TRP B CB  1 
ATOM   3436 C CG  . TRP B 1 183 ? 104.585 121.362 132.756 1.00 41.68  ? 183 TRP B CG  1 
ATOM   3437 C CD1 . TRP B 1 183 ? 105.164 120.964 133.923 1.00 41.68  ? 183 TRP B CD1 1 
ATOM   3438 C CD2 . TRP B 1 183 ? 104.887 122.754 132.616 1.00 41.68  ? 183 TRP B CD2 1 
ATOM   3439 N NE1 . TRP B 1 183 ? 105.803 122.020 134.520 1.00 41.68  ? 183 TRP B NE1 1 
ATOM   3440 C CE2 . TRP B 1 183 ? 105.645 123.131 133.736 1.00 41.68  ? 183 TRP B CE2 1 
ATOM   3441 C CE3 . TRP B 1 183 ? 104.583 123.718 131.655 1.00 41.68  ? 183 TRP B CE3 1 
ATOM   3442 C CZ2 . TRP B 1 183 ? 106.108 124.428 133.918 1.00 41.68  ? 183 TRP B CZ2 1 
ATOM   3443 C CZ3 . TRP B 1 183 ? 105.043 125.005 131.840 1.00 41.68  ? 183 TRP B CZ3 1 
ATOM   3444 C CH2 . TRP B 1 183 ? 105.796 125.348 132.962 1.00 41.68  ? 183 TRP B CH2 1 
ATOM   3445 N N   . VAL B 1 184 ? 101.083 121.177 133.239 1.00 42.48  ? 184 VAL B N   1 
ATOM   3446 C CA  . VAL B 1 184 ? 100.392 121.997 134.228 1.00 42.48  ? 184 VAL B CA  1 
ATOM   3447 C C   . VAL B 1 184 ? 99.561  121.133 135.171 1.00 42.48  ? 184 VAL B C   1 
ATOM   3448 O O   . VAL B 1 184 ? 99.573  121.337 136.391 1.00 42.48  ? 184 VAL B O   1 
ATOM   3449 C CB  . VAL B 1 184 ? 99.536  123.067 133.531 1.00 42.48  ? 184 VAL B CB  1 
ATOM   3450 C CG1 . VAL B 1 184 ? 98.633  123.758 134.536 1.00 42.48  ? 184 VAL B CG1 1 
ATOM   3451 C CG2 . VAL B 1 184 ? 100.429 124.078 132.842 1.00 42.48  ? 184 VAL B CG2 1 
ATOM   3452 N N   . LEU B 1 185 ? 98.827  120.161 134.632 1.00 43.94  ? 185 LEU B N   1 
ATOM   3453 C CA  . LEU B 1 185 ? 97.889  119.379 135.425 1.00 43.94  ? 185 LEU B CA  1 
ATOM   3454 C C   . LEU B 1 185 ? 98.491  118.100 135.991 1.00 43.94  ? 185 LEU B C   1 
ATOM   3455 O O   . LEU B 1 185 ? 97.779  117.347 136.663 1.00 43.94  ? 185 LEU B O   1 
ATOM   3456 C CB  . LEU B 1 185 ? 96.658  119.037 134.583 1.00 43.94  ? 185 LEU B CB  1 
ATOM   3457 C CG  . LEU B 1 185 ? 95.945  120.222 133.936 1.00 43.94  ? 185 LEU B CG  1 
ATOM   3458 C CD1 . LEU B 1 185 ? 94.945  119.752 132.896 1.00 43.94  ? 185 LEU B CD1 1 
ATOM   3459 C CD2 . LEU B 1 185 ? 95.260  121.076 134.992 1.00 43.94  ? 185 LEU B CD2 1 
ATOM   3460 N N   . THR B 1 186 ? 99.771  117.830 135.743 1.00 45.70  ? 186 THR B N   1 
ATOM   3461 C CA  . THR B 1 186 ? 100.440 116.663 136.300 1.00 45.70  ? 186 THR B CA  1 
ATOM   3462 C C   . THR B 1 186 ? 101.486 117.031 137.340 1.00 45.70  ? 186 THR B C   1 
ATOM   3463 O O   . THR B 1 186 ? 101.462 116.505 138.457 1.00 45.70  ? 186 THR B O   1 
ATOM   3464 C CB  . THR B 1 186 ? 101.091 115.845 135.179 1.00 45.70  ? 186 THR B CB  1 
ATOM   3465 O OG1 . THR B 1 186 ? 100.124 115.582 134.156 1.00 45.70  ? 186 THR B OG1 1 
ATOM   3466 C CG2 . THR B 1 186 ? 101.617 114.527 135.721 1.00 45.70  ? 186 THR B CG2 1 
ATOM   3467 N N   . ASP B 1 187 ? 102.412 117.924 136.997 1.00 47.69  ? 187 ASP B N   1 
ATOM   3468 C CA  . ASP B 1 187 ? 103.418 118.417 137.935 1.00 47.69  ? 187 ASP B CA  1 
ATOM   3469 C C   . ASP B 1 187 ? 103.615 119.902 137.676 1.00 47.69  ? 187 ASP B C   1 
ATOM   3470 O O   . ASP B 1 187 ? 104.479 120.302 136.885 1.00 47.69  ? 187 ASP B O   1 
ATOM   3471 C CB  . ASP B 1 187 ? 104.736 117.655 137.795 1.00 47.69  ? 187 ASP B CB  1 
ATOM   3472 C CG  . ASP B 1 187 ? 105.744 118.044 138.850 1.00 47.69  ? 187 ASP B CG  1 
ATOM   3473 O OD1 . ASP B 1 187 ? 105.330 118.560 139.908 1.00 47.69  ? 187 ASP B OD1 1 
ATOM   3474 O OD2 . ASP B 1 187 ? 106.954 117.836 138.622 1.00 47.69  ? 187 ASP B OD2 1 
ATOM   3475 N N   . PRO B 1 188 ? 102.831 120.751 138.326 1.00 48.80  ? 188 PRO B N   1 
ATOM   3476 C CA  . PRO B 1 188 ? 102.892 122.188 138.060 1.00 48.80  ? 188 PRO B CA  1 
ATOM   3477 C C   . PRO B 1 188 ? 104.062 122.828 138.798 1.00 48.80  ? 188 PRO B C   1 
ATOM   3478 O O   . PRO B 1 188 ? 104.848 122.164 139.470 1.00 48.80  ? 188 PRO B O   1 
ATOM   3479 C CB  . PRO B 1 188 ? 101.550 122.690 138.589 1.00 48.80  ? 188 PRO B CB  1 
ATOM   3480 C CG  . PRO B 1 188 ? 101.231 121.761 139.708 1.00 48.80  ? 188 PRO B CG  1 
ATOM   3481 C CD  . PRO B 1 188 ? 101.853 120.424 139.376 1.00 48.80  ? 188 PRO B CD  1 
ATOM   3482 N N   . ILE B 1 189 ? 104.163 124.146 138.660 1.00 51.41  ? 189 ILE B N   1 
ATOM   3483 C CA  . ILE B 1 189 ? 105.219 124.915 139.307 1.00 51.41  ? 189 ILE B CA  1 
ATOM   3484 C C   . ILE B 1 189 ? 104.694 125.400 140.649 1.00 51.41  ? 189 ILE B C   1 
ATOM   3485 O O   . ILE B 1 189 ? 103.829 126.277 140.710 1.00 51.41  ? 189 ILE B O   1 
ATOM   3486 C CB  . ILE B 1 189 ? 105.678 126.087 138.437 1.00 51.41  ? 189 ILE B CB  1 
ATOM   3487 C CG1 . ILE B 1 189 ? 106.401 125.569 137.198 1.00 51.41  ? 189 ILE B CG1 1 
ATOM   3488 C CG2 . ILE B 1 189 ? 106.581 127.009 139.230 1.00 51.41  ? 189 ILE B CG2 1 
ATOM   3489 C CD1 . ILE B 1 189 ? 107.049 126.652 136.382 1.00 51.41  ? 189 ILE B CD1 1 
ATOM   3490 N N   . GLN B 1 190 ? 105.206 124.820 141.728 1.00 61.67  ? 190 GLN B N   1 
ATOM   3491 C CA  . GLN B 1 190 ? 104.902 125.267 143.078 1.00 61.67  ? 190 GLN B CA  1 
ATOM   3492 C C   . GLN B 1 190 ? 106.111 126.005 143.634 1.00 61.67  ? 190 GLN B C   1 
ATOM   3493 O O   . GLN B 1 190 ? 107.239 125.508 143.552 1.00 61.67  ? 190 GLN B O   1 
ATOM   3494 C CB  . GLN B 1 190 ? 104.505 124.090 143.976 1.00 61.67  ? 190 GLN B CB  1 
ATOM   3495 C CG  . GLN B 1 190 ? 105.567 123.024 144.150 1.00 61.67  ? 190 GLN B CG  1 
ATOM   3496 C CD  . GLN B 1 190 ? 104.978 121.638 144.279 1.00 61.67  ? 190 GLN B CD  1 
ATOM   3497 O OE1 . GLN B 1 190 ? 104.351 121.309 145.285 1.00 61.67  ? 190 GLN B OE1 1 
ATOM   3498 N NE2 . GLN B 1 190 ? 105.175 120.813 143.257 1.00 61.67  ? 190 GLN B NE2 1 
ATOM   3499 N N   . CYS B 1 191 ? 105.879 127.197 144.174 1.00 71.03  ? 191 CYS B N   1 
ATOM   3500 C CA  . CYS B 1 191 ? 106.950 127.998 144.747 1.00 71.03  ? 191 CYS B CA  1 
ATOM   3501 C C   . CYS B 1 191 ? 107.172 127.547 146.182 1.00 71.03  ? 191 CYS B C   1 
ATOM   3502 O O   . CYS B 1 191 ? 106.246 127.577 146.999 1.00 71.03  ? 191 CYS B O   1 
ATOM   3503 C CB  . CYS B 1 191 ? 106.604 129.485 144.696 1.00 71.03  ? 191 CYS B CB  1 
ATOM   3504 S SG  . CYS B 1 191 ? 106.772 130.248 143.067 1.00 71.03  ? 191 CYS B SG  1 
ATOM   3505 N N   . LEU B 1 192 ? 108.396 127.135 146.487 1.00 79.47  ? 192 LEU B N   1 
ATOM   3506 C CA  . LEU B 1 192 ? 108.737 126.639 147.809 1.00 79.47  ? 192 LEU B CA  1 
ATOM   3507 C C   . LEU B 1 192 ? 110.015 127.300 148.295 1.00 79.47  ? 192 LEU B C   1 
ATOM   3508 O O   . LEU B 1 192 ? 110.953 127.502 147.520 1.00 79.47  ? 192 LEU B O   1 
ATOM   3509 C CB  . LEU B 1 192 ? 108.911 125.118 147.782 1.00 79.47  ? 192 LEU B CB  1 
ATOM   3510 C CG  . LEU B 1 192 ? 107.675 124.321 147.359 1.00 79.47  ? 192 LEU B CG  1 
ATOM   3511 C CD1 . LEU B 1 192 ? 108.018 122.857 147.134 1.00 79.47  ? 192 LEU B CD1 1 
ATOM   3512 C CD2 . LEU B 1 192 ? 106.577 124.463 148.396 1.00 79.47  ? 192 LEU B CD2 1 
ATOM   3513 N N   . GLN B 1 193 ? 110.045 127.634 149.581 1.00 94.68  ? 193 GLN B N   1 
ATOM   3514 C CA  . GLN B 1 193 ? 111.259 128.071 150.255 1.00 94.68  ? 193 GLN B CA  1 
ATOM   3515 C C   . GLN B 1 193 ? 111.753 126.939 151.143 1.00 94.68  ? 193 GLN B C   1 
ATOM   3516 O O   . GLN B 1 193 ? 110.997 126.423 151.972 1.00 94.68  ? 193 GLN B O   1 
ATOM   3517 C CB  . GLN B 1 193 ? 111.012 129.335 151.080 1.00 94.68  ? 193 GLN B CB  1 
ATOM   3518 C CG  . GLN B 1 193 ? 112.249 129.859 151.790 1.00 94.68  ? 193 GLN B CG  1 
ATOM   3519 C CD  . GLN B 1 193 ? 111.953 131.062 152.665 1.00 94.68  ? 193 GLN B CD  1 
ATOM   3520 O OE1 . GLN B 1 193 ? 110.837 131.581 152.669 1.00 94.68  ? 193 GLN B OE1 1 
ATOM   3521 N NE2 . GLN B 1 193 ? 112.955 131.512 153.411 1.00 94.68  ? 193 GLN B NE2 1 
ATOM   3522 N N   . ILE B 1 194 ? 113.013 126.554 150.969 1.00 95.30  ? 194 ILE B N   1 
ATOM   3523 C CA  . ILE B 1 194 ? 113.587 125.403 151.656 1.00 95.30  ? 194 ILE B CA  1 
ATOM   3524 C C   . ILE B 1 194 ? 114.885 125.833 152.325 1.00 95.30  ? 194 ILE B C   1 
ATOM   3525 O O   . ILE B 1 194 ? 115.789 126.361 151.666 1.00 95.30  ? 194 ILE B O   1 
ATOM   3526 C CB  . ILE B 1 194 ? 113.809 124.202 150.715 1.00 95.30  ? 194 ILE B CB  1 
ATOM   3527 C CG1 . ILE B 1 194 ? 114.797 124.524 149.592 1.00 95.30  ? 194 ILE B CG1 1 
ATOM   3528 C CG2 . ILE B 1 194 ? 112.485 123.721 150.139 1.00 95.30  ? 194 ILE B CG2 1 
ATOM   3529 C CD1 . ILE B 1 194 ? 115.216 123.311 148.796 1.00 95.30  ? 194 ILE B CD1 1 
ATOM   3530 N N   . LEU B 1 195 ? 114.960 125.649 153.639 1.00 101.45 ? 195 LEU B N   1 
ATOM   3531 C CA  . LEU B 1 195 ? 116.204 125.792 154.379 1.00 101.45 ? 195 LEU B CA  1 
ATOM   3532 C C   . LEU B 1 195 ? 116.500 124.465 155.059 1.00 101.45 ? 195 LEU B C   1 
ATOM   3533 O O   . LEU B 1 195 ? 115.610 123.857 155.662 1.00 101.45 ? 195 LEU B O   1 
ATOM   3534 C CB  . LEU B 1 195 ? 116.120 126.944 155.391 1.00 101.45 ? 195 LEU B CB  1 
ATOM   3535 C CG  . LEU B 1 195 ? 115.105 126.952 156.541 1.00 101.45 ? 195 LEU B CG  1 
ATOM   3536 C CD1 . LEU B 1 195 ? 115.597 126.188 157.768 1.00 101.45 ? 195 LEU B CD1 1 
ATOM   3537 C CD2 . LEU B 1 195 ? 114.737 128.382 156.912 1.00 101.45 ? 195 LEU B CD2 1 
ATOM   3538 N N   . SER B 1 196 ? 117.740 124.007 154.932 1.00 106.38 ? 196 SER B N   1 
ATOM   3539 C CA  . SER B 1 196 ? 118.092 122.667 155.371 1.00 106.38 ? 196 SER B CA  1 
ATOM   3540 C C   . SER B 1 196 ? 119.576 122.617 155.689 1.00 106.38 ? 196 SER B C   1 
ATOM   3541 O O   . SER B 1 196 ? 120.353 123.477 155.266 1.00 106.38 ? 196 SER B O   1 
ATOM   3542 C CB  . SER B 1 196 ? 117.737 121.623 154.308 1.00 106.38 ? 196 SER B CB  1 
ATOM   3543 O OG  . SER B 1 196 ? 118.577 121.746 153.173 1.00 106.38 ? 196 SER B OG  1 
ATOM   3544 N N   . VAL B 1 197 ? 119.956 121.588 156.440 1.00 110.69 ? 197 VAL B N   1 
ATOM   3545 C CA  . VAL B 1 197 ? 121.345 121.325 156.784 1.00 110.69 ? 197 VAL B CA  1 
ATOM   3546 C C   . VAL B 1 197 ? 121.736 119.982 156.185 1.00 110.69 ? 197 VAL B C   1 
ATOM   3547 O O   . VAL B 1 197 ? 121.029 118.983 156.365 1.00 110.69 ? 197 VAL B O   1 
ATOM   3548 C CB  . VAL B 1 197 ? 121.574 121.354 158.308 1.00 110.69 ? 197 VAL B CB  1 
ATOM   3549 C CG1 . VAL B 1 197 ? 121.376 122.763 158.840 1.00 110.69 ? 197 VAL B CG1 1 
ATOM   3550 C CG2 . VAL B 1 197 ? 120.629 120.397 159.023 1.00 110.69 ? 197 VAL B CG2 1 
ATOM   3551 N N   . SER B 1 198 ? 122.833 119.971 155.434 1.00 111.71 ? 198 SER B N   1 
ATOM   3552 C CA  . SER B 1 198 ? 123.287 118.789 154.717 1.00 111.71 ? 198 SER B CA  1 
ATOM   3553 C C   . SER B 1 198 ? 124.695 118.449 155.176 1.00 111.71 ? 198 SER B C   1 
ATOM   3554 O O   . SER B 1 198 ? 125.563 119.327 155.228 1.00 111.71 ? 198 SER B O   1 
ATOM   3555 C CB  . SER B 1 198 ? 123.259 119.014 153.203 1.00 111.71 ? 198 SER B CB  1 
ATOM   3556 O OG  . SER B 1 198 ? 124.286 119.903 152.799 1.00 111.71 ? 198 SER B OG  1 
ATOM   3557 N N   . MET B 1 199 ? 124.919 117.182 155.510 1.00 111.72 ? 199 MET B N   1 
ATOM   3558 C CA  . MET B 1 199 ? 126.229 116.704 155.933 1.00 111.72 ? 199 MET B CA  1 
ATOM   3559 C C   . MET B 1 199 ? 126.807 115.841 154.819 1.00 111.72 ? 199 MET B C   1 
ATOM   3560 O O   . MET B 1 199 ? 126.298 114.749 154.544 1.00 111.72 ? 199 MET B O   1 
ATOM   3561 C CB  . MET B 1 199 ? 126.125 115.924 157.241 1.00 111.72 ? 199 MET B CB  1 
ATOM   3562 C CG  . MET B 1 199 ? 127.462 115.603 157.882 1.00 111.72 ? 199 MET B CG  1 
ATOM   3563 S SD  . MET B 1 199 ? 127.263 114.807 159.484 1.00 111.72 ? 199 MET B SD  1 
ATOM   3564 C CE  . MET B 1 199 ? 126.593 116.162 160.444 1.00 111.72 ? 199 MET B CE  1 
ATOM   3565 N N   . THR B 1 200 ? 127.866 116.331 154.183 1.00 108.48 ? 200 THR B N   1 
ATOM   3566 C CA  . THR B 1 200 ? 128.490 115.634 153.068 1.00 108.48 ? 200 THR B CA  1 
ATOM   3567 C C   . THR B 1 200 ? 129.639 114.775 153.577 1.00 108.48 ? 200 THR B C   1 
ATOM   3568 O O   . THR B 1 200 ? 130.528 115.268 154.278 1.00 108.48 ? 200 THR B O   1 
ATOM   3569 C CB  . THR B 1 200 ? 128.996 116.629 152.022 1.00 108.48 ? 200 THR B CB  1 
ATOM   3570 O OG1 . THR B 1 200 ? 127.894 117.386 151.506 1.00 108.48 ? 200 THR B OG1 1 
ATOM   3571 C CG2 . THR B 1 200 ? 129.680 115.896 150.876 1.00 108.48 ? 200 THR B CG2 1 
ATOM   3572 N N   . VAL B 1 201 ? 129.618 113.494 153.224 1.00 108.03 ? 201 VAL B N   1 
ATOM   3573 C CA  . VAL B 1 201 ? 130.670 112.552 153.588 1.00 108.03 ? 201 VAL B CA  1 
ATOM   3574 C C   . VAL B 1 201 ? 131.163 111.905 152.302 1.00 108.03 ? 201 VAL B C   1 
ATOM   3575 O O   . VAL B 1 201 ? 130.411 111.178 151.641 1.00 108.03 ? 201 VAL B O   1 
ATOM   3576 C CB  . VAL B 1 201 ? 130.185 111.489 154.583 1.00 108.03 ? 201 VAL B CB  1 
ATOM   3577 C CG1 . VAL B 1 201 ? 131.343 110.603 155.016 1.00 108.03 ? 201 VAL B CG1 1 
ATOM   3578 C CG2 . VAL B 1 201 ? 129.533 112.147 155.790 1.00 108.03 ? 201 VAL B CG2 1 
ATOM   3579 N N   . THR B 1 202 ? 132.417 112.167 151.946 1.00 110.56 ? 202 THR B N   1 
ATOM   3580 C CA  . THR B 1 202 ? 133.024 111.602 150.748 1.00 110.56 ? 202 THR B CA  1 
ATOM   3581 C C   . THR B 1 202 ? 133.771 110.303 151.017 1.00 110.56 ? 202 THR B C   1 
ATOM   3582 O O   . THR B 1 202 ? 134.403 109.767 150.100 1.00 110.56 ? 202 THR B O   1 
ATOM   3583 C CB  . THR B 1 202 ? 133.979 112.616 150.110 1.00 110.56 ? 202 THR B CB  1 
ATOM   3584 O OG1 . THR B 1 202 ? 135.040 112.918 151.024 1.00 110.56 ? 202 THR B OG1 1 
ATOM   3585 C CG2 . THR B 1 202 ? 133.238 113.898 149.760 1.00 110.56 ? 202 THR B CG2 1 
ATOM   3586 N N   . GLY B 1 203 ? 133.717 109.786 152.243 1.00 115.17 ? 203 GLY B N   1 
ATOM   3587 C CA  . GLY B 1 203 ? 134.445 108.594 152.620 1.00 115.17 ? 203 GLY B CA  1 
ATOM   3588 C C   . GLY B 1 203 ? 135.763 108.854 153.316 1.00 115.17 ? 203 GLY B C   1 
ATOM   3589 O O   . GLY B 1 203 ? 136.353 107.913 153.860 1.00 115.17 ? 203 GLY B O   1 
ATOM   3590 N N   . LYS B 1 204 ? 136.240 110.098 153.315 1.00 116.37 ? 204 LYS B N   1 
ATOM   3591 C CA  . LYS B 1 204 ? 137.476 110.462 153.997 1.00 116.37 ? 204 LYS B CA  1 
ATOM   3592 C C   . LYS B 1 204 ? 137.349 111.682 154.894 1.00 116.37 ? 204 LYS B C   1 
ATOM   3593 O O   . LYS B 1 204 ? 138.185 111.849 155.790 1.00 116.37 ? 204 LYS B O   1 
ATOM   3594 C CB  . LYS B 1 204 ? 138.599 110.716 152.980 1.00 116.37 ? 204 LYS B CB  1 
ATOM   3595 C CG  . LYS B 1 204 ? 139.019 109.485 152.193 1.00 116.37 ? 204 LYS B CG  1 
ATOM   3596 C CD  . LYS B 1 204 ? 140.052 109.833 151.133 1.00 116.37 ? 204 LYS B CD  1 
ATOM   3597 C CE  . LYS B 1 204 ? 140.458 108.607 150.333 1.00 116.37 ? 204 LYS B CE  1 
ATOM   3598 N NZ  . LYS B 1 204 ? 141.424 108.945 149.251 1.00 116.37 ? 204 LYS B NZ  1 
ATOM   3599 N N   . ASP B 1 205 ? 136.346 112.534 154.693 1.00 117.39 ? 205 ASP B N   1 
ATOM   3600 C CA  . ASP B 1 205 ? 136.161 113.726 155.504 1.00 117.39 ? 205 ASP B CA  1 
ATOM   3601 C C   . ASP B 1 205 ? 134.673 113.955 155.724 1.00 117.39 ? 205 ASP B C   1 
ATOM   3602 O O   . ASP B 1 205 ? 133.830 113.489 154.954 1.00 117.39 ? 205 ASP B O   1 
ATOM   3603 C CB  . ASP B 1 205 ? 136.800 114.960 154.853 1.00 117.39 ? 205 ASP B CB  1 
ATOM   3604 C CG  . ASP B 1 205 ? 136.425 115.107 153.391 1.00 117.39 ? 205 ASP B CG  1 
ATOM   3605 O OD1 . ASP B 1 205 ? 135.832 114.163 152.829 1.00 117.39 ? 205 ASP B OD1 1 
ATOM   3606 O OD2 . ASP B 1 205 ? 136.725 116.168 152.803 1.00 117.39 ? 205 ASP B OD2 1 
ATOM   3607 N N   . VAL B 1 206 ? 134.361 114.684 156.791 1.00 115.30 ? 206 VAL B N   1 
ATOM   3608 C CA  . VAL B 1 206 ? 132.989 115.006 157.165 1.00 115.30 ? 206 VAL B CA  1 
ATOM   3609 C C   . VAL B 1 206 ? 132.822 116.516 157.106 1.00 115.30 ? 206 VAL B C   1 
ATOM   3610 O O   . VAL B 1 206 ? 133.619 117.257 157.694 1.00 115.30 ? 206 VAL B O   1 
ATOM   3611 C CB  . VAL B 1 206 ? 132.641 114.468 158.566 1.00 115.30 ? 206 VAL B CB  1 
ATOM   3612 C CG1 . VAL B 1 206 ? 131.333 115.068 159.059 1.00 115.30 ? 206 VAL B CG1 1 
ATOM   3613 C CG2 . VAL B 1 206 ? 132.565 112.949 158.546 1.00 115.30 ? 206 VAL B CG2 1 
ATOM   3614 N N   . SER B 1 207 ? 131.790 116.970 156.400 1.00 110.61 ? 207 SER B N   1 
ATOM   3615 C CA  . SER B 1 207 ? 131.504 118.389 156.265 1.00 110.61 ? 207 SER B CA  1 
ATOM   3616 C C   . SER B 1 207 ? 130.024 118.635 156.508 1.00 110.61 ? 207 SER B C   1 
ATOM   3617 O O   . SER B 1 207 ? 129.176 117.802 156.179 1.00 110.61 ? 207 SER B O   1 
ATOM   3618 C CB  . SER B 1 207 ? 131.900 118.913 154.879 1.00 110.61 ? 207 SER B CB  1 
ATOM   3619 O OG  . SER B 1 207 ? 131.837 120.328 154.832 1.00 110.61 ? 207 SER B OG  1 
ATOM   3620 N N   . CYS B 1 208 ? 129.723 119.795 157.085 1.00 111.82 ? 208 CYS B N   1 
ATOM   3621 C CA  . CYS B 1 208 ? 128.360 120.205 157.386 1.00 111.82 ? 208 CYS B CA  1 
ATOM   3622 C C   . CYS B 1 208 ? 128.106 121.571 156.771 1.00 111.82 ? 208 CYS B C   1 
ATOM   3623 O O   . CYS B 1 208 ? 128.977 122.446 156.805 1.00 111.82 ? 208 CYS B O   1 
ATOM   3624 C CB  . CYS B 1 208 ? 128.113 120.261 158.898 1.00 111.82 ? 208 CYS B CB  1 
