data_8YDS
# 
_entry.id   8YDS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YDS         pdb_00008yds 10.2210/pdb8yds/pdb 
WWPDB D_1300045364 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YDS 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              yoshi.cesp@tmd.ac.jp 
_pdbx_contact_author.name_first         Yoshinori 
_pdbx_contact_author.name_last          Fujiyoshi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8070-1493 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nakamura, S.'  1 0000-0003-2253-6976 
'Numoto, N.'    2 0000-0001-6113-9792 
'Fujiyoshi, Y.' 3 0000-0002-8070-1493 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Development of a short-peptide inhibiting any SARS-CoV-2 variants based on structural biology' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nakamura, S.'  1  0000-0003-2253-6976 
primary 'Tanimura, Y.'  2  ?                   
primary 'Nomura, R.'    3  ?                   
primary 'Suzuki, H.'    4  ?                   
primary 'Nishikawa, K.' 5  ?                   
primary 'Kamegawa, A.'  6  ?                   
primary 'Numoto, N.'    7  ?                   
primary 'Tanaka, A.'    8  ?                   
primary 'Kawabata, S.'  9  ?                   
primary 'Sakaguchi, S.' 10 ?                   
primary 'Emi, A.'       11 ?                   
primary 'Suzuki, Y.'    12 ?                   
primary 'Fujiyoshi, Y.' 13 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 'SARS-CoV-2 inhibiting peptide Ce59'                                                      4821.491  1   ? ? ? ? 
2 polymer     man 'Spike protein S1'                                                                        26270.180 1   ? ? ? ? 
3 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   1   ? ? ? ? 
4 non-polymer syn GLYCEROL                                                                                  92.094    2   ? ? ? ? 
5 water       nat water                                                                                     18.015    281 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no DKEWILQKIYEIMRRLDEEGHGEASLRVSDLIYEFMKRD DKEWILQKIYEIMRRLDEEGHGEASLRVSDLIYEFMKRD A ? 
2 'polypeptide(L)' no no 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 GLYCEROL GOL 
5 water    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   LYS n 
1 3   GLU n 
1 4   TRP n 
1 5   ILE n 
1 6   LEU n 
1 7   GLN n 
1 8   LYS n 
1 9   ILE n 
1 10  TYR n 
1 11  GLU n 
1 12  ILE n 
1 13  MET n 
1 14  ARG n 
1 15  ARG n 
1 16  LEU n 
1 17  ASP n 
1 18  GLU n 
1 19  GLU n 
1 20  GLY n 
1 21  HIS n 
1 22  GLY n 
1 23  GLU n 
1 24  ALA n 
1 25  SER n 
1 26  LEU n 
1 27  ARG n 
1 28  VAL n 
1 29  SER n 
1 30  ASP n 
1 31  LEU n 
1 32  ILE n 
1 33  TYR n 
1 34  GLU n 
1 35  PHE n 
1 36  MET n 
1 37  LYS n 
1 38  ARG n 
1 39  ASP n 
2 1   THR n 
2 2   ASN n 
2 3   LEU n 
2 4   CYS n 
2 5   PRO n 
2 6   PHE n 
2 7   GLY n 
2 8   GLU n 
2 9   VAL n 
2 10  PHE n 
2 11  ASN n 
2 12  ALA n 
2 13  THR n 
2 14  ARG n 
2 15  PHE n 
2 16  ALA n 
2 17  SER n 
2 18  VAL n 
2 19  TYR n 
2 20  ALA n 
2 21  TRP n 
2 22  ASN n 
2 23  ARG n 
2 24  LYS n 
2 25  ARG n 
2 26  ILE n 
2 27  SER n 
2 28  ASN n 
2 29  CYS n 
2 30  VAL n 
2 31  ALA n 
2 32  ASP n 
2 33  TYR n 
2 34  SER n 
2 35  VAL n 
2 36  LEU n 
2 37  TYR n 
2 38  ASN n 
2 39  SER n 
2 40  ALA n 
2 41  SER n 
2 42  PHE n 
2 43  SER n 
2 44  THR n 
2 45  PHE n 
2 46  LYS n 
2 47  CYS n 
2 48  TYR n 
2 49  GLY n 
2 50  VAL n 
2 51  SER n 
2 52  PRO n 
2 53  THR n 
2 54  LYS n 
2 55  LEU n 
2 56  ASN n 
2 57  ASP n 
2 58  LEU n 
2 59  CYS n 
2 60  PHE n 
2 61  THR n 
2 62  ASN n 
2 63  VAL n 
2 64  TYR n 
2 65  ALA n 
2 66  ASP n 
2 67  SER n 
2 68  PHE n 
2 69  VAL n 
2 70  ILE n 
2 71  ARG n 
2 72  GLY n 
2 73  ASP n 
2 74  GLU n 
2 75  VAL n 
2 76  ARG n 
2 77  GLN n 
2 78  ILE n 
2 79  ALA n 
2 80  PRO n 
2 81  GLY n 
2 82  GLN n 
2 83  THR n 
2 84  GLY n 
2 85  LYS n 
2 86  ILE n 
2 87  ALA n 
2 88  ASP n 
2 89  TYR n 
2 90  ASN n 
2 91  TYR n 
2 92  LYS n 
2 93  LEU n 
2 94  PRO n 
2 95  ASP n 
2 96  ASP n 
2 97  PHE n 
2 98  THR n 
2 99  GLY n 
2 100 CYS n 
2 101 VAL n 
2 102 ILE n 
2 103 ALA n 
2 104 TRP n 
2 105 ASN n 
2 106 SER n 
2 107 ASN n 
2 108 ASN n 
2 109 LEU n 
2 110 ASP n 
2 111 SER n 
2 112 LYS n 
2 113 VAL n 
2 114 GLY n 
2 115 GLY n 
2 116 ASN n 
2 117 TYR n 
2 118 ASN n 
2 119 TYR n 
2 120 ARG n 
2 121 TYR n 
2 122 ARG n 
2 123 LEU n 
2 124 PHE n 
2 125 ARG n 
2 126 LYS n 
2 127 SER n 
2 128 ASN n 
2 129 LEU n 
2 130 LYS n 
2 131 PRO n 
2 132 PHE n 
2 133 GLU n 
2 134 ARG n 
2 135 ASP n 
2 136 ILE n 
2 137 SER n 
2 138 THR n 
2 139 GLU n 
2 140 ILE n 
2 141 TYR n 
2 142 GLN n 
2 143 ALA n 
2 144 GLY n 
2 145 SER n 
2 146 LYS n 
2 147 PRO n 
2 148 CYS n 
2 149 ASN n 
2 150 GLY n 
2 151 VAL n 
2 152 GLU n 
2 153 GLY n 
2 154 PHE n 
2 155 ASN n 
2 156 CYS n 
2 157 TYR n 
2 158 PHE n 
2 159 PRO n 
2 160 LEU n 
2 161 GLN n 
2 162 SER n 
2 163 TYR n 
2 164 GLY n 
2 165 PHE n 
2 166 GLN n 
2 167 PRO n 
2 168 THR n 
2 169 ASN n 
2 170 GLY n 
2 171 VAL n 
2 172 GLY n 
2 173 TYR n 
2 174 GLN n 
2 175 PRO n 
2 176 TYR n 
2 177 ARG n 
2 178 VAL n 
2 179 VAL n 
2 180 VAL n 
2 181 LEU n 
2 182 SER n 
2 183 PHE n 
2 184 GLU n 
2 185 LEU n 
2 186 LEU n 
2 187 HIS n 
2 188 ALA n 
2 189 PRO n 
2 190 ALA n 
2 191 THR n 
2 192 VAL n 
2 193 CYS n 
2 194 GLY n 
2 195 SER n 
2 196 ASN n 
2 197 SER n 
2 198 GLU n 
2 199 ASN n 
2 200 LEU n 
2 201 TYR n 
2 202 PHE n 
2 203 GLN n 
2 204 GLY n 
2 205 SER n 
2 206 HIS n 
2 207 HIS n 
2 208 HIS n 
2 209 HIS n 
2 210 HIS n 
2 211 HIS n 
2 212 HIS n 
2 213 HIS n 
2 214 HIS n 
2 215 HIS n 
2 216 GLY n 
2 217 LEU n 
2 218 ASN n 
2 219 ASP n 
2 220 ILE n 
2 221 PHE n 
2 222 GLU n 
2 223 ALA n 
2 224 GLN n 
2 225 LYS n 
2 226 ILE n 
2 227 GLU n 
2 228 TRP n 
2 229 HIS n 
2 230 GLU n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   230 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'S, 2' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               Expi293F 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       39 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 DGlcpNAcb1-4DGlcpNAcb1-                               'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 3 '[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}}'    LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  3 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
GOL non-polymer                  . GLYCEROL                                 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       
92.094  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   1   1   ASP ASP A . n 
A 1 2   LYS 2   2   2   LYS LYS A . n 
A 1 3   GLU 3   3   3   GLU GLU A . n 
A 1 4   TRP 4   4   4   TRP TRP A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  TYR 10  10  10  TYR TYR A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  MET 13  13  13  MET MET A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  ASP 17  17  17  ASP ASP A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  HIS 21  21  21  HIS HIS A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  SER 29  29  29  SER SER A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  TYR 33  33  33  TYR TYR A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
B 2 1   THR 1   333 333 THR THR B . n 
B 2 2   ASN 2   334 334 ASN ASN B . n 
B 2 3   LEU 3   335 335 LEU LEU B . n 
B 2 4   CYS 4   336 336 CYS CYS B . n 
B 2 5   PRO 5   337 337 PRO PRO B . n 
B 2 6   PHE 6   338 338 PHE PHE B . n 
B 2 7   GLY 7   339 339 GLY GLY B . n 
B 2 8   GLU 8   340 340 GLU GLU B . n 
B 2 9   VAL 9   341 341 VAL VAL B . n 
B 2 10  PHE 10  342 342 PHE PHE B . n 
B 2 11  ASN 11  343 343 ASN ASN B . n 
B 2 12  ALA 12  344 344 ALA ALA B . n 
B 2 13  THR 13  345 345 THR THR B . n 
B 2 14  ARG 14  346 346 ARG ARG B . n 
B 2 15  PHE 15  347 347 PHE PHE B . n 
B 2 16  ALA 16  348 348 ALA ALA B . n 
B 2 17  SER 17  349 349 SER SER B . n 
B 2 18  VAL 18  350 350 VAL VAL B . n 
B 2 19  TYR 19  351 351 TYR TYR B . n 
B 2 20  ALA 20  352 352 ALA ALA B . n 
B 2 21  TRP 21  353 353 TRP TRP B . n 
B 2 22  ASN 22  354 354 ASN ASN B . n 
B 2 23  ARG 23  355 355 ARG ARG B . n 
B 2 24  LYS 24  356 356 LYS LYS B . n 
B 2 25  ARG 25  357 357 ARG ARG B . n 
B 2 26  ILE 26  358 358 ILE ILE B . n 
B 2 27  SER 27  359 359 SER SER B . n 
B 2 28  ASN 28  360 360 ASN ASN B . n 
B 2 29  CYS 29  361 361 CYS CYS B . n 
B 2 30  VAL 30  362 362 VAL VAL B . n 
B 2 31  ALA 31  363 363 ALA ALA B . n 
B 2 32  ASP 32  364 364 ASP ASP B . n 
B 2 33  TYR 33  365 365 TYR TYR B . n 
B 2 34  SER 34  366 366 SER SER B . n 
B 2 35  VAL 35  367 367 VAL VAL B . n 
B 2 36  LEU 36  368 368 LEU LEU B . n 
B 2 37  TYR 37  369 369 TYR TYR B . n 
B 2 38  ASN 38  370 370 ASN ASN B . n 
B 2 39  SER 39  371 371 SER SER B . n 
B 2 40  ALA 40  372 372 ALA ALA B . n 
B 2 41  SER 41  373 373 SER SER B . n 
B 2 42  PHE 42  374 374 PHE PHE B . n 
B 2 43  SER 43  375 375 SER SER B . n 
B 2 44  THR 44  376 376 THR THR B . n 
B 2 45  PHE 45  377 377 PHE PHE B . n 
B 2 46  LYS 46  378 378 LYS LYS B . n 
B 2 47  CYS 47  379 379 CYS CYS B . n 
B 2 48  TYR 48  380 380 TYR TYR B . n 
B 2 49  GLY 49  381 381 GLY GLY B . n 
B 2 50  VAL 50  382 382 VAL VAL B . n 
B 2 51  SER 51  383 383 SER SER B . n 
B 2 52  PRO 52  384 384 PRO PRO B . n 
B 2 53  THR 53  385 385 THR THR B . n 
B 2 54  LYS 54  386 386 LYS LYS B . n 
B 2 55  LEU 55  387 387 LEU LEU B . n 
B 2 56  ASN 56  388 388 ASN ASN B . n 
B 2 57  ASP 57  389 389 ASP ASP B . n 
B 2 58  LEU 58  390 390 LEU LEU B . n 
B 2 59  CYS 59  391 391 CYS CYS B . n 
B 2 60  PHE 60  392 392 PHE PHE B . n 
B 2 61  THR 61  393 393 THR THR B . n 
B 2 62  ASN 62  394 394 ASN ASN B . n 
B 2 63  VAL 63  395 395 VAL VAL B . n 
B 2 64  TYR 64  396 396 TYR TYR B . n 
B 2 65  ALA 65  397 397 ALA ALA B . n 
B 2 66  ASP 66  398 398 ASP ASP B . n 
B 2 67  SER 67  399 399 SER SER B . n 
B 2 68  PHE 68  400 400 PHE PHE B . n 
B 2 69  VAL 69  401 401 VAL VAL B . n 
B 2 70  ILE 70  402 402 ILE ILE B . n 
B 2 71  ARG 71  403 403 ARG ARG B . n 
B 2 72  GLY 72  404 404 GLY GLY B . n 
B 2 73  ASP 73  405 405 ASP ASP B . n 
B 2 74  GLU 74  406 406 GLU GLU B . n 
B 2 75  VAL 75  407 407 VAL VAL B . n 
B 2 76  ARG 76  408 408 ARG ARG B . n 
B 2 77  GLN 77  409 409 GLN GLN B . n 
B 2 78  ILE 78  410 410 ILE ILE B . n 
B 2 79  ALA 79  411 411 ALA ALA B . n 
B 2 80  PRO 80  412 412 PRO PRO B . n 
B 2 81  GLY 81  413 413 GLY GLY B . n 
B 2 82  GLN 82  414 414 GLN GLN B . n 
B 2 83  THR 83  415 415 THR THR B . n 
B 2 84  GLY 84  416 416 GLY GLY B . n 
B 2 85  LYS 85  417 417 LYS LYS B . n 
B 2 86  ILE 86  418 418 ILE ILE B . n 
B 2 87  ALA 87  419 419 ALA ALA B . n 
B 2 88  ASP 88  420 420 ASP ASP B . n 
B 2 89  TYR 89  421 421 TYR TYR B . n 
B 2 90  ASN 90  422 422 ASN ASN B . n 
B 2 91  TYR 91  423 423 TYR TYR B . n 
B 2 92  LYS 92  424 424 LYS LYS B . n 
B 2 93  LEU 93  425 425 LEU LEU B . n 
B 2 94  PRO 94  426 426 PRO PRO B . n 
B 2 95  ASP 95  427 427 ASP ASP B . n 
B 2 96  ASP 96  428 428 ASP ASP B . n 
B 2 97  PHE 97  429 429 PHE PHE B . n 
B 2 98  THR 98  430 430 THR THR B . n 
B 2 99  GLY 99  431 431 GLY GLY B . n 
B 2 100 CYS 100 432 432 CYS CYS B . n 
B 2 101 VAL 101 433 433 VAL VAL B . n 
B 2 102 ILE 102 434 434 ILE ILE B . n 
B 2 103 ALA 103 435 435 ALA ALA B . n 
B 2 104 TRP 104 436 436 TRP TRP B . n 
B 2 105 ASN 105 437 437 ASN ASN B . n 
B 2 106 SER 106 438 438 SER SER B . n 
B 2 107 ASN 107 439 439 ASN ASN B . n 
B 2 108 ASN 108 440 440 ASN ASN B . n 
B 2 109 LEU 109 441 441 LEU LEU B . n 
B 2 110 ASP 110 442 442 ASP ASP B . n 
B 2 111 SER 111 443 443 SER SER B . n 
B 2 112 LYS 112 444 444 LYS LYS B . n 
B 2 113 VAL 113 445 445 VAL VAL B . n 
B 2 114 GLY 114 446 446 GLY GLY B . n 
B 2 115 GLY 115 447 447 GLY GLY B . n 
B 2 116 ASN 116 448 448 ASN ASN B . n 
B 2 117 TYR 117 449 449 TYR TYR B . n 
B 2 118 ASN 118 450 450 ASN ASN B . n 
B 2 119 TYR 119 451 451 TYR TYR B . n 
B 2 120 ARG 120 452 452 ARG ARG B . n 
B 2 121 TYR 121 453 453 TYR TYR B . n 
B 2 122 ARG 122 454 454 ARG ARG B . n 
B 2 123 LEU 123 455 455 LEU LEU B . n 
B 2 124 PHE 124 456 456 PHE PHE B . n 
B 2 125 ARG 125 457 457 ARG ARG B . n 
B 2 126 LYS 126 458 458 LYS LYS B . n 
B 2 127 SER 127 459 459 SER SER B . n 
B 2 128 ASN 128 460 460 ASN ASN B . n 
B 2 129 LEU 129 461 461 LEU LEU B . n 
B 2 130 LYS 130 462 462 LYS LYS B . n 
B 2 131 PRO 131 463 463 PRO PRO B . n 
B 2 132 PHE 132 464 464 PHE PHE B . n 
B 2 133 GLU 133 465 465 GLU GLU B . n 
B 2 134 ARG 134 466 466 ARG ARG B . n 
B 2 135 ASP 135 467 467 ASP ASP B . n 
B 2 136 ILE 136 468 468 ILE ILE B . n 
B 2 137 SER 137 469 469 SER SER B . n 
B 2 138 THR 138 470 470 THR THR B . n 
B 2 139 GLU 139 471 471 GLU GLU B . n 
B 2 140 ILE 140 472 472 ILE ILE B . n 
B 2 141 TYR 141 473 473 TYR TYR B . n 
B 2 142 GLN 142 474 474 GLN GLN B . n 
B 2 143 ALA 143 475 475 ALA ALA B . n 
B 2 144 GLY 144 476 476 GLY GLY B . n 
B 2 145 SER 145 477 477 SER SER B . n 
B 2 146 LYS 146 478 478 LYS LYS B . n 
B 2 147 PRO 147 479 479 PRO PRO B . n 
B 2 148 CYS 148 480 480 CYS CYS B . n 
B 2 149 ASN 149 481 481 ASN ASN B . n 
B 2 150 GLY 150 482 482 GLY GLY B . n 
B 2 151 VAL 151 483 483 VAL VAL B . n 
B 2 152 GLU 152 484 484 GLU GLU B . n 
B 2 153 GLY 153 485 485 GLY GLY B . n 
B 2 154 PHE 154 486 486 PHE PHE B . n 
B 2 155 ASN 155 487 487 ASN ASN B . n 
B 2 156 CYS 156 488 488 CYS CYS B . n 
B 2 157 TYR 157 489 489 TYR TYR B . n 
B 2 158 PHE 158 490 490 PHE PHE B . n 
B 2 159 PRO 159 491 491 PRO PRO B . n 
B 2 160 LEU 160 492 492 LEU LEU B . n 
B 2 161 GLN 161 493 493 GLN GLN B . n 
B 2 162 SER 162 494 494 SER SER B . n 
B 2 163 TYR 163 495 495 TYR TYR B . n 
B 2 164 GLY 164 496 496 GLY GLY B . n 
B 2 165 PHE 165 497 497 PHE PHE B . n 
B 2 166 GLN 166 498 498 GLN GLN B . n 
B 2 167 PRO 167 499 499 PRO PRO B . n 
B 2 168 THR 168 500 500 THR THR B . n 
B 2 169 ASN 169 501 501 ASN ASN B . n 
B 2 170 GLY 170 502 502 GLY GLY B . n 
B 2 171 VAL 171 503 503 VAL VAL B . n 
B 2 172 GLY 172 504 504 GLY GLY B . n 
B 2 173 TYR 173 505 505 TYR TYR B . n 
B 2 174 GLN 174 506 506 GLN GLN B . n 
B 2 175 PRO 175 507 507 PRO PRO B . n 
B 2 176 TYR 176 508 508 TYR TYR B . n 
B 2 177 ARG 177 509 509 ARG ARG B . n 
B 2 178 VAL 178 510 510 VAL VAL B . n 
B 2 179 VAL 179 511 511 VAL VAL B . n 
B 2 180 VAL 180 512 512 VAL VAL B . n 
B 2 181 LEU 181 513 513 LEU LEU B . n 
B 2 182 SER 182 514 514 SER SER B . n 
B 2 183 PHE 183 515 515 PHE PHE B . n 
B 2 184 GLU 184 516 516 GLU GLU B . n 
B 2 185 LEU 185 517 517 LEU LEU B . n 
B 2 186 LEU 186 518 518 LEU LEU B . n 
B 2 187 HIS 187 519 519 HIS HIS B . n 
B 2 188 ALA 188 520 520 ALA ALA B . n 
B 2 189 PRO 189 521 521 PRO PRO B . n 
B 2 190 ALA 190 522 522 ALA ALA B . n 
B 2 191 THR 191 523 523 THR THR B . n 
B 2 192 VAL 192 524 524 VAL VAL B . n 
B 2 193 CYS 193 525 525 CYS CYS B . n 
B 2 194 GLY 194 526 526 GLY GLY B . n 
B 2 195 SER 195 527 527 SER SER B . n 
B 2 196 ASN 196 528 528 ASN ASN B . n 
B 2 197 SER 197 529 529 SER SER B . n 
B 2 198 GLU 198 530 530 GLU GLU B . n 
B 2 199 ASN 199 531 ?   ?   ?   B . n 
B 2 200 LEU 200 532 ?   ?   ?   B . n 
B 2 201 TYR 201 533 ?   ?   ?   B . n 
B 2 202 PHE 202 534 ?   ?   ?   B . n 
B 2 203 GLN 203 535 ?   ?   ?   B . n 
B 2 204 GLY 204 536 ?   ?   ?   B . n 
B 2 205 SER 205 537 ?   ?   ?   B . n 
B 2 206 HIS 206 538 ?   ?   ?   B . n 
B 2 207 HIS 207 539 ?   ?   ?   B . n 
B 2 208 HIS 208 540 ?   ?   ?   B . n 
B 2 209 HIS 209 541 ?   ?   ?   B . n 
B 2 210 HIS 210 542 ?   ?   ?   B . n 
B 2 211 HIS 211 543 ?   ?   ?   B . n 
B 2 212 HIS 212 544 ?   ?   ?   B . n 
B 2 213 HIS 213 545 ?   ?   ?   B . n 
B 2 214 HIS 214 546 ?   ?   ?   B . n 
B 2 215 HIS 215 547 ?   ?   ?   B . n 
B 2 216 GLY 216 548 ?   ?   ?   B . n 
B 2 217 LEU 217 549 ?   ?   ?   B . n 
B 2 218 ASN 218 550 ?   ?   ?   B . n 
B 2 219 ASP 219 551 ?   ?   ?   B . n 
B 2 220 ILE 220 552 ?   ?   ?   B . n 
B 2 221 PHE 221 553 ?   ?   ?   B . n 
B 2 222 GLU 222 554 ?   ?   ?   B . n 
B 2 223 ALA 223 555 ?   ?   ?   B . n 
B 2 224 GLN 224 556 ?   ?   ?   B . n 
B 2 225 LYS 225 557 ?   ?   ?   B . n 
B 2 226 ILE 226 558 ?   ?   ?   B . n 
B 2 227 GLU 227 559 ?   ?   ?   B . n 
B 2 228 TRP 228 560 ?   ?   ?   B . n 
B 2 229 HIS 229 561 ?   ?   ?   B . n 
B 2 230 GLU 230 562 ?   ?   ?   B . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 3 NAG 1 C NAG 1 B NAG 605 n 
C 3 NAG 2 C NAG 2 B NAG 606 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 GOL 1   601 603 GOL GOL B . 
E 4 GOL 1   602 607 GOL GOL B . 
F 5 HOH 1   101 104 HOH HOH A . 
F 5 HOH 2   102 244 HOH HOH A . 
F 5 HOH 3   103 262 HOH HOH A . 
F 5 HOH 4   104 87  HOH HOH A . 
F 5 HOH 5   105 106 HOH HOH A . 
F 5 HOH 6   106 95  HOH HOH A . 
F 5 HOH 7   107 165 HOH HOH A . 
F 5 HOH 8   108 130 HOH HOH A . 
F 5 HOH 9   109 74  HOH HOH A . 
F 5 HOH 10  110 159 HOH HOH A . 
F 5 HOH 11  111 80  HOH HOH A . 
F 5 HOH 12  112 127 HOH HOH A . 
F 5 HOH 13  113 140 HOH HOH A . 
F 5 HOH 14  114 263 HOH HOH A . 
F 5 HOH 15  115 53  HOH HOH A . 
F 5 HOH 16  116 38  HOH HOH A . 
F 5 HOH 17  117 258 HOH HOH A . 
F 5 HOH 18  118 279 HOH HOH A . 
F 5 HOH 19  119 119 HOH HOH A . 
F 5 HOH 20  120 280 HOH HOH A . 
F 5 HOH 21  121 257 HOH HOH A . 
F 5 HOH 22  122 113 HOH HOH A . 
F 5 HOH 23  123 245 HOH HOH A . 
F 5 HOH 24  124 124 HOH HOH A . 
F 5 HOH 25  125 278 HOH HOH A . 
F 5 HOH 26  126 241 HOH HOH A . 
F 5 HOH 27  127 209 HOH HOH A . 
F 5 HOH 28  128 123 HOH HOH A . 
F 5 HOH 29  129 217 HOH HOH A . 
F 5 HOH 30  130 145 HOH HOH A . 
F 5 HOH 31  131 85  HOH HOH A . 
F 5 HOH 32  132 292 HOH HOH A . 
G 5 HOH 1   701 46  HOH HOH B . 
G 5 HOH 2   702 112 HOH HOH B . 
G 5 HOH 3   703 224 HOH HOH B . 
G 5 HOH 4   704 218 HOH HOH B . 
G 5 HOH 5   705 214 HOH HOH B . 
G 5 HOH 6   706 200 HOH HOH B . 
G 5 HOH 7   707 10  HOH HOH B . 
G 5 HOH 8   708 157 HOH HOH B . 
G 5 HOH 9   709 182 HOH HOH B . 
G 5 HOH 10  710 206 HOH HOH B . 
G 5 HOH 11  711 60  HOH HOH B . 
G 5 HOH 12  712 92  HOH HOH B . 
G 5 HOH 13  713 147 HOH HOH B . 
G 5 HOH 14  714 197 HOH HOH B . 
G 5 HOH 15  715 120 HOH HOH B . 
G 5 HOH 16  716 103 HOH HOH B . 
G 5 HOH 17  717 192 HOH HOH B . 
G 5 HOH 18  718 181 HOH HOH B . 
G 5 HOH 19  719 154 HOH HOH B . 
G 5 HOH 20  720 5   HOH HOH B . 
G 5 HOH 21  721 73  HOH HOH B . 
G 5 HOH 22  722 196 HOH HOH B . 
G 5 HOH 23  723 250 HOH HOH B . 
G 5 HOH 24  724 179 HOH HOH B . 
G 5 HOH 25  725 97  HOH HOH B . 
G 5 HOH 26  726 216 HOH HOH B . 
G 5 HOH 27  727 291 HOH HOH B . 
G 5 HOH 28  728 48  HOH HOH B . 
G 5 HOH 29  729 134 HOH HOH B . 
G 5 HOH 30  730 43  HOH HOH B . 
G 5 HOH 31  731 62  HOH HOH B . 
G 5 HOH 32  732 105 HOH HOH B . 
G 5 HOH 33  733 64  HOH HOH B . 
G 5 HOH 34  734 79  HOH HOH B . 
G 5 HOH 35  735 139 HOH HOH B . 
G 5 HOH 36  736 293 HOH HOH B . 
G 5 HOH 37  737 23  HOH HOH B . 
G 5 HOH 38  738 211 HOH HOH B . 
G 5 HOH 39  739 89  HOH HOH B . 
G 5 HOH 40  740 160 HOH HOH B . 
G 5 HOH 41  741 31  HOH HOH B . 
G 5 HOH 42  742 50  HOH HOH B . 
G 5 HOH 43  743 110 HOH HOH B . 
G 5 HOH 44  744 76  HOH HOH B . 
G 5 HOH 45  745 116 HOH HOH B . 
G 5 HOH 46  746 2   HOH HOH B . 
G 5 HOH 47  747 174 HOH HOH B . 
G 5 HOH 48  748 42  HOH HOH B . 
G 5 HOH 49  749 17  HOH HOH B . 
G 5 HOH 50  750 114 HOH HOH B . 
G 5 HOH 51  751 128 HOH HOH B . 
G 5 HOH 52  752 72  HOH HOH B . 
G 5 HOH 53  753 260 HOH HOH B . 
G 5 HOH 54  754 40  HOH HOH B . 
G 5 HOH 55  755 71  HOH HOH B . 
G 5 HOH 56  756 146 HOH HOH B . 
G 5 HOH 57  757 61  HOH HOH B . 
G 5 HOH 58  758 101 HOH HOH B . 
G 5 HOH 59  759 55  HOH HOH B . 
G 5 HOH 60  760 240 HOH HOH B . 
G 5 HOH 61  761 94  HOH HOH B . 
G 5 HOH 62  762 69  HOH HOH B . 
G 5 HOH 63  763 161 HOH HOH B . 
G 5 HOH 64  764 20  HOH HOH B . 
G 5 HOH 65  765 57  HOH HOH B . 
G 5 HOH 66  766 7   HOH HOH B . 
G 5 HOH 67  767 96  HOH HOH B . 
G 5 HOH 68  768 3   HOH HOH B . 
G 5 HOH 69  769 131 HOH HOH B . 
G 5 HOH 70  770 82  HOH HOH B . 
G 5 HOH 71  771 32  HOH HOH B . 
G 5 HOH 72  772 13  HOH HOH B . 
G 5 HOH 73  773 36  HOH HOH B . 
G 5 HOH 74  774 34  HOH HOH B . 
G 5 HOH 75  775 11  HOH HOH B . 
G 5 HOH 76  776 33  HOH HOH B . 
G 5 HOH 77  777 186 HOH HOH B . 
G 5 HOH 78  778 109 HOH HOH B . 
G 5 HOH 79  779 63  HOH HOH B . 
G 5 HOH 80  780 6   HOH HOH B . 
G 5 HOH 81  781 177 HOH HOH B . 
G 5 HOH 82  782 111 HOH HOH B . 
G 5 HOH 83  783 229 HOH HOH B . 
G 5 HOH 84  784 19  HOH HOH B . 
G 5 HOH 85  785 93  HOH HOH B . 
G 5 HOH 86  786 75  HOH HOH B . 
G 5 HOH 87  787 24  HOH HOH B . 
G 5 HOH 88  788 297 HOH HOH B . 
G 5 HOH 89  789 66  HOH HOH B . 
G 5 HOH 90  790 284 HOH HOH B . 
G 5 HOH 91  791 21  HOH HOH B . 
G 5 HOH 92  792 288 HOH HOH B . 
G 5 HOH 93  793 155 HOH HOH B . 
G 5 HOH 94  794 84  HOH HOH B . 
G 5 HOH 95  795 4   HOH HOH B . 
G 5 HOH 96  796 18  HOH HOH B . 
G 5 HOH 97  797 28  HOH HOH B . 
G 5 HOH 98  798 125 HOH HOH B . 
G 5 HOH 99  799 14  HOH HOH B . 
G 5 HOH 100 800 126 HOH HOH B . 
G 5 HOH 101 801 27  HOH HOH B . 
G 5 HOH 102 802 8   HOH HOH B . 
G 5 HOH 103 803 172 HOH HOH B . 
G 5 HOH 104 804 223 HOH HOH B . 
G 5 HOH 105 805 243 HOH HOH B . 
G 5 HOH 106 806 49  HOH HOH B . 
G 5 HOH 107 807 202 HOH HOH B . 
G 5 HOH 108 808 70  HOH HOH B . 
G 5 HOH 109 809 78  HOH HOH B . 
G 5 HOH 110 810 54  HOH HOH B . 
G 5 HOH 111 811 45  HOH HOH B . 
G 5 HOH 112 812 180 HOH HOH B . 
G 5 HOH 113 813 1   HOH HOH B . 
G 5 HOH 114 814 167 HOH HOH B . 
G 5 HOH 115 815 175 HOH HOH B . 
G 5 HOH 116 816 12  HOH HOH B . 
G 5 HOH 117 817 253 HOH HOH B . 
G 5 HOH 118 818 183 HOH HOH B . 
G 5 HOH 119 819 52  HOH HOH B . 
G 5 HOH 120 820 195 HOH HOH B . 
G 5 HOH 121 821 98  HOH HOH B . 
G 5 HOH 122 822 51  HOH HOH B . 
G 5 HOH 123 823 22  HOH HOH B . 
G 5 HOH 124 824 67  HOH HOH B . 
G 5 HOH 125 825 65  HOH HOH B . 
G 5 HOH 126 826 77  HOH HOH B . 
G 5 HOH 127 827 295 HOH HOH B . 
G 5 HOH 128 828 47  HOH HOH B . 
G 5 HOH 129 829 115 HOH HOH B . 
G 5 HOH 130 830 121 HOH HOH B . 
G 5 HOH 131 831 16  HOH HOH B . 
G 5 HOH 132 832 264 HOH HOH B . 
G 5 HOH 133 833 256 HOH HOH B . 
G 5 HOH 134 834 88  HOH HOH B . 
G 5 HOH 135 835 129 HOH HOH B . 
G 5 HOH 136 836 83  HOH HOH B . 
G 5 HOH 137 837 59  HOH HOH B . 
G 5 HOH 138 838 29  HOH HOH B . 
G 5 HOH 139 839 148 HOH HOH B . 
G 5 HOH 140 840 39  HOH HOH B . 
G 5 HOH 141 841 170 HOH HOH B . 
G 5 HOH 142 842 153 HOH HOH B . 
G 5 HOH 143 843 30  HOH HOH B . 
G 5 HOH 144 844 201 HOH HOH B . 
G 5 HOH 145 845 173 HOH HOH B . 
G 5 HOH 146 846 185 HOH HOH B . 
G 5 HOH 147 847 41  HOH HOH B . 
G 5 HOH 148 848 35  HOH HOH B . 
G 5 HOH 149 849 259 HOH HOH B . 
G 5 HOH 150 850 150 HOH HOH B . 
G 5 HOH 151 851 227 HOH HOH B . 
G 5 HOH 152 852 26  HOH HOH B . 
G 5 HOH 153 853 149 HOH HOH B . 
G 5 HOH 154 854 58  HOH HOH B . 
G 5 HOH 155 855 199 HOH HOH B . 
G 5 HOH 156 856 100 HOH HOH B . 
G 5 HOH 157 857 99  HOH HOH B . 
G 5 HOH 158 858 176 HOH HOH B . 
G 5 HOH 159 859 15  HOH HOH B . 
G 5 HOH 160 860 44  HOH HOH B . 
G 5 HOH 161 861 171 HOH HOH B . 
G 5 HOH 162 862 138 HOH HOH B . 
G 5 HOH 163 863 251 HOH HOH B . 
G 5 HOH 164 864 254 HOH HOH B . 
G 5 HOH 165 865 261 HOH HOH B . 
G 5 HOH 166 866 25  HOH HOH B . 
G 5 HOH 167 867 81  HOH HOH B . 
G 5 HOH 168 868 294 HOH HOH B . 
G 5 HOH 169 869 56  HOH HOH B . 
G 5 HOH 170 870 233 HOH HOH B . 
G 5 HOH 171 871 283 HOH HOH B . 
G 5 HOH 172 872 237 HOH HOH B . 
G 5 HOH 173 873 86  HOH HOH B . 
G 5 HOH 174 874 151 HOH HOH B . 
G 5 HOH 175 875 190 HOH HOH B . 
G 5 HOH 176 876 212 HOH HOH B . 
G 5 HOH 177 877 249 HOH HOH B . 
G 5 HOH 178 878 90  HOH HOH B . 
G 5 HOH 179 879 91  HOH HOH B . 
G 5 HOH 180 880 168 HOH HOH B . 
G 5 HOH 181 881 136 HOH HOH B . 
G 5 HOH 182 882 117 HOH HOH B . 
G 5 HOH 183 883 187 HOH HOH B . 
G 5 HOH 184 884 234 HOH HOH B . 
G 5 HOH 185 885 188 HOH HOH B . 
G 5 HOH 186 886 169 HOH HOH B . 
G 5 HOH 187 887 270 HOH HOH B . 
G 5 HOH 188 888 193 HOH HOH B . 
G 5 HOH 189 889 268 HOH HOH B . 
G 5 HOH 190 890 266 HOH HOH B . 
G 5 HOH 191 891 230 HOH HOH B . 
G 5 HOH 192 892 275 HOH HOH B . 
G 5 HOH 193 893 285 HOH HOH B . 
G 5 HOH 194 894 239 HOH HOH B . 
G 5 HOH 195 895 163 HOH HOH B . 
G 5 HOH 196 896 143 HOH HOH B . 
G 5 HOH 197 897 282 HOH HOH B . 
G 5 HOH 198 898 273 HOH HOH B . 
G 5 HOH 199 899 152 HOH HOH B . 
G 5 HOH 200 900 194 HOH HOH B . 
G 5 HOH 201 901 287 HOH HOH B . 
G 5 HOH 202 902 189 HOH HOH B . 
G 5 HOH 203 903 118 HOH HOH B . 
G 5 HOH 204 904 135 HOH HOH B . 
G 5 HOH 205 905 108 HOH HOH B . 
G 5 HOH 206 906 235 HOH HOH B . 
G 5 HOH 207 907 272 HOH HOH B . 
G 5 HOH 208 908 296 HOH HOH B . 
G 5 HOH 209 909 277 HOH HOH B . 
G 5 HOH 210 910 133 HOH HOH B . 
G 5 HOH 211 911 208 HOH HOH B . 
G 5 HOH 212 912 248 HOH HOH B . 
G 5 HOH 213 913 242 HOH HOH B . 
G 5 HOH 214 914 207 HOH HOH B . 
G 5 HOH 215 915 191 HOH HOH B . 
G 5 HOH 216 916 232 HOH HOH B . 
G 5 HOH 217 917 137 HOH HOH B . 
G 5 HOH 218 918 246 HOH HOH B . 
G 5 HOH 219 919 164 HOH HOH B . 
G 5 HOH 220 920 166 HOH HOH B . 
G 5 HOH 221 921 238 HOH HOH B . 
G 5 HOH 222 922 281 HOH HOH B . 
G 5 HOH 223 923 142 HOH HOH B . 
G 5 HOH 224 924 156 HOH HOH B . 
G 5 HOH 225 925 102 HOH HOH B . 
G 5 HOH 226 926 122 HOH HOH B . 
G 5 HOH 227 927 141 HOH HOH B . 
G 5 HOH 228 928 68  HOH HOH B . 
G 5 HOH 229 929 231 HOH HOH B . 
G 5 HOH 230 930 184 HOH HOH B . 
G 5 HOH 231 931 247 HOH HOH B . 
G 5 HOH 232 932 204 HOH HOH B . 
G 5 HOH 233 933 213 HOH HOH B . 
G 5 HOH 234 934 37  HOH HOH B . 
G 5 HOH 235 935 203 HOH HOH B . 
G 5 HOH 236 936 269 HOH HOH B . 
G 5 HOH 237 937 158 HOH HOH B . 
G 5 HOH 238 938 132 HOH HOH B . 
G 5 HOH 239 939 219 HOH HOH B . 
G 5 HOH 240 940 107 HOH HOH B . 
G 5 HOH 241 941 210 HOH HOH B . 
G 5 HOH 242 942 215 HOH HOH B . 
G 5 HOH 243 943 144 HOH HOH B . 
G 5 HOH 244 944 252 HOH HOH B . 
G 5 HOH 245 945 198 HOH HOH B . 
G 5 HOH 246 946 178 HOH HOH B . 
G 5 HOH 247 947 205 HOH HOH B . 
G 5 HOH 248 948 226 HOH HOH B . 
G 5 HOH 249 949 255 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YDS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.050 
_cell.length_a_esd                 ? 
_cell.length_b                     74.050 
_cell.length_b_esd                 ? 
_cell.length_c                     101.000 
_cell.length_c_esd                 ? 
_cell.volume                       479625.352 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YDS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YDS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.57 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.16 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M BICINE (pH 9.0), 20% PEG 6000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          26.96 
_reflns.entry_id                                       8YDS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.82 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29186 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          34.19 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.82 
_reflns_shell.d_res_low                                     1.93 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4499 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.900 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.40 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YDS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             39.68 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25772 
_refine.ls_number_reflns_R_free                  1291 
_refine.ls_number_reflns_R_work                  24481 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.98 
_refine.ls_percent_reflns_R_free                 5.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1858 
_refine.ls_R_factor_R_free                       0.2257 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1837 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.9262 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2139 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        39.68 
_refine_hist.number_atoms_solvent             281 
_refine_hist.number_atoms_total               2229 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1908 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         40 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0064  ? 1994 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7368  ? 2697 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0512  ? 284  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0067  ? 350  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.6191 ? 727  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.98  . . 137 2637 99.82  . . . . 0.2234 . . . . . . . . . . . 0.2606 
'X-RAY DIFFRACTION' 1.98 2.07  . . 142 2702 99.96  . . . . 0.2004 . . . . . . . . . . . 0.2804 
'X-RAY DIFFRACTION' 2.07 2.17  . . 146 2680 100.00 . . . . 0.2062 . . . . . . . . . . . 0.2771 
'X-RAY DIFFRACTION' 2.18 2.31  . . 142 2678 100.00 . . . . 0.2061 . . . . . . . . . . . 0.2382 
'X-RAY DIFFRACTION' 2.31 2.49  . . 141 2697 100.00 . . . . 0.2000 . . . . . . . . . . . 0.2415 
'X-RAY DIFFRACTION' 2.49 2.74  . . 142 2721 100.00 . . . . 0.2005 . . . . . . . . . . . 0.2486 
'X-RAY DIFFRACTION' 2.74 3.14  . . 140 2738 100.00 . . . . 0.1866 . . . . . . . . . . . 0.2127 
'X-RAY DIFFRACTION' 3.14 3.95  . . 146 2742 100.00 . . . . 0.1701 . . . . . . . . . . . 0.2257 
'X-RAY DIFFRACTION' 3.95 39.68 . . 155 2886 100.00 . . . . 0.1641 . . . . . . . . . . . 0.1927 
# 
_struct.entry_id                     8YDS 
_struct.title                        
'Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant spike protein in complex with Ce59' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YDS 
_struct_keywords.text            'RBD, VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8YDS        8YDS   ? 1 ? 1   
2 UNP SPIKE_SARS2 P0DTC2 ? 2 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
;
333 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YDS A 1 ? 39  ? 8YDS   1   ? 39  ? 1   39  
2 2 8YDS B 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8YDS ARG B 120 ? UNP P0DTC2 LEU 452 variant          452 1  
2 8YDS LYS B 146 ? UNP P0DTC2 THR 478 variant          478 2  
2 8YDS SER B 195 ? UNP P0DTC2 ?   ?   'expression tag' 527 3  
2 8YDS ASN B 196 ? UNP P0DTC2 ?   ?   'expression tag' 528 4  
2 8YDS SER B 197 ? UNP P0DTC2 ?   ?   'expression tag' 529 5  
2 8YDS GLU B 198 ? UNP P0DTC2 ?   ?   'expression tag' 530 6  
2 8YDS ASN B 199 ? UNP P0DTC2 ?   ?   'expression tag' 531 7  
2 8YDS LEU B 200 ? UNP P0DTC2 ?   ?   'expression tag' 532 8  
2 8YDS TYR B 201 ? UNP P0DTC2 ?   ?   'expression tag' 533 9  
2 8YDS PHE B 202 ? UNP P0DTC2 ?   ?   'expression tag' 534 10 
2 8YDS GLN B 203 ? UNP P0DTC2 ?   ?   'expression tag' 535 11 
2 8YDS GLY B 204 ? UNP P0DTC2 ?   ?   'expression tag' 536 12 
2 8YDS SER B 205 ? UNP P0DTC2 ?   ?   'expression tag' 537 13 
2 8YDS HIS B 206 ? UNP P0DTC2 ?   ?   'expression tag' 538 14 
2 8YDS HIS B 207 ? UNP P0DTC2 ?   ?   'expression tag' 539 15 
2 8YDS HIS B 208 ? UNP P0DTC2 ?   ?   'expression tag' 540 16 
2 8YDS HIS B 209 ? UNP P0DTC2 ?   ?   'expression tag' 541 17 
2 8YDS HIS B 210 ? UNP P0DTC2 ?   ?   'expression tag' 542 18 
2 8YDS HIS B 211 ? UNP P0DTC2 ?   ?   'expression tag' 543 19 
2 8YDS HIS B 212 ? UNP P0DTC2 ?   ?   'expression tag' 544 20 
2 8YDS HIS B 213 ? UNP P0DTC2 ?   ?   'expression tag' 545 21 
2 8YDS HIS B 214 ? UNP P0DTC2 ?   ?   'expression tag' 546 22 
2 8YDS HIS B 215 ? UNP P0DTC2 ?   ?   'expression tag' 547 23 
2 8YDS GLY B 216 ? UNP P0DTC2 ?   ?   'expression tag' 548 24 
2 8YDS LEU B 217 ? UNP P0DTC2 ?   ?   'expression tag' 549 25 
2 8YDS ASN B 218 ? UNP P0DTC2 ?   ?   'expression tag' 550 26 
2 8YDS ASP B 219 ? UNP P0DTC2 ?   ?   'expression tag' 551 27 
2 8YDS ILE B 220 ? UNP P0DTC2 ?   ?   'expression tag' 552 28 
2 8YDS PHE B 221 ? UNP P0DTC2 ?   ?   'expression tag' 553 29 
2 8YDS GLU B 222 ? UNP P0DTC2 ?   ?   'expression tag' 554 30 
2 8YDS ALA B 223 ? UNP P0DTC2 ?   ?   'expression tag' 555 31 
2 8YDS GLN B 224 ? UNP P0DTC2 ?   ?   'expression tag' 556 32 
2 8YDS LYS B 225 ? UNP P0DTC2 ?   ?   'expression tag' 557 33 
2 8YDS ILE B 226 ? UNP P0DTC2 ?   ?   'expression tag' 558 34 
2 8YDS GLU B 227 ? UNP P0DTC2 ?   ?   'expression tag' 559 35 
2 8YDS TRP B 228 ? UNP P0DTC2 ?   ?   'expression tag' 560 36 
2 8YDS HIS B 229 ? UNP P0DTC2 ?   ?   'expression tag' 561 37 
2 8YDS GLU B 230 ? UNP P0DTC2 ?   ?   'expression tag' 562 38 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3060  ? 
