data_8YDP
# 
_entry.id   8YDP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YDP         pdb_00008ydp 10.2210/pdb8ydp/pdb 
WWPDB D_1300045345 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YDP 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              yoshi.cesp@tmd.ac.jp 
_pdbx_contact_author.name_first         Yoshinori 
_pdbx_contact_author.name_last          Fujiyoshi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8070-1493 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nakamura, S.'  1 0000-0003-2253-6976 
'Numoto, N.'    2 0000-0001-6113-9792 
'Fujiyoshi, Y.' 3 0000-0002-8070-1493 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Development of a short-peptide inhibiting any SARS-CoV-2 variants based on structural biology' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nakamura, S.'  1  0000-0003-2253-6976 
primary 'Tanimura, Y.'  2  ?                   
primary 'Nomura, R.'    3  ?                   
primary 'Suzuki, H.'    4  ?                   
primary 'Nishikawa, K.' 5  ?                   
primary 'Kamegawa, A.'  6  ?                   
primary 'Numoto, N.'    7  ?                   
primary 'Tanaka, A.'    8  ?                   
primary 'Kawabata, S.'  9  ?                   
primary 'Sakaguchi, S.' 10 ?                   
primary 'Emi, A.'       11 ?                   
primary 'Suzuki, Y.'    12 ?                   
primary 'Fujiyoshi, Y.' 13 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 'SARS-CoV-2 inhibiting peptide Ce9'      4825.541  2   ? ? ? ? 
2 polymer     man 'Spike protein S1'                       26198.068 2   ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   2   ? ? ? ? 
4 non-polymer syn GLYCEROL                                 92.094    5   ? ? ? ? 
5 water       nat water                                    18.015    157 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no DKEWILQKIYEIMRRLDEEGHAEASMRVSDLIYEFMKKD DKEWILQKIYEIMRRLDEEGHAEASMRVSDLIYEFMKKD A,C ? 
2 'polypeptide(L)' no no 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGSNSENLYFQGSHHHHHHHHHHGLNDIFEAQKIEWHE
;
B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 GLYCEROL                                 GOL 
5 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   LYS n 
1 3   GLU n 
1 4   TRP n 
1 5   ILE n 
1 6   LEU n 
1 7   GLN n 
1 8   LYS n 
1 9   ILE n 
1 10  TYR n 
1 11  GLU n 
1 12  ILE n 
1 13  MET n 
1 14  ARG n 
1 15  ARG n 
1 16  LEU n 
1 17  ASP n 
1 18  GLU n 
1 19  GLU n 
1 20  GLY n 
1 21  HIS n 
1 22  ALA n 
1 23  GLU n 
1 24  ALA n 
1 25  SER n 
1 26  MET n 
1 27  ARG n 
1 28  VAL n 
1 29  SER n 
1 30  ASP n 
1 31  LEU n 
1 32  ILE n 
1 33  TYR n 
1 34  GLU n 
1 35  PHE n 
1 36  MET n 
1 37  LYS n 
1 38  LYS n 
1 39  ASP n 
2 1   THR n 
2 2   ASN n 
2 3   LEU n 
2 4   CYS n 
2 5   PRO n 
2 6   PHE n 
2 7   GLY n 
2 8   GLU n 
2 9   VAL n 
2 10  PHE n 
2 11  ASN n 
2 12  ALA n 
2 13  THR n 
2 14  ARG n 
2 15  PHE n 
2 16  ALA n 
2 17  SER n 
2 18  VAL n 
2 19  TYR n 
2 20  ALA n 
2 21  TRP n 
2 22  ASN n 
2 23  ARG n 
2 24  LYS n 
2 25  ARG n 
2 26  ILE n 
2 27  SER n 
2 28  ASN n 
2 29  CYS n 
2 30  VAL n 
2 31  ALA n 
2 32  ASP n 
2 33  TYR n 
2 34  SER n 
2 35  VAL n 
2 36  LEU n 
2 37  TYR n 
2 38  ASN n 
2 39  SER n 
2 40  ALA n 
2 41  SER n 
2 42  PHE n 
2 43  SER n 
2 44  THR n 
2 45  PHE n 
2 46  LYS n 
2 47  CYS n 
2 48  TYR n 
2 49  GLY n 
2 50  VAL n 
2 51  SER n 
2 52  PRO n 
2 53  THR n 
2 54  LYS n 
2 55  LEU n 
2 56  ASN n 
2 57  ASP n 
2 58  LEU n 
2 59  CYS n 
2 60  PHE n 
2 61  THR n 
2 62  ASN n 
2 63  VAL n 
2 64  TYR n 
2 65  ALA n 
2 66  ASP n 
2 67  SER n 
2 68  PHE n 
2 69  VAL n 
2 70  ILE n 
2 71  ARG n 
2 72  GLY n 
2 73  ASP n 
2 74  GLU n 
2 75  VAL n 
2 76  ARG n 
2 77  GLN n 
2 78  ILE n 
2 79  ALA n 
2 80  PRO n 
2 81  GLY n 
2 82  GLN n 
2 83  THR n 
2 84  GLY n 
2 85  LYS n 
2 86  ILE n 
2 87  ALA n 
2 88  ASP n 
2 89  TYR n 
2 90  ASN n 
2 91  TYR n 
2 92  LYS n 
2 93  LEU n 
2 94  PRO n 
2 95  ASP n 
2 96  ASP n 
2 97  PHE n 
2 98  THR n 
2 99  GLY n 
2 100 CYS n 
2 101 VAL n 
2 102 ILE n 
2 103 ALA n 
2 104 TRP n 
2 105 ASN n 
2 106 SER n 
2 107 ASN n 
2 108 ASN n 
2 109 LEU n 
2 110 ASP n 
2 111 SER n 
2 112 LYS n 
2 113 VAL n 
2 114 GLY n 
2 115 GLY n 
2 116 ASN n 
2 117 TYR n 
2 118 ASN n 
2 119 TYR n 
2 120 LEU n 
2 121 TYR n 
2 122 ARG n 
2 123 LEU n 
2 124 PHE n 
2 125 ARG n 
2 126 LYS n 
2 127 SER n 
2 128 ASN n 
2 129 LEU n 
2 130 LYS n 
2 131 PRO n 
2 132 PHE n 
2 133 GLU n 
2 134 ARG n 
2 135 ASP n 
2 136 ILE n 
2 137 SER n 
2 138 THR n 
2 139 GLU n 
2 140 ILE n 
2 141 TYR n 
2 142 GLN n 
2 143 ALA n 
2 144 GLY n 
2 145 SER n 
2 146 THR n 
2 147 PRO n 
2 148 CYS n 
2 149 ASN n 
2 150 GLY n 
2 151 VAL n 
2 152 GLU n 
2 153 GLY n 
2 154 PHE n 
2 155 ASN n 
2 156 CYS n 
2 157 TYR n 
2 158 PHE n 
2 159 PRO n 
2 160 LEU n 
2 161 GLN n 
2 162 SER n 
2 163 TYR n 
2 164 GLY n 
2 165 PHE n 
2 166 GLN n 
2 167 PRO n 
2 168 THR n 
2 169 ASN n 
2 170 GLY n 
2 171 VAL n 
2 172 GLY n 
2 173 TYR n 
2 174 GLN n 
2 175 PRO n 
2 176 TYR n 
2 177 ARG n 
2 178 VAL n 
2 179 VAL n 
2 180 VAL n 
2 181 LEU n 
2 182 SER n 
2 183 PHE n 
2 184 GLU n 
2 185 LEU n 
2 186 LEU n 
2 187 HIS n 
2 188 ALA n 
2 189 PRO n 
2 190 ALA n 
2 191 THR n 
2 192 VAL n 
2 193 CYS n 
2 194 GLY n 
2 195 SER n 
2 196 ASN n 
2 197 SER n 
2 198 GLU n 
2 199 ASN n 
2 200 LEU n 
2 201 TYR n 
2 202 PHE n 
2 203 GLN n 
2 204 GLY n 
2 205 SER n 
2 206 HIS n 
2 207 HIS n 
2 208 HIS n 
2 209 HIS n 
2 210 HIS n 
2 211 HIS n 
2 212 HIS n 
2 213 HIS n 
2 214 HIS n 
2 215 HIS n 
2 216 GLY n 
2 217 LEU n 
2 218 ASN n 
2 219 ASP n 
2 220 ILE n 
2 221 PHE n 
2 222 GLU n 
2 223 ALA n 
2 224 GLN n 
2 225 LYS n 
2 226 ILE n 
2 227 GLU n 
2 228 TRP n 
2 229 HIS n 
2 230 GLU n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   230 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'S, 2' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            Expi293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       39 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
GOL non-polymer                  . GLYCEROL                                 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       
92.094  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   1   1   ASP ASP A . n 
A 1 2   LYS 2   2   2   LYS LYS A . n 
A 1 3   GLU 3   3   3   GLU GLU A . n 
A 1 4   TRP 4   4   4   TRP TRP A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   LYS 8   8   8   LYS LYS A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  TYR 10  10  10  TYR TYR A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  MET 13  13  13  MET MET A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  ASP 17  17  17  ASP ASP A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  HIS 21  21  21  HIS HIS A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  MET 26  26  26  MET MET A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  SER 29  29  29  SER SER A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  TYR 33  33  33  TYR TYR A . n 
A 1 34  GLU 34  34  34  GLU GLU A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
B 2 1   THR 1   333 ?   ?   ?   B . n 
B 2 2   ASN 2   334 334 ASN ASN B . n 
B 2 3   LEU 3   335 335 LEU LEU B . n 
B 2 4   CYS 4   336 336 CYS CYS B . n 
B 2 5   PRO 5   337 337 PRO PRO B . n 
B 2 6   PHE 6   338 338 PHE PHE B . n 
B 2 7   GLY 7   339 339 GLY GLY B . n 
B 2 8   GLU 8   340 340 GLU GLU B . n 
B 2 9   VAL 9   341 341 VAL VAL B . n 
B 2 10  PHE 10  342 342 PHE PHE B . n 
B 2 11  ASN 11  343 343 ASN ASN B . n 
B 2 12  ALA 12  344 344 ALA ALA B . n 
B 2 13  THR 13  345 345 THR THR B . n 
B 2 14  ARG 14  346 346 ARG ARG B . n 
B 2 15  PHE 15  347 347 PHE PHE B . n 
B 2 16  ALA 16  348 348 ALA ALA B . n 
B 2 17  SER 17  349 349 SER SER B . n 
B 2 18  VAL 18  350 350 VAL VAL B . n 
B 2 19  TYR 19  351 351 TYR TYR B . n 
B 2 20  ALA 20  352 352 ALA ALA B . n 
B 2 21  TRP 21  353 353 TRP TRP B . n 
B 2 22  ASN 22  354 354 ASN ASN B . n 
B 2 23  ARG 23  355 355 ARG ARG B . n 
B 2 24  LYS 24  356 356 LYS LYS B . n 
B 2 25  ARG 25  357 357 ARG ARG B . n 
B 2 26  ILE 26  358 358 ILE ILE B . n 
B 2 27  SER 27  359 359 SER SER B . n 
B 2 28  ASN 28  360 360 ASN ASN B . n 
B 2 29  CYS 29  361 361 CYS CYS B . n 
B 2 30  VAL 30  362 362 VAL VAL B . n 
B 2 31  ALA 31  363 363 ALA ALA B . n 
B 2 32  ASP 32  364 364 ASP ASP B . n 
B 2 33  TYR 33  365 365 TYR TYR B . n 
B 2 34  SER 34  366 366 SER SER B . n 
B 2 35  VAL 35  367 367 VAL VAL B . n 
B 2 36  LEU 36  368 368 LEU LEU B . n 
B 2 37  TYR 37  369 369 TYR TYR B . n 
B 2 38  ASN 38  370 370 ASN ASN B . n 
B 2 39  SER 39  371 371 SER SER B . n 
B 2 40  ALA 40  372 372 ALA ALA B . n 
B 2 41  SER 41  373 373 SER SER B . n 
B 2 42  PHE 42  374 374 PHE PHE B . n 
B 2 43  SER 43  375 375 SER SER B . n 
B 2 44  THR 44  376 376 THR THR B . n 
B 2 45  PHE 45  377 377 PHE PHE B . n 
B 2 46  LYS 46  378 378 LYS LYS B . n 
B 2 47  CYS 47  379 379 CYS CYS B . n 
B 2 48  TYR 48  380 380 TYR TYR B . n 
B 2 49  GLY 49  381 381 GLY GLY B . n 
B 2 50  VAL 50  382 382 VAL VAL B . n 
B 2 51  SER 51  383 383 SER SER B . n 
B 2 52  PRO 52  384 384 PRO PRO B . n 
B 2 53  THR 53  385 385 THR THR B . n 
B 2 54  LYS 54  386 386 LYS LYS B . n 
B 2 55  LEU 55  387 387 LEU LEU B . n 
B 2 56  ASN 56  388 388 ASN ASN B . n 
B 2 57  ASP 57  389 389 ASP ASP B . n 
B 2 58  LEU 58  390 390 LEU LEU B . n 
B 2 59  CYS 59  391 391 CYS CYS B . n 
B 2 60  PHE 60  392 392 PHE PHE B . n 
B 2 61  THR 61  393 393 THR THR B . n 
B 2 62  ASN 62  394 394 ASN ASN B . n 
B 2 63  VAL 63  395 395 VAL VAL B . n 
B 2 64  TYR 64  396 396 TYR TYR B . n 
B 2 65  ALA 65  397 397 ALA ALA B . n 
B 2 66  ASP 66  398 398 ASP ASP B . n 
B 2 67  SER 67  399 399 SER SER B . n 
B 2 68  PHE 68  400 400 PHE PHE B . n 
B 2 69  VAL 69  401 401 VAL VAL B . n 
B 2 70  ILE 70  402 402 ILE ILE B . n 
B 2 71  ARG 71  403 403 ARG ARG B . n 
B 2 72  GLY 72  404 404 GLY GLY B . n 
B 2 73  ASP 73  405 405 ASP ASP B . n 
B 2 74  GLU 74  406 406 GLU GLU B . n 
B 2 75  VAL 75  407 407 VAL VAL B . n 
B 2 76  ARG 76  408 408 ARG ARG B . n 
B 2 77  GLN 77  409 409 GLN GLN B . n 
B 2 78  ILE 78  410 410 ILE ILE B . n 
B 2 79  ALA 79  411 411 ALA ALA B . n 
B 2 80  PRO 80  412 412 PRO PRO B . n 
B 2 81  GLY 81  413 413 GLY GLY B . n 
B 2 82  GLN 82  414 414 GLN GLN B . n 
B 2 83  THR 83  415 415 THR THR B . n 
B 2 84  GLY 84  416 416 GLY GLY B . n 
B 2 85  LYS 85  417 417 LYS LYS B . n 
B 2 86  ILE 86  418 418 ILE ILE B . n 
B 2 87  ALA 87  419 419 ALA ALA B . n 
B 2 88  ASP 88  420 420 ASP ASP B . n 
B 2 89  TYR 89  421 421 TYR TYR B . n 
B 2 90  ASN 90  422 422 ASN ASN B . n 
B 2 91  TYR 91  423 423 TYR TYR B . n 
B 2 92  LYS 92  424 424 LYS LYS B . n 
B 2 93  LEU 93  425 425 LEU LEU B . n 
B 2 94  PRO 94  426 426 PRO PRO B . n 
B 2 95  ASP 95  427 427 ASP ASP B . n 
B 2 96  ASP 96  428 428 ASP ASP B . n 
B 2 97  PHE 97  429 429 PHE PHE B . n 
B 2 98  THR 98  430 430 THR THR B . n 
B 2 99  GLY 99  431 431 GLY GLY B . n 
B 2 100 CYS 100 432 432 CYS CYS B . n 
B 2 101 VAL 101 433 433 VAL VAL B . n 
B 2 102 ILE 102 434 434 ILE ILE B . n 
B 2 103 ALA 103 435 435 ALA ALA B . n 
B 2 104 TRP 104 436 436 TRP TRP B . n 
B 2 105 ASN 105 437 437 ASN ASN B . n 
B 2 106 SER 106 438 438 SER SER B . n 
B 2 107 ASN 107 439 439 ASN ASN B . n 
B 2 108 ASN 108 440 440 ASN ASN B . n 
B 2 109 LEU 109 441 441 LEU LEU B . n 
B 2 110 ASP 110 442 442 ASP ASP B . n 
B 2 111 SER 111 443 443 SER SER B . n 
B 2 112 LYS 112 444 444 LYS LYS B . n 
B 2 113 VAL 113 445 445 VAL VAL B . n 
B 2 114 GLY 114 446 446 GLY GLY B . n 
B 2 115 GLY 115 447 447 GLY GLY B . n 
B 2 116 ASN 116 448 448 ASN ASN B . n 
B 2 117 TYR 117 449 449 TYR TYR B . n 
B 2 118 ASN 118 450 450 ASN ASN B . n 
B 2 119 TYR 119 451 451 TYR TYR B . n 
B 2 120 LEU 120 452 452 LEU LEU B . n 
B 2 121 TYR 121 453 453 TYR TYR B . n 
B 2 122 ARG 122 454 454 ARG ARG B . n 
B 2 123 LEU 123 455 455 LEU LEU B . n 
B 2 124 PHE 124 456 456 PHE PHE B . n 
B 2 125 ARG 125 457 457 ARG ARG B . n 
B 2 126 LYS 126 458 458 LYS LYS B . n 
B 2 127 SER 127 459 459 SER SER B . n 
B 2 128 ASN 128 460 460 ASN ASN B . n 
B 2 129 LEU 129 461 461 LEU LEU B . n 
B 2 130 LYS 130 462 462 LYS LYS B . n 
B 2 131 PRO 131 463 463 PRO PRO B . n 
B 2 132 PHE 132 464 464 PHE PHE B . n 
B 2 133 GLU 133 465 465 GLU GLU B . n 
B 2 134 ARG 134 466 466 ARG ARG B . n 
B 2 135 ASP 135 467 467 ASP ASP B . n 
B 2 136 ILE 136 468 468 ILE ILE B . n 
B 2 137 SER 137 469 469 SER SER B . n 
B 2 138 THR 138 470 470 THR THR B . n 
B 2 139 GLU 139 471 471 GLU GLU B . n 
B 2 140 ILE 140 472 472 ILE ILE B . n 
B 2 141 TYR 141 473 473 TYR TYR B . n 
B 2 142 GLN 142 474 474 GLN GLN B . n 
B 2 143 ALA 143 475 475 ALA ALA B . n 
B 2 144 GLY 144 476 476 GLY GLY B . n 
B 2 145 SER 145 477 477 SER SER B . n 
B 2 146 THR 146 478 478 THR THR B . n 
B 2 147 PRO 147 479 479 PRO PRO B . n 
B 2 148 CYS 148 480 480 CYS CYS B . n 
B 2 149 ASN 149 481 481 ASN ASN B . n 
B 2 150 GLY 150 482 482 GLY GLY B . n 
B 2 151 VAL 151 483 483 VAL VAL B . n 
B 2 152 GLU 152 484 484 GLU GLU B . n 
B 2 153 GLY 153 485 485 GLY GLY B . n 
B 2 154 PHE 154 486 486 PHE PHE B . n 
B 2 155 ASN 155 487 487 ASN ASN B . n 
B 2 156 CYS 156 488 488 CYS CYS B . n 
B 2 157 TYR 157 489 489 TYR TYR B . n 
B 2 158 PHE 158 490 490 PHE PHE B . n 
B 2 159 PRO 159 491 491 PRO PRO B . n 
B 2 160 LEU 160 492 492 LEU LEU B . n 
B 2 161 GLN 161 493 493 GLN GLN B . n 
B 2 162 SER 162 494 494 SER SER B . n 
B 2 163 TYR 163 495 495 TYR TYR B . n 
B 2 164 GLY 164 496 496 GLY GLY B . n 
B 2 165 PHE 165 497 497 PHE PHE B . n 
B 2 166 GLN 166 498 498 GLN GLN B . n 
B 2 167 PRO 167 499 499 PRO PRO B . n 
B 2 168 THR 168 500 500 THR THR B . n 
B 2 169 ASN 169 501 501 ASN ASN B . n 
B 2 170 GLY 170 502 502 GLY GLY B . n 
B 2 171 VAL 171 503 503 VAL VAL B . n 
B 2 172 GLY 172 504 504 GLY GLY B . n 
B 2 173 TYR 173 505 505 TYR TYR B . n 
B 2 174 GLN 174 506 506 GLN GLN B . n 
B 2 175 PRO 175 507 507 PRO PRO B . n 
B 2 176 TYR 176 508 508 TYR TYR B . n 
B 2 177 ARG 177 509 509 ARG ARG B . n 
B 2 178 VAL 178 510 510 VAL VAL B . n 
B 2 179 VAL 179 511 511 VAL VAL B . n 
B 2 180 VAL 180 512 512 VAL VAL B . n 
B 2 181 LEU 181 513 513 LEU LEU B . n 
B 2 182 SER 182 514 514 SER SER B . n 
B 2 183 PHE 183 515 515 PHE PHE B . n 
B 2 184 GLU 184 516 516 GLU GLU B . n 
B 2 185 LEU 185 517 517 LEU LEU B . n 
B 2 186 LEU 186 518 518 LEU LEU B . n 
B 2 187 HIS 187 519 519 HIS HIS B . n 
B 2 188 ALA 188 520 520 ALA ALA B . n 
B 2 189 PRO 189 521 521 PRO PRO B . n 
B 2 190 ALA 190 522 522 ALA ALA B . n 
B 2 191 THR 191 523 523 THR THR B . n 
B 2 192 VAL 192 524 524 VAL VAL B . n 
B 2 193 CYS 193 525 525 CYS CYS B . n 
B 2 194 GLY 194 526 526 GLY GLY B . n 
B 2 195 SER 195 527 527 SER SER B . n 
B 2 196 ASN 196 528 528 ASN ASN B . n 
B 2 197 SER 197 529 529 SER SER B . n 
B 2 198 GLU 198 530 530 GLU GLU B . n 
B 2 199 ASN 199 531 531 ASN ASN B . n 
B 2 200 LEU 200 532 532 LEU LEU B . n 
B 2 201 TYR 201 533 ?   ?   ?   B . n 
B 2 202 PHE 202 534 ?   ?   ?   B . n 
B 2 203 GLN 203 535 ?   ?   ?   B . n 
B 2 204 GLY 204 536 ?   ?   ?   B . n 
B 2 205 SER 205 537 ?   ?   ?   B . n 
B 2 206 HIS 206 538 ?   ?   ?   B . n 
B 2 207 HIS 207 539 ?   ?   ?   B . n 
B 2 208 HIS 208 540 ?   ?   ?   B . n 
B 2 209 HIS 209 541 ?   ?   ?   B . n 
B 2 210 HIS 210 542 ?   ?   ?   B . n 
B 2 211 HIS 211 543 ?   ?   ?   B . n 
B 2 212 HIS 212 544 ?   ?   ?   B . n 
B 2 213 HIS 213 545 ?   ?   ?   B . n 
B 2 214 HIS 214 546 ?   ?   ?   B . n 
B 2 215 HIS 215 547 ?   ?   ?   B . n 
B 2 216 GLY 216 548 ?   ?   ?   B . n 
B 2 217 LEU 217 549 ?   ?   ?   B . n 
B 2 218 ASN 218 550 ?   ?   ?   B . n 
B 2 219 ASP 219 551 ?   ?   ?   B . n 
B 2 220 ILE 220 552 ?   ?   ?   B . n 
B 2 221 PHE 221 553 ?   ?   ?   B . n 
B 2 222 GLU 222 554 ?   ?   ?   B . n 
B 2 223 ALA 223 555 ?   ?   ?   B . n 
B 2 224 GLN 224 556 ?   ?   ?   B . n 
B 2 225 LYS 225 557 ?   ?   ?   B . n 
B 2 226 ILE 226 558 ?   ?   ?   B . n 
B 2 227 GLU 227 559 ?   ?   ?   B . n 
B 2 228 TRP 228 560 ?   ?   ?   B . n 
B 2 229 HIS 229 561 ?   ?   ?   B . n 
B 2 230 GLU 230 562 ?   ?   ?   B . n 
C 1 1   ASP 1   1   1   ASP ASP C . n 
C 1 2   LYS 2   2   2   LYS LYS C . n 
C 1 3   GLU 3   3   3   GLU GLU C . n 
C 1 4   TRP 4   4   4   TRP TRP C . n 
C 1 5   ILE 5   5   5   ILE ILE C . n 
C 1 6   LEU 6   6   6   LEU LEU C . n 
C 1 7   GLN 7   7   7   GLN GLN C . n 
C 1 8   LYS 8   8   8   LYS LYS C . n 
C 1 9   ILE 9   9   9   ILE ILE C . n 
C 1 10  TYR 10  10  10  TYR TYR C . n 
C 1 11  GLU 11  11  11  GLU GLU C . n 
C 1 12  ILE 12  12  12  ILE ILE C . n 
C 1 13  MET 13  13  13  MET MET C . n 
C 1 14  ARG 14  14  14  ARG ARG C . n 
C 1 15  ARG 15  15  15  ARG ARG C . n 
C 1 16  LEU 16  16  16  LEU LEU C . n 
C 1 17  ASP 17  17  17  ASP ASP C . n 
C 1 18  GLU 18  18  18  GLU GLU C . n 
C 1 19  GLU 19  19  19  GLU GLU C . n 
C 1 20  GLY 20  20  20  GLY GLY C . n 
C 1 21  HIS 21  21  21  HIS HIS C . n 
C 1 22  ALA 22  22  22  ALA ALA C . n 
C 1 23  GLU 23  23  23  GLU GLU C . n 
C 1 24  ALA 24  24  24  ALA ALA C . n 
C 1 25  SER 25  25  25  SER SER C . n 
C 1 26  MET 26  26  26  MET MET C . n 
C 1 27  ARG 27  27  27  ARG ARG C . n 
C 1 28  VAL 28  28  28  VAL VAL C . n 
C 1 29  SER 29  29  29  SER SER C . n 
C 1 30  ASP 30  30  30  ASP ASP C . n 
C 1 31  LEU 31  31  31  LEU LEU C . n 
C 1 32  ILE 32  32  32  ILE ILE C . n 
C 1 33  TYR 33  33  33  TYR TYR C . n 
C 1 34  GLU 34  34  34  GLU GLU C . n 
C 1 35  PHE 35  35  35  PHE PHE C . n 
C 1 36  MET 36  36  36  MET MET C . n 
C 1 37  LYS 37  37  37  LYS LYS C . n 
C 1 38  LYS 38  38  38  LYS LYS C . n 
C 1 39  ASP 39  39  39  ASP ASP C . n 
D 2 1   THR 1   333 ?   ?   ?   D . n 
D 2 2   ASN 2   334 334 ASN ASN D . n 
D 2 3   LEU 3   335 335 LEU LEU D . n 
D 2 4   CYS 4   336 336 CYS CYS D . n 
D 2 5   PRO 5   337 337 PRO PRO D . n 
D 2 6   PHE 6   338 338 PHE PHE D . n 
D 2 7   GLY 7   339 339 GLY GLY D . n 
D 2 8   GLU 8   340 340 GLU GLU D . n 
D 2 9   VAL 9   341 341 VAL VAL D . n 
D 2 10  PHE 10  342 342 PHE PHE D . n 
D 2 11  ASN 11  343 343 ASN ASN D . n 
D 2 12  ALA 12  344 344 ALA ALA D . n 
D 2 13  THR 13  345 345 THR THR D . n 
D 2 14  ARG 14  346 346 ARG ARG D . n 
D 2 15  PHE 15  347 347 PHE PHE D . n 
D 2 16  ALA 16  348 348 ALA ALA D . n 
D 2 17  SER 17  349 349 SER SER D . n 
D 2 18  VAL 18  350 350 VAL VAL D . n 
D 2 19  TYR 19  351 351 TYR TYR D . n 
D 2 20  ALA 20  352 352 ALA ALA D . n 
D 2 21  TRP 21  353 353 TRP TRP D . n 
D 2 22  ASN 22  354 354 ASN ASN D . n 
D 2 23  ARG 23  355 355 ARG ARG D . n 
D 2 24  LYS 24  356 356 LYS LYS D . n 
D 2 25  ARG 25  357 357 ARG ARG D . n 
D 2 26  ILE 26  358 358 ILE ILE D . n 
D 2 27  SER 27  359 359 SER SER D . n 
D 2 28  ASN 28  360 360 ASN ASN D . n 
D 2 29  CYS 29  361 361 CYS CYS D . n 
D 2 30  VAL 30  362 362 VAL VAL D . n 
D 2 31  ALA 31  363 363 ALA ALA D . n 
D 2 32  ASP 32  364 364 ASP ASP D . n 
D 2 33  TYR 33  365 365 TYR TYR D . n 
D 2 34  SER 34  366 366 SER SER D . n 
D 2 35  VAL 35  367 367 VAL VAL D . n 
D 2 36  LEU 36  368 368 LEU LEU D . n 
D 2 37  TYR 37  369 369 TYR TYR D . n 
D 2 38  ASN 38  370 370 ASN ASN D . n 
D 2 39  SER 39  371 371 SER SER D . n 
D 2 40  ALA 40  372 372 ALA ALA D . n 
D 2 41  SER 41  373 373 SER SER D . n 
D 2 42  PHE 42  374 374 PHE PHE D . n 
D 2 43  SER 43  375 375 SER SER D . n 
D 2 44  THR 44  376 376 THR THR D . n 
D 2 45  PHE 45  377 377 PHE PHE D . n 
D 2 46  LYS 46  378 378 LYS LYS D . n 
D 2 47  CYS 47  379 379 CYS CYS D . n 
D 2 48  TYR 48  380 380 TYR TYR D . n 
D 2 49  GLY 49  381 381 GLY GLY D . n 
D 2 50  VAL 50  382 382 VAL VAL D . n 
D 2 51  SER 51  383 383 SER SER D . n 
D 2 52  PRO 52  384 384 PRO PRO D . n 
D 2 53  THR 53  385 385 THR THR D . n 
D 2 54  LYS 54  386 386 LYS LYS D . n 
D 2 55  LEU 55  387 387 LEU LEU D . n 
D 2 56  ASN 56  388 388 ASN ASN D . n 
D 2 57  ASP 57  389 389 ASP ASP D . n 
D 2 58  LEU 58  390 390 LEU LEU D . n 
D 2 59  CYS 59  391 391 CYS CYS D . n 
D 2 60  PHE 60  392 392 PHE PHE D . n 
D 2 61  THR 61  393 393 THR THR D . n 
D 2 62  ASN 62  394 394 ASN ASN D . n 
D 2 63  VAL 63  395 395 VAL VAL D . n 
D 2 64  TYR 64  396 396 TYR TYR D . n 
D 2 65  ALA 65  397 397 ALA ALA D . n 
D 2 66  ASP 66  398 398 ASP ASP D . n 
D 2 67  SER 67  399 399 SER SER D . n 
D 2 68  PHE 68  400 400 PHE PHE D . n 
D 2 69  VAL 69  401 401 VAL VAL D . n 
D 2 70  ILE 70  402 402 ILE ILE D . n 
D 2 71  ARG 71  403 403 ARG ARG D . n 
D 2 72  GLY 72  404 404 GLY GLY D . n 
D 2 73  ASP 73  405 405 ASP ASP D . n 
D 2 74  GLU 74  406 406 GLU GLU D . n 
D 2 75  VAL 75  407 407 VAL VAL D . n 
D 2 76  ARG 76  408 408 ARG ARG D . n 
D 2 77  GLN 77  409 409 GLN GLN D . n 
D 2 78  ILE 78  410 410 ILE ILE D . n 
D 2 79  ALA 79  411 411 ALA ALA D . n 
D 2 80  PRO 80  412 412 PRO PRO D . n 
D 2 81  GLY 81  413 413 GLY GLY D . n 
D 2 82  GLN 82  414 414 GLN GLN D . n 
D 2 83  THR 83  415 415 THR THR D . n 
D 2 84  GLY 84  416 416 GLY GLY D . n 
D 2 85  LYS 85  417 417 LYS LYS D . n 
D 2 86  ILE 86  418 418 ILE ILE D . n 
D 2 87  ALA 87  419 419 ALA ALA D . n 
D 2 88  ASP 88  420 420 ASP ASP D . n 
D 2 89  TYR 89  421 421 TYR TYR D . n 
D 2 90  ASN 90  422 422 ASN ASN D . n 
D 2 91  TYR 91  423 423 TYR TYR D . n 
D 2 92  LYS 92  424 424 LYS LYS D . n 
D 2 93  LEU 93  425 425 LEU LEU D . n 
D 2 94  PRO 94  426 426 PRO PRO D . n 
D 2 95  ASP 95  427 427 ASP ASP D . n 
D 2 96  ASP 96  428 428 ASP ASP D . n 
D 2 97  PHE 97  429 429 PHE PHE D . n 
D 2 98  THR 98  430 430 THR THR D . n 
D 2 99  GLY 99  431 431 GLY GLY D . n 
D 2 100 CYS 100 432 432 CYS CYS D . n 
D 2 101 VAL 101 433 433 VAL VAL D . n 
D 2 102 ILE 102 434 434 ILE ILE D . n 
D 2 103 ALA 103 435 435 ALA ALA D . n 
D 2 104 TRP 104 436 436 TRP TRP D . n 
D 2 105 ASN 105 437 437 ASN ASN D . n 
D 2 106 SER 106 438 438 SER SER D . n 
D 2 107 ASN 107 439 439 ASN ASN D . n 
D 2 108 ASN 108 440 440 ASN ASN D . n 
D 2 109 LEU 109 441 441 LEU LEU D . n 
D 2 110 ASP 110 442 442 ASP ASP D . n 
D 2 111 SER 111 443 443 SER SER D . n 
D 2 112 LYS 112 444 444 LYS LYS D . n 
D 2 113 VAL 113 445 445 VAL VAL D . n 
D 2 114 GLY 114 446 446 GLY GLY D . n 
D 2 115 GLY 115 447 447 GLY GLY D . n 
D 2 116 ASN 116 448 448 ASN ASN D . n 
D 2 117 TYR 117 449 449 TYR TYR D . n 
D 2 118 ASN 118 450 450 ASN ASN D . n 
D 2 119 TYR 119 451 451 TYR TYR D . n 
D 2 120 LEU 120 452 452 LEU LEU D . n 
D 2 121 TYR 121 453 453 TYR TYR D . n 
D 2 122 ARG 122 454 454 ARG ARG D . n 
D 2 123 LEU 123 455 455 LEU LEU D . n 
D 2 124 PHE 124 456 456 PHE PHE D . n 
D 2 125 ARG 125 457 457 ARG ARG D . n 
D 2 126 LYS 126 458 458 LYS LYS D . n 
D 2 127 SER 127 459 459 SER SER D . n 
D 2 128 ASN 128 460 460 ASN ASN D . n 
D 2 129 LEU 129 461 461 LEU LEU D . n 
D 2 130 LYS 130 462 462 LYS LYS D . n 
D 2 131 PRO 131 463 463 PRO PRO D . n 
D 2 132 PHE 132 464 464 PHE PHE D . n 
D 2 133 GLU 133 465 465 GLU GLU D . n 
D 2 134 ARG 134 466 466 ARG ARG D . n 
D 2 135 ASP 135 467 467 ASP ASP D . n 
D 2 136 ILE 136 468 468 ILE ILE D . n 
D 2 137 SER 137 469 469 SER SER D . n 
D 2 138 THR 138 470 470 THR THR D . n 
D 2 139 GLU 139 471 471 GLU GLU D . n 
D 2 140 ILE 140 472 472 ILE ILE D . n 
D 2 141 TYR 141 473 473 TYR TYR D . n 
D 2 142 GLN 142 474 474 GLN GLN D . n 
D 2 143 ALA 143 475 475 ALA ALA D . n 
D 2 144 GLY 144 476 476 GLY GLY D . n 
D 2 145 SER 145 477 477 SER SER D . n 
D 2 146 THR 146 478 478 THR THR D . n 
D 2 147 PRO 147 479 479 PRO PRO D . n 
D 2 148 CYS 148 480 480 CYS CYS D . n 
D 2 149 ASN 149 481 481 ASN ASN D . n 
D 2 150 GLY 150 482 482 GLY GLY D . n 
D 2 151 VAL 151 483 483 VAL VAL D . n 
D 2 152 GLU 152 484 484 GLU GLU D . n 
D 2 153 GLY 153 485 485 GLY GLY D . n 
D 2 154 PHE 154 486 486 PHE PHE D . n 
D 2 155 ASN 155 487 487 ASN ASN D . n 
D 2 156 CYS 156 488 488 CYS CYS D . n 
D 2 157 TYR 157 489 489 TYR TYR D . n 
D 2 158 PHE 158 490 490 PHE PHE D . n 
D 2 159 PRO 159 491 491 PRO PRO D . n 
D 2 160 LEU 160 492 492 LEU LEU D . n 
D 2 161 GLN 161 493 493 GLN GLN D . n 
D 2 162 SER 162 494 494 SER SER D . n 
D 2 163 TYR 163 495 495 TYR TYR D . n 
D 2 164 GLY 164 496 496 GLY GLY D . n 
D 2 165 PHE 165 497 497 PHE PHE D . n 
D 2 166 GLN 166 498 498 GLN GLN D . n 
D 2 167 PRO 167 499 499 PRO PRO D . n 
D 2 168 THR 168 500 500 THR THR D . n 
D 2 169 ASN 169 501 501 ASN ASN D . n 
D 2 170 GLY 170 502 502 GLY GLY D . n 
D 2 171 VAL 171 503 503 VAL VAL D . n 
D 2 172 GLY 172 504 504 GLY GLY D . n 
D 2 173 TYR 173 505 505 TYR TYR D . n 
D 2 174 GLN 174 506 506 GLN GLN D . n 
D 2 175 PRO 175 507 507 PRO PRO D . n 
D 2 176 TYR 176 508 508 TYR TYR D . n 
D 2 177 ARG 177 509 509 ARG ARG D . n 
D 2 178 VAL 178 510 510 VAL VAL D . n 
D 2 179 VAL 179 511 511 VAL VAL D . n 
D 2 180 VAL 180 512 512 VAL VAL D . n 
D 2 181 LEU 181 513 513 LEU LEU D . n 
D 2 182 SER 182 514 514 SER SER D . n 
D 2 183 PHE 183 515 515 PHE PHE D . n 
D 2 184 GLU 184 516 516 GLU GLU D . n 
D 2 185 LEU 185 517 517 LEU LEU D . n 
D 2 186 LEU 186 518 518 LEU LEU D . n 
D 2 187 HIS 187 519 519 HIS HIS D . n 
D 2 188 ALA 188 520 520 ALA ALA D . n 
D 2 189 PRO 189 521 521 PRO PRO D . n 
D 2 190 ALA 190 522 522 ALA ALA D . n 
D 2 191 THR 191 523 523 THR THR D . n 
D 2 192 VAL 192 524 524 VAL VAL D . n 
D 2 193 CYS 193 525 525 CYS CYS D . n 
D 2 194 GLY 194 526 526 GLY GLY D . n 
D 2 195 SER 195 527 527 SER SER D . n 
D 2 196 ASN 196 528 528 ASN ASN D . n 
D 2 197 SER 197 529 529 SER SER D . n 
D 2 198 GLU 198 530 530 GLU GLU D . n 
D 2 199 ASN 199 531 ?   ?   ?   D . n 
D 2 200 LEU 200 532 ?   ?   ?   D . n 
D 2 201 TYR 201 533 ?   ?   ?   D . n 
D 2 202 PHE 202 534 ?   ?   ?   D . n 
D 2 203 GLN 203 535 ?   ?   ?   D . n 
D 2 204 GLY 204 536 ?   ?   ?   D . n 
D 2 205 SER 205 537 ?   ?   ?   D . n 
D 2 206 HIS 206 538 ?   ?   ?   D . n 
D 2 207 HIS 207 539 ?   ?   ?   D . n 
D 2 208 HIS 208 540 ?   ?   ?   D . n 
D 2 209 HIS 209 541 ?   ?   ?   D . n 
D 2 210 HIS 210 542 ?   ?   ?   D . n 
D 2 211 HIS 211 543 ?   ?   ?   D . n 
D 2 212 HIS 212 544 ?   ?   ?   D . n 
D 2 213 HIS 213 545 ?   ?   ?   D . n 
D 2 214 HIS 214 546 ?   ?   ?   D . n 
D 2 215 HIS 215 547 ?   ?   ?   D . n 
D 2 216 GLY 216 548 ?   ?   ?   D . n 
D 2 217 LEU 217 549 ?   ?   ?   D . n 
D 2 218 ASN 218 550 ?   ?   ?   D . n 
D 2 219 ASP 219 551 ?   ?   ?   D . n 
D 2 220 ILE 220 552 ?   ?   ?   D . n 
D 2 221 PHE 221 553 ?   ?   ?   D . n 
D 2 222 GLU 222 554 ?   ?   ?   D . n 
D 2 223 ALA 223 555 ?   ?   ?   D . n 
D 2 224 GLN 224 556 ?   ?   ?   D . n 
D 2 225 LYS 225 557 ?   ?   ?   D . n 
D 2 226 ILE 226 558 ?   ?   ?   D . n 
D 2 227 GLU 227 559 ?   ?   ?   D . n 
D 2 228 TRP 228 560 ?   ?   ?   D . n 
D 2 229 HIS 229 561 ?   ?   ?   D . n 
D 2 230 GLU 230 562 ?   ?   ?   D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 NAG 1  601 601 NAG NAG B . 
F 4 GOL 1  602 602 GOL GOL B . 
G 4 GOL 1  603 603 GOL GOL B . 
H 4 GOL 1  604 604 GOL GOL B . 
I 4 GOL 1  101 143 GOL GOL C . 
J 4 GOL 1  601 101 GOL GOL D . 
K 3 NAG 1  602 601 NAG NAG D . 
L 5 HOH 1  101 110 HOH HOH A . 
L 5 HOH 2  102 132 HOH HOH A . 
L 5 HOH 3  103 66  HOH HOH A . 
L 5 HOH 4  104 98  HOH HOH A . 
L 5 HOH 5  105 1   HOH HOH A . 
L 5 HOH 6  106 69  HOH HOH A . 
L 5 HOH 7  107 108 HOH HOH A . 
L 5 HOH 8  108 52  HOH HOH A . 
L 5 HOH 9  109 34  HOH HOH A . 
L 5 HOH 10 110 123 HOH HOH A . 
L 5 HOH 11 111 20  HOH HOH A . 
L 5 HOH 12 112 135 HOH HOH A . 
L 5 HOH 13 113 78  HOH HOH A . 
L 5 HOH 14 114 130 HOH HOH A . 
L 5 HOH 15 115 19  HOH HOH A . 
M 5 HOH 1  701 55  HOH HOH B . 
M 5 HOH 2  702 21  HOH HOH B . 
M 5 HOH 3  703 39  HOH HOH B . 
M 5 HOH 4  704 93  HOH HOH B . 
M 5 HOH 5  705 46  HOH HOH B . 
M 5 HOH 6  706 16  HOH HOH B . 
M 5 HOH 7  707 122 HOH HOH B . 
M 5 HOH 8  708 25  HOH HOH B . 
M 5 HOH 9  709 136 HOH HOH B . 
M 5 HOH 10 710 27  HOH HOH B . 
M 5 HOH 11 711 89  HOH HOH B . 
M 5 HOH 12 712 79  HOH HOH B . 
M 5 HOH 13 713 32  HOH HOH B . 
M 5 HOH 14 714 82  HOH HOH B . 
M 5 HOH 15 715 59  HOH HOH B . 
M 5 HOH 16 716 10  HOH HOH B . 
M 5 HOH 17 717 48  HOH HOH B . 
M 5 HOH 18 718 74  HOH HOH B . 
M 5 HOH 19 719 29  HOH HOH B . 
M 5 HOH 20 720 24  HOH HOH B . 
M 5 HOH 21 721 35  HOH HOH B . 
M 5 HOH 22 722 20  HOH HOH B . 
M 5 HOH 23 723 76  HOH HOH B . 
M 5 HOH 24 724 1   HOH HOH B . 
M 5 HOH 25 725 104 HOH HOH B . 
M 5 HOH 26 726 26  HOH HOH B . 
M 5 HOH 27 727 70  HOH HOH B . 
M 5 HOH 28 728 47  HOH HOH B . 
M 5 HOH 29 729 38  HOH HOH B . 
M 5 HOH 30 730 100 HOH HOH B . 
M 5 HOH 31 731 14  HOH HOH B . 
M 5 HOH 32 732 4   HOH HOH B . 
M 5 HOH 33 733 107 HOH HOH B . 
M 5 HOH 34 734 40  HOH HOH B . 
M 5 HOH 35 735 6   HOH HOH B . 
M 5 HOH 36 736 7   HOH HOH B . 
M 5 HOH 37 737 102 HOH HOH B . 
M 5 HOH 38 738 75  HOH HOH B . 
M 5 HOH 39 739 37  HOH HOH B . 
M 5 HOH 40 740 64  HOH HOH B . 
M 5 HOH 41 741 9   HOH HOH B . 
M 5 HOH 42 742 97  HOH HOH B . 
M 5 HOH 43 743 67  HOH HOH B . 
M 5 HOH 44 744 129 HOH HOH B . 
M 5 HOH 45 745 33  HOH HOH B . 
M 5 HOH 46 746 60  HOH HOH B . 
M 5 HOH 47 747 21  HOH HOH B . 
M 5 HOH 48 748 133 HOH HOH B . 
M 5 HOH 49 749 119 HOH HOH B . 
M 5 HOH 50 750 65  HOH HOH B . 
M 5 HOH 51 751 128 HOH HOH B . 
M 5 HOH 52 752 23  HOH HOH B . 
M 5 HOH 53 753 125 HOH HOH B . 
M 5 HOH 54 754 24  HOH HOH B . 
M 5 HOH 55 755 134 HOH HOH B . 
M 5 HOH 56 756 126 HOH HOH B . 
M 5 HOH 57 757 29  HOH HOH B . 
M 5 HOH 58 758 124 HOH HOH B . 
M 5 HOH 59 759 99  HOH HOH B . 
M 5 HOH 60 760 131 HOH HOH B . 
M 5 HOH 61 761 101 HOH HOH B . 
M 5 HOH 62 762 137 HOH HOH B . 
N 5 HOH 1  201 138 HOH HOH C . 
N 5 HOH 2  202 141 HOH HOH C . 
N 5 HOH 3  203 96  HOH HOH C . 
N 5 HOH 4  204 139 HOH HOH C . 
N 5 HOH 5  205 31  HOH HOH C . 
N 5 HOH 6  206 142 HOH HOH C . 
N 5 HOH 7  207 63  HOH HOH C . 
N 5 HOH 8  208 31  HOH HOH C . 
N 5 HOH 9  209 26  HOH HOH C . 
N 5 HOH 10 210 112 HOH HOH C . 
N 5 HOH 11 211 140 HOH HOH C . 
N 5 HOH 12 212 103 HOH HOH C . 
N 5 HOH 13 213 91  HOH HOH C . 
O 5 HOH 1  701 19  HOH HOH D . 
O 5 HOH 2  702 15  HOH HOH D . 
O 5 HOH 3  703 12  HOH HOH D . 
O 5 HOH 4  704 61  HOH HOH D . 
O 5 HOH 5  705 113 HOH HOH D . 
O 5 HOH 6  706 43  HOH HOH D . 
O 5 HOH 7  707 17  HOH HOH D . 
O 5 HOH 8  708 18  HOH HOH D . 
O 5 HOH 9  709 53  HOH HOH D . 
O 5 HOH 10 710 13  HOH HOH D . 
O 5 HOH 11 711 85  HOH HOH D . 
O 5 HOH 12 712 56  HOH HOH D . 
O 5 HOH 13 713 80  HOH HOH D . 
O 5 HOH 14 714 41  HOH HOH D . 
O 5 HOH 15 715 71  HOH HOH D . 
O 5 HOH 16 716 42  HOH HOH D . 
O 5 HOH 17 717 11  HOH HOH D . 
O 5 HOH 18 718 22  HOH HOH D . 
O 5 HOH 19 719 109 HOH HOH D . 
O 5 HOH 20 720 68  HOH HOH D . 
O 5 HOH 21 721 86  HOH HOH D . 
O 5 HOH 22 722 13  HOH HOH D . 
O 5 HOH 23 723 2   HOH HOH D . 
O 5 HOH 24 724 73  HOH HOH D . 
O 5 HOH 25 725 44  HOH HOH D . 
O 5 HOH 26 726 95  HOH HOH D . 
O 5 HOH 27 727 87  HOH HOH D . 
O 5 HOH 28 728 30  HOH HOH D . 
O 5 HOH 29 729 83  HOH HOH D . 
O 5 HOH 30 730 50  HOH HOH D . 
O 5 HOH 31 731 58  HOH HOH D . 
O 5 HOH 32 732 111 HOH HOH D . 
O 5 HOH 33 733 18  HOH HOH D . 
O 5 HOH 34 734 45  HOH HOH D . 
O 5 HOH 35 735 116 HOH HOH D . 
O 5 HOH 36 736 28  HOH HOH D . 
O 5 HOH 37 737 5   HOH HOH D . 
O 5 HOH 38 738 3   HOH HOH D . 
O 5 HOH 39 739 54  HOH HOH D . 
O 5 HOH 40 740 25  HOH HOH D . 
O 5 HOH 41 741 72  HOH HOH D . 
O 5 HOH 42 742 117 HOH HOH D . 
O 5 HOH 43 743 10  HOH HOH D . 
O 5 HOH 44 744 62  HOH HOH D . 
O 5 HOH 45 745 121 HOH HOH D . 
O 5 HOH 46 746 2   HOH HOH D . 
O 5 HOH 47 747 9   HOH HOH D . 
O 5 HOH 48 748 17  HOH HOH D . 
O 5 HOH 49 749 22  HOH HOH D . 
O 5 HOH 50 750 94  HOH HOH D . 
O 5 HOH 51 751 15  HOH HOH D . 
O 5 HOH 52 752 5   HOH HOH D . 
O 5 HOH 53 753 11  HOH HOH D . 
O 5 HOH 54 754 127 HOH HOH D . 
O 5 HOH 55 755 32  HOH HOH D . 
O 5 HOH 56 756 8   HOH HOH D . 
O 5 HOH 57 757 27  HOH HOH D . 
O 5 HOH 58 758 16  HOH HOH D . 
O 5 HOH 59 759 28  HOH HOH D . 
O 5 HOH 60 760 7   HOH HOH D . 
O 5 HOH 61 761 30  HOH HOH D . 
O 5 HOH 62 762 4   HOH HOH D . 
O 5 HOH 63 763 3   HOH HOH D . 
O 5 HOH 64 764 6   HOH HOH D . 
O 5 HOH 65 765 8   HOH HOH D . 
O 5 HOH 66 766 14  HOH HOH D . 
O 5 HOH 67 767 12  HOH HOH D . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 B LEU 532 ? CG  ? B LEU 200 CG  
2 1 Y 1 B LEU 532 ? CD1 ? B LEU 200 CD1 
3 1 Y 1 B LEU 532 ? CD2 ? B LEU 200 CD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YDP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     72.295 
_cell.length_a_esd                 ? 
_cell.length_b                     72.295 
_cell.length_b_esd                 ? 
_cell.length_c                     100.210 
_cell.length_c_esd                 ? 
_cell.volume                       453584.513 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YDP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                144 
_symmetry.space_group_name_Hall            'P 31' 
_symmetry.space_group_name_H-M             'P 31' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YDP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.22 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.52 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES (pH 7.5), 10% PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 2M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-09-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SLS BEAMLINE X06DA' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   X06DA 
_diffrn_source.pdbx_synchrotron_site       SLS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YDP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26011 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.81 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.151 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.30 
_reflns_shell.d_res_low                                     2.44 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4174 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.556 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.55 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YDP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             39.12 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25961 
_refine.ls_number_reflns_R_free                  1334 
_refine.ls_number_reflns_R_work                  24627 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.83 
_refine.ls_percent_reflns_R_free                 5.14 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2148 
_refine.ls_R_factor_R_free                       0.2631 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2122 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.96 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 30.4271 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3926 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        39.12 
_refine_hist.number_atoms_solvent             157 
_refine_hist.number_atoms_total               4018 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3803 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0018  ? 3952 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.4177  ? 5347 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0404  ? 560  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0032  ? 695  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.0669 ? 1432 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.30 2.38  . . 146 2437 99.23  . . . . 0.3406 . . . . . . . . . . . 0.3642 
'X-RAY DIFFRACTION' 2.38 2.48  . . 143 2457 99.88  . . . . 0.3215 . . . . . . . . . . . 0.3646 
'X-RAY DIFFRACTION' 2.48 2.59  . . 123 2492 99.92  . . . . 0.2845 . . . . . . . . . . . 0.3247 
'X-RAY DIFFRACTION' 2.59 2.73  . . 138 2438 99.84  . . . . 0.2655 . . . . . . . . . . . 0.3357 
'X-RAY DIFFRACTION' 2.73 2.90  . . 130 2469 99.85  . . . . 0.2414 . . . . . . . . . . . 0.3496 
'X-RAY DIFFRACTION' 2.90 3.12  . . 119 2479 99.73  . . . . 0.2565 . . . . . . . . . . . 0.2881 
'X-RAY DIFFRACTION' 3.12 3.44  . . 135 2475 100.00 . . . . 0.2264 . . . . . . . . . . . 0.2865 
'X-RAY DIFFRACTION' 3.44 3.93  . . 130 2438 99.96  . . . . 0.1869 . . . . . . . . . . . 0.2510 
'X-RAY DIFFRACTION' 3.93 4.95  . . 137 2471 99.96  . . . . 0.1697 . . . . . . . . . . . 0.2047 
'X-RAY DIFFRACTION' 4.96 39.12 . . 133 2471 99.92  . . . . 0.1831 . . . . . . . . . . . 0.2268 
# 
_struct.entry_id                     8YDP 
_struct.title                        
'Crystal structure of the receptor binding domain of SARS-CoV-2 spike protein in complex with Ce9' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YDP 
_struct_keywords.text            'RBD, VIRAL PROTEIN-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 3 ? 
L N N 5 ? 
M N N 5 ? 
N N N 5 ? 
O N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8YDP        8YDP   ? 1 ? 1   
2 UNP SPIKE_SARS2 P0DTC2 ? 2 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG
;
333 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YDP A 1 ? 39  ? 8YDP   1   ? 39  ? 1   39  
2 2 8YDP B 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
3 1 8YDP C 1 ? 39  ? 8YDP   1   ? 39  ? 1   39  
4 2 8YDP D 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8YDP SER B 195 ? UNP P0DTC2 ? ? 'expression tag' 527 1  
2 8YDP ASN B 196 ? UNP P0DTC2 ? ? 'expression tag' 528 2  
2 8YDP SER B 197 ? UNP P0DTC2 ? ? 'expression tag' 529 3  
2 8YDP GLU B 198 ? UNP P0DTC2 ? ? 'expression tag' 530 4  
2 8YDP ASN B 199 ? UNP P0DTC2 ? ? 'expression tag' 531 5  
2 8YDP LEU B 200 ? UNP P0DTC2 ? ? 'expression tag' 532 6  
2 8YDP TYR B 201 ? UNP P0DTC2 ? ? 'expression tag' 533 7  
2 8YDP PHE B 202 ? UNP P0DTC2 ? ? 'expression tag' 534 8  
2 8YDP GLN B 203 ? UNP P0DTC2 ? ? 'expression tag' 535 9  
2 8YDP GLY B 204 ? UNP P0DTC2 ? ? 'expression tag' 536 10 
2 8YDP SER B 205 ? UNP P0DTC2 ? ? 'expression tag' 537 11 
2 8YDP HIS B 206 ? UNP P0DTC2 ? ? 'expression tag' 538 12 
2 8YDP HIS B 207 ? UNP P0DTC2 ? ? 'expression tag' 539 13 
2 8YDP HIS B 208 ? UNP P0DTC2 ? ? 'expression tag' 540 14 
2 8YDP HIS B 209 ? UNP P0DTC2 ? ? 'expression tag' 541 15 
2 8YDP HIS B 210 ? UNP P0DTC2 ? ? 'expression tag' 542 16 
2 8YDP HIS B 211 ? UNP P0DTC2 ? ? 'expression tag' 543 17 
2 8YDP HIS B 212 ? UNP P0DTC2 ? ? 'expression tag' 544 18 
2 8YDP HIS B 213 ? UNP P0DTC2 ? ? 'expression tag' 545 19 
2 8YDP HIS B 214 ? UNP P0DTC2 ? ? 'expression tag' 546 20 
2 8YDP HIS B 215 ? UNP P0DTC2 ? ? 'expression tag' 547 21 
2 8YDP GLY B 216 ? UNP P0DTC2 ? ? 'expression tag' 548 22 
2 8YDP LEU B 217 ? UNP P0DTC2 ? ? 'expression tag' 549 23 
2 8YDP ASN B 218 ? UNP P0DTC2 ? ? 'expression tag' 550 24 
2 8YDP ASP B 219 ? UNP P0DTC2 ? ? 'expression tag' 551 25 
2 8YDP ILE B 220 ? UNP P0DTC2 ? ? 'expression tag' 552 26 
2 8YDP PHE B 221 ? UNP P0DTC2 ? ? 'expression tag' 553 27 
2 8YDP GLU B 222 ? UNP P0DTC2 ? ? 'expression tag' 554 28 
2 8YDP ALA B 223 ? UNP P0DTC2 ? ? 'expression tag' 555 29 
2 8YDP GLN B 224 ? UNP P0DTC2 ? ? 'expression tag' 556 30 
2 8YDP LYS B 225 ? UNP P0DTC2 ? ? 'expression tag' 557 31 
2 8YDP ILE B 226 ? UNP P0DTC2 ? ? 'expression tag' 558 32 
2 8YDP GLU B 227 ? UNP P0DTC2 ? ? 'expression tag' 559 33 
2 8YDP TRP B 228 ? UNP P0DTC2 ? ? 'expression tag' 560 34 
2 8YDP HIS B 229 ? UNP P0DTC2 ? ? 'expression tag' 561 35 
2 8YDP GLU B 230 ? UNP P0DTC2 ? ? 'expression tag' 562 36 
4 8YDP SER D 195 ? UNP P0DTC2 ? ? 'expression tag' 527 37 
4 8YDP ASN D 196 ? UNP P0DTC2 ? ? 'expression tag' 528 38 
4 8YDP SER D 197 ? UNP P0DTC2 ? ? 'expression tag' 529 39 
4 8YDP GLU D 198 ? UNP P0DTC2 ? ? 'expression tag' 530 40 
4 8YDP ASN D 199 ? UNP P0DTC2 ? ? 'expression tag' 531 41 
4 8YDP LEU D 200 ? UNP P0DTC2 ? ? 'expression tag' 532 42 
4 8YDP TYR D 201 ? UNP P0DTC2 ? ? 'expression tag' 533 43 
4 8YDP PHE D 202 ? UNP P0DTC2 ? ? 'expression tag' 534 44 
4 8YDP GLN D 203 ? UNP P0DTC2 ? ? 'expression tag' 535 45 
4 8YDP GLY D 204 ? UNP P0DTC2 ? ? 'expression tag' 536 46 
4 8YDP SER D 205 ? UNP P0DTC2 ? ? 'expression tag' 537 47 
4 8YDP HIS D 206 ? UNP P0DTC2 ? ? 'expression tag' 538 48 
4 8YDP HIS D 207 ? UNP P0DTC2 ? ? 'expression tag' 539 49 
4 8YDP HIS D 208 ? UNP P0DTC2 ? ? 'expression tag' 540 50 
4 8YDP HIS D 209 ? UNP P0DTC2 ? ? 'expression tag' 541 51 
4 8YDP HIS D 210 ? UNP P0DTC2 ? ? 'expression tag' 542 52 
4 8YDP HIS D 211 ? UNP P0DTC2 ? ? 'expression tag' 543 53 
4 8YDP HIS D 212 ? UNP P0DTC2 ? ? 'expression tag' 544 54 
4 8YDP HIS D 213 ? UNP P0DTC2 ? ? 'expression tag' 545 55 
4 8YDP HIS D 214 ? UNP P0DTC2 ? ? 'expression tag' 546 56 
4 8YDP HIS D 215 ? UNP P0DTC2 ? ? 'expression tag' 547 57 
4 8YDP GLY D 216 ? UNP P0DTC2 ? ? 'expression tag' 548 58 
4 8YDP LEU D 217 ? UNP P0DTC2 ? ? 'expression tag' 549 59 
4 8YDP ASN D 218 ? UNP P0DTC2 ? ? 'expression tag' 550 60 
4 8YDP ASP D 219 ? UNP P0DTC2 ? ? 'expression tag' 551 61 
4 8YDP ILE D 220 ? UNP P0DTC2 ? ? 'expression tag' 552 62 
4 8YDP PHE D 221 ? UNP P0DTC2 ? ? 'expression tag' 553 63 
4 8YDP GLU D 222 ? UNP P0DTC2 ? ? 'expression tag' 554 64 
4 8YDP ALA D 223 ? UNP P0DTC2 ? ? 'expression tag' 555 65 
4 8YDP GLN D 224 ? UNP P0DTC2 ? ? 'expression tag' 556 66 
4 8YDP LYS D 225 ? UNP P0DTC2 ? ? 'expression tag' 557 67 
4 8YDP ILE D 226 ? UNP P0DTC2 ? ? 'expression tag' 558 68 
4 8YDP GLU D 227 ? UNP P0DTC2 ? ? 'expression tag' 559 69 
4 8YDP TRP D 228 ? UNP P0DTC2 ? ? 'expression tag' 560 70 
4 8YDP HIS D 229 ? UNP P0DTC2 ? ? 'expression tag' 561 71 
4 8YDP GLU D 230 ? UNP P0DTC2 ? ? 'expression tag' 562 72 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2690  ? 
1 MORE         -4    ? 
1 'SSA (A^2)'  12130 ? 
2 'ABSA (A^2)' 2850  ? 
2 MORE         -3    ? 
2 'SSA (A^2)'  11600 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,H,L,M 
2 1 C,D,I,J,K,N,O   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 1   ? GLU A 19  ? ASP A 1   GLU A 19  1 ? 19 
HELX_P HELX_P2  AA2 HIS A 21  ? LYS A 37  ? HIS A 21  LYS A 37  1 ? 17 
HELX_P HELX_P3  AA3 ASP B 32  ? ASN B 38  ? ASP B 364 ASN B 370 1 ? 7  
HELX_P HELX_P4  AA4 SER B 51  ? ASP B 57  ? SER B 383 ASP B 389 5 ? 7  
HELX_P HELX_P5  AA5 ASP B 73  ? ILE B 78  ? ASP B 405 ILE B 410 5 ? 6  
HELX_P HELX_P6  AA6 GLY B 84  ? ASN B 90  ? GLY B 416 ASN B 422 1 ? 7  
HELX_P HELX_P7  AA7 GLY B 170 ? TYR B 173 ? GLY B 502 TYR B 505 5 ? 4  
HELX_P HELX_P8  AA8 LYS C 2   ? GLU C 19  ? LYS C 2   GLU C 19  1 ? 18 
HELX_P HELX_P9  AA9 HIS C 21  ? MET C 36  ? HIS C 21  MET C 36  1 ? 16 
HELX_P HELX_P10 AB1 PRO D 5   ? ASN D 11  ? PRO D 337 ASN D 343 1 ? 7  
HELX_P HELX_P11 AB2 SER D 17  ? TRP D 21  ? SER D 349 TRP D 353 5 ? 5  
HELX_P HELX_P12 AB3 ASP D 32  ? ASN D 38  ? ASP D 364 ASN D 370 1 ? 7  
HELX_P HELX_P13 AB4 THR D 53  ? ASP D 57  ? THR D 385 ASP D 389 5 ? 5  
HELX_P HELX_P14 AB5 ASP D 73  ? ILE D 78  ? ASP D 405 ILE D 410 5 ? 6  
HELX_P HELX_P15 AB6 GLY D 84  ? ASN D 90  ? GLY D 416 ASN D 422 1 ? 7  
HELX_P HELX_P16 AB7 SER D 106 ? SER D 111 ? SER D 438 SER D 443 1 ? 6  
HELX_P HELX_P17 AB8 GLY D 170 ? TYR D 173 ? GLY D 502 TYR D 505 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? B CYS 4   SG  ? ? ? 1_555 B CYS 29  SG ? ? B CYS 336 B CYS 361 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf2 disulf ?   ? B CYS 47  SG  ? ? ? 1_555 B CYS 100 SG ? ? B CYS 379 B CYS 432 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf3 disulf ?   ? B CYS 59  SG  ? ? ? 1_555 B CYS 193 SG ? ? B CYS 391 B CYS 525 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf4 disulf ?   ? B CYS 148 SG  ? ? ? 1_555 B CYS 156 SG ? ? B CYS 480 B CYS 488 1_555 ? ? ? ? ? ? ? 2.035 ? ?               
disulf5 disulf ?   ? D CYS 4   SG  ? ? ? 1_555 D CYS 29  SG ? ? D CYS 336 D CYS 361 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf6 disulf ?   ? D CYS 47  SG  ? ? ? 1_555 D CYS 100 SG ? ? D CYS 379 D CYS 432 1_555 ? ? ? ? ? ? ? 2.034 ? ?               
disulf7 disulf ?   ? D CYS 59  SG  ? ? ? 1_555 D CYS 193 SG ? ? D CYS 391 D CYS 525 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf8 disulf ?   ? D CYS 148 SG  ? ? ? 1_555 D CYS 156 SG ? ? D CYS 480 D CYS 488 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
covale1 covale one ? B ASN 11  ND2 ? ? ? 1_555 E NAG .   C1 ? ? B ASN 343 B NAG 601 1_555 ? ? ? ? ? ? ? 1.447 ? N-Glycosylation 
covale2 covale one ? D ASN 11  ND2 ? ? ? 1_555 K NAG .   C1 ? ? D ASN 343 D NAG 602 1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG E .   ? ASN B 11  ? NAG B 601 ? 1_555 ASN B 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG K .   ? ASN D 11  ? NAG D 602 ? 1_555 ASN D 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  CYS B 4   ? CYS B 29  ? CYS B 336 ? 1_555 CYS B 361 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS B 47  ? CYS B 100 ? CYS B 379 ? 1_555 CYS B 432 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS B 59  ? CYS B 193 ? CYS B 391 ? 1_555 CYS B 525 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS B 148 ? CYS B 156 ? CYS B 480 ? 1_555 CYS B 488 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS D 4   ? CYS D 29  ? CYS D 336 ? 1_555 CYS D 361 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS D 47  ? CYS D 100 ? CYS D 379 ? 1_555 CYS D 432 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS D 59  ? CYS D 193 ? CYS D 391 ? 1_555 CYS D 525 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS D 148 ? CYS D 156 ? CYS D 480 ? 1_555 CYS D 488 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
AA7 ? 2 ? 
