data_8YDQ
# 
_entry.id   8YDQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YDQ         pdb_00008ydq 10.2210/pdb8ydq/pdb 
WWPDB D_1300045365 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YDQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              yoshi.cesp@tmd.ac.jp 
_pdbx_contact_author.name_first         Yoshinori 
_pdbx_contact_author.name_last          Fujiyoshi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8070-1493 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nakamura, S.'  1 0000-0003-2253-6976 
'Numoto, N.'    2 0000-0001-6113-9792 
'Fujiyoshi, Y.' 3 0000-0002-8070-1493 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Development of a short-peptide inhibiting any SARS-CoV-2 variants based on structural biology' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nakamura, S.'  1  0000-0003-2253-6976 
primary 'Tanimura, Y.'  2  ?                   
primary 'Nomura, R.'    3  ?                   
primary 'Suzuki, H.'    4  ?                   
primary 'Nishikawa, K.' 5  ?                   
primary 'Kamegawa, A.'  6  ?                   
primary 'Numoto, N.'    7  ?                   
primary 'Tanaka, A.'    8  ?                   
primary 'Kawabata, S.'  9  ?                   
primary 'Sakaguchi, S.' 10 ?                   
primary 'Emi, A.'       11 ?                   
primary 'Suzuki, Y.'    12 ?                   
primary 'Fujiyoshi, Y.' 13 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 'SARS-CoV-2 inhibiting peptide Ce149' 4772.475  1   ? ? ? ? 
2 polymer     man 'Spike protein S1'                    26304.348 1   ? ? ? ? 
3 non-polymer syn GLYCEROL                              92.094    1   ? ? ? ? 
4 water       nat water                                 18.015    129 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no DKEWILYKIYEIMVRLDEEGHGEASLMVSDLIYEFMKRD DKEWILYKIYEIMVRLDEEGHGEASLMVSDLIYEFMKRD A ? 
2 'polypeptide(L)' no no 
;TNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFSAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAP
GQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPL
RSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
;TNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFSAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAP
GQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPL
RSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 GLYCEROL GOL 
4 water    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   LYS n 
1 3   GLU n 
1 4   TRP n 
1 5   ILE n 
1 6   LEU n 
1 7   TYR n 
1 8   LYS n 
1 9   ILE n 
1 10  TYR n 
1 11  GLU n 
1 12  ILE n 
1 13  MET n 
1 14  VAL n 
1 15  ARG n 
1 16  LEU n 
1 17  ASP n 
1 18  GLU n 
1 19  GLU n 
1 20  GLY n 
1 21  HIS n 
1 22  GLY n 
1 23  GLU n 
1 24  ALA n 
1 25  SER n 
1 26  LEU n 
1 27  MET n 
1 28  VAL n 
1 29  SER n 
1 30  ASP n 
1 31  LEU n 
1 32  ILE n 
1 33  TYR n 
1 34  GLU n 
1 35  PHE n 
1 36  MET n 
1 37  LYS n 
1 38  ARG n 
1 39  ASP n 
2 1   THR n 
2 2   ASN n 
2 3   LEU n 
2 4   CYS n 
2 5   PRO n 
2 6   PHE n 
2 7   ASP n 
2 8   GLU n 
2 9   VAL n 
2 10  PHE n 
2 11  ASN n 
2 12  ALA n 
2 13  THR n 
2 14  ARG n 
2 15  PHE n 
2 16  ALA n 
2 17  SER n 
2 18  VAL n 
2 19  TYR n 
2 20  ALA n 
2 21  TRP n 
2 22  ASN n 
2 23  ARG n 
2 24  LYS n 
2 25  ARG n 
2 26  ILE n 
2 27  SER n 
2 28  ASN n 
2 29  CYS n 
2 30  VAL n 
2 31  ALA n 
2 32  ASP n 
2 33  TYR n 
2 34  SER n 
2 35  VAL n 
2 36  LEU n 
2 37  TYR n 
2 38  ASN n 
2 39  PHE n 
2 40  ALA n 
2 41  PRO n 
2 42  PHE n 
2 43  SER n 
2 44  ALA n 
2 45  PHE n 
2 46  LYS n 
2 47  CYS n 
2 48  TYR n 
2 49  GLY n 
2 50  VAL n 
2 51  SER n 
2 52  PRO n 
2 53  THR n 
2 54  LYS n 
2 55  LEU n 
2 56  ASN n 
2 57  ASP n 
2 58  LEU n 
2 59  CYS n 
2 60  PHE n 
2 61  THR n 
2 62  ASN n 
2 63  VAL n 
2 64  TYR n 
2 65  ALA n 
2 66  ASP n 
2 67  SER n 
2 68  PHE n 
2 69  VAL n 
2 70  ILE n 
2 71  ARG n 
2 72  GLY n 
2 73  ASN n 
2 74  GLU n 
2 75  VAL n 
2 76  SER n 
2 77  GLN n 
2 78  ILE n 
2 79  ALA n 
2 80  PRO n 
2 81  GLY n 
2 82  GLN n 
2 83  THR n 
2 84  GLY n 
2 85  ASN n 
2 86  ILE n 
2 87  ALA n 
2 88  ASP n 
2 89  TYR n 
2 90  ASN n 
2 91  TYR n 
2 92  LYS n 
2 93  LEU n 
2 94  PRO n 
2 95  ASP n 
2 96  ASP n 
2 97  PHE n 
2 98  THR n 
2 99  GLY n 
2 100 CYS n 
2 101 VAL n 
2 102 ILE n 
2 103 ALA n 
2 104 TRP n 
2 105 ASN n 
2 106 SER n 
2 107 ASN n 
2 108 LYS n 
2 109 LEU n 
2 110 ASP n 
2 111 SER n 
2 112 LYS n 
2 113 VAL n 
2 114 GLY n 
2 115 GLY n 
2 116 ASN n 
2 117 TYR n 
2 118 ASN n 
2 119 TYR n 
2 120 LEU n 
2 121 TYR n 
2 122 ARG n 
2 123 LEU n 
2 124 PHE n 
2 125 ARG n 
2 126 LYS n 
2 127 SER n 
2 128 ASN n 
2 129 LEU n 
2 130 LYS n 
2 131 PRO n 
2 132 PHE n 
2 133 GLU n 
2 134 ARG n 
2 135 ASP n 
2 136 ILE n 
2 137 SER n 
2 138 THR n 
2 139 GLU n 
2 140 ILE n 
2 141 TYR n 
2 142 GLN n 
2 143 ALA n 
2 144 GLY n 
2 145 ASN n 
2 146 LYS n 
2 147 PRO n 
2 148 CYS n 
2 149 ASN n 
2 150 GLY n 
2 151 VAL n 
2 152 ALA n 
2 153 GLY n 
2 154 PHE n 
2 155 ASN n 
2 156 CYS n 
2 157 TYR n 
2 158 PHE n 
2 159 PRO n 
2 160 LEU n 
2 161 ARG n 
2 162 SER n 
2 163 TYR n 
2 164 GLY n 
2 165 PHE n 
2 166 ARG n 
2 167 PRO n 
2 168 THR n 
2 169 TYR n 
2 170 GLY n 
2 171 VAL n 
2 172 GLY n 
2 173 HIS n 
2 174 GLN n 
2 175 PRO n 
2 176 TYR n 
2 177 ARG n 
2 178 VAL n 
2 179 VAL n 
2 180 VAL n 
2 181 LEU n 
2 182 SER n 
2 183 PHE n 
2 184 GLU n 
2 185 LEU n 
2 186 LEU n 
2 187 HIS n 
2 188 ALA n 
2 189 PRO n 
2 190 ALA n 
2 191 THR n 
2 192 VAL n 
2 193 CYS n 
2 194 GLY n 
2 195 SER n 
2 196 ASN n 
2 197 SER n 
2 198 GLU n 
2 199 ASN n 
2 200 LEU n 
2 201 TYR n 
2 202 PHE n 
2 203 GLN n 
2 204 GLY n 
2 205 SER n 
2 206 HIS n 
2 207 HIS n 
2 208 HIS n 
2 209 HIS n 
2 210 HIS n 
2 211 HIS n 
2 212 HIS n 
2 213 HIS n 
2 214 HIS n 
2 215 HIS n 
2 216 GLY n 
2 217 LEU n 
2 218 ASN n 
2 219 ASP n 
2 220 ILE n 
2 221 PHE n 
2 222 GLU n 
2 223 ALA n 
2 224 GLN n 
2 225 LYS n 
2 226 ILE n 
2 227 GLU n 
2 228 TRP n 
2 229 HIS n 
2 230 GLU n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   230 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'S, 2' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            Expi293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       39 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   1   1   ASP ASP A . n 
A 1 2   LYS 2   2   2   LYS LYS A . n 
A 1 3   GLU 3   3   3   GLU GLU A . n 
A 1 4   TRP 4   4   4   TRP TRP A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   TYR 7   7   7   TYR TYR A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  TYR 10  10  10  TYR TYR A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  MET 13  13  13  MET MET A . n 
A 1 14  VAL 14  14  14  VAL VAL A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  ASP 17  17  17  ASP ASP A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  HIS 21  21  21  HIS HIS A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  MET 27  27  27  MET MET A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  SER 29  29  29  SER SER A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  TYR 33  33  33  TYR TYR A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
B 2 1   THR 1   333 333 THR THR B . n 
B 2 2   ASN 2   334 334 ASN ASN B . n 
B 2 3   LEU 3   335 335 LEU LEU B . n 
B 2 4   CYS 4   336 336 CYS CYS B . n 
B 2 5   PRO 5   337 337 PRO PRO B . n 
B 2 6   PHE 6   338 338 PHE PHE B . n 
B 2 7   ASP 7   339 339 ASP ASP B . n 
B 2 8   GLU 8   340 340 GLU GLU B . n 
B 2 9   VAL 9   341 341 VAL VAL B . n 
B 2 10  PHE 10  342 342 PHE PHE B . n 
B 2 11  ASN 11  343 343 ASN ASN B . n 
B 2 12  ALA 12  344 344 ALA ALA B . n 
B 2 13  THR 13  345 345 THR THR B . n 
B 2 14  ARG 14  346 346 ARG ARG B . n 
B 2 15  PHE 15  347 347 PHE PHE B . n 
B 2 16  ALA 16  348 348 ALA ALA B . n 
B 2 17  SER 17  349 349 SER SER B . n 
B 2 18  VAL 18  350 350 VAL VAL B . n 
B 2 19  TYR 19  351 351 TYR TYR B . n 
B 2 20  ALA 20  352 352 ALA ALA B . n 
B 2 21  TRP 21  353 353 TRP TRP B . n 
B 2 22  ASN 22  354 354 ASN ASN B . n 
B 2 23  ARG 23  355 355 ARG ARG B . n 
B 2 24  LYS 24  356 356 LYS LYS B . n 
B 2 25  ARG 25  357 357 ARG ARG B . n 
B 2 26  ILE 26  358 358 ILE ILE B . n 
B 2 27  SER 27  359 359 SER SER B . n 
B 2 28  ASN 28  360 360 ASN ASN B . n 
B 2 29  CYS 29  361 361 CYS CYS B . n 
B 2 30  VAL 30  362 362 VAL VAL B . n 
B 2 31  ALA 31  363 363 ALA ALA B . n 
B 2 32  ASP 32  364 364 ASP ASP B . n 
B 2 33  TYR 33  365 365 TYR TYR B . n 
B 2 34  SER 34  366 366 SER SER B . n 
B 2 35  VAL 35  367 367 VAL VAL B . n 
B 2 36  LEU 36  368 368 LEU LEU B . n 
B 2 37  TYR 37  369 369 TYR TYR B . n 
B 2 38  ASN 38  370 370 ASN ASN B . n 
B 2 39  PHE 39  371 371 PHE PHE B . n 
B 2 40  ALA 40  372 372 ALA ALA B . n 
B 2 41  PRO 41  373 373 PRO PRO B . n 
B 2 42  PHE 42  374 374 PHE PHE B . n 
B 2 43  SER 43  375 375 SER SER B . n 
B 2 44  ALA 44  376 376 ALA ALA B . n 
B 2 45  PHE 45  377 377 PHE PHE B . n 
B 2 46  LYS 46  378 378 LYS LYS B . n 
B 2 47  CYS 47  379 379 CYS CYS B . n 
B 2 48  TYR 48  380 380 TYR TYR B . n 
B 2 49  GLY 49  381 381 GLY GLY B . n 
B 2 50  VAL 50  382 382 VAL VAL B . n 
B 2 51  SER 51  383 383 SER SER B . n 
B 2 52  PRO 52  384 384 PRO PRO B . n 
B 2 53  THR 53  385 385 THR THR B . n 
B 2 54  LYS 54  386 386 LYS LYS B . n 
B 2 55  LEU 55  387 387 LEU LEU B . n 
B 2 56  ASN 56  388 388 ASN ASN B . n 
B 2 57  ASP 57  389 389 ASP ASP B . n 
B 2 58  LEU 58  390 390 LEU LEU B . n 
B 2 59  CYS 59  391 391 CYS CYS B . n 
B 2 60  PHE 60  392 392 PHE PHE B . n 
B 2 61  THR 61  393 393 THR THR B . n 
B 2 62  ASN 62  394 394 ASN ASN B . n 
B 2 63  VAL 63  395 395 VAL VAL B . n 
B 2 64  TYR 64  396 396 TYR TYR B . n 
B 2 65  ALA 65  397 397 ALA ALA B . n 
B 2 66  ASP 66  398 398 ASP ASP B . n 
B 2 67  SER 67  399 399 SER SER B . n 
B 2 68  PHE 68  400 400 PHE PHE B . n 
B 2 69  VAL 69  401 401 VAL VAL B . n 
B 2 70  ILE 70  402 402 ILE ILE B . n 
B 2 71  ARG 71  403 403 ARG ARG B . n 
B 2 72  GLY 72  404 404 GLY GLY B . n 
B 2 73  ASN 73  405 405 ASN ASN B . n 
B 2 74  GLU 74  406 406 GLU GLU B . n 
B 2 75  VAL 75  407 407 VAL VAL B . n 
B 2 76  SER 76  408 408 SER SER B . n 
B 2 77  GLN 77  409 409 GLN GLN B . n 
B 2 78  ILE 78  410 410 ILE ILE B . n 
B 2 79  ALA 79  411 411 ALA ALA B . n 
B 2 80  PRO 80  412 412 PRO PRO B . n 
B 2 81  GLY 81  413 413 GLY GLY B . n 
B 2 82  GLN 82  414 414 GLN GLN B . n 
B 2 83  THR 83  415 415 THR THR B . n 
B 2 84  GLY 84  416 416 GLY GLY B . n 
B 2 85  ASN 85  417 417 ASN ASN B . n 
B 2 86  ILE 86  418 418 ILE ILE B . n 
B 2 87  ALA 87  419 419 ALA ALA B . n 
B 2 88  ASP 88  420 420 ASP ASP B . n 
B 2 89  TYR 89  421 421 TYR TYR B . n 
B 2 90  ASN 90  422 422 ASN ASN B . n 
B 2 91  TYR 91  423 423 TYR TYR B . n 
B 2 92  LYS 92  424 424 LYS LYS B . n 
B 2 93  LEU 93  425 425 LEU LEU B . n 
B 2 94  PRO 94  426 426 PRO PRO B . n 
B 2 95  ASP 95  427 427 ASP ASP B . n 
B 2 96  ASP 96  428 428 ASP ASP B . n 
B 2 97  PHE 97  429 429 PHE PHE B . n 
B 2 98  THR 98  430 430 THR THR B . n 
B 2 99  GLY 99  431 431 GLY GLY B . n 
B 2 100 CYS 100 432 432 CYS CYS B . n 
B 2 101 VAL 101 433 433 VAL VAL B . n 
B 2 102 ILE 102 434 434 ILE ILE B . n 
B 2 103 ALA 103 435 435 ALA ALA B . n 
B 2 104 TRP 104 436 436 TRP TRP B . n 
B 2 105 ASN 105 437 437 ASN ASN B . n 
B 2 106 SER 106 438 438 SER SER B . n 
B 2 107 ASN 107 439 439 ASN ASN B . n 
B 2 108 LYS 108 440 440 LYS LYS B . n 
B 2 109 LEU 109 441 441 LEU LEU B . n 
B 2 110 ASP 110 442 442 ASP ASP B . n 
B 2 111 SER 111 443 443 SER SER B . n 
B 2 112 LYS 112 444 444 LYS LYS B . n 
B 2 113 VAL 113 445 445 VAL VAL B . n 
B 2 114 GLY 114 446 446 GLY GLY B . n 
B 2 115 GLY 115 447 447 GLY GLY B . n 
B 2 116 ASN 116 448 448 ASN ASN B . n 
B 2 117 TYR 117 449 449 TYR TYR B . n 
B 2 118 ASN 118 450 450 ASN ASN B . n 
B 2 119 TYR 119 451 451 TYR TYR B . n 
B 2 120 LEU 120 452 452 LEU LEU B . n 
B 2 121 TYR 121 453 453 TYR TYR B . n 
B 2 122 ARG 122 454 454 ARG ARG B . n 
B 2 123 LEU 123 455 455 LEU LEU B . n 
B 2 124 PHE 124 456 456 PHE PHE B . n 
B 2 125 ARG 125 457 457 ARG ARG B . n 
B 2 126 LYS 126 458 458 LYS LYS B . n 
B 2 127 SER 127 459 459 SER SER B . n 
B 2 128 ASN 128 460 460 ASN ASN B . n 
B 2 129 LEU 129 461 461 LEU LEU B . n 
B 2 130 LYS 130 462 462 LYS LYS B . n 
B 2 131 PRO 131 463 463 PRO PRO B . n 
B 2 132 PHE 132 464 464 PHE PHE B . n 
B 2 133 GLU 133 465 465 GLU GLU B . n 
B 2 134 ARG 134 466 466 ARG ARG B . n 
B 2 135 ASP 135 467 467 ASP ASP B . n 
B 2 136 ILE 136 468 468 ILE ILE B . n 
B 2 137 SER 137 469 469 SER SER B . n 
B 2 138 THR 138 470 470 THR THR B . n 
B 2 139 GLU 139 471 471 GLU ALA B . n 
B 2 140 ILE 140 472 472 ILE ILE B . n 
B 2 141 TYR 141 473 473 TYR TYR B . n 
B 2 142 GLN 142 474 474 GLN GLN B . n 
B 2 143 ALA 143 475 475 ALA ALA B . n 
B 2 144 GLY 144 476 476 GLY GLY B . n 
B 2 145 ASN 145 477 477 ASN ASN B . n 
B 2 146 LYS 146 478 478 LYS LYS B . n 
B 2 147 PRO 147 479 479 PRO PRO B . n 
B 2 148 CYS 148 480 480 CYS CYS B . n 
B 2 149 ASN 149 481 481 ASN ASN B . n 
B 2 150 GLY 150 482 482 GLY GLY B . n 
B 2 151 VAL 151 483 483 VAL VAL B . n 
B 2 152 ALA 152 484 484 ALA ALA B . n 
B 2 153 GLY 153 485 485 GLY GLY B . n 
B 2 154 PHE 154 486 486 PHE PHE B . n 
B 2 155 ASN 155 487 487 ASN ASN B . n 
B 2 156 CYS 156 488 488 CYS CYS B . n 
B 2 157 TYR 157 489 489 TYR TYR B . n 
B 2 158 PHE 158 490 490 PHE PHE B . n 
B 2 159 PRO 159 491 491 PRO PRO B . n 
B 2 160 LEU 160 492 492 LEU LEU B . n 
B 2 161 ARG 161 493 493 ARG ARG B . n 
B 2 162 SER 162 494 494 SER SER B . n 
B 2 163 TYR 163 495 495 TYR TYR B . n 
B 2 164 GLY 164 496 496 GLY GLY B . n 
B 2 165 PHE 165 497 497 PHE PHE B . n 
B 2 166 ARG 166 498 498 ARG ARG B . n 
B 2 167 PRO 167 499 499 PRO PRO B . n 
B 2 168 THR 168 500 500 THR THR B . n 
B 2 169 TYR 169 501 501 TYR TYR B . n 
B 2 170 GLY 170 502 502 GLY GLY B . n 
B 2 171 VAL 171 503 503 VAL VAL B . n 
B 2 172 GLY 172 504 504 GLY GLY B . n 
B 2 173 HIS 173 505 505 HIS HIS B . n 
B 2 174 GLN 174 506 506 GLN GLN B . n 
B 2 175 PRO 175 507 507 PRO PRO B . n 
B 2 176 TYR 176 508 508 TYR TYR B . n 
B 2 177 ARG 177 509 509 ARG ARG B . n 
B 2 178 VAL 178 510 510 VAL VAL B . n 
B 2 179 VAL 179 511 511 VAL VAL B . n 
B 2 180 VAL 180 512 512 VAL VAL B . n 
B 2 181 LEU 181 513 513 LEU LEU B . n 
B 2 182 SER 182 514 514 SER SER B . n 
B 2 183 PHE 183 515 515 PHE PHE B . n 
B 2 184 GLU 184 516 516 GLU GLU B . n 
B 2 185 LEU 185 517 517 LEU LEU B . n 
B 2 186 LEU 186 518 518 LEU LEU B . n 
B 2 187 HIS 187 519 519 HIS HIS B . n 
B 2 188 ALA 188 520 520 ALA ALA B . n 
B 2 189 PRO 189 521 521 PRO PRO B . n 
B 2 190 ALA 190 522 522 ALA ALA B . n 
B 2 191 THR 191 523 523 THR THR B . n 
B 2 192 VAL 192 524 524 VAL VAL B . n 
B 2 193 CYS 193 525 525 CYS CYS B . n 
B 2 194 GLY 194 526 526 GLY GLY B . n 
B 2 195 SER 195 527 527 SER SER B . n 
B 2 196 ASN 196 528 528 ASN ASN B . n 
B 2 197 SER 197 529 ?   ?   ?   B . n 
B 2 198 GLU 198 530 ?   ?   ?   B . n 
B 2 199 ASN 199 531 ?   ?   ?   B . n 
B 2 200 LEU 200 532 ?   ?   ?   B . n 
B 2 201 TYR 201 533 ?   ?   ?   B . n 
B 2 202 PHE 202 534 ?   ?   ?   B . n 
B 2 203 GLN 203 535 ?   ?   ?   B . n 
B 2 204 GLY 204 536 ?   ?   ?   B . n 
B 2 205 SER 205 537 ?   ?   ?   B . n 
B 2 206 HIS 206 538 ?   ?   ?   B . n 
B 2 207 HIS 207 539 ?   ?   ?   B . n 
B 2 208 HIS 208 540 ?   ?   ?   B . n 
B 2 209 HIS 209 541 ?   ?   ?   B . n 
B 2 210 HIS 210 542 ?   ?   ?   B . n 
B 2 211 HIS 211 543 ?   ?   ?   B . n 
B 2 212 HIS 212 544 ?   ?   ?   B . n 
B 2 213 HIS 213 545 ?   ?   ?   B . n 
B 2 214 HIS 214 546 ?   ?   ?   B . n 
B 2 215 HIS 215 547 ?   ?   ?   B . n 
B 2 216 GLY 216 548 ?   ?   ?   B . n 
B 2 217 LEU 217 549 ?   ?   ?   B . n 
B 2 218 ASN 218 550 ?   ?   ?   B . n 
B 2 219 ASP 219 551 ?   ?   ?   B . n 
B 2 220 ILE 220 552 ?   ?   ?   B . n 
B 2 221 PHE 221 553 ?   ?   ?   B . n 
B 2 222 GLU 222 554 ?   ?   ?   B . n 
B 2 223 ALA 223 555 ?   ?   ?   B . n 
B 2 224 GLN 224 556 ?   ?   ?   B . n 
B 2 225 LYS 225 557 ?   ?   ?   B . n 
B 2 226 ILE 226 558 ?   ?   ?   B . n 
B 2 227 GLU 227 559 ?   ?   ?   B . n 
B 2 228 TRP 228 560 ?   ?   ?   B . n 
B 2 229 HIS 229 561 ?   ?   ?   B . n 
B 2 230 GLU 230 562 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 GOL 1   601 101 GOL GOL B . 
D 4 HOH 1   101 56  HOH HOH A . 
D 4 HOH 2   102 103 HOH HOH A . 
D 4 HOH 3   103 29  HOH HOH A . 
D 4 HOH 4   104 52  HOH HOH A . 
D 4 HOH 5   105 4   HOH HOH A . 
D 4 HOH 6   106 104 HOH HOH A . 
D 4 HOH 7   107 71  HOH HOH A . 
D 4 HOH 8   108 45  HOH HOH A . 
D 4 HOH 9   109 111 HOH HOH A . 
D 4 HOH 10  110 2   HOH HOH A . 
D 4 HOH 11  111 33  HOH HOH A . 
D 4 HOH 12  112 34  HOH HOH A . 
D 4 HOH 13  113 63  HOH HOH A . 
D 4 HOH 14  114 64  HOH HOH A . 
D 4 HOH 15  115 92  HOH HOH A . 
D 4 HOH 16  116 115 HOH HOH A . 
D 4 HOH 17  117 142 HOH HOH A . 
D 4 HOH 18  118 108 HOH HOH A . 
D 4 HOH 19  119 62  HOH HOH A . 
D 4 HOH 20  120 74  HOH HOH A . 
D 4 HOH 21  121 102 HOH HOH A . 
D 4 HOH 22  122 26  HOH HOH A . 
D 4 HOH 23  123 94  HOH HOH A . 
E 4 HOH 1   701 46  HOH HOH B . 
E 4 HOH 2   702 132 HOH HOH B . 
E 4 HOH 3   703 37  HOH HOH B . 
E 4 HOH 4   704 1   HOH HOH B . 
E 4 HOH 5   705 85  HOH HOH B . 
E 4 HOH 6   706 36  HOH HOH B . 
E 4 HOH 7   707 23  HOH HOH B . 
E 4 HOH 8   708 58  HOH HOH B . 
E 4 HOH 9   709 3   HOH HOH B . 
E 4 HOH 10  710 88  HOH HOH B . 
E 4 HOH 11  711 99  HOH HOH B . 
E 4 HOH 12  712 40  HOH HOH B . 
E 4 HOH 13  713 65  HOH HOH B . 
E 4 HOH 14  714 129 HOH HOH B . 
E 4 HOH 15  715 12  HOH HOH B . 
E 4 HOH 16  716 109 HOH HOH B . 
E 4 HOH 17  717 11  HOH HOH B . 
E 4 HOH 18  718 20  HOH HOH B . 
E 4 HOH 19  719 28  HOH HOH B . 
E 4 HOH 20  720 13  HOH HOH B . 
E 4 HOH 21  721 106 HOH HOH B . 
E 4 HOH 22  722 41  HOH HOH B . 
E 4 HOH 23  723 47  HOH HOH B . 
E 4 HOH 24  724 112 HOH HOH B . 
E 4 HOH 25  725 128 HOH HOH B . 
E 4 HOH 26  726 67  HOH HOH B . 
E 4 HOH 27  727 27  HOH HOH B . 
E 4 HOH 28  728 96  HOH HOH B . 
E 4 HOH 29  729 16  HOH HOH B . 
E 4 HOH 30  730 18  HOH HOH B . 
E 4 HOH 31  731 72  HOH HOH B . 
E 4 HOH 32  732 8   HOH HOH B . 
E 4 HOH 33  733 51  HOH HOH B . 
E 4 HOH 34  734 48  HOH HOH B . 
E 4 HOH 35  735 55  HOH HOH B . 
E 4 HOH 36  736 19  HOH HOH B . 
E 4 HOH 37  737 145 HOH HOH B . 
E 4 HOH 38  738 10  HOH HOH B . 
E 4 HOH 39  739 32  HOH HOH B . 
E 4 HOH 40  740 39  HOH HOH B . 
E 4 HOH 41  741 5   HOH HOH B . 
E 4 HOH 42  742 14  HOH HOH B . 
E 4 HOH 43  743 25  HOH HOH B . 
E 4 HOH 44  744 22  HOH HOH B . 
E 4 HOH 45  745 97  HOH HOH B . 
E 4 HOH 46  746 107 HOH HOH B . 
E 4 HOH 47  747 7   HOH HOH B . 
E 4 HOH 48  748 6   HOH HOH B . 
E 4 HOH 49  749 30  HOH HOH B . 
E 4 HOH 50  750 136 HOH HOH B . 
E 4 HOH 51  751 110 HOH HOH B . 
E 4 HOH 52  752 105 HOH HOH B . 
E 4 HOH 53  753 123 HOH HOH B . 
E 4 HOH 54  754 130 HOH HOH B . 
E 4 HOH 55  755 15  HOH HOH B . 
E 4 HOH 56  756 100 HOH HOH B . 
E 4 HOH 57  757 59  HOH HOH B . 
E 4 HOH 58  758 89  HOH HOH B . 
E 4 HOH 59  759 17  HOH HOH B . 
E 4 HOH 60  760 90  HOH HOH B . 
E 4 HOH 61  761 124 HOH HOH B . 
E 4 HOH 62  762 24  HOH HOH B . 
E 4 HOH 63  763 93  HOH HOH B . 
E 4 HOH 64  764 21  HOH HOH B . 
E 4 HOH 65  765 101 HOH HOH B . 
E 4 HOH 66  766 60  HOH HOH B . 
E 4 HOH 67  767 44  HOH HOH B . 
E 4 HOH 68  768 49  HOH HOH B . 
E 4 HOH 69  769 35  HOH HOH B . 
E 4 HOH 70  770 87  HOH HOH B . 
E 4 HOH 71  771 38  HOH HOH B . 
E 4 HOH 72  772 66  HOH HOH B . 
E 4 HOH 73  773 121 HOH HOH B . 
E 4 HOH 74  774 75  HOH HOH B . 
E 4 HOH 75  775 9   HOH HOH B . 
E 4 HOH 76  776 57  HOH HOH B . 
E 4 HOH 77  777 79  HOH HOH B . 
E 4 HOH 78  778 69  HOH HOH B . 
E 4 HOH 79  779 137 HOH HOH B . 
E 4 HOH 80  780 73  HOH HOH B . 
E 4 HOH 81  781 83  HOH HOH B . 
E 4 HOH 82  782 50  HOH HOH B . 
E 4 HOH 83  783 43  HOH HOH B . 
E 4 HOH 84  784 140 HOH HOH B . 
E 4 HOH 85  785 143 HOH HOH B . 
E 4 HOH 86  786 117 HOH HOH B . 
E 4 HOH 87  787 120 HOH HOH B . 
E 4 HOH 88  788 82  HOH HOH B . 
E 4 HOH 89  789 31  HOH HOH B . 
E 4 HOH 90  790 70  HOH HOH B . 
E 4 HOH 91  791 127 HOH HOH B . 
E 4 HOH 92  792 144 HOH HOH B . 
E 4 HOH 93  793 118 HOH HOH B . 
E 4 HOH 94  794 54  HOH HOH B . 
E 4 HOH 95  795 119 HOH HOH B . 
E 4 HOH 96  796 122 HOH HOH B . 
E 4 HOH 97  797 42  HOH HOH B . 
E 4 HOH 98  798 77  HOH HOH B . 
E 4 HOH 99  799 81  HOH HOH B . 
E 4 HOH 100 800 76  HOH HOH B . 
E 4 HOH 101 801 113 HOH HOH B . 
E 4 HOH 102 802 80  HOH HOH B . 
E 4 HOH 103 803 53  HOH HOH B . 
E 4 HOH 104 804 141 HOH HOH B . 
E 4 HOH 105 805 84  HOH HOH B . 
E 4 HOH 106 806 86  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B TYR 369 ? CG  ? B TYR 37  CG  
2  1 Y 1 B TYR 369 ? CD1 ? B TYR 37  CD1 
3  1 Y 1 B TYR 369 ? CD2 ? B TYR 37  CD2 
4  1 Y 1 B TYR 369 ? CE1 ? B TYR 37  CE1 
5  1 Y 1 B TYR 369 ? CE2 ? B TYR 37  CE2 
6  1 Y 1 B TYR 369 ? CZ  ? B TYR 37  CZ  
7  1 Y 1 B TYR 369 ? OH  ? B TYR 37  OH  
8  1 Y 1 B ASN 370 ? CG  ? B ASN 38  CG  
9  1 Y 1 B ASN 370 ? OD1 ? B ASN 38  OD1 
10 1 Y 1 B ASN 370 ? ND2 ? B ASN 38  ND2 
11 1 Y 1 B GLU 471 ? CG  ? B GLU 139 CG  
12 1 Y 1 B GLU 471 ? CD  ? B GLU 139 CD  
13 1 Y 1 B GLU 471 ? OE1 ? B GLU 139 OE1 
14 1 Y 1 B GLU 471 ? OE2 ? B GLU 139 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YDQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.860 
_cell.length_a_esd                 ? 
_cell.length_b                     74.860 
_cell.length_b_esd                 ? 
_cell.length_c                     100.580 
_cell.length_c_esd                 ? 
_cell.volume                       488137.203 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YDQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YDQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.62 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          53.02 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M sodium thiocyanate, 20% PEG 6000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-06-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          36.02 
_reflns.entry_id                                       8YDQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.56 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     46951 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.97 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.56 
_reflns_shell.d_res_low                                     1.65 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             7145 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.524 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               46.76 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YDQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             39.74 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26065 
_refine.ls_number_reflns_R_free                  1295 
_refine.ls_number_reflns_R_work                  24770 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.33 
_refine.ls_percent_reflns_R_free                 4.97 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2278 
_refine.ls_R_factor_R_free                       0.2493 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2266 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 34.7113 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2380 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        39.74 
_refine_hist.number_atoms_solvent             129 
_refine_hist.number_atoms_total               2014 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1879 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         6 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0030  ? 1935 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5248  ? 2624 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0443  ? 274  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0043  ? 341  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.0602 ? 692  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.98  . . 141 2696 98.71 . . . . 0.3413 . . . . . . . . . . . 0.3909 
'X-RAY DIFFRACTION' 1.98 2.07  . . 141 2673 98.74 . . . . 0.2978 . . . . . . . . . . . 0.3223 
'X-RAY DIFFRACTION' 2.07 2.17  . . 140 2705 98.55 . . . . 0.2809 . . . . . . . . . . . 0.2997 
'X-RAY DIFFRACTION' 2.18 2.31  . . 143 2717 99.17 . . . . 0.2762 . . . . . . . . . . . 0.3239 
'X-RAY DIFFRACTION' 2.31 2.49  . . 144 2732 99.48 . . . . 0.2593 . . . . . . . . . . . 0.2997 
'X-RAY DIFFRACTION' 2.49 2.74  . . 142 2747 99.83 . . . . 0.2594 . . . . . . . . . . . 0.3263 
'X-RAY DIFFRACTION' 2.74 3.14  . . 146 2778 99.73 . . . . 0.2497 . . . . . . . . . . . 0.2735 
'X-RAY DIFFRACTION' 3.14 3.95  . . 143 2798 99.90 . . . . 0.2253 . . . . . . . . . . . 0.2421 
'X-RAY DIFFRACTION' 3.95 39.74 . . 155 2924 99.81 . . . . 0.1747 . . . . . . . . . . . 0.1825 
# 
_struct.entry_id                     8YDQ 
_struct.title                        
'Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.2 variant spike protein in complex with Ce149' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YDQ 
_struct_keywords.text            'RBD, VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8YDQ        8YDQ   ? 1 ? 1   
2 UNP SPIKE_SARS2 P0DTC2 ? 2 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
;
333 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YDQ A 1 ? 39  ? 8YDQ   1   ? 39  ? 1   39  
2 2 8YDQ B 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8YDQ ASP B 7   ? UNP P0DTC2 GLY 339 variant          339 1  
2 8YDQ PHE B 39  ? UNP P0DTC2 SER 371 variant          371 2  
2 8YDQ PRO B 41  ? UNP P0DTC2 SER 373 variant          373 3  
2 8YDQ ALA B 44  ? UNP P0DTC2 THR 376 variant          376 4  
2 8YDQ ASN B 73  ? UNP P0DTC2 ASP 405 variant          405 5  
2 8YDQ SER B 76  ? UNP P0DTC2 ARG 408 variant          408 6  
2 8YDQ ASN B 85  ? UNP P0DTC2 LYS 417 variant          417 7  
2 8YDQ LYS B 108 ? UNP P0DTC2 ASN 440 variant          440 8  
2 8YDQ ASN B 145 ? UNP P0DTC2 SER 477 variant          477 9  
2 8YDQ LYS B 146 ? UNP P0DTC2 THR 478 variant          478 10 
2 8YDQ ALA B 152 ? UNP P0DTC2 GLU 484 variant          484 11 
2 8YDQ ARG B 161 ? UNP P0DTC2 GLN 493 variant          493 12 
2 8YDQ ARG B 166 ? UNP P0DTC2 GLN 498 variant          498 13 
2 8YDQ TYR B 169 ? UNP P0DTC2 ASN 501 variant          501 14 
2 8YDQ HIS B 173 ? UNP P0DTC2 TYR 505 variant          505 15 
2 8YDQ SER B 195 ? UNP P0DTC2 ?   ?   'expression tag' 527 16 
2 8YDQ ASN B 196 ? UNP P0DTC2 ?   ?   'expression tag' 528 17 
2 8YDQ SER B 197 ? UNP P0DTC2 ?   ?   'expression tag' 529 18 
2 8YDQ GLU B 198 ? UNP P0DTC2 ?   ?   'expression tag' 530 19 
2 8YDQ ASN B 199 ? UNP P0DTC2 ?   ?   'expression tag' 531 20 
2 8YDQ LEU B 200 ? UNP P0DTC2 ?   ?   'expression tag' 532 21 
2 8YDQ TYR B 201 ? UNP P0DTC2 ?   ?   'expression tag' 533 22 
2 8YDQ PHE B 202 ? UNP P0DTC2 ?   ?   'expression tag' 534 23 
2 8YDQ GLN B 203 ? UNP P0DTC2 ?   ?   'expression tag' 535 24 
2 8YDQ GLY B 204 ? UNP P0DTC2 ?   ?   'expression tag' 536 25 
2 8YDQ SER B 205 ? UNP P0DTC2 ?   ?   'expression tag' 537 26 
2 8YDQ HIS B 206 ? UNP P0DTC2 ?   ?   'expression tag' 538 27 
2 8YDQ HIS B 207 ? UNP P0DTC2 ?   ?   'expression tag' 539 28 
2 8YDQ HIS B 208 ? UNP P0DTC2 ?   ?   'expression tag' 540 29 
2 8YDQ HIS B 209 ? UNP P0DTC2 ?   ?   'expression tag' 541 30 
2 8YDQ HIS B 210 ? UNP P0DTC2 ?   ?   'expression tag' 542 31 
2 8YDQ HIS B 211 ? UNP P0DTC2 ?   ?   'expression tag' 543 32 
2 8YDQ HIS B 212 ? UNP P0DTC2 ?   ?   'expression tag' 544 33 
2 8YDQ HIS B 213 ? UNP P0DTC2 ?   ?   'expression tag' 545 34 
2 8YDQ HIS B 214 ? UNP P0DTC2 ?   ?   'expression tag' 546 35 
2 8YDQ HIS B 215 ? UNP P0DTC2 ?   ?   'expression tag' 547 36 
2 8YDQ GLY B 216 ? UNP P0DTC2 ?   ?   'expression tag' 548 37 
2 8YDQ LEU B 217 ? UNP P0DTC2 ?   ?   'expression tag' 549 38 
2 8YDQ ASN B 218 ? UNP P0DTC2 ?   ?   'expression tag' 550 39 
2 8YDQ ASP B 219 ? UNP P0DTC2 ?   ?   'expression tag' 551 40 
2 8YDQ ILE B 220 ? UNP P0DTC2 ?   ?   'expression tag' 552 41 
2 8YDQ PHE B 221 ? UNP P0DTC2 ?   ?   'expression tag' 553 42 
2 8YDQ GLU B 222 ? UNP P0DTC2 ?   ?   'expression tag' 554 43 
2 8YDQ ALA B 223 ? UNP P0DTC2 ?   ?   'expression tag' 555 44 
2 8YDQ GLN B 224 ? UNP P0DTC2 ?   ?   'expression tag' 556 45 
2 8YDQ LYS B 225 ? UNP P0DTC2 ?   ?   'expression tag' 557 46 
2 8YDQ ILE B 226 ? UNP P0DTC2 ?   ?   'expression tag' 558 47 
2 8YDQ GLU B 227 ? UNP P0DTC2 ?   ?   'expression tag' 559 48 
2 8YDQ TRP B 228 ? UNP P0DTC2 ?   ?   'expression tag' 560 49 
2 8YDQ HIS B 229 ? UNP P0DTC2 ?   ?   'expression tag' 561 50 
2 8YDQ GLU B 230 ? UNP P0DTC2 ?   ?   'expression tag' 562 51 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 1   ? GLU A 19  ? ASP A 1   GLU A 19  1 ? 19 
HELX_P HELX_P2  AA2 HIS A 21  ? LYS A 37  ? HIS A 21  LYS A 37  1 ? 17 
HELX_P HELX_P3  AA3 PRO B 5   ? ASN B 11  ? PRO B 337 ASN B 343 1 ? 7  
HELX_P HELX_P4  AA4 SER B 17  ? TRP B 21  ? SER B 349 TRP B 353 5 ? 5  
HELX_P HELX_P5  AA5 TYR B 33  ? ASN B 38  ? TYR B 365 ASN B 370 1 ? 6  
HELX_P HELX_P6  AA6 SER B 51  ? ASP B 57  ? SER B 383 ASP B 389 5 ? 7  
HELX_P HELX_P7  AA7 ASN B 73  ? ILE B 78  ? ASN B 405 ILE B 410 5 ? 6  
HELX_P HELX_P8  AA8 GLY B 84  ? ASN B 90  ? GLY B 416 ASN B 422 1 ? 7  
HELX_P HELX_P9  AA9 SER B 106 ? SER B 111 ? SER B 438 SER B 443 1 ? 6  
HELX_P HELX_P10 AB1 GLY B 170 ? HIS B 173 ? GLY B 502 HIS B 505 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? B CYS 4   SG ? ? ? 1_555 B CYS 29  SG ? ? B CYS 336 B CYS 361 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
disulf2 disulf ? ? B CYS 47  SG ? ? ? 1_555 B CYS 100 SG ? ? B CYS 379 B CYS 432 1_555 ? ? ? ? ? ? ? 2.040 ? ? 