1 MORE         1     ? 
1 'SSA (A^2)'  12040 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LYS A 2   ? GLU A 19  ? LYS A 2   GLU A 19  1 ? 18 
HELX_P HELX_P2  AA2 HIS A 21  ? ARG A 38  ? HIS A 21  ARG A 38  1 ? 18 
HELX_P HELX_P3  AA3 PRO B 5   ? ASN B 11  ? PRO B 337 ASN B 343 1 ? 7  
HELX_P HELX_P4  AA4 SER B 17  ? TRP B 21  ? SER B 349 TRP B 353 5 ? 5  
HELX_P HELX_P5  AA5 ASP B 32  ? ASN B 38  ? ASP B 364 ASN B 370 1 ? 7  
HELX_P HELX_P6  AA6 SER B 51  ? ASN B 56  ? SER B 383 ASN B 388 1 ? 6  
HELX_P HELX_P7  AA7 ASP B 73  ? ILE B 78  ? ASP B 405 ILE B 410 5 ? 6  
HELX_P HELX_P8  AA8 GLY B 84  ? ASN B 90  ? GLY B 416 ASN B 422 1 ? 7  
HELX_P HELX_P9  AA9 SER B 106 ? SER B 111 ? SER B 438 SER B 443 1 ? 6  
HELX_P HELX_P10 AB1 GLY B 170 ? TYR B 173 ? GLY B 502 TYR B 505 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? B CYS 4   SG  ? ? ? 1_555 B CYS 29  SG ? ? B CYS 336 B CYS 361 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf2 disulf ?    ? B CYS 47  SG  ? ? ? 1_555 B CYS 100 SG ? ? B CYS 379 B CYS 432 1_555 ? ? ? ? ? ? ? 2.071 ? ?               
disulf3 disulf ?    ? B CYS 59  SG  ? ? ? 1_555 B CYS 193 SG ? ? B CYS 391 B CYS 525 1_555 ? ? ? ? ? ? ? 2.048 ? ?               
disulf4 disulf ?    ? B CYS 148 SG  ? ? ? 1_555 B CYS 156 SG ? ? B CYS 480 B CYS 488 1_555 ? ? ? ? ? ? ? 2.073 ? ?               
covale1 covale one  ? B ASN 11  ND2 ? ? ? 1_555 C NAG .   C1 ? ? B ASN 343 C NAG 1   1_555 ? ? ? ? ? ? ? 1.431 ? N-Glycosylation 
covale2 covale both ? C NAG .   O4  ? ? ? 1_555 C NAG .   C1 ? ? C NAG 1   C NAG 2   1_555 ? ? ? ? ? ? ? 1.440 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG C .   ? ASN B 11  ? NAG C 1   ? 1_555 ASN B 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS B 4   ? CYS B 29  ? CYS B 336 ? 1_555 CYS B 361 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS B 47  ? CYS B 100 ? CYS B 379 ? 1_555 CYS B 432 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS B 59  ? CYS B 193 ? CYS B 391 ? 1_555 CYS B 525 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS B 148 ? CYS B 156 ? CYS B 480 ? 1_555 CYS B 488 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN B 22  ? ILE B 26  ? ASN B 354 ILE B 358 
AA1 2 ASN B 62  ? ARG B 71  ? ASN B 394 ARG B 403 
AA1 3 PRO B 175 ? GLU B 184 ? PRO B 507 GLU B 516 
AA1 4 CYS B 100 ? ASN B 105 ? CYS B 432 ASN B 437 
AA1 5 THR B 44  ? CYS B 47  ? THR B 376 CYS B 379 
AA2 1 CYS B 29  ? ALA B 31  ? CYS B 361 ALA B 363 
AA2 2 VAL B 192 ? GLY B 194 ? VAL B 524 GLY B 526 
AA2 3 CYS B 59  ? PHE B 60  ? CYS B 391 PHE B 392 
AA3 1 ARG B 120 ? ARG B 122 ? ARG B 452 ARG B 454 
AA3 2 LEU B 160 ? SER B 162 ? LEU B 492 SER B 494 
AA4 1 TYR B 141 ? GLN B 142 ? TYR B 473 GLN B 474 
AA4 2 CYS B 156 ? TYR B 157 ? CYS B 488 TYR B 489 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE B 26  ? N ILE B 358 O VAL B 63  ? O VAL B 395 
AA1 2 3 N ILE B 70  ? N ILE B 402 O TYR B 176 ? O TYR B 508 
AA1 3 4 O VAL B 179 ? O VAL B 511 N ILE B 102 ? N ILE B 434 
AA1 4 5 O VAL B 101 ? O VAL B 433 N LYS B 46  ? N LYS B 378 
AA2 1 2 N ALA B 31  ? N ALA B 363 O CYS B 193 ? O CYS B 525 
AA2 2 3 O VAL B 192 ? O VAL B 524 N PHE B 60  ? N PHE B 392 
AA3 1 2 N TYR B 121 ? N TYR B 453 O GLN B 161 ? O GLN B 493 
AA4 1 2 N TYR B 141 ? N TYR B 473 O TYR B 157 ? O TYR B 489 
# 
_pdbx_entry_details.entry_id                   8YDS 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA B 352 ? ? -116.60 53.22  
2 1 PHE B 377 ? ? -156.40 80.62  
3 1 ASN B 422 ? ? -129.89 -53.46 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     103 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   F 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B ASN 531 ? B ASN 199 
2  1 Y 1 B LEU 532 ? B LEU 200 
3  1 Y 1 B TYR 533 ? B TYR 201 
4  1 Y 1 B PHE 534 ? B PHE 202 
5  1 Y 1 B GLN 535 ? B GLN 203 
6  1 Y 1 B GLY 536 ? B GLY 204 
7  1 Y 1 B SER 537 ? B SER 205 
8  1 Y 1 B HIS 538 ? B HIS 206 
9  1 Y 1 B HIS 539 ? B HIS 207 
10 1 Y 1 B HIS 540 ? B HIS 208 
11 1 Y 1 B HIS 541 ? B HIS 209 
12 1 Y 1 B HIS 542 ? B HIS 210 
13 1 Y 1 B HIS 543 ? B HIS 211 
14 1 Y 1 B HIS 544 ? B HIS 212 
15 1 Y 1 B HIS 545 ? B HIS 213 
16 1 Y 1 B HIS 546 ? B HIS 214 
17 1 Y 1 B HIS 547 ? B HIS 215 
18 1 Y 1 B GLY 548 ? B GLY 216 
19 1 Y 1 B LEU 549 ? B LEU 217 
20 1 Y 1 B ASN 550 ? B ASN 218 
21 1 Y 1 B ASP 551 ? B ASP 219 
22 1 Y 1 B ILE 552 ? B ILE 220 
23 1 Y 1 B PHE 553 ? B PHE 221 
24 1 Y 1 B GLU 554 ? B GLU 222 
25 1 Y 1 B ALA 555 ? B ALA 223 
26 1 Y 1 B GLN 556 ? B GLN 224 
27 1 Y 1 B LYS 557 ? B LYS 225 
28 1 Y 1 B ILE 558 ? B ILE 226 
29 1 Y 1 B GLU 559 ? B GLU 227 
30 1 Y 1 B TRP 560 ? B TRP 228 
31 1 Y 1 B HIS 561 ? B HIS 229 
32 1 Y 1 B GLU 562 ? B GLU 230 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
NAG C1   C N R 264 
NAG C2   C N R 265 
NAG C3   C N R 266 
NAG C4   C N S 267 
NAG C5   C N R 268 
NAG C6   C N N 269 
NAG C7   C N N 270 
NAG C8   C N N 271 
NAG N2   N N N 272 
NAG O1   O N N 273 
NAG O3   O N N 274 
NAG O4   O N N 275 
NAG O5   O N N 276 
NAG O6   O N N 277 
NAG O7   O N N 278 
NAG H1   H N N 279 
NAG H2   H N N 280 
NAG H3   H N N 281 
NAG H4   H N N 282 
NAG H5   H N N 283 
NAG H61  H N N 284 
NAG H62  H N N 285 
NAG H81  H N N 286 
NAG H82  H N N 287 
NAG H83  H N N 288 
NAG HN2  H N N 289 
NAG HO1  H N N 290 
NAG HO3  H N N 291 
NAG HO4  H N N 292 
NAG HO6  H N N 293 
PHE N    N N N 294 
PHE CA   C N S 295 
PHE C    C N N 296 
PHE O    O N N 297 
PHE CB   C N N 298 
PHE CG   C Y N 299 
PHE CD1  C Y N 300 
PHE CD2  C Y N 301 
PHE CE1  C Y N 302 
PHE CE2  C Y N 303 
PHE CZ   C Y N 304 
PHE OXT  O N N 305 
PHE H    H N N 306 
PHE H2   H N N 307 
PHE HA   H N N 308 
PHE HB2  H N N 309 
PHE HB3  H N N 310 
PHE HD1  H N N 311 
PHE HD2  H N N 312 
PHE HE1  H N N 313 
PHE HE2  H N N 314 
PHE HZ   H N N 315 
PHE HXT  H N N 316 
PRO N    N N N 317 
PRO CA   C N S 318 
PRO C    C N N 319 
PRO O    O N N 320 
PRO CB   C N N 321 
PRO CG   C N N 322 
PRO CD   C N N 323 
PRO OXT  O N N 324 
PRO H    H N N 325 
PRO HA   H N N 326 
PRO HB2  H N N 327 
PRO HB3  H N N 328 
PRO HG2  H N N 329 
PRO HG3  H N N 330 
PRO HD2  H N N 331 
PRO HD3  H N N 332 
PRO HXT  H N N 333 
SER N    N N N 334 
SER CA   C N S 335 
SER C    C N N 336 
SER O    O N N 337 
SER CB   C N N 338 
SER OG   O N N 339 
SER OXT  O N N 340 
SER H    H N N 341 
SER H2   H N N 342 
SER HA   H N N 343 
SER HB2  H N N 344 
SER HB3  H N N 345 
SER HG   H N N 346 
SER HXT  H N N 347 
THR N    N N N 348 
THR CA   C N S 349 
THR C    C N N 350 
THR O    O N N 351 
THR CB   C N R 352 
THR OG1  O N N 353 
THR CG2  C N N 354 
THR OXT  O N N 355 
THR H    H N N 356 
THR H2   H N N 357 
THR HA   H N N 358 
THR HB   H N N 359 
THR HG1  H N N 360 
THR HG21 H N N 361 
THR HG22 H N N 362 
THR HG23 H N N 363 
THR HXT  H N N 364 
TRP N    N N N 365 
TRP CA   C N S 366 
TRP C    C N N 367 
TRP O    O N N 368 
TRP CB   C N N 369 
TRP CG   C Y N 370 
TRP CD1  C Y N 371 
TRP CD2  C Y N 372 
TRP NE1  N Y N 373 
TRP CE2  C Y N 374 
TRP CE3  C Y N 375 
TRP CZ2  C Y N 376 
TRP CZ3  C Y N 377 
TRP CH2  C Y N 378 
TRP OXT  O N N 379 
TRP H    H N N 380 
TRP H2   H N N 381 
TRP HA   H N N 382 
TRP HB2  H N N 383 
TRP HB3  H N N 384 
TRP HD1  H N N 385 
TRP HE1  H N N 386 
TRP HE3  H N N 387 
TRP HZ2  H N N 388 
TRP HZ3  H N N 389 
TRP HH2  H N N 390 
TRP HXT  H N N 391 
TYR N    N N N 392 
TYR CA   C N S 393 
TYR C    C N N 394 
TYR O    O N N 395 
TYR CB   C N N 396 
TYR CG   C Y N 397 
TYR CD1  C Y N 398 
TYR CD2  C Y N 399 
TYR CE1  C Y N 400 
TYR CE2  C Y N 401 
TYR CZ   C Y N 402 
TYR OH   O N N 403 
TYR OXT  O N N 404 
TYR H    H N N 405 
TYR H2   H N N 406 
TYR HA   H N N 407 
TYR HB2  H N N 408 
TYR HB3  H N N 409 
TYR HD1  H N N 410 
TYR HD2  H N N 411 
TYR HE1  H N N 412 
TYR HE2  H N N 413 
TYR HH   H N N 414 
TYR HXT  H N N 415 
VAL N    N N N 416 
VAL CA   C N S 417 
VAL C    C N N 418 
VAL O    O N N 419 
VAL CB   C N N 420 
VAL CG1  C N N 421 
VAL CG2  C N N 422 
VAL OXT  O N N 423 
VAL H    H N N 424 
VAL H2   H N N 425 
VAL HA   H N N 426 
VAL HB   H N N 427 
VAL HG11 H N N 428 
VAL HG12 H N N 429 
VAL HG13 H N N 430 
VAL HG21 H N N 431 
VAL HG22 H N N 432 
VAL HG23 H N N 433 
VAL HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
NAG C1  C2   sing N N 250 
NAG C1  O1   sing N N 251 
NAG C1  O5   sing N N 252 
NAG C1  H1   sing N N 253 
NAG C2  C3   sing N N 254 
NAG C2  N2   sing N N 255 
NAG C2  H2   sing N N 256 
NAG C3  C4   sing N N 257 
NAG C3  O3   sing N N 258 
NAG C3  H3   sing N N 259 
NAG C4  C5   sing N N 260 
NAG C4  O4   sing N N 261 
NAG C4  H4   sing N N 262 
NAG C5  C6   sing N N 263 
NAG C5  O5   sing N N 264 
NAG C5  H5   sing N N 265 
NAG C6  O6   sing N N 266 
NAG C6  H61  sing N N 267 
NAG C6  H62  sing N N 268 
NAG C7  C8   sing N N 269 
NAG C7  N2   sing N N 270 
NAG C7  O7   doub N N 271 
NAG C8  H81  sing N N 272 
NAG C8  H82  sing N N 273 
NAG C8  H83  sing N N 274 
NAG N2  HN2  sing N N 275 
NAG O1  HO1  sing N N 276 
NAG O3  HO3  sing N N 277 
NAG O4  HO4  sing N N 278 
NAG O6  HO6  sing N N 279 
PHE N   CA   sing N N 280 
PHE N   H    sing N N 281 
PHE N   H2   sing N N 282 
PHE CA  C    sing N N 283 
PHE CA  CB   sing N N 284 
PHE CA  HA   sing N N 285 
PHE C   O    doub N N 286 
PHE C   OXT  sing N N 287 
PHE CB  CG   sing N N 288 
PHE CB  HB2  sing N N 289 
PHE CB  HB3  sing N N 290 
PHE CG  CD1  doub Y N 291 
PHE CG  CD2  sing Y N 292 
PHE CD1 CE1  sing Y N 293 
PHE CD1 HD1  sing N N 294 
PHE CD2 CE2  doub Y N 295 
PHE CD2 HD2  sing N N 296 
PHE CE1 CZ   doub Y N 297 
PHE CE1 HE1  sing N N 298 
PHE CE2 CZ   sing Y N 299 
PHE CE2 HE2  sing N N 300 
PHE CZ  HZ   sing N N 301 
PHE OXT HXT  sing N N 302 
PRO N   CA   sing N N 303 
PRO N   CD   sing N N 304 
PRO N   H    sing N N 305 
PRO CA  C    sing N N 306 
PRO CA  CB   sing N N 307 
PRO CA  HA   sing N N 308 
PRO C   O    doub N N 309 
PRO C   OXT  sing N N 310 
PRO CB  CG   sing N N 311 
PRO CB  HB2  sing N N 312 
PRO CB  HB3  sing N N 313 
PRO CG  CD   sing N N 314 
PRO CG  HG2  sing N N 315 
PRO CG  HG3  sing N N 316 
PRO CD  HD2  sing N N 317 
PRO CD  HD3  sing N N 318 
PRO OXT HXT  sing N N 319 
SER N   CA   sing N N 320 
SER N   H    sing N N 321 
SER N   H2   sing N N 322 
SER CA  C    sing N N 323 
SER CA  CB   sing N N 324 
SER CA  HA   sing N N 325 
SER C   O    doub N N 326 
SER C   OXT  sing N N 327 
SER CB  OG   sing N N 328 
SER CB  HB2  sing N N 329 
SER CB  HB3  sing N N 330 
SER OG  HG   sing N N 331 
SER OXT HXT  sing N N 332 
THR N   CA   sing N N 333 
THR N   H    sing N N 334 
THR N   H2   sing N N 335 
THR CA  C    sing N N 336 
THR CA  CB   sing N N 337 
THR CA  HA   sing N N 338 
THR C   O    doub N N 339 
THR C   OXT  sing N N 340 
THR CB  OG1  sing N N 341 
THR CB  CG2  sing N N 342 
THR CB  HB   sing N N 343 
THR OG1 HG1  sing N N 344 
THR CG2 HG21 sing N N 345 
THR CG2 HG22 sing N N 346 
THR CG2 HG23 sing N N 347 
THR OXT HXT  sing N N 348 
TRP N   CA   sing N N 349 
TRP N   H    sing N N 350 
TRP N   H2   sing N N 351 
TRP CA  C    sing N N 352 
TRP CA  CB   sing N N 353 
TRP CA  HA   sing N N 354 
TRP C   O    doub N N 355 
TRP C   OXT  sing N N 356 
TRP CB  CG   sing N N 357 
TRP CB  HB2  sing N N 358 
TRP CB  HB3  sing N N 359 
TRP CG  CD1  doub Y N 360 
TRP CG  CD2  sing Y N 361 
TRP CD1 NE1  sing Y N 362 
TRP CD1 HD1  sing N N 363 
TRP CD2 CE2  doub Y N 364 
TRP CD2 CE3  sing Y N 365 
TRP NE1 CE2  sing Y N 366 
TRP NE1 HE1  sing N N 367 
TRP CE2 CZ2  sing Y N 368 
TRP CE3 CZ3  doub Y N 369 
TRP CE3 HE3  sing N N 370 
TRP CZ2 CH2  doub Y N 371 
TRP CZ2 HZ2  sing N N 372 
TRP CZ3 CH2  sing Y N 373 
TRP CZ3 HZ3  sing N N 374 
TRP CH2 HH2  sing N N 375 
TRP OXT HXT  sing N N 376 
TYR N   CA   sing N N 377 
TYR N   H    sing N N 378 
TYR N   H2   sing N N 379 
TYR CA  C    sing N N 380 
TYR CA  CB   sing N N 381 
TYR CA  HA   sing N N 382 
TYR C   O    doub N N 383 
TYR C   OXT  sing N N 384 
TYR CB  CG   sing N N 385 
TYR CB  HB2  sing N N 386 
TYR CB  HB3  sing N N 387 
TYR CG  CD1  doub Y N 388 
TYR CG  CD2  sing Y N 389 
TYR CD1 CE1  sing Y N 390 
TYR CD1 HD1  sing N N 391 
TYR CD2 CE2  doub Y N 392 
TYR CD2 HD2  sing N N 393 
TYR CE1 CZ   doub Y N 394 
TYR CE1 HE1  sing N N 395 
TYR CE2 CZ   sing Y N 396 
TYR CE2 HE2  sing N N 397 
TYR CZ  OH   sing N N 398 
TYR OH  HH   sing N N 399 
TYR OXT HXT  sing N N 400 
VAL N   CA   sing N N 401 
VAL N   H    sing N N 402 
VAL N   H2   sing N N 403 
VAL CA  C    sing N N 404 
VAL CA  CB   sing N N 405 
VAL CA  HA   sing N N 406 
VAL C   O    doub N N 407 
VAL C   OXT  sing N N 408 
VAL CB  CG1  sing N N 409 
VAL CB  CG2  sing N N 410 
VAL CB  HB   sing N N 411 
VAL CG1 HG11 sing N N 412 
VAL CG1 HG12 sing N N 413 
VAL CG1 HG13 sing N N 414 
VAL CG2 HG21 sing N N 415 
VAL CG2 HG22 sing N N 416 
VAL CG2 HG23 sing N N 417 
VAL OXT HXT  sing N N 418 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan 'JP21fk0108462, JP21fk0108585, JP21ae0121028, JP18ae0101046' 1 
'Japan Society for the Promotion of Science (JSPS)'        Japan 20H00451                                                     2 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 NAG 1 n 
3 NAG 2 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7jzu 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YDS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013504 
_atom_sites.fract_transf_matrix[1][2]   0.007797 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015594 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009901 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 1   ? -14.15022 3.61483  -16.91163 1.000 55.52225 ? 1   ASP A N   1 
ATOM   2    C CA  . ASP A 1 1   ? -15.10339 4.42699  -16.15710 1.000 48.93333 ? 1   ASP A CA  1 
ATOM   3    C C   . ASP A 1 1   ? -16.54454 4.02722  -16.47769 1.000 46.81542 ? 1   ASP A C   1 
ATOM   4    O O   . ASP A 1 1   ? -16.81624 3.36820  -17.48389 1.000 47.50121 ? 1   ASP A O   1 
ATOM   5    C CB  . ASP A 1 1   ? -14.89621 5.91241  -16.45781 1.000 46.36579 ? 1   ASP A CB  1 
ATOM   6    C CG  . ASP A 1 1   ? -15.13374 6.24774  -17.92346 1.000 46.86806 ? 1   ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 1   ? -16.31025 6.41938  -18.31778 1.000 39.37139 ? 1   ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 1   ? -14.14417 6.32772  -18.68481 1.000 52.20551 ? 1   ASP A OD2 1 
ATOM   9    N N   . LYS A 1 2   ? -17.47472 4.45195  -15.62718 1.000 44.13589 ? 2   LYS A N   1 
ATOM   10   C CA  . LYS A 1 2   ? -18.87719 4.11314  -15.79873 1.000 37.43202 ? 2   LYS A CA  1 
ATOM   11   C C   . LYS A 1 2   ? -19.68095 5.23809  -16.44194 1.000 27.24424 ? 2   LYS A C   1 
ATOM   12   O O   . LYS A 1 2   ? -20.91137 5.20319  -16.39856 1.000 28.54689 ? 2   LYS A O   1 
ATOM   13   C CB  . LYS A 1 2   ? -19.48020 3.73100  -14.44271 1.000 38.79252 ? 2   LYS A CB  1 
ATOM   14   C CG  . LYS A 1 2   ? -19.45030 4.84251  -13.38864 1.000 38.72224 ? 2   LYS A CG  1 
ATOM   15   C CD  . LYS A 1 2   ? -20.06479 4.39390  -12.05264 1.000 40.33969 ? 2   LYS A CD  1 
ATOM   16   C CE  . LYS A 1 2   ? -19.15258 3.42295  -11.29804 1.000 41.74979 ? 2   LYS A CE  1 
ATOM   17   N NZ  . LYS A 1 2   ? -19.81044 2.83521  -10.08975 1.000 33.55611 ? 2   LYS A NZ  1 
ATOM   18   N N   . GLU A 1 3   ? -19.01802 6.22540  -17.05338 1.000 28.06296 ? 3   GLU A N   1 
ATOM   19   C CA  . GLU A 1 3   ? -19.70432 7.47591  -17.37477 1.000 26.24006 ? 3   GLU A CA  1 
ATOM   20   C C   . GLU A 1 3   ? -20.78963 7.27070  -18.42144 1.000 26.60784 ? 3   GLU A C   1 
ATOM   21   O O   . GLU A 1 3   ? -21.92165 7.72588  -18.23650 1.000 23.48114 ? 3   GLU A O   1 
ATOM   22   C CB  . GLU A 1 3   ? -18.70667 8.53986  -17.83024 1.000 30.13446 ? 3   GLU A CB  1 
ATOM   23   C CG  . GLU A 1 3   ? -17.77957 8.99508  -16.70717 1.000 29.21129 ? 3   GLU A CG  1 
ATOM   24   C CD  . GLU A 1 3   ? -17.00654 10.26410 -17.02581 1.000 30.67001 ? 3   GLU A CD  1 
ATOM   25   O OE1 . GLU A 1 3   ? -17.09215 10.76384 -18.17197 1.000 33.05558 ? 3   GLU A OE1 1 
ATOM   26   O OE2 . GLU A 1 3   ? -16.30881 10.76000 -16.11377 1.000 31.73310 ? 3   GLU A OE2 1 
ATOM   27   N N   . TRP A 1 4   ? -20.46694 6.58957  -19.53213 1.000 24.75691 ? 4   TRP A N   1 
ATOM   28   C CA  . TRP A 1 4   ? -21.45376 6.40152  -20.59637 1.000 24.93062 ? 4   TRP A CA  1 
ATOM   29   C C   . TRP A 1 4   ? -22.64075 5.57081  -20.11070 1.000 20.89268 ? 4   TRP A C   1 
ATOM   30   O O   . TRP A 1 4   ? -23.80223 5.93281  -20.33321 1.000 22.14285 ? 4   TRP A O   1 
ATOM   31   C CB  . TRP A 1 4   ? -20.79662 5.75015  -21.82373 1.000 25.01962 ? 4   TRP A CB  1 
ATOM   32   C CG  . TRP A 1 4   ? -21.71351 5.63313  -23.00580 1.000 28.21171 ? 4   TRP A CG  1 
ATOM   33   C CD1 . TRP A 1 4   ? -21.86494 6.53710  -24.02172 1.000 29.94771 ? 4   TRP A CD1 1 
ATOM   34   C CD2 . TRP A 1 4   ? -22.62200 4.55645  -23.28931 1.000 28.65272 ? 4   TRP A CD2 1 
ATOM   35   N NE1 . TRP A 1 4   ? -22.80850 6.08793  -24.92097 1.000 25.03543 ? 4   TRP A NE1 1 
ATOM   36   C CE2 . TRP A 1 4   ? -23.28910 4.87645  -24.49111 1.000 27.89153 ? 4   TRP A CE2 1 
ATOM   37   C CE3 . TRP A 1 4   ? -22.93618 3.35428  -22.64111 1.000 26.63699 ? 4   TRP A CE3 1 
ATOM   38   C CZ2 . TRP A 1 4   ? -24.24676 4.03383  -25.06329 1.000 28.02053 ? 4   TRP A CZ2 1 
ATOM   39   C CZ3 . TRP A 1 4   ? -23.88850 2.51852  -23.21098 1.000 25.34739 ? 4   TRP A CZ3 1 
ATOM   40   C CH2 . TRP A 1 4   ? -24.53308 2.86458  -24.40995 1.000 27.83753 ? 4   TRP A CH2 1 
ATOM   41   N N   . ILE A 1 5   ? -22.37323 4.45184  -19.43640 1.000 22.39231 ? 5   ILE A N   1 
ATOM   42   C CA  . ILE A 1 5   ? -23.49478 3.60093  -19.05445 1.000 23.11972 ? 5   ILE A CA  1 
ATOM   43   C C   . ILE A 1 5   ? -24.30995 4.25117  -17.93828 1.000 21.05208 ? 5   ILE A C   1 
ATOM   44   O O   . ILE A 1 5   ? -25.53903 4.12048  -17.90667 1.000 21.62876 ? 5   ILE A O   1 
ATOM   45   C CB  . ILE A 1 5   ? -23.00729 2.18560  -18.67407 1.000 25.73774 ? 5   ILE A CB  1 
ATOM   46   C CG1 . ILE A 1 5   ? -24.19300 1.24320  -18.41482 1.000 23.02299 ? 5   ILE A CG1 1 
ATOM   47   C CG2 . ILE A 1 5   ? -22.10523 2.22403  -17.45724 1.000 24.31618 ? 5   ILE A CG2 1 
ATOM   48   C CD1 . ILE A 1 5   ? -25.22032 1.21475  -19.50596 1.000 21.84375 ? 5   ILE A CD1 1 
ATOM   49   N N   . LEU A 1 6   ? -23.66449 4.97289  -17.01596 1.000 20.63076 ? 6   LEU A N   1 
ATOM   50   C CA  . LEU A 1 6   ? -24.44833 5.67571  -15.99520 1.000 20.89978 ? 6   LEU A CA  1 
ATOM   51   C C   . LEU A 1 6   ? -25.40099 6.68069  -16.63479 1.000 19.81106 ? 6   LEU A C   1 
ATOM   52   O O   . LEU A 1 6   ? -26.57297 6.77721  -16.24457 1.000 20.59100 ? 6   LEU A O   1 
ATOM   53   C CB  . LEU A 1 6   ? -23.52640 6.37658  -14.99769 1.000 23.30787 ? 6   LEU A CB  1 
ATOM   54   C CG  . LEU A 1 6   ? -24.23220 7.19307  -13.90227 1.000 21.56475 ? 6   LEU A CG  1 
ATOM   55   C CD1 . LEU A 1 6   ? -25.22065 6.31506  -13.09798 1.000 18.36022 ? 6   LEU A CD1 1 
ATOM   56   C CD2 . LEU A 1 6   ? -23.19714 7.82165  -12.98386 1.000 24.42776 ? 6   LEU A CD2 1 
ATOM   57   N N   . GLN A 1 7   ? -24.92308 7.41917  -17.64360 1.000 19.33898 ? 7   GLN A N   1 
ATOM   58   C CA  . GLN A 1 7   ? -25.77613 8.39096  -18.31622 1.000 19.16799 ? 7   GLN A CA  1 
ATOM   59   C C   . GLN A 1 7   ? -26.95171 7.70959  -19.00124 1.000 24.46959 ? 7   GLN A C   1 
ATOM   60   O O   . GLN A 1 7   ? -28.09021 8.19376  -18.93378 1.000 21.51749 ? 7   GLN A O   1 
ATOM   61   C CB  . GLN A 1 7   ? -24.96531 9.19265  -19.33825 1.000 21.18590 ? 7   GLN A CB  1 
ATOM   62   C CG  . GLN A 1 7   ? -25.78668 10.24655 -20.07986 1.000 22.25270 ? 7   GLN A CG  1 
ATOM   63   C CD  . GLN A 1 7   ? -26.19289 11.39472 -19.16615 1.000 24.38411 ? 7   GLN A CD  1 
ATOM   64   O OE1 . GLN A 1 7   ? -25.56349 11.61838 -18.13603 1.000 23.30222 ? 7   GLN A OE1 1 
ATOM   65   N NE2 . GLN A 1 7   ? -27.24898 12.11737 -19.53835 1.000 24.20530 ? 7   GLN A NE2 1 
ATOM   66   N N   . LYS A 1 8   ? -26.69631 6.58557  -19.67767 1.000 20.65956 ? 8   LYS A N   1 
ATOM   67   C CA  . LYS A 1 8   ? -27.78303 5.89427  -20.36326 1.000 20.15386 ? 8   LYS A CA  1 
ATOM   68   C C   . LYS A 1 8   ? -28.81645 5.37299  -19.37219 1.000 17.51329 ? 8   LYS A C   1 
ATOM   69   O O   . LYS A 1 8   ? -30.02166 5.45203  -19.62628 1.000 23.27337 ? 8   LYS A O   1 
ATOM   70   C CB  . LYS A 1 8   ? -27.22310 4.75970  -21.22320 1.000 20.36826 ? 8   LYS A CB  1 
ATOM   71   C CG  . LYS A 1 8   ? -26.52261 5.25130  -22.49628 1.000 25.38812 ? 8   LYS A CG  1 
ATOM   72   C CD  . LYS A 1 8   ? -27.50299 6.00820  -23.38642 1.000 27.90521 ? 8   LYS A CD  1 
ATOM   73   C CE  . LYS A 1 8   ? -26.87070 6.38369  -24.72346 1.000 36.32540 ? 8   LYS A CE  1 
ATOM   74   N NZ  . LYS A 1 8   ? -27.79812 7.18925  -25.56825 1.000 43.74020 ? 8   LYS A NZ  1 
ATOM   75   N N   . ILE A 1 9   ? -28.36907 4.85678  -18.22777 1.000 19.33663 ? 9   ILE A N   1 
ATOM   76   C CA  . ILE A 1 9   ? -29.32443 4.34579  -17.24938 1.000 19.70178 ? 9   ILE A CA  1 
ATOM   77   C C   . ILE A 1 9   ? -30.11673 5.49270  -16.63365 1.000 22.95810 ? 9   ILE A C   1 
ATOM   78   O O   . ILE A 1 9   ? -31.33599 5.40016  -16.44800 1.000 22.78762 ? 9   ILE A O   1 
ATOM   79   C CB  . ILE A 1 9   ? -28.59491 3.52062  -16.18577 1.000 21.58582 ? 9   ILE A CB  1 
ATOM   80   C CG1 . ILE A 1 9   ? -28.02090 2.25277  -16.81964 1.000 21.62461 ? 9   ILE A CG1 1 
ATOM   81   C CG2 . ILE A 1 9   ? -29.52870 3.16090  -15.05679 1.000 25.34609 ? 9   ILE A CG2 1 
ATOM   82   C CD1 . ILE A 1 9   ? -27.00176 1.57914  -15.94152 1.000 28.50777 ? 9   ILE A CD1 1 
ATOM   83   N N   . TYR A 1 10  ? -29.43589 6.59164  -16.31468 1.000 21.51031 ? 10  TYR A N   1 
ATOM   84   C CA  . TYR A 1 10  ? -30.12684 7.80327  -15.88270 1.000 19.68699 ? 10  TYR A CA  1 
ATOM   85   C C   . TYR A 1 10  ? -31.19238 8.22667  -16.88956 1.000 22.21970 ? 10  TYR A C   1 
ATOM   86   O O   . TYR A 1 10  ? -32.33002 8.53586  -16.51626 1.000 20.25559 ? 10  TYR A O   1 
ATOM   87   C CB  . TYR A 1 10  ? -29.10842 8.93108  -15.67409 1.000 20.80160 ? 10  TYR A CB  1 
ATOM   88   C CG  . TYR A 1 10  ? -29.74953 10.19465 -15.15206 1.000 22.45499 ? 10  TYR A CG  1 
ATOM   89   C CD1 . TYR A 1 10  ? -30.02500 10.33096 -13.79684 1.000 21.22179 ? 10  TYR A CD1 1 
ATOM   90   C CD2 . TYR A 1 10  ? -30.11298 11.22562 -16.01006 1.000 22.75951 ? 10  TYR A CD2 1 
ATOM   91   C CE1 . TYR A 1 10  ? -30.63316 11.46450 -13.30254 1.000 23.59732 ? 10  TYR A CE1 1 
ATOM   92   C CE2 . TYR A 1 10  ? -30.72291 12.37475 -15.52452 1.000 24.21612 ? 10  TYR A CE2 1 
ATOM   93   C CZ  . TYR A 1 10  ? -30.97468 12.48340 -14.16978 1.000 24.11365 ? 10  TYR A CZ  1 
ATOM   94   O OH  . TYR A 1 10  ? -31.57575 13.61378 -13.65536 1.000 25.31283 ? 10  TYR A OH  1 
ATOM   95   N N   . GLU A 1 11  ? -30.83506 8.25395  -18.18180 1.000 20.59956 ? 11  GLU A N   1 
ATOM   96   C CA  . GLU A 1 11  ? -31.77827 8.69421  -19.20681 1.000 21.89885 ? 11  GLU A CA  1 
ATOM   97   C C   . GLU A 1 11  ? -32.97523 7.75678  -19.32271 1.000 23.04452 ? 11  GLU A C   1 
ATOM   98   O O   . GLU A 1 11  ? -34.09600 8.21394  -19.55342 1.000 24.22027 ? 11  GLU A O   1 
ATOM   99   C CB  . GLU A 1 11  ? -31.06141 8.83820  -20.55384 1.000 24.13538 ? 11  GLU A CB  1 
ATOM   100  C CG  . GLU A 1 11  ? -30.13048 10.05508 -20.57623 1.000 25.86900 ? 11  GLU A CG  1 
ATOM   101  C CD  . GLU A 1 11  ? -29.32630 10.19574 -21.85985 1.000 34.53393 ? 11  GLU A CD  1 
ATOM   102  O OE1 . GLU A 1 11  ? -29.29449 9.23755  -22.65969 1.000 36.57933 ? 11  GLU A OE1 1 
ATOM   103  O OE2 . GLU A 1 11  ? -28.71772 11.26878 -22.05860 1.000 32.83299 ? 11  GLU A OE2 1 
ATOM   104  N N   . ILE A 1 12  ? -32.77577 6.44636  -19.15565 1.000 24.07178 ? 12  ILE A N   1 
ATOM   105  C CA  . ILE A 1 12  ? -33.92367 5.53735  -19.18995 1.000 24.48502 ? 12  ILE A CA  1 
ATOM   106  C C   . ILE A 1 12  ? -34.83731 5.79140  -17.99979 1.000 25.92817 ? 12  ILE A C   1 
ATOM   107  O O   . ILE A 1 12  ? -36.06679 5.84093  -18.14340 1.000 25.72316 ? 12  ILE A O   1 
ATOM   108  C CB  . ILE A 1 12  ? -33.47758 4.06502  -19.22766 1.000 23.86378 ? 12  ILE A CB  1 
ATOM   109  C CG1 . ILE A 1 12  ? -32.90232 3.69694  -20.58682 1.000 29.56144 ? 12  ILE A CG1 1 
ATOM   110  C CG2 . ILE A 1 12  ? -34.66483 3.16461  -18.98771 1.000 28.51431 ? 12  ILE A CG2 1 
ATOM   111  C CD1 . ILE A 1 12  ? -32.76502 2.18281  -20.78250 1.000 28.98752 ? 12  ILE A CD1 1 
ATOM   112  N N   . MET A 1 13  ? -34.25135 5.93713  -16.80545 1.000 24.44590 ? 13  MET A N   1 
ATOM   113  C CA  . MET A 1 13  ? -35.04067 6.28363  -15.62289 1.000 23.49375 ? 13  MET A CA  1 
ATOM   114  C C   . MET A 1 13  ? -35.93225 7.49195  -15.88884 1.000 24.51818 ? 13  MET A C   1 
ATOM   115  O O   . MET A 1 13  ? -37.12813 7.47716  -15.58283 1.000 27.96325 ? 13  MET A O   1 
ATOM   116  C CB  . MET A 1 13  ? -34.12105 6.55734  -14.42433 1.000 20.32925 ? 13  MET A CB  1 
ATOM   117  C CG  . MET A 1 13  ? -34.89303 7.00342  -13.15978 1.000 24.59887 ? 13  MET A CG  1 
ATOM   118  S SD  . MET A 1 13  ? -33.85271 7.40588  -11.75776 1.000 22.14953 ? 13  MET A SD  1 
ATOM   119  C CE  . MET A 1 13  ? -33.00733 8.87715  -12.37744 1.000 19.64690 ? 13  MET A CE  1 
ATOM   120  N N   . ARG A 1 14  ? -35.36444 8.55594  -16.46199 1.000 26.03231 ? 14  ARG A N   1 
ATOM   121  C CA  . ARG A 1 14  ? -36.15505 9.75540  -16.72105 1.000 26.48772 ? 14  ARG A CA  1 
ATOM   122  C C   . ARG A 1 14  ? -37.19990 9.51161  -17.80487 1.000 34.42951 ? 14  ARG A C   1 
ATOM   123  O O   . ARG A 1 14  ? -38.32978 10.00025 -17.69738 1.000 35.20496 ? 14  ARG A O   1 
ATOM   124  C CB  . ARG A 1 14  ? -35.23711 10.91870 -17.10087 1.000 27.35516 ? 14  ARG A CB  1 
ATOM   125  C CG  . ARG A 1 14  ? -34.13921 11.15237 -16.07907 1.000 26.00897 ? 14  ARG A CG  1 
ATOM   126  C CD  . ARG A 1 14  ? -34.63247 12.00983 -14.92854 1.000 30.55180 ? 14  ARG A CD  1 
ATOM   127  N NE  . ARG A 1 14  ? -34.60122 13.41250 -15.31760 1.000 36.40741 ? 14  ARG A NE  1 
ATOM   128  C CZ  . ARG A 1 14  ? -34.85764 14.42365 -14.50259 1.000 37.89591 ? 14  ARG A CZ  1 
ATOM   129  N NH1 . ARG A 1 14  ? -35.22544 14.22201 -13.24517 1.000 34.11450 ? 14  ARG A NH1 1 
ATOM   130  N NH2 . ARG A 1 14  ? -34.73254 15.66698 -14.95856 1.000 37.22177 ? 14  ARG A NH2 1 
ATOM   131  N N   . ARG A 1 15  ? -36.85104 8.75567  -18.85366 1.000 31.13807 ? 15  ARG A N   1 
ATOM   132  C CA  . ARG A 1 15  ? -37.84164 8.46092  -19.88856 1.000 33.80194 ? 15  ARG A CA  1 
ATOM   133  C C   . ARG A 1 15  ? -38.96526 7.58651  -19.34229 1.000 33.19908 ? 15  ARG A C   1 
ATOM   134  O O   . ARG A 1 15  ? -40.14241 7.82363  -19.63294 1.000 39.81331 ? 15  ARG A O   1 
ATOM   135  C CB  . ARG A 1 15  ? -37.19103 7.77691  -21.09528 1.000 36.40295 ? 15  ARG A CB  1 
ATOM   136  C CG  . ARG A 1 15  ? -36.16144 8.60365  -21.87105 1.000 40.52118 ? 15  ARG A CG  1 
ATOM   137  C CD  . ARG A 1 15  ? -36.73131 9.87055  -22.53576 1.000 45.81210 ? 15  ARG A CD  1 
ATOM   138  N NE  . ARG A 1 15  ? -36.78291 11.02515 -21.63670 1.000 50.03304 ? 15  ARG A NE  1 
ATOM   139  C CZ  . ARG A 1 15  ? -35.72272 11.65522 -21.13986 1.000 47.37959 ? 15  ARG A CZ  1 
ATOM   140  N NH1 . ARG A 1 15  ? -34.48803 11.25370 -21.40365 1.000 42.79857 ? 15  ARG A NH1 1 
ATOM   141  N NH2 . ARG A 1 15  ? -35.90647 12.70740 -20.34354 1.000 47.92264 ? 15  ARG A NH2 1 
ATOM   142  N N   . LEU A 1 16  ? -38.62362 6.55805  -18.56921 1.000 31.81151 ? 16  LEU A N   1 
ATOM   143  C CA  . LEU A 1 16  ? -39.66294 5.70558  -18.00112 1.000 32.87393 ? 16  LEU A CA  1 
ATOM   144  C C   . LEU A 1 16  ? -40.65050 6.51036  -17.17216 1.000 40.49520 ? 16  LEU A C   1 
ATOM   145  O O   . LEU A 1 16  ? -41.84313 6.19038  -17.15457 1.000 47.89543 ? 16  LEU A O   1 
ATOM   146  C CB  . LEU A 1 16  ? -39.03734 4.59520  -17.16813 1.000 31.83679 ? 16  LEU A CB  1 
ATOM   147  C CG  . LEU A 1 16  ? -38.30017 3.54119  -17.97993 1.000 30.87832 ? 16  LEU A CG  1 
ATOM   148  C CD1 . LEU A 1 16  ? -37.59708 2.55879  -17.07215 1.000 29.24341 ? 16  LEU A CD1 1 
ATOM   149  C CD2 . LEU A 1 16  ? -39.27178 2.81068  -18.91728 1.000 37.58823 ? 16  LEU A CD2 1 
ATOM   150  N N   . ASP A 1 17  ? -40.18863 7.57533  -16.51007 1.000 42.05017 ? 17  ASP A N   1 
ATOM   151  C CA  . ASP A 1 17  ? -41.09702 8.41269  -15.73347 1.000 46.16079 ? 17  ASP A CA  1 
ATOM   152  C C   . ASP A 1 17  ? -42.01783 9.20388  -16.65300 1.000 49.16172 ? 17  ASP A C   1 
ATOM   153  O O   . ASP A 1 17  ? -43.24398 9.15622  -16.50608 1.000 49.52881 ? 17  ASP A O   1 
ATOM   154  C CB  . ASP A 1 17  ? -40.30336 9.35106  -14.81758 1.000 47.52992 ? 17  ASP A CB  1 
ATOM   155  C CG  . ASP A 1 17  ? -40.98664 9.58747  -13.46652 1.000 56.76663 ? 17  ASP A CG  1 
ATOM   156  O OD1 . ASP A 1 17  ? -42.17310 9.21171  -13.30250 1.000 55.43085 ? 17  ASP A OD1 1 
ATOM   157  O OD2 . ASP A 1 17  ? -40.32618 10.14551 -12.55724 1.000 55.79746 ? 17  ASP A OD2 1 
ATOM   158  N N   . GLU A 1 18  ? -41.44096 9.92738  -17.61928 1.000 48.16102 ? 18  GLU A N   1 
ATOM   159  C CA  . GLU A 1 18  ? -42.24304 10.72542 -18.54625 1.000 50.33500 ? 18  GLU A CA  1 
ATOM   160  C C   . GLU A 1 18  ? -43.30655 9.88485  -19.24459 1.000 46.26829 ? 18  GLU A C   1 
ATOM   161  O O   . GLU A 1 18  ? -44.41616 10.36239 -19.50284 1.000 52.72967 ? 18  GLU A O   1 
ATOM   162  C CB  . GLU A 1 18  ? -41.34051 11.39047 -19.58335 1.000 47.18538 ? 18  GLU A CB  1 
ATOM   163  C CG  . GLU A 1 18  ? -40.25544 12.25784 -18.99783 1.000 53.75511 ? 18  GLU A CG  1 
ATOM   164  C CD  . GLU A 1 18  ? -39.28935 12.75934 -20.05410 1.000 57.98799 ? 18  GLU A CD  1 
ATOM   165  O OE1 . GLU A 1 18  ? -39.36487 12.27282 -21.20646 1.000 56.50124 ? 18  GLU A OE1 1 
ATOM   166  O OE2 . GLU A 1 18  ? -38.45651 13.63882 -19.73307 1.000 62.87379 ? 18  GLU A OE2 1 
ATOM   167  N N   . GLU A 1 19  ? -42.98614 8.63360  -19.55966 1.000 45.43898 ? 19  GLU A N   1 
ATOM   168  C CA  . GLU A 1 19  ? -43.93725 7.70462  -20.15104 1.000 46.67902 ? 19  GLU A CA  1 
ATOM   169  C C   . GLU A 1 19  ? -44.82658 7.01857  -19.11652 1.000 51.71303 ? 19  GLU A C   1 
ATOM   170  O O   . GLU A 1 19  ? -45.44954 5.99795  -19.44504 1.000 51.59248 ? 19  GLU A O   1 
ATOM   171  C CB  . GLU A 1 19  ? -43.20095 6.64296  -20.96930 1.000 41.83492 ? 19  GLU A CB  1 
ATOM   172  C CG  . GLU A 1 19  ? -42.32186 7.20537  -22.06926 1.000 43.83683 ? 19  GLU A CG  1 
ATOM   173  C CD  . GLU A 1 19  ? -43.10002 8.03689  -23.07219 1.000 45.63256 ? 19  GLU A CD  1 
ATOM   174  O OE1 . GLU A 1 19  ? -44.31696 7.79519  -23.25642 1.000 42.17187 ? 19  GLU A OE1 1 
ATOM   175  O OE2 . GLU A 1 19  ? -42.48601 8.94000  -23.67526 1.000 46.90576 ? 19  GLU A OE2 1 
ATOM   176  N N   . GLY A 1 20  ? -44.89238 7.53689  -17.88877 1.000 54.67354 ? 20  GLY A N   1 
ATOM   177  C CA  . GLY A 1 20  ? -45.76410 6.97725  -16.87159 1.000 54.01370 ? 20  GLY A CA  1 
ATOM   178  C C   . GLY A 1 20  ? -45.39463 5.60033  -16.36498 1.000 52.29686 ? 20  GLY A C   1 
ATOM   179  O O   . GLY A 1 20  ? -46.17051 5.01268  -15.60491 1.000 56.63774 ? 20  GLY A O   1 
ATOM   180  N N   . HIS A 1 21  ? -44.24945 5.04553  -16.77001 1.000 50.12033 ? 21  HIS A N   1 
ATOM   181  C CA  . HIS A 1 21  ? -43.75630 3.80442  -16.17614 1.000 44.97591 ? 21  HIS A CA  1 
ATOM   182  C C   . HIS A 1 21  ? -43.13588 4.10882  -14.80528 1.000 45.90236 ? 21  HIS A C   1 
ATOM   183  O O   . HIS A 1 21  ? -41.95469 3.86798  -14.55531 1.000 41.14951 ? 21  HIS A O   1 
ATOM   184  C CB  . HIS A 1 21  ? -42.75785 3.11305  -17.09845 1.000 42.72957 ? 21  HIS A CB  1 
ATOM   185  C CG  . HIS A 1 21  ? -43.32080 2.71839  -18.43266 1.000 47.18747 ? 21  HIS A CG  1 
ATOM   186  N ND1 . HIS A 1 21  ? -43.95427 1.51240  -18.64831 1.000 45.85792 ? 21  HIS A ND1 1 
ATOM   187  C CD2 . HIS A 1 21  ? -43.32247 3.36023  -19.62531 1.000 45.81282 ? 21  HIS A CD2 1 
ATOM   188  C CE1 . HIS A 1 21  ? -44.33632 1.43524  -19.91160 1.000 44.12815 ? 21  HIS A CE1 1 
ATOM   189  N NE2 . HIS A 1 21  ? -43.96479 2.54348  -20.52610 1.000 46.13287 ? 21  HIS A NE2 1 
ATOM   190  N N   . GLY A 1 22  ? -43.98196 4.64214  -13.90983 1.000 45.83709 ? 22  GLY A N   1 
ATOM   191  C CA  . GLY A 1 22  ? -43.50040 5.15640  -12.63195 1.000 41.92659 ? 22  GLY A CA  1 
ATOM   192  C C   . GLY A 1 22  ? -42.79570 4.11386  -11.78517 1.000 36.13285 ? 22  GLY A C   1 
ATOM   193  O O   . GLY A 1 22  ? -41.78583 4.40579  -11.13897 1.000 35.09634 ? 22  GLY A O   1 
ATOM   194  N N   . GLU A 1 23  ? -43.30462 2.88092  -11.78789 1.000 37.00120 ? 23  GLU A N   1 
ATOM   195  C CA  . GLU A 1 23  ? -42.68416 1.81193  -11.01078 1.000 33.51856 ? 23  GLU A CA  1 
ATOM   196  C C   . GLU A 1 23  ? -41.41075 1.28723  -11.66767 1.000 35.80029 ? 23  GLU A C   1 
ATOM   197  O O   . GLU A 1 23  ? -40.45053 0.92584  -10.97318 1.000 30.62438 ? 23  GLU A O   1 
ATOM   198  C CB  . GLU A 1 23  ? -43.68915 0.68011  -10.80445 1.000 36.10803 ? 23  GLU A CB  1 
ATOM   199  C CG  . GLU A 1 23  ? -43.07978 -0.63645 -10.39664 1.000 36.36776 ? 23  GLU A CG  1 