AA8 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN B 22  ? ILE B 26  ? ASN B 354 ILE B 358 
AA1 2 ASN B 62  ? ARG B 71  ? ASN B 394 ARG B 403 
AA1 3 PRO B 175 ? GLU B 184 ? PRO B 507 GLU B 516 
AA1 4 GLY B 99  ? ASN B 105 ? GLY B 431 ASN B 437 
AA1 5 THR B 44  ? TYR B 48  ? THR B 376 TYR B 380 
AA2 1 CYS B 29  ? ALA B 31  ? CYS B 361 ALA B 363 
AA2 2 VAL B 192 ? GLY B 194 ? VAL B 524 GLY B 526 
AA2 3 CYS B 59  ? PHE B 60  ? CYS B 391 PHE B 392 
AA3 1 LEU B 120 ? ARG B 122 ? LEU B 452 ARG B 454 
AA3 2 LEU B 160 ? SER B 162 ? LEU B 492 SER B 494 
AA4 1 TYR B 141 ? GLN B 142 ? TYR B 473 GLN B 474 
AA4 2 CYS B 156 ? TYR B 157 ? CYS B 488 TYR B 489 
AA5 1 ASN D 22  ? ILE D 26  ? ASN D 354 ILE D 358 
AA5 2 ASN D 62  ? ARG D 71  ? ASN D 394 ARG D 403 
AA5 3 PRO D 175 ? GLU D 184 ? PRO D 507 GLU D 516 
AA5 4 GLY D 99  ? ASN D 105 ? GLY D 431 ASN D 437 
AA5 5 THR D 44  ? TYR D 48  ? THR D 376 TYR D 380 
AA6 1 CYS D 29  ? VAL D 30  ? CYS D 361 VAL D 362 
AA6 2 VAL D 192 ? CYS D 193 ? VAL D 524 CYS D 525 
AA6 3 CYS D 59  ? PHE D 60  ? CYS D 391 PHE D 392 
AA7 1 LEU D 120 ? ARG D 122 ? LEU D 452 ARG D 454 
AA7 2 LEU D 160 ? SER D 162 ? LEU D 492 SER D 494 
AA8 1 TYR D 141 ? GLN D 142 ? TYR D 473 GLN D 474 
AA8 2 CYS D 156 ? TYR D 157 ? CYS D 488 TYR D 489 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE B 26  ? N ILE B 358 O VAL B 63  ? O VAL B 395 
AA1 2 3 N ASP B 66  ? N ASP B 398 O VAL B 180 ? O VAL B 512 
AA1 3 4 O VAL B 179 ? O VAL B 511 N ILE B 102 ? N ILE B 434 
AA1 4 5 O GLY B 99  ? O GLY B 431 N TYR B 48  ? N TYR B 380 
AA2 1 2 N ALA B 31  ? N ALA B 363 O CYS B 193 ? O CYS B 525 
AA2 2 3 O VAL B 192 ? O VAL B 524 N PHE B 60  ? N PHE B 392 
AA3 1 2 N TYR B 121 ? N TYR B 453 O GLN B 161 ? O GLN B 493 
AA4 1 2 N TYR B 141 ? N TYR B 473 O TYR B 157 ? O TYR B 489 
AA5 1 2 N ILE D 26  ? N ILE D 358 O VAL D 63  ? O VAL D 395 
AA5 2 3 N ASP D 66  ? N ASP D 398 O VAL D 180 ? O VAL D 512 
AA5 3 4 O VAL D 179 ? O VAL D 511 N ILE D 102 ? N ILE D 434 
AA5 4 5 O GLY D 99  ? O GLY D 431 N TYR D 48  ? N TYR D 380 
AA6 1 2 N CYS D 29  ? N CYS D 361 O CYS D 193 ? O CYS D 525 
AA6 2 3 O VAL D 192 ? O VAL D 524 N PHE D 60  ? N PHE D 392 
AA7 1 2 N TYR D 121 ? N TYR D 453 O GLN D 161 ? O GLN D 493 
AA8 1 2 N TYR D 141 ? N TYR D 473 O TYR D 157 ? O TYR D 489 
# 
_pdbx_entry_details.entry_id                   8YDP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 37  ? ? -96.70  46.37  
2  1 ALA B 352 ? ? -110.31 53.91  
3  1 SER B 371 ? ? -62.74  90.39  
4  1 SER B 373 ? ? 57.01   90.49  
5  1 PHE B 377 ? ? -159.26 75.20  
6  1 ASN B 422 ? ? -123.90 -53.75 
7  1 ASP B 428 ? ? -86.79  33.81  
8  1 GLU B 530 ? ? -81.69  36.41  
9  1 PHE D 377 ? ? -151.69 64.87  
10 1 ASP D 428 ? ? -91.23  39.75  
11 1 THR D 470 ? ? -107.84 42.18  
12 1 LEU D 517 ? ? -112.37 65.94  
13 1 ASN D 528 ? ? -117.29 65.32  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z         
2 -y,x-y,z+1/3  
3 -x+y,-x,z+2/3 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B THR 333 ? B THR 1   
2  1 Y 1 B TYR 533 ? B TYR 201 
3  1 Y 1 B PHE 534 ? B PHE 202 
4  1 Y 1 B GLN 535 ? B GLN 203 
5  1 Y 1 B GLY 536 ? B GLY 204 
6  1 Y 1 B SER 537 ? B SER 205 
7  1 Y 1 B HIS 538 ? B HIS 206 
8  1 Y 1 B HIS 539 ? B HIS 207 
9  1 Y 1 B HIS 540 ? B HIS 208 
10 1 Y 1 B HIS 541 ? B HIS 209 
11 1 Y 1 B HIS 542 ? B HIS 210 
12 1 Y 1 B HIS 543 ? B HIS 211 
13 1 Y 1 B HIS 544 ? B HIS 212 
14 1 Y 1 B HIS 545 ? B HIS 213 
15 1 Y 1 B HIS 546 ? B HIS 214 
16 1 Y 1 B HIS 547 ? B HIS 215 
17 1 Y 1 B GLY 548 ? B GLY 216 
18 1 Y 1 B LEU 549 ? B LEU 217 
19 1 Y 1 B ASN 550 ? B ASN 218 
20 1 Y 1 B ASP 551 ? B ASP 219 
21 1 Y 1 B ILE 552 ? B ILE 220 
22 1 Y 1 B PHE 553 ? B PHE 221 
23 1 Y 1 B GLU 554 ? B GLU 222 
24 1 Y 1 B ALA 555 ? B ALA 223 
25 1 Y 1 B GLN 556 ? B GLN 224 
26 1 Y 1 B LYS 557 ? B LYS 225 
27 1 Y 1 B ILE 558 ? B ILE 226 
28 1 Y 1 B GLU 559 ? B GLU 227 
29 1 Y 1 B TRP 560 ? B TRP 228 
30 1 Y 1 B HIS 561 ? B HIS 229 
31 1 Y 1 B GLU 562 ? B GLU 230 
32 1 Y 1 D THR 333 ? D THR 1   
33 1 Y 1 D ASN 531 ? D ASN 199 
34 1 Y 1 D LEU 532 ? D LEU 200 
35 1 Y 1 D TYR 533 ? D TYR 201 
36 1 Y 1 D PHE 534 ? D PHE 202 
37 1 Y 1 D GLN 535 ? D GLN 203 
38 1 Y 1 D GLY 536 ? D GLY 204 
39 1 Y 1 D SER 537 ? D SER 205 
40 1 Y 1 D HIS 538 ? D HIS 206 
41 1 Y 1 D HIS 539 ? D HIS 207 
42 1 Y 1 D HIS 540 ? D HIS 208 
43 1 Y 1 D HIS 541 ? D HIS 209 
44 1 Y 1 D HIS 542 ? D HIS 210 
45 1 Y 1 D HIS 543 ? D HIS 211 
46 1 Y 1 D HIS 544 ? D HIS 212 
47 1 Y 1 D HIS 545 ? D HIS 213 
48 1 Y 1 D HIS 546 ? D HIS 214 
49 1 Y 1 D HIS 547 ? D HIS 215 
50 1 Y 1 D GLY 548 ? D GLY 216 
51 1 Y 1 D LEU 549 ? D LEU 217 
52 1 Y 1 D ASN 550 ? D ASN 218 
53 1 Y 1 D ASP 551 ? D ASP 219 
54 1 Y 1 D ILE 552 ? D ILE 220 
55 1 Y 1 D PHE 553 ? D PHE 221 
56 1 Y 1 D GLU 554 ? D GLU 222 
57 1 Y 1 D ALA 555 ? D ALA 223 
58 1 Y 1 D GLN 556 ? D GLN 224 
59 1 Y 1 D LYS 557 ? D LYS 225 
60 1 Y 1 D ILE 558 ? D ILE 226 
61 1 Y 1 D GLU 559 ? D GLU 227 
62 1 Y 1 D TRP 560 ? D TRP 228 
63 1 Y 1 D HIS 561 ? D HIS 229 
64 1 Y 1 D GLU 562 ? D GLU 230 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
NAG C1   C N R 264 
NAG C2   C N R 265 
NAG C3   C N R 266 
NAG C4   C N S 267 
NAG C5   C N R 268 
NAG C6   C N N 269 
NAG C7   C N N 270 
NAG C8   C N N 271 
NAG N2   N N N 272 
NAG O1   O N N 273 
NAG O3   O N N 274 
NAG O4   O N N 275 
NAG O5   O N N 276 
NAG O6   O N N 277 
NAG O7   O N N 278 
NAG H1   H N N 279 
NAG H2   H N N 280 
NAG H3   H N N 281 
NAG H4   H N N 282 
NAG H5   H N N 283 
NAG H61  H N N 284 
NAG H62  H N N 285 
NAG H81  H N N 286 
NAG H82  H N N 287 
NAG H83  H N N 288 
NAG HN2  H N N 289 
NAG HO1  H N N 290 
NAG HO3  H N N 291 
NAG HO4  H N N 292 
NAG HO6  H N N 293 
PHE N    N N N 294 
PHE CA   C N S 295 
PHE C    C N N 296 
PHE O    O N N 297 
PHE CB   C N N 298 
PHE CG   C Y N 299 
PHE CD1  C Y N 300 
PHE CD2  C Y N 301 
PHE CE1  C Y N 302 
PHE CE2  C Y N 303 
PHE CZ   C Y N 304 
PHE OXT  O N N 305 
PHE H    H N N 306 
PHE H2   H N N 307 
PHE HA   H N N 308 
PHE HB2  H N N 309 
PHE HB3  H N N 310 
PHE HD1  H N N 311 
PHE HD2  H N N 312 
PHE HE1  H N N 313 
PHE HE2  H N N 314 
PHE HZ   H N N 315 
PHE HXT  H N N 316 
PRO N    N N N 317 
PRO CA   C N S 318 
PRO C    C N N 319 
PRO O    O N N 320 
PRO CB   C N N 321 
PRO CG   C N N 322 
PRO CD   C N N 323 
PRO OXT  O N N 324 
PRO H    H N N 325 
PRO HA   H N N 326 
PRO HB2  H N N 327 
PRO HB3  H N N 328 
PRO HG2  H N N 329 
PRO HG3  H N N 330 
PRO HD2  H N N 331 
PRO HD3  H N N 332 
PRO HXT  H N N 333 
SER N    N N N 334 
SER CA   C N S 335 
SER C    C N N 336 
SER O    O N N 337 
SER CB   C N N 338 
SER OG   O N N 339 
SER OXT  O N N 340 
SER H    H N N 341 
SER H2   H N N 342 
SER HA   H N N 343 
SER HB2  H N N 344 
SER HB3  H N N 345 
SER HG   H N N 346 
SER HXT  H N N 347 
THR N    N N N 348 
THR CA   C N S 349 
THR C    C N N 350 
THR O    O N N 351 
THR CB   C N R 352 
THR OG1  O N N 353 
THR CG2  C N N 354 
THR OXT  O N N 355 
THR H    H N N 356 
THR H2   H N N 357 
THR HA   H N N 358 
THR HB   H N N 359 
THR HG1  H N N 360 
THR HG21 H N N 361 
THR HG22 H N N 362 
THR HG23 H N N 363 
THR HXT  H N N 364 
TRP N    N N N 365 
TRP CA   C N S 366 
TRP C    C N N 367 
TRP O    O N N 368 
TRP CB   C N N 369 
TRP CG   C Y N 370 
TRP CD1  C Y N 371 
TRP CD2  C Y N 372 
TRP NE1  N Y N 373 
TRP CE2  C Y N 374 
TRP CE3  C Y N 375 
TRP CZ2  C Y N 376 
TRP CZ3  C Y N 377 
TRP CH2  C Y N 378 
TRP OXT  O N N 379 
TRP H    H N N 380 
TRP H2   H N N 381 
TRP HA   H N N 382 
TRP HB2  H N N 383 
TRP HB3  H N N 384 
TRP HD1  H N N 385 
TRP HE1  H N N 386 
TRP HE3  H N N 387 
TRP HZ2  H N N 388 
TRP HZ3  H N N 389 
TRP HH2  H N N 390 
TRP HXT  H N N 391 
TYR N    N N N 392 
TYR CA   C N S 393 
TYR C    C N N 394 
TYR O    O N N 395 
TYR CB   C N N 396 
TYR CG   C Y N 397 
TYR CD1  C Y N 398 
TYR CD2  C Y N 399 
TYR CE1  C Y N 400 
TYR CE2  C Y N 401 
TYR CZ   C Y N 402 
TYR OH   O N N 403 
TYR OXT  O N N 404 
TYR H    H N N 405 
TYR H2   H N N 406 
TYR HA   H N N 407 
TYR HB2  H N N 408 
TYR HB3  H N N 409 
TYR HD1  H N N 410 
TYR HD2  H N N 411 
TYR HE1  H N N 412 
TYR HE2  H N N 413 
TYR HH   H N N 414 
TYR HXT  H N N 415 
VAL N    N N N 416 
VAL CA   C N S 417 
VAL C    C N N 418 
VAL O    O N N 419 
VAL CB   C N N 420 
VAL CG1  C N N 421 
VAL CG2  C N N 422 
VAL OXT  O N N 423 
VAL H    H N N 424 
VAL H2   H N N 425 
VAL HA   H N N 426 
VAL HB   H N N 427 
VAL HG11 H N N 428 
VAL HG12 H N N 429 
VAL HG13 H N N 430 
VAL HG21 H N N 431 
VAL HG22 H N N 432 
VAL HG23 H N N 433 
VAL HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
NAG C1  C2   sing N N 250 
NAG C1  O1   sing N N 251 
NAG C1  O5   sing N N 252 
NAG C1  H1   sing N N 253 
NAG C2  C3   sing N N 254 
NAG C2  N2   sing N N 255 
NAG C2  H2   sing N N 256 
NAG C3  C4   sing N N 257 
NAG C3  O3   sing N N 258 
NAG C3  H3   sing N N 259 
NAG C4  C5   sing N N 260 
NAG C4  O4   sing N N 261 
NAG C4  H4   sing N N 262 
NAG C5  C6   sing N N 263 
NAG C5  O5   sing N N 264 
NAG C5  H5   sing N N 265 
NAG C6  O6   sing N N 266 
NAG C6  H61  sing N N 267 
NAG C6  H62  sing N N 268 
NAG C7  C8   sing N N 269 
NAG C7  N2   sing N N 270 
NAG C7  O7   doub N N 271 
NAG C8  H81  sing N N 272 
NAG C8  H82  sing N N 273 
NAG C8  H83  sing N N 274 
NAG N2  HN2  sing N N 275 
NAG O1  HO1  sing N N 276 
NAG O3  HO3  sing N N 277 
NAG O4  HO4  sing N N 278 
NAG O6  HO6  sing N N 279 
PHE N   CA   sing N N 280 
PHE N   H    sing N N 281 
PHE N   H2   sing N N 282 
PHE CA  C    sing N N 283 
PHE CA  CB   sing N N 284 
PHE CA  HA   sing N N 285 
PHE C   O    doub N N 286 
PHE C   OXT  sing N N 287 
PHE CB  CG   sing N N 288 
PHE CB  HB2  sing N N 289 
PHE CB  HB3  sing N N 290 
PHE CG  CD1  doub Y N 291 
PHE CG  CD2  sing Y N 292 
PHE CD1 CE1  sing Y N 293 
PHE CD1 HD1  sing N N 294 
PHE CD2 CE2  doub Y N 295 
PHE CD2 HD2  sing N N 296 
PHE CE1 CZ   doub Y N 297 
PHE CE1 HE1  sing N N 298 
PHE CE2 CZ   sing Y N 299 
PHE CE2 HE2  sing N N 300 
PHE CZ  HZ   sing N N 301 
PHE OXT HXT  sing N N 302 
PRO N   CA   sing N N 303 
PRO N   CD   sing N N 304 
PRO N   H    sing N N 305 
PRO CA  C    sing N N 306 
PRO CA  CB   sing N N 307 
PRO CA  HA   sing N N 308 
PRO C   O    doub N N 309 
PRO C   OXT  sing N N 310 
PRO CB  CG   sing N N 311 
PRO CB  HB2  sing N N 312 
PRO CB  HB3  sing N N 313 
PRO CG  CD   sing N N 314 
PRO CG  HG2  sing N N 315 
PRO CG  HG3  sing N N 316 
PRO CD  HD2  sing N N 317 
PRO CD  HD3  sing N N 318 
PRO OXT HXT  sing N N 319 
SER N   CA   sing N N 320 
SER N   H    sing N N 321 
SER N   H2   sing N N 322 
SER CA  C    sing N N 323 
SER CA  CB   sing N N 324 
SER CA  HA   sing N N 325 
SER C   O    doub N N 326 
SER C   OXT  sing N N 327 
SER CB  OG   sing N N 328 
SER CB  HB2  sing N N 329 
SER CB  HB3  sing N N 330 
SER OG  HG   sing N N 331 
SER OXT HXT  sing N N 332 
THR N   CA   sing N N 333 
THR N   H    sing N N 334 
THR N   H2   sing N N 335 
THR CA  C    sing N N 336 
THR CA  CB   sing N N 337 
THR CA  HA   sing N N 338 
THR C   O    doub N N 339 
THR C   OXT  sing N N 340 
THR CB  OG1  sing N N 341 
THR CB  CG2  sing N N 342 
THR CB  HB   sing N N 343 
THR OG1 HG1  sing N N 344 
THR CG2 HG21 sing N N 345 
THR CG2 HG22 sing N N 346 
THR CG2 HG23 sing N N 347 
THR OXT HXT  sing N N 348 
TRP N   CA   sing N N 349 
TRP N   H    sing N N 350 
TRP N   H2   sing N N 351 
TRP CA  C    sing N N 352 
TRP CA  CB   sing N N 353 
TRP CA  HA   sing N N 354 
TRP C   O    doub N N 355 
TRP C   OXT  sing N N 356 
TRP CB  CG   sing N N 357 
TRP CB  HB2  sing N N 358 
TRP CB  HB3  sing N N 359 
TRP CG  CD1  doub Y N 360 
TRP CG  CD2  sing Y N 361 
TRP CD1 NE1  sing Y N 362 
TRP CD1 HD1  sing N N 363 
TRP CD2 CE2  doub Y N 364 
TRP CD2 CE3  sing Y N 365 
TRP NE1 CE2  sing Y N 366 
TRP NE1 HE1  sing N N 367 
TRP CE2 CZ2  sing Y N 368 
TRP CE3 CZ3  doub Y N 369 
TRP CE3 HE3  sing N N 370 
TRP CZ2 CH2  doub Y N 371 
TRP CZ2 HZ2  sing N N 372 
TRP CZ3 CH2  sing Y N 373 
TRP CZ3 HZ3  sing N N 374 
TRP CH2 HH2  sing N N 375 
TRP OXT HXT  sing N N 376 
TYR N   CA   sing N N 377 
TYR N   H    sing N N 378 
TYR N   H2   sing N N 379 
TYR CA  C    sing N N 380 
TYR CA  CB   sing N N 381 
TYR CA  HA   sing N N 382 
TYR C   O    doub N N 383 
TYR C   OXT  sing N N 384 
TYR CB  CG   sing N N 385 
TYR CB  HB2  sing N N 386 
TYR CB  HB3  sing N N 387 
TYR CG  CD1  doub Y N 388 
TYR CG  CD2  sing Y N 389 
TYR CD1 CE1  sing Y N 390 
TYR CD1 HD1  sing N N 391 
TYR CD2 CE2  doub Y N 392 
TYR CD2 HD2  sing N N 393 
TYR CE1 CZ   doub Y N 394 
TYR CE1 HE1  sing N N 395 
TYR CE2 CZ   sing Y N 396 
TYR CE2 HE2  sing N N 397 
TYR CZ  OH   sing N N 398 
TYR OH  HH   sing N N 399 
TYR OXT HXT  sing N N 400 
VAL N   CA   sing N N 401 
VAL N   H    sing N N 402 
VAL N   H2   sing N N 403 
VAL CA  C    sing N N 404 
VAL CA  CB   sing N N 405 
VAL CA  HA   sing N N 406 
VAL C   O    doub N N 407 
VAL C   OXT  sing N N 408 
VAL CB  CG1  sing N N 409 
VAL CB  CG2  sing N N 410 
VAL CB  HB   sing N N 411 
VAL CG1 HG11 sing N N 412 
VAL CG1 HG12 sing N N 413 
VAL CG1 HG13 sing N N 414 
VAL CG2 HG21 sing N N 415 
VAL CG2 HG22 sing N N 416 
VAL CG2 HG23 sing N N 417 
VAL OXT HXT  sing N N 418 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan 'JP21fk0108462, JP21fk0108585, JP21ae0121028, JP18ae0101046' 1 
'Japan Society for the Promotion of Science (JSPS)'        Japan 20H00451                                                     2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7jzu 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31' 
_space_group.name_Hall        'P 31' 
_space_group.IT_number        144 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YDP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013832 
_atom_sites.fract_transf_matrix[1][2]   0.007986 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015972 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009979 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 1   ? 12.20591 -13.33660 19.82370  1.000 68.14063  ? 1   ASP A N   1 
ATOM   2    C CA  . ASP A 1 1   ? 12.53659 -12.81513 18.50239  1.000 71.67281  ? 1   ASP A CA  1 
ATOM   3    C C   . ASP A 1 1   ? 13.24930 -13.86128 17.65194  1.000 64.27434  ? 1   ASP A C   1 
ATOM   4    O O   . ASP A 1 1   ? 13.82744 -14.81354 18.17706  1.000 61.23425  ? 1   ASP A O   1 
ATOM   5    C CB  . ASP A 1 1   ? 13.40552 -11.56078 18.62189  1.000 76.58520  ? 1   ASP A CB  1 
ATOM   6    C CG  . ASP A 1 1   ? 14.64216 -11.78728 19.46896  1.000 70.51819  ? 1   ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 1   ? 14.51270 -12.37609 20.56255  1.000 72.63890  ? 1   ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 1   ? 15.74300 -11.38099 19.03989  1.000 70.13802  ? 1   ASP A OD2 1 
ATOM   9    N N   . LYS A 1 2   ? 13.20551 -13.67586 16.33034  1.000 58.04213  ? 2   LYS A N   1 
ATOM   10   C CA  . LYS A 1 2   ? 13.89007 -14.60426 15.43765  1.000 63.24480  ? 2   LYS A CA  1 
ATOM   11   C C   . LYS A 1 2   ? 15.40097 -14.54093 15.62008  1.000 61.25143  ? 2   LYS A C   1 
ATOM   12   O O   . LYS A 1 2   ? 16.09241 -15.54686 15.42032  1.000 53.80444  ? 2   LYS A O   1 
ATOM   13   C CB  . LYS A 1 2   ? 13.50926 -14.31254 13.98376  1.000 61.17274  ? 2   LYS A CB  1 
ATOM   14   C CG  . LYS A 1 2   ? 14.08584 -15.29731 12.97377  1.000 63.08355  ? 2   LYS A CG  1 
ATOM   15   C CD  . LYS A 1 2   ? 13.54774 -15.04949 11.56920  1.000 68.53125  ? 2   LYS A CD  1 
ATOM   16   C CE  . LYS A 1 2   ? 14.09179 -16.07398 10.57823  1.000 61.65310  ? 2   LYS A CE  1 
ATOM   17   N NZ  . LYS A 1 2   ? 13.47575 -15.94201 9.22613   1.000 58.25813  ? 2   LYS A NZ  1 
ATOM   18   N N   . GLU A 1 3   ? 15.92560 -13.37956 16.01748  1.000 64.67559  ? 3   GLU A N   1 
ATOM   19   C CA  . GLU A 1 3   ? 17.36933 -13.22820 16.16380  1.000 60.77066  ? 3   GLU A CA  1 
ATOM   20   C C   . GLU A 1 3   ? 17.91001 -14.09782 17.29315  1.000 54.03334  ? 3   GLU A C   1 
ATOM   21   O O   . GLU A 1 3   ? 18.93454 -14.77054 17.12898  1.000 53.39476  ? 3   GLU A O   1 
ATOM   22   C CB  . GLU A 1 3   ? 17.71610 -11.75752 16.39524  1.000 59.21576  ? 3   GLU A CB  1 
ATOM   23   C CG  . GLU A 1 3   ? 17.26189 -10.83345 15.27519  1.000 64.68760  ? 3   GLU A CG  1 
ATOM   24   C CD  . GLU A 1 3   ? 18.05267 -9.53953  15.22410  1.000 67.55857  ? 3   GLU A CD  1 
ATOM   25   O OE1 . GLU A 1 3   ? 19.21625 -9.53416  15.67903  1.000 69.30291  ? 3   GLU A OE1 1 
ATOM   26   O OE2 . GLU A 1 3   ? 17.51189 -8.52816  14.72770  1.000 69.31067  ? 3   GLU A OE2 1 
ATOM   27   N N   . TRP A 1 4   ? 17.23100 -14.10609 18.44211  1.000 56.76439  ? 4   TRP A N   1 
ATOM   28   C CA  . TRP A 1 4   ? 17.69365 -14.90909 19.56991  1.000 53.51452  ? 4   TRP A CA  1 
ATOM   29   C C   . TRP A 1 4   ? 17.54620 -16.39954 19.28700  1.000 47.98440  ? 4   TRP A C   1 
ATOM   30   O O   . TRP A 1 4   ? 18.40634 -17.19868 19.67464  1.000 50.82763  ? 4   TRP A O   1 
ATOM   31   C CB  . TRP A 1 4   ? 16.92617 -14.51554 20.83320  1.000 61.35421  ? 4   TRP A CB  1 
ATOM   32   C CG  . TRP A 1 4   ? 17.35930 -15.23219 22.08136  1.000 59.99466  ? 4   TRP A CG  1 
ATOM   33   C CD1 . TRP A 1 4   ? 18.44229 -14.94177 22.86160  1.000 59.15283  ? 4   TRP A CD1 1 
ATOM   34   C CD2 . TRP A 1 4   ? 16.70442 -16.34435 22.70324  1.000 57.13453  ? 4   TRP A CD2 1 
ATOM   35   N NE1 . TRP A 1 4   ? 18.50775 -15.81070 23.92370  1.000 58.21564  ? 4   TRP A NE1 1 
ATOM   36   C CE2 . TRP A 1 4   ? 17.45176 -16.68089 23.85104  1.000 61.47052  ? 4   TRP A CE2 1 
ATOM   37   C CE3 . TRP A 1 4   ? 15.56098 -17.09039 22.39974  1.000 54.16380  ? 4   TRP A CE3 1 
ATOM   38   C CZ2 . TRP A 1 4   ? 17.09289 -17.73180 24.69505  1.000 55.28891  ? 4   TRP A CZ2 1 
ATOM   39   C CZ3 . TRP A 1 4   ? 15.20653 -18.13430 23.23943  1.000 57.09224  ? 4   TRP A CZ3 1 
ATOM   40   C CH2 . TRP A 1 4   ? 15.97020 -18.44430 24.37271  1.000 56.38040  ? 4   TRP A CH2 1 
ATOM   41   N N   . ILE A 1 5   ? 16.46915 -16.79017 18.60507  1.000 47.71259  ? 5   ILE A N   1 
ATOM   42   C CA  . ILE A 1 5   ? 16.23078 -18.20372 18.32704  1.000 48.15251  ? 5   ILE A CA  1 
ATOM   43   C C   . ILE A 1 5   ? 17.28781 -18.75075 17.37472  1.000 49.69107  ? 5   ILE A C   1 
ATOM   44   O O   . ILE A 1 5   ? 17.84438 -19.83263 17.59667  1.000 50.03081  ? 5   ILE A O   1 
ATOM   45   C CB  . ILE A 1 5   ? 14.80970 -18.40628 17.77203  1.000 55.46199  ? 5   ILE A CB  1 
ATOM   46   C CG1 . ILE A 1 5   ? 13.78956 -18.37336 18.91018  1.000 54.65015  ? 5   ILE A CG1 1 
ATOM   47   C CG2 . ILE A 1 5   ? 14.71624 -19.70593 16.98988  1.000 52.65283  ? 5   ILE A CG2 1 
ATOM   48   C CD1 . ILE A 1 5   ? 14.08736 -19.36029 20.01372  1.000 56.16694  ? 5   ILE A CD1 1 
ATOM   49   N N   . LEU A 1 6   ? 17.57686 -18.01460 16.29817  1.000 48.92402  ? 6   LEU A N   1 
ATOM   50   C CA  . LEU A 1 6   ? 18.59046 -18.46116 15.34744  1.000 46.13133  ? 6   LEU A CA  1 
ATOM   51   C C   . LEU A 1 6   ? 19.93876 -18.64730 16.02835  1.000 46.99431  ? 6   LEU A C   1 
ATOM   52   O O   . LEU A 1 6   ? 20.67922 -19.58622 15.71096  1.000 49.25784  ? 6   LEU A O   1 
ATOM   53   C CB  . LEU A 1 6   ? 18.70627 -17.46326 14.19525  1.000 51.51826  ? 6   LEU A CB  1 
ATOM   54   C CG  . LEU A 1 6   ? 19.81068 -17.71630 13.16511  1.000 47.22912  ? 6   LEU A CG  1 
ATOM   55   C CD1 . LEU A 1 6   ? 19.62667 -19.06457 12.48988  1.000 42.11332  ? 6   LEU A CD1 1 
ATOM   56   C CD2 . LEU A 1 6   ? 19.84669 -16.59850 12.13472  1.000 44.59329  ? 6   LEU A CD2 1 
ATOM   57   N N   . GLN A 1 7   ? 20.26999 -17.76508 16.97440  1.000 46.19468  ? 7   GLN A N   1 
ATOM   58   C CA  . GLN A 1 7   ? 21.53125 -17.89153 17.69636  1.000 48.00213  ? 7   GLN A CA  1 
ATOM   59   C C   . GLN A 1 7   ? 21.59483 -19.20075 18.47294  1.000 44.29291  ? 7   GLN A C   1 
ATOM   60   O O   . GLN A 1 7   ? 22.62138 -19.89018 18.45779  1.000 41.17158  ? 7   GLN A O   1 
ATOM   61   C CB  . GLN A 1 7   ? 21.72010 -16.70136 18.63714  1.000 42.72762  ? 7   GLN A CB  1 
ATOM   62   C CG  . GLN A 1 7   ? 23.03732 -16.72148 19.38834  1.000 41.69404  ? 7   GLN A CG  1 
ATOM   63   C CD  . GLN A 1 7   ? 24.23374 -16.60040 18.46698  1.000 44.12027  ? 7   GLN A CD  1 
ATOM   64   O OE1 . GLN A 1 7   ? 24.17734 -15.91772 17.44491  1.000 52.34556  ? 7   GLN A OE1 1 
ATOM   65   N NE2 . GLN A 1 7   ? 25.32482 -17.26652 18.82247  1.000 44.63296  ? 7   GLN A NE2 1 
ATOM   66   N N   . LYS A 1 8   ? 20.50352 -19.56677 19.15024  1.000 44.51881  ? 8   LYS A N   1 
ATOM   67   C CA  . LYS A 1 8   ? 20.51419 -20.79163 19.94396  1.000 49.50017  ? 8   LYS A CA  1 
ATOM   68   C C   . LYS A 1 8   ? 20.54494 -22.02826 19.05414  1.000 47.02325  ? 8   LYS A C   1 
ATOM   69   O O   . LYS A 1 8   ? 21.18000 -23.03115 19.40004  1.000 45.00307  ? 8   LYS A O   1 
ATOM   70   C CB  . LYS A 1 8   ? 19.30503 -20.83102 20.87934  1.000 51.00360  ? 8   LYS A CB  1 
ATOM   71   C CG  . LYS A 1 8   ? 19.13005 -19.58498 21.74480  1.000 51.74132  ? 8   LYS A CG  1 
ATOM   72   C CD  . LYS A 1 8   ? 20.43527 -19.14554 22.40278  1.000 51.97710  ? 8   LYS A CD  1 
ATOM   73   C CE  . LYS A 1 8   ? 20.90729 -20.12941 23.46079  1.000 62.64296  ? 8   LYS A CE  1 
ATOM   74   N NZ  . LYS A 1 8   ? 22.22461 -19.72550 24.02793  1.000 63.00346  ? 8   LYS A NZ  1 
ATOM   75   N N   . ILE A 1 9   ? 19.86862 -21.97765 17.90419  1.000 46.58279  ? 9   ILE A N   1 
ATOM   76   C CA  . ILE A 1 9   ? 19.90239 -23.10725 16.97981  1.000 42.45613  ? 9   ILE A CA  1 
ATOM   77   C C   . ILE A 1 9   ? 21.29370 -23.26070 16.37811  1.000 39.72282  ? 9   ILE A C   1 
ATOM   78   O O   . ILE A 1 9   ? 21.78713 -24.38098 16.19781  1.000 37.00357  ? 9   ILE A O   1 
ATOM   79   C CB  . ILE A 1 9   ? 18.82661 -22.94322 15.89238  1.000 44.87864  ? 9   ILE A CB  1 
ATOM   80   C CG1 . ILE A 1 9   ? 17.44414 -22.80064 16.52840  1.000 44.18502  ? 9   ILE A CG1 1 
ATOM   81   C CG2 . ILE A 1 9   ? 18.84013 -24.13212 14.94847  1.000 48.82377  ? 9   ILE A CG2 1 
ATOM   82   C CD1 . ILE A 1 9   ? 16.32608 -22.65038 15.52319  1.000 48.36991  ? 9   ILE A CD1 1 
ATOM   83   N N   . TYR A 1 10  ? 21.95028 -22.14082 16.06314  1.000 38.43938  ? 10  TYR A N   1 
ATOM   84   C CA  . TYR A 1 10  ? 23.33466 -22.20227 15.60746  1.000 37.29347  ? 10  TYR A CA  1 
ATOM   85   C C   . TYR A 1 10  ? 24.23733 -22.80675 16.67623  1.000 41.42864  ? 10  TYR A C   1 
ATOM   86   O O   . TYR A 1 10  ? 25.10842 -23.63014 16.37039  1.000 39.22292  ? 10  TYR A O   1 
ATOM   87   C CB  . TYR A 1 10  ? 23.82607 -20.80669 15.21637  1.000 37.51464  ? 10  TYR A CB  1 
ATOM   88   C CG  . TYR A 1 10  ? 25.22086 -20.80310 14.62899  1.000 40.34340  ? 10  TYR A CG  1 
ATOM   89   C CD1 . TYR A 1 10  ? 25.42928 -21.07446 13.28040  1.000 38.53378  ? 10  TYR A CD1 1 
ATOM   90   C CD2 . TYR A 1 10  ? 26.32967 -20.54031 15.42199  1.000 42.09295  ? 10  TYR A CD2 1 
ATOM   91   C CE1 . TYR A 1 10  ? 26.70164 -21.07963 12.74085  1.000 38.63123  ? 10  TYR A CE1 1 
ATOM   92   C CE2 . TYR A 1 10  ? 27.60646 -20.54452 14.88991  1.000 45.58376  ? 10  TYR A CE2 1 
ATOM   93   C CZ  . TYR A 1 10  ? 27.78613 -20.81365 13.54951  1.000 44.02613  ? 10  TYR A CZ  1 
ATOM   94   O OH  . TYR A 1 10  ? 29.05677 -20.81758 13.01969  1.000 46.09373  ? 10  TYR A OH  1 
ATOM   95   N N   . GLU A 1 11  ? 24.03916 -22.41312 17.93900  1.000 42.96313  ? 11  GLU A N   1 
ATOM   96   C CA  . GLU A 1 11  ? 24.84638 -22.96295 19.02498  1.000 46.07053  ? 11  GLU A CA  1 
ATOM   97   C C   . GLU A 1 11  ? 24.60842 -24.45802 19.19104  1.000 40.41750  ? 11  GLU A C   1 
ATOM   98   O O   . GLU A 1 11  ? 25.54984 -25.21627 19.45004  1.000 40.89354  ? 11  GLU A O   1 
ATOM   99   C CB  . GLU A 1 11  ? 24.54958 -22.22479 20.33191  1.000 47.89357  ? 11  GLU A CB  1 
ATOM   100  C CG  . GLU A 1 11  ? 25.08993 -20.80517 20.37682  1.000 51.32944  ? 11  GLU A CG  1 
ATOM   101  C CD  . GLU A 1 11  ? 24.68466 -20.06196 21.63388  1.000 57.44182  ? 11  GLU A CD  1 
ATOM   102  O OE1 . GLU A 1 11  ? 24.01172 -20.66587 22.49654  1.000 57.37496  ? 11  GLU A OE1 1 
ATOM   103  O OE2 . GLU A 1 11  ? 25.03855 -18.86992 21.75735  1.000 59.20169  ? 11  GLU A OE2 1 
ATOM   104  N N   . ILE A 1 12  ? 23.35777 -24.90165 19.04417  1.000 35.80769  ? 12  ILE A N   1 
ATOM   105  C CA  . ILE A 1 12  ? 23.06135 -26.32917 19.14109  1.000 38.83327  ? 12  ILE A CA  1 
ATOM   106  C C   . ILE A 1 12  ? 23.85374 -27.10560 18.09725  1.000 39.52017  ? 12  ILE A C   1 
ATOM   107  O O   . ILE A 1 12  ? 24.49332 -28.11861 18.40468  1.000 41.65846  ? 12  ILE A O   1 
ATOM   108  C CB  . ILE A 1 12  ? 21.54813 -26.57798 19.00221  1.000 44.23384  ? 12  ILE A CB  1 
ATOM   109  C CG1 . ILE A 1 12  ? 20.80176 -26.05117 20.22915  1.000 44.84946  ? 12  ILE A CG1 1 
ATOM   110  C CG2 . ILE A 1 12  ? 21.26646 -28.06187 18.80233  1.000 36.82675  ? 12  ILE A CG2 1 
ATOM   111  C CD1 . ILE A 1 12  ? 19.30505 -26.25885 20.16867  1.000 43.51545  ? 12  ILE A CD1 1 
ATOM   112  N N   . MET A 1 13  ? 23.83238 -26.63088 16.84789  1.000 40.85531  ? 13  MET A N   1 
ATOM   113  C CA  . MET A 1 13  ? 24.58024 -27.28861 15.78036  1.000 35.62758  ? 13  MET A CA  1 
ATOM   114  C C   . MET A 1 13  ? 26.05816 -27.40352 16.13086  1.000 35.49780  ? 13  MET A C   1 
ATOM   115  O O   . MET A 1 13  ? 26.65541 -28.48008 16.01059  1.000 37.92438  ? 13  MET A O   1 
ATOM   116  C CB  . MET A 1 13  ? 24.39905 -26.52242 14.46814  1.000 42.11579  ? 13  MET A CB  1 
ATOM   117  C CG  . MET A 1 13  ? 25.26127 -27.04086 13.32797  1.000 41.02858  ? 13  MET A CG  1 
ATOM   118  S SD  . MET A 1 13  ? 25.20769 -26.00327 11.85479  1.000 56.49232  ? 13  MET A SD  1 
ATOM   119  C CE  . MET A 1 13  ? 25.98326 -24.50725 12.45921  1.000 48.50654  ? 13  MET A CE  1 
ATOM   120  N N   . ARG A 1 14  ? 26.66382 -26.29877 16.57179  1.000 34.09661  ? 14  ARG A N   1 
ATOM   121  C CA  . ARG A 1 14  ? 28.08619 -26.30804 16.90076  1.000 42.17653  ? 14  ARG A CA  1 
ATOM   122  C C   . ARG A 1 14  ? 28.38814 -27.30297 18.01491  1.000 47.45322  ? 14  ARG A C   1 
ATOM   123  O O   . ARG A 1 14  ? 29.33985 -28.08741 17.92081  1.000 48.22259  ? 14  ARG A O   1 
ATOM   124  C CB  . ARG A 1 14  ? 28.54045 -24.90310 17.29912  1.000 48.64531  ? 14  ARG A CB  1 
ATOM   125  C CG  . ARG A 1 14  ? 28.33110 -23.84921 16.22666  1.000 47.81024  ? 14  ARG A CG  1 
ATOM   126  C CD  . ARG A 1 14  ? 29.26333 -24.06519 15.04666  1.000 52.81469  ? 14  ARG A CD  1 
ATOM   127  N NE  . ARG A 1 14  ? 30.66493 -23.96354 15.43641  1.000 62.16040  ? 14  ARG A NE  1 
ATOM   128  C CZ  . ARG A 1 14  ? 31.68089 -23.95384 14.58392  1.000 66.28825  ? 14  ARG A CZ  1 
ATOM   129  N NH1 . ARG A 1 14  ? 31.48762 -24.02963 13.27683  1.000 60.21161  ? 14  ARG A NH1 1 
ATOM   130  N NH2 . ARG A 1 14  ? 32.92186 -23.86369 15.05435  1.000 65.00982  ? 14  ARG A NH2 1 
ATOM   131  N N   . ARG A 1 15  ? 27.58144 -27.28725 19.08111  1.000 46.63161  ? 15  ARG A N   1 
ATOM   132  C CA  . ARG A 1 15  ? 27.82654 -28.18889 20.20330  1.000 51.49776  ? 15  ARG A CA  1 
ATOM   133  C C   . ARG A 1 15  ? 27.66316 -29.64430 19.78594  1.000 49.89063  ? 15  ARG A C   1 
ATOM   134  O O   . ARG A 1 15  ? 28.44401 -30.50708 20.20346  1.000 53.12556  ? 15  ARG A O   1 
ATOM   135  C CB  . ARG A 1 15  ? 26.89006 -27.86116 21.36946  1.000 52.83868  ? 15  ARG A CB  1 
ATOM   136  C CG  . ARG A 1 15  ? 26.99971 -26.44262 21.92543  1.000 48.27104  ? 15  ARG A CG  1 
ATOM   137  C CD  . ARG A 1 15  ? 28.36818 -26.14435 22.52683  1.000 54.49582  ? 15  ARG A CD  1 
ATOM   138  N NE  . ARG A 1 15  ? 29.30529 -25.60193 21.54876  1.000 58.60917  ? 15  ARG A NE  1 
ATOM   139  C CZ  . ARG A 1 15  ? 29.31665 -24.34002 21.13844  1.000 58.25338  ? 15  ARG A CZ  1 
ATOM   140  N NH1 . ARG A 1 15  ? 28.43470 -23.45942 21.58322  1.000 56.67207  ? 15  ARG A NH1 1 
ATOM   141  N NH2 . ARG A 1 15  ? 30.23376 -23.95245 20.25630  1.000 56.53949  ? 15  ARG A NH2 1 
ATOM   142  N N   . LEU A 1 16  ? 26.65491 -29.93577 18.95970  1.000 40.64017  ? 16  LEU A N   1 
ATOM   143  C CA  . LEU A 1 16  ? 26.44694 -31.30667 18.50311  1.000 45.63812  ? 16  LEU A CA  1 
ATOM   144  C C   . LEU A 1 16  ? 27.67463 -31.84222 17.77799  1.000 49.58730  ? 16  LEU A C   1 
ATOM   145  O O   . LEU A 1 16  ? 28.05748 -33.00296 17.96549  1.000 51.57194  ? 16  LEU A O   1 
ATOM   146  C CB  . LEU A 1 16  ? 25.21837 -31.37832 17.59779  1.000 42.37099  ? 16  LEU A CB  1 
ATOM   147  C CG  . LEU A 1 16  ? 23.85694 -31.25300 18.27974  1.000 42.55315  ? 16  LEU A CG  1 
ATOM   148  C CD1 . LEU A 1 16  ? 22.76529 -31.09188 17.24236  1.000 36.47977  ? 16  LEU A CD1 1 
ATOM   149  C CD2 . LEU A 1 16  ? 23.58658 -32.46411 19.16323  1.000 45.49448  ? 16  LEU A CD2 1 
ATOM   150  N N   . ASP A 1 17  ? 28.30767 -31.01089 16.94626  1.000 47.26804  ? 17  ASP A N   1 
ATOM   151  C CA  . ASP A 1 17  ? 29.50917 -31.45208 16.24781  1.000 50.77505  ? 17  ASP A CA  1 
ATOM   152  C C   . ASP A 1 17  ? 30.68515 -31.60085 17.20335  1.000 52.95443  ? 17  ASP A C   1 
ATOM   153  O O   . ASP A 1 17  ? 31.54534 -32.46366 16.99669  1.000 60.45113  ? 17  ASP A O   1 
ATOM   154  C CB  . ASP A 1 17  ? 29.85540 -30.47508 15.12480  1.000 52.07900  ? 17  ASP A CB  1 
ATOM   155  C CG  . ASP A 1 17  ? 30.61496 -31.13704 13.99012  1.000 65.26093  ? 17  ASP A CG  1 
ATOM   156  O OD1 . ASP A 1 17  ? 30.81373 -32.37024 14.04505  1.000 65.64915  ? 17  ASP A OD1 1 
ATOM   157  O OD2 . ASP A 1 17  ? 31.00812 -30.42541 13.04073  1.000 66.57559  ? 17  ASP A OD2 1 
ATOM   158  N N   . GLU A 1 18  ? 30.73999 -30.77523 18.25003  1.000 51.67875  ? 18  GLU A N   1 
ATOM   159  C CA  . GLU A 1 18  ? 31.80661 -30.90549 19.23607  1.000 60.76841  ? 18  GLU A CA  1 
ATOM   160  C C   . GLU A 1 18  ? 31.65890 -32.17902 20.05899  1.000 59.30215  ? 18  GLU A C   1 
ATOM   161  O O   . GLU A 1 18  ? 32.65528 -32.70294 20.56910  1.000 62.35830  ? 18  GLU A O   1 
ATOM   162  C CB  . GLU A 1 18  ? 31.82998 -29.67737 20.14589  1.000 54.53242  ? 18  GLU A CB  1 
ATOM   163  C CG  . GLU A 1 18  ? 32.20753 -28.39132 19.42433  1.000 62.48059  ? 18  GLU A CG  1 
ATOM   164  C CD  . GLU A 1 18  ? 31.91568 -27.14984 20.24506  1.000 59.89529  ? 18  GLU A CD  1 
ATOM   165  O OE1 . GLU A 1 18  ? 31.34390 -27.28716 21.34703  1.000 56.90323  ? 18  GLU A OE1 1 
ATOM   166  O OE2 . GLU A 1 18  ? 32.25323 -26.03668 19.78581  1.000 61.67046  ? 18  GLU A OE2 1 
ATOM   167  N N   . GLU A 1 19  ? 30.43741 -32.69080 20.19642  1.000 56.25308  ? 19  GLU A N   1 
ATOM   168  C CA  . GLU A 1 19  ? 30.19027 -33.93845 20.90615  1.000 58.26246  ? 19  GLU A CA  1 
ATOM   169  C C   . GLU A 1 19  ? 30.34105 -35.16607 20.01794  1.000 60.50653  ? 19  GLU A C   1 
ATOM   170  O O   . GLU A 1 19  ? 30.08525 -36.28245 20.48172  1.000 66.15737  ? 19  GLU A O   1 
ATOM   171  C CB  . GLU A 1 19  ? 28.78661 -33.93418 21.52350  1.000 57.23125  ? 19  GLU A CB  1 
ATOM   172  C CG  . GLU A 1 19  ? 28.47390 -32.72791 22.39435  1.000 59.99641  ? 19  GLU A CG  1 
ATOM   173  C CD  . GLU A 1 19  ? 29.32658 -32.65647 23.64487  1.000 68.48758  ? 19  GLU A CD  1 
ATOM   174  O OE1 . GLU A 1 19  ? 29.87914 -33.69805 24.05994  1.000 74.11841  ? 19  GLU A OE1 1 
ATOM   175  O OE2 . GLU A 1 19  ? 29.44166 -31.55137 24.21482  1.000 71.22645  ? 19  GLU A OE2 1 
ATOM   176  N N   . GLY A 1 20  ? 30.73842 -34.99151 18.75836  1.000 58.64592  ? 20  GLY A N   1 
ATOM   177  C CA  . GLY A 1 20  ? 30.89400 -36.09875 17.84254  1.000 59.94650  ? 20  GLY A CA  1 
ATOM   178  C C   . GLY A 1 20  ? 29.63899 -36.50283 17.10028  1.000 55.58305  ? 20  GLY A C   1 
ATOM   179  O O   . GLY A 1 20  ? 29.71343 -37.36967 16.21994  1.000 56.91770  ? 20  GLY A O   1 
ATOM   180  N N   . HIS A 1 21  ? 28.48872 -35.91027 17.42548  1.000 52.98279  ? 21  HIS A N   1 
ATOM   181  C CA  . HIS A 1 21  ? 27.23445 -36.20232 16.73034  1.000 49.68807  ? 21  HIS A CA  1 
ATOM   182  C C   . HIS A 1 21  ? 27.21328 -35.43190 15.40882  1.000 48.54309  ? 21  HIS A C   1 
ATOM   183  O O   . HIS A 1 21  ? 26.51028 -34.43462 15.23102  1.000 45.26595  ? 21  HIS A O   1 
ATOM   184  C CB  . HIS A 1 21  ? 26.04013 -35.85055 17.60742  1.000 52.57590  ? 21  HIS A CB  1 
ATOM   185  C CG  . HIS A 1 21  ? 26.01344 -36.57594 18.91812  1.000 58.83055  ? 21  HIS A CG  1 
ATOM   186  N ND1 . HIS A 1 21  ? 26.93568 -36.34547 19.91651  1.000 62.18777  ? 21  HIS A ND1 1 
ATOM   187  C CD2 . HIS A 1 21  ? 25.17236 -37.52372 19.39595  1.000 60.17969  ? 21  HIS A CD2 1 
ATOM   188  C CE1 . HIS A 1 21  ? 26.66800 -37.12361 20.94988  1.000 65.04422  ? 21  HIS A CE1 1 
ATOM   189  N NE2 . HIS A 1 21  ? 25.60143 -37.84724 20.66064  1.000 66.57977  ? 21  HIS A NE2 1 
ATOM   190  N N   . ALA A 1 22  ? 28.01598 -35.92419 14.46346  1.000 49.06022  ? 22  ALA A N   1 
ATOM   191  C CA  . ALA A 1 22  ? 28.20636 -35.21409 13.20276  1.000 43.18141  ? 22  ALA A CA  1 
ATOM   192  C C   . ALA A 1 22  ? 26.91974 -35.17067 12.38750  1.000 41.44908  ? 22  ALA A C   1 
ATOM   193  O O   . ALA A 1 22  ? 26.53636 -34.11379 11.87161  1.000 42.04133  ? 22  ALA A O   1 
ATOM   194  C CB  . ALA A 1 22  ? 29.33260 -35.86748 12.40418  1.000 46.01554  ? 22  ALA A CB  1 
ATOM   195  N N   . GLU A 1 23  ? 26.23707 -36.31191 12.26352  1.000 40.61621  ? 23  GLU A N   1 
ATOM   196  C CA  . GLU A 1 23  ? 25.01439 -36.36457 11.46683  1.000 42.33294  ? 23  GLU A CA  1 
ATOM   197  C C   . GLU A 1 23  ? 23.93399 -35.45613 12.04059  1.000 43.44409  ? 23  GLU A C   1 
ATOM   198  O O   . GLU A 1 23  ? 23.19342 -34.80933 11.28970  1.000 40.32803  ? 23  GLU A O   1 
ATOM   199  C CB  . GLU A 1 23  ? 24.51219 -37.80480 11.37629  1.000 43.14535  ? 23  GLU A CB  1 
ATOM   200  C CG  . GLU A 1 23  ? 25.40390 -38.71651 10.55144  1.000 42.42548  ? 23  GLU A CG  1 
ATOM   201  C CD  . GLU A 1 23  ? 24.99907 -40.17188 10.65308  1.000 50.69639  ? 23  GLU A CD  1 
ATOM   202  O OE1 . GLU A 1 23  ? 24.92509 -40.68998 11.78896  1.000 48.32882  ? 23  GLU A OE1 1 
ATOM   203  O OE2 . GLU A 1 23  ? 24.74933 -40.79534 9.59839   1.000 53.40626  ? 23  GLU A OE2 1 
ATOM   204  N N   . ALA A 1 24  ? 23.82733 -35.39560 13.37078  1.000 40.05344  ? 24  ALA A N   1 
ATOM   205  C CA  . ALA A 1 24  ? 22.84694 -34.51284 13.99448  1.000 42.65759  ? 24  ALA A CA  1 
ATOM   206  C C   . ALA A 1 24  ? 23.21481 -33.04759 13.79452  1.000 42.50775  ? 24  ALA A C   1 
ATOM   207  O O   . ALA A 1 24  ? 22.33257 -32.19767 13.63148  1.000 43.44104  ? 24  ALA A O   1 
ATOM   208  C CB  . ALA A 1 24  ? 22.71874 -34.83611 15.48370  1.000 42.99166  ? 24  ALA A CB  1 
ATOM   209  N N   . SER A 1 25  ? 24.51160 -32.73184 13.80523  1.000 41.94879  ? 25  SER A N   1 
ATOM   210  C CA  . SER A 1 25  ? 24.93774 -31.35845 13.55796  1.000 39.79258  ? 25  SER A CA  1 
ATOM   211  C C   . SER A 1 25  ? 24.68816 -30.95713 12.10924  1.000 41.40973  ? 25  SER A C   1 
ATOM   212  O O   . SER A 1 25  ? 24.25624 -29.83066 11.83478  1.000 40.61773  ? 25  SER A O   1 
ATOM   213  C CB  . SER A 1 25  ? 26.41497 -31.19625 13.91539  1.000 44.06813  ? 25  SER A CB  1 
ATOM   214  O OG  . SER A 1 25  ? 26.82809 -29.84814 13.77579  1.000 45.07895  ? 25  SER A OG  1 
ATOM   215  N N   . MET A 1 26  ? 24.95193 -31.86449 11.16720  1.000 40.44176  ? 26  MET A N   1 
ATOM   216  C CA  . MET A 1 26  ? 24.65318 -31.57088 9.77014   1.000 40.88819  ? 26  MET A CA  1 
ATOM   217  C C   . MET A 1 26  ? 23.15274 -31.48071 9.52808   1.000 42.13054  ? 26  MET A C   1 
ATOM   218  O O   . MET A 1 26  ? 22.71039 -30.71405 8.66498   1.000 42.55856  ? 26  MET A O   1 
ATOM   219  C CB  . MET A 1 26  ? 25.28024 -32.62687 8.86031   1.000 36.88339  ? 26  MET A CB  1 
ATOM   220  C CG  . MET A 1 26  ? 26.78555 -32.49120 8.70638   1.000 39.26423  ? 26  MET A CG  1 
ATOM   221  S SD  . MET A 1 26  ? 27.48294 -33.65884 7.52179   1.000 48.58721  ? 26  MET A SD  1 
ATOM   222  C CE  . MET A 1 26  ? 27.22183 -35.21402 8.36946   1.000 41.05087  ? 26  MET A CE  1 
ATOM   223  N N   . ARG A 1 27  ? 22.35488 -32.24192 10.28011  1.000 41.52169  ? 27  ARG A N   1 
ATOM   224  C CA  . ARG A 1 27  ? 20.90781 -32.15882 10.11657  1.000 40.38715  ? 27  ARG A CA  1 
ATOM   225  C C   . ARG A 1 27  ? 20.37320 -30.82464 10.62499  1.000 42.38630  ? 27  ARG A C   1 
ATOM   226  O O   . ARG A 1 27  ? 19.49768 -30.21925 9.99440   1.000 38.90815  ? 27  ARG A O   1 
ATOM   227  C CB  . ARG A 1 27  ? 20.22686 -33.32305 10.83393  1.000 42.60165  ? 27  ARG A CB  1 
ATOM   228  C CG  . ARG A 1 27  ? 18.73446 -33.39194 10.58110  1.000 43.74790  ? 27  ARG A CG  1 
ATOM   229  C CD  . ARG A 1 27  ? 18.45365 -33.32684 9.08995   1.000 46.31247  ? 27  ARG A CD  1 
ATOM   230  N NE  . ARG A 1 27  ? 17.02815 -33.28222 8.79043   1.000 48.23886  ? 27  ARG A NE  1 
ATOM   231  C CZ  . ARG A 1 27  ? 16.52652 -32.96017 7.60598   1.000 51.45790  ? 27  ARG A CZ  1 
ATOM   232  N NH1 . ARG A 1 27  ? 17.30933 -32.63346 6.59003   1.000 42.56607  ? 27  ARG A NH1 1 
ATOM   233  N NH2 . ARG A 1 27  ? 15.20707 -32.96045 7.43802   1.000 57.80240  ? 27  ARG A NH2 1 
ATOM   234  N N   . VAL A 1 28  ? 20.88921 -30.35014 11.76250  1.000 38.19419  ? 28  VAL A N   1 
ATOM   235  C CA  . VAL A 1 28  ? 20.49157 -29.03905 12.26885  1.000 41.04903  ? 28  VAL A CA  1 
ATOM   236  C C   . VAL A 1 28  ? 20.93223 -27.94735 11.30501  1.000 36.29025  ? 28  VAL A C   1 
ATOM   237  O O   . VAL A 1 28  ? 20.23336 -26.94358 11.11817  1.000 38.32839  ? 28  VAL A O   1 
ATOM   238  C CB  . VAL A 1 28  ? 21.05641 -28.81622 13.68517  1.000 38.86947  ? 28  VAL A CB  1 
ATOM   239  C CG1 . VAL A 1 28  ? 20.75546 -27.40594 14.17058  1.000 32.41712  ? 28  VAL A CG1 1 
ATOM   240  C CG2 . VAL A 1 28  ? 20.48015 -29.84192 14.64492  1.000 36.11270  ? 28  VAL A CG2 1 
ATOM   241  N N   . SER A 1 29  ? 22.09395 -28.12895 10.67287  1.000 42.72942  ? 29  SER A N   1 
ATOM   242  C CA  . SER A 1 29  ? 22.51035 -27.22905 9.60221   1.000 42.57701  ? 29  SER A CA  1 
ATOM   243  C C   . SER A 1 29  ? 21.44606 -27.14536 8.51461   1.000 37.33073  ? 29  SER A C   1 
ATOM   244  O O   . SER A 1 29  ? 21.06791 -26.05087 8.08201   1.000 36.53218  ? 29  SER A O   1 
ATOM   245  C CB  . SER A 1 29  ? 23.84240 -27.69762 9.01857   1.000 38.66280  ? 29  SER A CB  1 
ATOM   246  O OG  . SER A 1 29  ? 24.32655 -26.78875 8.04794   1.000 43.28826  ? 29  SER A OG  1 
ATOM   247  N N   . ASP A 1 30  ? 20.94052 -28.30167 8.07102   1.000 38.24626  ? 30  ASP A N   1 
ATOM   248  C CA  . ASP A 1 30  ? 19.86207 -28.31459 7.08652   1.000 38.28873  ? 30  ASP A CA  1 
ATOM   249  C C   . ASP A 1 30  ? 18.63247 -27.57843 7.59675   1.000 39.82448  ? 30  ASP A C   1 
ATOM   250  O O   . ASP A 1 30  ? 17.92492 -26.93169 6.81592   1.000 39.30320  ? 30  ASP A O   1 
ATOM   251  C CB  . ASP A 1 30  ? 19.49317 -29.75449 6.72398   1.000 40.05336  ? 30  ASP A CB  1 
ATOM   252  C CG  . ASP A 1 30  ? 20.64084 -30.51034 6.08643   1.000 41.79368  ? 30  ASP A CG  1 
ATOM   253  O OD1 . ASP A 1 30  ? 21.66744 -29.88116 5.75540   1.000 41.33724  ? 30  ASP A OD1 1 
ATOM   254  O OD2 . ASP A 1 30  ? 20.51629 -31.73993 5.92213   1.000 40.25570  ? 30  ASP A OD2 1 
ATOM   255  N N   . LEU A 1 31  ? 18.35910 -27.66600 8.89967   1.000 42.90113  ? 31  LEU A N   1 
ATOM   256  C CA  . LEU A 1 31  ? 17.19000 -27.00802 9.46624   1.000 36.96896  ? 31  LEU A CA  1 
ATOM   257  C C   . LEU A 1 31  ? 17.41897 -25.52457 9.72697   1.000 41.85466  ? 31  LEU A C   1 
ATOM   258  O O   . LEU A 1 31  ? 16.45002 -24.75784 9.75378   1.000 44.93324  ? 31  LEU A O   1 
ATOM   259  C CB  . LEU A 1 31  ? 16.77151 -27.71744 10.75253  1.000 40.42558  ? 31  LEU A CB  1 
ATOM   260  C CG  . LEU A 1 31  ? 16.43143 -29.19462 10.54515  1.000 37.83502  ? 31  LEU A CG  1 
ATOM   261  C CD1 . LEU A 1 31  ? 16.14748 -29.88775 11.87128  1.000 42.90143  ? 31  LEU A CD1 1 
ATOM   262  C CD2 . LEU A 1 31  ? 15.25184 -29.34417 9.59564   1.000 41.15904  ? 31  LEU A CD2 1 
ATOM   263  N N   . ILE A 1 32  ? 18.67065 -25.10196 9.91691   1.000 40.89285  ? 32  ILE A N   1 
ATOM   264  C CA  . ILE A 1 32  ? 18.96700 -23.67220 9.96062   1.000 45.21384  ? 32  ILE A CA  1 
ATOM   265  C C   . ILE A 1 32  ? 18.66085 -23.02839 8.61446   1.000 44.64474  ? 32  ILE A C   1 
ATOM   266  O O   . ILE A 1 32  ? 18.09925 -21.92818 8.54719   1.000 46.81392  ? 32  ILE A O   1 
ATOM   267  C CB  . ILE A 1 32  ? 20.43172 -23.43867 10.37585  1.000 45.16894  ? 32  ILE A CB  1 
ATOM   268  C CG1 . ILE A 1 32  ? 20.66795 -23.92306 11.80560  1.000 42.28498  ? 32  ILE A CG1 1 
ATOM   269  C CG2 . ILE A 1 32  ? 20.80141 -21.96589 10.24159  1.000 43.92080  ? 32  ILE A CG2 1 
ATOM   270  C CD1 . ILE A 1 32  ? 22.10641 -23.81453 12.25648  1.000 43.62640  ? 32  ILE A CD1 1 
ATOM   271  N N   . TYR A 1 33  ? 19.01817 -23.70781 7.52194   1.000 44.89170  ? 33  TYR A N   1 
ATOM   272  C CA  . TYR A 1 33  ? 18.77804 -23.16331 6.18863   1.000 41.89010  ? 33  TYR A CA  1 
ATOM   273  C C   . TYR A 1 33  ? 17.28844 -22.96918 5.92816   1.000 46.81076  ? 33  TYR A C   1 
ATOM   274  O O   . TYR A 1 33  ? 16.86585 -21.91941 5.43009   1.000 49.20188  ? 33  TYR A O   1 
ATOM   275  C CB  . TYR A 1 33  ? 19.39356 -24.08048 5.13128   1.000 40.66724  ? 33  TYR A CB  1 
ATOM   276  C CG  . TYR A 1 33  ? 18.78769 -23.90682 3.75797   1.000 41.85030  ? 33  TYR A CG  1 
ATOM   277  C CD1 . TYR A 1 33  ? 19.14862 -22.83719 2.94854   1.000 43.16553  ? 33  TYR A CD1 1 
ATOM   278  C CD2 . TYR A 1 33  ? 17.85064 -24.81050 3.27240   1.000 40.42836  ? 33  TYR A CD2 1 
ATOM   279  C CE1 . TYR A 1 33  ? 18.59261 -22.67282 1.69420   1.000 45.40068  ? 33  TYR A CE1 1 
ATOM   280  C CE2 . TYR A 1 33  ? 17.29126 -24.65379 2.02114   1.000 43.25180  ? 33  TYR A CE2 1 
ATOM   281  C CZ  . TYR A 1 33  ? 17.66574 -23.58527 1.23769   1.000 40.92160  ? 33  TYR A CZ  1 
ATOM   282  O OH  . TYR A 1 33  ? 17.10766 -23.43016 -0.00500  1.000 42.00095  ? 33  TYR A OH  1 
ATOM   283  N N   . GLU A 1 34  ? 16.47575 -23.98055 6.24715   1.000 44.92160  ? 34  GLU A N   1 
ATOM   284  C CA  . GLU A 1 34  ? 15.03437 -23.85716 6.04732   1.000 48.40802  ? 34  GLU A CA  1 
ATOM   285  C C   . GLU A 1 34  ? 14.44933 -22.76434 6.93183   1.000 51.67065  ? 34  GLU A C   1 
ATOM   286  O O   . GLU A 1 34  ? 13.53805 -22.03817 6.51696   1.000 48.30701  ? 34  GLU A O   1 
ATOM   287  C CB  . GLU A 1 34  ? 14.34161 -25.19193 6.33069   1.000 47.01628  ? 34  GLU A CB  1 
ATOM   288  C CG  . GLU A 1 34  ? 14.97727 -26.40582 5.66508   1.000 53.53926  ? 34  GLU A CG  1 
ATOM   289  C CD  . GLU A 1 34  ? 14.69817 -26.48914 4.17388   1.000 61.26489  ? 34  GLU A CD  1 
ATOM   290  O OE1 . GLU A 1 34  ? 13.99337 -25.60769 3.63864   1.000 67.90133  ? 34  GLU A OE1 1 
ATOM   291  O OE2 . GLU A 1 34  ? 15.18468 -27.44633 3.53603   1.000 65.90500  ? 34  GLU A OE2 1 
ATOM   292  N N   . PHE A 1 35  ? 14.96539 -22.63468 8.15644   1.000 49.73837  ? 35  PHE A N   1 
ATOM   293  C CA  . PHE A 1 35  ? 14.45269 -21.63804 9.08977   1.000 45.57796  ? 35  PHE A CA  1 
ATOM   294  C C   . PHE A 1 35  ? 14.69846 -20.22441 8.57733   1.000 49.24283  ? 35  PHE A C   1 
ATOM   295  O O   . PHE A 1 35  ? 13.78323 -19.39296 8.55250   1.000 50.92005  ? 35  PHE A O   1 
ATOM   296  C CB  . PHE A 1 35  ? 15.09963 -21.84285 10.46160  1.000 52.15716  ? 35  PHE A CB  1 
ATOM   297  C CG  . PHE A 1 35  ? 14.75544 -20.78290 11.46691  1.000 45.93375  ? 35  PHE A CG  1 
ATOM   298  C CD1 . PHE A 1 35  ? 13.56268 -20.83678 12.17018  1.000 56.80877  ? 35  PHE A CD1 1 
ATOM   299  C CD2 . PHE A 1 35  ? 15.63412 -19.74326 11.72475  1.000 50.33487  ? 35  PHE A CD2 1 
ATOM   300  C CE1 . PHE A 1 35  ? 13.24640 -19.86508 13.10500  1.000 57.34736  ? 35  PHE A CE1 1 
ATOM   301  C CE2 . PHE A 1 35  ? 15.32431 -18.76839 12.65700  1.000 57.88666  ? 35  PHE A CE2 1 
ATOM   302  C CZ  . PHE A 1 35  ? 14.12891 -18.83006 13.34801  1.000 57.38880  ? 35  PHE A CZ  1 
ATOM   303  N N   . MET A 1 36  ? 15.93136 -19.93490 8.15816   1.000 51.77722  ? 36  MET A N   1 
ATOM   304  C CA  . MET A 1 36  ? 16.26525 -18.59166 7.70296   1.000 55.61266  ? 36  MET A CA  1 
ATOM   305  C C   . MET A 1 36  ? 15.64046 -18.25668 6.35591   1.000 59.22064  ? 36  MET A C   1 
ATOM   306  O O   . MET A 1 36  ? 15.44076 -17.07432 6.05917   1.000 71.76354  ? 36  MET A O   1 
ATOM   307  C CB  . MET A 1 36  ? 17.78155 -18.42707 7.62400   1.000 50.12738  ? 36  MET A CB  1 
ATOM   308  C CG  . MET A 1 36  ? 18.49599 -18.71620 8.92614   1.000 49.77608  ? 36  MET A CG  1 
ATOM   309  S SD  . MET A 1 36  ? 20.25477 -18.36064 8.82116   1.000 58.23120  ? 36  MET A SD  1 
ATOM   310  C CE  . MET A 1 36  ? 20.21300 -16.63011 8.36095   1.000 47.26737  ? 36  MET A CE  1 
ATOM   311  N N   . LYS A 1 37  ? 15.32745 -19.25518 5.53990   1.000 56.37187  ? 37  LYS A N   1 
ATOM   312  C CA  . LYS A 1 37  ? 14.75125 -19.01757 4.21575   1.000 67.94797  ? 37  LYS A CA  1 
ATOM   313  C C   . LYS A 1 37  ? 13.23269 -19.13837 4.24166   1.000 77.15574  ? 37  LYS A C   1 
ATOM   314  O O   . LYS A 1 37  ? 12.62679 -19.78327 3.38637   1.000 86.16510  ? 37  LYS A O   1 
ATOM   315  C CB  . LYS A 1 37  ? 15.35746 -19.97595 3.19888   1.000 65.32577  ? 37  LYS A CB  1 
ATOM   316  C CG  . LYS A 1 37  ? 15.50505 -19.37842 1.80918   1.000 66.67389  ? 37  LYS A CG  1 
ATOM   317  C CD  . LYS A 1 37  ? 15.99104 -20.41257 0.81266   1.000 57.19128  ? 37  LYS A CD  1 
ATOM   318  C CE  . LYS A 1 37  ? 16.50063 -19.75094 -0.45577  1.000 59.11058  ? 37  LYS A CE  1 
ATOM   319  N NZ  . LYS A 1 37  ? 17.75097 -18.98088 -0.20290  1.000 55.76367  ? 37  LYS A NZ  1 
ATOM   320  N N   . LYS A 1 38  ? 12.59869 -18.51259 5.23612   1.000 78.13781  ? 38  LYS A N   1 
ATOM   321  C CA  . LYS A 1 38  ? 11.14188 -18.53698 5.31411   1.000 92.23981  ? 38  LYS A CA  1 
ATOM   322  C C   . LYS A 1 38  ? 10.50735 -17.61871 4.27554   1.000 104.95790 ? 38  LYS A C   1 
ATOM   323  O O   . LYS A 1 38  ? 9.41188  -17.91155 3.78060   1.000 104.13362 ? 38  LYS A O   1 
ATOM   324  C CB  . LYS A 1 38  ? 10.68743 -18.14944 6.72375   1.000 85.88547  ? 38  LYS A CB  1 
ATOM   325  C CG  . LYS A 1 38  ? 9.18821  -17.92102 6.86352   1.000 94.49867  ? 38  LYS A CG  1 
ATOM   326  C CD  . LYS A 1 38  ? 8.39467  -19.15650 6.46271   1.000 96.86618  ? 38  LYS A CD  1 
ATOM   327  C CE  . LYS A 1 38  ? 7.01538  -18.77951 5.94180   1.000 98.61561  ? 38  LYS A CE  1 
ATOM   328  N NZ  . LYS A 1 38  ? 7.08492  -17.95177 4.70470   1.000 94.38698  ? 38  LYS A NZ  1 
ATOM   329  N N   . ASP A 1 39  ? 11.18300 -16.52472 3.92811   1.000 107.53211 ? 39  ASP A N   1 
ATOM   330  C CA  . ASP A 1 39  ? 10.67026 -15.51121 3.00320   1.000 107.89332 ? 39  ASP A CA  1 
ATOM   331  C C   . ASP A 1 39  ? 9.98321  -16.08807 1.76580   1.000 113.01839 ? 39  ASP A C   1 
ATOM   332  O O   . ASP A 1 39  ? 10.50974 -16.97710 1.09631   1.000 113.46415 ? 39  ASP A O   1 
ATOM   333  C CB  . ASP A 1 39  ? 11.81102 -14.59002 2.56281   1.000 110.30159 ? 39  ASP A CB  1 
ATOM   334  C CG  . ASP A 1 39  ? 13.00285 -15.35767 2.01708   1.000 106.50983 ? 39  ASP A CG  1 
ATOM   335  O OD1 . ASP A 1 39  ? 13.42193 -16.34503 2.65776   1.000 103.01871 ? 39  ASP A OD1 1 
ATOM   336  O OD2 . ASP A 1 39  ? 13.51625 -14.97912 0.94340   1.000 106.84549 ? 39  ASP A OD2 1 
ATOM   337  O OXT . ASP A 1 39  ? 8.87914  -15.67268 1.41145   1.000 116.68232 ? 39  ASP A OXT 1 
ATOM   338  N N   . ASN B 2 2   ? 44.41944 -36.86985 -30.03054 1.000 52.05517  ? 334 ASN B N   1 
ATOM   339  C CA  . ASN B 2 2   ? 44.01041 -35.96999 -28.95790 1.000 60.56038  ? 334 ASN B CA  1 
ATOM   340  C C   . ASN B 2 2   ? 42.77250 -36.48466 -28.23011 1.000 62.83179  ? 334 ASN B C   1 
ATOM   341  O O   . ASN B 2 2   ? 41.65288 -36.36145 -28.72437 1.000 67.24067  ? 334 ASN B O   1 
ATOM   342  C CB  . ASN B 2 2   ? 43.74423 -34.56834 -29.50903 1.000 64.14104  ? 334 ASN B CB  1 
ATOM   343  C CG  . ASN B 2 2   ? 44.99969 -33.72584 -29.58905 1.000 70.81832  ? 334 ASN B CG  1 
ATOM   344  O OD1 . ASN B 2 2   ? 46.10922 -34.22338 -29.39504 1.000 70.48621  ? 334 ASN B OD1 1 
ATOM   345  N ND2 . ASN B 2 2   ? 44.83104 -32.43957 -29.87564 1.000 67.69400  ? 334 ASN B ND2 1 
ATOM   346  N N   . LEU B 2 3   ? 42.97989 -37.05893 -27.05166 1.000 57.96440  ? 335 LEU B N   1 
ATOM   347  C CA  . LEU B 2 3   ? 41.89474 -37.57200 -26.23050 1.000 60.72904  ? 335 LEU B CA  1 
ATOM   348  C C   . LEU B 2 3   ? 41.60972 -36.61348 -25.08121 1.000 59.15389  ? 335 LEU B C   1 
ATOM   349  O O   . LEU B 2 3   ? 42.50831 -35.93620 -24.57570 1.000 60.17461  ? 335 LEU B O   1 
ATOM   350  C CB  . LEU B 2 3   ? 42.22843 -38.96281 -25.68279 1.000 57.68974  ? 335 LEU B CB  1 
ATOM   351  C CG  . LEU B 2 3   ? 41.84572 -40.17229 -26.54304 1.000 61.37746  ? 335 LEU B CG  1 
ATOM   352  C CD1 . LEU B 2 3   ? 42.45324 -40.09354 -27.93806 1.000 67.46263  ? 335 LEU B CD1 1 
ATOM   353  C CD2 . LEU B 2 3   ? 42.25578 -41.46478 -25.85249 1.000 55.80487  ? 335 LEU B CD2 1 
ATOM   354  N N   . CYS B 2 4   ? 40.34656 -36.55754 -24.67866 1.000 59.19940  ? 336 CYS B N   1 
ATOM   355  C CA  . CYS B 2 4   ? 39.95498 -35.66676 -23.59338 1.000 60.30303  ? 336 CYS B CA  1 
ATOM   356  C C   . CYS B 2 4   ? 40.43196 -36.23334 -22.26138 1.000 50.58216  ? 336 CYS B C   1 
ATOM   357  O O   . CYS B 2 4   ? 40.20232 -37.41476 -21.97760 1.000 52.51698  ? 336 CYS B O   1 
ATOM   358  C CB  . CYS B 2 4   ? 38.44153 -35.46489 -23.58361 1.000 53.52245  ? 336 CYS B CB  1 
ATOM   359  S SG  . CYS B 2 4   ? 37.79011 -34.69526 -25.09601 1.000 53.29747  ? 336 CYS B SG  1 
ATOM   360  N N   . PRO B 2 5   ? 41.09516 -35.43518 -21.42592 1.000 51.85563  ? 337 PRO B N   1 
ATOM   361  C CA  . PRO B 2 5   ? 41.68010 -35.94936 -20.17054 1.000 59.26320  ? 337 PRO B CA  1 
ATOM   362  C C   . PRO B 2 5   ? 40.67408 -35.96869 -19.02441 1.000 56.98402  ? 337 PRO B C   1 
ATOM   363  O O   . PRO B 2 5   ? 40.71453 -35.16093 -18.08661 1.000 60.29680  ? 337 PRO B O   1 
ATOM   364  C CB  . PRO B 2 5   ? 42.83701 -34.97509 -19.92830 1.000 65.34054  ? 337 PRO B CB  1 
ATOM   365  C CG  . PRO B 2 5   ? 42.45101 -33.69472 -20.66466 1.000 59.64933  ? 337 PRO B CG  1 
ATOM   366  C CD  . PRO B 2 5   ? 41.25763 -33.97803 -21.54392 1.000 60.51497  ? 337 PRO B CD  1 
ATOM   367  N N   . PHE B 2 6   ? 39.73884 -36.91668 -19.09644 1.000 57.98596  ? 338 PHE B N   1 
ATOM   368  C CA  . PHE B 2 6   ? 38.75578 -37.08673 -18.03591 1.000 57.24387  ? 338 PHE B CA  1 
ATOM   369  C C   . PHE B 2 6   ? 39.34146 -37.75711 -16.80214 1.000 62.05090  ? 338 PHE B C   1 
ATOM   370  O O   . PHE B 2 6   ? 38.71926 -37.71303 -15.73551 1.000 62.74148  ? 338 PHE B O   1 
ATOM   371  C CB  . PHE B 2 6   ? 37.56018 -37.89134 -18.54922 1.000 58.98450  ? 338 PHE B CB  1 
ATOM   372  C CG  . PHE B 2 6   ? 36.63514 -37.10092 -19.42697 1.000 58.97255  ? 338 PHE B CG  1 
ATOM   373  C CD1 . PHE B 2 6   ? 36.38512 -35.76412 -19.16340 1.000 52.53663  ? 338 PHE B CD1 1 
ATOM   374  C CD2 . PHE B 2 6   ? 36.02135 -37.69004 -20.51848 1.000 60.14138  ? 338 PHE B CD2 1 
ATOM   375  C CE1 . PHE B 2 6   ? 35.53359 -35.03104 -19.96845 1.000 56.32231  ? 338 PHE B CE1 1 
ATOM   376  C CE2 . PHE B 2 6   ? 35.16937 -36.96222 -21.32775 1.000 62.30241  ? 338 PHE B CE2 1 
ATOM   377  C CZ  . PHE B 2 6   ? 34.92650 -35.63019 -21.05347 1.000 53.97790  ? 338 PHE B CZ  1 
ATOM   378  N N   . GLY B 2 7   ? 40.51555 -38.38118 -16.92348 1.000 68.47555  ? 339 GLY B N   1 
ATOM   379  C CA  . GLY B 2 7   ? 41.17057 -38.93971 -15.75427 1.000 60.65289  ? 339 GLY B CA  1 
ATOM   380  C C   . GLY B 2 7   ? 41.68868 -37.87835 -14.80675 1.000 63.46294  ? 339 GLY B C   1 
ATOM   381  O O   . GLY B 2 7   ? 41.80977 -38.12150 -13.60265 1.000 65.41054  ? 339 GLY B O   1 
ATOM   382  N N   . GLU B 2 8   ? 42.00119 -36.69055 -15.33018 1.000 65.14846  ? 340 GLU B N   1 
ATOM   383  C CA  . GLU B 2 8   ? 42.41678 -35.58977 -14.46914 1.000 63.33216  ? 340 GLU B CA  1 
ATOM   384  C C   . GLU B 2 8   ? 41.26480 -35.09272 -13.60431 1.000 59.65560  ? 340 GLU B C   1 
ATOM   385  O O   . GLU B 2 8   ? 41.49504 -34.56603 -12.51017 1.000 60.74968  ? 340 GLU B O   1 
ATOM   386  C CB  . GLU B 2 8   ? 42.98406 -34.44968 -15.31699 1.000 62.83065  ? 340 GLU B CB  1 
ATOM   387  C CG  . GLU B 2 8   ? 43.46917 -33.24907 -14.51777 1.000 73.13672  ? 340 GLU B CG  1 
ATOM   388  C CD  . GLU B 2 8   ? 43.98693 -32.13160 -15.40147 1.000 73.27277  ? 340 GLU B CD  1 
ATOM   389  O OE1 . GLU B 2 8   ? 44.30652 -32.40394 -16.57737 1.000 72.85969  ? 340 GLU B OE1 1 
ATOM   390  O OE2 . GLU B 2 8   ? 44.07034 -30.98089 -14.92205 1.000 69.71788  ? 340 GLU B OE2 1 
ATOM   391  N N   . VAL B 2 9   ? 40.02871 -35.25977 -14.06531 1.000 54.83215  ? 341 VAL B N   1 
ATOM   392  C CA  . VAL B 2 9   ? 38.86345 -34.80215 -13.31496 1.000 55.15141  ? 341 VAL B CA  1 
ATOM   393  C C   . VAL B 2 9   ? 38.29070 -35.91309 -12.44479 1.000 59.33942  ? 341 VAL B C   1 
ATOM   394  O O   . VAL B 2 9   ? 38.10684 -35.73730 -11.23738 1.000 57.65197  ? 341 VAL B O   1 
ATOM   395  C CB  . VAL B 2 9   ? 37.80001 -34.23941 -14.28143 1.000 52.39115  ? 341 VAL B CB  1 
ATOM   396  C CG1 . VAL B 2 9   ? 36.58114 -33.75826 -13.50906 1.000 48.48869  ? 341 VAL B CG1 1 
ATOM   397  C CG2 . VAL B 2 9   ? 38.38693 -33.11320 -15.11340 1.000 55.35933  ? 341 VAL B CG2 1 
ATOM   398  N N   . PHE B 2 10  ? 38.00287 -37.07371 -13.03718 1.000 56.81627  ? 342 PHE B N   1 
ATOM   399  C CA  . PHE B 2 10  ? 37.39003 -38.16153 -12.27975 1.000 56.11218  ? 342 PHE B CA  1 
ATOM   400  C C   . PHE B 2 10  ? 38.40364 -38.83893 -11.36480 1.000 58.87994  ? 342 PHE B C   1 
ATOM   401  O O   . PHE B 2 10  ? 38.20331 -38.92125 -10.14752 1.000 63.65288  ? 342 PHE B O   1 
ATOM   402  C CB  . PHE B 2 10  ? 36.75884 -39.17540 -13.23483 1.000 53.94199  ? 342 PHE B CB  1 
ATOM   403  C CG  . PHE B 2 10  ? 35.50428 -38.68338 -13.89613 1.000 51.00612  ? 342 PHE B CG  1 
ATOM   404  C CD1 . PHE B 2 10  ? 35.56590 -37.93039 -15.05822 1.000 54.84001  ? 342 PHE B CD1 1 
ATOM   405  C CD2 . PHE B 2 10  ? 34.26297 -38.97323 -13.35507 1.000 46.80982  ? 342 PHE B CD2 1 
ATOM   406  C CE1 . PHE B 2 10  ? 34.41291 -37.47578 -15.66890 1.000 50.52917  ? 342 PHE B CE1 1 
ATOM   407  C CE2 . PHE B 2 10  ? 33.10639 -38.52160 -13.95903 1.000 51.68146  ? 342 PHE B CE2 1 
ATOM   408  C CZ  . PHE B 2 10  ? 33.18093 -37.77277 -15.11897 1.000 49.37866  ? 342 PHE B CZ  1 
ATOM   409  N N   . ASN B 2 11  ? 39.50315 -39.33342 -11.93404 1.000 70.23603  ? 343 ASN B N   1 
ATOM   410  C CA  . ASN B 2 11  ? 40.52717 -40.03296 -11.16769 1.000 66.51488  ? 343 ASN B CA  1 
ATOM   411  C C   . ASN B 2 11  ? 41.44115 -39.08890 -10.38638 1.000 66.79115  ? 343 ASN B C   1 
ATOM   412  O O   . ASN B 2 11  ? 42.53484 -39.50069 -9.98137  1.000 74.54563  ? 343 ASN B O   1 
ATOM   413  C CB  . ASN B 2 11  ? 41.35593 -40.93191 -12.09281 1.000 73.99343  ? 343 ASN B CB  1 
ATOM   414  C CG  . ASN B 2 11  ? 40.69606 -42.28038 -12.34058 1.000 79.02641  ? 343 ASN B CG  1 
ATOM   415  O OD1 . ASN B 2 11  ? 39.96186 -42.78320 -11.48971 1.000 81.14848  ? 343 ASN B OD1 1 
ATOM   416  N ND2 . ASN B 2 11  ? 40.95597 -42.87345 -13.50594 1.000 80.02874  ? 343 ASN B ND2 1 
ATOM   417  N N   . ALA B 2 12  ? 41.02396 -37.84534 -10.16276 1.000 63.42127  ? 344 ALA B N   1 
ATOM   418  C CA  . ALA B 2 12  ? 41.80291 -36.93115 -9.34172  1.000 60.13249  ? 344 ALA B CA  1 
ATOM   419  C C   . ALA B 2 12  ? 41.76452 -37.36067 -7.88011  1.000 61.85103  ? 344 ALA B C   1 
ATOM   420  O O   . ALA B 2 12  ? 40.79339 -37.95769 -7.40780  1.000 64.43649  ? 344 ALA B O   1 
ATOM   421  C CB  . ALA B 2 12  ? 41.27625 -35.50346 -9.47590  1.000 53.53856  ? 344 ALA B CB  1 
ATOM   422  N N   . THR B 2 13  ? 42.84118 -37.04536 -7.16007  1.000 60.72321  ? 345 THR B N   1 
ATOM   423  C CA  . THR B 2 13  ? 42.93112 -37.41528 -5.75193  1.000 63.76504  ? 345 THR B CA  1 
ATOM   424  C C   . THR B 2 13  ? 42.24176 -36.38742 -4.86186  1.000 60.22540  ? 345 THR B C   1 
ATOM   425  O O   . THR B 2 13  ? 41.41710 -36.74293 -4.01306  1.000 52.26452  ? 345 THR B O   1 
ATOM   426  C CB  . THR B 2 13  ? 44.39672 -37.57680 -5.34394  1.000 62.87947  ? 345 THR B CB  1 
ATOM   427  O OG1 . THR B 2 13  ? 44.99905 -38.61720 -6.12372  1.000 68.81927  ? 345 THR B OG1 1 
ATOM   428  C CG2 . THR B 2 13  ? 44.50391 -37.92771 -3.86619  1.000 67.37767  ? 345 THR B CG2 1 
ATOM   429  N N   . ARG B 2 14  ? 42.56481 -35.11093 -5.04616  1.000 61.89944  ? 346 ARG B N   1 
ATOM   430  C CA  . ARG B 2 14  ? 42.01188 -34.03064 -4.24091  1.000 59.85097  ? 346 ARG B CA  1 
ATOM   431  C C   . ARG B 2 14  ? 40.85400 -33.37761 -4.98659  1.000 54.32491  ? 346 ARG B C   1 
ATOM   432  O O   . ARG B 2 14  ? 41.04771 -32.80880 -6.06561  1.000 57.73817  ? 346 ARG B O   1 
ATOM   433  C CB  . ARG B 2 14  ? 43.08492 -32.99133 -3.91508  1.000 62.99838  ? 346 ARG B CB  1 
ATOM   434  C CG  . ARG B 2 14  ? 43.46504 -32.91907 -2.44456  1.000 73.46721  ? 346 ARG B CG  1 
ATOM   435  C CD  . ARG B 2 14  ? 44.01856 -31.54485 -2.09363  1.000 77.22457  ? 346 ARG B CD  1 
ATOM   436  N NE  . ARG B 2 14  ? 43.06241 -30.48816 -2.40628  1.000 74.28655  ? 346 ARG B NE  1 
ATOM   437  C CZ  . ARG B 2 14  ? 43.26397 -29.19780 -2.17614  1.000 69.31402  ? 346 ARG B CZ  1 
ATOM   438  N NH1 . ARG B 2 14  ? 44.38422 -28.76054 -1.62451  1.000 72.94656  ? 346 ARG B NH1 1 
ATOM   439  N NH2 . ARG B 2 14  ? 42.31716 -28.32412 -2.50776  1.000 61.97749  ? 346 ARG B NH2 1 
ATOM   440  N N   . PHE B 2 15  ? 39.66036 -33.45688 -4.41084  1.000 50.81045  ? 347 PHE B N   1 
ATOM   441  C CA  . PHE B 2 15  ? 38.49525 -32.74603 -4.91313  1.000 44.67543  ? 347 PHE B CA  1 
ATOM   442  C C   . PHE B 2 15  ? 38.29407 -31.45164 -4.13230  1.000 47.35850  ? 347 PHE B C   1 
ATOM   443  O O   . PHE B 2 15  ? 38.79205 -31.28417 -3.01557  1.000 44.53229  ? 347 PHE B O   1 
ATOM   444  C CB  . PHE B 2 15  ? 37.24062 -33.62033 -4.82348  1.000 44.02332  ? 347 PHE B CB  1 
ATOM   445  C CG  . PHE B 2 15  ? 36.97150 -34.42728 -6.06495  1.000 47.32504  ? 347 PHE B CG  1 
ATOM   446  C CD1 . PHE B 2 15  ? 37.84003 -35.43262 -6.45866  1.000 46.15858  ? 347 PHE B CD1 1 
ATOM   447  C CD2 . PHE B 2 15  ? 35.84394 -34.18452 -6.83298  1.000 44.74783  ? 347 PHE B CD2 1 
ATOM   448  C CE1 . PHE B 2 15  ? 37.59349 -36.17448 -7.60100  1.000 51.39157  ? 347 PHE B CE1 1 
ATOM   449  C CE2 . PHE B 2 15  ? 35.59078 -34.92397 -7.97462  1.000 45.18190  ? 347 PHE B CE2 1 
ATOM   450  C CZ  . PHE B 2 15  ? 36.46703 -35.91955 -8.35944  1.000 48.50413  ? 347 PHE B CZ  1 
ATOM   451  N N   . ALA B 2 16  ? 37.55560 -30.53062 -4.73818  1.000 41.71533  ? 348 ALA B N   1 
ATOM   452  C CA  . ALA B 2 16  ? 37.31269 -29.23416 -4.12842  1.000 42.44748  ? 348 ALA B CA  1 
ATOM   453  C C   . ALA B 2 16  ? 36.03819 -29.25908 -3.29004  1.000 44.65247  ? 348 ALA B C   1 