disulf3 disulf ? ? B CYS 59  SG ? ? ? 1_555 B CYS 193 SG ? ? B CYS 391 B CYS 525 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf4 disulf ? ? B CYS 148 SG ? ? ? 1_555 B CYS 156 SG ? ? B CYS 480 B CYS 488 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS B 4   ? CYS B 29  ? CYS B 336 ? 1_555 CYS B 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 47  ? CYS B 100 ? CYS B 379 ? 1_555 CYS B 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 59  ? CYS B 193 ? CYS B 391 ? 1_555 CYS B 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 148 ? CYS B 156 ? CYS B 480 ? 1_555 CYS B 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN B 2   ? LEU B 3   ? ASN B 334 LEU B 335 
AA1 2 CYS B 29  ? ALA B 31  ? CYS B 361 ALA B 363 
AA1 3 VAL B 192 ? GLY B 194 ? VAL B 524 GLY B 526 
AA1 4 CYS B 59  ? PHE B 60  ? CYS B 391 PHE B 392 
AA2 1 ASN B 22  ? ILE B 26  ? ASN B 354 ILE B 358 
AA2 2 ASN B 62  ? ARG B 71  ? ASN B 394 ARG B 403 
AA2 3 PRO B 175 ? GLU B 184 ? PRO B 507 GLU B 516 
AA2 4 GLY B 99  ? ASN B 105 ? GLY B 431 ASN B 437 
AA2 5 ALA B 44  ? TYR B 48  ? ALA B 376 TYR B 380 
AA3 1 LEU B 120 ? ARG B 122 ? LEU B 452 ARG B 454 
AA3 2 LEU B 160 ? SER B 162 ? LEU B 492 SER B 494 
AA4 1 TYR B 141 ? GLN B 142 ? TYR B 473 GLN B 474 
AA4 2 CYS B 156 ? TYR B 157 ? CYS B 488 TYR B 489 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN B 2   ? N ASN B 334 O VAL B 30  ? O VAL B 362 
AA1 2 3 N ALA B 31  ? N ALA B 363 O CYS B 193 ? O CYS B 525 
AA1 3 4 O VAL B 192 ? O VAL B 524 N PHE B 60  ? N PHE B 392 
AA2 1 2 N ILE B 26  ? N ILE B 358 O VAL B 63  ? O VAL B 395 
AA2 2 3 N ASP B 66  ? N ASP B 398 O VAL B 180 ? O VAL B 512 
AA2 3 4 O VAL B 179 ? O VAL B 511 N ILE B 102 ? N ILE B 434 
AA2 4 5 O GLY B 99  ? O GLY B 431 N TYR B 48  ? N TYR B 380 
AA3 1 2 N TYR B 121 ? N TYR B 453 O ARG B 161 ? O ARG B 493 
AA4 1 2 N TYR B 141 ? N TYR B 473 O TYR B 157 ? O TYR B 489 
# 
_pdbx_entry_details.entry_id                   8YDQ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS A 21  ? ? -109.27 59.63  
2 1 PRO B 373 ? ? -69.50  96.04  
3 1 PHE B 377 ? ? -165.31 98.03  
4 1 ASN B 422 ? ? -129.61 -60.22 
5 1 ASP B 428 ? ? -91.61  32.59  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B SER 529 ? B SER 197 
2  1 Y 1 B GLU 530 ? B GLU 198 
3  1 Y 1 B ASN 531 ? B ASN 199 
4  1 Y 1 B LEU 532 ? B LEU 200 
5  1 Y 1 B TYR 533 ? B TYR 201 
6  1 Y 1 B PHE 534 ? B PHE 202 
7  1 Y 1 B GLN 535 ? B GLN 203 
8  1 Y 1 B GLY 536 ? B GLY 204 
9  1 Y 1 B SER 537 ? B SER 205 
10 1 Y 1 B HIS 538 ? B HIS 206 
11 1 Y 1 B HIS 539 ? B HIS 207 
12 1 Y 1 B HIS 540 ? B HIS 208 
13 1 Y 1 B HIS 541 ? B HIS 209 
14 1 Y 1 B HIS 542 ? B HIS 210 
15 1 Y 1 B HIS 543 ? B HIS 211 
16 1 Y 1 B HIS 544 ? B HIS 212 
17 1 Y 1 B HIS 545 ? B HIS 213 
18 1 Y 1 B HIS 546 ? B HIS 214 
19 1 Y 1 B HIS 547 ? B HIS 215 
20 1 Y 1 B GLY 548 ? B GLY 216 
21 1 Y 1 B LEU 549 ? B LEU 217 
22 1 Y 1 B ASN 550 ? B ASN 218 
23 1 Y 1 B ASP 551 ? B ASP 219 
24 1 Y 1 B ILE 552 ? B ILE 220 
25 1 Y 1 B PHE 553 ? B PHE 221 
26 1 Y 1 B GLU 554 ? B GLU 222 
27 1 Y 1 B ALA 555 ? B ALA 223 
28 1 Y 1 B GLN 556 ? B GLN 224 
29 1 Y 1 B LYS 557 ? B LYS 225 
30 1 Y 1 B ILE 558 ? B ILE 226 
31 1 Y 1 B GLU 559 ? B GLU 227 
32 1 Y 1 B TRP 560 ? B TRP 228 
33 1 Y 1 B HIS 561 ? B HIS 229 
34 1 Y 1 B GLU 562 ? B GLU 230 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
PHE N    N N N 264 
PHE CA   C N S 265 
PHE C    C N N 266 
PHE O    O N N 267 
PHE CB   C N N 268 
PHE CG   C Y N 269 
PHE CD1  C Y N 270 
PHE CD2  C Y N 271 
PHE CE1  C Y N 272 
PHE CE2  C Y N 273 
PHE CZ   C Y N 274 
PHE OXT  O N N 275 
PHE H    H N N 276 
PHE H2   H N N 277 
PHE HA   H N N 278 
PHE HB2  H N N 279 
PHE HB3  H N N 280 
PHE HD1  H N N 281 
PHE HD2  H N N 282 
PHE HE1  H N N 283 
PHE HE2  H N N 284 
PHE HZ   H N N 285 
PHE HXT  H N N 286 
PRO N    N N N 287 
PRO CA   C N S 288 
PRO C    C N N 289 
PRO O    O N N 290 
PRO CB   C N N 291 
PRO CG   C N N 292 
PRO CD   C N N 293 
PRO OXT  O N N 294 
PRO H    H N N 295 
PRO HA   H N N 296 
PRO HB2  H N N 297 
PRO HB3  H N N 298 
PRO HG2  H N N 299 
PRO HG3  H N N 300 
PRO HD2  H N N 301 
PRO HD3  H N N 302 
PRO HXT  H N N 303 
SER N    N N N 304 
SER CA   C N S 305 
SER C    C N N 306 
SER O    O N N 307 
SER CB   C N N 308 
SER OG   O N N 309 
SER OXT  O N N 310 
SER H    H N N 311 
SER H2   H N N 312 
SER HA   H N N 313 
SER HB2  H N N 314 
SER HB3  H N N 315 
SER HG   H N N 316 
SER HXT  H N N 317 
THR N    N N N 318 
THR CA   C N S 319 
THR C    C N N 320 
THR O    O N N 321 
THR CB   C N R 322 
THR OG1  O N N 323 
THR CG2  C N N 324 
THR OXT  O N N 325 
THR H    H N N 326 
THR H2   H N N 327 
THR HA   H N N 328 
THR HB   H N N 329 
THR HG1  H N N 330 
THR HG21 H N N 331 
THR HG22 H N N 332 
THR HG23 H N N 333 
THR HXT  H N N 334 
TRP N    N N N 335 
TRP CA   C N S 336 
TRP C    C N N 337 
TRP O    O N N 338 
TRP CB   C N N 339 
TRP CG   C Y N 340 
TRP CD1  C Y N 341 
TRP CD2  C Y N 342 
TRP NE1  N Y N 343 
TRP CE2  C Y N 344 
TRP CE3  C Y N 345 
TRP CZ2  C Y N 346 
TRP CZ3  C Y N 347 
TRP CH2  C Y N 348 
TRP OXT  O N N 349 
TRP H    H N N 350 
TRP H2   H N N 351 
TRP HA   H N N 352 
TRP HB2  H N N 353 
TRP HB3  H N N 354 
TRP HD1  H N N 355 
TRP HE1  H N N 356 
TRP HE3  H N N 357 
TRP HZ2  H N N 358 
TRP HZ3  H N N 359 
TRP HH2  H N N 360 
TRP HXT  H N N 361 
TYR N    N N N 362 
TYR CA   C N S 363 
TYR C    C N N 364 
TYR O    O N N 365 
TYR CB   C N N 366 
TYR CG   C Y N 367 
TYR CD1  C Y N 368 
TYR CD2  C Y N 369 
TYR CE1  C Y N 370 
TYR CE2  C Y N 371 
TYR CZ   C Y N 372 
TYR OH   O N N 373 
TYR OXT  O N N 374 
TYR H    H N N 375 
TYR H2   H N N 376 
TYR HA   H N N 377 
TYR HB2  H N N 378 
TYR HB3  H N N 379 
TYR HD1  H N N 380 
TYR HD2  H N N 381 
TYR HE1  H N N 382 
TYR HE2  H N N 383 
TYR HH   H N N 384 
TYR HXT  H N N 385 
VAL N    N N N 386 
VAL CA   C N S 387 
VAL C    C N N 388 
VAL O    O N N 389 
VAL CB   C N N 390 
VAL CG1  C N N 391 
VAL CG2  C N N 392 
VAL OXT  O N N 393 
VAL H    H N N 394 
VAL H2   H N N 395 
VAL HA   H N N 396 
VAL HB   H N N 397 
VAL HG11 H N N 398 
VAL HG12 H N N 399 
VAL HG13 H N N 400 
VAL HG21 H N N 401 
VAL HG22 H N N 402 
VAL HG23 H N N 403 
VAL HXT  H N N 404 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan 'JP21fk0108462, JP21fk0108585, JP21ae0121028, JP18ae0101046' 1 
'Japan Society for the Promotion of Science (JSPS)'        Japan 20H00451                                                     2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7jzu 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YDQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013358 
_atom_sites.fract_transf_matrix[1][2]   0.007712 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015425 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009942 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 1   ? 31.07450 -46.53021 -37.87988 1.000 59.12251 ? 1   ASP A N   1 
ATOM   2    C CA  . ASP A 1 1   ? 31.27573 -47.07398 -36.54045 1.000 63.47489 ? 1   ASP A CA  1 
ATOM   3    C C   . ASP A 1 1   ? 30.78794 -46.10423 -35.46520 1.000 56.77172 ? 1   ASP A C   1 
ATOM   4    O O   . ASP A 1 1   ? 30.17189 -45.08385 -35.77192 1.000 56.34263 ? 1   ASP A O   1 
ATOM   5    C CB  . ASP A 1 1   ? 32.75221 -47.41092 -36.31852 1.000 67.28582 ? 1   ASP A CB  1 
ATOM   6    C CG  . ASP A 1 1   ? 33.67589 -46.27669 -36.71765 1.000 64.08749 ? 1   ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 1   ? 33.17089 -45.22758 -37.17064 1.000 61.45638 ? 1   ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 1   ? 34.90769 -46.43632 -36.58050 1.000 69.11181 ? 1   ASP A OD2 1 
ATOM   9    N N   . LYS A 1 2   ? 31.06607 -46.43198 -34.20078 1.000 59.20102 ? 2   LYS A N   1 
ATOM   10   C CA  . LYS A 1 2   ? 30.63203 -45.56977 -33.10630 1.000 54.30341 ? 2   LYS A CA  1 
ATOM   11   C C   . LYS A 1 2   ? 31.29466 -44.20008 -33.17444 1.000 50.38812 ? 2   LYS A C   1 
ATOM   12   O O   . LYS A 1 2   ? 30.67246 -43.19130 -32.82352 1.000 50.57976 ? 2   LYS A O   1 
ATOM   13   C CB  . LYS A 1 2   ? 30.92299 -46.23823 -31.76227 1.000 52.35433 ? 2   LYS A CB  1 
ATOM   14   C CG  . LYS A 1 2   ? 30.38992 -45.47687 -30.56134 1.000 57.61553 ? 2   LYS A CG  1 
ATOM   15   C CD  . LYS A 1 2   ? 30.64899 -46.23028 -29.26196 1.000 59.55714 ? 2   LYS A CD  1 
ATOM   16   C CE  . LYS A 1 2   ? 30.18993 -45.43028 -28.05317 1.000 61.83667 ? 2   LYS A CE  1 
ATOM   17   N NZ  . LYS A 1 2   ? 30.85315 -44.09598 -27.99177 1.000 60.93004 ? 2   LYS A NZ  1 
ATOM   18   N N   . GLU A 1 3   ? 32.54326 -44.13781 -33.63783 1.000 51.93659 ? 3   GLU A N   1 
ATOM   19   C CA  . GLU A 1 3   ? 33.24465 -42.85983 -33.68147 1.000 50.86585 ? 3   GLU A CA  1 
ATOM   20   C C   . GLU A 1 3   ? 32.69654 -41.96357 -34.78333 1.000 48.90579 ? 3   GLU A C   1 
ATOM   21   O O   . GLU A 1 3   ? 32.60637 -40.74190 -34.61006 1.000 44.16822 ? 3   GLU A O   1 
ATOM   22   C CB  . GLU A 1 3   ? 34.74391 -43.09640 -33.86181 1.000 55.03081 ? 3   GLU A CB  1 
ATOM   23   C CG  . GLU A 1 3   ? 35.37450 -43.85555 -32.70049 1.000 58.44667 ? 3   GLU A CG  1 
ATOM   24   C CD  . GLU A 1 3   ? 36.82708 -44.21773 -32.94331 1.000 63.39823 ? 3   GLU A CD  1 
ATOM   25   O OE1 . GLU A 1 3   ? 37.50394 -43.50743 -33.71907 1.000 62.09273 ? 3   GLU A OE1 1 
ATOM   26   O OE2 . GLU A 1 3   ? 37.28872 -45.21977 -32.35666 1.000 63.55891 ? 3   GLU A OE2 1 
ATOM   27   N N   . TRP A 1 4   ? 32.32073 -42.54942 -35.92165 1.000 49.41668 ? 4   TRP A N   1 
ATOM   28   C CA  . TRP A 1 4   ? 31.77910 -41.75190 -37.01740 1.000 50.70874 ? 4   TRP A CA  1 
ATOM   29   C C   . TRP A 1 4   ? 30.45267 -41.11185 -36.62605 1.000 40.96783 ? 4   TRP A C   1 
ATOM   30   O O   . TRP A 1 4   ? 30.23750 -39.91482 -36.85161 1.000 43.44596 ? 4   TRP A O   1 
ATOM   31   C CB  . TRP A 1 4   ? 31.61313 -42.61913 -38.26859 1.000 51.18465 ? 4   TRP A CB  1 
ATOM   32   C CG  . TRP A 1 4   ? 30.99497 -41.89468 -39.42687 1.000 50.61626 ? 4   TRP A CG  1 
ATOM   33   C CD1 . TRP A 1 4   ? 31.64713 -41.18299 -40.39100 1.000 51.00662 ? 4   TRP A CD1 1 
ATOM   34   C CD2 . TRP A 1 4   ? 29.59871 -41.81096 -39.74238 1.000 52.59119 ? 4   TRP A CD2 1 
ATOM   35   N NE1 . TRP A 1 4   ? 30.74443 -40.66129 -41.28778 1.000 49.43949 ? 4   TRP A NE1 1 
ATOM   36   C CE2 . TRP A 1 4   ? 29.48047 -41.03297 -40.91166 1.000 52.09934 ? 4   TRP A CE2 1 
ATOM   37   C CE3 . TRP A 1 4   ? 28.43772 -42.31979 -39.15054 1.000 55.00334 ? 4   TRP A CE3 1 
ATOM   38   C CZ2 . TRP A 1 4   ? 28.24823 -40.75051 -41.49972 1.000 53.19871 ? 4   TRP A CZ2 1 
ATOM   39   C CZ3 . TRP A 1 4   ? 27.21505 -42.03753 -39.73578 1.000 52.69293 ? 4   TRP A CZ3 1 
ATOM   40   C CH2 . TRP A 1 4   ? 27.13082 -41.25956 -40.89718 1.000 51.73240 ? 4   TRP A CH2 1 
ATOM   41   N N   . ILE A 1 5   ? 29.54915 -41.89507 -36.03707 1.000 41.23732 ? 5   ILE A N   1 
ATOM   42   C CA  . ILE A 1 5   ? 28.23149 -41.36536 -35.70619 1.000 44.63210 ? 5   ILE A CA  1 
ATOM   43   C C   . ILE A 1 5   ? 28.33849 -40.32421 -34.59657 1.000 41.26693 ? 5   ILE A C   1 
ATOM   44   O O   . ILE A 1 5   ? 27.63787 -39.30530 -34.61848 1.000 40.55972 ? 5   ILE A O   1 
ATOM   45   C CB  . ILE A 1 5   ? 27.26418 -42.51047 -35.34490 1.000 50.79510 ? 5   ILE A CB  1 
ATOM   46   C CG1 . ILE A 1 5   ? 25.88928 -41.95630 -34.96726 1.000 53.83894 ? 5   ILE A CG1 1 
ATOM   47   C CG2 . ILE A 1 5   ? 27.82395 -43.37461 -34.22852 1.000 46.48214 ? 5   ILE A CG2 1 
ATOM   48   C CD1 . ILE A 1 5   ? 25.21571 -41.17603 -36.07032 1.000 54.52664 ? 5   ILE A CD1 1 
ATOM   49   N N   . LEU A 1 6   ? 29.23138 -40.54447 -33.62543 1.000 42.12744 ? 6   LEU A N   1 
ATOM   50   C CA  . LEU A 1 6   ? 29.48356 -39.51768 -32.61572 1.000 41.64302 ? 6   LEU A CA  1 
ATOM   51   C C   . LEU A 1 6   ? 29.90497 -38.20941 -33.26811 1.000 38.18666 ? 6   LEU A C   1 
ATOM   52   O O   . LEU A 1 6   ? 29.37291 -37.14223 -32.93803 1.000 35.88644 ? 6   LEU A O   1 
ATOM   53   C CB  . LEU A 1 6   ? 30.55239 -39.98748 -31.62741 1.000 41.59584 ? 6   LEU A CB  1 
ATOM   54   C CG  . LEU A 1 6   ? 30.93963 -38.97141 -30.54182 1.000 45.03222 ? 6   LEU A CG  1 
ATOM   55   C CD1 . LEU A 1 6   ? 29.71525 -38.53908 -29.75354 1.000 35.65271 ? 6   LEU A CD1 1 
ATOM   56   C CD2 . LEU A 1 6   ? 32.00171 -39.53414 -29.61152 1.000 38.25036 ? 6   LEU A CD2 1 
ATOM   57   N N   . TYR A 1 7   ? 30.83931 -38.27881 -34.22264 1.000 38.78325 ? 7   TYR A N   1 
ATOM   58   C CA  . TYR A 1 7   ? 31.24120 -37.08472 -34.95814 1.000 41.11207 ? 7   TYR A CA  1 
ATOM   59   C C   . TYR A 1 7   ? 30.05147 -36.43002 -35.64775 1.000 38.24434 ? 7   TYR A C   1 
ATOM   60   O O   . TYR A 1 7   ? 29.91905 -35.20104 -35.63310 1.000 38.71472 ? 7   TYR A O   1 
ATOM   61   C CB  . TYR A 1 7   ? 32.32489 -37.43186 -35.97945 1.000 39.61146 ? 7   TYR A CB  1 
ATOM   62   C CG  . TYR A 1 7   ? 32.69847 -36.27681 -36.88061 1.000 40.35350 ? 7   TYR A CG  1 
ATOM   63   C CD1 . TYR A 1 7   ? 33.46922 -35.22417 -36.40690 1.000 46.43704 ? 7   TYR A CD1 1 
ATOM   64   C CD2 . TYR A 1 7   ? 32.27671 -36.23594 -38.20489 1.000 44.33435 ? 7   TYR A CD2 1 
ATOM   65   C CE1 . TYR A 1 7   ? 33.81123 -34.16153 -37.22495 1.000 48.85505 ? 7   TYR A CE1 1 
ATOM   66   C CE2 . TYR A 1 7   ? 32.61350 -35.17925 -39.03058 1.000 43.42832 ? 7   TYR A CE2 1 
ATOM   67   C CZ  . TYR A 1 7   ? 33.38152 -34.14516 -38.53569 1.000 49.28766 ? 7   TYR A CZ  1 
ATOM   68   O OH  . TYR A 1 7   ? 33.72085 -33.09053 -39.35177 1.000 60.11505 ? 7   TYR A OH  1 
ATOM   69   N N   . LYS A 1 8   ? 29.16863 -37.23376 -36.25012 1.000 43.78099 ? 8   LYS A N   1 
ATOM   70   C CA  . LYS A 1 8   ? 28.03012 -36.66916 -36.97304 1.000 42.74068 ? 8   LYS A CA  1 
ATOM   71   C C   . LYS A 1 8   ? 27.02235 -36.04245 -36.01652 1.000 39.70685 ? 8   LYS A C   1 
ATOM   72   O O   . LYS A 1 8   ? 26.40634 -35.01797 -36.33600 1.000 42.39672 ? 8   LYS A O   1 
ATOM   73   C CB  . LYS A 1 8   ? 27.35724 -37.74501 -37.82583 1.000 43.44506 ? 8   LYS A CB  1 
ATOM   74   C CG  . LYS A 1 8   ? 28.26481 -38.38192 -38.87292 1.000 45.74910 ? 8   LYS A CG  1 
ATOM   75   C CD  . LYS A 1 8   ? 28.84129 -37.35656 -39.83493 1.000 46.70264 ? 8   LYS A CD  1 
ATOM   76   C CE  . LYS A 1 8   ? 27.78593 -36.81762 -40.78139 1.000 52.01560 ? 8   LYS A CE  1 
ATOM   77   N NZ  . LYS A 1 8   ? 28.37969 -35.89217 -41.78622 1.000 53.18803 ? 8   LYS A NZ  1 
ATOM   78   N N   . ILE A 1 9   ? 26.83358 -36.64605 -34.84375 1.000 38.27488 ? 9   ILE A N   1 
ATOM   79   C CA  . ILE A 1 9   ? 25.94126 -36.05542 -33.85153 1.000 36.65524 ? 9   ILE A CA  1 
ATOM   80   C C   . ILE A 1 9   ? 26.54572 -34.77333 -33.29378 1.000 40.32365 ? 9   ILE A C   1 
ATOM   81   O O   . ILE A 1 9   ? 25.85196 -33.75918 -33.14013 1.000 37.34164 ? 9   ILE A O   1 
ATOM   82   C CB  . ILE A 1 9   ? 25.62769 -37.07324 -32.74279 1.000 38.60261 ? 9   ILE A CB  1 
ATOM   83   C CG1 . ILE A 1 9   ? 24.89520 -38.28103 -33.32770 1.000 42.55215 ? 9   ILE A CG1 1 
ATOM   84   C CG2 . ILE A 1 9   ? 24.78700 -36.43252 -31.64991 1.000 36.31490 ? 9   ILE A CG2 1 
ATOM   85   C CD1 . ILE A 1 9   ? 24.66053 -39.39065 -32.33319 1.000 43.36369 ? 9   ILE A CD1 1 
ATOM   86   N N   . TYR A 1 10  ? 27.84655 -34.79197 -32.98695 1.000 37.56187 ? 10  TYR A N   1 
ATOM   87   C CA  . TYR A 1 10  ? 28.52813 -33.55842 -32.60565 1.000 38.54320 ? 10  TYR A CA  1 
ATOM   88   C C   . TYR A 1 10  ? 28.37444 -32.49825 -33.68756 1.000 38.61686 ? 10  TYR A C   1 
ATOM   89   O O   . TYR A 1 10  ? 28.03455 -31.34317 -33.40092 1.000 35.26692 ? 10  TYR A O   1 
ATOM   90   C CB  . TYR A 1 10  ? 30.00853 -33.83010 -32.32934 1.000 39.11422 ? 10  TYR A CB  1 
ATOM   91   C CG  . TYR A 1 10  ? 30.79651 -32.57008 -32.03502 1.000 42.99150 ? 10  TYR A CG  1 
ATOM   92   C CD1 . TYR A 1 10  ? 30.84535 -32.04035 -30.74862 1.000 39.32798 ? 10  TYR A CD1 1 
ATOM   93   C CD2 . TYR A 1 10  ? 31.48399 -31.90642 -33.04230 1.000 39.04233 ? 10  TYR A CD2 1 
ATOM   94   C CE1 . TYR A 1 10  ? 31.55793 -30.88442 -30.48033 1.000 39.09126 ? 10  TYR A CE1 1 
ATOM   95   C CE2 . TYR A 1 10  ? 32.19479 -30.75312 -32.78473 1.000 42.79642 ? 10  TYR A CE2 1 
ATOM   96   C CZ  . TYR A 1 10  ? 32.23127 -30.24757 -31.50254 1.000 42.51177 ? 10  TYR A CZ  1 
ATOM   97   O OH  . TYR A 1 10  ? 32.94314 -29.09780 -31.25064 1.000 44.75728 ? 10  TYR A OH  1 
ATOM   98   N N   . GLU A 1 11  ? 28.61893 -32.87999 -34.94691 1.000 36.88661 ? 11  GLU A N   1 
ATOM   99   C CA  . GLU A 1 11  ? 28.51137 -31.92835 -36.04710 1.000 39.45770 ? 11  GLU A CA  1 
ATOM   100  C C   . GLU A 1 11  ? 27.10572 -31.34573 -36.14587 1.000 36.73186 ? 11  GLU A C   1 
ATOM   101  O O   . GLU A 1 11  ? 26.94174 -30.14781 -36.40435 1.000 34.47686 ? 11  GLU A O   1 
ATOM   102  C CB  . GLU A 1 11  ? 28.90631 -32.59962 -37.36590 1.000 41.70861 ? 11  GLU A CB  1 
ATOM   103  C CG  . GLU A 1 11  ? 28.85397 -31.66685 -38.56030 1.000 46.48452 ? 11  GLU A CG  1 
ATOM   104  C CD  . GLU A 1 11  ? 29.28350 -32.32921 -39.86355 1.000 56.99451 ? 11  GLU A CD  1 
ATOM   105  O OE1 . GLU A 1 11  ? 28.96149 -33.52060 -40.08013 1.000 52.38673 ? 11  GLU A OE1 1 
ATOM   106  O OE2 . GLU A 1 11  ? 29.94754 -31.64834 -40.67417 1.000 53.48142 ? 11  GLU A OE2 1 
ATOM   107  N N   . ILE A 1 12  ? 26.07609 -32.17291 -35.94189 1.000 38.45067 ? 12  ILE A N   1 
ATOM   108  C CA  . ILE A 1 12  ? 24.71457 -31.65386 -36.04366 1.000 37.33598 ? 12  ILE A CA  1 
ATOM   109  C C   . ILE A 1 12  ? 24.38185 -30.77297 -34.84054 1.000 36.16418 ? 12  ILE A C   1 
ATOM   110  O O   . ILE A 1 12  ? 23.63748 -29.79196 -34.97092 1.000 34.41341 ? 12  ILE A O   1 
ATOM   111  C CB  . ILE A 1 12  ? 23.70073 -32.80416 -36.22452 1.000 40.85394 ? 12  ILE A CB  1 
ATOM   112  C CG1 . ILE A 1 12  ? 22.43955 -32.29588 -36.92432 1.000 48.49146 ? 12  ILE A CG1 1 
ATOM   113  C CG2 . ILE A 1 12  ? 23.30744 -33.43406 -34.90190 1.000 37.57991 ? 12  ILE A CG2 1 
ATOM   114  C CD1 . ILE A 1 12  ? 21.42334 -33.38277 -37.21111 1.000 43.26210 ? 12  ILE A CD1 1 
ATOM   115  N N   . MET A 1 13  ? 24.93543 -31.07961 -33.66425 1.000 36.88776 ? 13  MET A N   1 
ATOM   116  C CA  . MET A 1 13  ? 24.75480 -30.18695 -32.52241 1.000 32.77179 ? 13  MET A CA  1 
ATOM   117  C C   . MET A 1 13  ? 25.26080 -28.79148 -32.85244 1.000 32.21259 ? 13  MET A C   1 
ATOM   118  O O   . MET A 1 13  ? 24.54916 -27.79750 -32.66709 1.000 32.65655 ? 13  MET A O   1 
ATOM   119  C CB  . MET A 1 13  ? 25.47589 -30.73487 -31.29135 1.000 31.95202 ? 13  MET A CB  1 
ATOM   120  C CG  . MET A 1 13  ? 25.48339 -29.75177 -30.12954 1.000 36.79937 ? 13  MET A CG  1 
ATOM   121  S SD  . MET A 1 13  ? 26.37309 -30.31843 -28.66893 1.000 34.84028 ? 13  MET A SD  1 
ATOM   122  C CE  . MET A 1 13  ? 28.05754 -30.33479 -29.27369 1.000 36.81351 ? 13  MET A CE  1 
ATOM   123  N N   . VAL A 1 14  ? 26.48578 -28.70779 -33.37870 1.000 36.80667 ? 14  VAL A N   1 
ATOM   124  C CA  . VAL A 1 14  ? 27.08050 -27.41839 -33.71400 1.000 35.56125 ? 14  VAL A CA  1 
ATOM   125  C C   . VAL A 1 14  ? 26.28161 -26.72776 -34.80993 1.000 38.79410 ? 14  VAL A C   1 
ATOM   126  O O   . VAL A 1 14  ? 26.00301 -25.52449 -34.73030 1.000 36.27264 ? 14  VAL A O   1 
ATOM   127  C CB  . VAL A 1 14  ? 28.55362 -27.60816 -34.12047 1.000 37.64983 ? 14  VAL A CB  1 
ATOM   128  C CG1 . VAL A 1 14  ? 29.16386 -26.28192 -34.54575 1.000 44.08005 ? 14  VAL A CG1 1 
ATOM   129  C CG2 . VAL A 1 14  ? 29.34137 -28.22961 -32.97309 1.000 42.70117 ? 14  VAL A CG2 1 
ATOM   130  N N   . ARG A 1 15  ? 25.89508 -27.47504 -35.84862 1.000 37.70885 ? 15  ARG A N   1 
ATOM   131  C CA  . ARG A 1 15  ? 25.16584 -26.86475 -36.95527 1.000 36.23780 ? 15  ARG A CA  1 
ATOM   132  C C   . ARG A 1 15  ? 23.83228 -26.29359 -36.49051 1.000 36.83757 ? 15  ARG A C   1 
ATOM   133  O O   . ARG A 1 15  ? 23.46209 -25.17520 -36.87144 1.000 37.46273 ? 15  ARG A O   1 
ATOM   134  C CB  . ARG A 1 15  ? 24.95177 -27.88294 -38.07774 1.000 39.39257 ? 15  ARG A CB  1 
ATOM   135  C CG  . ARG A 1 15  ? 24.28634 -27.28897 -39.30611 1.000 45.43997 ? 15  ARG A CG  1 
ATOM   136  C CD  . ARG A 1 15  ? 24.08872 -28.32038 -40.40615 1.000 46.45690 ? 15  ARG A CD  1 
ATOM   137  N NE  . ARG A 1 15  ? 23.44908 -27.73495 -41.57908 1.000 50.81851 ? 15  ARG A NE  1 
ATOM   138  C CZ  . ARG A 1 15  ? 23.13128 -28.40978 -42.67536 1.000 56.29075 ? 15  ARG A CZ  1 
ATOM   139  N NH1 . ARG A 1 15  ? 23.37669 -29.70524 -42.78481 1.000 56.90247 ? 15  ARG A NH1 1 
ATOM   140  N NH2 . ARG A 1 15  ? 22.55243 -27.76857 -43.68737 1.000 57.39343 ? 15  ARG A NH2 1 
ATOM   141  N N   . LEU A 1 16  ? 23.09585 -27.04962 -35.66926 1.000 37.82142 ? 16  LEU A N   1 
ATOM   142  C CA  . LEU A 1 16  ? 21.83247 -26.55141 -35.13368 1.000 36.41913 ? 16  LEU A CA  1 
ATOM   143  C C   . LEU A 1 16  ? 22.02456 -25.21560 -34.42786 1.000 42.17040 ? 16  LEU A C   1 
ATOM   144  O O   . LEU A 1 16  ? 21.23743 -24.28235 -34.62172 1.000 41.22744 ? 16  LEU A O   1 
ATOM   145  C CB  . LEU A 1 16  ? 21.22786 -27.57752 -34.17371 1.000 38.92592 ? 16  LEU A CB  1 
ATOM   146  C CG  . LEU A 1 16  ? 20.64902 -28.85353 -34.78652 1.000 39.93596 ? 16  LEU A CG  1 
ATOM   147  C CD1 . LEU A 1 16  ? 20.32142 -29.86255 -33.70041 1.000 34.68413 ? 16  LEU A CD1 1 
ATOM   148  C CD2 . LEU A 1 16  ? 19.41676 -28.52337 -35.59076 1.000 39.62418 ? 16  LEU A CD2 1 
ATOM   149  N N   . ASP A 1 17  ? 23.07309 -25.10443 -33.60902 1.000 40.07499 ? 17  ASP A N   1 
ATOM   150  C CA  . ASP A 1 17  ? 23.34394 -23.84942 -32.91508 1.000 42.00016 ? 17  ASP A CA  1 
ATOM   151  C C   . ASP A 1 17  ? 23.66571 -22.72975 -33.89894 1.000 41.49635 ? 17  ASP A C   1 
ATOM   152  O O   . ASP A 1 17  ? 23.15579 -21.61082 -33.76503 1.000 41.76871 ? 17  ASP A O   1 
ATOM   153  C CB  . ASP A 1 17  ? 24.49239 -24.04216 -31.92421 1.000 41.40463 ? 17  ASP A CB  1 
ATOM   154  C CG  . ASP A 1 17  ? 24.80696 -22.78029 -31.14080 1.000 46.80832 ? 17  ASP A CG  1 
ATOM   155  O OD1 . ASP A 1 17  ? 23.94670 -22.34643 -30.34600 1.000 48.69524 ? 17  ASP A OD1 1 
ATOM   156  O OD2 . ASP A 1 17  ? 25.91342 -22.22641 -31.31629 1.000 47.49886 ? 17  ASP A OD2 1 
ATOM   157  N N   . GLU A 1 18  ? 24.50288 -23.01178 -34.89958 1.000 42.78568 ? 18  GLU A N   1 
ATOM   158  C CA  . GLU A 1 18  ? 24.88119 -21.97187 -35.85425 1.000 43.57951 ? 18  GLU A CA  1 
ATOM   159  C C   . GLU A 1 18  ? 23.67993 -21.45362 -36.63553 1.000 40.10387 ? 18  GLU A C   1 
ATOM   160  O O   . GLU A 1 18  ? 23.62196 -20.26388 -36.96963 1.000 39.35178 ? 18  GLU A O   1 
ATOM   161  C CB  . GLU A 1 18  ? 25.95342 -22.49669 -36.81058 1.000 46.16108 ? 18  GLU A CB  1 
ATOM   162  C CG  . GLU A 1 18  ? 27.21977 -22.97892 -36.10925 1.000 52.22752 ? 18  GLU A CG  1 
ATOM   163  C CD  . GLU A 1 18  ? 28.49276 -22.48533 -36.77288 1.000 64.67465 ? 18  GLU A CD  1 
ATOM   164  O OE1 . GLU A 1 18  ? 28.39738 -21.71567 -37.75356 1.000 67.86287 ? 18  GLU A OE1 1 
ATOM   165  O OE2 . GLU A 1 18  ? 29.58954 -22.86496 -36.30682 1.000 60.64190 ? 18  GLU A OE2 1 
ATOM   166  N N   . GLU A 1 19  ? 22.70809 -22.31594 -36.92503 1.000 42.90328 ? 19  GLU A N   1 
ATOM   167  C CA  . GLU A 1 19  ? 21.55210 -21.92219 -37.71614 1.000 45.49288 ? 19  GLU A CA  1 
ATOM   168  C C   . GLU A 1 19  ? 20.38141 -21.45499 -36.85554 1.000 44.21690 ? 19  GLU A C   1 
ATOM   169  O O   . GLU A 1 19  ? 19.24546 -21.40936 -37.33994 1.000 46.85728 ? 19  GLU A O   1 
ATOM   170  C CB  . GLU A 1 19  ? 21.13438 -23.07177 -38.63994 1.000 45.13963 ? 19  GLU A CB  1 
ATOM   171  C CG  . GLU A 1 19  ? 22.25071 -23.50089 -39.59533 1.000 43.21649 ? 19  GLU A CG  1 
ATOM   172  C CD  . GLU A 1 19  ? 21.80462 -24.52494 -40.62691 1.000 51.01719 ? 19  GLU A CD  1 
ATOM   173  O OE1 . GLU A 1 19  ? 20.58290 -24.75648 -40.75264 1.000 49.51106 ? 19  GLU A OE1 1 
ATOM   174  O OE2 . GLU A 1 19  ? 22.68138 -25.09652 -41.31397 1.000 46.23663 ? 19  GLU A OE2 1 
ATOM   175  N N   . GLY A 1 20  ? 20.63443 -21.09933 -35.59668 1.000 45.03307 ? 20  GLY A N   1 
ATOM   176  C CA  . GLY A 1 20  ? 19.60204 -20.52944 -34.75427 1.000 44.01621 ? 20  GLY A CA  1 
ATOM   177  C C   . GLY A 1 20  ? 18.68803 -21.52151 -34.07573 1.000 42.68413 ? 20  GLY A C   1 
ATOM   178  O O   . GLY A 1 20  ? 17.61168 -21.13425 -33.60920 1.000 46.61456 ? 20  GLY A O   1 
ATOM   179  N N   . HIS A 1 21  ? 19.07835 -22.79171 -33.99995 1.000 37.40461 ? 21  HIS A N   1 
ATOM   180  C CA  . HIS A 1 21  ? 18.25245 -23.79248 -33.33715 1.000 41.51816 ? 21  HIS A CA  1 
ATOM   181  C C   . HIS A 1 21  ? 18.90002 -24.22255 -32.02654 1.000 36.62541 ? 21  HIS A C   1 
ATOM   182  O O   . HIS A 1 21  ? 19.20288 -25.40424 -31.83601 1.000 34.93973 ? 21  HIS A O   1 
ATOM   183  C CB  . HIS A 1 21  ? 18.03181 -24.99165 -34.26134 1.000 38.82730 ? 21  HIS A CB  1 
ATOM   184  C CG  . HIS A 1 21  ? 17.47039 -24.62028 -35.59871 1.000 41.34225 ? 21  HIS A CG  1 
ATOM   185  N ND1 . HIS A 1 21  ? 16.26883 -23.96025 -35.74327 1.000 41.99093 ? 21  HIS A ND1 1 
ATOM   186  C CD2 . HIS A 1 21  ? 17.94764 -24.81293 -36.85143 1.000 42.51414 ? 21  HIS A CD2 1 
ATOM   187  C CE1 . HIS A 1 21  ? 16.03033 -23.76145 -37.02776 1.000 42.50187 ? 21  HIS A CE1 1 
ATOM   188  N NE2 . HIS A 1 21  ? 17.03280 -24.27060 -37.72108 1.000 40.93373 ? 21  HIS A NE2 1 
ATOM   189  N N   . GLY A 1 22  ? 19.10412 -23.26314 -31.12038 1.000 42.43535 ? 22  GLY A N   1 
ATOM   190  C CA  . GLY A 1 22  ? 19.86279 -23.53990 -29.90872 1.000 43.08480 ? 22  GLY A CA  1 
ATOM   191  C C   . GLY A 1 22  ? 19.17694 -24.51953 -28.97509 1.000 38.88405 ? 22  GLY A C   1 
ATOM   192  O O   . GLY A 1 22  ? 19.83661 -25.33806 -28.32575 1.000 37.33156 ? 22  GLY A O   1 
ATOM   193  N N   . GLU A 1 23  ? 17.84848 -24.44680 -28.87971 1.000 39.35729 ? 23  GLU A N   1 
ATOM   194  C CA  . GLU A 1 23  ? 17.13186 -25.38716 -28.02571 1.000 38.26273 ? 23  GLU A CA  1 
ATOM   195  C C   . GLU A 1 23  ? 17.25504 -26.80796 -28.55434 1.000 35.14636 ? 23  GLU A C   1 
ATOM   196  O O   . GLU A 1 23  ? 17.44801 -27.75342 -27.78244 1.000 33.17202 ? 23  GLU A O   1 
ATOM   197  C CB  . GLU A 1 23  ? 15.66542 -24.97793 -27.90601 1.000 43.26879 ? 23  GLU A CB  1 
ATOM   198  C CG  . GLU A 1 23  ? 15.26113 -24.65777 -26.49110 1.000 49.20976 ? 23  GLU A CG  1 
ATOM   199  C CD  . GLU A 1 23  ? 13.79155 -24.34356 -26.35629 1.000 48.07846 ? 23  GLU A CD  1 
ATOM   200  O OE1 . GLU A 1 23  ? 13.23854 -23.69677 -27.26702 1.000 47.87617 ? 23  GLU A OE1 1 
ATOM   201  O OE2 . GLU A 1 23  ? 13.19241 -24.74605 -25.33590 1.000 49.00760 ? 23  GLU A OE2 1 
ATOM   202  N N   . ALA A 1 24  ? 17.14073 -26.98046 -29.87360 1.000 36.59333 ? 24  ALA A N   1 
ATOM   203  C CA  . ALA A 1 24  ? 17.39771 -28.28599 -30.46412 1.000 32.06995 ? 24  ALA A CA  1 
ATOM   204  C C   . ALA A 1 24  ? 18.83494 -28.72459 -30.21558 1.000 29.13539 ? 24  ALA A C   1 
ATOM   205  O O   . ALA A 1 24  ? 19.10142 -29.90903 -29.98060 1.000 30.51426 ? 24  ALA A O   1 
ATOM   206  C CB  . ALA A 1 24  ? 17.10176 -28.24190 -31.96390 1.000 33.67820 ? 24  ALA A CB  1 
ATOM   207  N N   . SER A 1 25  ? 19.77810 -27.78267 -30.28276 1.000 27.71176 ? 25  SER A N   1 
ATOM   208  C CA  . SER A 1 25  ? 21.17971 -28.12904 -30.08285 1.000 33.80431 ? 25  SER A CA  1 
ATOM   209  C C   . SER A 1 25  ? 21.40938 -28.64984 -28.67206 1.000 34.50740 ? 25  SER A C   1 
ATOM   210  O O   . SER A 1 25  ? 22.16687 -29.60693 -28.46725 1.000 34.53501 ? 25  SER A O   1 
ATOM   211  C CB  . SER A 1 25  ? 22.06273 -26.91286 -30.36381 1.000 35.30105 ? 25  SER A CB  1 
ATOM   212  O OG  . SER A 1 25  ? 23.43498 -27.25271 -30.27357 1.000 36.88207 ? 25  SER A OG  1 
ATOM   213  N N   . LEU A 1 26  ? 20.74418 -28.04119 -27.68744 1.000 33.62395 ? 26  LEU A N   1 
ATOM   214  C CA  . LEU A 1 26  ? 20.85901 -28.51065 -26.31114 1.000 36.15493 ? 26  LEU A CA  1 
ATOM   215  C C   . LEU A 1 26  ? 20.31317 -29.92382 -26.15877 1.000 33.84068 ? 26  LEU A C   1 
ATOM   216  O O   . LEU A 1 26  ? 20.84707 -30.71380 -25.37250 1.000 36.29426 ? 26  LEU A O   1 
ATOM   217  C CB  . LEU A 1 26  ? 20.13091 -27.54729 -25.37215 1.000 30.86167 ? 26  LEU A CB  1 
ATOM   218  C CG  . LEU A 1 26  ? 20.75830 -26.16065 -25.18374 1.000 37.87717 ? 26  LEU A CG  1 
ATOM   219  C CD1 . LEU A 1 26  ? 19.81752 -25.21848 -24.44414 1.000 36.58638 ? 26  LEU A CD1 1 
ATOM   220  C CD2 . LEU A 1 26  ? 22.07923 -26.27312 -24.43714 1.000 36.17062 ? 26  LEU A CD2 1 
ATOM   221  N N   . MET A 1 27  ? 19.26210 -30.26699 -26.91108 1.000 36.33788 ? 27  MET A N   1 
ATOM   222  C CA  . MET A 1 27  ? 18.71966 -31.62016 -26.83495 1.000 33.16056 ? 27  MET A CA  1 
ATOM   223  C C   . MET A 1 27  ? 19.68422 -32.63349 -27.43776 1.000 33.59014 ? 27  MET A C   1 
ATOM   224  O O   . MET A 1 27  ? 19.81118 -33.75474 -26.93009 1.000 33.46767 ? 27  MET A O   1 
ATOM   225  C CB  . MET A 1 27  ? 17.36121 -31.68130 -27.53672 1.000 38.80869 ? 27  MET A CB  1 
ATOM   226  C CG  . MET A 1 27  ? 16.29043 -30.81722 -26.88368 1.000 38.09203 ? 27  MET A CG  1 
ATOM   227  S SD  . MET A 1 27  ? 14.72711 -30.80519 -27.78569 1.000 54.36583 ? 27  MET A SD  1 
ATOM   228  C CE  . MET A 1 27  ? 14.59162 -32.54226 -28.22169 1.000 42.32171 ? 27  MET A CE  1 
