data_8YJG
# 
_entry.id   8YJG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YJG         pdb_00008yjg 10.2210/pdb8yjg/pdb 
WWPDB D_1300045782 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-05 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YJG 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              imyoungjun@jnu.ac.kr 
_pdbx_contact_author.name_first         'Young Jun' 
_pdbx_contact_author.name_last          Im 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3644-3028 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tan, L.'   1 ? 
'Li, X.'    2 ? 
'Zhang, G.' 3 ? 
'Chen, L.'  4 ? 
'Im, Y.J.'  5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of the nucleotide-binding domain of Candida glabrata Hsp90' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tan, L.'   1 ? 
primary 'Li, X.'    2 ? 
primary 'Zhang, G.' 3 ? 
primary 'Chen, L.'  4 ? 
primary 'Im, Y.J.'  5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'ATP-dependent molecular chaperone HSC82' 24386.791 1   ? ? ? 
;The nucleotide-binding domain of C.g. Hsp90. The N-terminal GSAMGS is a linker sequence for the N-terminal cleavable His-tag fusion originating from the plasmid.
;
2 water   nat water                                     18.015    176 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSAMGSSETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDAIDKIRYQALSDPKQLETEPELFIRITPRPEEKVLE
IRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNDDEQYIWESNAGGSF
TVTLDTVNEKIGRGTILRLFMKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLMVTKEV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSAMGSSETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDAIDKIRYQALSDPKQLETEPELFIRITPRPEEKVLE
IRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNDDEQYIWESNAGGSF
TVTLDTVNEKIGRGTILRLFMKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLMVTKEV
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   ALA n 
1 4   MET n 
1 5   GLY n 
1 6   SER n 
1 7   SER n 
1 8   GLU n 
1 9   THR n 
1 10  PHE n 
1 11  GLU n 
1 12  PHE n 
1 13  GLN n 
1 14  ALA n 
1 15  GLU n 
1 16  ILE n 
1 17  THR n 
1 18  GLN n 
1 19  LEU n 
1 20  MET n 
1 21  SER n 
1 22  LEU n 
1 23  ILE n 
1 24  ILE n 
1 25  ASN n 
1 26  THR n 
1 27  VAL n 
1 28  TYR n 
1 29  SER n 
1 30  ASN n 
1 31  LYS n 
1 32  GLU n 
1 33  ILE n 
1 34  PHE n 
1 35  LEU n 
1 36  ARG n 
1 37  GLU n 
1 38  LEU n 
1 39  ILE n 
1 40  SER n 
1 41  ASN n 
1 42  ALA n 
1 43  SER n 
1 44  ASP n 
1 45  ALA n 
1 46  ILE n 
1 47  ASP n 
1 48  LYS n 
1 49  ILE n 
1 50  ARG n 
1 51  TYR n 
1 52  GLN n 
1 53  ALA n 
1 54  LEU n 
1 55  SER n 
1 56  ASP n 
1 57  PRO n 
1 58  LYS n 
1 59  GLN n 
1 60  LEU n 
1 61  GLU n 
1 62  THR n 
1 63  GLU n 
1 64  PRO n 
1 65  GLU n 
1 66  LEU n 
1 67  PHE n 
1 68  ILE n 
1 69  ARG n 
1 70  ILE n 
1 71  THR n 
1 72  PRO n 
1 73  ARG n 
1 74  PRO n 
1 75  GLU n 
1 76  GLU n 
1 77  LYS n 
1 78  VAL n 
1 79  LEU n 
1 80  GLU n 
1 81  ILE n 
1 82  ARG n 
1 83  ASP n 
1 84  SER n 
1 85  GLY n 
1 86  ILE n 
1 87  GLY n 
1 88  MET n 
1 89  THR n 
1 90  LYS n 
1 91  ALA n 
1 92  GLU n 
1 93  LEU n 
1 94  ILE n 
1 95  ASN n 
1 96  ASN n 
1 97  LEU n 
1 98  GLY n 
1 99  THR n 
1 100 ILE n 
1 101 ALA n 
1 102 LYS n 
1 103 SER n 
1 104 GLY n 
1 105 THR n 
1 106 LYS n 
1 107 ALA n 
1 108 PHE n 
1 109 MET n 
1 110 GLU n 
1 111 ALA n 
1 112 LEU n 
1 113 SER n 
1 114 ALA n 
1 115 GLY n 
1 116 ALA n 
1 117 ASP n 
1 118 VAL n 
1 119 SER n 
1 120 MET n 
1 121 ILE n 
1 122 GLY n 
1 123 GLN n 
1 124 PHE n 
1 125 GLY n 
1 126 VAL n 
1 127 GLY n 
1 128 PHE n 
1 129 TYR n 
1 130 SER n 
1 131 LEU n 
1 132 PHE n 
1 133 LEU n 
1 134 VAL n 
1 135 ALA n 
1 136 ASP n 
1 137 ARG n 
1 138 VAL n 
1 139 GLN n 
1 140 VAL n 
1 141 ILE n 
1 142 SER n 
1 143 LYS n 
1 144 ASN n 
1 145 ASN n 
1 146 ASP n 
1 147 ASP n 
1 148 GLU n 
1 149 GLN n 
1 150 TYR n 
1 151 ILE n 
1 152 TRP n 
1 153 GLU n 
1 154 SER n 
1 155 ASN n 
1 156 ALA n 
1 157 GLY n 
1 158 GLY n 
1 159 SER n 
1 160 PHE n 
1 161 THR n 
1 162 VAL n 
1 163 THR n 
1 164 LEU n 
1 165 ASP n 
1 166 THR n 
1 167 VAL n 
1 168 ASN n 
1 169 GLU n 
1 170 LYS n 
1 171 ILE n 
1 172 GLY n 
1 173 ARG n 
1 174 GLY n 
1 175 THR n 
1 176 ILE n 
1 177 LEU n 
1 178 ARG n 
1 179 LEU n 
1 180 PHE n 
1 181 MET n 
1 182 LYS n 
1 183 GLU n 
1 184 ASP n 
1 185 GLN n 
1 186 LEU n 
1 187 GLU n 
1 188 TYR n 
1 189 LEU n 
1 190 GLU n 
1 191 GLU n 
1 192 LYS n 
1 193 ARG n 
1 194 ILE n 
1 195 LYS n 
1 196 GLU n 
1 197 VAL n 
1 198 VAL n 
1 199 LYS n 
1 200 LYS n 
1 201 HIS n 
1 202 SER n 
1 203 GLU n 
1 204 PHE n 
1 205 VAL n 
1 206 ALA n 
1 207 TYR n 
1 208 PRO n 
1 209 ILE n 
1 210 GLN n 
1 211 LEU n 
1 212 MET n 
1 213 VAL n 
1 214 THR n 
1 215 LYS n 
1 216 GLU n 
1 217 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   217 
_entity_src_gen.gene_src_common_name               'Nakaseomyces glabratus' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 hsp90 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Candida glabrata' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5478 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   'The N-terminal His-tag fusion cleavable by thrombin protease' 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pHIS2-thr 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -4  ?   ?   ?   A . n 
A 1 2   SER 2   -3  ?   ?   ?   A . n 
A 1 3   ALA 3   -2  ?   ?   ?   A . n 
A 1 4   MET 4   -1  ?   ?   ?   A . n 
A 1 5   GLY 5   0   ?   ?   ?   A . n 
A 1 6   SER 6   1   1   SER SER A . n 
A 1 7   SER 7   2   2   SER SER A . n 
A 1 8   GLU 8   3   3   GLU GLU A . n 
A 1 9   THR 9   4   4   THR THR A . n 
A 1 10  PHE 10  5   5   PHE PHE A . n 
A 1 11  GLU 11  6   6   GLU GLU A . n 
A 1 12  PHE 12  7   7   PHE PHE A . n 
A 1 13  GLN 13  8   8   GLN GLN A . n 
A 1 14  ALA 14  9   9   ALA ALA A . n 
A 1 15  GLU 15  10  10  GLU GLU A . n 
A 1 16  ILE 16  11  11  ILE ILE A . n 
A 1 17  THR 17  12  12  THR THR A . n 
A 1 18  GLN 18  13  13  GLN GLN A . n 
A 1 19  LEU 19  14  14  LEU LEU A . n 
A 1 20  MET 20  15  15  MET MET A . n 
A 1 21  SER 21  16  16  SER SER A . n 
A 1 22  LEU 22  17  17  LEU LEU A . n 
A 1 23  ILE 23  18  18  ILE ILE A . n 
A 1 24  ILE 24  19  19  ILE ILE A . n 
A 1 25  ASN 25  20  20  ASN ASN A . n 
A 1 26  THR 26  21  21  THR THR A . n 
A 1 27  VAL 27  22  22  VAL VAL A . n 
A 1 28  TYR 28  23  23  TYR TYR A . n 
A 1 29  SER 29  24  24  SER SER A . n 
A 1 30  ASN 30  25  25  ASN ASN A . n 
A 1 31  LYS 31  26  26  LYS LYS A . n 
A 1 32  GLU 32  27  27  GLU GLU A . n 
A 1 33  ILE 33  28  28  ILE ILE A . n 
A 1 34  PHE 34  29  29  PHE PHE A . n 
A 1 35  LEU 35  30  30  LEU LEU A . n 
A 1 36  ARG 36  31  31  ARG ARG A . n 
A 1 37  GLU 37  32  32  GLU GLU A . n 
A 1 38  LEU 38  33  33  LEU LEU A . n 
A 1 39  ILE 39  34  34  ILE ILE A . n 
A 1 40  SER 40  35  35  SER SER A . n 
A 1 41  ASN 41  36  36  ASN ASN A . n 
A 1 42  ALA 42  37  37  ALA ALA A . n 
A 1 43  SER 43  38  38  SER SER A . n 
A 1 44  ASP 44  39  39  ASP ASP A . n 
A 1 45  ALA 45  40  40  ALA ALA A . n 
A 1 46  ILE 46  41  41  ILE ILE A . n 
A 1 47  ASP 47  42  42  ASP ASP A . n 
A 1 48  LYS 48  43  43  LYS LYS A . n 
A 1 49  ILE 49  44  44  ILE ILE A . n 
A 1 50  ARG 50  45  45  ARG ARG A . n 
A 1 51  TYR 51  46  46  TYR TYR A . n 
A 1 52  GLN 52  47  47  GLN GLN A . n 
A 1 53  ALA 53  48  48  ALA ALA A . n 
A 1 54  LEU 54  49  49  LEU LEU A . n 
A 1 55  SER 55  50  50  SER SER A . n 
A 1 56  ASP 56  51  51  ASP ASP A . n 
A 1 57  PRO 57  52  52  PRO PRO A . n 
A 1 58  LYS 58  53  53  LYS LYS A . n 
A 1 59  GLN 59  54  54  GLN GLN A . n 
A 1 60  LEU 60  55  55  LEU LEU A . n 
A 1 61  GLU 61  56  56  GLU GLU A . n 
A 1 62  THR 62  57  57  THR THR A . n 
A 1 63  GLU 63  58  58  GLU GLU A . n 
A 1 64  PRO 64  59  59  PRO PRO A . n 
A 1 65  GLU 65  60  60  GLU GLU A . n 
A 1 66  LEU 66  61  61  LEU LEU A . n 
A 1 67  PHE 67  62  62  PHE PHE A . n 
A 1 68  ILE 68  63  63  ILE ILE A . n 
A 1 69  ARG 69  64  64  ARG ARG A . n 
A 1 70  ILE 70  65  65  ILE ILE A . n 
A 1 71  THR 71  66  66  THR THR A . n 
A 1 72  PRO 72  67  67  PRO PRO A . n 
A 1 73  ARG 73  68  68  ARG ARG A . n 
A 1 74  PRO 74  69  69  PRO PRO A . n 
A 1 75  GLU 75  70  70  GLU GLU A . n 
A 1 76  GLU 76  71  71  GLU GLU A . n 
A 1 77  LYS 77  72  72  LYS LYS A . n 
A 1 78  VAL 78  73  73  VAL VAL A . n 
A 1 79  LEU 79  74  74  LEU LEU A . n 
A 1 80  GLU 80  75  75  GLU GLU A . n 
A 1 81  ILE 81  76  76  ILE ILE A . n 
A 1 82  ARG 82  77  77  ARG ARG A . n 
A 1 83  ASP 83  78  78  ASP ASP A . n 
A 1 84  SER 84  79  79  SER SER A . n 
A 1 85  GLY 85  80  80  GLY GLY A . n 
A 1 86  ILE 86  81  81  ILE ILE A . n 
A 1 87  GLY 87  82  82  GLY GLY A . n 
A 1 88  MET 88  83  83  MET MET A . n 
A 1 89  THR 89  84  84  THR THR A . n 
A 1 90  LYS 90  85  85  LYS LYS A . n 
A 1 91  ALA 91  86  86  ALA ALA A . n 
A 1 92  GLU 92  87  87  GLU GLU A . n 
A 1 93  LEU 93  88  88  LEU LEU A . n 
A 1 94  ILE 94  89  89  ILE ILE A . n 
A 1 95  ASN 95  90  90  ASN ASN A . n 
A 1 96  ASN 96  91  91  ASN ASN A . n 
A 1 97  LEU 97  92  92  LEU LEU A . n 
A 1 98  GLY 98  93  93  GLY GLY A . n 
A 1 99  THR 99  94  94  THR THR A . n 
A 1 100 ILE 100 95  95  ILE ILE A . n 
A 1 101 ALA 101 96  96  ALA ALA A . n 
A 1 102 LYS 102 97  97  LYS LYS A . n 
A 1 103 SER 103 98  98  SER SER A . n 
A 1 104 GLY 104 99  99  GLY GLY A . n 
A 1 105 THR 105 100 100 THR THR A . n 
A 1 106 LYS 106 101 101 LYS LYS A . n 
A 1 107 ALA 107 102 102 ALA ALA A . n 
A 1 108 PHE 108 103 103 PHE PHE A . n 
A 1 109 MET 109 104 104 MET MET A . n 
A 1 110 GLU 110 105 105 GLU GLU A . n 
A 1 111 ALA 111 106 106 ALA ALA A . n 
A 1 112 LEU 112 107 107 LEU LEU A . n 
A 1 113 SER 113 108 108 SER SER A . n 
A 1 114 ALA 114 109 109 ALA ALA A . n 
A 1 115 GLY 115 110 110 GLY GLY A . n 
A 1 116 ALA 116 111 111 ALA ALA A . n 
A 1 117 ASP 117 112 112 ASP ASP A . n 
A 1 118 VAL 118 113 113 VAL VAL A . n 
A 1 119 SER 119 114 114 SER SER A . n 
A 1 120 MET 120 115 115 MET MET A . n 
A 1 121 ILE 121 116 116 ILE ILE A . n 
A 1 122 GLY 122 117 117 GLY GLY A . n 
A 1 123 GLN 123 118 118 GLN GLN A . n 
A 1 124 PHE 124 119 119 PHE PHE A . n 
A 1 125 GLY 125 120 120 GLY GLY A . n 
A 1 126 VAL 126 121 121 VAL VAL A . n 
A 1 127 GLY 127 122 122 GLY GLY A . n 
A 1 128 PHE 128 123 123 PHE PHE A . n 
A 1 129 TYR 129 124 124 TYR TYR A . n 
A 1 130 SER 130 125 125 SER SER A . n 
A 1 131 LEU 131 126 126 LEU LEU A . n 
A 1 132 PHE 132 127 127 PHE PHE A . n 
A 1 133 LEU 133 128 128 LEU LEU A . n 
A 1 134 VAL 134 129 129 VAL VAL A . n 
A 1 135 ALA 135 130 130 ALA ALA A . n 
A 1 136 ASP 136 131 131 ASP ASP A . n 
A 1 137 ARG 137 132 132 ARG ARG A . n 
A 1 138 VAL 138 133 133 VAL VAL A . n 
A 1 139 GLN 139 134 134 GLN GLN A . n 
A 1 140 VAL 140 135 135 VAL VAL A . n 
A 1 141 ILE 141 136 136 ILE ILE A . n 
A 1 142 SER 142 137 137 SER SER A . n 
A 1 143 LYS 143 138 138 LYS LYS A . n 
A 1 144 ASN 144 139 139 ASN ASN A . n 
A 1 145 ASN 145 140 140 ASN ASN A . n 
A 1 146 ASP 146 141 141 ASP ASP A . n 
A 1 147 ASP 147 142 142 ASP ASP A . n 
A 1 148 GLU 148 143 143 GLU GLU A . n 
A 1 149 GLN 149 144 144 GLN GLN A . n 
A 1 150 TYR 150 145 145 TYR TYR A . n 
A 1 151 ILE 151 146 146 ILE ILE A . n 
A 1 152 TRP 152 147 147 TRP TRP A . n 
A 1 153 GLU 153 148 148 GLU GLU A . n 
A 1 154 SER 154 149 149 SER SER A . n 
A 1 155 ASN 155 150 150 ASN ASN A . n 
A 1 156 ALA 156 151 151 ALA ALA A . n 
A 1 157 GLY 157 152 152 GLY GLY A . n 
A 1 158 GLY 158 153 153 GLY GLY A . n 
A 1 159 SER 159 154 154 SER SER A . n 
A 1 160 PHE 160 155 155 PHE PHE A . n 
A 1 161 THR 161 156 156 THR THR A . n 
A 1 162 VAL 162 157 157 VAL VAL A . n 
A 1 163 THR 163 158 158 THR THR A . n 
A 1 164 LEU 164 159 159 LEU LEU A . n 
A 1 165 ASP 165 160 160 ASP ASP A . n 
A 1 166 THR 166 161 161 THR THR A . n 
A 1 167 VAL 167 162 162 VAL VAL A . n 
A 1 168 ASN 168 163 163 ASN ASN A . n 
A 1 169 GLU 169 164 164 GLU GLU A . n 
A 1 170 LYS 170 165 165 LYS LYS A . n 
A 1 171 ILE 171 166 166 ILE ILE A . n 
A 1 172 GLY 172 167 167 GLY GLY A . n 
A 1 173 ARG 173 168 168 ARG ARG A . n 
A 1 174 GLY 174 169 169 GLY GLY A . n 
A 1 175 THR 175 170 170 THR THR A . n 
A 1 176 ILE 176 171 171 ILE ILE A . n 
A 1 177 LEU 177 172 172 LEU LEU A . n 
A 1 178 ARG 178 173 173 ARG ARG A . n 
A 1 179 LEU 179 174 174 LEU LEU A . n 
A 1 180 PHE 180 175 175 PHE PHE A . n 
A 1 181 MET 181 176 176 MET MET A . n 
A 1 182 LYS 182 177 177 LYS LYS A . n 
A 1 183 GLU 183 178 178 GLU GLU A . n 
A 1 184 ASP 184 179 179 ASP ASP A . n 
A 1 185 GLN 185 180 180 GLN GLN A . n 
A 1 186 LEU 186 181 181 LEU LEU A . n 
A 1 187 GLU 187 182 182 GLU GLU A . n 
A 1 188 TYR 188 183 183 TYR TYR A . n 
A 1 189 LEU 189 184 184 LEU LEU A . n 
A 1 190 GLU 190 185 185 GLU GLU A . n 
A 1 191 GLU 191 186 186 GLU GLU A . n 
A 1 192 LYS 192 187 187 LYS LYS A . n 
A 1 193 ARG 193 188 188 ARG ARG A . n 
A 1 194 ILE 194 189 189 ILE ILE A . n 
A 1 195 LYS 195 190 190 LYS LYS A . n 
A 1 196 GLU 196 191 191 GLU GLU A . n 
A 1 197 VAL 197 192 192 VAL VAL A . n 
A 1 198 VAL 198 193 193 VAL VAL A . n 
A 1 199 LYS 199 194 194 LYS LYS A . n 
A 1 200 LYS 200 195 195 LYS LYS A . n 
A 1 201 HIS 201 196 196 HIS HIS A . n 
A 1 202 SER 202 197 197 SER SER A . n 
A 1 203 GLU 203 198 198 GLU GLU A . n 
A 1 204 PHE 204 199 199 PHE PHE A . n 
A 1 205 VAL 205 200 200 VAL VAL A . n 
A 1 206 ALA 206 201 201 ALA ALA A . n 
A 1 207 TYR 207 202 202 TYR TYR A . n 
A 1 208 PRO 208 203 203 PRO PRO A . n 
A 1 209 ILE 209 204 204 ILE ILE A . n 
A 1 210 GLN 210 205 205 GLN GLN A . n 
A 1 211 LEU 211 206 206 LEU LEU A . n 
A 1 212 MET 212 207 207 MET MET A . n 
A 1 213 VAL 213 208 208 VAL VAL A . n 
A 1 214 THR 214 209 209 THR THR A . n 
A 1 215 LYS 215 210 210 LYS LYS A . n 
A 1 216 GLU 216 211 211 GLU GLU A . n 
A 1 217 VAL 217 212 212 VAL VAL A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   301 38  HOH HOH A . 
B 2 HOH 2   302 31  HOH HOH A . 
B 2 HOH 3   303 108 HOH HOH A . 
B 2 HOH 4   304 60  HOH HOH A . 
B 2 HOH 5   305 22  HOH HOH A . 
B 2 HOH 6   306 24  HOH HOH A . 
B 2 HOH 7   307 82  HOH HOH A . 
B 2 HOH 8   308 62  HOH HOH A . 
B 2 HOH 9   309 19  HOH HOH A . 
B 2 HOH 10  310 42  HOH HOH A . 
B 2 HOH 11  311 133 HOH HOH A . 
B 2 HOH 12  312 9   HOH HOH A . 
B 2 HOH 13  313 84  HOH HOH A . 
B 2 HOH 14  314 79  HOH HOH A . 
B 2 HOH 15  315 100 HOH HOH A . 
B 2 HOH 16  316 135 HOH HOH A . 
B 2 HOH 17  317 7   HOH HOH A . 
B 2 HOH 18  318 160 HOH HOH A . 
B 2 HOH 19  319 4   HOH HOH A . 
B 2 HOH 20  320 98  HOH HOH A . 
B 2 HOH 21  321 132 HOH HOH A . 
B 2 HOH 22  322 6   HOH HOH A . 
B 2 HOH 23  323 97  HOH HOH A . 
B 2 HOH 24  324 5   HOH HOH A . 
B 2 HOH 25  325 151 HOH HOH A . 
B 2 HOH 26  326 173 HOH HOH A . 
B 2 HOH 27  327 10  HOH HOH A . 
B 2 HOH 28  328 174 HOH HOH A . 
B 2 HOH 29  329 46  HOH HOH A . 
B 2 HOH 30  330 71  HOH HOH A . 
B 2 HOH 31  331 158 HOH HOH A . 
B 2 HOH 32  332 67  HOH HOH A . 
B 2 HOH 33  333 39  HOH HOH A . 
B 2 HOH 34  334 111 HOH HOH A . 
B 2 HOH 35  335 88  HOH HOH A . 
B 2 HOH 36  336 23  HOH HOH A . 
B 2 HOH 37  337 91  HOH HOH A . 
B 2 HOH 38  338 12  HOH HOH A . 
B 2 HOH 39  339 57  HOH HOH A . 
B 2 HOH 40  340 53  HOH HOH A . 
B 2 HOH 41  341 115 HOH HOH A . 
B 2 HOH 42  342 48  HOH HOH A . 
B 2 HOH 43  343 36  HOH HOH A . 
B 2 HOH 44  344 93  HOH HOH A . 
B 2 HOH 45  345 103 HOH HOH A . 
B 2 HOH 46  346 18  HOH HOH A . 
B 2 HOH 47  347 96  HOH HOH A . 
B 2 HOH 48  348 43  HOH HOH A . 
B 2 HOH 49  349 3   HOH HOH A . 
B 2 HOH 50  350 21  HOH HOH A . 
B 2 HOH 51  351 37  HOH HOH A . 
B 2 HOH 52  352 2   HOH HOH A . 
B 2 HOH 53  353 8   HOH HOH A . 
B 2 HOH 54  354 47  HOH HOH A . 
B 2 HOH 55  355 169 HOH HOH A . 
B 2 HOH 56  356 74  HOH HOH A . 
B 2 HOH 57  357 33  HOH HOH A . 
B 2 HOH 58  358 54  HOH HOH A . 
B 2 HOH 59  359 139 HOH HOH A . 
B 2 HOH 60  360 26  HOH HOH A . 
B 2 HOH 61  361 129 HOH HOH A . 
B 2 HOH 62  362 66  HOH HOH A . 
B 2 HOH 63  363 61  HOH HOH A . 
B 2 HOH 64  364 49  HOH HOH A . 
B 2 HOH 65  365 41  HOH HOH A . 
B 2 HOH 66  366 17  HOH HOH A . 
B 2 HOH 67  367 164 HOH HOH A . 
B 2 HOH 68  368 14  HOH HOH A . 
B 2 HOH 69  369 45  HOH HOH A . 
B 2 HOH 70  370 113 HOH HOH A . 
B 2 HOH 71  371 167 HOH HOH A . 
B 2 HOH 72  372 25  HOH HOH A . 
B 2 HOH 73  373 80  HOH HOH A . 
B 2 HOH 74  374 177 HOH HOH A . 
B 2 HOH 75  375 99  HOH HOH A . 
B 2 HOH 76  376 15  HOH HOH A . 
B 2 HOH 77  377 50  HOH HOH A . 
B 2 HOH 78  378 29  HOH HOH A . 
B 2 HOH 79  379 63  HOH HOH A . 
B 2 HOH 80  380 159 HOH HOH A . 
B 2 HOH 81  381 110 HOH HOH A . 
B 2 HOH 82  382 64  HOH HOH A . 
B 2 HOH 83  383 27  HOH HOH A . 
B 2 HOH 84  384 13  HOH HOH A . 
B 2 HOH 85  385 140 HOH HOH A . 
B 2 HOH 86  386 55  HOH HOH A . 
B 2 HOH 87  387 77  HOH HOH A . 
B 2 HOH 88  388 28  HOH HOH A . 
B 2 HOH 89  389 72  HOH HOH A . 
B 2 HOH 90  390 112 HOH HOH A . 
B 2 HOH 91  391 32  HOH HOH A . 
B 2 HOH 92  392 1   HOH HOH A . 
B 2 HOH 93  393 142 HOH HOH A . 
B 2 HOH 94  394 78  HOH HOH A . 
B 2 HOH 95  395 81  HOH HOH A . 
B 2 HOH 96  396 11  HOH HOH A . 
B 2 HOH 97  397 59  HOH HOH A . 
B 2 HOH 98  398 52  HOH HOH A . 
B 2 HOH 99  399 104 HOH HOH A . 
B 2 HOH 100 400 175 HOH HOH A . 
B 2 HOH 101 401 20  HOH HOH A . 
B 2 HOH 102 402 34  HOH HOH A . 
B 2 HOH 103 403 156 HOH HOH A . 
B 2 HOH 104 404 16  HOH HOH A . 
B 2 HOH 105 405 75  HOH HOH A . 
B 2 HOH 106 406 148 HOH HOH A . 
B 2 HOH 107 407 106 HOH HOH A . 
B 2 HOH 108 408 141 HOH HOH A . 
B 2 HOH 109 409 83  HOH HOH A . 
B 2 HOH 110 410 179 HOH HOH A . 
B 2 HOH 111 411 127 HOH HOH A . 
B 2 HOH 112 412 125 HOH HOH A . 
B 2 HOH 113 413 162 HOH HOH A . 
B 2 HOH 114 414 85  HOH HOH A . 
B 2 HOH 115 415 170 HOH HOH A . 
B 2 HOH 116 416 134 HOH HOH A . 
B 2 HOH 117 417 150 HOH HOH A . 
B 2 HOH 118 418 178 HOH HOH A . 
B 2 HOH 119 419 86  HOH HOH A . 
B 2 HOH 120 420 58  HOH HOH A . 
B 2 HOH 121 421 105 HOH HOH A . 
B 2 HOH 122 422 109 HOH HOH A . 
B 2 HOH 123 423 131 HOH HOH A . 
B 2 HOH 124 424 153 HOH HOH A . 
B 2 HOH 125 425 70  HOH HOH A . 
B 2 HOH 126 426 163 HOH HOH A . 
B 2 HOH 127 427 30  HOH HOH A . 
B 2 HOH 128 428 117 HOH HOH A . 
B 2 HOH 129 429 126 HOH HOH A . 
B 2 HOH 130 430 92  HOH HOH A . 
B 2 HOH 131 431 171 HOH HOH A . 
B 2 HOH 132 432 121 HOH HOH A . 
B 2 HOH 133 433 124 HOH HOH A . 
B 2 HOH 134 434 146 HOH HOH A . 
B 2 HOH 135 435 76  HOH HOH A . 
B 2 HOH 136 436 165 HOH HOH A . 
B 2 HOH 137 437 119 HOH HOH A . 
B 2 HOH 138 438 89  HOH HOH A . 
B 2 HOH 139 439 40  HOH HOH A . 
B 2 HOH 140 440 101 HOH HOH A . 
B 2 HOH 141 441 107 HOH HOH A . 
B 2 HOH 142 442 138 HOH HOH A . 
B 2 HOH 143 443 152 HOH HOH A . 
B 2 HOH 144 444 120 HOH HOH A . 
B 2 HOH 145 445 73  HOH HOH A . 
B 2 HOH 146 446 168 HOH HOH A . 
B 2 HOH 147 447 51  HOH HOH A . 
B 2 HOH 148 448 130 HOH HOH A . 
B 2 HOH 149 449 155 HOH HOH A . 
B 2 HOH 150 450 180 HOH HOH A . 
B 2 HOH 151 451 87  HOH HOH A . 
B 2 HOH 152 452 94  HOH HOH A . 
B 2 HOH 153 453 147 HOH HOH A . 
B 2 HOH 154 454 145 HOH HOH A . 
B 2 HOH 155 455 128 HOH HOH A . 
B 2 HOH 156 456 90  HOH HOH A . 
B 2 HOH 157 457 154 HOH HOH A . 
B 2 HOH 158 458 95  HOH HOH A . 
B 2 HOH 159 459 166 HOH HOH A . 
B 2 HOH 160 460 123 HOH HOH A . 
B 2 HOH 161 461 114 HOH HOH A . 
B 2 HOH 162 462 56  HOH HOH A . 
B 2 HOH 163 463 149 HOH HOH A . 
B 2 HOH 164 464 137 HOH HOH A . 
B 2 HOH 165 465 116 HOH HOH A . 
B 2 HOH 166 466 102 HOH HOH A . 
B 2 HOH 167 467 122 HOH HOH A . 
B 2 HOH 168 468 176 HOH HOH A . 
B 2 HOH 169 469 172 HOH HOH A . 
B 2 HOH 170 470 157 HOH HOH A . 
B 2 HOH 171 471 44  HOH HOH A . 
B 2 HOH 172 472 69  HOH HOH A . 
B 2 HOH 173 473 118 HOH HOH A . 
B 2 HOH 174 474 65  HOH HOH A . 
B 2 HOH 175 475 68  HOH HOH A . 
B 2 HOH 176 476 136 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YJG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     73.942 
_cell.length_a_esd                 ? 
_cell.length_b                     73.942 
_cell.length_b_esd                 ? 
_cell.length_c                     108.657 
_cell.length_c_esd                 ? 
_cell.volume                       594073.386 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YJG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                95 
_symmetry.space_group_name_Hall            'P 4cw 2c' 
_symmetry.space_group_name_H-M             'P 43 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YJG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.10 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          60.27 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M HEPES pH7.5, 70% (v/v) 2-methyl-2,4-pentanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 270' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9795 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 7A (6B, 6C1)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9795 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '7A (6B, 6C1)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          29.36 
_reflns.entry_id                                       8YJG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24325 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          48.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.075 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.93 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           7.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1193 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               7.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.444 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.32 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YJG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             30.57 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24255 
_refine.ls_number_reflns_R_free                  1997 
_refine.ls_number_reflns_R_work                  22258 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.24 
_refine.ls_percent_reflns_R_free                 8.23 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2046 
_refine.ls_R_factor_R_free                       0.2251 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2027 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.6914 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1951 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        30.57 
_refine_hist.number_atoms_solvent             176 
_refine_hist.number_atoms_total               1860 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1684 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0067  ? 1708 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8825  ? 2301 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0542  ? 266  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0062  ? 295  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.3388 ? 648  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.95  . . 140 1557 99.41  . . . . 0.2299 . . . . . . . . . . . 0.2719 
'X-RAY DIFFRACTION' 1.95 2.00  . . 141 1562 100.00 . . . . 0.2221 . . . . . . . . . . . 0.2851 
'X-RAY DIFFRACTION' 2.00 2.06  . . 140 1568 99.88  . . . . 0.2006 . . . . . . . . . . . 0.2735 
'X-RAY DIFFRACTION' 2.06 2.13  . . 141 1561 99.82  . . . . 0.1976 . . . . . . . . . . . 0.2609 
'X-RAY DIFFRACTION' 2.13 2.20  . . 142 1577 99.88  . . . . 0.2072 . . . . . . . . . . . 0.2362 
'X-RAY DIFFRACTION' 2.20 2.29  . . 139 1564 99.77  . . . . 0.2079 . . . . . . . . . . . 0.2520 
'X-RAY DIFFRACTION' 2.29 2.39  . . 142 1594 99.77  . . . . 0.2069 . . . . . . . . . . . 0.2481 
'X-RAY DIFFRACTION' 2.39 2.52  . . 142 1580 99.94  . . . . 0.2078 . . . . . . . . . . . 0.2581 
'X-RAY DIFFRACTION' 2.52 2.68  . . 143 1593 100.00 . . . . 0.2112 . . . . . . . . . . . 0.2244 
'X-RAY DIFFRACTION' 2.68 2.88  . . 142 1587 99.71  . . . . 0.2145 . . . . . . . . . . . 0.2249 
'X-RAY DIFFRACTION' 2.88 3.17  . . 145 1616 99.94  . . . . 0.2054 . . . . . . . . . . . 0.2317 
'X-RAY DIFFRACTION' 3.17 3.63  . . 146 1625 99.89  . . . . 0.1920 . . . . . . . . . . . 0.2197 
'X-RAY DIFFRACTION' 3.63 4.57  . . 148 1636 99.11  . . . . 0.1741 . . . . . . . . . . . 0.1865 
'X-RAY DIFFRACTION' 4.58 30.57 . . 146 1638 93.01  . . . . 0.2252 . . . . . . . . . . . 0.2186 
# 
_struct.entry_id                     8YJG 
_struct.title                        'Crystal structure of the nucleotide-binding domain of Candida glabrata Hsp90' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YJG 
_struct_keywords.text            'Hsp90, ATPase, CHAPERONE' 
_struct_keywords.pdbx_keywords   CHAPERONE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0W0DX49_CANGB 
_struct_ref.pdbx_db_accession          A0A0W0DX49 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDAIDKIRYQALSDPKQLETEPELFIRITPRPEEKVLEIRDSGI
GMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNDDEQYIWESNAGGSFTVTLDT
VNEKIGRGTILRLFMKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLMVTKEV
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YJG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 7 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 217 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A0W0DX49 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  212 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       212 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YJG GLY A 1 ? UNP A0A0W0DX49 ? ? 'expression tag' -4 1 
1 8YJG SER A 2 ? UNP A0A0W0DX49 ? ? 'expression tag' -3 2 
1 8YJG ALA A 3 ? UNP A0A0W0DX49 ? ? 'expression tag' -2 3 
1 8YJG MET A 4 ? UNP A0A0W0DX49 ? ? 'expression tag' -1 4 
1 8YJG GLY A 5 ? UNP A0A0W0DX49 ? ? 'expression tag' 0  5 
1 8YJG SER A 6 ? UNP A0A0W0DX49 ? ? 'expression tag' 1  6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLN A 13  ? THR A 26  ? GLN A 8   THR A 21  1 ? 14 
HELX_P HELX_P2  AA2 GLU A 32  ? SER A 55  ? GLU A 27  SER A 50  1 ? 24 
HELX_P HELX_P3  AA3 ASP A 56  ? GLU A 63  ? ASP A 51  GLU A 58  5 ? 8  
HELX_P HELX_P4  AA4 PRO A 74  ? GLU A 76  ? PRO A 69  GLU A 71  5 ? 3  
HELX_P HELX_P5  AA5 THR A 89  ? GLY A 98  ? THR A 84  GLY A 93  1 ? 10 
HELX_P HELX_P6  AA6 LYS A 102 ? GLY A 115 ? LYS A 97  GLY A 110 1 ? 14 
HELX_P HELX_P7  AA7 ASP A 117 ? GLY A 125 ? ASP A 112 GLY A 120 5 ? 9  
HELX_P HELX_P8  AA8 VAL A 126 ? LEU A 133 ? VAL A 121 LEU A 128 5 ? 8  
HELX_P HELX_P9  AA9 GLU A 183 ? LEU A 189 ? GLU A 178 LEU A 184 5 ? 7  
HELX_P HELX_P10 AB1 GLU A 190 ? LYS A 200 ? GLU A 185 LYS A 195 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   8 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 8   ? GLU A 11  ? GLU A 3   GLU A 6   
AA1 2 SER A 159 ? LEU A 164 ? SER A 154 LEU A 159 
AA1 3 TYR A 150 ? SER A 154 ? TYR A 145 SER A 149 
AA1 4 ALA A 135 ? LYS A 143 ? ALA A 130 LYS A 138 
AA1 5 GLY A 174 ? MET A 181 ? GLY A 169 MET A 176 
AA1 6 VAL A 78  ? ASP A 83  ? VAL A 73  ASP A 78  
AA1 7 ILE A 68  ? ARG A 73  ? ILE A 63  ARG A 68  
AA1 8 ILE A 209 ? LEU A 211 ? ILE A 204 LEU A 206 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 10  ? N PHE A 5   O PHE A 160 ? O PHE A 155 
AA1 2 3 O THR A 163 ? O THR A 158 N ILE A 151 ? N ILE A 146 
AA1 3 4 O TRP A 152 ? O TRP A 147 N VAL A 140 ? N VAL A 135 
AA1 4 5 N GLN A 139 ? N GLN A 134 O ARG A 178 ? O ARG A 173 
AA1 5 6 O LEU A 179 ? O LEU A 174 N LEU A 79  ? N LEU A 74  
AA1 6 7 O ARG A 82  ? O ARG A 77  N ARG A 69  ? N ARG A 64  
AA1 7 8 N ILE A 68  ? N ILE A 63  O GLN A 210 ? O GLN A 205 
# 
_pdbx_entry_details.entry_id                   8YJG 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 51  ? ? -160.47 70.00  
2 1 GLU A 58  ? ? -163.22 89.90  
3 1 SER A 79  ? ? -98.17  40.50  
4 1 ILE A 95  ? ? -127.84 -80.97 
5 1 ALA A 96  ? ? 30.01   35.06  
6 1 HIS A 196 ? ? -140.53 23.80  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 433 ? B HOH . 
2 1 A HOH 446 ? B HOH . 