ATOM   454  O O   . ALA B 2 16  ? 35.19119 -30.14601 -3.42278  1.000 44.87243  ? 348 ALA B O   1 
ATOM   455  C CB  . ALA B 2 16  ? 37.21535 -28.14590 -5.19851  1.000 35.40562  ? 348 ALA B CB  1 
ATOM   456  N N   . SER B 2 17  ? 35.91899 -28.27089 -2.40718  1.000 37.94729  ? 349 SER B N   1 
ATOM   457  C CA  . SER B 2 17  ? 34.66837 -28.05825 -1.69613  1.000 41.56731  ? 349 SER B CA  1 
ATOM   458  C C   . SER B 2 17  ? 33.63700 -27.44811 -2.63648  1.000 35.48439  ? 349 SER B C   1 
ATOM   459  O O   . SER B 2 17  ? 33.97644 -26.75159 -3.59516  1.000 45.73452  ? 349 SER B O   1 
ATOM   460  C CB  . SER B 2 17  ? 34.88168 -27.15364 -0.48184  1.000 40.23396  ? 349 SER B CB  1 
ATOM   461  O OG  . SER B 2 17  ? 35.74523 -27.76646 0.45779   1.000 38.92871  ? 349 SER B OG  1 
ATOM   462  N N   . VAL B 2 18  ? 32.36205 -27.71802 -2.35295  1.000 34.97904  ? 350 VAL B N   1 
ATOM   463  C CA  . VAL B 2 18  ? 31.30572 -27.36242 -3.29545  1.000 36.75769  ? 350 VAL B CA  1 
ATOM   464  C C   . VAL B 2 18  ? 31.19657 -25.84909 -3.45258  1.000 38.34390  ? 350 VAL B C   1 
ATOM   465  O O   . VAL B 2 18  ? 30.92514 -25.34840 -4.55006  1.000 41.10728  ? 350 VAL B O   1 
ATOM   466  C CB  . VAL B 2 18  ? 29.96812 -27.99492 -2.86645  1.000 40.16825  ? 350 VAL B CB  1 
ATOM   467  C CG1 . VAL B 2 18  ? 29.56381 -27.53451 -1.46790  1.000 35.62257  ? 350 VAL B CG1 1 
ATOM   468  C CG2 . VAL B 2 18  ? 28.87738 -27.68053 -3.88324  1.000 32.71446  ? 350 VAL B CG2 1 
ATOM   469  N N   . TYR B 2 19  ? 31.41359 -25.09404 -2.37314  1.000 37.97756  ? 351 TYR B N   1 
ATOM   470  C CA  . TYR B 2 19  ? 31.30725 -23.64247 -2.47767  1.000 39.53995  ? 351 TYR B CA  1 
ATOM   471  C C   . TYR B 2 19  ? 32.42319 -23.06676 -3.34012  1.000 39.04153  ? 351 TYR B C   1 
ATOM   472  O O   . TYR B 2 19  ? 32.22233 -22.05317 -4.01823  1.000 35.35711  ? 351 TYR B O   1 
ATOM   473  C CB  . TYR B 2 19  ? 31.31491 -23.00631 -1.08472  1.000 37.54848  ? 351 TYR B CB  1 
ATOM   474  C CG  . TYR B 2 19  ? 32.69390 -22.70180 -0.54924  1.000 36.10053  ? 351 TYR B CG  1 
ATOM   475  C CD1 . TYR B 2 19  ? 33.47602 -23.69797 0.01454   1.000 37.28770  ? 351 TYR B CD1 1 
ATOM   476  C CD2 . TYR B 2 19  ? 33.21220 -21.41487 -0.60597  1.000 40.08912  ? 351 TYR B CD2 1 
ATOM   477  C CE1 . TYR B 2 19  ? 34.73770 -23.42340 0.50226   1.000 39.47459  ? 351 TYR B CE1 1 
ATOM   478  C CE2 . TYR B 2 19  ? 34.47277 -21.13122 -0.12255  1.000 36.82779  ? 351 TYR B CE2 1 
ATOM   479  C CZ  . TYR B 2 19  ? 35.23190 -22.13889 0.42802   1.000 42.79555  ? 351 TYR B CZ  1 
ATOM   480  O OH  . TYR B 2 19  ? 36.48707 -21.85752 0.91644   1.000 49.25346  ? 351 TYR B OH  1 
ATOM   481  N N   . ALA B 2 20  ? 33.59787 -23.69529 -3.32670  1.000 40.38458  ? 352 ALA B N   1 
ATOM   482  C CA  . ALA B 2 20  ? 34.68689 -23.31597 -4.21543  1.000 40.06171  ? 352 ALA B CA  1 
ATOM   483  C C   . ALA B 2 20  ? 34.90117 -24.40703 -5.25575  1.000 39.15397  ? 352 ALA B C   1 
ATOM   484  O O   . ALA B 2 20  ? 36.01517 -24.91974 -5.40844  1.000 37.47411  ? 352 ALA B O   1 
ATOM   485  C CB  . ALA B 2 20  ? 35.97127 -23.06656 -3.42462  1.000 41.02960  ? 352 ALA B CB  1 
ATOM   486  N N   . TRP B 2 21  ? 33.83428 -24.77241 -5.96359  1.000 42.68245  ? 353 TRP B N   1 
ATOM   487  C CA  . TRP B 2 21  ? 33.90288 -25.87061 -6.91685  1.000 42.21312  ? 353 TRP B CA  1 
ATOM   488  C C   . TRP B 2 21  ? 34.95841 -25.60012 -7.98018  1.000 40.63636  ? 353 TRP B C   1 
ATOM   489  O O   . TRP B 2 21  ? 35.20964 -24.45648 -8.36579  1.000 38.18897  ? 353 TRP B O   1 
ATOM   490  C CB  . TRP B 2 21  ? 32.53712 -26.10663 -7.56770  1.000 35.88109  ? 353 TRP B CB  1 
ATOM   491  C CG  . TRP B 2 21  ? 31.82078 -24.86371 -8.02167  1.000 37.71087  ? 353 TRP B CG  1 
ATOM   492  C CD1 . TRP B 2 21  ? 31.07102 -24.02220 -7.25210  1.000 37.40484  ? 353 TRP B CD1 1 
ATOM   493  C CD2 . TRP B 2 21  ? 31.76167 -24.34218 -9.35788  1.000 43.33880  ? 353 TRP B CD2 1 
ATOM   494  N NE1 . TRP B 2 21  ? 30.55954 -23.00443 -8.01967  1.000 42.60131  ? 353 TRP B NE1 1 
ATOM   495  C CE2 . TRP B 2 21  ? 30.96847 -23.17730 -9.31659  1.000 40.92368  ? 353 TRP B CE2 1 
ATOM   496  C CE3 . TRP B 2 21  ? 32.30766 -24.74359 -10.58176 1.000 38.99231  ? 353 TRP B CE3 1 
ATOM   497  C CZ2 . TRP B 2 21  ? 30.70875 -22.40962 -10.45022 1.000 37.92079  ? 353 TRP B CZ2 1 
ATOM   498  C CZ3 . TRP B 2 21  ? 32.04777 -23.97852 -11.70791 1.000 45.03525  ? 353 TRP B CZ3 1 
ATOM   499  C CH2 . TRP B 2 21  ? 31.25542 -22.82547 -11.63359 1.000 43.00814  ? 353 TRP B CH2 1 
ATOM   500  N N   . ASN B 2 22  ? 35.59448 -26.67219 -8.43647  1.000 40.08734  ? 354 ASN B N   1 
ATOM   501  C CA  . ASN B 2 22  ? 36.66513 -26.59027 -9.41744  1.000 46.16916  ? 354 ASN B CA  1 
ATOM   502  C C   . ASN B 2 22  ? 36.09529 -26.80576 -10.81432 1.000 44.65439  ? 354 ASN B C   1 
ATOM   503  O O   . ASN B 2 22  ? 35.28595 -27.71472 -11.02706 1.000 46.90904  ? 354 ASN B O   1 
ATOM   504  C CB  . ASN B 2 22  ? 37.74888 -27.62490 -9.11302  1.000 45.81950  ? 354 ASN B CB  1 
ATOM   505  C CG  . ASN B 2 22  ? 38.93265 -27.52124 -10.04981 1.000 51.42844  ? 354 ASN B CG  1 
ATOM   506  O OD1 . ASN B 2 22  ? 39.01318 -28.23835 -11.04693 1.000 56.75377  ? 354 ASN B OD1 1 
ATOM   507  N ND2 . ASN B 2 22  ? 39.85831 -26.62074 -9.73755  1.000 53.39796  ? 354 ASN B ND2 1 
ATOM   508  N N   . ARG B 2 23  ? 36.51216 -25.96682 -11.75854 1.000 46.97510  ? 355 ARG B N   1 
ATOM   509  C CA  . ARG B 2 23  ? 36.07838 -26.05973 -13.14688 1.000 44.99235  ? 355 ARG B CA  1 
ATOM   510  C C   . ARG B 2 23  ? 37.27447 -26.35968 -14.03566 1.000 42.03719  ? 355 ARG B C   1 
ATOM   511  O O   . ARG B 2 23  ? 38.28866 -25.65737 -13.97809 1.000 44.58102  ? 355 ARG B O   1 
ATOM   512  C CB  . ARG B 2 23  ? 35.39557 -24.77057 -13.60674 1.000 37.49553  ? 355 ARG B CB  1 
ATOM   513  C CG  . ARG B 2 23  ? 35.30233 -24.63927 -15.11527 1.000 42.06581  ? 355 ARG B CG  1 
ATOM   514  C CD  . ARG B 2 23  ? 34.25265 -23.62437 -15.51809 1.000 41.12938  ? 355 ARG B CD  1 
ATOM   515  N NE  . ARG B 2 23  ? 32.90374 -24.14278 -15.33027 1.000 37.55332  ? 355 ARG B NE  1 
ATOM   516  C CZ  . ARG B 2 23  ? 31.79840 -23.48590 -15.65245 1.000 40.85125  ? 355 ARG B CZ  1 
ATOM   517  N NH1 . ARG B 2 23  ? 31.84325 -22.26602 -16.16215 1.000 36.70060  ? 355 ARG B NH1 1 
ATOM   518  N NH2 . ARG B 2 23  ? 30.61828 -24.06918 -15.46204 1.000 40.82613  ? 355 ARG B NH2 1 
ATOM   519  N N   . LYS B 2 24  ? 37.15061 -27.40126 -14.85201 1.000 46.30902  ? 356 LYS B N   1 
ATOM   520  C CA  . LYS B 2 24  ? 38.17228 -27.78861 -15.81471 1.000 46.60506  ? 356 LYS B CA  1 
ATOM   521  C C   . LYS B 2 24  ? 37.60543 -27.64705 -17.22044 1.000 45.26586  ? 356 LYS B C   1 
ATOM   522  O O   . LYS B 2 24  ? 36.50574 -28.13574 -17.50239 1.000 39.96993  ? 356 LYS B O   1 
ATOM   523  C CB  . LYS B 2 24  ? 38.64093 -29.22602 -15.56465 1.000 47.87519  ? 356 LYS B CB  1 
ATOM   524  C CG  . LYS B 2 24  ? 39.51583 -29.81124 -16.66311 1.000 52.20795  ? 356 LYS B CG  1 
ATOM   525  C CD  . LYS B 2 24  ? 40.89217 -29.17300 -16.69138 1.000 59.58216  ? 356 LYS B CD  1 
ATOM   526  C CE  . LYS B 2 24  ? 41.76057 -29.79988 -17.77102 1.000 68.27214  ? 356 LYS B CE  1 
ATOM   527  N NZ  . LYS B 2 24  ? 41.86303 -31.27866 -17.61177 1.000 69.97724  ? 356 LYS B NZ  1 
ATOM   528  N N   . ARG B 2 25  ? 38.34747 -26.97138 -18.09382 1.000 49.94213  ? 357 ARG B N   1 
ATOM   529  C CA  . ARG B 2 25  ? 37.93715 -26.80287 -19.48069 1.000 47.13753  ? 357 ARG B CA  1 
ATOM   530  C C   . ARG B 2 25  ? 38.42604 -27.98624 -20.30421 1.000 44.92643  ? 357 ARG B C   1 
ATOM   531  O O   . ARG B 2 25  ? 39.59488 -28.37533 -20.21190 1.000 46.17398  ? 357 ARG B O   1 
ATOM   532  C CB  . ARG B 2 25  ? 38.47860 -25.49608 -20.06192 1.000 41.97126  ? 357 ARG B CB  1 
ATOM   533  C CG  . ARG B 2 25  ? 38.03393 -25.24049 -21.49718 1.000 46.17652  ? 357 ARG B CG  1 
ATOM   534  C CD  . ARG B 2 25  ? 38.76636 -24.06309 -22.12396 1.000 46.26464  ? 357 ARG B CD  1 
ATOM   535  N NE  . ARG B 2 25  ? 38.38719 -22.78394 -21.53564 1.000 49.59359  ? 357 ARG B NE  1 
ATOM   536  C CZ  . ARG B 2 25  ? 37.36356 -22.04546 -21.94277 1.000 49.47583  ? 357 ARG B CZ  1 
ATOM   537  N NH1 . ARG B 2 25  ? 36.57073 -22.44349 -22.92451 1.000 55.26083  ? 357 ARG B NH1 1 
ATOM   538  N NH2 . ARG B 2 25  ? 37.12958 -20.87810 -21.35079 1.000 48.80613  ? 357 ARG B NH2 1 
ATOM   539  N N   . ILE B 2 26  ? 37.52571 -28.55960 -21.09747 1.000 45.35893  ? 358 ILE B N   1 
ATOM   540  C CA  . ILE B 2 26  ? 37.84197 -29.65715 -22.00410 1.000 46.47513  ? 358 ILE B CA  1 
ATOM   541  C C   . ILE B 2 26  ? 37.61641 -29.15478 -23.42244 1.000 45.97381  ? 358 ILE B C   1 
ATOM   542  O O   . ILE B 2 26  ? 36.50013 -28.75245 -23.77444 1.000 48.55314  ? 358 ILE B O   1 
ATOM   543  C CB  . ILE B 2 26  ? 36.99517 -30.90794 -21.71328 1.000 49.66177  ? 358 ILE B CB  1 
ATOM   544  C CG1 . ILE B 2 26  ? 37.61564 -31.73458 -20.58386 1.000 49.49814  ? 358 ILE B CG1 1 
ATOM   545  C CG2 . ILE B 2 26  ? 36.85033 -31.76649 -22.95163 1.000 43.10275  ? 358 ILE B CG2 1 
ATOM   546  C CD1 . ILE B 2 26  ? 37.36384 -31.18636 -19.20923 1.000 50.63778  ? 358 ILE B CD1 1 
ATOM   547  N N   . SER B 2 27  ? 38.67473 -29.15955 -24.22809 1.000 44.89233  ? 359 SER B N   1 
ATOM   548  C CA  . SER B 2 27  ? 38.58691 -28.63096 -25.58067 1.000 52.71905  ? 359 SER B CA  1 
ATOM   549  C C   . SER B 2 27  ? 39.65359 -29.28430 -26.44440 1.000 54.49455  ? 359 SER B C   1 
ATOM   550  O O   . SER B 2 27  ? 40.69811 -29.71196 -25.94546 1.000 53.90935  ? 359 SER B O   1 
ATOM   551  C CB  . SER B 2 27  ? 38.74665 -27.10679 -25.59698 1.000 54.94475  ? 359 SER B CB  1 
ATOM   552  O OG  . SER B 2 27  ? 40.01515 -26.72419 -25.09584 1.000 59.02458  ? 359 SER B OG  1 
ATOM   553  N N   . ASN B 2 28  ? 39.36976 -29.35516 -27.74656 1.000 55.62724  ? 360 ASN B N   1 
ATOM   554  C CA  . ASN B 2 28  ? 40.29822 -29.88612 -28.74463 1.000 52.95533  ? 360 ASN B CA  1 
ATOM   555  C C   . ASN B 2 28  ? 40.72541 -31.31159 -28.39437 1.000 53.22195  ? 360 ASN B C   1 
ATOM   556  O O   . ASN B 2 28  ? 41.90340 -31.60138 -28.17097 1.000 55.65156  ? 360 ASN B O   1 
ATOM   557  C CB  . ASN B 2 28  ? 41.51744 -28.97051 -28.90034 1.000 55.44755  ? 360 ASN B CB  1 
ATOM   558  C CG  . ASN B 2 28  ? 41.13621 -27.54190 -29.22789 1.000 59.79392  ? 360 ASN B CG  1 
ATOM   559  O OD1 . ASN B 2 28  ? 40.74322 -27.23572 -30.35380 1.000 64.69691  ? 360 ASN B OD1 1 
ATOM   560  N ND2 . ASN B 2 28  ? 41.25960 -26.65512 -28.24518 1.000 59.38238  ? 360 ASN B ND2 1 
ATOM   561  N N   . CYS B 2 29  ? 39.74172 -32.20562 -28.35898 1.000 48.17196  ? 361 CYS B N   1 
ATOM   562  C CA  . CYS B 2 29  ? 39.99734 -33.58298 -27.95974 1.000 45.88452  ? 361 CYS B CA  1 
ATOM   563  C C   . CYS B 2 29  ? 38.78908 -34.43710 -28.31661 1.000 45.32222  ? 361 CYS B C   1 
ATOM   564  O O   . CYS B 2 29  ? 37.70536 -33.92740 -28.61349 1.000 43.93267  ? 361 CYS B O   1 
ATOM   565  C CB  . CYS B 2 29  ? 40.30577 -33.67438 -26.46422 1.000 57.94161  ? 361 CYS B CB  1 
ATOM   566  S SG  . CYS B 2 29  ? 38.97791 -33.07176 -25.39047 1.000 51.32446  ? 361 CYS B SG  1 
ATOM   567  N N   . VAL B 2 30  ? 38.99603 -35.75173 -28.27650 1.000 50.83459  ? 362 VAL B N   1 
ATOM   568  C CA  . VAL B 2 30  ? 37.94996 -36.74271 -28.50046 1.000 51.69253  ? 362 VAL B CA  1 
ATOM   569  C C   . VAL B 2 30  ? 37.65308 -37.43193 -27.17535 1.000 51.04281  ? 362 VAL B C   1 
ATOM   570  O O   . VAL B 2 30  ? 38.57384 -37.80528 -26.43907 1.000 50.35441  ? 362 VAL B O   1 
ATOM   571  C CB  . VAL B 2 30  ? 38.36640 -37.76703 -29.57497 1.000 45.18687  ? 362 VAL B CB  1 
ATOM   572  C CG1 . VAL B 2 30  ? 37.25785 -38.78037 -29.81203 1.000 42.95031  ? 362 VAL B CG1 1 
ATOM   573  C CG2 . VAL B 2 30  ? 38.73213 -37.05634 -30.86578 1.000 57.72350  ? 362 VAL B CG2 1 
ATOM   574  N N   . ALA B 2 31  ? 36.36790 -37.60130 -26.87293 1.000 49.81882  ? 363 ALA B N   1 
ATOM   575  C CA  . ALA B 2 31  ? 35.92468 -38.15613 -25.60026 1.000 57.61808  ? 363 ALA B CA  1 
ATOM   576  C C   . ALA B 2 31  ? 35.11124 -39.41714 -25.84745 1.000 56.06701  ? 363 ALA B C   1 
ATOM   577  O O   . ALA B 2 31  ? 34.09747 -39.37865 -26.55296 1.000 58.05605  ? 363 ALA B O   1 
ATOM   578  C CB  . ALA B 2 31  ? 35.09857 -37.13495 -24.81647 1.000 59.24204  ? 363 ALA B CB  1 
ATOM   579  N N   . ASP B 2 32  ? 35.55346 -40.52876 -25.26269 1.000 59.47853  ? 364 ASP B N   1 
ATOM   580  C CA  . ASP B 2 32  ? 34.78905 -41.77472 -25.27159 1.000 56.93262  ? 364 ASP B CA  1 
ATOM   581  C C   . ASP B 2 32  ? 33.97302 -41.81384 -23.98688 1.000 61.07158  ? 364 ASP B C   1 
ATOM   582  O O   . ASP B 2 32  ? 34.44462 -42.24816 -22.93506 1.000 58.78656  ? 364 ASP B O   1 
ATOM   583  C CB  . ASP B 2 32  ? 35.71156 -42.98042 -25.39580 1.000 53.73892  ? 364 ASP B CB  1 
ATOM   584  C CG  . ASP B 2 32  ? 34.95543 -44.29736 -25.40483 1.000 65.54325  ? 364 ASP B CG  1 
ATOM   585  O OD1 . ASP B 2 32  ? 33.71241 -44.27996 -25.52929 1.000 67.36046  ? 364 ASP B OD1 1 
ATOM   586  O OD2 . ASP B 2 32  ? 35.60724 -45.35512 -25.28482 1.000 73.66677  ? 364 ASP B OD2 1 
ATOM   587  N N   . TYR B 2 33  ? 32.72620 -41.34872 -24.07429 1.000 61.15308  ? 365 TYR B N   1 
ATOM   588  C CA  . TYR B 2 33  ? 31.86256 -41.32632 -22.90149 1.000 63.22888  ? 365 TYR B CA  1 
ATOM   589  C C   . TYR B 2 33  ? 31.43093 -42.72173 -22.47555 1.000 67.95370  ? 365 TYR B C   1 
ATOM   590  O O   . TYR B 2 33  ? 30.96801 -42.89204 -21.34351 1.000 67.36812  ? 365 TYR B O   1 
ATOM   591  C CB  . TYR B 2 33  ? 30.64012 -40.44841 -23.16871 1.000 62.32787  ? 365 TYR B CB  1 
ATOM   592  C CG  . TYR B 2 33  ? 30.99721 -39.00879 -23.45668 1.000 57.47761  ? 365 TYR B CG  1 
ATOM   593  C CD1 . TYR B 2 33  ? 31.15980 -38.09297 -22.42500 1.000 54.46387  ? 365 TYR B CD1 1 
ATOM   594  C CD2 . TYR B 2 33  ? 31.18241 -38.56790 -24.75842 1.000 55.11068  ? 365 TYR B CD2 1 
ATOM   595  C CE1 . TYR B 2 33  ? 31.49184 -36.77675 -22.68330 1.000 49.72640  ? 365 TYR B CE1 1 
ATOM   596  C CE2 . TYR B 2 33  ? 31.51481 -37.25511 -25.02700 1.000 56.65890  ? 365 TYR B CE2 1 
ATOM   597  C CZ  . TYR B 2 33  ? 31.66880 -36.36352 -23.98689 1.000 56.80377  ? 365 TYR B CZ  1 
ATOM   598  O OH  . TYR B 2 33  ? 31.99951 -35.05470 -24.25515 1.000 56.16304  ? 365 TYR B OH  1 
ATOM   599  N N   . SER B 2 34  ? 31.57398 -43.72177 -23.34967 1.000 70.30444  ? 366 SER B N   1 
ATOM   600  C CA  . SER B 2 34  ? 31.30118 -45.09629 -22.94850 1.000 68.21532  ? 366 SER B CA  1 
ATOM   601  C C   . SER B 2 34  ? 32.29689 -45.59824 -21.91263 1.000 68.80274  ? 366 SER B C   1 
ATOM   602  O O   . SER B 2 34  ? 31.99653 -46.56161 -21.20182 1.000 69.94526  ? 366 SER B O   1 
ATOM   603  C CB  . SER B 2 34  ? 31.30483 -46.01765 -24.16845 1.000 68.63912  ? 366 SER B CB  1 
ATOM   604  O OG  . SER B 2 34  ? 30.19760 -45.74818 -25.01142 1.000 74.32763  ? 366 SER B OG  1 
ATOM   605  N N   . VAL B 2 35  ? 33.47381 -44.97551 -21.81719 1.000 67.67316  ? 367 VAL B N   1 
ATOM   606  C CA  . VAL B 2 35  ? 34.38792 -45.28333 -20.72201 1.000 74.84175  ? 367 VAL B CA  1 
ATOM   607  C C   . VAL B 2 35  ? 33.79706 -44.81950 -19.39735 1.000 79.84482  ? 367 VAL B C   1 
ATOM   608  O O   . VAL B 2 35  ? 33.82600 -45.54645 -18.39571 1.000 81.25978  ? 367 VAL B O   1 
ATOM   609  C CB  . VAL B 2 35  ? 35.76675 -44.64863 -20.98113 1.000 79.70071  ? 367 VAL B CB  1 
ATOM   610  C CG1 . VAL B 2 35  ? 36.61778 -44.68604 -19.71851 1.000 81.60294  ? 367 VAL B CG1 1 
ATOM   611  C CG2 . VAL B 2 35  ? 36.47386 -45.36217 -22.12383 1.000 74.45487  ? 367 VAL B CG2 1 
ATOM   612  N N   . LEU B 2 36  ? 33.24899 -43.60427 -19.37119 1.000 73.33217  ? 368 LEU B N   1 
ATOM   613  C CA  . LEU B 2 36  ? 32.56379 -43.12283 -18.17861 1.000 70.50949  ? 368 LEU B CA  1 
ATOM   614  C C   . LEU B 2 36  ? 31.19828 -43.77672 -18.01864 1.000 71.95231  ? 368 LEU B C   1 
ATOM   615  O O   . LEU B 2 36  ? 30.76677 -44.04813 -16.89323 1.000 75.31952  ? 368 LEU B O   1 
ATOM   616  C CB  . LEU B 2 36  ? 32.41993 -41.60132 -18.22610 1.000 70.91217  ? 368 LEU B CB  1 
ATOM   617  C CG  . LEU B 2 36  ? 33.68009 -40.77288 -17.95882 1.000 70.82561  ? 368 LEU B CG  1 
ATOM   618  C CD1 . LEU B 2 36  ? 34.41756 -41.30379 -16.73975 1.000 64.28409  ? 368 LEU B CD1 1 
ATOM   619  C CD2 . LEU B 2 36  ? 34.59737 -40.72461 -19.17330 1.000 69.86681  ? 368 LEU B CD2 1 
ATOM   620  N N   . TYR B 2 37  ? 30.50095 -44.03102 -19.12794 1.000 73.88119  ? 369 TYR B N   1 
ATOM   621  C CA  . TYR B 2 37  ? 29.21402 -44.70971 -19.03632 1.000 75.06140  ? 369 TYR B CA  1 
ATOM   622  C C   . TYR B 2 37  ? 29.38221 -46.12731 -18.51465 1.000 78.90798  ? 369 TYR B C   1 
ATOM   623  O O   . TYR B 2 37  ? 28.44187 -46.69631 -17.95102 1.000 80.71537  ? 369 TYR B O   1 
ATOM   624  C CB  . TYR B 2 37  ? 28.51687 -44.70807 -20.39800 1.000 78.60067  ? 369 TYR B CB  1 
ATOM   625  C CG  . TYR B 2 37  ? 27.00833 -44.80939 -20.32283 1.000 76.36146  ? 369 TYR B CG  1 
ATOM   626  C CD1 . TYR B 2 37  ? 26.27108 -43.91865 -19.55178 1.000 76.36816  ? 369 TYR B CD1 1 
ATOM   627  C CD2 . TYR B 2 37  ? 26.32058 -45.78576 -21.03145 1.000 81.50749  ? 369 TYR B CD2 1 
ATOM   628  C CE1 . TYR B 2 37  ? 24.89129 -44.00540 -19.47754 1.000 76.15827  ? 369 TYR B CE1 1 
ATOM   629  C CE2 . TYR B 2 37  ? 24.94017 -45.87932 -20.96459 1.000 79.85478  ? 369 TYR B CE2 1 
ATOM   630  C CZ  . TYR B 2 37  ? 24.23126 -44.98684 -20.18655 1.000 77.51988  ? 369 TYR B CZ  1 
ATOM   631  O OH  . TYR B 2 37  ? 22.85867 -45.08028 -20.12131 1.000 77.51378  ? 369 TYR B OH  1 
ATOM   632  N N   . ASN B 2 38  ? 30.56792 -46.70681 -18.68600 1.000 79.53043  ? 370 ASN B N   1 
ATOM   633  C CA  . ASN B 2 38  ? 30.90463 -47.95171 -18.01079 1.000 84.13994  ? 370 ASN B CA  1 
ATOM   634  C C   . ASN B 2 38  ? 31.03348 -47.68784 -16.51890 1.000 86.95554  ? 370 ASN B C   1 
ATOM   635  O O   . ASN B 2 38  ? 31.83715 -46.84958 -16.09584 1.000 84.06783  ? 370 ASN B O   1 
ATOM   636  C CB  . ASN B 2 38  ? 32.19823 -48.53410 -18.57324 1.000 84.10018  ? 370 ASN B CB  1 
ATOM   637  C CG  . ASN B 2 38  ? 31.97363 -49.29757 -19.86276 1.000 94.18312  ? 370 ASN B CG  1 
ATOM   638  O OD1 . ASN B 2 38  ? 30.90013 -49.86194 -20.07884 1.000 99.21379  ? 370 ASN B OD1 1 
ATOM   639  N ND2 . ASN B 2 38  ? 32.98067 -49.31648 -20.72914 1.000 93.43749  ? 370 ASN B ND2 1 
ATOM   640  N N   . SER B 2 39  ? 30.24375 -48.40476 -15.72390 1.000 91.40743  ? 371 SER B N   1 
ATOM   641  C CA  . SER B 2 39  ? 30.15176 -48.12377 -14.29861 1.000 87.47284  ? 371 SER B CA  1 
ATOM   642  C C   . SER B 2 39  ? 31.48242 -48.32769 -13.58899 1.000 91.87385  ? 371 SER B C   1 
ATOM   643  O O   . SER B 2 39  ? 31.78343 -49.42701 -13.11418 1.000 94.89815  ? 371 SER B O   1 
ATOM   644  C CB  . SER B 2 39  ? 29.07827 -48.99682 -13.64860 1.000 89.66879  ? 371 SER B CB  1 
ATOM   645  O OG  . SER B 2 39  ? 29.02759 -48.78435 -12.24573 1.000 86.83909  ? 371 SER B OG  1 
ATOM   646  N N   . ALA B 2 40  ? 32.28666 -47.27139 -13.50774 1.000 88.31083  ? 372 ALA B N   1 
ATOM   647  C CA  . ALA B 2 40  ? 33.41820 -47.27980 -12.59224 1.000 86.65864  ? 372 ALA B CA  1 
ATOM   648  C C   . ALA B 2 40  ? 32.90515 -46.86645 -11.21986 1.000 80.48964  ? 372 ALA B C   1 
ATOM   649  O O   . ALA B 2 40  ? 33.46717 -45.97112 -10.58187 1.000 83.08792  ? 372 ALA B O   1 
ATOM   650  C CB  . ALA B 2 40  ? 34.53821 -46.35716 -13.07568 1.000 82.90039  ? 372 ALA B CB  1 
ATOM   651  N N   . SER B 2 41  ? 31.83643 -47.52978 -10.76483 1.000 80.39471  ? 373 SER B N   1 
ATOM   652  C CA  . SER B 2 41  ? 31.06010 -47.11344 -9.60177  1.000 82.84149  ? 373 SER B CA  1 
ATOM   653  C C   . SER B 2 41  ? 30.54341 -45.69140 -9.80111  1.000 75.52632  ? 373 SER B C   1 
ATOM   654  O O   . SER B 2 41  ? 31.22767 -44.72304 -9.45651  1.000 75.44028  ? 373 SER B O   1 
ATOM   655  C CB  . SER B 2 41  ? 31.89349 -47.22184 -8.31854  1.000 87.30529  ? 373 SER B CB  1 
ATOM   656  O OG  . SER B 2 41  ? 31.13343 -46.84992 -7.18264  1.000 88.12101  ? 373 SER B OG  1 
ATOM   657  N N   . PHE B 2 42  ? 29.34804 -45.55389 -10.37557 1.000 69.08396  ? 374 PHE B N   1 
ATOM   658  C CA  . PHE B 2 42  ? 28.70610 -44.25360 -10.57546 1.000 65.25851  ? 374 PHE B CA  1 
ATOM   659  C C   . PHE B 2 42  ? 27.27977 -44.34069 -10.03977 1.000 62.05266  ? 374 PHE B C   1 
ATOM   660  O O   . PHE B 2 42  ? 26.41423 -44.96702 -10.65773 1.000 62.69599  ? 374 PHE B O   1 
ATOM   661  C CB  . PHE B 2 42  ? 28.72384 -43.84258 -12.04590 1.000 62.04839  ? 374 PHE B CB  1 
ATOM   662  C CG  . PHE B 2 42  ? 30.03558 -43.26637 -12.49998 1.000 63.69862  ? 374 PHE B CG  1 
ATOM   663  C CD1 . PHE B 2 42  ? 30.84898 -42.57753 -11.61607 1.000 69.35110  ? 374 PHE B CD1 1 
ATOM   664  C CD2 . PHE B 2 42  ? 30.45611 -43.41367 -13.80841 1.000 60.36896  ? 374 PHE B CD2 1 
ATOM   665  C CE1 . PHE B 2 42  ? 32.05748 -42.04765 -12.03010 1.000 64.64885  ? 374 PHE B CE1 1 
ATOM   666  C CE2 . PHE B 2 42  ? 31.66271 -42.88538 -14.22585 1.000 59.13728  ? 374 PHE B CE2 1 
ATOM   667  C CZ  . PHE B 2 42  ? 32.46286 -42.20238 -13.33718 1.000 58.92073  ? 374 PHE B CZ  1 
ATOM   668  N N   . SER B 2 43  ? 27.03528 -43.70982 -8.88966  1.000 54.17900  ? 375 SER B N   1 
ATOM   669  C CA  . SER B 2 43  ? 25.71120 -43.78143 -8.28080  1.000 59.81955  ? 375 SER B CA  1 
ATOM   670  C C   . SER B 2 43  ? 24.70760 -42.90557 -9.01648  1.000 54.98288  ? 375 SER B C   1 
ATOM   671  O O   . SER B 2 43  ? 23.50835 -43.20720 -9.02413  1.000 57.09993  ? 375 SER B O   1 
ATOM   672  C CB  . SER B 2 43  ? 25.78592 -43.37992 -6.80683  1.000 50.59111  ? 375 SER B CB  1 
ATOM   673  O OG  . SER B 2 43  ? 26.12996 -42.01184 -6.66347  1.000 56.68791  ? 375 SER B OG  1 
ATOM   674  N N   . THR B 2 44  ? 25.17237 -41.82650 -9.63440  1.000 56.16325  ? 376 THR B N   1 
ATOM   675  C CA  . THR B 2 44  ? 24.31965 -40.92804 -10.39509 1.000 49.52258  ? 376 THR B CA  1 
ATOM   676  C C   . THR B 2 44  ? 24.95682 -40.68481 -11.75351 1.000 48.07026  ? 376 THR B C   1 
ATOM   677  O O   . THR B 2 44  ? 26.18318 -40.58460 -11.86468 1.000 51.34884  ? 376 THR B O   1 
ATOM   678  C CB  . THR B 2 44  ? 24.10828 -39.59758 -9.65238  1.000 48.44472  ? 376 THR B CB  1 
ATOM   679  O OG1 . THR B 2 44  ? 23.51813 -39.85105 -8.37139  1.000 54.28186  ? 376 THR B OG1 1 
ATOM   680  C CG2 . THR B 2 44  ? 23.19755 -38.65822 -10.44074 1.000 48.37798  ? 376 THR B CG2 1 
ATOM   681  N N   . PHE B 2 45  ? 24.11541 -40.61839 -12.79198 1.000 49.23243  ? 377 PHE B N   1 
ATOM   682  C CA  . PHE B 2 45  ? 24.56557 -40.32489 -14.15186 1.000 47.28012  ? 377 PHE B CA  1 
ATOM   683  C C   . PHE B 2 45  ? 23.32864 -39.82688 -14.90307 1.000 49.26598  ? 377 PHE B C   1 
ATOM   684  O O   . PHE B 2 45  ? 22.71412 -40.53758 -15.70193 1.000 61.62410  ? 377 PHE B O   1 
ATOM   685  C CB  . PHE B 2 45  ? 25.19650 -41.54214 -14.82830 1.000 47.46622  ? 377 PHE B CB  1 
ATOM   686  C CG  . PHE B 2 45  ? 26.15584 -41.19977 -15.94213 1.000 52.98955  ? 377 PHE B CG  1 
ATOM   687  C CD1 . PHE B 2 45  ? 25.72193 -40.51251 -17.06417 1.000 54.46739  ? 377 PHE B CD1 1 
ATOM   688  C CD2 . PHE B 2 45  ? 27.48920 -41.57552 -15.86679 1.000 53.02541  ? 377 PHE B CD2 1 
ATOM   689  C CE1 . PHE B 2 45  ? 26.59930 -40.19883 -18.08685 1.000 58.77271  ? 377 PHE B CE1 1 
ATOM   690  C CE2 . PHE B 2 45  ? 28.36756 -41.26798 -16.88247 1.000 52.57716  ? 377 PHE B CE2 1 
ATOM   691  C CZ  . PHE B 2 45  ? 27.92727 -40.57994 -17.99256 1.000 60.97805  ? 377 PHE B CZ  1 
ATOM   692  N N   . LYS B 2 46  ? 22.94915 -38.58752 -14.60971 1.000 51.36890  ? 378 LYS B N   1 
ATOM   693  C CA  . LYS B 2 46  ? 21.75611 -37.96216 -15.16188 1.000 53.28799  ? 378 LYS B CA  1 
ATOM   694  C C   . LYS B 2 46  ? 22.16143 -36.86173 -16.13435 1.000 49.98673  ? 378 LYS B C   1 
ATOM   695  O O   . LYS B 2 46  ? 22.94787 -35.97312 -15.78718 1.000 48.37341  ? 378 LYS B O   1 
ATOM   696  C CB  . LYS B 2 46  ? 20.87503 -37.39380 -14.04568 1.000 55.00798  ? 378 LYS B CB  1 
ATOM   697  C CG  . LYS B 2 46  ? 20.51203 -38.41619 -12.98868 1.000 53.50360  ? 378 LYS B CG  1 
ATOM   698  C CD  . LYS B 2 46  ? 19.48448 -37.87739 -12.01510 1.000 63.41189  ? 378 LYS B CD  1 
ATOM   699  C CE  . LYS B 2 46  ? 19.14417 -38.92117 -10.96396 1.000 53.51366  ? 378 LYS B CE  1 
ATOM   700  N NZ  . LYS B 2 46  ? 17.95507 -38.51273 -10.17163 1.000 61.44344  ? 378 LYS B NZ  1 
ATOM   701  N N   . CYS B 2 47  ? 21.63085 -36.92739 -17.34992 1.000 56.79080  ? 379 CYS B N   1 
ATOM   702  C CA  . CYS B 2 47  ? 21.91701 -35.94884 -18.38598 1.000 47.17814  ? 379 CYS B CA  1 
ATOM   703  C C   . CYS B 2 47  ? 20.64350 -35.19689 -18.74168 1.000 49.99295  ? 379 CYS B C   1 
ATOM   704  O O   . CYS B 2 47  ? 19.53746 -35.73735 -18.65051 1.000 47.07878  ? 379 CYS B O   1 
ATOM   705  C CB  . CYS B 2 47  ? 22.49989 -36.61583 -19.63175 1.000 44.72662  ? 379 CYS B CB  1 
ATOM   706  S SG  . CYS B 2 47  ? 23.99455 -37.57535 -19.32809 1.000 50.38411  ? 379 CYS B SG  1 
ATOM   707  N N   . TYR B 2 48  ? 20.81192 -33.93857 -19.14000 1.000 50.72912  ? 380 TYR B N   1 
ATOM   708  C CA  . TYR B 2 48  ? 19.69782 -33.04385 -19.41420 1.000 52.76809  ? 380 TYR B CA  1 
ATOM   709  C C   . TYR B 2 48  ? 19.90583 -32.36803 -20.76091 1.000 50.91665  ? 380 TYR B C   1 
ATOM   710  O O   . TYR B 2 48  ? 21.00439 -31.89368 -21.06361 1.000 51.23144  ? 380 TYR B O   1 
ATOM   711  C CB  . TYR B 2 48  ? 19.55440 -31.99289 -18.30610 1.000 47.14955  ? 380 TYR B CB  1 
ATOM   712  C CG  . TYR B 2 48  ? 19.42238 -32.58808 -16.92011 1.000 49.92732  ? 380 TYR B CG  1 
ATOM   713  C CD1 . TYR B 2 48  ? 20.54554 -32.87220 -16.15320 1.000 47.67278  ? 380 TYR B CD1 1 
ATOM   714  C CD2 . TYR B 2 48  ? 18.17445 -32.86931 -16.38080 1.000 49.53507  ? 380 TYR B CD2 1 
ATOM   715  C CE1 . TYR B 2 48  ? 20.42843 -33.41845 -14.88688 1.000 50.51142  ? 380 TYR B CE1 1 
ATOM   716  C CE2 . TYR B 2 48  ? 18.04723 -33.41460 -15.11670 1.000 50.78464  ? 380 TYR B CE2 1 
ATOM   717  C CZ  . TYR B 2 48  ? 19.17658 -33.68736 -14.37384 1.000 50.14722  ? 380 TYR B CZ  1 
ATOM   718  O OH  . TYR B 2 48  ? 19.05059 -34.22960 -13.11499 1.000 55.60150  ? 380 TYR B OH  1 
ATOM   719  N N   . GLY B 2 49  ? 18.84717 -32.32772 -21.56764 1.000 55.54043  ? 381 GLY B N   1 
ATOM   720  C CA  . GLY B 2 49  ? 18.95202 -31.77653 -22.90365 1.000 53.98942  ? 381 GLY B CA  1 
ATOM   721  C C   . GLY B 2 49  ? 19.70009 -32.64079 -23.89073 1.000 52.87991  ? 381 GLY B C   1 
ATOM   722  O O   . GLY B 2 49  ? 19.89136 -32.22375 -25.03728 1.000 54.35402  ? 381 GLY B O   1 
ATOM   723  N N   . VAL B 2 50  ? 20.12110 -33.83490 -23.48281 1.000 57.05515  ? 382 VAL B N   1 
ATOM   724  C CA  . VAL B 2 50  ? 20.89827 -34.72902 -24.33219 1.000 49.78471  ? 382 VAL B CA  1 
ATOM   725  C C   . VAL B 2 50  ? 20.76642 -36.13639 -23.76697 1.000 55.31371  ? 382 VAL B C   1 
ATOM   726  O O   . VAL B 2 50  ? 20.74909 -36.33093 -22.54767 1.000 57.45849  ? 382 VAL B O   1 
ATOM   727  C CB  . VAL B 2 50  ? 22.37478 -34.27061 -24.41886 1.000 49.87326  ? 382 VAL B CB  1 
ATOM   728  C CG1 . VAL B 2 50  ? 22.94234 -34.02333 -23.02782 1.000 53.49125  ? 382 VAL B CG1 1 
ATOM   729  C CG2 . VAL B 2 50  ? 23.21431 -35.29115 -25.16152 1.000 48.94897  ? 382 VAL B CG2 1 
ATOM   730  N N   . SER B 2 51  ? 20.65676 -37.11991 -24.66558 1.000 52.80262  ? 383 SER B N   1 
ATOM   731  C CA  . SER B 2 51  ? 20.51245 -38.50951 -24.25245 1.000 52.17101  ? 383 SER B CA  1 
ATOM   732  C C   . SER B 2 51  ? 21.87621 -39.10166 -23.89849 1.000 56.55242  ? 383 SER B C   1 
ATOM   733  O O   . SER B 2 51  ? 22.85278 -38.88338 -24.62017 1.000 57.39579  ? 383 SER B O   1 
ATOM   734  C CB  . SER B 2 51  ? 19.85930 -39.33235 -25.35986 1.000 64.87449  ? 383 SER B CB  1 
ATOM   735  O OG  . SER B 2 51  ? 19.79136 -40.70381 -25.00902 1.000 68.60657  ? 383 SER B OG  1 
ATOM   736  N N   . PRO B 2 52  ? 21.96796 -39.85359 -22.79580 1.000 60.07995  ? 384 PRO B N   1 
ATOM   737  C CA  . PRO B 2 52  ? 23.27592 -40.39367 -22.38868 1.000 56.92125  ? 384 PRO B CA  1 
ATOM   738  C C   . PRO B 2 52  ? 23.82182 -41.44263 -23.33927 1.000 60.48343  ? 384 PRO B C   1 
ATOM   739  O O   . PRO B 2 52  ? 25.04604 -41.56088 -23.47338 1.000 65.67601  ? 384 PRO B O   1 
ATOM   740  C CB  . PRO B 2 52  ? 22.99362 -40.98466 -20.99988 1.000 61.30635  ? 384 PRO B CB  1 
ATOM   741  C CG  . PRO B 2 52  ? 21.53308 -41.30117 -21.01918 1.000 62.05430  ? 384 PRO B CG  1 
ATOM   742  C CD  . PRO B 2 52  ? 20.89474 -40.22684 -21.85777 1.000 62.56800  ? 384 PRO B CD  1 
ATOM   743  N N   . THR B 2 53  ? 22.95770 -42.21346 -23.99795 1.000 64.48686  ? 385 THR B N   1 
ATOM   744  C CA  . THR B 2 53  ? 23.41481 -43.20802 -24.95881 1.000 63.07842  ? 385 THR B CA  1 
ATOM   745  C C   . THR B 2 53  ? 23.86410 -42.59377 -26.27757 1.000 58.93275  ? 385 THR B C   1 
ATOM   746  O O   . THR B 2 53  ? 24.44524 -43.30318 -27.10570 1.000 52.25063  ? 385 THR B O   1 
ATOM   747  C CB  . THR B 2 53  ? 22.30946 -44.23337 -25.22332 1.000 62.20189  ? 385 THR B CB  1 
ATOM   748  O OG1 . THR B 2 53  ? 21.11479 -43.55554 -25.63217 1.000 63.50959  ? 385 THR B OG1 1 
ATOM   749  C CG2 . THR B 2 53  ? 22.02376 -45.04448 -23.96765 1.000 66.45056  ? 385 THR B CG2 1 
ATOM   750  N N   . LYS B 2 54  ? 23.61827 -41.30172 -26.48922 1.000 56.08196  ? 386 LYS B N   1 
ATOM   751  C CA  . LYS B 2 54  ? 23.99222 -40.62513 -27.72331 1.000 57.00868  ? 386 LYS B CA  1 
ATOM   752  C C   . LYS B 2 54  ? 25.16754 -39.67426 -27.53430 1.000 57.11611  ? 386 LYS B C   1 
ATOM   753  O O   . LYS B 2 54  ? 25.46378 -38.88560 -28.43756 1.000 54.65130  ? 386 LYS B O   1 
ATOM   754  C CB  . LYS B 2 54  ? 22.79200 -39.86534 -28.29338 1.000 56.48455  ? 386 LYS B CB  1 
ATOM   755  C CG  . LYS B 2 54  ? 21.47777 -40.62968 -28.23064 1.000 59.24950  ? 386 LYS B CG  1 
ATOM   756  C CD  . LYS B 2 54  ? 21.56905 -41.98110 -28.91922 1.000 60.78044  ? 386 LYS B CD  1 
ATOM   757  C CE  . LYS B 2 54  ? 20.27316 -42.76117 -28.76396 1.000 64.64061  ? 386 LYS B CE  1 
ATOM   758  N NZ  . LYS B 2 54  ? 20.37325 -44.12969 -29.34121 1.000 61.92057  ? 386 LYS B NZ  1 
ATOM   759  N N   . LEU B 2 55  ? 25.84303 -39.72907 -26.38238 1.000 60.28342  ? 387 LEU B N   1 
ATOM   760  C CA  . LEU B 2 55  ? 26.95510 -38.81708 -26.12842 1.000 55.15872  ? 387 LEU B CA  1 
ATOM   761  C C   . LEU B 2 55  ? 28.10467 -39.05571 -27.09965 1.000 55.95764  ? 387 LEU B C   1 
ATOM   762  O O   . LEU B 2 55  ? 28.75128 -38.10417 -27.55304 1.000 56.35878  ? 387 LEU B O   1 
ATOM   763  C CB  . LEU B 2 55  ? 27.44243 -38.96682 -24.68671 1.000 58.34614  ? 387 LEU B CB  1 
ATOM   764  C CG  . LEU B 2 55  ? 26.48686 -38.61722 -23.54389 1.000 55.00986  ? 387 LEU B CG  1 
ATOM   765  C CD1 . LEU B 2 55  ? 27.15792 -38.88455 -22.20983 1.000 49.90662  ? 387 LEU B CD1 1 
ATOM   766  C CD2 . LEU B 2 55  ? 26.03399 -37.17164 -23.63063 1.000 51.33163  ? 387 LEU B CD2 1 
ATOM   767  N N   . ASN B 2 56  ? 28.37778 -40.31965 -27.42917 1.000 54.29620  ? 388 ASN B N   1 
ATOM   768  C CA  . ASN B 2 56  ? 29.48800 -40.63983 -28.31834 1.000 59.29582  ? 388 ASN B CA  1 
ATOM   769  C C   . ASN B 2 56  ? 29.22824 -40.24414 -29.76629 1.000 57.65362  ? 388 ASN B C   1 
ATOM   770  O O   . ASN B 2 56  ? 30.17407 -40.22910 -30.56051 1.000 59.30079  ? 388 ASN B O   1 
ATOM   771  C CB  . ASN B 2 56  ? 29.80932 -42.13422 -28.24087 1.000 60.26024  ? 388 ASN B CB  1 
ATOM   772  C CG  . ASN B 2 56  ? 30.82722 -42.45672 -27.16364 1.000 63.48810  ? 388 ASN B CG  1 
ATOM   773  O OD1 . ASN B 2 56  ? 31.23697 -41.58387 -26.39794 1.000 59.56390  ? 388 ASN B OD1 1 
ATOM   774  N ND2 . ASN B 2 56  ? 31.24234 -43.71711 -27.10082 1.000 63.20371  ? 388 ASN B ND2 1 
ATOM   775  N N   . ASP B 2 57  ? 27.98771 -39.92528 -30.12857 1.000 59.32350  ? 389 ASP B N   1 
ATOM   776  C CA  . ASP B 2 57  ? 27.65359 -39.52351 -31.48915 1.000 56.62335  ? 389 ASP B CA  1 
ATOM   777  C C   . ASP B 2 57  ? 27.65843 -38.01455 -31.68262 1.000 53.55982  ? 389 ASP B C   1 
ATOM   778  O O   . ASP B 2 57  ? 27.45327 -37.54884 -32.80803 1.000 56.43443  ? 389 ASP B O   1 
ATOM   779  C CB  . ASP B 2 57  ? 26.27500 -40.06720 -31.88344 1.000 51.70861  ? 389 ASP B CB  1 
ATOM   780  C CG  . ASP B 2 57  ? 26.15707 -41.56270 -31.68771 1.000 58.87980  ? 389 ASP B CG  1 
ATOM   781  O OD1 . ASP B 2 57  ? 27.17716 -42.26652 -31.84135 1.000 62.22791  ? 389 ASP B OD1 1 
ATOM   782  O OD2 . ASP B 2 57  ? 25.04060 -42.03416 -31.38031 1.000 55.71003  ? 389 ASP B OD2 1 
ATOM   783  N N   . LEU B 2 58  ? 27.88449 -37.24194 -30.62809 1.000 52.60071  ? 390 LEU B N   1 
ATOM   784  C CA  . LEU B 2 58  ? 27.66590 -35.80572 -30.67036 1.000 49.62407  ? 390 LEU B CA  1 
ATOM   785  C C   . LEU B 2 58  ? 28.97919 -35.04056 -30.56989 1.000 45.22827  ? 390 LEU B C   1 
ATOM   786  O O   . LEU B 2 58  ? 30.03168 -35.58273 -30.22181 1.000 43.88023  ? 390 LEU B O   1 
ATOM   787  C CB  . LEU B 2 58  ? 26.71014 -35.37865 -29.55214 1.000 48.51823  ? 390 LEU B CB  1 
ATOM   788  C CG  . LEU B 2 58  ? 25.27715 -35.88544 -29.72076 1.000 53.88564  ? 390 LEU B CG  1 
ATOM   789  C CD1 . LEU B 2 58  ? 24.44979 -35.59535 -28.48439 1.000 58.71519  ? 390 LEU B CD1 1 
ATOM   790  C CD2 . LEU B 2 58  ? 24.63130 -35.26598 -30.95271 1.000 53.21869  ? 390 LEU B CD2 1 
ATOM   791  N N   . CYS B 2 59  ? 28.89139 -33.75634 -30.90349 1.000 41.95571  ? 391 CYS B N   1 
ATOM   792  C CA  . CYS B 2 59  ? 29.99329 -32.81484 -30.80606 1.000 44.90778  ? 391 CYS B CA  1 
ATOM   793  C C   . CYS B 2 59  ? 29.48261 -31.54654 -30.13669 1.000 42.25183  ? 391 CYS B C   1 
ATOM   794  O O   . CYS B 2 59  ? 28.28792 -31.24136 -30.17732 1.000 41.98871  ? 391 CYS B O   1 
ATOM   795  C CB  . CYS B 2 59  ? 30.57850 -32.47780 -32.18586 1.000 50.37353  ? 391 CYS B CB  1 
ATOM   796  S SG  . CYS B 2 59  ? 31.32519 -33.85090 -33.10911 1.000 57.46090  ? 391 CYS B SG  1 
ATOM   797  N N   . PHE B 2 60  ? 30.39530 -30.80022 -29.51826 1.000 36.23241  ? 392 PHE B N   1 
ATOM   798  C CA  . PHE B 2 60  ? 30.01216 -29.58869 -28.81052 1.000 40.42718  ? 392 PHE B CA  1 
ATOM   799  C C   . PHE B 2 60  ? 31.09866 -28.53319 -28.94358 1.000 42.58079  ? 392 PHE B C   1 
ATOM   800  O O   . PHE B 2 60  ? 32.28173 -28.84558 -29.10617 1.000 43.13974  ? 392 PHE B O   1 
ATOM   801  C CB  . PHE B 2 60  ? 29.72019 -29.87331 -27.33187 1.000 41.17222  ? 392 PHE B CB  1 
ATOM   802  C CG  . PHE B 2 60  ? 28.50133 -30.71878 -27.11748 1.000 40.09643  ? 392 PHE B CG  1 
ATOM   803  C CD1 . PHE B 2 60  ? 27.24153 -30.14651 -27.11688 1.000 35.67017  ? 392 PHE B CD1 1 
ATOM   804  C CD2 . PHE B 2 60  ? 28.61292 -32.08825 -26.94236 1.000 38.62017  ? 392 PHE B CD2 1 
ATOM   805  C CE1 . PHE B 2 60  ? 26.11669 -30.92012 -26.93138 1.000 37.10066  ? 392 PHE B CE1 1 
ATOM   806  C CE2 . PHE B 2 60  ? 27.49203 -32.86845 -26.75701 1.000 38.91176  ? 392 PHE B CE2 1 
ATOM   807  C CZ  . PHE B 2 60  ? 26.24157 -32.28386 -26.75007 1.000 42.03479  ? 392 PHE B CZ  1 
ATOM   808  N N   . THR B 2 61  ? 30.66959 -27.27068 -28.87542 1.000 43.43543  ? 393 THR B N   1 
ATOM   809  C CA  . THR B 2 61  ? 31.59450 -26.15167 -29.01951 1.000 46.14338  ? 393 THR B CA  1 
ATOM   810  C C   . THR B 2 61  ? 32.63807 -26.14731 -27.91125 1.000 51.17989  ? 393 THR B C   1 
ATOM   811  O O   . THR B 2 61  ? 33.81851 -25.87894 -28.16114 1.000 49.16442  ? 393 THR B O   1 
ATOM   812  C CB  . THR B 2 61  ? 30.81685 -24.83497 -29.02660 1.000 52.01076  ? 393 THR B CB  1 
ATOM   813  O OG1 . THR B 2 61  ? 29.94737 -24.79980 -30.16563 1.000 53.55390  ? 393 THR B OG1 1 
ATOM   814  C CG2 . THR B 2 61  ? 31.76638 -23.64635 -29.08008 1.000 55.52318  ? 393 THR B CG2 1 
ATOM   815  N N   . ASN B 2 62  ? 32.22336 -26.43833 -26.68071 1.000 52.92119  ? 394 ASN B N   1 
ATOM   816  C CA  . ASN B 2 62  ? 33.14474 -26.46749 -25.55544 1.000 46.55205  ? 394 ASN B CA  1 
ATOM   817  C C   . ASN B 2 62  ? 32.52647 -27.29918 -24.44223 1.000 45.86454  ? 394 ASN B C   1 
ATOM   818  O O   . ASN B 2 62  ? 31.30189 -27.36218 -24.30333 1.000 44.37601  ? 394 ASN B O   1 
ATOM   819  C CB  . ASN B 2 62  ? 33.46954 -25.05310 -25.05878 1.000 49.22936  ? 394 ASN B CB  1 
ATOM   820  C CG  . ASN B 2 62  ? 34.75746 -24.99743 -24.26158 1.000 57.37237  ? 394 ASN B CG  1 
ATOM   821  O OD1 . ASN B 2 62  ? 34.74047 -24.92061 -23.03067 1.000 55.77652  ? 394 ASN B OD1 1 
ATOM   822  N ND2 . ASN B 2 62  ? 35.88646 -25.04091 -24.96188 1.000 51.15157  ? 394 ASN B ND2 1 
ATOM   823  N N   . VAL B 2 63  ? 33.38722 -27.93880 -23.65589 1.000 46.95019  ? 395 VAL B N   1 
ATOM   824  C CA  . VAL B 2 63  ? 32.96736 -28.78534 -22.54528 1.000 46.45204  ? 395 VAL B CA  1 
ATOM   825  C C   . VAL B 2 63  ? 33.59519 -28.25215 -21.26543 1.000 42.14896  ? 395 VAL B C   1 
ATOM   826  O O   . VAL B 2 63  ? 34.82022 -28.09760 -21.18459 1.000 43.50558  ? 395 VAL B O   1 
ATOM   827  C CB  . VAL B 2 63  ? 33.34963 -30.25623 -22.76955 1.000 46.84485  ? 395 VAL B CB  1 
ATOM   828  C CG1 . VAL B 2 63  ? 33.16674 -31.04980 -21.48291 1.000 41.75521  ? 395 VAL B CG1 1 
ATOM   829  C CG2 . VAL B 2 63  ? 32.50906 -30.85054 -23.88843 1.000 42.93947  ? 395 VAL B CG2 1 
ATOM   830  N N   . TYR B 2 64  ? 32.75668 -27.96875 -20.27332 1.000 44.57086  ? 396 TYR B N   1 
ATOM   831  C CA  . TYR B 2 64  ? 33.19990 -27.61114 -18.93360 1.000 40.36793  ? 396 TYR B CA  1 
ATOM   832  C C   . TYR B 2 64  ? 32.99718 -28.79583 -18.00034 1.000 37.12012  ? 396 TYR B C   1 
ATOM   833  O O   . TYR B 2 64  ? 31.95307 -29.45266 -18.03297 1.000 37.88966  ? 396 TYR B O   1 
ATOM   834  C CB  . TYR B 2 64  ? 32.43288 -26.39931 -18.40185 1.000 38.82212  ? 396 TYR B CB  1 
ATOM   835  C CG  . TYR B 2 64  ? 32.93602 -25.06347 -18.89909 1.000 41.22261  ? 396 TYR B CG  1 
ATOM   836  C CD1 . TYR B 2 64  ? 34.28798 -24.84778 -19.12912 1.000 41.58621  ? 396 TYR B CD1 1 
ATOM   837  C CD2 . TYR B 2 64  ? 32.05560 -24.01369 -19.13269 1.000 50.49955  ? 396 TYR B CD2 1 
ATOM   838  C CE1 . TYR B 2 64  ? 34.74920 -23.62502 -19.58039 1.000 45.65495  ? 396 TYR B CE1 1 
ATOM   839  C CE2 . TYR B 2 64  ? 32.50664 -22.78752 -19.58271 1.000 47.62214  ? 396 TYR B CE2 1 
ATOM   840  C CZ  . TYR B 2 64  ? 33.85392 -22.59868 -19.80509 1.000 53.78805  ? 396 TYR B CZ  1 
ATOM   841  O OH  . TYR B 2 64  ? 34.30582 -21.37878 -20.25502 1.000 58.31323  ? 396 TYR B OH  1 
ATOM   842  N N   . ALA B 2 65  ? 33.99983 -29.06635 -17.17063 1.000 39.96678  ? 397 ALA B N   1 
ATOM   843  C CA  . ALA B 2 65  ? 33.94636 -30.14770 -16.19191 1.000 40.56491  ? 397 ALA B CA  1 
ATOM   844  C C   . ALA B 2 65  ? 34.07377 -29.54408 -14.79923 1.000 42.14266  ? 397 ALA B C   1 
ATOM   845  O O   . ALA B 2 65  ? 35.15274 -29.07988 -14.41536 1.000 42.11929  ? 397 ALA B O   1 
ATOM   846  C CB  . ALA B 2 65  ? 35.04528 -31.17802 -16.44437 1.000 40.46161  ? 397 ALA B CB  1 
ATOM   847  N N   . ASP B 2 66  ? 32.97556 -29.54942 -14.05013 1.000 37.39871  ? 398 ASP B N   1 
ATOM   848  C CA  . ASP B 2 66  ? 32.95279 -29.06397 -12.67868 1.000 42.87696  ? 398 ASP B CA  1 
ATOM   849  C C   . ASP B 2 66  ? 32.95743 -30.24343 -11.71669 1.000 40.53812  ? 398 ASP B C   1 
ATOM   850  O O   . ASP B 2 66  ? 32.30091 -31.25892 -11.96290 1.000 39.93996  ? 398 ASP B O   1 
ATOM   851  C CB  . ASP B 2 66  ? 31.72554 -28.18574 -12.42835 1.000 38.12329  ? 398 ASP B CB  1 
ATOM   852  C CG  . ASP B 2 66  ? 31.68942 -26.96905 -13.32917 1.000 37.41811  ? 398 ASP B CG  1 
ATOM   853  O OD1 . ASP B 2 66  ? 32.75901 -26.57625 -13.84087 1.000 39.08030  ? 398 ASP B OD1 1 
ATOM   854  O OD2 . ASP B 2 66  ? 30.59368 -26.40327 -13.52403 1.000 37.52425  ? 398 ASP B OD2 1 
ATOM   855  N N   . SER B 2 67  ? 33.70204 -30.10523 -10.62044 1.000 38.59945  ? 399 SER B N   1 
ATOM   856  C CA  . SER B 2 67  ? 33.85891 -31.18492 -9.65736  1.000 33.93411  ? 399 SER B CA  1 
ATOM   857  C C   . SER B 2 67  ? 33.87528 -30.62361 -8.24350  1.000 43.36132  ? 399 SER B C   1 
ATOM   858  O O   . SER B 2 67  ? 34.41411 -29.53862 -8.00297  1.000 44.74307  ? 399 SER B O   1 
ATOM   859  C CB  . SER B 2 67  ? 35.14118 -31.98584 -9.92167  1.000 34.94171  ? 399 SER B CB  1 
ATOM   860  O OG  . SER B 2 67  ? 36.27592 -31.14021 -9.96715  1.000 41.05171  ? 399 SER B OG  1 
ATOM   861  N N   . PHE B 2 68  ? 33.28689 -31.37425 -7.31569  1.000 39.00200  ? 400 PHE B N   1 
ATOM   862  C CA  . PHE B 2 68  ? 33.19245 -30.98562 -5.91147  1.000 42.26137  ? 400 PHE B CA  1 
ATOM   863  C C   . PHE B 2 68  ? 32.74115 -32.20506 -5.11420  1.000 44.38312  ? 400 PHE B C   1 
ATOM   864  O O   . PHE B 2 68  ? 32.54490 -33.29404 -5.66325  1.000 44.64399  ? 400 PHE B O   1 
ATOM   865  C CB  . PHE B 2 68  ? 32.23677 -29.80593 -5.71720  1.000 39.87700  ? 400 PHE B CB  1 
ATOM   866  C CG  . PHE B 2 68  ? 30.89265 -29.99717 -6.36549  1.000 38.26461  ? 400 PHE B CG  1 
ATOM   867  C CD1 . PHE B 2 68  ? 29.90086 -30.73409 -5.73856  1.000 38.10827  ? 400 PHE B CD1 1 
ATOM   868  C CD2 . PHE B 2 68  ? 30.61929 -29.43302 -7.59933  1.000 38.94200  ? 400 PHE B CD2 1 
ATOM   869  C CE1 . PHE B 2 68  ? 28.66639 -30.90886 -6.33287  1.000 37.24407  ? 400 PHE B CE1 1 
ATOM   870  C CE2 . PHE B 2 68  ? 29.38530 -29.60450 -8.19705  1.000 40.39779  ? 400 PHE B CE2 1 
ATOM   871  C CZ  . PHE B 2 68  ? 28.40893 -30.34447 -7.56257  1.000 33.67603  ? 400 PHE B CZ  1 
ATOM   872  N N   . VAL B 2 69  ? 32.56626 -32.00711 -3.80910  1.000 41.87944  ? 401 VAL B N   1 
ATOM   873  C CA  . VAL B 2 69  ? 32.13309 -33.05444 -2.89116  1.000 42.95629  ? 401 VAL B CA  1 
ATOM   874  C C   . VAL B 2 69  ? 30.97558 -32.52017 -2.06055  1.000 41.50831  ? 401 VAL B C   1 
ATOM   875  O O   . VAL B 2 69  ? 31.03960 -31.39533 -1.55318  1.000 42.46696  ? 401 VAL B O   1 
ATOM   876  C CB  . VAL B 2 69  ? 33.28237 -33.52453 -1.97808  1.000 42.00405  ? 401 VAL B CB  1 
ATOM   877  C CG1 . VAL B 2 69  ? 32.74152 -34.28691 -0.77594  1.000 40.73889  ? 401 VAL B CG1 1 
ATOM   878  C CG2 . VAL B 2 69  ? 34.25198 -34.39066 -2.76077  1.000 45.45907  ? 401 VAL B CG2 1 
ATOM   879  N N   . ILE B 2 70  ? 29.91814 -33.32114 -1.92974  1.000 41.69177  ? 402 ILE B N   1 
ATOM   880  C CA  . ILE B 2 70  ? 28.75855 -32.99774 -1.11201  1.000 37.86575  ? 402 ILE B CA  1 
ATOM   881  C C   . ILE B 2 70  ? 28.27668 -34.27072 -0.42609  1.000 40.89059  ? 402 ILE B C   1 
ATOM   882  O O   . ILE B 2 70  ? 28.84873 -35.35049 -0.59658  1.000 40.94168  ? 402 ILE B O   1 
ATOM   883  C CB  . ILE B 2 70  ? 27.61387 -32.36835 -1.93245  1.000 38.01042  ? 402 ILE B CB  1 
ATOM   884  C CG1 . ILE B 2 70  ? 27.30271 -33.23078 -3.15648  1.000 35.53663  ? 402 ILE B CG1 1 
ATOM   885  C CG2 . ILE B 2 70  ? 27.94671 -30.93795 -2.31847  1.000 36.24537  ? 402 ILE B CG2 1 
ATOM   886  C CD1 . ILE B 2 70  ? 26.11210 -32.75270 -3.94711  1.000 39.08852  ? 402 ILE B CD1 1 
ATOM   887  N N   . ARG B 2 71  ? 27.21172 -34.13228 0.36030   1.000 43.49990  ? 403 ARG B N   1 
ATOM   888  C CA  . ARG B 2 71  ? 26.54782 -35.27003 0.97520   1.000 46.65201  ? 403 ARG B CA  1 
ATOM   889  C C   . ARG B 2 71  ? 25.70941 -36.01821 -0.05573  1.000 38.61868  ? 403 ARG B C   1 
ATOM   890  O O   . ARG B 2 71  ? 25.29408 -35.46541 -1.07672  1.000 43.49542  ? 403 ARG B O   1 
ATOM   891  C CB  . ARG B 2 71  ? 25.64897 -34.81706 2.12843   1.000 41.27748  ? 403 ARG B CB  1 
ATOM   892  C CG  . ARG B 2 71  ? 26.37716 -34.41126 3.39268   1.000 39.04915  ? 403 ARG B CG  1 
ATOM   893  C CD  . ARG B 2 71  ? 25.50861 -33.49074 4.23668   1.000 43.58992  ? 403 ARG B CD  1 
ATOM   894  N NE  . ARG B 2 71  ? 24.10668 -33.89119 4.23052   1.000 44.77956  ? 403 ARG B NE  1 
ATOM   895  C CZ  . ARG B 2 71  ? 23.12763 -33.19443 4.79066   1.000 40.26937  ? 403 ARG B CZ  1 
ATOM   896  N NH1 . ARG B 2 71  ? 23.36384 -32.05741 5.42545   1.000 43.02435  ? 403 ARG B NH1 1 
ATOM   897  N NH2 . ARG B 2 71  ? 21.88008 -33.64677 4.70825   1.000 36.17905  ? 403 ARG B NH2 1 
ATOM   898  N N   . GLY B 2 72  ? 25.45679 -37.29755 0.22871   1.000 45.69814  ? 404 GLY B N   1 
ATOM   899  C CA  . GLY B 2 72  ? 24.55036 -38.06154 -0.61084  1.000 44.20835  ? 404 GLY B CA  1 
ATOM   900  C C   . GLY B 2 72  ? 23.15329 -37.47595 -0.64728  1.000 49.88621  ? 404 GLY B C   1 
ATOM   901  O O   . GLY B 2 72  ? 22.47257 -37.54705 -1.67502  1.000 49.49010  ? 404 GLY B O   1 
ATOM   902  N N   . ASP B 2 73  ? 22.71146 -36.88276 0.46711   1.000 46.66323  ? 405 ASP B N   1 
ATOM   903  C CA  . ASP B 2 73  ? 21.41223 -36.21796 0.50590   1.000 50.69731  ? 405 ASP B CA  1 
ATOM   904  C C   . ASP B 2 73  ? 21.31651 -35.09564 -0.51646  1.000 43.92693  ? 405 ASP B C   1 
ATOM   905  O O   . ASP B 2 73  ? 20.22341 -34.79806 -1.01055  1.000 44.55966  ? 405 ASP B O   1 
ATOM   906  C CB  . ASP B 2 73  ? 21.14987 -35.64812 1.90311   1.000 49.62397  ? 405 ASP B CB  1 
ATOM   907  C CG  . ASP B 2 73  ? 20.93993 -36.72079 2.94399   1.000 56.27256  ? 405 ASP B CG  1 
ATOM   908  O OD1 . ASP B 2 73  ? 20.47676 -37.82172 2.57967   1.000 67.57758  ? 405 ASP B OD1 1 
ATOM   909  O OD2 . ASP B 2 73  ? 21.23008 -36.45827 4.13024   1.000 53.78219  ? 405 ASP B OD2 1 
ATOM   910  N N   . GLU B 2 74  ? 22.43904 -34.45988 -0.83851  1.000 39.45827  ? 406 GLU B N   1 
ATOM   911  C CA  . GLU B 2 74  ? 22.44269 -33.21709 -1.59387  1.000 44.25571  ? 406 GLU B CA  1 
ATOM   912  C C   . GLU B 2 74  ? 22.75015 -33.40344 -3.07476  1.000 41.53567  ? 406 GLU B C   1 
ATOM   913  O O   . GLU B 2 74  ? 22.78018 -32.41331 -3.81137  1.000 40.23369  ? 406 GLU B O   1 
ATOM   914  C CB  . GLU B 2 74  ? 23.44388 -32.24358 -0.96627  1.000 42.46103  ? 406 GLU B CB  1 
ATOM   915  C CG  . GLU B 2 74  ? 23.08931 -31.86864 0.46630   1.000 42.03797  ? 406 GLU B CG  1 
ATOM   916  C CD  . GLU B 2 74  ? 24.27207 -31.34412 1.25333   1.000 39.68865  ? 406 GLU B CD  1 
ATOM   917  O OE1 . GLU B 2 74  ? 25.42349 -31.65389 0.88237   1.000 39.55363  ? 406 GLU B OE1 1 
ATOM   918  O OE2 . GLU B 2 74  ? 24.04837 -30.62200 2.24703   1.000 43.99961  ? 406 GLU B OE2 1 
ATOM   919  N N   . VAL B 2 75  ? 22.97210 -34.63969 -3.53027  1.000 38.99417  ? 407 VAL B N   1 
ATOM   920  C CA  . VAL B 2 75  ? 23.21798 -34.86886 -4.95158  1.000 43.09181  ? 407 VAL B CA  1 
ATOM   921  C C   . VAL B 2 75  ? 21.97817 -34.53556 -5.77347  1.000 40.35987  ? 407 VAL B C   1 
ATOM   922  O O   . VAL B 2 75  ? 22.08738 -34.08786 -6.92229  1.000 48.01358  ? 407 VAL B O   1 
ATOM   923  C CB  . VAL B 2 75  ? 23.68340 -36.31887 -5.18770  1.000 41.79490  ? 407 VAL B CB  1 
ATOM   924  C CG1 . VAL B 2 75  ? 23.92106 -36.57482 -6.67103  1.000 40.43837  ? 407 VAL B CG1 1 
ATOM   925  C CG2 . VAL B 2 75  ? 24.94618 -36.60698 -4.39108  1.000 38.71818  ? 407 VAL B CG2 1 
ATOM   926  N N   . ARG B 2 76  ? 20.78712 -34.72443 -5.19890  1.000 39.79244  ? 408 ARG B N   1 
ATOM   927  C CA  . ARG B 2 76  ? 19.55132 -34.41531 -5.91048  1.000 40.51190  ? 408 ARG B CA  1 
ATOM   928  C C   . ARG B 2 76  ? 19.46869 -32.94077 -6.28898  1.000 47.11617  ? 408 ARG B C   1 
ATOM   929  O O   . ARG B 2 76  ? 18.83003 -32.59166 -7.28924  1.000 44.65709  ? 408 ARG B O   1 
ATOM   930  C CB  . ARG B 2 76  ? 18.34554 -34.81350 -5.05573  1.000 47.82736  ? 408 ARG B CB  1 
ATOM   931  C CG  . ARG B 2 76  ? 18.12833 -33.92396 -3.83684  1.000 47.78814  ? 408 ARG B CG  1 
ATOM   932  C CD  . ARG B 2 76  ? 17.23454 -34.58031 -2.79681  1.000 57.73045  ? 408 ARG B CD  1 
ATOM   933  N NE  . ARG B 2 76  ? 17.87843 -35.73309 -2.17760  1.000 60.17449  ? 408 ARG B NE  1 
ATOM   934  C CZ  . ARG B 2 76  ? 17.47082 -36.30599 -1.05324  1.000 64.54467  ? 408 ARG B CZ  1 
ATOM   935  N NH1 . ARG B 2 76  ? 16.42553 -35.84822 -0.38347  1.000 69.51359  ? 408 ARG B NH1 1 
ATOM   936  N NH2 . ARG B 2 76  ? 18.13171 -37.36179 -0.58623  1.000 68.40632  ? 408 ARG B NH2 1 
ATOM   937  N N   . GLN B 2 77  ? 20.10941 -32.06359 -5.51350  1.000 44.45944  ? 409 GLN B N   1 
ATOM   938  C CA  . GLN B 2 77  ? 20.05195 -30.63469 -5.79184  1.000 44.19842  ? 409 GLN B CA  1 
ATOM   939  C C   . GLN B 2 77  ? 20.93798 -30.22758 -6.96197  1.000 40.57931  ? 409 GLN B C   1 
ATOM   940  O O   . GLN B 2 77  ? 20.74573 -29.14041 -7.51583  1.000 43.34992  ? 409 GLN B O   1 
ATOM   941  C CB  . GLN B 2 77  ? 20.43891 -29.83977 -4.54017  1.000 45.86396  ? 409 GLN B CB  1 
ATOM   942  C CG  . GLN B 2 77  ? 19.56354 -30.13865 -3.32611  1.000 47.07830  ? 409 GLN B CG  1 
ATOM   943  C CD  . GLN B 2 77  ? 19.94983 -29.33477 -2.09560  1.000 43.45183  ? 409 GLN B CD  1 
ATOM   944  O OE1 . GLN B 2 77  ? 20.66328 -28.33533 -2.18514  1.000 44.01677  ? 409 GLN B OE1 1 
ATOM   945  N NE2 . GLN B 2 77  ? 19.47740 -29.77297 -0.93592  1.000 42.92939  ? 409 GLN B NE2 1 
ATOM   946  N N   . ILE B 2 78  ? 21.89825 -31.06575 -7.34969  1.000 38.36434  ? 410 ILE B N   1 
ATOM   947  C CA  . ILE B 2 78  ? 22.74046 -30.78176 -8.50637  1.000 44.20381  ? 410 ILE B CA  1 
ATOM   948  C C   . ILE B 2 78  ? 21.96048 -31.14725 -9.76319  1.000 45.14692  ? 410 ILE B C   1 
ATOM   949  O O   . ILE B 2 78  ? 22.28830 -32.11347 -10.46195 1.000 43.24944  ? 410 ILE B O   1 
ATOM   950  C CB  . ILE B 2 78  ? 24.07949 -31.53781 -8.43086  1.000 44.06625  ? 410 ILE B CB  1 
ATOM   951  C CG1 . ILE B 2 78  ? 24.68526 -31.40684 -7.03259  1.000 38.77679  ? 410 ILE B CG1 1 
ATOM   952  C CG2 . ILE B 2 78  ? 25.05483 -30.99834 -9.46252  1.000 39.00777  ? 410 ILE B CG2 1 
ATOM   953  C CD1 . ILE B 2 78  ? 25.00975 -29.98247 -6.64358  1.000 38.12177  ? 410 ILE B CD1 1 
ATOM   954  N N   . ALA B 2 79  ? 20.91645 -30.37818 -10.04893 1.000 40.70746  ? 411 ALA B N   1 
ATOM   955  C CA  . ALA B 2 79  ? 20.01631 -30.65344 -11.15638 1.000 44.51343  ? 411 ALA B CA  1 
ATOM   956  C C   . ALA B 2 79  ? 19.27392 -29.37036 -11.48960 1.000 46.27156  ? 411 ALA B C   1 
ATOM   957  O O   . ALA B 2 79  ? 19.15565 -28.48146 -10.63726 1.000 43.90278  ? 411 ALA B O   1 
ATOM   958  C CB  . ALA B 2 79  ? 19.02915 -31.77935 -10.80505 1.000 43.04805  ? 411 ALA B CB  1 
ATOM   959  N N   . PRO B 2 80  ? 18.78125 -29.23235 -12.71908 1.000 41.44023  ? 412 PRO B N   1 
ATOM   960  C CA  . PRO B 2 80  ? 18.02731 -28.02411 -13.07049 1.000 45.38794  ? 412 PRO B CA  1 
ATOM   961  C C   . PRO B 2 80  ? 16.74347 -27.91773 -12.26175 1.000 47.22730  ? 412 PRO B C   1 
ATOM   962  O O   . PRO B 2 80  ? 16.05773 -28.91137 -12.01382 1.000 47.95000  ? 412 PRO B O   1 
ATOM   963  C CB  . PRO B 2 80  ? 17.73811 -28.20662 -14.56531 1.000 46.55033  ? 412 PRO B CB  1 
ATOM   964  C CG  . PRO B 2 80  ? 18.77517 -29.17508 -15.03951 1.000 43.80044  ? 412 PRO B CG  1 
ATOM   965  C CD  . PRO B 2 80  ? 19.01470 -30.09805 -13.88743 1.000 44.16006  ? 412 PRO B CD  1 
ATOM   966  N N   . GLY B 2 81  ? 16.42914 -26.69551 -11.84549 1.000 49.16450  ? 413 GLY B N   1 
ATOM   967  C CA  . GLY B 2 81  ? 15.19352 -26.42835 -11.12771 1.000 52.16096  ? 413 GLY B CA  1 
ATOM   968  C C   . GLY B 2 81  ? 15.13440 -26.97612 -9.71781  1.000 52.90018  ? 413 GLY B C   1 
ATOM   969  O O   . GLY B 2 81  ? 14.07008 -27.43126 -9.27896  1.000 62.81794  ? 413 GLY B O   1 
ATOM   970  N N   . GLN B 2 82  ? 16.24584 -26.93370 -8.99043  1.000 51.44456  ? 414 GLN B N   1 
ATOM   971  C CA  . GLN B 2 82  ? 16.31563 -27.45672 -7.63573  1.000 48.49590  ? 414 GLN B CA  1 
ATOM   972  C C   . GLN B 2 82  ? 16.59051 -26.32971 -6.65094  1.000 44.93936  ? 414 GLN B C   1 
ATOM   973  O O   . GLN B 2 82  ? 17.20176 -25.31484 -6.99722  1.000 42.24072  ? 414 GLN B O   1 
ATOM   974  C CB  . GLN B 2 82  ? 17.40341 -28.53206 -7.51319  1.000 47.42895  ? 414 GLN B CB  1 
ATOM   975  C CG  . GLN B 2 82  ? 17.17416 -29.74878 -8.39882  1.000 50.34526  ? 414 GLN B CG  1 
ATOM   976  C CD  . GLN B 2 82  ? 15.91433 -30.50719 -8.02946  1.000 56.17928  ? 414 GLN B CD  1 
ATOM   977  O OE1 . GLN B 2 82  ? 15.52129 -30.54932 -6.86241  1.000 58.72421  ? 414 GLN B OE1 1 
ATOM   978  N NE2 . GLN B 2 82  ? 15.26993 -31.10646 -9.02479  1.000 51.29372  ? 414 GLN B NE2 1 
ATOM   979  N N   . THR B 2 83  ? 16.11938 -26.51622 -5.42168  1.000 50.37096  ? 415 THR B N   1 
ATOM   980  C CA  . THR B 2 83  ? 16.40253 -25.62200 -4.31068  1.000 47.01655  ? 415 THR B CA  1 
ATOM   981  C C   . THR B 2 83  ? 17.05181 -26.41189 -3.18169  1.000 48.34420  ? 415 THR B C   1 
ATOM   982  O O   . THR B 2 83  ? 17.10526 -27.64524 -3.19748  1.000 52.64906  ? 415 THR B O   1 
ATOM   983  C CB  . THR B 2 83  ? 15.13170 -24.92396 -3.80617  1.000 48.07827  ? 415 THR B CB  1 
ATOM   984  O OG1 . THR B 2 83  ? 14.07850 -25.88525 -3.66990  1.000 57.06054  ? 415 THR B OG1 1 
ATOM   985  C CG2 . THR B 2 83  ? 14.69704 -23.82724 -4.76778  1.000 50.40097  ? 415 THR B CG2 1 
ATOM   986  N N   . GLY B 2 84  ? 17.55639 -25.68015 -2.19527  1.000 41.17142  ? 416 GLY B N   1 
ATOM   987  C CA  . GLY B 2 84  ? 18.24884 -26.29705 -1.08535  1.000 40.99949  ? 416 GLY B CA  1 
ATOM   988  C C   . GLY B 2 84  ? 19.51572 -25.55027 -0.72365  1.000 44.52792  ? 416 GLY B C   1 
ATOM   989  O O   . GLY B 2 84  ? 19.90870 -24.60132 -1.41032  1.000 44.28645  ? 416 GLY B O   1 
ATOM   990  N N   . LYS B 2 85  ? 20.16304 -25.97482 0.36250   1.000 44.12260  ? 417 LYS B N   1 
ATOM   991  C CA  . LYS B 2 85  ? 21.37819 -25.30720 0.81973   1.000 42.19836  ? 417 LYS B CA  1 
ATOM   992  C C   . LYS B 2 85  ? 22.44257 -25.28435 -0.27163  1.000 42.37122  ? 417 LYS B C   1 
ATOM   993  O O   . LYS B 2 85  ? 23.11099 -24.26434 -0.48261  1.000 39.38095  ? 417 LYS B O   1 
ATOM   994  C CB  . LYS B 2 85  ? 21.90391 -26.00738 2.07353   1.000 41.38584  ? 417 LYS B CB  1 
ATOM   995  C CG  . LYS B 2 85  ? 22.94960 -25.23251 2.84464   1.000 41.57419  ? 417 LYS B CG  1 
ATOM   996  C CD  . LYS B 2 85  ? 23.56482 -26.10505 3.92445   1.000 43.52004  ? 417 LYS B CD  1 
ATOM   997  C CE  . LYS B 2 85  ? 22.49738 -26.82251 4.73458   1.000 39.56380  ? 417 LYS B CE  1 
ATOM   998  N NZ  . LYS B 2 85  ? 23.07648 -27.82620 5.66706   1.000 36.29106  ? 417 LYS B NZ  1 
ATOM   999  N N   . ILE B 2 86  ? 22.59499 -26.39286 -0.99158  1.000 39.14258  ? 418 ILE B N   1 
ATOM   1000 C CA  . ILE B 2 86  ? 23.63412 -26.48885 -2.00835  1.000 45.19686  ? 418 ILE B CA  1 
ATOM   1001 C C   . ILE B 2 86  ? 23.21678 -25.76084 -3.27920  1.000 44.93189  ? 418 ILE B C   1 
ATOM   1002 O O   . ILE B 2 86  ? 23.98310 -24.96829 -3.83733  1.000 44.47892  ? 418 ILE B O   1 
ATOM   1003 C CB  . ILE B 2 86  ? 23.96239 -27.96619 -2.28622  1.000 46.24216  ? 418 ILE B CB  1 
ATOM   1004 C CG1 . ILE B 2 86  ? 24.31678 -28.67911 -0.98095  1.000 39.36109  ? 418 ILE B CG1 1 
ATOM   1005 C CG2 . ILE B 2 86  ? 25.09738 -28.08064 -3.29504  1.000 41.23019  ? 418 ILE B CG2 1 
ATOM   1006 C CD1 . ILE B 2 86  ? 25.47503 -28.05089 -0.24482  1.000 42.60413  ? 418 ILE B CD1 1 
ATOM   1007 N N   . ALA B 2 87  ? 21.99439 -26.01381 -3.75136  1.000 41.50607  ? 419 ALA B N   1 
ATOM   1008 C CA  . ALA B 2 87  ? 21.54319 -25.41281 -5.00070  1.000 42.44751  ? 419 ALA B CA  1 
ATOM   1009 C C   . ALA B 2 87  ? 21.40543 -23.89928 -4.89078  1.000 44.41128  ? 419 ALA B C   1 
ATOM   1010 O O   . ALA B 2 87  ? 21.54677 -23.19265 -5.89575  1.000 44.23672  ? 419 ALA B O   1 
ATOM   1011 C CB  . ALA B 2 87  ? 20.21647 -26.03670 -5.43106  1.000 41.99704  ? 419 ALA B CB  1 
ATOM   1012 N N   . ASP B 2 88  ? 21.13963 -23.38248 -3.69217  1.000 43.89880  ? 420 ASP B N   1 
ATOM   1013 C CA  . ASP B 2 88  ? 20.92528 -21.95110 -3.52140  1.000 42.36554  ? 420 ASP B CA  1 
ATOM   1014 C C   . ASP B 2 88  ? 22.19889 -21.18986 -3.18302  1.000 40.65973  ? 420 ASP B C   1 
ATOM   1015 O O   . ASP B 2 88  ? 22.33529 -20.02663 -3.57861  1.000 45.16176  ? 420 ASP B O   1 
ATOM   1016 C CB  . ASP B 2 88  ? 19.88304 -21.69740 -2.42611  1.000 41.36999  ? 420 ASP B CB  1 
ATOM   1017 C CG  . ASP B 2 88  ? 18.50883 -22.22961 -2.79162  1.000 47.81062  ? 420 ASP B CG  1 
ATOM   1018 O OD1 . ASP B 2 88  ? 18.28529 -22.55349 -3.97738  1.000 48.70820  ? 420 ASP B OD1 1 
ATOM   1019 O OD2 . ASP B 2 88  ? 17.65152 -22.32715 -1.89147  1.000 45.53024  ? 420 ASP B OD2 1 
ATOM   1020 N N   . TYR B 2 89  ? 23.13297 -21.80793 -2.45689  1.000 44.48678  ? 421 TYR B N   1 
ATOM   1021 C CA  . TYR B 2 89  ? 24.28364 -21.09671 -1.91811  1.000 44.02776  ? 421 TYR B CA  1 
ATOM   1022 C C   . TYR B 2 89  ? 25.62997 -21.62995 -2.39047  1.000 39.01454  ? 421 TYR B C   1 
ATOM   1023 O O   . TYR B 2 89  ? 26.65069 -20.97999 -2.13603  1.000 35.55843  ? 421 TYR B O   1 
ATOM   1024 C CB  . TYR B 2 89  ? 24.26199 -21.12748 -0.37810  1.000 39.69513  ? 421 TYR B CB  1 
ATOM   1025 C CG  . TYR B 2 89  ? 23.04907 -20.47722 0.26158   1.000 41.55199  ? 421 TYR B CG  1 
ATOM   1026 C CD1 . TYR B 2 89  ? 22.27341 -19.56043 -0.43573  1.000 42.52841  ? 421 TYR B CD1 1 
ATOM   1027 C CD2 . TYR B 2 89  ? 22.68681 -20.77591 1.57162   1.000 39.64476  ? 421 TYR B CD2 1 
ATOM   1028 C CE1 . TYR B 2 89  ? 21.16864 -18.96754 0.14311   1.000 42.57878  ? 421 TYR B CE1 1 
ATOM   1029 C CE2 . TYR B 2 89  ? 21.58159 -20.18511 2.16124   1.000 40.64121  ? 421 TYR B CE2 1 
ATOM   1030 C CZ  . TYR B 2 89  ? 20.82796 -19.28115 1.44194   1.000 45.78615  ? 421 TYR B CZ  1 
ATOM   1031 O OH  . TYR B 2 89  ? 19.72858 -18.68730 2.01607   1.000 40.95346  ? 421 TYR B OH  1 
ATOM   1032 N N   . ASN B 2 90  ? 25.67311 -22.77492 -3.06841  1.000 36.84305  ? 422 ASN B N   1 
ATOM   1033 C CA  . ASN B 2 90  ? 26.94417 -23.41770 -3.38145  1.000 36.98463  ? 422 ASN B CA  1 
ATOM   1034 C C   . ASN B 2 90  ? 27.14723 -23.66871 -4.86560  1.000 40.93753  ? 422 ASN B C   1 
ATOM   1035 O O   . ASN B 2 90  ? 28.17327 -23.25400 -5.42097  1.000 37.09262  ? 422 ASN B O   1 
ATOM   1036 C CB  . ASN B 2 90  ? 27.06055 -24.73107 -2.60142  1.000 37.14574  ? 422 ASN B CB  1 
ATOM   1037 C CG  . ASN B 2 90  ? 27.14612 -24.50568 -1.10960  1.000 38.08718  ? 422 ASN B CG  1 
ATOM   1038 O OD1 . ASN B 2 90  ? 28.22432 -24.25696 -0.57431  1.000 36.09188  ? 422 ASN B OD1 1 
ATOM   1039 N ND2 . ASN B 2 90  ? 26.00486 -24.57533 -0.43028  1.000 36.94482  ? 422 ASN B ND2 1 
ATOM   1040 N N   . TYR B 2 91  ? 26.20686 -24.33894 -5.53292  1.000 40.67257  ? 423 TYR B N   1 
ATOM   1041 C CA  . TYR B 2 91  ? 26.35658 -24.65572 -6.95021  1.000 38.31893  ? 423 TYR B CA  1 
ATOM   1042 C C   . TYR B 2 91  ? 24.97871 -24.71681 -7.59019  1.000 41.65486  ? 423 TYR B C   1 
ATOM   1043 O O   . TYR B 2 91  ? 24.16577 -25.57482 -7.23325  1.000 42.25780  ? 423 TYR B O   1 
ATOM   1044 C CB  . TYR B 2 91  ? 27.10532 -25.97665 -7.14179  1.000 38.58637  ? 423 TYR B CB  1 
ATOM   1045 C CG  . TYR B 2 91  ? 27.41461 -26.29713 -8.58808  1.000 39.40265  ? 423 TYR B CG  1 
ATOM   1046 C CD1 . TYR B 2 91  ? 28.50619 -25.72466 -9.22906  1.000 42.02644  ? 423 TYR B CD1 1 
ATOM   1047 C CD2 . TYR B 2 91  ? 26.61842 -27.17529 -9.31111  1.000 41.22069  ? 423 TYR B CD2 1 