ATOM   200  C CD  . GLU A 1 23  ? -44.12979 -1.62724 -9.94023  1.000 35.37633 ? 23  GLU A CD  1 
ATOM   201  O OE1 . GLU A 1 23  ? -45.21412 -1.18121 -9.51308  1.000 38.87190 ? 23  GLU A OE1 1 
ATOM   202  O OE2 . GLU A 1 23  ? -43.87489 -2.84611 -10.01252 1.000 39.78250 ? 23  GLU A OE2 1 
ATOM   203  N N   . ALA A 1 24  ? -41.38074 1.20835  -13.00170 1.000 35.07005 ? 24  ALA A N   1 
ATOM   204  C CA  . ALA A 1 24  ? -40.13846 0.83065  -13.67027 1.000 32.83479 ? 24  ALA A CA  1 
ATOM   205  C C   . ALA A 1 24  ? -39.04157 1.86502  -13.42055 1.000 22.49258 ? 24  ALA A C   1 
ATOM   206  O O   . ALA A 1 24  ? -37.86960 1.50993  -13.25407 1.000 26.93879 ? 24  ALA A O   1 
ATOM   207  C CB  . ALA A 1 24  ? -40.37189 0.65739  -15.17457 1.000 33.93060 ? 24  ALA A CB  1 
ATOM   208  N N   . SER A 1 25  ? -39.40350 3.14558  -13.40831 1.000 23.42579 ? 25  SER A N   1 
ATOM   209  C CA  . SER A 1 25  ? -38.42773 4.19001  -13.10625 1.000 26.98425 ? 25  SER A CA  1 
ATOM   210  C C   . SER A 1 25  ? -37.80711 3.99518  -11.72098 1.000 27.13630 ? 25  SER A C   1 
ATOM   211  O O   . SER A 1 25  ? -36.59438 4.17145  -11.53391 1.000 22.20982 ? 25  SER A O   1 
ATOM   212  C CB  . SER A 1 25  ? -39.10435 5.55169  -13.21498 1.000 29.69332 ? 25  SER A CB  1 
ATOM   213  O OG  . SER A 1 25  ? -38.22356 6.59823  -12.85560 1.000 35.13858 ? 25  SER A OG  1 
ATOM   214  N N   . LEU A 1 26  ? -38.62084 3.61756  -10.73932 1.000 26.43797 ? 26  LEU A N   1 
ATOM   215  C CA  . LEU A 1 26  ? -38.09344 3.38682  -9.39824  1.000 25.16474 ? 26  LEU A CA  1 
ATOM   216  C C   . LEU A 1 26  ? -37.15946 2.18359  -9.36516  1.000 25.92589 ? 26  LEU A C   1 
ATOM   217  O O   . LEU A 1 26  ? -36.17797 2.17523  -8.61389  1.000 20.71309 ? 26  LEU A O   1 
ATOM   218  C CB  . LEU A 1 26  ? -39.25347 3.21540  -8.42005  1.000 27.64395 ? 26  LEU A CB  1 
ATOM   219  C CG  . LEU A 1 26  ? -40.06936 4.48806  -8.18643  1.000 28.78398 ? 26  LEU A CG  1 
ATOM   220  C CD1 . LEU A 1 26  ? -41.34185 4.18090  -7.41033  1.000 26.82241 ? 26  LEU A CD1 1 
ATOM   221  C CD2 . LEU A 1 26  ? -39.21221 5.48386  -7.40474  1.000 22.83431 ? 26  LEU A CD2 1 
ATOM   222  N N   . ARG A 1 27  ? -37.42481 1.16001  -10.18268 1.000 25.73594 ? 27  ARG A N   1 
ATOM   223  C CA  . ARG A 1 27  ? -36.50150 0.03274  -10.21914 1.000 24.29454 ? 27  ARG A CA  1 
ATOM   224  C C   . ARG A 1 27  ? -35.15283 0.46202  -10.78902 1.000 20.59661 ? 27  ARG A C   1 
ATOM   225  O O   . ARG A 1 27  ? -34.09905 0.03177  -10.30716 1.000 21.96012 ? 27  ARG A O   1 
ATOM   226  C CB  . ARG A 1 27  ? -37.11074 -1.11951 -11.02681 1.000 29.17120 ? 27  ARG A CB  1 
ATOM   227  C CG  . ARG A 1 27  ? -36.92105 -2.49734 -10.40302 1.000 37.09646 ? 27  ARG A CG  1 
ATOM   228  C CD  . ARG A 1 27  ? -37.61077 -3.59692 -11.21631 1.000 37.43671 ? 27  ARG A CD  1 
ATOM   229  N NE  . ARG A 1 27  ? -39.04847 -3.64841 -10.97044 1.000 43.38507 ? 27  ARG A NE  1 
ATOM   230  C CZ  . ARG A 1 27  ? -39.62879 -4.50912 -10.14486 1.000 38.54578 ? 27  ARG A CZ  1 
ATOM   231  N NH1 . ARG A 1 27  ? -38.92794 -5.43457 -9.51245  1.000 40.56605 ? 27  ARG A NH1 1 
ATOM   232  N NH2 . ARG A 1 27  ? -40.94199 -4.43008 -9.93904  1.000 39.32539 ? 27  ARG A NH2 1 
ATOM   233  N N   . VAL A 1 28  ? -35.16778 1.33803  -11.79289 1.000 23.57993 ? 28  VAL A N   1 
ATOM   234  C CA  . VAL A 1 28  ? -33.91617 1.83524  -12.36017 1.000 20.21010 ? 28  VAL A CA  1 
ATOM   235  C C   . VAL A 1 28  ? -33.19755 2.74348  -11.36643 1.000 18.47240 ? 28  VAL A C   1 
ATOM   236  O O   . VAL A 1 28  ? -31.97129 2.68437  -11.22310 1.000 21.16708 ? 28  VAL A O   1 
ATOM   237  C CB  . VAL A 1 28  ? -34.19929 2.54819  -13.69417 1.000 22.96104 ? 28  VAL A CB  1 
ATOM   238  C CG1 . VAL A 1 28  ? -32.90838 3.10387  -14.28141 1.000 19.67327 ? 28  VAL A CG1 1 
ATOM   239  C CG2 . VAL A 1 28  ? -34.85605 1.57052  -14.67517 1.000 24.35346 ? 28  VAL A CG2 1 
ATOM   240  N N   . SER A 1 29  ? -33.95155 3.57706  -10.64800 1.000 20.81267 ? 29  SER A N   1 
ATOM   241  C CA  . SER A 1 29  ? -33.36015 4.39640  -9.58733  1.000 17.17753 ? 29  SER A CA  1 
ATOM   242  C C   . SER A 1 29  ? -32.60997 3.54588  -8.57219  1.000 20.27042 ? 29  SER A C   1 
ATOM   243  O O   . SER A 1 29  ? -31.49948 3.89360  -8.15448  1.000 17.57136 ? 29  SER A O   1 
ATOM   244  C CB  . SER A 1 29  ? -34.46155 5.19597  -8.89259  1.000 22.06143 ? 29  SER A CB  1 
ATOM   245  O OG  . SER A 1 29  ? -33.90746 6.09070  -7.95256  1.000 21.97346 ? 29  SER A OG  1 
ATOM   246  N N   . ASP A 1 30  ? -33.20827 2.43239  -8.14063  1.000 19.77254 ? 30  ASP A N   1 
ATOM   247  C CA  . ASP A 1 30  ? -32.51585 1.56130  -7.19533  1.000 20.09696 ? 30  ASP A CA  1 
ATOM   248  C C   . ASP A 1 30  ? -31.17910 1.09413  -7.75361  1.000 20.33885 ? 30  ASP A C   1 
ATOM   249  O O   . ASP A 1 30  ? -30.17854 1.05026  -7.03158  1.000 21.89765 ? 30  ASP A O   1 
ATOM   250  C CB  . ASP A 1 30  ? -33.39581 0.36618  -6.84276  1.000 21.77679 ? 30  ASP A CB  1 
ATOM   251  C CG  . ASP A 1 30  ? -34.56568 0.75782  -5.98414  1.000 26.08430 ? 30  ASP A CG  1 
ATOM   252  O OD1 . ASP A 1 30  ? -34.57651 1.91672  -5.49697  1.000 23.31192 ? 30  ASP A OD1 1 
ATOM   253  O OD2 . ASP A 1 30  ? -35.47732 -0.07316 -5.81119  1.000 25.53772 ? 30  ASP A OD2 1 
ATOM   254  N N   . LEU A 1 31  ? -31.14964 0.73915  -9.03904  1.000 22.63505 ? 31  LEU A N   1 
ATOM   255  C CA  . LEU A 1 31  ? -29.90522 0.30403  -9.66632  1.000 22.05316 ? 31  LEU A CA  1 
ATOM   256  C C   . LEU A 1 31  ? -28.86016 1.41566  -9.67504  1.000 19.82828 ? 31  LEU A C   1 
ATOM   257  O O   . LEU A 1 31  ? -27.67399 1.17528  -9.40049  1.000 19.99827 ? 31  LEU A O   1 
ATOM   258  C CB  . LEU A 1 31  ? -30.19143 -0.16569 -11.09313 1.000 24.12183 ? 31  LEU A CB  1 
ATOM   259  C CG  . LEU A 1 31  ? -28.93142 -0.61133 -11.83731 1.000 23.69649 ? 31  LEU A CG  1 
ATOM   260  C CD1 . LEU A 1 31  ? -28.15684 -1.63949 -11.00161 1.000 24.15865 ? 31  LEU A CD1 1 
ATOM   261  C CD2 . LEU A 1 31  ? -29.30343 -1.17534 -13.17965 1.000 25.77049 ? 31  LEU A CD2 1 
ATOM   262  N N   . ILE A 1 32  ? -29.27369 2.63477  -10.01898 1.000 19.63293 ? 32  ILE A N   1 
ATOM   263  C CA  . ILE A 1 32  ? -28.34514 3.76625  -9.99134  1.000 19.14226 ? 32  ILE A CA  1 
ATOM   264  C C   . ILE A 1 32  ? -27.70276 3.88565  -8.61928  1.000 21.23125 ? 32  ILE A C   1 
ATOM   265  O O   . ILE A 1 32  ? -26.48529 4.05862  -8.49441  1.000 20.07731 ? 32  ILE A O   1 
ATOM   266  C CB  . ILE A 1 32  ? -29.06796 5.06392  -10.39198 1.000 19.91784 ? 32  ILE A CB  1 
ATOM   267  C CG1 . ILE A 1 32  ? -29.35289 5.04432  -11.89795 1.000 21.98682 ? 32  ILE A CG1 1 
ATOM   268  C CG2 . ILE A 1 32  ? -28.22131 6.27595  -10.01605 1.000 19.22504 ? 32  ILE A CG2 1 
ATOM   269  C CD1 . ILE A 1 32  ? -30.48262 5.95813  -12.34407 1.000 21.68631 ? 32  ILE A CD1 1 
ATOM   270  N N   . TYR A 1 33  ? -28.51324 3.76887  -7.56418  1.000 20.63788 ? 33  TYR A N   1 
ATOM   271  C CA  . TYR A 1 33  ? -27.97123 3.84261  -6.21227  1.000 20.10648 ? 33  TYR A CA  1 
ATOM   272  C C   . TYR A 1 33  ? -26.92128 2.75706  -5.97614  1.000 24.67588 ? 33  TYR A C   1 
ATOM   273  O O   . TYR A 1 33  ? -25.80948 3.04766  -5.52110  1.000 22.01119 ? 33  TYR A O   1 
ATOM   274  C CB  . TYR A 1 33  ? -29.09882 3.74133  -5.17687  1.000 21.63556 ? 33  TYR A CB  1 
ATOM   275  C CG  . TYR A 1 33  ? -28.57145 3.45344  -3.78588  1.000 23.39909 ? 33  TYR A CG  1 
ATOM   276  C CD1 . TYR A 1 33  ? -28.03980 4.46668  -2.99237  1.000 20.36925 ? 33  TYR A CD1 1 
ATOM   277  C CD2 . TYR A 1 33  ? -28.58198 2.15883  -3.27823  1.000 21.51175 ? 33  TYR A CD2 1 
ATOM   278  C CE1 . TYR A 1 33  ? -27.52257 4.18789  -1.72955  1.000 22.17402 ? 33  TYR A CE1 1 
ATOM   279  C CE2 . TYR A 1 33  ? -28.06953 1.87155  -2.02995  1.000 24.33710 ? 33  TYR A CE2 1 
ATOM   280  C CZ  . TYR A 1 33  ? -27.54919 2.88351  -1.25351  1.000 21.68021 ? 33  TYR A CZ  1 
ATOM   281  O OH  . TYR A 1 33  ? -27.04702 2.57882  -0.00842  1.000 24.78438 ? 33  TYR A OH  1 
ATOM   282  N N   . GLU A 1 34  ? -27.25939 1.49344  -6.27463  1.000 23.94399 ? 34  GLU A N   1 
ATOM   283  C CA  . GLU A 1 34  ? -26.33077 0.39641  -5.99389  1.000 27.08431 ? 34  GLU A CA  1 
ATOM   284  C C   . GLU A 1 34  ? -25.07000 0.51868  -6.84005  1.000 23.55738 ? 34  GLU A C   1 
ATOM   285  O O   . GLU A 1 34  ? -23.94896 0.34303  -6.34266  1.000 25.07741 ? 34  GLU A O   1 
ATOM   286  C CB  . GLU A 1 34  ? -27.01371 -0.95484 -6.24787  1.000 26.64648 ? 34  GLU A CB  1 
ATOM   287  C CG  . GLU A 1 34  ? -28.35942 -1.15593 -5.50806  1.000 31.21642 ? 34  GLU A CG  1 
ATOM   288  C CD  . GLU A 1 34  ? -28.21224 -1.48772 -4.00758  1.000 44.52431 ? 34  GLU A CD  1 
ATOM   289  O OE1 . GLU A 1 34  ? -27.09177 -1.81068 -3.55196  1.000 49.86005 ? 34  GLU A OE1 1 
ATOM   290  O OE2 . GLU A 1 34  ? -29.22920 -1.43134 -3.27579  1.000 45.17071 ? 34  GLU A OE2 1 
ATOM   291  N N   . PHE A 1 35  ? -25.24575 0.82839  -8.12354  1.000 22.43747 ? 35  PHE A N   1 
ATOM   292  C CA  . PHE A 1 35  ? -24.12679 1.01275  -9.04266  1.000 23.47347 ? 35  PHE A CA  1 
ATOM   293  C C   . PHE A 1 35  ? -23.15177 2.06523  -8.52772  1.000 24.87242 ? 35  PHE A C   1 
ATOM   294  O O   . PHE A 1 35  ? -21.93166 1.86134  -8.53259  1.000 26.02736 ? 35  PHE A O   1 
ATOM   295  C CB  . PHE A 1 35  ? -24.68861 1.41673  -10.40735 1.000 21.09677 ? 35  PHE A CB  1 
ATOM   296  C CG  . PHE A 1 35  ? -23.68226 1.41827  -11.52820 1.000 27.44199 ? 35  PHE A CG  1 
ATOM   297  C CD1 . PHE A 1 35  ? -22.60142 0.54829  -11.52833 1.000 26.73973 ? 35  PHE A CD1 1 
ATOM   298  C CD2 . PHE A 1 35  ? -23.84742 2.28129  -12.60582 1.000 28.11483 ? 35  PHE A CD2 1 
ATOM   299  C CE1 . PHE A 1 35  ? -21.68787 0.54667  -12.58337 1.000 26.69071 ? 35  PHE A CE1 1 
ATOM   300  C CE2 . PHE A 1 35  ? -22.93393 2.28792  -13.66634 1.000 29.09741 ? 35  PHE A CE2 1 
ATOM   301  C CZ  . PHE A 1 35  ? -21.85259 1.41593  -13.64542 1.000 27.06450 ? 35  PHE A CZ  1 
ATOM   302  N N   . MET A 1 36  ? -23.66821 3.21099  -8.07980  1.000 24.33659 ? 36  MET A N   1 
ATOM   303  C CA  . MET A 1 36  ? -22.75691 4.27960  -7.69639  1.000 23.29343 ? 36  MET A CA  1 
ATOM   304  C C   . MET A 1 36  ? -22.03634 3.99566  -6.38491  1.000 27.66770 ? 36  MET A C   1 
ATOM   305  O O   . MET A 1 36  ? -20.98534 4.59413  -6.13172  1.000 35.25691 ? 36  MET A O   1 
ATOM   306  C CB  . MET A 1 36  ? -23.51614 5.59680  -7.65306  1.000 21.02413 ? 36  MET A CB  1 
ATOM   307  C CG  . MET A 1 36  ? -23.94704 5.98232  -9.07290  1.000 26.65807 ? 36  MET A CG  1 
ATOM   308  S SD  . MET A 1 36  ? -24.77933 7.55455  -9.23278  1.000 30.55390 ? 36  MET A SD  1 
ATOM   309  C CE  . MET A 1 36  ? -23.41569 8.63980  -8.77479  1.000 26.91828 ? 36  MET A CE  1 
ATOM   310  N N   . LYS A 1 37  ? -22.54712 3.07901  -5.56368  1.000 28.94751 ? 37  LYS A N   1 
ATOM   311  C CA  . LYS A 1 37  ? -21.82530 2.70185  -4.34730  1.000 29.43578 ? 37  LYS A CA  1 
ATOM   312  C C   . LYS A 1 37  ? -20.54440 1.92483  -4.63851  1.000 34.21267 ? 37  LYS A C   1 
ATOM   313  O O   . LYS A 1 37  ? -19.65861 1.87957  -3.78128  1.000 34.29673 ? 37  LYS A O   1 
ATOM   314  C CB  . LYS A 1 37  ? -22.73015 1.87772  -3.43366  1.000 30.64159 ? 37  LYS A CB  1 
ATOM   315  C CG  . LYS A 1 37  ? -23.71755 2.70603  -2.62385  1.000 31.25001 ? 37  LYS A CG  1 
ATOM   316  C CD  . LYS A 1 37  ? -23.00507 3.52288  -1.55589  1.000 32.65514 ? 37  LYS A CD  1 
ATOM   317  C CE  . LYS A 1 37  ? -23.98947 4.41213  -0.81296  1.000 29.94520 ? 37  LYS A CE  1 
ATOM   318  N NZ  . LYS A 1 37  ? -23.34834 5.20281  0.25708   1.000 30.16333 ? 37  LYS A NZ  1 
ATOM   319  N N   . ARG A 1 38  ? -20.42013 1.32809  -5.82477  1.000 32.79305 ? 38  ARG A N   1 
ATOM   320  C CA  . ARG A 1 38  ? -19.28083 0.48067  -6.15144  1.000 34.23692 ? 38  ARG A CA  1 
ATOM   321  C C   . ARG A 1 38  ? -18.08435 1.30204  -6.62315  1.000 44.87893 ? 38  ARG A C   1 
ATOM   322  O O   . ARG A 1 38  ? -18.22642 2.38468  -7.20066  1.000 43.56512 ? 38  ARG A O   1 
ATOM   323  C CB  . ARG A 1 38  ? -19.66544 -0.53132 -7.23191  1.000 34.83970 ? 38  ARG A CB  1 
ATOM   324  C CG  . ARG A 1 38  ? -20.80932 -1.43551 -6.82709  1.000 32.70479 ? 38  ARG A CG  1 
ATOM   325  C CD  . ARG A 1 38  ? -21.27121 -2.27819 -7.97836  1.000 35.71489 ? 38  ARG A CD  1 
ATOM   326  N NE  . ARG A 1 38  ? -20.17414 -3.03474 -8.56965  1.000 36.31823 ? 38  ARG A NE  1 
ATOM   327  C CZ  . ARG A 1 38  ? -19.75913 -4.21577 -8.13244  1.000 34.94809 ? 38  ARG A CZ  1 
ATOM   328  N NH1 . ARG A 1 38  ? -20.28966 -4.78078 -7.05656  1.000 35.33667 ? 38  ARG A NH1 1 
ATOM   329  N NH2 . ARG A 1 38  ? -18.79724 -4.85088 -8.80002  1.000 38.09887 ? 38  ARG A NH2 1 
ATOM   330  N N   . ASP A 1 39  ? -16.89489 0.75409  -6.38999  1.000 50.86345 ? 39  ASP A N   1 
ATOM   331  C CA  . ASP A 1 39  ? -15.63919 1.40816  -6.74246  1.000 57.45496 ? 39  ASP A CA  1 
ATOM   332  C C   . ASP A 1 39  ? -15.26541 1.17688  -8.20663  1.000 61.03401 ? 39  ASP A C   1 
ATOM   333  O O   . ASP A 1 39  ? -14.40005 1.86559  -8.75283  1.000 65.06094 ? 39  ASP A O   1 
ATOM   334  C CB  . ASP A 1 39  ? -14.52062 0.90516  -5.82601  1.000 62.07865 ? 39  ASP A CB  1 
ATOM   335  C CG  . ASP A 1 39  ? -14.90978 0.95074  -4.35658  1.000 64.56070 ? 39  ASP A CG  1 
ATOM   336  O OD1 . ASP A 1 39  ? -15.35644 2.02246  -3.89362  1.000 67.61736 ? 39  ASP A OD1 1 
ATOM   337  O OD2 . ASP A 1 39  ? -14.78709 -0.08717 -3.66854  1.000 66.84708 ? 39  ASP A OD2 1 
ATOM   338  O OXT . ASP A 1 39  ? -15.81461 0.29963  -8.87911  1.000 55.38057 ? 39  ASP A OXT 1 
ATOM   339  N N   . THR B 2 1   ? -51.89750 18.38376 31.96905  1.000 52.49017 ? 333 THR B N   1 
ATOM   340  C CA  . THR B 2 1   ? -53.29384 18.65673 31.63383  1.000 59.03899 ? 333 THR B CA  1 
ATOM   341  C C   . THR B 2 1   ? -53.59106 18.45073 30.14050  1.000 57.66193 ? 333 THR B C   1 
ATOM   342  O O   . THR B 2 1   ? -54.48164 17.67647 29.77714  1.000 58.81066 ? 333 THR B O   1 
ATOM   343  C CB  . THR B 2 1   ? -53.69340 20.09609 32.03682  1.000 61.75833 ? 333 THR B CB  1 
ATOM   344  O OG1 . THR B 2 1   ? -52.80842 21.03967 31.41870  1.000 63.76612 ? 333 THR B OG1 1 
ATOM   345  C CG2 . THR B 2 1   ? -53.62243 20.26223 33.54255  1.000 65.03936 ? 333 THR B CG2 1 
ATOM   346  N N   . ASN B 2 2   ? -52.84506 19.14641 29.28312  1.000 52.58466 ? 334 ASN B N   1 
ATOM   347  C CA  . ASN B 2 2   ? -53.04767 19.03302 27.84321  1.000 49.26057 ? 334 ASN B CA  1 
ATOM   348  C C   . ASN B 2 2   ? -52.73783 17.62248 27.34717  1.000 40.66312 ? 334 ASN B C   1 
ATOM   349  O O   . ASN B 2 2   ? -51.74239 17.00965 27.73810  1.000 37.06843 ? 334 ASN B O   1 
ATOM   350  C CB  . ASN B 2 2   ? -52.16519 20.04670 27.11228  1.000 50.91798 ? 334 ASN B CB  1 
ATOM   351  C CG  . ASN B 2 2   ? -52.85340 21.38962 26.91422  1.000 60.96186 ? 334 ASN B CG  1 
ATOM   352  O OD1 . ASN B 2 2   ? -54.01375 21.44924 26.50411  1.000 64.41601 ? 334 ASN B OD1 1 
ATOM   353  N ND2 . ASN B 2 2   ? -52.13987 22.47420 27.20702  1.000 61.91781 ? 334 ASN B ND2 1 
ATOM   354  N N   . LEU B 2 3   ? -53.60568 17.09713 26.48875  1.000 43.53928 ? 335 LEU B N   1 
ATOM   355  C CA  . LEU B 2 3   ? -53.28150 15.87867 25.76126  1.000 39.10944 ? 335 LEU B CA  1 
ATOM   356  C C   . LEU B 2 3   ? -52.36144 16.22180 24.59496  1.000 28.75907 ? 335 LEU B C   1 
ATOM   357  O O   . LEU B 2 3   ? -52.56224 17.22405 23.90685  1.000 33.81259 ? 335 LEU B O   1 
ATOM   358  C CB  . LEU B 2 3   ? -54.55041 15.19493 25.25050  1.000 39.21640 ? 335 LEU B CB  1 
ATOM   359  C CG  . LEU B 2 3   ? -55.25659 14.21843 26.18498  1.000 42.94049 ? 335 LEU B CG  1 
ATOM   360  C CD1 . LEU B 2 3   ? -56.55420 13.75482 25.54027  1.000 44.68954 ? 335 LEU B CD1 1 
ATOM   361  C CD2 . LEU B 2 3   ? -54.33839 13.03636 26.49014  1.000 40.31956 ? 335 LEU B CD2 1 
ATOM   362  N N   . CYS B 2 4   ? -51.35025 15.39629 24.38291  1.000 34.84272 ? 336 CYS B N   1 
ATOM   363  C CA  . CYS B 2 4   ? -50.37397 15.68993 23.33729  1.000 32.81747 ? 336 CYS B CA  1 
ATOM   364  C C   . CYS B 2 4   ? -51.04454 15.63279 21.97021  1.000 31.74318 ? 336 CYS B C   1 
ATOM   365  O O   . CYS B 2 4   ? -51.81461 14.70485 21.69806  1.000 30.58403 ? 336 CYS B O   1 
ATOM   366  C CB  . CYS B 2 4   ? -49.20092 14.71957 23.40233  1.000 34.59231 ? 336 CYS B CB  1 
ATOM   367  S SG  . CYS B 2 4   ? -48.22210 14.87180 24.92079  1.000 34.19824 ? 336 CYS B SG  1 
ATOM   368  N N   . PRO B 2 5   ? -50.79568 16.59747 21.10420  1.000 32.09892 ? 337 PRO B N   1 
ATOM   369  C CA  . PRO B 2 5   ? -51.51195 16.69539 19.82524  1.000 32.08567 ? 337 PRO B CA  1 
ATOM   370  C C   . PRO B 2 5   ? -50.91467 15.79483 18.74612  1.000 30.49640 ? 337 PRO B C   1 
ATOM   371  O O   . PRO B 2 5   ? -50.47779 16.25529 17.68886  1.000 33.22800 ? 337 PRO B O   1 
ATOM   372  C CB  . PRO B 2 5   ? -51.35970 18.18319 19.49106  1.000 33.81955 ? 337 PRO B CB  1 
ATOM   373  C CG  . PRO B 2 5   ? -49.98636 18.51057 20.02162  1.000 36.52321 ? 337 PRO B CG  1 
ATOM   374  C CD  . PRO B 2 5   ? -49.84010 17.70651 21.29112  1.000 33.27782 ? 337 PRO B CD  1 
ATOM   375  N N   . PHE B 2 6   ? -50.89211 14.48607 19.01407  1.000 30.98835 ? 338 PHE B N   1 
ATOM   376  C CA  . PHE B 2 6   ? -50.41259 13.53540 18.01293  1.000 31.81132 ? 338 PHE B CA  1 
ATOM   377  C C   . PHE B 2 6   ? -51.24444 13.57862 16.73888  1.000 33.37308 ? 338 PHE B C   1 
ATOM   378  O O   . PHE B 2 6   ? -50.73821 13.22458 15.66523  1.000 31.39432 ? 338 PHE B O   1 
ATOM   379  C CB  . PHE B 2 6   ? -50.41728 12.12037 18.58630  1.000 30.18205 ? 338 PHE B CB  1 
ATOM   380  C CG  . PHE B 2 6   ? -49.30758 11.86341 19.56314  1.000 31.20640 ? 338 PHE B CG  1 
ATOM   381  C CD1 . PHE B 2 6   ? -47.99163 12.14088 19.22363  1.000 31.07433 ? 338 PHE B CD1 1 
ATOM   382  C CD2 . PHE B 2 6   ? -49.57807 11.35928 20.82506  1.000 34.85107 ? 338 PHE B CD2 1 
ATOM   383  C CE1 . PHE B 2 6   ? -46.95871 11.90756 20.12183  1.000 33.74482 ? 338 PHE B CE1 1 
ATOM   384  C CE2 . PHE B 2 6   ? -48.55002 11.12500 21.72848  1.000 35.77292 ? 338 PHE B CE2 1 
ATOM   385  C CZ  . PHE B 2 6   ? -47.24298 11.40164 21.37673  1.000 32.22001 ? 338 PHE B CZ  1 
ATOM   386  N N   . GLY B 2 7   ? -52.49880 14.02472 16.83638  1.000 31.11712 ? 339 GLY B N   1 
ATOM   387  C CA  . GLY B 2 7   ? -53.35276 14.08511 15.66424  1.000 31.44004 ? 339 GLY B CA  1 
ATOM   388  C C   . GLY B 2 7   ? -52.83228 15.03501 14.60634  1.000 30.72319 ? 339 GLY B C   1 
ATOM   389  O O   . GLY B 2 7   ? -52.92140 14.75021 13.41026  1.000 31.61713 ? 339 GLY B O   1 
ATOM   390  N N   . GLU B 2 8   ? -52.27449 16.17434 15.03226  1.000 30.77865 ? 340 GLU B N   1 
ATOM   391  C CA  . GLU B 2 8   ? -51.70812 17.13358 14.08409  1.000 32.36448 ? 340 GLU B CA  1 
ATOM   392  C C   . GLU B 2 8   ? -50.61408 16.51234 13.22883  1.000 29.60769 ? 340 GLU B C   1 
ATOM   393  O O   . GLU B 2 8   ? -50.37543 16.96903 12.10729  1.000 31.81450 ? 340 GLU B O   1 
ATOM   394  C CB  . GLU B 2 8   ? -51.14572 18.34669 14.82327  1.000 35.48310 ? 340 GLU B CB  1 
ATOM   395  C CG  . GLU B 2 8   ? -52.20817 19.25477 15.40977  1.000 40.88348 ? 340 GLU B CG  1 
ATOM   396  C CD  . GLU B 2 8   ? -51.64591 20.22398 16.43650  1.000 47.29294 ? 340 GLU B CD  1 
ATOM   397  O OE1 . GLU B 2 8   ? -50.48888 20.67475 16.26820  1.000 46.56195 ? 340 GLU B OE1 1 
ATOM   398  O OE2 . GLU B 2 8   ? -52.36409 20.51808 17.42053  1.000 49.57420 ? 340 GLU B OE2 1 
ATOM   399  N N   . VAL B 2 9   ? -49.93545 15.48889 13.74271  1.000 27.92730 ? 341 VAL B N   1 
ATOM   400  C CA  . VAL B 2 9   ? -48.86435 14.81280 13.02136  1.000 27.55458 ? 341 VAL B CA  1 
ATOM   401  C C   . VAL B 2 9   ? -49.44255 13.66871 12.20390  1.000 26.50197 ? 341 VAL B C   1 
ATOM   402  O O   . VAL B 2 9   ? -49.31884 13.64370 10.97407  1.000 25.69363 ? 341 VAL B O   1 
ATOM   403  C CB  . VAL B 2 9   ? -47.78545 14.29334 13.98820  1.000 25.92355 ? 341 VAL B CB  1 
ATOM   404  C CG1 . VAL B 2 9   ? -46.77073 13.42714 13.23378  1.000 22.88731 ? 341 VAL B CG1 1 
ATOM   405  C CG2 . VAL B 2 9   ? -47.09556 15.45857 14.67058  1.000 28.49734 ? 341 VAL B CG2 1 
ATOM   406  N N   . PHE B 2 10  ? -50.06005 12.70581 12.88887  1.000 23.74958 ? 342 PHE B N   1 
ATOM   407  C CA  . PHE B 2 10  ? -50.50492 11.48480 12.22475  1.000 27.97196 ? 342 PHE B CA  1 
ATOM   408  C C   . PHE B 2 10  ? -51.62157 11.74364 11.22511  1.000 29.81932 ? 342 PHE B C   1 
ATOM   409  O O   . PHE B 2 10  ? -51.73248 11.02321 10.22483  1.000 28.63800 ? 342 PHE B O   1 
ATOM   410  C CB  . PHE B 2 10  ? -50.95707 10.46609 13.26523  1.000 22.13220 ? 342 PHE B CB  1 
ATOM   411  C CG  . PHE B 2 10  ? -49.82355 9.81243  13.98807  1.000 26.14417 ? 342 PHE B CG  1 
ATOM   412  C CD1 . PHE B 2 10  ? -49.18645 10.45977 15.03172  1.000 23.26063 ? 342 PHE B CD1 1 
ATOM   413  C CD2 . PHE B 2 10  ? -49.38220 8.55479  13.60965  1.000 21.39191 ? 342 PHE B CD2 1 
ATOM   414  C CE1 . PHE B 2 10  ? -48.12541 9.85484  15.69589  1.000 21.77111 ? 342 PHE B CE1 1 
ATOM   415  C CE2 . PHE B 2 10  ? -48.33814 7.94220  14.26471  1.000 21.86148 ? 342 PHE B CE2 1 
ATOM   416  C CZ  . PHE B 2 10  ? -47.70382 8.59711  15.31527  1.000 22.04436 ? 342 PHE B CZ  1 
ATOM   417  N N   . ASN B 2 11  ? -52.45114 12.76058 11.46566  1.000 28.91086 ? 343 ASN B N   1 
ATOM   418  C CA  . ASN B 2 11  ? -53.60156 13.03539 10.61626  1.000 31.67853 ? 343 ASN B CA  1 
ATOM   419  C C   . ASN B 2 11  ? -53.42353 14.26600 9.73672   1.000 33.20497 ? 343 ASN B C   1 
ATOM   420  O O   . ASN B 2 11  ? -54.40924 14.78105 9.20138   1.000 33.32724 ? 343 ASN B O   1 
ATOM   421  C CB  . ASN B 2 11  ? -54.85654 13.18380 11.46666  1.000 34.26946 ? 343 ASN B CB  1 
ATOM   422  C CG  . ASN B 2 11  ? -55.46866 11.86062 11.82055  1.000 34.63128 ? 343 ASN B CG  1 
ATOM   423  O OD1 . ASN B 2 11  ? -55.38216 10.89693 11.05880  1.000 35.68983 ? 343 ASN B OD1 1 
ATOM   424  N ND2 . ASN B 2 11  ? -56.09167 11.80000 12.99118  1.000 35.41408 ? 343 ASN B ND2 1 
ATOM   425  N N   . ALA B 2 12  ? -52.19512 14.74117 9.55909   1.000 28.95745 ? 344 ALA B N   1 
ATOM   426  C CA  . ALA B 2 12  ? -51.97254 15.86092 8.65525   1.000 26.99756 ? 344 ALA B CA  1 
ATOM   427  C C   . ALA B 2 12  ? -52.43517 15.50946 7.24584   1.000 29.28325 ? 344 ALA B C   1 
ATOM   428  O O   . ALA B 2 12  ? -52.28545 14.37329 6.79028   1.000 27.94744 ? 344 ALA B O   1 
ATOM   429  C CB  . ALA B 2 12  ? -50.49565 16.24763 8.64015   1.000 24.48494 ? 344 ALA B CB  1 
ATOM   430  N N   . THR B 2 13  ? -52.99706 16.50173 6.55316   1.000 29.62558 ? 345 THR B N   1 
ATOM   431  C CA  . THR B 2 13  ? -53.48855 16.28256 5.19499   1.000 29.96887 ? 345 THR B CA  1 
ATOM   432  C C   . THR B 2 13  ? -52.34860 15.94699 4.24521   1.000 29.90606 ? 345 THR B C   1 
ATOM   433  O O   . THR B 2 13  ? -52.45923 15.03505 3.41975   1.000 28.60570 ? 345 THR B O   1 
ATOM   434  C CB  . THR B 2 13  ? -54.23187 17.52368 4.70135   1.000 31.16304 ? 345 THR B CB  1 
ATOM   435  O OG1 . THR B 2 13  ? -55.22969 17.89318 5.66421   1.000 40.97215 ? 345 THR B OG1 1 
ATOM   436  C CG2 . THR B 2 13  ? -54.90282 17.24571 3.36539   1.000 32.96071 ? 345 THR B CG2 1 
ATOM   437  N N   . ARG B 2 14  ? -51.25311 16.68859 4.33701   1.000 28.91739 ? 346 ARG B N   1 
ATOM   438  C CA  . ARG B 2 14  ? -50.09456 16.50895 3.47762   1.000 27.34794 ? 346 ARG B CA  1 
ATOM   439  C C   . ARG B 2 14  ? -48.88081 16.17920 4.33391   1.000 26.50227 ? 346 ARG B C   1 
ATOM   440  O O   . ARG B 2 14  ? -48.70534 16.74932 5.41496   1.000 28.10985 ? 346 ARG B O   1 
ATOM   441  C CB  . ARG B 2 14  ? -49.84104 17.77236 2.65244   1.000 30.83739 ? 346 ARG B CB  1 
ATOM   442  C CG  . ARG B 2 14  ? -51.02856 18.13638 1.75606   1.000 34.84224 ? 346 ARG B CG  1 
ATOM   443  C CD  . ARG B 2 14  ? -50.80214 19.40310 0.92952   1.000 41.76467 ? 346 ARG B CD  1 
ATOM   444  N NE  . ARG B 2 14  ? -51.94638 19.67725 0.06159   1.000 51.94548 ? 346 ARG B NE  1 
ATOM   445  C CZ  . ARG B 2 14  ? -52.06975 19.26333 -1.19646  1.000 58.81379 ? 346 ARG B CZ  1 
ATOM   446  N NH1 . ARG B 2 14  ? -51.11798 18.56363 -1.79867  1.000 47.06868 ? 346 ARG B NH1 1 
ATOM   447  N NH2 . ARG B 2 14  ? -53.17631 19.56276 -1.87218  1.000 65.54243 ? 346 ARG B NH2 1 
ATOM   448  N N   . PHE B 2 15  ? -48.05491 15.24678 3.86095   1.000 21.27161 ? 347 PHE B N   1 
ATOM   449  C CA  . PHE B 2 15  ? -46.83418 14.86785 4.55854   1.000 19.31357 ? 347 PHE B CA  1 
ATOM   450  C C   . PHE B 2 15  ? -45.63704 15.45820 3.83044   1.000 21.84077 ? 347 PHE B C   1 
ATOM   451  O O   . PHE B 2 15  ? -45.71727 15.80540 2.64954   1.000 22.42845 ? 347 PHE B O   1 
ATOM   452  C CB  . PHE B 2 15  ? -46.68228 13.33745 4.64897   1.000 20.47367 ? 347 PHE B CB  1 
ATOM   453  C CG  . PHE B 2 15  ? -47.15038 12.74156 5.97026   1.000 20.19704 ? 347 PHE B CG  1 
ATOM   454  C CD1 . PHE B 2 15  ? -48.34746 13.13382 6.54401   1.000 20.71291 ? 347 PHE B CD1 1 
ATOM   455  C CD2 . PHE B 2 15  ? -46.40246 11.76680 6.61093   1.000 18.27008 ? 347 PHE B CD2 1 
ATOM   456  C CE1 . PHE B 2 15  ? -48.77842 12.57457 7.75072   1.000 23.38018 ? 347 PHE B CE1 1 
ATOM   457  C CE2 . PHE B 2 15  ? -46.82396 11.21508 7.81128   1.000 20.85367 ? 347 PHE B CE2 1 
ATOM   458  C CZ  . PHE B 2 15  ? -48.02603 11.62080 8.38077   1.000 21.12529 ? 347 PHE B CZ  1 
ATOM   459  N N   . ALA B 2 16  ? -44.51280 15.52525 4.53812   1.000 19.93437 ? 348 ALA B N   1 
ATOM   460  C CA  . ALA B 2 16  ? -43.28242 16.02753 3.94680   1.000 20.23621 ? 348 ALA B CA  1 
ATOM   461  C C   . ALA B 2 16  ? -42.65677 15.00007 3.00738   1.000 20.48798 ? 348 ALA B C   1 
ATOM   462  O O   . ALA B 2 16  ? -42.86379 13.79239 3.14208   1.000 17.57098 ? 348 ALA B O   1 
ATOM   463  C CB  . ALA B 2 16  ? -42.28034 16.39172 5.04344   1.000 20.64182 ? 348 ALA B CB  1 
ATOM   464  N N   . SER B 2 17  ? -41.89267 15.49635 2.03283   1.000 22.73160 ? 349 SER B N   1 
ATOM   465  C CA  . SER B 2 17  ? -40.98376 14.62685 1.29642   1.000 18.94753 ? 349 SER B CA  1 
ATOM   466  C C   . SER B 2 17  ? -39.85308 14.19980 2.21949   1.000 19.91555 ? 349 SER B C   1 
ATOM   467  O O   . SER B 2 17  ? -39.42627 14.95645 3.09394   1.000 17.29087 ? 349 SER B O   1 
ATOM   468  C CB  . SER B 2 17  ? -40.40205 15.34242 0.07321   1.000 19.40291 ? 349 SER B CB  1 
ATOM   469  O OG  . SER B 2 17  ? -41.35549 15.46923 -0.96239  1.000 17.82014 ? 349 SER B OG  1 
ATOM   470  N N   . VAL B 2 18  ? -39.34892 12.98502 1.99890   1.000 16.30571 ? 350 VAL B N   1 
ATOM   471  C CA  . VAL B 2 18  ? -38.38786 12.39437 2.92475   1.000 16.33739 ? 350 VAL B CA  1 
ATOM   472  C C   . VAL B 2 18  ? -37.08081 13.18285 2.94592   1.000 17.37673 ? 350 VAL B C   1 
ATOM   473  O O   . VAL B 2 18  ? -36.42906 13.28339 3.98794   1.000 16.45533 ? 350 VAL B O   1 
ATOM   474  C CB  . VAL B 2 18  ? -38.15851 10.90095 2.59168   1.000 17.16132 ? 350 VAL B CB  1 
ATOM   475  C CG1 . VAL B 2 18  ? -37.54229 10.71319 1.20107   1.000 14.01888 ? 350 VAL B CG1 1 
ATOM   476  C CG2 . VAL B 2 18  ? -37.29224 10.22840 3.68194   1.000 16.97076 ? 350 VAL B CG2 1 
ATOM   477  N N   . TYR B 2 19  ? -36.65318 13.73203 1.80190   1.000 19.80883 ? 351 TYR B N   1 
ATOM   478  C CA  . TYR B 2 19  ? -35.40871 14.50062 1.80331   1.000 17.17706 ? 351 TYR B CA  1 
ATOM   479  C C   . TYR B 2 19  ? -35.54131 15.75481 2.66206   1.000 17.86013 ? 351 TYR B C   1 
ATOM   480  O O   . TYR B 2 19  ? -34.55770 16.22314 3.25156   1.000 17.31722 ? 351 TYR B O   1 
ATOM   481  C CB  . TYR B 2 19  ? -35.00152 14.86541 0.37086   1.000 16.57374 ? 351 TYR B CB  1 
ATOM   482  C CG  . TYR B 2 19  ? -35.65709 16.10743 -0.19597  1.000 16.53897 ? 351 TYR B CG  1 
ATOM   483  C CD1 . TYR B 2 19  ? -36.88477 16.03830 -0.84174  1.000 18.22587 ? 351 TYR B CD1 1 
ATOM   484  C CD2 . TYR B 2 19  ? -35.02334 17.35506 -0.11756  1.000 16.78798 ? 351 TYR B CD2 1 
ATOM   485  C CE1 . TYR B 2 19  ? -37.47916 17.17503 -1.37686  1.000 19.08759 ? 351 TYR B CE1 1 
ATOM   486  C CE2 . TYR B 2 19  ? -35.60454 18.48990 -0.66065  1.000 17.26098 ? 351 TYR B CE2 1 
ATOM   487  C CZ  . TYR B 2 19  ? -36.82462 18.39372 -1.29277  1.000 19.30044 ? 351 TYR B CZ  1 
ATOM   488  O OH  . TYR B 2 19  ? -37.41723 19.51013 -1.83554  1.000 21.40150 ? 351 TYR B OH  1 
ATOM   489  N N   . ALA B 2 20  ? -36.74610 16.29190 2.76147   1.000 15.29997 ? 352 ALA B N   1 
ATOM   490  C CA  . ALA B 2 20  ? -36.98837 17.46599 3.58330   1.000 19.57257 ? 352 ALA B CA  1 
ATOM   491  C C   . ALA B 2 20  ? -37.94698 17.08449 4.69841   1.000 21.14551 ? 352 ALA B C   1 
ATOM   492  O O   . ALA B 2 20  ? -38.99104 17.71896 4.86907   1.000 20.32573 ? 352 ALA B O   1 
ATOM   493  C CB  . ALA B 2 20  ? -37.55380 18.60507 2.73430   1.000 16.16460 ? 352 ALA B CB  1 
ATOM   494  N N   . TRP B 2 21  ? -37.60695 16.03043 5.44036   1.000 18.97234 ? 353 TRP B N   1 
ATOM   495  C CA  . TRP B 2 21  ? -38.52790 15.48370 6.42307   1.000 17.09207 ? 353 TRP B CA  1 
ATOM   496  C C   . TRP B 2 21  ? -38.91438 16.53389 7.45684   1.000 22.98507 ? 353 TRP B C   1 
ATOM   497  O O   . TRP B 2 21  ? -38.13033 17.42769 7.78757   1.000 21.13186 ? 353 TRP B O   1 
ATOM   498  C CB  . TRP B 2 21  ? -37.90521 14.26297 7.09756   1.000 15.72759 ? 353 TRP B CB  1 
ATOM   499  C CG  . TRP B 2 21  ? -36.46102 14.39707 7.53315   1.000 15.91155 ? 353 TRP B CG  1 
ATOM   500  C CD1 . TRP B 2 21  ? -35.32848 14.19279 6.77416   1.000 17.73654 ? 353 TRP B CD1 1 
ATOM   501  C CD2 . TRP B 2 21  ? -36.01223 14.70039 8.84742   1.000 15.60333 ? 353 TRP B CD2 1 
ATOM   502  N NE1 . TRP B 2 21  ? -34.19587 14.37733 7.55135   1.000 17.82878 ? 353 TRP B NE1 1 
ATOM   503  C CE2 . TRP B 2 21  ? -34.59611 14.67502 8.83136   1.000 18.98981 ? 353 TRP B CE2 1 
ATOM   504  C CE3 . TRP B 2 21  ? -36.67362 14.99110 10.04998  1.000 19.05456 ? 353 TRP B CE3 1 
ATOM   505  C CZ2 . TRP B 2 21  ? -33.83428 14.93552 9.96873   1.000 18.64918 ? 353 TRP B CZ2 1 
ATOM   506  C CZ3 . TRP B 2 21  ? -35.91013 15.23851 11.18594  1.000 17.14783 ? 353 TRP B CZ3 1 
ATOM   507  C CH2 . TRP B 2 21  ? -34.50450 15.21220 11.13310  1.000 18.70858 ? 353 TRP B CH2 1 
ATOM   508  N N   . ASN B 2 22  ? -40.14441 16.42672 7.95441   1.000 18.14882 ? 354 ASN B N   1 
ATOM   509  C CA  . ASN B 2 22  ? -40.63855 17.35900 8.96211   1.000 19.23172 ? 354 ASN B CA  1 
ATOM   510  C C   . ASN B 2 22  ? -40.35640 16.84049 10.36295  1.000 20.70635 ? 354 ASN B C   1 
ATOM   511  O O   . ASN B 2 22  ? -40.39922 15.64010 10.61457  1.000 16.98882 ? 354 ASN B O   1 
ATOM   512  C CB  . ASN B 2 22  ? -42.13889 17.58689 8.80460   1.000 21.50847 ? 354 ASN B CB  1 
ATOM   513  C CG  . ASN B 2 22  ? -42.64779 18.71030 9.69011   1.000 34.38359 ? 354 ASN B CG  1 
ATOM   514  O OD1 . ASN B 2 22  ? -42.51596 19.88855 9.34683   1.000 39.67005 ? 354 ASN B OD1 1 
ATOM   515  N ND2 . ASN B 2 22  ? -43.21399 18.35422 10.84636  1.000 28.83123 ? 354 ASN B ND2 1 
ATOM   516  N N   . ARG B 2 23  ? -40.08561 17.76207 11.28873  1.000 22.06026 ? 355 ARG B N   1 
ATOM   517  C CA  . ARG B 2 23  ? -39.92807 17.40983 12.69585  1.000 20.24180 ? 355 ARG B CA  1 
ATOM   518  C C   . ARG B 2 23  ? -40.82773 18.30923 13.51910  1.000 22.14200 ? 355 ARG B C   1 
ATOM   519  O O   . ARG B 2 23  ? -40.79891 19.52693 13.34289  1.000 19.33553 ? 355 ARG B O   1 
ATOM   520  C CB  . ARG B 2 23  ? -38.48514 17.56396 13.18173  1.000 18.93790 ? 355 ARG B CB  1 
ATOM   521  C CG  . ARG B 2 23  ? -38.37443 17.50453 14.72735  1.000 23.40649 ? 355 ARG B CG  1 
ATOM   522  C CD  . ARG B 2 23  ? -36.94888 17.31646 15.20778  1.000 23.23447 ? 355 ARG B CD  1 
ATOM   523  N NE  . ARG B 2 23  ? -36.49917 15.94993 14.98952  1.000 19.25933 ? 355 ARG B NE  1 
ATOM   524  C CZ  . ARG B 2 23  ? -35.34667 15.45869 15.42123  1.000 23.84256 ? 355 ARG B CZ  1 
ATOM   525  N NH1 . ARG B 2 23  ? -34.52450 16.17602 16.16404  1.000 25.46092 ? 355 ARG B NH1 1 
ATOM   526  N NH2 . ARG B 2 23  ? -35.00743 14.21494 15.09507  1.000 23.37447 ? 355 ARG B NH2 1 
ATOM   527  N N   . LYS B 2 24  ? -41.60507 17.71114 14.42308  1.000 17.87524 ? 356 LYS B N   1 
ATOM   528  C CA  . LYS B 2 24  ? -42.47906 18.43644 15.33748  1.000 22.51670 ? 356 LYS B CA  1 
ATOM   529  C C   . LYS B 2 24  ? -42.03250 18.16637 16.76772  1.000 21.26136 ? 356 LYS B C   1 
ATOM   530  O O   . LYS B 2 24  ? -41.87939 17.00781 17.16627  1.000 19.35703 ? 356 LYS B O   1 
ATOM   531  C CB  . LYS B 2 24  ? -43.94261 18.01815 15.14271  1.000 23.45669 ? 356 LYS B CB  1 
ATOM   532  C CG  . LYS B 2 24  ? -44.89851 18.52399 16.22687  1.000 27.92793 ? 356 LYS B CG  1 
ATOM   533  C CD  . LYS B 2 24  ? -45.48111 19.86054 15.85585  1.000 32.98715 ? 356 LYS B CD  1 
ATOM   534  C CE  . LYS B 2 24  ? -46.55101 20.27495 16.85818  1.000 41.04898 ? 356 LYS B CE  1 
ATOM   535  N NZ  . LYS B 2 24  ? -46.55560 21.75157 17.00825  1.000 42.90191 ? 356 LYS B NZ  1 
ATOM   536  N N   . ARG B 2 25  ? -41.79122 19.22608 17.53302  1.000 18.54718 ? 357 ARG B N   1 
ATOM   537  C CA  . ARG B 2 25  ? -41.46724 19.05654 18.94680  1.000 17.85307 ? 357 ARG B CA  1 
ATOM   538  C C   . ARG B 2 25  ? -42.76435 18.97686 19.74538  1.000 19.51773 ? 357 ARG B C   1 