3 1 A HOH 469 ? B HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z        
2 -y,x,z+3/4   
3 y,-x,z+1/4   
4 x,-y,-z+1/2  
5 -x,y,-z      
6 -x,-y,z+1/2  
7 y,x,-z+1/4   
8 -y,-x,-z+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -4 ? A GLY 1 
2 1 Y 1 A SER -3 ? A SER 2 
3 1 Y 1 A ALA -2 ? A ALA 3 
4 1 Y 1 A MET -1 ? A MET 4 
5 1 Y 1 A GLY 0  ? A GLY 5 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
LEU N    N N N 169 
LEU CA   C N S 170 
LEU C    C N N 171 
LEU O    O N N 172 
LEU CB   C N N 173 
LEU CG   C N N 174 
LEU CD1  C N N 175 
LEU CD2  C N N 176 
LEU OXT  O N N 177 
LEU H    H N N 178 
LEU H2   H N N 179 
LEU HA   H N N 180 
LEU HB2  H N N 181 
LEU HB3  H N N 182 
LEU HG   H N N 183 
LEU HD11 H N N 184 
LEU HD12 H N N 185 
LEU HD13 H N N 186 
LEU HD21 H N N 187 
LEU HD22 H N N 188 
LEU HD23 H N N 189 
LEU HXT  H N N 190 
LYS N    N N N 191 
LYS CA   C N S 192 
LYS C    C N N 193 
LYS O    O N N 194 
LYS CB   C N N 195 
LYS CG   C N N 196 
LYS CD   C N N 197 
LYS CE   C N N 198 
LYS NZ   N N N 199 
LYS OXT  O N N 200 
LYS H    H N N 201 
LYS H2   H N N 202 
LYS HA   H N N 203 
LYS HB2  H N N 204 
LYS HB3  H N N 205 
LYS HG2  H N N 206 
LYS HG3  H N N 207 
LYS HD2  H N N 208 
LYS HD3  H N N 209 
LYS HE2  H N N 210 
LYS HE3  H N N 211 
LYS HZ1  H N N 212 
LYS HZ2  H N N 213 
LYS HZ3  H N N 214 
LYS HXT  H N N 215 
MET N    N N N 216 
MET CA   C N S 217 
MET C    C N N 218 
MET O    O N N 219 
MET CB   C N N 220 
MET CG   C N N 221 
MET SD   S N N 222 
MET CE   C N N 223 
MET OXT  O N N 224 
MET H    H N N 225 
MET H2   H N N 226 
MET HA   H N N 227 
MET HB2  H N N 228 
MET HB3  H N N 229 
MET HG2  H N N 230 
MET HG3  H N N 231 
MET HE1  H N N 232 
MET HE2  H N N 233 
MET HE3  H N N 234 
MET HXT  H N N 235 
PHE N    N N N 236 
PHE CA   C N S 237 
PHE C    C N N 238 
PHE O    O N N 239 
PHE CB   C N N 240 
PHE CG   C Y N 241 
PHE CD1  C Y N 242 
PHE CD2  C Y N 243 
PHE CE1  C Y N 244 
PHE CE2  C Y N 245 
PHE CZ   C Y N 246 
PHE OXT  O N N 247 
PHE H    H N N 248 
PHE H2   H N N 249 
PHE HA   H N N 250 
PHE HB2  H N N 251 
PHE HB3  H N N 252 
PHE HD1  H N N 253 
PHE HD2  H N N 254 
PHE HE1  H N N 255 
PHE HE2  H N N 256 
PHE HZ   H N N 257 
PHE HXT  H N N 258 
PRO N    N N N 259 
PRO CA   C N S 260 
PRO C    C N N 261 
PRO O    O N N 262 
PRO CB   C N N 263 
PRO CG   C N N 264 
PRO CD   C N N 265 
PRO OXT  O N N 266 
PRO H    H N N 267 
PRO HA   H N N 268 
PRO HB2  H N N 269 
PRO HB3  H N N 270 
PRO HG2  H N N 271 
PRO HG3  H N N 272 
PRO HD2  H N N 273 
PRO HD3  H N N 274 
PRO HXT  H N N 275 
SER N    N N N 276 
SER CA   C N S 277 
SER C    C N N 278 
SER O    O N N 279 
SER CB   C N N 280 
SER OG   O N N 281 
SER OXT  O N N 282 
SER H    H N N 283 
SER H2   H N N 284 
SER HA   H N N 285 
SER HB2  H N N 286 
SER HB3  H N N 287 
SER HG   H N N 288 
SER HXT  H N N 289 
THR N    N N N 290 
THR CA   C N S 291 
THR C    C N N 292 
THR O    O N N 293 
THR CB   C N R 294 
THR OG1  O N N 295 
THR CG2  C N N 296 
THR OXT  O N N 297 
THR H    H N N 298 
THR H2   H N N 299 
THR HA   H N N 300 
THR HB   H N N 301 
THR HG1  H N N 302 
THR HG21 H N N 303 
THR HG22 H N N 304 
THR HG23 H N N 305 
THR HXT  H N N 306 
TRP N    N N N 307 
TRP CA   C N S 308 
TRP C    C N N 309 
TRP O    O N N 310 
TRP CB   C N N 311 
TRP CG   C Y N 312 
TRP CD1  C Y N 313 
TRP CD2  C Y N 314 
TRP NE1  N Y N 315 
TRP CE2  C Y N 316 
TRP CE3  C Y N 317 
TRP CZ2  C Y N 318 
TRP CZ3  C Y N 319 
TRP CH2  C Y N 320 
TRP OXT  O N N 321 
TRP H    H N N 322 
TRP H2   H N N 323 
TRP HA   H N N 324 
TRP HB2  H N N 325 
TRP HB3  H N N 326 
TRP HD1  H N N 327 
TRP HE1  H N N 328 
TRP HE3  H N N 329 
TRP HZ2  H N N 330 
TRP HZ3  H N N 331 
TRP HH2  H N N 332 
TRP HXT  H N N 333 
TYR N    N N N 334 
TYR CA   C N S 335 
TYR C    C N N 336 
TYR O    O N N 337 
TYR CB   C N N 338 
TYR CG   C Y N 339 
TYR CD1  C Y N 340 
TYR CD2  C Y N 341 
TYR CE1  C Y N 342 
TYR CE2  C Y N 343 
TYR CZ   C Y N 344 
TYR OH   O N N 345 
TYR OXT  O N N 346 
TYR H    H N N 347 
TYR H2   H N N 348 
TYR HA   H N N 349 
TYR HB2  H N N 350 
TYR HB3  H N N 351 
TYR HD1  H N N 352 
TYR HD2  H N N 353 
TYR HE1  H N N 354 
TYR HE2  H N N 355 
TYR HH   H N N 356 
TYR HXT  H N N 357 
VAL N    N N N 358 
VAL CA   C N S 359 
VAL C    C N N 360 
VAL O    O N N 361 
VAL CB   C N N 362 
VAL CG1  C N N 363 
VAL CG2  C N N 364 
VAL OXT  O N N 365 
VAL H    H N N 366 
VAL H2   H N N 367 
VAL HA   H N N 368 
VAL HB   H N N 369 
VAL HG11 H N N 370 
VAL HG12 H N N 371 
VAL HG13 H N N 372 
VAL HG21 H N N 373 
VAL HG22 H N N 374 
VAL HG23 H N N 375 
VAL HXT  H N N 376 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           RS-2023-00241410 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2CG9 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 2 2' 
_space_group.name_Hall        'P 4cw 2c' 
_space_group.IT_number        95 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YJG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013524 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013524 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009203 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 6   ? -7.25375  50.97469 5.64404   1.000 56.72534 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 6   ? -8.33918  51.95290 5.59642   1.000 53.70985 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 6   ? -9.71425  51.27949 5.57197   1.000 44.09937 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 6   ? -10.46942 51.41229 4.60724   1.000 45.94568 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 6   ? -8.16979  52.85774 4.37511   1.000 52.72236 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 6   ? -7.62729  52.12487 3.28462   1.000 59.19557 ? 1   SER A OG  1 
ATOM   7    N N   . SER A 1 7   ? -10.04116 50.57797 6.65141   1.000 45.56214 ? 2   SER A N   1 
ATOM   8    C CA  . SER A 1 7   ? -11.27641 49.80615 6.69974   1.000 42.16684 ? 2   SER A CA  1 
ATOM   9    C C   . SER A 1 7   ? -12.49970 50.71491 6.74559   1.000 45.19434 ? 2   SER A C   1 
ATOM   10   O O   . SER A 1 7   ? -12.52580 51.70024 7.48597   1.000 45.01237 ? 2   SER A O   1 
ATOM   11   C CB  . SER A 1 7   ? -11.26628 48.89568 7.91872   1.000 41.60088 ? 2   SER A CB  1 
ATOM   12   O OG  . SER A 1 7   ? -10.06292 48.15058 7.96065   1.000 50.14013 ? 2   SER A OG  1 
ATOM   13   N N   . GLU A 1 8   ? -13.51478 50.37682 5.95517   1.000 39.19541 ? 3   GLU A N   1 
ATOM   14   C CA  . GLU A 1 8   ? -14.83099 50.98844 6.05407   1.000 36.82612 ? 3   GLU A CA  1 
ATOM   15   C C   . GLU A 1 8   ? -15.77797 50.00637 6.73111   1.000 37.59849 ? 3   GLU A C   1 
ATOM   16   O O   . GLU A 1 8   ? -15.72690 48.80265 6.46388   1.000 32.99139 ? 3   GLU A O   1 
ATOM   17   C CB  . GLU A 1 8   ? -15.36074 51.37924 4.67495   1.000 40.56676 ? 3   GLU A CB  1 
ATOM   18   C CG  . GLU A 1 8   ? -14.48705 52.40189 3.95153   1.000 45.67924 ? 3   GLU A CG  1 
ATOM   19   C CD  . GLU A 1 8   ? -15.07551 52.84449 2.62473   1.000 50.45241 ? 3   GLU A CD  1 
ATOM   20   O OE1 . GLU A 1 8   ? -15.64702 52.00019 1.90486   1.000 51.87161 ? 3   GLU A OE1 1 
ATOM   21   O OE2 . GLU A 1 8   ? -14.97595 54.04650 2.30079   1.000 58.54052 ? 3   GLU A OE2 1 
ATOM   22   N N   . THR A 1 9   ? -16.61850 50.51497 7.62884   1.000 35.01108 ? 4   THR A N   1 
ATOM   23   C CA  . THR A 1 9   ? -17.57456 49.68939 8.36040   1.000 37.48595 ? 4   THR A CA  1 
ATOM   24   C C   . THR A 1 9   ? -18.97485 49.91421 7.80466   1.000 36.92603 ? 4   THR A C   1 
ATOM   25   O O   . THR A 1 9   ? -19.34262 51.04318 7.46913   1.000 37.39288 ? 4   THR A O   1 
ATOM   26   C CB  . THR A 1 9   ? -17.53905 50.00084 9.85819   1.000 38.25725 ? 4   THR A CB  1 
ATOM   27   O OG1 . THR A 1 9   ? -16.21234 49.79416 10.34216  1.000 42.44485 ? 4   THR A OG1 1 
ATOM   28   C CG2 . THR A 1 9   ? -18.48224 49.08690 10.63641  1.000 35.04726 ? 4   THR A CG2 1 
ATOM   29   N N   . PHE A 1 10  ? -19.73880 48.82431 7.67537   1.000 35.66498 ? 5   PHE A N   1 
ATOM   30   C CA  . PHE A 1 10  ? -21.08497 48.84959 7.11327   1.000 35.76199 ? 5   PHE A CA  1 
ATOM   31   C C   . PHE A 1 10  ? -22.02670 48.05738 8.01057   1.000 35.98322 ? 5   PHE A C   1 
ATOM   32   O O   . PHE A 1 10  ? -21.60605 47.14391 8.72293   1.000 36.21313 ? 5   PHE A O   1 
ATOM   33   C CB  . PHE A 1 10  ? -21.12303 48.26278 5.68080   1.000 35.35192 ? 5   PHE A CB  1 
ATOM   34   C CG  . PHE A 1 10  ? -20.21654 48.97030 4.70094   1.000 33.09140 ? 5   PHE A CG  1 
ATOM   35   C CD1 . PHE A 1 10  ? -18.87960 48.62377 4.59654   1.000 31.23703 ? 5   PHE A CD1 1 
ATOM   36   C CD2 . PHE A 1 10  ? -20.70928 49.97166 3.87810   1.000 34.65849 ? 5   PHE A CD2 1 
ATOM   37   C CE1 . PHE A 1 10  ? -18.05284 49.26629 3.70408   1.000 31.81857 ? 5   PHE A CE1 1 
ATOM   38   C CE2 . PHE A 1 10  ? -19.88605 50.61905 2.97818   1.000 36.50468 ? 5   PHE A CE2 1 
ATOM   39   C CZ  . PHE A 1 10  ? -18.55718 50.27013 2.89283   1.000 36.63714 ? 5   PHE A CZ  1 
ATOM   40   N N   . GLU A 1 11  ? -23.31153 48.40206 7.97235   1.000 36.06525 ? 6   GLU A N   1 
ATOM   41   C CA  . GLU A 1 11  ? -24.29837 47.67819 8.76664   1.000 41.44390 ? 6   GLU A CA  1 
ATOM   42   C C   . GLU A 1 11  ? -24.94098 46.58345 7.92645   1.000 31.75521 ? 6   GLU A C   1 
ATOM   43   O O   . GLU A 1 11  ? -25.23385 46.78738 6.74718   1.000 33.14104 ? 6   GLU A O   1 
ATOM   44   C CB  . GLU A 1 11  ? -25.37103 48.62517 9.30953   1.000 45.84452 ? 6   GLU A CB  1 
ATOM   45   C CG  . GLU A 1 11  ? -25.08508 49.12664 10.72144  1.000 51.37526 ? 6   GLU A CG  1 
ATOM   46   C CD  . GLU A 1 11  ? -25.22174 48.02933 11.77096  1.000 54.55589 ? 6   GLU A CD  1 
ATOM   47   O OE1 . GLU A 1 11  ? -26.15364 47.19225 11.65468  1.000 55.43275 ? 6   GLU A OE1 1 
ATOM   48   O OE2 . GLU A 1 11  ? -24.39262 47.99726 12.71304  1.000 57.49857 ? 6   GLU A OE2 1 
ATOM   49   N N   . PHE A 1 12  ? -25.11297 45.40685 8.52690   1.000 33.90363 ? 7   PHE A N   1 
ATOM   50   C CA  . PHE A 1 12  ? -25.88679 44.35607 7.88176   1.000 35.34612 ? 7   PHE A CA  1 
ATOM   51   C C   . PHE A 1 12  ? -27.36031 44.74650 7.81676   1.000 36.56131 ? 7   PHE A C   1 
ATOM   52   O O   . PHE A 1 12  ? -27.89126 45.39146 8.72622   1.000 34.91488 ? 7   PHE A O   1 
ATOM   53   C CB  . PHE A 1 12  ? -25.77723 43.03350 8.65024   1.000 34.34442 ? 7   PHE A CB  1 
ATOM   54   C CG  . PHE A 1 12  ? -24.51351 42.23854 8.37960   1.000 33.70654 ? 7   PHE A CG  1 
ATOM   55   C CD1 . PHE A 1 12  ? -24.38611 41.48179 7.22449   1.000 31.85165 ? 7   PHE A CD1 1 
ATOM   56   C CD2 . PHE A 1 12  ? -23.48998 42.19768 9.32042   1.000 34.04969 ? 7   PHE A CD2 1 
ATOM   57   C CE1 . PHE A 1 12  ? -23.24506 40.72865 6.98557   1.000 30.34642 ? 7   PHE A CE1 1 
ATOM   58   C CE2 . PHE A 1 12  ? -22.34140 41.44596 9.09515   1.000 32.47500 ? 7   PHE A CE2 1 
ATOM   59   C CZ  . PHE A 1 12  ? -22.21884 40.70969 7.92436   1.000 33.62307 ? 7   PHE A CZ  1 
ATOM   60   N N   . GLN A 1 13  ? -28.02872 44.32447 6.73911   1.000 36.59555 ? 8   GLN A N   1 
ATOM   61   C CA  . GLN A 1 13  ? -29.48231 44.22333 6.78136   1.000 35.50463 ? 8   GLN A CA  1 
ATOM   62   C C   . GLN A 1 13  ? -29.89386 43.39265 7.98633   1.000 35.93087 ? 8   GLN A C   1 
ATOM   63   O O   . GLN A 1 13  ? -29.27593 42.36734 8.28871   1.000 32.30054 ? 8   GLN A O   1 
ATOM   64   C CB  . GLN A 1 13  ? -30.03230 43.57136 5.51389   1.000 40.33998 ? 8   GLN A CB  1 
ATOM   65   C CG  . GLN A 1 13  ? -30.19296 44.47718 4.33447   1.000 49.21214 ? 8   GLN A CG  1 
ATOM   66   C CD  . GLN A 1 13  ? -30.92285 45.76900 4.65824   1.000 54.77715 ? 8   GLN A CD  1 
ATOM   67   O OE1 . GLN A 1 13  ? -32.15288 45.80560 4.70087   1.000 59.27969 ? 8   GLN A OE1 1 
ATOM   68   N NE2 . GLN A 1 13  ? -30.16346 46.84283 4.87326   1.000 52.81380 ? 8   GLN A NE2 1 
ATOM   69   N N   . ALA A 1 14  ? -30.95622 43.83809 8.66818   1.000 34.05590 ? 9   ALA A N   1 
ATOM   70   C CA  . ALA A 1 14  ? -31.36237 43.21381 9.92324   1.000 34.66383 ? 9   ALA A CA  1 
ATOM   71   C C   . ALA A 1 14  ? -31.59402 41.71352 9.76775   1.000 30.41303 ? 9   ALA A C   1 
ATOM   72   O O   . ALA A 1 14  ? -31.20736 40.92680 10.63701  1.000 29.62235 ? 9   ALA A O   1 
ATOM   73   C CB  . ALA A 1 14  ? -32.62968 43.89102 10.45738  1.000 37.47271 ? 9   ALA A CB  1 
ATOM   74   N N   . GLU A 1 15  ? -32.21869 41.30069 8.66473   1.000 28.42680 ? 10  GLU A N   1 
ATOM   75   C CA  . GLU A 1 15  ? -32.53134 39.88555 8.47755   1.000 28.86588 ? 10  GLU A CA  1 
ATOM   76   C C   . GLU A 1 15  ? -31.26217 39.04198 8.35500   1.000 28.35167 ? 10  GLU A C   1 
ATOM   77   O O   . GLU A 1 15  ? -31.23243 37.88597 8.79846   1.000 26.72693 ? 10  GLU A O   1 
ATOM   78   C CB  . GLU A 1 15  ? -33.42775 39.70814 7.25022   1.000 32.22230 ? 10  GLU A CB  1 
ATOM   79   C CG  . GLU A 1 15  ? -34.86960 40.17056 7.45445   1.000 37.27089 ? 10  GLU A CG  1 
ATOM   80   C CD  . GLU A 1 15  ? -35.03878 41.68757 7.35941   1.000 47.96342 ? 10  GLU A CD  1 
ATOM   81   O OE1 . GLU A 1 15  ? -34.09201 42.38490 6.91459   1.000 41.49330 ? 10  GLU A OE1 1 
ATOM   82   O OE2 . GLU A 1 15  ? -36.12569 42.18242 7.73632   1.000 49.84510 ? 10  GLU A OE2 1 
ATOM   83   N N   . ILE A 1 16  ? -30.20409 39.59755 7.75378   1.000 27.10657 ? 11  ILE A N   1 
ATOM   84   C CA  . ILE A 1 16  ? -28.94849 38.85144 7.65273   1.000 27.25738 ? 11  ILE A CA  1 
ATOM   85   C C   . ILE A 1 16  ? -28.32657 38.68208 9.02820   1.000 26.67498 ? 11  ILE A C   1 
ATOM   86   O O   . ILE A 1 16  ? -27.85867 37.59267 9.38139   1.000 26.70629 ? 11  ILE A O   1 
ATOM   87   C CB  . ILE A 1 16  ? -27.98260 39.52882 6.66307   1.000 28.16863 ? 11  ILE A CB  1 
ATOM   88   C CG1 . ILE A 1 16  ? -28.62199 39.60467 5.27789   1.000 28.77511 ? 11  ILE A CG1 1 
ATOM   89   C CG2 . ILE A 1 16  ? -26.64540 38.75312 6.59037   1.000 26.40674 ? 11  ILE A CG2 1 
ATOM   90   C CD1 . ILE A 1 16  ? -27.84583 40.46705 4.30399   1.000 37.24702 ? 11  ILE A CD1 1 
ATOM   91   N N   . THR A 1 17  ? -28.33668 39.74385 9.84042   1.000 25.14076 ? 12  THR A N   1 
ATOM   92   C CA  . THR A 1 17  ? -27.86942 39.61947 11.21589  1.000 28.00118 ? 12  THR A CA  1 
ATOM   93   C C   . THR A 1 17  ? -28.64784 38.54613 11.96349  1.000 27.60547 ? 12  THR A C   1 
ATOM   94   O O   . THR A 1 17  ? -28.05886 37.73442 12.68399  1.000 28.22135 ? 12  THR A O   1 
ATOM   95   C CB  . THR A 1 17  ? -27.99279 40.96260 11.93817  1.000 32.08193 ? 12  THR A CB  1 
ATOM   96   O OG1 . THR A 1 17  ? -27.10826 41.90645 11.33581  1.000 37.74476 ? 12  THR A OG1 1 
ATOM   97   C CG2 . THR A 1 17  ? -27.62574 40.81442 13.39170  1.000 36.01774 ? 12  THR A CG2 1 
ATOM   98   N N   . GLN A 1 18  ? -29.97534 38.52351 11.79271  1.000 29.84780 ? 13  GLN A N   1 
ATOM   99   C CA  . GLN A 1 18  ? -30.80025 37.51566 12.45424  1.000 28.60337 ? 13  GLN A CA  1 
ATOM   100  C C   . GLN A 1 18  ? -30.38487 36.11591 12.03144  1.000 29.95769 ? 13  GLN A C   1 
ATOM   101  O O   . GLN A 1 18  ? -30.26120 35.21012 12.86365  1.000 28.88324 ? 13  GLN A O   1 
ATOM   102  C CB  . GLN A 1 18  ? -32.27766 37.74237 12.12639  1.000 32.16229 ? 13  GLN A CB  1 
ATOM   103  C CG  . GLN A 1 18  ? -32.79206 39.10218 12.52645  1.000 36.72106 ? 13  GLN A CG  1 
ATOM   104  C CD  . GLN A 1 18  ? -34.10752 39.46844 11.85724  1.000 43.60779 ? 13  GLN A CD  1 
ATOM   105  O OE1 . GLN A 1 18  ? -34.93361 38.59840 11.55468  1.000 41.79283 ? 13  GLN A OE1 1 
ATOM   106  N NE2 . GLN A 1 18  ? -34.30622 40.76844 11.61816  1.000 42.28436 ? 13  GLN A NE2 1 
ATOM   107  N N   . LEU A 1 19  ? -30.16062 35.92216 10.73326  1.000 26.67601 ? 14  LEU A N   1 
ATOM   108  C CA  . LEU A 1 19  ? -29.77272 34.59803 10.26436  1.000 26.90787 ? 14  LEU A CA  1 
ATOM   109  C C   . LEU A 1 19  ? -28.40592 34.19518 10.80915  1.000 29.68471 ? 14  LEU A C   1 
ATOM   110  O O   . LEU A 1 19  ? -28.22774 33.06392 11.27500  1.000 29.01981 ? 14  LEU A O   1 
ATOM   111  C CB  . LEU A 1 19  ? -29.78997 34.56182 8.73899   1.000 27.46860 ? 14  LEU A CB  1 
ATOM   112  C CG  . LEU A 1 19  ? -29.35177 33.21399 8.16135   1.000 28.74287 ? 14  LEU A CG  1 
ATOM   113  C CD1 . LEU A 1 19  ? -30.28261 32.10435 8.64066   1.000 31.12635 ? 14  LEU A CD1 1 
ATOM   114  C CD2 . LEU A 1 19  ? -29.31138 33.28277 6.64515   1.000 33.09959 ? 14  LEU A CD2 1 
ATOM   115  N N   . MET A 1 20  ? -27.42942 35.11064 10.78095  1.000 29.16333 ? 15  MET A N   1 
ATOM   116  C CA  . MET A 1 20  ? -26.09108 34.76593 11.26294  1.000 27.84774 ? 15  MET A CA  1 
ATOM   117  C C   . MET A 1 20  ? -26.10368 34.42916 12.74473  1.000 35.11086 ? 15  MET A C   1 
ATOM   118  O O   . MET A 1 20  ? -25.43112 33.48880 13.17855  1.000 35.10585 ? 15  MET A O   1 
ATOM   119  C CB  . MET A 1 20  ? -25.10804 35.90469 11.00235  1.000 30.23881 ? 15  MET A CB  1 
ATOM   120  C CG  . MET A 1 20  ? -24.72122 36.03990 9.55986   1.000 29.10226 ? 15  MET A CG  1 
ATOM   121  S SD  . MET A 1 20  ? -23.54802 37.37548 9.30932   1.000 29.90468 ? 15  MET A SD  1 
ATOM   122  C CE  . MET A 1 20  ? -24.43536 38.77410 10.00514  1.000 31.28486 ? 15  MET A CE  1 
ATOM   123  N N   . SER A 1 21  ? -26.84501 35.19887 13.54376  1.000 33.37912 ? 16  SER A N   1 
ATOM   124  C CA  . SER A 1 21  ? -26.90122 34.90248 14.97033  1.000 39.01961 ? 16  SER A CA  1 
ATOM   125  C C   . SER A 1 21  ? -27.49879 33.52429 15.20859  1.000 35.19522 ? 16  SER A C   1 
ATOM   126  O O   . SER A 1 21  ? -26.99338 32.74487 16.02931  1.000 36.36033 ? 16  SER A O   1 
ATOM   127  C CB  . SER A 1 21  ? -27.70872 35.97401 15.70386  1.000 41.57626 ? 16  SER A CB  1 
ATOM   128  O OG  . SER A 1 21  ? -27.54233 35.84754 17.10770  1.000 43.92714 ? 16  SER A OG  1 
ATOM   129  N N   . LEU A 1 22  ? -28.56889 33.20308 14.48745  1.000 36.24834 ? 17  LEU A N   1 
ATOM   130  C CA  . LEU A 1 22  ? -29.14160 31.86854 14.57138  1.000 36.29889 ? 17  LEU A CA  1 
ATOM   131  C C   . LEU A 1 22  ? -28.09081 30.79823 14.27879  1.000 39.23772 ? 17  LEU A C   1 
ATOM   132  O O   . LEU A 1 22  ? -27.89246 29.87346 15.07573  1.000 36.52582 ? 17  LEU A O   1 
ATOM   133  C CB  . LEU A 1 22  ? -30.31707 31.77067 13.60170  1.000 30.76842 ? 17  LEU A CB  1 
ATOM   134  C CG  . LEU A 1 22  ? -31.34210 30.66901 13.82384  1.000 42.42891 ? 17  LEU A CG  1 
ATOM   135  C CD1 . LEU A 1 22  ? -32.61903 31.00166 13.06268  1.000 41.91595 ? 17  LEU A CD1 1 
ATOM   136  C CD2 . LEU A 1 22  ? -30.77748 29.31942 13.38654  1.000 42.51249 ? 17  LEU A CD2 1 
ATOM   137  N N   . ILE A 1 23  ? -27.38951 30.92083 13.14782  1.000 32.75824 ? 18  ILE A N   1 
ATOM   138  C CA  . ILE A 1 23  ? -26.48649 29.85288 12.71892  1.000 30.40649 ? 18  ILE A CA  1 
ATOM   139  C C   . ILE A 1 23  ? -25.25540 29.77249 13.62089  1.000 35.01607 ? 18  ILE A C   1 
ATOM   140  O O   . ILE A 1 23  ? -24.76449 28.67239 13.91562  1.000 32.91261 ? 18  ILE A O   1 
ATOM   141  C CB  . ILE A 1 23  ? -26.09244 30.04340 11.23815  1.000 29.07780 ? 18  ILE A CB  1 
ATOM   142  C CG1 . ILE A 1 23  ? -27.30563 29.86327 10.31959  1.000 26.44808 ? 18  ILE A CG1 1 
ATOM   143  C CG2 . ILE A 1 23  ? -24.95921 29.07519 10.83434  1.000 26.99302 ? 18  ILE A CG2 1 
ATOM   144  C CD1 . ILE A 1 23  ? -27.05772 30.33801 8.86895   1.000 27.10190 ? 18  ILE A CD1 1 
ATOM   145  N N   . ILE A 1 24  ? -24.69481 30.92102 14.02893  1.000 34.77232 ? 19  ILE A N   1 
ATOM   146  C CA  . ILE A 1 24  ? -23.47364 30.86814 14.83412  1.000 32.84787 ? 19  ILE A CA  1 
ATOM   147  C C   . ILE A 1 24  ? -23.76412 30.34268 16.23924  1.000 39.02281 ? 19  ILE A C   1 
ATOM   148  O O   . ILE A 1 24  ? -22.85446 29.84161 16.91711  1.000 35.36528 ? 19  ILE A O   1 
ATOM   149  C CB  . ILE A 1 24  ? -22.75606 32.23826 14.88975  1.000 30.90228 ? 19  ILE A CB  1 
ATOM   150  C CG1 . ILE A 1 24  ? -21.27805 32.04801 15.27981  1.000 37.12159 ? 19  ILE A CG1 1 
ATOM   151  C CG2 . ILE A 1 24  ? -23.43703 33.18650 15.87779  1.000 36.79412 ? 19  ILE A CG2 1 
ATOM   152  C CD1 . ILE A 1 24  ? -20.44023 33.33741 15.27681  1.000 39.45265 ? 19  ILE A CD1 1 
ATOM   153  N N   . ASN A 1 25  ? -25.01763 30.40458 16.68412  1.000 37.45538 ? 20  ASN A N   1 
ATOM   154  C CA  . ASN A 1 25  ? -25.38379 29.91880 18.00799  1.000 37.75003 ? 20  ASN A CA  1 
ATOM   155  C C   . ASN A 1 25  ? -26.02011 28.53805 17.99678  1.000 40.56078 ? 20  ASN A C   1 
ATOM   156  O O   . ASN A 1 25  ? -26.16189 27.93398 19.06841  1.000 35.84674 ? 20  ASN A O   1 
ATOM   157  C CB  . ASN A 1 25  ? -26.35161 30.90313 18.69305  1.000 38.89598 ? 20  ASN A CB  1 
ATOM   158  C CG  . ASN A 1 25  ? -25.67036 32.18140 19.11061  1.000 43.54148 ? 20  ASN A CG  1 
ATOM   159  O OD1 . ASN A 1 25  ? -26.06828 33.27460 18.70770  1.000 46.54727 ? 20  ASN A OD1 1 
ATOM   160  N ND2 . ASN A 1 25  ? -24.62048 32.05075 19.91350  1.000 41.11846 ? 20  ASN A ND2 1 
ATOM   161  N N   . THR A 1 26  ? -26.41518 28.02319 16.83618  1.000 36.45304 ? 21  THR A N   1 
ATOM   162  C CA  . THR A 1 26  ? -27.24211 26.82467 16.83226  1.000 35.65742 ? 21  THR A CA  1 
ATOM   163  C C   . THR A 1 26  ? -26.45093 25.59415 17.25434  1.000 37.45016 ? 21  THR A C   1 
ATOM   164  O O   . THR A 1 26  ? -25.25894 25.46177 16.97436  1.000 39.04294 ? 21  THR A O   1 
ATOM   165  C CB  . THR A 1 26  ? -27.86541 26.59582 15.45407  1.000 37.45048 ? 21  THR A CB  1 
ATOM   166  O OG1 . THR A 1 26  ? -28.71341 25.44133 15.49517  1.000 34.75286 ? 21  THR A OG1 1 
ATOM   167  C CG2 . THR A 1 26  ? -26.79942 26.37236 14.40353  1.000 37.36722 ? 21  THR A CG2 1 
ATOM   168  N N   . VAL A 1 27  ? -27.13397 24.68644 17.94672  1.000 37.60965 ? 22  VAL A N   1 
ATOM   169  C CA  . VAL A 1 27  ? -26.57354 23.38234 18.28668  1.000 36.72105 ? 22  VAL A CA  1 
ATOM   170  C C   . VAL A 1 27  ? -26.92905 22.33176 17.23063  1.000 39.15727 ? 22  VAL A C   1 
ATOM   171  O O   . VAL A 1 27  ? -26.81698 21.12655 17.48979  1.000 36.49347 ? 22  VAL A O   1 
ATOM   172  C CB  . VAL A 1 27  ? -27.00348 22.92596 19.69029  1.000 37.75759 ? 22  VAL A CB  1 
ATOM   173  C CG1 . VAL A 1 27  ? -26.40798 23.85201 20.74538  1.000 38.35886 ? 22  VAL A CG1 1 
ATOM   174  C CG2 . VAL A 1 27  ? -28.52293 22.88031 19.79609  1.000 36.22872 ? 22  VAL A CG2 1 
ATOM   175  N N   . TYR A 1 28  ? -27.36628 22.77712 16.04882  1.000 37.97049 ? 23  TYR A N   1 
ATOM   176  C CA  . TYR A 1 28  ? -27.64276 21.87295 14.94473  1.000 38.59440 ? 23  TYR A CA  1 
ATOM   177  C C   . TYR A 1 28  ? -26.53487 20.83454 14.81947  1.000 37.36511 ? 23  TYR A C   1 
ATOM   178  O O   . TYR A 1 28  ? -25.34506 21.13966 14.96331  1.000 37.54454 ? 23  TYR A O   1 
ATOM   179  C CB  . TYR A 1 28  ? -27.78833 22.66433 13.63885  1.000 39.67968 ? 23  TYR A CB  1 
ATOM   180  C CG  . TYR A 1 28  ? -27.94072 21.79435 12.40724  1.000 37.06782 ? 23  TYR A CG  1 
ATOM   181  C CD1 . TYR A 1 28  ? -29.12372 21.10665 12.16128  1.000 31.92693 ? 23  TYR A CD1 1 
ATOM   182  C CD2 . TYR A 1 28  ? -26.90266 21.66708 11.48411  1.000 37.11049 ? 23  TYR A CD2 1 
ATOM   183  C CE1 . TYR A 1 28  ? -29.27549 20.31350 11.03134  1.000 33.25032 ? 23  TYR A CE1 1 
ATOM   184  C CE2 . TYR A 1 28  ? -27.04323 20.87572 10.35350  1.000 32.67658 ? 23  TYR A CE2 1 
ATOM   185  C CZ  . TYR A 1 28  ? -28.23098 20.20212 10.12906  1.000 31.97908 ? 23  TYR A CZ  1 
ATOM   186  O OH  . TYR A 1 28  ? -28.37443 19.41600 9.00757   1.000 35.07324 ? 23  TYR A OH  1 
ATOM   187  N N   . SER A 1 29  ? -26.94090 19.59350 14.57683  1.000 32.49316 ? 24  SER A N   1 
ATOM   188  C CA  . SER A 1 29  ? -26.01670 18.47058 14.69470  1.000 36.41012 ? 24  SER A CA  1 
ATOM   189  C C   . SER A 1 29  ? -25.02739 18.38680 13.52980  1.000 40.16858 ? 24  SER A C   1 
ATOM   190  O O   . SER A 1 29  ? -23.84492 18.08674 13.74334  1.000 46.67081 ? 24  SER A O   1 
ATOM   191  C CB  . SER A 1 29  ? -26.81066 17.17013 14.80429  1.000 39.66088 ? 24  SER A CB  1 
ATOM   192  O OG  . SER A 1 29  ? -27.68726 17.05077 13.69276  1.000 47.72441 ? 24  SER A OG  1 
ATOM   193  N N   . ASN A 1 30  ? -25.48409 18.62762 12.29906  1.000 34.18490 ? 25  ASN A N   1 
ATOM   194  C CA  . ASN A 1 30  ? -24.71159 18.28491 11.09792  1.000 34.49397 ? 25  ASN A CA  1 
ATOM   195  C C   . ASN A 1 30  ? -23.94701 19.49533 10.56218  1.000 30.03620 ? 25  ASN A C   1 
ATOM   196  O O   . ASN A 1 30  ? -24.20192 19.98872 9.46138   1.000 29.65279 ? 25  ASN A O   1 
ATOM   197  C CB  . ASN A 1 30  ? -25.63190 17.70649 10.03048  1.000 36.45836 ? 25  ASN A CB  1 
ATOM   198  C CG  . ASN A 1 30  ? -26.41031 16.51295 10.53401  1.000 43.27007 ? 25  ASN A CG  1 
ATOM   199  O OD1 . ASN A 1 30  ? -25.88451 15.69818 11.29709  1.000 44.49539 ? 25  ASN A OD1 1 
ATOM   200  N ND2 . ASN A 1 30  ? -27.67769 16.41306 10.13171  1.000 44.50774 ? 25  ASN A ND2 1 
ATOM   201  N N   . LYS A 1 31  ? -22.98280 19.96511 11.35865  1.000 33.06663 ? 26  LYS A N   1 
ATOM   202  C CA  . LYS A 1 31  ? -22.23592 21.16428 10.98190  1.000 28.84757 ? 26  LYS A CA  1 
ATOM   203  C C   . LYS A 1 31  ? -21.43280 20.97522 9.69354   1.000 30.70200 ? 26  LYS A C   1 
ATOM   204  O O   . LYS A 1 31  ? -21.11997 21.96880 9.02541   1.000 27.41681 ? 26  LYS A O   1 
ATOM   205  C CB  . LYS A 1 31  ? -21.31055 21.57182 12.13143  1.000 32.83419 ? 26  LYS A CB  1 
ATOM   206  C CG  . LYS A 1 31  ? -22.05901 22.05157 13.38636  1.000 34.47974 ? 26  LYS A CG  1 
ATOM   207  C CD  . LYS A 1 31  ? -21.07832 22.35979 14.51104  1.000 35.79704 ? 26  LYS A CD  1 
ATOM   208  C CE  . LYS A 1 31  ? -21.76872 22.95995 15.74603  1.000 43.88841 ? 26  LYS A CE  1 
ATOM   209  N NZ  . LYS A 1 31  ? -21.98908 24.43826 15.62261  1.000 36.63115 ? 26  LYS A NZ  1 
ATOM   210  N N   . GLU A 1 32  ? -21.11443 19.72733 9.31719   1.000 29.29472 ? 27  GLU A N   1 
ATOM   211  C CA  . GLU A 1 32  ? -20.26069 19.47108 8.15367   1.000 28.32498 ? 27  GLU A CA  1 
ATOM   212  C C   . GLU A 1 32  ? -20.87631 19.93737 6.84309   1.000 25.52096 ? 27  GLU A C   1 
ATOM   213  O O   . GLU A 1 32  ? -20.16006 20.00433 5.83544   1.000 25.24842 ? 27  GLU A O   1 
ATOM   214  C CB  . GLU A 1 32  ? -19.94397 17.98024 8.02510   1.000 27.95639 ? 27  GLU A CB  1 
ATOM   215  C CG  . GLU A 1 32  ? -21.11516 17.14175 7.55341   1.000 30.86836 ? 27  GLU A CG  1 
ATOM   216  C CD  . GLU A 1 32  ? -20.81486 15.65875 7.64420   1.000 35.36655 ? 27  GLU A CD  1 
ATOM   217  O OE1 . GLU A 1 32  ? -20.22182 15.24418 8.66611   1.000 35.01266 ? 27  GLU A OE1 1 
ATOM   218  O OE2 . GLU A 1 32  ? -21.15530 14.92455 6.69520   1.000 33.39738 ? 27  GLU A OE2 1 
ATOM   219  N N   . ILE A 1 33  ? -22.17885 20.23614 6.81439   1.000 25.30105 ? 28  ILE A N   1 
ATOM   220  C CA  . ILE A 1 33  ? -22.81408 20.66681 5.57043   1.000 24.64063 ? 28  ILE A CA  1 