ATOM   3625 S SG  . CYS B 1 208 ? 128.857 118.903 159.830 1.00 111.82 ? 208 CYS B SG  1 
ATOM   3626 N N   . THR B 1 209 ? 126.913 121.754 156.212 1.00 110.00 ? 209 THR B N   1 
ATOM   3627 C CA  . THR B 1 209 ? 126.558 123.014 155.579 1.00 110.00 ? 209 THR B CA  1 
ATOM   3628 C C   . THR B 1 209 ? 125.086 123.308 155.818 1.00 110.00 ? 209 THR B C   1 
ATOM   3629 O O   . THR B 1 209 ? 124.254 122.397 155.816 1.00 110.00 ? 209 THR B O   1 
ATOM   3630 C CB  . THR B 1 209 ? 126.847 122.982 154.070 1.00 110.00 ? 209 THR B CB  1 
ATOM   3631 O OG1 . THR B 1 209 ? 128.163 122.461 153.843 1.00 110.00 ? 209 THR B OG1 1 
ATOM   3632 C CG2 . THR B 1 209 ? 126.758 124.379 153.472 1.00 110.00 ? 209 THR B CG2 1 
ATOM   3633 N N   . SER B 1 210 ? 124.775 124.587 156.020 1.00 106.72 ? 210 SER B N   1 
ATOM   3634 C CA  . SER B 1 210 ? 123.410 125.059 156.212 1.00 106.72 ? 210 SER B CA  1 
ATOM   3635 C C   . SER B 1 210 ? 123.084 126.039 155.096 1.00 106.72 ? 210 SER B C   1 
ATOM   3636 O O   . SER B 1 210 ? 123.776 127.049 154.933 1.00 106.72 ? 210 SER B O   1 
ATOM   3637 C CB  . SER B 1 210 ? 123.242 125.721 157.580 1.00 106.72 ? 210 SER B CB  1 
ATOM   3638 O OG  . SER B 1 210 ? 123.864 124.955 158.597 1.00 106.72 ? 210 SER B OG  1 
ATOM   3639 N N   . THR B 1 211 ? 122.037 125.742 154.328 1.00 104.06 ? 211 THR B N   1 
ATOM   3640 C CA  . THR B 1 211 ? 121.649 126.560 153.187 1.00 104.06 ? 211 THR B CA  1 
ATOM   3641 C C   . THR B 1 211 ? 120.164 126.874 153.262 1.00 104.06 ? 211 THR B C   1 
ATOM   3642 O O   . THR B 1 211 ? 119.346 125.980 153.500 1.00 104.06 ? 211 THR B O   1 
ATOM   3643 C CB  . THR B 1 211 ? 121.966 125.856 151.862 1.00 104.06 ? 211 THR B CB  1 
ATOM   3644 O OG1 . THR B 1 211 ? 121.406 124.537 151.875 1.00 104.06 ? 211 THR B OG1 1 
ATOM   3645 C CG2 . THR B 1 211 ? 123.470 125.764 151.651 1.00 104.06 ? 211 THR B CG2 1 
ATOM   3646 N N   . SER B 1 212 ? 119.822 128.142 153.054 1.00 98.59  ? 212 SER B N   1 
ATOM   3647 C CA  . SER B 1 212 ? 118.439 128.606 152.968 1.00 98.59  ? 212 SER B CA  1 
ATOM   3648 C C   . SER B 1 212 ? 118.226 129.151 151.560 1.00 98.59  ? 212 SER B C   1 
ATOM   3649 O O   . SER B 1 212 ? 118.639 130.274 151.253 1.00 98.59  ? 212 SER B O   1 
ATOM   3650 C CB  . SER B 1 212 ? 118.145 129.662 154.030 1.00 98.59  ? 212 SER B CB  1 
ATOM   3651 O OG  . SER B 1 212 ? 116.756 129.928 154.113 1.00 98.59  ? 212 SER B OG  1 
ATOM   3652 N N   . THR B 1 213 ? 117.584 128.359 150.707 1.00 89.95  ? 213 THR B N   1 
ATOM   3653 C CA  . THR B 1 213 ? 117.397 128.700 149.306 1.00 89.95  ? 213 THR B CA  1 
ATOM   3654 C C   . THR B 1 213 ? 115.914 128.769 148.973 1.00 89.95  ? 213 THR B C   1 
ATOM   3655 O O   . THR B 1 213 ? 115.094 128.054 149.555 1.00 89.95  ? 213 THR B O   1 
ATOM   3656 C CB  . THR B 1 213 ? 118.078 127.681 148.384 1.00 89.95  ? 213 THR B CB  1 
ATOM   3657 O OG1 . THR B 1 213 ? 117.444 126.404 148.530 1.00 89.95  ? 213 THR B OG1 1 
ATOM   3658 C CG2 . THR B 1 213 ? 119.555 127.552 148.729 1.00 89.95  ? 213 THR B CG2 1 
ATOM   3659 N N   . HIS B 1 214 ? 115.579 129.641 148.025 1.00 79.39  ? 214 HIS B N   1 
ATOM   3660 C CA  . HIS B 1 214 ? 114.213 129.790 147.543 1.00 79.39  ? 214 HIS B CA  1 
ATOM   3661 C C   . HIS B 1 214 ? 114.216 129.689 146.027 1.00 79.39  ? 214 HIS B C   1 
ATOM   3662 O O   . HIS B 1 214 ? 115.005 130.362 145.357 1.00 79.39  ? 214 HIS B O   1 
ATOM   3663 C CB  . HIS B 1 214 ? 113.607 131.128 147.978 1.00 79.39  ? 214 HIS B CB  1 
ATOM   3664 C CG  . HIS B 1 214 ? 112.285 131.426 147.342 1.00 79.39  ? 214 HIS B CG  1 
ATOM   3665 N ND1 . HIS B 1 214 ? 111.085 131.208 147.983 1.00 79.39  ? 214 HIS B ND1 1 
ATOM   3666 C CD2 . HIS B 1 214 ? 111.974 131.928 146.123 1.00 79.39  ? 214 HIS B CD2 1 
ATOM   3667 C CE1 . HIS B 1 214 ? 110.092 131.560 147.187 1.00 79.39  ? 214 HIS B CE1 1 
ATOM   3668 N NE2 . HIS B 1 214 ? 110.604 132.001 146.052 1.00 79.39  ? 214 HIS B NE2 1 
ATOM   3669 N N   . PHE B 1 215 ? 113.332 128.852 145.494 1.00 69.51  ? 215 PHE B N   1 
ATOM   3670 C CA  . PHE B 1 215 ? 113.205 128.701 144.055 1.00 69.51  ? 215 PHE B CA  1 
ATOM   3671 C C   . PHE B 1 215 ? 111.808 128.195 143.740 1.00 69.51  ? 215 PHE B C   1 
ATOM   3672 O O   . PHE B 1 215 ? 111.188 127.503 144.551 1.00 69.51  ? 215 PHE B O   1 
ATOM   3673 C CB  . PHE B 1 215 ? 114.261 127.742 143.496 1.00 69.51  ? 215 PHE B CB  1 
ATOM   3674 C CG  . PHE B 1 215 ? 114.131 126.334 144.003 1.00 69.51  ? 215 PHE B CG  1 
ATOM   3675 C CD1 . PHE B 1 215 ? 114.783 125.937 145.156 1.00 69.51  ? 215 PHE B CD1 1 
ATOM   3676 C CD2 . PHE B 1 215 ? 113.376 125.399 143.311 1.00 69.51  ? 215 PHE B CD2 1 
ATOM   3677 C CE1 . PHE B 1 215 ? 114.672 124.642 145.620 1.00 69.51  ? 215 PHE B CE1 1 
ATOM   3678 C CE2 . PHE B 1 215 ? 113.261 124.102 143.771 1.00 69.51  ? 215 PHE B CE2 1 
ATOM   3679 C CZ  . PHE B 1 215 ? 113.911 123.723 144.927 1.00 69.51  ? 215 PHE B CZ  1 
ATOM   3680 N N   . CYS B 1 216 ? 111.321 128.549 142.556 1.00 65.26  ? 216 CYS B N   1 
ATOM   3681 C CA  . CYS B 1 216 ? 110.043 128.065 142.056 1.00 65.26  ? 216 CYS B CA  1 
ATOM   3682 C C   . CYS B 1 216 ? 110.323 127.070 140.940 1.00 65.26  ? 216 CYS B C   1 
ATOM   3683 O O   . CYS B 1 216 ? 110.865 127.442 139.895 1.00 65.26  ? 216 CYS B O   1 
ATOM   3684 C CB  . CYS B 1 216 ? 109.178 129.218 141.553 1.00 65.26  ? 216 CYS B CB  1 
ATOM   3685 S SG  . CYS B 1 216 ? 109.974 130.253 140.305 1.00 65.26  ? 216 CYS B SG  1 
ATOM   3686 N N   . ALA B 1 217 ? 109.953 125.814 141.163 1.00 56.74  ? 217 ALA B N   1 
ATOM   3687 C CA  . ALA B 1 217 ? 110.225 124.757 140.200 1.00 56.74  ? 217 ALA B CA  1 
ATOM   3688 C C   . ALA B 1 217 ? 109.242 123.622 140.438 1.00 56.74  ? 217 ALA B C   1 
ATOM   3689 O O   . ALA B 1 217 ? 108.474 123.629 141.403 1.00 56.74  ? 217 ALA B O   1 
ATOM   3690 C CB  . ALA B 1 217 ? 111.670 124.263 140.306 1.00 56.74  ? 217 ALA B CB  1 
ATOM   3691 N N   . SER B 1 218 ? 109.277 122.644 139.543 1.00 50.03  ? 218 SER B N   1 
ATOM   3692 C CA  . SER B 1 218 ? 108.475 121.441 139.677 1.00 50.03  ? 218 SER B CA  1 
ATOM   3693 C C   . SER B 1 218 ? 109.325 120.310 140.246 1.00 50.03  ? 218 SER B C   1 
ATOM   3694 O O   . SER B 1 218 ? 110.556 120.365 140.261 1.00 50.03  ? 218 SER B O   1 
ATOM   3695 C CB  . SER B 1 218 ? 107.880 121.039 138.328 1.00 50.03  ? 218 SER B CB  1 
ATOM   3696 O OG  . SER B 1 218 ? 107.279 122.150 137.690 1.00 50.03  ? 218 SER B OG  1 
ATOM   3697 N N   . ARG B 1 219 ? 108.643 119.267 140.721 1.00 51.05  ? 219 ARG B N   1 
ATOM   3698 C CA  . ARG B 1 219 ? 109.346 118.110 141.259 1.00 51.05  ? 219 ARG B CA  1 
ATOM   3699 C C   . ARG B 1 219 ? 109.980 117.261 140.167 1.00 51.05  ? 219 ARG B C   1 
ATOM   3700 O O   . ARG B 1 219 ? 110.885 116.473 140.459 1.00 51.05  ? 219 ARG B O   1 
ATOM   3701 C CB  . ARG B 1 219 ? 108.390 117.258 142.094 1.00 51.05  ? 219 ARG B CB  1 
ATOM   3702 C CG  . ARG B 1 219 ? 109.056 116.513 143.237 1.00 51.05  ? 219 ARG B CG  1 
ATOM   3703 C CD  . ARG B 1 219 ? 108.027 115.808 144.105 1.00 51.05  ? 219 ARG B CD  1 
ATOM   3704 N NE  . ARG B 1 219 ? 107.297 114.788 143.363 1.00 51.05  ? 219 ARG B NE  1 
ATOM   3705 C CZ  . ARG B 1 219 ? 106.211 114.170 143.808 1.00 51.05  ? 219 ARG B CZ  1 
ATOM   3706 N NH1 . ARG B 1 219 ? 105.697 114.446 144.996 1.00 51.05  ? 219 ARG B NH1 1 
ATOM   3707 N NH2 . ARG B 1 219 ? 105.626 113.253 143.042 1.00 51.05  ? 219 ARG B NH2 1 
ATOM   3708 N N   . TYR B 1 220 ? 109.532 117.406 138.924 1.00 47.69  ? 220 TYR B N   1 
ATOM   3709 C CA  . TYR B 1 220 ? 110.043 116.658 137.781 1.00 47.69  ? 220 TYR B CA  1 
ATOM   3710 C C   . TYR B 1 220 ? 110.448 117.614 136.672 1.00 47.69  ? 220 TYR B C   1 
ATOM   3711 O O   . TYR B 1 220 ? 110.078 117.451 135.507 1.00 47.69  ? 220 TYR B O   1 
ATOM   3712 C CB  . TYR B 1 220 ? 109.008 115.654 137.282 1.00 47.69  ? 220 TYR B CB  1 
ATOM   3713 C CG  . TYR B 1 220 ? 108.835 114.454 138.184 1.00 47.69  ? 220 TYR B CG  1 
ATOM   3714 C CD1 . TYR B 1 220 ? 108.028 114.519 139.310 1.00 47.69  ? 220 TYR B CD1 1 
ATOM   3715 C CD2 . TYR B 1 220 ? 109.480 113.258 137.909 1.00 47.69  ? 220 TYR B CD2 1 
ATOM   3716 C CE1 . TYR B 1 220 ? 107.868 113.428 140.136 1.00 47.69  ? 220 TYR B CE1 1 
ATOM   3717 C CE2 . TYR B 1 220 ? 109.325 112.160 138.730 1.00 47.69  ? 220 TYR B CE2 1 
ATOM   3718 C CZ  . TYR B 1 220 ? 108.518 112.250 139.842 1.00 47.69  ? 220 TYR B CZ  1 
ATOM   3719 O OH  . TYR B 1 220 ? 108.361 111.157 140.664 1.00 47.69  ? 220 TYR B OH  1 
ATOM   3720 N N   . SER B 1 221 ? 111.218 118.641 137.036 1.00 45.33  ? 221 SER B N   1 
ATOM   3721 C CA  . SER B 1 221 ? 111.531 119.714 136.098 1.00 45.33  ? 221 SER B CA  1 
ATOM   3722 C C   . SER B 1 221 ? 112.278 119.192 134.879 1.00 45.33  ? 221 SER B C   1 
ATOM   3723 O O   . SER B 1 221 ? 111.950 119.543 133.738 1.00 45.33  ? 221 SER B O   1 
ATOM   3724 C CB  . SER B 1 221 ? 112.348 120.796 136.802 1.00 45.33  ? 221 SER B CB  1 
ATOM   3725 O OG  . SER B 1 221 ? 113.595 120.287 137.240 1.00 45.33  ? 221 SER B OG  1 
ATOM   3726 N N   . ASP B 1 222 ? 113.279 118.339 135.097 1.00 44.69  ? 222 ASP B N   1 
ATOM   3727 C CA  . ASP B 1 222 ? 114.069 117.853 133.973 1.00 44.69  ? 222 ASP B CA  1 
ATOM   3728 C C   . ASP B 1 222 ? 113.249 116.966 133.049 1.00 44.69  ? 222 ASP B C   1 
ATOM   3729 O O   . ASP B 1 222 ? 113.491 116.959 131.842 1.00 44.69  ? 222 ASP B O   1 
ATOM   3730 C CB  . ASP B 1 222 ? 115.304 117.106 134.473 1.00 44.69  ? 222 ASP B CB  1 
ATOM   3731 C CG  . ASP B 1 222 ? 116.214 117.980 135.313 1.00 44.69  ? 222 ASP B CG  1 
ATOM   3732 O OD1 . ASP B 1 222 ? 117.030 118.724 134.729 1.00 44.69  ? 222 ASP B OD1 1 
ATOM   3733 O OD2 . ASP B 1 222 ? 116.115 117.925 136.557 1.00 44.69  ? 222 ASP B OD2 1 
ATOM   3734 N N   . VAL B 1 223 ? 112.254 116.250 133.579 1.00 42.67  ? 223 VAL B N   1 
ATOM   3735 C CA  . VAL B 1 223 ? 111.378 115.450 132.724 1.00 42.67  ? 223 VAL B CA  1 
ATOM   3736 C C   . VAL B 1 223 ? 110.665 116.339 131.715 1.00 42.67  ? 223 VAL B C   1 
ATOM   3737 O O   . VAL B 1 223 ? 110.688 116.082 130.504 1.00 42.67  ? 223 VAL B O   1 
ATOM   3738 C CB  . VAL B 1 223 ? 110.370 114.661 133.577 1.00 42.67  ? 223 VAL B CB  1 
ATOM   3739 C CG1 . VAL B 1 223 ? 109.314 114.033 132.696 1.00 42.67  ? 223 VAL B CG1 1 
ATOM   3740 C CG2 . VAL B 1 223 ? 111.078 113.607 134.407 1.00 42.67  ? 223 VAL B CG2 1 
ATOM   3741 N N   . TRP B 1 224 ? 110.039 117.414 132.197 1.00 41.57  ? 224 TRP B N   1 
ATOM   3742 C CA  . TRP B 1 224 ? 109.272 118.284 131.313 1.00 41.57  ? 224 TRP B CA  1 
ATOM   3743 C C   . TRP B 1 224 ? 110.175 119.056 130.366 1.00 41.57  ? 224 TRP B C   1 
ATOM   3744 O O   . TRP B 1 224 ? 109.862 119.193 129.175 1.00 41.57  ? 224 TRP B O   1 
ATOM   3745 C CB  . TRP B 1 224 ? 108.422 119.241 132.140 1.00 41.57  ? 224 TRP B CB  1 
ATOM   3746 C CG  . TRP B 1 224 ? 107.497 118.547 133.070 1.00 41.57  ? 224 TRP B CG  1 
ATOM   3747 C CD1 . TRP B 1 224 ? 107.484 118.637 134.425 1.00 41.57  ? 224 TRP B CD1 1 
ATOM   3748 C CD2 . TRP B 1 224 ? 106.431 117.663 132.716 1.00 41.57  ? 224 TRP B CD2 1 
ATOM   3749 N NE1 . TRP B 1 224 ? 106.484 117.857 134.941 1.00 41.57  ? 224 TRP B NE1 1 
ATOM   3750 C CE2 . TRP B 1 224 ? 105.822 117.248 133.910 1.00 41.57  ? 224 TRP B CE2 1 
ATOM   3751 C CE3 . TRP B 1 224 ? 105.938 117.178 131.505 1.00 41.57  ? 224 TRP B CE3 1 
ATOM   3752 C CZ2 . TRP B 1 224 ? 104.746 116.375 133.929 1.00 41.57  ? 224 TRP B CZ2 1 
ATOM   3753 C CZ3 . TRP B 1 224 ? 104.872 116.313 131.526 1.00 41.57  ? 224 TRP B CZ3 1 
ATOM   3754 C CH2 . TRP B 1 224 ? 104.286 115.919 132.729 1.00 41.57  ? 224 TRP B CH2 1 
ATOM   3755 N N   . ILE B 1 225 ? 111.293 119.575 130.876 1.00 42.47  ? 225 ILE B N   1 
ATOM   3756 C CA  . ILE B 1 225 ? 112.236 120.285 130.018 1.00 42.47  ? 225 ILE B CA  1 
ATOM   3757 C C   . ILE B 1 225 ? 112.734 119.365 128.915 1.00 42.47  ? 225 ILE B C   1 
ATOM   3758 O O   . ILE B 1 225 ? 112.764 119.738 127.738 1.00 42.47  ? 225 ILE B O   1 
ATOM   3759 C CB  . ILE B 1 225 ? 113.394 120.865 130.847 1.00 42.47  ? 225 ILE B CB  1 
ATOM   3760 C CG1 . ILE B 1 225 ? 112.846 121.862 131.866 1.00 42.47  ? 225 ILE B CG1 1 
ATOM   3761 C CG2 . ILE B 1 225 ? 114.411 121.530 129.941 1.00 42.47  ? 225 ILE B CG2 1 
ATOM   3762 C CD1 . ILE B 1 225 ? 113.896 122.657 132.586 1.00 42.47  ? 225 ILE B CD1 1 
ATOM   3763 N N   . ALA B 1 226 ? 113.115 118.139 129.279 1.00 40.25  ? 226 ALA B N   1 
ATOM   3764 C CA  . ALA B 1 226 ? 113.623 117.195 128.296 1.00 40.25  ? 226 ALA B CA  1 
ATOM   3765 C C   . ALA B 1 226 ? 112.562 116.852 127.266 1.00 40.25  ? 226 ALA B C   1 
ATOM   3766 O O   . ALA B 1 226 ? 112.853 116.809 126.072 1.00 40.25  ? 226 ALA B O   1 
ATOM   3767 C CB  . ALA B 1 226 ? 114.125 115.935 128.995 1.00 40.25  ? 226 ALA B CB  1 
ATOM   3768 N N   . LEU B 1 227 ? 111.321 116.626 127.698 1.00 40.31  ? 227 LEU B N   1 
ATOM   3769 C CA  . LEU B 1 227 ? 110.276 116.252 126.749 1.00 40.31  ? 227 LEU B CA  1 
ATOM   3770 C C   . LEU B 1 227 ? 109.985 117.387 125.773 1.00 40.31  ? 227 LEU B C   1 
ATOM   3771 O O   . LEU B 1 227 ? 109.948 117.177 124.552 1.00 40.31  ? 227 LEU B O   1 
ATOM   3772 C CB  . LEU B 1 227 ? 109.015 115.840 127.504 1.00 40.31  ? 227 LEU B CB  1 
ATOM   3773 C CG  . LEU B 1 227 ? 107.854 115.286 126.684 1.00 40.31  ? 227 LEU B CG  1 
ATOM   3774 C CD1 . LEU B 1 227 ? 108.167 113.886 126.188 1.00 40.31  ? 227 LEU B CD1 1 
ATOM   3775 C CD2 . LEU B 1 227 ? 106.584 115.285 127.516 1.00 40.31  ? 227 LEU B CD2 1 
ATOM   3776 N N   . ILE B 1 228 ? 109.800 118.604 126.288 1.00 41.52  ? 228 ILE B N   1 
ATOM   3777 C CA  . ILE B 1 228 ? 109.468 119.731 125.420 1.00 41.52  ? 228 ILE B CA  1 
ATOM   3778 C C   . ILE B 1 228 ? 110.624 120.040 124.477 1.00 41.52  ? 228 ILE B C   1 
ATOM   3779 O O   . ILE B 1 228 ? 110.437 120.192 123.262 1.00 41.52  ? 228 ILE B O   1 
ATOM   3780 C CB  . ILE B 1 228 ? 109.087 120.962 126.261 1.00 41.52  ? 228 ILE B CB  1 
ATOM   3781 C CG1 . ILE B 1 228 ? 107.752 120.735 126.972 1.00 41.52  ? 228 ILE B CG1 1 
ATOM   3782 C CG2 . ILE B 1 228 ? 109.031 122.202 125.388 1.00 41.52  ? 228 ILE B CG2 1 
ATOM   3783 C CD1 . ILE B 1 228 ? 106.550 120.932 126.086 1.00 41.52  ? 228 ILE B CD1 1 
ATOM   3784 N N   . TRP B 1 229 ? 111.840 120.132 125.020 1.00 43.39  ? 229 TRP B N   1 
ATOM   3785 C CA  . TRP B 1 229 ? 112.997 120.452 124.198 1.00 43.39  ? 229 TRP B CA  1 
ATOM   3786 C C   . TRP B 1 229 ? 113.344 119.322 123.241 1.00 43.39  ? 229 TRP B C   1 
ATOM   3787 O O   . TRP B 1 229 ? 113.887 119.583 122.170 1.00 43.39  ? 229 TRP B O   1 
ATOM   3788 C CB  . TRP B 1 229 ? 114.187 120.801 125.090 1.00 43.39  ? 229 TRP B CB  1 
ATOM   3789 C CG  . TRP B 1 229 ? 113.988 122.049 125.915 1.00 43.39  ? 229 TRP B CG  1 
ATOM   3790 C CD1 . TRP B 1 229 ? 112.825 122.489 126.482 1.00 43.39  ? 229 TRP B CD1 1 
ATOM   3791 C CD2 . TRP B 1 229 ? 114.995 123.000 126.284 1.00 43.39  ? 229 TRP B CD2 1 
ATOM   3792 N NE1 . TRP B 1 229 ? 113.042 123.662 127.162 1.00 43.39  ? 229 TRP B NE1 1 
ATOM   3793 C CE2 . TRP B 1 229 ? 114.366 123.996 127.058 1.00 43.39  ? 229 TRP B CE2 1 
ATOM   3794 C CE3 . TRP B 1 229 ? 116.365 123.110 126.029 1.00 43.39  ? 229 TRP B CE3 1 
ATOM   3795 C CZ2 . TRP B 1 229 ? 115.060 125.083 127.581 1.00 43.39  ? 229 TRP B CZ2 1 
ATOM   3796 C CZ3 . TRP B 1 229 ? 117.051 124.189 126.550 1.00 43.39  ? 229 TRP B CZ3 1 
ATOM   3797 C CH2 . TRP B 1 229 ? 116.397 125.162 127.316 1.00 43.39  ? 229 TRP B CH2 1 
ATOM   3798 N N   . GLY B 1 230 ? 113.009 118.075 123.574 1.00 41.49  ? 230 GLY B N   1 
ATOM   3799 C CA  . GLY B 1 230 ? 113.232 116.986 122.639 1.00 41.49  ? 230 GLY B CA  1 
ATOM   3800 C C   . GLY B 1 230 ? 112.254 117.002 121.483 1.00 41.49  ? 230 GLY B C   1 
ATOM   3801 O O   . GLY B 1 230 ? 112.631 116.741 120.336 1.00 41.49  ? 230 GLY B O   1 
ATOM   3802 N N   . CYS B 1 231 ? 110.983 117.302 121.762 1.00 43.47  ? 231 CYS B N   1 
ATOM   3803 C CA  . CYS B 1 231 ? 110.025 117.475 120.673 1.00 43.47  ? 231 CYS B CA  1 
ATOM   3804 C C   . CYS B 1 231 ? 110.444 118.628 119.766 1.00 43.47  ? 231 CYS B C   1 
ATOM   3805 O O   . CYS B 1 231 ? 110.452 118.503 118.531 1.00 43.47  ? 231 CYS B O   1 
ATOM   3806 C CB  . CYS B 1 231 ? 108.625 117.706 121.239 1.00 43.47  ? 231 CYS B CB  1 
ATOM   3807 S SG  . CYS B 1 231 ? 107.927 116.279 122.097 1.00 43.47  ? 231 CYS B SG  1 
ATOM   3808 N N   . LYS B 1 232 ? 110.833 119.754 120.368 1.00 41.35  ? 232 LYS B N   1 
ATOM   3809 C CA  . LYS B 1 232 ? 111.317 120.876 119.575 1.00 41.35  ? 232 LYS B CA  1 
ATOM   3810 C C   . LYS B 1 232 ? 112.600 120.525 118.834 1.00 41.35  ? 232 LYS B C   1 
ATOM   3811 O O   . LYS B 1 232 ? 112.822 121.010 117.723 1.00 41.35  ? 232 LYS B O   1 
ATOM   3812 C CB  . LYS B 1 232 ? 111.529 122.099 120.465 1.00 41.35  ? 232 LYS B CB  1 
ATOM   3813 C CG  . LYS B 1 232 ? 111.368 123.423 119.739 1.00 41.35  ? 232 LYS B CG  1 
