data_8YDV
# 
_entry.id   8YDV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YDV         pdb_00008ydv 10.2210/pdb8ydv/pdb 
WWPDB D_1300045367 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YDV 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              yoshi.cesp@tmd.ac.jp 
_pdbx_contact_author.name_first         Yoshinori 
_pdbx_contact_author.name_last          Fujiyoshi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8070-1493 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nakamura, S.'  1 0000-0003-2253-6976 
'Numoto, N.'    2 0000-0001-6113-9792 
'Fujiyoshi, Y.' 3 0000-0002-8070-1493 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Development of a short-peptide inhibiting any SARS-CoV-2 variants based on structural biology' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nakamura, S.'  1  0000-0003-2253-6976 
primary 'Tanimura, Y.'  2  ?                   
primary 'Nomura, R.'    3  ?                   
primary 'Suzuki, H.'    4  ?                   
primary 'Nishikawa, K.' 5  ?                   
primary 'Kamegawa, A.'  6  ?                   
primary 'Numoto, N.'    7  ?                   
primary 'Tanaka, A.'    8  ?                   
primary 'Kawabata, S.'  9  ?                   
primary 'Sakaguchi, S.' 10 ?                   
primary 'Emi, A.'       11 ?                   
primary 'Suzuki, Y.'    12 ?                   
primary 'Fujiyoshi, Y.' 13 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 'SARS-CoV-2 inhibiting peptide CeSPIACE' 4721.475  2   ? ? ? ? 
2 polymer     man 'Spike protein S1'                       26271.277 2   ? ? ? ? 
3 non-polymer syn GLYCEROL                                 92.094    9   ? ? ? ? 
4 water       nat water                                    18.015    297 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no DKLWILQKIYEIMVRLDEEGHGEASLMVSDLIYEFMKRD DKLWILQKIYEIMVRLDEEGHGEASLMVSDLIYEFMKRD A,C ? 
2 'polypeptide(L)' no no 
;TNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFSAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAP
GQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPL
QSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
;TNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFSAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAP
GQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFPL
QSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 GLYCEROL GOL 
4 water    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   LYS n 
1 3   LEU n 
1 4   TRP n 
1 5   ILE n 
1 6   LEU n 
1 7   GLN n 
1 8   LYS n 
1 9   ILE n 
1 10  TYR n 
1 11  GLU n 
1 12  ILE n 
1 13  MET n 
1 14  VAL n 
1 15  ARG n 
1 16  LEU n 
1 17  ASP n 
1 18  GLU n 
1 19  GLU n 
1 20  GLY n 
1 21  HIS n 
1 22  GLY n 
1 23  GLU n 
1 24  ALA n 
1 25  SER n 
1 26  LEU n 
1 27  MET n 
1 28  VAL n 
1 29  SER n 
1 30  ASP n 
1 31  LEU n 
1 32  ILE n 
1 33  TYR n 
1 34  GLU n 
1 35  PHE n 
1 36  MET n 
1 37  LYS n 
1 38  ARG n 
1 39  ASP n 
2 1   THR n 
2 2   ASN n 
2 3   LEU n 
2 4   CYS n 
2 5   PRO n 
2 6   PHE n 
2 7   ASP n 
2 8   GLU n 
2 9   VAL n 
2 10  PHE n 
2 11  ASN n 
2 12  ALA n 
2 13  THR n 
2 14  ARG n 
2 15  PHE n 
2 16  ALA n 
2 17  SER n 
2 18  VAL n 
2 19  TYR n 
2 20  ALA n 
2 21  TRP n 
2 22  ASN n 
2 23  ARG n 
2 24  LYS n 
2 25  ARG n 
2 26  ILE n 
2 27  SER n 
2 28  ASN n 
2 29  CYS n 
2 30  VAL n 
2 31  ALA n 
2 32  ASP n 
2 33  TYR n 
2 34  SER n 
2 35  VAL n 
2 36  LEU n 
2 37  TYR n 
2 38  ASN n 
2 39  PHE n 
2 40  ALA n 
2 41  PRO n 
2 42  PHE n 
2 43  SER n 
2 44  ALA n 
2 45  PHE n 
2 46  LYS n 
2 47  CYS n 
2 48  TYR n 
2 49  GLY n 
2 50  VAL n 
2 51  SER n 
2 52  PRO n 
2 53  THR n 
2 54  LYS n 
2 55  LEU n 
2 56  ASN n 
2 57  ASP n 
2 58  LEU n 
2 59  CYS n 
2 60  PHE n 
2 61  THR n 
2 62  ASN n 
2 63  VAL n 
2 64  TYR n 
2 65  ALA n 
2 66  ASP n 
2 67  SER n 
2 68  PHE n 
2 69  VAL n 
2 70  ILE n 
2 71  ARG n 
2 72  GLY n 
2 73  ASN n 
2 74  GLU n 
2 75  VAL n 
2 76  SER n 
2 77  GLN n 
2 78  ILE n 
2 79  ALA n 
2 80  PRO n 
2 81  GLY n 
2 82  GLN n 
2 83  THR n 
2 84  GLY n 
2 85  ASN n 
2 86  ILE n 
2 87  ALA n 
2 88  ASP n 
2 89  TYR n 
2 90  ASN n 
2 91  TYR n 
2 92  LYS n 
2 93  LEU n 
2 94  PRO n 
2 95  ASP n 
2 96  ASP n 
2 97  PHE n 
2 98  THR n 
2 99  GLY n 
2 100 CYS n 
2 101 VAL n 
2 102 ILE n 
2 103 ALA n 
2 104 TRP n 
2 105 ASN n 
2 106 SER n 
2 107 ASN n 
2 108 LYS n 
2 109 LEU n 
2 110 ASP n 
2 111 SER n 
2 112 LYS n 
2 113 VAL n 
2 114 GLY n 
2 115 GLY n 
2 116 ASN n 
2 117 TYR n 
2 118 ASN n 
2 119 TYR n 
2 120 ARG n 
2 121 TYR n 
2 122 ARG n 
2 123 LEU n 
2 124 PHE n 
2 125 ARG n 
2 126 LYS n 
2 127 SER n 
2 128 ASN n 
2 129 LEU n 
2 130 LYS n 
2 131 PRO n 
2 132 PHE n 
2 133 GLU n 
2 134 ARG n 
2 135 ASP n 
2 136 ILE n 
2 137 SER n 
2 138 THR n 
2 139 GLU n 
2 140 ILE n 
2 141 TYR n 
2 142 GLN n 
2 143 ALA n 
2 144 GLY n 
2 145 ASN n 
2 146 LYS n 
2 147 PRO n 
2 148 CYS n 
2 149 ASN n 
2 150 GLY n 
2 151 VAL n 
2 152 ALA n 
2 153 GLY n 
2 154 VAL n 
2 155 ASN n 
2 156 CYS n 
2 157 TYR n 
2 158 PHE n 
2 159 PRO n 
2 160 LEU n 
2 161 GLN n 
2 162 SER n 
2 163 TYR n 
2 164 GLY n 
2 165 PHE n 
2 166 ARG n 
2 167 PRO n 
2 168 THR n 
2 169 TYR n 
2 170 GLY n 
2 171 VAL n 
2 172 GLY n 
2 173 HIS n 
2 174 GLN n 
2 175 PRO n 
2 176 TYR n 
2 177 ARG n 
2 178 VAL n 
2 179 VAL n 
2 180 VAL n 
2 181 LEU n 
2 182 SER n 
2 183 PHE n 
2 184 GLU n 
2 185 LEU n 
2 186 LEU n 
2 187 HIS n 
2 188 ALA n 
2 189 PRO n 
2 190 ALA n 
2 191 THR n 
2 192 VAL n 
2 193 CYS n 
2 194 GLY n 
2 195 SER n 
2 196 ASN n 
2 197 SER n 
2 198 GLU n 
2 199 ASN n 
2 200 LEU n 
2 201 TYR n 
2 202 PHE n 
2 203 GLN n 
2 204 GLY n 
2 205 SER n 
2 206 HIS n 
2 207 HIS n 
2 208 HIS n 
2 209 HIS n 
2 210 HIS n 
2 211 HIS n 
2 212 HIS n 
2 213 HIS n 
2 214 HIS n 
2 215 HIS n 
2 216 GLY n 
2 217 LEU n 
2 218 ASN n 
2 219 ASP n 
2 220 ILE n 
2 221 PHE n 
2 222 GLU n 
2 223 ALA n 
2 224 GLN n 
2 225 LYS n 
2 226 ILE n 
2 227 GLU n 
2 228 TRP n 
2 229 HIS n 
2 230 GLU n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   230 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'S, 2' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               Expi293F 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       39 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   1   1   ASP ASP A . n 
A 1 2   LYS 2   2   2   LYS LYS A . n 
A 1 3   LEU 3   3   3   LEU LEU A . n 
A 1 4   TRP 4   4   4   TRP TRP A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  TYR 10  10  10  TYR TYR A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  MET 13  13  13  MET MET A . n 
A 1 14  VAL 14  14  14  VAL VAL A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  ASP 17  17  17  ASP ASP A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  HIS 21  21  21  HIS HIS A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  MET 27  27  27  MET MET A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  SER 29  29  29  SER SER A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  TYR 33  33  33  TYR TYR A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
B 2 1   THR 1   333 ?   ?   ?   B . n 
B 2 2   ASN 2   334 334 ASN ASN B . n 
B 2 3   LEU 3   335 335 LEU LEU B . n 
B 2 4   CYS 4   336 336 CYS CYS B . n 
B 2 5   PRO 5   337 337 PRO PRO B . n 
B 2 6   PHE 6   338 338 PHE PHE B . n 
B 2 7   ASP 7   339 339 ASP ASP B . n 
B 2 8   GLU 8   340 340 GLU GLU B . n 
B 2 9   VAL 9   341 341 VAL VAL B . n 
B 2 10  PHE 10  342 342 PHE PHE B . n 
B 2 11  ASN 11  343 343 ASN ASN B . n 
B 2 12  ALA 12  344 344 ALA ALA B . n 
B 2 13  THR 13  345 345 THR THR B . n 
B 2 14  ARG 14  346 346 ARG ARG B . n 
B 2 15  PHE 15  347 347 PHE PHE B . n 
B 2 16  ALA 16  348 348 ALA ALA B . n 
B 2 17  SER 17  349 349 SER SER B . n 
B 2 18  VAL 18  350 350 VAL VAL B . n 
B 2 19  TYR 19  351 351 TYR TYR B . n 
B 2 20  ALA 20  352 352 ALA ALA B . n 
B 2 21  TRP 21  353 353 TRP TRP B . n 
B 2 22  ASN 22  354 354 ASN ASN B . n 
B 2 23  ARG 23  355 355 ARG ARG B . n 
B 2 24  LYS 24  356 356 LYS LYS B . n 
B 2 25  ARG 25  357 357 ARG ARG B . n 
B 2 26  ILE 26  358 358 ILE ILE B . n 
B 2 27  SER 27  359 359 SER SER B . n 
B 2 28  ASN 28  360 360 ASN ASN B . n 
B 2 29  CYS 29  361 361 CYS CYS B . n 
B 2 30  VAL 30  362 362 VAL VAL B . n 
B 2 31  ALA 31  363 363 ALA ALA B . n 
B 2 32  ASP 32  364 364 ASP ASP B . n 
B 2 33  TYR 33  365 365 TYR TYR B . n 
B 2 34  SER 34  366 366 SER SER B . n 
B 2 35  VAL 35  367 367 VAL VAL B . n 
B 2 36  LEU 36  368 368 LEU LEU B . n 
B 2 37  TYR 37  369 369 TYR TYR B . n 
B 2 38  ASN 38  370 370 ASN ASN B . n 
B 2 39  PHE 39  371 371 PHE PHE B . n 
B 2 40  ALA 40  372 ?   ?   ?   B . n 
B 2 41  PRO 41  373 ?   ?   ?   B . n 
B 2 42  PHE 42  374 374 PHE PHE B . n 
B 2 43  SER 43  375 375 SER SER B . n 
B 2 44  ALA 44  376 376 ALA ALA B . n 
B 2 45  PHE 45  377 377 PHE PHE B . n 
B 2 46  LYS 46  378 378 LYS LYS B . n 
B 2 47  CYS 47  379 379 CYS CYS B . n 
B 2 48  TYR 48  380 380 TYR TYR B . n 
B 2 49  GLY 49  381 381 GLY GLY B . n 
B 2 50  VAL 50  382 382 VAL VAL B . n 
B 2 51  SER 51  383 383 SER SER B . n 
B 2 52  PRO 52  384 384 PRO PRO B . n 
B 2 53  THR 53  385 385 THR THR B . n 
B 2 54  LYS 54  386 386 LYS LYS B . n 
B 2 55  LEU 55  387 387 LEU LEU B . n 
B 2 56  ASN 56  388 388 ASN ASN B . n 
B 2 57  ASP 57  389 389 ASP ASP B . n 
B 2 58  LEU 58  390 390 LEU LEU B . n 
B 2 59  CYS 59  391 391 CYS CYS B . n 
B 2 60  PHE 60  392 392 PHE PHE B . n 
B 2 61  THR 61  393 393 THR THR B . n 
B 2 62  ASN 62  394 394 ASN ASN B . n 
B 2 63  VAL 63  395 395 VAL VAL B . n 
B 2 64  TYR 64  396 396 TYR TYR B . n 
B 2 65  ALA 65  397 397 ALA ALA B . n 
B 2 66  ASP 66  398 398 ASP ASP B . n 
B 2 67  SER 67  399 399 SER SER B . n 
B 2 68  PHE 68  400 400 PHE PHE B . n 
B 2 69  VAL 69  401 401 VAL VAL B . n 
B 2 70  ILE 70  402 402 ILE ILE B . n 
B 2 71  ARG 71  403 403 ARG ARG B . n 
B 2 72  GLY 72  404 404 GLY GLY B . n 
B 2 73  ASN 73  405 405 ASN ASN B . n 
B 2 74  GLU 74  406 406 GLU GLU B . n 
B 2 75  VAL 75  407 407 VAL VAL B . n 
B 2 76  SER 76  408 408 SER SER B . n 
B 2 77  GLN 77  409 409 GLN GLN B . n 
B 2 78  ILE 78  410 410 ILE ILE B . n 
B 2 79  ALA 79  411 411 ALA ALA B . n 
B 2 80  PRO 80  412 412 PRO PRO B . n 
B 2 81  GLY 81  413 413 GLY GLY B . n 
B 2 82  GLN 82  414 414 GLN GLN B . n 
B 2 83  THR 83  415 415 THR THR B . n 
B 2 84  GLY 84  416 416 GLY GLY B . n 
B 2 85  ASN 85  417 417 ASN ASN B . n 
B 2 86  ILE 86  418 418 ILE ILE B . n 
B 2 87  ALA 87  419 419 ALA ALA B . n 
B 2 88  ASP 88  420 420 ASP ASP B . n 
B 2 89  TYR 89  421 421 TYR TYR B . n 
B 2 90  ASN 90  422 422 ASN ASN B . n 
B 2 91  TYR 91  423 423 TYR TYR B . n 
B 2 92  LYS 92  424 424 LYS LYS B . n 
B 2 93  LEU 93  425 425 LEU LEU B . n 
B 2 94  PRO 94  426 426 PRO PRO B . n 
B 2 95  ASP 95  427 427 ASP ASP B . n 
B 2 96  ASP 96  428 428 ASP ASP B . n 
B 2 97  PHE 97  429 429 PHE PHE B . n 
B 2 98  THR 98  430 430 THR THR B . n 
B 2 99  GLY 99  431 431 GLY GLY B . n 
B 2 100 CYS 100 432 432 CYS CYS B . n 
B 2 101 VAL 101 433 433 VAL VAL B . n 
B 2 102 ILE 102 434 434 ILE ILE B . n 
B 2 103 ALA 103 435 435 ALA ALA B . n 
B 2 104 TRP 104 436 436 TRP TRP B . n 
B 2 105 ASN 105 437 437 ASN ASN B . n 
B 2 106 SER 106 438 438 SER SER B . n 
B 2 107 ASN 107 439 439 ASN ASN B . n 
B 2 108 LYS 108 440 440 LYS LYS B . n 
B 2 109 LEU 109 441 441 LEU LEU B . n 
B 2 110 ASP 110 442 442 ASP ASP B . n 
B 2 111 SER 111 443 443 SER SER B . n 
B 2 112 LYS 112 444 444 LYS LYS B . n 
B 2 113 VAL 113 445 445 VAL VAL B . n 
B 2 114 GLY 114 446 446 GLY GLY B . n 
B 2 115 GLY 115 447 447 GLY GLY B . n 
B 2 116 ASN 116 448 448 ASN ASN B . n 
B 2 117 TYR 117 449 449 TYR TYR B . n 
B 2 118 ASN 118 450 450 ASN ASN B . n 
B 2 119 TYR 119 451 451 TYR TYR B . n 
B 2 120 ARG 120 452 452 ARG ARG B . n 
B 2 121 TYR 121 453 453 TYR TYR B . n 
B 2 122 ARG 122 454 454 ARG ARG B . n 
B 2 123 LEU 123 455 455 LEU LEU B . n 
B 2 124 PHE 124 456 456 PHE PHE B . n 
B 2 125 ARG 125 457 457 ARG ARG B . n 
B 2 126 LYS 126 458 458 LYS LYS B . n 
B 2 127 SER 127 459 459 SER SER B . n 
B 2 128 ASN 128 460 460 ASN ASN B . n 
B 2 129 LEU 129 461 461 LEU LEU B . n 
B 2 130 LYS 130 462 462 LYS LYS B . n 
B 2 131 PRO 131 463 463 PRO PRO B . n 
B 2 132 PHE 132 464 464 PHE PHE B . n 
B 2 133 GLU 133 465 465 GLU GLU B . n 
B 2 134 ARG 134 466 466 ARG ARG B . n 
B 2 135 ASP 135 467 467 ASP ASP B . n 
B 2 136 ILE 136 468 468 ILE ILE B . n 
B 2 137 SER 137 469 469 SER SER B . n 
B 2 138 THR 138 470 470 THR THR B . n 
B 2 139 GLU 139 471 471 GLU GLU B . n 
B 2 140 ILE 140 472 472 ILE ILE B . n 
B 2 141 TYR 141 473 473 TYR TYR B . n 
B 2 142 GLN 142 474 474 GLN GLN B . n 
B 2 143 ALA 143 475 475 ALA ALA B . n 
B 2 144 GLY 144 476 476 GLY GLY B . n 
B 2 145 ASN 145 477 477 ASN ASN B . n 
B 2 146 LYS 146 478 478 LYS LYS B . n 
B 2 147 PRO 147 479 479 PRO PRO B . n 
B 2 148 CYS 148 480 480 CYS CYS B . n 
B 2 149 ASN 149 481 481 ASN ASN B . n 
B 2 150 GLY 150 482 482 GLY GLY B . n 
B 2 151 VAL 151 483 483 VAL VAL B . n 
B 2 152 ALA 152 484 484 ALA ALA B . n 
B 2 153 GLY 153 485 485 GLY GLY B . n 
B 2 154 VAL 154 486 486 VAL VAL B . n 
B 2 155 ASN 155 487 487 ASN ASN B . n 
B 2 156 CYS 156 488 488 CYS CYS B . n 
B 2 157 TYR 157 489 489 TYR TYR B . n 
B 2 158 PHE 158 490 490 PHE PHE B . n 
B 2 159 PRO 159 491 491 PRO PRO B . n 
B 2 160 LEU 160 492 492 LEU LEU B . n 
B 2 161 GLN 161 493 493 GLN GLN B . n 
B 2 162 SER 162 494 494 SER SER B . n 
B 2 163 TYR 163 495 495 TYR TYR B . n 
B 2 164 GLY 164 496 496 GLY GLY B . n 
B 2 165 PHE 165 497 497 PHE PHE B . n 
B 2 166 ARG 166 498 498 ARG ARG B . n 
B 2 167 PRO 167 499 499 PRO PRO B . n 
B 2 168 THR 168 500 500 THR THR B . n 
B 2 169 TYR 169 501 501 TYR TYR B . n 
B 2 170 GLY 170 502 502 GLY GLY B . n 
B 2 171 VAL 171 503 503 VAL VAL B . n 
B 2 172 GLY 172 504 504 GLY GLY B . n 
B 2 173 HIS 173 505 505 HIS HIS B . n 
B 2 174 GLN 174 506 506 GLN GLN B . n 
B 2 175 PRO 175 507 507 PRO PRO B . n 
B 2 176 TYR 176 508 508 TYR TYR B . n 
B 2 177 ARG 177 509 509 ARG ARG B . n 
B 2 178 VAL 178 510 510 VAL VAL B . n 
B 2 179 VAL 179 511 511 VAL VAL B . n 
B 2 180 VAL 180 512 512 VAL VAL B . n 
B 2 181 LEU 181 513 513 LEU LEU B . n 
B 2 182 SER 182 514 514 SER SER B . n 
B 2 183 PHE 183 515 515 PHE PHE B . n 
B 2 184 GLU 184 516 516 GLU GLU B . n 
B 2 185 LEU 185 517 517 LEU LEU B . n 
B 2 186 LEU 186 518 518 LEU LEU B . n 
B 2 187 HIS 187 519 519 HIS HIS B . n 
B 2 188 ALA 188 520 520 ALA ALA B . n 
B 2 189 PRO 189 521 521 PRO PRO B . n 
B 2 190 ALA 190 522 522 ALA ALA B . n 
B 2 191 THR 191 523 523 THR THR B . n 
B 2 192 VAL 192 524 524 VAL VAL B . n 
B 2 193 CYS 193 525 525 CYS CYS B . n 
B 2 194 GLY 194 526 526 GLY GLY B . n 
B 2 195 SER 195 527 527 SER SER B . n 
B 2 196 ASN 196 528 528 ASN ASN B . n 
B 2 197 SER 197 529 529 SER SER B . n 
B 2 198 GLU 198 530 ?   ?   ?   B . n 
B 2 199 ASN 199 531 ?   ?   ?   B . n 
B 2 200 LEU 200 532 ?   ?   ?   B . n 
B 2 201 TYR 201 533 ?   ?   ?   B . n 
B 2 202 PHE 202 534 ?   ?   ?   B . n 
B 2 203 GLN 203 535 ?   ?   ?   B . n 
B 2 204 GLY 204 536 ?   ?   ?   B . n 
B 2 205 SER 205 537 ?   ?   ?   B . n 
B 2 206 HIS 206 538 ?   ?   ?   B . n 
B 2 207 HIS 207 539 ?   ?   ?   B . n 
B 2 208 HIS 208 540 ?   ?   ?   B . n 
B 2 209 HIS 209 541 ?   ?   ?   B . n 
B 2 210 HIS 210 542 ?   ?   ?   B . n 
B 2 211 HIS 211 543 ?   ?   ?   B . n 
B 2 212 HIS 212 544 ?   ?   ?   B . n 
B 2 213 HIS 213 545 ?   ?   ?   B . n 
B 2 214 HIS 214 546 ?   ?   ?   B . n 
B 2 215 HIS 215 547 ?   ?   ?   B . n 
B 2 216 GLY 216 548 ?   ?   ?   B . n 
B 2 217 LEU 217 549 ?   ?   ?   B . n 
B 2 218 ASN 218 550 ?   ?   ?   B . n 
B 2 219 ASP 219 551 ?   ?   ?   B . n 
B 2 220 ILE 220 552 ?   ?   ?   B . n 
B 2 221 PHE 221 553 ?   ?   ?   B . n 
B 2 222 GLU 222 554 ?   ?   ?   B . n 
B 2 223 ALA 223 555 ?   ?   ?   B . n 
B 2 224 GLN 224 556 ?   ?   ?   B . n 
B 2 225 LYS 225 557 ?   ?   ?   B . n 
B 2 226 ILE 226 558 ?   ?   ?   B . n 
B 2 227 GLU 227 559 ?   ?   ?   B . n 
B 2 228 TRP 228 560 ?   ?   ?   B . n 
B 2 229 HIS 229 561 ?   ?   ?   B . n 
B 2 230 GLU 230 562 ?   ?   ?   B . n 
C 1 1   ASP 1   1   1   ASP ASP C . n 
C 1 2   LYS 2   2   2   LYS LYS C . n 
C 1 3   LEU 3   3   3   LEU LEU C . n 
C 1 4   TRP 4   4   4   TRP TRP C . n 
C 1 5   ILE 5   5   5   ILE ILE C . n 
C 1 6   LEU 6   6   6   LEU LEU C . n 
C 1 7   GLN 7   7   7   GLN GLN C . n 
C 1 8   LYS 8   8   8   LYS LYS C . n 
C 1 9   ILE 9   9   9   ILE ILE C . n 
C 1 10  TYR 10  10  10  TYR TYR C . n 
C 1 11  GLU 11  11  11  GLU GLU C . n 
C 1 12  ILE 12  12  12  ILE ILE C . n 
C 1 13  MET 13  13  13  MET MET C . n 
C 1 14  VAL 14  14  14  VAL VAL C . n 
C 1 15  ARG 15  15  15  ARG ARG C . n 
C 1 16  LEU 16  16  16  LEU LEU C . n 
C 1 17  ASP 17  17  17  ASP ASP C . n 
C 1 18  GLU 18  18  18  GLU GLU C . n 
C 1 19  GLU 19  19  19  GLU GLU C . n 
C 1 20  GLY 20  20  20  GLY GLY C . n 
C 1 21  HIS 21  21  21  HIS HIS C . n 
C 1 22  GLY 22  22  22  GLY GLY C . n 
C 1 23  GLU 23  23  23  GLU GLU C . n 
C 1 24  ALA 24  24  24  ALA ALA C . n 
C 1 25  SER 25  25  25  SER SER C . n 
C 1 26  LEU 26  26  26  LEU LEU C . n 
C 1 27  MET 27  27  27  MET MET C . n 
C 1 28  VAL 28  28  28  VAL VAL C . n 
C 1 29  SER 29  29  29  SER SER C . n 
C 1 30  ASP 30  30  30  ASP ASP C . n 
C 1 31  LEU 31  31  31  LEU LEU C . n 
C 1 32  ILE 32  32  32  ILE ILE C . n 
C 1 33  TYR 33  33  33  TYR TYR C . n 
C 1 34  GLU 34  34  34  GLU GLU C . n 
C 1 35  PHE 35  35  35  PHE PHE C . n 
C 1 36  MET 36  36  36  MET MET C . n 
C 1 37  LYS 37  37  37  LYS LYS C . n 
C 1 38  ARG 38  38  38  ARG ARG C . n 
C 1 39  ASP 39  39  39  ASP ASP C . n 
D 2 1   THR 1   333 333 THR THR D . n 
D 2 2   ASN 2   334 334 ASN ASN D . n 
D 2 3   LEU 3   335 335 LEU LEU D . n 
D 2 4   CYS 4   336 336 CYS CYS D . n 
D 2 5   PRO 5   337 337 PRO PRO D . n 
D 2 6   PHE 6   338 338 PHE PHE D . n 
D 2 7   ASP 7   339 339 ASP ASP D . n 
D 2 8   GLU 8   340 340 GLU GLU D . n 
D 2 9   VAL 9   341 341 VAL VAL D . n 
D 2 10  PHE 10  342 342 PHE PHE D . n 
D 2 11  ASN 11  343 343 ASN ASN D . n 
D 2 12  ALA 12  344 344 ALA ALA D . n 
D 2 13  THR 13  345 345 THR THR D . n 
D 2 14  ARG 14  346 346 ARG ARG D . n 
D 2 15  PHE 15  347 347 PHE PHE D . n 
D 2 16  ALA 16  348 348 ALA ALA D . n 
D 2 17  SER 17  349 349 SER SER D . n 
D 2 18  VAL 18  350 350 VAL VAL D . n 
D 2 19  TYR 19  351 351 TYR TYR D . n 
D 2 20  ALA 20  352 352 ALA ALA D . n 
D 2 21  TRP 21  353 353 TRP TRP D . n 
D 2 22  ASN 22  354 354 ASN ASN D . n 
D 2 23  ARG 23  355 355 ARG ARG D . n 
D 2 24  LYS 24  356 356 LYS LYS D . n 
D 2 25  ARG 25  357 357 ARG ARG D . n 
D 2 26  ILE 26  358 358 ILE ILE D . n 
D 2 27  SER 27  359 359 SER SER D . n 
D 2 28  ASN 28  360 360 ASN ASN D . n 
D 2 29  CYS 29  361 361 CYS CYS D . n 
D 2 30  VAL 30  362 362 VAL VAL D . n 
D 2 31  ALA 31  363 363 ALA ALA D . n 
D 2 32  ASP 32  364 364 ASP ASP D . n 
D 2 33  TYR 33  365 365 TYR TYR D . n 
D 2 34  SER 34  366 366 SER SER D . n 
D 2 35  VAL 35  367 367 VAL VAL D . n 
D 2 36  LEU 36  368 368 LEU LEU D . n 
D 2 37  TYR 37  369 369 TYR TYR D . n 
D 2 38  ASN 38  370 370 ASN ASN D . n 
D 2 39  PHE 39  371 371 PHE PHE D . n 
D 2 40  ALA 40  372 372 ALA ALA D . n 
D 2 41  PRO 41  373 373 PRO PRO D . n 
D 2 42  PHE 42  374 374 PHE PHE D . n 
D 2 43  SER 43  375 375 SER SER D . n 
D 2 44  ALA 44  376 376 ALA ALA D . n 
D 2 45  PHE 45  377 377 PHE PHE D . n 
D 2 46  LYS 46  378 378 LYS LYS D . n 
D 2 47  CYS 47  379 379 CYS CYS D . n 
D 2 48  TYR 48  380 380 TYR TYR D . n 
D 2 49  GLY 49  381 381 GLY GLY D . n 
D 2 50  VAL 50  382 382 VAL VAL D . n 
D 2 51  SER 51  383 383 SER SER D . n 
D 2 52  PRO 52  384 384 PRO PRO D . n 
D 2 53  THR 53  385 385 THR THR D . n 
D 2 54  LYS 54  386 386 LYS LYS D . n 
D 2 55  LEU 55  387 387 LEU LEU D . n 
D 2 56  ASN 56  388 388 ASN ASN D . n 
D 2 57  ASP 57  389 389 ASP ASP D . n 
D 2 58  LEU 58  390 390 LEU LEU D . n 
D 2 59  CYS 59  391 391 CYS CYS D . n 
D 2 60  PHE 60  392 392 PHE PHE D . n 
D 2 61  THR 61  393 393 THR THR D . n 
D 2 62  ASN 62  394 394 ASN ASN D . n 
D 2 63  VAL 63  395 395 VAL VAL D . n 
D 2 64  TYR 64  396 396 TYR TYR D . n 
D 2 65  ALA 65  397 397 ALA ALA D . n 
D 2 66  ASP 66  398 398 ASP ASP D . n 
D 2 67  SER 67  399 399 SER SER D . n 
D 2 68  PHE 68  400 400 PHE PHE D . n 
D 2 69  VAL 69  401 401 VAL VAL D . n 
D 2 70  ILE 70  402 402 ILE ILE D . n 
D 2 71  ARG 71  403 403 ARG ARG D . n 
D 2 72  GLY 72  404 404 GLY GLY D . n 
D 2 73  ASN 73  405 405 ASN ASN D . n 
D 2 74  GLU 74  406 406 GLU GLU D . n 
D 2 75  VAL 75  407 407 VAL VAL D . n 
D 2 76  SER 76  408 408 SER SER D . n 
D 2 77  GLN 77  409 409 GLN GLN D . n 
D 2 78  ILE 78  410 410 ILE ILE D . n 
D 2 79  ALA 79  411 411 ALA ALA D . n 
D 2 80  PRO 80  412 412 PRO PRO D . n 
D 2 81  GLY 81  413 413 GLY GLY D . n 
D 2 82  GLN 82  414 414 GLN GLN D . n 
D 2 83  THR 83  415 415 THR THR D . n 
D 2 84  GLY 84  416 416 GLY GLY D . n 
D 2 85  ASN 85  417 417 ASN ASN D . n 
D 2 86  ILE 86  418 418 ILE ILE D . n 
D 2 87  ALA 87  419 419 ALA ALA D . n 
D 2 88  ASP 88  420 420 ASP ASP D . n 
D 2 89  TYR 89  421 421 TYR TYR D . n 
D 2 90  ASN 90  422 422 ASN ASN D . n 
D 2 91  TYR 91  423 423 TYR TYR D . n 
D 2 92  LYS 92  424 424 LYS LYS D . n 
D 2 93  LEU 93  425 425 LEU LEU D . n 
D 2 94  PRO 94  426 426 PRO PRO D . n 
D 2 95  ASP 95  427 427 ASP ASP D . n 
D 2 96  ASP 96  428 428 ASP ASP D . n 
D 2 97  PHE 97  429 429 PHE PHE D . n 
D 2 98  THR 98  430 430 THR THR D . n 
D 2 99  GLY 99  431 431 GLY GLY D . n 
D 2 100 CYS 100 432 432 CYS CYS D . n 
D 2 101 VAL 101 433 433 VAL VAL D . n 
D 2 102 ILE 102 434 434 ILE ILE D . n 
D 2 103 ALA 103 435 435 ALA ALA D . n 
D 2 104 TRP 104 436 436 TRP TRP D . n 
D 2 105 ASN 105 437 437 ASN ASN D . n 
D 2 106 SER 106 438 438 SER SER D . n 
D 2 107 ASN 107 439 439 ASN ASN D . n 
D 2 108 LYS 108 440 440 LYS LYS D . n 
D 2 109 LEU 109 441 441 LEU LEU D . n 
D 2 110 ASP 110 442 442 ASP ASP D . n 
D 2 111 SER 111 443 443 SER SER D . n 
D 2 112 LYS 112 444 444 LYS LYS D . n 
D 2 113 VAL 113 445 445 VAL VAL D . n 
D 2 114 GLY 114 446 446 GLY GLY D . n 
D 2 115 GLY 115 447 447 GLY GLY D . n 
D 2 116 ASN 116 448 448 ASN ASN D . n 
D 2 117 TYR 117 449 449 TYR TYR D . n 
D 2 118 ASN 118 450 450 ASN ASN D . n 
D 2 119 TYR 119 451 451 TYR TYR D . n 
D 2 120 ARG 120 452 452 ARG ARG D . n 
D 2 121 TYR 121 453 453 TYR TYR D . n 
D 2 122 ARG 122 454 454 ARG ARG D . n 
D 2 123 LEU 123 455 455 LEU LEU D . n 
D 2 124 PHE 124 456 456 PHE PHE D . n 
D 2 125 ARG 125 457 457 ARG ARG D . n 
D 2 126 LYS 126 458 458 LYS LYS D . n 
D 2 127 SER 127 459 459 SER SER D . n 
D 2 128 ASN 128 460 460 ASN ASN D . n 
D 2 129 LEU 129 461 461 LEU LEU D . n 
D 2 130 LYS 130 462 462 LYS LYS D . n 
D 2 131 PRO 131 463 463 PRO PRO D . n 
D 2 132 PHE 132 464 464 PHE PHE D . n 
D 2 133 GLU 133 465 465 GLU GLU D . n 
D 2 134 ARG 134 466 466 ARG ARG D . n 
D 2 135 ASP 135 467 467 ASP ASP D . n 
D 2 136 ILE 136 468 468 ILE ILE D . n 
D 2 137 SER 137 469 469 SER SER D . n 
D 2 138 THR 138 470 470 THR THR D . n 
D 2 139 GLU 139 471 471 GLU GLU D . n 
D 2 140 ILE 140 472 472 ILE ILE D . n 
D 2 141 TYR 141 473 473 TYR TYR D . n 
D 2 142 GLN 142 474 474 GLN GLN D . n 
D 2 143 ALA 143 475 475 ALA ALA D . n 
D 2 144 GLY 144 476 476 GLY GLY D . n 
D 2 145 ASN 145 477 477 ASN ASN D . n 
D 2 146 LYS 146 478 478 LYS LYS D . n 
D 2 147 PRO 147 479 479 PRO PRO D . n 
D 2 148 CYS 148 480 480 CYS CYS D . n 
D 2 149 ASN 149 481 481 ASN ASN D . n 
D 2 150 GLY 150 482 482 GLY GLY D . n 
D 2 151 VAL 151 483 483 VAL VAL D . n 
D 2 152 ALA 152 484 484 ALA ALA D . n 
D 2 153 GLY 153 485 485 GLY GLY D . n 
D 2 154 VAL 154 486 486 VAL VAL D . n 
D 2 155 ASN 155 487 487 ASN ASN D . n 
D 2 156 CYS 156 488 488 CYS CYS D . n 
D 2 157 TYR 157 489 489 TYR TYR D . n 
D 2 158 PHE 158 490 490 PHE PHE D . n 
D 2 159 PRO 159 491 491 PRO PRO D . n 
D 2 160 LEU 160 492 492 LEU LEU D . n 
D 2 161 GLN 161 493 493 GLN GLN D . n 
D 2 162 SER 162 494 494 SER SER D . n 
D 2 163 TYR 163 495 495 TYR TYR D . n 
D 2 164 GLY 164 496 496 GLY GLY D . n 
D 2 165 PHE 165 497 497 PHE PHE D . n 
D 2 166 ARG 166 498 498 ARG ARG D . n 
D 2 167 PRO 167 499 499 PRO PRO D . n 
D 2 168 THR 168 500 500 THR THR D . n 
D 2 169 TYR 169 501 501 TYR TYR D . n 
D 2 170 GLY 170 502 502 GLY GLY D . n 
D 2 171 VAL 171 503 503 VAL VAL D . n 
D 2 172 GLY 172 504 504 GLY GLY D . n 
D 2 173 HIS 173 505 505 HIS HIS D . n 
D 2 174 GLN 174 506 506 GLN GLN D . n 
D 2 175 PRO 175 507 507 PRO PRO D . n 
D 2 176 TYR 176 508 508 TYR TYR D . n 
D 2 177 ARG 177 509 509 ARG ARG D . n 
D 2 178 VAL 178 510 510 VAL VAL D . n 
D 2 179 VAL 179 511 511 VAL VAL D . n 
D 2 180 VAL 180 512 512 VAL VAL D . n 
D 2 181 LEU 181 513 513 LEU LEU D . n 
D 2 182 SER 182 514 514 SER SER D . n 
D 2 183 PHE 183 515 515 PHE PHE D . n 
D 2 184 GLU 184 516 516 GLU GLU D . n 
D 2 185 LEU 185 517 517 LEU LEU D . n 
D 2 186 LEU 186 518 518 LEU LEU D . n 
D 2 187 HIS 187 519 519 HIS HIS D . n 
D 2 188 ALA 188 520 520 ALA ALA D . n 
D 2 189 PRO 189 521 521 PRO PRO D . n 
D 2 190 ALA 190 522 522 ALA ALA D . n 
D 2 191 THR 191 523 523 THR THR D . n 
D 2 192 VAL 192 524 524 VAL VAL D . n 
D 2 193 CYS 193 525 525 CYS CYS D . n 
D 2 194 GLY 194 526 526 GLY GLY D . n 
D 2 195 SER 195 527 527 SER SER D . n 
D 2 196 ASN 196 528 528 ASN ASN D . n 
D 2 197 SER 197 529 529 SER SER D . n 
D 2 198 GLU 198 530 530 GLU GLU D . n 
D 2 199 ASN 199 531 ?   ?   ?   D . n 
D 2 200 LEU 200 532 ?   ?   ?   D . n 
D 2 201 TYR 201 533 ?   ?   ?   D . n 
D 2 202 PHE 202 534 ?   ?   ?   D . n 
D 2 203 GLN 203 535 ?   ?   ?   D . n 
D 2 204 GLY 204 536 ?   ?   ?   D . n 
D 2 205 SER 205 537 ?   ?   ?   D . n 
D 2 206 HIS 206 538 ?   ?   ?   D . n 
D 2 207 HIS 207 539 ?   ?   ?   D . n 
D 2 208 HIS 208 540 ?   ?   ?   D . n 
D 2 209 HIS 209 541 ?   ?   ?   D . n 
D 2 210 HIS 210 542 ?   ?   ?   D . n 
D 2 211 HIS 211 543 ?   ?   ?   D . n 
D 2 212 HIS 212 544 ?   ?   ?   D . n 
D 2 213 HIS 213 545 ?   ?   ?   D . n 
D 2 214 HIS 214 546 ?   ?   ?   D . n 
D 2 215 HIS 215 547 ?   ?   ?   D . n 
D 2 216 GLY 216 548 ?   ?   ?   D . n 
D 2 217 LEU 217 549 ?   ?   ?   D . n 
D 2 218 ASN 218 550 ?   ?   ?   D . n 
D 2 219 ASP 219 551 ?   ?   ?   D . n 
D 2 220 ILE 220 552 ?   ?   ?   D . n 
D 2 221 PHE 221 553 ?   ?   ?   D . n 
D 2 222 GLU 222 554 ?   ?   ?   D . n 
D 2 223 ALA 223 555 ?   ?   ?   D . n 
D 2 224 GLN 224 556 ?   ?   ?   D . n 
D 2 225 LYS 225 557 ?   ?   ?   D . n 
D 2 226 ILE 226 558 ?   ?   ?   D . n 
D 2 227 GLU 227 559 ?   ?   ?   D . n 
D 2 228 TRP 228 560 ?   ?   ?   D . n 
D 2 229 HIS 229 561 ?   ?   ?   D . n 
D 2 230 GLU 230 562 ?   ?   ?   D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 GOL 1   601 601 GOL GOL B . 
F 3 GOL 1   602 602 GOL GOL B . 
G 3 GOL 1   101 101 GOL GOL C . 
H 3 GOL 1   102 601 GOL GOL C . 
I 3 GOL 1   601 603 GOL GOL D . 
J 3 GOL 1   602 604 GOL GOL D . 
K 3 GOL 1   603 605 GOL GOL D . 
L 3 GOL 1   604 607 GOL GOL D . 
M 3 GOL 1   605 608 GOL GOL D . 
N 4 HOH 1   101 343 HOH HOH A . 
N 4 HOH 2   102 319 HOH HOH A . 
N 4 HOH 3   103 16  HOH HOH A . 
N 4 HOH 4   104 189 HOH HOH A . 
N 4 HOH 5   105 148 HOH HOH A . 
N 4 HOH 6   106 126 HOH HOH A . 
N 4 HOH 7   107 200 HOH HOH A . 
N 4 HOH 8   108 194 HOH HOH A . 
N 4 HOH 9   109 39  HOH HOH A . 
N 4 HOH 10  110 54  HOH HOH A . 
N 4 HOH 11  111 310 HOH HOH A . 
N 4 HOH 12  112 5   HOH HOH A . 
N 4 HOH 13  113 89  HOH HOH A . 
N 4 HOH 14  114 294 HOH HOH A . 
N 4 HOH 15  115 41  HOH HOH A . 
N 4 HOH 16  116 71  HOH HOH A . 
N 4 HOH 17  117 246 HOH HOH A . 
N 4 HOH 18  118 295 HOH HOH A . 
N 4 HOH 19  119 248 HOH HOH A . 
N 4 HOH 20  120 114 HOH HOH A . 
N 4 HOH 21  121 340 HOH HOH A . 
N 4 HOH 22  122 184 HOH HOH A . 
N 4 HOH 23  123 239 HOH HOH A . 
N 4 HOH 24  124 167 HOH HOH A . 
N 4 HOH 25  125 183 HOH HOH A . 
N 4 HOH 26  126 68  HOH HOH A . 
N 4 HOH 27  127 191 HOH HOH A . 
N 4 HOH 28  128 128 HOH HOH A . 
N 4 HOH 29  129 93  HOH HOH A . 
N 4 HOH 30  130 132 HOH HOH A . 
N 4 HOH 31  131 186 HOH HOH A . 
O 4 HOH 1   701 314 HOH HOH B . 
O 4 HOH 2   702 160 HOH HOH B . 
O 4 HOH 3   703 9   HOH HOH B . 
O 4 HOH 4   704 139 HOH HOH B . 
O 4 HOH 5   705 7   HOH HOH B . 
O 4 HOH 6   706 271 HOH HOH B . 
O 4 HOH 7   707 144 HOH HOH B . 
O 4 HOH 8   708 80  HOH HOH B . 
O 4 HOH 9   709 61  HOH HOH B . 
O 4 HOH 10  710 100 HOH HOH B . 
O 4 HOH 11  711 63  HOH HOH B . 
O 4 HOH 12  712 99  HOH HOH B . 
O 4 HOH 13  713 67  HOH HOH B . 
O 4 HOH 14  714 147 HOH HOH B . 
O 4 HOH 15  715 38  HOH HOH B . 
O 4 HOH 16  716 169 HOH HOH B . 
O 4 HOH 17  717 66  HOH HOH B . 
O 4 HOH 18  718 276 HOH HOH B . 
O 4 HOH 19  719 136 HOH HOH B . 
O 4 HOH 20  720 123 HOH HOH B . 
O 4 HOH 21  721 122 HOH HOH B . 
O 4 HOH 22  722 178 HOH HOH B . 
O 4 HOH 23  723 142 HOH HOH B . 
O 4 HOH 24  724 84  HOH HOH B . 
O 4 HOH 25  725 179 HOH HOH B . 
O 4 HOH 26  726 182 HOH HOH B . 
O 4 HOH 27  727 331 HOH HOH B . 
O 4 HOH 28  728 6   HOH HOH B . 
O 4 HOH 29  729 229 HOH HOH B . 
O 4 HOH 30  730 335 HOH HOH B . 
O 4 HOH 31  731 62  HOH HOH B . 
O 4 HOH 32  732 153 HOH HOH B . 
O 4 HOH 33  733 65  HOH HOH B . 
O 4 HOH 34  734 79  HOH HOH B . 
O 4 HOH 35  735 55  HOH HOH B . 
O 4 HOH 36  736 313 HOH HOH B . 
O 4 HOH 37  737 235 HOH HOH B . 
O 4 HOH 38  738 124 HOH HOH B . 
O 4 HOH 39  739 262 HOH HOH B . 
O 4 HOH 40  740 145 HOH HOH B . 
O 4 HOH 41  741 320 HOH HOH B . 
O 4 HOH 42  742 10  HOH HOH B . 
O 4 HOH 43  743 34  HOH HOH B . 
O 4 HOH 44  744 14  HOH HOH B . 
O 4 HOH 45  745 35  HOH HOH B . 
O 4 HOH 46  746 134 HOH HOH B . 
O 4 HOH 47  747 76  HOH HOH B . 
O 4 HOH 48  748 2   HOH HOH B . 
O 4 HOH 49  749 137 HOH HOH B . 
O 4 HOH 50  750 104 HOH HOH B . 
O 4 HOH 51  751 141 HOH HOH B . 
O 4 HOH 52  752 270 HOH HOH B . 
O 4 HOH 53  753 81  HOH HOH B . 
O 4 HOH 54  754 102 HOH HOH B . 
O 4 HOH 55  755 90  HOH HOH B . 
O 4 HOH 56  756 27  HOH HOH B . 
O 4 HOH 57  757 214 HOH HOH B . 
O 4 HOH 58  758 293 HOH HOH B . 
O 4 HOH 59  759 345 HOH HOH B . 
O 4 HOH 60  760 259 HOH HOH B . 
O 4 HOH 61  761 43  HOH HOH B . 
O 4 HOH 62  762 113 HOH HOH B . 
O 4 HOH 63  763 339 HOH HOH B . 
O 4 HOH 64  764 158 HOH HOH B . 
O 4 HOH 65  765 70  HOH HOH B . 
O 4 HOH 66  766 86  HOH HOH B . 
O 4 HOH 67  767 190 HOH HOH B . 
O 4 HOH 68  768 50  HOH HOH B . 
O 4 HOH 69  769 56  HOH HOH B . 
O 4 HOH 70  770 82  HOH HOH B . 
O 4 HOH 71  771 119 HOH HOH B . 
O 4 HOH 72  772 175 HOH HOH B . 
O 4 HOH 73  773 332 HOH HOH B . 
O 4 HOH 74  774 265 HOH HOH B . 
O 4 HOH 75  775 173 HOH HOH B . 
O 4 HOH 76  776 217 HOH HOH B . 
O 4 HOH 77  777 318 HOH HOH B . 
O 4 HOH 78  778 75  HOH HOH B . 
O 4 HOH 79  779 129 HOH HOH B . 
O 4 HOH 80  780 203 HOH HOH B . 
O 4 HOH 81  781 180 HOH HOH B . 
O 4 HOH 82  782 98  HOH HOH B . 
O 4 HOH 83  783 256 HOH HOH B . 
O 4 HOH 84  784 25  HOH HOH B . 
O 4 HOH 85  785 78  HOH HOH B . 
O 4 HOH 86  786 204 HOH HOH B . 
O 4 HOH 87  787 87  HOH HOH B . 
O 4 HOH 88  788 174 HOH HOH B . 
O 4 HOH 89  789 250 HOH HOH B . 
O 4 HOH 90  790 231 HOH HOH B . 
O 4 HOH 91  791 202 HOH HOH B . 
O 4 HOH 92  792 161 HOH HOH B . 
O 4 HOH 93  793 286 HOH HOH B . 
O 4 HOH 94  794 292 HOH HOH B . 
O 4 HOH 95  795 26  HOH HOH B . 
O 4 HOH 96  796 21  HOH HOH B . 
O 4 HOH 97  797 83  HOH HOH B . 
O 4 HOH 98  798 143 HOH HOH B . 
O 4 HOH 99  799 51  HOH HOH B . 
O 4 HOH 100 800 260 HOH HOH B . 
O 4 HOH 101 801 297 HOH HOH B . 
O 4 HOH 102 802 291 HOH HOH B . 
O 4 HOH 103 803 309 HOH HOH B . 
O 4 HOH 104 804 268 HOH HOH B . 
O 4 HOH 105 805 208 HOH HOH B . 
O 4 HOH 106 806 140 HOH HOH B . 
O 4 HOH 107 807 242 HOH HOH B . 
O 4 HOH 108 808 74  HOH HOH B . 
O 4 HOH 109 809 111 HOH HOH B . 
O 4 HOH 110 810 130 HOH HOH B . 
O 4 HOH 111 811 170 HOH HOH B . 
O 4 HOH 112 812 92  HOH HOH B . 
O 4 HOH 113 813 285 HOH HOH B . 
O 4 HOH 114 814 72  HOH HOH B . 
O 4 HOH 115 815 316 HOH HOH B . 
O 4 HOH 116 816 44  HOH HOH B . 
O 4 HOH 117 817 240 HOH HOH B . 
O 4 HOH 118 818 69  HOH HOH B . 
O 4 HOH 119 819 330 HOH HOH B . 
O 4 HOH 120 820 273 HOH HOH B . 
O 4 HOH 121 821 103 HOH HOH B . 
P 4 HOH 1   201 157 HOH HOH C . 
P 4 HOH 2   202 52  HOH HOH C . 
P 4 HOH 3   203 269 HOH HOH C . 
P 4 HOH 4   204 1   HOH HOH C . 
P 4 HOH 5   205 22  HOH HOH C . 
P 4 HOH 6   206 226 HOH HOH C . 
P 4 HOH 7   207 166 HOH HOH C . 
P 4 HOH 8   208 193 HOH HOH C . 
P 4 HOH 9   209 220 HOH HOH C . 
P 4 HOH 10  210 31  HOH HOH C . 
P 4 HOH 11  211 207 HOH HOH C . 
P 4 HOH 12  212 241 HOH HOH C . 
P 4 HOH 13  213 156 HOH HOH C . 
P 4 HOH 14  214 150 HOH HOH C . 
P 4 HOH 15  215 131 HOH HOH C . 
P 4 HOH 16  216 40  HOH HOH C . 
P 4 HOH 17  217 121 HOH HOH C . 
P 4 HOH 18  218 267 HOH HOH C . 
P 4 HOH 19  219 238 HOH HOH C . 
P 4 HOH 20  220 230 HOH HOH C . 
P 4 HOH 21  221 312 HOH HOH C . 
P 4 HOH 22  222 233 HOH HOH C . 
P 4 HOH 23  223 247 HOH HOH C . 
P 4 HOH 24  224 162 HOH HOH C . 
P 4 HOH 25  225 224 HOH HOH C . 
Q 4 HOH 1   701 306 HOH HOH D . 
Q 4 HOH 2   702 304 HOH HOH D . 
Q 4 HOH 3   703 185 HOH HOH D . 
Q 4 HOH 4   704 303 HOH HOH D . 
Q 4 HOH 5   705 152 HOH HOH D . 
Q 4 HOH 6   706 232 HOH HOH D . 
Q 4 HOH 7   707 328 HOH HOH D . 
Q 4 HOH 8   708 60  HOH HOH D . 
Q 4 HOH 9   709 116 HOH HOH D . 
Q 4 HOH 10  710 127 HOH HOH D . 
Q 4 HOH 11  711 53  HOH HOH D . 
Q 4 HOH 12  712 263 HOH HOH D . 
Q 4 HOH 13  713 88  HOH HOH D . 
Q 4 HOH 14  714 108 HOH HOH D . 
Q 4 HOH 15  715 37  HOH HOH D . 
Q 4 HOH 16  716 13  HOH HOH D . 
Q 4 HOH 17  717 251 HOH HOH D . 
Q 4 HOH 18  718 11  HOH HOH D . 
Q 4 HOH 19  719 338 HOH HOH D . 
Q 4 HOH 20  720 20  HOH HOH D . 
Q 4 HOH 21  721 165 HOH HOH D . 
Q 4 HOH 22  722 106 HOH HOH D . 
Q 4 HOH 23  723 266 HOH HOH D . 
Q 4 HOH 24  724 73  HOH HOH D . 
Q 4 HOH 25  725 149 HOH HOH D . 
Q 4 HOH 26  726 36  HOH HOH D . 
Q 4 HOH 27  727 12  HOH HOH D . 
Q 4 HOH 28  728 177 HOH HOH D . 
Q 4 HOH 29  729 23  HOH HOH D . 
Q 4 HOH 30  730 64  HOH HOH D . 
Q 4 HOH 31  731 155 HOH HOH D . 
Q 4 HOH 32  732 3   HOH HOH D . 
Q 4 HOH 33  733 18  HOH HOH D . 
Q 4 HOH 34  734 163 HOH HOH D . 
Q 4 HOH 35  735 19  HOH HOH D . 
Q 4 HOH 36  736 96  HOH HOH D . 
Q 4 HOH 37  737 30  HOH HOH D . 
Q 4 HOH 38  738 29  HOH HOH D . 
Q 4 HOH 39  739 17  HOH HOH D . 
Q 4 HOH 40  740 288 HOH HOH D . 
Q 4 HOH 41  741 151 HOH HOH D . 
Q 4 HOH 42  742 57  HOH HOH D . 
Q 4 HOH 43  743 168 HOH HOH D . 
Q 4 HOH 44  744 94  HOH HOH D . 
Q 4 HOH 45  745 48  HOH HOH D . 
Q 4 HOH 46  746 120 HOH HOH D . 
Q 4 HOH 47  747 329 HOH HOH D . 
Q 4 HOH 48  748 49  HOH HOH D . 
Q 4 HOH 49  749 8   HOH HOH D . 
Q 4 HOH 50  750 336 HOH HOH D . 
Q 4 HOH 51  751 15  HOH HOH D . 
Q 4 HOH 52  752 4   HOH HOH D . 
Q 4 HOH 53  753 24  HOH HOH D . 
Q 4 HOH 54  754 85  HOH HOH D . 
Q 4 HOH 55  755 112 HOH HOH D . 
Q 4 HOH 56  756 59  HOH HOH D . 
Q 4 HOH 57  757 341 HOH HOH D . 
Q 4 HOH 58  758 97  HOH HOH D . 
Q 4 HOH 59  759 32  HOH HOH D . 
Q 4 HOH 60  760 154 HOH HOH D . 
Q 4 HOH 61  761 135 HOH HOH D . 
Q 4 HOH 62  762 77  HOH HOH D . 
Q 4 HOH 63  763 159 HOH HOH D . 
Q 4 HOH 64  764 117 HOH HOH D . 
Q 4 HOH 65  765 118 HOH HOH D . 
Q 4 HOH 66  766 115 HOH HOH D . 
Q 4 HOH 67  767 45  HOH HOH D . 
Q 4 HOH 68  768 28  HOH HOH D . 
Q 4 HOH 69  769 211 HOH HOH D . 
Q 4 HOH 70  770 272 HOH HOH D . 
Q 4 HOH 71  771 110 HOH HOH D . 
Q 4 HOH 72  772 107 HOH HOH D . 
Q 4 HOH 73  773 47  HOH HOH D . 
Q 4 HOH 74  774 325 HOH HOH D . 
Q 4 HOH 75  775 201 HOH HOH D . 
Q 4 HOH 76  776 324 HOH HOH D . 
Q 4 HOH 77  777 315 HOH HOH D . 
Q 4 HOH 78  778 91  HOH HOH D . 
Q 4 HOH 79  779 138 HOH HOH D . 
Q 4 HOH 80  780 125 HOH HOH D . 
Q 4 HOH 81  781 322 HOH HOH D . 
Q 4 HOH 82  782 333 HOH HOH D . 
Q 4 HOH 83  783 326 HOH HOH D . 
Q 4 HOH 84  784 33  HOH HOH D . 
Q 4 HOH 85  785 215 HOH HOH D . 
Q 4 HOH 86  786 105 HOH HOH D . 
Q 4 HOH 87  787 206 HOH HOH D . 
Q 4 HOH 88  788 42  HOH HOH D . 
Q 4 HOH 89  789 323 HOH HOH D . 
Q 4 HOH 90  790 277 HOH HOH D . 
Q 4 HOH 91  791 342 HOH HOH D . 
Q 4 HOH 92  792 334 HOH HOH D . 
Q 4 HOH 93  793 274 HOH HOH D . 
Q 4 HOH 94  794 133 HOH HOH D . 
Q 4 HOH 95  795 254 HOH HOH D . 
Q 4 HOH 96  796 58  HOH HOH D . 
Q 4 HOH 97  797 290 HOH HOH D . 
Q 4 HOH 98  798 176 HOH HOH D . 
Q 4 HOH 99  799 298 HOH HOH D . 
Q 4 HOH 100 800 198 HOH HOH D . 
Q 4 HOH 101 801 95  HOH HOH D . 
Q 4 HOH 102 802 109 HOH HOH D . 
Q 4 HOH 103 803 305 HOH HOH D . 
Q 4 HOH 104 804 212 HOH HOH D . 
Q 4 HOH 105 805 205 HOH HOH D . 
Q 4 HOH 106 806 236 HOH HOH D . 
Q 4 HOH 107 807 275 HOH HOH D . 
Q 4 HOH 108 808 216 HOH HOH D . 
Q 4 HOH 109 809 146 HOH HOH D . 
Q 4 HOH 110 810 264 HOH HOH D . 
Q 4 HOH 111 811 227 HOH HOH D . 
Q 4 HOH 112 812 164 HOH HOH D . 
Q 4 HOH 113 813 300 HOH HOH D . 
Q 4 HOH 114 814 299 HOH HOH D . 
Q 4 HOH 115 815 222 HOH HOH D . 
Q 4 HOH 116 816 210 HOH HOH D . 
Q 4 HOH 117 817 225 HOH HOH D . 
Q 4 HOH 118 818 253 HOH HOH D . 
Q 4 HOH 119 819 181 HOH HOH D . 
Q 4 HOH 120 820 255 HOH HOH D . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B LEU 335 ? CG  ? B LEU 3   CG  
2  1 Y 1 B LEU 335 ? CD1 ? B LEU 3   CD1 
3  1 Y 1 B LEU 335 ? CD2 ? B LEU 3   CD2 
4  1 Y 1 B SER 366 ? OG  ? B SER 34  OG  
5  1 Y 1 B VAL 367 ? CG1 ? B VAL 35  CG1 
6  1 Y 1 B VAL 367 ? CG2 ? B VAL 35  CG2 
7  1 Y 1 B LEU 368 ? CG  ? B LEU 36  CG  
8  1 Y 1 B LEU 368 ? CD1 ? B LEU 36  CD1 
9  1 Y 1 B LEU 368 ? CD2 ? B LEU 36  CD2 
10 1 Y 1 B TYR 369 ? CG  ? B TYR 37  CG  
11 1 Y 1 B TYR 369 ? CD1 ? B TYR 37  CD1 
12 1 Y 1 B TYR 369 ? CD2 ? B TYR 37  CD2 
13 1 Y 1 B TYR 369 ? CE1 ? B TYR 37  CE1 
14 1 Y 1 B TYR 369 ? CE2 ? B TYR 37  CE2 
15 1 Y 1 B TYR 369 ? CZ  ? B TYR 37  CZ  
16 1 Y 1 B TYR 369 ? OH  ? B TYR 37  OH  
17 1 Y 1 B ASN 370 ? CG  ? B ASN 38  CG  
18 1 Y 1 B ASN 370 ? OD1 ? B ASN 38  OD1 
19 1 Y 1 B ASN 370 ? ND2 ? B ASN 38  ND2 
20 1 Y 1 B PHE 371 ? CG  ? B PHE 39  CG  
21 1 Y 1 B PHE 371 ? CD1 ? B PHE 39  CD1 
22 1 Y 1 B PHE 371 ? CD2 ? B PHE 39  CD2 
23 1 Y 1 B PHE 371 ? CE1 ? B PHE 39  CE1 
24 1 Y 1 B PHE 371 ? CE2 ? B PHE 39  CE2 
25 1 Y 1 B PHE 371 ? CZ  ? B PHE 39  CZ  
26 1 Y 1 B PHE 374 ? CG  ? B PHE 42  CG  
27 1 Y 1 B PHE 374 ? CD1 ? B PHE 42  CD1 
28 1 Y 1 B PHE 374 ? CD2 ? B PHE 42  CD2 
29 1 Y 1 B PHE 374 ? CE1 ? B PHE 42  CE1 
30 1 Y 1 B PHE 374 ? CE2 ? B PHE 42  CE2 
31 1 Y 1 B PHE 374 ? CZ  ? B PHE 42  CZ  
32 1 Y 1 B HIS 519 ? CG  ? B HIS 187 CG  
33 1 Y 1 B HIS 519 ? ND1 ? B HIS 187 ND1 
34 1 Y 1 B HIS 519 ? CD2 ? B HIS 187 CD2 
35 1 Y 1 B HIS 519 ? CE1 ? B HIS 187 CE1 
36 1 Y 1 B HIS 519 ? NE2 ? B HIS 187 NE2 
37 1 Y 1 B SER 527 ? OG  ? B SER 195 OG  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YDV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     87.480 
_cell.length_a_esd                 ? 
_cell.length_b                     87.480 
_cell.length_b_esd                 ? 
_cell.length_c                     118.230 
_cell.length_c_esd                 ? 
_cell.volume                       904784.680 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YDV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                76 
_symmetry.space_group_name_Hall            'P 4w' 
_symmetry.space_group_name_H-M             'P 41' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YDV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.65 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          66.29 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES (pH 7.5), 10% PEG 6000, 5% MPD' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          43.59 
_reflns.entry_id                                       8YDV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     45117 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.99 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.20 
_reflns_shell.d_res_low                                     2.33 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             7081 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.564 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               51.82 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YDV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             48.98 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     45072 
_refine.ls_number_reflns_R_free                  2254 
_refine.ls_number_reflns_R_work                  42818 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.97 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1966 
_refine.ls_R_factor_R_free                       0.2210 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1953 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.3544 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3454 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        48.98 
_refine_hist.number_atoms_solvent             297 
_refine_hist.number_atoms_total               4088 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3737 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         54 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0031  ? 3876 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5104  ? 5241 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0438  ? 546  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0044  ? 680  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 10.5258 ? 1394 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.25  . . 143 2669 100.00 . . . . 0.3283 . . . . . . . . . . . 0.3327 
'X-RAY DIFFRACTION' 2.25 2.30  . . 142 2663 99.93  . . . . 0.3090 . . . . . . . . . . . 0.4019 
'X-RAY DIFFRACTION' 2.30 2.36  . . 141 2659 100.00 . . . . 0.2823 . . . . . . . . . . . 0.3378 
'X-RAY DIFFRACTION' 2.36 2.42  . . 139 2655 99.96  . . . . 0.2704 . . . . . . . . . . . 0.3007 
'X-RAY DIFFRACTION' 2.42 2.49  . . 140 2667 100.00 . . . . 0.2624 . . . . . . . . . . . 0.3340 
'X-RAY DIFFRACTION' 2.49 2.57  . . 140 2692 100.00 . . . . 0.2524 . . . . . . . . . . . 0.3361 
'X-RAY DIFFRACTION' 2.57 2.67  . . 142 2644 100.00 . . . . 0.2318 . . . . . . . . . . . 0.2819 
'X-RAY DIFFRACTION' 2.67 2.77  . . 141 2659 100.00 . . . . 0.2474 . . . . . . . . . . . 0.3053 
'X-RAY DIFFRACTION' 2.77 2.90  . . 140 2688 100.00 . . . . 0.2239 . . . . . . . . . . . 0.2792 
'X-RAY DIFFRACTION' 2.90 3.05  . . 143 2663 100.00 . . . . 0.2044 . . . . . . . . . . . 0.2547 
'X-RAY DIFFRACTION' 3.05 3.24  . . 142 2683 100.00 . . . . 0.1966 . . . . . . . . . . . 0.2158 
'X-RAY DIFFRACTION' 3.24 3.49  . . 138 2696 100.00 . . . . 0.1888 . . . . . . . . . . . 0.1801 
'X-RAY DIFFRACTION' 3.49 3.84  . . 136 2670 100.00 . . . . 0.1728 . . . . . . . . . . . 0.1810 
'X-RAY DIFFRACTION' 3.84 4.40  . . 140 2695 100.00 . . . . 0.1555 . . . . . . . . . . . 0.1734 
'X-RAY DIFFRACTION' 4.40 5.54  . . 140 2692 100.00 . . . . 0.1529 . . . . . . . . . . . 0.1750 
'X-RAY DIFFRACTION' 5.54 48.98 . . 147 2723 99.69  . . . . 0.1775 . . . . . . . . . . . 0.1928 
# 
_struct.entry_id                     8YDV 
_struct.title                        
'Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.5 variant spike protein in complex with CeSPIACE' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YDV 
_struct_keywords.text            'RBD, VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 3 ? 
M N N 3 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8YDV        8YDV   ? 1 ? 1   
2 UNP SPIKE_SARS2 P0DTC2 ? 2 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
;
333 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YDV A 1 ? 39  ? 8YDV   1   ? 39  ? 1   39  
2 2 8YDV B 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
3 1 8YDV C 1 ? 39  ? 8YDV   1   ? 39  ? 1   39  
4 2 8YDV D 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8YDV ASP B 7   ? UNP P0DTC2 GLY 339 variant          339 1   
2 8YDV PHE B 39  ? UNP P0DTC2 SER 371 variant          371 2   
2 8YDV PRO B 41  ? UNP P0DTC2 SER 373 variant          373 3   
2 8YDV ALA B 44  ? UNP P0DTC2 THR 376 variant          376 4   
2 8YDV ASN B 73  ? UNP P0DTC2 ASP 405 variant          405 5   
2 8YDV SER B 76  ? UNP P0DTC2 ARG 408 variant          408 6   
2 8YDV ASN B 85  ? UNP P0DTC2 LYS 417 variant          417 7   
2 8YDV LYS B 108 ? UNP P0DTC2 ASN 440 variant          440 8   
2 8YDV ARG B 120 ? UNP P0DTC2 LEU 452 variant          452 9   
2 8YDV ASN B 145 ? UNP P0DTC2 SER 477 variant          477 10  
2 8YDV LYS B 146 ? UNP P0DTC2 THR 478 variant          478 11  
2 8YDV ALA B 152 ? UNP P0DTC2 GLU 484 variant          484 12  
2 8YDV VAL B 154 ? UNP P0DTC2 PHE 486 variant          486 13  
2 8YDV ARG B 166 ? UNP P0DTC2 GLN 498 variant          498 14  
2 8YDV TYR B 169 ? UNP P0DTC2 ASN 501 variant          501 15  
2 8YDV HIS B 173 ? UNP P0DTC2 TYR 505 variant          505 16  
2 8YDV SER B 195 ? UNP P0DTC2 ?   ?   'expression tag' 527 17  
2 8YDV ASN B 196 ? UNP P0DTC2 ?   ?   'expression tag' 528 18  
2 8YDV SER B 197 ? UNP P0DTC2 ?   ?   'expression tag' 529 19  
2 8YDV GLU B 198 ? UNP P0DTC2 ?   ?   'expression tag' 530 20  
2 8YDV ASN B 199 ? UNP P0DTC2 ?   ?   'expression tag' 531 21  
2 8YDV LEU B 200 ? UNP P0DTC2 ?   ?   'expression tag' 532 22  
2 8YDV TYR B 201 ? UNP P0DTC2 ?   ?   'expression tag' 533 23  
2 8YDV PHE B 202 ? UNP P0DTC2 ?   ?   'expression tag' 534 24  
2 8YDV GLN B 203 ? UNP P0DTC2 ?   ?   'expression tag' 535 25  
2 8YDV GLY B 204 ? UNP P0DTC2 ?   ?   'expression tag' 536 26  
2 8YDV SER B 205 ? UNP P0DTC2 ?   ?   'expression tag' 537 27  
2 8YDV HIS B 206 ? UNP P0DTC2 ?   ?   'expression tag' 538 28  
2 8YDV HIS B 207 ? UNP P0DTC2 ?   ?   'expression tag' 539 29  
2 8YDV HIS B 208 ? UNP P0DTC2 ?   ?   'expression tag' 540 30  
2 8YDV HIS B 209 ? UNP P0DTC2 ?   ?   'expression tag' 541 31  
2 8YDV HIS B 210 ? UNP P0DTC2 ?   ?   'expression tag' 542 32  
2 8YDV HIS B 211 ? UNP P0DTC2 ?   ?   'expression tag' 543 33  
2 8YDV HIS B 212 ? UNP P0DTC2 ?   ?   'expression tag' 544 34  
2 8YDV HIS B 213 ? UNP P0DTC2 ?   ?   'expression tag' 545 35  
2 8YDV HIS B 214 ? UNP P0DTC2 ?   ?   'expression tag' 546 36  
2 8YDV HIS B 215 ? UNP P0DTC2 ?   ?   'expression tag' 547 37  
2 8YDV GLY B 216 ? UNP P0DTC2 ?   ?   'expression tag' 548 38  
2 8YDV LEU B 217 ? UNP P0DTC2 ?   ?   'expression tag' 549 39  
2 8YDV ASN B 218 ? UNP P0DTC2 ?   ?   'expression tag' 550 40  
2 8YDV ASP B 219 ? UNP P0DTC2 ?   ?   'expression tag' 551 41  
2 8YDV ILE B 220 ? UNP P0DTC2 ?   ?   'expression tag' 552 42  
2 8YDV PHE B 221 ? UNP P0DTC2 ?   ?   'expression tag' 553 43  
2 8YDV GLU B 222 ? UNP P0DTC2 ?   ?   'expression tag' 554 44  
2 8YDV ALA B 223 ? UNP P0DTC2 ?   ?   'expression tag' 555 45  
2 8YDV GLN B 224 ? UNP P0DTC2 ?   ?   'expression tag' 556 46  
2 8YDV LYS B 225 ? UNP P0DTC2 ?   ?   'expression tag' 557 47  
2 8YDV ILE B 226 ? UNP P0DTC2 ?   ?   'expression tag' 558 48  
2 8YDV GLU B 227 ? UNP P0DTC2 ?   ?   'expression tag' 559 49  
2 8YDV TRP B 228 ? UNP P0DTC2 ?   ?   'expression tag' 560 50  
2 8YDV HIS B 229 ? UNP P0DTC2 ?   ?   'expression tag' 561 51  
2 8YDV GLU B 230 ? UNP P0DTC2 ?   ?   'expression tag' 562 52  
4 8YDV ASP D 7   ? UNP P0DTC2 GLY 339 variant          339 53  
4 8YDV PHE D 39  ? UNP P0DTC2 SER 371 variant          371 54  
4 8YDV PRO D 41  ? UNP P0DTC2 SER 373 variant          373 55  
4 8YDV ALA D 44  ? UNP P0DTC2 THR 376 variant          376 56  
4 8YDV ASN D 73  ? UNP P0DTC2 ASP 405 variant          405 57  
4 8YDV SER D 76  ? UNP P0DTC2 ARG 408 variant          408 58  
4 8YDV ASN D 85  ? UNP P0DTC2 LYS 417 variant          417 59  
4 8YDV LYS D 108 ? UNP P0DTC2 ASN 440 variant          440 60  
4 8YDV ARG D 120 ? UNP P0DTC2 LEU 452 variant          452 61  
4 8YDV ASN D 145 ? UNP P0DTC2 SER 477 variant          477 62  
4 8YDV LYS D 146 ? UNP P0DTC2 THR 478 variant          478 63  
4 8YDV ALA D 152 ? UNP P0DTC2 GLU 484 variant          484 64  
4 8YDV VAL D 154 ? UNP P0DTC2 PHE 486 variant          486 65  
4 8YDV ARG D 166 ? UNP P0DTC2 GLN 498 variant          498 66  
4 8YDV TYR D 169 ? UNP P0DTC2 ASN 501 variant          501 67  
4 8YDV HIS D 173 ? UNP P0DTC2 TYR 505 variant          505 68  
4 8YDV SER D 195 ? UNP P0DTC2 ?   ?   'expression tag' 527 69  
4 8YDV ASN D 196 ? UNP P0DTC2 ?   ?   'expression tag' 528 70  
4 8YDV SER D 197 ? UNP P0DTC2 ?   ?   'expression tag' 529 71  
4 8YDV GLU D 198 ? UNP P0DTC2 ?   ?   'expression tag' 530 72  
4 8YDV ASN D 199 ? UNP P0DTC2 ?   ?   'expression tag' 531 73  
4 8YDV LEU D 200 ? UNP P0DTC2 ?   ?   'expression tag' 532 74  
4 8YDV TYR D 201 ? UNP P0DTC2 ?   ?   'expression tag' 533 75  
4 8YDV PHE D 202 ? UNP P0DTC2 ?   ?   'expression tag' 534 76  
4 8YDV GLN D 203 ? UNP P0DTC2 ?   ?   'expression tag' 535 77  
4 8YDV GLY D 204 ? UNP P0DTC2 ?   ?   'expression tag' 536 78  
4 8YDV SER D 205 ? UNP P0DTC2 ?   ?   'expression tag' 537 79  
4 8YDV HIS D 206 ? UNP P0DTC2 ?   ?   'expression tag' 538 80  
4 8YDV HIS D 207 ? UNP P0DTC2 ?   ?   'expression tag' 539 81  
4 8YDV HIS D 208 ? UNP P0DTC2 ?   ?   'expression tag' 540 82  
4 8YDV HIS D 209 ? UNP P0DTC2 ?   ?   'expression tag' 541 83  
4 8YDV HIS D 210 ? UNP P0DTC2 ?   ?   'expression tag' 542 84  
4 8YDV HIS D 211 ? UNP P0DTC2 ?   ?   'expression tag' 543 85  
4 8YDV HIS D 212 ? UNP P0DTC2 ?   ?   'expression tag' 544 86  
4 8YDV HIS D 213 ? UNP P0DTC2 ?   ?   'expression tag' 545 87  
4 8YDV HIS D 214 ? UNP P0DTC2 ?   ?   'expression tag' 546 88  
4 8YDV HIS D 215 ? UNP P0DTC2 ?   ?   'expression tag' 547 89  
4 8YDV GLY D 216 ? UNP P0DTC2 ?   ?   'expression tag' 548 90  
4 8YDV LEU D 217 ? UNP P0DTC2 ?   ?   'expression tag' 549 91  
4 8YDV ASN D 218 ? UNP P0DTC2 ?   ?   'expression tag' 550 92  
4 8YDV ASP D 219 ? UNP P0DTC2 ?   ?   'expression tag' 551 93  
4 8YDV ILE D 220 ? UNP P0DTC2 ?   ?   'expression tag' 552 94  
4 8YDV PHE D 221 ? UNP P0DTC2 ?   ?   'expression tag' 553 95  
4 8YDV GLU D 222 ? UNP P0DTC2 ?   ?   'expression tag' 554 96  
4 8YDV ALA D 223 ? UNP P0DTC2 ?   ?   'expression tag' 555 97  
4 8YDV GLN D 224 ? UNP P0DTC2 ?   ?   'expression tag' 556 98  
4 8YDV LYS D 225 ? UNP P0DTC2 ?   ?   'expression tag' 557 99  
4 8YDV ILE D 226 ? UNP P0DTC2 ?   ?   'expression tag' 558 100 
4 8YDV GLU D 227 ? UNP P0DTC2 ?   ?   'expression tag' 559 101 
4 8YDV TRP D 228 ? UNP P0DTC2 ?   ?   'expression tag' 560 102 
4 8YDV HIS D 229 ? UNP P0DTC2 ?   ?   'expression tag' 561 103 
4 8YDV GLU D 230 ? UNP P0DTC2 ?   ?   'expression tag' 562 104 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2300  ? 
1 MORE         -7    ? 
1 'SSA (A^2)'  11930 ? 
2 'ABSA (A^2)' 3490  ? 
2 MORE         -7    ? 
2 'SSA (A^2)'  12000 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,N,O           
2 1 C,D,G,H,I,J,K,L,M,P,Q 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 1   ? GLU A 19  ? ASP A 1   GLU A 19  1 ? 19 
HELX_P HELX_P2  AA2 HIS A 21  ? LYS A 37  ? HIS A 21  LYS A 37  1 ? 17 
HELX_P HELX_P3  AA3 PHE B 6   ? ASN B 11  ? PHE B 338 ASN B 343 1 ? 6  
HELX_P HELX_P4  AA4 SER B 17  ? TRP B 21  ? SER B 349 TRP B 353 5 ? 5  
HELX_P HELX_P5  AA5 ASP B 32  ? PHE B 39  ? ASP B 364 PHE B 371 5 ? 8  
HELX_P HELX_P6  AA6 SER B 51  ? ASN B 56  ? SER B 383 ASN B 388 1 ? 6  
HELX_P HELX_P7  AA7 ASN B 73  ? ILE B 78  ? ASN B 405 ILE B 410 5 ? 6  
HELX_P HELX_P8  AA8 GLY B 84  ? ASN B 90  ? GLY B 416 ASN B 422 1 ? 7  
HELX_P HELX_P9  AA9 SER B 106 ? SER B 111 ? SER B 438 SER B 443 1 ? 6  
HELX_P HELX_P10 AB1 GLY B 170 ? HIS B 173 ? GLY B 502 HIS B 505 5 ? 4  
HELX_P HELX_P11 AB2 LYS C 2   ? GLU C 19  ? LYS C 2   GLU C 19  1 ? 18 
HELX_P HELX_P12 AB3 HIS C 21  ? ARG C 38  ? HIS C 21  ARG C 38  1 ? 18 
HELX_P HELX_P13 AB4 PRO D 5   ? ASN D 11  ? PRO D 337 ASN D 343 1 ? 7  
HELX_P HELX_P14 AB5 ASP D 32  ? PHE D 39  ? ASP D 364 PHE D 371 5 ? 8  
HELX_P HELX_P15 AB6 SER D 51  ? ASN D 56  ? SER D 383 ASN D 388 1 ? 6  
HELX_P HELX_P16 AB7 ASN D 73  ? ILE D 78  ? ASN D 405 ILE D 410 5 ? 6  
HELX_P HELX_P17 AB8 GLY D 84  ? ASN D 90  ? GLY D 416 ASN D 422 1 ? 7  
HELX_P HELX_P18 AB9 SER D 106 ? SER D 111 ? SER D 438 SER D 443 1 ? 6  
HELX_P HELX_P19 AC1 GLY D 170 ? HIS D 173 ? GLY D 502 HIS D 505 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? B CYS 4   SG ? ? ? 1_555 B CYS 29  SG ? ? B CYS 336 B CYS 361 1_555 ? ? ? ? ? ? ? 2.036 ? ? 
disulf2 disulf ? ? B CYS 47  SG ? ? ? 1_555 B CYS 100 SG ? ? B CYS 379 B CYS 432 1_555 ? ? ? ? ? ? ? 2.041 ? ? 
disulf3 disulf ? ? B CYS 59  SG ? ? ? 1_555 B CYS 193 SG ? ? B CYS 391 B CYS 525 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf4 disulf ? ? B CYS 148 SG ? ? ? 1_555 B CYS 156 SG ? ? B CYS 480 B CYS 488 1_555 ? ? ? ? ? ? ? 2.047 ? ? 
disulf5 disulf ? ? D CYS 4   SG ? ? ? 1_555 D CYS 29  SG ? ? D CYS 336 D CYS 361 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
disulf6 disulf ? ? D CYS 47  SG ? ? ? 1_555 D CYS 100 SG ? ? D CYS 379 D CYS 432 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf7 disulf ? ? D CYS 59  SG ? ? ? 1_555 D CYS 193 SG ? ? D CYS 391 D CYS 525 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
disulf8 disulf ? ? D CYS 148 SG ? ? ? 1_555 D CYS 156 SG ? ? D CYS 480 D CYS 488 1_555 ? ? ? ? ? ? ? 2.043 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS B 4   ? CYS B 29  ? CYS B 336 ? 1_555 CYS B 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 47  ? CYS B 100 ? CYS B 379 ? 1_555 CYS B 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 59  ? CYS B 193 ? CYS B 391 ? 1_555 CYS B 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 148 ? CYS B 156 ? CYS B 480 ? 1_555 CYS B 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS D 4   ? CYS D 29  ? CYS D 336 ? 1_555 CYS D 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS D 47  ? CYS D 100 ? CYS D 379 ? 1_555 CYS D 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS D 59  ? CYS D 193 ? CYS D 391 ? 1_555 CYS D 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS D 148 ? CYS D 156 ? CYS D 480 ? 1_555 CYS D 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
AA7 ? 2 ? 