ATOM   221  C C   . ILE A 1 33  ? -22.20095 21.94841 5.02002   1.000 23.43363 ? 28  ILE A C   1 
ATOM   222  O O   . ILE A 1 33  ? -22.40147 22.26380 3.83842   1.000 25.06217 ? 28  ILE A O   1 
ATOM   223  C CB  . ILE A 1 33  ? -24.33570 20.86615 5.77103   1.000 27.88625 ? 28  ILE A CB  1 
ATOM   224  C CG1 . ILE A 1 33  ? -24.57716 21.96130 6.81133   1.000 29.75816 ? 28  ILE A CG1 1 
ATOM   225  C CG2 . ILE A 1 33  ? -24.99618 19.55010 6.15714   1.000 27.31031 ? 28  ILE A CG2 1 
ATOM   226  C CD1 . ILE A 1 33  ? -25.93665 22.61956 6.73766   1.000 34.35099 ? 28  ILE A CD1 1 
ATOM   227  N N   . PHE A 1 34  ? -21.47034 22.70882 5.84524   1.000 22.84442 ? 29  PHE A N   1 
ATOM   228  C CA  . PHE A 1 34  ? -20.92601 23.98180 5.36894   1.000 23.36486 ? 29  PHE A CA  1 
ATOM   229  C C   . PHE A 1 34  ? -19.99989 23.76427 4.18763   1.000 23.63725 ? 29  PHE A C   1 
ATOM   230  O O   . PHE A 1 34  ? -19.94308 24.60177 3.28277   1.000 23.22372 ? 29  PHE A O   1 
ATOM   231  C CB  . PHE A 1 34  ? -20.16901 24.71064 6.48036   1.000 24.73188 ? 29  PHE A CB  1 
ATOM   232  C CG  . PHE A 1 34  ? -18.76324 24.20733 6.68294   1.000 24.71568 ? 29  PHE A CG  1 
ATOM   233  C CD1 . PHE A 1 34  ? -18.52723 23.05330 7.42147   1.000 23.48097 ? 29  PHE A CD1 1 
ATOM   234  C CD2 . PHE A 1 34  ? -17.67515 24.88625 6.13143   1.000 21.41758 ? 29  PHE A CD2 1 
ATOM   235  C CE1 . PHE A 1 34  ? -17.23557 22.58766 7.60470   1.000 26.14119 ? 29  PHE A CE1 1 
ATOM   236  C CE2 . PHE A 1 34  ? -16.38202 24.42545 6.31101   1.000 22.82785 ? 29  PHE A CE2 1 
ATOM   237  C CZ  . PHE A 1 34  ? -16.16355 23.27054 7.05060   1.000 28.37362 ? 29  PHE A CZ  1 
ATOM   238  N N   . LEU A 1 35  ? -19.27511 22.64296 4.17963   1.000 23.32209 ? 30  LEU A N   1 
ATOM   239  C CA  . LEU A 1 35  ? -18.30601 22.39385 3.12401   1.000 24.34267 ? 30  LEU A CA  1 
ATOM   240  C C   . LEU A 1 35  ? -18.99869 22.19681 1.78143   1.000 23.31667 ? 30  LEU A C   1 
ATOM   241  O O   . LEU A 1 35  ? -18.56685 22.75591 0.77327   1.000 23.66209 ? 30  LEU A O   1 
ATOM   242  C CB  . LEU A 1 35  ? -17.45295 21.17765 3.49747   1.000 25.55571 ? 30  LEU A CB  1 
ATOM   243  C CG  . LEU A 1 35  ? -16.04385 21.06639 2.91919   1.000 35.71418 ? 30  LEU A CG  1 
ATOM   244  C CD1 . LEU A 1 35  ? -15.33454 22.40880 2.93349   1.000 31.82803 ? 30  LEU A CD1 1 
ATOM   245  C CD2 . LEU A 1 35  ? -15.26057 20.05828 3.74530   1.000 37.42274 ? 30  LEU A CD2 1 
ATOM   246  N N   . ARG A 1 36  ? -20.08105 21.41586 1.75406   1.000 20.38865 ? 31  ARG A N   1 
ATOM   247  C CA  . ARG A 1 36  ? -20.87022 21.27536 0.53484   1.000 22.29530 ? 31  ARG A CA  1 
ATOM   248  C C   . ARG A 1 36  ? -21.36991 22.62490 0.02921   1.000 19.52328 ? 31  ARG A C   1 
ATOM   249  O O   . ARG A 1 36  ? -21.30940 22.91333 -1.17474  1.000 20.42110 ? 31  ARG A O   1 
ATOM   250  C CB  . ARG A 1 36  ? -22.06017 20.35598 0.80164   1.000 24.09822 ? 31  ARG A CB  1 
ATOM   251  C CG  . ARG A 1 36  ? -22.96949 20.18489 -0.38712  1.000 27.47979 ? 31  ARG A CG  1 
ATOM   252  C CD  . ARG A 1 36  ? -24.26070 19.48856 0.03326   1.000 30.55162 ? 31  ARG A CD  1 
ATOM   253  N NE  . ARG A 1 36  ? -24.96499 18.93222 -1.11347  1.000 31.85249 ? 31  ARG A NE  1 
ATOM   254  C CZ  . ARG A 1 36  ? -26.01137 18.12196 -1.02660  1.000 38.06203 ? 31  ARG A CZ  1 
ATOM   255  N NH1 . ARG A 1 36  ? -26.51973 17.77043 0.14699   1.000 34.60181 ? 31  ARG A NH1 1 
ATOM   256  N NH2 . ARG A 1 36  ? -26.55888 17.65039 -2.14450  1.000 38.06848 ? 31  ARG A NH2 1 
ATOM   257  N N   . GLU A 1 37  ? -21.87443 23.46681 0.93148   1.000 20.89320 ? 32  GLU A N   1 
ATOM   258  C CA  . GLU A 1 37  ? -22.43794 24.74386 0.49745   1.000 19.02078 ? 32  GLU A CA  1 
ATOM   259  C C   . GLU A 1 37  ? -21.36505 25.67479 -0.04729  1.000 20.37151 ? 32  GLU A C   1 
ATOM   260  O O   . GLU A 1 37  ? -21.61525 26.42822 -0.99235  1.000 22.75489 ? 32  GLU A O   1 
ATOM   261  C CB  . GLU A 1 37  ? -23.17045 25.40847 1.66163   1.000 22.70568 ? 32  GLU A CB  1 
ATOM   262  C CG  . GLU A 1 37  ? -24.34839 24.60111 2.17772   1.000 22.00074 ? 32  GLU A CG  1 
ATOM   263  C CD  . GLU A 1 37  ? -25.36650 24.29664 1.08638   1.000 29.29238 ? 32  GLU A CD  1 
ATOM   264  O OE1 . GLU A 1 37  ? -25.53947 25.13040 0.17414   1.000 30.70362 ? 32  GLU A OE1 1 
ATOM   265  O OE2 . GLU A 1 37  ? -25.99120 23.21639 1.13067   1.000 31.34440 ? 32  GLU A OE2 1 
ATOM   266  N N   . LEU A 1 38  ? -20.18832 25.69608 0.58233   1.000 19.12615 ? 33  LEU A N   1 
ATOM   267  C CA  . LEU A 1 38  ? -19.13099 26.59368 0.12742   1.000 19.24963 ? 33  LEU A CA  1 
ATOM   268  C C   . LEU A 1 38  ? -18.51519 26.09558 -1.17803  1.000 19.28795 ? 33  LEU A C   1 
ATOM   269  O O   . LEU A 1 38  ? -18.16870 26.89473 -2.05575  1.000 19.83941 ? 33  LEU A O   1 
ATOM   270  C CB  . LEU A 1 38  ? -18.07198 26.75204 1.22240   1.000 19.18624 ? 33  LEU A CB  1 
ATOM   271  C CG  . LEU A 1 38  ? -18.57163 27.39508 2.52702   1.000 20.74444 ? 33  LEU A CG  1 
ATOM   272  C CD1 . LEU A 1 38  ? -17.44756 27.71232 3.50639   1.000 19.47446 ? 33  LEU A CD1 1 
ATOM   273  C CD2 . LEU A 1 38  ? -19.39646 28.65591 2.21750   1.000 22.00188 ? 33  LEU A CD2 1 
ATOM   274  N N   . ILE A 1 39  ? -18.38096 24.78027 -1.32492  1.000 18.73443 ? 34  ILE A N   1 
ATOM   275  C CA  . ILE A 1 39  ? -17.92425 24.21529 -2.59310  1.000 22.16377 ? 34  ILE A CA  1 
ATOM   276  C C   . ILE A 1 39  ? -18.93637 24.49470 -3.68764  1.000 21.36472 ? 34  ILE A C   1 
ATOM   277  O O   . ILE A 1 39  ? -18.56395 24.83179 -4.81506  1.000 18.51406 ? 34  ILE A O   1 
ATOM   278  C CB  . ILE A 1 39  ? -17.64932 22.70434 -2.44666  1.000 22.84999 ? 34  ILE A CB  1 
ATOM   279  C CG1 . ILE A 1 39  ? -16.44053 22.47410 -1.53932  1.000 21.34870 ? 34  ILE A CG1 1 
ATOM   280  C CG2 . ILE A 1 39  ? -17.37209 22.05167 -3.80999  1.000 23.48484 ? 34  ILE A CG2 1 
ATOM   281  C CD1 . ILE A 1 39  ? -16.19923 21.00924 -1.23398  1.000 23.49312 ? 34  ILE A CD1 1 
ATOM   282  N N   . SER A 1 40  ? -20.23481 24.36002 -3.37975  1.000 21.65027 ? 35  SER A N   1 
ATOM   283  C CA  . SER A 1 40  ? -21.26579 24.71078 -4.35703  1.000 20.82594 ? 35  SER A CA  1 
ATOM   284  C C   . SER A 1 40  ? -21.16842 26.17926 -4.77912  1.000 20.75418 ? 35  SER A C   1 
ATOM   285  O O   . SER A 1 40  ? -21.23501 26.49624 -5.97413  1.000 23.01972 ? 35  SER A O   1 
ATOM   286  C CB  . SER A 1 40  ? -22.65422 24.39776 -3.78016  1.000 22.69218 ? 35  SER A CB  1 
ATOM   287  O OG  . SER A 1 40  ? -23.67776 24.80145 -4.67001  1.000 26.79977 ? 35  SER A OG  1 
ATOM   288  N N   . ASN A 1 41  ? -21.00825 27.09926 -3.81668  1.000 20.64081 ? 36  ASN A N   1 
ATOM   289  C CA  . ASN A 1 41  ? -20.85308 28.50969 -4.18126  1.000 21.52633 ? 36  ASN A CA  1 
ATOM   290  C C   . ASN A 1 41  ? -19.59313 28.73882 -5.00635  1.000 22.57522 ? 36  ASN A C   1 
ATOM   291  O O   . ASN A 1 41  ? -19.59517 29.55373 -5.94143  1.000 21.40943 ? 36  ASN A O   1 
ATOM   292  C CB  . ASN A 1 41  ? -20.80157 29.39914 -2.93303  1.000 23.30878 ? 36  ASN A CB  1 
ATOM   293  C CG  . ASN A 1 41  ? -22.16875 29.60662 -2.30173  1.000 25.91912 ? 36  ASN A CG  1 
ATOM   294  O OD1 . ASN A 1 41  ? -23.13837 28.94569 -2.66107  1.000 23.16346 ? 36  ASN A OD1 1 
ATOM   295  N ND2 . ASN A 1 41  ? -22.24146 30.52134 -1.34425  1.000 30.49185 ? 36  ASN A ND2 1 
ATOM   296  N N   . ALA A 1 42  ? -18.49454 28.06323 -4.64720  1.000 19.42837 ? 37  ALA A N   1 
ATOM   297  C CA  . ALA A 1 42  ? -17.26437 28.17029 -5.42813  1.000 21.10065 ? 37  ALA A CA  1 
ATOM   298  C C   . ALA A 1 42  ? -17.49503 27.70833 -6.86195  1.000 22.26712 ? 37  ALA A C   1 
ATOM   299  O O   . ALA A 1 42  ? -17.07859 28.37386 -7.82047  1.000 18.50260 ? 37  ALA A O   1 
ATOM   300  C CB  . ALA A 1 42  ? -16.14195 27.33875 -4.78219  1.000 18.12959 ? 37  ALA A CB  1 
ATOM   301  N N   . SER A 1 43  ? -18.15243 26.55745 -7.02085  1.000 20.42997 ? 38  SER A N   1 
ATOM   302  C CA  . SER A 1 43  ? -18.42689 26.03604 -8.35970  1.000 21.72154 ? 38  SER A CA  1 
ATOM   303  C C   . SER A 1 43  ? -19.27340 27.01387 -9.17636  1.000 22.85005 ? 38  SER A C   1 
ATOM   304  O O   . SER A 1 43  ? -18.99423 27.24742 -10.35976 1.000 22.29032 ? 38  SER A O   1 
ATOM   305  C CB  . SER A 1 43  ? -19.11410 24.67243 -8.24769  1.000 21.44779 ? 38  SER A CB  1 
ATOM   306  O OG  . SER A 1 43  ? -19.42661 24.12739 -9.51466  1.000 24.09029 ? 38  SER A OG  1 
ATOM   307  N N   . ASP A 1 44  ? -20.29935 27.60902 -8.55964  1.000 21.78091 ? 39  ASP A N   1 
ATOM   308  C CA  . ASP A 1 44  ? -21.10536 28.60195 -9.27039  1.000 21.04287 ? 39  ASP A CA  1 
ATOM   309  C C   . ASP A 1 44  ? -20.25300 29.78202 -9.71775  1.000 21.84490 ? 39  ASP A C   1 
ATOM   310  O O   . ASP A 1 44  ? -20.45507 30.32807 -10.80700 1.000 22.35140 ? 39  ASP A O   1 
ATOM   311  C CB  . ASP A 1 44  ? -22.24306 29.11461 -8.38508  1.000 22.30976 ? 39  ASP A CB  1 
ATOM   312  C CG  . ASP A 1 44  ? -23.27310 28.04879 -8.05890  1.000 27.53045 ? 39  ASP A CG  1 
ATOM   313  O OD1 . ASP A 1 44  ? -23.31362 27.00365 -8.74115  1.000 27.50211 ? 39  ASP A OD1 1 
ATOM   314  O OD2 . ASP A 1 44  ? -24.04068 28.27045 -7.09521  1.000 29.80807 ? 39  ASP A OD2 1 
ATOM   315  N N   . ALA A 1 45  ? -19.31678 30.21832 -8.87154  1.000 20.37498 ? 40  ALA A N   1 
ATOM   316  C CA  . ALA A 1 45  ? -18.48924 31.36608 -9.22739  1.000 20.08581 ? 40  ALA A CA  1 
ATOM   317  C C   . ALA A 1 45  ? -17.59867 31.05053 -10.42177 1.000 19.46355 ? 40  ALA A C   1 
ATOM   318  O O   . ALA A 1 45  ? -17.30536 31.93994 -11.23494 1.000 19.70156 ? 40  ALA A O   1 
ATOM   319  C CB  . ALA A 1 45  ? -17.64483 31.80581 -8.02178  1.000 20.47000 ? 40  ALA A CB  1 
ATOM   320  N N   . ILE A 1 46  ? -17.10298 29.80570 -10.50564 1.000 19.08460 ? 41  ILE A N   1 
ATOM   321  C CA  . ILE A 1 46  ? -16.32332 29.38177 -11.66314 1.000 19.70184 ? 41  ILE A CA  1 
ATOM   322  C C   . ILE A 1 46  ? -17.21587 29.27417 -12.89990 1.000 20.86100 ? 41  ILE A C   1 
ATOM   323  O O   . ILE A 1 46  ? -16.81648 29.66356 -14.00434 1.000 19.86708 ? 41  ILE A O   1 
ATOM   324  C CB  . ILE A 1 46  ? -15.59828 28.05957 -11.36956 1.000 21.63808 ? 41  ILE A CB  1 
ATOM   325  C CG1 . ILE A 1 46  ? -14.61662 28.25326 -10.20476 1.000 17.93622 ? 41  ILE A CG1 1 
ATOM   326  C CG2 . ILE A 1 46  ? -14.82620 27.58701 -12.60427 1.000 23.49804 ? 41  ILE A CG2 1 
ATOM   327  C CD1 . ILE A 1 46  ? -14.01005 26.94635 -9.70646  1.000 20.13819 ? 41  ILE A CD1 1 
ATOM   328  N N   . ASP A 1 47  ? -18.43223 28.74893 -12.73452 1.000 21.64131 ? 42  ASP A N   1 
ATOM   329  C CA  . ASP A 1 47  ? -19.38568 28.73723 -13.84953 1.000 23.44347 ? 42  ASP A CA  1 
ATOM   330  C C   . ASP A 1 47  ? -19.51753 30.12375 -14.45646 1.000 21.74907 ? 42  ASP A C   1 
ATOM   331  O O   . ASP A 1 47  ? -19.55276 30.27377 -15.68442 1.000 18.96365 ? 42  ASP A O   1 
ATOM   332  C CB  . ASP A 1 47  ? -20.76551 28.26919 -13.38826 1.000 22.41230 ? 42  ASP A CB  1 
ATOM   333  C CG  . ASP A 1 47  ? -20.82473 26.79091 -13.06883 1.000 25.65832 ? 42  ASP A CG  1 
ATOM   334  O OD1 . ASP A 1 47  ? -19.86232 26.03489 -13.35045 1.000 24.08343 ? 42  ASP A OD1 1 
ATOM   335  O OD2 . ASP A 1 47  ? -21.86556 26.38308 -12.51805 1.000 25.73519 ? 42  ASP A OD2 1 
ATOM   336  N N   . LYS A 1 48  ? -19.58817 31.14718 -13.59903 1.000 22.36651 ? 43  LYS A N   1 
ATOM   337  C CA  . LYS A 1 48  ? -19.84130 32.51219 -14.04907 1.000 21.68635 ? 43  LYS A CA  1 
ATOM   338  C C   . LYS A 1 48  ? -18.70760 33.03959 -14.91088 1.000 23.30381 ? 43  LYS A C   1 
ATOM   339  O O   . LYS A 1 48  ? -18.94866 33.67142 -15.94367 1.000 23.28007 ? 43  LYS A O   1 
ATOM   340  C CB  . LYS A 1 48  ? -20.03671 33.44096 -12.85137 1.000 24.47166 ? 43  LYS A CB  1 
ATOM   341  C CG  . LYS A 1 48  ? -21.22187 33.12444 -11.95633 1.000 33.31041 ? 43  LYS A CG  1 
ATOM   342  C CD  . LYS A 1 48  ? -22.51658 33.16454 -12.70689 1.000 36.42112 ? 43  LYS A CD  1 
ATOM   343  C CE  . LYS A 1 48  ? -23.63267 33.70126 -11.80824 1.000 42.98461 ? 43  LYS A CE  1 
ATOM   344  N NZ  . LYS A 1 48  ? -23.56745 33.10277 -10.44407 1.000 44.08531 ? 43  LYS A NZ  1 
ATOM   345  N N   . ILE A 1 49  ? -17.45548 32.84199 -14.47733 1.000 23.84194 ? 44  ILE A N   1 
ATOM   346  C CA  . ILE A 1 49  ? -16.34632 33.39094 -15.25595 1.000 20.93099 ? 44  ILE A CA  1 
ATOM   347  C C   . ILE A 1 49  ? -16.18877 32.62843 -16.56242 1.000 22.74396 ? 44  ILE A C   1 
ATOM   348  O O   . ILE A 1 49  ? -15.87820 33.21969 -17.60620 1.000 20.85301 ? 44  ILE A O   1 
ATOM   349  C CB  . ILE A 1 49  ? -15.03327 33.42650 -14.44137 1.000 21.80238 ? 44  ILE A CB  1 
ATOM   350  C CG1 . ILE A 1 49  ? -13.95400 34.20135 -15.22054 1.000 24.71423 ? 44  ILE A CG1 1 
ATOM   351  C CG2 . ILE A 1 49  ? -14.53302 32.04145 -14.09313 1.000 20.01431 ? 44  ILE A CG2 1 
ATOM   352  C CD1 . ILE A 1 49  ? -14.24366 35.73905 -15.33824 1.000 24.29906 ? 44  ILE A CD1 1 
ATOM   353  N N   . ARG A 1 50  ? -16.43450 31.31690 -16.54103 1.000 20.28234 ? 45  ARG A N   1 
ATOM   354  C CA  . ARG A 1 50  ? -16.37412 30.55074 -17.78145 1.000 21.93124 ? 45  ARG A CA  1 
ATOM   355  C C   . ARG A 1 50  ? -17.43873 31.02634 -18.75735 1.000 24.57742 ? 45  ARG A C   1 
ATOM   356  O O   . ARG A 1 50  ? -17.19195 31.12332 -19.96552 1.000 22.35548 ? 45  ARG A O   1 
ATOM   357  C CB  . ARG A 1 50  ? -16.55403 29.06074 -17.51095 1.000 24.73060 ? 45  ARG A CB  1 
ATOM   358  C CG  . ARG A 1 50  ? -15.27363 28.32709 -17.19806 1.000 27.78381 ? 45  ARG A CG  1 
ATOM   359  C CD  . ARG A 1 50  ? -15.33456 26.89656 -17.75492 1.000 31.32703 ? 45  ARG A CD  1 
ATOM   360  N NE  . ARG A 1 50  ? -16.37743 26.16028 -17.07623 1.000 37.92637 ? 45  ARG A NE  1 
ATOM   361  C CZ  . ARG A 1 50  ? -17.19717 25.29746 -17.65415 1.000 32.45258 ? 45  ARG A CZ  1 
ATOM   362  N NH1 . ARG A 1 50  ? -17.10845 25.01388 -18.94385 1.000 38.97187 ? 45  ARG A NH1 1 
ATOM   363  N NH2 . ARG A 1 50  ? -18.13073 24.70910 -16.91823 1.000 36.97609 ? 45  ARG A NH2 1 
ATOM   364  N N   . TYR A 1 51  ? -18.62906 31.31975 -18.24612 1.000 20.36498 ? 46  TYR A N   1 
ATOM   365  C CA  . TYR A 1 51  ? -19.69742 31.78711 -19.11430 1.000 22.34812 ? 46  TYR A CA  1 
ATOM   366  C C   . TYR A 1 51  ? -19.39743 33.17548 -19.65603 1.000 24.08949 ? 46  TYR A C   1 
ATOM   367  O O   . TYR A 1 51  ? -19.58858 33.43405 -20.85147 1.000 21.99543 ? 46  TYR A O   1 
ATOM   368  C CB  . TYR A 1 51  ? -21.02176 31.77707 -18.36795 1.000 23.15252 ? 46  TYR A CB  1 
ATOM   369  C CG  . TYR A 1 51  ? -22.18919 31.87737 -19.31331 1.000 28.45787 ? 46  TYR A CG  1 
ATOM   370  C CD1 . TYR A 1 51  ? -22.77228 30.73397 -19.85529 1.000 28.63089 ? 46  TYR A CD1 1 
ATOM   371  C CD2 . TYR A 1 51  ? -22.69081 33.11752 -19.69010 1.000 30.14235 ? 46  TYR A CD2 1 
ATOM   372  C CE1 . TYR A 1 51  ? -23.84209 30.83168 -20.73457 1.000 31.43174 ? 46  TYR A CE1 1 
ATOM   373  C CE2 . TYR A 1 51  ? -23.75379 33.21912 -20.56562 1.000 33.37950 ? 46  TYR A CE2 1 
ATOM   374  C CZ  . TYR A 1 51  ? -24.32434 32.07948 -21.07287 1.000 29.60460 ? 46  TYR A CZ  1 
ATOM   375  O OH  . TYR A 1 51  ? -25.38852 32.20485 -21.93570 1.000 41.54445 ? 46  TYR A OH  1 
ATOM   376  N N   . GLN A 1 52  ? -18.92265 34.08313 -18.79828 1.000 24.38561 ? 47  GLN A N   1 
ATOM   377  C CA  . GLN A 1 52  ? -18.51921 35.39107 -19.30280 1.000 24.84339 ? 47  GLN A CA  1 
ATOM   378  C C   . GLN A 1 52  ? -17.47249 35.23408 -20.38929 1.000 27.10091 ? 47  GLN A C   1 
ATOM   379  O O   . GLN A 1 52  ? -17.51578 35.92818 -21.41520 1.000 27.26466 ? 47  GLN A O   1 
ATOM   380  C CB  . GLN A 1 52  ? -17.98370 36.27762 -18.16582 1.000 26.53677 ? 47  GLN A CB  1 
ATOM   381  C CG  . GLN A 1 52  ? -17.70596 37.71106 -18.61509 1.000 28.96836 ? 47  GLN A CG  1 
ATOM   382  C CD  . GLN A 1 52  ? -17.06232 38.55671 -17.53434 1.000 32.13301 ? 47  GLN A CD  1 
ATOM   383  O OE1 . GLN A 1 52  ? -17.06894 38.18982 -16.36561 1.000 34.95556 ? 47  GLN A OE1 1 
ATOM   384  N NE2 . GLN A 1 52  ? -16.49903 39.69349 -17.92363 1.000 35.26021 ? 47  GLN A NE2 1 
ATOM   385  N N   . ALA A 1 53  ? -16.53543 34.29803 -20.19974 1.000 24.15060 ? 48  ALA A N   1 
ATOM   386  C CA  . ALA A 1 53  ? -15.44526 34.14371 -21.15112 1.000 25.41516 ? 48  ALA A CA  1 
ATOM   387  C C   . ALA A 1 53  ? -15.87925 33.54042 -22.47900 1.000 25.50368 ? 48  ALA A C   1 
ATOM   388  O O   . ALA A 1 53  ? -15.07412 33.54250 -23.41772 1.000 26.96003 ? 48  ALA A O   1 
ATOM   389  C CB  . ALA A 1 53  ? -14.33092 33.28533 -20.55376 1.000 25.36379 ? 48  ALA A CB  1 
ATOM   390  N N   . LEU A 1 54  ? -17.10067 32.99884 -22.57494 1.000 23.15916 ? 49  LEU A N   1 
ATOM   391  C CA  . LEU A 1 54  ? -17.59438 32.51571 -23.86432 1.000 26.09170 ? 49  LEU A CA  1 
ATOM   392  C C   . LEU A 1 54  ? -17.54861 33.61788 -24.91500 1.000 26.57795 ? 49  LEU A C   1 
ATOM   393  O O   . LEU A 1 54  ? -17.23018 33.36472 -26.08186 1.000 27.82296 ? 49  LEU A O   1 
ATOM   394  C CB  . LEU A 1 54  ? -19.02303 31.99334 -23.73269 1.000 23.75184 ? 49  LEU A CB  1 
ATOM   395  C CG  . LEU A 1 54  ? -19.20634 30.67243 -23.00317 1.000 27.57901 ? 49  LEU A CG  1 
ATOM   396  C CD1 . LEU A 1 54  ? -20.69561 30.40685 -22.77589 1.000 25.86829 ? 49  LEU A CD1 1 
ATOM   397  C CD2 . LEU A 1 54  ? -18.55599 29.55209 -23.78442 1.000 28.51773 ? 49  LEU A CD2 1 
ATOM   398  N N   . SER A 1 55  ? -17.86298 34.84673 -24.51649 1.000 24.79003 ? 50  SER A N   1 
ATOM   399  C CA  . SER A 1 55  ? -17.87397 35.98706 -25.41845 1.000 27.31820 ? 50  SER A CA  1 
ATOM   400  C C   . SER A 1 55  ? -16.72206 36.94926 -25.16574 1.000 30.38531 ? 50  SER A C   1 
ATOM   401  O O   . SER A 1 55  ? -16.69477 38.03340 -25.75595 1.000 30.03459 ? 50  SER A O   1 
ATOM   402  C CB  . SER A 1 55  ? -19.20661 36.72874 -25.29462 1.000 28.51734 ? 50  SER A CB  1 
ATOM   403  O OG  . SER A 1 55  ? -20.24799 35.90478 -25.79962 1.000 34.80275 ? 50  SER A OG  1 
ATOM   404  N N   . ASP A 1 56  ? -15.78602 36.59618 -24.28822 1.000 25.74622 ? 51  ASP A N   1 
ATOM   405  C CA  . ASP A 1 56  ? -14.69652 37.50102 -23.92854 1.000 26.46532 ? 51  ASP A CA  1 
ATOM   406  C C   . ASP A 1 56  ? -13.58852 36.64644 -23.32599 1.000 27.21703 ? 51  ASP A C   1 
ATOM   407  O O   . ASP A 1 56  ? -13.34549 36.71033 -22.11391 1.000 27.47089 ? 51  ASP A O   1 
ATOM   408  C CB  . ASP A 1 56  ? -15.17885 38.57293 -22.95296 1.000 28.08874 ? 51  ASP A CB  1 
ATOM   409  C CG  . ASP A 1 56  ? -14.18382 39.73167 -22.78381 1.000 32.43467 ? 51  ASP A CG  1 
ATOM   410  O OD1 . ASP A 1 56  ? -13.10672 39.71147 -23.40972 1.000 35.04064 ? 51  ASP A OD1 1 
ATOM   411  O OD2 . ASP A 1 56  ? -14.49335 40.66484 -22.00892 1.000 31.15593 ? 51  ASP A OD2 1 
ATOM   412  N N   . PRO A 1 57  ? -12.91530 35.83106 -24.14206 1.000 30.16324 ? 52  PRO A N   1 
ATOM   413  C CA  . PRO A 1 57  ? -11.98679 34.83130 -23.58776 1.000 31.12882 ? 52  PRO A CA  1 
ATOM   414  C C   . PRO A 1 57  ? -10.86161 35.43292 -22.77419 1.000 30.10279 ? 52  PRO A C   1 
ATOM   415  O O   . PRO A 1 57  ? -10.34032 34.75567 -21.88121 1.000 27.27916 ? 52  PRO A O   1 
ATOM   416  C CB  . PRO A 1 57  ? -11.44839 34.10906 -24.83515 1.000 29.14718 ? 52  PRO A CB  1 
ATOM   417  C CG  . PRO A 1 57  ? -12.42136 34.40703 -25.92067 1.000 32.93908 ? 52  PRO A CG  1 
ATOM   418  C CD  . PRO A 1 57  ? -13.01013 35.75527 -25.61247 1.000 29.06977 ? 52  PRO A CD  1 
ATOM   419  N N   . LYS A 1 58  ? -10.47214 36.68137 -23.04392 1.000 26.77434 ? 53  LYS A N   1 
ATOM   420  C CA  . LYS A 1 58  ? -9.38025  37.27704 -22.28340 1.000 31.61429 ? 53  LYS A CA  1 
ATOM   421  C C   . LYS A 1 58  ? -9.70365  37.39379 -20.79893 1.000 31.75401 ? 53  LYS A C   1 
ATOM   422  O O   . LYS A 1 58  ? -8.78358  37.54200 -19.98828 1.000 30.15054 ? 53  LYS A O   1 
ATOM   423  C CB  . LYS A 1 58  ? -9.03131  38.65691 -22.83415 1.000 30.98743 ? 53  LYS A CB  1 
ATOM   424  C CG  . LYS A 1 58  ? -10.00731 39.73933 -22.39201 1.000 37.71655 ? 53  LYS A CG  1 
ATOM   425  C CD  . LYS A 1 58  ? -9.47449  41.14097 -22.65090 1.000 42.53717 ? 53  LYS A CD  1 
ATOM   426  C CE  . LYS A 1 58  ? -10.49151 42.18758 -22.21201 1.000 42.56009 ? 53  LYS A CE  1 
ATOM   427  N NZ  . LYS A 1 58  ? -11.76303 42.09002 -22.98082 1.000 49.40086 ? 53  LYS A NZ  1 
ATOM   428  N N   . GLN A 1 59  ? -10.98354 37.33274 -20.41841 1.000 25.71223 ? 54  GLN A N   1 
ATOM   429  C CA  . GLN A 1 59  ? -11.32349 37.41614 -19.00216 1.000 27.10409 ? 54  GLN A CA  1 
ATOM   430  C C   . GLN A 1 59  ? -10.75405 36.24532 -18.20646 1.000 28.63686 ? 54  GLN A C   1 
ATOM   431  O O   . GLN A 1 59  ? -10.55682 36.37264 -16.99033 1.000 25.86160 ? 54  GLN A O   1 
ATOM   432  C CB  . GLN A 1 59  ? -12.83981 37.48184 -18.82523 1.000 26.45435 ? 54  GLN A CB  1 
ATOM   433  C CG  . GLN A 1 59  ? -13.49350 38.68811 -19.48614 1.000 30.08115 ? 54  GLN A CG  1 
ATOM   434  C CD  . GLN A 1 59  ? -13.22964 39.98579 -18.74759 1.000 33.50893 ? 54  GLN A CD  1 
ATOM   435  O OE1 . GLN A 1 59  ? -12.98103 39.99396 -17.54065 1.000 29.65574 ? 54  GLN A OE1 1 
ATOM   436  N NE2 . GLN A 1 59  ? -13.28820 41.09641 -19.47397 1.000 33.04288 ? 54  GLN A NE2 1 
ATOM   437  N N   . LEU A 1 60  ? -10.47446 35.11762 -18.85971 1.000 23.30977 ? 55  LEU A N   1 
ATOM   438  C CA  . LEU A 1 60  ? -9.88489  33.98503 -18.15456 1.000 27.01671 ? 55  LEU A CA  1 
ATOM   439  C C   . LEU A 1 60  ? -8.39799  34.16008 -17.90794 1.000 26.07250 ? 55  LEU A C   1 
ATOM   440  O O   . LEU A 1 60  ? -7.84024  33.44788 -17.06165 1.000 28.93343 ? 55  LEU A O   1 
ATOM   441  C CB  . LEU A 1 60  ? -10.10247 32.68568 -18.93042 1.000 27.04700 ? 55  LEU A CB  1 
ATOM   442  C CG  . LEU A 1 60  ? -11.48840 32.03915 -18.83148 1.000 28.30055 ? 55  LEU A CG  1 
ATOM   443  C CD1 . LEU A 1 60  ? -11.59709 30.88596 -19.80771 1.000 34.64696 ? 55  LEU A CD1 1 
ATOM   444  C CD2 . LEU A 1 60  ? -11.79254 31.57159 -17.41335 1.000 28.89136 ? 55  LEU A CD2 1 
ATOM   445  N N   . GLU A 1 61  ? -7.75263  35.09431 -18.60946 1.000 30.17918 ? 56  GLU A N   1 
ATOM   446  C CA  . GLU A 1 61  ? -6.29332  35.14675 -18.61745 1.000 27.73102 ? 56  GLU A CA  1 
ATOM   447  C C   . GLU A 1 61  ? -5.70952  35.59723 -17.28972 1.000 29.71233 ? 56  GLU A C   1 
ATOM   448  O O   . GLU A 1 61  ? -4.52733  35.32945 -17.03324 1.000 27.92910 ? 56  GLU A O   1 
ATOM   449  C CB  . GLU A 1 61  ? -5.80897  36.05578 -19.74990 1.000 33.35473 ? 56  GLU A CB  1 
ATOM   450  C CG  . GLU A 1 61  ? -5.89032  35.38109 -21.11866 1.000 31.39990 ? 56  GLU A CG  1 
ATOM   451  C CD  . GLU A 1 61  ? -5.50431  36.31272 -22.27048 1.000 43.25221 ? 56  GLU A CD  1 
ATOM   452  O OE1 . GLU A 1 61  ? -4.87095  37.36198 -22.01629 1.000 42.23570 ? 56  GLU A OE1 1 
ATOM   453  O OE2 . GLU A 1 61  ? -5.84872  35.99767 -23.43224 1.000 45.26116 ? 56  GLU A OE2 1 
ATOM   454  N N   . THR A 1 62  ? -6.50437  36.25628 -16.43560 1.000 27.53885 ? 57  THR A N   1 
ATOM   455  C CA  . THR A 1 62  ? -6.01956  36.64127 -15.11286 1.000 27.54929 ? 57  THR A CA  1 
ATOM   456  C C   . THR A 1 62  ? -5.71916  35.42776 -14.23629 1.000 26.31658 ? 57  THR A C   1 
ATOM   457  O O   . THR A 1 62  ? -4.93504  35.53953 -13.28324 1.000 26.38335 ? 57  THR A O   1 
ATOM   458  C CB  . THR A 1 62  ? -7.04059  37.54817 -14.42328 1.000 24.20234 ? 57  THR A CB  1 
ATOM   459  O OG1 . THR A 1 62  ? -8.35236  36.97217 -14.52160 1.000 23.29763 ? 57  THR A OG1 1 
ATOM   460  C CG2 . THR A 1 62  ? -7.04723  38.93475 -15.05788 1.000 30.15953 ? 57  THR A CG2 1 
ATOM   461  N N   . GLU A 1 63  ? -6.34680  34.28621 -14.51972 1.000 24.60715 ? 58  GLU A N   1 
ATOM   462  C CA  . GLU A 1 63  ? -6.09563  33.01169 -13.85436 1.000 25.39001 ? 58  GLU A CA  1 
ATOM   463  C C   . GLU A 1 63  ? -6.67285  31.88629 -14.70248 1.000 25.02398 ? 58  GLU A C   1 
ATOM   464  O O   . GLU A 1 63  ? -7.84697  31.53429 -14.55350 1.000 24.02510 ? 58  GLU A O   1 
ATOM   465  C CB  . GLU A 1 63  ? -6.68662  32.98266 -12.44294 1.000 24.95239 ? 58  GLU A CB  1 
ATOM   466  C CG  . GLU A 1 63  ? -6.52565  31.63505 -11.75669 1.000 27.58044 ? 58  GLU A CG  1 
ATOM   467  C CD  . GLU A 1 63  ? -5.09525  31.11327 -11.81857 1.000 36.02738 ? 58  GLU A CD  1 
ATOM   468  O OE1 . GLU A 1 63  ? -4.77670  30.30987 -12.73146 1.000 32.89807 ? 58  GLU A OE1 1 
ATOM   469  O OE2 . GLU A 1 63  ? -4.29002  31.53125 -10.96318 1.000 36.70825 ? 58  GLU A OE2 1 
ATOM   470  N N   . PRO A 1 64  ? -5.89241  31.32505 -15.62412 1.000 25.41884 ? 59  PRO A N   1 
ATOM   471  C CA  . PRO A 1 64  ? -6.45617  30.34793 -16.56805 1.000 25.08774 ? 59  PRO A CA  1 
ATOM   472  C C   . PRO A 1 64  ? -6.80853  29.00020 -15.95470 1.000 29.85283 ? 59  PRO A C   1 
ATOM   473  O O   . PRO A 1 64  ? -7.56827  28.24788 -16.57534 1.000 27.83227 ? 59  PRO A O   1 
ATOM   474  C CB  . PRO A 1 64  ? -5.35975  30.21034 -17.64439 1.000 29.82106 ? 59  PRO A CB  1 
ATOM   475  C CG  . PRO A 1 64  ? -4.15978  30.89932 -17.11580 1.000 30.02674 ? 59  PRO A CG  1 
ATOM   476  C CD  . PRO A 1 64  ? -4.58679  31.85303 -16.05699 1.000 29.57650 ? 59  PRO A CD  1 
ATOM   477  N N   . GLU A 1 65  ? -6.29845  28.64912 -14.78375 1.000 24.04632 ? 60  GLU A N   1 
ATOM   478  C CA  . GLU A 1 65  ? -6.64602  27.36611 -14.17940 1.000 29.36485 ? 60  GLU A CA  1 
ATOM   479  C C   . GLU A 1 65  ? -7.91051  27.52152 -13.35347 1.000 27.11906 ? 60  GLU A C   1 
ATOM   480  O O   . GLU A 1 65  ? -8.00875  28.43954 -12.53411 1.000 25.97745 ? 60  GLU A O   1 
ATOM   481  C CB  . GLU A 1 65  ? -5.53497  26.83529 -13.28063 1.000 30.19852 ? 60  GLU A CB  1 
ATOM   482  C CG  . GLU A 1 65  ? -4.13642  26.93599 -13.85096 1.000 40.78383 ? 60  GLU A CG  1 
ATOM   483  C CD  . GLU A 1 65  ? -3.82802  25.95827 -14.97416 1.000 46.81548 ? 60  GLU A CD  1 
ATOM   484  O OE1 . GLU A 1 65  ? -4.41117  26.09468 -16.07246 1.000 52.18657 ? 60  GLU A OE1 1 
ATOM   485  O OE2 . GLU A 1 65  ? -2.97228  25.06608 -14.76131 1.000 52.87657 ? 60  GLU A OE2 1 
ATOM   486  N N   . LEU A 1 66  ? -8.85850  26.60949 -13.55111 1.000 26.91844 ? 61  LEU A N   1 
ATOM   487  C CA  . LEU A 1 66  ? -10.14732 26.64441 -12.86746 1.000 24.89140 ? 61  LEU A CA  1 
ATOM   488  C C   . LEU A 1 66  ? -10.16048 25.56689 -11.78978 1.000 24.90372 ? 61  LEU A C   1 
ATOM   489  O O   . LEU A 1 66  ? -10.08351 24.37773 -12.10040 1.000 25.39115 ? 61  LEU A O   1 
ATOM   490  C CB  . LEU A 1 66  ? -11.27291 26.43653 -13.87544 1.000 25.45228 ? 61  LEU A CB  1 
ATOM   491  C CG  . LEU A 1 66  ? -11.16189 27.43747 -15.02857 1.000 26.83886 ? 61  LEU A CG  1 
ATOM   492  C CD1 . LEU A 1 66  ? -12.20923 27.17192 -16.07867 1.000 32.48954 ? 61  LEU A CD1 1 
ATOM   493  C CD2 . LEU A 1 66  ? -11.22645 28.89385 -14.53978 1.000 26.85211 ? 61  LEU A CD2 1 
ATOM   494  N N   . PHE A 1 67  ? -10.23237 25.97561 -10.52463 1.000 21.52968 ? 62  PHE A N   1 