ATOM   3814 C CD  . LYS B 1 232 ? 109.912 123.702 119.409 1.00 41.35  ? 232 LYS B CD  1 
ATOM   3815 C CE  . LYS B 1 232 ? 109.051 123.700 120.657 1.00 41.35  ? 232 LYS B CE  1 
ATOM   3816 N NZ  . LYS B 1 232 ? 107.602 123.689 120.320 1.00 41.35  ? 232 LYS B NZ  1 
ATOM   3817 N N   . GLY B 1 233 ? 113.443 119.672 119.416 1.00 42.25  ? 233 GLY B N   1 
ATOM   3818 C CA  . GLY B 1 233 ? 114.659 119.258 118.739 1.00 42.25  ? 233 GLY B CA  1 
ATOM   3819 C C   . GLY B 1 233 ? 114.389 118.392 117.528 1.00 42.25  ? 233 GLY B C   1 
ATOM   3820 O O   . GLY B 1 233 ? 115.061 118.521 116.503 1.00 42.25  ? 233 GLY B O   1 
ATOM   3821 N N   . LEU B 1 234 ? 113.419 117.486 117.632 1.00 40.73  ? 234 LEU B N   1 
ATOM   3822 C CA  . LEU B 1 234 ? 113.023 116.707 116.464 1.00 40.73  ? 234 LEU B CA  1 
ATOM   3823 C C   . LEU B 1 234 ? 112.460 117.616 115.381 1.00 40.73  ? 234 LEU B C   1 
ATOM   3824 O O   . LEU B 1 234 ? 112.749 117.436 114.188 1.00 40.73  ? 234 LEU B O   1 
ATOM   3825 C CB  . LEU B 1 234 ? 112.009 115.634 116.858 1.00 40.73  ? 234 LEU B CB  1 
ATOM   3826 C CG  . LEU B 1 234 ? 112.516 114.561 117.825 1.00 40.73  ? 234 LEU B CG  1 
ATOM   3827 C CD1 . LEU B 1 234 ? 111.428 113.542 118.115 1.00 40.73  ? 234 LEU B CD1 1 
ATOM   3828 C CD2 . LEU B 1 234 ? 113.753 113.882 117.270 1.00 40.73  ? 234 LEU B CD2 1 
ATOM   3829 N N   . LEU B 1 235 ? 111.667 118.615 115.782 1.00 39.70  ? 235 LEU B N   1 
ATOM   3830 C CA  . LEU B 1 235 ? 111.189 119.602 114.817 1.00 39.70  ? 235 LEU B CA  1 
ATOM   3831 C C   . LEU B 1 235 ? 112.347 120.333 114.145 1.00 39.70  ? 235 LEU B C   1 
ATOM   3832 O O   . LEU B 1 235 ? 112.343 120.527 112.926 1.00 39.70  ? 235 LEU B O   1 
ATOM   3833 C CB  . LEU B 1 235 ? 110.267 120.604 115.503 1.00 39.70  ? 235 LEU B CB  1 
ATOM   3834 C CG  . LEU B 1 235 ? 109.668 121.640 114.557 1.00 39.70  ? 235 LEU B CG  1 
ATOM   3835 C CD1 . LEU B 1 235 ? 108.794 120.953 113.522 1.00 39.70  ? 235 LEU B CD1 1 
ATOM   3836 C CD2 . LEU B 1 235 ? 108.899 122.703 115.322 1.00 39.70  ? 235 LEU B CD2 1 
ATOM   3837 N N   . LEU B 1 236 ? 113.348 120.746 114.925 1.00 39.74  ? 236 LEU B N   1 
ATOM   3838 C CA  . LEU B 1 236 ? 114.478 121.481 114.364 1.00 39.74  ? 236 LEU B CA  1 
ATOM   3839 C C   . LEU B 1 236 ? 115.312 120.602 113.445 1.00 39.74  ? 236 LEU B C   1 
ATOM   3840 O O   . LEU B 1 236 ? 115.843 121.078 112.438 1.00 39.74  ? 236 LEU B O   1 
ATOM   3841 C CB  . LEU B 1 236 ? 115.353 122.057 115.477 1.00 39.74  ? 236 LEU B CB  1 
ATOM   3842 C CG  . LEU B 1 236 ? 114.733 123.040 116.468 1.00 39.74  ? 236 LEU B CG  1 
ATOM   3843 C CD1 . LEU B 1 236 ? 115.813 123.726 117.283 1.00 39.74  ? 236 LEU B CD1 1 
ATOM   3844 C CD2 . LEU B 1 236 ? 113.877 124.065 115.741 1.00 39.74  ? 236 LEU B CD2 1 
ATOM   3845 N N   . LEU B 1 237 ? 115.460 119.323 113.785 1.00 39.14  ? 237 LEU B N   1 
ATOM   3846 C CA  . LEU B 1 237 ? 116.191 118.410 112.915 1.00 39.14  ? 237 LEU B CA  1 
ATOM   3847 C C   . LEU B 1 237 ? 115.469 118.211 111.590 1.00 39.14  ? 237 LEU B C   1 
ATOM   3848 O O   . LEU B 1 237 ? 116.101 118.217 110.525 1.00 39.14  ? 237 LEU B O   1 
ATOM   3849 C CB  . LEU B 1 237 ? 116.395 117.078 113.623 1.00 39.14  ? 237 LEU B CB  1 
ATOM   3850 C CG  . LEU B 1 237 ? 117.405 117.179 114.759 1.00 39.14  ? 237 LEU B CG  1 
ATOM   3851 C CD1 . LEU B 1 237 ? 117.267 116.002 115.705 1.00 39.14  ? 237 LEU B CD1 1 
ATOM   3852 C CD2 . LEU B 1 237 ? 118.810 117.289 114.206 1.00 39.14  ? 237 LEU B CD2 1 
ATOM   3853 N N   . TYR B 1 238 ? 114.144 118.052 111.627 1.00 38.81  ? 238 TYR B N   1 
ATOM   3854 C CA  . TYR B 1 238 ? 113.413 117.957 110.367 1.00 38.81  ? 238 TYR B CA  1 
ATOM   3855 C C   . TYR B 1 238 ? 113.464 119.267 109.592 1.00 38.81  ? 238 TYR B C   1 
ATOM   3856 O O   . TYR B 1 238 ? 113.488 119.254 108.357 1.00 38.81  ? 238 TYR B O   1 
ATOM   3857 C CB  . TYR B 1 238 ? 111.966 117.540 110.604 1.00 38.81  ? 238 TYR B CB  1 
ATOM   3858 C CG  . TYR B 1 238 ? 111.256 117.181 109.321 1.00 38.81  ? 238 TYR B CG  1 
ATOM   3859 C CD1 . TYR B 1 238 ? 111.787 116.236 108.458 1.00 38.81  ? 238 TYR B CD1 1 
ATOM   3860 C CD2 . TYR B 1 238 ? 110.068 117.798 108.964 1.00 38.81  ? 238 TYR B CD2 1 
ATOM   3861 C CE1 . TYR B 1 238 ? 111.152 115.907 107.280 1.00 38.81  ? 238 TYR B CE1 1 
ATOM   3862 C CE2 . TYR B 1 238 ? 109.424 117.475 107.786 1.00 38.81  ? 238 TYR B CE2 1 
ATOM   3863 C CZ  . TYR B 1 238 ? 109.971 116.529 106.948 1.00 38.81  ? 238 TYR B CZ  1 
ATOM   3864 O OH  . TYR B 1 238 ? 109.336 116.201 105.774 1.00 38.81  ? 238 TYR B OH  1 
ATOM   3865 N N   . GLY B 1 239 ? 113.500 120.400 110.290 1.00 36.69  ? 239 GLY B N   1 
ATOM   3866 C CA  . GLY B 1 239 ? 113.651 121.672 109.606 1.00 36.69  ? 239 GLY B CA  1 
ATOM   3867 C C   . GLY B 1 239 ? 115.002 121.824 108.940 1.00 36.69  ? 239 GLY B C   1 
ATOM   3868 O O   . GLY B 1 239 ? 115.103 122.372 107.841 1.00 36.69  ? 239 GLY B O   1 
ATOM   3869 N N   . ALA B 1 240 ? 116.060 121.355 109.599 1.00 37.48  ? 240 ALA B N   1 
ATOM   3870 C CA  . ALA B 1 240 ? 117.380 121.359 108.981 1.00 37.48  ? 240 ALA B CA  1 
ATOM   3871 C C   . ALA B 1 240 ? 117.420 120.441 107.768 1.00 37.48  ? 240 ALA B C   1 
ATOM   3872 O O   . ALA B 1 240 ? 118.025 120.777 106.745 1.00 37.48  ? 240 ALA B O   1 
ATOM   3873 C CB  . ALA B 1 240 ? 118.438 120.945 110.001 1.00 37.48  ? 240 ALA B CB  1 
ATOM   3874 N N   . TYR B 1 241 ? 116.770 119.281 107.859 1.00 37.13  ? 241 TYR B N   1 
ATOM   3875 C CA  . TYR B 1 241 ? 116.665 118.402 106.698 1.00 37.13  ? 241 TYR B CA  1 
ATOM   3876 C C   . TYR B 1 241 ? 115.933 119.085 105.548 1.00 37.13  ? 241 TYR B C   1 
ATOM   3877 O O   . TYR B 1 241 ? 116.359 118.998 104.389 1.00 37.13  ? 241 TYR B O   1 
ATOM   3878 C CB  . TYR B 1 241 ? 115.993 117.092 107.118 1.00 37.13  ? 241 TYR B CB  1 
ATOM   3879 C CG  . TYR B 1 241 ? 115.671 116.100 106.020 1.00 37.13  ? 241 TYR B CG  1 
ATOM   3880 C CD1 . TYR B 1 241 ? 114.634 116.311 105.129 1.00 37.13  ? 241 TYR B CD1 1 
ATOM   3881 C CD2 . TYR B 1 241 ? 116.437 114.962 105.857 1.00 37.13  ? 241 TYR B CD2 1 
ATOM   3882 C CE1 . TYR B 1 241 ? 114.352 115.398 104.140 1.00 37.13  ? 241 TYR B CE1 1 
ATOM   3883 C CE2 . TYR B 1 241 ? 116.170 114.052 104.870 1.00 37.13  ? 241 TYR B CE2 1 
ATOM   3884 C CZ  . TYR B 1 241 ? 115.129 114.274 104.010 1.00 37.13  ? 241 TYR B CZ  1 
ATOM   3885 O OH  . TYR B 1 241 ? 114.860 113.362 103.016 1.00 37.13  ? 241 TYR B OH  1 
ATOM   3886 N N   . LEU B 1 242 ? 114.830 119.772 105.846 1.00 37.05  ? 242 LEU B N   1 
ATOM   3887 C CA  . LEU B 1 242 ? 114.069 120.439 104.794 1.00 37.05  ? 242 LEU B CA  1 
ATOM   3888 C C   . LEU B 1 242 ? 114.850 121.601 104.195 1.00 37.05  ? 242 LEU B C   1 
ATOM   3889 O O   . LEU B 1 242 ? 114.769 121.852 102.987 1.00 37.05  ? 242 LEU B O   1 
ATOM   3890 C CB  . LEU B 1 242 ? 112.727 120.917 105.339 1.00 37.05  ? 242 LEU B CB  1 
ATOM   3891 C CG  . LEU B 1 242 ? 111.556 119.970 105.092 1.00 37.05  ? 242 LEU B CG  1 
ATOM   3892 C CD1 . LEU B 1 242 ? 110.302 120.488 105.770 1.00 37.05  ? 242 LEU B CD1 1 
ATOM   3893 C CD2 . LEU B 1 242 ? 111.330 119.794 103.607 1.00 37.05  ? 242 LEU B CD2 1 
ATOM   3894 N N   . ALA B 1 243 ? 115.604 122.326 105.022 1.00 36.76  ? 243 ALA B N   1 
ATOM   3895 C CA  . ALA B 1 243 ? 116.497 123.351 104.499 1.00 36.76  ? 243 ALA B CA  1 
ATOM   3896 C C   . ALA B 1 243 ? 117.579 122.742 103.626 1.00 36.76  ? 243 ALA B C   1 
ATOM   3897 O O   . ALA B 1 243 ? 118.021 123.368 102.657 1.00 36.76  ? 243 ALA B O   1 
ATOM   3898 C CB  . ALA B 1 243 ? 117.126 124.139 105.644 1.00 36.76  ? 243 ALA B CB  1 
ATOM   3899 N N   . GLY B 1 244 ? 118.026 121.532 103.958 1.00 36.68  ? 244 GLY B N   1 
ATOM   3900 C CA  . GLY B 1 244 ? 118.984 120.856 103.104 1.00 36.68  ? 244 GLY B CA  1 
ATOM   3901 C C   . GLY B 1 244 ? 118.406 120.491 101.751 1.00 36.68  ? 244 GLY B C   1 
ATOM   3902 O O   . GLY B 1 244 ? 119.062 120.667 100.721 1.00 36.68  ? 244 GLY B O   1 
ATOM   3903 N N   . LEU B 1 245 ? 117.176 119.970 101.731 1.00 36.04  ? 245 LEU B N   1 
ATOM   3904 C CA  . LEU B 1 245 ? 116.556 119.614 100.457 1.00 36.04  ? 245 LEU B CA  1 
ATOM   3905 C C   . LEU B 1 245 ? 116.375 120.834 99.568  1.00 36.04  ? 245 LEU B C   1 
ATOM   3906 O O   . LEU B 1 245 ? 116.677 120.791 98.370  1.00 36.04  ? 245 LEU B O   1 
ATOM   3907 C CB  . LEU B 1 245 ? 115.209 118.936 100.677 1.00 36.04  ? 245 LEU B CB  1 
ATOM   3908 C CG  . LEU B 1 245 ? 115.151 117.502 101.181 1.00 36.04  ? 245 LEU B CG  1 
ATOM   3909 C CD1 . LEU B 1 245 ? 113.698 117.130 101.373 1.00 36.04  ? 245 LEU B CD1 1 
ATOM   3910 C CD2 . LEU B 1 245 ? 115.823 116.561 100.203 1.00 36.04  ? 245 LEU B CD2 1 
ATOM   3911 N N   . THR B 1 246 ? 115.885 121.932 100.137 1.00 37.48  ? 246 THR B N   1 
ATOM   3912 C CA  . THR B 1 246 ? 115.578 123.135 99.382  1.00 37.48  ? 246 THR B CA  1 
ATOM   3913 C C   . THR B 1 246 ? 116.731 124.132 99.364  1.00 37.48  ? 246 THR B C   1 
ATOM   3914 O O   . THR B 1 246 ? 116.522 125.294 99.007  1.00 37.48  ? 246 THR B O   1 
ATOM   3915 C CB  . THR B 1 246 ? 114.326 123.797 99.950  1.00 37.48  ? 246 THR B CB  1 
ATOM   3916 O OG1 . THR B 1 246 ? 114.641 124.408 101.205 1.00 37.48  ? 246 THR B OG1 1 
ATOM   3917 C CG2 . THR B 1 246 ? 113.241 122.763 100.161 1.00 37.48  ? 246 THR B CG2 1 
ATOM   3918 N N   . GLY B 1 247 ? 117.942 123.694 99.716  1.00 39.67  ? 247 GLY B N   1 
ATOM   3919 C CA  . GLY B 1 247 ? 119.042 124.629 99.889  1.00 39.67  ? 247 GLY B CA  1 
ATOM   3920 C C   . GLY B 1 247 ? 119.414 125.368 98.618  1.00 39.67  ? 247 GLY B C   1 
ATOM   3921 O O   . GLY B 1 247 ? 119.694 126.569 98.647  1.00 39.67  ? 247 GLY B O   1 
ATOM   3922 N N   . HIS B 1 248 ? 119.428 124.667 97.489  1.00 43.37  ? 248 HIS B N   1 
ATOM   3923 C CA  . HIS B 1 248 ? 119.832 125.281 96.232  1.00 43.37  ? 248 HIS B CA  1 
ATOM   3924 C C   . HIS B 1 248 ? 118.740 125.113 95.187  1.00 43.37  ? 248 HIS B C   1 
ATOM   3925 O O   . HIS B 1 248 ? 119.012 124.706 94.053  1.00 43.37  ? 248 HIS B O   1 
ATOM   3926 C CB  . HIS B 1 248 ? 121.147 124.680 95.733  1.00 43.37  ? 248 HIS B CB  1 
ATOM   3927 C CG  . HIS B 1 248 ? 122.241 124.687 96.755  1.00 43.37  ? 248 HIS B CG  1 
ATOM   3928 N ND1 . HIS B 1 248 ? 122.818 125.850 97.219  1.00 43.37  ? 248 HIS B ND1 1 
ATOM   3929 C CD2 . HIS B 1 248 ? 122.865 123.674 97.400  1.00 43.37  ? 248 HIS B CD2 1 
ATOM   3930 C CE1 . HIS B 1 248 ? 123.749 125.553 98.107  1.00 43.37  ? 248 HIS B CE1 1 
ATOM   3931 N NE2 . HIS B 1 248 ? 123.798 124.239 98.235  1.00 43.37  ? 248 HIS B NE2 1 
ATOM   3932 N N   . VAL B 1 249 ? 117.503 125.429 95.559  1.00 41.51  ? 249 VAL B N   1 
ATOM   3933 C CA  . VAL B 1 249 ? 116.360 125.146 94.714  1.00 41.51  ? 249 VAL B CA  1 
ATOM   3934 C C   . VAL B 1 249 ? 115.689 126.409 94.181  1.00 41.51  ? 249 VAL B C   1 
ATOM   3935 O O   . VAL B 1 249 ? 115.150 126.383 93.068  1.00 41.51  ? 249 VAL B O   1 
ATOM   3936 C CB  . VAL B 1 249 ? 115.346 124.261 95.470  1.00 41.51  ? 249 VAL B CB  1 
ATOM   3937 C CG1 . VAL B 1 249 ? 114.109 124.014 94.639  1.00 41.51  ? 249 VAL B CG1 1 
ATOM   3938 C CG2 . VAL B 1 249 ? 115.990 122.937 95.845  1.00 41.51  ? 249 VAL B CG2 1 
ATOM   3939 N N   . SER B 1 250 ? 115.742 127.521 94.905  1.00 43.03  ? 250 SER B N   1 
ATOM   3940 C CA  . SER B 1 250 ? 115.011 128.707 94.484  1.00 43.03  ? 250 SER B CA  1 
ATOM   3941 C C   . SER B 1 250 ? 115.802 129.952 94.866  1.00 43.03  ? 250 SER B C   1 
ATOM   3942 O O   . SER B 1 250 ? 116.968 129.877 95.264  1.00 43.03  ? 250 SER B O   1 
ATOM   3943 C CB  . SER B 1 250 ? 113.605 128.717 95.094  1.00 43.03  ? 250 SER B CB  1 
ATOM   3944 O OG  . SER B 1 250 ? 113.654 129.032 96.475  1.00 43.03  ? 250 SER B OG  1 
ATOM   3945 N N   . SER B 1 251 ? 115.151 131.104 94.734  1.00 45.83  ? 251 SER B N   1 
ATOM   3946 C CA  . SER B 1 251 ? 115.755 132.386 95.028  1.00 45.83  ? 251 SER B CA  1 
ATOM   3947 C C   . SER B 1 251 ? 115.853 132.583 96.546  1.00 45.83  ? 251 SER B C   1 
ATOM   3948 O O   . SER B 1 251 ? 115.145 131.922 97.312  1.00 45.83  ? 251 SER B O   1 
ATOM   3949 C CB  . SER B 1 251 ? 114.924 133.492 94.371  1.00 45.83  ? 251 SER B CB  1 
ATOM   3950 O OG  . SER B 1 251 ? 115.473 134.782 94.561  1.00 45.83  ? 251 SER B OG  1 
ATOM   3951 N N   . PRO B 1 252 ? 116.687 133.461 97.040  1.00 46.17  ? 252 PRO B N   1 
ATOM   3952 C CA  . PRO B 1 252 ? 116.627 133.565 98.511  1.00 46.17  ? 252 PRO B CA  1 
ATOM   3953 C C   . PRO B 1 252 ? 115.292 134.003 99.042  1.00 46.17  ? 252 PRO B C   1 
ATOM   3954 O O   . PRO B 1 252 ? 114.874 133.430 100.032 1.00 46.17  ? 252 PRO B O   1 
ATOM   3955 C CB  . PRO B 1 252 ? 117.659 134.621 98.837  1.00 46.17  ? 252 PRO B CB  1 
ATOM   3956 C CG  . PRO B 1 252 ? 118.630 134.567 97.702  1.00 46.17  ? 252 PRO B CG  1 
ATOM   3957 C CD  . PRO B 1 252 ? 117.846 134.178 96.479  1.00 46.17  ? 252 PRO B CD  1 
ATOM   3958 N N   . PRO B 1 253 ? 114.629 134.995 98.446  1.00 45.65  ? 253 PRO B N   1 
ATOM   3959 C CA  . PRO B 1 253 ? 113.375 135.521 98.994  1.00 45.65  ? 253 PRO B CA  1 
ATOM   3960 C C   . PRO B 1 253 ? 112.335 134.469 99.186  1.00 45.65  ? 253 PRO B C   1 
ATOM   3961 O O   . PRO B 1 253 ? 111.296 134.805 99.720  1.00 45.65  ? 253 PRO B O   1 
ATOM   3962 C CB  . PRO B 1 253 ? 112.893 136.427 97.897  1.00 45.65  ? 253 PRO B CB  1 
ATOM   3963 C CG  . PRO B 1 253 ? 114.136 136.957 97.287  1.00 45.65  ? 253 PRO B CG  1 
ATOM   3964 C CD  . PRO B 1 253 ? 115.090 135.803 97.304  1.00 45.65  ? 253 PRO B CD  1 
ATOM   3965 N N   . VAL B 1 254 ? 112.600 133.229 98.800  1.00 43.60  ? 254 VAL B N   1 
ATOM   3966 C CA  . VAL B 1 254 ? 111.660 132.120 98.870  1.00 43.60  ? 254 VAL B CA  1 
ATOM   3967 C C   . VAL B 1 254 ? 112.302 130.849 99.413  1.00 43.60  ? 254 VAL B C   1 
ATOM   3968 O O   . VAL B 1 254 ? 111.591 130.007 99.984  1.00 43.60  ? 254 VAL B O   1 
ATOM   3969 C CB  . VAL B 1 254 ? 111.033 131.854 97.484  1.00 43.60  ? 254 VAL B CB  1 
ATOM   3970 C CG1 . VAL B 1 254 ? 109.987 130.750 97.541  1.00 43.60  ? 254 VAL B CG1 1 
ATOM   3971 C CG2 . VAL B 1 254 ? 110.449 133.132 96.918  1.00 43.60  ? 254 VAL B CG2 1 
ATOM   3972 N N   . ASN B 1 255 ? 113.624 130.697 99.294  1.00 41.83  ? 255 ASN B N   1 
ATOM   3973 C CA  . ASN B 1 255 ? 114.299 129.467 99.697  1.00 41.83  ? 255 ASN B CA  1 
ATOM   3974 C C   . ASN B 1 255 ? 114.115 129.183 101.184 1.00 41.83  ? 255 ASN B C   1 
ATOM   3975 O O   . ASN B 1 255 ? 113.721 128.076 101.570 1.00 41.83  ? 255 ASN B O   1 
ATOM   3976 C CB  . ASN B 1 255 ? 115.782 129.572 99.345  1.00 41.83  ? 255 ASN B CB  1 
ATOM   3977 C CG  . ASN B 1 255 ? 116.517 128.265 99.503  1.00 41.83  ? 255 ASN B CG  1 
ATOM   3978 O OD1 . ASN B 1 255 ? 116.276 127.512 100.441 1.00 41.83  ? 255 ASN B OD1 1 
ATOM   3979 N ND2 . ASN B 1 255 ? 117.428 127.985 98.577  1.00 41.83  ? 255 ASN B ND2 1 
ATOM   3980 N N   . GLN B 1 256 ? 114.416 130.161 102.033 1.00 41.97  ? 256 GLN B N   1 
ATOM   3981 C CA  . GLN B 1 256 ? 114.257 130.087 103.483 1.00 41.97  ? 256 GLN B CA  1 
ATOM   3982 C C   . GLN B 1 256 ? 115.144 129.032 104.135 1.00 41.97  ? 256 GLN B C   1 
ATOM   3983 O O   . GLN B 1 256 ? 114.913 128.673 105.295 1.00 41.97  ? 256 GLN B O   1 
ATOM   3984 C CB  . GLN B 1 256 ? 112.796 129.839 103.886 1.00 41.97  ? 256 GLN B CB  1 
ATOM   3985 C CG  . GLN B 1 256 ? 111.784 130.722 103.178 1.00 41.97  ? 256 GLN B CG  1 
ATOM   3986 C CD  . GLN B 1 256 ? 111.939 132.182 103.528 1.00 41.97  ? 256 GLN B CD  1 
ATOM   3987 O OE1 . GLN B 1 256 ? 112.319 132.525 104.643 1.00 41.97  ? 256 GLN B OE1 1 
ATOM   3988 N NE2 . GLN B 1 256 ? 111.645 133.054 102.571 1.00 41.97  ? 256 GLN B NE2 1 
ATOM   3989 N N   . SER B 1 257 ? 116.149 128.513 103.429 1.00 41.31  ? 257 SER B N   1 
ATOM   3990 C CA  . SER B 1 257 ? 117.068 127.578 104.068 1.00 41.31  ? 257 SER B CA  1 
ATOM   3991 C C   . SER B 1 257 ? 118.027 128.298 105.005 1.00 41.31  ? 257 SER B C   1 
ATOM   3992 O O   . SER B 1 257 ? 118.312 127.811 106.107 1.00 41.31  ? 257 SER B O   1 
ATOM   3993 C CB  . SER B 1 257 ? 117.850 126.796 103.016 1.00 41.31  ? 257 SER B CB  1 
ATOM   3994 O OG  . SER B 1 257 ? 118.853 125.998 103.616 1.00 41.31  ? 257 SER B OG  1 
ATOM   3995 N N   . LEU B 1 258 ? 118.530 129.458 104.580 1.00 41.17  ? 258 LEU B N   1 
ATOM   3996 C CA  . LEU B 1 258 ? 119.468 130.207 105.405 1.00 41.17  ? 258 LEU B CA  1 
ATOM   3997 C C   . LEU B 1 258 ? 118.824 130.631 106.715 1.00 41.17  ? 258 LEU B C   1 
ATOM   3998 O O   . LEU B 1 258 ? 119.435 130.508 107.783 1.00 41.17  ? 258 LEU B O   1 
ATOM   3999 C CB  . LEU B 1 258 ? 119.974 131.429 104.640 1.00 41.17  ? 258 LEU B CB  1 
ATOM   4000 C CG  . LEU B 1 258 ? 121.010 132.312 105.335 1.00 41.17  ? 258 LEU B CG  1 
ATOM   4001 C CD1 . LEU B 1 258 ? 122.077 131.476 106.024 1.00 41.17  ? 258 LEU B CD1 1 
ATOM   4002 C CD2 . LEU B 1 258 ? 121.640 133.281 104.345 1.00 41.17  ? 258 LEU B CD2 1 