ATOM   229  N N   . VAL A 1 28  ? 20.36479 -32.26086 -28.52775 1.000 34.13123 ? 28  VAL A N   1 
ATOM   230  C CA  . VAL A 1 28  ? 21.38360 -33.13380 -29.10320 1.000 33.98105 ? 28  VAL A CA  1 
ATOM   231  C C   . VAL A 1 28  ? 22.56581 -33.27348 -28.14787 1.000 36.08624 ? 28  VAL A C   1 
ATOM   232  O O   . VAL A 1 28  ? 23.11325 -34.37007 -27.97253 1.000 36.19350 ? 28  VAL A O   1 
ATOM   233  C CB  . VAL A 1 28  ? 21.80869 -32.60859 -30.48872 1.000 38.48370 ? 28  VAL A CB  1 
ATOM   234  C CG1 . VAL A 1 28  ? 22.94661 -33.43908 -31.06083 1.000 33.38360 ? 28  VAL A CG1 1 
ATOM   235  C CG2 . VAL A 1 28  ? 20.61851 -32.62404 -31.43759 1.000 31.56939 ? 28  VAL A CG2 1 
ATOM   236  N N   . SER A 1 29  ? 22.96496 -32.17364 -27.50027 1.000 37.65548 ? 29  SER A N   1 
ATOM   237  C CA  . SER A 1 29  ? 23.99019 -32.25422 -26.46163 1.000 36.41109 ? 29  SER A CA  1 
ATOM   238  C C   . SER A 1 29  ? 23.64112 -33.30963 -25.41940 1.000 33.49423 ? 29  SER A C   1 
ATOM   239  O O   . SER A 1 29  ? 24.50963 -34.07608 -24.98393 1.000 36.47135 ? 29  SER A O   1 
ATOM   240  C CB  . SER A 1 29  ? 24.17410 -30.88987 -25.79349 1.000 38.29513 ? 29  SER A CB  1 
ATOM   241  O OG  . SER A 1 29  ? 25.03450 -30.98963 -24.66698 1.000 36.79878 ? 29  SER A OG  1 
ATOM   242  N N   . ASP A 1 30  ? 22.36988 -33.37138 -25.00956 1.000 33.40432 ? 30  ASP A N   1 
ATOM   243  C CA  . ASP A 1 30  ? 21.95952 -34.39898 -24.05621 1.000 35.20760 ? 30  ASP A CA  1 
ATOM   244  C C   . ASP A 1 30  ? 22.15425 -35.79453 -24.63195 1.000 36.80771 ? 30  ASP A C   1 
ATOM   245  O O   . ASP A 1 30  ? 22.56282 -36.71603 -23.91625 1.000 35.62443 ? 30  ASP A O   1 
ATOM   246  C CB  . ASP A 1 30  ? 20.50052 -34.19520 -23.64116 1.000 38.80163 ? 30  ASP A CB  1 
ATOM   247  C CG  . ASP A 1 30  ? 20.29991 -32.95019 -22.79901 1.000 41.38858 ? 30  ASP A CG  1 
ATOM   248  O OD1 . ASP A 1 30  ? 21.26353 -32.52194 -22.12938 1.000 37.48768 ? 30  ASP A OD1 1 
ATOM   249  O OD2 . ASP A 1 30  ? 19.17731 -32.39817 -22.80868 1.000 44.34076 ? 30  ASP A OD2 1 
ATOM   250  N N   . LEU A 1 31  ? 21.86606 -35.96927 -25.92580 1.000 37.97947 ? 31  LEU A N   1 
ATOM   251  C CA  . LEU A 1 31  ? 22.06845 -37.26600 -26.56292 1.000 33.90731 ? 31  LEU A CA  1 
ATOM   252  C C   . LEU A 1 31  ? 23.53725 -37.67029 -26.53602 1.000 33.01189 ? 31  LEU A C   1 
ATOM   253  O O   . LEU A 1 31  ? 23.85994 -38.84798 -26.34002 1.000 36.44603 ? 31  LEU A O   1 
ATOM   254  C CB  . LEU A 1 31  ? 21.54637 -37.22693 -28.00454 1.000 34.54169 ? 31  LEU A CB  1 
ATOM   255  C CG  . LEU A 1 31  ? 21.82000 -38.45209 -28.87950 1.000 37.26027 ? 31  LEU A CG  1 
ATOM   256  C CD1 . LEU A 1 31  ? 21.26157 -39.71453 -28.24468 1.000 40.81866 ? 31  LEU A CD1 1 
ATOM   257  C CD2 . LEU A 1 31  ? 21.24873 -38.25637 -30.28550 1.000 41.14625 ? 31  LEU A CD2 1 
ATOM   258  N N   . ILE A 1 32  ? 24.44173 -36.70743 -26.73570 1.000 32.44531 ? 32  ILE A N   1 
ATOM   259  C CA  . ILE A 1 32  ? 25.87017 -37.01557 -26.74284 1.000 33.95704 ? 32  ILE A CA  1 
ATOM   260  C C   . ILE A 1 32  ? 26.29969 -37.57265 -25.39500 1.000 39.66601 ? 32  ILE A C   1 
ATOM   261  O O   . ILE A 1 32  ? 27.02116 -38.57734 -25.32134 1.000 37.45203 ? 32  ILE A O   1 
ATOM   262  C CB  . ILE A 1 32  ? 26.68462 -35.76660 -27.13000 1.000 38.09442 ? 32  ILE A CB  1 
ATOM   263  C CG1 . ILE A 1 32  ? 26.50053 -35.45409 -28.61365 1.000 39.19274 ? 32  ILE A CG1 1 
ATOM   264  C CG2 . ILE A 1 32  ? 28.16379 -35.96850 -26.82173 1.000 38.26165 ? 32  ILE A CG2 1 
ATOM   265  C CD1 . ILE A 1 32  ? 27.13131 -34.14507 -29.04399 1.000 36.69125 ? 32  ILE A CD1 1 
ATOM   266  N N   . TYR A 1 33  ? 25.84576 -36.94369 -24.30717 1.000 36.38194 ? 33  TYR A N   1 
ATOM   267  C CA  . TYR A 1 33  ? 26.15888 -37.44545 -22.97534 1.000 39.02024 ? 33  TYR A CA  1 
ATOM   268  C C   . TYR A 1 33  ? 25.69264 -38.88650 -22.80317 1.000 40.90215 ? 33  TYR A C   1 
ATOM   269  O O   . TYR A 1 33  ? 26.45760 -39.74925 -22.35691 1.000 40.14844 ? 33  TYR A O   1 
ATOM   270  C CB  . TYR A 1 33  ? 25.52417 -36.55387 -21.90712 1.000 36.35409 ? 33  TYR A CB  1 
ATOM   271  C CG  . TYR A 1 33  ? 25.51586 -37.22091 -20.55295 1.000 40.64765 ? 33  TYR A CG  1 
ATOM   272  C CD1 . TYR A 1 33  ? 26.64895 -37.21629 -19.75203 1.000 39.49717 ? 33  TYR A CD1 1 
ATOM   273  C CD2 . TYR A 1 33  ? 24.38413 -37.87882 -20.08477 1.000 38.80619 ? 33  TYR A CD2 1 
ATOM   274  C CE1 . TYR A 1 33  ? 26.65521 -37.84003 -18.52908 1.000 40.89292 ? 33  TYR A CE1 1 
ATOM   275  C CE2 . TYR A 1 33  ? 24.38269 -38.50433 -18.85836 1.000 40.72277 ? 33  TYR A CE2 1 
ATOM   276  C CZ  . TYR A 1 33  ? 25.51993 -38.48076 -18.08419 1.000 40.85259 ? 33  TYR A CZ  1 
ATOM   277  O OH  . TYR A 1 33  ? 25.52402 -39.10184 -16.85814 1.000 40.76621 ? 33  TYR A OH  1 
ATOM   278  N N   . GLU A 1 34  ? 24.42993 -39.16391 -23.13645 1.000 41.80058 ? 34  GLU A N   1 
ATOM   279  C CA  . GLU A 1 34  ? 23.90414 -40.51043 -22.93295 1.000 44.79142 ? 34  GLU A CA  1 
ATOM   280  C C   . GLU A 1 34  ? 24.61379 -41.52050 -23.82511 1.000 44.09687 ? 34  GLU A C   1 
ATOM   281  O O   . GLU A 1 34  ? 24.88548 -42.65047 -23.40088 1.000 46.44777 ? 34  GLU A O   1 
ATOM   282  C CB  . GLU A 1 34  ? 22.39621 -40.53880 -23.18648 1.000 44.87334 ? 34  GLU A CB  1 
ATOM   283  C CG  . GLU A 1 34  ? 21.73391 -41.82610 -22.70377 1.000 52.47261 ? 34  GLU A CG  1 
ATOM   284  C CD  . GLU A 1 34  ? 20.24150 -41.87648 -22.98226 1.000 59.21236 ? 34  GLU A CD  1 
ATOM   285  O OE1 . GLU A 1 34  ? 19.71200 -40.93891 -23.61840 1.000 60.35756 ? 34  GLU A OE1 1 
ATOM   286  O OE2 . GLU A 1 34  ? 19.59843 -42.86295 -22.56141 1.000 61.76672 ? 34  GLU A OE2 1 
ATOM   287  N N   . PHE A 1 35  ? 24.93000 -41.12531 -25.05914 1.000 46.08584 ? 35  PHE A N   1 
ATOM   288  C CA  . PHE A 1 35  ? 25.57994 -42.03333 -25.99872 1.000 49.03021 ? 35  PHE A CA  1 
ATOM   289  C C   . PHE A 1 35  ? 26.94932 -42.46703 -25.48912 1.000 46.53133 ? 35  PHE A C   1 
ATOM   290  O O   . PHE A 1 35  ? 27.28309 -43.65763 -25.50247 1.000 50.74848 ? 35  PHE A O   1 
ATOM   291  C CB  . PHE A 1 35  ? 25.70164 -41.35445 -27.36184 1.000 46.64330 ? 35  PHE A CB  1 
ATOM   292  C CG  . PHE A 1 35  ? 26.21567 -42.25106 -28.45175 1.000 50.34064 ? 35  PHE A CG  1 
ATOM   293  C CD1 . PHE A 1 35  ? 26.03460 -43.62345 -28.39191 1.000 56.06155 ? 35  PHE A CD1 1 
ATOM   294  C CD2 . PHE A 1 35  ? 26.88063 -41.71525 -29.54082 1.000 52.03052 ? 35  PHE A CD2 1 
ATOM   295  C CE1 . PHE A 1 35  ? 26.50747 -44.44385 -29.40288 1.000 56.50611 ? 35  PHE A CE1 1 
ATOM   296  C CE2 . PHE A 1 35  ? 27.35766 -42.52950 -30.55335 1.000 51.91951 ? 35  PHE A CE2 1 
ATOM   297  C CZ  . PHE A 1 35  ? 27.17138 -43.89642 -30.48283 1.000 55.14808 ? 35  PHE A CZ  1 
ATOM   298  N N   . MET A 1 36  ? 27.76161 -41.51042 -25.03965 1.000 43.79351 ? 36  MET A N   1 
ATOM   299  C CA  . MET A 1 36  ? 29.10545 -41.84516 -24.58722 1.000 48.46723 ? 36  MET A CA  1 
ATOM   300  C C   . MET A 1 36  ? 29.10040 -42.55203 -23.23968 1.000 50.29792 ? 36  MET A C   1 
ATOM   301  O O   . MET A 1 36  ? 30.10464 -43.17204 -22.87388 1.000 52.54379 ? 36  MET A O   1 
ATOM   302  C CB  . MET A 1 36  ? 29.96167 -40.58166 -24.53152 1.000 43.85010 ? 36  MET A CB  1 
ATOM   303  C CG  . MET A 1 36  ? 30.00196 -39.84389 -25.85807 1.000 43.64087 ? 36  MET A CG  1 
ATOM   304  S SD  . MET A 1 36  ? 31.08426 -38.41157 -25.85925 1.000 45.03515 ? 36  MET A SD  1 
ATOM   305  C CE  . MET A 1 36  ? 32.68800 -39.21114 -25.80117 1.000 45.82495 ? 36  MET A CE  1 
ATOM   306  N N   . LYS A 1 37  ? 27.99517 -42.48320 -22.50084 1.000 48.00134 ? 37  LYS A N   1 
ATOM   307  C CA  . LYS A 1 37  ? 27.86840 -43.23624 -21.26210 1.000 48.98899 ? 37  LYS A CA  1 
ATOM   308  C C   . LYS A 1 37  ? 27.51339 -44.69885 -21.49092 1.000 55.95165 ? 37  LYS A C   1 
ATOM   309  O O   . LYS A 1 37  ? 27.55477 -45.48516 -20.53873 1.000 54.50372 ? 37  LYS A O   1 
ATOM   310  C CB  . LYS A 1 37  ? 26.81636 -42.58811 -20.36044 1.000 48.94972 ? 37  LYS A CB  1 
ATOM   311  C CG  . LYS A 1 37  ? 27.34106 -41.42488 -19.54619 1.000 43.97979 ? 37  LYS A CG  1 
ATOM   312  C CD  . LYS A 1 37  ? 28.43231 -41.89185 -18.59999 1.000 52.18305 ? 37  LYS A CD  1 
ATOM   313  C CE  . LYS A 1 37  ? 28.72635 -40.85078 -17.53844 1.000 45.87036 ? 37  LYS A CE  1 
ATOM   314  N NZ  . LYS A 1 37  ? 29.85632 -41.25871 -16.66639 1.000 44.67742 ? 37  LYS A NZ  1 
ATOM   315  N N   . ARG A 1 38  ? 27.17007 -45.08444 -22.71531 1.000 54.30990 ? 38  ARG A N   1 
ATOM   316  C CA  . ARG A 1 38  ? 26.78485 -46.45734 -22.99731 1.000 60.66691 ? 38  ARG A CA  1 
ATOM   317  C C   . ARG A 1 38  ? 28.01705 -47.31316 -23.26650 1.000 68.07631 ? 38  ARG A C   1 
ATOM   318  O O   . ARG A 1 38  ? 29.04026 -46.82891 -23.75906 1.000 68.22345 ? 38  ARG A O   1 
ATOM   319  C CB  . ARG A 1 38  ? 25.82979 -46.51784 -24.19140 1.000 63.96552 ? 38  ARG A CB  1 
ATOM   320  C CG  . ARG A 1 38  ? 25.00974 -47.79245 -24.24898 1.000 63.14453 ? 38  ARG A CG  1 
ATOM   321  C CD  . ARG A 1 38  ? 23.76608 -47.60636 -25.08863 1.000 61.03890 ? 38  ARG A CD  1 
ATOM   322  N NE  . ARG A 1 38  ? 22.82908 -48.71373 -24.93631 1.000 57.86976 ? 38  ARG A NE  1 
ATOM   323  C CZ  . ARG A 1 38  ? 21.91069 -48.79214 -23.98212 1.000 62.00551 ? 38  ARG A CZ  1 
ATOM   324  N NH1 . ARG A 1 38  ? 21.78667 -47.84850 -23.06229 1.000 60.63612 ? 38  ARG A NH1 1 
ATOM   325  N NH2 . ARG A 1 38  ? 21.09704 -49.84480 -23.94886 1.000 59.93522 ? 38  ARG A NH2 1 
ATOM   326  N N   . ASP A 1 39  ? 27.90772 -48.59620 -22.92963 1.000 74.42890 ? 39  ASP A N   1 
ATOM   327  C CA  . ASP A 1 39  ? 28.99653 -49.54938 -23.12587 1.000 76.05008 ? 39  ASP A CA  1 
ATOM   328  C C   . ASP A 1 39  ? 29.22624 -49.83696 -24.60746 1.000 78.87809 ? 39  ASP A C   1 
ATOM   329  O O   . ASP A 1 39  ? 30.36085 -49.82046 -25.08914 1.000 80.22926 ? 39  ASP A O   1 
ATOM   330  C CB  . ASP A 1 39  ? 28.70502 -50.85551 -22.38215 1.000 77.14022 ? 39  ASP A CB  1 
ATOM   331  C CG  . ASP A 1 39  ? 28.49850 -50.64740 -20.89221 1.000 85.26639 ? 39  ASP A CG  1 
ATOM   332  O OD1 . ASP A 1 39  ? 29.12318 -49.72548 -20.32422 1.000 84.29222 ? 39  ASP A OD1 1 
ATOM   333  O OD2 . ASP A 1 39  ? 27.71133 -51.40796 -20.28825 1.000 86.03741 ? 39  ASP A OD2 1 
ATOM   334  O OXT . ASP A 1 39  ? 28.28267 -50.09139 -25.35866 1.000 79.97654 ? 39  ASP A OXT 1 
ATOM   335  N N   . THR B 2 1   ? 30.09138 -9.10377  15.58743  1.000 76.75850 ? 333 THR B N   1 
ATOM   336  C CA  . THR B 2 1   ? 30.27499 -9.47999  14.19080  1.000 76.78691 ? 333 THR B CA  1 
ATOM   337  C C   . THR B 2 1   ? 29.20723 -8.84381  13.30208  1.000 76.34078 ? 333 THR B C   1 
ATOM   338  O O   . THR B 2 1   ? 28.17321 -8.38064  13.78701  1.000 78.63206 ? 333 THR B O   1 
ATOM   339  C CB  . THR B 2 1   ? 30.24842 -11.01186 14.01139  1.000 69.82865 ? 333 THR B CB  1 
ATOM   340  O OG1 . THR B 2 1   ? 29.15718 -11.56667 14.75737  1.000 72.95509 ? 333 THR B OG1 1 
ATOM   341  C CG2 . THR B 2 1   ? 31.55549 -11.62926 14.49150  1.000 69.39202 ? 333 THR B CG2 1 
ATOM   342  N N   . ASN B 2 2   ? 29.46772 -8.82353  11.99744  1.000 76.21927 ? 334 ASN B N   1 
ATOM   343  C CA  . ASN B 2 2   ? 28.57067 -8.19602  11.04205  1.000 73.87284 ? 334 ASN B CA  1 
ATOM   344  C C   . ASN B 2 2   ? 27.52383 -9.19818  10.55681  1.000 66.79501 ? 334 ASN B C   1 
ATOM   345  O O   . ASN B 2 2   ? 27.44440 -10.33627 11.02588  1.000 59.53843 ? 334 ASN B O   1 
ATOM   346  C CB  . ASN B 2 2   ? 29.36360 -7.61975  9.86890   1.000 73.00276 ? 334 ASN B CB  1 
ATOM   347  C CG  . ASN B 2 2   ? 30.47696 -6.69052  10.31627  1.000 75.52149 ? 334 ASN B CG  1 
ATOM   348  O OD1 . ASN B 2 2   ? 30.45255 -6.16484  11.43003  1.000 80.88263 ? 334 ASN B OD1 1 
ATOM   349  N ND2 . ASN B 2 2   ? 31.45962 -6.48033  9.44584   1.000 67.58898 ? 334 ASN B ND2 1 
ATOM   350  N N   . LEU B 2 3   ? 26.69982 -8.76388  9.60681   1.000 72.33544 ? 335 LEU B N   1 
ATOM   351  C CA  . LEU B 2 3   ? 25.73646 -9.65448  8.97731   1.000 66.97858 ? 335 LEU B CA  1 
ATOM   352  C C   . LEU B 2 3   ? 26.41024 -10.44186 7.86139   1.000 64.12779 ? 335 LEU B C   1 
ATOM   353  O O   . LEU B 2 3   ? 27.28030 -9.92418  7.15411   1.000 64.48195 ? 335 LEU B O   1 
ATOM   354  C CB  . LEU B 2 3   ? 24.54753 -8.86499  8.42496   1.000 72.24949 ? 335 LEU B CB  1 
ATOM   355  C CG  . LEU B 2 3   ? 23.20139 -9.04594  9.13761   1.000 74.15613 ? 335 LEU B CG  1 
ATOM   356  C CD1 . LEU B 2 3   ? 23.27174 -8.58798  10.59043  1.000 63.67258 ? 335 LEU B CD1 1 
ATOM   357  C CD2 . LEU B 2 3   ? 22.08799 -8.31718  8.39277   1.000 76.36187 ? 335 LEU B CD2 1 
ATOM   358  N N   . CYS B 2 4   ? 26.00960 -11.69897 7.71304   1.000 62.48249 ? 336 CYS B N   1 
ATOM   359  C CA  . CYS B 2 4   ? 26.61783 -12.55704 6.70244   1.000 62.21611 ? 336 CYS B CA  1 
ATOM   360  C C   . CYS B 2 4   ? 26.25090 -12.05950 5.30874   1.000 60.98607 ? 336 CYS B C   1 
ATOM   361  O O   . CYS B 2 4   ? 25.07893 -11.75884 5.05081   1.000 57.97763 ? 336 CYS B O   1 
ATOM   362  C CB  . CYS B 2 4   ? 26.17364 -14.00534 6.89077   1.000 61.21361 ? 336 CYS B CB  1 
ATOM   363  S SG  . CYS B 2 4   ? 26.70182 -14.72992 8.46740   1.000 56.86078 ? 336 CYS B SG  1 
ATOM   364  N N   . PRO B 2 5   ? 27.21224 -11.95716 4.38961   1.000 59.85459 ? 337 PRO B N   1 
ATOM   365  C CA  . PRO B 2 5   ? 26.95004 -11.36258 3.06663   1.000 62.67139 ? 337 PRO B CA  1 
ATOM   366  C C   . PRO B 2 5   ? 26.30463 -12.34562 2.09437   1.000 59.96956 ? 337 PRO B C   1 
ATOM   367  O O   . PRO B 2 5   ? 26.82177 -12.62079 1.00814   1.000 63.20584 ? 337 PRO B O   1 
ATOM   368  C CB  . PRO B 2 5   ? 28.35366 -10.93354 2.62261   1.000 58.77936 ? 337 PRO B CB  1 
ATOM   369  C CG  . PRO B 2 5   ? 29.24445 -11.97601 3.22142   1.000 62.41817 ? 337 PRO B CG  1 
ATOM   370  C CD  . PRO B 2 5   ? 28.62531 -12.34544 4.55154   1.000 58.56235 ? 337 PRO B CD  1 
ATOM   371  N N   . PHE B 2 6   ? 25.14944 -12.88791 2.48626   1.000 57.68744 ? 338 PHE B N   1 
ATOM   372  C CA  . PHE B 2 6   ? 24.40357 -13.74698 1.57484   1.000 56.90134 ? 338 PHE B CA  1 
ATOM   373  C C   . PHE B 2 6   ? 23.80941 -12.96631 0.41175   1.000 60.75950 ? 338 PHE B C   1 
ATOM   374  O O   . PHE B 2 6   ? 23.55235 -13.55399 -0.64365  1.000 57.16268 ? 338 PHE B O   1 
ATOM   375  C CB  . PHE B 2 6   ? 23.29756 -14.49290 2.32183   1.000 60.20138 ? 338 PHE B CB  1 
ATOM   376  C CG  . PHE B 2 6   ? 23.79230 -15.66232 3.12951   1.000 60.90272 ? 338 PHE B CG  1 
ATOM   377  C CD1 . PHE B 2 6   ? 24.40879 -16.73758 2.50750   1.000 52.57326 ? 338 PHE B CD1 1 
ATOM   378  C CD2 . PHE B 2 6   ? 23.63088 -15.69247 4.50391   1.000 58.65858 ? 338 PHE B CD2 1 
ATOM   379  C CE1 . PHE B 2 6   ? 24.86217 -17.81634 3.24075   1.000 48.61057 ? 338 PHE B CE1 1 
ATOM   380  C CE2 . PHE B 2 6   ? 24.08182 -16.76910 5.24496   1.000 58.90762 ? 338 PHE B CE2 1 
ATOM   381  C CZ  . PHE B 2 6   ? 24.69658 -17.83251 4.61542   1.000 56.87015 ? 338 PHE B CZ  1 
ATOM   382  N N   . ASP B 2 7   ? 23.58563 -11.66028 0.58227   1.000 63.32815 ? 339 ASP B N   1 
ATOM   383  C CA  . ASP B 2 7   ? 23.13115 -10.83561 -0.53115  1.000 58.10795 ? 339 ASP B CA  1 
ATOM   384  C C   . ASP B 2 7   ? 24.18562 -10.75808 -1.62682  1.000 62.22850 ? 339 ASP B C   1 
ATOM   385  O O   . ASP B 2 7   ? 23.84491 -10.66942 -2.81209  1.000 61.80274 ? 339 ASP B O   1 
ATOM   386  C CB  . ASP B 2 7   ? 22.76504 -9.43602  -0.02854  1.000 63.97746 ? 339 ASP B CB  1 
ATOM   387  C CG  . ASP B 2 7   ? 22.24374 -8.52832  -1.13370  1.000 76.54698 ? 339 ASP B CG  1 
ATOM   388  O OD1 . ASP B 2 7   ? 23.05019 -8.06599  -1.97046  1.000 78.00796 ? 339 ASP B OD1 1 
ATOM   389  O OD2 . ASP B 2 7   ? 21.01994 -8.27930  -1.16834  1.000 83.06174 ? 339 ASP B OD2 1 
ATOM   390  N N   . GLU B 2 8   ? 25.46643 -10.79885 -1.25355  1.000 59.36142 ? 340 GLU B N   1 
ATOM   391  C CA  . GLU B 2 8   ? 26.53389 -10.77747 -2.24815  1.000 61.80533 ? 340 GLU B CA  1 
ATOM   392  C C   . GLU B 2 8   ? 26.50568 -12.02316 -3.12870  1.000 62.64174 ? 340 GLU B C   1 
ATOM   393  O O   . GLU B 2 8   ? 26.95007 -11.97840 -4.28238  1.000 54.13331 ? 340 GLU B O   1 
ATOM   394  C CB  . GLU B 2 8   ? 27.88611 -10.64181 -1.54523  1.000 68.09815 ? 340 GLU B CB  1 
ATOM   395  C CG  . GLU B 2 8   ? 29.07206 -10.39483 -2.46333  1.000 72.67324 ? 340 GLU B CG  1 
ATOM   396  C CD  . GLU B 2 8   ? 30.37003 -10.20533 -1.69519  1.000 75.71767 ? 340 GLU B CD  1 
ATOM   397  O OE1 . GLU B 2 8   ? 30.34884 -10.31595 -0.44961  1.000 72.14915 ? 340 GLU B OE1 1 
ATOM   398  O OE2 . GLU B 2 8   ? 31.41012 -9.94417  -2.33701  1.000 76.84434 ? 340 GLU B OE2 1 
ATOM   399  N N   . VAL B 2 9   ? 25.97935 -13.12953 -2.61096  1.000 58.43190 ? 341 VAL B N   1 
ATOM   400  C CA  . VAL B 2 9   ? 25.91276 -14.38392 -3.35480  1.000 57.92835 ? 341 VAL B CA  1 
ATOM   401  C C   . VAL B 2 9   ? 24.61219 -14.49687 -4.13888  1.000 54.04320 ? 341 VAL B C   1 
ATOM   402  O O   . VAL B 2 9   ? 24.62157 -14.75500 -5.34581  1.000 52.59778 ? 341 VAL B O   1 
ATOM   403  C CB  . VAL B 2 9   ? 26.09038 -15.57225 -2.38545  1.000 54.14015 ? 341 VAL B CB  1 
ATOM   404  C CG1 . VAL B 2 9   ? 25.89024 -16.89022 -3.11517  1.000 53.34001 ? 341 VAL B CG1 1 
ATOM   405  C CG2 . VAL B 2 9   ? 27.46198 -15.51934 -1.72707  1.000 55.61119 ? 341 VAL B CG2 1 
ATOM   406  N N   . PHE B 2 10  ? 23.47679 -14.29806 -3.46559  1.000 51.69340 ? 342 PHE B N   1 
ATOM   407  C CA  . PHE B 2 10  ? 22.18254 -14.47915 -4.11632  1.000 51.00676 ? 342 PHE B CA  1 
ATOM   408  C C   . PHE B 2 10  ? 21.89528 -13.37370 -5.12604  1.000 57.33104 ? 342 PHE B C   1 
ATOM   409  O O   . PHE B 2 10  ? 21.32534 -13.63618 -6.19143  1.000 52.69769 ? 342 PHE B O   1 
ATOM   410  C CB  . PHE B 2 10  ? 21.07325 -14.54305 -3.06570  1.000 51.09096 ? 342 PHE B CB  1 
ATOM   411  C CG  . PHE B 2 10  ? 20.98821 -15.86108 -2.35619  1.000 46.36949 ? 342 PHE B CG  1 
ATOM   412  C CD1 . PHE B 2 10  ? 21.82897 -16.14924 -1.29412  1.000 48.14293 ? 342 PHE B CD1 1 
ATOM   413  C CD2 . PHE B 2 10  ? 20.06475 -16.81380 -2.74612  1.000 43.03689 ? 342 PHE B CD2 1 
ATOM   414  C CE1 . PHE B 2 10  ? 21.75231 -17.36311 -0.64305  1.000 40.85898 ? 342 PHE B CE1 1 
ATOM   415  C CE2 . PHE B 2 10  ? 19.98413 -18.03315 -2.09448  1.000 42.39179 ? 342 PHE B CE2 1 
ATOM   416  C CZ  . PHE B 2 10  ? 20.82974 -18.30398 -1.03895  1.000 44.16286 ? 342 PHE B CZ  1 
ATOM   417  N N   . ASN B 2 11  ? 22.27871 -12.13456 -4.81569  1.000 60.48189 ? 343 ASN B N   1 
ATOM   418  C CA  . ASN B 2 11  ? 21.93425 -10.98197 -5.63859  1.000 60.18515 ? 343 ASN B CA  1 
ATOM   419  C C   . ASN B 2 11  ? 23.09643 -10.51498 -6.51264  1.000 60.17450 ? 343 ASN B C   1 
ATOM   420  O O   . ASN B 2 11  ? 23.06206 -9.39462  -7.03389  1.000 61.47733 ? 343 ASN B O   1 
ATOM   421  C CB  . ASN B 2 11  ? 21.43508 -9.83772  -4.75010  1.000 67.21920 ? 343 ASN B CB  1 
ATOM   422  C CG  . ASN B 2 11  ? 20.62815 -8.80182  -5.51865  1.000 72.72019 ? 343 ASN B CG  1 
ATOM   423  O OD1 . ASN B 2 11  ? 20.26098 -9.01561  -6.67465  1.000 75.65133 ? 343 ASN B OD1 1 
ATOM   424  N ND2 . ASN B 2 11  ? 20.34581 -7.67367  -4.87466  1.000 74.65927 ? 343 ASN B ND2 1 
ATOM   425  N N   . ALA B 2 12  ? 24.11896 -11.34902 -6.68882  1.000 55.63215 ? 344 ALA B N   1 
ATOM   426  C CA  . ALA B 2 12  ? 25.23876 -10.97971 -7.54280  1.000 54.37866 ? 344 ALA B CA  1 
ATOM   427  C C   . ALA B 2 12  ? 24.76567 -10.74288 -8.97413  1.000 56.90548 ? 344 ALA B C   1 
ATOM   428  O O   . ALA B 2 12  ? 23.84077 -11.39592 -9.46538  1.000 54.63648 ? 344 ALA B O   1 
ATOM   429  C CB  . ALA B 2 12  ? 26.31271 -12.06731 -7.51510  1.000 56.57877 ? 344 ALA B CB  1 
ATOM   430  N N   . THR B 2 13  ? 25.40968 -9.78435  -9.64269  1.000 53.52582 ? 345 THR B N   1 
ATOM   431  C CA  . THR B 2 13  ? 25.00034 -9.42025  -10.99547 1.000 59.01882 ? 345 THR B CA  1 
ATOM   432  C C   . THR B 2 13  ? 25.19571 -10.58344 -11.96031 1.000 56.59735 ? 345 THR B C   1 
ATOM   433  O O   . THR B 2 13  ? 24.29394 -10.92302 -12.73447 1.000 51.28644 ? 345 THR B O   1 
ATOM   434  C CB  . THR B 2 13  ? 25.78085 -8.19256  -11.46480 1.000 62.38446 ? 345 THR B CB  1 
ATOM   435  O OG1 . THR B 2 13  ? 25.65436 -7.14686  -10.49252 1.000 63.31743 ? 345 THR B OG1 1 
ATOM   436  C CG2 . THR B 2 13  ? 25.24648 -7.70122  -12.80413 1.000 54.03187 ? 345 THR B CG2 1 
ATOM   437  N N   . ARG B 2 14  ? 26.36428 -11.21513 -11.91828 1.000 60.56323 ? 346 ARG B N   1 
ATOM   438  C CA  . ARG B 2 14  ? 26.68648 -12.33313 -12.79065 1.000 54.79817 ? 346 ARG B CA  1 
ATOM   439  C C   . ARG B 2 14  ? 27.01196 -13.56103 -11.95280 1.000 52.03082 ? 346 ARG B C   1 
ATOM   440  O O   . ARG B 2 14  ? 27.71748 -13.46750 -10.94381 1.000 47.50428 ? 346 ARG B O   1 
ATOM   441  C CB  . ARG B 2 14  ? 27.86844 -11.99094 -13.70321 1.000 56.09385 ? 346 ARG B CB  1 
ATOM   442  C CG  . ARG B 2 14  ? 27.65621 -10.73611 -14.53439 1.000 57.29843 ? 346 ARG B CG  1 
ATOM   443  C CD  . ARG B 2 14  ? 28.95169 -10.26106 -15.17795 1.000 67.20701 ? 346 ARG B CD  1 
ATOM   444  N NE  . ARG B 2 14  ? 28.76632 -9.00951  -15.90429 1.000 75.85523 ? 346 ARG B NE  1 
ATOM   445  C CZ  . ARG B 2 14  ? 28.76335 -7.80961  -15.33898 1.000 74.57149 ? 346 ARG B CZ  1 
ATOM   446  N NH1 . ARG B 2 14  ? 28.93564 -7.65915  -14.03562 1.000 70.51663 ? 346 ARG B NH1 1 
ATOM   447  N NH2 . ARG B 2 14  ? 28.57868 -6.73423  -16.09983 1.000 81.70957 ? 346 ARG B NH2 1 
ATOM   448  N N   . PHE B 2 15  ? 26.48918 -14.70726 -12.37166 1.000 48.02387 ? 347 PHE B N   1 
ATOM   449  C CA  . PHE B 2 15  ? 26.80819 -15.98763 -11.76046 1.000 40.75171 ? 347 PHE B CA  1 
ATOM   450  C C   . PHE B 2 15  ? 27.88905 -16.69634 -12.56932 1.000 41.30300 ? 347 PHE B C   1 
ATOM   451  O O   . PHE B 2 15  ? 28.13483 -16.37855 -13.73531 1.000 44.77503 ? 347 PHE B O   1 
ATOM   452  C CB  . PHE B 2 15  ? 25.55523 -16.86482 -11.65598 1.000 40.14053 ? 347 PHE B CB  1 
ATOM   453  C CG  . PHE B 2 15  ? 24.81566 -16.72691 -10.34342 1.000 40.50322 ? 347 PHE B CG  1 
ATOM   454  C CD1 . PHE B 2 15  ? 24.59589 -15.47911 -9.77864  1.000 41.39281 ? 347 PHE B CD1 1 
ATOM   455  C CD2 . PHE B 2 15  ? 24.32656 -17.84618 -9.68937  1.000 38.24515 ? 347 PHE B CD2 1 
ATOM   456  C CE1 . PHE B 2 15  ? 23.91342 -15.35389 -8.57251  1.000 40.33412 ? 347 PHE B CE1 1 
ATOM   457  C CE2 . PHE B 2 15  ? 23.64530 -17.72668 -8.48344  1.000 41.51957 ? 347 PHE B CE2 1 
ATOM   458  C CZ  . PHE B 2 15  ? 23.43587 -16.47957 -7.92987  1.000 38.76145 ? 347 PHE B CZ  1 
ATOM   459  N N   . ALA B 2 16  ? 28.54138 -17.66294 -11.93111 1.000 40.98397 ? 348 ALA B N   1 
ATOM   460  C CA  . ALA B 2 16  ? 29.57827 -18.42788 -12.60504 1.000 41.98535 ? 348 ALA B CA  1 
ATOM   461  C C   . ALA B 2 16  ? 28.96553 -19.47939 -13.52637 1.000 40.19151 ? 348 ALA B C   1 
ATOM   462  O O   . ALA B 2 16  ? 27.81472 -19.89354 -13.36053 1.000 30.94252 ? 348 ALA B O   1 
ATOM   463  C CB  . ALA B 2 16  ? 30.49202 -19.11009 -11.58793 1.000 36.94290 ? 348 ALA B CB  1 
ATOM   464  N N   . SER B 2 17  ? 29.75090 -19.90329 -14.51730 1.000 39.22908 ? 349 SER B N   1 
ATOM   465  C CA  . SER B 2 17  ? 29.41900 -21.11798 -15.24736 1.000 34.81755 ? 349 SER B CA  1 
ATOM   466  C C   . SER B 2 17  ? 29.55540 -22.32222 -14.32563 1.000 34.38967 ? 349 SER B C   1 
ATOM   467  O O   . SER B 2 17  ? 30.40082 -22.35008 -13.42743 1.000 39.35030 ? 349 SER B O   1 
ATOM   468  C CB  . SER B 2 17  ? 30.32336 -21.29277 -16.46711 1.000 34.70319 ? 349 SER B CB  1 
ATOM   469  O OG  . SER B 2 17  ? 30.00811 -20.34316 -17.46686 1.000 37.34196 ? 349 SER B OG  1 
ATOM   470  N N   . VAL B 2 18  ? 28.70971 -23.32792 -14.55757 1.000 35.97838 ? 350 VAL B N   1 
ATOM   471  C CA  . VAL B 2 18  ? 28.62881 -24.45401 -13.63264 1.000 29.00062 ? 350 VAL B CA  1 
ATOM   472  C C   . VAL B 2 18  ? 29.94885 -25.21234 -13.58540 1.000 33.17511 ? 350 VAL B C   1 
ATOM   473  O O   . VAL B 2 18  ? 30.38922 -25.64709 -12.51548 1.000 34.10219 ? 350 VAL B O   1 
ATOM   474  C CB  . VAL B 2 18  ? 27.45157 -25.37555 -14.00544 1.000 31.03305 ? 350 VAL B CB  1 
ATOM   475  C CG1 . VAL B 2 18  ? 27.56888 -25.86556 -15.44893 1.000 30.01748 ? 350 VAL B CG1 1 
ATOM   476  C CG2 . VAL B 2 18  ? 27.36464 -26.54488 -13.03366 1.000 31.47257 ? 350 VAL B CG2 1 
ATOM   477  N N   . TYR B 2 19  ? 30.61837 -25.36239 -14.73110 1.000 33.01451 ? 351 TYR B N   1 
ATOM   478  C CA  . TYR B 2 19  ? 31.87127 -26.11110 -14.72668 1.000 33.91421 ? 351 TYR B CA  1 
ATOM   479  C C   . TYR B 2 19  ? 32.94995 -25.37351 -13.94165 1.000 30.61682 ? 351 TYR B C   1 
ATOM   480  O O   . TYR B 2 19  ? 33.85259 -26.00766 -13.38392 1.000 34.98585 ? 351 TYR B O   1 
ATOM   481  C CB  . TYR B 2 19  ? 32.32790 -26.39646 -16.16567 1.000 32.75144 ? 351 TYR B CB  1 
ATOM   482  C CG  . TYR B 2 19  ? 33.18743 -25.31528 -16.78516 1.000 35.33467 ? 351 TYR B CG  1 
ATOM   483  C CD1 . TYR B 2 19  ? 32.61573 -24.19970 -17.37996 1.000 33.56793 ? 351 TYR B CD1 1 
ATOM   484  C CD2 . TYR B 2 19  ? 34.57327 -25.41647 -16.77531 1.000 38.84632 ? 351 TYR B CD2 1 
ATOM   485  C CE1 . TYR B 2 19  ? 33.40082 -23.20872 -17.94416 1.000 37.96037 ? 351 TYR B CE1 1 
ATOM   486  C CE2 . TYR B 2 19  ? 35.36403 -24.43549 -17.33539 1.000 38.73709 ? 351 TYR B CE2 1 
ATOM   487  C CZ  . TYR B 2 19  ? 34.77474 -23.33516 -17.91714 1.000 40.68625 ? 351 TYR B CZ  1 
ATOM   488  O OH  . TYR B 2 19  ? 35.56383 -22.35874 -18.47898 1.000 42.33510 ? 351 TYR B OH  1 
ATOM   489  N N   . ALA B 2 20  ? 32.85108 -24.04558 -13.86086 1.000 32.18610 ? 352 ALA B N   1 
ATOM   490  C CA  . ALA B 2 20  ? 33.77962 -23.22851 -13.08830 1.000 36.03977 ? 352 ALA B CA  1 
ATOM   491  C C   . ALA B 2 20  ? 33.06035 -22.59044 -11.90576 1.000 38.05751 ? 352 ALA B C   1 
ATOM   492  O O   . ALA B 2 20  ? 33.20328 -21.38986 -11.64734 1.000 33.07199 ? 352 ALA B O   1 
ATOM   493  C CB  . ALA B 2 20  ? 34.40970 -22.15386 -13.97657 1.000 36.15999 ? 352 ALA B CB  1 
ATOM   494  N N   . TRP B 2 21  ? 32.28845 -23.39733 -11.18586 1.000 34.22523 ? 353 TRP B N   1 
ATOM   495  C CA  . TRP B 2 21  ? 31.38707 -22.88304 -10.16347 1.000 35.70748 ? 353 TRP B CA  1 
ATOM   496  C C   . TRP B 2 21  ? 32.14649 -22.12720 -9.07975  1.000 36.58350 ? 353 TRP B C   1 
ATOM   497  O O   . TRP B 2 21  ? 33.26530 -22.49201 -8.71371  1.000 31.75308 ? 353 TRP B O   1 
ATOM   498  C CB  . TRP B 2 21  ? 30.59836 -24.03706 -9.55073  1.000 33.74153 ? 353 TRP B CB  1 
ATOM   499  C CG  . TRP B 2 21  ? 31.43952 -25.22240 -9.15816  1.000 34.71405 ? 353 TRP B CG  1 
ATOM   500  C CD1 . TRP B 2 21  ? 31.81940 -26.25825 -9.95831  1.000 28.76503 ? 353 TRP B CD1 1 
ATOM   501  C CD2 . TRP B 2 21  ? 31.97666 -25.50369 -7.86063  1.000 32.20542 ? 353 TRP B CD2 1 
ATOM   502  N NE1 . TRP B 2 21  ? 32.57038 -27.16017 -9.24928  1.000 32.21711 ? 353 TRP B NE1 1 
ATOM   503  C CE2 . TRP B 2 21  ? 32.67763 -26.72231 -7.95455  1.000 36.26218 ? 353 TRP B CE2 1 
ATOM   504  C CE3 . TRP B 2 21  ? 31.93448 -24.84270 -6.62821  1.000 36.24704 ? 353 TRP B CE3 1 
ATOM   505  C CZ2 . TRP B 2 21  ? 33.33174 -27.29199 -6.86614  1.000 34.03283 ? 353 TRP B CZ2 1 
ATOM   506  C CZ3 . TRP B 2 21  ? 32.58336 -25.41070 -5.54809  1.000 35.81604 ? 353 TRP B CZ3 1 
ATOM   507  C CH2 . TRP B 2 21  ? 33.27460 -26.62299 -5.67417  1.000 36.91868 ? 353 TRP B CH2 1 
ATOM   508  N N   . ASN B 2 22  ? 31.52999 -21.06125 -8.57388  1.000 34.38668 ? 354 ASN B N   1 
ATOM   509  C CA  . ASN B 2 22  ? 32.13928 -20.22163 -7.55438  1.000 33.78508 ? 354 ASN B CA  1 
ATOM   510  C C   . ASN B 2 22  ? 31.82897 -20.76107 -6.16656  1.000 34.42625 ? 354 ASN B C   1 
ATOM   511  O O   . ASN B 2 22  ? 30.77626 -21.35993 -5.93386  1.000 30.59755 ? 354 ASN B O   1 
ATOM   512  C CB  . ASN B 2 22  ? 31.64214 -18.77827 -7.66372  1.000 36.55810 ? 354 ASN B CB  1 
ATOM   513  C CG  . ASN B 2 22  ? 32.32702 -17.85455 -6.67586  1.000 51.70315 ? 354 ASN B CG  1 
ATOM   514  O OD1 . ASN B 2 22  ? 31.75498 -17.48369 -5.64726  1.000 54.17210 ? 354 ASN B OD1 1 
ATOM   515  N ND2 . ASN B 2 22  ? 33.57078 -17.49305 -6.97398  1.000 58.89036 ? 354 ASN B ND2 1 
ATOM   516  N N   . ARG B 2 23  ? 32.76502 -20.54728 -5.24455  1.000 33.51226 ? 355 ARG B N   1 
ATOM   517  C CA  . ARG B 2 23  ? 32.56271 -20.85658 -3.83696  1.000 35.30812 ? 355 ARG B CA  1 
ATOM   518  C C   . ARG B 2 23  ? 32.93158 -19.64017 -3.00107  1.000 41.11366 ? 355 ARG B C   1 
ATOM   519  O O   . ARG B 2 23  ? 33.95015 -18.98665 -3.25030  1.000 38.16483 ? 355 ARG B O   1 
ATOM   520  C CB  . ARG B 2 23  ? 33.39034 -22.07088 -3.39938  1.000 34.73481 ? 355 ARG B CB  1 
ATOM   521  C CG  . ARG B 2 23  ? 33.45450 -22.25134 -1.88325  1.000 38.58949 ? 355 ARG B CG  1 
ATOM   522  C CD  . ARG B 2 23  ? 33.94355 -23.63404 -1.49477  1.000 36.32233 ? 355 ARG B CD  1 
ATOM   523  N NE  . ARG B 2 23  ? 32.91000 -24.64567 -1.67755  1.000 35.33256 ? 355 ARG B NE  1 
ATOM   524  C CZ  . ARG B 2 23  ? 33.03439 -25.91547 -1.31723  1.000 39.47274 ? 355 ARG B CZ  1 
ATOM   525  N NH1 . ARG B 2 23  ? 34.14319 -26.36900 -0.75647  1.000 43.23791 ? 355 ARG B NH1 1 