ATOM   495  C CA  . PHE A 1 67  ? -10.05301 24.99858 -9.46085  1.000 22.15932 ? 62  PHE A CA  1 
ATOM   496  C C   . PHE A 1 67  ? -10.75121 25.48312 -8.20309  1.000 21.19721 ? 62  PHE A C   1 
ATOM   497  O O   . PHE A 1 67  ? -10.99176 26.67670 -8.01888  1.000 21.12344 ? 62  PHE A O   1 
ATOM   498  C CB  . PHE A 1 67  ? -8.56283  24.76736 -9.15896  1.000 22.76355 ? 62  PHE A CB  1 
ATOM   499  C CG  . PHE A 1 67  ? -7.83547  26.02819 -8.76081  1.000 25.28819 ? 62  PHE A CG  1 
ATOM   500  C CD1 . PHE A 1 67  ? -7.77106  26.41914 -7.43061  1.000 24.53789 ? 62  PHE A CD1 1 
ATOM   501  C CD2 . PHE A 1 67  ? -7.22950  26.82892 -9.72269  1.000 25.69111 ? 62  PHE A CD2 1 
ATOM   502  C CE1 . PHE A 1 67  ? -7.12533  27.58778 -7.06673  1.000 24.16174 ? 62  PHE A CE1 1 
ATOM   503  C CE2 . PHE A 1 67  ? -6.56623  27.99475 -9.36065  1.000 28.65067 ? 62  PHE A CE2 1 
ATOM   504  C CZ  . PHE A 1 67  ? -6.52450  28.37755 -8.03136  1.000 24.50056 ? 62  PHE A CZ  1 
ATOM   505  N N   . ILE A 1 68  ? -11.02772 24.53515 -7.32567  1.000 19.18686 ? 63  ILE A N   1 
ATOM   506  C CA  . ILE A 1 68  ? -11.45723 24.80096 -5.96243  1.000 23.63952 ? 63  ILE A CA  1 
ATOM   507  C C   . ILE A 1 68  ? -10.38433 24.21570 -5.05926  1.000 23.22905 ? 63  ILE A C   1 
ATOM   508  O O   . ILE A 1 68  ? -9.97923  23.06491 -5.24706  1.000 26.50506 ? 63  ILE A O   1 
ATOM   509  C CB  . ILE A 1 68  ? -12.82895 24.17247 -5.66504  1.000 20.95226 ? 63  ILE A CB  1 
ATOM   510  C CG1 . ILE A 1 68  ? -13.87069 24.68502 -6.66791  1.000 18.76356 ? 63  ILE A CG1 1 
ATOM   511  C CG2 . ILE A 1 68  ? -13.25047 24.49025 -4.23870  1.000 22.94254 ? 63  ILE A CG2 1 
ATOM   512  C CD1 . ILE A 1 68  ? -15.19877 23.91174 -6.61872  1.000 19.57734 ? 63  ILE A CD1 1 
ATOM   513  N N   . ARG A 1 69  ? -9.88795  25.01176 -4.12227  1.000 21.59211 ? 64  ARG A N   1 
ATOM   514  C CA  . ARG A 1 69  ? -8.75040  24.58702 -3.32161  1.000 23.51744 ? 64  ARG A CA  1 
ATOM   515  C C   . ARG A 1 69  ? -9.05735  24.77628 -1.84733  1.000 21.60388 ? 64  ARG A C   1 
ATOM   516  O O   . ARG A 1 69  ? -9.50353  25.84623 -1.42798  1.000 24.25846 ? 64  ARG A O   1 
ATOM   517  C CB  . ARG A 1 69  ? -7.49333  25.36015 -3.71854  1.000 25.22794 ? 64  ARG A CB  1 
ATOM   518  C CG  . ARG A 1 69  ? -6.22626  24.87977 -3.00993  1.000 25.54316 ? 64  ARG A CG  1 
ATOM   519  C CD  . ARG A 1 69  ? -5.03260  25.66328 -3.54650  1.000 30.13136 ? 64  ARG A CD  1 
ATOM   520  N NE  . ARG A 1 69  ? -4.84874  25.40003 -4.96779  1.000 28.72313 ? 64  ARG A NE  1 
ATOM   521  C CZ  . ARG A 1 69  ? -4.23716  26.21429 -5.82013  1.000 31.94308 ? 64  ARG A CZ  1 
ATOM   522  N NH1 . ARG A 1 69  ? -3.76267  27.38975 -5.43655  1.000 33.88755 ? 64  ARG A NH1 1 
ATOM   523  N NH2 . ARG A 1 69  ? -4.11406  25.84617 -7.09391  1.000 34.73552 ? 64  ARG A NH2 1 
ATOM   524  N N   . ILE A 1 70  ? -8.80136  23.73524 -1.06525  1.000 22.14367 ? 65  ILE A N   1 
ATOM   525  C CA  . ILE A 1 70  ? -9.03776  23.74138 0.36980   1.000 21.28641 ? 65  ILE A CA  1 
ATOM   526  C C   . ILE A 1 70  ? -7.67624  23.69651 1.04412   1.000 23.10453 ? 65  ILE A C   1 
ATOM   527  O O   . ILE A 1 70  ? -6.90646  22.75290 0.81884   1.000 22.91735 ? 65  ILE A O   1 
ATOM   528  C CB  . ILE A 1 70  ? -9.89223  22.54424 0.80738   1.000 19.88800 ? 65  ILE A CB  1 
ATOM   529  C CG1 . ILE A 1 70  ? -11.20792 22.49651 0.02461   1.000 26.81514 ? 65  ILE A CG1 1 
ATOM   530  C CG2 . ILE A 1 70  ? -10.16647 22.60781 2.30391   1.000 21.32741 ? 65  ILE A CG2 1 
ATOM   531  C CD1 . ILE A 1 70  ? -11.98687 21.19771 0.24613   1.000 22.27818 ? 65  ILE A CD1 1 
ATOM   532  N N   . THR A 1 71  ? -7.37516  24.70367 1.86090   1.000 23.95492 ? 66  THR A N   1 
ATOM   533  C CA  . THR A 1 71  ? -6.08205  24.77171 2.54734   1.000 23.94879 ? 66  THR A CA  1 
ATOM   534  C C   . THR A 1 71  ? -6.27284  24.87900 4.05181   1.000 24.29568 ? 66  THR A C   1 
ATOM   535  O O   . THR A 1 71  ? -6.60606  25.96576 4.56425   1.000 22.41269 ? 66  THR A O   1 
ATOM   536  C CB  . THR A 1 71  ? -5.24442  25.94415 2.04568   1.000 23.77192 ? 66  THR A CB  1 
ATOM   537  O OG1 . THR A 1 71  ? -5.12008  25.88779 0.61897   1.000 25.14451 ? 66  THR A OG1 1 
ATOM   538  C CG2 . THR A 1 71  ? -3.83714  25.86716 2.66709   1.000 25.50542 ? 66  THR A CG2 1 
ATOM   539  N N   . PRO A 1 72  ? -6.07463  23.80001 4.80461   1.000 27.61322 ? 67  PRO A N   1 
ATOM   540  C CA  . PRO A 1 72  ? -6.05444  23.92762 6.26443   1.000 27.38670 ? 67  PRO A CA  1 
ATOM   541  C C   . PRO A 1 72  ? -4.79326  24.65363 6.69652   1.000 30.91685 ? 67  PRO A C   1 
ATOM   542  O O   . PRO A 1 72  ? -3.70588  24.40874 6.17031   1.000 29.22077 ? 67  PRO A O   1 
ATOM   543  C CB  . PRO A 1 72  ? -6.05381  22.47736 6.76442   1.000 31.78916 ? 67  PRO A CB  1 
ATOM   544  C CG  . PRO A 1 72  ? -6.18728  21.61166 5.55792   1.000 30.11272 ? 67  PRO A CG  1 
ATOM   545  C CD  . PRO A 1 72  ? -5.84029  22.41755 4.35629   1.000 28.09006 ? 67  PRO A CD  1 
ATOM   546  N N   . ARG A 1 73  ? -4.93812  25.54670 7.66638   1.000 26.00806 ? 68  ARG A N   1 
ATOM   547  C CA  . ARG A 1 73  ? -3.80805  26.27641 8.23714   1.000 26.12293 ? 68  ARG A CA  1 
ATOM   548  C C   . ARG A 1 73  ? -3.91567  26.07472 9.73954   1.000 31.22615 ? 68  ARG A C   1 
ATOM   549  O O   . ARG A 1 73  ? -4.35883  26.96837 10.47810  1.000 29.41735 ? 68  ARG A O   1 
ATOM   550  C CB  . ARG A 1 73  ? -3.82125  27.73940 7.79831   1.000 30.15781 ? 68  ARG A CB  1 
ATOM   551  C CG  . ARG A 1 73  ? -3.91641  27.89258 6.27061   1.000 27.70121 ? 68  ARG A CG  1 
ATOM   552  C CD  . ARG A 1 73  ? -3.93809  29.34877 5.80716   1.000 30.56072 ? 68  ARG A CD  1 
ATOM   553  N NE  . ARG A 1 73  ? -2.67143  30.02238 6.07236   1.000 34.76007 ? 68  ARG A NE  1 
ATOM   554  C CZ  . ARG A 1 73  ? -2.29126  31.16687 5.51350   1.000 45.07003 ? 68  ARG A CZ  1 
ATOM   555  N NH1 . ARG A 1 73  ? -3.05999  31.80391 4.64152   1.000 40.44074 ? 68  ARG A NH1 1 
ATOM   556  N NH2 . ARG A 1 73  ? -1.10082  31.67942 5.82530   1.000 41.48518 ? 68  ARG A NH2 1 
ATOM   557  N N   . PRO A 1 74  ? -3.54315  24.89299 10.23488  1.000 32.05634 ? 69  PRO A N   1 
ATOM   558  C CA  . PRO A 1 74  ? -3.82506  24.54122 11.63458  1.000 36.22006 ? 69  PRO A CA  1 
ATOM   559  C C   . PRO A 1 74  ? -3.16070  25.42949 12.67826  1.000 35.57387 ? 69  PRO A C   1 
ATOM   560  O O   . PRO A 1 74  ? -3.74948  25.61088 13.75333  1.000 38.39662 ? 69  PRO A O   1 
ATOM   561  C CB  . PRO A 1 74  ? -3.33918  23.09028 11.73569  1.000 37.00644 ? 69  PRO A CB  1 
ATOM   562  C CG  . PRO A 1 74  ? -2.45212  22.88563 10.57361  1.000 37.42998 ? 69  PRO A CG  1 
ATOM   563  C CD  . PRO A 1 74  ? -2.96359  23.76338 9.48870   1.000 33.34737 ? 69  PRO A CD  1 
ATOM   564  N N   . GLU A 1 75  ? -1.96831  25.98747 12.42524  1.000 34.54697 ? 70  GLU A N   1 
ATOM   565  C CA  . GLU A 1 75  ? -1.38189  26.88173 13.42679  1.000 37.78258 ? 70  GLU A CA  1 
ATOM   566  C C   . GLU A 1 75  ? -2.27257  28.09106 13.67247  1.000 38.64261 ? 70  GLU A C   1 
ATOM   567  O O   . GLU A 1 75  ? -2.43142  28.53333 14.81519  1.000 38.55534 ? 70  GLU A O   1 
ATOM   568  C CB  . GLU A 1 75  ? 0.01447   27.36132 13.02442  1.000 41.09636 ? 70  GLU A CB  1 
ATOM   569  C CG  . GLU A 1 75  ? 0.31319   28.71687 13.70209  1.000 46.86543 ? 70  GLU A CG  1 
ATOM   570  C CD  . GLU A 1 75  ? 1.77836   29.05821 13.86688  1.000 47.53493 ? 70  GLU A CD  1 
ATOM   571  O OE1 . GLU A 1 75  ? 2.46199   29.25899 12.84222  1.000 45.51138 ? 70  GLU A OE1 1 
ATOM   572  O OE2 . GLU A 1 75  ? 2.24862   29.13122 15.02626  1.000 45.38937 ? 70  GLU A OE2 1 
ATOM   573  N N   . GLU A 1 76  ? -2.85657  28.64682 12.61226  1.000 35.89399 ? 71  GLU A N   1 
ATOM   574  C CA  . GLU A 1 76  ? -3.74795  29.78856 12.75924  1.000 33.28233 ? 71  GLU A CA  1 
ATOM   575  C C   . GLU A 1 76  ? -5.17949  29.38048 13.09152  1.000 29.58597 ? 71  GLU A C   1 
ATOM   576  O O   . GLU A 1 76  ? -6.01847  30.26818 13.27657  1.000 34.16221 ? 71  GLU A O   1 
ATOM   577  C CB  . GLU A 1 76  ? -3.74145  30.63997 11.48135  1.000 35.28849 ? 71  GLU A CB  1 
ATOM   578  C CG  . GLU A 1 76  ? -2.44798  31.41755 11.23422  1.000 40.80224 ? 71  GLU A CG  1 
ATOM   579  C CD  . GLU A 1 76  ? -1.33035  30.54990 10.68138  1.000 46.61656 ? 71  GLU A CD  1 
ATOM   580  O OE1 . GLU A 1 76  ? -1.61574  29.44100 10.17042  1.000 43.27294 ? 71  GLU A OE1 1 
ATOM   581  O OE2 . GLU A 1 76  ? -0.15332  30.97825 10.75710  1.000 53.86874 ? 71  GLU A OE2 1 
ATOM   582  N N   . LYS A 1 77  ? -5.46129  28.07842 13.18572  1.000 27.13121 ? 72  LYS A N   1 
ATOM   583  C CA  . LYS A 1 77  ? -6.81894  27.54537 13.31423  1.000 30.08845 ? 72  LYS A CA  1 
ATOM   584  C C   . LYS A 1 77  ? -7.73200  28.12764 12.23292  1.000 29.88878 ? 72  LYS A C   1 
ATOM   585  O O   . LYS A 1 77  ? -8.83769  28.60683 12.49694  1.000 29.55100 ? 72  LYS A O   1 
ATOM   586  C CB  . LYS A 1 77  ? -7.38485  27.79520 14.71339  1.000 31.59943 ? 72  LYS A CB  1 
ATOM   587  C CG  . LYS A 1 77  ? -6.65167  27.03360 15.80198  1.000 31.46569 ? 72  LYS A CG  1 
ATOM   588  C CD  . LYS A 1 77  ? -7.03954  27.53422 17.18902  1.000 33.85775 ? 72  LYS A CD  1 
ATOM   589  C CE  . LYS A 1 77  ? -6.05806  27.01871 18.23322  1.000 46.35223 ? 72  LYS A CE  1 
ATOM   590  N NZ  . LYS A 1 77  ? -6.67052  26.89334 19.58713  1.000 46.98451 ? 72  LYS A NZ  1 
ATOM   591  N N   . VAL A 1 78  ? -7.24593  28.08013 10.99714  1.000 27.30766 ? 73  VAL A N   1 
ATOM   592  C CA  . VAL A 1 78  ? -7.91882  28.67088 9.84664   1.000 25.61816 ? 73  VAL A CA  1 
ATOM   593  C C   . VAL A 1 78  ? -8.10286  27.60496 8.77382   1.000 24.39953 ? 73  VAL A C   1 
ATOM   594  O O   . VAL A 1 78  ? -7.22822  26.75382 8.57310   1.000 25.87739 ? 73  VAL A O   1 
ATOM   595  C CB  . VAL A 1 78  ? -7.12911  29.87660 9.29795   1.000 30.44511 ? 73  VAL A CB  1 
ATOM   596  C CG1 . VAL A 1 78  ? -7.36766  30.05963 7.79801   1.000 26.75114 ? 73  VAL A CG1 1 
ATOM   597  C CG2 . VAL A 1 78  ? -7.50594  31.13602 10.05443  1.000 29.99252 ? 73  VAL A CG2 1 
ATOM   598  N N   . LEU A 1 79  ? -9.26258  27.62590 8.11061   1.000 23.16317 ? 74  LEU A N   1 
ATOM   599  C CA  . LEU A 1 79  ? -9.51892  26.82201 6.92051   1.000 23.68450 ? 74  LEU A CA  1 
ATOM   600  C C   . LEU A 1 79  ? -9.82321  27.76628 5.76346   1.000 26.28471 ? 74  LEU A C   1 
ATOM   601  O O   . LEU A 1 79  ? -10.68623 28.64305 5.88875   1.000 22.71675 ? 74  LEU A O   1 
ATOM   602  C CB  . LEU A 1 79  ? -10.68821 25.85596 7.14204   1.000 26.25401 ? 74  LEU A CB  1 
ATOM   603  C CG  . LEU A 1 79  ? -11.07859 24.89141 6.00953   1.000 26.32277 ? 74  LEU A CG  1 
ATOM   604  C CD1 . LEU A 1 79  ? -9.98401  23.89138 5.69985   1.000 26.52456 ? 74  LEU A CD1 1 
ATOM   605  C CD2 . LEU A 1 79  ? -12.37673 24.14689 6.35820   1.000 25.42653 ? 74  LEU A CD2 1 
ATOM   606  N N   . GLU A 1 80  ? -9.10906  27.60908 4.64775   1.000 23.26552 ? 75  GLU A N   1 
ATOM   607  C CA  . GLU A 1 80  ? -9.30555  28.47379 3.48697   1.000 23.18805 ? 75  GLU A CA  1 
ATOM   608  C C   . GLU A 1 80  ? -9.96578  27.68591 2.37170   1.000 22.01977 ? 75  GLU A C   1 
ATOM   609  O O   . GLU A 1 80  ? -9.53741  26.56926 2.04991   1.000 24.65991 ? 75  GLU A O   1 
ATOM   610  C CB  . GLU A 1 80  ? -7.98210  29.09027 2.99921   1.000 22.14364 ? 75  GLU A CB  1 
ATOM   611  C CG  . GLU A 1 80  ? -7.43144  30.11448 4.00082   1.000 26.05895 ? 75  GLU A CG  1 
ATOM   612  C CD  . GLU A 1 80  ? -6.21743  30.90009 3.50099   1.000 28.16244 ? 75  GLU A CD  1 
ATOM   613  O OE1 . GLU A 1 80  ? -5.73772  30.64020 2.37822   1.000 26.01026 ? 75  GLU A OE1 1 
ATOM   614  O OE2 . GLU A 1 80  ? -5.74910  31.77783 4.26059   1.000 27.13162 ? 75  GLU A OE2 1 
ATOM   615  N N   . ILE A 1 81  ? -11.01740 28.25766 1.79447   1.000 21.92581 ? 76  ILE A N   1 
ATOM   616  C CA  . ILE A 1 81  ? -11.67980 27.66513 0.63774   1.000 21.99019 ? 76  ILE A CA  1 
ATOM   617  C C   . ILE A 1 81  ? -11.53687 28.66667 -0.49786  1.000 21.22948 ? 76  ILE A C   1 
ATOM   618  O O   . ILE A 1 81  ? -12.10335 29.76607 -0.44853  1.000 22.71902 ? 76  ILE A O   1 
ATOM   619  C CB  . ILE A 1 81  ? -13.14272 27.30511 0.92302   1.000 22.85271 ? 76  ILE A CB  1 
ATOM   620  C CG1 . ILE A 1 81  ? -13.15566 26.29253 2.07812   1.000 30.80509 ? 76  ILE A CG1 1 
ATOM   621  C CG2 . ILE A 1 81  ? -13.79609 26.66498 -0.31226  1.000 22.79996 ? 76  ILE A CG2 1 
ATOM   622  C CD1 . ILE A 1 81  ? -14.48647 25.94933 2.61935   1.000 34.77432 ? 76  ILE A CD1 1 
ATOM   623  N N   . ARG A 1 82  ? -10.76635 28.29204 -1.50975  1.000 19.25542 ? 77  ARG A N   1 
ATOM   624  C CA  . ARG A 1 82  ? -10.38508 29.18841 -2.59641  1.000 23.18871 ? 77  ARG A CA  1 
ATOM   625  C C   . ARG A 1 82  ? -11.01624 28.72609 -3.90033  1.000 21.83423 ? 77  ARG A C   1 
ATOM   626  O O   . ARG A 1 82  ? -11.04115 27.53053 -4.19587  1.000 22.32052 ? 77  ARG A O   1 
ATOM   627  C CB  . ARG A 1 82  ? -8.85573  29.22763 -2.76299  1.000 22.20322 ? 77  ARG A CB  1 
ATOM   628  C CG  . ARG A 1 82  ? -8.37275  29.74975 -4.12658  1.000 24.46177 ? 77  ARG A CG  1 
ATOM   629  C CD  . ARG A 1 82  ? -8.50808  31.24171 -4.23863  1.000 24.93610 ? 77  ARG A CD  1 
ATOM   630  N NE  . ARG A 1 82  ? -8.36113  31.71945 -5.61452  1.000 29.66575 ? 77  ARG A NE  1 
ATOM   631  C CZ  . ARG A 1 82  ? -7.19686  31.84088 -6.23724  1.000 31.86460 ? 77  ARG A CZ  1 
ATOM   632  N NH1 . ARG A 1 82  ? -6.05464  31.50037 -5.64514  1.000 30.48750 ? 77  ARG A NH1 1 
ATOM   633  N NH2 . ARG A 1 82  ? -7.17288  32.32027 -7.47880  1.000 28.45666 ? 77  ARG A NH2 1 
ATOM   634  N N   . ASP A 1 83  ? -11.50560 29.67290 -4.69356  1.000 21.10837 ? 78  ASP A N   1 
ATOM   635  C CA  . ASP A 1 83  ? -11.88733 29.35766 -6.05468  1.000 22.04232 ? 78  ASP A CA  1 
ATOM   636  C C   . ASP A 1 83  ? -11.24423 30.36933 -6.98767  1.000 20.07261 ? 78  ASP A C   1 
ATOM   637  O O   . ASP A 1 83  ? -10.95209 31.50107 -6.59278  1.000 20.79349 ? 78  ASP A O   1 
ATOM   638  C CB  . ASP A 1 83  ? -13.42140 29.34347 -6.23963  1.000 21.58359 ? 78  ASP A CB  1 
ATOM   639  C CG  . ASP A 1 83  ? -14.06070 30.68781 -5.98675  1.000 23.04333 ? 78  ASP A CG  1 
ATOM   640  O OD1 . ASP A 1 83  ? -13.94006 31.59173 -6.84486  1.000 22.73719 ? 78  ASP A OD1 1 
ATOM   641  O OD2 . ASP A 1 83  ? -14.71012 30.84899 -4.92924  1.000 25.72759 ? 78  ASP A OD2 1 
ATOM   642  N N   . SER A 1 84  ? -11.02416 29.94455 -8.22702  1.000 19.58078 ? 79  SER A N   1 
ATOM   643  C CA  . SER A 1 84  ? -10.60630 30.84573 -9.30041  1.000 20.50535 ? 79  SER A CA  1 
ATOM   644  C C   . SER A 1 84  ? -11.79664 31.26827 -10.15280 1.000 22.90836 ? 79  SER A C   1 
ATOM   645  O O   . SER A 1 84  ? -11.72145 31.30791 -11.38608 1.000 21.73002 ? 79  SER A O   1 
ATOM   646  C CB  . SER A 1 84  ? -9.52372  30.19520 -10.15277 1.000 24.28781 ? 79  SER A CB  1 
ATOM   647  O OG  . SER A 1 84  ? -9.92718  28.91942 -10.61997 1.000 25.63945 ? 79  SER A OG  1 
ATOM   648  N N   . GLY A 1 85  ? -12.92912 31.54041 -9.50934  1.000 21.22274 ? 80  GLY A N   1 
ATOM   649  C CA  . GLY A 1 85  ? -14.11425 32.01064 -10.19895 1.000 20.70583 ? 80  GLY A CA  1 
ATOM   650  C C   . GLY A 1 85  ? -14.06646 33.49845 -10.48448 1.000 22.88540 ? 80  GLY A C   1 
ATOM   651  O O   . GLY A 1 85  ? -13.00421 34.13322 -10.52619 1.000 20.67182 ? 80  GLY A O   1 
ATOM   652  N N   . ILE A 1 86  ? -15.25659 34.06478 -10.65890 1.000 20.86117 ? 81  ILE A N   1 
ATOM   653  C CA  . ILE A 1 86  ? -15.36051 35.40632 -11.21846 1.000 22.34478 ? 81  ILE A CA  1 
ATOM   654  C C   . ILE A 1 86  ? -14.85448 36.46515 -10.23547 1.000 26.47286 ? 81  ILE A C   1 
ATOM   655  O O   . ILE A 1 86  ? -14.41031 37.54234 -10.65191 1.000 22.67670 ? 81  ILE A O   1 
ATOM   656  C CB  . ILE A 1 86  ? -16.81440 35.66590 -11.65702 1.000 21.55294 ? 81  ILE A CB  1 
ATOM   657  C CG1 . ILE A 1 86  ? -16.91184 36.99171 -12.41940 1.000 24.76134 ? 81  ILE A CG1 1 
ATOM   658  C CG2 . ILE A 1 86  ? -17.75997 35.62804 -10.46242 1.000 25.38423 ? 81  ILE A CG2 1 
ATOM   659  C CD1 . ILE A 1 86  ? -18.18625 37.11786 -13.24977 1.000 26.98912 ? 81  ILE A CD1 1 
ATOM   660  N N   . GLY A 1 87  ? -14.91566 36.19037 -8.93648  1.000 22.62811 ? 82  GLY A N   1 
ATOM   661  C CA  . GLY A 1 87  ? -14.51954 37.15939 -7.93069  1.000 21.54139 ? 82  GLY A CA  1 
ATOM   662  C C   . GLY A 1 87  ? -15.55846 38.24996 -7.74573  1.000 25.11448 ? 82  GLY A C   1 
ATOM   663  O O   . GLY A 1 87  ? -16.49793 38.40772 -8.53039  1.000 25.64126 ? 82  GLY A O   1 
ATOM   664  N N   . MET A 1 88  ? -15.38543 39.02716 -6.67414  1.000 20.48335 ? 83  MET A N   1 
ATOM   665  C CA  . MET A 1 88  ? -16.31418 40.09693 -6.33952  1.000 21.74910 ? 83  MET A CA  1 
ATOM   666  C C   . MET A 1 88  ? -15.58904 41.42619 -6.21636  1.000 26.03193 ? 83  MET A C   1 
ATOM   667  O O   . MET A 1 88  ? -14.50172 41.49454 -5.64050  1.000 23.37027 ? 83  MET A O   1 
ATOM   668  C CB  . MET A 1 88  ? -17.05983 39.80853 -5.03900  1.000 26.20493 ? 83  MET A CB  1 
ATOM   669  C CG  . MET A 1 88  ? -18.12182 38.70205 -5.17934  1.000 29.14197 ? 83  MET A CG  1 
ATOM   670  S SD  . MET A 1 88  ? -18.95578 38.37082 -3.62394  1.000 28.93691 ? 83  MET A SD  1 
ATOM   671  C CE  . MET A 1 88  ? -17.75696 37.28136 -2.87102  1.000 32.13765 ? 83  MET A CE  1 
ATOM   672  N N   . THR A 1 89  ? -16.19241 42.47771 -6.77360  1.000 26.43669 ? 84  THR A N   1 
ATOM   673  C CA  . THR A 1 89  ? -15.68454 43.82853 -6.57609  1.000 26.92005 ? 84  THR A CA  1 
ATOM   674  C C   . THR A 1 89  ? -16.00243 44.30172 -5.16238  1.000 25.87212 ? 84  THR A C   1 
ATOM   675  O O   . THR A 1 89  ? -16.75422 43.66477 -4.41620  1.000 24.73824 ? 84  THR A O   1 
ATOM   676  C CB  . THR A 1 89  ? -16.30028 44.80506 -7.58351  1.000 25.84838 ? 84  THR A CB  1 
ATOM   677  O OG1 . THR A 1 89  ? -17.71181 44.91444 -7.34011  1.000 24.77973 ? 84  THR A OG1 1 
ATOM   678  C CG2 . THR A 1 89  ? -16.04768 44.34985 -9.02101  1.000 25.55127 ? 84  THR A CG2 1 
ATOM   679  N N   . LYS A 1 90  ? -15.43441 45.45731 -4.80173  1.000 26.40971 ? 85  LYS A N   1 
ATOM   680  C CA  . LYS A 1 90  ? -15.75960 46.05703 -3.51153  1.000 24.46771 ? 85  LYS A CA  1 
ATOM   681  C C   . LYS A 1 90  ? -17.26173 46.28653 -3.38720  1.000 28.26820 ? 85  LYS A C   1 
ATOM   682  O O   . LYS A 1 90  ? -17.87234 45.97433 -2.35348  1.000 25.49544 ? 85  LYS A O   1 
ATOM   683  C CB  . LYS A 1 90  ? -14.99009 47.37343 -3.33667  1.000 28.79345 ? 85  LYS A CB  1 
ATOM   684  C CG  . LYS A 1 90  ? -15.24523 48.06184 -1.99786  1.000 27.80591 ? 85  LYS A CG  1 
ATOM   685  C CD  . LYS A 1 90  ? -14.74450 49.50868 -2.00442  1.000 31.60964 ? 85  LYS A CD  1 
ATOM   686  C CE  . LYS A 1 90  ? -15.01655 50.17738 -0.65753  1.000 36.26116 ? 85  LYS A CE  1 
ATOM   687  N NZ  . LYS A 1 90  ? -14.58778 51.60625 -0.65582  1.000 36.80194 ? 85  LYS A NZ  1 
ATOM   688  N N   . ALA A 1 91  ? -17.87848 46.83333 -4.43934  1.000 25.94663 ? 86  ALA A N   1 
ATOM   689  C CA  . ALA A 1 91  ? -19.30968 47.10850 -4.39696  1.000 28.84726 ? 86  ALA A CA  1 
ATOM   690  C C   . ALA A 1 91  ? -20.11165 45.81800 -4.25180  1.000 26.77914 ? 86  ALA A C   1 
ATOM   691  O O   . ALA A 1 91  ? -21.10380 45.77176 -3.51848  1.000 28.31832 ? 86  ALA A O   1 
ATOM   692  C CB  . ALA A 1 91  ? -19.73170 47.87026 -5.65217  1.000 28.36833 ? 86  ALA A CB  1 
ATOM   693  N N   . GLU A 1 92  ? -19.68774 44.75935 -4.94404  1.000 27.59372 ? 87  GLU A N   1 
ATOM   694  C CA  . GLU A 1 92  ? -20.38325 43.47746 -4.85849  1.000 29.19074 ? 87  GLU A CA  1 
ATOM   695  C C   . GLU A 1 92  ? -20.23300 42.83962 -3.47742  1.000 28.95480 ? 87  GLU A C   1 
ATOM   696  O O   . GLU A 1 92  ? -21.19091 42.26812 -2.94482  1.000 28.78116 ? 87  GLU A O   1 
ATOM   697  C CB  . GLU A 1 92  ? -19.87162 42.54922 -5.96563  1.000 27.38237 ? 87  GLU A CB  1 
ATOM   698  C CG  . GLU A 1 92  ? -20.37431 42.95817 -7.35241  1.000 31.72355 ? 87  GLU A CG  1 
ATOM   699  C CD  . GLU A 1 92  ? -19.62958 42.29584 -8.51569  1.000 37.94065 ? 87  GLU A CD  1 
ATOM   700  O OE1 . GLU A 1 92  ? -18.51406 41.78097 -8.31899  1.000 33.81040 ? 87  GLU A OE1 1 
ATOM   701  O OE2 . GLU A 1 92  ? -20.16534 42.30620 -9.64685  1.000 42.16056 ? 87  GLU A OE2 1 
ATOM   702  N N   . LEU A 1 93  ? -19.04362 42.91820 -2.87860  1.000 26.32818 ? 88  LEU A N   1 
ATOM   703  C CA  . LEU A 1 93  ? -18.87309 42.38193 -1.52901  1.000 27.40985 ? 88  LEU A CA  1 
ATOM   704  C C   . LEU A 1 93  ? -19.84858 43.03218 -0.56117  1.000 27.84702 ? 88  LEU A C   1 
ATOM   705  O O   . LEU A 1 93  ? -20.50884 42.35020 0.23137   1.000 25.62793 ? 88  LEU A O   1 
ATOM   706  C CB  . LEU A 1 93  ? -17.43827 42.60382 -1.04715  1.000 24.31342 ? 88  LEU A CB  1 
ATOM   707  C CG  . LEU A 1 93  ? -16.32696 41.76951 -1.66244  1.000 22.84886 ? 88  LEU A CG  1 
ATOM   708  C CD1 . LEU A 1 93  ? -14.97366 42.35854 -1.26487  1.000 23.08767 ? 88  LEU A CD1 1 
ATOM   709  C CD2 . LEU A 1 93  ? -16.44726 40.34325 -1.17665  1.000 23.86377 ? 88  LEU A CD2 1 
ATOM   710  N N   . ILE A 1 94  ? -19.93888 44.36407 -0.61327  1.000 30.08442 ? 89  ILE A N   1 
ATOM   711  C CA  . ILE A 1 94  ? -20.84147 45.10423 0.26228   1.000 30.54384 ? 89  ILE A CA  1 
ATOM   712  C C   . ILE A 1 94  ? -22.28188 44.70045 -0.00684  1.000 32.05685 ? 89  ILE A C   1 
ATOM   713  O O   . ILE A 1 94  ? -23.04965 44.40771 0.91762   1.000 33.10554 ? 89  ILE A O   1 
ATOM   714  C CB  . ILE A 1 94  ? -20.65391 46.61877 0.05408   1.000 31.97868 ? 89  ILE A CB  1 
ATOM   715  C CG1 . ILE A 1 94  ? -19.24084 47.07142 0.43755   1.000 29.50759 ? 89  ILE A CG1 1 
ATOM   716  C CG2 . ILE A 1 94  ? -21.70704 47.40362 0.83443   1.000 34.88764 ? 89  ILE A CG2 1 
ATOM   717  C CD1 . ILE A 1 94  ? -18.87576 48.43365 -0.16015  1.000 30.37804 ? 89  ILE A CD1 1 
ATOM   718  N N   . ASN A 1 95  ? -22.66225 44.68452 -1.28768  1.000 31.99882 ? 90  ASN A N   1 
ATOM   719  C CA  . ASN A 1 95  ? -24.04326 44.44157 -1.69927  1.000 33.01002 ? 90  ASN A CA  1 
ATOM   720  C C   . ASN A 1 95  ? -24.43096 42.97588 -1.50329  1.000 34.55406 ? 90  ASN A C   1 
ATOM   721  O O   . ASN A 1 95  ? -25.40535 42.65898 -0.81170  1.000 37.89975 ? 90  ASN A O   1 
ATOM   722  C CB  . ASN A 1 95  ? -24.19432 44.83973 -3.17201  1.000 37.19846 ? 90  ASN A CB  1 
ATOM   723  C CG  . ASN A 1 95  ? -25.63019 44.82048 -3.65428  1.000 45.92631 ? 90  ASN A CG  1 
ATOM   724  O OD1 . ASN A 1 95  ? -26.47474 45.51670 -3.10983  1.000 46.13854 ? 90  ASN A OD1 1 
ATOM   725  N ND2 . ASN A 1 95  ? -25.89855 44.06264 -4.72060  1.000 49.12346 ? 90  ASN A ND2 1 
ATOM   726  N N   . ASN A 1 96  ? -23.67214 42.07130 -2.11742  1.000 31.07145 ? 91  ASN A N   1 
ATOM   727  C CA  . ASN A 1 96  ? -24.04730 40.65839 -2.11745  1.000 31.53645 ? 91  ASN A CA  1 
ATOM   728  C C   . ASN A 1 96  ? -23.98622 40.04052 -0.72883  1.000 35.54520 ? 91  ASN A C   1 
ATOM   729  O O   . ASN A 1 96  ? -24.75722 39.12374 -0.43064  1.000 37.82901 ? 91  ASN A O   1 
ATOM   730  C CB  . ASN A 1 96  ? -23.14262 39.87568 -3.06540  1.000 32.10913 ? 91  ASN A CB  1 
ATOM   731  C CG  . ASN A 1 96  ? -23.29850 40.30866 -4.50701  1.000 38.63545 ? 91  ASN A CG  1 
ATOM   732  O OD1 . ASN A 1 96  ? -24.00177 41.27425 -4.80271  1.000 41.92712 ? 91  ASN A OD1 1 
ATOM   733  N ND2 . ASN A 1 96  ? -22.63915 39.59753 -5.41330  1.000 39.68916 ? 91  ASN A ND2 1 
ATOM   734  N N   . LEU A 1 97  ? -23.05882 40.47531 0.11893   1.000 30.05715 ? 92  LEU A N   1 
ATOM   735  C CA  . LEU A 1 97  ? -22.86145 39.77225 1.37924   1.000 30.12600 ? 92  LEU A CA  1 
ATOM   736  C C   . LEU A 1 97  ? -23.50445 40.46035 2.56917   1.000 35.15076 ? 92  LEU A C   1 
ATOM   737  O O   . LEU A 1 97  ? -23.85108 39.77780 3.53852   1.000 31.11465 ? 92  LEU A O   1 
ATOM   738  C CB  . LEU A 1 97  ? -21.36376 39.57920 1.66377   1.000 28.00759 ? 92  LEU A CB  1 
ATOM   739  C CG  . LEU A 1 97  ? -20.58599 38.71953 0.66053   1.000 31.00091 ? 92  LEU A CG  1 
ATOM   740  C CD1 . LEU A 1 97  ? -19.09717 38.60511 1.04161   1.000 26.78620 ? 92  LEU A CD1 1 
ATOM   741  C CD2 . LEU A 1 97  ? -21.20828 37.32748 0.51766   1.000 28.85099 ? 92  LEU A CD2 1 
ATOM   742  N N   . GLY A 1 98  ? -23.60788 41.78928 2.57861   1.000 33.97105 ? 93  GLY A N   1 
ATOM   743  C CA  . GLY A 1 98  ? -24.09195 42.37080 3.81326   1.000 34.20990 ? 93  GLY A CA  1 
ATOM   744  C C   . GLY A 1 98  ? -25.30591 43.27260 3.81121   1.000 40.40108 ? 93  GLY A C   1 
ATOM   745  O O   . GLY A 1 98  ? -26.13741 43.19861 4.72225   1.000 39.74330 ? 93  GLY A O   1 
ATOM   746  N N   . THR A 1 99  ? -25.44635 44.11597 2.80013   1.000 44.41491 ? 94  THR A N   1 
ATOM   747  C CA  . THR A 1 99  ? -26.36378 45.23299 2.93952   1.000 43.02709 ? 94  THR A CA  1 
ATOM   748  C C   . THR A 1 99  ? -27.65329 45.07305 2.14952   1.000 48.81736 ? 94  THR A C   1 
ATOM   749  O O   . THR A 1 99  ? -28.57232 45.87686 2.35616   1.000 46.53542 ? 94  THR A O   1 
ATOM   750  C CB  . THR A 1 99  ? -25.68590 46.56096 2.55486   1.000 44.21210 ? 94  THR A CB  1 
ATOM   751  O OG1 . THR A 1 99  ? -25.21100 46.49404 1.20648   1.000 48.46056 ? 94  THR A OG1 1 
ATOM   752  C CG2 . THR A 1 99  ? -24.52465 46.89274 3.51624   1.000 39.25545 ? 94  THR A CG2 1 
ATOM   753  N N   . ILE A 1 100 ? -27.76373 44.09480 1.24155   1.000 43.78404 ? 95  ILE A N   1 
ATOM   754  C CA  . ILE A 1 100 ? -29.12636 43.69298 0.91077   1.000 53.59745 ? 95  ILE A CA  1 
ATOM   755  C C   . ILE A 1 100 ? -29.33751 42.18168 1.03719   1.000 48.23826 ? 95  ILE A C   1 
ATOM   756  O O   . ILE A 1 100 ? -29.80599 41.72533 2.07966   1.000 55.65943 ? 95  ILE A O   1 
ATOM   757  C CB  . ILE A 1 100 ? -29.51332 44.22618 -0.48711  1.000 55.93259 ? 95  ILE A CB  1 
ATOM   758  C CG1 . ILE A 1 100 ? -30.87507 43.67521 -0.94250  1.000 59.79395 ? 95  ILE A CG1 1 
ATOM   759  C CG2 . ILE A 1 100 ? -28.41536 43.97204 -1.49520  1.000 52.61195 ? 95  ILE A CG2 1 
ATOM   760  C CD1 . ILE A 1 100 ? -32.05533 44.18868 -0.12176  1.000 61.94307 ? 95  ILE A CD1 1 
ATOM   761  N N   . ALA A 1 101 ? -28.94009 41.39157 0.03066   1.000 54.71105 ? 96  ALA A N   1 
ATOM   762  C CA  . ALA A 1 101 ? -28.94207 39.92005 0.05366   1.000 57.22143 ? 96  ALA A CA  1 
ATOM   763  C C   . ALA A 1 101 ? -30.00237 39.21593 0.91133   1.000 56.09638 ? 96  ALA A C   1 
ATOM   764  O O   . ALA A 1 101 ? -29.71250 38.13934 1.44462   1.000 59.04811 ? 96  ALA A O   1 
ATOM   765  C CB  . ALA A 1 101 ? -27.57423 39.42218 0.52023   1.000 55.21790 ? 96  ALA A CB  1 
ATOM   766  N N   . LYS A 1 102 ? -31.22833 39.73772 1.03461   1.000 54.31788 ? 97  LYS A N   1 
ATOM   767  C CA  . LYS A 1 102 ? -32.05282 39.36572 2.19002   1.000 56.40481 ? 97  LYS A CA  1 