ATOM   539  O O   . ARG B 2 25  ? -43.62686 19.85399 19.63220  1.000 21.26709 ? 357 ARG B O   1 
ATOM   540  C CB  . ARG B 2 25  ? -40.59100 20.19874 19.47419  1.000 22.15423 ? 357 ARG B CB  1 
ATOM   541  C CG  . ARG B 2 25  ? -40.36466 20.10942 20.99273  1.000 20.64814 ? 357 ARG B CG  1 
ATOM   542  C CD  . ARG B 2 25  ? -39.27571 21.07350 21.47517  1.000 25.73065 ? 357 ARG B CD  1 
ATOM   543  N NE  . ARG B 2 25  ? -39.59651 22.46260 21.16714  1.000 26.78759 ? 357 ARG B NE  1 
ATOM   544  C CZ  . ARG B 2 25  ? -40.33050 23.25863 21.93525  1.000 32.65494 ? 357 ARG B CZ  1 
ATOM   545  N NH1 . ARG B 2 25  ? -40.87380 22.82723 23.06041  1.000 30.36675 ? 357 ARG B NH1 1 
ATOM   546  N NH2 . ARG B 2 25  ? -40.52361 24.52165 21.56285  1.000 34.81712 ? 357 ARG B NH2 1 
ATOM   547  N N   . ILE B 2 26  ? -42.90434 17.91755 20.53287  1.000 19.67108 ? 358 ILE B N   1 
ATOM   548  C CA  . ILE B 2 26  ? -44.06899 17.70766 21.38684  1.000 20.76857 ? 358 ILE B CA  1 
ATOM   549  C C   . ILE B 2 26  ? -43.59865 17.93887 22.81713  1.000 17.26150 ? 358 ILE B C   1 
ATOM   550  O O   . ILE B 2 26  ? -42.61798 17.32977 23.25171  1.000 18.70642 ? 358 ILE B O   1 
ATOM   551  C CB  . ILE B 2 26  ? -44.65989 16.29857 21.20547  1.000 20.15434 ? 358 ILE B CB  1 
ATOM   552  C CG1 . ILE B 2 26  ? -45.11993 16.08811 19.76000  1.000 20.75474 ? 358 ILE B CG1 1 
ATOM   553  C CG2 . ILE B 2 26  ? -45.79969 16.05527 22.17804  1.000 22.79260 ? 358 ILE B CG2 1 
ATOM   554  C CD1 . ILE B 2 26  ? -46.30277 16.94551 19.34399  1.000 24.67771 ? 358 ILE B CD1 1 
ATOM   555  N N   . SER B 2 27  ? -44.26445 18.85127 23.52899  1.000 20.69982 ? 359 SER B N   1 
ATOM   556  C CA  . SER B 2 27  ? -43.85006 19.23727 24.87284  1.000 21.86648 ? 359 SER B CA  1 
ATOM   557  C C   . SER B 2 27  ? -45.07129 19.65957 25.68117  1.000 20.35009 ? 359 SER B C   1 
ATOM   558  O O   . SER B 2 27  ? -46.09442 20.06616 25.12862  1.000 25.44147 ? 359 SER B O   1 
ATOM   559  C CB  . SER B 2 27  ? -42.83946 20.39442 24.84912  1.000 25.01946 ? 359 SER B CB  1 
ATOM   560  O OG  . SER B 2 27  ? -41.91509 20.24916 23.78710  1.000 30.78005 ? 359 SER B OG  1 
ATOM   561  N N   . ASN B 2 28  ? -44.94077 19.56621 27.00379  1.000 22.76811 ? 360 ASN B N   1 
ATOM   562  C CA  . ASN B 2 28  ? -45.91324 20.12464 27.94702  1.000 25.43366 ? 360 ASN B CA  1 
ATOM   563  C C   . ASN B 2 28  ? -47.30514 19.51896 27.75031  1.000 26.01677 ? 360 ASN B C   1 
ATOM   564  O O   . ASN B 2 28  ? -48.28844 20.22461 27.52898  1.000 28.09694 ? 360 ASN B O   1 
ATOM   565  C CB  . ASN B 2 28  ? -45.96389 21.64909 27.82789  1.000 26.70999 ? 360 ASN B CB  1 
ATOM   566  C CG  . ASN B 2 28  ? -44.62529 22.29073 28.10554  1.000 28.74962 ? 360 ASN B CG  1 
ATOM   567  O OD1 . ASN B 2 28  ? -44.02620 22.90508 27.22164  1.000 30.32806 ? 360 ASN B OD1 1 
ATOM   568  N ND2 . ASN B 2 28  ? -44.14605 22.15129 29.33584  1.000 24.33660 ? 360 ASN B ND2 1 
ATOM   569  N N   . CYS B 2 29  ? -47.37950 18.19484 27.85509  1.000 29.25414 ? 361 CYS B N   1 
ATOM   570  C CA  . CYS B 2 29  ? -48.65292 17.52831 27.59476  1.000 29.94601 ? 361 CYS B CA  1 
ATOM   571  C C   . CYS B 2 29  ? -48.60620 16.09972 28.12143  1.000 29.28176 ? 361 CYS B C   1 
ATOM   572  O O   . CYS B 2 29  ? -47.55120 15.59070 28.51175  1.000 28.15674 ? 361 CYS B O   1 
ATOM   573  C CB  . CYS B 2 29  ? -48.99420 17.55832 26.10099  1.000 33.10858 ? 361 CYS B CB  1 
ATOM   574  S SG  . CYS B 2 29  ? -47.71389 16.83708 25.03671  1.000 27.69592 ? 361 CYS B SG  1 
ATOM   575  N N   . VAL B 2 30  ? -49.78005 15.46114 28.13302  1.000 28.46362 ? 362 VAL B N   1 
ATOM   576  C CA  . VAL B 2 30  ? -49.94615 14.07670 28.56480  1.000 30.38203 ? 362 VAL B CA  1 
ATOM   577  C C   . VAL B 2 30  ? -50.17359 13.21354 27.32940  1.000 27.24012 ? 362 VAL B C   1 
ATOM   578  O O   . VAL B 2 30  ? -51.03870 13.52289 26.50323  1.000 33.94271 ? 362 VAL B O   1 
ATOM   579  C CB  . VAL B 2 30  ? -51.11952 13.92793 29.55205  1.000 31.55533 ? 362 VAL B CB  1 
ATOM   580  C CG1 . VAL B 2 30  ? -51.19585 12.49993 30.07076  1.000 32.28724 ? 362 VAL B CG1 1 
ATOM   581  C CG2 . VAL B 2 30  ? -50.96850 14.90379 30.70688  1.000 35.94641 ? 362 VAL B CG2 1 
ATOM   582  N N   . ALA B 2 31  ? -49.41612 12.12539 27.21646  1.000 32.71829 ? 363 ALA B N   1 
ATOM   583  C CA  . ALA B 2 31  ? -49.43771 11.26329 26.03672  1.000 38.43892 ? 363 ALA B CA  1 
ATOM   584  C C   . ALA B 2 31  ? -49.92116 9.86915  26.41408  1.000 33.51317 ? 363 ALA B C   1 
ATOM   585  O O   . ALA B 2 31  ? -49.33161 9.21787  27.28507  1.000 38.56677 ? 363 ALA B O   1 
ATOM   586  C CB  . ALA B 2 31  ? -48.04805 11.17318 25.40201  1.000 34.41656 ? 363 ALA B CB  1 
ATOM   587  N N   . ASP B 2 32  ? -50.96169 9.39847  25.73497  1.000 38.50829 ? 364 ASP B N   1 
ATOM   588  C CA  . ASP B 2 32  ? -51.42703 8.01746  25.87319  1.000 40.08118 ? 364 ASP B CA  1 
ATOM   589  C C   . ASP B 2 32  ? -50.91837 7.23637  24.66705  1.000 32.91115 ? 364 ASP B C   1 
ATOM   590  O O   . ASP B 2 32  ? -51.50330 7.30260  23.58635  1.000 32.07620 ? 364 ASP B O   1 
ATOM   591  C CB  . ASP B 2 32  ? -52.94749 7.94962  25.97683  1.000 38.65499 ? 364 ASP B CB  1 
ATOM   592  C CG  . ASP B 2 32  ? -53.42544 6.64346  26.58918  1.000 44.72261 ? 364 ASP B CG  1 
ATOM   593  O OD1 . ASP B 2 32  ? -52.83579 5.58106  26.27982  1.000 42.67351 ? 364 ASP B OD1 1 
ATOM   594  O OD2 . ASP B 2 32  ? -54.38244 6.67866  27.39152  1.000 58.56379 ? 364 ASP B OD2 1 
ATOM   595  N N   . TYR B 2 33  ? -49.82462 6.48964  24.85800  1.000 35.26198 ? 365 TYR B N   1 
ATOM   596  C CA  . TYR B 2 33  ? -49.19622 5.78261  23.74470  1.000 33.59375 ? 365 TYR B CA  1 
ATOM   597  C C   . TYR B 2 33  ? -49.95127 4.51633  23.35841  1.000 36.73702 ? 365 TYR B C   1 
ATOM   598  O O   . TYR B 2 33  ? -49.87670 4.08849  22.19583  1.000 31.80161 ? 365 TYR B O   1 
ATOM   599  C CB  . TYR B 2 33  ? -47.74626 5.44296  24.08662  1.000 34.97986 ? 365 TYR B CB  1 
ATOM   600  C CG  . TYR B 2 33  ? -46.89664 6.66981  24.34995  1.000 37.48224 ? 365 TYR B CG  1 
ATOM   601  C CD1 . TYR B 2 33  ? -46.52577 7.52282  23.31100  1.000 35.05720 ? 365 TYR B CD1 1 
ATOM   602  C CD2 . TYR B 2 33  ? -46.47308 6.98005  25.63811  1.000 39.67968 ? 365 TYR B CD2 1 
ATOM   603  C CE1 . TYR B 2 33  ? -45.75252 8.65378  23.54811  1.000 36.62852 ? 365 TYR B CE1 1 
ATOM   604  C CE2 . TYR B 2 33  ? -45.69864 8.10379  25.88655  1.000 36.30184 ? 365 TYR B CE2 1 
ATOM   605  C CZ  . TYR B 2 33  ? -45.34393 8.93605  24.83709  1.000 35.51447 ? 365 TYR B CZ  1 
ATOM   606  O OH  . TYR B 2 33  ? -44.57627 10.04457 25.09055  1.000 35.86155 ? 365 TYR B OH  1 
ATOM   607  N N   . SER B 2 34  ? -50.66127 3.89702  24.30964  1.000 36.09561 ? 366 SER B N   1 
ATOM   608  C CA  . SER B 2 34  ? -51.49756 2.74814  23.97003  1.000 34.77756 ? 366 SER B CA  1 
ATOM   609  C C   . SER B 2 34  ? -52.66356 3.16664  23.08371  1.000 34.96063 ? 366 SER B C   1 
ATOM   610  O O   . SER B 2 34  ? -53.02259 2.45442  22.13717  1.000 34.79688 ? 366 SER B O   1 
ATOM   611  C CB  . SER B 2 34  ? -52.01291 2.06845  25.23899  1.000 36.30988 ? 366 SER B CB  1 
ATOM   612  O OG  . SER B 2 34  ? -50.95864 1.46034  25.95767  1.000 44.30299 ? 366 SER B OG  1 
ATOM   613  N N   . VAL B 2 35  ? -53.26220 4.32320  23.36856  1.000 32.15750 ? 367 VAL B N   1 
ATOM   614  C CA  . VAL B 2 35  ? -54.32868 4.83331  22.51734  1.000 29.00460 ? 367 VAL B CA  1 
ATOM   615  C C   . VAL B 2 35  ? -53.79441 5.17502  21.13002  1.000 34.30930 ? 367 VAL B C   1 
ATOM   616  O O   . VAL B 2 35  ? -54.47042 4.95829  20.11693  1.000 35.43225 ? 367 VAL B O   1 
ATOM   617  C CB  . VAL B 2 35  ? -54.99885 6.04465  23.18693  1.000 38.50447 ? 367 VAL B CB  1 
ATOM   618  C CG1 . VAL B 2 35  ? -55.89641 6.76957  22.20076  1.000 34.23522 ? 367 VAL B CG1 1 
ATOM   619  C CG2 . VAL B 2 35  ? -55.78486 5.58458  24.42900  1.000 35.92321 ? 367 VAL B CG2 1 
ATOM   620  N N   . LEU B 2 36  ? -52.57767 5.71224  21.05663  1.000 31.63537 ? 368 LEU B N   1 
ATOM   621  C CA  . LEU B 2 36  ? -51.97123 5.97480  19.75303  1.000 29.59736 ? 368 LEU B CA  1 
ATOM   622  C C   . LEU B 2 36  ? -51.78178 4.67944  18.97842  1.000 25.85026 ? 368 LEU B C   1 
ATOM   623  O O   . LEU B 2 36  ? -52.11799 4.59100  17.79137  1.000 32.59926 ? 368 LEU B O   1 
ATOM   624  C CB  . LEU B 2 36  ? -50.62872 6.68622  19.93345  1.000 26.75091 ? 368 LEU B CB  1 
ATOM   625  C CG  . LEU B 2 36  ? -49.87451 6.91758  18.62150  1.000 25.59488 ? 368 LEU B CG  1 
ATOM   626  C CD1 . LEU B 2 36  ? -50.69440 7.80257  17.72252  1.000 27.43554 ? 368 LEU B CD1 1 
ATOM   627  C CD2 . LEU B 2 36  ? -48.49961 7.52602  18.89207  1.000 24.55521 ? 368 LEU B CD2 1 
ATOM   628  N N   . TYR B 2 37  ? -51.24294 3.66197  19.65370  1.000 28.73993 ? 369 TYR B N   1 
ATOM   629  C CA  . TYR B 2 37  ? -50.99534 2.36148  19.04671  1.000 28.87474 ? 369 TYR B CA  1 
ATOM   630  C C   . TYR B 2 37  ? -52.26865 1.77457  18.45175  1.000 33.48972 ? 369 TYR B C   1 
ATOM   631  O O   . TYR B 2 37  ? -52.23612 1.12510  17.40043  1.000 31.52090 ? 369 TYR B O   1 
ATOM   632  C CB  . TYR B 2 37  ? -50.40714 1.44943  20.11810  1.000 29.42503 ? 369 TYR B CB  1 
ATOM   633  C CG  . TYR B 2 37  ? -49.97608 0.06924  19.69285  1.000 34.78793 ? 369 TYR B CG  1 
ATOM   634  C CD1 . TYR B 2 37  ? -49.12515 -0.12677 18.61115  1.000 33.35294 ? 369 TYR B CD1 1 
ATOM   635  C CD2 . TYR B 2 37  ? -50.37205 -1.03804 20.41970  1.000 37.50712 ? 369 TYR B CD2 1 
ATOM   636  C CE1 . TYR B 2 37  ? -48.71357 -1.39927 18.24775  1.000 31.15873 ? 369 TYR B CE1 1 
ATOM   637  C CE2 . TYR B 2 37  ? -49.96577 -2.30647 20.06915  1.000 40.33323 ? 369 TYR B CE2 1 
ATOM   638  C CZ  . TYR B 2 37  ? -49.14154 -2.48302 18.98086  1.000 36.63190 ? 369 TYR B CZ  1 
ATOM   639  O OH  . TYR B 2 37  ? -48.74727 -3.75636 18.64779  1.000 33.76148 ? 369 TYR B OH  1 
ATOM   640  N N   . ASN B 2 38  ? -53.40421 2.01090  19.10184  1.000 34.96902 ? 370 ASN B N   1 
ATOM   641  C CA  . ASN B 2 38  ? -54.68625 1.47542  18.66883  1.000 36.69872 ? 370 ASN B CA  1 
ATOM   642  C C   . ASN B 2 38  ? -55.47361 2.43024  17.78770  1.000 34.68002 ? 370 ASN B C   1 
ATOM   643  O O   . ASN B 2 38  ? -56.58784 2.09245  17.37514  1.000 38.58129 ? 370 ASN B O   1 
ATOM   644  C CB  . ASN B 2 38  ? -55.52225 1.10404  19.89378  1.000 34.64738 ? 370 ASN B CB  1 
ATOM   645  C CG  . ASN B 2 38  ? -55.03805 -0.15517 20.54615  1.000 35.23144 ? 370 ASN B CG  1 
ATOM   646  O OD1 . ASN B 2 38  ? -55.29677 -1.24631 20.04964  1.000 37.55766 ? 370 ASN B OD1 1 
ATOM   647  N ND2 . ASN B 2 38  ? -54.32672 -0.02318 21.65440  1.000 38.10649 ? 370 ASN B ND2 1 
ATOM   648  N N   . SER B 2 39  ? -54.92891 3.60506  17.47996  1.000 33.38982 ? 371 SER B N   1 
ATOM   649  C CA  . SER B 2 39  ? -55.72796 4.63540  16.83108  1.000 33.71187 ? 371 SER B CA  1 
ATOM   650  C C   . SER B 2 39  ? -55.98398 4.36377  15.35336  1.000 36.93639 ? 371 SER B C   1 
ATOM   651  O O   . SER B 2 39  ? -56.83979 5.03138  14.76514  1.000 36.40595 ? 371 SER B O   1 
ATOM   652  C CB  . SER B 2 39  ? -55.04626 5.99566  16.99016  1.000 37.68804 ? 371 SER B CB  1 
ATOM   653  O OG  . SER B 2 39  ? -53.82874 6.04082  16.26089  1.000 37.27545 ? 371 SER B OG  1 
ATOM   654  N N   . ALA B 2 40  ? -55.27547 3.42159  14.73912  1.000 35.73728 ? 372 ALA B N   1 
ATOM   655  C CA  . ALA B 2 40  ? -55.43774 3.15878  13.31339  1.000 34.30883 ? 372 ALA B CA  1 
ATOM   656  C C   . ALA B 2 40  ? -54.75451 1.84268  12.98109  1.000 27.84272 ? 372 ALA B C   1 
ATOM   657  O O   . ALA B 2 40  ? -54.07841 1.23746  13.81641  1.000 30.70993 ? 372 ALA B O   1 
ATOM   658  C CB  . ALA B 2 40  ? -54.86755 4.29097  12.44944  1.000 32.75547 ? 372 ALA B CB  1 
ATOM   659  N N   . SER B 2 41  ? -54.93947 1.40700  11.74149  1.000 32.72888 ? 373 SER B N   1 
ATOM   660  C CA  . SER B 2 41  ? -54.29040 0.20115  11.25009  1.000 27.79731 ? 373 SER B CA  1 
ATOM   661  C C   . SER B 2 41  ? -52.90857 0.58497  10.72676  1.000 26.98314 ? 373 SER B C   1 
ATOM   662  O O   . SER B 2 41  ? -52.78738 1.30124  9.72597   1.000 30.16103 ? 373 SER B O   1 
ATOM   663  C CB  . SER B 2 41  ? -55.14372 -0.45461 10.16919  1.000 33.21140 ? 373 SER B CB  1 
ATOM   664  O OG  . SER B 2 41  ? -54.49586 -1.60890 9.66504   1.000 41.44450 ? 373 SER B OG  1 
ATOM   665  N N   . PHE B 2 42  ? -51.86975 0.11897  11.40680  1.000 27.81246 ? 374 PHE B N   1 
ATOM   666  C CA  . PHE B 2 42  ? -50.48991 0.41755  11.05557  1.000 24.96453 ? 374 PHE B CA  1 
ATOM   667  C C   . PHE B 2 42  ? -49.83292 -0.81410 10.45119  1.000 27.06595 ? 374 PHE B C   1 
ATOM   668  O O   . PHE B 2 42  ? -50.06908 -1.93465 10.90481  1.000 24.47838 ? 374 PHE B O   1 
ATOM   669  C CB  . PHE B 2 42  ? -49.70499 0.87507  12.29614  1.000 22.01540 ? 374 PHE B CB  1 
ATOM   670  C CG  . PHE B 2 42  ? -50.21977 2.15327  12.88761  1.000 25.20655 ? 374 PHE B CG  1 
ATOM   671  C CD1 . PHE B 2 42  ? -50.12896 3.34006  12.17108  1.000 19.25969 ? 374 PHE B CD1 1 
ATOM   672  C CD2 . PHE B 2 42  ? -50.82206 2.17106  14.13999  1.000 26.56131 ? 374 PHE B CD2 1 
ATOM   673  C CE1 . PHE B 2 42  ? -50.60786 4.52457  12.69165  1.000 20.09841 ? 374 PHE B CE1 1 
ATOM   674  C CE2 . PHE B 2 42  ? -51.30543 3.36141  14.67304  1.000 26.13674 ? 374 PHE B CE2 1 
ATOM   675  C CZ  . PHE B 2 42  ? -51.19470 4.53838  13.95171  1.000 24.12663 ? 374 PHE B CZ  1 
ATOM   676  N N   . SER B 2 43  ? -49.00110 -0.60271 9.43230   1.000 22.04766 ? 375 SER B N   1 
ATOM   677  C CA  . SER B 2 43  ? -48.21648 -1.68460 8.84584   1.000 22.41711 ? 375 SER B CA  1 
ATOM   678  C C   . SER B 2 43  ? -46.90633 -1.90360 9.57677   1.000 25.33435 ? 375 SER B C   1 
ATOM   679  O O   . SER B 2 43  ? -46.35338 -3.00946 9.52220   1.000 21.91529 ? 375 SER B O   1 
ATOM   680  C CB  . SER B 2 43  ? -47.93720 -1.38763 7.36948   1.000 25.32671 ? 375 SER B CB  1 
ATOM   681  O OG  . SER B 2 43  ? -47.41379 -0.08008 7.23516   1.000 23.79622 ? 375 SER B OG  1 
ATOM   682  N N   . THR B 2 44  ? -46.41105 -0.87109 10.26189  1.000 21.35420 ? 376 THR B N   1 
ATOM   683  C CA  . THR B 2 44  ? -45.24652 -0.94611 11.12306  1.000 23.31038 ? 376 THR B CA  1 
ATOM   684  C C   . THR B 2 44  ? -45.53863 -0.13172 12.37949  1.000 18.69483 ? 376 THR B C   1 
ATOM   685  O O   . THR B 2 44  ? -46.14252 0.93916  12.30677  1.000 19.57632 ? 376 THR B O   1 
ATOM   686  C CB  . THR B 2 44  ? -43.98985 -0.40392 10.40993  1.000 26.54040 ? 376 THR B CB  1 
ATOM   687  O OG1 . THR B 2 44  ? -43.71520 -1.19345 9.24476   1.000 24.43811 ? 376 THR B OG1 1 
ATOM   688  C CG2 . THR B 2 44  ? -42.77973 -0.45590 11.32521  1.000 24.10328 ? 376 THR B CG2 1 
ATOM   689  N N   . PHE B 2 45  ? -45.14881 -0.66581 13.53126  1.000 23.66001 ? 377 PHE B N   1 
ATOM   690  C CA  . PHE B 2 45  ? -45.19122 0.07360  14.79436  1.000 21.14414 ? 377 PHE B CA  1 
ATOM   691  C C   . PHE B 2 45  ? -44.15831 -0.61213 15.68405  1.000 25.43790 ? 377 PHE B C   1 
ATOM   692  O O   . PHE B 2 45  ? -44.47139 -1.47125 16.51548  1.000 24.13161 ? 377 PHE B O   1 
ATOM   693  C CB  . PHE B 2 45  ? -46.58161 0.07547  15.42837  1.000 25.17116 ? 377 PHE B CB  1 
ATOM   694  C CG  . PHE B 2 45  ? -46.81853 1.22580  16.38063  1.000 23.16788 ? 377 PHE B CG  1 
ATOM   695  C CD1 . PHE B 2 45  ? -45.99156 1.41452  17.47642  1.000 23.17696 ? 377 PHE B CD1 1 
ATOM   696  C CD2 . PHE B 2 45  ? -47.86097 2.11154  16.17522  1.000 25.84700 ? 377 PHE B CD2 1 
ATOM   697  C CE1 . PHE B 2 45  ? -46.19751 2.47695  18.35081  1.000 26.02522 ? 377 PHE B CE1 1 
ATOM   698  C CE2 . PHE B 2 45  ? -48.07713 3.17096  17.05269  1.000 21.67894 ? 377 PHE B CE2 1 
ATOM   699  C CZ  . PHE B 2 45  ? -47.24151 3.34871  18.13985  1.000 21.50515 ? 377 PHE B CZ  1 
ATOM   700  N N   . LYS B 2 46  ? -42.89845 -0.25682 15.46773  1.000 23.05806 ? 378 LYS B N   1 
ATOM   701  C CA  . LYS B 2 46  ? -41.76897 -0.96127 16.05150  1.000 25.56660 ? 378 LYS B CA  1 
ATOM   702  C C   . LYS B 2 46  ? -41.04871 -0.01945 17.00013  1.000 28.63958 ? 378 LYS B C   1 
ATOM   703  O O   . LYS B 2 46  ? -40.51690 1.00690  16.57322  1.000 22.90198 ? 378 LYS B O   1 
ATOM   704  C CB  . LYS B 2 46  ? -40.81295 -1.46364 14.97583  1.000 28.03625 ? 378 LYS B CB  1 
ATOM   705  C CG  . LYS B 2 46  ? -39.70487 -2.33140 15.51639  1.000 29.82506 ? 378 LYS B CG  1 
ATOM   706  C CD  . LYS B 2 46  ? -38.98652 -3.03858 14.37733  1.000 35.02275 ? 378 LYS B CD  1 
ATOM   707  C CE  . LYS B 2 46  ? -37.89781 -3.97623 14.89680  1.000 43.33931 ? 378 LYS B CE  1 
ATOM   708  N NZ  . LYS B 2 46  ? -36.88597 -4.27435 13.82954  1.000 40.62944 ? 378 LYS B NZ  1 
ATOM   709  N N   . CYS B 2 47  ? -41.04787 -0.36263 18.27778  1.000 24.82039 ? 379 CYS B N   1 
ATOM   710  C CA  . CYS B 2 47  ? -40.39270 0.43919  19.29343  1.000 27.29904 ? 379 CYS B CA  1 
ATOM   711  C C   . CYS B 2 47  ? -39.11370 -0.25988 19.72023  1.000 32.82094 ? 379 CYS B C   1 
ATOM   712  O O   . CYS B 2 47  ? -39.08959 -1.48186 19.90484  1.000 34.50187 ? 379 CYS B O   1 
ATOM   713  C CB  . CYS B 2 47  ? -41.32955 0.67893  20.47761  1.000 28.38098 ? 379 CYS B CB  1 
ATOM   714  S SG  . CYS B 2 47  ? -42.78294 1.65747  20.01812  1.000 33.84374 ? 379 CYS B SG  1 
ATOM   715  N N   . TYR B 2 48  ? -38.04422 0.51699  19.84515  1.000 26.84900 ? 380 TYR B N   1 
ATOM   716  C CA  . TYR B 2 48  ? -36.72125 -0.03773 20.06209  1.000 30.46379 ? 380 TYR B CA  1 
ATOM   717  C C   . TYR B 2 48  ? -36.26558 0.05730  21.50847  1.000 35.98843 ? 380 TYR B C   1 
ATOM   718  O O   . TYR B 2 48  ? -35.31860 -0.63762 21.88820  1.000 40.81570 ? 380 TYR B O   1 
ATOM   719  C CB  . TYR B 2 48  ? -35.71112 0.66179  19.14685  1.000 28.95443 ? 380 TYR B CB  1 
ATOM   720  C CG  . TYR B 2 48  ? -35.86874 0.24483  17.70755  1.000 29.69380 ? 380 TYR B CG  1 
ATOM   721  C CD1 . TYR B 2 48  ? -36.78339 0.87958  16.87748  1.000 25.54139 ? 380 TYR B CD1 1 
ATOM   722  C CD2 . TYR B 2 48  ? -35.12525 -0.79904 17.18642  1.000 30.91647 ? 380 TYR B CD2 1 
ATOM   723  C CE1 . TYR B 2 48  ? -36.94041 0.49465  15.55610  1.000 28.11398 ? 380 TYR B CE1 1 
ATOM   724  C CE2 . TYR B 2 48  ? -35.27025 -1.19311 15.86770  1.000 33.51392 ? 380 TYR B CE2 1 
ATOM   725  C CZ  . TYR B 2 48  ? -36.17343 -0.54321 15.05868  1.000 28.73169 ? 380 TYR B CZ  1 
ATOM   726  O OH  . TYR B 2 48  ? -36.32247 -0.93232 13.75823  1.000 27.86691 ? 380 TYR B OH  1 
ATOM   727  N N   . GLY B 2 49  ? -36.90646 0.90305  22.30709  1.000 37.01397 ? 381 GLY B N   1 
ATOM   728  C CA  . GLY B 2 49  ? -36.75034 0.87125  23.74357  1.000 41.29251 ? 381 GLY B CA  1 
ATOM   729  C C   . GLY B 2 49  ? -37.78575 -0.05171 24.34812  1.000 43.15688 ? 381 GLY B C   1 
ATOM   730  O O   . GLY B 2 49  ? -37.61760 -1.27428 24.32868  1.000 47.55757 ? 381 GLY B O   1 
ATOM   731  N N   . VAL B 2 50  ? -38.87135 0.51105  24.86562  1.000 40.37227 ? 382 VAL B N   1 
ATOM   732  C CA  . VAL B 2 50  ? -39.90967 -0.27104 25.51539  1.000 42.96260 ? 382 VAL B CA  1 
ATOM   733  C C   . VAL B 2 50  ? -41.18999 -0.17594 24.69383  1.000 41.33449 ? 382 VAL B C   1 
ATOM   734  O O   . VAL B 2 50  ? -41.29638 0.60372  23.74985  1.000 40.66466 ? 382 VAL B O   1 
ATOM   735  C CB  . VAL B 2 50  ? -40.14582 0.17413  26.97128  1.000 46.84973 ? 382 VAL B CB  1 
ATOM   736  C CG1 . VAL B 2 50  ? -38.96342 -0.22170 27.85800  1.000 42.21799 ? 382 VAL B CG1 1 
ATOM   737  C CG2 . VAL B 2 50  ? -40.40088 1.67602  27.03467  1.000 47.85589 ? 382 VAL B CG2 1 
ATOM   738  N N   . SER B 2 51  ? -42.16991 -0.99104 25.06715  1.000 37.48703 ? 383 SER B N   1 
ATOM   739  C CA  . SER B 2 51  ? -43.41821 -1.06851 24.33378  1.000 39.16552 ? 383 SER B CA  1 
ATOM   740  C C   . SER B 2 51  ? -44.29678 0.14900  24.62212  1.000 38.81528 ? 383 SER B C   1 
ATOM   741  O O   . SER B 2 51  ? -44.06314 0.88082  25.58870  1.000 37.93969 ? 383 SER B O   1 
ATOM   742  C CB  . SER B 2 51  ? -44.16302 -2.34580 24.71385  1.000 40.15048 ? 383 SER B CB  1 
ATOM   743  O OG  . SER B 2 51  ? -44.54408 -2.29517 26.07668  1.000 42.76402 ? 383 SER B OG  1 
ATOM   744  N N   . PRO B 2 52  ? -45.31197 0.38969  23.77967  1.000 36.10802 ? 384 PRO B N   1 
ATOM   745  C CA  . PRO B 2 52  ? -46.28662 1.45376  24.08540  1.000 35.58800 ? 384 PRO B CA  1 
ATOM   746  C C   . PRO B 2 52  ? -46.81426 1.42676  25.51100  1.000 43.31853 ? 384 PRO B C   1 
ATOM   747  O O   . PRO B 2 52  ? -46.81884 2.46568  26.18820  1.000 39.14048 ? 384 PRO B O   1 
ATOM   748  C CB  . PRO B 2 52  ? -47.39632 1.18743  23.06860  1.000 38.61598 ? 384 PRO B CB  1 
ATOM   749  C CG  . PRO B 2 52  ? -46.66484 0.62737  21.87800  1.000 35.99251 ? 384 PRO B CG  1 
ATOM   750  C CD  . PRO B 2 52  ? -45.49742 -0.16000 22.42115  1.000 37.75028 ? 384 PRO B CD  1 
ATOM   751  N N   . THR B 2 53  ? -47.26396 0.25917  25.98732  1.000 41.76515 ? 385 THR B N   1 
ATOM   752  C CA  . THR B 2 53  ? -47.80763 0.18250  27.33841  1.000 41.05449 ? 385 THR B CA  1 
ATOM   753  C C   . THR B 2 53  ? -46.77322 0.63142  28.35678  1.000 41.41302 ? 385 THR B C   1 
ATOM   754  O O   . THR B 2 53  ? -47.08893 1.38206  29.28560  1.000 46.69590 ? 385 THR B O   1 
ATOM   755  C CB  . THR B 2 53  ? -48.28074 -1.24071 27.64955  1.000 46.38914 ? 385 THR B CB  1 
ATOM   756  O OG1 . THR B 2 53  ? -48.96280 -1.78085 26.51190  1.000 51.25612 ? 385 THR B OG1 1 
ATOM   757  C CG2 . THR B 2 53  ? -49.22838 -1.24239 28.84353  1.000 46.30898 ? 385 THR B CG2 1 
ATOM   758  N N   . LYS B 2 54  ? -45.52338 0.20119  28.18033  1.000 40.96149 ? 386 LYS B N   1 
ATOM   759  C CA  . LYS B 2 54  ? -44.46397 0.61292  29.09090  1.000 41.68197 ? 386 LYS B CA  1 
ATOM   760  C C   . LYS B 2 54  ? -44.12970 2.09427  28.93641  1.000 44.46787 ? 386 LYS B C   1 
ATOM   761  O O   . LYS B 2 54  ? -43.73856 2.74505  29.91503  1.000 41.88063 ? 386 LYS B O   1 
ATOM   762  C CB  . LYS B 2 54  ? -43.22267 -0.24919 28.86729  1.000 44.27845 ? 386 LYS B CB  1 
ATOM   763  C CG  . LYS B 2 54  ? -42.07890 0.04923  29.82459  1.000 51.86985 ? 386 LYS B CG  1 
ATOM   764  C CD  . LYS B 2 54  ? -42.55425 0.18348  31.26224  1.000 56.74231 ? 386 LYS B CD  1 
ATOM   765  C CE  . LYS B 2 54  ? -41.77158 1.26574  31.98657  1.000 50.97457 ? 386 LYS B CE  1 
ATOM   766  N NZ  . LYS B 2 54  ? -42.47302 1.68353  33.23195  1.000 60.59243 ? 386 LYS B NZ  1 
ATOM   767  N N   . LEU B 2 55  ? -44.27646 2.64424  27.72582  1.000 41.81495 ? 387 LEU B N   1 
ATOM   768  C CA  . LEU B 2 55  ? -44.08041 4.08017  27.53682  1.000 42.05293 ? 387 LEU B CA  1 
ATOM   769  C C   . LEU B 2 55  ? -45.05155 4.89408  28.37967  1.000 41.37189 ? 387 LEU B C   1 
ATOM   770  O O   . LEU B 2 55  ? -44.74245 6.02947  28.76282  1.000 38.64771 ? 387 LEU B O   1 
ATOM   771  C CB  . LEU B 2 55  ? -44.25290 4.45361  26.06517  1.000 38.20961 ? 387 LEU B CB  1 
ATOM   772  C CG  . LEU B 2 55  ? -43.16785 4.05735  25.07311  1.000 39.15679 ? 387 LEU B CG  1 
ATOM   773  C CD1 . LEU B 2 55  ? -43.60345 4.47243  23.67504  1.000 33.54646 ? 387 LEU B CD1 1 
ATOM   774  C CD2 . LEU B 2 55  ? -41.83447 4.69665  25.46379  1.000 37.77230 ? 387 LEU B CD2 1 
ATOM   775  N N   . ASN B 2 56  ? -46.22801 4.33777  28.67217  1.000 41.74268 ? 388 ASN B N   1 
ATOM   776  C CA  . ASN B 2 56  ? -47.24823 5.08947  29.39003  1.000 41.75028 ? 388 ASN B CA  1 
ATOM   777  C C   . ASN B 2 56  ? -46.90611 5.32447  30.85148  1.000 40.22855 ? 388 ASN B C   1 
ATOM   778  O O   . ASN B 2 56  ? -47.59944 6.10236  31.51120  1.000 42.79181 ? 388 ASN B O   1 
ATOM   779  C CB  . ASN B 2 56  ? -48.59360 4.38121  29.27632  1.000 44.22076 ? 388 ASN B CB  1 
ATOM   780  C CG  . ASN B 2 56  ? -49.45965 4.99974  28.22208  1.000 39.20672 ? 388 ASN B CG  1 
ATOM   781  O OD1 . ASN B 2 56  ? -48.98962 5.83394  27.46485  1.000 42.72756 ? 388 ASN B OD1 1 
ATOM   782  N ND2 . ASN B 2 56  ? -50.72912 4.61388  28.16949  1.000 43.74462 ? 388 ASN B ND2 1 
ATOM   783  N N   . ASP B 2 57  ? -45.87132 4.68108  31.37386  1.000 38.38414 ? 389 ASP B N   1 
ATOM   784  C CA  . ASP B 2 57  ? -45.41835 4.93847  32.73010  1.000 45.26871 ? 389 ASP B CA  1 
ATOM   785  C C   . ASP B 2 57  ? -44.18276 5.82468  32.76262  1.000 44.78701 ? 389 ASP B C   1 
ATOM   786  O O   . ASP B 2 57  ? -43.58917 6.00158  33.82988  1.000 46.67384 ? 389 ASP B O   1 
ATOM   787  C CB  . ASP B 2 57  ? -45.13172 3.61945  33.44993  1.000 46.98665 ? 389 ASP B CB  1 
ATOM   788  C CG  . ASP B 2 57  ? -46.21038 2.57639  33.21239  1.000 53.42686 ? 389 ASP B CG  1 
ATOM   789  O OD1 . ASP B 2 57  ? -47.39574 2.96051  33.09045  1.000 52.01768 ? 389 ASP B OD1 1 
ATOM   790  O OD2 . ASP B 2 57  ? -45.86696 1.37381  33.13540  1.000 54.48106 ? 389 ASP B OD2 1 
ATOM   791  N N   . LEU B 2 58  ? -43.78394 6.38470  31.62209  1.000 41.40166 ? 390 LEU B N   1 
ATOM   792  C CA  . LEU B 2 58  ? -42.53340 7.11675  31.50395  1.000 38.47288 ? 390 LEU B CA  1 
ATOM   793  C C   . LEU B 2 58  ? -42.79112 8.58756  31.19107  1.000 31.84740 ? 390 LEU B C   1 
ATOM   794  O O   . LEU B 2 58  ? -43.77197 8.94367  30.53373  1.000 31.78865 ? 390 LEU B O   1 
ATOM   795  C CB  . LEU B 2 58  ? -41.63888 6.49374  30.42375  1.000 37.14642 ? 390 LEU B CB  1 
ATOM   796  C CG  . LEU B 2 58  ? -41.15651 5.05621  30.67642  1.000 39.42549 ? 390 LEU B CG  1 
ATOM   797  C CD1 . LEU B 2 58  ? -40.36387 4.52899  29.49460  1.000 43.25177 ? 390 LEU B CD1 1 
ATOM   798  C CD2 . LEU B 2 58  ? -40.31503 4.98473  31.94087  1.000 42.41277 ? 390 LEU B CD2 1 
ATOM   799  N N   . CYS B 2 59  ? -41.89021 9.43963  31.67627  1.000 32.57049 ? 391 CYS B N   1 
ATOM   800  C CA  . CYS B 2 59  ? -41.92444 10.86957 31.40688  1.000 29.84508 ? 391 CYS B CA  1 
ATOM   801  C C   . CYS B 2 59  ? -40.65473 11.26216 30.66940  1.000 26.22923 ? 391 CYS B C   1 
ATOM   802  O O   . CYS B 2 59  ? -39.57332 10.74572 30.96373  1.000 29.68171 ? 391 CYS B O   1 
ATOM   803  C CB  . CYS B 2 59  ? -42.03387 11.67606 32.69334  1.000 31.69136 ? 391 CYS B CB  1 
ATOM   804  S SG  . CYS B 2 59  ? -43.59571 11.51052 33.60229  1.000 38.01897 ? 391 CYS B SG  1 
ATOM   805  N N   . PHE B 2 60  ? -40.78148 12.19409 29.73092  1.000 26.77387 ? 392 PHE B N   1 
ATOM   806  C CA  . PHE B 2 60  ? -39.64480 12.64589 28.94608  1.000 23.53007 ? 392 PHE B CA  1 
ATOM   807  C C   . PHE B 2 60  ? -39.60055 14.16726 28.92078  1.000 19.43809 ? 392 PHE B C   1 
ATOM   808  O O   . PHE B 2 60  ? -40.60852 14.84180 29.14584  1.000 21.18383 ? 392 PHE B O   1 
ATOM   809  C CB  . PHE B 2 60  ? -39.72417 12.06043 27.52309  1.000 25.59810 ? 392 PHE B CB  1 
ATOM   810  C CG  . PHE B 2 60  ? -39.60511 10.56547 27.50650  1.000 26.66616 ? 392 PHE B CG  1 
ATOM   811  C CD1 . PHE B 2 60  ? -38.37001 9.96088  27.67595  1.000 25.09750 ? 392 PHE B CD1 1 
ATOM   812  C CD2 . PHE B 2 60  ? -40.72500 9.76891  27.36129  1.000 27.26975 ? 392 PHE B CD2 1 
ATOM   813  C CE1 . PHE B 2 60  ? -38.25586 8.58692  27.67827  1.000 29.18774 ? 392 PHE B CE1 1 
ATOM   814  C CE2 . PHE B 2 60  ? -40.61172 8.39489  27.36763  1.000 25.25766 ? 392 PHE B CE2 1 
ATOM   815  C CZ  . PHE B 2 60  ? -39.38121 7.81024  27.52590  1.000 23.52050 ? 392 PHE B CZ  1 
ATOM   816  N N   . THR B 2 61  ? -38.40408 14.70379 28.65393  1.000 21.52374 ? 393 THR B N   1 
ATOM   817  C CA  . THR B 2 61  ? -38.26588 16.15215 28.49483  1.000 21.25738 ? 393 THR B CA  1 
ATOM   818  C C   . THR B 2 61  ? -39.07228 16.64467 27.30687  1.000 22.44048 ? 393 THR B C   1 
ATOM   819  O O   . THR B 2 61  ? -39.83929 17.61342 27.40765  1.000 22.70287 ? 393 THR B O   1 
ATOM   820  C CB  . THR B 2 61  ? -36.79812 16.52671 28.29524  1.000 25.36939 ? 393 THR B CB  1 
ATOM   821  O OG1 . THR B 2 61  ? -35.98491 15.75274 29.16986  1.000 25.71498 ? 393 THR B OG1 1 
ATOM   822  C CG2 . THR B 2 61  ? -36.58102 18.02057 28.58249  1.000 24.08480 ? 393 THR B CG2 1 
ATOM   823  N N   . ASN B 2 62  ? -38.87910 16.00085 26.15598  1.000 21.37922 ? 394 ASN B N   1 
ATOM   824  C CA  . ASN B 2 62  ? -39.62290 16.28759 24.94283  1.000 20.44459 ? 394 ASN B CA  1 
ATOM   825  C C   . ASN B 2 62  ? -39.80611 14.98808 24.18316  1.000 18.93243 ? 394 ASN B C   1 
ATOM   826  O O   . ASN B 2 62  ? -39.07469 14.01658 24.39333  1.000 19.42774 ? 394 ASN B O   1 
ATOM   827  C CB  . ASN B 2 62  ? -38.89515 17.27462 24.01353  1.000 19.92686 ? 394 ASN B CB  1 
ATOM   828  C CG  . ASN B 2 62  ? -38.66952 18.61509 24.64818  1.000 25.11406 ? 394 ASN B CG  1 
ATOM   829  O OD1 . ASN B 2 62  ? -39.60554 19.39479 24.82173  1.000 26.08095 ? 394 ASN B OD1 1 
ATOM   830  N ND2 . ASN B 2 62  ? -37.41710 18.90182 24.99575  1.000 23.44531 ? 394 ASN B ND2 1 
ATOM   831  N N   . VAL B 2 63  ? -40.76185 15.00228 23.26056  1.000 17.53961 ? 395 VAL B N   1 
ATOM   832  C CA  . VAL B 2 63  ? -40.88715 13.96194 22.25207  1.000 20.03759 ? 395 VAL B CA  1 
ATOM   833  C C   . VAL B 2 63  ? -40.80152 14.63893 20.89680  1.000 20.16909 ? 395 VAL B C   1 
ATOM   834  O O   . VAL B 2 63  ? -41.40626 15.69909 20.69284  1.000 22.95183 ? 395 VAL B O   1 
ATOM   835  C CB  . VAL B 2 63  ? -42.20191 13.17702 22.38707  1.000 20.59936 ? 395 VAL B CB  1 
ATOM   836  C CG1 . VAL B 2 63  ? -42.39746 12.26390 21.15426  1.000 20.12792 ? 395 VAL B CG1 1 
ATOM   837  C CG2 . VAL B 2 63  ? -42.18671 12.36491 23.68237  1.000 23.69831 ? 395 VAL B CG2 1 
ATOM   838  N N   . TYR B 2 64  ? -40.01473 14.06420 19.99431  1.000 15.94401 ? 396 TYR B N   1 
ATOM   839  C CA  . TYR B 2 64  ? -39.92131 14.56905 18.63215  1.000 17.50393 ? 396 TYR B CA  1 
ATOM   840  C C   . TYR B 2 64  ? -40.61329 13.58072 17.71517  1.000 20.17303 ? 396 TYR B C   1 
ATOM   841  O O   . TYR B 2 64  ? -40.41600 12.36699 17.84491  1.000 20.09224 ? 396 TYR B O   1 
ATOM   842  C CB  . TYR B 2 64  ? -38.47045 14.77608 18.18967  1.000 21.59886 ? 396 TYR B CB  1 
ATOM   843  C CG  . TYR B 2 64  ? -37.73921 15.75319 19.07691  1.000 21.06256 ? 396 TYR B CG  1 
ATOM   844  C CD1 . TYR B 2 64  ? -37.86978 17.12639 18.89727  1.000 22.90016 ? 396 TYR B CD1 1 
ATOM   845  C CD2 . TYR B 2 64  ? -36.96353 15.29560 20.13528  1.000 24.87937 ? 396 TYR B CD2 1 
ATOM   846  C CE1 . TYR B 2 64  ? -37.21410 18.02310 19.73612  1.000 25.57140 ? 396 TYR B CE1 1 
ATOM   847  C CE2 . TYR B 2 64  ? -36.30900 16.18166 20.97700  1.000 27.19116 ? 396 TYR B CE2 1 
ATOM   848  C CZ  . TYR B 2 64  ? -36.43967 17.53984 20.77539  1.000 26.39374 ? 396 TYR B CZ  1 
ATOM   849  O OH  . TYR B 2 64  ? -35.77630 18.40230 21.63121  1.000 32.14090 ? 396 TYR B OH  1 
ATOM   850  N N   . ALA B 2 65  ? -41.42052 14.10431 16.80467  1.000 17.45054 ? 397 ALA B N   1 
ATOM   851  C CA  . ALA B 2 65  ? -42.14311 13.30477 15.82563  1.000 17.85757 ? 397 ALA B CA  1 
ATOM   852  C C   . ALA B 2 65  ? -41.68248 13.73450 14.43791  1.000 18.20375 ? 397 ALA B C   1 
ATOM   853  O O   . ALA B 2 65  ? -42.01542 14.83492 13.98846  1.000 19.82517 ? 397 ALA B O   1 
ATOM   854  C CB  . ALA B 2 65  ? -43.64771 13.48344 15.98987  1.000 18.31651 ? 397 ALA B CB  1 
ATOM   855  N N   . ASP B 2 66  ? -40.88955 12.88774 13.78276  1.000 17.84981 ? 398 ASP B N   1 
ATOM   856  C CA  . ASP B 2 66  ? -40.43221 13.12964 12.41704  1.000 17.62882 ? 398 ASP B CA  1 
ATOM   857  C C   . ASP B 2 66  ? -41.35654 12.39921 11.45320  1.000 21.12912 ? 398 ASP B C   1 
ATOM   858  O O   . ASP B 2 66  ? -41.67131 11.22825 11.67964  1.000 20.32396 ? 398 ASP B O   1 
ATOM   859  C CB  . ASP B 2 66  ? -38.99904 12.63694 12.23051  1.000 16.54309 ? 398 ASP B CB  1 
ATOM   860  C CG  . ASP B 2 66  ? -38.02535 13.27191 13.21460  1.000 18.33813 ? 398 ASP B CG  1 
ATOM   861  O OD1 . ASP B 2 66  ? -38.26792 14.41724 13.64389  1.000 20.23767 ? 398 ASP B OD1 1 
ATOM   862  O OD2 . ASP B 2 66  ? -37.02045 12.62433 13.55466  1.000 18.72022 ? 398 ASP B OD2 1 
ATOM   863  N N   . SER B 2 67  ? -41.76670 13.06723 10.36855  1.000 17.61768 ? 399 SER B N   1 
ATOM   864  C CA  . SER B 2 67  ? -42.70037 12.42957 9.45207   1.000 16.85243 ? 399 SER B CA  1 
ATOM   865  C C   . SER B 2 67  ? -42.36601 12.74697 7.99841   1.000 19.13684 ? 399 SER B C   1 
ATOM   866  O O   . SER B 2 67  ? -41.79969 13.79517 7.66809   1.000 16.90846 ? 399 SER B O   1 
ATOM   867  C CB  . SER B 2 67  ? -44.15047 12.81901 9.76523   1.000 17.80067 ? 399 SER B CB  1 
ATOM   868  O OG  . SER B 2 67  ? -44.32658 14.21921 9.72579   1.000 21.11910 ? 399 SER B OG  1 
ATOM   869  N N   . PHE B 2 68  ? -42.76090 11.82574 7.12499   1.000 16.19234 ? 400 PHE B N   1 
ATOM   870  C CA  . PHE B 2 68  ? -42.40590 11.91553 5.71727   1.000 14.94474 ? 400 PHE B CA  1 
ATOM   871  C C   . PHE B 2 68  ? -43.05143 10.74830 4.99296   1.000 17.99306 ? 400 PHE B C   1 
ATOM   872  O O   . PHE B 2 68  ? -43.65837 9.88836  5.63764   1.000 15.14800 ? 400 PHE B O   1 
ATOM   873  C CB  . PHE B 2 68  ? -40.88530 11.89188 5.53625   1.000 15.19231 ? 400 PHE B CB  1 
ATOM   874  C CG  . PHE B 2 68  ? -40.19739 10.76473 6.26745   1.000 17.99187 ? 400 PHE B CG  1 
ATOM   875  C CD1 . PHE B 2 68  ? -40.16094 9.48530  5.72032   1.000 17.74657 ? 400 PHE B CD1 1 
ATOM   876  C CD2 . PHE B 2 68  ? -39.54870 10.98686 7.47163   1.000 16.93200 ? 400 PHE B CD2 1 