ATOM   526  N NH2 . ARG B 2 23  ? 32.02085 -26.75147 -1.52449  1.000 39.61356 ? 355 ARG B NH2 1 
ATOM   527  N N   . LYS B 2 24  ? 32.09089 -19.33842 -2.01521  1.000 40.37210 ? 356 LYS B N   1 
ATOM   528  C CA  . LYS B 2 24  ? 32.28434 -18.21404 -1.11041  1.000 40.29664 ? 356 LYS B CA  1 
ATOM   529  C C   . LYS B 2 24  ? 32.26477 -18.74975 0.31338   1.000 37.99516 ? 356 LYS B C   1 
ATOM   530  O O   . LYS B 2 24  ? 31.31257 -19.43408 0.70582   1.000 38.25922 ? 356 LYS B O   1 
ATOM   531  C CB  . LYS B 2 24  ? 31.19156 -17.16044 -1.31602  1.000 42.59969 ? 356 LYS B CB  1 
ATOM   532  C CG  . LYS B 2 24  ? 31.17620 -16.04264 -0.28487  1.000 46.32116 ? 356 LYS B CG  1 
ATOM   533  C CD  . LYS B 2 24  ? 32.30359 -15.05562 -0.51673  1.000 46.43744 ? 356 LYS B CD  1 
ATOM   534  C CE  . LYS B 2 24  ? 32.33859 -13.99241 0.57171   1.000 54.94813 ? 356 LYS B CE  1 
ATOM   535  N NZ  . LYS B 2 24  ? 33.45964 -13.03440 0.35951   1.000 57.20991 ? 356 LYS B NZ  1 
ATOM   536  N N   . ARG B 2 25  ? 33.32011 -18.46570 1.07399   1.000 38.70902 ? 357 ARG B N   1 
ATOM   537  C CA  . ARG B 2 25  ? 33.37516 -18.86477 2.47541   1.000 37.73256 ? 357 ARG B CA  1 
ATOM   538  C C   . ARG B 2 25  ? 32.68380 -17.80890 3.32668   1.000 41.71422 ? 357 ARG B C   1 
ATOM   539  O O   . ARG B 2 25  ? 33.02127 -16.62339 3.25096   1.000 36.79809 ? 357 ARG B O   1 
ATOM   540  C CB  . ARG B 2 25  ? 34.81925 -19.06058 2.94291   1.000 41.86050 ? 357 ARG B CB  1 
ATOM   541  C CG  . ARG B 2 25  ? 34.95226 -19.33284 4.45404   1.000 44.80422 ? 357 ARG B CG  1 
ATOM   542  C CD  . ARG B 2 25  ? 36.39762 -19.21143 4.93669   1.000 51.39129 ? 357 ARG B CD  1 
ATOM   543  N NE  . ARG B 2 25  ? 37.21700 -20.36168 4.56986   1.000 57.76292 ? 357 ARG B NE  1 
ATOM   544  C CZ  . ARG B 2 25  ? 37.62050 -21.30145 5.41619   1.000 59.28587 ? 357 ARG B CZ  1 
ATOM   545  N NH1 . ARG B 2 25  ? 37.31139 -21.25433 6.70150   1.000 57.62593 ? 357 ARG B NH1 1 
ATOM   546  N NH2 . ARG B 2 25  ? 38.35835 -22.31200 4.96203   1.000 61.38802 ? 357 ARG B NH2 1 
ATOM   547  N N   . ILE B 2 26  ? 31.71034 -18.24311 4.12161   1.000 40.31911 ? 358 ILE B N   1 
ATOM   548  C CA  . ILE B 2 26  ? 30.96551 -17.37718 5.02761   1.000 42.81051 ? 358 ILE B CA  1 
ATOM   549  C C   . ILE B 2 26  ? 31.40385 -17.72325 6.44533   1.000 37.14676 ? 358 ILE B C   1 
ATOM   550  O O   . ILE B 2 26  ? 31.32284 -18.88744 6.85543   1.000 39.14398 ? 358 ILE B O   1 
ATOM   551  C CB  . ILE B 2 26  ? 29.44757 -17.55303 4.85768   1.000 40.25537 ? 358 ILE B CB  1 
ATOM   552  C CG1 . ILE B 2 26  ? 29.02426 -17.27301 3.41007   1.000 37.26646 ? 358 ILE B CG1 1 
ATOM   553  C CG2 . ILE B 2 26  ? 28.68971 -16.65155 5.81767   1.000 44.55754 ? 358 ILE B CG2 1 
ATOM   554  C CD1 . ILE B 2 26  ? 29.13365 -15.82011 3.01059   1.000 45.63582 ? 358 ILE B CD1 1 
ATOM   555  N N   . SER B 2 27  ? 31.87805 -16.72403 7.18945   1.000 44.94109 ? 359 SER B N   1 
ATOM   556  C CA  . SER B 2 27  ? 32.34992 -16.95829 8.55070   1.000 51.98710 ? 359 SER B CA  1 
ATOM   557  C C   . SER B 2 27  ? 32.32189 -15.65674 9.34307   1.000 50.50167 ? 359 SER B C   1 
ATOM   558  O O   . SER B 2 27  ? 32.32554 -14.56041 8.77580   1.000 49.71424 ? 359 SER B O   1 
ATOM   559  C CB  . SER B 2 27  ? 33.76257 -17.55444 8.56009   1.000 51.50876 ? 359 SER B CB  1 
ATOM   560  O OG  . SER B 2 27  ? 34.69287 -16.65842 7.98040   1.000 56.88467 ? 359 SER B OG  1 
ATOM   561  N N   . ASN B 2 28  ? 32.30034 -15.80226 10.66961  1.000 57.75384 ? 360 ASN B N   1 
ATOM   562  C CA  . ASN B 2 28  ? 32.36960 -14.68446 11.61529  1.000 54.91960 ? 360 ASN B CA  1 
ATOM   563  C C   . ASN B 2 28  ? 31.30952 -13.62595 11.31291  1.000 52.64533 ? 360 ASN B C   1 
ATOM   564  O O   . ASN B 2 28  ? 31.61054 -12.46157 11.04210  1.000 52.66328 ? 360 ASN B O   1 
ATOM   565  C CB  . ASN B 2 28  ? 33.76706 -14.05927 11.62177  1.000 57.84462 ? 360 ASN B CB  1 
ATOM   566  C CG  . ASN B 2 28  ? 34.75377 -14.84016 12.46084  1.000 60.01194 ? 360 ASN B CG  1 
ATOM   567  O OD1 . ASN B 2 28  ? 34.67360 -14.84462 13.68932  1.000 72.69515 ? 360 ASN B OD1 1 
ATOM   568  N ND2 . ASN B 2 28  ? 35.70285 -15.49489 11.80190  1.000 65.16278 ? 360 ASN B ND2 1 
ATOM   569  N N   . CYS B 2 29  ? 30.05027 -14.04851 11.37347  1.000 51.40933 ? 361 CYS B N   1 
ATOM   570  C CA  . CYS B 2 29  ? 28.94891 -13.15357 11.04813  1.000 52.44989 ? 361 CYS B CA  1 
ATOM   571  C C   . CYS B 2 29  ? 27.64615 -13.75167 11.55853  1.000 53.21278 ? 361 CYS B C   1 
ATOM   572  O O   . CYS B 2 29  ? 27.58131 -14.91922 11.95449  1.000 51.67751 ? 361 CYS B O   1 
ATOM   573  C CB  . CYS B 2 29  ? 28.87417 -12.88947 9.53959   1.000 60.77221 ? 361 CYS B CB  1 
ATOM   574  S SG  . CYS B 2 29  ? 28.70619 -14.38529 8.53652   1.000 52.35403 ? 361 CYS B SG  1 
ATOM   575  N N   . VAL B 2 30  ? 26.60414 -12.92377 11.54086  1.000 53.11915 ? 362 VAL B N   1 
ATOM   576  C CA  . VAL B 2 30  ? 25.25575 -13.31895 11.92874  1.000 55.83581 ? 362 VAL B CA  1 
ATOM   577  C C   . VAL B 2 30  ? 24.39625 -13.35390 10.67397  1.000 55.38242 ? 362 VAL B C   1 
ATOM   578  O O   . VAL B 2 30  ? 24.33910 -12.37100 9.92530   1.000 54.33336 ? 362 VAL B O   1 
ATOM   579  C CB  . VAL B 2 30  ? 24.66591 -12.35954 12.97548  1.000 58.09575 ? 362 VAL B CB  1 
ATOM   580  C CG1 . VAL B 2 30  ? 23.24650 -12.77130 13.32911  1.000 59.09081 ? 362 VAL B CG1 1 
ATOM   581  C CG2 . VAL B 2 30  ? 25.54845 -12.33067 14.21752  1.000 59.62183 ? 362 VAL B CG2 1 
ATOM   582  N N   . ALA B 2 31  ? 23.72800 -14.47998 10.44667  1.000 56.51139 ? 363 ALA B N   1 
ATOM   583  C CA  . ALA B 2 31  ? 22.96924 -14.71209 9.22288   1.000 63.16374 ? 363 ALA B CA  1 
ATOM   584  C C   . ALA B 2 31  ? 21.48022 -14.66418 9.53818   1.000 63.32024 ? 363 ALA B C   1 
ATOM   585  O O   . ALA B 2 31  ? 20.95837 -15.53720 10.23935  1.000 67.40527 ? 363 ALA B O   1 
ATOM   586  C CB  . ALA B 2 31  ? 23.35052 -16.04951 8.59277   1.000 62.80250 ? 363 ALA B CB  1 
ATOM   587  N N   . ASP B 2 32  ? 20.80021 -13.64479 9.02225   1.000 65.48830 ? 364 ASP B N   1 
ATOM   588  C CA  . ASP B 2 32  ? 19.34046 -13.59964 9.05182   1.000 69.40009 ? 364 ASP B CA  1 
ATOM   589  C C   . ASP B 2 32  ? 18.84643 -14.41054 7.86182   1.000 71.04172 ? 364 ASP B C   1 
ATOM   590  O O   . ASP B 2 32  ? 18.72181 -13.90603 6.74597   1.000 67.04713 ? 364 ASP B O   1 
ATOM   591  C CB  . ASP B 2 32  ? 18.83834 -12.16158 9.00571   1.000 70.51718 ? 364 ASP B CB  1 
ATOM   592  C CG  . ASP B 2 32  ? 17.32604 -12.06491 9.11524   1.000 71.90570 ? 364 ASP B CG  1 
ATOM   593  O OD1 . ASP B 2 32  ? 16.67913 -13.08734 9.42991   1.000 73.51063 ? 364 ASP B OD1 1 
ATOM   594  O OD2 . ASP B 2 32  ? 16.78377 -10.96368 8.88324   1.000 71.06207 ? 364 ASP B OD2 1 
ATOM   595  N N   . TYR B 2 33  ? 18.56728 -15.69289 8.10047   1.000 69.06282 ? 365 TYR B N   1 
ATOM   596  C CA  . TYR B 2 33  ? 18.16359 -16.58233 7.01756   1.000 67.55149 ? 365 TYR B CA  1 
ATOM   597  C C   . TYR B 2 33  ? 16.75727 -16.30001 6.50230   1.000 74.55442 ? 365 TYR B C   1 
ATOM   598  O O   . TYR B 2 33  ? 16.30924 -16.98968 5.57842   1.000 73.12531 ? 365 TYR B O   1 
ATOM   599  C CB  . TYR B 2 33  ? 18.27150 -18.04125 7.46670   1.000 63.27804 ? 365 TYR B CB  1 
ATOM   600  C CG  . TYR B 2 33  ? 19.69577 -18.53895 7.60777   1.000 68.71129 ? 365 TYR B CG  1 
ATOM   601  C CD1 . TYR B 2 33  ? 20.44328 -18.89739 6.48951   1.000 67.52606 ? 365 TYR B CD1 1 
ATOM   602  C CD2 . TYR B 2 33  ? 20.29081 -18.65958 8.85935   1.000 69.36064 ? 365 TYR B CD2 1 
ATOM   603  C CE1 . TYR B 2 33  ? 21.74417 -19.35641 6.61385   1.000 61.64271 ? 365 TYR B CE1 1 
ATOM   604  C CE2 . TYR B 2 33  ? 21.59090 -19.11877 8.99414   1.000 63.93203 ? 365 TYR B CE2 1 
ATOM   605  C CZ  . TYR B 2 33  ? 22.31239 -19.46524 7.86903   1.000 67.96087 ? 365 TYR B CZ  1 
ATOM   606  O OH  . TYR B 2 33  ? 23.60499 -19.92192 8.00118   1.000 60.85857 ? 365 TYR B OH  1 
ATOM   607  N N   . SER B 2 34  ? 16.05602 -15.31182 7.06198   1.000 74.20387 ? 366 SER B N   1 
ATOM   608  C CA  . SER B 2 34  ? 14.72987 -14.96548 6.56365   1.000 71.64318 ? 366 SER B CA  1 
ATOM   609  C C   . SER B 2 34  ? 14.81191 -14.18755 5.25719   1.000 76.34449 ? 366 SER B C   1 
ATOM   610  O O   . SER B 2 34  ? 14.00286 -14.41175 4.34998   1.000 80.27987 ? 366 SER B O   1 
ATOM   611  C CB  . SER B 2 34  ? 13.96189 -14.16511 7.61639   1.000 76.21945 ? 366 SER B CB  1 
ATOM   612  O OG  . SER B 2 34  ? 13.71515 -14.95097 8.77044   1.000 81.88596 ? 366 SER B OG  1 
ATOM   613  N N   . VAL B 2 35  ? 15.78150 -13.27437 5.14079   1.000 75.83466 ? 367 VAL B N   1 
ATOM   614  C CA  . VAL B 2 35  ? 15.99258 -12.56093 3.88606   1.000 76.68004 ? 367 VAL B CA  1 
ATOM   615  C C   . VAL B 2 35  ? 16.36460 -13.52607 2.76969   1.000 79.44284 ? 367 VAL B C   1 
ATOM   616  O O   . VAL B 2 35  ? 16.21303 -13.20015 1.58655   1.000 80.14948 ? 367 VAL B O   1 
ATOM   617  C CB  . VAL B 2 35  ? 17.06867 -11.46554 4.06376   1.000 74.03277 ? 367 VAL B CB  1 
ATOM   618  C CG1 . VAL B 2 35  ? 18.45747 -12.08102 4.15337   1.000 76.36691 ? 367 VAL B CG1 1 
ATOM   619  C CG2 . VAL B 2 35  ? 16.99708 -10.44761 2.93254   1.000 76.98564 ? 367 VAL B CG2 1 
ATOM   620  N N   . LEU B 2 36  ? 16.84085 -14.72131 3.12223   1.000 79.08971 ? 368 LEU B N   1 
ATOM   621  C CA  . LEU B 2 36  ? 17.13487 -15.73580 2.11845   1.000 77.97791 ? 368 LEU B CA  1 
ATOM   622  C C   . LEU B 2 36  ? 15.84908 -16.32176 1.54965   1.000 78.34475 ? 368 LEU B C   1 
ATOM   623  O O   . LEU B 2 36  ? 15.66596 -16.37109 0.32776   1.000 77.77363 ? 368 LEU B O   1 
ATOM   624  C CB  . LEU B 2 36  ? 18.01243 -16.82754 2.73600   1.000 73.47622 ? 368 LEU B CB  1 
ATOM   625  C CG  . LEU B 2 36  ? 18.69415 -17.87562 1.85528   1.000 65.64860 ? 368 LEU B CG  1 
ATOM   626  C CD1 . LEU B 2 36  ? 19.92288 -18.41440 2.56806   1.000 60.81089 ? 368 LEU B CD1 1 
ATOM   627  C CD2 . LEU B 2 36  ? 17.74620 -19.01370 1.51954   1.000 66.41584 ? 368 LEU B CD2 1 
ATOM   628  N N   . TYR B 2 37  ? 14.93901 -16.75738 2.42801   1.000 77.10823 ? 369 TYR B N   1 
ATOM   629  C CA  . TYR B 2 37  ? 13.71845 -17.43199 1.99766   1.000 78.37744 ? 369 TYR B CA  1 
ATOM   630  C C   . TYR B 2 37  ? 12.81865 -16.54644 1.14434   1.000 80.59168 ? 369 TYR B C   1 
ATOM   631  O O   . TYR B 2 37  ? 12.04615 -17.07113 0.33631   1.000 80.00822 ? 369 TYR B O   1 
ATOM   632  C CB  . TYR B 2 37  ? 12.94212 -17.93548 3.21843   1.000 78.32057 ? 369 TYR B CB  1 
ATOM   633  N N   . ASN B 2 38  ? 12.89511 -15.22513 1.30063   1.000 81.19850 ? 370 ASN B N   1 
ATOM   634  C CA  . ASN B 2 38  ? 12.05285 -14.30316 0.54996   1.000 81.59721 ? 370 ASN B CA  1 
ATOM   635  C C   . ASN B 2 38  ? 12.82985 -13.54492 -0.52302  1.000 79.42164 ? 370 ASN B C   1 
ATOM   636  O O   . ASN B 2 38  ? 12.34459 -12.52904 -1.03117  1.000 80.13949 ? 370 ASN B O   1 
ATOM   637  C CB  . ASN B 2 38  ? 11.36497 -13.32425 1.50313   1.000 74.51188 ? 370 ASN B CB  1 
ATOM   638  N N   . PHE B 2 39  ? 14.02908 -14.01548 -0.87847  1.000 78.23317 ? 371 PHE B N   1 
ATOM   639  C CA  . PHE B 2 39  ? 14.79845 -13.34182 -1.91927  1.000 75.89200 ? 371 PHE B CA  1 
ATOM   640  C C   . PHE B 2 39  ? 14.12987 -13.46641 -3.28060  1.000 74.77950 ? 371 PHE B C   1 
ATOM   641  O O   . PHE B 2 39  ? 14.20465 -12.53735 -4.09237  1.000 75.76557 ? 371 PHE B O   1 
ATOM   642  C CB  . PHE B 2 39  ? 16.22220 -13.90240 -1.97988  1.000 75.12940 ? 371 PHE B CB  1 
ATOM   643  C CG  . PHE B 2 39  ? 17.03713 -13.37287 -3.13469  1.000 66.69073 ? 371 PHE B CG  1 
ATOM   644  C CD1 . PHE B 2 39  ? 17.65028 -12.13069 -3.05639  1.000 67.30057 ? 371 PHE B CD1 1 
ATOM   645  C CD2 . PHE B 2 39  ? 17.18656 -14.11666 -4.29725  1.000 63.88655 ? 371 PHE B CD2 1 
ATOM   646  C CE1 . PHE B 2 39  ? 18.39507 -11.63888 -4.11299  1.000 69.24029 ? 371 PHE B CE1 1 
ATOM   647  C CE2 . PHE B 2 39  ? 17.92951 -13.63207 -5.35928  1.000 61.11839 ? 371 PHE B CE2 1 
ATOM   648  C CZ  . PHE B 2 39  ? 18.53507 -12.39129 -5.26841  1.000 65.85258 ? 371 PHE B CZ  1 
ATOM   649  N N   . ALA B 2 40  ? 13.47567 -14.59167 -3.54724  1.000 70.95066 ? 372 ALA B N   1 
ATOM   650  C CA  . ALA B 2 40  ? 12.87845 -14.84713 -4.84895  1.000 69.93151 ? 372 ALA B CA  1 
ATOM   651  C C   . ALA B 2 40  ? 11.90256 -16.00512 -4.70844  1.000 68.22887 ? 372 ALA B C   1 
ATOM   652  O O   . ALA B 2 40  ? 11.97570 -16.76630 -3.73617  1.000 66.00997 ? 372 ALA B O   1 
ATOM   653  C CB  . ALA B 2 40  ? 13.95459 -15.17073 -5.90017  1.000 67.10048 ? 372 ALA B CB  1 
ATOM   654  N N   . PRO B 2 41  ? 10.96215 -16.15479 -5.65159  1.000 65.72079 ? 373 PRO B N   1 
ATOM   655  C CA  . PRO B 2 41  ? 10.15620 -17.38264 -5.68745  1.000 59.77490 ? 373 PRO B CA  1 
ATOM   656  C C   . PRO B 2 41  ? 10.99938 -18.57671 -6.10890  1.000 58.23420 ? 373 PRO B C   1 
ATOM   657  O O   . PRO B 2 41  ? 11.20611 -18.81717 -7.30307  1.000 55.92350 ? 373 PRO B O   1 
ATOM   658  C CB  . PRO B 2 41  ? 9.06171  -17.05906 -6.71220  1.000 63.49029 ? 373 PRO B CB  1 
ATOM   659  C CG  . PRO B 2 41  ? 9.65695  -15.98856 -7.57394  1.000 67.06232 ? 373 PRO B CG  1 
ATOM   660  C CD  . PRO B 2 41  ? 10.52419 -15.17368 -6.66035  1.000 67.44789 ? 373 PRO B CD  1 
ATOM   661  N N   . PHE B 2 42  ? 11.49646 -19.32547 -5.12761  1.000 57.02544 ? 374 PHE B N   1 
ATOM   662  C CA  . PHE B 2 42  ? 12.42630 -20.41265 -5.40140  1.000 50.90581 ? 374 PHE B CA  1 
ATOM   663  C C   . PHE B 2 42  ? 11.70734 -21.59293 -6.03944  1.000 49.18094 ? 374 PHE B C   1 
ATOM   664  O O   . PHE B 2 42  ? 10.67588 -22.05209 -5.53975  1.000 49.56240 ? 374 PHE B O   1 
ATOM   665  C CB  . PHE B 2 42  ? 13.11513 -20.85513 -4.11024  1.000 49.12885 ? 374 PHE B CB  1 
ATOM   666  C CG  . PHE B 2 42  ? 13.99632 -19.80410 -3.50372  1.000 51.94254 ? 374 PHE B CG  1 
ATOM   667  C CD1 . PHE B 2 42  ? 14.83893 -19.04450 -4.29751  1.000 50.57200 ? 374 PHE B CD1 1 
ATOM   668  C CD2 . PHE B 2 42  ? 13.97463 -19.56789 -2.13984  1.000 57.13640 ? 374 PHE B CD2 1 
ATOM   669  C CE1 . PHE B 2 42  ? 15.65026 -18.07502 -3.74372  1.000 54.50372 ? 374 PHE B CE1 1 
ATOM   670  C CE2 . PHE B 2 42  ? 14.78230 -18.60025 -1.57926  1.000 59.83940 ? 374 PHE B CE2 1 
ATOM   671  C CZ  . PHE B 2 42  ? 15.62143 -17.85182 -2.38122  1.000 61.55356 ? 374 PHE B CZ  1 
ATOM   672  N N   . SER B 2 43  ? 12.25738 -22.08365 -7.15019  1.000 49.97309 ? 375 SER B N   1 
ATOM   673  C CA  . SER B 2 43  ? 11.75417 -23.29646 -7.77953  1.000 46.97093 ? 375 SER B CA  1 
ATOM   674  C C   . SER B 2 43  ? 12.35482 -24.55406 -7.17174  1.000 44.08884 ? 375 SER B C   1 
ATOM   675  O O   . SER B 2 43  ? 11.83738 -25.65017 -7.41147  1.000 51.85281 ? 375 SER B O   1 
ATOM   676  C CB  . SER B 2 43  ? 12.03730 -23.26660 -9.28299  1.000 46.08566 ? 375 SER B CB  1 
ATOM   677  O OG  . SER B 2 43  ? 13.43320 -23.29483 -9.51826  1.000 46.25645 ? 375 SER B OG  1 
ATOM   678  N N   . ALA B 2 44  ? 13.43207 -24.42328 -6.39940  1.000 45.15928 ? 376 ALA B N   1 
ATOM   679  C CA  . ALA B 2 44  ? 14.00131 -25.53393 -5.65449  1.000 41.95461 ? 376 ALA B CA  1 
ATOM   680  C C   . ALA B 2 44  ? 14.47327 -25.02750 -4.30071  1.000 39.67077 ? 376 ALA B C   1 
ATOM   681  O O   . ALA B 2 44  ? 15.01550 -23.92524 -4.19387  1.000 36.42500 ? 376 ALA B O   1 
ATOM   682  C CB  . ALA B 2 44  ? 15.16451 -26.19143 -6.40710  1.000 42.36799 ? 376 ALA B CB  1 
ATOM   683  N N   . PHE B 2 45  ? 14.24109 -25.83416 -3.26791  1.000 43.07492 ? 377 PHE B N   1 
ATOM   684  C CA  . PHE B 2 45  ? 14.69400 -25.50889 -1.91476  1.000 43.97205 ? 377 PHE B CA  1 
ATOM   685  C C   . PHE B 2 45  ? 14.58358 -26.80020 -1.09968  1.000 44.25122 ? 377 PHE B C   1 
ATOM   686  O O   . PHE B 2 45  ? 13.49724 -27.14365 -0.63614  1.000 46.30851 ? 377 PHE B O   1 
ATOM   687  C CB  . PHE B 2 45  ? 13.86844 -24.39055 -1.29914  1.000 45.45627 ? 377 PHE B CB  1 
ATOM   688  C CG  . PHE B 2 45  ? 14.54236 -23.70357 -0.13531  1.000 50.24346 ? 377 PHE B CG  1 
ATOM   689  C CD1 . PHE B 2 45  ? 14.74984 -24.36995 1.06010   1.000 50.78338 ? 377 PHE B CD1 1 
ATOM   690  C CD2 . PHE B 2 45  ? 14.95839 -22.38651 -0.23900  1.000 51.35140 ? 377 PHE B CD2 1 
ATOM   691  C CE1 . PHE B 2 45  ? 15.36898 -23.74100 2.12697   1.000 53.53258 ? 377 PHE B CE1 1 
ATOM   692  C CE2 . PHE B 2 45  ? 15.57728 -21.75153 0.82591   1.000 49.69095 ? 377 PHE B CE2 1 
ATOM   693  C CZ  . PHE B 2 45  ? 15.78348 -22.42990 2.00801   1.000 50.59294 ? 377 PHE B CZ  1 
ATOM   694  N N   . LYS B 2 46  ? 15.70101 -27.50136 -0.95276  1.000 41.03434 ? 378 LYS B N   1 
ATOM   695  C CA  . LYS B 2 46  ? 15.73289 -28.75528 -0.21214  1.000 41.00839 ? 378 LYS B CA  1 
ATOM   696  C C   . LYS B 2 46  ? 16.97150 -28.76876 0.66825   1.000 45.62389 ? 378 LYS B C   1 
ATOM   697  O O   . LYS B 2 46  ? 18.07894 -28.49626 0.19398   1.000 40.18046 ? 378 LYS B O   1 
ATOM   698  C CB  . LYS B 2 46  ? 15.73910 -29.97088 -1.14986  1.000 45.61372 ? 378 LYS B CB  1 
ATOM   699  C CG  . LYS B 2 46  ? 15.66944 -31.30362 -0.41251  1.000 48.87666 ? 378 LYS B CG  1 
ATOM   700  C CD  . LYS B 2 46  ? 15.39763 -32.46381 -1.35595  1.000 54.36517 ? 378 LYS B CD  1 
ATOM   701  C CE  . LYS B 2 46  ? 15.20456 -33.76737 -0.58597  1.000 57.04410 ? 378 LYS B CE  1 
ATOM   702  N NZ  . LYS B 2 46  ? 14.81801 -34.90368 -1.47513  1.000 61.25453 ? 378 LYS B NZ  1 
ATOM   703  N N   . CYS B 2 47  ? 16.78381 -29.06627 1.94904   1.000 41.61587 ? 379 CYS B N   1 
ATOM   704  C CA  . CYS B 2 47  ? 17.89605 -29.14519 2.87921   1.000 43.74932 ? 379 CYS B CA  1 
ATOM   705  C C   . CYS B 2 47  ? 18.15329 -30.59567 3.26166   1.000 40.70594 ? 379 CYS B C   1 
ATOM   706  O O   . CYS B 2 47  ? 17.25716 -31.44256 3.21060   1.000 47.18782 ? 379 CYS B O   1 
ATOM   707  C CB  . CYS B 2 47  ? 17.63879 -28.29335 4.12189   1.000 45.48867 ? 379 CYS B CB  1 
ATOM   708  S SG  . CYS B 2 47  ? 17.52461 -26.51618 3.76130   1.000 50.55694 ? 379 CYS B SG  1 
ATOM   709  N N   . TYR B 2 48  ? 19.40454 -30.87432 3.61209   1.000 42.04720 ? 380 TYR B N   1 
ATOM   710  C CA  . TYR B 2 48  ? 19.84985 -32.20684 3.99273   1.000 47.22482 ? 380 TYR B CA  1 
ATOM   711  C C   . TYR B 2 48  ? 20.58441 -32.08954 5.32202   1.000 49.03212 ? 380 TYR B C   1 
ATOM   712  O O   . TYR B 2 48  ? 21.51890 -31.28909 5.44946   1.000 43.02998 ? 380 TYR B O   1 
ATOM   713  C CB  . TYR B 2 48  ? 20.75711 -32.81475 2.91724   1.000 41.04597 ? 380 TYR B CB  1 
ATOM   714  C CG  . TYR B 2 48  ? 20.14707 -32.88976 1.52418   1.000 47.62691 ? 380 TYR B CG  1 
ATOM   715  C CD1 . TYR B 2 48  ? 20.16178 -31.79095 0.67507   1.000 43.95629 ? 380 TYR B CD1 1 
ATOM   716  C CD2 . TYR B 2 48  ? 19.57948 -34.06729 1.05537   1.000 42.88039 ? 380 TYR B CD2 1 
ATOM   717  C CE1 . TYR B 2 48  ? 19.61687 -31.86103 -0.60757  1.000 44.12252 ? 380 TYR B CE1 1 
ATOM   718  C CE2 . TYR B 2 48  ? 19.03276 -34.14884 -0.21463  1.000 46.92734 ? 380 TYR B CE2 1 
ATOM   719  C CZ  . TYR B 2 48  ? 19.05177 -33.04468 -1.04197  1.000 45.54491 ? 380 TYR B CZ  1 
ATOM   720  O OH  . TYR B 2 48  ? 18.50849 -33.13312 -2.30509  1.000 50.00164 ? 380 TYR B OH  1 
ATOM   721  N N   . GLY B 2 49  ? 20.15522 -32.86952 6.31210   1.000 52.55082 ? 381 GLY B N   1 
ATOM   722  C CA  . GLY B 2 49  ? 20.77361 -32.84644 7.62226   1.000 50.02798 ? 381 GLY B CA  1 
ATOM   723  C C   . GLY B 2 49  ? 20.43168 -31.64823 8.47944   1.000 56.14193 ? 381 GLY B C   1 
ATOM   724  O O   . GLY B 2 49  ? 20.90166 -31.57241 9.62352   1.000 57.74782 ? 381 GLY B O   1 
ATOM   725  N N   . VAL B 2 50  ? 19.63699 -30.70950 7.96899   1.000 53.86287 ? 382 VAL B N   1 
ATOM   726  C CA  . VAL B 2 50  ? 19.21133 -29.53451 8.71644   1.000 56.74999 ? 382 VAL B CA  1 
ATOM   727  C C   . VAL B 2 50  ? 17.76072 -29.24050 8.36468   1.000 61.57841 ? 382 VAL B C   1 
ATOM   728  O O   . VAL B 2 50  ? 17.27991 -29.58989 7.28223   1.000 59.85921 ? 382 VAL B O   1 
ATOM   729  C CB  . VAL B 2 50  ? 20.09469 -28.29789 8.42405   1.000 61.44395 ? 382 VAL B CB  1 
ATOM   730  C CG1 . VAL B 2 50  ? 21.48735 -28.47361 9.01141   1.000 60.77364 ? 382 VAL B CG1 1 
ATOM   731  C CG2 . VAL B 2 50  ? 20.17037 -28.03942 6.92382   1.000 52.94530 ? 382 VAL B CG2 1 
ATOM   732  N N   . SER B 2 51  ? 17.06271 -28.59576 9.29105   1.000 64.52857 ? 383 SER B N   1 
ATOM   733  C CA  . SER B 2 51  ? 15.70694 -28.14480 9.00260   1.000 67.49030 ? 383 SER B CA  1 
ATOM   734  C C   . SER B 2 51  ? 15.75283 -26.75756 8.37568   1.000 65.67450 ? 383 SER B C   1 
ATOM   735  O O   . SER B 2 51  ? 16.44140 -25.87342 8.89799   1.000 68.47057 ? 383 SER B O   1 
ATOM   736  C CB  . SER B 2 51  ? 14.86265 -28.11201 10.26845  1.000 68.24574 ? 383 SER B CB  1 
ATOM   737  O OG  . SER B 2 51  ? 13.53969 -27.68619 9.99021   1.000 70.42537 ? 383 SER B OG  1 
ATOM   738  N N   . PRO B 2 52  ? 15.05172 -26.53250 7.26196   1.000 68.34644 ? 384 PRO B N   1 
ATOM   739  C CA  . PRO B 2 52  ? 15.13226 -25.21290 6.61052   1.000 66.19874 ? 384 PRO B CA  1 
ATOM   740  C C   . PRO B 2 52  ? 14.61742 -24.07361 7.47405   1.000 74.88255 ? 384 PRO B C   1 
ATOM   741  O O   . PRO B 2 52  ? 15.22011 -22.99252 7.48910   1.000 75.19573 ? 384 PRO B O   1 
ATOM   742  C CB  . PRO B 2 52  ? 14.28529 -25.39868 5.34193   1.000 68.06192 ? 384 PRO B CB  1 
ATOM   743  C CG  . PRO B 2 52  ? 13.40961 -26.58483 5.62372   1.000 64.39801 ? 384 PRO B CG  1 
ATOM   744  C CD  . PRO B 2 52  ? 14.21328 -27.48073 6.50979   1.000 65.43433 ? 384 PRO B CD  1 
ATOM   745  N N   . THR B 2 53  ? 13.52219 -24.28700 8.20638   1.000 76.12383 ? 385 THR B N   1 
ATOM   746  C CA  . THR B 2 53  ? 12.91853 -23.20671 8.97857   1.000 76.40949 ? 385 THR B CA  1 
ATOM   747  C C   . THR B 2 53  ? 13.71660 -22.85793 10.22857  1.000 76.12211 ? 385 THR B C   1 
ATOM   748  O O   . THR B 2 53  ? 13.54169 -21.76241 10.77283  1.000 78.52687 ? 385 THR B O   1 
ATOM   749  C CB  . THR B 2 53  ? 11.48694 -23.57981 9.36788   1.000 80.16527 ? 385 THR B CB  1 
ATOM   750  O OG1 . THR B 2 53  ? 11.49986 -24.78196 10.14949  1.000 77.59787 ? 385 THR B OG1 1 
ATOM   751  C CG2 . THR B 2 53  ? 10.63975 -23.80011 8.12188   1.000 74.69139 ? 385 THR B CG2 1 
ATOM   752  N N   . LYS B 2 54  ? 14.58896 -23.75220 10.68860  1.000 75.26295 ? 386 LYS B N   1 
ATOM   753  C CA  . LYS B 2 54  ? 15.33209 -23.56295 11.92636  1.000 72.40638 ? 386 LYS B CA  1 
ATOM   754  C C   . LYS B 2 54  ? 16.74495 -23.03507 11.69977  1.000 73.34441 ? 386 LYS B C   1 
ATOM   755  O O   . LYS B 2 54  ? 17.55417 -23.04656 12.63328  1.000 70.76333 ? 386 LYS B O   1 
ATOM   756  C CB  . LYS B 2 54  ? 15.38865 -24.87924 12.70270  1.000 73.96403 ? 386 LYS B CB  1 
ATOM   757  C CG  . LYS B 2 54  ? 14.04732 -25.58669 12.80968  1.000 78.41404 ? 386 LYS B CG  1 
ATOM   758  C CD  . LYS B 2 54  ? 14.16817 -26.89123 13.58299  1.000 80.11860 ? 386 LYS B CD  1 
ATOM   759  C CE  . LYS B 2 54  ? 12.84140 -27.63359 13.62268  1.000 74.16603 ? 386 LYS B CE  1 
ATOM   760  N NZ  . LYS B 2 54  ? 12.95878 -28.94725 14.31225  1.000 71.49149 ? 386 LYS B NZ  1 
ATOM   761  N N   . LEU B 2 55  ? 17.05988 -22.57173 10.48582  1.000 76.25787 ? 387 LEU B N   1 
ATOM   762  C CA  . LEU B 2 55  ? 18.41549 -22.10914 10.20124  1.000 71.67328 ? 387 LEU B CA  1 
ATOM   763  C C   . LEU B 2 55  ? 18.78423 -20.88692 11.03077  1.000 69.10814 ? 387 LEU B C   1 
ATOM   764  O O   . LEU B 2 55  ? 19.95262 -20.71834 11.39752  1.000 69.69997 ? 387 LEU B O   1 
ATOM   765  C CB  . LEU B 2 55  ? 18.57149 -21.80450 8.71039   1.000 69.01871 ? 387 LEU B CB  1 
ATOM   766  C CG  . LEU B 2 55  ? 18.64833 -23.02019 7.78449   1.000 70.25588 ? 387 LEU B CG  1 
ATOM   767  C CD1 . LEU B 2 55  ? 18.89228 -22.58867 6.34584   1.000 67.97565 ? 387 LEU B CD1 1 
ATOM   768  C CD2 . LEU B 2 55  ? 19.73255 -23.98110 8.25514   1.000 67.73400 ? 387 LEU B CD2 1 
ATOM   769  N N   . ASN B 2 56  ? 17.81184 -20.02861 11.34361  1.000 67.09886 ? 388 ASN B N   1 
ATOM   770  C CA  . ASN B 2 56  ? 18.09800 -18.85920 12.16428  1.000 67.22023 ? 388 ASN B CA  1 
ATOM   771  C C   . ASN B 2 56  ? 18.45428 -19.21848 13.60148  1.000 68.82361 ? 388 ASN B C   1 
ATOM   772  O O   . ASN B 2 56  ? 18.90402 -18.34012 14.34425  1.000 67.14317 ? 388 ASN B O   1 
ATOM   773  C CB  . ASN B 2 56  ? 16.90655 -17.89935 12.14591  1.000 70.91682 ? 388 ASN B CB  1 
ATOM   774  C CG  . ASN B 2 56  ? 17.13591 -16.70310 11.23790  1.000 74.28659 ? 388 ASN B CG  1 
ATOM   775  O OD1 . ASN B 2 56  ? 18.16802 -16.60266 10.57331  1.000 71.43542 ? 388 ASN B OD1 1 
ATOM   776  N ND2 . ASN B 2 56  ? 16.17064 -15.78971 11.20400  1.000 76.39636 ? 388 ASN B ND2 1 
ATOM   777  N N   . ASP B 2 57  ? 18.27837 -20.47845 14.00515  1.000 67.84326 ? 389 ASP B N   1 
ATOM   778  C CA  . ASP B 2 57  ? 18.59381 -20.90921 15.36150  1.000 67.65100 ? 389 ASP B CA  1 
ATOM   779  C C   . ASP B 2 57  ? 19.98869 -21.50206 15.50189  1.000 68.68294 ? 389 ASP B C   1 
ATOM   780  O O   . ASP B 2 57  ? 20.51920 -21.53913 16.61846  1.000 69.61929 ? 389 ASP B O   1 
ATOM   781  C CB  . ASP B 2 57  ? 17.58149 -21.95660 15.83930  1.000 74.54297 ? 389 ASP B CB  1 
ATOM   782  C CG  . ASP B 2 57  ? 16.19483 -21.38396 16.04698  1.000 80.01402 ? 389 ASP B CG  1 
ATOM   783  O OD1 . ASP B 2 57  ? 16.08575 -20.19330 16.41351  1.000 78.57987 ? 389 ASP B OD1 1 
ATOM   784  O OD2 . ASP B 2 57  ? 15.21410 -22.13422 15.85088  1.000 78.41728 ? 389 ASP B OD2 1 
ATOM   785  N N   . LEU B 2 58  ? 20.59054 -21.96075 14.40930  1.000 68.70100 ? 390 LEU B N   1 
ATOM   786  C CA  . LEU B 2 58  ? 21.77537 -22.80276 14.47233  1.000 61.58624 ? 390 LEU B CA  1 
ATOM   787  C C   . LEU B 2 58  ? 23.06149 -21.98947 14.34620  1.000 57.27699 ? 390 LEU B C   1 
ATOM   788  O O   . LEU B 2 58  ? 23.06658 -20.83572 13.90782  1.000 56.35616 ? 390 LEU B O   1 
ATOM   789  C CB  . LEU B 2 58  ? 21.72658 -23.86445 13.37450  1.000 59.87648 ? 390 LEU B CB  1 
ATOM   790  C CG  . LEU B 2 58  ? 20.49039 -24.76256 13.35620  1.000 62.45189 ? 390 LEU B CG  1 
ATOM   791  C CD1 . LEU B 2 58  ? 20.08494 -25.05851 11.92225  1.000 68.46725 ? 390 LEU B CD1 1 
ATOM   792  C CD2 . LEU B 2 58  ? 20.76065 -26.05242 14.11268  1.000 58.77776 ? 390 LEU B CD2 1 
ATOM   793  N N   . CYS B 2 59  ? 24.16399 -22.62158 14.74606  1.000 54.94676 ? 391 CYS B N   1 
ATOM   794  C CA  . CYS B 2 59  ? 25.50248 -22.06833 14.61193  1.000 52.67783 ? 391 CYS B CA  1 
ATOM   795  C C   . CYS B 2 59  ? 26.39661 -23.09168 13.92510  1.000 47.72116 ? 391 CYS B C   1 
ATOM   796  O O   . CYS B 2 59  ? 26.26762 -24.29923 14.15068  1.000 47.57168 ? 391 CYS B O   1 
ATOM   797  C CB  . CYS B 2 59  ? 26.10099 -21.69311 15.97495  1.000 57.81873 ? 391 CYS B CB  1 
ATOM   798  S SG  . CYS B 2 59  ? 25.33066 -20.29418 16.82086  1.000 58.55142 ? 391 CYS B SG  1 
ATOM   799  N N   . PHE B 2 60  ? 27.30984 -22.60381 13.08604  1.000 44.80511 ? 392 PHE B N   1 
ATOM   800  C CA  . PHE B 2 60  ? 28.21582 -23.48507 12.36290  1.000 37.15876 ? 392 PHE B CA  1 
ATOM   801  C C   . PHE B 2 60  ? 29.61566 -22.88776 12.34601  1.000 37.62413 ? 392 PHE B C   1 
ATOM   802  O O   . PHE B 2 60  ? 29.80188 -21.67798 12.50206  1.000 40.06715 ? 392 PHE B O   1 
ATOM   803  C CB  . PHE B 2 60  ? 27.71316 -23.75404 10.93086  1.000 43.43112 ? 392 PHE B CB  1 
ATOM   804  C CG  . PHE B 2 60  ? 26.46419 -24.58844 10.88440  1.000 40.50004 ? 392 PHE B CG  1 
ATOM   805  C CD1 . PHE B 2 60  ? 26.53923 -25.97016 10.95470  1.000 38.94203 ? 392 PHE B CD1 1 
ATOM   806  C CD2 . PHE B 2 60  ? 25.21702 -23.99151 10.79684  1.000 42.95870 ? 392 PHE B CD2 1 
ATOM   807  C CE1 . PHE B 2 60  ? 25.39667 -26.74238 10.92867  1.000 40.57087 ? 392 PHE B CE1 1 
ATOM   808  C CE2 . PHE B 2 60  ? 24.06945 -24.75851 10.76915  1.000 44.93364 ? 392 PHE B CE2 1 
ATOM   809  C CZ  . PHE B 2 60  ? 24.16025 -26.13634 10.83561  1.000 43.24586 ? 392 PHE B CZ  1 
ATOM   810  N N   . THR B 2 61  ? 30.60652 -23.76771 12.16830  1.000 38.18544 ? 393 THR B N   1 
ATOM   811  C CA  . THR B 2 61  ? 31.99593 -23.32658 12.06933  1.000 38.66444 ? 393 THR B CA  1 
ATOM   812  C C   . THR B 2 61  ? 32.22090 -22.51914 10.79995  1.000 42.41195 ? 393 THR B C   1 
ATOM   813  O O   . THR B 2 61  ? 32.80408 -21.42819 10.83396  1.000 39.23303 ? 393 THR B O   1 
ATOM   814  C CB  . THR B 2 61  ? 32.93396 -24.53328 12.09484  1.000 41.98464 ? 393 THR B CB  1 
ATOM   815  O OG1 . THR B 2 61  ? 32.54638 -25.42453 13.14690  1.000 47.88230 ? 393 THR B OG1 1 
ATOM   816  C CG2 . THR B 2 61  ? 34.37364 -24.08459 12.32357  1.000 41.63276 ? 393 THR B CG2 1 
ATOM   817  N N   . ASN B 2 62  ? 31.77345 -23.05013 9.66549   1.000 41.95719 ? 394 ASN B N   1 
ATOM   818  C CA  . ASN B 2 62  ? 31.84428 -22.35578 8.39122   1.000 45.33069 ? 394 ASN B CA  1 
ATOM   819  C C   . ASN B 2 62  ? 30.57787 -22.63542 7.60076   1.000 37.72537 ? 394 ASN B C   1 
ATOM   820  O O   . ASN B 2 62  ? 29.92965 -23.67163 7.77402   1.000 36.93766 ? 394 ASN B O   1 
ATOM   821  C CB  . ASN B 2 62  ? 33.05543 -22.78587 7.54795   1.000 45.08351 ? 394 ASN B CB  1 
ATOM   822  C CG  . ASN B 2 62  ? 34.37248 -22.37363 8.16332   1.000 47.87200 ? 394 ASN B CG  1 
ATOM   823  O OD1 . ASN B 2 62  ? 34.75656 -21.20379 8.10944   1.000 47.29759 ? 394 ASN B OD1 1 