ATOM   1048 C CE1 . TYR B 2 91  ? 28.79428 -26.01571 -10.55197 1.000 37.12654  ? 423 TYR B CE1 1 
ATOM   1049 C CE2 . TYR B 2 91  ? 26.89654 -27.47284 -10.63381 1.000 37.89815  ? 423 TYR B CE2 1 
ATOM   1050 C CZ  . TYR B 2 91  ? 27.98546 -26.89124 -11.25115 1.000 41.85135  ? 423 TYR B CZ  1 
ATOM   1051 O OH  . TYR B 2 91  ? 28.26552 -27.18662 -12.57070 1.000 43.94343  ? 423 TYR B OH  1 
ATOM   1052 N N   . LYS B 2 92  ? 24.72440 -23.82011 -8.53987  1.000 35.75635  ? 424 LYS B N   1 
ATOM   1053 C CA  . LYS B 2 92  ? 23.41426 -23.67529 -9.15892  1.000 36.87787  ? 424 LYS B CA  1 
ATOM   1054 C C   . LYS B 2 92  ? 23.49723 -24.00458 -10.64367 1.000 42.05710  ? 424 LYS B C   1 
ATOM   1055 O O   . LYS B 2 92  ? 24.35236 -23.46901 -11.35702 1.000 38.84522  ? 424 LYS B O   1 
ATOM   1056 C CB  . LYS B 2 92  ? 22.87656 -22.25532 -8.96323  1.000 34.53975  ? 424 LYS B CB  1 
ATOM   1057 C CG  . LYS B 2 92  ? 21.50737 -22.01641 -9.57109  1.000 38.43126  ? 424 LYS B CG  1 
ATOM   1058 C CD  . LYS B 2 92  ? 20.48515 -23.00123 -9.02537  1.000 37.00663  ? 424 LYS B CD  1 
ATOM   1059 C CE  . LYS B 2 92  ? 19.08703 -22.69594 -9.53395  1.000 34.29089  ? 424 LYS B CE  1 
ATOM   1060 N NZ  . LYS B 2 92  ? 18.12279 -23.74913 -9.11342  1.000 41.55300  ? 424 LYS B NZ  1 
ATOM   1061 N N   . LEU B 2 93  ? 22.60407 -24.88144 -11.10386 1.000 38.92849  ? 425 LEU B N   1 
ATOM   1062 C CA  . LEU B 2 93  ? 22.44068 -25.24719 -12.50280 1.000 39.75559  ? 425 LEU B CA  1 
ATOM   1063 C C   . LEU B 2 93  ? 21.27469 -24.48475 -13.11852 1.000 45.21372  ? 425 LEU B C   1 
ATOM   1064 O O   . LEU B 2 93  ? 20.23462 -24.31360 -12.47273 1.000 38.23929  ? 425 LEU B O   1 
ATOM   1065 C CB  . LEU B 2 93  ? 22.19720 -26.74978 -12.65516 1.000 37.06833  ? 425 LEU B CB  1 
ATOM   1066 C CG  . LEU B 2 93  ? 23.41695 -27.66595 -12.53330 1.000 35.53894  ? 425 LEU B CG  1 
ATOM   1067 C CD1 . LEU B 2 93  ? 23.04863 -29.10078 -12.87575 1.000 33.69094  ? 425 LEU B CD1 1 
ATOM   1068 C CD2 . LEU B 2 93  ? 24.55162 -27.17724 -13.42136 1.000 39.37891  ? 425 LEU B CD2 1 
ATOM   1069 N N   . PRO B 2 94  ? 21.42180 -24.01732 -14.35610 1.000 48.86038  ? 426 PRO B N   1 
ATOM   1070 C CA  . PRO B 2 94  ? 20.34577 -23.24940 -14.99368 1.000 47.43460  ? 426 PRO B CA  1 
ATOM   1071 C C   . PRO B 2 94  ? 19.19742 -24.14761 -15.43080 1.000 47.83793  ? 426 PRO B C   1 
ATOM   1072 O O   . PRO B 2 94  ? 19.30793 -25.37313 -15.49923 1.000 47.82519  ? 426 PRO B O   1 
ATOM   1073 C CB  . PRO B 2 94  ? 21.03936 -22.60550 -16.19647 1.000 39.53679  ? 426 PRO B CB  1 
ATOM   1074 C CG  . PRO B 2 94  ? 22.13804 -23.55476 -16.53369 1.000 38.78305  ? 426 PRO B CG  1 
ATOM   1075 C CD  . PRO B 2 94  ? 22.60890 -24.13183 -15.22149 1.000 43.88506  ? 426 PRO B CD  1 
ATOM   1076 N N   . ASP B 2 95  ? 18.06656 -23.50308 -15.73004 1.000 49.72669  ? 427 ASP B N   1 
ATOM   1077 C CA  . ASP B 2 95  ? 16.90643 -24.23855 -16.22417 1.000 51.78410  ? 427 ASP B CA  1 
ATOM   1078 C C   . ASP B 2 95  ? 17.20258 -24.89935 -17.56421 1.000 47.20830  ? 427 ASP B C   1 
ATOM   1079 O O   . ASP B 2 95  ? 16.87568 -26.07375 -17.77299 1.000 52.01974  ? 427 ASP B O   1 
ATOM   1080 C CB  . ASP B 2 95  ? 15.70217 -23.30431 -16.34664 1.000 50.61939  ? 427 ASP B CB  1 
ATOM   1081 C CG  . ASP B 2 95  ? 15.27675 -22.72391 -15.01477 1.000 54.28237  ? 427 ASP B CG  1 
ATOM   1082 O OD1 . ASP B 2 95  ? 15.51820 -23.37683 -13.97737 1.000 55.08478  ? 427 ASP B OD1 1 
ATOM   1083 O OD2 . ASP B 2 95  ? 14.70067 -21.61490 -15.00571 1.000 61.66445  ? 427 ASP B OD2 1 
ATOM   1084 N N   . ASP B 2 96  ? 17.82585 -24.16168 -18.48491 1.000 45.69416  ? 428 ASP B N   1 
ATOM   1085 C CA  . ASP B 2 96  ? 18.14866 -24.66861 -19.81353 1.000 47.45951  ? 428 ASP B CA  1 
ATOM   1086 C C   . ASP B 2 96  ? 19.48668 -25.39712 -19.85397 1.000 46.13408  ? 428 ASP B C   1 
ATOM   1087 O O   . ASP B 2 96  ? 20.18749 -25.34377 -20.87315 1.000 52.49120  ? 428 ASP B O   1 
ATOM   1088 C CB  . ASP B 2 96  ? 18.13424 -23.52370 -20.82782 1.000 39.97312  ? 428 ASP B CB  1 
ATOM   1089 C CG  . ASP B 2 96  ? 19.19333 -22.47690 -20.54121 1.000 47.14011  ? 428 ASP B CG  1 
ATOM   1090 O OD1 . ASP B 2 96  ? 19.56817 -22.31229 -19.36018 1.000 50.72251  ? 428 ASP B OD1 1 
ATOM   1091 O OD2 . ASP B 2 96  ? 19.65420 -21.81893 -21.49851 1.000 55.79032  ? 428 ASP B OD2 1 
ATOM   1092 N N   . PHE B 2 97  ? 19.85286 -26.08362 -18.77504 1.000 44.86476  ? 429 PHE B N   1 
ATOM   1093 C CA  . PHE B 2 97  ? 21.15208 -26.73649 -18.69551 1.000 44.81169  ? 429 PHE B CA  1 
ATOM   1094 C C   . PHE B 2 97  ? 21.23988 -27.91391 -19.65837 1.000 44.82877  ? 429 PHE B C   1 
ATOM   1095 O O   . PHE B 2 97  ? 20.32054 -28.73170 -19.75636 1.000 44.14933  ? 429 PHE B O   1 
ATOM   1096 C CB  . PHE B 2 97  ? 21.41780 -27.20937 -17.26541 1.000 43.75017  ? 429 PHE B CB  1 
ATOM   1097 C CG  . PHE B 2 97  ? 22.58359 -28.15131 -17.14033 1.000 43.42467  ? 429 PHE B CG  1 
ATOM   1098 C CD1 . PHE B 2 97  ? 23.88416 -27.68159 -17.22254 1.000 40.87685  ? 429 PHE B CD1 1 
ATOM   1099 C CD2 . PHE B 2 97  ? 22.37807 -29.50546 -16.92305 1.000 46.21712  ? 429 PHE B CD2 1 
ATOM   1100 C CE1 . PHE B 2 97  ? 24.95768 -28.54352 -17.10118 1.000 38.74432  ? 429 PHE B CE1 1 
ATOM   1101 C CE2 . PHE B 2 97  ? 23.44853 -30.37354 -16.79849 1.000 44.12763  ? 429 PHE B CE2 1 
ATOM   1102 C CZ  . PHE B 2 97  ? 24.74010 -29.89085 -16.88861 1.000 43.56060  ? 429 PHE B CZ  1 
ATOM   1103 N N   . THR B 2 98  ? 22.36381 -27.99579 -20.36652 1.000 39.10500  ? 430 THR B N   1 
ATOM   1104 C CA  . THR B 2 98  ? 22.67039 -29.11025 -21.25257 1.000 43.30969  ? 430 THR B CA  1 
ATOM   1105 C C   . THR B 2 98  ? 23.97783 -29.73714 -20.79150 1.000 44.87482  ? 430 THR B C   1 
ATOM   1106 O O   . THR B 2 98  ? 25.01898 -29.06939 -20.77576 1.000 44.99813  ? 430 THR B O   1 
ATOM   1107 C CB  . THR B 2 98  ? 22.77192 -28.65229 -22.71087 1.000 41.57220  ? 430 THR B CB  1 
ATOM   1108 O OG1 . THR B 2 98  ? 21.51722 -28.10224 -23.12972 1.000 36.93413  ? 430 THR B OG1 1 
ATOM   1109 C CG2 . THR B 2 98  ? 23.12742 -29.82349 -23.61217 1.000 37.33973  ? 430 THR B CG2 1 
ATOM   1110 N N   . GLY B 2 99  ? 23.92207 -31.00519 -20.41807 1.000 44.93326  ? 431 GLY B N   1 
ATOM   1111 C CA  . GLY B 2 99  ? 25.08517 -31.70690 -19.92098 1.000 41.71630  ? 431 GLY B CA  1 
ATOM   1112 C C   . GLY B 2 99  ? 24.65738 -32.83073 -18.99871 1.000 43.57869  ? 431 GLY B C   1 
ATOM   1113 O O   . GLY B 2 99  ? 23.48388 -33.18065 -18.92055 1.000 46.48910  ? 431 GLY B O   1 
ATOM   1114 N N   . CYS B 2 100 ? 25.63840 -33.38600 -18.28957 1.000 39.72110  ? 432 CYS B N   1 
ATOM   1115 C CA  . CYS B 2 100 ? 25.41227 -34.53151 -17.42090 1.000 42.82310  ? 432 CYS B CA  1 
ATOM   1116 C C   . CYS B 2 100 ? 25.94774 -34.25787 -16.02229 1.000 43.79566  ? 432 CYS B C   1 
ATOM   1117 O O   . CYS B 2 100 ? 26.89047 -33.48357 -15.83566 1.000 43.83775  ? 432 CYS B O   1 
ATOM   1118 C CB  . CYS B 2 100 ? 26.07154 -35.79823 -17.97805 1.000 40.01504  ? 432 CYS B CB  1 
ATOM   1119 S SG  . CYS B 2 100 ? 25.51598 -36.26254 -19.63326 1.000 58.54770  ? 432 CYS B SG  1 
ATOM   1120 N N   . VAL B 2 101 ? 25.33181 -34.90799 -15.03937 1.000 42.40442  ? 433 VAL B N   1 
ATOM   1121 C CA  . VAL B 2 101 ? 25.75874 -34.84349 -13.64653 1.000 43.06297  ? 433 VAL B CA  1 
ATOM   1122 C C   . VAL B 2 101 ? 26.12541 -36.25450 -13.21519 1.000 45.84903  ? 433 VAL B C   1 
ATOM   1123 O O   . VAL B 2 101 ? 25.26985 -37.14819 -13.20624 1.000 51.02294  ? 433 VAL B O   1 
ATOM   1124 C CB  . VAL B 2 101 ? 24.67007 -34.25585 -12.73418 1.000 42.52887  ? 433 VAL B CB  1 
ATOM   1125 C CG1 . VAL B 2 101 ? 25.11701 -34.30088 -11.28287 1.000 42.90782  ? 433 VAL B CG1 1 
ATOM   1126 C CG2 . VAL B 2 101 ? 24.33810 -32.82975 -13.14828 1.000 41.64882  ? 433 VAL B CG2 1 
ATOM   1127 N N   . ILE B 2 102 ? 27.39079 -36.45568 -12.86130 1.000 43.37685  ? 434 ILE B N   1 
ATOM   1128 C CA  . ILE B 2 102 ? 27.91182 -37.76556 -12.49373 1.000 44.22988  ? 434 ILE B CA  1 
ATOM   1129 C C   . ILE B 2 102 ? 28.39705 -37.70193 -11.05152 1.000 41.77691  ? 434 ILE B C   1 
ATOM   1130 O O   . ILE B 2 102 ? 29.14210 -36.78714 -10.68190 1.000 41.79369  ? 434 ILE B O   1 
ATOM   1131 C CB  . ILE B 2 102 ? 29.04226 -38.20257 -13.44208 1.000 43.91653  ? 434 ILE B CB  1 
ATOM   1132 C CG1 . ILE B 2 102 ? 28.61629 -37.98694 -14.89713 1.000 47.11786  ? 434 ILE B CG1 1 
ATOM   1133 C CG2 . ILE B 2 102 ? 29.40437 -39.65811 -13.20444 1.000 50.31661  ? 434 ILE B CG2 1 
ATOM   1134 C CD1 . ILE B 2 102 ? 29.73678 -38.14953 -15.89755 1.000 46.98126  ? 434 ILE B CD1 1 
ATOM   1135 N N   . ALA B 2 103 ? 27.97503 -38.66933 -10.23965 1.000 42.45940  ? 435 ALA B N   1 
ATOM   1136 C CA  . ALA B 2 103 ? 28.34229 -38.69898 -8.83178  1.000 47.47627  ? 435 ALA B CA  1 
ATOM   1137 C C   . ALA B 2 103 ? 28.55001 -40.13823 -8.38543  1.000 48.37121  ? 435 ALA B C   1 
ATOM   1138 O O   . ALA B 2 103 ? 27.99742 -41.07746 -8.96260  1.000 50.76997  ? 435 ALA B O   1 
ATOM   1139 C CB  . ALA B 2 103 ? 27.28225 -38.02025 -7.95266  1.000 41.05891  ? 435 ALA B CB  1 
ATOM   1140 N N   . TRP B 2 104 ? 29.35734 -40.29828 -7.33965  1.000 49.48532  ? 436 TRP B N   1 
ATOM   1141 C CA  . TRP B 2 104 ? 29.62598 -41.61484 -6.78058  1.000 51.06128  ? 436 TRP B CA  1 
ATOM   1142 C C   . TRP B 2 104 ? 30.04134 -41.46457 -5.32429  1.000 45.84942  ? 436 TRP B C   1 
ATOM   1143 O O   . TRP B 2 104 ? 30.49958 -40.40289 -4.89324  1.000 47.12947  ? 436 TRP B O   1 
ATOM   1144 C CB  . TRP B 2 104 ? 30.70347 -42.35517 -7.57937  1.000 48.34274  ? 436 TRP B CB  1 
ATOM   1145 C CG  . TRP B 2 104 ? 32.06816 -41.73863 -7.50005  1.000 49.63607  ? 436 TRP B CG  1 
ATOM   1146 C CD1 . TRP B 2 104 ? 33.08638 -42.10843 -6.67034  1.000 42.84839  ? 436 TRP B CD1 1 
ATOM   1147 C CD2 . TRP B 2 104 ? 32.56814 -40.64971 -8.28814  1.000 45.54290  ? 436 TRP B CD2 1 
ATOM   1148 N NE1 . TRP B 2 104 ? 34.18737 -41.31570 -6.88939  1.000 43.81814  ? 436 TRP B NE1 1 
ATOM   1149 C CE2 . TRP B 2 104 ? 33.89497 -40.41220 -7.87743  1.000 43.01433  ? 436 TRP B CE2 1 
ATOM   1150 C CE3 . TRP B 2 104 ? 32.02159 -39.85158 -9.29764  1.000 45.73853  ? 436 TRP B CE3 1 
ATOM   1151 C CZ2 . TRP B 2 104 ? 34.68313 -39.41018 -8.44090  1.000 43.25029  ? 436 TRP B CZ2 1 
ATOM   1152 C CZ3 . TRP B 2 104 ? 32.80568 -38.85769 -9.85571  1.000 46.88336  ? 436 TRP B CZ3 1 
ATOM   1153 C CH2 . TRP B 2 104 ? 34.12150 -38.64557 -9.42575  1.000 46.63111  ? 436 TRP B CH2 1 
ATOM   1154 N N   . ASN B 2 105 ? 29.87330 -42.55129 -4.57470  1.000 45.48557  ? 437 ASN B N   1 
ATOM   1155 C CA  . ASN B 2 105 ? 30.20670 -42.55400 -3.15743  1.000 44.90715  ? 437 ASN B CA  1 
ATOM   1156 C C   . ASN B 2 105 ? 31.71791 -42.53800 -2.96544  1.000 45.86249  ? 437 ASN B C   1 
ATOM   1157 O O   . ASN B 2 105 ? 32.44388 -43.31150 -3.59727  1.000 49.75690  ? 437 ASN B O   1 
ATOM   1158 C CB  . ASN B 2 105 ? 29.60127 -43.78142 -2.47751  1.000 51.67443  ? 437 ASN B CB  1 
ATOM   1159 C CG  . ASN B 2 105 ? 29.84947 -43.80239 -0.97954  1.000 50.41730  ? 437 ASN B CG  1 
ATOM   1160 O OD1 . ASN B 2 105 ? 30.92867 -44.17762 -0.52172  1.000 54.04929  ? 437 ASN B OD1 1 
ATOM   1161 N ND2 . ASN B 2 105 ? 28.84499 -43.40494 -0.20891  1.000 45.12857  ? 437 ASN B ND2 1 
ATOM   1162 N N   . SER B 2 106 ? 32.19099 -41.65862 -2.08225  1.000 48.38608  ? 438 SER B N   1 
ATOM   1163 C CA  . SER B 2 106 ? 33.60837 -41.55040 -1.75947  1.000 45.95948  ? 438 SER B CA  1 
ATOM   1164 C C   . SER B 2 106 ? 33.85577 -41.69785 -0.26075  1.000 51.04448  ? 438 SER B C   1 
ATOM   1165 O O   . SER B 2 106 ? 34.77402 -41.08207 0.28670   1.000 48.08246  ? 438 SER B O   1 
ATOM   1166 C CB  . SER B 2 106 ? 34.17693 -40.22597 -2.26372  1.000 45.35014  ? 438 SER B CB  1 
ATOM   1167 O OG  . SER B 2 106 ? 33.50555 -39.12901 -1.67286  1.000 44.13345  ? 438 SER B OG  1 
ATOM   1168 N N   . ASN B 2 107 ? 33.03919 -42.50756 0.41978   1.000 49.36759  ? 439 ASN B N   1 
ATOM   1169 C CA  . ASN B 2 107 ? 33.25270 -42.72359 1.84674   1.000 53.67902  ? 439 ASN B CA  1 
ATOM   1170 C C   . ASN B 2 107 ? 34.57347 -43.43167 2.10884   1.000 55.38457  ? 439 ASN B C   1 
ATOM   1171 O O   . ASN B 2 107 ? 35.16557 -43.26230 3.17933   1.000 54.88413  ? 439 ASN B O   1 
ATOM   1172 C CB  . ASN B 2 107 ? 32.08990 -43.51723 2.44259   1.000 51.45371  ? 439 ASN B CB  1 
ATOM   1173 C CG  . ASN B 2 107 ? 32.17826 -43.63614 3.95508   1.000 59.84726  ? 439 ASN B CG  1 
ATOM   1174 O OD1 . ASN B 2 107 ? 31.91580 -42.67448 4.67959   1.000 53.97158  ? 439 ASN B OD1 1 
ATOM   1175 N ND2 . ASN B 2 107 ? 32.54524 -44.81908 4.43909   1.000 59.65536  ? 439 ASN B ND2 1 
ATOM   1176 N N   . ASN B 2 108 ? 35.05706 -44.21556 1.14450   1.000 53.41265  ? 440 ASN B N   1 
ATOM   1177 C CA  . ASN B 2 108 ? 36.35312 -44.86284 1.28586   1.000 52.95253  ? 440 ASN B CA  1 
ATOM   1178 C C   . ASN B 2 108 ? 37.51432 -43.89344 1.10518   1.000 59.65256  ? 440 ASN B C   1 
ATOM   1179 O O   . ASN B 2 108 ? 38.64081 -44.22077 1.49338   1.000 59.92590  ? 440 ASN B O   1 
ATOM   1180 C CB  . ASN B 2 108 ? 36.47961 -46.01359 0.28391   1.000 57.81294  ? 440 ASN B CB  1 
ATOM   1181 C CG  . ASN B 2 108 ? 36.37608 -45.54757 -1.15574  1.000 64.20664  ? 440 ASN B CG  1 
ATOM   1182 O OD1 . ASN B 2 108 ? 35.57168 -44.67213 -1.48302  1.000 57.11486  ? 440 ASN B OD1 1 
ATOM   1183 N ND2 . ASN B 2 108 ? 37.19405 -46.13029 -2.02523  1.000 64.07379  ? 440 ASN B ND2 1 
ATOM   1184 N N   . LEU B 2 109 ? 37.27094 -42.71536 0.53330   1.000 57.02184  ? 441 LEU B N   1 
ATOM   1185 C CA  . LEU B 2 109 ? 38.31559 -41.72492 0.29658   1.000 55.05648  ? 441 LEU B CA  1 
ATOM   1186 C C   . LEU B 2 109 ? 38.16412 -40.46420 1.13011   1.000 50.49925  ? 441 LEU B C   1 
ATOM   1187 O O   . LEU B 2 109 ? 39.16037 -39.94850 1.64026   1.000 51.37765  ? 441 LEU B O   1 
ATOM   1188 C CB  . LEU B 2 109 ? 38.35178 -41.33512 -1.18648  1.000 49.66075  ? 441 LEU B CB  1 
ATOM   1189 C CG  . LEU B 2 109 ? 39.06877 -42.28169 -2.14889  1.000 52.69328  ? 441 LEU B CG  1 
ATOM   1190 C CD1 . LEU B 2 109 ? 39.00966 -41.74290 -3.57330  1.000 58.16182  ? 441 LEU B CD1 1 
ATOM   1191 C CD2 . LEU B 2 109 ? 40.50962 -42.49268 -1.71500  1.000 54.33193  ? 441 LEU B CD2 1 
ATOM   1192 N N   . ASP B 2 110 ? 36.94583 -39.94443 1.27813   1.000 50.75651  ? 442 ASP B N   1 
ATOM   1193 C CA  . ASP B 2 110 ? 36.72234 -38.67166 1.95056   1.000 52.76484  ? 442 ASP B CA  1 
ATOM   1194 C C   . ASP B 2 110 ? 36.17438 -38.83649 3.36824   1.000 51.27270  ? 442 ASP B C   1 
ATOM   1195 O O   . ASP B 2 110 ? 35.55889 -37.90608 3.89878   1.000 53.86271  ? 442 ASP B O   1 
ATOM   1196 C CB  . ASP B 2 110 ? 35.78662 -37.79519 1.11492   1.000 45.39774  ? 442 ASP B CB  1 
ATOM   1197 C CG  . ASP B 2 110 ? 36.37967 -37.42475 -0.23656  1.000 46.05300  ? 442 ASP B CG  1 
ATOM   1198 O OD1 . ASP B 2 110 ? 37.55926 -37.01862 -0.28138  1.000 41.36755  ? 442 ASP B OD1 1 
ATOM   1199 O OD2 . ASP B 2 110 ? 35.66513 -37.54109 -1.25500  1.000 40.07227  ? 442 ASP B OD2 1 
ATOM   1200 N N   . SER B 2 111 ? 36.38845 -39.99264 3.99394   1.000 58.89628  ? 443 SER B N   1 
ATOM   1201 C CA  . SER B 2 111 ? 36.01147 -40.21931 5.38570   1.000 58.09335  ? 443 SER B CA  1 
ATOM   1202 C C   . SER B 2 111 ? 37.23471 -40.68222 6.16070   1.000 57.10132  ? 443 SER B C   1 
ATOM   1203 O O   . SER B 2 111 ? 37.78826 -41.74979 5.87659   1.000 60.33447  ? 443 SER B O   1 
ATOM   1204 C CB  . SER B 2 111 ? 34.88662 -41.25016 5.50945   1.000 53.68801  ? 443 SER B CB  1 
ATOM   1205 O OG  . SER B 2 111 ? 33.63053 -40.68558 5.18220   1.000 63.50432  ? 443 SER B OG  1 
ATOM   1206 N N   . LYS B 2 112 ? 37.64951 -39.88110 7.13319   1.000 59.75660  ? 444 LYS B N   1 
ATOM   1207 C CA  . LYS B 2 112 ? 38.72384 -40.23743 8.04566   1.000 68.12166  ? 444 LYS B CA  1 
ATOM   1208 C C   . LYS B 2 112 ? 38.12519 -40.68210 9.37361   1.000 64.80738  ? 444 LYS B C   1 
ATOM   1209 O O   . LYS B 2 112 ? 37.11833 -40.12828 9.82613   1.000 63.53503  ? 444 LYS B O   1 
ATOM   1210 C CB  . LYS B 2 112 ? 39.67168 -39.05214 8.25435   1.000 67.00228  ? 444 LYS B CB  1 
ATOM   1211 C CG  . LYS B 2 112 ? 40.74354 -39.26557 9.31264   1.000 76.08953  ? 444 LYS B CG  1 
ATOM   1212 C CD  . LYS B 2 112 ? 41.66196 -40.42465 8.95718   1.000 78.38567  ? 444 LYS B CD  1 
ATOM   1213 C CE  . LYS B 2 112 ? 42.72064 -40.63286 10.02819  1.000 76.43993  ? 444 LYS B CE  1 
ATOM   1214 N NZ  . LYS B 2 112 ? 42.11428 -40.85050 11.37310  1.000 76.22962  ? 444 LYS B NZ  1 
ATOM   1215 N N   . VAL B 2 113 ? 38.73519 -41.70065 9.98250   1.000 68.80018  ? 445 VAL B N   1 
ATOM   1216 C CA  . VAL B 2 113 ? 38.28411 -42.16609 11.28994  1.000 73.83564  ? 445 VAL B CA  1 
ATOM   1217 C C   . VAL B 2 113 ? 38.36469 -41.01008 12.27547  1.000 70.10899  ? 445 VAL B C   1 
ATOM   1218 O O   . VAL B 2 113 ? 39.42341 -40.39437 12.45172  1.000 70.53973  ? 445 VAL B O   1 
ATOM   1219 C CB  . VAL B 2 113 ? 39.11394 -43.36573 11.75557  1.000 70.00188  ? 445 VAL B CB  1 
ATOM   1220 C CG1 . VAL B 2 113 ? 38.64761 -43.82935 13.12615  1.000 73.12189  ? 445 VAL B CG1 1 
ATOM   1221 C CG2 . VAL B 2 113 ? 39.01824 -44.49792 10.74495  1.000 78.68191  ? 445 VAL B CG2 1 
ATOM   1222 N N   . GLY B 2 114 ? 37.24032 -40.70284 12.91577  1.000 61.67751  ? 446 GLY B N   1 
ATOM   1223 C CA  . GLY B 2 114 ? 37.13700 -39.54142 13.77023  1.000 66.74195  ? 446 GLY B CA  1 
ATOM   1224 C C   . GLY B 2 114 ? 36.54163 -38.32150 13.10597  1.000 62.93727  ? 446 GLY B C   1 
ATOM   1225 O O   . GLY B 2 114 ? 36.40624 -37.28295 13.76397  1.000 64.10639  ? 446 GLY B O   1 
ATOM   1226 N N   . GLY B 2 115 ? 36.18750 -38.40977 11.82723  1.000 64.29648  ? 447 GLY B N   1 
ATOM   1227 C CA  . GLY B 2 115 ? 35.56037 -37.29885 11.14514  1.000 55.77006  ? 447 GLY B CA  1 
ATOM   1228 C C   . GLY B 2 115 ? 36.49161 -36.51877 10.24369  1.000 58.96375  ? 447 GLY B C   1 
ATOM   1229 O O   . GLY B 2 115 ? 37.50199 -35.97534 10.69969  1.000 57.95843  ? 447 GLY B O   1 
ATOM   1230 N N   . ASN B 2 116 ? 36.16096 -36.45961 8.95711   1.000 57.00427  ? 448 ASN B N   1 
ATOM   1231 C CA  . ASN B 2 116 ? 36.87341 -35.62633 7.99891   1.000 50.77747  ? 448 ASN B CA  1 
ATOM   1232 C C   . ASN B 2 116 ? 36.12712 -34.30491 7.86483   1.000 49.95343  ? 448 ASN B C   1 
ATOM   1233 O O   . ASN B 2 116 ? 34.95912 -34.28468 7.46079   1.000 51.48538  ? 448 ASN B O   1 
ATOM   1234 C CB  . ASN B 2 116 ? 36.99139 -36.32402 6.64451   1.000 57.14697  ? 448 ASN B CB  1 
ATOM   1235 C CG  . ASN B 2 116 ? 37.72816 -35.48501 5.61924   1.000 53.24436  ? 448 ASN B CG  1 
ATOM   1236 O OD1 . ASN B 2 116 ? 38.47690 -34.57137 5.96742   1.000 50.68280  ? 448 ASN B OD1 1 
ATOM   1237 N ND2 . ASN B 2 116 ? 37.51825 -35.79195 4.34521   1.000 57.95930  ? 448 ASN B ND2 1 
ATOM   1238 N N   . TYR B 2 117 ? 36.79733 -33.20813 8.21271   1.000 50.00924  ? 449 TYR B N   1 
ATOM   1239 C CA  . TYR B 2 117 ? 36.19726 -31.88066 8.18674   1.000 47.38246  ? 449 TYR B CA  1 
ATOM   1240 C C   . TYR B 2 117 ? 36.90738 -30.96623 7.19323   1.000 47.66167  ? 449 TYR B C   1 
ATOM   1241 O O   . TYR B 2 117 ? 36.90843 -29.74482 7.35444   1.000 52.76929  ? 449 TYR B O   1 
ATOM   1242 C CB  . TYR B 2 117 ? 36.19622 -31.26325 9.58604   1.000 54.85715  ? 449 TYR B CB  1 
ATOM   1243 C CG  . TYR B 2 117 ? 35.38209 -32.04070 10.60280  1.000 53.59381  ? 449 TYR B CG  1 
ATOM   1244 C CD1 . TYR B 2 117 ? 35.93514 -33.11251 11.29427  1.000 59.15573  ? 449 TYR B CD1 1 
ATOM   1245 C CD2 . TYR B 2 117 ? 34.06162 -31.70153 10.87177  1.000 57.06592  ? 449 TYR B CD2 1 
ATOM   1246 C CE1 . TYR B 2 117 ? 35.19524 -33.82536 12.22291  1.000 60.37180  ? 449 TYR B CE1 1 
ATOM   1247 C CE2 . TYR B 2 117 ? 33.31441 -32.40894 11.79914  1.000 60.86631  ? 449 TYR B CE2 1 
ATOM   1248 C CZ  . TYR B 2 117 ? 33.88696 -33.46866 12.47175  1.000 60.73967  ? 449 TYR B CZ  1 
ATOM   1249 O OH  . TYR B 2 117 ? 33.14953 -34.17509 13.39459  1.000 60.71833  ? 449 TYR B OH  1 
ATOM   1250 N N   . ASN B 2 118 ? 37.50930 -31.54687 6.15226   1.000 49.01913  ? 450 ASN B N   1 
ATOM   1251 C CA  . ASN B 2 118 ? 38.22563 -30.75619 5.15891   1.000 53.07879  ? 450 ASN B CA  1 
ATOM   1252 C C   . ASN B 2 118 ? 37.31658 -30.19580 4.07334   1.000 49.66392  ? 450 ASN B C   1 
ATOM   1253 O O   . ASN B 2 118 ? 37.73337 -29.28552 3.34805   1.000 50.08763  ? 450 ASN B O   1 
ATOM   1254 C CB  . ASN B 2 118 ? 39.33046 -31.59253 4.50830   1.000 52.71011  ? 450 ASN B CB  1 
ATOM   1255 C CG  . ASN B 2 118 ? 40.40704 -32.00139 5.49103   1.000 56.23032  ? 450 ASN B CG  1 
ATOM   1256 O OD1 . ASN B 2 118 ? 40.53733 -31.41703 6.56680   1.000 60.88974  ? 450 ASN B OD1 1 
ATOM   1257 N ND2 . ASN B 2 118 ? 41.19168 -33.00592 5.12260   1.000 57.38849  ? 450 ASN B ND2 1 
ATOM   1258 N N   . TYR B 2 119 ? 36.09975 -30.71382 3.93627   1.000 46.47784  ? 451 TYR B N   1 
ATOM   1259 C CA  . TYR B 2 119 ? 35.16302 -30.24377 2.92426   1.000 42.43656  ? 451 TYR B CA  1 
ATOM   1260 C C   . TYR B 2 119 ? 34.16655 -29.28330 3.55630   1.000 41.25706  ? 451 TYR B C   1 
ATOM   1261 O O   . TYR B 2 119 ? 33.60302 -29.57207 4.61763   1.000 48.46229  ? 451 TYR B O   1 
ATOM   1262 C CB  . TYR B 2 119 ? 34.43482 -31.41365 2.26227   1.000 43.29999  ? 451 TYR B CB  1 
ATOM   1263 C CG  . TYR B 2 119 ? 35.34453 -32.28861 1.43275   1.000 45.24039  ? 451 TYR B CG  1 
ATOM   1264 C CD1 . TYR B 2 119 ? 35.69897 -31.92662 0.13796   1.000 42.26482  ? 451 TYR B CD1 1 
ATOM   1265 C CD2 . TYR B 2 119 ? 35.85526 -33.47190 1.94498   1.000 46.22136  ? 451 TYR B CD2 1 
ATOM   1266 C CE1 . TYR B 2 119 ? 36.53402 -32.72229 -0.62171  1.000 41.31864  ? 451 TYR B CE1 1 
ATOM   1267 C CE2 . TYR B 2 119 ? 36.68913 -34.27394 1.19373   1.000 45.35525  ? 451 TYR B CE2 1 
ATOM   1268 C CZ  . TYR B 2 119 ? 37.02465 -33.89685 -0.08836  1.000 46.60854  ? 451 TYR B CZ  1 
ATOM   1269 O OH  . TYR B 2 119 ? 37.85848 -34.69798 -0.83241  1.000 44.09733  ? 451 TYR B OH  1 
ATOM   1270 N N   . LEU B 2 120 ? 33.95413 -28.14734 2.90013   1.000 41.59075  ? 452 LEU B N   1 
ATOM   1271 C CA  . LEU B 2 120 ? 33.13562 -27.06660 3.42152   1.000 38.58450  ? 452 LEU B CA  1 
ATOM   1272 C C   . LEU B 2 120 ? 31.97036 -26.78196 2.48373   1.000 41.24308  ? 452 LEU B C   1 
ATOM   1273 O O   . LEU B 2 120 ? 32.01638 -27.07847 1.28618   1.000 42.35854  ? 452 LEU B O   1 
ATOM   1274 C CB  . LEU B 2 120 ? 33.96483 -25.78881 3.60584   1.000 41.08824  ? 452 LEU B CB  1 
ATOM   1275 C CG  . LEU B 2 120 ? 35.26145 -25.91288 4.40645   1.000 48.86824  ? 452 LEU B CG  1 
ATOM   1276 C CD1 . LEU B 2 120 ? 36.25137 -24.84233 3.98000   1.000 50.96880  ? 452 LEU B CD1 1 
ATOM   1277 C CD2 . LEU B 2 120 ? 34.98257 -25.81582 5.89861   1.000 45.09779  ? 452 LEU B CD2 1 
ATOM   1278 N N   . TYR B 2 121 ? 30.92205 -26.19038 3.05048   1.000 39.91370  ? 453 TYR B N   1 
ATOM   1279 C CA  . TYR B 2 121 ? 29.78103 -25.70761 2.28932   1.000 36.77454  ? 453 TYR B CA  1 
ATOM   1280 C C   . TYR B 2 121 ? 29.36356 -24.35647 2.84773   1.000 36.99240  ? 453 TYR B C   1 
ATOM   1281 O O   . TYR B 2 121 ? 29.62026 -24.04385 4.01353   1.000 40.48607  ? 453 TYR B O   1 
ATOM   1282 C CB  . TYR B 2 121 ? 28.59705 -26.68966 2.33608   1.000 40.35026  ? 453 TYR B CB  1 
ATOM   1283 C CG  . TYR B 2 121 ? 28.09101 -26.98281 3.73213   1.000 36.91434  ? 453 TYR B CG  1 
ATOM   1284 C CD1 . TYR B 2 121 ? 27.07992 -26.21989 4.30273   1.000 41.14500  ? 453 TYR B CD1 1 
ATOM   1285 C CD2 . TYR B 2 121 ? 28.62561 -28.02304 4.47943   1.000 41.94833  ? 453 TYR B CD2 1 
ATOM   1286 C CE1 . TYR B 2 121 ? 26.61921 -26.48268 5.58286   1.000 43.93046  ? 453 TYR B CE1 1 
ATOM   1287 C CE2 . TYR B 2 121 ? 28.17233 -28.29317 5.76047   1.000 41.75754  ? 453 TYR B CE2 1 
ATOM   1288 C CZ  . TYR B 2 121 ? 27.16801 -27.52185 6.30597   1.000 39.65883  ? 453 TYR B CZ  1 
ATOM   1289 O OH  . TYR B 2 121 ? 26.71170 -27.79091 7.57738   1.000 42.49288  ? 453 TYR B OH  1 
ATOM   1290 N N   . ARG B 2 122 ? 28.72105 -23.55518 2.00662   1.000 35.59000  ? 454 ARG B N   1 
ATOM   1291 C CA  . ARG B 2 122 ? 28.21472 -22.25523 2.42191   1.000 36.33397  ? 454 ARG B CA  1 
ATOM   1292 C C   . ARG B 2 122 ? 26.83022 -22.44178 3.02755   1.000 38.93244  ? 454 ARG B C   1 
ATOM   1293 O O   . ARG B 2 122 ? 25.92195 -22.96164 2.36988   1.000 37.52080  ? 454 ARG B O   1 
ATOM   1294 C CB  . ARG B 2 122 ? 28.16701 -21.28056 1.24706   1.000 36.71995  ? 454 ARG B CB  1 
ATOM   1295 C CG  . ARG B 2 122 ? 27.73093 -19.87535 1.63472   1.000 38.47399  ? 454 ARG B CG  1 
ATOM   1296 C CD  . ARG B 2 122 ? 27.84502 -18.91068 0.46294   1.000 40.83990  ? 454 ARG B CD  1 
ATOM   1297 N NE  . ARG B 2 122 ? 29.21576 -18.79810 -0.02167  1.000 37.75142  ? 454 ARG B NE  1 
ATOM   1298 C CZ  . ARG B 2 122 ? 30.12136 -17.96855 0.47766   1.000 41.65742  ? 454 ARG B CZ  1 
ATOM   1299 N NH1 . ARG B 2 122 ? 29.83691 -17.15851 1.48518   1.000 45.75665  ? 454 ARG B NH1 1 
ATOM   1300 N NH2 . ARG B 2 122 ? 31.34437 -17.95476 -0.04283  1.000 42.66236  ? 454 ARG B NH2 1 
ATOM   1301 N N   . LEU B 2 123 ? 26.67767 -22.03497 4.28525   1.000 38.76225  ? 455 LEU B N   1 
ATOM   1302 C CA  . LEU B 2 123 ? 25.40245 -22.16223 4.97537   1.000 37.13957  ? 455 LEU B CA  1 
ATOM   1303 C C   . LEU B 2 123 ? 24.58281 -20.88293 4.92053   1.000 35.22089  ? 455 LEU B C   1 
ATOM   1304 O O   . LEU B 2 123 ? 23.34842 -20.94445 4.88622   1.000 37.32226  ? 455 LEU B O   1 
ATOM   1305 C CB  . LEU B 2 123 ? 25.63980 -22.56752 6.43403   1.000 39.72517  ? 455 LEU B CB  1 
ATOM   1306 C CG  . LEU B 2 123 ? 24.43969 -22.71984 7.36990   1.000 39.15027  ? 455 LEU B CG  1 
ATOM   1307 C CD1 . LEU B 2 123 ? 23.43182 -23.71208 6.80463   1.000 36.59197  ? 455 LEU B CD1 1 
ATOM   1308 C CD2 . LEU B 2 123 ? 24.90732 -23.15839 8.75012   1.000 37.88771  ? 455 LEU B CD2 1 
ATOM   1309 N N   . PHE B 2 124 ? 25.24136 -19.72915 4.88555   1.000 37.94068  ? 456 PHE B N   1 
ATOM   1310 C CA  . PHE B 2 124 ? 24.57755 -18.43585 4.94643   1.000 40.12413  ? 456 PHE B CA  1 
ATOM   1311 C C   . PHE B 2 124 ? 24.89036 -17.64045 3.68860   1.000 44.50435  ? 456 PHE B C   1 
ATOM   1312 O O   . PHE B 2 124 ? 26.04670 -17.57853 3.25945   1.000 44.83296  ? 456 PHE B O   1 
ATOM   1313 C CB  . PHE B 2 124 ? 25.02068 -17.64696 6.18363   1.000 41.15835  ? 456 PHE B CB  1 
ATOM   1314 C CG  . PHE B 2 124 ? 24.91015 -18.41406 7.47384   1.000 38.11819  ? 456 PHE B CG  1 
ATOM   1315 C CD1 . PHE B 2 124 ? 23.72316 -18.42978 8.18652   1.000 40.26555  ? 456 PHE B CD1 1 
ATOM   1316 C CD2 . PHE B 2 124 ? 26.00067 -19.09945 7.98614   1.000 41.65691  ? 456 PHE B CD2 1 
ATOM   1317 C CE1 . PHE B 2 124 ? 23.62176 -19.12482 9.38099   1.000 38.37404  ? 456 PHE B CE1 1 
ATOM   1318 C CE2 . PHE B 2 124 ? 25.90462 -19.79603 9.17967   1.000 41.82928  ? 456 PHE B CE2 1 
ATOM   1319 C CZ  . PHE B 2 124 ? 24.71386 -19.80731 9.87673   1.000 35.60963  ? 456 PHE B CZ  1 
ATOM   1320 N N   . ARG B 2 125 ? 23.86374 -17.02718 3.10791   1.000 42.77399  ? 457 ARG B N   1 
ATOM   1321 C CA  . ARG B 2 125 ? 24.05994 -16.12877 1.98272   1.000 41.10473  ? 457 ARG B CA  1 
ATOM   1322 C C   . ARG B 2 125 ? 22.85127 -15.21257 1.89560   1.000 46.12269  ? 457 ARG B C   1 
ATOM   1323 O O   . ARG B 2 125 ? 21.72427 -15.64051 2.15565   1.000 49.00267  ? 457 ARG B O   1 
ATOM   1324 C CB  . ARG B 2 125 ? 24.25649 -16.89820 0.67098   1.000 44.40758  ? 457 ARG B CB  1 
ATOM   1325 C CG  . ARG B 2 125 ? 25.02669 -16.12293 -0.38556  1.000 41.29599  ? 457 ARG B CG  1 
ATOM   1326 C CD  . ARG B 2 125 ? 25.27795 -16.96491 -1.62422  1.000 43.51518  ? 457 ARG B CD  1 
ATOM   1327 N NE  . ARG B 2 125 ? 26.19282 -16.30024 -2.54385  1.000 40.98969  ? 457 ARG B NE  1 
ATOM   1328 C CZ  . ARG B 2 125 ? 25.82159 -15.42052 -3.46336  1.000 43.92632  ? 457 ARG B CZ  1 
ATOM   1329 N NH1 . ARG B 2 125 ? 24.55053 -15.09400 -3.63567  1.000 47.36530  ? 457 ARG B NH1 1 
ATOM   1330 N NH2 . ARG B 2 125 ? 26.74856 -14.85304 -4.22777  1.000 41.87340  ? 457 ARG B NH2 1 
ATOM   1331 N N   . LYS B 2 126 ? 23.09633 -13.95062 1.54030   1.000 44.12880  ? 458 LYS B N   1 
ATOM   1332 C CA  . LYS B 2 126 ? 22.01561 -12.97450 1.48528   1.000 51.41966  ? 458 LYS B CA  1 
ATOM   1333 C C   . LYS B 2 126 ? 21.11589 -13.16350 0.27021   1.000 53.28016  ? 458 LYS B C   1 
ATOM   1334 O O   . LYS B 2 126 ? 19.97132 -12.69731 0.28670   1.000 59.38689  ? 458 LYS B O   1 
ATOM   1335 C CB  . LYS B 2 126 ? 22.59073 -11.55707 1.50207   1.000 48.44194  ? 458 LYS B CB  1 
ATOM   1336 C CG  . LYS B 2 126 ? 23.38201 -11.24383 2.76303   1.000 56.93514  ? 458 LYS B CG  1 
ATOM   1337 C CD  . LYS B 2 126 ? 23.85476 -9.80074  2.80445   1.000 63.93839  ? 458 LYS B CD  1 
ATOM   1338 C CE  . LYS B 2 126 ? 24.63978 -9.52268  4.08046   1.000 66.66661  ? 458 LYS B CE  1 
ATOM   1339 N NZ  . LYS B 2 126 ? 23.83707 -9.79803  5.30896   1.000 51.85515  ? 458 LYS B NZ  1 
ATOM   1340 N N   . SER B 2 127 ? 21.59570 -13.83667 -0.77405  1.000 47.44149  ? 459 SER B N   1 
ATOM   1341 C CA  . SER B 2 127 ? 20.78926 -14.06615 -1.96332  1.000 46.54064  ? 459 SER B CA  1 
ATOM   1342 C C   . SER B 2 127 ? 21.20023 -15.38300 -2.60476  1.000 47.73459  ? 459 SER B C   1 
ATOM   1343 O O   . SER B 2 127 ? 22.30255 -15.88989 -2.38051  1.000 47.57588  ? 459 SER B O   1 
ATOM   1344 C CB  . SER B 2 127 ? 20.92957 -12.91686 -2.96722  1.000 49.79490  ? 459 SER B CB  1 
ATOM   1345 O OG  . SER B 2 127 ? 22.27490 -12.77763 -3.38830  1.000 55.72681  ? 459 SER B OG  1 
ATOM   1346 N N   . ASN B 2 128 ? 20.29453 -15.93102 -3.41114  1.000 48.03856  ? 460 ASN B N   1 
ATOM   1347 C CA  . ASN B 2 128 ? 20.56961 -17.17061 -4.11992  1.000 49.83982  ? 460 ASN B CA  1 
ATOM   1348 C C   . ASN B 2 128 ? 21.61710 -16.95016 -5.20846  1.000 50.92602  ? 460 ASN B C   1 
ATOM   1349 O O   . ASN B 2 128 ? 21.82395 -15.83748 -5.70077  1.000 47.87237  ? 460 ASN B O   1 
ATOM   1350 C CB  . ASN B 2 128 ? 19.29058 -17.73711 -4.73893  1.000 44.06772  ? 460 ASN B CB  1 
ATOM   1351 C CG  . ASN B 2 128 ? 18.30568 -18.22681 -3.69602  1.000 49.27503  ? 460 ASN B CG  1 
ATOM   1352 O OD1 . ASN B 2 128 ? 18.68714 -18.56209 -2.57397  1.000 47.49124  ? 460 ASN B OD1 1 
ATOM   1353 N ND2 . ASN B 2 128 ? 17.03040 -18.27595 -4.06326  1.000 47.08943  ? 460 ASN B ND2 1 
ATOM   1354 N N   . LEU B 2 129 ? 22.27822 -18.03855 -5.58595  1.000 45.86708  ? 461 LEU B N   1 
ATOM   1355 C CA  . LEU B 2 129 ? 23.30639 -17.98058 -6.61034  1.000 47.34824  ? 461 LEU B CA  1 
ATOM   1356 C C   . LEU B 2 129 ? 22.69408 -17.88849 -8.00288  1.000 44.92576  ? 461 LEU B C   1 
ATOM   1357 O O   . LEU B 2 129 ? 21.62677 -18.44360 -8.27975  1.000 41.72840  ? 461 LEU B O   1 
ATOM   1358 C CB  . LEU B 2 129 ? 24.20941 -19.21217 -6.53864  1.000 43.41586  ? 461 LEU B CB  1 
ATOM   1359 C CG  . LEU B 2 129 ? 25.29915 -19.26380 -5.47045  1.000 42.26266  ? 461 LEU B CG  1 
ATOM   1360 C CD1 . LEU B 2 129 ? 26.08988 -20.54577 -5.62016  1.000 34.93312  ? 461 LEU B CD1 1 
ATOM   1361 C CD2 . LEU B 2 129 ? 26.21625 -18.05993 -5.58085  1.000 41.44379  ? 461 LEU B CD2 1 
ATOM   1362 N N   . LYS B 2 130 ? 23.38482 -17.17050 -8.88111  1.000 43.66176  ? 462 LYS B N   1 
ATOM   1363 C CA  . LYS B 2 130 ? 23.10393 -17.26619 -10.29764 1.000 46.02722  ? 462 LYS B CA  1 
ATOM   1364 C C   . LYS B 2 130 ? 23.63911 -18.59699 -10.81932 1.000 45.12647  ? 462 LYS B C   1 
ATOM   1365 O O   . LYS B 2 130 ? 24.51811 -19.20292 -10.20215 1.000 44.74826  ? 462 LYS B O   1 
ATOM   1366 C CB  . LYS B 2 130 ? 23.74642 -16.10246 -11.04694 1.000 47.23783  ? 462 LYS B CB  1 
ATOM   1367 C CG  . LYS B 2 130 ? 23.34306 -14.73034 -10.54058 1.000 49.04689  ? 462 LYS B CG  1 
ATOM   1368 C CD  . LYS B 2 130 ? 24.16596 -13.64345 -11.21183 1.000 57.24926  ? 462 LYS B CD  1 
ATOM   1369 C CE  . LYS B 2 130 ? 23.82118 -12.26728 -10.66794 1.000 69.55384  ? 462 LYS B CE  1 
ATOM   1370 N NZ  . LYS B 2 130 ? 24.63907 -11.20093 -11.31395 1.000 72.04220  ? 462 LYS B NZ  1 
ATOM   1371 N N   . PRO B 2 131 ? 23.11054 -19.08749 -11.93933 1.000 47.86753  ? 463 PRO B N   1 
ATOM   1372 C CA  . PRO B 2 131 ? 23.63390 -20.33943 -12.50309 1.000 46.79647  ? 463 PRO B CA  1 
ATOM   1373 C C   . PRO B 2 131 ? 25.12382 -20.23061 -12.79786 1.000 43.96557  ? 463 PRO B C   1 
ATOM   1374 O O   . PRO B 2 131 ? 25.58877 -19.24980 -13.38236 1.000 44.50920  ? 463 PRO B O   1 
ATOM   1375 C CB  . PRO B 2 131 ? 22.80905 -20.52282 -13.78092 1.000 44.22158  ? 463 PRO B CB  1 
ATOM   1376 C CG  . PRO B 2 131 ? 21.52767 -19.80661 -13.49519 1.000 41.76198  ? 463 PRO B CG  1 
ATOM   1377 C CD  . PRO B 2 131 ? 21.91333 -18.61667 -12.65922 1.000 47.65917  ? 463 PRO B CD  1 
ATOM   1378 N N   . PHE B 2 132 ? 25.87356 -21.24340 -12.35685 1.000 42.25771  ? 464 PHE B N   1 
ATOM   1379 C CA  . PHE B 2 132 ? 27.32314 -21.33906 -12.52288 1.000 43.89347  ? 464 PHE B CA  1 
ATOM   1380 C C   . PHE B 2 132 ? 28.08580 -20.23357 -11.80049 1.000 44.47008  ? 464 PHE B C   1 
ATOM   1381 O O   . PHE B 2 132 ? 29.26167 -19.99884 -12.09790 1.000 45.98444  ? 464 PHE B O   1 
ATOM   1382 C CB  . PHE B 2 132 ? 27.71690 -21.35846 -14.00397 1.000 44.22177  ? 464 PHE B CB  1 
ATOM   1383 C CG  . PHE B 2 132 ? 27.28449 -22.59679 -14.72373 1.000 42.58142  ? 464 PHE B CG  1 
ATOM   1384 C CD1 . PHE B 2 132 ? 27.54688 -23.84775 -14.19308 1.000 43.41607  ? 464 PHE B CD1 1 
ATOM   1385 C CD2 . PHE B 2 132 ? 26.60226 -22.51210 -15.92403 1.000 45.45827  ? 464 PHE B CD2 1 
ATOM   1386 C CE1 . PHE B 2 132 ? 27.14666 -24.99251 -14.85312 1.000 41.69915  ? 464 PHE B CE1 1 
ATOM   1387 C CE2 . PHE B 2 132 ? 26.19853 -23.65320 -16.58796 1.000 42.28222  ? 464 PHE B CE2 1 
ATOM   1388 C CZ  . PHE B 2 132 ? 26.47059 -24.89435 -16.05044 1.000 43.67544  ? 464 PHE B CZ  1 
ATOM   1389 N N   . GLU B 2 133 ? 27.45290 -19.54895 -10.85118 1.000 44.89543  ? 465 GLU B N   1 
ATOM   1390 C CA  . GLU B 2 133 ? 28.15165 -18.55777 -10.04629 1.000 46.36668  ? 465 GLU B CA  1 
ATOM   1391 C C   . GLU B 2 133 ? 28.91894 -19.24666 -8.92574  1.000 41.05528  ? 465 GLU B C   1 
ATOM   1392 O O   . GLU B 2 133 ? 28.43835 -20.21364 -8.32888  1.000 40.26810  ? 465 GLU B O   1 
ATOM   1393 C CB  . GLU B 2 133 ? 27.16694 -17.54236 -9.46445  1.000 43.48639  ? 465 GLU B CB  1 
ATOM   1394 C CG  . GLU B 2 133 ? 27.82457 -16.43782 -8.65144  1.000 46.21298  ? 465 GLU B CG  1 
ATOM   1395 C CD  . GLU B 2 133 ? 26.82689 -15.43846 -8.09459  1.000 49.57980  ? 465 GLU B CD  1 
ATOM   1396 O OE1 . GLU B 2 133 ? 25.61090 -15.62540 -8.30758  1.000 51.10317  ? 465 GLU B OE1 1 
ATOM   1397 O OE2 . GLU B 2 133 ? 27.26098 -14.46455 -7.44330  1.000 50.58662  ? 465 GLU B OE2 1 
ATOM   1398 N N   . ARG B 2 134 ? 30.12306 -18.75302 -8.64927  1.000 38.45692  ? 466 ARG B N   1 
ATOM   1399 C CA  . ARG B 2 134 ? 30.96200 -19.29494 -7.58805  1.000 44.56022  ? 466 ARG B CA  1 
ATOM   1400 C C   . ARG B 2 134 ? 31.25513 -18.19693 -6.57617  1.000 45.60050  ? 466 ARG B C   1 
ATOM   1401 O O   . ARG B 2 134 ? 31.85499 -17.17293 -6.92172  1.000 49.74043  ? 466 ARG B O   1 
ATOM   1402 C CB  . ARG B 2 134 ? 32.26309 -19.87555 -8.14611  1.000 41.18360  ? 466 ARG B CB  1 
ATOM   1403 C CG  . ARG B 2 134 ? 32.93090 -20.84630 -7.19024  1.000 39.81139  ? 466 ARG B CG  1 
ATOM   1404 C CD  . ARG B 2 134 ? 34.14458 -21.52469 -7.79652  1.000 40.47917  ? 466 ARG B CD  1 
ATOM   1405 N NE  . ARG B 2 134 ? 35.37640 -20.79834 -7.51691  1.000 45.79580  ? 466 ARG B NE  1 
ATOM   1406 C CZ  . ARG B 2 134 ? 36.56161 -21.37176 -7.35920  1.000 43.27486  ? 466 ARG B CZ  1 
ATOM   1407 N NH1 . ARG B 2 134 ? 36.70892 -22.68463 -7.43279  1.000 46.03648  ? 466 ARG B NH1 1 
ATOM   1408 N NH2 . ARG B 2 134 ? 37.62371 -20.60988 -7.11226  1.000 39.49350  ? 466 ARG B NH2 1 
ATOM   1409 N N   . ASP B 2 135 ? 30.83326 -18.41279 -5.33332  1.000 42.81473  ? 467 ASP B N   1 
ATOM   1410 C CA  . ASP B 2 135 ? 31.08020 -17.48822 -4.23366  1.000 41.10896  ? 467 ASP B CA  1 
ATOM   1411 C C   . ASP B 2 135 ? 32.10845 -18.11156 -3.30118  1.000 40.84098  ? 467 ASP B C   1 
ATOM   1412 O O   . ASP B 2 135 ? 31.84902 -19.15894 -2.69960  1.000 43.27975  ? 467 ASP B O   1 
ATOM   1413 C CB  . ASP B 2 135 ? 29.78740 -17.17738 -3.47814  1.000 46.37089  ? 467 ASP B CB  1 
ATOM   1414 C CG  . ASP B 2 135 ? 29.92304 -15.98842 -2.54224  1.000 44.41426  ? 467 ASP B CG  1 
ATOM   1415 O OD1 . ASP B 2 135 ? 31.03702 -15.73680 -2.03537  1.000 44.98703  ? 467 ASP B OD1 1 
ATOM   1416 O OD2 . ASP B 2 135 ? 28.90700 -15.30027 -2.31531  1.000 46.26602  ? 467 ASP B OD2 1 
ATOM   1417 N N   . ILE B 2 136 ? 33.26741 -17.46826 -3.18247  1.000 44.66014  ? 468 ILE B N   1 
ATOM   1418 C CA  . ILE B 2 136 ? 34.32696 -17.92304 -2.29389  1.000 45.98693  ? 468 ILE B CA  1 
ATOM   1419 C C   . ILE B 2 136 ? 34.61457 -16.89991 -1.19774  1.000 45.54927  ? 468 ILE B C   1 
ATOM   1420 O O   . ILE B 2 136 ? 35.64241 -16.97880 -0.53214  1.000 44.50415  ? 468 ILE B O   1 
ATOM   1421 C CB  . ILE B 2 136 ? 35.60763 -18.26324 -3.07890  1.000 44.78322  ? 468 ILE B CB  1 
ATOM   1422 C CG1 . ILE B 2 136 ? 36.12846 -17.02370 -3.81023  1.000 51.30591  ? 468 ILE B CG1 1 
ATOM   1423 C CG2 . ILE B 2 136 ? 35.34943 -19.40518 -4.04763  1.000 47.84529  ? 468 ILE B CG2 1 
ATOM   1424 C CD1 . ILE B 2 136 ? 37.45182 -17.23894 -4.51622  1.000 58.68778  ? 468 ILE B CD1 1 
ATOM   1425 N N   . SER B 2 137 ? 33.71630 -15.93630 -1.00742  1.000 44.49343  ? 469 SER B N   1 
ATOM   1426 C CA  . SER B 2 137 ? 33.89795 -14.93880 0.03882   1.000 44.01496  ? 469 SER B CA  1 
ATOM   1427 C C   . SER B 2 137 ? 33.71839 -15.56714 1.41691   1.000 48.00557  ? 469 SER B C   1 
ATOM   1428 O O   . SER B 2 137 ? 32.84562 -16.41520 1.62177   1.000 48.46699  ? 469 SER B O   1 
ATOM   1429 C CB  . SER B 2 137 ? 32.90632 -13.79061 -0.14495  1.000 43.72357  ? 469 SER B CB  1 
ATOM   1430 O OG  . SER B 2 137 ? 31.57236 -14.23405 0.04495   1.000 44.96449  ? 469 SER B OG  1 
ATOM   1431 N N   . THR B 2 138 ? 34.55255 -15.14316 2.36928   1.000 49.51440  ? 470 THR B N   1 
ATOM   1432 C CA  . THR B 2 138 ? 34.49710 -15.64188 3.73975   1.000 52.13775  ? 470 THR B CA  1 
ATOM   1433 C C   . THR B 2 138 ? 34.18680 -14.52483 4.73137   1.000 50.01283  ? 470 THR B C   1 
ATOM   1434 O O   . THR B 2 138 ? 34.61690 -14.57293 5.88561   1.000 55.34512  ? 470 THR B O   1 
ATOM   1435 C CB  . THR B 2 138 ? 35.80133 -16.34103 4.12598   1.000 48.76165  ? 470 THR B CB  1 
ATOM   1436 O OG1 . THR B 2 138 ? 36.84158 -15.36851 4.28364   1.000 54.63451  ? 470 THR B OG1 1 
ATOM   1437 C CG2 . THR B 2 138 ? 36.21014 -17.34558 3.05622   1.000 55.32904  ? 470 THR B CG2 1 
ATOM   1438 N N   . GLU B 2 139 ? 33.44421 -13.51214 4.29575   1.000 51.41629  ? 471 GLU B N   1 
ATOM   1439 C CA  . GLU B 2 139 ? 33.05710 -12.43820 5.19675   1.000 49.45517  ? 471 GLU B CA  1 
ATOM   1440 C C   . GLU B 2 139 ? 31.98613 -12.91544 6.16966   1.000 52.99538  ? 471 GLU B C   1 
ATOM   1441 O O   . GLU B 2 139 ? 31.12530 -13.73239 5.83099   1.000 49.90225  ? 471 GLU B O   1 
ATOM   1442 C CB  . GLU B 2 139 ? 32.54644 -11.22978 4.41200   1.000 55.60475  ? 471 GLU B CB  1 
ATOM   1443 C CG  . GLU B 2 139 ? 33.63885 -10.42618 3.72734   1.000 69.40880  ? 471 GLU B CG  1 
ATOM   1444 C CD  . GLU B 2 139 ? 33.14234 -9.08705  3.21633   1.000 79.49693  ? 471 GLU B CD  1 
ATOM   1445 O OE1 . GLU B 2 139 ? 31.97062 -8.74413  3.48525   1.000 73.04859  ? 471 GLU B OE1 1 
ATOM   1446 O OE2 . GLU B 2 139 ? 33.92440 -8.37696  2.54829   1.000 84.85530  ? 471 GLU B OE2 1 
ATOM   1447 N N   . ILE B 2 140 ? 32.04686 -12.38808 7.39496   1.000 44.57018  ? 472 ILE B N   1 
ATOM   1448 C CA  . ILE B 2 140 ? 31.09002 -12.77726 8.42245   1.000 44.53261  ? 472 ILE B CA  1 
ATOM   1449 C C   . ILE B 2 140 ? 29.68826 -12.38070 7.98592   1.000 47.53084  ? 472 ILE B C   1 
ATOM   1450 O O   . ILE B 2 140 ? 29.45450 -11.25491 7.52756   1.000 46.43234  ? 472 ILE B O   1 
ATOM   1451 C CB  . ILE B 2 140 ? 31.46553 -12.14039 9.76888   1.000 46.27470  ? 472 ILE B CB  1 
ATOM   1452 C CG1 . ILE B 2 140 ? 32.93045 -12.42848 10.10347  1.000 44.65366  ? 472 ILE B CG1 1 
ATOM   1453 C CG2 . ILE B 2 140 ? 30.55800 -12.65324 10.87330  1.000 48.00545  ? 472 ILE B CG2 1 
ATOM   1454 C CD1 . ILE B 2 140 ? 33.26930 -13.90591 10.15875  1.000 47.80435  ? 472 ILE B CD1 1 
ATOM   1455 N N   . TYR B 2 141 ? 28.74722 -13.31111 8.11959   1.000 49.47978  ? 473 TYR B N   1 
ATOM   1456 C CA  . TYR B 2 141 ? 27.37519 -13.09622 7.68408   1.000 45.87626  ? 473 TYR B CA  1 
ATOM   1457 C C   . TYR B 2 141 ? 26.57773 -12.41426 8.78781   1.000 46.26117  ? 473 TYR B C   1 
ATOM   1458 O O   . TYR B 2 141 ? 26.53278 -12.90072 9.92183   1.000 47.22222  ? 473 TYR B O   1 
ATOM   1459 C CB  . TYR B 2 141 ? 26.72277 -14.42440 7.30456   1.000 43.13671  ? 473 TYR B CB  1 
ATOM   1460 C CG  . TYR B 2 141 ? 25.32025 -14.28576 6.76388   1.000 47.77297  ? 473 TYR B CG  1 
ATOM   1461 C CD1 . TYR B 2 141 ? 25.09785 -14.03341 5.41770   1.000 46.19889  ? 473 TYR B CD1 1 
ATOM   1462 C CD2 . TYR B 2 141 ? 24.21764 -14.41619 7.59662   1.000 47.09555  ? 473 TYR B CD2 1 
ATOM   1463 C CE1 . TYR B 2 141 ? 23.81668 -13.90940 4.91745   1.000 50.44380  ? 473 TYR B CE1 1 
ATOM   1464 C CE2 . TYR B 2 141 ? 22.93424 -14.29336 7.10585   1.000 47.38916  ? 473 TYR B CE2 1 
ATOM   1465 C CZ  . TYR B 2 141 ? 22.73762 -14.03899 5.76575   1.000 50.16856  ? 473 TYR B CZ  1 
ATOM   1466 O OH  . TYR B 2 141 ? 21.45791 -13.91427 5.27217   1.000 51.88732  ? 473 TYR B OH  1 
ATOM   1467 N N   . GLN B 2 142 ? 25.94602 -11.29319 8.45034   1.000 50.28286  ? 474 GLN B N   1 
ATOM   1468 C CA  . GLN B 2 142 ? 25.10493 -10.55503 9.39022   1.000 53.23779  ? 474 GLN B CA  1 
ATOM   1469 C C   . GLN B 2 142 ? 23.67224 -11.05272 9.23852   1.000 54.41128  ? 474 GLN B C   1 
ATOM   1470 O O   . GLN B 2 142 ? 22.92682 -10.58718 8.37258   1.000 49.48546  ? 474 GLN B O   1 
ATOM   1471 C CB  . GLN B 2 142 ? 25.21104 -9.05475  9.14214   1.000 55.03691  ? 474 GLN B CB  1 
ATOM   1472 C CG  . GLN B 2 142 ? 24.35192 -8.21149  10.06722  1.000 59.50046  ? 474 GLN B CG  1 
ATOM   1473 C CD  . GLN B 2 142 ? 24.58408 -6.72600  9.88212   1.000 59.12458  ? 474 GLN B CD  1 
ATOM   1474 O OE1 . GLN B 2 142 ? 25.66656 -6.30070  9.47771   1.000 53.59938  ? 474 GLN B OE1 1 
ATOM   1475 N NE2 . GLN B 2 142 ? 23.56496 -5.92685  10.17666  1.000 58.49714  ? 474 GLN B NE2 1 
ATOM   1476 N N   . ALA B 2 143 ? 23.28239 -12.00421 10.09038  1.000 56.10688  ? 475 ALA B N   1 
ATOM   1477 C CA  . ALA B 2 143 ? 21.95272 -12.59516 10.00283  1.000 55.17636  ? 475 ALA B CA  1 
ATOM   1478 C C   . ALA B 2 143 ? 20.88143 -11.75779 10.68803  1.000 56.11880  ? 475 ALA B C   1 
ATOM   1479 O O   . ALA B 2 143 ? 19.69228 -11.96297 10.42158  1.000 53.40670  ? 475 ALA B O   1 
ATOM   1480 C CB  . ALA B 2 143 ? 21.96313 -14.00312 10.60015  1.000 51.07131  ? 475 ALA B CB  1 
ATOM   1481 N N   . GLY B 2 144 ? 21.26797 -10.82892 11.55902  1.000 57.40919  ? 476 GLY B N   1 
ATOM   1482 C CA  . GLY B 2 144 ? 20.30327 -9.99535  12.24817  1.000 57.11555  ? 476 GLY B CA  1 
ATOM   1483 C C   . GLY B 2 144 ? 20.60176 -8.51556  12.13064  1.000 61.10500  ? 476 GLY B C   1 
ATOM   1484 O O   . GLY B 2 144 ? 21.28030 -8.08556  11.19295  1.000 59.24359  ? 476 GLY B O   1 
ATOM   1485 N N   . SER B 2 145 ? 20.09986 -7.72513  13.07787  1.000 64.17494  ? 477 SER B N   1 
ATOM   1486 C CA  . SER B 2 145 ? 20.32092 -6.28559  13.08920  1.000 58.28834  ? 477 SER B CA  1 
ATOM   1487 C C   . SER B 2 145 ? 21.59204 -5.88812  13.82607  1.000 56.77477  ? 477 SER B C   1 
ATOM   1488 O O   . SER B 2 145 ? 21.84918 -4.69082  13.98537  1.000 58.37559  ? 477 SER B O   1 
ATOM   1489 C CB  . SER B 2 145 ? 19.11940 -5.57177  13.71507  1.000 58.90742  ? 477 SER B CB  1 
ATOM   1490 O OG  . SER B 2 145 ? 18.92847 -5.98096  15.05761  1.000 71.94616  ? 477 SER B OG  1 
ATOM   1491 N N   . THR B 2 146 ? 22.39043 -6.85516  14.27142  1.000 55.74886  ? 478 THR B N   1 
ATOM   1492 C CA  . THR B 2 146 ? 23.61382 -6.56049  15.00444  1.000 60.23343  ? 478 THR B CA  1 
ATOM   1493 C C   . THR B 2 146 ? 24.77824 -6.42383  14.03334  1.000 57.30375  ? 478 THR B C   1 
ATOM   1494 O O   . THR B 2 146 ? 25.07864 -7.38247  13.30893  1.000 57.98060  ? 478 THR B O   1 
ATOM   1495 C CB  . THR B 2 146 ? 23.91193 -7.65631  16.01387  1.000 58.04363  ? 478 THR B CB  1 
ATOM   1496 O OG1 . THR B 2 146 ? 22.85678 -7.71681  16.98151  1.000 63.21483  ? 478 THR B OG1 1 
ATOM   1497 C CG2 . THR B 2 146 ? 25.23348 -7.38508  16.72319  1.000 62.97437  ? 478 THR B CG2 1 
ATOM   1498 N N   . PRO B 2 147 ? 25.44520 -5.27103  13.97191  1.000 58.24867  ? 479 PRO B N   1 
ATOM   1499 C CA  . PRO B 2 147 ? 26.64197 -5.15937  13.12920  1.000 56.97457  ? 479 PRO B CA  1 
ATOM   1500 C C   . PRO B 2 147 ? 27.72841 -6.11563  13.59897  1.000 56.46264  ? 479 PRO B C   1 
ATOM   1501 O O   . PRO B 2 147 ? 27.95070 -6.29362  14.79880  1.000 53.60426  ? 479 PRO B O   1 
ATOM   1502 C CB  . PRO B 2 147 ? 27.06215 -3.69512  13.30027  1.000 56.64965  ? 479 PRO B CB  1 
ATOM   1503 C CG  . PRO B 2 147 ? 25.81638 -2.99256  13.73551  1.000 57.03881  ? 479 PRO B CG  1 
ATOM   1504 C CD  . PRO B 2 147 ? 25.07374 -3.98240  14.57914  1.000 57.21427  ? 479 PRO B CD  1 
ATOM   1505 N N   . CYS B 2 148 ? 28.41002 -6.73300  12.63492  1.000 46.86190  ? 480 CYS B N   1 
ATOM   1506 C CA  . CYS B 2 148 ? 29.34939 -7.80454  12.94115  1.000 50.26288  ? 480 CYS B CA  1 
ATOM   1507 C C   . CYS B 2 148 ? 30.78546 -7.32548  13.08577  1.000 50.09232  ? 480 CYS B C   1 
ATOM   1508 O O   . CYS B 2 148 ? 31.57020 -7.96444  13.79699  1.000 51.46099  ? 480 CYS B O   1 
ATOM   1509 C CB  . CYS B 2 148 ? 29.27402 -8.88635  11.86221  1.000 53.41897  ? 480 CYS B CB  1 
ATOM   1510 S SG  . CYS B 2 148 ? 27.65560 -9.67162  11.77387  1.000 55.88760  ? 480 CYS B SG  1 
ATOM   1511 N N   . ASN B 2 149 ? 31.15140 -6.23117  12.41958  1.000 49.77060  ? 481 ASN B N   1 
ATOM   1512 C CA  . ASN B 2 149 ? 32.47543 -5.62162  12.53604  1.000 55.95518  ? 481 ASN B CA  1 
ATOM   1513 C C   . ASN B 2 149 ? 33.59796 -6.56542  12.11094  1.000 53.24782  ? 481 ASN B C   1 
ATOM   1514 O O   . ASN B 2 149 ? 34.76066 -6.35067  12.46821  1.000 55.11214  ? 481 ASN B O   1 
ATOM   1515 C CB  . ASN B 2 149 ? 32.72668 -5.11795  13.96385  1.000 50.77716  ? 481 ASN B CB  1 
ATOM   1516 C CG  . ASN B 2 149 ? 31.57772 -4.28825  14.49832  1.000 48.53783  ? 481 ASN B CG  1 
ATOM   1517 O OD1 . ASN B 2 149 ? 30.98701 -3.48448  13.77588  1.000 49.70288  ? 481 ASN B OD1 1 
ATOM   1518 N ND2 . ASN B 2 149 ? 31.24958 -4.48423  15.76875  1.000 46.26342  ? 481 ASN B ND2 1 
ATOM   1519 N N   . GLY B 2 150 ? 33.27672 -7.61390  11.35707  1.000 56.03328  ? 482 GLY B N   1 
ATOM   1520 C CA  . GLY B 2 150 ? 34.29183 -8.53607  10.89135  1.000 48.84467  ? 482 GLY B CA  1 
ATOM   1521 C C   . GLY B 2 150 ? 34.67726 -9.62391  11.86501  1.000 52.70005  ? 482 GLY B C   1 
ATOM   1522 O O   . GLY B 2 150 ? 35.71198 -10.26826 11.67298  1.000 54.20744  ? 482 GLY B O   1 
ATOM   1523 N N   . VAL B 2 151 ? 33.88362 -9.85004  12.91235  1.000 51.67492  ? 483 VAL B N   1 
ATOM   1524 C CA  . VAL B 2 151 ? 34.14721 -10.91244 13.87100  1.000 50.23596  ? 483 VAL B CA  1 
ATOM   1525 C C   . VAL B 2 151 ? 32.88192 -11.73784 14.06026  1.000 48.49262  ? 483 VAL B C   1 
ATOM   1526 O O   . VAL B 2 151 ? 31.76408 -11.28140 13.80937  1.000 47.33623  ? 483 VAL B O   1 
ATOM   1527 C CB  . VAL B 2 151 ? 34.64518 -10.37469 15.23262  1.000 50.18552  ? 483 VAL B CB  1 
ATOM   1528 C CG1 . VAL B 2 151 ? 35.99177 -9.68422  15.07563  1.000 50.70693  ? 483 VAL B CG1 1 
ATOM   1529 C CG2 . VAL B 2 151 ? 33.62101 -9.43355  15.84384  1.000 51.19737  ? 483 VAL B CG2 1 
ATOM   1530 N N   . GLU B 2 152 ? 33.08003 -12.97480 14.50566  1.000 46.49295  ? 484 GLU B N   1 
ATOM   1531 C CA  . GLU B 2 152 ? 31.97342 -13.87135 14.80129  1.000 46.78842  ? 484 GLU B CA  1 
ATOM   1532 C C   . GLU B 2 152 ? 31.36878 -13.53850 16.15851  1.000 49.06397  ? 484 GLU B C   1 
ATOM   1533 O O   . GLU B 2 152 ? 32.08586 -13.23573 17.11626  1.000 54.13600  ? 484 GLU B O   1 
ATOM   1534 C CB  . GLU B 2 152 ? 32.44809 -15.32440 14.78521  1.000 45.60241  ? 484 GLU B CB  1 
ATOM   1535 C CG  . GLU B 2 152 ? 32.81366 -15.84783 13.40802  1.000 46.93719  ? 484 GLU B CG  1 
ATOM   1536 C CD  . GLU B 2 152 ? 33.77130 -17.02150 13.46809  1.000 48.96841  ? 484 GLU B CD  1 
ATOM   1537 O OE1 . GLU B 2 152 ? 34.98308 -16.79037 13.66240  1.000 47.91990  ? 484 GLU B OE1 1 
ATOM   1538 O OE2 . GLU B 2 152 ? 33.31303 -18.17550 13.33077  1.000 52.23880  ? 484 GLU B OE2 1 
ATOM   1539 N N   . GLY B 2 153 ? 30.04150 -13.59928 16.23702  1.000 49.02389  ? 485 GLY B N   1 
ATOM   1540 C CA  . GLY B 2 153 ? 29.34675 -13.32679 17.47941  1.000 43.39853  ? 485 GLY B CA  1 
ATOM   1541 C C   . GLY B 2 153 ? 27.85905 -13.60167 17.41071  1.000 50.61691  ? 485 GLY B C   1 
ATOM   1542 O O   . GLY B 2 153 ? 27.42208 -14.54329 16.74097  1.000 45.73549  ? 485 GLY B O   1 
ATOM   1543 N N   . PHE B 2 154 ? 27.07195 -12.78430 18.10593  1.000 48.83456  ? 486 PHE B N   1 
ATOM   1544 C CA  . PHE B 2 154 ? 25.62199 -12.93292 18.09710  1.000 49.32896  ? 486 PHE B CA  1 
ATOM   1545 C C   . PHE B 2 154 ? 25.07261 -12.59793 16.71316  1.000 48.44158  ? 486 PHE B C   1 
ATOM   1546 O O   . PHE B 2 154 ? 25.20278 -11.46165 16.24664  1.000 47.76744  ? 486 PHE B O   1 
ATOM   1547 C CB  . PHE B 2 154 ? 25.00079 -12.03098 19.16122  1.000 46.58366  ? 486 PHE B CB  1 
ATOM   1548 C CG  . PHE B 2 154 ? 23.51757 -12.20691 19.31755  1.000 50.46825  ? 486 PHE B CG  1 
ATOM   1549 C CD1 . PHE B 2 154 ? 23.00715 -13.26329 20.05352  1.000 48.11927  ? 486 PHE B CD1 1 
ATOM   1550 C CD2 . PHE B 2 154 ? 22.63302 -11.31015 18.73924  1.000 50.02179  ? 486 PHE B CD2 1 
ATOM   1551 C CE1 . PHE B 2 154 ? 21.64364 -13.42868 20.20253  1.000 46.81360  ? 486 PHE B CE1 1 
ATOM   1552 C CE2 . PHE B 2 154 ? 21.26604 -11.46965 18.88648  1.000 47.80077  ? 486 PHE B CE2 1 
ATOM   1553 C CZ  . PHE B 2 154 ? 20.77192 -12.53164 19.61792  1.000 47.31837  ? 486 PHE B CZ  1 
ATOM   1554 N N   . ASN B 2 155 ? 24.45625 -13.58941 16.06242  1.000 49.05602  ? 487 ASN B N   1 
ATOM   1555 C CA  . ASN B 2 155 ? 23.91828 -13.45318 14.70443  1.000 50.08160  ? 487 ASN B CA  1 
ATOM   1556 C C   . ASN B 2 155 ? 24.98563 -13.00715 13.70967  1.000 48.12180  ? 487 ASN B C   1 
ATOM   1557 O O   . ASN B 2 155 ? 24.68878 -12.32345 12.72726  1.000 47.62509  ? 487 ASN B O   1 
ATOM   1558 C CB  . ASN B 2 155 ? 22.72535 -12.49315 14.65812  1.000 48.75787  ? 487 ASN B CB  1 
ATOM   1559 C CG  . ASN B 2 155 ? 21.54121 -12.99147 15.45611  1.000 50.32615  ? 487 ASN B CG  1 
ATOM   1560 O OD1 . ASN B 2 155 ? 20.71010 -12.20374 15.89703  1.000 51.60533  ? 487 ASN B OD1 1 
ATOM   1561 N ND2 . ASN B 2 155 ? 21.46040 -14.30285 15.65099  1.000 46.78420  ? 487 ASN B ND2 1 
ATOM   1562 N N   . CYS B 2 156 ? 26.23496 -13.39065 13.95976  1.000 48.38131  ? 488 CYS B N   1 
ATOM   1563 C CA  . CYS B 2 156 ? 27.36838 -13.04236 13.10573  1.000 44.94866  ? 488 CYS B CA  1 
ATOM   1564 C C   . CYS B 2 156 ? 28.17776 -14.32085 12.92222  1.000 48.35326  ? 488 CYS B C   1 
ATOM   1565 O O   . CYS B 2 156 ? 29.02742 -14.65391 13.75324  1.000 52.26207  ? 488 CYS B O   1 
ATOM   1566 C CB  . CYS B 2 156 ? 28.19160 -11.91633 13.71941  1.000 44.15953  ? 488 CYS B CB  1 
ATOM   1567 S SG  . CYS B 2 156 ? 27.35405 -10.31331 13.68187  1.000 49.75341  ? 488 CYS B SG  1 
ATOM   1568 N N   . TYR B 2 157 ? 27.90262 -15.04012 11.83836  1.000 47.16925  ? 489 TYR B N   1 
ATOM   1569 C CA  . TYR B 2 157 ? 28.40163 -16.39282 11.64712  1.000 46.07936  ? 489 TYR B CA  1 
ATOM   1570 C C   . TYR B 2 157 ? 29.38519 -16.44566 10.48865  1.000 47.94008  ? 489 TYR B C   1 
ATOM   1571 O O   . TYR B 2 157 ? 29.20563 -15.76333 9.47474   1.000 46.44245  ? 489 TYR B O   1 
ATOM   1572 C CB  . TYR B 2 157 ? 27.24987 -17.36785 11.38186  1.000 41.92692  ? 489 TYR B CB  1 
ATOM   1573 C CG  . TYR B 2 157 ? 26.07287 -17.18995 12.31006  1.000 43.81421  ? 489 TYR B CG  1 
ATOM   1574 C CD1 . TYR B 2 157 ? 26.17884 -17.49648 13.66241  1.000 44.54911  ? 489 TYR B CD1 1 
ATOM   1575 C CD2 . TYR B 2 157 ? 24.85446 -16.71973 11.83670  1.000 38.77971  ? 489 TYR B CD2 1 
ATOM   1576 C CE1 . TYR B 2 157 ? 25.10667 -17.33592 14.51805  1.000 41.94109  ? 489 TYR B CE1 1 
ATOM   1577 C CE2 . TYR B 2 157 ? 23.77460 -16.55831 12.68408  1.000 43.55186  ? 489 TYR B CE2 1 
ATOM   1578 C CZ  . TYR B 2 157 ? 23.90841 -16.86805 14.02579  1.000 45.15196  ? 489 TYR B CZ  1 
ATOM   1579 O OH  . TYR B 2 157 ? 22.84392 -16.70849 14.88084  1.000 46.13829  ? 489 TYR B OH  1 
ATOM   1580 N N   . PHE B 2 158 ? 30.42364 -17.25476 10.65249  1.000 47.23214  ? 490 PHE B N   1 
ATOM   1581 C CA  . PHE B 2 158 ? 31.28376 -17.59137 9.53353   1.000 42.61755  ? 490 PHE B CA  1 
ATOM   1582 C C   . PHE B 2 158 ? 30.43487 -18.26743 8.46211   1.000 46.30595  ? 490 PHE B C   1 
ATOM   1583 O O   . PHE B 2 158 ? 29.73574 -19.24605 8.76104   1.000 47.03423  ? 490 PHE B O   1 
ATOM   1584 C CB  . PHE B 2 158 ? 32.41470 -18.51211 9.99010   1.000 45.84922  ? 490 PHE B CB  1 
ATOM   1585 C CG  . PHE B 2 158 ? 33.55264 -18.60767 9.01685   1.000 49.18524  ? 490 PHE B CG  1 
ATOM   1586 C CD1 . PHE B 2 158 ? 34.47236 -17.57818 8.90618   1.000 48.85796  ? 490 PHE B CD1 1 
ATOM   1587 C CD2 . PHE B 2 158 ? 33.71208 -19.73104 8.22271   1.000 45.65995  ? 490 PHE B CD2 1 
ATOM   1588 C CE1 . PHE B 2 158 ? 35.52408 -17.66204 8.01317   1.000 51.39954  ? 490 PHE B CE1 1 
ATOM   1589 C CE2 . PHE B 2 158 ? 34.76310 -19.82161 7.32846   1.000 50.16617  ? 490 PHE B CE2 1 
ATOM   1590 C CZ  . PHE B 2 158 ? 35.66963 -18.78507 7.22348   1.000 52.92456  ? 490 PHE B CZ  1 
ATOM   1591 N N   . PRO B 2 159 ? 30.44767 -17.77529 7.22163   1.000 46.90482  ? 491 PRO B N   1 
ATOM   1592 C CA  . PRO B 2 159 ? 29.47904 -18.26880 6.22864   1.000 42.87094  ? 491 PRO B CA  1 
ATOM   1593 C C   . PRO B 2 159 ? 29.65205 -19.73443 5.88107   1.000 39.45923  ? 491 PRO B C   1 
ATOM   1594 O O   . PRO B 2 159 ? 28.68669 -20.36726 5.43642   1.000 40.43839  ? 491 PRO B O   1 
ATOM   1595 C CB  . PRO B 2 159 ? 29.73673 -17.36842 5.01373   1.000 40.82050  ? 491 PRO B CB  1 
ATOM   1596 C CG  . PRO B 2 159 ? 31.15762 -16.94629 5.16138   1.000 40.03212  ? 491 PRO B CG  1 
ATOM   1597 C CD  . PRO B 2 159 ? 31.39385 -16.80739 6.64157   1.000 46.67028  ? 491 PRO B CD  1 
ATOM   1598 N N   . LEU B 2 160 ? 30.83660 -20.29822 6.08100   1.000 39.31040  ? 492 LEU B N   1 
ATOM   1599 C CA  . LEU B 2 160 ? 31.10648 -21.68505 5.74081   1.000 38.46638  ? 492 LEU B CA  1 
ATOM   1600 C C   . LEU B 2 160 ? 30.96499 -22.57353 6.96759   1.000 42.93907  ? 492 LEU B C   1 
ATOM   1601 O O   . LEU B 2 160 ? 31.39446 -22.21036 8.06616   1.000 46.34730  ? 492 LEU B O   1 
ATOM   1602 C CB  . LEU B 2 160 ? 32.51060 -21.83619 5.15820   1.000 44.00957  ? 492 LEU B CB  1 
ATOM   1603 C CG  . LEU B 2 160 ? 32.84579 -20.94008 3.96816   1.000 46.13394  ? 492 LEU B CG  1 
ATOM   1604 C CD1 . LEU B 2 160 ? 34.27670 -21.18383 3.52154   1.000 37.14328  ? 492 LEU B CD1 1 
ATOM   1605 C CD2 . LEU B 2 160 ? 31.86503 -21.16905 2.82783   1.000 36.15450  ? 492 LEU B CD2 1 
ATOM   1606 N N   . GLN B 2 161 ? 30.35396 -23.73607 6.77073   1.000 43.57072  ? 493 GLN B N   1 
ATOM   1607 C CA  . GLN B 2 161 ? 30.30967 -24.79314 7.76795   1.000 43.17754  ? 493 GLN B CA  1 
ATOM   1608 C C   . GLN B 2 161 ? 30.91445 -26.05028 7.16695   1.000 40.44964  ? 493 GLN B C   1 
ATOM   1609 O O   . GLN B 2 161 ? 30.72730 -26.33359 5.98100   1.000 49.42879  ? 493 GLN B O   1 
ATOM   1610 C CB  . GLN B 2 161 ? 28.87916 -25.06908 8.24295   1.000 43.67249  ? 493 GLN B CB  1 
ATOM   1611 C CG  . GLN B 2 161 ? 28.51409 -24.35671 9.53249   1.000 51.22215  ? 493 GLN B CG  1 
ATOM   1612 C CD  . GLN B 2 161 ? 29.41880 -24.74959 10.68521  1.000 52.09873  ? 493 GLN B CD  1 
ATOM   1613 O OE1 . GLN B 2 161 ? 30.16431 -23.92374 11.21159  1.000 54.04206  ? 493 GLN B OE1 1 
ATOM   1614 N NE2 . GLN B 2 161 ? 29.35863 -26.01727 11.08214  1.000 47.01522  ? 493 GLN B NE2 1 
ATOM   1615 N N   . SER B 2 162 ? 31.64763 -26.79412 7.97971   1.000 44.09701  ? 494 SER B N   1 
ATOM   1616 C CA  . SER B 2 162 ? 32.32113 -27.98790 7.50162   1.000 43.27611  ? 494 SER B CA  1 
ATOM   1617 C C   . SER B 2 162 ? 31.40110 -29.19808 7.58874   1.000 41.09632  ? 494 SER B C   1 
ATOM   1618 O O   . SER B 2 162 ? 30.56719 -29.31012 8.49178   1.000 45.31874  ? 494 SER B O   1 
ATOM   1619 C CB  . SER B 2 162 ? 33.59732 -28.24422 8.30190   1.000 46.04137  ? 494 SER B CB  1 
ATOM   1620 O OG  . SER B 2 162 ? 34.30227 -29.34973 7.77213   1.000 53.47899  ? 494 SER B OG  1 
ATOM   1621 N N   . TYR B 2 163 ? 31.55236 -30.09899 6.62414   1.000 41.33305  ? 495 TYR B N   1 
ATOM   1622 C CA  . TYR B 2 163 ? 30.85124 -31.37124 6.67326   1.000 43.20815  ? 495 TYR B CA  1 
ATOM   1623 C C   . TYR B 2 163 ? 31.45186 -32.26251 7.75321   1.000 45.80538  ? 495 TYR B C   1 
ATOM   1624 O O   . TYR B 2 163 ? 32.65261 -32.21590 8.03298   1.000 45.57566  ? 495 TYR B O   1 
ATOM   1625 C CB  . TYR B 2 163 ? 30.93130 -32.08992 5.32671   1.000 44.64877  ? 495 TYR B CB  1 
ATOM   1626 C CG  . TYR B 2 163 ? 30.03089 -31.54994 4.23577   1.000 44.56789  ? 495 TYR B CG  1 
ATOM   1627 C CD1 . TYR B 2 163 ? 28.64886 -31.64334 4.33696   1.000 41.28604  ? 495 TYR B CD1 1 
ATOM   1628 C CD2 . TYR B 2 163 ? 30.56597 -30.98365 3.08561   1.000 42.76694  ? 495 TYR B CD2 1 
ATOM   1629 C CE1 . TYR B 2 163 ? 27.82440 -31.16316 3.33494   1.000 42.41756  ? 495 TYR B CE1 1 
ATOM   1630 C CE2 . TYR B 2 163 ? 29.74937 -30.50606 2.07442   1.000 46.55821  ? 495 TYR B CE2 1 
ATOM   1631 C CZ  . TYR B 2 163 ? 28.38011 -30.59922 2.20500   1.000 46.26932  ? 495 TYR B CZ  1 
ATOM   1632 O OH  . TYR B 2 163 ? 27.56413 -30.12305 1.20704   1.000 37.45857  ? 495 TYR B OH  1 
ATOM   1633 N N   . GLY B 2 164 ? 30.60312 -33.08940 8.35480   1.000 44.64232  ? 496 GLY B N   1 
ATOM   1634 C CA  . GLY B 2 164 ? 31.06386 -34.04496 9.34209   1.000 50.54817  ? 496 GLY B CA  1 
ATOM   1635 C C   . GLY B 2 164 ? 31.16023 -35.44258 8.76989   1.000 47.07383  ? 496 GLY B C   1 
ATOM   1636 O O   . GLY B 2 164 ? 30.32313 -36.30136 9.06180   1.000 49.60674  ? 496 GLY B O   1 
ATOM   1637 N N   . PHE B 2 165 ? 32.17834 -35.68256 7.94932   1.000 44.55141  ? 497 PHE B N   1 
ATOM   1638 C CA  . PHE B 2 165 ? 32.30154 -36.93718 7.21090   1.000 49.31044  ? 497 PHE B CA  1 
ATOM   1639 C C   . PHE B 2 165 ? 33.01430 -37.96039 8.08524   1.000 53.84004  ? 497 PHE B C   1 
ATOM   1640 O O   . PHE B 2 165 ? 34.23790 -37.92766 8.23697   1.000 51.91607  ? 497 PHE B O   1 
ATOM   1641 C CB  . PHE B 2 165 ? 33.02922 -36.71162 5.89047   1.000 52.15990  ? 497 PHE B CB  1 