AA8 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN B 22  ? ILE B 26  ? ASN B 354 ILE B 358 
AA1 2 ASN B 62  ? ARG B 71  ? ASN B 394 ARG B 403 
AA1 3 PRO B 175 ? GLU B 184 ? PRO B 507 GLU B 516 
AA1 4 CYS B 100 ? ASN B 105 ? CYS B 432 ASN B 437 
AA1 5 PHE B 45  ? CYS B 47  ? PHE B 377 CYS B 379 
AA2 1 CYS B 29  ? VAL B 30  ? CYS B 361 VAL B 362 
AA2 2 VAL B 192 ? CYS B 193 ? VAL B 524 CYS B 525 
AA2 3 CYS B 59  ? PHE B 60  ? CYS B 391 PHE B 392 
AA3 1 ARG B 120 ? ARG B 122 ? ARG B 452 ARG B 454 
AA3 2 LEU B 160 ? SER B 162 ? LEU B 492 SER B 494 
AA4 1 TYR B 141 ? GLN B 142 ? TYR B 473 GLN B 474 
AA4 2 CYS B 156 ? TYR B 157 ? CYS B 488 TYR B 489 
AA5 1 ASN D 22  ? ILE D 26  ? ASN D 354 ILE D 358 
AA5 2 ASN D 62  ? ARG D 71  ? ASN D 394 ARG D 403 
AA5 3 PRO D 175 ? GLU D 184 ? PRO D 507 GLU D 516 
AA5 4 CYS D 100 ? ASN D 105 ? CYS D 432 ASN D 437 
AA5 5 SER D 43  ? CYS D 47  ? SER D 375 CYS D 379 
AA6 1 CYS D 29  ? ALA D 31  ? CYS D 361 ALA D 363 
AA6 2 VAL D 192 ? GLY D 194 ? VAL D 524 GLY D 526 
AA6 3 CYS D 59  ? PHE D 60  ? CYS D 391 PHE D 392 
AA7 1 ARG D 120 ? ARG D 122 ? ARG D 452 ARG D 454 
AA7 2 LEU D 160 ? SER D 162 ? LEU D 492 SER D 494 
AA8 1 TYR D 141 ? GLN D 142 ? TYR D 473 GLN D 474 
AA8 2 CYS D 156 ? TYR D 157 ? CYS D 488 TYR D 489 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE B 26  ? N ILE B 358 O VAL B 63  ? O VAL B 395 
AA1 2 3 N ASP B 66  ? N ASP B 398 O VAL B 180 ? O VAL B 512 
AA1 3 4 O VAL B 179 ? O VAL B 511 N ILE B 102 ? N ILE B 434 
AA1 4 5 O VAL B 101 ? O VAL B 433 N LYS B 46  ? N LYS B 378 
AA2 1 2 N CYS B 29  ? N CYS B 361 O CYS B 193 ? O CYS B 525 
AA2 2 3 O VAL B 192 ? O VAL B 524 N PHE B 60  ? N PHE B 392 
AA3 1 2 N TYR B 121 ? N TYR B 453 O GLN B 161 ? O GLN B 493 
AA4 1 2 N TYR B 141 ? N TYR B 473 O TYR B 157 ? O TYR B 489 
AA5 1 2 N ILE D 26  ? N ILE D 358 O VAL D 63  ? O VAL D 395 
AA5 2 3 N ASP D 66  ? N ASP D 398 O VAL D 180 ? O VAL D 512 
AA5 3 4 O VAL D 179 ? O VAL D 511 N ILE D 102 ? N ILE D 434 
AA5 4 5 O ALA D 103 ? O ALA D 435 N ALA D 44  ? N ALA D 376 
AA6 1 2 N ALA D 31  ? N ALA D 363 O CYS D 193 ? O CYS D 525 
AA6 2 3 O VAL D 192 ? O VAL D 524 N PHE D 60  ? N PHE D 392 
AA7 1 2 N TYR D 121 ? N TYR D 453 O GLN D 161 ? O GLN D 493 
AA8 1 2 N TYR D 141 ? N TYR D 473 O TYR D 157 ? O TYR D 489 
# 
_pdbx_entry_details.entry_id                   8YDV 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN B 422 ? ? -125.93 -62.16 
2 1 ASN B 528 ? ? -93.30  33.94  
3 1 HIS C 21  ? ? -118.87 63.84  
4 1 ASN D 422 ? ? -131.44 -60.75 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -y,x,z+1/4  
3 y,-x,z+3/4  
4 -x,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B THR 333 ? B THR 1   
2  1 Y 1 B ALA 372 ? B ALA 40  
3  1 Y 1 B PRO 373 ? B PRO 41  
4  1 Y 1 B GLU 530 ? B GLU 198 
5  1 Y 1 B ASN 531 ? B ASN 199 
6  1 Y 1 B LEU 532 ? B LEU 200 
7  1 Y 1 B TYR 533 ? B TYR 201 
8  1 Y 1 B PHE 534 ? B PHE 202 
9  1 Y 1 B GLN 535 ? B GLN 203 
10 1 Y 1 B GLY 536 ? B GLY 204 
11 1 Y 1 B SER 537 ? B SER 205 
12 1 Y 1 B HIS 538 ? B HIS 206 
13 1 Y 1 B HIS 539 ? B HIS 207 
14 1 Y 1 B HIS 540 ? B HIS 208 
15 1 Y 1 B HIS 541 ? B HIS 209 
16 1 Y 1 B HIS 542 ? B HIS 210 
17 1 Y 1 B HIS 543 ? B HIS 211 
18 1 Y 1 B HIS 544 ? B HIS 212 
19 1 Y 1 B HIS 545 ? B HIS 213 
20 1 Y 1 B HIS 546 ? B HIS 214 
21 1 Y 1 B HIS 547 ? B HIS 215 
22 1 Y 1 B GLY 548 ? B GLY 216 
23 1 Y 1 B LEU 549 ? B LEU 217 
24 1 Y 1 B ASN 550 ? B ASN 218 
25 1 Y 1 B ASP 551 ? B ASP 219 
26 1 Y 1 B ILE 552 ? B ILE 220 
27 1 Y 1 B PHE 553 ? B PHE 221 
28 1 Y 1 B GLU 554 ? B GLU 222 
29 1 Y 1 B ALA 555 ? B ALA 223 
30 1 Y 1 B GLN 556 ? B GLN 224 
31 1 Y 1 B LYS 557 ? B LYS 225 
32 1 Y 1 B ILE 558 ? B ILE 226 
33 1 Y 1 B GLU 559 ? B GLU 227 
34 1 Y 1 B TRP 560 ? B TRP 228 
35 1 Y 1 B HIS 561 ? B HIS 229 
36 1 Y 1 B GLU 562 ? B GLU 230 
37 1 Y 1 D ASN 531 ? D ASN 199 
38 1 Y 1 D LEU 532 ? D LEU 200 
39 1 Y 1 D TYR 533 ? D TYR 201 
40 1 Y 1 D PHE 534 ? D PHE 202 
41 1 Y 1 D GLN 535 ? D GLN 203 
42 1 Y 1 D GLY 536 ? D GLY 204 
43 1 Y 1 D SER 537 ? D SER 205 
44 1 Y 1 D HIS 538 ? D HIS 206 
45 1 Y 1 D HIS 539 ? D HIS 207 
46 1 Y 1 D HIS 540 ? D HIS 208 
47 1 Y 1 D HIS 541 ? D HIS 209 
48 1 Y 1 D HIS 542 ? D HIS 210 
49 1 Y 1 D HIS 543 ? D HIS 211 
50 1 Y 1 D HIS 544 ? D HIS 212 
51 1 Y 1 D HIS 545 ? D HIS 213 
52 1 Y 1 D HIS 546 ? D HIS 214 
53 1 Y 1 D HIS 547 ? D HIS 215 
54 1 Y 1 D GLY 548 ? D GLY 216 
55 1 Y 1 D LEU 549 ? D LEU 217 
56 1 Y 1 D ASN 550 ? D ASN 218 
57 1 Y 1 D ASP 551 ? D ASP 219 
58 1 Y 1 D ILE 552 ? D ILE 220 
59 1 Y 1 D PHE 553 ? D PHE 221 
60 1 Y 1 D GLU 554 ? D GLU 222 
61 1 Y 1 D ALA 555 ? D ALA 223 
62 1 Y 1 D GLN 556 ? D GLN 224 
63 1 Y 1 D LYS 557 ? D LYS 225 
64 1 Y 1 D ILE 558 ? D ILE 226 
65 1 Y 1 D GLU 559 ? D GLU 227 
66 1 Y 1 D TRP 560 ? D TRP 228 
67 1 Y 1 D HIS 561 ? D HIS 229 
68 1 Y 1 D GLU 562 ? D GLU 230 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
PHE N    N N N 264 
PHE CA   C N S 265 
PHE C    C N N 266 
PHE O    O N N 267 
PHE CB   C N N 268 
PHE CG   C Y N 269 
PHE CD1  C Y N 270 
PHE CD2  C Y N 271 
PHE CE1  C Y N 272 
PHE CE2  C Y N 273 
PHE CZ   C Y N 274 
PHE OXT  O N N 275 
PHE H    H N N 276 
PHE H2   H N N 277 
PHE HA   H N N 278 
PHE HB2  H N N 279 
PHE HB3  H N N 280 
PHE HD1  H N N 281 
PHE HD2  H N N 282 
PHE HE1  H N N 283 
PHE HE2  H N N 284 
PHE HZ   H N N 285 
PHE HXT  H N N 286 
PRO N    N N N 287 
PRO CA   C N S 288 
PRO C    C N N 289 
PRO O    O N N 290 
PRO CB   C N N 291 
PRO CG   C N N 292 
PRO CD   C N N 293 
PRO OXT  O N N 294 
PRO H    H N N 295 
PRO HA   H N N 296 
PRO HB2  H N N 297 
PRO HB3  H N N 298 
PRO HG2  H N N 299 
PRO HG3  H N N 300 
PRO HD2  H N N 301 
PRO HD3  H N N 302 
PRO HXT  H N N 303 
SER N    N N N 304 
SER CA   C N S 305 
SER C    C N N 306 
SER O    O N N 307 
SER CB   C N N 308 
SER OG   O N N 309 
SER OXT  O N N 310 
SER H    H N N 311 
SER H2   H N N 312 
SER HA   H N N 313 
SER HB2  H N N 314 
SER HB3  H N N 315 
SER HG   H N N 316 
SER HXT  H N N 317 
THR N    N N N 318 
THR CA   C N S 319 
THR C    C N N 320 
THR O    O N N 321 
THR CB   C N R 322 
THR OG1  O N N 323 
THR CG2  C N N 324 
THR OXT  O N N 325 
THR H    H N N 326 
THR H2   H N N 327 
THR HA   H N N 328 
THR HB   H N N 329 
THR HG1  H N N 330 
THR HG21 H N N 331 
THR HG22 H N N 332 
THR HG23 H N N 333 
THR HXT  H N N 334 
TRP N    N N N 335 
TRP CA   C N S 336 
TRP C    C N N 337 
TRP O    O N N 338 
TRP CB   C N N 339 
TRP CG   C Y N 340 
TRP CD1  C Y N 341 
TRP CD2  C Y N 342 
TRP NE1  N Y N 343 
TRP CE2  C Y N 344 
TRP CE3  C Y N 345 
TRP CZ2  C Y N 346 
TRP CZ3  C Y N 347 
TRP CH2  C Y N 348 
TRP OXT  O N N 349 
TRP H    H N N 350 
TRP H2   H N N 351 
TRP HA   H N N 352 
TRP HB2  H N N 353 
TRP HB3  H N N 354 
TRP HD1  H N N 355 
TRP HE1  H N N 356 
TRP HE3  H N N 357 
TRP HZ2  H N N 358 
TRP HZ3  H N N 359 
TRP HH2  H N N 360 
TRP HXT  H N N 361 
TYR N    N N N 362 
TYR CA   C N S 363 
TYR C    C N N 364 
TYR O    O N N 365 
TYR CB   C N N 366 
TYR CG   C Y N 367 
TYR CD1  C Y N 368 
TYR CD2  C Y N 369 
TYR CE1  C Y N 370 
TYR CE2  C Y N 371 
TYR CZ   C Y N 372 
TYR OH   O N N 373 
TYR OXT  O N N 374 
TYR H    H N N 375 
TYR H2   H N N 376 
TYR HA   H N N 377 
TYR HB2  H N N 378 
TYR HB3  H N N 379 
TYR HD1  H N N 380 
TYR HD2  H N N 381 
TYR HE1  H N N 382 
TYR HE2  H N N 383 
TYR HH   H N N 384 
TYR HXT  H N N 385 
VAL N    N N N 386 
VAL CA   C N S 387 
VAL C    C N N 388 
VAL O    O N N 389 
VAL CB   C N N 390 
VAL CG1  C N N 391 
VAL CG2  C N N 392 
VAL OXT  O N N 393 
VAL H    H N N 394 
VAL H2   H N N 395 
VAL HA   H N N 396 
VAL HB   H N N 397 
VAL HG11 H N N 398 
VAL HG12 H N N 399 
VAL HG13 H N N 400 
VAL HG21 H N N 401 
VAL HG22 H N N 402 
VAL HG23 H N N 403 
VAL HXT  H N N 404 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan 'JP21fk0108462, JP21fk0108585, JP21ae0121028, JP18ae0101046' 1 
'Japan Society for the Promotion of Science (JSPS)'        Japan 20H00451                                                     2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7jzu 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41' 
_space_group.name_Hall        'P 4w' 
_space_group.IT_number        76 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YDV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011431 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011431 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008458 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 1   ? -0.07730  29.28333  8.03423   1.000 81.70473  ? 1   ASP A N   1 
ATOM   2    C CA  . ASP A 1 1   ? -0.46625  27.95115  8.47620   1.000 87.20044  ? 1   ASP A CA  1 
ATOM   3    C C   . ASP A 1 1   ? 0.64817   26.93943  8.22078   1.000 79.53780  ? 1   ASP A C   1 
ATOM   4    O O   . ASP A 1 1   ? 1.40339   27.05929  7.25307   1.000 79.69922  ? 1   ASP A O   1 
ATOM   5    C CB  . ASP A 1 1   ? -1.74796  27.50123  7.76779   1.000 82.92948  ? 1   ASP A CB  1 
ATOM   6    C CG  . ASP A 1 1   ? -1.54981  27.30168  6.27088   1.000 79.66720  ? 1   ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 1   ? -0.73159  28.03355  5.67086   1.000 81.79735  ? 1   ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 1   ? -2.20471  26.40935  5.69340   1.000 77.34449  ? 1   ASP A OD2 1 
ATOM   9    N N   . LYS A 1 2   ? 0.74407   25.93966  9.09453   1.000 69.53716  ? 2   LYS A N   1 
ATOM   10   C CA  . LYS A 1 2   ? 1.65829   24.83124  8.86645   1.000 62.88589  ? 2   LYS A CA  1 
ATOM   11   C C   . LYS A 1 2   ? 1.18370   23.89949  7.75934   1.000 57.36818  ? 2   LYS A C   1 
ATOM   12   O O   . LYS A 1 2   ? 1.97375   23.07396  7.28859   1.000 49.62177  ? 2   LYS A O   1 
ATOM   13   C CB  . LYS A 1 2   ? 1.84727   24.03323  10.16274  1.000 69.02442  ? 2   LYS A CB  1 
ATOM   14   C CG  . LYS A 1 2   ? 2.55601   24.79388  11.27998  1.000 78.33387  ? 2   LYS A CG  1 
ATOM   15   C CD  . LYS A 1 2   ? 2.17506   24.26322  12.66675  1.000 84.71879  ? 2   LYS A CD  1 
ATOM   16   C CE  . LYS A 1 2   ? 2.41574   22.75926  12.81011  1.000 82.52012  ? 2   LYS A CE  1 
ATOM   17   N NZ  . LYS A 1 2   ? 3.86085   22.39289  12.91123  1.000 74.95835  ? 2   LYS A NZ  1 
ATOM   18   N N   . LEU A 1 3   ? -0.07561  24.02178  7.32677   1.000 55.13719  ? 3   LEU A N   1 
ATOM   19   C CA  . LEU A 1 3   ? -0.66501  23.01166  6.45306   1.000 54.55252  ? 3   LEU A CA  1 
ATOM   20   C C   . LEU A 1 3   ? -0.09185  23.07589  5.04327   1.000 48.80898  ? 3   LEU A C   1 
ATOM   21   O O   . LEU A 1 3   ? 0.09154   22.03646  4.39992   1.000 43.88262  ? 3   LEU A O   1 
ATOM   22   C CB  . LEU A 1 3   ? -2.18553  23.16530  6.42272   1.000 53.90569  ? 3   LEU A CB  1 
ATOM   23   C CG  . LEU A 1 3   ? -2.89399  22.85890  7.74295   1.000 51.93762  ? 3   LEU A CG  1 
ATOM   24   C CD1 . LEU A 1 3   ? -4.39766  23.04755  7.60732   1.000 46.53908  ? 3   LEU A CD1 1 
ATOM   25   C CD2 . LEU A 1 3   ? -2.56682  21.44890  8.20598   1.000 43.44223  ? 3   LEU A CD2 1 
ATOM   26   N N   . TRP A 1 4   ? 0.19674   24.27891  4.54263   1.000 49.96779  ? 4   TRP A N   1 
ATOM   27   C CA  . TRP A 1 4   ? 0.72154   24.39681  3.18517   1.000 47.54778  ? 4   TRP A CA  1 
ATOM   28   C C   . TRP A 1 4   ? 2.11551   23.78858  3.08184   1.000 43.33868  ? 4   TRP A C   1 
ATOM   29   O O   . TRP A 1 4   ? 2.38068   22.95795  2.20342   1.000 41.10334  ? 4   TRP A O   1 
ATOM   30   C CB  . TRP A 1 4   ? 0.73988   25.86186  2.74740   1.000 46.52693  ? 4   TRP A CB  1 
ATOM   31   C CG  . TRP A 1 4   ? 1.13931   26.03951  1.31146   1.000 55.85069  ? 4   TRP A CG  1 
ATOM   32   C CD1 . TRP A 1 4   ? 0.31276   26.04341  0.22898   1.000 53.51996  ? 4   TRP A CD1 1 
ATOM   33   C CD2 . TRP A 1 4   ? 2.46679   26.23010  0.80334   1.000 49.72773  ? 4   TRP A CD2 1 
ATOM   34   N NE1 . TRP A 1 4   ? 1.03911   26.22963  -0.92386  1.000 55.71808  ? 4   TRP A NE1 1 
ATOM   35   C CE2 . TRP A 1 4   ? 2.36440   26.34821  -0.59788  1.000 54.79992  ? 4   TRP A CE2 1 
ATOM   36   C CE3 . TRP A 1 4   ? 3.73039   26.31572  1.39719   1.000 49.25002  ? 4   TRP A CE3 1 
ATOM   37   C CZ2 . TRP A 1 4   ? 3.47704   26.54727  -1.41480  1.000 51.33823  ? 4   TRP A CZ2 1 
ATOM   38   C CZ3 . TRP A 1 4   ? 4.83425   26.51166  0.58437   1.000 50.29741  ? 4   TRP A CZ3 1 
ATOM   39   C CH2 . TRP A 1 4   ? 4.70047   26.62372  -0.80629  1.000 52.70869  ? 4   TRP A CH2 1 
ATOM   40   N N   . ILE A 1 5   ? 3.02104   24.18577  3.97677   1.000 43.18638  ? 5   ILE A N   1 
ATOM   41   C CA  . ILE A 1 5   ? 4.38375   23.67402  3.89880   1.000 43.00894  ? 5   ILE A CA  1 
ATOM   42   C C   . ILE A 1 5   ? 4.42519   22.18179  4.21612   1.000 42.90177  ? 5   ILE A C   1 
ATOM   43   O O   . ILE A 1 5   ? 5.23800   21.44502  3.64314   1.000 43.18922  ? 5   ILE A O   1 
ATOM   44   C CB  . ILE A 1 5   ? 5.31545   24.49203  4.81268   1.000 47.84194  ? 5   ILE A CB  1 
ATOM   45   C CG1 . ILE A 1 5   ? 6.76953   24.05382  4.61578   1.000 45.65553  ? 5   ILE A CG1 1 
ATOM   46   C CG2 . ILE A 1 5   ? 4.87292   24.40428  6.27107   1.000 39.24758  ? 5   ILE A CG2 1 
ATOM   47   C CD1 . ILE A 1 5   ? 7.28004   24.27162  3.20101   1.000 43.48982  ? 5   ILE A CD1 1 
ATOM   48   N N   . LEU A 1 6   ? 3.53877   21.69883  5.09301   1.000 38.65990  ? 6   LEU A N   1 
ATOM   49   C CA  . LEU A 1 6   ? 3.45633   20.25932  5.32602   1.000 40.41403  ? 6   LEU A CA  1 
ATOM   50   C C   . LEU A 1 6   ? 3.05686   19.52591  4.05179   1.000 38.58071  ? 6   LEU A C   1 
ATOM   51   O O   . LEU A 1 6   ? 3.66764   18.51217  3.69199   1.000 38.07327  ? 6   LEU A O   1 
ATOM   52   C CB  . LEU A 1 6   ? 2.46782   19.95388  6.45850   1.000 35.50520  ? 6   LEU A CB  1 
ATOM   53   C CG  . LEU A 1 6   ? 2.16444   18.48302  6.79891   1.000 42.58204  ? 6   LEU A CG  1 
ATOM   54   C CD1 . LEU A 1 6   ? 3.41135   17.71448  7.23149   1.000 28.84278  ? 6   LEU A CD1 1 
ATOM   55   C CD2 . LEU A 1 6   ? 1.08205   18.37766  7.87492   1.000 40.63679  ? 6   LEU A CD2 1 
ATOM   56   N N   . GLN A 1 7   ? 2.04032   20.03153  3.34784   1.000 37.43529  ? 7   GLN A N   1 
ATOM   57   C CA  . GLN A 1 7   ? 1.61538   19.39727  2.10331   1.000 36.58767  ? 7   GLN A CA  1 
ATOM   58   C C   . GLN A 1 7   ? 2.74617   19.36832  1.08186   1.000 38.68556  ? 7   GLN A C   1 
ATOM   59   O O   . GLN A 1 7   ? 2.96693   18.34954  0.41492   1.000 35.09753  ? 7   GLN A O   1 
ATOM   60   C CB  . GLN A 1 7   ? 0.39854   20.12279  1.52755   1.000 36.83820  ? 7   GLN A CB  1 
ATOM   61   C CG  . GLN A 1 7   ? -0.13293  19.50102  0.23890   1.000 33.16448  ? 7   GLN A CG  1 
ATOM   62   C CD  . GLN A 1 7   ? -0.65148  18.08926  0.44454   1.000 41.30245  ? 7   GLN A CD  1 
ATOM   63   O OE1 . GLN A 1 7   ? -1.00523  17.70705  1.55760   1.000 39.04474  ? 7   GLN A OE1 1 
ATOM   64   N NE2 . GLN A 1 7   ? -0.70401  17.30764  -0.63254  1.000 37.17808  ? 7   GLN A NE2 1 
ATOM   65   N N   . LYS A 1 8   ? 3.47624   20.47676  0.94631   1.000 40.38147  ? 8   LYS A N   1 
ATOM   66   C CA  . LYS A 1 8   ? 4.56839   20.52268  -0.02258  1.000 37.05449  ? 8   LYS A CA  1 
ATOM   67   C C   . LYS A 1 8   ? 5.65965   19.51591  0.32445   1.000 42.61471  ? 8   LYS A C   1 
ATOM   68   O O   . LYS A 1 8   ? 6.13055   18.77883  -0.55269  1.000 38.14842  ? 8   LYS A O   1 
ATOM   69   C CB  . LYS A 1 8   ? 5.14004   21.93804  -0.10242  1.000 39.39280  ? 8   LYS A CB  1 
ATOM   70   C CG  . LYS A 1 8   ? 4.21248   22.93549  -0.79637  1.000 41.66669  ? 8   LYS A CG  1 
ATOM   71   C CD  . LYS A 1 8   ? 3.88580   22.47197  -2.21410  1.000 44.40430  ? 8   LYS A CD  1 
ATOM   72   C CE  . LYS A 1 8   ? 2.93991   23.42208  -2.92499  1.000 47.57633  ? 8   LYS A CE  1 
ATOM   73   N NZ  . LYS A 1 8   ? 2.61988   22.94255  -4.29805  1.000 63.80426  ? 8   LYS A NZ  1 
ATOM   74   N N   . ILE A 1 9   ? 6.06038   19.45930  1.60206   1.000 37.28935  ? 9   ILE A N   1 
ATOM   75   C CA  . ILE A 1 9   ? 7.03229   18.45940  2.04355   1.000 36.56160  ? 9   ILE A CA  1 
ATOM   76   C C   . ILE A 1 9   ? 6.52146   17.05355  1.74716   1.000 35.73116  ? 9   ILE A C   1 
ATOM   77   O O   . ILE A 1 9   ? 7.24809   16.21615  1.19583   1.000 36.04368  ? 9   ILE A O   1 
ATOM   78   C CB  . ILE A 1 9   ? 7.35500   18.64508  3.54097   1.000 35.23975  ? 9   ILE A CB  1 
ATOM   79   C CG1 . ILE A 1 9   ? 7.99662   20.00887  3.79238   1.000 34.85456  ? 9   ILE A CG1 1 
ATOM   80   C CG2 . ILE A 1 9   ? 8.28184   17.54873  4.02931   1.000 36.76562  ? 9   ILE A CG2 1 
ATOM   81   C CD1 . ILE A 1 9   ? 8.05196   20.38136  5.27580   1.000 38.56486  ? 9   ILE A CD1 1 
ATOM   82   N N   . TYR A 1 10  ? 5.25906   16.77736  2.09188   1.000 38.95741  ? 10  TYR A N   1 
ATOM   83   C CA  . TYR A 1 10  ? 4.67958   15.46529  1.81017   1.000 33.11489  ? 10  TYR A CA  1 
ATOM   84   C C   . TYR A 1 10  ? 4.72522   15.14570  0.32159   1.000 36.36152  ? 10  TYR A C   1 
ATOM   85   O O   . TYR A 1 10  ? 4.98354   14.00004  -0.06967  1.000 34.07360  ? 10  TYR A O   1 
ATOM   86   C CB  . TYR A 1 10  ? 3.23477   15.39684  2.31364   1.000 33.26420  ? 10  TYR A CB  1 
ATOM   87   C CG  . TYR A 1 10  ? 2.63434   14.00392  2.23155   1.000 39.32528  ? 10  TYR A CG  1 
ATOM   88   C CD1 . TYR A 1 10  ? 2.78260   13.10408  3.28712   1.000 37.58664  ? 10  TYR A CD1 1 
ATOM   89   C CD2 . TYR A 1 10  ? 1.92737   13.58456  1.10139   1.000 35.00007  ? 10  TYR A CD2 1 
ATOM   90   C CE1 . TYR A 1 10  ? 2.24647   11.82814  3.22643   1.000 34.83018  ? 10  TYR A CE1 1 
ATOM   91   C CE2 . TYR A 1 10  ? 1.38637   12.30589  1.02809   1.000 33.89932  ? 10  TYR A CE2 1 
ATOM   92   C CZ  . TYR A 1 10  ? 1.55272   11.43468  2.09745   1.000 38.41493  ? 10  TYR A CZ  1 
ATOM   93   O OH  . TYR A 1 10  ? 1.02423   10.16724  2.04595   1.000 41.20166  ? 10  TYR A OH  1 
ATOM   94   N N   . GLU A 1 11  ? 4.46280   16.14141  -0.52651  1.000 35.14533  ? 11  GLU A N   1 
ATOM   95   C CA  . GLU A 1 11  ? 4.47893   15.88529  -1.96282  1.000 40.84803  ? 11  GLU A CA  1 
ATOM   96   C C   . GLU A 1 11  ? 5.88353   15.57320  -2.46133  1.000 34.41920  ? 11  GLU A C   1 
ATOM   97   O O   . GLU A 1 11  ? 6.04720   14.72602  -3.34678  1.000 38.12327  ? 11  GLU A O   1 
ATOM   98   C CB  . GLU A 1 11  ? 3.87813   17.07151  -2.71893  1.000 39.46504  ? 11  GLU A CB  1 
ATOM   99   C CG  . GLU A 1 11  ? 2.36650   17.16653  -2.54800  1.000 47.32097  ? 11  GLU A CG  1 
ATOM   100  C CD  . GLU A 1 11  ? 1.77989   18.44027  -3.12008  1.000 51.58889  ? 11  GLU A CD  1 
ATOM   101  O OE1 . GLU A 1 11  ? 2.55637   19.31175  -3.56524  1.000 58.65357  ? 11  GLU A OE1 1 
ATOM   102  O OE2 . GLU A 1 11  ? 0.53726   18.56758  -3.12252  1.000 50.46269  ? 11  GLU A OE2 1 
ATOM   103  N N   . ILE A 1 12  ? 6.90560   16.22496  -1.89970  1.000 33.28619  ? 12  ILE A N   1 
ATOM   104  C CA  . ILE A 1 12  ? 8.28072   15.88798  -2.26020  1.000 34.19300  ? 12  ILE A CA  1 
ATOM   105  C C   . ILE A 1 12  ? 8.58722   14.43844  -1.89944  1.000 37.08528  ? 12  ILE A C   1 
ATOM   106  O O   . ILE A 1 12  ? 9.19205   13.70442  -2.69175  1.000 36.95604  ? 12  ILE A O   1 
ATOM   107  C CB  . ILE A 1 12  ? 9.26754   16.86704  -1.59648  1.000 38.11472  ? 12  ILE A CB  1 
ATOM   108  C CG1 . ILE A 1 12  ? 9.10092   18.26887  -2.19092  1.000 41.41903  ? 12  ILE A CG1 1 
ATOM   109  C CG2 . ILE A 1 12  ? 10.69957  16.37510  -1.75660  1.000 35.82225  ? 12  ILE A CG2 1 
ATOM   110  C CD1 . ILE A 1 12  ? 10.09302  19.28746  -1.67591  1.000 36.59600  ? 12  ILE A CD1 1 
ATOM   111  N N   . MET A 1 13  ? 8.15183   13.99479  -0.71295  1.000 34.65962  ? 13  MET A N   1 
ATOM   112  C CA  . MET A 1 13  ? 8.35393   12.60165  -0.32156  1.000 33.08482  ? 13  MET A CA  1 
ATOM   113  C C   . MET A 1 13  ? 7.75139   11.65169  -1.34647  1.000 35.22171  ? 13  MET A C   1 
ATOM   114  O O   . MET A 1 13  ? 8.41078   10.70285  -1.78781  1.000 30.80631  ? 13  MET A O   1 
ATOM   115  C CB  . MET A 1 13  ? 7.75009   12.33883  1.06341   1.000 32.99491  ? 13  MET A CB  1 
ATOM   116  C CG  . MET A 1 13  ? 7.81203   10.86482  1.48796   1.000 33.37026  ? 13  MET A CG  1 
ATOM   117  S SD  . MET A 1 13  ? 7.21696   10.52448  3.17729   1.000 41.60907  ? 13  MET A SD  1 
ATOM   118  C CE  . MET A 1 13  ? 5.44313   10.57536  2.95381   1.000 36.91185  ? 13  MET A CE  1 
ATOM   119  N N   . VAL A 1 14  ? 6.49689   11.89545  -1.73507  1.000 36.07334  ? 14  VAL A N   1 
ATOM   120  C CA  . VAL A 1 14  ? 5.82077   11.04287  -2.71015  1.000 37.30977  ? 14  VAL A CA  1 
ATOM   121  C C   . VAL A 1 14  ? 6.54647   11.07819  -4.04991  1.000 39.95093  ? 14  VAL A C   1 
ATOM   122  O O   . VAL A 1 14  ? 6.81193   10.03490  -4.66070  1.000 37.70605  ? 14  VAL A O   1 
ATOM   123  C CB  . VAL A 1 14  ? 4.35080   11.47428  -2.86120  1.000 41.15066  ? 14  VAL A CB  1 
ATOM   124  C CG1 . VAL A 1 14  ? 3.67703   10.68612  -3.97059  1.000 35.30416  ? 14  VAL A CG1 1 
ATOM   125  C CG2 . VAL A 1 14  ? 3.61402   11.29980  -1.54134  1.000 38.46446  ? 14  VAL A CG2 1 
ATOM   126  N N   . ARG A 1 15  ? 6.85707   12.28152  -4.53954  1.000 39.15311  ? 15  ARG A N   1 
ATOM   127  C CA  . ARG A 1 15  ? 7.51627   12.39741  -5.83826  1.000 41.45930  ? 15  ARG A CA  1 
ATOM   128  C C   . ARG A 1 15  ? 8.84591   11.65331  -5.84775  1.000 43.73933  ? 15  ARG A C   1 
ATOM   129  O O   . ARG A 1 15  ? 9.16629   10.95152  -6.81442  1.000 39.78117  ? 15  ARG A O   1 
ATOM   130  C CB  . ARG A 1 15  ? 7.72436   13.86771  -6.20297  1.000 37.02599  ? 15  ARG A CB  1 
ATOM   131  C CG  . ARG A 1 15  ? 8.35271   14.05521  -7.56984  1.000 53.61148  ? 15  ARG A CG  1 
ATOM   132  C CD  . ARG A 1 15  ? 8.64782   15.51383  -7.87612  1.000 60.88989  ? 15  ARG A CD  1 
ATOM   133  N NE  . ARG A 1 15  ? 9.68105   15.63326  -8.90045  1.000 72.44933  ? 15  ARG A NE  1 
ATOM   134  C CZ  . ARG A 1 15  ? 10.23928  16.77368  -9.28380  1.000 69.82096  ? 15  ARG A CZ  1 
ATOM   135  N NH1 . ARG A 1 15  ? 9.86847   17.93409  -8.76421  1.000 64.23024  ? 15  ARG A NH1 1 
ATOM   136  N NH2 . ARG A 1 15  ? 11.19814  16.74738  -10.20762 1.000 63.79232  ? 15  ARG A NH2 1 
ATOM   137  N N   . LEU A 1 16  ? 9.61961   11.77086  -4.76382  1.000 39.15340  ? 16  LEU A N   1 
ATOM   138  C CA  . LEU A 1 16  ? 10.90579  11.08344  -4.69216  1.000 39.86818  ? 16  LEU A CA  1 
ATOM   139  C C   . LEU A 1 16  ? 10.73724  9.57454   -4.82212  1.000 38.78061  ? 16  LEU A C   1 
ATOM   140  O O   . LEU A 1 16  ? 11.55595  8.90381   -5.46183  1.000 39.87087  ? 16  LEU A O   1 
ATOM   141  C CB  . LEU A 1 16  ? 11.62193  11.44072  -3.38691  1.000 39.34424  ? 16  LEU A CB  1 
ATOM   142  C CG  . LEU A 1 16  ? 12.23986  12.84049  -3.37200  1.000 39.04544  ? 16  LEU A CG  1 
ATOM   143  C CD1 . LEU A 1 16  ? 12.75831  13.19727  -1.99117  1.000 38.29307  ? 16  LEU A CD1 1 
ATOM   144  C CD2 . LEU A 1 16  ? 13.35229  12.93507  -4.40762  1.000 34.81259  ? 16  LEU A CD2 1 
ATOM   145  N N   . ASP A 1 17  ? 9.67380   9.02068   -4.23859  1.000 39.09759  ? 17  ASP A N   1 
ATOM   146  C CA  . ASP A 1 17  ? 9.46861   7.57987   -4.34572  1.000 42.88180  ? 17  ASP A CA  1 
ATOM   147  C C   . ASP A 1 17  ? 9.04279   7.18139   -5.75345  1.000 45.62982  ? 17  ASP A C   1 
ATOM   148  O O   . ASP A 1 17  ? 9.44786   6.12552   -6.25602  1.000 44.87297  ? 17  ASP A O   1 
ATOM   149  C CB  . ASP A 1 17  ? 8.43278   7.10714   -3.33011  1.000 38.79879  ? 17  ASP A CB  1 
ATOM   150  C CG  . ASP A 1 17  ? 8.10517   5.63628   -3.49079  1.000 43.82426  ? 17  ASP A CG  1 
ATOM   151  O OD1 . ASP A 1 17  ? 9.00825   4.79917   -3.26984  1.000 45.18722  ? 17  ASP A OD1 1 
ATOM   152  O OD2 . ASP A 1 17  ? 6.95253   5.31831   -3.85197  1.000 43.93583  ? 17  ASP A OD2 1 
ATOM   153  N N   . GLU A 1 18  ? 8.21543   8.00574   -6.40036  1.000 44.12793  ? 18  GLU A N   1 
ATOM   154  C CA  . GLU A 1 18  ? 7.76609   7.68960   -7.75234  1.000 49.20420  ? 18  GLU A CA  1 
ATOM   155  C C   . GLU A 1 18  ? 8.91260   7.73677   -8.75274  1.000 44.64561  ? 18  GLU A C   1 
ATOM   156  O O   . GLU A 1 18  ? 8.88310   7.02480   -9.76337  1.000 50.77355  ? 18  GLU A O   1 
ATOM   157  C CB  . GLU A 1 18  ? 6.65600   8.65291   -8.17537  1.000 50.43421  ? 18  GLU A CB  1 
ATOM   158  C CG  . GLU A 1 18  ? 5.40868   8.56316   -7.31844  1.000 48.68032  ? 18  GLU A CG  1 
ATOM   159  C CD  . GLU A 1 18  ? 4.35872   9.58337   -7.70866  1.000 57.88329  ? 18  GLU A CD  1 
ATOM   160  O OE1 . GLU A 1 18  ? 4.65858   10.44389  -8.56721  1.000 56.31040  ? 18  GLU A OE1 1 
ATOM   161  O OE2 . GLU A 1 18  ? 3.23802   9.52182   -7.15314  1.000 55.80140  ? 18  GLU A OE2 1 
ATOM   162  N N   . GLU A 1 19  ? 9.92336   8.56014   -8.49133  1.000 43.04080  ? 19  GLU A N   1 
ATOM   163  C CA  . GLU A 1 19  ? 11.06644  8.70643   -9.37870  1.000 50.29321  ? 19  GLU A CA  1 
ATOM   164  C C   . GLU A 1 19  ? 12.23070  7.79901   -8.99490  1.000 52.13523  ? 19  GLU A C   1 
ATOM   165  O O   . GLU A 1 19  ? 13.32077  7.93536   -9.55683  1.000 56.25527  ? 19  GLU A O   1 
ATOM   166  C CB  . GLU A 1 19  ? 11.50951  10.17084  -9.41099  1.000 43.40110  ? 19  GLU A CB  1 
ATOM   167  C CG  . GLU A 1 19  ? 10.46252  11.09119  -10.03149 1.000 58.63401  ? 19  GLU A CG  1 
ATOM   168  C CD  . GLU A 1 19  ? 10.80526  12.56678  -9.90686  1.000 68.40343  ? 19  GLU A CD  1 
ATOM   169  O OE1 . GLU A 1 19  ? 11.84237  12.89150  -9.28848  1.000 69.06751  ? 19  GLU A OE1 1 
ATOM   170  O OE2 . GLU A 1 19  ? 10.03228  13.40190  -10.42908 1.000 61.96625  ? 19  GLU A OE2 1 
ATOM   171  N N   . GLY A 1 20  ? 12.02451  6.87569   -8.05616  1.000 52.93860  ? 20  GLY A N   1 
ATOM   172  C CA  . GLY A 1 20  ? 13.04151  5.91651   -7.68504  1.000 44.34713  ? 20  GLY A CA  1 
ATOM   173  C C   . GLY A 1 20  ? 14.01234  6.37211   -6.61929  1.000 50.47303  ? 20  GLY A C   1 
ATOM   174  O O   . GLY A 1 20  ? 14.91413  5.60288   -6.25981  1.000 59.62178  ? 20  GLY A O   1 
ATOM   175  N N   . HIS A 1 21  ? 13.86432  7.59048   -6.10062  1.000 44.75743  ? 21  HIS A N   1 
ATOM   176  C CA  . HIS A 1 21  ? 14.74325  8.09287   -5.04346  1.000 47.12435  ? 21  HIS A CA  1 
ATOM   177  C C   . HIS A 1 21  ? 14.17835  7.69370   -3.67892  1.000 42.63638  ? 21  HIS A C   1 
ATOM   178  O O   . HIS A 1 21  ? 13.77798  8.51982   -2.85605  1.000 42.88635  ? 21  HIS A O   1 
ATOM   179  C CB  . HIS A 1 21  ? 14.91498  9.60038   -5.16631  1.000 45.04400  ? 21  HIS A CB  1 
ATOM   180  C CG  . HIS A 1 21  ? 15.42165  10.03832  -6.50410  1.000 51.60089  ? 21  HIS A CG  1 
ATOM   181  N ND1 . HIS A 1 21  ? 16.12923  9.20249   -7.34091  1.000 59.66023  ? 21  HIS A ND1 1 
ATOM   182  C CD2 . HIS A 1 21  ? 15.31137  11.21921  -7.15730  1.000 52.48807  ? 21  HIS A CD2 1 
ATOM   183  C CE1 . HIS A 1 21  ? 16.43637  9.85050   -8.45084  1.000 53.88341  ? 21  HIS A CE1 1 
ATOM   184  N NE2 . HIS A 1 21  ? 15.95320  11.07670  -8.36374  1.000 55.67087  ? 21  HIS A NE2 1 
ATOM   185  N N   . GLY A 1 22  ? 14.16061  6.38007   -3.45010  1.000 39.24620  ? 22  GLY A N   1 
ATOM   186  C CA  . GLY A 1 22  ? 13.57637  5.86298   -2.22263  1.000 44.29830  ? 22  GLY A CA  1 
ATOM   187  C C   . GLY A 1 22  ? 14.32659  6.30004   -0.97731  1.000 43.51101  ? 22  GLY A C   1 
ATOM   188  O O   . GLY A 1 22  ? 13.71736  6.72834   0.00872   1.000 37.24853  ? 22  GLY A O   1 
ATOM   189  N N   . GLU A 1 23  ? 15.65787  6.20419   -1.00526  1.000 39.36387  ? 23  GLU A N   1 
ATOM   190  C CA  . GLU A 1 23  ? 16.45530  6.59663   0.15311   1.000 40.80443  ? 23  GLU A CA  1 
ATOM   191  C C   . GLU A 1 23  ? 16.21736  8.05672   0.52234   1.000 42.45597  ? 23  GLU A C   1 
ATOM   192  O O   . GLU A 1 23  ? 16.03406  8.38727   1.70079   1.000 38.03054  ? 23  GLU A O   1 
ATOM   193  C CB  . GLU A 1 23  ? 17.93598  6.34409   -0.12946  1.000 41.63992  ? 23  GLU A CB  1 
ATOM   194  C CG  . GLU A 1 23  ? 18.82968  6.40502   1.08391   1.000 42.18918  ? 23  GLU A CG  1 
ATOM   195  C CD  . GLU A 1 23  ? 20.21093  5.84469   0.80152   1.000 50.85784  ? 23  GLU A CD  1 
ATOM   196  O OE1 . GLU A 1 23  ? 20.50876  5.57137   -0.38079  1.000 53.04740  ? 23  GLU A OE1 1 
ATOM   197  O OE2 . GLU A 1 23  ? 20.99774  5.67434   1.75728   1.000 53.54154  ? 23  GLU A OE2 1 
ATOM   198  N N   . ALA A 1 24  ? 16.20496  8.94755   -0.47078  1.000 38.02071  ? 24  ALA A N   1 
ATOM   199  C CA  . ALA A 1 24  ? 15.92679  10.35153  -0.18404  1.000 37.64677  ? 24  ALA A CA  1 
ATOM   200  C C   . ALA A 1 24  ? 14.49024  10.55952  0.28487   1.000 39.49946  ? 24  ALA A C   1 
ATOM   201  O O   . ALA A 1 24  ? 14.21725  11.48627  1.05845   1.000 37.11313  ? 24  ALA A O   1 
ATOM   202  C CB  . ALA A 1 24  ? 16.21292  11.20301  -1.41934  1.000 39.40536  ? 24  ALA A CB  1 
ATOM   203  N N   . SER A 1 25  ? 13.56027  9.71994   -0.17532  1.000 37.65406  ? 25  SER A N   1 
ATOM   204  C CA  . SER A 1 25  ? 12.18905  9.79936   0.31965   1.000 39.25826  ? 25  SER A CA  1 
ATOM   205  C C   . SER A 1 25  ? 12.12665  9.51629   1.81848   1.000 40.27983  ? 25  SER A C   1 
ATOM   206  O O   . SER A 1 25  ? 11.37189  10.17131  2.54829   1.000 35.52459  ? 25  SER A O   1 
ATOM   207  C CB  . SER A 1 25  ? 11.29625  8.82660   -0.45459  1.000 35.55309  ? 25  SER A CB  1 
ATOM   208  O OG  . SER A 1 25  ? 9.93839   8.95968   -0.07734  1.000 37.54084  ? 25  SER A OG  1 
ATOM   209  N N   . LEU A 1 26  ? 12.92706  8.55622   2.29584   1.000 37.44844  ? 26  LEU A N   1 
ATOM   210  C CA  . LEU A 1 26  ? 12.94206  8.23142   3.72124   1.000 36.85820  ? 26  LEU A CA  1 
ATOM   211  C C   . LEU A 1 26  ? 13.44767  9.40094   4.55166   1.000 38.64612  ? 26  LEU A C   1 
ATOM   212  O O   . LEU A 1 26  ? 12.95107  9.64548   5.65737   1.000 41.10060  ? 26  LEU A O   1 
ATOM   213  C CB  . LEU A 1 26  ? 13.80745  6.99680   3.97656   1.000 34.11500  ? 26  LEU A CB  1 
ATOM   214  C CG  . LEU A 1 26  ? 13.29442  5.66104   3.44145   1.000 37.45741  ? 26  LEU A CG  1 
ATOM   215  C CD1 . LEU A 1 26  ? 14.34383  4.58184   3.62572   1.000 38.88740  ? 26  LEU A CD1 1 
ATOM   216  C CD2 . LEU A 1 26  ? 12.00115  5.28259   4.14382   1.000 45.18199  ? 26  LEU A CD2 1 
ATOM   217  N N   . MET A 1 27  ? 14.44024  10.13124  4.04160   1.000 38.11338  ? 27  MET A N   1 
ATOM   218  C CA  . MET A 1 27  ? 14.96669  11.26684  4.78922   1.000 34.46157  ? 27  MET A CA  1 
ATOM   219  C C   . MET A 1 27  ? 13.93135  12.38032  4.89276   1.000 38.00462  ? 27  MET A C   1 
ATOM   220  O O   . MET A 1 27  ? 13.81549  13.03205  5.93772   1.000 40.53584  ? 27  MET A O   1 
ATOM   221  C CB  . MET A 1 27  ? 16.25631  11.76550  4.13779   1.000 44.22585  ? 27  MET A CB  1 
ATOM   222  C CG  . MET A 1 27  ? 17.33008  10.68545  4.02539   1.000 48.39248  ? 27  MET A CG  1 
ATOM   223  S SD  . MET A 1 27  ? 18.84805  11.23865  3.22557   1.000 49.06165  ? 27  MET A SD  1 
ATOM   224  C CE  . MET A 1 27  ? 19.17322  12.74594  4.14383   1.000 42.57578  ? 27  MET A CE  1 
ATOM   225  N N   . VAL A 1 28  ? 13.15565  12.60292  3.82708   1.000 39.01524  ? 28  VAL A N   1 
ATOM   226  C CA  . VAL A 1 28  ? 12.07134  13.57909  3.90481   1.000 36.38584  ? 28  VAL A CA  1 
ATOM   227  C C   . VAL A 1 28  ? 10.98463  13.09484  4.85933   1.000 36.09360  ? 28  VAL A C   1 
ATOM   228  O O   . VAL A 1 28  ? 10.36180  13.89956  5.56411   1.000 34.90714  ? 28  VAL A O   1 
ATOM   229  C CB  . VAL A 1 28  ? 11.50776  13.87246  2.49947   1.000 37.43279  ? 28  VAL A CB  1 
ATOM   230  C CG1 . VAL A 1 28  ? 10.40826  14.91961  2.57138   1.000 27.49999  ? 28  VAL A CG1 1 
ATOM   231  C CG2 . VAL A 1 28  ? 12.62058  14.33484  1.57245   1.000 28.71799  ? 28  VAL A CG2 1 
ATOM   232  N N   . SER A 1 29  ? 10.73865  11.78250  4.89799   1.000 34.37291  ? 29  SER A N   1 
ATOM   233  C CA  . SER A 1 29  ? 9.80082   11.22197  5.86671   1.000 35.33484  ? 29  SER A CA  1 
ATOM   234  C C   . SER A 1 29  ? 10.18679  11.59786  7.29328   1.000 40.28491  ? 29  SER A C   1 
ATOM   235  O O   . SER A 1 29  ? 9.32968   11.99237  8.09485   1.000 39.38633  ? 29  SER A O   1 
ATOM   236  C CB  . SER A 1 29  ? 9.74489   9.70257   5.71081   1.000 37.55872  ? 29  SER A CB  1 
ATOM   237  O OG  . SER A 1 29  ? 8.75388   9.13547   6.55268   1.000 49.68447  ? 29  SER A OG  1 
ATOM   238  N N   . ASP A 1 30  ? 11.47856  11.49462  7.62368   1.000 38.43051  ? 30  ASP A N   1 
ATOM   239  C CA  . ASP A 1 30  ? 11.93797  11.87682  8.95542   1.000 36.73413  ? 30  ASP A CA  1 
ATOM   240  C C   . ASP A 1 30  ? 11.65555  13.34493  9.24556   1.000 41.42707  ? 30  ASP A C   1 
ATOM   241  O O   . ASP A 1 30  ? 11.34049  13.70342  10.38666  1.000 40.48220  ? 30  ASP A O   1 
ATOM   242  C CB  . ASP A 1 30  ? 13.43384  11.58749  9.10469   1.000 37.67962  ? 30  ASP A CB  1 
ATOM   243  C CG  . ASP A 1 30  ? 13.75608  10.10195  9.04712   1.000 44.69977  ? 30  ASP A CG  1 
ATOM   244  O OD1 . ASP A 1 30  ? 12.84530  9.27597   9.28245   1.000 44.39563  ? 30  ASP A OD1 1 
ATOM   245  O OD2 . ASP A 1 30  ? 14.92830  9.76206   8.77369   1.000 39.49527  ? 30  ASP A OD2 1 
ATOM   246  N N   . LEU A 1 31  ? 11.76305  14.20875  8.23356   1.000 37.13299  ? 31  LEU A N   1 
ATOM   247  C CA  . LEU A 1 31  ? 11.44627  15.61917  8.43973   1.000 38.73364  ? 31  LEU A CA  1 
ATOM   248  C C   . LEU A 1 31  ? 9.97188   15.81002  8.77093   1.000 37.62300  ? 31  LEU A C   1 
ATOM   249  O O   . LEU A 1 31  ? 9.62748   16.62329  9.63595   1.000 39.40970  ? 31  LEU A O   1 
ATOM   250  C CB  . LEU A 1 31  ? 11.82683  16.43514  7.20384   1.000 38.49441  ? 31  LEU A CB  1 
ATOM   251  C CG  . LEU A 1 31  ? 11.45838  17.92480  7.19389   1.000 42.16553  ? 31  LEU A CG  1 
ATOM   252  C CD1 . LEU A 1 31  ? 12.09811  18.66595  8.34987   1.000 39.36778  ? 31  LEU A CD1 1 
ATOM   253  C CD2 . LEU A 1 31  ? 11.85539  18.56024  5.86350   1.000 44.72792  ? 31  LEU A CD2 1 
ATOM   254  N N   . ILE A 1 32  ? 9.08832   15.06935  8.09396   1.000 34.90960  ? 32  ILE A N   1 
ATOM   255  C CA  . ILE A 1 32  ? 7.66276   15.15063  8.39910   1.000 36.10804  ? 32  ILE A CA  1 
ATOM   256  C C   . ILE A 1 32  ? 7.40872   14.79474  9.86014   1.000 37.13942  ? 32  ILE A C   1 
ATOM   257  O O   . ILE A 1 32  ? 6.66619   15.49315  10.56120  1.000 40.78025  ? 32  ILE A O   1 
ATOM   258  C CB  . ILE A 1 32  ? 6.85388   14.24899  7.44647   1.000 35.06037  ? 32  ILE A CB  1 
ATOM   259  C CG1 . ILE A 1 32  ? 6.91870   14.78568  6.01331   1.000 36.45818  ? 32  ILE A CG1 1 
ATOM   260  C CG2 . ILE A 1 32  ? 5.40678   14.14570  7.90884   1.000 29.70909  ? 32  ILE A CG2 1 
ATOM   261  C CD1 . ILE A 1 32  ? 6.23272   13.89800  4.99668   1.000 36.70697  ? 32  ILE A CD1 1 
ATOM   262  N N   . TYR A 1 33  ? 8.02491   13.71107  10.34640  1.000 37.59410  ? 33  TYR A N   1 
ATOM   263  C CA  . TYR A 1 33  ? 7.85509   13.33330  11.74863  1.000 40.33849  ? 33  TYR A CA  1 
ATOM   264  C C   . TYR A 1 33  ? 8.28863   14.45717  12.67940  1.000 38.34476  ? 33  TYR A C   1 
ATOM   265  O O   . TYR A 1 33  ? 7.54403   14.84905  13.58467  1.000 38.52808  ? 33  TYR A O   1 
ATOM   266  C CB  . TYR A 1 33  ? 8.63792   12.05941  12.07004  1.000 39.15846  ? 33  TYR A CB  1 
ATOM   267  C CG  . TYR A 1 33  ? 8.77635   11.83036  13.55670  1.000 41.00809  ? 33  TYR A CG  1 
ATOM   268  C CD1 . TYR A 1 33  ? 7.72670   11.29384  14.29972  1.000 46.64321  ? 33  TYR A CD1 1 
ATOM   269  C CD2 . TYR A 1 33  ? 9.94903   12.17343  14.22862  1.000 41.35634  ? 33  TYR A CD2 1 
ATOM   270  C CE1 . TYR A 1 33  ? 7.84670   11.09799  15.67314  1.000 44.51409  ? 33  TYR A CE1 1 
ATOM   271  C CE2 . TYR A 1 33  ? 10.07400  11.98281  15.59339  1.000 40.79631  ? 33  TYR A CE2 1 
ATOM   272  C CZ  . TYR A 1 33  ? 9.02323   11.44284  16.30963  1.000 41.32898  ? 33  TYR A CZ  1 
ATOM   273  O OH  . TYR A 1 33  ? 9.14930   11.25061  17.66802  1.000 45.66022  ? 33  TYR A OH  1 
ATOM   274  N N   . GLU A 1 34  ? 9.49806   14.98684  12.47422  1.000 40.24650  ? 34  GLU A N   1 
ATOM   275  C CA  . GLU A 1 34  ? 10.00545  16.02030  13.37039  1.000 43.84095  ? 34  GLU A CA  1 
ATOM   276  C C   . GLU A 1 34  ? 9.16303   17.28641  13.30372  1.000 46.66164  ? 34  GLU A C   1 
ATOM   277  O O   . GLU A 1 34  ? 8.95662   17.94698  14.32908  1.000 49.80512  ? 34  GLU A O   1 
ATOM   278  C CB  . GLU A 1 34  ? 11.46428  16.33935  13.04231  1.000 47.60253  ? 34  GLU A CB  1 
ATOM   279  C CG  . GLU A 1 34  ? 12.14900  17.18740  14.11051  1.000 65.27652  ? 34  GLU A CG  1 
ATOM   280  C CD  . GLU A 1 34  ? 13.52774  17.67996  13.69755  1.000 78.80348  ? 34  GLU A CD  1 
ATOM   281  O OE1 . GLU A 1 34  ? 13.96657  17.36965  12.56649  1.000 76.79153  ? 34  GLU A OE1 1 
ATOM   282  O OE2 . GLU A 1 34  ? 14.16930  18.38382  14.51006  1.000 80.24175  ? 34  GLU A OE2 1 
ATOM   283  N N   . PHE A 1 35  ? 8.66650   17.63183  12.11397  1.000 47.88707  ? 35  PHE A N   1 
ATOM   284  C CA  . PHE A 1 35  ? 7.86177   18.83848  11.95110  1.000 45.94072  ? 35  PHE A CA  1 
ATOM   285  C C   . PHE A 1 35  ? 6.56192   18.74766  12.74286  1.000 44.47311  ? 35  PHE A C   1 
ATOM   286  O O   . PHE A 1 35  ? 6.21661   19.66155  13.50277  1.000 49.14723  ? 35  PHE A O   1 
ATOM   287  C CB  . PHE A 1 35  ? 7.57742   19.06248  10.46401  1.000 45.86646  ? 35  PHE A CB  1 
ATOM   288  C CG  . PHE A 1 35  ? 6.84965   20.33701  10.16681  1.000 47.46579  ? 35  PHE A CG  1 
ATOM   289  C CD1 . PHE A 1 35  ? 6.95462   21.43282  11.01256  1.000 55.51658  ? 35  PHE A CD1 1 
ATOM   290  C CD2 . PHE A 1 35  ? 6.05302   20.44038  9.03996   1.000 50.12151  ? 35  PHE A CD2 1 
ATOM   291  C CE1 . PHE A 1 35  ? 6.27568   22.60535  10.73328  1.000 61.33578  ? 35  PHE A CE1 1 
ATOM   292  C CE2 . PHE A 1 35  ? 5.37398   21.61104  8.75029   1.000 51.33852  ? 35  PHE A CE2 1 
ATOM   293  C CZ  . PHE A 1 35  ? 5.48288   22.69296  9.59505   1.000 57.57828  ? 35  PHE A CZ  1 
ATOM   294  N N   . MET A 1 36  ? 5.81999   17.65567  12.56773  1.000 43.24492  ? 36  MET A N   1 
ATOM   295  C CA  . MET A 1 36  ? 4.53696   17.52338  13.24413  1.000 51.10134  ? 36  MET A CA  1 
ATOM   296  C C   . MET A 1 36  ? 4.69254   17.27594  14.73555  1.000 50.50583  ? 36  MET A C   1 
ATOM   297  O O   . MET A 1 36  ? 3.74253   17.49760  15.49079  1.000 52.86973  ? 36  MET A O   1 
ATOM   298  C CB  . MET A 1 36  ? 3.72899   16.40241  12.60226  1.000 40.05515  ? 36  MET A CB  1 
ATOM   299  C CG  . MET A 1 36  ? 3.44294   16.66434  11.13739  1.000 42.19909  ? 36  MET A CG  1 
ATOM   300  S SD  . MET A 1 36  ? 2.30898   15.46119  10.46114  1.000 57.46394  ? 36  MET A SD  1 
ATOM   301  C CE  . MET A 1 36  ? 0.80645   15.91172  11.32913  1.000 52.65256  ? 36  MET A CE  1 
ATOM   302  N N   . LYS A 1 37  ? 5.86764   16.82581  15.17136  1.000 47.88582  ? 37  LYS A N   1 
ATOM   303  C CA  . LYS A 1 37  ? 6.13454   16.67411  16.59250  1.000 53.29335  ? 37  LYS A CA  1 
ATOM   304  C C   . LYS A 1 37  ? 6.24554   18.01905  17.29625  1.000 58.78528  ? 37  LYS A C   1 
ATOM   305  O O   . LYS A 1 37  ? 6.18765   18.06642  18.52794  1.000 59.94202  ? 37  LYS A O   1 
ATOM   306  C CB  . LYS A 1 37  ? 7.41517   15.86838  16.79300  1.000 46.80274  ? 37  LYS A CB  1 
ATOM   307  C CG  . LYS A 1 37  ? 7.46737   15.10897  18.08582  1.000 55.63745  ? 37  LYS A CG  1 
ATOM   308  C CD  . LYS A 1 37  ? 6.41067   14.02774  18.12751  1.000 53.97513  ? 37  LYS A CD  1 
ATOM   309  C CE  . LYS A 1 37  ? 6.44709   13.31547  19.47150  1.000 50.86006  ? 37  LYS A CE  1 
ATOM   310  N NZ  . LYS A 1 37  ? 5.41752   12.24592  19.56373  1.000 50.27700  ? 37  LYS A NZ  1 
ATOM   311  N N   . ARG A 1 38  ? 6.40149   19.10848  16.54655  1.000 62.42088  ? 38  ARG A N   1 
ATOM   312  C CA  . ARG A 1 38  ? 6.49207   20.43543  17.13431  1.000 66.95919  ? 38  ARG A CA  1 
ATOM   313  C C   . ARG A 1 38  ? 5.09925   20.96050  17.47350  1.000 80.66581  ? 38  ARG A C   1 
ATOM   314  O O   . ARG A 1 38  ? 4.08591   20.27541  17.30496  1.000 86.85041  ? 38  ARG A O   1 
ATOM   315  C CB  . ARG A 1 38  ? 7.22100   21.38804  16.19059  1.000 63.48100  ? 38  ARG A CB  1 
ATOM   316  C CG  . ARG A 1 38  ? 8.70400   21.11077  16.06251  1.000 61.65685  ? 38  ARG A CG  1 
ATOM   317  C CD  . ARG A 1 38  ? 9.52136   22.03531  16.94550  1.000 61.57511  ? 38  ARG A CD  1 
ATOM   318  N NE  . ARG A 1 38  ? 9.27582   23.43890  16.63384  1.000 65.11111  ? 38  ARG A NE  1 
ATOM   319  C CZ  . ARG A 1 38  ? 9.93668   24.45381  17.17431  1.000 64.27967  ? 38  ARG A CZ  1 
ATOM   320  N NH1 . ARG A 1 38  ? 10.91476  24.25565  18.04379  1.000 56.48406  ? 38  ARG A NH1 1 
ATOM   321  N NH2 . ARG A 1 38  ? 9.60728   25.69822  16.83403  1.000 57.47597  ? 38  ARG A NH2 1 
ATOM   322  N N   . ASP A 1 39  ? 5.05278   22.19705  17.96214  1.000 89.22739  ? 39  ASP A N   1 
ATOM   323  C CA  . ASP A 1 39  ? 3.79975   22.83293  18.35766  1.000 95.92315  ? 39  ASP A CA  1 
ATOM   324  C C   . ASP A 1 39  ? 2.81232   22.89858  17.19382  1.000 101.19243 ? 39  ASP A C   1 
ATOM   325  O O   . ASP A 1 39  ? 1.59712   22.86564  17.39659  1.000 96.49521  ? 39  ASP A O   1 
ATOM   326  C CB  . ASP A 1 39  ? 4.06178   24.24135  18.90016  1.000 94.51929  ? 39  ASP A CB  1 
ATOM   327  C CG  . ASP A 1 39  ? 4.68858   25.16063  17.86336  1.000 102.88141 ? 39  ASP A CG  1 
ATOM   328  O OD1 . ASP A 1 39  ? 5.75485   24.80941  17.31171  1.000 96.57623  ? 39  ASP A OD1 1 
ATOM   329  O OD2 . ASP A 1 39  ? 4.10493   26.23103  17.58987  1.000 103.39766 ? 39  ASP A OD2 1 
ATOM   330  O OXT . ASP A 1 39  ? 3.20726   22.97714  16.02820  1.000 101.81982 ? 39  ASP A OXT 1 
ATOM   331  N N   . ASN B 2 2   ? 11.27367  -31.06242 23.78845  1.000 102.81285 ? 334 ASN B N   1 
ATOM   332  C CA  . ASN B 2 2   ? 10.57205  -30.00924 24.51360  1.000 102.63289 ? 334 ASN B CA  1 
ATOM   333  C C   . ASN B 2 2   ? 11.39558  -28.72368 24.57451  1.000 96.51955  ? 334 ASN B C   1 
ATOM   334  O O   . ASN B 2 2   ? 11.26078  -27.93469 25.50982  1.000 94.54012  ? 334 ASN B O   1 
ATOM   335  C CB  . ASN B 2 2   ? 10.22008  -30.47746 25.92892  1.000 103.47304 ? 334 ASN B CB  1 
ATOM   336  C CG  . ASN B 2 2   ? 11.41147  -31.06800 26.66344  1.000 105.56382 ? 334 ASN B CG  1 
ATOM   337  O OD1 . ASN B 2 2   ? 12.17300  -30.35241 27.31457  1.000 104.63517 ? 334 ASN B OD1 1 
ATOM   338  N ND2 . ASN B 2 2   ? 11.57426  -32.38263 26.56508  1.000 107.33075 ? 334 ASN B ND2 1 
ATOM   339  N N   . LEU B 2 3   ? 12.24801  -28.51712 23.57450  1.000 93.96434  ? 335 LEU B N   1 
ATOM   340  C CA  . LEU B 2 3   ? 13.04305  -27.30054 23.50067  1.000 92.51458  ? 335 LEU B CA  1 
ATOM   341  C C   . LEU B 2 3   ? 12.19371  -26.13828 22.99776  1.000 89.20102  ? 335 LEU B C   1 
ATOM   342  O O   . LEU B 2 3   ? 11.25301  -26.31910 22.21883  1.000 85.26451  ? 335 LEU B O   1 
ATOM   343  C CB  . LEU B 2 3   ? 14.25304  -27.50080 22.58695  1.000 84.33706  ? 335 LEU B CB  1 
ATOM   344  N N   . CYS B 2 4   ? 12.53436  -24.93556 23.45444  1.000 86.19818  ? 336 CYS B N   1 
ATOM   345  C CA  . CYS B 2 4   ? 11.75637  -23.76190 23.08508  1.000 83.76883  ? 336 CYS B CA  1 
ATOM   346  C C   . CYS B 2 4   ? 11.97775  -23.42520 21.61093  1.000 77.01660  ? 336 CYS B C   1 
ATOM   347  O O   . CYS B 2 4   ? 13.10156  -23.52822 21.11203  1.000 73.66018  ? 336 CYS B O   1 
ATOM   348  C CB  . CYS B 2 4   ? 12.12907  -22.56335 23.95729  1.000 81.70337  ? 336 CYS B CB  1 
ATOM   349  S SG  . CYS B 2 4   ? 11.60660  -22.70047 25.68796  1.000 92.49662  ? 336 CYS B SG  1 
ATOM   350  N N   . PRO B 2 5   ? 10.92057  -23.00649 20.89576  1.000 73.12380  ? 337 PRO B N   1 
ATOM   351  C CA  . PRO B 2 5   ? 11.01674  -22.75557 19.44136  1.000 75.78867  ? 337 PRO B CA  1 
ATOM   352  C C   . PRO B 2 5   ? 11.61344  -21.39530 19.09155  1.000 73.23152  ? 337 PRO B C   1 
ATOM   353  O O   . PRO B 2 5   ? 11.01868  -20.61126 18.34769  1.000 78.42182  ? 337 PRO B O   1 
ATOM   354  C CB  . PRO B 2 5   ? 9.56320   -22.88063 18.98623  1.000 72.45795  ? 337 PRO B CB  1 
ATOM   355  C CG  . PRO B 2 5   ? 8.71896   -22.63036 20.21272  1.000 70.03732  ? 337 PRO B CG  1 
ATOM   356  C CD  . PRO B 2 5   ? 9.60569   -22.62480 21.42672  1.000 74.88900  ? 337 PRO B CD  1 
ATOM   357  N N   . PHE B 2 6   ? 12.80238  -21.11097 19.62623  1.000 74.09594  ? 338 PHE B N   1 
ATOM   358  C CA  . PHE B 2 6   ? 13.51949  -19.90008 19.24509  1.000 76.90747  ? 338 PHE B CA  1 
ATOM   359  C C   . PHE B 2 6   ? 13.97125  -19.93109 17.79102  1.000 75.99025  ? 338 PHE B C   1 
ATOM   360  O O   . PHE B 2 6   ? 14.22218  -18.87005 17.20997  1.000 73.88822  ? 338 PHE B O   1 
ATOM   361  C CB  . PHE B 2 6   ? 14.73289  -19.68938 20.15293  1.000 73.23642  ? 338 PHE B CB  1 
ATOM   362  C CG  . PHE B 2 6   ? 14.39521  -19.12095 21.49927  1.000 78.42563  ? 338 PHE B CG  1 
ATOM   363  C CD1 . PHE B 2 6   ? 13.22768  -18.40114 21.69293  1.000 78.72362  ? 338 PHE B CD1 1 
ATOM   364  C CD2 . PHE B 2 6   ? 15.25091  -19.30223 22.57405  1.000 84.86036  ? 338 PHE B CD2 1 
ATOM   365  C CE1 . PHE B 2 6   ? 12.92052  -17.87383 22.93639  1.000 75.27756  ? 338 PHE B CE1 1 
ATOM   366  C CE2 . PHE B 2 6   ? 14.94758  -18.77852 23.81694  1.000 78.28890  ? 338 PHE B CE2 1 
ATOM   367  C CZ  . PHE B 2 6   ? 13.78055  -18.06568 23.99800  1.000 74.56175  ? 338 PHE B CZ  1 
ATOM   368  N N   . ASP B 2 7   ? 14.08390  -21.11921 17.19322  1.000 78.82269  ? 339 ASP B N   1 
ATOM   369  C CA  . ASP B 2 7   ? 14.51094  -21.20536 15.80132  1.000 76.89413  ? 339 ASP B CA  1 
ATOM   370  C C   . ASP B 2 7   ? 13.42743  -20.69189 14.85954  1.000 75.82186  ? 339 ASP B C   1 
ATOM   371  O O   . ASP B 2 7   ? 13.73139  -20.05802 13.84224  1.000 73.92859  ? 339 ASP B O   1 
ATOM   372  C CB  . ASP B 2 7   ? 14.89181  -22.64629 15.46144  1.000 80.37364  ? 339 ASP B CB  1 
ATOM   373  C CG  . ASP B 2 7   ? 15.60529  -22.76241 14.12831  1.000 87.91996  ? 339 ASP B CG  1 
ATOM   374  O OD1 . ASP B 2 7   ? 16.75330  -22.28062 14.02316  1.000 92.12228  ? 339 ASP B OD1 1 
ATOM   375  O OD2 . ASP B 2 7   ? 15.01957  -23.33535 13.18528  1.000 88.11266  ? 339 ASP B OD2 1 
ATOM   376  N N   . GLU B 2 8   ? 12.15759  -20.94946 15.18280  1.000 73.57773  ? 340 GLU B N   1 
ATOM   377  C CA  . GLU B 2 8   ? 11.05332  -20.43538 14.38073  1.000 74.03118  ? 340 GLU B CA  1 
ATOM   378  C C   . GLU B 2 8   ? 10.87745  -18.93036 14.51763  1.000 75.70560  ? 340 GLU B C   1 
ATOM   379  O O   . GLU B 2 8   ? 10.12738  -18.33841 13.73395  1.000 73.65937  ? 340 GLU B O   1 
ATOM   380  C CB  . GLU B 2 8   ? 9.74582   -21.13334 14.76389  1.000 75.94633  ? 340 GLU B CB  1 
ATOM   381  C CG  . GLU B 2 8   ? 9.67118   -22.60441 14.38146  1.000 85.11195  ? 340 GLU B CG  1 
ATOM   382  C CD  . GLU B 2 8   ? 10.37033  -23.51822 15.37476  1.000 90.11719  ? 340 GLU B CD  1 
ATOM   383  O OE1 . GLU B 2 8   ? 11.17939  -23.02070 16.18753  1.000 83.89116  ? 340 GLU B OE1 1 
ATOM   384  O OE2 . GLU B 2 8   ? 10.10306  -24.73915 15.34339  1.000 94.64344  ? 340 GLU B OE2 1 
ATOM   385  N N   . VAL B 2 9   ? 11.53963  -18.30434 15.48783  1.000 69.40071  ? 341 VAL B N   1 
ATOM   386  C CA  . VAL B 2 9   ? 11.42281  -16.86903 15.70825  1.000 69.31116  ? 341 VAL B CA  1 
ATOM   387  C C   . VAL B 2 9   ? 12.52488  -16.14921 14.94311  1.000 65.24322  ? 341 VAL B C   1 
ATOM   388  O O   . VAL B 2 9   ? 12.25027  -15.29067 14.09761  1.000 62.75655  ? 341 VAL B O   1 
ATOM   389  C CB  . VAL B 2 9   ? 11.47961  -16.53459 17.21072  1.000 71.42393  ? 341 VAL B CB  1 
ATOM   390  C CG1 . VAL B 2 9   ? 11.46731  -15.02886 17.42370  1.000 64.17737  ? 341 VAL B CG1 1 
ATOM   391  C CG2 . VAL B 2 9   ? 10.31796  -17.19437 17.94455  1.000 66.33558  ? 341 VAL B CG2 1 
ATOM   392  N N   . PHE B 2 10  ? 13.77926  -16.50476 15.22652  1.000 62.71056  ? 342 PHE B N   1 
ATOM   393  C CA  . PHE B 2 10  ? 14.90941  -15.78764 14.64660  1.000 64.64942  ? 342 PHE B CA  1 
ATOM   394  C C   . PHE B 2 10  ? 15.12690  -16.14598 13.18236  1.000 63.21710  ? 342 PHE B C   1 
ATOM   395  O O   . PHE B 2 10  ? 15.38899  -15.26196 12.36036  1.000 63.95540  ? 342 PHE B O   1 
ATOM   396  C CB  . PHE B 2 10  ? 16.17888  -16.07119 15.44984  1.000 65.67888  ? 342 PHE B CB  1 
ATOM   397  C CG  . PHE B 2 10  ? 16.17987  -15.45439 16.81238  1.000 62.60406  ? 342 PHE B CG  1 
ATOM   398  C CD1 . PHE B 2 10  ? 15.62197  -16.12098 17.88963  1.000 67.44108  ? 342 PHE B CD1 1 
ATOM   399  C CD2 . PHE B 2 10  ? 16.73216  -14.20325 17.01643  1.000 59.37078  ? 342 PHE B CD2 1 
ATOM   400  C CE1 . PHE B 2 10  ? 15.61690  -15.55152 19.14427  1.000 62.17392  ? 342 PHE B CE1 1 
ATOM   401  C CE2 . PHE B 2 10  ? 16.73124  -13.62988 18.26747  1.000 63.27613  ? 342 PHE B CE2 1 
ATOM   402  C CZ  . PHE B 2 10  ? 16.17327  -14.30423 19.33407  1.000 59.45060  ? 342 PHE B CZ  1 
ATOM   403  N N   . ASN B 2 11  ? 15.03624  -17.42959 12.83630  1.000 64.97759  ? 343 ASN B N   1 
ATOM   404  C CA  . ASN B 2 11  ? 15.32070  -17.89160 11.48365  1.000 68.70551  ? 343 ASN B CA  1 
ATOM   405  C C   . ASN B 2 11  ? 14.05598  -18.04533 10.64595  1.000 66.15884  ? 343 ASN B C   1 
ATOM   406  O O   . ASN B 2 11  ? 14.02001  -18.86653 9.72367   1.000 71.03248  ? 343 ASN B O   1 
ATOM   407  C CB  . ASN B 2 11  ? 16.10336  -19.20623 11.52483  1.000 69.50637  ? 343 ASN B CB  1 
ATOM   408  C CG  . ASN B 2 11  ? 17.48952  -19.04239 12.12956  1.000 74.52555  ? 343 ASN B CG  1 
ATOM   409  O OD1 . ASN B 2 11  ? 18.12208  -17.99697 11.97996  1.000 80.48397  ? 343 ASN B OD1 1 
ATOM   410  N ND2 . ASN B 2 11  ? 17.96550  -20.07595 12.82043  1.000 73.43761  ? 343 ASN B ND2 1 
ATOM   411  N N   . ALA B 2 12  ? 13.02050  -17.26299 10.94232  1.000 64.83441  ? 344 ALA B N   1 
ATOM   412  C CA  . ALA B 2 12  ? 11.78426  -17.33233 10.17597  1.000 63.06668  ? 344 ALA B CA  1 
ATOM   413  C C   . ALA B 2 12  ? 11.96333  -16.70321 8.79779   1.000 57.00988  ? 344 ALA B C   1 
ATOM   414  O O   . ALA B 2 12  ? 12.75905  -15.77925 8.60649   1.000 58.72496  ? 344 ALA B O   1 
ATOM   415  C CB  . ALA B 2 12  ? 10.64857  -16.63568 10.92589  1.000 58.58229  ? 344 ALA B CB  1 
ATOM   416  N N   . THR B 2 13  ? 11.20692  -17.21782 7.82772   1.000 58.10952  ? 345 THR B N   1 
ATOM   417  C CA  . THR B 2 13  ? 11.31492  -16.71058 6.46340   1.000 61.18398  ? 345 THR B CA  1 
ATOM   418  C C   . THR B 2 13  ? 10.73863  -15.30453 6.35458   1.000 59.39154  ? 345 THR B C   1 
ATOM   419  O O   . THR B 2 13  ? 11.40550  -14.38269 5.86938   1.000 59.36939  ? 345 THR B O   1 
ATOM   420  C CB  . THR B 2 13  ? 10.60906  -17.65816 5.49122   1.000 65.36356  ? 345 THR B CB  1 
ATOM   421  O OG1 . THR B 2 13  ? 11.31046  -18.90707 5.44362   1.000 66.72652  ? 345 THR B OG1 1 
ATOM   422  C CG2 . THR B 2 13  ? 10.56177  -17.05455 4.09474   1.000 57.60819  ? 345 THR B CG2 1 
ATOM   423  N N   . ARG B 2 14  ? 9.50066   -15.12257 6.79998   1.000 57.44883  ? 346 ARG B N   1 
ATOM   424  C CA  . ARG B 2 14  ? 8.82589   -13.83459 6.74422   1.000 56.53732  ? 346 ARG B CA  1 
ATOM   425  C C   . ARG B 2 14  ? 8.88945   -13.14134 8.10082   1.000 57.75514  ? 346 ARG B C   1 
ATOM   426  O O   . ARG B 2 14  ? 8.80573   -13.79170 9.14687   1.000 57.24310  ? 346 ARG B O   1 
ATOM   427  C CB  . ARG B 2 14  ? 7.36789   -14.00905 6.31261   1.000 54.48485  ? 346 ARG B CB  1 
ATOM   428  C CG  . ARG B 2 14  ? 7.18568   -14.56004 4.89531   1.000 58.53752  ? 346 ARG B CG  1 
ATOM   429  C CD  . ARG B 2 14  ? 5.71476   -14.81889 4.59336   1.000 46.89170  ? 346 ARG B CD  1 
ATOM   430  N NE  . ARG B 2 14  ? 4.89736   -13.64414 4.86994   1.000 52.66011  ? 346 ARG B NE  1 
ATOM   431  C CZ  . ARG B 2 14  ? 3.57475   -13.65223 4.96015   1.000 56.71124  ? 346 ARG B CZ  1 
ATOM   432  N NH1 . ARG B 2 14  ? 2.87742   -14.76542 4.79704   1.000 52.61475  ? 346 ARG B NH1 1 
ATOM   433  N NH2 . ARG B 2 14  ? 2.93623   -12.51536 5.22633   1.000 55.67151  ? 346 ARG B NH2 1 
ATOM   434  N N   . PHE B 2 15  ? 9.04953   -11.81826 8.07370   1.000 54.23321  ? 347 PHE B N   1 
ATOM   435  C CA  . PHE B 2 15  ? 8.97776   -10.97114 9.25836   1.000 50.03989  ? 347 PHE B CA  1 
ATOM   436  C C   . PHE B 2 15  ? 7.90549   -9.91502  9.03967   1.000 52.24504  ? 347 PHE B C   1 
ATOM   437  O O   . PHE B 2 15  ? 7.69900   -9.45546  7.91013   1.000 42.04425  ? 347 PHE B O   1 
ATOM   438  C CB  . PHE B 2 15  ? 10.32512  -10.29189 9.55588   1.000 47.33208  ? 347 PHE B CB  1 
ATOM   439  C CG  . PHE B 2 15  ? 11.13917  -10.97978 10.61973  1.000 49.78459  ? 347 PHE B CG  1 
ATOM   440  C CD1 . PHE B 2 15  ? 11.34398  -12.34974 10.58489  1.000 56.11021  ? 347 PHE B CD1 1 
ATOM   441  C CD2 . PHE B 2 15  ? 11.71625  -10.24945 11.64744  1.000 45.20744  ? 347 PHE B CD2 1 
ATOM   442  C CE1 . PHE B 2 15  ? 12.10048  -12.98170 11.56860  1.000 52.77704  ? 347 PHE B CE1 1 
ATOM   443  C CE2 . PHE B 2 15  ? 12.47445  -10.87197 12.62894  1.000 49.08335  ? 347 PHE B CE2 1 
ATOM   444  C CZ  . PHE B 2 15  ? 12.66696  -12.24041 12.58862  1.000 47.99864  ? 347 PHE B CZ  1 
ATOM   445  N N   . ALA B 2 16  ? 7.23237   -9.52895  10.12110  1.000 40.20757  ? 348 ALA B N   1 
ATOM   446  C CA  . ALA B 2 16  ? 6.14355   -8.57005  10.02665  1.000 45.06997  ? 348 ALA B CA  1 
ATOM   447  C C   . ALA B 2 16  ? 6.67382   -7.15119  9.83971   1.000 39.70556  ? 348 ALA B C   1 
ATOM   448  O O   . ALA B 2 16  ? 7.83070   -6.84583  10.13732  1.000 40.23386  ? 348 ALA B O   1 
ATOM   449  C CB  . ALA B 2 16  ? 5.26406   -8.62990  11.27765  1.000 38.90528  ? 348 ALA B CB  1 
ATOM   450  N N   . SER B 2 17  ? 5.80657   -6.28098  9.32630   1.000 39.17221  ? 349 SER B N   1 
ATOM   451  C CA  . SER B 2 17  ? 6.08240   -4.85296  9.36770   1.000 37.61200  ? 349 SER B CA  1 
ATOM   452  C C   . SER B 2 17  ? 6.01892   -4.35582  10.80744  1.000 37.71529  ? 349 SER B C   1 
ATOM   453  O O   . SER B 2 17  ? 5.33216   -4.92821  11.65895  1.000 40.39840  ? 349 SER B O   1 
ATOM   454  C CB  . SER B 2 17  ? 5.08283   -4.07362  8.51230   1.000 36.17932  ? 349 SER B CB  1 
ATOM   455  O OG  . SER B 2 17  ? 5.29397   -4.28147  7.12564   1.000 45.75998  ? 349 SER B OG  1 
ATOM   456  N N   . VAL B 2 18  ? 6.73615   -3.26273  11.07451  1.000 37.50943  ? 350 VAL B N   1 
ATOM   457  C CA  . VAL B 2 18  ? 6.80581   -2.76682  12.44541  1.000 38.02266  ? 350 VAL B CA  1 
ATOM   458  C C   . VAL B 2 18  ? 5.44023   -2.28461  12.92976  1.000 40.22963  ? 350 VAL B C   1 
ATOM   459  O O   . VAL B 2 18  ? 5.08549   -2.49436  14.09538  1.000 39.89352  ? 350 VAL B O   1 
ATOM   460  C CB  . VAL B 2 18  ? 7.87983   -1.66973  12.57207  1.000 35.50763  ? 350 VAL B CB  1 
ATOM   461  C CG1 . VAL B 2 18  ? 7.53301   -0.45796  11.71657  1.000 35.71448  ? 350 VAL B CG1 1 
ATOM   462  C CG2 . VAL B 2 18  ? 8.06103   -1.27413  14.03648  1.000 36.43240  ? 350 VAL B CG2 1 
ATOM   463  N N   . TYR B 2 19  ? 4.64238   -1.65447  12.06028  1.000 34.70798  ? 351 TYR B N   1 
ATOM   464  C CA  . TYR B 2 19  ? 3.33807   -1.17622  12.50877  1.000 37.29248  ? 351 TYR B CA  1 
ATOM   465  C C   . TYR B 2 19  ? 2.43566   -2.33384  12.91208  1.000 43.48054  ? 351 TYR B C   1 
ATOM   466  O O   . TYR B 2 19  ? 1.55813   -2.16573  13.76772  1.000 41.08626  ? 351 TYR B O   1 
ATOM   467  C CB  . TYR B 2 19  ? 2.66392   -0.33276  11.42297  1.000 35.07435  ? 351 TYR B CB  1 
ATOM   468  C CG  . TYR B 2 19  ? 1.91820   -1.15047  10.39205  1.000 34.16534  ? 351 TYR B CG  1 
ATOM   469  C CD1 . TYR B 2 19  ? 2.58468   -1.70943  9.31325   1.000 38.06009  ? 351 TYR B CD1 1 
ATOM   470  C CD2 . TYR B 2 19  ? 0.54750   -1.36742  10.50203  1.000 38.98400  ? 351 TYR B CD2 1 
ATOM   471  C CE1 . TYR B 2 19  ? 1.91415   -2.46629  8.37140   1.000 39.89141  ? 351 TYR B CE1 1 
ATOM   472  C CE2 . TYR B 2 19  ? -0.13096  -2.12420  9.56856   1.000 40.88874  ? 351 TYR B CE2 1 
ATOM   473  C CZ  . TYR B 2 19  ? 0.55835   -2.66880  8.50257   1.000 42.63912  ? 351 TYR B CZ  1 
ATOM   474  O OH  . TYR B 2 19  ? -0.10747  -3.42308  7.56609   1.000 44.12598  ? 351 TYR B OH  1 
ATOM   475  N N   . ALA B 2 20  ? 2.63437   -3.50639  12.30838  1.000 38.53624  ? 352 ALA B N   1 
ATOM   476  C CA  . ALA B 2 20  ? 1.86689   -4.69813  12.64281  1.000 37.15864  ? 352 ALA B CA  1 
ATOM   477  C C   . ALA B 2 20  ? 2.77262   -5.74488  13.27975  1.000 38.42973  ? 352 ALA B C   1 
ATOM   478  O O   . ALA B 2 20  ? 2.66258   -6.93563  12.96622  1.000 37.99506  ? 352 ALA B O   1 
ATOM   479  C CB  . ALA B 2 20  ? 1.18773   -5.26666  11.39187  1.000 37.37577  ? 352 ALA B CB  1 
ATOM   480  N N   . TRP B 2 21  ? 3.66317   -5.30484  14.17146  1.000 34.30887  ? 353 TRP B N   1 
ATOM   481  C CA  . TRP B 2 21  ? 4.66113   -6.19140  14.75988  1.000 38.57997  ? 353 TRP B CA  1 
ATOM   482  C C   . TRP B 2 21  ? 4.02899   -7.47018  15.29692  1.000 42.55823  ? 353 TRP B C   1 
ATOM   483  O O   . TRP B 2 21  ? 2.91089   -7.46558  15.81955  1.000 39.43908  ? 353 TRP B O   1 
ATOM   484  C CB  . TRP B 2 21  ? 5.42831   -5.47384  15.87625  1.000 43.65786  ? 353 TRP B CB  1 
ATOM   485  C CG  . TRP B 2 21  ? 4.57439   -4.80956  16.93358  1.000 43.57404  ? 353 TRP B CG  1 
ATOM   486  C CD1 . TRP B 2 21  ? 4.03180   -3.55754  16.88079  1.000 42.40573  ? 353 TRP B CD1 1 
ATOM   487  C CD2 . TRP B 2 21  ? 4.19867   -5.35238  18.20919  1.000 44.01850  ? 353 TRP B CD2 1 
ATOM   488  N NE1 . TRP B 2 21  ? 3.33079   -3.29194  18.03421  1.000 41.47201  ? 353 TRP B NE1 1 
ATOM   489  C CE2 . TRP B 2 21  ? 3.41724   -4.37718  18.86530  1.000 46.53555  ? 353 TRP B CE2 1 
ATOM   490  C CE3 . TRP B 2 21  ? 4.44225   -6.56864  18.85676  1.000 46.04487  ? 353 TRP B CE3 1 
ATOM   491  C CZ2 . TRP B 2 21  ? 2.87767   -4.58063  20.13589  1.000 42.80937  ? 353 TRP B CZ2 1 
ATOM   492  C CZ3 . TRP B 2 21  ? 3.90312   -6.77029  20.11789  1.000 45.33535  ? 353 TRP B CZ3 1 
ATOM   493  C CH2 . TRP B 2 21  ? 3.13173   -5.77999  20.74346  1.000 44.92240  ? 353 TRP B CH2 1 
ATOM   494  N N   . ASN B 2 22  ? 4.75440   -8.57255  15.14059  1.000 40.34200  ? 354 ASN B N   1 
ATOM   495  C CA  . ASN B 2 22  ? 4.26911   -9.89610  15.49689  1.000 43.70656  ? 354 ASN B CA  1 
ATOM   496  C C   . ASN B 2 22  ? 4.67438   -10.23702 16.92444  1.000 47.46416  ? 354 ASN B C   1 
ATOM   497  O O   . ASN B 2 22  ? 5.76958   -9.88345  17.37013  1.000 45.92905  ? 354 ASN B O   1 
ATOM   498  C CB  . ASN B 2 22  ? 4.83203   -10.93582 14.52534  1.000 44.26731  ? 354 ASN B CB  1 
ATOM   499  C CG  . ASN B 2 22  ? 4.30914   -12.33189 14.79181  1.000 50.05548  ? 354 ASN B CG  1 
ATOM   500  O OD1 . ASN B 2 22  ? 3.26287   -12.72184 14.27201  1.000 46.35812  ? 354 ASN B OD1 1 
ATOM   501  N ND2 . ASN B 2 22  ? 5.03976   -13.09737 15.60071  1.000 47.68684  ? 354 ASN B ND2 1 
ATOM   502  N N   . ARG B 2 23  ? 3.78587   -10.92369 17.63980  1.000 44.91521  ? 355 ARG B N   1 
ATOM   503  C CA  . ARG B 2 23  ? 4.06981   -11.40380 18.98705  1.000 51.40113  ? 355 ARG B CA  1 
ATOM   504  C C   . ARG B 2 23  ? 3.85989   -12.90851 19.05707  1.000 48.87425  ? 355 ARG B C   1 
ATOM   505  O O   . ARG B 2 23  ? 2.77204   -13.40536 18.74681  1.000 54.16621  ? 355 ARG B O   1 
ATOM   506  C CB  . ARG B 2 23  ? 3.19536   -10.71371 20.03479  1.000 53.77178  ? 355 ARG B CB  1 
ATOM   507  C CG  . ARG B 2 23  ? 3.20168   -11.43339 21.37637  1.000 51.33854  ? 355 ARG B CG  1 
ATOM   508  C CD  . ARG B 2 23  ? 2.82219   -10.50660 22.50952  1.000 50.02334  ? 355 ARG B CD  1 
ATOM   509  N NE  . ARG B 2 23  ? 3.88181   -9.54734  22.78922  1.000 51.98865  ? 355 ARG B NE  1 
ATOM   510  C CZ  . ARG B 2 23  ? 3.83916   -8.64705  23.76071  1.000 50.72674  ? 355 ARG B CZ  1 
ATOM   511  N NH1 . ARG B 2 23  ? 2.79295   -8.54585  24.56411  1.000 53.21000  ? 355 ARG B NH1 1 