ATOM   768  C C   . LYS A 1 102 ? -33.40635 38.72799 1.86441   1.000 51.44120 ? 97  LYS A C   1 
ATOM   769  O O   . LYS A 1 102 ? -34.23215 38.57928 2.77416   1.000 51.69085 ? 97  LYS A O   1 
ATOM   770  C CB  . LYS A 1 102 ? -32.27341 40.58137 3.10105   1.000 52.53123 ? 97  LYS A CB  1 
ATOM   771  C CG  . LYS A 1 102 ? -32.92635 41.78172 2.42137   1.000 60.76204 ? 97  LYS A CG  1 
ATOM   772  C CD  . LYS A 1 102 ? -34.42725 41.82366 2.68863   1.000 64.74122 ? 97  LYS A CD  1 
ATOM   773  C CE  . LYS A 1 102 ? -35.20911 42.20511 1.43997   1.000 64.66765 ? 97  LYS A CE  1 
ATOM   774  N NZ  . LYS A 1 102 ? -36.44980 41.39436 1.33139   1.000 63.41413 ? 97  LYS A NZ  1 
ATOM   775  N N   . SER A 1 103 ? -33.65480 38.31735 0.61935   1.000 58.43798 ? 98  SER A N   1 
ATOM   776  C CA  . SER A 1 103 ? -34.96577 37.76664 0.27270   1.000 54.76287 ? 98  SER A CA  1 
ATOM   777  C C   . SER A 1 103 ? -35.09458 36.30787 0.70518   1.000 50.49049 ? 98  SER A C   1 
ATOM   778  O O   . SER A 1 103 ? -35.94163 35.96837 1.54220   1.000 47.13523 ? 98  SER A O   1 
ATOM   779  C CB  . SER A 1 103 ? -35.21327 37.90152 -1.23098  1.000 58.03944 ? 98  SER A CB  1 
ATOM   780  O OG  . SER A 1 103 ? -35.18033 39.25881 -1.64539  1.000 62.63021 ? 98  SER A OG  1 
ATOM   781  N N   . GLY A 1 104 ? -34.25685 35.42641 0.15062   1.000 49.79996 ? 99  GLY A N   1 
ATOM   782  C CA  . GLY A 1 104 ? -34.24342 34.05667 0.63772   1.000 39.00169 ? 99  GLY A CA  1 
ATOM   783  C C   . GLY A 1 104 ? -33.91791 33.96725 2.11489   1.000 36.41160 ? 99  GLY A C   1 
ATOM   784  O O   . GLY A 1 104 ? -34.26046 32.97453 2.77000   1.000 30.81250 ? 99  GLY A O   1 
ATOM   785  N N   . THR A 1 105 ? -33.28971 35.00761 2.65914   1.000 34.53712 ? 100 THR A N   1 
ATOM   786  C CA  . THR A 1 105 ? -32.86512 35.00867 4.05215   1.000 29.96750 ? 100 THR A CA  1 
ATOM   787  C C   . THR A 1 105 ? -34.04646 34.85120 5.01279   1.000 33.10410 ? 100 THR A C   1 
ATOM   788  O O   . THR A 1 105 ? -34.03208 33.99395 5.90745   1.000 28.77860 ? 100 THR A O   1 
ATOM   789  C CB  . THR A 1 105 ? -32.12044 36.31248 4.31999   1.000 41.22444 ? 100 THR A CB  1 
ATOM   790  O OG1 . THR A 1 105 ? -31.22083 36.56765 3.22235   1.000 41.09232 ? 100 THR A OG1 1 
ATOM   791  C CG2 . THR A 1 105 ? -31.36967 36.23105 5.61430   1.000 33.71456 ? 100 THR A CG2 1 
ATOM   792  N N   . LYS A 1 106 ? -35.07539 35.68163 4.86752   1.000 31.25127 ? 101 LYS A N   1 
ATOM   793  C CA  . LYS A 1 106 ? -36.17142 35.55373 5.82247   1.000 32.56864 ? 101 LYS A CA  1 
ATOM   794  C C   . LYS A 1 106 ? -37.04850 34.34098 5.51057   1.000 31.02904 ? 101 LYS A C   1 
ATOM   795  O O   . LYS A 1 106 ? -37.52586 33.67028 6.43323   1.000 31.91110 ? 101 LYS A O   1 
ATOM   796  C CB  . LYS A 1 106 ? -36.97495 36.85857 5.87265   1.000 43.41484 ? 101 LYS A CB  1 
ATOM   797  C CG  . LYS A 1 106 ? -37.96496 37.05934 4.76496   1.000 46.96888 ? 101 LYS A CG  1 
ATOM   798  C CD  . LYS A 1 106 ? -39.39008 37.01677 5.31225   1.000 55.33224 ? 101 LYS A CD  1 
ATOM   799  C CE  . LYS A 1 106 ? -40.42139 37.26910 4.21989   1.000 55.01479 ? 101 LYS A CE  1 
ATOM   800  N NZ  . LYS A 1 106 ? -41.80293 37.45166 4.76895   1.000 60.20176 ? 101 LYS A NZ  1 
ATOM   801  N N   . ALA A 1 107 ? -37.22135 33.99863 4.23029   1.000 30.94722 ? 102 ALA A N   1 
ATOM   802  C CA  . ALA A 1 107 ? -37.94436 32.77410 3.89774   1.000 28.22146 ? 102 ALA A CA  1 
ATOM   803  C C   . ALA A 1 107 ? -37.27058 31.54789 4.51752   1.000 25.53162 ? 102 ALA A C   1 
ATOM   804  O O   . ALA A 1 107 ? -37.94898 30.63036 4.99747   1.000 24.01609 ? 102 ALA A O   1 
ATOM   805  C CB  . ALA A 1 107 ? -38.05874 32.63440 2.37866   1.000 29.17580 ? 102 ALA A CB  1 
ATOM   806  N N   . PHE A 1 108 ? -35.93462 31.50899 4.52460   1.000 23.93231 ? 103 PHE A N   1 
ATOM   807  C CA  . PHE A 1 108 ? -35.24589 30.36547 5.14185   1.000 24.40051 ? 103 PHE A CA  1 
ATOM   808  C C   . PHE A 1 108 ? -35.43565 30.34255 6.65445   1.000 26.22961 ? 103 PHE A C   1 
ATOM   809  O O   . PHE A 1 108 ? -35.62764 29.27289 7.25525   1.000 23.73623 ? 103 PHE A O   1 
ATOM   810  C CB  . PHE A 1 108 ? -33.75124 30.39109 4.78851   1.000 22.32958 ? 103 PHE A CB  1 
ATOM   811  C CG  . PHE A 1 108 ? -32.94976 29.30782 5.45982   1.000 23.82671 ? 103 PHE A CG  1 
ATOM   812  C CD1 . PHE A 1 108 ? -33.27429 27.96993 5.27104   1.000 26.31898 ? 103 PHE A CD1 1 
ATOM   813  C CD2 . PHE A 1 108 ? -31.86901 29.62179 6.27094   1.000 25.69465 ? 103 PHE A CD2 1 
ATOM   814  C CE1 . PHE A 1 108 ? -32.53367 26.95685 5.89016   1.000 25.37280 ? 103 PHE A CE1 1 
ATOM   815  C CE2 . PHE A 1 108 ? -31.12899 28.62514 6.88190   1.000 25.74293 ? 103 PHE A CE2 1 
ATOM   816  C CZ  . PHE A 1 108 ? -31.46183 27.28952 6.68979   1.000 24.53256 ? 103 PHE A CZ  1 
ATOM   817  N N   . MET A 1 109 ? -35.36995 31.50552 7.30064   1.000 21.47199 ? 104 MET A N   1 
ATOM   818  C CA  . MET A 1 109 ? -35.61470 31.53222 8.73809   1.000 26.91475 ? 104 MET A CA  1 
ATOM   819  C C   . MET A 1 109 ? -37.03543 31.08080 9.06378   1.000 27.97145 ? 104 MET A C   1 
ATOM   820  O O   . MET A 1 109 ? -37.25513 30.37068 10.05127  1.000 31.27686 ? 104 MET A O   1 
ATOM   821  C CB  . MET A 1 109 ? -35.33718 32.92966 9.28329   1.000 26.67005 ? 104 MET A CB  1 
ATOM   822  C CG  . MET A 1 109 ? -33.85092 33.23331 9.29960   1.000 29.24587 ? 104 MET A CG  1 
ATOM   823  S SD  . MET A 1 109 ? -33.49491 34.75734 10.17565  1.000 35.22385 ? 104 MET A SD  1 
ATOM   824  C CE  . MET A 1 109 ? -34.17085 35.95420 9.03396   1.000 28.75605 ? 104 MET A CE  1 
ATOM   825  N N   . GLU A 1 110 ? -38.00921 31.46966 8.23890   1.000 26.09340 ? 105 GLU A N   1 
ATOM   826  C CA  . GLU A 1 110 ? -39.37288 30.99388 8.43852   1.000 29.38840 ? 105 GLU A CA  1 
ATOM   827  C C   . GLU A 1 110 ? -39.45673 29.48619 8.26717   1.000 30.12817 ? 105 GLU A C   1 
ATOM   828  O O   . GLU A 1 110 ? -40.17800 28.81146 9.01027   1.000 30.72777 ? 105 GLU A O   1 
ATOM   829  C CB  . GLU A 1 110 ? -40.33031 31.71196 7.48604   1.000 30.95010 ? 105 GLU A CB  1 
ATOM   830  C CG  . GLU A 1 110 ? -40.59076 33.14150 7.93248   1.000 40.05796 ? 105 GLU A CG  1 
ATOM   831  C CD  . GLU A 1 110 ? -41.32541 33.98094 6.90926   1.000 46.89916 ? 105 GLU A CD  1 
ATOM   832  O OE1 . GLU A 1 110 ? -41.82790 33.41323 5.91189   1.000 50.89680 ? 105 GLU A OE1 1 
ATOM   833  O OE2 . GLU A 1 110 ? -41.40184 35.21730 7.10787   1.000 50.84365 ? 105 GLU A OE2 1 
ATOM   834  N N   . ALA A 1 111 ? -38.72365 28.93632 7.29352   1.000 25.66607 ? 106 ALA A N   1 
ATOM   835  C CA  . ALA A 1 111 ? -38.69228 27.48830 7.12616   1.000 26.57507 ? 106 ALA A CA  1 
ATOM   836  C C   . ALA A 1 111 ? -38.05662 26.81356 8.33568   1.000 31.53621 ? 106 ALA A C   1 
ATOM   837  O O   . ALA A 1 111 ? -38.57389 25.80591 8.84062   1.000 30.71302 ? 106 ALA A O   1 
ATOM   838  C CB  . ALA A 1 111 ? -37.94464 27.12289 5.83505   1.000 20.55968 ? 106 ALA A CB  1 
ATOM   839  N N   . LEU A 1 112 ? -36.94663 27.36936 8.83269   1.000 27.26963 ? 107 LEU A N   1 
ATOM   840  C CA  . LEU A 1 112 ? -36.30861 26.82239 10.03175  1.000 30.66387 ? 107 LEU A CA  1 
ATOM   841  C C   . LEU A 1 112 ? -37.26667 26.79588 11.21193  1.000 32.61308 ? 107 LEU A C   1 
ATOM   842  O O   . LEU A 1 112 ? -37.32673 25.80363 11.95159  1.000 36.04054 ? 107 LEU A O   1 
ATOM   843  C CB  . LEU A 1 112 ? -35.07803 27.64919 10.40668  1.000 34.92371 ? 107 LEU A CB  1 
ATOM   844  C CG  . LEU A 1 112 ? -33.76278 27.45033 9.66151   1.000 31.92245 ? 107 LEU A CG  1 
ATOM   845  C CD1 . LEU A 1 112 ? -32.68662 28.33090 10.30829  1.000 30.92027 ? 107 LEU A CD1 1 
ATOM   846  C CD2 . LEU A 1 112 ? -33.32396 25.99287 9.65023   1.000 31.77776 ? 107 LEU A CD2 1 
ATOM   847  N N   . SER A 1 113 ? -38.01866 27.88134 11.40851  1.000 31.71197 ? 108 SER A N   1 
ATOM   848  C CA  . SER A 1 113 ? -38.95290 27.94269 12.52529  1.000 32.62700 ? 108 SER A CA  1 
ATOM   849  C C   . SER A 1 113 ? -39.96813 26.81401 12.44466  1.000 38.81480 ? 108 SER A C   1 
ATOM   850  O O   . SER A 1 113 ? -40.37032 26.25460 13.47107  1.000 41.00835 ? 108 SER A O   1 
ATOM   851  C CB  . SER A 1 113 ? -39.65941 29.29472 12.53977  1.000 39.37872 ? 108 SER A CB  1 
ATOM   852  O OG  . SER A 1 113 ? -40.36656 29.47932 13.75264  1.000 53.75214 ? 108 SER A OG  1 
ATOM   853  N N   . ALA A 1 114 ? -40.39002 26.46242 11.22941  1.000 32.33574 ? 109 ALA A N   1 
ATOM   854  C CA  . ALA A 1 114 ? -41.37733 25.41183 11.02429  1.000 31.95904 ? 109 ALA A CA  1 
ATOM   855  C C   . ALA A 1 114 ? -40.80042 24.00860 11.14720  1.000 33.11552 ? 109 ALA A C   1 
ATOM   856  O O   . ALA A 1 114 ? -41.57969 23.04973 11.21420  1.000 31.64978 ? 109 ALA A O   1 
ATOM   857  C CB  . ALA A 1 114 ? -42.03328 25.57323 9.65039   1.000 29.18422 ? 109 ALA A CB  1 
ATOM   858  N N   . GLY A 1 115 ? -39.47606 23.86315 11.17144  1.000 27.84127 ? 110 GLY A N   1 
ATOM   859  C CA  . GLY A 1 115 ? -38.82504 22.56669 11.28355  1.000 29.44474 ? 110 GLY A CA  1 
ATOM   860  C C   . GLY A 1 115 ? -37.93425 22.18036 10.11453  1.000 30.45626 ? 110 GLY A C   1 
ATOM   861  O O   . GLY A 1 115 ? -37.35822 21.08410 10.13915  1.000 29.95990 ? 110 GLY A O   1 
ATOM   862  N N   . ALA A 1 116 ? -37.76470 23.01876 9.09429   1.000 32.04090 ? 111 ALA A N   1 
ATOM   863  C CA  . ALA A 1 116 ? -36.87858 22.66639 7.99416   1.000 28.09650 ? 111 ALA A CA  1 
ATOM   864  C C   . ALA A 1 116 ? -35.46916 22.42595 8.51731   1.000 30.56070 ? 111 ALA A C   1 
ATOM   865  O O   . ALA A 1 116 ? -35.02628 23.04032 9.49005   1.000 30.71532 ? 111 ALA A O   1 
ATOM   866  C CB  . ALA A 1 116 ? -36.86078 23.77208 6.93344   1.000 27.83561 ? 111 ALA A CB  1 
ATOM   867  N N   . ASP A 1 117 ? -34.77547 21.48996 7.88976   1.000 26.70115 ? 112 ASP A N   1 
ATOM   868  C CA  . ASP A 1 117 ? -33.41293 21.19505 8.29107   1.000 32.35975 ? 112 ASP A CA  1 
ATOM   869  C C   . ASP A 1 117 ? -32.46891 22.29326 7.81192   1.000 32.36355 ? 112 ASP A C   1 
ATOM   870  O O   . ASP A 1 117 ? -32.62666 22.82531 6.70916   1.000 27.25115 ? 112 ASP A O   1 
ATOM   871  C CB  . ASP A 1 117 ? -32.97129 19.85389 7.72117   1.000 33.49573 ? 112 ASP A CB  1 
ATOM   872  C CG  . ASP A 1 117 ? -31.72430 19.34449 8.38507   1.000 38.99707 ? 112 ASP A CG  1 
ATOM   873  O OD1 . ASP A 1 117 ? -31.83968 18.82207 9.51448   1.000 45.43253 ? 112 ASP A OD1 1 
ATOM   874  O OD2 . ASP A 1 117 ? -30.62909 19.49486 7.80417   1.000 34.83041 ? 112 ASP A OD2 1 
ATOM   875  N N   . VAL A 1 118 ? -31.47306 22.61650 8.64362   1.000 31.00534 ? 113 VAL A N   1 
ATOM   876  C CA  . VAL A 1 118 ? -30.46881 23.61008 8.26773   1.000 31.73220 ? 113 VAL A CA  1 
ATOM   877  C C   . VAL A 1 118 ? -29.83390 23.25539 6.93630   1.000 27.69987 ? 113 VAL A C   1 
ATOM   878  O O   . VAL A 1 118 ? -29.40859 24.14227 6.18180   1.000 29.46724 ? 113 VAL A O   1 
ATOM   879  C CB  . VAL A 1 118 ? -29.40694 23.74385 9.38510   1.000 32.47092 ? 113 VAL A CB  1 
ATOM   880  C CG1 . VAL A 1 118 ? -28.27131 24.67304 8.95264   1.000 29.05902 ? 113 VAL A CG1 1 
ATOM   881  C CG2 . VAL A 1 118 ? -30.04950 24.23786 10.66566  1.000 34.02281 ? 113 VAL A CG2 1 
ATOM   882  N N   . SER A 1 119 ? -29.79737 21.96518 6.59390   1.000 27.38681 ? 114 SER A N   1 
ATOM   883  C CA  . SER A 1 119 ? -29.18603 21.56725 5.33419   1.000 26.58063 ? 114 SER A CA  1 
ATOM   884  C C   . SER A 1 119 ? -29.94549 22.08277 4.12135   1.000 27.90161 ? 114 SER A C   1 
ATOM   885  O O   . SER A 1 119 ? -29.40936 22.00989 3.01048   1.000 27.29866 ? 114 SER A O   1 
ATOM   886  C CB  . SER A 1 119 ? -29.05859 20.04310 5.24627   1.000 31.48623 ? 114 SER A CB  1 
ATOM   887  O OG  . SER A 1 119 ? -30.34036 19.44415 5.28859   1.000 31.34659 ? 114 SER A OG  1 
ATOM   888  N N   . MET A 1 120 ? -31.17268 22.59333 4.29550   1.000 23.06190 ? 115 MET A N   1 
ATOM   889  C CA  . MET A 1 120 ? -31.88285 23.20700 3.16920   1.000 24.47044 ? 115 MET A CA  1 
ATOM   890  C C   . MET A 1 120 ? -31.35188 24.58591 2.78237   1.000 25.52988 ? 115 MET A C   1 
ATOM   891  O O   . MET A 1 120 ? -31.86437 25.17702 1.81686   1.000 22.35767 ? 115 MET A O   1 
ATOM   892  C CB  . MET A 1 120 ? -33.36935 23.33807 3.49040   1.000 26.45472 ? 115 MET A CB  1 
ATOM   893  C CG  . MET A 1 120 ? -34.14637 22.06620 3.31681   1.000 30.87315 ? 115 MET A CG  1 
ATOM   894  S SD  . MET A 1 120 ? -35.88609 22.51519 3.26650   1.000 39.66997 ? 115 MET A SD  1 
ATOM   895  C CE  . MET A 1 120 ? -36.06148 22.98558 1.53064   1.000 31.73092 ? 115 MET A CE  1 
ATOM   896  N N   . ILE A 1 121 ? -30.35047 25.10856 3.49202   1.000 25.56616 ? 116 ILE A N   1 
ATOM   897  C CA  . ILE A 1 121 ? -29.99164 26.51887 3.35722   1.000 22.99223 ? 116 ILE A CA  1 
ATOM   898  C C   . ILE A 1 121 ? -29.62160 26.86547 1.91428   1.000 24.65920 ? 116 ILE A C   1 
ATOM   899  O O   . ILE A 1 121 ? -29.93574 27.95523 1.41994   1.000 23.53426 ? 116 ILE A O   1 
ATOM   900  C CB  . ILE A 1 121 ? -28.85644 26.85804 4.34053   1.000 24.33392 ? 116 ILE A CB  1 
ATOM   901  C CG1 . ILE A 1 121 ? -28.59245 28.36772 4.36832   1.000 22.29053 ? 116 ILE A CG1 1 
ATOM   902  C CG2 . ILE A 1 121 ? -27.58726 26.04515 4.02377   1.000 21.72807 ? 116 ILE A CG2 1 
ATOM   903  C CD1 . ILE A 1 121 ? -27.61516 28.74089 5.43944   1.000 21.39125 ? 116 ILE A CD1 1 
ATOM   904  N N   . GLY A 1 122 ? -28.97302 25.94596 1.20364   1.000 23.64921 ? 117 GLY A N   1 
ATOM   905  C CA  . GLY A 1 122 ? -28.56098 26.25133 -0.15531  1.000 22.83494 ? 117 GLY A CA  1 
ATOM   906  C C   . GLY A 1 122 ? -29.71612 26.44053 -1.12356  1.000 27.73092 ? 117 GLY A C   1 
ATOM   907  O O   . GLY A 1 122 ? -29.58740 27.16275 -2.11811  1.000 21.59784 ? 117 GLY A O   1 
ATOM   908  N N   . GLN A 1 123 ? -30.84824 25.78322 -0.87058  1.000 21.54573 ? 118 GLN A N   1 
ATOM   909  C CA  . GLN A 1 123 ? -31.99886 25.95000 -1.75403  1.000 23.61388 ? 118 GLN A CA  1 
ATOM   910  C C   . GLN A 1 123 ? -32.67462 27.30658 -1.56553  1.000 22.52973 ? 118 GLN A C   1 
ATOM   911  O O   . GLN A 1 123 ? -33.45257 27.72890 -2.42882  1.000 25.47507 ? 118 GLN A O   1 
ATOM   912  C CB  . GLN A 1 123 ? -32.99404 24.80205 -1.53167  1.000 26.20600 ? 118 GLN A CB  1 
ATOM   913  C CG  . GLN A 1 123 ? -32.44571 23.45028 -1.98196  1.000 29.14755 ? 118 GLN A CG  1 
ATOM   914  C CD  . GLN A 1 123 ? -33.38144 22.30939 -1.67343  1.000 30.89275 ? 118 GLN A CD  1 
ATOM   915  O OE1 . GLN A 1 123 ? -34.42096 22.15962 -2.31538  1.000 34.12537 ? 118 GLN A OE1 1 
ATOM   916  N NE2 . GLN A 1 123 ? -33.01749 21.48987 -0.69056  1.000 32.10850 ? 118 GLN A NE2 1 
ATOM   917  N N   . PHE A 1 124 ? -32.39116 28.00039 -0.46885  1.000 20.86509 ? 119 PHE A N   1 
ATOM   918  C CA  . PHE A 1 124 ? -32.83025 29.38225 -0.28960  1.000 21.57390 ? 119 PHE A CA  1 
ATOM   919  C C   . PHE A 1 124 ? -31.77776 30.39497 -0.73644  1.000 25.81681 ? 119 PHE A C   1 
ATOM   920  O O   . PHE A 1 124 ? -31.97195 31.60476 -0.54959  1.000 24.08559 ? 119 PHE A O   1 
ATOM   921  C CB  . PHE A 1 124 ? -33.21959 29.62335 1.17123   1.000 23.87652 ? 119 PHE A CB  1 
ATOM   922  C CG  . PHE A 1 124 ? -34.49576 28.92851 1.56783   1.000 25.41288 ? 119 PHE A CG  1 
ATOM   923  C CD1 . PHE A 1 124 ? -34.48350 27.59320 1.96005   1.000 25.46145 ? 119 PHE A CD1 1 
ATOM   924  C CD2 . PHE A 1 124 ? -35.70777 29.60893 1.53511   1.000 23.07647 ? 119 PHE A CD2 1 
ATOM   925  C CE1 . PHE A 1 124 ? -35.67085 26.94471 2.31001   1.000 28.14906 ? 119 PHE A CE1 1 
ATOM   926  C CE2 . PHE A 1 124 ? -36.89345 28.97374 1.88368   1.000 24.06110 ? 119 PHE A CE2 1 
ATOM   927  C CZ  . PHE A 1 124 ? -36.88106 27.64917 2.27403   1.000 24.63142 ? 119 PHE A CZ  1 
ATOM   928  N N   . GLY A 1 125 ? -30.67572 29.92951 -1.32565  1.000 22.01976 ? 120 GLY A N   1 
ATOM   929  C CA  . GLY A 1 125 ? -29.67070 30.82571 -1.86730  1.000 23.77006 ? 120 GLY A CA  1 
ATOM   930  C C   . GLY A 1 125 ? -28.77588 31.50900 -0.85498  1.000 22.43866 ? 120 GLY A C   1 
ATOM   931  O O   . GLY A 1 125 ? -28.06368 32.45237 -1.22776  1.000 22.57702 ? 120 GLY A O   1 
ATOM   932  N N   . VAL A 1 126 ? -28.76450 31.06271 0.40323   1.000 22.91359 ? 121 VAL A N   1 
ATOM   933  C CA  . VAL A 1 126 ? -27.98471 31.74238 1.43669   1.000 20.75648 ? 121 VAL A CA  1 
ATOM   934  C C   . VAL A 1 126 ? -27.03111 30.76117 2.11362   1.000 20.81412 ? 121 VAL A C   1 
ATOM   935  O O   . VAL A 1 126 ? -26.65605 30.94495 3.27391   1.000 22.65643 ? 121 VAL A O   1 
ATOM   936  C CB  . VAL A 1 126 ? -28.90739 32.43786 2.45915   1.000 23.85286 ? 121 VAL A CB  1 
ATOM   937  C CG1 . VAL A 1 126 ? -29.65843 33.58416 1.78686   1.000 26.32904 ? 121 VAL A CG1 1 
ATOM   938  C CG2 . VAL A 1 126 ? -29.90707 31.45135 3.05742   1.000 21.73838 ? 121 VAL A CG2 1 
ATOM   939  N N   . GLY A 1 127 ? -26.59563 29.73673 1.37314   1.000 19.66543 ? 122 GLY A N   1 
ATOM   940  C CA  . GLY A 1 127 ? -25.66666 28.75358 1.91193   1.000 18.98431 ? 122 GLY A CA  1 
ATOM   941  C C   . GLY A 1 127 ? -24.34298 29.33121 2.39063   1.000 20.24853 ? 122 GLY A C   1 
ATOM   942  O O   . GLY A 1 127 ? -23.68320 28.72240 3.23664   1.000 21.72102 ? 122 GLY A O   1 
ATOM   943  N N   . PHE A 1 128 ? -23.95401 30.50658 1.88920   1.000 20.90295 ? 123 PHE A N   1 
ATOM   944  C CA  . PHE A 1 128 ? -22.72432 31.14663 2.35427   1.000 20.25138 ? 123 PHE A CA  1 
ATOM   945  C C   . PHE A 1 128 ? -22.67367 31.23388 3.87245   1.000 21.69633 ? 123 PHE A C   1 
ATOM   946  O O   . PHE A 1 128 ? -21.62500 30.98618 4.48978   1.000 20.02154 ? 123 PHE A O   1 
ATOM   947  C CB  . PHE A 1 128 ? -22.61943 32.55013 1.74297   1.000 21.80417 ? 123 PHE A CB  1 
ATOM   948  C CG  . PHE A 1 128 ? -21.55541 33.41986 2.37227   1.000 21.14465 ? 123 PHE A CG  1 
ATOM   949  C CD1 . PHE A 1 128 ? -20.22045 33.28714 1.99953   1.000 22.96200 ? 123 PHE A CD1 1 
ATOM   950  C CD2 . PHE A 1 128 ? -21.89063 34.37775 3.31884   1.000 21.74617 ? 123 PHE A CD2 1 
ATOM   951  C CE1 . PHE A 1 128 ? -19.23809 34.09639 2.57373   1.000 25.46686 ? 123 PHE A CE1 1 
ATOM   952  C CE2 . PHE A 1 128 ? -20.91317 35.19345 3.90309   1.000 23.96181 ? 123 PHE A CE2 1 
ATOM   953  C CZ  . PHE A 1 128 ? -19.58886 35.06121 3.52069   1.000 21.64592 ? 123 PHE A CZ  1 
ATOM   954  N N   . TYR A 1 129 ? -23.80368 31.58360 4.49552   1.000 21.04524 ? 124 TYR A N   1 
ATOM   955  C CA  . TYR A 1 129 ? -23.83998 31.85415 5.92847   1.000 20.16648 ? 124 TYR A CA  1 
ATOM   956  C C   . TYR A 1 129 ? -23.74524 30.58539 6.76264   1.000 20.31033 ? 124 TYR A C   1 
ATOM   957  O O   . TYR A 1 129 ? -23.54003 30.68026 7.97427   1.000 21.39972 ? 124 TYR A O   1 
ATOM   958  C CB  . TYR A 1 129 ? -25.10630 32.66678 6.26709   1.000 22.54503 ? 124 TYR A CB  1 
ATOM   959  C CG  . TYR A 1 129 ? -25.12644 33.98517 5.52301   1.000 19.90684 ? 124 TYR A CG  1 
ATOM   960  C CD1 . TYR A 1 129 ? -24.34466 35.06392 5.94762   1.000 22.91708 ? 124 TYR A CD1 1 
ATOM   961  C CD2 . TYR A 1 129 ? -25.88544 34.14259 4.36758   1.000 21.01330 ? 124 TYR A CD2 1 
ATOM   962  C CE1 . TYR A 1 129 ? -24.34072 36.27595 5.24124   1.000 21.84583 ? 124 TYR A CE1 1 
ATOM   963  C CE2 . TYR A 1 129 ? -25.88267 35.34308 3.66260   1.000 24.54211 ? 124 TYR A CE2 1 
ATOM   964  C CZ  . TYR A 1 129 ? -25.11815 36.40569 4.10591   1.000 24.00958 ? 124 TYR A CZ  1 
ATOM   965  O OH  . TYR A 1 129 ? -25.12693 37.59116 3.38218   1.000 28.16761 ? 124 TYR A OH  1 
ATOM   966  N N   . SER A 1 130 ? -23.82507 29.40663 6.13209   1.000 19.41054 ? 125 SER A N   1 
ATOM   967  C CA  . SER A 1 130 ? -23.58603 28.15898 6.83880   1.000 19.60726 ? 125 SER A CA  1 
ATOM   968  C C   . SER A 1 130 ? -22.16899 28.07169 7.38738   1.000 21.46043 ? 125 SER A C   1 
ATOM   969  O O   . SER A 1 130 ? -21.91039 27.23551 8.25572   1.000 20.24997 ? 125 SER A O   1 
ATOM   970  C CB  . SER A 1 130 ? -23.84303 26.96235 5.91649   1.000 22.19906 ? 125 SER A CB  1 
ATOM   971  O OG  . SER A 1 130 ? -22.82066 26.84395 4.92180   1.000 24.54093 ? 125 SER A OG  1 
ATOM   972  N N   . LEU A 1 131 ? -21.24360 28.91489 6.90816   1.000 21.32213 ? 126 LEU A N   1 
ATOM   973  C CA  . LEU A 1 131 ? -19.88959 28.88503 7.45527   1.000 21.22194 ? 126 LEU A CA  1 
ATOM   974  C C   . LEU A 1 131 ? -19.89932 29.16052 8.95498   1.000 21.24625 ? 126 LEU A C   1 
ATOM   975  O O   . LEU A 1 131 ? -19.00852 28.70365 9.67891   1.000 20.69469 ? 126 LEU A O   1 
ATOM   976  C CB  . LEU A 1 131 ? -18.99847 29.89396 6.71891   1.000 18.77502 ? 126 LEU A CB  1 
ATOM   977  C CG  . LEU A 1 131 ? -19.21102 31.39881 6.93301   1.000 21.05312 ? 126 LEU A CG  1 
ATOM   978  C CD1 . LEU A 1 131 ? -18.35588 31.89502 8.07686   1.000 23.22044 ? 126 LEU A CD1 1 
ATOM   979  C CD2 . LEU A 1 131 ? -18.86675 32.14971 5.65656   1.000 21.43924 ? 126 LEU A CD2 1 
ATOM   980  N N   . PHE A 1 132 ? -20.92038 29.85778 9.45050   1.000 20.14937 ? 127 PHE A N   1 
ATOM   981  C CA  . PHE A 1 132 ? -20.93717 30.16998 10.87005  1.000 22.54194 ? 127 PHE A CA  1 
ATOM   982  C C   . PHE A 1 132 ? -21.29678 28.96602 11.73971  1.000 25.85670 ? 127 PHE A C   1 
ATOM   983  O O   . PHE A 1 132 ? -21.20097 29.06012 12.96852  1.000 25.62887 ? 127 PHE A O   1 
ATOM   984  C CB  . PHE A 1 132 ? -21.86597 31.35908 11.11768  1.000 22.78007 ? 127 PHE A CB  1 
ATOM   985  C CG  . PHE A 1 132 ? -21.30091 32.66440 10.60965  1.000 23.81050 ? 127 PHE A CG  1 
ATOM   986  C CD1 . PHE A 1 132 ? -20.23476 33.27089 11.26978  1.000 24.99779 ? 127 PHE A CD1 1 
ATOM   987  C CD2 . PHE A 1 132 ? -21.81155 33.26776 9.46920   1.000 23.77400 ? 127 PHE A CD2 1 
ATOM   988  C CE1 . PHE A 1 132 ? -19.70288 34.45902 10.81562  1.000 24.34602 ? 127 PHE A CE1 1 
ATOM   989  C CE2 . PHE A 1 132 ? -21.27602 34.46872 9.00014   1.000 28.13149 ? 127 PHE A CE2 1 
ATOM   990  C CZ  . PHE A 1 132 ? -20.21388 35.05842 9.67788   1.000 26.11304 ? 127 PHE A CZ  1 
ATOM   991  N N   . LEU A 1 133 ? -21.65387 27.82585 11.13600  1.000 22.63895 ? 128 LEU A N   1 
ATOM   992  C CA  . LEU A 1 133 ? -21.75456 26.58438 11.89977  1.000 21.99089 ? 128 LEU A CA  1 
ATOM   993  C C   . LEU A 1 133 ? -20.41460 26.16930 12.49969  1.000 30.05942 ? 128 LEU A C   1 
ATOM   994  O O   . LEU A 1 133 ? -20.37536 25.57130 13.58185  1.000 26.28116 ? 128 LEU A O   1 
ATOM   995  C CB  . LEU A 1 133 ? -22.29788 25.46563 11.01004  1.000 24.15245 ? 128 LEU A CB  1 
ATOM   996  C CG  . LEU A 1 133 ? -23.73027 25.68734 10.50236  1.000 26.48299 ? 128 LEU A CG  1 
ATOM   997  C CD1 . LEU A 1 133 ? -24.08997 24.69680 9.40466   1.000 25.52574 ? 128 LEU A CD1 1 
ATOM   998  C CD2 . LEU A 1 133 ? -24.70335 25.57657 11.66438  1.000 28.10950 ? 128 LEU A CD2 1 
ATOM   999  N N   . VAL A 1 134 ? -19.30692 26.44998 11.81384  1.000 25.01061 ? 129 VAL A N   1 
ATOM   1000 C CA  . VAL A 1 134 ? -18.00193 25.96653 12.24622  1.000 23.96106 ? 129 VAL A CA  1 
ATOM   1001 C C   . VAL A 1 134 ? -17.00554 27.08321 12.49376  1.000 24.78411 ? 129 VAL A C   1 
ATOM   1002 O O   . VAL A 1 134 ? -15.92083 26.80942 13.02744  1.000 25.37039 ? 129 VAL A O   1 
ATOM   1003 C CB  . VAL A 1 134 ? -17.41210 24.95873 11.23852  1.000 24.89417 ? 129 VAL A CB  1 
ATOM   1004 C CG1 . VAL A 1 134 ? -18.31976 23.72999 11.10826  1.000 26.43155 ? 129 VAL A CG1 1 
ATOM   1005 C CG2 . VAL A 1 134 ? -17.17627 25.63782 9.86882   1.000 23.41866 ? 129 VAL A CG2 1 
ATOM   1006 N N   . ALA A 1 135 ? -17.32039 28.32493 12.13243  1.000 23.88880 ? 130 ALA A N   1 
ATOM   1007 C CA  . ALA A 1 135 ? -16.35728 29.41612 12.22294  1.000 25.58500 ? 130 ALA A CA  1 
ATOM   1008 C C   . ALA A 1 135 ? -16.94132 30.55188 13.05323  1.000 25.16898 ? 130 ALA A C   1 
ATOM   1009 O O   . ALA A 1 135 ? -18.13869 30.83455 12.96638  1.000 26.16182 ? 130 ALA A O   1 
ATOM   1010 C CB  . ALA A 1 135 ? -15.96796 29.91376 10.80968  1.000 21.12621 ? 130 ALA A CB  1 
ATOM   1011 N N   . ASP A 1 136 ? -16.09094 31.19579 13.87136  1.000 22.78374 ? 131 ASP A N   1 
ATOM   1012 C CA  . ASP A 1 136 ? -16.48750 32.39197 14.61338  1.000 26.16667 ? 131 ASP A CA  1 
ATOM   1013 C C   . ASP A 1 136 ? -16.37236 33.65870 13.78206  1.000 29.14425 ? 131 ASP A C   1 
ATOM   1014 O O   . ASP A 1 136 ? -16.98945 34.67440 14.12536  1.000 27.48009 ? 131 ASP A O   1 
ATOM   1015 C CB  . ASP A 1 136 ? -15.60766 32.58371 15.85909  1.000 28.83567 ? 131 ASP A CB  1 
ATOM   1016 C CG  . ASP A 1 136 ? -15.86499 31.55063 16.92691  1.000 42.23529 ? 131 ASP A CG  1 
ATOM   1017 O OD1 . ASP A 1 136 ? -17.05005 31.21532 17.15698  1.000 41.09682 ? 131 ASP A OD1 1 
ATOM   1018 O OD2 . ASP A 1 136 ? -14.87639 31.07835 17.54190  1.000 44.69153 ? 131 ASP A OD2 1 
ATOM   1019 N N   . ARG A 1 137 ? -15.56005 33.63017 12.72920  1.000 22.17458 ? 132 ARG A N   1 
ATOM   1020 C CA  . ARG A 1 137 ? -15.21473 34.82816 11.98366  1.000 23.78791 ? 132 ARG A CA  1 
ATOM   1021 C C   . ARG A 1 137 ? -14.82026 34.38432 10.58421  1.000 22.34327 ? 132 ARG A C   1 
ATOM   1022 O O   . ARG A 1 137 ? -14.36368 33.25705 10.39239  1.000 24.30589 ? 132 ARG A O   1 
ATOM   1023 C CB  . ARG A 1 137 ? -14.06292 35.57621 12.67319  1.000 26.45308 ? 132 ARG A CB  1 
ATOM   1024 C CG  . ARG A 1 137 ? -13.56095 36.80624 11.95524  1.000 33.40048 ? 132 ARG A CG  1 
ATOM   1025 C CD  . ARG A 1 137 ? -12.75802 37.68789 12.91228  1.000 36.80647 ? 132 ARG A CD  1 
ATOM   1026 N NE  . ARG A 1 137 ? -11.50780 37.07339 13.33763  1.000 42.83924 ? 132 ARG A NE  1 
ATOM   1027 C CZ  . ARG A 1 137 ? -10.30358 37.45776 12.92507  1.000 46.34599 ? 132 ARG A CZ  1 
ATOM   1028 N NH1 . ARG A 1 137 ? -10.15283 38.41223 12.02011  1.000 44.99188 ? 132 ARG A NH1 1 
ATOM   1029 N NH2 . ARG A 1 137 ? -9.22127  36.88397 13.44867  1.000 44.21756 ? 132 ARG A NH2 1 
ATOM   1030 N N   . VAL A 1 138 ? -15.00658 35.26734 9.61182   1.000 23.78014 ? 133 VAL A N   1 
ATOM   1031 C CA  . VAL A 1 138 ? -14.66187 34.94956 8.23454   1.000 23.24460 ? 133 VAL A CA  1 
ATOM   1032 C C   . VAL A 1 138 ? -14.08033 36.19040 7.58811   1.000 22.84985 ? 133 VAL A C   1 
ATOM   1033 O O   . VAL A 1 138 ? -14.55280 37.31103 7.81618   1.000 24.70620 ? 133 VAL A O   1 
ATOM   1034 C CB  . VAL A 1 138 ? -15.87893 34.41168 7.43598   1.000 21.21177 ? 133 VAL A CB  1 
ATOM   1035 C CG1 . VAL A 1 138 ? -17.03757 35.40828 7.45152   1.000 23.94744 ? 133 VAL A CG1 1 
ATOM   1036 C CG2 . VAL A 1 138 ? -15.48764 34.10120 5.98246   1.000 21.98044 ? 133 VAL A CG2 1 
ATOM   1037 N N   . GLN A 1 139 ? -13.02610 35.98824 6.80423   1.000 19.57463 ? 134 GLN A N   1 
ATOM   1038 C CA  . GLN A 1 139 ? -12.57226 36.96931 5.83988   1.000 22.37110 ? 134 GLN A CA  1 
ATOM   1039 C C   . GLN A 1 139 ? -12.85765 36.42220 4.45053   1.000 21.59587 ? 134 GLN A C   1 
ATOM   1040 O O   . GLN A 1 139 ? -12.45605 35.29929 4.13031   1.000 21.28495 ? 134 GLN A O   1 