ATOM   4003 N N   . THR B 1 259 ? 117.590 131.135 106.652 1.00 41.09  ? 259 THR B N   1 
ATOM   4004 C CA  . THR B 1 259 ? 116.906 131.533 107.875 1.00 41.09  ? 259 THR B CA  1 
ATOM   4005 C C   . THR B 1 259 ? 116.631 130.334 108.769 1.00 41.09  ? 259 THR B C   1 
ATOM   4006 O O   . THR B 1 259 ? 116.767 130.432 109.992 1.00 41.09  ? 259 THR B O   1 
ATOM   4007 C CB  . THR B 1 259 ? 115.614 132.288 107.553 1.00 41.09  ? 259 THR B CB  1 
ATOM   4008 O OG1 . THR B 1 259 ? 115.050 132.808 108.763 1.00 41.09  ? 259 THR B OG1 1 
ATOM   4009 C CG2 . THR B 1 259 ? 114.597 131.403 106.861 1.00 41.09  ? 259 THR B CG2 1 
ATOM   4010 N N   . ILE B 1 260 ? 116.275 129.187 108.184 1.00 41.71  ? 260 ILE B N   1 
ATOM   4011 C CA  . ILE B 1 260 ? 116.035 127.999 108.996 1.00 41.71  ? 260 ILE B CA  1 
ATOM   4012 C C   . ILE B 1 260 ? 117.300 127.606 109.741 1.00 41.71  ? 260 ILE B C   1 
ATOM   4013 O O   . ILE B 1 260 ? 117.278 127.377 110.954 1.00 41.71  ? 260 ILE B O   1 
ATOM   4014 C CB  . ILE B 1 260 ? 115.509 126.841 108.130 1.00 41.71  ? 260 ILE B CB  1 
ATOM   4015 C CG1 . ILE B 1 260 ? 114.007 126.983 107.906 1.00 41.71  ? 260 ILE B CG1 1 
ATOM   4016 C CG2 . ILE B 1 260 ? 115.789 125.510 108.797 1.00 41.71  ? 260 ILE B CG2 1 
ATOM   4017 C CD1 . ILE B 1 260 ? 113.464 126.057 106.847 1.00 41.71  ? 260 ILE B CD1 1 
ATOM   4018 N N   . MET B 1 261 ? 118.432 127.559 109.036 1.00 43.44  ? 261 MET B N   1 
ATOM   4019 C CA  . MET B 1 261 ? 119.671 127.136 109.682 1.00 43.44  ? 261 MET B CA  1 
ATOM   4020 C C   . MET B 1 261 ? 120.116 128.133 110.746 1.00 43.44  ? 261 MET B C   1 
ATOM   4021 O O   . MET B 1 261 ? 120.488 127.742 111.862 1.00 43.44  ? 261 MET B O   1 
ATOM   4022 C CB  . MET B 1 261 ? 120.762 126.930 108.635 1.00 43.44  ? 261 MET B CB  1 
ATOM   4023 C CG  . MET B 1 261 ? 120.634 125.619 107.886 1.00 43.44  ? 261 MET B CG  1 
ATOM   4024 S SD  . MET B 1 261 ? 120.862 124.167 108.931 1.00 43.44  ? 261 MET B SD  1 
ATOM   4025 C CE  . MET B 1 261 ? 122.290 124.641 109.895 1.00 43.44  ? 261 MET B CE  1 
ATOM   4026 N N   . VAL B 1 262 ? 120.097 129.428 110.416 1.00 41.89  ? 262 VAL B N   1 
ATOM   4027 C CA  . VAL B 1 262 ? 120.529 130.441 111.374 1.00 41.89  ? 262 VAL B CA  1 
ATOM   4028 C C   . VAL B 1 262 ? 119.640 130.416 112.609 1.00 41.89  ? 262 VAL B C   1 
ATOM   4029 O O   . VAL B 1 262 ? 120.127 130.426 113.747 1.00 41.89  ? 262 VAL B O   1 
ATOM   4030 C CB  . VAL B 1 262 ? 120.541 131.831 110.716 1.00 41.89  ? 262 VAL B CB  1 
ATOM   4031 C CG1 . VAL B 1 262 ? 120.674 132.908 111.771 1.00 41.89  ? 262 VAL B CG1 1 
ATOM   4032 C CG2 . VAL B 1 262 ? 121.668 131.927 109.706 1.00 41.89  ? 262 VAL B CG2 1 
ATOM   4033 N N   . GLY B 1 263 ? 118.323 130.348 112.404 1.00 40.51  ? 263 GLY B N   1 
ATOM   4034 C CA  . GLY B 1 263 ? 117.409 130.306 113.527 1.00 40.51  ? 263 GLY B CA  1 
ATOM   4035 C C   . GLY B 1 263 ? 117.573 129.065 114.373 1.00 40.51  ? 263 GLY B C   1 
ATOM   4036 O O   . GLY B 1 263 ? 117.498 129.129 115.596 1.00 40.51  ? 263 GLY B O   1 
ATOM   4037 N N   . VAL B 1 264 ? 117.805 127.920 113.735 1.00 41.62  ? 264 VAL B N   1 
ATOM   4038 C CA  . VAL B 1 264 ? 117.934 126.675 114.479 1.00 41.62  ? 264 VAL B CA  1 
ATOM   4039 C C   . VAL B 1 264 ? 119.191 126.692 115.341 1.00 41.62  ? 264 VAL B C   1 
ATOM   4040 O O   . VAL B 1 264 ? 119.148 126.360 116.533 1.00 41.62  ? 264 VAL B O   1 
ATOM   4041 C CB  . VAL B 1 264 ? 117.916 125.475 113.521 1.00 41.62  ? 264 VAL B CB  1 
ATOM   4042 C CG1 . VAL B 1 264 ? 118.408 124.259 114.230 1.00 41.62  ? 264 VAL B CG1 1 
ATOM   4043 C CG2 . VAL B 1 264 ? 116.506 125.230 113.025 1.00 41.62  ? 264 VAL B CG2 1 
ATOM   4044 N N   . ASN B 1 265 ? 120.331 127.078 114.758 1.00 44.82  ? 265 ASN B N   1 
ATOM   4045 C CA  . ASN B 1 265 ? 121.555 127.125 115.554 1.00 44.82  ? 265 ASN B CA  1 
ATOM   4046 C C   . ASN B 1 265 ? 121.466 128.175 116.654 1.00 44.82  ? 265 ASN B C   1 
ATOM   4047 O O   . ASN B 1 265 ? 121.891 127.927 117.792 1.00 44.82  ? 265 ASN B O   1 
ATOM   4048 C CB  . ASN B 1 265 ? 122.761 127.397 114.658 1.00 44.82  ? 265 ASN B CB  1 
ATOM   4049 C CG  . ASN B 1 265 ? 123.004 126.292 113.657 1.00 44.82  ? 265 ASN B CG  1 
ATOM   4050 O OD1 . ASN B 1 265 ? 123.327 125.165 114.026 1.00 44.82  ? 265 ASN B OD1 1 
ATOM   4051 N ND2 . ASN B 1 265 ? 122.848 126.609 112.378 1.00 44.82  ? 265 ASN B ND2 1 
ATOM   4052 N N   . LEU B 1 266 ? 120.898 129.345 116.346 1.00 41.21  ? 266 LEU B N   1 
ATOM   4053 C CA  . LEU B 1 266 ? 120.737 130.372 117.367 1.00 41.21  ? 266 LEU B CA  1 
ATOM   4054 C C   . LEU B 1 266 ? 119.816 129.895 118.478 1.00 41.21  ? 266 LEU B C   1 
ATOM   4055 O O   . LEU B 1 266 ? 120.074 130.149 119.658 1.00 41.21  ? 266 LEU B O   1 
ATOM   4056 C CB  . LEU B 1 266 ? 120.204 131.657 116.739 1.00 41.21  ? 266 LEU B CB  1 
ATOM   4057 C CG  . LEU B 1 266 ? 121.249 132.659 116.251 1.00 41.21  ? 266 LEU B CG  1 
ATOM   4058 C CD1 . LEU B 1 266 ? 120.585 133.945 115.796 1.00 41.21  ? 266 LEU B CD1 1 
ATOM   4059 C CD2 . LEU B 1 266 ? 122.267 132.936 117.339 1.00 41.21  ? 266 LEU B CD2 1 
ATOM   4060 N N   . LEU B 1 267 ? 118.742 129.192 118.119 1.00 40.92  ? 267 LEU B N   1 
ATOM   4061 C CA  . LEU B 1 267 ? 117.805 128.685 119.110 1.00 40.92  ? 267 LEU B CA  1 
ATOM   4062 C C   . LEU B 1 267 ? 118.458 127.647 120.006 1.00 40.92  ? 267 LEU B C   1 
ATOM   4063 O O   . LEU B 1 267 ? 118.260 127.667 121.222 1.00 40.92  ? 267 LEU B O   1 
ATOM   4064 C CB  . LEU B 1 267 ? 116.579 128.104 118.410 1.00 40.92  ? 267 LEU B CB  1 
ATOM   4065 C CG  . LEU B 1 267 ? 115.425 127.603 119.272 1.00 40.92  ? 267 LEU B CG  1 
ATOM   4066 C CD1 . LEU B 1 267 ? 114.838 128.740 120.076 1.00 40.92  ? 267 LEU B CD1 1 
ATOM   4067 C CD2 . LEU B 1 267 ? 114.357 126.960 118.404 1.00 40.92  ? 267 LEU B CD2 1 
ATOM   4068 N N   . VAL B 1 268 ? 119.253 126.742 119.433 1.00 40.08  ? 268 VAL B N   1 
ATOM   4069 C CA  . VAL B 1 268 ? 119.915 125.725 120.249 1.00 40.08  ? 268 VAL B CA  1 
ATOM   4070 C C   . VAL B 1 268 ? 120.905 126.374 121.209 1.00 40.08  ? 268 VAL B C   1 
ATOM   4071 O O   . VAL B 1 268 ? 120.916 126.080 122.414 1.00 40.08  ? 268 VAL B O   1 
ATOM   4072 C CB  . VAL B 1 268 ? 120.597 124.676 119.355 1.00 40.08  ? 268 VAL B CB  1 
ATOM   4073 C CG1 . VAL B 1 268 ? 121.397 123.706 120.198 1.00 40.08  ? 268 VAL B CG1 1 
ATOM   4074 C CG2 . VAL B 1 268 ? 119.558 123.930 118.543 1.00 40.08  ? 268 VAL B CG2 1 
ATOM   4075 N N   . LEU B 1 269 ? 121.737 127.286 120.695 1.00 40.40  ? 269 LEU B N   1 
ATOM   4076 C CA  . LEU B 1 269 ? 122.721 127.952 121.544 1.00 40.40  ? 269 LEU B CA  1 
ATOM   4077 C C   . LEU B 1 269 ? 122.041 128.748 122.651 1.00 40.40  ? 269 LEU B C   1 
ATOM   4078 O O   . LEU B 1 269 ? 122.414 128.646 123.827 1.00 40.40  ? 269 LEU B O   1 
ATOM   4079 C CB  . LEU B 1 269 ? 123.613 128.861 120.700 1.00 40.40  ? 269 LEU B CB  1 
ATOM   4080 C CG  . LEU B 1 269 ? 124.763 128.196 119.946 1.00 40.40  ? 269 LEU B CG  1 
ATOM   4081 C CD1 . LEU B 1 269 ? 125.476 129.210 119.067 1.00 40.40  ? 269 LEU B CD1 1 
ATOM   4082 C CD2 . LEU B 1 269 ? 125.736 127.541 120.915 1.00 40.40  ? 269 LEU B CD2 1 
ATOM   4083 N N   . ALA B 1 270 ? 121.030 129.543 122.291 1.00 38.44  ? 270 ALA B N   1 
ATOM   4084 C CA  . ALA B 1 270 ? 120.335 130.364 123.271 1.00 38.44  ? 270 ALA B CA  1 
ATOM   4085 C C   . ALA B 1 270 ? 119.615 129.506 124.298 1.00 38.44  ? 270 ALA B C   1 
ATOM   4086 O O   . ALA B 1 270 ? 119.636 129.816 125.491 1.00 38.44  ? 270 ALA B O   1 
ATOM   4087 C CB  . ALA B 1 270 ? 119.353 131.299 122.570 1.00 38.44  ? 270 ALA B CB  1 
ATOM   4088 N N   . ALA B 1 271 ? 118.972 128.424 123.860 1.00 39.15  ? 271 ALA B N   1 
ATOM   4089 C CA  . ALA B 1 271 ? 118.258 127.559 124.788 1.00 39.15  ? 271 ALA B CA  1 
ATOM   4090 C C   . ALA B 1 271 ? 119.211 126.942 125.799 1.00 39.15  ? 271 ALA B C   1 
ATOM   4091 O O   . ALA B 1 271 ? 118.952 126.970 127.007 1.00 39.15  ? 271 ALA B O   1 
ATOM   4092 C CB  . ALA B 1 271 ? 117.506 126.477 124.015 1.00 39.15  ? 271 ALA B CB  1 
ATOM   4093 N N   . GLY B 1 272 ? 120.336 126.401 125.327 1.00 38.45  ? 272 GLY B N   1 
ATOM   4094 C CA  . GLY B 1 272 ? 121.301 125.824 126.253 1.00 38.45  ? 272 GLY B CA  1 
ATOM   4095 C C   . GLY B 1 272 ? 121.862 126.850 127.220 1.00 38.45  ? 272 GLY B C   1 
ATOM   4096 O O   . GLY B 1 272 ? 121.945 126.608 128.432 1.00 38.45  ? 272 GLY B O   1 
ATOM   4097 N N   . LEU B 1 273 ? 122.244 128.018 126.698 1.00 40.30  ? 273 LEU B N   1 
ATOM   4098 C CA  . LEU B 1 273 ? 122.837 129.056 127.535 1.00 40.30  ? 273 LEU B CA  1 
ATOM   4099 C C   . LEU B 1 273 ? 121.848 129.535 128.589 1.00 40.30  ? 273 LEU B C   1 
ATOM   4100 O O   . LEU B 1 273 ? 122.198 129.678 129.769 1.00 40.30  ? 273 LEU B O   1 
ATOM   4101 C CB  . LEU B 1 273 ? 123.320 130.211 126.655 1.00 40.30  ? 273 LEU B CB  1 
ATOM   4102 C CG  . LEU B 1 273 ? 124.274 131.291 127.177 1.00 40.30  ? 273 LEU B CG  1 
ATOM   4103 C CD1 . LEU B 1 273 ? 124.755 132.133 126.008 1.00 40.30  ? 273 LEU B CD1 1 
ATOM   4104 C CD2 . LEU B 1 273 ? 123.644 132.193 128.223 1.00 40.30  ? 273 LEU B CD2 1 
ATOM   4105 N N   . LEU B 1 274 ? 120.597 129.771 128.187 1.00 41.16  ? 274 LEU B N   1 
ATOM   4106 C CA  . LEU B 1 274 ? 119.610 130.283 129.126 1.00 41.16  ? 274 LEU B CA  1 
ATOM   4107 C C   . LEU B 1 274 ? 119.234 129.222 130.146 1.00 41.16  ? 274 LEU B C   1 
ATOM   4108 O O   . LEU B 1 274 ? 119.017 129.540 131.320 1.00 41.16  ? 274 LEU B O   1 
ATOM   4109 C CB  . LEU B 1 274 ? 118.381 130.789 128.374 1.00 41.16  ? 274 LEU B CB  1 
ATOM   4110 C CG  . LEU B 1 274 ? 118.653 131.974 127.444 1.00 41.16  ? 274 LEU B CG  1 
ATOM   4111 C CD1 . LEU B 1 274 ? 117.356 132.566 126.921 1.00 41.16  ? 274 LEU B CD1 1 
ATOM   4112 C CD2 . LEU B 1 274 ? 119.494 133.029 128.138 1.00 41.16  ? 274 LEU B CD2 1 
ATOM   4113 N N   . PHE B 1 275 ? 119.194 127.954 129.735 1.00 42.28  ? 275 PHE B N   1 
ATOM   4114 C CA  . PHE B 1 275 ? 118.981 126.876 130.692 1.00 42.28  ? 275 PHE B CA  1 
ATOM   4115 C C   . PHE B 1 275 ? 120.060 126.870 131.766 1.00 42.28  ? 275 PHE B C   1 
ATOM   4116 O O   . PHE B 1 275 ? 119.758 126.865 132.968 1.00 42.28  ? 275 PHE B O   1 
ATOM   4117 C CB  . PHE B 1 275 ? 118.959 125.539 129.954 1.00 42.28  ? 275 PHE B CB  1 
ATOM   4118 C CG  . PHE B 1 275 ? 118.719 124.357 130.843 1.00 42.28  ? 275 PHE B CG  1 
ATOM   4119 C CD1 . PHE B 1 275 ? 117.459 124.076 131.335 1.00 42.28  ? 275 PHE B CD1 1 
ATOM   4120 C CD2 . PHE B 1 275 ? 119.767 123.518 131.182 1.00 42.28  ? 275 PHE B CD2 1 
ATOM   4121 C CE1 . PHE B 1 275 ? 117.255 122.982 132.153 1.00 42.28  ? 275 PHE B CE1 1 
ATOM   4122 C CE2 . PHE B 1 275 ? 119.565 122.431 131.998 1.00 42.28  ? 275 PHE B CE2 1 
ATOM   4123 C CZ  . PHE B 1 275 ? 118.310 122.157 132.481 1.00 42.28  ? 275 PHE B CZ  1 
ATOM   4124 N N   . VAL B 1 276 ? 121.330 126.894 131.352 1.00 40.50  ? 276 VAL B N   1 
ATOM   4125 C CA  . VAL B 1 276 ? 122.411 126.847 132.335 1.00 40.50  ? 276 VAL B CA  1 
ATOM   4126 C C   . VAL B 1 276 ? 122.378 128.063 133.254 1.00 40.50  ? 276 VAL B C   1 
ATOM   4127 O O   . VAL B 1 276 ? 122.538 127.934 134.475 1.00 40.50  ? 276 VAL B O   1 
ATOM   4128 C CB  . VAL B 1 276 ? 123.771 126.712 131.630 1.00 40.50  ? 276 VAL B CB  1 
ATOM   4129 C CG1 . VAL B 1 276 ? 124.894 126.748 132.645 1.00 40.50  ? 276 VAL B CG1 1 
ATOM   4130 C CG2 . VAL B 1 276 ? 123.820 125.429 130.834 1.00 40.50  ? 276 VAL B CG2 1 
ATOM   4131 N N   . VAL B 1 277 ? 122.169 129.259 132.696 1.00 41.88  ? 277 VAL B N   1 
ATOM   4132 C CA  . VAL B 1 277 ? 122.206 130.459 133.531 1.00 41.88  ? 277 VAL B CA  1 
ATOM   4133 C C   . VAL B 1 277 ? 121.040 130.476 134.515 1.00 41.88  ? 277 VAL B C   1 
ATOM   4134 O O   . VAL B 1 277 ? 121.219 130.770 135.701 1.00 41.88  ? 277 VAL B O   1 
ATOM   4135 C CB  . VAL B 1 277 ? 122.275 131.742 132.681 1.00 41.88  ? 277 VAL B CB  1 
ATOM   4136 C CG1 . VAL B 1 277 ? 123.544 131.742 131.843 1.00 41.88  ? 277 VAL B CG1 1 
ATOM   4137 C CG2 . VAL B 1 277 ? 121.050 131.923 131.816 1.00 41.88  ? 277 VAL B CG2 1 
ATOM   4138 N N   . THR B 1 278 ? 119.827 130.164 134.046 1.00 42.52  ? 278 THR B N   1 
ATOM   4139 C CA  . THR B 1 278 ? 118.677 130.183 134.941 1.00 42.52  ? 278 THR B CA  1 
ATOM   4140 C C   . THR B 1 278 ? 118.707 129.044 135.947 1.00 42.52  ? 278 THR B C   1 
ATOM   4141 O O   . THR B 1 278 ? 118.010 129.121 136.964 1.00 42.52  ? 278 THR B O   1 
ATOM   4142 C CB  . THR B 1 278 ? 117.372 130.128 134.148 1.00 42.52  ? 278 THR B CB  1 
ATOM   4143 O OG1 . THR B 1 278 ? 116.281 130.474 135.008 1.00 42.52  ? 278 THR B OG1 1 
ATOM   4144 C CG2 . THR B 1 278 ? 117.134 128.731 133.615 1.00 42.52  ? 278 THR B CG2 1 
ATOM   4145 N N   . ARG B 1 279 ? 119.492 127.992 135.701 1.00 42.30  ? 279 ARG B N   1 
ATOM   4146 C CA  . ARG B 1 279 ? 119.620 126.947 136.710 1.00 42.30  ? 279 ARG B CA  1 
ATOM   4147 C C   . ARG B 1 279 ? 120.683 127.288 137.747 1.00 42.30  ? 279 ARG B C   1 
ATOM   4148 O O   . ARG B 1 279 ? 120.394 127.354 138.946 1.00 42.30  ? 279 ARG B O   1 
ATOM   4149 C CB  . ARG B 1 279 ? 119.927 125.605 136.046 1.00 42.30  ? 279 ARG B CB  1 
ATOM   4150 C CG  . ARG B 1 279 ? 119.978 124.452 137.026 1.00 42.30  ? 279 ARG B CG  1 
ATOM   4151 C CD  . ARG B 1 279 ? 120.060 123.123 136.312 1.00 42.30  ? 279 ARG B CD  1 
ATOM   4152 N NE  . ARG B 1 279 ? 118.813 122.810 135.626 1.00 42.30  ? 279 ARG B NE  1 
ATOM   4153 C CZ  . ARG B 1 279 ? 117.969 121.861 136.003 1.00 42.30  ? 279 ARG B CZ  1 
ATOM   4154 N NH1 . ARG B 1 279 ? 118.205 121.109 137.065 1.00 42.30  ? 279 ARG B NH1 1 
ATOM   4155 N NH2 . ARG B 1 279 ? 116.857 121.665 135.302 1.00 42.30  ? 279 ARG B NH2 1 
ATOM   4156 N N   . TYR B 1 280 ? 121.920 127.512 137.310 1.00 42.84  ? 280 TYR B N   1 
ATOM   4157 C CA  . TYR B 1 280 ? 123.039 127.618 138.238 1.00 42.84  ? 280 TYR B CA  1 
ATOM   4158 C C   . TYR B 1 280 ? 123.310 129.038 138.710 1.00 42.84  ? 280 TYR B C   1 
ATOM   4159 O O   . TYR B 1 280 ? 124.269 129.249 139.457 1.00 42.84  ? 280 TYR B O   1 
ATOM   4160 C CB  . TYR B 1 280 ? 124.307 127.045 137.604 1.00 42.84  ? 280 TYR B CB  1 
ATOM   4161 C CG  . TYR B 1 280 ? 124.357 125.540 137.640 1.00 42.84  ? 280 TYR B CG  1 
ATOM   4162 C CD1 . TYR B 1 280 ? 124.620 124.866 138.821 1.00 42.84  ? 280 TYR B CD1 1 
ATOM   4163 C CD2 . TYR B 1 280 ? 124.129 124.793 136.499 1.00 42.84  ? 280 TYR B CD2 1 
ATOM   4164 C CE1 . TYR B 1 280 ? 124.660 123.494 138.862 1.00 42.84  ? 280 TYR B CE1 1 
ATOM   4165 C CE2 . TYR B 1 280 ? 124.169 123.424 136.531 1.00 42.84  ? 280 TYR B CE2 1 
ATOM   4166 C CZ  . TYR B 1 280 ? 124.433 122.776 137.714 1.00 42.84  ? 280 TYR B CZ  1 
ATOM   4167 O OH  . TYR B 1 280 ? 124.474 121.401 137.750 1.00 42.84  ? 280 TYR B OH  1 
ATOM   4168 N N   . LEU B 1 281 ? 122.499 130.013 138.307 1.00 47.31  ? 281 LEU B N   1 
ATOM   4169 C CA  . LEU B 1 281 ? 122.701 131.400 138.707 1.00 47.31  ? 281 LEU B CA  1 
ATOM   4170 C C   . LEU B 1 281 ? 121.399 132.028 139.181 1.00 47.31  ? 281 LEU B C   1 
ATOM   4171 O O   . LEU B 1 281 ? 121.062 133.156 138.817 1.00 47.31  ? 281 LEU B O   1 
ATOM   4172 C CB  . LEU B 1 281 ? 123.312 132.212 137.571 1.00 47.31  ? 281 LEU B CB  1 
ATOM   4173 C CG  . LEU B 1 281 ? 124.812 132.002 137.381 1.00 47.31  ? 281 LEU B CG  1 
ATOM   4174 C CD1 . LEU B 1 281 ? 125.315 132.782 136.184 1.00 47.31  ? 281 LEU B CD1 1 
ATOM   4175 C CD2 . LEU B 1 281 ? 125.569 132.392 138.637 1.00 47.31  ? 281 LEU B CD2 1 
ATOM   4176 N N   . HIS B 1 282 ? 120.646 131.304 140.010 1.00 54.24  ? 282 HIS B N   1 
ATOM   4177 C CA  . HIS B 1 282 ? 119.441 131.866 140.605 1.00 54.24  ? 282 HIS B CA  1 
ATOM   4178 C C   . HIS B 1 282 ? 119.748 132.958 141.619 1.00 54.24  ? 282 HIS B C   1 
ATOM   4179 O O   . HIS B 1 282 ? 118.836 133.700 141.999 1.00 54.24  ? 282 HIS B O   1 
ATOM   4180 C CB  . HIS B 1 282 ? 118.616 130.762 141.268 1.00 54.24  ? 282 HIS B CB  1 
ATOM   4181 C CG  . HIS B 1 282 ? 119.368 129.983 142.302 1.00 54.24  ? 282 HIS B CG  1 
ATOM   4182 N ND1 . HIS B 1 282 ? 120.220 128.949 141.981 1.00 54.24  ? 282 HIS B ND1 1 
ATOM   4183 C CD2 . HIS B 1 282 ? 119.393 130.086 143.652 1.00 54.24  ? 282 HIS B CD2 1 
ATOM   4184 C CE1 . HIS B 1 282 ? 120.740 128.449 143.088 1.00 54.24  ? 282 HIS B CE1 1 
ATOM   4185 N NE2 . HIS B 1 282 ? 120.254 129.121 144.116 1.00 54.24  ? 282 HIS B NE2 1 
ATOM   4186 N N   . SER B 1 283 ? 120.997 133.070 142.064 1.00 54.20  ? 283 SER B N   1 
ATOM   4187 C CA  . SER B 1 283 ? 121.425 134.133 142.961 1.00 54.20  ? 283 SER B CA  1 
ATOM   4188 C C   . SER B 1 283 ? 121.925 135.360 142.212 1.00 54.20  ? 283 SER B C   1 
ATOM   4189 O O   . SER B 1 283 ? 122.414 136.301 142.844 1.00 54.20  ? 283 SER B O   1 
ATOM   4190 C CB  . SER B 1 283 ? 122.513 133.620 143.905 1.00 54.20  ? 283 SER B CB  1 