ATOM   512  N NH2 . ARG B 2 23  ? 4.87361   -7.83099  23.93270  1.000 44.91214  ? 355 ARG B NH2 1 
ATOM   513  N N   . LYS B 2 24  ? 4.89755   -13.62484 19.47968  1.000 51.25793  ? 356 LYS B N   1 
ATOM   514  C CA  . LYS B 2 24  ? 4.86383   -15.07720 19.62294  1.000 60.09447  ? 356 LYS B CA  1 
ATOM   515  C C   . LYS B 2 24  ? 5.04275   -15.41503 21.09849  1.000 62.86362  ? 356 LYS B C   1 
ATOM   516  O O   . LYS B 2 24  ? 6.11661   -15.18332 21.66607  1.000 61.92926  ? 356 LYS B O   1 
ATOM   517  C CB  . LYS B 2 24  ? 5.94876   -15.72919 18.76383  1.000 57.96047  ? 356 LYS B CB  1 
ATOM   518  C CG  . LYS B 2 24  ? 6.19244   -17.20659 19.03638  1.000 60.79221  ? 356 LYS B CG  1 
ATOM   519  C CD  . LYS B 2 24  ? 4.95814   -18.05472 18.77447  1.000 71.61616  ? 356 LYS B CD  1 
ATOM   520  C CE  . LYS B 2 24  ? 5.25809   -19.52817 19.01274  1.000 73.81157  ? 356 LYS B CE  1 
ATOM   521  N NZ  . LYS B 2 24  ? 4.03051   -20.36686 18.98973  1.000 74.84781  ? 356 LYS B NZ  1 
ATOM   522  N N   . ARG B 2 25  ? 3.99219   -15.94842 21.72228  1.000 64.15576  ? 357 ARG B N   1 
ATOM   523  C CA  . ARG B 2 25  ? 4.07185   -16.37006 23.11616  1.000 65.71527  ? 357 ARG B CA  1 
ATOM   524  C C   . ARG B 2 25  ? 4.77080   -17.72051 23.19578  1.000 67.89771  ? 357 ARG B C   1 
ATOM   525  O O   . ARG B 2 25  ? 4.34646   -18.68640 22.55306  1.000 72.09145  ? 357 ARG B O   1 
ATOM   526  C CB  . ARG B 2 25  ? 2.68386   -16.44949 23.74672  1.000 63.72765  ? 357 ARG B CB  1 
ATOM   527  C CG  . ARG B 2 25  ? 2.71485   -16.88690 25.20569  1.000 76.79035  ? 357 ARG B CG  1 
ATOM   528  C CD  . ARG B 2 25  ? 1.35284   -16.75451 25.86141  1.000 79.63014  ? 357 ARG B CD  1 
ATOM   529  N NE  . ARG B 2 25  ? 0.33030   -17.49578 25.13400  1.000 89.59993  ? 357 ARG B NE  1 
ATOM   530  C CZ  . ARG B 2 25  ? 0.05111   -18.77648 25.33234  1.000 89.32336  ? 357 ARG B CZ  1 
ATOM   531  N NH1 . ARG B 2 25  ? 0.69606   -19.49140 26.24110  1.000 80.57685  ? 357 ARG B NH1 1 
ATOM   532  N NH2 . ARG B 2 25  ? -0.89615  -19.35497 24.59809  1.000 91.06135  ? 357 ARG B NH2 1 
ATOM   533  N N   . ILE B 2 26  ? 5.83729   -17.78753 23.98405  1.000 66.78668  ? 358 ILE B N   1 
ATOM   534  C CA  . ILE B 2 26  ? 6.64289   -18.99237 24.13136  1.000 73.50592  ? 358 ILE B CA  1 
ATOM   535  C C   . ILE B 2 26  ? 6.48608   -19.49607 25.55858  1.000 79.26797  ? 358 ILE B C   1 
ATOM   536  O O   . ILE B 2 26  ? 6.79568   -18.77831 26.51819  1.000 72.29974  ? 358 ILE B O   1 
ATOM   537  C CB  . ILE B 2 26  ? 8.11589   -18.72741 23.79044  1.000 74.52192  ? 358 ILE B CB  1 
ATOM   538  C CG1 . ILE B 2 26  ? 8.25593   -18.44308 22.29237  1.000 75.85988  ? 358 ILE B CG1 1 
ATOM   539  C CG2 . ILE B 2 26  ? 8.97963   -19.90366 24.20989  1.000 75.01697  ? 358 ILE B CG2 1 
ATOM   540  C CD1 . ILE B 2 26  ? 9.66972   -18.17241 21.84922  1.000 74.15679  ? 358 ILE B CD1 1 
ATOM   541  N N   . SER B 2 27  ? 6.00445   -20.72857 25.69810  1.000 87.71183  ? 359 SER B N   1 
ATOM   542  C CA  . SER B 2 27  ? 5.78390   -21.31786 27.00925  1.000 88.47790  ? 359 SER B CA  1 
ATOM   543  C C   . SER B 2 27  ? 5.86082   -22.83334 26.89726  1.000 88.64540  ? 359 SER B C   1 
ATOM   544  O O   . SER B 2 27  ? 5.83028   -23.40007 25.80116  1.000 86.98217  ? 359 SER B O   1 
ATOM   545  C CB  . SER B 2 27  ? 4.43735   -20.88088 27.59781  1.000 88.36696  ? 359 SER B CB  1 
ATOM   546  O OG  . SER B 2 27  ? 3.37372   -21.18783 26.71397  1.000 83.31896  ? 359 SER B OG  1 
ATOM   547  N N   . ASN B 2 28  ? 5.96849   -23.48228 28.05935  1.000 91.00873  ? 360 ASN B N   1 
ATOM   548  C CA  . ASN B 2 28  ? 5.96930   -24.94103 28.17455  1.000 84.70927  ? 360 ASN B CA  1 
ATOM   549  C C   . ASN B 2 28  ? 7.14612   -25.55095 27.41371  1.000 79.53987  ? 360 ASN B C   1 
ATOM   550  O O   . ASN B 2 28  ? 6.98136   -26.39036 26.52573  1.000 87.67000  ? 360 ASN B O   1 
ATOM   551  C CB  . ASN B 2 28  ? 4.63762   -25.53020 27.69484  1.000 92.11085  ? 360 ASN B CB  1 
ATOM   552  C CG  . ASN B 2 28  ? 3.44789   -24.96874 28.44631  1.000 93.85092  ? 360 ASN B CG  1 
ATOM   553  O OD1 . ASN B 2 28  ? 3.52454   -24.71191 29.64736  1.000 92.04050  ? 360 ASN B OD1 1 
ATOM   554  N ND2 . ASN B 2 28  ? 2.33890   -24.77115 27.73974  1.000 90.43544  ? 360 ASN B ND2 1 
ATOM   555  N N   . CYS B 2 29  ? 8.34624   -25.11674 27.78668  1.000 72.72982  ? 361 CYS B N   1 
ATOM   556  C CA  . CYS B 2 29  ? 9.55343   -25.54922 27.09595  1.000 77.78492  ? 361 CYS B CA  1 
ATOM   557  C C   . CYS B 2 29  ? 10.76696  -25.10493 27.89989  1.000 80.88956  ? 361 CYS B C   1 
ATOM   558  O O   . CYS B 2 29  ? 10.66300  -24.31266 28.84074  1.000 74.17899  ? 361 CYS B O   1 
ATOM   559  C CB  . CYS B 2 29  ? 9.61197   -24.98921 25.67194  1.000 81.72739  ? 361 CYS B CB  1 
ATOM   560  S SG  . CYS B 2 29  ? 9.63088   -23.18107 25.58373  1.000 76.08028  ? 361 CYS B SG  1 
ATOM   561  N N   . VAL B 2 30  ? 11.92495  -25.62767 27.50517  1.000 85.02313  ? 362 VAL B N   1 
ATOM   562  C CA  . VAL B 2 30  ? 13.21108  -25.26997 28.08683  1.000 87.06638  ? 362 VAL B CA  1 
ATOM   563  C C   . VAL B 2 30  ? 14.08506  -24.69419 26.98181  1.000 87.68206  ? 362 VAL B C   1 
ATOM   564  O O   . VAL B 2 30  ? 14.11275  -25.22016 25.86356  1.000 89.03697  ? 362 VAL B O   1 
ATOM   565  C CB  . VAL B 2 30  ? 13.89250  -26.48615 28.74889  1.000 88.61539  ? 362 VAL B CB  1 
ATOM   566  C CG1 . VAL B 2 30  ? 15.16000  -26.06095 29.47122  1.000 85.07285  ? 362 VAL B CG1 1 
ATOM   567  C CG2 . VAL B 2 30  ? 12.93075  -27.18212 29.70288  1.000 87.94432  ? 362 VAL B CG2 1 
ATOM   568  N N   . ALA B 2 31  ? 14.79047  -23.60980 27.29079  1.000 81.05032  ? 363 ALA B N   1 
ATOM   569  C CA  . ALA B 2 31  ? 15.64621  -22.94343 26.32325  1.000 84.81454  ? 363 ALA B CA  1 
ATOM   570  C C   . ALA B 2 31  ? 17.01231  -22.68253 26.93759  1.000 87.84844  ? 363 ALA B C   1 
ATOM   571  O O   . ALA B 2 31  ? 17.15993  -22.58640 28.15802  1.000 90.69374  ? 363 ALA B O   1 
ATOM   572  C CB  . ALA B 2 31  ? 15.03448  -21.62369 25.84327  1.000 87.52934  ? 363 ALA B CB  1 
ATOM   573  N N   . ASP B 2 32  ? 18.01435  -22.56384 26.07205  1.000 84.46243  ? 364 ASP B N   1 
ATOM   574  C CA  . ASP B 2 32  ? 19.38240  -22.24698 26.47728  1.000 92.53526  ? 364 ASP B CA  1 
ATOM   575  C C   . ASP B 2 32  ? 19.65705  -20.80158 26.06844  1.000 95.40305  ? 364 ASP B C   1 
ATOM   576  O O   . ASP B 2 32  ? 20.11805  -20.52972 24.95792  1.000 95.10907  ? 364 ASP B O   1 
ATOM   577  C CB  . ASP B 2 32  ? 20.38807  -23.20916 25.85023  1.000 93.92888  ? 364 ASP B CB  1 
ATOM   578  C CG  . ASP B 2 32  ? 21.81318  -22.94076 26.30230  1.000 97.42585  ? 364 ASP B CG  1 
ATOM   579  O OD1 . ASP B 2 32  ? 22.00092  -22.19746 27.28854  1.000 97.87787  ? 364 ASP B OD1 1 
ATOM   580  O OD2 . ASP B 2 32  ? 22.74848  -23.46816 25.66515  1.000 99.19486  ? 364 ASP B OD2 1 
ATOM   581  N N   . TYR B 2 33  ? 19.37364  -19.87252 26.98531  1.000 94.99664  ? 365 TYR B N   1 
ATOM   582  C CA  . TYR B 2 33  ? 19.58843  -18.45606 26.71236  1.000 97.03401  ? 365 TYR B CA  1 
ATOM   583  C C   . TYR B 2 33  ? 21.06570  -18.09576 26.61102  1.000 97.57181  ? 365 TYR B C   1 
ATOM   584  O O   . TYR B 2 33  ? 21.39407  -17.03067 26.07700  1.000 98.22070  ? 365 TYR B O   1 
ATOM   585  C CB  . TYR B 2 33  ? 18.91928  -17.60600 27.79395  1.000 92.67956  ? 365 TYR B CB  1 
ATOM   586  C CG  . TYR B 2 33  ? 17.42457  -17.80025 27.87981  1.000 86.90755  ? 365 TYR B CG  1 
ATOM   587  C CD1 . TYR B 2 33  ? 16.56290  -17.05830 27.08364  1.000 81.99838  ? 365 TYR B CD1 1 
ATOM   588  C CD2 . TYR B 2 33  ? 16.87513  -18.72644 28.75688  1.000 88.78234  ? 365 TYR B CD2 1 
ATOM   589  C CE1 . TYR B 2 33  ? 15.19558  -17.23311 27.15740  1.000 83.68487  ? 365 TYR B CE1 1 
ATOM   590  C CE2 . TYR B 2 33  ? 15.51071  -18.90868 28.83872  1.000 89.47205  ? 365 TYR B CE2 1 
ATOM   591  C CZ  . TYR B 2 33  ? 14.67457  -18.15957 28.03737  1.000 88.15620  ? 365 TYR B CZ  1 
ATOM   592  O OH  . TYR B 2 33  ? 13.31289  -18.34044 28.11823  1.000 84.75101  ? 365 TYR B OH  1 
ATOM   593  N N   . SER B 2 34  ? 21.96252  -18.94978 27.11070  1.000 101.52090 ? 366 SER B N   1 
ATOM   594  C CA  . SER B 2 34  ? 23.38773  -18.65793 27.01441  1.000 106.84067 ? 366 SER B CA  1 
ATOM   595  C C   . SER B 2 34  ? 23.89775  -18.74666 25.58191  1.000 104.33768 ? 366 SER B C   1 
ATOM   596  O O   . SER B 2 34  ? 24.89951  -18.10339 25.25266  1.000 101.05166 ? 366 SER B O   1 
ATOM   597  C CB  . SER B 2 34  ? 24.18575  -19.60403 27.91318  1.000 100.15599 ? 366 SER B CB  1 
ATOM   598  N N   . VAL B 2 35  ? 23.22976  -19.52084 24.72008  1.000 100.44589 ? 367 VAL B N   1 
ATOM   599  C CA  . VAL B 2 35  ? 23.63971  -19.62062 23.32081  1.000 102.93397 ? 367 VAL B CA  1 
ATOM   600  C C   . VAL B 2 35  ? 23.10601  -18.48196 22.47066  1.000 109.58844 ? 367 VAL B C   1 
ATOM   601  O O   . VAL B 2 35  ? 23.40800  -18.42783 21.27098  1.000 108.05559 ? 367 VAL B O   1 
ATOM   602  C CB  . VAL B 2 35  ? 23.19121  -20.96921 22.72241  1.000 91.55361  ? 367 VAL B CB  1 
ATOM   603  N N   . LEU B 2 36  ? 22.32818  -17.56861 23.05297  1.000 110.95309 ? 368 LEU B N   1 
ATOM   604  C CA  . LEU B 2 36  ? 21.68937  -16.49492 22.30306  1.000 109.47472 ? 368 LEU B CA  1 
ATOM   605  C C   . LEU B 2 36  ? 22.65133  -15.38315 21.91045  1.000 111.29950 ? 368 LEU B C   1 
ATOM   606  O O   . LEU B 2 36  ? 22.24566  -14.46878 21.18032  1.000 110.88257 ? 368 LEU B O   1 
ATOM   607  C CB  . LEU B 2 36  ? 20.52525  -15.90732 23.10672  1.000 97.92822  ? 368 LEU B CB  1 
ATOM   608  N N   . TYR B 2 37  ? 23.90029  -15.42800 22.38445  1.000 107.90506 ? 369 TYR B N   1 
ATOM   609  C CA  . TYR B 2 37  ? 24.92644  -14.55318 21.83396  1.000 102.57055 ? 369 TYR B CA  1 
ATOM   610  C C   . TYR B 2 37  ? 25.19705  -14.86847 20.37131  1.000 111.05393 ? 369 TYR B C   1 
ATOM   611  O O   . TYR B 2 37  ? 25.77054  -14.03485 19.66013  1.000 115.16243 ? 369 TYR B O   1 
ATOM   612  C CB  . TYR B 2 37  ? 26.21867  -14.67713 22.64055  1.000 102.16504 ? 369 TYR B CB  1 
ATOM   613  N N   . ASN B 2 38  ? 24.80005  -16.05468 19.91459  1.000 110.07225 ? 370 ASN B N   1 
ATOM   614  C CA  . ASN B 2 38  ? 24.85786  -16.45618 18.51469  1.000 109.37500 ? 370 ASN B CA  1 
ATOM   615  C C   . ASN B 2 38  ? 23.55061  -17.11528 18.09979  1.000 112.90271 ? 370 ASN B C   1 
ATOM   616  O O   . ASN B 2 38  ? 23.52826  -18.23233 17.58084  1.000 113.10795 ? 370 ASN B O   1 
ATOM   617  C CB  . ASN B 2 38  ? 26.02609  -17.40105 18.26247  1.000 98.25732  ? 370 ASN B CB  1 
ATOM   618  N N   . PHE B 2 39  ? 22.43658  -16.42826 18.33781  1.000 112.28331 ? 371 PHE B N   1 
ATOM   619  C CA  . PHE B 2 39  ? 21.12238  -16.90757 17.91612  1.000 106.61748 ? 371 PHE B CA  1 
ATOM   620  C C   . PHE B 2 39  ? 20.49201  -15.95932 16.89610  1.000 97.89347  ? 371 PHE B C   1 
ATOM   621  O O   . PHE B 2 39  ? 20.58283  -14.73726 17.02888  1.000 91.80562  ? 371 PHE B O   1 
ATOM   622  C CB  . PHE B 2 39  ? 20.19405  -17.06706 19.12283  1.000 91.79511  ? 371 PHE B CB  1 
ATOM   623  N N   . PHE B 2 42  ? 25.59964  -13.47832 12.48122  1.000 76.98015  ? 374 PHE B N   1 
ATOM   624  C CA  . PHE B 2 42  ? 25.57477  -12.03202 12.67488  1.000 75.29984  ? 374 PHE B CA  1 
ATOM   625  C C   . PHE B 2 42  ? 24.39760  -11.62582 13.55486  1.000 80.97457  ? 374 PHE B C   1 
ATOM   626  O O   . PHE B 2 42  ? 23.27492  -12.09162 13.35199  1.000 79.56868  ? 374 PHE B O   1 
ATOM   627  C CB  . PHE B 2 42  ? 25.50150  -11.30575 11.32891  1.000 68.11515  ? 374 PHE B CB  1 
ATOM   628  N N   . SER B 2 43  ? 24.66340  -10.76039 14.53040  1.000 73.58002  ? 375 SER B N   1 
ATOM   629  C CA  . SER B 2 43  ? 23.63875  -10.28417 15.45135  1.000 68.21764  ? 375 SER B CA  1 
ATOM   630  C C   . SER B 2 43  ? 24.16440  -9.05401  16.17600  1.000 71.33074  ? 375 SER B C   1 
ATOM   631  O O   . SER B 2 43  ? 25.33087  -8.67352  16.04824  1.000 74.98876  ? 375 SER B O   1 
ATOM   632  C CB  . SER B 2 43  ? 23.22744  -11.35704 16.46677  1.000 64.79422  ? 375 SER B CB  1 
ATOM   633  O OG  . SER B 2 43  ? 22.22016  -12.20166 15.94361  1.000 76.13431  ? 375 SER B OG  1 
ATOM   634  N N   . ALA B 2 44  ? 23.26799  -8.43241  16.93196  1.000 73.65112  ? 376 ALA B N   1 
ATOM   635  C CA  . ALA B 2 44  ? 23.59643  -7.35791  17.85904  1.000 62.21824  ? 376 ALA B CA  1 
ATOM   636  C C   . ALA B 2 44  ? 22.52481  -7.40140  18.93171  1.000 61.99125  ? 376 ALA B C   1 
ATOM   637  O O   . ALA B 2 44  ? 21.33563  -7.29843  18.61454  1.000 64.74295  ? 376 ALA B O   1 
ATOM   638  C CB  . ALA B 2 44  ? 23.62777  -5.99526  17.16593  1.000 58.53408  ? 376 ALA B CB  1 
ATOM   639  N N   . PHE B 2 45  ? 22.92987  -7.59027  20.18385  1.000 63.53941  ? 377 PHE B N   1 
ATOM   640  C CA  . PHE B 2 45  ? 21.96538  -7.82533  21.24470  1.000 62.78327  ? 377 PHE B CA  1 
ATOM   641  C C   . PHE B 2 45  ? 22.36256  -7.04922  22.48865  1.000 63.27365  ? 377 PHE B C   1 
ATOM   642  O O   . PHE B 2 45  ? 23.54546  -6.81749  22.74669  1.000 68.66113  ? 377 PHE B O   1 
ATOM   643  C CB  . PHE B 2 45  ? 21.84157  -9.32266  21.56828  1.000 62.10326  ? 377 PHE B CB  1 
ATOM   644  C CG  . PHE B 2 45  ? 22.72212  -9.77800  22.69564  1.000 69.36661  ? 377 PHE B CG  1 
ATOM   645  C CD1 . PHE B 2 45  ? 24.08462  -9.94408  22.51019  1.000 76.01464  ? 377 PHE B CD1 1 
ATOM   646  C CD2 . PHE B 2 45  ? 22.18188  -10.05222 23.94054  1.000 73.17478  ? 377 PHE B CD2 1 
ATOM   647  C CE1 . PHE B 2 45  ? 24.89390  -10.36768 23.55116  1.000 80.57173  ? 377 PHE B CE1 1 
ATOM   648  C CE2 . PHE B 2 45  ? 22.98375  -10.47473 24.98357  1.000 81.61191  ? 377 PHE B CE2 1 
ATOM   649  C CZ  . PHE B 2 45  ? 24.34160  -10.63362 24.78883  1.000 81.06077  ? 377 PHE B CZ  1 
ATOM   650  N N   . LYS B 2 46  ? 21.35278  -6.63823  23.24919  1.000 61.16167  ? 378 LYS B N   1 
ATOM   651  C CA  . LYS B 2 46  ? 21.57083  -6.00249  24.54118  1.000 56.90627  ? 378 LYS B CA  1 
ATOM   652  C C   . LYS B 2 46  ? 20.42137  -6.39095  25.44944  1.000 62.69655  ? 378 LYS B C   1 
ATOM   653  O O   . LYS B 2 46  ? 19.25635  -6.20449  25.08855  1.000 59.23208  ? 378 LYS B O   1 
ATOM   654  C CB  . LYS B 2 46  ? 21.66421  -4.48172  24.41822  1.000 53.14813  ? 378 LYS B CB  1 
ATOM   655  C CG  . LYS B 2 46  ? 21.78838  -3.77450  25.76262  1.000 58.20635  ? 378 LYS B CG  1 
ATOM   656  C CD  . LYS B 2 46  ? 21.96198  -2.27639  25.59633  1.000 66.25172  ? 378 LYS B CD  1 
ATOM   657  C CE  . LYS B 2 46  ? 22.23400  -1.61068  26.93924  1.000 71.11977  ? 378 LYS B CE  1 
ATOM   658  N NZ  . LYS B 2 46  ? 22.31014  -0.12473  26.82286  1.000 84.68417  ? 378 LYS B NZ  1 
ATOM   659  N N   . CYS B 2 47  ? 20.74748  -6.93346  26.61323  1.000 62.69990  ? 379 CYS B N   1 
ATOM   660  C CA  . CYS B 2 47  ? 19.75333  -7.24406  27.62490  1.000 57.85261  ? 379 CYS B CA  1 
ATOM   661  C C   . CYS B 2 47  ? 19.74796  -6.12735  28.65728  1.000 55.82589  ? 379 CYS B C   1 
ATOM   662  O O   . CYS B 2 47  ? 20.80948  -5.69490  29.11885  1.000 54.73582  ? 379 CYS B O   1 
ATOM   663  C CB  . CYS B 2 47  ? 20.04017  -8.59567  28.27433  1.000 60.47362  ? 379 CYS B CB  1 
ATOM   664  S SG  . CYS B 2 47  ? 19.91434  -9.98553  27.11965  1.000 73.64357  ? 379 CYS B SG  1 
ATOM   665  N N   . TYR B 2 48  ? 18.55745  -5.63996  28.98634  1.000 52.16443  ? 380 TYR B N   1 
ATOM   666  C CA  . TYR B 2 48  ? 18.40617  -4.53328  29.91753  1.000 54.03807  ? 380 TYR B CA  1 
ATOM   667  C C   . TYR B 2 48  ? 18.11731  -4.99773  31.33688  1.000 63.27517  ? 380 TYR B C   1 
ATOM   668  O O   . TYR B 2 48  ? 18.09335  -4.16813  32.25254  1.000 61.91413  ? 380 TYR B O   1 
ATOM   669  C CB  . TYR B 2 48  ? 17.30548  -3.58789  29.42117  1.000 53.72303  ? 380 TYR B CB  1 
ATOM   670  C CG  . TYR B 2 48  ? 17.68045  -2.90035  28.12502  1.000 54.31746  ? 380 TYR B CG  1 
ATOM   671  C CD1 . TYR B 2 48  ? 17.41940  -3.49660  26.89645  1.000 52.72524  ? 380 TYR B CD1 1 
ATOM   672  C CD2 . TYR B 2 48  ? 18.32579  -1.67015  28.13284  1.000 52.98390  ? 380 TYR B CD2 1 
ATOM   673  C CE1 . TYR B 2 48  ? 17.77641  -2.87819  25.71097  1.000 51.85481  ? 380 TYR B CE1 1 
ATOM   674  C CE2 . TYR B 2 48  ? 18.68617  -1.04523  26.95528  1.000 56.13849  ? 380 TYR B CE2 1 
ATOM   675  C CZ  . TYR B 2 48  ? 18.40914  -1.65353  25.74822  1.000 54.09685  ? 380 TYR B CZ  1 
ATOM   676  O OH  . TYR B 2 48  ? 18.76560  -1.03292  24.57489  1.000 58.41980  ? 380 TYR B OH  1 
ATOM   677  N N   . GLY B 2 49  ? 17.89749  -6.29582  31.53552  1.000 67.53856  ? 381 GLY B N   1 
ATOM   678  C CA  . GLY B 2 49  ? 17.82067  -6.87019  32.86444  1.000 75.16021  ? 381 GLY B CA  1 
ATOM   679  C C   . GLY B 2 49  ? 19.09800  -7.60385  33.22041  1.000 76.06734  ? 381 GLY B C   1 
ATOM   680  O O   . GLY B 2 49  ? 20.19286  -7.05056  33.08019  1.000 74.34947  ? 381 GLY B O   1 
ATOM   681  N N   . VAL B 2 50  ? 18.97850  -8.85276  33.66831  1.000 81.02184  ? 382 VAL B N   1 
ATOM   682  C CA  . VAL B 2 50  ? 20.14858  -9.65516  34.01031  1.000 90.74702  ? 382 VAL B CA  1 
ATOM   683  C C   . VAL B 2 50  ? 20.78340  -10.18935 32.73244  1.000 91.05464  ? 382 VAL B C   1 
ATOM   684  O O   . VAL B 2 50  ? 20.18945  -10.11195 31.65113  1.000 89.16659  ? 382 VAL B O   1 
ATOM   685  C CB  . VAL B 2 50  ? 19.78556  -10.80236 34.97308  1.000 93.64593  ? 382 VAL B CB  1 
ATOM   686  C CG1 . VAL B 2 50  ? 19.36619  -10.24777 36.32880  1.000 83.63364  ? 382 VAL B CG1 1 
ATOM   687  C CG2 . VAL B 2 50  ? 18.68466  -11.67200 34.38031  1.000 89.40407  ? 382 VAL B CG2 1 
ATOM   688  N N   . SER B 2 51  ? 21.99469  -10.73144 32.85030  1.000 98.67542  ? 383 SER B N   1 
ATOM   689  C CA  . SER B 2 51  ? 22.71087  -11.25663 31.70052  1.000 93.03757  ? 383 SER B CA  1 
ATOM   690  C C   . SER B 2 51  ? 22.00422  -12.49189 31.14415  1.000 95.17282  ? 383 SER B C   1 
ATOM   691  O O   . SER B 2 51  ? 21.21874  -13.13841 31.84211  1.000 93.83096  ? 383 SER B O   1 
ATOM   692  C CB  . SER B 2 51  ? 24.14655  -11.60649 32.08828  1.000 93.63746  ? 383 SER B CB  1 
ATOM   693  O OG  . SER B 2 51  ? 24.83966  -10.47247 32.57662  1.000 104.21621 ? 383 SER B OG  1 
ATOM   694  N N   . PRO B 2 52  ? 22.26246  -12.83701 29.87893  1.000 93.65738  ? 384 PRO B N   1 
ATOM   695  C CA  . PRO B 2 52  ? 21.70181  -14.08656 29.33814  1.000 95.17285  ? 384 PRO B CA  1 
ATOM   696  C C   . PRO B 2 52  ? 22.17554  -15.32656 30.07314  1.000 98.90090  ? 384 PRO B C   1 
ATOM   697  O O   . PRO B 2 52  ? 21.48899  -16.35516 30.02737  1.000 98.03263  ? 384 PRO B O   1 
ATOM   698  C CB  . PRO B 2 52  ? 22.17256  -14.08352 27.87606  1.000 94.23347  ? 384 PRO B CB  1 
ATOM   699  C CG  . PRO B 2 52  ? 23.32862  -13.13200 27.83962  1.000 86.68241  ? 384 PRO B CG  1 
ATOM   700  C CD  . PRO B 2 52  ? 23.01395  -12.08469 28.85911  1.000 88.42420  ? 384 PRO B CD  1 
ATOM   701  N N   . THR B 2 53  ? 23.32695  -15.26383 30.74610  1.000 101.09345 ? 385 THR B N   1 
ATOM   702  C CA  . THR B 2 53  ? 23.77182  -16.38401 31.56861  1.000 100.93076 ? 385 THR B CA  1 
ATOM   703  C C   . THR B 2 53  ? 22.83877  -16.59035 32.75599  1.000 96.93214  ? 385 THR B C   1 
ATOM   704  O O   . THR B 2 53  ? 22.39969  -17.71457 33.02691  1.000 94.64389  ? 385 THR B O   1 
ATOM   705  C CB  . THR B 2 53  ? 25.20742  -16.14749 32.04137  1.000 101.94890 ? 385 THR B CB  1 
ATOM   706  O OG1 . THR B 2 53  ? 26.07389  -16.04507 30.90390  1.000 101.25259 ? 385 THR B OG1 1 
ATOM   707  C CG2 . THR B 2 53  ? 25.67557  -17.29065 32.92836  1.000 99.50399  ? 385 THR B CG2 1 
ATOM   708  N N   . LYS B 2 54  ? 22.51562  -15.50858 33.47103  1.000 96.07562  ? 386 LYS B N   1 
ATOM   709  C CA  . LYS B 2 54  ? 21.58304  -15.59672 34.58879  1.000 91.95758  ? 386 LYS B CA  1 
ATOM   710  C C   . LYS B 2 54  ? 20.17792  -15.97195 34.14091  1.000 95.87992  ? 386 LYS B C   1 
ATOM   711  O O   . LYS B 2 54  ? 19.39956  -16.48390 34.95226  1.000 93.67501  ? 386 LYS B O   1 
ATOM   712  C CB  . LYS B 2 54  ? 21.54490  -14.27217 35.35195  1.000 89.96404  ? 386 LYS B CB  1 
ATOM   713  C CG  . LYS B 2 54  ? 22.88900  -13.84262 35.91181  1.000 95.01885  ? 386 LYS B CG  1 
ATOM   714  C CD  . LYS B 2 54  ? 22.76482  -12.57163 36.73270  1.000 94.82836  ? 386 LYS B CD  1 
ATOM   715  C CE  . LYS B 2 54  ? 24.09921  -12.18512 37.34780  1.000 89.75426  ? 386 LYS B CE  1 
ATOM   716  N NZ  . LYS B 2 54  ? 23.99521  -10.94739 38.16780  1.000 90.76144  ? 386 LYS B NZ  1 
ATOM   717  N N   . LEU B 2 55  ? 19.83558  -15.72478 32.87355  1.000 97.36955  ? 387 LEU B N   1 
ATOM   718  C CA  . LEU B 2 55  ? 18.53213  -16.13695 32.36535  1.000 94.89469  ? 387 LEU B CA  1 
ATOM   719  C C   . LEU B 2 55  ? 18.39929  -17.65285 32.33205  1.000 94.10846  ? 387 LEU B C   1 
ATOM   720  O O   . LEU B 2 55  ? 17.28894  -18.17856 32.47200  1.000 93.81888  ? 387 LEU B O   1 
ATOM   721  C CB  . LEU B 2 55  ? 18.30109  -15.55091 30.97189  1.000 97.88819  ? 387 LEU B CB  1 
ATOM   722  C CG  . LEU B 2 55  ? 18.11653  -14.03402 30.88488  1.000 90.58338  ? 387 LEU B CG  1 
ATOM   723  C CD1 . LEU B 2 55  ? 18.05575  -13.58921 29.43440  1.000 92.20868  ? 387 LEU B CD1 1 
ATOM   724  C CD2 . LEU B 2 55  ? 16.86040  -13.60357 31.62823  1.000 85.05736  ? 387 LEU B CD2 1 
ATOM   725  N N   . ASN B 2 56  ? 19.51254  -18.36859 32.14792  1.000 97.45757  ? 388 ASN B N   1 
ATOM   726  C CA  . ASN B 2 56  ? 19.48127  -19.82460 32.20848  1.000 98.18519  ? 388 ASN B CA  1 
ATOM   727  C C   . ASN B 2 56  ? 19.20962  -20.33973 33.61470  1.000 99.85510  ? 388 ASN B C   1 
ATOM   728  O O   . ASN B 2 56  ? 18.76891  -21.48410 33.76712  1.000 101.00389 ? 388 ASN B O   1 
ATOM   729  C CB  . ASN B 2 56  ? 20.79539  -20.40797 31.68985  1.000 98.26752  ? 388 ASN B CB  1 
ATOM   730  C CG  . ASN B 2 56  ? 20.71063  -20.82803 30.23878  1.000 97.27439  ? 388 ASN B CG  1 
ATOM   731  O OD1 . ASN B 2 56  ? 19.62182  -20.94998 29.67869  1.000 94.08169  ? 388 ASN B OD1 1 
ATOM   732  N ND2 . ASN B 2 56  ? 21.86143  -21.06622 29.62481  1.000 96.61619  ? 388 ASN B ND2 1 
ATOM   733  N N   . ASP B 2 57  ? 19.46193  -19.52741 34.64030  1.000 100.38559 ? 389 ASP B N   1 
ATOM   734  C CA  . ASP B 2 57  ? 19.17490  -19.91983 36.01223  1.000 98.21561  ? 389 ASP B CA  1 
ATOM   735  C C   . ASP B 2 57  ? 17.74555  -19.61040 36.43010  1.000 99.27678  ? 389 ASP B C   1 
ATOM   736  O O   . ASP B 2 57  ? 17.26589  -20.18208 37.41580  1.000 102.38158 ? 389 ASP B O   1 
ATOM   737  C CB  . ASP B 2 57  ? 20.13897  -19.22171 36.97760  1.000 94.37157  ? 389 ASP B CB  1 
ATOM   738  C CG  . ASP B 2 57  ? 21.58713  -19.35771 36.55595  1.000 95.54826  ? 389 ASP B CG  1 
ATOM   739  O OD1 . ASP B 2 57  ? 21.91969  -20.34726 35.87082  1.000 99.34405  ? 389 ASP B OD1 1 
ATOM   740  O OD2 . ASP B 2 57  ? 22.39375  -18.47288 36.91002  1.000 94.74209  ? 389 ASP B OD2 1 
ATOM   741  N N   . LEU B 2 58  ? 17.05729  -18.73376 35.70779  1.000 97.37425  ? 390 LEU B N   1 
ATOM   742  C CA  . LEU B 2 58  ? 15.73503  -18.26889 36.09425  1.000 96.66529  ? 390 LEU B CA  1 
ATOM   743  C C   . LEU B 2 58  ? 14.64686  -18.99192 35.31055  1.000 89.56481  ? 390 LEU B C   1 
ATOM   744  O O   . LEU B 2 58  ? 14.88715  -19.58111 34.25358  1.000 92.31209  ? 390 LEU B O   1 
ATOM   745  C CB  . LEU B 2 58  ? 15.60923  -16.75790 35.88020  1.000 91.29154  ? 390 LEU B CB  1 
ATOM   746  C CG  . LEU B 2 58  ? 16.66458  -15.88856 36.56530  1.000 93.62052  ? 390 LEU B CG  1 
ATOM   747  C CD1 . LEU B 2 58  ? 16.45193  -14.42068 36.23109  1.000 90.86196  ? 390 LEU B CD1 1 
ATOM   748  C CD2 . LEU B 2 58  ? 16.65400  -16.10963 38.06970  1.000 91.21041  ? 390 LEU B CD2 1 
ATOM   749  N N   . CYS B 2 59  ? 13.43491  -18.93711 35.85621  1.000 86.45150  ? 391 CYS B N   1 
ATOM   750  C CA  . CYS B 2 59  ? 12.24360  -19.46313 35.21070  1.000 86.34580  ? 391 CYS B CA  1 
ATOM   751  C C   . CYS B 2 59  ? 11.18048  -18.37625 35.17465  1.000 85.11238  ? 391 CYS B C   1 
ATOM   752  O O   . CYS B 2 59  ? 11.12887  -17.50868 36.05163  1.000 86.90025  ? 391 CYS B O   1 
ATOM   753  C CB  . CYS B 2 59  ? 11.69633  -20.69418 35.94128  1.000 92.84240  ? 391 CYS B CB  1 
ATOM   754  S SG  . CYS B 2 59  ? 12.79253  -22.12876 35.98191  1.000 103.78446 ? 391 CYS B SG  1 
ATOM   755  N N   . PHE B 2 60  ? 10.32742  -18.43313 34.15392  1.000 82.81321  ? 392 PHE B N   1 
ATOM   756  C CA  . PHE B 2 60  ? 9.29099   -17.43013 33.96298  1.000 81.20555  ? 392 PHE B CA  1 
ATOM   757  C C   . PHE B 2 60  ? 8.00126   -18.10579 33.52375  1.000 77.82265  ? 392 PHE B C   1 
ATOM   758  O O   . PHE B 2 60  ? 8.00698   -19.21288 32.98018  1.000 81.92915  ? 392 PHE B O   1 
ATOM   759  C CB  . PHE B 2 60  ? 9.70806   -16.37176 32.93290  1.000 75.08594  ? 392 PHE B CB  1 
ATOM   760  C CG  . PHE B 2 60  ? 10.93140  -15.59386 33.32340  1.000 69.34726  ? 392 PHE B CG  1 
ATOM   761  C CD1 . PHE B 2 60  ? 10.82423  -14.45628 34.10336  1.000 67.81820  ? 392 PHE B CD1 1 
ATOM   762  C CD2 . PHE B 2 60  ? 12.18876  -15.99613 32.90404  1.000 68.93707  ? 392 PHE B CD2 1 
ATOM   763  C CE1 . PHE B 2 60  ? 11.94945  -13.73586 34.46033  1.000 68.11190  ? 392 PHE B CE1 1 
ATOM   764  C CE2 . PHE B 2 60  ? 13.31778  -15.27868 33.25821  1.000 71.59209  ? 392 PHE B CE2 1 
ATOM   765  C CZ  . PHE B 2 60  ? 13.19722  -14.14824 34.03660  1.000 62.38365  ? 392 PHE B CZ  1 
ATOM   766  N N   . THR B 2 61  ? 6.88695   -17.41351 33.76748  1.000 76.19624  ? 393 THR B N   1 
ATOM   767  C CA  . THR B 2 61  ? 5.58217   -17.93721 33.37715  1.000 77.24067  ? 393 THR B CA  1 
ATOM   768  C C   . THR B 2 61  ? 5.44689   -17.99454 31.86133  1.000 83.84570  ? 393 THR B C   1 
ATOM   769  O O   . THR B 2 61  ? 5.11041   -19.04130 31.29601  1.000 85.88666  ? 393 THR B O   1 
ATOM   770  C CB  . THR B 2 61  ? 4.47200   -17.07609 33.97931  1.000 83.54156  ? 393 THR B CB  1 
ATOM   771  O OG1 . THR B 2 61  ? 4.71251   -16.89111 35.37952  1.000 85.74333  ? 393 THR B OG1 1 
ATOM   772  C CG2 . THR B 2 61  ? 3.11745   -17.74121 33.78800  1.000 82.70983  ? 393 THR B CG2 1 
ATOM   773  N N   . ASN B 2 62  ? 5.69676   -16.87280 31.18878  1.000 84.83611  ? 394 ASN B N   1 
ATOM   774  C CA  . ASN B 2 62  ? 5.65734   -16.79869 29.73686  1.000 77.66508  ? 394 ASN B CA  1 
ATOM   775  C C   . ASN B 2 62  ? 6.78377   -15.90274 29.24812  1.000 74.51618  ? 394 ASN B C   1 
ATOM   776  O O   . ASN B 2 62  ? 7.18713   -14.95557 29.92866  1.000 74.24265  ? 394 ASN B O   1 
ATOM   777  C CB  . ASN B 2 62  ? 4.31836   -16.25531 29.22173  1.000 77.85373  ? 394 ASN B CB  1 
ATOM   778  C CG  . ASN B 2 62  ? 3.16951   -17.20380 29.46940  1.000 79.99052  ? 394 ASN B CG  1 
ATOM   779  O OD1 . ASN B 2 62  ? 2.90899   -18.10479 28.67095  1.000 80.14238  ? 394 ASN B OD1 1 
ATOM   780  N ND2 . ASN B 2 62  ? 2.46545   -17.00074 30.57564  1.000 84.18953  ? 394 ASN B ND2 1 
ATOM   781  N N   . VAL B 2 63  ? 7.28788   -16.21431 28.05902  1.000 69.09124  ? 395 VAL B N   1 
ATOM   782  C CA  . VAL B 2 63  ? 8.28242   -15.39626 27.37680  1.000 68.05209  ? 395 VAL B CA  1 
ATOM   783  C C   . VAL B 2 63  ? 7.68206   -14.95379 26.05109  1.000 64.04484  ? 395 VAL B C   1 
ATOM   784  O O   . VAL B 2 63  ? 7.25097   -15.79219 25.24952  1.000 68.02145  ? 395 VAL B O   1 
ATOM   785  C CB  . VAL B 2 63  ? 9.59882   -16.15670 27.15957  1.000 71.14998  ? 395 VAL B CB  1 
ATOM   786  C CG1 . VAL B 2 63  ? 10.52220  -15.36479 26.25025  1.000 67.72461  ? 395 VAL B CG1 1 
ATOM   787  C CG2 . VAL B 2 63  ? 10.27175  -16.43387 28.49424  1.000 72.45464  ? 395 VAL B CG2 1 
ATOM   788  N N   . TYR B 2 64  ? 7.64260   -13.64391 25.82487  1.000 67.58869  ? 396 TYR B N   1 
ATOM   789  C CA  . TYR B 2 64  ? 7.09340   -13.07832 24.59961  1.000 62.49376  ? 396 TYR B CA  1 
ATOM   790  C C   . TYR B 2 64  ? 8.22382   -12.66512 23.66930  1.000 56.71986  ? 396 TYR B C   1 
ATOM   791  O O   . TYR B 2 64  ? 9.18916   -12.02484 24.09987  1.000 54.14261  ? 396 TYR B O   1 
ATOM   792  C CB  . TYR B 2 64  ? 6.19289   -11.88198 24.90339  1.000 58.12989  ? 396 TYR B CB  1 
ATOM   793  C CG  . TYR B 2 64  ? 5.00784   -12.24626 25.75545  1.000 60.95063  ? 396 TYR B CG  1 
ATOM   794  C CD1 . TYR B 2 64  ? 3.84011   -12.73049 25.18303  1.000 64.24052  ? 396 TYR B CD1 1 
ATOM   795  C CD2 . TYR B 2 64  ? 5.06262   -12.12224 27.13780  1.000 69.47763  ? 396 TYR B CD2 1 
ATOM   796  C CE1 . TYR B 2 64  ? 2.75339   -13.07306 25.96493  1.000 77.07180  ? 396 TYR B CE1 1 
ATOM   797  C CE2 . TYR B 2 64  ? 3.98504   -12.46012 27.92723  1.000 72.23070  ? 396 TYR B CE2 1 
ATOM   798  C CZ  . TYR B 2 64  ? 2.83341   -12.93581 27.33783  1.000 77.20181  ? 396 TYR B CZ  1 
ATOM   799  O OH  . TYR B 2 64  ? 1.75863   -13.27345 28.12655  1.000 81.66734  ? 396 TYR B OH  1 
ATOM   800  N N   . ALA B 2 65  ? 8.10180   -13.04257 22.39930  1.000 56.53058  ? 397 ALA B N   1 
ATOM   801  C CA  . ALA B 2 65  ? 9.05650   -12.67444 21.36018  1.000 52.60346  ? 397 ALA B CA  1 
ATOM   802  C C   . ALA B 2 65  ? 8.33859   -11.78748 20.35141  1.000 52.98963  ? 397 ALA B C   1 
ATOM   803  O O   . ALA B 2 65  ? 7.41541   -12.24027 19.66418  1.000 53.15775  ? 397 ALA B O   1 
ATOM   804  C CB  . ALA B 2 65  ? 9.64365   -13.91402 20.68695  1.000 54.64411  ? 397 ALA B CB  1 
ATOM   805  N N   . ASP B 2 66  ? 8.75296   -10.52674 20.27486  1.000 48.21296  ? 398 ASP B N   1 
ATOM   806  C CA  . ASP B 2 66  ? 8.22250   -9.57725  19.30636  1.000 50.39268  ? 398 ASP B CA  1 
ATOM   807  C C   . ASP B 2 66  ? 9.22861   -9.41320  18.17436  1.000 44.92149  ? 398 ASP B C   1 
ATOM   808  O O   . ASP B 2 66  ? 10.43076  -9.28606  18.42718  1.000 46.85361  ? 398 ASP B O   1 
ATOM   809  C CB  . ASP B 2 66  ? 7.92965   -8.23101  19.97246  1.000 45.13142  ? 398 ASP B CB  1 
ATOM   810  C CG  . ASP B 2 66  ? 6.92281   -8.34880  21.10531  1.000 50.14540  ? 398 ASP B CG  1 
ATOM   811  O OD1 . ASP B 2 66  ? 6.05415   -9.24663  21.04469  1.000 49.13258  ? 398 ASP B OD1 1 
ATOM   812  O OD2 . ASP B 2 66  ? 6.99655   -7.54287  22.05596  1.000 45.68594  ? 398 ASP B OD2 1 
ATOM   813  N N   . SER B 2 67  ? 8.74310   -9.43114  16.93102  1.000 45.25776  ? 399 SER B N   1 
ATOM   814  C CA  . SER B 2 67  ? 9.62735   -9.35749  15.77336  1.000 47.69688  ? 399 SER B CA  1 
ATOM   815  C C   . SER B 2 67  ? 9.03600   -8.45711  14.69586  1.000 44.86500  ? 399 SER B C   1 
ATOM   816  O O   . SER B 2 67  ? 7.81663   -8.42056  14.50122  1.000 40.65493  ? 399 SER B O   1 
ATOM   817  C CB  . SER B 2 67  ? 9.91017   -10.75296 15.19599  1.000 38.01058  ? 399 SER B CB  1 
ATOM   818  O OG  . SER B 2 67  ? 8.71156   -11.42931 14.87238  1.000 47.16363  ? 399 SER B OG  1 
ATOM   819  N N   . PHE B 2 68  ? 9.91459   -7.74469  13.99269  1.000 44.90569  ? 400 PHE B N   1 
ATOM   820  C CA  . PHE B 2 68  ? 9.52636   -6.77779  12.96929  1.000 40.67742  ? 400 PHE B CA  1 
ATOM   821  C C   . PHE B 2 68  ? 10.78617  -6.32676  12.23405  1.000 48.55308  ? 400 PHE B C   1 
ATOM   822  O O   . PHE B 2 68  ? 11.91052  -6.65054  12.63031  1.000 41.90172  ? 400 PHE B O   1 
ATOM   823  C CB  . PHE B 2 68  ? 8.78787   -5.58752  13.58354  1.000 38.71952  ? 400 PHE B CB  1 
ATOM   824  C CG  . PHE B 2 68  ? 9.49012   -4.98517  14.76503  1.000 38.54310  ? 400 PHE B CG  1 
ATOM   825  C CD1 . PHE B 2 68  ? 10.51679  -4.07169  14.58985  1.000 35.02538  ? 400 PHE B CD1 1 
ATOM   826  C CD2 . PHE B 2 68  ? 9.12176   -5.33712  16.05562  1.000 40.73740  ? 400 PHE B CD2 1 
ATOM   827  C CE1 . PHE B 2 68  ? 11.16562  -3.52170  15.67991  1.000 38.14506  ? 400 PHE B CE1 1 
ATOM   828  C CE2 . PHE B 2 68  ? 9.76211   -4.79030  17.15028  1.000 39.93927  ? 400 PHE B CE2 1 
ATOM   829  C CZ  . PHE B 2 68  ? 10.78675  -3.88163  16.96354  1.000 42.95243  ? 400 PHE B CZ  1 
ATOM   830  N N   . VAL B 2 69  ? 10.58676  -5.55376  11.16519  1.000 42.04751  ? 401 VAL B N   1 
ATOM   831  C CA  . VAL B 2 69  ? 11.66723  -4.99318  10.35783  1.000 31.10171  ? 401 VAL B CA  1 
ATOM   832  C C   . VAL B 2 69  ? 11.57454  -3.47082  10.40876  1.000 32.78946  ? 401 VAL B C   1 
ATOM   833  O O   . VAL B 2 69  ? 10.47385  -2.90868  10.35344  1.000 35.07159  ? 401 VAL B O   1 
ATOM   834  C CB  . VAL B 2 69  ? 11.60236  -5.49629  8.90296   1.000 41.67665  ? 401 VAL B CB  1 
ATOM   835  C CG1 . VAL B 2 69  ? 12.60210  -4.75111  8.02632   1.000 41.06616  ? 401 VAL B CG1 1 
ATOM   836  C CG2 . VAL B 2 69  ? 11.86026  -6.99329  8.85027   1.000 41.45834  ? 401 VAL B CG2 1 
ATOM   837  N N   . ILE B 2 70  ? 12.72898  -2.80860  10.52120  1.000 29.57891  ? 402 ILE B N   1 
ATOM   838  C CA  . ILE B 2 70  ? 12.84054  -1.35367  10.53710  1.000 34.40805  ? 402 ILE B CA  1 
ATOM   839  C C   . ILE B 2 70  ? 14.14669  -0.96579  9.85072   1.000 39.35488  ? 402 ILE B C   1 
ATOM   840  O O   . ILE B 2 70  ? 14.91558  -1.82127  9.40352   1.000 37.06901  ? 402 ILE B O   1 
ATOM   841  C CB  . ILE B 2 70  ? 12.79203  -0.77028  11.96833  1.000 38.49556  ? 402 ILE B CB  1 
ATOM   842  C CG1 . ILE B 2 70  ? 13.80149  -1.47891  12.87520  1.000 36.75442  ? 402 ILE B CG1 1 
ATOM   843  C CG2 . ILE B 2 70  ? 11.38793  -0.84735  12.54693  1.000 30.74543  ? 402 ILE B CG2 1 
ATOM   844  C CD1 . ILE B 2 70  ? 13.84495  -0.92635  14.29145  1.000 33.71438  ? 402 ILE B CD1 1 
ATOM   845  N N   . ARG B 2 71  ? 14.39709  0.33970   9.77220   1.000 31.76752  ? 403 ARG B N   1 
ATOM   846  C CA  . ARG B 2 71  ? 15.66908  0.83492   9.27094   1.000 36.62223  ? 403 ARG B CA  1 
ATOM   847  C C   . ARG B 2 71  ? 16.77741  0.62409   10.29925  1.000 39.30216  ? 403 ARG B C   1 
ATOM   848  O O   . ARG B 2 71  ? 16.54102  0.58074   11.50994  1.000 40.34888  ? 403 ARG B O   1 
ATOM   849  C CB  . ARG B 2 71  ? 15.58044  2.32485   8.94156   1.000 35.08757  ? 403 ARG B CB  1 
ATOM   850  C CG  . ARG B 2 71  ? 14.80982  2.65833   7.69165   1.000 39.73195  ? 403 ARG B CG  1 
ATOM   851  C CD  . ARG B 2 71  ? 14.20971  4.04916   7.80976   1.000 39.18375  ? 403 ARG B CD  1 
ATOM   852  N NE  . ARG B 2 71  ? 15.22333  5.06702   8.03903   1.000 33.10784  ? 403 ARG B NE  1 
ATOM   853  C CZ  . ARG B 2 71  ? 14.99236  6.37028   7.98519   1.000 40.88772  ? 403 ARG B CZ  1 
ATOM   854  N NH1 . ARG B 2 71  ? 13.79145  6.84807   7.70199   1.000 43.65761  ? 403 ARG B NH1 1 
ATOM   855  N NH2 . ARG B 2 71  ? 15.99198  7.21594   8.21211   1.000 41.48967  ? 403 ARG B NH2 1 
ATOM   856  N N   . GLY B 2 72  ? 18.00986  0.53107   9.79508   1.000 39.77735  ? 404 GLY B N   1 
ATOM   857  C CA  . GLY B 2 72  ? 19.15636  0.40674   10.67951  1.000 41.36878  ? 404 GLY B CA  1 
ATOM   858  C C   . GLY B 2 72  ? 19.27871  1.55873   11.65863  1.000 46.16159  ? 404 GLY B C   1 
ATOM   859  O O   . GLY B 2 72  ? 19.57687  1.35392   12.83782  1.000 48.48145  ? 404 GLY B O   1 
ATOM   860  N N   . ASN B 2 73  ? 19.04504  2.78495   11.18912  1.000 37.88142  ? 405 ASN B N   1 
ATOM   861  C CA  . ASN B 2 73  ? 19.14224  3.94920   12.06128  1.000 39.48017  ? 405 ASN B CA  1 
ATOM   862  C C   . ASN B 2 73  ? 17.98676  4.04983   13.04579  1.000 36.86677  ? 405 ASN B C   1 
ATOM   863  O O   . ASN B 2 73  ? 17.97247  4.98004   13.85826  1.000 38.36670  ? 405 ASN B O   1 
ATOM   864  C CB  . ASN B 2 73  ? 19.17416  5.22776   11.23388  1.000 39.25586  ? 405 ASN B CB  1 
ATOM   865  C CG  . ASN B 2 73  ? 17.80339  5.58079   10.69438  1.000 44.03793  ? 405 ASN B CG  1 
ATOM   866  O OD1 . ASN B 2 73  ? 17.30794  4.92472   9.78317   1.000 41.45139  ? 405 ASN B OD1 1 
ATOM   867  N ND2 . ASN B 2 73  ? 17.16605  6.59294   11.28127  1.000 43.56749  ? 405 ASN B ND2 1 
ATOM   868  N N   . GLU B 2 74  ? 17.00185  3.15807   12.96449  1.000 34.05058  ? 406 GLU B N   1 
ATOM   869  C CA  . GLU B 2 74  ? 15.87141  3.18076   13.87972  1.000 41.59154  ? 406 GLU B CA  1 
ATOM   870  C C   . GLU B 2 74  ? 15.98655  2.13984   14.98673  1.000 39.98345  ? 406 GLU B C   1 
ATOM   871  O O   . GLU B 2 74  ? 15.21056  2.19589   15.94706  1.000 38.97633  ? 406 GLU B O   1 
ATOM   872  C CB  . GLU B 2 74  ? 14.55883  2.98538   13.10106  1.000 34.29366  ? 406 GLU B CB  1 
ATOM   873  C CG  . GLU B 2 74  ? 14.18303  4.18664   12.22909  1.000 38.33968  ? 406 GLU B CG  1 
ATOM   874  C CD  . GLU B 2 74  ? 13.10335  3.87610   11.19835  1.000 39.29305  ? 406 GLU B CD  1 
ATOM   875  O OE1 . GLU B 2 74  ? 12.86004  2.68306   10.90947  1.000 33.67843  ? 406 GLU B OE1 1 
ATOM   876  O OE2 . GLU B 2 74  ? 12.49493  4.83448   10.67582  1.000 37.17802  ? 406 GLU B OE2 1 
ATOM   877  N N   . VAL B 2 75  ? 16.94736  1.21388   14.88432  1.000 36.56701  ? 407 VAL B N   1 
ATOM   878  C CA  . VAL B 2 75  ? 17.11835  0.17024   15.89426  1.000 42.63724  ? 407 VAL B CA  1 
ATOM   879  C C   . VAL B 2 75  ? 17.36342  0.77354   17.27080  1.000 41.29929  ? 407 VAL B C   1 
ATOM   880  O O   . VAL B 2 75  ? 16.89324  0.23961   18.28284  1.000 44.33794  ? 407 VAL B O   1 
ATOM   881  C CB  . VAL B 2 75  ? 18.25983  -0.78560  15.48734  1.000 43.54263  ? 407 VAL B CB  1 
ATOM   882  C CG1 . VAL B 2 75  ? 18.47883  -1.84172  16.55957  1.000 34.91954  ? 407 VAL B CG1 1 
ATOM   883  C CG2 . VAL B 2 75  ? 17.95467  -1.43772  14.14584  1.000 38.81508  ? 407 VAL B CG2 1 
ATOM   884  N N   . SER B 2 76  ? 18.07373  1.90296   17.33445  1.000 39.56808  ? 408 SER B N   1 
ATOM   885  C CA  . SER B 2 76  ? 18.32562  2.55283   18.61543  1.000 40.99433  ? 408 SER B CA  1 
ATOM   886  C C   . SER B 2 76  ? 17.04359  2.99461   19.30808  1.000 46.02143  ? 408 SER B C   1 
ATOM   887  O O   . SER B 2 76  ? 17.07890  3.30584   20.50366  1.000 44.09334  ? 408 SER B O   1 
ATOM   888  C CB  . SER B 2 76  ? 19.24509  3.75990   18.42694  1.000 40.95931  ? 408 SER B CB  1 
ATOM   889  O OG  . SER B 2 76  ? 18.61450  4.76256   17.64747  1.000 45.96121  ? 408 SER B OG  1 
ATOM   890  N N   . GLN B 2 77  ? 15.91651  3.03904   18.59066  1.000 41.70436  ? 409 GLN B N   1 
ATOM   891  C CA  . GLN B 2 77  ? 14.64520  3.38001   19.21806  1.000 42.25720  ? 409 GLN B CA  1 
ATOM   892  C C   . GLN B 2 77  ? 14.01164  2.19693   19.93789  1.000 39.75882  ? 409 GLN B C   1 
ATOM   893  O O   . GLN B 2 77  ? 13.09965  2.39590   20.74750  1.000 37.62109  ? 409 GLN B O   1 
ATOM   894  C CB  . GLN B 2 77  ? 13.66391  3.93190   18.17799  1.000 33.85707  ? 409 GLN B CB  1 
ATOM   895  C CG  . GLN B 2 77  ? 14.04936  5.29319   17.60460  1.000 38.54367  ? 409 GLN B CG  1 
ATOM   896  C CD  . GLN B 2 77  ? 12.99438  5.85039   16.65585  1.000 41.99769  ? 409 GLN B CD  1 
ATOM   897  O OE1 . GLN B 2 77  ? 11.79102  5.68968   16.88051  1.000 40.73181  ? 409 GLN B OE1 1 
ATOM   898  N NE2 . GLN B 2 77  ? 13.44371  6.50249   15.58594  1.000 33.94755  ? 409 GLN B NE2 1 
ATOM   899  N N   . ILE B 2 78  ? 14.46137  0.97625   19.65972  1.000 36.65507  ? 410 ILE B N   1 
ATOM   900  C CA  . ILE B 2 78  ? 13.91941  -0.20213  20.32604  1.000 37.56136  ? 410 ILE B CA  1 
ATOM   901  C C   . ILE B 2 78  ? 14.65572  -0.37797  21.64772  1.000 44.66353  ? 410 ILE B C   1 
ATOM   902  O O   . ILE B 2 78  ? 15.42441  -1.32827  21.83088  1.000 42.79888  ? 410 ILE B O   1 
ATOM   903  C CB  . ILE B 2 78  ? 14.03364  -1.45241  19.43598  1.000 42.55127  ? 410 ILE B CB  1 
ATOM   904  C CG1 . ILE B 2 78  ? 13.61843  -1.11703  17.99713  1.000 43.41988  ? 410 ILE B CG1 1 
ATOM   905  C CG2 . ILE B 2 78  ? 13.17116  -2.58128  19.99093  1.000 36.74242  ? 410 ILE B CG2 1 
ATOM   906  C CD1 . ILE B 2 78  ? 12.17324  -0.63635  17.86362  1.000 31.98574  ? 410 ILE B CD1 1 
ATOM   907  N N   . ALA B 2 79  ? 14.42628  0.54956   22.56879  1.000 42.37401  ? 411 ALA B N   1 
ATOM   908  C CA  . ALA B 2 79  ? 15.09995  0.58045   23.85555  1.000 44.32483  ? 411 ALA B CA  1 
ATOM   909  C C   . ALA B 2 79  ? 14.23111  1.37332   24.81429  1.000 45.09717  ? 411 ALA B C   1 
ATOM   910  O O   . ALA B 2 79  ? 13.42517  2.20473   24.37731  1.000 44.77808  ? 411 ALA B O   1 
ATOM   911  C CB  . ALA B 2 79  ? 16.49506  1.21478   23.73647  1.000 40.54273  ? 411 ALA B CB  1 
ATOM   912  N N   . PRO B 2 80  ? 14.35747  1.13722   26.11903  1.000 44.63795  ? 412 PRO B N   1 
ATOM   913  C CA  . PRO B 2 80  ? 13.53795  1.88975   27.07703  1.000 39.65990  ? 412 PRO B CA  1 
ATOM   914  C C   . PRO B 2 80  ? 13.89910  3.36703   27.07290  1.000 36.31763  ? 412 PRO B C   1 
ATOM   915  O O   . PRO B 2 80  ? 15.06422  3.74092   26.92005  1.000 42.63685  ? 412 PRO B O   1 
ATOM   916  C CB  . PRO B 2 80  ? 13.86397  1.23156   28.42617  1.000 42.37172  ? 412 PRO B CB  1 
ATOM   917  C CG  . PRO B 2 80  ? 15.17092  0.54440   28.22077  1.000 43.12269  ? 412 PRO B CG  1 
ATOM   918  C CD  . PRO B 2 80  ? 15.19127  0.11815   26.78070  1.000 47.31445  ? 412 PRO B CD  1 
ATOM   919  N N   . GLY B 2 81  ? 12.87650  4.20746   27.21910  1.000 37.70668  ? 413 GLY B N   1 
ATOM   920  C CA  . GLY B 2 81  ? 13.07853  5.63934   27.30093  1.000 35.63993  ? 413 GLY B CA  1 
ATOM   921  C C   . GLY B 2 81  ? 13.35846  6.34420   25.99177  1.000 47.23493  ? 413 GLY B C   1 
ATOM   922  O O   . GLY B 2 81  ? 13.80096  7.49598   26.00822  1.000 49.26583  ? 413 GLY B O   1 
ATOM   923  N N   . GLN B 2 82  ? 13.11610  5.70236   24.85403  1.000 44.75277  ? 414 GLN B N   1 
ATOM   924  C CA  . GLN B 2 82  ? 13.41582  6.30194   23.56077  1.000 45.08649  ? 414 GLN B CA  1 
ATOM   925  C C   . GLN B 2 82  ? 12.18149  6.96934   22.96806  1.000 41.03905  ? 414 GLN B C   1 
ATOM   926  O O   . GLN B 2 82  ? 11.04473  6.57533   23.24091  1.000 45.73421  ? 414 GLN B O   1 
ATOM   927  C CB  . GLN B 2 82  ? 13.95305  5.25655   22.57843  1.000 44.26923  ? 414 GLN B CB  1 
ATOM   928  C CG  . GLN B 2 82  ? 15.27015  4.62548   23.00467  1.000 49.86169  ? 414 GLN B CG  1 
ATOM   929  C CD  . GLN B 2 82  ? 16.39953  5.63470   23.11689  1.000 49.00225  ? 414 GLN B CD  1 
ATOM   930  O OE1 . GLN B 2 82  ? 16.47940  6.58541   22.33991  1.000 55.24869  ? 414 GLN B OE1 1 
ATOM   931  N NE2 . GLN B 2 82  ? 17.27825  5.43179   24.09228  1.000 62.44703  ? 414 GLN B NE2 1 
ATOM   932  N N   . THR B 2 83  ? 12.42301  7.99980   22.16025  1.000 45.53141  ? 415 THR B N   1 
ATOM   933  C CA  . THR B 2 83  ? 11.39388  8.63132   21.35007  1.000 41.16726  ? 415 THR B CA  1 
ATOM   934  C C   . THR B 2 83  ? 11.85636  8.64879   19.89977  1.000 43.33303  ? 415 THR B C   1 
ATOM   935  O O   . THR B 2 83  ? 13.05009  8.55712   19.60545  1.000 39.58859  ? 415 THR B O   1 
ATOM   936  C CB  . THR B 2 83  ? 11.08072  10.06339  21.81277  1.000 41.00660  ? 415 THR B CB  1 
ATOM   937  O OG1 . THR B 2 83  ? 12.22367  10.89897  21.59504  1.000 52.34518  ? 415 THR B OG1 1 
ATOM   938  C CG2 . THR B 2 83  ? 10.71542  10.08492  23.29201  1.000 52.24781  ? 415 THR B CG2 1 
ATOM   939  N N   . GLY B 2 84  ? 10.89702  8.76816   19.00063  1.000 47.38857  ? 416 GLY B N   1 
ATOM   940  C CA  . GLY B 2 84  ? 11.16426  8.73505   17.57551  1.000 36.71023  ? 416 GLY B CA  1 
ATOM   941  C C   . GLY B 2 84  ? 9.93428   8.25070   16.83610  1.000 39.94052  ? 416 GLY B C   1 
ATOM   942  O O   . GLY B 2 84  ? 8.90549   7.94621   17.43027  1.000 36.22894  ? 416 GLY B O   1 
ATOM   943  N N   . ASN B 2 85  ? 10.06215  8.17978   15.50783  1.000 37.73923  ? 417 ASN B N   1 
ATOM   944  C CA  . ASN B 2 85  ? 8.91499   7.76448   14.70696  1.000 35.96157  ? 417 ASN B CA  1 
ATOM   945  C C   . ASN B 2 85  ? 8.49548   6.34074   15.05368  1.000 30.70660  ? 417 ASN B C   1 
ATOM   946  O O   . ASN B 2 85  ? 7.29963   6.03926   15.12692  1.000 33.70459  ? 417 ASN B O   1 
ATOM   947  C CB  . ASN B 2 85  ? 9.21696   7.90113   13.20724  1.000 37.43961  ? 417 ASN B CB  1 
ATOM   948  C CG  . ASN B 2 85  ? 10.31139  6.95568   12.73424  1.000 41.68745  ? 417 ASN B CG  1 
ATOM   949  O OD1 . ASN B 2 85  ? 11.32093  6.76247   13.41454  1.000 44.65340  ? 417 ASN B OD1 1 
ATOM   950  N ND2 . ASN B 2 85  ? 10.11677  6.36479   11.56006  1.000 44.90808  ? 417 ASN B ND2 1 
ATOM   951  N N   . ILE B 2 86  ? 9.46107   5.45289   15.28247  1.000 29.96267  ? 418 ILE B N   1 
ATOM   952  C CA  . ILE B 2 86  ? 9.12964   4.06611   15.59724  1.000 34.60452  ? 418 ILE B CA  1 
ATOM   953  C C   . ILE B 2 86  ? 8.63234   3.93752   17.03635  1.000 35.53427  ? 418 ILE B C   1 
ATOM   954  O O   . ILE B 2 86  ? 7.55321   3.38588   17.28758  1.000 34.12650  ? 418 ILE B O   1 
ATOM   955  C CB  . ILE B 2 86  ? 10.34430  3.15818   15.33245  1.000 34.97920  ? 418 ILE B CB  1 
ATOM   956  C CG1 . ILE B 2 86  ? 10.74681  3.22286   13.85292  1.000 33.92134  ? 418 ILE B CG1 1 
ATOM   957  C CG2 . ILE B 2 86  ? 10.04277  1.72605   15.76543  1.000 30.98164  ? 418 ILE B CG2 1 
ATOM   958  C CD1 . ILE B 2 86  ? 9.63727   2.80432   12.89719  1.000 35.79924  ? 418 ILE B CD1 1 
ATOM   959  N N   . ALA B 2 87  ? 9.40727   4.44826   17.99981  1.000 34.92943  ? 419 ALA B N   1 
ATOM   960  C CA  . ALA B 2 87  ? 9.00189   4.36347   19.40270  1.000 37.93682  ? 419 ALA B CA  1 
ATOM   961  C C   . ALA B 2 87  ? 7.60945   4.94423   19.62068  1.000 33.91353  ? 419 ALA B C   1 
ATOM   962  O O   . ALA B 2 87  ? 6.77366   4.33194   20.29511  1.000 34.27796  ? 419 ALA B O   1 
ATOM   963  C CB  . ALA B 2 87  ? 10.02047  5.07771   20.28973  1.000 34.09368  ? 419 ALA B CB  1 
ATOM   964  N N   . ASP B 2 88  ? 7.33067   6.10891   19.02697  1.000 39.06271  ? 420 ASP B N   1 
ATOM   965  C CA  . ASP B 2 88  ? 6.07290   6.80521   19.28297  1.000 33.98110  ? 420 ASP B CA  1 
ATOM   966  C C   . ASP B 2 88  ? 4.88032   6.14078   18.60133  1.000 35.15355  ? 420 ASP B C   1 
ATOM   967  O O   . ASP B 2 88  ? 3.81263   6.01967   19.21107  1.000 37.37227  ? 420 ASP B O   1 
ATOM   968  C CB  . ASP B 2 88  ? 6.16474   8.26420   18.82777  1.000 38.84745  ? 420 ASP B CB  1 
ATOM   969  C CG  . ASP B 2 88  ? 7.19938   9.06411   19.59983  1.000 41.81928  ? 420 ASP B CG  1 
ATOM   970  O OD1 . ASP B 2 88  ? 7.89057   8.49163   20.46496  1.000 37.62852  ? 420 ASP B OD1 1 
ATOM   971  O OD2 . ASP B 2 88  ? 7.32438   10.27595  19.32654  1.000 40.03199  ? 420 ASP B OD2 1 
ATOM   972  N N   . TYR B 2 89  ? 5.01831   5.73456   17.33456  1.000 34.41566  ? 421 TYR B N   1 
ATOM   973  C CA  . TYR B 2 89  ? 3.85791   5.36250   16.53434  1.000 29.15163  ? 421 TYR B CA  1 
ATOM   974  C C   . TYR B 2 89  ? 3.80335   3.88871   16.15554  1.000 29.91237  ? 421 TYR B C   1 
ATOM   975  O O   . TYR B 2 89  ? 2.77732   3.44753   15.63018  1.000 32.22612  ? 421 TYR B O   1 
ATOM   976  C CB  . TYR B 2 89  ? 3.79961   6.21360   15.25354  1.000 30.40489  ? 421 TYR B CB  1 
ATOM   977  C CG  . TYR B 2 89  ? 3.76662   7.71154   15.48684  1.000 33.78694  ? 421 TYR B CG  1 
ATOM   978  C CD1 . TYR B 2 89  ? 3.27058   8.24516   16.67418  1.000 33.29028  ? 421 TYR B CD1 1 
ATOM   979  C CD2 . TYR B 2 89  ? 4.22806   8.59540   14.51308  1.000 34.78398  ? 421 TYR B CD2 1 
ATOM   980  C CE1 . TYR B 2 89  ? 3.23879   9.61602   16.89069  1.000 33.01561  ? 421 TYR B CE1 1 
ATOM   981  C CE2 . TYR B 2 89  ? 4.20101   9.97090   14.72237  1.000 37.34983  ? 421 TYR B CE2 1 
ATOM   982  C CZ  . TYR B 2 89  ? 3.70502   10.47081  15.91290  1.000 37.62467  ? 421 TYR B CZ  1 
ATOM   983  O OH  . TYR B 2 89  ? 3.67269   11.82968  16.12576  1.000 36.45475  ? 421 TYR B OH  1 
ATOM   984  N N   . ASN B 2 90  ? 4.85159   3.11052   16.41669  1.000 28.39694  ? 422 ASN B N   1 
ATOM   985  C CA  . ASN B 2 90  ? 4.93324   1.75740   15.87912  1.000 30.62054  ? 422 ASN B CA  1 
ATOM   986  C C   . ASN B 2 90  ? 5.16777   0.70360   16.95057  1.000 34.86048  ? 422 ASN B C   1 
ATOM   987  O O   . ASN B 2 90  ? 4.32018   -0.17471  17.12334  1.000 37.00134  ? 422 ASN B O   1 
ATOM   988  C CB  . ASN B 2 90  ? 6.02866   1.72019   14.80899  1.000 28.49429  ? 422 ASN B CB  1 
ATOM   989  C CG  . ASN B 2 90  ? 5.62917   2.46069   13.54736  1.000 35.96500  ? 422 ASN B CG  1 
ATOM   990  O OD1 . ASN B 2 90  ? 5.12545   1.85766   12.60378  1.000 35.86175  ? 422 ASN B OD1 1 
ATOM   991  N ND2 . ASN B 2 90  ? 5.83432   3.77431   13.53305  1.000 32.38638  ? 422 ASN B ND2 1 
ATOM   992  N N   . TYR B 2 91  ? 6.28684   0.74664   17.67399  1.000 34.45381  ? 423 TYR B N   1 
ATOM   993  C CA  . TYR B 2 91  ? 6.57829   -0.24113  18.70911  1.000 40.33799  ? 423 TYR B CA  1 
ATOM   994  C C   . TYR B 2 91  ? 7.23958   0.46047   19.88672  1.000 34.58455  ? 423 TYR B C   1 
ATOM   995  O O   . TYR B 2 91  ? 8.28100   1.10288   19.72139  1.000 39.06250  ? 423 TYR B O   1 
ATOM   996  C CB  . TYR B 2 91  ? 7.47623   -1.35555  18.16376  1.000 38.11934  ? 423 TYR B CB  1 
ATOM   997  C CG  . TYR B 2 91  ? 7.72843   -2.46199  19.16295  1.000 39.02854  ? 423 TYR B CG  1 
ATOM   998  C CD1 . TYR B 2 91  ? 6.81415   -3.49908  19.32670  1.000 39.68144  ? 423 TYR B CD1 1 
ATOM   999  C CD2 . TYR B 2 91  ? 8.88066   -2.46957  19.94622  1.000 41.45752  ? 423 TYR B CD2 1 
ATOM   1000 C CE1 . TYR B 2 91  ? 7.04158   -4.51057  20.23831  1.000 39.25139  ? 423 TYR B CE1 1 
ATOM   1001 C CE2 . TYR B 2 91  ? 9.11443   -3.47630  20.86185  1.000 42.59318  ? 423 TYR B CE2 1 
ATOM   1002 C CZ  . TYR B 2 91  ? 8.19297   -4.49334  21.00633  1.000 41.96344  ? 423 TYR B CZ  1 
ATOM   1003 O OH  . TYR B 2 91  ? 8.42931   -5.49880  21.91900  1.000 48.62982  ? 423 TYR B OH  1 
ATOM   1004 N N   . LYS B 2 92  ? 6.65045   0.32615   21.07362  1.000 37.44369  ? 424 LYS B N   1 
ATOM   1005 C CA  . LYS B 2 92  ? 7.07187   1.09203   22.24288  1.000 39.81218  ? 424 LYS B CA  1 
ATOM   1006 C C   . LYS B 2 92  ? 7.37206   0.17169   23.41832  1.000 39.22910  ? 424 LYS B C   1 
ATOM   1007 O O   . LYS B 2 92  ? 6.50730   -0.60275  23.84221  1.000 34.66995  ? 424 LYS B O   1 
ATOM   1008 C CB  . LYS B 2 92  ? 5.99524   2.10909   22.64305  1.000 37.54165  ? 424 LYS B CB  1 
ATOM   1009 C CG  . LYS B 2 92  ? 6.34003   2.93630   23.87418  1.000 39.39240  ? 424 LYS B CG  1 
ATOM   1010 C CD  . LYS B 2 92  ? 7.60827   3.75224   23.66009  1.000 39.68452  ? 424 LYS B CD  1 
ATOM   1011 C CE  . LYS B 2 92  ? 7.90978   4.63957   24.85953  1.000 39.20528  ? 424 LYS B CE  1 
ATOM   1012 N NZ  . LYS B 2 92  ? 9.14296   5.44785   24.63980  1.000 38.91629  ? 424 LYS B NZ  1 
ATOM   1013 N N   . LEU B 2 93  ? 8.59331   0.27628   23.95512  1.000 41.91749  ? 425 LEU B N   1 
ATOM   1014 C CA  . LEU B 2 93  ? 9.06229   -0.42074  25.14722  1.000 38.05059  ? 425 LEU B CA  1 
ATOM   1015 C C   . LEU B 2 93  ? 8.88618   0.45207   26.38396  1.000 39.35325  ? 425 LEU B C   1 
ATOM   1016 O O   . LEU B 2 93  ? 9.08704   1.67159   26.32210  1.000 39.04850  ? 425 LEU B O   1 
ATOM   1017 C CB  . LEU B 2 93  ? 10.53616  -0.81079  25.01693  1.000 34.97431  ? 425 LEU B CB  1 
ATOM   1018 C CG  . LEU B 2 93  ? 10.91037  -1.92113  24.03525  1.000 37.77566  ? 425 LEU B CG  1 
ATOM   1019 C CD1 . LEU B 2 93  ? 12.38840  -2.26051  24.16948  1.000 38.61423  ? 425 LEU B CD1 1 
ATOM   1020 C CD2 . LEU B 2 93  ? 10.05048  -3.15663  24.25006  1.000 35.38327  ? 425 LEU B CD2 1 
ATOM   1021 N N   . PRO B 2 94  ? 8.51574   -0.14430  27.51226  1.000 43.23158  ? 426 PRO B N   1 
ATOM   1022 C CA  . PRO B 2 94  ? 8.36473   0.63516   28.74523  1.000 42.54712  ? 426 PRO B CA  1 
ATOM   1023 C C   . PRO B 2 94  ? 9.70823   1.11729   29.27321  1.000 42.24049  ? 426 PRO B C   1 
ATOM   1024 O O   . PRO B 2 94  ? 10.76860  0.57350   28.95817  1.000 44.01403  ? 426 PRO B O   1 
ATOM   1025 C CB  . PRO B 2 94  ? 7.71245   -0.35790  29.71187  1.000 39.73720  ? 426 PRO B CB  1 
ATOM   1026 C CG  . PRO B 2 94  ? 8.15911   -1.69536  29.22143  1.000 38.16458  ? 426 PRO B CG  1 
ATOM   1027 C CD  . PRO B 2 94  ? 8.23310   -1.57449  27.72026  1.000 44.24596  ? 426 PRO B CD  1 
ATOM   1028 N N   . ASP B 2 95  ? 9.64841   2.16830   30.09449  1.000 41.23410  ? 427 ASP B N   1 
ATOM   1029 C CA  . ASP B 2 95  ? 10.86792  2.69535   30.69878  1.000 48.61955  ? 427 ASP B CA  1 
ATOM   1030 C C   . ASP B 2 95  ? 11.55900  1.65981   31.57994  1.000 49.69911  ? 427 ASP B C   1 
ATOM   1031 O O   . ASP B 2 95  ? 12.79068  1.66689   31.69419  1.000 48.90275  ? 427 ASP B O   1 
ATOM   1032 C CB  . ASP B 2 95  ? 10.55686  3.95140   31.51331  1.000 49.40639  ? 427 ASP B CB  1 
ATOM   1033 C CG  . ASP B 2 95  ? 10.07640  5.10871   30.65205  1.000 52.57987  ? 427 ASP B CG  1 
ATOM   1034 O OD1 . ASP B 2 95  ? 9.82706   4.89678   29.44483  1.000 50.20635  ? 427 ASP B OD1 1 
ATOM   1035 O OD2 . ASP B 2 95  ? 9.94905   6.23334   31.18806  1.000 52.46551  ? 427 ASP B OD2 1 
ATOM   1036 N N   . ASP B 2 96  ? 10.79386  0.76423   32.20655  1.000 47.38878  ? 428 ASP B N   1 
ATOM   1037 C CA  . ASP B 2 96  ? 11.34738  -0.24277  33.10511  1.000 53.12989  ? 428 ASP B CA  1 
ATOM   1038 C C   . ASP B 2 96  ? 11.56401  -1.58302  32.40944  1.000 51.21003  ? 428 ASP B C   1 
ATOM   1039 O O   . ASP B 2 96  ? 11.49833  -2.63498  33.05312  1.000 56.81808  ? 428 ASP B O   1 
ATOM   1040 C CB  . ASP B 2 96  ? 10.44850  -0.41908  34.33009  1.000 41.21144  ? 428 ASP B CB  1 
ATOM   1041 C CG  . ASP B 2 96  ? 9.06241   -0.92071  33.97119  1.000 53.63179  ? 428 ASP B CG  1 
ATOM   1042 O OD1 . ASP B 2 96  ? 8.74187   -1.00521  32.76651  1.000 55.58828  ? 428 ASP B OD1 1 
ATOM   1043 O OD2 . ASP B 2 96  ? 8.28882   -1.23662  34.89653  1.000 55.17669  ? 428 ASP B OD2 1 
ATOM   1044 N N   . PHE B 2 97  ? 11.81171  -1.56649  31.10304  1.000 53.41465  ? 429 PHE B N   1 
ATOM   1045 C CA  . PHE B 2 97  ? 12.02995  -2.80338  30.36275  1.000 51.12718  ? 429 PHE B CA  1 
ATOM   1046 C C   . PHE B 2 97  ? 13.29689  -3.49653  30.84978  1.000 49.27998  ? 429 PHE B C   1 
ATOM   1047 O O   . PHE B 2 97  ? 14.34073  -2.85615  31.00947  1.000 47.86087  ? 429 PHE B O   1 
ATOM   1048 C CB  . PHE B 2 97  ? 12.12889  -2.50023  28.86670  1.000 45.29430  ? 429 PHE B CB  1 
ATOM   1049 C CG  . PHE B 2 97  ? 12.33009  -3.71141  28.00979  1.000 40.80303  ? 429 PHE B CG  1 
ATOM   1050 C CD1 . PHE B 2 97  ? 11.28111  -4.58460  27.76588  1.000 43.22423  ? 429 PHE B CD1 1 
ATOM   1051 C CD2 . PHE B 2 97  ? 13.56373  -3.97368  27.43683  1.000 41.40601  ? 429 PHE B CD2 1 
ATOM   1052 C CE1 . PHE B 2 97  ? 11.46007  -5.70431  26.97010  1.000 41.59251  ? 429 PHE B CE1 1 
ATOM   1053 C CE2 . PHE B 2 97  ? 13.74767  -5.08709  26.64074  1.000 39.92457  ? 429 PHE B CE2 1 
ATOM   1054 C CZ  . PHE B 2 97  ? 12.69213  -5.95223  26.40599  1.000 39.20122  ? 429 PHE B CZ  1 
ATOM   1055 N N   . THR B 2 98  ? 13.21083  -4.81126  31.08282  1.000 46.79558  ? 430 THR B N   1 
ATOM   1056 C CA  . THR B 2 98  ? 14.36254  -5.57552  31.55766  1.000 58.92205  ? 430 THR B CA  1 
ATOM   1057 C C   . THR B 2 98  ? 14.59891  -6.82667  30.71578  1.000 61.24988  ? 430 THR B C   1 
ATOM   1058 O O   . THR B 2 98  ? 15.20276  -7.79306  31.19316  1.000 62.97070  ? 430 THR B O   1 
ATOM   1059 C CB  . THR B 2 98  ? 14.21405  -5.95573  33.03451  1.000 53.64938  ? 430 THR B CB  1 
ATOM   1060 O OG1 . THR B 2 98  ? 13.00163  -6.69484  33.22958  1.000 50.72561  ? 430 THR B OG1 1 
ATOM   1061 C CG2 . THR B 2 98  ? 14.19965  -4.71034  33.91508  1.000 52.18735  ? 430 THR B CG2 1 
ATOM   1062 N N   . GLY B 2 99  ? 14.13517  -6.83177  29.46905  1.000 49.20251  ? 431 GLY B N   1 
ATOM   1063 C CA  . GLY B 2 99  ? 14.35413  -7.94352  28.55994  1.000 41.86749  ? 431 GLY B CA  1 
ATOM   1064 C C   . GLY B 2 99  ? 15.56579  -7.74595  27.67240  1.000 50.12708  ? 431 GLY B C   1 
ATOM   1065 O O   . GLY B 2 99  ? 16.51512  -7.03722  28.02212  1.000 50.79042  ? 431 GLY B O   1 
ATOM   1066 N N   . CYS B 2 100 ? 15.53519  -8.37835  26.49839  1.000 49.37816  ? 432 CYS B N   1 
ATOM   1067 C CA  . CYS B 2 100 ? 16.64701  -8.31864  25.55741  1.000 57.67118  ? 432 CYS B CA  1 
ATOM   1068 C C   . CYS B 2 100 ? 16.15905  -7.87805  24.18418  1.000 48.84725  ? 432 CYS B C   1 
ATOM   1069 O O   . CYS B 2 100 ? 15.07624  -8.27277  23.74042  1.000 45.13801  ? 432 CYS B O   1 
ATOM   1070 C CB  . CYS B 2 100 ? 17.35665  -9.67761  25.43914  1.000 54.71061  ? 432 CYS B CB  1 
ATOM   1071 S SG  . CYS B 2 100 ? 17.91680  -10.39224 27.01202  1.000 64.41101  ? 432 CYS B SG  1 
ATOM   1072 N N   . VAL B 2 101 ? 16.97054  -7.06281  23.51576  1.000 49.33758  ? 433 VAL B N   1 
ATOM   1073 C CA  . VAL B 2 101 ? 16.70449  -6.59775  22.15925  1.000 53.87765  ? 433 VAL B CA  1 
ATOM   1074 C C   . VAL B 2 101 ? 17.80582  -7.13099  21.25495  1.000 54.57644  ? 433 VAL B C   1 
ATOM   1075 O O   . VAL B 2 101 ? 18.99343  -6.94272  21.54262  1.000 56.40860  ? 433 VAL B O   1 
ATOM   1076 C CB  . VAL B 2 101 ? 16.63205  -5.06107  22.08445  1.000 53.46251  ? 433 VAL B CB  1 
ATOM   1077 C CG1 . VAL B 2 101 ? 16.45143  -4.60809  20.64175  1.000 48.05661  ? 433 VAL B CG1 1 
ATOM   1078 C CG2 . VAL B 2 101 ? 15.50316  -4.54141  22.95636  1.000 44.81702  ? 433 VAL B CG2 1 
ATOM   1079 N N   . ILE B 2 102 ? 17.41033  -7.79548  20.16899  1.000 47.36372  ? 434 ILE B N   1 
ATOM   1080 C CA  . ILE B 2 102 ? 18.33148  -8.41840  19.22385  1.000 51.29830  ? 434 ILE B CA  1 
ATOM   1081 C C   . ILE B 2 102 ? 17.98739  -7.92789  17.82198  1.000 48.39496  ? 434 ILE B C   1 
ATOM   1082 O O   . ILE B 2 102 ? 16.82922  -8.01466  17.39897  1.000 50.13654  ? 434 ILE B O   1 
ATOM   1083 C CB  . ILE B 2 102 ? 18.24942  -9.95627  19.28806  1.000 55.45952  ? 434 ILE B CB  1 
ATOM   1084 C CG1 . ILE B 2 102 ? 18.46547  -10.44846 20.72193  1.000 56.08374  ? 434 ILE B CG1 1 
ATOM   1085 C CG2 . ILE B 2 102 ? 19.24680  -10.59047 18.33424  1.000 51.73723  ? 434 ILE B CG2 1 
ATOM   1086 C CD1 . ILE B 2 102 ? 18.25876  -11.93370 20.89334  1.000 59.07713  ? 434 ILE B CD1 1 
ATOM   1087 N N   . ALA B 2 103 ? 18.98671  -7.42587  17.09754  1.000 46.17904  ? 435 ALA B N   1 
ATOM   1088 C CA  . ALA B 2 103 ? 18.76574  -6.92680  15.74641  1.000 48.07588  ? 435 ALA B CA  1 
ATOM   1089 C C   . ALA B 2 103 ? 19.94159  -7.29401  14.85446  1.000 48.87618  ? 435 ALA B C   1 
ATOM   1090 O O   . ALA B 2 103 ? 21.08606  -7.37230  15.30895  1.000 52.65777  ? 435 ALA B O   1 
ATOM   1091 C CB  . ALA B 2 103 ? 18.55790  -5.40892  15.72868  1.000 44.53887  ? 435 ALA B CB  1 
ATOM   1092 N N   . TRP B 2 104 ? 19.64915  -7.50470  13.57143  1.000 45.65746  ? 436 TRP B N   1 
ATOM   1093 C CA  . TRP B 2 104 ? 20.68209  -7.85873  12.60997  1.000 47.95874  ? 436 TRP B CA  1 
ATOM   1094 C C   . TRP B 2 104 ? 20.29112  -7.36246  11.22159  1.000 48.22356  ? 436 TRP B C   1 
ATOM   1095 O O   . TRP B 2 104 ? 19.11047  -7.32795  10.86247  1.000 41.37040  ? 436 TRP B O   1 
ATOM   1096 C CB  . TRP B 2 104 ? 20.93511  -9.37381  12.59463  1.000 45.43408  ? 436 TRP B CB  1 
ATOM   1097 C CG  . TRP B 2 104 ? 19.77329  -10.19690 12.11532  1.000 48.20918  ? 436 TRP B CG  1 
ATOM   1098 C CD1 . TRP B 2 104 ? 19.53913  -10.61179 10.83595  1.000 44.25856  ? 436 TRP B CD1 1 
ATOM   1099 C CD2 . TRP B 2 104 ? 18.69618  -10.71710 12.90764  1.000 49.06682  ? 436 TRP B CD2 1 
ATOM   1100 N NE1 . TRP B 2 104 ? 18.38306  -11.35160 10.77937  1.000 42.45115  ? 436 TRP B NE1 1 
ATOM   1101 C CE2 . TRP B 2 104 ? 17.84577  -11.43180 12.03722  1.000 49.53882  ? 436 TRP B CE2 1 
ATOM   1102 C CE3 . TRP B 2 104 ? 18.36557  -10.64458 14.26522  1.000 48.48741  ? 436 TRP B CE3 1 
ATOM   1103 C CZ2 . TRP B 2 104 ? 16.68823  -12.06954 12.47960  1.000 46.53471  ? 436 TRP B CZ2 1 
ATOM   1104 C CZ3 . TRP B 2 104 ? 17.21611  -11.28003 14.70266  1.000 47.90729  ? 436 TRP B CZ3 1 
ATOM   1105 C CH2 . TRP B 2 104 ? 16.39165  -11.98330 13.81206  1.000 53.08186  ? 436 TRP B CH2 1 
ATOM   1106 N N   . ASN B 2 105 ? 21.30484  -6.97665  10.44919  1.000 42.75670  ? 437 ASN B N   1 
ATOM   1107 C CA  . ASN B 2 105 ? 21.09963  -6.49448  9.08856   1.000 43.94426  ? 437 ASN B CA  1 