ATOM   824  N ND2 . ASN B 2 62  ? 35.08186 -23.33725 8.74080   1.000 42.82545 ? 394 ASN B ND2 1 
ATOM   825  N N   . VAL B 2 63  ? 30.23442 -21.69413 6.73193   1.000 38.45033 ? 395 VAL B N   1 
ATOM   826  C CA  . VAL B 2 63  ? 29.21934 -21.89311 5.70826   1.000 36.22133 ? 395 VAL B CA  1 
ATOM   827  C C   . VAL B 2 63  ? 29.87862 -21.62677 4.36432   1.000 34.33141 ? 395 VAL B C   1 
ATOM   828  O O   . VAL B 2 63  ? 30.53515 -20.59312 4.18466   1.000 37.86538 ? 395 VAL B O   1 
ATOM   829  C CB  . VAL B 2 63  ? 27.99871 -20.97850 5.92283   1.000 39.63574 ? 395 VAL B CB  1 
ATOM   830  C CG1 . VAL B 2 63  ? 27.07439 -21.02295 4.71904   1.000 35.21397 ? 395 VAL B CG1 1 
ATOM   831  C CG2 . VAL B 2 63  ? 27.24402 -21.39780 7.17220   1.000 36.26210 ? 395 VAL B CG2 1 
ATOM   832  N N   . TYR B 2 64  ? 29.73484 -22.56832 3.43648   1.000 35.09671 ? 396 TYR B N   1 
ATOM   833  C CA  . TYR B 2 64  ? 30.21353 -22.39746 2.06922   1.000 36.56197 ? 396 TYR B CA  1 
ATOM   834  C C   . TYR B 2 64  ? 29.01843 -22.24934 1.14535   1.000 32.99710 ? 396 TYR B C   1 
ATOM   835  O O   . TYR B 2 64  ? 28.09268 -23.06618 1.18731   1.000 35.12011 ? 396 TYR B O   1 
ATOM   836  C CB  . TYR B 2 64  ? 31.08309 -23.57507 1.62318   1.000 35.68671 ? 396 TYR B CB  1 
ATOM   837  C CG  . TYR B 2 64  ? 32.27334 -23.79548 2.52065   1.000 39.35596 ? 396 TYR B CG  1 
ATOM   838  C CD1 . TYR B 2 64  ? 33.43060 -23.04112 2.37143   1.000 43.13983 ? 396 TYR B CD1 1 
ATOM   839  C CD2 . TYR B 2 64  ? 32.23487 -24.74529 3.52797   1.000 46.34686 ? 396 TYR B CD2 1 
ATOM   840  C CE1 . TYR B 2 64  ? 34.51921 -23.23735 3.19843   1.000 48.28261 ? 396 TYR B CE1 1 
ATOM   841  C CE2 . TYR B 2 64  ? 33.31646 -24.94650 4.36142   1.000 46.56524 ? 396 TYR B CE2 1 
ATOM   842  C CZ  . TYR B 2 64  ? 34.45482 -24.18995 4.19333   1.000 50.87747 ? 396 TYR B CZ  1 
ATOM   843  O OH  . TYR B 2 64  ? 35.53090 -24.39386 5.02769   1.000 59.36148 ? 396 TYR B OH  1 
ATOM   844  N N   . ALA B 2 65  ? 29.03641 -21.20121 0.32931   1.000 32.92017 ? 397 ALA B N   1 
ATOM   845  C CA  . ALA B 2 65  ? 27.98786 -20.93805 -0.64865  1.000 36.48987 ? 397 ALA B CA  1 
ATOM   846  C C   . ALA B 2 65  ? 28.57008 -21.14773 -2.04158  1.000 31.51971 ? 397 ALA B C   1 
ATOM   847  O O   . ALA B 2 65  ? 29.42628 -20.37411 -2.48495  1.000 34.38610 ? 397 ALA B O   1 
ATOM   848  C CB  . ALA B 2 65  ? 27.43385 -19.52429 -0.48708  1.000 35.08120 ? 397 ALA B CB  1 
ATOM   849  N N   . ASP B 2 66  ? 28.11307 -22.19659 -2.72051  1.000 35.45415 ? 398 ASP B N   1 
ATOM   850  C CA  . ASP B 2 66  ? 28.47032 -22.46783 -4.10689  1.000 34.40800 ? 398 ASP B CA  1 
ATOM   851  C C   . ASP B 2 66  ? 27.35337 -21.97183 -5.02092  1.000 37.69341 ? 398 ASP B C   1 
ATOM   852  O O   . ASP B 2 66  ? 26.17047 -22.14295 -4.71271  1.000 35.74432 ? 398 ASP B O   1 
ATOM   853  C CB  . ASP B 2 66  ? 28.70666 -23.96740 -4.32373  1.000 30.57518 ? 398 ASP B CB  1 
ATOM   854  C CG  . ASP B 2 66  ? 29.82418 -24.52675 -3.44633  1.000 37.02959 ? 398 ASP B CG  1 
ATOM   855  O OD1 . ASP B 2 66  ? 30.68413 -23.74620 -2.98277  1.000 35.82650 ? 398 ASP B OD1 1 
ATOM   856  O OD2 . ASP B 2 66  ? 29.85256 -25.75746 -3.22939  1.000 36.12748 ? 398 ASP B OD2 1 
ATOM   857  N N   . SER B 2 67  ? 27.72200 -21.35432 -6.14706  1.000 33.58338 ? 399 SER B N   1 
ATOM   858  C CA  . SER B 2 67  ? 26.72670 -20.73764 -7.01168  1.000 29.32725 ? 399 SER B CA  1 
ATOM   859  C C   . SER B 2 67  ? 27.12914 -20.87087 -8.47692  1.000 35.00139 ? 399 SER B C   1 
ATOM   860  O O   . SER B 2 67  ? 28.31745 -20.85407 -8.81605  1.000 30.56649 ? 399 SER B O   1 
ATOM   861  C CB  . SER B 2 67  ? 26.51071 -19.25527 -6.65449  1.000 29.49155 ? 399 SER B CB  1 
ATOM   862  O OG  . SER B 2 67  ? 27.71557 -18.51858 -6.76462  1.000 32.71690 ? 399 SER B OG  1 
ATOM   863  N N   . PHE B 2 68  ? 26.12069 -20.99598 -9.33915  1.000 33.18223 ? 400 PHE B N   1 
ATOM   864  C CA  . PHE B 2 68  ? 26.31391 -21.23665 -10.76992 1.000 28.85309 ? 400 PHE B CA  1 
ATOM   865  C C   . PHE B 2 68  ? 24.95004 -21.21995 -11.46044 1.000 35.16152 ? 400 PHE B C   1 
ATOM   866  O O   . PHE B 2 68  ? 23.90583 -21.11201 -10.81099 1.000 36.55419 ? 400 PHE B O   1 
ATOM   867  C CB  . PHE B 2 68  ? 27.04079 -22.56136 -11.00985 1.000 31.66201 ? 400 PHE B CB  1 
ATOM   868  C CG  . PHE B 2 68  ? 26.40863 -23.73440 -10.31968 1.000 33.17149 ? 400 PHE B CG  1 
ATOM   869  C CD1 . PHE B 2 68  ? 25.36055 -24.41910 -10.90849 1.000 32.73288 ? 400 PHE B CD1 1 
ATOM   870  C CD2 . PHE B 2 68  ? 26.86302 -24.15408 -9.07513  1.000 32.78367 ? 400 PHE B CD2 1 
ATOM   871  C CE1 . PHE B 2 68  ? 24.77547 -25.50006 -10.27767 1.000 31.44528 ? 400 PHE B CE1 1 
ATOM   872  C CE2 . PHE B 2 68  ? 26.28223 -25.23450 -8.43614  1.000 33.51247 ? 400 PHE B CE2 1 
ATOM   873  C CZ  . PHE B 2 68  ? 25.23642 -25.90868 -9.03855  1.000 33.28230 ? 400 PHE B CZ  1 
ATOM   874  N N   . VAL B 2 69  ? 24.96626 -21.34125 -12.79229 1.000 30.61510 ? 401 VAL B N   1 
ATOM   875  C CA  . VAL B 2 69  ? 23.75543 -21.37678 -13.61003 1.000 34.86436 ? 401 VAL B CA  1 
ATOM   876  C C   . VAL B 2 69  ? 23.73427 -22.67349 -14.41503 1.000 34.90472 ? 401 VAL B C   1 
ATOM   877  O O   . VAL B 2 69  ? 24.76041 -23.08905 -14.96438 1.000 33.14284 ? 401 VAL B O   1 
ATOM   878  C CB  . VAL B 2 69  ? 23.66200 -20.15301 -14.55099 1.000 36.11575 ? 401 VAL B CB  1 
ATOM   879  C CG1 . VAL B 2 69  ? 22.60632 -20.37373 -15.63468 1.000 33.50709 ? 401 VAL B CG1 1 
ATOM   880  C CG2 . VAL B 2 69  ? 23.33123 -18.89766 -13.76941 1.000 36.97968 ? 401 VAL B CG2 1 
ATOM   881  N N   . ILE B 2 70  ? 22.56557 -23.32036 -14.46633 1.000 34.97049 ? 402 ILE B N   1 
ATOM   882  C CA  . ILE B 2 70  ? 22.31913 -24.49557 -15.29683 1.000 33.62988 ? 402 ILE B CA  1 
ATOM   883  C C   . ILE B 2 70  ? 20.94207 -24.35032 -15.94587 1.000 37.23841 ? 402 ILE B C   1 
ATOM   884  O O   . ILE B 2 70  ? 20.23220 -23.36504 -15.72967 1.000 34.18046 ? 402 ILE B O   1 
ATOM   885  C CB  . ILE B 2 70  ? 22.39250 -25.81308 -14.49737 1.000 35.76269 ? 402 ILE B CB  1 
ATOM   886  C CG1 . ILE B 2 70  ? 21.58466 -25.70386 -13.19712 1.000 33.31793 ? 402 ILE B CG1 1 
ATOM   887  C CG2 . ILE B 2 70  ? 23.84176 -26.19686 -14.20766 1.000 34.66660 ? 402 ILE B CG2 1 
ATOM   888  C CD1 . ILE B 2 70  ? 21.60086 -26.96699 -12.37133 1.000 29.18533 ? 402 ILE B CD1 1 
ATOM   889  N N   . ARG B 2 71  ? 20.57891 -25.34602 -16.75430 1.000 35.98925 ? 403 ARG B N   1 
ATOM   890  C CA  . ARG B 2 71  ? 19.23339 -25.43060 -17.30840 1.000 36.09473 ? 403 ARG B CA  1 
ATOM   891  C C   . ARG B 2 71  ? 18.24144 -25.89349 -16.24760 1.000 37.13585 ? 403 ARG B C   1 
ATOM   892  O O   . ARG B 2 71  ? 18.58861 -26.63352 -15.32198 1.000 37.00530 ? 403 ARG B O   1 
ATOM   893  C CB  . ARG B 2 71  ? 19.19395 -26.40592 -18.48817 1.000 35.82905 ? 403 ARG B CB  1 
ATOM   894  C CG  . ARG B 2 71  ? 19.87055 -25.91213 -19.74242 1.000 35.31374 ? 403 ARG B CG  1 
ATOM   895  C CD  . ARG B 2 71  ? 20.32913 -27.07256 -20.62824 1.000 38.35283 ? 403 ARG B CD  1 
ATOM   896  N NE  . ARG B 2 71  ? 19.30336 -28.08759 -20.84937 1.000 37.82220 ? 403 ARG B NE  1 
ATOM   897  C CZ  . ARG B 2 71  ? 19.48511 -29.17754 -21.58469 1.000 38.72920 ? 403 ARG B CZ  1 
ATOM   898  N NH1 . ARG B 2 71  ? 20.63668 -29.41707 -22.18904 1.000 36.07596 ? 403 ARG B NH1 1 
ATOM   899  N NH2 . ARG B 2 71  ? 18.48783 -30.04901 -21.71736 1.000 34.57956 ? 403 ARG B NH2 1 
ATOM   900  N N   . GLY B 2 72  ? 16.98467 -25.46452 -16.40878 1.000 37.35945 ? 404 GLY B N   1 
ATOM   901  C CA  . GLY B 2 72  ? 15.93969 -25.88839 -15.48911 1.000 39.28343 ? 404 GLY B CA  1 
ATOM   902  C C   . GLY B 2 72  ? 15.86741 -27.39443 -15.32200 1.000 38.62633 ? 404 GLY B C   1 
ATOM   903  O O   . GLY B 2 72  ? 15.75732 -27.89991 -14.20107 1.000 38.51075 ? 404 GLY B O   1 
ATOM   904  N N   . ASN B 2 73  ? 15.95101 -28.13492 -16.42898 1.000 34.92789 ? 405 ASN B N   1 
ATOM   905  C CA  . ASN B 2 73  ? 15.85610 -29.58877 -16.35769 1.000 33.90847 ? 405 ASN B CA  1 
ATOM   906  C C   . ASN B 2 73  ? 17.04355 -30.22590 -15.64601 1.000 38.14975 ? 405 ASN B C   1 
ATOM   907  O O   . ASN B 2 73  ? 16.96464 -31.40430 -15.28026 1.000 38.64317 ? 405 ASN B O   1 
ATOM   908  C CB  . ASN B 2 73  ? 15.72206 -30.17365 -17.76632 1.000 41.18922 ? 405 ASN B CB  1 
ATOM   909  C CG  . ASN B 2 73  ? 17.02382 -30.14628 -18.52947 1.000 34.90083 ? 405 ASN B CG  1 
ATOM   910  O OD1 . ASN B 2 73  ? 17.50000 -29.08338 -18.92841 1.000 36.91458 ? 405 ASN B OD1 1 
ATOM   911  N ND2 . ASN B 2 73  ? 17.61132 -31.31902 -18.73874 1.000 34.48966 ? 405 ASN B ND2 1 
ATOM   912  N N   . GLU B 2 74  ? 18.13211 -29.48364 -15.43914 1.000 34.35054 ? 406 GLU B N   1 
ATOM   913  C CA  . GLU B 2 74  ? 19.32252 -30.00761 -14.78435 1.000 30.64857 ? 406 GLU B CA  1 
ATOM   914  C C   . GLU B 2 74  ? 19.34047 -29.74418 -13.28126 1.000 33.73356 ? 406 GLU B C   1 
ATOM   915  O O   . GLU B 2 74  ? 20.14372 -30.36031 -12.57072 1.000 34.57552 ? 406 GLU B O   1 
ATOM   916  C CB  . GLU B 2 74  ? 20.57942 -29.41063 -15.43758 1.000 30.63777 ? 406 GLU B CB  1 
ATOM   917  C CG  . GLU B 2 74  ? 20.73404 -29.81926 -16.91031 1.000 28.92921 ? 406 GLU B CG  1 
ATOM   918  C CD  . GLU B 2 74  ? 21.78127 -29.01721 -17.67030 1.000 34.81866 ? 406 GLU B CD  1 
ATOM   919  O OE1 . GLU B 2 74  ? 22.08592 -27.87586 -17.26391 1.000 30.71423 ? 406 GLU B OE1 1 
ATOM   920  O OE2 . GLU B 2 74  ? 22.28530 -29.52866 -18.69940 1.000 38.79647 ? 406 GLU B OE2 1 
ATOM   921  N N   . VAL B 2 75  ? 18.46418 -28.86435 -12.78537 1.000 33.48476 ? 407 VAL B N   1 
ATOM   922  C CA  . VAL B 2 75  ? 18.41939 -28.53810 -11.35807 1.000 32.87117 ? 407 VAL B CA  1 
ATOM   923  C C   . VAL B 2 75  ? 18.27143 -29.78816 -10.50095 1.000 37.44507 ? 407 VAL B C   1 
ATOM   924  O O   . VAL B 2 75  ? 18.82346 -29.86295 -9.39307  1.000 36.58053 ? 407 VAL B O   1 
ATOM   925  C CB  . VAL B 2 75  ? 17.28073 -27.53464 -11.08740 1.000 33.20375 ? 407 VAL B CB  1 
ATOM   926  C CG1 . VAL B 2 75  ? 17.06491 -27.34764 -9.57516  1.000 32.21417 ? 407 VAL B CG1 1 
ATOM   927  C CG2 . VAL B 2 75  ? 17.57875 -26.20272 -11.74705 1.000 33.42692 ? 407 VAL B CG2 1 
ATOM   928  N N   . SER B 2 76  ? 17.54206 -30.79176 -10.99128 1.000 39.03057 ? 408 SER B N   1 
ATOM   929  C CA  . SER B 2 76  ? 17.32674 -32.00110 -10.20602 1.000 37.71266 ? 408 SER B CA  1 
ATOM   930  C C   . SER B 2 76  ? 18.60093 -32.81362 -10.01915 1.000 40.14843 ? 408 SER B C   1 
ATOM   931  O O   . SER B 2 76  ? 18.63977 -33.68166 -9.14144  1.000 41.42028 ? 408 SER B O   1 
ATOM   932  C CB  . SER B 2 76  ? 16.24412 -32.86525 -10.85602 1.000 42.73624 ? 408 SER B CB  1 
ATOM   933  O OG  . SER B 2 76  ? 16.60883 -33.22682 -12.17218 1.000 40.87866 ? 408 SER B OG  1 
ATOM   934  N N   . GLN B 2 77  ? 19.64156 -32.55601 -10.81409 1.000 33.38125 ? 409 GLN B N   1 
ATOM   935  C CA  . GLN B 2 77  ? 20.91546 -33.23183 -10.60688 1.000 34.53858 ? 409 GLN B CA  1 
ATOM   936  C C   . GLN B 2 77  ? 21.70153 -32.66147 -9.43437  1.000 35.11069 ? 409 GLN B C   1 
ATOM   937  O O   . GLN B 2 77  ? 22.67247 -33.28687 -8.99888  1.000 33.68276 ? 409 GLN B O   1 
ATOM   938  C CB  . GLN B 2 77  ? 21.77626 -33.15405 -11.86479 1.000 33.89295 ? 409 GLN B CB  1 
ATOM   939  C CG  . GLN B 2 77  ? 21.12493 -33.74090 -13.10146 1.000 32.03567 ? 409 GLN B CG  1 
ATOM   940  C CD  . GLN B 2 77  ? 22.04526 -33.69129 -14.30041 1.000 35.30913 ? 409 GLN B CD  1 
ATOM   941  O OE1 . GLN B 2 77  ? 23.24966 -33.91545 -14.17742 1.000 35.06193 ? 409 GLN B OE1 1 
ATOM   942  N NE2 . GLN B 2 77  ? 21.48535 -33.39216 -15.46824 1.000 34.21177 ? 409 GLN B NE2 1 
ATOM   943  N N   . ILE B 2 78  ? 21.32674 -31.48697 -8.93157  1.000 32.35491 ? 410 ILE B N   1 
ATOM   944  C CA  . ILE B 2 78  ? 22.02998 -30.89260 -7.80028  1.000 34.48982 ? 410 ILE B CA  1 
ATOM   945  C C   . ILE B 2 78  ? 21.45400 -31.47911 -6.51804  1.000 38.39749 ? 410 ILE B C   1 
ATOM   946  O O   . ILE B 2 78  ? 20.74651 -30.80026 -5.76564  1.000 36.36702 ? 410 ILE B O   1 
ATOM   947  C CB  . ILE B 2 78  ? 21.93744 -29.35586 -7.82324  1.000 32.45693 ? 410 ILE B CB  1 
ATOM   948  C CG1 . ILE B 2 78  ? 22.18717 -28.83504 -9.24022  1.000 35.38528 ? 410 ILE B CG1 1 
ATOM   949  C CG2 . ILE B 2 78  ? 22.96429 -28.74399 -6.87643  1.000 34.57380 ? 410 ILE B CG2 1 
ATOM   950  C CD1 . ILE B 2 78  ? 23.51546 -29.27202 -9.82734  1.000 30.62939 ? 410 ILE B CD1 1 
ATOM   951  N N   . ALA B 2 79  ? 21.75530 -32.75243 -6.27071  1.000 39.34098 ? 411 ALA B N   1 
ATOM   952  C CA  . ALA B 2 79  ? 21.23881 -33.48857 -5.12654  1.000 40.53808 ? 411 ALA B CA  1 
ATOM   953  C C   . ALA B 2 79  ? 22.12632 -34.70157 -4.91752  1.000 40.08952 ? 411 ALA B C   1 
ATOM   954  O O   . ALA B 2 79  ? 22.72135 -35.19461 -5.88225  1.000 40.38187 ? 411 ALA B O   1 
ATOM   955  C CB  . ALA B 2 79  ? 19.78248 -33.91912 -5.35716  1.000 41.39128 ? 411 ALA B CB  1 
ATOM   956  N N   . PRO B 2 80  ? 22.25445 -35.19519 -3.68579  1.000 44.35202 ? 412 PRO B N   1 
ATOM   957  C CA  . PRO B 2 80  ? 23.11073 -36.36416 -3.45769  1.000 41.55337 ? 412 PRO B CA  1 
ATOM   958  C C   . PRO B 2 80  ? 22.61104 -37.57436 -4.22939  1.000 41.14736 ? 412 PRO B C   1 
ATOM   959  O O   . PRO B 2 80  ? 21.41029 -37.75084 -4.44369  1.000 47.36792 ? 412 PRO B O   1 
ATOM   960  C CB  . PRO B 2 80  ? 23.01715 -36.58629 -1.94358  1.000 45.26013 ? 412 PRO B CB  1 
ATOM   961  C CG  . PRO B 2 80  ? 22.64370 -35.25298 -1.39293  1.000 46.58427 ? 412 PRO B CG  1 
ATOM   962  C CD  . PRO B 2 80  ? 21.75082 -34.62607 -2.42358  1.000 43.83844 ? 412 PRO B CD  1 
ATOM   963  N N   . GLY B 2 81  ? 23.55721 -38.40456 -4.66402  1.000 42.38300 ? 413 GLY B N   1 
ATOM   964  C CA  . GLY B 2 81  ? 23.22843 -39.63210 -5.36096  1.000 44.18883 ? 413 GLY B CA  1 
ATOM   965  C C   . GLY B 2 81  ? 22.69863 -39.47280 -6.76760  1.000 46.39392 ? 413 GLY B C   1 
ATOM   966  O O   . GLY B 2 81  ? 22.16095 -40.43804 -7.31690  1.000 47.27231 ? 413 GLY B O   1 
ATOM   967  N N   . GLN B 2 82  ? 22.83243 -38.29541 -7.37265  1.000 46.31391 ? 414 GLN B N   1 
ATOM   968  C CA  . GLN B 2 82  ? 22.33945 -38.05863 -8.72425  1.000 44.53683 ? 414 GLN B CA  1 
ATOM   969  C C   . GLN B 2 82  ? 23.43739 -38.27188 -9.75799  1.000 45.75686 ? 414 GLN B C   1 
ATOM   970  O O   . GLN B 2 82  ? 24.62005 -38.04854 -9.49163  1.000 45.84258 ? 414 GLN B O   1 
ATOM   971  C CB  . GLN B 2 82  ? 21.78761 -36.63823 -8.85787  1.000 42.74957 ? 414 GLN B CB  1 
ATOM   972  C CG  . GLN B 2 82  ? 20.40240 -36.45314 -8.27076  1.000 46.62955 ? 414 GLN B CG  1 
ATOM   973  C CD  . GLN B 2 82  ? 19.33678 -37.16818 -9.07903  1.000 49.57114 ? 414 GLN B CD  1 
ATOM   974  O OE1 . GLN B 2 82  ? 19.33421 -37.11225 -10.30944 1.000 54.29758 ? 414 GLN B OE1 1 
ATOM   975  N NE2 . GLN B 2 82  ? 18.43001 -37.85259 -8.39086  1.000 50.47223 ? 414 GLN B NE2 1 
ATOM   976  N N   . THR B 2 83  ? 23.02974 -38.70215 -10.95181 1.000 48.44778 ? 415 THR B N   1 
ATOM   977  C CA  . THR B 2 83  ? 23.91453 -38.79844 -12.10287 1.000 50.27827 ? 415 THR B CA  1 
ATOM   978  C C   . THR B 2 83  ? 23.33325 -37.99889 -13.26201 1.000 46.55316 ? 415 THR B C   1 
ATOM   979  O O   . THR B 2 83  ? 22.14465 -37.66777 -13.28401 1.000 48.08986 ? 415 THR B O   1 
ATOM   980  C CB  . THR B 2 83  ? 24.13621 -40.25327 -12.54483 1.000 50.88165 ? 415 THR B CB  1 
ATOM   981  O OG1 . THR B 2 83  ? 22.91069 -40.79450 -13.05444 1.000 58.34277 ? 415 THR B OG1 1 
ATOM   982  C CG2 . THR B 2 83  ? 24.62813 -41.10492 -11.37913 1.000 53.84191 ? 415 THR B CG2 1 
ATOM   983  N N   . GLY B 2 84  ? 24.19093 -37.69200 -14.22917 1.000 43.01532 ? 416 GLY B N   1 
ATOM   984  C CA  . GLY B 2 84  ? 23.80317 -36.88486 -15.36961 1.000 43.38596 ? 416 GLY B CA  1 
ATOM   985  C C   . GLY B 2 84  ? 24.95290 -36.01874 -15.83956 1.000 39.62900 ? 416 GLY B C   1 
ATOM   986  O O   . GLY B 2 84  ? 26.02281 -36.03499 -15.22529 1.000 37.51571 ? 416 GLY B O   1 
ATOM   987  N N   . ASN B 2 85  ? 24.75002 -35.24596 -16.90997 1.000 37.25380 ? 417 ASN B N   1 
ATOM   988  C CA  . ASN B 2 85  ? 25.85430 -34.47332 -17.47465 1.000 35.62223 ? 417 ASN B CA  1 
ATOM   989  C C   . ASN B 2 85  ? 26.40259 -33.45310 -16.48213 1.000 37.82999 ? 417 ASN B C   1 
ATOM   990  O O   . ASN B 2 85  ? 27.59694 -33.13141 -16.52110 1.000 35.26605 ? 417 ASN B O   1 
ATOM   991  C CB  . ASN B 2 85  ? 25.40997 -33.77326 -18.76069 1.000 31.70119 ? 417 ASN B CB  1 
ATOM   992  C CG  . ASN B 2 85  ? 24.32223 -32.74967 -18.51712 1.000 35.65797 ? 417 ASN B CG  1 
ATOM   993  O OD1 . ASN B 2 85  ? 23.35786 -33.01301 -17.79458 1.000 36.20521 ? 417 ASN B OD1 1 
ATOM   994  N ND2 . ASN B 2 85  ? 24.47568 -31.56983 -19.10632 1.000 33.80964 ? 417 ASN B ND2 1 
ATOM   995  N N   . ILE B 2 86  ? 25.55897 -32.93784 -15.59171 1.000 32.53072 ? 418 ILE B N   1 
ATOM   996  C CA  . ILE B 2 86  ? 25.99323 -31.93592 -14.62054 1.000 33.49783 ? 418 ILE B CA  1 
ATOM   997  C C   . ILE B 2 86  ? 26.58149 -32.58888 -13.37679 1.000 35.47029 ? 418 ILE B C   1 
ATOM   998  O O   . ILE B 2 86  ? 27.65956 -32.20940 -12.90970 1.000 37.95082 ? 418 ILE B O   1 
ATOM   999  C CB  . ILE B 2 86  ? 24.81909 -30.99847 -14.26260 1.000 33.87795 ? 418 ILE B CB  1 
ATOM   1000 C CG1 . ILE B 2 86  ? 24.34352 -30.23737 -15.50214 1.000 34.57276 ? 418 ILE B CG1 1 
ATOM   1001 C CG2 . ILE B 2 86  ? 25.21988 -30.04021 -13.15230 1.000 35.22520 ? 418 ILE B CG2 1 
ATOM   1002 C CD1 . ILE B 2 86  ? 25.42592 -29.40757 -16.17312 1.000 33.13020 ? 418 ILE B CD1 1 
ATOM   1003 N N   . ALA B 2 87  ? 25.89223 -33.58566 -12.82007 1.000 34.32264 ? 419 ALA B N   1 
ATOM   1004 C CA  . ALA B 2 87  ? 26.42221 -34.25915 -11.63723 1.000 38.44910 ? 419 ALA B CA  1 
ATOM   1005 C C   . ALA B 2 87  ? 27.71812 -34.99757 -11.94524 1.000 39.92495 ? 419 ALA B C   1 
ATOM   1006 O O   . ALA B 2 87  ? 28.59441 -35.09204 -11.08024 1.000 36.12809 ? 419 ALA B O   1 
ATOM   1007 C CB  . ALA B 2 87  ? 25.38746 -35.22636 -11.06554 1.000 37.35804 ? 419 ALA B CB  1 
ATOM   1008 N N   . ASP B 2 88  ? 27.86668 -35.51026 -13.16868 1.000 38.84290 ? 420 ASP B N   1 
ATOM   1009 C CA  . ASP B 2 88  ? 29.05623 -36.28848 -13.50206 1.000 40.61879 ? 420 ASP B CA  1 
ATOM   1010 C C   . ASP B 2 88  ? 30.23846 -35.39498 -13.85913 1.000 38.84988 ? 420 ASP B C   1 
ATOM   1011 O O   . ASP B 2 88  ? 31.36012 -35.62608 -13.39495 1.000 41.10383 ? 420 ASP B O   1 
ATOM   1012 C CB  . ASP B 2 88  ? 28.76129 -37.24753 -14.65938 1.000 41.51505 ? 420 ASP B CB  1 
ATOM   1013 C CG  . ASP B 2 88  ? 27.79708 -38.35430 -14.27612 1.000 44.52493 ? 420 ASP B CG  1 
ATOM   1014 O OD1 . ASP B 2 88  ? 27.35474 -38.39956 -13.10934 1.000 43.10189 ? 420 ASP B OD1 1 
ATOM   1015 O OD2 . ASP B 2 88  ? 27.48934 -39.18564 -15.15217 1.000 46.16594 ? 420 ASP B OD2 1 
ATOM   1016 N N   . TYR B 2 89  ? 30.01292 -34.38134 -14.69510 1.000 33.79305 ? 421 TYR B N   1 
ATOM   1017 C CA  . TYR B 2 89  ? 31.10395 -33.66366 -15.33554 1.000 27.35156 ? 421 TYR B CA  1 
ATOM   1018 C C   . TYR B 2 89  ? 31.22315 -32.20574 -14.91468 1.000 34.15097 ? 421 TYR B C   1 
ATOM   1019 O O   . TYR B 2 89  ? 32.15723 -31.53434 -15.36318 1.000 32.42918 ? 421 TYR B O   1 
ATOM   1020 C CB  . TYR B 2 89  ? 30.95631 -33.72805 -16.87087 1.000 31.44721 ? 421 TYR B CB  1 
ATOM   1021 C CG  . TYR B 2 89  ? 30.91713 -35.11583 -17.48522 1.000 33.25612 ? 421 TYR B CG  1 
ATOM   1022 C CD1 . TYR B 2 89  ? 31.46075 -36.21434 -16.83419 1.000 35.09496 ? 421 TYR B CD1 1 
ATOM   1023 C CD2 . TYR B 2 89  ? 30.34349 -35.31841 -18.74204 1.000 36.72727 ? 421 TYR B CD2 1 
ATOM   1024 C CE1 . TYR B 2 89  ? 31.42272 -37.47823 -17.40193 1.000 39.05482 ? 421 TYR B CE1 1 
ATOM   1025 C CE2 . TYR B 2 89  ? 30.30243 -36.57601 -19.31684 1.000 38.91513 ? 421 TYR B CE2 1 
ATOM   1026 C CZ  . TYR B 2 89  ? 30.84291 -37.65097 -18.64716 1.000 43.70024 ? 421 TYR B CZ  1 
ATOM   1027 O OH  . TYR B 2 89  ? 30.79815 -38.90210 -19.22085 1.000 45.05055 ? 421 TYR B OH  1 
ATOM   1028 N N   . ASN B 2 90  ? 30.32352 -31.69168 -14.06886 1.000 32.07029 ? 422 ASN B N   1 
ATOM   1029 C CA  . ASN B 2 90  ? 30.33738 -30.26309 -13.75760 1.000 30.09018 ? 422 ASN B CA  1 
ATOM   1030 C C   . ASN B 2 90  ? 30.31265 -29.95109 -12.26074 1.000 29.22902 ? 422 ASN B C   1 
ATOM   1031 O O   . ASN B 2 90  ? 31.22808 -29.29240 -11.75876 1.000 31.18105 ? 422 ASN B O   1 
ATOM   1032 C CB  . ASN B 2 90  ? 29.16851 -29.56832 -14.45276 1.000 26.68112 ? 422 ASN B CB  1 
ATOM   1033 C CG  . ASN B 2 90  ? 29.33876 -29.53136 -15.96136 1.000 31.83499 ? 422 ASN B CG  1 
ATOM   1034 O OD1 . ASN B 2 90  ? 29.88173 -28.57119 -16.51037 1.000 30.75446 ? 422 ASN B OD1 1 
ATOM   1035 N ND2 . ASN B 2 90  ? 28.88921 -30.58276 -16.63558 1.000 29.64804 ? 422 ASN B ND2 1 
ATOM   1036 N N   . TYR B 2 91  ? 29.27471 -30.37817 -11.54333 1.000 30.75700 ? 423 TYR B N   1 
ATOM   1037 C CA  . TYR B 2 91  ? 29.17136 -30.11984 -10.10404 1.000 29.21945 ? 423 TYR B CA  1 
ATOM   1038 C C   . TYR B 2 91  ? 28.55771 -31.33610 -9.43031  1.000 35.57773 ? 423 TYR B C   1 
ATOM   1039 O O   . TYR B 2 91  ? 27.44765 -31.74302 -9.78585  1.000 33.47668 ? 423 TYR B O   1 
ATOM   1040 C CB  . TYR B 2 91  ? 28.33529 -28.86584 -9.81761  1.000 29.64996 ? 423 TYR B CB  1 
ATOM   1041 C CG  . TYR B 2 91  ? 28.28254 -28.47084 -8.34557  1.000 31.41536 ? 423 TYR B CG  1 
ATOM   1042 C CD1 . TYR B 2 91  ? 29.27848 -27.68113 -7.78048  1.000 32.25267 ? 423 TYR B CD1 1 
ATOM   1043 C CD2 . TYR B 2 91  ? 27.23314 -28.88128 -7.53248  1.000 28.65995 ? 423 TYR B CD2 1 
ATOM   1044 C CE1 . TYR B 2 91  ? 29.23362 -27.31436 -6.43305  1.000 31.62113 ? 423 TYR B CE1 1 
ATOM   1045 C CE2 . TYR B 2 91  ? 27.17818 -28.51951 -6.18402  1.000 33.97883 ? 423 TYR B CE2 1 
ATOM   1046 C CZ  . TYR B 2 91  ? 28.18150 -27.73845 -5.64544  1.000 32.34329 ? 423 TYR B CZ  1 
ATOM   1047 O OH  . TYR B 2 91  ? 28.13023 -27.37997 -4.31768  1.000 36.04780 ? 423 TYR B OH  1 
ATOM   1048 N N   . LYS B 2 92  ? 29.26193 -31.88980 -8.43654  1.000 36.69412 ? 424 LYS B N   1 
ATOM   1049 C CA  . LYS B 2 92  ? 28.90735 -33.15828 -7.80985  1.000 34.82846 ? 424 LYS B CA  1 
ATOM   1050 C C   . LYS B 2 92  ? 28.78377 -32.98536 -6.30178  1.000 34.01235 ? 424 LYS B C   1 
ATOM   1051 O O   . LYS B 2 92  ? 29.73017 -32.53526 -5.64702  1.000 34.76286 ? 424 LYS B O   1 
ATOM   1052 C CB  . LYS B 2 92  ? 29.95752 -34.23182 -8.12649  1.000 33.88622 ? 424 LYS B CB  1 
ATOM   1053 C CG  . LYS B 2 92  ? 29.72970 -35.56218 -7.42110  1.000 38.46240 ? 424 LYS B CG  1 
ATOM   1054 C CD  . LYS B 2 92  ? 28.33496 -36.08642 -7.69720  1.000 41.13060 ? 424 LYS B CD  1 
ATOM   1055 C CE  . LYS B 2 92  ? 28.15138 -37.51269 -7.22240  1.000 38.21488 ? 424 LYS B CE  1 
ATOM   1056 N NZ  . LYS B 2 92  ? 26.79354 -38.00715 -7.58578  1.000 45.80512 ? 424 LYS B NZ  1 
ATOM   1057 N N   . LEU B 2 93  ? 27.58632 -33.37075 -5.73301  1.000 38.71777 ? 425 LEU B N   1 
ATOM   1058 C CA  . LEU B 2 93  ? 27.41320 -33.34750 -4.28338  1.000 36.46281 ? 425 LEU B CA  1 
ATOM   1059 C C   . LEU B 2 93  ? 27.71998 -34.71500 -3.67905  1.000 41.95599 ? 425 LEU B C   1 
ATOM   1060 O O   . LEU B 2 93  ? 27.46551 -35.74881 -4.30385  1.000 40.40698 ? 425 LEU B O   1 
ATOM   1061 C CB  . LEU B 2 93  ? 25.98517 -32.94715 -3.91737  1.000 36.79063 ? 425 LEU B CB  1 
ATOM   1062 C CG  . LEU B 2 93  ? 25.57387 -31.48213 -4.05546  1.000 40.27755 ? 425 LEU B CG  1 
ATOM   1063 C CD1 . LEU B 2 93  ? 24.11378 -31.31391 -3.66203  1.000 37.76980 ? 425 LEU B CD1 1 
ATOM   1064 C CD2 . LEU B 2 93  ? 26.46230 -30.58545 -3.20817  1.000 38.72337 ? 425 LEU B CD2 1 
ATOM   1065 N N   . PRO B 2 94  ? 28.25770 -34.75433 -2.46265  1.000 43.40850 ? 426 PRO B N   1 
ATOM   1066 C CA  . PRO B 2 94  ? 28.52180 -36.03925 -1.80995  1.000 46.54486 ? 426 PRO B CA  1 
ATOM   1067 C C   . PRO B 2 94  ? 27.24499 -36.68653 -1.29243  1.000 50.98841 ? 426 PRO B C   1 
ATOM   1068 O O   . PRO B 2 94  ? 26.20266 -36.04765 -1.13513  1.000 49.73600 ? 426 PRO B O   1 
ATOM   1069 C CB  . PRO B 2 94  ? 29.44524 -35.65715 -0.65062  1.000 51.35400 ? 426 PRO B CB  1 
ATOM   1070 C CG  . PRO B 2 94  ? 29.01476 -34.26680 -0.30254  1.000 46.91896 ? 426 PRO B CG  1 
ATOM   1071 C CD  . PRO B 2 94  ? 28.68374 -33.61727 -1.62746  1.000 41.89668 ? 426 PRO B CD  1 
ATOM   1072 N N   . ASP B 2 95  ? 27.34933 -37.98920 -1.01888  1.000 54.08945 ? 427 ASP B N   1 
ATOM   1073 C CA  . ASP B 2 95  ? 26.21608 -38.71200 -0.44760  1.000 57.94011 ? 427 ASP B CA  1 
ATOM   1074 C C   . ASP B 2 95  ? 25.84846 -38.17106 0.93064   1.000 55.82383 ? 427 ASP B C   1 
ATOM   1075 O O   . ASP B 2 95  ? 24.66251 -38.07095 1.26576   1.000 60.94141 ? 427 ASP B O   1 
ATOM   1076 C CB  . ASP B 2 95  ? 26.52620 -40.20853 -0.37287  1.000 57.43580 ? 427 ASP B CB  1 
ATOM   1077 C CG  . ASP B 2 95  ? 26.77358 -40.82342 -1.73843  1.000 61.59793 ? 427 ASP B CG  1 
ATOM   1078 O OD1 . ASP B 2 95  ? 26.33108 -40.23347 -2.74708  1.000 57.85720 ? 427 ASP B OD1 1 
ATOM   1079 O OD2 . ASP B 2 95  ? 27.40723 -41.89830 -1.80395  1.000 65.37031 ? 427 ASP B OD2 1 
ATOM   1080 N N   . ASP B 2 96  ? 26.84659 -37.80524 1.74085   1.000 55.64698 ? 428 ASP B N   1 
ATOM   1081 C CA  . ASP B 2 96  ? 26.61082 -37.31630 3.09600   1.000 56.55249 ? 428 ASP B CA  1 
ATOM   1082 C C   . ASP B 2 96  ? 26.46951 -35.79837 3.16060   1.000 57.30047 ? 428 ASP B C   1 
ATOM   1083 O O   . ASP B 2 96  ? 26.85536 -35.18536 4.16616   1.000 51.01873 ? 428 ASP B O   1 
ATOM   1084 C CB  . ASP B 2 96  ? 27.72761 -37.79007 4.03035   1.000 58.99084 ? 428 ASP B CB  1 
ATOM   1085 C CG  . ASP B 2 96  ? 29.09832 -37.25617 3.63513   1.000 62.19303 ? 428 ASP B CG  1 
ATOM   1086 O OD1 . ASP B 2 96  ? 29.23117 -36.66987 2.53867   1.000 57.35409 ? 428 ASP B OD1 1 
ATOM   1087 O OD2 . ASP B 2 96  ? 30.04792 -37.42268 4.43095   1.000 63.85309 ? 428 ASP B OD2 1 
ATOM   1088 N N   . PHE B 2 97  ? 25.92138 -35.17967 2.11588   1.000 51.38753 ? 429 PHE B N   1 
ATOM   1089 C CA  . PHE B 2 97  ? 25.83312 -33.72545 2.05137   1.000 48.88978 ? 429 PHE B CA  1 
ATOM   1090 C C   . PHE B 2 97  ? 24.98900 -33.17294 3.19650   1.000 47.40065 ? 429 PHE B C   1 
ATOM   1091 O O   . PHE B 2 97  ? 23.88195 -33.65450 3.46071   1.000 49.01804 ? 429 PHE B O   1 
ATOM   1092 C CB  . PHE B 2 97  ? 25.24973 -33.30699 0.69482   1.000 40.69451 ? 429 PHE B CB  1 
ATOM   1093 C CG  . PHE B 2 97  ? 24.97543 -31.83662 0.57796   1.000 37.00758 ? 429 PHE B CG  1 
ATOM   1094 C CD1 . PHE B 2 97  ? 26.01498 -30.92077 0.59418   1.000 37.26322 ? 429 PHE B CD1 1 
ATOM   1095 C CD2 . PHE B 2 97  ? 23.67802 -31.36928 0.45367   1.000 36.10948 ? 429 PHE B CD2 1 
ATOM   1096 C CE1 . PHE B 2 97  ? 25.76288 -29.56122 0.48993   1.000 37.64262 ? 429 PHE B CE1 1 
ATOM   1097 C CE2 . PHE B 2 97  ? 23.41935 -30.01460 0.35069   1.000 32.78904 ? 429 PHE B CE2 1 
ATOM   1098 C CZ  . PHE B 2 97  ? 24.46271 -29.10990 0.36496   1.000 34.84810 ? 429 PHE B CZ  1 
ATOM   1099 N N   . THR B 2 98  ? 25.52761 -32.16844 3.89192   1.000 46.42111 ? 430 THR B N   1 
ATOM   1100 C CA  . THR B 2 98  ? 24.80643 -31.45061 4.94193   1.000 44.81783 ? 430 THR B CA  1 
ATOM   1101 C C   . THR B 2 98  ? 24.67715 -29.99221 4.51535   1.000 44.33643 ? 430 THR B C   1 
ATOM   1102 O O   . THR B 2 98  ? 25.63741 -29.21940 4.61030   1.000 41.96363 ? 430 THR B O   1 
ATOM   1103 C CB  . THR B 2 98  ? 25.50659 -31.56199 6.29880   1.000 48.46746 ? 430 THR B CB  1 
ATOM   1104 O OG1 . THR B 2 98  ? 25.51981 -32.92896 6.72686   1.000 45.98122 ? 430 THR B OG1 1 
ATOM   1105 C CG2 . THR B 2 98  ? 24.77739 -30.72209 7.33667   1.000 45.93596 ? 430 THR B CG2 1 
ATOM   1106 N N   . GLY B 2 99  ? 23.48796 -29.61925 4.06088   1.000 45.63098 ? 431 GLY B N   1 
ATOM   1107 C CA  . GLY B 2 99  ? 23.23416 -28.25612 3.63780   1.000 42.47706 ? 431 GLY B CA  1 
ATOM   1108 C C   . GLY B 2 99  ? 21.95631 -28.18992 2.81961   1.000 40.52391 ? 431 GLY B C   1 
ATOM   1109 O O   . GLY B 2 99  ? 21.13417 -29.10228 2.86081   1.000 44.08374 ? 431 GLY B O   1 
ATOM   1110 N N   . CYS B 2 100 ? 21.81902 -27.09386 2.07125   1.000 40.34921 ? 432 CYS B N   1 
ATOM   1111 C CA  . CYS B 2 100 ? 20.62039 -26.84464 1.28307   1.000 34.88318 ? 432 CYS B CA  1 
ATOM   1112 C C   . CYS B 2 100 ? 20.97823 -26.52252 -0.16100  1.000 38.00702 ? 432 CYS B C   1 
ATOM   1113 O O   . CYS B 2 100 ? 22.02049 -25.92526 -0.44646  1.000 35.88144 ? 432 CYS B O   1 
ATOM   1114 C CB  . CYS B 2 100 ? 19.79096 -25.69203 1.86623   1.000 35.21653 ? 432 CYS B CB  1 
ATOM   1115 S SG  . CYS B 2 100 ? 19.44819 -25.84595 3.64441   1.000 46.23560 ? 432 CYS B SG  1 
ATOM   1116 N N   . VAL B 2 101 ? 20.08662 -26.91790 -1.06564  1.000 35.82472 ? 433 VAL B N   1 
ATOM   1117 C CA  . VAL B 2 101 ? 20.16851 -26.57943 -2.48444  1.000 31.20186 ? 433 VAL B CA  1 
ATOM   1118 C C   . VAL B 2 101 ? 18.98613 -25.67338 -2.80744  1.000 37.51174 ? 433 VAL B C   1 
ATOM   1119 O O   . VAL B 2 101 ? 17.82728 -26.06411 -2.61558  1.000 37.64873 ? 433 VAL B O   1 
ATOM   1120 C CB  . VAL B 2 101 ? 20.16637 -27.83152 -3.37281  1.000 31.32073 ? 433 VAL B CB  1 
ATOM   1121 C CG1 . VAL B 2 101 ? 20.17761 -27.43606 -4.86427  1.000 26.59232 ? 433 VAL B CG1 1 