ATOM   4191 O OG  . SER B 1 283 ? 123.167 134.695 144.557 1.00 54.20  ? 283 SER B OG  1 
ATOM   4192 N N   . TRP B 1 284 ? 121.815 135.370 140.885 1.00 52.49  ? 284 TRP B N   1 
ATOM   4193 C CA  . TRP B 1 284 ? 122.214 136.503 140.052 1.00 52.49  ? 284 TRP B CA  1 
ATOM   4194 C C   . TRP B 1 284 ? 121.019 136.899 139.196 1.00 52.49  ? 284 TRP B C   1 
ATOM   4195 O O   . TRP B 1 284 ? 120.998 136.656 137.984 1.00 52.49  ? 284 TRP B O   1 
ATOM   4196 C CB  . TRP B 1 284 ? 123.419 136.151 139.180 1.00 52.49  ? 284 TRP B CB  1 
ATOM   4197 C CG  . TRP B 1 284 ? 124.687 135.925 139.941 1.00 52.49  ? 284 TRP B CG  1 
ATOM   4198 C CD1 . TRP B 1 284 ? 124.899 135.003 140.922 1.00 52.49  ? 284 TRP B CD1 1 
ATOM   4199 C CD2 . TRP B 1 284 ? 125.926 136.622 139.772 1.00 52.49  ? 284 TRP B CD2 1 
ATOM   4200 N NE1 . TRP B 1 284 ? 126.190 135.088 141.381 1.00 52.49  ? 284 TRP B NE1 1 
ATOM   4201 C CE2 . TRP B 1 284 ? 126.841 136.075 140.690 1.00 52.49  ? 284 TRP B CE2 1 
ATOM   4202 C CE3 . TRP B 1 284 ? 126.348 137.659 138.937 1.00 52.49  ? 284 TRP B CE3 1 
ATOM   4203 C CZ2 . TRP B 1 284 ? 128.153 136.530 140.797 1.00 52.49  ? 284 TRP B CZ2 1 
ATOM   4204 C CZ3 . TRP B 1 284 ? 127.649 138.109 139.043 1.00 52.49  ? 284 TRP B CZ3 1 
ATOM   4205 C CH2 . TRP B 1 284 ? 128.537 137.545 139.966 1.00 52.49  ? 284 TRP B CH2 1 
ATOM   4206 N N   . PRO B 1 285 ? 119.996 137.507 139.806 1.00 51.68  ? 285 PRO B N   1 
ATOM   4207 C CA  . PRO B 1 285 ? 118.754 137.778 139.059 1.00 51.68  ? 285 PRO B CA  1 
ATOM   4208 C C   . PRO B 1 285 ? 118.941 138.685 137.858 1.00 51.68  ? 285 PRO B C   1 
ATOM   4209 O O   . PRO B 1 285 ? 118.341 138.445 136.799 1.00 51.68  ? 285 PRO B O   1 
ATOM   4210 C CB  . PRO B 1 285 ? 117.852 138.420 140.121 1.00 51.68  ? 285 PRO B CB  1 
ATOM   4211 C CG  . PRO B 1 285 ? 118.796 138.985 141.125 1.00 51.68  ? 285 PRO B CG  1 
ATOM   4212 C CD  . PRO B 1 285 ? 119.942 138.035 141.179 1.00 51.68  ? 285 PRO B CD  1 
ATOM   4213 N N   . ASN B 1 286 ? 119.768 139.722 137.992 1.00 52.92  ? 286 ASN B N   1 
ATOM   4214 C CA  . ASN B 1 286 ? 119.961 140.658 136.891 1.00 52.92  ? 286 ASN B CA  1 
ATOM   4215 C C   . ASN B 1 286 ? 120.604 139.976 135.694 1.00 52.92  ? 286 ASN B C   1 
ATOM   4216 O O   . ASN B 1 286 ? 120.200 140.206 134.548 1.00 52.92  ? 286 ASN B O   1 
ATOM   4217 C CB  . ASN B 1 286 ? 120.808 141.838 137.356 1.00 52.92  ? 286 ASN B CB  1 
ATOM   4218 C CG  . ASN B 1 286 ? 119.970 143.014 137.800 1.00 52.92  ? 286 ASN B CG  1 
ATOM   4219 O OD1 . ASN B 1 286 ? 119.253 143.615 137.002 1.00 52.92  ? 286 ASN B OD1 1 
ATOM   4220 N ND2 . ASN B 1 286 ? 120.053 143.348 139.080 1.00 52.92  ? 286 ASN B ND2 1 
ATOM   4221 N N   . LEU B 1 287 ? 121.603 139.125 135.940 1.00 50.79  ? 287 LEU B N   1 
ATOM   4222 C CA  . LEU B 1 287 ? 122.260 138.426 134.843 1.00 50.79  ? 287 LEU B CA  1 
ATOM   4223 C C   . LEU B 1 287 ? 121.289 137.509 134.115 1.00 50.79  ? 287 LEU B C   1 
ATOM   4224 O O   . LEU B 1 287 ? 121.259 137.483 132.880 1.00 50.79  ? 287 LEU B O   1 
ATOM   4225 C CB  . LEU B 1 287 ? 123.455 137.634 135.368 1.00 50.79  ? 287 LEU B CB  1 
ATOM   4226 C CG  . LEU B 1 287 ? 124.242 136.824 134.338 1.00 50.79  ? 287 LEU B CG  1 
ATOM   4227 C CD1 . LEU B 1 287 ? 124.625 137.694 133.155 1.00 50.79  ? 287 LEU B CD1 1 
ATOM   4228 C CD2 . LEU B 1 287 ? 125.476 136.223 134.975 1.00 50.79  ? 287 LEU B CD2 1 
ATOM   4229 N N   . VAL B 1 288 ? 120.483 136.755 134.862 1.00 48.13  ? 288 VAL B N   1 
ATOM   4230 C CA  . VAL B 1 288 ? 119.536 135.836 134.238 1.00 48.13  ? 288 VAL B CA  1 
ATOM   4231 C C   . VAL B 1 288 ? 118.518 136.605 133.410 1.00 48.13  ? 288 VAL B C   1 
ATOM   4232 O O   . VAL B 1 288 ? 118.212 136.234 132.270 1.00 48.13  ? 288 VAL B O   1 
ATOM   4233 C CB  . VAL B 1 288 ? 118.853 134.960 135.302 1.00 48.13  ? 288 VAL B CB  1 
ATOM   4234 C CG1 . VAL B 1 288 ? 117.793 134.080 134.663 1.00 48.13  ? 288 VAL B CG1 1 
ATOM   4235 C CG2 . VAL B 1 288 ? 119.883 134.111 136.019 1.00 48.13  ? 288 VAL B CG2 1 
ATOM   4236 N N   . PHE B 1 289 ? 117.978 137.691 133.969 1.00 47.65  ? 289 PHE B N   1 
ATOM   4237 C CA  . PHE B 1 289 ? 116.974 138.462 133.243 1.00 47.65  ? 289 PHE B CA  1 
ATOM   4238 C C   . PHE B 1 289 ? 117.562 139.063 131.973 1.00 47.65  ? 289 PHE B C   1 
ATOM   4239 O O   . PHE B 1 289 ? 116.968 138.962 130.890 1.00 47.65  ? 289 PHE B O   1 
ATOM   4240 C CB  . PHE B 1 289 ? 116.397 139.553 134.144 1.00 47.65  ? 289 PHE B CB  1 
ATOM   4241 C CG  . PHE B 1 289 ? 115.609 140.597 133.406 1.00 47.65  ? 289 PHE B CG  1 
ATOM   4242 C CD1 . PHE B 1 289 ? 114.604 140.237 132.528 1.00 47.65  ? 289 PHE B CD1 1 
ATOM   4243 C CD2 . PHE B 1 289 ? 115.870 141.940 133.598 1.00 47.65  ? 289 PHE B CD2 1 
ATOM   4244 C CE1 . PHE B 1 289 ? 113.886 141.197 131.852 1.00 47.65  ? 289 PHE B CE1 1 
ATOM   4245 C CE2 . PHE B 1 289 ? 115.154 142.899 132.927 1.00 47.65  ? 289 PHE B CE2 1 
ATOM   4246 C CZ  . PHE B 1 289 ? 114.159 142.529 132.056 1.00 47.65  ? 289 PHE B CZ  1 
ATOM   4247 N N   . GLY B 1 290 ? 118.739 139.681 132.085 1.00 45.65  ? 290 GLY B N   1 
ATOM   4248 C CA  . GLY B 1 290 ? 119.360 140.274 130.916 1.00 45.65  ? 290 GLY B CA  1 
ATOM   4249 C C   . GLY B 1 290 ? 119.679 139.251 129.847 1.00 45.65  ? 290 GLY B C   1 
ATOM   4250 O O   . GLY B 1 290 ? 119.430 139.482 128.664 1.00 45.65  ? 290 GLY B O   1 
ATOM   4251 N N   . LEU B 1 291 ? 120.216 138.096 130.250 1.00 45.28  ? 291 LEU B N   1 
ATOM   4252 C CA  . LEU B 1 291 ? 120.574 137.070 129.279 1.00 45.28  ? 291 LEU B CA  1 
ATOM   4253 C C   . LEU B 1 291 ? 119.342 136.487 128.601 1.00 45.28  ? 291 LEU B C   1 
ATOM   4254 O O   . LEU B 1 291 ? 119.353 136.252 127.388 1.00 45.28  ? 291 LEU B O   1 
ATOM   4255 C CB  . LEU B 1 291 ? 121.392 135.973 129.956 1.00 45.28  ? 291 LEU B CB  1 
ATOM   4256 C CG  . LEU B 1 291 ? 122.872 136.309 130.147 1.00 45.28  ? 291 LEU B CG  1 
ATOM   4257 C CD1 . LEU B 1 291 ? 123.648 135.093 130.605 1.00 45.28  ? 291 LEU B CD1 1 
ATOM   4258 C CD2 . LEU B 1 291 ? 123.467 136.868 128.868 1.00 45.28  ? 291 LEU B CD2 1 
ATOM   4259 N N   . THR B 1 292 ? 118.269 136.246 129.359 1.00 44.18  ? 292 THR B N   1 
ATOM   4260 C CA  . THR B 1 292 ? 117.059 135.697 128.756 1.00 44.18  ? 292 THR B CA  1 
ATOM   4261 C C   . THR B 1 292 ? 116.444 136.681 127.771 1.00 44.18  ? 292 THR B C   1 
ATOM   4262 O O   . THR B 1 292 ? 116.069 136.306 126.649 1.00 44.18  ? 292 THR B O   1 
ATOM   4263 C CB  . THR B 1 292 ? 116.050 135.329 129.842 1.00 44.18  ? 292 THR B CB  1 
ATOM   4264 O OG1 . THR B 1 292 ? 116.718 134.638 130.903 1.00 44.18  ? 292 THR B OG1 1 
ATOM   4265 C CG2 . THR B 1 292 ? 114.964 134.437 129.270 1.00 44.18  ? 292 THR B CG2 1 
ATOM   4266 N N   . SER B 1 293 ? 116.345 137.953 128.169 1.00 45.21  ? 293 SER B N   1 
ATOM   4267 C CA  . SER B 1 293 ? 115.814 138.957 127.258 1.00 45.21  ? 293 SER B CA  1 
ATOM   4268 C C   . SER B 1 293 ? 116.682 139.094 126.018 1.00 45.21  ? 293 SER B C   1 
ATOM   4269 O O   . SER B 1 293 ? 116.165 139.193 124.901 1.00 45.21  ? 293 SER B O   1 
ATOM   4270 C CB  . SER B 1 293 ? 115.689 140.303 127.956 1.00 45.21  ? 293 SER B CB  1 
ATOM   4271 O OG  . SER B 1 293 ? 115.267 141.276 127.021 1.00 45.21  ? 293 SER B OG  1 
ATOM   4272 N N   . GLY B 1 294 ? 118.005 139.099 126.193 1.00 45.26  ? 294 GLY B N   1 
ATOM   4273 C CA  . GLY B 1 294 ? 118.889 139.200 125.047 1.00 45.26  ? 294 GLY B CA  1 
ATOM   4274 C C   . GLY B 1 294 ? 118.756 138.026 124.100 1.00 45.26  ? 294 GLY B C   1 
ATOM   4275 O O   . GLY B 1 294 ? 118.712 138.205 122.884 1.00 45.26  ? 294 GLY B O   1 
ATOM   4276 N N   . GLY B 1 295 ? 118.665 136.813 124.642 1.00 44.63  ? 295 GLY B N   1 
ATOM   4277 C CA  . GLY B 1 295 ? 118.531 135.650 123.782 1.00 44.63  ? 295 GLY B CA  1 
ATOM   4278 C C   . GLY B 1 295 ? 117.237 135.660 122.996 1.00 44.63  ? 295 GLY B C   1 
ATOM   4279 O O   . GLY B 1 295 ? 117.226 135.410 121.786 1.00 44.63  ? 295 GLY B O   1 
ATOM   4280 N N   . ILE B 1 296 ? 116.126 135.961 123.671 1.00 44.30  ? 296 ILE B N   1 
ATOM   4281 C CA  . ILE B 1 296 ? 114.838 136.026 122.982 1.00 44.30  ? 296 ILE B CA  1 
ATOM   4282 C C   . ILE B 1 296 ? 114.849 137.122 121.924 1.00 44.30  ? 296 ILE B C   1 
ATOM   4283 O O   . ILE B 1 296 ? 114.399 136.917 120.789 1.00 44.30  ? 296 ILE B O   1 
ATOM   4284 C CB  . ILE B 1 296 ? 113.702 136.227 123.995 1.00 44.30  ? 296 ILE B CB  1 
ATOM   4285 C CG1 . ILE B 1 296 ? 113.474 134.934 124.764 1.00 44.30  ? 296 ILE B CG1 1 
ATOM   4286 C CG2 . ILE B 1 296 ? 112.434 136.673 123.299 1.00 44.30  ? 296 ILE B CG2 1 
ATOM   4287 C CD1 . ILE B 1 296 ? 112.657 135.126 125.967 1.00 44.30  ? 296 ILE B CD1 1 
ATOM   4288 N N   . PHE B 1 297 ? 115.369 138.299 122.278 1.00 45.35  ? 297 PHE B N   1 
ATOM   4289 C CA  . PHE B 1 297 ? 115.413 139.415 121.342 1.00 45.35  ? 297 PHE B CA  1 
ATOM   4290 C C   . PHE B 1 297 ? 116.234 139.045 120.113 1.00 45.35  ? 297 PHE B C   1 
ATOM   4291 O O   . PHE B 1 297 ? 115.781 139.222 118.976 1.00 45.35  ? 297 PHE B O   1 
ATOM   4292 C CB  . PHE B 1 297 ? 115.996 140.635 122.061 1.00 45.35  ? 297 PHE B CB  1 
ATOM   4293 C CG  . PHE B 1 297 ? 116.292 141.815 121.172 1.00 45.35  ? 297 PHE B CG  1 
ATOM   4294 C CD1 . PHE B 1 297 ? 115.546 142.076 120.037 1.00 45.35  ? 297 PHE B CD1 1 
ATOM   4295 C CD2 . PHE B 1 297 ? 117.335 142.670 121.487 1.00 45.35  ? 297 PHE B CD2 1 
ATOM   4296 C CE1 . PHE B 1 297 ? 115.833 143.168 119.240 1.00 45.35  ? 297 PHE B CE1 1 
ATOM   4297 C CE2 . PHE B 1 297 ? 117.626 143.758 120.691 1.00 45.35  ? 297 PHE B CE2 1 
ATOM   4298 C CZ  . PHE B 1 297 ? 116.875 144.006 119.565 1.00 45.35  ? 297 PHE B CZ  1 
ATOM   4299 N N   . VAL B 1 298 ? 117.426 138.480 120.323 1.00 44.56  ? 298 VAL B N   1 
ATOM   4300 C CA  . VAL B 1 298 ? 118.299 138.141 119.202 1.00 44.56  ? 298 VAL B CA  1 
ATOM   4301 C C   . VAL B 1 298 ? 117.648 137.092 118.315 1.00 44.56  ? 298 VAL B C   1 
ATOM   4302 O O   . VAL B 1 298 ? 117.592 137.247 117.092 1.00 44.56  ? 298 VAL B O   1 
ATOM   4303 C CB  . VAL B 1 298 ? 119.678 137.679 119.704 1.00 44.56  ? 298 VAL B CB  1 
ATOM   4304 C CG1 . VAL B 1 298 ? 120.528 137.224 118.536 1.00 44.56  ? 298 VAL B CG1 1 
ATOM   4305 C CG2 . VAL B 1 298 ? 120.384 138.819 120.410 1.00 44.56  ? 298 VAL B CG2 1 
ATOM   4306 N N   . CYS B 1 299 ? 117.127 136.018 118.913 1.00 44.01  ? 299 CYS B N   1 
ATOM   4307 C CA  . CYS B 1 299 ? 116.546 134.946 118.110 1.00 44.01  ? 299 CYS B CA  1 
ATOM   4308 C C   . CYS B 1 299 ? 115.347 135.439 117.310 1.00 44.01  ? 299 CYS B C   1 
ATOM   4309 O O   . CYS B 1 299 ? 115.271 135.234 116.090 1.00 44.01  ? 299 CYS B O   1 
ATOM   4310 C CB  . CYS B 1 299 ? 116.153 133.775 119.007 1.00 44.01  ? 299 CYS B CB  1 
ATOM   4311 S SG  . CYS B 1 299 ? 117.549 132.841 119.667 1.00 44.01  ? 299 CYS B SG  1 
ATOM   4312 N N   . THR B 1 300 ? 114.404 136.109 117.976 1.00 42.28  ? 300 THR B N   1 
ATOM   4313 C CA  . THR B 1 300 ? 113.185 136.529 117.295 1.00 42.28  ? 300 THR B CA  1 
ATOM   4314 C C   . THR B 1 300 ? 113.485 137.566 116.219 1.00 42.28  ? 300 THR B C   1 
ATOM   4315 O O   . THR B 1 300 ? 112.971 137.478 115.095 1.00 42.28  ? 300 THR B O   1 
ATOM   4316 C CB  . THR B 1 300 ? 112.186 137.075 118.309 1.00 42.28  ? 300 THR B CB  1 
ATOM   4317 O OG1 . THR B 1 300 ? 111.927 136.077 119.301 1.00 42.28  ? 300 THR B OG1 1 
ATOM   4318 C CG2 . THR B 1 300 ? 110.884 137.399 117.617 1.00 42.28  ? 300 THR B CG2 1 
ATOM   4319 N N   . THR B 1 301 ? 114.320 138.558 116.543 1.00 41.50  ? 301 THR B N   1 
ATOM   4320 C CA  . THR B 1 301 ? 114.658 139.586 115.571 1.00 41.50  ? 301 THR B CA  1 
ATOM   4321 C C   . THR B 1 301 ? 115.421 139.001 114.394 1.00 41.50  ? 301 THR B C   1 
ATOM   4322 O O   . THR B 1 301 ? 115.179 139.380 113.247 1.00 41.50  ? 301 THR B O   1 
ATOM   4323 C CB  . THR B 1 301 ? 115.458 140.698 116.245 1.00 41.50  ? 301 THR B CB  1 
ATOM   4324 O OG1 . THR B 1 301 ? 114.621 141.361 117.196 1.00 41.50  ? 301 THR B OG1 1 
ATOM   4325 C CG2 . THR B 1 301 ? 115.947 141.708 115.223 1.00 41.50  ? 301 THR B CG2 1 
ATOM   4326 N N   . THR B 1 302 ? 116.350 138.079 114.653 1.00 41.53  ? 302 THR B N   1 
ATOM   4327 C CA  . THR B 1 302 ? 117.094 137.454 113.568 1.00 41.53  ? 302 THR B CA  1 
ATOM   4328 C C   . THR B 1 302 ? 116.157 136.703 112.635 1.00 41.53  ? 302 THR B C   1 
ATOM   4329 O O   . THR B 1 302 ? 116.243 136.840 111.409 1.00 41.53  ? 302 THR B O   1 
ATOM   4330 C CB  . THR B 1 302 ? 118.146 136.508 114.146 1.00 41.53  ? 302 THR B CB  1 
ATOM   4331 O OG1 . THR B 1 302 ? 118.857 137.168 115.199 1.00 41.53  ? 302 THR B OG1 1 
ATOM   4332 C CG2 . THR B 1 302 ? 119.126 136.083 113.077 1.00 41.53  ? 302 THR B CG2 1 
ATOM   4333 N N   . ILE B 1 303 ? 115.230 135.927 113.202 1.00 42.03  ? 303 ILE B N   1 
ATOM   4334 C CA  . ILE B 1 303 ? 114.291 135.179 112.371 1.00 42.03  ? 303 ILE B CA  1 
ATOM   4335 C C   . ILE B 1 303 ? 113.455 136.127 111.524 1.00 42.03  ? 303 ILE B C   1 
ATOM   4336 O O   . ILE B 1 303 ? 113.357 135.972 110.301 1.00 42.03  ? 303 ILE B O   1 
ATOM   4337 C CB  . ILE B 1 303 ? 113.405 134.271 113.239 1.00 42.03  ? 303 ILE B CB  1 
ATOM   4338 C CG1 . ILE B 1 303 ? 114.219 133.095 113.757 1.00 42.03  ? 303 ILE B CG1 1 
ATOM   4339 C CG2 . ILE B 1 303 ? 112.207 133.781 112.443 1.00 42.03  ? 303 ILE B CG2 1 
ATOM   4340 C CD1 . ILE B 1 303 ? 114.700 132.217 112.645 1.00 42.03  ? 303 ILE B CD1 1 
ATOM   4341 N N   . ASN B 1 304 ? 112.854 137.134 112.159 1.00 42.59  ? 304 ASN B N   1 
ATOM   4342 C CA  . ASN B 1 304 ? 111.949 138.010 111.425 1.00 42.59  ? 304 ASN B CA  1 
ATOM   4343 C C   . ASN B 1 304 ? 112.695 138.842 110.388 1.00 42.59  ? 304 ASN B C   1 
ATOM   4344 O O   . ASN B 1 304 ? 112.184 139.067 109.284 1.00 42.59  ? 304 ASN B O   1 
ATOM   4345 C CB  . ASN B 1 304 ? 111.182 138.898 112.397 1.00 42.59  ? 304 ASN B CB  1 
ATOM   4346 C CG  . ASN B 1 304 ? 110.084 138.145 113.115 1.00 42.59  ? 304 ASN B CG  1 
ATOM   4347 O OD1 . ASN B 1 304 ? 108.991 137.961 112.583 1.00 42.59  ? 304 ASN B OD1 1 
ATOM   4348 N ND2 . ASN B 1 304 ? 110.372 137.697 114.329 1.00 42.59  ? 304 ASN B ND2 1 
ATOM   4349 N N   . CYS B 1 305 ? 113.902 139.308 110.719 1.00 42.50  ? 305 CYS B N   1 
ATOM   4350 C CA  . CYS B 1 305 ? 114.700 140.054 109.756 1.00 42.50  ? 305 CYS B CA  1 
ATOM   4351 C C   . CYS B 1 305 ? 115.064 139.187 108.559 1.00 42.50  ? 305 CYS B C   1 
ATOM   4352 O O   . CYS B 1 305 ? 114.919 139.614 107.410 1.00 42.50  ? 305 CYS B O   1 
ATOM   4353 C CB  . CYS B 1 305 ? 115.956 140.599 110.434 1.00 42.50  ? 305 CYS B CB  1 
ATOM   4354 S SG  . CYS B 1 305 ? 115.678 142.056 111.458 1.00 42.50  ? 305 CYS B SG  1 
ATOM   4355 N N   . PHE B 1 306 ? 115.501 137.948 108.804 1.00 41.31  ? 306 PHE B N   1 
ATOM   4356 C CA  . PHE B 1 306 ? 115.817 137.063 107.688 1.00 41.31  ? 306 PHE B CA  1 
ATOM   4357 C C   . PHE B 1 306 ? 114.592 136.810 106.824 1.00 41.31  ? 306 PHE B C   1 
ATOM   4358 O O   . PHE B 1 306 ? 114.697 136.726 105.596 1.00 41.31  ? 306 PHE B O   1 
ATOM   4359 C CB  . PHE B 1 306 ? 116.398 135.743 108.193 1.00 41.31  ? 306 PHE B CB  1 
ATOM   4360 C CG  . PHE B 1 306 ? 117.893 135.748 108.332 1.00 41.31  ? 306 PHE B CG  1 
ATOM   4361 C CD1 . PHE B 1 306 ? 118.700 135.692 107.212 1.00 41.31  ? 306 PHE B CD1 1 
ATOM   4362 C CD2 . PHE B 1 306 ? 118.492 135.783 109.577 1.00 41.31  ? 306 PHE B CD2 1 
ATOM   4363 C CE1 . PHE B 1 306 ? 120.071 135.693 107.330 1.00 41.31  ? 306 PHE B CE1 1 
ATOM   4364 C CE2 . PHE B 1 306 ? 119.862 135.781 109.698 1.00 41.31  ? 306 PHE B CE2 1 
ATOM   4365 C CZ  . PHE B 1 306 ? 120.652 135.736 108.575 1.00 41.31  ? 306 PHE B CZ  1 
ATOM   4366 N N   . ILE B 1 307 ? 113.420 136.682 107.447 1.00 41.47  ? 307 ILE B N   1 
ATOM   4367 C CA  . ILE B 1 307 ? 112.209 136.440 106.672 1.00 41.47  ? 307 ILE B CA  1 
ATOM   4368 C C   . ILE B 1 307 ? 111.855 137.652 105.818 1.00 41.47  ? 307 ILE B C   1 
ATOM   4369 O O   . ILE B 1 307 ? 111.515 137.513 104.637 1.00 41.47  ? 307 ILE B O   1 
ATOM   4370 C CB  . ILE B 1 307 ? 111.043 136.050 107.598 1.00 41.47  ? 307 ILE B CB  1 
ATOM   4371 C CG1 . ILE B 1 307 ? 111.357 134.765 108.363 1.00 41.47  ? 307 ILE B CG1 1 
ATOM   4372 C CG2 . ILE B 1 307 ? 109.769 135.873 106.796 1.00 41.47  ? 307 ILE B CG2 1 
ATOM   4373 C CD1 . ILE B 1 307 ? 111.537 133.557 107.490 1.00 41.47  ? 307 ILE B CD1 1 
ATOM   4374 N N   . PHE B 1 308 ? 111.934 138.858 106.386 1.00 41.80  ? 308 PHE B N   1 
ATOM   4375 C CA  . PHE B 1 308 ? 111.259 140.004 105.789 1.00 41.80  ? 308 PHE B CA  1 
ATOM   4376 C C   . PHE B 1 308 ? 112.162 141.022 105.106 1.00 41.80  ? 308 PHE B C   1 
ATOM   4377 O O   . PHE B 1 308 ? 111.690 141.714 104.203 1.00 41.80  ? 308 PHE B O   1 
ATOM   4378 C CB  . PHE B 1 308 ? 110.429 140.729 106.852 1.00 41.80  ? 308 PHE B CB  1 
ATOM   4379 C CG  . PHE B 1 308 ? 109.210 139.971 107.278 1.00 41.80  ? 308 PHE B CG  1 