ATOM   1642 C CG  . PHE B 2 165 ? 32.19867 -36.00024 4.86114   1.000 46.48956  ? 497 PHE B CG  1 
ATOM   1643 C CD1 . PHE B 2 165 ? 30.83200 -36.21602 4.79122   1.000 47.07042  ? 497 PHE B CD1 1 
ATOM   1644 C CD2 . PHE B 2 165 ? 32.77767 -35.10969 3.97366   1.000 45.28800  ? 497 PHE B CD2 1 
ATOM   1645 C CE1 . PHE B 2 165 ? 30.05887 -35.56342 3.84939   1.000 51.49838  ? 497 PHE B CE1 1 
ATOM   1646 C CE2 . PHE B 2 165 ? 32.01000 -34.45254 3.02772   1.000 45.76074  ? 497 PHE B CE2 1 
ATOM   1647 C CZ  . PHE B 2 165 ? 30.64947 -34.68041 2.96472   1.000 47.72294  ? 497 PHE B CZ  1 
ATOM   1648 N N   . GLN B 2 166 ? 32.23723 -38.87347 8.66409   1.000 54.63543  ? 498 GLN B N   1 
ATOM   1649 C CA  . GLN B 2 166 ? 32.72924 -39.98839 9.44662   1.000 53.06616  ? 498 GLN B CA  1 
ATOM   1650 C C   . GLN B 2 166 ? 32.31244 -41.29617 8.78805   1.000 54.64771  ? 498 GLN B C   1 
ATOM   1651 O O   . GLN B 2 166 ? 31.17219 -41.41519 8.32698   1.000 52.95842  ? 498 GLN B O   1 
ATOM   1652 C CB  . GLN B 2 166 ? 32.18189 -39.93973 10.87965  1.000 52.97020  ? 498 GLN B CB  1 
ATOM   1653 C CG  . GLN B 2 166 ? 32.35244 -38.59419 11.55284  1.000 54.21804  ? 498 GLN B CG  1 
ATOM   1654 C CD  . GLN B 2 166 ? 31.66930 -38.52308 12.90036  1.000 61.49146  ? 498 GLN B CD  1 
ATOM   1655 O OE1 . GLN B 2 166 ? 30.85888 -39.38379 13.24648  1.000 60.43882  ? 498 GLN B OE1 1 
ATOM   1656 N NE2 . GLN B 2 166 ? 31.99159 -37.49110 13.67050  1.000 59.33958  ? 498 GLN B NE2 1 
ATOM   1657 N N   . PRO B 2 167 ? 33.20388 -42.28819 8.72094   1.000 57.34901  ? 499 PRO B N   1 
ATOM   1658 C CA  . PRO B 2 167 ? 32.83935 -43.55532 8.06373   1.000 54.02001  ? 499 PRO B CA  1 
ATOM   1659 C C   . PRO B 2 167 ? 31.62052 -44.22924 8.67233   1.000 57.37878  ? 499 PRO B C   1 
ATOM   1660 O O   . PRO B 2 167 ? 30.98911 -45.05502 7.99991   1.000 61.14013  ? 499 PRO B O   1 
ATOM   1661 C CB  . PRO B 2 167 ? 34.10270 -44.41449 8.22606   1.000 51.39997  ? 499 PRO B CB  1 
ATOM   1662 C CG  . PRO B 2 167 ? 34.87873 -43.76812 9.33318   1.000 59.48937  ? 499 PRO B CG  1 
ATOM   1663 C CD  . PRO B 2 167 ? 34.58183 -42.30572 9.23747   1.000 60.32504  ? 499 PRO B CD  1 
ATOM   1664 N N   . THR B 2 168 ? 31.26198 -43.89425 9.91344   1.000 49.75412  ? 500 THR B N   1 
ATOM   1665 C CA  . THR B 2 168 ? 30.06497 -44.42727 10.54911  1.000 48.12441  ? 500 THR B CA  1 
ATOM   1666 C C   . THR B 2 168 ? 28.78315 -43.79766 10.01974  1.000 51.22320  ? 500 THR B C   1 
ATOM   1667 O O   . THR B 2 168 ? 27.69917 -44.33151 10.27943  1.000 53.45320  ? 500 THR B O   1 
ATOM   1668 C CB  . THR B 2 168 ? 30.13651 -44.21678 12.06623  1.000 51.68645  ? 500 THR B CB  1 
ATOM   1669 O OG1 . THR B 2 168 ? 31.50300 -44.26281 12.49591  1.000 50.57432  ? 500 THR B OG1 1 
ATOM   1670 C CG2 . THR B 2 168 ? 29.35069 -45.29792 12.79241  1.000 50.13230  ? 500 THR B CG2 1 
ATOM   1671 N N   . ASN B 2 169 ? 28.87947 -42.68337 9.29654   1.000 49.97503  ? 501 ASN B N   1 
ATOM   1672 C CA  . ASN B 2 169 ? 27.69351 -41.99605 8.80399   1.000 54.63096  ? 501 ASN B CA  1 
ATOM   1673 C C   . ASN B 2 169 ? 26.87672 -42.89625 7.88558   1.000 49.38128  ? 501 ASN B C   1 
ATOM   1674 O O   . ASN B 2 169 ? 27.40556 -43.79048 7.22044   1.000 50.16970  ? 501 ASN B O   1 
ATOM   1675 C CB  . ASN B 2 169 ? 28.08620 -40.72672 8.04661   1.000 54.68608  ? 501 ASN B CB  1 
ATOM   1676 C CG  . ASN B 2 169 ? 28.70091 -39.67861 8.94416   1.000 51.15191  ? 501 ASN B CG  1 
ATOM   1677 O OD1 . ASN B 2 169 ? 28.85591 -39.88857 10.14662  1.000 50.71079  ? 501 ASN B OD1 1 
ATOM   1678 N ND2 . ASN B 2 169 ? 29.06302 -38.54071 8.36133   1.000 45.33095  ? 501 ASN B ND2 1 
ATOM   1679 N N   . GLY B 2 170 ? 25.56735 -42.65506 7.86409   1.000 46.86942  ? 502 GLY B N   1 
ATOM   1680 C CA  . GLY B 2 170 ? 24.73106 -43.24798 6.84612   1.000 45.83969  ? 502 GLY B CA  1 
ATOM   1681 C C   . GLY B 2 170 ? 25.02560 -42.66287 5.47967   1.000 49.59176  ? 502 GLY B C   1 
ATOM   1682 O O   . GLY B 2 170 ? 25.62260 -41.59386 5.34837   1.000 48.95685  ? 502 GLY B O   1 
ATOM   1683 N N   . VAL B 2 171 ? 24.58563 -43.38072 4.44124   1.000 47.57079  ? 503 VAL B N   1 
ATOM   1684 C CA  . VAL B 2 171 ? 24.95758 -43.02174 3.07315   1.000 51.19273  ? 503 VAL B CA  1 
ATOM   1685 C C   . VAL B 2 171 ? 24.49411 -41.61442 2.71839   1.000 49.90951  ? 503 VAL B C   1 
ATOM   1686 O O   . VAL B 2 171 ? 25.10456 -40.94919 1.87291   1.000 53.46335  ? 503 VAL B O   1 
ATOM   1687 C CB  . VAL B 2 171 ? 24.40998 -44.06345 2.07609   1.000 51.04155  ? 503 VAL B CB  1 
ATOM   1688 C CG1 . VAL B 2 171 ? 25.10252 -45.40265 2.27694   1.000 49.69439  ? 503 VAL B CG1 1 
ATOM   1689 C CG2 . VAL B 2 171 ? 22.90252 -44.20699 2.22324   1.000 43.74484  ? 503 VAL B CG2 1 
ATOM   1690 N N   . GLY B 2 172 ? 23.42241 -41.13349 3.35297   1.000 49.22810  ? 504 GLY B N   1 
ATOM   1691 C CA  . GLY B 2 172 ? 22.96285 -39.78058 3.09079   1.000 41.09028  ? 504 GLY B CA  1 
ATOM   1692 C C   . GLY B 2 172 ? 23.89635 -38.71633 3.63013   1.000 44.97359  ? 504 GLY B C   1 
ATOM   1693 O O   . GLY B 2 172 ? 23.94401 -37.60142 3.10200   1.000 45.60500  ? 504 GLY B O   1 
ATOM   1694 N N   . TYR B 2 173 ? 24.64044 -39.03481 4.68632   1.000 48.01321  ? 505 TYR B N   1 
ATOM   1695 C CA  . TYR B 2 173 ? 25.63382 -38.13361 5.24938   1.000 47.03041  ? 505 TYR B CA  1 
ATOM   1696 C C   . TYR B 2 173 ? 27.05153 -38.52427 4.85923   1.000 47.22209  ? 505 TYR B C   1 
ATOM   1697 O O   . TYR B 2 173 ? 28.00975 -37.92030 5.35024   1.000 49.43195  ? 505 TYR B O   1 
ATOM   1698 C CB  . TYR B 2 173 ? 25.49806 -38.08231 6.77356   1.000 47.98656  ? 505 TYR B CB  1 
ATOM   1699 C CG  . TYR B 2 173 ? 24.18612 -37.49320 7.24406   1.000 48.87944  ? 505 TYR B CG  1 
ATOM   1700 C CD1 . TYR B 2 173 ? 24.00426 -36.11742 7.30724   1.000 49.86912  ? 505 TYR B CD1 1 
ATOM   1701 C CD2 . TYR B 2 173 ? 23.12880 -38.31060 7.62085   1.000 46.53691  ? 505 TYR B CD2 1 
ATOM   1702 C CE1 . TYR B 2 173 ? 22.80720 -35.57102 7.73420   1.000 43.51487  ? 505 TYR B CE1 1 
ATOM   1703 C CE2 . TYR B 2 173 ? 21.92617 -37.77287 8.04918   1.000 43.90992  ? 505 TYR B CE2 1 
ATOM   1704 C CZ  . TYR B 2 173 ? 21.77152 -36.40240 8.10245   1.000 43.77294  ? 505 TYR B CZ  1 
ATOM   1705 O OH  . TYR B 2 173 ? 20.57942 -35.85918 8.52731   1.000 43.70215  ? 505 TYR B OH  1 
ATOM   1706 N N   . GLN B 2 174 ? 27.20474 -39.52213 3.99357   1.000 49.53634  ? 506 GLN B N   1 
ATOM   1707 C CA  . GLN B 2 174 ? 28.51800 -39.89998 3.50464   1.000 48.54456  ? 506 GLN B CA  1 
ATOM   1708 C C   . GLN B 2 174 ? 28.95003 -38.96770 2.37465   1.000 42.49329  ? 506 GLN B C   1 
ATOM   1709 O O   . GLN B 2 174 ? 28.11084 -38.43242 1.64565   1.000 41.54949  ? 506 GLN B O   1 
ATOM   1710 C CB  . GLN B 2 174 ? 28.51153 -41.34526 3.01637   1.000 49.15986  ? 506 GLN B CB  1 
ATOM   1711 C CG  . GLN B 2 174 ? 28.44946 -42.36908 4.14026   1.000 51.77556  ? 506 GLN B CG  1 
ATOM   1712 C CD  . GLN B 2 174 ? 28.43764 -43.79734 3.63517   1.000 53.47717  ? 506 GLN B CD  1 
ATOM   1713 O OE1 . GLN B 2 174 ? 28.90190 -44.08232 2.53177   1.000 52.76992  ? 506 GLN B OE1 1 
ATOM   1714 N NE2 . GLN B 2 174 ? 27.89970 -44.70458 4.44151   1.000 52.10427  ? 506 GLN B NE2 1 
ATOM   1715 N N   . PRO B 2 175 ? 30.25330 -38.74485 2.22102   1.000 46.92483  ? 507 PRO B N   1 
ATOM   1716 C CA  . PRO B 2 175 ? 30.72130 -37.85447 1.15364   1.000 44.48369  ? 507 PRO B CA  1 
ATOM   1717 C C   . PRO B 2 175 ? 30.52284 -38.48088 -0.21682  1.000 44.84326  ? 507 PRO B C   1 
ATOM   1718 O O   . PRO B 2 175 ? 30.75087 -39.67680 -0.41325  1.000 49.09642  ? 507 PRO B O   1 
ATOM   1719 C CB  . PRO B 2 175 ? 32.20778 -37.66896 1.47443   1.000 46.30972  ? 507 PRO B CB  1 
ATOM   1720 C CG  . PRO B 2 175 ? 32.57806 -38.90574 2.22742   1.000 51.32991  ? 507 PRO B CG  1 
ATOM   1721 C CD  . PRO B 2 175 ? 31.36519 -39.27561 3.02947   1.000 46.74052  ? 507 PRO B CD  1 
ATOM   1722 N N   . TYR B 2 176 ? 30.08565 -37.65561 -1.16565  1.000 42.87461  ? 508 TYR B N   1 
ATOM   1723 C CA  . TYR B 2 176 ? 29.89981 -38.06443 -2.55196  1.000 44.93593  ? 508 TYR B CA  1 
ATOM   1724 C C   . TYR B 2 176 ? 30.67887 -37.12141 -3.45246  1.000 43.46456  ? 508 TYR B C   1 
ATOM   1725 O O   . TYR B 2 176 ? 30.56525 -35.89866 -3.32073  1.000 42.79334  ? 508 TYR B O   1 
ATOM   1726 C CB  . TYR B 2 176 ? 28.41822 -38.05999 -2.94694  1.000 43.11032  ? 508 TYR B CB  1 
ATOM   1727 C CG  . TYR B 2 176 ? 27.71790 -39.38452 -2.74952  1.000 46.52227  ? 508 TYR B CG  1 
ATOM   1728 C CD1 . TYR B 2 176 ? 27.47267 -39.88090 -1.47553  1.000 47.29673  ? 508 TYR B CD1 1 
ATOM   1729 C CD2 . TYR B 2 176 ? 27.29232 -40.13433 -3.83735  1.000 45.20368  ? 508 TYR B CD2 1 
ATOM   1730 C CE1 . TYR B 2 176 ? 26.82958 -41.09065 -1.29118  1.000 48.69523  ? 508 TYR B CE1 1 
ATOM   1731 C CE2 . TYR B 2 176 ? 26.64750 -41.34492 -3.66290  1.000 47.33166  ? 508 TYR B CE2 1 
ATOM   1732 C CZ  . TYR B 2 176 ? 26.41818 -41.81765 -2.38854  1.000 53.21149  ? 508 TYR B CZ  1 
ATOM   1733 O OH  . TYR B 2 176 ? 25.77715 -43.02148 -2.20890  1.000 58.06699  ? 508 TYR B OH  1 
ATOM   1734 N N   . ARG B 2 177 ? 31.46775 -37.68715 -4.36007  1.000 47.05567  ? 509 ARG B N   1 
ATOM   1735 C CA  . ARG B 2 177 ? 32.19525 -36.89872 -5.34397  1.000 43.85527  ? 509 ARG B CA  1 
ATOM   1736 C C   . ARG B 2 177 ? 31.33165 -36.72769 -6.58588  1.000 45.06387  ? 509 ARG B C   1 
ATOM   1737 O O   . ARG B 2 177 ? 30.84340 -37.71138 -7.14980  1.000 47.31821  ? 509 ARG B O   1 
ATOM   1738 C CB  . ARG B 2 177 ? 33.52570 -37.56382 -5.69689  1.000 45.72431  ? 509 ARG B CB  1 
ATOM   1739 C CG  . ARG B 2 177 ? 34.53704 -37.52228 -4.57032  1.000 41.51525  ? 509 ARG B CG  1 
ATOM   1740 C CD  . ARG B 2 177 ? 35.86996 -38.11444 -4.98187  1.000 47.36556  ? 509 ARG B CD  1 
ATOM   1741 N NE  . ARG B 2 177 ? 36.92286 -37.74397 -4.04432  1.000 44.52621  ? 509 ARG B NE  1 
ATOM   1742 C CZ  . ARG B 2 177 ? 38.19944 -38.07282 -4.18163  1.000 49.11067  ? 509 ARG B CZ  1 
ATOM   1743 N NH1 . ARG B 2 177 ? 38.62079 -38.79366 -5.20744  1.000 55.75744  ? 509 ARG B NH1 1 
ATOM   1744 N NH2 . ARG B 2 177 ? 39.07575 -37.66549 -3.26819  1.000 47.39929  ? 509 ARG B NH2 1 
ATOM   1745 N N   . VAL B 2 178 ? 31.14405 -35.47943 -7.00594  1.000 42.65711  ? 510 VAL B N   1 
ATOM   1746 C CA  . VAL B 2 178 ? 30.26140 -35.14016 -8.11383  1.000 36.22606  ? 510 VAL B CA  1 
ATOM   1747 C C   . VAL B 2 178 ? 31.08445 -34.49835 -9.22061  1.000 41.13441  ? 510 VAL B C   1 
ATOM   1748 O O   . VAL B 2 178 ? 31.94270 -33.65020 -8.95579  1.000 41.36417  ? 510 VAL B O   1 
ATOM   1749 C CB  . VAL B 2 178 ? 29.12870 -34.19354 -7.66457  1.000 36.59162  ? 510 VAL B CB  1 
ATOM   1750 C CG1 . VAL B 2 178 ? 28.07357 -34.06831 -8.75059  1.000 38.03978  ? 510 VAL B CG1 1 
ATOM   1751 C CG2 . VAL B 2 178 ? 28.51302 -34.67673 -6.35936  1.000 38.68578  ? 510 VAL B CG2 1 
ATOM   1752 N N   . VAL B 2 179 ? 30.82622 -34.90832 -10.45978 1.000 40.22436  ? 511 VAL B N   1 
ATOM   1753 C CA  . VAL B 2 179 ? 31.40475 -34.27622 -11.64022 1.000 40.16351  ? 511 VAL B CA  1 
ATOM   1754 C C   . VAL B 2 179 ? 30.25827 -33.83371 -12.53403 1.000 37.59247  ? 511 VAL B C   1 
ATOM   1755 O O   . VAL B 2 179 ? 29.41540 -34.65243 -12.92185 1.000 37.56376  ? 511 VAL B O   1 
ATOM   1756 C CB  . VAL B 2 179 ? 32.35985 -35.21113 -12.39790 1.000 40.96808  ? 511 VAL B CB  1 
ATOM   1757 C CG1 . VAL B 2 179 ? 32.77211 -34.57557 -13.71849 1.000 37.37445  ? 511 VAL B CG1 1 
ATOM   1758 C CG2 . VAL B 2 179 ? 33.58644 -35.51229 -11.55499 1.000 41.63236  ? 511 VAL B CG2 1 
ATOM   1759 N N   . VAL B 2 180 ? 30.22238 -32.54437 -12.85217 1.000 35.28211  ? 512 VAL B N   1 
ATOM   1760 C CA  . VAL B 2 180 ? 29.18738 -31.96246 -13.69636 1.000 35.52917  ? 512 VAL B CA  1 
ATOM   1761 C C   . VAL B 2 180 ? 29.83727 -31.58403 -15.02194 1.000 42.11419  ? 512 VAL B C   1 
ATOM   1762 O O   . VAL B 2 180 ? 30.68526 -30.68385 -15.07669 1.000 37.74291  ? 512 VAL B O   1 
ATOM   1763 C CB  . VAL B 2 180 ? 28.52532 -30.74813 -13.03193 1.000 36.32883  ? 512 VAL B CB  1 
ATOM   1764 C CG1 . VAL B 2 180 ? 27.27013 -30.34167 -13.78812 1.000 35.16389  ? 512 VAL B CG1 1 
ATOM   1765 C CG2 . VAL B 2 180 ? 28.20465 -31.05046 -11.57369 1.000 41.40396  ? 512 VAL B CG2 1 
ATOM   1766 N N   . LEU B 2 181 ? 29.44844 -32.27426 -16.09092 1.000 40.18935  ? 513 LEU B N   1 
ATOM   1767 C CA  . LEU B 2 181 ? 29.93370 -31.98730 -17.43548 1.000 40.10426  ? 513 LEU B CA  1 
ATOM   1768 C C   . LEU B 2 181 ? 28.92475 -31.09601 -18.14520 1.000 38.96875  ? 513 LEU B C   1 
ATOM   1769 O O   . LEU B 2 181 ? 27.75342 -31.46367 -18.27610 1.000 41.80458  ? 513 LEU B O   1 
ATOM   1770 C CB  . LEU B 2 181 ? 30.15276 -33.27325 -18.23053 1.000 38.14297  ? 513 LEU B CB  1 
ATOM   1771 C CG  . LEU B 2 181 ? 31.22735 -34.23571 -17.72708 1.000 42.88691  ? 513 LEU B CG  1 
ATOM   1772 C CD1 . LEU B 2 181 ? 31.27168 -35.47503 -18.60831 1.000 38.02980  ? 513 LEU B CD1 1 
ATOM   1773 C CD2 . LEU B 2 181 ? 32.58266 -33.54992 -17.68601 1.000 34.31692  ? 513 LEU B CD2 1 
ATOM   1774 N N   . SER B 2 182 ? 29.37644 -29.93013 -18.59417 1.000 35.91444  ? 514 SER B N   1 
ATOM   1775 C CA  . SER B 2 182 ? 28.54644 -29.01632 -19.36319 1.000 37.81630  ? 514 SER B CA  1 
ATOM   1776 C C   . SER B 2 182 ? 28.91108 -29.11133 -20.83880 1.000 38.52099  ? 514 SER B C   1 
ATOM   1777 O O   . SER B 2 182 ? 30.09149 -29.15637 -21.19638 1.000 36.76177  ? 514 SER B O   1 
ATOM   1778 C CB  . SER B 2 182 ? 28.71268 -27.57871 -18.87054 1.000 39.18073  ? 514 SER B CB  1 
ATOM   1779 O OG  . SER B 2 182 ? 28.28518 -27.45266 -17.52690 1.000 48.58834  ? 514 SER B OG  1 
ATOM   1780 N N   . PHE B 2 183 ? 27.89161 -29.14990 -21.68857 1.000 40.30547  ? 515 PHE B N   1 
ATOM   1781 C CA  . PHE B 2 183 ? 28.05783 -29.25722 -23.13586 1.000 38.70773  ? 515 PHE B CA  1 
ATOM   1782 C C   . PHE B 2 183 ? 27.60523 -27.94063 -23.75505 1.000 37.44111  ? 515 PHE B C   1 
ATOM   1783 O O   . PHE B 2 183 ? 26.40624 -27.70933 -23.92997 1.000 40.99090  ? 515 PHE B O   1 
ATOM   1784 C CB  . PHE B 2 183 ? 27.25952 -30.43399 -23.68547 1.000 37.49472  ? 515 PHE B CB  1 
ATOM   1785 C CG  . PHE B 2 183 ? 27.69178 -31.76526 -23.14667 1.000 35.60068  ? 515 PHE B CG  1 
ATOM   1786 C CD1 . PHE B 2 183 ? 29.01813 -32.00206 -22.83248 1.000 39.37054  ? 515 PHE B CD1 1 
ATOM   1787 C CD2 . PHE B 2 183 ? 26.77054 -32.77811 -22.95090 1.000 35.83794  ? 515 PHE B CD2 1 
ATOM   1788 C CE1 . PHE B 2 183 ? 29.42075 -33.22547 -22.33715 1.000 38.05550  ? 515 PHE B CE1 1 
ATOM   1789 C CE2 . PHE B 2 183 ? 27.16496 -34.00325 -22.45236 1.000 43.36311  ? 515 PHE B CE2 1 
ATOM   1790 C CZ  . PHE B 2 183 ? 28.49356 -34.22755 -22.14518 1.000 42.05694  ? 515 PHE B CZ  1 
ATOM   1791 N N   . GLU B 2 184 ? 28.56299 -27.07637 -24.07933 1.000 35.34091  ? 516 GLU B N   1 
ATOM   1792 C CA  . GLU B 2 184 ? 28.24052 -25.78546 -24.67018 1.000 40.15209  ? 516 GLU B CA  1 
ATOM   1793 C C   . GLU B 2 184 ? 28.02645 -25.93069 -26.17200 1.000 46.99940  ? 516 GLU B C   1 
ATOM   1794 O O   . GLU B 2 184 ? 28.80373 -26.59946 -26.86043 1.000 44.89025  ? 516 GLU B O   1 
ATOM   1795 C CB  . GLU B 2 184 ? 29.34640 -24.77028 -24.38823 1.000 47.34349  ? 516 GLU B CB  1 
ATOM   1796 C CG  . GLU B 2 184 ? 29.26396 -24.12657 -23.01420 1.000 51.18264  ? 516 GLU B CG  1 
ATOM   1797 C CD  . GLU B 2 184 ? 30.28983 -23.02574 -22.82749 1.000 58.80280  ? 516 GLU B CD  1 
ATOM   1798 O OE1 . GLU B 2 184 ? 31.26673 -22.98134 -23.60616 1.000 60.43332  ? 516 GLU B OE1 1 
ATOM   1799 O OE2 . GLU B 2 184 ? 30.11675 -22.20129 -21.90594 1.000 65.86990  ? 516 GLU B OE2 1 
ATOM   1800 N N   . LEU B 2 185 ? 26.96868 -25.30121 -26.67541 1.000 44.44760  ? 517 LEU B N   1 
ATOM   1801 C CA  . LEU B 2 185 ? 26.60522 -25.34357 -28.08893 1.000 45.59051  ? 517 LEU B CA  1 
ATOM   1802 C C   . LEU B 2 185 ? 26.52175 -23.90471 -28.58793 1.000 47.96543  ? 517 LEU B C   1 
ATOM   1803 O O   . LEU B 2 185 ? 25.43423 -23.35738 -28.78169 1.000 49.87353  ? 517 LEU B O   1 
ATOM   1804 C CB  . LEU B 2 185 ? 25.29053 -26.09645 -28.28463 1.000 50.14980  ? 517 LEU B CB  1 
ATOM   1805 C CG  . LEU B 2 185 ? 24.89917 -26.43314 -29.72303 1.000 59.71870  ? 517 LEU B CG  1 
ATOM   1806 C CD1 . LEU B 2 185 ? 25.91258 -27.38199 -30.34534 1.000 54.67115  ? 517 LEU B CD1 1 
ATOM   1807 C CD2 . LEU B 2 185 ? 23.49914 -27.02447 -29.76934 1.000 64.57169  ? 517 LEU B CD2 1 
ATOM   1808 N N   . LEU B 2 186 ? 27.68251 -23.29096 -28.78865 1.000 49.85580  ? 518 LEU B N   1 
ATOM   1809 C CA  . LEU B 2 186 ? 27.75710 -21.92198 -29.27171 1.000 54.71583  ? 518 LEU B CA  1 
ATOM   1810 C C   . LEU B 2 186 ? 27.83725 -21.89538 -30.79767 1.000 54.64981  ? 518 LEU B C   1 
ATOM   1811 O O   . LEU B 2 186 ? 28.03717 -22.91846 -31.45580 1.000 62.34602  ? 518 LEU B O   1 
ATOM   1812 C CB  . LEU B 2 186 ? 28.96156 -21.20783 -28.65892 1.000 52.86530  ? 518 LEU B CB  1 
ATOM   1813 C CG  . LEU B 2 186 ? 29.09827 -21.29895 -27.13737 1.000 57.56700  ? 518 LEU B CG  1 
ATOM   1814 C CD1 . LEU B 2 186 ? 30.32439 -20.53296 -26.66291 1.000 53.53157  ? 518 LEU B CD1 1 
ATOM   1815 C CD2 . LEU B 2 186 ? 27.84133 -20.79252 -26.44595 1.000 53.63528  ? 518 LEU B CD2 1 
ATOM   1816 N N   . HIS B 2 187 ? 27.67399 -20.69733 -31.36270 1.000 55.42142  ? 519 HIS B N   1 
ATOM   1817 C CA  . HIS B 2 187 ? 27.78238 -20.49490 -32.80960 1.000 53.01373  ? 519 HIS B CA  1 
ATOM   1818 C C   . HIS B 2 187 ? 29.26346 -20.49241 -33.17567 1.000 51.14897  ? 519 HIS B C   1 
ATOM   1819 O O   . HIS B 2 187 ? 29.88427 -19.45329 -33.41372 1.000 50.87032  ? 519 HIS B O   1 
ATOM   1820 C CB  . HIS B 2 187 ? 27.09338 -19.20207 -33.22786 1.000 43.57083  ? 519 HIS B CB  1 
ATOM   1821 C CG  . HIS B 2 187 ? 25.62346 -19.18439 -32.94682 1.000 50.47827  ? 519 HIS B CG  1 
ATOM   1822 N ND1 . HIS B 2 187 ? 24.85668 -20.32937 -32.92387 1.000 58.41439  ? 519 HIS B ND1 1 
ATOM   1823 C CD2 . HIS B 2 187 ? 24.78036 -18.16254 -32.66858 1.000 50.36274  ? 519 HIS B CD2 1 
ATOM   1824 C CE1 . HIS B 2 187 ? 23.60372 -20.01298 -32.64955 1.000 60.78307  ? 519 HIS B CE1 1 
ATOM   1825 N NE2 . HIS B 2 187 ? 23.53042 -18.70398 -32.49001 1.000 56.87425  ? 519 HIS B NE2 1 
ATOM   1826 N N   . ALA B 2 188 ? 29.83555 -21.68913 -33.22007 1.000 46.87476  ? 520 ALA B N   1 
ATOM   1827 C CA  . ALA B 2 188 ? 31.27112 -21.86487 -33.37864 1.000 49.74003  ? 520 ALA B CA  1 
ATOM   1828 C C   . ALA B 2 188 ? 31.53391 -23.31857 -33.76712 1.000 48.50446  ? 520 ALA B C   1 
ATOM   1829 O O   . ALA B 2 188 ? 30.66803 -24.17518 -33.57023 1.000 49.86359  ? 520 ALA B O   1 
ATOM   1830 C CB  . ALA B 2 188 ? 32.02289 -21.50579 -32.08486 1.000 47.10321  ? 520 ALA B CB  1 
ATOM   1831 N N   . PRO B 2 189 ? 32.70810 -23.61341 -34.32729 1.000 52.59141  ? 521 PRO B N   1 
ATOM   1832 C CA  . PRO B 2 189 ? 33.02733 -25.00890 -34.65122 1.000 55.33562  ? 521 PRO B CA  1 
ATOM   1833 C C   . PRO B 2 189 ? 33.15661 -25.85169 -33.39388 1.000 54.54897  ? 521 PRO B C   1 
ATOM   1834 O O   . PRO B 2 189 ? 33.71037 -25.41475 -32.38251 1.000 59.08106  ? 521 PRO B O   1 
ATOM   1835 C CB  . PRO B 2 189 ? 34.36386 -24.90533 -35.39688 1.000 53.44022  ? 521 PRO B CB  1 
ATOM   1836 C CG  . PRO B 2 189 ? 34.94831 -23.61290 -34.94257 1.000 50.17698  ? 521 PRO B CG  1 
ATOM   1837 C CD  . PRO B 2 189 ? 33.77303 -22.69827 -34.77119 1.000 53.45017  ? 521 PRO B CD  1 
ATOM   1838 N N   . ALA B 2 190 ? 32.63336 -27.07227 -33.46767 1.000 55.99621  ? 522 ALA B N   1 
ATOM   1839 C CA  . ALA B 2 190 ? 32.69333 -27.98416 -32.33532 1.000 46.60787  ? 522 ALA B CA  1 
ATOM   1840 C C   . ALA B 2 190 ? 34.11425 -28.49833 -32.14878 1.000 49.71433  ? 522 ALA B C   1 
ATOM   1841 O O   . ALA B 2 190 ? 34.74357 -28.97524 -33.09704 1.000 51.00661  ? 522 ALA B O   1 
ATOM   1842 C CB  . ALA B 2 190 ? 31.72872 -29.14728 -32.54429 1.000 49.10598  ? 522 ALA B CB  1 
ATOM   1843 N N   . THR B 2 191 ? 34.62142 -28.40082 -30.91991 1.000 55.77956  ? 523 THR B N   1 
ATOM   1844 C CA  . THR B 2 191 ? 35.97960 -28.82287 -30.61400 1.000 56.61787  ? 523 THR B CA  1 
ATOM   1845 C C   . THR B 2 191 ? 36.04748 -30.10549 -29.79643 1.000 49.28834  ? 523 THR B C   1 
ATOM   1846 O O   . THR B 2 191 ? 37.13773 -30.67065 -29.65555 1.000 56.50764  ? 523 THR B O   1 
ATOM   1847 C CB  . THR B 2 191 ? 36.72899 -27.70743 -29.86742 1.000 59.13037  ? 523 THR B CB  1 
ATOM   1848 O OG1 . THR B 2 191 ? 38.14077 -27.90776 -29.99762 1.000 66.81994  ? 523 THR B OG1 1 
ATOM   1849 C CG2 . THR B 2 191 ? 36.36379 -27.70948 -28.39203 1.000 46.64790  ? 523 THR B CG2 1 
ATOM   1850 N N   . VAL B 2 192 ? 34.92671 -30.57813 -29.25640 1.000 42.18170  ? 524 VAL B N   1 
ATOM   1851 C CA  . VAL B 2 192 ? 34.88057 -31.81629 -28.48725 1.000 44.09492  ? 524 VAL B CA  1 
ATOM   1852 C C   . VAL B 2 192 ? 33.82916 -32.71412 -29.11734 1.000 43.50749  ? 524 VAL B C   1 
ATOM   1853 O O   . VAL B 2 192 ? 32.65223 -32.34170 -29.18292 1.000 44.49935  ? 524 VAL B O   1 
ATOM   1854 C CB  . VAL B 2 192 ? 34.55985 -31.57130 -27.00249 1.000 48.88786  ? 524 VAL B CB  1 
ATOM   1855 C CG1 . VAL B 2 192 ? 34.44642 -32.89687 -26.26173 1.000 47.76847  ? 524 VAL B CG1 1 
ATOM   1856 C CG2 . VAL B 2 192 ? 35.62029 -30.69276 -26.36643 1.000 46.85998  ? 524 VAL B CG2 1 
ATOM   1857 N N   . CYS B 2 193 ? 34.24840 -33.89007 -29.57518 1.000 42.86833  ? 525 CYS B N   1 
ATOM   1858 C CA  . CYS B 2 193 ? 33.36578 -34.83837 -30.23501 1.000 50.94940  ? 525 CYS B CA  1 
ATOM   1859 C C   . CYS B 2 193 ? 33.42592 -36.18922 -29.53960 1.000 44.28634  ? 525 CYS B C   1 
ATOM   1860 O O   . CYS B 2 193 ? 34.47083 -36.59730 -29.02697 1.000 50.35572  ? 525 CYS B O   1 
ATOM   1861 C CB  . CYS B 2 193 ? 33.73651 -35.02505 -31.71141 1.000 52.31997  ? 525 CYS B CB  1 
ATOM   1862 S SG  . CYS B 2 193 ? 33.32122 -33.64950 -32.78777 1.000 55.60502  ? 525 CYS B SG  1 
ATOM   1863 N N   . GLY B 2 194 ? 32.29339 -36.88529 -29.54107 1.000 47.85536  ? 526 GLY B N   1 
ATOM   1864 C CA  . GLY B 2 194 ? 32.26474 -38.24490 -29.05003 1.000 55.68965  ? 526 GLY B CA  1 
ATOM   1865 C C   . GLY B 2 194 ? 33.06776 -39.18314 -29.92977 1.000 54.23193  ? 526 GLY B C   1 
ATOM   1866 O O   . GLY B 2 194 ? 33.42189 -38.87295 -31.06919 1.000 56.35353  ? 526 GLY B O   1 
ATOM   1867 N N   . SER B 2 195 ? 33.35544 -40.36584 -29.38205 1.000 59.21399  ? 527 SER B N   1 
ATOM   1868 C CA  . SER B 2 195 ? 34.19958 -41.32622 -30.08336 1.000 60.28451  ? 527 SER B CA  1 
ATOM   1869 C C   . SER B 2 195 ? 33.55633 -41.85393 -31.35968 1.000 58.21544  ? 527 SER B C   1 
ATOM   1870 O O   . SER B 2 195 ? 34.27376 -42.32684 -32.24589 1.000 57.39974  ? 527 SER B O   1 
ATOM   1871 C CB  . SER B 2 195 ? 34.54607 -42.49449 -29.15951 1.000 55.70239  ? 527 SER B CB  1 
ATOM   1872 O OG  . SER B 2 195 ? 33.38594 -43.23156 -28.81967 1.000 59.79108  ? 527 SER B OG  1 
ATOM   1873 N N   . ASN B 2 196 ? 32.22986 -41.78108 -31.47979 1.000 60.16190  ? 528 ASN B N   1 
ATOM   1874 C CA  . ASN B 2 196 ? 31.52082 -42.31886 -32.63426 1.000 59.63743  ? 528 ASN B CA  1 
ATOM   1875 C C   . ASN B 2 196 ? 30.99106 -41.22318 -33.55569 1.000 66.96411  ? 528 ASN B C   1 
ATOM   1876 O O   . ASN B 2 196 ? 30.05761 -41.46339 -34.32768 1.000 63.32836  ? 528 ASN B O   1 
ATOM   1877 C CB  . ASN B 2 196 ? 30.37797 -43.22696 -32.17615 1.000 60.23989  ? 528 ASN B CB  1 
ATOM   1878 C CG  . ASN B 2 196 ? 29.97947 -44.24354 -33.23246 1.000 68.68771  ? 528 ASN B CG  1 
ATOM   1879 O OD1 . ASN B 2 196 ? 30.80973 -44.68915 -34.02613 1.000 77.69804  ? 528 ASN B OD1 1 
ATOM   1880 N ND2 . ASN B 2 196 ? 28.70333 -44.61199 -33.24914 1.000 62.56643  ? 528 ASN B ND2 1 
ATOM   1881 N N   . SER B 2 197 ? 31.56408 -40.02627 -33.49298 1.000 65.72250  ? 529 SER B N   1 
ATOM   1882 C CA  . SER B 2 197 ? 31.13263 -38.94805 -34.36721 1.000 63.53984  ? 529 SER B CA  1 
ATOM   1883 C C   . SER B 2 197 ? 31.79598 -39.07749 -35.73307 1.000 73.98249  ? 529 SER B C   1 
ATOM   1884 O O   . SER B 2 197 ? 32.88638 -39.63798 -35.86871 1.000 70.84173  ? 529 SER B O   1 
ATOM   1885 C CB  . SER B 2 197 ? 31.46116 -37.58952 -33.74950 1.000 58.00901  ? 529 SER B CB  1 
ATOM   1886 O OG  . SER B 2 197 ? 31.01468 -36.52745 -34.57375 1.000 61.97420  ? 529 SER B OG  1 
ATOM   1887 N N   . GLU B 2 198 ? 31.12671 -38.54424 -36.75388 1.000 75.84634  ? 530 GLU B N   1 
ATOM   1888 C CA  . GLU B 2 198 ? 31.62300 -38.64833 -38.12151 1.000 75.73564  ? 530 GLU B CA  1 
ATOM   1889 C C   . GLU B 2 198 ? 32.68092 -37.58570 -38.39920 1.000 78.84381  ? 530 GLU B C   1 
ATOM   1890 O O   . GLU B 2 198 ? 32.76660 -37.05951 -39.51427 1.000 81.70257  ? 530 GLU B O   1 
ATOM   1891 C CB  . GLU B 2 198 ? 30.46681 -38.54310 -39.12038 1.000 75.38339  ? 530 GLU B CB  1 
ATOM   1892 C CG  . GLU B 2 198 ? 29.66817 -37.24921 -39.04984 1.000 78.03779  ? 530 GLU B CG  1 
ATOM   1893 C CD  . GLU B 2 198 ? 28.53227 -37.30659 -38.04879 1.000 84.30891  ? 530 GLU B CD  1 
ATOM   1894 O OE1 . GLU B 2 198 ? 28.73184 -37.85825 -36.94455 1.000 83.67207  ? 530 GLU B OE1 1 
ATOM   1895 O OE2 . GLU B 2 198 ? 27.43579 -36.80063 -38.37293 1.000 83.56566  ? 530 GLU B OE2 1 
ATOM   1896 N N   . ASN B 2 199 ? 33.50538 -37.28817 -37.39004 1.000 75.80580  ? 531 ASN B N   1 
ATOM   1897 C CA  . ASN B 2 199 ? 34.50369 -36.21968 -37.45155 1.000 71.90236  ? 531 ASN B CA  1 
ATOM   1898 C C   . ASN B 2 199 ? 33.86495 -34.87940 -37.80353 1.000 79.25167  ? 531 ASN B C   1 
ATOM   1899 O O   . ASN B 2 199 ? 34.48612 -34.03273 -38.44915 1.000 85.46888  ? 531 ASN B O   1 
ATOM   1900 C CB  . ASN B 2 199 ? 35.63141 -36.55809 -38.43367 1.000 72.85210  ? 531 ASN B CB  1 
ATOM   1901 C CG  . ASN B 2 199 ? 36.47507 -37.73232 -37.97027 1.000 76.00310  ? 531 ASN B CG  1 
ATOM   1902 O OD1 . ASN B 2 199 ? 36.07156 -38.49261 -37.08872 1.000 73.87888  ? 531 ASN B OD1 1 
ATOM   1903 N ND2 . ASN B 2 199 ? 37.65333 -37.88522 -38.56273 1.000 75.07308  ? 531 ASN B ND2 1 
ATOM   1904 N N   . LEU B 2 200 ? 32.62378 -34.67278 -37.37254 1.000 75.22259  ? 532 LEU B N   1 
ATOM   1905 C CA  . LEU B 2 200 ? 31.90699 -33.43814 -37.66735 1.000 75.16029  ? 532 LEU B CA  1 
ATOM   1906 C C   . LEU B 2 200 ? 31.98288 -32.46089 -36.49869 1.000 71.30809  ? 532 LEU B C   1 
ATOM   1907 O O   . LEU B 2 200 ? 32.00639 -31.24492 -36.69449 1.000 70.86817  ? 532 LEU B O   1 
ATOM   1908 C CB  . LEU B 2 200 ? 30.44725 -33.73825 -38.00953 1.000 73.94322  ? 532 LEU B CB  1 
ATOM   1909 N N   . ASP C 1 1   ? 57.39496 1.35513   -19.92045 1.000 67.33175  ? 1   ASP C N   1 
ATOM   1910 C CA  . ASP C 1 1   ? 57.73720 1.38568   -18.50354 1.000 69.91378  ? 1   ASP C CA  1 
ATOM   1911 C C   . ASP C 1 1   ? 56.51890 1.73120   -17.65717 1.000 64.46096  ? 1   ASP C C   1 
ATOM   1912 O O   . ASP C 1 1   ? 55.40603 1.82872   -18.17361 1.000 63.10435  ? 1   ASP C O   1 
ATOM   1913 C CB  . ASP C 1 1   ? 58.85841 2.39182   -18.24240 1.000 74.73496  ? 1   ASP C CB  1 
ATOM   1914 C CG  . ASP C 1 1   ? 58.47821 3.80394   -18.64303 1.000 75.67854  ? 1   ASP C CG  1 
ATOM   1915 O OD1 . ASP C 1 1   ? 57.90379 3.98082   -19.73932 1.000 73.33883  ? 1   ASP C OD1 1 
ATOM   1916 O OD2 . ASP C 1 1   ? 58.74893 4.73650   -17.85730 1.000 76.54155  ? 1   ASP C OD2 1 
ATOM   1917 N N   . LYS C 1 2   ? 56.74326 1.92319   -16.35333 1.000 70.15521  ? 2   LYS C N   1 
ATOM   1918 C CA  . LYS C 1 2   ? 55.64113 2.23210   -15.44600 1.000 67.76555  ? 2   LYS C CA  1 
ATOM   1919 C C   . LYS C 1 2   ? 54.95614 3.53882   -15.82663 1.000 69.32461  ? 2   LYS C C   1 
ATOM   1920 O O   . LYS C 1 2   ? 53.73317 3.66855   -15.69087 1.000 67.05451  ? 2   LYS C O   1 
ATOM   1921 C CB  . LYS C 1 2   ? 56.14469 2.29222   -14.00271 1.000 65.12487  ? 2   LYS C CB  1 
ATOM   1922 C CG  . LYS C 1 2   ? 55.10329 2.79906   -13.01596 1.000 69.44664  ? 2   LYS C CG  1 
ATOM   1923 C CD  . LYS C 1 2   ? 55.49122 2.52471   -11.57569 1.000 75.07574  ? 2   LYS C CD  1 
ATOM   1924 C CE  . LYS C 1 2   ? 54.35769 2.90291   -10.63475 1.000 71.82155  ? 2   LYS C CE  1 
ATOM   1925 N NZ  . LYS C 1 2   ? 54.04796 4.35831   -10.68828 1.000 68.19935  ? 2   LYS C NZ  1 
ATOM   1926 N N   . GLU C 1 3   ? 55.72738 4.51725   -16.30824 1.000 73.07834  ? 3   GLU C N   1 
ATOM   1927 C CA  . GLU C 1 3   ? 55.14478 5.79305   -16.71270 1.000 66.51513  ? 3   GLU C CA  1 
ATOM   1928 C C   . GLU C 1 3   ? 54.09511 5.59681   -17.79722 1.000 59.63965  ? 3   GLU C C   1 
ATOM   1929 O O   . GLU C 1 3   ? 52.97237 6.10390   -17.69082 1.000 58.35424  ? 3   GLU C O   1 
ATOM   1930 C CB  . GLU C 1 3   ? 56.24078 6.74339   -17.19382 1.000 64.70419  ? 3   GLU C CB  1 
ATOM   1931 C CG  . GLU C 1 3   ? 57.13490 7.27103   -16.08852 1.000 70.08527  ? 3   GLU C CG  1 
ATOM   1932 C CD  . GLU C 1 3   ? 58.02840 8.40047   -16.55803 1.000 75.05326  ? 3   GLU C CD  1 
ATOM   1933 O OE1 . GLU C 1 3   ? 58.31743 8.46633   -17.77301 1.000 77.88003  ? 3   GLU C OE1 1 
ATOM   1934 O OE2 . GLU C 1 3   ? 58.43377 9.22670   -15.71299 1.000 74.89990  ? 3   GLU C OE2 1 
ATOM   1935 N N   . TRP C 1 4   ? 54.44183 4.85240   -18.84904 1.000 62.69584  ? 4   TRP C N   1 
ATOM   1936 C CA  . TRP C 1 4   ? 53.49383 4.63250   -19.93523 1.000 65.95832  ? 4   TRP C CA  1 
ATOM   1937 C C   . TRP C 1 4   ? 52.35225 3.72579   -19.49289 1.000 59.31607  ? 4   TRP C C   1 
ATOM   1938 O O   . TRP C 1 4   ? 51.20081 3.92593   -19.89772 1.000 58.70278  ? 4   TRP C O   1 
ATOM   1939 C CB  . TRP C 1 4   ? 54.21227 4.04481   -21.15083 1.000 71.36174  ? 4   TRP C CB  1 
ATOM   1940 C CG  . TRP C 1 4   ? 53.47414 4.26305   -22.43566 1.000 74.16867  ? 4   TRP C CG  1 
ATOM   1941 C CD1 . TRP C 1 4   ? 52.56002 3.42849   -23.00951 1.000 78.13042  ? 4   TRP C CD1 1 
ATOM   1942 C CD2 . TRP C 1 4   ? 53.58262 5.39818   -23.30460 1.000 79.43494  ? 4   TRP C CD2 1 
ATOM   1943 N NE1 . TRP C 1 4   ? 52.09404 3.97236   -24.18285 1.000 79.65358  ? 4   TRP C NE1 1 
ATOM   1944 C CE2 . TRP C 1 4   ? 52.70673 5.18102   -24.38681 1.000 80.81937  ? 4   TRP C CE2 1 
ATOM   1945 C CE3 . TRP C 1 4   ? 54.33654 6.57619   -23.27279 1.000 77.05075  ? 4   TRP C CE3 1 
ATOM   1946 C CZ2 . TRP C 1 4   ? 52.56316 6.09882   -25.42715 1.000 82.52457  ? 4   TRP C CZ2 1 
ATOM   1947 C CZ3 . TRP C 1 4   ? 54.19305 7.48557   -24.30746 1.000 80.52594  ? 4   TRP C CZ3 1 
ATOM   1948 C CH2 . TRP C 1 4   ? 53.31406 7.24100   -25.36963 1.000 81.73749  ? 4   TRP C CH2 1 
ATOM   1949 N N   . ILE C 1 5   ? 52.65036 2.72802   -18.65694 1.000 58.79465  ? 5   ILE C N   1 
ATOM   1950 C CA  . ILE C 1 5   ? 51.60773 1.82683   -18.17283 1.000 56.60161  ? 5   ILE C CA  1 
ATOM   1951 C C   . ILE C 1 5   ? 50.59542 2.58819   -17.32640 1.000 59.69886  ? 5   ILE C C   1 
ATOM   1952 O O   . ILE C 1 5   ? 49.38111 2.39802   -17.46353 1.000 57.41522  ? 5   ILE C O   1 
ATOM   1953 C CB  . ILE C 1 5   ? 52.23384 0.65495   -17.39366 1.000 58.41691  ? 5   ILE C CB  1 
ATOM   1954 C CG1 . ILE C 1 5   ? 53.03195 -0.24687  -18.33629 1.000 61.98152  ? 5   ILE C CG1 1 
ATOM   1955 C CG2 . ILE C 1 5   ? 51.16129 -0.14669  -16.67249 1.000 58.41620  ? 5   ILE C CG2 1 
ATOM   1956 C CD1 . ILE C 1 5   ? 53.87751 -1.27852  -17.62283 1.000 61.83013  ? 5   ILE C CD1 1 
ATOM   1957 N N   . LEU C 1 6   ? 51.07566 3.47375   -16.45026 1.000 58.48944  ? 6   LEU C N   1 
ATOM   1958 C CA  . LEU C 1 6   ? 50.16848 4.21332   -15.57847 1.000 55.70433  ? 6   LEU C CA  1 
ATOM   1959 C C   . LEU C 1 6   ? 49.25274 5.13030   -16.37940 1.000 50.88629  ? 6   LEU C C   1 
ATOM   1960 O O   . LEU C 1 6   ? 48.06520 5.26320   -16.06234 1.000 54.15394  ? 6   LEU C O   1 
ATOM   1961 C CB  . LEU C 1 6   ? 50.96568 5.01513   -14.54998 1.000 58.49277  ? 6   LEU C CB  1 
ATOM   1962 C CG  . LEU C 1 6   ? 50.15548 5.72671   -13.46440 1.000 60.41124  ? 6   LEU C CG  1 
ATOM   1963 C CD1 . LEU C 1 6   ? 49.25563 4.74215   -12.73290 1.000 48.84927  ? 6   LEU C CD1 1 
ATOM   1964 C CD2 . LEU C 1 6   ? 51.08085 6.43214   -12.48802 1.000 54.12011  ? 6   LEU C CD2 1 
ATOM   1965 N N   . GLN C 1 7   ? 49.78374 5.76754   -17.42499 1.000 48.65966  ? 7   GLN C N   1 
ATOM   1966 C CA  . GLN C 1 7   ? 48.96247 6.66186   -18.23518 1.000 53.80759  ? 7   GLN C CA  1 
ATOM   1967 C C   . GLN C 1 7   ? 47.84084 5.90332   -18.93426 1.000 51.78818  ? 7   GLN C C   1 
ATOM   1968 O O   . GLN C 1 7   ? 46.70452 6.38673   -19.00458 1.000 50.43400  ? 7   GLN C O   1 
ATOM   1969 C CB  . GLN C 1 7   ? 49.83051 7.39201   -19.25896 1.000 50.84619  ? 7   GLN C CB  1 
ATOM   1970 C CG  . GLN C 1 7   ? 49.07457 8.42389   -20.07508 1.000 49.07305  ? 7   GLN C CG  1 
ATOM   1971 C CD  . GLN C 1 7   ? 48.63142 9.60844   -19.24210 1.000 47.58443  ? 7   GLN C CD  1 
ATOM   1972 O OE1 . GLN C 1 7   ? 49.36167 10.07082  -18.36911 1.000 50.34792  ? 7   GLN C OE1 1 
ATOM   1973 N NE2 . GLN C 1 7   ? 47.42798 10.10307  -19.50464 1.000 48.01585  ? 7   GLN C NE2 1 
ATOM   1974 N N   . LYS C 1 8   ? 48.14062 4.70937   -19.45260 1.000 49.72437  ? 8   LYS C N   1 
ATOM   1975 C CA  . LYS C 1 8   ? 47.12726 3.92910   -20.15571 1.000 49.02652  ? 8   LYS C CA  1 
ATOM   1976 C C   . LYS C 1 8   ? 45.99054 3.52685   -19.22556 1.000 46.68360  ? 8   LYS C C   1 
ATOM   1977 O O   . LYS C 1 8   ? 44.81635 3.58455   -19.60768 1.000 41.30610  ? 8   LYS C O   1 
ATOM   1978 C CB  . LYS C 1 8   ? 47.76454 2.69203   -20.78880 1.000 56.81991  ? 8   LYS C CB  1 
ATOM   1979 C CG  . LYS C 1 8   ? 48.73479 2.99283   -21.92340 1.000 56.38082  ? 8   LYS C CG  1 
ATOM   1980 C CD  . LYS C 1 8   ? 48.01648 3.56692   -23.13839 1.000 67.07463  ? 8   LYS C CD  1 
ATOM   1981 C CE  . LYS C 1 8   ? 48.36040 5.03446   -23.35495 1.000 67.03358  ? 8   LYS C CE  1 
ATOM   1982 N NZ  . LYS C 1 8   ? 47.66912 5.59314   -24.54851 1.000 69.80851  ? 8   LYS C NZ  1 
ATOM   1983 N N   . ILE C 1 9   ? 46.31777 3.11943   -17.99734 1.000 50.70740  ? 9   ILE C N   1 
ATOM   1984 C CA  . ILE C 1 9   ? 45.27770 2.71926   -17.05597 1.000 45.30784  ? 9   ILE C CA  1 
ATOM   1985 C C   . ILE C 1 9   ? 44.46413 3.92506   -16.60579 1.000 43.00250  ? 9   ILE C C   1 
ATOM   1986 O O   . ILE C 1 9   ? 43.25691 3.81091   -16.36009 1.000 45.78237  ? 9   ILE C O   1 
ATOM   1987 C CB  . ILE C 1 9   ? 45.90015 1.98032   -15.85989 1.000 54.83766  ? 9   ILE C CB  1 
ATOM   1988 C CG1 . ILE C 1 9   ? 46.87876 0.91580   -16.34601 1.000 54.33061  ? 9   ILE C CG1 1 
ATOM   1989 C CG2 . ILE C 1 9   ? 44.82217 1.32719   -15.01823 1.000 62.94915  ? 9   ILE C CG2 1 
ATOM   1990 C CD1 . ILE C 1 9   ? 47.85188 0.48133   -15.28341 1.000 65.54910  ? 9   ILE C CD1 1 
ATOM   1991 N N   . TYR C 1 10  ? 45.09828 5.09411   -16.49062 1.000 44.92541  ? 10  TYR C N   1 
ATOM   1992 C CA  . TYR C 1 10  ? 44.35919 6.30184   -16.13659 1.000 46.27355  ? 10  TYR C CA  1 
ATOM   1993 C C   . TYR C 1 10  ? 43.32778 6.63929   -17.20500 1.000 46.71825  ? 10  TYR C C   1 
ATOM   1994 O O   . TYR C 1 10  ? 42.16039 6.90779   -16.89707 1.000 45.55372  ? 10  TYR C O   1 
ATOM   1995 C CB  . TYR C 1 10  ? 45.32238 7.47192   -15.93324 1.000 49.02742  ? 10  TYR C CB  1 
ATOM   1996 C CG  . TYR C 1 10  ? 44.65376 8.71859   -15.39345 1.000 53.02862  ? 10  TYR C CG  1 
ATOM   1997 C CD1 . TYR C 1 10  ? 44.37640 8.84561   -14.03746 1.000 51.84360  ? 10  TYR C CD1 1 
ATOM   1998 C CD2 . TYR C 1 10  ? 44.30405 9.76878   -16.23460 1.000 51.74352  ? 10  TYR C CD2 1 
ATOM   1999 C CE1 . TYR C 1 10  ? 43.76733 9.97697   -13.53435 1.000 48.32415  ? 10  TYR C CE1 1 
ATOM   2000 C CE2 . TYR C 1 10  ? 43.69276 10.90922  -15.73706 1.000 55.47894  ? 10  TYR C CE2 1 
ATOM   2001 C CZ  . TYR C 1 10  ? 43.42771 11.00533  -14.38409 1.000 50.41088  ? 10  TYR C CZ  1 
ATOM   2002 O OH  . TYR C 1 10  ? 42.82158 12.13015  -13.87266 1.000 49.21962  ? 10  TYR C OH  1 
ATOM   2003 N N   . GLU C 1 11  ? 43.74560 6.62544   -18.47423 1.000 46.15625  ? 11  GLU C N   1 
ATOM   2004 C CA  . GLU C 1 11  ? 42.82189 6.91278   -19.56716 1.000 44.12034  ? 11  GLU C CA  1 
ATOM   2005 C C   . GLU C 1 11  ? 41.71078 5.87382   -19.63941 1.000 40.18943  ? 11  GLU C C   1 
ATOM   2006 O O   . GLU C 1 11  ? 40.56590 6.20185   -19.97136 1.000 43.36293  ? 11  GLU C O   1 
ATOM   2007 C CB  . GLU C 1 11  ? 43.58571 6.98230   -20.88889 1.000 51.22932  ? 11  GLU C CB  1 
ATOM   2008 C CG  . GLU C 1 11  ? 44.66428 8.06075   -20.91910 1.000 53.55558  ? 11  GLU C CG  1 
ATOM   2009 C CD  . GLU C 1 11  ? 45.49598 8.02537   -22.18864 1.000 64.40605  ? 11  GLU C CD  1 
ATOM   2010 O OE1 . GLU C 1 11  ? 45.33957 7.07180   -22.98211 1.000 68.79344  ? 11  GLU C OE1 1 
ATOM   2011 O OE2 . GLU C 1 11  ? 46.30814 8.95185   -22.39272 1.000 61.63601  ? 11  GLU C OE2 1 
ATOM   2012 N N   . ILE C 1 12  ? 42.02767 4.61520   -19.32393 1.000 43.71023  ? 12  ILE C N   1 
ATOM   2013 C CA  . ILE C 1 12  ? 40.99708 3.58082   -19.26365 1.000 43.54854  ? 12  ILE C CA  1 
ATOM   2014 C C   . ILE C 1 12  ? 39.98633 3.89732   -18.16678 1.000 45.53393  ? 12  ILE C C   1 
ATOM   2015 O O   . ILE C 1 12  ? 38.77708 3.69599   -18.33770 1.000 41.75932  ? 12  ILE C O   1 
ATOM   2016 C CB  . ILE C 1 12  ? 41.64086 2.19579   -19.06179 1.000 45.10357  ? 12  ILE C CB  1 
ATOM   2017 C CG1 . ILE C 1 12  ? 42.36936 1.75707   -20.33067 1.000 44.51965  ? 12  ILE C CG1 1 
ATOM   2018 C CG2 . ILE C 1 12  ? 40.59730 1.15944   -18.65979 1.000 44.86864  ? 12  ILE C CG2 1 
ATOM   2019 C CD1 . ILE C 1 12  ? 43.07342 0.42616   -20.19738 1.000 45.79207  ? 12  ILE C CD1 1 
ATOM   2020 N N   . MET C 1 13  ? 40.46226 4.40221   -17.02528 1.000 45.36735  ? 13  MET C N   1 
ATOM   2021 C CA  . MET C 1 13  ? 39.55217 4.77688   -15.94658 1.000 43.39125  ? 13  MET C CA  1 
ATOM   2022 C C   . MET C 1 13  ? 38.66610 5.94610   -16.36003 1.000 45.00172  ? 13  MET C C   1 
ATOM   2023 O O   . MET C 1 13  ? 37.44399 5.91381   -16.16943 1.000 44.51815  ? 13  MET C O   1 
ATOM   2024 C CB  . MET C 1 13  ? 40.34339 5.12879   -14.68550 1.000 43.05107  ? 13  MET C CB  1 
ATOM   2025 C CG  . MET C 1 13  ? 39.47733 5.40710   -13.46585 1.000 39.88828  ? 13  MET C CG  1 
ATOM   2026 S SD  . MET C 1 13  ? 40.11884 6.74234   -12.43654 1.000 49.36885  ? 13  MET C SD  1 
ATOM   2027 C CE  . MET C 1 13  ? 41.86511 6.36451   -12.43204 1.000 48.09662  ? 13  MET C CE  1 
ATOM   2028 N N   . ARG C 1 14  ? 39.26906 6.99126   -16.92873 1.000 41.31171  ? 14  ARG C N   1 
ATOM   2029 C CA  . ARG C 1 14  ? 38.49853 8.16611   -17.32154 1.000 45.71756  ? 14  ARG C CA  1 
ATOM   2030 C C   . ARG C 1 14  ? 37.50182 7.83356   -18.42581 1.000 50.01112  ? 14  ARG C C   1 
ATOM   2031 O O   . ARG C 1 14  ? 36.35241 8.29083   -18.39278 1.000 50.66564  ? 14  ARG C O   1 
ATOM   2032 C CB  . ARG C 1 14  ? 39.44198 9.28189   -17.76899 1.000 50.92639  ? 14  ARG C CB  1 
ATOM   2033 C CG  . ARG C 1 14  ? 40.44681 9.71448   -16.71447 1.000 47.62260  ? 14  ARG C CG  1 
ATOM   2034 C CD  . ARG C 1 14  ? 39.75529 10.38751  -15.54344 1.000 56.33815  ? 14  ARG C CD  1 
ATOM   2035 N NE  . ARG C 1 14  ? 38.88102 11.46824  -15.98375 1.000 58.91319  ? 14  ARG C NE  1 
ATOM   2036 C CZ  . ARG C 1 14  ? 39.28610 12.70601  -16.23306 1.000 60.77690  ? 14  ARG C CZ  1 
ATOM   2037 N NH1 . ARG C 1 14  ? 40.55490 13.05873  -16.09924 1.000 57.20226  ? 14  ARG C NH1 1 
ATOM   2038 N NH2 . ARG C 1 14  ? 38.39614 13.61230  -16.62830 1.000 58.53178  ? 14  ARG C NH2 1 
ATOM   2039 N N   . ARG C 1 15  ? 37.92269 7.03554   -19.41142 1.000 45.40057  ? 15  ARG C N   1 
ATOM   2040 C CA  . ARG C 1 15  ? 37.03167 6.69101   -20.51490 1.000 44.96331  ? 15  ARG C CA  1 
ATOM   2041 C C   . ARG C 1 15  ? 35.83588 5.88027   -20.03253 1.000 47.53429  ? 15  ARG C C   1 
ATOM   2042 O O   . ARG C 1 15  ? 34.70756 6.09347   -20.49098 1.000 46.84243  ? 15  ARG C O   1 
ATOM   2043 C CB  . ARG C 1 15  ? 37.79854 5.92824   -21.59542 1.000 52.82148  ? 15  ARG C CB  1 
ATOM   2044 C CG  . ARG C 1 15  ? 38.30420 6.80623   -22.73244 1.000 59.13219  ? 15  ARG C CG  1 
ATOM   2045 C CD  . ARG C 1 15  ? 38.91894 5.97405   -23.84730 1.000 60.61401  ? 15  ARG C CD  1 
ATOM   2046 N NE  . ARG C 1 15  ? 39.00708 6.71796   -25.09884 1.000 66.97600  ? 15  ARG C NE  1 
ATOM   2047 C CZ  . ARG C 1 15  ? 40.02890 7.48963   -25.44517 1.000 73.64077  ? 15  ARG C CZ  1 
ATOM   2048 N NH1 . ARG C 1 15  ? 41.07851 7.64445   -24.65399 1.000 73.93339  ? 15  ARG C NH1 1 
ATOM   2049 N NH2 . ARG C 1 15  ? 39.99628 8.12350   -26.61418 1.000 73.26119  ? 15  ARG C NH2 1 
ATOM   2050 N N   . LEU C 1 16  ? 36.05965 4.94848   -19.10375 1.000 45.20344  ? 16  LEU C N   1 
ATOM   2051 C CA  . LEU C 1 16  ? 34.95201 4.15723   -18.57732 1.000 43.12139  ? 16  LEU C CA  1 
ATOM   2052 C C   . LEU C 1 16  ? 33.96324 5.02753   -17.81374 1.000 43.38076  ? 16  LEU C C   1 
ATOM   2053 O O   . LEU C 1 16  ? 32.74781 4.81180   -17.89183 1.000 43.82955  ? 16  LEU C O   1 
ATOM   2054 C CB  . LEU C 1 16  ? 35.48444 3.04046   -17.68095 1.000 42.88275  ? 16  LEU C CB  1 
ATOM   2055 C CG  . LEU C 1 16  ? 36.11133 1.84492   -18.39699 1.000 43.72606  ? 16  LEU C CG  1 
ATOM   2056 C CD1 . LEU C 1 16  ? 36.76648 0.91380   -17.39254 1.000 40.94168  ? 16  LEU C CD1 1 
ATOM   2057 C CD2 . LEU C 1 16  ? 35.05949 1.10638   -19.21297 1.000 36.00147  ? 16  LEU C CD2 1 
ATOM   2058 N N   . ASP C 1 17  ? 34.46576 6.01859   -17.07377 1.000 48.36634  ? 17  ASP C N   1 
ATOM   2059 C CA  . ASP C 1 17  ? 33.58586 6.86543   -16.27663 1.000 48.61373  ? 17  ASP C CA  1 
ATOM   2060 C C   . ASP C 1 17  ? 32.79901 7.82556   -17.15970 1.000 45.83808  ? 17  ASP C C   1 
ATOM   2061 O O   . ASP C 1 17  ? 31.58553 7.98583   -16.98469 1.000 48.40546  ? 17  ASP C O   1 
ATOM   2062 C CB  . ASP C 1 17  ? 34.40337 7.62830   -15.23178 1.000 49.92361  ? 17  ASP C CB  1 
ATOM   2063 C CG  . ASP C 1 17  ? 33.56125 8.10411   -14.06251 1.000 50.85916  ? 17  ASP C CG  1 
ATOM   2064 O OD1 . ASP C 1 17  ? 32.89007 7.26165   -13.42822 1.000 47.09939  ? 17  ASP C OD1 1 
ATOM   2065 O OD2 . ASP C 1 17  ? 33.58144 9.31781   -13.77035 1.000 60.16069  ? 17  ASP C OD2 1 
ATOM   2066 N N   . GLU C 1 18  ? 33.46875 8.46437   -18.12230 1.000 48.39670  ? 18  GLU C N   1 
ATOM   2067 C CA  . GLU C 1 18  ? 32.77856 9.37477   -19.02880 1.000 49.85397  ? 18  GLU C CA  1 
ATOM   2068 C C   . GLU C 1 18  ? 31.77694 8.65359   -19.92096 1.000 46.64284  ? 18  GLU C C   1 
ATOM   2069 O O   . GLU C 1 18  ? 30.87269 9.29834   -20.46097 1.000 46.31302  ? 18  GLU C O   1 
ATOM   2070 C CB  . GLU C 1 18  ? 33.79026 10.13524  -19.88745 1.000 47.28587  ? 18  GLU C CB  1 
ATOM   2071 C CG  . GLU C 1 18  ? 34.50475 9.27682   -20.91405 1.000 54.50007  ? 18  GLU C CG  1 
ATOM   2072 C CD  . GLU C 1 18  ? 35.63191 10.01550  -21.61308 1.000 62.78696  ? 18  GLU C CD  1 
ATOM   2073 O OE1 . GLU C 1 18  ? 36.29219 10.84995  -20.95776 1.000 66.49341  ? 18  GLU C OE1 1 
ATOM   2074 O OE2 . GLU C 1 18  ? 35.85377 9.76476   -22.81869 1.000 63.12532  ? 18  GLU C OE2 1 
ATOM   2075 N N   . GLU C 1 19  ? 31.91110 7.33871   -20.08328 1.000 43.28877  ? 19  GLU C N   1 
ATOM   2076 C CA  . GLU C 1 19  ? 30.95724 6.54393   -20.84281 1.000 50.08393  ? 19  GLU C CA  1 
ATOM   2077 C C   . GLU C 1 19  ? 29.89551 5.90270   -19.95835 1.000 49.93742  ? 19  GLU C C   1 
ATOM   2078 O O   . GLU C 1 19  ? 29.11859 5.07190   -20.44269 1.000 47.56506  ? 19  GLU C O   1 
ATOM   2079 C CB  . GLU C 1 19  ? 31.69162 5.47419   -21.65594 1.000 47.81486  ? 19  GLU C CB  1 
ATOM   2080 C CG  . GLU C 1 19  ? 32.51669 6.04609   -22.80496 1.000 40.64933  ? 19  GLU C CG  1 
ATOM   2081 C CD  . GLU C 1 19  ? 33.48967 5.04239   -23.39621 1.000 42.78329  ? 19  GLU C CD  1 
ATOM   2082 O OE1 . GLU C 1 19  ? 33.16064 3.83793   -23.44543 1.000 43.81552  ? 19  GLU C OE1 1 
ATOM   2083 O OE2 . GLU C 1 19  ? 34.59096 5.46212   -23.80774 1.000 45.97014  ? 19  GLU C OE2 1 
ATOM   2084 N N   . GLY C 1 20  ? 29.84681 6.26666   -18.67716 1.000 47.25510  ? 20  GLY C N   1 
ATOM   2085 C CA  . GLY C 1 20  ? 28.80276 5.79798   -17.79074 1.000 43.59812  ? 20  GLY C CA  1 
ATOM   2086 C C   . GLY C 1 20  ? 29.03353 4.44279   -17.16468 1.000 40.70731  ? 20  GLY C C   1 
ATOM   2087 O O   . GLY C 1 20  ? 28.10604 3.89850   -16.55447 1.000 43.26339  ? 20  GLY C O   1 
ATOM   2088 N N   . HIS C 1 21  ? 30.23072 3.87312   -17.30071 1.000 37.14967  ? 21  HIS C N   1 
ATOM   2089 C CA  . HIS C 1 21  ? 30.55914 2.59888   -16.66026 1.000 41.30357  ? 21  HIS C CA  1 
ATOM   2090 C C   . HIS C 1 21  ? 31.17008 2.87748   -15.28465 1.000 42.98763  ? 21  HIS C C   1 
ATOM   2091 O O   . HIS C 1 21  ? 32.36096 2.67988   -15.03417 1.000 41.38704  ? 21  HIS C O   1 
ATOM   2092 C CB  . HIS C 1 21  ? 31.49662 1.78332   -17.54198 1.000 36.46711  ? 21  HIS C CB  1 
ATOM   2093 C CG  . HIS C 1 21  ? 30.97279 1.53858   -18.92401 1.000 45.92049  ? 21  HIS C CG  1 
ATOM   2094 N ND1 . HIS C 1 21  ? 29.78855 0.87589   -19.16591 1.000 47.32144  ? 21  HIS C ND1 1 
ATOM   2095 C CD2 . HIS C 1 21  ? 31.47733 1.86195   -20.13889 1.000 38.21477  ? 21  HIS C CD2 1 
ATOM   2096 C CE1 . HIS C 1 21  ? 29.58448 0.80531   -20.46946 1.000 45.98945  ? 21  HIS C CE1 1 
ATOM   2097 N NE2 . HIS C 1 21  ? 30.59513 1.39468   -21.08228 1.000 42.00925  ? 21  HIS C NE2 1 
ATOM   2098 N N   . ALA C 1 22  ? 30.30722 3.34532   -14.37869 1.000 42.98470  ? 22  ALA C N   1 
ATOM   2099 C CA  . ALA C 1 22  ? 30.77404 3.84504   -13.08747 1.000 46.61824  ? 22  ALA C CA  1 
ATOM   2100 C C   . ALA C 1 22  ? 31.46337 2.75068   -12.28077 1.000 43.15611  ? 22  ALA C C   1 
ATOM   2101 O O   . ALA C 1 22  ? 32.56894 2.94811   -11.76386 1.000 44.88470  ? 22  ALA C O   1 
ATOM   2102 C CB  . ALA C 1 22  ? 29.60393 4.44067   -12.30394 1.000 44.08055  ? 22  ALA C CB  1 
ATOM   2103 N N   . GLU C 1 23  ? 30.82480 1.58468   -12.16433 1.000 43.97733  ? 23  GLU C N   1 
ATOM   2104 C CA  . GLU C 1 23  ? 31.42044 0.49477   -11.39934 1.000 42.89076  ? 23  GLU C CA  1 
ATOM   2105 C C   . GLU C 1 23  ? 32.73367 0.03916   -12.02147 1.000 43.46681  ? 23  GLU C C   1 
ATOM   2106 O O   . GLU C 1 23  ? 33.68883 -0.28713  -11.30710 1.000 44.39688  ? 23  GLU C O   1 
ATOM   2107 C CB  . GLU C 1 23  ? 30.43972 -0.67194  -11.29918 1.000 46.54458  ? 23  GLU C CB  1 
ATOM   2108 C CG  . GLU C 1 23  ? 30.88567 -1.77309  -10.35221 1.000 51.21473  ? 23  GLU C CG  1 
ATOM   2109 C CD  . GLU C 1 23  ? 29.98430 -2.98767  -10.41189 1.000 52.87351  ? 23  GLU C CD  1 
ATOM   2110 O OE1 . GLU C 1 23  ? 29.15298 -3.06553  -11.33938 1.000 68.36272  ? 23  GLU C OE1 1 
ATOM   2111 O OE2 . GLU C 1 23  ? 30.10773 -3.86614  -9.53574  1.000 53.20021  ? 23  GLU C OE2 1 
ATOM   2112 N N   . ALA C 1 24  ? 32.80201 0.01668   -13.35446 1.000 48.95306  ? 24  ALA C N   1 
ATOM   2113 C CA  . ALA C 1 24  ? 34.04085 -0.35926  -14.02597 1.000 43.75250  ? 24  ALA C CA  1 
ATOM   2114 C C   . ALA C 1 24  ? 35.13187 0.67716   -13.79131 1.000 41.64809  ? 24  ALA C C   1 
ATOM   2115 O O   . ALA C 1 24  ? 36.30429 0.32340   -13.62043 1.000 41.78491  ? 24  ALA C O   1 
ATOM   2116 C CB  . ALA C 1 24  ? 33.79001 -0.54730  -15.52252 1.000 44.69437  ? 24  ALA C CB  1 
ATOM   2117 N N   . SER C 1 25  ? 34.76529 1.96174   -13.78181 1.000 40.84876  ? 25  SER C N   1 
ATOM   2118 C CA  . SER C 1 25  ? 35.74532 3.01142   -13.52023 1.000 41.11629  ? 25  SER C CA  1 
ATOM   2119 C C   . SER C 1 25  ? 36.32509 2.89103   -12.11617 1.000 40.62654  ? 25  SER C C   1 
ATOM   2120 O O   . SER C 1 25  ? 37.53705 3.04541   -11.92052 1.000 37.26537  ? 25  SER C O   1 
ATOM   2121 C CB  . SER C 1 25  ? 35.10532 4.38534   -13.71748 1.000 43.11275  ? 25  SER C CB  1 
ATOM   2122 O OG  . SER C 1 25  ? 35.98578 5.41995   -13.31439 1.000 51.65130  ? 25  SER C OG  1 
ATOM   2123 N N   . MET C 1 26  ? 35.47489 2.61261   -11.12513 1.000 36.38007  ? 26  MET C N   1 
ATOM   2124 C CA  . MET C 1 26  ? 35.95569 2.51713   -9.75139  1.000 39.73195  ? 26  MET C CA  1 
ATOM   2125 C C   . MET C 1 26  ? 36.86768 1.31309   -9.55792  1.000 42.66122  ? 26  MET C C   1 
ATOM   2126 O O   . MET C 1 26  ? 37.81677 1.37768   -8.76757  1.000 40.31143  ? 26  MET C O   1 
ATOM   2127 C CB  . MET C 1 26  ? 34.77294 2.46158   -8.78540  1.000 38.79232  ? 26  MET C CB  1 
ATOM   2128 C CG  . MET C 1 26  ? 33.90992 3.71586   -8.80284  1.000 44.58544  ? 26  MET C CG  1 
ATOM   2129 S SD  . MET C 1 26  ? 32.65482 3.74365   -7.50854  1.000 60.71677  ? 26  MET C SD  1 
ATOM   2130 C CE  . MET C 1 26  ? 31.63235 2.35797   -7.99197  1.000 48.60384  ? 26  MET C CE  1 
ATOM   2131 N N   . ARG C 1 27  ? 36.60600 0.21492   -10.27184 1.000 44.52290  ? 27  ARG C N   1 
ATOM   2132 C CA  . ARG C 1 27  ? 37.49276 -0.94053  -10.19188 1.000 35.73687  ? 27  ARG C CA  1 
ATOM   2133 C C   . ARG C 1 27  ? 38.86103 -0.62049  -10.77664 1.000 38.69825  ? 27  ARG C C   1 
ATOM   2134 O O   . ARG C 1 27  ? 39.88644 -1.07997  -10.26137 1.000 39.25237  ? 27  ARG C O   1 
ATOM   2135 C CB  . ARG C 1 27  ? 36.86804 -2.13492  -10.90885 1.000 37.93869  ? 27  ARG C CB  1 
ATOM   2136 C CG  . ARG C 1 27  ? 35.63177 -2.69913  -10.23241 1.000 41.51299  ? 27  ARG C CG  1 
ATOM   2137 C CD  . ARG C 1 27  ? 35.04735 -3.82788  -11.06065 1.000 45.85675  ? 27  ARG C CD  1 
ATOM   2138 N NE  . ARG C 1 27  ? 34.79301 -5.02790  -10.27125 1.000 49.80798  ? 27  ARG C NE  1 
ATOM   2139 C CZ  . ARG C 1 27  ? 33.58844 -5.43895  -9.90140  1.000 44.19205  ? 27  ARG C CZ  1 
ATOM   2140 N NH1 . ARG C 1 27  ? 32.49953 -4.75409  -10.20994 1.000 45.61686  ? 27  ARG C NH1 1 
ATOM   2141 N NH2 . ARG C 1 27  ? 33.47254 -6.57098  -9.21533  1.000 45.73020  ? 27  ARG C NH2 1 
ATOM   2142 N N   . VAL C 1 28  ? 38.89664 0.16363   -11.85579 1.000 42.42626  ? 28  VAL C N   1 
ATOM   2143 C CA  . VAL C 1 28  ? 40.17510 0.60417   -12.40246 1.000 43.96074  ? 28  VAL C CA  1 
ATOM   2144 C C   . VAL C 1 28  ? 40.82550 1.61339   -11.46761 1.000 45.01730  ? 28  VAL C C   1 
ATOM   2145 O O   . VAL C 1 28  ? 42.05708 1.66702   -11.35708 1.000 48.81752  ? 28  VAL C O   1 
ATOM   2146 C CB  . VAL C 1 28  ? 39.98323 1.17891   -13.81935 1.000 42.35361  ? 28  VAL C CB  1 
ATOM   2147 C CG1 . VAL C 1 28  ? 41.30828 1.64979   -14.39036 1.000 43.15862  ? 28  VAL C CG1 1 
ATOM   2148 C CG2 . VAL C 1 28  ? 39.34926 0.14137   -14.73480 1.000 39.48628  ? 28  VAL C CG2 1 
ATOM   2149 N N   . SER C 1 29  ? 40.01677 2.42114   -10.77707 1.000 44.36498  ? 29  SER C N   1 
ATOM   2150 C CA  . SER C 1 29  ? 40.55498 3.32403   -9.76497  1.000 47.79651  ? 29  SER C CA  1 
ATOM   2151 C C   . SER C 1 29  ? 41.34072 2.55918   -8.70809  1.000 46.10777  ? 29  SER C C   1 
ATOM   2152 O O   . SER C 1 29  ? 42.44372 2.96932   -8.32613  1.000 47.22185  ? 29  SER C O   1 
ATOM   2153 C CB  . SER C 1 29  ? 39.42194 4.11930   -9.11712  1.000 39.82428  ? 29  SER C CB  1 
ATOM   2154 O OG  . SER C 1 29  ? 39.91311 4.95648   -8.08873  1.000 40.78170  ? 29  SER C OG  1 
ATOM   2155 N N   . ASP C 1 30  ? 40.79252 1.43687   -8.23210  1.000 45.00783  ? 30  ASP C N   1 
ATOM   2156 C CA  . ASP C 1 30  ? 41.48543 0.64385   -7.22006  1.000 47.42634  ? 30  ASP C CA  1 
ATOM   2157 C C   . ASP C 1 30  ? 42.79626 0.08499   -7.75791  1.000 45.96542  ? 30  ASP C C   1 
ATOM   2158 O O   . ASP C 1 30  ? 43.79637 0.01813   -7.03256  1.000 45.62689  ? 30  ASP C O   1 
ATOM   2159 C CB  . ASP C 1 30  ? 40.58327 -0.48829  -6.72831  1.000 42.11825  ? 30  ASP C CB  1 
ATOM   2160 C CG  . ASP C 1 30  ? 39.34660 0.02060   -6.01938  1.000 46.80045  ? 30  ASP C CG  1 
ATOM   2161 O OD1 . ASP C 1 30  ? 39.23368 1.25089   -5.82586  1.000 45.37381  ? 30  ASP C OD1 1 
ATOM   2162 O OD2 . ASP C 1 30  ? 38.48599 -0.80837  -5.65725  1.000 45.98635  ? 30  ASP C OD2 1 
ATOM   2163 N N   . LEU C 1 31  ? 42.81035 -0.32191  -9.02941  1.000 45.40579  ? 31  LEU C N   1 
ATOM   2164 C CA  . LEU C 1 31  ? 44.03908 -0.82836  -9.63257  1.000 43.20082  ? 31  LEU C CA  1 
ATOM   2165 C C   . LEU C 1 31  ? 45.10337 0.25832   -9.70540  1.000 43.00538  ? 31  LEU C C   1 
ATOM   2166 O O   . LEU C 1 31  ? 46.29652 -0.01671  -9.52969  1.000 45.59224  ? 31  LEU C O   1 
ATOM   2167 C CB  . LEU C 1 31  ? 43.74425 -1.38676  -11.02383 1.000 44.53407  ? 31  LEU C CB  1 
ATOM   2168 C CG  . LEU C 1 31  ? 44.92766 -1.94621  -11.81416 1.000 47.42432  ? 31  LEU C CG  1 
ATOM   2169 C CD1 . LEU C 1 31  ? 45.60118 -3.07388  -11.05204 1.000 46.24839  ? 31  LEU C CD1 1 
ATOM   2170 C CD2 . LEU C 1 31  ? 44.48421 -2.41568  -13.19276 1.000 50.21853  ? 31  LEU C CD2 1 
ATOM   2171 N N   . ILE C 1 32  ? 44.68690 1.50121   -9.95835  1.000 45.85197  ? 32  ILE C N   1 
ATOM   2172 C CA  . ILE C 1 32  ? 45.62624 2.62089   -9.98169  1.000 48.62118  ? 32  ILE C CA  1 
ATOM   2173 C C   . ILE C 1 32  ? 46.38042 2.70732   -8.66223  1.000 47.89215  ? 32  ILE C C   1 
ATOM   2174 O O   . ILE C 1 32  ? 47.61720 2.73281   -8.63142  1.000 46.65667  ? 32  ILE C O   1 
ATOM   2175 C CB  . ILE C 1 32  ? 44.88542 3.93496   -10.28796 1.000 50.15257  ? 32  ILE C CB  1 
ATOM   2176 C CG1 . ILE C 1 32  ? 44.40158 3.95225   -11.73758 1.000 47.46457  ? 32  ILE C CG1 1 
ATOM   2177 C CG2 . ILE C 1 32  ? 45.77238 5.13412   -9.99250  1.000 42.78559  ? 32  ILE C CG2 1 
ATOM   2178 C CD1 . ILE C 1 32  ? 45.51355 4.09717   -12.74462 1.000 53.96479  ? 32  ILE C CD1 1 
ATOM   2179 N N   . TYR C 1 33  ? 45.64036 2.75341   -7.55109  1.000 49.37563  ? 33  TYR C N   1 
ATOM   2180 C CA  . TYR C 1 33  ? 46.27025 2.83227   -6.23813  1.000 45.49796  ? 33  TYR C CA  1 
ATOM   2181 C C   . TYR C 1 33  ? 47.14506 1.61456   -5.96810  1.000 53.39172  ? 33  TYR C C   1 
ATOM   2182 O O   . TYR C 1 33  ? 48.27337 1.74741   -5.47827  1.000 55.05120  ? 33  TYR C O   1 
ATOM   2183 C CB  . TYR C 1 33  ? 45.20262 2.97367   -5.15247  1.000 49.90208  ? 33  TYR C CB  1 
ATOM   2184 C CG  . TYR C 1 33  ? 45.71160 2.65214   -3.76613  1.000 50.66468  ? 33  TYR C CG  1 
ATOM   2185 C CD1 . TYR C 1 33  ? 46.43556 3.58706   -3.03962  1.000 55.87541  ? 33  TYR C CD1 1 
ATOM   2186 C CD2 . TYR C 1 33  ? 45.47163 1.41261   -3.18520  1.000 51.74837  ? 33  TYR C CD2 1 
ATOM   2187 C CE1 . TYR C 1 33  ? 46.90635 3.29892   -1.77313  1.000 56.13191  ? 33  TYR C CE1 1 
ATOM   2188 C CE2 . TYR C 1 33  ? 45.93904 1.11511   -1.91853  1.000 59.05612  ? 33  TYR C CE2 1 
ATOM   2189 C CZ  . TYR C 1 33  ? 46.65631 2.06217   -1.21793  1.000 55.87229  ? 33  TYR C CZ  1 
ATOM   2190 O OH  . TYR C 1 33  ? 47.12565 1.77363   0.04209   1.000 58.65270  ? 33  TYR C OH  1 
ATOM   2191 N N   . GLU C 1 34  ? 46.64018 0.41802   -6.27902  1.000 46.69865  ? 34  GLU C N   1 
ATOM   2192 C CA  . GLU C 1 34  ? 47.39554 -0.79853  -5.99853  1.000 53.49972  ? 34  GLU C CA  1 
ATOM   2193 C C   . GLU C 1 34  ? 48.67968 -0.85152  -6.81710  1.000 56.70327  ? 34  GLU C C   1 
ATOM   2194 O O   . GLU C 1 34  ? 49.73264 -1.25783  -6.31142  1.000 62.07617  ? 34  GLU C O   1 
ATOM   2195 C CB  . GLU C 1 34  ? 46.52822 -2.02689  -6.27622  1.000 54.50096  ? 34  GLU C CB  1 
ATOM   2196 C CG  . GLU C 1 34  ? 46.93929 -3.27283  -5.50354  1.000 68.88845  ? 34  GLU C CG  1 
ATOM   2197 C CD  . GLU C 1 34  ? 46.54416 -3.21236  -4.03513  1.000 77.81379  ? 34  GLU C CD  1 
ATOM   2198 O OE1 . GLU C 1 34  ? 45.68559 -2.37659  -3.67864  1.000 71.39642  ? 34  GLU C OE1 1 
ATOM   2199 O OE2 . GLU C 1 34  ? 47.09029 -4.00349  -3.23624  1.000 76.25139  ? 34  GLU C OE2 1 
ATOM   2200 N N   . PHE C 1 35  ? 48.61448 -0.43092  -8.08144  1.000 53.48187  ? 35  PHE C N   1 
ATOM   2201 C CA  . PHE C 1 35  ? 49.79278 -0.47320  -8.94154  1.000 58.63179  ? 35  PHE C CA  1 
ATOM   2202 C C   . PHE C 1 35  ? 50.82574 0.56527   -8.52099  1.000 59.88920  ? 35  PHE C C   1 
ATOM   2203 O O   . PHE C 1 35  ? 52.03397 0.31182   -8.59383  1.000 62.23909  ? 35  PHE C O   1 
ATOM   2204 C CB  . PHE C 1 35  ? 49.37456 -0.26936  -10.39892 1.000 54.96629  ? 35  PHE C CB  1 
ATOM   2205 C CG  . PHE C 1 35  ? 50.52339 -0.07025  -11.34269 1.000 54.92531  ? 35  PHE C CG  1 
ATOM   2206 C CD1 . PHE C 1 35  ? 51.35757 -1.12446  -11.67306 1.000 55.59964  ? 35  PHE C CD1 1 
ATOM   2207 C CD2 . PHE C 1 35  ? 50.75937 1.16969   -11.91295 1.000 57.95014  ? 35  PHE C CD2 1 
ATOM   2208 C CE1 . PHE C 1 35  ? 52.41226 -0.94259  -12.54494 1.000 60.63098  ? 35  PHE C CE1 1 
ATOM   2209 C CE2 . PHE C 1 35  ? 51.81223 1.35674   -12.78638 1.000 57.96115  ? 35  PHE C CE2 1 
ATOM   2210 C CZ  . PHE C 1 35  ? 52.63871 0.29965   -13.10281 1.000 58.73911  ? 35  PHE C CZ  1 
ATOM   2211 N N   . MET C 1 36  ? 50.37296 1.73357   -8.07028  1.000 55.97003  ? 36  MET C N   1 
ATOM   2212 C CA  . MET C 1 36  ? 51.27623 2.79652   -7.64928  1.000 63.02273  ? 36  MET C CA  1 
ATOM   2213 C C   . MET C 1 36  ? 51.88113 2.55917   -6.27243  1.000 71.83238  ? 36  MET C C   1 
ATOM   2214 O O   . MET C 1 36  ? 52.63575 3.41175   -5.79260  1.000 78.52969  ? 36  MET C O   1 
ATOM   2215 C CB  . MET C 1 36  ? 50.54840 4.14122   -7.66702  1.000 57.39282  ? 36  MET C CB  1 
ATOM   2216 C CG  . MET C 1 36  ? 50.22696 4.63672   -9.06175  1.000 55.11895  ? 36  MET C CG  1 
ATOM   2217 S SD  . MET C 1 36  ? 49.35522 6.20756   -9.04381  1.000 66.92278  ? 36  MET C SD  1 
ATOM   2218 C CE  . MET C 1 36  ? 50.48567 7.20376   -8.07402  1.000 65.17236  ? 36  MET C CE  1 
ATOM   2219 N N   . LYS C 1 37  ? 51.56730 1.43778   -5.62419  1.000 72.81434  ? 37  LYS C N   1 
ATOM   2220 C CA  . LYS C 1 37  ? 52.20467 1.07388   -4.36646  1.000 76.51642  ? 37  LYS C CA  1 
ATOM   2221 C C   . LYS C 1 37  ? 53.25211 -0.01923  -4.52359  1.000 83.60088  ? 37  LYS C C   1 
ATOM   2222 O O   . LYS C 1 37  ? 54.09350 -0.18079  -3.63266  1.000 85.46986  ? 37  LYS C O   1 
ATOM   2223 C CB  . LYS C 1 37  ? 51.15341 0.62343   -3.34474  1.000 70.27695  ? 37  LYS C CB  1 
ATOM   2224 C CG  . LYS C 1 37  ? 50.33183 1.76001   -2.76004  1.000 68.32191  ? 37  LYS C CG  1 
ATOM   2225 C CD  . LYS C 1 37  ? 51.20565 2.70726   -1.95371  1.000 73.28408  ? 37  LYS C CD  1 
ATOM   2226 C CE  . LYS C 1 37  ? 50.37618 3.78100   -1.26687  1.000 68.64422  ? 37  LYS C CE  1 
ATOM   2227 N NZ  . LYS C 1 37  ? 51.20727 4.64970   -0.38582  1.000 61.25350  ? 37  LYS C NZ  1 
ATOM   2228 N N   . LYS C 1 38  ? 53.22251 -0.76433  -5.62695  1.000 84.62933  ? 38  LYS C N   1 
ATOM   2229 C CA  . LYS C 1 38  ? 54.21180 -1.79382  -5.92732  1.000 91.15176  ? 38  LYS C CA  1 
ATOM   2230 C C   . LYS C 1 38  ? 55.10523 -1.37990  -7.09523  1.000 98.72419  ? 38  LYS C C   1 
ATOM   2231 O O   . LYS C 1 38  ? 55.38922 -2.17212  -7.99620  1.000 101.07549 ? 38  LYS C O   1 
ATOM   2232 C CB  . LYS C 1 38  ? 53.53135 -3.13070  -6.21531  1.000 86.31360  ? 38  LYS C CB  1 
ATOM   2233 C CG  . LYS C 1 38  ? 52.49232 -3.09207  -7.32984  1.000 76.98521  ? 38  LYS C CG  1 
ATOM   2234 C CD  . LYS C 1 38  ? 51.90904 -4.47345  -7.57469  1.000 72.98504  ? 38  LYS C CD  1 
ATOM   2235 C CE  . LYS C 1 38  ? 53.00286 -5.48459  -7.88237  1.000 72.01739  ? 38  LYS C CE  1 