ATOM   877  C CE1 . PHE B 2 68  ? -39.52840 8.44592  6.37910   1.000 18.88000 ? 400 PHE B CE1 1 
ATOM   878  C CE2 . PHE B 2 68  ? -38.90172 9.94491  8.14592   1.000 18.73489 ? 400 PHE B CE2 1 
ATOM   879  C CZ  . PHE B 2 68  ? -38.88669 8.66737  7.59306   1.000 16.68754 ? 400 PHE B CZ  1 
ATOM   880  N N   . VAL B 2 69  ? -42.89444 10.68790 3.66963   1.000 17.22881 ? 401 VAL B N   1 
ATOM   881  C CA  . VAL B 2 69  ? -43.44105 9.60667  2.86043   1.000 17.13790 ? 401 VAL B CA  1 
ATOM   882  C C   . VAL B 2 69  ? -42.29887 8.92339  2.11937   1.000 17.58825 ? 401 VAL B C   1 
ATOM   883  O O   . VAL B 2 69  ? -41.43224 9.60151  1.55234   1.000 17.07689 ? 401 VAL B O   1 
ATOM   884  C CB  . VAL B 2 69  ? -44.50427 10.13170 1.87555   1.000 21.12661 ? 401 VAL B CB  1 
ATOM   885  C CG1 . VAL B 2 69  ? -44.70717 9.15464  0.73777   1.000 19.05528 ? 401 VAL B CG1 1 
ATOM   886  C CG2 . VAL B 2 69  ? -45.82387 10.41624 2.61683   1.000 17.66755 ? 401 VAL B CG2 1 
ATOM   887  N N   . ILE B 2 70  ? -42.29473 7.57980  2.12475   1.000 15.37382 ? 402 ILE B N   1 
ATOM   888  C CA  . ILE B 2 70  ? -41.37885 6.76878  1.32159   1.000 15.39853 ? 402 ILE B CA  1 
ATOM   889  C C   . ILE B 2 70  ? -42.16369 5.61947  0.69559   1.000 18.75764 ? 402 ILE B C   1 
ATOM   890  O O   . ILE B 2 70  ? -43.37016 5.48061  0.90420   1.000 17.99767 ? 402 ILE B O   1 
ATOM   891  C CB  . ILE B 2 70  ? -40.18608 6.21747  2.13189   1.000 17.17902 ? 402 ILE B CB  1 
ATOM   892  C CG1 . ILE B 2 70  ? -40.67769 5.47983  3.38626   1.000 15.22084 ? 402 ILE B CG1 1 
ATOM   893  C CG2 . ILE B 2 70  ? -39.19247 7.33715  2.46502   1.000 19.68708 ? 402 ILE B CG2 1 
ATOM   894  C CD1 . ILE B 2 70  ? -39.56255 4.85524  4.20751   1.000 19.41231 ? 402 ILE B CD1 1 
ATOM   895  N N   . ARG B 2 71  ? -41.45834 4.78733  -0.07780  1.000 20.54908 ? 403 ARG B N   1 
ATOM   896  C CA  . ARG B 2 71  ? -42.03013 3.55418  -0.61677  1.000 19.64203 ? 403 ARG B CA  1 
ATOM   897  C C   . ARG B 2 71  ? -42.17439 2.50127  0.47059   1.000 19.15796 ? 403 ARG B C   1 
ATOM   898  O O   . ARG B 2 71  ? -41.34485 2.40195  1.37131   1.000 18.69171 ? 403 ARG B O   1 
ATOM   899  C CB  . ARG B 2 71  ? -41.13316 2.96851  -1.70053  1.000 21.26602 ? 403 ARG B CB  1 
ATOM   900  C CG  . ARG B 2 71  ? -41.16074 3.69435  -3.01247  1.000 21.89547 ? 403 ARG B CG  1 
ATOM   901  C CD  . ARG B 2 71  ? -39.84848 3.48824  -3.74162  1.000 23.68952 ? 403 ARG B CD  1 
ATOM   902  N NE  . ARG B 2 71  ? -39.42074 2.09064  -3.82885  1.000 22.55455 ? 403 ARG B NE  1 
ATOM   903  C CZ  . ARG B 2 71  ? -38.31655 1.70498  -4.45476  1.000 24.96833 ? 403 ARG B CZ  1 
ATOM   904  N NH1 . ARG B 2 71  ? -37.52088 2.58515  -5.05064  1.000 22.65709 ? 403 ARG B NH1 1 
ATOM   905  N NH2 . ARG B 2 71  ? -38.00417 0.40916  -4.49210  1.000 21.91955 ? 403 ARG B NH2 1 
ATOM   906  N N   . GLY B 2 72  ? -43.19168 1.65096  0.32731   1.000 23.30110 ? 404 GLY B N   1 
ATOM   907  C CA  . GLY B 2 72  ? -43.37157 0.56144  1.28185   1.000 21.61775 ? 404 GLY B CA  1 
ATOM   908  C C   . GLY B 2 72  ? -42.12849 -0.28192 1.48225   1.000 21.36564 ? 404 GLY B C   1 
ATOM   909  O O   . GLY B 2 72  ? -41.78234 -0.62955 2.61133   1.000 23.58458 ? 404 GLY B O   1 
ATOM   910  N N   . ASP B 2 73  ? -41.42250 -0.60577 0.39224   1.000 22.18815 ? 405 ASP B N   1 
ATOM   911  C CA  . ASP B 2 73  ? -40.23453 -1.44469 0.50641   1.000 23.30412 ? 405 ASP B CA  1 
ATOM   912  C C   . ASP B 2 73  ? -39.02531 -0.70201 1.07065   1.000 24.48596 ? 405 ASP B C   1 
ATOM   913  O O   . ASP B 2 73  ? -37.98045 -1.32713 1.29811   1.000 21.73115 ? 405 ASP B O   1 
ATOM   914  C CB  . ASP B 2 73  ? -39.89140 -2.09112 -0.85334  1.000 27.49426 ? 405 ASP B CB  1 
ATOM   915  C CG  . ASP B 2 73  ? -39.59010 -1.07569 -1.96610  1.000 31.63425 ? 405 ASP B CG  1 
ATOM   916  O OD1 . ASP B 2 73  ? -39.52306 0.14553  -1.70927  1.000 26.68263 ? 405 ASP B OD1 1 
ATOM   917  O OD2 . ASP B 2 73  ? -39.41420 -1.52003 -3.12602  1.000 28.34926 ? 405 ASP B OD2 1 
ATOM   918  N N   . GLU B 2 74  ? -39.15027 0.60009  1.31951   1.000 21.69583 ? 406 GLU B N   1 
ATOM   919  C CA  . GLU B 2 74  ? -38.10572 1.39084  1.95857   1.000 22.49183 ? 406 GLU B CA  1 
ATOM   920  C C   . GLU B 2 74  ? -38.30795 1.56780  3.45900   1.000 20.83382 ? 406 GLU B C   1 
ATOM   921  O O   . GLU B 2 74  ? -37.37923 1.99827  4.15092   1.000 19.47356 ? 406 GLU B O   1 
ATOM   922  C CB  . GLU B 2 74  ? -38.02648 2.76928  1.28475   1.000 20.94725 ? 406 GLU B CB  1 
ATOM   923  C CG  . GLU B 2 74  ? -37.47336 2.68848  -0.13839  1.000 20.43710 ? 406 GLU B CG  1 
ATOM   924  C CD  . GLU B 2 74  ? -37.55508 4.00878  -0.88884  1.000 18.91954 ? 406 GLU B CD  1 
ATOM   925  O OE1 . GLU B 2 74  ? -38.46643 4.81942  -0.59608  1.000 18.64045 ? 406 GLU B OE1 1 
ATOM   926  O OE2 . GLU B 2 74  ? -36.70518 4.22317  -1.78402  1.000 22.75120 ? 406 GLU B OE2 1 
ATOM   927  N N   . VAL B 2 75  ? -39.48761 1.23911  3.98539   1.000 21.58279 ? 407 VAL B N   1 
ATOM   928  C CA  . VAL B 2 75  ? -39.71500 1.40896  5.41984   1.000 21.14147 ? 407 VAL B CA  1 
ATOM   929  C C   . VAL B 2 75  ? -38.69087 0.63335  6.23962   1.000 22.53420 ? 407 VAL B C   1 
ATOM   930  O O   . VAL B 2 75  ? -38.28912 1.08014  7.32058   1.000 18.47467 ? 407 VAL B O   1 
ATOM   931  C CB  . VAL B 2 75  ? -41.16473 1.01835  5.76167   1.000 22.20694 ? 407 VAL B CB  1 
ATOM   932  C CG1 . VAL B 2 75  ? -41.38323 0.94418  7.28038   1.000 24.66485 ? 407 VAL B CG1 1 
ATOM   933  C CG2 . VAL B 2 75  ? -42.11271 2.01967  5.12524   1.000 21.31971 ? 407 VAL B CG2 1 
ATOM   934  N N   . ARG B 2 76  ? -38.19824 -0.50028 5.72194   1.000 25.23418 ? 408 ARG B N   1 
ATOM   935  C CA  . ARG B 2 76  ? -37.18492 -1.25851 6.45365   1.000 22.12572 ? 408 ARG B CA  1 
ATOM   936  C C   . ARG B 2 76  ? -35.89686 -0.46950 6.66872   1.000 22.77418 ? 408 ARG B C   1 
ATOM   937  O O   . ARG B 2 76  ? -35.14127 -0.77930 7.60003   1.000 22.05907 ? 408 ARG B O   1 
ATOM   938  C CB  . ARG B 2 76  ? -36.86980 -2.58037 5.73695   1.000 27.10318 ? 408 ARG B CB  1 
ATOM   939  C CG  . ARG B 2 76  ? -36.16345 -2.45701 4.39304   1.000 26.80466 ? 408 ARG B CG  1 
ATOM   940  C CD  . ARG B 2 76  ? -34.66033 -2.69602 4.51824   1.000 34.84711 ? 408 ARG B CD  1 
ATOM   941  N NE  . ARG B 2 76  ? -33.99380 -2.42886 3.24945   1.000 33.73332 ? 408 ARG B NE  1 
ATOM   942  C CZ  . ARG B 2 76  ? -32.73711 -2.02006 3.12067   1.000 34.69222 ? 408 ARG B CZ  1 
ATOM   943  N NH1 . ARG B 2 76  ? -31.95498 -1.83752 4.17568   1.000 34.64691 ? 408 ARG B NH1 1 
ATOM   944  N NH2 . ARG B 2 76  ? -32.25843 -1.76956 1.90079   1.000 37.62516 ? 408 ARG B NH2 1 
ATOM   945  N N   . GLN B 2 77  ? -35.62404 0.54339  5.84620   1.000 18.37698 ? 409 GLN B N   1 
ATOM   946  C CA  . GLN B 2 77  ? -34.43544 1.35982  6.07406   1.000 20.25776 ? 409 GLN B CA  1 
ATOM   947  C C   . GLN B 2 77  ? -34.60940 2.36078  7.20321   1.000 20.04132 ? 409 GLN B C   1 
ATOM   948  O O   . GLN B 2 77  ? -33.61602 2.94263  7.65143   1.000 18.90276 ? 409 GLN B O   1 
ATOM   949  C CB  . GLN B 2 77  ? -34.05247 2.11217  4.80600   1.000 20.17148 ? 409 GLN B CB  1 
ATOM   950  C CG  . GLN B 2 77  ? -33.86317 1.18869  3.62865   1.000 20.03967 ? 409 GLN B CG  1 
ATOM   951  C CD  . GLN B 2 77  ? -33.41871 1.93736  2.40679   1.000 23.75261 ? 409 GLN B CD  1 
ATOM   952  O OE1 . GLN B 2 77  ? -32.71524 2.94291  2.51184   1.000 18.00750 ? 409 GLN B OE1 1 
ATOM   953  N NE2 . GLN B 2 77  ? -33.80945 1.44665  1.23266   1.000 18.93906 ? 409 GLN B NE2 1 
ATOM   954  N N   . ILE B 2 78  ? -35.83019 2.58484  7.67017   1.000 18.39327 ? 410 ILE B N   1 
ATOM   955  C CA  . ILE B 2 78  ? -36.01954 3.48923  8.79940   1.000 19.42966 ? 410 ILE B CA  1 
ATOM   956  C C   . ILE B 2 78  ? -35.84364 2.67403  10.07446  1.000 23.97909 ? 410 ILE B C   1 
ATOM   957  O O   . ILE B 2 78  ? -36.81209 2.34702  10.76994  1.000 19.42366 ? 410 ILE B O   1 
ATOM   958  C CB  . ILE B 2 78  ? -37.38097 4.20078  8.73830   1.000 18.86974 ? 410 ILE B CB  1 
ATOM   959  C CG1 . ILE B 2 78  ? -37.60968 4.79647  7.34386   1.000 19.99547 ? 410 ILE B CG1 1 
ATOM   960  C CG2 . ILE B 2 78  ? -37.47163 5.30485  9.80708   1.000 19.34364 ? 410 ILE B CG2 1 
ATOM   961  C CD1 . ILE B 2 78  ? -36.47625 5.72304  6.86813   1.000 18.78597 ? 410 ILE B CD1 1 
ATOM   962  N N   . ALA B 2 79  ? -34.59304 2.34358  10.37664  1.000 21.93065 ? 411 ALA B N   1 
ATOM   963  C CA  . ALA B 2 79  ? -34.24755 1.47897  11.48689  1.000 23.97627 ? 411 ALA B CA  1 
ATOM   964  C C   . ALA B 2 79  ? -32.76137 1.63459  11.76681  1.000 24.32487 ? 411 ALA B C   1 
ATOM   965  O O   . ALA B 2 79  ? -31.98221 1.88347  10.83691  1.000 24.48540 ? 411 ALA B O   1 
ATOM   966  C CB  . ALA B 2 79  ? -34.57909 0.02268  11.16254  1.000 24.08341 ? 411 ALA B CB  1 
ATOM   967  N N   . PRO B 2 80  ? -32.32702 1.48220  13.01489  1.000 27.90218 ? 412 PRO B N   1 
ATOM   968  C CA  . PRO B 2 80  ? -30.88778 1.56218  13.30391  1.000 26.42264 ? 412 PRO B CA  1 
ATOM   969  C C   . PRO B 2 80  ? -30.10409 0.53813  12.49331  1.000 31.84706 ? 412 PRO B C   1 
ATOM   970  O O   . PRO B 2 80  ? -30.57406 -0.57499 12.23854  1.000 29.57871 ? 412 PRO B O   1 
ATOM   971  C CB  . PRO B 2 80  ? -30.80801 1.26874  14.80964  1.000 30.99288 ? 412 PRO B CB  1 
ATOM   972  C CG  . PRO B 2 80  ? -32.08203 0.56685  15.13038  1.000 31.49486 ? 412 PRO B CG  1 
ATOM   973  C CD  . PRO B 2 80  ? -33.11491 1.14497  14.21095  1.000 26.42107 ? 412 PRO B CD  1 
ATOM   974  N N   . GLY B 2 81  ? -28.91180 0.94150  12.05824  1.000 30.49845 ? 413 GLY B N   1 
ATOM   975  C CA  . GLY B 2 81  ? -27.98608 0.03896  11.40455  1.000 29.20895 ? 413 GLY B CA  1 
ATOM   976  C C   . GLY B 2 81  ? -28.26177 -0.27798 9.95144   1.000 34.50624 ? 413 GLY B C   1 
ATOM   977  O O   . GLY B 2 81  ? -27.55149 -1.11409 9.37855   1.000 35.88097 ? 413 GLY B O   1 
ATOM   978  N N   . GLN B 2 82  ? -29.25232 0.35740  9.32691   1.000 26.99290 ? 414 GLN B N   1 
ATOM   979  C CA  . GLN B 2 82  ? -29.61745 0.04048  7.95217   1.000 25.57341 ? 414 GLN B CA  1 
ATOM   980  C C   . GLN B 2 82  ? -28.88059 0.94768  6.97705   1.000 26.47934 ? 414 GLN B C   1 
ATOM   981  O O   . GLN B 2 82  ? -28.52318 2.07675  7.30652   1.000 27.36354 ? 414 GLN B O   1 
ATOM   982  C CB  . GLN B 2 82  ? -31.12389 0.19904  7.73007   1.000 25.95442 ? 414 GLN B CB  1 
ATOM   983  C CG  . GLN B 2 82  ? -31.98983 -0.63086 8.65290   1.000 29.33913 ? 414 GLN B CG  1 
ATOM   984  C CD  . GLN B 2 82  ? -31.65452 -2.10303 8.59359   1.000 32.95805 ? 414 GLN B CD  1 
ATOM   985  O OE1 . GLN B 2 82  ? -31.64748 -2.71363 7.51898   1.000 36.85058 ? 414 GLN B OE1 1 
ATOM   986  N NE2 . GLN B 2 82  ? -31.37013 -2.68694 9.75382   1.000 40.08102 ? 414 GLN B NE2 1 
ATOM   987  N N   . THR B 2 83  ? -28.66875 0.44970  5.75927   1.000 23.85418 ? 415 THR B N   1 
ATOM   988  C CA  . THR B 2 83  ? -28.15913 1.28015  4.67632   1.000 28.44981 ? 415 THR B CA  1 
ATOM   989  C C   . THR B 2 83  ? -29.07837 1.13981  3.47459   1.000 25.82321 ? 415 THR B C   1 
ATOM   990  O O   . THR B 2 83  ? -29.89502 0.22241  3.38891   1.000 28.62629 ? 415 THR B O   1 
ATOM   991  C CB  . THR B 2 83  ? -26.71843 0.91767  4.26234   1.000 30.17426 ? 415 THR B CB  1 
ATOM   992  O OG1 . THR B 2 83  ? -26.69360 -0.40640 3.72497   1.000 30.63941 ? 415 THR B OG1 1 
ATOM   993  C CG2 . THR B 2 83  ? -25.78967 0.98412  5.44280   1.000 32.53845 ? 415 THR B CG2 1 
ATOM   994  N N   . GLY B 2 84  ? -28.93325 2.05725  2.54875   1.000 24.32601 ? 416 GLY B N   1 
ATOM   995  C CA  . GLY B 2 84  ? -29.78460 2.09084  1.37848   1.000 22.96262 ? 416 GLY B CA  1 
ATOM   996  C C   . GLY B 2 84  ? -29.98036 3.52759  0.95817   1.000 19.19632 ? 416 GLY B C   1 
ATOM   997  O O   . GLY B 2 84  ? -29.47400 4.44634  1.57704   1.000 20.21827 ? 416 GLY B O   1 
ATOM   998  N N   . LYS B 2 85  ? -30.73977 3.69333  -0.11737  1.000 19.20713 ? 417 LYS B N   1 
ATOM   999  C CA  . LYS B 2 85  ? -30.93956 5.02063  -0.68669  1.000 19.02134 ? 417 LYS B CA  1 
ATOM   1000 C C   . LYS B 2 85  ? -31.54523 5.98019  0.33452   1.000 18.87688 ? 417 LYS B C   1 
ATOM   1001 O O   . LYS B 2 85  ? -31.16353 7.15519  0.39654   1.000 18.77956 ? 417 LYS B O   1 
ATOM   1002 C CB  . LYS B 2 85  ? -31.84465 4.92315  -1.91490  1.000 18.84484 ? 417 LYS B CB  1 
ATOM   1003 C CG  . LYS B 2 85  ? -31.84063 6.16011  -2.79830  1.000 17.73406 ? 417 LYS B CG  1 
ATOM   1004 C CD  . LYS B 2 85  ? -32.96096 6.10296  -3.83104  1.000 19.74968 ? 417 LYS B CD  1 
ATOM   1005 C CE  . LYS B 2 85  ? -32.90487 4.81017  -4.66798  1.000 20.83123 ? 417 LYS B CE  1 
ATOM   1006 N NZ  . LYS B 2 85  ? -34.16296 4.64442  -5.48918  1.000 18.21537 ? 417 LYS B NZ  1 
ATOM   1007 N N   . ILE B 2 86  ? -32.49882 5.50057  1.13363   1.000 17.63975 ? 418 ILE B N   1 
ATOM   1008 C CA  . ILE B 2 86  ? -33.17326 6.37391  2.09307   1.000 16.88141 ? 418 ILE B CA  1 
ATOM   1009 C C   . ILE B 2 86  ? -32.30619 6.59242  3.32160   1.000 17.01238 ? 418 ILE B C   1 
ATOM   1010 O O   . ILE B 2 86  ? -32.06612 7.73652  3.72915   1.000 19.29210 ? 418 ILE B O   1 
ATOM   1011 C CB  . ILE B 2 86  ? -34.55534 5.80356  2.47091   1.000 18.64168 ? 418 ILE B CB  1 
ATOM   1012 C CG1 . ILE B 2 86  ? -35.41800 5.63309  1.21902   1.000 19.83529 ? 418 ILE B CG1 1 
ATOM   1013 C CG2 . ILE B 2 86  ? -35.23822 6.67827  3.54658   1.000 15.41790 ? 418 ILE B CG2 1 
ATOM   1014 C CD1 . ILE B 2 86  ? -35.50092 6.87906  0.31522   1.000 21.85744 ? 418 ILE B CD1 1 
ATOM   1015 N N   . ALA B 2 87  ? -31.81282 5.50551  3.92222   1.000 16.25513 ? 419 ALA B N   1 
ATOM   1016 C CA  . ALA B 2 87  ? -30.97034 5.63863  5.11127   1.000 18.11377 ? 419 ALA B CA  1 
ATOM   1017 C C   . ALA B 2 87  ? -29.70719 6.44232  4.81655   1.000 18.85925 ? 419 ALA B C   1 
ATOM   1018 O O   . ALA B 2 87  ? -29.25756 7.22979  5.65631   1.000 18.67576 ? 419 ALA B O   1 
ATOM   1019 C CB  . ALA B 2 87  ? -30.60053 4.25987  5.66649   1.000 19.93435 ? 419 ALA B CB  1 
ATOM   1020 N N   . ASP B 2 88  ? -29.12215 6.26809  3.62997   1.000 19.02790 ? 420 ASP B N   1 
ATOM   1021 C CA  . ASP B 2 88  ? -27.85301 6.93702  3.34123   1.000 18.98838 ? 420 ASP B CA  1 
ATOM   1022 C C   . ASP B 2 88  ? -28.04934 8.41132  2.99741   1.000 15.44892 ? 420 ASP B C   1 
ATOM   1023 O O   . ASP B 2 88  ? -27.28135 9.26909  3.45081   1.000 18.77595 ? 420 ASP B O   1 
ATOM   1024 C CB  . ASP B 2 88  ? -27.11804 6.24692  2.17917   1.000 20.66219 ? 420 ASP B CB  1 
ATOM   1025 C CG  . ASP B 2 88  ? -26.62661 4.83805  2.51987   1.000 23.41807 ? 420 ASP B CG  1 
ATOM   1026 O OD1 . ASP B 2 88  ? -26.92241 4.30507  3.61170   1.000 21.53049 ? 420 ASP B OD1 1 
ATOM   1027 O OD2 . ASP B 2 88  ? -25.94259 4.25875  1.65543   1.000 26.07657 ? 420 ASP B OD2 1 
ATOM   1028 N N   . TYR B 2 89  ? -29.02122 8.72418  2.14049   1.000 16.55049 ? 421 TYR B N   1 
ATOM   1029 C CA  . TYR B 2 89  ? -29.10057 10.05295 1.53773   1.000 17.85710 ? 421 TYR B CA  1 
ATOM   1030 C C   . TYR B 2 89  ? -30.30287 10.86392 1.99342   1.000 17.62517 ? 421 TYR B C   1 
ATOM   1031 O O   . TYR B 2 89  ? -30.41839 12.02935 1.59061   1.000 15.66469 ? 421 TYR B O   1 
ATOM   1032 C CB  . TYR B 2 89  ? -29.12344 9.96463  -0.00504  1.000 15.39467 ? 421 TYR B CB  1 
ATOM   1033 C CG  . TYR B 2 89  ? -27.94691 9.22113  -0.62127  1.000 15.62141 ? 421 TYR B CG  1 
ATOM   1034 C CD1 . TYR B 2 89  ? -26.74064 9.08791  0.06027   1.000 19.93667 ? 421 TYR B CD1 1 
ATOM   1035 C CD2 . TYR B 2 89  ? -28.05309 8.63592  -1.89354  1.000 21.11293 ? 421 TYR B CD2 1 
ATOM   1036 C CE1 . TYR B 2 89  ? -25.67064 8.38647  -0.49496  1.000 21.51916 ? 421 TYR B CE1 1 
ATOM   1037 C CE2 . TYR B 2 89  ? -26.98617 7.94218  -2.45552  1.000 20.99672 ? 421 TYR B CE2 1 
ATOM   1038 C CZ  . TYR B 2 89  ? -25.80131 7.82313  -1.74883  1.000 22.91289 ? 421 TYR B CZ  1 
ATOM   1039 O OH  . TYR B 2 89  ? -24.73890 7.12911  -2.29399  1.000 23.31846 ? 421 TYR B OH  1 
ATOM   1040 N N   . ASN B 2 90  ? -31.20341 10.29832 2.81058   1.000 15.37642 ? 422 ASN B N   1 
ATOM   1041 C CA  . ASN B 2 90  ? -32.46703 10.99507 3.06267   1.000 18.61594 ? 422 ASN B CA  1 
ATOM   1042 C C   . ASN B 2 90  ? -32.82285 11.12775 4.53833   1.000 17.81890 ? 422 ASN B C   1 
ATOM   1043 O O   . ASN B 2 90  ? -33.10798 12.23671 5.00867   1.000 16.98624 ? 422 ASN B O   1 
ATOM   1044 C CB  . ASN B 2 90  ? -33.61901 10.30767 2.32482   1.000 15.87984 ? 422 ASN B CB  1 
ATOM   1045 C CG  . ASN B 2 90  ? -33.55551 10.54687 0.84138   1.000 15.79591 ? 422 ASN B CG  1 
ATOM   1046 O OD1 . ASN B 2 90  ? -34.14493 11.50193 0.32923   1.000 16.28362 ? 422 ASN B OD1 1 
ATOM   1047 N ND2 . ASN B 2 90  ? -32.79219 9.71166  0.14012   1.000 17.47536 ? 422 ASN B ND2 1 
ATOM   1048 N N   . TYR B 2 91  ? -32.83951 10.01561 5.27242   1.000 17.28919 ? 423 TYR B N   1 
ATOM   1049 C CA  . TYR B 2 91  ? -33.19739 10.05604 6.69010   1.000 17.09510 ? 423 TYR B CA  1 
ATOM   1050 C C   . TYR B 2 91  ? -32.48313 8.91779  7.40007   1.000 20.30771 ? 423 TYR B C   1 
ATOM   1051 O O   . TYR B 2 91  ? -32.68770 7.74989  7.04813   1.000 17.72664 ? 423 TYR B O   1 
ATOM   1052 C CB  . TYR B 2 91  ? -34.71485 9.94648  6.86776   1.000 19.22298 ? 423 TYR B CB  1 
ATOM   1053 C CG  . TYR B 2 91  ? -35.15894 10.03022 8.32163   1.000 16.59713 ? 423 TYR B CG  1 
ATOM   1054 C CD1 . TYR B 2 91  ? -35.26023 8.88627  9.11132   1.000 16.61911 ? 423 TYR B CD1 1 
ATOM   1055 C CD2 . TYR B 2 91  ? -35.47270 11.25802 8.89642   1.000 16.59621 ? 423 TYR B CD2 1 
ATOM   1056 C CE1 . TYR B 2 91  ? -35.67475 8.97351  10.47773  1.000 15.73471 ? 423 TYR B CE1 1 
ATOM   1057 C CE2 . TYR B 2 91  ? -35.88852 11.35871 10.24998  1.000 17.08055 ? 423 TYR B CE2 1 
ATOM   1058 C CZ  . TYR B 2 91  ? -35.98307 10.21213 11.02165  1.000 17.61171 ? 423 TYR B CZ  1 
ATOM   1059 O OH  . TYR B 2 91  ? -36.40049 10.30980 12.33620  1.000 17.41151 ? 423 TYR B OH  1 
ATOM   1060 N N   . LYS B 2 92  ? -31.66804 9.25186  8.40106   1.000 16.56392 ? 424 LYS B N   1 
ATOM   1061 C CA  . LYS B 2 92  ? -30.75017 8.29997  9.01559   1.000 19.06871 ? 424 LYS B CA  1 
ATOM   1062 C C   . LYS B 2 92  ? -31.01111 8.20906  10.50983  1.000 19.69706 ? 424 LYS B C   1 
ATOM   1063 O O   . LYS B 2 92  ? -30.89413 9.21208  11.22441  1.000 18.93460 ? 424 LYS B O   1 
ATOM   1064 C CB  . LYS B 2 92  ? -29.29754 8.70809  8.77282   1.000 16.81193 ? 424 LYS B CB  1 
ATOM   1065 C CG  . LYS B 2 92  ? -28.28804 7.77812  9.45071   1.000 16.80491 ? 424 LYS B CG  1 
ATOM   1066 C CD  . LYS B 2 92  ? -28.43903 6.35779  8.93871   1.000 20.09674 ? 424 LYS B CD  1 
ATOM   1067 C CE  . LYS B 2 92  ? -27.34999 5.44293  9.48704   1.000 23.58422 ? 424 LYS B CE  1 
ATOM   1068 N NZ  . LYS B 2 92  ? -27.47017 4.06831  8.91848   1.000 22.79084 ? 424 LYS B NZ  1 
ATOM   1069 N N   . LEU B 2 93  ? -31.33467 6.93008  11.01342  1.000 19.98009 ? 425 LEU B N   1 
ATOM   1070 C CA  . LEU B 2 93  ? -31.45507 6.74396  12.45805  1.000 21.49341 ? 425 LEU B CA  1 
ATOM   1071 C C   . LEU B 2 93  ? -30.12102 6.31582  13.06286  1.000 23.64409 ? 425 LEU B C   1 
ATOM   1072 O O   . LEU B 2 93  ? -29.34023 5.60460  12.41768  1.000 26.92388 ? 425 LEU B O   1 
ATOM   1073 C CB  . LEU B 2 93  ? -32.50677 5.68881  12.76934  1.000 21.42157 ? 425 LEU B CB  1 
ATOM   1074 C CG  . LEU B 2 93  ? -33.96391 6.10100  12.57000  1.000 20.90941 ? 425 LEU B CG  1 
ATOM   1075 C CD1 . LEU B 2 93  ? -34.89160 4.97166  12.99322  1.000 23.37504 ? 425 LEU B CD1 1 
ATOM   1076 C CD2 . LEU B 2 93  ? -34.26959 7.35988  13.35345  1.000 20.13216 ? 425 LEU B CD2 1 
ATOM   1077 N N   . PRO B 2 94  ? -29.84465 6.72092  14.30475  1.000 22.75805 ? 426 PRO B N   1 
ATOM   1078 C CA  . PRO B 2 94  ? -28.58721 6.32208  14.94968  1.000 27.40674 ? 426 PRO B CA  1 
ATOM   1079 C C   . PRO B 2 94  ? -28.59995 4.85533  15.34545  1.000 32.73761 ? 426 PRO B C   1 
ATOM   1080 O O   . PRO B 2 94  ? -29.65246 4.23873  15.53229  1.000 29.65996 ? 426 PRO B O   1 
ATOM   1081 C CB  . PRO B 2 94  ? -28.52102 7.21974  16.18777  1.000 28.23548 ? 426 PRO B CB  1 
ATOM   1082 C CG  . PRO B 2 94  ? -29.96157 7.48772  16.52253  1.000 26.19001 ? 426 PRO B CG  1 
ATOM   1083 C CD  . PRO B 2 94  ? -30.67626 7.56000  15.18510  1.000 20.58184 ? 426 PRO B CD  1 
ATOM   1084 N N   . ASP B 2 95  ? -27.39091 4.29987  15.48519  1.000 30.00904 ? 427 ASP B N   1 
ATOM   1085 C CA  . ASP B 2 95  ? -27.25926 2.89604  15.86716  1.000 37.04220 ? 427 ASP B CA  1 
ATOM   1086 C C   . ASP B 2 95  ? -27.91753 2.61259  17.21304  1.000 32.90721 ? 427 ASP B C   1 
ATOM   1087 O O   . ASP B 2 95  ? -28.36949 1.48956  17.45649  1.000 38.00727 ? 427 ASP B O   1 
ATOM   1088 C CB  . ASP B 2 95  ? -25.77991 2.49553  15.91512  1.000 38.31731 ? 427 ASP B CB  1 
ATOM   1089 C CG  . ASP B 2 95  ? -25.13368 2.43312  14.53719  1.000 44.73204 ? 427 ASP B CG  1 
ATOM   1090 O OD1 . ASP B 2 95  ? -25.82632 2.65210  13.51754  1.000 42.71747 ? 427 ASP B OD1 1 
ATOM   1091 O OD2 . ASP B 2 95  ? -23.91462 2.15974  14.47466  1.000 52.26261 ? 427 ASP B OD2 1 
ATOM   1092 N N   . ASP B 2 96  ? -27.98900 3.61086  18.09245  1.000 33.68458 ? 428 ASP B N   1 
ATOM   1093 C CA  . ASP B 2 96  ? -28.50464 3.42970  19.44168  1.000 36.17060 ? 428 ASP B CA  1 
ATOM   1094 C C   . ASP B 2 96  ? -29.92629 3.95064  19.60163  1.000 36.60986 ? 428 ASP B C   1 
ATOM   1095 O O   . ASP B 2 96  ? -30.35242 4.23614  20.72386  1.000 35.62385 ? 428 ASP B O   1 
ATOM   1096 C CB  . ASP B 2 96  ? -27.58029 4.10794  20.45295  1.000 38.70088 ? 428 ASP B CB  1 
ATOM   1097 C CG  . ASP B 2 96  ? -27.55499 5.61905  20.30265  1.000 42.56708 ? 428 ASP B CG  1 
ATOM   1098 O OD1 . ASP B 2 96  ? -28.09492 6.14614  19.29935  1.000 41.50002 ? 428 ASP B OD1 1 
ATOM   1099 O OD2 . ASP B 2 96  ? -26.99180 6.28410  21.19741  1.000 43.90167 ? 428 ASP B OD2 1 
ATOM   1100 N N   . PHE B 2 97  ? -30.65671 4.10000  18.50145  1.000 33.58218 ? 429 PHE B N   1 
ATOM   1101 C CA  . PHE B 2 97  ? -32.02743 4.58316  18.56790  1.000 30.76222 ? 429 PHE B CA  1 
ATOM   1102 C C   . PHE B 2 97  ? -32.86370 3.67490  19.46182  1.000 33.58129 ? 429 PHE B C   1 
ATOM   1103 O O   . PHE B 2 97  ? -32.73026 2.44532  19.42590  1.000 31.55333 ? 429 PHE B O   1 
ATOM   1104 C CB  . PHE B 2 97  ? -32.61433 4.64090  17.15337  1.000 27.66690 ? 429 PHE B CB  1 
ATOM   1105 C CG  . PHE B 2 97  ? -34.04252 5.11400  17.08817  1.000 24.53364 ? 429 PHE B CG  1 
ATOM   1106 C CD1 . PHE B 2 97  ? -34.35212 6.45451  17.23306  1.000 23.24611 ? 429 PHE B CD1 1 
ATOM   1107 C CD2 . PHE B 2 97  ? -35.07231 4.21264  16.85809  1.000 22.34708 ? 429 PHE B CD2 1 
ATOM   1108 C CE1 . PHE B 2 97  ? -35.66116 6.89466  17.15407  1.000 23.49762 ? 429 PHE B CE1 1 
ATOM   1109 C CE2 . PHE B 2 97  ? -36.38372 4.63659  16.78209  1.000 22.62930 ? 429 PHE B CE2 1 
ATOM   1110 C CZ  . PHE B 2 97  ? -36.68282 5.98361  16.92109  1.000 23.49500 ? 429 PHE B CZ  1 
ATOM   1111 N N   . THR B 2 98  ? -33.71135 4.29320  20.29223  1.000 28.29273 ? 430 THR B N   1 
ATOM   1112 C CA  . THR B 2 98  ? -34.59127 3.54710  21.18509  1.000 33.12066 ? 430 THR B CA  1 
ATOM   1113 C C   . THR B 2 98  ? -36.03140 4.05717  21.14612  1.000 32.07074 ? 430 THR B C   1 
ATOM   1114 O O   . THR B 2 98  ? -36.79518 3.78575  22.07568  1.000 32.79841 ? 430 THR B O   1 
ATOM   1115 C CB  . THR B 2 98  ? -34.05982 3.56985  22.62878  1.000 33.67300 ? 430 THR B CB  1 
ATOM   1116 O OG1 . THR B 2 98  ? -33.81466 4.92161  23.04639  1.000 33.41592 ? 430 THR B OG1 1 
ATOM   1117 C CG2 . THR B 2 98  ? -32.77126 2.74378  22.74082  1.000 34.93260 ? 430 THR B CG2 1 
ATOM   1118 N N   . GLY B 2 99  ? -36.42870 4.77381  20.09224  1.000 29.20327 ? 431 GLY B N   1 
ATOM   1119 C CA  . GLY B 2 99  ? -37.78396 5.28979  19.95947  1.000 27.89131 ? 431 GLY B CA  1 
ATOM   1120 C C   . GLY B 2 99  ? -38.68279 4.33433  19.20245  1.000 26.06580 ? 431 GLY B C   1 
ATOM   1121 O O   . GLY B 2 99  ? -38.46639 3.12123  19.20820  1.000 25.58000 ? 431 GLY B O   1 
ATOM   1122 N N   . CYS B 2 100 ? -39.69778 4.88422  18.52363  1.000 22.22529 ? 432 CYS B N   1 
ATOM   1123 C CA  . CYS B 2 100 ? -40.64277 4.08061  17.74952  1.000 21.00053 ? 432 CYS B CA  1 
ATOM   1124 C C   . CYS B 2 100 ? -40.70744 4.53628  16.30116  1.000 22.20956 ? 432 CYS B C   1 
ATOM   1125 O O   . CYS B 2 100 ? -40.63096 5.73327  16.00711  1.000 21.24479 ? 432 CYS B O   1 
ATOM   1126 C CB  . CYS B 2 100 ? -42.05184 4.14558  18.32075  1.000 21.64259 ? 432 CYS B CB  1 
ATOM   1127 S SG  . CYS B 2 100 ? -42.18708 3.64061  20.04104  1.000 25.34504 ? 432 CYS B SG  1 
ATOM   1128 N N   . VAL B 2 101 ? -40.88401 3.57100  15.40501  1.000 18.61071 ? 433 VAL B N   1 
ATOM   1129 C CA  . VAL B 2 101 ? -41.06537 3.82857  13.98310  1.000 17.53676 ? 433 VAL B CA  1 
ATOM   1130 C C   . VAL B 2 101 ? -42.44278 3.30260  13.60629  1.000 19.85836 ? 433 VAL B C   1 
ATOM   1131 O O   . VAL B 2 101 ? -42.73028 2.11279  13.80205  1.000 21.55110 ? 433 VAL B O   1 
ATOM   1132 C CB  . VAL B 2 101 ? -39.96829 3.16301  13.13810  1.000 18.12127 ? 433 VAL B CB  1 
ATOM   1133 C CG1 . VAL B 2 101 ? -40.25932 3.37745  11.66499  1.000 19.27794 ? 433 VAL B CG1 1 
ATOM   1134 C CG2 . VAL B 2 101 ? -38.57150 3.70892  13.52300  1.000 20.54004 ? 433 VAL B CG2 1 
ATOM   1135 N N   . ILE B 2 102 ? -43.28678 4.18397  13.07679  1.000 16.81089 ? 434 ILE B N   1 
ATOM   1136 C CA  . ILE B 2 102 ? -44.68714 3.89645  12.79042  1.000 17.96259 ? 434 ILE B CA  1 
ATOM   1137 C C   . ILE B 2 102 ? -44.95901 4.18533  11.32102  1.000 22.98464 ? 434 ILE B C   1 
ATOM   1138 O O   . ILE B 2 102 ? -44.52760 5.21802  10.80088  1.000 20.73345 ? 434 ILE B O   1 
ATOM   1139 C CB  . ILE B 2 102 ? -45.59374 4.75539  13.68557  1.000 17.69761 ? 434 ILE B CB  1 
ATOM   1140 C CG1 . ILE B 2 102 ? -45.23868 4.53733  15.16179  1.000 21.46408 ? 434 ILE B CG1 1 
ATOM   1141 C CG2 . ILE B 2 102 ? -47.05857 4.47142  13.40711  1.000 18.94095 ? 434 ILE B CG2 1 
ATOM   1142 C CD1 . ILE B 2 102 ? -45.66511 5.69877  16.05260  1.000 22.47617 ? 434 ILE B CD1 1 
ATOM   1143 N N   . ALA B 2 103 ? -45.68316 3.28783  10.64539  1.000 18.49223 ? 435 ALA B N   1 
ATOM   1144 C CA  . ALA B 2 103 ? -45.90896 3.49210  9.22283   1.000 19.11050 ? 435 ALA B CA  1 
ATOM   1145 C C   . ALA B 2 103 ? -47.24923 2.89208  8.82064   1.000 22.84153 ? 435 ALA B C   1 
ATOM   1146 O O   . ALA B 2 103 ? -47.75387 1.96940  9.47177   1.000 19.25231 ? 435 ALA B O   1 
ATOM   1147 C CB  . ALA B 2 103 ? -44.77201 2.88724  8.38488   1.000 19.10351 ? 435 ALA B CB  1 
ATOM   1148 N N   . TRP B 2 104 ? -47.82371 3.43199  7.74599   1.000 21.85973 ? 436 TRP B N   1 
ATOM   1149 C CA  . TRP B 2 104 ? -49.06502 2.89385  7.20379   1.000 23.67493 ? 436 TRP B CA  1 
ATOM   1150 C C   . TRP B 2 104 ? -49.16214 3.19437  5.71557   1.000 23.08187 ? 436 TRP B C   1 
ATOM   1151 O O   . TRP B 2 104 ? -48.65089 4.20742  5.23836   1.000 21.90040 ? 436 TRP B O   1 
ATOM   1152 C CB  . TRP B 2 104 ? -50.29118 3.44841  7.93455   1.000 20.04785 ? 436 TRP B CB  1 
ATOM   1153 C CG  . TRP B 2 104 ? -50.49649 4.93676  7.86719   1.000 24.17436 ? 436 TRP B CG  1 
ATOM   1154 C CD1 . TRP B 2 104 ? -51.33477 5.62134  7.02849   1.000 25.76732 ? 436 TRP B CD1 1 
ATOM   1155 C CD2 . TRP B 2 104 ? -49.87480 5.92500  8.70682   1.000 23.31587 ? 436 TRP B CD2 1 
ATOM   1156 N NE1 . TRP B 2 104 ? -51.27349 6.97457  7.29878   1.000 24.30743 ? 436 TRP B NE1 1 
ATOM   1157 C CE2 . TRP B 2 104 ? -50.38232 7.18320  8.32090   1.000 24.82940 ? 436 TRP B CE2 1 
ATOM   1158 C CE3 . TRP B 2 104 ? -48.94139 5.86132  9.74780   1.000 21.52483 ? 436 TRP B CE3 1 
ATOM   1159 C CZ2 . TRP B 2 104 ? -49.98428 8.36696  8.93551   1.000 25.10566 ? 436 TRP B CZ2 1 
ATOM   1160 C CZ3 . TRP B 2 104 ? -48.54939 7.04603  10.36481  1.000 24.67361 ? 436 TRP B CZ3 1 
ATOM   1161 C CH2 . TRP B 2 104 ? -49.06761 8.27658  9.95276   1.000 20.90433 ? 436 TRP B CH2 1 
ATOM   1162 N N   . ASN B 2 105 ? -49.83720 2.30220  4.98687   1.000 22.81227 ? 437 ASN B N   1 
ATOM   1163 C CA  . ASN B 2 105 ? -50.04015 2.50378  3.55810   1.000 22.80087 ? 437 ASN B CA  1 
ATOM   1164 C C   . ASN B 2 105 ? -50.90623 3.73626  3.31833   1.000 26.04222 ? 437 ASN B C   1 
ATOM   1165 O O   . ASN B 2 105 ? -51.96048 3.89832  3.94286   1.000 26.36890 ? 437 ASN B O   1 
ATOM   1166 C CB  . ASN B 2 105 ? -50.68684 1.26499  2.93345   1.000 22.06329 ? 437 ASN B CB  1 
ATOM   1167 C CG  . ASN B 2 105 ? -50.82015 1.37668  1.43234   1.000 21.80070 ? 437 ASN B CG  1 
ATOM   1168 O OD1 . ASN B 2 105 ? -51.58869 2.18392  0.93103   1.000 25.74936 ? 437 ASN B OD1 1 
ATOM   1169 N ND2 . ASN B 2 105 ? -50.06309 0.57587  0.71056   1.000 25.01742 ? 437 ASN B ND2 1 
ATOM   1170 N N   . SER B 2 106 ? -50.45569 4.61500  2.41194   1.000 22.65024 ? 438 SER B N   1 
ATOM   1171 C CA  . SER B 2 106 ? -51.17446 5.84181  2.08187   1.000 23.66129 ? 438 SER B CA  1 
ATOM   1172 C C   . SER B 2 106 ? -51.45961 5.94590  0.58509   1.000 26.44233 ? 438 SER B C   1 
ATOM   1173 O O   . SER B 2 106 ? -51.61081 7.04388  0.04475   1.000 26.40680 ? 438 SER B O   1 
ATOM   1174 C CB  . SER B 2 106 ? -50.41058 7.07369  2.57306   1.000 25.93992 ? 438 SER B CB  1 
ATOM   1175 O OG  . SER B 2 106 ? -49.13584 7.19304  1.95946   1.000 22.42978 ? 438 SER B OG  1 
ATOM   1176 N N   . ASN B 2 107 ? -51.55999 4.79789  -0.08727  1.000 27.54540 ? 439 ASN B N   1 
ATOM   1177 C CA  . ASN B 2 107 ? -51.87592 4.77860  -1.51233  1.000 30.47048 ? 439 ASN B CA  1 
ATOM   1178 C C   . ASN B 2 107 ? -53.11604 5.60676  -1.83396  1.000 31.64865 ? 439 ASN B C   1 
ATOM   1179 O O   . ASN B 2 107 ? -53.18883 6.23220  -2.89955  1.000 30.23288 ? 439 ASN B O   1 
ATOM   1180 C CB  . ASN B 2 107 ? -52.06444 3.32639  -1.96450  1.000 28.83535 ? 439 ASN B CB  1 
ATOM   1181 C CG  . ASN B 2 107 ? -51.97494 3.16397  -3.45968  1.000 33.67711 ? 439 ASN B CG  1 
ATOM   1182 O OD1 . ASN B 2 107 ? -51.11857 3.76257  -4.11866  1.000 28.38399 ? 439 ASN B OD1 1 
ATOM   1183 N ND2 . ASN B 2 107 ? -52.86175 2.34419  -4.01123  1.000 32.74269 ? 439 ASN B ND2 1 
ATOM   1184 N N   . ASN B 2 108 ? -54.08524 5.65679  -0.91254  1.000 32.84732 ? 440 ASN B N   1 
ATOM   1185 C CA  . ASN B 2 108 ? -55.33383 6.36355  -1.17031  1.000 32.21704 ? 440 ASN B CA  1 
ATOM   1186 C C   . ASN B 2 108 ? -55.20416 7.88191  -1.09092  1.000 37.27631 ? 440 ASN B C   1 
ATOM   1187 O O   . ASN B 2 108 ? -56.06175 8.58474  -1.63541  1.000 39.09546 ? 440 ASN B O   1 
ATOM   1188 C CB  . ASN B 2 108 ? -56.41879 5.89106  -0.19524  1.000 35.17529 ? 440 ASN B CB  1 
ATOM   1189 C CG  . ASN B 2 108 ? -56.13735 6.30540  1.24663   1.000 44.96003 ? 440 ASN B CG  1 
ATOM   1190 O OD1 . ASN B 2 108 ? -55.02184 6.13983  1.75701   1.000 41.99536 ? 440 ASN B OD1 1 
ATOM   1191 N ND2 . ASN B 2 108 ? -57.15323 6.85072  1.90987   1.000 45.85286 ? 440 ASN B ND2 1 
ATOM   1192 N N   . LEU B 2 109 ? -54.17396 8.40758  -0.42075  1.000 31.64379 ? 441 LEU B N   1 
ATOM   1193 C CA  . LEU B 2 109 ? -53.96650 9.84963  -0.30740  1.000 31.03823 ? 441 LEU B CA  1 
ATOM   1194 C C   . LEU B 2 109 ? -52.80983 10.37466 -1.14791  1.000 30.29181 ? 441 LEU B C   1 
ATOM   1195 O O   . LEU B 2 109 ? -52.87039 11.51626 -1.61454  1.000 31.69903 ? 441 LEU B O   1 
ATOM   1196 C CB  . LEU B 2 109 ? -53.70132 10.24502 1.15253   1.000 28.64790 ? 441 LEU B CB  1 
ATOM   1197 C CG  . LEU B 2 109 ? -54.59785 9.72127  2.27471   1.000 34.17593 ? 441 LEU B CG  1 
ATOM   1198 C CD1 . LEU B 2 109 ? -53.99781 10.05890 3.62483   1.000 33.43320 ? 441 LEU B CD1 1 
ATOM   1199 C CD2 . LEU B 2 109 ? -55.98531 10.31444 2.16093   1.000 36.78099 ? 441 LEU B CD2 1 
ATOM   1200 N N   . ASP B 2 110 ? -51.76767 9.57082  -1.36344  1.000 27.38838 ? 442 ASP B N   1 
ATOM   1201 C CA  . ASP B 2 110 ? -50.50615 10.06191 -1.90846  1.000 27.59405 ? 442 ASP B CA  1 
ATOM   1202 C C   . ASP B 2 110 ? -50.17896 9.50002  -3.29063  1.000 28.33418 ? 442 ASP B C   1 
ATOM   1203 O O   . ASP B 2 110 ? -49.06081 9.69521  -3.78202  1.000 24.21001 ? 442 ASP B O   1 
ATOM   1204 C CB  . ASP B 2 110 ? -49.37693 9.76693  -0.92044  1.000 24.23617 ? 442 ASP B CB  1 
ATOM   1205 C CG  . ASP B 2 110 ? -49.57453 10.48496 0.40161   1.000 23.46045 ? 442 ASP B CG  1 
ATOM   1206 O OD1 . ASP B 2 110 ? -50.02951 11.65650 0.37569   1.000 24.40184 ? 442 ASP B OD1 1 
ATOM   1207 O OD2 . ASP B 2 110 ? -49.28290 9.88240  1.46395   1.000 22.91911 ? 442 ASP B OD2 1 
ATOM   1208 N N   . SER B 2 111 ? -51.11824 8.81898  -3.93562  1.000 29.02649 ? 443 SER B N   1 
ATOM   1209 C CA  . SER B 2 111 ? -50.93176 8.38108  -5.31208  1.000 32.87762 ? 443 SER B CA  1 
ATOM   1210 C C   . SER B 2 111 ? -51.91504 9.10914  -6.21162  1.000 30.09007 ? 443 SER B C   1 
ATOM   1211 O O   . SER B 2 111 ? -52.94050 9.61876  -5.75983  1.000 35.58717 ? 443 SER B O   1 
ATOM   1212 C CB  . SER B 2 111 ? -51.11490 6.86900  -5.45767  1.000 30.23418 ? 443 SER B CB  1 
ATOM   1213 O OG  . SER B 2 111 ? -49.98720 6.18838  -4.93311  1.000 37.89311 ? 443 SER B OG  1 
ATOM   1214 N N   . LYS B 2 112 ? -51.57977 9.16287  -7.49630  1.000 36.19018 ? 444 LYS B N   1 