ATOM   4380 C CD1 . PHE B 1 308 ? 108.166 139.765 106.394 1.00 41.80  ? 308 PHE B CD1 1 
ATOM   4381 C CD2 . PHE B 1 308 ? 109.111 139.456 108.556 1.00 41.80  ? 308 PHE B CD2 1 
ATOM   4382 C CE1 . PHE B 1 308 ? 107.046 139.066 106.780 1.00 41.80  ? 308 PHE B CE1 1 
ATOM   4383 C CE2 . PHE B 1 308 ? 107.994 138.755 108.944 1.00 41.80  ? 308 PHE B CE2 1 
ATOM   4384 C CZ  . PHE B 1 308 ? 106.960 138.561 108.057 1.00 41.80  ? 308 PHE B CZ  1 
ATOM   4385 N N   . ILE B 1 309 ? 113.430 141.158 105.506 1.00 42.64  ? 309 ILE B N   1 
ATOM   4386 C CA  . ILE B 1 309 ? 114.290 142.169 104.888 1.00 42.64  ? 309 ILE B CA  1 
ATOM   4387 C C   . ILE B 1 309 ? 114.471 141.927 103.394 1.00 42.64  ? 309 ILE B C   1 
ATOM   4388 O O   . ILE B 1 309 ? 114.381 142.896 102.620 1.00 42.64  ? 309 ILE B O   1 
ATOM   4389 C CB  . ILE B 1 309 ? 115.627 142.265 105.649 1.00 42.64  ? 309 ILE B CB  1 
ATOM   4390 C CG1 . ILE B 1 309 ? 115.401 142.798 107.063 1.00 42.64  ? 309 ILE B CG1 1 
ATOM   4391 C CG2 . ILE B 1 309 ? 116.600 143.162 104.908 1.00 42.64  ? 309 ILE B CG2 1 
ATOM   4392 C CD1 . ILE B 1 309 ? 114.891 144.218 107.107 1.00 42.64  ? 309 ILE B CD1 1 
ATOM   4393 N N   . PRO B 1 310 ? 114.740 140.704 102.920 1.00 42.16  ? 310 PRO B N   1 
ATOM   4394 C CA  . PRO B 1 310 ? 114.768 140.493 101.464 1.00 42.16  ? 310 PRO B CA  1 
ATOM   4395 C C   . PRO B 1 310 ? 113.477 140.895 100.777 1.00 42.16  ? 310 PRO B C   1 
ATOM   4396 O O   . PRO B 1 310 ? 113.515 141.470 99.683  1.00 42.16  ? 310 PRO B O   1 
ATOM   4397 C CB  . PRO B 1 310 ? 115.043 138.992 101.339 1.00 42.16  ? 310 PRO B CB  1 
ATOM   4398 C CG  . PRO B 1 310 ? 115.816 138.669 102.548 1.00 42.16  ? 310 PRO B CG  1 
ATOM   4399 C CD  . PRO B 1 310 ? 115.226 139.512 103.639 1.00 42.16  ? 310 PRO B CD  1 
ATOM   4400 N N   . GLN B 1 311 ? 112.326 140.566 101.366 1.00 44.53  ? 311 GLN B N   1 
ATOM   4401 C CA  . GLN B 1 311 ? 111.061 140.968 100.763 1.00 44.53  ? 311 GLN B CA  1 
ATOM   4402 C C   . GLN B 1 311 ? 111.024 142.471 100.539 1.00 44.53  ? 311 GLN B C   1 
ATOM   4403 O O   . GLN B 1 311 ? 110.646 142.935 99.458  1.00 44.53  ? 311 GLN B O   1 
ATOM   4404 C CB  . GLN B 1 311 ? 109.892 140.527 101.641 1.00 44.53  ? 311 GLN B CB  1 
ATOM   4405 C CG  . GLN B 1 311 ? 109.704 139.029 101.717 1.00 44.53  ? 311 GLN B CG  1 
ATOM   4406 C CD  . GLN B 1 311 ? 108.696 138.626 102.773 1.00 44.53  ? 311 GLN B CD  1 
ATOM   4407 O OE1 . GLN B 1 311 ? 108.648 137.470 103.193 1.00 44.53  ? 311 GLN B OE1 1 
ATOM   4408 N NE2 . GLN B 1 311 ? 107.884 139.581 103.210 1.00 44.53  ? 311 GLN B NE2 1 
ATOM   4409 N N   . LEU B 1 312 ? 111.456 143.243 101.537 1.00 45.35  ? 312 LEU B N   1 
ATOM   4410 C CA  . LEU B 1 312 ? 111.541 144.688 101.374 1.00 45.35  ? 312 LEU B CA  1 
ATOM   4411 C C   . LEU B 1 312 ? 112.522 145.065 100.276 1.00 45.35  ? 312 LEU B C   1 
ATOM   4412 O O   . LEU B 1 312 ? 112.256 145.979 99.487  1.00 45.35  ? 312 LEU B O   1 
ATOM   4413 C CB  . LEU B 1 312 ? 111.953 145.344 102.688 1.00 45.35  ? 312 LEU B CB  1 
ATOM   4414 C CG  . LEU B 1 312 ? 111.067 145.104 103.904 1.00 45.35  ? 312 LEU B CG  1 
ATOM   4415 C CD1 . LEU B 1 312 ? 111.922 145.100 105.145 1.00 45.35  ? 312 LEU B CD1 1 
ATOM   4416 C CD2 . LEU B 1 312 ? 109.997 146.170 103.997 1.00 45.35  ? 312 LEU B CD2 1 
ATOM   4417 N N   . LYS B 1 313 ? 113.669 144.385 100.214 1.00 46.61  ? 313 LYS B N   1 
ATOM   4418 C CA  . LYS B 1 313 ? 114.678 144.756 99.227  1.00 46.61  ? 313 LYS B CA  1 
ATOM   4419 C C   . LYS B 1 313 ? 114.154 144.584 97.806  1.00 46.61  ? 313 LYS B C   1 
ATOM   4420 O O   . LYS B 1 313 ? 114.209 145.517 96.996  1.00 46.61  ? 313 LYS B O   1 
ATOM   4421 C CB  . LYS B 1 313 ? 115.944 143.926 99.439  1.00 46.61  ? 313 LYS B CB  1 
ATOM   4422 C CG  . LYS B 1 313 ? 116.679 144.235 100.726 1.00 46.61  ? 313 LYS B CG  1 
ATOM   4423 C CD  . LYS B 1 313 ? 117.832 143.271 100.940 1.00 46.61  ? 313 LYS B CD  1 
ATOM   4424 C CE  . LYS B 1 313 ? 118.898 143.439 99.871  1.00 46.61  ? 313 LYS B CE  1 
ATOM   4425 N NZ  . LYS B 1 313 ? 119.589 144.754 99.977  1.00 46.61  ? 313 LYS B NZ  1 
ATOM   4426 N N   . GLN B 1 314 ? 113.624 143.400 97.484  1.00 49.28  ? 314 GLN B N   1 
ATOM   4427 C CA  . GLN B 1 314 ? 113.105 143.206 96.130  1.00 49.28  ? 314 GLN B CA  1 
ATOM   4428 C C   . GLN B 1 314 ? 111.815 143.979 95.875  1.00 49.28  ? 314 GLN B C   1 
ATOM   4429 O O   . GLN B 1 314 ? 111.544 144.336 94.723  1.00 49.28  ? 314 GLN B O   1 
ATOM   4430 C CB  . GLN B 1 314 ? 112.929 141.726 95.757  1.00 49.28  ? 314 GLN B CB  1 
ATOM   4431 C CG  . GLN B 1 314 ? 114.236 140.943 95.514  1.00 49.28  ? 314 GLN B CG  1 
ATOM   4432 C CD  . GLN B 1 314 ? 114.873 140.334 96.739  1.00 49.28  ? 314 GLN B CD  1 
ATOM   4433 O OE1 . GLN B 1 314 ? 114.226 140.139 97.755  1.00 49.28  ? 314 GLN B OE1 1 
ATOM   4434 N NE2 . GLN B 1 314 ? 116.162 140.029 96.643  1.00 49.28  ? 314 GLN B NE2 1 
ATOM   4435 N N   . TRP B 1 315 ? 111.011 144.263 96.903  1.00 52.91  ? 315 TRP B N   1 
ATOM   4436 C CA  . TRP B 1 315 ? 109.870 145.147 96.690  1.00 52.91  ? 315 TRP B CA  1 
ATOM   4437 C C   . TRP B 1 315 ? 110.331 146.534 96.263  1.00 52.91  ? 315 TRP B C   1 
ATOM   4438 O O   . TRP B 1 315 ? 109.870 147.070 95.249  1.00 52.91  ? 315 TRP B O   1 
ATOM   4439 C CB  . TRP B 1 315 ? 109.012 145.230 97.951  1.00 52.91  ? 315 TRP B CB  1 
ATOM   4440 C CG  . TRP B 1 315 ? 108.081 146.401 97.941  1.00 52.91  ? 315 TRP B CG  1 
ATOM   4441 C CD1 . TRP B 1 315 ? 107.066 146.630 97.062  1.00 52.91  ? 315 TRP B CD1 1 
ATOM   4442 C CD2 . TRP B 1 315 ? 108.076 147.503 98.855  1.00 52.91  ? 315 TRP B CD2 1 
ATOM   4443 N NE1 . TRP B 1 315 ? 106.430 147.808 97.367  1.00 52.91  ? 315 TRP B NE1 1 
ATOM   4444 C CE2 . TRP B 1 315 ? 107.031 148.363 98.465  1.00 52.91  ? 315 TRP B CE2 1 
ATOM   4445 C CE3 . TRP B 1 315 ? 108.854 147.847 99.964  1.00 52.91  ? 315 TRP B CE3 1 
ATOM   4446 C CZ2 . TRP B 1 315 ? 106.743 149.545 99.145  1.00 52.91  ? 315 TRP B CZ2 1 
ATOM   4447 C CZ3 . TRP B 1 315 ? 108.567 149.022 100.638 1.00 52.91  ? 315 TRP B CZ3 1 
ATOM   4448 C CH2 . TRP B 1 315 ? 107.521 149.856 100.226 1.00 52.91  ? 315 TRP B CH2 1 
ATOM   4449 N N   . LYS B 1 316 ? 111.252 147.130 97.025  1.00 54.43  ? 316 LYS B N   1 
ATOM   4450 C CA  . LYS B 1 316 ? 111.740 148.463 96.693  1.00 54.43  ? 316 LYS B CA  1 
ATOM   4451 C C   . LYS B 1 316 ? 112.450 148.468 95.346  1.00 54.43  ? 316 LYS B C   1 
ATOM   4452 O O   . LYS B 1 316 ? 112.369 149.448 94.597  1.00 54.43  ? 316 LYS B O   1 
ATOM   4453 C CB  . LYS B 1 316 ? 112.672 148.972 97.792  1.00 54.43  ? 316 LYS B CB  1 
ATOM   4454 C CG  . LYS B 1 316 ? 111.966 149.346 99.083  1.00 54.43  ? 316 LYS B CG  1 
ATOM   4455 C CD  . LYS B 1 316 ? 112.964 149.650 100.188 1.00 54.43  ? 316 LYS B CD  1 
ATOM   4456 C CE  . LYS B 1 316 ? 113.699 150.955 99.923  1.00 54.43  ? 316 LYS B CE  1 
ATOM   4457 N NZ  . LYS B 1 316 ? 114.633 151.303 101.030 1.00 54.43  ? 316 LYS B NZ  1 
ATOM   4458 N N   . ALA B 1 317 ? 113.158 147.382 95.022  1.00 56.90  ? 317 ALA B N   1 
ATOM   4459 C CA  . ALA B 1 317 ? 113.801 147.289 93.717  1.00 56.90  ? 317 ALA B CA  1 
ATOM   4460 C C   . ALA B 1 317 ? 112.769 147.228 92.598  1.00 56.90  ? 317 ALA B C   1 
ATOM   4461 O O   . ALA B 1 317 ? 112.964 147.825 91.533  1.00 56.90  ? 317 ALA B O   1 
ATOM   4462 C CB  . ALA B 1 317 ? 114.720 146.069 93.669  1.00 56.90  ? 317 ALA B CB  1 
ATOM   4463 N N   . PHE B 1 318 ? 111.666 146.514 92.820  1.00 59.46  ? 318 PHE B N   1 
ATOM   4464 C CA  . PHE B 1 318 ? 110.649 146.333 91.790  1.00 59.46  ? 318 PHE B CA  1 
ATOM   4465 C C   . PHE B 1 318 ? 109.583 147.422 91.862  1.00 59.46  ? 318 PHE B C   1 
ATOM   4466 O O   . PHE B 1 318 ? 109.383 148.166 90.896  1.00 59.46  ? 318 PHE B O   1 
ATOM   4467 C CB  . PHE B 1 318 ? 110.014 144.944 91.923  1.00 59.46  ? 318 PHE B CB  1 
ATOM   4468 C CG  . PHE B 1 318 ? 108.998 144.635 90.860  1.00 59.46  ? 318 PHE B CG  1 
ATOM   4469 C CD1 . PHE B 1 318 ? 109.398 144.259 89.589  1.00 59.46  ? 318 PHE B CD1 1 
ATOM   4470 C CD2 . PHE B 1 318 ? 107.643 144.719 91.134  1.00 59.46  ? 318 PHE B CD2 1 
ATOM   4471 C CE1 . PHE B 1 318 ? 108.465 143.974 88.609  1.00 59.46  ? 318 PHE B CE1 1 
ATOM   4472 C CE2 . PHE B 1 318 ? 106.705 144.436 90.159  1.00 59.46  ? 318 PHE B CE2 1 
ATOM   4473 C CZ  . PHE B 1 318 ? 107.117 144.062 88.895  1.00 59.46  ? 318 PHE B CZ  1 
ATOM   4474 N N   . GLU B 1 319 ? 108.902 147.526 93.000  1.00 60.50  ? 319 GLU B N   1 
ATOM   4475 C CA  . GLU B 1 319 ? 107.835 148.505 93.203  1.00 60.50  ? 319 GLU B CA  1 
ATOM   4476 C C   . GLU B 1 319 ? 106.772 148.426 92.111  1.00 60.50  ? 319 GLU B C   1 
ATOM   4477 O O   . GLU B 1 319 ? 105.726 149.068 92.202  1.00 60.50  ? 319 GLU B O   1 
ATOM   4478 C CB  . GLU B 1 319 ? 108.414 149.921 93.273  1.00 60.50  ? 319 GLU B CB  1 
ATOM   4479 C CG  . GLU B 1 319 ? 108.954 150.300 94.643  1.00 60.50  ? 319 GLU B CG  1 
ATOM   4480 C CD  . GLU B 1 319 ? 109.929 151.460 94.587  1.00 60.50  ? 319 GLU B CD  1 
ATOM   4481 O OE1 . GLU B 1 319 ? 110.647 151.588 93.573  1.00 60.50  ? 319 GLU B OE1 1 
ATOM   4482 O OE2 . GLU B 1 319 ? 109.977 152.244 95.558  1.00 60.50  ? 319 GLU B OE2 1 
HETATM 4483 C C   . MW9 C 2 .   ? 121.509 95.133  125.099 1.00 52.93  ? 401 MW9 A C   1 
HETATM 4484 O O   . MW9 C 2 .   ? 114.327 92.672  138.729 1.00 52.93  ? 401 MW9 A O   1 
HETATM 4485 C C1  . MW9 C 2 .   ? 119.976 95.090  125.282 1.00 52.93  ? 401 MW9 A C1  1 
HETATM 4486 C C10 . MW9 C 2 .   ? 113.851 91.833  130.741 1.00 52.93  ? 401 MW9 A C10 1 
HETATM 4487 C C11 . MW9 C 2 .   ? 113.843 91.371  132.219 1.00 52.93  ? 401 MW9 A C11 1 
HETATM 4488 C C12 . MW9 C 2 .   ? 115.192 90.686  132.567 1.00 52.93  ? 401 MW9 A C12 1 
HETATM 4489 C C13 . MW9 C 2 .   ? 115.637 91.094  133.999 1.00 52.93  ? 401 MW9 A C13 1 
HETATM 4490 C C14 . MW9 C 2 .   ? 114.856 90.253  135.043 1.00 52.93  ? 401 MW9 A C14 1 
HETATM 4491 C C15 . MW9 C 2 .   ? 115.327 90.623  136.474 1.00 52.93  ? 401 MW9 A C15 1 
HETATM 4492 C C16 . MW9 C 2 .   ? 115.339 92.165  136.639 1.00 52.93  ? 401 MW9 A C16 1 
HETATM 4493 C C17 . MW9 C 2 .   ? 114.167 92.595  137.552 1.00 52.93  ? 401 MW9 A C17 1 
HETATM 4494 C C18 . MW9 C 2 .   ? 112.433 94.201  137.287 1.00 52.93  ? 401 MW9 A C18 1 
HETATM 4495 C C19 . MW9 C 2 .   ? 113.278 95.239  136.537 1.00 52.93  ? 401 MW9 A C19 1 
HETATM 4496 C C2  . MW9 C 2 .   ? 119.334 94.380  124.068 1.00 52.93  ? 401 MW9 A C2  1 
HETATM 4497 C C20 . MW9 C 2 .   ? 113.460 96.479  137.426 1.00 52.93  ? 401 MW9 A C20 1 
HETATM 4498 C C21 . MW9 C 2 .   ? 113.193 97.426  142.150 1.00 52.93  ? 401 MW9 A C21 1 
HETATM 4499 C C22 . MW9 C 2 .   ? 113.766 98.591  142.967 1.00 52.93  ? 401 MW9 A C22 1 
HETATM 4500 C C23 . MW9 C 2 .   ? 114.998 98.117  143.748 1.00 52.93  ? 401 MW9 A C23 1 
HETATM 4501 C C24 . MW9 C 2 .   ? 113.448 96.299  134.433 1.00 52.93  ? 401 MW9 A C24 1 
HETATM 4502 C C25 . MW9 C 2 .   ? 114.399 95.540  133.475 1.00 52.93  ? 401 MW9 A C25 1 
HETATM 4503 C C26 . MW9 C 2 .   ? 114.650 96.412  132.218 1.00 52.93  ? 401 MW9 A C26 1 
HETATM 4504 C C27 . MW9 C 2 .   ? 114.169 95.667  130.945 1.00 52.93  ? 401 MW9 A C27 1 
HETATM 4505 C C28 . MW9 C 2 .   ? 114.042 96.689  129.782 1.00 52.93  ? 401 MW9 A C28 1 
HETATM 4506 C C29 . MW9 C 2 .   ? 114.205 95.961  128.421 1.00 52.93  ? 401 MW9 A C29 1 
HETATM 4507 C C3  . MW9 C 2 .   ? 117.913 93.886  124.440 1.00 52.93  ? 401 MW9 A C3  1 
HETATM 4508 C C30 . MW9 C 2 .   ? 115.320 96.660  127.600 1.00 52.93  ? 401 MW9 A C30 1 
HETATM 4509 C C31 . MW9 C 2 .   ? 114.814 98.048  127.131 1.00 52.93  ? 401 MW9 A C31 1 
HETATM 4510 C C32 . MW9 C 2 .   ? 115.341 98.339  125.702 1.00 52.93  ? 401 MW9 A C32 1 
HETATM 4511 C C33 . MW9 C 2 .   ? 115.586 99.636  125.521 1.00 52.93  ? 401 MW9 A C33 1 
HETATM 4512 C C34 . MW9 C 2 .   ? 116.043 100.844 124.675 1.00 52.93  ? 401 MW9 A C34 1 
HETATM 4513 C C35 . MW9 C 2 .   ? 115.359 102.125 125.200 1.00 52.93  ? 401 MW9 A C35 1 
HETATM 4514 C C36 . MW9 C 2 .   ? 115.151 103.124 124.036 1.00 52.93  ? 401 MW9 A C36 1 
HETATM 4515 C C37 . MW9 C 2 .   ? 114.588 102.380 122.800 1.00 52.93  ? 401 MW9 A C37 1 
HETATM 4516 C C38 . MW9 C 2 .   ? 115.398 102.782 121.545 1.00 52.93  ? 401 MW9 A C38 1 
HETATM 4517 C C39 . MW9 C 2 .   ? 114.741 104.016 120.878 1.00 52.93  ? 401 MW9 A C39 1 
HETATM 4518 C C4  . MW9 C 2 .   ? 117.977 92.989  125.704 1.00 52.93  ? 401 MW9 A C4  1 
HETATM 4519 C C40 . MW9 C 2 .   ? 115.786 105.148 120.751 1.00 52.93  ? 401 MW9 A C40 1 
HETATM 4520 C C41 . MW9 C 2 .   ? 117.052 104.607 120.052 1.00 52.93  ? 401 MW9 A C41 1 
HETATM 4521 C C5  . MW9 C 2 .   ? 116.892 93.444  126.714 1.00 52.93  ? 401 MW9 A C5  1 
HETATM 4522 C C6  . MW9 C 2 .   ? 117.247 92.919  128.127 1.00 52.93  ? 401 MW9 A C6  1 
HETATM 4523 C C7  . MW9 C 2 .   ? 115.950 92.742  128.957 1.00 52.93  ? 401 MW9 A C7  1 
HETATM 4524 C C8  . MW9 C 2 .   ? 115.607 91.240  129.058 1.00 52.93  ? 401 MW9 A C8  1 
HETATM 4525 C C9  . MW9 C 2 .   ? 114.638 90.822  129.877 1.00 52.93  ? 401 MW9 A C9  1 
HETATM 4526 O O1  . MW9 C 2 .   ? 112.903 92.899  136.985 1.00 52.93  ? 401 MW9 A O1  1 
HETATM 4527 O O2  . MW9 C 2 .   ? 113.765 96.067  138.746 1.00 52.93  ? 401 MW9 A O2  1 
HETATM 4528 O O3  . MW9 C 2 .   ? 115.451 96.538  140.662 1.00 52.93  ? 401 MW9 A O3  1 
HETATM 4529 O O4  . MW9 C 2 .   ? 115.004 98.321  139.020 1.00 52.93  ? 401 MW9 A O4  1 
HETATM 4530 O O5  . MW9 C 2 .   ? 113.178 97.767  140.776 1.00 52.93  ? 401 MW9 A O5  1 
HETATM 4531 O O6  . MW9 C 2 .   ? 115.474 96.918  143.187 1.00 52.93  ? 401 MW9 A O6  1 
HETATM 4532 O O7  . MW9 C 2 .   ? 112.799 99.050  143.863 1.00 52.93  ? 401 MW9 A O7  1 
HETATM 4533 O O8  . MW9 C 2 .   ? 112.634 95.590  135.348 1.00 52.93  ? 401 MW9 A O8  1 
HETATM 4534 O O9  . MW9 C 2 .   ? 113.396 97.481  134.390 1.00 52.93  ? 401 MW9 A O9  1 
HETATM 4535 P P   . MW9 C 2 .   ? 114.390 97.186  139.803 1.00 52.93  ? 401 MW9 A P   1 
HETATM 4536 C C   . MW9 D 2 .   ? 122.208 114.846 122.009 1.00 48.47  ? 402 MW9 A C   1 
HETATM 4537 O O   . MW9 D 2 .   ? 128.305 114.987 136.499 1.00 48.47  ? 402 MW9 A O   1 
HETATM 4538 C C1  . MW9 D 2 .   ? 122.840 113.463 121.754 1.00 48.47  ? 402 MW9 A C1  1 
HETATM 4539 C C10 . MW9 D 2 .   ? 130.071 112.507 127.608 1.00 48.47  ? 402 MW9 A C10 1 
HETATM 4540 C C11 . MW9 D 2 .   ? 129.350 112.686 128.964 1.00 48.47  ? 402 MW9 A C11 1 
HETATM 4541 C C12 . MW9 D 2 .   ? 129.220 114.199 129.269 1.00 48.47  ? 402 MW9 A C12 1 
HETATM 4542 C C13 . MW9 D 2 .   ? 128.220 114.390 130.437 1.00 48.47  ? 402 MW9 A C13 1 
HETATM 4543 C C14 . MW9 D 2 .   ? 129.005 114.390 131.772 1.00 48.47  ? 402 MW9 A C14 1 
HETATM 4544 C C15 . MW9 D 2 .   ? 128.022 114.668 132.935 1.00 48.47  ? 402 MW9 A C15 1 
HETATM 4545 C C16 . MW9 D 2 .   ? 128.811 115.132 134.184 1.00 48.47  ? 402 MW9 A C16 1 
HETATM 4546 C C17 . MW9 D 2 .   ? 128.174 114.484 135.432 1.00 48.47  ? 402 MW9 A C17 1 
HETATM 4547 C C18 . MW9 D 2 .   ? 126.438 113.123 136.287 1.00 48.47  ? 402 MW9 A C18 1 
HETATM 4548 C C19 . MW9 D 2 .   ? 125.449 112.042 135.837 1.00 48.47  ? 402 MW9 A C19 1 
HETATM 4549 C C2  . MW9 D 2 .   ? 124.226 113.397 122.431 1.00 48.47  ? 402 MW9 A C2  1 
HETATM 4550 C C20 . MW9 D 2 .   ? 124.334 111.916 136.883 1.00 48.47  ? 402 MW9 A C20 1 
HETATM 4551 C C21 . MW9 D 2 .   ? 122.568 114.663 140.527 1.00 48.47  ? 402 MW9 A C21 1 
HETATM 4552 C C22 . MW9 D 2 .   ? 122.593 116.107 141.043 1.00 48.47  ? 402 MW9 A C22 1 
HETATM 4553 C C23 . MW9 D 2 .   ? 124.036 116.631 141.032 1.00 48.47  ? 402 MW9 A C23 1 
HETATM 4554 C C24 . MW9 D 2 .   ? 125.550 109.928 134.773 1.00 48.47  ? 402 MW9 A C24 1 
HETATM 4555 C C25 . MW9 D 2 .   ? 124.626 110.453 133.641 1.00 48.47  ? 402 MW9 A C25 1 
HETATM 4556 C C26 . MW9 D 2 .   ? 125.472 110.795 132.386 1.00 48.47  ? 402 MW9 A C26 1 
HETATM 4557 C C27 . MW9 D 2 .   ? 124.742 110.263 131.126 1.00 48.47  ? 402 MW9 A C27 1 
HETATM 4558 C C28 . MW9 D 2 .   ? 124.745 108.711 131.152 1.00 48.47  ? 402 MW9 A C28 1 
HETATM 4559 C C29 . MW9 D 2 .   ? 123.681 108.179 130.159 1.00 48.47  ? 402 MW9 A C29 1 
HETATM 4560 C C3  . MW9 D 2 .   ? 124.922 112.073 122.029 1.00 48.47  ? 402 MW9 A C3  1 
HETATM 4561 C C30 . MW9 D 2 .   ? 124.372 107.854 128.809 1.00 48.47  ? 402 MW9 A C30 1 
HETATM 4562 C C31 . MW9 D 2 .   ? 123.861 108.810 127.699 1.00 48.47  ? 402 MW9 A C31 1 
HETATM 4563 C C32 . MW9 D 2 .   ? 122.713 108.101 126.941 1.00 48.47  ? 402 MW9 A C32 1 
HETATM 4564 C C33 . MW9 D 2 .   ? 122.929 107.985 125.633 1.00 48.47  ? 402 MW9 A C33 1 
HETATM 4565 C C34 . MW9 D 2 .   ? 123.758 108.191 124.351 1.00 48.47  ? 402 MW9 A C34 1 
HETATM 4566 C C35 . MW9 D 2 .   ? 123.691 106.911 123.498 1.00 48.47  ? 402 MW9 A C35 1 
HETATM 4567 C C36 . MW9 D 2 .   ? 124.807 106.951 122.430 1.00 48.47  ? 402 MW9 A C36 1 
HETATM 4568 C C37 . MW9 D 2 .   ? 124.402 106.045 121.245 1.00 48.47  ? 402 MW9 A C37 1 