ATOM   1041 C CB  . GLN A 1 139 ? -11.07506 37.26189 6.00385   1.000 22.75251 ? 134 GLN A CB  1 
ATOM   1042 C CG  . GLN A 1 139 ? -10.77074 38.08864 7.23851   1.000 24.91561 ? 134 GLN A CG  1 
ATOM   1043 C CD  . GLN A 1 139 ? -9.27921  38.17559 7.50856   1.000 31.04004 ? 134 GLN A CD  1 
ATOM   1044 O OE1 . GLN A 1 139 ? -8.48403  37.49997 6.85311   1.000 27.76388 ? 134 GLN A OE1 1 
ATOM   1045 N NE2 . GLN A 1 139 ? -8.89638  38.99399 8.48813   1.000 30.53846 ? 134 GLN A NE2 1 
ATOM   1046 N N   . VAL A 1 140 ? -13.56203 37.20719 3.64532   1.000 19.67282 ? 135 VAL A N   1 
ATOM   1047 C CA  . VAL A 1 140 ? -13.73768 36.91368 2.23189   1.000 19.16592 ? 135 VAL A CA  1 
ATOM   1048 C C   . VAL A 1 140 ? -12.77858 37.82448 1.48931   1.000 19.38124 ? 135 VAL A C   1 
ATOM   1049 O O   . VAL A 1 140 ? -12.98210 39.03786 1.44665   1.000 20.84879 ? 135 VAL A O   1 
ATOM   1050 C CB  . VAL A 1 140 ? -15.17986 37.13418 1.76883   1.000 21.04107 ? 135 VAL A CB  1 
ATOM   1051 C CG1 . VAL A 1 140 ? -15.27383 36.92352 0.26633   1.000 18.63350 ? 135 VAL A CG1 1 
ATOM   1052 C CG2 . VAL A 1 140 ? -16.12615 36.18146 2.51295   1.000 19.51674 ? 135 VAL A CG2 1 
ATOM   1053 N N   . ILE A 1 141 ? -11.72522 37.23487 0.94407   1.000 18.89021 ? 136 ILE A N   1 
ATOM   1054 C CA  . ILE A 1 141 ? -10.71748 37.92968 0.15824   1.000 19.54392 ? 136 ILE A CA  1 
ATOM   1055 C C   . ILE A 1 141 ? -11.07088 37.71287 -1.30401  1.000 19.29017 ? 136 ILE A C   1 
ATOM   1056 O O   . ILE A 1 141 ? -11.13045 36.56754 -1.75261  1.000 21.41954 ? 136 ILE A O   1 
ATOM   1057 C CB  . ILE A 1 141 ? -9.32151  37.37872 0.48506   1.000 23.07312 ? 136 ILE A CB  1 
ATOM   1058 C CG1 . ILE A 1 141 ? -9.10440  37.45677 2.01666   1.000 21.65145 ? 136 ILE A CG1 1 
ATOM   1059 C CG2 . ILE A 1 141 ? -8.25736  38.11445 -0.33312  1.000 23.67403 ? 136 ILE A CG2 1 
ATOM   1060 C CD1 . ILE A 1 141 ? -8.01957  36.53537 2.55835   1.000 24.89293 ? 136 ILE A CD1 1 
ATOM   1061 N N   . SER A 1 142 ? -11.31568 38.78688 -2.06103  1.000 21.24454 ? 137 SER A N   1 
ATOM   1062 C CA  . SER A 1 142 ? -11.81646 38.57940 -3.41176  1.000 21.37347 ? 137 SER A CA  1 
ATOM   1063 C C   . SER A 1 142 ? -11.15424 39.52157 -4.40211  1.000 22.18023 ? 137 SER A C   1 
ATOM   1064 O O   . SER A 1 142 ? -10.86410 40.67743 -4.08019  1.000 21.33225 ? 137 SER A O   1 
ATOM   1065 C CB  . SER A 1 142 ? -13.34149 38.75297 -3.47190  1.000 25.18637 ? 137 SER A CB  1 
ATOM   1066 O OG  . SER A 1 142 ? -13.87939 38.09385 -4.61677  1.000 24.20354 ? 137 SER A OG  1 
ATOM   1067 N N   . LYS A 1 143 ? -10.93360 39.00549 -5.61307  1.000 20.61897 ? 138 LYS A N   1 
ATOM   1068 C CA  . LYS A 1 143 ? -10.33757 39.74371 -6.72133  1.000 20.51767 ? 138 LYS A CA  1 
ATOM   1069 C C   . LYS A 1 143 ? -11.16977 39.50233 -7.97191  1.000 19.64616 ? 138 LYS A C   1 
ATOM   1070 O O   . LYS A 1 143 ? -11.13727 38.40357 -8.54011  1.000 18.80436 ? 138 LYS A O   1 
ATOM   1071 C CB  . LYS A 1 143 ? -8.90119  39.29850 -6.97204  1.000 22.82076 ? 138 LYS A CB  1 
ATOM   1072 C CG  . LYS A 1 143 ? -8.27280  39.98836 -8.19204  1.000 23.28053 ? 138 LYS A CG  1 
ATOM   1073 C CD  . LYS A 1 143 ? -8.10168  41.49019 -7.93127  1.000 22.64875 ? 138 LYS A CD  1 
ATOM   1074 C CE  . LYS A 1 143 ? -7.35849  42.19254 -9.08523  1.000 25.35174 ? 138 LYS A CE  1 
ATOM   1075 N NZ  . LYS A 1 143 ? -8.16713  42.21693 -10.34743 1.000 24.23264 ? 138 LYS A NZ  1 
ATOM   1076 N N   . ASN A 1 144 ? -11.86028 40.53512 -8.42250  1.000 20.10084 ? 139 ASN A N   1 
ATOM   1077 C CA  . ASN A 1 144 ? -12.59954 40.51139 -9.67723  1.000 24.26052 ? 139 ASN A CA  1 
ATOM   1078 C C   . ASN A 1 144 ? -11.75756 41.22156 -10.72503 1.000 24.86188 ? 139 ASN A C   1 
ATOM   1079 O O   . ASN A 1 144 ? -10.99644 42.13626 -10.40091 1.000 25.49101 ? 139 ASN A O   1 
ATOM   1080 C CB  . ASN A 1 144 ? -13.95522 41.21065 -9.50113  1.000 23.17038 ? 139 ASN A CB  1 
ATOM   1081 C CG  . ASN A 1 144 ? -14.76538 41.29080 -10.78470 1.000 26.58481 ? 139 ASN A CG  1 
ATOM   1082 O OD1 . ASN A 1 144 ? -14.51696 42.14782 -11.63492 1.000 23.62615 ? 139 ASN A OD1 1 
ATOM   1083 N ND2 . ASN A 1 144 ? -15.77601 40.42953 -10.90603 1.000 24.92602 ? 139 ASN A ND2 1 
ATOM   1084 N N   . ASN A 1 145 ? -11.91146 40.81523 -11.99068 1.000 23.41551 ? 140 ASN A N   1 
ATOM   1085 C CA  . ASN A 1 145 ? -11.09554 41.41127 -13.04381 1.000 24.63149 ? 140 ASN A CA  1 
ATOM   1086 C C   . ASN A 1 145 ? -11.24312 42.92856 -13.11274 1.000 26.64008 ? 140 ASN A C   1 
ATOM   1087 O O   . ASN A 1 145 ? -10.32656 43.60442 -13.58778 1.000 27.24470 ? 140 ASN A O   1 
ATOM   1088 C CB  . ASN A 1 145 ? -11.44511 40.78513 -14.40397 1.000 24.77113 ? 140 ASN A CB  1 
ATOM   1089 C CG  . ASN A 1 145 ? -10.83197 39.40079 -14.59269 1.000 29.50642 ? 140 ASN A CG  1 
ATOM   1090 O OD1 . ASN A 1 145 ? -10.03359 38.94371 -13.76798 1.000 24.53852 ? 140 ASN A OD1 1 
ATOM   1091 N ND2 . ASN A 1 145 ? -11.18999 38.72846 -15.70085 1.000 24.44501 ? 140 ASN A ND2 1 
ATOM   1092 N N   . ASP A 1 146 ? -12.36006 43.48662 -12.64376 1.000 25.86932 ? 141 ASP A N   1 
ATOM   1093 C CA  . ASP A 1 146 ? -12.63206 44.91329 -12.78510 1.000 27.69660 ? 141 ASP A CA  1 
ATOM   1094 C C   . ASP A 1 146 ? -12.34856 45.73076 -11.52756 1.000 28.51271 ? 141 ASP A C   1 
ATOM   1095 O O   . ASP A 1 146 ? -12.75296 46.89784 -11.46554 1.000 29.64419 ? 141 ASP A O   1 
ATOM   1096 C CB  . ASP A 1 146 ? -14.09139 45.13256 -13.19256 1.000 29.70157 ? 141 ASP A CB  1 
ATOM   1097 C CG  . ASP A 1 146 ? -14.39879 44.61779 -14.58957 1.000 36.26308 ? 141 ASP A CG  1 
ATOM   1098 O OD1 . ASP A 1 146 ? -13.48518 44.59592 -15.44035 1.000 39.60274 ? 141 ASP A OD1 1 
ATOM   1099 O OD2 . ASP A 1 146 ? -15.56348 44.24534 -14.83665 1.000 45.25142 ? 141 ASP A OD2 1 
ATOM   1100 N N   . ASP A 1 147 ? -11.69476 45.16443 -10.51503 1.000 26.11896 ? 142 ASP A N   1 
ATOM   1101 C CA  . ASP A 1 147 ? -11.45115 45.92990 -9.29678  1.000 25.26236 ? 142 ASP A CA  1 
ATOM   1102 C C   . ASP A 1 147 ? -10.16629 45.43117 -8.66171  1.000 25.85718 ? 142 ASP A C   1 
ATOM   1103 O O   . ASP A 1 147 ? -9.57178  44.45088 -9.10937  1.000 27.03638 ? 142 ASP A O   1 
ATOM   1104 C CB  . ASP A 1 147 ? -12.63457 45.82337 -8.31836  1.000 25.16718 ? 142 ASP A CB  1 
ATOM   1105 C CG  . ASP A 1 147 ? -12.70450 46.98624 -7.32176  1.000 31.12653 ? 142 ASP A CG  1 
ATOM   1106 O OD1 . ASP A 1 147 ? -11.78107 47.83640 -7.29992  1.000 27.52016 ? 142 ASP A OD1 1 
ATOM   1107 O OD2 . ASP A 1 147 ? -13.69487 47.04041 -6.54818  1.000 29.15065 ? 142 ASP A OD2 1 
ATOM   1108 N N   . GLU A 1 148 ? -9.72861  46.14156 -7.62105  1.000 26.20727 ? 143 GLU A N   1 
ATOM   1109 C CA  . GLU A 1 148 ? -8.61890  45.68631 -6.79332  1.000 27.19434 ? 143 GLU A CA  1 
ATOM   1110 C C   . GLU A 1 148 ? -9.08254  44.57278 -5.85424  1.000 26.02908 ? 143 GLU A C   1 
ATOM   1111 O O   . GLU A 1 148 ? -10.27677 44.28538 -5.72957  1.000 24.43186 ? 143 GLU A O   1 
ATOM   1112 C CB  . GLU A 1 148 ? -8.04490  46.84827 -5.97822  1.000 28.02049 ? 143 GLU A CB  1 
ATOM   1113 C CG  . GLU A 1 148 ? -7.56065  48.01742 -6.82833  1.000 33.82174 ? 143 GLU A CG  1 
ATOM   1114 C CD  . GLU A 1 148 ? -6.43699  47.62261 -7.77627  1.000 41.60261 ? 143 GLU A CD  1 
ATOM   1115 O OE1 . GLU A 1 148 ? -5.52835  46.87712 -7.34827  1.000 42.45699 ? 143 GLU A OE1 1 
ATOM   1116 O OE2 . GLU A 1 148 ? -6.46557  48.05489 -8.95207  1.000 49.43391 ? 143 GLU A OE2 1 
ATOM   1117 N N   . GLN A 1 149 ? -8.11716  43.94777 -5.18082  1.000 23.44913 ? 144 GLN A N   1 
ATOM   1118 C CA  . GLN A 1 149 ? -8.41985  42.91541 -4.19796  1.000 24.83669 ? 144 GLN A CA  1 
ATOM   1119 C C   . GLN A 1 149 ? -8.86897  43.53940 -2.88277  1.000 27.82614 ? 144 GLN A C   1 
ATOM   1120 O O   . GLN A 1 149 ? -8.21933  44.45944 -2.36548  1.000 26.66142 ? 144 GLN A O   1 
ATOM   1121 C CB  . GLN A 1 149 ? -7.19604  42.03688 -3.97188  1.000 24.54982 ? 144 GLN A CB  1 
ATOM   1122 C CG  . GLN A 1 149 ? -7.44808  40.85257 -3.04732  1.000 24.40443 ? 144 GLN A CG  1 
ATOM   1123 C CD  . GLN A 1 149 ? -6.34094  39.84555 -3.16604  1.000 27.04318 ? 144 GLN A CD  1 
ATOM   1124 O OE1 . GLN A 1 149 ? -5.97754  39.43418 -4.28104  1.000 24.41799 ? 144 GLN A OE1 1 
ATOM   1125 N NE2 . GLN A 1 149 ? -5.78092  39.44041 -2.02691  1.000 22.39371 ? 144 GLN A NE2 1 
ATOM   1126 N N   . TYR A 1 150 ? -9.96474  43.01649 -2.32503  1.000 25.08514 ? 145 TYR A N   1 
ATOM   1127 C CA  . TYR A 1 150 ? -10.57581 43.56139 -1.12064  1.000 25.16357 ? 145 TYR A CA  1 
ATOM   1128 C C   . TYR A 1 150 ? -10.83445 42.45105 -0.11498  1.000 21.13359 ? 145 TYR A C   1 
ATOM   1129 O O   . TYR A 1 150 ? -10.96460 41.27959 -0.47683  1.000 21.48975 ? 145 TYR A O   1 
ATOM   1130 C CB  . TYR A 1 150 ? -11.89686 44.28470 -1.42274  1.000 24.61904 ? 145 TYR A CB  1 
ATOM   1131 C CG  . TYR A 1 150 ? -11.69226 45.69157 -1.91081  1.000 25.30430 ? 145 TYR A CG  1 
ATOM   1132 C CD1 . TYR A 1 150 ? -11.58681 46.74634 -1.01546  1.000 26.18437 ? 145 TYR A CD1 1 
ATOM   1133 C CD2 . TYR A 1 150 ? -11.58501 45.96298 -3.26582  1.000 25.44927 ? 145 TYR A CD2 1 
ATOM   1134 C CE1 . TYR A 1 150 ? -11.38269 48.03680 -1.45801  1.000 30.02349 ? 145 TYR A CE1 1 
ATOM   1135 C CE2 . TYR A 1 150 ? -11.38076 47.25579 -3.72184  1.000 30.89465 ? 145 TYR A CE2 1 
ATOM   1136 C CZ  . TYR A 1 150 ? -11.28130 48.28584 -2.81114  1.000 28.70733 ? 145 TYR A CZ  1 
ATOM   1137 O OH  . TYR A 1 150 ? -11.08092 49.57668 -3.26113  1.000 30.37047 ? 145 TYR A OH  1 
ATOM   1138 N N   . ILE A 1 151 ? -10.91379 42.84091 1.15857   1.000 22.68910 ? 146 ILE A N   1 
ATOM   1139 C CA  . ILE A 1 151 ? -11.19359 41.92892 2.26438   1.000 21.68859 ? 146 ILE A CA  1 
ATOM   1140 C C   . ILE A 1 151 ? -12.48587 42.36281 2.93668   1.000 24.21788 ? 146 ILE A C   1 
ATOM   1141 O O   . ILE A 1 151 ? -12.56459 43.46683 3.49477   1.000 23.59672 ? 146 ILE A O   1 
ATOM   1142 C CB  . ILE A 1 151 ? -10.06558 41.89675 3.30532   1.000 22.25178 ? 146 ILE A CB  1 
ATOM   1143 C CG1 . ILE A 1 151 ? -8.69733  41.68403 2.64798   1.000 25.32432 ? 146 ILE A CG1 1 
ATOM   1144 C CG2 . ILE A 1 151 ? -10.35254 40.80833 4.34981   1.000 23.30229 ? 146 ILE A CG2 1 
ATOM   1145 C CD1 . ILE A 1 151 ? -7.53766  42.03957 3.57099   1.000 26.06327 ? 146 ILE A CD1 1 
ATOM   1146 N N   . TRP A 1 152 ? -13.47352 41.47360 2.92548   1.000 23.58530 ? 147 TRP A N   1 
ATOM   1147 C CA  . TRP A 1 152 ? -14.72089 41.62434 3.65772   1.000 21.75667 ? 147 TRP A CA  1 
ATOM   1148 C C   . TRP A 1 152 ? -14.60465 40.76099 4.90792   1.000 22.71165 ? 147 TRP A C   1 
ATOM   1149 O O   . TRP A 1 152 ? -14.20850 39.59543 4.81597   1.000 23.80910 ? 147 TRP A O   1 
ATOM   1150 C CB  . TRP A 1 152 ? -15.87878 41.17456 2.75441   1.000 21.91760 ? 147 TRP A CB  1 
ATOM   1151 C CG  . TRP A 1 152 ? -17.28657 41.24212 3.28023   1.000 23.47790 ? 147 TRP A CG  1 
ATOM   1152 C CD1 . TRP A 1 152 ? -18.20883 42.21548 3.02223   1.000 25.10308 ? 147 TRP A CD1 1 
ATOM   1153 C CD2 . TRP A 1 152 ? -17.95884 40.24756 4.05815   1.000 23.80129 ? 147 TRP A CD2 1 
ATOM   1154 N NE1 . TRP A 1 152 ? -19.41221 41.89900 3.62157   1.000 26.34378 ? 147 TRP A NE1 1 
ATOM   1155 C CE2 . TRP A 1 152 ? -19.28044 40.70051 4.26819   1.000 26.31919 ? 147 TRP A CE2 1 
ATOM   1156 C CE3 . TRP A 1 152 ? -17.56699 39.02483 4.61702   1.000 25.87181 ? 147 TRP A CE3 1 
ATOM   1157 C CZ2 . TRP A 1 152 ? -20.20743 39.97814 5.00822   1.000 27.64335 ? 147 TRP A CZ2 1 
ATOM   1158 C CZ3 . TRP A 1 152 ? -18.48934 38.30684 5.35047   1.000 27.56281 ? 147 TRP A CZ3 1 
ATOM   1159 C CH2 . TRP A 1 152 ? -19.79636 38.78909 5.54604   1.000 25.26538 ? 147 TRP A CH2 1 
ATOM   1160 N N   . GLU A 1 153 ? -14.89142 41.33352 6.07641   1.000 23.02651 ? 148 GLU A N   1 
ATOM   1161 C CA  . GLU A 1 153 ? -14.70773 40.59798 7.32148   1.000 23.98713 ? 148 GLU A CA  1 
ATOM   1162 C C   . GLU A 1 153 ? -15.93085 40.73172 8.21273   1.000 23.10818 ? 148 GLU A C   1 
ATOM   1163 O O   . GLU A 1 153 ? -16.48289 41.82611 8.37492   1.000 24.45241 ? 148 GLU A O   1 
ATOM   1164 C CB  . GLU A 1 153 ? -13.45918 41.06720 8.09968   1.000 25.87532 ? 148 GLU A CB  1 
ATOM   1165 C CG  . GLU A 1 153 ? -13.22105 40.27579 9.37619   1.000 27.98239 ? 148 GLU A CG  1 
ATOM   1166 C CD  . GLU A 1 153 ? -11.85285 40.52126 10.00236  1.000 31.90173 ? 148 GLU A CD  1 
ATOM   1167 O OE1 . GLU A 1 153 ? -10.98015 41.11444 9.34863   1.000 34.90600 ? 148 GLU A OE1 1 
ATOM   1168 O OE2 . GLU A 1 153 ? -11.65918 40.12183 11.16224  1.000 42.88968 ? 148 GLU A OE2 1 
ATOM   1169 N N   . SER A 1 154 ? -16.34192 39.60377 8.78985   1.000 24.49140 ? 149 SER A N   1 
ATOM   1170 C CA  . SER A 1 154 ? -17.53766 39.54556 9.61496   1.000 26.85723 ? 149 SER A CA  1 
ATOM   1171 C C   . SER A 1 154 ? -17.31758 38.55905 10.74491  1.000 30.13116 ? 149 SER A C   1 
ATOM   1172 O O   . SER A 1 154 ? -16.77612 37.47146 10.53320  1.000 26.76203 ? 149 SER A O   1 
ATOM   1173 C CB  . SER A 1 154 ? -18.76266 39.11693 8.80402   1.000 30.24997 ? 149 SER A CB  1 
ATOM   1174 O OG  . SER A 1 154 ? -19.91395 39.04159 9.63048   1.000 30.92322 ? 149 SER A OG  1 
ATOM   1175 N N   . ASN A 1 155 ? -17.76161 38.93677 11.94045  1.000 29.07105 ? 150 ASN A N   1 
ATOM   1176 C CA  . ASN A 1 155 ? -17.83603 38.02251 13.06902  1.000 31.00683 ? 150 ASN A CA  1 
ATOM   1177 C C   . ASN A 1 155 ? -19.28820 37.77057 13.46612  1.000 34.61825 ? 150 ASN A C   1 
ATOM   1178 O O   . ASN A 1 155 ? -19.58608 37.52864 14.63694  1.000 32.15810 ? 150 ASN A O   1 
ATOM   1179 C CB  . ASN A 1 155 ? -17.02133 38.56517 14.24638  1.000 35.16343 ? 150 ASN A CB  1 
ATOM   1180 C CG  . ASN A 1 155 ? -17.58863 39.86120 14.80326  1.000 37.39529 ? 150 ASN A CG  1 
ATOM   1181 O OD1 . ASN A 1 155 ? -18.52663 40.43314 14.25020  1.000 40.56627 ? 150 ASN A OD1 1 
ATOM   1182 N ND2 . ASN A 1 155 ? -17.01275 40.33283 15.90693  1.000 46.26963 ? 150 ASN A ND2 1 
ATOM   1183 N N   . ALA A 1 156 ? -20.19989 37.86137 12.49208  1.000 29.77255 ? 151 ALA A N   1 
ATOM   1184 C CA  . ALA A 1 156 ? -21.63887 37.62609 12.62475  1.000 31.62698 ? 151 ALA A CA  1 
ATOM   1185 C C   . ALA A 1 156 ? -22.36976 38.69838 13.42450  1.000 40.38281 ? 151 ALA A C   1 
ATOM   1186 O O   . ALA A 1 156 ? -23.51700 38.48165 13.82950  1.000 44.86804 ? 151 ALA A O   1 
ATOM   1187 C CB  . ALA A 1 156 ? -21.94420 36.25660 13.24032  1.000 32.92098 ? 151 ALA A CB  1 
ATOM   1188 N N   . GLY A 1 157 ? -21.75954 39.84467 13.66275  1.000 40.03290 ? 152 GLY A N   1 
ATOM   1189 C CA  . GLY A 1 157 ? -22.42939 40.91212 14.37256  1.000 41.21522 ? 152 GLY A CA  1 
ATOM   1190 C C   . GLY A 1 157 ? -23.42468 41.63772 13.49406  1.000 42.85681 ? 152 GLY A C   1 
ATOM   1191 O O   . GLY A 1 157 ? -23.87635 41.13761 12.46002  1.000 45.89710 ? 152 GLY A O   1 
ATOM   1192 N N   . GLY A 1 158 ? -23.78066 42.83487 13.92627  1.000 38.79202 ? 153 GLY A N   1 
ATOM   1193 C CA  . GLY A 1 158 ? -24.56156 43.69085 13.07228  1.000 40.23204 ? 153 GLY A CA  1 
ATOM   1194 C C   . GLY A 1 158 ? -23.76234 44.48242 12.07568  1.000 38.91188 ? 153 GLY A C   1 
ATOM   1195 O O   . GLY A 1 158 ? -24.36254 45.16991 11.24581  1.000 40.18973 ? 153 GLY A O   1 
ATOM   1196 N N   . SER A 1 159 ? -22.42681 44.40105 12.12100  1.000 34.93425 ? 154 SER A N   1 
ATOM   1197 C CA  . SER A 1 159 ? -21.56216 45.19373 11.25908  1.000 35.46412 ? 154 SER A CA  1 
ATOM   1198 C C   . SER A 1 159 ? -20.49567 44.32345 10.61090  1.000 31.08137 ? 154 SER A C   1 
ATOM   1199 O O   . SER A 1 159 ? -20.08028 43.30224 11.16157  1.000 32.53674 ? 154 SER A O   1 
ATOM   1200 C CB  . SER A 1 159 ? -20.86910 46.32634 12.04206  1.000 34.91322 ? 154 SER A CB  1 
ATOM   1201 O OG  . SER A 1 159 ? -21.81393 47.30659 12.41200  1.000 48.23004 ? 154 SER A OG  1 
ATOM   1202 N N   . PHE A 1 160 ? -20.05227 44.74832 9.43268   1.000 29.58828 ? 155 PHE A N   1 
ATOM   1203 C CA  . PHE A 1 160 ? -18.92089 44.13190 8.75571   1.000 29.14235 ? 155 PHE A CA  1 
ATOM   1204 C C   . PHE A 1 160 ? -18.01447 45.23439 8.23298   1.000 27.79260 ? 155 PHE A C   1 
ATOM   1205 O O   . PHE A 1 160 ? -18.40809 46.40202 8.14846   1.000 30.63555 ? 155 PHE A O   1 
ATOM   1206 C CB  . PHE A 1 160 ? -19.36542 43.19976 7.60974   1.000 27.68147 ? 155 PHE A CB  1 
ATOM   1207 C CG  . PHE A 1 160 ? -20.12011 43.89154 6.49759   1.000 31.23307 ? 155 PHE A CG  1 
ATOM   1208 C CD1 . PHE A 1 160 ? -19.45186 44.37604 5.38720   1.000 28.30242 ? 155 PHE A CD1 1 
ATOM   1209 C CD2 . PHE A 1 160 ? -21.51038 44.01954 6.55156   1.000 28.55946 ? 155 PHE A CD2 1 
ATOM   1210 C CE1 . PHE A 1 160 ? -20.13643 44.99564 4.35424   1.000 30.64191 ? 155 PHE A CE1 1 
ATOM   1211 C CE2 . PHE A 1 160 ? -22.20776 44.63547 5.53141   1.000 30.54874 ? 155 PHE A CE2 1 
ATOM   1212 C CZ  . PHE A 1 160 ? -21.52667 45.12010 4.41625   1.000 31.78875 ? 155 PHE A CZ  1 
ATOM   1213 N N   . THR A 1 161 ? -16.78685 44.86193 7.86922   1.000 27.78841 ? 156 THR A N   1 
ATOM   1214 C CA  . THR A 1 161 ? -15.84294 45.82391 7.32869   1.000 25.33211 ? 156 THR A CA  1 
ATOM   1215 C C   . THR A 1 161 ? -15.38320 45.38661 5.94786   1.000 27.74321 ? 156 THR A C   1 
ATOM   1216 O O   . THR A 1 161 ? -15.32612 44.19475 5.64454   1.000 26.43579 ? 156 THR A O   1 
ATOM   1217 C CB  . THR A 1 161 ? -14.61733 46.00400 8.23929   1.000 28.23587 ? 156 THR A CB  1 
ATOM   1218 O OG1 . THR A 1 161 ? -13.86374 44.78783 8.27050   1.000 29.52711 ? 156 THR A OG1 1 
ATOM   1219 C CG2 . THR A 1 161 ? -15.05394 46.37006 9.66406   1.000 32.13610 ? 156 THR A CG2 1 
ATOM   1220 N N   . VAL A 1 162 ? -15.06136 46.36530 5.10507   1.000 27.24145 ? 157 VAL A N   1 
ATOM   1221 C CA  . VAL A 1 162 ? -14.41447 46.10499 3.82623   1.000 26.51540 ? 157 VAL A CA  1 
ATOM   1222 C C   . VAL A 1 162 ? -13.15190 46.94833 3.76722   1.000 31.53723 ? 157 VAL A C   1 
ATOM   1223 O O   . VAL A 1 162 ? -13.19787 48.15987 4.01411   1.000 31.27795 ? 157 VAL A O   1 
ATOM   1224 C CB  . VAL A 1 162 ? -15.34246 46.40089 2.63312   1.000 27.23676 ? 157 VAL A CB  1 
ATOM   1225 C CG1 . VAL A 1 162 ? -14.64381 46.08844 1.32650   1.000 26.89098 ? 157 VAL A CG1 1 
ATOM   1226 C CG2 . VAL A 1 162 ? -16.62801 45.57218 2.75430   1.000 28.88126 ? 157 VAL A CG2 1 
ATOM   1227 N N   . THR A 1 163 ? -12.02975 46.30360 3.44924   1.000 26.71523 ? 158 THR A N   1 
ATOM   1228 C CA  . THR A 1 163 ? -10.70470 46.90991 3.49887   1.000 26.87209 ? 158 THR A CA  1 
ATOM   1229 C C   . THR A 1 163 ? -9.94759  46.57629 2.22483   1.000 26.63701 ? 158 THR A C   1 
ATOM   1230 O O   . THR A 1 163 ? -9.94435  45.41874 1.79221   1.000 26.13706 ? 158 THR A O   1 
ATOM   1231 C CB  . THR A 1 163 ? -9.92023  46.39364 4.71221   1.000 29.87537 ? 158 THR A CB  1 
ATOM   1232 O OG1 . THR A 1 163 ? -10.72346 46.53660 5.89125   1.000 32.59087 ? 158 THR A OG1 1 
ATOM   1233 C CG2 . THR A 1 163 ? -8.61134  47.15697 4.88331   1.000 33.89809 ? 158 THR A CG2 1 
ATOM   1234 N N   . LEU A 1 164 ? -9.30474  47.58145 1.63300   1.000 26.92731 ? 159 LEU A N   1 
ATOM   1235 C CA  . LEU A 1 164 ? -8.37887  47.32978 0.54262   1.000 27.39881 ? 159 LEU A CA  1 
ATOM   1236 C C   . LEU A 1 164 ? -7.28462  46.39671 1.03772   1.000 27.81701 ? 159 LEU A C   1 
ATOM   1237 O O   . LEU A 1 164 ? -6.71089  46.61737 2.10723   1.000 27.24223 ? 159 LEU A O   1 
ATOM   1238 C CB  . LEU A 1 164 ? -7.77764  48.64375 0.04717   1.000 30.79697 ? 159 LEU A CB  1 
ATOM   1239 C CG  . LEU A 1 164 ? -6.90175  48.54980 -1.19219  1.000 31.47278 ? 159 LEU A CG  1 
ATOM   1240 C CD1 . LEU A 1 164 ? -7.72410  48.05689 -2.39031  1.000 28.70234 ? 159 LEU A CD1 1 
ATOM   1241 C CD2 . LEU A 1 164 ? -6.27559  49.91105 -1.48431  1.000 33.84138 ? 159 LEU A CD2 1 
ATOM   1242 N N   . ASP A 1 165 ? -7.00615  45.34490 0.26970   1.000 25.99259 ? 160 ASP A N   1 
ATOM   1243 C CA  . ASP A 1 165 ? -6.15675  44.26417 0.75682   1.000 23.85431 ? 160 ASP A CA  1 
ATOM   1244 C C   . ASP A 1 165 ? -4.69054  44.64707 0.59332   1.000 28.78074 ? 160 ASP A C   1 
ATOM   1245 O O   . ASP A 1 165 ? -4.20650  44.82210 -0.53053  1.000 27.26332 ? 160 ASP A O   1 
ATOM   1246 C CB  . ASP A 1 165 ? -6.45947  42.95643 0.02055   1.000 23.71811 ? 160 ASP A CB  1 
ATOM   1247 C CG  . ASP A 1 165 ? -5.71945  41.75245 0.61327   1.000 29.46008 ? 160 ASP A CG  1 
ATOM   1248 O OD1 . ASP A 1 165 ? -4.59630  41.90796 1.16776   1.000 25.35060 ? 160 ASP A OD1 1 
ATOM   1249 O OD2 . ASP A 1 165 ? -6.26166  40.63249 0.52476   1.000 24.50378 ? 160 ASP A OD2 1 
ATOM   1250 N N   . THR A 1 166 ? -3.97686  44.74457 1.71633   1.000 27.85536 ? 161 THR A N   1 
ATOM   1251 C CA  . THR A 1 166 ? -2.54331  44.99595 1.68960   1.000 27.78402 ? 161 THR A CA  1 
ATOM   1252 C C   . THR A 1 166 ? -1.76578  43.94200 2.46517   1.000 32.04313 ? 161 THR A C   1 
ATOM   1253 O O   . THR A 1 166 ? -0.58257  44.15075 2.75742   1.000 31.44840 ? 161 THR A O   1 
ATOM   1254 C CB  . THR A 1 166 ? -2.21561  46.38252 2.25673   1.000 30.13548 ? 161 THR A CB  1 
ATOM   1255 O OG1 . THR A 1 166 ? -2.51129  46.39247 3.65748   1.000 30.69049 ? 161 THR A OG1 1 
ATOM   1256 C CG2 . THR A 1 166 ? -3.03012  47.46171 1.57047   1.000 30.18776 ? 161 THR A CG2 1 
ATOM   1257 N N   . VAL A 1 167 ? -2.39448  42.81541 2.81046   1.000 25.31112 ? 162 VAL A N   1 
ATOM   1258 C CA  . VAL A 1 167 ? -1.76432  41.82512 3.67687   1.000 26.96398 ? 162 VAL A CA  1 
ATOM   1259 C C   . VAL A 1 167 ? -1.76318  40.42337 3.09548   1.000 27.01339 ? 162 VAL A C   1 
ATOM   1260 O O   . VAL A 1 167 ? -0.97168  39.57136 3.54846   1.000 25.93855 ? 162 VAL A O   1 
ATOM   1261 C CB  . VAL A 1 167 ? -2.43653  41.81726 5.06903   1.000 27.76917 ? 162 VAL A CB  1 
ATOM   1262 C CG1 . VAL A 1 167 ? -2.25464  43.18765 5.75160   1.000 29.69634 ? 162 VAL A CG1 1 
ATOM   1263 C CG2 . VAL A 1 167 ? -3.92283  41.42189 4.94801   1.000 28.50196 ? 162 VAL A CG2 1 
ATOM   1264 N N   . ASN A 1 168 ? -2.60794  40.10408 2.12539   1.000 24.38105 ? 163 ASN A N   1 
ATOM   1265 C CA  . ASN A 1 168 ? -2.67483  38.75354 1.59245   1.000 23.72487 ? 163 ASN A CA  1 
ATOM   1266 C C   . ASN A 1 168 ? -2.01679  38.69672 0.22722   1.000 22.79779 ? 163 ASN A C   1 
ATOM   1267 O O   . ASN A 1 168 ? -1.78940  39.72008 -0.41834  1.000 23.76787 ? 163 ASN A O   1 
ATOM   1268 C CB  . ASN A 1 168 ? -4.12789  38.28198 1.49257   1.000 25.60158 ? 163 ASN A CB  1 
ATOM   1269 C CG  . ASN A 1 168 ? -4.81881  38.31728 2.82658   1.000 28.11339 ? 163 ASN A CG  1 
ATOM   1270 O OD1 . ASN A 1 168 ? -4.35950  37.68249 3.77785   1.000 24.84224 ? 163 ASN A OD1 1 
ATOM   1271 N ND2 . ASN A 1 168 ? -5.89263  39.10317 2.92893   1.000 23.58737 ? 163 ASN A ND2 1 
ATOM   1272 N N   . GLU A 1 169 ? -1.71492  37.48221 -0.20895  1.000 21.67868 ? 164 GLU A N   1 
ATOM   1273 C CA  . GLU A 1 169 ? -1.24317  37.30408 -1.57251  1.000 27.88761 ? 164 GLU A CA  1 
ATOM   1274 C C   . GLU A 1 169 ? -2.24513  37.91600 -2.54190  1.000 25.16005 ? 164 GLU A C   1 
ATOM   1275 O O   . GLU A 1 169 ? -3.45176  37.74217 -2.38239  1.000 26.61524 ? 164 GLU A O   1 
ATOM   1276 C CB  . GLU A 1 169 ? -1.06609  35.81706 -1.87090  1.000 30.64828 ? 164 GLU A CB  1 
ATOM   1277 C CG  . GLU A 1 169 ? -0.68522  35.54333 -3.30448  1.000 32.39309 ? 164 GLU A CG  1 
ATOM   1278 C CD  . GLU A 1 169 ? -0.68309  34.05610 -3.63092  1.000 43.90083 ? 164 GLU A CD  1 
ATOM   1279 O OE1 . GLU A 1 169 ? -1.53522  33.30851 -3.08323  1.000 42.48645 ? 164 GLU A OE1 1 
ATOM   1280 O OE2 . GLU A 1 169 ? 0.18174   33.63851 -4.42919  1.000 42.98048 ? 164 GLU A OE2 1 
ATOM   1281 N N   . LYS A 1 170 ? -1.74993  38.68410 -3.51507  1.000 23.01896 ? 165 LYS A N   1 
ATOM   1282 C CA  . LYS A 1 170 ? -2.61797  39.20751 -4.56446  1.000 26.42742 ? 165 LYS A CA  1 
ATOM   1283 C C   . LYS A 1 170 ? -2.87669  38.07390 -5.55052  1.000 28.16015 ? 165 LYS A C   1 
ATOM   1284 O O   . LYS A 1 170 ? -1.98330  37.69472 -6.31634  1.000 27.91628 ? 165 LYS A O   1 
ATOM   1285 C CB  . LYS A 1 170 ? -1.98068  40.41479 -5.25328  1.000 26.95510 ? 165 LYS A CB  1 
ATOM   1286 C CG  . LYS A 1 170 ? -1.79615  41.65405 -4.35898  1.000 25.79619 ? 165 LYS A CG  1 
ATOM   1287 C CD  . LYS A 1 170 ? -3.11427  42.28352 -3.91290  1.000 25.86441 ? 165 LYS A CD  1 
ATOM   1288 C CE  . LYS A 1 170 ? -2.92940  43.76738 -3.57670  1.000 36.52750 ? 165 LYS A CE  1 
ATOM   1289 N NZ  . LYS A 1 170 ? -2.04307  43.99027 -2.37758  1.000 31.94545 ? 165 LYS A NZ  1 
ATOM   1290 N N   . ILE A 1 171 ? -4.08614  37.50155 -5.51422  1.000 23.51453 ? 166 ILE A N   1 
ATOM   1291 C CA  . ILE A 1 171 ? -4.40218  36.37318 -6.38588  1.000 25.11460 ? 166 ILE A CA  1 
ATOM   1292 C C   . ILE A 1 171 ? -4.74393  36.87750 -7.78767  1.000 25.84866 ? 166 ILE A C   1 
ATOM   1293 O O   . ILE A 1 171 ? -5.06233  38.04561 -7.99599  1.000 25.15016 ? 166 ILE A O   1 
ATOM   1294 C CB  . ILE A 1 171 ? -5.54445  35.51841 -5.80439  1.000 25.67959 ? 166 ILE A CB  1 
ATOM   1295 C CG1 . ILE A 1 171 ? -6.83669  36.33333 -5.67404  1.000 24.74899 ? 166 ILE A CG1 1 
ATOM   1296 C CG2 . ILE A 1 171 ? -5.14401  34.93979 -4.45293  1.000 27.55247 ? 166 ILE A CG2 1 
ATOM   1297 C CD1 . ILE A 1 171 ? -8.04539  35.46721 -5.21548  1.000 24.60117 ? 166 ILE A CD1 1 
ATOM   1298 N N   . GLY A 1 172 ? -4.64394  35.98100 -8.76967  1.000 25.16984 ? 167 GLY A N   1 
ATOM   1299 C CA  . GLY A 1 172 ? -4.98065  36.37405 -10.13194 1.000 26.81964 ? 167 GLY A CA  1 
ATOM   1300 C C   . GLY A 1 172 ? -6.44083  36.76359 -10.26122 1.000 24.76345 ? 167 GLY A C   1 
ATOM   1301 O O   . GLY A 1 172 ? -6.77255  37.83799 -10.77585 1.000 22.44650 ? 167 GLY A O   1 
ATOM   1302 N N   . ARG A 1 173 ? -7.32912  35.91393 -9.74731  1.000 21.49106 ? 168 ARG A N   1 
ATOM   1303 C CA  . ARG A 1 173 ? -8.76828  36.12217 -9.83611  1.000 22.54240 ? 168 ARG A CA  1 
ATOM   1304 C C   . ARG A 1 173 ? -9.44948  35.10880 -8.92681  1.000 19.34210 ? 168 ARG A C   1 
ATOM   1305 O O   . ARG A 1 173 ? -8.98459  33.97098 -8.79609  1.000 21.50333 ? 168 ARG A O   1 
ATOM   1306 C CB  . ARG A 1 173 ? -9.26336  35.94831 -11.28556 1.000 20.52756 ? 168 ARG A CB  1 
ATOM   1307 C CG  . ARG A 1 173 ? -10.72341 36.37016 -11.53039 1.000 21.37748 ? 168 ARG A CG  1 
ATOM   1308 C CD  . ARG A 1 173 ? -11.23974 35.79343 -12.87459 1.000 20.74435 ? 168 ARG A CD  1 
ATOM   1309 N NE  . ARG A 1 173 ? -11.20515 34.33080 -12.89889 1.000 24.75831 ? 168 ARG A NE  1 
ATOM   1310 C CZ  . ARG A 1 173 ? -10.38963 33.61316 -13.65657 1.000 21.27558 ? 168 ARG A CZ  1 
ATOM   1311 N NH1 . ARG A 1 173 ? -9.55573  34.18874 -14.51623 1.000 24.02319 ? 168 ARG A NH1 1 
ATOM   1312 N NH2 . ARG A 1 173 ? -10.40187 32.29100 -13.54546 1.000 23.25094 ? 168 ARG A NH2 1 
ATOM   1313 N N   . GLY A 1 174 ? -10.57323 35.51333 -8.33907  1.000 20.81993 ? 169 GLY A N   1 