ATOM   1108 C C   . ASN B 2 105 ? 20.51454  -7.59833  8.21375   1.000 46.34282  ? 437 ASN B C   1 
ATOM   1109 O O   . ASN B 2 105 ? 21.02523  -8.72202  8.18965   1.000 49.27539  ? 437 ASN B O   1 
ATOM   1110 C CB  . ASN B 2 105 ? 22.42849  -5.99759  8.51527   1.000 43.61956  ? 437 ASN B CB  1 
ATOM   1111 C CG  . ASN B 2 105 ? 22.28548  -5.36852  7.13811   1.000 45.87777  ? 437 ASN B CG  1 
ATOM   1112 O OD1 . ASN B 2 105 ? 21.79574  -5.99563  6.20009   1.000 35.99589  ? 437 ASN B OD1 1 
ATOM   1113 N ND2 . ASN B 2 105 ? 22.72527  -4.11835  7.01259   1.000 40.72698  ? 437 ASN B ND2 1 
ATOM   1114 N N   . SER B 2 106 ? 19.44551  -7.27559  7.48668   1.000 42.43677  ? 438 SER B N   1 
ATOM   1115 C CA  . SER B 2 106 ? 18.75218  -8.23974  6.63642   1.000 46.32785  ? 438 SER B CA  1 
ATOM   1116 C C   . SER B 2 106 ? 18.66091  -7.74059  5.19878   1.000 41.96962  ? 438 SER B C   1 
ATOM   1117 O O   . SER B 2 106 ? 17.70668  -8.04834  4.47569   1.000 40.95632  ? 438 SER B O   1 
ATOM   1118 C CB  . SER B 2 106 ? 17.36141  -8.54830  7.18522   1.000 46.18223  ? 438 SER B CB  1 
ATOM   1119 O OG  . SER B 2 106 ? 16.58541  -7.36795  7.31641   1.000 42.63041  ? 438 SER B OG  1 
ATOM   1120 N N   . ASN B 2 107 ? 19.66875  -6.97971  4.75843   1.000 41.56772  ? 439 ASN B N   1 
ATOM   1121 C CA  . ASN B 2 107 ? 19.63519  -6.38870  3.42133   1.000 44.56903  ? 439 ASN B CA  1 
ATOM   1122 C C   . ASN B 2 107 ? 19.43129  -7.44638  2.34150   1.000 49.16170  ? 439 ASN B C   1 
ATOM   1123 O O   . ASN B 2 107 ? 18.63407  -7.25407  1.41547   1.000 48.38324  ? 439 ASN B O   1 
ATOM   1124 C CB  . ASN B 2 107 ? 20.92436  -5.60836  3.15616   1.000 41.89388  ? 439 ASN B CB  1 
ATOM   1125 C CG  . ASN B 2 107 ? 20.82185  -4.70674  1.93324   1.000 50.06544  ? 439 ASN B CG  1 
ATOM   1126 O OD1 . ASN B 2 107 ? 19.77517  -4.11579  1.67348   1.000 45.88630  ? 439 ASN B OD1 1 
ATOM   1127 N ND2 . ASN B 2 107 ? 21.91129  -4.59826  1.17846   1.000 52.78549  ? 439 ASN B ND2 1 
ATOM   1128 N N   . LYS B 2 108 ? 20.13132  -8.57438  2.44541   1.000 48.13504  ? 440 LYS B N   1 
ATOM   1129 C CA  . LYS B 2 108 ? 20.08236  -9.57134  1.38527   1.000 50.79051  ? 440 LYS B CA  1 
ATOM   1130 C C   . LYS B 2 108 ? 18.76408  -10.33305 1.34121   1.000 50.92083  ? 440 LYS B C   1 
ATOM   1131 O O   . LYS B 2 108 ? 18.49886  -11.01575 0.34604   1.000 53.66245  ? 440 LYS B O   1 
ATOM   1132 C CB  . LYS B 2 108 ? 21.25075  -10.55375 1.52912   1.000 51.43943  ? 440 LYS B CB  1 
ATOM   1133 C CG  . LYS B 2 108 ? 22.62805  -9.88480  1.63263   1.000 57.17452  ? 440 LYS B CG  1 
ATOM   1134 C CD  . LYS B 2 108 ? 22.81977  -8.77203  0.59068   1.000 68.60942  ? 440 LYS B CD  1 
ATOM   1135 C CE  . LYS B 2 108 ? 22.81106  -9.30474  -0.84395  1.000 69.48844  ? 440 LYS B CE  1 
ATOM   1136 N NZ  . LYS B 2 108 ? 22.82872  -8.20147  -1.84866  1.000 69.22712  ? 440 LYS B NZ  1 
ATOM   1137 N N   . LEU B 2 109 ? 17.93262  -10.22645 2.37504   1.000 49.96435  ? 441 LEU B N   1 
ATOM   1138 C CA  . LEU B 2 109 ? 16.64634  -10.91420 2.43454   1.000 48.59148  ? 441 LEU B CA  1 
ATOM   1139 C C   . LEU B 2 109 ? 15.45452  -10.00282 2.19109   1.000 48.72271  ? 441 LEU B C   1 
ATOM   1140 O O   . LEU B 2 109 ? 14.46987  -10.43147 1.58820   1.000 46.37474  ? 441 LEU B O   1 
ATOM   1141 C CB  . LEU B 2 109 ? 16.47394  -11.59038 3.80092   1.000 48.82122  ? 441 LEU B CB  1 
ATOM   1142 C CG  . LEU B 2 109 ? 17.45581  -12.70067 4.16925   1.000 58.50782  ? 441 LEU B CG  1 
ATOM   1143 C CD1 . LEU B 2 109 ? 17.39798  -12.98415 5.66224   1.000 60.71424  ? 441 LEU B CD1 1 
ATOM   1144 C CD2 . LEU B 2 109 ? 17.14469  -13.95778 3.37543   1.000 57.69178  ? 441 LEU B CD2 1 
ATOM   1145 N N   . ASP B 2 110 ? 15.50950  -8.75554  2.65564   1.000 49.23230  ? 442 ASP B N   1 
ATOM   1146 C CA  . ASP B 2 110 ? 14.34596  -7.88378  2.65495   1.000 48.81994  ? 442 ASP B CA  1 
ATOM   1147 C C   . ASP B 2 110 ? 14.44078  -6.73457  1.66563   1.000 47.17676  ? 442 ASP B C   1 
ATOM   1148 O O   . ASP B 2 110 ? 13.44474  -6.02842  1.47418   1.000 49.75281  ? 442 ASP B O   1 
ATOM   1149 C CB  . ASP B 2 110 ? 14.10725  -7.31851  4.06399   1.000 46.26547  ? 442 ASP B CB  1 
ATOM   1150 C CG  . ASP B 2 110 ? 13.70838  -8.38847  5.05752   1.000 44.70356  ? 442 ASP B CG  1 
ATOM   1151 O OD1 . ASP B 2 110 ? 13.00613  -9.33988  4.65451   1.000 42.09660  ? 442 ASP B OD1 1 
ATOM   1152 O OD2 . ASP B 2 110 ? 14.09657  -8.28112  6.23820   1.000 44.80418  ? 442 ASP B OD2 1 
ATOM   1153 N N   . SER B 2 111 ? 15.59695  -6.51683  1.04838   1.000 41.48484  ? 443 SER B N   1 
ATOM   1154 C CA  . SER B 2 111 ? 15.71467  -5.52472  -0.00864  1.000 45.28722  ? 443 SER B CA  1 
ATOM   1155 C C   . SER B 2 111 ? 15.46560  -6.16931  -1.36546  1.000 48.20518  ? 443 SER B C   1 
ATOM   1156 O O   . SER B 2 111 ? 15.70323  -7.36364  -1.56185  1.000 50.61997  ? 443 SER B O   1 
ATOM   1157 C CB  . SER B 2 111 ? 17.09149  -4.86262  0.00710   1.000 41.47711  ? 443 SER B CB  1 
ATOM   1158 O OG  . SER B 2 111 ? 17.26257  -4.08439  1.17861   1.000 52.56499  ? 443 SER B OG  1 
ATOM   1159 N N   . LYS B 2 112 ? 14.96909  -5.36368  -2.30067  1.000 43.44372  ? 444 LYS B N   1 
ATOM   1160 C CA  . LYS B 2 112 ? 14.68235  -5.81875  -3.65197  1.000 44.50841  ? 444 LYS B CA  1 
ATOM   1161 C C   . LYS B 2 112 ? 15.04952  -4.71413  -4.62542  1.000 41.84682  ? 444 LYS B C   1 
ATOM   1162 O O   . LYS B 2 112 ? 14.79229  -3.53578  -4.35913  1.000 42.28122  ? 444 LYS B O   1 
ATOM   1163 C CB  . LYS B 2 112 ? 13.20149  -6.19163  -3.82530  1.000 45.80495  ? 444 LYS B CB  1 
ATOM   1164 C CG  . LYS B 2 112 ? 12.75990  -7.42361  -3.04584  1.000 56.43335  ? 444 LYS B CG  1 
ATOM   1165 C CD  . LYS B 2 112 ? 13.18787  -8.70167  -3.74781  1.000 65.91381  ? 444 LYS B CD  1 
ATOM   1166 C CE  . LYS B 2 112 ? 12.56434  -9.92894  -3.10119  1.000 67.20719  ? 444 LYS B CE  1 
ATOM   1167 N NZ  . LYS B 2 112 ? 12.82346  -11.15939 -3.90494  1.000 67.90491  ? 444 LYS B NZ  1 
ATOM   1168 N N   . VAL B 2 113 ? 15.67205  -5.09511  -5.74234  1.000 42.76744  ? 445 VAL B N   1 
ATOM   1169 C CA  . VAL B 2 113 ? 15.88122  -4.14168  -6.82273  1.000 35.32681  ? 445 VAL B CA  1 
ATOM   1170 C C   . VAL B 2 113 ? 14.52713  -3.61489  -7.27501  1.000 38.52963  ? 445 VAL B C   1 
ATOM   1171 O O   . VAL B 2 113 ? 13.58111  -4.38217  -7.49759  1.000 38.24498  ? 445 VAL B O   1 
ATOM   1172 C CB  . VAL B 2 113 ? 16.65905  -4.79444  -7.97459  1.000 43.12498  ? 445 VAL B CB  1 
ATOM   1173 C CG1 . VAL B 2 113 ? 16.80909  -3.81793  -9.13356  1.000 39.48563  ? 445 VAL B CG1 1 
ATOM   1174 C CG2 . VAL B 2 113 ? 18.02478  -5.26079  -7.48514  1.000 37.66772  ? 445 VAL B CG2 1 
ATOM   1175 N N   . GLY B 2 114 ? 14.41973  -2.29500  -7.39035  1.000 37.76885  ? 446 GLY B N   1 
ATOM   1176 C CA  . GLY B 2 114 ? 13.14847  -1.65749  -7.63808  1.000 41.63958  ? 446 GLY B CA  1 
ATOM   1177 C C   . GLY B 2 114 ? 12.35495  -1.33197  -6.38859  1.000 42.15656  ? 446 GLY B C   1 
ATOM   1178 O O   . GLY B 2 114 ? 11.35811  -0.60206  -6.47988  1.000 37.14708  ? 446 GLY B O   1 
ATOM   1179 N N   . GLY B 2 115 ? 12.75534  -1.85507  -5.22880  1.000 39.31877  ? 447 GLY B N   1 
ATOM   1180 C CA  . GLY B 2 115 ? 12.08904  -1.53151  -3.98577  1.000 35.10604  ? 447 GLY B CA  1 
ATOM   1181 C C   . GLY B 2 115 ? 11.20055  -2.63875  -3.45791  1.000 42.24715  ? 447 GLY B C   1 
ATOM   1182 O O   . GLY B 2 115 ? 10.37545  -3.19632  -4.18936  1.000 33.90075  ? 447 GLY B O   1 
ATOM   1183 N N   . ASN B 2 116 ? 11.36703  -2.97040  -2.17898  1.000 40.84827  ? 448 ASN B N   1 
ATOM   1184 C CA  . ASN B 2 116 ? 10.48608  -3.90478  -1.48396  1.000 40.05845  ? 448 ASN B CA  1 
ATOM   1185 C C   . ASN B 2 116 ? 9.46045   -3.06984  -0.72873  1.000 41.57990  ? 448 ASN B C   1 
ATOM   1186 O O   . ASN B 2 116 ? 9.77498   -2.46043  0.29699   1.000 42.26521  ? 448 ASN B O   1 
ATOM   1187 C CB  . ASN B 2 116 ? 11.27708  -4.80864  -0.54426  1.000 41.90804  ? 448 ASN B CB  1 
ATOM   1188 C CG  . ASN B 2 116 ? 10.39248  -5.79633  0.19821   1.000 43.66565  ? 448 ASN B CG  1 
ATOM   1189 O OD1 . ASN B 2 116 ? 9.20643   -5.93830  -0.10517  1.000 44.09283  ? 448 ASN B OD1 1 
ATOM   1190 N ND2 . ASN B 2 116 ? 10.97119  -6.49453  1.16903   1.000 41.22474  ? 448 ASN B ND2 1 
ATOM   1191 N N   . TYR B 2 117 ? 8.22737   -3.04369  -1.23218  1.000 39.79922  ? 449 TYR B N   1 
ATOM   1192 C CA  . TYR B 2 117 ? 7.18691   -2.20385  -0.65506  1.000 39.24027  ? 449 TYR B CA  1 
ATOM   1193 C C   . TYR B 2 117 ? 6.29437   -2.95549  0.32301   1.000 37.30182  ? 449 TYR B C   1 
ATOM   1194 O O   . TYR B 2 117 ? 5.25829   -2.42538  0.73591   1.000 47.62907  ? 449 TYR B O   1 
ATOM   1195 C CB  . TYR B 2 117 ? 6.35443   -1.55885  -1.76127  1.000 35.53189  ? 449 TYR B CB  1 
ATOM   1196 C CG  . TYR B 2 117 ? 7.13845   -0.50864  -2.49732  1.000 39.61888  ? 449 TYR B CG  1 
ATOM   1197 C CD1 . TYR B 2 117 ? 7.25462   0.77603   -1.98689  1.000 34.40660  ? 449 TYR B CD1 1 
ATOM   1198 C CD2 . TYR B 2 117 ? 7.78748   -0.80600  -3.69365  1.000 38.90037  ? 449 TYR B CD2 1 
ATOM   1199 C CE1 . TYR B 2 117 ? 7.98257   1.74551   -2.64963  1.000 36.57987  ? 449 TYR B CE1 1 
ATOM   1200 C CE2 . TYR B 2 117 ? 8.51580   0.15517   -4.36399  1.000 33.69881  ? 449 TYR B CE2 1 
ATOM   1201 C CZ  . TYR B 2 117 ? 8.61000   1.42838   -3.83563  1.000 39.75471  ? 449 TYR B CZ  1 
ATOM   1202 O OH  . TYR B 2 117 ? 9.33416   2.39350   -4.49235  1.000 45.60727  ? 449 TYR B OH  1 
ATOM   1203 N N   . ASN B 2 118 ? 6.68148   -4.16898  0.71753   1.000 37.05630  ? 450 ASN B N   1 
ATOM   1204 C CA  . ASN B 2 118 ? 5.89161   -4.90005  1.70141   1.000 40.99523  ? 450 ASN B CA  1 
ATOM   1205 C C   . ASN B 2 118 ? 5.99403   -4.25992  3.08342   1.000 43.59198  ? 450 ASN B C   1 
ATOM   1206 O O   . ASN B 2 118 ? 4.98822   -4.14429  3.79234   1.000 43.98718  ? 450 ASN B O   1 
ATOM   1207 C CB  . ASN B 2 118 ? 6.33022   -6.36481  1.74116   1.000 40.77788  ? 450 ASN B CB  1 
ATOM   1208 C CG  . ASN B 2 118 ? 5.84567   -7.08856  2.98931   1.000 50.04900  ? 450 ASN B CG  1 
ATOM   1209 O OD1 . ASN B 2 118 ? 6.62805   -7.36626  3.90071   1.000 48.88750  ? 450 ASN B OD1 1 
ATOM   1210 N ND2 . ASN B 2 118 ? 4.55072   -7.38553  3.04170   1.000 42.63969  ? 450 ASN B ND2 1 
ATOM   1211 N N   . TYR B 2 119 ? 7.18838   -3.81703  3.47393   1.000 38.74230  ? 451 TYR B N   1 
ATOM   1212 C CA  . TYR B 2 119 ? 7.40588   -3.31430  4.82401   1.000 40.12054  ? 451 TYR B CA  1 
ATOM   1213 C C   . TYR B 2 119 ? 6.98494   -1.85407  4.92963   1.000 40.70021  ? 451 TYR B C   1 
ATOM   1214 O O   . TYR B 2 119 ? 7.42384   -1.01100  4.13968   1.000 38.15019  ? 451 TYR B O   1 
ATOM   1215 C CB  . TYR B 2 119 ? 8.87136   -3.47597  5.22380   1.000 37.22469  ? 451 TYR B CB  1 
ATOM   1216 C CG  . TYR B 2 119 ? 9.31021   -4.91777  5.34492   1.000 42.74779  ? 451 TYR B CG  1 
ATOM   1217 C CD1 . TYR B 2 119 ? 8.86841   -5.71305  6.39544   1.000 41.81877  ? 451 TYR B CD1 1 
ATOM   1218 C CD2 . TYR B 2 119 ? 10.16829  -5.48376  4.41022   1.000 42.18827  ? 451 TYR B CD2 1 
ATOM   1219 C CE1 . TYR B 2 119 ? 9.27028   -7.03488  6.51155   1.000 43.40191  ? 451 TYR B CE1 1 
ATOM   1220 C CE2 . TYR B 2 119 ? 10.57725  -6.80027  4.51933   1.000 41.59589  ? 451 TYR B CE2 1 
ATOM   1221 C CZ  . TYR B 2 119 ? 10.12653  -7.57077  5.57229   1.000 41.45316  ? 451 TYR B CZ  1 
ATOM   1222 O OH  . TYR B 2 119 ? 10.52900  -8.88280  5.68085   1.000 43.57550  ? 451 TYR B OH  1 
ATOM   1223 N N   . ARG B 2 120 ? 6.13521   -1.55967  5.91229   1.000 33.04114  ? 452 ARG B N   1 
ATOM   1224 C CA  . ARG B 2 120 ? 5.62826   -0.21736  6.14221   1.000 34.42062  ? 452 ARG B CA  1 
ATOM   1225 C C   . ARG B 2 120 ? 5.78451   0.15922   7.60972   1.000 34.35770  ? 452 ARG B C   1 
ATOM   1226 O O   . ARG B 2 120 ? 5.97574   -0.69251  8.48100   1.000 35.70699  ? 452 ARG B O   1 
ATOM   1227 C CB  . ARG B 2 120 ? 4.15754   -0.09684  5.72407   1.000 40.02095  ? 452 ARG B CB  1 
ATOM   1228 C CG  . ARG B 2 120 ? 3.91340   -0.22827  4.22425   1.000 39.02194  ? 452 ARG B CG  1 
ATOM   1229 C CD  . ARG B 2 120 ? 2.43227   -0.11054  3.90340   1.000 36.02566  ? 452 ARG B CD  1 
ATOM   1230 N NE  . ARG B 2 120 ? 1.66977   -1.22065  4.46513   1.000 42.03196  ? 452 ARG B NE  1 
ATOM   1231 C CZ  . ARG B 2 120 ? 0.36025   -1.37762  4.32743   1.000 43.28050  ? 452 ARG B CZ  1 
ATOM   1232 N NH1 . ARG B 2 120 ? -0.37552  -0.49131  3.67395   1.000 40.50671  ? 452 ARG B NH1 1 
ATOM   1233 N NH2 . ARG B 2 120 ? -0.22380  -2.45339  4.85375   1.000 40.21534  ? 452 ARG B NH2 1 
ATOM   1234 N N   . TYR B 2 121 ? 5.68378   1.46189   7.86983   1.000 35.06567  ? 453 TYR B N   1 
ATOM   1235 C CA  . TYR B 2 121 ? 5.68496   2.01772   9.21583   1.000 36.39580  ? 453 TYR B CA  1 
ATOM   1236 C C   . TYR B 2 121 ? 4.64719   3.12832   9.27184   1.000 40.40045  ? 453 TYR B C   1 
ATOM   1237 O O   . TYR B 2 121 ? 4.30612   3.73872   8.25283   1.000 32.87378  ? 453 TYR B O   1 
ATOM   1238 C CB  . TYR B 2 121 ? 7.06357   2.57396   9.61320   1.000 33.24414  ? 453 TYR B CB  1 
ATOM   1239 C CG  . TYR B 2 121 ? 7.51217   3.70365   8.70820   1.000 40.51103  ? 453 TYR B CG  1 
ATOM   1240 C CD1 . TYR B 2 121 ? 8.11169   3.44066   7.48284   1.000 40.41526  ? 453 TYR B CD1 1 
ATOM   1241 C CD2 . TYR B 2 121 ? 7.31650   5.03173   9.06912   1.000 37.34843  ? 453 TYR B CD2 1 
ATOM   1242 C CE1 . TYR B 2 121 ? 8.50794   4.46324   6.64852   1.000 37.54390  ? 453 TYR B CE1 1 
ATOM   1243 C CE2 . TYR B 2 121 ? 7.71437   6.06004   8.23925   1.000 37.33649  ? 453 TYR B CE2 1 
ATOM   1244 C CZ  . TYR B 2 121 ? 8.30642   5.76596   7.03293   1.000 38.39843  ? 453 TYR B CZ  1 
ATOM   1245 O OH  . TYR B 2 121 ? 8.70500   6.77286   6.19672   1.000 42.67757  ? 453 TYR B OH  1 
ATOM   1246 N N   . ARG B 2 122 ? 4.15347   3.39339   10.47881  1.000 31.68030  ? 454 ARG B N   1 
ATOM   1247 C CA  . ARG B 2 122 ? 3.17811   4.45584   10.67904  1.000 32.10042  ? 454 ARG B CA  1 
ATOM   1248 C C   . ARG B 2 122 ? 3.89278   5.79569   10.81458  1.000 36.03813  ? 454 ARG B C   1 
ATOM   1249 O O   . ARG B 2 122 ? 4.83066   5.93080   11.60540  1.000 31.01673  ? 454 ARG B O   1 
ATOM   1250 C CB  . ARG B 2 122 ? 2.32476   4.17228   11.91798  1.000 28.53810  ? 454 ARG B CB  1 
ATOM   1251 C CG  . ARG B 2 122 ? 1.17418   5.15479   12.13291  1.000 32.62790  ? 454 ARG B CG  1 
ATOM   1252 C CD  . ARG B 2 122 ? 0.24103   4.70041   13.25835  1.000 33.10095  ? 454 ARG B CD  1 
ATOM   1253 N NE  . ARG B 2 122 ? -0.29041  3.36602   13.00514  1.000 33.65328  ? 454 ARG B NE  1 
ATOM   1254 C CZ  . ARG B 2 122 ? -1.35924  3.11123   12.26321  1.000 36.83418  ? 454 ARG B CZ  1 
ATOM   1255 N NH1 . ARG B 2 122 ? -2.05846  4.08565   11.70056  1.000 28.76984  ? 454 ARG B NH1 1 
ATOM   1256 N NH2 . ARG B 2 122 ? -1.73418  1.84766   12.08099  1.000 31.82203  ? 454 ARG B NH2 1 
ATOM   1257 N N   . LEU B 2 123 ? 3.44649   6.78747   10.04084  1.000 34.86367  ? 455 LEU B N   1 
ATOM   1258 C CA  . LEU B 2 123 ? 4.06010   8.10882   10.04788  1.000 33.83959  ? 455 LEU B CA  1 
ATOM   1259 C C   . LEU B 2 123 ? 3.22503   9.15217   10.77676  1.000 33.15307  ? 455 LEU B C   1 
ATOM   1260 O O   . LEU B 2 123 ? 3.78000   10.15166  11.24617  1.000 31.93189  ? 455 LEU B O   1 
ATOM   1261 C CB  . LEU B 2 123 ? 4.31919   8.57177   8.60305   1.000 34.10852  ? 455 LEU B CB  1 
ATOM   1262 C CG  . LEU B 2 123 ? 5.01118   9.91140   8.34066   1.000 33.66751  ? 455 LEU B CG  1 
ATOM   1263 C CD1 . LEU B 2 123 ? 6.33051   10.01190  9.09425   1.000 30.72830  ? 455 LEU B CD1 1 
ATOM   1264 C CD2 . LEU B 2 123 ? 5.23793   10.09917  6.84049   1.000 35.99225  ? 455 LEU B CD2 1 
ATOM   1265 N N   . PHE B 2 124 ? 1.91884   8.94242   10.89581  1.000 32.82135  ? 456 PHE B N   1 
ATOM   1266 C CA  . PHE B 2 124 ? 1.03105   9.88863   11.55246  1.000 33.98954  ? 456 PHE B CA  1 
ATOM   1267 C C   . PHE B 2 124 ? 0.24396   9.16368   12.63243  1.000 36.44309  ? 456 PHE B C   1 
ATOM   1268 O O   . PHE B 2 124 ? -0.19187  8.02568   12.43276  1.000 37.29690  ? 456 PHE B O   1 
ATOM   1269 C CB  . PHE B 2 124 ? 0.06625   10.53946  10.54785  1.000 33.83489  ? 456 PHE B CB  1 
ATOM   1270 C CG  . PHE B 2 124 ? 0.74263   11.09783  9.31829   1.000 32.17098  ? 456 PHE B CG  1 
ATOM   1271 C CD1 . PHE B 2 124 ? 0.98413   10.29326  8.21674   1.000 30.00375  ? 456 PHE B CD1 1 
ATOM   1272 C CD2 . PHE B 2 124 ? 1.12256   12.43216  9.26280   1.000 32.33395  ? 456 PHE B CD2 1 
ATOM   1273 C CE1 . PHE B 2 124 ? 1.60088   10.80382  7.08293   1.000 34.23859  ? 456 PHE B CE1 1 
ATOM   1274 C CE2 . PHE B 2 124 ? 1.73973   12.94997  8.13404   1.000 33.49162  ? 456 PHE B CE2 1 
ATOM   1275 C CZ  . PHE B 2 124 ? 1.97786   12.13113  7.03961   1.000 31.23699  ? 456 PHE B CZ  1 
ATOM   1276 N N   . ARG B 2 125 ? 0.06808   9.82276   13.77609  1.000 37.57883  ? 457 ARG B N   1 
ATOM   1277 C CA  . ARG B 2 125 ? -0.78210  9.29692   14.83636  1.000 36.60482  ? 457 ARG B CA  1 
ATOM   1278 C C   . ARG B 2 125 ? -1.14898  10.43762  15.77296  1.000 38.82945  ? 457 ARG B C   1 
ATOM   1279 O O   . ARG B 2 125 ? -0.34216  11.34081  16.00288  1.000 37.83353  ? 457 ARG B O   1 
ATOM   1280 C CB  . ARG B 2 125 ? -0.09806  8.16711   15.61355  1.000 33.51133  ? 457 ARG B CB  1 
ATOM   1281 C CG  . ARG B 2 125 ? -1.06601  7.27563   16.34710  1.000 32.01477  ? 457 ARG B CG  1 
ATOM   1282 C CD  . ARG B 2 125 ? -0.38126  6.04528   16.91509  1.000 32.21505  ? 457 ARG B CD  1 
ATOM   1283 N NE  . ARG B 2 125 ? -1.35682  5.08115   17.40941  1.000 38.58077  ? 457 ARG B NE  1 
ATOM   1284 C CZ  . ARG B 2 125 ? -1.81916  5.04441   18.65148  1.000 39.58589  ? 457 ARG B CZ  1 
ATOM   1285 N NH1 . ARG B 2 125 ? -1.39985  5.89901   19.57221  1.000 34.09782  ? 457 ARG B NH1 1 
ATOM   1286 N NH2 . ARG B 2 125 ? -2.71637  4.11991   18.97997  1.000 33.42132  ? 457 ARG B NH2 1 
ATOM   1287 N N   . LYS B 2 126 ? -2.37038  10.38933  16.30369  1.000 38.51084  ? 458 LYS B N   1 
ATOM   1288 C CA  . LYS B 2 126 ? -2.88816  11.46599  17.13562  1.000 39.33870  ? 458 LYS B CA  1 
ATOM   1289 C C   . LYS B 2 126 ? -2.33778  11.43731  18.55334  1.000 44.47697  ? 458 LYS B C   1 
ATOM   1290 O O   . LYS B 2 126 ? -2.46442  12.43548  19.27039  1.000 51.99974  ? 458 LYS B O   1 
ATOM   1291 C CB  . LYS B 2 126 ? -4.41758  11.40709  17.15658  1.000 41.39429  ? 458 LYS B CB  1 
ATOM   1292 C CG  . LYS B 2 126 ? -5.04029  11.82586  15.82856  1.000 61.27490  ? 458 LYS B CG  1 
ATOM   1293 C CD  . LYS B 2 126 ? -6.31054  11.05084  15.50297  1.000 69.40668  ? 458 LYS B CD  1 
ATOM   1294 C CE  . LYS B 2 126 ? -7.48194  11.47477  16.37566  1.000 67.71140  ? 458 LYS B CE  1 
ATOM   1295 N NZ  . LYS B 2 126 ? -8.73277  10.76482  15.97302  1.000 67.91709  ? 458 LYS B NZ  1 
ATOM   1296 N N   . SER B 2 127 ? -1.73663  10.32893  18.97035  1.000 33.62902  ? 459 SER B N   1 
ATOM   1297 C CA  . SER B 2 127 ? -1.06592  10.26041  20.25875  1.000 40.40234  ? 459 SER B CA  1 
ATOM   1298 C C   . SER B 2 127 ? -0.00955  9.17105   20.18775  1.000 36.39264  ? 459 SER B C   1 
ATOM   1299 O O   . SER B 2 127 ? -0.04329  8.30445   19.30947  1.000 35.44928  ? 459 SER B O   1 
ATOM   1300 C CB  . SER B 2 127 ? -2.04819  9.98342   21.40224  1.000 43.28161  ? 459 SER B CB  1 
ATOM   1301 O OG  . SER B 2 127 ? -2.47049  8.63219   21.39529  1.000 44.08047  ? 459 SER B OG  1 
ATOM   1302 N N   . ASN B 2 128 ? 0.93322   9.23383   21.12230  1.000 37.01786  ? 460 ASN B N   1 
ATOM   1303 C CA  . ASN B 2 128 ? 1.96875   8.22053   21.21959  1.000 33.34494  ? 460 ASN B CA  1 
ATOM   1304 C C   . ASN B 2 128 ? 1.36738   6.88561   21.64352  1.000 34.71917  ? 460 ASN B C   1 
ATOM   1305 O O   . ASN B 2 128 ? 0.29043   6.81837   22.24325  1.000 36.18448  ? 460 ASN B O   1 
ATOM   1306 C CB  . ASN B 2 128 ? 3.04553   8.64897   22.21560  1.000 33.72265  ? 460 ASN B CB  1 
ATOM   1307 C CG  . ASN B 2 128 ? 3.79823   9.87887   21.76088  1.000 39.72592  ? 460 ASN B CG  1 
ATOM   1308 O OD1 . ASN B 2 128 ? 4.03060   10.06669  20.56679  1.000 39.73784  ? 460 ASN B OD1 1 
ATOM   1309 N ND2 . ASN B 2 128 ? 4.18049   10.72981  22.71034  1.000 33.15377  ? 460 ASN B ND2 1 
ATOM   1310 N N   . LEU B 2 129 ? 2.07505   5.81006   21.30849  1.000 35.09933  ? 461 LEU B N   1 
ATOM   1311 C CA  . LEU B 2 129 ? 1.67808   4.48066   21.74825  1.000 37.36726  ? 461 LEU B CA  1 
ATOM   1312 C C   . LEU B 2 129 ? 2.03645   4.27517   23.21471  1.000 39.47887  ? 461 LEU B C   1 
ATOM   1313 O O   . LEU B 2 129 ? 3.05804   4.77189   23.69816  1.000 33.32756  ? 461 LEU B O   1 
ATOM   1314 C CB  . LEU B 2 129 ? 2.35621   3.40025   20.90371  1.000 35.08083  ? 461 LEU B CB  1 
ATOM   1315 C CG  . LEU B 2 129 ? 1.85510   3.14123   19.48336  1.000 36.10718  ? 461 LEU B CG  1 
ATOM   1316 C CD1 . LEU B 2 129 ? 2.74296   2.11310   18.81909  1.000 34.86651  ? 461 LEU B CD1 1 
ATOM   1317 C CD2 . LEU B 2 129 ? 0.41979   2.65290   19.50887  1.000 35.18893  ? 461 LEU B CD2 1 
ATOM   1318 N N   . LYS B 2 130 ? 1.18118   3.54653   23.92190  1.000 37.38567  ? 462 LYS B N   1 
ATOM   1319 C CA  . LYS B 2 130 ? 1.55255   3.01993   25.21773  1.000 36.96071  ? 462 LYS B CA  1 
ATOM   1320 C C   . LYS B 2 130 ? 2.51421   1.85191   25.01843  1.000 41.15430  ? 462 LYS B C   1 
ATOM   1321 O O   . LYS B 2 130 ? 2.59394   1.28731   23.92350  1.000 38.94099  ? 462 LYS B O   1 
ATOM   1322 C CB  . LYS B 2 130 ? 0.31142   2.56671   25.97884  1.000 33.96402  ? 462 LYS B CB  1 
ATOM   1323 C CG  . LYS B 2 130 ? -0.73320  3.64945   26.17664  1.000 38.68792  ? 462 LYS B CG  1 
ATOM   1324 C CD  . LYS B 2 130 ? -2.04426  3.04638   26.64266  1.000 38.26614  ? 462 LYS B CD  1 
ATOM   1325 C CE  . LYS B 2 130 ? -3.06878  4.11816   26.95053  1.000 40.32776  ? 462 LYS B CE  1 
ATOM   1326 N NZ  . LYS B 2 130 ? -3.32327  4.98274   25.76995  1.000 40.79598  ? 462 LYS B NZ  1 
ATOM   1327 N N   . PRO B 2 131 ? 3.26982   1.48047   26.05206  1.000 41.59612  ? 463 PRO B N   1 
ATOM   1328 C CA  . PRO B 2 131 ? 4.18039   0.33749   25.91034  1.000 35.35760  ? 463 PRO B CA  1 
ATOM   1329 C C   . PRO B 2 131 ? 3.43853   -0.91566  25.46582  1.000 39.75576  ? 463 PRO B C   1 
ATOM   1330 O O   . PRO B 2 131 ? 2.35851   -1.23247  25.96876  1.000 37.42711  ? 463 PRO B O   1 
ATOM   1331 C CB  . PRO B 2 131 ? 4.77510   0.18577   27.31343  1.000 42.77580  ? 463 PRO B CB  1 
ATOM   1332 C CG  . PRO B 2 131 ? 4.74400   1.57746   27.86741  1.000 39.51634  ? 463 PRO B CG  1 
ATOM   1333 C CD  . PRO B 2 131 ? 3.47123   2.18656   27.33323  1.000 39.51565  ? 463 PRO B CD  1 
ATOM   1334 N N   . PHE B 2 132 ? 4.01872   -1.60434  24.48049  1.000 39.68358  ? 464 PHE B N   1 
ATOM   1335 C CA  . PHE B 2 132 ? 3.50246   -2.85368  23.91935  1.000 35.74171  ? 464 PHE B CA  1 
ATOM   1336 C C   . PHE B 2 132 ? 2.12741   -2.69590  23.27443  1.000 32.35724  ? 464 PHE B C   1 
ATOM   1337 O O   . PHE B 2 132 ? 1.44592   -3.69056  23.01791  1.000 36.13423  ? 464 PHE B O   1 
ATOM   1338 C CB  . PHE B 2 132 ? 3.46785   -3.97009  24.96939  1.000 37.64800  ? 464 PHE B CB  1 
ATOM   1339 C CG  . PHE B 2 132 ? 4.81985   -4.31454  25.52776  1.000 42.21950  ? 464 PHE B CG  1 
ATOM   1340 C CD1 . PHE B 2 132 ? 5.78514   -4.90464  24.72510  1.000 44.85601  ? 464 PHE B CD1 1 
ATOM   1341 C CD2 . PHE B 2 132 ? 5.12422   -4.05260  26.85409  1.000 39.90259  ? 464 PHE B CD2 1 
ATOM   1342 C CE1 . PHE B 2 132 ? 7.03070   -5.22273  25.23373  1.000 45.25924  ? 464 PHE B CE1 1 
ATOM   1343 C CE2 . PHE B 2 132 ? 6.36556   -4.36776  27.36896  1.000 38.81789  ? 464 PHE B CE2 1 
ATOM   1344 C CZ  . PHE B 2 132 ? 7.32190   -4.95066  26.55941  1.000 45.39915  ? 464 PHE B CZ  1 
ATOM   1345 N N   . GLU B 2 133 ? 1.70141   -1.46811  22.99506  1.000 35.19158  ? 465 GLU B N   1 
ATOM   1346 C CA  . GLU B 2 133 ? 0.50324   -1.24811  22.19622  1.000 36.33552  ? 465 GLU B CA  1 
ATOM   1347 C C   . GLU B 2 133 ? 0.80191   -1.52302  20.72162  1.000 37.67151  ? 465 GLU B C   1 
ATOM   1348 O O   . GLU B 2 133 ? 1.92836   -1.34414  20.25094  1.000 38.76193  ? 465 GLU B O   1 
ATOM   1349 C CB  . GLU B 2 133 ? -0.00859  0.18579   22.37999  1.000 32.14106  ? 465 GLU B CB  1 
ATOM   1350 C CG  . GLU B 2 133 ? -1.44383  0.41692   21.90910  1.000 39.66972  ? 465 GLU B CG  1 
ATOM   1351 C CD  . GLU B 2 133 ? -1.96417  1.81582   22.23740  1.000 39.92565  ? 465 GLU B CD  1 
ATOM   1352 O OE1 . GLU B 2 133 ? -1.22087  2.60526   22.85153  1.000 36.78597  ? 465 GLU B OE1 1 
ATOM   1353 O OE2 . GLU B 2 133 ? -3.11883  2.13463   21.88104  1.000 47.54375  ? 465 GLU B OE2 1 
ATOM   1354 N N   . ARG B 2 134 ? -0.21286  -1.99146  19.99713  1.000 38.56961  ? 466 ARG B N   1 
ATOM   1355 C CA  . ARG B 2 134 ? -0.11841  -2.23107  18.56148  1.000 36.88092  ? 466 ARG B CA  1 
ATOM   1356 C C   . ARG B 2 134 ? -1.28510  -1.54707  17.86779  1.000 40.02871  ? 466 ARG B C   1 
ATOM   1357 O O   . ARG B 2 134 ? -2.43231  -1.68607  18.30140  1.000 41.53978  ? 466 ARG B O   1 
ATOM   1358 C CB  . ARG B 2 134 ? -0.12659  -3.72502  18.21814  1.000 37.35880  ? 466 ARG B CB  1 
ATOM   1359 C CG  . ARG B 2 134 ? -0.03470  -3.98536  16.70940  1.000 40.94355  ? 466 ARG B CG  1 
ATOM   1360 C CD  . ARG B 2 134 ? -0.39016  -5.41279  16.30755  1.000 42.95413  ? 466 ARG B CD  1 
ATOM   1361 N NE  . ARG B 2 134 ? 0.60635   -6.37465  16.75926  1.000 51.02281  ? 466 ARG B NE  1 
ATOM   1362 C CZ  . ARG B 2 134 ? 0.50795   -7.08592  17.87431  1.000 57.35293  ? 466 ARG B CZ  1 
ATOM   1363 N NH1 . ARG B 2 134 ? -0.54592  -6.98325  18.66737  1.000 55.38882  ? 466 ARG B NH1 1 
ATOM   1364 N NH2 . ARG B 2 134 ? 1.49131   -7.92200  18.20081  1.000 58.52703  ? 466 ARG B NH2 1 
ATOM   1365 N N   . ASP B 2 135 ? -0.99372  -0.82699  16.78326  1.000 40.58254  ? 467 ASP B N   1 
ATOM   1366 C CA  . ASP B 2 135 ? -2.00397  -0.10472  16.01385  1.000 35.69504  ? 467 ASP B CA  1 
ATOM   1367 C C   . ASP B 2 135 ? -1.87633  -0.50829  14.54987  1.000 41.85993  ? 467 ASP B C   1 
ATOM   1368 O O   . ASP B 2 135 ? -0.87790  -0.18740  13.89601  1.000 40.12813  ? 467 ASP B O   1 
ATOM   1369 C CB  . ASP B 2 135 ? -1.84262  1.40638   16.18732  1.000 35.33786  ? 467 ASP B CB  1 
ATOM   1370 C CG  . ASP B 2 135 ? -2.89812  2.20417   15.44130  1.000 39.05488  ? 467 ASP B CG  1 
ATOM   1371 O OD1 . ASP B 2 135 ? -3.71539  1.60832   14.70606  1.000 41.15772  ? 467 ASP B OD1 1 
ATOM   1372 O OD2 . ASP B 2 135 ? -2.91153  3.44177   15.59763  1.000 37.09804  ? 467 ASP B OD2 1 
ATOM   1373 N N   . ILE B 2 136 ? -2.89568  -1.19203  14.03012  1.000 43.98555  ? 468 ILE B N   1 
ATOM   1374 C CA  . ILE B 2 136 ? -2.91711  -1.63107  12.64351  1.000 40.18169  ? 468 ILE B CA  1 
ATOM   1375 C C   . ILE B 2 136 ? -4.02148  -0.95266  11.84491  1.000 40.82602  ? 468 ILE B C   1 
ATOM   1376 O O   . ILE B 2 136 ? -4.35160  -1.40444  10.75188  1.000 44.58196  ? 468 ILE B O   1 
ATOM   1377 C CB  . ILE B 2 136 ? -3.03704  -3.16474  12.54292  1.000 40.80402  ? 468 ILE B CB  1 
ATOM   1378 C CG1 . ILE B 2 136 ? -4.37372  -3.63786  13.11628  1.000 45.65033  ? 468 ILE B CG1 1 
ATOM   1379 C CG2 . ILE B 2 136 ? -1.87584  -3.83918  13.25932  1.000 39.91482  ? 468 ILE B CG2 1 
ATOM   1380 C CD1 . ILE B 2 136 ? -4.58507  -5.13532  13.00775  1.000 48.86416  ? 468 ILE B CD1 1 
ATOM   1381 N N   . SER B 2 137 ? -4.59918  0.12670   12.36728  1.000 40.64879  ? 469 SER B N   1 
ATOM   1382 C CA  . SER B 2 137 ? -5.62845  0.84911   11.63387  1.000 36.53447  ? 469 SER B CA  1 
ATOM   1383 C C   . SER B 2 137 ? -5.03242  1.56029   10.42139  1.000 41.64272  ? 469 SER B C   1 
ATOM   1384 O O   . SER B 2 137 ? -3.84130  1.88496   10.38201  1.000 40.50403  ? 469 SER B O   1 
ATOM   1385 C CB  . SER B 2 137 ? -6.32318  1.86171   12.54289  1.000 37.42589  ? 469 SER B CB  1 
ATOM   1386 O OG  . SER B 2 137 ? -5.41755  2.85584   12.98997  1.000 40.02880  ? 469 SER B OG  1 
ATOM   1387 N N   . THR B 2 138 ? -5.87744  1.80038   9.41997   1.000 39.16966  ? 470 THR B N   1 
ATOM   1388 C CA  . THR B 2 138 ? -5.46655  2.48215   8.19769   1.000 37.04445  ? 470 THR B CA  1 
ATOM   1389 C C   . THR B 2 138 ? -6.42803  3.61036   7.86482   1.000 43.11827  ? 470 THR B C   1 
ATOM   1390 O O   . THR B 2 138 ? -6.73617  3.86899   6.69846   1.000 45.10727  ? 470 THR B O   1 
ATOM   1391 C CB  . THR B 2 138 ? -5.35871  1.51005   7.02628   1.000 37.91414  ? 470 THR B CB  1 
ATOM   1392 O OG1 . THR B 2 138 ? -6.59292  0.80115   6.88207   1.000 43.19044  ? 470 THR B OG1 1 
ATOM   1393 C CG2 . THR B 2 138 ? -4.22733  0.51606   7.25280   1.000 37.82477  ? 470 THR B CG2 1 
ATOM   1394 N N   . GLU B 2 139 ? -6.91419  4.30352   8.88781   1.000 38.15431  ? 471 GLU B N   1 
ATOM   1395 C CA  . GLU B 2 139 ? -7.77849  5.45106   8.66465   1.000 43.99644  ? 471 GLU B CA  1 
ATOM   1396 C C   . GLU B 2 139 ? -6.95845  6.62510   8.14601   1.000 39.84640  ? 471 GLU B C   1 
ATOM   1397 O O   . GLU B 2 139 ? -5.81895  6.83884   8.56825   1.000 40.94070  ? 471 GLU B O   1 
ATOM   1398 C CB  . GLU B 2 139 ? -8.49558  5.82724   9.96381   1.000 44.52112  ? 471 GLU B CB  1 
ATOM   1399 C CG  . GLU B 2 139 ? -9.35158  7.08463   9.88028   1.000 57.52741  ? 471 GLU B CG  1 
ATOM   1400 C CD  . GLU B 2 139 ? -10.16527 7.32481   11.14371  1.000 76.66449  ? 471 GLU B CD  1 
ATOM   1401 O OE1 . GLU B 2 139 ? -10.59153 6.33167   11.77271  1.000 84.84599  ? 471 GLU B OE1 1 
ATOM   1402 O OE2 . GLU B 2 139 ? -10.37723 8.50430   11.50721  1.000 78.14248  ? 471 GLU B OE2 1 
ATOM   1403 N N   . ILE B 2 140 ? -7.54351  7.38975   7.22404   1.000 36.92977  ? 472 ILE B N   1 
ATOM   1404 C CA  . ILE B 2 140 ? -6.84074  8.53309   6.65215   1.000 38.04860  ? 472 ILE B CA  1 
ATOM   1405 C C   . ILE B 2 140 ? -6.63443  9.57842   7.73818   1.000 43.19958  ? 472 ILE B C   1 
ATOM   1406 O O   . ILE B 2 140 ? -7.58734  9.99285   8.40896   1.000 43.36612  ? 472 ILE B O   1 
ATOM   1407 C CB  . ILE B 2 140 ? -7.61525  9.10333   5.46026   1.000 41.87987  ? 472 ILE B CB  1 
ATOM   1408 C CG1 . ILE B 2 140 ? -7.82424  8.02822   4.39042   1.000 44.75629  ? 472 ILE B CG1 1 
ATOM   1409 C CG2 . ILE B 2 140 ? -6.88551  10.30013  4.87571   1.000 38.37708  ? 472 ILE B CG2 1 
ATOM   1410 C CD1 . ILE B 2 140 ? -6.55570  7.59375   3.68763   1.000 41.20021  ? 472 ILE B CD1 1 
ATOM   1411 N N   . TYR B 2 141 ? -5.38563  10.00931  7.91786   1.000 39.88695  ? 473 TYR B N   1 
ATOM   1412 C CA  . TYR B 2 141 ? -5.04910  10.97713  8.95455   1.000 40.56830  ? 473 TYR B CA  1 
ATOM   1413 C C   . TYR B 2 141 ? -5.41864  12.37726  8.48060   1.000 44.11897  ? 473 TYR B C   1 
ATOM   1414 O O   . TYR B 2 141 ? -4.90469  12.84915  7.46052   1.000 37.66457  ? 473 TYR B O   1 
ATOM   1415 C CB  . TYR B 2 141 ? -3.56330  10.89862  9.30392   1.000 35.67911  ? 473 TYR B CB  1 
ATOM   1416 C CG  . TYR B 2 141 ? -3.14674  11.81488  10.43721  1.000 38.34319  ? 473 TYR B CG  1 
ATOM   1417 C CD1 . TYR B 2 141 ? -3.21295  11.39205  11.76256  1.000 37.26238  ? 473 TYR B CD1 1 
ATOM   1418 C CD2 . TYR B 2 141 ? -2.67949  13.10038  10.18170  1.000 37.90171  ? 473 TYR B CD2 1 
ATOM   1419 C CE1 . TYR B 2 141 ? -2.82965  12.22679  12.79958  1.000 40.89692  ? 473 TYR B CE1 1 
ATOM   1420 C CE2 . TYR B 2 141 ? -2.29466  13.93911  11.20770  1.000 40.35987  ? 473 TYR B CE2 1 
ATOM   1421 C CZ  . TYR B 2 141 ? -2.37191  13.49922  12.51520  1.000 47.59634  ? 473 TYR B CZ  1 
ATOM   1422 O OH  . TYR B 2 141 ? -1.98868  14.33777  13.53856  1.000 50.79763  ? 473 TYR B OH  1 
ATOM   1423 N N   . GLN B 2 142 ? -6.29301  13.04502  9.23221   1.000 38.49308  ? 474 GLN B N   1 
ATOM   1424 C CA  . GLN B 2 142 ? -6.78114  14.37706  8.88285   1.000 40.24950  ? 474 GLN B CA  1 
ATOM   1425 C C   . GLN B 2 142 ? -5.86986  15.41630  9.52923   1.000 39.73085  ? 474 GLN B C   1 
ATOM   1426 O O   . GLN B 2 142 ? -5.99864  15.72154  10.71686  1.000 42.22339  ? 474 GLN B O   1 
ATOM   1427 C CB  . GLN B 2 142 ? -8.22960  14.54750  9.32540   1.000 36.77894  ? 474 GLN B CB  1 
ATOM   1428 C CG  . GLN B 2 142 ? -8.79447  15.91632  9.01918   1.000 40.52366  ? 474 GLN B CG  1 
ATOM   1429 C CD  . GLN B 2 142 ? -10.09213 16.17926  9.74788   1.000 45.16681  ? 474 GLN B CD  1 
ATOM   1430 O OE1 . GLN B 2 142 ? -10.96409 15.31198  9.82140   1.000 45.65641  ? 474 GLN B OE1 1 
ATOM   1431 N NE2 . GLN B 2 142 ? -10.22492 17.37784  10.30180  1.000 41.20944  ? 474 GLN B NE2 1 
ATOM   1432 N N   . ALA B 2 143 ? -4.95602  15.97995  8.73446   1.000 36.26999  ? 475 ALA B N   1 
ATOM   1433 C CA  . ALA B 2 143 ? -3.96710  16.91504  9.25769   1.000 32.43580  ? 475 ALA B CA  1 
ATOM   1434 C C   . ALA B 2 143 ? -4.52040  18.32531  9.39458   1.000 35.63335  ? 475 ALA B C   1 
ATOM   1435 O O   . ALA B 2 143 ? -4.03494  19.09598  10.23025  1.000 38.44101  ? 475 ALA B O   1 
ATOM   1436 C CB  . ALA B 2 143 ? -2.73208  16.92749  8.35732   1.000 37.02936  ? 475 ALA B CB  1 
ATOM   1437 N N   . GLY B 2 144 ? -5.51462  18.68698  8.58749   1.000 40.10905  ? 476 GLY B N   1 
ATOM   1438 C CA  . GLY B 2 144 ? -6.16571  19.97755  8.67881   1.000 41.32362  ? 476 GLY B CA  1 
ATOM   1439 C C   . GLY B 2 144 ? -7.55312  19.88302  9.28659   1.000 45.57226  ? 476 GLY B C   1 
ATOM   1440 O O   . GLY B 2 144 ? -7.90918  18.90427  9.95084   1.000 40.93890  ? 476 GLY B O   1 
ATOM   1441 N N   . ASN B 2 145 ? -8.35410  20.91978  9.04355   1.000 42.72120  ? 477 ASN B N   1 
ATOM   1442 C CA  . ASN B 2 145 ? -9.71126  20.98534  9.56384   1.000 46.23729  ? 477 ASN B CA  1 
ATOM   1443 C C   . ASN B 2 145 ? -10.76557 20.51389  8.57203   1.000 46.13370  ? 477 ASN B C   1 
ATOM   1444 O O   . ASN B 2 145 ? -11.93604 20.39857  8.94754   1.000 46.50177  ? 477 ASN B O   1 
ATOM   1445 C CB  . ASN B 2 145 ? -10.03598 22.41255  10.00205  1.000 45.92621  ? 477 ASN B CB  1 
ATOM   1446 C CG  . ASN B 2 145 ? -9.19181  22.85994  11.17046  1.000 48.80969  ? 477 ASN B CG  1 
ATOM   1447 O OD1 . ASN B 2 145 ? -8.80278  22.05038  12.01384  1.000 52.44906  ? 477 ASN B OD1 1 
ATOM   1448 N ND2 . ASN B 2 145 ? -8.90039  24.15270  11.22973  1.000 50.40676  ? 477 ASN B ND2 1 
ATOM   1449 N N   . LYS B 2 146 ? -10.39163 20.24056  7.33128   1.000 43.10915  ? 478 LYS B N   1 
ATOM   1450 C CA  . LYS B 2 146 ? -11.39818 19.76273  6.39166   1.000 48.23529  ? 478 LYS B CA  1 
ATOM   1451 C C   . LYS B 2 146 ? -11.49396 18.24070  6.45666   1.000 46.39494  ? 478 LYS B C   1 
ATOM   1452 O O   . LYS B 2 146 ? -10.48203 17.56467  6.66616   1.000 41.36335  ? 478 LYS B O   1 
ATOM   1453 C CB  . LYS B 2 146 ? -11.05638 20.20157  4.96802   1.000 46.74654  ? 478 LYS B CB  1 
ATOM   1454 C CG  . LYS B 2 146 ? -10.86595 21.70910  4.83080   1.000 53.75998  ? 478 LYS B CG  1 
ATOM   1455 C CD  . LYS B 2 146 ? -10.49244 22.11733  3.41017   1.000 65.01114  ? 478 LYS B CD  1 
ATOM   1456 C CE  . LYS B 2 146 ? -11.65584 21.94381  2.44746   1.000 64.16704  ? 478 LYS B CE  1 
ATOM   1457 N NZ  . LYS B 2 146 ? -11.30841 22.41197  1.07409   1.000 76.02862  ? 478 LYS B NZ  1 
ATOM   1458 N N   . PRO B 2 147 ? -12.68994 17.67719  6.29984   1.000 48.88679  ? 479 PRO B N   1 
ATOM   1459 C CA  . PRO B 2 147 ? -12.82713 16.21903  6.37495   1.000 47.46033  ? 479 PRO B CA  1 
ATOM   1460 C C   . PRO B 2 147 ? -12.17718 15.53247  5.18433   1.000 47.35085  ? 479 PRO B C   1 
ATOM   1461 O O   . PRO B 2 147 ? -12.03838 16.10276  4.10027   1.000 46.32443  ? 479 PRO B O   1 
ATOM   1462 C CB  . PRO B 2 147 ? -14.34556 16.00416  6.38093   1.000 47.62907  ? 479 PRO B CB  1 
ATOM   1463 C CG  . PRO B 2 147 ? -14.89264 17.21122  5.68825   1.000 53.46977  ? 479 PRO B CG  1 
ATOM   1464 C CD  . PRO B 2 147 ? -13.98663 18.34604  6.08919   1.000 50.82009  ? 479 PRO B CD  1 
ATOM   1465 N N   . CYS B 2 148 ? -11.77669 14.28253  5.39988   1.000 43.51048  ? 480 CYS B N   1 
ATOM   1466 C CA  . CYS B 2 148 ? -11.10858 13.51008  4.36417   1.000 44.71873  ? 480 CYS B CA  1 
ATOM   1467 C C   . CYS B 2 148 ? -12.03542 12.54790  3.63471   1.000 50.50320  ? 480 CYS B C   1 
ATOM   1468 O O   . CYS B 2 148 ? -11.68188 12.08546  2.54409   1.000 46.62263  ? 480 CYS B O   1 
ATOM   1469 C CB  . CYS B 2 148 ? -9.93817  12.72151  4.96799   1.000 51.43461  ? 480 CYS B CB  1 
ATOM   1470 S SG  . CYS B 2 148 ? -8.70230  13.75637  5.82426   1.000 58.19727  ? 480 CYS B SG  1 
ATOM   1471 N N   . ASN B 2 149 ? -13.19058 12.21661  4.21838   1.000 49.67941  ? 481 ASN B N   1 
ATOM   1472 C CA  . ASN B 2 149 ? -14.18318 11.34576  3.58491   1.000 51.82037  ? 481 ASN B CA  1 
ATOM   1473 C C   . ASN B 2 149 ? -13.57949 10.01764  3.14284   1.000 52.57260  ? 481 ASN B C   1 
ATOM   1474 O O   . ASN B 2 149 ? -13.99530 9.44105   2.13547   1.000 53.56670  ? 481 ASN B O   1 
ATOM   1475 C CB  . ASN B 2 149 ? -14.85698 12.04210  2.39876   1.000 46.50693  ? 481 ASN B CB  1 
ATOM   1476 C CG  . ASN B 2 149 ? -15.57712 13.31649  2.80451   1.000 56.24895  ? 481 ASN B CG  1 
ATOM   1477 O OD1 . ASN B 2 149 ? -16.31431 13.34069  3.79310   1.000 59.39692  ? 481 ASN B OD1 1 
ATOM   1478 N ND2 . ASN B 2 149 ? -15.35658 14.38849  2.04782   1.000 60.78385  ? 481 ASN B ND2 1 
ATOM   1479 N N   . GLY B 2 150 ? -12.58372 9.53497   3.88165   1.000 47.33533  ? 482 GLY B N   1 
ATOM   1480 C CA  . GLY B 2 150 ? -11.98091 8.24968   3.60084   1.000 45.48254  ? 482 GLY B CA  1 
ATOM   1481 C C   . GLY B 2 150 ? -11.07088 8.18818   2.39270   1.000 43.28835  ? 482 GLY B C   1 
ATOM   1482 O O   . GLY B 2 150 ? -10.73074 7.08244   1.95897   1.000 49.67719  ? 482 GLY B O   1 
ATOM   1483 N N   . VAL B 2 151 ? -10.65147 9.32305   1.83362   1.000 41.71322  ? 483 VAL B N   1 
ATOM   1484 C CA  . VAL B 2 151 ? -9.76936  9.32532   0.67025   1.000 50.92342  ? 483 VAL B CA  1 
ATOM   1485 C C   . VAL B 2 151 ? -8.58111  10.24201  0.93154   1.000 45.54228  ? 483 VAL B C   1 
ATOM   1486 O O   . VAL B 2 151 ? -8.73953  11.35871  1.43819   1.000 37.77234  ? 483 VAL B O   1 
ATOM   1487 C CB  . VAL B 2 151 ? -10.50866 9.74187   -0.62462  1.000 51.22254  ? 483 VAL B CB  1 
ATOM   1488 C CG1 . VAL B 2 151 ? -11.59481 8.73253   -0.96223  1.000 53.71711  ? 483 VAL B CG1 1 
ATOM   1489 C CG2 . VAL B 2 151 ? -11.09842 11.14142  -0.50280  1.000 45.43763  ? 483 VAL B CG2 1 
ATOM   1490 N N   . ALA B 2 152 ? -7.38889  9.76398   0.58135   1.000 38.79282  ? 484 ALA B N   1 
ATOM   1491 C CA  . ALA B 2 152 ? -6.19036  10.57896  0.69364   1.000 39.54657  ? 484 ALA B CA  1 
ATOM   1492 C C   . ALA B 2 152 ? -6.26622  11.77361  -0.24950  1.000 40.63567  ? 484 ALA B C   1 
ATOM   1493 O O   . ALA B 2 152 ? -6.82365  11.69576  -1.34819  1.000 45.86500  ? 484 ALA B O   1 
ATOM   1494 C CB  . ALA B 2 152 ? -4.94506  9.74911   0.38307   1.000 36.11070  ? 484 ALA B CB  1 
ATOM   1495 N N   . GLY B 2 153 ? -5.70253  12.88854  0.19966   1.000 37.27103  ? 485 GLY B N   1 
ATOM   1496 C CA  . GLY B 2 153 ? -5.67238  14.11083  -0.57385  1.000 38.60206  ? 485 GLY B CA  1 
ATOM   1497 C C   . GLY B 2 153 ? -4.87683  15.17203  0.15491   1.000 39.45373  ? 485 GLY B C   1 
ATOM   1498 O O   . GLY B 2 153 ? -4.03877  14.84783  1.00441   1.000 40.12513  ? 485 GLY B O   1 
ATOM   1499 N N   . VAL B 2 154 ? -5.13692  16.44040  -0.16303  1.000 37.72908  ? 486 VAL B N   1 
ATOM   1500 C CA  . VAL B 2 154 ? -4.43618  17.54071  0.48673   1.000 37.20970  ? 486 VAL B CA  1 
ATOM   1501 C C   . VAL B 2 154 ? -4.71024  17.49892  1.98388   1.000 39.09555  ? 486 VAL B C   1 
ATOM   1502 O O   . VAL B 2 154 ? -5.86766  17.45578  2.41912   1.000 39.48632  ? 486 VAL B O   1 
ATOM   1503 C CB  . VAL B 2 154 ? -4.85927  18.87844  -0.12410  1.000 37.99504  ? 486 VAL B CB  1 
ATOM   1504 C CG1 . VAL B 2 154 ? -4.22650  20.03507  0.63642   1.000 38.50152  ? 486 VAL B CG1 1 
ATOM   1505 C CG2 . VAL B 2 154 ? -4.47018  18.93135  -1.60244  1.000 42.06905  ? 486 VAL B CG2 1 
ATOM   1506 N N   . ASN B 2 155 ? -3.63968  17.50317  2.78074   1.000 41.45776  ? 487 ASN B N   1 
ATOM   1507 C CA  . ASN B 2 155 ? -3.70799  17.46843  4.24401   1.000 39.45099  ? 487 ASN B CA  1 
ATOM   1508 C C   . ASN B 2 155 ? -4.50694  16.27862  4.76003   1.000 35.02704  ? 487 ASN B C   1 
ATOM   1509 O O   . ASN B 2 155 ? -5.03958  16.32064  5.87013   1.000 37.51660  ? 487 ASN B O   1 
ATOM   1510 C CB  . ASN B 2 155 ? -4.28448  18.76853  4.81472   1.000 40.30622  ? 487 ASN B CB  1 
ATOM   1511 C CG  . ASN B 2 155 ? -3.40181  19.96715  4.53556   1.000 43.80908  ? 487 ASN B CG  1 
ATOM   1512 O OD1 . ASN B 2 155 ? -3.89249  21.05009  4.22498   1.000 47.36654  ? 487 ASN B OD1 1 
ATOM   1513 N ND2 . ASN B 2 155 ? -2.08683  19.77619  4.63694   1.000 42.27598  ? 487 ASN B ND2 1 
ATOM   1514 N N   . CYS B 2 156 ? -4.59382  15.21748  3.96212   1.000 34.81047  ? 488 CYS B N   1 
ATOM   1515 C CA  . CYS B 2 156 ? -5.34301  14.00671  4.28852   1.000 36.03779  ? 488 CYS B CA  1 
ATOM   1516 C C   . CYS B 2 156 ? -4.46224  12.84320  3.85427   1.000 39.22451  ? 488 CYS B C   1 
ATOM   1517 O O   . CYS B 2 156 ? -4.47863  12.45072  2.68371   1.000 37.60037  ? 488 CYS B O   1 
ATOM   1518 C CB  . CYS B 2 156 ? -6.69563  13.97645  3.58157   1.000 41.95597  ? 488 CYS B CB  1 
ATOM   1519 S SG  . CYS B 2 156 ? -7.98426  14.98948  4.35600   1.000 41.15945  ? 488 CYS B SG  1 
ATOM   1520 N N   . TYR B 2 157 ? -3.70237  12.28695  4.79032   1.000 35.78076  ? 489 TYR B N   1 
ATOM   1521 C CA  . TYR B 2 157 ? -2.59268  11.40910  4.45695   1.000 34.76628  ? 489 TYR B CA  1 
ATOM   1522 C C   . TYR B 2 157 ? -2.87686  9.97897   4.88916   1.000 35.39149  ? 489 TYR B C   1 
ATOM   1523 O O   . TYR B 2 157 ? -3.30621  9.73451   6.02170   1.000 36.59201  ? 489 TYR B O   1 
ATOM   1524 C CB  . TYR B 2 157 ? -1.29977  11.91397  5.10796   1.000 33.16966  ? 489 TYR B CB  1 
ATOM   1525 C CG  . TYR B 2 157 ? -1.04051  13.38495  4.84026   1.000 36.19441  ? 489 TYR B CG  1 
ATOM   1526 C CD1 . TYR B 2 157 ? -0.87609  13.85615  3.53736   1.000 33.05519  ? 489 TYR B CD1 1 
ATOM   1527 C CD2 . TYR B 2 157 ? -0.96181  14.30241  5.88443   1.000 32.53111  ? 489 TYR B CD2 1 
ATOM   1528 C CE1 . TYR B 2 157 ? -0.64129  15.19721  3.28402   1.000 28.28233  ? 489 TYR B CE1 1 
ATOM   1529 C CE2 . TYR B 2 157 ? -0.72474  15.64777  5.64030   1.000 35.44096  ? 489 TYR B CE2 1 
ATOM   1530 C CZ  . TYR B 2 157 ? -0.56680  16.08576  4.33395   1.000 33.77214  ? 489 TYR B CZ  1 
ATOM   1531 O OH  . TYR B 2 157 ? -0.33461  17.41639  4.07871   1.000 38.24507  ? 489 TYR B OH  1 
ATOM   1532 N N   . PHE B 2 158 ? -2.63433  9.03890   3.98080   1.000 37.34343  ? 490 PHE B N   1 
ATOM   1533 C CA  . PHE B 2 158 ? -2.62305  7.63637   4.36448   1.000 37.53148  ? 490 PHE B CA  1 
ATOM   1534 C C   . PHE B 2 158 ? -1.59361  7.44232   5.47570   1.000 38.55762  ? 490 PHE B C   1 
ATOM   1535 O O   . PHE B 2 158 ? -0.44801  7.89206   5.33639   1.000 38.77058  ? 490 PHE B O   1 
ATOM   1536 C CB  . PHE B 2 158 ? -2.29669  6.74060   3.17115   1.000 30.09163  ? 490 PHE B CB  1 
ATOM   1537 C CG  . PHE B 2 158 ? -2.53858  5.29050   3.43563   1.000 34.14901  ? 490 PHE B CG  1 
ATOM   1538 C CD1 . PHE B 2 158 ? -3.82453  4.78502   3.41920   1.000 32.24789  ? 490 PHE B CD1 1 
ATOM   1539 C CD2 . PHE B 2 158 ? -1.48741  4.43623   3.72220   1.000 34.20877  ? 490 PHE B CD2 1 
ATOM   1540 C CE1 . PHE B 2 158 ? -4.06028  3.45208   3.67768   1.000 39.69310  ? 490 PHE B CE1 1 
ATOM   1541 C CE2 . PHE B 2 158 ? -1.71474  3.09954   3.98127   1.000 37.25988  ? 490 PHE B CE2 1 
ATOM   1542 C CZ  . PHE B 2 158 ? -3.00642  2.60649   3.95863   1.000 40.13384  ? 490 PHE B CZ  1 
ATOM   1543 N N   . PRO B 2 159 ? -1.95790  6.80199   6.58987   1.000 37.14042  ? 491 PRO B N   1 
ATOM   1544 C CA  . PRO B 2 159 ? -1.10704  6.88076   7.78869   1.000 38.05097  ? 491 PRO B CA  1 
ATOM   1545 C C   . PRO B 2 159 ? 0.16072   6.05386   7.70266   1.000 39.11688  ? 491 PRO B C   1 
ATOM   1546 O O   . PRO B 2 159 ? 1.12177   6.36311   8.41794   1.000 39.21140  ? 491 PRO B O   1 
ATOM   1547 C CB  . PRO B 2 159 ? -2.03027  6.37326   8.90518   1.000 33.62688  ? 491 PRO B CB  1 
ATOM   1548 C CG  . PRO B 2 159 ? -2.96635  5.44335   8.20381   1.000 34.71360  ? 491 PRO B CG  1 
ATOM   1549 C CD  . PRO B 2 159 ? -3.18856  6.02899   6.83041   1.000 37.05127  ? 491 PRO B CD  1 
ATOM   1550 N N   . LEU B 2 160 ? 0.19900   5.02419   6.86223   1.000 35.41466  ? 492 LEU B N   1 
ATOM   1551 C CA  . LEU B 2 160 ? 1.36379   4.16147   6.72658   1.000 36.29540  ? 492 LEU B CA  1 
ATOM   1552 C C   . LEU B 2 160 ? 2.21481   4.61712   5.54833   1.000 43.01488  ? 492 LEU B C   1 
ATOM   1553 O O   . LEU B 2 160 ? 1.69227   5.12523   4.55331   1.000 38.40609  ? 492 LEU B O   1 
ATOM   1554 C CB  . LEU B 2 160 ? 0.94418   2.70214   6.52817   1.000 33.79039  ? 492 LEU B CB  1 
ATOM   1555 C CG  . LEU B 2 160 ? 0.00719   2.12384   7.58832   1.000 36.63929  ? 492 LEU B CG  1 
ATOM   1556 C CD1 . LEU B 2 160 ? -0.27569  0.66283   7.31016   1.000 36.33433  ? 492 LEU B CD1 1 
ATOM   1557 C CD2 . LEU B 2 160 ? 0.60364   2.30793   8.98211   1.000 35.72912  ? 492 LEU B CD2 1 
ATOM   1558 N N   . GLN B 2 161 ? 3.52932   4.44451   5.67572   1.000 40.34772  ? 493 GLN B N   1 
ATOM   1559 C CA  . GLN B 2 161 ? 4.48369   4.70886   4.60846   1.000 39.56018  ? 493 GLN B CA  1 
ATOM   1560 C C   . GLN B 2 161 ? 5.35772   3.48030   4.42813   1.000 42.26874  ? 493 GLN B C   1 
ATOM   1561 O O   . GLN B 2 161 ? 5.68577   2.80126   5.40291   1.000 36.73233  ? 493 GLN B O   1 
ATOM   1562 C CB  . GLN B 2 161 ? 5.37450   5.92622   4.91143   1.000 38.73256  ? 493 GLN B CB  1 
ATOM   1563 C CG  . GLN B 2 161 ? 4.88920   7.23954   4.31918   1.000 52.29383  ? 493 GLN B CG  1 
ATOM   1564 C CD  . GLN B 2 161 ? 4.65375   7.16052   2.81838   1.000 42.35363  ? 493 GLN B CD  1 
ATOM   1565 O OE1 . GLN B 2 161 ? 5.59448   7.05664   2.02564   1.000 46.64674  ? 493 GLN B OE1 1 
ATOM   1566 N NE2 . GLN B 2 161 ? 3.38745   7.20231   2.42330   1.000 48.09247  ? 493 GLN B NE2 1 
ATOM   1567 N N   . SER B 2 162 ? 5.73914   3.19530   3.18814   1.000 41.26071  ? 494 SER B N   1 
ATOM   1568 C CA  . SER B 2 162 ? 6.61370   2.06169   2.92843   1.000 42.12796  ? 494 SER B CA  1 
ATOM   1569 C C   . SER B 2 162 ? 8.07710   2.48067   2.99703   1.000 37.57379  ? 494 SER B C   1 
ATOM   1570 O O   . SER B 2 162 ? 8.44039   3.61217   2.66380   1.000 36.23502  ? 494 SER B O   1 
ATOM   1571 C CB  . SER B 2 162 ? 6.32868   1.43048   1.56448   1.000 43.72108  ? 494 SER B CB  1 
ATOM   1572 O OG  . SER B 2 162 ? 7.20596   0.33225   1.34466   1.000 43.22549  ? 494 SER B OG  1 
ATOM   1573 N N   . TYR B 2 163 ? 8.91636   1.54811   3.45258   1.000 32.84565  ? 495 TYR B N   1 
ATOM   1574 C CA  . TYR B 2 163 ? 10.35705  1.77442   3.44024   1.000 34.44436  ? 495 TYR B CA  1 
ATOM   1575 C C   . TYR B 2 163 ? 10.92360  1.66845   2.02742   1.000 39.71030  ? 495 TYR B C   1 
ATOM   1576 O O   . TYR B 2 163 ? 11.90206  2.34633   1.69476   1.000 37.04514  ? 495 TYR B O   1 
ATOM   1577 C CB  . TYR B 2 163 ? 11.05192  0.76597   4.34776   1.000 39.94915  ? 495 TYR B CB  1 
ATOM   1578 C CG  . TYR B 2 163 ? 10.86425  0.96679   5.83189   1.000 33.03555  ? 495 TYR B CG  1 
ATOM   1579 C CD1 . TYR B 2 163 ? 11.53017  1.98195   6.50107   1.000 37.52393  ? 495 TYR B CD1 1 
ATOM   1580 C CD2 . TYR B 2 163 ? 10.05589  0.11057   6.57298   1.000 38.54946  ? 495 TYR B CD2 1 
ATOM   1581 C CE1 . TYR B 2 163 ? 11.38094  2.15434   7.86509   1.000 38.69931  ? 495 TYR B CE1 1 
ATOM   1582 C CE2 . TYR B 2 163 ? 9.90162   0.27549   7.94253   1.000 35.17409  ? 495 TYR B CE2 1 
ATOM   1583 C CZ  . TYR B 2 163 ? 10.56925  1.30088   8.58024   1.000 33.89020  ? 495 TYR B CZ  1 
ATOM   1584 O OH  . TYR B 2 163 ? 10.43523  1.48399   9.93560   1.000 37.56149  ? 495 TYR B OH  1 
ATOM   1585 N N   . GLY B 2 164 ? 10.33782  0.80498   1.19547   1.000 36.38751  ? 496 GLY B N   1 
ATOM   1586 C CA  . GLY B 2 164 ? 10.79307  0.58686   -0.16532  1.000 40.52791  ? 496 GLY B CA  1 
ATOM   1587 C C   . GLY B 2 164 ? 12.23736  0.14184   -0.27141  1.000 41.77350  ? 496 GLY B C   1 
ATOM   1588 O O   . GLY B 2 164 ? 12.97211  0.64047   -1.12928  1.000 37.12788  ? 496 GLY B O   1 
ATOM   1589 N N   . PHE B 2 165 ? 12.64526  -0.80400  0.58053   1.000 36.31163  ? 497 PHE B N   1 
ATOM   1590 C CA  . PHE B 2 165 ? 14.05515  -1.16739  0.71631   1.000 38.03956  ? 497 PHE B CA  1 
ATOM   1591 C C   . PHE B 2 165 ? 14.66971  -1.58252  -0.61905  1.000 36.51429  ? 497 PHE B C   1 
ATOM   1592 O O   . PHE B 2 165 ? 14.09281  -2.38111  -1.36196  1.000 35.62520  ? 497 PHE B O   1 
ATOM   1593 C CB  . PHE B 2 165 ? 14.20750  -2.30729  1.72644   1.000 38.83942  ? 497 PHE B CB  1 
ATOM   1594 C CG  . PHE B 2 165 ? 13.89528  -1.92127  3.14874   1.000 39.01501  ? 497 PHE B CG  1 
ATOM   1595 C CD1 . PHE B 2 165 ? 14.66392  -0.97207  3.81225   1.000 41.05791  ? 497 PHE B CD1 1 
ATOM   1596 C CD2 . PHE B 2 165 ? 12.85875  -2.53593  3.83606   1.000 38.05369  ? 497 PHE B CD2 1 
ATOM   1597 C CE1 . PHE B 2 165 ? 14.39254  -0.62660  5.13127   1.000 41.28118  ? 497 PHE B CE1 1 
ATOM   1598 C CE2 . PHE B 2 165 ? 12.58400  -2.20046  5.16028   1.000 36.05149  ? 497 PHE B CE2 1 
ATOM   1599 C CZ  . PHE B 2 165 ? 13.35406  -1.24494  5.80683   1.000 35.60780  ? 497 PHE B CZ  1 
ATOM   1600 N N   . ARG B 2 166 ? 15.85294  -1.04767  -0.91034  1.000 35.66734  ? 498 ARG B N   1 
ATOM   1601 C CA  . ARG B 2 166 ? 16.63788  -1.39813  -2.08414  1.000 41.47966  ? 498 ARG B CA  1 
ATOM   1602 C C   . ARG B 2 166 ? 18.05152  -1.77872  -1.66919  1.000 44.91847  ? 498 ARG B C   1 
ATOM   1603 O O   . ARG B 2 166 ? 18.59829  -1.20992  -0.71641  1.000 41.31916  ? 498 ARG B O   1 
ATOM   1604 C CB  . ARG B 2 166 ? 16.69924  -0.23457  -3.08375  1.000 39.59119  ? 498 ARG B CB  1 
ATOM   1605 C CG  . ARG B 2 166 ? 15.38868  0.05955   -3.79045  1.000 39.97337  ? 498 ARG B CG  1 
ATOM   1606 C CD  . ARG B 2 166 ? 15.45661  1.40483   -4.49035  1.000 36.31251  ? 498 ARG B CD  1 
ATOM   1607 N NE  . ARG B 2 166 ? 14.25369  1.68931   -5.26146  1.000 40.48136  ? 498 ARG B NE  1 
ATOM   1608 C CZ  . ARG B 2 166 ? 13.11562  2.14558   -4.75529  1.000 55.16474  ? 498 ARG B CZ  1 
ATOM   1609 N NH1 . ARG B 2 166 ? 12.96689  2.34822   -3.45403  1.000 41.86645  ? 498 ARG B NH1 1 
ATOM   1610 N NH2 . ARG B 2 166 ? 12.10074  2.40459   -5.57842  1.000 55.88610  ? 498 ARG B NH2 1 
ATOM   1611 N N   . PRO B 2 167 ? 18.67245  -2.72990  -2.37613  1.000 45.77265  ? 499 PRO B N   1 
ATOM   1612 C CA  . PRO B 2 167 ? 20.01317  -3.19624  -1.97356  1.000 44.69788  ? 499 PRO B CA  1 
ATOM   1613 C C   . PRO B 2 167 ? 21.06367  -2.10285  -1.93886  1.000 45.64094  ? 499 PRO B C   1 
ATOM   1614 O O   . PRO B 2 167 ? 22.07385  -2.26012  -1.24314  1.000 52.05189  ? 499 PRO B O   1 
ATOM   1615 C CB  . PRO B 2 167 ? 20.35278  -4.25142  -3.03747  1.000 44.93879  ? 499 PRO B CB  1 
ATOM   1616 C CG  . PRO B 2 167 ? 19.03673  -4.68151  -3.59351  1.000 42.40863  ? 499 PRO B CG  1 
ATOM   1617 C CD  . PRO B 2 167 ? 18.15406  -3.46941  -3.54091  1.000 46.46728  ? 499 PRO B CD  1 
ATOM   1618 N N   . THR B 2 168 ? 20.86097  -1.00275  -2.65609  1.000 41.52208  ? 500 THR B N   1 
ATOM   1619 C CA  . THR B 2 168 ? 21.85383  0.05546   -2.76083  1.000 43.64070  ? 500 THR B CA  1 
ATOM   1620 C C   . THR B 2 168 ? 21.70984  1.12324   -1.68405  1.000 43.77599  ? 500 THR B C   1 
ATOM   1621 O O   . THR B 2 168 ? 22.45271  2.10979   -1.70836  1.000 43.31244  ? 500 THR B O   1 
ATOM   1622 C CB  . THR B 2 168 ? 21.77596  0.70373   -4.14691  1.000 49.84951  ? 500 THR B CB  1 
ATOM   1623 O OG1 . THR B 2 168 ? 20.45225  1.20684   -4.36574  1.000 45.61703  ? 500 THR B OG1 1 
ATOM   1624 C CG2 . THR B 2 168 ? 22.10858  -0.31965  -5.22528  1.000 40.31041  ? 500 THR B CG2 1 
ATOM   1625 N N   . TYR B 2 169 ? 20.77688  0.95985   -0.75018  1.000 46.75606  ? 501 TYR B N   1 
ATOM   1626 C CA  . TYR B 2 169 ? 20.65557  1.90981   0.34594   1.000 43.03585  ? 501 TYR B CA  1 
ATOM   1627 C C   . TYR B 2 169 ? 21.92272  1.91170   1.19336   1.000 40.46555  ? 501 TYR B C   1 
ATOM   1628 O O   . TYR B 2 169 ? 22.60746  0.89383   1.33132   1.000 40.46354  ? 501 TYR B O   1 
ATOM   1629 C CB  . TYR B 2 169 ? 19.46766  1.55913   1.24178   1.000 40.56468  ? 501 TYR B CB  1 
ATOM   1630 C CG  . TYR B 2 169 ? 18.09185  1.98516   0.77037   1.000 42.01760  ? 501 TYR B CG  1 
ATOM   1631 C CD1 . TYR B 2 169 ? 17.88953  2.56948   -0.47881  1.000 40.79578  ? 501 TYR B CD1 1 
ATOM   1632 C CD2 . TYR B 2 169 ? 16.98454  1.79967   1.59834   1.000 39.52241  ? 501 TYR B CD2 1 
ATOM   1633 C CE1 . TYR B 2 169 ? 16.61310  2.95075   -0.88849  1.000 41.76450  ? 501 TYR B CE1 1 
ATOM   1634 C CE2 . TYR B 2 169 ? 15.71896  2.17364   1.20390   1.000 40.95956  ? 501 TYR B CE2 1 
ATOM   1635 C CZ  . TYR B 2 169 ? 15.53419  2.75028   -0.03534  1.000 42.75819  ? 501 TYR B CZ  1 
ATOM   1636 O OH  . TYR B 2 169 ? 14.25981  3.12044   -0.40338  1.000 43.48749  ? 501 TYR B OH  1 
ATOM   1637 N N   . GLY B 2 170 ? 22.22728  3.06912   1.77564   1.000 38.26782  ? 502 GLY B N   1 
ATOM   1638 C CA  . GLY B 2 170 ? 23.21412  3.11254   2.83525   1.000 43.49264  ? 502 GLY B CA  1 
ATOM   1639 C C   . GLY B 2 170 ? 22.84033  2.19718   3.98643   1.000 46.36417  ? 502 GLY B C   1 
ATOM   1640 O O   . GLY B 2 170 ? 21.67774  1.83403   4.17945   1.000 41.26144  ? 502 GLY B O   1 
ATOM   1641 N N   . VAL B 2 171 ? 23.85677  1.80889   4.76147   1.000 43.81379  ? 503 VAL B N   1 
ATOM   1642 C CA  . VAL B 2 171 ? 23.64126  0.82598   5.82046   1.000 46.06929  ? 503 VAL B CA  1 
ATOM   1643 C C   . VAL B 2 171 ? 22.64344  1.34330   6.85242   1.000 43.18779  ? 503 VAL B C   1 
ATOM   1644 O O   . VAL B 2 171 ? 21.83450  0.57250   7.38599   1.000 44.04045  ? 503 VAL B O   1 
ATOM   1645 C CB  . VAL B 2 171 ? 24.98933  0.42895   6.46170   1.000 48.05075  ? 503 VAL B CB  1 
ATOM   1646 C CG1 . VAL B 2 171 ? 25.65719  1.63340   7.11867   1.000 47.31467  ? 503 VAL B CG1 1 
ATOM   1647 C CG2 . VAL B 2 171 ? 24.79550  -0.70435  7.45550   1.000 44.11434  ? 503 VAL B CG2 1 
ATOM   1648 N N   . GLY B 2 172 ? 22.66033  2.64915   7.13122   1.000 41.61617  ? 504 GLY B N   1 
ATOM   1649 C CA  . GLY B 2 172 ? 21.69315  3.22324   8.04732   1.000 37.17228  ? 504 GLY B CA  1 
ATOM   1650 C C   . GLY B 2 172 ? 20.25920  3.11299   7.57915   1.000 44.72224  ? 504 GLY B C   1 
ATOM   1651 O O   . GLY B 2 172 ? 19.34570  3.17312   8.40678   1.000 39.84791  ? 504 GLY B O   1 
ATOM   1652 N N   . HIS B 2 173 ? 20.03966  2.94204   6.27411   1.000 40.92825  ? 505 HIS B N   1 
ATOM   1653 C CA  . HIS B 2 173 ? 18.69991  2.83209   5.71664   1.000 36.06453  ? 505 HIS B CA  1 
ATOM   1654 C C   . HIS B 2 173 ? 18.33516  1.41611   5.29804   1.000 40.10234  ? 505 HIS B C   1 
ATOM   1655 O O   . HIS B 2 173 ? 17.19489  1.18453   4.88445   1.000 37.70219  ? 505 HIS B O   1 
ATOM   1656 C CB  . HIS B 2 173 ? 18.54878  3.77996   4.52442   1.000 41.65664  ? 505 HIS B CB  1 
ATOM   1657 C CG  . HIS B 2 173 ? 18.69923  5.22417   4.88613   1.000 43.93229  ? 505 HIS B CG  1 
ATOM   1658 N ND1 . HIS B 2 173 ? 19.60883  6.05441   4.26901   1.000 49.13570  ? 505 HIS B ND1 1 
ATOM   1659 C CD2 . HIS B 2 173 ? 18.05304  5.98709   5.79901   1.000 38.91979  ? 505 HIS B CD2 1 
ATOM   1660 C CE1 . HIS B 2 173 ? 19.51931  7.26565   4.78839   1.000 43.82806  ? 505 HIS B CE1 1 
ATOM   1661 N NE2 . HIS B 2 173 ? 18.58324  7.25146   5.71923   1.000 43.37473  ? 505 HIS B NE2 1 
ATOM   1662 N N   . GLN B 2 174 ? 19.25939  0.46510   5.40138   1.000 42.15889  ? 506 GLN B N   1 
ATOM   1663 C CA  . GLN B 2 174 ? 18.95997  -0.90997  5.04763   1.000 37.92296  ? 506 GLN B CA  1 
ATOM   1664 C C   . GLN B 2 174 ? 18.01943  -1.52746  6.08086   1.000 40.75831  ? 506 GLN B C   1 
ATOM   1665 O O   . GLN B 2 174 ? 17.87990  -1.01322  7.19389   1.000 40.57199  ? 506 GLN B O   1 
ATOM   1666 C CB  . GLN B 2 174 ? 20.25298  -1.71558  4.93436   1.000 41.26353  ? 506 GLN B CB  1 
ATOM   1667 C CG  . GLN B 2 174 ? 21.13100  -1.26215  3.77751   1.000 45.06833  ? 506 GLN B CG  1 
ATOM   1668 C CD  . GLN B 2 174 ? 22.40204  -2.07513  3.63596   1.000 47.40330  ? 506 GLN B CD  1 
ATOM   1669 O OE1 . GLN B 2 174 ? 22.58847  -3.08626  4.31244   1.000 46.04726  ? 506 GLN B OE1 1 
ATOM   1670 N NE2 . GLN B 2 174 ? 23.28656  -1.63441  2.74708   1.000 48.00721  ? 506 GLN B NE2 1 
ATOM   1671 N N   . PRO B 2 175 ? 17.33732  -2.61670  5.72601   1.000 41.06227  ? 507 PRO B N   1 
ATOM   1672 C CA  . PRO B 2 175 ? 16.41914  -3.24385  6.68408   1.000 38.15342  ? 507 PRO B CA  1 
ATOM   1673 C C   . PRO B 2 175 ? 17.16493  -4.03308  7.74846   1.000 45.52940  ? 507 PRO B C   1 
ATOM   1674 O O   . PRO B 2 175 ? 18.18442  -4.67316  7.47900   1.000 45.77479  ? 507 PRO B O   1 
ATOM   1675 C CB  . PRO B 2 175 ? 15.56692  -4.16488  5.80766   1.000 39.51483  ? 507 PRO B CB  1 
ATOM   1676 C CG  . PRO B 2 175 ? 16.45439  -4.49006  4.65282   1.000 43.76052  ? 507 PRO B CG  1 
ATOM   1677 C CD  . PRO B 2 175 ? 17.26541  -3.25130  4.39769   1.000 34.18097  ? 507 PRO B CD  1 
ATOM   1678 N N   . TYR B 2 176 ? 16.64039  -3.98229  8.96978   1.000 38.87391  ? 508 TYR B N   1 
ATOM   1679 C CA  . TYR B 2 176 ? 17.13557  -4.79351  10.07262  1.000 41.69004  ? 508 TYR B CA  1 
ATOM   1680 C C   . TYR B 2 176 ? 15.97165  -5.57157  10.66138  1.000 41.01748  ? 508 TYR B C   1 
ATOM   1681 O O   . TYR B 2 176 ? 14.91641  -4.99707  10.94736  1.000 41.63353  ? 508 TYR B O   1 
ATOM   1682 C CB  . TYR B 2 176 ? 17.81356  -3.93032  11.14440  1.000 37.61115  ? 508 TYR B CB  1 
ATOM   1683 C CG  . TYR B 2 176 ? 19.23925  -3.56904  10.79665  1.000 42.83244  ? 508 TYR B CG  1 
ATOM   1684 C CD1 . TYR B 2 176 ? 19.52252  -2.82382  9.66025   1.000 42.72533  ? 508 TYR B CD1 1 
ATOM   1685 C CD2 . TYR B 2 176 ? 20.30343  -3.98168  11.59402  1.000 43.25765  ? 508 TYR B CD2 1 
ATOM   1686 C CE1 . TYR B 2 176 ? 20.81765  -2.49480  9.32366   1.000 44.34028  ? 508 TYR B CE1 1 
ATOM   1687 C CE2 . TYR B 2 176 ? 21.60870  -3.65485  11.26550  1.000 48.07443  ? 508 TYR B CE2 1 
ATOM   1688 C CZ  . TYR B 2 176 ? 21.85794  -2.91275  10.12434  1.000 50.81897  ? 508 TYR B CZ  1 
ATOM   1689 O OH  . TYR B 2 176 ? 23.14989  -2.58108  9.77946   1.000 49.99318  ? 508 TYR B OH  1 
ATOM   1690 N N   . ARG B 2 177 ? 16.15065  -6.87948  10.80531  1.000 42.87652  ? 509 ARG B N   1 
ATOM   1691 C CA  . ARG B 2 177 ? 15.19070  -7.68983  11.53755  1.000 39.61312  ? 509 ARG B CA  1 
ATOM   1692 C C   . ARG B 2 177 ? 15.49322  -7.58265  13.02583  1.000 47.00963  ? 509 ARG B C   1 
ATOM   1693 O O   . ARG B 2 177 ? 16.64990  -7.70303  13.44058  1.000 47.44215  ? 509 ARG B O   1 
ATOM   1694 C CB  . ARG B 2 177 ? 15.24584  -9.14328  11.06948  1.000 39.94888  ? 509 ARG B CB  1 
ATOM   1695 C CG  . ARG B 2 177 ? 14.62384  -9.35975  9.69702   1.000 47.81960  ? 509 ARG B CG  1 
ATOM   1696 C CD  . ARG B 2 177 ? 15.06047  -10.67158 9.05926   1.000 50.42337  ? 509 ARG B CD  1 
ATOM   1697 N NE  . ARG B 2 177 ? 14.47142  -10.82479 7.73484   1.000 48.66396  ? 509 ARG B NE  1 
ATOM   1698 C CZ  . ARG B 2 177 ? 13.65172  -11.80474 7.38204   1.000 49.96669  ? 509 ARG B CZ  1 
ATOM   1699 N NH1 . ARG B 2 177 ? 13.36550  -12.79904 8.20610   1.000 48.40487  ? 509 ARG B NH1 1 
ATOM   1700 N NH2 . ARG B 2 177 ? 13.11180  -11.79142 6.16708   1.000 51.88368  ? 509 ARG B NH2 1 
ATOM   1701 N N   . VAL B 2 178 ? 14.45846  -7.33104  13.82335  1.000 44.81822  ? 510 VAL B N   1 
ATOM   1702 C CA  . VAL B 2 178 ? 14.59808  -7.08832  15.25320  1.000 43.32669  ? 510 VAL B CA  1 
ATOM   1703 C C   . VAL B 2 178 ? 13.74564  -8.10158  16.00399  1.000 48.50278  ? 510 VAL B C   1 