HETATM 4569 C C38 . MW9 D 2 .   ? 125.583 105.945 120.257 1.00 48.47  ? 402 MW9 A C38 1 
HETATM 4570 C C39 . MW9 D 2 .   ? 125.124 106.418 118.856 1.00 48.47  ? 402 MW9 A C39 1 
HETATM 4571 C C4  . MW9 D 2 .   ? 126.278 111.953 122.772 1.00 48.47  ? 402 MW9 A C4  1 
HETATM 4572 C C40 . MW9 D 2 .   ? 126.059 105.820 117.781 1.00 48.47  ? 402 MW9 A C40 1 
HETATM 4573 C C41 . MW9 D 2 .   ? 127.521 105.945 118.260 1.00 48.47  ? 402 MW9 A C41 1 
HETATM 4574 C C5  . MW9 D 2 .   ? 126.444 110.509 123.308 1.00 48.47  ? 402 MW9 A C5  1 
HETATM 4575 C C6  . MW9 D 2 .   ? 127.349 110.517 124.565 1.00 48.47  ? 402 MW9 A C6  1 
HETATM 4576 C C7  . MW9 D 2 .   ? 126.854 111.600 125.554 1.00 48.47  ? 402 MW9 A C7  1 
HETATM 4577 C C8  . MW9 D 2 .   ? 127.871 111.736 126.703 1.00 48.47  ? 402 MW9 A C8  1 
HETATM 4578 C C9  . MW9 D 2 .   ? 129.029 112.355 126.478 1.00 48.47  ? 402 MW9 A C9  1 
HETATM 4579 O O1  . MW9 D 2 .   ? 127.435 113.285 135.298 1.00 48.47  ? 402 MW9 A O1  1 
HETATM 4580 O O2  . MW9 D 2 .   ? 123.653 113.153 136.998 1.00 48.47  ? 402 MW9 A O2  1 
HETATM 4581 O O3  . MW9 D 2 .   ? 122.619 112.079 139.111 1.00 48.47  ? 402 MW9 A O3  1 
HETATM 4582 O O4  . MW9 D 2 .   ? 121.189 113.508 137.697 1.00 48.47  ? 402 MW9 A O4  1 
HETATM 4583 O O5  . MW9 D 2 .   ? 122.988 114.638 139.176 1.00 48.47  ? 402 MW9 A O5  1 
HETATM 4584 O O6  . MW9 D 2 .   ? 124.582 116.475 139.745 1.00 48.47  ? 402 MW9 A O6  1 
HETATM 4585 O O7  . MW9 D 2 .   ? 122.094 116.143 142.347 1.00 48.47  ? 402 MW9 A O7  1 
HETATM 4586 O O8  . MW9 D 2 .   ? 126.119 110.823 135.713 1.00 48.47  ? 402 MW9 A O8  1 
HETATM 4587 O O9  . MW9 D 2 .   ? 125.783 108.768 134.850 1.00 48.47  ? 402 MW9 A O9  1 
HETATM 4588 P P   . MW9 D 2 .   ? 122.580 113.321 138.253 1.00 48.47  ? 402 MW9 A P   1 
HETATM 4589 C C1  . CLR E 3 .   ? 107.520 102.372 133.813 1.00 20.00  ? 403 CLR A C1  1 
HETATM 4590 C C2  . CLR E 3 .   ? 107.128 102.633 135.261 1.00 20.00  ? 403 CLR A C2  1 
HETATM 4591 C C3  . CLR E 3 .   ? 108.355 103.025 136.068 1.00 20.00  ? 403 CLR A C3  1 
HETATM 4592 C C4  . CLR E 3 .   ? 108.850 104.358 135.538 1.00 20.00  ? 403 CLR A C4  1 
HETATM 4593 C C5  . CLR E 3 .   ? 109.132 104.227 134.062 1.00 20.00  ? 403 CLR A C5  1 
HETATM 4594 C C6  . CLR E 3 .   ? 110.315 104.679 133.630 1.00 20.00  ? 403 CLR A C6  1 
HETATM 4595 C C7  . CLR E 3 .   ? 110.751 104.661 132.194 1.00 20.00  ? 403 CLR A C7  1 
HETATM 4596 C C8  . CLR E 3 .   ? 109.578 104.359 131.296 1.00 20.00  ? 403 CLR A C8  1 
HETATM 4597 C C9  . CLR E 3 .   ? 108.714 103.226 131.815 1.00 20.00  ? 403 CLR A C9  1 
HETATM 4598 C C10 . CLR E 3 .   ? 108.095 103.616 133.153 1.00 20.00  ? 403 CLR A C10 1 
HETATM 4599 C C11 . CLR E 3 .   ? 107.654 102.786 130.788 1.00 20.00  ? 403 CLR A C11 1 
HETATM 4600 C C12 . CLR E 3 .   ? 108.172 102.630 129.354 1.00 20.00  ? 403 CLR A C12 1 
HETATM 4601 C C13 . CLR E 3 .   ? 108.975 103.839 128.930 1.00 20.00  ? 403 CLR A C13 1 
HETATM 4602 C C14 . CLR E 3 .   ? 110.087 103.956 129.939 1.00 20.00  ? 403 CLR A C14 1 
HETATM 4603 C C15 . CLR E 3 .   ? 111.099 104.912 129.346 1.00 20.00  ? 403 CLR A C15 1 
HETATM 4604 C C16 . CLR E 3 .   ? 110.966 104.694 127.845 1.00 20.00  ? 403 CLR A C16 1 
HETATM 4605 C C17 . CLR E 3 .   ? 109.758 103.781 127.631 1.00 20.00  ? 403 CLR A C17 1 
HETATM 4606 C C18 . CLR E 3 .   ? 108.078 105.077 128.897 1.00 20.00  ? 403 CLR A C18 1 
HETATM 4607 C C19 . CLR E 3 .   ? 106.984 104.643 132.979 1.00 20.00  ? 403 CLR A C19 1 
HETATM 4608 C C20 . CLR E 3 .   ? 109.023 104.184 126.361 1.00 20.00  ? 403 CLR A C20 1 
HETATM 4609 C C21 . CLR E 3 .   ? 107.828 103.274 126.113 1.00 20.00  ? 403 CLR A C21 1 
HETATM 4610 C C22 . CLR E 3 .   ? 110.046 104.194 125.228 1.00 20.00  ? 403 CLR A C22 1 
HETATM 4611 C C23 . CLR E 3 .   ? 109.475 103.911 123.847 1.00 20.00  ? 403 CLR A C23 1 
HETATM 4612 C C24 . CLR E 3 .   ? 109.508 102.416 123.575 1.00 20.00  ? 403 CLR A C24 1 
HETATM 4613 C C25 . CLR E 3 .   ? 108.324 101.987 122.726 1.00 20.00  ? 403 CLR A C25 1 
HETATM 4614 C C26 . CLR E 3 .   ? 108.781 100.958 121.708 1.00 20.00  ? 403 CLR A C26 1 
HETATM 4615 C C27 . CLR E 3 .   ? 107.185 101.434 123.570 1.00 20.00  ? 403 CLR A C27 1 
HETATM 4616 O O1  . CLR E 3 .   ? 108.030 103.145 137.457 1.00 20.00  ? 403 CLR A O1  1 
HETATM 4617 C C1  . CLR F 3 .   ? 119.031 97.582  108.572 1.00 20.00  ? 404 CLR A C1  1 
HETATM 4618 C C2  . CLR F 3 .   ? 118.714 98.235  107.236 1.00 20.00  ? 404 CLR A C2  1 
HETATM 4619 C C3  . CLR F 3 .   ? 117.757 97.359  106.446 1.00 20.00  ? 404 CLR A C3  1 
HETATM 4620 C C4  . CLR F 3 .   ? 116.439 97.289  107.198 1.00 20.00  ? 404 CLR A C4  1 
HETATM 4621 C C5  . CLR F 3 .   ? 116.687 96.788  108.599 1.00 20.00  ? 404 CLR A C5  1 
HETATM 4622 C C6  . CLR F 3 .   ? 115.904 95.796  109.054 1.00 20.00  ? 404 CLR A C6  1 
HETATM 4623 C C7  . CLR F 3 .   ? 116.035 95.208  110.438 1.00 20.00  ? 404 CLR A C7  1 
HETATM 4624 C C8  . CLR F 3 .   ? 116.840 96.124  111.330 1.00 20.00  ? 404 CLR A C8  1 
HETATM 4625 C C9  . CLR F 3 .   ? 118.121 96.539  110.623 1.00 20.00  ? 404 CLR A C9  1 
HETATM 4626 C C10 . CLR F 3 .   ? 117.783 97.417  109.424 1.00 20.00  ? 404 CLR A C10 1 
HETATM 4627 C C11 . CLR F 3 .   ? 119.148 97.223  111.540 1.00 20.00  ? 404 CLR A C11 1 
HETATM 4628 C C12 . CLR F 3 .   ? 119.328 96.546  112.898 1.00 20.00  ? 404 CLR A C12 1 
HETATM 4629 C C13 . CLR F 3 .   ? 117.986 96.319  113.551 1.00 20.00  ? 404 CLR A C13 1 
HETATM 4630 C C14 . CLR F 3 .   ? 117.180 95.435  112.633 1.00 20.00  ? 404 CLR A C14 1 
HETATM 4631 C C15 . CLR F 3 .   ? 115.997 94.984  113.473 1.00 20.00  ? 404 CLR A C15 1 
HETATM 4632 C C16 . CLR F 3 .   ? 116.549 94.932  114.895 1.00 20.00  ? 404 CLR A C16 1 
HETATM 4633 C C17 . CLR F 3 .   ? 117.955 95.526  114.844 1.00 20.00  ? 404 CLR A C17 1 
HETATM 4634 C C18 . CLR F 3 .   ? 117.299 97.663  113.787 1.00 20.00  ? 404 CLR A C18 1 
HETATM 4635 C C19 . CLR F 3 .   ? 117.296 98.798  109.848 1.00 20.00  ? 404 CLR A C19 1 
HETATM 4636 C C20 . CLR F 3 .   ? 118.273 96.298  116.116 1.00 20.00  ? 404 CLR A C20 1 
HETATM 4637 C C21 . CLR F 3 .   ? 119.654 96.933  116.064 1.00 20.00  ? 404 CLR A C21 1 
HETATM 4638 C C22 . CLR F 3 .   ? 118.161 95.376  117.320 1.00 20.00  ? 404 CLR A C22 1 
HETATM 4639 C C23 . CLR F 3 .   ? 116.937 95.715  118.156 1.00 20.00  ? 404 CLR A C23 1 
HETATM 4640 C C24 . CLR F 3 .   ? 117.072 95.128  119.551 1.00 20.00  ? 404 CLR A C24 1 
HETATM 4641 C C25 . CLR F 3 .   ? 115.811 95.395  120.357 1.00 20.00  ? 404 CLR A C25 1 
HETATM 4642 C C26 . CLR F 3 .   ? 115.064 94.097  120.616 1.00 20.00  ? 404 CLR A C26 1 
HETATM 4643 C C27 . CLR F 3 .   ? 116.129 96.102  121.665 1.00 20.00  ? 404 CLR A C27 1 
HETATM 4644 O O1  . CLR F 3 .   ? 117.548 97.922  105.147 1.00 20.00  ? 404 CLR A O1  1 
HETATM 4645 C C1  . CLR G 3 .   ? 118.641 118.845 129.665 1.00 20.00  ? 405 CLR A C1  1 
HETATM 4646 C C2  . CLR G 3 .   ? 119.232 119.002 131.058 1.00 20.00  ? 405 CLR A C2  1 
HETATM 4647 C C3  . CLR G 3 .   ? 120.737 118.831 130.992 1.00 20.00  ? 405 CLR A C3  1 
HETATM 4648 C C4  . CLR G 3 .   ? 121.259 120.094 130.343 1.00 20.00  ? 405 CLR A C4  1 
HETATM 4649 C C5  . CLR G 3 .   ? 120.695 120.169 128.947 1.00 20.00  ? 405 CLR A C5  1 
HETATM 4650 C C6  . CLR G 3 .   ? 121.468 120.674 127.984 1.00 20.00  ? 405 CLR A C6  1 
HETATM 4651 C C7  . CLR G 3 .   ? 121.577 119.954 126.669 1.00 20.00  ? 405 CLR A C7  1 
HETATM 4652 C C8  . CLR G 3 .   ? 120.177 119.584 126.226 1.00 20.00  ? 405 CLR A C8  1 
HETATM 4653 C C9  . CLR G 3 .   ? 119.377 118.891 127.319 1.00 20.00  ? 405 CLR A C9  1 
HETATM 4654 C C10 . CLR G 3 .   ? 119.296 119.716 128.597 1.00 20.00  ? 405 CLR A C10 1 
HETATM 4655 C C11 . CLR G 3 .   ? 117.980 118.528 126.814 1.00 20.00  ? 405 CLR A C11 1 
HETATM 4656 C C12 . CLR G 3 .   ? 118.020 117.704 125.527 1.00 20.00  ? 405 CLR A C12 1 
HETATM 4657 C C13 . CLR G 3 .   ? 118.825 118.479 124.504 1.00 20.00  ? 405 CLR A C13 1 
HETATM 4658 C C14 . CLR G 3 .   ? 120.221 118.638 125.049 1.00 20.00  ? 405 CLR A C14 1 
HETATM 4659 C C15 . CLR G 3 .   ? 121.063 119.045 123.853 1.00 20.00  ? 405 CLR A C15 1 
HETATM 4660 C C16 . CLR G 3 .   ? 120.451 118.238 122.710 1.00 20.00  ? 405 CLR A C16 1 
HETATM 4661 C C17 . CLR G 3 .   ? 119.040 117.842 123.144 1.00 20.00  ? 405 CLR A C17 1 
HETATM 4662 C C18 . CLR G 3 .   ? 118.197 119.855 124.306 1.00 20.00  ? 405 CLR A C18 1 
HETATM 4663 C C19 . CLR G 3 .   ? 118.442 120.955 128.357 1.00 20.00  ? 405 CLR A C19 1 
HETATM 4664 C C20 . CLR G 3 .   ? 117.968 118.241 122.135 1.00 20.00  ? 405 CLR A C20 1 
HETATM 4665 C C21 . CLR G 3 .   ? 116.739 117.345 122.248 1.00 20.00  ? 405 CLR A C21 1 
HETATM 4666 C C22 . CLR G 3 .   ? 118.524 118.243 120.715 1.00 20.00  ? 405 CLR A C22 1 
HETATM 4667 C C23 . CLR G 3 .   ? 118.926 119.651 120.298 1.00 20.00  ? 405 CLR A C23 1 
HETATM 4668 C C24 . CLR G 3 .   ? 119.883 119.594 119.119 1.00 20.00  ? 405 CLR A C24 1 
HETATM 4669 C C25 . CLR G 3 .   ? 119.244 118.878 117.939 1.00 20.00  ? 405 CLR A C25 1 
HETATM 4670 C C26 . CLR G 3 .   ? 118.148 119.731 117.309 1.00 20.00  ? 405 CLR A C26 1 
HETATM 4671 C C27 . CLR G 3 .   ? 120.311 118.484 116.926 1.00 20.00  ? 405 CLR A C27 1 
HETATM 4672 O O1  . CLR G 3 .   ? 121.287 118.695 132.302 1.00 20.00  ? 405 CLR A O1  1 
HETATM 4673 C C1  . CLR H 3 .   ? 132.379 125.864 135.901 1.00 20.00  ? 406 CLR A C1  1 
HETATM 4674 C C2  . CLR H 3 .   ? 132.472 126.144 137.392 1.00 20.00  ? 406 CLR A C2  1 
HETATM 4675 C C3  . CLR H 3 .   ? 133.895 125.926 137.875 1.00 20.00  ? 406 CLR A C3  1 
HETATM 4676 C C4  . CLR H 3 .   ? 134.791 126.948 137.199 1.00 20.00  ? 406 CLR A C4  1 
HETATM 4677 C C5  . CLR H 3 .   ? 134.644 126.828 135.704 1.00 20.00  ? 406 CLR A C5  1 
HETATM 4678 C C6  . CLR H 3 .   ? 135.768 126.755 134.974 1.00 20.00  ? 406 CLR A C6  1 
HETATM 4679 C C7  . CLR H 3 .   ? 135.768 126.641 133.470 1.00 20.00  ? 406 CLR A C7  1 
HETATM 4680 C C8  . CLR H 3 .   ? 134.422 127.039 132.912 1.00 20.00  ? 406 CLR A C8  1 
HETATM 4681 C C9  . CLR H 3 .   ? 133.313 126.316 133.658 1.00 20.00  ? 406 CLR A C9  1 
HETATM 4682 C C10 . CLR H 3 .   ? 133.263 126.806 135.100 1.00 20.00  ? 406 CLR A C10 1 
HETATM 4683 C C11 . CLR H 3 .   ? 131.937 126.430 132.984 1.00 20.00  ? 406 CLR A C11 1 
HETATM 4684 C C12 . CLR H 3 .   ? 131.962 126.205 131.473 1.00 20.00  ? 406 CLR A C12 1 
HETATM 4685 C C13 . CLR H 3 .   ? 133.016 127.078 130.836 1.00 20.00  ? 406 CLR A C13 1 
HETATM 4686 C C14 . CLR H 3 .   ? 134.344 126.700 131.440 1.00 20.00  ? 406 CLR A C14 1 
HETATM 4687 C C15 . CLR H 3 .   ? 135.376 127.374 130.551 1.00 20.00  ? 406 CLR A C15 1 
HETATM 4688 C C16 . CLR H 3 .   ? 134.729 127.368 129.171 1.00 20.00  ? 406 CLR A C16 1 
HETATM 4689 C C17 . CLR H 3 .   ? 133.290 126.887 129.357 1.00 20.00  ? 406 CLR A C17 1 
HETATM 4690 C C18 . CLR H 3 .   ? 132.675 128.547 131.083 1.00 20.00  ? 406 CLR A C18 1 
HETATM 4691 C C19 . CLR H 3 .   ? 132.701 128.218 135.199 1.00 20.00  ? 406 CLR A C19 1 
HETATM 4692 C C20 . CLR H 3 .   ? 132.337 127.592 128.403 1.00 20.00  ? 406 CLR A C20 1 
HETATM 4693 C C21 . CLR H 3 .   ? 130.901 127.134 128.597 1.00 20.00  ? 406 CLR A C21 1 
HETATM 4694 C C22 . CLR H 3 .   ? 132.776 127.358 126.967 1.00 20.00  ? 406 CLR A C22 1 
HETATM 4695 C C23 . CLR H 3 .   ? 133.248 128.658 126.341 1.00 20.00  ? 406 CLR A C23 1 
HETATM 4696 C C24 . CLR H 3 .   ? 133.868 128.392 124.979 1.00 20.00  ? 406 CLR A C24 1 
HETATM 4697 C C25 . CLR H 3 .   ? 132.912 128.805 123.874 1.00 20.00  ? 406 CLR A C25 1 
HETATM 4698 C C26 . CLR H 3 .   ? 132.935 130.312 123.677 1.00 20.00  ? 406 CLR A C26 1 
HETATM 4699 C C27 . CLR H 3 .   ? 133.252 128.087 122.578 1.00 20.00  ? 406 CLR A C27 1 
HETATM 4700 O O1  . CLR H 3 .   ? 133.955 126.091 139.294 1.00 20.00  ? 406 CLR A O1  1 
HETATM 4701 C C1  . CLR I 3 .   ? 125.552 126.224 106.929 1.00 20.00  ? 407 CLR A C1  1 
HETATM 4702 C C2  . CLR I 3 .   ? 125.640 126.268 105.401 1.00 20.00  ? 407 CLR A C2  1 
HETATM 4703 C C3  . CLR I 3 .   ? 125.012 127.564 104.886 1.00 20.00  ? 407 CLR A C3  1 
HETATM 4704 C C4  . CLR I 3 .   ? 125.817 128.761 105.398 1.00 20.00  ? 407 CLR A C4  1 
HETATM 4705 C C5  . CLR I 3 .   ? 125.895 128.672 106.913 1.00 20.00  ? 407 CLR A C5  1 
HETATM 4706 C C6  . CLR I 3 .   ? 125.555 129.718 107.609 1.00 20.00  ? 407 CLR A C6  1 
HETATM 4707 C C7  . CLR I 3 .   ? 125.585 129.746 109.109 1.00 20.00  ? 407 CLR A C7  1 
HETATM 4708 C C8  . CLR I 3 .   ? 126.624 128.739 109.612 1.00 20.00  ? 407 CLR A C8  1 
HETATM 4709 C C9  . CLR I 3 .   ? 126.299 127.354 109.035 1.00 20.00  ? 407 CLR A C9  1 
HETATM 4710 C C10 . CLR I 3 .   ? 126.362 127.383 107.517 1.00 20.00  ? 407 CLR A C10 1 
HETATM 4711 C C11 . CLR I 3 .   ? 127.226 126.265 109.570 1.00 20.00  ? 407 CLR A C11 1 
HETATM 4712 C C12 . CLR I 3 .   ? 127.258 126.248 111.105 1.00 20.00  ? 407 CLR A C12 1 
HETATM 4713 C C13 . CLR I 3 .   ? 127.641 127.645 111.594 1.00 20.00  ? 407 CLR A C13 1 
HETATM 4714 C C14 . CLR I 3 .   ? 126.542 128.635 111.123 1.00 20.00  ? 407 CLR A C14 1 
HETATM 4715 C C15 . CLR I 3 .   ? 126.910 129.904 111.900 1.00 20.00  ? 407 CLR A C15 1 
HETATM 4716 C C16 . CLR I 3 .   ? 127.282 129.357 113.305 1.00 20.00  ? 407 CLR A C16 1 
HETATM 4717 C C17 . CLR I 3 .   ? 127.698 127.878 113.101 1.00 20.00  ? 407 CLR A C17 1 
HETATM 4718 C C18 . CLR I 3 .   ? 128.955 128.080 110.946 1.00 20.00  ? 407 CLR A C18 1 
HETATM 4719 C C19 . CLR I 3 .   ? 127.829 127.180 107.133 1.00 20.00  ? 407 CLR A C19 1 
HETATM 4720 C C20 . CLR I 3 .   ? 129.119 127.654 113.619 1.00 20.00  ? 407 CLR A C20 1 
HETATM 4721 C C21 . CLR I 3 .   ? 129.537 126.206 113.349 1.00 20.00  ? 407 CLR A C21 1 
HETATM 4722 C C22 . CLR I 3 .   ? 129.163 127.923 115.124 1.00 20.00  ? 407 CLR A C22 1 
HETATM 4723 C C23 . CLR I 3 .   ? 130.584 127.698 115.642 1.00 20.00  ? 407 CLR A C23 1 
HETATM 4724 C C24 . CLR I 3 .   ? 130.628 127.968 117.148 1.00 20.00  ? 407 CLR A C24 1 
HETATM 4725 C C25 . CLR I 3 .   ? 132.049 127.743 117.667 1.00 20.00  ? 407 CLR A C25 1 
HETATM 4726 C C26 . CLR I 3 .   ? 132.093 128.012 119.171 1.00 20.00  ? 407 CLR A C26 1 
HETATM 4727 C C27 . CLR I 3 .   ? 132.466 126.296 117.396 1.00 20.00  ? 407 CLR A C27 1 
HETATM 4728 O O1  . CLR I 3 .   ? 125.020 127.560 103.456 1.00 20.00  ? 407 CLR A O1  1 
HETATM 4729 C C1  . CLR J 3 .   ? 104.271 110.036 135.842 1.00 20.00  ? 401 CLR B C1  1 
HETATM 4730 C C2  . CLR J 3 .   ? 103.664 110.529 137.159 1.00 20.00  ? 401 CLR B C2  1 
HETATM 4731 C C3  . CLR J 3 .   ? 104.467 111.721 137.682 1.00 20.00  ? 401 CLR B C3  1 
HETATM 4732 C C4  . CLR J 3 .   ? 104.355 112.885 136.694 1.00 20.00  ? 401 CLR B C4  1 
HETATM 4733 C C5  . CLR J 3 .   ? 104.798 112.396 135.325 1.00 20.00  ? 401 CLR B C5  1 
HETATM 4734 C C6  . CLR J 3 .   ? 105.696 113.086 134.686 1.00 20.00  ? 401 CLR B C6  1 
HETATM 4735 C C7  . CLR J 3 .   ? 106.215 112.698 133.333 1.00 20.00  ? 401 CLR B C7  1 
HETATM 4736 C C8  . CLR J 3 .   ? 105.149 111.877 132.600 1.00 20.00  ? 401 CLR B C8  1 
HETATM 4737 C C9  . CLR J 3 .   ? 104.756 110.676 133.470 1.00 20.00  ? 401 CLR B C9  1 
HETATM 4738 C C10 . CLR J 3 .   ? 104.169 111.145 134.791 1.00 20.00  ? 401 CLR B C10 1 
HETATM 4739 C C11 . CLR J 3 .   ? 103.771 109.743 132.770 1.00 20.00  ? 401 CLR B C11 1 
HETATM 4740 C C12 . CLR J 3 .   ? 104.285 109.303 131.391 1.00 20.00  ? 401 CLR B C12 1 
HETATM 4741 C C13 . CLR J 3 .   ? 104.601 110.555 130.573 1.00 20.00  ? 401 CLR B C13 1 
HETATM 4742 C C14 . CLR J 3 .   ? 105.725 111.336 131.305 1.00 20.00  ? 401 CLR B C14 1 
HETATM 4743 C C15 . CLR J 3 .   ? 106.112 112.384 130.256 1.00 20.00  ? 401 CLR B C15 1 
HETATM 4744 C C16 . CLR J 3 .   ? 106.104 111.573 128.933 1.00 20.00  ? 401 CLR B C16 1 
HETATM 4745 C C17 . CLR J 3 .   ? 105.167 110.361 129.169 1.00 20.00  ? 401 CLR B C17 1 
HETATM 4746 C C18 . CLR J 3 .   ? 103.373 111.464 130.521 1.00 20.00  ? 401 CLR B C18 1 
HETATM 4747 C C19 . CLR J 3 .   ? 102.686 111.425 134.539 1.00 20.00  ? 401 CLR B C19 1 
HETATM 4748 C C20 . CLR J 3 .   ? 104.039 110.357 128.137 1.00 20.00  ? 401 CLR B C20 1 
HETATM 4749 C C21 . CLR J 3 .   ? 103.089 109.193 128.427 1.00 20.00  ? 401 CLR B C21 1 
HETATM 4750 C C22 . CLR J 3 .   ? 104.630 110.194 126.735 1.00 20.00  ? 401 CLR B C22 1 
HETATM 4751 C C23 . CLR J 3 .   ? 103.501 110.189 125.703 1.00 20.00  ? 401 CLR B C23 1 
HETATM 4752 C C24 . CLR J 3 .   ? 104.092 110.027 124.301 1.00 20.00  ? 401 CLR B C24 1 
HETATM 4753 C C25 . CLR J 3 .   ? 102.964 110.021 123.268 1.00 20.00  ? 401 CLR B C25 1 
HETATM 4754 C C26 . CLR J 3 .   ? 103.554 109.859 121.867 1.00 20.00  ? 401 CLR B C26 1 
HETATM 4755 C C27 . CLR J 3 .   ? 102.013 108.858 123.559 1.00 20.00  ? 401 CLR B C27 1 
HETATM 4756 O O1  . CLR J 3 .   ? 103.949 112.122 138.953 1.00 20.00  ? 401 CLR B O1  1 
HETATM 4757 C C1  . CLR K 3 .   ? 111.735 111.320 107.539 1.00 20.00  ? 402 CLR B C1  1 