ATOM   1314 C CA  . GLY A 1 174 ? -11.36632 34.58341 -7.55986  1.000 19.03173 ? 169 GLY A CA  1 
ATOM   1315 C C   . GLY A 1 174 ? -11.57914 35.03408 -6.12645  1.000 19.75733 ? 169 GLY A C   1 
ATOM   1316 O O   . GLY A 1 174 ? -11.50409 36.22490 -5.82173  1.000 20.26194 ? 169 GLY A O   1 
ATOM   1317 N N   . THR A 1 175 ? -11.83600 34.08552 -5.23393  1.000 19.08763 ? 170 THR A N   1 
ATOM   1318 C CA  . THR A 1 175 ? -12.25265 34.40227 -3.87674  1.000 20.37127 ? 170 THR A CA  1 
ATOM   1319 C C   . THR A 1 175 ? -11.63776 33.38931 -2.93466  1.000 21.64247 ? 170 THR A C   1 
ATOM   1320 O O   . THR A 1 175 ? -11.59630 32.19884 -3.24718  1.000 18.44259 ? 170 THR A O   1 
ATOM   1321 C CB  . THR A 1 175 ? -13.79229 34.37554 -3.74822  1.000 24.38690 ? 170 THR A CB  1 
ATOM   1322 O OG1 . THR A 1 175 ? -14.34941 35.39745 -4.58393  1.000 24.18590 ? 170 THR A OG1 1 
ATOM   1323 C CG2 . THR A 1 175 ? -14.22303 34.62915 -2.31031  1.000 24.90626 ? 170 THR A CG2 1 
ATOM   1324 N N   . ILE A 1 176 ? -11.15015 33.86840 -1.79038  1.000 19.58910 ? 171 ILE A N   1 
ATOM   1325 C CA  . ILE A 1 176 ? -10.75739 33.01613 -0.67889  1.000 22.89479 ? 171 ILE A CA  1 
ATOM   1326 C C   . ILE A 1 176 ? -11.74498 33.26020 0.44733   1.000 19.73382 ? 171 ILE A C   1 
ATOM   1327 O O   . ILE A 1 176 ? -11.93733 34.40641 0.87011   1.000 21.51786 ? 171 ILE A O   1 
ATOM   1328 C CB  . ILE A 1 176 ? -9.32911  33.31371 -0.18674  1.000 24.52129 ? 171 ILE A CB  1 
ATOM   1329 C CG1 . ILE A 1 176 ? -8.30579  33.13048 -1.29769  1.000 25.48950 ? 171 ILE A CG1 1 
ATOM   1330 C CG2 . ILE A 1 176 ? -8.96230  32.42685 1.03036   1.000 22.76697 ? 171 ILE A CG2 1 
ATOM   1331 C CD1 . ILE A 1 176 ? -6.94361  33.72849 -0.93322  1.000 31.50959 ? 171 ILE A CD1 1 
ATOM   1332 N N   . LEU A 1 177 ? -12.35191 32.19524 0.94039   1.000 21.68615 ? 172 LEU A N   1 
ATOM   1333 C CA  . LEU A 1 177 ? -13.08092 32.24204 2.19936   1.000 22.18843 ? 172 LEU A CA  1 
ATOM   1334 C C   . LEU A 1 177 ? -12.12932 31.73849 3.27911   1.000 20.63051 ? 172 LEU A C   1 
ATOM   1335 O O   . LEU A 1 177 ? -11.80367 30.54953 3.31595   1.000 23.02555 ? 172 LEU A O   1 
ATOM   1336 C CB  . LEU A 1 177 ? -14.35231 31.39726 2.14282   1.000 20.78464 ? 172 LEU A CB  1 
ATOM   1337 C CG  . LEU A 1 177 ? -15.65241 32.14856 1.83942   1.000 24.91054 ? 172 LEU A CG  1 
ATOM   1338 C CD1 . LEU A 1 177 ? -15.56504 32.81872 0.50135   1.000 20.48576 ? 172 LEU A CD1 1 
ATOM   1339 C CD2 . LEU A 1 177 ? -16.84584 31.20403 1.88852   1.000 24.47242 ? 172 LEU A CD2 1 
ATOM   1340 N N   . ARG A 1 178 ? -11.67145 32.64635 4.14158   1.000 23.47242 ? 173 ARG A N   1 
ATOM   1341 C CA  . ARG A 1 178 ? -10.77748 32.30545 5.24267   1.000 21.88083 ? 173 ARG A CA  1 
ATOM   1342 C C   . ARG A 1 178 ? -11.62469 32.14543 6.49917   1.000 20.04784 ? 173 ARG A C   1 
ATOM   1343 O O   . ARG A 1 178 ? -12.11257 33.13787 7.05426   1.000 22.33116 ? 173 ARG A O   1 
ATOM   1344 C CB  . ARG A 1 178 ? -9.71323  33.38477 5.42864   1.000 23.05438 ? 173 ARG A CB  1 
ATOM   1345 C CG  . ARG A 1 178 ? -8.73654  33.10430 6.58013   1.000 24.03942 ? 173 ARG A CG  1 
ATOM   1346 C CD  . ARG A 1 178 ? -7.63202  34.14659 6.64765   1.000 22.18351 ? 173 ARG A CD  1 
ATOM   1347 N NE  . ARG A 1 178 ? -6.71386  34.03578 5.52146   1.000 23.16480 ? 173 ARG A NE  1 
ATOM   1348 C CZ  . ARG A 1 178 ? -5.96872  35.03068 5.05469   1.000 27.13048 ? 173 ARG A CZ  1 
ATOM   1349 N NH1 . ARG A 1 178 ? -6.04150  36.25158 5.56852   1.000 27.48340 ? 173 ARG A NH1 1 
ATOM   1350 N NH2 . ARG A 1 178 ? -5.12192  34.79393 4.05101   1.000 27.68430 ? 173 ARG A NH2 1 
ATOM   1351 N N   . LEU A 1 179 ? -11.78870 30.90581 6.95222   1.000 20.84445 ? 174 LEU A N   1 
ATOM   1352 C CA  . LEU A 1 179 ? -12.63320 30.59843 8.10226   1.000 23.21080 ? 174 LEU A CA  1 
ATOM   1353 C C   . LEU A 1 179 ? -11.76585 30.52617 9.35189   1.000 25.43054 ? 174 LEU A C   1 
ATOM   1354 O O   . LEU A 1 179 ? -10.85714 29.69270 9.42818   1.000 24.15946 ? 174 LEU A O   1 
ATOM   1355 C CB  . LEU A 1 179 ? -13.36851 29.26784 7.93705   1.000 19.45785 ? 174 LEU A CB  1 
ATOM   1356 C CG  . LEU A 1 179 ? -14.17615 29.03803 6.65414   1.000 26.35259 ? 174 LEU A CG  1 
ATOM   1357 C CD1 . LEU A 1 179 ? -15.03026 27.76662 6.76969   1.000 25.02307 ? 174 LEU A CD1 1 
ATOM   1358 C CD2 . LEU A 1 179 ? -15.01218 30.22657 6.31441   1.000 22.08775 ? 174 LEU A CD2 1 
ATOM   1359 N N   . PHE A 1 180 ? -12.08338 31.35126 10.34258  1.000 25.44976 ? 175 PHE A N   1 
ATOM   1360 C CA  . PHE A 1 180 ? -11.42061 31.27163 11.64523  1.000 28.18731 ? 175 PHE A CA  1 
ATOM   1361 C C   . PHE A 1 180 ? -12.23718 30.30749 12.48772  1.000 26.21757 ? 175 PHE A C   1 
ATOM   1362 O O   . PHE A 1 180 ? -13.33106 30.64124 12.94648  1.000 26.32036 ? 175 PHE A O   1 
ATOM   1363 C CB  . PHE A 1 180 ? -11.29395 32.65556 12.26217  1.000 26.18176 ? 175 PHE A CB  1 
ATOM   1364 C CG  . PHE A 1 180 ? -10.42877 33.57578 11.45021  1.000 28.34581 ? 175 PHE A CG  1 
ATOM   1365 C CD1 . PHE A 1 180 ? -10.94556 34.25284 10.35993  1.000 27.35718 ? 175 PHE A CD1 1 
ATOM   1366 C CD2 . PHE A 1 180 ? -9.08269  33.72793 11.75136  1.000 31.83659 ? 175 PHE A CD2 1 
ATOM   1367 C CE1 . PHE A 1 180 ? -10.13959 35.10021 9.59830   1.000 30.48032 ? 175 PHE A CE1 1 
ATOM   1368 C CE2 . PHE A 1 180 ? -8.27215  34.56289 10.98689  1.000 31.43997 ? 175 PHE A CE2 1 
ATOM   1369 C CZ  . PHE A 1 180 ? -8.80181  35.24631 9.91478   1.000 30.00879 ? 175 PHE A CZ  1 
ATOM   1370 N N   . MET A 1 181 ? -11.70849 29.09713 12.65496  1.000 26.56680 ? 176 MET A N   1 
ATOM   1371 C CA  . MET A 1 181 ? -12.49760 27.96462 13.11951  1.000 28.65628 ? 176 MET A CA  1 
ATOM   1372 C C   . MET A 1 181 ? -12.83068 28.07065 14.60269  1.000 33.65741 ? 176 MET A C   1 
ATOM   1373 O O   . MET A 1 181 ? -12.01353 28.52601 15.41102  1.000 28.94899 ? 176 MET A O   1 
ATOM   1374 C CB  . MET A 1 181 ? -11.74516 26.65977 12.86325  1.000 25.73103 ? 176 MET A CB  1 
ATOM   1375 C CG  . MET A 1 181 ? -11.43032 26.39027 11.37732  1.000 30.41137 ? 176 MET A CG  1 
ATOM   1376 S SD  . MET A 1 181 ? -12.92075 26.33456 10.35841  1.000 28.45712 ? 176 MET A SD  1 
ATOM   1377 C CE  . MET A 1 181 ? -13.58826 24.73982 10.82080  1.000 26.66922 ? 176 MET A CE  1 
ATOM   1378 N N   . LYS A 1 182 ? -14.04118 27.63602 14.95141  1.000 30.48672 ? 177 LYS A N   1 
ATOM   1379 C CA  . LYS A 1 182 ? -14.43308 27.49988 16.35023  1.000 33.51860 ? 177 LYS A CA  1 
ATOM   1380 C C   . LYS A 1 182 ? -13.54327 26.47190 17.03906  1.000 31.01536 ? 177 LYS A C   1 
ATOM   1381 O O   . LYS A 1 182 ? -13.10571 25.49829 16.42593  1.000 33.40900 ? 177 LYS A O   1 
ATOM   1382 C CB  . LYS A 1 182 ? -15.90406 27.06817 16.45476  1.000 32.05037 ? 177 LYS A CB  1 
ATOM   1383 C CG  . LYS A 1 182 ? -16.90337 28.15016 16.06006  1.000 26.94000 ? 177 LYS A CG  1 
ATOM   1384 C CD  . LYS A 1 182 ? -18.34150 27.60212 16.03113  1.000 27.88007 ? 177 LYS A CD  1 
ATOM   1385 C CE  . LYS A 1 182 ? -19.35473 28.71751 15.79409  1.000 33.33673 ? 177 LYS A CE  1 
ATOM   1386 N NZ  . LYS A 1 182 ? -20.76610 28.20236 15.71121  1.000 29.27686 ? 177 LYS A NZ  1 
ATOM   1387 N N   . GLU A 1 183 ? -13.27466 26.69735 18.33244  1.000 37.27515 ? 178 GLU A N   1 
ATOM   1388 C CA  . GLU A 1 183 ? -12.33879 25.83936 19.06162  1.000 40.09539 ? 178 GLU A CA  1 
ATOM   1389 C C   . GLU A 1 183 ? -12.76496 24.38059 19.05192  1.000 38.04457 ? 178 GLU A C   1 
ATOM   1390 O O   . GLU A 1 183 ? -11.91494 23.48334 19.04065  1.000 42.85026 ? 178 GLU A O   1 
ATOM   1391 C CB  . GLU A 1 183 ? -12.19208 26.31291 20.50906  1.000 39.52397 ? 178 GLU A CB  1 
ATOM   1392 C CG  . GLU A 1 183 ? -11.03557 27.24766 20.73629  1.000 47.48757 ? 178 GLU A CG  1 
ATOM   1393 C CD  . GLU A 1 183 ? -9.71052  26.66108 20.27652  1.000 51.61362 ? 178 GLU A CD  1 
ATOM   1394 O OE1 . GLU A 1 183 ? -9.52337  25.42150 20.36493  1.000 54.17820 ? 178 GLU A OE1 1 
ATOM   1395 O OE2 . GLU A 1 183 ? -8.85358  27.44976 19.82658  1.000 52.22365 ? 178 GLU A OE2 1 
ATOM   1396 N N   . ASP A 1 184 ? -14.06342 24.12188 19.05469  1.000 38.28927 ? 179 ASP A N   1 
ATOM   1397 C CA  . ASP A 1 184 ? -14.58382 22.76379 19.06422  1.000 40.60570 ? 179 ASP A CA  1 
ATOM   1398 C C   . ASP A 1 184 ? -14.73130 22.16513 17.66846  1.000 40.37832 ? 179 ASP A C   1 
ATOM   1399 O O   . ASP A 1 184 ? -15.18162 21.02448 17.54808  1.000 37.60093 ? 179 ASP A O   1 
ATOM   1400 C CB  . ASP A 1 184 ? -15.93678 22.74201 19.77698  1.000 41.91454 ? 179 ASP A CB  1 
ATOM   1401 C CG  . ASP A 1 184 ? -16.86083 23.85470 19.29768  1.000 47.33940 ? 179 ASP A CG  1 
ATOM   1402 O OD1 . ASP A 1 184 ? -16.56884 25.04850 19.56768  1.000 49.11739 ? 179 ASP A OD1 1 
ATOM   1403 O OD2 . ASP A 1 184 ? -17.87148 23.53724 18.63378  1.000 52.26568 ? 179 ASP A OD2 1 
ATOM   1404 N N   . GLN A 1 185 ? -14.37046 22.89797 16.61038  1.000 37.84627 ? 180 GLN A N   1 
ATOM   1405 C CA  . GLN A 1 185 ? -14.58085 22.44054 15.24087  1.000 34.30973 ? 180 GLN A CA  1 
ATOM   1406 C C   . GLN A 1 185 ? -13.26551 22.29275 14.48270  1.000 36.61109 ? 180 GLN A C   1 
ATOM   1407 O O   . GLN A 1 185 ? -13.23530 22.41050 13.25736  1.000 32.16896 ? 180 GLN A O   1 
ATOM   1408 C CB  . GLN A 1 185 ? -15.51739 23.39676 14.49311  1.000 32.90814 ? 180 GLN A CB  1 
ATOM   1409 C CG  . GLN A 1 185 ? -16.88382 23.57459 15.15679  1.000 35.13750 ? 180 GLN A CG  1 
ATOM   1410 C CD  . GLN A 1 185 ? -17.66575 22.27193 15.21913  1.000 37.73283 ? 180 GLN A CD  1 
ATOM   1411 O OE1 . GLN A 1 185 ? -17.53587 21.41117 14.34320  1.000 31.36272 ? 180 GLN A OE1 1 
ATOM   1412 N NE2 . GLN A 1 185 ? -18.46693 22.11130 16.27306  1.000 36.92018 ? 180 GLN A NE2 1 
ATOM   1413 N N   . LEU A 1 186 ? -12.16647 22.03169 15.18681  1.000 34.54649 ? 181 LEU A N   1 
ATOM   1414 C CA  . LEU A 1 186 ? -10.87378 21.95195 14.51498  1.000 31.52159 ? 181 LEU A CA  1 
ATOM   1415 C C   . LEU A 1 186 ? -10.68424 20.63911 13.77764  1.000 32.98165 ? 181 LEU A C   1 
ATOM   1416 O O   . LEU A 1 186 ? -9.66532  20.46374 13.09566  1.000 32.24572 ? 181 LEU A O   1 
ATOM   1417 C CB  . LEU A 1 186 ? -9.73820  22.16459 15.51377  1.000 35.58720 ? 181 LEU A CB  1 
ATOM   1418 C CG  . LEU A 1 186 ? -9.79285  23.53662 16.18179  1.000 36.66882 ? 181 LEU A CG  1 
ATOM   1419 C CD1 . LEU A 1 186 ? -8.73368  23.66818 17.27213  1.000 42.36361 ? 181 LEU A CD1 1 
ATOM   1420 C CD2 . LEU A 1 186 ? -9.61833  24.62460 15.13848  1.000 33.42405 ? 181 LEU A CD2 1 
ATOM   1421 N N   . GLU A 1 187 ? -11.65123 19.72668 13.87022  1.000 31.97294 ? 182 GLU A N   1 
ATOM   1422 C CA  . GLU A 1 187 ? -11.58197 18.50450 13.08287  1.000 33.09170 ? 182 GLU A CA  1 
ATOM   1423 C C   . GLU A 1 187 ? -11.56269 18.79467 11.58549  1.000 31.70514 ? 182 GLU A C   1 
ATOM   1424 O O   . GLU A 1 187 ? -10.99369 18.01627 10.81255  1.000 34.43867 ? 182 GLU A O   1 
ATOM   1425 C CB  . GLU A 1 187 ? -12.75834 17.59902 13.42831  1.000 34.56779 ? 182 GLU A CB  1 
ATOM   1426 C CG  . GLU A 1 187 ? -14.08934 18.09258 12.89196  1.000 34.98368 ? 182 GLU A CG  1 
ATOM   1427 C CD  . GLU A 1 187 ? -15.26879 17.40562 13.54341  1.000 38.44678 ? 182 GLU A CD  1 
ATOM   1428 O OE1 . GLU A 1 187 ? -15.45890 17.60719 14.76596  1.000 39.93930 ? 182 GLU A OE1 1 
ATOM   1429 O OE2 . GLU A 1 187 ? -16.00118 16.67910 12.83582  1.000 33.31521 ? 182 GLU A OE2 1 
ATOM   1430 N N   . TYR A 1 188 ? -12.16809 19.90073 11.15223  1.000 29.92443 ? 183 TYR A N   1 
ATOM   1431 C CA  . TYR A 1 188 ? -12.19370 20.22457 9.73059   1.000 30.14705 ? 183 TYR A CA  1 
ATOM   1432 C C   . TYR A 1 188 ? -10.88177 20.81183 9.24640   1.000 30.04418 ? 183 TYR A C   1 
ATOM   1433 O O   . TYR A 1 188 ? -10.80067 21.23969 8.09143   1.000 29.06935 ? 183 TYR A O   1 
ATOM   1434 C CB  . TYR A 1 188 ? -13.36154 21.17664 9.41310   1.000 29.09825 ? 183 TYR A CB  1 
ATOM   1435 C CG  . TYR A 1 188 ? -14.66321 20.53780 9.79443   1.000 30.57503 ? 183 TYR A CG  1 
ATOM   1436 C CD1 . TYR A 1 188 ? -15.17448 19.47111 9.06248   1.000 27.60517 ? 183 TYR A CD1 1 
ATOM   1437 C CD2 . TYR A 1 188 ? -15.35131 20.94994 10.92802  1.000 32.65296 ? 183 TYR A CD2 1 
ATOM   1438 C CE1 . TYR A 1 188 ? -16.35847 18.85004 9.43979   1.000 32.57259 ? 183 TYR A CE1 1 
ATOM   1439 C CE2 . TYR A 1 188 ? -16.52324 20.33827 11.30810  1.000 30.72907 ? 183 TYR A CE2 1 
ATOM   1440 C CZ  . TYR A 1 188 ? -17.02316 19.29255 10.56654  1.000 30.07041 ? 183 TYR A CZ  1 
ATOM   1441 O OH  . TYR A 1 188 ? -18.20308 18.68694 10.96054  1.000 35.17275 ? 183 TYR A OH  1 
ATOM   1442 N N   . LEU A 1 189 ? -9.85844  20.85340 10.09520  1.000 28.74483 ? 184 LEU A N   1 
ATOM   1443 C CA  . LEU A 1 189 ? -8.51588  21.18136 9.64612   1.000 29.79924 ? 184 LEU A CA  1 
ATOM   1444 C C   . LEU A 1 189 ? -7.68564  19.94150 9.34217   1.000 32.46474 ? 184 LEU A C   1 
ATOM   1445 O O   . LEU A 1 189 ? -6.51375  20.07023 8.97797   1.000 33.55431 ? 184 LEU A O   1 
ATOM   1446 C CB  . LEU A 1 189 ? -7.80648  22.05135 10.69310  1.000 31.03332 ? 184 LEU A CB  1 
ATOM   1447 C CG  . LEU A 1 189 ? -8.47200  23.38818 11.01601  1.000 32.25681 ? 184 LEU A CG  1 
ATOM   1448 C CD1 . LEU A 1 189 ? -7.56537  24.22810 11.88174  1.000 34.43536 ? 184 LEU A CD1 1 
ATOM   1449 C CD2 . LEU A 1 189 ? -8.83737  24.13559 9.73767   1.000 29.40125 ? 184 LEU A CD2 1 
ATOM   1450 N N   . GLU A 1 190 ? -8.26650  18.75440 9.46466   1.000 30.52833 ? 185 GLU A N   1 
ATOM   1451 C CA  . GLU A 1 190 ? -7.54616  17.49684 9.31599   1.000 33.54112 ? 185 GLU A CA  1 
ATOM   1452 C C   . GLU A 1 190 ? -7.83789  16.88010 7.95342   1.000 33.95237 ? 185 GLU A C   1 
ATOM   1453 O O   . GLU A 1 190 ? -8.99540  16.82297 7.52502   1.000 30.89521 ? 185 GLU A O   1 
ATOM   1454 C CB  . GLU A 1 190 ? -7.93898  16.51992 10.43031  1.000 32.35410 ? 185 GLU A CB  1 
ATOM   1455 C CG  . GLU A 1 190 ? -7.77333  17.09640 11.82741  1.000 38.51555 ? 185 GLU A CG  1 
ATOM   1456 C CD  . GLU A 1 190 ? -8.34674  16.20102 12.92745  1.000 44.73446 ? 185 GLU A CD  1 
ATOM   1457 O OE1 . GLU A 1 190 ? -9.01483  15.19195 12.60806  1.000 45.56575 ? 185 GLU A OE1 1 
ATOM   1458 O OE2 . GLU A 1 190 ? -8.13520  16.52292 14.11899  1.000 47.69533 ? 185 GLU A OE2 1 
ATOM   1459 N N   . GLU A 1 191 ? -6.77951  16.38909 7.29463   1.000 32.54286 ? 186 GLU A N   1 
ATOM   1460 C CA  . GLU A 1 191 ? -6.89826  15.85994 5.93344   1.000 30.81363 ? 186 GLU A CA  1 
ATOM   1461 C C   . GLU A 1 191 ? -7.93173  14.73957 5.84165   1.000 32.60043 ? 186 GLU A C   1 
ATOM   1462 O O   . GLU A 1 191 ? -8.73750  14.69582 4.90571   1.000 31.34183 ? 186 GLU A O   1 
ATOM   1463 C CB  . GLU A 1 191 ? -5.53393  15.36177 5.45085   1.000 30.84444 ? 186 GLU A CB  1 
ATOM   1464 C CG  . GLU A 1 191 ? -5.60891  14.43835 4.23973   1.000 35.56092 ? 186 GLU A CG  1 
ATOM   1465 C CD  . GLU A 1 191 ? -4.23705  14.08989 3.67308   1.000 36.64146 ? 186 GLU A CD  1 
ATOM   1466 O OE1 . GLU A 1 191 ? -3.22680  14.45559 4.30598   1.000 40.30692 ? 186 GLU A OE1 1 
ATOM   1467 O OE2 . GLU A 1 191 ? -4.17383  13.46144 2.59534   1.000 36.77937 ? 186 GLU A OE2 1 
ATOM   1468 N N   . LYS A 1 192 ? -7.89673  13.79587 6.78598   1.000 32.69543 ? 187 LYS A N   1 
ATOM   1469 C CA  . LYS A 1 192 ? -8.81529  12.65977 6.73038   1.000 35.20585 ? 187 LYS A CA  1 
ATOM   1470 C C   . LYS A 1 192 ? -10.27137 13.10346 6.84199   1.000 31.57284 ? 187 LYS A C   1 
ATOM   1471 O O   . LYS A 1 192 ? -11.12907 12.62569 6.09239   1.000 30.94919 ? 187 LYS A O   1 
ATOM   1472 C CB  . LYS A 1 192 ? -8.47507  11.66189 7.84218   1.000 38.23429 ? 187 LYS A CB  1 
ATOM   1473 C CG  . LYS A 1 192 ? -9.20875  10.33823 7.72935   1.000 45.07151 ? 187 LYS A CG  1 
ATOM   1474 C CD  . LYS A 1 192 ? -8.82831  9.37850  8.85734   1.000 53.91880 ? 187 LYS A CD  1 
ATOM   1475 C CE  . LYS A 1 192 ? -9.32488  9.87664  10.21070  1.000 52.04249 ? 187 LYS A CE  1 
ATOM   1476 N NZ  . LYS A 1 192 ? -9.46593  8.76230  11.19795  1.000 59.20180 ? 187 LYS A NZ  1 
ATOM   1477 N N   . ARG A 1 193 ? -10.56714 14.01570 7.77429   1.000 30.46255 ? 188 ARG A N   1 
ATOM   1478 C CA  . ARG A 1 193 ? -11.93662 14.49103 7.95964   1.000 31.49491 ? 188 ARG A CA  1 
ATOM   1479 C C   . ARG A 1 193 ? -12.41851 15.27950 6.74498   1.000 32.93870 ? 188 ARG A C   1 
ATOM   1480 O O   . ARG A 1 193 ? -13.54170 15.06726 6.26391   1.000 30.60162 ? 188 ARG A O   1 
ATOM   1481 C CB  . ARG A 1 193 ? -12.02012 15.33719 9.23275   1.000 31.01646 ? 188 ARG A CB  1 
ATOM   1482 C CG  . ARG A 1 193 ? -13.40765 15.90930 9.54656   1.000 33.01369 ? 188 ARG A CG  1 
ATOM   1483 C CD  . ARG A 1 193 ? -14.40843 14.84053 9.98150   1.000 35.82288 ? 188 ARG A CD  1 
ATOM   1484 N NE  . ARG A 1 193 ? -15.70237 15.41895 10.34564  1.000 34.55966 ? 188 ARG A NE  1 
ATOM   1485 C CZ  . ARG A 1 193 ? -16.87520 14.99160 9.89441   1.000 37.16162 ? 188 ARG A CZ  1 
ATOM   1486 N NH1 . ARG A 1 193 ? -16.96560 13.96160 9.06511   1.000 31.77736 ? 188 ARG A NH1 1 
ATOM   1487 N NH2 . ARG A 1 193 ? -17.98811 15.60517 10.29645  1.000 35.98392 ? 188 ARG A NH2 1 
ATOM   1488 N N   . ILE A 1 194 ? -11.57003 16.16977 6.21909   1.000 31.88608 ? 189 ILE A N   1 
ATOM   1489 C CA  . ILE A 1 194 ? -11.94783 16.96984 5.05396   1.000 28.77699 ? 189 ILE A CA  1 
ATOM   1490 C C   . ILE A 1 194 ? -12.29353 16.05987 3.88945   1.000 29.41611 ? 189 ILE A C   1 
ATOM   1491 O O   . ILE A 1 194 ? -13.30476 16.24649 3.20024   1.000 27.03387 ? 189 ILE A O   1 
ATOM   1492 C CB  . ILE A 1 194 ? -10.81387 17.93968 4.67550   1.000 29.60913 ? 189 ILE A CB  1 
ATOM   1493 C CG1 . ILE A 1 194 ? -10.57342 18.97723 5.77236   1.000 27.22758 ? 189 ILE A CG1 1 
ATOM   1494 C CG2 . ILE A 1 194 ? -11.12695 18.62562 3.33920   1.000 28.26723 ? 189 ILE A CG2 1 
ATOM   1495 C CD1 . ILE A 1 194 ? -9.31728  19.80955 5.52912   1.000 30.74740 ? 189 ILE A CD1 1 
ATOM   1496 N N   . LYS A 1 195 ? -11.45486 15.05069 3.65492   1.000 29.20980 ? 190 LYS A N   1 
ATOM   1497 C CA  . LYS A 1 195 ? -11.72026 14.11055 2.57434   1.000 29.73487 ? 190 LYS A CA  1 
ATOM   1498 C C   . LYS A 1 195 ? -13.04131 13.37738 2.78114   1.000 30.68601 ? 190 LYS A C   1 
ATOM   1499 O O   . LYS A 1 195 ? -13.82343 13.23058 1.83655   1.000 31.20742 ? 190 LYS A O   1 
ATOM   1500 C CB  . LYS A 1 195 ? -10.56101 13.11545 2.43955   1.000 34.59848 ? 190 LYS A CB  1 
ATOM   1501 C CG  . LYS A 1 195 ? -9.34005  13.71293 1.77688   1.000 33.22138 ? 190 LYS A CG  1 
ATOM   1502 C CD  . LYS A 1 195 ? -8.51347  12.64642 1.06492   1.000 44.15515 ? 190 LYS A CD  1 
ATOM   1503 C CE  . LYS A 1 195 ? -7.52336  11.96657 1.99074   1.000 46.97830 ? 190 LYS A CE  1 
ATOM   1504 N NZ  . LYS A 1 195 ? -6.60618  11.06613 1.21767   1.000 56.16178 ? 190 LYS A NZ  1 
ATOM   1505 N N   . GLU A 1 196 ? -13.30318 12.89082 4.00342   1.000 29.53067 ? 191 GLU A N   1 
ATOM   1506 C CA  . GLU A 1 196 ? -14.56219 12.18171 4.25055   1.000 30.66062 ? 191 GLU A CA  1 
ATOM   1507 C C   . GLU A 1 196 ? -15.75107 13.04140 3.85809   1.000 31.80831 ? 191 GLU A C   1 
ATOM   1508 O O   . GLU A 1 196 ? -16.67121 12.58452 3.16959   1.000 32.36780 ? 191 GLU A O   1 
ATOM   1509 C CB  . GLU A 1 196 ? -14.72827 11.80857 5.72608   1.000 34.02254 ? 191 GLU A CB  1 
ATOM   1510 C CG  . GLU A 1 196 ? -13.67212 10.99654 6.39770   1.000 45.25910 ? 191 GLU A CG  1 
ATOM   1511 C CD  . GLU A 1 196 ? -13.90226 10.98996 7.91046   1.000 50.74738 ? 191 GLU A CD  1 
ATOM   1512 O OE1 . GLU A 1 196 ? -15.00492 11.42692 8.33958   1.000 46.44697 ? 191 GLU A OE1 1 
ATOM   1513 O OE2 . GLU A 1 196 ? -12.99073 10.57360 8.66483   1.000 54.79510 ? 191 GLU A OE2 1 
ATOM   1514 N N   . VAL A 1 197 ? -15.75316 14.29196 4.31935   1.000 32.66681 ? 192 VAL A N   1 
ATOM   1515 C CA  . VAL A 1 197 ? -16.89092 15.17829 4.09947   1.000 30.61028 ? 192 VAL A CA  1 
ATOM   1516 C C   . VAL A 1 197 ? -17.02213 15.52561 2.62049   1.000 27.35016 ? 192 VAL A C   1 
ATOM   1517 O O   . VAL A 1 197 ? -18.10657 15.42068 2.03650   1.000 27.33369 ? 192 VAL A O   1 
ATOM   1518 C CB  . VAL A 1 197 ? -16.74990 16.43179 4.98017   1.000 28.10391 ? 192 VAL A CB  1 
ATOM   1519 C CG1 . VAL A 1 197 ? -17.86385 17.43012 4.68530   1.000 28.21765 ? 192 VAL A CG1 1 
ATOM   1520 C CG2 . VAL A 1 197 ? -16.75657 16.04320 6.45146   1.000 28.56262 ? 192 VAL A CG2 1 
ATOM   1521 N N   . VAL A 1 198 ? -15.91608 15.91714 1.97796   1.000 28.70224 ? 193 VAL A N   1 
ATOM   1522 C CA  . VAL A 1 198 ? -16.00371 16.35369 0.58212   1.000 26.49909 ? 193 VAL A CA  1 
ATOM   1523 C C   . VAL A 1 198 ? -16.47438 15.21446 -0.31550  1.000 30.29368 ? 193 VAL A C   1 
ATOM   1524 O O   . VAL A 1 198 ? -17.25258 15.42713 -1.25591  1.000 29.54316 ? 193 VAL A O   1 
ATOM   1525 C CB  . VAL A 1 198 ? -14.65686 16.93821 0.10441   1.000 28.94129 ? 193 VAL A CB  1 
ATOM   1526 C CG1 . VAL A 1 198 ? -14.67038 17.15905 -1.38872  1.000 30.71745 ? 193 VAL A CG1 1 
ATOM   1527 C CG2 . VAL A 1 198 ? -14.38122 18.25428 0.80261   1.000 30.03639 ? 193 VAL A CG2 1 
ATOM   1528 N N   . LYS A 1 199 ? -16.02896 13.98247 -0.03990  1.000 27.78506 ? 194 LYS A N   1 
ATOM   1529 C CA  . LYS A 1 199 ? -16.40826 12.86764 -0.90860  1.000 31.08229 ? 194 LYS A CA  1 
ATOM   1530 C C   . LYS A 1 199 ? -17.89385 12.53597 -0.82573  1.000 32.96754 ? 194 LYS A C   1 
ATOM   1531 O O   . LYS A 1 199 ? -18.41264 11.83807 -1.70557  1.000 30.63328 ? 194 LYS A O   1 
ATOM   1532 C CB  . LYS A 1 199 ? -15.58857 11.61946 -0.57098  1.000 32.81965 ? 194 LYS A CB  1 
ATOM   1533 C CG  . LYS A 1 199 ? -14.11133 11.72983 -0.91576  1.000 38.30039 ? 194 LYS A CG  1 
ATOM   1534 C CD  . LYS A 1 199 ? -13.37061 10.45898 -0.50557  1.000 43.98054 ? 194 LYS A CD  1 
ATOM   1535 C CE  . LYS A 1 199 ? -11.88827 10.53936 -0.83454  1.000 45.91665 ? 194 LYS A CE  1 
ATOM   1536 N NZ  . LYS A 1 199 ? -11.13748 9.36716  -0.28162  1.000 49.32918 ? 194 LYS A NZ  1 
ATOM   1537 N N   . LYS A 1 200 ? -18.59392 13.02660 0.19626   1.000 27.66020 ? 195 LYS A N   1 
ATOM   1538 C CA  . LYS A 1 200 ? -20.02905 12.77654 0.27039   1.000 31.71837 ? 195 LYS A CA  1 
ATOM   1539 C C   . LYS A 1 200 ? -20.79465 13.51232 -0.82167  1.000 32.47960 ? 195 LYS A C   1 
ATOM   1540 O O   . LYS A 1 200 ? -21.89400 13.08347 -1.18419  1.000 32.61468 ? 195 LYS A O   1 
ATOM   1541 C CB  . LYS A 1 200 ? -20.56963 13.18096 1.64016   1.000 33.88533 ? 195 LYS A CB  1 
ATOM   1542 C CG  . LYS A 1 200 ? -20.04279 12.33702 2.79042   1.000 32.38444 ? 195 LYS A CG  1 
ATOM   1543 C CD  . LYS A 1 200 ? -20.69994 12.73166 4.09433   1.000 34.30475 ? 195 LYS A CD  1 
ATOM   1544 C CE  . LYS A 1 200 ? -20.08528 11.97261 5.26425   1.000 36.82753 ? 195 LYS A CE  1 
ATOM   1545 N NZ  . LYS A 1 200 ? -20.71560 12.37332 6.54966   1.000 37.02145 ? 195 LYS A NZ  1 
ATOM   1546 N N   . HIS A 1 201 ? -20.25789 14.63737 -1.33640  1.000 34.47306 ? 196 HIS A N   1 
ATOM   1547 C CA  . HIS A 1 201 ? -20.97667 15.41804 -2.34298  1.000 33.72639 ? 196 HIS A CA  1 
ATOM   1548 C C   . HIS A 1 201 ? -20.07996 15.97428 -3.44767  1.000 36.32488 ? 196 HIS A C   1 
ATOM   1549 O O   . HIS A 1 201 ? -20.45347 16.95835 -4.09686  1.000 37.21037 ? 196 HIS A O   1 
ATOM   1550 C CB  . HIS A 1 201 ? -21.73238 16.56487 -1.68574  1.000 30.72980 ? 196 HIS A CB  1 
ATOM   1551 C CG  . HIS A 1 201 ? -22.61539 16.12444 -0.55957  1.000 37.55090 ? 196 HIS A CG  1 
ATOM   1552 N ND1 . HIS A 1 201 ? -23.83118 15.50308 -0.76451  1.000 38.93403 ? 196 HIS A ND1 1 
ATOM   1553 C CD2 . HIS A 1 201 ? -22.44974 16.19470 0.78398   1.000 36.54319 ? 196 HIS A CD2 1 
ATOM   1554 C CE1 . HIS A 1 201 ? -24.37951 15.21816 0.40435   1.000 36.42449 ? 196 HIS A CE1 1 
ATOM   1555 N NE2 . HIS A 1 201 ? -23.56277 15.62744 1.36001   1.000 38.38495 ? 196 HIS A NE2 1 
ATOM   1556 N N   . SER A 1 202 ? -18.92628 15.36320 -3.69790  1.000 35.64111 ? 197 SER A N   1 
ATOM   1557 C CA  . SER A 1 202 ? -17.99889 15.85273 -4.70959  1.000 34.74530 ? 197 SER A CA  1 
ATOM   1558 C C   . SER A 1 202 ? -18.18020 15.20118 -6.07417  1.000 34.76340 ? 197 SER A C   1 
ATOM   1559 O O   . SER A 1 202 ? -17.52013 15.62990 -7.03040  1.000 32.35279 ? 197 SER A O   1 
ATOM   1560 C CB  . SER A 1 202 ? -16.55204 15.61860 -4.25291  1.000 34.63838 ? 197 SER A CB  1 
ATOM   1561 O OG  . SER A 1 202 ? -16.24185 14.22142 -4.20098  1.000 36.54144 ? 197 SER A OG  1 
ATOM   1562 N N   . GLU A 1 203 ? -19.05194 14.19057 -6.19133  1.000 31.11444 ? 198 GLU A N   1 
ATOM   1563 C CA  . GLU A 1 203 ? -19.06950 13.36154 -7.39704  1.000 30.36314 ? 198 GLU A CA  1 
ATOM   1564 C C   . GLU A 1 203 ? -19.28980 14.19469 -8.65422  1.000 32.51280 ? 198 GLU A C   1 
ATOM   1565 O O   . GLU A 1 203 ? -18.62198 13.97927 -9.67881  1.000 35.16420 ? 198 GLU A O   1 
ATOM   1566 C CB  . GLU A 1 203 ? -20.14875 12.27713 -7.29256  1.000 34.86753 ? 198 GLU A CB  1 
ATOM   1567 C CG  . GLU A 1 203 ? -20.23518 11.42683 -8.56042  1.000 37.74288 ? 198 GLU A CG  1 
ATOM   1568 C CD  . GLU A 1 203 ? -21.14195 10.21437 -8.41921  1.000 39.94875 ? 198 GLU A CD  1 
ATOM   1569 O OE1 . GLU A 1 203 ? -21.98459 10.19576 -7.49865  1.000 42.18839 ? 198 GLU A OE1 1 
ATOM   1570 O OE2 . GLU A 1 203 ? -21.00744 9.28100  -9.24101  1.000 42.04750 ? 198 GLU A OE2 1 
ATOM   1571 N N   . PHE A 1 204 ? -20.22538 15.14372 -8.60497  1.000 27.71446 ? 199 PHE A N   1 
ATOM   1572 C CA  . PHE A 1 204 ? -20.61136 15.88568 -9.79981  1.000 27.94965 ? 199 PHE A CA  1 
ATOM   1573 C C   . PHE A 1 204 ? -20.14318 17.32928 -9.77741  1.000 30.23903 ? 199 PHE A C   1 
ATOM   1574 O O   . PHE A 1 204 ? -20.71853 18.17500 -10.46633 1.000 28.97981 ? 199 PHE A O   1 
ATOM   1575 C CB  . PHE A 1 204 ? -22.12028 15.80250 -9.99574  1.000 31.33697 ? 199 PHE A CB  1 
ATOM   1576 C CG  . PHE A 1 204 ? -22.58137 14.40130 -10.19157 1.000 30.99260 ? 199 PHE A CG  1 
ATOM   1577 C CD1 . PHE A 1 204 ? -22.15022 13.68700 -11.29712 1.000 29.23314 ? 199 PHE A CD1 1 
ATOM   1578 C CD2 . PHE A 1 204 ? -23.38459 13.77842 -9.25686  1.000 34.28154 ? 199 PHE A CD2 1 
ATOM   1579 C CE1 . PHE A 1 204 ? -22.53503 12.36853 -11.48879 1.000 32.24944 ? 199 PHE A CE1 1 
ATOM   1580 C CE2 . PHE A 1 204 ? -23.77815 12.45894 -9.44108  1.000 33.29768 ? 199 PHE A CE2 1 
ATOM   1581 C CZ  . PHE A 1 204 ? -23.35175 11.76031 -10.56820 1.000 27.96044 ? 199 PHE A CZ  1 
ATOM   1582 N N   . VAL A 1 205 ? -19.11253 17.63212 -9.00750  1.000 27.61467 ? 200 VAL A N   1 
ATOM   1583 C CA  . VAL A 1 205 ? -18.46600 18.92951 -9.12907  1.000 27.65920 ? 200 VAL A CA  1 
ATOM   1584 C C   . VAL A 1 205 ? -17.57080 18.89140 -10.35860 1.000 26.33103 ? 200 VAL A C   1 
ATOM   1585 O O   . VAL A 1 205 ? -16.72369 18.00323 -10.49287 1.000 28.28466 ? 200 VAL A O   1 
ATOM   1586 C CB  . VAL A 1 205 ? -17.67053 19.26603 -7.86227  1.000 28.08733 ? 200 VAL A CB  1 
ATOM   1587 C CG1 . VAL A 1 205 ? -16.94144 20.58998 -8.06253  1.000 25.93218 ? 200 VAL A CG1 1 