ATOM   1704 O O   . VAL B 2 178 ? 12.60441  -8.37416  15.61565  1.000 46.06164  ? 510 VAL B O   1 
ATOM   1705 C CB  . VAL B 2 178 ? 14.18839  -5.64561  15.62406  1.000 46.41393  ? 510 VAL B CB  1 
ATOM   1706 C CG1 . VAL B 2 178 ? 14.32235  -5.41176  17.12123  1.000 40.34063  ? 510 VAL B CG1 1 
ATOM   1707 C CG2 . VAL B 2 178 ? 15.01896  -4.63465  14.84435  1.000 42.19842  ? 510 VAL B CG2 1 
ATOM   1708 N N   . VAL B 2 179 ? 14.30364  -8.66274  17.07618  1.000 48.90023  ? 511 VAL B N   1 
ATOM   1709 C CA  . VAL B 2 179 ? 13.58285  -9.56420  17.96787  1.000 45.18759  ? 511 VAL B CA  1 
ATOM   1710 C C   . VAL B 2 179 ? 13.69921  -9.02805  19.38689  1.000 46.28746  ? 511 VAL B C   1 
ATOM   1711 O O   . VAL B 2 179 ? 14.80854  -8.76954  19.86898  1.000 43.95787  ? 511 VAL B O   1 
ATOM   1712 C CB  . VAL B 2 179 ? 14.11907  -11.00611 17.89507  1.000 53.29590  ? 511 VAL B CB  1 
ATOM   1713 C CG1 . VAL B 2 179 ? 13.41459  -11.88294 18.92434  1.000 48.30231  ? 511 VAL B CG1 1 
ATOM   1714 C CG2 . VAL B 2 179 ? 13.93448  -11.57295 16.49779  1.000 48.05139  ? 511 VAL B CG2 1 
ATOM   1715 N N   . VAL B 2 180 ? 12.55962  -8.86061  20.05192  1.000 42.49877  ? 512 VAL B N   1 
ATOM   1716 C CA  . VAL B 2 180 ? 12.50789  -8.36025  21.42011  1.000 42.18360  ? 512 VAL B CA  1 
ATOM   1717 C C   . VAL B 2 180 ? 11.98024  -9.47701  22.30765  1.000 47.55350  ? 512 VAL B C   1 
ATOM   1718 O O   . VAL B 2 180 ? 10.88791  -10.00856 22.06764  1.000 47.12441  ? 512 VAL B O   1 
ATOM   1719 C CB  . VAL B 2 180 ? 11.62907  -7.10708  21.53764  1.000 45.62959  ? 512 VAL B CB  1 
ATOM   1720 C CG1 . VAL B 2 180 ? 11.64998  -6.57887  22.96891  1.000 43.72628  ? 512 VAL B CG1 1 
ATOM   1721 C CG2 . VAL B 2 180 ? 12.09698  -6.03963  20.56493  1.000 43.12315  ? 512 VAL B CG2 1 
ATOM   1722 N N   . LEU B 2 181 ? 12.75299  -9.83306  23.32971  1.000 49.35903  ? 513 LEU B N   1 
ATOM   1723 C CA  . LEU B 2 181 ? 12.37663  -10.87125 24.28179  1.000 50.82114  ? 513 LEU B CA  1 
ATOM   1724 C C   . LEU B 2 181 ? 12.01270  -10.21440 25.60634  1.000 49.47894  ? 513 LEU B C   1 
ATOM   1725 O O   . LEU B 2 181 ? 12.82633  -9.48676  26.18653  1.000 48.49212  ? 513 LEU B O   1 
ATOM   1726 C CB  . LEU B 2 181 ? 13.51030  -11.87964 24.47216  1.000 49.17977  ? 513 LEU B CB  1 
ATOM   1727 C CG  . LEU B 2 181 ? 13.95582  -12.63834 23.22003  1.000 55.38261  ? 513 LEU B CG  1 
ATOM   1728 C CD1 . LEU B 2 181 ? 15.12482  -13.55126 23.54174  1.000 53.12975  ? 513 LEU B CD1 1 
ATOM   1729 C CD2 . LEU B 2 181 ? 12.80009  -13.42810 22.62113  1.000 49.12272  ? 513 LEU B CD2 1 
ATOM   1730 N N   . SER B 2 182 ? 10.79056  -10.45961 26.06992  1.000 48.22086  ? 514 SER B N   1 
ATOM   1731 C CA  . SER B 2 182 ? 10.31979  -9.98654  27.36276  1.000 54.41425  ? 514 SER B CA  1 
ATOM   1732 C C   . SER B 2 182 ? 9.96344   -11.18776 28.22866  1.000 60.51805  ? 514 SER B C   1 
ATOM   1733 O O   . SER B 2 182 ? 9.38994   -12.16735 27.74095  1.000 56.81478  ? 514 SER B O   1 
ATOM   1734 C CB  . SER B 2 182 ? 9.10977   -9.05776  27.20729  1.000 48.82168  ? 514 SER B CB  1 
ATOM   1735 O OG  . SER B 2 182 ? 8.01251   -9.74939  26.63828  1.000 63.62079  ? 514 SER B OG  1 
ATOM   1736 N N   . PHE B 2 183 ? 10.31221  -11.11347 29.51078  1.000 64.76628  ? 515 PHE B N   1 
ATOM   1737 C CA  . PHE B 2 183 ? 10.18689  -12.23903 30.43113  1.000 68.18675  ? 515 PHE B CA  1 
ATOM   1738 C C   . PHE B 2 183 ? 9.13263   -11.92397 31.48286  1.000 67.10727  ? 515 PHE B C   1 
ATOM   1739 O O   . PHE B 2 183 ? 9.32221   -11.02598 32.31048  1.000 64.58724  ? 515 PHE B O   1 
ATOM   1740 C CB  . PHE B 2 183 ? 11.52895  -12.55054 31.08751  1.000 62.42126  ? 515 PHE B CB  1 
ATOM   1741 C CG  . PHE B 2 183 ? 12.63115  -12.79260 30.10609  1.000 63.98797  ? 515 PHE B CG  1 
ATOM   1742 C CD1 . PHE B 2 183 ? 12.88151  -14.06752 29.62830  1.000 68.56653  ? 515 PHE B CD1 1 
ATOM   1743 C CD2 . PHE B 2 183 ? 13.41041  -11.74249 29.65054  1.000 55.79586  ? 515 PHE B CD2 1 
ATOM   1744 C CE1 . PHE B 2 183 ? 13.89612  -14.29317 28.72032  1.000 71.46418  ? 515 PHE B CE1 1 
ATOM   1745 C CE2 . PHE B 2 183 ? 14.42590  -11.95972 28.74406  1.000 59.49559  ? 515 PHE B CE2 1 
ATOM   1746 C CZ  . PHE B 2 183 ? 14.66998  -13.23655 28.27687  1.000 67.46088  ? 515 PHE B CZ  1 
ATOM   1747 N N   . GLU B 2 184 ? 8.03562   -12.67297 31.45676  1.000 66.70817  ? 516 GLU B N   1 
ATOM   1748 C CA  . GLU B 2 184 ? 6.88021   -12.42223 32.30735  1.000 73.96201  ? 516 GLU B CA  1 
ATOM   1749 C C   . GLU B 2 184 ? 6.85240   -13.43518 33.44435  1.000 82.97107  ? 516 GLU B C   1 
ATOM   1750 O O   . GLU B 2 184 ? 6.83362   -14.64691 33.20109  1.000 79.83778  ? 516 GLU B O   1 
ATOM   1751 C CB  . GLU B 2 184 ? 5.59029   -12.49961 31.49379  1.000 71.49342  ? 516 GLU B CB  1 
ATOM   1752 C CG  . GLU B 2 184 ? 4.33797   -12.19755 32.28925  1.000 76.60544  ? 516 GLU B CG  1 
ATOM   1753 C CD  . GLU B 2 184 ? 3.07564   -12.48686 31.50532  1.000 78.22730  ? 516 GLU B CD  1 
ATOM   1754 O OE1 . GLU B 2 184 ? 3.01764   -13.54463 30.84256  1.000 83.86956  ? 516 GLU B OE1 1 
ATOM   1755 O OE2 . GLU B 2 184 ? 2.14515   -11.65454 31.54566  1.000 74.99045  ? 516 GLU B OE2 1 
ATOM   1756 N N   . LEU B 2 185 ? 6.83799   -12.93930 34.67858  1.000 84.11766  ? 517 LEU B N   1 
ATOM   1757 C CA  . LEU B 2 185 ? 6.70842   -13.77631 35.87013  1.000 88.76738  ? 517 LEU B CA  1 
ATOM   1758 C C   . LEU B 2 185 ? 5.36538   -13.45106 36.51869  1.000 87.44841  ? 517 LEU B C   1 
ATOM   1759 O O   . LEU B 2 185 ? 5.22292   -12.43051 37.19917  1.000 85.44262  ? 517 LEU B O   1 
ATOM   1760 C CB  . LEU B 2 185 ? 7.87461   -13.55373 36.83315  1.000 88.84131  ? 517 LEU B CB  1 
ATOM   1761 C CG  . LEU B 2 185 ? 8.02029   -14.51863 38.01633  1.000 95.30292  ? 517 LEU B CG  1 
ATOM   1762 C CD1 . LEU B 2 185 ? 9.48712   -14.70841 38.36871  1.000 95.96684  ? 517 LEU B CD1 1 
ATOM   1763 C CD2 . LEU B 2 185 ? 7.24787   -14.03072 39.23700  1.000 91.51254  ? 517 LEU B CD2 1 
ATOM   1764 N N   . LEU B 2 186 ? 4.38418   -14.31826 36.29510  1.000 88.03563  ? 518 LEU B N   1 
ATOM   1765 C CA  . LEU B 2 186 ? 3.06506   -14.20448 36.89618  1.000 94.56802  ? 518 LEU B CA  1 
ATOM   1766 C C   . LEU B 2 186 ? 2.98356   -15.06925 38.15119  1.000 103.69689 ? 518 LEU B C   1 
ATOM   1767 O O   . LEU B 2 186 ? 3.89395   -15.83719 38.47372  1.000 100.92158 ? 518 LEU B O   1 
ATOM   1768 C CB  . LEU B 2 186 ? 1.98107   -14.62195 35.89669  1.000 91.71374  ? 518 LEU B CB  1 
ATOM   1769 C CG  . LEU B 2 186 ? 1.90070   -13.85711 34.57426  1.000 87.54602  ? 518 LEU B CG  1 
ATOM   1770 C CD1 . LEU B 2 186 ? 0.84196   -14.46804 33.66564  1.000 79.65453  ? 518 LEU B CD1 1 
ATOM   1771 C CD2 . LEU B 2 186 ? 1.60974   -12.38853 34.83137  1.000 85.94316  ? 518 LEU B CD2 1 
ATOM   1772 N N   . HIS B 2 187 ? 1.86754   -14.93238 38.86955  1.000 106.12823 ? 519 HIS B N   1 
ATOM   1773 C CA  . HIS B 2 187 ? 1.56762   -15.80680 40.00502  1.000 107.29968 ? 519 HIS B CA  1 
ATOM   1774 C C   . HIS B 2 187 ? 0.98549   -17.11531 39.46680  1.000 105.92823 ? 519 HIS B C   1 
ATOM   1775 O O   . HIS B 2 187 ? -0.18957  -17.44598 39.64398  1.000 105.01286 ? 519 HIS B O   1 
ATOM   1776 C CB  . HIS B 2 187 ? 0.62117   -15.12249 40.98216  1.000 101.78619 ? 519 HIS B CB  1 
ATOM   1777 N N   . ALA B 2 188 ? 1.84857   -17.86551 38.78929  1.000 97.45750  ? 520 ALA B N   1 
ATOM   1778 C CA  . ALA B 2 188 ? 1.45525   -19.07307 38.08054  1.000 95.56785  ? 520 ALA B CA  1 
ATOM   1779 C C   . ALA B 2 188 ? 2.69625   -19.93310 37.88402  1.000 101.46734 ? 520 ALA B C   1 
ATOM   1780 O O   . ALA B 2 188 ? 3.82216   -19.44927 38.06087  1.000 98.57898  ? 520 ALA B O   1 
ATOM   1781 C CB  . ALA B 2 188 ? 0.80352   -18.73234 36.72912  1.000 95.31298  ? 520 ALA B CB  1 
ATOM   1782 N N   . PRO B 2 189 ? 2.52656   -21.22114 37.54148  1.000 100.35092 ? 521 PRO B N   1 
ATOM   1783 C CA  . PRO B 2 189 ? 3.69624   -22.07313 37.27603  1.000 92.33382  ? 521 PRO B CA  1 
ATOM   1784 C C   . PRO B 2 189 ? 4.63918   -21.50691 36.22323  1.000 88.65998  ? 521 PRO B C   1 
ATOM   1785 O O   . PRO B 2 189 ? 4.23140   -21.23695 35.08875  1.000 87.40022  ? 521 PRO B O   1 
ATOM   1786 C CB  . PRO B 2 189 ? 3.06369   -23.38680 36.80343  1.000 89.13493  ? 521 PRO B CB  1 
ATOM   1787 C CG  . PRO B 2 189 ? 1.75168   -23.42668 37.49761  1.000 89.64970  ? 521 PRO B CG  1 
ATOM   1788 C CD  . PRO B 2 189 ? 1.27562   -22.00291 37.58018  1.000 89.96721  ? 521 PRO B CD  1 
ATOM   1789 N N   . ALA B 2 190 ? 5.90571   -21.32823 36.59653  1.000 87.54645  ? 522 ALA B N   1 
ATOM   1790 C CA  . ALA B 2 190 ? 6.93630   -20.83093 35.68630  1.000 86.32498  ? 522 ALA B CA  1 
ATOM   1791 C C   . ALA B 2 190 ? 7.34431   -21.96537 34.75470  1.000 90.39195  ? 522 ALA B C   1 
ATOM   1792 O O   . ALA B 2 190 ? 8.20804   -22.78133 35.08646  1.000 89.54579  ? 522 ALA B O   1 
ATOM   1793 C CB  . ALA B 2 190 ? 8.13041   -20.29419 36.46704  1.000 80.59821  ? 522 ALA B CB  1 
ATOM   1794 N N   . THR B 2 191 ? 6.73058   -22.00858 33.57320  1.000 89.82721  ? 523 THR B N   1 
ATOM   1795 C CA  . THR B 2 191 ? 6.88957   -23.11384 32.63915  1.000 86.56740  ? 523 THR B CA  1 
ATOM   1796 C C   . THR B 2 191 ? 7.93324   -22.84323 31.55651  1.000 89.10976  ? 523 THR B C   1 
ATOM   1797 O O   . THR B 2 191 ? 8.02908   -23.61580 30.59634  1.000 87.54251  ? 523 THR B O   1 
ATOM   1798 C CB  . THR B 2 191 ? 5.54011   -23.44398 31.99781  1.000 90.27359  ? 523 THR B CB  1 
ATOM   1799 O OG1 . THR B 2 191 ? 5.64184   -24.67361 31.27042  1.000 99.61149  ? 523 THR B OG1 1 
ATOM   1800 C CG2 . THR B 2 191 ? 5.10510   -22.32742 31.05443  1.000 90.09495  ? 523 THR B CG2 1 
ATOM   1801 N N   . VAL B 2 192 ? 8.71475   -21.77190 31.68378  1.000 87.94760  ? 524 VAL B N   1 
ATOM   1802 C CA  . VAL B 2 192 ? 9.79562   -21.45891 30.74907  1.000 86.18521  ? 524 VAL B CA  1 
ATOM   1803 C C   . VAL B 2 192 ? 11.06244  -21.30338 31.57910  1.000 86.07628  ? 524 VAL B C   1 
ATOM   1804 O O   . VAL B 2 192 ? 11.24595  -20.28590 32.25557  1.000 91.77888  ? 524 VAL B O   1 
ATOM   1805 C CB  . VAL B 2 192 ? 9.52321   -20.19398 29.92791  1.000 86.66903  ? 524 VAL B CB  1 
ATOM   1806 C CG1 . VAL B 2 192 ? 10.48721  -20.11085 28.75236  1.000 81.05768  ? 524 VAL B CG1 1 
ATOM   1807 C CG2 . VAL B 2 192 ? 8.08327   -20.15902 29.45413  1.000 85.65958  ? 524 VAL B CG2 1 
ATOM   1808 N N   . CYS B 2 193 ? 11.94297  -22.29762 31.52522  1.000 86.42228  ? 525 CYS B N   1 
ATOM   1809 C CA  . CYS B 2 193 ? 13.16960  -22.28933 32.30503  1.000 88.47041  ? 525 CYS B CA  1 
ATOM   1810 C C   . CYS B 2 193 ? 14.38191  -22.34299 31.38661  1.000 90.09385  ? 525 CYS B C   1 
ATOM   1811 O O   . CYS B 2 193 ? 14.28240  -22.68384 30.20459  1.000 91.79758  ? 525 CYS B O   1 
ATOM   1812 C CB  . CYS B 2 193 ? 13.21662  -23.46520 33.28704  1.000 92.55461  ? 525 CYS B CB  1 
ATOM   1813 S SG  . CYS B 2 193 ? 11.99414  -23.40372 34.61528  1.000 103.15692 ? 525 CYS B SG  1 
ATOM   1814 N N   . GLY B 2 194 ? 15.53527  -22.00986 31.95456  1.000 88.86906  ? 526 GLY B N   1 
ATOM   1815 C CA  . GLY B 2 194 ? 16.78703  -22.00321 31.23043  1.000 94.91920  ? 526 GLY B CA  1 
ATOM   1816 C C   . GLY B 2 194 ? 17.48266  -23.34742 31.25177  1.000 97.21029  ? 526 GLY B C   1 
ATOM   1817 O O   . GLY B 2 194 ? 16.89973  -24.37947 31.59329  1.000 97.10284  ? 526 GLY B O   1 
ATOM   1818 N N   . SER B 2 195 ? 18.76252  -23.32574 30.87753  1.000 97.06338  ? 527 SER B N   1 
ATOM   1819 C CA  . SER B 2 195 ? 19.55283  -24.55110 30.83701  1.000 99.02952  ? 527 SER B CA  1 
ATOM   1820 C C   . SER B 2 195 ? 20.06140  -24.93348 32.22333  1.000 100.95741 ? 527 SER B C   1 
ATOM   1821 O O   . SER B 2 195 ? 19.95382  -26.09453 32.63319  1.000 102.80315 ? 527 SER B O   1 
ATOM   1822 C CB  . SER B 2 195 ? 20.72009  -24.38677 29.86166  1.000 91.61881  ? 527 SER B CB  1 
ATOM   1823 N N   . ASN B 2 196 ? 20.61841  -23.96771 32.95927  1.000 98.37658  ? 528 ASN B N   1 
ATOM   1824 C CA  . ASN B 2 196 ? 21.17003  -24.20161 34.28922  1.000 94.03734  ? 528 ASN B CA  1 
ATOM   1825 C C   . ASN B 2 196 ? 20.15727  -23.92877 35.40042  1.000 98.69738  ? 528 ASN B C   1 
ATOM   1826 O O   . ASN B 2 196 ? 20.53607  -23.46960 36.48792  1.000 94.40619  ? 528 ASN B O   1 
ATOM   1827 C CB  . ASN B 2 196 ? 22.43121  -23.35444 34.48100  1.000 93.88938  ? 528 ASN B CB  1 
ATOM   1828 C CG  . ASN B 2 196 ? 23.29553  -23.83456 35.63598  1.000 95.47683  ? 528 ASN B CG  1 
ATOM   1829 O OD1 . ASN B 2 196 ? 23.45593  -23.13673 36.63826  1.000 90.75247  ? 528 ASN B OD1 1 
ATOM   1830 N ND2 . ASN B 2 196 ? 23.85259  -25.03278 35.50138  1.000 99.78202  ? 528 ASN B ND2 1 
ATOM   1831 N N   . SER B 2 197 ? 18.87800  -24.20108 35.15701  1.000 97.71768  ? 529 SER B N   1 
ATOM   1832 C CA  . SER B 2 197 ? 17.83795  -23.97285 36.15540  1.000 99.45418  ? 529 SER B CA  1 
ATOM   1833 C C   . SER B 2 197 ? 17.79282  -25.10663 37.17650  1.000 94.66975  ? 529 SER B C   1 
ATOM   1834 O O   . SER B 2 197 ? 18.40957  -25.02507 38.23949  1.000 92.21495  ? 529 SER B O   1 
ATOM   1835 C CB  . SER B 2 197 ? 16.47345  -23.81906 35.47965  1.000 94.37019  ? 529 SER B CB  1 
ATOM   1836 O OG  . SER B 2 197 ? 15.45204  -23.59424 36.43381  1.000 92.48969  ? 529 SER B OG  1 
ATOM   1837 N N   . ASP C 1 1   ? 7.17986   28.17245  14.33289  1.000 69.93563  ? 1   ASP C N   1 
ATOM   1838 C CA  . ASP C 1 1   ? 7.61658   29.38213  13.64512  1.000 69.77789  ? 1   ASP C CA  1 
ATOM   1839 C C   . ASP C 1 1   ? 7.93021   29.08269  12.18399  1.000 70.45756  ? 1   ASP C C   1 
ATOM   1840 O O   . ASP C 1 1   ? 8.29507   27.95540  11.83902  1.000 67.81920  ? 1   ASP C O   1 
ATOM   1841 C CB  . ASP C 1 1   ? 8.84625   29.97951  14.33728  1.000 70.10372  ? 1   ASP C CB  1 
ATOM   1842 C CG  . ASP C 1 1   ? 9.08296   31.43808  13.96468  1.000 79.99838  ? 1   ASP C CG  1 
ATOM   1843 O OD1 . ASP C 1 1   ? 8.68647   31.85425  12.85326  1.000 77.33211  ? 1   ASP C OD1 1 
ATOM   1844 O OD2 . ASP C 1 1   ? 9.67063   32.17070  14.79182  1.000 81.89451  ? 1   ASP C OD2 1 
ATOM   1845 N N   . LYS C 1 2   ? 7.78057   30.09614  11.32677  1.000 66.40412  ? 2   LYS C N   1 
ATOM   1846 C CA  . LYS C 1 2   ? 8.21346   29.94811  9.94334   1.000 61.08805  ? 2   LYS C CA  1 
ATOM   1847 C C   . LYS C 1 2   ? 9.73034   29.84087  9.85260   1.000 58.32522  ? 2   LYS C C   1 
ATOM   1848 O O   . LYS C 1 2   ? 10.24777  29.06169  9.04341   1.000 57.32066  ? 2   LYS C O   1 
ATOM   1849 C CB  . LYS C 1 2   ? 7.70223   31.11944  9.09644   1.000 57.68156  ? 2   LYS C CB  1 
ATOM   1850 C CG  . LYS C 1 2   ? 8.16448   31.07793  7.63915   1.000 69.76128  ? 2   LYS C CG  1 
ATOM   1851 C CD  . LYS C 1 2   ? 7.36360   32.00520  6.72338   1.000 73.19248  ? 2   LYS C CD  1 
ATOM   1852 C CE  . LYS C 1 2   ? 7.77500   31.80106  5.25991   1.000 65.19866  ? 2   LYS C CE  1 
ATOM   1853 N NZ  . LYS C 1 2   ? 6.92981   32.54777  4.28556   1.000 59.94078  ? 2   LYS C NZ  1 
ATOM   1854 N N   . LEU C 1 3   ? 10.45509  30.59272  10.68824  1.000 57.64223  ? 3   LEU C N   1 
ATOM   1855 C CA  . LEU C 1 3   ? 11.91277  30.51535  10.68526  1.000 57.37176  ? 3   LEU C CA  1 
ATOM   1856 C C   . LEU C 1 3   ? 12.40489  29.13029  11.08071  1.000 57.03810  ? 3   LEU C C   1 
ATOM   1857 O O   . LEU C 1 3   ? 13.44984  28.68303  10.59359  1.000 54.77572  ? 3   LEU C O   1 
ATOM   1858 C CB  . LEU C 1 3   ? 12.50694  31.56966  11.62046  1.000 52.05271  ? 3   LEU C CB  1 
ATOM   1859 C CG  . LEU C 1 3   ? 12.46408  33.03166  11.17292  1.000 67.47365  ? 3   LEU C CG  1 
ATOM   1860 C CD1 . LEU C 1 3   ? 12.84391  33.15095  9.70240   1.000 66.55289  ? 3   LEU C CD1 1 
ATOM   1861 C CD2 . LEU C 1 3   ? 11.10400  33.66375  11.44030  1.000 68.44970  ? 3   LEU C CD2 1 
ATOM   1862 N N   . TRP C 1 4   ? 11.68132  28.44076  11.96546  1.000 48.15976  ? 4   TRP C N   1 
ATOM   1863 C CA  . TRP C 1 4   ? 12.07244  27.07965  12.31590  1.000 51.84204  ? 4   TRP C CA  1 
ATOM   1864 C C   . TRP C 1 4   ? 11.84040  26.12820  11.14950  1.000 45.84473  ? 4   TRP C C   1 
ATOM   1865 O O   . TRP C 1 4   ? 12.68538  25.27325  10.85982  1.000 44.52445  ? 4   TRP C O   1 
ATOM   1866 C CB  . TRP C 1 4   ? 11.30936  26.60973  13.55558  1.000 48.83204  ? 4   TRP C CB  1 
ATOM   1867 C CG  . TRP C 1 4   ? 11.77361  25.27812  14.06752  1.000 48.47403  ? 4   TRP C CG  1 
ATOM   1868 C CD1 . TRP C 1 4   ? 12.73480  25.05079  15.01184  1.000 50.01197  ? 4   TRP C CD1 1 
ATOM   1869 C CD2 . TRP C 1 4   ? 11.30275  23.98840  13.65894  1.000 50.83635  ? 4   TRP C CD2 1 
ATOM   1870 N NE1 . TRP C 1 4   ? 12.89002  23.70065  15.21668  1.000 47.24921  ? 4   TRP C NE1 1 
ATOM   1871 C CE2 . TRP C 1 4   ? 12.02214  23.02649  14.39807  1.000 53.99872  ? 4   TRP C CE2 1 
ATOM   1872 C CE3 . TRP C 1 4   ? 10.34168  23.55266  12.74132  1.000 53.75743  ? 4   TRP C CE3 1 
ATOM   1873 C CZ2 . TRP C 1 4   ? 11.80958  21.65507  14.24595  1.000 53.49526  ? 4   TRP C CZ2 1 
ATOM   1874 C CZ3 . TRP C 1 4   ? 10.13299  22.19100  12.59263  1.000 51.31881  ? 4   TRP C CZ3 1 
ATOM   1875 C CH2 . TRP C 1 4   ? 10.86296  21.26005  13.34012  1.000 51.57118  ? 4   TRP C CH2 1 
ATOM   1876 N N   . ILE C 1 5   ? 10.69790  26.26210  10.47365  1.000 52.73196  ? 5   ILE C N   1 
ATOM   1877 C CA  . ILE C 1 5   ? 10.41416  25.43754  9.30163   1.000 49.03633  ? 5   ILE C CA  1 
ATOM   1878 C C   . ILE C 1 5   ? 11.45834  25.67762  8.22141   1.000 43.58023  ? 5   ILE C C   1 
ATOM   1879 O O   . ILE C 1 5   ? 12.03521  24.73286  7.67082   1.000 43.42483  ? 5   ILE C O   1 
ATOM   1880 C CB  . ILE C 1 5   ? 8.99777   25.72408  8.77455   1.000 53.47859  ? 5   ILE C CB  1 
ATOM   1881 C CG1 . ILE C 1 5   ? 7.95675   25.46080  9.85978   1.000 62.36078  ? 5   ILE C CG1 1 
ATOM   1882 C CG2 . ILE C 1 5   ? 8.71258   24.89094  7.53494   1.000 57.03703  ? 5   ILE C CG2 1 
ATOM   1883 C CD1 . ILE C 1 5   ? 6.57689   25.96845  9.50436   1.000 69.68561  ? 5   ILE C CD1 1 
ATOM   1884 N N   . LEU C 1 6   ? 11.70846  26.95091  7.89734   1.000 47.49177  ? 6   LEU C N   1 
ATOM   1885 C CA  . LEU C 1 6   ? 12.69321  27.28186  6.87166   1.000 44.76377  ? 6   LEU C CA  1 
ATOM   1886 C C   . LEU C 1 6   ? 14.05681  26.69205  7.20362   1.000 44.49605  ? 6   LEU C C   1 
ATOM   1887 O O   . LEU C 1 6   ? 14.73571  26.15029  6.32406   1.000 39.63672  ? 6   LEU C O   1 
ATOM   1888 C CB  . LEU C 1 6   ? 12.79060  28.79906  6.70393   1.000 48.47402  ? 6   LEU C CB  1 
ATOM   1889 C CG  . LEU C 1 6   ? 13.77307  29.29710  5.64120   1.000 49.08647  ? 6   LEU C CG  1 
ATOM   1890 C CD1 . LEU C 1 6   ? 13.36788  28.80019  4.26223   1.000 43.65539  ? 6   LEU C CD1 1 
ATOM   1891 C CD2 . LEU C 1 6   ? 13.87769  30.81617  5.65982   1.000 41.51538  ? 6   LEU C CD2 1 
ATOM   1892 N N   . GLN C 1 7   ? 14.46566  26.76329  8.47319   1.000 46.40533  ? 7   GLN C N   1 
ATOM   1893 C CA  . GLN C 1 7   ? 15.77133  26.23073  8.84819   1.000 42.08220  ? 7   GLN C CA  1 
ATOM   1894 C C   . GLN C 1 7   ? 15.83596  24.72233  8.64113   1.000 40.30189  ? 7   GLN C C   1 
ATOM   1895 O O   . GLN C 1 7   ? 16.82237  24.20959  8.09979   1.000 43.09038  ? 7   GLN C O   1 
ATOM   1896 C CB  . GLN C 1 7   ? 16.09690  26.59362  10.29757  1.000 43.34328  ? 7   GLN C CB  1 
ATOM   1897 C CG  . GLN C 1 7   ? 17.47820  26.12740  10.75591  1.000 43.01429  ? 7   GLN C CG  1 
ATOM   1898 C CD  . GLN C 1 7   ? 18.61654  26.77376  9.97338   1.000 49.03181  ? 7   GLN C CD  1 
ATOM   1899 O OE1 . GLN C 1 7   ? 18.48109  27.88688  9.46092   1.000 46.71952  ? 7   GLN C OE1 1 
ATOM   1900 N NE2 . GLN C 1 7   ? 19.74694  26.07378  9.88002   1.000 44.67509  ? 7   GLN C NE2 1 
ATOM   1901 N N   . LYS C 1 8   ? 14.79451  23.99388  9.05496   1.000 40.64075  ? 8   LYS C N   1 
ATOM   1902 C CA  . LYS C 1 8   ? 14.79272  22.54553  8.86019   1.000 40.24462  ? 8   LYS C CA  1 
ATOM   1903 C C   . LYS C 1 8   ? 14.78103  22.18660  7.38005   1.000 40.11531  ? 8   LYS C C   1 
ATOM   1904 O O   . LYS C 1 8   ? 15.43321  21.22146  6.96620   1.000 43.57794  ? 8   LYS C O   1 
ATOM   1905 C CB  . LYS C 1 8   ? 13.59938  21.91017  9.57297   1.000 42.36871  ? 8   LYS C CB  1 
ATOM   1906 C CG  . LYS C 1 8   ? 13.70839  21.91073  11.09069  1.000 51.29418  ? 8   LYS C CG  1 
ATOM   1907 C CD  . LYS C 1 8   ? 14.98786  21.22454  11.54448  1.000 51.24524  ? 8   LYS C CD  1 
ATOM   1908 C CE  . LYS C 1 8   ? 15.21160  21.39799  13.03422  1.000 55.96175  ? 8   LYS C CE  1 
ATOM   1909 N NZ  . LYS C 1 8   ? 16.58751  20.98979  13.42564  1.000 61.11610  ? 8   LYS C NZ  1 
ATOM   1910 N N   . ILE C 1 9   ? 14.04749  22.94848  6.56760   1.000 41.61675  ? 9   ILE C N   1 
ATOM   1911 C CA  . ILE C 1 9   ? 14.07505  22.71824  5.12775   1.000 38.91473  ? 9   ILE C CA  1 
ATOM   1912 C C   . ILE C 1 9   ? 15.47841  22.94878  4.58237   1.000 40.31503  ? 9   ILE C C   1 
ATOM   1913 O O   . ILE C 1 9   ? 16.00957  22.12278  3.83117   1.000 38.67330  ? 9   ILE C O   1 
ATOM   1914 C CB  . ILE C 1 9   ? 13.03682  23.60898  4.42520   1.000 42.68237  ? 9   ILE C CB  1 
ATOM   1915 C CG1 . ILE C 1 9   ? 11.63777  23.29139  4.93993   1.000 43.09098  ? 9   ILE C CG1 1 
ATOM   1916 C CG2 . ILE C 1 9   ? 13.05910  23.36878  2.93353   1.000 43.83090  ? 9   ILE C CG2 1 
ATOM   1917 C CD1 . ILE C 1 9   ? 11.20573  21.89242  4.62103   1.000 47.88423  ? 9   ILE C CD1 1 
ATOM   1918 N N   . TYR C 1 10  ? 16.11199  24.05928  4.97004   1.000 39.89169  ? 10  TYR C N   1 
ATOM   1919 C CA  . TYR C 1 10  ? 17.47570  24.31881  4.51980   1.000 40.93482  ? 10  TYR C CA  1 
ATOM   1920 C C   . TYR C 1 10  ? 18.41998  23.19617  4.93492   1.000 38.12357  ? 10  TYR C C   1 
ATOM   1921 O O   . TYR C 1 10  ? 19.23983  22.73942  4.12922   1.000 39.25836  ? 10  TYR C O   1 
ATOM   1922 C CB  . TYR C 1 10  ? 17.96642  25.66091  5.06362   1.000 43.01591  ? 10  TYR C CB  1 
ATOM   1923 C CG  . TYR C 1 10  ? 19.32644  26.07066  4.53667   1.000 48.76714  ? 10  TYR C CG  1 
ATOM   1924 C CD1 . TYR C 1 10  ? 19.44989  26.75012  3.32534   1.000 41.60354  ? 10  TYR C CD1 1 
ATOM   1925 C CD2 . TYR C 1 10  ? 20.48924  25.77129  5.24461   1.000 41.37801  ? 10  TYR C CD2 1 
ATOM   1926 C CE1 . TYR C 1 10  ? 20.69085  27.11958  2.83797   1.000 38.89936  ? 10  TYR C CE1 1 
ATOM   1927 C CE2 . TYR C 1 10  ? 21.73318  26.13618  4.76283   1.000 41.66250  ? 10  TYR C CE2 1 
ATOM   1928 C CZ  . TYR C 1 10  ? 21.82676  26.80895  3.55948   1.000 45.42431  ? 10  TYR C CZ  1 
ATOM   1929 O OH  . TYR C 1 10  ? 23.06359  27.17436  3.07818   1.000 49.44472  ? 10  TYR C OH  1 
ATOM   1930 N N   . GLU C 1 11  ? 18.30284  22.72016  6.17779   1.000 38.91344  ? 11  GLU C N   1 
ATOM   1931 C CA  . GLU C 1 11  ? 19.22091  21.69457  6.66250   1.000 40.43719  ? 11  GLU C CA  1 
ATOM   1932 C C   . GLU C 1 11  ? 19.04752  20.38247  5.90681   1.000 36.72139  ? 11  GLU C C   1 
ATOM   1933 O O   . GLU C 1 11  ? 20.03181  19.68178  5.64697   1.000 39.01821  ? 11  GLU C O   1 
ATOM   1934 C CB  . GLU C 1 11  ? 19.03245  21.48594  8.16622   1.000 37.49119  ? 11  GLU C CB  1 
ATOM   1935 C CG  . GLU C 1 11  ? 19.51455  22.65997  8.99086   1.000 44.78225  ? 11  GLU C CG  1 
ATOM   1936 C CD  . GLU C 1 11  ? 19.21207  22.51613  10.47062  1.000 50.13877  ? 11  GLU C CD  1 
ATOM   1937 O OE1 . GLU C 1 11  ? 18.82382  21.41159  10.90920  1.000 53.26743  ? 11  GLU C OE1 1 
ATOM   1938 O OE2 . GLU C 1 11  ? 19.36144  23.51929  11.19747  1.000 50.30329  ? 11  GLU C OE2 1 
ATOM   1939 N N   . ILE C 1 12  ? 17.81275  20.02441  5.54378   1.000 32.42076  ? 12  ILE C N   1 
ATOM   1940 C CA  . ILE C 1 12  ? 17.64578  18.78105  4.79771   1.000 35.54946  ? 12  ILE C CA  1 
ATOM   1941 C C   . ILE C 1 12  ? 18.12324  18.94958  3.35876   1.000 37.21455  ? 12  ILE C C   1 
ATOM   1942 O O   . ILE C 1 12  ? 18.61382  17.99192  2.74931   1.000 35.33675  ? 12  ILE C O   1 
ATOM   1943 C CB  . ILE C 1 12  ? 16.19245  18.27210  4.86660   1.000 38.17732  ? 12  ILE C CB  1 
ATOM   1944 C CG1 . ILE C 1 12  ? 16.14869  16.79489  4.46654   1.000 37.20216  ? 12  ILE C CG1 1 
ATOM   1945 C CG2 . ILE C 1 12  ? 15.26800  19.08478  3.96583   1.000 34.95988  ? 12  ILE C CG2 1 
ATOM   1946 C CD1 . ILE C 1 12  ? 14.78187  16.15672  4.57502   1.000 38.89113  ? 12  ILE C CD1 1 
ATOM   1947 N N   . MET C 1 13  ? 18.01607  20.15788  2.79706   1.000 36.65567  ? 13  MET C N   1 
ATOM   1948 C CA  . MET C 1 13  ? 18.62091  20.40596  1.49179   1.000 36.73621  ? 13  MET C CA  1 
ATOM   1949 C C   . MET C 1 13  ? 20.11535  20.10604  1.52222   1.000 40.76978  ? 13  MET C C   1 
ATOM   1950 O O   . MET C 1 13  ? 20.63890  19.42559  0.63143   1.000 35.58834  ? 13  MET C O   1 
ATOM   1951 C CB  . MET C 1 13  ? 18.37396  21.85151  1.05386   1.000 33.47557  ? 13  MET C CB  1 
ATOM   1952 C CG  . MET C 1 13  ? 18.95918  22.19174  -0.32407  1.000 36.85506  ? 13  MET C CG  1 
ATOM   1953 S SD  . MET C 1 13  ? 18.75497  23.92261  -0.81620  1.000 40.23561  ? 13  MET C SD  1 
ATOM   1954 C CE  . MET C 1 13  ? 19.80153  24.76030  0.36607   1.000 40.49096  ? 13  MET C CE  1 
ATOM   1955 N N   . VAL C 1 14  ? 20.81377  20.58846  2.55541   1.000 40.22799  ? 14  VAL C N   1 
ATOM   1956 C CA  . VAL C 1 14  ? 22.25101  20.35311  2.66549   1.000 41.68424  ? 14  VAL C CA  1 
ATOM   1957 C C   . VAL C 1 14  ? 22.53689  18.87911  2.92357   1.000 41.67734  ? 14  VAL C C   1 
ATOM   1958 O O   . VAL C 1 14  ? 23.44906  18.29491  2.32439   1.000 42.01227  ? 14  VAL C O   1 
ATOM   1959 C CB  . VAL C 1 14  ? 22.85554  21.24877  3.76224   1.000 45.73646  ? 14  VAL C CB  1 
ATOM   1960 C CG1 . VAL C 1 14  ? 24.32168  20.91435  3.96742   1.000 39.93968  ? 14  VAL C CG1 1 
ATOM   1961 C CG2 . VAL C 1 14  ? 22.68027  22.71399  3.39880   1.000 38.97983  ? 14  VAL C CG2 1 
ATOM   1962 N N   . ARG C 1 15  ? 21.75948  18.25228  3.80882   1.000 42.23711  ? 15  ARG C N   1 
ATOM   1963 C CA  . ARG C 1 15  ? 21.99657  16.85092  4.14442   1.000 42.94027  ? 15  ARG C CA  1 
ATOM   1964 C C   . ARG C 1 15  ? 21.74540  15.94381  2.94774   1.000 41.09017  ? 15  ARG C C   1 
ATOM   1965 O O   . ARG C 1 15  ? 22.51959  15.01391  2.69535   1.000 43.68169  ? 15  ARG C O   1 
ATOM   1966 C CB  . ARG C 1 15  ? 21.11512  16.44071  5.32416   1.000 42.65739  ? 15  ARG C CB  1 
ATOM   1967 C CG  . ARG C 1 15  ? 21.46576  15.09233  5.93345   1.000 56.65330  ? 15  ARG C CG  1 
ATOM   1968 C CD  . ARG C 1 15  ? 20.91159  14.98022  7.34788   1.000 62.37532  ? 15  ARG C CD  1 
ATOM   1969 N NE  . ARG C 1 15  ? 21.35843  13.76419  8.01876   1.000 78.06074  ? 15  ARG C NE  1 
ATOM   1970 C CZ  . ARG C 1 15  ? 20.62017  12.67224  8.16310   1.000 74.08912  ? 15  ARG C CZ  1 
ATOM   1971 N NH1 . ARG C 1 15  ? 19.38083  12.61083  7.70173   1.000 71.32727  ? 15  ARG C NH1 1 
ATOM   1972 N NH2 . ARG C 1 15  ? 21.13681  11.61764  8.78977   1.000 71.00217  ? 15  ARG C NH2 1 
ATOM   1973 N N   . LEU C 1 16  ? 20.66504  16.19510  2.20327   1.000 39.90401  ? 16  LEU C N   1 
ATOM   1974 C CA  . LEU C 1 16  ? 20.38304  15.39676  1.01400   1.000 41.60750  ? 16  LEU C CA  1 
ATOM   1975 C C   . LEU C 1 16  ? 21.53259  15.46221  0.01995   1.000 38.60713  ? 16  LEU C C   1 
ATOM   1976 O O   . LEU C 1 16  ? 21.92447  14.44074  -0.55797  1.000 42.75941  ? 16  LEU C O   1 
ATOM   1977 C CB  . LEU C 1 16  ? 19.08527  15.86901  0.36116   1.000 36.14005  ? 16  LEU C CB  1 
ATOM   1978 C CG  . LEU C 1 16  ? 17.79609  15.40992  1.04309   1.000 40.88898  ? 16  LEU C CG  1 
ATOM   1979 C CD1 . LEU C 1 16  ? 16.60346  16.13388  0.45483   1.000 36.60138  ? 16  LEU C CD1 1 
ATOM   1980 C CD2 . LEU C 1 16  ? 17.63374  13.90431  0.90925   1.000 38.07237  ? 16  LEU C CD2 1 
ATOM   1981 N N   . ASP C 1 17  ? 22.09141  16.65454  -0.18799  1.000 41.09850  ? 17  ASP C N   1 
ATOM   1982 C CA  . ASP C 1 17  ? 23.19839  16.78551  -1.12794  1.000 41.55148  ? 17  ASP C CA  1 
ATOM   1983 C C   . ASP C 1 17  ? 24.45275  16.09721  -0.60466  1.000 44.77442  ? 17  ASP C C   1 
ATOM   1984 O O   . ASP C 1 17  ? 25.14644  15.40296  -1.35724  1.000 40.04077  ? 17  ASP C O   1 
ATOM   1985 C CB  . ASP C 1 17  ? 23.47754  18.25916  -1.41362  1.000 42.07657  ? 17  ASP C CB  1 
ATOM   1986 C CG  . ASP C 1 17  ? 24.73571  18.45783  -2.23163  1.000 44.80345  ? 17  ASP C CG  1 
ATOM   1987 O OD1 . ASP C 1 17  ? 24.69668  18.22881  -3.46141  1.000 43.60664  ? 17  ASP C OD1 1 
ATOM   1988 O OD2 . ASP C 1 17  ? 25.76858  18.83195  -1.63878  1.000 45.16407  ? 17  ASP C OD2 1 
ATOM   1989 N N   . GLU C 1 18  ? 24.75564  16.26902  0.68429   1.000 40.96269  ? 18  GLU C N   1 
ATOM   1990 C CA  . GLU C 1 18  ? 25.95918  15.66046  1.24050   1.000 40.81699  ? 18  GLU C CA  1 
ATOM   1991 C C   . GLU C 1 18  ? 25.92311  14.13916  1.15777   1.000 39.77207  ? 18  GLU C C   1 
ATOM   1992 O O   . GLU C 1 18  ? 26.97169  13.50661  0.99285   1.000 45.35520  ? 18  GLU C O   1 
ATOM   1993 C CB  . GLU C 1 18  ? 26.15822  16.11829  2.68526   1.000 42.51170  ? 18  GLU C CB  1 
ATOM   1994 C CG  . GLU C 1 18  ? 26.62683  17.55955  2.78031   1.000 52.59478  ? 18  GLU C CG  1 
ATOM   1995 C CD  . GLU C 1 18  ? 26.74854  18.05624  4.20796   1.000 64.89623  ? 18  GLU C CD  1 
ATOM   1996 O OE1 . GLU C 1 18  ? 26.33144  17.32835  5.13784   1.000 68.17879  ? 18  GLU C OE1 1 
ATOM   1997 O OE2 . GLU C 1 18  ? 27.26113  19.18158  4.39562   1.000 65.55236  ? 18  GLU C OE2 1 
ATOM   1998 N N   . GLU C 1 19  ? 24.74150  13.53078  1.23851   1.000 38.26333  ? 19  GLU C N   1 
ATOM   1999 C CA  . GLU C 1 19  ? 24.63677  12.07821  1.20974   1.000 42.20350  ? 19  GLU C CA  1 
ATOM   2000 C C   . GLU C 1 19  ? 24.36788  11.53250  -0.19190  1.000 45.39303  ? 19  GLU C C   1 
ATOM   2001 O O   . GLU C 1 19  ? 23.95439  10.37592  -0.33512  1.000 42.39095  ? 19  GLU C O   1 
ATOM   2002 C CB  . GLU C 1 19  ? 23.56708  11.61084  2.19855   1.000 41.73850  ? 19  GLU C CB  1 
ATOM   2003 C CG  . GLU C 1 19  ? 23.93584  11.92090  3.65109   1.000 50.21299  ? 19  GLU C CG  1 
ATOM   2004 C CD  . GLU C 1 19  ? 22.98738  11.29445  4.65866   1.000 63.57493  ? 19  GLU C CD  1 
ATOM   2005 O OE1 . GLU C 1 19  ? 22.19596  10.40464  4.27108   1.000 63.14386  ? 19  GLU C OE1 1 
ATOM   2006 O OE2 . GLU C 1 19  ? 23.03756  11.69588  5.84245   1.000 62.34848  ? 19  GLU C OE2 1 
ATOM   2007 N N   . GLY C 1 20  ? 24.61204  12.33084  -1.22672  1.000 42.20269  ? 20  GLY C N   1 
ATOM   2008 C CA  . GLY C 1 20  ? 24.50787  11.84168  -2.58537  1.000 42.86725  ? 20  GLY C CA  1 
ATOM   2009 C C   . GLY C 1 20  ? 23.12409  11.86067  -3.18733  1.000 43.97143  ? 20  GLY C C   1 
ATOM   2010 O O   . GLY C 1 20  ? 22.84876  11.07157  -4.09909  1.000 42.90153  ? 20  GLY C O   1 
ATOM   2011 N N   . HIS C 1 21  ? 22.24118  12.73303  -2.71398  1.000 43.58828  ? 21  HIS C N   1 
ATOM   2012 C CA  . HIS C 1 21  ? 20.88558  12.84894  -3.24819  1.000 41.21456  ? 21  HIS C CA  1 
ATOM   2013 C C   . HIS C 1 21  ? 20.70067  14.25986  -3.80444  1.000 37.83582  ? 21  HIS C C   1 
ATOM   2014 O O   . HIS C 1 21  ? 19.87916  15.03597  -3.30540  1.000 39.43083  ? 21  HIS C O   1 
ATOM   2015 C CB  . HIS C 1 21  ? 19.84486  12.51717  -2.16938  1.000 35.95865  ? 21  HIS C CB  1 
ATOM   2016 C CG  . HIS C 1 21  ? 20.11459  11.23187  -1.45226  1.000 43.09221  ? 21  HIS C CG  1 
ATOM   2017 N ND1 . HIS C 1 21  ? 20.11623  10.01071  -2.09140  1.000 40.27365  ? 21  HIS C ND1 1 
ATOM   2018 C CD2 . HIS C 1 21  ? 20.39901  10.97733  -0.15255  1.000 39.04902  ? 21  HIS C CD2 1 
ATOM   2019 C CE1 . HIS C 1 21  ? 20.38604  9.05885   -1.21677  1.000 41.84268  ? 21  HIS C CE1 1 
ATOM   2020 N NE2 . HIS C 1 21  ? 20.56200  9.61872   -0.03302  1.000 40.85089  ? 21  HIS C NE2 1 
ATOM   2021 N N   . GLY C 1 22  ? 21.47515  14.59127  -4.84122  1.000 45.30287  ? 22  GLY C N   1 
ATOM   2022 C CA  . GLY C 1 22  ? 21.44611  15.94580  -5.37183  1.000 39.48006  ? 22  GLY C CA  1 
ATOM   2023 C C   . GLY C 1 22  ? 20.11034  16.31996  -5.98824  1.000 36.19123  ? 22  GLY C C   1 
ATOM   2024 O O   . GLY C 1 22  ? 19.61109  17.42675  -5.77145  1.000 33.10869  ? 22  GLY C O   1 
ATOM   2025 N N   . GLU C 1 23  ? 19.51436  15.41051  -6.76788  1.000 36.12548  ? 23  GLU C N   1 
ATOM   2026 C CA  . GLU C 1 23  ? 18.21525  15.70428  -7.37128  1.000 40.62118  ? 23  GLU C CA  1 
ATOM   2027 C C   . GLU C 1 23  ? 17.17123  16.01009  -6.30463  1.000 39.75777  ? 23  GLU C C   1 
ATOM   2028 O O   . GLU C 1 23  ? 16.41943  16.98425  -6.42534  1.000 37.17796  ? 23  GLU C O   1 
ATOM   2029 C CB  . GLU C 1 23  ? 17.76987  14.54636  -8.26705  1.000 34.03644  ? 23  GLU C CB  1 
ATOM   2030 C CG  . GLU C 1 23  ? 18.50396  14.52252  -9.60667  1.000 41.57679  ? 23  GLU C CG  1 
ATOM   2031 C CD  . GLU C 1 23  ? 18.02648  13.42086  -10.53440 1.000 43.33775  ? 23  GLU C CD  1 
ATOM   2032 O OE1 . GLU C 1 23  ? 18.37972  12.24459  -10.30130 1.000 43.80130  ? 23  GLU C OE1 1 
ATOM   2033 O OE2 . GLU C 1 23  ? 17.29204  13.73512  -11.49624 1.000 45.41072  ? 23  GLU C OE2 1 
ATOM   2034 N N   . ALA C 1 24  ? 17.12983  15.20759  -5.23787  1.000 35.89505  ? 24  ALA C N   1 
ATOM   2035 C CA  . ALA C 1 24  ? 16.25836  15.52443  -4.11047  1.000 35.86061  ? 24  ALA C CA  1 
ATOM   2036 C C   . ALA C 1 24  ? 16.58876  16.89228  -3.52545  1.000 34.79375  ? 24  ALA C C   1 
ATOM   2037 O O   . ALA C 1 24  ? 15.68697  17.69050  -3.24041  1.000 35.06655  ? 24  ALA C O   1 
ATOM   2038 C CB  . ALA C 1 24  ? 16.37891  14.44359  -3.03839  1.000 31.84180  ? 24  ALA C CB  1 
ATOM   2039 N N   . SER C 1 25  ? 17.88127  17.17807  -3.34251  1.000 35.73886  ? 25  SER C N   1 
ATOM   2040 C CA  . SER C 1 25  ? 18.29708  18.46868  -2.80199  1.000 34.59728  ? 25  SER C CA  1 
ATOM   2041 C C   . SER C 1 25  ? 17.80608  19.62005  -3.67491  1.000 34.40585  ? 25  SER C C   1 
ATOM   2042 O O   . SER C 1 25  ? 17.35056  20.64899  -3.16134  1.000 35.88368  ? 25  SER C O   1 
ATOM   2043 C CB  . SER C 1 25  ? 19.82208  18.50018  -2.66385  1.000 37.32656  ? 25  SER C CB  1 
ATOM   2044 O OG  . SER C 1 25  ? 20.26141  19.65799  -1.97707  1.000 35.38141  ? 25  SER C OG  1 
ATOM   2045 N N   . LEU C 1 26  ? 17.87792  19.46046  -4.99915  1.000 33.94716  ? 26  LEU C N   1 
ATOM   2046 C CA  . LEU C 1 26  ? 17.39129  20.50518  -5.89856  1.000 37.02461  ? 26  LEU C CA  1 
ATOM   2047 C C   . LEU C 1 26  ? 15.88500  20.69989  -5.76254  1.000 36.65634  ? 26  LEU C C   1 
ATOM   2048 O O   . LEU C 1 26  ? 15.39157  21.83373  -5.82850  1.000 32.03087  ? 26  LEU C O   1 
ATOM   2049 C CB  . LEU C 1 26  ? 17.76362  20.16960  -7.34352  1.000 35.67930  ? 26  LEU C CB  1 
ATOM   2050 C CG  . LEU C 1 26  ? 19.25919  20.23645  -7.66442  1.000 34.93634  ? 26  LEU C CG  1 
ATOM   2051 C CD1 . LEU C 1 26  ? 19.54835  19.66968  -9.04238  1.000 34.76699  ? 26  LEU C CD1 1 
ATOM   2052 C CD2 . LEU C 1 26  ? 19.75926  21.66976  -7.55585  1.000 35.34557  ? 26  LEU C CD2 1 
ATOM   2053 N N   . MET C 1 27  ? 15.13980  19.60644  -5.57248  1.000 30.20205  ? 27  MET C N   1 
ATOM   2054 C CA  . MET C 1 27  ? 13.70245  19.72185  -5.34464  1.000 36.57743  ? 27  MET C CA  1 
ATOM   2055 C C   . MET C 1 27  ? 13.40899  20.52237  -4.08415  1.000 35.43801  ? 27  MET C C   1 
ATOM   2056 O O   . MET C 1 27  ? 12.45787  21.31181  -4.04758  1.000 35.95025  ? 27  MET C O   1 
ATOM   2057 C CB  . MET C 1 27  ? 13.06248  18.33748  -5.23983  1.000 36.75135  ? 27  MET C CB  1 
ATOM   2058 C CG  . MET C 1 27  ? 13.10182  17.50863  -6.49924  1.000 46.62017  ? 27  MET C CG  1 
ATOM   2059 S SD  . MET C 1 27  ? 12.38388  15.87944  -6.20144  1.000 51.64420  ? 27  MET C SD  1 
ATOM   2060 C CE  . MET C 1 27  ? 10.96268  16.33382  -5.22336  1.000 41.38680  ? 27  MET C CE  1 
ATOM   2061 N N   . VAL C 1 28  ? 14.20517  20.32100  -3.03338  1.000 34.34609  ? 28  VAL C N   1 
ATOM   2062 C CA  . VAL C 1 28  ? 13.99250  21.07004  -1.79982  1.000 31.92586  ? 28  VAL C CA  1 
ATOM   2063 C C   . VAL C 1 28  ? 14.36206  22.53490  -1.99974  1.000 35.05381  ? 28  VAL C C   1 
ATOM   2064 O O   . VAL C 1 28  ? 13.67701  23.43567  -1.49932  1.000 35.89684  ? 28  VAL C O   1 
ATOM   2065 C CB  . VAL C 1 28  ? 14.78460  20.42872  -0.64614  1.000 35.40996  ? 28  VAL C CB  1 
ATOM   2066 C CG1 . VAL C 1 28  ? 14.62957  21.24178  0.61915   1.000 31.98339  ? 28  VAL C CG1 1 
ATOM   2067 C CG2 . VAL C 1 28  ? 14.31907  19.00032  -0.41732  1.000 29.00396  ? 28  VAL C CG2 1 
ATOM   2068 N N   . SER C 1 29  ? 15.45278  22.79465  -2.73001  1.000 35.36460  ? 29  SER C N   1 
ATOM   2069 C CA  . SER C 1 29  ? 15.80310  24.16470  -3.09499  1.000 32.74035  ? 29  SER C CA  1 
ATOM   2070 C C   . SER C 1 29  ? 14.60907  24.89939  -3.69612  1.000 36.00155  ? 29  SER C C   1 
ATOM   2071 O O   . SER C 1 29  ? 14.27364  26.01052  -3.26792  1.000 33.58350  ? 29  SER C O   1 
ATOM   2072 C CB  . SER C 1 29  ? 16.97565  24.15503  -4.07687  1.000 37.25984  ? 29  SER C CB  1 
ATOM   2073 O OG  . SER C 1 29  ? 17.27917  25.46208  -4.53990  1.000 39.34547  ? 29  SER C OG  1 
ATOM   2074 N N   . ASP C 1 30  ? 13.94514  24.28583  -4.68046  1.000 31.15563  ? 30  ASP C N   1 
ATOM   2075 C CA  . ASP C 1 30  ? 12.75046  24.89305  -5.26409  1.000 36.64009  ? 30  ASP C CA  1 
ATOM   2076 C C   . ASP C 1 30  ? 11.69817  25.19299  -4.20194  1.000 38.62148  ? 30  ASP C C   1 
ATOM   2077 O O   . ASP C 1 30  ? 11.04309  26.24193  -4.24589  1.000 35.09811  ? 30  ASP C O   1 
ATOM   2078 C CB  . ASP C 1 30  ? 12.16625  23.98146  -6.34222  1.000 31.96588  ? 30  ASP C CB  1 
ATOM   2079 C CG  . ASP C 1 30  ? 13.08391  23.82837  -7.53882  1.000 38.95892  ? 30  ASP C CG  1 
ATOM   2080 O OD1 . ASP C 1 30  ? 13.93137  24.72191  -7.76952  1.000 38.26203  ? 30  ASP C OD1 1 
ATOM   2081 O OD2 . ASP C 1 30  ? 12.95266  22.81257  -8.25358  1.000 40.56774  ? 30  ASP C OD2 1 
ATOM   2082 N N   . LEU C 1 31  ? 11.51591  24.28311  -3.24126  1.000 34.69077  ? 31  LEU C N   1 
ATOM   2083 C CA  . LEU C 1 31  ? 10.55193  24.53753  -2.17570  1.000 35.54898  ? 31  LEU C CA  1 
ATOM   2084 C C   . LEU C 1 31  ? 10.96618  25.74064  -1.33838  1.000 37.52291  ? 31  LEU C C   1 
ATOM   2085 O O   . LEU C 1 31  ? 10.11624  26.54757  -0.94034  1.000 38.11568  ? 31  LEU C O   1 
ATOM   2086 C CB  . LEU C 1 31  ? 10.38719  23.29811  -1.29346  1.000 37.10043  ? 31  LEU C CB  1 
ATOM   2087 C CG  . LEU C 1 31  ? 9.42258   23.44028  -0.10875  1.000 37.75393  ? 31  LEU C CG  1 
ATOM   2088 C CD1 . LEU C 1 31  ? 8.06589   23.96773  -0.56070  1.000 37.95579  ? 31  LEU C CD1 1 
ATOM   2089 C CD2 . LEU C 1 31  ? 9.26447   22.11846  0.62435   1.000 35.75340  ? 31  LEU C CD2 1 
ATOM   2090 N N   . ILE C 1 32  ? 12.26807  25.88503  -1.07315  1.000 36.06495  ? 32  ILE C N   1 
ATOM   2091 C CA  . ILE C 1 32  ? 12.75002  27.04182  -0.32209  1.000 35.74830  ? 32  ILE C CA  1 
ATOM   2092 C C   . ILE C 1 32  ? 12.37728  28.33376  -1.03438  1.000 37.22254  ? 32  ILE C C   1 
ATOM   2093 O O   . ILE C 1 32  ? 11.90605  29.28960  -0.40677  1.000 39.03472  ? 32  ILE C O   1 
ATOM   2094 C CB  . ILE C 1 32  ? 14.26892  26.94449  -0.09247  1.000 37.94591  ? 32  ILE C CB  1 
ATOM   2095 C CG1 . ILE C 1 32  ? 14.58958  25.81499  0.88476   1.000 32.60395  ? 32  ILE C CG1 1 
ATOM   2096 C CG2 . ILE C 1 32  ? 14.82029  28.27069  0.41805   1.000 30.01685  ? 32  ILE C CG2 1 
ATOM   2097 C CD1 . ILE C 1 32  ? 16.06463  25.66916  1.17296   1.000 34.98412  ? 32  ILE C CD1 1 
ATOM   2098 N N   . TYR C 1 33  ? 12.58123  28.38735  -2.35420  1.000 39.25282  ? 33  TYR C N   1 
ATOM   2099 C CA  . TYR C 1 33  ? 12.18888  29.57507  -3.10678  1.000 35.56726  ? 33  TYR C CA  1 
ATOM   2100 C C   . TYR C 1 33  ? 10.69099  29.82240  -2.99412  1.000 42.51583  ? 33  TYR C C   1 
ATOM   2101 O O   . TYR C 1 33  ? 10.25670  30.94654  -2.72128  1.000 43.94888  ? 33  TYR C O   1 
ATOM   2102 C CB  . TYR C 1 33  ? 12.59279  29.44435  -4.57721  1.000 37.72254  ? 33  TYR C CB  1 
ATOM   2103 C CG  . TYR C 1 33  ? 11.85066  30.41498  -5.47716  1.000 33.82958  ? 33  TYR C CG  1 
ATOM   2104 C CD1 . TYR C 1 33  ? 12.25088  31.74301  -5.57956  1.000 37.75348  ? 33  TYR C CD1 1 
ATOM   2105 C CD2 . TYR C 1 33  ? 10.73850  30.00948  -6.20901  1.000 38.05993  ? 33  TYR C CD2 1 
ATOM   2106 C CE1 . TYR C 1 33  ? 11.57221  32.63672  -6.38926  1.000 39.57366  ? 33  TYR C CE1 1 
ATOM   2107 C CE2 . TYR C 1 33  ? 10.05091  30.89970  -7.02222  1.000 39.42576  ? 33  TYR C CE2 1 
ATOM   2108 C CZ  . TYR C 1 33  ? 10.47498  32.20971  -7.10765  1.000 37.25541  ? 33  TYR C CZ  1 
ATOM   2109 O OH  . TYR C 1 33  ? 9.79594   33.09652  -7.91011  1.000 45.15672  ? 33  TYR C OH  1 
ATOM   2110 N N   . GLU C 1 34  ? 9.88236   28.78111  -3.21248  1.000 37.64888  ? 34  GLU C N   1 
ATOM   2111 C CA  . GLU C 1 34  ? 8.43468   28.96678  -3.22288  1.000 44.44873  ? 34  GLU C CA  1 
ATOM   2112 C C   . GLU C 1 34  ? 7.91533   29.33612  -1.83816  1.000 49.26237  ? 34  GLU C C   1 
ATOM   2113 O O   . GLU C 1 34  ? 7.03647   30.19668  -1.71033  1.000 49.29558  ? 34  GLU C O   1 
ATOM   2114 C CB  . GLU C 1 34  ? 7.74050   27.70563  -3.74797  1.000 45.21159  ? 34  GLU C CB  1 
ATOM   2115 C CG  . GLU C 1 34  ? 6.22637   27.85335  -3.91524  1.000 58.10015  ? 34  GLU C CG  1 
ATOM   2116 C CD  . GLU C 1 34  ? 5.57139   26.65391  -4.59555  1.000 73.02895  ? 34  GLU C CD  1 
ATOM   2117 O OE1 . GLU C 1 34  ? 6.27076   25.64712  -4.85703  1.000 71.66016  ? 34  GLU C OE1 1 
ATOM   2118 O OE2 . GLU C 1 34  ? 4.35146   26.72626  -4.87078  1.000 66.59987  ? 34  GLU C OE2 1 
ATOM   2119 N N   . PHE C 1 35  ? 8.46119   28.70879  -0.79110  1.000 44.48448  ? 35  PHE C N   1 
ATOM   2120 C CA  . PHE C 1 35  ? 7.99954   28.96285  0.57266   1.000 45.65187  ? 35  PHE C CA  1 
ATOM   2121 C C   . PHE C 1 35  ? 8.28960   30.39641  1.00131   1.000 48.04478  ? 35  PHE C C   1 
ATOM   2122 O O   . PHE C 1 35  ? 7.43060   31.05600  1.59765   1.000 49.32168  ? 35  PHE C O   1 
ATOM   2123 C CB  . PHE C 1 35  ? 8.65595   27.95828  1.52535   1.000 42.58129  ? 35  PHE C CB  1 
ATOM   2124 C CG  . PHE C 1 35  ? 8.21766   28.07691  2.96001   1.000 46.58934  ? 35  PHE C CG  1 
ATOM   2125 C CD1 . PHE C 1 35  ? 6.88013   27.95892  3.31041   1.000 47.88155  ? 35  PHE C CD1 1 
ATOM   2126 C CD2 . PHE C 1 35  ? 9.15417   28.25887  3.96452   1.000 46.34939  ? 35  PHE C CD2 1 
ATOM   2127 C CE1 . PHE C 1 35  ? 6.48398   28.05040  4.63357   1.000 52.69710  ? 35  PHE C CE1 1 
ATOM   2128 C CE2 . PHE C 1 35  ? 8.76603   28.35060  5.28737   1.000 57.45044  ? 35  PHE C CE2 1 
ATOM   2129 C CZ  . PHE C 1 35  ? 7.42725   28.24554  5.62257   1.000 55.45536  ? 35  PHE C CZ  1 
ATOM   2130 N N   . MET C 1 36  ? 9.48751   30.90073  0.69382   1.000 48.25198  ? 36  MET C N   1 
ATOM   2131 C CA  . MET C 1 36  ? 9.87414   32.24728  1.09947   1.000 48.49936  ? 36  MET C CA  1 
ATOM   2132 C C   . MET C 1 36  ? 9.17325   33.33480  0.29852   1.000 49.59286  ? 36  MET C C   1 
ATOM   2133 O O   . MET C 1 36  ? 9.22556   34.50164  0.69855   1.000 50.76005  ? 36  MET C O   1 
ATOM   2134 C CB  . MET C 1 36  ? 11.38934  32.41413  0.98594   1.000 44.90494  ? 36  MET C CB  1 
ATOM   2135 C CG  . MET C 1 36  ? 12.15807  31.48326  1.90185   1.000 48.41492  ? 36  MET C CG  1 
ATOM   2136 S SD  . MET C 1 36  ? 13.93182  31.75918  1.87171   1.000 49.09302  ? 36  MET C SD  1 
ATOM   2137 C CE  . MET C 1 36  ? 14.03116  33.39851  2.58215   1.000 43.10817  ? 36  MET C CE  1 
ATOM   2138 N N   . LYS C 1 37  ? 8.52430   32.98874  -0.81334  1.000 54.91026  ? 37  LYS C N   1 
ATOM   2139 C CA  . LYS C 1 37  ? 7.71933   33.95635  -1.54652  1.000 53.97136  ? 37  LYS C CA  1 
ATOM   2140 C C   . LYS C 1 37  ? 6.35681   34.18172  -0.90800  1.000 57.16436  ? 37  LYS C C   1 
ATOM   2141 O O   . LYS C 1 37  ? 5.75475   35.23850  -1.12158  1.000 64.77267  ? 37  LYS C O   1 
ATOM   2142 C CB  . LYS C 1 37  ? 7.53459   33.50327  -2.99680  1.000 52.06794  ? 37  LYS C CB  1 
ATOM   2143 C CG  . LYS C 1 37  ? 8.72673   33.78651  -3.89522  1.000 50.60997  ? 37  LYS C CG  1 
ATOM   2144 C CD  . LYS C 1 37  ? 8.90755   35.28124  -4.09713  1.000 50.53271  ? 37  LYS C CD  1 
ATOM   2145 C CE  . LYS C 1 37  ? 10.02235  35.57055  -5.08454  1.000 52.21360  ? 37  LYS C CE  1 
ATOM   2146 N NZ  . LYS C 1 37  ? 10.12573  37.02210  -5.39106  1.000 56.99885  ? 37  LYS C NZ  1 
ATOM   2147 N N   . ARG C 1 38  ? 5.85877   33.22178  -0.13543  1.000 58.96468  ? 38  ARG C N   1 
ATOM   2148 C CA  . ARG C 1 38  ? 4.55539   33.37547  0.49167   1.000 69.17174  ? 38  ARG C CA  1 
ATOM   2149 C C   . ARG C 1 38  ? 4.63370   34.34654  1.66192   1.000 71.38890  ? 38  ARG C C   1 
ATOM   2150 O O   . ARG C 1 38  ? 5.66138   34.46633  2.33517   1.000 73.50589  ? 38  ARG C O   1 
ATOM   2151 C CB  . ARG C 1 38  ? 4.02490   32.02482  0.96636   1.000 61.62077  ? 38  ARG C CB  1 
ATOM   2152 C CG  . ARG C 1 38  ? 3.80948   31.02743  -0.15406  1.000 60.75854  ? 38  ARG C CG  1 
ATOM   2153 C CD  . ARG C 1 38  ? 3.31040   29.70039  0.38210   1.000 61.70514  ? 38  ARG C CD  1 
ATOM   2154 N NE  . ARG C 1 38  ? 1.91991   29.76169  0.81633   1.000 67.33492  ? 38  ARG C NE  1 
ATOM   2155 C CZ  . ARG C 1 38  ? 0.87950   29.60300  0.00945   1.000 62.74613  ? 38  ARG C CZ  1 
ATOM   2156 N NH1 . ARG C 1 38  ? 1.03630   29.40996  -1.28961  1.000 61.71432  ? 38  ARG C NH1 1 
ATOM   2157 N NH2 . ARG C 1 38  ? -0.34866  29.63620  0.51904   1.000 70.91072  ? 38  ARG C NH2 1 
ATOM   2158 N N   . ASP C 1 39  ? 3.52624   35.04118  1.89926   1.000 80.28422  ? 39  ASP C N   1 
ATOM   2159 C CA  . ASP C 1 39  ? 3.46002   36.05921  2.93949   1.000 87.29434  ? 39  ASP C CA  1 
ATOM   2160 C C   . ASP C 1 39  ? 3.53733   35.43949  4.32921   1.000 90.45519  ? 39  ASP C C   1 
ATOM   2161 O O   . ASP C 1 39  ? 3.78832   36.13328  5.31493   1.000 99.19633  ? 39  ASP C O   1 
ATOM   2162 C CB  . ASP C 1 39  ? 2.17634   36.87770  2.79988   1.000 86.85921  ? 39  ASP C CB  1 
ATOM   2163 C CG  . ASP C 1 39  ? 1.98427   37.42283  1.39737   1.000 98.65044  ? 39  ASP C CG  1 
ATOM   2164 O OD1 . ASP C 1 39  ? 2.99800   37.66518  0.70559   1.000 96.29461  ? 39  ASP C OD1 1 
ATOM   2165 O OD2 . ASP C 1 39  ? 0.81939   37.60680  0.98508   1.000 105.18283 ? 39  ASP C OD2 1 
ATOM   2166 O OXT . ASP C 1 39  ? 3.35255   34.23377  4.49930   1.000 95.22962  ? 39  ASP C OXT 1 
ATOM   2167 N N   . THR D 2 1   ? 32.32005  43.58078  -43.73536 1.000 76.36187  ? 333 THR D N   1 
ATOM   2168 C CA  . THR D 2 1   ? 33.00228  42.40207  -44.25655 1.000 88.14602  ? 333 THR D CA  1 
ATOM   2169 C C   . THR D 2 1   ? 33.32294  41.40576  -43.14307 1.000 83.72006  ? 333 THR D C   1 
ATOM   2170 O O   . THR D 2 1   ? 33.37546  40.19594  -43.37624 1.000 84.46994  ? 333 THR D O   1 
ATOM   2171 C CB  . THR D 2 1   ? 34.30668  42.78113  -44.98820 1.000 86.50210  ? 333 THR D CB  1 
ATOM   2172 O OG1 . THR D 2 1   ? 35.11503  43.60616  -44.13823 1.000 79.36836  ? 333 THR D OG1 1 
ATOM   2173 C CG2 . THR D 2 1   ? 33.99789  43.52804  -46.27818 1.000 86.64467  ? 333 THR D CG2 1 
ATOM   2174 N N   . ASN D 2 2   ? 33.53649  41.91981  -41.93437 1.000 73.42249  ? 334 ASN D N   1 
ATOM   2175 C CA  . ASN D 2 2   ? 33.85140  41.05922  -40.80243 1.000 76.23210  ? 334 ASN D CA  1 
ATOM   2176 C C   . ASN D 2 2   ? 32.63331  40.24594  -40.38444 1.000 69.49632  ? 334 ASN D C   1 
ATOM   2177 O O   . ASN D 2 2   ? 31.50970  40.75426  -40.34288 1.000 60.47624  ? 334 ASN D O   1 
ATOM   2178 C CB  . ASN D 2 2   ? 34.34843  41.88981  -39.62160 1.000 77.37258  ? 334 ASN D CB  1 
ATOM   2179 C CG  . ASN D 2 2   ? 35.67765  42.55154  -39.89817 1.000 88.34457  ? 334 ASN D CG  1 
ATOM   2180 O OD1 . ASN D 2 2   ? 36.47755  42.05337  -40.69043 1.000 86.44746  ? 334 ASN D OD1 1 
ATOM   2181 N ND2 . ASN D 2 2   ? 35.92319  43.68251  -39.24593 1.000 91.03752  ? 334 ASN D ND2 1 
ATOM   2182 N N   . LEU D 2 3   ? 32.86318  38.97219  -40.07555 1.000 68.41722  ? 335 LEU D N   1 
ATOM   2183 C CA  . LEU D 2 3   ? 31.81098  38.09247  -39.58665 1.000 66.91373  ? 335 LEU D CA  1 
ATOM   2184 C C   . LEU D 2 3   ? 31.65643  38.26211  -38.08321 1.000 57.81932  ? 335 LEU D C   1 
ATOM   2185 O O   . LEU D 2 3   ? 32.64740  38.38127  -37.35714 1.000 53.64949  ? 335 LEU D O   1 
ATOM   2186 C CB  . LEU D 2 3   ? 32.12051  36.63212  -39.92083 1.000 60.91298  ? 335 LEU D CB  1 
ATOM   2187 C CG  . LEU D 2 3   ? 31.46039  36.08344  -41.18625 1.000 73.53809  ? 335 LEU D CG  1 
ATOM   2188 C CD1 . LEU D 2 3   ? 29.95578  35.99786  -40.99499 1.000 72.42849  ? 335 LEU D CD1 1 
ATOM   2189 C CD2 . LEU D 2 3   ? 31.79664  36.94195  -42.40091 1.000 72.75996  ? 335 LEU D CD2 1 
ATOM   2190 N N   . CYS D 2 4   ? 30.40854  38.28304  -37.62166 1.000 58.38872  ? 336 CYS D N   1 
ATOM   2191 C CA  . CYS D 2 4   ? 30.16341  38.44283  -36.19477 1.000 58.94584  ? 336 CYS D CA  1 
ATOM   2192 C C   . CYS D 2 4   ? 30.64004  37.20068  -35.44471 1.000 53.90118  ? 336 CYS D C   1 
ATOM   2193 O O   . CYS D 2 4   ? 30.42444  36.07489  -35.90554 1.000 54.53463  ? 336 CYS D O   1 
ATOM   2194 C CB  . CYS D 2 4   ? 28.67850  38.69518  -35.91727 1.000 57.20742  ? 336 CYS D CB  1 
ATOM   2195 S SG  . CYS D 2 4   ? 28.02914  40.25696  -36.61595 1.000 58.52883  ? 336 CYS D SG  1 
ATOM   2196 N N   . PRO D 2 5   ? 31.29794  37.37074  -34.29551 1.000 53.08628  ? 337 PRO D N   1 
ATOM   2197 C CA  . PRO D 2 5   ? 31.88246  36.22987  -33.56528 1.000 52.18501  ? 337 PRO D CA  1 
ATOM   2198 C C   . PRO D 2 5   ? 30.84511  35.42500  -32.78729 1.000 50.97038  ? 337 PRO D C   1 
ATOM   2199 O O   . PRO D 2 5   ? 30.94098  35.24163  -31.56953 1.000 54.19612  ? 337 PRO D O   1 
ATOM   2200 C CB  . PRO D 2 5   ? 32.89790  36.91998  -32.64619 1.000 51.81555  ? 337 PRO D CB  1 
ATOM   2201 C CG  . PRO D 2 5   ? 32.30374  38.25792  -32.38466 1.000 48.58590  ? 337 PRO D CG  1 
ATOM   2202 C CD  . PRO D 2 5   ? 31.62279  38.66067  -33.66295 1.000 49.89073  ? 337 PRO D CD  1 
ATOM   2203 N N   . PHE D 2 6   ? 29.83748  34.92261  -33.50199 1.000 49.92890  ? 338 PHE D N   1 
ATOM   2204 C CA  . PHE D 2 6   ? 28.81454  34.10578  -32.86142 1.000 58.09599  ? 338 PHE D CA  1 
ATOM   2205 C C   . PHE D 2 6   ? 29.31690  32.70097  -32.55032 1.000 59.50330  ? 338 PHE D C   1 
ATOM   2206 O O   . PHE D 2 6   ? 28.89169  32.10520  -31.55343 1.000 59.28478  ? 338 PHE D O   1 
ATOM   2207 C CB  . PHE D 2 6   ? 27.56067  34.05056  -33.73716 1.000 54.21460  ? 338 PHE D CB  1 
ATOM   2208 C CG  . PHE D 2 6   ? 26.67272  35.25721  -33.59560 1.000 61.66117  ? 338 PHE D CG  1 
ATOM   2209 C CD1 . PHE D 2 6   ? 26.60732  35.94548  -32.39257 1.000 55.78420  ? 338 PHE D CD1 1 
ATOM   2210 C CD2 . PHE D 2 6   ? 25.90831  35.70643  -34.66142 1.000 63.30293  ? 338 PHE D CD2 1 
ATOM   2211 C CE1 . PHE D 2 6   ? 25.79537  37.05707  -32.25348 1.000 56.64593  ? 338 PHE D CE1 1 
ATOM   2212 C CE2 . PHE D 2 6   ? 25.09474  36.81803  -34.52956 1.000 61.17727  ? 338 PHE D CE2 1 
ATOM   2213 C CZ  . PHE D 2 6   ? 25.03854  37.49421  -33.32285 1.000 56.16854  ? 338 PHE D CZ  1 
ATOM   2214 N N   . ASP D 2 7   ? 30.21576  32.15961  -33.37734 1.000 58.26475  ? 339 ASP D N   1 
ATOM   2215 C CA  . ASP D 2 7   ? 30.83660  30.87957  -33.05042 1.000 57.83467  ? 339 ASP D CA  1 
ATOM   2216 C C   . ASP D 2 7   ? 31.55183  30.93568  -31.70663 1.000 53.92221  ? 339 ASP D C   1 
ATOM   2217 O O   . ASP D 2 7   ? 31.55027  29.95152  -30.95860 1.000 58.94285  ? 339 ASP D O   1 
ATOM   2218 C CB  . ASP D 2 7   ? 31.81146  30.47007  -34.15710 1.000 62.31532  ? 339 ASP D CB  1 
ATOM   2219 C CG  . ASP D 2 7   ? 32.61875  29.23377  -33.79711 1.000 70.05518  ? 339 ASP D CG  1 
ATOM   2220 O OD1 . ASP D 2 7   ? 32.06555  28.11718  -33.88358 1.000 74.68245  ? 339 ASP D OD1 1 
ATOM   2221 O OD2 . ASP D 2 7   ? 33.80279  29.37822  -33.41755 1.000 68.75204  ? 339 ASP D OD2 1 
ATOM   2222 N N   . GLU D 2 8   ? 32.16229  32.07667  -31.38282 1.000 52.96535  ? 340 GLU D N   1 
ATOM   2223 C CA  . GLU D 2 8   ? 32.81169  32.23339  -30.08755 1.000 50.68013  ? 340 GLU D CA  1 
ATOM   2224 C C   . GLU D 2 8   ? 31.80269  32.18315  -28.94501 1.000 57.27490  ? 340 GLU D C   1 
ATOM   2225 O O   . GLU D 2 8   ? 32.14524  31.77375  -27.82976 1.000 56.02238  ? 340 GLU D O   1 
ATOM   2226 C CB  . GLU D 2 8   ? 33.59272  33.54789  -30.06646 1.000 54.09796  ? 340 GLU D CB  1 
ATOM   2227 C CG  . GLU D 2 8   ? 34.13926  33.95033  -28.70414 1.000 68.36090  ? 340 GLU D CG  1 
ATOM   2228 C CD  . GLU D 2 8   ? 34.70173  35.36142  -28.69810 1.000 80.55754  ? 340 GLU D CD  1 
ATOM   2229 O OE1 . GLU D 2 8   ? 34.98961  35.89077  -29.79432 1.000 75.68931  ? 340 GLU D OE1 1 
ATOM   2230 O OE2 . GLU D 2 8   ? 34.84963  35.94259  -27.59973 1.000 89.61274  ? 340 GLU D OE2 1 
ATOM   2231 N N   . VAL D 2 9   ? 30.55644  32.57911  -29.20353 1.000 53.81709  ? 341 VAL D N   1 
ATOM   2232 C CA  . VAL D 2 9   ? 29.53978  32.59477  -28.15616 1.000 50.98610  ? 341 VAL D CA  1 
ATOM   2233 C C   . VAL D 2 9   ? 28.94252  31.20828  -27.95754 1.000 51.34674  ? 341 VAL D C   1 
ATOM   2234 O O   . VAL D 2 9   ? 28.95744  30.66071  -26.84874 1.000 50.48062  ? 341 VAL D O   1 
ATOM   2235 C CB  . VAL D 2 9   ? 28.44751  33.62781  -28.48994 1.000 57.36968  ? 341 VAL D CB  1 
ATOM   2236 C CG1 . VAL D 2 9   ? 27.36318  33.61983  -27.42203 1.000 48.39600  ? 341 VAL D CG1 1 
ATOM   2237 C CG2 . VAL D 2 9   ? 29.05449  35.01854  -28.63751 1.000 54.34228  ? 341 VAL D CG2 1 
ATOM   2238 N N   . PHE D 2 10  ? 28.41229  30.62097  -29.03103 1.000 49.97766  ? 342 PHE D N   1 
ATOM   2239 C CA  . PHE D 2 10  ? 27.66009  29.37664  -28.90827 1.000 51.76771  ? 342 PHE D CA  1 
ATOM   2240 C C   . PHE D 2 10  ? 28.57335  28.18339  -28.66215 1.000 55.92052  ? 342 PHE D C   1 
ATOM   2241 O O   . PHE D 2 10  ? 28.22594  27.27722  -27.89432 1.000 53.73307  ? 342 PHE D O   1 
ATOM   2242 C CB  . PHE D 2 10  ? 26.82085  29.15389  -30.16330 1.000 49.64255  ? 342 PHE D CB  1 
ATOM   2243 C CG  . PHE D 2 10  ? 25.68496  30.11764  -30.30290 1.000 55.74370  ? 342 PHE D CG  1 
ATOM   2244 C CD1 . PHE D 2 10  ? 25.88025  31.36212  -30.87767 1.000 54.79649  ? 342 PHE D CD1 1 
ATOM   2245 C CD2 . PHE D 2 10  ? 24.41859  29.78229  -29.85147 1.000 53.72492  ? 342 PHE D CD2 1 
ATOM   2246 C CE1 . PHE D 2 10  ? 24.83322  32.25222  -31.00382 1.000 55.31382  ? 342 PHE D CE1 1 
ATOM   2247 C CE2 . PHE D 2 10  ? 23.36648  30.66725  -29.97397 1.000 50.07202  ? 342 PHE D CE2 1 
ATOM   2248 C CZ  . PHE D 2 10  ? 23.57345  31.90434  -30.55113 1.000 48.28126  ? 342 PHE D CZ  1 
ATOM   2249 N N   . ASN D 2 11  ? 29.74193  28.16003  -29.29967 1.000 50.71146  ? 343 ASN D N   1 
ATOM   2250 C CA  . ASN D 2 11  ? 30.63199  27.01095  -29.22933 1.000 52.23308  ? 343 ASN D CA  1 
ATOM   2251 C C   . ASN D 2 11  ? 31.77268  27.21254  -28.23840 1.000 53.26228  ? 343 ASN D C   1 
ATOM   2252 O O   . ASN D 2 11  ? 32.78247  26.50494  -28.31520 1.000 57.33739  ? 343 ASN D O   1 
ATOM   2253 C CB  . ASN D 2 11  ? 31.17738  26.68111  -30.62177 1.000 55.79255  ? 343 ASN D CB  1 
ATOM   2254 C CG  . ASN D 2 11  ? 30.08180  26.26152  -31.59487 1.000 59.27696  ? 343 ASN D CG  1 
ATOM   2255 O OD1 . ASN D 2 11  ? 29.04629  25.73436  -31.18744 1.000 62.47758  ? 343 ASN D OD1 1 
ATOM   2256 N ND2 . ASN D 2 11  ? 30.30718  26.49424  -32.88593 1.000 64.73338  ? 343 ASN D ND2 1 
ATOM   2257 N N   . ALA D 2 12  ? 31.63117  28.15556  -27.31016 1.000 49.49242  ? 344 ALA D N   1 
ATOM   2258 C CA  . ALA D 2 12  ? 32.64490  28.35734  -26.28609 1.000 49.20138  ? 344 ALA D CA  1 
ATOM   2259 C C   . ALA D 2 12  ? 32.79896  27.10378  -25.43394 1.000 56.97009  ? 344 ALA D C   1 
ATOM   2260 O O   . ALA D 2 12  ? 31.85582  26.32985  -25.24845 1.000 53.89378  ? 344 ALA D O   1 
ATOM   2261 C CB  . ALA D 2 12  ? 32.28803  29.54988  -25.39935 1.000 40.57950  ? 344 ALA D CB  1 
ATOM   2262 N N   . THR D 2 13  ? 34.00955  26.90691  -24.91087 1.000 55.68730  ? 345 THR D N   1 
ATOM   2263 C CA  . THR D 2 13  ? 34.28559  25.69745  -24.14360 1.000 56.87450  ? 345 THR D CA  1 
ATOM   2264 C C   . THR D 2 13  ? 33.61116  25.74723  -22.77807 1.000 57.38418  ? 345 THR D C   1 
ATOM   2265 O O   . THR D 2 13  ? 32.98908  24.76934  -22.34744 1.000 54.32753  ? 345 THR D O   1 
ATOM   2266 C CB  . THR D 2 13  ? 35.79460  25.49713  -24.00391 1.000 58.82171  ? 345 THR D CB  1 
ATOM   2267 O OG1 . THR D 2 13  ? 36.36490  25.30155  -25.30408 1.000 61.83427  ? 345 THR D OG1 1 
ATOM   2268 C CG2 . THR D 2 13  ? 36.09626  24.27845  -23.14507 1.000 56.07067  ? 345 THR D CG2 1 
ATOM   2269 N N   . ARG D 2 14  ? 33.70819  26.88228  -22.08877 1.000 57.22674  ? 346 ARG D N   1 
ATOM   2270 C CA  . ARG D 2 14  ? 33.14264  27.04636  -20.75693 1.000 55.93106  ? 346 ARG D CA  1 
ATOM   2271 C C   . ARG D 2 14  ? 32.10056  28.15973  -20.76773 1.000 56.13856  ? 346 ARG D C   1 
ATOM   2272 O O   . ARG D 2 14  ? 32.24641  29.15127  -21.48887 1.000 52.78411  ? 346 ARG D O   1 
ATOM   2273 C CB  . ARG D 2 14  ? 34.25279  27.34698  -19.73991 1.000 61.56133  ? 346 ARG D CB  1 
ATOM   2274 C CG  . ARG D 2 14  ? 35.61591  26.80576  -20.16854 1.000 73.45160  ? 346 ARG D CG  1 
ATOM   2275 C CD  . ARG D 2 14  ? 36.58539  26.64603  -19.00437 1.000 82.62921  ? 346 ARG D CD  1 
ATOM   2276 N NE  . ARG D 2 14  ? 36.20524  25.55313  -18.11659 1.000 87.27621  ? 346 ARG D NE  1 
ATOM   2277 C CZ  . ARG D 2 14  ? 37.02027  24.98038  -17.24100 1.000 94.52902  ? 346 ARG D CZ  1 
ATOM   2278 N NH1 . ARG D 2 14  ? 38.28420  25.35638  -17.12460 1.000 92.99613  ? 346 ARG D NH1 1 
ATOM   2279 N NH2 . ARG D 2 14  ? 36.55686  24.00237  -16.46639 1.000 89.26927  ? 346 ARG D NH2 1 
ATOM   2280 N N   . PHE D 2 15  ? 31.03831  27.98056  -19.98585 1.000 49.12575  ? 347 PHE D N   1 
ATOM   2281 C CA  . PHE D 2 15  ? 29.97980  28.96920  -19.83750 1.000 39.61345  ? 347 PHE D CA  1 
ATOM   2282 C C   . PHE D 2 15  ? 29.97063  29.50836  -18.41311 1.000 39.87054  ? 347 PHE D C   1 
ATOM   2283 O O   . PHE D 2 15  ? 30.55486  28.92232  -17.49912 1.000 40.29168  ? 347 PHE D O   1 
ATOM   2284 C CB  . PHE D 2 15  ? 28.60798  28.37323  -20.18159 1.000 38.07226  ? 347 PHE D CB  1 
ATOM   2285 C CG  . PHE D 2 15  ? 28.19792  28.56090  -21.62187 1.000 40.33018  ? 347 PHE D CG  1 
ATOM   2286 C CD1 . PHE D 2 15  ? 29.06312  28.23724  -22.65569 1.000 42.07712  ? 347 PHE D CD1 1 
ATOM   2287 C CD2 . PHE D 2 15  ? 26.93269  29.03838  -21.93934 1.000 40.02484  ? 347 PHE D CD2 1 
ATOM   2288 C CE1 . PHE D 2 15  ? 28.68221  28.40103  -23.98299 1.000 43.84397  ? 347 PHE D CE1 1 
ATOM   2289 C CE2 . PHE D 2 15  ? 26.53965  29.20165  -23.26571 1.000 42.74748  ? 347 PHE D CE2 1 
ATOM   2290 C CZ  . PHE D 2 15  ? 27.41860  28.88327  -24.28989 1.000 37.57786  ? 347 PHE D CZ  1 
ATOM   2291 N N   . ALA D 2 16  ? 29.29860  30.63816  -18.23131 1.000 37.58922  ? 348 ALA D N   1 
ATOM   2292 C CA  . ALA D 2 16  ? 29.23568  31.28506  -16.93023 1.000 38.99197  ? 348 ALA D CA  1 
ATOM   2293 C C   . ALA D 2 16  ? 28.07324  30.74125  -16.10661 1.000 37.57357  ? 348 ALA D C   1 
ATOM   2294 O O   . ALA D 2 16  ? 27.09826  30.20681  -16.63913 1.000 37.16391  ? 348 ALA D O   1 
ATOM   2295 C CB  . ALA D 2 16  ? 29.08865  32.79956  -17.08641 1.000 37.31669  ? 348 ALA D CB  1 
ATOM   2296 N N   . SER D 2 17  ? 28.19698  30.87517  -14.78775 1.000 38.05181  ? 349 SER D N   1 
ATOM   2297 C CA  . SER D 2 17  ? 27.06942  30.62829  -13.90193 1.000 39.85720  ? 349 SER D CA  1 
ATOM   2298 C C   . SER D 2 17  ? 25.99050  31.66965  -14.15133 1.000 39.31623  ? 349 SER D C   1 
ATOM   2299 O O   . SER D 2 17  ? 26.27826  32.80882  -14.52775 1.000 41.44247  ? 349 SER D O   1 
ATOM   2300 C CB  . SER D 2 17  ? 27.50449  30.67614  -12.43678 1.000 39.44947  ? 349 SER D CB  1 