HETATM 4758 C C2  . CLR K 3 .   ? 112.093 111.129 106.074 1.00 20.00  ? 402 CLR B C2  1 
HETATM 4759 C C3  . CLR K 3 .   ? 113.497 110.561 105.958 1.00 20.00  ? 402 CLR B C3  1 
HETATM 4760 C C4  . CLR K 3 .   ? 113.535 109.185 106.604 1.00 20.00  ? 402 CLR B C4  1 
HETATM 4761 C C5  . CLR K 3 .   ? 112.976 109.235 108.005 1.00 20.00  ? 402 CLR B C5  1 
HETATM 4762 C C6  . CLR K 3 .   ? 113.650 108.569 108.955 1.00 20.00  ? 402 CLR B C6  1 
HETATM 4763 C C7  . CLR K 3 .   ? 113.206 108.503 110.395 1.00 20.00  ? 402 CLR B C7  1 
HETATM 4764 C C8  . CLR K 3 .   ? 111.796 108.998 110.571 1.00 20.00  ? 402 CLR B C8  1 
HETATM 4765 C C9  . CLR K 3 .   ? 111.560 110.269 109.778 1.00 20.00  ? 402 CLR B C9  1 
HETATM 4766 C C10 . CLR K 3 .   ? 111.703 109.995 108.285 1.00 20.00  ? 402 CLR B C10 1 
HETATM 4767 C C11 . CLR K 3 .   ? 110.213 110.925 110.117 1.00 20.00  ? 402 CLR B C11 1 
HETATM 4768 C C12 . CLR K 3 .   ? 109.966 111.079 111.620 1.00 20.00  ? 402 CLR B C12 1 
HETATM 4769 C C13 . CLR K 3 .   ? 110.163 109.760 112.331 1.00 20.00  ? 402 CLR B C13 1 
HETATM 4770 C C14 . CLR K 3 .   ? 111.567 109.294 112.033 1.00 20.00  ? 402 CLR B C14 1 
HETATM 4771 C C15 . CLR K 3 .   ? 111.807 108.137 112.991 1.00 20.00  ? 402 CLR B C15 1 
HETATM 4772 C C16 . CLR K 3 .   ? 110.981 108.508 114.219 1.00 20.00  ? 402 CLR B C16 1 
HETATM 4773 C C17 . CLR K 3 .   ? 110.174 109.753 113.851 1.00 20.00  ? 402 CLR B C17 1 
HETATM 4774 C C18 . CLR K 3 .   ? 109.120 108.758 111.839 1.00 20.00  ? 402 CLR B C18 1 
HETATM 4775 C C19 . CLR K 3 .   ? 110.550 109.153 107.754 1.00 20.00  ? 402 CLR B C19 1 
HETATM 4776 C C20 . CLR K 3 .   ? 108.817 109.762 114.542 1.00 20.00  ? 402 CLR B C20 1 
HETATM 4777 C C21 . CLR K 3 .   ? 107.960 110.936 114.101 1.00 20.00  ? 402 CLR B C21 1 
HETATM 4778 C C22 . CLR K 3 .   ? 108.981 109.808 116.054 1.00 20.00  ? 402 CLR B C22 1 
HETATM 4779 C C23 . CLR K 3 .   ? 107.854 109.049 116.737 1.00 20.00  ? 402 CLR B C23 1 
HETATM 4780 C C24 . CLR K 3 .   ? 107.816 109.369 118.225 1.00 20.00  ? 402 CLR B C24 1 
HETATM 4781 C C25 . CLR K 3 .   ? 107.303 108.179 119.023 1.00 20.00  ? 402 CLR B C25 1 
HETATM 4782 C C26 . CLR K 3 .   ? 107.900 108.147 120.422 1.00 20.00  ? 402 CLR B C26 1 
HETATM 4783 C C27 . CLR K 3 .   ? 105.785 108.205 119.097 1.00 20.00  ? 402 CLR B C27 1 
HETATM 4784 O O1  . CLR K 3 .   ? 113.867 110.446 104.581 1.00 20.00  ? 402 CLR B O1  1 
HETATM 4785 C C   . MW9 L 2 .   ? 117.856 143.262 124.994 1.00 57.68  ? 403 MW9 B C   1 
HETATM 4786 O O   . MW9 L 2 .   ? 122.177 146.010 138.159 1.00 57.68  ? 403 MW9 B O   1 
HETATM 4787 C C1  . MW9 L 2 .   ? 119.368 143.296 125.309 1.00 57.68  ? 403 MW9 B C1  1 
HETATM 4788 C C10 . MW9 L 2 .   ? 123.836 146.288 130.278 1.00 57.68  ? 403 MW9 B C10 1 
HETATM 4789 C C11 . MW9 L 2 .   ? 124.289 147.216 131.430 1.00 57.68  ? 403 MW9 B C11 1 
HETATM 4790 C C12 . MW9 L 2 .   ? 123.512 146.855 132.724 1.00 57.68  ? 403 MW9 B C12 1 
HETATM 4791 C C13 . MW9 L 2 .   ? 122.986 148.154 133.395 1.00 57.68  ? 403 MW9 B C13 1 
HETATM 4792 C C14 . MW9 L 2 .   ? 122.660 147.866 134.884 1.00 57.68  ? 403 MW9 B C14 1 
HETATM 4793 C C15 . MW9 L 2 .   ? 123.973 147.545 135.644 1.00 57.68  ? 403 MW9 B C15 1 
HETATM 4794 C C16 . MW9 L 2 .   ? 123.705 147.540 137.171 1.00 57.68  ? 403 MW9 B C16 1 
HETATM 4795 C C17 . MW9 L 2 .   ? 123.226 146.135 137.610 1.00 57.68  ? 403 MW9 B C17 1 
HETATM 4796 C C18 . MW9 L 2 .   ? 123.448 144.071 136.461 1.00 57.68  ? 403 MW9 B C18 1 
HETATM 4797 C C19 . MW9 L 2 .   ? 124.269 142.775 136.441 1.00 57.68  ? 403 MW9 B C19 1 
HETATM 4798 C C2  . MW9 L 2 .   ? 119.963 144.646 124.848 1.00 57.68  ? 403 MW9 B C2  1 
HETATM 4799 C C20 . MW9 L 2 .   ? 124.837 142.509 137.843 1.00 57.68  ? 403 MW9 B C20 1 
HETATM 4800 C C21 . MW9 L 2 .   ? 124.279 140.872 142.218 1.00 57.68  ? 403 MW9 B C21 1 
HETATM 4801 C C22 . MW9 L 2 .   ? 124.465 139.561 142.991 1.00 57.68  ? 403 MW9 B C22 1 
HETATM 4802 C C23 . MW9 L 2 .   ? 123.461 139.500 144.150 1.00 57.68  ? 403 MW9 B C23 1 
HETATM 4803 C C24 . MW9 L 2 .   ? 125.296 141.967 134.472 1.00 57.68  ? 403 MW9 B C24 1 
HETATM 4804 C C25 . MW9 L 2 .   ? 123.953 141.496 133.860 1.00 57.68  ? 403 MW9 B C25 1 
HETATM 4805 C C26 . MW9 L 2 .   ? 123.481 142.511 132.790 1.00 57.68  ? 403 MW9 B C26 1 
HETATM 4806 C C27 . MW9 L 2 .   ? 124.379 142.399 131.531 1.00 57.68  ? 403 MW9 B C27 1 
HETATM 4807 C C28 . MW9 L 2 .   ? 123.784 141.347 130.555 1.00 57.68  ? 403 MW9 B C28 1 
HETATM 4808 C C29 . MW9 L 2 .   ? 123.954 141.854 129.098 1.00 57.68  ? 403 MW9 B C29 1 
HETATM 4809 C C3  . MW9 L 2 .   ? 121.220 144.968 125.696 1.00 57.68  ? 403 MW9 B C3  1 
HETATM 4810 C C30 . MW9 L 2 .   ? 122.759 141.360 128.238 1.00 57.68  ? 403 MW9 B C30 1 
HETATM 4811 C C31 . MW9 L 2 .   ? 123.286 140.838 126.875 1.00 57.68  ? 403 MW9 B C31 1 
HETATM 4812 C C32 . MW9 L 2 .   ? 122.323 141.301 125.752 1.00 57.68  ? 403 MW9 B C32 1 
HETATM 4813 C C33 . MW9 L 2 .   ? 122.540 140.696 124.582 1.00 57.68  ? 403 MW9 B C33 1 
HETATM 4814 C C34 . MW9 L 2 .   ? 123.272 139.711 123.642 1.00 57.68  ? 403 MW9 B C34 1 
HETATM 4815 C C35 . MW9 L 2 .   ? 123.473 138.345 124.335 1.00 57.68  ? 403 MW9 B C35 1 
HETATM 4816 C C36 . MW9 L 2 .   ? 124.664 137.587 123.697 1.00 57.68  ? 403 MW9 B C36 1 
HETATM 4817 C C37 . MW9 L 2 .   ? 125.768 138.580 123.255 1.00 57.68  ? 403 MW9 B C37 1 
HETATM 4818 C C38 . MW9 L 2 .   ? 126.290 138.182 121.853 1.00 57.68  ? 403 MW9 B C38 1 
HETATM 4819 C C39 . MW9 L 2 .   ? 126.677 139.457 121.063 1.00 57.68  ? 403 MW9 B C39 1 
HETATM 4820 C C4  . MW9 L 2 .   ? 121.634 146.446 125.474 1.00 57.68  ? 403 MW9 B C4  1 
HETATM 4821 C C40 . MW9 L 2 .   ? 125.397 140.215 120.641 1.00 57.68  ? 403 MW9 B C40 1 
HETATM 4822 C C41 . MW9 L 2 .   ? 124.540 139.313 119.727 1.00 57.68  ? 403 MW9 B C41 1 
HETATM 4823 C C5  . MW9 L 2 .   ? 123.166 146.529 125.258 1.00 57.68  ? 403 MW9 B C5  1 
HETATM 4824 C C6  . MW9 L 2 .   ? 123.742 147.677 126.124 1.00 57.68  ? 403 MW9 B C6  1 
HETATM 4825 C C7  . MW9 L 2 .   ? 125.122 147.252 126.690 1.00 57.68  ? 403 MW9 B C7  1 
HETATM 4826 C C8  . MW9 L 2 .   ? 124.921 146.541 128.045 1.00 57.68  ? 403 MW9 B C8  1 
HETATM 4827 C C9  . MW9 L 2 .   ? 124.031 147.008 128.924 1.00 57.68  ? 403 MW9 B C9  1 
HETATM 4828 O O1  . MW9 L 2 .   ? 124.034 144.996 137.362 1.00 57.68  ? 403 MW9 B O1  1 
HETATM 4829 O O2  . MW9 L 2 .   ? 124.533 141.181 138.232 1.00 57.68  ? 403 MW9 B O2  1 
HETATM 4830 O O3  . MW9 L 2 .   ? 122.813 139.714 139.500 1.00 57.68  ? 403 MW9 B O3  1 
HETATM 4831 O O4  . MW9 L 2 .   ? 122.822 142.136 139.935 1.00 57.68  ? 403 MW9 B O4  1 
HETATM 4832 O O5  . MW9 L 2 .   ? 124.755 140.710 140.896 1.00 57.68  ? 403 MW9 B O5  1 
HETATM 4833 O O6  . MW9 L 2 .   ? 122.424 140.421 143.920 1.00 57.68  ? 403 MW9 B O6  1 
HETATM 4834 O O7  . MW9 L 2 .   ? 125.763 139.500 143.498 1.00 57.68  ? 403 MW9 B O7  1 
HETATM 4835 O O8  . MW9 L 2 .   ? 125.314 142.912 135.525 1.00 57.68  ? 403 MW9 B O8  1 
HETATM 4836 O O9  . MW9 L 2 .   ? 126.317 141.532 134.055 1.00 57.68  ? 403 MW9 B O9  1 
HETATM 4837 P P   . MW9 L 2 .   ? 123.690 140.936 139.643 1.00 57.68  ? 403 MW9 B P   1 
HETATM 4838 C C   . MW9 M 2 .   ? 116.862 123.836 121.521 1.00 46.00  ? 404 MW9 B C   1 
HETATM 4839 O O   . MW9 M 2 .   ? 109.770 122.726 136.139 1.00 46.00  ? 404 MW9 B O   1 
HETATM 4840 C C1  . MW9 M 2 .   ? 115.432 123.653 122.074 1.00 46.00  ? 404 MW9 B C1  1 
HETATM 4841 C C10 . MW9 M 2 .   ? 110.591 126.052 128.013 1.00 46.00  ? 404 MW9 B C10 1 
HETATM 4842 C C11 . MW9 M 2 .   ? 109.550 124.934 127.771 1.00 46.00  ? 404 MW9 B C11 1 
HETATM 4843 C C12 . MW9 M 2 .   ? 108.822 124.592 129.098 1.00 46.00  ? 404 MW9 B C12 1 
HETATM 4844 C C13 . MW9 M 2 .   ? 109.866 124.290 130.206 1.00 46.00  ? 404 MW9 B C13 1 
HETATM 4845 C C14 . MW9 M 2 .   ? 109.158 123.567 131.378 1.00 46.00  ? 404 MW9 B C14 1 
HETATM 4846 C C15 . MW9 M 2 .   ? 109.962 123.771 132.687 1.00 46.00  ? 404 MW9 B C15 1 
HETATM 4847 C C16 . MW9 M 2 .   ? 109.322 122.922 133.816 1.00 46.00  ? 404 MW9 B C16 1 
HETATM 4848 C C17 . MW9 M 2 .   ? 109.794 123.443 135.192 1.00 46.00  ? 404 MW9 B C17 1 
HETATM 4849 C C18 . MW9 M 2 .   ? 111.394 124.902 136.151 1.00 46.00  ? 404 MW9 B C18 1 
HETATM 4850 C C19 . MW9 M 2 .   ? 112.467 125.680 135.382 1.00 46.00  ? 404 MW9 B C19 1 
HETATM 4851 C C2  . MW9 M 2 .   ? 114.477 124.638 121.366 1.00 46.00  ? 404 MW9 B C2  1 
HETATM 4852 C C20 . MW9 M 2 .   ? 113.815 124.953 135.492 1.00 46.00  ? 404 MW9 B C20 1 
HETATM 4853 C C21 . MW9 M 2 .   ? 116.381 124.564 140.045 1.00 46.00  ? 404 MW9 B C21 1 
HETATM 4854 C C22 . MW9 M 2 .   ? 116.556 123.424 141.056 1.00 46.00  ? 404 MW9 B C22 1 
HETATM 4855 C C23 . MW9 M 2 .   ? 115.279 122.574 141.102 1.00 46.00  ? 404 MW9 B C23 1 
HETATM 4856 C C24 . MW9 M 2 .   ? 112.015 127.981 135.104 1.00 46.00  ? 404 MW9 B C24 1 
HETATM 4857 C C25 . MW9 M 2 .   ? 112.913 128.932 134.267 1.00 46.00  ? 404 MW9 B C25 1 
HETATM 4858 C C26 . MW9 M 2 .   ? 113.631 128.136 133.145 1.00 46.00  ? 404 MW9 B C26 1 
HETATM 4859 C C27 . MW9 M 2 .   ? 113.025 128.489 131.762 1.00 46.00  ? 404 MW9 B C27 1 
HETATM 4860 C C28 . MW9 M 2 .   ? 113.284 129.987 131.440 1.00 46.00  ? 404 MW9 B C28 1 
HETATM 4861 C C29 . MW9 M 2 .   ? 114.550 130.111 130.552 1.00 46.00  ? 404 MW9 B C29 1 
HETATM 4862 C C3  . MW9 M 2 .   ? 114.046 125.746 122.359 1.00 46.00  ? 404 MW9 B C3  1 
HETATM 4863 C C30 . MW9 M 2 .   ? 114.129 130.200 129.063 1.00 46.00  ? 404 MW9 B C30 1 
HETATM 4864 C C31 . MW9 M 2 .   ? 114.222 128.795 128.410 1.00 46.00  ? 404 MW9 B C31 1 
HETATM 4865 C C32 . MW9 M 2 .   ? 114.891 128.899 127.017 1.00 46.00  ? 404 MW9 B C32 1 
HETATM 4866 C C33 . MW9 M 2 .   ? 114.547 130.014 126.377 1.00 46.00  ? 404 MW9 B C33 1 
HETATM 4867 C C34 . MW9 M 2 .   ? 114.592 130.977 125.175 1.00 46.00  ? 404 MW9 B C34 1 
HETATM 4868 C C35 . MW9 M 2 .   ? 114.581 130.176 123.861 1.00 46.00  ? 404 MW9 B C35 1 
HETATM 4869 C C36 . MW9 M 2 .   ? 114.709 131.172 122.686 1.00 46.00  ? 404 MW9 B C36 1 
HETATM 4870 C C37 . MW9 M 2 .   ? 113.306 131.454 122.097 1.00 46.00  ? 404 MW9 B C37 1 
HETATM 4871 C C38 . MW9 M 2 .   ? 113.454 132.060 120.683 1.00 46.00  ? 404 MW9 B C38 1 
HETATM 4872 C C39 . MW9 M 2 .   ? 112.087 132.014 119.961 1.00 46.00  ? 404 MW9 B C39 1 
HETATM 4873 C C4  . MW9 M 2 .   ? 113.481 125.087 123.644 1.00 46.00  ? 404 MW9 B C4  1 
HETATM 4874 C C40 . MW9 M 2 .   ? 112.175 132.786 118.624 1.00 46.00  ? 404 MW9 B C40 1 
HETATM 4875 C C41 . MW9 M 2 .   ? 112.557 131.814 117.488 1.00 46.00  ? 404 MW9 B C41 1 
HETATM 4876 C C5  . MW9 M 2 .   ? 111.965 125.387 123.762 1.00 46.00  ? 404 MW9 B C5  1 
HETATM 4877 C C6  . MW9 M 2 .   ? 111.711 126.899 123.544 1.00 46.00  ? 404 MW9 B C6  1 
HETATM 4878 C C7  . MW9 M 2 .   ? 110.432 127.336 124.302 1.00 46.00  ? 404 MW9 B C7  1 
HETATM 4879 C C8  . MW9 M 2 .   ? 110.250 126.480 125.574 1.00 46.00  ? 404 MW9 B C8  1 
HETATM 4880 C C9  . MW9 M 2 .   ? 110.764 126.896 126.731 1.00 46.00  ? 404 MW9 B C9  1 
HETATM 4881 O O1  . MW9 M 2 .   ? 110.249 124.775 135.332 1.00 46.00  ? 404 MW9 B O1  1 
HETATM 4882 O O2  . MW9 M 2 .   ? 113.983 124.487 136.817 1.00 46.00  ? 404 MW9 B O2  1 
HETATM 4883 O O3  . MW9 M 2 .   ? 116.566 124.620 136.894 1.00 46.00  ? 404 MW9 B O3  1 
HETATM 4884 O O4  . MW9 M 2 .   ? 115.273 126.484 137.861 1.00 46.00  ? 404 MW9 B O4  1 
HETATM 4885 O O5  . MW9 M 2 .   ? 115.338 124.242 139.147 1.00 46.00  ? 404 MW9 B O5  1 
HETATM 4886 O O6  . MW9 M 2 .   ? 115.011 122.061 139.819 1.00 46.00  ? 404 MW9 B O6  1 
HETATM 4887 O O7  . MW9 M 2 .   ? 116.806 123.958 142.322 1.00 46.00  ? 404 MW9 B O7  1 
HETATM 4888 O O8  . MW9 M 2 .   ? 112.591 126.968 135.909 1.00 46.00  ? 404 MW9 B O8  1 
HETATM 4889 O O9  . MW9 M 2 .   ? 110.835 128.106 135.073 1.00 46.00  ? 404 MW9 B O9  1 
HETATM 4890 P P   . MW9 M 2 .   ? 115.320 124.988 137.666 1.00 46.00  ? 404 MW9 B P   1 
HETATM 4891 C C1  . CLR N 3 .   ? 129.825 135.918 134.239 1.00 20.00  ? 405 CLR B C1  1 
HETATM 4892 C C2  . CLR N 3 .   ? 130.491 135.608 135.582 1.00 20.00  ? 405 CLR B C2  1 
HETATM 4893 C C3  . CLR N 3 .   ? 129.551 134.757 136.438 1.00 20.00  ? 405 CLR B C3  1 
HETATM 4894 C C4  . CLR N 3 .   ? 129.316 133.409 135.753 1.00 20.00  ? 405 CLR B C4  1 
HETATM 4895 C C5  . CLR N 3 .   ? 128.802 133.669 134.347 1.00 20.00  ? 405 CLR B C5  1 
HETATM 4896 C C6  . CLR N 3 .   ? 127.716 133.063 133.966 1.00 20.00  ? 405 CLR B C6  1 
HETATM 4897 C C7  . CLR N 3 .   ? 127.111 133.248 132.606 1.00 20.00  ? 405 CLR B C7  1 
HETATM 4898 C C8  . CLR N 3 .   ? 128.211 133.642 131.615 1.00 20.00  ? 405 CLR B C8  1 
HETATM 4899 C C9  . CLR N 3 .   ? 128.930 134.893 132.136 1.00 20.00  ? 405 CLR B C9  1 
HETATM 4900 C C10 . CLR N 3 .   ? 129.581 134.610 133.480 1.00 20.00  ? 405 CLR B C10 1 
HETATM 4901 C C11 . CLR N 3 .   ? 129.975 135.419 131.156 1.00 20.00  ? 405 CLR B C11 1 
HETATM 4902 C C12 . CLR N 3 .   ? 129.382 135.646 129.757 1.00 20.00  ? 405 CLR B C12 1 
HETATM 4903 C C13 . CLR N 3 .   ? 128.735 134.342 129.291 1.00 20.00  ? 405 CLR B C13 1 
HETATM 4904 C C14 . CLR N 3 .   ? 127.587 133.997 130.278 1.00 20.00  ? 405 CLR B C14 1 
HETATM 4905 C C15 . CLR N 3 .   ? 126.879 132.851 129.546 1.00 20.00  ? 405 CLR B C15 1 
HETATM 4906 C C16 . CLR N 3 .   ? 126.870 133.333 128.070 1.00 20.00  ? 405 CLR B C16 1 
HETATM 4907 C C17 . CLR N 3 .   ? 128.040 134.340 127.933 1.00 20.00  ? 405 CLR B C17 1 
HETATM 4908 C C18 . CLR N 3 .   ? 129.753 133.203 129.361 1.00 20.00  ? 405 CLR B C18 1 
HETATM 4909 C C19 . CLR N 3 .   ? 130.941 133.973 133.184 1.00 20.00  ? 405 CLR B C19 1 
HETATM 4910 C C20 . CLR N 3 .   ? 129.008 133.878 126.843 1.00 20.00  ? 405 CLR B C20 1 
HETATM 4911 C C21 . CLR N 3 .   ? 130.190 134.848 126.768 1.00 20.00  ? 405 CLR B C21 1 
HETATM 4912 C C22 . CLR N 3 .   ? 128.285 133.852 125.495 1.00 20.00  ? 405 CLR B C22 1 
HETATM 4913 C C23 . CLR N 3 .   ? 129.254 133.392 124.405 1.00 20.00  ? 405 CLR B C23 1 
HETATM 4914 C C24 . CLR N 3 .   ? 128.530 133.365 123.057 1.00 20.00  ? 405 CLR B C24 1 
HETATM 4915 C C25 . CLR N 3 .   ? 129.498 132.904 121.966 1.00 20.00  ? 405 CLR B C25 1 
HETATM 4916 C C26 . CLR N 3 .   ? 128.775 132.878 120.618 1.00 20.00  ? 405 CLR B C26 1 
HETATM 4917 C C27 . CLR N 3 .   ? 130.680 133.874 121.891 1.00 20.00  ? 405 CLR B C27 1 
HETATM 4918 O O1  . CLR N 3 .   ? 130.143 134.543 137.723 1.00 20.00  ? 405 CLR B O1  1 
HETATM 4919 C C1  . CLR O 3 .   ? 122.370 142.395 107.759 1.00 20.00  ? 406 CLR B C1  1 
HETATM 4920 C C2  . CLR O 3 .   ? 121.636 142.180 106.432 1.00 20.00  ? 406 CLR B C2  1 
HETATM 4921 C C3  . CLR O 3 .   ? 121.859 140.746 105.948 1.00 20.00  ? 406 CLR B C3  1 
HETATM 4922 C C4  . CLR O 3 .   ? 121.238 139.767 106.948 1.00 20.00  ? 406 CLR B C4  1 
HETATM 4923 C C5  . CLR O 3 .   ? 121.821 140.051 108.322 1.00 20.00  ? 406 CLR B C5  1 
HETATM 4924 C C6  . CLR O 3 .   ? 122.323 139.058 108.995 1.00 20.00  ? 406 CLR B C6  1 
HETATM 4925 C C7  . CLR O 3 .   ? 122.932 139.218 110.357 1.00 20.00  ? 406 CLR B C7  1 
HETATM 4926 C C8  . CLR O 3 .   ? 122.307 140.434 111.049 1.00 20.00  ? 406 CLR B C8  1 
HETATM 4927 C C9  . CLR O 3 .   ? 122.486 141.666 110.152 1.00 20.00  ? 406 CLR B C9  1 
HETATM 4928 C C10 . CLR O 3 .   ? 121.780 141.463 108.822 1.00 20.00  ? 406 CLR B C10 1 
HETATM 4929 C C11 . CLR O 3 .   ? 121.984 142.949 110.812 1.00 20.00  ? 406 CLR B C11 1 
HETATM 4930 C C12 . CLR O 3 .   ? 122.609 143.159 112.199 1.00 20.00  ? 406 CLR B C12 1 
HETATM 4931 C C13 . CLR O 3 .   ? 122.340 141.912 113.042 1.00 20.00  ? 406 CLR B C13 1 
HETATM 4932 C C14 . CLR O 3 .   ? 123.034 140.707 112.352 1.00 20.00  ? 406 CLR B C14 1 
HETATM 4933 C C15 . CLR O 3 .   ? 122.912 139.619 113.425 1.00 20.00  ? 406 CLR B C15 1 
HETATM 4934 C C16 . CLR O 3 .   ? 123.227 140.387 114.737 1.00 20.00  ? 406 CLR B C16 1 
HETATM 4935 C C17 . CLR O 3 .   ? 122.907 141.878 114.459 1.00 20.00  ? 406 CLR B C17 1 
HETATM 4936 C C18 . CLR O 3 .   ? 120.840 141.620 113.071 1.00 20.00  ? 406 CLR B C18 1 
HETATM 4937 C C19 . CLR O 3 .   ? 120.316 141.853 109.036 1.00 20.00  ? 406 CLR B C19 1 
HETATM 4938 C C20 . CLR O 3 .   ? 121.870 142.390 115.458 1.00 20.00  ? 406 CLR B C20 1 
HETATM 4939 C C21 . CLR O 3 .   ? 121.518 143.842 115.126 1.00 20.00  ? 406 CLR B C21 1 
HETATM 4940 C C22 . CLR O 3 .   ? 122.445 142.318 116.874 1.00 20.00  ? 406 CLR B C22 1 
HETATM 4941 C C23 . CLR O 3 .   ? 121.409 142.832 117.873 1.00 20.00  ? 406 CLR B C23 1 
HETATM 4942 C C24 . CLR O 3 .   ? 121.984 142.758 119.290 1.00 20.00  ? 406 CLR B C24 1 
HETATM 4943 C C25 . CLR O 3 .   ? 120.947 143.272 120.290 1.00 20.00  ? 406 CLR B C25 1 
HETATM 4944 C C26 . CLR O 3 .   ? 121.522 143.199 121.705 1.00 20.00  ? 406 CLR B C26 1 
HETATM 4945 C C27 . CLR O 3 .   ? 120.595 144.723 119.957 1.00 20.00  ? 406 CLR B C27 1 
HETATM 4946 O O1  . CLR O 3 .   ? 121.244 140.576 104.669 1.00 20.00  ? 406 CLR B O1  1 
# 