ATOM   1122 C CG2 . VAL B 2 101 ? 21.35562 -28.71690 -3.04982  1.000 32.61475 ? 433 VAL B CG2 1 
ATOM   1123 N N   . ILE B 2 102 ? 19.28144 -24.46251 -3.28116  1.000 33.07407 ? 434 ILE B N   1 
ATOM   1124 C CA  . ILE B 2 102 ? 18.28843 -23.43602 -3.58498  1.000 32.90124 ? 434 ILE B CA  1 
ATOM   1125 C C   . ILE B 2 102 ? 18.45794 -23.02821 -5.04681  1.000 41.57961 ? 434 ILE B C   1 
ATOM   1126 O O   . ILE B 2 102 ? 19.58540 -22.81180 -5.50610  1.000 42.01176 ? 434 ILE B O   1 
ATOM   1127 C CB  . ILE B 2 102 ? 18.44771 -22.22267 -2.64872  1.000 34.34193 ? 434 ILE B CB  1 
ATOM   1128 C CG1 . ILE B 2 102 ? 18.33591 -22.66718 -1.18395  1.000 39.60062 ? 434 ILE B CG1 1 
ATOM   1129 C CG2 . ILE B 2 102 ? 17.42578 -21.14330 -2.97692  1.000 41.99521 ? 434 ILE B CG2 1 
ATOM   1130 C CD1 . ILE B 2 102 ? 19.15240 -21.82416 -0.22579  1.000 39.83930 ? 434 ILE B CD1 1 
ATOM   1131 N N   . ALA B 2 103 ? 17.34626 -22.91598 -5.77636  1.000 37.65119 ? 435 ALA B N   1 
ATOM   1132 C CA  . ALA B 2 103 ? 17.41243 -22.57360 -7.19288  1.000 41.44223 ? 435 ALA B CA  1 
ATOM   1133 C C   . ALA B 2 103 ? 16.20692 -21.72866 -7.58232  1.000 44.14223 ? 435 ALA B C   1 
ATOM   1134 O O   . ALA B 2 103 ? 15.11934 -21.87487 -7.01469  1.000 42.30996 ? 435 ALA B O   1 
ATOM   1135 C CB  . ALA B 2 103 ? 17.47608 -23.82631 -8.07374  1.000 31.41109 ? 435 ALA B CB  1 
ATOM   1136 N N   . TRP B 2 104 ? 16.40813 -20.84071 -8.55839  1.000 39.06314 ? 436 TRP B N   1 
ATOM   1137 C CA  . TRP B 2 104 ? 15.30857 -20.03212 -9.06666  1.000 41.82134 ? 436 TRP B CA  1 
ATOM   1138 C C   . TRP B 2 104 ? 15.51707 -19.71397 -10.54230 1.000 43.54967 ? 436 TRP B C   1 
ATOM   1139 O O   . TRP B 2 104 ? 16.64620 -19.68433 -11.04238 1.000 38.56403 ? 436 TRP B O   1 
ATOM   1140 C CB  . TRP B 2 104 ? 15.13133 -18.73517 -8.26765  1.000 40.49065 ? 436 TRP B CB  1 
ATOM   1141 C CG  . TRP B 2 104 ? 16.30477 -17.79518 -8.27956  1.000 39.91596 ? 436 TRP B CG  1 
ATOM   1142 C CD1 . TRP B 2 104 ? 16.43123 -16.65401 -9.01218  1.000 46.35137 ? 436 TRP B CD1 1 
ATOM   1143 C CD2 . TRP B 2 104 ? 17.50023 -17.90045 -7.49425  1.000 42.96747 ? 436 TRP B CD2 1 
ATOM   1144 N NE1 . TRP B 2 104 ? 17.63540 -16.04517 -8.74238  1.000 44.20640 ? 436 TRP B NE1 1 
ATOM   1145 C CE2 . TRP B 2 104 ? 18.31081 -16.79256 -7.81507  1.000 43.17391 ? 436 TRP B CE2 1 
ATOM   1146 C CE3 . TRP B 2 104 ? 17.96453 -18.82573 -6.55347  1.000 44.16481 ? 436 TRP B CE3 1 
ATOM   1147 C CZ2 . TRP B 2 104 ? 19.55962 -16.58421 -7.22846  1.000 45.79742 ? 436 TRP B CZ2 1 
ATOM   1148 C CZ3 . TRP B 2 104 ? 19.20588 -18.61994 -5.97570  1.000 44.49532 ? 436 TRP B CZ3 1 
ATOM   1149 C CH2 . TRP B 2 104 ? 19.98887 -17.50795 -6.31530  1.000 39.67575 ? 436 TRP B CH2 1 
ATOM   1150 N N   . ASN B 2 105 ? 14.40365 -19.47452 -11.23011 1.000 40.30861 ? 437 ASN B N   1 
ATOM   1151 C CA  . ASN B 2 105 ? 14.43962 -19.12912 -12.64458 1.000 41.22179 ? 437 ASN B CA  1 
ATOM   1152 C C   . ASN B 2 105 ? 15.05450 -17.74712 -12.82997 1.000 43.94441 ? 437 ASN B C   1 
ATOM   1153 O O   . ASN B 2 105 ? 14.61850 -16.77432 -12.20740 1.000 46.71449 ? 437 ASN B O   1 
ATOM   1154 C CB  . ASN B 2 105 ? 13.02416 -19.16594 -13.21964 1.000 43.07150 ? 437 ASN B CB  1 
ATOM   1155 C CG  . ASN B 2 105 ? 12.98965 -18.90555 -14.70939 1.000 41.37403 ? 437 ASN B CG  1 
ATOM   1156 O OD1 . ASN B 2 105 ? 13.25374 -17.79150 -15.16455 1.000 44.90040 ? 437 ASN B OD1 1 
ATOM   1157 N ND2 . ASN B 2 105 ? 12.64457 -19.93097 -15.47916 1.000 41.44612 ? 437 ASN B ND2 1 
ATOM   1158 N N   . SER B 2 106 ? 16.06555 -17.65566 -13.68785 1.000 37.67504 ? 438 SER B N   1 
ATOM   1159 C CA  . SER B 2 106 ? 16.74976 -16.39631 -13.95580 1.000 38.42613 ? 438 SER B CA  1 
ATOM   1160 C C   . SER B 2 106 ? 16.65447 -16.01610 -15.42962 1.000 41.56623 ? 438 SER B C   1 
ATOM   1161 O O   . SER B 2 106 ? 17.56728 -15.40517 -15.98854 1.000 41.06765 ? 438 SER B O   1 
ATOM   1162 C CB  . SER B 2 106 ? 18.21016 -16.46432 -13.51557 1.000 44.98793 ? 438 SER B CB  1 
ATOM   1163 O OG  . SER B 2 106 ? 18.95566 -17.35981 -14.32557 1.000 40.41749 ? 438 SER B OG  1 
ATOM   1164 N N   . ASN B 2 107 ? 15.53279 -16.36178 -16.07006 1.000 42.74380 ? 439 ASN B N   1 
ATOM   1165 C CA  . ASN B 2 107 ? 15.35539 -16.05828 -17.49140 1.000 43.09716 ? 439 ASN B CA  1 
ATOM   1166 C C   . ASN B 2 107 ? 15.44750 -14.55887 -17.75605 1.000 46.54232 ? 439 ASN B C   1 
ATOM   1167 O O   . ASN B 2 107 ? 16.01297 -14.13462 -18.77014 1.000 47.64362 ? 439 ASN B O   1 
ATOM   1168 C CB  . ASN B 2 107 ? 14.01295 -16.60974 -17.97830 1.000 44.39245 ? 439 ASN B CB  1 
ATOM   1169 C CG  . ASN B 2 107 ? 13.90134 -16.65045 -19.50291 1.000 43.32303 ? 439 ASN B CG  1 
ATOM   1170 O OD1 . ASN B 2 107 ? 14.85413 -16.99142 -20.20383 1.000 45.78980 ? 439 ASN B OD1 1 
ATOM   1171 N ND2 . ASN B 2 107 ? 12.72775 -16.30477 -20.01515 1.000 42.24128 ? 439 ASN B ND2 1 
ATOM   1172 N N   . LYS B 2 108 ? 14.92100 -13.73656 -16.84286 1.000 48.78805 ? 440 LYS B N   1 
ATOM   1173 C CA  . LYS B 2 108 ? 14.92826 -12.29227 -17.05407 1.000 49.99280 ? 440 LYS B CA  1 
ATOM   1174 C C   . LYS B 2 108 ? 16.30530 -11.66500 -16.87923 1.000 51.79546 ? 440 LYS B C   1 
ATOM   1175 O O   . LYS B 2 108 ? 16.49123 -10.50999 -17.27726 1.000 56.76671 ? 440 LYS B O   1 
ATOM   1176 C CB  . LYS B 2 108 ? 13.93322 -11.60936 -16.11210 1.000 60.29108 ? 440 LYS B CB  1 
ATOM   1177 C CG  . LYS B 2 108 ? 12.52543 -11.49874 -16.67976 1.000 63.06170 ? 440 LYS B CG  1 
ATOM   1178 C CD  . LYS B 2 108 ? 11.65582 -10.56622 -15.84796 1.000 71.37395 ? 440 LYS B CD  1 
ATOM   1179 C CE  . LYS B 2 108 ? 10.32806 -10.28406 -16.54133 1.000 75.36206 ? 440 LYS B CE  1 
ATOM   1180 N NZ  . LYS B 2 108 ? 10.51741 -9.65515  -17.88150 1.000 78.86652 ? 440 LYS B NZ  1 
ATOM   1181 N N   . LEU B 2 109 ? 17.26969 -12.38486 -16.31235 1.000 51.94682 ? 441 LEU B N   1 
ATOM   1182 C CA  . LEU B 2 109 ? 18.60309 -11.84622 -16.06840 1.000 48.97962 ? 441 LEU B CA  1 
ATOM   1183 C C   . LEU B 2 109 ? 19.68002 -12.45999 -16.94814 1.000 48.43284 ? 441 LEU B C   1 
ATOM   1184 O O   . LEU B 2 109 ? 20.58530 -11.74802 -17.39050 1.000 50.07007 ? 441 LEU B O   1 
ATOM   1185 C CB  . LEU B 2 109 ? 18.99872 -12.04131 -14.59600 1.000 51.66415 ? 441 LEU B CB  1 
ATOM   1186 C CG  . LEU B 2 109 ? 18.15603 -11.41433 -13.47981 1.000 54.36560 ? 441 LEU B CG  1 
ATOM   1187 C CD1 . LEU B 2 109 ? 16.94053 -12.27386 -13.13754 1.000 56.13002 ? 441 LEU B CD1 1 
ATOM   1188 C CD2 . LEU B 2 109 ? 19.01158 -11.18236 -12.24042 1.000 54.56110 ? 441 LEU B CD2 1 
ATOM   1189 N N   . ASP B 2 110 ? 19.61491 -13.76590 -17.21540 1.000 45.85968 ? 442 ASP B N   1 
ATOM   1190 C CA  . ASP B 2 110 ? 20.70336 -14.46265 -17.88513 1.000 40.78365 ? 442 ASP B CA  1 
ATOM   1191 C C   . ASP B 2 110 ? 20.39459 -14.85652 -19.32521 1.000 46.99526 ? 442 ASP B C   1 
ATOM   1192 O O   . ASP B 2 110 ? 21.30989 -15.28961 -20.03301 1.000 42.37394 ? 442 ASP B O   1 
ATOM   1193 C CB  . ASP B 2 110 ? 21.10432 -15.71369 -17.08714 1.000 38.16210 ? 442 ASP B CB  1 
ATOM   1194 C CG  . ASP B 2 110 ? 21.66699 -15.37466 -15.70402 1.000 47.51609 ? 442 ASP B CG  1 
ATOM   1195 O OD1 . ASP B 2 110 ? 22.47131 -14.42385 -15.59405 1.000 42.73535 ? 442 ASP B OD1 1 
ATOM   1196 O OD2 . ASP B 2 110 ? 21.30476 -16.06099 -14.72530 1.000 43.71805 ? 442 ASP B OD2 1 
ATOM   1197 N N   . SER B 2 111 ? 19.14828 -14.72785 -19.77717 1.000 44.84674 ? 443 SER B N   1 
ATOM   1198 C CA  . SER B 2 111 ? 18.84253 -14.92748 -21.18709 1.000 41.19219 ? 443 SER B CA  1 
ATOM   1199 C C   . SER B 2 111 ? 19.13778 -13.65451 -21.97604 1.000 46.40247 ? 443 SER B C   1 
ATOM   1200 O O   . SER B 2 111 ? 19.33720 -12.57383 -21.41614 1.000 52.97437 ? 443 SER B O   1 
ATOM   1201 C CB  . SER B 2 111 ? 17.38417 -15.33854 -21.37642 1.000 42.66872 ? 443 SER B CB  1 
ATOM   1202 O OG  . SER B 2 111 ? 17.13825 -16.62225 -20.83112 1.000 47.52346 ? 443 SER B OG  1 
ATOM   1203 N N   . LYS B 2 112 ? 19.15115 -13.78816 -23.30035 1.000 45.92576 ? 444 LYS B N   1 
ATOM   1204 C CA  . LYS B 2 112 ? 19.50806 -12.67821 -24.17126 1.000 52.51651 ? 444 LYS B CA  1 
ATOM   1205 C C   . LYS B 2 112 ? 18.91284 -12.91227 -25.55117 1.000 50.01226 ? 444 LYS B C   1 
ATOM   1206 O O   . LYS B 2 112 ? 18.86691 -14.05002 -26.02613 1.000 49.16832 ? 444 LYS B O   1 
ATOM   1207 C CB  . LYS B 2 112 ? 21.03074 -12.52483 -24.28716 1.000 56.94878 ? 444 LYS B CB  1 
ATOM   1208 C CG  . LYS B 2 112 ? 21.65067 -11.44209 -23.41566 1.000 57.57667 ? 444 LYS B CG  1 
ATOM   1209 C CD  . LYS B 2 112 ? 23.08746 -11.16971 -23.85248 1.000 62.38524 ? 444 LYS B CD  1 
ATOM   1210 C CE  . LYS B 2 112 ? 23.16002 -10.91109 -25.35750 1.000 65.93918 ? 444 LYS B CE  1 
ATOM   1211 N NZ  . LYS B 2 112 ? 24.55260 -10.73256 -25.86450 1.000 68.47495 ? 444 LYS B NZ  1 
ATOM   1212 N N   . VAL B 2 113 ? 18.45735 -11.82950 -26.18584 1.000 56.37427 ? 445 VAL B N   1 
ATOM   1213 C CA  . VAL B 2 113 ? 18.09588 -11.90030 -27.59610 1.000 55.58028 ? 445 VAL B CA  1 
ATOM   1214 C C   . VAL B 2 113 ? 19.34609 -12.20764 -28.40415 1.000 58.34348 ? 445 VAL B C   1 
ATOM   1215 O O   . VAL B 2 113 ? 20.38216 -11.54633 -28.25505 1.000 59.65226 ? 445 VAL B O   1 
ATOM   1216 C CB  . VAL B 2 113 ? 17.43323 -10.59157 -28.05066 1.000 51.55207 ? 445 VAL B CB  1 
ATOM   1217 C CG1 . VAL B 2 113 ? 17.35440 -10.53504 -29.56426 1.000 60.01048 ? 445 VAL B CG1 1 
ATOM   1218 C CG2 . VAL B 2 113 ? 16.04579 -10.46614 -27.44213 1.000 61.31675 ? 445 VAL B CG2 1 
ATOM   1219 N N   . GLY B 2 114 ? 19.25903 -13.22367 -29.26089 1.000 56.90137 ? 446 GLY B N   1 
ATOM   1220 C CA  . GLY B 2 114 ? 20.41333 -13.71713 -29.97566 1.000 52.06786 ? 446 GLY B CA  1 
ATOM   1221 C C   . GLY B 2 114 ? 21.21309 -14.76280 -29.23117 1.000 55.82687 ? 446 GLY B C   1 
ATOM   1222 O O   . GLY B 2 114 ? 22.04424 -15.44120 -29.84872 1.000 53.45147 ? 446 GLY B O   1 
ATOM   1223 N N   . GLY B 2 115 ? 20.99190 -14.91474 -27.92806 1.000 50.14698 ? 447 GLY B N   1 
ATOM   1224 C CA  . GLY B 2 115 ? 21.64901 -15.95826 -27.17123 1.000 50.50817 ? 447 GLY B CA  1 
ATOM   1225 C C   . GLY B 2 115 ? 22.73298 -15.45047 -26.24696 1.000 48.17815 ? 447 GLY B C   1 
ATOM   1226 O O   . GLY B 2 115 ? 23.61074 -14.68563 -26.65808 1.000 52.97786 ? 447 GLY B O   1 
ATOM   1227 N N   . ASN B 2 116 ? 22.67675 -15.86667 -24.98635 1.000 50.73663 ? 448 ASN B N   1 
ATOM   1228 C CA  . ASN B 2 116 ? 23.71958 -15.55378 -24.01979 1.000 43.57196 ? 448 ASN B CA  1 
ATOM   1229 C C   . ASN B 2 116 ? 24.71734 -16.70334 -24.02943 1.000 44.28963 ? 448 ASN B C   1 
ATOM   1230 O O   . ASN B 2 116 ? 24.41631 -17.79848 -23.54500 1.000 50.35681 ? 448 ASN B O   1 
ATOM   1231 C CB  . ASN B 2 116 ? 23.12232 -15.34351 -22.62996 1.000 48.12885 ? 448 ASN B CB  1 
ATOM   1232 C CG  . ASN B 2 116 ? 24.16442 -14.97858 -21.59264 1.000 45.13515 ? 448 ASN B CG  1 
ATOM   1233 O OD1 . ASN B 2 116 ? 25.32635 -14.73305 -21.91907 1.000 48.69010 ? 448 ASN B OD1 1 
ATOM   1234 N ND2 . ASN B 2 116 ? 23.74866 -14.93124 -20.32924 1.000 46.22777 ? 448 ASN B ND2 1 
ATOM   1235 N N   . TYR B 2 117 ? 25.90603 -16.45923 -24.57665 1.000 41.67836 ? 449 TYR B N   1 
ATOM   1236 C CA  . TYR B 2 117 ? 26.93489 -17.48562 -24.65435 1.000 41.71221 ? 449 TYR B CA  1 
ATOM   1237 C C   . TYR B 2 117 ? 27.97150 -17.36989 -23.53843 1.000 42.84760 ? 449 TYR B C   1 
ATOM   1238 O O   . TYR B 2 117 ? 29.02188 -18.01908 -23.59952 1.000 39.58386 ? 449 TYR B O   1 
ATOM   1239 C CB  . TYR B 2 117 ? 27.58683 -17.45745 -26.03646 1.000 47.70174 ? 449 TYR B CB  1 
ATOM   1240 C CG  . TYR B 2 117 ? 26.64105 -18.01018 -27.07780 1.000 41.56103 ? 449 TYR B CG  1 
ATOM   1241 C CD1 . TYR B 2 117 ? 25.67710 -17.20200 -27.66794 1.000 44.41104 ? 449 TYR B CD1 1 
ATOM   1242 C CD2 . TYR B 2 117 ? 26.67046 -19.35516 -27.42493 1.000 46.08701 ? 449 TYR B CD2 1 
ATOM   1243 C CE1 . TYR B 2 117 ? 24.79004 -17.71208 -28.60167 1.000 44.73882 ? 449 TYR B CE1 1 
ATOM   1244 C CE2 . TYR B 2 117 ? 25.78915 -19.87374 -28.35815 1.000 46.88298 ? 449 TYR B CE2 1 
ATOM   1245 C CZ  . TYR B 2 117 ? 24.85091 -19.04834 -28.94182 1.000 49.84041 ? 449 TYR B CZ  1 
ATOM   1246 O OH  . TYR B 2 117 ? 23.97041 -19.56089 -29.87103 1.000 48.79175 ? 449 TYR B OH  1 
ATOM   1247 N N   . ASN B 2 118 ? 27.67594 -16.59266 -22.49914 1.000 45.72376 ? 450 ASN B N   1 
ATOM   1248 C CA  . ASN B 2 118 ? 28.60469 -16.43228 -21.38599 1.000 41.67445 ? 450 ASN B CA  1 
ATOM   1249 C C   . ASN B 2 118 ? 28.59672 -17.60921 -20.41746 1.000 41.52960 ? 450 ASN B C   1 
ATOM   1250 O O   . ASN B 2 118 ? 29.56425 -17.77964 -19.66596 1.000 42.46869 ? 450 ASN B O   1 
ATOM   1251 C CB  . ASN B 2 118 ? 28.28604 -15.14459 -20.63109 1.000 44.90967 ? 450 ASN B CB  1 
ATOM   1252 C CG  . ASN B 2 118 ? 28.70413 -13.91058 -21.39399 1.000 44.55097 ? 450 ASN B CG  1 
ATOM   1253 O OD1 . ASN B 2 118 ? 29.81381 -13.84296 -21.91971 1.000 53.49046 ? 450 ASN B OD1 1 
ATOM   1254 N ND2 . ASN B 2 118 ? 27.81344 -12.92821 -21.47046 1.000 49.77584 ? 450 ASN B ND2 1 
ATOM   1255 N N   . TYR B 2 119 ? 27.54343 -18.42057 -20.41220 1.000 36.38348 ? 451 TYR B N   1 
ATOM   1256 C CA  . TYR B 2 119 ? 27.43023 -19.55053 -19.49714 1.000 35.94370 ? 451 TYR B CA  1 
ATOM   1257 C C   . TYR B 2 119 ? 27.76934 -20.85001 -20.21691 1.000 39.29208 ? 451 TYR B C   1 
ATOM   1258 O O   . TYR B 2 119 ? 27.15970 -21.17776 -21.24363 1.000 40.74959 ? 451 TYR B O   1 
ATOM   1259 C CB  . TYR B 2 119 ? 26.02327 -19.62289 -18.90872 1.000 37.28260 ? 451 TYR B CB  1 
ATOM   1260 C CG  . TYR B 2 119 ? 25.72294 -18.52806 -17.90651 1.000 36.57843 ? 451 TYR B CG  1 
ATOM   1261 C CD1 . TYR B 2 119 ? 26.18802 -18.61361 -16.60075 1.000 37.91298 ? 451 TYR B CD1 1 
ATOM   1262 C CD2 . TYR B 2 119 ? 24.96629 -17.41673 -18.26287 1.000 37.30560 ? 451 TYR B CD2 1 
ATOM   1263 C CE1 . TYR B 2 119 ? 25.91535 -17.62095 -15.67981 1.000 36.56987 ? 451 TYR B CE1 1 
ATOM   1264 C CE2 . TYR B 2 119 ? 24.68555 -16.41834 -17.34580 1.000 43.40034 ? 451 TYR B CE2 1 
ATOM   1265 C CZ  . TYR B 2 119 ? 25.16013 -16.52857 -16.05347 1.000 38.57950 ? 451 TYR B CZ  1 
ATOM   1266 O OH  . TYR B 2 119 ? 24.88923 -15.54349 -15.12538 1.000 43.40226 ? 451 TYR B OH  1 
ATOM   1267 N N   . LEU B 2 120 ? 28.73223 -21.58979 -19.67142 1.000 39.18242 ? 452 LEU B N   1 
ATOM   1268 C CA  . LEU B 2 120 ? 29.25154 -22.80352 -20.28598 1.000 35.14862 ? 452 LEU B CA  1 
ATOM   1269 C C   . LEU B 2 120 ? 29.01290 -24.01132 -19.38510 1.000 39.11487 ? 452 LEU B C   1 
ATOM   1270 O O   . LEU B 2 120 ? 28.72904 -23.88058 -18.19169 1.000 36.23035 ? 452 LEU B O   1 
ATOM   1271 C CB  . LEU B 2 120 ? 30.75627 -22.67559 -20.57541 1.000 37.19402 ? 452 LEU B CB  1 
ATOM   1272 C CG  . LEU B 2 120 ? 31.28763 -21.99530 -21.84196 1.000 46.06586 ? 452 LEU B CG  1 
ATOM   1273 C CD1 . LEU B 2 120 ? 30.49184 -20.75797 -22.22794 1.000 45.60975 ? 452 LEU B CD1 1 
ATOM   1274 C CD2 . LEU B 2 120 ? 32.74930 -21.63399 -21.63024 1.000 46.86933 ? 452 LEU B CD2 1 
ATOM   1275 N N   . TYR B 2 121 ? 29.13970 -25.19927 -19.97587 1.000 31.83048 ? 453 TYR B N   1 
ATOM   1276 C CA  . TYR B 2 121 ? 29.09949 -26.45569 -19.23797 1.000 32.23898 ? 453 TYR B CA  1 
ATOM   1277 C C   . TYR B 2 121 ? 30.04270 -27.44041 -19.91249 1.000 34.69568 ? 453 TYR B C   1 
ATOM   1278 O O   . TYR B 2 121 ? 30.36673 -27.30504 -21.09647 1.000 35.35142 ? 453 TYR B O   1 
ATOM   1279 C CB  . TYR B 2 121 ? 27.67567 -27.03579 -19.15778 1.000 34.83243 ? 453 TYR B CB  1 
ATOM   1280 C CG  . TYR B 2 121 ? 27.05730 -27.38229 -20.50618 1.000 31.72973 ? 453 TYR B CG  1 
ATOM   1281 C CD1 . TYR B 2 121 ? 26.41029 -26.41657 -21.26579 1.000 35.95777 ? 453 TYR B CD1 1 
ATOM   1282 C CD2 . TYR B 2 121 ? 27.11005 -28.67951 -21.00460 1.000 33.42663 ? 453 TYR B CD2 1 
ATOM   1283 C CE1 . TYR B 2 121 ? 25.84315 -26.73062 -22.49955 1.000 36.36279 ? 453 TYR B CE1 1 
ATOM   1284 C CE2 . TYR B 2 121 ? 26.54659 -29.00117 -22.23191 1.000 36.41860 ? 453 TYR B CE2 1 
ATOM   1285 C CZ  . TYR B 2 121 ? 25.91747 -28.02387 -22.97174 1.000 36.06860 ? 453 TYR B CZ  1 
ATOM   1286 O OH  . TYR B 2 121 ? 25.35738 -28.34138 -24.18730 1.000 35.15569 ? 453 TYR B OH  1 
ATOM   1287 N N   . ARG B 2 122 ? 30.47349 -28.44553 -19.15364 1.000 32.10890 ? 454 ARG B N   1 
ATOM   1288 C CA  . ARG B 2 122 ? 31.38376 -29.45920 -19.67576 1.000 34.31328 ? 454 ARG B CA  1 
ATOM   1289 C C   . ARG B 2 122 ? 30.58408 -30.63610 -20.22426 1.000 34.77801 ? 454 ARG B C   1 
ATOM   1290 O O   . ARG B 2 122 ? 29.81972 -31.27280 -19.49274 1.000 32.89881 ? 454 ARG B O   1 
ATOM   1291 C CB  . ARG B 2 122 ? 32.36683 -29.93752 -18.60872 1.000 36.08777 ? 454 ARG B CB  1 
ATOM   1292 C CG  . ARG B 2 122 ? 33.39896 -30.91884 -19.15872 1.000 37.29648 ? 454 ARG B CG  1 
ATOM   1293 C CD  . ARG B 2 122 ? 34.42067 -31.35215 -18.11534 1.000 41.18058 ? 454 ARG B CD  1 
ATOM   1294 N NE  . ARG B 2 122 ? 35.13206 -30.21880 -17.53822 1.000 36.69352 ? 454 ARG B NE  1 
ATOM   1295 C CZ  . ARG B 2 122 ? 36.08162 -29.52853 -18.15601 1.000 43.12619 ? 454 ARG B CZ  1 
ATOM   1296 N NH1 . ARG B 2 122 ? 36.45305 -29.81452 -19.39617 1.000 41.30888 ? 454 ARG B NH1 1 
ATOM   1297 N NH2 . ARG B 2 122 ? 36.66648 -28.51866 -17.51713 1.000 38.66859 ? 454 ARG B NH2 1 
ATOM   1298 N N   . LEU B 2 123 ? 30.76633 -30.92231 -21.51360 1.000 31.04844 ? 455 LEU B N   1 
ATOM   1299 C CA  . LEU B 2 123 ? 30.07956 -32.02974 -22.16523 1.000 32.45344 ? 455 LEU B CA  1 
ATOM   1300 C C   . LEU B 2 123 ? 30.90927 -33.30948 -22.18980 1.000 35.94117 ? 455 LEU B C   1 
ATOM   1301 O O   . LEU B 2 123 ? 30.34363 -34.40659 -22.09742 1.000 36.38766 ? 455 LEU B O   1 
ATOM   1302 C CB  . LEU B 2 123 ? 29.69494 -31.62460 -23.59546 1.000 33.46566 ? 455 LEU B CB  1 
ATOM   1303 C CG  . LEU B 2 123 ? 28.93510 -32.64684 -24.44213 1.000 35.41902 ? 455 LEU B CG  1 
ATOM   1304 C CD1 . LEU B 2 123 ? 27.70970 -33.14973 -23.70024 1.000 35.91294 ? 455 LEU B CD1 1 
ATOM   1305 C CD2 . LEU B 2 123 ? 28.54762 -32.03704 -25.77918 1.000 37.97412 ? 455 LEU B CD2 1 
ATOM   1306 N N   . PHE B 2 124 ? 32.23332 -33.19651 -22.28903 1.000 34.71258 ? 456 PHE B N   1 
ATOM   1307 C CA  . PHE B 2 124 ? 33.12479 -34.34328 -22.41048 1.000 35.38907 ? 456 PHE B CA  1 
ATOM   1308 C C   . PHE B 2 124 ? 34.04106 -34.42339 -21.19766 1.000 34.94116 ? 456 PHE B C   1 
ATOM   1309 O O   . PHE B 2 124 ? 34.61283 -33.40985 -20.78534 1.000 35.20470 ? 456 PHE B O   1 
ATOM   1310 C CB  . PHE B 2 124 ? 33.98235 -34.24429 -23.67156 1.000 36.30457 ? 456 PHE B CB  1 
ATOM   1311 C CG  . PHE B 2 124 ? 33.19657 -34.17035 -24.95288 1.000 37.23544 ? 456 PHE B CG  1 
ATOM   1312 C CD1 . PHE B 2 124 ? 32.87812 -35.32456 -25.65173 1.000 39.23006 ? 456 PHE B CD1 1 
ATOM   1313 C CD2 . PHE B 2 124 ? 32.79862 -32.94879 -25.46958 1.000 37.05452 ? 456 PHE B CD2 1 
ATOM   1314 C CE1 . PHE B 2 124 ? 32.16599 -35.26195 -26.84289 1.000 37.42502 ? 456 PHE B CE1 1 
ATOM   1315 C CE2 . PHE B 2 124 ? 32.08540 -32.88328 -26.67106 1.000 39.45934 ? 456 PHE B CE2 1 
ATOM   1316 C CZ  . PHE B 2 124 ? 31.76710 -34.04164 -27.34894 1.000 36.65479 ? 456 PHE B CZ  1 
ATOM   1317 N N   . ARG B 2 125 ? 34.20761 -35.63094 -20.65858 1.000 35.01752 ? 457 ARG B N   1 
ATOM   1318 C CA  . ARG B 2 125 ? 35.15526 -35.88117 -19.58061 1.000 40.80856 ? 457 ARG B CA  1 
ATOM   1319 C C   . ARG B 2 125 ? 35.35333 -37.38497 -19.44768 1.000 42.48698 ? 457 ARG B C   1 
ATOM   1320 O O   . ARG B 2 125 ? 34.39172 -38.15039 -19.54818 1.000 42.78411 ? 457 ARG B O   1 
ATOM   1321 C CB  . ARG B 2 125 ? 34.67513 -35.28532 -18.25002 1.000 37.40499 ? 457 ARG B CB  1 
ATOM   1322 C CG  . ARG B 2 125 ? 35.80930 -35.01374 -17.27630 1.000 37.78126 ? 457 ARG B CG  1 
ATOM   1323 C CD  . ARG B 2 125 ? 35.31022 -34.46751 -15.94946 1.000 41.83130 ? 457 ARG B CD  1 
ATOM   1324 N NE  . ARG B 2 125 ? 36.41619 -33.95141 -15.15215 1.000 43.53055 ? 457 ARG B NE  1 
ATOM   1325 C CZ  . ARG B 2 125 ? 37.01302 -34.61582 -14.17223 1.000 44.23849 ? 457 ARG B CZ  1 
ATOM   1326 N NH1 . ARG B 2 125 ? 36.60706 -35.81971 -13.80559 1.000 43.00688 ? 457 ARG B NH1 1 
ATOM   1327 N NH2 . ARG B 2 125 ? 38.04059 -34.05514 -13.54178 1.000 45.61877 ? 457 ARG B NH2 1 
ATOM   1328 N N   . LYS B 2 126 ? 36.60111 -37.79977 -19.20529 1.000 43.62032 ? 458 LYS B N   1 
ATOM   1329 C CA  . LYS B 2 126 ? 36.90631 -39.22867 -19.18385 1.000 45.37836 ? 458 LYS B CA  1 
ATOM   1330 C C   . LYS B 2 126 ? 36.31871 -39.92559 -17.96233 1.000 48.01236 ? 458 LYS B C   1 
ATOM   1331 O O   . LYS B 2 126 ? 35.94868 -41.10192 -18.04704 1.000 49.88053 ? 458 LYS B O   1 
ATOM   1332 C CB  . LYS B 2 126 ? 38.42012 -39.45360 -19.25099 1.000 47.84809 ? 458 LYS B CB  1 
ATOM   1333 C CG  . LYS B 2 126 ? 39.02099 -39.33407 -20.65584 1.000 54.60526 ? 458 LYS B CG  1 
ATOM   1334 C CD  . LYS B 2 126 ? 38.39607 -40.33904 -21.62179 1.000 55.43079 ? 458 LYS B CD  1 
ATOM   1335 C CE  . LYS B 2 126 ? 39.21781 -40.51159 -22.90521 1.000 57.79078 ? 458 LYS B CE  1 
ATOM   1336 N NZ  . LYS B 2 126 ? 39.51966 -39.22783 -23.60241 1.000 50.27512 ? 458 LYS B NZ  1 
ATOM   1337 N N   . SER B 2 127 ? 36.22236 -39.23479 -16.82660 1.000 46.48140 ? 459 SER B N   1 
ATOM   1338 C CA  . SER B 2 127 ? 35.68056 -39.83195 -15.61515 1.000 45.42462 ? 459 SER B CA  1 
ATOM   1339 C C   . SER B 2 127 ? 34.81106 -38.81608 -14.88765 1.000 42.17687 ? 459 SER B C   1 
ATOM   1340 O O   . SER B 2 127 ? 34.87498 -37.61205 -15.14763 1.000 42.50453 ? 459 SER B O   1 
ATOM   1341 C CB  . SER B 2 127 ? 36.79380 -40.33550 -14.68434 1.000 48.15574 ? 459 SER B CB  1 
ATOM   1342 O OG  . SER B 2 127 ? 37.70976 -39.29913 -14.38129 1.000 41.27968 ? 459 SER B OG  1 
ATOM   1343 N N   . ASN B 2 128 ? 33.99450 -39.32019 -13.96517 1.000 40.29703 ? 460 ASN B N   1 
ATOM   1344 C CA  . ASN B 2 128 ? 33.12092 -38.45698 -13.18123 1.000 43.80595 ? 460 ASN B CA  1 
ATOM   1345 C C   . ASN B 2 128 ? 33.91142 -37.70603 -12.11650 1.000 43.61402 ? 460 ASN B C   1 
ATOM   1346 O O   . ASN B 2 128 ? 34.93073 -38.18373 -11.61193 1.000 43.84547 ? 460 ASN B O   1 
ATOM   1347 C CB  . ASN B 2 128 ? 32.01149 -39.26829 -12.50707 1.000 35.82785 ? 460 ASN B CB  1 
ATOM   1348 C CG  . ASN B 2 128 ? 31.13305 -40.00057 -13.49900 1.000 42.68712 ? 460 ASN B CG  1 
ATOM   1349 O OD1 . ASN B 2 128 ? 31.10129 -39.66784 -14.68410 1.000 45.38526 ? 460 ASN B OD1 1 
ATOM   1350 N ND2 . ASN B 2 128 ? 30.40650 -41.00050 -13.01637 1.000 46.53295 ? 460 ASN B ND2 1 
ATOM   1351 N N   . LEU B 2 129 ? 33.41950 -36.51903 -11.77252 1.000 41.08132 ? 461 LEU B N   1 
ATOM   1352 C CA  . LEU B 2 129 ? 34.03086 -35.72206 -10.72242 1.000 38.87000 ? 461 LEU B CA  1 
ATOM   1353 C C   . LEU B 2 129 ? 33.83788 -36.37917 -9.36295  1.000 41.62626 ? 461 LEU B C   1 
ATOM   1354 O O   . LEU B 2 129 ? 32.86166 -37.09527 -9.12419  1.000 44.26557 ? 461 LEU B O   1 
ATOM   1355 C CB  . LEU B 2 129 ? 33.42285 -34.32133 -10.68668 1.000 39.23503 ? 461 LEU B CB  1 
ATOM   1356 C CG  . LEU B 2 129 ? 33.70646 -33.33845 -11.81737 1.000 37.80392 ? 461 LEU B CG  1 
ATOM   1357 C CD1 . LEU B 2 129 ? 32.85058 -32.10679 -11.62680 1.000 37.47853 ? 461 LEU B CD1 1 
ATOM   1358 C CD2 . LEU B 2 129 ? 35.17265 -32.95879 -11.83250 1.000 39.88404 ? 461 LEU B CD2 1 
ATOM   1359 N N   . LYS B 2 130 ? 34.78760 -36.13124 -8.47042  1.000 42.56322 ? 462 LYS B N   1 
ATOM   1360 C CA  . LYS B 2 130 ? 34.58380 -36.40456 -7.05966  1.000 43.20275 ? 462 LYS B CA  1 
ATOM   1361 C C   . LYS B 2 130 ? 33.70586 -35.30913 -6.46588  1.000 39.62051 ? 462 LYS B C   1 
ATOM   1362 O O   . LYS B 2 130 ? 33.55239 -34.23929 -7.06094  1.000 41.43983 ? 462 LYS B O   1 
ATOM   1363 C CB  . LYS B 2 130 ? 35.92472 -36.46098 -6.33576  1.000 48.22500 ? 462 LYS B CB  1 
ATOM   1364 C CG  . LYS B 2 130 ? 36.96468 -37.34687 -7.00033  1.000 44.51342 ? 462 LYS B CG  1 
ATOM   1365 C CD  . LYS B 2 130 ? 38.33747 -37.10882 -6.38547  1.000 53.86329 ? 462 LYS B CD  1 
ATOM   1366 C CE  . LYS B 2 130 ? 38.69322 -35.62320 -6.39523  1.000 53.82820 ? 462 LYS B CE  1 
ATOM   1367 N NZ  . LYS B 2 130 ? 39.99600 -35.34373 -5.72291  1.000 49.63721 ? 462 LYS B NZ  1 
ATOM   1368 N N   . PRO B 2 131 ? 33.09973 -35.55025 -5.30592  1.000 45.80143 ? 463 PRO B N   1 
ATOM   1369 C CA  . PRO B 2 131 ? 32.30671 -34.49424 -4.66651  1.000 39.94648 ? 463 PRO B CA  1 
ATOM   1370 C C   . PRO B 2 131 ? 33.11408 -33.21829 -4.47545  1.000 41.37786 ? 463 PRO B C   1 
ATOM   1371 O O   . PRO B 2 131 ? 34.25808 -33.24451 -4.01318  1.000 36.96313 ? 463 PRO B O   1 
ATOM   1372 C CB  . PRO B 2 131 ? 31.90698 -35.12151 -3.32868  1.000 41.46796 ? 463 PRO B CB  1 
ATOM   1373 C CG  . PRO B 2 131 ? 31.84922 -36.57569 -3.62255  1.000 46.00548 ? 463 PRO B CG  1 
ATOM   1374 C CD  . PRO B 2 131 ? 32.95930 -36.83833 -4.60285  1.000 46.35354 ? 463 PRO B CD  1 
ATOM   1375 N N   . PHE B 2 132 ? 32.51495 -32.09534 -4.86996  1.000 33.72271 ? 464 PHE B N   1 
ATOM   1376 C CA  . PHE B 2 132 ? 33.09138 -30.76465 -4.70213  1.000 35.18468 ? 464 PHE B CA  1 
ATOM   1377 C C   . PHE B 2 132 ? 34.39547 -30.58647 -5.47258  1.000 42.47954 ? 464 PHE B C   1 
ATOM   1378 O O   . PHE B 2 132 ? 35.18341 -29.68666 -5.16431  1.000 39.22415 ? 464 PHE B O   1 
ATOM   1379 C CB  . PHE B 2 132 ? 33.29714 -30.43844 -3.21916  1.000 41.15357 ? 464 PHE B CB  1 
ATOM   1380 C CG  . PHE B 2 132 ? 32.01809 -30.31128 -2.45093  1.000 38.44181 ? 464 PHE B CG  1 
ATOM   1381 C CD1 . PHE B 2 132 ? 30.94643 -29.61409 -2.98186  1.000 40.95307 ? 464 PHE B CD1 1 
ATOM   1382 C CD2 . PHE B 2 132 ? 31.87936 -30.89742 -1.20347  1.000 45.54746 ? 464 PHE B CD2 1 
ATOM   1383 C CE1 . PHE B 2 132 ? 29.76313 -29.49172 -2.27819  1.000 43.52874 ? 464 PHE B CE1 1 
ATOM   1384 C CE2 . PHE B 2 132 ? 30.69650 -30.78094 -0.49421  1.000 41.11556 ? 464 PHE B CE2 1 
ATOM   1385 C CZ  . PHE B 2 132 ? 29.63752 -30.07650 -1.03258  1.000 41.26238 ? 464 PHE B CZ  1 
ATOM   1386 N N   . GLU B 2 133 ? 34.63839 -31.42204 -6.47712  1.000 41.64780 ? 465 GLU B N   1 
ATOM   1387 C CA  . GLU B 2 133 ? 35.75383 -31.20238 -7.38212  1.000 45.16503 ? 465 GLU B CA  1 
ATOM   1388 C C   . GLU B 2 133 ? 35.37543 -30.14947 -8.41567  1.000 38.01920 ? 465 GLU B C   1 
ATOM   1389 O O   . GLU B 2 133 ? 34.20496 -30.00250 -8.77978  1.000 39.11520 ? 465 GLU B O   1 
ATOM   1390 C CB  . GLU B 2 133 ? 36.15280 -32.50581 -8.07579  1.000 44.90853 ? 465 GLU B CB  1 
ATOM   1391 C CG  . GLU B 2 133 ? 37.38807 -32.39350 -8.95897  1.000 42.20801 ? 465 GLU B CG  1 
ATOM   1392 C CD  . GLU B 2 133 ? 37.86038 -33.73647 -9.47589  1.000 44.57082 ? 465 GLU B CD  1 
ATOM   1393 O OE1 . GLU B 2 133 ? 37.17711 -34.74855 -9.20946  1.000 43.51593 ? 465 GLU B OE1 1 
ATOM   1394 O OE2 . GLU B 2 133 ? 38.91517 -33.77706 -10.14783 1.000 52.09142 ? 465 GLU B OE2 1 
ATOM   1395 N N   . ARG B 2 134 ? 36.37522 -29.39055 -8.86422  1.000 36.30143 ? 466 ARG B N   1 
ATOM   1396 C CA  . ARG B 2 134 ? 36.19035 -28.37618 -9.89610  1.000 39.44145 ? 466 ARG B CA  1 
ATOM   1397 C C   . ARG B 2 134 ? 37.23273 -28.58963 -10.98406 1.000 39.56225 ? 466 ARG B C   1 
ATOM   1398 O O   . ARG B 2 134 ? 38.43683 -28.56057 -10.70953 1.000 38.69559 ? 466 ARG B O   1 
ATOM   1399 C CB  . ARG B 2 134 ? 36.30015 -26.96207 -9.31590  1.000 40.54771 ? 466 ARG B CB  1 
ATOM   1400 C CG  . ARG B 2 134 ? 35.88624 -25.88113 -10.29315 1.000 40.40207 ? 466 ARG B CG  1 
ATOM   1401 C CD  . ARG B 2 134 ? 36.41340 -24.50736 -9.91469  1.000 42.70931 ? 466 ARG B CD  1 
ATOM   1402 N NE  . ARG B 2 134 ? 35.57688 -23.83647 -8.92815  1.000 46.55623 ? 466 ARG B NE  1 
ATOM   1403 C CZ  . ARG B 2 134 ? 35.84555 -23.78874 -7.62963  1.000 50.69397 ? 466 ARG B CZ  1 
ATOM   1404 N NH1 . ARG B 2 134 ? 36.92941 -24.35767 -7.12900  1.000 56.03056 ? 466 ARG B NH1 1 
ATOM   1405 N NH2 . ARG B 2 134 ? 35.00661 -23.15209 -6.81324  1.000 45.68250 ? 466 ARG B NH2 1 
ATOM   1406 N N   . ASP B 2 135 ? 36.77286 -28.80046 -12.21454 1.000 40.78536 ? 467 ASP B N   1 
ATOM   1407 C CA  . ASP B 2 135 ? 37.64571 -29.01280 -13.36470 1.000 39.15087 ? 467 ASP B CA  1 
ATOM   1408 C C   . ASP B 2 135 ? 37.43047 -27.85105 -14.32334 1.000 39.75904 ? 467 ASP B C   1 
ATOM   1409 O O   . ASP B 2 135 ? 36.36416 -27.73942 -14.93657 1.000 35.13401 ? 467 ASP B O   1 
ATOM   1410 C CB  . ASP B 2 135 ? 37.34469 -30.35664 -14.02881 1.000 38.09629 ? 467 ASP B CB  1 
ATOM   1411 C CG  . ASP B 2 135 ? 38.21428 -30.62871 -15.25082 1.000 39.37929 ? 467 ASP B CG  1 
ATOM   1412 O OD1 . ASP B 2 135 ? 39.03449 -29.76757 -15.63398 1.000 40.05672 ? 467 ASP B OD1 1 
ATOM   1413 O OD2 . ASP B 2 135 ? 38.07449 -31.72457 -15.83144 1.000 38.73828 ? 467 ASP B OD2 1 
ATOM   1414 N N   . ILE B 2 136 ? 38.43457 -26.98285 -14.44882 1.000 40.02485 ? 468 ILE B N   1 
ATOM   1415 C CA  . ILE B 2 136 ? 38.35022 -25.82674 -15.33317 1.000 39.91889 ? 468 ILE B CA  1 
ATOM   1416 C C   . ILE B 2 136 ? 39.23279 -25.98507 -16.56647 1.000 38.47614 ? 468 ILE B C   1 
ATOM   1417 O O   . ILE B 2 136 ? 39.41157 -25.02229 -17.32110 1.000 34.49650 ? 468 ILE B O   1 
ATOM   1418 C CB  . ILE B 2 136 ? 38.68541 -24.52185 -14.59318 1.000 39.21590 ? 468 ILE B CB  1 
ATOM   1419 C CG1 . ILE B 2 136 ? 40.07830 -24.60094 -13.96506 1.000 45.47563 ? 468 ILE B CG1 1 