ATOM   2236 N NZ  . LYS C 1 38  ? 52.47204 -6.87410  -7.94890  1.000 70.42113  ? 38  LYS C NZ  1 
ATOM   2237 N N   . ASP C 1 39  ? 55.56298 -0.13118  -7.08633  1.000 100.81248 ? 39  ASP C N   1 
ATOM   2238 C CA  . ASP C 1 39  ? 56.41260 0.38414   -8.15604  1.000 103.14516 ? 39  ASP C CA  1 
ATOM   2239 C C   . ASP C 1 39  ? 57.80276 -0.24427  -8.12177  1.000 110.00023 ? 39  ASP C C   1 
ATOM   2240 O O   . ASP C 1 39  ? 58.60046 -0.05826  -9.04104  1.000 112.77554 ? 39  ASP C O   1 
ATOM   2241 C CB  . ASP C 1 39  ? 56.52704 1.90785   -8.06506  1.000 98.37518  ? 39  ASP C CB  1 
ATOM   2242 C CG  . ASP C 1 39  ? 57.12083 2.37263   -6.75109  1.000 103.98519 ? 39  ASP C CG  1 
ATOM   2243 O OD1 . ASP C 1 39  ? 56.82183 1.75449   -5.70747  1.000 101.45458 ? 39  ASP C OD1 1 
ATOM   2244 O OD2 . ASP C 1 39  ? 57.88846 3.35785   -6.76338  1.000 106.91637 ? 39  ASP C OD2 1 
ATOM   2245 O OXT . ASP C 1 39  ? 58.16321 -0.94838  -7.17787  1.000 108.15946 ? 39  ASP C OXT 1 
ATOM   2246 N N   . ASN D 2 2   ? 19.17313 18.29317  28.10905  1.000 58.26222  ? 334 ASN D N   1 
ATOM   2247 C CA  . ASN D 2 2   ? 19.83681 18.47519  26.82322  1.000 66.94058  ? 334 ASN D CA  1 
ATOM   2248 C C   . ASN D 2 2   ? 20.35483 17.15523  26.26288  1.000 62.91040  ? 334 ASN D C   1 
ATOM   2249 O O   . ASN D 2 2   ? 21.37080 16.63291  26.72019  1.000 55.71762  ? 334 ASN D O   1 
ATOM   2250 C CB  . ASN D 2 2   ? 20.99091 19.47332  26.94984  1.000 63.13980  ? 334 ASN D CB  1 
ATOM   2251 C CG  . ASN D 2 2   ? 20.53833 20.91192  26.79278  1.000 71.86377  ? 334 ASN D CG  1 
ATOM   2252 O OD1 . ASN D 2 2   ? 20.64913 21.49453  25.71367  1.000 67.91612  ? 334 ASN D OD1 1 
ATOM   2253 N ND2 . ASN D 2 2   ? 20.02253 21.49234  27.87072  1.000 80.41504  ? 334 ASN D ND2 1 
ATOM   2254 N N   . LEU D 2 3   ? 19.64616 16.61886  25.27376  1.000 59.61750  ? 335 LEU D N   1 
ATOM   2255 C CA  . LEU D 2 3   ? 20.10883 15.43480  24.56803  1.000 58.82547  ? 335 LEU D CA  1 
ATOM   2256 C C   . LEU D 2 3   ? 21.11400 15.82588  23.49286  1.000 55.69442  ? 335 LEU D C   1 
ATOM   2257 O O   . LEU D 2 3   ? 21.02470 16.89862  22.88946  1.000 58.52758  ? 335 LEU D O   1 
ATOM   2258 C CB  . LEU D 2 3   ? 18.93475 14.68529  23.93735  1.000 65.17711  ? 335 LEU D CB  1 
ATOM   2259 C CG  . LEU D 2 3   ? 17.91205 14.08002  24.90021  1.000 67.18739  ? 335 LEU D CG  1 
ATOM   2260 C CD1 . LEU D 2 3   ? 16.77852 13.42282  24.12959  1.000 61.92871  ? 335 LEU D CD1 1 
ATOM   2261 C CD2 . LEU D 2 3   ? 18.58039 13.08120  25.83251  1.000 63.70076  ? 335 LEU D CD2 1 
ATOM   2262 N N   . CYS D 2 4   ? 22.07708 14.94695  23.26022  1.000 56.59227  ? 336 CYS D N   1 
ATOM   2263 C CA  . CYS D 2 4   ? 23.12696 15.24274  22.29408  1.000 54.80298  ? 336 CYS D CA  1 
ATOM   2264 C C   . CYS D 2 4   ? 22.55882 15.20343  20.88036  1.000 54.15750  ? 336 CYS D C   1 
ATOM   2265 O O   . CYS D 2 4   ? 21.83497 14.26313  20.53391  1.000 54.81260  ? 336 CYS D O   1 
ATOM   2266 C CB  . CYS D 2 4   ? 24.28293 14.25668  22.44118  1.000 54.83216  ? 336 CYS D CB  1 
ATOM   2267 S SG  . CYS D 2 4   ? 25.13739 14.37885  24.03975  1.000 55.46425  ? 336 CYS D SG  1 
ATOM   2268 N N   . PRO D 2 5   ? 22.85514 16.19845  20.04141  1.000 58.27900  ? 337 PRO D N   1 
ATOM   2269 C CA  . PRO D 2 5   ? 22.24936 16.24569  18.70369  1.000 58.14756  ? 337 PRO D CA  1 
ATOM   2270 C C   . PRO D 2 5   ? 22.82606 15.20910  17.75331  1.000 56.51849  ? 337 PRO D C   1 
ATOM   2271 O O   . PRO D 2 5   ? 23.49215 15.55875  16.77418  1.000 57.94704  ? 337 PRO D O   1 
ATOM   2272 C CB  . PRO D 2 5   ? 22.56165 17.67143  18.23333  1.000 58.98583  ? 337 PRO D CB  1 
ATOM   2273 C CG  . PRO D 2 5   ? 23.81636 18.03147  18.95982  1.000 54.98413  ? 337 PRO D CG  1 
ATOM   2274 C CD  . PRO D 2 5   ? 23.72808 17.35727  20.30065  1.000 52.84525  ? 337 PRO D CD  1 
ATOM   2275 N N   . PHE D 2 6   ? 22.57145 13.92809  18.03045  1.000 57.95867  ? 338 PHE D N   1 
ATOM   2276 C CA  . PHE D 2 6   ? 23.04973 12.87449  17.14211  1.000 56.64370  ? 338 PHE D CA  1 
ATOM   2277 C C   . PHE D 2 6   ? 22.28133 12.85417  15.82740  1.000 55.37076  ? 338 PHE D C   1 
ATOM   2278 O O   . PHE D 2 6   ? 22.81168 12.39461  14.80988  1.000 56.80000  ? 338 PHE D O   1 
ATOM   2279 C CB  . PHE D 2 6   ? 22.95303 11.51744  17.83870  1.000 56.52332  ? 338 PHE D CB  1 
ATOM   2280 C CG  . PHE D 2 6   ? 23.98866 11.31021  18.90492  1.000 54.15879  ? 338 PHE D CG  1 
ATOM   2281 C CD1 . PHE D 2 6   ? 25.31916 11.61166  18.66453  1.000 51.69277  ? 338 PHE D CD1 1 
ATOM   2282 C CD2 . PHE D 2 6   ? 23.63056 10.82515  20.15204  1.000 62.99863  ? 338 PHE D CD2 1 
ATOM   2283 C CE1 . PHE D 2 6   ? 26.27624 11.42392  19.64521  1.000 56.76635  ? 338 PHE D CE1 1 
ATOM   2284 C CE2 . PHE D 2 6   ? 24.58145 10.63648  21.13840  1.000 62.00476  ? 338 PHE D CE2 1 
ATOM   2285 C CZ  . PHE D 2 6   ? 25.90636 10.93694  20.88558  1.000 62.60880  ? 338 PHE D CZ  1 
ATOM   2286 N N   . GLY D 2 7   ? 21.04025 13.34642  15.82614  1.000 61.44932  ? 339 GLY D N   1 
ATOM   2287 C CA  . GLY D 2 7   ? 20.26072 13.36969  14.60082  1.000 59.00534  ? 339 GLY D CA  1 
ATOM   2288 C C   . GLY D 2 7   ? 20.79207 14.34565  13.57201  1.000 58.26877  ? 339 GLY D C   1 
ATOM   2289 O O   . GLY D 2 7   ? 20.64661 14.12122  12.36700  1.000 61.31815  ? 339 GLY D O   1 
ATOM   2290 N N   . GLU D 2 8   ? 21.40984 15.43890  14.02511  1.000 58.34522  ? 340 GLU D N   1 
ATOM   2291 C CA  . GLU D 2 8   ? 22.01956 16.38224  13.09472  1.000 56.91832  ? 340 GLU D CA  1 
ATOM   2292 C C   . GLU D 2 8   ? 23.16196 15.73864  12.31872  1.000 56.30202  ? 340 GLU D C   1 
ATOM   2293 O O   . GLU D 2 8   ? 23.42754 16.11889  11.17243  1.000 55.97992  ? 340 GLU D O   1 
ATOM   2294 C CB  . GLU D 2 8   ? 22.51222 17.61525  13.85402  1.000 58.79797  ? 340 GLU D CB  1 
ATOM   2295 C CG  . GLU D 2 8   ? 23.08676 18.71344  12.97501  1.000 65.74018  ? 340 GLU D CG  1 
ATOM   2296 C CD  . GLU D 2 8   ? 23.69514 19.84431  13.78223  1.000 71.34541  ? 340 GLU D CD  1 
ATOM   2297 O OE1 . GLU D 2 8   ? 23.51925 19.85431  15.01935  1.000 64.14340  ? 340 GLU D OE1 1 
ATOM   2298 O OE2 . GLU D 2 8   ? 24.35255 20.72023  13.18073  1.000 79.56271  ? 340 GLU D OE2 1 
ATOM   2299 N N   . VAL D 2 9   ? 23.83751 14.76148  12.91625  1.000 55.72285  ? 341 VAL D N   1 
ATOM   2300 C CA  . VAL D 2 9   ? 24.94496 14.07663  12.25561  1.000 57.28874  ? 341 VAL D CA  1 
ATOM   2301 C C   . VAL D 2 9   ? 24.45844 12.87114  11.46328  1.000 54.35727  ? 341 VAL D C   1 
ATOM   2302 O O   . VAL D 2 9   ? 24.79775 12.70956  10.28883  1.000 54.04066  ? 341 VAL D O   1 
ATOM   2303 C CB  . VAL D 2 9   ? 26.01299 13.67160  13.29576  1.000 53.65713  ? 341 VAL D CB  1 
ATOM   2304 C CG1 . VAL D 2 9   ? 27.10050 12.83019  12.64407  1.000 47.13003  ? 341 VAL D CG1 1 
ATOM   2305 C CG2 . VAL D 2 9   ? 26.61386 14.90607  13.94892  1.000 51.11050  ? 341 VAL D CG2 1 
ATOM   2306 N N   . PHE D 2 10  ? 23.65101 12.01126  12.08642  1.000 52.19196  ? 342 PHE D N   1 
ATOM   2307 C CA  . PHE D 2 10  ? 23.23852 10.77162  11.43647  1.000 50.96913  ? 342 PHE D CA  1 
ATOM   2308 C C   . PHE D 2 10  ? 22.13671 11.00905  10.40948  1.000 56.84299  ? 342 PHE D C   1 
ATOM   2309 O O   . PHE D 2 10  ? 22.24384 10.56411  9.26138   1.000 59.27251  ? 342 PHE D O   1 
ATOM   2310 C CB  . PHE D 2 10  ? 22.78473 9.75558   12.48599  1.000 53.85839  ? 342 PHE D CB  1 
ATOM   2311 C CG  . PHE D 2 10  ? 23.91575 9.12828   13.24889  1.000 51.43685  ? 342 PHE D CG  1 
ATOM   2312 C CD1 . PHE D 2 10  ? 24.49966 9.78868   14.31676  1.000 51.20987  ? 342 PHE D CD1 1 
ATOM   2313 C CD2 . PHE D 2 10  ? 24.39488 7.87769   12.89737  1.000 48.56763  ? 342 PHE D CD2 1 
ATOM   2314 C CE1 . PHE D 2 10  ? 25.54190 9.21476   15.01806  1.000 49.94707  ? 342 PHE D CE1 1 
ATOM   2315 C CE2 . PHE D 2 10  ? 25.43577 7.29805   13.59537  1.000 52.38049  ? 342 PHE D CE2 1 
ATOM   2316 C CZ  . PHE D 2 10  ? 26.00956 7.96788   14.65793  1.000 46.51637  ? 342 PHE D CZ  1 
ATOM   2317 N N   . ASN D 2 11  ? 21.06817 11.70104  10.80329  1.000 62.23780  ? 343 ASN D N   1 
ATOM   2318 C CA  . ASN D 2 11  ? 19.92858 11.93457  9.92543   1.000 59.03187  ? 343 ASN D CA  1 
ATOM   2319 C C   . ASN D 2 11  ? 20.11355 13.14631  9.01305   1.000 56.48118  ? 343 ASN D C   1 
ATOM   2320 O O   . ASN D 2 11  ? 19.12026 13.67954  8.50355   1.000 60.55085  ? 343 ASN D O   1 
ATOM   2321 C CB  . ASN D 2 11  ? 18.64884 12.08804  10.75419  1.000 64.28588  ? 343 ASN D CB  1 
ATOM   2322 C CG  . ASN D 2 11  ? 18.08417 10.75270  11.21540  1.000 68.18267  ? 343 ASN D CG  1 
ATOM   2323 O OD1 . ASN D 2 11  ? 18.34669 9.71374   10.61001  1.000 67.64176  ? 343 ASN D OD1 1 
ATOM   2324 N ND2 . ASN D 2 11  ? 17.29965 10.77859  12.29008  1.000 69.06326  ? 343 ASN D ND2 1 
ATOM   2325 N N   . ALA D 2 12  ? 21.34888 13.58753  8.79183   1.000 49.71012  ? 344 ALA D N   1 
ATOM   2326 C CA  . ALA D 2 12  ? 21.59347 14.70228  7.88807   1.000 51.93110  ? 344 ALA D CA  1 
ATOM   2327 C C   . ALA D 2 12  ? 21.25074 14.31339  6.45530   1.000 56.38515  ? 344 ALA D C   1 
ATOM   2328 O O   . ALA D 2 12  ? 21.48645 13.17979  6.02701   1.000 54.20323  ? 344 ALA D O   1 
ATOM   2329 C CB  . ALA D 2 12  ? 23.05128 15.15154  7.97367   1.000 49.51269  ? 344 ALA D CB  1 
ATOM   2330 N N   . THR D 2 13  ? 20.68766 15.26823  5.71228   1.000 55.44279  ? 345 THR D N   1 
ATOM   2331 C CA  . THR D 2 13  ? 20.28844 14.99782  4.33532   1.000 54.80394  ? 345 THR D CA  1 
ATOM   2332 C C   . THR D 2 13  ? 21.49558 14.65010  3.47334   1.000 55.66380  ? 345 THR D C   1 
ATOM   2333 O O   . THR D 2 13  ? 21.52824 13.59904  2.82238   1.000 58.47688  ? 345 THR D O   1 
ATOM   2334 C CB  . THR D 2 13  ? 19.54243 16.20143  3.75768   1.000 56.64188  ? 345 THR D CB  1 
ATOM   2335 O OG1 . THR D 2 13  ? 18.35601 16.44334  4.52416   1.000 56.20849  ? 345 THR D OG1 1 
ATOM   2336 C CG2 . THR D 2 13  ? 19.15607 15.93977  2.30773   1.000 56.60480  ? 345 THR D CG2 1 
ATOM   2337 N N   . ARG D 2 14  ? 22.50104 15.51746  3.46101   1.000 49.39252  ? 346 ARG D N   1 
ATOM   2338 C CA  . ARG D 2 14  ? 23.70418 15.29787  2.67641   1.000 57.22617  ? 346 ARG D CA  1 
ATOM   2339 C C   . ARG D 2 14  ? 24.90841 15.13557  3.59363   1.000 52.34494  ? 346 ARG D C   1 
ATOM   2340 O O   . ARG D 2 14  ? 24.96267 15.70513  4.68663   1.000 51.16531  ? 346 ARG D O   1 
ATOM   2341 C CB  . ARG D 2 14  ? 23.94611 16.45091  1.69499   1.000 64.06057  ? 346 ARG D CB  1 
ATOM   2342 C CG  . ARG D 2 14  ? 22.81155 16.66784  0.70426   1.000 64.68295  ? 346 ARG D CG  1 
ATOM   2343 C CD  . ARG D 2 14  ? 23.19226 17.68959  -0.35395  1.000 69.95482  ? 346 ARG D CD  1 
ATOM   2344 N NE  . ARG D 2 14  ? 23.67554 18.93256  0.23487   1.000 71.75014  ? 346 ARG D NE  1 
ATOM   2345 C CZ  . ARG D 2 14  ? 22.90461 19.96807  0.53698   1.000 76.97449  ? 346 ARG D CZ  1 
ATOM   2346 N NH1 . ARG D 2 14  ? 21.60015 19.94577  0.31737   1.000 80.22379  ? 346 ARG D NH1 1 
ATOM   2347 N NH2 . ARG D 2 14  ? 23.45652 21.05346  1.07245   1.000 76.21833  ? 346 ARG D NH2 1 
ATOM   2348 N N   . PHE D 2 15  ? 25.87136 14.34704  3.13367   1.000 53.88514  ? 347 PHE D N   1 
ATOM   2349 C CA  . PHE D 2 15  ? 27.12162 14.10800  3.83402   1.000 40.32964  ? 347 PHE D CA  1 
ATOM   2350 C C   . PHE D 2 15  ? 28.27521 14.72102  3.05215   1.000 48.88281  ? 347 PHE D C   1 
ATOM   2351 O O   . PHE D 2 15  ? 28.12708 15.15284  1.90527   1.000 50.70942  ? 347 PHE D O   1 
ATOM   2352 C CB  . PHE D 2 15  ? 27.35037 12.60632  4.03728   1.000 44.72503  ? 347 PHE D CB  1 
ATOM   2353 C CG  . PHE D 2 15  ? 26.74209 12.06116  5.29965   1.000 47.49468  ? 347 PHE D CG  1 
ATOM   2354 C CD1 . PHE D 2 15  ? 25.42553 12.33828  5.63106   1.000 53.52807  ? 347 PHE D CD1 1 
ATOM   2355 C CD2 . PHE D 2 15  ? 27.48505 11.25645  6.14750   1.000 44.73444  ? 347 PHE D CD2 1 
ATOM   2356 C CE1 . PHE D 2 15  ? 24.86564 11.83247  6.79372   1.000 49.63805  ? 347 PHE D CE1 1 
ATOM   2357 C CE2 . PHE D 2 15  ? 26.93048 10.74509  7.30737   1.000 46.42678  ? 347 PHE D CE2 1 
ATOM   2358 C CZ  . PHE D 2 15  ? 25.61864 11.03470  7.63039   1.000 45.55815  ? 347 PHE D CZ  1 
ATOM   2359 N N   . ALA D 2 16  ? 29.43740 14.75449  3.68975   1.000 44.46920  ? 348 ALA D N   1 
ATOM   2360 C CA  . ALA D 2 16  ? 30.63530 15.27791  3.05732   1.000 50.14841  ? 348 ALA D CA  1 
ATOM   2361 C C   . ALA D 2 16  ? 31.35206 14.17689  2.27869   1.000 49.68841  ? 348 ALA D C   1 
ATOM   2362 O O   . ALA D 2 16  ? 31.00408 12.99642  2.34983   1.000 50.20121  ? 348 ALA D O   1 
ATOM   2363 C CB  . ALA D 2 16  ? 31.56717 15.89120  4.10432   1.000 41.93687  ? 348 ALA D CB  1 
ATOM   2364 N N   . SER D 2 17  ? 32.36038 14.58145  1.51511   1.000 48.35931  ? 349 SER D N   1 
ATOM   2365 C CA  . SER D 2 17  ? 33.23857 13.63605  0.84633   1.000 48.30556  ? 349 SER D CA  1 
ATOM   2366 C C   . SER D 2 17  ? 34.38351 13.26375  1.77714   1.000 41.39145  ? 349 SER D C   1 
ATOM   2367 O O   . SER D 2 17  ? 34.82403 14.07024  2.59774   1.000 46.59317  ? 349 SER D O   1 
ATOM   2368 C CB  . SER D 2 17  ? 33.78439 14.21887  -0.45870  1.000 47.33478  ? 349 SER D CB  1 
ATOM   2369 O OG  . SER D 2 17  ? 32.73700 14.48932  -1.37364  1.000 49.48866  ? 349 SER D OG  1 
ATOM   2370 N N   . VAL D 2 18  ? 34.86466 12.02589  1.63888   1.000 44.43079  ? 350 VAL D N   1 
ATOM   2371 C CA  . VAL D 2 18  ? 35.83009 11.48864  2.59485   1.000 40.46895  ? 350 VAL D CA  1 
ATOM   2372 C C   . VAL D 2 18  ? 37.11294 12.31156  2.61763   1.000 42.19362  ? 350 VAL D C   1 
ATOM   2373 O O   . VAL D 2 18  ? 37.74234 12.46015  3.67287   1.000 42.40541  ? 350 VAL D O   1 
ATOM   2374 C CB  . VAL D 2 18  ? 36.10897 10.00221  2.28954   1.000 44.80185  ? 350 VAL D CB  1 
ATOM   2375 C CG1 . VAL D 2 18  ? 36.68681 9.82846   0.88722   1.000 33.63470  ? 350 VAL D CG1 1 
ATOM   2376 C CG2 . VAL D 2 18  ? 37.03002 9.40084   3.34424   1.000 35.38192  ? 350 VAL D CG2 1 
ATOM   2377 N N   . TYR D 2 19  ? 37.51911 12.87198  1.47479   1.000 41.54693  ? 351 TYR D N   1 
ATOM   2378 C CA  . TYR D 2 19  ? 38.72404 13.69487  1.47025   1.000 41.39669  ? 351 TYR D CA  1 
ATOM   2379 C C   . TYR D 2 19  ? 38.49126 15.02080  2.18264   1.000 43.74041  ? 351 TYR D C   1 
ATOM   2380 O O   . TYR D 2 19  ? 39.42951 15.59025  2.75123   1.000 39.68329  ? 351 TYR D O   1 
ATOM   2381 C CB  . TYR D 2 19  ? 39.20964 13.92545  0.03709   1.000 42.11422  ? 351 TYR D CB  1 
ATOM   2382 C CG  . TYR D 2 19  ? 38.66220 15.16918  -0.62627  1.000 42.66161  ? 351 TYR D CG  1 
ATOM   2383 C CD1 . TYR D 2 19  ? 37.40162 15.17339  -1.20794  1.000 44.70009  ? 351 TYR D CD1 1 
ATOM   2384 C CD2 . TYR D 2 19  ? 39.41376 16.33577  -0.68406  1.000 45.20942  ? 351 TYR D CD2 1 
ATOM   2385 C CE1 . TYR D 2 19  ? 36.90140 16.30598  -1.81881  1.000 42.33594  ? 351 TYR D CE1 1 
ATOM   2386 C CE2 . TYR D 2 19  ? 38.92069 17.47320  -1.29136  1.000 43.62661  ? 351 TYR D CE2 1 
ATOM   2387 C CZ  . TYR D 2 19  ? 37.66452 17.45252  -1.85518  1.000 42.29346  ? 351 TYR D CZ  1 
ATOM   2388 O OH  . TYR D 2 19  ? 37.17258 18.58250  -2.46425  1.000 51.97987  ? 351 TYR D OH  1 
ATOM   2389 N N   . ALA D 2 20  ? 37.25505 15.51983  2.17040   1.000 42.95421  ? 352 ALA D N   1 
ATOM   2390 C CA  . ALA D 2 20  ? 36.90536 16.72858  2.90593   1.000 43.51950  ? 352 ALA D CA  1 
ATOM   2391 C C   . ALA D 2 20  ? 35.91846 16.40512  4.01940   1.000 39.66972  ? 352 ALA D C   1 
ATOM   2392 O O   . ALA D 2 20  ? 34.88946 17.07508  4.15865   1.000 40.28244  ? 352 ALA D O   1 
ATOM   2393 C CB  . ALA D 2 20  ? 36.31679 17.77953  1.96614   1.000 44.72345  ? 352 ALA D CB  1 
ATOM   2394 N N   . TRP D 2 21  ? 36.22494 15.37442  4.80530   1.000 39.45446  ? 353 TRP D N   1 
ATOM   2395 C CA  . TRP D 2 21  ? 35.31437 14.91329  5.84553   1.000 42.53699  ? 353 TRP D CA  1 
ATOM   2396 C C   . TRP D 2 21  ? 34.95722 16.04146  6.80417   1.000 38.03354  ? 353 TRP D C   1 
ATOM   2397 O O   . TRP D 2 21  ? 35.79028 16.89015  7.13183   1.000 39.44915  ? 353 TRP D O   1 
ATOM   2398 C CB  . TRP D 2 21  ? 35.93813 13.74680  6.61354   1.000 39.91172  ? 353 TRP D CB  1 
ATOM   2399 C CG  . TRP D 2 21  ? 37.35962 13.97844  7.03671   1.000 38.64977  ? 353 TRP D CG  1 
ATOM   2400 C CD1 . TRP D 2 21  ? 38.47805 13.82696  6.27032   1.000 40.85787  ? 353 TRP D CD1 1 
ATOM   2401 C CD2 . TRP D 2 21  ? 37.81539 14.38505  8.33329   1.000 45.41204  ? 353 TRP D CD2 1 
ATOM   2402 N NE1 . TRP D 2 21  ? 39.60114 14.12211  7.00381   1.000 41.98531  ? 353 TRP D NE1 1 
ATOM   2403 C CE2 . TRP D 2 21  ? 39.22199 14.46703  8.27465   1.000 44.26439  ? 353 TRP D CE2 1 
ATOM   2404 C CE3 . TRP D 2 21  ? 37.17113 14.68978  9.53683   1.000 41.15468  ? 353 TRP D CE3 1 
ATOM   2405 C CZ2 . TRP D 2 21  ? 39.99447 14.83949  9.37244   1.000 46.51459  ? 353 TRP D CZ2 1 
ATOM   2406 C CZ3 . TRP D 2 21  ? 37.94084 15.06087  10.62604  1.000 45.11109  ? 353 TRP D CZ3 1 
ATOM   2407 C CH2 . TRP D 2 21  ? 39.33732 15.13217  10.53640  1.000 46.43945  ? 353 TRP D CH2 1 
ATOM   2408 N N   . ASN D 2 22  ? 33.70110 16.05052  7.23950   1.000 31.95802  ? 354 ASN D N   1 
ATOM   2409 C CA  . ASN D 2 22  ? 33.18078 17.05925  8.14935   1.000 40.54697  ? 354 ASN D CA  1 
ATOM   2410 C C   . ASN D 2 22  ? 33.23862 16.54567  9.58320   1.000 43.90607  ? 354 ASN D C   1 
ATOM   2411 O O   . ASN D 2 22  ? 33.01184 15.35899  9.83866   1.000 41.93210  ? 354 ASN D O   1 
ATOM   2412 C CB  . ASN D 2 22  ? 31.74148 17.42776  7.78011   1.000 39.54879  ? 354 ASN D CB  1 
ATOM   2413 C CG  . ASN D 2 22  ? 31.10593 18.38067  8.77665   1.000 50.84915  ? 354 ASN D CG  1 
ATOM   2414 O OD1 . ASN D 2 22  ? 30.49466 17.95464  9.75727   1.000 49.61409  ? 354 ASN D OD1 1 
ATOM   2415 N ND2 . ASN D 2 22  ? 31.24765 19.67831  8.52928   1.000 56.49120  ? 354 ASN D ND2 1 
ATOM   2416 N N   . ARG D 2 23  ? 33.54289 17.44657  10.51593  1.000 46.48023  ? 355 ARG D N   1 
ATOM   2417 C CA  . ARG D 2 23  ? 33.64666 17.12036  11.93394  1.000 41.71419  ? 355 ARG D CA  1 
ATOM   2418 C C   . ARG D 2 23  ? 32.67465 17.98630  12.72028  1.000 44.50430  ? 355 ARG D C   1 
ATOM   2419 O O   . ARG D 2 23  ? 32.75294 19.21848  12.66831  1.000 45.24339  ? 355 ARG D O   1 
ATOM   2420 C CB  . ARG D 2 23  ? 35.07360 17.32486  12.44291  1.000 41.08443  ? 355 ARG D CB  1 
ATOM   2421 C CG  . ARG D 2 23  ? 35.18990 17.31685  13.95806  1.000 40.15199  ? 355 ARG D CG  1 
ATOM   2422 C CD  . ARG D 2 23  ? 36.63986 17.23393  14.39523  1.000 35.90352  ? 355 ARG D CD  1 
ATOM   2423 N NE  . ARG D 2 23  ? 37.20055 15.91099  14.15229  1.000 37.03677  ? 355 ARG D NE  1 
ATOM   2424 C CZ  . ARG D 2 23  ? 38.47760 15.59576  14.31680  1.000 41.71348  ? 355 ARG D CZ  1 
ATOM   2425 N NH1 . ARG D 2 23  ? 39.36595 16.49280  14.71248  1.000 43.56222  ? 355 ARG D NH1 1 
ATOM   2426 N NH2 . ARG D 2 23  ? 38.87387 14.34936  14.07633  1.000 46.29875  ? 355 ARG D NH2 1 
ATOM   2427 N N   . LYS D 2 24  ? 31.76627 17.34319  13.44557  1.000 41.59331  ? 356 LYS D N   1 
ATOM   2428 C CA  . LYS D 2 24  ? 30.80611 18.02517  14.30077  1.000 44.93720  ? 356 LYS D CA  1 
ATOM   2429 C C   . LYS D 2 24  ? 31.18228 17.78623  15.75723  1.000 49.11332  ? 356 LYS D C   1 
ATOM   2430 O O   . LYS D 2 24  ? 31.41731 16.64253  16.16240  1.000 43.22340  ? 356 LYS D O   1 
ATOM   2431 C CB  . LYS D 2 24  ? 29.38361 17.53056  14.02749  1.000 46.27804  ? 356 LYS D CB  1 
ATOM   2432 C CG  . LYS D 2 24  ? 28.30951 18.23033  14.84492  1.000 54.82908  ? 356 LYS D CG  1 
ATOM   2433 C CD  . LYS D 2 24  ? 28.09327 19.65683  14.36568  1.000 63.32180  ? 356 LYS D CD  1 
ATOM   2434 C CE  . LYS D 2 24  ? 27.10495 20.39988  15.25134  1.000 66.08009  ? 356 LYS D CE  1 
ATOM   2435 N NZ  . LYS D 2 24  ? 27.65934 20.65288  16.60782  1.000 52.20807  ? 356 LYS D NZ  1 
ATOM   2436 N N   . ARG D 2 25  ? 31.24553 18.86138  16.53774  1.000 53.38210  ? 357 ARG D N   1 
ATOM   2437 C CA  . ARG D 2 25  ? 31.61303 18.76705  17.94370  1.000 49.35936  ? 357 ARG D CA  1 
ATOM   2438 C C   . ARG D 2 25  ? 30.35756 18.65992  18.79959  1.000 53.85814  ? 357 ARG D C   1 
ATOM   2439 O O   . ARG D 2 25  ? 29.42862 19.46155  18.65742  1.000 53.50817  ? 357 ARG D O   1 
ATOM   2440 C CB  . ARG D 2 25  ? 32.44738 19.97327  18.37345  1.000 48.32885  ? 357 ARG D CB  1 
ATOM   2441 C CG  . ARG D 2 25  ? 33.09943 19.80513  19.73898  1.000 56.17721  ? 357 ARG D CG  1 
ATOM   2442 C CD  . ARG D 2 25  ? 32.69876 20.91879  20.68639  1.000 57.48001  ? 357 ARG D CD  1 
ATOM   2443 N NE  . ARG D 2 25  ? 33.08133 22.23049  20.17860  1.000 61.17371  ? 357 ARG D NE  1 
ATOM   2444 C CZ  . ARG D 2 25  ? 32.74699 23.37846  20.75124  1.000 63.68532  ? 357 ARG D CZ  1 
ATOM   2445 N NH1 . ARG D 2 25  ? 32.01854 23.41284  21.85480  1.000 57.38104  ? 357 ARG D NH1 1 
ATOM   2446 N NH2 . ARG D 2 25  ? 33.15196 24.52030  20.20214  1.000 67.72971  ? 357 ARG D NH2 1 
ATOM   2447 N N   . ILE D 2 26  ? 30.33573 17.66979  19.68639  1.000 46.82037  ? 358 ILE D N   1 
ATOM   2448 C CA  . ILE D 2 26  ? 29.19051 17.39845  20.54549  1.000 47.93787  ? 358 ILE D CA  1 
ATOM   2449 C C   . ILE D 2 26  ? 29.63010 17.59053  21.98896  1.000 49.07037  ? 358 ILE D C   1 
ATOM   2450 O O   . ILE D 2 26  ? 30.58768 16.95102  22.44346  1.000 50.63451  ? 358 ILE D O   1 
ATOM   2451 C CB  . ILE D 2 26  ? 28.63082 15.98629  20.31627  1.000 46.38598  ? 358 ILE D CB  1 
ATOM   2452 C CG1 . ILE D 2 26  ? 28.05070 15.87870  18.90300  1.000 51.41765  ? 358 ILE D CG1 1 
ATOM   2453 C CG2 . ILE D 2 26  ? 27.57874 15.65397  21.35263  1.000 39.99878  ? 358 ILE D CG2 1 
ATOM   2454 C CD1 . ILE D 2 26  ? 27.43204 14.53939  18.59235  1.000 47.45469  ? 358 ILE D CD1 1 
ATOM   2455 N N   . SER D 2 27  ? 28.93730 18.47151  22.70558  1.000 47.80786  ? 359 SER D N   1 
ATOM   2456 C CA  . SER D 2 27  ? 29.29919 18.77057  24.08309  1.000 50.14548  ? 359 SER D CA  1 
ATOM   2457 C C   . SER D 2 27  ? 28.09230 19.34530  24.80903  1.000 50.66963  ? 359 SER D C   1 
ATOM   2458 O O   . SER D 2 27  ? 27.11505 19.77208  24.18731  1.000 52.06480  ? 359 SER D O   1 
ATOM   2459 C CB  . SER D 2 27  ? 30.48581 19.73770  24.14880  1.000 54.18985  ? 359 SER D CB  1 
ATOM   2460 O OG  . SER D 2 27  ? 30.31137 20.82605  23.26040  1.000 56.39965  ? 359 SER D OG  1 
ATOM   2461 N N   . ASN D 2 28  ? 28.17667 19.33727  26.14195  1.000 48.86989  ? 360 ASN D N   1 
ATOM   2462 C CA  . ASN D 2 28  ? 27.15581 19.91245  27.01883  1.000 47.78967  ? 360 ASN D CA  1 
ATOM   2463 C C   . ASN D 2 28  ? 25.79780 19.24310  26.79695  1.000 47.52376  ? 360 ASN D C   1 
ATOM   2464 O O   . ASN D 2 28  ? 24.78979 19.89461  26.51366  1.000 49.92621  ? 360 ASN D O   1 
ATOM   2465 C CB  . ASN D 2 28  ? 27.06085 21.42997  26.82278  1.000 49.25158  ? 360 ASN D CB  1 
ATOM   2466 C CG  . ASN D 2 28  ? 28.40144 22.12035  26.96471  1.000 54.53037  ? 360 ASN D CG  1 
ATOM   2467 O OD1 . ASN D 2 28  ? 29.23750 21.71684  27.77169  1.000 52.68832  ? 360 ASN D OD1 1 
ATOM   2468 N ND2 . ASN D 2 28  ? 28.61549 23.16587  26.17374  1.000 62.05511  ? 360 ASN D ND2 1 
ATOM   2469 N N   . CYS D 2 29  ? 25.78553 17.92113  26.94179  1.000 40.59241  ? 361 CYS D N   1 
ATOM   2470 C CA  . CYS D 2 29  ? 24.58002 17.14557  26.67802  1.000 44.63894  ? 361 CYS D CA  1 
ATOM   2471 C C   . CYS D 2 29  ? 24.75332 15.74733  27.25224  1.000 44.69595  ? 361 CYS D C   1 
ATOM   2472 O O   . CYS D 2 29  ? 25.86007 15.32694  27.60103  1.000 42.95297  ? 361 CYS D O   1 
ATOM   2473 C CB  . CYS D 2 29  ? 24.27834 17.07561  25.17861  1.000 55.94834  ? 361 CYS D CB  1 
ATOM   2474 S SG  . CYS D 2 29  ? 25.61442 16.34981  24.19477  1.000 49.22841  ? 361 CYS D SG  1 
ATOM   2475 N N   . VAL D 2 30  ? 23.63388 15.03177  27.34049  1.000 52.36744  ? 362 VAL D N   1 
ATOM   2476 C CA  . VAL D 2 30  ? 23.60178 13.63262  27.74656  1.000 51.98843  ? 362 VAL D CA  1 
ATOM   2477 C C   . VAL D 2 30  ? 23.36721 12.78390  26.50501  1.000 54.09978  ? 362 VAL D C   1 
ATOM   2478 O O   . VAL D 2 30  ? 22.51356 13.10865  25.67117  1.000 50.70285  ? 362 VAL D O   1 
ATOM   2479 C CB  . VAL D 2 30  ? 22.51156 13.37571  28.80493  1.000 54.37531  ? 362 VAL D CB  1 
ATOM   2480 C CG1 . VAL D 2 30  ? 22.55746 11.92855  29.27744  1.000 49.80677  ? 362 VAL D CG1 1 
ATOM   2481 C CG2 . VAL D 2 30  ? 22.67355 14.33317  29.97427  1.000 47.71324  ? 362 VAL D CG2 1 
ATOM   2482 N N   . ALA D 2 31  ? 24.12845 11.70017  26.37978  1.000 54.92581  ? 363 ALA D N   1 
ATOM   2483 C CA  . ALA D 2 31  ? 24.09961 10.84997  25.19823  1.000 62.86958  ? 363 ALA D CA  1 
ATOM   2484 C C   . ALA D 2 31  ? 23.61393 9.45774   25.57321  1.000 59.67303  ? 363 ALA D C   1 
ATOM   2485 O O   . ALA D 2 31  ? 24.17527 8.81922   26.46956  1.000 51.44430  ? 363 ALA D O   1 
ATOM   2486 C CB  . ALA D 2 31  ? 25.48428 10.77096  24.55027  1.000 60.96420  ? 363 ALA D CB  1 
ATOM   2487 N N   . ASP D 2 32  ? 22.57831 8.98883   24.88280  1.000 60.55775  ? 364 ASP D N   1 
ATOM   2488 C CA  . ASP D 2 32  ? 22.07651 7.62764   25.04876  1.000 63.06462  ? 364 ASP D CA  1 
ATOM   2489 C C   . ASP D 2 32  ? 22.57225 6.81206   23.85933  1.000 64.19043  ? 364 ASP D C   1 
ATOM   2490 O O   . ASP D 2 32  ? 21.97653 6.83922   22.77964  1.000 58.84218  ? 364 ASP D O   1 
ATOM   2491 C CB  . ASP D 2 32  ? 20.55538 7.60970   25.15409  1.000 60.30073  ? 364 ASP D CB  1 
ATOM   2492 C CG  . ASP D 2 32  ? 20.02602 6.30786   25.73127  1.000 67.57774  ? 364 ASP D CG  1 
ATOM   2493 O OD1 . ASP D 2 32  ? 20.61641 5.24127   25.45497  1.000 67.98495  ? 364 ASP D OD1 1 
ATOM   2494 O OD2 . ASP D 2 32  ? 19.01782 6.35124   26.46751  1.000 72.31544  ? 364 ASP D OD2 1 
ATOM   2495 N N   . TYR D 2 33  ? 23.67116 6.08831   24.06084  1.000 62.12534  ? 365 TYR D N   1 
ATOM   2496 C CA  . TYR D 2 33  ? 24.25341 5.26412   23.01145  1.000 59.07991  ? 365 TYR D CA  1 
ATOM   2497 C C   . TYR D 2 33  ? 23.47886 3.97424   22.77376  1.000 65.96946  ? 365 TYR D C   1 
ATOM   2498 O O   . TYR D 2 33  ? 23.84378 3.20858   21.87571  1.000 66.52954  ? 365 TYR D O   1 
ATOM   2499 C CB  . TYR D 2 33  ? 25.71337 4.94912   23.34677  1.000 57.80395  ? 365 TYR D CB  1 
ATOM   2500 C CG  . TYR D 2 33  ? 26.57146 6.18369   23.53145  1.000 61.32569  ? 365 TYR D CG  1 
ATOM   2501 C CD1 . TYR D 2 33  ? 27.21199 6.77873   22.45052  1.000 56.18036  ? 365 TYR D CD1 1 
ATOM   2502 C CD2 . TYR D 2 33  ? 26.73738 6.75692   24.78684  1.000 61.86006  ? 365 TYR D CD2 1 
ATOM   2503 C CE1 . TYR D 2 33  ? 27.99596 7.90683   22.61579  1.000 51.93627  ? 365 TYR D CE1 1 
ATOM   2504 C CE2 . TYR D 2 33  ? 27.51963 7.88239   24.96253  1.000 58.21954  ? 365 TYR D CE2 1 
ATOM   2505 C CZ  . TYR D 2 33  ? 28.14554 8.45429   23.87510  1.000 62.09131  ? 365 TYR D CZ  1 
ATOM   2506 O OH  . TYR D 2 33  ? 28.92311 9.57634   24.05271  1.000 52.28439  ? 365 TYR D OH  1 
ATOM   2507 N N   . SER D 2 34  ? 22.43126 3.71007   23.55402  1.000 70.00979  ? 366 SER D N   1 
ATOM   2508 C CA  . SER D 2 34  ? 21.53522 2.59753   23.26728  1.000 69.29466  ? 366 SER D CA  1 
ATOM   2509 C C   . SER D 2 34  ? 20.46103 2.98926   22.26243  1.000 67.23665  ? 366 SER D C   1 
ATOM   2510 O O   . SER D 2 34  ? 20.18218 2.23122   21.32733  1.000 71.91007  ? 366 SER D O   1 
ATOM   2511 C CB  . SER D 2 34  ? 20.88585 2.08691   24.55731  1.000 65.81340  ? 366 SER D CB  1 
ATOM   2512 O OG  . SER D 2 34  ? 21.84110 1.46477   25.39905  1.000 73.50532  ? 366 SER D OG  1 
ATOM   2513 N N   . VAL D 2 35  ? 19.85495 4.16783   22.43200  1.000 64.25600  ? 367 VAL D N   1 
ATOM   2514 C CA  . VAL D 2 35  ? 18.88435 4.65476   21.45938  1.000 64.86901  ? 367 VAL D CA  1 
ATOM   2515 C C   . VAL D 2 35  ? 19.53876 5.07665   20.15701  1.000 66.41972  ? 367 VAL D C   1 
ATOM   2516 O O   . VAL D 2 35  ? 18.83349 5.37916   19.19061  1.000 73.25372  ? 367 VAL D O   1 
ATOM   2517 C CB  . VAL D 2 35  ? 18.06698 5.83598   22.02087  1.000 67.80226  ? 367 VAL D CB  1 
ATOM   2518 C CG1 . VAL D 2 35  ? 17.60515 5.53727   23.44016  1.000 66.45586  ? 367 VAL D CG1 1 
ATOM   2519 C CG2 . VAL D 2 35  ? 18.87236 7.12564   21.95853  1.000 60.25842  ? 367 VAL D CG2 1 
ATOM   2520 N N   . LEU D 2 36  ? 20.86943 5.12044   20.11402  1.000 67.23977  ? 368 LEU D N   1 
ATOM   2521 C CA  . LEU D 2 36  ? 21.60417 5.35712   18.87901  1.000 67.02974  ? 368 LEU D CA  1 
ATOM   2522 C C   . LEU D 2 36  ? 21.98091 4.05184   18.19264  1.000 63.93759  ? 368 LEU D C   1 
ATOM   2523 O O   . LEU D 2 36  ? 21.84175 3.93013   16.97140  1.000 68.61019  ? 368 LEU D O   1 
ATOM   2524 C CB  . LEU D 2 36  ? 22.86402 6.17969   19.16523  1.000 65.99434  ? 368 LEU D CB  1 
ATOM   2525 C CG  . LEU D 2 36  ? 23.80779 6.43161   17.98860  1.000 52.40173  ? 368 LEU D CG  1 
ATOM   2526 C CD1 . LEU D 2 36  ? 23.15961 7.35390   16.96888  1.000 60.22407  ? 368 LEU D CD1 1 
ATOM   2527 C CD2 . LEU D 2 36  ? 25.13368 6.99932   18.47059  1.000 49.68235  ? 368 LEU D CD2 1 
ATOM   2528 N N   . TYR D 2 37  ? 22.44738 3.06916   18.96654  1.000 66.11913  ? 369 TYR D N   1 
ATOM   2529 C CA  . TYR D 2 37  ? 22.83580 1.77826   18.41121  1.000 66.88864  ? 369 TYR D CA  1 
ATOM   2530 C C   . TYR D 2 37  ? 21.65529 1.02374   17.81282  1.000 72.86214  ? 369 TYR D C   1 
ATOM   2531 O O   . TYR D 2 37  ? 21.85765 0.16543   16.94615  1.000 68.77099  ? 369 TYR D O   1 
ATOM   2532 C CB  . TYR D 2 37  ? 23.50807 0.93663   19.50066  1.000 66.89878  ? 369 TYR D CB  1 
ATOM   2533 C CG  . TYR D 2 37  ? 23.88277 -0.46813  19.08277  1.000 70.09543  ? 369 TYR D CG  1 
ATOM   2534 C CD1 . TYR D 2 37  ? 25.05977 -0.71676  18.38960  1.000 68.19299  ? 369 TYR D CD1 1 
ATOM   2535 C CD2 . TYR D 2 37  ? 23.06615 -1.54777  19.39498  1.000 72.43244  ? 369 TYR D CD2 1 
ATOM   2536 C CE1 . TYR D 2 37  ? 25.40870 -1.99918  18.00935  1.000 63.52905  ? 369 TYR D CE1 1 
ATOM   2537 C CE2 . TYR D 2 37  ? 23.40623 -2.83337  19.01825  1.000 73.92310  ? 369 TYR D CE2 1 
ATOM   2538 C CZ  . TYR D 2 37  ? 24.57853 -3.05269  18.32612  1.000 67.91177  ? 369 TYR D CZ  1 
ATOM   2539 O OH  . TYR D 2 37  ? 24.92269 -4.33010  17.94917  1.000 72.34781  ? 369 TYR D OH  1 
ATOM   2540 N N   . ASN D 2 38  ? 20.42971 1.32996   18.24092  1.000 75.86328  ? 370 ASN D N   1 
ATOM   2541 C CA  . ASN D 2 38  ? 19.24993 0.58835   17.81177  1.000 78.41231  ? 370 ASN D CA  1 
ATOM   2542 C C   . ASN D 2 38  ? 18.24039 1.44986   17.06199  1.000 73.20213  ? 370 ASN D C   1 
ATOM   2543 O O   . ASN D 2 38  ? 17.13548 0.97532   16.77386  1.000 76.89093  ? 370 ASN D O   1 
ATOM   2544 C CB  . ASN D 2 38  ? 18.57491 -0.07071  19.01948  1.000 74.81424  ? 370 ASN D CB  1 
ATOM   2545 C CG  . ASN D 2 38  ? 19.53053 -0.93416  19.82332  1.000 77.88484  ? 370 ASN D CG  1 
ATOM   2546 O OD1 . ASN D 2 38  ? 19.68977 -2.12452  19.55123  1.000 81.53342  ? 370 ASN D OD1 1 
ATOM   2547 N ND2 . ASN D 2 38  ? 20.17093 -0.33619  20.82209  1.000 74.86029  ? 370 ASN D ND2 1 
ATOM   2548 N N   . SER D 2 39  ? 18.58167 2.69846   16.73552  1.000 69.91962  ? 371 SER D N   1 
ATOM   2549 C CA  . SER D 2 39  ? 17.63526 3.55494   16.02804  1.000 75.25490  ? 371 SER D CA  1 
ATOM   2550 C C   . SER D 2 39  ? 17.63884 3.30257   14.52670  1.000 76.11557  ? 371 SER D C   1 
ATOM   2551 O O   . SER D 2 39  ? 16.59485 3.43867   13.87874  1.000 78.19831  ? 371 SER D O   1 
ATOM   2552 C CB  . SER D 2 39  ? 17.93870 5.02808   16.30395  1.000 71.07816  ? 371 SER D CB  1 
ATOM   2553 O OG  . SER D 2 39  ? 19.29569 5.33263   16.03428  1.000 68.44423  ? 371 SER D OG  1 
ATOM   2554 N N   . ALA D 2 40  ? 18.78566 2.94078   13.95879  1.000 75.58184  ? 372 ALA D N   1 
ATOM   2555 C CA  . ALA D 2 40  ? 18.90916 2.71156   12.52862  1.000 70.98695  ? 372 ALA D CA  1 
ATOM   2556 C C   . ALA D 2 40  ? 19.48172 1.32345   12.27895  1.000 71.44040  ? 372 ALA D C   1 
ATOM   2557 O O   . ALA D 2 40  ? 19.93232 0.63269   13.19762  1.000 68.20995  ? 372 ALA D O   1 
ATOM   2558 C CB  . ALA D 2 40  ? 19.78798 3.77941   11.86358  1.000 68.71265  ? 372 ALA D CB  1 
ATOM   2559 N N   . SER D 2 41  ? 19.45589 0.92076   11.01052  1.000 72.63130  ? 373 SER D N   1 
ATOM   2560 C CA  . SER D 2 41  ? 19.98674 -0.37099  10.58165  1.000 66.44434  ? 373 SER D CA  1 
ATOM   2561 C C   . SER D 2 41  ? 21.42946 -0.16504  10.13824  1.000 59.96032  ? 373 SER D C   1 
ATOM   2562 O O   . SER D 2 41  ? 21.69180 0.24533   9.00480   1.000 68.17711  ? 373 SER D O   1 
ATOM   2563 C CB  . SER D 2 41  ? 19.13349 -0.95499  9.46252   1.000 66.70992  ? 373 SER D CB  1 
ATOM   2564 O OG  . SER D 2 41  ? 19.05548 -0.05765  8.36861   1.000 78.07876  ? 373 SER D OG  1 
ATOM   2565 N N   . PHE D 2 42  ? 22.36922 -0.44955  11.03337  1.000 50.63806  ? 374 PHE D N   1 
ATOM   2566 C CA  . PHE D 2 42  ? 23.78617 -0.25524  10.76664  1.000 53.47907  ? 374 PHE D CA  1 
ATOM   2567 C C   . PHE D 2 42  ? 24.42940 -1.56065  10.32327  1.000 54.78944  ? 374 PHE D C   1 
ATOM   2568 O O   . PHE D 2 42  ? 24.07441 -2.63916  10.80754  1.000 56.70784  ? 374 PHE D O   1 
ATOM   2569 C CB  . PHE D 2 42  ? 24.51356 0.27321   12.00332  1.000 54.13975  ? 374 PHE D CB  1 
ATOM   2570 C CG  . PHE D 2 42  ? 23.92083 1.52818   12.56542  1.000 55.63789  ? 374 PHE D CG  1 
ATOM   2571 C CD1 . PHE D 2 42  ? 24.02110 2.72567   11.87804  1.000 50.45607  ? 374 PHE D CD1 1 
ATOM   2572 C CD2 . PHE D 2 42  ? 23.27028 1.51338   13.78592  1.000 51.68310  ? 374 PHE D CD2 1 
ATOM   2573 C CE1 . PHE D 2 42  ? 23.47871 3.88538   12.39760  1.000 56.73535  ? 374 PHE D CE1 1 
ATOM   2574 C CE2 . PHE D 2 42  ? 22.72569 2.66847   14.30816  1.000 55.93547  ? 374 PHE D CE2 1 
ATOM   2575 C CZ  . PHE D 2 42  ? 22.83164 3.85630   13.61554  1.000 54.69391  ? 374 PHE D CZ  1 
ATOM   2576 N N   . SER D 2 43  ? 25.38130 -1.45203  9.39838   1.000 52.25542  ? 375 SER D N   1 
ATOM   2577 C CA  . SER D 2 43  ? 26.20086 -2.58461  8.99609   1.000 51.47554  ? 375 SER D CA  1 
ATOM   2578 C C   . SER D 2 43  ? 27.54249 -2.62550  9.71193   1.000 52.85380  ? 375 SER D C   1 
ATOM   2579 O O   . SER D 2 43  ? 28.18255 -3.68295  9.73653   1.000 54.96001  ? 375 SER D O   1 
ATOM   2580 C CB  . SER D 2 43  ? 26.43427 -2.56016  7.47945   1.000 55.75310  ? 375 SER D CB  1 
ATOM   2581 O OG  . SER D 2 43  ? 27.03467 -1.34153  7.07398   1.000 53.42700  ? 375 SER D OG  1 
ATOM   2582 N N   . THR D 2 44  ? 27.97599 -1.50748  10.29191  1.000 48.75937  ? 376 THR D N   1 
ATOM   2583 C CA  . THR D 2 44  ? 29.21561 -1.44377  11.05276  1.000 46.02879  ? 376 THR D CA  1 
ATOM   2584 C C   . THR D 2 44  ? 28.98536 -0.58440  12.28615  1.000 51.11111  ? 376 THR D C   1 
ATOM   2585 O O   . THR D 2 44  ? 28.44616 0.52180   12.18287  1.000 53.18655  ? 376 THR D O   1 
ATOM   2586 C CB  . THR D 2 44  ? 30.36442 -0.87153  10.20961  1.000 49.57075  ? 376 THR D CB  1 
ATOM   2587 O OG1 . THR D 2 44  ? 30.69255 -1.78477  9.15462   1.000 50.19913  ? 376 THR D OG1 1 
ATOM   2588 C CG2 . THR D 2 44  ? 31.59949 -0.63569  11.06977  1.000 50.06287  ? 376 THR D CG2 1 
ATOM   2589 N N   . PHE D 2 45  ? 29.37795 -1.10201  13.44596  1.000 49.44883  ? 377 PHE D N   1 
ATOM   2590 C CA  . PHE D 2 45  ? 29.28243 -0.39063  14.71546  1.000 48.75511  ? 377 PHE D CA  1 
ATOM   2591 C C   . PHE D 2 45  ? 30.39156 -0.91201  15.62752  1.000 51.84086  ? 377 PHE D C   1 
ATOM   2592 O O   . PHE D 2 45  ? 30.15735 -1.52824  16.66503  1.000 55.56878  ? 377 PHE D O   1 
ATOM   2593 C CB  . PHE D 2 45  ? 27.90000 -0.56182  15.33991  1.000 49.29084  ? 377 PHE D CB  1 
ATOM   2594 C CG  . PHE D 2 45  ? 27.48808 0.57997   16.22460  1.000 51.66856  ? 377 PHE D CG  1 
ATOM   2595 C CD1 . PHE D 2 45  ? 28.06286 0.75183   17.47389  1.000 60.37891  ? 377 PHE D CD1 1 
ATOM   2596 C CD2 . PHE D 2 45  ? 26.51903 1.47782   15.80893  1.000 49.83171  ? 377 PHE D CD2 1 
ATOM   2597 C CE1 . PHE D 2 45  ? 27.68264 1.80148   18.28903  1.000 52.26260  ? 377 PHE D CE1 1 
ATOM   2598 C CE2 . PHE D 2 45  ? 26.13258 2.52765   16.61902  1.000 50.36347  ? 377 PHE D CE2 1 
ATOM   2599 C CZ  . PHE D 2 45  ? 26.71501 2.69019   17.86068  1.000 55.46509  ? 377 PHE D CZ  1 
ATOM   2600 N N   . LYS D 2 46  ? 31.63546 -0.66441  15.23251  1.000 48.51658  ? 378 LYS D N   1 
ATOM   2601 C CA  . LYS D 2 46  ? 32.80329 -1.19633  15.91931  1.000 47.86736  ? 378 LYS D CA  1 
ATOM   2602 C C   . LYS D 2 46  ? 33.38012 -0.12441  16.83470  1.000 53.25761  ? 378 LYS D C   1 
ATOM   2603 O O   . LYS D 2 46  ? 33.79318 0.94138   16.36505  1.000 51.18658  ? 378 LYS D O   1 
ATOM   2604 C CB  . LYS D 2 46  ? 33.84868 -1.66711  14.90972  1.000 45.82414  ? 378 LYS D CB  1 
ATOM   2605 C CG  . LYS D 2 46  ? 35.04335 -2.36993  15.52106  1.000 51.51941  ? 378 LYS D CG  1 
ATOM   2606 C CD  . LYS D 2 46  ? 35.88774 -3.03338  14.44257  1.000 56.38605  ? 378 LYS D CD  1 
ATOM   2607 C CE  . LYS D 2 46  ? 37.04079 -3.81791  15.04612  1.000 63.87931  ? 378 LYS D CE  1 
ATOM   2608 N NZ  . LYS D 2 46  ? 37.84515 -4.52786  14.01287  1.000 63.40730  ? 378 LYS D NZ  1 
ATOM   2609 N N   . CYS D 2 47  ? 33.40540 -0.40741  18.13434  1.000 54.80948  ? 379 CYS D N   1 
ATOM   2610 C CA  . CYS D 2 47  ? 33.96174 0.49708   19.13147  1.000 52.14485  ? 379 CYS D CA  1 
ATOM   2611 C C   . CYS D 2 47  ? 35.29930 -0.04416  19.61349  1.000 52.36542  ? 379 CYS D C   1 
ATOM   2612 O O   . CYS D 2 47  ? 35.40354 -1.22082  19.97415  1.000 59.61620  ? 379 CYS D O   1 
ATOM   2613 C CB  . CYS D 2 47  ? 33.00420 0.67160   20.30869  1.000 48.22311  ? 379 CYS D CB  1 
ATOM   2614 S SG  . CYS D 2 47  ? 31.45194 1.48724   19.88800  1.000 59.01621  ? 379 CYS D SG  1 
ATOM   2615 N N   . TYR D 2 48  ? 36.31535 0.81435   19.61759  1.000 49.21980  ? 380 TYR D N   1 
ATOM   2616 C CA  . TYR D 2 48  ? 37.67165 0.43400   19.99539  1.000 57.08037  ? 380 TYR D CA  1 
ATOM   2617 C C   . TYR D 2 48  ? 37.92344 0.88613   21.42929  1.000 62.92581  ? 380 TYR D C   1 
ATOM   2618 O O   . TYR D 2 48  ? 38.02069 2.08743   21.70197  1.000 66.97930  ? 380 TYR D O   1 
ATOM   2619 C CB  . TYR D 2 48  ? 38.68981 1.04119   19.03296  1.000 51.74361  ? 380 TYR D CB  1 
ATOM   2620 C CG  . TYR D 2 48  ? 38.52855 0.55911   17.60784  1.000 58.63599  ? 380 TYR D CG  1 
ATOM   2621 C CD1 . TYR D 2 48  ? 37.64157 1.18188   16.73794  1.000 53.54857  ? 380 TYR D CD1 1 
ATOM   2622 C CD2 . TYR D 2 48  ? 39.25777 -0.52318  17.13414  1.000 59.08943  ? 380 TYR D CD2 1 
ATOM   2623 C CE1 . TYR D 2 48  ? 37.48859 0.74162   15.43928  1.000 51.85663  ? 380 TYR D CE1 1 
ATOM   2624 C CE2 . TYR D 2 48  ? 39.11102 -0.97042  15.83447  1.000 54.57621  ? 380 TYR D CE2 1 
ATOM   2625 C CZ  . TYR D 2 48  ? 38.22550 -0.33474  14.99288  1.000 54.61332  ? 380 TYR D CZ  1 
ATOM   2626 O OH  . TYR D 2 48  ? 38.07821 -0.77629  13.69887  1.000 56.51580  ? 380 TYR D OH  1 
ATOM   2627 N N   . GLY D 2 49  ? 38.03189 -0.07806  22.34050  1.000 63.99219  ? 381 GLY D N   1 
ATOM   2628 C CA  . GLY D 2 49  ? 38.21521 0.21916   23.74532  1.000 72.32905  ? 381 GLY D CA  1 
ATOM   2629 C C   . GLY D 2 49  ? 36.96691 0.65421   24.47641  1.000 68.80262  ? 381 GLY D C   1 
ATOM   2630 O O   . GLY D 2 49  ? 37.06999 1.14417   25.60636  1.000 76.94938  ? 381 GLY D O   1 
ATOM   2631 N N   . VAL D 2 50  ? 35.79117 0.50404   23.86702  1.000 69.01251  ? 382 VAL D N   1 
ATOM   2632 C CA  . VAL D 2 50  ? 34.53590 0.90664   24.49192  1.000 68.11238  ? 382 VAL D CA  1 
ATOM   2633 C C   . VAL D 2 50  ? 33.51405 -0.21151  24.33266  1.000 72.62076  ? 382 VAL D C   1 
ATOM   2634 O O   . VAL D 2 50  ? 33.87149 -1.36199  24.05660  1.000 73.20583  ? 382 VAL D O   1 
ATOM   2635 C CB  . VAL D 2 50  ? 33.99842 2.22299   23.89449  1.000 70.58375  ? 382 VAL D CB  1 
ATOM   2636 C CG1 . VAL D 2 50  ? 33.60446 3.18620   25.00304  1.000 75.77232  ? 382 VAL D CG1 1 
ATOM   2637 C CG2 . VAL D 2 50  ? 35.01486 2.86375   22.95022  1.000 65.53739  ? 382 VAL D CG2 1 
ATOM   2638 N N   . SER D 2 51  ? 32.23210 0.12299   24.50995  1.000 72.18501  ? 383 SER D N   1 
ATOM   2639 C CA  . SER D 2 51  ? 31.13274 -0.80561  24.28905  1.000 70.17027  ? 383 SER D CA  1 
ATOM   2640 C C   . SER D 2 51  ? 29.86043 0.00296   24.11807  1.000 73.00700  ? 383 SER D C   1 
ATOM   2641 O O   . SER D 2 51  ? 29.65052 0.96044   24.87513  1.000 69.46973  ? 383 SER D O   1 
ATOM   2642 C CB  . SER D 2 51  ? 30.97851 -1.79329  25.44942  1.000 78.13504  ? 383 SER D CB  1 
ATOM   2643 O OG  . SER D 2 51  ? 29.85239 -2.63086  25.25101  1.000 78.24963  ? 383 SER D OG  1 
ATOM   2644 N N   . PRO D 2 52  ? 29.00024 -0.33718  23.15223  1.000 77.23019  ? 384 PRO D N   1 
ATOM   2645 C CA  . PRO D 2 52  ? 27.78464 0.47121   22.94324  1.000 76.28824  ? 384 PRO D CA  1 
ATOM   2646 C C   . PRO D 2 52  ? 26.89745 0.56139   24.17232  1.000 76.49709  ? 384 PRO D C   1 
ATOM   2647 O O   . PRO D 2 52  ? 26.33663 1.62892   24.44816  1.000 79.37947  ? 384 PRO D O   1 
ATOM   2648 C CB  . PRO D 2 52  ? 27.08257 -0.25139  21.78386  1.000 68.99562  ? 384 PRO D CB  1 
ATOM   2649 C CG  . PRO D 2 52  ? 28.17440 -0.98775  21.07843  1.000 71.22924  ? 384 PRO D CG  1 
ATOM   2650 C CD  . PRO D 2 52  ? 29.13705 -1.40738  22.14996  1.000 70.07290  ? 384 PRO D CD  1 
ATOM   2651 N N   . THR D 2 53  ? 26.75528 -0.53057  24.92453  1.000 77.98220  ? 385 THR D N   1 
ATOM   2652 C CA  . THR D 2 53  ? 25.94278 -0.49003  26.13509  1.000 77.13182  ? 385 THR D CA  1 
ATOM   2653 C C   . THR D 2 53  ? 26.68747 0.17924   27.28437  1.000 76.09011  ? 385 THR D C   1 
ATOM   2654 O O   . THR D 2 53  ? 26.11670 1.01653   27.99218  1.000 72.85221  ? 385 THR D O   1 
ATOM   2655 C CB  . THR D 2 53  ? 25.51157 -1.90348  26.52891  1.000 83.25014  ? 385 THR D CB  1 
ATOM   2656 O OG1 . THR D 2 53  ? 26.66812 -2.73978  26.66319  1.000 88.16293  ? 385 THR D OG1 1 
ATOM   2657 C CG2 . THR D 2 53  ? 24.58470 -2.49082  25.47352  1.000 76.57806  ? 385 THR D CG2 1 
ATOM   2658 N N   . LYS D 2 54  ? 27.96137 -0.16981  27.48072  1.000 75.56743  ? 386 LYS D N   1 
ATOM   2659 C CA  . LYS D 2 54  ? 28.76413 0.45260   28.52686  1.000 68.79817  ? 386 LYS D CA  1 
ATOM   2660 C C   . LYS D 2 54  ? 29.07394 1.91670   28.24450  1.000 70.90215  ? 386 LYS D C   1 
ATOM   2661 O O   . LYS D 2 54  ? 29.56199 2.61216   29.14260  1.000 62.70277  ? 386 LYS D O   1 
ATOM   2662 C CB  . LYS D 2 54  ? 30.07121 -0.31625  28.71652  1.000 65.65216  ? 386 LYS D CB  1 
ATOM   2663 C CG  . LYS D 2 54  ? 29.89842 -1.71274  29.28133  1.000 70.05780  ? 386 LYS D CG  1 
ATOM   2664 C CD  . LYS D 2 54  ? 31.24373 -2.30689  29.66555  1.000 73.41058  ? 386 LYS D CD  1 
ATOM   2665 C CE  . LYS D 2 54  ? 31.97821 -1.41048  30.65462  1.000 67.96450  ? 386 LYS D CE  1 
ATOM   2666 N NZ  . LYS D 2 54  ? 33.33352 -1.93080  30.98960  1.000 68.12322  ? 386 LYS D NZ  1 
ATOM   2667 N N   . LEU D 2 55  ? 28.81048 2.39627   27.02625  1.000 72.33442  ? 387 LEU D N   1 
ATOM   2668 C CA  . LEU D 2 55  ? 29.04327 3.80222   26.71474  1.000 67.90230  ? 387 LEU D CA  1 
ATOM   2669 C C   . LEU D 2 55  ? 28.13551 4.71588   27.52641  1.000 65.42885  ? 387 LEU D C   1 
ATOM   2670 O O   . LEU D 2 55  ? 28.50489 5.86016   27.81612  1.000 54.26661  ? 387 LEU D O   1 
ATOM   2671 C CB  . LEU D 2 55  ? 28.84171 4.04423   25.21969  1.000 68.48608  ? 387 LEU D CB  1 
ATOM   2672 C CG  . LEU D 2 55  ? 30.10728 4.22937   24.38290  1.000 67.69421  ? 387 LEU D CG  1 
ATOM   2673 C CD1 . LEU D 2 55  ? 29.77159 4.23136   22.90220  1.000 59.20973  ? 387 LEU D CD1 1 
ATOM   2674 C CD2 . LEU D 2 55  ? 30.80681 5.51964   24.77910  1.000 66.02060  ? 387 LEU D CD2 1 
ATOM   2675 N N   . ASN D 2 56  ? 26.95046 4.23295   27.90253  1.000 68.00226  ? 388 ASN D N   1 
ATOM   2676 C CA  . ASN D 2 56  ? 26.02776 5.01710   28.71313  1.000 66.22886  ? 388 ASN D CA  1 
ATOM   2677 C C   . ASN D 2 56  ? 26.49994 5.19193   30.14807  1.000 61.50140  ? 388 ASN D C   1 
ATOM   2678 O O   . ASN D 2 56  ? 25.84805 5.91561   30.90778  1.000 62.59279  ? 388 ASN D O   1 
ATOM   2679 C CB  . ASN D 2 56  ? 24.64049 4.37301   28.69575  1.000 66.08092  ? 388 ASN D CB  1 
ATOM   2680 C CG  . ASN D 2 56  ? 23.83889 4.75705   27.46978  1.000 62.23776  ? 388 ASN D CG  1 
ATOM   2681 O OD1 . ASN D 2 56  ? 24.31624 5.49881   26.61171  1.000 58.54714  ? 388 ASN D OD1 1 
ATOM   2682 N ND2 . ASN D 2 56  ? 22.61326 4.25327   27.38024  1.000 67.48963  ? 388 ASN D ND2 1 
ATOM   2683 N N   . ASP D 2 57  ? 27.60601 4.56105   30.53495  1.000 63.47351  ? 389 ASP D N   1 
ATOM   2684 C CA  . ASP D 2 57  ? 28.14457 4.67753   31.88173  1.000 64.63582  ? 389 ASP D CA  1 
ATOM   2685 C C   . ASP D 2 57  ? 29.35752 5.59298   31.95743  1.000 61.87004  ? 389 ASP D C   1 
ATOM   2686 O O   . ASP D 2 57  ? 29.87419 5.82366   33.05515  1.000 63.37998  ? 389 ASP D O   1 
ATOM   2687 C CB  . ASP D 2 57  ? 28.51936 3.29379   32.42335  1.000 64.50541  ? 389 ASP D CB  1 
ATOM   2688 C CG  . ASP D 2 57  ? 27.43579 2.25976   32.18715  1.000 70.54777  ? 389 ASP D CG  1 
ATOM   2689 O OD1 . ASP D 2 57  ? 26.28051 2.65342   31.91904  1.000 76.04786  ? 389 ASP D OD1 1 
ATOM   2690 O OD2 . ASP D 2 57  ? 27.74002 1.05051   32.27293  1.000 66.25387  ? 389 ASP D OD2 1 
ATOM   2691 N N   . LEU D 2 58  ? 29.82181 6.12111   30.83004  1.000 60.29776  ? 390 LEU D N   1 
ATOM   2692 C CA  . LEU D 2 58  ? 31.04340 6.90838   30.79009  1.000 56.09790  ? 390 LEU D CA  1 
ATOM   2693 C C   . LEU D 2 58  ? 30.74837 8.36148   30.43921  1.000 53.78765  ? 390 LEU D C   1 
ATOM   2694 O O   . LEU D 2 58  ? 29.67204 8.70518   29.94090  1.000 50.48443  ? 390 LEU D O   1 
ATOM   2695 C CB  . LEU D 2 58  ? 32.04081 6.31912   29.78499  1.000 51.97854  ? 390 LEU D CB  1 
ATOM   2696 C CG  . LEU D 2 58  ? 32.52743 4.90024   30.09259  1.000 56.67245  ? 390 LEU D CG  1 
ATOM   2697 C CD1 . LEU D 2 58  ? 33.60038 4.46805   29.10769  1.000 55.68923  ? 390 LEU D CD1 1 
ATOM   2698 C CD2 . LEU D 2 58  ? 33.04106 4.80800   31.51999  1.000 57.56317  ? 390 LEU D CD2 1 
ATOM   2699 N N   . CYS D 2 59  ? 31.73446 9.21308   30.71327  1.000 53.84111  ? 391 CYS D N   1 
ATOM   2700 C CA  . CYS D 2 59  ? 31.68166 10.63143  30.39794  1.000 46.86123  ? 391 CYS D CA  1 
ATOM   2701 C C   . CYS D 2 59  ? 32.93583 11.01004  29.62578  1.000 48.69259  ? 391 CYS D C   1 
ATOM   2702 O O   . CYS D 2 59  ? 33.97233 10.34916  29.72562  1.000 48.74721  ? 391 CYS D O   1 
ATOM   2703 C CB  . CYS D 2 59  ? 31.57624 11.49937  31.66128  1.000 52.81567  ? 391 CYS D CB  1 
ATOM   2704 S SG  . CYS D 2 59  ? 30.07902 11.29367  32.65140  1.000 46.58867  ? 391 CYS D SG  1 
ATOM   2705 N N   . PHE D 2 60  ? 32.83722 12.08913  28.85391  1.000 46.83024  ? 392 PHE D N   1 
ATOM   2706 C CA  . PHE D 2 60  ? 33.96328 12.56097  28.06345  1.000 48.30219  ? 392 PHE D CA  1 
ATOM   2707 C C   . PHE D 2 60  ? 33.94692 14.08083  28.00598  1.000 47.67092  ? 392 PHE D C   1 
ATOM   2708 O O   . PHE D 2 60  ? 32.89625 14.71362  28.15102  1.000 43.72341  ? 392 PHE D O   1 
ATOM   2709 C CB  . PHE D 2 60  ? 33.94325 11.96705  26.64884  1.000 40.42132  ? 392 PHE D CB  1 
ATOM   2710 C CG  . PHE D 2 60  ? 34.07379 10.47136  26.62460  1.000 43.58565  ? 392 PHE D CG  1 
ATOM   2711 C CD1 . PHE D 2 60  ? 35.30151 9.86844   26.84197  1.000 41.02208  ? 392 PHE D CD1 1 
ATOM   2712 C CD2 . PHE D 2 60  ? 32.96863 9.66772   26.39940  1.000 42.21922  ? 392 PHE D CD2 1 
ATOM   2713 C CE1 . PHE D 2 60  ? 35.42831 8.49084   26.83123  1.000 40.50009  ? 392 PHE D CE1 1 
ATOM   2714 C CE2 . PHE D 2 60  ? 33.08876 8.28945   26.38429  1.000 45.53615  ? 392 PHE D CE2 1 
ATOM   2715 C CZ  . PHE D 2 60  ? 34.32169 7.70090   26.60124  1.000 44.22771  ? 392 PHE D CZ  1 
ATOM   2716 N N   . THR D 2 61  ? 35.13549 14.65934  27.81132  1.000 43.25147  ? 393 THR D N   1 
ATOM   2717 C CA  . THR D 2 61  ? 35.25097 16.11089  27.70831  1.000 45.84560  ? 393 THR D CA  1 
ATOM   2718 C C   . THR D 2 61  ? 34.43294 16.63424  26.53729  1.000 48.65257  ? 393 THR D C   1 
ATOM   2719 O O   . THR D 2 61  ? 33.61357 17.54720  26.69170  1.000 45.62045  ? 393 THR D O   1 
ATOM   2720 C CB  . THR D 2 61  ? 36.71901 16.51277  27.55661  1.000 48.98570  ? 393 THR D CB  1 
ATOM   2721 O OG1 . THR D 2 61  ? 37.49996 15.88157  28.57869  1.000 54.30051  ? 393 THR D OG1 1 
ATOM   2722 C CG2 . THR D 2 61  ? 36.87162 18.02232  27.67214  1.000 50.62382  ? 393 THR D CG2 1 
ATOM   2723 N N   . ASN D 2 62  ? 34.65397 16.06987  25.35325  1.000 45.71472  ? 394 ASN D N   1 
ATOM   2724 C CA  . ASN D 2 62  ? 33.82118 16.33552  24.19200  1.000 44.98085  ? 394 ASN D CA  1 
ATOM   2725 C C   . ASN D 2 62  ? 33.69420 15.04760  23.39362  1.000 42.42558  ? 394 ASN D C   1 
ATOM   2726 O O   . ASN D 2 62  ? 34.41378 14.07224  23.62438  1.000 39.23841  ? 394 ASN D O   1 
ATOM   2727 C CB  . ASN D 2 62  ? 34.39617 17.45340  23.31383  1.000 43.99550  ? 394 ASN D CB  1 
ATOM   2728 C CG  . ASN D 2 62  ? 34.57175 18.75718  24.06343  1.000 44.06300  ? 394 ASN D CG  1 
ATOM   2729 O OD1 . ASN D 2 62  ? 33.65785 19.57673  24.12798  1.000 43.01820  ? 394 ASN D OD1 1 
ATOM   2730 N ND2 . ASN D 2 62  ? 35.75504 18.95927  24.62855  1.000 48.59850  ? 394 ASN D ND2 1 
ATOM   2731 N N   . VAL D 2 63  ? 32.75759 15.04989  22.45205  1.000 46.46548  ? 395 VAL D N   1 
ATOM   2732 C CA  . VAL D 2 63  ? 32.64398 13.99129  21.45855  1.000 46.94724  ? 395 VAL D CA  1 
ATOM   2733 C C   . VAL D 2 63  ? 32.65556 14.64222  20.08547  1.000 45.15664  ? 395 VAL D C   1 
ATOM   2734 O O   . VAL D 2 63  ? 31.94631 15.62825  19.85597  1.000 44.79106  ? 395 VAL D O   1 
ATOM   2735 C CB  . VAL D 2 63  ? 31.37356 13.14173  21.65092  1.000 45.65898  ? 395 VAL D CB  1 
ATOM   2736 C CG1 . VAL D 2 63  ? 31.29874 12.06320  20.58102  1.000 45.15082  ? 395 VAL D CG1 1 
ATOM   2737 C CG2 . VAL D 2 63  ? 31.35899 12.51808  23.03889  1.000 38.70810  ? 395 VAL D CG2 1 
ATOM   2738 N N   . TYR D 2 64  ? 33.47038 14.10511  19.18387  1.000 47.45418  ? 396 TYR D N   1 
ATOM   2739 C CA  . TYR D 2 64  ? 33.57145 14.59944  17.81983  1.000 44.58118  ? 396 TYR D CA  1 
ATOM   2740 C C   . TYR D 2 64  ? 32.97482 13.58022  16.86131  1.000 45.63343  ? 396 TYR D C   1 
ATOM   2741 O O   . TYR D 2 64  ? 33.18375 12.37248  17.01402  1.000 42.73202  ? 396 TYR D O   1 
ATOM   2742 C CB  . TYR D 2 64  ? 35.02637 14.89089  17.44835  1.000 41.94845  ? 396 TYR D CB  1 
ATOM   2743 C CG  . TYR D 2 64  ? 35.66891 15.92047  18.34559  1.000 46.27349  ? 396 TYR D CG  1 
ATOM   2744 C CD1 . TYR D 2 64  ? 35.57040 17.27492  18.05984  1.000 49.24956  ? 396 TYR D CD1 1 
ATOM   2745 C CD2 . TYR D 2 64  ? 36.36234 15.53926  19.48706  1.000 44.52704  ? 396 TYR D CD2 1 
ATOM   2746 C CE1 . TYR D 2 64  ? 36.15166 18.22017  18.88038  1.000 51.47329  ? 396 TYR D CE1 1 
ATOM   2747 C CE2 . TYR D 2 64  ? 36.94783 16.47634  20.31181  1.000 47.35697  ? 396 TYR D CE2 1 
ATOM   2748 C CZ  . TYR D 2 64  ? 36.83898 17.81565  20.00547  1.000 50.41429  ? 396 TYR D CZ  1 
ATOM   2749 O OH  . TYR D 2 64  ? 37.42066 18.75402  20.82714  1.000 55.45071  ? 396 TYR D OH  1 
ATOM   2750 N N   . ALA D 2 65  ? 32.22770 14.07536  15.87732  1.000 45.07345  ? 397 ALA D N   1 
ATOM   2751 C CA  . ALA D 2 65  ? 31.51933 13.23822  14.91577  1.000 41.07583  ? 397 ALA D CA  1 
ATOM   2752 C C   . ALA D 2 65  ? 32.05556 13.53589  13.52256  1.000 41.77182  ? 397 ALA D C   1 
ATOM   2753 O O   . ALA D 2 65  ? 31.75916 14.59021  12.94991  1.000 45.53789  ? 397 ALA D O   1 
ATOM   2754 C CB  . ALA D 2 65  ? 30.01229 13.47868  14.98586  1.000 45.97411  ? 397 ALA D CB  1 
ATOM   2755 N N   . ASP D 2 66  ? 32.84521 12.61073  12.98486  1.000 41.47511  ? 398 ASP D N   1 
ATOM   2756 C CA  . ASP D 2 66  ? 33.34897 12.70560  11.62143  1.000 41.96569  ? 398 ASP D CA  1 
ATOM   2757 C C   . ASP D 2 66  ? 32.42294 11.92193  10.69921  1.000 42.67168  ? 398 ASP D C   1 
ATOM   2758 O O   . ASP D 2 66  ? 32.18796 10.72938  10.91999  1.000 43.61212  ? 398 ASP D O   1 
ATOM   2759 C CB  . ASP D 2 66  ? 34.77839 12.17259  11.53521  1.000 38.28785  ? 398 ASP D CB  1 
ATOM   2760 C CG  . ASP D 2 66  ? 35.75145 12.99305  12.35097  1.000 38.78265  ? 398 ASP D CG  1 
ATOM   2761 O OD1 . ASP D 2 66  ? 35.45375 14.17893  12.59910  1.000 41.14672  ? 398 ASP D OD1 1 
ATOM   2762 O OD2 . ASP D 2 66  ? 36.81070 12.45788  12.74340  1.000 41.79588  ? 398 ASP D OD2 1 
ATOM   2763 N N   . SER D 2 67  ? 31.89827 12.58845  9.67086   1.000 42.22336  ? 399 SER D N   1 
ATOM   2764 C CA  . SER D 2 67  ? 30.92534 11.98574  8.77089   1.000 41.97764  ? 399 SER D CA  1 
ATOM   2765 C C   . SER D 2 67  ? 31.35444 12.17385  7.32314   1.000 43.42481  ? 399 SER D C   1 
ATOM   2766 O O   . SER D 2 67  ? 31.84469 13.24127  6.94184   1.000 44.84891  ? 399 SER D O   1 
ATOM   2767 C CB  . SER D 2 67  ? 29.52643 12.57922  8.98503   1.000 41.35413  ? 399 SER D CB  1 
ATOM   2768 O OG  . SER D 2 67  ? 29.54347 13.99208  8.87899   1.000 41.09196  ? 399 SER D OG  1 
ATOM   2769 N N   . PHE D 2 68  ? 31.15969 11.13106  6.52339   1.000 45.39797  ? 400 PHE D N   1 
ATOM   2770 C CA  . PHE D 2 68  ? 31.51231 11.13620  5.10690   1.000 42.04667  ? 400 PHE D CA  1 
ATOM   2771 C C   . PHE D 2 68  ? 30.88308 9.90559   4.46385   1.000 41.70971  ? 400 PHE D C   1 
ATOM   2772 O O   . PHE D 2 68  ? 30.23719 9.09127   5.13156   1.000 37.54416  ? 400 PHE D O   1 
ATOM   2773 C CB  . PHE D 2 68  ? 33.02953 11.16415  4.90334   1.000 41.88419  ? 400 PHE D CB  1 
ATOM   2774 C CG  . PHE D 2 68  ? 33.76828 10.12856  5.70111   1.000 40.01218  ? 400 PHE D CG  1 
ATOM   2775 C CD1 . PHE D 2 68  ? 33.94629 8.84875   5.20505   1.000 37.43461  ? 400 PHE D CD1 1 
ATOM   2776 C CD2 . PHE D 2 68  ? 34.28688 10.43628  6.94809   1.000 43.76046  ? 400 PHE D CD2 1 
ATOM   2777 C CE1 . PHE D 2 68  ? 34.62529 7.89445   5.93598   1.000 40.39468  ? 400 PHE D CE1 1 
ATOM   2778 C CE2 . PHE D 2 68  ? 34.96631 9.48555   7.68535   1.000 43.16723  ? 400 PHE D CE2 1 
ATOM   2779 C CZ  . PHE D 2 68  ? 35.13503 8.21258   7.17876   1.000 44.62017  ? 400 PHE D CZ  1 
ATOM   2780 N N   . VAL D 2 69  ? 31.07945 9.77782   3.15293   1.000 47.57851  ? 401 VAL D N   1 
ATOM   2781 C CA  . VAL D 2 69  ? 30.55372 8.66481   2.37353   1.000 35.80732  ? 401 VAL D CA  1 
ATOM   2782 C C   . VAL D 2 69  ? 31.69994 8.03137   1.59919   1.000 41.74413  ? 401 VAL D C   1 
ATOM   2783 O O   . VAL D 2 69  ? 32.55612 8.73509   1.05229   1.000 42.45385  ? 401 VAL D O   1 
ATOM   2784 C CB  . VAL D 2 69  ? 29.42730 9.12199   1.42210   1.000 42.24856  ? 401 VAL D CB  1 
ATOM   2785 C CG1 . VAL D 2 69  ? 29.10866 8.04612   0.39085   1.000 45.51561  ? 401 VAL D CG1 1 
ATOM   2786 C CG2 . VAL D 2 69  ? 28.18197 9.47325   2.21453   1.000 38.81732  ? 401 VAL D CG2 1 
ATOM   2787 N N   . ILE D 2 70  ? 31.72791 6.70001   1.57729   1.000 39.12914  ? 402 ILE D N   1 
ATOM   2788 C CA  . ILE D 2 70  ? 32.68997 5.92233   0.81423   1.000 41.22698  ? 402 ILE D CA  1 
ATOM   2789 C C   . ILE D 2 70  ? 31.97512 4.70316   0.24290   1.000 44.02935  ? 402 ILE D C   1 
ATOM   2790 O O   . ILE D 2 70  ? 30.76292 4.53425   0.40269   1.000 41.34930  ? 402 ILE D O   1 
ATOM   2791 C CB  . ILE D 2 70  ? 33.90327 5.48871   1.66358   1.000 37.10477  ? 402 ILE D CB  1 
ATOM   2792 C CG1 . ILE D 2 70  ? 33.44062 4.91463   3.00535   1.000 40.09451  ? 402 ILE D CG1 1 
ATOM   2793 C CG2 . ILE D 2 70  ? 34.86908 6.64403   1.85725   1.000 35.02863  ? 402 ILE D CG2 1 
ATOM   2794 C CD1 . ILE D 2 70  ? 34.57390 4.41527   3.88012   1.000 38.67654  ? 402 ILE D CD1 1 
ATOM   2795 N N   . ARG D 2 71  ? 32.73937 3.84935   -0.43197  1.000 41.95963  ? 403 ARG D N   1 
ATOM   2796 C CA  . ARG D 2 71  ? 32.22025 2.57596   -0.90548  1.000 42.50228  ? 403 ARG D CA  1 
ATOM   2797 C C   . ARG D 2 71  ? 32.19744 1.56009   0.22964   1.000 41.98557  ? 403 ARG D C   1 
ATOM   2798 O O   . ARG D 2 71  ? 32.98802 1.63550   1.17368   1.000 44.16853  ? 403 ARG D O   1 
ATOM   2799 C CB  . ARG D 2 71  ? 33.06678 2.04428   -2.06101  1.000 38.43771  ? 403 ARG D CB  1 
ATOM   2800 C CG  . ARG D 2 71  ? 32.83876 2.74963   -3.38385  1.000 39.55141  ? 403 ARG D CG  1 
ATOM   2801 C CD  . ARG D 2 71  ? 34.03250 2.56197   -4.30325  1.000 41.43218  ? 403 ARG D CD  1 
ATOM   2802 N NE  . ARG D 2 71  ? 34.60748 1.22758   -4.18634  1.000 39.09997  ? 403 ARG D NE  1 
ATOM   2803 C CZ  . ARG D 2 71  ? 35.71153 0.83056   -4.80400  1.000 42.10348  ? 403 ARG D CZ  1 
ATOM   2804 N NH1 . ARG D 2 71  ? 36.37777 1.63598   -5.61616  1.000 44.19251  ? 403 ARG D NH1 1 
ATOM   2805 N NH2 . ARG D 2 71  ? 36.15928 -0.40538  -4.60208  1.000 38.44797  ? 403 ARG D NH2 1 
ATOM   2806 N N   . GLY D 2 72  ? 31.27778 0.59791   0.12427   1.000 46.14727  ? 404 GLY D N   1 
ATOM   2807 C CA  . GLY D 2 72  ? 31.13243 -0.40028  1.17092   1.000 41.73298  ? 404 GLY D CA  1 
ATOM   2808 C C   . GLY D 2 72  ? 32.38170 -1.22695  1.40044   1.000 44.22399  ? 404 GLY D C   1 
ATOM   2809 O O   . GLY D 2 72  ? 32.66474 -1.62861  2.53353   1.000 44.59794  ? 404 GLY D O   1 
ATOM   2810 N N   . ASP D 2 73  ? 33.14347 -1.49491  0.34120   1.000 41.61967  ? 405 ASP D N   1 
ATOM   2811 C CA  . ASP D 2 73  ? 34.39111 -2.23617  0.47507   1.000 44.56256  ? 405 ASP D CA  1 
ATOM   2812 C C   . ASP D 2 73  ? 35.51816 -1.38849  1.04821   1.000 42.04161  ? 405 ASP D C   1 
ATOM   2813 O O   . ASP D 2 73  ? 36.61770 -1.90934  1.26735   1.000 40.68277  ? 405 ASP D O   1 
ATOM   2814 C CB  . ASP D 2 73  ? 34.81055 -2.82702  -0.87996  1.000 47.13157  ? 405 ASP D CB  1 
ATOM   2815 C CG  . ASP D 2 73  ? 35.01998 -1.76778  -1.95638  1.000 49.61135  ? 405 ASP D CG  1 
ATOM   2816 O OD1 . ASP D 2 73  ? 34.89317 -0.55997  -1.66447  1.000 51.43722  ? 405 ASP D OD1 1 
ATOM   2817 O OD2 . ASP D 2 73  ? 35.31220 -2.15210  -3.11017  1.000 51.36396  ? 405 ASP D OD2 1 
ATOM   2818 N N   . GLU D 2 74  ? 35.27234 -0.10423  1.29157   1.000 38.43050  ? 406 GLU D N   1 
ATOM   2819 C CA  . GLU D 2 74  ? 36.25204 0.78392   1.89630   1.000 42.44053  ? 406 GLU D CA  1 
ATOM   2820 C C   . GLU D 2 74  ? 35.96187 1.07027   3.36564   1.000 46.01388  ? 406 GLU D C   1 
ATOM   2821 O O   . GLU D 2 74  ? 36.76590 1.74049   4.02309   1.000 47.73982  ? 406 GLU D O   1 
ATOM   2822 C CB  . GLU D 2 74  ? 36.32053 2.09296   1.10411   1.000 40.37921  ? 406 GLU D CB  1 
ATOM   2823 C CG  . GLU D 2 74  ? 36.81909 1.90542   -0.32588  1.000 39.00687  ? 406 GLU D CG  1 
ATOM   2824 C CD  . GLU D 2 74  ? 36.53644 3.09989   -1.21587  1.000 37.01978  ? 406 GLU D CD  1 
ATOM   2825 O OE1 . GLU D 2 74  ? 35.56842 3.83848   -0.93755  1.000 35.10707  ? 406 GLU D OE1 1 
ATOM   2826 O OE2 . GLU D 2 74  ? 37.28437 3.29910   -2.19763  1.000 45.18898  ? 406 GLU D OE2 1 
ATOM   2827 N N   . VAL D 2 75  ? 34.84019 0.57210   3.89495   1.000 36.96615  ? 407 VAL D N   1 
ATOM   2828 C CA  . VAL D 2 75  ? 34.50320 0.80298   5.29762   1.000 43.36353  ? 407 VAL D CA  1 
ATOM   2829 C C   . VAL D 2 75  ? 35.52633 0.14085   6.21383   1.000 40.17090  ? 407 VAL D C   1 
ATOM   2830 O O   . VAL D 2 75  ? 35.86727 0.67771   7.27487   1.000 46.91445  ? 407 VAL D O   1 