ATOM   1215 C CA  . LYS B 2 112 ? -52.40982 9.83243  -8.48092  1.000 35.80586 ? 444 LYS B CA  1 
ATOM   1216 C C   . LYS B 2 112 ? -52.36918 9.04025  -9.77389  1.000 34.80155 ? 444 LYS B C   1 
ATOM   1217 O O   . LYS B 2 112 ? -51.32662 8.49378  -10.14267 1.000 33.68081 ? 444 LYS B O   1 
ATOM   1218 C CB  . LYS B 2 112 ? -51.93050 11.26512 -8.76282  1.000 39.08673 ? 444 LYS B CB  1 
ATOM   1219 C CG  . LYS B 2 112 ? -52.45113 12.33233 -7.82497  1.000 42.09843 ? 444 LYS B CG  1 
ATOM   1220 C CD  . LYS B 2 112 ? -51.89866 13.69218 -8.24411  1.000 44.79130 ? 444 LYS B CD  1 
ATOM   1221 C CE  . LYS B 2 112 ? -51.65818 14.59034 -7.03625  1.000 40.43600 ? 444 LYS B CE  1 
ATOM   1222 N NZ  . LYS B 2 112 ? -50.68150 15.67440 -7.34472  1.000 40.55643 ? 444 LYS B NZ  1 
ATOM   1223 N N   . VAL B 2 113 ? -53.51072 8.97554  -10.45573 1.000 39.44854 ? 445 VAL B N   1 
ATOM   1224 C CA  . VAL B 2 113 ? -53.50678 8.51604  -11.83565 1.000 36.97907 ? 445 VAL B CA  1 
ATOM   1225 C C   . VAL B 2 113 ? -52.59117 9.42254  -12.64208 1.000 36.28821 ? 445 VAL B C   1 
ATOM   1226 O O   . VAL B 2 113 ? -52.69849 10.65433 -12.58732 1.000 40.32638 ? 445 VAL B O   1 
ATOM   1227 C CB  . VAL B 2 113 ? -54.93468 8.49496  -12.39703 1.000 36.75625 ? 445 VAL B CB  1 
ATOM   1228 C CG1 . VAL B 2 113 ? -54.90295 8.48721  -13.91084 1.000 42.44927 ? 445 VAL B CG1 1 
ATOM   1229 C CG2 . VAL B 2 113 ? -55.67295 7.26569  -11.88558 1.000 42.23870 ? 445 VAL B CG2 1 
ATOM   1230 N N   . GLY B 2 114 ? -51.66060 8.81806  -13.37029 1.000 34.25295 ? 446 GLY B N   1 
ATOM   1231 C CA  . GLY B 2 114 ? -50.67980 9.57088  -14.11365 1.000 37.79494 ? 446 GLY B CA  1 
ATOM   1232 C C   . GLY B 2 114 ? -49.43887 9.94688  -13.33506 1.000 37.09664 ? 446 GLY B C   1 
ATOM   1233 O O   . GLY B 2 114 ? -48.50212 10.49666 -13.92700 1.000 40.93411 ? 446 GLY B O   1 
ATOM   1234 N N   . GLY B 2 115 ? -49.40382 9.67297  -12.03042 1.000 40.37563 ? 447 GLY B N   1 
ATOM   1235 C CA  . GLY B 2 115 ? -48.22920 9.91195  -11.21197 1.000 35.00020 ? 447 GLY B CA  1 
ATOM   1236 C C   . GLY B 2 115 ? -48.32019 11.13557 -10.32534 1.000 37.30809 ? 447 GLY B C   1 
ATOM   1237 O O   . GLY B 2 115 ? -48.53080 12.24604 -10.82001 1.000 34.72980 ? 447 GLY B O   1 
ATOM   1238 N N   . ASN B 2 116 ? -48.17847 10.94842 -9.00977  1.000 34.37563 ? 448 ASN B N   1 
ATOM   1239 C CA  . ASN B 2 116 ? -48.05779 12.07485 -8.09516  1.000 32.56216 ? 448 ASN B CA  1 
ATOM   1240 C C   . ASN B 2 116 ? -46.60239 12.51405 -8.07190  1.000 33.16730 ? 448 ASN B C   1 
ATOM   1241 O O   . ASN B 2 116 ? -45.70690 11.69942 -7.84272  1.000 36.08083 ? 448 ASN B O   1 
ATOM   1242 C CB  . ASN B 2 116 ? -48.52861 11.69015 -6.68717  1.000 31.00044 ? 448 ASN B CB  1 
ATOM   1243 C CG  . ASN B 2 116 ? -48.54672 12.87416 -5.72862  1.000 30.30575 ? 448 ASN B CG  1 
ATOM   1244 O OD1 . ASN B 2 116 ? -48.28598 14.01029 -6.12101  1.000 31.69144 ? 448 ASN B OD1 1 
ATOM   1245 N ND2 . ASN B 2 116 ? -48.87476 12.61197 -4.46665  1.000 31.49643 ? 448 ASN B ND2 1 
ATOM   1246 N N   . TYR B 2 117 ? -46.35221 13.79147 -8.33147  1.000 28.08458 ? 449 TYR B N   1 
ATOM   1247 C CA  . TYR B 2 117 ? -44.97974 14.27501 -8.32825  1.000 29.05225 ? 449 TYR B CA  1 
ATOM   1248 C C   . TYR B 2 117 ? -44.66123 15.13008 -7.10582  1.000 25.70991 ? 449 TYR B C   1 
ATOM   1249 O O   . TYR B 2 117 ? -43.56702 15.69146 -7.02421  1.000 24.68728 ? 449 TYR B O   1 
ATOM   1250 C CB  . TYR B 2 117 ? -44.69586 14.98998 -9.64827  1.000 37.95625 ? 449 TYR B CB  1 
ATOM   1251 C CG  . TYR B 2 117 ? -44.75418 13.96363 -10.77050 1.000 38.53116 ? 449 TYR B CG  1 
ATOM   1252 C CD1 . TYR B 2 117 ? -43.68868 13.09493 -10.99117 1.000 40.48476 ? 449 TYR B CD1 1 
ATOM   1253 C CD2 . TYR B 2 117 ? -45.90095 13.79453 -11.53481 1.000 41.78491 ? 449 TYR B CD2 1 
ATOM   1254 C CE1 . TYR B 2 117 ? -43.73680 12.12413 -11.97222 1.000 41.79344 ? 449 TYR B CE1 1 
ATOM   1255 C CE2 . TYR B 2 117 ? -45.96072 12.82021 -12.53284 1.000 43.53015 ? 449 TYR B CE2 1 
ATOM   1256 C CZ  . TYR B 2 117 ? -44.87471 11.98980 -12.74248 1.000 47.50128 ? 449 TYR B CZ  1 
ATOM   1257 O OH  . TYR B 2 117 ? -44.91840 11.02127 -13.72107 1.000 50.78784 ? 449 TYR B OH  1 
ATOM   1258 N N   . ASN B 2 118 ? -45.55608 15.16357 -6.11341  1.000 24.20592 ? 450 ASN B N   1 
ATOM   1259 C CA  . ASN B 2 118 ? -45.32479 16.00054 -4.93876  1.000 22.45665 ? 450 ASN B CA  1 
ATOM   1260 C C   . ASN B 2 118 ? -44.20544 15.47345 -4.05329  1.000 21.42229 ? 450 ASN B C   1 
ATOM   1261 O O   . ASN B 2 118 ? -43.54589 16.26680 -3.36462  1.000 21.52014 ? 450 ASN B O   1 
ATOM   1262 C CB  . ASN B 2 118 ? -46.60162 16.13081 -4.11833  1.000 25.23501 ? 450 ASN B CB  1 
ATOM   1263 C CG  . ASN B 2 118 ? -47.58393 17.10331 -4.73210  1.000 27.96874 ? 450 ASN B CG  1 
ATOM   1264 O OD1 . ASN B 2 118 ? -47.19103 18.03027 -5.43577  1.000 28.99729 ? 450 ASN B OD1 1 
ATOM   1265 N ND2 . ASN B 2 118 ? -48.86398 16.88810 -4.48354  1.000 30.18073 ? 450 ASN B ND2 1 
ATOM   1266 N N   . TYR B 2 119 ? -43.98741 14.16136 -4.03323  1.000 18.69523 ? 451 TYR B N   1 
ATOM   1267 C CA  . TYR B 2 119 ? -43.03140 13.53915 -3.11896  1.000 19.59415 ? 451 TYR B CA  1 
ATOM   1268 C C   . TYR B 2 119 ? -41.74729 13.17505 -3.84535  1.000 21.84537 ? 451 TYR B C   1 
ATOM   1269 O O   . TYR B 2 119 ? -41.78672 12.50513 -4.88108  1.000 22.72305 ? 451 TYR B O   1 
ATOM   1270 C CB  . TYR B 2 119 ? -43.63023 12.28482 -2.47917  1.000 19.31657 ? 451 TYR B CB  1 
ATOM   1271 C CG  . TYR B 2 119 ? -44.76933 12.58328 -1.52648  1.000 21.67967 ? 451 TYR B CG  1 
ATOM   1272 C CD1 . TYR B 2 119 ? -44.51929 13.02771 -0.23139  1.000 20.93516 ? 451 TYR B CD1 1 
ATOM   1273 C CD2 . TYR B 2 119 ? -46.08774 12.41782 -1.91860  1.000 22.30622 ? 451 TYR B CD2 1 
ATOM   1274 C CE1 . TYR B 2 119 ? -45.56067 13.29142 0.65334   1.000 19.63099 ? 451 TYR B CE1 1 
ATOM   1275 C CE2 . TYR B 2 119 ? -47.13939 12.69171 -1.03848  1.000 25.16548 ? 451 TYR B CE2 1 
ATOM   1276 C CZ  . TYR B 2 119 ? -46.86830 13.12090 0.23943   1.000 23.03261 ? 451 TYR B CZ  1 
ATOM   1277 O OH  . TYR B 2 119 ? -47.90363 13.38911 1.10644   1.000 23.98817 ? 451 TYR B OH  1 
ATOM   1278 N N   . ARG B 2 120 ? -40.61110 13.58291 -3.27780  1.000 18.87461 ? 452 ARG B N   1 
ATOM   1279 C CA  . ARG B 2 120 ? -39.30546 13.35318 -3.87424  1.000 18.34552 ? 452 ARG B CA  1 
ATOM   1280 C C   . ARG B 2 120 ? -38.34946 12.77257 -2.84911  1.000 18.12719 ? 452 ARG B C   1 
ATOM   1281 O O   . ARG B 2 120 ? -38.57258 12.84532 -1.64184  1.000 18.24214 ? 452 ARG B O   1 
ATOM   1282 C CB  . ARG B 2 120 ? -38.71694 14.64565 -4.45559  1.000 22.58964 ? 452 ARG B CB  1 
ATOM   1283 C CG  . ARG B 2 120 ? -39.52984 15.18209 -5.62076  1.000 21.09853 ? 452 ARG B CG  1 
ATOM   1284 C CD  . ARG B 2 120 ? -38.85599 16.38393 -6.24907  1.000 23.94764 ? 452 ARG B CD  1 
ATOM   1285 N NE  . ARG B 2 120 ? -38.75995 17.51796 -5.33613  1.000 20.63864 ? 452 ARG B NE  1 
ATOM   1286 C CZ  . ARG B 2 120 ? -38.17991 18.66348 -5.65255  1.000 22.25760 ? 452 ARG B CZ  1 
ATOM   1287 N NH1 . ARG B 2 120 ? -37.65680 18.86013 -6.86169  1.000 19.34908 ? 452 ARG B NH1 1 
ATOM   1288 N NH2 . ARG B 2 120 ? -38.10411 19.62793 -4.73410  1.000 21.41172 ? 452 ARG B NH2 1 
ATOM   1289 N N   . TYR B 2 121 ? -37.27447 12.18322 -3.35958  1.000 17.52598 ? 453 TYR B N   1 
ATOM   1290 C CA  . TYR B 2 121 ? -36.21567 11.62762 -2.53688  1.000 15.37450 ? 453 TYR B CA  1 
ATOM   1291 C C   . TYR B 2 121 ? -34.88752 12.02198 -3.16486  1.000 18.09983 ? 453 TYR B C   1 
ATOM   1292 O O   . TYR B 2 121 ? -34.81426 12.31706 -4.36424  1.000 16.87616 ? 453 TYR B O   1 
ATOM   1293 C CB  . TYR B 2 121 ? -36.32296 10.09993 -2.43781  1.000 17.02122 ? 453 TYR B CB  1 
ATOM   1294 C CG  . TYR B 2 121 ? -36.27799 9.44575  -3.81335  1.000 15.36247 ? 453 TYR B CG  1 
ATOM   1295 C CD1 . TYR B 2 121 ? -37.43877 9.31141  -4.58443  1.000 18.96390 ? 453 TYR B CD1 1 
ATOM   1296 C CD2 . TYR B 2 121 ? -35.07774 8.98348  -4.34105  1.000 18.21691 ? 453 TYR B CD2 1 
ATOM   1297 C CE1 . TYR B 2 121 ? -37.39519 8.70806  -5.85756  1.000 21.24443 ? 453 TYR B CE1 1 
ATOM   1298 C CE2 . TYR B 2 121 ? -35.02339 8.39700  -5.59500  1.000 18.67772 ? 453 TYR B CE2 1 
ATOM   1299 C CZ  . TYR B 2 121 ? -36.17755 8.26447  -6.34743  1.000 20.49175 ? 453 TYR B CZ  1 
ATOM   1300 O OH  . TYR B 2 121 ? -36.08538 7.67607  -7.59036  1.000 23.45068 ? 453 TYR B OH  1 
ATOM   1301 N N   . ARG B 2 122 ? -33.83442 12.01630 -2.35136  1.000 15.24309 ? 454 ARG B N   1 
ATOM   1302 C CA  . ARG B 2 122 ? -32.48911 12.30066 -2.84009  1.000 14.46811 ? 454 ARG B CA  1 
ATOM   1303 C C   . ARG B 2 122 ? -31.86447 11.01280 -3.35931  1.000 17.49648 ? 454 ARG B C   1 
ATOM   1304 O O   . ARG B 2 122 ? -31.77966 10.01481 -2.63042  1.000 15.56205 ? 454 ARG B O   1 
ATOM   1305 C CB  . ARG B 2 122 ? -31.60229 12.91094 -1.75099  1.000 17.47003 ? 454 ARG B CB  1 
ATOM   1306 C CG  . ARG B 2 122 ? -30.19613 13.33868 -2.25048  1.000 17.01735 ? 454 ARG B CG  1 
ATOM   1307 C CD  . ARG B 2 122 ? -29.40215 14.09603 -1.16563  1.000 16.60409 ? 454 ARG B CD  1 
ATOM   1308 N NE  . ARG B 2 122 ? -30.16347 15.22953 -0.64974  1.000 17.55318 ? 454 ARG B NE  1 
ATOM   1309 C CZ  . ARG B 2 122 ? -30.28576 16.40691 -1.24848  1.000 21.30238 ? 454 ARG B CZ  1 
ATOM   1310 N NH1 . ARG B 2 122 ? -29.63123 16.69098 -2.37048  1.000 17.62412 ? 454 ARG B NH1 1 
ATOM   1311 N NH2 . ARG B 2 122 ? -31.09623 17.32168 -0.71581  1.000 18.68707 ? 454 ARG B NH2 1 
ATOM   1312 N N   . LEU B 2 123 ? -31.39785 11.05203 -4.60900  1.000 15.17938 ? 455 LEU B N   1 
ATOM   1313 C CA  . LEU B 2 123 ? -30.77187 9.89564  -5.23869  1.000 17.07525 ? 455 LEU B CA  1 
ATOM   1314 C C   . LEU B 2 123 ? -29.24633 9.95453  -5.23593  1.000 19.92621 ? 455 LEU B C   1 
ATOM   1315 O O   . LEU B 2 123 ? -28.60050 8.90317  -5.32777  1.000 20.31513 ? 455 LEU B O   1 
ATOM   1316 C CB  . LEU B 2 123 ? -31.27549 9.76014  -6.68677  1.000 17.73964 ? 455 LEU B CB  1 
ATOM   1317 C CG  . LEU B 2 123 ? -30.68666 8.64184  -7.57002  1.000 18.52364 ? 455 LEU B CG  1 
ATOM   1318 C CD1 . LEU B 2 123 ? -30.80125 7.29077  -6.87170  1.000 18.24268 ? 455 LEU B CD1 1 
ATOM   1319 C CD2 . LEU B 2 123 ? -31.35346 8.60636  -8.95216  1.000 17.80802 ? 455 LEU B CD2 1 
ATOM   1320 N N   . PHE B 2 124 ? -28.65268 11.14611 -5.12623  1.000 16.85735 ? 456 PHE B N   1 
ATOM   1321 C CA  . PHE B 2 124 ? -27.20950 11.32221 -5.22619  1.000 18.69759 ? 456 PHE B CA  1 
ATOM   1322 C C   . PHE B 2 124 ? -26.70699 12.12583 -4.03620  1.000 18.42558 ? 456 PHE B C   1 
ATOM   1323 O O   . PHE B 2 124 ? -27.31893 13.12899 -3.67230  1.000 18.33934 ? 456 PHE B O   1 
ATOM   1324 C CB  . PHE B 2 124 ? -26.83672 12.07250 -6.52580  1.000 18.91540 ? 456 PHE B CB  1 
ATOM   1325 C CG  . PHE B 2 124 ? -27.43132 11.48179 -7.77027  1.000 20.68049 ? 456 PHE B CG  1 
ATOM   1326 C CD1 . PHE B 2 124 ? -26.79386 10.43828 -8.42529  1.000 22.04183 ? 456 PHE B CD1 1 
ATOM   1327 C CD2 . PHE B 2 124 ? -28.60489 12.00504 -8.31618  1.000 18.14681 ? 456 PHE B CD2 1 
ATOM   1328 C CE1 . PHE B 2 124 ? -27.33338 9.90697  -9.58996  1.000 18.05979 ? 456 PHE B CE1 1 
ATOM   1329 C CE2 . PHE B 2 124 ? -29.13494 11.49634 -9.47271  1.000 21.82669 ? 456 PHE B CE2 1 
ATOM   1330 C CZ  . PHE B 2 124 ? -28.50225 10.43681 -10.11225 1.000 19.40334 ? 456 PHE B CZ  1 
ATOM   1331 N N   . ARG B 2 125 ? -25.57784 11.71370 -3.45728  1.000 18.77767 ? 457 ARG B N   1 
ATOM   1332 C CA  . ARG B 2 125 ? -24.94340 12.50567 -2.40934  1.000 19.23050 ? 457 ARG B CA  1 
ATOM   1333 C C   . ARG B 2 125 ? -23.49962 12.04732 -2.25872  1.000 23.26804 ? 457 ARG B C   1 
ATOM   1334 O O   . ARG B 2 125 ? -23.21798 10.85366 -2.35155  1.000 23.45076 ? 457 ARG B O   1 
ATOM   1335 C CB  . ARG B 2 125 ? -25.69388 12.36682 -1.06847  1.000 17.83072 ? 457 ARG B CB  1 
ATOM   1336 C CG  . ARG B 2 125 ? -25.43896 13.52765 -0.10739  1.000 20.95370 ? 457 ARG B CG  1 
ATOM   1337 C CD  . ARG B 2 125 ? -26.25173 13.40041 1.18564   1.000 21.84947 ? 457 ARG B CD  1 
ATOM   1338 N NE  . ARG B 2 125 ? -26.14234 14.61090 1.99544   1.000 23.04819 ? 457 ARG B NE  1 
ATOM   1339 C CZ  . ARG B 2 125 ? -25.26346 14.79354 2.96993   1.000 25.82005 ? 457 ARG B CZ  1 
ATOM   1340 N NH1 . ARG B 2 125 ? -24.42219 13.83539 3.33430   1.000 22.20921 ? 457 ARG B NH1 1 
ATOM   1341 N NH2 . ARG B 2 125 ? -25.22465 15.97209 3.59274   1.000 23.15187 ? 457 ARG B NH2 1 
ATOM   1342 N N   . LYS B 2 126 ? -22.59426 12.99513 -2.00762  1.000 22.45580 ? 458 LYS B N   1 
ATOM   1343 C CA  . LYS B 2 126 ? -21.17632 12.64611 -1.91959  1.000 26.41295 ? 458 LYS B CA  1 
ATOM   1344 C C   . LYS B 2 126 ? -20.85750 11.82683 -0.67353  1.000 26.48383 ? 458 LYS B C   1 
ATOM   1345 O O   . LYS B 2 126 ? -19.89445 11.05259 -0.67129  1.000 29.12967 ? 458 LYS B O   1 
ATOM   1346 C CB  . LYS B 2 126 ? -20.32438 13.91672 -1.95545  1.000 30.04349 ? 458 LYS B CB  1 
ATOM   1347 C CG  . LYS B 2 126 ? -20.38331 14.63454 -3.30397  1.000 32.58209 ? 458 LYS B CG  1 
ATOM   1348 C CD  . LYS B 2 126 ? -19.43245 15.83418 -3.37184  1.000 44.23949 ? 458 LYS B CD  1 
ATOM   1349 C CE  . LYS B 2 126 ? -20.01608 17.06715 -2.69305  1.000 41.42182 ? 458 LYS B CE  1 
ATOM   1350 N NZ  . LYS B 2 126 ? -19.70942 17.12744 -1.23272  1.000 51.85407 ? 458 LYS B NZ  1 
ATOM   1351 N N   . SER B 2 127 ? -21.63898 11.97153 0.39084   1.000 21.01225 ? 459 SER B N   1 
ATOM   1352 C CA  . SER B 2 127 ? -21.39998 11.19067 1.59417   1.000 24.44710 ? 459 SER B CA  1 
ATOM   1353 C C   . SER B 2 127 ? -22.73864 10.85556 2.23362   1.000 24.38807 ? 459 SER B C   1 
ATOM   1354 O O   . SER B 2 127 ? -23.77476 11.42767 1.89060   1.000 25.48719 ? 459 SER B O   1 
ATOM   1355 C CB  . SER B 2 127 ? -20.49646 11.93632 2.57269   1.000 28.92945 ? 459 SER B CB  1 
ATOM   1356 O OG  . SER B 2 127 ? -21.16164 13.07386 3.09323   1.000 28.46449 ? 459 SER B OG  1 
ATOM   1357 N N   . ASN B 2 128 ? -22.70532 9.90482  3.16283   1.000 25.32212 ? 460 ASN B N   1 
ATOM   1358 C CA  . ASN B 2 128 ? -23.91219 9.47127  3.84926   1.000 21.92277 ? 460 ASN B CA  1 
ATOM   1359 C C   . ASN B 2 128 ? -24.30870 10.47146 4.92830   1.000 23.82709 ? 460 ASN B C   1 
ATOM   1360 O O   . ASN B 2 128 ? -23.46086 11.12520 5.54015   1.000 22.54466 ? 460 ASN B O   1 
ATOM   1361 C CB  . ASN B 2 128 ? -23.70383 8.09395  4.48238   1.000 24.83821 ? 460 ASN B CB  1 
ATOM   1362 C CG  . ASN B 2 128 ? -23.53708 6.98344  3.45201   1.000 25.32180 ? 460 ASN B CG  1 
ATOM   1363 O OD1 . ASN B 2 128 ? -23.81160 7.16095  2.27550   1.000 26.11204 ? 460 ASN B OD1 1 
ATOM   1364 N ND2 . ASN B 2 128 ? -23.10078 5.82198  3.91100   1.000 29.07480 ? 460 ASN B ND2 1 
ATOM   1365 N N   . LEU B 2 129 ? -25.61269 10.56654 5.17960   1.000 22.04093 ? 461 LEU B N   1 
ATOM   1366 C CA  . LEU B 2 129 ? -26.09808 11.44232 6.23605   1.000 20.07337 ? 461 LEU B CA  1 
ATOM   1367 C C   . LEU B 2 129 ? -25.65794 10.95158 7.60345   1.000 20.75003 ? 461 LEU B C   1 
ATOM   1368 O O   . LEU B 2 129 ? -25.62981 9.74580  7.87312   1.000 22.64293 ? 461 LEU B O   1 
ATOM   1369 C CB  . LEU B 2 129 ? -27.61936 11.51403 6.22180   1.000 21.14870 ? 461 LEU B CB  1 
ATOM   1370 C CG  . LEU B 2 129 ? -28.29540 12.25595 5.08492   1.000 19.27918 ? 461 LEU B CG  1 
ATOM   1371 C CD1 . LEU B 2 129 ? -29.77256 12.11910 5.26957   1.000 16.86023 ? 461 LEU B CD1 1 
ATOM   1372 C CD2 . LEU B 2 129 ? -27.90317 13.70848 5.08122   1.000 21.29025 ? 461 LEU B CD2 1 
ATOM   1373 N N   . LYS B 2 130 ? -25.34517 11.90020 8.48190   1.000 21.59756 ? 462 LYS B N   1 
ATOM   1374 C CA  . LYS B 2 130 ? -25.25184 11.59987 9.89530   1.000 23.70754 ? 462 LYS B CA  1 
ATOM   1375 C C   . LYS B 2 130 ? -26.65405 11.41516 10.47659  1.000 21.01501 ? 462 LYS B C   1 
ATOM   1376 O O   . LYS B 2 130 ? -27.63653 11.92104 9.92002   1.000 20.81284 ? 462 LYS B O   1 
ATOM   1377 C CB  . LYS B 2 130 ? -24.50608 12.72132 10.61804  1.000 25.11649 ? 462 LYS B CB  1 
ATOM   1378 C CG  . LYS B 2 130 ? -23.05665 12.86286 10.17826  1.000 25.98645 ? 462 LYS B CG  1 
ATOM   1379 C CD  . LYS B 2 130 ? -22.45510 14.14636 10.74081  1.000 41.37230 ? 462 LYS B CD  1 
ATOM   1380 C CE  . LYS B 2 130 ? -23.24982 15.36648 10.28317  1.000 41.16569 ? 462 LYS B CE  1 
ATOM   1381 N NZ  . LYS B 2 130 ? -22.64659 16.65474 10.74560  1.000 47.25518 ? 462 LYS B NZ  1 
ATOM   1382 N N   . PRO B 2 131 ? -26.77377 10.68447 11.58878  1.000 22.44772 ? 463 PRO B N   1 
ATOM   1383 C CA  . PRO B 2 131 ? -28.09798 10.46595 12.19019  1.000 21.91586 ? 463 PRO B CA  1 
ATOM   1384 C C   . PRO B 2 131 ? -28.82423 11.78252 12.43069  1.000 23.23668 ? 463 PRO B C   1 
ATOM   1385 O O   . PRO B 2 131 ? -28.24892 12.74404 12.94042  1.000 21.57972 ? 463 PRO B O   1 
ATOM   1386 C CB  . PRO B 2 131 ? -27.77313 9.74293  13.50300  1.000 23.01449 ? 463 PRO B CB  1 
ATOM   1387 C CG  . PRO B 2 131 ? -26.49498 9.02588  13.20845  1.000 26.58838 ? 463 PRO B CG  1 
ATOM   1388 C CD  . PRO B 2 131 ? -25.71380 9.97161  12.32824  1.000 26.00976 ? 463 PRO B CD  1 
ATOM   1389 N N   . PHE B 2 132 ? -30.08508 11.83201 11.99354  1.000 19.04674 ? 464 PHE B N   1 
ATOM   1390 C CA  . PHE B 2 132 ? -30.97927 12.98257 12.11337  1.000 21.16252 ? 464 PHE B CA  1 
ATOM   1391 C C   . PHE B 2 132 ? -30.49232 14.20573 11.34352  1.000 20.45937 ? 464 PHE B C   1 
ATOM   1392 O O   . PHE B 2 132 ? -30.98273 15.30996 11.57476  1.000 20.34697 ? 464 PHE B O   1 
ATOM   1393 C CB  . PHE B 2 132 ? -31.23344 13.35468 13.58057  1.000 20.97837 ? 464 PHE B CB  1 
ATOM   1394 C CG  . PHE B 2 132 ? -31.93006 12.27454 14.35838  1.000 22.59095 ? 464 PHE B CG  1 
ATOM   1395 C CD1 . PHE B 2 132 ? -33.16620 11.80471 13.95504  1.000 22.90341 ? 464 PHE B CD1 1 
ATOM   1396 C CD2 . PHE B 2 132 ? -31.34226 11.72211 15.48404  1.000 24.03898 ? 464 PHE B CD2 1 
ATOM   1397 C CE1 . PHE B 2 132 ? -33.81121 10.80712 14.66661  1.000 23.04897 ? 464 PHE B CE1 1 
ATOM   1398 C CE2 . PHE B 2 132 ? -31.97953 10.72250 16.19699  1.000 23.87950 ? 464 PHE B CE2 1 
ATOM   1399 C CZ  . PHE B 2 132 ? -33.21395 10.27101 15.79167  1.000 26.03334 ? 464 PHE B CZ  1 
ATOM   1400 N N   . GLU B 2 133 ? -29.55383 14.03879 10.41554  1.000 22.51249 ? 465 GLU B N   1 
ATOM   1401 C CA  . GLU B 2 133 ? -29.18277 15.13033 9.52589   1.000 21.96327 ? 465 GLU B CA  1 
ATOM   1402 C C   . GLU B 2 133 ? -30.24491 15.30913 8.44847   1.000 24.37321 ? 465 GLU B C   1 
ATOM   1403 O O   . GLU B 2 133 ? -30.90190 14.35093 8.02228   1.000 19.90723 ? 465 GLU B O   1 
ATOM   1404 C CB  . GLU B 2 133 ? -27.80863 14.87241 8.88915   1.000 24.43004 ? 465 GLU B CB  1 
ATOM   1405 C CG  . GLU B 2 133 ? -27.25008 16.06675 8.14270   1.000 23.69009 ? 465 GLU B CG  1 
ATOM   1406 C CD  . GLU B 2 133 ? -25.89389 15.81940 7.49608   1.000 27.66905 ? 465 GLU B CD  1 
ATOM   1407 O OE1 . GLU B 2 133 ? -25.32310 14.70138 7.61280   1.000 24.03920 ? 465 GLU B OE1 1 
ATOM   1408 O OE2 . GLU B 2 133 ? -25.40003 16.77119 6.85947   1.000 29.95200 ? 465 GLU B OE2 1 
ATOM   1409 N N   . ARG B 2 134 ? -30.43113 16.55725 8.02379   1.000 20.12633 ? 466 ARG B N   1 
ATOM   1410 C CA  . ARG B 2 134 ? -31.42424 16.90125 7.01374   1.000 19.10470 ? 466 ARG B CA  1 
ATOM   1411 C C   . ARG B 2 134 ? -30.72931 17.70946 5.92681   1.000 24.21363 ? 466 ARG B C   1 
ATOM   1412 O O   . ARG B 2 134 ? -30.12065 18.74113 6.22113   1.000 23.43122 ? 466 ARG B O   1 
ATOM   1413 C CB  . ARG B 2 134 ? -32.57254 17.69334 7.64348   1.000 21.35550 ? 466 ARG B CB  1 
ATOM   1414 C CG  . ARG B 2 134 ? -33.74265 18.05130 6.74971   1.000 20.48928 ? 466 ARG B CG  1 
ATOM   1415 C CD  . ARG B 2 134 ? -34.86862 18.58293 7.65545   1.000 24.59460 ? 466 ARG B CD  1 
ATOM   1416 N NE  . ARG B 2 134 ? -36.07366 18.99880 6.95122   1.000 29.01094 ? 466 ARG B NE  1 
ATOM   1417 C CZ  . ARG B 2 134 ? -36.32049 20.23022 6.50932   1.000 37.02190 ? 466 ARG B CZ  1 
ATOM   1418 N NH1 . ARG B 2 134 ? -35.42306 21.20127 6.61026   1.000 34.86071 ? 466 ARG B NH1 1 
ATOM   1419 N NH2 . ARG B 2 134 ? -37.50416 20.49816 5.95666   1.000 33.25299 ? 466 ARG B NH2 1 
ATOM   1420 N N   . ASP B 2 135 ? -30.79918 17.23423 4.67841   1.000 20.66419 ? 467 ASP B N   1 
ATOM   1421 C CA  . ASP B 2 135 ? -30.15072 17.89427 3.54242   1.000 20.41734 ? 467 ASP B CA  1 
ATOM   1422 C C   . ASP B 2 135 ? -31.23552 18.29773 2.55488   1.000 20.80441 ? 467 ASP B C   1 
ATOM   1423 O O   . ASP B 2 135 ? -31.84389 17.43306 1.91356   1.000 20.66536 ? 467 ASP B O   1 
ATOM   1424 C CB  . ASP B 2 135 ? -29.12471 16.96007 2.89925   1.000 20.30631 ? 467 ASP B CB  1 
ATOM   1425 C CG  . ASP B 2 135 ? -28.34945 17.60651 1.75814   1.000 20.52543 ? 467 ASP B CG  1 
ATOM   1426 O OD1 . ASP B 2 135 ? -28.63379 18.76546 1.39966   1.000 22.46251 ? 467 ASP B OD1 1 
ATOM   1427 O OD2 . ASP B 2 135 ? -27.43729 16.94106 1.22834   1.000 22.55614 ? 467 ASP B OD2 1 
ATOM   1428 N N   . ILE B 2 136 ? -31.48972 19.60072 2.43312   1.000 19.49530 ? 468 ILE B N   1 
ATOM   1429 C CA  . ILE B 2 136 ? -32.49673 20.09263 1.49907   1.000 19.86508 ? 468 ILE B CA  1 
ATOM   1430 C C   . ILE B 2 136 ? -31.85657 20.82696 0.31820   1.000 22.33145 ? 468 ILE B C   1 
ATOM   1431 O O   . ILE B 2 136 ? -32.54490 21.53200 -0.42705  1.000 17.94531 ? 468 ILE B O   1 
ATOM   1432 C CB  . ILE B 2 136 ? -33.54444 20.97165 2.20779   1.000 21.17842 ? 468 ILE B CB  1 
ATOM   1433 C CG1 . ILE B 2 136 ? -32.92118 22.26885 2.73719   1.000 22.37525 ? 468 ILE B CG1 1 
ATOM   1434 C CG2 . ILE B 2 136 ? -34.21970 20.18656 3.33075   1.000 22.69466 ? 468 ILE B CG2 1 
ATOM   1435 C CD1 . ILE B 2 136 ? -33.95266 23.22850 3.30816   1.000 27.11096 ? 468 ILE B CD1 1 
ATOM   1436 N N   . SER B 2 137 ? -30.55154 20.66468 0.13751   1.000 19.37100 ? 469 SER B N   1 
ATOM   1437 C CA  . SER B 2 137 ? -29.84102 21.36214 -0.91739  1.000 20.57836 ? 469 SER B CA  1 
ATOM   1438 C C   . SER B 2 137 ? -30.19479 20.76790 -2.27474  1.000 23.18366 ? 469 SER B C   1 
ATOM   1439 O O   . SER B 2 137 ? -30.63413 19.61777 -2.38537  1.000 20.72084 ? 469 SER B O   1 
ATOM   1440 C CB  . SER B 2 137 ? -28.33303 21.28849 -0.68075  1.000 23.46730 ? 469 SER B CB  1 
ATOM   1441 O OG  . SER B 2 137 ? -27.86473 19.95151 -0.72780  1.000 23.39815 ? 469 SER B OG  1 
ATOM   1442 N N   . THR B 2 138 ? -30.01156 21.56999 -3.32231  1.000 19.50662 ? 470 THR B N   1 
ATOM   1443 C CA  . THR B 2 138 ? -30.34586 21.12743 -4.67322  1.000 21.55013 ? 470 THR B CA  1 
ATOM   1444 C C   . THR B 2 138 ? -29.21511 21.42466 -5.64760  1.000 20.33037 ? 470 THR B C   1 
ATOM   1445 O O   . THR B 2 138 ? -29.45415 21.76693 -6.80593  1.000 23.01307 ? 470 THR B O   1 
ATOM   1446 C CB  . THR B 2 138 ? -31.64998 21.75677 -5.16200  1.000 23.54328 ? 470 THR B CB  1 
ATOM   1447 O OG1 . THR B 2 138 ? -31.56695 23.18265 -5.05500  1.000 24.64757 ? 470 THR B OG1 1 
ATOM   1448 C CG2 . THR B 2 138 ? -32.86098 21.23290 -4.34893  1.000 24.27953 ? 470 THR B CG2 1 
ATOM   1449 N N   . GLU B 2 139 ? -27.97215 21.26235 -5.20525  1.000 20.17587 ? 471 GLU B N   1 
ATOM   1450 C CA  . GLU B 2 139 ? -26.82558 21.44671 -6.08585  1.000 22.17654 ? 471 GLU B CA  1 
ATOM   1451 C C   . GLU B 2 139 ? -26.75655 20.32259 -7.10624  1.000 24.94946 ? 471 GLU B C   1 
ATOM   1452 O O   . GLU B 2 139 ? -26.95878 19.15333 -6.76824  1.000 18.88074 ? 471 GLU B O   1 
ATOM   1453 C CB  . GLU B 2 139 ? -25.52997 21.47052 -5.28604  1.000 28.35381 ? 471 GLU B CB  1 
ATOM   1454 C CG  . GLU B 2 139 ? -25.42067 22.64010 -4.32909  1.000 41.77035 ? 471 GLU B CG  1 
ATOM   1455 C CD  . GLU B 2 139 ? -24.45696 23.69040 -4.84211  1.000 54.79156 ? 471 GLU B CD  1 
ATOM   1456 O OE1 . GLU B 2 139 ? -23.37244 23.30004 -5.33421  1.000 59.57154 ? 471 GLU B OE1 1 
ATOM   1457 O OE2 . GLU B 2 139 ? -24.78835 24.89584 -4.76859  1.000 60.44199 ? 471 GLU B OE2 1 
ATOM   1458 N N   . ILE B 2 140 ? -26.45456 20.68420 -8.35782  1.000 23.30897 ? 472 ILE B N   1 
ATOM   1459 C CA  . ILE B 2 140 ? -26.28028 19.67466 -9.39726  1.000 19.09534 ? 472 ILE B CA  1 
ATOM   1460 C C   . ILE B 2 140 ? -25.13876 18.75821 -8.99283  1.000 22.44238 ? 472 ILE B C   1 
ATOM   1461 O O   . ILE B 2 140 ? -24.05795 19.21620 -8.59723  1.000 21.32098 ? 472 ILE B O   1 
ATOM   1462 C CB  . ILE B 2 140 ? -26.03003 20.33696 -10.76182 1.000 23.13237 ? 472 ILE B CB  1 
ATOM   1463 C CG1 . ILE B 2 140 ? -27.18244 21.28599 -11.12292 1.000 22.36658 ? 472 ILE B CG1 1 
ATOM   1464 C CG2 . ILE B 2 140 ? -25.83771 19.28661 -11.84683 1.000 22.82447 ? 472 ILE B CG2 1 
ATOM   1465 C CD1 . ILE B 2 140 ? -28.58320 20.70287 -10.92588 1.000 21.69863 ? 472 ILE B CD1 1 
ATOM   1466 N N   . TYR B 2 141 ? -25.37823 17.45363 -9.07949  1.000 19.60796 ? 473 TYR B N   1 
ATOM   1467 C CA  . TYR B 2 141 ? -24.45737 16.45973 -8.54339  1.000 19.35928 ? 473 TYR B CA  1 
ATOM   1468 C C   . TYR B 2 141 ? -23.46710 16.00462 -9.61013  1.000 19.46549 ? 473 TYR B C   1 
ATOM   1469 O O   . TYR B 2 141 ? -23.86811 15.58540 -10.69991 1.000 17.68772 ? 473 TYR B O   1 
ATOM   1470 C CB  . TYR B 2 141 ? -25.24149 15.26609 -8.00580  1.000 17.28713 ? 473 TYR B CB  1 
ATOM   1471 C CG  . TYR B 2 141 ? -24.35175 14.20473 -7.43041  1.000 19.15774 ? 473 TYR B CG  1 
ATOM   1472 C CD1 . TYR B 2 141 ? -23.91787 14.27621 -6.12181  1.000 22.28416 ? 473 TYR B CD1 1 
ATOM   1473 C CD2 . TYR B 2 141 ? -23.93362 13.13751 -8.20746  1.000 21.74090 ? 473 TYR B CD2 1 
ATOM   1474 C CE1 . TYR B 2 141 ? -23.08936 13.30336 -5.59139  1.000 25.15386 ? 473 TYR B CE1 1 
ATOM   1475 C CE2 . TYR B 2 141 ? -23.11625 12.16499 -7.69705  1.000 23.48060 ? 473 TYR B CE2 1 
ATOM   1476 C CZ  . TYR B 2 141 ? -22.69159 12.25126 -6.39009  1.000 26.17370 ? 473 TYR B CZ  1 
ATOM   1477 O OH  . TYR B 2 141 ? -21.87312 11.27441 -5.88255  1.000 32.68871 ? 473 TYR B OH  1 
ATOM   1478 N N   . GLN B 2 142 ? -22.17934 16.06612 -9.28236  1.000 20.51879 ? 474 GLN B N   1 
ATOM   1479 C CA  . GLN B 2 142 ? -21.10794 15.68154 -10.20354 1.000 20.05607 ? 474 GLN B CA  1 
ATOM   1480 C C   . GLN B 2 142 ? -20.85966 14.18248 -10.08364 1.000 20.28008 ? 474 GLN B C   1 
ATOM   1481 O O   . GLN B 2 142 ? -20.17660 13.71671 -9.15819  1.000 19.69440 ? 474 GLN B O   1 
ATOM   1482 C CB  . GLN B 2 142 ? -19.83058 16.45898 -9.90879  1.000 21.21800 ? 474 GLN B CB  1 
ATOM   1483 C CG  . GLN B 2 142 ? -18.71657 16.12619 -10.89703 1.000 23.10642 ? 474 GLN B CG  1 
ATOM   1484 C CD  . GLN B 2 142 ? -17.40268 16.75046 -10.51747 1.000 25.39445 ? 474 GLN B CD  1 
ATOM   1485 O OE1 . GLN B 2 142 ? -17.36283 17.83556 -9.93087  1.000 23.83012 ? 474 GLN B OE1 1 
ATOM   1486 N NE2 . GLN B 2 142 ? -16.31371 16.07028 -10.83727 1.000 23.61201 ? 474 GLN B NE2 1 
ATOM   1487 N N   . ALA B 2 143 ? -21.40386 13.42154 -11.02886 1.000 21.22931 ? 475 ALA B N   1 
ATOM   1488 C CA  . ALA B 2 143 ? -21.20945 11.98028 -11.04251 1.000 21.80931 ? 475 ALA B CA  1 
ATOM   1489 C C   . ALA B 2 143 ? -19.98094 11.55869 -11.83288 1.000 23.59413 ? 475 ALA B C   1 
ATOM   1490 O O   . ALA B 2 143 ? -19.50738 10.43152 -11.66028 1.000 25.90310 ? 475 ALA B O   1 
ATOM   1491 C CB  . ALA B 2 143 ? -22.45440 11.29085 -11.60786 1.000 22.18134 ? 475 ALA B CB  1 
ATOM   1492 N N   . GLY B 2 144 ? -19.44267 12.43142 -12.67380 1.000 23.76733 ? 476 GLY B N   1 
ATOM   1493 C CA  . GLY B 2 144 ? -18.29694 12.07672 -13.48779 1.000 25.15135 ? 476 GLY B CA  1 
ATOM   1494 C C   . GLY B 2 144 ? -17.05586 12.92001 -13.25698 1.000 25.79659 ? 476 GLY B C   1 
ATOM   1495 O O   . GLY B 2 144 ? -16.91335 13.58682 -12.22560 1.000 26.40109 ? 476 GLY B O   1 
ATOM   1496 N N   . SER B 2 145 ? -16.14260 12.90138 -14.22950 1.000 25.74002 ? 477 SER B N   1 
ATOM   1497 C CA  . SER B 2 145 ? -14.82749 13.49869 -14.04298 1.000 27.87901 ? 477 SER B CA  1 
ATOM   1498 C C   . SER B 2 145 ? -14.85022 15.01857 -14.11370 1.000 26.63252 ? 477 SER B C   1 
ATOM   1499 O O   . SER B 2 145 ? -13.94246 15.65936 -13.57465 1.000 30.19148 ? 477 SER B O   1 
ATOM   1500 C CB  . SER B 2 145 ? -13.85587 12.96431 -15.10055 1.000 26.62477 ? 477 SER B CB  1 
ATOM   1501 O OG  . SER B 2 145 ? -14.31609 13.32244 -16.38992 1.000 31.27956 ? 477 SER B OG  1 
ATOM   1502 N N   . LYS B 2 146 ? -15.84009 15.59705 -14.75899 1.000 23.66507 ? 478 LYS B N   1 
ATOM   1503 C CA  . LYS B 2 146 ? -15.85875 17.02355 -15.05456 1.000 27.50008 ? 478 LYS B CA  1 
ATOM   1504 C C   . LYS B 2 146 ? -16.86210 17.75909 -14.17610 1.000 27.06154 ? 478 LYS B C   1 
ATOM   1505 O O   . LYS B 2 146 ? -17.95212 17.23663 -13.90468 1.000 22.84123 ? 478 LYS B O   1 
ATOM   1506 C CB  . LYS B 2 146 ? -16.21155 17.27568 -16.52923 1.000 28.82746 ? 478 LYS B CB  1 
ATOM   1507 C CG  . LYS B 2 146 ? -15.23969 16.63872 -17.52751 1.000 31.04567 ? 478 LYS B CG  1 
ATOM   1508 C CD  . LYS B 2 146 ? -13.83476 17.18344 -17.34345 1.000 29.60972 ? 478 LYS B CD  1 
ATOM   1509 C CE  . LYS B 2 146 ? -12.90461 16.72610 -18.46600 1.000 36.70629 ? 478 LYS B CE  1 
ATOM   1510 N NZ  . LYS B 2 146 ? -12.46376 15.31787 -18.28119 1.000 37.23050 ? 478 LYS B NZ  1 
ATOM   1511 N N   . PRO B 2 147 ? -16.53784 18.97914 -13.74691 1.000 28.43883 ? 479 PRO B N   1 
ATOM   1512 C CA  . PRO B 2 147 ? -17.45907 19.72348 -12.87785 1.000 23.70732 ? 479 PRO B CA  1 
ATOM   1513 C C   . PRO B 2 147 ? -18.70586 20.16712 -13.62378 1.000 23.73861 ? 479 PRO B C   1 
ATOM   1514 O O   . PRO B 2 147 ? -18.70576 20.33896 -14.84399 1.000 24.21407 ? 479 PRO B O   1 
ATOM   1515 C CB  . PRO B 2 147 ? -16.62083 20.92758 -12.42082 1.000 25.11469 ? 479 PRO B CB  1 
ATOM   1516 C CG  . PRO B 2 147 ? -15.64642 21.14333 -13.54006 1.000 25.71244 ? 479 PRO B CG  1 
ATOM   1517 C CD  . PRO B 2 147 ? -15.32390 19.75725 -14.06920 1.000 25.76269 ? 479 PRO B CD  1 
ATOM   1518 N N   . CYS B 2 148 ? -19.79027 20.33992 -12.86761 1.000 21.35975 ? 480 CYS B N   1 
ATOM   1519 C CA  . CYS B 2 148 ? -21.07975 20.66444 -13.45646 1.000 21.75915 ? 480 CYS B CA  1 
ATOM   1520 C C   . CYS B 2 148 ? -21.33263 22.15719 -13.57165 1.000 23.06503 ? 480 CYS B C   1 
ATOM   1521 O O   . CYS B 2 148 ? -22.13918 22.56267 -14.40809 1.000 20.78310 ? 480 CYS B O   1 
ATOM   1522 C CB  . CYS B 2 148 ? -22.20155 20.02510 -12.64151 1.000 27.58085 ? 480 CYS B CB  1 
ATOM   1523 S SG  . CYS B 2 148 ? -21.95026 18.24104 -12.51476 1.000 31.26837 ? 480 CYS B SG  1 
ATOM   1524 N N   . ASN B 2 149 ? -20.68249 22.97316 -12.74588 1.000 26.62811 ? 481 ASN B N   1 
ATOM   1525 C CA  . ASN B 2 149 ? -20.85066 24.42564 -12.79574 1.000 27.56909 ? 481 ASN B CA  1 
ATOM   1526 C C   . ASN B 2 149 ? -22.30999 24.83654 -12.62445 1.000 25.99092 ? 481 ASN B C   1 
ATOM   1527 O O   . ASN B 2 149 ? -22.76176 25.81561 -13.21678 1.000 29.48521 ? 481 ASN B O   1 
ATOM   1528 C CB  . ASN B 2 149 ? -20.28443 24.98440 -14.10394 1.000 27.28160 ? 481 ASN B CB  1 
ATOM   1529 C CG  . ASN B 2 149 ? -18.86342 24.50962 -14.36976 1.000 29.82080 ? 481 ASN B CG  1 
ATOM   1530 O OD1 . ASN B 2 149 ? -17.98404 24.64240 -13.51150 1.000 25.43457 ? 481 ASN B OD1 1 
ATOM   1531 N ND2 . ASN B 2 149 ? -18.63622 23.93074 -15.55150 1.000 28.73045 ? 481 ASN B ND2 1 
ATOM   1532 N N   . GLY B 2 150 ? -23.07628 24.08232 -11.84229 1.000 27.02618 ? 482 GLY B N   1 
ATOM   1533 C CA  . GLY B 2 150 ? -24.47839 24.41054 -11.63620 1.000 26.42748 ? 482 GLY B CA  1 
ATOM   1534 C C   . GLY B 2 150 ? -25.40913 24.09318 -12.78595 1.000 26.79783 ? 482 GLY B C   1 
ATOM   1535 O O   . GLY B 2 150 ? -26.56810 24.52806 -12.75998 1.000 26.67948 ? 482 GLY B O   1 
ATOM   1536 N N   . VAL B 2 151 ? -24.95590 23.33470 -13.78497 1.000 21.04091 ? 483 VAL B N   1 
ATOM   1537 C CA  . VAL B 2 151 ? -25.71397 23.07640 -15.00281 1.000 22.70880 ? 483 VAL B CA  1 
ATOM   1538 C C   . VAL B 2 151 ? -25.92340 21.57364 -15.12863 1.000 24.65984 ? 483 VAL B C   1 
ATOM   1539 O O   . VAL B 2 151 ? -24.95763 20.80220 -15.05134 1.000 23.77107 ? 483 VAL B O   1 
ATOM   1540 C CB  . VAL B 2 151 ? -24.98813 23.61586 -16.25303 1.000 25.89515 ? 483 VAL B CB  1 
ATOM   1541 C CG1 . VAL B 2 151 ? -25.83213 23.38853 -17.50462 1.000 32.53616 ? 483 VAL B CG1 1 
ATOM   1542 C CG2 . VAL B 2 151 ? -24.63544 25.09281 -16.08694 1.000 29.60484 ? 483 VAL B CG2 1 
ATOM   1543 N N   . GLU B 2 152 ? -27.17534 21.16562 -15.32660 1.000 24.38404 ? 484 GLU B N   1 
ATOM   1544 C CA  . GLU B 2 152 ? -27.47532 19.76612 -15.59907 1.000 25.71967 ? 484 GLU B CA  1 
ATOM   1545 C C   . GLU B 2 152 ? -26.91358 19.36539 -16.95686 1.000 28.43542 ? 484 GLU B C   1 
ATOM   1546 O O   . GLU B 2 152 ? -26.94602 20.14487 -17.91069 1.000 24.07064 ? 484 GLU B O   1 
ATOM   1547 C CB  . GLU B 2 152 ? -28.98335 19.52309 -15.57998 1.000 27.75145 ? 484 GLU B CB  1 
ATOM   1548 C CG  . GLU B 2 152 ? -29.65013 19.77669 -14.24370 1.000 26.18308 ? 484 GLU B CG  1 
ATOM   1549 C CD  . GLU B 2 152 ? -31.15439 19.62568 -14.32647 1.000 31.38567 ? 484 GLU B CD  1 
ATOM   1550 O OE1 . GLU B 2 152 ? -31.63130 18.50309 -14.61424 1.000 31.28134 ? 484 GLU B OE1 1 
ATOM   1551 O OE2 . GLU B 2 152 ? -31.85354 20.63697 -14.12379 1.000 37.33739 ? 484 GLU B OE2 1 
ATOM   1552 N N   . GLY B 2 153 ? -26.39676 18.14210 -17.04051 1.000 25.61141 ? 485 GLY B N   1 
ATOM   1553 C CA  . GLY B 2 153 ? -25.90002 17.62908 -18.30357 1.000 27.10834 ? 485 GLY B CA  1 