ATOM   1588 C CG2 . VAL A 1 205 ? -18.60922 19.33186 -6.67193  1.000 29.58061 ? 200 VAL A CG2 1 
ATOM   1589 N N   . ALA A 1 206 ? -17.77446 19.84237 -11.26986 1.000 26.70653 ? 201 ALA A N   1 
ATOM   1590 C CA  . ALA A 1 206 ? -17.06603 19.82957 -12.54477 1.000 28.71817 ? 201 ALA A CA  1 
ATOM   1591 C C   . ALA A 1 206 ? -15.59473 20.19932 -12.41353 1.000 28.26942 ? 201 ALA A C   1 
ATOM   1592 O O   . ALA A 1 206 ? -14.80463 19.88605 -13.31072 1.000 31.38020 ? 201 ALA A O   1 
ATOM   1593 C CB  . ALA A 1 206 ? -17.74369 20.79298 -13.52293 1.000 26.18921 ? 201 ALA A CB  1 
ATOM   1594 N N   . TYR A 1 207 ? -15.21676 20.85814 -11.35612 1.000 24.03443 ? 202 TYR A N   1 
ATOM   1595 C CA  . TYR A 1 207 ? -13.86334 21.36255 -11.25980 1.000 23.42675 ? 202 TYR A CA  1 
ATOM   1596 C C   . TYR A 1 207 ? -13.07460 20.55217 -10.25526 1.000 26.35256 ? 202 TYR A C   1 
ATOM   1597 O O   . TYR A 1 207 ? -13.65501 19.96992 -9.33348  1.000 23.73599 ? 202 TYR A O   1 
ATOM   1598 C CB  . TYR A 1 207 ? -13.88269 22.83523 -10.84050 1.000 25.56475 ? 202 TYR A CB  1 
ATOM   1599 C CG  . TYR A 1 207 ? -14.85170 23.59146 -11.70093 1.000 25.30070 ? 202 TYR A CG  1 
ATOM   1600 C CD1 . TYR A 1 207 ? -14.56459 23.83798 -13.02730 1.000 23.74445 ? 202 TYR A CD1 1 
ATOM   1601 C CD2 . TYR A 1 207 ? -16.07242 24.01413 -11.19969 1.000 23.57869 ? 202 TYR A CD2 1 
ATOM   1602 C CE1 . TYR A 1 207 ? -15.44420 24.49967 -13.83766 1.000 23.83332 ? 202 TYR A CE1 1 
ATOM   1603 C CE2 . TYR A 1 207 ? -16.96708 24.69079 -11.99975 1.000 23.36760 ? 202 TYR A CE2 1 
ATOM   1604 C CZ  . TYR A 1 207 ? -16.65245 24.93061 -13.32115 1.000 25.80058 ? 202 TYR A CZ  1 
ATOM   1605 O OH  . TYR A 1 207 ? -17.54752 25.61363 -14.11984 1.000 24.90940 ? 202 TYR A OH  1 
ATOM   1606 N N   . PRO A 1 208 ? -11.75725 20.46411 -10.41609 1.000 27.55683 ? 203 PRO A N   1 
ATOM   1607 C CA  . PRO A 1 208 ? -10.95929 19.72131 -9.44114  1.000 26.70194 ? 203 PRO A CA  1 
ATOM   1608 C C   . PRO A 1 208 ? -11.08203 20.36176 -8.07063  1.000 24.79684 ? 203 PRO A C   1 
ATOM   1609 O O   . PRO A 1 208 ? -11.04374 21.58453 -7.93041  1.000 26.05705 ? 203 PRO A O   1 
ATOM   1610 C CB  . PRO A 1 208 ? -9.52945  19.82048 -9.98989  1.000 32.46459 ? 203 PRO A CB  1 
ATOM   1611 C CG  . PRO A 1 208 ? -9.55664  20.98362 -10.93446 1.000 29.24829 ? 203 PRO A CG  1 
ATOM   1612 C CD  . PRO A 1 208 ? -10.93824 21.01140 -11.50802 1.000 26.73003 ? 203 PRO A CD  1 
ATOM   1613 N N   . ILE A 1 209 ? -11.24232 19.52375 -7.05895  1.000 26.09258 ? 204 ILE A N   1 
ATOM   1614 C CA  . ILE A 1 209 ? -11.22460 19.96767 -5.67658  1.000 26.10973 ? 204 ILE A CA  1 
ATOM   1615 C C   . ILE A 1 209 ? -9.86932  19.56214 -5.12740  1.000 28.28522 ? 204 ILE A C   1 
ATOM   1616 O O   . ILE A 1 209 ? -9.58111  18.37031 -4.95852  1.000 29.40599 ? 204 ILE A O   1 
ATOM   1617 C CB  . ILE A 1 209 ? -12.37847 19.36919 -4.86426  1.000 24.19136 ? 204 ILE A CB  1 
ATOM   1618 C CG1 . ILE A 1 209 ? -13.71784 19.78632 -5.46773  1.000 23.77751 ? 204 ILE A CG1 1 
ATOM   1619 C CG2 . ILE A 1 209 ? -12.30988 19.83002 -3.42259  1.000 25.11408 ? 204 ILE A CG2 1 
ATOM   1620 C CD1 . ILE A 1 209 ? -14.90562 19.08705 -4.81094  1.000 27.23270 ? 204 ILE A CD1 1 
ATOM   1621 N N   . GLN A 1 210 ? -9.03138  20.55657 -4.87560  1.000 24.08839 ? 205 GLN A N   1 
ATOM   1622 C CA  . GLN A 1 210 ? -7.65132  20.33976 -4.47657  1.000 25.02433 ? 205 GLN A CA  1 
ATOM   1623 C C   . GLN A 1 210 ? -7.52555  20.50664 -2.97038  1.000 26.90500 ? 205 GLN A C   1 
ATOM   1624 O O   . GLN A 1 210 ? -8.05664  21.46551 -2.39712  1.000 30.12037 ? 205 GLN A O   1 
ATOM   1625 C CB  . GLN A 1 210 ? -6.73557  21.32468 -5.19751  1.000 27.18172 ? 205 GLN A CB  1 
ATOM   1626 C CG  . GLN A 1 210 ? -6.79237  21.21583 -6.71279  1.000 29.33909 ? 205 GLN A CG  1 
ATOM   1627 C CD  . GLN A 1 210 ? -6.04364  22.35220 -7.37966  1.000 33.71879 ? 205 GLN A CD  1 
ATOM   1628 O OE1 . GLN A 1 210 ? -5.69571  23.34487 -6.73129  1.000 33.22689 ? 205 GLN A OE1 1 
ATOM   1629 N NE2 . GLN A 1 210 ? -5.79813  22.22035 -8.68123  1.000 35.17807 ? 205 GLN A NE2 1 
ATOM   1630 N N   . LEU A 1 211 ? -6.85037  19.56434 -2.32927  1.000 21.88328 ? 206 LEU A N   1 
ATOM   1631 C CA  . LEU A 1 211 ? -6.58068  19.64865 -0.90481  1.000 23.89959 ? 206 LEU A CA  1 
ATOM   1632 C C   . LEU A 1 211 ? -5.08781  19.89197 -0.74568  1.000 24.94982 ? 206 LEU A C   1 
ATOM   1633 O O   . LEU A 1 211 ? -4.27927  19.09130 -1.22349  1.000 27.23763 ? 206 LEU A O   1 
ATOM   1634 C CB  . LEU A 1 211 ? -7.00375  18.36710 -0.18571  1.000 27.08663 ? 206 LEU A CB  1 
ATOM   1635 C CG  . LEU A 1 211 ? -6.73346  18.34897 1.31640   1.000 31.34550 ? 206 LEU A CG  1 
ATOM   1636 C CD1 . LEU A 1 211 ? -7.44716  19.51115 2.02456   1.000 27.84187 ? 206 LEU A CD1 1 
ATOM   1637 C CD2 . LEU A 1 211 ? -7.15792  17.01142 1.90120   1.000 32.26553 ? 206 LEU A CD2 1 
ATOM   1638 N N   . MET A 1 212 ? -4.72666  21.00206 -0.11353  1.000 23.91594 ? 207 MET A N   1 
ATOM   1639 C CA  . MET A 1 212 ? -3.31902  21.32432 0.08687   1.000 24.84070 ? 207 MET A CA  1 
ATOM   1640 C C   . MET A 1 212 ? -2.86834  20.60891 1.34200   1.000 31.88420 ? 207 MET A C   1 
ATOM   1641 O O   . MET A 1 212 ? -3.34124  20.91903 2.43892   1.000 33.84777 ? 207 MET A O   1 
ATOM   1642 C CB  . MET A 1 212 ? -3.10644  22.83071 0.21297   1.000 27.48136 ? 207 MET A CB  1 
ATOM   1643 C CG  . MET A 1 212 ? -3.48277  23.59003 -1.03277  1.000 31.36036 ? 207 MET A CG  1 
ATOM   1644 S SD  . MET A 1 212 ? -2.63171  22.94561 -2.47787  1.000 43.75225 ? 207 MET A SD  1 
ATOM   1645 C CE  . MET A 1 212 ? -0.92716  23.09611 -1.87913  1.000 35.56963 ? 207 MET A CE  1 
ATOM   1646 N N   . VAL A 1 213 ? -1.97278  19.64179 1.19253   1.000 30.37341 ? 208 VAL A N   1 
ATOM   1647 C CA  . VAL A 1 213 ? -1.52084  18.85880 2.33081   1.000 38.52260 ? 208 VAL A CA  1 
ATOM   1648 C C   . VAL A 1 213 ? -0.02620  19.07128 2.49229   1.000 32.78469 ? 208 VAL A C   1 
ATOM   1649 O O   . VAL A 1 213 ? 0.70990   19.21752 1.51093   1.000 30.90284 ? 208 VAL A O   1 
ATOM   1650 C CB  . VAL A 1 213 ? -1.87351  17.35910 2.20262   1.000 35.49018 ? 208 VAL A CB  1 
ATOM   1651 C CG1 . VAL A 1 213 ? -3.21035  17.16439 1.49652   1.000 39.42836 ? 208 VAL A CG1 1 
ATOM   1652 C CG2 . VAL A 1 213 ? -0.79170  16.57653 1.50981   1.000 38.34382 ? 208 VAL A CG2 1 
ATOM   1653 N N   . THR A 1 214 ? 0.40451   19.15066 3.73583   1.000 32.26738 ? 209 THR A N   1 
ATOM   1654 C CA  . THR A 1 214 ? 1.81303   19.28884 4.04722   1.000 36.55061 ? 209 THR A CA  1 
ATOM   1655 C C   . THR A 1 214 ? 2.38691   17.90490 4.30196   1.000 35.50403 ? 209 THR A C   1 
ATOM   1656 O O   . THR A 1 214 ? 1.89012   17.17978 5.16848   1.000 38.44129 ? 209 THR A O   1 
ATOM   1657 C CB  . THR A 1 214 ? 1.97612   20.19091 5.26058   1.000 39.39318 ? 209 THR A CB  1 
ATOM   1658 O OG1 . THR A 1 214 ? 1.00436   21.24530 5.17442   1.000 46.56095 ? 209 THR A OG1 1 
ATOM   1659 C CG2 . THR A 1 214 ? 3.33222   20.79221 5.26346   1.000 34.92823 ? 209 THR A CG2 1 
ATOM   1660 N N   . LYS A 1 215 ? 3.41251   17.53116 3.53783   1.000 31.64350 ? 210 LYS A N   1 
ATOM   1661 C CA  . LYS A 1 215 ? 4.13039   16.27967 3.72993   1.000 33.61823 ? 210 LYS A CA  1 
ATOM   1662 C C   . LYS A 1 215 ? 5.52027   16.59151 4.26895   1.000 33.70344 ? 210 LYS A C   1 
ATOM   1663 O O   . LYS A 1 215 ? 6.25363   17.38315 3.67097   1.000 31.84887 ? 210 LYS A O   1 
ATOM   1664 C CB  . LYS A 1 215 ? 4.25908   15.50210 2.41697   1.000 35.83453 ? 210 LYS A CB  1 
ATOM   1665 C CG  . LYS A 1 215 ? 2.96937   15.01645 1.79459   1.000 42.28917 ? 210 LYS A CG  1 
ATOM   1666 C CD  . LYS A 1 215 ? 3.26954   14.14599 0.57054   1.000 42.33579 ? 210 LYS A CD  1 
ATOM   1667 C CE  . LYS A 1 215 ? 2.00288   13.48525 0.02509   1.000 44.75093 ? 210 LYS A CE  1 
ATOM   1668 N NZ  . LYS A 1 215 ? 2.28119   12.55272 -1.10749  1.000 45.51345 ? 210 LYS A NZ  1 
ATOM   1669 N N   . GLU A 1 216 ? 5.89327   15.97357 5.38097   1.000 34.48865 ? 211 GLU A N   1 
ATOM   1670 C CA  . GLU A 1 216 ? 7.26533   16.12217 5.84828   1.000 38.10759 ? 211 GLU A CA  1 
ATOM   1671 C C   . GLU A 1 216 ? 8.16594   15.18967 5.05879   1.000 37.76387 ? 211 GLU A C   1 
ATOM   1672 O O   . GLU A 1 216 ? 7.86645   14.00343 4.92572   1.000 37.70792 ? 211 GLU A O   1 
ATOM   1673 C CB  . GLU A 1 216 ? 7.38604   15.82072 7.33745   1.000 40.18858 ? 211 GLU A CB  1 
ATOM   1674 C CG  . GLU A 1 216 ? 7.10129   17.00098 8.21802   1.000 44.35945 ? 211 GLU A CG  1 
ATOM   1675 C CD  . GLU A 1 216 ? 7.57127   16.78226 9.64144   1.000 46.82711 ? 211 GLU A CD  1 
ATOM   1676 O OE1 . GLU A 1 216 ? 8.67130   16.21785 9.82783   1.000 54.07487 ? 211 GLU A OE1 1 
ATOM   1677 O OE2 . GLU A 1 216 ? 6.83725   17.17345 10.57032  1.000 49.53722 ? 211 GLU A OE2 1 
ATOM   1678 N N   . VAL A 1 217 ? 9.25139   15.73259 4.51440   1.000 32.23993 ? 212 VAL A N   1 
ATOM   1679 C CA  . VAL A 1 217 ? 10.27115  14.92206 3.86804   1.000 37.39028 ? 212 VAL A CA  1 
ATOM   1680 C C   . VAL A 1 217 ? 11.26122  14.43892 4.92365   1.000 41.07841 ? 212 VAL A C   1 
ATOM   1681 O O   . VAL A 1 217 ? 11.39484  13.23474 5.13338   1.000 54.62010 ? 212 VAL A O   1 
ATOM   1682 C CB  . VAL A 1 217 ? 10.99808  15.68977 2.77580   1.000 35.21057 ? 212 VAL A CB  1 
ATOM   1683 C CG1 . VAL A 1 217 ? 11.91369  14.75390 2.00034   1.000 36.10352 ? 212 VAL A CG1 1 
ATOM   1684 C CG2 . VAL A 1 217 ? 10.00794  16.39108 1.86181   1.000 31.42115 ? 212 VAL A CG2 1 
HETATM 1685 O O   . HOH B 2 .   ? -25.70909 38.12853 14.22880  1.000 40.67770 ? 301 HOH A O   1 
HETATM 1686 O O   . HOH B 2 .   ? -4.96044  32.97981 -9.20297  1.000 39.28606 ? 302 HOH A O   1 
HETATM 1687 O O   . HOH B 2 .   ? -31.07045 25.05943 15.64271  1.000 46.71914 ? 303 HOH A O   1 
HETATM 1688 O O   . HOH B 2 .   ? -24.30417 14.77877 3.47852   1.000 43.51410 ? 304 HOH A O   1 
HETATM 1689 O O   . HOH B 2 .   ? -11.80530 21.24206 18.10604  1.000 37.22161 ? 305 HOH A O   1 
HETATM 1690 O O   . HOH B 2 .   ? -10.23365 42.55830 7.52017   1.000 34.11972 ? 306 HOH A O   1 
HETATM 1691 O O   . HOH B 2 .   ? -3.22294  37.32546 -13.04201 1.000 38.13098 ? 307 HOH A O   1 
HETATM 1692 O O   . HOH B 2 .   ? -28.00134 18.97450 17.91499  1.000 38.41585 ? 308 HOH A O   1 
HETATM 1693 O O   . HOH B 2 .   ? -10.01314 50.27223 2.40933   1.000 39.26848 ? 309 HOH A O   1 
HETATM 1694 O O   . HOH B 2 .   ? -11.48656 38.60774 -24.99285 1.000 33.59930 ? 310 HOH A O   1 
HETATM 1695 O O   . HOH B 2 .   ? -44.02369 32.16911 5.69284   1.000 42.90006 ? 311 HOH A O   1 
HETATM 1696 O O   . HOH B 2 .   ? -19.59271 22.00878 -10.91335 1.000 29.32280 ? 312 HOH A O   1 
HETATM 1697 O O   . HOH B 2 .   ? -29.15160 29.29444 17.21548  1.000 40.47631 ? 313 HOH A O   1 
HETATM 1698 O O   . HOH B 2 .   ? -11.63090 49.93798 -5.85598  1.000 41.53538 ? 314 HOH A O   1 
HETATM 1699 O O   . HOH B 2 .   ? -17.83024 17.58400 15.73881  1.000 48.67566 ? 315 HOH A O   1 
HETATM 1700 O O   . HOH B 2 .   ? -7.75762  9.17709  -0.08187  1.000 52.20038 ? 316 HOH A O   1 
HETATM 1701 O O   . HOH B 2 .   ? -21.92985 25.17392 -10.25533 1.000 26.77464 ? 317 HOH A O   1 
HETATM 1702 O O   . HOH B 2 .   ? -25.22476 17.43528 -4.34583  1.000 43.74319 ? 318 HOH A O   1 
HETATM 1703 O O   . HOH B 2 .   ? -14.97676 33.96145 -7.02121  1.000 23.21390 ? 319 HOH A O   1 
HETATM 1704 O O   . HOH B 2 .   ? -12.68171 49.77985 2.05655   1.000 41.21955 ? 320 HOH A O   1 
HETATM 1705 O O   . HOH B 2 .   ? -7.20056  33.90775 -24.17112 1.000 49.97341 ? 321 HOH A O   1 
HETATM 1706 O O   . HOH B 2 .   ? -5.13220  40.34895 -6.79594  1.000 25.98944 ? 322 HOH A O   1 
HETATM 1707 O O   . HOH B 2 .   ? -36.02433 42.64331 11.05482  1.000 40.06885 ? 323 HOH A O   1 
HETATM 1708 O O   . HOH B 2 .   ? -7.13969  27.20651 -0.37394  1.000 23.37396 ? 324 HOH A O   1 
HETATM 1709 O O   . HOH B 2 .   ? 5.63873   19.37803 9.82826   1.000 49.82164 ? 325 HOH A O   1 
HETATM 1710 O O   . HOH B 2 .   ? 1.98199   29.69967 9.94479   1.000 53.02676 ? 326 HOH A O   1 
HETATM 1711 O O   . HOH B 2 .   ? -8.60691  39.57162 -11.47785 1.000 26.01989 ? 327 HOH A O   1 
HETATM 1712 O O   . HOH B 2 .   ? -5.73254  32.86373 13.52376  1.000 43.40694 ? 328 HOH A O   1 
HETATM 1713 O O   . HOH B 2 .   ? -3.24532  27.36746 -0.46873  1.000 34.46575 ? 329 HOH A O   1 
HETATM 1714 O O   . HOH B 2 .   ? -19.36599 19.14779 -3.12852  1.000 34.12347 ? 330 HOH A O   1 
HETATM 1715 O O   . HOH B 2 .   ? -35.28962 23.56978 12.05389  1.000 39.84621 ? 331 HOH A O   1 
HETATM 1716 O O   . HOH B 2 .   ? -8.73207  32.78729 -22.57935 1.000 36.37445 ? 332 HOH A O   1 
HETATM 1717 O O   . HOH B 2 .   ? -23.32351 26.94904 15.29659  1.000 32.28540 ? 333 HOH A O   1 
HETATM 1718 O O   . HOH B 2 .   ? -5.13204  23.74016 15.00456  1.000 46.86241 ? 334 HOH A O   1 
HETATM 1719 O O   . HOH B 2 .   ? -22.41693 20.04639 -11.26414 1.000 39.84194 ? 335 HOH A O   1 
HETATM 1720 O O   . HOH B 2 .   ? -24.67874 27.22353 -1.21730  1.000 28.63567 ? 336 HOH A O   1 
HETATM 1721 O O   . HOH B 2 .   ? -18.75589 19.15695 13.63264  1.000 38.74998 ? 337 HOH A O   1 
HETATM 1722 O O   . HOH B 2 .   ? -20.74440 19.05953 3.41590   1.000 27.30213 ? 338 HOH A O   1 
HETATM 1723 O O   . HOH B 2 .   ? -15.44405 29.49944 -21.15071 1.000 33.17309 ? 339 HOH A O   1 
HETATM 1724 O O   . HOH B 2 .   ? -24.40285 27.36473 -4.60240  1.000 31.60917 ? 340 HOH A O   1 
HETATM 1725 O O   . HOH B 2 .   ? -37.08150 39.11207 10.05970  1.000 54.15282 ? 341 HOH A O   1 
HETATM 1726 O O   . HOH B 2 .   ? -9.01913  22.74450 -13.93127 1.000 34.83998 ? 342 HOH A O   1 
HETATM 1727 O O   . HOH B 2 .   ? -18.92142 39.07943 -9.45146  1.000 33.46811 ? 343 HOH A O   1 
HETATM 1728 O O   . HOH B 2 .   ? -44.25328 23.17527 11.47073  1.000 35.50817 ? 344 HOH A O   1 
HETATM 1729 O O   . HOH B 2 .   ? -7.75700  39.60990 -18.60958 1.000 40.39376 ? 345 HOH A O   1 
HETATM 1730 O O   . HOH B 2 .   ? -19.46780 17.65567 1.41414   1.000 30.64891 ? 346 HOH A O   1 
HETATM 1731 O O   . HOH B 2 .   ? -17.01728 9.93870  2.82237   1.000 35.93269 ? 347 HOH A O   1 
HETATM 1732 O O   . HOH B 2 .   ? -40.331   30.000   3.912     1.000 29.53482 ? 348 HOH A O   1 
HETATM 1733 O O   . HOH B 2 .   ? -12.28622 42.80415 -6.73803  1.000 21.62128 ? 349 HOH A O   1 
HETATM 1734 O O   . HOH B 2 .   ? -21.02733 31.83263 -5.84639  1.000 30.51145 ? 350 HOH A O   1 
HETATM 1735 O O   . HOH B 2 .   ? -5.36802  44.53611 -6.01486  1.000 30.37782 ? 351 HOH A O   1 
HETATM 1736 O O   . HOH B 2 .   ? -13.44176 38.65934 -12.90986 1.000 24.66101 ? 352 HOH A O   1 
HETATM 1737 O O   . HOH B 2 .   ? -12.20546 44.20144 6.21985   1.000 26.28576 ? 353 HOH A O   1 
HETATM 1738 O O   . HOH B 2 .   ? -16.704   40.748   -20.455   1.000 37.61473 ? 354 HOH A O   1 
HETATM 1739 O O   . HOH B 2 .   ? -23.90465 50.77902 6.80741   1.000 43.60918 ? 355 HOH A O   1 
HETATM 1740 O O   . HOH B 2 .   ? -3.71325  32.75541 -1.54975  1.000 37.56218 ? 356 HOH A O   1 
HETATM 1741 O O   . HOH B 2 .   ? -26.62278 21.24051 2.89443   1.000 31.70200 ? 357 HOH A O   1 
HETATM 1742 O O   . HOH B 2 .   ? -14.75232 41.38627 -15.99972 1.000 35.17334 ? 358 HOH A O   1 
HETATM 1743 O O   . HOH B 2 .   ? -19.94908 12.46009 -3.88179  1.000 39.85419 ? 359 HOH A O   1 
HETATM 1744 O O   . HOH B 2 .   ? -15.39848 39.32365 -14.50623 1.000 30.46148 ? 360 HOH A O   1 
HETATM 1745 O O   . HOH B 2 .   ? -18.34116 30.41356 19.44509  1.000 47.12640 ? 361 HOH A O   1 
HETATM 1746 O O   . HOH B 2 .   ? -20.98493 21.09634 -3.22104  1.000 30.35929 ? 362 HOH A O   1 
HETATM 1747 O O   . HOH B 2 .   ? -14.35713 28.97119 19.46071  1.000 37.90158 ? 363 HOH A O   1 
HETATM 1748 O O   . HOH B 2 .   ? -29.89868 22.94742 0.46053   1.000 39.88508 ? 364 HOH A O   1 
HETATM 1749 O O   . HOH B 2 .   ? -21.77941 16.41280 -6.70580  1.000 34.02836 ? 365 HOH A O   1 
HETATM 1750 O O   . HOH B 2 .   ? -14.45710 29.87664 -2.35154  1.000 25.50557 ? 366 HOH A O   1 
HETATM 1751 O O   . HOH B 2 .   ? -21.94239 18.87684 15.59443  1.000 53.38534 ? 367 HOH A O   1 
HETATM 1752 O O   . HOH B 2 .   ? -5.67678  45.37730 -2.97702  1.000 26.46101 ? 368 HOH A O   1 
HETATM 1753 O O   . HOH B 2 .   ? -2.48286  35.18483 1.14244   1.000 30.73061 ? 369 HOH A O   1 
HETATM 1754 O O   . HOH B 2 .   ? -0.86417  46.15092 -1.07599  1.000 39.92119 ? 370 HOH A O   1 
HETATM 1755 O O   . HOH B 2 .   ? -3.72417  48.28092 5.32177   1.000 49.22160 ? 371 HOH A O   1 
HETATM 1756 O O   . HOH B 2 .   ? -26.57520 29.15701 -1.36127  1.000 26.89319 ? 372 HOH A O   1 
HETATM 1757 O O   . HOH B 2 .   ? -27.67529 22.34628 -0.93130  1.000 39.75532 ? 373 HOH A O   1 
HETATM 1758 O O   . HOH B 2 .   ? -0.17533  46.45101 5.20486   1.000 46.04530 ? 374 HOH A O   1 
HETATM 1759 O O   . HOH B 2 .   ? -1.89219  22.17129 4.48703   1.000 41.51549 ? 375 HOH A O   1 
HETATM 1760 O O   . HOH B 2 .   ? -20.48424 23.30664 -13.13844 1.000 31.15661 ? 376 HOH A O   1 
HETATM 1761 O O   . HOH B 2 .   ? -15.056   40.246   -26.328   1.000 34.67221 ? 377 HOH A O   1 
HETATM 1762 O O   . HOH B 2 .   ? -6.55256  29.83288 -0.19085  1.000 30.16119 ? 378 HOH A O   1 
HETATM 1763 O O   . HOH B 2 .   ? -4.00563  32.74474 1.67027   1.000 38.05407 ? 379 HOH A O   1 
HETATM 1764 O O   . HOH B 2 .   ? -29.365   37.872   17.831    1.000 50.36754 ? 380 HOH A O   1 
HETATM 1765 O O   . HOH B 2 .   ? -8.01768  42.52090 -14.78844 1.000 39.65053 ? 381 HOH A O   1 
HETATM 1766 O O   . HOH B 2 .   ? -23.45799 15.76232 5.29571   1.000 41.53365 ? 382 HOH A O   1 
HETATM 1767 O O   . HOH B 2 .   ? -20.975   35.375   -22.359   1.000 29.51556 ? 383 HOH A O   1 
HETATM 1768 O O   . HOH B 2 .   ? -17.04485 32.32483 -4.34034  1.000 31.56173 ? 384 HOH A O   1 
HETATM 1769 O O   . HOH B 2 .   ? -2.61021  34.08599 -18.69386 1.000 39.77625 ? 385 HOH A O   1 
HETATM 1770 O O   . HOH B 2 .   ? -32.03429 46.36301 7.99607   1.000 40.94823 ? 386 HOH A O   1 
HETATM 1771 O O   . HOH B 2 .   ? -17.66077 40.60602 -13.01506 1.000 41.68334 ? 387 HOH A O   1 
HETATM 1772 O O   . HOH B 2 .   ? -20.53319 28.09030 -17.22085 1.000 34.59132 ? 388 HOH A O   1 
HETATM 1773 O O   . HOH B 2 .   ? -11.14142 51.66387 -1.30482  1.000 44.76354 ? 389 HOH A O   1 
HETATM 1774 O O   . HOH B 2 .   ? -10.80943 10.10665 4.75740   1.000 41.46671 ? 390 HOH A O   1 
HETATM 1775 O O   . HOH B 2 .   ? -6.66345  39.43216 5.76256   1.000 28.90483 ? 391 HOH A O   1 
HETATM 1776 O O   . HOH B 2 .   ? -24.88254 31.69947 -0.55569  1.000 20.10267 ? 392 HOH A O   1 
HETATM 1777 O O   . HOH B 2 .   ? -15.547   17.764   -15.104   1.000 40.34345 ? 393 HOH A O   1 
HETATM 1778 O O   . HOH B 2 .   ? -4.98850  39.92459 -11.63399 1.000 36.83286 ? 394 HOH A O   1 
HETATM 1779 O O   . HOH B 2 .   ? -27.85627 44.69109 11.64161  1.000 46.86064 ? 395 HOH A O   1 
HETATM 1780 O O   . HOH B 2 .   ? -16.88026 29.40342 -1.36599  1.000 22.85402 ? 396 HOH A O   1 
HETATM 1781 O O   . HOH B 2 .   ? -8.29190  24.71819 -15.68242 1.000 35.96285 ? 397 HOH A O   1 
HETATM 1782 O O   . HOH B 2 .   ? -6.79578  44.21294 -11.95307 1.000 37.72155 ? 398 HOH A O   1 
HETATM 1783 O O   . HOH B 2 .   ? -0.48732  28.60985 7.41590   1.000 45.37816 ? 399 HOH A O   1 
HETATM 1784 O O   . HOH B 2 .   ? -12.89488 43.52327 10.73278  1.000 43.43637 ? 400 HOH A O   1 
HETATM 1785 O O   . HOH B 2 .   ? -36.04470 19.94502 5.73769   1.000 29.72510 ? 401 HOH A O   1 
HETATM 1786 O O   . HOH B 2 .   ? -5.44506  45.05130 4.24638   1.000 29.90661 ? 402 HOH A O   1 
HETATM 1787 O O   . HOH B 2 .   ? -35.44512 36.16792 13.14599  1.000 50.53224 ? 403 HOH A O   1 
HETATM 1788 O O   . HOH B 2 .   ? -16.34685 48.31634 -6.74857  1.000 27.49090 ? 404 HOH A O   1 
HETATM 1789 O O   . HOH B 2 .   ? -24.71874 47.59552 -1.96140  1.000 50.24784 ? 405 HOH A O   1 
HETATM 1790 O O   . HOH B 2 .   ? -17.73330 26.94320 -21.10658 1.000 41.47729 ? 406 HOH A O   1 
HETATM 1791 O O   . HOH B 2 .   ? -24.64615 35.86543 18.46812  1.000 53.80066 ? 407 HOH A O   1 
HETATM 1792 O O   . HOH B 2 .   ? -2.29760  37.78816 5.91081   1.000 41.26143 ? 408 HOH A O   1 
HETATM 1793 O O   . HOH B 2 .   ? -21.34961 17.26784 10.99713  1.000 33.12140 ? 409 HOH A O   1 
HETATM 1794 O O   . HOH B 2 .   ? -1.90420  47.13940 6.49120   1.000 51.82833 ? 410 HOH A O   1 
HETATM 1795 O O   . HOH B 2 .   ? -11.98348 9.59694  2.58240   1.000 43.44740 ? 411 HOH A O   1 
HETATM 1796 O O   . HOH B 2 .   ? -6.05906  42.17717 -12.48976 1.000 43.89861 ? 412 HOH A O   1 
HETATM 1797 O O   . HOH B 2 .   ? -20.367   9.703    -12.152   1.000 39.52186 ? 413 HOH A O   1 
HETATM 1798 O O   . HOH B 2 .   ? -23.16539 17.69447 3.51961   1.000 36.69419 ? 414 HOH A O   1 
HETATM 1799 O O   . HOH B 2 .   ? -36.16424 30.58564 12.86458  1.000 45.53368 ? 415 HOH A O   1 
HETATM 1800 O O   . HOH B 2 .   ? -16.33334 53.43962 8.38796   1.000 47.19055 ? 416 HOH A O   1 
HETATM 1801 O O   . HOH B 2 .   ? -6.91466  40.80330 9.92769   1.000 47.47229 ? 417 HOH A O   1 
HETATM 1802 O O   . HOH B 2 .   ? -21.61231 30.67249 19.57078  1.000 47.77929 ? 418 HOH A O   1 
HETATM 1803 O O   . HOH B 2 .   ? -25.77159 18.71492 2.95723   1.000 34.23044 ? 419 HOH A O   1 
HETATM 1804 O O   . HOH B 2 .   ? -4.00820  16.65765 8.57149   1.000 39.38212 ? 420 HOH A O   1 
HETATM 1805 O O   . HOH B 2 .   ? -1.62098  18.42944 5.92987   1.000 44.39032 ? 421 HOH A O   1 
HETATM 1806 O O   . HOH B 2 .   ? -3.79860  28.84344 -2.72870  1.000 40.25803 ? 422 HOH A O   1 
HETATM 1807 O O   . HOH B 2 .   ? -30.07798 25.48756 18.42272  1.000 48.33276 ? 423 HOH A O   1 
HETATM 1808 O O   . HOH B 2 .   ? -18.830   22.574   -19.824   1.000 45.15550 ? 424 HOH A O   1 
HETATM 1809 O O   . HOH B 2 .   ? -26.63297 23.80305 -2.43675  1.000 41.87655 ? 425 HOH A O   1 
HETATM 1810 O O   . HOH B 2 .   ? -4.38689  47.29528 -4.46480  1.000 42.33931 ? 426 HOH A O   1 
HETATM 1811 O O   . HOH B 2 .   ? -5.47375  30.86046 -2.62613  1.000 34.00178 ? 427 HOH A O   1 
HETATM 1812 O O   . HOH B 2 .   ? -23.82696 20.30512 18.02634  1.000 46.60867 ? 428 HOH A O   1 
HETATM 1813 O O   . HOH B 2 .   ? -3.35043  32.43761 -6.99778  1.000 48.74714 ? 429 HOH A O   1 
HETATM 1814 O O   . HOH B 2 .   ? -26.90341 26.86805 -3.78570  1.000 42.98959 ? 430 HOH A O   1 
HETATM 1815 O O   . HOH B 2 .   ? 0.88023   31.87934 -1.57482  1.000 44.47122 ? 431 HOH A O   1 
HETATM 1816 O O   . HOH B 2 .   ? -32.48134 21.95411 11.61332  1.000 38.63260 ? 432 HOH A O   1 
HETATM 1817 O O   . HOH B 2 .   ? -31.87073 42.07127 13.58212  0.50  42.43864 ? 433 HOH A O   1 
HETATM 1818 O O   . HOH B 2 .   ? -0.21015  26.48867 9.75646   1.000 44.36937 ? 434 HOH A O   1 
HETATM 1819 O O   . HOH B 2 .   ? -2.63035  30.22944 -6.61685  1.000 38.37596 ? 435 HOH A O   1 
HETATM 1820 O O   . HOH B 2 .   ? -6.88377  38.67261 11.86158  1.000 53.09751 ? 436 HOH A O   1 
HETATM 1821 O O   . HOH B 2 .   ? -31.17236 27.37587 16.50206  1.000 46.25473 ? 437 HOH A O   1 
HETATM 1822 O O   . HOH B 2 .   ? -4.48361  38.60473 7.31457   1.000 37.70179 ? 438 HOH A O   1 
HETATM 1823 O O   . HOH B 2 .   ? -19.01168 31.48113 -1.17110  1.000 34.88280 ? 439 HOH A O   1 
HETATM 1824 O O   . HOH B 2 .   ? -18.66862 18.47345 -0.89273  1.000 33.07444 ? 440 HOH A O   1 
HETATM 1825 O O   . HOH B 2 .   ? -1.98507  20.79009 6.72530   1.000 47.02524 ? 441 HOH A O   1 
HETATM 1826 O O   . HOH B 2 .   ? -13.472   42.209   -25.927   1.000 45.05678 ? 442 HOH A O   1 
HETATM 1827 O O   . HOH B 2 .   ? -25.65833 34.77755 -0.36176  1.000 40.67947 ? 443 HOH A O   1 
HETATM 1828 O O   . HOH B 2 .   ? -7.31708  41.86243 7.22780   1.000 41.02483 ? 444 HOH A O   1 
HETATM 1829 O O   . HOH B 2 .   ? -23.46422 19.11506 -4.30092  1.000 49.85963 ? 445 HOH A O   1 
HETATM 1830 O O   . HOH B 2 .   ? -23.22717 23.22717 -13.58212 0.50  42.07665 ? 446 HOH A O   1 
HETATM 1831 O O   . HOH B 2 .   ? -17.56247 35.00229 -6.17350  1.000 33.91153 ? 447 HOH A O   1 
HETATM 1832 O O   . HOH B 2 .   ? -18.573   32.860   -29.408   1.000 48.57882 ? 448 HOH A O   1 
HETATM 1833 O O   . HOH B 2 .   ? -20.41371 33.37912 -2.67843  1.000 47.33043 ? 449 HOH A O   1 
HETATM 1834 O O   . HOH B 2 .   ? -22.65952 52.31594 8.34663   1.000 55.86280 ? 450 HOH A O   1 
HETATM 1835 O O   . HOH B 2 .   ? -20.40172 39.45868 -12.00953 1.000 46.36102 ? 451 HOH A O   1 
HETATM 1836 O O   . HOH B 2 .   ? -27.61140 17.13920 4.26196   1.000 40.50108 ? 452 HOH A O   1 
HETATM 1837 O O   . HOH B 2 .   ? -7.28846  34.09559 15.02492  1.000 52.33062 ? 453 HOH A O   1 
HETATM 1838 O O   . HOH B 2 .   ? -20.30750 16.41030 13.14461  1.000 49.83864 ? 454 HOH A O   1 
HETATM 1839 O O   . HOH B 2 .   ? -21.08939 33.68043 -7.60275  1.000 41.61708 ? 455 HOH A O   1 
HETATM 1840 O O   . HOH B 2 .   ? -2.30721  47.76311 -2.88575  1.000 46.35712 ? 456 HOH A O   1 
HETATM 1841 O O   . HOH B 2 .   ? -35.75823 28.72488 14.39304  1.000 43.47633 ? 457 HOH A O   1 
HETATM 1842 O O   . HOH B 2 .   ? -18.765   39.866   -23.062   1.000 37.64009 ? 458 HOH A O   1 
HETATM 1843 O O   . HOH B 2 .   ? -17.20008 48.43449 -8.85843  1.000 45.31344 ? 459 HOH A O   1 
HETATM 1844 O O   . HOH B 2 .   ? -2.53736  35.39981 7.02540   1.000 44.07187 ? 460 HOH A O   1 
HETATM 1845 O O   . HOH B 2 .   ? -4.40833  33.96421 8.69498   1.000 45.50293 ? 461 HOH A O   1 
HETATM 1846 O O   . HOH B 2 .   ? -19.75747 27.80927 -19.96890 1.000 35.37353 ? 462 HOH A O   1 
HETATM 1847 O O   . HOH B 2 .   ? -16.70098 50.57312 -5.33804  1.000 38.89469 ? 463 HOH A O   1 
HETATM 1848 O O   . HOH B 2 .   ? -33.87508 25.99999 14.00958  1.000 48.29878 ? 464 HOH A O   1 
HETATM 1849 O O   . HOH B 2 .   ? -14.867   24.349   -22.283   1.000 44.01445 ? 465 HOH A O   1 
HETATM 1850 O O   . HOH B 2 .   ? -36.390   21.627   14.118    1.000 40.51301 ? 466 HOH A O   1 
HETATM 1851 O O   . HOH B 2 .   ? -9.36373  41.99367 -17.91675 1.000 48.50801 ? 467 HOH A O   1 
HETATM 1852 O O   . HOH B 2 .   ? -31.97379 23.44283 13.84613  1.000 48.85375 ? 468 HOH A O   1 
HETATM 1853 O O   . HOH B 2 .   ? -30.15281 43.78919 13.58212  0.50  43.41616 ? 469 HOH A O   1 
HETATM 1854 O O   . HOH B 2 .   ? -9.72655  30.82389 -23.41266 1.000 51.15248 ? 470 HOH A O   1 
HETATM 1855 O O   . HOH B 2 .   ? -4.05611  42.78469 -7.50298  1.000 30.52229 ? 471 HOH A O   1 
HETATM 1856 O O   . HOH B 2 .   ? -19.95184 35.69861 -7.42815  1.000 43.64022 ? 472 HOH A O   1 
HETATM 1857 O O   . HOH B 2 .   ? -35.76445 26.70777 16.19505  1.000 59.55662 ? 473 HOH A O   1 
HETATM 1858 O O   . HOH B 2 .   ? -18.22070 33.64952 -2.65370  1.000 46.08917 ? 474 HOH A O   1 
HETATM 1859 O O   . HOH B 2 .   ? -6.29548  44.16398 6.79069   1.000 35.61725 ? 475 HOH A O   1 
HETATM 1860 O O   . HOH B 2 .   ? -1.49352  43.48291 -7.44333  1.000 35.60781 ? 476 HOH A O   1 
# 