ATOM   2831 C CB  . VAL D 2 75  ? 33.07331 0.30894   5.58844   1.000 43.41423  ? 407 VAL D CB  1 
ATOM   2832 C CG1 . VAL D 2 75  ? 32.73529 0.46295   7.06512   1.000 41.30921  ? 407 VAL D CG1 1 
ATOM   2833 C CG2 . VAL D 2 75  ? 32.07065 1.05976   4.72725   1.000 44.79251  ? 407 VAL D CG2 1 
ATOM   2834 N N   . ARG D 2 76  ? 36.04252 -1.02555  5.81581   1.000 41.23444  ? 408 ARG D N   1 
ATOM   2835 C CA  . ARG D 2 76  ? 37.05723 -1.70794  6.61122   1.000 45.83807  ? 408 ARG D CA  1 
ATOM   2836 C C   . ARG D 2 76  ? 38.32102 -0.87375  6.77484   1.000 46.07905  ? 408 ARG D C   1 
ATOM   2837 O O   . ARG D 2 76  ? 39.09566 -1.11858  7.70614   1.000 49.46999  ? 408 ARG D O   1 
ATOM   2838 C CB  . ARG D 2 76  ? 37.39870 -3.06236  5.97971   1.000 47.01696  ? 408 ARG D CB  1 
ATOM   2839 C CG  . ARG D 2 76  ? 37.99525 -2.98372  4.57259   1.000 52.20688  ? 408 ARG D CG  1 
ATOM   2840 C CD  . ARG D 2 76  ? 39.52033 -3.05918  4.59138   1.000 55.62778  ? 408 ARG D CD  1 
ATOM   2841 N NE  . ARG D 2 76  ? 40.09734 -2.78280  3.28045   1.000 63.60925  ? 408 ARG D NE  1 
ATOM   2842 C CZ  . ARG D 2 76  ? 41.39550 -2.64504  3.04343   1.000 64.46754  ? 408 ARG D CZ  1 
ATOM   2843 N NH1 . ARG D 2 76  ? 42.29078 -2.75092  4.01207   1.000 63.42495  ? 408 ARG D NH1 1 
ATOM   2844 N NH2 . ARG D 2 76  ? 41.80534 -2.39092  1.80337   1.000 66.40148  ? 408 ARG D NH2 1 
ATOM   2845 N N   . GLN D 2 77  ? 38.55148 0.09835   5.89139   1.000 43.39337  ? 409 GLN D N   1 
ATOM   2846 C CA  . GLN D 2 77  ? 39.72650 0.94993   6.00599   1.000 47.45069  ? 409 GLN D CA  1 
ATOM   2847 C C   . GLN D 2 77  ? 39.57912 2.00123   7.09504   1.000 46.33619  ? 409 GLN D C   1 
ATOM   2848 O O   . GLN D 2 77  ? 40.59108 2.53217   7.56632   1.000 43.10638  ? 409 GLN D O   1 
ATOM   2849 C CB  . GLN D 2 77  ? 40.01943 1.62874   4.66843   1.000 44.43019  ? 409 GLN D CB  1 
ATOM   2850 C CG  . GLN D 2 77  ? 40.24695 0.65623   3.52734   1.000 48.83390  ? 409 GLN D CG  1 
ATOM   2851 C CD  . GLN D 2 77  ? 40.72106 1.34377   2.26591   1.000 47.34885  ? 409 GLN D CD  1 
ATOM   2852 O OE1 . GLN D 2 77  ? 41.28354 2.43721   2.31526   1.000 46.00182  ? 409 GLN D OE1 1 
ATOM   2853 N NE2 . GLN D 2 77  ? 40.49228 0.70672   1.12424   1.000 53.09199  ? 409 GLN D NE2 1 
ATOM   2854 N N   . ILE D 2 78  ? 38.35011 2.31261   7.50276   1.000 43.61152  ? 410 ILE D N   1 
ATOM   2855 C CA  . ILE D 2 78  ? 38.11863 3.22976   8.61161   1.000 42.58214  ? 410 ILE D CA  1 
ATOM   2856 C C   . ILE D 2 78  ? 38.36860 2.46907   9.90748   1.000 47.51460  ? 410 ILE D C   1 
ATOM   2857 O O   . ILE D 2 78  ? 37.43397 2.15540   10.65343  1.000 46.80006  ? 410 ILE D O   1 
ATOM   2858 C CB  . ILE D 2 78  ? 36.69946 3.82452   8.56443   1.000 44.86971  ? 410 ILE D CB  1 
ATOM   2859 C CG1 . ILE D 2 78  ? 36.34208 4.23138   7.13276   1.000 43.01614  ? 410 ILE D CG1 1 
ATOM   2860 C CG2 . ILE D 2 78  ? 36.59316 5.02975   9.48776   1.000 44.62185  ? 410 ILE D CG2 1 
ATOM   2861 C CD1 . ILE D 2 78  ? 37.25800 5.28593   6.54382   1.000 39.81299  ? 410 ILE D CD1 1 
ATOM   2862 N N   . ALA D 2 79  ? 39.63593 2.15723   10.17119  1.000 45.06817  ? 411 ALA D N   1 
ATOM   2863 C CA  . ALA D 2 79  ? 40.03570 1.37357   11.32969  1.000 46.67740  ? 411 ALA D CA  1 
ATOM   2864 C C   . ALA D 2 79  ? 41.48796 1.69342   11.63300  1.000 48.06333  ? 411 ALA D C   1 
ATOM   2865 O O   . ALA D 2 79  ? 42.24176 2.04389   10.71825  1.000 48.20905  ? 411 ALA D O   1 
ATOM   2866 C CB  . ALA D 2 79  ? 39.85627 -0.12982  11.07399  1.000 47.26046  ? 411 ALA D CB  1 
ATOM   2867 N N   . PRO D 2 80  ? 41.90657 1.60349   12.89331  1.000 46.53451  ? 412 PRO D N   1 
ATOM   2868 C CA  . PRO D 2 80  ? 43.30215 1.91026   13.22673  1.000 51.73950  ? 412 PRO D CA  1 
ATOM   2869 C C   . PRO D 2 80  ? 44.27073 0.97140   12.52283  1.000 50.14963  ? 412 PRO D C   1 
ATOM   2870 O O   . PRO D 2 80  ? 43.98976 -0.21336  12.32831  1.000 51.31749  ? 412 PRO D O   1 
ATOM   2871 C CB  . PRO D 2 80  ? 43.34953 1.72812   14.74821  1.000 55.73905  ? 412 PRO D CB  1 
ATOM   2872 C CG  . PRO D 2 80  ? 41.94368 1.94229   15.19483  1.000 51.74380  ? 412 PRO D CG  1 
ATOM   2873 C CD  . PRO D 2 80  ? 41.08385 1.39202   14.09587  1.000 50.58998  ? 412 PRO D CD  1 
ATOM   2874 N N   . GLY D 2 81  ? 45.41907 1.52222   12.13509  1.000 49.92081  ? 413 GLY D N   1 
ATOM   2875 C CA  . GLY D 2 81  ? 46.47817 0.72809   11.53328  1.000 57.02047  ? 413 GLY D CA  1 
ATOM   2876 C C   . GLY D 2 81  ? 46.10910 0.05359   10.23084  1.000 58.38024  ? 413 GLY D C   1 
ATOM   2877 O O   . GLY D 2 81  ? 46.68568 -0.98657  9.89541   1.000 58.65277  ? 413 GLY D O   1 
ATOM   2878 N N   . GLN D 2 82  ? 45.16856 0.61716   9.48183   1.000 55.04091  ? 414 GLN D N   1 
ATOM   2879 C CA  . GLN D 2 82  ? 44.72747 0.04007   8.22176   1.000 54.15196  ? 414 GLN D CA  1 
ATOM   2880 C C   . GLN D 2 82  ? 45.38925 0.75495   7.04893   1.000 50.55575  ? 414 GLN D C   1 
ATOM   2881 O O   . GLN D 2 82  ? 45.81754 1.90664   7.15175   1.000 55.72894  ? 414 GLN D O   1 
ATOM   2882 C CB  . GLN D 2 82  ? 43.20351 0.11972   8.09541   1.000 52.23631  ? 414 GLN D CB  1 
ATOM   2883 C CG  . GLN D 2 82  ? 42.58239 -1.03173  7.32733   1.000 58.57061  ? 414 GLN D CG  1 
ATOM   2884 C CD  . GLN D 2 82  ? 42.60998 -2.33253  8.10685   1.000 57.49753  ? 414 GLN D CD  1 
ATOM   2885 O OE1 . GLN D 2 82  ? 42.82398 -2.33758  9.31874   1.000 61.88905  ? 414 GLN D OE1 1 
ATOM   2886 N NE2 . GLN D 2 82  ? 42.39163 -3.44437  7.41363   1.000 59.99269  ? 414 GLN D NE2 1 
ATOM   2887 N N   . THR D 2 83  ? 45.47810 0.04854   5.92632   1.000 53.68803  ? 415 THR D N   1 
ATOM   2888 C CA  . THR D 2 83  ? 46.02450 0.60374   4.69868   1.000 55.92460  ? 415 THR D CA  1 
ATOM   2889 C C   . THR D 2 83  ? 44.99869 0.49359   3.57942   1.000 53.41258  ? 415 THR D C   1 
ATOM   2890 O O   . THR D 2 83  ? 44.10520 -0.35706  3.60476   1.000 59.49900  ? 415 THR D O   1 
ATOM   2891 C CB  . THR D 2 83  ? 47.32407 -0.10140  4.28428   1.000 58.50568  ? 415 THR D CB  1 
ATOM   2892 O OG1 . THR D 2 83  ? 47.05525 -1.47841  3.99070   1.000 56.98215  ? 415 THR D OG1 1 
ATOM   2893 C CG2 . THR D 2 83  ? 48.35592 -0.01426  5.40209   1.000 61.84856  ? 415 THR D CG2 1 
ATOM   2894 N N   . GLY D 2 84  ? 45.13656 1.36628   2.59883   1.000 51.09680  ? 416 GLY D N   1 
ATOM   2895 C CA  . GLY D 2 84  ? 44.21885 1.39558   1.47693   1.000 49.17571  ? 416 GLY D CA  1 
ATOM   2896 C C   . GLY D 2 84  ? 44.10611 2.79462   0.91328   1.000 54.23167  ? 416 GLY D C   1 
ATOM   2897 O O   . GLY D 2 84  ? 44.59605 3.76646   1.48354   1.000 52.05104  ? 416 GLY D O   1 
ATOM   2898 N N   . LYS D 2 85  ? 43.43820 2.87854   -0.24150  1.000 58.06996  ? 417 LYS D N   1 
ATOM   2899 C CA  . LYS D 2 85  ? 43.26596 4.16258   -0.91565  1.000 51.24161  ? 417 LYS D CA  1 
ATOM   2900 C C   . LYS D 2 85  ? 42.62426 5.19289   0.00555   1.000 47.21754  ? 417 LYS D C   1 
ATOM   2901 O O   . LYS D 2 85  ? 43.04159 6.35626   0.03602   1.000 47.72474  ? 417 LYS D O   1 
ATOM   2902 C CB  . LYS D 2 85  ? 42.42557 3.97659   -2.17938  1.000 46.54663  ? 417 LYS D CB  1 
ATOM   2903 C CG  . LYS D 2 85  ? 42.16151 5.25826   -2.95144  1.000 46.70933  ? 417 LYS D CG  1 
ATOM   2904 C CD  . LYS D 2 85  ? 41.07333 5.05413   -3.99590  1.000 48.57645  ? 417 LYS D CD  1 
ATOM   2905 C CE  . LYS D 2 85  ? 41.41654 3.91291   -4.94212  1.000 49.85038  ? 417 LYS D CE  1 
ATOM   2906 N NZ  . LYS D 2 85  ? 40.26824 3.55542   -5.82063  1.000 43.52708  ? 417 LYS D NZ  1 
ATOM   2907 N N   . ILE D 2 86  ? 41.61489 4.78213   0.77167   1.000 49.04819  ? 418 ILE D N   1 
ATOM   2908 C CA  . ILE D 2 86  ? 40.93765 5.71281   1.66758   1.000 50.30071  ? 418 ILE D CA  1 
ATOM   2909 C C   . ILE D 2 86  ? 41.78036 5.98412   2.90632   1.000 43.68946  ? 418 ILE D C   1 
ATOM   2910 O O   . ILE D 2 86  ? 41.91665 7.13362   3.33696   1.000 44.84047  ? 418 ILE D O   1 
ATOM   2911 C CB  . ILE D 2 86  ? 39.54410 5.17156   2.03334   1.000 48.08975  ? 418 ILE D CB  1 
ATOM   2912 C CG1 . ILE D 2 86  ? 38.71767 4.94935   0.76326   1.000 44.75704  ? 418 ILE D CG1 1 
ATOM   2913 C CG2 . ILE D 2 86  ? 38.83487 6.11822   2.98610   1.000 42.50080  ? 418 ILE D CG2 1 
ATOM   2914 C CD1 . ILE D 2 86  ? 38.70332 6.14133   -0.17131  1.000 42.20741  ? 418 ILE D CD1 1 
ATOM   2915 N N   . ALA D 2 87  ? 42.36750 4.93896   3.49080   1.000 45.14466  ? 419 ALA D N   1 
ATOM   2916 C CA  . ALA D 2 87  ? 43.13469 5.11579   4.71858   1.000 44.91738  ? 419 ALA D CA  1 
ATOM   2917 C C   . ALA D 2 87  ? 44.41205 5.90961   4.47010   1.000 49.20072  ? 419 ALA D C   1 
ATOM   2918 O O   . ALA D 2 87  ? 44.81678 6.72218   5.31027   1.000 47.91270  ? 419 ALA D O   1 
ATOM   2919 C CB  . ALA D 2 87  ? 43.45675 3.75558   5.33510   1.000 43.89065  ? 419 ALA D CB  1 
ATOM   2920 N N   . ASP D 2 88  ? 45.05608 5.69824   3.32098   1.000 48.06642  ? 420 ASP D N   1 
ATOM   2921 C CA  . ASP D 2 88  ? 46.32077 6.37365   3.05171   1.000 47.64299  ? 420 ASP D CA  1 
ATOM   2922 C C   . ASP D 2 88  ? 46.12001 7.83880   2.68193   1.000 46.25096  ? 420 ASP D C   1 
ATOM   2923 O O   . ASP D 2 88  ? 46.85192 8.70686   3.16813   1.000 50.52479  ? 420 ASP D O   1 
ATOM   2924 C CB  . ASP D 2 88  ? 47.08061 5.65620   1.93385   1.000 54.36340  ? 420 ASP D CB  1 
ATOM   2925 C CG  . ASP D 2 88  ? 47.45121 4.23068   2.29582   1.000 57.36659  ? 420 ASP D CG  1 
ATOM   2926 O OD1 . ASP D 2 88  ? 46.96708 3.72987   3.33203   1.000 54.72885  ? 420 ASP D OD1 1 
ATOM   2927 O OD2 . ASP D 2 88  ? 48.22888 3.61093   1.53984   1.000 55.54315  ? 420 ASP D OD2 1 
ATOM   2928 N N   . TYR D 2 89  ? 45.14455 8.13836   1.82267   1.000 47.61297  ? 421 TYR D N   1 
ATOM   2929 C CA  . TYR D 2 89  ? 45.04795 9.45822   1.21512   1.000 47.93068  ? 421 TYR D CA  1 
ATOM   2930 C C   . TYR D 2 89  ? 43.81299 10.25687  1.61231   1.000 43.06526  ? 421 TYR D C   1 
ATOM   2931 O O   . TYR D 2 89  ? 43.75058 11.45010  1.29475   1.000 41.13398  ? 421 TYR D O   1 
ATOM   2932 C CB  . TYR D 2 89  ? 45.07908 9.34404   -0.31942  1.000 47.41771  ? 421 TYR D CB  1 
ATOM   2933 C CG  . TYR D 2 89  ? 46.30110 8.64320   -0.88196  1.000 50.26996  ? 421 TYR D CG  1 
ATOM   2934 C CD1 . TYR D 2 89  ? 47.49989 8.61531   -0.18088  1.000 50.16351  ? 421 TYR D CD1 1 
ATOM   2935 C CD2 . TYR D 2 89  ? 46.25332 8.01219   -2.12102  1.000 49.61555  ? 421 TYR D CD2 1 
ATOM   2936 C CE1 . TYR D 2 89  ? 48.61401 7.97574   -0.69256  1.000 53.90439  ? 421 TYR D CE1 1 
ATOM   2937 C CE2 . TYR D 2 89  ? 47.36363 7.36997   -2.64100  1.000 50.12494  ? 421 TYR D CE2 1 
ATOM   2938 C CZ  . TYR D 2 89  ? 48.54066 7.35606   -1.92309  1.000 52.25233  ? 421 TYR D CZ  1 
ATOM   2939 O OH  . TYR D 2 89  ? 49.64874 6.72105   -2.43190  1.000 47.28927  ? 421 TYR D OH  1 
ATOM   2940 N N   . ASN D 2 90  ? 42.83459 9.65427   2.28862   1.000 42.68937  ? 422 ASN D N   1 
ATOM   2941 C CA  . ASN D 2 90  ? 41.57397 10.33680  2.56523   1.000 37.79493  ? 422 ASN D CA  1 
ATOM   2942 C C   . ASN D 2 90  ? 41.32236 10.53340  4.05385   1.000 42.69877  ? 422 ASN D C   1 
ATOM   2943 O O   . ASN D 2 90  ? 41.13808 11.67481  4.48972   1.000 40.79795  ? 422 ASN D O   1 
ATOM   2944 C CB  . ASN D 2 90  ? 40.41273 9.57316   1.91917   1.000 40.88491  ? 422 ASN D CB  1 
ATOM   2945 C CG  . ASN D 2 90  ? 40.41560 9.68614   0.40867   1.000 40.76970  ? 422 ASN D CG  1 
ATOM   2946 O OD1 . ASN D 2 90  ? 39.82867 10.60777  -0.15426  1.000 38.86607  ? 422 ASN D OD1 1 
ATOM   2947 N ND2 . ASN D 2 90  ? 41.08081 8.74908   -0.25467  1.000 40.46673  ? 422 ASN D ND2 1 
ATOM   2948 N N   . TYR D 2 91  ? 41.30213 9.46601   4.85007   1.000 41.14491  ? 423 TYR D N   1 
ATOM   2949 C CA  . TYR D 2 91  ? 40.94792 9.58238   6.26282   1.000 45.49044  ? 423 TYR D CA  1 
ATOM   2950 C C   . TYR D 2 91  ? 41.66009 8.49365   7.05064   1.000 44.62497  ? 423 TYR D C   1 
ATOM   2951 O O   . TYR D 2 91  ? 41.37690 7.30682   6.86291   1.000 43.21801  ? 423 TYR D O   1 
ATOM   2952 C CB  . TYR D 2 91  ? 39.43278 9.48508   6.45103   1.000 39.61946  ? 423 TYR D CB  1 
ATOM   2953 C CG  . TYR D 2 91  ? 38.97658 9.69401   7.87521   1.000 42.30597  ? 423 TYR D CG  1 
ATOM   2954 C CD1 . TYR D 2 91  ? 38.72872 10.96883  8.36512   1.000 43.00293  ? 423 TYR D CD1 1 
ATOM   2955 C CD2 . TYR D 2 91  ? 38.79021 8.61679   8.72995   1.000 44.15847  ? 423 TYR D CD2 1 
ATOM   2956 C CE1 . TYR D 2 91  ? 38.31041 11.16526  9.66777   1.000 40.48401  ? 423 TYR D CE1 1 
ATOM   2957 C CE2 . TYR D 2 91  ? 38.37269 8.80396   10.03226  1.000 43.75997  ? 423 TYR D CE2 1 
ATOM   2958 C CZ  . TYR D 2 91  ? 38.13395 10.07875  10.49585  1.000 38.23372  ? 423 TYR D CZ  1 
ATOM   2959 O OH  . TYR D 2 91  ? 37.71663 10.26445  11.79287  1.000 44.72255  ? 423 TYR D OH  1 
ATOM   2960 N N   . LYS D 2 92  ? 42.56638 8.89543   7.93772   1.000 41.89036  ? 424 LYS D N   1 
ATOM   2961 C CA  . LYS D 2 92  ? 43.40206 7.96771   8.68879   1.000 46.59476  ? 424 LYS D CA  1 
ATOM   2962 C C   . LYS D 2 92  ? 43.02206 7.99079   10.16351  1.000 47.75551  ? 424 LYS D C   1 
ATOM   2963 O O   . LYS D 2 92  ? 43.02039 9.05348   10.79462  1.000 44.78336  ? 424 LYS D O   1 
ATOM   2964 C CB  . LYS D 2 92  ? 44.88451 8.31431   8.52990   1.000 48.62318  ? 424 LYS D CB  1 
ATOM   2965 C CG  . LYS D 2 92  ? 45.82362 7.30045   9.16278   1.000 47.14197  ? 424 LYS D CG  1 
ATOM   2966 C CD  . LYS D 2 92  ? 45.89906 6.03621   8.32340   1.000 56.20166  ? 424 LYS D CD  1 
ATOM   2967 C CE  . LYS D 2 92  ? 46.57445 4.90109   9.07151   1.000 44.61533  ? 424 LYS D CE  1 
ATOM   2968 N NZ  . LYS D 2 92  ? 45.67284 4.32465   10.10531  1.000 57.95226  ? 424 LYS D NZ  1 
ATOM   2969 N N   . LEU D 2 93  ? 42.71343 6.81883   10.70894  1.000 48.13265  ? 425 LEU D N   1 
ATOM   2970 C CA  . LEU D 2 93  ? 42.47557 6.75447   12.14524  1.000 49.28108  ? 425 LEU D CA  1 
ATOM   2971 C C   . LEU D 2 93  ? 43.77430 6.43546   12.88143  1.000 48.66501  ? 425 LEU D C   1 
ATOM   2972 O O   . LEU D 2 93  ? 44.57189 5.62010   12.40834  1.000 51.09920  ? 425 LEU D O   1 
ATOM   2973 C CB  . LEU D 2 93  ? 41.42787 5.69549   12.47537  1.000 45.31443  ? 425 LEU D CB  1 
ATOM   2974 C CG  . LEU D 2 93  ? 39.97869 6.06090   12.14986  1.000 42.83816  ? 425 LEU D CG  1 
ATOM   2975 C CD1 . LEU D 2 93  ? 39.05345 4.88475   12.41441  1.000 41.91129  ? 425 LEU D CD1 1 
ATOM   2976 C CD2 . LEU D 2 93  ? 39.54792 7.27481   12.95792  1.000 44.65472  ? 425 LEU D CD2 1 
ATOM   2977 N N   . PRO D 2 94  ? 44.00862 7.06341   14.03010  1.000 52.65582  ? 426 PRO D N   1 
ATOM   2978 C CA  . PRO D 2 94  ? 45.23010 6.78064   14.79023  1.000 54.80136  ? 426 PRO D CA  1 
ATOM   2979 C C   . PRO D 2 94  ? 45.25196 5.34813   15.29832  1.000 53.56064  ? 426 PRO D C   1 
ATOM   2980 O O   . PRO D 2 94  ? 44.21761 4.69722   15.46017  1.000 47.37203  ? 426 PRO D O   1 
ATOM   2981 C CB  . PRO D 2 94  ? 45.16642 7.77844   15.95023  1.000 52.30164  ? 426 PRO D CB  1 
ATOM   2982 C CG  . PRO D 2 94  ? 43.71003 8.07769   16.10232  1.000 53.62822  ? 426 PRO D CG  1 
ATOM   2983 C CD  . PRO D 2 94  ? 43.14736 8.04426   14.71017  1.000 53.42562  ? 426 PRO D CD  1 
ATOM   2984 N N   . ASP D 2 95  ? 46.47024 4.85733   15.54200  1.000 55.23216  ? 427 ASP D N   1 
ATOM   2985 C CA  . ASP D 2 95  ? 46.63270 3.49959   16.05389  1.000 61.01648  ? 427 ASP D CA  1 
ATOM   2986 C C   . ASP D 2 95  ? 45.96615 3.33942   17.41407  1.000 60.80213  ? 427 ASP D C   1 
ATOM   2987 O O   . ASP D 2 95  ? 45.33329 2.31242   17.68793  1.000 61.03483  ? 427 ASP D O   1 
ATOM   2988 C CB  . ASP D 2 95  ? 48.11615 3.14663   16.14293  1.000 62.14897  ? 427 ASP D CB  1 
ATOM   2989 C CG  . ASP D 2 95  ? 48.83714 3.33601   14.82821  1.000 62.62984  ? 427 ASP D CG  1 
ATOM   2990 O OD1 . ASP D 2 95  ? 48.98382 4.49823   14.39405  1.000 68.67071  ? 427 ASP D OD1 1 
ATOM   2991 O OD2 . ASP D 2 95  ? 49.25764 2.32399   14.22963  1.000 70.61213  ? 427 ASP D OD2 1 
ATOM   2992 N N   . ASP D 2 96  ? 46.09617 4.34366   18.27797  1.000 55.25650  ? 428 ASP D N   1 
ATOM   2993 C CA  . ASP D 2 96  ? 45.46000 4.33744   19.59468  1.000 65.00708  ? 428 ASP D CA  1 
ATOM   2994 C C   . ASP D 2 96  ? 44.08151 4.98137   19.56943  1.000 62.11389  ? 428 ASP D C   1 
ATOM   2995 O O   . ASP D 2 96  ? 43.71140 5.70881   20.49591  1.000 60.13438  ? 428 ASP D O   1 
ATOM   2996 C CB  . ASP D 2 96  ? 46.36685 5.03006   20.60857  1.000 57.07118  ? 428 ASP D CB  1 
ATOM   2997 C CG  . ASP D 2 96  ? 46.76772 6.43317   20.17914  1.000 63.23983  ? 428 ASP D CG  1 
ATOM   2998 O OD1 . ASP D 2 96  ? 46.25652 6.92161   19.14860  1.000 66.83331  ? 428 ASP D OD1 1 
ATOM   2999 O OD2 . ASP D 2 96  ? 47.60282 7.04945   20.87343  1.000 66.52984  ? 428 ASP D OD2 1 
ATOM   3000 N N   . PHE D 2 97  ? 43.30218 4.73366   18.51872  1.000 57.02617  ? 429 PHE D N   1 
ATOM   3001 C CA  . PHE D 2 97  ? 41.98929 5.35329   18.38898  1.000 56.09145  ? 429 PHE D CA  1 
ATOM   3002 C C   . PHE D 2 97  ? 41.02727 4.77458   19.41896  1.000 60.31746  ? 429 PHE D C   1 
ATOM   3003 O O   . PHE D 2 97  ? 40.78951 3.56205   19.45015  1.000 61.36980  ? 429 PHE D O   1 
ATOM   3004 C CB  . PHE D 2 97  ? 41.44224 5.15504   16.97760  1.000 52.77183  ? 429 PHE D CB  1 
ATOM   3005 C CG  . PHE D 2 97  ? 40.01814 5.60483   16.81165  1.000 48.46763  ? 429 PHE D CG  1 
ATOM   3006 C CD1 . PHE D 2 97  ? 39.69067 6.95003   16.86818  1.000 47.18927  ? 429 PHE D CD1 1 
ATOM   3007 C CD2 . PHE D 2 97  ? 39.00753 4.68332   16.59338  1.000 44.15793  ? 429 PHE D CD2 1 
ATOM   3008 C CE1 . PHE D 2 97  ? 38.38193 7.36676   16.71576  1.000 41.17263  ? 429 PHE D CE1 1 
ATOM   3009 C CE2 . PHE D 2 97  ? 37.69780 5.09440   16.43845  1.000 40.78991  ? 429 PHE D CE2 1 
ATOM   3010 C CZ  . PHE D 2 97  ? 37.38506 6.43815   16.50048  1.000 38.15861  ? 429 PHE D CZ  1 
ATOM   3011 N N   . THR D 2 98  ? 40.47886 5.64350   20.26054  1.000 59.13312  ? 430 THR D N   1 
ATOM   3012 C CA  . THR D 2 98  ? 39.43592 5.28477   21.21562  1.000 59.97193  ? 430 THR D CA  1 
ATOM   3013 C C   . THR D 2 98  ? 38.13807 5.91082   20.71359  1.000 59.66801  ? 430 THR D C   1 
ATOM   3014 O O   . THR D 2 98  ? 37.93522 7.12416   20.82762  1.000 50.17259  ? 430 THR D O   1 
ATOM   3015 C CB  . THR D 2 98  ? 39.79004 5.75721   22.62403  1.000 57.90978  ? 430 THR D CB  1 
ATOM   3016 O OG1 . THR D 2 98  ? 40.11749 7.15248   22.59654  1.000 58.76763  ? 430 THR D OG1 1 
ATOM   3017 C CG2 . THR D 2 98  ? 40.97937 4.97707   23.16268  1.000 54.70085  ? 430 THR D CG2 1 
ATOM   3018 N N   . GLY D 2 99  ? 37.27384 5.08353   20.14048  1.000 53.29654  ? 431 GLY D N   1 
ATOM   3019 C CA  . GLY D 2 99  ? 36.01441 5.57750   19.62356  1.000 47.52198  ? 431 GLY D CA  1 
ATOM   3020 C C   . GLY D 2 99  ? 35.26318 4.47772   18.91027  1.000 48.14254  ? 431 GLY D C   1 
ATOM   3021 O O   . GLY D 2 99  ? 35.61766 3.30004   18.99473  1.000 47.24630  ? 431 GLY D O   1 
ATOM   3022 N N   . CYS D 2 100 ? 34.21357 4.88055   18.19913  1.000 43.36666  ? 432 CYS D N   1 
ATOM   3023 C CA  . CYS D 2 100 ? 33.37033 3.95178   17.46178  1.000 44.52807  ? 432 CYS D CA  1 
ATOM   3024 C C   . CYS D 2 100 ? 33.28235 4.37801   16.00402  1.000 45.40935  ? 432 CYS D C   1 
ATOM   3025 O O   . CYS D 2 100 ? 33.23682 5.57387   15.69813  1.000 41.30892  ? 432 CYS D O   1 
ATOM   3026 C CB  . CYS D 2 100 ? 31.96372 3.87678   18.06471  1.000 44.18691  ? 432 CYS D CB  1 
ATOM   3027 S SG  . CYS D 2 100 ? 31.91486 3.46662   19.82907  1.000 54.28441  ? 432 CYS D SG  1 
ATOM   3028 N N   . VAL D 2 101 ? 33.26176 3.39219   15.11009  1.000 47.80293  ? 433 VAL D N   1 
ATOM   3029 C CA  . VAL D 2 101 ? 33.08044 3.60916   13.67811  1.000 40.94634  ? 433 VAL D CA  1 
ATOM   3030 C C   . VAL D 2 101 ? 31.71400 3.05997   13.29647  1.000 44.39164  ? 433 VAL D C   1 
ATOM   3031 O O   . VAL D 2 101 ? 31.45656 1.85871   13.44358  1.000 44.96619  ? 433 VAL D O   1 
ATOM   3032 C CB  . VAL D 2 101 ? 34.19013 2.94113   12.85264  1.000 39.22947  ? 433 VAL D CB  1 
ATOM   3033 C CG1 . VAL D 2 101 ? 33.92022 3.11863   11.36934  1.000 40.76955  ? 433 VAL D CG1 1 
ATOM   3034 C CG2 . VAL D 2 101 ? 35.54923 3.51106   13.22752  1.000 41.44579  ? 433 VAL D CG2 1 
ATOM   3035 N N   . ILE D 2 102 ? 30.84117 3.93355   12.80354  1.000 42.28227  ? 434 ILE D N   1 
ATOM   3036 C CA  . ILE D 2 102 ? 29.46479 3.58273   12.47659  1.000 40.55614  ? 434 ILE D CA  1 
ATOM   3037 C C   . ILE D 2 102 ? 29.25533 3.78993   10.98244  1.000 43.79848  ? 434 ILE D C   1 
ATOM   3038 O O   . ILE D 2 102 ? 29.66890 4.81558   10.42974  1.000 39.25849  ? 434 ILE D O   1 
ATOM   3039 C CB  . ILE D 2 102 ? 28.46801 4.41764   13.29909  1.000 40.44811  ? 434 ILE D CB  1 
ATOM   3040 C CG1 . ILE D 2 102 ? 28.78661 4.28580   14.79165  1.000 46.23781  ? 434 ILE D CG1 1 
ATOM   3041 C CG2 . ILE D 2 102 ? 27.04565 3.97921   13.02131  1.000 40.63858  ? 434 ILE D CG2 1 
ATOM   3042 C CD1 . ILE D 2 102 ? 28.08376 5.30333   15.66236  1.000 42.38797  ? 434 ILE D CD1 1 
ATOM   3043 N N   . ALA D 2 103 ? 28.61615 2.81811   10.33281  1.000 48.45090  ? 435 ALA D N   1 
ATOM   3044 C CA  . ALA D 2 103 ? 28.40036 2.87290   8.89376   1.000 49.57471  ? 435 ALA D CA  1 
ATOM   3045 C C   . ALA D 2 103 ? 27.12746 2.11819   8.53959   1.000 48.90819  ? 435 ALA D C   1 
ATOM   3046 O O   . ALA D 2 103 ? 26.75711 1.14887   9.20682   1.000 52.37579  ? 435 ALA D O   1 
ATOM   3047 C CB  . ALA D 2 103 ? 29.59152 2.29160   8.12277   1.000 39.81218  ? 435 ALA D CB  1 
ATOM   3048 N N   . TRP D 2 104 ? 26.46385 2.57251   7.47742   1.000 51.45289  ? 436 TRP D N   1 
ATOM   3049 C CA  . TRP D 2 104 ? 25.23923 1.94270   7.00554   1.000 51.81446  ? 436 TRP D CA  1 
ATOM   3050 C C   . TRP D 2 104 ? 25.07496 2.21727   5.51504   1.000 53.76563  ? 436 TRP D C   1 
ATOM   3051 O O   . TRP D 2 104 ? 25.56769 3.22262   4.99559   1.000 54.00050  ? 436 TRP D O   1 
ATOM   3052 C CB  . TRP D 2 104 ? 24.01551 2.44042   7.78741   1.000 45.01853  ? 436 TRP D CB  1 
ATOM   3053 C CG  . TRP D 2 104 ? 23.68449 3.88461   7.54916   1.000 49.99234  ? 436 TRP D CG  1 
ATOM   3054 C CD1 . TRP D 2 104 ? 22.84875 4.38598   6.59330   1.000 51.56159  ? 436 TRP D CD1 1 
ATOM   3055 C CD2 . TRP D 2 104 ? 24.17663 5.01361   8.28210   1.000 49.30489  ? 436 TRP D CD2 1 
ATOM   3056 N NE1 . TRP D 2 104 ? 22.79182 5.75544   6.68372   1.000 52.96337  ? 436 TRP D NE1 1 
ATOM   3057 C CE2 . TRP D 2 104 ? 23.59748 6.16623   7.71278   1.000 51.80657  ? 436 TRP D CE2 1 
ATOM   3058 C CE3 . TRP D 2 104 ? 25.05099 5.16241   9.36303   1.000 54.17573  ? 436 TRP D CE3 1 
ATOM   3059 C CZ2 . TRP D 2 104 ? 23.86396 7.44980   8.18808   1.000 46.13235  ? 436 TRP D CZ2 1 
ATOM   3060 C CZ3 . TRP D 2 104 ? 25.31456 6.43875   9.83398   1.000 51.77202  ? 436 TRP D CZ3 1 
ATOM   3061 C CH2 . TRP D 2 104 ? 24.72340 7.56490   9.24575   1.000 48.40996  ? 436 TRP D CH2 1 
ATOM   3062 N N   . ASN D 2 105 ? 24.37506 1.31130   4.83356   1.000 49.00994  ? 437 ASN D N   1 
ATOM   3063 C CA  . ASN D 2 105 ? 24.19371 1.42281   3.39125   1.000 45.98903  ? 437 ASN D CA  1 
ATOM   3064 C C   . ASN D 2 105 ? 23.31125 2.61815   3.05128   1.000 49.57101  ? 437 ASN D C   1 
ATOM   3065 O O   . ASN D 2 105 ? 22.20171 2.75340   3.57535   1.000 53.21172  ? 437 ASN D O   1 
ATOM   3066 C CB  . ASN D 2 105 ? 23.57560 0.13962   2.83646   1.000 47.85689  ? 437 ASN D CB  1 
ATOM   3067 C CG  . ASN D 2 105 ? 23.47159 0.14635   1.31982   1.000 50.74848  ? 437 ASN D CG  1 
ATOM   3068 O OD1 . ASN D 2 105 ? 22.64646 0.85616   0.74285   1.000 44.18073  ? 437 ASN D OD1 1 
ATOM   3069 N ND2 . ASN D 2 105 ? 24.30304 -0.65837  0.66808   1.000 47.26484  ? 437 ASN D ND2 1 
ATOM   3070 N N   . SER D 2 106 ? 23.79947 3.47954   2.15672   1.000 47.67857  ? 438 SER D N   1 
ATOM   3071 C CA  . SER D 2 106 ? 23.06815 4.66733   1.73188   1.000 44.10492  ? 438 SER D CA  1 
ATOM   3072 C C   . SER D 2 106 ? 22.82463 4.66841   0.22701   1.000 48.94408  ? 438 SER D C   1 
ATOM   3073 O O   . SER D 2 106 ? 22.79273 5.72846   -0.40131  1.000 51.21138  ? 438 SER D O   1 
ATOM   3074 C CB  . SER D 2 106 ? 23.80755 5.93696   2.14671   1.000 45.18154  ? 438 SER D CB  1 
ATOM   3075 O OG  . SER D 2 106 ? 25.01598 6.08360   1.42037   1.000 43.38441  ? 438 SER D OG  1 
ATOM   3076 N N   . ASN D 2 107 ? 22.65358 3.48395   -0.36475  1.000 45.40376  ? 439 ASN D N   1 
ATOM   3077 C CA  . ASN D 2 107 ? 22.40426 3.41260   -1.79981  1.000 50.42606  ? 439 ASN D CA  1 
ATOM   3078 C C   . ASN D 2 107 ? 21.07915 4.06269   -2.17466  1.000 53.84369  ? 439 ASN D C   1 
ATOM   3079 O O   . ASN D 2 107 ? 20.94665 4.60492   -3.27676  1.000 51.45105  ? 439 ASN D O   1 
ATOM   3080 C CB  . ASN D 2 107 ? 22.43236 1.95943   -2.26984  1.000 52.83215  ? 439 ASN D CB  1 
ATOM   3081 C CG  . ASN D 2 107 ? 22.28461 1.83285   -3.77092  1.000 51.94453  ? 439 ASN D CG  1 
ATOM   3082 O OD1 . ASN D 2 107 ? 23.23063 2.07333   -4.51924  1.000 55.31220  ? 439 ASN D OD1 1 
ATOM   3083 N ND2 . ASN D 2 107 ? 21.09464 1.45311   -4.21991  1.000 49.91458  ? 439 ASN D ND2 1 
ATOM   3084 N N   . ASN D 2 108 ? 20.09203 4.02477   -1.27825  1.000 54.78435  ? 440 ASN D N   1 
ATOM   3085 C CA  . ASN D 2 108 ? 18.81383 4.66046   -1.57503  1.000 54.12006  ? 440 ASN D CA  1 
ATOM   3086 C C   . ASN D 2 108 ? 18.93046 6.17871   -1.58698  1.000 51.17564  ? 440 ASN D C   1 
ATOM   3087 O O   . ASN D 2 108 ? 18.16782 6.85197   -2.28831  1.000 55.82179  ? 440 ASN D O   1 
ATOM   3088 C CB  . ASN D 2 108 ? 17.76121 4.22155   -0.55868  1.000 51.28220  ? 440 ASN D CB  1 
ATOM   3089 C CG  . ASN D 2 108 ? 18.16626 4.53770   0.86496   1.000 56.99123  ? 440 ASN D CG  1 
ATOM   3090 O OD1 . ASN D 2 108 ? 19.30056 4.28242   1.26915   1.000 62.04897  ? 440 ASN D OD1 1 
ATOM   3091 N ND2 . ASN D 2 108 ? 17.24490 5.10937   1.63060   1.000 55.73712  ? 440 ASN D ND2 1 
ATOM   3092 N N   . LEU D 2 109 ? 19.87594 6.73339   -0.83115  1.000 56.96230  ? 441 LEU D N   1 
ATOM   3093 C CA  . LEU D 2 109 ? 19.99001 8.17753   -0.67885  1.000 53.59478  ? 441 LEU D CA  1 
ATOM   3094 C C   . LEU D 2 109 ? 21.06083 8.80148   -1.55932  1.000 51.09432  ? 441 LEU D C   1 
ATOM   3095 O O   . LEU D 2 109 ? 20.89006 9.94285   -1.99991  1.000 54.68901  ? 441 LEU D O   1 
ATOM   3096 C CB  . LEU D 2 109 ? 20.28177 8.53390   0.78413   1.000 50.50573  ? 441 LEU D CB  1 
ATOM   3097 C CG  . LEU D 2 109 ? 19.27534 8.03718   1.82429   1.000 58.27822  ? 441 LEU D CG  1 
ATOM   3098 C CD1 . LEU D 2 109 ? 19.66286 8.50565   3.22379   1.000 56.08563  ? 441 LEU D CD1 1 
ATOM   3099 C CD2 . LEU D 2 109 ? 17.86603 8.49002   1.47191   1.000 54.18606  ? 441 LEU D CD2 1 
ATOM   3100 N N   . ASP D 2 110 ? 22.15443 8.08935   -1.83205  1.000 48.32389  ? 442 ASP D N   1 
ATOM   3101 C CA  . ASP D 2 110 ? 23.30023 8.66539   -2.52456  1.000 49.17342  ? 442 ASP D CA  1 
ATOM   3102 C C   . ASP D 2 110 ? 23.53112 8.07184   -3.91160  1.000 51.31718  ? 442 ASP D C   1 
ATOM   3103 O O   . ASP D 2 110 ? 24.57668 8.33171   -4.51642  1.000 49.59078  ? 442 ASP D O   1 
ATOM   3104 C CB  . ASP D 2 110 ? 24.56110 8.50826   -1.67069  1.000 50.89272  ? 442 ASP D CB  1 
ATOM   3105 C CG  . ASP D 2 110 ? 24.42983 9.15893   -0.30406  1.000 46.33263  ? 442 ASP D CG  1 
ATOM   3106 O OD1 . ASP D 2 110 ? 23.79679 10.23246  -0.20504  1.000 46.92420  ? 442 ASP D OD1 1 
ATOM   3107 O OD2 . ASP D 2 110 ? 24.96326 8.59281   0.67202   1.000 44.64147  ? 442 ASP D OD2 1 
ATOM   3108 N N   . SER D 2 111 ? 22.59270 7.28574   -4.43198  1.000 55.11665  ? 443 SER D N   1 
ATOM   3109 C CA  . SER D 2 111 ? 22.66299 6.78286   -5.79765  1.000 56.74634  ? 443 SER D CA  1 
ATOM   3110 C C   . SER D 2 111 ? 21.56544 7.42431   -6.63412  1.000 56.16374  ? 443 SER D C   1 
ATOM   3111 O O   . SER D 2 111 ? 20.43649 7.60191   -6.16501  1.000 55.60030  ? 443 SER D O   1 
ATOM   3112 C CB  . SER D 2 111 ? 22.52744 5.25661   -5.84853  1.000 53.96729  ? 443 SER D CB  1 
ATOM   3113 O OG  . SER D 2 111 ? 23.63697 4.61507   -5.24315  1.000 54.94765  ? 443 SER D OG  1 
ATOM   3114 N N   . LYS D 2 112 ? 21.90263 7.77185   -7.87258  1.000 56.36167  ? 444 LYS D N   1 
ATOM   3115 C CA  . LYS D 2 112 ? 20.96361 8.39739   -8.78888  1.000 56.71322  ? 444 LYS D CA  1 
ATOM   3116 C C   . LYS D 2 112 ? 21.02234 7.68596   -10.13229 1.000 60.15301  ? 444 LYS D C   1 
ATOM   3117 O O   . LYS D 2 112 ? 22.04817 7.10521   -10.50042 1.000 56.98486  ? 444 LYS D O   1 
ATOM   3118 C CB  . LYS D 2 112 ? 21.26602 9.89617   -8.96461  1.000 56.82152  ? 444 LYS D CB  1 
ATOM   3119 C CG  . LYS D 2 112 ? 20.12511 10.69934  -9.56950  1.000 62.90866  ? 444 LYS D CG  1 
ATOM   3120 C CD  . LYS D 2 112 ? 20.46356 12.17983  -9.65889  1.000 60.89056  ? 444 LYS D CD  1 
ATOM   3121 C CE  . LYS D 2 112 ? 21.63731 12.42878  -10.59050 1.000 59.93832  ? 444 LYS D CE  1 
ATOM   3122 N NZ  . LYS D 2 112 ? 21.91129 13.88277  -10.75443 1.000 59.04648  ? 444 LYS D NZ  1 
ATOM   3123 N N   . VAL D 2 113 ? 19.90054 7.72432   -10.85621 1.000 64.01732  ? 445 VAL D N   1 
ATOM   3124 C CA  . VAL D 2 113 ? 19.85680 7.13980   -12.19015 1.000 61.14407  ? 445 VAL D CA  1 
ATOM   3125 C C   . VAL D 2 113 ? 20.88216 7.83148   -13.07401 1.000 53.60297  ? 445 VAL D C   1 
ATOM   3126 O O   . VAL D 2 113 ? 20.89484 9.06256   -13.20165 1.000 58.00045  ? 445 VAL D O   1 
ATOM   3127 C CB  . VAL D 2 113 ? 18.43929 7.23750   -12.77229 1.000 66.29984  ? 445 VAL D CB  1 
ATOM   3128 C CG1 . VAL D 2 113 ? 17.54644 6.17265   -12.15489 1.000 62.44257  ? 445 VAL D CG1 1 
ATOM   3129 C CG2 . VAL D 2 113 ? 17.85645 8.62424   -12.52598 1.000 67.85416  ? 445 VAL D CG2 1 
ATOM   3130 N N   . GLY D 2 114 ? 21.76071 7.03796   -13.67984 1.000 50.94356  ? 446 GLY D N   1 
ATOM   3131 C CA  . GLY D 2 114 ? 22.88656 7.55700   -14.41475 1.000 51.75421  ? 446 GLY D CA  1 
ATOM   3132 C C   . GLY D 2 114 ? 24.12789 7.78617   -13.58070 1.000 53.52164  ? 446 GLY D C   1 
ATOM   3133 O O   . GLY D 2 114 ? 25.23065 7.85205   -14.13711 1.000 60.25688  ? 446 GLY D O   1 
ATOM   3134 N N   . GLY D 2 115 ? 23.98253 7.90871   -12.26544 1.000 59.56330  ? 447 GLY D N   1 
ATOM   3135 C CA  . GLY D 2 115 ? 25.15893 8.04730   -11.41838 1.000 48.90921  ? 447 GLY D CA  1 
ATOM   3136 C C   . GLY D 2 115 ? 25.16574 9.36432   -10.66617 1.000 53.99951  ? 447 GLY D C   1 
ATOM   3137 O O   . GLY D 2 115 ? 24.95142 10.43967  -11.22540 1.000 47.12690  ? 447 GLY D O   1 
ATOM   3138 N N   . ASN D 2 116 ? 25.41306 9.26701   -9.36341  1.000 55.21934  ? 448 ASN D N   1 
ATOM   3139 C CA  . ASN D 2 116 ? 25.64668 10.42799  -8.51667  1.000 44.10678  ? 448 ASN D CA  1 
ATOM   3140 C C   . ASN D 2 116 ? 27.15189 10.62226  -8.38993  1.000 44.81787  ? 448 ASN D C   1 
ATOM   3141 O O   . ASN D 2 116 ? 27.86291 9.72173   -7.92932  1.000 44.12629  ? 448 ASN D O   1 
ATOM   3142 C CB  . ASN D 2 116 ? 25.00006 10.24954  -7.14384  1.000 51.81132  ? 448 ASN D CB  1 
ATOM   3143 C CG  . ASN D 2 116 ? 25.26514 11.42194  -6.21459  1.000 50.93356  ? 448 ASN D CG  1 
ATOM   3144 O OD1 . ASN D 2 116 ? 25.54703 12.53593  -6.65898  1.000 49.88325  ? 448 ASN D OD1 1 
ATOM   3145 N ND2 . ASN D 2 116 ? 25.17783 11.17206  -4.91438  1.000 50.29110  ? 448 ASN D ND2 1 
ATOM   3146 N N   . TYR D 2 117 ? 27.63421 11.78943  -8.80881  1.000 47.53888  ? 449 TYR D N   1 
ATOM   3147 C CA  . TYR D 2 117 ? 29.06023 12.08822  -8.82723  1.000 46.34663  ? 449 TYR D CA  1 
ATOM   3148 C C   . TYR D 2 117 ? 29.39280 13.26507  -7.91598  1.000 49.45461  ? 449 TYR D C   1 
ATOM   3149 O O   . TYR D 2 117 ? 30.38766 13.96182  -8.12541  1.000 52.52979  ? 449 TYR D O   1 
ATOM   3150 C CB  . TYR D 2 117 ? 29.53299 12.35327  -10.25703 1.000 44.70813  ? 449 TYR D CB  1 
ATOM   3151 C CG  . TYR D 2 117 ? 29.27124 11.19743  -11.20017 1.000 49.14157  ? 449 TYR D CG  1 
ATOM   3152 C CD1 . TYR D 2 117 ? 28.07775 11.10794  -11.90622 1.000 49.16907  ? 449 TYR D CD1 1 
ATOM   3153 C CD2 . TYR D 2 117 ? 30.21241 10.19083  -11.37637 1.000 46.63900  ? 449 TYR D CD2 1 
ATOM   3154 C CE1 . TYR D 2 117 ? 27.83082 10.05249  -12.76310 1.000 51.18560  ? 449 TYR D CE1 1 
ATOM   3155 C CE2 . TYR D 2 117 ? 29.97424 9.13147   -12.23207 1.000 48.30812  ? 449 TYR D CE2 1 
ATOM   3156 C CZ  . TYR D 2 117 ? 28.78168 9.06736   -12.92259 1.000 53.08602  ? 449 TYR D CZ  1 
ATOM   3157 O OH  . TYR D 2 117 ? 28.53748 8.01538   -13.77625 1.000 54.66601  ? 449 TYR D OH  1 
ATOM   3158 N N   . ASN D 2 118 ? 28.56553 13.48965  -6.89174  1.000 52.63151  ? 450 ASN D N   1 
ATOM   3159 C CA  . ASN D 2 118 ? 28.80897 14.58112  -5.95506  1.000 55.65581  ? 450 ASN D CA  1 
ATOM   3160 C C   . ASN D 2 118 ? 29.88435 14.23812  -4.93151  1.000 48.74802  ? 450 ASN D C   1 
ATOM   3161 O O   . ASN D 2 118 ? 30.53429 15.14465  -4.40000  1.000 52.28640  ? 450 ASN D O   1 
ATOM   3162 C CB  . ASN D 2 118 ? 27.51252 14.96001  -5.23552  1.000 55.64756  ? 450 ASN D CB  1 
ATOM   3163 C CG  . ASN D 2 118 ? 26.46390 15.51734  -6.17744  1.000 55.54924  ? 450 ASN D CG  1 
ATOM   3164 O OD1 . ASN D 2 118 ? 26.78070 15.98690  -7.26980  1.000 54.10464  ? 450 ASN D OD1 1 
ATOM   3165 N ND2 . ASN D 2 118 ? 25.20540 15.47282  -5.75458  1.000 60.14363  ? 450 ASN D ND2 1 
ATOM   3166 N N   . TYR D 2 119 ? 30.08628 12.95548  -4.64139  1.000 44.52093  ? 451 TYR D N   1 
ATOM   3167 C CA  . TYR D 2 119 ? 31.07337 12.53025  -3.65726  1.000 43.18267  ? 451 TYR D CA  1 
ATOM   3168 C C   . TYR D 2 119 ? 32.40727 12.25312  -4.33952  1.000 48.80685  ? 451 TYR D C   1 
ATOM   3169 O O   . TYR D 2 119 ? 32.45716 11.56859  -5.36724  1.000 47.96493  ? 451 TYR D O   1 
ATOM   3170 C CB  . TYR D 2 119 ? 30.59090 11.28516  -2.91429  1.000 42.86778  ? 451 TYR D CB  1 
ATOM   3171 C CG  . TYR D 2 119 ? 29.35170 11.50782  -2.07682  1.000 48.57520  ? 451 TYR D CG  1 
ATOM   3172 C CD1 . TYR D 2 119 ? 29.44837 11.97730  -0.77186  1.000 45.87434  ? 451 TYR D CD1 1 
ATOM   3173 C CD2 . TYR D 2 119 ? 28.08631 11.24042  -2.58540  1.000 44.20716  ? 451 TYR D CD2 1 
ATOM   3174 C CE1 . TYR D 2 119 ? 28.32093 12.17971  0.00131   1.000 46.15306  ? 451 TYR D CE1 1 
ATOM   3175 C CE2 . TYR D 2 119 ? 26.95031 11.44100  -1.81852  1.000 43.88103  ? 451 TYR D CE2 1 
ATOM   3176 C CZ  . TYR D 2 119 ? 27.07529 11.90905  -0.52433  1.000 48.92375  ? 451 TYR D CZ  1 
ATOM   3177 O OH  . TYR D 2 119 ? 25.95511 12.11127  0.24912   1.000 46.56689  ? 451 TYR D OH  1 
ATOM   3178 N N   . LEU D 2 120 ? 33.48262 12.78095  -3.76310  1.000 46.55362  ? 452 LEU D N   1 
ATOM   3179 C CA  . LEU D 2 120 ? 34.82142 12.66238  -4.31953  1.000 45.91914  ? 452 LEU D CA  1 
ATOM   3180 C C   . LEU D 2 120 ? 35.74716 11.97065  -3.32663  1.000 43.87384  ? 452 LEU D C   1 
ATOM   3181 O O   . LEU D 2 120 ? 35.41988 11.78510  -2.15242  1.000 48.39997  ? 452 LEU D O   1 
ATOM   3182 C CB  . LEU D 2 120 ? 35.38652 14.03880  -4.69814  1.000 46.45787  ? 452 LEU D CB  1 
ATOM   3183 C CG  . LEU D 2 120 ? 35.23919 14.49097  -6.15450  1.000 54.39977  ? 452 LEU D CG  1 
ATOM   3184 C CD1 . LEU D 2 120 ? 33.77729 14.55467  -6.57265  1.000 54.57103  ? 452 LEU D CD1 1 
ATOM   3185 C CD2 . LEU D 2 120 ? 35.91987 15.83616  -6.36558  1.000 49.43836  ? 452 LEU D CD2 1 
ATOM   3186 N N   . TYR D 2 121 ? 36.92235 11.59024  -3.82051  1.000 44.15530  ? 453 TYR D N   1 
ATOM   3187 C CA  . TYR D 2 121 ? 37.94293 10.96093  -2.99629  1.000 44.55998  ? 453 TYR D CA  1 
ATOM   3188 C C   . TYR D 2 121 ? 39.30319 11.24502  -3.61303  1.000 43.33675  ? 453 TYR D C   1 
ATOM   3189 O O   . TYR D 2 121 ? 39.42025 11.48869  -4.81793  1.000 43.25018  ? 453 TYR D O   1 
ATOM   3190 C CB  . TYR D 2 121 ? 37.71411 9.44827   -2.86250  1.000 43.53878  ? 453 TYR D CB  1 
ATOM   3191 C CG  . TYR D 2 121 ? 37.74511 8.70249   -4.18023  1.000 43.68883  ? 453 TYR D CG  1 
ATOM   3192 C CD1 . TYR D 2 121 ? 36.59442 8.55136   -4.94251  1.000 43.59535  ? 453 TYR D CD1 1 
ATOM   3193 C CD2 . TYR D 2 121 ? 38.92528 8.14840   -4.65990  1.000 44.74247  ? 453 TYR D CD2 1 
ATOM   3194 C CE1 . TYR D 2 121 ? 36.61815 7.87151   -6.14500  1.000 42.36018  ? 453 TYR D CE1 1 
ATOM   3195 C CE2 . TYR D 2 121 ? 38.95961 7.46908   -5.86273  1.000 44.37374  ? 453 TYR D CE2 1 
ATOM   3196 C CZ  . TYR D 2 121 ? 37.80406 7.33260   -6.60059  1.000 45.78156  ? 453 TYR D CZ  1 
ATOM   3197 O OH  . TYR D 2 121 ? 37.83511 6.65459   -7.79776  1.000 49.16516  ? 453 TYR D OH  1 
ATOM   3198 N N   . ARG D 2 122 ? 40.33469 11.21418  -2.77375  1.000 37.98991  ? 454 ARG D N   1 
ATOM   3199 C CA  . ARG D 2 122 ? 41.69715 11.44174  -3.23381  1.000 41.73754  ? 454 ARG D CA  1 
ATOM   3200 C C   . ARG D 2 122 ? 42.30315 10.13332  -3.72159  1.000 47.95103  ? 454 ARG D C   1 
ATOM   3201 O O   . ARG D 2 122 ? 42.29726 9.13003   -3.00016  1.000 41.24774  ? 454 ARG D O   1 
ATOM   3202 C CB  . ARG D 2 122 ? 42.56351 12.04101  -2.12811  1.000 42.43535  ? 454 ARG D CB  1 
ATOM   3203 C CG  . ARG D 2 122 ? 43.99165 12.33107  -2.57319  1.000 41.35902  ? 454 ARG D CG  1 
ATOM   3204 C CD  . ARG D 2 122 ? 44.71549 13.23251  -1.58617  1.000 41.73901  ? 454 ARG D CD  1 
ATOM   3205 N NE  . ARG D 2 122 ? 43.93943 14.43144  -1.29117  1.000 44.00119  ? 454 ARG D NE  1 
ATOM   3206 C CZ  . ARG D 2 122 ? 44.00982 15.56335  -1.97851  1.000 45.70983  ? 454 ARG D CZ  1 
ATOM   3207 N NH1 . ARG D 2 122 ? 44.83584 15.70099  -3.00374  1.000 49.99113  ? 454 ARG D NH1 1 
ATOM   3208 N NH2 . ARG D 2 122 ? 43.22921 16.58215  -1.63040  1.000 45.14872  ? 454 ARG D NH2 1 
ATOM   3209 N N   . LEU D 2 123 ? 42.82593 10.15221  -4.94742  1.000 43.50155  ? 455 LEU D N   1 
ATOM   3210 C CA  . LEU D 2 123 ? 43.44594 8.98127   -5.55070  1.000 41.01283  ? 455 LEU D CA  1 
ATOM   3211 C C   . LEU D 2 123 ? 44.96705 9.02484   -5.51555  1.000 45.79859  ? 455 LEU D C   1 
ATOM   3212 O O   . LEU D 2 123 ? 45.60440 7.96948   -5.43699  1.000 47.38291  ? 455 LEU D O   1 
ATOM   3213 C CB  . LEU D 2 123 ? 42.97193 8.82857   -7.00158  1.000 40.00041  ? 455 LEU D CB  1 
ATOM   3214 C CG  . LEU D 2 123 ? 43.48564 7.63512   -7.80937  1.000 44.66787  ? 455 LEU D CG  1 
ATOM   3215 C CD1 . LEU D 2 123 ? 43.15150 6.32662   -7.11635  1.000 41.64898  ? 455 LEU D CD1 1 
ATOM   3216 C CD2 . LEU D 2 123 ? 42.90358 7.65888   -9.21506  1.000 46.78993  ? 455 LEU D CD2 1 
ATOM   3217 N N   . PHE D 2 124 ? 45.56359 10.21293  -5.55575  1.000 46.62397  ? 456 PHE D N   1 
ATOM   3218 C CA  . PHE D 2 124 ? 47.01044 10.36688  -5.57331  1.000 49.15780  ? 456 PHE D CA  1 
ATOM   3219 C C   . PHE D 2 124 ? 47.45586 11.26048  -4.42496  1.000 51.50404  ? 456 PHE D C   1 
ATOM   3220 O O   . PHE D 2 124 ? 46.80714 12.26683  -4.12172  1.000 43.22450  ? 456 PHE D O   1 
ATOM   3221 C CB  . PHE D 2 124 ? 47.49455 10.97537  -6.89200  1.000 47.96411  ? 456 PHE D CB  1 
ATOM   3222 C CG  . PHE D 2 124 ? 46.89579 10.34771  -8.11684  1.000 47.33248  ? 456 PHE D CG  1 
ATOM   3223 C CD1 . PHE D 2 124 ? 47.46814 9.22402   -8.68689  1.000 48.22003  ? 456 PHE D CD1 1 
ATOM   3224 C CD2 . PHE D 2 124 ? 45.77515 10.89948  -8.71433  1.000 47.28612  ? 456 PHE D CD2 1 
ATOM   3225 C CE1 . PHE D 2 124 ? 46.92415 8.65398   -9.82286  1.000 44.58503  ? 456 PHE D CE1 1 
ATOM   3226 C CE2 . PHE D 2 124 ? 45.22804 10.33414  -9.84980  1.000 48.52715  ? 456 PHE D CE2 1 
ATOM   3227 C CZ  . PHE D 2 124 ? 45.80391 9.21040   -10.40347 1.000 41.37124  ? 456 PHE D CZ  1 
ATOM   3228 N N   . ARG D 2 125 ? 48.57351 10.89402  -3.80078  1.000 49.05108  ? 457 ARG D N   1 
ATOM   3229 C CA  . ARG D 2 125 ? 49.21549 11.73988  -2.80529  1.000 53.18491  ? 457 ARG D CA  1 
ATOM   3230 C C   . ARG D 2 125 ? 50.65099 11.26735  -2.62905  1.000 55.42379  ? 457 ARG D C   1 
ATOM   3231 O O   . ARG D 2 125 ? 50.92395 10.06518  -2.68425  1.000 51.69940  ? 457 ARG D O   1 
ATOM   3232 C CB  . ARG D 2 125 ? 48.47039 11.71299  -1.46423  1.000 52.17606  ? 457 ARG D CB  1 
ATOM   3233 C CG  . ARG D 2 125 ? 48.79483 12.89568  -0.56331  1.000 47.85997  ? 457 ARG D CG  1 
ATOM   3234 C CD  . ARG D 2 125 ? 47.91067 12.92292  0.67117   1.000 49.46880  ? 457 ARG D CD  1 
ATOM   3235 N NE  . ARG D 2 125 ? 48.01333 14.19274  1.38188   1.000 54.54753  ? 457 ARG D NE  1 
ATOM   3236 C CZ  . ARG D 2 125 ? 48.84080 14.42604  2.39225   1.000 53.17173  ? 457 ARG D CZ  1 
ATOM   3237 N NH1 . ARG D 2 125 ? 49.65136 13.48785  2.85397   1.000 48.51276  ? 457 ARG D NH1 1 
ATOM   3238 N NH2 . ARG D 2 125 ? 48.84864 15.62889  2.95943   1.000 51.40917  ? 457 ARG D NH2 1 
ATOM   3239 N N   . LYS D 2 126 ? 51.56254 12.22279  -2.42564  1.000 55.91722  ? 458 LYS D N   1 
ATOM   3240 C CA  . LYS D 2 126 ? 52.97651 11.88128  -2.30473  1.000 57.02049  ? 458 LYS D CA  1 
ATOM   3241 C C   . LYS D 2 126 ? 53.25740 11.05436  -1.05719  1.000 60.98605  ? 458 LYS D C   1 
ATOM   3242 O O   . LYS D 2 126 ? 54.12983 10.17904  -1.08034  1.000 65.50902  ? 458 LYS D O   1 
ATOM   3243 C CB  . LYS D 2 126 ? 53.82892 13.15081  -2.30050  1.000 54.16756  ? 458 LYS D CB  1 
ATOM   3244 C CG  . LYS D 2 126 ? 54.07220 13.74668  -3.67965  1.000 65.24095  ? 458 LYS D CG  1 
ATOM   3245 C CD  . LYS D 2 126 ? 54.77273 12.75027  -4.59560  1.000 64.14121  ? 458 LYS D CD  1 
ATOM   3246 C CE  . LYS D 2 126 ? 55.25424 13.41347  -5.87920  1.000 62.45349  ? 458 LYS D CE  1 
ATOM   3247 N NZ  . LYS D 2 126 ? 54.14350 14.04929  -6.64152  1.000 56.19085  ? 458 LYS D NZ  1 
ATOM   3248 N N   . SER D 2 127 ? 52.53785 11.30982  0.03210   1.000 62.03508  ? 459 SER D N   1 
ATOM   3249 C CA  . SER D 2 127 ? 52.73199 10.57927  1.27403   1.000 63.21803  ? 459 SER D CA  1 
ATOM   3250 C C   . SER D 2 127 ? 51.37425 10.21314  1.85503   1.000 61.47456  ? 459 SER D C   1 
ATOM   3251 O O   . SER D 2 127 ? 50.33123 10.71517  1.42645   1.000 61.93406  ? 459 SER D O   1 
ATOM   3252 C CB  . SER D 2 127 ? 53.55166 11.39361  2.28291   1.000 58.48019  ? 459 SER D CB  1 
ATOM   3253 O OG  . SER D 2 127 ? 52.91852 12.62707  2.57199   1.000 64.52060  ? 459 SER D OG  1 
ATOM   3254 N N   . ASN D 2 128 ? 51.39757 9.32202   2.84074   1.000 60.54910  ? 460 ASN D N   1 
ATOM   3255 C CA  . ASN D 2 128 ? 50.17633 8.90232   3.50763   1.000 60.40161  ? 460 ASN D CA  1 
ATOM   3256 C C   . ASN D 2 128 ? 49.72446 9.95590   4.51066   1.000 60.80666  ? 460 ASN D C   1 
ATOM   3257 O O   . ASN D 2 128 ? 50.53267 10.70447  5.06792   1.000 64.55674  ? 460 ASN D O   1 
ATOM   3258 C CB  . ASN D 2 128 ? 50.38100 7.56298   4.21528   1.000 53.58386  ? 460 ASN D CB  1 
ATOM   3259 C CG  . ASN D 2 128 ? 50.68053 6.43607   3.25002   1.000 53.08016  ? 460 ASN D CG  1 
ATOM   3260 O OD1 . ASN D 2 128 ? 50.27288 6.47315   2.08953   1.000 56.48642  ? 460 ASN D OD1 1 
ATOM   3261 N ND2 . ASN D 2 128 ? 51.39612 5.42429   3.72558   1.000 54.82073  ? 460 ASN D ND2 1 
ATOM   3262 N N   . LEU D 2 129 ? 48.41498 10.01075  4.73343   1.000 56.70169  ? 461 LEU D N   1 
ATOM   3263 C CA  . LEU D 2 129 ? 47.86660 10.95279  5.69670   1.000 57.42803  ? 461 LEU D CA  1 
ATOM   3264 C C   . LEU D 2 129 ? 48.19889 10.52366  7.11862   1.000 58.79002  ? 461 LEU D C   1 
ATOM   3265 O O   . LEU D 2 129 ? 48.08560 9.34787   7.47637   1.000 61.13726  ? 461 LEU D O   1 
ATOM   3266 C CB  . LEU D 2 129 ? 46.35120 11.07096  5.53351   1.000 54.74624  ? 461 LEU D CB  1 
ATOM   3267 C CG  . LEU D 2 129 ? 45.82943 11.95840  4.40398   1.000 49.48616  ? 461 LEU D CG  1 
ATOM   3268 C CD1 . LEU D 2 129 ? 44.32385 12.07135  4.49221   1.000 43.68540  ? 461 LEU D CD1 1 
ATOM   3269 C CD2 . LEU D 2 129 ? 46.45997 13.33044  4.47421   1.000 48.17053  ? 461 LEU D CD2 1 
ATOM   3270 N N   . LYS D 2 130 ? 48.61864 11.48907  7.92911   1.000 61.26923  ? 462 LYS D N   1 
ATOM   3271 C CA  . LYS D 2 130 ? 48.75986 11.25695  9.35122   1.000 63.13646  ? 462 LYS D CA  1 
ATOM   3272 C C   . LYS D 2 130 ? 47.37464 11.16312  9.98926   1.000 58.30624  ? 462 LYS D C   1 
ATOM   3273 O O   . LYS D 2 130 ? 46.37840 11.57208  9.38641   1.000 54.29184  ? 462 LYS D O   1 
ATOM   3274 C CB  . LYS D 2 130 ? 49.58926 12.37181  9.98706   1.000 62.36982  ? 462 LYS D CB  1 
ATOM   3275 C CG  . LYS D 2 130 ? 51.08894 12.18567  9.80084   1.000 67.94835  ? 462 LYS D CG  1 
ATOM   3276 C CD  . LYS D 2 130 ? 51.88105 13.37329  10.32171  1.000 79.11018  ? 462 LYS D CD  1 
ATOM   3277 C CE  . LYS D 2 130 ? 51.68586 14.59656  9.44024   1.000 79.78666  ? 462 LYS D CE  1 
ATOM   3278 N NZ  . LYS D 2 130 ? 52.55955 15.72870  9.85865   1.000 82.38821  ? 462 LYS D NZ  1 
ATOM   3279 N N   . PRO D 2 131 ? 47.28105 10.59498  11.19199  1.000 55.25129  ? 463 PRO D N   1 
ATOM   3280 C CA  . PRO D 2 131 ? 45.96986 10.43561  11.83172  1.000 48.51433  ? 463 PRO D CA  1 
ATOM   3281 C C   . PRO D 2 131 ? 45.20901 11.74903  11.93220  1.000 51.06954  ? 463 PRO D C   1 
ATOM   3282 O O   . PRO D 2 131 ? 45.74363 12.76801  12.37642  1.000 52.53957  ? 463 PRO D O   1 
ATOM   3283 C CB  . PRO D 2 131 ? 46.32620 9.88133   13.21183  1.000 55.18740  ? 463 PRO D CB  1 
ATOM   3284 C CG  . PRO D 2 131 ? 47.56112 9.09977   12.96842  1.000 54.42107  ? 463 PRO D CG  1 
ATOM   3285 C CD  . PRO D 2 131 ? 48.33398 9.87402   11.93128  1.000 53.00248  ? 463 PRO D CD  1 
ATOM   3286 N N   . PHE D 2 132 ? 43.95285 11.71836  11.48387  1.000 47.75718  ? 464 PHE D N   1 
ATOM   3287 C CA  . PHE D 2 132 ? 43.01932 12.83944  11.57578  1.000 46.14163  ? 464 PHE D CA  1 
ATOM   3288 C C   . PHE D 2 132 ? 43.44521 14.03342  10.73145  1.000 45.49590  ? 464 PHE D C   1 
ATOM   3289 O O   . PHE D 2 132 ? 42.90453 15.13181  10.89034  1.000 46.88324  ? 464 PHE D O   1 
ATOM   3290 C CB  . PHE D 2 132 ? 42.81017 13.26683  13.03387  1.000 46.04636  ? 464 PHE D CB  1 
ATOM   3291 C CG  . PHE D 2 132 ? 42.03495 12.27033  13.84672  1.000 45.82801  ? 464 PHE D CG  1 
ATOM   3292 C CD1 . PHE D 2 132 ? 40.97492 11.57790  13.28416  1.000 44.16509  ? 464 PHE D CD1 1 
ATOM   3293 C CD2 . PHE D 2 132 ? 42.36852 12.01830  15.16607  1.000 49.14571  ? 464 PHE D CD2 1 
ATOM   3294 C CE1 . PHE D 2 132 ? 40.25861 10.65770  14.02348  1.000 49.04974  ? 464 PHE D CE1 1 
ATOM   3295 C CE2 . PHE D 2 132 ? 41.65625 11.09883  15.91217  1.000 49.41105  ? 464 PHE D CE2 1 
ATOM   3296 C CZ  . PHE D 2 132 ? 40.59935 10.41768  15.34153  1.000 46.28218  ? 464 PHE D CZ  1 
ATOM   3297 N N   . GLU D 2 133 ? 44.40349 13.84478  9.83017   1.000 50.14426  ? 465 GLU D N   1 
ATOM   3298 C CA  . GLU D 2 133 ? 44.77887 14.89981  8.90147   1.000 51.05354  ? 465 GLU D CA  1 
ATOM   3299 C C   . GLU D 2 133 ? 43.71330 15.04155  7.82224   1.000 48.16772  ? 465 GLU D C   1 
ATOM   3300 O O   . GLU D 2 133 ? 43.09544 14.05691  7.40464   1.000 45.71553  ? 465 GLU D O   1 
ATOM   3301 C CB  . GLU D 2 133 ? 46.13645 14.60139  8.26436   1.000 51.19813  ? 465 GLU D CB  1 
ATOM   3302 C CG  . GLU D 2 133 ? 46.66054 15.72081  7.38317   1.000 53.10114  ? 465 GLU D CG  1 
ATOM   3303 C CD  . GLU D 2 133 ? 48.00063 15.39833  6.75529   1.000 61.73240  ? 465 GLU D CD  1 
ATOM   3304 O OE1 . GLU D 2 133 ? 48.50779 14.27633  6.97035   1.000 63.08480  ? 465 GLU D OE1 1 
ATOM   3305 O OE2 . GLU D 2 133 ? 48.54548 16.26908  6.04405   1.000 66.62303  ? 465 GLU D OE2 1 
ATOM   3306 N N   . ARG D 2 134 ? 43.49606 16.27582  7.37377   1.000 46.17916  ? 466 ARG D N   1 
ATOM   3307 C CA  . ARG D 2 134 ? 42.49609 16.57663  6.35371   1.000 48.58215  ? 466 ARG D CA  1 
ATOM   3308 C C   . ARG D 2 134 ? 43.16323 17.36306  5.23226   1.000 45.97751  ? 466 ARG D C   1 
ATOM   3309 O O   . ARG D 2 134 ? 43.52613 18.52895  5.41796   1.000 50.44117  ? 466 ARG D O   1 
ATOM   3310 C CB  . ARG D 2 134 ? 41.32156 17.35181  6.95206   1.000 42.89103  ? 466 ARG D CB  1 
ATOM   3311 C CG  . ARG D 2 134 ? 40.27067 17.76259  5.93934   1.000 40.60006  ? 466 ARG D CG  1 
ATOM   3312 C CD  . ARG D 2 134 ? 39.02579 18.28144  6.62907   1.000 38.23736  ? 466 ARG D CD  1 
ATOM   3313 N NE  . ARG D 2 134 ? 38.14552 18.98627  5.70592   1.000 42.66396  ? 466 ARG D NE  1 
ATOM   3314 C CZ  . ARG D 2 134 ? 36.94111 19.44091  6.02246   1.000 46.14528  ? 466 ARG D CZ  1 
ATOM   3315 N NH1 . ARG D 2 134 ? 36.43550 19.27123  7.23367   1.000 51.03635  ? 466 ARG D NH1 1 
ATOM   3316 N NH2 . ARG D 2 134 ? 36.22403 20.07744  5.10070   1.000 42.08205  ? 466 ARG D NH2 1 
ATOM   3317 N N   . ASP D 2 135 ? 43.32784 16.72501  4.07518   1.000 51.42261  ? 467 ASP D N   1 
ATOM   3318 C CA  . ASP D 2 135 ? 43.94909 17.33498  2.90406   1.000 49.38141  ? 467 ASP D CA  1 
ATOM   3319 C C   . ASP D 2 135 ? 42.87598 17.58364  1.85195   1.000 47.12103  ? 467 ASP D C   1 
ATOM   3320 O O   . ASP D 2 135 ? 42.28313 16.63339  1.33141   1.000 49.13236  ? 467 ASP D O   1 
ATOM   3321 C CB  . ASP D 2 135 ? 45.05670 16.43836  2.34626   1.000 46.22477  ? 467 ASP D CB  1 
ATOM   3322 C CG  . ASP D 2 135 ? 45.83518 17.09201  1.21390   1.000 49.74782  ? 467 ASP D CG  1 
ATOM   3323 O OD1 . ASP D 2 135 ? 45.52286 18.24315  0.84339   1.000 53.35863  ? 467 ASP D OD1 1 
ATOM   3324 O OD2 . ASP D 2 135 ? 46.76982 16.44813  0.69290   1.000 47.60364  ? 467 ASP D OD2 1 
ATOM   3325 N N   . ILE D 2 136 ? 42.63213 18.85571  1.54133   1.000 48.21460  ? 468 ILE D N   1 
ATOM   3326 C CA  . ILE D 2 136 ? 41.66873 19.24856  0.52242   1.000 49.05238  ? 468 ILE D CA  1 
ATOM   3327 C C   . ILE D 2 136 ? 42.33927 20.03204  -0.60369  1.000 52.51720  ? 468 ILE D C   1 
ATOM   3328 O O   . ILE D 2 136 ? 41.68061 20.77916  -1.32071  1.000 52.25218  ? 468 ILE D O   1 
ATOM   3329 C CB  . ILE D 2 136 ? 40.50330 20.04899  1.13359   1.000 49.42317  ? 468 ILE D CB  1 
ATOM   3330 C CG1 . ILE D 2 136 ? 41.02209 21.32982  1.78728   1.000 48.42690  ? 468 ILE D CG1 1 
ATOM   3331 C CG2 . ILE D 2 136 ? 39.73748 19.19905  2.13486   1.000 47.35355  ? 468 ILE D CG2 1 
ATOM   3332 C CD1 . ILE D 2 136 ? 39.92476 22.25685  2.24339   1.000 52.09110  ? 468 ILE D CD1 1 
ATOM   3333 N N   . SER D 2 137 ? 43.64906 19.87157  -0.76296  1.000 52.72613  ? 469 SER D N   1 
ATOM   3334 C CA  . SER D 2 137 ? 44.35746 20.56819  -1.82526  1.000 51.85862  ? 469 SER D CA  1 
ATOM   3335 C C   . SER D 2 137 ? 44.05488 19.93091  -3.17582  1.000 53.63424  ? 469 SER D C   1 
ATOM   3336 O O   . SER D 2 137 ? 43.91368 18.70985  -3.28990  1.000 51.48953  ? 469 SER D O   1 
ATOM   3337 C CB  . SER D 2 137 ? 45.86226 20.55108  -1.56032  1.000 52.92900  ? 469 SER D CB  1 
ATOM   3338 O OG  . SER D 2 137 ? 46.37922 19.23297  -1.62937  1.000 58.78035  ? 469 SER D OG  1 
ATOM   3339 N N   . THR D 2 138 ? 43.95515 20.77007  -4.20340  1.000 56.11839  ? 470 THR D N   1 
ATOM   3340 C CA  . THR D 2 138 ? 43.70587 20.33308  -5.57198  1.000 47.41430  ? 470 THR D CA  1 
ATOM   3341 C C   . THR D 2 138 ? 44.95852 20.48443  -6.43088  1.000 50.93161  ? 470 THR D C   1 
ATOM   3342 O O   . THR D 2 138 ? 44.89871 20.92392  -7.58067  1.000 51.41854  ? 470 THR D O   1 
ATOM   3343 C CB  . THR D 2 138 ? 42.53996 21.10489  -6.18269  1.000 46.99622  ? 470 THR D CB  1 
ATOM   3344 O OG1 . THR D 2 138 ? 42.83087 22.50709  -6.15904  1.000 52.43635  ? 470 THR D OG1 1 
ATOM   3345 C CG2 . THR D 2 138 ? 41.25870 20.84407  -5.39987  1.000 45.37393  ? 470 THR D CG2 1 
ATOM   3346 N N   . GLU D 2 139 ? 46.10847 20.11801  -5.87204  1.000 55.05684  ? 471 GLU D N   1 
ATOM   3347 C CA  . GLU D 2 139 ? 47.37847 20.25465  -6.56913  1.000 50.68784  ? 471 GLU D CA  1 
ATOM   3348 C C   . GLU D 2 139 ? 47.55973 19.10811  -7.55521  1.000 62.47908  ? 471 GLU D C   1 
ATOM   3349 O O   . GLU D 2 139 ? 47.34749 17.94184  -7.20867  1.000 60.91801  ? 471 GLU D O   1 
ATOM   3350 C CB  . GLU D 2 139 ? 48.53313 20.27330  -5.56863  1.000 59.78667  ? 471 GLU D CB  1 
ATOM   3351 C CG  . GLU D 2 139 ? 49.73826 21.06899  -6.02788  1.000 60.31891  ? 471 GLU D CG  1 
ATOM   3352 C CD  . GLU D 2 139 ? 49.49597 22.56237  -5.95994  1.000 72.47183  ? 471 GLU D CD  1 
ATOM   3353 O OE1 . GLU D 2 139 ? 48.77154 23.00350  -5.04284  1.000 69.14865  ? 471 GLU D OE1 1 
ATOM   3354 O OE2 . GLU D 2 139 ? 50.02201 23.29366  -6.82558  1.000 81.40218  ? 471 GLU D OE2 1 
ATOM   3355 N N   . ILE D 2 140 ? 47.95869 19.44233  -8.78488  1.000 54.85837  ? 472 ILE D N   1 
ATOM   3356 C CA  . ILE D 2 140 ? 48.20974 18.41749  -9.79018  1.000 57.34092  ? 472 ILE D CA  1 
ATOM   3357 C C   . ILE D 2 140 ? 49.32901 17.50739  -9.30771  1.000 56.63949  ? 472 ILE D C   1 
ATOM   3358 O O   . ILE D 2 140 ? 50.37646 17.97295  -8.84061  1.000 55.61468  ? 472 ILE D O   1 
ATOM   3359 C CB  . ILE D 2 140 ? 48.53899 19.06413  -11.14546 1.000 59.67423  ? 472 ILE D CB  1 
ATOM   3360 C CG1 . ILE D 2 140 ? 47.25827 19.33381  -11.94300 1.000 58.95829  ? 472 ILE D CG1 1 
ATOM   3361 C CG2 . ILE D 2 140 ? 49.48627 18.18472  -11.95314 1.000 57.49253  ? 472 ILE D CG2 1 
ATOM   3362 C CD1 . ILE D 2 140 ? 46.34431 20.38246  -11.34146 1.000 64.37237  ? 472 ILE D CD1 1 
ATOM   3363 N N   . TYR D 2 141 ? 49.10388 16.19954  -9.40471  1.000 57.64864  ? 473 TYR D N   1 
ATOM   3364 C CA  . TYR D 2 141 ? 50.03798 15.21124  -8.88640  1.000 54.43254  ? 473 TYR D CA  1 
ATOM   3365 C C   . TYR D 2 141 ? 51.05139 14.81569  -9.95166  1.000 53.76624  ? 473 TYR D C   1 
ATOM   3366 O O   . TYR D 2 141 ? 50.70073 14.60791  -11.11566 1.000 58.77066  ? 473 TYR D O   1 
ATOM   3367 C CB  . TYR D 2 141 ? 49.28620 13.97313  -8.39548  1.000 51.42384  ? 473 TYR D CB  1 
ATOM   3368 C CG  . TYR D 2 141 ? 50.16794 12.93914  -7.73522  1.000 50.95201  ? 473 TYR D CG  1 
ATOM   3369 C CD1 . TYR D 2 141 ? 50.56552 13.08151  -6.41306  1.000 50.21349  ? 473 TYR D CD1 1 
ATOM   3370 C CD2 . TYR D 2 141 ? 50.59528 11.81541  -8.43064  1.000 52.67991  ? 473 TYR D CD2 1 
ATOM   3371 C CE1 . TYR D 2 141 ? 51.37055 12.13794  -5.80298  1.000 52.54825  ? 473 TYR D CE1 1 
ATOM   3372 C CE2 . TYR D 2 141 ? 51.40051 10.86635  -7.82883  1.000 52.77077  ? 473 TYR D CE2 1 
ATOM   3373 C CZ  . TYR D 2 141 ? 51.78394 11.03262  -6.51456  1.000 54.41028  ? 473 TYR D CZ  1 
ATOM   3374 O OH  . TYR D 2 141 ? 52.58423 10.09058  -5.91069  1.000 56.64626  ? 473 TYR D OH  1 
ATOM   3375 N N   . GLN D 2 142 ? 52.31185 14.70973  -9.54301  1.000 54.45707  ? 474 GLN D N   1 
ATOM   3376 C CA  . GLN D 2 142 ? 53.39800 14.28351  -10.42311 1.000 55.01223  ? 474 GLN D CA  1 
ATOM   3377 C C   . GLN D 2 142 ? 53.59712 12.78488  -10.22579 1.000 54.81719  ? 474 GLN D C   1 
ATOM   3378 O O   . GLN D 2 142 ? 54.28567 12.35558  -9.29639  1.000 59.81209  ? 474 GLN D O   1 
ATOM   3379 C CB  . GLN D 2 142 ? 54.67474 15.06346  -10.12935 1.000 55.43212  ? 474 GLN D CB  1 
ATOM   3380 C CG  . GLN D 2 142 ? 55.84014 14.69648  -11.02763 1.000 60.97081  ? 474 GLN D CG  1 
ATOM   3381 C CD  . GLN D 2 142 ? 57.09778 15.47932  -10.70812 1.000 65.86071  ? 474 GLN D CD  1 
ATOM   3382 O OE1 . GLN D 2 142 ? 57.23396 16.04346  -9.62281  1.000 71.36113  ? 474 GLN D OE1 1 
ATOM   3383 N NE2 . GLN D 2 142 ? 58.02505 15.52010  -11.65702 1.000 67.71315  ? 474 GLN D NE2 1 
ATOM   3384 N N   . ALA D 2 143 ? 52.98937 11.98812  -11.10553 1.000 54.25068  ? 475 ALA D N   1 
ATOM   3385 C CA  . ALA D 2 143 ? 53.02785 10.53753  -10.97631 1.000 55.92907  ? 475 ALA D CA  1 
ATOM   3386 C C   . ALA D 2 143 ? 54.28282 9.90977   -11.56957 1.000 59.27616  ? 475 ALA D C   1 
ATOM   3387 O O   . ALA D 2 143 ? 54.49187 8.70441   -11.39382 1.000 56.71497  ? 475 ALA D O   1 
ATOM   3388 C CB  . ALA D 2 143 ? 51.78956 9.92328   -11.63107 1.000 58.00319  ? 475 ALA D CB  1 
ATOM   3389 N N   . GLY D 2 144 ? 55.11547 10.68191  -12.26147 1.000 57.40326  ? 476 GLY D N   1 
ATOM   3390 C CA  . GLY D 2 144 ? 56.32786 10.14059  -12.84173 1.000 60.89772  ? 476 GLY D CA  1 
ATOM   3391 C C   . GLY D 2 144 ? 57.47026 11.13338  -12.86546 1.000 69.03218  ? 476 GLY D C   1 
ATOM   3392 O O   . GLY D 2 144 ? 57.45431 12.12615  -12.13192 1.000 66.99171  ? 476 GLY D O   1 
ATOM   3393 N N   . SER D 2 145 ? 58.47431 10.87432  -13.70291 1.000 74.21354  ? 477 SER D N   1 
ATOM   3394 C CA  . SER D 2 145 ? 59.59269 11.79603  -13.84549 1.000 72.92189  ? 477 SER D CA  1 
ATOM   3395 C C   . SER D 2 145 ? 59.24849 13.01302  -14.69212 1.000 76.29220  ? 477 SER D C   1 
ATOM   3396 O O   . SER D 2 145 ? 60.03766 13.96333  -14.72998 1.000 78.76795  ? 477 SER D O   1 
ATOM   3397 C CB  . SER D 2 145 ? 60.79880 11.07489  -14.45246 1.000 73.01116  ? 477 SER D CB  1 
ATOM   3398 O OG  . SER D 2 145 ? 60.50761 10.60375  -15.75587 1.000 71.31917  ? 477 SER D OG  1 
ATOM   3399 N N   . THR D 2 146 ? 58.10693 13.00842  -15.36499 1.000 70.29738  ? 478 THR D N   1 
ATOM   3400 C CA  . THR D 2 146 ? 57.70285 14.15591  -16.16715 1.000 74.21794  ? 478 THR D CA  1 
ATOM   3401 C C   . THR D 2 146 ? 57.30564 15.30779  -15.25419 1.000 73.87541  ? 478 THR D C   1 
ATOM   3402 O O   . THR D 2 146 ? 56.42437 15.13443  -14.40155 1.000 73.23968  ? 478 THR D O   1 
ATOM   3403 C CB  . THR D 2 146 ? 56.54216 13.78836  -17.08727 1.000 72.60401  ? 478 THR D CB  1 
ATOM   3404 O OG1 . THR D 2 146 ? 56.96211 12.77455  -18.00837 1.000 77.27414  ? 478 THR D OG1 1 
ATOM   3405 C CG2 . THR D 2 146 ? 56.07404 15.00907  -17.86460 1.000 64.98349  ? 478 THR D CG2 1 
ATOM   3406 N N   . PRO D 2 147 ? 57.92187 16.48117  -15.38233 1.000 79.34113  ? 479 PRO D N   1 
ATOM   3407 C CA  . PRO D 2 147 ? 57.52467 17.61511  -14.54005 1.000 72.88655  ? 479 PRO D CA  1 
ATOM   3408 C C   . PRO D 2 147 ? 56.14344 18.12388  -14.92022 1.000 69.57682  ? 479 PRO D C   1 
ATOM   3409 O O   . PRO D 2 147 ? 55.77783 18.16806  -16.09746 1.000 67.12933  ? 479 PRO D O   1 
ATOM   3410 C CB  . PRO D 2 147 ? 58.60503 18.66769  -14.82236 1.000 66.86241  ? 479 PRO D CB  1 
ATOM   3411 C CG  . PRO D 2 147 ? 59.73286 17.91324  -15.47796 1.000 73.21857  ? 479 PRO D CG  1 
ATOM   3412 C CD  . PRO D 2 147 ? 59.08069 16.80084  -16.23006 1.000 81.30637  ? 479 PRO D CD  1 
ATOM   3413 N N   . CYS D 2 148 ? 55.37538 18.50909  -13.90718 1.000 70.71493  ? 480 CYS D N   1 
ATOM   3414 C CA  . CYS D 2 148 ? 54.02597 19.01471  -14.10261 1.000 71.13326  ? 480 CYS D CA  1 
ATOM   3415 C C   . CYS D 2 148 ? 54.00768 20.53338  -13.98598 1.000 66.21881  ? 480 CYS D C   1 
ATOM   3416 O O   . CYS D 2 148 ? 54.76949 21.12647  -13.21925 1.000 60.43724  ? 480 CYS D O   1 
ATOM   3417 C CB  . CYS D 2 148 ? 53.05941 18.39751  -13.08998 1.000 63.85589  ? 480 CYS D CB  1 
ATOM   3418 S SG  . CYS D 2 148 ? 53.08187 16.58862  -13.06829 1.000 76.98706  ? 480 CYS D SG  1 
ATOM   3419 N N   . ASN D 2 149 ? 53.12789 21.15851  -14.76203 1.000 68.74504  ? 481 ASN D N   1 
ATOM   3420 C CA  . ASN D 2 149 ? 53.01574 22.61124  -14.82875 1.000 62.89671  ? 481 ASN D CA  1 
ATOM   3421 C C   . ASN D 2 149 ? 51.58197 23.04328  -14.55131 1.000 66.04290  ? 481 ASN D C   1 
ATOM   3422 O O   . ASN D 2 149 ? 50.96703 23.78784  -15.31723 1.000 70.20800  ? 481 ASN D O   1 
ATOM   3423 C CB  . ASN D 2 149 ? 53.49092 23.12141  -16.18677 1.000 67.27451  ? 481 ASN D CB  1 
ATOM   3424 C CG  . ASN D 2 149 ? 53.77348 24.61433  -16.18918 1.000 67.69570  ? 481 ASN D CG  1 