ATOM   2301 O OG  . SER D 2 17  ? 28.38233  29.60886  -12.12580 1.000 44.26494  ? 349 SER D OG  1 
ATOM   2302 N N   . VAL D 2 18  ? 24.73481  31.27213  -13.93149 1.000 35.90968  ? 350 VAL D N   1 
ATOM   2303 C CA  . VAL D 2 18  ? 23.62495  32.15860  -14.26599 1.000 35.05905  ? 350 VAL D CA  1 
ATOM   2304 C C   . VAL D 2 18  ? 23.62587  33.40635  -13.38636 1.000 35.40314  ? 350 VAL D C   1 
ATOM   2305 O O   . VAL D 2 18  ? 23.30090  34.50042  -13.86141 1.000 36.75116  ? 350 VAL D O   1 
ATOM   2306 C CB  . VAL D 2 18  ? 22.28775  31.39525  -14.18983 1.000 36.09785  ? 350 VAL D CB  1 
ATOM   2307 C CG1 . VAL D 2 18  ? 22.01454  30.90439  -12.77248 1.000 33.60779  ? 350 VAL D CG1 1 
ATOM   2308 C CG2 . VAL D 2 18  ? 21.14534  32.26181  -14.70165 1.000 35.00375  ? 350 VAL D CG2 1 
ATOM   2309 N N   . TYR D 2 19  ? 24.00195  33.28557  -12.10739 1.000 40.76861  ? 351 TYR D N   1 
ATOM   2310 C CA  . TYR D 2 19  ? 24.03164  34.47240  -11.25735 1.000 33.85605  ? 351 TYR D CA  1 
ATOM   2311 C C   . TYR D 2 19  ? 25.06719  35.47452  -11.74606 1.000 40.68304  ? 351 TYR D C   1 
ATOM   2312 O O   . TYR D 2 19  ? 24.88175  36.68514  -11.57793 1.000 41.22248  ? 351 TYR D O   1 
ATOM   2313 C CB  . TYR D 2 19  ? 24.30453  34.09048  -9.79896  1.000 37.87535  ? 351 TYR D CB  1 
ATOM   2314 C CG  . TYR D 2 19  ? 25.77047  33.93993  -9.45728  1.000 37.30242  ? 351 TYR D CG  1 
ATOM   2315 C CD1 . TYR D 2 19  ? 26.43101  32.74061  -9.67073  1.000 37.25602  ? 351 TYR D CD1 1 
ATOM   2316 C CD2 . TYR D 2 19  ? 26.49284  35.00008  -8.92111  1.000 42.61187  ? 351 TYR D CD2 1 
ATOM   2317 C CE1 . TYR D 2 19  ? 27.77197  32.60155  -9.36810  1.000 44.90494  ? 351 TYR D CE1 1 
ATOM   2318 C CE2 . TYR D 2 19  ? 27.83551  34.87100  -8.61551  1.000 41.71137  ? 351 TYR D CE2 1 
ATOM   2319 C CZ  . TYR D 2 19  ? 28.46963  33.66863  -8.84018  1.000 47.09452  ? 351 TYR D CZ  1 
ATOM   2320 O OH  . TYR D 2 19  ? 29.80431  33.52560  -8.53677  1.000 49.90747  ? 351 TYR D OH  1 
ATOM   2321 N N   . ALA D 2 20  ? 26.15242  34.98876  -12.35157 1.000 39.50657  ? 352 ALA D N   1 
ATOM   2322 C CA  . ALA D 2 20  ? 27.19604  35.83601  -12.91367 1.000 40.09064  ? 352 ALA D CA  1 
ATOM   2323 C C   . ALA D 2 20  ? 27.18383  35.74618  -14.43277 1.000 38.96444  ? 352 ALA D C   1 
ATOM   2324 O O   . ALA D 2 20  ? 28.23836  35.57134  -15.05399 1.000 35.77732  ? 352 ALA D O   1 
ATOM   2325 C CB  . ALA D 2 20  ? 28.56681  35.42566  -12.36989 1.000 37.46548  ? 352 ALA D CB  1 
ATOM   2326 N N   . TRP D 2 21  ? 25.99708  35.86110  -15.03153 1.000 36.68341  ? 353 TRP D N   1 
ATOM   2327 C CA  . TRP D 2 21  ? 25.83541  35.58970  -16.45534 1.000 39.31065  ? 353 TRP D CA  1 
ATOM   2328 C C   . TRP D 2 21  ? 26.72096  36.49918  -17.30095 1.000 41.91091  ? 353 TRP D C   1 
ATOM   2329 O O   . TRP D 2 21  ? 26.89184  37.68590  -17.00805 1.000 38.79185  ? 353 TRP D O   1 
ATOM   2330 C CB  . TRP D 2 21  ? 24.36907  35.74809  -16.86398 1.000 38.30587  ? 353 TRP D CB  1 
ATOM   2331 C CG  . TRP D 2 21  ? 23.73142  37.04111  -16.43494 1.000 39.25600  ? 353 TRP D CG  1 
ATOM   2332 C CD1 . TRP D 2 21  ? 23.11456  37.29455  -15.24374 1.000 37.93233  ? 353 TRP D CD1 1 
ATOM   2333 C CD2 . TRP D 2 21  ? 23.62435  38.24611  -17.20405 1.000 43.72287  ? 353 TRP D CD2 1 
ATOM   2334 N NE1 . TRP D 2 21  ? 22.63509  38.58180  -15.22004 1.000 37.66068  ? 353 TRP D NE1 1 
ATOM   2335 C CE2 . TRP D 2 21  ? 22.93625  39.18872  -16.41022 1.000 41.39432  ? 353 TRP D CE2 1 
ATOM   2336 C CE3 . TRP D 2 21  ? 24.04581  38.62167  -18.48545 1.000 43.42739  ? 353 TRP D CE3 1 
ATOM   2337 C CZ2 . TRP D 2 21  ? 22.66185  40.48380  -16.85378 1.000 42.05717  ? 353 TRP D CZ2 1 
ATOM   2338 C CZ3 . TRP D 2 21  ? 23.77164  39.90938  -18.92542 1.000 45.93565  ? 353 TRP D CZ3 1 
ATOM   2339 C CH2 . TRP D 2 21  ? 23.08574  40.82417  -18.11155 1.000 43.44737  ? 353 TRP D CH2 1 
ATOM   2340 N N   . ASN D 2 22  ? 27.29250  35.92645  -18.35434 1.000 39.62872  ? 354 ASN D N   1 
ATOM   2341 C CA  . ASN D 2 22  ? 28.22575  36.64507  -19.20638 1.000 46.62025  ? 354 ASN D CA  1 
ATOM   2342 C C   . ASN D 2 22  ? 27.48547  37.39997  -20.29961 1.000 46.90899  ? 354 ASN D C   1 
ATOM   2343 O O   . ASN D 2 22  ? 26.52348  36.89127  -20.88101 1.000 44.69379  ? 354 ASN D O   1 
ATOM   2344 C CB  . ASN D 2 22  ? 29.23264  35.68428  -19.83841 1.000 40.42370  ? 354 ASN D CB  1 
ATOM   2345 C CG  . ASN D 2 22  ? 30.23018  36.39782  -20.72730 1.000 55.09018  ? 354 ASN D CG  1 
ATOM   2346 O OD1 . ASN D 2 22  ? 30.06764  36.45658  -21.94924 1.000 50.05579  ? 354 ASN D OD1 1 
ATOM   2347 N ND2 . ASN D 2 22  ? 31.26149  36.96596  -20.11346 1.000 56.34197  ? 354 ASN D ND2 1 
ATOM   2348 N N   . ARG D 2 23  ? 27.94648  38.61586  -20.58122 1.000 47.74216  ? 355 ARG D N   1 
ATOM   2349 C CA  . ARG D 2 23  ? 27.42570  39.41543  -21.68137 1.000 44.64142  ? 355 ARG D CA  1 
ATOM   2350 C C   . ARG D 2 23  ? 28.54834  39.74190  -22.65394 1.000 44.21165  ? 355 ARG D C   1 
ATOM   2351 O O   . ARG D 2 23  ? 29.60325  40.24429  -22.24951 1.000 44.69187  ? 355 ARG D O   1 
ATOM   2352 C CB  . ARG D 2 23  ? 26.77847  40.70744  -21.18419 1.000 40.63447  ? 355 ARG D CB  1 
ATOM   2353 C CG  . ARG D 2 23  ? 26.56581  41.71725  -22.29283 1.000 41.85348  ? 355 ARG D CG  1 
ATOM   2354 C CD  . ARG D 2 23  ? 25.57046  42.78055  -21.89395 1.000 44.12381  ? 355 ARG D CD  1 
ATOM   2355 N NE  . ARG D 2 23  ? 24.20769  42.26729  -21.89166 1.000 45.19552  ? 355 ARG D NE  1 
ATOM   2356 C CZ  . ARG D 2 23  ? 23.12924  43.01429  -21.70694 1.000 46.02983  ? 355 ARG D CZ  1 
ATOM   2357 N NH1 . ARG D 2 23  ? 23.22091  44.31968  -21.49825 1.000 47.28826  ? 355 ARG D NH1 1 
ATOM   2358 N NH2 . ARG D 2 23  ? 21.92976  42.43839  -21.73598 1.000 40.28584  ? 355 ARG D NH2 1 
ATOM   2359 N N   . LYS D 2 24  ? 28.31523  39.45400  -23.93074 1.000 42.92567  ? 356 LYS D N   1 
ATOM   2360 C CA  . LYS D 2 24  ? 29.23315  39.79612  -25.00941 1.000 47.94026  ? 356 LYS D CA  1 
ATOM   2361 C C   . LYS D 2 24  ? 28.53979  40.78962  -25.93027 1.000 49.03055  ? 356 LYS D C   1 
ATOM   2362 O O   . LYS D 2 24  ? 27.45327  40.50564  -26.44608 1.000 44.28776  ? 356 LYS D O   1 
ATOM   2363 C CB  . LYS D 2 24  ? 29.66402  38.54716  -25.78423 1.000 45.33313  ? 356 LYS D CB  1 
ATOM   2364 C CG  . LYS D 2 24  ? 30.51546  38.83195  -27.01741 1.000 51.62813  ? 356 LYS D CG  1 
ATOM   2365 C CD  . LYS D 2 24  ? 31.75035  39.64328  -26.66418 1.000 59.72963  ? 356 LYS D CD  1 
ATOM   2366 C CE  . LYS D 2 24  ? 32.53664  40.03129  -27.91045 1.000 66.36146  ? 356 LYS D CE  1 
ATOM   2367 N NZ  . LYS D 2 24  ? 33.14462  38.84970  -28.58284 1.000 71.34656  ? 356 LYS D NZ  1 
ATOM   2368 N N   . ARG D 2 25  ? 29.16031  41.95120  -26.12698 1.000 51.17110  ? 357 ARG D N   1 
ATOM   2369 C CA  . ARG D 2 25  ? 28.64553  42.95916  -27.04499 1.000 51.93057  ? 357 ARG D CA  1 
ATOM   2370 C C   . ARG D 2 25  ? 29.17857  42.69412  -28.44806 1.000 49.53283  ? 357 ARG D C   1 
ATOM   2371 O O   . ARG D 2 25  ? 30.39230  42.57546  -28.64523 1.000 50.93112  ? 357 ARG D O   1 
ATOM   2372 C CB  . ARG D 2 25  ? 29.03486  44.36588  -26.58760 1.000 45.17810  ? 357 ARG D CB  1 
ATOM   2373 C CG  . ARG D 2 25  ? 28.39030  45.47838  -27.40366 1.000 52.97262  ? 357 ARG D CG  1 
ATOM   2374 C CD  . ARG D 2 25  ? 28.76253  46.85460  -26.86972 1.000 58.86207  ? 357 ARG D CD  1 
ATOM   2375 N NE  . ARG D 2 25  ? 30.17108  47.14993  -27.09776 1.000 64.95110  ? 357 ARG D NE  1 
ATOM   2376 C CZ  . ARG D 2 25  ? 30.65424  47.65782  -28.22310 1.000 67.92973  ? 357 ARG D CZ  1 
ATOM   2377 N NH1 . ARG D 2 25  ? 29.86265  47.97053  -29.23624 1.000 64.52261  ? 357 ARG D NH1 1 
ATOM   2378 N NH2 . ARG D 2 25  ? 31.96455  47.85310  -28.33631 1.000 72.61955  ? 357 ARG D NH2 1 
ATOM   2379 N N   . ILE D 2 26  ? 28.26655  42.59800  -29.41389 1.000 47.30554  ? 358 ILE D N   1 
ATOM   2380 C CA  . ILE D 2 26  ? 28.59221  42.33095  -30.81107 1.000 50.04541  ? 358 ILE D CA  1 
ATOM   2381 C C   . ILE D 2 26  ? 28.40179  43.61932  -31.60003 1.000 54.11320  ? 358 ILE D C   1 
ATOM   2382 O O   . ILE D 2 26  ? 27.32769  44.23214  -31.54431 1.000 50.29275  ? 358 ILE D O   1 
ATOM   2383 C CB  . ILE D 2 26  ? 27.71042  41.21013  -31.39034 1.000 51.17579  ? 358 ILE D CB  1 
ATOM   2384 C CG1 . ILE D 2 26  ? 27.85938  39.91652  -30.58227 1.000 47.20422  ? 358 ILE D CG1 1 
ATOM   2385 C CG2 . ILE D 2 26  ? 28.04133  40.97748  -32.85070 1.000 42.16600  ? 358 ILE D CG2 1 
ATOM   2386 C CD1 . ILE D 2 26  ? 29.24236  39.31878  -30.63453 1.000 50.95035  ? 358 ILE D CD1 1 
ATOM   2387 N N   . SER D 2 27  ? 29.43182  44.02407  -32.34259 1.000 52.48710  ? 359 SER D N   1 
ATOM   2388 C CA  . SER D 2 27  ? 29.34445  45.24500  -33.13474 1.000 52.77825  ? 359 SER D CA  1 
ATOM   2389 C C   . SER D 2 27  ? 30.29824  45.16519  -34.31967 1.000 54.40966  ? 359 SER D C   1 
ATOM   2390 O O   . SER D 2 27  ? 31.26138  44.39329  -34.31876 1.000 51.07126  ? 359 SER D O   1 
ATOM   2391 C CB  . SER D 2 27  ? 29.64567  46.48628  -32.28632 1.000 52.63592  ? 359 SER D CB  1 
ATOM   2392 O OG  . SER D 2 27  ? 30.94291  46.41443  -31.72643 1.000 63.63298  ? 359 SER D OG  1 
ATOM   2393 N N   . ASN D 2 28  ? 30.00098  45.97516  -35.33893 1.000 53.16451  ? 360 ASN D N   1 
ATOM   2394 C CA  . ASN D 2 28  ? 30.87215  46.17149  -36.49939 1.000 55.05309  ? 360 ASN D CA  1 
ATOM   2395 C C   . ASN D 2 28  ? 31.16353  44.85004  -37.20968 1.000 48.51571  ? 360 ASN D C   1 
ATOM   2396 O O   . ASN D 2 28  ? 32.30863  44.41254  -37.32800 1.000 50.57821  ? 360 ASN D O   1 
ATOM   2397 C CB  . ASN D 2 28  ? 32.16859  46.87641  -36.09101 1.000 53.88708  ? 360 ASN D CB  1 
ATOM   2398 C CG  . ASN D 2 28  ? 31.92724  48.28572  -35.60081 1.000 60.52563  ? 360 ASN D CG  1 
ATOM   2399 O OD1 . ASN D 2 28  ? 31.84287  48.53184  -34.39784 1.000 63.03888  ? 360 ASN D OD1 1 
ATOM   2400 N ND2 . ASN D 2 28  ? 31.79921  49.22183  -36.53508 1.000 75.20821  ? 360 ASN D ND2 1 
ATOM   2401 N N   . CYS D 2 29  ? 30.09716  44.22998  -37.70086 1.000 42.63934  ? 361 CYS D N   1 
ATOM   2402 C CA  . CYS D 2 29  ? 30.19493  42.91507  -38.31621 1.000 49.62354  ? 361 CYS D CA  1 
ATOM   2403 C C   . CYS D 2 29  ? 28.87275  42.60902  -39.00117 1.000 50.37184  ? 361 CYS D C   1 
ATOM   2404 O O   . CYS D 2 29  ? 27.87862  43.31894  -38.82571 1.000 46.86568  ? 361 CYS D O   1 
ATOM   2405 C CB  . CYS D 2 29  ? 30.53486  41.84049  -37.28105 1.000 56.23296  ? 361 CYS D CB  1 
ATOM   2406 S SG  . CYS D 2 29  ? 29.32189  41.68951  -35.94682 1.000 51.53413  ? 361 CYS D SG  1 
ATOM   2407 N N   . VAL D 2 30  ? 28.87635  41.53581  -39.78480 1.000 49.92431  ? 362 VAL D N   1 
ATOM   2408 C CA  . VAL D 2 30  ? 27.68046  41.03170  -40.44453 1.000 52.56096  ? 362 VAL D CA  1 
ATOM   2409 C C   . VAL D 2 30  ? 27.47739  39.58524  -40.01354 1.000 54.61206  ? 362 VAL D C   1 
ATOM   2410 O O   . VAL D 2 30  ? 28.44635  38.85482  -39.77430 1.000 58.37921  ? 362 VAL D O   1 
ATOM   2411 C CB  . VAL D 2 30  ? 27.78254  41.14893  -41.98174 1.000 56.21247  ? 362 VAL D CB  1 
ATOM   2412 C CG1 . VAL D 2 30  ? 29.01088  40.41455  -42.49539 1.000 66.34828  ? 362 VAL D CG1 1 
ATOM   2413 C CG2 . VAL D 2 30  ? 26.51559  40.63156  -42.65216 1.000 50.35463  ? 362 VAL D CG2 1 
ATOM   2414 N N   . ALA D 2 31  ? 26.21595  39.18073  -39.88714 1.000 53.72126  ? 363 ALA D N   1 
ATOM   2415 C CA  . ALA D 2 31  ? 25.87519  37.83036  -39.47369 1.000 61.26359  ? 363 ALA D CA  1 
ATOM   2416 C C   . ALA D 2 31  ? 24.67177  37.35032  -40.26707 1.000 59.34473  ? 363 ALA D C   1 
ATOM   2417 O O   . ALA D 2 31  ? 23.80552  38.13958  -40.65311 1.000 57.81792  ? 363 ALA D O   1 
ATOM   2418 C CB  . ALA D 2 31  ? 25.57771  37.75480  -37.96993 1.000 61.76329  ? 363 ALA D CB  1 
ATOM   2419 N N   . ASP D 2 32  ? 24.63014  36.04475  -40.51116 1.000 60.96194  ? 364 ASP D N   1 
ATOM   2420 C CA  . ASP D 2 32  ? 23.50171  35.40635  -41.18292 1.000 63.09434  ? 364 ASP D CA  1 
ATOM   2421 C C   . ASP D 2 32  ? 22.61577  34.79230  -40.10575 1.000 62.51129  ? 364 ASP D C   1 
ATOM   2422 O O   . ASP D 2 32  ? 22.89438  33.70057  -39.60489 1.000 68.10138  ? 364 ASP D O   1 
ATOM   2423 C CB  . ASP D 2 32  ? 23.97221  34.35817  -42.18609 1.000 59.74402  ? 364 ASP D CB  1 
ATOM   2424 C CG  . ASP D 2 32  ? 22.83106  33.78360  -43.00647 1.000 62.73254  ? 364 ASP D CG  1 
ATOM   2425 O OD1 . ASP D 2 32  ? 21.67272  34.21228  -42.81714 1.000 62.75333  ? 364 ASP D OD1 1 
ATOM   2426 O OD2 . ASP D 2 32  ? 23.09370  32.90163  -43.84761 1.000 74.79085  ? 364 ASP D OD2 1 
ATOM   2427 N N   . TYR D 2 33  ? 21.54445  35.49975  -39.75384 1.000 62.15631  ? 365 TYR D N   1 
ATOM   2428 C CA  . TYR D 2 33  ? 20.59117  35.02395  -38.76221 1.000 67.91357  ? 365 TYR D CA  1 
ATOM   2429 C C   . TYR D 2 33  ? 19.65189  33.95667  -39.30896 1.000 72.16267  ? 365 TYR D C   1 
ATOM   2430 O O   . TYR D 2 33  ? 18.88224  33.38201  -38.53376 1.000 72.59991  ? 365 TYR D O   1 
ATOM   2431 C CB  . TYR D 2 33  ? 19.77835  36.20075  -38.20892 1.000 64.29520  ? 365 TYR D CB  1 
ATOM   2432 C CG  . TYR D 2 33  ? 20.61969  37.24994  -37.51503 1.000 60.40763  ? 365 TYR D CG  1 
ATOM   2433 C CD1 . TYR D 2 33  ? 21.14038  37.02060  -36.24691 1.000 64.74400  ? 365 TYR D CD1 1 
ATOM   2434 C CD2 . TYR D 2 33  ? 20.89352  38.46881  -38.12595 1.000 55.77929  ? 365 TYR D CD2 1 
ATOM   2435 C CE1 . TYR D 2 33  ? 21.91083  37.97325  -35.60738 1.000 65.12837  ? 365 TYR D CE1 1 
ATOM   2436 C CE2 . TYR D 2 33  ? 21.66406  39.42767  -37.49517 1.000 52.98464  ? 365 TYR D CE2 1 
ATOM   2437 C CZ  . TYR D 2 33  ? 22.16686  39.17427  -36.23437 1.000 61.73076  ? 365 TYR D CZ  1 
ATOM   2438 O OH  . TYR D 2 33  ? 22.93240  40.11798  -35.59100 1.000 62.87336  ? 365 TYR D OH  1 
ATOM   2439 N N   . SER D 2 34  ? 19.67858  33.68218  -40.61711 1.000 78.82505  ? 366 SER D N   1 
ATOM   2440 C CA  . SER D 2 34  ? 18.86011  32.59708  -41.14399 1.000 78.77895  ? 366 SER D CA  1 
ATOM   2441 C C   . SER D 2 34  ? 19.38991  31.24154  -40.70631 1.000 79.48477  ? 366 SER D C   1 
ATOM   2442 O O   . SER D 2 34  ? 18.63129  30.26745  -40.68654 1.000 84.22611  ? 366 SER D O   1 
ATOM   2443 C CB  . SER D 2 34  ? 18.79024  32.66712  -42.67339 1.000 69.93053  ? 366 SER D CB  1 
ATOM   2444 O OG  . SER D 2 34  ? 20.04805  32.37299  -43.25665 1.000 77.57466  ? 366 SER D OG  1 
ATOM   2445 N N   . VAL D 2 35  ? 20.66591  31.16700  -40.33574 1.000 75.99608  ? 367 VAL D N   1 
ATOM   2446 C CA  . VAL D 2 35  ? 21.26534  29.93107  -39.85861 1.000 81.19160  ? 367 VAL D CA  1 
ATOM   2447 C C   . VAL D 2 35  ? 21.20658  29.91720  -38.33495 1.000 83.19099  ? 367 VAL D C   1 
ATOM   2448 O O   . VAL D 2 35  ? 21.90381  29.13090  -37.68549 1.000 86.32379  ? 367 VAL D O   1 
ATOM   2449 C CB  . VAL D 2 35  ? 22.70670  29.80053  -40.38543 1.000 81.93500  ? 367 VAL D CB  1 
ATOM   2450 C CG1 . VAL D 2 35  ? 23.21832  28.36471  -40.24191 1.000 97.77395  ? 367 VAL D CG1 1 
ATOM   2451 C CG2 . VAL D 2 35  ? 22.77739  30.26838  -41.83742 1.000 80.95350  ? 367 VAL D CG2 1 
ATOM   2452 N N   . LEU D 2 36  ? 20.37222  30.79074  -37.75426 1.000 80.58986  ? 368 LEU D N   1 
ATOM   2453 C CA  . LEU D 2 36  ? 20.27720  30.87020  -36.29843 1.000 84.13407  ? 368 LEU D CA  1 
ATOM   2454 C C   . LEU D 2 36  ? 19.79477  29.55646  -35.71034 1.000 87.42067  ? 368 LEU D C   1 
ATOM   2455 O O   . LEU D 2 36  ? 20.23671  29.15678  -34.62748 1.000 90.69680  ? 368 LEU D O   1 
ATOM   2456 C CB  . LEU D 2 36  ? 19.34890  32.01254  -35.87448 1.000 80.10671  ? 368 LEU D CB  1 
ATOM   2457 C CG  . LEU D 2 36  ? 19.09816  32.22489  -34.37392 1.000 71.68245  ? 368 LEU D CG  1 
ATOM   2458 C CD1 . LEU D 2 36  ? 19.06200  33.70498  -34.00548 1.000 70.17748  ? 368 LEU D CD1 1 
ATOM   2459 C CD2 . LEU D 2 36  ? 17.80441  31.56112  -33.94444 1.000 63.71626  ? 368 LEU D CD2 1 
ATOM   2460 N N   . TYR D 2 37  ? 18.87284  28.87936  -36.39845 1.000 82.32289  ? 369 TYR D N   1 
ATOM   2461 C CA  . TYR D 2 37  ? 18.42541  27.56623  -35.95560 1.000 86.07723  ? 369 TYR D CA  1 
ATOM   2462 C C   . TYR D 2 37  ? 19.57121  26.56008  -35.90830 1.000 96.04252  ? 369 TYR D C   1 
ATOM   2463 O O   . TYR D 2 37  ? 19.41922  25.50262  -35.28802 1.000 91.83490  ? 369 TYR D O   1 
ATOM   2464 C CB  . TYR D 2 37  ? 17.31572  27.04417  -36.88744 1.000 79.76327  ? 369 TYR D CB  1 
ATOM   2465 C CG  . TYR D 2 37  ? 17.82767  26.52447  -38.20229 1.000 84.67209  ? 369 TYR D CG  1 
ATOM   2466 C CD1 . TYR D 2 37  ? 18.24394  27.39841  -39.19411 1.000 87.91948  ? 369 TYR D CD1 1 
ATOM   2467 C CD2 . TYR D 2 37  ? 17.90724  25.15935  -38.44832 1.000 91.74672  ? 369 TYR D CD2 1 
ATOM   2468 C CE1 . TYR D 2 37  ? 18.72760  26.92839  -40.40277 1.000 92.13354  ? 369 TYR D CE1 1 
ATOM   2469 C CE2 . TYR D 2 37  ? 18.38719  24.68099  -39.65388 1.000 98.54781  ? 369 TYR D CE2 1 
ATOM   2470 C CZ  . TYR D 2 37  ? 18.79680  25.56914  -40.62856 1.000 99.42452  ? 369 TYR D CZ  1 
ATOM   2471 O OH  . TYR D 2 37  ? 19.27623  25.09021  -41.82911 1.000 93.32865  ? 369 TYR D OH  1 
ATOM   2472 N N   . ASN D 2 38  ? 20.71726  26.86785  -36.52463 1.000 93.33439  ? 370 ASN D N   1 
ATOM   2473 C CA  . ASN D 2 38  ? 21.89103  26.00796  -36.47123 1.000 90.66612  ? 370 ASN D CA  1 
ATOM   2474 C C   . ASN D 2 38  ? 23.05518  26.61220  -35.69189 1.000 88.67366  ? 370 ASN D C   1 
ATOM   2475 O O   . ASN D 2 38  ? 24.12076  25.98672  -35.62533 1.000 87.64309  ? 370 ASN D O   1 
ATOM   2476 C CB  . ASN D 2 38  ? 22.35280  25.66473  -37.89133 1.000 85.94128  ? 370 ASN D CB  1 
ATOM   2477 C CG  . ASN D 2 38  ? 21.59843  24.49522  -38.49830 1.000 95.03905  ? 370 ASN D CG  1 
ATOM   2478 O OD1 . ASN D 2 38  ? 21.04262  23.65354  -37.79643 1.000 96.28969  ? 370 ASN D OD1 1 
ATOM   2479 N ND2 . ASN D 2 38  ? 21.60874  24.42508  -39.82623 1.000 95.12761  ? 370 ASN D ND2 1 
ATOM   2480 N N   . PHE D 2 39  ? 22.89867  27.81570  -35.12882 1.000 83.67791  ? 371 PHE D N   1 
ATOM   2481 C CA  . PHE D 2 39  ? 23.96073  28.39853  -34.30905 1.000 81.92212  ? 371 PHE D CA  1 
ATOM   2482 C C   . PHE D 2 39  ? 24.35458  27.44891  -33.18539 1.000 80.76248  ? 371 PHE D C   1 
ATOM   2483 O O   . PHE D 2 39  ? 25.52786  27.08858  -33.02871 1.000 77.56359  ? 371 PHE D O   1 
ATOM   2484 C CB  . PHE D 2 39  ? 23.51582  29.74749  -33.73366 1.000 78.21936  ? 371 PHE D CB  1 
ATOM   2485 C CG  . PHE D 2 39  ? 23.48696  30.87036  -34.73743 1.000 83.50555  ? 371 PHE D CG  1 
ATOM   2486 C CD1 . PHE D 2 39  ? 23.96482  30.68776  -36.02709 1.000 83.77188  ? 371 PHE D CD1 1 
ATOM   2487 C CD2 . PHE D 2 39  ? 22.99074  32.11777  -34.38264 1.000 78.24508  ? 371 PHE D CD2 1 
ATOM   2488 C CE1 . PHE D 2 39  ? 23.93858  31.71941  -36.94808 1.000 78.74916  ? 371 PHE D CE1 1 
ATOM   2489 C CE2 . PHE D 2 39  ? 22.96404  33.15527  -35.29861 1.000 76.76524  ? 371 PHE D CE2 1 
ATOM   2490 C CZ  . PHE D 2 39  ? 23.43999  32.95522  -36.58292 1.000 75.50378  ? 371 PHE D CZ  1 
ATOM   2491 N N   . ALA D 2 40  ? 23.37660  27.04205  -32.38734 1.000 80.38015  ? 372 ALA D N   1 
ATOM   2492 C CA  . ALA D 2 40  ? 23.56374  25.98032  -31.42317 1.000 78.87227  ? 372 ALA D CA  1 
ATOM   2493 C C   . ALA D 2 40  ? 23.03255  24.68587  -32.01064 1.000 84.34909  ? 372 ALA D C   1 
ATOM   2494 O O   . ALA D 2 40  ? 21.83597  24.61211  -32.33706 1.000 85.88922  ? 372 ALA D O   1 
ATOM   2495 C CB  . ALA D 2 40  ? 22.83835  26.30247  -30.13219 1.000 66.81105  ? 372 ALA D CB  1 
ATOM   2496 N N   . PRO D 2 41  ? 23.86275  23.66492  -32.19657 1.000 83.98975  ? 373 PRO D N   1 
ATOM   2497 C CA  . PRO D 2 41  ? 23.35436  22.39272  -32.72304 1.000 83.14058  ? 373 PRO D CA  1 
ATOM   2498 C C   . PRO D 2 41  ? 22.50733  21.65531  -31.69353 1.000 82.26707  ? 373 PRO D C   1 
ATOM   2499 O O   . PRO D 2 41  ? 22.74470  21.73799  -30.48534 1.000 74.55328  ? 373 PRO D O   1 
ATOM   2500 C CB  . PRO D 2 41  ? 24.63148  21.60928  -33.05887 1.000 77.63718  ? 373 PRO D CB  1 
ATOM   2501 C CG  . PRO D 2 41  ? 25.73215  22.65116  -33.09932 1.000 79.14146  ? 373 PRO D CG  1 
ATOM   2502 C CD  . PRO D 2 41  ? 25.32975  23.67786  -32.09616 1.000 77.19825  ? 373 PRO D CD  1 
ATOM   2503 N N   . PHE D 2 42  ? 21.50793  20.92225  -32.19695 1.000 75.73639  ? 374 PHE D N   1 
ATOM   2504 C CA  . PHE D 2 42  ? 20.58187  20.14828  -31.36530 1.000 78.23162  ? 374 PHE D CA  1 
ATOM   2505 C C   . PHE D 2 42  ? 19.90143  21.03020  -30.31924 1.000 76.90931  ? 374 PHE D C   1 
ATOM   2506 O O   . PHE D 2 42  ? 19.76725  20.64968  -29.15316 1.000 73.47047  ? 374 PHE D O   1 
ATOM   2507 C CB  . PHE D 2 42  ? 21.28568  18.96455  -30.69209 1.000 77.11787  ? 374 PHE D CB  1 
ATOM   2508 C CG  . PHE D 2 42  ? 22.23435  18.22277  -31.59019 1.000 78.86824  ? 374 PHE D CG  1 
ATOM   2509 C CD1 . PHE D 2 42  ? 21.76084  17.41736  -32.61554 1.000 79.90061  ? 374 PHE D CD1 1 
ATOM   2510 C CD2 . PHE D 2 42  ? 23.60425  18.32833  -31.40292 1.000 80.01122  ? 374 PHE D CD2 1 
ATOM   2511 C CE1 . PHE D 2 42  ? 22.63767  16.73592  -33.44461 1.000 78.59292  ? 374 PHE D CE1 1 
ATOM   2512 C CE2 . PHE D 2 42  ? 24.48599  17.65072  -32.22647 1.000 84.79478  ? 374 PHE D CE2 1 
ATOM   2513 C CZ  . PHE D 2 42  ? 24.00363  16.85362  -33.24759 1.000 85.23496  ? 374 PHE D CZ  1 
ATOM   2514 N N   . SER D 2 43  ? 19.45723  22.21106  -30.73589 1.000 65.05095  ? 375 SER D N   1 
ATOM   2515 C CA  . SER D 2 43  ? 18.94457  23.21410  -29.81349 1.000 63.90686  ? 375 SER D CA  1 
ATOM   2516 C C   . SER D 2 43  ? 17.47110  23.49448  -30.07842 1.000 63.69834  ? 375 SER D C   1 
ATOM   2517 O O   . SER D 2 43  ? 16.85670  22.95035  -30.99853 1.000 71.94261  ? 375 SER D O   1 
ATOM   2518 C CB  . SER D 2 43  ? 19.75452  24.50839  -29.91649 1.000 64.04526  ? 375 SER D CB  1 
ATOM   2519 O OG  . SER D 2 43  ? 19.64230  25.07624  -31.20972 1.000 69.27147  ? 375 SER D OG  1 
ATOM   2520 N N   . ALA D 2 44  ? 16.91351  24.35126  -29.23035 1.000 56.14586  ? 376 ALA D N   1 
ATOM   2521 C CA  . ALA D 2 44  ? 15.60165  24.94389  -29.41985 1.000 53.59743  ? 376 ALA D CA  1 
ATOM   2522 C C   . ALA D 2 44  ? 15.75455  26.45102  -29.30075 1.000 53.31466  ? 376 ALA D C   1 
ATOM   2523 O O   . ALA D 2 44  ? 16.54474  26.93718  -28.48599 1.000 45.17340  ? 376 ALA D O   1 
ATOM   2524 C CB  . ALA D 2 44  ? 14.59087  24.42559  -28.38973 1.000 48.01024  ? 376 ALA D CB  1 
ATOM   2525 N N   . PHE D 2 45  ? 15.01840  27.18953  -30.12596 1.000 53.30207  ? 377 PHE D N   1 
ATOM   2526 C CA  . PHE D 2 45  ? 15.08336  28.63998  -30.08737 1.000 50.78317  ? 377 PHE D CA  1 
ATOM   2527 C C   . PHE D 2 45  ? 13.67524  29.20624  -30.18025 1.000 49.81183  ? 377 PHE D C   1 
ATOM   2528 O O   . PHE D 2 45  ? 12.74659  28.54709  -30.65317 1.000 54.54428  ? 377 PHE D O   1 
ATOM   2529 C CB  . PHE D 2 45  ? 15.97097  29.20136  -31.21325 1.000 48.73933  ? 377 PHE D CB  1 
ATOM   2530 C CG  . PHE D 2 45  ? 15.28141  29.30115  -32.54693 1.000 52.64497  ? 377 PHE D CG  1 
ATOM   2531 C CD1 . PHE D 2 45  ? 15.26585  28.22761  -33.41948 1.000 59.42437  ? 377 PHE D CD1 1 
ATOM   2532 C CD2 . PHE D 2 45  ? 14.66357  30.47958  -32.93505 1.000 55.05974  ? 377 PHE D CD2 1 
ATOM   2533 C CE1 . PHE D 2 45  ? 14.63644  28.32526  -34.65001 1.000 60.87682  ? 377 PHE D CE1 1 
ATOM   2534 C CE2 . PHE D 2 45  ? 14.03157  30.58167  -34.15867 1.000 54.33919  ? 377 PHE D CE2 1 
ATOM   2535 C CZ  . PHE D 2 45  ? 14.01909  29.50543  -35.01808 1.000 58.20251  ? 377 PHE D CZ  1 
ATOM   2536 N N   . LYS D 2 46  ? 13.52505  30.44009  -29.70770 1.000 47.20175  ? 378 LYS D N   1 
ATOM   2537 C CA  . LYS D 2 46  ? 12.28893  31.18676  -29.90421 1.000 49.13579  ? 378 LYS D CA  1 
ATOM   2538 C C   . LYS D 2 46  ? 12.63906  32.65936  -30.00715 1.000 52.37484  ? 378 LYS D C   1 
ATOM   2539 O O   . LYS D 2 46  ? 13.33135  33.19605  -29.13900 1.000 49.22600  ? 378 LYS D O   1 
ATOM   2540 C CB  . LYS D 2 46  ? 11.29433  30.94915  -28.76971 1.000 50.93793  ? 378 LYS D CB  1 
ATOM   2541 C CG  . LYS D 2 46  ? 10.00911  31.75741  -28.91186 1.000 51.68637  ? 378 LYS D CG  1 
ATOM   2542 C CD  . LYS D 2 46  ? 8.93673   31.27258  -27.94843 1.000 58.21609  ? 378 LYS D CD  1 
ATOM   2543 C CE  . LYS D 2 46  ? 7.63462   32.03390  -28.14404 1.000 65.14546  ? 378 LYS D CE  1 
ATOM   2544 N NZ  . LYS D 2 46  ? 7.21645   32.02705  -29.57719 1.000 64.08191  ? 378 LYS D NZ  1 
ATOM   2545 N N   . CYS D 2 47  ? 12.17425  33.30092  -31.06922 1.000 55.09689  ? 379 CYS D N   1 
ATOM   2546 C CA  . CYS D 2 47  ? 12.34023  34.73341  -31.24952 1.000 50.33157  ? 379 CYS D CA  1 
ATOM   2547 C C   . CYS D 2 47  ? 11.02182  35.41876  -30.92481 1.000 45.82805  ? 379 CYS D C   1 
ATOM   2548 O O   . CYS D 2 47  ? 9.96965   35.02545  -31.43807 1.000 53.16202  ? 379 CYS D O   1 
ATOM   2549 C CB  . CYS D 2 47  ? 12.79043  35.05128  -32.67355 1.000 48.17551  ? 379 CYS D CB  1 
ATOM   2550 S SG  . CYS D 2 47  ? 14.43955  34.40596  -33.05313 1.000 60.57969  ? 379 CYS D SG  1 
ATOM   2551 N N   . TYR D 2 48  ? 11.07804  36.41856  -30.05192 1.000 46.64914  ? 380 TYR D N   1 
ATOM   2552 C CA  . TYR D 2 48  ? 9.88244   37.09506  -29.57122 1.000 47.47035  ? 380 TYR D CA  1 
ATOM   2553 C C   . TYR D 2 48  ? 9.55192   38.35208  -30.35961 1.000 53.00107  ? 380 TYR D C   1 
ATOM   2554 O O   . TYR D 2 48  ? 8.51023   38.96605  -30.10893 1.000 54.84707  ? 380 TYR D O   1 
ATOM   2555 C CB  . TYR D 2 48  ? 10.04003  37.42826  -28.08648 1.000 51.23787  ? 380 TYR D CB  1 
ATOM   2556 C CG  . TYR D 2 48  ? 10.09825  36.18521  -27.23349 1.000 48.10652  ? 380 TYR D CG  1 
ATOM   2557 C CD1 . TYR D 2 48  ? 11.30217  35.53306  -27.00822 1.000 45.33740  ? 380 TYR D CD1 1 
ATOM   2558 C CD2 . TYR D 2 48  ? 8.94414   35.64480  -26.68537 1.000 48.42248  ? 380 TYR D CD2 1 
ATOM   2559 C CE1 . TYR D 2 48  ? 11.35863  34.38930  -26.24558 1.000 50.74350  ? 380 TYR D CE1 1 
ATOM   2560 C CE2 . TYR D 2 48  ? 8.98872   34.50138  -25.91830 1.000 53.07190  ? 380 TYR D CE2 1 
ATOM   2561 C CZ  . TYR D 2 48  ? 10.19854  33.87842  -25.70074 1.000 51.47557  ? 380 TYR D CZ  1 
ATOM   2562 O OH  . TYR D 2 48  ? 10.24891  32.73732  -24.93822 1.000 53.16750  ? 380 TYR D OH  1 
ATOM   2563 N N   . GLY D 2 49  ? 10.40887  38.74594  -31.29628 1.000 53.78961  ? 381 GLY D N   1 
ATOM   2564 C CA  . GLY D 2 49  ? 10.11348  39.84122  -32.19447 1.000 55.65176  ? 381 GLY D CA  1 
ATOM   2565 C C   . GLY D 2 49  ? 9.96703   39.33604  -33.61211 1.000 59.10745  ? 381 GLY D C   1 
ATOM   2566 O O   . GLY D 2 49  ? 9.08613   38.51896  -33.89529 1.000 62.14069  ? 381 GLY D O   1 
ATOM   2567 N N   . VAL D 2 50  ? 10.82982  39.79715  -34.51068 1.000 57.39942  ? 382 VAL D N   1 
ATOM   2568 C CA  . VAL D 2 50  ? 10.76849  39.33371  -35.88872 1.000 64.58258  ? 382 VAL D CA  1 
ATOM   2569 C C   . VAL D 2 50  ? 11.53456  38.02252  -36.02301 1.000 60.12961  ? 382 VAL D C   1 
ATOM   2570 O O   . VAL D 2 50  ? 12.41213  37.69567  -35.22078 1.000 61.21413  ? 382 VAL D O   1 
ATOM   2571 C CB  . VAL D 2 50  ? 11.30007  40.40021  -36.86282 1.000 62.63985  ? 382 VAL D CB  1 
ATOM   2572 C CG1 . VAL D 2 50  ? 10.41431  41.63463  -36.82250 1.000 63.89817  ? 382 VAL D CG1 1 
ATOM   2573 C CG2 . VAL D 2 50  ? 12.73194  40.76241  -36.53077 1.000 64.02251  ? 382 VAL D CG2 1 
ATOM   2574 N N   . SER D 2 51  ? 11.17960  37.25669  -37.05094 1.000 63.79970  ? 383 SER D N   1 
ATOM   2575 C CA  . SER D 2 51  ? 11.77547  35.95092  -37.26365 1.000 61.20025  ? 383 SER D CA  1 
ATOM   2576 C C   . SER D 2 51  ? 13.25616  36.08995  -37.61024 1.000 60.76542  ? 383 SER D C   1 
ATOM   2577 O O   . SER D 2 51  ? 13.72572  37.18053  -37.94426 1.000 60.39032  ? 383 SER D O   1 
ATOM   2578 C CB  . SER D 2 51  ? 11.04186  35.21146  -38.38145 1.000 63.37301  ? 383 SER D CB  1 
ATOM   2579 O OG  . SER D 2 51  ? 11.42276  35.70359  -39.65457 1.000 66.53743  ? 383 SER D OG  1 
ATOM   2580 N N   . PRO D 2 52  ? 14.01897  34.99594  -37.51859 1.000 58.67143  ? 384 PRO D N   1 
ATOM   2581 C CA  . PRO D 2 52  ? 15.41729  35.04803  -37.97412 1.000 59.31662  ? 384 PRO D CA  1 
ATOM   2582 C C   . PRO D 2 52  ? 15.56424  35.45858  -39.42927 1.000 64.19621  ? 384 PRO D C   1 
ATOM   2583 O O   . PRO D 2 52  ? 16.56025  36.10193  -39.78609 1.000 58.97926  ? 384 PRO D O   1 
ATOM   2584 C CB  . PRO D 2 52  ? 15.90858  33.61483  -37.73587 1.000 56.57094  ? 384 PRO D CB  1 
ATOM   2585 C CG  . PRO D 2 52  ? 15.07104  33.11936  -36.61771 1.000 54.49792  ? 384 PRO D CG  1 
ATOM   2586 C CD  . PRO D 2 52  ? 13.71594  33.73258  -36.82027 1.000 57.63239  ? 384 PRO D CD  1 
ATOM   2587 N N   . THR D 2 53  ? 14.60382  35.10422  -40.28447 1.000 58.85201  ? 385 THR D N   1 
ATOM   2588 C CA  . THR D 2 53  ? 14.65848  35.54591  -41.67367 1.000 66.29633  ? 385 THR D CA  1 
ATOM   2589 C C   . THR D 2 53  ? 14.50681  37.05957  -41.76763 1.000 66.47519  ? 385 THR D C   1 
ATOM   2590 O O   . THR D 2 53  ? 15.31186  37.73477  -42.42008 1.000 65.04515  ? 385 THR D O   1 
ATOM   2591 C CB  . THR D 2 53  ? 13.57959  34.83849  -42.49554 1.000 62.61036  ? 385 THR D CB  1 
ATOM   2592 O OG1 . THR D 2 53  ? 13.88470  33.43992  -42.58290 1.000 59.80298  ? 385 THR D OG1 1 
ATOM   2593 C CG2 . THR D 2 53  ? 13.50707  35.42568  -43.89803 1.000 66.08495  ? 385 THR D CG2 1 
ATOM   2594 N N   . LYS D 2 54  ? 13.48703  37.61226  -41.10355 1.000 58.80057  ? 386 LYS D N   1 
ATOM   2595 C CA  . LYS D 2 54  ? 13.29730  39.05895  -41.10038 1.000 60.47819  ? 386 LYS D CA  1 
ATOM   2596 C C   . LYS D 2 54  ? 14.43762  39.77860  -40.38784 1.000 62.68367  ? 386 LYS D C   1 
ATOM   2597 O O   . LYS D 2 54  ? 14.72312  40.93875  -40.70269 1.000 65.97827  ? 386 LYS D O   1 
ATOM   2598 C CB  . LYS D 2 54  ? 11.95263  39.41018  -40.45865 1.000 66.36768  ? 386 LYS D CB  1 
ATOM   2599 C CG  . LYS D 2 54  ? 10.74021  38.94315  -41.26487 1.000 76.01214  ? 386 LYS D CG  1 
ATOM   2600 C CD  . LYS D 2 54  ? 9.66896   38.30742  -40.37660 1.000 81.08610  ? 386 LYS D CD  1 
ATOM   2601 C CE  . LYS D 2 54  ? 9.04261   39.31618  -39.42314 1.000 78.69562  ? 386 LYS D CE  1 
ATOM   2602 N NZ  . LYS D 2 54  ? 8.07436   38.67490  -38.48483 1.000 73.43910  ? 386 LYS D NZ  1 
ATOM   2603 N N   . LEU D 2 55  ? 15.10026  39.11654  -39.43275 1.000 62.64539  ? 387 LEU D N   1 
ATOM   2604 C CA  . LEU D 2 55  ? 16.26645  39.72107  -38.79353 1.000 60.58057  ? 387 LEU D CA  1 
ATOM   2605 C C   . LEU D 2 55  ? 17.41857  39.88227  -39.77346 1.000 59.98170  ? 387 LEU D C   1 
ATOM   2606 O O   . LEU D 2 55  ? 18.26842  40.76202  -39.59249 1.000 58.15684  ? 387 LEU D O   1 
ATOM   2607 C CB  . LEU D 2 55  ? 16.71991  38.88277  -37.59495 1.000 58.14871  ? 387 LEU D CB  1 
ATOM   2608 C CG  . LEU D 2 55  ? 15.98422  39.04931  -36.26220 1.000 56.41058  ? 387 LEU D CG  1 
ATOM   2609 C CD1 . LEU D 2 55  ? 16.46287  38.01291  -35.25499 1.000 51.24570  ? 387 LEU D CD1 1 
ATOM   2610 C CD2 . LEU D 2 55  ? 16.17656  40.45511  -35.71231 1.000 51.75378  ? 387 LEU D CD2 1 
ATOM   2611 N N   . ASN D 2 56  ? 17.46276  39.04982  -40.81338 1.000 60.88580  ? 388 ASN D N   1 
ATOM   2612 C CA  . ASN D 2 56  ? 18.56052  39.09642  -41.76736 1.000 61.41884  ? 388 ASN D CA  1 
ATOM   2613 C C   . ASN D 2 56  ? 18.52666  40.33456  -42.65259 1.000 60.26581  ? 388 ASN D C   1 
ATOM   2614 O O   . ASN D 2 56  ? 19.52615  40.62167  -43.32116 1.000 52.78897  ? 388 ASN D O   1 
ATOM   2615 C CB  . ASN D 2 56  ? 18.54642  37.83927  -42.63225 1.000 54.70654  ? 388 ASN D CB  1 
ATOM   2616 C CG  . ASN D 2 56  ? 19.90412  37.19282  -42.72436 1.000 60.69428  ? 388 ASN D CG  1 
ATOM   2617 O OD1 . ASN D 2 56  ? 20.78767  37.47176  -41.91592 1.000 59.25875  ? 388 ASN D OD1 1 
ATOM   2618 N ND2 . ASN D 2 56  ? 20.08255  36.32248  -43.71069 1.000 64.80794  ? 388 ASN D ND2 1 
ATOM   2619 N N   . ASP D 2 57  ? 17.41682  41.06925  -42.66891 1.000 55.22243  ? 389 ASP D N   1 
ATOM   2620 C CA  . ASP D 2 57  ? 17.28872  42.28338  -43.46105 1.000 60.22379  ? 389 ASP D CA  1 
ATOM   2621 C C   . ASP D 2 57  ? 17.52403  43.55240  -42.65458 1.000 62.96861  ? 389 ASP D C   1 
ATOM   2622 O O   . ASP D 2 57  ? 17.44572  44.64680  -43.22045 1.000 64.83939  ? 389 ASP D O   1 
ATOM   2623 C CB  . ASP D 2 57  ? 15.89858  42.35070  -44.10522 1.000 61.00145  ? 389 ASP D CB  1 
ATOM   2624 C CG  . ASP D 2 57  ? 15.59346  41.14457  -44.96648 1.000 61.78421  ? 389 ASP D CG  1 
ATOM   2625 O OD1 . ASP D 2 57  ? 16.54757  40.51234  -45.46759 1.000 61.10683  ? 389 ASP D OD1 1 
ATOM   2626 O OD2 . ASP D 2 57  ? 14.39633  40.83419  -45.14287 1.000 65.30867  ? 389 ASP D OD2 1 
ATOM   2627 N N   . LEU D 2 58  ? 17.80616  43.44131  -41.35902 1.000 56.97930  ? 390 LEU D N   1 
ATOM   2628 C CA  . LEU D 2 58  ? 17.85107  44.59605  -40.47673 1.000 50.92049  ? 390 LEU D CA  1 
ATOM   2629 C C   . LEU D 2 58  ? 19.27253  44.88341  -40.00909 1.000 50.83569  ? 390 LEU D C   1 
ATOM   2630 O O   . LEU D 2 58  ? 20.16543  44.03551  -40.08067 1.000 51.73193  ? 390 LEU D O   1 
ATOM   2631 C CB  . LEU D 2 58  ? 16.94021  44.38799  -39.26376 1.000 46.59088  ? 390 LEU D CB  1 
ATOM   2632 C CG  . LEU D 2 58  ? 15.46119  44.14323  -39.56423 1.000 58.48231  ? 390 LEU D CG  1 
ATOM   2633 C CD1 . LEU D 2 58  ? 14.69263  43.85334  -38.28303 1.000 48.50526  ? 390 LEU D CD1 1 
ATOM   2634 C CD2 . LEU D 2 58  ? 14.85885  45.33321  -40.29794 1.000 58.67389  ? 390 LEU D CD2 1 
ATOM   2635 N N   . CYS D 2 59  ? 19.46798  46.10782  -39.52761 1.000 46.90184  ? 391 CYS D N   1 
ATOM   2636 C CA  . CYS D 2 59  ? 20.70771  46.52837  -38.89492 1.000 46.81069  ? 391 CYS D CA  1 
ATOM   2637 C C   . CYS D 2 59  ? 20.40140  47.07151  -37.50564 1.000 45.02121  ? 391 CYS D C   1 
ATOM   2638 O O   . CYS D 2 59  ? 19.29972  47.56601  -37.24502 1.000 48.29183  ? 391 CYS D O   1 
ATOM   2639 C CB  . CYS D 2 59  ? 21.43298  47.59996  -39.72383 1.000 50.47689  ? 391 CYS D CB  1 
ATOM   2640 S SG  . CYS D 2 59  ? 21.99807  47.07604  -41.37484 1.000 52.03649  ? 391 CYS D SG  1 
ATOM   2641 N N   . PHE D 2 60  ? 21.38819  46.98491  -36.61544 1.000 40.89680  ? 392 PHE D N   1 
ATOM   2642 C CA  . PHE D 2 60  ? 21.21732  47.41301  -35.23467 1.000 46.40523  ? 392 PHE D CA  1 
ATOM   2643 C C   . PHE D 2 60  ? 22.49677  48.07683  -34.74089 1.000 46.12625  ? 392 PHE D C   1 
ATOM   2644 O O   . PHE D 2 60  ? 23.59057  47.82344  -35.25114 1.000 48.34625  ? 392 PHE D O   1 
ATOM   2645 C CB  . PHE D 2 60  ? 20.83869  46.23275  -34.32210 1.000 44.19588  ? 392 PHE D CB  1 
ATOM   2646 C CG  . PHE D 2 60  ? 19.49804  45.61971  -34.64322 1.000 39.55170  ? 392 PHE D CG  1 
ATOM   2647 C CD1 . PHE D 2 60  ? 18.32838  46.18817  -34.16886 1.000 42.90031  ? 392 PHE D CD1 1 
ATOM   2648 C CD2 . PHE D 2 60  ? 19.40913  44.47610  -35.41510 1.000 42.98876  ? 392 PHE D CD2 1 
ATOM   2649 C CE1 . PHE D 2 60  ? 17.09631  45.62923  -34.46154 1.000 39.51021  ? 392 PHE D CE1 1 
ATOM   2650 C CE2 . PHE D 2 60  ? 18.17819  43.91495  -35.70761 1.000 43.08976  ? 392 PHE D CE2 1 
ATOM   2651 C CZ  . PHE D 2 60  ? 17.02315  44.49312  -35.22927 1.000 36.34708  ? 392 PHE D CZ  1 
ATOM   2652 N N   . THR D 2 61  ? 22.34150  48.94107  -33.73385 1.000 39.83161  ? 393 THR D N   1 
ATOM   2653 C CA  . THR D 2 61  ? 23.49358  49.60770  -33.13154 1.000 44.20372  ? 393 THR D CA  1 
ATOM   2654 C C   . THR D 2 61  ? 24.43882  48.59798  -32.49550 1.000 52.32387  ? 393 THR D C   1 
ATOM   2655 O O   . THR D 2 61  ? 25.64910  48.61251  -32.74711 1.000 52.15362  ? 393 THR D O   1 
ATOM   2656 C CB  . THR D 2 61  ? 23.02911  50.61743  -32.08180 1.000 41.52292  ? 393 THR D CB  1 
ATOM   2657 O OG1 . THR D 2 61  ? 21.96382  51.41386  -32.61408 1.000 47.74860  ? 393 THR D OG1 1 
ATOM   2658 C CG2 . THR D 2 61  ? 24.18237  51.52313  -31.66537 1.000 40.00769  ? 393 THR D CG2 1 
ATOM   2659 N N   . ASN D 2 62  ? 23.90135  47.72605  -31.64736 1.000 50.45052  ? 394 ASN D N   1 
ATOM   2660 C CA  . ASN D 2 62  ? 24.67258  46.65981  -31.03166 1.000 51.84960  ? 394 ASN D CA  1 
ATOM   2661 C C   . ASN D 2 62  ? 23.79103  45.42823  -30.90733 1.000 52.40285  ? 394 ASN D C   1 
ATOM   2662 O O   . ASN D 2 62  ? 22.55958  45.51302  -30.90338 1.000 46.86710  ? 394 ASN D O   1 
ATOM   2663 C CB  . ASN D 2 62  ? 25.20089  47.05017  -29.64641 1.000 44.39868  ? 394 ASN D CB  1 
ATOM   2664 C CG  . ASN D 2 62  ? 26.24482  48.14168  -29.70242 1.000 54.71722  ? 394 ASN D CG  1 
ATOM   2665 O OD1 . ASN D 2 62  ? 27.41315  47.88098  -29.98886 1.000 56.63399  ? 394 ASN D OD1 1 
ATOM   2666 N ND2 . ASN D 2 62  ? 25.83549  49.37092  -29.40661 1.000 58.14046  ? 394 ASN D ND2 1 
ATOM   2667 N N   . VAL D 2 63  ? 24.44078  44.27662  -30.80232 1.000 50.40823  ? 395 VAL D N   1 
ATOM   2668 C CA  . VAL D 2 63  ? 23.78957  43.03770  -30.40465 1.000 43.67826  ? 395 VAL D CA  1 
ATOM   2669 C C   . VAL D 2 63  ? 24.48091  42.54392  -29.14539 1.000 44.52790  ? 395 VAL D C   1 
ATOM   2670 O O   . VAL D 2 63  ? 25.71548  42.50093  -29.08335 1.000 45.16955  ? 395 VAL D O   1 
ATOM   2671 C CB  . VAL D 2 63  ? 23.83552  41.97499  -31.51562 1.000 51.34298  ? 395 VAL D CB  1 
ATOM   2672 C CG1 . VAL D 2 63  ? 23.35479  40.63863  -30.97922 1.000 49.25891  ? 395 VAL D CG1 1 
ATOM   2673 C CG2 . VAL D 2 63  ? 22.98057  42.41296  -32.69710 1.000 40.96970  ? 395 VAL D CG2 1 
ATOM   2674 N N   . TYR D 2 64  ? 23.68988  42.20745  -28.13580 1.000 40.34346  ? 396 TYR D N   1 
ATOM   2675 C CA  . TYR D 2 64  ? 24.20233  41.66900  -26.88755 1.000 41.74707  ? 396 TYR D CA  1 
ATOM   2676 C C   . TYR D 2 64  ? 23.86054  40.18893  -26.81395 1.000 42.16311  ? 396 TYR D C   1 
ATOM   2677 O O   . TYR D 2 64  ? 22.70136  39.80260  -27.00473 1.000 45.88462  ? 396 TYR D O   1 
ATOM   2678 C CB  . TYR D 2 64  ? 23.62792  42.42781  -25.68922 1.000 44.27174  ? 396 TYR D CB  1 
ATOM   2679 C CG  . TYR D 2 64  ? 23.89585  43.91451  -25.75145 1.000 42.60511  ? 396 TYR D CG  1 
ATOM   2680 C CD1 . TYR D 2 64  ? 25.10594  44.44113  -25.32015 1.000 43.62146  ? 396 TYR D CD1 1 
ATOM   2681 C CD2 . TYR D 2 64  ? 22.94400  44.79023  -26.26061 1.000 47.51924  ? 396 TYR D CD2 1 
ATOM   2682 C CE1 . TYR D 2 64  ? 25.35851  45.80221  -25.38763 1.000 50.28677  ? 396 TYR D CE1 1 
ATOM   2683 C CE2 . TYR D 2 64  ? 23.18494  46.15061  -26.32888 1.000 45.70099  ? 396 TYR D CE2 1 
ATOM   2684 C CZ  . TYR D 2 64  ? 24.39286  46.65106  -25.89128 1.000 49.36277  ? 396 TYR D CZ  1 
ATOM   2685 O OH  . TYR D 2 64  ? 24.63623  48.00335  -25.95749 1.000 52.83883  ? 396 TYR D OH  1 
ATOM   2686 N N   . ALA D 2 65  ? 24.87540  39.36733  -26.56558 1.000 39.97695  ? 397 ALA D N   1 
ATOM   2687 C CA  . ALA D 2 65  ? 24.72006  37.92608  -26.41313 1.000 39.91928  ? 397 ALA D CA  1 
ATOM   2688 C C   . ALA D 2 65  ? 24.98934  37.58047  -24.95536 1.000 39.04181  ? 397 ALA D C   1 
ATOM   2689 O O   . ALA D 2 65  ? 26.12995  37.67215  -24.49182 1.000 40.33906  ? 397 ALA D O   1 
ATOM   2690 C CB  . ALA D 2 65  ? 25.66552  37.16677  -27.34228 1.000 37.63704  ? 397 ALA D CB  1 
ATOM   2691 N N   . ASP D 2 66  ? 23.94261  37.20070  -24.23304 1.000 38.25907  ? 398 ASP D N   1 
ATOM   2692 C CA  . ASP D 2 66  ? 24.06359  36.76966  -22.84829 1.000 35.06409  ? 398 ASP D CA  1 
ATOM   2693 C C   . ASP D 2 66  ? 24.04402  35.24688  -22.81006 1.000 36.14791  ? 398 ASP D C   1 
ATOM   2694 O O   . ASP D 2 66  ? 23.23797  34.61783  -23.50410 1.000 39.80050  ? 398 ASP D O   1 
ATOM   2695 C CB  . ASP D 2 66  ? 22.92930  37.34246  -21.99691 1.000 36.93949  ? 398 ASP D CB  1 
ATOM   2696 C CG  . ASP D 2 66  ? 22.83818  38.85966  -22.08029 1.000 42.66788  ? 398 ASP D CG  1 
ATOM   2697 O OD1 . ASP D 2 66  ? 23.88304  39.51245  -22.27372 1.000 39.03304  ? 398 ASP D OD1 1 
ATOM   2698 O OD2 . ASP D 2 66  ? 21.71800  39.40011  -21.94426 1.000 40.67466  ? 398 ASP D OD2 1 
ATOM   2699 N N   . SER D 2 67  ? 24.93215  34.65489  -22.01199 1.000 33.94021  ? 399 SER D N   1 
ATOM   2700 C CA  . SER D 2 67  ? 25.02779  33.20242  -21.93998 1.000 37.86205  ? 399 SER D CA  1 
ATOM   2701 C C   . SER D 2 67  ? 25.26937  32.76108  -20.50200 1.000 37.27955  ? 399 SER D C   1 
ATOM   2702 O O   . SER D 2 67  ? 25.87331  33.48426  -19.70460 1.000 35.63113  ? 399 SER D O   1 
ATOM   2703 C CB  . SER D 2 67  ? 26.13330  32.66029  -22.86518 1.000 33.41141  ? 399 SER D CB  1 
ATOM   2704 O OG  . SER D 2 67  ? 27.40087  33.20457  -22.54402 1.000 39.76744  ? 399 SER D OG  1 
ATOM   2705 N N   . PHE D 2 68  ? 24.77880  31.56443  -20.18242 1.000 39.78064  ? 400 PHE D N   1 
ATOM   2706 C CA  . PHE D 2 68  ? 24.82352  31.00269  -18.83275 1.000 37.74987  ? 400 PHE D CA  1 
ATOM   2707 C C   . PHE D 2 68  ? 24.27015  29.58038  -18.88771 1.000 37.07865  ? 400 PHE D C   1 
ATOM   2708 O O   . PHE D 2 68  ? 23.75882  29.13264  -19.91837 1.000 36.30782  ? 400 PHE D O   1 
ATOM   2709 C CB  . PHE D 2 68  ? 24.03496  31.86681  -17.84719 1.000 34.70154  ? 400 PHE D CB  1 
ATOM   2710 C CG  . PHE D 2 68  ? 22.64361  32.20410  -18.31677 1.000 39.10248  ? 400 PHE D CG  1 
ATOM   2711 C CD1 . PHE D 2 68  ? 21.59700  31.31510  -18.12675 1.000 33.23140  ? 400 PHE D CD1 1 
ATOM   2712 C CD2 . PHE D 2 68  ? 22.38426  33.40737  -18.95186 1.000 36.47611  ? 400 PHE D CD2 1 
ATOM   2713 C CE1 . PHE D 2 68  ? 20.32265  31.62307  -18.55412 1.000 32.54984  ? 400 PHE D CE1 1 
ATOM   2714 C CE2 . PHE D 2 68  ? 21.10828  33.71782  -19.38384 1.000 36.68916  ? 400 PHE D CE2 1 
ATOM   2715 C CZ  . PHE D 2 68  ? 20.07854  32.82482  -19.18539 1.000 35.45700  ? 400 PHE D CZ  1 
ATOM   2716 N N   . VAL D 2 69  ? 24.35892  28.87873  -17.75585 1.000 37.08831  ? 401 VAL D N   1 
ATOM   2717 C CA  . VAL D 2 69  ? 23.90418  27.49654  -17.62655 1.000 35.14776  ? 401 VAL D CA  1 
ATOM   2718 C C   . VAL D 2 69  ? 22.87518  27.42370  -16.50379 1.000 34.16227  ? 401 VAL D C   1 
ATOM   2719 O O   . VAL D 2 69  ? 23.09284  27.98142  -15.42254 1.000 31.03815  ? 401 VAL D O   1 
ATOM   2720 C CB  . VAL D 2 69  ? 25.07750  26.53565  -17.34475 1.000 35.74823  ? 401 VAL D CB  1 
ATOM   2721 C CG1 . VAL D 2 69  ? 24.56508  25.17965  -16.87458 1.000 33.90170  ? 401 VAL D CG1 1 
ATOM   2722 C CG2 . VAL D 2 69  ? 25.94552  26.37643  -18.57829 1.000 32.51069  ? 401 VAL D CG2 1 
ATOM   2723 N N   . ILE D 2 70  ? 21.75635  26.74001  -16.75887 1.000 34.77789  ? 402 ILE D N   1 
ATOM   2724 C CA  . ILE D 2 70  ? 20.70608  26.51649  -15.77003 1.000 32.94122  ? 402 ILE D CA  1 
ATOM   2725 C C   . ILE D 2 70  ? 20.18265  25.09125  -15.91827 1.000 33.63291  ? 402 ILE D C   1 
ATOM   2726 O O   . ILE D 2 70  ? 20.64868  24.31738  -16.75993 1.000 35.33375  ? 402 ILE D O   1 
ATOM   2727 C CB  . ILE D 2 70  ? 19.54919  27.53083  -15.89789 1.000 32.18953  ? 402 ILE D CB  1 
ATOM   2728 C CG1 . ILE D 2 70  ? 19.05405  27.61795  -17.34606 1.000 32.07240  ? 402 ILE D CG1 1 
ATOM   2729 C CG2 . ILE D 2 70  ? 19.96519  28.89120  -15.37312 1.000 29.12221  ? 402 ILE D CG2 1 
ATOM   2730 C CD1 . ILE D 2 70  ? 17.84170  28.51832  -17.51814 1.000 29.72144  ? 402 ILE D CD1 1 
ATOM   2731 N N   . ARG D 2 71  ? 19.20447  24.74514  -15.08198 1.000 32.11409  ? 403 ARG D N   1 
ATOM   2732 C CA  . ARG D 2 71  ? 18.53684  23.45408  -15.16714 1.000 37.79639  ? 403 ARG D CA  1 
ATOM   2733 C C   . ARG D 2 71  ? 17.54326  23.44172  -16.32436 1.000 34.42175  ? 403 ARG D C   1 
ATOM   2734 O O   . ARG D 2 71  ? 16.97431  24.47224  -16.69526 1.000 34.91447  ? 403 ARG D O   1 
ATOM   2735 C CB  . ARG D 2 71  ? 17.79443  23.12866  -13.86888 1.000 34.99939  ? 403 ARG D CB  1 
ATOM   2736 C CG  . ARG D 2 71  ? 18.66098  22.66493  -12.71710 1.000 33.13509  ? 403 ARG D CG  1 
ATOM   2737 C CD  . ARG D 2 71  ? 17.95884  22.92393  -11.38731 1.000 34.01026  ? 403 ARG D CD  1 
ATOM   2738 N NE  . ARG D 2 71  ? 16.60142  22.39232  -11.35787 1.000 31.11370  ? 403 ARG D NE  1 
ATOM   2739 C CZ  . ARG D 2 71  ? 15.79044  22.44772  -10.30956 1.000 36.12256  ? 403 ARG D CZ  1 
ATOM   2740 N NH1 . ARG D 2 71  ? 16.16704  23.00710  -9.16918  1.000 33.03697  ? 403 ARG D NH1 1 
ATOM   2741 N NH2 . ARG D 2 71  ? 14.57170  21.92439  -10.40631 1.000 37.08566  ? 403 ARG D NH2 1 
ATOM   2742 N N   . GLY D 2 72  ? 17.33284  22.24335  -16.88460 1.000 36.65058  ? 404 GLY D N   1 
ATOM   2743 C CA  . GLY D 2 72  ? 16.35033  22.08131  -17.94731 1.000 32.32659  ? 404 GLY D CA  1 
ATOM   2744 C C   . GLY D 2 72  ? 14.98797  22.64296  -17.59069 1.000 35.50682  ? 404 GLY D C   1 
ATOM   2745 O O   . GLY D 2 72  ? 14.38995  23.38532  -18.37308 1.000 34.59738  ? 404 GLY D O   1 
ATOM   2746 N N   . ASN D 2 73  ? 14.48882  22.32086  -16.39586 1.000 29.55302  ? 405 ASN D N   1 
ATOM   2747 C CA  . ASN D 2 73  ? 13.17406  22.81121  -15.99913 1.000 35.13182  ? 405 ASN D CA  1 
ATOM   2748 C C   . ASN D 2 73  ? 13.14638  24.31872  -15.79664 1.000 32.52498  ? 405 ASN D C   1 
ATOM   2749 O O   . ASN D 2 73  ? 12.05723  24.89229  -15.70718 1.000 36.65140  ? 405 ASN D O   1 
ATOM   2750 C CB  . ASN D 2 73  ? 12.71148  22.12560  -14.71405 1.000 27.69162  ? 405 ASN D CB  1 
ATOM   2751 C CG  . ASN D 2 73  ? 13.45096  22.63653  -13.49199 1.000 36.48307  ? 405 ASN D CG  1 
ATOM   2752 O OD1 . ASN D 2 73  ? 14.64373  22.38652  -13.33439 1.000 34.82007  ? 405 ASN D OD1 1 
ATOM   2753 N ND2 . ASN D 2 73  ? 12.74893  23.36385  -12.62529 1.000 37.63639  ? 405 ASN D ND2 1 
ATOM   2754 N N   . GLU D 2 74  ? 14.30318  24.96819  -15.71396 1.000 31.17670  ? 406 GLU D N   1 
ATOM   2755 C CA  . GLU D 2 74  ? 14.36261  26.41086  -15.53819 1.000 31.55722  ? 406 GLU D CA  1 
ATOM   2756 C C   . GLU D 2 74  ? 14.45323  27.17408  -16.85708 1.000 35.27231  ? 406 GLU D C   1 
ATOM   2757 O O   . GLU D 2 74  ? 14.34962  28.40594  -16.84885 1.000 34.38180  ? 406 GLU D O   1 
ATOM   2758 C CB  . GLU D 2 74  ? 15.55209  26.76996  -14.64167 1.000 29.72751  ? 406 GLU D CB  1 
ATOM   2759 C CG  . GLU D 2 74  ? 15.39752  26.28994  -13.19493 1.000 34.16713  ? 406 GLU D CG  1 
ATOM   2760 C CD  . GLU D 2 74  ? 16.70224  26.32279  -12.40759 1.000 37.49871  ? 406 GLU D CD  1 
ATOM   2761 O OE1 . GLU D 2 74  ? 17.78950  26.31279  -13.02878 1.000 34.17839  ? 406 GLU D OE1 1 
ATOM   2762 O OE2 . GLU D 2 74  ? 16.63597  26.35978  -11.15966 1.000 38.75550  ? 406 GLU D OE2 1 
ATOM   2763 N N   . VAL D 2 75  ? 14.63648  26.48103  -17.98497 1.000 31.24072  ? 407 VAL D N   1 
ATOM   2764 C CA  . VAL D 2 75  ? 14.79216  27.17472  -19.26309 1.000 35.96493  ? 407 VAL D CA  1 
ATOM   2765 C C   . VAL D 2 75  ? 13.55398  27.99918  -19.59208 1.000 36.94427  ? 407 VAL D C   1 
ATOM   2766 O O   . VAL D 2 75  ? 13.65983  29.09517  -20.15679 1.000 34.58694  ? 407 VAL D O   1 
ATOM   2767 C CB  . VAL D 2 75  ? 15.12354  26.16594  -20.38308 1.000 39.29465  ? 407 VAL D CB  1 
ATOM   2768 C CG1 . VAL D 2 75  ? 15.11573  26.84510  -21.74645 1.000 32.84348  ? 407 VAL D CG1 1 
ATOM   2769 C CG2 . VAL D 2 75  ? 16.48181  25.52395  -20.12689 1.000 33.05337  ? 407 VAL D CG2 1 
ATOM   2770 N N   . SER D 2 76  ? 12.37138  27.51378  -19.21018 1.000 36.58317  ? 408 SER D N   1 
ATOM   2771 C CA  . SER D 2 76  ? 11.13048  28.22752  -19.49224 1.000 35.43847  ? 408 SER D CA  1 
ATOM   2772 C C   . SER D 2 76  ? 11.05943  29.58622  -18.80109 1.000 41.26741  ? 408 SER D C   1 
ATOM   2773 O O   . SER D 2 76  ? 10.25692  30.43125  -19.21231 1.000 45.74805  ? 408 SER D O   1 
ATOM   2774 C CB  . SER D 2 76  ? 9.93381   27.37245  -19.07032 1.000 37.28013  ? 408 SER D CB  1 
ATOM   2775 O OG  . SER D 2 76  ? 10.04765  26.98628  -17.70249 1.000 39.99281  ? 408 SER D OG  1 
ATOM   2776 N N   . GLN D 2 77  ? 11.86906  29.81737  -17.75924 1.000 37.16956  ? 409 GLN D N   1 
ATOM   2777 C CA  . GLN D 2 77  ? 11.91012  31.12171  -17.10373 1.000 37.66834  ? 409 GLN D CA  1 
ATOM   2778 C C   . GLN D 2 77  ? 12.65840  32.17117  -17.91671 1.000 38.34639  ? 409 GLN D C   1 
ATOM   2779 O O   . GLN D 2 77  ? 12.56682  33.36011  -17.59310 1.000 41.28143  ? 409 GLN D O   1 
ATOM   2780 C CB  . GLN D 2 77  ? 12.56030  31.01395  -15.71478 1.000 34.22708  ? 409 GLN D CB  1 
ATOM   2781 C CG  . GLN D 2 77  ? 11.76894  30.21125  -14.68398 1.000 33.40417  ? 409 GLN D CG  1 
ATOM   2782 C CD  . GLN D 2 77  ? 12.45534  30.16457  -13.32207 1.000 37.70642  ? 409 GLN D CD  1 
ATOM   2783 O OE1 . GLN D 2 77  ? 12.97594  31.17041  -12.84071 1.000 34.17912  ? 409 GLN D OE1 1 
ATOM   2784 N NE2 . GLN D 2 77  ? 12.46146  28.98842  -12.69997 1.000 37.59221  ? 409 GLN D NE2 1 
ATOM   2785 N N   . ILE D 2 78  ? 13.40482  31.76960  -18.94646 1.000 36.48412  ? 410 ILE D N   1 
ATOM   2786 C CA  . ILE D 2 78  ? 14.13200  32.73482  -19.76472 1.000 41.28641  ? 410 ILE D CA  1 
ATOM   2787 C C   . ILE D 2 78  ? 13.20494  33.22173  -20.87080 1.000 41.25855  ? 410 ILE D C   1 
ATOM   2788 O O   . ILE D 2 78  ? 13.39359  32.89878  -22.04951 1.000 37.55443  ? 410 ILE D O   1 
ATOM   2789 C CB  . ILE D 2 78  ? 15.42967  32.13678  -20.33924 1.000 36.89177  ? 410 ILE D CB  1 
ATOM   2790 C CG1 . ILE D 2 78  ? 16.20432  31.38940  -19.24864 1.000 29.94839  ? 410 ILE D CG1 1 
ATOM   2791 C CG2 . ILE D 2 78  ? 16.29878  33.23995  -20.93562 1.000 31.65132  ? 410 ILE D CG2 1 
ATOM   2792 C CD1 . ILE D 2 78  ? 16.56019  32.25837  -18.05437 1.000 29.44866  ? 410 ILE D CD1 1 
ATOM   2793 N N   . ALA D 2 79  ? 12.19046  33.99564  -20.49250 1.000 39.40017  ? 411 ALA D N   1 
ATOM   2794 C CA  . ALA D 2 79  ? 11.17041  34.45347  -21.42425 1.000 42.47102  ? 411 ALA D CA  1 
ATOM   2795 C C   . ALA D 2 79  ? 10.48721  35.66319  -20.81239 1.000 43.68005  ? 411 ALA D C   1 
ATOM   2796 O O   . ALA D 2 79  ? 10.49136  35.81134  -19.58539 1.000 45.43430  ? 411 ALA D O   1 
ATOM   2797 C CB  . ALA D 2 79  ? 10.14881  33.34373  -21.71758 1.000 42.82539  ? 411 ALA D CB  1 
ATOM   2798 N N   . PRO D 2 80  ? 9.90721   36.54638  -21.62395 1.000 46.28195  ? 412 PRO D N   1 
ATOM   2799 C CA  . PRO D 2 80  ? 9.25012   37.72916  -21.05678 1.000 45.67626  ? 412 PRO D CA  1 
ATOM   2800 C C   . PRO D 2 80  ? 8.06891   37.33731  -20.18271 1.000 41.18638  ? 412 PRO D C   1 
ATOM   2801 O O   . PRO D 2 80  ? 7.32240   36.40797  -20.49473 1.000 48.64262  ? 412 PRO D O   1 
ATOM   2802 C CB  . PRO D 2 80  ? 8.80161   38.51803  -22.29501 1.000 48.12343  ? 412 PRO D CB  1 
ATOM   2803 C CG  . PRO D 2 80  ? 8.73040   37.50913  -23.38815 1.000 47.90449  ? 412 PRO D CG  1 
ATOM   2804 C CD  . PRO D 2 80  ? 9.82693   36.52587  -23.09516 1.000 50.27246  ? 412 PRO D CD  1 
ATOM   2805 N N   . GLY D 2 81  ? 7.91895   38.04883  -19.07076 1.000 43.31060  ? 413 GLY D N   1 
ATOM   2806 C CA  . GLY D 2 81  ? 6.79030   37.84836  -18.17725 1.000 46.64365  ? 413 GLY D CA  1 
ATOM   2807 C C   . GLY D 2 81  ? 6.82623   36.57604  -17.35685 1.000 52.47960  ? 413 GLY D C   1 
ATOM   2808 O O   . GLY D 2 81  ? 5.76750   36.01100  -17.05342 1.000 53.22735  ? 413 GLY D O   1 
ATOM   2809 N N   . GLN D 2 82  ? 8.01417   36.11426  -16.98061 1.000 48.33508  ? 414 GLN D N   1 
ATOM   2810 C CA  . GLN D 2 82  ? 8.16958   34.88992  -16.21273 1.000 46.04534  ? 414 GLN D CA  1 
ATOM   2811 C C   . GLN D 2 82  ? 8.61568   35.20384  -14.79197 1.000 42.39068  ? 414 GLN D C   1 
ATOM   2812 O O   . GLN D 2 82  ? 9.29293   36.20394  -14.54027 1.000 47.74391  ? 414 GLN D O   1 
ATOM   2813 C CB  . GLN D 2 82  ? 9.17964   33.95121  -16.87750 1.000 47.96540  ? 414 GLN D CB  1 
ATOM   2814 C CG  . GLN D 2 82  ? 8.66936   33.32003  -18.15830 1.000 50.04662  ? 414 GLN D CG  1 
ATOM   2815 C CD  . GLN D 2 82  ? 7.56156   32.32430  -17.89869 1.000 54.47989  ? 414 GLN D CD  1 
ATOM   2816 O OE1 . GLN D 2 82  ? 7.54577   31.65763  -16.86497 1.000 56.67394  ? 414 GLN D OE1 1 
ATOM   2817 N NE2 . GLN D 2 82  ? 6.62574   32.21816  -18.83447 1.000 60.65562  ? 414 GLN D NE2 1 
ATOM   2818 N N   . THR D 2 83  ? 8.21794   34.34140  -13.86273 1.000 42.70151  ? 415 THR D N   1 
ATOM   2819 C CA  . THR D 2 83  ? 8.70014   34.38510  -12.49285 1.000 38.02491  ? 415 THR D CA  1 
ATOM   2820 C C   . THR D 2 83  ? 9.31563   33.04065  -12.13112 1.000 36.16075  ? 415 THR D C   1 
ATOM   2821 O O   . THR D 2 83  ? 9.07904   32.02582  -12.79126 1.000 40.41078  ? 415 THR D O   1 
ATOM   2822 C CB  . THR D 2 83  ? 7.57909   34.72473  -11.49705 1.000 45.82586  ? 415 THR D CB  1 
ATOM   2823 O OG1 . THR D 2 83  ? 6.49814   33.79828  -11.65512 1.000 54.50384  ? 415 THR D OG1 1 
ATOM   2824 C CG2 . THR D 2 83  ? 7.07101   36.14006  -11.71980 1.000 46.96124  ? 415 THR D CG2 1 
ATOM   2825 N N   . GLY D 2 84  ? 10.09976  33.04186  -11.06996 1.000 39.43795  ? 416 GLY D N   1 
ATOM   2826 C CA  . GLY D 2 84  ? 10.76229  31.83584  -10.61580 1.000 39.43725  ? 416 GLY D CA  1 
ATOM   2827 C C   . GLY D 2 84  ? 12.08756  32.18384  -9.97262  1.000 41.13990  ? 416 GLY D C   1 
ATOM   2828 O O   . GLY D 2 84  ? 12.47243  33.34507  -9.87625  1.000 37.16086  ? 416 GLY D O   1 
ATOM   2829 N N   . ASN D 2 85  ? 12.78487  31.13642  -9.52533  1.000 39.42476  ? 417 ASN D N   1 
ATOM   2830 C CA  . ASN D 2 85  ? 14.07048  31.35431  -8.87199  1.000 36.96449  ? 417 ASN D CA  1 
ATOM   2831 C C   . ASN D 2 85  ? 15.07213  32.01598  -9.81464  1.000 38.99003  ? 417 ASN D C   1 
ATOM   2832 O O   . ASN D 2 85  ? 15.85513  32.87025  -9.38392  1.000 40.01057  ? 417 ASN D O   1 
ATOM   2833 C CB  . ASN D 2 85  ? 14.62254  30.03164  -8.32823  1.000 33.53590  ? 417 ASN D CB  1 
ATOM   2834 C CG  . ASN D 2 85  ? 14.90026  29.01106  -9.42275  1.000 37.37916  ? 417 ASN D CG  1 
ATOM   2835 O OD1 . ASN D 2 85  ? 14.09711  28.82861  -10.33849 1.000 38.24828  ? 417 ASN D OD1 1 
ATOM   2836 N ND2 . ASN D 2 85  ? 16.04509  28.34237  -9.33161  1.000 38.77036  ? 417 ASN D ND2 1 
ATOM   2837 N N   . ILE D 2 86  ? 15.04981  31.66076  -11.10023 1.000 35.19282  ? 418 ILE D N   1 
ATOM   2838 C CA  . ILE D 2 86  ? 16.01678  32.22535  -12.03801 1.000 38.36842  ? 418 ILE D CA  1 
ATOM   2839 C C   . ILE D 2 86  ? 15.59206  33.62075  -12.47902 1.000 38.99019  ? 418 ILE D C   1 
ATOM   2840 O O   . ILE D 2 86  ? 16.38815  34.56562  -12.44578 1.000 34.52677  ? 418 ILE D O   1 
ATOM   2841 C CB  . ILE D 2 86  ? 16.21144  31.29007  -13.24697 1.000 32.13997  ? 418 ILE D CB  1 
ATOM   2842 C CG1 . ILE D 2 86  ? 16.71984  29.91647  -12.79659 1.000 31.70106  ? 418 ILE D CG1 1 
ATOM   2843 C CG2 . ILE D 2 86  ? 17.17075  31.92045  -14.25391 1.000 31.33854  ? 418 ILE D CG2 1 
ATOM   2844 C CD1 . ILE D 2 86  ? 17.97220  29.97633  -11.93650 1.000 31.07676  ? 418 ILE D CD1 1 
ATOM   2845 N N   . ALA D 2 87  ? 14.33683  33.76998  -12.91191 1.000 34.09259  ? 419 ALA D N   1 
ATOM   2846 C CA  . ALA D 2 87  ? 13.86543  35.06951  -13.38284 1.000 37.09587  ? 419 ALA D CA  1 
ATOM   2847 C C   . ALA D 2 87  ? 13.89391  36.12645  -12.28253 1.000 40.54379  ? 419 ALA D C   1 
ATOM   2848 O O   . ALA D 2 87  ? 14.17469  37.29768  -12.55963 1.000 38.56824  ? 419 ALA D O   1 
ATOM   2849 C CB  . ALA D 2 87  ? 12.45377  34.93855  -13.95156 1.000 36.43180  ? 419 ALA D CB  1 
ATOM   2850 N N   . ASP D 2 88  ? 13.61393  35.74000  -11.03602 1.000 38.18513  ? 420 ASP D N   1 
ATOM   2851 C CA  . ASP D 2 88  ? 13.56208  36.71668  -9.95222  1.000 37.19838  ? 420 ASP D CA  1 
ATOM   2852 C C   . ASP D 2 88  ? 14.94772  37.08865  -9.44251  1.000 36.90363  ? 420 ASP D C   1 
ATOM   2853 O O   . ASP D 2 88  ? 15.19743  38.25443  -9.12429  1.000 40.47975  ? 420 ASP D O   1 
ATOM   2854 C CB  . ASP D 2 88  ? 12.73237  36.18397  -8.78150  1.000 43.11990  ? 420 ASP D CB  1 
ATOM   2855 C CG  . ASP D 2 88  ? 11.26575  36.03406  -9.11585  1.000 44.04167  ? 420 ASP D CG  1 
ATOM   2856 O OD1 . ASP D 2 88  ? 10.87541  36.31909  -10.26805 1.000 42.07920  ? 420 ASP D OD1 1 
ATOM   2857 O OD2 . ASP D 2 88  ? 10.50310  35.62919  -8.21386  1.000 44.17258  ? 420 ASP D OD2 1 
ATOM   2858 N N   . TYR D 2 89  ? 15.85016  36.11707  -9.31837  1.000 36.24854  ? 421 TYR D N   1 
ATOM   2859 C CA  . TYR D 2 89  ? 17.08115  36.32366  -8.56851  1.000 37.37494  ? 421 TYR D CA  1 
ATOM   2860 C C   . TYR D 2 89  ? 18.34594  36.20756  -9.40426  1.000 41.40300  ? 421 TYR D C   1 
ATOM   2861 O O   . TYR D 2 89  ? 19.43576  36.46210  -8.87735  1.000 42.44030  ? 421 TYR D O   1 
ATOM   2862 C CB  . TYR D 2 89  ? 17.16874  35.32893  -7.39980  1.000 37.19952  ? 421 TYR D CB  1 
ATOM   2863 C CG  . TYR D 2 89  ? 16.04122  35.42611  -6.39355  1.000 39.83793  ? 421 TYR D CG  1 
ATOM   2864 C CD1 . TYR D 2 89  ? 15.26669  36.57448  -6.28804  1.000 41.56336  ? 421 TYR D CD1 1 
ATOM   2865 C CD2 . TYR D 2 89  ? 15.76046  34.36842  -5.53797  1.000 41.40957  ? 421 TYR D CD2 1 
ATOM   2866 C CE1 . TYR D 2 89  ? 14.24029  36.66417  -5.37046  1.000 41.32419  ? 421 TYR D CE1 1 
ATOM   2867 C CE2 . TYR D 2 89  ? 14.73521  34.45022  -4.61317  1.000 44.76249  ? 421 TYR D CE2 1 
ATOM   2868 C CZ  . TYR D 2 89  ? 13.97926  35.59920  -4.53431  1.000 44.84085  ? 421 TYR D CZ  1 
ATOM   2869 O OH  . TYR D 2 89  ? 12.95817  35.67931  -3.61479  1.000 46.75596  ? 421 TYR D OH  1 
ATOM   2870 N N   . ASN D 2 90  ? 18.24615  35.84310  -10.68216 1.000 36.28383  ? 422 ASN D N   1 
ATOM   2871 C CA  . ASN D 2 90  ? 19.44867  35.52055  -11.43981 1.000 36.93851  ? 422 ASN D CA  1 
ATOM   2872 C C   . ASN D 2 90  ? 19.50414  36.22229  -12.79482 1.000 37.21411  ? 422 ASN D C   1 
ATOM   2873 O O   . ASN D 2 90  ? 20.42859  36.99921  -13.04438 1.000 37.42667  ? 422 ASN D O   1 
ATOM   2874 C CB  . ASN D 2 90  ? 19.55845  34.00247  -11.60187 1.000 33.92351  ? 422 ASN D CB  1 
ATOM   2875 C CG  . ASN D 2 90  ? 19.82808  33.29384  -10.27626 1.000 37.33379  ? 422 ASN D CG  1 
ATOM   2876 O OD1 . ASN D 2 90  ? 20.98082  33.10105  -9.88652  1.000 35.01068  ? 422 ASN D OD1 1 
ATOM   2877 N ND2 . ASN D 2 90  ? 18.76223  32.91298  -9.57528  1.000 37.79406  ? 422 ASN D ND2 1 
ATOM   2878 N N   . TYR D 2 91  ? 18.53788  35.96805  -13.67620 1.000 36.04311  ? 423 TYR D N   1 
ATOM   2879 C CA  . TYR D 2 91  ? 18.52362  36.58340  -15.00089 1.000 36.32834  ? 423 TYR D CA  1 
ATOM   2880 C C   . TYR D 2 91  ? 17.08951  36.90832  -15.38958 1.000 37.13529  ? 423 TYR D C   1 
ATOM   2881 O O   . TYR D 2 91  ? 16.25824  36.00452  -15.50991 1.000 41.25705  ? 423 TYR D O   1 
ATOM   2882 C CB  . TYR D 2 91  ? 19.16562  35.66568  -16.04613 1.000 34.19555  ? 423 TYR D CB  1 
ATOM   2883 C CG  . TYR D 2 91  ? 19.28472  36.30627  -17.41002 1.000 35.99498  ? 423 TYR D CG  1 
ATOM   2884 C CD1 . TYR D 2 91  ? 20.34372  37.15456  -17.71059 1.000 36.47179  ? 423 TYR D CD1 1 
ATOM   2885 C CD2 . TYR D 2 91  ? 18.33486  36.07163  -18.39336 1.000 33.34472  ? 423 TYR D CD2 1 
ATOM   2886 C CE1 . TYR D 2 91  ? 20.44876  37.74874  -18.95828 1.000 37.26648  ? 423 TYR D CE1 1 
ATOM   2887 C CE2 . TYR D 2 91  ? 18.43081  36.66300  -19.64000 1.000 35.72172  ? 423 TYR D CE2 1 
ATOM   2888 C CZ  . TYR D 2 91  ? 19.48891  37.49815  -19.91934 1.000 37.49601  ? 423 TYR D CZ  1 
ATOM   2889 O OH  . TYR D 2 91  ? 19.58896  38.08442  -21.16288 1.000 41.81167  ? 423 TYR D OH  1 
ATOM   2890 N N   . LYS D 2 92  ? 16.80648  38.18845  -15.61440 1.000 38.88553  ? 424 LYS D N   1 
ATOM   2891 C CA  . LYS D 2 92  ? 15.45174  38.66484  -15.86302 1.000 39.05821  ? 424 LYS D CA  1 
ATOM   2892 C C   . LYS D 2 92  ? 15.35293  39.29500  -17.24509 1.000 42.01026  ? 424 LYS D C   1 
ATOM   2893 O O   . LYS D 2 92  ? 16.11214  40.21284  -17.56977 1.000 44.94275  ? 424 LYS D O   1 
ATOM   2894 C CB  . LYS D 2 92  ? 15.02845  39.67671  -14.79618 1.000 40.34076  ? 424 LYS D CB  1 
ATOM   2895 C CG  . LYS D 2 92  ? 13.62330  40.22960  -14.98454 1.000 44.59842  ? 424 LYS D CG  1 
ATOM   2896 C CD  . LYS D 2 92  ? 12.58120  39.11974  -15.01612 1.000 42.95507  ? 424 LYS D CD  1 