ATOM   1420 C CG2 . ILE B 2 136 ? 37.62268 -24.20931 -13.54272 1.000 39.42697 ? 468 ILE B CG2 1 
ATOM   1421 C CD1 . ILE B 2 136 ? 40.70280 -23.24692 -13.72405 1.000 47.37265 ? 468 ILE B CD1 1 
ATOM   1422 N N   . SER B 2 137 ? 39.78586 -27.17331 -16.79358 1.000 33.43165 ? 469 SER B N   1 
ATOM   1423 C CA  . SER B 2 137 ? 40.67335 -27.38038 -17.92865 1.000 39.05983 ? 469 SER B CA  1 
ATOM   1424 C C   . SER B 2 137 ? 39.89957 -27.33558 -19.24150 1.000 43.93042 ? 469 SER B C   1 
ATOM   1425 O O   . SER B 2 137 ? 38.69890 -27.61940 -19.29427 1.000 37.00586 ? 469 SER B O   1 
ATOM   1426 C CB  . SER B 2 137 ? 41.40429 -28.71591 -17.80030 1.000 41.27214 ? 469 SER B CB  1 
ATOM   1427 O OG  . SER B 2 137 ? 40.49641 -29.80309 -17.81978 1.000 42.59443 ? 469 SER B OG  1 
ATOM   1428 N N   . THR B 2 138 ? 40.60803 -26.96431 -20.31162 1.000 40.95424 ? 470 THR B N   1 
ATOM   1429 C CA  . THR B 2 138 ? 40.05047 -26.90529 -21.65753 1.000 42.25978 ? 470 THR B CA  1 
ATOM   1430 C C   . THR B 2 138 ? 40.84927 -27.76302 -22.63532 1.000 44.92185 ? 470 THR B C   1 
ATOM   1431 O O   . THR B 2 138 ? 40.98105 -27.41522 -23.81022 1.000 51.34911 ? 470 THR B O   1 
ATOM   1432 C CB  . THR B 2 138 ? 39.98036 -25.46222 -22.15979 1.000 50.27925 ? 470 THR B CB  1 
ATOM   1433 O OG1 . THR B 2 138 ? 41.25423 -24.82820 -21.98851 1.000 52.24877 ? 470 THR B OG1 1 
ATOM   1434 C CG2 . THR B 2 138 ? 38.91608 -24.67678 -21.40645 1.000 45.35814 ? 470 THR B CG2 1 
ATOM   1435 N N   . GLU B 2 139 ? 41.38176 -28.88825 -22.16752 1.000 42.76421 ? 471 GLU B N   1 
ATOM   1436 C CA  . GLU B 2 139 ? 42.09765 -29.79941 -23.04855 1.000 44.81865 ? 471 GLU B CA  1 
ATOM   1437 C C   . GLU B 2 139 ? 41.14385 -30.43693 -24.05504 1.000 46.50405 ? 471 GLU B C   1 
ATOM   1438 O O   . GLU B 2 139 ? 40.00068 -30.76744 -23.72743 1.000 44.73464 ? 471 GLU B O   1 
ATOM   1439 C CB  . GLU B 2 139 ? 42.79753 -30.88330 -22.23114 1.000 41.75059 ? 471 GLU B CB  1 
ATOM   1440 N N   . ILE B 2 140 ? 41.62198 -30.61114 -25.28944 1.000 42.18472 ? 472 ILE B N   1 
ATOM   1441 C CA  . ILE B 2 140 ? 40.82518 -31.27519 -26.31586 1.000 39.28439 ? 472 ILE B CA  1 
ATOM   1442 C C   . ILE B 2 140 ? 40.57671 -32.71986 -25.90651 1.000 40.39409 ? 472 ILE B C   1 
ATOM   1443 O O   . ILE B 2 140 ? 41.51171 -33.45624 -25.56639 1.000 47.82725 ? 472 ILE B O   1 
ATOM   1444 C CB  . ILE B 2 140 ? 41.52640 -31.19802 -27.67961 1.000 41.52238 ? 472 ILE B CB  1 
ATOM   1445 C CG1 . ILE B 2 140 ? 41.75328 -29.74089 -28.07776 1.000 40.48772 ? 472 ILE B CG1 1 
ATOM   1446 C CG2 . ILE B 2 140 ? 40.71023 -31.92405 -28.73944 1.000 41.86968 ? 472 ILE B CG2 1 
ATOM   1447 C CD1 . ILE B 2 140 ? 40.48483 -28.92203 -28.13794 1.000 48.65976 ? 472 ILE B CD1 1 
ATOM   1448 N N   . TYR B 2 141 ? 39.31133 -33.13112 -25.92713 1.000 41.83949 ? 473 TYR B N   1 
ATOM   1449 C CA  . TYR B 2 141 ? 38.94775 -34.48040 -25.51530 1.000 40.24982 ? 473 TYR B CA  1 
ATOM   1450 C C   . TYR B 2 141 ? 39.25047 -35.46815 -26.63516 1.000 48.15508 ? 473 TYR B C   1 
ATOM   1451 O O   . TYR B 2 141 ? 38.83277 -35.26946 -27.78119 1.000 41.98355 ? 473 TYR B O   1 
ATOM   1452 C CB  . TYR B 2 141 ? 37.46842 -34.53715 -25.13694 1.000 34.77423 ? 473 TYR B CB  1 
ATOM   1453 C CG  . TYR B 2 141 ? 36.99527 -35.89127 -24.65909 1.000 42.13513 ? 473 TYR B CG  1 
ATOM   1454 C CD1 . TYR B 2 141 ? 36.48788 -36.82515 -25.55069 1.000 44.44624 ? 473 TYR B CD1 1 
ATOM   1455 C CD2 . TYR B 2 141 ? 37.04268 -36.23062 -23.31068 1.000 40.53637 ? 473 TYR B CD2 1 
ATOM   1456 C CE1 . TYR B 2 141 ? 36.04940 -38.06232 -25.11840 1.000 48.22636 ? 473 TYR B CE1 1 
ATOM   1457 C CE2 . TYR B 2 141 ? 36.60391 -37.46573 -22.86963 1.000 43.84836 ? 473 TYR B CE2 1 
ATOM   1458 C CZ  . TYR B 2 141 ? 36.10820 -38.37660 -23.77798 1.000 48.83007 ? 473 TYR B CZ  1 
ATOM   1459 O OH  . TYR B 2 141 ? 35.67033 -39.60916 -23.35023 1.000 52.82755 ? 473 TYR B OH  1 
ATOM   1460 N N   . GLN B 2 142 ? 39.96430 -36.54016 -26.29856 1.000 48.87046 ? 474 GLN B N   1 
ATOM   1461 C CA  . GLN B 2 142 ? 40.37738 -37.55266 -27.26980 1.000 51.40745 ? 474 GLN B CA  1 
ATOM   1462 C C   . GLN B 2 142 ? 39.38252 -38.70801 -27.22170 1.000 48.02216 ? 474 GLN B C   1 
ATOM   1463 O O   . GLN B 2 142 ? 39.40966 -39.52799 -26.30067 1.000 45.20363 ? 474 GLN B O   1 
ATOM   1464 C CB  . GLN B 2 142 ? 41.79803 -38.02851 -26.98175 1.000 53.02683 ? 474 GLN B CB  1 
ATOM   1465 C CG  . GLN B 2 142 ? 42.26991 -39.15150 -27.89389 1.000 50.23650 ? 474 GLN B CG  1 
ATOM   1466 C CD  . GLN B 2 142 ? 43.65634 -39.65140 -27.53799 1.000 50.70350 ? 474 GLN B CD  1 
ATOM   1467 O OE1 . GLN B 2 142 ? 44.49993 -38.89391 -27.05412 1.000 50.39144 ? 474 GLN B OE1 1 
ATOM   1468 N NE2 . GLN B 2 142 ? 43.89627 -40.93553 -27.76909 1.000 49.69114 ? 474 GLN B NE2 1 
ATOM   1469 N N   . ALA B 2 143 ? 38.50985 -38.77785 -28.22741 1.000 46.34820 ? 475 ALA B N   1 
ATOM   1470 C CA  . ALA B 2 143 ? 37.50001 -39.82598 -28.29756 1.000 43.14325 ? 475 ALA B CA  1 
ATOM   1471 C C   . ALA B 2 143 ? 37.97680 -41.07505 -29.02785 1.000 54.96137 ? 475 ALA B C   1 
ATOM   1472 O O   . ALA B 2 143 ? 37.36915 -42.13986 -28.86556 1.000 55.87074 ? 475 ALA B O   1 
ATOM   1473 C CB  . ALA B 2 143 ? 36.23513 -39.29408 -28.98103 1.000 46.95435 ? 475 ALA B CB  1 
ATOM   1474 N N   . GLY B 2 144 ? 39.03816 -40.97371 -29.83037 1.000 56.12409 ? 476 GLY B N   1 
ATOM   1475 C CA  . GLY B 2 144 ? 39.58204 -42.09569 -30.54955 1.000 57.95866 ? 476 GLY B CA  1 
ATOM   1476 C C   . GLY B 2 144 ? 40.93132 -42.53320 -30.00889 1.000 57.37574 ? 476 GLY B C   1 
ATOM   1477 O O   . GLY B 2 144 ? 41.33511 -42.18177 -28.89733 1.000 55.19272 ? 476 GLY B O   1 
ATOM   1478 N N   . ASN B 2 145 ? 41.63577 -43.32219 -30.82155 1.000 57.70043 ? 477 ASN B N   1 
ATOM   1479 C CA  . ASN B 2 145 ? 42.96995 -43.78376 -30.45522 1.000 55.70871 ? 477 ASN B CA  1 
ATOM   1480 C C   . ASN B 2 145 ? 44.05796 -42.78360 -30.81300 1.000 53.14670 ? 477 ASN B C   1 
ATOM   1481 O O   . ASN B 2 145 ? 45.11813 -42.78006 -30.17718 1.000 55.16042 ? 477 ASN B O   1 
ATOM   1482 C CB  . ASN B 2 145 ? 43.27269 -45.12255 -31.13282 1.000 59.83818 ? 477 ASN B CB  1 
ATOM   1483 C CG  . ASN B 2 145 ? 42.39844 -46.24509 -30.61926 1.000 61.35183 ? 477 ASN B CG  1 
ATOM   1484 O OD1 . ASN B 2 145 ? 42.03312 -46.27396 -29.44451 1.000 63.76819 ? 477 ASN B OD1 1 
ATOM   1485 N ND2 . ASN B 2 145 ? 42.05828 -47.18021 -31.49940 1.000 56.32442 ? 477 ASN B ND2 1 
ATOM   1486 N N   . LYS B 2 146 ? 43.82643 -41.94169 -31.80510 1.000 55.11415 ? 478 LYS B N   1 
ATOM   1487 C CA  . LYS B 2 146 ? 44.84624 -40.98648 -32.21388 1.000 54.15365 ? 478 LYS B CA  1 
ATOM   1488 C C   . LYS B 2 146 ? 44.91559 -39.83646 -31.21815 1.000 54.44438 ? 478 LYS B C   1 
ATOM   1489 O O   . LYS B 2 146 ? 43.88169 -39.22976 -30.90577 1.000 49.96315 ? 478 LYS B O   1 
ATOM   1490 C CB  . LYS B 2 146 ? 44.55673 -40.45448 -33.61435 1.000 55.16453 ? 478 LYS B CB  1 
ATOM   1491 C CG  . LYS B 2 146 ? 44.47879 -41.53748 -34.68376 1.000 65.62603 ? 478 LYS B CG  1 
ATOM   1492 C CD  . LYS B 2 146 ? 44.25525 -40.93615 -36.06374 1.000 62.60336 ? 478 LYS B CD  1 
ATOM   1493 C CE  . LYS B 2 146 ? 44.19769 -42.01126 -37.14134 1.000 77.07290 ? 478 LYS B CE  1 
ATOM   1494 N NZ  . LYS B 2 146 ? 43.02537 -42.91798 -36.98302 1.000 82.34344 ? 478 LYS B NZ  1 
ATOM   1495 N N   . PRO B 2 147 ? 46.09287 -39.52562 -30.67684 1.000 50.30957 ? 479 PRO B N   1 
ATOM   1496 C CA  . PRO B 2 147 ? 46.23908 -38.31124 -29.87081 1.000 49.45321 ? 479 PRO B CA  1 
ATOM   1497 C C   . PRO B 2 147 ? 45.85402 -37.07892 -30.67494 1.000 49.62959 ? 479 PRO B C   1 
ATOM   1498 O O   . PRO B 2 147 ? 46.03646 -37.02261 -31.89236 1.000 45.29325 ? 479 PRO B O   1 
ATOM   1499 C CB  . PRO B 2 147 ? 47.72656 -38.30092 -29.50346 1.000 47.33484 ? 479 PRO B CB  1 
ATOM   1500 C CG  . PRO B 2 147 ? 48.12208 -39.74527 -29.54464 1.000 48.55012 ? 479 PRO B CG  1 
ATOM   1501 C CD  . PRO B 2 147 ? 47.31181 -40.35725 -30.65681 1.000 50.25333 ? 479 PRO B CD  1 
ATOM   1502 N N   . CYS B 2 148 ? 45.31789 -36.08239 -29.97624 1.000 43.62061 ? 480 CYS B N   1 
ATOM   1503 C CA  . CYS B 2 148 ? 44.74332 -34.91984 -30.63741 1.000 43.75866 ? 480 CYS B CA  1 
ATOM   1504 C C   . CYS B 2 148 ? 45.73260 -33.78196 -30.83523 1.000 50.37830 ? 480 CYS B C   1 
ATOM   1505 O O   . CYS B 2 148 ? 45.51064 -32.93828 -31.71244 1.000 46.75053 ? 480 CYS B O   1 
ATOM   1506 C CB  . CYS B 2 148 ? 43.53273 -34.41988 -29.84299 1.000 52.87339 ? 480 CYS B CB  1 
ATOM   1507 S SG  . CYS B 2 148 ? 42.14204 -35.57227 -29.89711 1.000 58.48379 ? 480 CYS B SG  1 
ATOM   1508 N N   . ASN B 2 149 ? 46.80604 -33.73431 -30.04294 1.000 48.97537 ? 481 ASN B N   1 
ATOM   1509 C CA  . ASN B 2 149 ? 47.84911 -32.71558 -30.17569 1.000 45.45490 ? 481 ASN B CA  1 
ATOM   1510 C C   . ASN B 2 149 ? 47.28224 -31.30165 -30.10147 1.000 51.60352 ? 481 ASN B C   1 
ATOM   1511 O O   . ASN B 2 149 ? 47.78952 -30.38513 -30.75310 1.000 48.13588 ? 481 ASN B O   1 
ATOM   1512 C CB  . ASN B 2 149 ? 48.64462 -32.90117 -31.47015 1.000 53.29643 ? 481 ASN B CB  1 
ATOM   1513 C CG  . ASN B 2 149 ? 49.33591 -34.24371 -31.53544 1.000 52.77551 ? 481 ASN B CG  1 
ATOM   1514 O OD1 . ASN B 2 149 ? 49.06035 -35.05661 -32.41877 1.000 55.54883 ? 481 ASN B OD1 1 
ATOM   1515 N ND2 . ASN B 2 149 ? 50.23795 -34.48759 -30.59569 1.000 51.28629 ? 481 ASN B ND2 1 
ATOM   1516 N N   . GLY B 2 150 ? 46.22379 -31.11721 -29.31367 1.000 52.26312 ? 482 GLY B N   1 
ATOM   1517 C CA  . GLY B 2 150 ? 45.64615 -29.80017 -29.13277 1.000 48.47135 ? 482 GLY B CA  1 
ATOM   1518 C C   . GLY B 2 150 ? 44.88719 -29.25494 -30.31993 1.000 51.70779 ? 482 GLY B C   1 
ATOM   1519 O O   . GLY B 2 150 ? 44.62517 -28.05015 -30.37201 1.000 53.95707 ? 482 GLY B O   1 
ATOM   1520 N N   . VAL B 2 151 ? 44.52141 -30.10090 -31.28042 1.000 52.51720 ? 483 VAL B N   1 
ATOM   1521 C CA  . VAL B 2 151 ? 43.78706 -29.67752 -32.46718 1.000 47.43513 ? 483 VAL B CA  1 
ATOM   1522 C C   . VAL B 2 151 ? 42.39933 -30.30352 -32.43094 1.000 44.40787 ? 483 VAL B C   1 
ATOM   1523 O O   . VAL B 2 151 ? 42.26403 -31.52405 -32.27221 1.000 41.93450 ? 483 VAL B O   1 
ATOM   1524 C CB  . VAL B 2 151 ? 44.52779 -30.06222 -33.75978 1.000 45.66085 ? 483 VAL B CB  1 
ATOM   1525 C CG1 . VAL B 2 151 ? 43.85469 -29.41390 -34.96207 1.000 50.60544 ? 483 VAL B CG1 1 
ATOM   1526 C CG2 . VAL B 2 151 ? 45.99283 -29.66124 -33.67599 1.000 53.19897 ? 483 VAL B CG2 1 
ATOM   1527 N N   . ALA B 2 152 ? 41.37314 -29.46844 -32.58344 1.000 45.40377 ? 484 ALA B N   1 
ATOM   1528 C CA  . ALA B 2 152 ? 40.00114 -29.94844 -32.64653 1.000 46.39455 ? 484 ALA B CA  1 
ATOM   1529 C C   . ALA B 2 152 ? 39.68373 -30.46195 -34.04576 1.000 40.60712 ? 484 ALA B C   1 
ATOM   1530 O O   . ALA B 2 152 ? 40.07800 -29.86099 -35.04969 1.000 42.22670 ? 484 ALA B O   1 
ATOM   1531 C CB  . ALA B 2 152 ? 39.02498 -28.83428 -32.26784 1.000 41.58812 ? 484 ALA B CB  1 
ATOM   1532 N N   . GLY B 2 153 ? 38.96248 -31.57809 -34.10162 1.000 39.77960 ? 485 GLY B N   1 
ATOM   1533 C CA  . GLY B 2 153 ? 38.55131 -32.17687 -35.35536 1.000 48.46105 ? 485 GLY B CA  1 
ATOM   1534 C C   . GLY B 2 153 ? 37.85858 -33.50730 -35.13515 1.000 49.61270 ? 485 GLY B C   1 
ATOM   1535 O O   . GLY B 2 153 ? 37.25453 -33.72464 -34.07792 1.000 46.56806 ? 485 GLY B O   1 
ATOM   1536 N N   . PHE B 2 154 ? 37.93687 -34.40688 -36.11654 1.000 45.10962 ? 486 PHE B N   1 
ATOM   1537 C CA  . PHE B 2 154 ? 37.36445 -35.73767 -35.95163 1.000 46.74992 ? 486 PHE B CA  1 
ATOM   1538 C C   . PHE B 2 154 ? 37.98618 -36.43340 -34.74637 1.000 45.35610 ? 486 PHE B C   1 
ATOM   1539 O O   . PHE B 2 154 ? 39.20954 -36.44059 -34.57913 1.000 45.51569 ? 486 PHE B O   1 
ATOM   1540 C CB  . PHE B 2 154 ? 37.57556 -36.56391 -37.22288 1.000 46.73262 ? 486 PHE B CB  1 
ATOM   1541 C CG  . PHE B 2 154 ? 36.95351 -37.93328 -37.16804 1.000 45.24981 ? 486 PHE B CG  1 
ATOM   1542 C CD1 . PHE B 2 154 ? 35.60372 -38.10570 -37.42496 1.000 50.16308 ? 486 PHE B CD1 1 
ATOM   1543 C CD2 . PHE B 2 154 ? 37.71769 -39.04727 -36.86054 1.000 40.72723 ? 486 PHE B CD2 1 
ATOM   1544 C CE1 . PHE B 2 154 ? 35.02490 -39.36393 -37.37199 1.000 47.08544 ? 486 PHE B CE1 1 
ATOM   1545 C CE2 . PHE B 2 154 ? 37.14786 -40.30639 -36.80750 1.000 47.57086 ? 486 PHE B CE2 1 
ATOM   1546 C CZ  . PHE B 2 154 ? 35.79725 -40.46444 -37.06173 1.000 48.81734 ? 486 PHE B CZ  1 
ATOM   1547 N N   . ASN B 2 155 ? 37.12998 -36.99489 -33.89259 1.000 44.94069 ? 487 ASN B N   1 
ATOM   1548 C CA  . ASN B 2 155 ? 37.49561 -37.65984 -32.64145 1.000 50.11578 ? 487 ASN B CA  1 
ATOM   1549 C C   . ASN B 2 155 ? 38.21101 -36.74129 -31.65373 1.000 42.43313 ? 487 ASN B C   1 
ATOM   1550 O O   . ASN B 2 155 ? 38.78008 -37.22946 -30.66670 1.000 47.19381 ? 487 ASN B O   1 
ATOM   1551 C CB  . ASN B 2 155 ? 38.35756 -38.90878 -32.88853 1.000 47.45627 ? 487 ASN B CB  1 
ATOM   1552 C CG  . ASN B 2 155 ? 37.53191 -40.16533 -33.07009 1.000 53.39241 ? 487 ASN B CG  1 
ATOM   1553 O OD1 . ASN B 2 155 ? 36.43382 -40.28643 -32.52885 1.000 52.43507 ? 487 ASN B OD1 1 
ATOM   1554 N ND2 . ASN B 2 155 ? 38.06378 -41.11533 -33.83249 1.000 55.98789 ? 487 ASN B ND2 1 
ATOM   1555 N N   . CYS B 2 156 ? 38.19549 -35.42599 -31.87987 1.000 41.51636 ? 488 CYS B N   1 
ATOM   1556 C CA  . CYS B 2 156 ? 38.94154 -34.47873 -31.04614 1.000 45.43254 ? 488 CYS B CA  1 
ATOM   1557 C C   . CYS B 2 156 ? 38.05639 -33.26197 -30.78958 1.000 40.52387 ? 488 CYS B C   1 
ATOM   1558 O O   . CYS B 2 156 ? 37.99385 -32.34808 -31.61536 1.000 40.33650 ? 488 CYS B O   1 
ATOM   1559 C CB  . CYS B 2 156 ? 40.25471 -34.08417 -31.71455 1.000 47.40860 ? 488 CYS B CB  1 
ATOM   1560 S SG  . CYS B 2 156 ? 41.46362 -35.43144 -31.81745 1.000 43.67104 ? 488 CYS B SG  1 
ATOM   1561 N N   . TYR B 2 157 ? 37.39390 -33.23770 -29.63508 1.000 40.41876 ? 489 TYR B N   1 
ATOM   1562 C CA  . TYR B 2 157 ? 36.33107 -32.27678 -29.37368 1.000 40.82712 ? 489 TYR B CA  1 
ATOM   1563 C C   . TYR B 2 157 ? 36.70920 -31.35036 -28.22683 1.000 42.93136 ? 489 TYR B C   1 
ATOM   1564 O O   . TYR B 2 157 ? 37.14666 -31.80887 -27.16463 1.000 40.19770 ? 489 TYR B O   1 
ATOM   1565 C CB  . TYR B 2 157 ? 35.01684 -33.00595 -29.07266 1.000 41.44889 ? 489 TYR B CB  1 
ATOM   1566 C CG  . TYR B 2 157 ? 34.69465 -34.05527 -30.11047 1.000 40.70099 ? 489 TYR B CG  1 
ATOM   1567 C CD1 . TYR B 2 157 ? 34.38030 -33.69039 -31.41529 1.000 42.84515 ? 489 TYR B CD1 1 
ATOM   1568 C CD2 . TYR B 2 157 ? 34.72691 -35.40905 -29.79676 1.000 39.14913 ? 489 TYR B CD2 1 
ATOM   1569 C CE1 . TYR B 2 157 ? 34.09805 -34.64477 -32.38146 1.000 44.09767 ? 489 TYR B CE1 1 
ATOM   1570 C CE2 . TYR B 2 157 ? 34.44327 -36.37330 -30.75619 1.000 43.40242 ? 489 TYR B CE2 1 
ATOM   1571 C CZ  . TYR B 2 157 ? 34.12919 -35.98365 -32.04585 1.000 44.70378 ? 489 TYR B CZ  1 
ATOM   1572 O OH  . TYR B 2 157 ? 33.84936 -36.93504 -33.00383 1.000 48.38639 ? 489 TYR B OH  1 
ATOM   1573 N N   . PHE B 2 158 ? 36.55721 -30.05034 -28.45816 1.000 44.76476 ? 490 PHE B N   1 
ATOM   1574 C CA  . PHE B 2 158 ? 36.64244 -29.07953 -27.37851 1.000 41.25150 ? 490 PHE B CA  1 
ATOM   1575 C C   . PHE B 2 158 ? 35.62442 -29.45901 -26.30698 1.000 41.98483 ? 490 PHE B C   1 
ATOM   1576 O O   . PHE B 2 158 ? 34.46896 -29.75588 -26.64099 1.000 41.91182 ? 490 PHE B O   1 
ATOM   1577 C CB  . PHE B 2 158 ? 36.37073 -27.67446 -27.91865 1.000 41.13738 ? 490 PHE B CB  1 
ATOM   1578 C CG  . PHE B 2 158 ? 36.61242 -26.57595 -26.92161 1.000 49.71369 ? 490 PHE B CG  1 
ATOM   1579 C CD1 . PHE B 2 158 ? 37.89624 -26.11320 -26.67974 1.000 51.50962 ? 490 PHE B CD1 1 
ATOM   1580 C CD2 . PHE B 2 158 ? 35.55280 -25.99451 -26.23774 1.000 43.85794 ? 490 PHE B CD2 1 
ATOM   1581 C CE1 . PHE B 2 158 ? 38.12348 -25.09696 -25.76313 1.000 50.86162 ? 490 PHE B CE1 1 
ATOM   1582 C CE2 . PHE B 2 158 ? 35.77043 -24.97640 -25.32419 1.000 44.91206 ? 490 PHE B CE2 1 
ATOM   1583 C CZ  . PHE B 2 158 ? 37.05885 -24.52709 -25.08571 1.000 48.18502 ? 490 PHE B CZ  1 
ATOM   1584 N N   . PRO B 2 159 ? 36.00651 -29.47835 -25.02241 1.000 42.59197 ? 491 PRO B N   1 
ATOM   1585 C CA  . PRO B 2 159 ? 35.16492 -30.15093 -24.01957 1.000 37.73575 ? 491 PRO B CA  1 
ATOM   1586 C C   . PRO B 2 159 ? 34.00010 -29.32505 -23.50269 1.000 35.32825 ? 491 PRO B C   1 
ATOM   1587 O O   . PRO B 2 159 ? 33.07911 -29.90301 -22.91099 1.000 35.23425 ? 491 PRO B O   1 
ATOM   1588 C CB  . PRO B 2 159 ? 36.15586 -30.45704 -22.88842 1.000 39.66979 ? 491 PRO B CB  1 
ATOM   1589 C CG  . PRO B 2 159 ? 37.12210 -29.31809 -22.95706 1.000 40.07189 ? 491 PRO B CG  1 
ATOM   1590 C CD  . PRO B 2 159 ? 37.26406 -28.98029 -24.43680 1.000 39.92743 ? 491 PRO B CD  1 
ATOM   1591 N N   . LEU B 2 160 ? 34.00260 -28.01194 -23.68990 1.000 37.64970 ? 492 LEU B N   1 
ATOM   1592 C CA  . LEU B 2 160 ? 32.94038 -27.16070 -23.17688 1.000 38.83508 ? 492 LEU B CA  1 
ATOM   1593 C C   . LEU B 2 160 ? 31.96107 -26.78799 -24.28307 1.000 43.94868 ? 492 LEU B C   1 
ATOM   1594 O O   . LEU B 2 160 ? 32.32487 -26.69195 -25.45834 1.000 41.02076 ? 492 LEU B O   1 
ATOM   1595 C CB  . LEU B 2 160 ? 33.51497 -25.88520 -22.55898 1.000 41.34041 ? 492 LEU B CB  1 
ATOM   1596 C CG  . LEU B 2 160 ? 34.65674 -26.05989 -21.55867 1.000 38.82695 ? 492 LEU B CG  1 
ATOM   1597 C CD1 . LEU B 2 160 ? 35.14842 -24.70116 -21.08312 1.000 38.49744 ? 492 LEU B CD1 1 
ATOM   1598 C CD2 . LEU B 2 160 ? 34.22110 -26.92002 -20.38116 1.000 38.70577 ? 492 LEU B CD2 1 
ATOM   1599 N N   . ARG B 2 161 ? 30.70646 -26.58708 -23.88958 1.000 36.17329 ? 493 ARG B N   1 
ATOM   1600 C CA  . ARG B 2 161 ? 29.69068 -26.00450 -24.74985 1.000 40.06731 ? 493 ARG B CA  1 
ATOM   1601 C C   . ARG B 2 161 ? 29.00518 -24.87709 -23.99606 1.000 42.00403 ? 493 ARG B C   1 
ATOM   1602 O O   . ARG B 2 161 ? 28.91190 -24.89483 -22.76250 1.000 38.36160 ? 493 ARG B O   1 
ATOM   1603 C CB  . ARG B 2 161 ? 28.64192 -27.03884 -25.19636 1.000 40.75637 ? 493 ARG B CB  1 
ATOM   1604 C CG  . ARG B 2 161 ? 29.18659 -28.15954 -26.05725 1.000 41.41662 ? 493 ARG B CG  1 
ATOM   1605 C CD  . ARG B 2 161 ? 29.60854 -27.64103 -27.42696 1.000 40.30905 ? 493 ARG B CD  1 
ATOM   1606 N NE  . ARG B 2 161 ? 28.50728 -26.98691 -28.12231 1.000 39.22342 ? 493 ARG B NE  1 
ATOM   1607 C CZ  . ARG B 2 161 ? 28.63560 -26.29258 -29.24453 1.000 43.75922 ? 493 ARG B CZ  1 
ATOM   1608 N NH1 . ARG B 2 161 ? 29.81226 -26.13527 -29.83004 1.000 41.41389 ? 493 ARG B NH1 1 
ATOM   1609 N NH2 . ARG B 2 161 ? 27.55765 -25.73395 -29.78801 1.000 40.32579 ? 493 ARG B NH2 1 
ATOM   1610 N N   . SER B 2 162 ? 28.52695 -23.89418 -24.74422 1.000 36.37932 ? 494 SER B N   1 
ATOM   1611 C CA  . SER B 2 162 ? 27.78240 -22.79616 -24.15169 1.000 39.61849 ? 494 SER B CA  1 
ATOM   1612 C C   . SER B 2 162 ? 26.28986 -23.10259 -24.15081 1.000 40.75347 ? 494 SER B C   1 
ATOM   1613 O O   . SER B 2 162 ? 25.78261 -23.82642 -25.00968 1.000 40.96213 ? 494 SER B O   1 
ATOM   1614 C CB  . SER B 2 162 ? 28.04751 -21.49332 -24.90038 1.000 40.73215 ? 494 SER B CB  1 
ATOM   1615 O OG  . SER B 2 162 ? 27.19115 -20.47728 -24.41820 1.000 45.06559 ? 494 SER B OG  1 
ATOM   1616 N N   . TYR B 2 163 ? 25.58529 -22.54552 -23.16531 1.000 36.06490 ? 495 TYR B N   1 
ATOM   1617 C CA  . TYR B 2 163 ? 24.15103 -22.79474 -23.06351 1.000 36.04190 ? 495 TYR B CA  1 
ATOM   1618 C C   . TYR B 2 163 ? 23.36760 -22.01462 -24.11348 1.000 37.99754 ? 495 TYR B C   1 
ATOM   1619 O O   . TYR B 2 163 ? 22.35818 -22.50707 -24.63273 1.000 38.02291 ? 495 TYR B O   1 
ATOM   1620 C CB  . TYR B 2 163 ? 23.65562 -22.44126 -21.66588 1.000 36.00557 ? 495 TYR B CB  1 
ATOM   1621 C CG  . TYR B 2 163 ? 23.87061 -23.51403 -20.62487 1.000 36.53660 ? 495 TYR B CG  1 
ATOM   1622 C CD1 . TYR B 2 163 ? 23.19960 -24.72809 -20.69939 1.000 31.58965 ? 495 TYR B CD1 1 
ATOM   1623 C CD2 . TYR B 2 163 ? 24.71805 -23.30049 -19.54617 1.000 34.56108 ? 495 TYR B CD2 1 
ATOM   1624 C CE1 . TYR B 2 163 ? 23.38395 -25.70381 -19.74129 1.000 37.21486 ? 495 TYR B CE1 1 
ATOM   1625 C CE2 . TYR B 2 163 ? 24.90603 -24.26676 -18.58708 1.000 33.39566 ? 495 TYR B CE2 1 
ATOM   1626 C CZ  . TYR B 2 163 ? 24.23498 -25.46744 -18.68317 1.000 34.43770 ? 495 TYR B CZ  1 
ATOM   1627 O OH  . TYR B 2 163 ? 24.42140 -26.43521 -17.71865 1.000 34.76316 ? 495 TYR B OH  1 
ATOM   1628 N N   . GLY B 2 164 ? 23.80041 -20.79623 -24.42495 1.000 37.44330 ? 496 GLY B N   1 
ATOM   1629 C CA  . GLY B 2 164 ? 23.10890 -19.99573 -25.42716 1.000 41.87495 ? 496 GLY B CA  1 
ATOM   1630 C C   . GLY B 2 164 ? 21.70024 -19.60435 -25.03609 1.000 44.89148 ? 496 GLY B C   1 
ATOM   1631 O O   . GLY B 2 164 ? 20.81588 -19.53934 -25.89866 1.000 39.88225 ? 496 GLY B O   1 
ATOM   1632 N N   . PHE B 2 165 ? 21.47698 -19.33143 -23.74830 1.000 38.51129 ? 497 PHE B N   1 
ATOM   1633 C CA  . PHE B 2 165 ? 20.13971 -19.05448 -23.23611 1.000 36.96300 ? 497 PHE B CA  1 
ATOM   1634 C C   . PHE B 2 165 ? 19.46289 -17.91436 -23.98801 1.000 40.37975 ? 497 PHE B C   1 
ATOM   1635 O O   . PHE B 2 165 ? 20.02961 -16.82805 -24.13814 1.000 38.52291 ? 497 PHE B O   1 
ATOM   1636 C CB  . PHE B 2 165 ? 20.21146 -18.70029 -21.74964 1.000 36.17319 ? 497 PHE B CB  1 
ATOM   1637 C CG  . PHE B 2 165 ? 20.62917 -19.83638 -20.86158 1.000 36.32361 ? 497 PHE B CG  1 
ATOM   1638 C CD1 . PHE B 2 165 ? 19.88284 -21.00284 -20.80241 1.000 38.92106 ? 497 PHE B CD1 1 
ATOM   1639 C CD2 . PHE B 2 165 ? 21.74387 -19.71480 -20.04362 1.000 40.35804 ? 497 PHE B CD2 1 
ATOM   1640 C CE1 . PHE B 2 165 ? 20.25374 -22.04323 -19.95687 1.000 41.47724 ? 497 PHE B CE1 1 
ATOM   1641 C CE2 . PHE B 2 165 ? 22.12074 -20.74537 -19.19453 1.000 35.78352 ? 497 PHE B CE2 1 
ATOM   1642 C CZ  . PHE B 2 165 ? 21.37313 -21.91335 -19.14998 1.000 34.49625 ? 497 PHE B CZ  1 
ATOM   1643 N N   . ARG B 2 166 ? 18.22906 -18.16042 -24.43153 1.000 43.60318 ? 498 ARG B N   1 
ATOM   1644 C CA  . ARG B 2 166 ? 17.38082 -17.16158 -25.06096 1.000 45.40362 ? 498 ARG B CA  1 
ATOM   1645 C C   . ARG B 2 166 ? 16.03481 -17.12193 -24.35186 1.000 40.00911 ? 498 ARG B C   1 
ATOM   1646 O O   . ARG B 2 166 ? 15.51694 -18.16964 -23.94456 1.000 45.23527 ? 498 ARG B O   1 
ATOM   1647 C CB  . ARG B 2 166 ? 17.16586 -17.46226 -26.55414 1.000 42.19668 ? 498 ARG B CB  1 
ATOM   1648 C CG  . ARG B 2 166 ? 18.44512 -17.63806 -27.34207 1.000 47.63883 ? 498 ARG B CG  1 
ATOM   1649 C CD  . ARG B 2 166 ? 18.16415 -17.65636 -28.83045 1.000 48.32565 ? 498 ARG B CD  1 
ATOM   1650 N NE  . ARG B 2 166 ? 19.36434 -17.92269 -29.61115 1.000 52.08984 ? 498 ARG B NE  1 
ATOM   1651 C CZ  . ARG B 2 166 ? 19.46370 -17.70825 -30.91629 1.000 58.36239 ? 498 ARG B CZ  1 
ATOM   1652 N NH1 . ARG B 2 166 ? 18.46525 -17.18244 -31.60664 1.000 55.29186 ? 498 ARG B NH1 1 
ATOM   1653 N NH2 . ARG B 2 166 ? 20.59350 -18.02602 -31.54336 1.000 54.07661 ? 498 ARG B NH2 1 
ATOM   1654 N N   . PRO B 2 167 ? 15.43584 -15.93691 -24.20362 1.000 45.72056 ? 499 PRO B N   1 
ATOM   1655 C CA  . PRO B 2 167 ? 14.17462 -15.84046 -23.44765 1.000 49.84679 ? 499 PRO B CA  1 
ATOM   1656 C C   . PRO B 2 167 ? 13.02599 -16.60431 -24.07416 1.000 50.50386 ? 499 PRO B C   1 
ATOM   1657 O O   . PRO B 2 167 ? 12.04360 -16.89246 -23.38015 1.000 53.01964 ? 499 PRO B O   1 
ATOM   1658 C CB  . PRO B 2 167 ? 13.89339 -14.33141 -23.42488 1.000 48.45881 ? 499 PRO B CB  1 
ATOM   1659 C CG  . PRO B 2 167 ? 14.61657 -13.79782 -24.62034 1.000 52.11742 ? 499 PRO B CG  1 
ATOM   1660 C CD  . PRO B 2 167 ? 15.86233 -14.63129 -24.73548 1.000 50.69742 ? 499 PRO B CD  1 
ATOM   1661 N N   . THR B 2 168 ? 13.11267 -16.93972 -25.35763 1.000 47.06298 ? 500 THR B N   1 
ATOM   1662 C CA  . THR B 2 168 ? 12.06299 -17.68833 -26.03249 1.000 51.23503 ? 500 THR B CA  1 
ATOM   1663 C C   . THR B 2 168 ? 12.11470 -19.18320 -25.73772 1.000 51.08609 ? 500 THR B C   1 
ATOM   1664 O O   . THR B 2 168 ? 11.23845 -19.91926 -26.20459 1.000 48.22503 ? 500 THR B O   1 
ATOM   1665 C CB  . THR B 2 168 ? 12.15327 -17.45308 -27.54386 1.000 49.18489 ? 500 THR B CB  1 
ATOM   1666 O OG1 . THR B 2 168 ? 13.22343 -18.23508 -28.08693 1.000 56.73740 ? 500 THR B OG1 1 
ATOM   1667 C CG2 . THR B 2 168 ? 12.43332 -15.98520 -27.82842 1.000 52.43451 ? 500 THR B CG2 1 
ATOM   1668 N N   . TYR B 2 169 ? 13.10379 -19.64689 -24.97652 1.000 46.49400 ? 501 TYR B N   1 
ATOM   1669 C CA  . TYR B 2 169 ? 13.24968 -21.07065 -24.71686 1.000 44.34370 ? 501 TYR B CA  1 
ATOM   1670 C C   . TYR B 2 169 ? 12.12928 -21.57850 -23.81490 1.000 45.59367 ? 501 TYR B C   1 
ATOM   1671 O O   . TYR B 2 169 ? 11.51154 -20.82510 -23.05722 1.000 45.07731 ? 501 TYR B O   1 
ATOM   1672 C CB  . TYR B 2 169 ? 14.60568 -21.36981 -24.06750 1.000 45.62273 ? 501 TYR B CB  1 
ATOM   1673 C CG  . TYR B 2 169 ? 15.77507 -21.31294 -25.02619 1.000 45.96284 ? 501 TYR B CG  1 
ATOM   1674 C CD1 . TYR B 2 169 ? 15.58475 -20.96055 -26.35571 1.000 47.25908 ? 501 TYR B CD1 1 
ATOM   1675 C CD2 . TYR B 2 169 ? 17.06422 -21.62648 -24.60854 1.000 46.22447 ? 501 TYR B CD2 1 
ATOM   1676 C CE1 . TYR B 2 169 ? 16.64019 -20.90910 -27.24488 1.000 45.90233 ? 501 TYR B CE1 1 
ATOM   1677 C CE2 . TYR B 2 169 ? 18.13408 -21.57796 -25.49676 1.000 42.26168 ? 501 TYR B CE2 1 
ATOM   1678 C CZ  . TYR B 2 169 ? 17.90930 -21.21971 -26.81403 1.000 46.44427 ? 501 TYR B CZ  1 
ATOM   1679 O OH  . TYR B 2 169 ? 18.95309 -21.16151 -27.70861 1.000 39.84346 ? 501 TYR B OH  1 
ATOM   1680 N N   . GLY B 2 170 ? 11.86516 -22.88060 -23.91302 1.000 40.80661 ? 502 GLY B N   1 
ATOM   1681 C CA  . GLY B 2 170 ? 11.02150 -23.52916 -22.93211 1.000 42.93714 ? 502 GLY B CA  1 
ATOM   1682 C C   . GLY B 2 170 ? 11.61123 -23.42517 -21.53881 1.000 43.96586 ? 502 GLY B C   1 
ATOM   1683 O O   . GLY B 2 170 ? 12.81110 -23.21355 -21.35665 1.000 42.27518 ? 502 GLY B O   1 
ATOM   1684 N N   . VAL B 2 171 ? 10.74137 -23.56859 -20.53610 1.000 38.25074 ? 503 VAL B N   1 
ATOM   1685 C CA  . VAL B 2 171 ? 11.17139 -23.35818 -19.15414 1.000 40.61236 ? 503 VAL B CA  1 
ATOM   1686 C C   . VAL B 2 171 ? 12.25427 -24.35554 -18.75937 1.000 40.06760 ? 503 VAL B C   1 
ATOM   1687 O O   . VAL B 2 171 ? 13.18007 -24.01359 -18.01249 1.000 44.10035 ? 503 VAL B O   1 
ATOM   1688 C CB  . VAL B 2 171 ? 9.95857  -23.41508 -18.20067 1.000 39.84741 ? 503 VAL B CB  1 
ATOM   1689 C CG1 . VAL B 2 171 ? 9.26557  -24.77130 -18.27213 1.000 45.65972 ? 503 VAL B CG1 1 
ATOM   1690 C CG2 . VAL B 2 171 ? 10.38393 -23.11130 -16.78046 1.000 45.71060 ? 503 VAL B CG2 1 
ATOM   1691 N N   . GLY B 2 172 ? 12.17792 -25.58856 -19.26702 1.000 39.90217 ? 504 GLY B N   1 
ATOM   1692 C CA  . GLY B 2 172 ? 13.19401 -26.58649 -18.97937 1.000 40.65210 ? 504 GLY B CA  1 
ATOM   1693 C C   . GLY B 2 172 ? 14.55357 -26.28235 -19.57729 1.000 43.37633 ? 504 GLY B C   1 
ATOM   1694 O O   . GLY B 2 172 ? 15.54686 -26.89955 -19.17698 1.000 44.46370 ? 504 GLY B O   1 
ATOM   1695 N N   . HIS B 2 173 ? 14.62066 -25.34898 -20.52354 1.000 39.94884 ? 505 HIS B N   1 
ATOM   1696 C CA  . HIS B 2 173 ? 15.87483 -24.92321 -21.12748 1.000 40.63376 ? 505 HIS B CA  1 
ATOM   1697 C C   . HIS B 2 173 ? 16.27373 -23.51418 -20.71627 1.000 39.56535 ? 505 HIS B C   1 
ATOM   1698 O O   . HIS B 2 173 ? 17.29940 -23.01042 -21.18838 1.000 40.02064 ? 505 HIS B O   1 
ATOM   1699 C CB  . HIS B 2 173 ? 15.78160 -25.00294 -22.65791 1.000 41.39769 ? 505 HIS B CB  1 
ATOM   1700 C CG  . HIS B 2 173 ? 15.65412 -26.39890 -23.18526 1.000 47.26322 ? 505 HIS B CG  1 
ATOM   1701 N ND1 . HIS B 2 173 ? 14.68712 -26.76617 -24.09624 1.000 50.08548 ? 505 HIS B ND1 1 
ATOM   1702 C CD2 . HIS B 2 173 ? 16.37630 -27.51679 -22.93369 1.000 49.81863 ? 505 HIS B CD2 1 
ATOM   1703 C CE1 . HIS B 2 173 ? 14.81585 -28.05030 -24.37955 1.000 48.22475 ? 505 HIS B CE1 1 
ATOM   1704 N NE2 . HIS B 2 173 ? 15.83375 -28.52950 -23.68757 1.000 45.50066 ? 505 HIS B NE2 1 
ATOM   1705 N N   . GLN B 2 174 ? 15.48538 -22.85912 -19.87204 1.000 37.59577 ? 506 GLN B N   1 
ATOM   1706 C CA  . GLN B 2 174 ? 15.80269 -21.51966 -19.40971 1.000 38.59256 ? 506 GLN B CA  1 
ATOM   1707 C C   . GLN B 2 174 ? 16.86167 -21.57746 -18.31256 1.000 39.14743 ? 506 GLN B C   1 
ATOM   1708 O O   . GLN B 2 174 ? 17.02123 -22.60294 -17.64778 1.000 34.56516 ? 506 GLN B O   1 
ATOM   1709 C CB  . GLN B 2 174 ? 14.53776 -20.83066 -18.90128 1.000 36.80192 ? 506 GLN B CB  1 
ATOM   1710 C CG  . GLN B 2 174 ? 13.59626 -20.40397 -20.01572 1.000 44.59579 ? 506 GLN B CG  1 
ATOM   1711 C CD  . GLN B 2 174 ? 12.35617 -19.69559 -19.51353 1.000 48.09103 ? 506 GLN B CD  1 
ATOM   1712 O OE1 . GLN B 2 174 ? 12.22069 -19.41588 -18.32178 1.000 44.57108 ? 506 GLN B OE1 1 
ATOM   1713 N NE2 . GLN B 2 174 ? 11.43751 -19.40143 -20.42747 1.000 46.32042 ? 506 GLN B NE2 1 
ATOM   1714 N N   . PRO B 2 175 ? 17.61363 -20.49376 -18.11491 1.000 35.81930 ? 507 PRO B N   1 
ATOM   1715 C CA  . PRO B 2 175 ? 18.64759 -20.50661 -17.07642 1.000 35.93255 ? 507 PRO B CA  1 
ATOM   1716 C C   . PRO B 2 175 ? 18.02983 -20.47303 -15.69178 1.000 36.75209 ? 507 PRO B C   1 