ATOM   3425 O OD1 . ASN D 2 149 ? 53.82181 25.25564  -15.13747 1.000 64.59232  ? 481 ASN D OD1 1 
ATOM   3426 N ND2 . ASN D 2 149 ? 53.97151 25.17311  -17.37771 1.000 65.73214  ? 481 ASN D ND2 1 
ATOM   3427 N N   . GLY D 2 150 ? 51.02683 22.56334  -13.44021 1.000 64.59367  ? 482 GLY D N   1 
ATOM   3428 C CA  . GLY D 2 150 ? 49.69895 22.97314  -13.02050 1.000 66.08201  ? 482 GLY D CA  1 
ATOM   3429 C C   . GLY D 2 150 ? 48.58104 22.59475  -13.96314 1.000 65.12338  ? 482 GLY D C   1 
ATOM   3430 O O   . GLY D 2 150 ? 47.50346 23.19219  -13.90320 1.000 70.47393  ? 482 GLY D O   1 
ATOM   3431 N N   . VAL D 2 151 ? 48.80230 21.61503  -14.83647 1.000 63.85959  ? 483 VAL D N   1 
ATOM   3432 C CA  . VAL D 2 151 ? 47.78907 21.16824  -15.78213 1.000 60.55514  ? 483 VAL D CA  1 
ATOM   3433 C C   . VAL D 2 151 ? 47.89289 19.65491  -15.91657 1.000 59.43733  ? 483 VAL D C   1 
ATOM   3434 O O   . VAL D 2 151 ? 48.95737 19.06552  -15.70549 1.000 59.59919  ? 483 VAL D O   1 
ATOM   3435 C CB  . VAL D 2 151 ? 47.94002 21.87017  -17.15336 1.000 65.14601  ? 483 VAL D CB  1 
ATOM   3436 C CG1 . VAL D 2 151 ? 49.16830 21.35488  -17.89634 1.000 68.14534  ? 483 VAL D CG1 1 
ATOM   3437 C CG2 . VAL D 2 151 ? 46.67814 21.70790  -17.98808 1.000 70.43911  ? 483 VAL D CG2 1 
ATOM   3438 N N   . GLU D 2 152 ? 46.76952 19.02286  -16.25084 1.000 58.31964  ? 484 GLU D N   1 
ATOM   3439 C CA  . GLU D 2 152 ? 46.74207 17.57385  -16.39793 1.000 59.68797  ? 484 GLU D CA  1 
ATOM   3440 C C   . GLU D 2 152 ? 47.46259 17.14854  -17.67149 1.000 53.57281  ? 484 GLU D C   1 
ATOM   3441 O O   . GLU D 2 152 ? 47.21808 17.69677  -18.75013 1.000 56.96064  ? 484 GLU D O   1 
ATOM   3442 C CB  . GLU D 2 152 ? 45.30165 17.06481  -16.40921 1.000 56.00856  ? 484 GLU D CB  1 
ATOM   3443 C CG  . GLU D 2 152 ? 44.71425 16.85513  -15.02518 1.000 54.90171  ? 484 GLU D CG  1 
ATOM   3444 C CD  . GLU D 2 152 ? 43.50268 15.94388  -15.03674 1.000 62.49039  ? 484 GLU D CD  1 
ATOM   3445 O OE1 . GLU D 2 152 ? 42.55318 16.22237  -15.80034 1.000 58.94913  ? 484 GLU D OE1 1 
ATOM   3446 O OE2 . GLU D 2 152 ? 43.50630 14.94170  -14.28801 1.000 54.29973  ? 484 GLU D OE2 1 
ATOM   3447 N N   . GLY D 2 153 ? 48.34697 16.17106  -17.54200 1.000 52.16259  ? 485 GLY D N   1 
ATOM   3448 C CA  . GLY D 2 153 ? 49.09236 15.66579  -18.66934 1.000 47.74359  ? 485 GLY D CA  1 
ATOM   3449 C C   . GLY D 2 153 ? 49.61730 14.27307  -18.40765 1.000 50.07869  ? 485 GLY D C   1 
ATOM   3450 O O   . GLY D 2 153 ? 49.06926 13.52488  -17.59723 1.000 52.50326  ? 485 GLY D O   1 
ATOM   3451 N N   . PHE D 2 154 ? 50.69477 13.92911  -19.11013 1.000 54.44892  ? 486 PHE D N   1 
ATOM   3452 C CA  . PHE D 2 154 ? 51.31315 12.61778  -18.95507 1.000 52.59370  ? 486 PHE D CA  1 
ATOM   3453 C C   . PHE D 2 154 ? 51.93379 12.50302  -17.56762 1.000 57.04549  ? 486 PHE D C   1 
ATOM   3454 O O   . PHE D 2 154 ? 52.83052 13.27710  -17.21479 1.000 57.31739  ? 486 PHE D O   1 
ATOM   3455 C CB  . PHE D 2 154 ? 52.36588 12.39662  -20.03905 1.000 51.67017  ? 486 PHE D CB  1 
ATOM   3456 C CG  . PHE D 2 154 ? 52.85085 10.97685  -20.13303 1.000 55.43225  ? 486 PHE D CG  1 
ATOM   3457 C CD1 . PHE D 2 154 ? 52.17400 10.05193  -20.90991 1.000 59.12262  ? 486 PHE D CD1 1 
ATOM   3458 C CD2 . PHE D 2 154 ? 53.98155 10.56619  -19.44612 1.000 57.12200  ? 486 PHE D CD2 1 
ATOM   3459 C CE1 . PHE D 2 154 ? 52.61512 8.74500   -20.99942 1.000 65.34584  ? 486 PHE D CE1 1 
ATOM   3460 C CE2 . PHE D 2 154 ? 54.42740 9.26016   -19.53319 1.000 57.17117  ? 486 PHE D CE2 1 
ATOM   3461 C CZ  . PHE D 2 154 ? 53.74290 8.34884   -20.30842 1.000 61.36672  ? 486 PHE D CZ  1 
ATOM   3462 N N   . ASN D 2 155 ? 51.45256 11.53747  -16.78307 1.000 56.75848  ? 487 ASN D N   1 
ATOM   3463 C CA  . ASN D 2 155 ? 51.83696 11.35471  -15.38369 1.000 58.49881  ? 487 ASN D CA  1 
ATOM   3464 C C   . ASN D 2 155 ? 51.57740 12.60307  -14.54458 1.000 58.38857  ? 487 ASN D C   1 
ATOM   3465 O O   . ASN D 2 155 ? 52.20408 12.79316  -13.49605 1.000 57.14606  ? 487 ASN D O   1 
ATOM   3466 C CB  . ASN D 2 155 ? 53.30352 10.92663  -15.25004 1.000 64.20698  ? 487 ASN D CB  1 
ATOM   3467 C CG  . ASN D 2 155 ? 53.61692 9.66170   -16.02307 1.000 63.24975  ? 487 ASN D CG  1 
ATOM   3468 O OD1 . ASN D 2 155 ? 54.73830 9.47572   -16.49350 1.000 68.06235  ? 487 ASN D OD1 1 
ATOM   3469 N ND2 . ASN D 2 155 ? 52.62522 8.78745   -16.16432 1.000 53.29873  ? 487 ASN D ND2 1 
ATOM   3470 N N   . CYS D 2 156 ? 50.66198 13.46007  -14.99426 1.000 55.31110  ? 488 CYS D N   1 
ATOM   3471 C CA  . CYS D 2 156 ? 50.24479 14.65082  -14.26087 1.000 56.80915  ? 488 CYS D CA  1 
ATOM   3472 C C   . CYS D 2 156 ? 48.72341 14.64210  -14.21543 1.000 58.74781  ? 488 CYS D C   1 
ATOM   3473 O O   . CYS D 2 156 ? 48.06779 14.93362  -15.22107 1.000 51.73531  ? 488 CYS D O   1 
ATOM   3474 C CB  . CYS D 2 156 ? 50.77432 15.92539  -14.92035 1.000 55.71623  ? 488 CYS D CB  1 
ATOM   3475 S SG  . CYS D 2 156 ? 52.57727 16.04141  -14.95985 1.000 58.90678  ? 488 CYS D SG  1 
ATOM   3476 N N   . TYR D 2 157 ? 48.15985 14.30580  -13.05750 1.000 53.84313  ? 489 TYR D N   1 
ATOM   3477 C CA  . TYR D 2 157 ? 46.72916 14.07200  -12.94581 1.000 56.80453  ? 489 TYR D CA  1 
ATOM   3478 C C   . TYR D 2 157 ? 46.13074 14.91073  -11.82851 1.000 53.30776  ? 489 TYR D C   1 
ATOM   3479 O O   . TYR D 2 157 ? 46.79906 15.23962  -10.84432 1.000 57.93418  ? 489 TYR D O   1 
ATOM   3480 C CB  . TYR D 2 157 ? 46.42342 12.59122  -12.68678 1.000 54.64421  ? 489 TYR D CB  1 
ATOM   3481 C CG  . TYR D 2 157 ? 47.20588 11.64313  -13.56526 1.000 57.09062  ? 489 TYR D CG  1 
ATOM   3482 C CD1 . TYR D 2 157 ? 47.00350 11.60918  -14.94046 1.000 52.91450  ? 489 TYR D CD1 1 
ATOM   3483 C CD2 . TYR D 2 157 ? 48.14457 10.77827  -13.01900 1.000 52.37102  ? 489 TYR D CD2 1 
ATOM   3484 C CE1 . TYR D 2 157 ? 47.71843 10.74059  -15.74648 1.000 49.62264  ? 489 TYR D CE1 1 
ATOM   3485 C CE2 . TYR D 2 157 ? 48.86227 9.90767   -13.81632 1.000 58.01841  ? 489 TYR D CE2 1 
ATOM   3486 C CZ  . TYR D 2 157 ? 48.64623 9.89295   -15.17734 1.000 51.00111  ? 489 TYR D CZ  1 
ATOM   3487 O OH  . TYR D 2 157 ? 49.36315 9.02446   -15.96451 1.000 53.67793  ? 489 TYR D OH  1 
ATOM   3488 N N   . PHE D 2 158 ? 44.86002 15.25298  -12.00001 1.000 52.43306  ? 490 PHE D N   1 
ATOM   3489 C CA  . PHE D 2 158 ? 44.09990 15.86127  -10.92262 1.000 48.44167  ? 490 PHE D CA  1 
ATOM   3490 C C   . PHE D 2 158 ? 44.00473 14.87014  -9.76660  1.000 50.58427  ? 490 PHE D C   1 
ATOM   3491 O O   . PHE D 2 158 ? 43.67804 13.69569  -9.98983  1.000 50.00510  ? 490 PHE D O   1 
ATOM   3492 C CB  . PHE D 2 158 ? 42.70728 16.25546  -11.41201 1.000 48.93657  ? 490 PHE D CB  1 
ATOM   3493 C CG  . PHE D 2 158 ? 41.99753 17.22321  -10.51196 1.000 54.99511  ? 490 PHE D CG  1 
ATOM   3494 C CD1 . PHE D 2 158 ? 42.31378 18.57158  -10.53921 1.000 56.45030  ? 490 PHE D CD1 1 
ATOM   3495 C CD2 . PHE D 2 158 ? 41.00696 16.78939  -9.64646  1.000 53.76530  ? 490 PHE D CD2 1 
ATOM   3496 C CE1 . PHE D 2 158 ? 41.66075 19.46857  -9.71360  1.000 54.40377  ? 490 PHE D CE1 1 
ATOM   3497 C CE2 . PHE D 2 158 ? 40.34988 17.68302  -8.81806  1.000 51.55705  ? 490 PHE D CE2 1 
ATOM   3498 C CZ  . PHE D 2 158 ? 40.67761 19.02352  -8.85322  1.000 47.68827  ? 490 PHE D CZ  1 
ATOM   3499 N N   . PRO D 2 159 ? 44.28573 15.29023  -8.52988  1.000 50.49382  ? 491 PRO D N   1 
ATOM   3500 C CA  . PRO D 2 159 ? 44.38709 14.31562  -7.43177  1.000 44.97485  ? 491 PRO D CA  1 
ATOM   3501 C C   . PRO D 2 159 ? 43.05339 13.74552  -6.99130  1.000 44.78165  ? 491 PRO D C   1 
ATOM   3502 O O   . PRO D 2 159 ? 43.03171 12.65743  -6.40192  1.000 41.83522  ? 491 PRO D O   1 
ATOM   3503 C CB  . PRO D 2 159 ? 45.04173 15.12686  -6.30842  1.000 50.35479  ? 491 PRO D CB  1 
ATOM   3504 C CG  . PRO D 2 159 ? 44.58387 16.52694  -6.56587  1.000 49.43521  ? 491 PRO D CG  1 
ATOM   3505 C CD  . PRO D 2 159 ? 44.50685 16.67164  -8.06820  1.000 51.77368  ? 491 PRO D CD  1 
ATOM   3506 N N   . LEU D 2 160 ? 41.94833 14.43472  -7.25352  1.000 45.25128  ? 492 LEU D N   1 
ATOM   3507 C CA  . LEU D 2 160 ? 40.62960 13.98852  -6.83297  1.000 41.40212  ? 492 LEU D CA  1 
ATOM   3508 C C   . LEU D 2 160 ? 39.92205 13.26660  -7.97142  1.000 45.23029  ? 492 LEU D C   1 
ATOM   3509 O O   . LEU D 2 160 ? 39.98882 13.68830  -9.12977  1.000 50.36175  ? 492 LEU D O   1 
ATOM   3510 C CB  . LEU D 2 160 ? 39.77964 15.16914  -6.36243  1.000 42.98720  ? 492 LEU D CB  1 
ATOM   3511 C CG  . LEU D 2 160 ? 40.31285 15.94688  -5.15839  1.000 44.49007  ? 492 LEU D CG  1 
ATOM   3512 C CD1 . LEU D 2 160 ? 39.37681 17.09227  -4.81495  1.000 41.43832  ? 492 LEU D CD1 1 
ATOM   3513 C CD2 . LEU D 2 160 ? 40.50650 15.02788  -3.96394  1.000 40.08648  ? 492 LEU D CD2 1 
ATOM   3514 N N   . GLN D 2 161 ? 39.24867 12.17297  -7.63083  1.000 47.61579  ? 493 GLN D N   1 
ATOM   3515 C CA  . GLN D 2 161 ? 38.40916 11.43821  -8.56132  1.000 45.11348  ? 493 GLN D CA  1 
ATOM   3516 C C   . GLN D 2 161 ? 37.02494 11.28784  -7.95002  1.000 44.79839  ? 493 GLN D C   1 
ATOM   3517 O O   . GLN D 2 161 ? 36.87571 11.20277  -6.72813  1.000 48.58682  ? 493 GLN D O   1 
ATOM   3518 C CB  . GLN D 2 161 ? 39.00074 10.05924  -8.89190  1.000 44.08178  ? 493 GLN D CB  1 
ATOM   3519 C CG  . GLN D 2 161 ? 38.27357 9.31691   -10.00313 1.000 52.80465  ? 493 GLN D CG  1 
ATOM   3520 C CD  . GLN D 2 161 ? 38.32267 10.05495  -11.32978 1.000 54.32915  ? 493 GLN D CD  1 
ATOM   3521 O OE1 . GLN D 2 161 ? 39.29289 10.75006  -11.63260 1.000 50.70123  ? 493 GLN D OE1 1 
ATOM   3522 N NE2 . GLN D 2 161 ? 37.26954 9.91054   -12.12538 1.000 59.56632  ? 493 GLN D NE2 1 
ATOM   3523 N N   . SER D 2 162 ? 36.01249 11.26322  -8.80624  1.000 44.89550  ? 494 SER D N   1 
ATOM   3524 C CA  . SER D 2 162 ? 34.63533 11.19427  -8.34878  1.000 47.67236  ? 494 SER D CA  1 
ATOM   3525 C C   . SER D 2 162 ? 34.19533 9.75047   -8.13635  1.000 50.81354  ? 494 SER D C   1 
ATOM   3526 O O   . SER D 2 162 ? 34.64212 8.83130   -8.82871  1.000 47.89301  ? 494 SER D O   1 
ATOM   3527 C CB  . SER D 2 162 ? 33.70144 11.87544  -9.34864  1.000 46.58698  ? 494 SER D CB  1 
ATOM   3528 O OG  . SER D 2 162 ? 32.34930 11.69784  -8.96968  1.000 54.81819  ? 494 SER D OG  1 
ATOM   3529 N N   . TYR D 2 163 ? 33.32143 9.56065   -7.15122  1.000 51.78494  ? 495 TYR D N   1 
ATOM   3530 C CA  . TYR D 2 163 ? 32.60964 8.30252   -6.99882  1.000 48.12798  ? 495 TYR D CA  1 
ATOM   3531 C C   . TYR D 2 163 ? 31.48424 8.21699   -8.02099  1.000 49.92445  ? 495 TYR D C   1 
ATOM   3532 O O   . TYR D 2 163 ? 30.84417 9.21757   -8.35765  1.000 49.90583  ? 495 TYR D O   1 
ATOM   3533 C CB  . TYR D 2 163 ? 32.01910 8.16505   -5.59349  1.000 48.28531  ? 495 TYR D CB  1 
ATOM   3534 C CG  . TYR D 2 163 ? 32.98601 7.73913   -4.51096  1.000 43.04023  ? 495 TYR D CG  1 
ATOM   3535 C CD1 . TYR D 2 163 ? 33.54015 6.46540   -4.50525  1.000 43.76353  ? 495 TYR D CD1 1 
ATOM   3536 C CD2 . TYR D 2 163 ? 33.31415 8.60089   -3.47304  1.000 43.76624  ? 495 TYR D CD2 1 
ATOM   3537 C CE1 . TYR D 2 163 ? 34.41418 6.07068   -3.50614  1.000 43.60392  ? 495 TYR D CE1 1 
ATOM   3538 C CE2 . TYR D 2 163 ? 34.18313 8.21670   -2.46966  1.000 46.36141  ? 495 TYR D CE2 1 
ATOM   3539 C CZ  . TYR D 2 163 ? 34.73107 6.95223   -2.48881  1.000 45.82969  ? 495 TYR D CZ  1 
ATOM   3540 O OH  . TYR D 2 163 ? 35.59658 6.57370   -1.48637  1.000 36.70844  ? 495 TYR D OH  1 
ATOM   3541 N N   . GLY D 2 164 ? 31.24328 7.00552   -8.51079  1.000 50.68084  ? 496 GLY D N   1 
ATOM   3542 C CA  . GLY D 2 164 ? 30.14358 6.77218   -9.42349  1.000 46.08639  ? 496 GLY D CA  1 
ATOM   3543 C C   . GLY D 2 164 ? 29.07526 5.90094   -8.80088  1.000 44.67967  ? 496 GLY D C   1 
ATOM   3544 O O   . GLY D 2 164 ? 29.13500 4.67194   -8.89617  1.000 47.11622  ? 496 GLY D O   1 
ATOM   3545 N N   . PHE D 2 165 ? 28.09152 6.52316   -8.15756  1.000 44.27241  ? 497 PHE D N   1 
ATOM   3546 C CA  . PHE D 2 165 ? 27.06134 5.79774   -7.41617  1.000 47.91400  ? 497 PHE D CA  1 
ATOM   3547 C C   . PHE D 2 165 ? 25.83212 5.64423   -8.30563  1.000 48.84957  ? 497 PHE D C   1 
ATOM   3548 O O   . PHE D 2 165 ? 24.94542 6.49842   -8.33315  1.000 44.02172  ? 497 PHE D O   1 
ATOM   3549 C CB  . PHE D 2 165 ? 26.73798 6.51181   -6.11055  1.000 45.64233  ? 497 PHE D CB  1 
ATOM   3550 C CG  . PHE D 2 165 ? 27.85553 6.46793   -5.11328  1.000 47.90298  ? 497 PHE D CG  1 
ATOM   3551 C CD1 . PHE D 2 165 ? 28.61174 5.31744   -4.95703  1.000 47.00948  ? 497 PHE D CD1 1 
ATOM   3552 C CD2 . PHE D 2 165 ? 28.16429 7.57795   -4.34505  1.000 48.04504  ? 497 PHE D CD2 1 
ATOM   3553 C CE1 . PHE D 2 165 ? 29.64673 5.26886   -4.04177  1.000 49.19572  ? 497 PHE D CE1 1 
ATOM   3554 C CE2 . PHE D 2 165 ? 29.20048 7.53733   -3.43084  1.000 49.56772  ? 497 PHE D CE2 1 
ATOM   3555 C CZ  . PHE D 2 165 ? 29.94178 6.38074   -3.27820  1.000 45.09025  ? 497 PHE D CZ  1 
ATOM   3556 N N   . GLN D 2 166 ? 25.78877 4.54115   -9.03746  1.000 45.01050  ? 498 GLN D N   1 
ATOM   3557 C CA  . GLN D 2 166 ? 24.64934 4.12098   -9.83060  1.000 52.31299  ? 498 GLN D CA  1 
ATOM   3558 C C   . GLN D 2 166 ? 23.88480 3.02524   -9.10168  1.000 53.82280  ? 498 GLN D C   1 
ATOM   3559 O O   . GLN D 2 166 ? 24.48770 2.19208   -8.41823  1.000 52.98478  ? 498 GLN D O   1 
ATOM   3560 C CB  . GLN D 2 166 ? 25.09639 3.60421   -11.20277 1.000 54.97738  ? 498 GLN D CB  1 
ATOM   3561 C CG  . GLN D 2 166 ? 25.69236 4.67148   -12.09861 1.000 48.78780  ? 498 GLN D CG  1 
ATOM   3562 C CD  . GLN D 2 166 ? 26.28542 4.10778   -13.37178 1.000 49.24554  ? 498 GLN D CD  1 
ATOM   3563 O OE1 . GLN D 2 166 ? 26.47378 2.89879   -13.50045 1.000 56.66266  ? 498 GLN D OE1 1 
ATOM   3564 N NE2 . GLN D 2 166 ? 26.59021 4.98497   -14.32017 1.000 46.89919  ? 498 GLN D NE2 1 
ATOM   3565 N N   . PRO D 2 167 ? 22.55577 2.99743   -9.22938  1.000 57.25781  ? 499 PRO D N   1 
ATOM   3566 C CA  . PRO D 2 167 ? 21.76985 1.99997   -8.48234  1.000 60.08125  ? 499 PRO D CA  1 
ATOM   3567 C C   . PRO D 2 167 ? 22.07893 0.56396   -8.86838  1.000 61.26129  ? 499 PRO D C   1 
ATOM   3568 O O   . PRO D 2 167 ? 21.71873 -0.35309  -8.11993  1.000 60.39689  ? 499 PRO D O   1 
ATOM   3569 C CB  . PRO D 2 167 ? 20.32013 2.37253   -8.82059  1.000 57.85311  ? 499 PRO D CB  1 
ATOM   3570 C CG  . PRO D 2 167 ? 20.41479 3.08791   -10.13074 1.000 56.95317  ? 499 PRO D CG  1 
ATOM   3571 C CD  . PRO D 2 167 ? 21.70767 3.84689   -10.08221 1.000 49.32763  ? 499 PRO D CD  1 
ATOM   3572 N N   . THR D 2 168 ? 22.73590 0.33863   -10.00301 1.000 54.41567  ? 500 THR D N   1 
ATOM   3573 C CA  . THR D 2 168 ? 23.09142 -1.00005  -10.45110 1.000 60.80081  ? 500 THR D CA  1 
ATOM   3574 C C   . THR D 2 168 ? 24.43324 -1.47426  -9.90736  1.000 63.57088  ? 500 THR D C   1 
ATOM   3575 O O   . THR D 2 168 ? 24.82085 -2.61801  -10.17031 1.000 62.33197  ? 500 THR D O   1 
ATOM   3576 C CB  . THR D 2 168 ? 23.11518 -1.05085  -11.98137 1.000 56.41238  ? 500 THR D CB  1 
ATOM   3577 O OG1 . THR D 2 168 ? 24.06701 -0.10054  -12.47381 1.000 61.85876  ? 500 THR D OG1 1 
ATOM   3578 C CG2 . THR D 2 168 ? 21.74338 -0.71686  -12.54420 1.000 56.75481  ? 500 THR D CG2 1 
ATOM   3579 N N   . ASN D 2 169 ? 25.14570 -0.63118  -9.16260  1.000 58.28030  ? 501 ASN D N   1 
ATOM   3580 C CA  . ASN D 2 169 ? 26.44986 -1.01069  -8.63750  1.000 51.16669  ? 501 ASN D CA  1 
ATOM   3581 C C   . ASN D 2 169 ? 26.32218 -2.16160  -7.64813  1.000 55.74663  ? 501 ASN D C   1 
ATOM   3582 O O   . ASN D 2 169 ? 25.30323 -2.32001  -6.97010  1.000 60.42675  ? 501 ASN D O   1 
ATOM   3583 C CB  . ASN D 2 169 ? 27.11870 0.17924   -7.94734  1.000 48.86351  ? 501 ASN D CB  1 
ATOM   3584 C CG  . ASN D 2 169 ? 27.47012 1.29344   -8.90887  1.000 55.22567  ? 501 ASN D CG  1 
ATOM   3585 O OD1 . ASN D 2 169 ? 27.05091 1.28726   -10.06624 1.000 60.14150  ? 501 ASN D OD1 1 
ATOM   3586 N ND2 . ASN D 2 169 ? 28.24367 2.26312   -8.43119  1.000 48.04963  ? 501 ASN D ND2 1 
ATOM   3587 N N   . GLY D 2 170 ? 27.37598 -2.97017  -7.56792  1.000 51.73334  ? 502 GLY D N   1 
ATOM   3588 C CA  . GLY D 2 170 ? 27.44973 -3.97161  -6.52431  1.000 49.94500  ? 502 GLY D CA  1 
ATOM   3589 C C   . GLY D 2 170 ? 27.45769 -3.34569  -5.14340  1.000 47.98589  ? 502 GLY D C   1 
ATOM   3590 O O   . GLY D 2 170 ? 27.77241 -2.16843  -4.96479  1.000 51.79237  ? 502 GLY D O   1 
ATOM   3591 N N   . VAL D 2 171 ? 27.09824 -4.16101  -4.14859  1.000 50.06418  ? 503 VAL D N   1 
ATOM   3592 C CA  . VAL D 2 171 ? 26.95680 -3.65818  -2.78324  1.000 50.68309  ? 503 VAL D CA  1 
ATOM   3593 C C   . VAL D 2 171 ? 28.26279 -3.04005  -2.29752  1.000 47.38946  ? 503 VAL D C   1 
ATOM   3594 O O   . VAL D 2 171 ? 28.26609 -1.97159  -1.67347  1.000 48.86403  ? 503 VAL D O   1 
ATOM   3595 C CB  . VAL D 2 171 ? 26.47516 -4.78246  -1.84799  1.000 47.76748  ? 503 VAL D CB  1 
ATOM   3596 C CG1 . VAL D 2 171 ? 26.40879 -4.28772  -0.41409  1.000 47.77003  ? 503 VAL D CG1 1 
ATOM   3597 C CG2 . VAL D 2 171 ? 25.11815 -5.29376  -2.29754  1.000 51.00543  ? 503 VAL D CG2 1 
ATOM   3598 N N   . GLY D 2 172 ? 29.39081 -3.68937  -2.58721  1.000 43.41223  ? 504 GLY D N   1 
ATOM   3599 C CA  . GLY D 2 172 ? 30.68981 -3.13726  -2.24127  1.000 44.10750  ? 504 GLY D CA  1 
ATOM   3600 C C   . GLY D 2 172 ? 31.05293 -1.87027  -2.98692  1.000 44.22895  ? 504 GLY D C   1 
ATOM   3601 O O   . GLY D 2 172 ? 32.02566 -1.20608  -2.61302  1.000 43.79877  ? 504 GLY D O   1 
ATOM   3602 N N   . TYR D 2 173 ? 30.30111 -1.52498  -4.02836  1.000 46.52104  ? 505 TYR D N   1 
ATOM   3603 C CA  . TYR D 2 173 ? 30.51981 -0.30339  -4.78729  1.000 48.65371  ? 505 TYR D CA  1 
ATOM   3604 C C   . TYR D 2 173 ? 29.38644 0.69447   -4.59982  1.000 44.25703  ? 505 TYR D C   1 
ATOM   3605 O O   . TYR D 2 173 ? 29.37023 1.73706   -5.26212  1.000 49.90556  ? 505 TYR D O   1 
ATOM   3606 C CB  . TYR D 2 173 ? 30.71883 -0.64238  -6.26802  1.000 46.64024  ? 505 TYR D CB  1 
ATOM   3607 C CG  . TYR D 2 173 ? 31.94517 -1.49618  -6.49326  1.000 44.40902  ? 505 TYR D CG  1 
ATOM   3608 C CD1 . TYR D 2 173 ? 33.19054 -0.91475  -6.68853  1.000 41.04742  ? 505 TYR D CD1 1 
ATOM   3609 C CD2 . TYR D 2 173 ? 31.86466 -2.88297  -6.47494  1.000 45.62424  ? 505 TYR D CD2 1 
ATOM   3610 C CE1 . TYR D 2 173 ? 34.31859 -1.68786  -6.87688  1.000 41.60363  ? 505 TYR D CE1 1 
ATOM   3611 C CE2 . TYR D 2 173 ? 32.98889 -3.66574  -6.66330  1.000 43.31163  ? 505 TYR D CE2 1 
ATOM   3612 C CZ  . TYR D 2 173 ? 34.21438 -3.06152  -6.86246  1.000 42.87909  ? 505 TYR D CZ  1 
ATOM   3613 O OH  . TYR D 2 173 ? 35.34201 -3.82988  -7.04828  1.000 43.59332  ? 505 TYR D OH  1 
ATOM   3614 N N   . GLN D 2 174 ? 28.44320 0.39742   -3.71252  1.000 46.13844  ? 506 GLN D N   1 
ATOM   3615 C CA  . GLN D 2 174 ? 27.37810 1.31994   -3.36887  1.000 46.54403  ? 506 GLN D CA  1 
ATOM   3616 C C   . GLN D 2 174 ? 27.84669 2.28542   -2.28366  1.000 44.52703  ? 506 GLN D C   1 
ATOM   3617 O O   . GLN D 2 174 ? 28.84017 2.02935   -1.59836  1.000 42.49359  ? 506 GLN D O   1 
ATOM   3618 C CB  . GLN D 2 174 ? 26.15067 0.54324   -2.90497  1.000 47.29814  ? 506 GLN D CB  1 
ATOM   3619 C CG  . GLN D 2 174 ? 25.44716 -0.21380  -4.01724  1.000 50.84427  ? 506 GLN D CG  1 
ATOM   3620 C CD  . GLN D 2 174 ? 24.16746 -0.87018  -3.55385  1.000 53.53568  ? 506 GLN D CD  1 
ATOM   3621 O OE1 . GLN D 2 174 ? 23.93043 -1.01493  -2.35593  1.000 55.43469  ? 506 GLN D OE1 1 
ATOM   3622 N NE2 . GLN D 2 174 ? 23.32748 -1.26482  -4.50342  1.000 65.51402  ? 506 GLN D NE2 1 
ATOM   3623 N N   . PRO D 2 175 ? 27.16283 3.41804   -2.12227  1.000 40.55976  ? 507 PRO D N   1 
ATOM   3624 C CA  . PRO D 2 175 ? 27.58131 4.38487   -1.10180  1.000 44.30317  ? 507 PRO D CA  1 
ATOM   3625 C C   . PRO D 2 175 ? 27.19011 3.94522   0.30178   1.000 42.27505  ? 507 PRO D C   1 
ATOM   3626 O O   . PRO D 2 175 ? 26.11080 3.39363   0.53177   1.000 42.64389  ? 507 PRO D O   1 
ATOM   3627 C CB  . PRO D 2 175 ? 26.83862 5.66300   -1.50873  1.000 40.95479  ? 507 PRO D CB  1 
ATOM   3628 C CG  . PRO D 2 175 ? 25.61353 5.15894   -2.18088  1.000 45.42854  ? 507 PRO D CG  1 
ATOM   3629 C CD  . PRO D 2 175 ? 26.04597 3.93314   -2.93357  1.000 45.22027  ? 507 PRO D CD  1 
ATOM   3630 N N   . TYR D 2 176 ? 28.09112 4.19687   1.24620   1.000 37.63856  ? 508 TYR D N   1 
ATOM   3631 C CA  . TYR D 2 176 ? 27.84139 3.95694   2.66125   1.000 46.23599  ? 508 TYR D CA  1 
ATOM   3632 C C   . TYR D 2 176 ? 28.15193 5.22728   3.43318   1.000 39.59253  ? 508 TYR D C   1 
ATOM   3633 O O   . TYR D 2 176 ? 29.21793 5.82230   3.24852   1.000 38.96742  ? 508 TYR D O   1 
ATOM   3634 C CB  . TYR D 2 176 ? 28.69084 2.79818   3.19445   1.000 46.84458  ? 508 TYR D CB  1 
ATOM   3635 C CG  . TYR D 2 176 ? 28.11268 1.42665   2.93007   1.000 48.63555  ? 508 TYR D CG  1 
ATOM   3636 C CD1 . TYR D 2 176 ? 27.98816 0.93893   1.63414   1.000 47.27790  ? 508 TYR D CD1 1 
ATOM   3637 C CD2 . TYR D 2 176 ? 27.70602 0.61236   3.97893   1.000 47.28922  ? 508 TYR D CD2 1 
ATOM   3638 C CE1 . TYR D 2 176 ? 27.46608 -0.31873  1.39102   1.000 48.74090  ? 508 TYR D CE1 1 
ATOM   3639 C CE2 . TYR D 2 176 ? 27.18341 -0.64474  3.74637   1.000 47.74873  ? 508 TYR D CE2 1 
ATOM   3640 C CZ  . TYR D 2 176 ? 27.06596 -1.10559  2.45122   1.000 50.69627  ? 508 TYR D CZ  1 
ATOM   3641 O OH  . TYR D 2 176 ? 26.54604 -2.35632  2.21909   1.000 51.51470  ? 508 TYR D OH  1 
ATOM   3642 N N   . ARG D 2 177 ? 27.22700 5.63884   4.29414   1.000 48.52743  ? 509 ARG D N   1 
ATOM   3643 C CA  . ARG D 2 177 ? 27.43355 6.79789   5.15328   1.000 45.24272  ? 509 ARG D CA  1 
ATOM   3644 C C   . ARG D 2 177 ? 28.15263 6.35548   6.42244   1.000 44.79335  ? 509 ARG D C   1 
ATOM   3645 O O   . ARG D 2 177 ? 27.68029 5.46141   7.13163   1.000 47.43718  ? 509 ARG D O   1 
ATOM   3646 C CB  . ARG D 2 177 ? 26.10265 7.47593   5.47528   1.000 45.13558  ? 509 ARG D CB  1 
ATOM   3647 C CG  . ARG D 2 177 ? 25.50213 8.18780   4.27634   1.000 45.31340  ? 509 ARG D CG  1 
ATOM   3648 C CD  . ARG D 2 177 ? 24.21439 8.92113   4.59805   1.000 42.76214  ? 509 ARG D CD  1 
ATOM   3649 N NE  . ARG D 2 177 ? 23.89568 9.88105   3.54779   1.000 46.42912  ? 509 ARG D NE  1 
ATOM   3650 C CZ  . ARG D 2 177 ? 22.84170 10.68498  3.55269   1.000 48.02153  ? 509 ARG D CZ  1 
ATOM   3651 N NH1 . ARG D 2 177 ? 21.95632 10.65846  4.53368   1.000 55.54299  ? 509 ARG D NH1 1 
ATOM   3652 N NH2 . ARG D 2 177 ? 22.67338 11.53897  2.54745   1.000 51.69008  ? 509 ARG D NH2 1 
ATOM   3653 N N   . VAL D 2 178 ? 29.29718 6.97467   6.69746   1.000 46.28203  ? 510 VAL D N   1 
ATOM   3654 C CA  . VAL D 2 178 ? 30.15535 6.61105   7.81820   1.000 38.29221  ? 510 VAL D CA  1 
ATOM   3655 C C   . VAL D 2 178 ? 30.14184 7.74217   8.83580   1.000 42.69840  ? 510 VAL D C   1 
ATOM   3656 O O   . VAL D 2 178 ? 30.22439 8.91977   8.46962   1.000 44.18201  ? 510 VAL D O   1 
ATOM   3657 C CB  . VAL D 2 178 ? 31.59370 6.31391   7.34813   1.000 35.02709  ? 510 VAL D CB  1 
ATOM   3658 C CG1 . VAL D 2 178 ? 32.48524 5.95618   8.52806   1.000 40.49494  ? 510 VAL D CG1 1 
ATOM   3659 C CG2 . VAL D 2 178 ? 31.59505 5.19802   6.31921   1.000 33.69205  ? 510 VAL D CG2 1 
ATOM   3660 N N   . VAL D 2 179 ? 30.02948 7.38248   10.11370  1.000 45.07830  ? 511 VAL D N   1 
ATOM   3661 C CA  . VAL D 2 179 ? 30.12130 8.32739   11.22215  1.000 41.72764  ? 511 VAL D CA  1 
ATOM   3662 C C   . VAL D 2 179 ? 31.15987 7.79718   12.19945  1.000 40.23168  ? 511 VAL D C   1 
ATOM   3663 O O   . VAL D 2 179 ? 31.04149 6.66337   12.67897  1.000 39.34162  ? 511 VAL D O   1 
ATOM   3664 C CB  . VAL D 2 179 ? 28.77217 8.53281   11.92964  1.000 42.11217  ? 511 VAL D CB  1 
ATOM   3665 C CG1 . VAL D 2 179 ? 28.95085 9.41543   13.15695  1.000 44.33191  ? 511 VAL D CG1 1 
ATOM   3666 C CG2 . VAL D 2 179 ? 27.76082 9.14110   10.97676  1.000 40.87293  ? 511 VAL D CG2 1 
ATOM   3667 N N   . VAL D 2 180 ? 32.17326 8.60778   12.48986  1.000 38.41369  ? 512 VAL D N   1 
ATOM   3668 C CA  . VAL D 2 180 ? 33.25791 8.23250   13.38919  1.000 35.12381  ? 512 VAL D CA  1 
ATOM   3669 C C   . VAL D 2 180 ? 33.15163 9.10504   14.63248  1.000 43.00651  ? 512 VAL D C   1 
ATOM   3670 O O   . VAL D 2 180 ? 33.32738 10.32842  14.56324  1.000 39.90785  ? 512 VAL D O   1 
ATOM   3671 C CB  . VAL D 2 180 ? 34.63236 8.38111   12.72520  1.000 38.73882  ? 512 VAL D CB  1 
ATOM   3672 C CG1 . VAL D 2 180 ? 35.72482 7.90979   13.66851  1.000 43.07484  ? 512 VAL D CG1 1 
ATOM   3673 C CG2 . VAL D 2 180 ? 34.67929 7.60284   11.41921  1.000 45.19561  ? 512 VAL D CG2 1 
ATOM   3674 N N   . LEU D 2 181 ? 32.87308 8.47757   15.77208  1.000 40.22219  ? 513 LEU D N   1 
ATOM   3675 C CA  . LEU D 2 181 ? 32.72666 9.17524   17.04315  1.000 39.61070  ? 513 LEU D CA  1 
ATOM   3676 C C   . LEU D 2 181 ? 34.02778 9.07178   17.82955  1.000 38.46973  ? 513 LEU D C   1 
ATOM   3677 O O   . LEU D 2 181 ? 34.45056 7.96950   18.19342  1.000 40.60021  ? 513 LEU D O   1 
ATOM   3678 C CB  . LEU D 2 181 ? 31.56586 8.59457   17.84948  1.000 35.24158  ? 513 LEU D CB  1 
ATOM   3679 C CG  . LEU D 2 181 ? 30.18243 8.69415   17.20583  1.000 38.18411  ? 513 LEU D CG  1 
ATOM   3680 C CD1 . LEU D 2 181 ? 29.14279 7.97919   18.05494  1.000 37.65320  ? 513 LEU D CD1 1 
ATOM   3681 C CD2 . LEU D 2 181 ? 29.79611 10.14631  16.98333  1.000 33.40894  ? 513 LEU D CD2 1 
ATOM   3682 N N   . SER D 2 182 ? 34.65795 10.21479  18.08480  1.000 36.73263  ? 514 SER D N   1 
ATOM   3683 C CA  . SER D 2 182 ? 35.85848 10.28645  18.90696  1.000 41.45912  ? 514 SER D CA  1 
ATOM   3684 C C   . SER D 2 182 ? 35.48701 10.78267  20.29809  1.000 36.84239  ? 514 SER D C   1 
ATOM   3685 O O   . SER D 2 182 ? 34.73718 11.75396  20.43698  1.000 39.56916  ? 514 SER D O   1 
ATOM   3686 C CB  . SER D 2 182 ? 36.90292 11.20914  18.27806  1.000 37.82409  ? 514 SER D CB  1 
ATOM   3687 O OG  . SER D 2 182 ? 37.36228 10.68690  17.04555  1.000 52.82138  ? 514 SER D OG  1 
ATOM   3688 N N   . PHE D 2 183 ? 36.00892 10.11706  21.32023  1.000 39.62812  ? 515 PHE D N   1 
ATOM   3689 C CA  . PHE D 2 183 ? 35.68431 10.42612  22.70907  1.000 38.86464  ? 515 PHE D CA  1 
ATOM   3690 C C   . PHE D 2 183 ? 36.88280 11.11804  23.34604  1.000 40.49447  ? 515 PHE D C   1 
ATOM   3691 O O   . PHE D 2 183 ? 37.89422 10.47397  23.64593  1.000 33.38772  ? 515 PHE D O   1 
ATOM   3692 C CB  . PHE D 2 183 ? 35.29785 9.15994   23.46493  1.000 37.50230  ? 515 PHE D CB  1 
ATOM   3693 C CG  . PHE D 2 183 ? 34.09987 8.46304   22.89432  1.000 41.24711  ? 515 PHE D CG  1 
ATOM   3694 C CD1 . PHE D 2 183 ? 32.86938 9.09434   22.85976  1.000 39.92268  ? 515 PHE D CD1 1 
ATOM   3695 C CD2 . PHE D 2 183 ? 34.20221 7.17741   22.39317  1.000 48.13804  ? 515 PHE D CD2 1 
ATOM   3696 C CE1 . PHE D 2 183 ? 31.76314 8.45809   22.33240  1.000 47.11317  ? 515 PHE D CE1 1 
ATOM   3697 C CE2 . PHE D 2 183 ? 33.09842 6.53554   21.86534  1.000 50.93969  ? 515 PHE D CE2 1 
ATOM   3698 C CZ  . PHE D 2 183 ? 31.87803 7.17748   21.83420  1.000 49.05658  ? 515 PHE D CZ  1 
ATOM   3699 N N   . GLU D 2 184 ? 36.76168 12.42679  23.55406  1.000 39.06100  ? 516 GLU D N   1 
ATOM   3700 C CA  . GLU D 2 184 ? 37.87318 13.24154  24.02773  1.000 43.36953  ? 516 GLU D CA  1 
ATOM   3701 C C   . GLU D 2 184 ? 37.99949 13.12627  25.54354  1.000 45.89895  ? 516 GLU D C   1 
ATOM   3702 O O   . GLU D 2 184 ? 37.04205 13.40141  26.27472  1.000 50.52059  ? 516 GLU D O   1 
ATOM   3703 C CB  . GLU D 2 184 ? 37.66484 14.69568  23.61193  1.000 45.77263  ? 516 GLU D CB  1 
ATOM   3704 C CG  . GLU D 2 184 ? 38.90158 15.56405  23.72347  1.000 46.27893  ? 516 GLU D CG  1 
ATOM   3705 C CD  . GLU D 2 184 ? 38.63540 17.00006  23.32589  1.000 48.68594  ? 516 GLU D CD  1 
ATOM   3706 O OE1 . GLU D 2 184 ? 37.52242 17.49330  23.60019  1.000 47.67958  ? 516 GLU D OE1 1 
ATOM   3707 O OE2 . GLU D 2 184 ? 39.53430 17.63409  22.73399  1.000 51.65863  ? 516 GLU D OE2 1 
ATOM   3708 N N   . LEU D 2 185 ? 39.18095 12.72513  26.01394  1.000 50.69305  ? 517 LEU D N   1 
ATOM   3709 C CA  . LEU D 2 185 ? 39.44899 12.64177  27.44571  1.000 51.93273  ? 517 LEU D CA  1 
ATOM   3710 C C   . LEU D 2 185 ? 40.47798 13.68442  27.86798  1.000 48.91687  ? 517 LEU D C   1 
ATOM   3711 O O   . LEU D 2 185 ? 41.59316 13.34148  28.27372  1.000 49.30298  ? 517 LEU D O   1 
ATOM   3712 C CB  . LEU D 2 185 ? 39.92484 11.23675  27.82483  1.000 53.67243  ? 517 LEU D CB  1 
ATOM   3713 C CG  . LEU D 2 185 ? 38.84233 10.16243  27.94510  1.000 54.12048  ? 517 LEU D CG  1 
ATOM   3714 C CD1 . LEU D 2 185 ? 39.46701 8.78796   28.13337  1.000 50.34368  ? 517 LEU D CD1 1 
ATOM   3715 C CD2 . LEU D 2 185 ? 37.90764 10.49287  29.09944  1.000 54.12759  ? 517 LEU D CD2 1 
ATOM   3716 N N   . LEU D 2 186 ? 40.11367 14.95847  27.76674  1.000 47.94689  ? 518 LEU D N   1 
ATOM   3717 C CA  . LEU D 2 186 ? 40.97309 16.03663  28.22416  1.000 52.10786  ? 518 LEU D CA  1 
ATOM   3718 C C   . LEU D 2 186 ? 40.93804 16.13862  29.74739  1.000 54.60596  ? 518 LEU D C   1 
ATOM   3719 O O   . LEU D 2 186 ? 40.01199 15.66093  30.40891  1.000 53.42758  ? 518 LEU D O   1 
ATOM   3720 C CB  . LEU D 2 186 ? 40.54126 17.36478  27.60263  1.000 50.53514  ? 518 LEU D CB  1 
ATOM   3721 C CG  . LEU D 2 186 ? 41.40070 17.95091  26.48341  1.000 54.56842  ? 518 LEU D CG  1 
ATOM   3722 C CD1 . LEU D 2 186 ? 41.76044 16.89169  25.45591  1.000 54.71818  ? 518 LEU D CD1 1 
ATOM   3723 C CD2 . LEU D 2 186 ? 40.67063 19.11285  25.82415  1.000 54.56588  ? 518 LEU D CD2 1 
ATOM   3724 N N   . HIS D 2 187 ? 41.97101 16.77438  30.30382  1.000 52.74071  ? 519 HIS D N   1 
ATOM   3725 C CA  . HIS D 2 187 ? 42.03815 17.03739  31.74304  1.000 52.33504  ? 519 HIS D CA  1 
ATOM   3726 C C   . HIS D 2 187 ? 41.14776 18.23877  32.06029  1.000 50.11820  ? 519 HIS D C   1 
ATOM   3727 O O   . HIS D 2 187 ? 41.60351 19.33807  32.38133  1.000 48.08348  ? 519 HIS D O   1 
ATOM   3728 C CB  . HIS D 2 187 ? 43.47668 17.26807  32.18148  1.000 45.36198  ? 519 HIS D CB  1 
ATOM   3729 C CG  . HIS D 2 187 ? 44.36788 16.08444  31.97235  1.000 49.42018  ? 519 HIS D CG  1 
ATOM   3730 N ND1 . HIS D 2 187 ? 45.69991 16.08546  32.32336  1.000 53.38058  ? 519 HIS D ND1 1 
ATOM   3731 C CD2 . HIS D 2 187 ? 44.11798 14.86028  31.45016  1.000 59.55860  ? 519 HIS D CD2 1 
ATOM   3732 C CE1 . HIS D 2 187 ? 46.23297 14.91343  32.02789  1.000 56.38458  ? 519 HIS D CE1 1 
ATOM   3733 N NE2 . HIS D 2 187 ? 45.29450 14.15232  31.49489  1.000 63.63058  ? 519 HIS D NE2 1 
ATOM   3734 N N   . ALA D 2 188 ? 39.84410 18.00339  31.96539  1.000 51.40320  ? 520 ALA D N   1 
ATOM   3735 C CA  . ALA D 2 188 ? 38.85324 19.06595  32.03426  1.000 48.73285  ? 520 ALA D CA  1 
ATOM   3736 C C   . ALA D 2 188 ? 37.53503 18.45589  32.48812  1.000 49.14790  ? 520 ALA D C   1 
ATOM   3737 O O   . ALA D 2 188 ? 37.38415 17.22503  32.49676  1.000 50.90478  ? 520 ALA D O   1 
ATOM   3738 C CB  . ALA D 2 188 ? 38.70085 19.77033  30.67316  1.000 52.23081  ? 520 ALA D CB  1 
ATOM   3739 N N   . PRO D 2 189 ? 36.56795 19.27848  32.89485  1.000 51.93995  ? 521 PRO D N   1 
ATOM   3740 C CA  . PRO D 2 189 ? 35.25088 18.73516  33.24910  1.000 50.91792  ? 521 PRO D CA  1 
ATOM   3741 C C   . PRO D 2 189 ? 34.58358 18.09264  32.04195  1.000 50.97379  ? 521 PRO D C   1 
ATOM   3742 O O   . PRO D 2 189 ? 34.52319 18.67724  30.95779  1.000 53.42773  ? 521 PRO D O   1 
ATOM   3743 C CB  . PRO D 2 189 ? 34.47499 19.96576  33.73556  1.000 48.23329  ? 521 PRO D CB  1 
ATOM   3744 C CG  . PRO D 2 189 ? 35.51375 20.95396  34.11467  1.000 49.31756  ? 521 PRO D CG  1 
ATOM   3745 C CD  . PRO D 2 189 ? 36.65313 20.72378  33.17676  1.000 49.99613  ? 521 PRO D CD  1 
ATOM   3746 N N   . ALA D 2 190 ? 34.08177 16.87819  32.23797  1.000 50.66716  ? 522 ALA D N   1 
ATOM   3747 C CA  . ALA D 2 190 ? 33.37254 16.18643  31.17234  1.000 48.35353  ? 522 ALA D CA  1 
ATOM   3748 C C   . ALA D 2 190 ? 32.07003 16.90983  30.85342  1.000 46.49164  ? 522 ALA D C   1 
ATOM   3749 O O   . ALA D 2 190 ? 31.29188 17.23724  31.75428  1.000 49.76651  ? 522 ALA D O   1 
ATOM   3750 C CB  . ALA D 2 190 ? 33.09550 14.73973  31.57395  1.000 45.81371  ? 522 ALA D CB  1 
ATOM   3751 N N   . THR D 2 191 ? 31.83798 17.17000  29.56636  1.000 48.23985  ? 523 THR D N   1 
ATOM   3752 C CA  . THR D 2 191 ? 30.60906 17.80558  29.11704  1.000 45.31316  ? 523 THR D CA  1 
ATOM   3753 C C   . THR D 2 191 ? 29.64947 16.84208  28.43475  1.000 48.18820  ? 523 THR D C   1 
ATOM   3754 O O   . THR D 2 191 ? 28.50876 17.22759  28.15221  1.000 46.33857  ? 523 THR D O   1 
ATOM   3755 C CB  . THR D 2 191 ? 30.92133 18.96473  28.15713  1.000 53.35351  ? 523 THR D CB  1 
ATOM   3756 O OG1 . THR D 2 191 ? 31.49261 18.45202  26.94709  1.000 48.35289  ? 523 THR D OG1 1 
ATOM   3757 C CG2 . THR D 2 191 ? 31.89859 19.94196  28.79826  1.000 52.26180  ? 523 THR D CG2 1 
ATOM   3758 N N   . VAL D 2 192 ? 30.07451 15.61068  28.15853  1.000 41.86725  ? 524 VAL D N   1 
ATOM   3759 C CA  . VAL D 2 192 ? 29.23018 14.60876  27.51667  1.000 50.28806  ? 524 VAL D CA  1 
ATOM   3760 C C   . VAL D 2 192 ? 29.23652 13.36301  28.38928  1.000 46.22352  ? 524 VAL D C   1 
ATOM   3761 O O   . VAL D 2 192 ? 30.29002 12.74664  28.58547  1.000 44.98507  ? 524 VAL D O   1 
ATOM   3762 C CB  . VAL D 2 192 ? 29.70344 14.26933  26.09211  1.000 44.96352  ? 524 VAL D CB  1 
ATOM   3763 C CG1 . VAL D 2 192 ? 28.61035 13.52900  25.33633  1.000 47.74381  ? 524 VAL D CG1 1 
ATOM   3764 C CG2 . VAL D 2 192 ? 30.12240 15.52563  25.35146  1.000 40.25528  ? 524 VAL D CG2 1 
ATOM   3765 N N   . CYS D 2 193 ? 28.06673 12.99031  28.90482  1.000 46.11411  ? 525 CYS D N   1 
ATOM   3766 C CA  . CYS D 2 193 ? 27.92593 11.82947  29.77009  1.000 50.66787  ? 525 CYS D CA  1 
ATOM   3767 C C   . CYS D 2 193 ? 26.84283 10.90821  29.23368  1.000 47.20456  ? 525 CYS D C   1 
ATOM   3768 O O   . CYS D 2 193 ? 25.86908 11.35640  28.62267  1.000 49.62660  ? 525 CYS D O   1 
ATOM   3769 C CB  . CYS D 2 193 ? 27.57579 12.22722  31.21395  1.000 55.65219  ? 525 CYS D CB  1 
ATOM   3770 S SG  . CYS D 2 193 ? 28.93661 12.90681  32.18206  1.000 49.32334  ? 525 CYS D SG  1 
ATOM   3771 N N   . GLY D 2 194 ? 27.01194 9.61638   29.49127  1.000 48.45205  ? 526 GLY D N   1 
ATOM   3772 C CA  . GLY D 2 194 ? 26.02713 8.63370   29.10369  1.000 56.78743  ? 526 GLY D CA  1 
ATOM   3773 C C   . GLY D 2 194 ? 24.72614 8.79676   29.87196  1.000 54.76848  ? 526 GLY D C   1 
ATOM   3774 O O   . GLY D 2 194 ? 24.51571 9.74163   30.63318  1.000 61.68134  ? 526 GLY D O   1 
ATOM   3775 N N   . SER D 2 195 ? 23.83072 7.83210   29.65681  1.000 56.71200  ? 527 SER D N   1 
ATOM   3776 C CA  . SER D 2 195 ? 22.53053 7.87004   30.31665  1.000 63.73124  ? 527 SER D CA  1 
ATOM   3777 C C   . SER D 2 195 ? 22.62412 7.44781   31.77786  1.000 64.81409  ? 527 SER D C   1 
ATOM   3778 O O   . SER D 2 195 ? 22.02559 8.08722   32.64946  1.000 70.99402  ? 527 SER D O   1 
ATOM   3779 C CB  . SER D 2 195 ? 21.53790 6.97698   29.57352  1.000 61.32440  ? 527 SER D CB  1 
ATOM   3780 O OG  . SER D 2 195 ? 21.29655 7.46563   28.26978  1.000 66.12602  ? 527 SER D OG  1 
ATOM   3781 N N   . ASN D 2 196 ? 23.36397 6.38265   32.06250  1.000 64.58960  ? 528 ASN D N   1 
ATOM   3782 C CA  . ASN D 2 196 ? 23.44901 5.80081   33.39960  1.000 70.07231  ? 528 ASN D CA  1 
ATOM   3783 C C   . ASN D 2 196 ? 24.89038 5.90594   33.89231  1.000 68.98264  ? 528 ASN D C   1 
ATOM   3784 O O   . ASN D 2 196 ? 25.56385 4.89171   34.09848  1.000 68.30387  ? 528 ASN D O   1 
ATOM   3785 C CB  . ASN D 2 196 ? 22.96147 4.34598   33.37987  1.000 71.81382  ? 528 ASN D CB  1 
ATOM   3786 C CG  . ASN D 2 196 ? 21.57160 4.20611   32.78839  1.000 72.92535  ? 528 ASN D CG  1 
ATOM   3787 O OD1 . ASN D 2 196 ? 20.57554 4.19530   33.51222  1.000 82.15683  ? 528 ASN D OD1 1 
ATOM   3788 N ND2 . ASN D 2 196 ? 21.49729 4.10213   31.46549  1.000 61.78978  ? 528 ASN D ND2 1 
ATOM   3789 N N   . SER D 2 197 ? 25.35834 7.13790   34.09126  1.000 69.93085  ? 529 SER D N   1 
ATOM   3790 C CA  . SER D 2 197 ? 26.74488 7.40138   34.45844  1.000 73.61828  ? 529 SER D CA  1 
ATOM   3791 C C   . SER D 2 197 ? 26.91366 7.84547   35.90428  1.000 73.05768  ? 529 SER D C   1 
ATOM   3792 O O   . SER D 2 197 ? 27.72195 7.26413   36.63512  1.000 78.01329  ? 529 SER D O   1 
ATOM   3793 C CB  . SER D 2 197 ? 27.34332 8.45673   33.51518  1.000 63.71409  ? 529 SER D CB  1 
ATOM   3794 O OG  . SER D 2 197 ? 26.53119 9.61596   33.46128  1.000 69.03749  ? 529 SER D OG  1 
ATOM   3795 N N   . GLU D 2 198 ? 26.18024 8.86612   36.34053  1.000 71.92248  ? 530 GLU D N   1 
ATOM   3796 C CA  . GLU D 2 198 ? 26.31646 9.37245   37.70574  1.000 77.74430  ? 530 GLU D CA  1 
ATOM   3797 C C   . GLU D 2 198 ? 25.82737 8.35843   38.73496  1.000 68.11140  ? 530 GLU D C   1 
ATOM   3798 O O   . GLU D 2 198 ? 25.12948 7.40293   38.39773  1.000 72.53402  ? 530 GLU D O   1 
ATOM   3799 C CB  . GLU D 2 198 ? 25.55466 10.68945  37.87225  1.000 77.48818  ? 530 GLU D CB  1 
ATOM   3800 C CG  . GLU D 2 198 ? 26.17836 11.86517  37.13926  1.000 84.12244  ? 530 GLU D CG  1 
ATOM   3801 C CD  . GLU D 2 198 ? 25.27987 12.42032  36.05136  1.000 85.72699  ? 530 GLU D CD  1 
ATOM   3802 O OE1 . GLU D 2 198 ? 24.13607 11.93532  35.91514  1.000 85.47312  ? 530 GLU D OE1 1 
ATOM   3803 O OE2 . GLU D 2 198 ? 25.71908 13.34261  35.33214  1.000 83.51502  ? 530 GLU D OE2 1 
HETATM 3804 C C1  . NAG E 3 .   ? 40.36962 -44.15833 -13.82085 1.000 86.05505  ? 601 NAG B C1  1 
HETATM 3805 C C2  . NAG E 3 .   ? 39.74533 -44.20558 -15.21203 1.000 86.33143  ? 601 NAG B C2  1 
HETATM 3806 C C3  . NAG E 3 .   ? 39.05728 -45.54960 -15.42748 1.000 91.45583  ? 601 NAG B C3  1 
HETATM 3807 C C4  . NAG E 3 .   ? 40.03492 -46.69059 -15.17451 1.000 92.72984  ? 601 NAG B C4  1 
HETATM 3808 C C5  . NAG E 3 .   ? 40.69413 -46.54310 -13.80306 1.000 90.54631  ? 601 NAG B C5  1 
HETATM 3809 C C6  . NAG E 3 .   ? 41.78818 -47.55797 -13.56412 1.000 93.71732  ? 601 NAG B C6  1 
HETATM 3810 C C7  . NAG E 3 .   ? 39.09696 -42.03139 -16.14162 1.000 70.96659  ? 601 NAG B C7  1 
HETATM 3811 C C8  . NAG E 3 .   ? 38.01771 -40.99723 -16.23991 1.000 62.98147  ? 601 NAG B C8  1 
HETATM 3812 N N2  . NAG E 3 .   ? 38.80904 -43.11138 -15.40826 1.000 78.17750  ? 601 NAG B N2  1 
HETATM 3813 O O3  . NAG E 3 .   ? 38.55081 -45.62199 -16.75574 1.000 94.37617  ? 601 NAG B O3  1 
HETATM 3814 O O4  . NAG E 3 .   ? 39.35030 -47.93726 -15.22897 1.000 88.37832  ? 601 NAG B O4  1 
HETATM 3815 O O5  . NAG E 3 .   ? 41.29836 -45.24569 -13.67341 1.000 88.74210  ? 601 NAG B O5  1 
HETATM 3816 O O6  . NAG E 3 .   ? 42.00252 -48.37073 -14.71008 1.000 90.58389  ? 601 NAG B O6  1 
HETATM 3817 O O7  . NAG E 3 .   ? 40.18094 -41.89575 -16.70000 1.000 74.87719  ? 601 NAG B O7  1 
HETATM 3818 C C1  . GOL F 4 .   ? 45.01678 -39.25614 -14.78526 1.000 71.87046  ? 602 GOL B C1  1 
HETATM 3819 O O1  . GOL F 4 .   ? 44.64858 -40.53408 -15.20355 1.000 76.74028  ? 602 GOL B O1  1 
HETATM 3820 C C2  . GOL F 4 .   ? 45.68643 -39.41175 -13.39866 1.000 79.33173  ? 602 GOL B C2  1 
HETATM 3821 O O2  . GOL F 4 .   ? 47.06909 -39.49998 -13.49241 1.000 79.79072  ? 602 GOL B O2  1 
HETATM 3822 C C3  . GOL F 4 .   ? 45.22730 -38.17646 -12.59091 1.000 71.80782  ? 602 GOL B C3  1 
HETATM 3823 O O3  . GOL F 4 .   ? 45.66430 -38.37159 -11.28205 1.000 68.71958  ? 602 GOL B O3  1 
HETATM 3824 C C1  . GOL G 4 .   ? 19.91084 -8.81025  7.56618   1.000 59.78024  ? 603 GOL B C1  1 
HETATM 3825 O O1  . GOL G 4 .   ? 18.80454 -8.57693  8.37943   1.000 61.47921  ? 603 GOL B O1  1 
HETATM 3826 C C2  . GOL G 4 .   ? 20.41985 -7.42618  7.09970   1.000 61.15366  ? 603 GOL B C2  1 
HETATM 3827 O O2  . GOL G 4 .   ? 21.14249 -6.77798  8.09178   1.000 66.45255  ? 603 GOL B O2  1 
HETATM 3828 C C3  . GOL G 4 .   ? 21.27004 -7.70816  5.83093   1.000 64.95673  ? 603 GOL B C3  1 
HETATM 3829 O O3  . GOL G 4 .   ? 20.38975 -8.11965  4.82863   1.000 53.72841  ? 603 GOL B O3  1 
HETATM 3830 C C1  . GOL H 4 .   ? 23.98622 -9.92930  22.65641  1.000 63.09308  ? 604 GOL B C1  1 
HETATM 3831 O O1  . GOL H 4 .   ? 22.78903 -9.37356  22.21237  1.000 67.61098  ? 604 GOL B O1  1 
HETATM 3832 C C2  . GOL H 4 .   ? 23.67347 -10.64035 23.99089  1.000 70.73122  ? 604 GOL B C2  1 
HETATM 3833 O O2  . GOL H 4 .   ? 24.78560 -10.70700 24.81452  1.000 70.93430  ? 604 GOL B O2  1 
HETATM 3834 C C3  . GOL H 4 .   ? 23.16506 -12.04326 23.58417  1.000 69.07270  ? 604 GOL B C3  1 
HETATM 3835 O O3  . GOL H 4 .   ? 22.86421 -12.71951 24.76912  1.000 67.96676  ? 604 GOL B O3  1 
HETATM 3836 C C1  . GOL I 4 .   ? 39.18498 -3.94375  -2.56687  1.000 66.79578  ? 101 GOL C C1  1 
HETATM 3837 O O1  . GOL I 4 .   ? 39.26769 -4.57658  -1.32918  1.000 68.76403  ? 101 GOL C O1  1 
HETATM 3838 C C2  . GOL I 4 .   ? 40.58422 -3.35646  -2.85839  1.000 67.78070  ? 101 GOL C C2  1 
HETATM 3839 O O2  . GOL I 4 .   ? 40.63623 -2.73008  -4.09415  1.000 65.78931  ? 101 GOL C O2  1 
HETATM 3840 C C3  . GOL I 4 .   ? 40.85380 -2.37811  -1.69464  1.000 66.51876  ? 101 GOL C C3  1 
HETATM 3841 O O3  . GOL I 4 .   ? 42.21455 -2.08062  -1.73043  1.000 74.11287  ? 101 GOL C O3  1 
HETATM 3842 C C1  . GOL J 4 .   ? 28.34460 10.03623  -16.99037 1.000 61.53190  ? 601 GOL D C1  1 
HETATM 3843 O O1  . GOL J 4 .   ? 28.06815 9.65254   -18.30116 1.000 55.74355  ? 601 GOL D O1  1 
HETATM 3844 C C2  . GOL J 4 .   ? 28.73281 11.53351  -17.03384 1.000 62.89962  ? 601 GOL D C2  1 
HETATM 3845 O O2  . GOL J 4 .   ? 29.74745 11.78063  -17.94872 1.000 64.44295  ? 601 GOL D O2  1 
HETATM 3846 C C3  . GOL J 4 .   ? 29.15645 11.87693  -15.58480 1.000 63.85662  ? 601 GOL D C3  1 
HETATM 3847 O O3  . GOL J 4 .   ? 30.28246 11.10332  -15.29746 1.000 58.28156  ? 601 GOL D O3  1 
HETATM 3848 C C1  . NAG K 3 .   ? 16.68757 9.58911   12.83151  1.000 72.30987  ? 602 NAG D C1  1 
HETATM 3849 C C2  . NAG K 3 .   ? 17.03410 9.40587   14.31244  1.000 76.61219  ? 602 NAG D C2  1 
HETATM 3850 C C3  . NAG K 3 .   ? 16.31192 8.18676   14.88072  1.000 75.75275  ? 602 NAG D C3  1 
HETATM 3851 C C4  . NAG K 3 .   ? 14.81452 8.29060   14.62706  1.000 81.71784  ? 602 NAG D C4  1 
HETATM 3852 C C5  . NAG K 3 .   ? 14.55138 8.49342   13.13789  1.000 80.94578  ? 602 NAG D C5  1 
HETATM 3853 C C6  . NAG K 3 .   ? 13.09060 8.71707   12.82231  1.000 84.73909  ? 602 NAG D C6  1 
HETATM 3854 C C7  . NAG K 3 .   ? 19.13501 9.90312   15.47975  1.000 64.73144  ? 602 NAG D C7  1 
HETATM 3855 C C8  . NAG K 3 .   ? 20.61326 9.66044   15.52710  1.000 55.35909  ? 602 NAG D C8  1 
HETATM 3856 N N2  . NAG K 3 .   ? 18.47031 9.28078   14.50108  1.000 72.70407  ? 602 NAG D N2  1 
HETATM 3857 O O3  . NAG K 3 .   ? 16.56252 8.09217   16.27815  1.000 75.72471  ? 602 NAG D O3  1 
HETATM 3858 O O4  . NAG K 3 .   ? 14.16118 7.10627   15.07000  1.000 80.92907  ? 602 NAG D O4  1 
HETATM 3859 O O5  . NAG K 3 .   ? 15.25642 9.65422   12.67227  1.000 79.66646  ? 602 NAG D O5  1 
HETATM 3860 O O6  . NAG K 3 .   ? 12.46842 9.54272   13.79759  1.000 90.59859  ? 602 NAG D O6  1 
HETATM 3861 O O7  . NAG K 3 .   ? 18.56904 10.63114  16.28856  1.000 67.01146  ? 602 NAG D O7  1 
HETATM 3862 O O   . HOH L 5 .   ? 25.55177 -43.19415 11.76237  1.000 52.26484  ? 101 HOH A O   1 
HETATM 3863 O O   . HOH L 5 .   ? 32.466   -34.145   24.291    1.000 58.82668  ? 102 HOH A O   1 
HETATM 3864 O O   . HOH L 5 .   ? 24.65098 -37.44906 15.07856  1.000 46.61854  ? 103 HOH A O   1 
HETATM 3865 O O   . HOH L 5 .   ? 28.15542 -29.48787 11.31778  1.000 41.64802  ? 104 HOH A O   1 
HETATM 3866 O O   . HOH L 5 .   ? 11.01841 -11.88685 15.81047  1.000 62.43935  ? 105 HOH A O   1 
HETATM 3867 O O   . HOH L 5 .   ? 27.89093 -17.73667 17.48334  1.000 48.33782  ? 106 HOH A O   1 
HETATM 3868 O O   . HOH L 5 .   ? 27.36115 -38.74565 13.51202  1.000 48.96915  ? 107 HOH A O   1 
HETATM 3869 O O   . HOH L 5 .   ? 35.02697 -30.82017 21.19832  1.000 50.24700  ? 108 HOH A O   1 
HETATM 3870 O O   . HOH L 5 .   ? 29.01731 -31.97090 11.21748  1.000 48.27949  ? 109 HOH A O   1 
HETATM 3871 O O   . HOH L 5 .   ? 29.28493 -20.91350 19.52197  1.000 59.38377  ? 110 HOH A O   1 
HETATM 3872 O O   . HOH L 5 .   ? 21.337   -23.456   22.708    1.000 52.92011  ? 111 HOH A O   1 
HETATM 3873 O O   . HOH L 5 .   ? 27.27257 -15.44198 21.11339  1.000 55.36105  ? 112 HOH A O   1 
HETATM 3874 O O   . HOH L 5 .   ? 13.43381 -29.41514 6.16182   1.000 46.35499  ? 113 HOH A O   1 
HETATM 3875 O O   . HOH L 5 .   ? 34.91702 -30.70118 15.13986  1.000 57.77407  ? 114 HOH A O   1 
HETATM 3876 O O   . HOH L 5 .   ? 34.73705 -28.18100 14.80132  1.000 61.08276  ? 115 HOH A O   1 
HETATM 3877 O O   . HOH M 5 .   ? 17.13975 -34.33396 -11.67918 1.000 50.52708  ? 701 HOH B O   1 
HETATM 3878 O O   . HOH M 5 .   ? 19.29512 -32.69343 -0.24359  1.000 48.36789  ? 702 HOH B O   1 
HETATM 3879 O O   . HOH M 5 .   ? 17.75982 -24.67928 -12.19055 1.000 42.51514  ? 703 HOH B O   1 
HETATM 3880 O O   . HOH M 5 .   ? 17.82502 -28.28394 -18.18800 1.000 46.86151  ? 704 HOH B O   1 
HETATM 3881 O O   . HOH M 5 .   ? 30.89848 -18.55445 13.35674  1.000 43.27026  ? 705 HOH B O   1 
HETATM 3882 O O   . HOH M 5 .   ? 18.53595 -22.05917 -6.36145  1.000 40.80867  ? 706 HOH B O   1 
HETATM 3883 O O   . HOH M 5 .   ? 29.36409 -21.21246 10.19176  1.000 45.37134  ? 707 HOH B O   1 
HETATM 3884 O O   . HOH M 5 .   ? 25.34988 -29.07037 3.64855   1.000 44.13994  ? 708 HOH B O   1 
HETATM 3885 O O   . HOH M 5 .   ? 20.48684 -12.52792 25.38952  1.000 57.98096  ? 709 HOH B O   1 
HETATM 3886 O O   . HOH M 5 .   ? 28.99228 -13.52914 4.60855   1.000 42.52117  ? 710 HOH B O   1 
HETATM 3887 O O   . HOH M 5 .   ? 38.25422 -33.41069 -10.41823 1.000 45.78152  ? 711 HOH B O   1 
HETATM 3888 O O   . HOH M 5 .   ? 35.13694 -32.66309 5.17298   1.000 50.67466  ? 712 HOH B O   1 
HETATM 3889 O O   . HOH M 5 .   ? 39.79777 -36.33619 0.64011   1.000 54.00725  ? 713 HOH B O   1 
HETATM 3890 O O   . HOH M 5 .   ? 26.89539 -42.77398 -26.88726 1.000 58.13144  ? 714 HOH B O   1 
HETATM 3891 O O   . HOH M 5 .   ? 39.93822 -32.06194 -8.24099  1.000 39.76952  ? 715 HOH B O   1 
HETATM 3892 O O   . HOH M 5 .   ? 36.71285 -29.90915 -12.16511 1.000 40.31707  ? 716 HOH B O   1 
HETATM 3893 O O   . HOH M 5 .   ? 20.66962 -36.95694 -3.40780  1.000 40.32661  ? 717 HOH B O   1 
HETATM 3894 O O   . HOH M 5 .   ? 17.90491 -21.02881 -15.05460 1.000 47.61295  ? 718 HOH B O   1 
HETATM 3895 O O   . HOH M 5 .   ? 18.51242 -37.06466 9.48047   1.000 41.39763  ? 719 HOH B O   1 
HETATM 3896 O O   . HOH M 5 .   ? 29.99198 -12.18571 0.38654   1.000 52.56681  ? 720 HOH B O   1 
HETATM 3897 O O   . HOH M 5 .   ? 21.54203 -30.25466 2.93382   1.000 38.83884  ? 721 HOH B O   1 
HETATM 3898 O O   . HOH M 5 .   ? 29.91237 -21.04851 -4.76443  1.000 33.46398  ? 722 HOH B O   1 
HETATM 3899 O O   . HOH M 5 .   ? 45.51530 -34.04917 -18.24291 1.000 64.63832  ? 723 HOH B O   1 
HETATM 3900 O O   . HOH M 5 .   ? 22.52260 -27.05267 -8.67505  1.000 38.01008  ? 724 HOH B O   1 
HETATM 3901 O O   . HOH M 5 .   ? 30.79537 -39.95321 6.13982   1.000 55.12664  ? 725 HOH B O   1 
HETATM 3902 O O   . HOH M 5 .   ? 27.84734 -15.67671 2.71224   1.000 44.53772  ? 726 HOH B O   1 
HETATM 3903 O O   . HOH M 5 .   ? 35.48053 -14.10113 14.10327  1.000 46.77625  ? 727 HOH B O   1 
HETATM 3904 O O   . HOH M 5 .   ? 23.69626 -9.67204  13.04315  1.000 51.60176  ? 728 HOH B O   1 
HETATM 3905 O O   . HOH M 5 .   ? 19.54545 -25.95282 -9.70522  1.000 45.53766  ? 729 HOH B O   1 
HETATM 3906 O O   . HOH M 5 .   ? 15.70451 -22.63168 -9.72197  1.000 50.21485  ? 730 HOH B O   1 
HETATM 3907 O O   . HOH M 5 .   ? 21.04375 -42.01715 -8.98377  1.000 45.69687  ? 731 HOH B O   1 
HETATM 3908 O O   . HOH M 5 .   ? 27.33546 -22.56996 -9.22150  1.000 36.71265  ? 732 HOH B O   1 
HETATM 3909 O O   . HOH M 5 .   ? 37.83804 -30.67630 -7.74804  1.000 40.01184  ? 733 HOH B O   1 
HETATM 3910 O O   . HOH M 5 .   ? 28.40701 -14.14004 0.13545   1.000 37.76676  ? 734 HOH B O   1 
HETATM 3911 O O   . HOH M 5 .   ? 32.48720 -29.56091 0.12021   1.000 37.33685  ? 735 HOH B O   1 
HETATM 3912 O O   . HOH M 5 .   ? 35.19935 -43.61615 -4.04485  1.000 56.12184  ? 736 HOH B O   1 
HETATM 3913 O O   . HOH M 5 .   ? 34.57279 -47.42737 -16.10691 1.000 81.43936  ? 737 HOH B O   1 
HETATM 3914 O O   . HOH M 5 .   ? 23.78398 -14.03465 -6.55381  1.000 50.13795  ? 738 HOH B O   1 
HETATM 3915 O O   . HOH M 5 .   ? 28.96815 -16.84005 15.54357  1.000 47.68530  ? 739 HOH B O   1 
HETATM 3916 O O   . HOH M 5 .   ? 14.60433 -16.75534 -4.11005  1.000 55.42990  ? 740 HOH B O   1 
HETATM 3917 O O   . HOH M 5 .   ? 21.30960 -17.49921 4.34308   1.000 48.38220  ? 741 HOH B O   1 
HETATM 3918 O O   . HOH M 5 .   ? 20.69770 -20.07595 5.69401   1.000 45.29268  ? 742 HOH B O   1 
HETATM 3919 O O   . HOH M 5 .   ? 20.65243 -20.45939 -6.42902  1.000 38.90910  ? 743 HOH B O   1 
HETATM 3920 O O   . HOH M 5 .   ? 33.98754 -42.79960 12.91479  1.000 55.38631  ? 744 HOH B O   1 
HETATM 3921 O O   . HOH M 5 .   ? 31.25202 -7.01157  9.25265   1.000 50.25164  ? 745 HOH B O   1 
HETATM 3922 O O   . HOH M 5 .   ? 19.53921 -28.42874 2.01720   1.000 46.99489  ? 746 HOH B O   1 
HETATM 3923 O O   . HOH M 5 .   ? 38.92059 -25.38914 -6.28910  1.000 56.12536  ? 747 HOH B O   1 
HETATM 3924 O O   . HOH M 5 .   ? 34.03797 -10.02260 7.54002   1.000 50.80741  ? 748 HOH B O   1 
HETATM 3925 O O   . HOH M 5 .   ? 24.62260 -11.41382 -1.85670  1.000 48.95742  ? 749 HOH B O   1 
HETATM 3926 O O   . HOH M 5 .   ? 14.49192 -18.80014 -13.65538 1.000 56.44708  ? 750 HOH B O   1 
HETATM 3927 O O   . HOH M 5 .   ? 37.20318 -44.89200 5.57353   1.000 58.70244  ? 751 HOH B O   1 
HETATM 3928 O O   . HOH M 5 .   ? 16.80354 -31.48575 -1.41618  1.000 50.22412  ? 752 HOH B O   1 
HETATM 3929 O O   . HOH M 5 .   ? 20.84689 -38.05976 -8.20796  1.000 41.52400  ? 753 HOH B O   1 
HETATM 3930 O O   . HOH M 5 .   ? 14.20765 -27.25773 -16.18374 1.000 54.43310  ? 754 HOH B O   1 
HETATM 3931 O O   . HOH M 5 .   ? 28.27748 -12.88583 21.25249  1.000 59.13726  ? 755 HOH B O   1 
HETATM 3932 O O   . HOH M 5 .   ? 19.51116 -32.35636 2.42610   1.000 50.64681  ? 756 HOH B O   1 
HETATM 3933 O O   . HOH M 5 .   ? 32.16496 -5.51552  1.31293   1.000 65.40080  ? 757 HOH B O   1 
HETATM 3934 O O   . HOH M 5 .   ? 41.48285 -28.63875 -5.99755  1.000 50.89896  ? 758 HOH B O   1 
HETATM 3935 O O   . HOH M 5 .   ? 19.61644 -39.76800 9.31441   1.000 52.44851  ? 759 HOH B O   1 
HETATM 3936 O O   . HOH M 5 .   ? 27.79607 -11.12582 -2.59840  1.000 52.24239  ? 760 HOH B O   1 
HETATM 3937 O O   . HOH M 5 .   ? 27.44220 -11.74877 3.72666   1.000 43.59941  ? 761 HOH B O   1 
HETATM 3938 O O   . HOH M 5 .   ? 18.91793 -11.01713 23.62393  1.000 62.27312  ? 762 HOH B O   1 
HETATM 3939 O O   . HOH N 5 .   ? 46.16173 12.13080  -19.02256 1.000 53.68285  ? 201 HOH C O   1 
HETATM 3940 O O   . HOH N 5 .   ? 42.28247 0.61144   -1.78667  1.000 56.59802  ? 202 HOH C O   1 
HETATM 3941 O O   . HOH N 5 .   ? 25.46359 3.44066   -16.85159 1.000 54.50801  ? 203 HOH C O   1 
HETATM 3942 O O   . HOH N 5 .   ? 41.58675 8.60778   -28.83898 1.000 66.77216  ? 204 HOH C O   1 
HETATM 3943 O O   . HOH N 5 .   ? 44.56736 -5.16629  -2.65029  1.000 71.80431  ? 205 HOH C O   1 
HETATM 3944 O O   . HOH N 5 .   ? 44.39748 -1.96063  0.17249   1.000 60.93709  ? 206 HOH C O   1 
HETATM 3945 O O   . HOH N 5 .   ? 39.62637 -3.85185  -9.41349  1.000 39.92624  ? 207 HOH C O   1 
HETATM 3946 O O   . HOH N 5 .   ? 27.931   0.135     -16.936   1.000 54.47662  ? 208 HOH C O   1 
HETATM 3947 O O   . HOH N 5 .   ? 55.32424 4.93595   -7.55218  1.000 72.93711  ? 209 HOH C O   1 
HETATM 3948 O O   . HOH N 5 .   ? 37.89771 -5.40099  -9.72759  1.000 41.54044  ? 210 HOH C O   1 
HETATM 3949 O O   . HOH N 5 .   ? 29.91986 -0.36702  -14.73661 1.000 41.40897  ? 211 HOH C O   1 
HETATM 3950 O O   . HOH N 5 .   ? 26.588   2.315     -21.531   1.000 56.10498  ? 212 HOH C O   1 
HETATM 3951 O O   . HOH N 5 .   ? 25.29164 2.24416   -18.87758 1.000 57.07925  ? 213 HOH C O   1 
HETATM 3952 O O   . HOH O 5 .   ? 49.10510 6.68867   15.11215  1.000 58.36776  ? 701 HOH D O   1 
HETATM 3953 O O   . HOH O 5 .   ? 29.88898 15.25840  10.80429  1.000 41.15547  ? 702 HOH D O   1 
HETATM 3954 O O   . HOH O 5 .   ? 39.00611 -1.78566  1.19102   1.000 47.56932  ? 703 HOH D O   1 
HETATM 3955 O O   . HOH O 5 .   ? 22.89094 23.16941  0.06216   1.000 63.79293  ? 704 HOH D O   1 
HETATM 3956 O O   . HOH O 5 .   ? 36.35606 0.15239   12.22661  1.000 52.15294  ? 705 HOH D O   1 
HETATM 3957 O O   . HOH O 5 .   ? 36.03824 11.56683  15.17330  1.000 42.61959  ? 706 HOH D O   1 
HETATM 3958 O O   . HOH O 5 .   ? 30.62230 6.85690   -14.44436 1.000 51.12797  ? 707 HOH D O   1 
HETATM 3959 O O   . HOH O 5 .   ? 52.99954 16.22636  -7.12343  1.000 56.34917  ? 708 HOH D O   1 
HETATM 3960 O O   . HOH O 5 .   ? 42.23005 11.83127  8.16681   1.000 46.31225  ? 709 HOH D O   1 
HETATM 3961 O O   . HOH O 5 .   ? 45.28187 9.23464   19.25144  1.000 56.38732  ? 710 HOH D O   1 
HETATM 3962 O O   . HOH O 5 .   ? 29.32621 14.72654  6.45528   1.000 41.63277  ? 711 HOH D O   1 
HETATM 3963 O O   . HOH O 5 .   ? 52.10576 7.37341   -2.68123  1.000 58.47355  ? 712 HOH D O   1 
HETATM 3964 O O   . HOH O 5 .   ? 22.68634 17.92957  4.31223   1.000 61.67469  ? 713 HOH D O   1 
HETATM 3965 O O   . HOH O 5 .   ? 27.05683 -0.04270  -12.26488 1.000 50.94307  ? 714 HOH D O   1 
HETATM 3966 O O   . HOH O 5 .   ? 25.56222 3.07132   -5.96381  1.000 49.95649  ? 715 HOH D O   1 
HETATM 3967 O O   . HOH O 5 .   ? 41.44465 14.27567  3.68283   1.000 36.85346  ? 716 HOH D O   1 
HETATM 3968 O O   . HOH O 5 .   ? 55.03359 13.08187  -13.66099 1.000 58.32886  ? 717 HOH D O   1 
HETATM 3969 O O   . HOH O 5 .   ? 19.54987 11.41911  18.55031  1.000 52.55521  ? 718 HOH D O   1 
HETATM 3970 O O   . HOH O 5 .   ? 37.88832 -3.29159  -7.12167  1.000 42.70800  ? 719 HOH D O   1 
HETATM 3971 O O   . HOH O 5 .   ? 42.41863 13.64209  0.79893   1.000 40.92557  ? 720 HOH D O   1 
HETATM 3972 O O   . HOH O 5 .   ? 37.79521 5.03393   -4.12273  1.000 44.08771  ? 721 HOH D O   1 
HETATM 3973 O O   . HOH O 5 .   ? 42.83745 2.00985   18.81616  1.000 53.90281  ? 722 HOH D O   1 
HETATM 3974 O O   . HOH O 5 .   ? 41.31800 5.11721   8.38841   1.000 45.16778  ? 723 HOH D O   1 
HETATM 3975 O O   . HOH O 5 .   ? 48.85752 16.78233  -5.33757  1.000 49.63418  ? 724 HOH D O   1 
HETATM 3976 O O   . HOH O 5 .   ? 32.98817 10.75000  -0.64925  1.000 44.35333  ? 725 HOH D O   1 
HETATM 3977 O O   . HOH O 5 .   ? 17.22382 16.45149  28.15908  1.000 53.60544  ? 726 HOH D O   1 
HETATM 3978 O O   . HOH O 5 .   ? 36.47679 4.23562   -6.32509  1.000 38.44501  ? 727 HOH D O   1 
HETATM 3979 O O   . HOH O 5 .   ? 26.76433 14.17570  9.14632   1.000 46.51971  ? 728 HOH D O   1 
HETATM 3980 O O   . HOH O 5 .   ? 36.00663 12.24278  -11.57049 1.000 50.41834  ? 729 HOH D O   1 
HETATM 3981 O O   . HOH O 5 .   ? 52.04980 21.76366  -11.05719 1.000 51.40641  ? 730 HOH D O   1 
HETATM 3982 O O   . HOH O 5 .   ? 47.39420 14.91219  -3.79162  1.000 44.80486  ? 731 HOH D O   1 
HETATM 3983 O O   . HOH O 5 .   ? 41.26484 -5.92884  7.52586   1.000 52.81761  ? 732 HOH D O   1 
HETATM 3984 O O   . HOH O 5 .   ? 51.57437 19.50087  -16.35856 1.000 54.74768  ? 733 HOH D O   1 
HETATM 3985 O O   . HOH O 5 .   ? 29.42722 10.30783  -5.75565  1.000 43.15670  ? 734 HOH D O   1 
HETATM 3986 O O   . HOH O 5 .   ? 12.06776 8.84684   16.43930  1.000 79.19934  ? 735 HOH D O   1 
HETATM 3987 O O   . HOH O 5 .   ? 49.99561 7.97025   -4.87739  1.000 55.47991  ? 736 HOH D O   1 
HETATM 3988 O O   . HOH O 5 .   ? 38.54310 14.71962  33.18703  1.000 48.66291  ? 737 HOH D O   1 
HETATM 3989 O O   . HOH O 5 .   ? 39.39271 1.55585   -2.99547  1.000 44.35413  ? 738 HOH D O   1 
HETATM 3990 O O   . HOH O 5 .   ? 26.72033 19.41772  21.12675  1.000 47.82029  ? 739 HOH D O   1 
HETATM 3991 O O   . HOH O 5 .   ? 19.60458 -3.34087  16.93817  1.000 63.07426  ? 740 HOH D O   1 
HETATM 3992 O O   . HOH O 5 .   ? 55.82850 23.12989  -18.32718 1.000 50.39716  ? 741 HOH D O   1 
HETATM 3993 O O   . HOH O 5 .   ? 47.85850 6.17886   -5.92851  1.000 52.52179  ? 742 HOH D O   1 
HETATM 3994 O O   . HOH O 5 .   ? 49.52170 6.06558   11.97841  1.000 60.07637  ? 743 HOH D O   1 
HETATM 3995 O O   . HOH O 5 .   ? 43.39091 11.01647  27.69470  1.000 53.73920  ? 744 HOH D O   1 
HETATM 3996 O O   . HOH O 5 .   ? 33.37474 -3.37759  8.93210   1.000 51.74216  ? 745 HOH D O   1 
HETATM 3997 O O   . HOH O 5 .   ? 39.61807 19.34439  15.98096  1.000 46.00399  ? 746 HOH D O   1 
HETATM 3998 O O   . HOH O 5 .   ? 36.97257 -5.02790  1.56337   1.000 49.58047  ? 747 HOH D O   1 
HETATM 3999 O O   . HOH O 5 .   ? 33.53187 15.66558  35.21608  1.000 45.77564  ? 748 HOH D O   1 
HETATM 4000 O O   . HOH O 5 .   ? 26.552   0.885     35.310    1.000 62.16817  ? 749 HOH D O   1 
HETATM 4001 O O   . HOH O 5 .   ? 26.86284 19.60352  11.32505  1.000 63.71457  ? 750 HOH D O   1 
HETATM 4002 O O   . HOH O 5 .   ? 49.17765 18.75444  0.86514   1.000 49.20170  ? 751 HOH D O   1 
HETATM 4003 O O   . HOH O 5 .   ? 37.27053 21.86705  25.31508  1.000 55.42867  ? 752 HOH D O   1 
HETATM 4004 O O   . HOH O 5 .   ? 50.78622 4.35796   6.86819   1.000 51.75429  ? 753 HOH D O   1 
HETATM 4005 O O   . HOH O 5 .   ? 17.558   23.700    27.185    1.000 60.67687  ? 754 HOH D O   1 
HETATM 4006 O O   . HOH O 5 .   ? 24.908   -1.772    -15.480   1.000 50.75583  ? 755 HOH D O   1 
HETATM 4007 O O   . HOH O 5 .   ? 36.59703 -3.13121  10.93799  1.000 54.23137  ? 756 HOH D O   1 
HETATM 4008 O O   . HOH O 5 .   ? 27.65662 18.73722  1.16579   1.000 62.25279  ? 757 HOH D O   1 
HETATM 4009 O O   . HOH O 5 .   ? 52.68432 22.12653  -19.19870 1.000 66.67495  ? 758 HOH D O   1 
HETATM 4010 O O   . HOH O 5 .   ? 29.89462 -4.29450  2.93247   1.000 55.56672  ? 759 HOH D O   1 
HETATM 4011 O O   . HOH O 5 .   ? 32.57030 -3.94675  6.51116   1.000 46.68249  ? 760 HOH D O   1 
HETATM 4012 O O   . HOH O 5 .   ? 50.35953 7.06848   9.79268   1.000 64.16925  ? 761 HOH D O   1 
HETATM 4013 O O   . HOH O 5 .   ? 37.96166 18.85433  10.91939  1.000 48.24883  ? 762 HOH D O   1 
HETATM 4014 O O   . HOH O 5 .   ? 39.38217 19.82403  12.47824  1.000 50.39042  ? 763 HOH D O   1 
HETATM 4015 O O   . HOH O 5 .   ? 29.45325 -5.14851  6.11788   1.000 51.65345  ? 764 HOH D O   1 
HETATM 4016 O O   . HOH O 5 .   ? 36.44077 13.15407  33.79257  1.000 57.21348  ? 765 HOH D O   1 
HETATM 4017 O O   . HOH O 5 .   ? 46.51129 10.60831  16.70900  1.000 64.16876  ? 766 HOH D O   1 
HETATM 4018 O O   . HOH O 5 .   ? 53.53246 2.97112   7.61095   1.000 56.54165  ? 767 HOH D O   1 
# 