ATOM   1554 C C   . GLY B 2 153 ? -25.29430 16.24835 -18.16050 1.000 27.48494 ? 485 GLY B C   1 
ATOM   1555 O O   . GLY B 2 153 ? -25.73512 15.44988 -17.32665 1.000 23.24671 ? 485 GLY B O   1 
ATOM   1556 N N   . PHE B 2 154 ? -24.26322 15.96359 -18.95212 1.000 24.56757 ? 486 PHE B N   1 
ATOM   1557 C CA  . PHE B 2 154 ? -23.64192 14.64728 -18.92464 1.000 27.50070 ? 486 PHE B CA  1 
ATOM   1558 C C   . PHE B 2 154 ? -23.02363 14.36975 -17.55901 1.000 22.91637 ? 486 PHE B C   1 
ATOM   1559 O O   . PHE B 2 154 ? -22.09915 15.06972 -17.12978 1.000 23.96236 ? 486 PHE B O   1 
ATOM   1560 C CB  . PHE B 2 154 ? -22.58674 14.55320 -20.03229 1.000 26.43986 ? 486 PHE B CB  1 
ATOM   1561 C CG  . PHE B 2 154 ? -21.96709 13.18951 -20.16485 1.000 25.02995 ? 486 PHE B CG  1 
ATOM   1562 C CD1 . PHE B 2 154 ? -22.65407 12.15821 -20.78786 1.000 27.10233 ? 486 PHE B CD1 1 
ATOM   1563 C CD2 . PHE B 2 154 ? -20.70474 12.94076 -19.66846 1.000 26.33459 ? 486 PHE B CD2 1 
ATOM   1564 C CE1 . PHE B 2 154 ? -22.08799 10.89985 -20.89950 1.000 26.03814 ? 486 PHE B CE1 1 
ATOM   1565 C CE2 . PHE B 2 154 ? -20.12927 11.68644 -19.78481 1.000 29.57451 ? 486 PHE B CE2 1 
ATOM   1566 C CZ  . PHE B 2 154 ? -20.82154 10.66812 -20.40411 1.000 24.49743 ? 486 PHE B CZ  1 
ATOM   1567 N N   . ASN B 2 155 ? -23.52875 13.33437 -16.87592 1.000 21.00774 ? 487 ASN B N   1 
ATOM   1568 C CA  . ASN B 2 155 ? -23.03883 12.95563 -15.55199 1.000 18.34649 ? 487 ASN B CA  1 
ATOM   1569 C C   . ASN B 2 155 ? -23.13447 14.11643 -14.55666 1.000 20.09459 ? 487 ASN B C   1 
ATOM   1570 O O   . ASN B 2 155 ? -22.33936 14.21428 -13.62139 1.000 20.28611 ? 487 ASN B O   1 
ATOM   1571 C CB  . ASN B 2 155 ? -21.59722 12.43077 -15.61678 1.000 22.11340 ? 487 ASN B CB  1 
ATOM   1572 C CG  . ASN B 2 155 ? -21.51751 10.95471 -16.00056 1.000 22.69444 ? 487 ASN B CG  1 
ATOM   1573 O OD1 . ASN B 2 155 ? -20.84681 10.17192 -15.33174 1.000 32.05241 ? 487 ASN B OD1 1 
ATOM   1574 N ND2 . ASN B 2 155 ? -22.21769 10.57172 -17.06291 1.000 26.36677 ? 487 ASN B ND2 1 
ATOM   1575 N N   . CYS B 2 156 ? -24.11291 14.99466 -14.76154 1.000 23.14522 ? 488 CYS B N   1 
ATOM   1576 C CA  . CYS B 2 156 ? -24.34004 16.17069 -13.92116 1.000 20.19658 ? 488 CYS B CA  1 
ATOM   1577 C C   . CYS B 2 156 ? -25.84216 16.22602 -13.66320 1.000 20.20455 ? 488 CYS B C   1 
ATOM   1578 O O   . CYS B 2 156 ? -26.60696 16.69362 -14.50819 1.000 21.80411 ? 488 CYS B O   1 
ATOM   1579 C CB  . CYS B 2 156 ? -23.82210 17.42630 -14.61972 1.000 23.16272 ? 488 CYS B CB  1 
ATOM   1580 S SG  . CYS B 2 156 ? -22.03745 17.55690 -14.46917 1.000 24.19919 ? 488 CYS B SG  1 
ATOM   1581 N N   . TYR B 2 157 ? -26.26845 15.73934 -12.50193 1.000 20.96853 ? 489 TYR B N   1 
ATOM   1582 C CA  . TYR B 2 157 ? -27.67247 15.41587 -12.28976 1.000 19.38636 ? 489 TYR B CA  1 
ATOM   1583 C C   . TYR B 2 157 ? -28.28900 16.26235 -11.19004 1.000 16.34455 ? 489 TYR B C   1 
ATOM   1584 O O   . TYR B 2 157 ? -27.67150 16.49482 -10.14408 1.000 17.84752 ? 489 TYR B O   1 
ATOM   1585 C CB  . TYR B 2 157 ? -27.83450 13.93958 -11.93538 1.000 19.47839 ? 489 TYR B CB  1 
ATOM   1586 C CG  . TYR B 2 157 ? -27.19154 13.01884 -12.95198 1.000 18.83966 ? 489 TYR B CG  1 
ATOM   1587 C CD1 . TYR B 2 157 ? -27.51067 13.11499 -14.31055 1.000 20.91898 ? 489 TYR B CD1 1 
ATOM   1588 C CD2 . TYR B 2 157 ? -26.25772 12.06922 -12.55812 1.000 20.08752 ? 489 TYR B CD2 1 
ATOM   1589 C CE1 . TYR B 2 157 ? -26.91986 12.27024 -15.25908 1.000 21.83370 ? 489 TYR B CE1 1 
ATOM   1590 C CE2 . TYR B 2 157 ? -25.66181 11.21632 -13.49171 1.000 21.56040 ? 489 TYR B CE2 1 
ATOM   1591 C CZ  . TYR B 2 157 ? -25.99660 11.32030 -14.83615 1.000 24.13934 ? 489 TYR B CZ  1 
ATOM   1592 O OH  . TYR B 2 157 ? -25.39630 10.47188 -15.75832 1.000 22.66371 ? 489 TYR B OH  1 
ATOM   1593 N N   . PHE B 2 158 ? -29.51831 16.69048 -11.42224 1.000 18.06189 ? 490 PHE B N   1 
ATOM   1594 C CA  . PHE B 2 158 ? -30.31955 17.19585 -10.32152 1.000 20.90887 ? 490 PHE B CA  1 
ATOM   1595 C C   . PHE B 2 158 ? -30.41927 16.10333 -9.25976  1.000 20.51953 ? 490 PHE B C   1 
ATOM   1596 O O   . PHE B 2 158 ? -30.67323 14.93511 -9.59911  1.000 19.40900 ? 490 PHE B O   1 
ATOM   1597 C CB  . PHE B 2 158 ? -31.71069 17.61964 -10.79093 1.000 20.55660 ? 490 PHE B CB  1 
ATOM   1598 C CG  . PHE B 2 158 ? -32.44012 18.46028 -9.77720  1.000 24.46838 ? 490 PHE B CG  1 
ATOM   1599 C CD1 . PHE B 2 158 ? -32.13189 19.80492 -9.63117  1.000 23.76318 ? 490 PHE B CD1 1 
ATOM   1600 C CD2 . PHE B 2 158 ? -33.40248 17.90027 -8.95904  1.000 19.43230 ? 490 PHE B CD2 1 
ATOM   1601 C CE1 . PHE B 2 158 ? -32.77312 20.58504 -8.68956  1.000 24.42324 ? 490 PHE B CE1 1 
ATOM   1602 C CE2 . PHE B 2 158 ? -34.06510 18.67172 -8.01495  1.000 24.29949 ? 490 PHE B CE2 1 
ATOM   1603 C CZ  . PHE B 2 158 ? -33.74162 20.01348 -7.87077  1.000 24.74287 ? 490 PHE B CZ  1 
ATOM   1604 N N   . PRO B 2 159 ? -30.20540 16.42289 -7.98115  1.000 19.98297 ? 491 PRO B N   1 
ATOM   1605 C CA  . PRO B 2 159 ? -29.98329 15.35895 -6.98966  1.000 18.17264 ? 491 PRO B CA  1 
ATOM   1606 C C   . PRO B 2 159 ? -31.24565 14.69824 -6.46982  1.000 19.21799 ? 491 PRO B C   1 
ATOM   1607 O O   . PRO B 2 159 ? -31.13780 13.64868 -5.82018  1.000 18.75834 ? 491 PRO B O   1 
ATOM   1608 C CB  . PRO B 2 159 ? -29.24194 16.08884 -5.86193  1.000 18.96479 ? 491 PRO B CB  1 
ATOM   1609 C CG  . PRO B 2 159 ? -29.72032 17.50092 -5.95675  1.000 18.28156 ? 491 PRO B CG  1 
ATOM   1610 C CD  . PRO B 2 159 ? -29.90630 17.76508 -7.43533  1.000 19.42312 ? 491 PRO B CD  1 
ATOM   1611 N N   . LEU B 2 160 ? -32.41859 15.26464 -6.72679  1.000 16.79415 ? 492 LEU B N   1 
ATOM   1612 C CA  . LEU B 2 160 ? -33.68569 14.72031 -6.27125  1.000 16.23477 ? 492 LEU B CA  1 
ATOM   1613 C C   . LEU B 2 160 ? -34.43409 14.09677 -7.43904  1.000 22.45463 ? 492 LEU B C   1 
ATOM   1614 O O   . LEU B 2 160 ? -34.30314 14.53376 -8.58566  1.000 22.31120 ? 492 LEU B O   1 
ATOM   1615 C CB  . LEU B 2 160 ? -34.56769 15.80142 -5.64366  1.000 19.51132 ? 492 LEU B CB  1 
ATOM   1616 C CG  . LEU B 2 160 ? -33.91784 16.71462 -4.60630  1.000 18.56293 ? 492 LEU B CG  1 
ATOM   1617 C CD1 . LEU B 2 160 ? -34.92743 17.74161 -4.10616  1.000 19.55861 ? 492 LEU B CD1 1 
ATOM   1618 C CD2 . LEU B 2 160 ? -33.30748 15.92520 -3.45023  1.000 15.94690 ? 492 LEU B CD2 1 
ATOM   1619 N N   . GLN B 2 161 ? -35.22376 13.07551 -7.12260  1.000 19.12327 ? 493 GLN B N   1 
ATOM   1620 C CA  . GLN B 2 161 ? -36.06113 12.37134 -8.07582  1.000 20.87109 ? 493 GLN B CA  1 
ATOM   1621 C C   . GLN B 2 161 ? -37.45978 12.27138 -7.49843  1.000 23.15741 ? 493 GLN B C   1 
ATOM   1622 O O   . GLN B 2 161 ? -37.63178 12.12330 -6.28752  1.000 20.04784 ? 493 GLN B O   1 
ATOM   1623 C CB  . GLN B 2 161 ? -35.53192 10.95800 -8.35934  1.000 21.50212 ? 493 GLN B CB  1 
ATOM   1624 C CG  . GLN B 2 161 ? -34.50280 10.88731 -9.43395  1.000 26.13188 ? 493 GLN B CG  1 
ATOM   1625 C CD  . GLN B 2 161 ? -35.09601 11.26588 -10.79111 1.000 27.54633 ? 493 GLN B CD  1 
ATOM   1626 O OE1 . GLN B 2 161 ? -34.68709 12.25045 -11.38670 1.000 25.44735 ? 493 GLN B OE1 1 
ATOM   1627 N NE2 . GLN B 2 161 ? -36.07637 10.48776 -11.26738 1.000 28.64231 ? 493 GLN B NE2 1 
ATOM   1628 N N   . SER B 2 162 ? -38.45661 12.32923 -8.36887  1.000 24.13930 ? 494 SER B N   1 
ATOM   1629 C CA  . SER B 2 162 ? -39.83312 12.15129 -7.93120  1.000 23.93733 ? 494 SER B CA  1 
ATOM   1630 C C   . SER B 2 162 ? -40.18295 10.67961 -7.75054  1.000 24.36279 ? 494 SER B C   1 
ATOM   1631 O O   . SER B 2 162 ? -39.78740 9.82590  -8.54992  1.000 23.39996 ? 494 SER B O   1 
ATOM   1632 C CB  . SER B 2 162 ? -40.79458 12.76040 -8.93877  1.000 30.52342 ? 494 SER B CB  1 
ATOM   1633 O OG  . SER B 2 162 ? -42.11048 12.45778 -8.54560  1.000 32.97303 ? 494 SER B OG  1 
ATOM   1634 N N   . TYR B 2 163 ? -40.96708 10.38736 -6.70760  1.000 22.34502 ? 495 TYR B N   1 
ATOM   1635 C CA  . TYR B 2 163 ? -41.47674 9.02975  -6.55628  1.000 23.31886 ? 495 TYR B CA  1 
ATOM   1636 C C   . TYR B 2 163 ? -42.47816 8.68137  -7.65837  1.000 26.35246 ? 495 TYR B C   1 
ATOM   1637 O O   . TYR B 2 163 ? -42.54506 7.52471  -8.08642  1.000 27.53790 ? 495 TYR B O   1 
ATOM   1638 C CB  . TYR B 2 163 ? -42.11815 8.85196  -5.18069  1.000 20.28902 ? 495 TYR B CB  1 
ATOM   1639 C CG  . TYR B 2 163 ? -41.14988 8.48105  -4.07080  1.000 19.73961 ? 495 TYR B CG  1 
ATOM   1640 C CD1 . TYR B 2 163 ? -40.47503 7.26984  -4.08947  1.000 17.94868 ? 495 TYR B CD1 1 
ATOM   1641 C CD2 . TYR B 2 163 ? -40.94131 9.32896  -2.98794  1.000 18.44296 ? 495 TYR B CD2 1 
ATOM   1642 C CE1 . TYR B 2 163 ? -39.59229 6.92179  -3.06028  1.000 21.72207 ? 495 TYR B CE1 1 
ATOM   1643 C CE2 . TYR B 2 163 ? -40.07074 8.99109  -1.95555  1.000 16.89540 ? 495 TYR B CE2 1 
ATOM   1644 C CZ  . TYR B 2 163 ? -39.40581 7.79049  -1.99195  1.000 17.85582 ? 495 TYR B CZ  1 
ATOM   1645 O OH  . TYR B 2 163 ? -38.54434 7.43767  -0.97000  1.000 16.82034 ? 495 TYR B OH  1 
ATOM   1646 N N   . GLY B 2 164 ? -43.27227 9.65042  -8.10528  1.000 25.04342 ? 496 GLY B N   1 
ATOM   1647 C CA  . GLY B 2 164 ? -44.24360 9.40417  -9.16099  1.000 30.88193 ? 496 GLY B CA  1 
ATOM   1648 C C   . GLY B 2 164 ? -45.31445 8.39354  -8.80907  1.000 30.77998 ? 496 GLY B C   1 
ATOM   1649 O O   . GLY B 2 164 ? -45.78967 7.67636  -9.69425  1.000 35.56963 ? 496 GLY B O   1 
ATOM   1650 N N   . PHE B 2 165 ? -45.72004 8.32790  -7.53770  1.000 26.62562 ? 497 PHE B N   1 
ATOM   1651 C CA  . PHE B 2 165 ? -46.65654 7.30952  -7.07734  1.000 26.00066 ? 497 PHE B CA  1 
ATOM   1652 C C   . PHE B 2 165 ? -47.92770 7.26590  -7.91848  1.000 27.27969 ? 497 PHE B C   1 
ATOM   1653 O O   . PHE B 2 165 ? -48.62445 8.27177  -8.07403  1.000 26.90933 ? 497 PHE B O   1 
ATOM   1654 C CB  . PHE B 2 165 ? -47.03468 7.56713  -5.61642  1.000 24.01935 ? 497 PHE B CB  1 
ATOM   1655 C CG  . PHE B 2 165 ? -45.89270 7.42218  -4.65385  1.000 22.04510 ? 497 PHE B CG  1 
ATOM   1656 C CD1 . PHE B 2 165 ? -45.23313 6.21198  -4.51919  1.000 23.94399 ? 497 PHE B CD1 1 
ATOM   1657 C CD2 . PHE B 2 165 ? -45.51248 8.48636  -3.84584  1.000 23.22420 ? 497 PHE B CD2 1 
ATOM   1658 C CE1 . PHE B 2 165 ? -44.19534 6.05446  -3.59848  1.000 22.43615 ? 497 PHE B CE1 1 
ATOM   1659 C CE2 . PHE B 2 165 ? -44.48126 8.34540  -2.92645  1.000 21.47969 ? 497 PHE B CE2 1 
ATOM   1660 C CZ  . PHE B 2 165 ? -43.81465 7.12777  -2.80498  1.000 20.41405 ? 497 PHE B CZ  1 
ATOM   1661 N N   . GLN B 2 166 ? -48.24053 6.07266  -8.42399  1.000 31.59720 ? 498 GLN B N   1 
ATOM   1662 C CA  . GLN B 2 166 ? -49.48920 5.76464  -9.10142  1.000 32.67705 ? 498 GLN B CA  1 
ATOM   1663 C C   . GLN B 2 166 ? -50.23171 4.66049  -8.35810  1.000 29.26528 ? 498 GLN B C   1 
ATOM   1664 O O   . GLN B 2 166 ? -49.59855 3.71577  -7.87754  1.000 29.58155 ? 498 GLN B O   1 
ATOM   1665 C CB  . GLN B 2 166 ? -49.21666 5.32613  -10.54171 1.000 35.49438 ? 498 GLN B CB  1 
ATOM   1666 C CG  . GLN B 2 166 ? -48.41587 6.34308  -11.31139 1.000 38.68874 ? 498 GLN B CG  1 
ATOM   1667 C CD  . GLN B 2 166 ? -48.24547 5.96736  -12.76064 1.000 46.78278 ? 498 GLN B CD  1 
ATOM   1668 O OE1 . GLN B 2 166 ? -48.90734 6.52606  -13.63518 1.000 51.08740 ? 498 GLN B OE1 1 
ATOM   1669 N NE2 . GLN B 2 166 ? -47.35387 5.01696  -13.02873 1.000 48.43129 ? 498 GLN B NE2 1 
ATOM   1670 N N   . PRO B 2 167 ? -51.56227 4.73627  -8.25440  1.000 33.36893 ? 499 PRO B N   1 
ATOM   1671 C CA  . PRO B 2 167 ? -52.28656 3.75937  -7.41884  1.000 32.49710 ? 499 PRO B CA  1 
ATOM   1672 C C   . PRO B 2 167 ? -52.18110 2.33453  -7.92166  1.000 33.66994 ? 499 PRO B C   1 
ATOM   1673 O O   . PRO B 2 167 ? -52.45064 1.40288  -7.15447  1.000 32.74284 ? 499 PRO B O   1 
ATOM   1674 C CB  . PRO B 2 167 ? -53.73745 4.26619  -7.45529  1.000 32.07254 ? 499 PRO B CB  1 
ATOM   1675 C CG  . PRO B 2 167 ? -53.83275 5.06916  -8.70365  1.000 32.65752 ? 499 PRO B CG  1 
ATOM   1676 C CD  . PRO B 2 167 ? -52.47264 5.69802  -8.89675  1.000 35.59945 ? 499 PRO B CD  1 
ATOM   1677 N N   . THR B 2 168 ? -51.78320 2.13340  -9.17747  1.000 34.36808 ? 500 THR B N   1 
ATOM   1678 C CA  . THR B 2 168 ? -51.61605 0.80248  -9.74033  1.000 29.61978 ? 500 THR B CA  1 
ATOM   1679 C C   . THR B 2 168 ? -50.26889 0.17841  -9.40474  1.000 34.46086 ? 500 THR B C   1 
ATOM   1680 O O   . THR B 2 168 ? -50.04352 -0.98239 -9.76113  1.000 31.61522 ? 500 THR B O   1 
ATOM   1681 C CB  . THR B 2 168 ? -51.80386 0.85234  -11.26485 1.000 33.77313 ? 500 THR B CB  1 
ATOM   1682 O OG1 . THR B 2 168 ? -50.85051 1.75069  -11.84803 1.000 32.30278 ? 500 THR B OG1 1 
ATOM   1683 C CG2 . THR B 2 168 ? -53.22670 1.31982  -11.61894 1.000 31.42386 ? 500 THR B CG2 1 
ATOM   1684 N N   . ASN B 2 169 ? -49.37725 0.90261  -8.72159  1.000 30.72171 ? 501 ASN B N   1 
ATOM   1685 C CA  . ASN B 2 169 ? -48.10057 0.32655  -8.32093  1.000 27.44397 ? 501 ASN B CA  1 
ATOM   1686 C C   . ASN B 2 169 ? -48.31026 -0.91632 -7.46325  1.000 27.16442 ? 501 ASN B C   1 
ATOM   1687 O O   . ASN B 2 169 ? -49.30375 -1.04248 -6.74732  1.000 30.83949 ? 501 ASN B O   1 
ATOM   1688 C CB  . ASN B 2 169 ? -47.26573 1.34627  -7.53240  1.000 28.11615 ? 501 ASN B CB  1 
ATOM   1689 C CG  . ASN B 2 169 ? -46.67097 2.43520  -8.41496  1.000 35.57486 ? 501 ASN B CG  1 
ATOM   1690 O OD1 . ASN B 2 169 ? -46.74781 2.36739  -9.63931  1.000 33.24340 ? 501 ASN B OD1 1 
ATOM   1691 N ND2 . ASN B 2 169 ? -46.06073 3.44201  -7.79107  1.000 31.08980 ? 501 ASN B ND2 1 
ATOM   1692 N N   . GLY B 2 170 ? -47.36288 -1.84661 -7.55025  1.000 27.80263 ? 502 GLY B N   1 
ATOM   1693 C CA  . GLY B 2 170 ? -47.29412 -2.90881 -6.56644  1.000 28.91699 ? 502 GLY B CA  1 
ATOM   1694 C C   . GLY B 2 170 ? -47.06961 -2.34303 -5.17783  1.000 31.46392 ? 502 GLY B C   1 
ATOM   1695 O O   . GLY B 2 170 ? -46.53495 -1.24632 -5.01677  1.000 27.16477 ? 502 GLY B O   1 
ATOM   1696 N N   . VAL B 2 171 ? -47.49780 -3.09619 -4.16029  1.000 28.30546 ? 503 VAL B N   1 
ATOM   1697 C CA  . VAL B 2 171 ? -47.60314 -2.50302 -2.82872  1.000 28.16429 ? 503 VAL B CA  1 
ATOM   1698 C C   . VAL B 2 171 ? -46.23483 -2.07060 -2.30052  1.000 29.37965 ? 503 VAL B C   1 
ATOM   1699 O O   . VAL B 2 171 ? -46.13142 -1.09675 -1.54154  1.000 28.02580 ? 503 VAL B O   1 
ATOM   1700 C CB  . VAL B 2 171 ? -48.32194 -3.46955 -1.86345  1.000 32.28943 ? 503 VAL B CB  1 
ATOM   1701 C CG1 . VAL B 2 171 ? -47.52303 -4.76241 -1.68198  1.000 32.44213 ? 503 VAL B CG1 1 
ATOM   1702 C CG2 . VAL B 2 171 ? -48.57379 -2.78499 -0.53223  1.000 32.90628 ? 503 VAL B CG2 1 
ATOM   1703 N N   . GLY B 2 172 ? -45.16708 -2.75491 -2.70486  1.000 26.32726 ? 504 GLY B N   1 
ATOM   1704 C CA  . GLY B 2 172 ? -43.84317 -2.32943 -2.29436  1.000 26.56773 ? 504 GLY B CA  1 
ATOM   1705 C C   . GLY B 2 172 ? -43.44790 -0.98066 -2.85007  1.000 27.61694 ? 504 GLY B C   1 
ATOM   1706 O O   . GLY B 2 172 ? -42.58056 -0.31391 -2.27641  1.000 25.75450 ? 504 GLY B O   1 
ATOM   1707 N N   . TYR B 2 173 ? -44.06548 -0.56220 -3.95507  1.000 24.31643 ? 505 TYR B N   1 
ATOM   1708 C CA  . TYR B 2 173 ? -43.78504 0.71537  -4.59323  1.000 23.49590 ? 505 TYR B CA  1 
ATOM   1709 C C   . TYR B 2 173 ? -44.88125 1.73784  -4.32801  1.000 24.42311 ? 505 TYR B C   1 
ATOM   1710 O O   . TYR B 2 173 ? -44.88199 2.81125  -4.93797  1.000 25.42360 ? 505 TYR B O   1 
ATOM   1711 C CB  . TYR B 2 173 ? -43.58146 0.51479  -6.10705  1.000 22.80103 ? 505 TYR B CB  1 
ATOM   1712 C CG  . TYR B 2 173 ? -42.42344 -0.40173 -6.41939  1.000 29.51796 ? 505 TYR B CG  1 
ATOM   1713 C CD1 . TYR B 2 173 ? -41.13427 0.10134  -6.58591  1.000 28.74088 ? 505 TYR B CD1 1 
ATOM   1714 C CD2 . TYR B 2 173 ? -42.60711 -1.77485 -6.52133  1.000 32.70374 ? 505 TYR B CD2 1 
ATOM   1715 C CE1 . TYR B 2 173 ? -40.06608 -0.73899 -6.85805  1.000 28.26739 ? 505 TYR B CE1 1 
ATOM   1716 C CE2 . TYR B 2 173 ? -41.54930 -2.62047 -6.79069  1.000 31.67663 ? 505 TYR B CE2 1 
ATOM   1717 C CZ  . TYR B 2 173 ? -40.27742 -2.09741 -6.95544  1.000 32.15353 ? 505 TYR B CZ  1 
ATOM   1718 O OH  . TYR B 2 173 ? -39.22060 -2.93750 -7.22586  1.000 35.46396 ? 505 TYR B OH  1 
ATOM   1719 N N   . GLN B 2 174 ? -45.81733 1.43145  -3.41972  1.000 20.38359 ? 506 GLN B N   1 
ATOM   1720 C CA  . GLN B 2 174 ? -46.85795 2.36800  -3.04862  1.000 20.23619 ? 506 GLN B CA  1 
ATOM   1721 C C   . GLN B 2 174 ? -46.35684 3.28144  -1.94112  1.000 23.37777 ? 506 GLN B C   1 
ATOM   1722 O O   . GLN B 2 174 ? -45.44565 2.91199  -1.19557  1.000 21.20476 ? 506 GLN B O   1 
ATOM   1723 C CB  . GLN B 2 174 ? -48.09751 1.60597  -2.57771  1.000 25.30037 ? 506 GLN B CB  1 
ATOM   1724 C CG  . GLN B 2 174 ? -48.81607 0.89475  -3.71614  1.000 23.64451 ? 506 GLN B CG  1 
ATOM   1725 C CD  . GLN B 2 174 ? -50.05228 0.15589  -3.26869  1.000 32.86975 ? 506 GLN B CD  1 
ATOM   1726 O OE1 . GLN B 2 174 ? -50.43551 0.19054  -2.08831  1.000 27.43296 ? 506 GLN B OE1 1 
ATOM   1727 N NE2 . GLN B 2 174 ? -50.69857 -0.51931 -4.21733  1.000 29.49209 ? 506 GLN B NE2 1 
ATOM   1728 N N   . PRO B 2 175 ? -46.95051 4.46776  -1.79236  1.000 21.78829 ? 507 PRO B N   1 
ATOM   1729 C CA  . PRO B 2 175 ? -46.48106 5.40194  -0.76143  1.000 22.35547 ? 507 PRO B CA  1 
ATOM   1730 C C   . PRO B 2 175 ? -46.89343 4.95578  0.62799   1.000 22.71876 ? 507 PRO B C   1 
ATOM   1731 O O   . PRO B 2 175 ? -48.01568 4.48748  0.83845   1.000 21.47799 ? 507 PRO B O   1 
ATOM   1732 C CB  . PRO B 2 175 ? -47.18083 6.71099  -1.12753  1.000 20.10912 ? 507 PRO B CB  1 
ATOM   1733 C CG  . PRO B 2 175 ? -48.45988 6.26298  -1.72644  1.000 22.01421 ? 507 PRO B CG  1 
ATOM   1734 C CD  . PRO B 2 175 ? -48.12569 4.99905  -2.50380  1.000 23.79034 ? 507 PRO B CD  1 
ATOM   1735 N N   . TYR B 2 176 ? -45.98690 5.14610  1.58685   1.000 20.13402 ? 508 TYR B N   1 
ATOM   1736 C CA  . TYR B 2 176 ? -46.27043 4.89558  2.99213   1.000 17.95818 ? 508 TYR B CA  1 
ATOM   1737 C C   . TYR B 2 176 ? -45.95151 6.14964  3.78561   1.000 19.67203 ? 508 TYR B C   1 
ATOM   1738 O O   . TYR B 2 176 ? -44.88745 6.74710  3.59529   1.000 19.32702 ? 508 TYR B O   1 
ATOM   1739 C CB  . TYR B 2 176 ? -45.45812 3.71224  3.53865   1.000 19.30049 ? 508 TYR B CB  1 
ATOM   1740 C CG  . TYR B 2 176 ? -46.09459 2.38794  3.21058   1.000 22.19853 ? 508 TYR B CG  1 
ATOM   1741 C CD1 . TYR B 2 176 ? -46.24811 1.98600  1.88348   1.000 23.48977 ? 508 TYR B CD1 1 
ATOM   1742 C CD2 . TYR B 2 176 ? -46.57080 1.54789  4.21995   1.000 24.68364 ? 508 TYR B CD2 1 
ATOM   1743 C CE1 . TYR B 2 176 ? -46.84450 0.76555  1.56600   1.000 25.36007 ? 508 TYR B CE1 1 
ATOM   1744 C CE2 . TYR B 2 176 ? -47.18180 0.32596  3.90764   1.000 24.60569 ? 508 TYR B CE2 1 
ATOM   1745 C CZ  . TYR B 2 176 ? -47.31172 -0.05474 2.58316   1.000 26.13849 ? 508 TYR B CZ  1 
ATOM   1746 O OH  . TYR B 2 176 ? -47.90781 -1.26632 2.27022   1.000 26.08524 ? 508 TYR B OH  1 
ATOM   1747 N N   . ARG B 2 177 ? -46.87411 6.54620  4.65723   1.000 20.14305 ? 509 ARG B N   1 
ATOM   1748 C CA  . ARG B 2 177 ? -46.59127 7.60844  5.61017   1.000 20.84895 ? 509 ARG B CA  1 
ATOM   1749 C C   . ARG B 2 177 ? -45.89256 7.02116  6.82661   1.000 19.78166 ? 509 ARG B C   1 
ATOM   1750 O O   . ARG B 2 177 ? -46.26462 5.95235  7.32615   1.000 18.22420 ? 509 ARG B O   1 
ATOM   1751 C CB  . ARG B 2 177 ? -47.88453 8.33765  5.98943   1.000 21.03656 ? 509 ARG B CB  1 
ATOM   1752 C CG  . ARG B 2 177 ? -48.47043 9.08693  4.79915   1.000 21.78771 ? 509 ARG B CG  1 
ATOM   1753 C CD  . ARG B 2 177 ? -49.71285 9.91651  5.11289   1.000 21.56655 ? 509 ARG B CD  1 
ATOM   1754 N NE  . ARG B 2 177 ? -50.03359 10.79166 3.98757   1.000 23.63053 ? 509 ARG B NE  1 
ATOM   1755 C CZ  . ARG B 2 177 ? -50.81982 11.85630 4.05564   1.000 24.26661 ? 509 ARG B CZ  1 
ATOM   1756 N NH1 . ARG B 2 177 ? -51.39863 12.21710 5.19179   1.000 26.43558 ? 509 ARG B NH1 1 
ATOM   1757 N NH2 . ARG B 2 177 ? -51.02053 12.58565 2.95986   1.000 25.34103 ? 509 ARG B NH2 1 
ATOM   1758 N N   . VAL B 2 178 ? -44.84886 7.71437  7.28603   1.000 17.19772 ? 510 VAL B N   1 
ATOM   1759 C CA  . VAL B 2 178 ? -43.98947 7.24310  8.36121   1.000 15.61159 ? 510 VAL B CA  1 
ATOM   1760 C C   . VAL B 2 178 ? -43.93648 8.33417  9.41791   1.000 19.21288 ? 510 VAL B C   1 
ATOM   1761 O O   . VAL B 2 178 ? -43.84856 9.51880  9.08006   1.000 17.35320 ? 510 VAL B O   1 
ATOM   1762 C CB  . VAL B 2 178 ? -42.56689 6.90258  7.86093   1.000 17.09685 ? 510 VAL B CB  1 
ATOM   1763 C CG1 . VAL B 2 178 ? -41.68023 6.43434  9.01248   1.000 15.42101 ? 510 VAL B CG1 1 
ATOM   1764 C CG2 . VAL B 2 178 ? -42.61613 5.83463  6.75668   1.000 18.49510 ? 510 VAL B CG2 1 
ATOM   1765 N N   . VAL B 2 179 ? -44.06486 7.94061  10.68792  1.000 19.26098 ? 511 VAL B N   1 
ATOM   1766 C CA  . VAL B 2 179 ? -43.79593 8.81587  11.82742  1.000 19.50705 ? 511 VAL B CA  1 
ATOM   1767 C C   . VAL B 2 179 ? -42.75036 8.13805  12.69387  1.000 18.77690 ? 511 VAL B C   1 
ATOM   1768 O O   . VAL B 2 179 ? -42.89622 6.95926  13.04253  1.000 19.11299 ? 511 VAL B O   1 
ATOM   1769 C CB  . VAL B 2 179 ? -45.05691 9.11746  12.65519  1.000 19.22101 ? 511 VAL B CB  1 
ATOM   1770 C CG1 . VAL B 2 179 ? -44.66949 9.98372  13.88347  1.000 17.77006 ? 511 VAL B CG1 1 
ATOM   1771 C CG2 . VAL B 2 179 ? -46.08854 9.82647  11.80739  1.000 20.38504 ? 511 VAL B CG2 1 
ATOM   1772 N N   . VAL B 2 180 ? -41.68416 8.86561  13.01236  1.000 15.69338 ? 512 VAL B N   1 
ATOM   1773 C CA  . VAL B 2 180 ? -40.63620 8.38248  13.89884  1.000 16.51172 ? 512 VAL B CA  1 
ATOM   1774 C C   . VAL B 2 180 ? -40.73942 9.17814  15.19277  1.000 18.62396 ? 512 VAL B C   1 
ATOM   1775 O O   . VAL B 2 180 ? -40.62646 10.40960 15.17376  1.000 18.41221 ? 512 VAL B O   1 
ATOM   1776 C CB  . VAL B 2 180 ? -39.23962 8.54073  13.28288  1.000 16.90077 ? 512 VAL B CB  1 
ATOM   1777 C CG1 . VAL B 2 180 ? -38.17163 8.00032  14.24412  1.000 17.15132 ? 512 VAL B CG1 1 
ATOM   1778 C CG2 . VAL B 2 180 ? -39.14942 7.86163  11.89233  1.000 18.24799 ? 512 VAL B CG2 1 
ATOM   1779 N N   . LEU B 2 181 ? -40.93965 8.48926  16.31490  1.000 18.02984 ? 513 LEU B N   1 
ATOM   1780 C CA  . LEU B 2 181 ? -41.03239 9.14493  17.61754  1.000 20.34068 ? 513 LEU B CA  1 
ATOM   1781 C C   . LEU B 2 181 ? -39.71673 8.95600  18.35434  1.000 22.25783 ? 513 LEU B C   1 
ATOM   1782 O O   . LEU B 2 181 ? -39.27942 7.82145  18.56641  1.000 22.39710 ? 513 LEU B O   1 
ATOM   1783 C CB  . LEU B 2 181 ? -42.19405 8.58682  18.45253  1.000 20.49172 ? 513 LEU B CB  1 
ATOM   1784 C CG  . LEU B 2 181 ? -43.61021 8.74202  17.88994  1.000 20.55919 ? 513 LEU B CG  1 
ATOM   1785 C CD1 . LEU B 2 181 ? -44.64448 8.08970  18.82416  1.000 23.67931 ? 513 LEU B CD1 1 
ATOM   1786 C CD2 . LEU B 2 181 ? -43.98800 10.20502 17.60389  1.000 16.73585 ? 513 LEU B CD2 1 
ATOM   1787 N N   . SER B 2 182 ? -39.08563 10.06398 18.72995  1.000 18.54811 ? 514 SER B N   1 
ATOM   1788 C CA  . SER B 2 182 ? -37.86264 10.06324 19.51397  1.000 18.18070 ? 514 SER B CA  1 
ATOM   1789 C C   . SER B 2 182 ? -38.20696 10.54992 20.91457  1.000 21.08647 ? 514 SER B C   1 
ATOM   1790 O O   . SER B 2 182 ? -38.96795 11.50895 21.06663  1.000 20.43121 ? 514 SER B O   1 
ATOM   1791 C CB  . SER B 2 182 ? -36.80414 10.98878 18.89771  1.000 22.70923 ? 514 SER B CB  1 
ATOM   1792 O OG  . SER B 2 182 ? -36.29790 10.47747 17.69140  1.000 28.93197 ? 514 SER B OG  1 
ATOM   1793 N N   . PHE B 2 183 ? -37.66096 9.88841  21.93118  1.000 18.36079 ? 515 PHE B N   1 
ATOM   1794 C CA  . PHE B 2 183 ? -38.00040 10.17242 23.32650  1.000 24.49763 ? 515 PHE B CA  1 
ATOM   1795 C C   . PHE B 2 183 ? -36.77450 10.76919 23.99700  1.000 23.31129 ? 515 PHE B C   1 
ATOM   1796 O O   . PHE B 2 183 ? -35.78054 10.07301 24.22111  1.000 25.83294 ? 515 PHE B O   1 
ATOM   1797 C CB  . PHE B 2 183 ? -38.48241 8.91011  24.03757  1.000 24.52742 ? 515 PHE B CB  1 
ATOM   1798 C CG  . PHE B 2 183 ? -39.72317 8.34403  23.43084  1.000 22.96894 ? 515 PHE B CG  1 
ATOM   1799 C CD1 . PHE B 2 183 ? -40.95737 8.86883  23.74333  1.000 24.73411 ? 515 PHE B CD1 1 
ATOM   1800 C CD2 . PHE B 2 183 ? -39.64701 7.33558  22.48345  1.000 28.29237 ? 515 PHE B CD2 1 
ATOM   1801 C CE1 . PHE B 2 183 ? -42.09535 8.37504  23.15523  1.000 24.63620 ? 515 PHE B CE1 1 
ATOM   1802 C CE2 . PHE B 2 183 ? -40.78807 6.83718  21.89327  1.000 25.98414 ? 515 PHE B CE2 1 
ATOM   1803 C CZ  . PHE B 2 183 ? -42.01082 7.35594  22.23155  1.000 23.02799 ? 515 PHE B CZ  1 
ATOM   1804 N N   . GLU B 2 184 ? -36.83067 12.06451 24.27473  1.000 21.75297 ? 516 GLU B N   1 
ATOM   1805 C CA  . GLU B 2 184 ? -35.66121 12.81498 24.71022  1.000 21.49825 ? 516 GLU B CA  1 
ATOM   1806 C C   . GLU B 2 184 ? -35.64036 12.88003 26.22918  1.000 23.37376 ? 516 GLU B C   1 
ATOM   1807 O O   . GLU B 2 184 ? -36.61754 13.32031 26.84081  1.000 22.18115 ? 516 GLU B O   1 
ATOM   1808 C CB  . GLU B 2 184 ? -35.67887 14.23203 24.13709  1.000 23.02061 ? 516 GLU B CB  1 
ATOM   1809 C CG  . GLU B 2 184 ? -34.40707 14.99431 24.42165  1.000 25.64284 ? 516 GLU B CG  1 
ATOM   1810 C CD  . GLU B 2 184 ? -34.41245 16.37783 23.81722  1.000 28.23321 ? 516 GLU B CD  1 
ATOM   1811 O OE1 . GLU B 2 184 ? -35.42327 17.09156 23.98581  1.000 32.23795 ? 516 GLU B OE1 1 
ATOM   1812 O OE2 . GLU B 2 184 ? -33.41233 16.73760 23.16533  1.000 28.52800 ? 516 GLU B OE2 1 
ATOM   1813 N N   . LEU B 2 185 ? -34.52651 12.46686 26.82752  1.000 21.30623 ? 517 LEU B N   1 
ATOM   1814 C CA  . LEU B 2 185 ? -34.36424 12.47384 28.28366  1.000 26.61555 ? 517 LEU B CA  1 
ATOM   1815 C C   . LEU B 2 185 ? -33.14239 13.31959 28.66641  1.000 24.52734 ? 517 LEU B C   1 
ATOM   1816 O O   . LEU B 2 185 ? -32.02582 12.80712 28.76956  1.000 27.64340 ? 517 LEU B O   1 
ATOM   1817 C CB  . LEU B 2 185 ? -34.24595 11.02743 28.80261  1.000 26.55448 ? 517 LEU B CB  1 
ATOM   1818 C CG  . LEU B 2 185 ? -34.33340 10.83169 30.31751  1.000 38.12483 ? 517 LEU B CG  1 
ATOM   1819 C CD1 . LEU B 2 185 ? -35.69772 11.26128 30.82931  1.000 35.42858 ? 517 LEU B CD1 1 
ATOM   1820 C CD2 . LEU B 2 185 ? -34.04636 9.38220  30.68411  1.000 37.37642 ? 517 LEU B CD2 1 
ATOM   1821 N N   . LEU B 2 186 ? -33.35133 14.62190 28.86551  1.000 20.71336 ? 518 LEU B N   1 
ATOM   1822 C CA  . LEU B 2 186 ? -32.27763 15.50423 29.29941  1.000 21.40445 ? 518 LEU B CA  1 
ATOM   1823 C C   . LEU B 2 186 ? -32.21108 15.49344 30.82773  1.000 23.74248 ? 518 LEU B C   1 
ATOM   1824 O O   . LEU B 2 186 ? -33.04255 14.87592 31.49061  1.000 23.62032 ? 518 LEU B O   1 
ATOM   1825 C CB  . LEU B 2 186 ? -32.50424 16.92278 28.77134  1.000 23.49069 ? 518 LEU B CB  1 
ATOM   1826 C CG  . LEU B 2 186 ? -32.72508 17.04139 27.25780  1.000 24.01596 ? 518 LEU B CG  1 
ATOM   1827 C CD1 . LEU B 2 186 ? -32.77940 18.51572 26.80441  1.000 23.12623 ? 518 LEU B CD1 1 
ATOM   1828 C CD2 . LEU B 2 186 ? -31.65218 16.26095 26.49876  1.000 23.95056 ? 518 LEU B CD2 1 
ATOM   1829 N N   . HIS B 2 187 ? -31.20701 16.17441 31.39174  1.000 22.99653 ? 519 HIS B N   1 
ATOM   1830 C CA  . HIS B 2 187 ? -31.14626 16.38626 32.84773  1.000 24.00660 ? 519 HIS B CA  1 
ATOM   1831 C C   . HIS B 2 187 ? -32.04704 17.57731 33.14802  1.000 26.55547 ? 519 HIS B C   1 
ATOM   1832 O O   . HIS B 2 187 ? -31.61126 18.72789 33.22331  1.000 25.71459 ? 519 HIS B O   1 
ATOM   1833 C CB  . HIS B 2 187 ? -29.71971 16.64045 33.32634  1.000 23.85269 ? 519 HIS B CB  1 
ATOM   1834 C CG  . HIS B 2 187 ? -28.80438 15.45971 33.19536  1.000 23.21495 ? 519 HIS B CG  1 
ATOM   1835 N ND1 . HIS B 2 187 ? -29.15913 14.30268 32.53445  1.000 33.11156 ? 519 HIS B ND1 1 
ATOM   1836 C CD2 . HIS B 2 187 ? -27.53939 15.26321 33.63799  1.000 26.11282 ? 519 HIS B CD2 1 
ATOM   1837 C CE1 . HIS B 2 187 ? -28.15197 13.44657 32.57127  1.000 27.10863 ? 519 HIS B CE1 1 
ATOM   1838 N NE2 . HIS B 2 187 ? -27.15878 14.00232 33.24040  1.000 33.94951 ? 519 HIS B NE2 1 
ATOM   1839 N N   . ALA B 2 188 ? -33.34231 17.29946 33.26629  1.000 21.34095 ? 520 ALA B N   1 
ATOM   1840 C CA  . ALA B 2 188 ? -34.32645 18.36712 33.19384  1.000 22.38348 ? 520 ALA B CA  1 
ATOM   1841 C C   . ALA B 2 188 ? -35.64253 17.85261 33.73302  1.000 25.34671 ? 520 ALA B C   1 
ATOM   1842 O O   . ALA B 2 188 ? -35.89540 16.64463 33.68019  1.000 23.19822 ? 520 ALA B O   1 
ATOM   1843 C CB  . ALA B 2 188 ? -34.51250 18.84526 31.74441  1.000 24.95938 ? 520 ALA B CB  1 
ATOM   1844 N N   . PRO B 2 189 ? -36.50679 18.73508 34.22552  1.000 24.79590 ? 521 PRO B N   1 
ATOM   1845 C CA  . PRO B 2 189 ? -37.87087 18.32191 34.55655  1.000 29.78213 ? 521 PRO B CA  1 
ATOM   1846 C C   . PRO B 2 189 ? -38.58165 17.85005 33.30169  1.000 29.59273 ? 521 PRO B C   1 
ATOM   1847 O O   . PRO B 2 189 ? -38.45333 18.44697 32.22727  1.000 25.49890 ? 521 PRO B O   1 
ATOM   1848 C CB  . PRO B 2 189 ? -38.50578 19.59919 35.12051  1.000 28.12613 ? 521 PRO B CB  1 
ATOM   1849 C CG  . PRO B 2 189 ? -37.32990 20.42213 35.59494  1.000 26.55344 ? 521 PRO B CG  1 
ATOM   1850 C CD  . PRO B 2 189 ? -36.23917 20.12877 34.62005  1.000 26.58967 ? 521 PRO B CD  1 
ATOM   1851 N N   . ALA B 2 190 ? -39.31484 16.75524 33.44134  1.000 25.01738 ? 522 ALA B N   1 
ATOM   1852 C CA  . ALA B 2 190 ? -40.07475 16.23151 32.31875  1.000 26.64046 ? 522 ALA B CA  1 
ATOM   1853 C C   . ALA B 2 190 ? -41.18719 17.19736 31.92711  1.000 29.21407 ? 522 ALA B C   1 
ATOM   1854 O O   . ALA B 2 190 ? -41.68692 17.96799 32.75036  1.000 27.86901 ? 522 ALA B O   1 
ATOM   1855 C CB  . ALA B 2 190 ? -40.66251 14.87308 32.67794  1.000 27.43444 ? 522 ALA B CB  1 
ATOM   1856 N N   . THR B 2 191 ? -41.56121 17.17358 30.64145  1.000 26.14905 ? 523 THR B N   1 
ATOM   1857 C CA  . THR B 2 191 ? -42.72149 17.91915 30.17150  1.000 24.51581 ? 523 THR B CA  1 
ATOM   1858 C C   . THR B 2 191 ? -43.71760 17.06025 29.40392  1.000 24.23819 ? 523 THR B C   1 
ATOM   1859 O O   . THR B 2 191 ? -44.83508 17.52332 29.16307  1.000 26.37233 ? 523 THR B O   1 
ATOM   1860 C CB  . THR B 2 191 ? -42.31729 19.12568 29.28832  1.000 24.05316 ? 523 THR B CB  1 
ATOM   1861 O OG1 . THR B 2 191 ? -42.15093 18.74177 27.90685  1.000 26.43071 ? 523 THR B OG1 1 
ATOM   1862 C CG2 . THR B 2 191 ? -41.02467 19.77766 29.79075  1.000 27.82452 ? 523 THR B CG2 1 
ATOM   1863 N N   . VAL B 2 192 ? -43.36583 15.83153 29.03492  1.000 22.90234 ? 524 VAL B N   1 
ATOM   1864 C CA  . VAL B 2 192 ? -44.27265 14.93043 28.32945  1.000 24.33279 ? 524 VAL B CA  1 
ATOM   1865 C C   . VAL B 2 192 ? -44.31729 13.64198 29.13182  1.000 25.65228 ? 524 VAL B C   1 
ATOM   1866 O O   . VAL B 2 192 ? -43.33450 12.89210 29.15885  1.000 26.44691 ? 524 VAL B O   1 
ATOM   1867 C CB  . VAL B 2 192 ? -43.82729 14.65492 26.88631  1.000 23.36058 ? 524 VAL B CB  1 
ATOM   1868 C CG1 . VAL B 2 192 ? -44.85410 13.76552 26.18551  1.000 25.01507 ? 524 VAL B CG1 1 
ATOM   1869 C CG2 . VAL B 2 192 ? -43.65524 15.96169 26.12379  1.000 21.79482 ? 524 VAL B CG2 1 
ATOM   1870 N N   . CYS B 2 193 ? -45.44157 13.38360 29.78745  1.000 27.78871 ? 525 CYS B N   1 
ATOM   1871 C CA  . CYS B 2 193 ? -45.58018 12.21552 30.64662  1.000 31.00627 ? 525 CYS B CA  1 
ATOM   1872 C C   . CYS B 2 193 ? -46.60638 11.24650 30.08236  1.000 31.47738 ? 525 CYS B C   1 
ATOM   1873 O O   . CYS B 2 193 ? -47.62712 11.66269 29.53515  1.000 30.08132 ? 525 CYS B O   1 
ATOM   1874 C CB  . CYS B 2 193 ? -45.99489 12.62017 32.06251  1.000 36.55786 ? 525 CYS B CB  1 
ATOM   1875 S SG  . CYS B 2 193 ? -44.64003 13.19208 33.07816  1.000 39.84682 ? 525 CYS B SG  1 
ATOM   1876 N N   . GLY B 2 194 ? -46.33390 9.95289  30.23094  1.000 36.71797 ? 526 GLY B N   1 
ATOM   1877 C CA  . GLY B 2 194 ? -47.29734 8.94216  29.83488  1.000 40.70595 ? 526 GLY B CA  1 
ATOM   1878 C C   . GLY B 2 194 ? -48.57093 8.98882  30.66969  1.000 43.41195 ? 526 GLY B C   1 
ATOM   1879 O O   . GLY B 2 194 ? -48.63938 9.61444  31.72991  1.000 42.52548 ? 526 GLY B O   1 
ATOM   1880 N N   . SER B 2 195 ? -49.59785 8.28524  30.17171  1.000 40.96234 ? 527 SER B N   1 
ATOM   1881 C CA  . SER B 2 195 ? -50.92472 8.31106  30.79186  1.000 42.91537 ? 527 SER B CA  1 
ATOM   1882 C C   . SER B 2 195 ? -50.94514 7.65459  32.16898  1.000 42.22239 ? 527 SER B C   1 
ATOM   1883 O O   . SER B 2 195 ? -51.81595 7.96681  32.98804  1.000 44.71226 ? 527 SER B O   1 
ATOM   1884 C CB  . SER B 2 195 ? -51.94490 7.61922  29.87955  1.000 44.79816 ? 527 SER B CB  1 
ATOM   1885 O OG  . SER B 2 195 ? -52.58715 8.55199  29.02180  1.000 47.95268 ? 527 SER B OG  1 
ATOM   1886 N N   . ASN B 2 196 ? -50.02387 6.73817  32.44197  1.000 43.94360 ? 528 ASN B N   1 
ATOM   1887 C CA  . ASN B 2 196 ? -49.99382 6.02816  33.71429  1.000 44.25327 ? 528 ASN B CA  1 
ATOM   1888 C C   . ASN B 2 196 ? -48.71482 6.32456  34.48581  1.000 45.45831 ? 528 ASN B C   1 
ATOM   1889 O O   . ASN B 2 196 ? -48.26684 5.51291  35.29979  1.000 47.96100 ? 528 ASN B O   1 
ATOM   1890 C CB  . ASN B 2 196 ? -50.15477 4.52417  33.49398  1.000 49.84630 ? 528 ASN B CB  1 
ATOM   1891 C CG  . ASN B 2 196 ? -51.51232 4.16415  32.92542  1.000 51.68688 ? 528 ASN B CG  1 