ATOM   1717 O O   . PRO B 2 175 ? 17.01054 -19.81684 -15.46094 1.000 35.75441 ? 507 PRO B O   1 
ATOM   1718 C CB  . PRO B 2 175 ? 19.45191 -19.23271 -17.35560 1.000 39.38382 ? 507 PRO B CB  1 
ATOM   1719 C CG  . PRO B 2 175 ? 18.48396 -18.32526 -18.03763 1.000 40.94793 ? 507 PRO B CG  1 
ATOM   1720 C CD  . PRO B 2 175 ? 17.58028 -19.21320 -18.84412 1.000 40.62515 ? 507 PRO B CD  1 
ATOM   1721 N N   . TYR B 2 176 ? 18.65304 -21.20729 -14.77345 1.000 37.87905 ? 508 TYR B N   1 
ATOM   1722 C CA  . TYR B 2 176 ? 18.31275 -21.16649 -13.35771 1.000 34.22667 ? 508 TYR B CA  1 
ATOM   1723 C C   . TYR B 2 176 ? 19.58061 -20.87974 -12.57390 1.000 35.19163 ? 508 TYR B C   1 
ATOM   1724 O O   . TYR B 2 176 ? 20.62689 -21.48136 -12.83596 1.000 32.77880 ? 508 TYR B O   1 
ATOM   1725 C CB  . TYR B 2 176 ? 17.67896 -22.48173 -12.88272 1.000 30.54249 ? 508 TYR B CB  1 
ATOM   1726 C CG  . TYR B 2 176 ? 16.20890 -22.58087 -13.21805 1.000 41.00915 ? 508 TYR B CG  1 
ATOM   1727 C CD1 . TYR B 2 176 ? 15.78373 -22.62852 -14.54450 1.000 39.59231 ? 508 TYR B CD1 1 
ATOM   1728 C CD2 . TYR B 2 176 ? 15.24575 -22.61477 -12.21751 1.000 38.16476 ? 508 TYR B CD2 1 
ATOM   1729 C CE1 . TYR B 2 176 ? 14.44445 -22.71167 -14.86288 1.000 41.79776 ? 508 TYR B CE1 1 
ATOM   1730 C CE2 . TYR B 2 176 ? 13.89941 -22.70044 -12.52645 1.000 44.93239 ? 508 TYR B CE2 1 
ATOM   1731 C CZ  . TYR B 2 176 ? 13.50670 -22.74407 -13.85279 1.000 43.39855 ? 508 TYR B CZ  1 
ATOM   1732 O OH  . TYR B 2 176 ? 12.17275 -22.82748 -14.17582 1.000 47.30605 ? 508 TYR B OH  1 
ATOM   1733 N N   . ARG B 2 177 ? 19.49357 -19.95066 -11.63297 1.000 38.70667 ? 509 ARG B N   1 
ATOM   1734 C CA  . ARG B 2 177 ? 20.59365 -19.69049 -10.71815 1.000 39.36785 ? 509 ARG B CA  1 
ATOM   1735 C C   . ARG B 2 177 ? 20.45580 -20.60720 -9.51331  1.000 40.63512 ? 509 ARG B C   1 
ATOM   1736 O O   . ARG B 2 177 ? 19.36231 -20.74895 -8.95855  1.000 38.72993 ? 509 ARG B O   1 
ATOM   1737 C CB  . ARG B 2 177 ? 20.60862 -18.22341 -10.29515 1.000 40.43470 ? 509 ARG B CB  1 
ATOM   1738 C CG  . ARG B 2 177 ? 21.01671 -17.30366 -11.41817 1.000 43.75145 ? 509 ARG B CG  1 
ATOM   1739 C CD  . ARG B 2 177 ? 21.06206 -15.84973 -11.00175 1.000 41.40283 ? 509 ARG B CD  1 
ATOM   1740 N NE  . ARG B 2 177 ? 21.66946 -15.04135 -12.05285 1.000 47.37859 ? 509 ARG B NE  1 
ATOM   1741 C CZ  . ARG B 2 177 ? 22.03309 -13.77501 -11.91142 1.000 49.32500 ? 509 ARG B CZ  1 
ATOM   1742 N NH1 . ARG B 2 177 ? 21.83930 -13.12277 -10.77617 1.000 42.44356 ? 509 ARG B NH1 1 
ATOM   1743 N NH2 . ARG B 2 177 ? 22.61569 -13.15149 -12.93029 1.000 45.20607 ? 509 ARG B NH2 1 
ATOM   1744 N N   . VAL B 2 178 ? 21.55876 -21.24990 -9.13609  1.000 33.48633 ? 510 VAL B N   1 
ATOM   1745 C CA  . VAL B 2 178 ? 21.58423 -22.23629 -8.06717  1.000 35.45898 ? 510 VAL B CA  1 
ATOM   1746 C C   . VAL B 2 178 ? 22.56223 -21.75983 -7.00575  1.000 35.48566 ? 510 VAL B C   1 
ATOM   1747 O O   . VAL B 2 178 ? 23.65106 -21.26921 -7.32513  1.000 33.59701 ? 510 VAL B O   1 
ATOM   1748 C CB  . VAL B 2 178 ? 21.98301 -23.63857 -8.57778  1.000 36.38884 ? 510 VAL B CB  1 
ATOM   1749 C CG1 . VAL B 2 178 ? 21.95652 -24.65277 -7.43913  1.000 31.79924 ? 510 VAL B CG1 1 
ATOM   1750 C CG2 . VAL B 2 178 ? 21.06916 -24.07776 -9.70616  1.000 33.96616 ? 510 VAL B CG2 1 
ATOM   1751 N N   . VAL B 2 179 ? 22.16530 -21.89093 -5.74554  1.000 35.50576 ? 511 VAL B N   1 
ATOM   1752 C CA  . VAL B 2 179 ? 23.04484 -21.64946 -4.60856  1.000 37.25135 ? 511 VAL B CA  1 
ATOM   1753 C C   . VAL B 2 179 ? 23.02084 -22.90191 -3.74779  1.000 32.97902 ? 511 VAL B C   1 
ATOM   1754 O O   . VAL B 2 179 ? 21.94380 -23.38553 -3.37628  1.000 36.04054 ? 511 VAL B O   1 
ATOM   1755 C CB  . VAL B 2 179 ? 22.62523 -20.41155 -3.80167  1.000 39.37633 ? 511 VAL B CB  1 
ATOM   1756 C CG1 . VAL B 2 179 ? 23.46617 -20.29328 -2.52797  1.000 33.59688 ? 511 VAL B CG1 1 
ATOM   1757 C CG2 . VAL B 2 179 ? 22.77575 -19.16080 -4.63675  1.000 35.17603 ? 511 VAL B CG2 1 
ATOM   1758 N N   . VAL B 2 180 ? 24.19806 -23.45263 -3.47048  1.000 30.37448 ? 512 VAL B N   1 
ATOM   1759 C CA  . VAL B 2 180 ? 24.33737 -24.62326 -2.61483  1.000 32.23687 ? 512 VAL B CA  1 
ATOM   1760 C C   . VAL B 2 180 ? 25.01268 -24.16577 -1.33028  1.000 34.13710 ? 512 VAL B C   1 
ATOM   1761 O O   . VAL B 2 180 ? 26.14899 -23.67401 -1.35939  1.000 34.66710 ? 512 VAL B O   1 
ATOM   1762 C CB  . VAL B 2 180 ? 25.13970 -25.74370 -3.29253  1.000 32.83423 ? 512 VAL B CB  1 
ATOM   1763 C CG1 . VAL B 2 180 ? 25.21150 -26.96523 -2.38115  1.000 34.41002 ? 512 VAL B CG1 1 
ATOM   1764 C CG2 . VAL B 2 180 ? 24.52591 -26.11044 -4.64844  1.000 31.83659 ? 512 VAL B CG2 1 
ATOM   1765 N N   . LEU B 2 181 ? 24.31189 -24.31371 -0.21010  1.000 34.62345 ? 513 LEU B N   1 
ATOM   1766 C CA  . LEU B 2 181 ? 24.82976 -23.93462 1.09814   1.000 37.43759 ? 513 LEU B CA  1 
ATOM   1767 C C   . LEU B 2 181 ? 25.33127 -25.18345 1.80610   1.000 34.21920 ? 513 LEU B C   1 
ATOM   1768 O O   . LEU B 2 181 ? 24.56470 -26.12632 2.01978   1.000 36.52361 ? 513 LEU B O   1 
ATOM   1769 C CB  . LEU B 2 181 ? 23.75456 -23.24427 1.93774   1.000 38.17700 ? 513 LEU B CB  1 
ATOM   1770 C CG  . LEU B 2 181 ? 23.23475 -21.91941 1.38084   1.000 39.28076 ? 513 LEU B CG  1 
ATOM   1771 C CD1 . LEU B 2 181 ? 22.22120 -21.29631 2.32546   1.000 36.93303 ? 513 LEU B CD1 1 
ATOM   1772 C CD2 . LEU B 2 181 ? 24.38681 -20.96505 1.10971   1.000 37.62086 ? 513 LEU B CD2 1 
ATOM   1773 N N   . SER B 2 182 ? 26.61505 -25.19575 2.14744   1.000 35.78691 ? 514 SER B N   1 
ATOM   1774 C CA  . SER B 2 182 ? 27.20641 -26.25166 2.95514   1.000 36.57056 ? 514 SER B CA  1 
ATOM   1775 C C   . SER B 2 182 ? 27.38622 -25.73153 4.37509   1.000 34.36115 ? 514 SER B C   1 
ATOM   1776 O O   . SER B 2 182 ? 27.95587 -24.65417 4.57300   1.000 36.08441 ? 514 SER B O   1 
ATOM   1777 C CB  . SER B 2 182 ? 28.55099 -26.69943 2.37939   1.000 36.31546 ? 514 SER B CB  1 
ATOM   1778 O OG  . SER B 2 182 ? 28.37522 -27.53588 1.25408   1.000 43.00638 ? 514 SER B OG  1 
ATOM   1779 N N   . PHE B 2 183 ? 26.88265 -26.48255 5.35391   1.000 36.02891 ? 515 PHE B N   1 
ATOM   1780 C CA  . PHE B 2 183 ? 26.92972 -26.09064 6.76335   1.000 39.63576 ? 515 PHE B CA  1 
ATOM   1781 C C   . PHE B 2 183 ? 27.93371 -26.98445 7.47985   1.000 37.17768 ? 515 PHE B C   1 
ATOM   1782 O O   . PHE B 2 183 ? 27.66530 -28.16702 7.71552   1.000 41.70876 ? 515 PHE B O   1 
ATOM   1783 C CB  . PHE B 2 183 ? 25.54820 -26.18561 7.40678   1.000 39.62388 ? 515 PHE B CB  1 
ATOM   1784 C CG  . PHE B 2 183 ? 24.54472 -25.23314 6.82135   1.000 36.24333 ? 515 PHE B CG  1 
ATOM   1785 C CD1 . PHE B 2 183 ? 24.66634 -23.86765 7.02449   1.000 39.90784 ? 515 PHE B CD1 1 
ATOM   1786 C CD2 . PHE B 2 183 ? 23.48010 -25.70026 6.07023   1.000 41.75530 ? 515 PHE B CD2 1 
ATOM   1787 C CE1 . PHE B 2 183 ? 23.74815 -22.98291 6.48449   1.000 48.45237 ? 515 PHE B CE1 1 
ATOM   1788 C CE2 . PHE B 2 183 ? 22.55743 -24.82079 5.52693   1.000 43.86924 ? 515 PHE B CE2 1 
ATOM   1789 C CZ  . PHE B 2 183 ? 22.69237 -23.46099 5.73236   1.000 41.81476 ? 515 PHE B CZ  1 
ATOM   1790 N N   . GLU B 2 184 ? 29.08087 -26.41539 7.83383   1.000 36.35596 ? 516 GLU B N   1 
ATOM   1791 C CA  . GLU B 2 184 ? 30.21111 -27.17422 8.34875   1.000 35.36194 ? 516 GLU B CA  1 
ATOM   1792 C C   . GLU B 2 184 ? 30.31402 -26.99299 9.85784   1.000 32.98136 ? 516 GLU B C   1 
ATOM   1793 O O   . GLU B 2 184 ? 30.34938 -25.86061 10.34831  1.000 36.60839 ? 516 GLU B O   1 
ATOM   1794 C CB  . GLU B 2 184 ? 31.50508 -26.71796 7.67761   1.000 41.79222 ? 516 GLU B CB  1 
ATOM   1795 C CG  . GLU B 2 184 ? 32.69614 -27.62511 7.91140   1.000 46.97090 ? 516 GLU B CG  1 
ATOM   1796 C CD  . GLU B 2 184 ? 33.93693 -27.12496 7.19553   1.000 52.89793 ? 516 GLU B CD  1 
ATOM   1797 O OE1 . GLU B 2 184 ? 34.18001 -25.89800 7.21630   1.000 52.39278 ? 516 GLU B OE1 1 
ATOM   1798 O OE2 . GLU B 2 184 ? 34.66007 -27.95337 6.60187   1.000 61.77648 ? 516 GLU B OE2 1 
ATOM   1799 N N   . LEU B 2 185 ? 30.36976 -28.10437 10.58300  1.000 33.48619 ? 517 LEU B N   1 
ATOM   1800 C CA  . LEU B 2 185 ? 30.57270 -28.09444 12.03259  1.000 40.12076 ? 517 LEU B CA  1 
ATOM   1801 C C   . LEU B 2 185 ? 31.82352 -28.91488 12.33807  1.000 38.39155 ? 517 LEU B C   1 
ATOM   1802 O O   . LEU B 2 185 ? 31.77477 -30.14784 12.38485  1.000 43.88731 ? 517 LEU B O   1 
ATOM   1803 C CB  . LEU B 2 185 ? 29.35158 -28.64004 12.76520  1.000 38.13622 ? 517 LEU B CB  1 
ATOM   1804 C CG  . LEU B 2 185 ? 29.35879 -28.44253 14.28287  1.000 54.51438 ? 517 LEU B CG  1 
ATOM   1805 C CD1 . LEU B 2 185 ? 29.37661 -26.95727 14.63413  1.000 49.91135 ? 517 LEU B CD1 1 
ATOM   1806 C CD2 . LEU B 2 185 ? 28.16944 -29.13951 14.92615  1.000 57.47809 ? 517 LEU B CD2 1 
ATOM   1807 N N   . LEU B 2 186 ? 32.94602 -28.23167 12.53154  1.000 35.44865 ? 518 LEU B N   1 
ATOM   1808 C CA  . LEU B 2 186 ? 34.18684 -28.87677 12.92254  1.000 37.02523 ? 518 LEU B CA  1 
ATOM   1809 C C   . LEU B 2 186 ? 34.28749 -28.90510 14.44744  1.000 40.74538 ? 518 LEU B C   1 
ATOM   1810 O O   . LEU B 2 186 ? 33.40485 -28.42472 15.16169  1.000 41.17132 ? 518 LEU B O   1 
ATOM   1811 C CB  . LEU B 2 186 ? 35.38115 -28.14631 12.31666  1.000 37.70875 ? 518 LEU B CB  1 
ATOM   1812 C CG  . LEU B 2 186 ? 35.30423 -27.83613 10.82017  1.000 37.96749 ? 518 LEU B CG  1 
ATOM   1813 C CD1 . LEU B 2 186 ? 36.48654 -26.97841 10.40321  1.000 36.27007 ? 518 LEU B CD1 1 
ATOM   1814 C CD2 . LEU B 2 186 ? 35.25278 -29.12234 10.01404  1.000 43.38370 ? 518 LEU B CD2 1 
ATOM   1815 N N   . HIS B 2 187 ? 35.37960 -29.48016 14.95496  1.000 38.35323 ? 519 HIS B N   1 
ATOM   1816 C CA  . HIS B 2 187 ? 35.70246 -29.41010 16.38305  1.000 37.25463 ? 519 HIS B CA  1 
ATOM   1817 C C   . HIS B 2 187 ? 36.37735 -28.06556 16.65418  1.000 38.78433 ? 519 HIS B C   1 
ATOM   1818 O O   . HIS B 2 187 ? 37.59165 -27.96273 16.84064  1.000 42.31324 ? 519 HIS B O   1 
ATOM   1819 C CB  . HIS B 2 187 ? 36.59628 -30.57073 16.79500  1.000 32.10443 ? 519 HIS B CB  1 
ATOM   1820 C CG  . HIS B 2 187 ? 35.96791 -31.91652 16.61890  1.000 36.67915 ? 519 HIS B CG  1 
ATOM   1821 N ND1 . HIS B 2 187 ? 34.68695 -32.08511 16.13928  1.000 45.76528 ? 519 HIS B ND1 1 
ATOM   1822 C CD2 . HIS B 2 187 ? 36.44316 -33.16049 16.86383  1.000 42.13735 ? 519 HIS B CD2 1 
ATOM   1823 C CE1 . HIS B 2 187 ? 34.40071 -33.37425 16.09269  1.000 42.61655 ? 519 HIS B CE1 1 
ATOM   1824 N NE2 . HIS B 2 187 ? 35.45058 -34.04889 16.52462  1.000 48.31233 ? 519 HIS B NE2 1 
ATOM   1825 N N   . ALA B 2 188 ? 35.55963 -27.01715 16.66585  1.000 38.72041 ? 520 ALA B N   1 
ATOM   1826 C CA  . ALA B 2 188 ? 36.06747 -25.65245 16.62441  1.000 40.43099 ? 520 ALA B CA  1 
ATOM   1827 C C   . ALA B 2 188 ? 34.92446 -24.70231 16.94908  1.000 39.14758 ? 520 ALA B C   1 
ATOM   1828 O O   . ALA B 2 188 ? 33.75043 -25.10464 16.93829  1.000 41.56514 ? 520 ALA B O   1 
ATOM   1829 C CB  . ALA B 2 188 ? 36.67595 -25.33255 15.24440  1.000 38.37690 ? 520 ALA B CB  1 
ATOM   1830 N N   . PRO B 2 189 ? 35.22493 -23.43178 17.23914  1.000 37.09649 ? 521 PRO B N   1 
ATOM   1831 C CA  . PRO B 2 189 ? 34.15990 -22.46088 17.51691  1.000 42.56739 ? 521 PRO B CA  1 
ATOM   1832 C C   . PRO B 2 189 ? 33.22825 -22.26388 16.32889  1.000 48.00930 ? 521 PRO B C   1 
ATOM   1833 O O   . PRO B 2 189 ? 33.64925 -22.27941 15.16995  1.000 41.87403 ? 521 PRO B O   1 
ATOM   1834 C CB  . PRO B 2 189 ? 34.92833 -21.17451 17.83630  1.000 39.30807 ? 521 PRO B CB  1 
ATOM   1835 C CG  . PRO B 2 189 ? 36.23877 -21.64129 18.35165  1.000 39.04943 ? 521 PRO B CG  1 
ATOM   1836 C CD  . PRO B 2 189 ? 36.55435 -22.89990 17.59890  1.000 43.58087 ? 521 PRO B CD  1 
ATOM   1837 N N   . ALA B 2 190 ? 31.94920 -22.05611 16.63520  1.000 47.34409 ? 522 ALA B N   1 
ATOM   1838 C CA  . ALA B 2 190 ? 30.91779 -21.81816 15.62950  1.000 48.68310 ? 522 ALA B CA  1 
ATOM   1839 C C   . ALA B 2 190 ? 30.68885 -20.31354 15.51635  1.000 51.87837 ? 522 ALA B C   1 
ATOM   1840 O O   . ALA B 2 190 ? 30.04790 -19.71170 16.38383  1.000 56.44497 ? 522 ALA B O   1 
ATOM   1841 C CB  . ALA B 2 190 ? 29.62817 -22.54731 15.99952  1.000 47.27353 ? 522 ALA B CB  1 
ATOM   1842 N N   . THR B 2 191 ? 31.21280 -19.70862 14.45039  1.000 45.06114 ? 523 THR B N   1 
ATOM   1843 C CA  . THR B 2 191 ? 31.16693 -18.26314 14.25938  1.000 50.28852 ? 523 THR B CA  1 
ATOM   1844 C C   . THR B 2 191 ? 30.12485 -17.82244 13.23838  1.000 51.36885 ? 523 THR B C   1 
ATOM   1845 O O   . THR B 2 191 ? 30.01842 -16.62264 12.96169  1.000 50.32406 ? 523 THR B O   1 
ATOM   1846 C CB  . THR B 2 191 ? 32.54304 -17.73732 13.83065  1.000 53.07559 ? 523 THR B CB  1 
ATOM   1847 O OG1 . THR B 2 191 ? 32.77657 -18.06122 12.45253  1.000 58.59455 ? 523 THR B OG1 1 
ATOM   1848 C CG2 . THR B 2 191 ? 33.63913 -18.35192 14.68463  1.000 56.82918 ? 523 THR B CG2 1 
ATOM   1849 N N   . VAL B 2 192 ? 29.37418 -18.75135 12.65763  1.000 46.78380 ? 524 VAL B N   1 
ATOM   1850 C CA  . VAL B 2 192 ? 28.27681 -18.42249 11.75727  1.000 49.33189 ? 524 VAL B CA  1 
ATOM   1851 C C   . VAL B 2 192 ? 26.99929 -18.85199 12.46200  1.000 44.58703 ? 524 VAL B C   1 
ATOM   1852 O O   . VAL B 2 192 ? 26.68285 -20.04547 12.52894  1.000 42.24958 ? 524 VAL B O   1 
ATOM   1853 C CB  . VAL B 2 192 ? 28.42051 -19.10029 10.39016  1.000 48.79649 ? 524 VAL B CB  1 
ATOM   1854 C CG1 . VAL B 2 192 ? 27.48614 -18.45031 9.38034   1.000 43.03955 ? 524 VAL B CG1 1 
ATOM   1855 C CG2 . VAL B 2 192 ? 29.85641 -19.02930 9.91727   1.000 48.16797 ? 524 VAL B CG2 1 
ATOM   1856 N N   . CYS B 2 193 ? 26.26649 -17.88258 12.99968  1.000 50.31769 ? 525 CYS B N   1 
ATOM   1857 C CA  . CYS B 2 193 ? 25.05967 -18.14398 13.76998  1.000 56.73379 ? 525 CYS B CA  1 
ATOM   1858 C C   . CYS B 2 193 ? 23.88075 -17.40771 13.15566  1.000 51.26588 ? 525 CYS B C   1 
ATOM   1859 O O   . CYS B 2 193 ? 24.02502 -16.28180 12.66948  1.000 54.38815 ? 525 CYS B O   1 
ATOM   1860 C CB  . CYS B 2 193 ? 25.22219 -17.70831 15.23083  1.000 55.55768 ? 525 CYS B CB  1 
ATOM   1861 S SG  . CYS B 2 193 ? 26.39650 -18.67217 16.21490  1.000 58.54262 ? 525 CYS B SG  1 
ATOM   1862 N N   . GLY B 2 194 ? 22.71492 -18.04573 13.19012  1.000 53.19474 ? 526 GLY B N   1 
ATOM   1863 C CA  . GLY B 2 194 ? 21.50615 -17.38267 12.75753  1.000 63.91009 ? 526 GLY B CA  1 
ATOM   1864 C C   . GLY B 2 194 ? 21.12404 -16.23526 13.67299  1.000 64.57700 ? 526 GLY B C   1 
ATOM   1865 O O   . GLY B 2 194 ? 21.57688 -16.12726 14.81463  1.000 63.41589 ? 526 GLY B O   1 
ATOM   1866 N N   . SER B 2 195 ? 20.26209 -15.35751 13.15210  1.000 65.68204 ? 527 SER B N   1 
ATOM   1867 C CA  . SER B 2 195 ? 19.81869 -14.18751 13.90382  1.000 67.54084 ? 527 SER B CA  1 
ATOM   1868 C C   . SER B 2 195 ? 19.06936 -14.54490 15.18051  1.000 65.18307 ? 527 SER B C   1 
ATOM   1869 O O   . SER B 2 195 ? 18.83234 -13.65552 16.00492  1.000 63.98794 ? 527 SER B O   1 
ATOM   1870 C CB  . SER B 2 195 ? 18.92936 -13.30129 13.02791  1.000 66.81589 ? 527 SER B CB  1 
ATOM   1871 O OG  . SER B 2 195 ? 19.70168 -12.51557 12.13842  1.000 74.26415 ? 527 SER B OG  1 
ATOM   1872 N N   . ASN B 2 196 ? 18.68794 -15.80413 15.36439  1.000 63.81130 ? 528 ASN B N   1 
ATOM   1873 C CA  . ASN B 2 196 ? 17.97226 -16.20946 16.56565  1.000 70.47078 ? 528 ASN B CA  1 
ATOM   1874 C C   . ASN B 2 196 ? 18.83846 -17.12834 17.42528  1.000 70.53171 ? 528 ASN B C   1 
ATOM   1875 O O   . ASN B 2 196 ? 18.43365 -18.23785 17.77390  1.000 70.31002 ? 528 ASN B O   1 
ATOM   1876 C CB  . ASN B 2 196 ? 16.65918 -16.90278 16.19554  1.000 73.02317 ? 528 ASN B CB  1 
ATOM   1877 C CG  . ASN B 2 196 ? 15.65802 -16.90119 17.33326  1.000 75.98956 ? 528 ASN B CG  1 
ATOM   1878 O OD1 . ASN B 2 196 ? 15.68729 -16.02795 18.20203  1.000 71.15339 ? 528 ASN B OD1 1 
ATOM   1879 N ND2 . ASN B 2 196 ? 14.76194 -17.88144 17.33230  1.000 81.07397 ? 528 ASN B ND2 1 
HETATM 1880 C C1  . GOL C 3 .   ? 23.32422 -24.44237 -27.56223 1.000 47.04928 ? 601 GOL B C1  1 
HETATM 1881 O O1  . GOL C 3 .   ? 23.26503 -23.23160 -28.25610 1.000 51.87879 ? 601 GOL B O1  1 
HETATM 1882 C C2  . GOL C 3 .   ? 24.74801 -25.02698 -27.75379 1.000 45.22592 ? 601 GOL B C2  1 
HETATM 1883 O O2  . GOL C 3 .   ? 25.00167 -25.38354 -29.06754 1.000 47.42058 ? 601 GOL B O2  1 
HETATM 1884 C C3  . GOL C 3 .   ? 24.79227 -26.25018 -26.82038 1.000 46.63402 ? 601 GOL B C3  1 
HETATM 1885 O O3  . GOL C 3 .   ? 25.92717 -26.97482 -27.17100 1.000 49.52690 ? 601 GOL B O3  1 
HETATM 1886 O O   . HOH D 4 .   ? 13.35503 -22.17924 -28.98643 1.000 48.27551 ? 101 HOH A O   1 
HETATM 1887 O O   . HOH D 4 .   ? 23.66666 -50.52673 -26.49899 1.000 63.75852 ? 102 HOH A O   1 
HETATM 1888 O O   . HOH D 4 .   ? 35.47457 -29.47039 -31.18578 1.000 39.24628 ? 103 HOH A O   1 
HETATM 1889 O O   . HOH D 4 .   ? 17.95699 -24.40984 -40.50764 1.000 40.29107 ? 104 HOH A O   1 
HETATM 1890 O O   . HOH D 4 .   ? 23.71429 -31.50316 -22.40949 1.000 36.39826 ? 105 HOH A O   1 
HETATM 1891 O O   . HOH D 4 .   ? 16.91103 -33.27603 -23.92758 1.000 48.45793 ? 106 HOH A O   1 
HETATM 1892 O O   . HOH D 4 .   ? 20.29022 -26.55436 -42.75633 1.000 52.55835 ? 107 HOH A O   1 
HETATM 1893 O O   . HOH D 4 .   ? 14.52193 -22.62340 -34.08639 1.000 48.12497 ? 108 HOH A O   1 
HETATM 1894 O O   . HOH D 4 .   ? 24.04032 -41.40903 -16.51885 1.000 49.61298 ? 109 HOH A O   1 
HETATM 1895 O O   . HOH D 4 .   ? 20.44782 -31.72872 -19.60185 1.000 36.27158 ? 110 HOH A O   1 
HETATM 1896 O O   . HOH D 4 .   ? 32.58753 -27.89499 -28.76206 1.000 54.67600 ? 111 HOH A O   1 
HETATM 1897 O O   . HOH D 4 .   ? 17.99437 -35.70768 -25.92666 1.000 42.67817 ? 112 HOH A O   1 
HETATM 1898 O O   . HOH D 4 .   ? 25.20335 -23.75411 -41.22949 1.000 56.03651 ? 113 HOH A O   1 
HETATM 1899 O O   . HOH D 4 .   ? 15.60022 -25.18415 -31.53531 1.000 45.67658 ? 114 HOH A O   1 
HETATM 1900 O O   . HOH D 4 .   ? 26.26838 -34.13914 -39.21844 1.000 40.85307 ? 115 HOH A O   1 
HETATM 1901 O O   . HOH D 4 .   ? 28.26017 -29.28679 -40.66905 1.000 53.52016 ? 116 HOH A O   1 
HETATM 1902 O O   . HOH D 4 .   ? 16.93480 -39.80688 -23.48574 1.000 54.41706 ? 117 HOH A O   1 
HETATM 1903 O O   . HOH D 4 .   ? 33.12952 -26.85006 -33.31352 1.000 52.75128 ? 118 HOH A O   1 
HETATM 1904 O O   . HOH D 4 .   ? 22.44960 -34.97674 -20.64296 1.000 46.58996 ? 119 HOH A O   1 
HETATM 1905 O O   . HOH D 4 .   ? 20.93735 -37.02033 -21.28683 1.000 50.01330 ? 120 HOH A O   1 
HETATM 1906 O O   . HOH D 4 .   ? 28.81839 -28.24060 -38.00841 1.000 44.49598 ? 121 HOH A O   1 
HETATM 1907 O O   . HOH D 4 .   ? 15.90129 -22.49159 -30.45938 1.000 42.43326 ? 122 HOH A O   1 
HETATM 1908 O O   . HOH D 4 .   ? 18.21552 -38.44644 -26.07231 1.000 51.10399 ? 123 HOH A O   1 
HETATM 1909 O O   . HOH E 4 .   ? 51.08834 -36.06366 -29.21197 1.000 47.04657 ? 701 HOH B O   1 
HETATM 1910 O O   . HOH E 4 .   ? 33.09497 -40.03436 -19.48534 1.000 47.44517 ? 702 HOH B O   1 
HETATM 1911 O O   . HOH E 4 .   ? 27.87135 -38.60630 -10.88322 1.000 40.56327 ? 703 HOH B O   1 
HETATM 1912 O O   . HOH E 4 .   ? 15.16144 -32.43028 -14.11817 1.000 37.30472 ? 704 HOH B O   1 
HETATM 1913 O O   . HOH E 4 .   ? 10.42418 -22.72207 -12.53876 1.000 46.48881 ? 705 HOH B O   1 
HETATM 1914 O O   . HOH E 4 .   ? 20.77231 -22.55906 -26.98973 1.000 46.75274 ? 706 HOH B O   1 
HETATM 1915 O O   . HOH E 4 .   ? 44.95473 -36.48426 -27.08685 1.000 45.22900 ? 707 HOH B O   1 
HETATM 1916 O O   . HOH E 4 .   ? 38.46334 -36.17581 -19.37250 1.000 46.77048 ? 708 HOH B O   1 
HETATM 1917 O O   . HOH E 4 .   ? 33.70857 -28.35406 -12.54615 1.000 32.34769 ? 709 HOH B O   1 
HETATM 1918 O O   . HOH E 4 .   ? 19.95888 -39.32513 -11.36908 1.000 53.17055 ? 710 HOH B O   1 
HETATM 1919 O O   . HOH E 4 .   ? 41.69932 -26.96420 -32.39189 1.000 58.19641 ? 711 HOH B O   1 
HETATM 1920 O O   . HOH E 4 .   ? 12.77885 -16.58914 -10.46903 1.000 48.68345 ? 712 HOH B O   1 
HETATM 1921 O O   . HOH E 4 .   ? 11.77078 -19.28043 -9.76226  1.000 47.79306 ? 713 HOH B O   1 
HETATM 1922 O O   . HOH E 4 .   ? 19.76981 -11.28914 15.59678  1.000 61.41423 ? 714 HOH B O   1 
HETATM 1923 O O   . HOH E 4 .   ? 26.19581 -37.99000 -4.41796  1.000 48.28484 ? 715 HOH B O   1 
HETATM 1924 O O   . HOH E 4 .   ? 23.41233 -34.28541 6.09437   1.000 51.43351 ? 716 HOH B O   1 
HETATM 1925 O O   . HOH E 4 .   ? 29.22248 -18.45175 -4.65402  1.000 36.22828 ? 717 HOH B O   1 
HETATM 1926 O O   . HOH E 4 .   ? 41.28549 -39.24297 -30.95924 1.000 49.61234 ? 718 HOH B O   1 
HETATM 1927 O O   . HOH E 4 .   ? 23.20882 -36.08269 2.09767   1.000 52.94199 ? 719 HOH B O   1 
HETATM 1928 O O   . HOH E 4 .   ? 33.81746 -29.52787 -15.25531 1.000 34.26209 ? 720 HOH B O   1 
HETATM 1929 O O   . HOH E 4 .   ? 38.78955 -32.62909 -18.20061 1.000 44.15964 ? 721 HOH B O   1 
HETATM 1930 O O   . HOH E 4 .   ? 17.76028 -35.60062 -12.13540 1.000 45.95639 ? 722 HOH B O   1 
HETATM 1931 O O   . HOH E 4 .   ? 16.76426 -34.35163 -7.40016  1.000 34.94768 ? 723 HOH B O   1 
HETATM 1932 O O   . HOH E 4 .   ? 36.82620 -32.70090 -4.35413  1.000 48.36805 ? 724 HOH B O   1 
HETATM 1933 O O   . HOH E 4 .   ? 36.51385 -19.86012 9.57595   1.000 52.33818 ? 725 HOH B O   1 
HETATM 1934 O O   . HOH E 4 .   ? 39.66030 -42.16785 -26.46133 1.000 53.35014 ? 726 HOH B O   1 
HETATM 1935 O O   . HOH E 4 .   ? 21.22157 -20.60777 -31.56411 1.000 43.62809 ? 727 HOH B O   1 
HETATM 1936 O O   . HOH E 4 .   ? 23.23719 -10.58231 2.98957   1.000 56.04195 ? 728 HOH B O   1 
HETATM 1937 O O   . HOH E 4 .   ? 21.29414 -19.66723 -28.92990 1.000 48.39991 ? 729 HOH B O   1 
HETATM 1938 O O   . HOH E 4 .   ? 18.63043 -31.02482 -3.97452  1.000 42.32472 ? 730 HOH B O   1 
HETATM 1939 O O   . HOH E 4 .   ? 16.91395 -14.54958 -29.25479 1.000 54.86387 ? 731 HOH B O   1 
HETATM 1940 O O   . HOH E 4 .   ? 37.15577 -32.66371 -20.29791 1.000 35.58299 ? 732 HOH B O   1 
HETATM 1941 O O   . HOH E 4 .   ? 38.24294 -22.69035 -18.02245 1.000 41.84335 ? 733 HOH B O   1 
HETATM 1942 O O   . HOH E 4 .   ? 26.93108 -15.95572 -6.42717  1.000 41.25701 ? 734 HOH B O   1 
HETATM 1943 O O   . HOH E 4 .   ? 28.32619 -14.83977 -8.69641  1.000 47.12480 ? 735 HOH B O   1 
HETATM 1944 O O   . HOH E 4 .   ? 30.29553 -37.13478 -10.56659 1.000 40.68810 ? 736 HOH B O   1 
HETATM 1945 O O   . HOH E 4 .   ? 33.67678 -28.77315 0.41512   1.000 54.10635 ? 737 HOH B O   1 
HETATM 1946 O O   . HOH E 4 .   ? 28.58217 -25.59302 -0.64444  1.000 36.41555 ? 738 HOH B O   1 
HETATM 1947 O O   . HOH E 4 .   ? 16.17400 -33.59633 -18.25795 1.000 48.14933 ? 739 HOH B O   1 
HETATM 1948 O O   . HOH E 4 .   ? 28.49993 -17.38331 -9.12783  1.000 36.40107 ? 740 HOH B O   1 
HETATM 1949 O O   . HOH E 4 .   ? 26.75754 -22.29936 -16.67177 1.000 34.67886 ? 741 HOH B O   1 
HETATM 1950 O O   . HOH E 4 .   ? 18.77842 -33.55786 -15.89582 1.000 39.70019 ? 742 HOH B O   1 
HETATM 1951 O O   . HOH E 4 .   ? 23.24067 -28.82182 -21.18830 1.000 40.29123 ? 743 HOH B O   1 
HETATM 1952 O O   . HOH E 4 .   ? 25.28262 -35.81657 -6.84272  1.000 45.21862 ? 744 HOH B O   1 
HETATM 1953 O O   . HOH E 4 .   ? 35.52578 -17.12719 0.07346   1.000 49.34421 ? 745 HOH B O   1 
HETATM 1954 O O   . HOH E 4 .   ? 48.195   -37.966   -33.349   1.000 44.80401 ? 746 HOH B O   1 
HETATM 1955 O O   . HOH E 4 .   ? 15.17285 -30.31162 -12.96694 1.000 35.09944 ? 747 HOH B O   1 
HETATM 1956 O O   . HOH E 4 .   ? 25.27775 -32.91553 -8.10207  1.000 35.29427 ? 748 HOH B O   1 
HETATM 1957 O O   . HOH E 4 .   ? 35.80926 -20.90265 14.07341  1.000 41.91292 ? 749 HOH B O   1 
HETATM 1958 O O   . HOH E 4 .   ? 43.27703 -26.37178 -19.75047 1.000 49.48894 ? 750 HOH B O   1 
HETATM 1959 O O   . HOH E 4 .   ? 26.42600 -40.73899 -7.13897  1.000 52.22188 ? 751 HOH B O   1 
HETATM 1960 O O   . HOH E 4 .   ? 29.74318 -13.77674 -24.71207 1.000 55.54856 ? 752 HOH B O   1 
HETATM 1961 O O   . HOH E 4 .   ? 41.18712 -36.96627 -23.54960 1.000 51.03934 ? 753 HOH B O   1 
HETATM 1962 O O   . HOH E 4 .   ? 28.18689 -33.58089 6.11648   1.000 55.81808 ? 754 HOH B O   1 
HETATM 1963 O O   . HOH E 4 .   ? 31.63804 -30.30970 -7.65801  1.000 35.48230 ? 755 HOH B O   1 
HETATM 1964 O O   . HOH E 4 .   ? 33.45942 -40.47369 -21.81406 1.000 54.98549 ? 756 HOH B O   1 
HETATM 1965 O O   . HOH E 4 .   ? 29.07718 -38.90950 -21.46926 1.000 41.56332 ? 757 HOH B O   1 
HETATM 1966 O O   . HOH E 4 .   ? 29.74247 -39.10667 1.18433   1.000 58.70207 ? 758 HOH B O   1 
HETATM 1967 O O   . HOH E 4 .   ? 30.16725 -37.06403 -23.08335 1.000 40.29289 ? 759 HOH B O   1 
HETATM 1968 O O   . HOH E 4 .   ? 42.19670 -26.41254 -26.18167 1.000 50.17299 ? 760 HOH B O   1 
HETATM 1969 O O   . HOH E 4 .   ? 28.57131 -10.23480 -10.38289 1.000 53.14197 ? 761 HOH B O   1 
HETATM 1970 O O   . HOH E 4 .   ? 36.20232 -21.19786 -21.01775 1.000 40.42892 ? 762 HOH B O   1 
HETATM 1971 O O   . HOH E 4 .   ? 47.38400 -35.07933 -27.55433 1.000 47.45098 ? 763 HOH B O   1 
HETATM 1972 O O   . HOH E 4 .   ? 38.78622 -32.88845 -22.15569 1.000 42.99958 ? 764 HOH B O   1 
HETATM 1973 O O   . HOH E 4 .   ? 27.42878 -42.02266 -14.50089 1.000 56.74380 ? 765 HOH B O   1 
HETATM 1974 O O   . HOH E 4 .   ? 29.47128 -23.74352 -27.49556 1.000 39.97391 ? 766 HOH B O   1 
HETATM 1975 O O   . HOH E 4 .   ? 36.43054 -24.85139 0.23929   1.000 48.13530 ? 767 HOH B O   1 
HETATM 1976 O O   . HOH E 4 .   ? 41.14362 -27.60704 -13.52714 1.000 45.41827 ? 768 HOH B O   1 
HETATM 1977 O O   . HOH E 4 .   ? 26.66851 -13.76436 -25.44843 1.000 49.46762 ? 769 HOH B O   1 
HETATM 1978 O O   . HOH E 4 .   ? 35.28294 -15.35401 1.86476   1.000 53.43664 ? 770 HOH B O   1 
HETATM 1979 O O   . HOH E 4 .   ? 9.93626  -18.00285 -17.10459 1.000 54.86951 ? 771 HOH B O   1 
HETATM 1980 O O   . HOH E 4 .   ? 19.36007 -13.65008 -8.63261  1.000 45.23547 ? 772 HOH B O   1 
HETATM 1981 O O   . HOH E 4 .   ? 29.93228 -39.23088 -1.77982  1.000 58.33798 ? 773 HOH B O   1 
HETATM 1982 O O   . HOH E 4 .   ? 14.03617 -29.39743 3.04079   1.000 52.33229 ? 774 HOH B O   1 
HETATM 1983 O O   . HOH E 4 .   ? 22.00068 -35.66451 -18.03117 1.000 35.22695 ? 775 HOH B O   1 
HETATM 1984 O O   . HOH E 4 .   ? 7.82307  -23.55741 -21.26691 1.000 46.19166 ? 776 HOH B O   1 
HETATM 1985 O O   . HOH E 4 .   ? 44.42617 -29.65396 -25.81387 1.000 47.07596 ? 777 HOH B O   1 
HETATM 1986 O O   . HOH E 4 .   ? 13.63826 -26.40706 -12.65517 1.000 45.50759 ? 778 HOH B O   1 
HETATM 1987 O O   . HOH E 4 .   ? 37.79186 -36.89726 -11.24602 1.000 49.81163 ? 779 HOH B O   1 
HETATM 1988 O O   . HOH E 4 .   ? 30.62042 -30.81586 9.23310   1.000 52.12224 ? 780 HOH B O   1 
HETATM 1989 O O   . HOH E 4 .   ? 34.07066 -42.35675 -13.71409 1.000 50.72004 ? 781 HOH B O   1 
HETATM 1990 O O   . HOH E 4 .   ? 32.68286 -37.76668 -22.25488 1.000 42.59712 ? 782 HOH B O   1 
HETATM 1991 O O   . HOH E 4 .   ? 35.78114 -31.05717 -33.32190 1.000 40.16581 ? 783 HOH B O   1 
HETATM 1992 O O   . HOH E 4 .   ? 37.80150 -22.96570 10.17357  1.000 42.36336 ? 784 HOH B O   1 
HETATM 1993 O O   . HOH E 4 .   ? 31.99326 -13.85481 5.76919   1.000 53.50401 ? 785 HOH B O   1 
HETATM 1994 O O   . HOH E 4 .   ? 36.77372 -21.51628 -10.61581 1.000 44.74403 ? 786 HOH B O   1 
HETATM 1995 O O   . HOH E 4 .   ? 10.87835 -27.43629 -21.43212 1.000 47.36240 ? 787 HOH B O   1 
HETATM 1996 O O   . HOH E 4 .   ? 38.84000 -29.53852 -6.91010  1.000 49.98314 ? 788 HOH B O   1 
HETATM 1997 O O   . HOH E 4 .   ? 19.94992 -33.96188 -18.16109 1.000 39.25910 ? 789 HOH B O   1 
HETATM 1998 O O   . HOH E 4 .   ? 31.05552 -41.61639 -9.94759  1.000 51.98467 ? 790 HOH B O   1 
HETATM 1999 O O   . HOH E 4 .   ? 21.51975 -41.51378 -15.96258 1.000 55.44317 ? 791 HOH B O   1 
HETATM 2000 O O   . HOH E 4 .   ? 35.32567 -28.18325 19.77144  1.000 46.88687 ? 792 HOH B O   1 
HETATM 2001 O O   . HOH E 4 .   ? 28.05366 -16.53883 15.66225  1.000 53.34153 ? 793 HOH B O   1 
HETATM 2002 O O   . HOH E 4 .   ? 38.67776 -24.15654 7.96872   1.000 48.85875 ? 794 HOH B O   1 
HETATM 2003 O O   . HOH E 4 .   ? 13.20438 -33.64783 -12.70045 1.000 42.25782 ? 795 HOH B O   1 
HETATM 2004 O O   . HOH E 4 .   ? 36.34613 -25.02879 -3.75270  1.000 51.45920 ? 796 HOH B O   1 
HETATM 2005 O O   . HOH E 4 .   ? 15.45288 -34.87001 -15.19243 1.000 50.82279 ? 797 HOH B O   1 
HETATM 2006 O O   . HOH E 4 .   ? 12.67818 -29.11526 -6.55805  1.000 43.48945 ? 798 HOH B O   1 
HETATM 2007 O O   . HOH E 4 .   ? 12.47854 -26.55440 -15.14132 1.000 51.77852 ? 799 HOH B O   1 
HETATM 2008 O O   . HOH E 4 .   ? 10.98249 -15.19707 -16.55378 1.000 57.70252 ? 800 HOH B O   1 
HETATM 2009 O O   . HOH E 4 .   ? 13.25056 -31.82384 -15.46724 1.000 46.85048 ? 801 HOH B O   1 
HETATM 2010 O O   . HOH E 4 .   ? 17.92325 -35.56531 -14.96606 1.000 55.04475 ? 802 HOH B O   1 
HETATM 2011 O O   . HOH E 4 .   ? 16.96194 -35.94897 -5.26624  1.000 47.79464 ? 803 HOH B O   1 
HETATM 2012 O O   . HOH E 4 .   ? 32.445   -22.470   -25.562   1.000 54.39852 ? 804 HOH B O   1 
HETATM 2013 O O   . HOH E 4 .   ? 40.20782 -34.96613 -21.80810 1.000 44.12905 ? 805 HOH B O   1 
HETATM 2014 O O   . HOH E 4 .   ? 18.41627 -35.54960 -19.74756 1.000 50.03983 ? 806 HOH B O   1 
# 