ATOM   2897 C CE  . LYS D 2 92  ? 11.17353  39.69310  -14.99853 1.000 45.54921  ? 424 LYS D CE  1 
ATOM   2898 N NZ  . LYS D 2 92  ? 10.13634  38.65112  -15.22181 1.000 48.63515  ? 424 LYS D NZ  1 
ATOM   2899 N N   . LEU D 2 93  ? 14.41383  38.79943  -18.05576 1.000 41.43033  ? 425 LEU D N   1 
ATOM   2900 C CA  . LEU D 2 93  ? 14.08335  39.42366  -19.32574 1.000 40.48741  ? 425 LEU D CA  1 
ATOM   2901 C C   . LEU D 2 93  ? 12.95553  40.43473  -19.14099 1.000 52.95220  ? 425 LEU D C   1 
ATOM   2902 O O   . LEU D 2 93  ? 12.07145  40.24060  -18.29920 1.000 54.45938  ? 425 LEU D O   1 
ATOM   2903 C CB  . LEU D 2 93  ? 13.66151  38.37249  -20.34760 1.000 39.93607  ? 425 LEU D CB  1 
ATOM   2904 C CG  . LEU D 2 93  ? 14.75971  37.51795  -20.98020 1.000 40.51588  ? 425 LEU D CG  1 
ATOM   2905 C CD1 . LEU D 2 93  ? 14.16142  36.58076  -22.01597 1.000 37.65241  ? 425 LEU D CD1 1 
ATOM   2906 C CD2 . LEU D 2 93  ? 15.83247  38.39560  -21.60248 1.000 37.33256  ? 425 LEU D CD2 1 
ATOM   2907 N N   . PRO D 2 94  ? 12.96819  41.52445  -19.90651 1.000 48.43625  ? 426 PRO D N   1 
ATOM   2908 C CA  . PRO D 2 94  ? 11.88048  42.50259  -19.81596 1.000 48.83121  ? 426 PRO D CA  1 
ATOM   2909 C C   . PRO D 2 94  ? 10.61555  41.98509  -20.48433 1.000 50.92923  ? 426 PRO D C   1 
ATOM   2910 O O   . PRO D 2 94  ? 10.64827  41.11466  -21.35783 1.000 47.70405  ? 426 PRO D O   1 
ATOM   2911 C CB  . PRO D 2 94  ? 12.44145  43.71977  -20.55697 1.000 53.28718  ? 426 PRO D CB  1 
ATOM   2912 C CG  . PRO D 2 94  ? 13.36677  43.11962  -21.57035 1.000 48.15188  ? 426 PRO D CG  1 
ATOM   2913 C CD  . PRO D 2 94  ? 13.99573  41.93265  -20.88095 1.000 49.37956  ? 426 PRO D CD  1 
ATOM   2914 N N   . ASP D 2 95  ? 9.48020   42.54530  -20.05450 1.000 51.99090  ? 427 ASP D N   1 
ATOM   2915 C CA  . ASP D 2 95  ? 8.19673   42.13755  -20.61742 1.000 50.46017  ? 427 ASP D CA  1 
ATOM   2916 C C   . ASP D 2 95  ? 8.11185   42.43246  -22.11042 1.000 49.56836  ? 427 ASP D C   1 
ATOM   2917 O O   . ASP D 2 95  ? 7.47966   41.67419  -22.85311 1.000 51.86586  ? 427 ASP D O   1 
ATOM   2918 C CB  . ASP D 2 95  ? 7.05000   42.82923  -19.87810 1.000 53.22275  ? 427 ASP D CB  1 
ATOM   2919 C CG  . ASP D 2 95  ? 6.93656   42.39093  -18.43085 1.000 63.37502  ? 427 ASP D CG  1 
ATOM   2920 O OD1 . ASP D 2 95  ? 7.73319   41.53246  -17.99903 1.000 65.39854  ? 427 ASP D OD1 1 
ATOM   2921 O OD2 . ASP D 2 95  ? 6.05030   42.90570  -17.72001 1.000 70.04204  ? 427 ASP D OD2 1 
ATOM   2922 N N   . ASP D 2 96  ? 8.73899   43.51598  -22.57161 1.000 49.41826  ? 428 ASP D N   1 
ATOM   2923 C CA  . ASP D 2 96  ? 8.71815   43.88619  -23.98221 1.000 56.03951  ? 428 ASP D CA  1 
ATOM   2924 C C   . ASP D 2 96  ? 9.88470   43.29234  -24.76731 1.000 54.33950  ? 428 ASP D C   1 
ATOM   2925 O O   . ASP D 2 96  ? 10.30102  43.86765  -25.78220 1.000 59.36064  ? 428 ASP D O   1 
ATOM   2926 C CB  . ASP D 2 96  ? 8.69850   45.40996  -24.12225 1.000 45.53629  ? 428 ASP D CB  1 
ATOM   2927 C CG  . ASP D 2 96  ? 9.88817   46.07705  -23.45336 1.000 55.90837  ? 428 ASP D CG  1 
ATOM   2928 O OD1 . ASP D 2 96  ? 10.73013  45.36590  -22.86796 1.000 62.76001  ? 428 ASP D OD1 1 
ATOM   2929 O OD2 . ASP D 2 96  ? 9.98129   47.32044  -23.50924 1.000 62.89409  ? 428 ASP D OD2 1 
ATOM   2930 N N   . PHE D 2 97  ? 10.42415  42.15995  -24.32440 1.000 50.12605  ? 429 PHE D N   1 
ATOM   2931 C CA  . PHE D 2 97  ? 11.57546  41.56426  -24.98885 1.000 49.85391  ? 429 PHE D CA  1 
ATOM   2932 C C   . PHE D 2 97  ? 11.20349  41.13152  -26.40096 1.000 50.15221  ? 429 PHE D C   1 
ATOM   2933 O O   . PHE D 2 97  ? 10.15031  40.52607  -26.61991 1.000 48.09407  ? 429 PHE D O   1 
ATOM   2934 C CB  . PHE D 2 97  ? 12.08917  40.37304  -24.17947 1.000 47.97717  ? 429 PHE D CB  1 
ATOM   2935 C CG  . PHE D 2 97  ? 13.30199  39.70572  -24.76937 1.000 44.61489  ? 429 PHE D CG  1 
ATOM   2936 C CD1 . PHE D 2 97  ? 14.54617  40.31857  -24.71237 1.000 45.19405  ? 429 PHE D CD1 1 
ATOM   2937 C CD2 . PHE D 2 97  ? 13.20157  38.45523  -25.36180 1.000 43.49334  ? 429 PHE D CD2 1 
ATOM   2938 C CE1 . PHE D 2 97  ? 15.66481  39.70362  -25.24732 1.000 41.80290  ? 429 PHE D CE1 1 
ATOM   2939 C CE2 . PHE D 2 97  ? 14.31654  37.83264  -25.89630 1.000 42.17467  ? 429 PHE D CE2 1 
ATOM   2940 C CZ  . PHE D 2 97  ? 15.55090  38.45694  -25.83496 1.000 37.30391  ? 429 PHE D CZ  1 
ATOM   2941 N N   . THR D 2 98  ? 12.07047  41.45194  -27.36507 1.000 47.89236  ? 430 THR D N   1 
ATOM   2942 C CA  . THR D 2 98  ? 11.81824  41.13005  -28.76500 1.000 54.09740  ? 430 THR D CA  1 
ATOM   2943 C C   . THR D 2 98  ? 13.00248  40.41726  -29.41063 1.000 53.39454  ? 430 THR D C   1 
ATOM   2944 O O   . THR D 2 98  ? 13.07698  40.34472  -30.64172 1.000 51.81085  ? 430 THR D O   1 
ATOM   2945 C CB  . THR D 2 98  ? 11.46688  42.39193  -29.56291 1.000 56.28953  ? 430 THR D CB  1 
ATOM   2946 O OG1 . THR D 2 98  ? 12.52703  43.34785  -29.44383 1.000 57.20817  ? 430 THR D OG1 1 
ATOM   2947 C CG2 . THR D 2 98  ? 10.17145  43.01043  -29.04796 1.000 44.73657  ? 430 THR D CG2 1 
ATOM   2948 N N   . GLY D 2 99  ? 13.92856  39.89372  -28.61396 1.000 47.23644  ? 431 GLY D N   1 
ATOM   2949 C CA  . GLY D 2 99  ? 15.06121  39.15008  -29.12494 1.000 43.39030  ? 431 GLY D CA  1 
ATOM   2950 C C   . GLY D 2 99  ? 14.77655  37.66591  -29.22678 1.000 44.22211  ? 431 GLY D C   1 
ATOM   2951 O O   . GLY D 2 99  ? 13.62495  37.22471  -29.26402 1.000 49.61619  ? 431 GLY D O   1 
ATOM   2952 N N   . CYS D 2 100 ? 15.85175  36.88283  -29.26812 1.000 42.20835  ? 432 CYS D N   1 
ATOM   2953 C CA  . CYS D 2 100 ? 15.75626  35.43664  -29.38959 1.000 43.05523  ? 432 CYS D CA  1 
ATOM   2954 C C   . CYS D 2 100 ? 16.45816  34.75862  -28.21930 1.000 44.75624  ? 432 CYS D C   1 
ATOM   2955 O O   . CYS D 2 100 ? 17.44258  35.27184  -27.67929 1.000 38.67319  ? 432 CYS D O   1 
ATOM   2956 C CB  . CYS D 2 100 ? 16.36425  34.94654  -30.71010 1.000 43.12895  ? 432 CYS D CB  1 
ATOM   2957 S SG  . CYS D 2 100 ? 15.71574  35.75539  -32.19650 1.000 66.42953  ? 432 CYS D SG  1 
ATOM   2958 N N   . VAL D 2 101 ? 15.93508  33.59620  -27.83601 1.000 41.64728  ? 433 VAL D N   1 
ATOM   2959 C CA  . VAL D 2 101 ? 16.48646  32.77364  -26.76368 1.000 37.07123  ? 433 VAL D CA  1 
ATOM   2960 C C   . VAL D 2 101 ? 16.77479  31.39155  -27.33462 1.000 38.27026  ? 433 VAL D C   1 
ATOM   2961 O O   . VAL D 2 101 ? 15.87414  30.74222  -27.87760 1.000 38.98269  ? 433 VAL D O   1 
ATOM   2962 C CB  . VAL D 2 101 ? 15.52849  32.67800  -25.56698 1.000 39.81869  ? 433 VAL D CB  1 
ATOM   2963 C CG1 . VAL D 2 101 ? 16.10966  31.75950  -24.49669 1.000 36.54239  ? 433 VAL D CG1 1 
ATOM   2964 C CG2 . VAL D 2 101 ? 15.24644  34.05904  -24.99875 1.000 37.72822  ? 433 VAL D CG2 1 
ATOM   2965 N N   . ILE D 2 102 ? 18.02536  30.94935  -27.21906 1.000 37.46139  ? 434 ILE D N   1 
ATOM   2966 C CA  . ILE D 2 102 ? 18.47034  29.65151  -27.71306 1.000 36.76363  ? 434 ILE D CA  1 
ATOM   2967 C C   . ILE D 2 102 ? 18.97483  28.84340  -26.52584 1.000 36.95798  ? 434 ILE D C   1 
ATOM   2968 O O   . ILE D 2 102 ? 19.75568  29.35310  -25.71495 1.000 36.42919  ? 434 ILE D O   1 
ATOM   2969 C CB  . ILE D 2 102 ? 19.57494  29.79620  -28.77730 1.000 41.12370  ? 434 ILE D CB  1 
ATOM   2970 C CG1 . ILE D 2 102 ? 19.11383  30.69830  -29.92577 1.000 43.79692  ? 434 ILE D CG1 1 
ATOM   2971 C CG2 . ILE D 2 102 ? 19.99825  28.42928  -29.30389 1.000 37.21793  ? 434 ILE D CG2 1 
ATOM   2972 C CD1 . ILE D 2 102 ? 19.55472  32.13971  -29.79479 1.000 42.77919  ? 434 ILE D CD1 1 
ATOM   2973 N N   . ALA D 2 103 ? 18.53278  27.58901  -26.42403 1.000 41.16038  ? 435 ALA D N   1 
ATOM   2974 C CA  . ALA D 2 103 ? 18.93318  26.71256  -25.32917 1.000 40.58485  ? 435 ALA D CA  1 
ATOM   2975 C C   . ALA D 2 103 ? 19.12557  25.29326  -25.84268 1.000 40.56900  ? 435 ALA D C   1 
ATOM   2976 O O   . ALA D 2 103 ? 18.36360  24.82702  -26.69358 1.000 41.31554  ? 435 ALA D O   1 
ATOM   2977 C CB  . ALA D 2 103 ? 17.90020  26.71433  -24.19233 1.000 30.40057  ? 435 ALA D CB  1 
ATOM   2978 N N   . TRP D 2 104 ? 20.14251  24.60759  -25.31698 1.000 39.96528  ? 436 TRP D N   1 
ATOM   2979 C CA  . TRP D 2 104 ? 20.39377  23.22176  -25.68622 1.000 40.75052  ? 436 TRP D CA  1 
ATOM   2980 C C   . TRP D 2 104 ? 20.96384  22.46182  -24.49560 1.000 38.82761  ? 436 TRP D C   1 
ATOM   2981 O O   . TRP D 2 104 ? 21.56654  23.04240  -23.58877 1.000 35.81170  ? 436 TRP D O   1 
ATOM   2982 C CB  . TRP D 2 104 ? 21.33753  23.11923  -26.88876 1.000 36.47494  ? 436 TRP D CB  1 
ATOM   2983 C CG  . TRP D 2 104 ? 22.73106  23.61074  -26.64240 1.000 42.10520  ? 436 TRP D CG  1 
ATOM   2984 C CD1 . TRP D 2 104 ? 23.82952  22.85241  -26.35293 1.000 43.17474  ? 436 TRP D CD1 1 
ATOM   2985 C CD2 . TRP D 2 104 ? 23.18329  24.97018  -26.68204 1.000 43.14164  ? 436 TRP D CD2 1 
ATOM   2986 N NE1 . TRP D 2 104 ? 24.93613  23.65526  -26.20501 1.000 35.13721  ? 436 TRP D NE1 1 
ATOM   2987 C CE2 . TRP D 2 104 ? 24.56678  24.95933  -26.40245 1.000 43.82654  ? 436 TRP D CE2 1 
ATOM   2988 C CE3 . TRP D 2 104 ? 22.55086  26.19676  -26.91241 1.000 37.67850  ? 436 TRP D CE3 1 
ATOM   2989 C CZ2 . TRP D 2 104 ? 25.32910  26.12538  -26.35946 1.000 43.00729  ? 436 TRP D CZ2 1 
ATOM   2990 C CZ3 . TRP D 2 104 ? 23.31003  27.35114  -26.87688 1.000 40.76230  ? 436 TRP D CZ3 1 
ATOM   2991 C CH2 . TRP D 2 104 ? 24.68390  27.30737  -26.59841 1.000 47.08706  ? 436 TRP D CH2 1 
ATOM   2992 N N   . ASN D 2 105 ? 20.76652  21.14416  -24.52251 1.000 35.72892  ? 437 ASN D N   1 
ATOM   2993 C CA  . ASN D 2 105 ? 21.23044  20.26708  -23.45418 1.000 39.53775  ? 437 ASN D CA  1 
ATOM   2994 C C   . ASN D 2 105 ? 22.75120  20.15530  -23.47933 1.000 38.00686  ? 437 ASN D C   1 
ATOM   2995 O O   . ASN D 2 105 ? 23.34270  19.86808  -24.52277 1.000 39.59049  ? 437 ASN D O   1 
ATOM   2996 C CB  . ASN D 2 105 ? 20.59483  18.88523  -23.61236 1.000 40.01902  ? 437 ASN D CB  1 
ATOM   2997 C CG  . ASN D 2 105 ? 20.89193  17.96071  -22.44487 1.000 40.94262  ? 437 ASN D CG  1 
ATOM   2998 O OD1 . ASN D 2 105 ? 22.02938  17.53603  -22.24385 1.000 35.76414  ? 437 ASN D OD1 1 
ATOM   2999 N ND2 . ASN D 2 105 ? 19.85857  17.62504  -21.68205 1.000 36.27020  ? 437 ASN D ND2 1 
ATOM   3000 N N   . SER D 2 106 ? 23.38994  20.36911  -22.32929 1.000 38.39023  ? 438 SER D N   1 
ATOM   3001 C CA  . SER D 2 106 ? 24.84687  20.30225  -22.24297 1.000 42.37675  ? 438 SER D CA  1 
ATOM   3002 C C   . SER D 2 106 ? 25.28992  19.29908  -21.18611 1.000 37.99099  ? 438 SER D C   1 
ATOM   3003 O O   . SER D 2 106 ? 26.28560  19.50664  -20.48509 1.000 40.23455  ? 438 SER D O   1 
ATOM   3004 C CB  . SER D 2 106 ? 25.44363  21.67823  -21.96453 1.000 39.44924  ? 438 SER D CB  1 
ATOM   3005 O OG  . SER D 2 106 ? 25.01437  22.18069  -20.71353 1.000 36.37963  ? 438 SER D OG  1 
ATOM   3006 N N   . ASN D 2 107 ? 24.56095  18.18346  -21.07347 1.000 41.26023  ? 439 ASN D N   1 
ATOM   3007 C CA  . ASN D 2 107 ? 24.92492  17.13655  -20.11912 1.000 40.88449  ? 439 ASN D CA  1 
ATOM   3008 C C   . ASN D 2 107 ? 26.34289  16.62695  -20.36476 1.000 42.34973  ? 439 ASN D C   1 
ATOM   3009 O O   . ASN D 2 107 ? 27.12269  16.45664  -19.41911 1.000 42.09886  ? 439 ASN D O   1 
ATOM   3010 C CB  . ASN D 2 107 ? 23.91677  15.98814  -20.20499 1.000 35.91288  ? 439 ASN D CB  1 
ATOM   3011 C CG  . ASN D 2 107 ? 23.93649  15.08845  -18.98044 1.000 46.15119  ? 439 ASN D CG  1 
ATOM   3012 O OD1 . ASN D 2 107 ? 24.01456  15.55922  -17.84237 1.000 35.56360  ? 439 ASN D OD1 1 
ATOM   3013 N ND2 . ASN D 2 107 ? 23.85824  13.78132  -19.21145 1.000 44.66429  ? 439 ASN D ND2 1 
ATOM   3014 N N   . LYS D 2 108 ? 26.70226  16.39900  -21.63202 1.000 41.11963  ? 440 LYS D N   1 
ATOM   3015 C CA  . LYS D 2 108 ? 28.02560  15.86729  -21.94500 1.000 48.59470  ? 440 LYS D CA  1 
ATOM   3016 C C   . LYS D 2 108 ? 29.13866  16.82141  -21.52871 1.000 47.24556  ? 440 LYS D C   1 
ATOM   3017 O O   . LYS D 2 108 ? 30.21789  16.37162  -21.12700 1.000 52.92816  ? 440 LYS D O   1 
ATOM   3018 C CB  . LYS D 2 108 ? 28.13054  15.55635  -23.44053 1.000 50.03475  ? 440 LYS D CB  1 
ATOM   3019 C CG  . LYS D 2 108 ? 27.16376  14.48482  -23.92554 1.000 60.47950  ? 440 LYS D CG  1 
ATOM   3020 C CD  . LYS D 2 108 ? 27.33674  14.20189  -25.41518 1.000 75.06127  ? 440 LYS D CD  1 
ATOM   3021 C CE  . LYS D 2 108 ? 26.34593  13.14516  -25.89895 1.000 73.87109  ? 440 LYS D CE  1 
ATOM   3022 N NZ  . LYS D 2 108 ? 24.92780  13.55258  -25.66108 1.000 74.18529  ? 440 LYS D NZ  1 
ATOM   3023 N N   . LEU D 2 109 ? 28.89754  18.12990  -21.60121 1.000 45.43578  ? 441 LEU D N   1 
ATOM   3024 C CA  . LEU D 2 109 ? 29.93958  19.11319  -21.32724 1.000 46.13116  ? 441 LEU D CA  1 
ATOM   3025 C C   . LEU D 2 109 ? 29.97738  19.55442  -19.87016 1.000 44.06993  ? 441 LEU D C   1 
ATOM   3026 O O   . LEU D 2 109 ? 31.06168  19.77193  -19.32185 1.000 44.56488  ? 441 LEU D O   1 
ATOM   3027 C CB  . LEU D 2 109 ? 29.74677  20.34639  -22.21438 1.000 48.36414  ? 441 LEU D CB  1 
ATOM   3028 C CG  . LEU D 2 109 ? 29.65795  20.09168  -23.71650 1.000 49.65736  ? 441 LEU D CG  1 
ATOM   3029 C CD1 . LEU D 2 109 ? 29.20155  21.34654  -24.44167 1.000 51.38677  ? 441 LEU D CD1 1 
ATOM   3030 C CD2 . LEU D 2 109 ? 31.00305  19.62229  -24.24377 1.000 56.23993  ? 441 LEU D CD2 1 
ATOM   3031 N N   . ASP D 2 110 ? 28.81964  19.70213  -19.22834 1.000 39.26437  ? 442 ASP D N   1 
ATOM   3032 C CA  . ASP D 2 110 ? 28.75012  20.39163  -17.95062 1.000 40.81119  ? 442 ASP D CA  1 
ATOM   3033 C C   . ASP D 2 110 ? 28.45649  19.48514  -16.76285 1.000 40.57022  ? 442 ASP D C   1 
ATOM   3034 O O   . ASP D 2 110 ? 28.60890  19.93233  -15.62255 1.000 45.95849  ? 442 ASP D O   1 
ATOM   3035 C CB  . ASP D 2 110 ? 27.69897  21.51042  -18.01550 1.000 36.52727  ? 442 ASP D CB  1 
ATOM   3036 C CG  . ASP D 2 110 ? 28.09179  22.62148  -18.97482 1.000 40.35597  ? 442 ASP D CG  1 
ATOM   3037 O OD1 . ASP D 2 110 ? 29.27389  23.02400  -18.97073 1.000 39.88581  ? 442 ASP D OD1 1 
ATOM   3038 O OD2 . ASP D 2 110 ? 27.22383  23.08722  -19.74144 1.000 36.76864  ? 442 ASP D OD2 1 
ATOM   3039 N N   . SER D 2 111 ? 28.04512  18.24046  -16.98385 1.000 41.45904  ? 443 SER D N   1 
ATOM   3040 C CA  . SER D 2 111 ? 27.87269  17.28830  -15.89376 1.000 42.09725  ? 443 SER D CA  1 
ATOM   3041 C C   . SER D 2 111 ? 29.18315  16.56209  -15.63065 1.000 45.32884  ? 443 SER D C   1 
ATOM   3042 O O   . SER D 2 111 ? 29.94847  16.28134  -16.55661 1.000 41.35409  ? 443 SER D O   1 
ATOM   3043 C CB  . SER D 2 111 ? 26.77836  16.26857  -16.21507 1.000 41.04049  ? 443 SER D CB  1 
ATOM   3044 O OG  . SER D 2 111 ? 25.50371  16.87791  -16.25633 1.000 44.93739  ? 443 SER D OG  1 
ATOM   3045 N N   . LYS D 2 112 ? 29.43356  16.25662  -14.36314 1.000 41.65865  ? 444 LYS D N   1 
ATOM   3046 C CA  . LYS D 2 112 ? 30.62624  15.53116  -13.95387 1.000 51.42674  ? 444 LYS D CA  1 
ATOM   3047 C C   . LYS D 2 112 ? 30.23242  14.41228  -13.00235 1.000 53.53418  ? 444 LYS D C   1 
ATOM   3048 O O   . LYS D 2 112 ? 29.36002  14.59213  -12.14522 1.000 49.90916  ? 444 LYS D O   1 
ATOM   3049 C CB  . LYS D 2 112 ? 31.64983  16.45834  -13.27179 1.000 48.54735  ? 444 LYS D CB  1 
ATOM   3050 C CG  . LYS D 2 112 ? 32.19512  17.56536  -14.16994 1.000 58.47524  ? 444 LYS D CG  1 
ATOM   3051 C CD  . LYS D 2 112 ? 33.02507  17.00141  -15.31705 1.000 67.84317  ? 444 LYS D CD  1 
ATOM   3052 C CE  . LYS D 2 112 ? 33.61001  18.11360  -16.18545 1.000 69.91840  ? 444 LYS D CE  1 
ATOM   3053 N NZ  . LYS D 2 112 ? 32.55090  18.94920  -16.82881 1.000 57.37755  ? 444 LYS D NZ  1 
ATOM   3054 N N   . VAL D 2 113 ? 30.86363  13.24975  -13.17457 1.000 53.39877  ? 445 VAL D N   1 
ATOM   3055 C CA  . VAL D 2 113 ? 30.73083  12.17616  -12.19652 1.000 49.68543  ? 445 VAL D CA  1 
ATOM   3056 C C   . VAL D 2 113 ? 31.17658  12.70470  -10.84321 1.000 52.28003  ? 445 VAL D C   1 
ATOM   3057 O O   . VAL D 2 113 ? 32.31520  13.16079  -10.68174 1.000 55.75123  ? 445 VAL D O   1 
ATOM   3058 C CB  . VAL D 2 113 ? 31.54853  10.95259  -12.61661 1.000 52.93810  ? 445 VAL D CB  1 
ATOM   3059 C CG1 . VAL D 2 113 ? 31.41353  9.84653   -11.57974 1.000 49.06290  ? 445 VAL D CG1 1 
ATOM   3060 C CG2 . VAL D 2 113 ? 31.10867  10.46732  -13.99107 1.000 51.81992  ? 445 VAL D CG2 1 
ATOM   3061 N N   . GLY D 2 114 ? 30.27845  12.65715  -9.86527  1.000 49.40522  ? 446 GLY D N   1 
ATOM   3062 C CA  . GLY D 2 114 ? 30.51205  13.28380  -8.58291  1.000 48.37771  ? 446 GLY D CA  1 
ATOM   3063 C C   . GLY D 2 114 ? 29.93570  14.67614  -8.45950  1.000 52.36139  ? 446 GLY D C   1 
ATOM   3064 O O   . GLY D 2 114 ? 29.92607  15.22982  -7.35250  1.000 54.96741  ? 446 GLY D O   1 
ATOM   3065 N N   . GLY D 2 115 ? 29.45951  15.25777  -9.55943  1.000 49.27252  ? 447 GLY D N   1 
ATOM   3066 C CA  . GLY D 2 115 ? 28.77733  16.53344  -9.49579  1.000 44.41629  ? 447 GLY D CA  1 
ATOM   3067 C C   . GLY D 2 115 ? 29.62453  17.71994  -9.90192  1.000 45.14800  ? 447 GLY D C   1 
ATOM   3068 O O   . GLY D 2 115 ? 30.77661  17.85448  -9.47928  1.000 46.75419  ? 447 GLY D O   1 
ATOM   3069 N N   . ASN D 2 116 ? 29.05644  18.59197  -10.72600 1.000 40.87231  ? 448 ASN D N   1 
ATOM   3070 C CA  . ASN D 2 116 ? 29.69642  19.84574  -11.11095 1.000 41.42679  ? 448 ASN D CA  1 
ATOM   3071 C C   . ASN D 2 116 ? 29.13453  20.93777  -10.20989 1.000 44.16627  ? 448 ASN D C   1 
ATOM   3072 O O   . ASN D 2 116 ? 28.03512  21.44905  -10.44297 1.000 38.61759  ? 448 ASN D O   1 
ATOM   3073 C CB  . ASN D 2 116 ? 29.45643  20.15570  -12.58454 1.000 37.60516  ? 448 ASN D CB  1 
ATOM   3074 C CG  . ASN D 2 116 ? 30.25464  21.34974  -13.06753 1.000 42.34457  ? 448 ASN D CG  1 
ATOM   3075 O OD1 . ASN D 2 116 ? 30.72865  22.16140  -12.27036 1.000 44.33001  ? 448 ASN D OD1 1 
ATOM   3076 N ND2 . ASN D 2 116 ? 30.40341  21.46721  -14.38344 1.000 39.27625  ? 448 ASN D ND2 1 
ATOM   3077 N N   . TYR D 2 117 ? 29.89790  21.29941  -9.18383  1.000 43.17182  ? 449 TYR D N   1 
ATOM   3078 C CA  . TYR D 2 117 ? 29.49896  22.33787  -8.24890  1.000 38.49882  ? 449 TYR D CA  1 
ATOM   3079 C C   . TYR D 2 117 ? 30.06986  23.70575  -8.60831  1.000 40.34432  ? 449 TYR D C   1 
ATOM   3080 O O   . TYR D 2 117 ? 29.89406  24.65687  -7.84099  1.000 39.49387  ? 449 TYR D O   1 
ATOM   3081 C CB  . TYR D 2 117 ? 29.90707  21.93576  -6.82497  1.000 45.31979  ? 449 TYR D CB  1 
ATOM   3082 C CG  . TYR D 2 117 ? 29.12110  20.74586  -6.31168  1.000 38.90369  ? 449 TYR D CG  1 
ATOM   3083 C CD1 . TYR D 2 117 ? 29.54392  19.44633  -6.55252  1.000 38.95500  ? 449 TYR D CD1 1 
ATOM   3084 C CD2 . TYR D 2 117 ? 27.93868  20.92718  -5.61000  1.000 40.91562  ? 449 TYR D CD2 1 
ATOM   3085 C CE1 . TYR D 2 117 ? 28.81310  18.35916  -6.09459  1.000 39.00779  ? 449 TYR D CE1 1 
ATOM   3086 C CE2 . TYR D 2 117 ? 27.20290  19.85206  -5.14874  1.000 39.35307  ? 449 TYR D CE2 1 
ATOM   3087 C CZ  . TYR D 2 117 ? 27.64138  18.57358  -5.39482  1.000 39.54782  ? 449 TYR D CZ  1 
ATOM   3088 O OH  . TYR D 2 117 ? 26.90414  17.51185  -4.93389  1.000 46.55864  ? 449 TYR D OH  1 
ATOM   3089 N N   . ASN D 2 118 ? 30.73939  23.83025  -9.75730  1.000 39.96679  ? 450 ASN D N   1 
ATOM   3090 C CA  . ASN D 2 118 ? 31.22594  25.13956  -10.18309 1.000 41.40705  ? 450 ASN D CA  1 
ATOM   3091 C C   . ASN D 2 118 ? 30.07588  26.04656  -10.60175 1.000 41.86913  ? 450 ASN D C   1 
ATOM   3092 O O   . ASN D 2 118 ? 30.10427  27.25400  -10.33836 1.000 41.23184  ? 450 ASN D O   1 
ATOM   3093 C CB  . ASN D 2 118 ? 32.22050  24.99360  -11.33477 1.000 44.29983  ? 450 ASN D CB  1 
ATOM   3094 C CG  . ASN D 2 118 ? 33.43661  24.17439  -10.96358 1.000 48.21513  ? 450 ASN D CG  1 
ATOM   3095 O OD1 . ASN D 2 118 ? 33.83549  24.11834  -9.80183  1.000 52.07623  ? 450 ASN D OD1 1 
ATOM   3096 N ND2 . ASN D 2 118 ? 34.03734  23.53285  -11.95820 1.000 53.44048  ? 450 ASN D ND2 1 
ATOM   3097 N N   . TYR D 2 119 ? 29.06724  25.49072  -11.27014 1.000 41.18091  ? 451 TYR D N   1 
ATOM   3098 C CA  . TYR D 2 119 ? 27.92367  26.28803  -11.69295 1.000 40.82056  ? 451 TYR D CA  1 
ATOM   3099 C C   . TYR D 2 119 ? 27.02793  26.58060  -10.49981 1.000 34.63077  ? 451 TYR D C   1 
ATOM   3100 O O   . TYR D 2 119 ? 26.66676  25.67365  -9.74435  1.000 36.99621  ? 451 TYR D O   1 
ATOM   3101 C CB  . TYR D 2 119 ? 27.12407  25.56392  -12.77276 1.000 32.15628  ? 451 TYR D CB  1 
ATOM   3102 C CG  . TYR D 2 119 ? 27.79496  25.49241  -14.12333 1.000 35.63159  ? 451 TYR D CG  1 
ATOM   3103 C CD1 . TYR D 2 119 ? 27.98781  26.63573  -14.89304 1.000 38.15851  ? 451 TYR D CD1 1 
ATOM   3104 C CD2 . TYR D 2 119 ? 28.20353  24.27560  -14.64481 1.000 38.15199  ? 451 TYR D CD2 1 
ATOM   3105 C CE1 . TYR D 2 119 ? 28.59536  26.56509  -16.13899 1.000 37.10482  ? 451 TYR D CE1 1 
ATOM   3106 C CE2 . TYR D 2 119 ? 28.80688  24.19373  -15.88310 1.000 42.26606  ? 451 TYR D CE2 1 
ATOM   3107 C CZ  . TYR D 2 119 ? 29.00042  25.33963  -16.62596 1.000 39.99800  ? 451 TYR D CZ  1 
ATOM   3108 O OH  . TYR D 2 119 ? 29.59959  25.25089  -17.85865 1.000 45.22498  ? 451 TYR D OH  1 
ATOM   3109 N N   . ARG D 2 120 ? 26.64985  27.84448  -10.34029 1.000 37.52268  ? 452 ARG D N   1 
ATOM   3110 C CA  . ARG D 2 120 ? 25.85522  28.24774  -9.19403  1.000 41.65267  ? 452 ARG D CA  1 
ATOM   3111 C C   . ARG D 2 120 ? 24.70202  29.13000  -9.64418  1.000 38.66530  ? 452 ARG D C   1 
ATOM   3112 O O   . ARG D 2 120 ? 24.70285  29.68157  -10.74703 1.000 37.90578  ? 452 ARG D O   1 
ATOM   3113 C CB  . ARG D 2 120 ? 26.71254  28.97006  -8.14055  1.000 37.95744  ? 452 ARG D CB  1 
ATOM   3114 C CG  . ARG D 2 120 ? 27.74184  28.05951  -7.47702  1.000 42.77103  ? 452 ARG D CG  1 
ATOM   3115 C CD  . ARG D 2 120 ? 28.44744  28.73531  -6.31257  1.000 41.10745  ? 452 ARG D CD  1 
ATOM   3116 N NE  . ARG D 2 120 ? 29.23580  29.88227  -6.74719  1.000 51.02734  ? 452 ARG D NE  1 
ATOM   3117 C CZ  . ARG D 2 120 ? 29.94887  30.65342  -5.93721  1.000 58.84141  ? 452 ARG D CZ  1 
ATOM   3118 N NH1 . ARG D 2 120 ? 30.00444  30.42092  -4.63506  1.000 45.48828  ? 452 ARG D NH1 1 
ATOM   3119 N NH2 . ARG D 2 120 ? 30.62145  31.68373  -6.44753  1.000 50.61102  ? 452 ARG D NH2 1 
ATOM   3120 N N   . TYR D 2 121 ? 23.70525  29.23081  -8.76561  1.000 38.03404  ? 453 TYR D N   1 
ATOM   3121 C CA  . TYR D 2 121 ? 22.54935  30.09504  -8.93611  1.000 31.82762  ? 453 TYR D CA  1 
ATOM   3122 C C   . TYR D 2 121 ? 22.24454  30.73132  -7.58955  1.000 34.18456  ? 453 TYR D C   1 
ATOM   3123 O O   . TYR D 2 121 ? 22.57531  30.17782  -6.53996  1.000 36.61042  ? 453 TYR D O   1 
ATOM   3124 C CB  . TYR D 2 121 ? 21.32772  29.31390  -9.44742  1.000 37.97171  ? 453 TYR D CB  1 
ATOM   3125 C CG  . TYR D 2 121 ? 20.84615  28.25418  -8.48088  1.000 34.50335  ? 453 TYR D CG  1 
ATOM   3126 C CD1 . TYR D 2 121 ? 21.41022  26.98371  -8.47266  1.000 35.19602  ? 453 TYR D CD1 1 
ATOM   3127 C CD2 . TYR D 2 121 ? 19.83598  28.52845  -7.56831  1.000 33.33603  ? 453 TYR D CD2 1 
ATOM   3128 C CE1 . TYR D 2 121 ? 20.97838  26.01673  -7.58388  1.000 33.52377  ? 453 TYR D CE1 1 
ATOM   3129 C CE2 . TYR D 2 121 ? 19.39796  27.57046  -6.67510  1.000 34.65832  ? 453 TYR D CE2 1 
ATOM   3130 C CZ  . TYR D 2 121 ? 19.97330  26.31617  -6.68697  1.000 38.33623  ? 453 TYR D CZ  1 
ATOM   3131 O OH  . TYR D 2 121 ? 19.54357  25.35678  -5.80074  1.000 35.61606  ? 453 TYR D OH  1 
ATOM   3132 N N   . ARG D 2 122 ? 21.60776  31.89960  -7.62099  1.000 38.57035  ? 454 ARG D N   1 
ATOM   3133 C CA  . ARG D 2 122 ? 21.23169  32.59675  -6.39786  1.000 38.77886  ? 454 ARG D CA  1 
ATOM   3134 C C   . ARG D 2 122 ? 19.86615  32.10792  -5.93506  1.000 37.73559  ? 454 ARG D C   1 
ATOM   3135 O O   . ARG D 2 122 ? 18.91327  32.07477  -6.72078  1.000 39.33812  ? 454 ARG D O   1 
ATOM   3136 C CB  . ARG D 2 122 ? 21.21066  34.11167  -6.61411  1.000 33.55429  ? 454 ARG D CB  1 
ATOM   3137 C CG  . ARG D 2 122 ? 20.90290  34.91993  -5.35224  1.000 34.81529  ? 454 ARG D CG  1 
ATOM   3138 C CD  . ARG D 2 122 ? 20.98657  36.42078  -5.62244  1.000 43.51816  ? 454 ARG D CD  1 
ATOM   3139 N NE  . ARG D 2 122 ? 22.29805  36.79484  -6.13944  1.000 42.52475  ? 454 ARG D NE  1 
ATOM   3140 C CZ  . ARG D 2 122 ? 23.36033  37.03586  -5.38454  1.000 48.17998  ? 454 ARG D CZ  1 
ATOM   3141 N NH1 . ARG D 2 122 ? 23.28762  37.01331  -4.06101  1.000 41.29620  ? 454 ARG D NH1 1 
ATOM   3142 N NH2 . ARG D 2 122 ? 24.52617  37.29254  -5.97193  1.000 42.09796  ? 454 ARG D NH2 1 
ATOM   3143 N N   . LEU D 2 123 ? 19.77600  31.72991  -4.66029  1.000 39.49089  ? 455 LEU D N   1 
ATOM   3144 C CA  . LEU D 2 123 ? 18.53686  31.23204  -4.07644  1.000 35.89445  ? 455 LEU D CA  1 
ATOM   3145 C C   . LEU D 2 123 ? 17.84712  32.22947  -3.15761  1.000 44.65050  ? 455 LEU D C   1 
ATOM   3146 O O   . LEU D 2 123 ? 16.62823  32.15063  -2.99008  1.000 40.52318  ? 455 LEU D O   1 
ATOM   3147 C CB  . LEU D 2 123 ? 18.80157  29.93745  -3.29354  1.000 35.93799  ? 455 LEU D CB  1 
ATOM   3148 C CG  . LEU D 2 123 ? 17.60274  29.22545  -2.65808  1.000 39.62465  ? 455 LEU D CG  1 
ATOM   3149 C CD1 . LEU D 2 123 ? 16.55434  28.89415  -3.71675  1.000 40.54330  ? 455 LEU D CD1 1 
ATOM   3150 C CD2 . LEU D 2 123 ? 18.04324  27.97031  -1.92250  1.000 34.59355  ? 455 LEU D CD2 1 
ATOM   3151 N N   . PHE D 2 124 ? 18.58763  33.16593  -2.56662  1.000 41.34289  ? 456 PHE D N   1 
ATOM   3152 C CA  . PHE D 2 124 ? 18.04554  34.11773  -1.60550  1.000 41.07988  ? 456 PHE D CA  1 
ATOM   3153 C C   . PHE D 2 124 ? 18.29326  35.53739  -2.09718  1.000 44.50762  ? 456 PHE D C   1 
ATOM   3154 O O   . PHE D 2 124 ? 19.41417  35.87063  -2.49484  1.000 44.19353  ? 456 PHE D O   1 
ATOM   3155 C CB  . PHE D 2 124 ? 18.68273  33.92865  -0.22388  1.000 38.14477  ? 456 PHE D CB  1 
ATOM   3156 C CG  . PHE D 2 124 ? 18.59806  32.52352  0.30858   1.000 41.84083  ? 456 PHE D CG  1 
ATOM   3157 C CD1 . PHE D 2 124 ? 19.58146  31.59114  0.00841   1.000 44.60898  ? 456 PHE D CD1 1 
ATOM   3158 C CD2 . PHE D 2 124 ? 17.54854  32.14058  1.13124   1.000 44.80445  ? 456 PHE D CD2 1 
ATOM   3159 C CE1 . PHE D 2 124 ? 19.51013  30.29745  0.50927   1.000 45.32088  ? 456 PHE D CE1 1 
ATOM   3160 C CE2 . PHE D 2 124 ? 17.47107  30.84856  1.63717   1.000 37.30804  ? 456 PHE D CE2 1 
ATOM   3161 C CZ  . PHE D 2 124 ? 18.45374  29.92813  1.32666   1.000 40.26678  ? 456 PHE D CZ  1 
ATOM   3162 N N   . ARG D 2 125 ? 17.25475  36.37209  -2.05968  1.000 43.79699  ? 457 ARG D N   1 
ATOM   3163 C CA  . ARG D 2 125 ? 17.39465  37.77899  -2.41184  1.000 44.96297  ? 457 ARG D CA  1 
ATOM   3164 C C   . ARG D 2 125 ? 16.18442  38.53896  -1.88719  1.000 47.48499  ? 457 ARG D C   1 
ATOM   3165 O O   . ARG D 2 125 ? 15.05484  38.05012  -1.97452  1.000 48.23409  ? 457 ARG D O   1 
ATOM   3166 C CB  . ARG D 2 125 ? 17.53489  37.97289  -3.92769  1.000 41.21154  ? 457 ARG D CB  1 
ATOM   3167 C CG  . ARG D 2 125 ? 18.21290  39.27593  -4.31976  1.000 42.75341  ? 457 ARG D CG  1 
ATOM   3168 C CD  . ARG D 2 125 ? 18.42752  39.37814  -5.82642  1.000 45.55618  ? 457 ARG D CD  1 
ATOM   3169 N NE  . ARG D 2 125 ? 19.32221  40.48156  -6.15532  1.000 46.32106  ? 457 ARG D NE  1 
ATOM   3170 C CZ  . ARG D 2 125 ? 18.92668  41.72079  -6.41074  1.000 48.59469  ? 457 ARG D CZ  1 
ATOM   3171 N NH1 . ARG D 2 125 ? 17.64518  42.04765  -6.43432  1.000 47.08376  ? 457 ARG D NH1 1 
ATOM   3172 N NH2 . ARG D 2 125 ? 19.84028  42.65468  -6.65210  1.000 48.64263  ? 457 ARG D NH2 1 
ATOM   3173 N N   . LYS D 2 126 ? 16.43010  39.73758  -1.34843  1.000 50.08885  ? 458 LYS D N   1 
ATOM   3174 C CA  . LYS D 2 126 ? 15.34888  40.51456  -0.74671  1.000 49.09090  ? 458 LYS D CA  1 
ATOM   3175 C C   . LYS D 2 126 ? 14.35440  40.99528  -1.79616  1.000 53.89993  ? 458 LYS D C   1 
ATOM   3176 O O   . LYS D 2 126 ? 13.13957  40.95905  -1.56901  1.000 66.52040  ? 458 LYS D O   1 
ATOM   3177 C CB  . LYS D 2 126 ? 15.91687  41.69959  0.03634   1.000 48.64136  ? 458 LYS D CB  1 
ATOM   3178 C CG  . LYS D 2 126 ? 16.47938  41.34312  1.41493   1.000 60.87106  ? 458 LYS D CG  1 
ATOM   3179 C CD  . LYS D 2 126 ? 15.41581  40.69308  2.30195   1.000 63.17598  ? 458 LYS D CD  1 
ATOM   3180 C CE  . LYS D 2 126 ? 15.82473  40.66933  3.77730   1.000 60.00087  ? 458 LYS D CE  1 
ATOM   3181 N NZ  . LYS D 2 126 ? 17.13547  39.99339  4.02507   1.000 59.39030  ? 458 LYS D NZ  1 
ATOM   3182 N N   . SER D 2 127 ? 14.84128  41.44323  -2.94865  1.000 44.85613  ? 459 SER D N   1 
ATOM   3183 C CA  . SER D 2 127 ? 13.97889  41.94450  -4.00627  1.000 48.37460  ? 459 SER D CA  1 
ATOM   3184 C C   . SER D 2 127 ? 14.29273  41.23284  -5.31560  1.000 45.10475  ? 459 SER D C   1 
ATOM   3185 O O   . SER D 2 127 ? 15.35231  40.62569  -5.48164  1.000 45.67798  ? 459 SER D O   1 
ATOM   3186 C CB  . SER D 2 127 ? 14.13750  43.45851  -4.18523  1.000 48.51052  ? 459 SER D CB  1 
ATOM   3187 O OG  . SER D 2 127 ? 15.49508  43.79156  -4.42526  1.000 58.21335  ? 459 SER D OG  1 
ATOM   3188 N N   . ASN D 2 128 ? 13.34807  41.31237  -6.24664  1.000 43.69090  ? 460 ASN D N   1 
ATOM   3189 C CA  . ASN D 2 128 ? 13.55536  40.74828  -7.56845  1.000 48.10867  ? 460 ASN D CA  1 
ATOM   3190 C C   . ASN D 2 128 ? 14.50274  41.62627  -8.38293  1.000 50.12611  ? 460 ASN D C   1 
ATOM   3191 O O   . ASN D 2 128 ? 14.70360  42.80992  -8.09762  1.000 54.47751  ? 460 ASN D O   1 
ATOM   3192 C CB  . ASN D 2 128 ? 12.22469  40.59457  -8.30407  1.000 42.46595  ? 460 ASN D CB  1 
ATOM   3193 C CG  . ASN D 2 128 ? 11.32057  39.56103  -7.66333  1.000 47.96879  ? 460 ASN D CG  1 
ATOM   3194 O OD1 . ASN D 2 128 ? 11.76151  38.75961  -6.84066  1.000 44.49432  ? 460 ASN D OD1 1 
ATOM   3195 N ND2 . ASN D 2 128 ? 10.05014  39.56333  -8.05114  1.000 48.97214  ? 460 ASN D ND2 1 
ATOM   3196 N N   . LEU D 2 129 ? 15.08835  41.02759  -9.41366  1.000 52.56776  ? 461 LEU D N   1 
ATOM   3197 C CA  . LEU D 2 129 ? 15.97540  41.76060  -10.30042 1.000 47.47160  ? 461 LEU D CA  1 
ATOM   3198 C C   . LEU D 2 129 ? 15.17684  42.58063  -11.30312 1.000 44.82887  ? 461 LEU D C   1 
ATOM   3199 O O   . LEU D 2 129 ? 14.08430  42.19625  -11.72862 1.000 42.96073  ? 461 LEU D O   1 
ATOM   3200 C CB  . LEU D 2 129 ? 16.90364  40.80735  -11.05148 1.000 44.19748  ? 461 LEU D CB  1 
ATOM   3201 C CG  . LEU D 2 129 ? 18.01368  40.09156  -10.28264 1.000 46.91172  ? 461 LEU D CG  1 
ATOM   3202 C CD1 . LEU D 2 129 ? 18.71176  39.12611  -11.21195 1.000 39.78885  ? 461 LEU D CD1 1 
ATOM   3203 C CD2 . LEU D 2 129 ? 19.00968  41.08273  -9.71326  1.000 45.99308  ? 461 LEU D CD2 1 
ATOM   3204 N N   . LYS D 2 130 ? 15.73296  43.72404  -11.67034 1.000 47.49468  ? 462 LYS D N   1 
ATOM   3205 C CA  . LYS D 2 130 ? 15.23643  44.47998  -12.80477 1.000 50.11108  ? 462 LYS D CA  1 
ATOM   3206 C C   . LYS D 2 130 ? 15.69585  43.80973  -14.09549 1.000 46.60479  ? 462 LYS D C   1 
ATOM   3207 O O   . LYS D 2 130 ? 16.65693  43.03571  -14.09039 1.000 44.00044  ? 462 LYS D O   1 
ATOM   3208 C CB  . LYS D 2 130 ? 15.73852  45.91959  -12.73326 1.000 51.65669  ? 462 LYS D CB  1 
ATOM   3209 C CG  . LYS D 2 130 ? 15.26721  46.66980  -11.49193 1.000 55.46552  ? 462 LYS D CG  1 
ATOM   3210 C CD  . LYS D 2 130 ? 15.69923  48.12505  -11.52869 1.000 71.55861  ? 462 LYS D CD  1 
ATOM   3211 C CE  . LYS D 2 130 ? 15.18712  48.87927  -10.31321 1.000 93.21857  ? 462 LYS D CE  1 
ATOM   3212 N NZ  . LYS D 2 130 ? 15.62624  50.30232  -10.32129 1.000 100.46599 ? 462 LYS D NZ  1 
ATOM   3213 N N   . PRO D 2 131 ? 15.01464  44.06520  -15.21151 1.000 42.74486  ? 463 PRO D N   1 
ATOM   3214 C CA  . PRO D 2 131 ? 15.42462  43.43498  -16.47410 1.000 44.05758  ? 463 PRO D CA  1 
ATOM   3215 C C   . PRO D 2 131 ? 16.89217  43.69895  -16.77955 1.000 47.69321  ? 463 PRO D C   1 
ATOM   3216 O O   . PRO D 2 131 ? 17.37360  44.82728  -16.66472 1.000 45.54996  ? 463 PRO D O   1 
ATOM   3217 C CB  . PRO D 2 131 ? 14.49942  44.08309  -17.50778 1.000 44.40538  ? 463 PRO D CB  1 
ATOM   3218 C CG  . PRO D 2 131 ? 13.26601  44.40834  -16.72635 1.000 46.86427  ? 463 PRO D CG  1 
ATOM   3219 C CD  . PRO D 2 131 ? 13.75684  44.82074  -15.35794 1.000 43.56435  ? 463 PRO D CD  1 
ATOM   3220 N N   . PHE D 2 132 ? 17.60709  42.62468  -17.12861 1.000 42.70884  ? 464 PHE D N   1 
ATOM   3221 C CA  . PHE D 2 132 ? 19.02618  42.66036  -17.49783 1.000 42.47646  ? 464 PHE D CA  1 
ATOM   3222 C C   . PHE D 2 132 ? 19.92401  43.12100  -16.35270 1.000 39.27259  ? 464 PHE D C   1 
ATOM   3223 O O   . PHE D 2 132 ? 21.05085  43.56430  -16.57936 1.000 44.42824  ? 464 PHE D O   1 
ATOM   3224 C CB  . PHE D 2 132 ? 19.26397  43.52319  -18.73897 1.000 44.20227  ? 464 PHE D CB  1 
ATOM   3225 C CG  . PHE D 2 132 ? 18.60966  42.98670  -19.97192 1.000 43.60253  ? 464 PHE D CG  1 
ATOM   3226 C CD1 . PHE D 2 132 ? 18.95056  41.73708  -20.45789 1.000 39.16335  ? 464 PHE D CD1 1 
ATOM   3227 C CD2 . PHE D 2 132 ? 17.65295  43.72790  -20.64238 1.000 40.29159  ? 464 PHE D CD2 1 
ATOM   3228 C CE1 . PHE D 2 132 ? 18.35137  41.23601  -21.58816 1.000 42.09706  ? 464 PHE D CE1 1 
ATOM   3229 C CE2 . PHE D 2 132 ? 17.04947  43.23349  -21.77706 1.000 40.83751  ? 464 PHE D CE2 1 
ATOM   3230 C CZ  . PHE D 2 132 ? 17.39829  41.98354  -22.25127 1.000 46.59500  ? 464 PHE D CZ  1 
ATOM   3231 N N   . GLU D 2 133 ? 19.45217  43.00666  -15.11706 1.000 42.57863  ? 465 GLU D N   1 
ATOM   3232 C CA  . GLU D 2 133 ? 20.28120  43.29362  -13.95662 1.000 43.35321  ? 465 GLU D CA  1 
ATOM   3233 C C   . GLU D 2 133 ? 21.09505  42.05832  -13.57595 1.000 50.62781  ? 465 GLU D C   1 
ATOM   3234 O O   . GLU D 2 133 ? 20.67025  40.91948  -13.79651 1.000 41.73150  ? 465 GLU D O   1 
ATOM   3235 C CB  . GLU D 2 133 ? 19.41522  43.75063  -12.77999 1.000 41.63043  ? 465 GLU D CB  1 
ATOM   3236 C CG  . GLU D 2 133 ? 20.19458  44.23800  -11.56795 1.000 52.04674  ? 465 GLU D CG  1 
ATOM   3237 C CD  . GLU D 2 133 ? 19.29479  44.64810  -10.40875 1.000 51.23505  ? 465 GLU D CD  1 
ATOM   3238 O OE1 . GLU D 2 133 ? 18.05498  44.64711  -10.57665 1.000 49.76796  ? 465 GLU D OE1 1 
ATOM   3239 O OE2 . GLU D 2 133 ? 19.82990  44.97060  -9.32560  1.000 54.04408  ? 465 GLU D OE2 1 
ATOM   3240 N N   . ARG D 2 134 ? 22.28449  42.29471  -13.01828 1.000 44.92837  ? 466 ARG D N   1 
ATOM   3241 C CA  . ARG D 2 134 ? 23.16982  41.23281  -12.55597 1.000 47.14428  ? 466 ARG D CA  1 
ATOM   3242 C C   . ARG D 2 134 ? 23.56047  41.48961  -11.10659 1.000 47.40064  ? 466 ARG D C   1 
ATOM   3243 O O   . ARG D 2 134 ? 23.83872  42.62890  -10.72361 1.000 49.46987  ? 466 ARG D O   1 
ATOM   3244 C CB  . ARG D 2 134 ? 24.43622  41.12810  -13.42795 1.000 45.72080  ? 466 ARG D CB  1 
ATOM   3245 C CG  . ARG D 2 134 ? 25.34328  39.94704  -13.07362 1.000 46.01030  ? 466 ARG D CG  1 
ATOM   3246 C CD  . ARG D 2 134 ? 26.74819  40.06228  -13.67978 1.000 44.82239  ? 466 ARG D CD  1 
ATOM   3247 N NE  . ARG D 2 134 ? 26.75599  39.90342  -15.12801 1.000 48.67718  ? 466 ARG D NE  1 
ATOM   3248 C CZ  . ARG D 2 134 ? 26.80791  40.90782  -15.99283 1.000 57.39883  ? 466 ARG D CZ  1 
ATOM   3249 N NH1 . ARG D 2 134 ? 26.87720  42.16520  -15.58721 1.000 60.39009  ? 466 ARG D NH1 1 
ATOM   3250 N NH2 . ARG D 2 134 ? 26.79191  40.64367  -17.29795 1.000 52.47185  ? 466 ARG D NH2 1 
ATOM   3251 N N   . ASP D 2 135 ? 23.57828  40.42719  -10.30190 1.000 46.94059  ? 467 ASP D N   1 
ATOM   3252 C CA  . ASP D 2 135 ? 23.94660  40.50571  -8.89022  1.000 39.73613  ? 467 ASP D CA  1 
ATOM   3253 C C   . ASP D 2 135 ? 24.94041  39.39173  -8.59103  1.000 46.79055  ? 467 ASP D C   1 
ATOM   3254 O O   . ASP D 2 135 ? 24.56339  38.21611  -8.53800  1.000 43.62352  ? 467 ASP D O   1 
ATOM   3255 C CB  . ASP D 2 135 ? 22.71291  40.39943  -7.98926  1.000 40.79083  ? 467 ASP D CB  1 
ATOM   3256 C CG  . ASP D 2 135 ? 23.05290  40.48441  -6.50041  1.000 53.90433  ? 467 ASP D CG  1 
ATOM   3257 O OD1 . ASP D 2 135 ? 24.24747  40.62364  -6.14476  1.000 49.54343  ? 467 ASP D OD1 1 
ATOM   3258 O OD2 . ASP D 2 135 ? 22.11120  40.41171  -5.67883  1.000 47.47179  ? 467 ASP D OD2 1 
ATOM   3259 N N   . ILE D 2 136 ? 26.20160  39.76326  -8.37521  1.000 47.00000  ? 468 ILE D N   1 
ATOM   3260 C CA  . ILE D 2 136 ? 27.25349  38.81974  -8.01741  1.000 46.51195  ? 468 ILE D CA  1 
ATOM   3261 C C   . ILE D 2 136 ? 27.67739  38.96601  -6.56067  1.000 45.53785  ? 468 ILE D C   1 
ATOM   3262 O O   . ILE D 2 136 ? 28.71656  38.42487  -6.16549  1.000 47.35594  ? 468 ILE D O   1 
ATOM   3263 C CB  . ILE D 2 136 ? 28.46857  38.95495  -8.94942  1.000 44.11901  ? 468 ILE D CB  1 
ATOM   3264 C CG1 . ILE D 2 136 ? 29.11740  40.33199  -8.78015  1.000 48.03090  ? 468 ILE D CG1 1 
ATOM   3265 C CG2 . ILE D 2 136 ? 28.06512  38.71474  -10.39742 1.000 40.76861  ? 468 ILE D CG2 1 
ATOM   3266 C CD1 . ILE D 2 136 ? 30.38101  40.51759  -9.59664  1.000 42.00085  ? 468 ILE D CD1 1 
ATOM   3267 N N   . SER D 2 137 ? 26.90424  39.68501  -5.75004  1.000 46.05418  ? 469 SER D N   1 
ATOM   3268 C CA  . SER D 2 137 ? 27.23951  39.83072  -4.34073  1.000 46.25685  ? 469 SER D CA  1 
ATOM   3269 C C   . SER D 2 137 ? 27.06718  38.50346  -3.61333  1.000 51.01461  ? 469 SER D C   1 
ATOM   3270 O O   . SER D 2 137 ? 26.26435  37.65338  -4.00818  1.000 55.94098  ? 469 SER D O   1 
ATOM   3271 C CB  . SER D 2 137 ? 26.36587  40.90044  -3.68700  1.000 48.60840  ? 469 SER D CB  1 
ATOM   3272 O OG  . SER D 2 137 ? 24.99525  40.55375  -3.75113  1.000 51.24785  ? 469 SER D OG  1 
ATOM   3273 N N   . THR D 2 138 ? 27.83446  38.32717  -2.53892  1.000 54.51779  ? 470 THR D N   1 
ATOM   3274 C CA  . THR D 2 138 ? 27.81186  37.09661  -1.75654  1.000 47.74834  ? 470 THR D CA  1 
ATOM   3275 C C   . THR D 2 138 ? 27.68910  37.39526  -0.27000  1.000 56.09524  ? 470 THR D C   1 
ATOM   3276 O O   . THR D 2 138 ? 28.34153  36.76129  0.56437   1.000 57.39690  ? 470 THR D O   1 
ATOM   3277 C CB  . THR D 2 138 ? 29.05596  36.25011  -2.01797  1.000 50.56561  ? 470 THR D CB  1 
ATOM   3278 O OG1 . THR D 2 138 ? 30.22806  37.02943  -1.75290  1.000 55.99355  ? 470 THR D OG1 1 
ATOM   3279 C CG2 . THR D 2 138 ? 29.08841  35.76079  -3.45776  1.000 49.07016  ? 470 THR D CG2 1 
ATOM   3280 N N   . GLU D 2 139 ? 26.84908  38.35608  0.09589   1.000 52.11553  ? 471 GLU D N   1 
ATOM   3281 C CA  . GLU D 2 139 ? 26.64887  38.63768  1.50746   1.000 57.65094  ? 471 GLU D CA  1 
ATOM   3282 C C   . GLU D 2 139 ? 25.63821  37.66537  2.10714   1.000 60.16308  ? 471 GLU D C   1 
ATOM   3283 O O   . GLU D 2 139 ? 24.74312  37.15933  1.42300   1.000 54.52650  ? 471 GLU D O   1 
ATOM   3284 C CB  . GLU D 2 139 ? 26.18859  40.08140  1.71869   1.000 68.33111  ? 471 GLU D CB  1 
ATOM   3285 C CG  . GLU D 2 139 ? 24.77955  40.37690  1.23894   1.000 78.01386  ? 471 GLU D CG  1 
ATOM   3286 C CD  . GLU D 2 139 ? 24.36283  41.80691  1.52158   1.000 87.89191  ? 471 GLU D CD  1 
ATOM   3287 O OE1 . GLU D 2 139 ? 25.24807  42.62741  1.85236   1.000 94.42317  ? 471 GLU D OE1 1 
ATOM   3288 O OE2 . GLU D 2 139 ? 23.15264  42.10609  1.41658   1.000 90.45618  ? 471 GLU D OE2 1 
ATOM   3289 N N   . ILE D 2 140 ? 25.79720  37.40501  3.40332   1.000 54.84137  ? 472 ILE D N   1 
ATOM   3290 C CA  . ILE D 2 140 ? 24.94502  36.45219  4.10513   1.000 51.74077  ? 472 ILE D CA  1 
ATOM   3291 C C   . ILE D 2 140 ? 23.52057  36.98880  4.13828   1.000 50.83034  ? 472 ILE D C   1 
ATOM   3292 O O   . ILE D 2 140 ? 23.27551  38.11106  4.59403   1.000 59.87890  ? 472 ILE D O   1 
ATOM   3293 C CB  . ILE D 2 140 ? 25.47399  36.18864  5.52017   1.000 57.08943  ? 472 ILE D CB  1 
ATOM   3294 C CG1 . ILE D 2 140 ? 26.93087  35.72885  5.46026   1.000 58.07608  ? 472 ILE D CG1 1 
ATOM   3295 C CG2 . ILE D 2 140 ? 24.61693  35.15501  6.22624   1.000 54.08531  ? 472 ILE D CG2 1 
ATOM   3296 C CD1 . ILE D 2 140 ? 27.14511  34.50122  4.60754   1.000 55.11074  ? 472 ILE D CD1 1 
ATOM   3297 N N   . TYR D 2 141 ? 22.57486  36.18859  3.65346   1.000 51.25208  ? 473 TYR D N   1 
ATOM   3298 C CA  . TYR D 2 141 ? 21.18053  36.60395  3.61287   1.000 51.33401  ? 473 TYR D CA  1 
ATOM   3299 C C   . TYR D 2 141 ? 20.55507  36.45135  4.99315   1.000 55.42329  ? 473 TYR D C   1 
ATOM   3300 O O   . TYR D 2 141 ? 20.63950  35.38389  5.60795   1.000 54.86051  ? 473 TYR D O   1 
ATOM   3301 C CB  . TYR D 2 141 ? 20.40948  35.78201  2.58032   1.000 46.78041  ? 473 TYR D CB  1 
ATOM   3302 C CG  . TYR D 2 141 ? 18.95826  36.18452  2.42734   1.000 46.45936  ? 473 TYR D CG  1 
ATOM   3303 C CD1 . TYR D 2 141 ? 18.58420  37.18840  1.53872   1.000 48.67633  ? 473 TYR D CD1 1 
ATOM   3304 C CD2 . TYR D 2 141 ? 17.96196  35.55584  3.16390   1.000 43.57924  ? 473 TYR D CD2 1 
ATOM   3305 C CE1 . TYR D 2 141 ? 17.25703  37.55723  1.39380   1.000 50.99082  ? 473 TYR D CE1 1 
ATOM   3306 C CE2 . TYR D 2 141 ? 16.63786  35.91715  3.02903   1.000 47.94678  ? 473 TYR D CE2 1 
ATOM   3307 C CZ  . TYR D 2 141 ? 16.28909  36.91667  2.14128   1.000 53.29169  ? 473 TYR D CZ  1 
ATOM   3308 O OH  . TYR D 2 141 ? 14.96843  37.27688  2.00280   1.000 59.45089  ? 473 TYR D OH  1 
ATOM   3309 N N   . GLN D 2 142 ? 19.92332  37.51837  5.47623   1.000 56.82635  ? 474 GLN D N   1 
ATOM   3310 C CA  . GLN D 2 142 ? 19.30620  37.52715  6.80143   1.000 59.93483  ? 474 GLN D CA  1 
ATOM   3311 C C   . GLN D 2 142 ? 17.84055  37.13744  6.65424   1.000 57.22217  ? 474 GLN D C   1 
ATOM   3312 O O   . GLN D 2 142 ? 17.00399  37.95055  6.25246   1.000 56.30806  ? 474 GLN D O   1 
ATOM   3313 C CB  . GLN D 2 142 ? 19.46411  38.89436  7.45605   1.000 64.34135  ? 474 GLN D CB  1 
ATOM   3314 C CG  . GLN D 2 142 ? 18.81789  39.00287  8.82476   1.000 69.09613  ? 474 GLN D CG  1 
ATOM   3315 C CD  . GLN D 2 142 ? 19.07662  40.34285  9.48397   1.000 74.03152  ? 474 GLN D CD  1 
ATOM   3316 O OE1 . GLN D 2 142 ? 20.20420  40.84029  9.48525   1.000 67.42178  ? 474 GLN D OE1 1 
ATOM   3317 N NE2 . GLN D 2 142 ? 18.02848  40.93992  10.04214  1.000 73.18327  ? 474 GLN D NE2 1 
ATOM   3318 N N   . ALA D 2 143 ? 17.52778  35.88266  6.98044   1.000 56.87313  ? 475 ALA D N   1 
ATOM   3319 C CA  . ALA D 2 143 ? 16.16141  35.39168  6.85751   1.000 60.64670  ? 475 ALA D CA  1 
ATOM   3320 C C   . ALA D 2 143 ? 15.29198  35.75407  8.05450   1.000 65.72358  ? 475 ALA D C   1 
ATOM   3321 O O   . ALA D 2 143 ? 14.06198  35.76148  7.92887   1.000 65.32138  ? 475 ALA D O   1 
ATOM   3322 C CB  . ALA D 2 143 ? 16.16089  33.87359  6.66396   1.000 55.98259  ? 475 ALA D CB  1 
ATOM   3323 N N   . GLY D 2 144 ? 15.89390  36.05227  9.20328   1.000 64.44431  ? 476 GLY D N   1 
ATOM   3324 C CA  . GLY D 2 144 ? 15.12775  36.42322  10.37563  1.000 68.91836  ? 476 GLY D CA  1 
ATOM   3325 C C   . GLY D 2 144 ? 15.46559  37.80017  10.90813  1.000 76.06152  ? 476 GLY D C   1 
ATOM   3326 O O   . GLY D 2 144 ? 15.84792  38.69374  10.14544  1.000 70.87018  ? 476 GLY D O   1 
ATOM   3327 N N   . ASN D 2 145 ? 15.32280  37.98295  12.22311  1.000 82.42267  ? 477 ASN D N   1 
ATOM   3328 C CA  . ASN D 2 145 ? 15.62443  39.25498  12.86727  1.000 78.67577  ? 477 ASN D CA  1 
ATOM   3329 C C   . ASN D 2 145 ? 17.01006  39.30058  13.49259  1.000 72.20326  ? 477 ASN D C   1 
ATOM   3330 O O   . ASN D 2 145 ? 17.51289  40.39678  13.76121  1.000 73.44849  ? 477 ASN D O   1 
ATOM   3331 C CB  . ASN D 2 145 ? 14.58160  39.56998  13.94592  1.000 80.64179  ? 477 ASN D CB  1 
ATOM   3332 C CG  . ASN D 2 145 ? 13.19917  39.79196  13.36906  1.000 87.13944  ? 477 ASN D CG  1 
ATOM   3333 O OD1 . ASN D 2 145 ? 12.24001  39.11797  13.74562  1.000 94.60225  ? 477 ASN D OD1 1 
ATOM   3334 N ND2 . ASN D 2 145 ? 13.08968  40.74087  12.44616  1.000 89.82864  ? 477 ASN D ND2 1 
ATOM   3335 N N   . LYS D 2 146 ? 17.63073  38.15154  13.73508  1.000 71.12432  ? 478 LYS D N   1 
ATOM   3336 C CA  . LYS D 2 146 ? 18.99304  38.14692  14.24154  1.000 73.61310  ? 478 LYS D CA  1 
ATOM   3337 C C   . LYS D 2 146 ? 19.94753  38.67719  13.17399  1.000 79.14538  ? 478 LYS D C   1 
ATOM   3338 O O   . LYS D 2 146 ? 19.80786  38.34546  11.99276  1.000 75.82458  ? 478 LYS D O   1 
ATOM   3339 C CB  . LYS D 2 146 ? 19.41859  36.73869  14.65820  1.000 68.64118  ? 478 LYS D CB  1 
ATOM   3340 C CG  . LYS D 2 146 ? 19.16841  36.39868  16.11957  1.000 78.97797  ? 478 LYS D CG  1 
ATOM   3341 C CD  . LYS D 2 146 ? 17.72001  36.02686  16.38262  1.000 77.52379  ? 478 LYS D CD  1 
ATOM   3342 C CE  . LYS D 2 146 ? 17.55048  35.48746  17.79632  1.000 79.10515  ? 478 LYS D CE  1 
ATOM   3343 N NZ  . LYS D 2 146 ? 16.17108  34.98530  18.05297  1.000 88.50236  ? 478 LYS D NZ  1 
ATOM   3344 N N   . PRO D 2 147 ? 20.91458  39.50945  13.55041  1.000 84.28460  ? 479 PRO D N   1 
ATOM   3345 C CA  . PRO D 2 147 ? 21.93866  39.91936  12.58499  1.000 78.52900  ? 479 PRO D CA  1 
ATOM   3346 C C   . PRO D 2 147 ? 22.86468  38.75715  12.26599  1.000 76.82735  ? 479 PRO D C   1 
ATOM   3347 O O   . PRO D 2 147 ? 23.15783  37.91860  13.12195  1.000 73.75241  ? 479 PRO D O   1 
ATOM   3348 C CB  . PRO D 2 147 ? 22.67771  41.05012  13.30909  1.000 81.70529  ? 479 PRO D CB  1 
ATOM   3349 C CG  . PRO D 2 147 ? 22.48695  40.74224  14.75938  1.000 84.61499  ? 479 PRO D CG  1 
ATOM   3350 C CD  . PRO D 2 147 ? 21.12076  40.11926  14.87584  1.000 82.21806  ? 479 PRO D CD  1 
ATOM   3351 N N   . CYS D 2 148 ? 23.31997  38.70820  11.01600  1.000 73.52640  ? 480 CYS D N   1 
ATOM   3352 C CA  . CYS D 2 148 ? 24.18103  37.61766  10.57699  1.000 74.33158  ? 480 CYS D CA  1 
ATOM   3353 C C   . CYS D 2 148 ? 25.65798  37.90698  10.79869  1.000 70.98342  ? 480 CYS D C   1 
ATOM   3354 O O   . CYS D 2 148 ? 26.43694  36.96861  11.00862  1.000 69.78796  ? 480 CYS D O   1 
ATOM   3355 C CB  . CYS D 2 148 ? 23.93299  37.31007  9.09622   1.000 64.02046  ? 480 CYS D CB  1 
ATOM   3356 S SG  . CYS D 2 148 ? 22.24377  36.76529  8.74408   1.000 77.61646  ? 480 CYS D SG  1 
ATOM   3357 N N   . ASN D 2 149 ? 26.05581  39.18178  10.75194  1.000 71.75462  ? 481 ASN D N   1 
ATOM   3358 C CA  . ASN D 2 149 ? 27.43988  39.59515  10.99546  1.000 73.29511  ? 481 ASN D CA  1 
ATOM   3359 C C   . ASN D 2 149 ? 28.40838  38.88630  10.05144  1.000 77.32516  ? 481 ASN D C   1 
ATOM   3360 O O   . ASN D 2 149 ? 29.51203  38.49883  10.44217  1.000 76.57718  ? 481 ASN D O   1 
ATOM   3361 C CB  . ASN D 2 149 ? 27.83476  39.36266  12.45589  1.000 74.01391  ? 481 ASN D CB  1 
ATOM   3362 C CG  . ASN D 2 149 ? 26.89681  40.05343  13.42846  1.000 83.44300  ? 481 ASN D CG  1 
ATOM   3363 O OD1 . ASN D 2 149 ? 26.50202  41.20062  13.21657  1.000 87.44377  ? 481 ASN D OD1 1 
ATOM   3364 N ND2 . ASN D 2 149 ? 26.52588  39.35260  14.49752  1.000 81.68927  ? 481 ASN D ND2 1 
ATOM   3365 N N   . GLY D 2 150 ? 27.98739  38.70888  8.79916   1.000 71.18480  ? 482 GLY D N   1 
ATOM   3366 C CA  . GLY D 2 150 ? 28.83458  38.08163  7.80523   1.000 59.09648  ? 482 GLY D CA  1 
ATOM   3367 C C   . GLY D 2 150 ? 29.17158  36.63541  8.07591   1.000 65.89917  ? 482 GLY D C   1 
ATOM   3368 O O   . GLY D 2 150 ? 30.11987  36.10996  7.48616   1.000 66.55937  ? 482 GLY D O   1 
ATOM   3369 N N   . VAL D 2 151 ? 28.42567  35.97291  8.95623   1.000 67.01025  ? 483 VAL D N   1 
ATOM   3370 C CA  . VAL D 2 151 ? 28.65517  34.57488  9.29741   1.000 67.79306  ? 483 VAL D CA  1 
ATOM   3371 C C   . VAL D 2 151 ? 27.38555  33.79280  8.99577   1.000 64.93449  ? 483 VAL D C   1 
ATOM   3372 O O   . VAL D 2 151 ? 26.29519  34.17051  9.44075   1.000 61.93105  ? 483 VAL D O   1 
ATOM   3373 C CB  . VAL D 2 151 ? 29.06237  34.40650  10.77230  1.000 69.14354  ? 483 VAL D CB  1 
ATOM   3374 C CG1 . VAL D 2 151 ? 29.34268  32.94293  11.07861  1.000 66.86371  ? 483 VAL D CG1 1 
ATOM   3375 C CG2 . VAL D 2 151 ? 30.27743  35.26580  11.08797  1.000 72.99577  ? 483 VAL D CG2 1 
ATOM   3376 N N   . ALA D 2 152 ? 27.52732  32.71141  8.23696   1.000 64.98523  ? 484 ALA D N   1 
ATOM   3377 C CA  . ALA D 2 152 ? 26.38962  31.85352  7.94938   1.000 56.54378  ? 484 ALA D CA  1 
ATOM   3378 C C   . ALA D 2 152 ? 25.99911  31.06055  9.18913   1.000 58.41721  ? 484 ALA D C   1 
ATOM   3379 O O   . ALA D 2 152 ? 26.85549  30.54779  9.91511   1.000 59.71035  ? 484 ALA D O   1 
ATOM   3380 C CB  . ALA D 2 152 ? 26.71538  30.90460  6.79843   1.000 52.41048  ? 484 ALA D CB  1 
ATOM   3381 N N   . GLY D 2 153 ? 24.69502  30.96531  9.42856   1.000 51.35079  ? 485 GLY D N   1 
ATOM   3382 C CA  . GLY D 2 153 ? 24.17961  30.20714  10.54794  1.000 50.86055  ? 485 GLY D CA  1 
ATOM   3383 C C   . GLY D 2 153 ? 22.68305  30.00211  10.45945  1.000 55.14337  ? 485 GLY D C   1 
ATOM   3384 O O   . GLY D 2 153 ? 22.12394  29.92885  9.35978   1.000 55.24292  ? 485 GLY D O   1 
ATOM   3385 N N   . VAL D 2 154 ? 22.02593  29.91173  11.61444  1.000 41.52432  ? 486 VAL D N   1 
ATOM   3386 C CA  . VAL D 2 154 ? 20.58296  29.70164  11.65948  1.000 44.15546  ? 486 VAL D CA  1 
ATOM   3387 C C   . VAL D 2 154 ? 19.88457  30.92533  11.08110  1.000 49.06908  ? 486 VAL D C   1 
ATOM   3388 O O   . VAL D 2 154 ? 20.08749  32.05179  11.54789  1.000 48.79835  ? 486 VAL D O   1 
ATOM   3389 C CB  . VAL D 2 154 ? 20.11727  29.41692  13.09285  1.000 53.61013  ? 486 VAL D CB  1 
ATOM   3390 C CG1 . VAL D 2 154 ? 18.60119  29.33573  13.15280  1.000 47.10462  ? 486 VAL D CG1 1 
ATOM   3391 C CG2 . VAL D 2 154 ? 20.75214  28.13038  13.60366  1.000 46.97790  ? 486 VAL D CG2 1 
ATOM   3392 N N   . ASN D 2 155 ? 19.06327  30.70703  10.05175  1.000 50.34199  ? 487 ASN D N   1 
ATOM   3393 C CA  . ASN D 2 155 ? 18.36886  31.77065  9.32643   1.000 46.17531  ? 487 ASN D CA  1 
ATOM   3394 C C   . ASN D 2 155 ? 19.33430  32.80125  8.74264   1.000 53.81211  ? 487 ASN D C   1 
ATOM   3395 O O   . ASN D 2 155 ? 18.93558  33.93165  8.44298   1.000 53.25782  ? 487 ASN D O   1 
ATOM   3396 C CB  . ASN D 2 155 ? 17.32063  32.45911  10.20946  1.000 52.63949  ? 487 ASN D CB  1 
ATOM   3397 C CG  . ASN D 2 155 ? 16.23327  31.50339  10.68246  1.000 61.36762  ? 487 ASN D CG  1 
ATOM   3398 O OD1 . ASN D 2 155 ? 15.97493  31.38662  11.88121  1.000 60.99838  ? 487 ASN D OD1 1 
ATOM   3399 N ND2 . ASN D 2 155 ? 15.59478  30.81201  9.74015   1.000 51.68216  ? 487 ASN D ND2 1 
ATOM   3400 N N   . CYS D 2 156 ? 20.60050  32.42243  8.56874   1.000 48.09545  ? 488 CYS D N   1 
ATOM   3401 C CA  . CYS D 2 156 ? 21.62415  33.27052  7.95781   1.000 48.91453  ? 488 CYS D CA  1 
ATOM   3402 C C   . CYS D 2 156 ? 22.32059  32.43695  6.88830   1.000 49.38138  ? 488 CYS D C   1 
ATOM   3403 O O   . CYS D 2 156 ? 23.23770  31.66839  7.19183   1.000 48.90401  ? 488 CYS D O   1 
ATOM   3404 C CB  . CYS D 2 156 ? 22.61212  33.78096  9.00065   1.000 58.72606  ? 488 CYS D CB  1 
ATOM   3405 S SG  . CYS D 2 156 ? 21.98172  35.15764  9.97801   1.000 61.64739  ? 488 CYS D SG  1 
ATOM   3406 N N   . TYR D 2 157 ? 21.89453  32.59326  5.63958   1.000 47.76081  ? 489 TYR D N   1 
ATOM   3407 C CA  . TYR D 2 157 ? 22.23994  31.65791  4.58034   1.000 52.78096  ? 489 TYR D CA  1 
ATOM   3408 C C   . TYR D 2 157 ? 23.13421  32.31195  3.53704   1.000 50.76687  ? 489 TYR D C   1 
ATOM   3409 O O   . TYR D 2 157 ? 22.87357  33.43844  3.09879   1.000 49.32095  ? 489 TYR D O   1 
ATOM   3410 C CB  . TYR D 2 157 ? 20.97120  31.11573  3.91235   1.000 47.90739  ? 489 TYR D CB  1 
ATOM   3411 C CG  . TYR D 2 157 ? 19.95072  30.59664  4.89961   1.000 46.15681  ? 489 TYR D CG  1 
ATOM   3412 C CD1 . TYR D 2 157 ? 20.22255  29.48354  5.68737   1.000 49.11645  ? 489 TYR D CD1 1 
ATOM   3413 C CD2 . TYR D 2 157 ? 18.71627  31.21873  5.04530   1.000 48.04602  ? 489 TYR D CD2 1 
ATOM   3414 C CE1 . TYR D 2 157 ? 19.29565  29.00285  6.59542   1.000 43.80487  ? 489 TYR D CE1 1 
ATOM   3415 C CE2 . TYR D 2 157 ? 17.78164  30.74434  5.94966   1.000 49.74987  ? 489 TYR D CE2 1 
ATOM   3416 C CZ  . TYR D 2 157 ? 18.07785  29.63462  6.72048   1.000 46.04779  ? 489 TYR D CZ  1 
ATOM   3417 O OH  . TYR D 2 157 ? 17.15692  29.15579  7.62331   1.000 49.36697  ? 489 TYR D OH  1 
ATOM   3418 N N   . PHE D 2 158 ? 24.18800  31.59805  3.14905   1.000 37.82742  ? 490 PHE D N   1 
ATOM   3419 C CA  . PHE D 2 158 ? 24.95548  31.98719  1.97743   1.000 51.28083  ? 490 PHE D CA  1 
ATOM   3420 C C   . PHE D 2 158 ? 24.01710  32.05600  0.77454   1.000 48.35217  ? 490 PHE D C   1 
ATOM   3421 O O   . PHE D 2 158 ? 23.26500  31.10392  0.52631   1.000 47.88493  ? 490 PHE D O   1 
ATOM   3422 C CB  . PHE D 2 158 ? 26.08861  30.99585  1.71619   1.000 46.14546  ? 490 PHE D CB  1 
ATOM   3423 C CG  . PHE D 2 158 ? 27.10791  31.48897  0.72715   1.000 49.70103  ? 490 PHE D CG  1 
ATOM   3424 C CD1 . PHE D 2 158 ? 28.03401  32.45147  1.09704   1.000 50.53857  ? 490 PHE D CD1 1 
ATOM   3425 C CD2 . PHE D 2 158 ? 27.14669  30.98750  -0.56502  1.000 46.86066  ? 490 PHE D CD2 1 
ATOM   3426 C CE1 . PHE D 2 158 ? 28.97659  32.91228  0.19654   1.000 53.68521  ? 490 PHE D CE1 1 
ATOM   3427 C CE2 . PHE D 2 158 ? 28.08850  31.44373  -1.47355  1.000 45.87467  ? 490 PHE D CE2 1 
ATOM   3428 C CZ  . PHE D 2 158 ? 29.00542  32.40788  -1.09084  1.000 45.96277  ? 490 PHE D CZ  1 
ATOM   3429 N N   . PRO D 2 159 ? 24.01897  33.15352  0.01591   1.000 49.47067  ? 491 PRO D N   1 
ATOM   3430 C CA  . PRO D 2 159 ? 22.94542  33.36188  -0.96825  1.000 47.31948  ? 491 PRO D CA  1 
ATOM   3431 C C   . PRO D 2 159 ? 23.04894  32.49068  -2.21332  1.000 39.60323  ? 491 PRO D C   1 
ATOM   3432 O O   . PRO D 2 159 ? 22.04667  32.34890  -2.92313  1.000 43.05710  ? 491 PRO D O   1 
ATOM   3433 C CB  . PRO D 2 159 ? 23.08365  34.84749  -1.31882  1.000 40.64472  ? 491 PRO D CB  1 
ATOM   3434 C CG  . PRO D 2 159 ? 24.53483  35.12279  -1.13131  1.000 46.30797  ? 491 PRO D CG  1 
ATOM   3435 C CD  . PRO D 2 159 ? 24.96692  34.27966  0.04526   1.000 49.80190  ? 491 PRO D CD  1 
ATOM   3436 N N   . LEU D 2 160 ? 24.20384  31.90663  -2.51020  1.000 43.99883  ? 492 LEU D N   1 
ATOM   3437 C CA  . LEU D 2 160 ? 24.36989  31.12748  -3.72917  1.000 41.91826  ? 492 LEU D CA  1 
ATOM   3438 C C   . LEU D 2 160 ? 24.37644  29.63288  -3.42595  1.000 44.56561  ? 492 LEU D C   1 
ATOM   3439 O O   . LEU D 2 160 ? 24.86786  29.18915  -2.38517  1.000 40.84725  ? 492 LEU D O   1 
ATOM   3440 C CB  . LEU D 2 160 ? 25.66202  31.50490  -4.45680  1.000 36.21994  ? 492 LEU D CB  1 
ATOM   3441 C CG  . LEU D 2 160 ? 25.88203  32.97636  -4.80821  1.000 42.64302  ? 492 LEU D CG  1 
ATOM   3442 C CD1 . LEU D 2 160 ? 27.20866  33.15224  -5.53500  1.000 46.10590  ? 492 LEU D CD1 1 
ATOM   3443 C CD2 . LEU D 2 160 ? 24.73707  33.53422  -5.64048  1.000 40.45249  ? 492 LEU D CD2 1 
ATOM   3444 N N   . GLN D 2 161 ? 23.82915  28.86194  -4.36265  1.000 37.85721  ? 493 GLN D N   1 
ATOM   3445 C CA  . GLN D 2 161 ? 23.80369  27.40721  -4.31142  1.000 36.33594  ? 493 GLN D CA  1 
ATOM   3446 C C   . GLN D 2 161 ? 24.47938  26.84837  -5.55423  1.000 42.29691  ? 493 GLN D C   1 
ATOM   3447 O O   . GLN D 2 161 ? 24.33215  27.40477  -6.64626  1.000 40.73982  ? 493 GLN D O   1 
ATOM   3448 C CB  . GLN D 2 161 ? 22.36551  26.88099  -4.24101  1.000 38.66926  ? 493 GLN D CB  1 
ATOM   3449 C CG  . GLN D 2 161 ? 21.56754  27.40376  -3.06671  1.000 45.82726  ? 493 GLN D CG  1 
ATOM   3450 C CD  . GLN D 2 161 ? 21.96222  26.74126  -1.76756  1.000 43.47383  ? 493 GLN D CD  1 
ATOM   3451 O OE1 . GLN D 2 161 ? 22.50365  25.63403  -1.76378  1.000 44.17942  ? 493 GLN D OE1 1 
ATOM   3452 N NE2 . GLN D 2 161 ? 21.69460  27.41408  -0.65343  1.000 45.64234  ? 493 GLN D NE2 1 
ATOM   3453 N N   . SER D 2 162 ? 25.20957  25.74515  -5.39019  1.000 36.29762  ? 494 SER D N   1 
ATOM   3454 C CA  . SER D 2 162 ? 25.80076  25.03468  -6.51763  1.000 34.93863  ? 494 SER D CA  1 
ATOM   3455 C C   . SER D 2 162 ? 24.80609  24.02948  -7.08082  1.000 38.15649  ? 494 SER D C   1 
ATOM   3456 O O   . SER D 2 162 ? 24.03246  23.42115  -6.33793  1.000 38.96560  ? 494 SER D O   1 
ATOM   3457 C CB  . SER D 2 162 ? 27.08345  24.30786  -6.10733  1.000 35.86160  ? 494 SER D CB  1 
ATOM   3458 O OG  . SER D 2 162 ? 28.05405  25.20690  -5.60027  1.000 45.24076  ? 494 SER D OG  1 
ATOM   3459 N N   . TYR D 2 163 ? 24.84471  23.84721  -8.40321  1.000 36.73224  ? 495 TYR D N   1 
ATOM   3460 C CA  . TYR D 2 163 ? 23.89346  22.95374  -9.05752  1.000 32.62329  ? 495 TYR D CA  1 
ATOM   3461 C C   . TYR D 2 163 ? 24.23652  21.48420  -8.82798  1.000 35.40615  ? 495 TYR D C   1 
ATOM   3462 O O   . TYR D 2 163 ? 23.33647  20.65293  -8.65412  1.000 35.65491  ? 495 TYR D O   1 
ATOM   3463 C CB  . TYR D 2 163 ? 23.85176  23.24786  -10.55180 1.000 34.91855  ? 495 TYR D CB  1 
ATOM   3464 C CG  . TYR D 2 163 ? 22.90624  24.34852  -10.97676 1.000 31.39764  ? 495 TYR D CG  1 
ATOM   3465 C CD1 . TYR D 2 163 ? 21.52941  24.16843  -10.91556 1.000 33.12077  ? 495 TYR D CD1 1 
ATOM   3466 C CD2 . TYR D 2 163 ? 23.39063  25.54990  -11.48233 1.000 36.42190  ? 495 TYR D CD2 1 
ATOM   3467 C CE1 . TYR D 2 163 ? 20.66078  25.16189  -11.31906 1.000 34.76677  ? 495 TYR D CE1 1 
ATOM   3468 C CE2 . TYR D 2 163 ? 22.52938  26.55463  -11.89418 1.000 35.44936  ? 495 TYR D CE2 1 
ATOM   3469 C CZ  . TYR D 2 163 ? 21.16550  26.35303  -11.81154 1.000 40.00677  ? 495 TYR D CZ  1 
ATOM   3470 O OH  . TYR D 2 163 ? 20.29915  27.34026  -12.21733 1.000 36.30755  ? 495 TYR D OH  1 
ATOM   3471 N N   . GLY D 2 164 ? 25.51983  21.13776  -8.86290  1.000 37.34550  ? 496 GLY D N   1 
ATOM   3472 C CA  . GLY D 2 164 ? 25.94262  19.75787  -8.66381  1.000 35.74982  ? 496 GLY D CA  1 
ATOM   3473 C C   . GLY D 2 164 ? 25.56908  18.80270  -9.78013  1.000 43.28562  ? 496 GLY D C   1 
ATOM   3474 O O   . GLY D 2 164 ? 25.26905  17.63070  -9.51039  1.000 41.62699  ? 496 GLY D O   1 
ATOM   3475 N N   . PHE D 2 165 ? 25.59962  19.26947  -11.03108 1.000 36.13921  ? 497 PHE D N   1 
ATOM   3476 C CA  . PHE D 2 165 ? 25.14106  18.47095  -12.16624 1.000 39.18431  ? 497 PHE D CA  1 
ATOM   3477 C C   . PHE D 2 165 ? 25.89586  17.14736  -12.28571 1.000 38.66577  ? 497 PHE D C   1 
ATOM   3478 O O   . PHE D 2 165 ? 27.12937  17.11899  -12.29067 1.000 36.64019  ? 497 PHE D O   1 
ATOM   3479 C CB  . PHE D 2 165 ? 25.30918  19.26306  -13.46681 1.000 36.13642  ? 497 PHE D CB  1 
ATOM   3480 C CG  . PHE D 2 165 ? 24.45113  20.49531  -13.56048 1.000 37.61093  ? 497 PHE D CG  1 
ATOM   3481 C CD1 . PHE D 2 165 ? 23.06718  20.39419  -13.58877 1.000 34.14976  ? 497 PHE D CD1 1 
ATOM   3482 C CD2 . PHE D 2 165 ? 25.03063  21.75173  -13.66537 1.000 35.27101  ? 497 PHE D CD2 1 
ATOM   3483 C CE1 . PHE D 2 165 ? 22.27597  21.52359  -13.69332 1.000 35.75035  ? 497 PHE D CE1 1 
ATOM   3484 C CE2 . PHE D 2 165 ? 24.24561  22.88917  -13.78683 1.000 36.75207  ? 497 PHE D CE2 1 
ATOM   3485 C CZ  . PHE D 2 165 ? 22.86546  22.77497  -13.79630 1.000 32.88013  ? 497 PHE D CZ  1 
ATOM   3486 N N   . ARG D 2 166 ? 25.14697  16.05467  -12.42356 1.000 37.46900  ? 498 ARG D N   1 
ATOM   3487 C CA  . ARG D 2 166 ? 25.68484  14.73106  -12.70049 1.000 39.41356  ? 498 ARG D CA  1 
ATOM   3488 C C   . ARG D 2 166 ? 25.02504  14.15084  -13.94258 1.000 40.80539  ? 498 ARG D C   1 
ATOM   3489 O O   . ARG D 2 166 ? 23.84952  14.42413  -14.21091 1.000 38.04347  ? 498 ARG D O   1 
ATOM   3490 C CB  . ARG D 2 166 ? 25.46778  13.77600  -11.51768 1.000 39.84033  ? 498 ARG D CB  1 
ATOM   3491 C CG  . ARG D 2 166 ? 26.12645  14.22950  -10.23806 1.000 46.63265  ? 498 ARG D CG  1 
ATOM   3492 C CD  . ARG D 2 166 ? 25.99129  13.18313  -9.15347  1.000 45.23588  ? 498 ARG D CD  1 