ATOM   1892 O OD1 . ASN B 2 196 ? -51.61708 3.69394  31.79118  1.000 56.85013 ? 528 ASN B OD1 1 
ATOM   1893 N ND2 . ASN B 2 196 ? -52.56397 4.39125  33.70983  1.000 51.47270 ? 528 ASN B ND2 1 
ATOM   1894 N N   . SER B 2 197 ? -48.11510 7.48460  34.23531  1.000 42.60492 ? 529 SER B N   1 
ATOM   1895 C CA  . SER B 2 197 ? -46.91496 7.87100  34.95864  1.000 47.14558 ? 529 SER B CA  1 
ATOM   1896 C C   . SER B 2 197 ? -47.24783 8.16414  36.41758  1.000 47.63520 ? 529 SER B C   1 
ATOM   1897 O O   . SER B 2 197 ? -48.36322 8.57697  36.74780  1.000 47.17895 ? 529 SER B O   1 
ATOM   1898 C CB  . SER B 2 197 ? -46.27298 9.09684  34.31238  1.000 40.76810 ? 529 SER B CB  1 
ATOM   1899 O OG  . SER B 2 197 ? -47.21816 10.14709 34.20897  1.000 42.72044 ? 529 SER B OG  1 
ATOM   1900 N N   . GLU B 2 198 ? -46.25197 7.95152  37.28104  1.000 49.91699 ? 530 GLU B N   1 
ATOM   1901 C CA  . GLU B 2 198 ? -46.34536 8.11597  38.73747  1.000 54.91998 ? 530 GLU B CA  1 
ATOM   1902 C C   . GLU B 2 198 ? -47.17352 6.99772  39.36420  1.000 60.13310 ? 530 GLU B C   1 
ATOM   1903 O O   . GLU B 2 198 ? -46.62240 6.02799  39.89332  1.000 64.67014 ? 530 GLU B O   1 
ATOM   1904 C CB  . GLU B 2 198 ? -46.93195 9.48272  39.11104  1.000 58.00223 ? 530 GLU B CB  1 
ATOM   1905 C CG  . GLU B 2 198 ? -46.20718 10.66553 38.49314  1.000 57.17070 ? 530 GLU B CG  1 
ATOM   1906 C CD  . GLU B 2 198 ? -47.01887 11.94229 38.57873  1.000 64.28242 ? 530 GLU B CD  1 
ATOM   1907 O OE1 . GLU B 2 198 ? -48.13144 11.98321 38.00805  1.000 62.66670 ? 530 GLU B OE1 1 
ATOM   1908 O OE2 . GLU B 2 198 ? -46.55025 12.90086 39.22864  1.000 72.80655 ? 530 GLU B OE2 1 
HETATM 1909 C C1  . NAG C 3 .   ? -56.76297 10.61985 13.44282  1.000 38.15926 ? 1   NAG C C1  1 
HETATM 1910 C C2  . NAG C 3 .   ? -56.64869 10.46666 14.96339  1.000 39.40973 ? 1   NAG C C2  1 
HETATM 1911 C C3  . NAG C 3 .   ? -57.65217 9.43148  15.48578  1.000 44.35368 ? 1   NAG C C3  1 
HETATM 1912 C C4  . NAG C 3 .   ? -59.06277 9.71532  14.98271  1.000 46.16126 ? 1   NAG C C4  1 
HETATM 1913 C C5  . NAG C 3 .   ? -59.04149 9.82334  13.46512  1.000 47.40384 ? 1   NAG C C5  1 
HETATM 1914 C C6  . NAG C 3 .   ? -60.38505 10.18125 12.86940  1.000 51.74289 ? 1   NAG C C6  1 
HETATM 1915 C C7  . NAG C 3 .   ? -54.59478 10.67242 16.30746  1.000 34.53101 ? 1   NAG C C7  1 
HETATM 1916 C C8  . NAG C 3 .   ? -53.20947 10.14217 16.53239  1.000 35.85893 ? 1   NAG C C8  1 
HETATM 1917 N N2  . NAG C 3 .   ? -55.29389 10.08504 15.33107  1.000 35.78670 ? 1   NAG C N2  1 
HETATM 1918 O O3  . NAG C 3 .   ? -57.62468 9.44169  16.90771  1.000 42.15232 ? 1   NAG C O3  1 
HETATM 1919 O O4  . NAG C 3 .   ? -59.91810 8.62874  15.32427  1.000 53.01381 ? 1   NAG C O4  1 
HETATM 1920 O O5  . NAG C 3 .   ? -58.12690 10.85578 13.07898  1.000 44.31156 ? 1   NAG C O5  1 
HETATM 1921 O O6  . NAG C 3 .   ? -61.00888 11.24034 13.58288  1.000 53.62661 ? 1   NAG C O6  1 
HETATM 1922 O O7  . NAG C 3 .   ? -55.05517 11.58594 16.97818  1.000 35.47868 ? 1   NAG C O7  1 
HETATM 1923 C C1  . NAG C 3 .   ? -60.98847 8.97931  16.22106  1.000 54.79557 ? 2   NAG C C1  1 
HETATM 1924 C C2  . NAG C 3 .   ? -62.02846 7.87125  16.11304  1.000 58.61376 ? 2   NAG C C2  1 
HETATM 1925 C C3  . NAG C 3 .   ? -63.19274 8.14367  17.05714  1.000 59.15825 ? 2   NAG C C3  1 
HETATM 1926 C C4  . NAG C 3 .   ? -62.68215 8.34797  18.47673  1.000 59.88707 ? 2   NAG C C4  1 
HETATM 1927 C C5  . NAG C 3 .   ? -61.59354 9.41868  18.50576  1.000 57.58514 ? 2   NAG C C5  1 
HETATM 1928 C C6  . NAG C 3 .   ? -60.93398 9.54628  19.85938  1.000 60.27579 ? 2   NAG C C6  1 
HETATM 1929 C C7  . NAG C 3 .   ? -62.13087 6.70709  13.95948  1.000 57.79102 ? 2   NAG C C7  1 
HETATM 1930 C C8  . NAG C 3 .   ? -62.70591 6.70688  12.57538  1.000 55.33068 ? 2   NAG C C8  1 
HETATM 1931 N N2  . NAG C 3 .   ? -62.49877 7.72317  14.74606  1.000 58.01141 ? 2   NAG C N2  1 
HETATM 1932 O O3  . NAG C 3 .   ? -64.09368 7.04253  17.02035  1.000 63.04068 ? 2   NAG C O3  1 
HETATM 1933 O O4  . NAG C 3 .   ? -63.75392 8.74400  19.32583  1.000 69.53742 ? 2   NAG C O4  1 
HETATM 1934 O O5  . NAG C 3 .   ? -60.55124 9.09631  17.57117  1.000 57.60465 ? 2   NAG C O5  1 
HETATM 1935 O O6  . NAG C 3 .   ? -60.06548 8.45223  20.12320  1.000 56.54856 ? 2   NAG C O6  1 
HETATM 1936 O O7  . NAG C 3 .   ? -61.36924 5.82637  14.34926  1.000 51.05186 ? 2   NAG C O7  1 
HETATM 1937 C C1  . GOL D 4 .   ? -52.90521 7.47081  10.90061  1.000 33.27713 ? 601 GOL B C1  1 
HETATM 1938 O O1  . GOL D 4 .   ? -53.29301 8.31033  11.94122  1.000 36.98313 ? 601 GOL B O1  1 
HETATM 1939 C C2  . GOL D 4 .   ? -54.21941 6.98439  10.20360  1.000 38.30009 ? 601 GOL B C2  1 
HETATM 1940 O O2  . GOL D 4 .   ? -54.89761 8.00781  9.54863   1.000 46.31667 ? 601 GOL B O2  1 
HETATM 1941 C C3  . GOL D 4 .   ? -53.77448 5.86898  9.24942   1.000 33.30440 ? 601 GOL B C3  1 
HETATM 1942 O O3  . GOL D 4 .   ? -54.90912 5.44091  8.55215   1.000 41.20504 ? 601 GOL B O3  1 
HETATM 1943 C C1  . GOL E 4 .   ? -39.40648 -1.16623 9.55223   1.000 35.58647 ? 602 GOL B C1  1 
HETATM 1944 O O1  . GOL E 4 .   ? -39.66703 -2.53695 9.50788   1.000 41.50758 ? 602 GOL B O1  1 
HETATM 1945 C C2  . GOL E 4 .   ? -38.28154 -0.97742 10.56903  1.000 34.63213 ? 602 GOL B C2  1 
HETATM 1946 O O2  . GOL E 4 .   ? -37.76363 -2.20264 11.01530  1.000 39.53627 ? 602 GOL B O2  1 
HETATM 1947 C C3  . GOL E 4 .   ? -38.91839 -0.13594 11.71048  1.000 30.29350 ? 602 GOL B C3  1 
HETATM 1948 O O3  . GOL E 4 .   ? -37.86632 0.38663  12.41373  1.000 25.90794 ? 602 GOL B O3  1 
HETATM 1949 O O   . HOH F 5 .   ? -30.55246 7.55551  -23.67030 1.000 32.53834 ? 101 HOH A O   1 
HETATM 1950 O O   . HOH F 5 .   ? -16.30973 13.14833 -18.08788 1.000 38.38106 ? 102 HOH A O   1 
HETATM 1951 O O   . HOH F 5 .   ? -44.92637 -0.00000 -16.83333 0.50  39.68629 ? 103 HOH A O   1 
HETATM 1952 O O   . HOH F 5 .   ? -17.77878 5.73911  -20.29703 1.000 37.99605 ? 104 HOH A O   1 
HETATM 1953 O O   . HOH F 5 .   ? -15.47595 9.09365  -14.29141 1.000 37.40583 ? 105 HOH A O   1 
HETATM 1954 O O   . HOH F 5 .   ? -23.50431 -1.42070 -4.43471  1.000 34.88197 ? 106 HOH A O   1 
HETATM 1955 O O   . HOH F 5 .   ? -25.73140 0.26139  0.15229   1.000 39.43651 ? 107 HOH A O   1 
HETATM 1956 O O   . HOH F 5 .   ? -35.16724 16.81371 -12.48656 1.000 40.47208 ? 108 HOH A O   1 
HETATM 1957 O O   . HOH F 5 .   ? -16.88105 9.76899  -20.70069 1.000 36.72912 ? 109 HOH A O   1 
HETATM 1958 O O   . HOH F 5 .   ? -36.21166 -2.29739 -7.20589  1.000 36.77679 ? 110 HOH A O   1 
HETATM 1959 O O   . HOH F 5 .   ? -33.55680 -2.54113 -9.37014  1.000 27.86627 ? 111 HOH A O   1 
HETATM 1960 O O   . HOH F 5 .   ? -28.74482 14.18926 -18.37815 1.000 36.22350 ? 112 HOH A O   1 
HETATM 1961 O O   . HOH F 5 .   ? -37.85689 11.34969 -13.39566 1.000 39.38594 ? 113 HOH A O   1 
HETATM 1962 O O   . HOH F 5 .   ? -44.80822 1.83383  -14.10306 1.000 44.82435 ? 114 HOH A O   1 
HETATM 1963 O O   . HOH F 5 .   ? -30.94098 5.63513  -22.40873 1.000 27.61780 ? 115 HOH A O   1 
HETATM 1964 O O   . HOH F 5 .   ? -19.71925 3.14853  -19.71645 1.000 30.14968 ? 116 HOH A O   1 
HETATM 1965 O O   . HOH F 5 .   ? -47.40545 6.85582  -21.61014 1.000 52.16556 ? 117 HOH A O   1 
HETATM 1966 O O   . HOH F 5 .   ? -26.06080 11.74678 -23.54075 1.000 45.71374 ? 118 HOH A O   1 
HETATM 1967 O O   . HOH F 5 .   ? -19.225   -2.071   -11.385   1.000 37.10944 ? 119 HOH A O   1 
HETATM 1968 O O   . HOH F 5 .   ? -23.86905 7.74169  -27.35286 1.000 42.90829 ? 120 HOH A O   1 
HETATM 1969 O O   . HOH F 5 .   ? -19.30483 4.00742  -1.50545  1.000 49.22501 ? 121 HOH A O   1 
HETATM 1970 O O   . HOH F 5 .   ? -33.52771 9.20961  -23.58995 1.000 41.07865 ? 122 HOH A O   1 
HETATM 1971 O O   . HOH F 5 .   ? -32.85346 15.04630 -17.51800 1.000 38.67398 ? 123 HOH A O   1 
HETATM 1972 O O   . HOH F 5 .   ? -17.30874 7.20124  -13.87160 1.000 37.21690 ? 124 HOH A O   1 
HETATM 1973 O O   . HOH F 5 .   ? -24.57524 8.16119  -22.72957 1.000 33.05692 ? 125 HOH A O   1 
HETATM 1974 O O   . HOH F 5 .   ? -32.49739 13.18652 -19.26453 1.000 40.34523 ? 126 HOH A O   1 
HETATM 1975 O O   . HOH F 5 .   ? -35.26690 -0.55097 -2.29424  1.000 38.99441 ? 127 HOH A O   1 
HETATM 1976 O O   . HOH F 5 .   ? -33.70423 6.56286  -22.81603 1.000 36.59062 ? 128 HOH A O   1 
HETATM 1977 O O   . HOH F 5 .   ? -35.111   -4.999   -9.974    1.000 37.22606 ? 129 HOH A O   1 
HETATM 1978 O O   . HOH F 5 .   ? -18.35874 8.44612  -22.22681 1.000 39.40997 ? 130 HOH A O   1 
HETATM 1979 O O   . HOH F 5 .   ? -31.091   -3.618   -9.674    1.000 31.80122 ? 131 HOH A O   1 
HETATM 1980 O O   . HOH F 5 .   ? -32.66032 15.72622 -21.50164 1.000 51.86827 ? 132 HOH A O   1 
HETATM 1981 O O   . HOH G 5 .   ? -52.60326 9.10881  22.81330  1.000 34.90757 ? 701 HOH B O   1 
HETATM 1982 O O   . HOH G 5 .   ? -54.19234 7.67750  13.98208  1.000 34.66237 ? 702 HOH B O   1 
HETATM 1983 O O   . HOH G 5 .   ? -51.20811 6.17941  -13.47138 1.000 44.59760 ? 703 HOH B O   1 
HETATM 1984 O O   . HOH G 5 .   ? -47.84301 -2.33315 24.52964  1.000 49.24753 ? 704 HOH B O   1 
HETATM 1985 O O   . HOH G 5 .   ? -32.40325 18.71406 22.34120  1.000 38.97638 ? 705 HOH B O   1 
HETATM 1986 O O   . HOH G 5 .   ? -53.27528 9.81327  32.65491  1.000 48.74583 ? 706 HOH B O   1 
HETATM 1987 O O   . HOH G 5 .   ? -27.77819 3.32405  12.33708  1.000 28.31762 ? 707 HOH B O   1 
HETATM 1988 O O   . HOH G 5 .   ? -31.04700 0.81131  18.94279  1.000 38.73216 ? 708 HOH B O   1 
HETATM 1989 O O   . HOH G 5 .   ? -35.74183 5.88568  24.11507  1.000 37.05421 ? 709 HOH B O   1 
HETATM 1990 O O   . HOH G 5 .   ? -35.12921 23.59143 6.61032   1.000 39.06288 ? 710 HOH B O   1 
HETATM 1991 O O   . HOH G 5 .   ? -53.91122 -0.33690 15.65826  1.000 32.08208 ? 711 HOH B O   1 
HETATM 1992 O O   . HOH G 5 .   ? -49.57984 -5.38577 20.25150  1.000 39.21994 ? 712 HOH B O   1 
HETATM 1993 O O   . HOH G 5 .   ? -26.79813 18.31306 5.56411   1.000 35.77746 ? 713 HOH B O   1 
HETATM 1994 O O   . HOH G 5 .   ? -12.25160 14.50689 -12.21958 1.000 39.57457 ? 714 HOH B O   1 
HETATM 1995 O O   . HOH G 5 .   ? -22.60248 8.46359  -2.38959  1.000 29.34006 ? 715 HOH B O   1 
HETATM 1996 O O   . HOH G 5 .   ? -38.33504 -4.98052 11.95112  1.000 40.43835 ? 716 HOH B O   1 
HETATM 1997 O O   . HOH G 5 .   ? -20.30550 10.12851 -7.43536  1.000 38.11661 ? 717 HOH B O   1 
HETATM 1998 O O   . HOH G 5 .   ? -48.73291 1.60315  31.46966  1.000 42.79237 ? 718 HOH B O   1 
HETATM 1999 O O   . HOH G 5 .   ? -33.57235 6.76838  20.66454  1.000 33.13302 ? 719 HOH B O   1 
HETATM 2000 O O   . HOH G 5 .   ? -37.77213 11.43041 15.89925  1.000 20.60824 ? 720 HOH B O   1 
HETATM 2001 O O   . HOH G 5 .   ? -35.37131 20.82494 21.09357  1.000 38.81653 ? 721 HOH B O   1 
HETATM 2002 O O   . HOH G 5 .   ? -33.87194 21.91384 -14.93816 1.000 35.95142 ? 722 HOH B O   1 
HETATM 2003 O O   . HOH G 5 .   ? -54.14106 10.53194 28.82820  1.000 44.26899 ? 723 HOH B O   1 
HETATM 2004 O O   . HOH G 5 .   ? -32.39528 13.23932 -11.00460 1.000 27.05204 ? 724 HOH B O   1 
HETATM 2005 O O   . HOH G 5 .   ? -37.65131 8.33941  -9.46611  1.000 33.21076 ? 725 HOH B O   1 
HETATM 2006 O O   . HOH G 5 .   ? -31.64469 15.00921 22.59971  1.000 40.85879 ? 726 HOH B O   1 
HETATM 2007 O O   . HOH G 5 .   ? -33.68100 13.39166 33.45072  1.000 39.30554 ? 727 HOH B O   1 
HETATM 2008 O O   . HOH G 5 .   ? -44.50834 11.86122 -5.60669  1.000 26.62928 ? 728 HOH B O   1 
HETATM 2009 O O   . HOH G 5 .   ? -51.84831 18.68650 10.89133  1.000 40.19683 ? 729 HOH B O   1 
HETATM 2010 O O   . HOH G 5 .   ? -48.62153 15.68720 -8.88588  1.000 32.25106 ? 730 HOH B O   1 
HETATM 2011 O O   . HOH G 5 .   ? -23.21526 14.23631 6.19768   1.000 28.36467 ? 731 HOH B O   1 
HETATM 2012 O O   . HOH G 5 .   ? -24.08239 8.09544  9.16224   1.000 33.83023 ? 732 HOH B O   1 
HETATM 2013 O O   . HOH G 5 .   ? -53.52581 2.52821  5.51404   1.000 31.59517 ? 733 HOH B O   1 
HETATM 2014 O O   . HOH G 5 .   ? -32.74372 24.56983 -3.17316  1.000 30.18863 ? 734 HOH B O   1 
HETATM 2015 O O   . HOH G 5 .   ? -53.88645 5.83054  4.09765   1.000 37.95689 ? 735 HOH B O   1 
HETATM 2016 O O   . HOH G 5 .   ? -46.59901 2.50982  -12.91089 1.000 46.85269 ? 736 HOH B O   1 
HETATM 2017 O O   . HOH G 5 .   ? -36.65396 5.39916  -4.12853  1.000 23.07108 ? 737 HOH B O   1 
HETATM 2018 O O   . HOH G 5 .   ? -41.53293 15.74854 -8.68830  1.000 36.12155 ? 738 HOH B O   1 
HETATM 2019 O O   . HOH G 5 .   ? -20.12572 16.62765 -17.89944 1.000 32.94056 ? 739 HOH B O   1 
HETATM 2020 O O   . HOH G 5 .   ? -48.17857 19.34350 -7.49517  1.000 39.12147 ? 740 HOH B O   1 
HETATM 2021 O O   . HOH G 5 .   ? -46.97085 -3.99698 16.71576  1.000 28.73403 ? 741 HOH B O   1 
HETATM 2022 O O   . HOH G 5 .   ? -52.246   -3.401   10.647    1.000 30.31132 ? 742 HOH B O   1 
HETATM 2023 O O   . HOH G 5 .   ? -20.10989 8.81568  -9.66409  1.000 36.77298 ? 743 HOH B O   1 
HETATM 2024 O O   . HOH G 5 .   ? -30.20658 3.61378  9.93313   1.000 26.91582 ? 744 HOH B O   1 
HETATM 2025 O O   . HOH G 5 .   ? -54.16328 2.63635  7.91022   1.000 37.51610 ? 745 HOH B O   1 
HETATM 2026 O O   . HOH G 5 .   ? -27.00666 15.70859 -3.19374  1.000 18.68243 ? 746 HOH B O   1 
HETATM 2027 O O   . HOH G 5 .   ? -48.23988 1.34287  -11.79508 1.000 35.20044 ? 747 HOH B O   1 
HETATM 2028 O O   . HOH G 5 .   ? -34.46768 23.23198 -1.07429  1.000 25.94841 ? 748 HOH B O   1 
HETATM 2029 O O   . HOH G 5 .   ? -26.49400 4.86696  6.16635   1.000 26.13804 ? 749 HOH B O   1 
HETATM 2030 O O   . HOH G 5 .   ? -34.98312 7.97141  25.62595  1.000 34.75178 ? 750 HOH B O   1 
HETATM 2031 O O   . HOH G 5 .   ? -44.01752 10.10653 27.68296  1.000 41.86254 ? 751 HOH B O   1 
HETATM 2032 O O   . HOH G 5 .   ? -40.51705 -3.88765 -3.59279  1.000 34.65618 ? 752 HOH B O   1 
HETATM 2033 O O   . HOH G 5 .   ? -31.93090 17.32648 13.01989  1.000 37.13815 ? 753 HOH B O   1 
HETATM 2034 O O   . HOH G 5 .   ? -25.99818 17.17458 -0.99251  1.000 23.73505 ? 754 HOH B O   1 
HETATM 2035 O O   . HOH G 5 .   ? -23.82945 2.97537  2.63513   1.000 32.75913 ? 755 HOH B O   1 
HETATM 2036 O O   . HOH G 5 .   ? -29.31767 3.97890  23.16139  1.000 38.71284 ? 756 HOH B O   1 
HETATM 2037 O O   . HOH G 5 .   ? -52.39547 11.08249 7.64730   1.000 31.88911 ? 757 HOH B O   1 
HETATM 2038 O O   . HOH G 5 .   ? -50.77836 14.09481 -0.39224  1.000 29.83584 ? 758 HOH B O   1 
HETATM 2039 O O   . HOH G 5 .   ? -52.71091 -0.72946 -1.04954  1.000 31.37782 ? 759 HOH B O   1 
HETATM 2040 O O   . HOH G 5 .   ? -31.64662 14.39554 1.48990   1.000 19.19156 ? 760 HOH B O   1 
HETATM 2041 O O   . HOH G 5 .   ? -15.72719 18.25101 -7.86061  1.000 33.31316 ? 761 HOH B O   1 
HETATM 2042 O O   . HOH G 5 .   ? -32.46029 11.49859 25.43293  1.000 31.98761 ? 762 HOH B O   1 
HETATM 2043 O O   . HOH G 5 .   ? -45.59111 7.80066  -12.35854 1.000 40.75873 ? 763 HOH B O   1 
HETATM 2044 O O   . HOH G 5 .   ? -25.18348 5.68479  -4.50208  1.000 23.56709 ? 764 HOH B O   1 
HETATM 2045 O O   . HOH G 5 .   ? -35.25913 -2.87435 9.27061   1.000 30.22061 ? 765 HOH B O   1 
HETATM 2046 O O   . HOH G 5 .   ? -43.54906 15.63410 11.87741  1.000 19.19330 ? 766 HOH B O   1 
HETATM 2047 O O   . HOH G 5 .   ? -58.71769 6.02281  16.41744  1.000 44.20518 ? 767 HOH B O   1 
HETATM 2048 O O   . HOH G 5 .   ? -30.53868 16.10648 -14.05788 1.000 23.04350 ? 768 HOH B O   1 
HETATM 2049 O O   . HOH G 5 .   ? -32.40812 -2.17696 13.38804  1.000 34.84098 ? 769 HOH B O   1 
HETATM 2050 O O   . HOH G 5 .   ? -32.82901 14.36540 17.21518  1.000 38.83606 ? 770 HOH B O   1 
HETATM 2051 O O   . HOH G 5 .   ? -37.02743 15.19300 31.59117  1.000 28.10911 ? 771 HOH B O   1 
HETATM 2052 O O   . HOH G 5 .   ? -19.23582 19.77801 -9.96989  1.000 24.76869 ? 772 HOH B O   1 
HETATM 2053 O O   . HOH G 5 .   ? -47.31684 16.80897 7.73194   1.000 25.44353 ? 773 HOH B O   1 
HETATM 2054 O O   . HOH G 5 .   ? -25.83801 17.48731 -4.95173  1.000 23.41959 ? 774 HOH B O   1 
HETATM 2055 O O   . HOH G 5 .   ? -32.40908 14.92222 4.26499   1.000 18.38304 ? 775 HOH B O   1 
HETATM 2056 O O   . HOH G 5 .   ? -44.77044 -0.79288 6.77493   1.000 29.06639 ? 776 HOH B O   1 
HETATM 2057 O O   . HOH G 5 .   ? -25.03975 -0.07795 9.35010   1.000 44.48031 ? 777 HOH B O   1 
HETATM 2058 O O   . HOH G 5 .   ? -41.24933 7.17327  -10.44968 1.000 36.23987 ? 778 HOH B O   1 
HETATM 2059 O O   . HOH G 5 .   ? -36.91773 22.17668 -2.03197  1.000 28.22511 ? 779 HOH B O   1 
HETATM 2060 O O   . HOH G 5 .   ? -19.50116 15.00091 -14.13802 1.000 22.62015 ? 780 HOH B O   1 
HETATM 2061 O O   . HOH G 5 .   ? -40.32949 20.06650 5.27108   1.000 42.23004 ? 781 HOH B O   1 
HETATM 2062 O O   . HOH G 5 .   ? -21.77160 14.92858 1.18207   1.000 33.07052 ? 782 HOH B O   1 
HETATM 2063 O O   . HOH G 5 .   ? -52.46230 12.12752 -4.24666  1.000 40.16816 ? 783 HOH B O   1 
HETATM 2064 O O   . HOH G 5 .   ? -35.28806 -1.00028 0.95998   1.000 28.38318 ? 784 HOH B O   1 
HETATM 2065 O O   . HOH G 5 .   ? -57.15457 4.48475  19.88651  1.000 39.02778 ? 785 HOH B O   1 
HETATM 2066 O O   . HOH G 5 .   ? -19.71976 8.35619  -13.62256 1.000 31.96114 ? 786 HOH B O   1 
HETATM 2067 O O   . HOH G 5 .   ? -47.19419 14.99147 9.87963   1.000 22.84560 ? 787 HOH B O   1 
HETATM 2068 O O   . HOH G 5 .   ? -19.51042 14.30740 -6.56065  1.000 30.59137 ? 788 HOH B O   1 
HETATM 2069 O O   . HOH G 5 .   ? -51.05166 0.12572  6.14807   1.000 27.26485 ? 789 HOH B O   1 
HETATM 2070 O O   . HOH G 5 .   ? -29.716   23.666   -8.781    1.000 37.29015 ? 790 HOH B O   1 
HETATM 2071 O O   . HOH G 5 .   ? -27.65305 19.10334 -3.33823  1.000 26.39322 ? 791 HOH B O   1 
HETATM 2072 O O   . HOH G 5 .   ? -55.79898 10.07317 -9.38507  1.000 39.13899 ? 792 HOH B O   1 
HETATM 2073 O O   . HOH G 5 .   ? -44.25737 22.49550 18.33923  1.000 40.04209 ? 793 HOH B O   1 
HETATM 2074 O O   . HOH G 5 .   ? -39.54884 21.56917 26.52107  1.000 27.32682 ? 794 HOH B O   1 
HETATM 2075 O O   . HOH G 5 .   ? -26.51649 7.57542  6.41617   1.000 19.16353 ? 795 HOH B O   1 
HETATM 2076 O O   . HOH G 5 .   ? -26.37877 7.54193  -6.24118  1.000 22.24166 ? 796 HOH B O   1 
HETATM 2077 O O   . HOH G 5 .   ? -34.88742 2.34020  -2.67745  1.000 26.06944 ? 797 HOH B O   1 
HETATM 2078 O O   . HOH G 5 .   ? -10.88633 14.76904 -16.07444 1.000 36.28549 ? 798 HOH B O   1 
HETATM 2079 O O   . HOH G 5 .   ? -36.78833 21.14677 -8.15837  1.000 24.34380 ? 799 HOH B O   1 
HETATM 2080 O O   . HOH G 5 .   ? -27.25017 15.30776 12.59663  1.000 33.18347 ? 800 HOH B O   1 
HETATM 2081 O O   . HOH G 5 .   ? -31.90935 12.07090 9.24027   1.000 20.71051 ? 801 HOH B O   1 
HETATM 2082 O O   . HOH G 5 .   ? -44.78236 15.66755 7.40032   1.000 20.65352 ? 802 HOH B O   1 
HETATM 2083 O O   . HOH G 5 .   ? -41.36666 23.30318 26.51972  1.000 28.48908 ? 803 HOH B O   1 
HETATM 2084 O O   . HOH G 5 .   ? -45.68951 20.81115 31.21952  1.000 37.88312 ? 804 HOH B O   1 
HETATM 2085 O O   . HOH G 5 .   ? -49.17111 -2.74273 4.26013   1.000 34.66167 ? 805 HOH B O   1 
HETATM 2086 O O   . HOH G 5 .   ? -21.32541 19.41065 -8.10689  1.000 28.99241 ? 806 HOH B O   1 
HETATM 2087 O O   . HOH G 5 .   ? -41.92538 17.84422 35.52156  1.000 36.51773 ? 807 HOH B O   1 
HETATM 2088 O O   . HOH G 5 .   ? -35.92292 15.33330 -10.70501 1.000 28.12535 ? 808 HOH B O   1 
HETATM 2089 O O   . HOH G 5 .   ? -50.02758 14.59394 -2.88168  1.000 34.69524 ? 809 HOH B O   1 
HETATM 2090 O O   . HOH G 5 .   ? -36.54575 21.93164 -4.94821  1.000 23.41603 ? 810 HOH B O   1 
HETATM 2091 O O   . HOH G 5 .   ? -42.13908 21.83752 16.61569  1.000 30.22472 ? 811 HOH B O   1 
HETATM 2092 O O   . HOH G 5 .   ? -54.25603 15.16065 18.68666  1.000 33.16096 ? 812 HOH B O   1 
HETATM 2093 O O   . HOH G 5 .   ? -32.67726 5.50359  8.71379   1.000 20.37675 ? 813 HOH B O   1 
HETATM 2094 O O   . HOH G 5 .   ? -51.58114 -2.64170 -7.02459  1.000 43.98226 ? 814 HOH B O   1 
HETATM 2095 O O   . HOH G 5 .   ? -54.97634 1.46366  -2.40410  1.000 41.66971 ? 815 HOH B O   1 
HETATM 2096 O O   . HOH G 5 .   ? -40.90666 11.80791 -0.09231  1.000 18.69093 ? 816 HOH B O   1 
HETATM 2097 O O   . HOH G 5 .   ? -30.05798 7.95354  20.15520  1.000 46.29134 ? 817 HOH B O   1 
HETATM 2098 O O   . HOH G 5 .   ? -38.26117 8.31872  31.48328  1.000 43.17905 ? 818 HOH B O   1 
HETATM 2099 O O   . HOH G 5 .   ? -39.09624 15.37640 35.87930  1.000 33.48710 ? 819 HOH B O   1 
HETATM 2100 O O   . HOH G 5 .   ? -43.93186 20.64427 12.30685  1.000 38.36449 ? 820 HOH B O   1 
HETATM 2101 O O   . HOH G 5 .   ? -28.89945 24.11954 -2.88375  1.000 29.50619 ? 821 HOH B O   1 
HETATM 2102 O O   . HOH G 5 .   ? -38.11693 13.13908 -11.04868 1.000 25.48178 ? 822 HOH B O   1 
HETATM 2103 O O   . HOH G 5 .   ? -44.80137 -5.19308 10.40808  1.000 29.13643 ? 823 HOH B O   1 
HETATM 2104 O O   . HOH G 5 .   ? -22.92885 17.94714 -20.45451 1.000 31.80452 ? 824 HOH B O   1 
HETATM 2105 O O   . HOH G 5 .   ? -20.14884 19.32730 -17.06672 1.000 31.96277 ? 825 HOH B O   1 
HETATM 2106 O O   . HOH G 5 .   ? -52.48659 -1.51696 13.65909  1.000 27.58948 ? 826 HOH B O   1 
HETATM 2107 O O   . HOH G 5 .   ? -49.31441 18.92447 30.88006  1.000 43.71979 ? 827 HOH B O   1 
HETATM 2108 O O   . HOH G 5 .   ? -25.24785 2.32902  9.38109   1.000 36.54278 ? 828 HOH B O   1 
HETATM 2109 O O   . HOH G 5 .   ? -44.27314 5.19731  -9.17541  1.000 35.30808 ? 829 HOH B O   1 
HETATM 2110 O O   . HOH G 5 .   ? -25.11267 5.93932  14.92195  1.000 34.62448 ? 830 HOH B O   1 
HETATM 2111 O O   . HOH G 5 .   ? -39.74948 -2.16717 3.97862   1.000 22.03563 ? 831 HOH B O   1 
HETATM 2112 O O   . HOH G 5 .   ? -39.33466 2.53188  22.54311  1.000 35.86582 ? 832 HOH B O   1 
HETATM 2113 O O   . HOH G 5 .   ? -42.47517 -3.68357 9.95374   1.000 39.15211 ? 833 HOH B O   1 
HETATM 2114 O O   . HOH G 5 .   ? -44.20600 -4.74308 -4.54078  1.000 34.66480 ? 834 HOH B O   1 
HETATM 2115 O O   . HOH G 5 .   ? -50.41142 -1.37714 24.06256  1.000 45.02123 ? 835 HOH B O   1 
HETATM 2116 O O   . HOH G 5 .   ? -20.30050 8.42437  3.70849   1.000 32.72754 ? 836 HOH B O   1 
HETATM 2117 O O   . HOH G 5 .   ? -54.29574 3.41731  1.17726   1.000 37.62638 ? 837 HOH B O   1 
HETATM 2118 O O   . HOH G 5 .   ? -40.86180 17.31274 -3.21473  1.000 22.88695 ? 838 HOH B O   1 
HETATM 2119 O O   . HOH G 5 .   ? -36.07158 7.50353  21.57026  1.000 28.57196 ? 839 HOH B O   1 
HETATM 2120 O O   . HOH G 5 .   ? -32.34008 1.70853  -1.47574  1.000 25.10274 ? 840 HOH B O   1 
HETATM 2121 O O   . HOH G 5 .   ? -53.21330 -2.51481 22.60557  1.000 45.90286 ? 841 HOH B O   1 
HETATM 2122 O O   . HOH G 5 .   ? -56.79255 14.29363 14.27790  1.000 38.77774 ? 842 HOH B O   1 
HETATM 2123 O O   . HOH G 5 .   ? -23.58783 15.74274 -2.08931  1.000 29.97378 ? 843 HOH B O   1 
HETATM 2124 O O   . HOH G 5 .   ? -37.35195 17.30188 -9.31617  1.000 32.28505 ? 844 HOH B O   1 
HETATM 2125 O O   . HOH G 5 .   ? -21.127   23.053   -17.107   1.000 31.03623 ? 845 HOH B O   1 
HETATM 2126 O O   . HOH G 5 .   ? -22.01298 7.91961  0.09578   1.000 35.79738 ? 846 HOH B O   1 
HETATM 2127 O O   . HOH G 5 .   ? -50.93009 19.15083 5.88577   1.000 34.15313 ? 847 HOH B O   1 
HETATM 2128 O O   . HOH G 5 .   ? -29.32245 18.73175 9.64669   1.000 28.19271 ? 848 HOH B O   1 
HETATM 2129 O O   . HOH G 5 .   ? -43.78819 -1.54721 4.55684   1.000 31.79428 ? 849 HOH B O   1 
HETATM 2130 O O   . HOH G 5 .   ? -22.80831 20.61266 -17.07793 1.000 32.79349 ? 850 HOH B O   1 
HETATM 2131 O O   . HOH G 5 .   ? -53.84667 17.05885 17.38343  1.000 41.45887 ? 851 HOH B O   1 
HETATM 2132 O O   . HOH G 5 .   ? -21.33602 16.93314 -6.57096  1.000 25.29846 ? 852 HOH B O   1 
HETATM 2133 O O   . HOH G 5 .   ? -29.00423 -2.49282 5.52181   1.000 32.90995 ? 853 HOH B O   1 
HETATM 2134 O O   . HOH G 5 .   ? -34.55793 18.97024 17.18030  1.000 32.40079 ? 854 HOH B O   1 
HETATM 2135 O O   . HOH G 5 .   ? -54.58112 3.79534  28.14201  1.000 50.35746 ? 855 HOH B O   1 
HETATM 2136 O O   . HOH G 5 .   ? -22.67520 21.96470 -9.76665  1.000 32.37150 ? 856 HOH B O   1 
HETATM 2137 O O   . HOH G 5 .   ? -24.93568 19.66884 -1.36072  1.000 36.18998 ? 857 HOH B O   1 
HETATM 2138 O O   . HOH G 5 .   ? -48.19104 -5.86234 -5.14695  1.000 38.50482 ? 858 HOH B O   1 
HETATM 2139 O O   . HOH G 5 .   ? -24.34085 9.43660  -5.01856  1.000 24.84150 ? 859 HOH B O   1 
HETATM 2140 O O   . HOH G 5 .   ? -41.01315 18.36023 2.47394   1.000 26.23115 ? 860 HOH B O   1 
HETATM 2141 O O   . HOH G 5 .   ? -33.37730 9.87796  22.37868  1.000 42.42472 ? 861 HOH B O   1 
HETATM 2142 O O   . HOH G 5 .   ? -49.00488 21.43032 18.80646  1.000 42.67121 ? 862 HOH B O   1 
HETATM 2143 O O   . HOH G 5 .   ? -37.93388 -3.69492 18.17402  1.000 44.58684 ? 863 HOH B O   1 
HETATM 2144 O O   . HOH G 5 .   ? -17.28822 12.39265 -9.45392  1.000 37.11211 ? 864 HOH B O   1 
HETATM 2145 O O   . HOH G 5 .   ? -42.10803 -3.11742 19.01199  1.000 33.20549 ? 865 HOH B O   1 
HETATM 2146 O O   . HOH G 5 .   ? -25.64958 23.61371 -8.63905  1.000 21.78913 ? 866 HOH B O   1 
HETATM 2147 O O   . HOH G 5 .   ? -53.06501 19.09068 8.16927   1.000 39.18330 ? 867 HOH B O   1 
HETATM 2148 O O   . HOH G 5 .   ? -44.23090 -2.39469 19.42026  1.000 40.44432 ? 868 HOH B O   1 
HETATM 2149 O O   . HOH G 5 .   ? -29.32276 21.49758 3.47111   1.000 27.50382 ? 869 HOH B O   1 
HETATM 2150 O O   . HOH G 5 .   ? -51.12574 11.28647 38.00786  1.000 50.91904 ? 870 HOH B O   1 
HETATM 2151 O O   . HOH G 5 .   ? -57.52827 11.70044 8.99928   1.000 51.16974 ? 871 HOH B O   1 
HETATM 2152 O O   . HOH G 5 .   ? -50.88730 19.07004 -5.30295  1.000 47.90736 ? 872 HOH B O   1 
HETATM 2153 O O   . HOH G 5 .   ? -46.87610 19.74850 22.14372  1.000 30.32336 ? 873 HOH B O   1 
HETATM 2154 O O   . HOH G 5 .   ? -29.68122 22.97279 -15.33747 1.000 38.35704 ? 874 HOH B O   1 
HETATM 2155 O O   . HOH G 5 .   ? -39.69439 20.74799 10.33796  1.000 39.66024 ? 875 HOH B O   1 
HETATM 2156 O O   . HOH G 5 .   ? -32.42375 21.35632 7.44115   1.000 33.81914 ? 876 HOH B O   1 
HETATM 2157 O O   . HOH G 5 .   ? -22.26998 20.60650 -4.16976  1.000 44.42191 ? 877 HOH B O   1 
HETATM 2158 O O   . HOH G 5 .   ? -18.26153 14.42916 -16.38085 1.000 27.47266 ? 878 HOH B O   1 
HETATM 2159 O O   . HOH G 5 .   ? -28.94010 15.72133 -16.40989 1.000 29.80470 ? 879 HOH B O   1 
HETATM 2160 O O   . HOH G 5 .   ? -40.87461 -3.10365 21.95453  1.000 42.22117 ? 880 HOH B O   1 
HETATM 2161 O O   . HOH G 5 .   ? -33.60965 9.34953  18.95327  1.000 33.84493 ? 881 HOH B O   1 
HETATM 2162 O O   . HOH G 5 .   ? -22.86821 6.01040  7.10440   1.000 35.58340 ? 882 HOH B O   1 
HETATM 2163 O O   . HOH G 5 .   ? -33.47825 -2.72945 20.26553  1.000 46.01037 ? 883 HOH B O   1 
HETATM 2164 O O   . HOH G 5 .   ? -55.79089 17.62544 9.86845   1.000 49.94123 ? 884 HOH B O   1 
HETATM 2165 O O   . HOH G 5 .   ? -38.03417 13.06744 32.62923  1.000 37.25845 ? 885 HOH B O   1 
HETATM 2166 O O   . HOH G 5 .   ? -32.56618 -1.10191 -1.26969  1.000 45.12548 ? 886 HOH B O   1 
HETATM 2167 O O   . HOH G 5 .   ? -27.63659 -0.59628 15.05608  1.000 44.09546 ? 887 HOH B O   1 
HETATM 2168 O O   . HOH G 5 .   ? -39.79311 8.09439  33.78977  1.000 34.58439 ? 888 HOH B O   1 
HETATM 2169 O O   . HOH G 5 .   ? -34.44715 -5.03308 15.89315  1.000 48.36674 ? 889 HOH B O   1 
HETATM 2170 O O   . HOH G 5 .   ? -33.96284 -3.67525 11.54071  1.000 41.17966 ? 890 HOH B O   1 
HETATM 2171 O O   . HOH G 5 .   ? -41.741   21.071   33.886    1.000 40.21461 ? 891 HOH B O   1 
HETATM 2172 O O   . HOH G 5 .   ? -38.93051 -4.29417 2.43200   1.000 40.29050 ? 892 HOH B O   1 
HETATM 2173 O O   . HOH G 5 .   ? -29.087   25.229   -5.903    1.000 38.89970 ? 893 HOH B O   1 
HETATM 2174 O O   . HOH G 5 .   ? -46.19057 17.06919 11.66934  1.000 37.43771 ? 894 HOH B O   1 
HETATM 2175 O O   . HOH G 5 .   ? -26.12723 24.57559 -1.70413  1.000 41.97754 ? 895 HOH B O   1 
HETATM 2176 O O   . HOH G 5 .   ? -52.00539 11.88366 23.52219  1.000 41.20544 ? 896 HOH B O   1 
HETATM 2177 O O   . HOH G 5 .   ? -54.66827 10.26610 7.03776   1.000 45.22741 ? 897 HOH B O   1 
HETATM 2178 O O   . HOH G 5 .   ? -46.92909 16.59192 31.69342  1.000 43.18445 ? 898 HOH B O   1 
HETATM 2179 O O   . HOH G 5 .   ? -31.48987 7.34783  22.54970  1.000 43.87381 ? 899 HOH B O   1 
HETATM 2180 O O   . HOH G 5 .   ? -45.67453 19.20301 2.86299   1.000 41.93079 ? 900 HOH B O   1 
HETATM 2181 O O   . HOH G 5 .   ? -57.91399 0.85460  14.49106  1.000 45.12862 ? 901 HOH B O   1 
HETATM 2182 O O   . HOH G 5 .   ? -34.57526 19.25143 -12.58851 1.000 36.35876 ? 902 HOH B O   1 
HETATM 2183 O O   . HOH G 5 .   ? -33.68300 12.48355 18.72832  1.000 42.09753 ? 903 HOH B O   1 
HETATM 2184 O O   . HOH G 5 .   ? -22.73050 2.48971  4.82053   1.000 39.28028 ? 904 HOH B O   1 
HETATM 2185 O O   . HOH G 5 .   ? -41.31077 -2.97908 6.42721   1.000 36.55662 ? 905 HOH B O   1 
HETATM 2186 O O   . HOH G 5 .   ? -49.24273 20.42223 23.54139  1.000 42.37415 ? 906 HOH B O   1 
HETATM 2187 O O   . HOH G 5 .   ? -47.11037 18.92928 31.51982  1.000 42.74861 ? 907 HOH B O   1 
HETATM 2188 O O   . HOH G 5 .   ? -31.56794 18.84561 11.39598  1.000 44.41487 ? 908 HOH B O   1 
HETATM 2189 O O   . HOH G 5 .   ? -14.86024 10.52816 -11.81752 1.000 45.39879 ? 909 HOH B O   1 
HETATM 2190 O O   . HOH G 5 .   ? -53.61779 11.81962 19.48846  1.000 39.69265 ? 910 HOH B O   1 
HETATM 2191 O O   . HOH G 5 .   ? -24.17283 -0.63902 12.14894  1.000 49.91029 ? 911 HOH B O   1 
HETATM 2192 O O   . HOH G 5 .   ? -51.99767 6.46676  -16.17742 1.000 44.49079 ? 912 HOH B O   1 
HETATM 2193 O O   . HOH G 5 .   ? -31.291   11.331   33.093    1.000 46.52855 ? 913 HOH B O   1 
HETATM 2194 O O   . HOH G 5 .   ? -37.16300 24.17267 5.24075   1.000 38.61312 ? 914 HOH B O   1 
HETATM 2195 O O   . HOH G 5 .   ? -24.53060 5.82491  12.02772  1.000 39.97986 ? 915 HOH B O   1 
HETATM 2196 O O   . HOH G 5 .   ? -43.36553 22.19402 13.86660  1.000 42.48539 ? 916 HOH B O   1 
HETATM 2197 O O   . HOH G 5 .   ? -24.10745 3.96730  7.00933   1.000 39.35758 ? 917 HOH B O   1 
HETATM 2198 O O   . HOH G 5 .   ? -23.61718 20.85818 -19.62707 1.000 41.34656 ? 918 HOH B O   1 
HETATM 2199 O O   . HOH G 5 .   ? -21.350   25.758   -17.580   1.000 38.91086 ? 919 HOH B O   1 
HETATM 2200 O O   . HOH G 5 .   ? -36.54962 21.73512 18.91925  1.000 39.78023 ? 920 HOH B O   1 
HETATM 2201 O O   . HOH G 5 .   ? -54.63623 18.03837 12.32240  1.000 45.49169 ? 921 HOH B O   1 
HETATM 2202 O O   . HOH G 5 .   ? -55.69795 12.66180 6.12138   1.000 46.88554 ? 922 HOH B O   1 
HETATM 2203 O O   . HOH G 5 .   ? -45.87135 19.41585 5.31949   1.000 38.13094 ? 923 HOH B O   1 
HETATM 2204 O O   . HOH G 5 .   ? -56.02869 8.40507  19.15768  1.000 42.07734 ? 924 HOH B O   1 
HETATM 2205 O O   . HOH G 5 .   ? -32.65162 18.09856 19.31188  1.000 46.97582 ? 925 HOH B O   1 
HETATM 2206 O O   . HOH G 5 .   ? -43.819   24.856   32.158    1.000 30.18038 ? 926 HOH B O   1 
HETATM 2207 O O   . HOH G 5 .   ? -53.75831 9.31875  20.03246  1.000 40.58953 ? 927 HOH B O   1 
HETATM 2208 O O   . HOH G 5 .   ? -36.107   22.782   22.977    1.000 31.57285 ? 928 HOH B O   1 
HETATM 2209 O O   . HOH G 5 .   ? -30.01771 17.34010 -18.58019 1.000 37.07790 ? 929 HOH B O   1 
HETATM 2210 O O   . HOH G 5 .   ? -45.712   -6.442   18.817    1.000 39.24836 ? 930 HOH B O   1 
HETATM 2211 O O   . HOH G 5 .   ? -31.497   12.828   35.614    1.000 45.52420 ? 931 HOH B O   1 
HETATM 2212 O O   . HOH G 5 .   ? -36.40260 4.54271  26.35085  1.000 46.77886 ? 932 HOH B O   1 
HETATM 2213 O O   . HOH G 5 .   ? -42.12705 20.12688 36.42704  1.000 35.50537 ? 933 HOH B O   1 
HETATM 2214 O O   . HOH G 5 .   ? -23.14597 17.60702 -4.66713  1.000 26.00179 ? 934 HOH B O   1 
HETATM 2215 O O   . HOH G 5 .   ? -34.17765 13.16851 20.79724  1.000 38.92578 ? 935 HOH B O   1 
HETATM 2216 O O   . HOH G 5 .   ? -31.39313 -1.63825 17.59124  1.000 46.42761 ? 936 HOH B O   1 
HETATM 2217 O O   . HOH G 5 .   ? -37.51313 20.22440 16.99359  1.000 32.96432 ? 937 HOH B O   1 
HETATM 2218 O O   . HOH G 5 .   ? -58.25002 6.76290  18.67277  1.000 45.97407 ? 938 HOH B O   1 
HETATM 2219 O O   . HOH G 5 .   ? -31.540   20.897   23.419    1.000 45.86384 ? 939 HOH B O   1 
HETATM 2220 O O   . HOH G 5 .   ? -23.04801 0.65601  1.16543   1.000 42.39663 ? 940 HOH B O   1 
HETATM 2221 O O   . HOH G 5 .   ? -40.07157 15.00734 -11.82897 1.000 43.19113 ? 941 HOH B O   1 
HETATM 2222 O O   . HOH G 5 .   ? -15.127   16.588   -21.953   1.000 41.25965 ? 942 HOH B O   1 
HETATM 2223 O O   . HOH G 5 .   ? -32.05030 -3.31049 15.83409  1.000 45.15823 ? 943 HOH B O   1 
HETATM 2224 O O   . HOH G 5 .   ? -35.04510 -4.34731 18.64748  1.000 49.63236 ? 944 HOH B O   1 
HETATM 2225 O O   . HOH G 5 .   ? -36.84695 5.97548  30.19494  1.000 47.11914 ? 945 HOH B O   1 
HETATM 2226 O O   . HOH G 5 .   ? -62.44391 12.88692 12.21675  1.000 54.21684 ? 946 HOH B O   1 
HETATM 2227 O O   . HOH G 5 .   ? -62.97954 12.27353 14.38671  1.000 56.38707 ? 947 HOH B O   1 
HETATM 2228 O O   . HOH G 5 .   ? -64.07798 9.63647  22.17215  1.000 61.11046 ? 948 HOH B O   1 
HETATM 2229 O O   . HOH G 5 .   ? -66.11319 8.02697  22.96459  1.000 62.75507 ? 949 HOH B O   1 
# 