ATOM   3493 N NE  . ARG D 2 166 ? 26.58601  13.64387  -7.90801  1.000 46.64245  ? 498 ARG D NE  1 
ATOM   3494 C CZ  . ARG D 2 166 ? 26.94834  12.84675  -6.91392  1.000 60.36523  ? 498 ARG D CZ  1 
ATOM   3495 N NH1 . ARG D 2 166 ? 26.79424  11.53403  -6.99146  1.000 53.38364  ? 498 ARG D NH1 1 
ATOM   3496 N NH2 . ARG D 2 166 ? 27.48178  13.38026  -5.81682  1.000 58.14073  ? 498 ARG D NH2 1 
ATOM   3497 N N   . PRO D 2 167 ? 25.75134  13.32828  -14.70811 1.000 40.99138  ? 499 PRO D N   1 
ATOM   3498 C CA  . PRO D 2 167 ? 25.20998  12.85956  -15.99715 1.000 42.45035  ? 499 PRO D CA  1 
ATOM   3499 C C   . PRO D 2 167 ? 23.95795  12.01100  -15.86951 1.000 43.12186  ? 499 PRO D C   1 
ATOM   3500 O O   . PRO D 2 167 ? 23.16742  11.94902  -16.81920 1.000 41.31051  ? 499 PRO D O   1 
ATOM   3501 C CB  . PRO D 2 167 ? 26.37159  12.04972  -16.59113 1.000 43.61696  ? 499 PRO D CB  1 
ATOM   3502 C CG  . PRO D 2 167 ? 27.59101  12.49145  -15.82907 1.000 46.12475  ? 499 PRO D CG  1 
ATOM   3503 C CD  . PRO D 2 167 ? 27.11358  12.82598  -14.46337 1.000 38.04859  ? 499 PRO D CD  1 
ATOM   3504 N N   . THR D 2 168 ? 23.75380  11.35514  -14.72908 1.000 40.79949  ? 500 THR D N   1 
ATOM   3505 C CA  . THR D 2 168 ? 22.63105  10.44817  -14.52357 1.000 41.79610  ? 500 THR D CA  1 
ATOM   3506 C C   . THR D 2 168 ? 21.38277  11.14666  -14.00278 1.000 41.14903  ? 500 THR D C   1 
ATOM   3507 O O   . THR D 2 168 ? 20.37774  10.47523  -13.74682 1.000 38.15406  ? 500 THR D O   1 
ATOM   3508 C CB  . THR D 2 168 ? 23.02852  9.33175   -13.55184 1.000 42.21737  ? 500 THR D CB  1 
ATOM   3509 O OG1 . THR D 2 168 ? 23.63040  9.90696   -12.38584 1.000 39.70333  ? 500 THR D OG1 1 
ATOM   3510 C CG2 . THR D 2 168 ? 24.01643  8.38046   -14.21011 1.000 37.20261  ? 500 THR D CG2 1 
ATOM   3511 N N   . TYR D 2 169 ? 21.42275  12.46553  -13.83273 1.000 38.06546  ? 501 TYR D N   1 
ATOM   3512 C CA  . TYR D 2 169 ? 20.24589  13.20030  -13.39667 1.000 37.53821  ? 501 TYR D CA  1 
ATOM   3513 C C   . TYR D 2 169 ? 19.12477  13.08048  -14.42716 1.000 36.31758  ? 501 TYR D C   1 
ATOM   3514 O O   . TYR D 2 169 ? 19.35835  12.86470  -15.61895 1.000 31.52840  ? 501 TYR D O   1 
ATOM   3515 C CB  . TYR D 2 169 ? 20.58508  14.67648  -13.17601 1.000 34.19687  ? 501 TYR D CB  1 
ATOM   3516 C CG  . TYR D 2 169 ? 21.26002  14.99203  -11.85464 1.000 38.27398  ? 501 TYR D CG  1 
ATOM   3517 C CD1 . TYR D 2 169 ? 21.65698  13.98102  -10.98966 1.000 37.88950  ? 501 TYR D CD1 1 
ATOM   3518 C CD2 . TYR D 2 169 ? 21.48476  16.30547  -11.46930 1.000 35.16637  ? 501 TYR D CD2 1 
ATOM   3519 C CE1 . TYR D 2 169 ? 22.26681  14.26977  -9.77830  1.000 39.58973  ? 501 TYR D CE1 1 
ATOM   3520 C CE2 . TYR D 2 169 ? 22.08773  16.60565  -10.26116 1.000 39.46298  ? 501 TYR D CE2 1 
ATOM   3521 C CZ  . TYR D 2 169 ? 22.47844  15.58343  -9.41925  1.000 41.74442  ? 501 TYR D CZ  1 
ATOM   3522 O OH  . TYR D 2 169 ? 23.08132  15.88151  -8.21793  1.000 37.24527  ? 501 TYR D OH  1 
ATOM   3523 N N   . GLY D 2 170 ? 17.88853  13.21974  -13.95187 1.000 34.42904  ? 502 GLY D N   1 
ATOM   3524 C CA  . GLY D 2 170 ? 16.77525  13.39641  -14.86319 1.000 36.08044  ? 502 GLY D CA  1 
ATOM   3525 C C   . GLY D 2 170 ? 16.96157  14.62182  -15.73803 1.000 39.51460  ? 502 GLY D C   1 
ATOM   3526 O O   . GLY D 2 170 ? 17.73677  15.52775  -15.42508 1.000 38.60770  ? 502 GLY D O   1 
ATOM   3527 N N   . VAL D 2 171 ? 16.23323  14.64948  -16.85923 1.000 39.41555  ? 503 VAL D N   1 
ATOM   3528 C CA  . VAL D 2 171 ? 16.46112  15.69448  -17.85874 1.000 39.03648  ? 503 VAL D CA  1 
ATOM   3529 C C   . VAL D 2 171 ? 16.15092  17.07151  -17.28172 1.000 38.07428  ? 503 VAL D C   1 
ATOM   3530 O O   . VAL D 2 171 ? 16.87874  18.04171  -17.52868 1.000 37.55807  ? 503 VAL D O   1 
ATOM   3531 C CB  . VAL D 2 171 ? 15.64599  15.41503  -19.13631 1.000 46.12122  ? 503 VAL D CB  1 
ATOM   3532 C CG1 . VAL D 2 171 ? 14.16862  15.23031  -18.80449 1.000 49.82190  ? 503 VAL D CG1 1 
ATOM   3533 C CG2 . VAL D 2 171 ? 15.83519  16.54797  -20.13308 1.000 48.63833  ? 503 VAL D CG2 1 
ATOM   3534 N N   . GLY D 2 172 ? 15.08288  17.17689  -16.48810 1.000 40.41371  ? 504 GLY D N   1 
ATOM   3535 C CA  . GLY D 2 172 ? 14.75439  18.43969  -15.85292 1.000 37.54589  ? 504 GLY D CA  1 
ATOM   3536 C C   . GLY D 2 172 ? 15.84729  18.97816  -14.95271 1.000 39.74370  ? 504 GLY D C   1 
ATOM   3537 O O   . GLY D 2 172 ? 15.90022  20.18922  -14.71615 1.000 37.23886  ? 504 GLY D O   1 
ATOM   3538 N N   . HIS D 2 173 ? 16.72689  18.11091  -14.45394 1.000 35.45223  ? 505 HIS D N   1 
ATOM   3539 C CA  . HIS D 2 173 ? 17.82367  18.51892  -13.58747 1.000 36.85356  ? 505 HIS D CA  1 
ATOM   3540 C C   . HIS D 2 173 ? 19.17042  18.54483  -14.30138 1.000 35.71486  ? 505 HIS D C   1 
ATOM   3541 O O   . HIS D 2 173 ? 20.18405  18.86885  -13.67194 1.000 36.91397  ? 505 HIS D O   1 
ATOM   3542 C CB  . HIS D 2 173 ? 17.89995  17.59420  -12.36940 1.000 34.87388  ? 505 HIS D CB  1 
ATOM   3543 C CG  . HIS D 2 173 ? 16.69335  17.65831  -11.48707 1.000 37.93038  ? 505 HIS D CG  1 
ATOM   3544 N ND1 . HIS D 2 173 ? 16.05668  16.53187  -11.01558 1.000 47.61985  ? 505 HIS D ND1 1 
ATOM   3545 C CD2 . HIS D 2 173 ? 16.01077  18.71380  -10.98285 1.000 40.61606  ? 505 HIS D CD2 1 
ATOM   3546 C CE1 . HIS D 2 173 ? 15.03299  16.89014  -10.26035 1.000 49.42648  ? 505 HIS D CE1 1 
ATOM   3547 N NE2 . HIS D 2 173 ? 14.98195  18.20913  -10.22568 1.000 39.73089  ? 505 HIS D NE2 1 
ATOM   3548 N N   . GLN D 2 174 ? 19.20699  18.21674  -15.59291 1.000 31.50856  ? 506 GLN D N   1 
ATOM   3549 C CA  . GLN D 2 174 ? 20.44044  18.26133  -16.36611 1.000 36.51687  ? 506 GLN D CA  1 
ATOM   3550 C C   . GLN D 2 174 ? 20.77466  19.69843  -16.76356 1.000 35.49154  ? 506 GLN D C   1 
ATOM   3551 O O   . GLN D 2 174 ? 19.88300  20.54488  -16.86337 1.000 34.87493  ? 506 GLN D O   1 
ATOM   3552 C CB  . GLN D 2 174 ? 20.32212  17.39355  -17.61843 1.000 32.58162  ? 506 GLN D CB  1 
ATOM   3553 C CG  . GLN D 2 174 ? 20.47873  15.90262  -17.34788 1.000 35.34809  ? 506 GLN D CG  1 
ATOM   3554 C CD  . GLN D 2 174 ? 20.42033  15.07221  -18.61366 1.000 38.22928  ? 506 GLN D CD  1 
ATOM   3555 O OE1 . GLN D 2 174 ? 20.42773  15.60771  -19.72270 1.000 36.70332  ? 506 GLN D OE1 1 
ATOM   3556 N NE2 . GLN D 2 174 ? 20.35762  13.75530  -18.45445 1.000 38.15762  ? 506 GLN D NE2 1 
ATOM   3557 N N   . PRO D 2 175 ? 22.05291  19.99951  -16.99131 1.000 37.93155  ? 507 PRO D N   1 
ATOM   3558 C CA  . PRO D 2 175 ? 22.42576  21.37123  -17.35350 1.000 41.17443  ? 507 PRO D CA  1 
ATOM   3559 C C   . PRO D 2 175 ? 22.04159  21.70311  -18.78952 1.000 38.06078  ? 507 PRO D C   1 
ATOM   3560 O O   . PRO D 2 175 ? 22.15838  20.87495  -19.69666 1.000 35.30063  ? 507 PRO D O   1 
ATOM   3561 C CB  . PRO D 2 175 ? 23.94673  21.38190  -17.16400 1.000 38.05725  ? 507 PRO D CB  1 
ATOM   3562 C CG  . PRO D 2 175 ? 24.35056  19.97243  -17.44091 1.000 41.90856  ? 507 PRO D CG  1 
ATOM   3563 C CD  . PRO D 2 175 ? 23.22945  19.11532  -16.90510 1.000 34.41839  ? 507 PRO D CD  1 
ATOM   3564 N N   . TYR D 2 176 ? 21.58033  22.93514  -18.98780 1.000 34.19484  ? 508 TYR D N   1 
ATOM   3565 C CA  . TYR D 2 176 ? 21.28770  23.45823  -20.31537 1.000 38.03845  ? 508 TYR D CA  1 
ATOM   3566 C C   . TYR D 2 176 ? 22.04886  24.75814  -20.50760 1.000 33.63354  ? 508 TYR D C   1 
ATOM   3567 O O   . TYR D 2 176 ? 22.05468  25.61780  -19.62077 1.000 34.75050  ? 508 TYR D O   1 
ATOM   3568 C CB  . TYR D 2 176 ? 19.77939  23.68052  -20.51510 1.000 32.89295  ? 508 TYR D CB  1 
ATOM   3569 C CG  . TYR D 2 176 ? 19.06119  22.41894  -20.91802 1.000 38.72923  ? 508 TYR D CG  1 
ATOM   3570 C CD1 . TYR D 2 176 ? 18.93862  21.35573  -20.02734 1.000 37.11058  ? 508 TYR D CD1 1 
ATOM   3571 C CD2 . TYR D 2 176 ? 18.52615  22.27540  -22.19510 1.000 35.92808  ? 508 TYR D CD2 1 
ATOM   3572 C CE1 . TYR D 2 176 ? 18.29908  20.19063  -20.39107 1.000 38.62194  ? 508 TYR D CE1 1 
ATOM   3573 C CE2 . TYR D 2 176 ? 17.88363  21.10986  -22.57103 1.000 39.48919  ? 508 TYR D CE2 1 
ATOM   3574 C CZ  . TYR D 2 176 ? 17.77477  20.07050  -21.66427 1.000 42.45484  ? 508 TYR D CZ  1 
ATOM   3575 O OH  . TYR D 2 176 ? 17.14157  18.90172  -22.02610 1.000 39.96443  ? 508 TYR D OH  1 
ATOM   3576 N N   . ARG D 2 177 ? 22.69904  24.89608  -21.65452 1.000 37.71715  ? 509 ARG D N   1 
ATOM   3577 C CA  . ARG D 2 177 ? 23.34336  26.14991  -22.00977 1.000 37.14913  ? 509 ARG D CA  1 
ATOM   3578 C C   . ARG D 2 177 ? 22.33192  27.04089  -22.71178 1.000 31.93291  ? 509 ARG D C   1 
ATOM   3579 O O   . ARG D 2 177 ? 21.57240  26.57392  -23.56443 1.000 35.25718  ? 509 ARG D O   1 
ATOM   3580 C CB  . ARG D 2 177 ? 24.56578  25.90416  -22.89203 1.000 38.53852  ? 509 ARG D CB  1 
ATOM   3581 C CG  . ARG D 2 177 ? 25.71422  25.30480  -22.11129 1.000 38.77883  ? 509 ARG D CG  1 
ATOM   3582 C CD  . ARG D 2 177 ? 26.94935  25.08893  -22.95413 1.000 37.01774  ? 509 ARG D CD  1 
ATOM   3583 N NE  . ARG D 2 177 ? 28.04784  24.63190  -22.11518 1.000 36.93519  ? 509 ARG D NE  1 
ATOM   3584 C CZ  . ARG D 2 177 ? 29.32637  24.68710  -22.45597 1.000 43.12619  ? 509 ARG D CZ  1 
ATOM   3585 N NH1 . ARG D 2 177 ? 29.70831  25.16545  -23.63032 1.000 44.64727  ? 509 ARG D NH1 1 
ATOM   3586 N NH2 . ARG D 2 177 ? 30.24433  24.26166  -21.59266 1.000 39.38785  ? 509 ARG D NH2 1 
ATOM   3587 N N   . VAL D 2 178 ? 22.31287  28.31507  -22.33514 1.000 32.56773  ? 510 VAL D N   1 
ATOM   3588 C CA  . VAL D 2 178 ? 21.33658  29.27485  -22.82994 1.000 34.54576  ? 510 VAL D CA  1 
ATOM   3589 C C   . VAL D 2 178 ? 22.08428  30.45944  -23.42052 1.000 38.88911  ? 510 VAL D C   1 
ATOM   3590 O O   . VAL D 2 178 ? 23.07268  30.92947  -22.84569 1.000 36.87287  ? 510 VAL D O   1 
ATOM   3591 C CB  . VAL D 2 178 ? 20.38356  29.73946  -21.70834 1.000 36.23538  ? 510 VAL D CB  1 
ATOM   3592 C CG1 . VAL D 2 178 ? 19.34323  30.69727  -22.25439 1.000 32.97095  ? 510 VAL D CG1 1 
ATOM   3593 C CG2 . VAL D 2 178 ? 19.72140  28.54270  -21.03862 1.000 34.12176  ? 510 VAL D CG2 1 
ATOM   3594 N N   . VAL D 2 179 ? 21.61878  30.93275  -24.57362 1.000 37.94048  ? 511 VAL D N   1 
ATOM   3595 C CA  . VAL D 2 179 ? 22.10892  32.16465  -25.17932 1.000 37.58837  ? 511 VAL D CA  1 
ATOM   3596 C C   . VAL D 2 179 ? 20.91247  33.06653  -25.44416 1.000 35.95654  ? 511 VAL D C   1 
ATOM   3597 O O   . VAL D 2 179 ? 19.89930  32.61652  -25.99190 1.000 37.19439  ? 511 VAL D O   1 
ATOM   3598 C CB  . VAL D 2 179 ? 22.89159  31.90225  -26.48040 1.000 43.30072  ? 511 VAL D CB  1 
ATOM   3599 C CG1 . VAL D 2 179 ? 23.24748  33.22064  -27.16035 1.000 36.07877  ? 511 VAL D CG1 1 
ATOM   3600 C CG2 . VAL D 2 179 ? 24.15107  31.09943  -26.18821 1.000 36.59045  ? 511 VAL D CG2 1 
ATOM   3601 N N   . VAL D 2 180 ? 21.02404  34.33026  -25.04429 1.000 32.82730  ? 512 VAL D N   1 
ATOM   3602 C CA  . VAL D 2 180 ? 19.97376  35.32300  -25.23988 1.000 33.11711  ? 512 VAL D CA  1 
ATOM   3603 C C   . VAL D 2 180 ? 20.52758  36.41171  -26.14776 1.000 37.22600  ? 512 VAL D C   1 
ATOM   3604 O O   . VAL D 2 180 ? 21.54268  37.04041  -25.82172 1.000 39.45956  ? 512 VAL D O   1 
ATOM   3605 C CB  . VAL D 2 180 ? 19.48838  35.91437  -23.90626 1.000 35.82635  ? 512 VAL D CB  1 
ATOM   3606 C CG1 . VAL D 2 180 ? 18.33237  36.87766  -24.14003 1.000 34.51142  ? 512 VAL D CG1 1 
ATOM   3607 C CG2 . VAL D 2 180 ? 19.07745  34.80314  -22.94863 1.000 32.85128  ? 512 VAL D CG2 1 
ATOM   3608 N N   . LEU D 2 181 ? 19.86875  36.63235  -27.28230 1.000 38.83266  ? 513 LEU D N   1 
ATOM   3609 C CA  . LEU D 2 181 ? 20.27131  37.66012  -28.23697 1.000 40.34210  ? 513 LEU D CA  1 
ATOM   3610 C C   . LEU D 2 181 ? 19.34221  38.86093  -28.10351 1.000 40.23281  ? 513 LEU D C   1 
ATOM   3611 O O   . LEU D 2 181 ? 18.12800  38.73195  -28.28976 1.000 41.03409  ? 513 LEU D O   1 
ATOM   3612 C CB  . LEU D 2 181 ? 20.24730  37.12342  -29.66856 1.000 34.22422  ? 513 LEU D CB  1 
ATOM   3613 C CG  . LEU D 2 181 ? 21.17562  35.94841  -29.99999 1.000 37.35697  ? 513 LEU D CG  1 
ATOM   3614 C CD1 . LEU D 2 181 ? 21.07105  35.57181  -31.47110 1.000 38.45636  ? 513 LEU D CD1 1 
ATOM   3615 C CD2 . LEU D 2 181 ? 22.61664  36.25621  -29.62031 1.000 37.73529  ? 513 LEU D CD2 1 
ATOM   3616 N N   . SER D 2 182 ? 19.91357  40.01701  -27.77058 1.000 41.54421  ? 514 SER D N   1 
ATOM   3617 C CA  . SER D 2 182 ? 19.19744  41.28638  -27.69175 1.000 41.84028  ? 514 SER D CA  1 
ATOM   3618 C C   . SER D 2 182 ? 19.67547  42.19930  -28.81342 1.000 44.99376  ? 514 SER D C   1 
ATOM   3619 O O   . SER D 2 182 ? 20.88340  42.32856  -29.04116 1.000 43.08070  ? 514 SER D O   1 
ATOM   3620 C CB  . SER D 2 182 ? 19.42159  41.97051  -26.33987 1.000 36.34888  ? 514 SER D CB  1 
ATOM   3621 O OG  . SER D 2 182 ? 18.78343  41.26611  -25.29105 1.000 50.81453  ? 514 SER D OG  1 
ATOM   3622 N N   . PHE D 2 183 ? 18.73395  42.83922  -29.50069 1.000 44.06359  ? 515 PHE D N   1 
ATOM   3623 C CA  . PHE D 2 183 ? 19.03166  43.67918  -30.65792 1.000 44.96211  ? 515 PHE D CA  1 
ATOM   3624 C C   . PHE D 2 183 ? 18.74498  45.13307  -30.30277 1.000 43.81781  ? 515 PHE D C   1 
ATOM   3625 O O   . PHE D 2 183 ? 17.58213  45.53675  -30.19780 1.000 48.60008  ? 515 PHE D O   1 
ATOM   3626 C CB  . PHE D 2 183 ? 18.22647  43.21674  -31.86451 1.000 39.27427  ? 515 PHE D CB  1 
ATOM   3627 C CG  . PHE D 2 183 ? 18.50424  41.79597  -32.24490 1.000 45.46069  ? 515 PHE D CG  1 
ATOM   3628 C CD1 . PHE D 2 183 ? 17.79385  40.76075  -31.66103 1.000 47.28200  ? 515 PHE D CD1 1 
ATOM   3629 C CD2 . PHE D 2 183 ? 19.49229  41.49011  -33.16550 1.000 47.21097  ? 515 PHE D CD2 1 
ATOM   3630 C CE1 . PHE D 2 183 ? 18.04983  39.44643  -31.99795 1.000 41.20810  ? 515 PHE D CE1 1 
ATOM   3631 C CE2 . PHE D 2 183 ? 19.75647  40.17410  -33.50969 1.000 51.96969  ? 515 PHE D CE2 1 
ATOM   3632 C CZ  . PHE D 2 183 ? 19.03267  39.15046  -32.92347 1.000 49.70052  ? 515 PHE D CZ  1 
ATOM   3633 N N   . GLU D 2 184 ? 19.80792  45.91127  -30.11791 1.000 42.56695  ? 516 GLU D N   1 
ATOM   3634 C CA  . GLU D 2 184 ? 19.71490  47.28115  -29.63267 1.000 45.82335  ? 516 GLU D CA  1 
ATOM   3635 C C   . GLU D 2 184 ? 19.71674  48.24814  -30.80752 1.000 50.44074  ? 516 GLU D C   1 
ATOM   3636 O O   . GLU D 2 184 ? 20.58658  48.16719  -31.68105 1.000 50.23694  ? 516 GLU D O   1 
ATOM   3637 C CB  . GLU D 2 184 ? 20.87764  47.59904  -28.69410 1.000 37.88785  ? 516 GLU D CB  1 
ATOM   3638 C CG  . GLU D 2 184 ? 20.75298  48.93046  -27.98334 1.000 43.62638  ? 516 GLU D CG  1 
ATOM   3639 C CD  . GLU D 2 184 ? 21.96945  49.25061  -27.13903 1.000 49.21795  ? 516 GLU D CD  1 
ATOM   3640 O OE1 . GLU D 2 184 ? 23.10564  49.09482  -27.63819 1.000 50.74351  ? 516 GLU D OE1 1 
ATOM   3641 O OE2 . GLU D 2 184 ? 21.78851  49.65064  -25.97087 1.000 59.51883  ? 516 GLU D OE2 1 
ATOM   3642 N N   . LEU D 2 185 ? 18.75222  49.16746  -30.81590 1.000 53.48803  ? 517 LEU D N   1 
ATOM   3643 C CA  . LEU D 2 185 ? 18.61522  50.17347  -31.86890 1.000 51.82142  ? 517 LEU D CA  1 
ATOM   3644 C C   . LEU D 2 185 ? 18.60680  51.54602  -31.20093 1.000 50.75577  ? 517 LEU D C   1 
ATOM   3645 O O   . LEU D 2 185 ? 17.56374  52.00375  -30.72477 1.000 52.65667  ? 517 LEU D O   1 
ATOM   3646 C CB  . LEU D 2 185 ? 17.34961  49.93935  -32.69045 1.000 44.77570  ? 517 LEU D CB  1 
ATOM   3647 C CG  . LEU D 2 185 ? 17.32573  50.46265  -34.13031 1.000 59.61552  ? 517 LEU D CG  1 
ATOM   3648 C CD1 . LEU D 2 185 ? 17.14750  51.97465  -34.18425 1.000 64.80155  ? 517 LEU D CD1 1 
ATOM   3649 C CD2 . LEU D 2 185 ? 18.59308  50.04731  -34.86542 1.000 53.33466  ? 517 LEU D CD2 1 
ATOM   3650 N N   . LEU D 2 186 ? 19.76776  52.19317  -31.16258 1.000 47.39175  ? 518 LEU D N   1 
ATOM   3651 C CA  . LEU D 2 186 ? 19.91645  53.52727  -30.60171 1.000 49.77328  ? 518 LEU D CA  1 
ATOM   3652 C C   . LEU D 2 186 ? 20.00074  54.56756  -31.71683 1.000 53.56018  ? 518 LEU D C   1 
ATOM   3653 O O   . LEU D 2 186 ? 20.04314  54.24520  -32.90667 1.000 45.71100  ? 518 LEU D O   1 
ATOM   3654 C CB  . LEU D 2 186 ? 21.16201  53.60195  -29.71382 1.000 44.62006  ? 518 LEU D CB  1 
ATOM   3655 C CG  . LEU D 2 186 ? 21.30982  52.58279  -28.58392 1.000 53.69428  ? 518 LEU D CG  1 
ATOM   3656 C CD1 . LEU D 2 186 ? 22.62808  52.79247  -27.85223 1.000 42.69110  ? 518 LEU D CD1 1 
ATOM   3657 C CD2 . LEU D 2 186 ? 20.13800  52.66374  -27.62005 1.000 45.72750  ? 518 LEU D CD2 1 
ATOM   3658 N N   . HIS D 2 187 ? 20.02641  55.83894  -31.31000 1.000 48.65271  ? 519 HIS D N   1 
ATOM   3659 C CA  . HIS D 2 187 ? 20.23124  56.95546  -32.23631 1.000 45.02871  ? 519 HIS D CA  1 
ATOM   3660 C C   . HIS D 2 187 ? 21.72934  57.10802  -32.50071 1.000 43.96314  ? 519 HIS D C   1 
ATOM   3661 O O   . HIS D 2 187 ? 22.38662  58.05837  -32.07224 1.000 43.84021  ? 519 HIS D O   1 
ATOM   3662 C CB  . HIS D 2 187 ? 19.62790  58.23564  -31.67849 1.000 45.37740  ? 519 HIS D CB  1 
ATOM   3663 C CG  . HIS D 2 187 ? 18.13555  58.28944  -31.77040 1.000 47.44690  ? 519 HIS D CG  1 
ATOM   3664 N ND1 . HIS D 2 187 ? 17.40103  59.35977  -31.30684 1.000 49.60645  ? 519 HIS D ND1 1 
ATOM   3665 C CD2 . HIS D 2 187 ? 17.24021  57.41119  -32.28164 1.000 47.49491  ? 519 HIS D CD2 1 
ATOM   3666 C CE1 . HIS D 2 187 ? 16.11717  59.13744  -31.52507 1.000 52.82350  ? 519 HIS D CE1 1 
ATOM   3667 N NE2 . HIS D 2 187 ? 15.99230  57.96265  -32.11686 1.000 53.43227  ? 519 HIS D NE2 1 
ATOM   3668 N N   . ALA D 2 188 ? 22.26401  56.13495  -33.22849 1.000 45.52798  ? 520 ALA D N   1 
ATOM   3669 C CA  . ALA D 2 188 ? 23.69877  55.99649  -33.42854 1.000 44.76986  ? 520 ALA D CA  1 
ATOM   3670 C C   . ALA D 2 188 ? 23.91291  55.11871  -34.65367 1.000 42.83880  ? 520 ALA D C   1 
ATOM   3671 O O   . ALA D 2 188 ? 22.95641  54.51963  -35.16623 1.000 40.56691  ? 520 ALA D O   1 
ATOM   3672 C CB  . ALA D 2 188 ? 24.37588  55.39828  -32.18093 1.000 39.33505  ? 520 ALA D CB  1 
ATOM   3673 N N   . PRO D 2 189 ? 25.14109  55.03729  -35.16971 1.000 41.75791  ? 521 PRO D N   1 
ATOM   3674 C CA  . PRO D 2 189 ? 25.37636  54.18343  -36.34220 1.000 45.78968  ? 521 PRO D CA  1 
ATOM   3675 C C   . PRO D 2 189 ? 25.01376  52.73112  -36.06121 1.000 50.47226  ? 521 PRO D C   1 
ATOM   3676 O O   . PRO D 2 189 ? 25.32121  52.18945  -34.99635 1.000 46.89089  ? 521 PRO D O   1 
ATOM   3677 C CB  . PRO D 2 189 ? 26.87613  54.35008  -36.60884 1.000 41.79299  ? 521 PRO D CB  1 
ATOM   3678 C CG  . PRO D 2 189 ? 27.20603  55.68011  -36.04117 1.000 48.11329  ? 521 PRO D CG  1 
ATOM   3679 C CD  . PRO D 2 189 ? 26.34533  55.81953  -34.82346 1.000 42.15805  ? 521 PRO D CD  1 
ATOM   3680 N N   . ALA D 2 190 ? 24.34747  52.10617  -37.03127 1.000 43.75371  ? 522 ALA D N   1 
ATOM   3681 C CA  . ALA D 2 190 ? 23.95818  50.69831  -36.94841 1.000 52.78369  ? 522 ALA D CA  1 
ATOM   3682 C C   . ALA D 2 190 ? 25.06527  49.86435  -37.58229 1.000 46.37509  ? 522 ALA D C   1 
ATOM   3683 O O   . ALA D 2 190 ? 25.14389  49.74720  -38.80571 1.000 53.74209  ? 522 ALA D O   1 
ATOM   3684 C CB  . ALA D 2 190 ? 22.62004  50.46542  -37.64167 1.000 43.93373  ? 522 ALA D CB  1 
ATOM   3685 N N   . THR D 2 191 ? 25.91735  49.26848  -36.74991 1.000 48.20848  ? 523 THR D N   1 
ATOM   3686 C CA  . THR D 2 191 ? 27.11014  48.57565  -37.21958 1.000 46.35442  ? 523 THR D CA  1 
ATOM   3687 C C   . THR D 2 191 ? 26.96012  47.05871  -37.27626 1.000 50.35046  ? 523 THR D C   1 
ATOM   3688 O O   . THR D 2 191 ? 27.91205  46.37870  -37.66668 1.000 54.69749  ? 523 THR D O   1 
ATOM   3689 C CB  . THR D 2 191 ? 28.30660  48.92588  -36.32904 1.000 51.98463  ? 523 THR D CB  1 
ATOM   3690 O OG1 . THR D 2 191 ? 28.13185  48.33102  -35.03637 1.000 59.60926  ? 523 THR D OG1 1 
ATOM   3691 C CG2 . THR D 2 191 ? 28.43402  50.43056  -36.16911 1.000 55.78572  ? 523 THR D CG2 1 
ATOM   3692 N N   . VAL D 2 192 ? 25.80933  46.50777  -36.89375 1.000 52.63210  ? 524 VAL D N   1 
ATOM   3693 C CA  . VAL D 2 192 ? 25.57483  45.06402  -36.92014 1.000 46.27361  ? 524 VAL D CA  1 
ATOM   3694 C C   . VAL D 2 192 ? 24.40543  44.81086  -37.85337 1.000 43.35143  ? 524 VAL D C   1 
ATOM   3695 O O   . VAL D 2 192 ? 23.25734  45.12417  -37.51564 1.000 49.15627  ? 524 VAL D O   1 
ATOM   3696 C CB  . VAL D 2 192 ? 25.28550  44.48920  -35.52714 1.000 50.36461  ? 524 VAL D CB  1 
ATOM   3697 C CG1 . VAL D 2 192 ? 25.53201  42.98446  -35.51703 1.000 41.50434  ? 524 VAL D CG1 1 
ATOM   3698 C CG2 . VAL D 2 192 ? 26.11202  45.19105  -34.47414 1.000 50.24574  ? 524 VAL D CG2 1 
ATOM   3699 N N   . CYS D 2 193 ? 24.68402  44.22958  -39.01503 1.000 49.12982  ? 525 CYS D N   1 
ATOM   3700 C CA  . CYS D 2 193 ? 23.67267  44.03170  -40.04031 1.000 51.83776  ? 525 CYS D CA  1 
ATOM   3701 C C   . CYS D 2 193 ? 23.51923  42.55510  -40.37871 1.000 56.21345  ? 525 CYS D C   1 
ATOM   3702 O O   . CYS D 2 193 ? 24.47588  41.77799  -40.30652 1.000 56.63335  ? 525 CYS D O   1 
ATOM   3703 C CB  . CYS D 2 193 ? 24.01983  44.81151  -41.31078 1.000 55.57413  ? 525 CYS D CB  1 
ATOM   3704 S SG  . CYS D 2 193 ? 23.96880  46.60232  -41.12384 1.000 63.85574  ? 525 CYS D SG  1 
ATOM   3705 N N   . GLY D 2 194 ? 22.29990  42.17616  -40.74754 1.000 55.37409  ? 526 GLY D N   1 
ATOM   3706 C CA  . GLY D 2 194 ? 22.06608  40.85874  -41.29338 1.000 59.03104  ? 526 GLY D CA  1 
ATOM   3707 C C   . GLY D 2 194 ? 22.69497  40.70742  -42.66530 1.000 59.87989  ? 526 GLY D C   1 
ATOM   3708 O O   . GLY D 2 194 ? 23.02396  41.67618  -43.35033 1.000 62.95451  ? 526 GLY D O   1 
ATOM   3709 N N   . SER D 2 195 ? 22.85761  39.44908  -43.07641 1.000 64.00277  ? 527 SER D N   1 
ATOM   3710 C CA  . SER D 2 195 ? 23.55315  39.13518  -44.32113 1.000 68.94986  ? 527 SER D CA  1 
ATOM   3711 C C   . SER D 2 195 ? 22.75441  39.49584  -45.56813 1.000 66.07880  ? 527 SER D C   1 
ATOM   3712 O O   . SER D 2 195 ? 23.25725  39.28287  -46.67657 1.000 70.19267  ? 527 SER D O   1 
ATOM   3713 C CB  . SER D 2 195 ? 23.92033  37.64830  -44.35485 1.000 60.49682  ? 527 SER D CB  1 
ATOM   3714 O OG  . SER D 2 195 ? 22.76081  36.83312  -44.33150 1.000 63.92315  ? 527 SER D OG  1 
ATOM   3715 N N   . ASN D 2 196 ? 21.54305  40.03822  -45.42869 1.000 62.15930  ? 528 ASN D N   1 
ATOM   3716 C CA  . ASN D 2 196 ? 20.71142  40.38116  -46.57689 1.000 65.39211  ? 528 ASN D CA  1 
ATOM   3717 C C   . ASN D 2 196 ? 20.22419  41.82438  -46.49718 1.000 64.37186  ? 528 ASN D C   1 
ATOM   3718 O O   . ASN D 2 196 ? 19.17145  42.16216  -47.04756 1.000 69.45865  ? 528 ASN D O   1 
ATOM   3719 C CB  . ASN D 2 196 ? 19.52782  39.42017  -46.69569 1.000 65.80069  ? 528 ASN D CB  1 
ATOM   3720 C CG  . ASN D 2 196 ? 18.91875  39.41472  -48.08246 1.000 70.00435  ? 528 ASN D CG  1 
ATOM   3721 O OD1 . ASN D 2 196 ? 19.43437  38.76855  -48.99379 1.000 74.26992  ? 528 ASN D OD1 1 
ATOM   3722 N ND2 . ASN D 2 196 ? 17.81721  40.13892  -48.25024 1.000 64.30601  ? 528 ASN D ND2 1 
ATOM   3723 N N   . SER D 2 197 ? 20.97513  42.68872  -45.81100 1.000 68.77485  ? 529 SER D N   1 
ATOM   3724 C CA  . SER D 2 197 ? 20.59022  44.08912  -45.69094 1.000 69.85316  ? 529 SER D CA  1 
ATOM   3725 C C   . SER D 2 197 ? 21.03814  44.93334  -46.87713 1.000 72.57752  ? 529 SER D C   1 
ATOM   3726 O O   . SER D 2 197 ? 20.64760  46.10352  -46.96020 1.000 73.11280  ? 529 SER D O   1 
ATOM   3727 C CB  . SER D 2 197 ? 21.15703  44.68121  -44.40136 1.000 63.45814  ? 529 SER D CB  1 
ATOM   3728 O OG  . SER D 2 197 ? 22.57556  44.68158  -44.42903 1.000 67.98421  ? 529 SER D OG  1 
ATOM   3729 N N   . GLU D 2 198 ? 21.84345  44.37406  -47.77855 1.000 75.51106  ? 530 GLU D N   1 
ATOM   3730 C CA  . GLU D 2 198 ? 22.29788  45.06641  -48.98381 1.000 84.84879  ? 530 GLU D CA  1 
ATOM   3731 C C   . GLU D 2 198 ? 23.04585  46.35868  -48.65089 1.000 85.77137  ? 530 GLU D C   1 
ATOM   3732 O O   . GLU D 2 198 ? 22.48241  47.45223  -48.71174 1.000 87.46124  ? 530 GLU D O   1 
ATOM   3733 C CB  . GLU D 2 198 ? 21.11065  45.35785  -49.90953 1.000 84.38354  ? 530 GLU D CB  1 
ATOM   3734 C CG  . GLU D 2 198 ? 20.38778  44.10757  -50.39837 1.000 82.06606  ? 530 GLU D CG  1 
ATOM   3735 C CD  . GLU D 2 198 ? 18.97959  44.39818  -50.88333 1.000 85.33504  ? 530 GLU D CD  1 
ATOM   3736 O OE1 . GLU D 2 198 ? 18.41901  45.44156  -50.48811 1.000 93.75126  ? 530 GLU D OE1 1 
ATOM   3737 O OE2 . GLU D 2 198 ? 18.43136  43.58512  -51.65756 1.000 82.77104  ? 530 GLU D OE2 1 
HETATM 3738 C C1  . GOL E 3 .   ? 1.67444   13.85748  14.62523  1.000 61.03564  ? 601 GOL B C1  1 
HETATM 3739 O O1  . GOL E 3 .   ? 0.90627   12.93342  13.88786  1.000 49.96302  ? 601 GOL B O1  1 
HETATM 3740 C C2  . GOL E 3 .   ? 0.82931   14.37738  15.84524  1.000 59.69323  ? 601 GOL B C2  1 
HETATM 3741 O O2  . GOL E 3 .   ? -0.11070  15.33457  15.47189  1.000 64.33770  ? 601 GOL B O2  1 
HETATM 3742 C C3  . GOL E 3 .   ? 1.88204   14.95253  16.84364  1.000 64.83627  ? 601 GOL B C3  1 
HETATM 3743 O O3  . GOL E 3 .   ? 1.26907   15.98655  17.56380  1.000 75.14773  ? 601 GOL B O3  1 
HETATM 3744 C C1  . GOL F 3 .   ? 22.88706  -0.07134  12.23497  1.000 65.53924  ? 602 GOL B C1  1 
HETATM 3745 O O1  . GOL F 3 .   ? 23.38060  0.92285   11.38415  1.000 63.92115  ? 602 GOL B O1  1 
HETATM 3746 C C2  . GOL F 3 .   ? 23.78776  -0.08286  13.49486  1.000 73.27714  ? 602 GOL B C2  1 
HETATM 3747 O O2  . GOL F 3 .   ? 23.66986  1.09145   14.22931  1.000 74.12899  ? 602 GOL B O2  1 
HETATM 3748 C C3  . GOL F 3 .   ? 23.30626  -1.30609  14.29362  1.000 67.60433  ? 602 GOL B C3  1 
HETATM 3749 O O3  . GOL F 3 .   ? 21.92715  -1.16631  14.41831  1.000 68.91098  ? 602 GOL B O3  1 
HETATM 3750 C C1  . GOL G 3 .   ? 26.15998  21.81139  -0.11147  1.000 70.31605  ? 101 GOL C C1  1 
HETATM 3751 O O1  . GOL G 3 .   ? 25.91542  20.49698  0.32402   1.000 60.09253  ? 101 GOL C O1  1 
HETATM 3752 C C2  . GOL G 3 .   ? 24.93145  22.68032  0.30129   1.000 70.07418  ? 101 GOL C C2  1 
HETATM 3753 O O2  . GOL G 3 .   ? 23.87926  22.56008  -0.60986  1.000 53.78037  ? 101 GOL C O2  1 
HETATM 3754 C C3  . GOL G 3 .   ? 25.48206  24.14267  0.39959   1.000 68.15626  ? 101 GOL C C3  1 
HETATM 3755 O O3  . GOL G 3 .   ? 24.43821  24.96459  0.86485   1.000 64.49412  ? 101 GOL C O3  1 
HETATM 3756 C C1  . GOL H 3 .   ? 22.25691  20.67169  -5.08993  1.000 39.08331  ? 102 GOL C C1  1 
HETATM 3757 O O1  . GOL H 3 .   ? 22.87739  19.43392  -4.90493  1.000 41.14554  ? 102 GOL C O1  1 
HETATM 3758 C C2  . GOL H 3 .   ? 22.56145  21.52451  -3.84823  1.000 43.42095  ? 102 GOL C C2  1 
HETATM 3759 O O2  . GOL H 3 .   ? 22.04047  20.98257  -2.68515  1.000 50.93948  ? 102 GOL C O2  1 
HETATM 3760 C C3  . GOL H 3 .   ? 21.94251  22.88242  -4.14860  1.000 42.84091  ? 102 GOL C C3  1 
HETATM 3761 O O3  . GOL H 3 .   ? 22.80919  23.80740  -3.56294  1.000 57.84557  ? 102 GOL C O3  1 
HETATM 3762 C C1  . GOL I 3 .   ? 12.27005  30.25841  -24.85886 1.000 46.82761  ? 601 GOL D C1  1 
HETATM 3763 O O1  . GOL I 3 .   ? 12.44576  31.44403  -24.12954 1.000 42.28932  ? 601 GOL D O1  1 
HETATM 3764 C C2  . GOL I 3 .   ? 12.61208  29.10703  -23.89886 1.000 54.48506  ? 601 GOL D C2  1 
HETATM 3765 O O2  . GOL I 3 .   ? 11.73367  29.05461  -22.81394 1.000 52.53969  ? 601 GOL D O2  1 
HETATM 3766 C C3  . GOL I 3 .   ? 12.58301  27.82485  -24.77517 1.000 49.91995  ? 601 GOL D C3  1 
HETATM 3767 O O3  . GOL I 3 .   ? 13.58395  27.96945  -25.74265 1.000 55.33116  ? 601 GOL D O3  1 
HETATM 3768 C C1  . GOL J 3 .   ? 14.14059  20.28599  -20.56591 1.000 55.96173  ? 602 GOL D C1  1 
HETATM 3769 O O1  . GOL J 3 .   ? 13.12380  19.38395  -20.24517 1.000 65.70397  ? 602 GOL D O1  1 
HETATM 3770 C C2  . GOL J 3 .   ? 13.66936  21.06578  -21.81409 1.000 54.43296  ? 602 GOL D C2  1 
HETATM 3771 O O2  . GOL J 3 .   ? 12.33621  21.44045  -21.71110 1.000 66.84285  ? 602 GOL D O2  1 
HETATM 3772 C C3  . GOL J 3 .   ? 14.61658  22.29177  -21.89000 1.000 52.35243  ? 602 GOL D C3  1 
HETATM 3773 O O3  . GOL J 3 .   ? 14.21643  23.05254  -22.99315 1.000 57.58758  ? 602 GOL D O3  1 
HETATM 3774 C C1  . GOL K 3 .   ? 23.73621  44.75514  -17.94084 1.000 63.02904  ? 603 GOL D C1  1 
HETATM 3775 O O1  . GOL K 3 .   ? 22.76015  45.75215  -18.05757 1.000 71.98718  ? 603 GOL D O1  1 
HETATM 3776 C C2  . GOL K 3 .   ? 24.86218  45.33004  -17.04207 1.000 73.22645  ? 603 GOL D C2  1 
HETATM 3777 O O2  . GOL K 3 .   ? 24.88677  44.73920  -15.78305 1.000 69.64434  ? 603 GOL D O2  1 
HETATM 3778 C C3  . GOL K 3 .   ? 26.18201  45.11636  -17.84078 1.000 78.85725  ? 603 GOL D C3  1 
HETATM 3779 O O3  . GOL K 3 .   ? 26.31246  43.74106  -18.07611 1.000 64.12633  ? 603 GOL D O3  1 
HETATM 3780 C C1  . GOL L 3 .   ? 12.18472  44.00810  -34.12557 1.000 69.89676  ? 604 GOL D C1  1 
HETATM 3781 O O1  . GOL L 3 .   ? 11.08945  43.28366  -33.64175 1.000 68.46984  ? 604 GOL D O1  1 
HETATM 3782 C C2  . GOL L 3 .   ? 13.45216  43.36992  -33.50519 1.000 69.95271  ? 604 GOL D C2  1 
HETATM 3783 O O2  . GOL L 3 .   ? 13.26927  42.01980  -33.22150 1.000 64.76319  ? 604 GOL D O2  1 
HETATM 3784 C C3  . GOL L 3 .   ? 13.74870  44.21787  -32.24258 1.000 67.58435  ? 604 GOL D C3  1 
HETATM 3785 O O3  . GOL L 3 .   ? 14.42966  43.39263  -31.34582 1.000 55.35690  ? 604 GOL D O3  1 
HETATM 3786 C C1  . GOL M 3 .   ? 32.95789  26.60188  -14.45565 1.000 64.13866  ? 605 GOL D C1  1 
HETATM 3787 O O1  . GOL M 3 .   ? 32.72583  25.81268  -15.57951 1.000 67.99700  ? 605 GOL D O1  1 
HETATM 3788 C C2  . GOL M 3 .   ? 31.82034  27.64697  -14.39818 1.000 56.51612  ? 605 GOL D C2  1 
HETATM 3789 O O2  . GOL M 3 .   ? 31.86811  28.52512  -15.47255 1.000 53.74377  ? 605 GOL D O2  1 
HETATM 3790 C C3  . GOL M 3 .   ? 31.99884  28.37898  -13.03456 1.000 64.38519  ? 605 GOL D C3  1 
HETATM 3791 O O3  . GOL M 3 .   ? 31.09506  29.45861  -13.03592 1.000 55.04629  ? 605 GOL D O3  1 
HETATM 3792 O O   . HOH N 4 .   ? 3.32037   12.76515  18.66165  1.000 52.18893  ? 101 HOH A O   1 
HETATM 3793 O O   . HOH N 4 .   ? 4.38410   20.06953  -4.94246  1.000 54.23057  ? 102 HOH A O   1 
HETATM 3794 O O   . HOH N 4 .   ? 1.79798   8.73482   4.02964   1.000 38.15191  ? 103 HOH A O   1 
HETATM 3795 O O   . HOH N 4 .   ? 10.27683  17.95812  16.56418  1.000 59.41278  ? 104 HOH A O   1 
HETATM 3796 O O   . HOH N 4 .   ? 10.91321  12.47805  19.14747  1.000 46.86676  ? 105 HOH A O   1 
HETATM 3797 O O   . HOH N 4 .   ? 5.20209   7.31355   -4.19739  1.000 51.16177  ? 106 HOH A O   1 
HETATM 3798 O O   . HOH N 4 .   ? -1.22880  14.69650  -0.99712  1.000 46.91758  ? 107 HOH A O   1 
HETATM 3799 O O   . HOH N 4 .   ? 14.49131  16.53747  10.01735  1.000 55.81857  ? 108 HOH A O   1 
HETATM 3800 O O   . HOH N 4 .   ? 10.27780  8.39312   8.89428   1.000 45.07896  ? 109 HOH A O   1 
HETATM 3801 O O   . HOH N 4 .   ? 13.96867  7.20621   10.72240  1.000 45.64455  ? 110 HOH A O   1 
HETATM 3802 O O   . HOH N 4 .   ? 8.44313   18.43380  -6.42808  1.000 53.35303  ? 111 HOH A O   1 
HETATM 3803 O O   . HOH N 4 .   ? -1.68969  9.96952   1.36646   1.000 36.77561  ? 112 HOH A O   1 
HETATM 3804 O O   . HOH N 4 .   ? 3.98096   14.59420  -5.24992  1.000 40.90899  ? 113 HOH A O   1 
HETATM 3805 O O   . HOH N 4 .   ? 8.72269   6.75834   1.19858   1.000 38.55149  ? 114 HOH A O   1 
HETATM 3806 O O   . HOH N 4 .   ? 5.18276   13.38416  14.24704  1.000 44.40084  ? 115 HOH A O   1 
HETATM 3807 O O   . HOH N 4 .   ? 2.83981   7.28859   -5.40194  1.000 49.77665  ? 116 HOH A O   1 
HETATM 3808 O O   . HOH N 4 .   ? -1.56739  17.03156  -4.31595  1.000 57.79450  ? 117 HOH A O   1 
HETATM 3809 O O   . HOH N 4 .   ? 10.48692  4.67867   -0.79476  1.000 53.83609  ? 118 HOH A O   1 
HETATM 3810 O O   . HOH N 4 .   ? 17.27603  8.08652   -3.03354  1.000 46.21657  ? 119 HOH A O   1 
HETATM 3811 O O   . HOH N 4 .   ? 16.22814  14.09276  7.30965   1.000 50.31704  ? 120 HOH A O   1 
HETATM 3812 O O   . HOH N 4 .   ? 17.29287  5.36454   -3.36999  1.000 48.48803  ? 121 HOH A O   1 
HETATM 3813 O O   . HOH N 4 .   ? 11.98246  10.21475  12.02047  1.000 48.88310  ? 122 HOH A O   1 
HETATM 3814 O O   . HOH N 4 .   ? 23.54427  5.77149   -0.05441  1.000 50.51540  ? 123 HOH A O   1 
HETATM 3815 O O   . HOH N 4 .   ? 6.48349   20.45541  -3.18350  1.000 49.50836  ? 124 HOH A O   1 
HETATM 3816 O O   . HOH N 4 .   ? 13.53603  12.35081  12.40878  1.000 45.58681  ? 125 HOH A O   1 
HETATM 3817 O O   . HOH N 4 .   ? 19.31434  8.96768   -5.60328  1.000 52.39357  ? 126 HOH A O   1 
HETATM 3818 O O   . HOH N 4 .   ? 15.34810  10.78381  12.28678  1.000 55.80961  ? 127 HOH A O   1 
HETATM 3819 O O   . HOH N 4 .   ? 0.44723   13.41079  -2.49136  1.000 43.94648  ? 128 HOH A O   1 
HETATM 3820 O O   . HOH N 4 .   ? -2.20732  23.10588  0.14854   1.000 45.21294  ? 129 HOH A O   1 
HETATM 3821 O O   . HOH N 4 .   ? 1.47913   13.95374  -4.96770  1.000 48.21790  ? 130 HOH A O   1 
HETATM 3822 O O   . HOH N 4 .   ? -0.17765  11.03690  -2.78427  1.000 46.50489  ? 131 HOH A O   1 
HETATM 3823 O O   . HOH O 4 .   ? 13.94146  1.80075   -7.53378  1.000 45.93454  ? 701 HOH B O   1 
HETATM 3824 O O   . HOH O 4 .   ? 11.17695  -5.97128  30.90653  1.000 48.04902  ? 702 HOH B O   1 
HETATM 3825 O O   . HOH O 4 .   ? 9.96954   3.70584   27.12884  1.000 45.74978  ? 703 HOH B O   1 
HETATM 3826 O O   . HOH O 4 .   ? 19.87358  5.01851   15.59502  1.000 32.87104  ? 704 HOH B O   1 
HETATM 3827 O O   . HOH O 4 .   ? 1.43314   1.86556   14.33898  1.000 31.76061  ? 705 HOH B O   1 
HETATM 3828 O O   . HOH O 4 .   ? -0.83843  15.33067  18.67892  1.000 63.45304  ? 706 HOH B O   1 
HETATM 3829 O O   . HOH O 4 .   ? 2.80271   7.48819   0.02750   1.000 48.69182  ? 707 HOH B O   1 
HETATM 3830 O O   . HOH O 4 .   ? 10.02195  -14.07998 13.84255  1.000 46.75713  ? 708 HOH B O   1 
HETATM 3831 O O   . HOH O 4 .   ? 7.54948   -12.54102 16.87608  1.000 50.69646  ? 709 HOH B O   1 
HETATM 3832 O O   . HOH O 4 .   ? -8.17534  4.16282   4.56352   1.000 48.36598  ? 710 HOH B O   1 
HETATM 3833 O O   . HOH O 4 .   ? 8.94775   -10.89331 5.18339   1.000 46.35230  ? 711 HOH B O   1 
HETATM 3834 O O   . HOH O 4 .   ? 19.30893  3.25557   21.86381  1.000 41.58628  ? 712 HOH B O   1 
HETATM 3835 O O   . HOH O 4 .   ? 7.59235   -11.26067 12.50918  1.000 48.35295  ? 713 HOH B O   1 
HETATM 3836 O O   . HOH O 4 .   ? 25.19144  -3.57112  11.10150  1.000 53.39653  ? 714 HOH B O   1 
HETATM 3837 O O   . HOH O 4 .   ? -12.25351 14.69680  12.02553  1.000 42.22893  ? 715 HOH B O   1 
HETATM 3838 O O   . HOH O 4 .   ? -4.30946  -3.13765  8.76765   1.000 54.56274  ? 716 HOH B O   1 
HETATM 3839 O O   . HOH O 4 .   ? 10.99487  3.22328   24.23966  1.000 44.64469  ? 717 HOH B O   1 
HETATM 3840 O O   . HOH O 4 .   ? -6.46002  21.65974  4.20552   1.000 49.91917  ? 718 HOH B O   1 
HETATM 3841 O O   . HOH O 4 .   ? -1.92422  5.16007   22.97292  1.000 45.54765  ? 719 HOH B O   1 
HETATM 3842 O O   . HOH O 4 .   ? 3.97696   -6.33786  6.06464   1.000 47.32695  ? 720 HOH B O   1 
HETATM 3843 O O   . HOH O 4 .   ? 15.17578  8.89454   22.06607  1.000 46.93481  ? 721 HOH B O   1 
HETATM 3844 O O   . HOH O 4 .   ? 24.82077  -4.54017  4.42887   1.000 54.45921  ? 722 HOH B O   1 
HETATM 3845 O O   . HOH O 4 .   ? 2.16898   -7.95725  4.10916   1.000 50.40756  ? 723 HOH B O   1 
HETATM 3846 O O   . HOH O 4 .   ? -5.28451  4.88070   11.25116  1.000 46.52010  ? 724 HOH B O   1 
HETATM 3847 O O   . HOH O 4 .   ? 1.26818   -11.21889 16.79128  1.000 50.41406  ? 725 HOH B O   1 
HETATM 3848 O O   . HOH O 4 .   ? -8.88079  8.15559   16.53508  1.000 70.87388  ? 726 HOH B O   1 
HETATM 3849 O O   . HOH O 4 .   ? 3.258     -7.106    0.717     1.000 40.68704  ? 727 HOH B O   1 
HETATM 3850 O O   . HOH O 4 .   ? 4.47953   -1.25161  21.12165  1.000 37.75318  ? 728 HOH B O   1 
HETATM 3851 O O   . HOH O 4 .   ? 8.08968   -17.24911 7.64327   1.000 60.83710  ? 729 HOH B O   1 
HETATM 3852 O O   . HOH O 4 .   ? -2.66796  6.64161   12.27288  1.000 28.55809  ? 730 HOH B O   1 
HETATM 3853 O O   . HOH O 4 .   ? -11.61843 13.23440  8.24060   1.000 45.19292  ? 731 HOH B O   1 
HETATM 3854 O O   . HOH O 4 .   ? -7.20698  7.34868   -0.60383  1.000 49.88419  ? 732 HOH B O   1 
HETATM 3855 O O   . HOH O 4 .   ? 16.30279  6.68544   15.11989  1.000 41.85932  ? 733 HOH B O   1 
HETATM 3856 O O   . HOH O 4 .   ? 3.75100   12.75539  11.98237  1.000 43.22899  ? 734 HOH B O   1 
HETATM 3857 O O   . HOH O 4 .   ? 14.89184  -0.29303  31.69363  1.000 42.94487  ? 735 HOH B O   1 
HETATM 3858 O O   . HOH O 4 .   ? 18.15841  -2.17539  22.17499  1.000 43.15415  ? 736 HOH B O   1 
HETATM 3859 O O   . HOH O 4 .   ? 15.21771  -14.47005 9.75427   1.000 57.73785  ? 737 HOH B O   1 
HETATM 3860 O O   . HOH O 4 .   ? -10.20917 10.75357  8.51361   1.000 45.28712  ? 738 HOH B O   1 
HETATM 3861 O O   . HOH O 4 .   ? -6.76858  9.38074   -2.81529  1.000 57.90866  ? 739 HOH B O   1 
HETATM 3862 O O   . HOH O 4 .   ? -1.52412  18.87126  11.31520  1.000 49.22757  ? 740 HOH B O   1 
HETATM 3863 O O   . HOH O 4 .   ? -4.05346  5.62440   14.38619  1.000 35.49652  ? 741 HOH B O   1 
HETATM 3864 O O   . HOH O 4 .   ? 1.80319   -0.51930  15.95144  1.000 36.32055  ? 742 HOH B O   1 
HETATM 3865 O O   . HOH O 4 .   ? 7.47374   7.10463   22.80312  1.000 34.14313  ? 743 HOH B O   1 
HETATM 3866 O O   . HOH O 4 .   ? -4.89407  7.72802   11.01122  1.000 33.26894  ? 744 HOH B O   1 
HETATM 3867 O O   . HOH O 4 .   ? 2.50931   -3.84438  4.99265   1.000 41.89837  ? 745 HOH B O   1 
HETATM 3868 O O   . HOH O 4 .   ? -3.80655  6.92883   23.12976  1.000 46.19956  ? 746 HOH B O   1 
HETATM 3869 O O   . HOH O 4 .   ? 8.69022   -8.85918  23.81641  1.000 46.30000  ? 747 HOH B O   1 
HETATM 3870 O O   . HOH O 4 .   ? 5.25344   5.68839   22.26811  1.000 36.04191  ? 748 HOH B O   1 
HETATM 3871 O O   . HOH O 4 .   ? -4.68005  3.32851   23.84852  1.000 43.93152  ? 749 HOH B O   1 
HETATM 3872 O O   . HOH O 4 .   ? -2.83916  22.99869  2.53226   1.000 51.82177  ? 750 HOH B O   1 
HETATM 3873 O O   . HOH O 4 .   ? 18.39221  8.51236   12.89068  1.000 50.54892  ? 751 HOH B O   1 
HETATM 3874 O O   . HOH O 4 .   ? -5.86919  14.55615  13.24763  1.000 54.49876  ? 752 HOH B O   1 
HETATM 3875 O O   . HOH O 4 .   ? 10.62502  1.36642   21.53775  1.000 34.72231  ? 753 HOH B O   1 
HETATM 3876 O O   . HOH O 4 .   ? 11.06667  5.68300   8.40495   1.000 44.53611  ? 754 HOH B O   1 
HETATM 3877 O O   . HOH O 4 .   ? 1.24001   -0.70170  28.49992  1.000 43.62622  ? 755 HOH B O   1 
HETATM 3878 O O   . HOH O 4 .   ? 4.45651   5.46416   26.06740  1.000 41.97049  ? 756 HOH B O   1 
HETATM 3879 O O   . HOH O 4 .   ? 3.28204   -7.33639  8.56920   1.000 46.02630  ? 757 HOH B O   1 
HETATM 3880 O O   . HOH O 4 .   ? 19.92299  2.83575   15.36551  1.000 40.34915  ? 758 HOH B O   1 
HETATM 3881 O O   . HOH O 4 .   ? 17.05336  6.29678   19.49444  1.000 52.56046  ? 759 HOH B O   1 
HETATM 3882 O O   . HOH O 4 .   ? 25.95584  -2.16447  1.83860   1.000 55.16725  ? 760 HOH B O   1 
HETATM 3883 O O   . HOH O 4 .   ? 8.17628   -2.53666  8.53345   1.000 38.11702  ? 761 HOH B O   1 
HETATM 3884 O O   . HOH O 4 .   ? 5.48145   -8.67774  6.25273   1.000 44.23656  ? 762 HOH B O   1 
HETATM 3885 O O   . HOH O 4 .   ? -10.36466 5.24734   4.14812   1.000 58.68783  ? 763 HOH B O   1 
HETATM 3886 O O   . HOH O 4 .   ? 7.96599   -13.61972 11.89882  1.000 46.81009  ? 764 HOH B O   1 
HETATM 3887 O O   . HOH O 4 .   ? 6.12065   -11.06592 4.45160   1.000 50.89142  ? 765 HOH B O   1 
HETATM 3888 O O   . HOH O 4 .   ? 5.62101   -2.31364  34.63973  1.000 57.08763  ? 766 HOH B O   1 
HETATM 3889 O O   . HOH O 4 .   ? -11.48613 9.59111   6.55333   1.000 55.20091  ? 767 HOH B O   1 
HETATM 3890 O O   . HOH O 4 .   ? 15.62637  -7.93829  -6.27699  1.000 43.67721  ? 768 HOH B O   1 
HETATM 3891 O O   . HOH O 4 .   ? -7.58338  17.77764  6.53370   1.000 43.13812  ? 769 HOH B O   1 
HETATM 3892 O O   . HOH O 4 .   ? 4.38490   4.14505   0.79009   1.000 41.86943  ? 770 HOH B O   1 
HETATM 3893 O O   . HOH O 4 .   ? -2.42495  12.49674  0.40654   1.000 41.14060  ? 771 HOH B O   1 
HETATM 3894 O O   . HOH O 4 .   ? -4.40114  4.94167   21.21557  1.000 51.85761  ? 772 HOH B O   1 
HETATM 3895 O O   . HOH O 4 .   ? -0.50515  -8.50025  21.17257  1.000 59.60756  ? 773 HOH B O   1 
HETATM 3896 O O   . HOH O 4 .   ? 16.70943  -0.49649  -7.05473  1.000 43.70514  ? 774 HOH B O   1 
HETATM 3897 O O   . HOH O 4 .   ? -7.64528  13.00721  -3.85096  1.000 51.08960  ? 775 HOH B O   1 
HETATM 3898 O O   . HOH O 4 .   ? 11.14659  -10.35874 2.61375   1.000 49.47677  ? 776 HOH B O   1 
HETATM 3899 O O   . HOH O 4 .   ? 6.09562   -22.36839 23.05595  1.000 66.76423  ? 777 HOH B O   1 
HETATM 3900 O O   . HOH O 4 .   ? 7.95519   -4.80330  -3.66093  1.000 43.24636  ? 778 HOH B O   1 
HETATM 3901 O O   . HOH O 4 .   ? -14.12222 12.59469  6.99511   1.000 54.17847  ? 779 HOH B O   1 
HETATM 3902 O O   . HOH O 4 .   ? -3.17841  -0.96120  2.86503   1.000 48.83879  ? 780 HOH B O   1 
HETATM 3903 O O   . HOH O 4 .   ? 19.93274  1.66477   24.91643  1.000 53.93227  ? 781 HOH B O   1 
HETATM 3904 O O   . HOH O 4 .   ? 1.74206   -9.13066  11.20699  1.000 50.72899  ? 782 HOH B O   1 
HETATM 3905 O O   . HOH O 4 .   ? 7.161     -7.739    -1.314    1.000 52.72621  ? 783 HOH B O   1 
HETATM 3906 O O   . HOH O 4 .   ? 12.53977  9.36120   14.33704  1.000 38.94260  ? 784 HOH B O   1 
HETATM 3907 O O   . HOH O 4 .   ? 9.13491   -8.72720  1.93147   1.000 48.04743  ? 785 HOH B O   1 
HETATM 3908 O O   . HOH O 4 .   ? -2.65551  -3.12543  21.32373  1.000 43.50162  ? 786 HOH B O   1 
HETATM 3909 O O   . HOH O 4 .   ? -7.75833  22.82767  6.77550   1.000 58.95513  ? 787 HOH B O   1 
HETATM 3910 O O   . HOH O 4 .   ? 0.64587   1.83316   1.99073   1.000 48.93582  ? 788 HOH B O   1 
HETATM 3911 O O   . HOH O 4 .   ? 9.44417   7.78437   26.58003  1.000 52.12322  ? 789 HOH B O   1 
HETATM 3912 O O   . HOH O 4 .   ? -7.32282  16.76641  -2.27824  1.000 50.51495  ? 790 HOH B O   1 
HETATM 3913 O O   . HOH O 4 .   ? -10.44901 6.71843   6.49957   1.000 42.53530  ? 791 HOH B O   1 
HETATM 3914 O O   . HOH O 4 .   ? 11.68593  -8.47734  30.34686  1.000 58.14983  ? 792 HOH B O   1 
HETATM 3915 O O   . HOH O 4 .   ? 20.24577  -11.73487 -2.08710  1.000 61.19024  ? 793 HOH B O   1 
HETATM 3916 O O   . HOH O 4 .   ? -6.63716  18.01583  12.69184  1.000 51.61845  ? 794 HOH B O   1 
HETATM 3917 O O   . HOH O 4 .   ? -7.05804  5.39596   13.65546  1.000 55.16910  ? 795 HOH B O   1 
HETATM 3918 O O   . HOH O 4 .   ? -7.25271  11.79737  11.91658  1.000 39.87250  ? 796 HOH B O   1 
HETATM 3919 O O   . HOH O 4 .   ? 14.12538  4.28195   30.62688  1.000 46.20259  ? 797 HOH B O   1 
HETATM 3920 O O   . HOH O 4 .   ? 21.95825  1.53495   16.85588  1.000 53.68681  ? 798 HOH B O   1 
HETATM 3921 O O   . HOH O 4 .   ? 14.64753  8.16187   13.14431  1.000 39.85955  ? 799 HOH B O   1 
HETATM 3922 O O   . HOH O 4 .   ? 24.76047  -0.55009  -0.54364  1.000 60.94549  ? 800 HOH B O   1 
HETATM 3923 O O   . HOH O 4 .   ? 0.05318   -13.53384 6.17447   1.000 56.03850  ? 801 HOH B O   1 
HETATM 3924 O O   . HOH O 4 .   ? -5.54068  -1.32819  15.83630  1.000 47.01823  ? 802 HOH B O   1 
HETATM 3925 O O   . HOH O 4 .   ? 22.99451  5.43063   5.47639   1.000 53.11864  ? 803 HOH B O   1 
HETATM 3926 O O   . HOH O 4 .   ? 19.63289  7.42135   15.51683  1.000 52.84920  ? 804 HOH B O   1 
HETATM 3927 O O   . HOH O 4 .   ? -4.79079  7.96246   15.76762  1.000 50.89911  ? 805 HOH B O   1 
HETATM 3928 O O   . HOH O 4 .   ? 4.78268   7.08399   -1.34740  1.000 45.20993  ? 806 HOH B O   1 
HETATM 3929 O O   . HOH O 4 .   ? -1.02213  -6.19966  22.03682  1.000 61.42392  ? 807 HOH B O   1 
HETATM 3930 O O   . HOH O 4 .   ? 22.05864  5.26729   17.07352  1.000 50.81779  ? 808 HOH B O   1 
HETATM 3931 O O   . HOH O 4 .   ? 4.707     -6.155    -1.453    1.000 38.46484  ? 809 HOH B O   1 
HETATM 3932 O O   . HOH O 4 .   ? 13.46500  6.61372   30.94850  1.000 50.17573  ? 810 HOH B O   1 
HETATM 3933 O O   . HOH O 4 .   ? -14.916   17.972    1.967     1.000 62.36291  ? 811 HOH B O   1 
HETATM 3934 O O   . HOH O 4 .   ? 21.65361  5.62835   13.97118  1.000 48.20309  ? 812 HOH B O   1 
HETATM 3935 O O   . HOH O 4 .   ? -9.31001  14.54066  -1.90880  1.000 59.03744  ? 813 HOH B O   1 
HETATM 3936 O O   . HOH O 4 .   ? 17.21875  8.30367   17.06214  1.000 46.44685  ? 814 HOH B O   1 
HETATM 3937 O O   . HOH O 4 .   ? -2.94764  11.84911  -2.37747  1.000 49.78756  ? 815 HOH B O   1 
HETATM 3938 O O   . HOH O 4 .   ? -6.59814  9.42663   12.38457  1.000 44.49262  ? 816 HOH B O   1 
HETATM 3939 O O   . HOH O 4 .   ? 10.19327  -12.44267 2.58380   1.000 58.61708  ? 817 HOH B O   1 
HETATM 3940 O O   . HOH O 4 .   ? -2.91772  14.91009  -3.19283  1.000 53.57272  ? 818 HOH B O   1 
HETATM 3941 O O   . HOH O 4 .   ? 1.194     -4.964    1.958     1.000 49.71994  ? 819 HOH B O   1 
HETATM 3942 O O   . HOH O 4 .   ? 2.31632   0.40588   0.35336   1.000 51.48357  ? 820 HOH B O   1 
HETATM 3943 O O   . HOH O 4 .   ? -2.10167  7.88961   -0.43373  1.000 41.97422  ? 821 HOH B O   1 
HETATM 3944 O O   . HOH P 4 .   ? 23.29015  28.38912  1.01638   1.000 52.00228  ? 201 HOH C O   1 
HETATM 3945 O O   . HOH P 4 .   ? 21.37663  8.62505   2.68873   1.000 46.10079  ? 202 HOH C O   1 
HETATM 3946 O O   . HOH P 4 .   ? 10.94890  21.27940  -8.17879  1.000 50.85813  ? 203 HOH C O   1 
HETATM 3947 O O   . HOH P 4 .   ? 14.20918  25.11567  -10.36262 1.000 35.69148  ? 204 HOH C O   1 
HETATM 3948 O O   . HOH P 4 .   ? 16.05978  26.05132  -6.83815  1.000 30.51909  ? 205 HOH C O   1 
HETATM 3949 O O   . HOH P 4 .   ? 7.21434   32.53233  -8.64298  1.000 58.49538  ? 206 HOH C O   1 
HETATM 3950 O O   . HOH P 4 .   ? 17.40520  19.08526  10.54684  1.000 51.71388  ? 207 HOH C O   1 
HETATM 3951 O O   . HOH P 4 .   ? 20.66733  9.96198   6.61866   1.000 59.11821  ? 208 HOH C O   1 
HETATM 3952 O O   . HOH P 4 .   ? 23.85964  7.94142   -1.67222  1.000 53.74937  ? 209 HOH C O   1 
HETATM 3953 O O   . HOH P 4 .   ? 9.99579   20.78710  -5.30186  1.000 38.39726  ? 210 HOH C O   1 
HETATM 3954 O O   . HOH P 4 .   ? 23.64364  13.42007  -6.24874  1.000 46.60957  ? 211 HOH C O   1 
HETATM 3955 O O   . HOH P 4 .   ? 25.43639  14.54026  -4.05505  1.000 54.45616  ? 212 HOH C O   1 
HETATM 3956 O O   . HOH P 4 .   ? 22.25985  26.61037  8.61504   1.000 50.99190  ? 213 HOH C O   1 
HETATM 3957 O O   . HOH P 4 .   ? 5.06006   30.95271  -3.65211  1.000 56.60020  ? 214 HOH C O   1 
HETATM 3958 O O   . HOH P 4 .   ? 16.95860  10.50551  -12.11290 1.000 45.93875  ? 215 HOH C O   1 
HETATM 3959 O O   . HOH P 4 .   ? 18.20970  12.44746  -5.33084  1.000 40.93026  ? 216 HOH C O   1 
HETATM 3960 O O   . HOH P 4 .   ? 20.24168  12.53922  -7.19891  1.000 46.46282  ? 217 HOH C O   1 
HETATM 3961 O O   . HOH P 4 .   ? 25.04905  13.86957  6.36135   1.000 56.83479  ? 218 HOH C O   1 
HETATM 3962 O O   . HOH P 4 .   ? 12.24786  27.21984  -7.84299  1.000 45.70143  ? 219 HOH C O   1 
HETATM 3963 O O   . HOH P 4 .   ? 22.57055  19.75071  7.34006   1.000 50.44613  ? 220 HOH C O   1 
HETATM 3964 O O   . HOH P 4 .   ? 20.30306  20.35125  13.67389  1.000 57.15710  ? 221 HOH C O   1 
HETATM 3965 O O   . HOH P 4 .   ? 9.70386   26.63498  -7.37987  1.000 51.75861  ? 222 HOH C O   1 
HETATM 3966 O O   . HOH P 4 .   ? 18.06213  16.16154  8.00523   1.000 47.27873  ? 223 HOH C O   1 
HETATM 3967 O O   . HOH P 4 .   ? 8.08506   22.14512  -4.17465  1.000 51.24396  ? 224 HOH C O   1 
HETATM 3968 O O   . HOH P 4 .   ? 6.44045   30.89235  -6.50179  1.000 60.27099  ? 225 HOH C O   1 
HETATM 3969 O O   . HOH Q 4 .   ? 32.45152  23.45427  -15.43596 1.000 50.37184  ? 701 HOH D O   1 
HETATM 3970 O O   . HOH Q 4 .   ? 20.67311  36.80536  -48.47219 1.000 69.57050  ? 702 HOH D O   1 
HETATM 3971 O O   . HOH Q 4 .   ? 27.16037  52.72508  -33.55383 1.000 53.11061  ? 703 HOH D O   1 
HETATM 3972 O O   . HOH Q 4 .   ? 10.13526  24.44977  -17.14286 1.000 29.81940  ? 704 HOH D O   1 
HETATM 3973 O O   . HOH Q 4 .   ? 9.48579   39.84647  -17.77453 1.000 56.05104  ? 705 HOH D O   1 
HETATM 3974 O O   . HOH Q 4 .   ? 12.63517  37.62058  -2.06374  1.000 50.97311  ? 706 HOH D O   1 
HETATM 3975 O O   . HOH Q 4 .   ? 29.21085  28.66193  -3.10658  1.000 56.79987  ? 707 HOH D O   1 
HETATM 3976 O O   . HOH Q 4 .   ? 21.52822  40.19631  -3.29627  1.000 43.51802  ? 708 HOH D O   1 
HETATM 3977 O O   . HOH Q 4 .   ? 11.81830  43.13144  -12.08439 1.000 56.27136  ? 709 HOH D O   1 
HETATM 3978 O O   . HOH Q 4 .   ? 19.52436  19.79537  -26.83648 1.000 51.37486  ? 710 HOH D O   1 
HETATM 3979 O O   . HOH Q 4 .   ? 28.98256  32.46822  -20.76223 1.000 42.61722  ? 711 HOH D O   1 
HETATM 3980 O O   . HOH Q 4 .   ? 13.21570  24.55524  -24.71404 1.000 57.85232  ? 712 HOH D O   1 
HETATM 3981 O O   . HOH Q 4 .   ? 7.72579   40.51213  -25.08092 1.000 54.47034  ? 713 HOH D O   1 
HETATM 3982 O O   . HOH Q 4 .   ? 30.69333  34.93618  -15.01512 1.000 44.35215  ? 714 HOH D O   1 
HETATM 3983 O O   . HOH Q 4 .   ? 29.12428  25.21311  -26.10567 1.000 48.62962  ? 715 HOH D O   1 
HETATM 3984 O O   . HOH Q 4 .   ? 22.84927  18.28940  -7.42038  1.000 37.46603  ? 716 HOH D O   1 
HETATM 3985 O O   . HOH Q 4 .   ? 8.27507   30.04768  -20.76862 1.000 48.28608  ? 717 HOH D O   1 
HETATM 3986 O O   . HOH Q 4 .   ? 21.96920  36.82408  -8.84122  1.000 36.58570  ? 718 HOH D O   1 
HETATM 3987 O O   . HOH Q 4 .   ? 21.57005  52.23851  -35.00689 1.000 52.50947  ? 719 HOH D O   1 
HETATM 3988 O O   . HOH Q 4 .   ? 11.16760  37.06341  -17.43965 1.000 43.02965  ? 720 HOH D O   1 
HETATM 3989 O O   . HOH Q 4 .   ? 28.39328  26.25039  -3.25699  1.000 48.98696  ? 721 HOH D O   1 
HETATM 3990 O O   . HOH Q 4 .   ? 22.77556  19.27997  -27.00948 1.000 49.32500  ? 722 HOH D O   1 
HETATM 3991 O O   . HOH Q 4 .   ? 24.50661  39.02420  -1.66806  1.000 56.71646  ? 723 HOH D O   1 
HETATM 3992 O O   . HOH Q 4 .   ? 12.99201  38.28125  -32.27538 1.000 49.94408  ? 724 HOH D O   1 
HETATM 3993 O O   . HOH Q 4 .   ? 8.54792   28.73395  -16.40481 1.000 46.56564  ? 725 HOH D O   1 
HETATM 3994 O O   . HOH Q 4 .   ? 11.09245  26.52621  -13.86591 1.000 35.12896  ? 726 HOH D O   1 
HETATM 3995 O O   . HOH Q 4 .   ? 20.90731  39.72411  -24.45987 1.000 41.13941  ? 727 HOH D O   1 
HETATM 3996 O O   . HOH Q 4 .   ? 30.03894  36.03616  2.48410   1.000 58.85251  ? 728 HOH D O   1 
HETATM 3997 O O   . HOH Q 4 .   ? 25.92452  16.04244  -6.94558  1.000 41.44869  ? 729 HOH D O   1 
HETATM 3998 O O   . HOH Q 4 .   ? 10.51942  38.16290  -12.17059 1.000 48.35887  ? 730 HOH D O   1 
HETATM 3999 O O   . HOH Q 4 .   ? 11.84881  19.76927  -17.92491 1.000 53.19372  ? 731 HOH D O   1 
HETATM 4000 O O   . HOH Q 4 .   ? 11.99406  24.51874  -18.79488 1.000 36.13268  ? 732 HOH D O   1 
HETATM 4001 O O   . HOH Q 4 .   ? 13.02299  39.56482  -11.64767 1.000 43.14491  ? 733 HOH D O   1 
HETATM 4002 O O   . HOH Q 4 .   ? 35.30301  28.78126  -23.16788 1.000 63.32244  ? 734 HOH D O   1 
HETATM 4003 O O   . HOH Q 4 .   ? 16.52075  18.58602  -24.64298 1.000 40.60167  ? 735 HOH D O   1 
HETATM 4004 O O   . HOH Q 4 .   ? 25.80911  27.13273  -0.88104  1.000 50.54234  ? 736 HOH D O   1 
HETATM 4005 O O   . HOH Q 4 .   ? 13.97012  35.66330  -17.24373 1.000 38.87035  ? 737 HOH D O   1 
HETATM 4006 O O   . HOH Q 4 .   ? 21.41475  37.69031  -2.19610  1.000 41.96167  ? 738 HOH D O   1 
HETATM 4007 O O   . HOH Q 4 .   ? 27.90558  35.78307  -23.47923 1.000 38.75693  ? 739 HOH D O   1 
HETATM 4008 O O   . HOH Q 4 .   ? 14.20068  43.12125  -26.95902 1.000 50.99117  ? 740 HOH D O   1 
HETATM 4009 O O   . HOH Q 4 .   ? 5.88674   32.34959  -14.79626 1.000 55.66934  ? 741 HOH D O   1 
HETATM 4010 O O   . HOH Q 4 .   ? 29.16995  31.98707  -24.45806 1.000 42.75658  ? 742 HOH D O   1 
HETATM 4011 O O   . HOH Q 4 .   ? 23.95837  45.17465  -13.23459 1.000 59.96633  ? 743 HOH D O   1 
HETATM 4012 O O   . HOH Q 4 .   ? 26.36726  9.98591   -12.63255 1.000 51.58280  ? 744 HOH D O   1 
HETATM 4013 O O   . HOH Q 4 .   ? 24.51979  29.28938  4.60456   1.000 44.10685  ? 745 HOH D O   1 
HETATM 4014 O O   . HOH Q 4 .   ? 28.23279  10.86169  -10.25666 1.000 50.67852  ? 746 HOH D O   1 
HETATM 4015 O O   . HOH Q 4 .   ? 23.23276  40.41214  6.11297   1.000 56.94245  ? 747 HOH D O   1 
HETATM 4016 O O   . HOH Q 4 .   ? 22.36352  38.07949  0.36723   1.000 49.71968  ? 748 HOH D O   1 
HETATM 4017 O O   . HOH Q 4 .   ? 22.43041  37.96202  -11.34179 1.000 39.21814  ? 749 HOH D O   1 
HETATM 4018 O O   . HOH Q 4 .   ? 30.95954  31.69098  -11.38866 1.000 52.14563  ? 750 HOH D O   1 
HETATM 4019 O O   . HOH Q 4 .   ? 18.02742  25.47174  -8.90843  1.000 35.77831  ? 751 HOH D O   1 
HETATM 4020 O O   . HOH Q 4 .   ? 24.89357  28.29729  -13.28054 1.000 31.48988  ? 752 HOH D O   1 
HETATM 4021 O O   . HOH Q 4 .   ? 19.14762  39.84809  -15.91635 1.000 42.69898  ? 753 HOH D O   1 
HETATM 4022 O O   . HOH Q 4 .   ? 14.32099  32.42228  -1.37244  1.000 36.73900  ? 754 HOH D O   1 
HETATM 4023 O O   . HOH Q 4 .   ? 31.07305  31.53318  -22.49321 1.000 46.29144  ? 755 HOH D O   1 
HETATM 4024 O O   . HOH Q 4 .   ? 12.31097  33.12431  -2.54226  1.000 43.85262  ? 756 HOH D O   1 
HETATM 4025 O O   . HOH Q 4 .   ? 13.64348  19.81766  -12.61554 1.000 55.27718  ? 757 HOH D O   1 
HETATM 4026 O O   . HOH Q 4 .   ? 7.90073   36.83564  -8.14266  1.000 51.76366  ? 758 HOH D O   1 
HETATM 4027 O O   . HOH Q 4 .   ? 19.60202  10.35569  -17.00101 1.000 45.11355  ? 759 HOH D O   1 
HETATM 4028 O O   . HOH Q 4 .   ? 9.67323   44.60698  -18.05917 1.000 55.49112  ? 760 HOH D O   1 
HETATM 4029 O O   . HOH Q 4 .   ? 31.92176  22.60794  -17.91815 1.000 51.34309  ? 761 HOH D O   1 
HETATM 4030 O O   . HOH Q 4 .   ? 9.89706   23.52182  -13.02724 1.000 40.45544  ? 762 HOH D O   1 
HETATM 4031 O O   . HOH Q 4 .   ? 25.96904  25.06114  -2.69075  1.000 49.41478  ? 763 HOH D O   1 
HETATM 4032 O O   . HOH Q 4 .   ? 10.40064  31.92414  -32.89352 1.000 49.78157  ? 764 HOH D O   1 
HETATM 4033 O O   . HOH Q 4 .   ? 14.79956  35.23216  -0.97457  1.000 41.65295  ? 765 HOH D O   1 
HETATM 4034 O O   . HOH Q 4 .   ? 30.57551  32.35422  -13.96450 1.000 47.51750  ? 766 HOH D O   1 
HETATM 4035 O O   . HOH Q 4 .   ? 12.98505  32.25076  -40.07030 1.000 53.03609  ? 767 HOH D O   1 
HETATM 4036 O O   . HOH Q 4 .   ? 15.90889  42.30774  -28.96685 1.000 46.74181  ? 768 HOH D O   1 
HETATM 4037 O O   . HOH Q 4 .   ? 17.12589  45.01791  -7.82628  1.000 61.51956  ? 769 HOH D O   1 
HETATM 4038 O O   . HOH Q 4 .   ? 19.56695  56.57903  -28.50677 1.000 50.77620  ? 770 HOH D O   1 
HETATM 4039 O O   . HOH Q 4 .   ? 23.61315  28.75178  7.02676   1.000 46.89892  ? 771 HOH D O   1 
HETATM 4040 O O   . HOH Q 4 .   ? 25.38025  46.32202  -21.62984 1.000 53.03127  ? 772 HOH D O   1 
HETATM 4041 O O   . HOH Q 4 .   ? 24.68943  16.77553  -23.77430 1.000 47.08707  ? 773 HOH D O   1 
HETATM 4042 O O   . HOH Q 4 .   ? 33.17828  13.25795  -15.05016 1.000 56.43376  ? 774 HOH D O   1 
HETATM 4043 O O   . HOH Q 4 .   ? 28.93460  14.12725  -19.00960 1.000 55.04230  ? 775 HOH D O   1 
HETATM 4044 O O   . HOH Q 4 .   ? 10.64686  42.55874  -5.89946  1.000 56.58546  ? 776 HOH D O   1 
HETATM 4045 O O   . HOH Q 4 .   ? 12.50627  19.47608  -9.07469  1.000 52.09376  ? 777 HOH D O   1 
HETATM 4046 O O   . HOH Q 4 .   ? 21.39595  14.31528  -22.26762 1.000 49.81339  ? 778 HOH D O   1 
HETATM 4047 O O   . HOH Q 4 .   ? 30.30787  30.21256  -9.54776  1.000 54.93389  ? 779 HOH D O   1 
HETATM 4048 O O   . HOH Q 4 .   ? 11.16044  24.22331  -21.52982 1.000 47.50870  ? 780 HOH D O   1 
HETATM 4049 O O   . HOH Q 4 .   ? 17.72650  48.32849  -40.65453 1.000 54.40787  ? 781 HOH D O   1 
HETATM 4050 O O   . HOH Q 4 .   ? 27.94374  51.54134  -28.92402 1.000 58.73276  ? 782 HOH D O   1 
HETATM 4051 O O   . HOH Q 4 .   ? 28.11738  12.46311  -2.95739  1.000 48.88478  ? 783 HOH D O   1 
HETATM 4052 O O   . HOH Q 4 .   ? 11.11074  28.53244  -9.69128  1.000 35.79480  ? 784 HOH D O   1 
HETATM 4053 O O   . HOH Q 4 .   ? 30.19976  39.77121  -18.81742 1.000 51.42305  ? 785 HOH D O   1 
HETATM 4054 O O   . HOH Q 4 .   ? 32.97565  20.97890  -9.23043  1.000 45.02755  ? 786 HOH D O   1 
HETATM 4055 O O   . HOH Q 4 .   ? 7.64011   31.08159  -24.73779 1.000 56.77097  ? 787 HOH D O   1 
HETATM 4056 O O   . HOH Q 4 .   ? 24.04678  12.73290  -22.13639 1.000 45.82159  ? 788 HOH D O   1 
HETATM 4057 O O   . HOH Q 4 .   ? 7.24416   39.30380  -9.42566  1.000 60.17780  ? 789 HOH D O   1 
HETATM 4058 O O   . HOH Q 4 .   ? 6.94861   40.03704  -35.87352 1.000 59.39067  ? 790 HOH D O   1 
HETATM 4059 O O   . HOH Q 4 .   ? 26.45006  25.16989  -29.48935 1.000 64.36894  ? 791 HOH D O   1 
HETATM 4060 O O   . HOH Q 4 .   ? 27.17870  48.79446  -24.24116 1.000 65.43169  ? 792 HOH D O   1 
HETATM 4061 O O   . HOH Q 4 .   ? 8.73536   28.12257  -22.36445 1.000 53.74414  ? 793 HOH D O   1 
HETATM 4062 O O   . HOH Q 4 .   ? 32.30598  38.24027  -23.31976 1.000 63.38786  ? 794 HOH D O   1 
HETATM 4063 O O   . HOH Q 4 .   ? 7.12920   39.58895  -14.80338 1.000 56.23161  ? 795 HOH D O   1 
HETATM 4064 O O   . HOH Q 4 .   ? 11.80260  26.36579  -11.02052 1.000 38.92939  ? 796 HOH D O   1 
HETATM 4065 O O   . HOH Q 4 .   ? 16.33569  49.28723  -28.73845 1.000 54.36283  ? 797 HOH D O   1 
HETATM 4066 O O   . HOH Q 4 .   ? 13.61649  15.41285  -14.25306 1.000 48.03731  ? 798 HOH D O   1 
HETATM 4067 O O   . HOH Q 4 .   ? 32.18967  42.49212  -31.61540 1.000 56.31573  ? 799 HOH D O   1 
HETATM 4068 O O   . HOH Q 4 .   ? 31.50640  49.99208  -31.51415 1.000 71.14508  ? 800 HOH D O   1 
HETATM 4069 O O   . HOH Q 4 .   ? 8.47996   24.31739  -18.78814 1.000 45.56225  ? 801 HOH D O   1 
HETATM 4070 O O   . HOH Q 4 .   ? 8.77530   24.82450  -15.27223 1.000 42.51228  ? 802 HOH D O   1 
HETATM 4071 O O   . HOH Q 4 .   ? 22.19858  42.22011  4.67758   1.000 68.03063  ? 803 HOH D O   1 
HETATM 4072 O O   . HOH Q 4 .   ? 6.92121   31.93836  -22.35902 1.000 54.86064  ? 804 HOH D O   1 
HETATM 4073 O O   . HOH Q 4 .   ? 10.05748  22.11894  -17.07197 1.000 45.11141  ? 805 HOH D O   1 
HETATM 4074 O O   . HOH Q 4 .   ? 20.87108  20.51658  -39.75428 1.000 70.57283  ? 806 HOH D O   1 
HETATM 4075 O O   . HOH Q 4 .   ? 8.63009   40.01627  -11.44038 1.000 56.34822  ? 807 HOH D O   1 
HETATM 4076 O O   . HOH Q 4 .   ? 26.38087  11.80222  -21.10432 1.000 58.20085  ? 808 HOH D O   1 
HETATM 4077 O O   . HOH Q 4 .   ? 24.56318  48.82922  -22.19158 1.000 58.58677  ? 809 HOH D O   1 
HETATM 4078 O O   . HOH Q 4 .   ? 8.61151   27.33280  -14.09648 1.000 44.65105  ? 810 HOH D O   1 
HETATM 4079 O O   . HOH Q 4 .   ? 17.19264  56.60128  -28.49329 1.000 61.52574  ? 811 HOH D O   1 
HETATM 4080 O O   . HOH Q 4 .   ? 18.22933  17.43660  -26.38769 1.000 55.16649  ? 812 HOH D O   1 
HETATM 4081 O O   . HOH Q 4 .   ? 5.61363   35.90588  -24.67495 1.000 57.54634  ? 813 HOH D O   1 
HETATM 4082 O O   . HOH Q 4 .   ? 6.17160   38.32115  -25.89541 1.000 53.78371  ? 814 HOH D O   1 
HETATM 4083 O O   . HOH Q 4 .   ? 23.59738  20.19246  -40.05110 1.000 65.93383  ? 815 HOH D O   1 
HETATM 4084 O O   . HOH Q 4 .   ? 14.25239  30.13939  -38.80776 1.000 66.61582  ? 816 HOH D O   1 
HETATM 4085 O O   . HOH Q 4 .   ? 30.79225  33.67778  3.41503   1.000 62.75073  ? 817 HOH D O   1 
HETATM 4086 O O   . HOH Q 4 .   ? 27.94165  45.24882  -22.77641 1.000 53.45378  ? 818 HOH D O   1 
HETATM 4087 O O   . HOH Q 4 .   ? 22.02547  20.07231  -42.17066 1.000 65.08782  ? 819 HOH D O   1 
HETATM 4088 O O   . HOH Q 4 .   ? 8.76099   20.86678  -14.85273 1.000 53.73229  ? 820 HOH D O   1 
# 
