data_8Y9S
# 
_entry.id   8Y9S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Y9S         pdb_00008y9s 10.2210/pdb8y9s/pdb 
WWPDB D_1300045099 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-02-26 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Derived calculations' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' pdbx_struct_assembly      
2 2 'Structure model' pdbx_struct_assembly_gen  
3 2 'Structure model' pdbx_struct_assembly_prop 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Y9S 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yuding@fudan.edu.cn 
_pdbx_contact_author.name_first         Yu 
_pdbx_contact_author.name_last          Ding 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7772-6449 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ding, Y.'    1 0000-0001-7772-6449 
'Zhong, P.Y.' 2 0000-0002-3250-7645 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of nanobody MY6321 bound to human serum albumin (HSA)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ding, Y.'    1 0000-0001-7772-6449 
primary 'Zhong, P.Y.' 2 0000-0002-3250-7645 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Albumin           67346.156 2 ? ? ? ? 
2 polymer man 'nanobody MY6321' 13138.754 2 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        HSA 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;RGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKL
CTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPEL
LFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKL
VTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKD
VCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCEL
FEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVT
KCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAF
VEKCCKADDKETCFAEEGKKLVAASQAALGL
;
;RGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKL
CTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPEL
LFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKL
VTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKD
VCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCEL
FEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVT
KCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAF
VEKCCKADDKETCFAEEGKKLVAASQAALGL
;
A,C ? 
2 'polypeptide(L)' no no 
;EVQLVESGGGLVQPGGSLRLSCTASGYMSSTYYMAWFRQPPGKGLEGVALISPYGGATNYADSVKGRFTISRDNAKNTLY
LQMNSLKPEDTARYYCAAGSTLTMVVANYRYWGQGTLVTVSS
;
;EVQLVESGGGLVQPGGSLRLSCTASGYMSSTYYMAWFRQPPGKGLEGVALISPYGGATNYADSVKGRFTISRDNAKNTLY
LQMNSLKPEDTARYYCAAGSTLTMVVANYRYWGQGTLVTVSS
;
B,D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ARG n 
1 2   GLY n 
1 3   VAL n 
1 4   PHE n 
1 5   ARG n 
1 6   ARG n 
1 7   ASP n 
1 8   ALA n 
1 9   HIS n 
1 10  LYS n 
1 11  SER n 
1 12  GLU n 
1 13  VAL n 
1 14  ALA n 
1 15  HIS n 
1 16  ARG n 
1 17  PHE n 
1 18  LYS n 
1 19  ASP n 
1 20  LEU n 
1 21  GLY n 
1 22  GLU n 
1 23  GLU n 
1 24  ASN n 
1 25  PHE n 
1 26  LYS n 
1 27  ALA n 
1 28  LEU n 
1 29  VAL n 
1 30  LEU n 
1 31  ILE n 
1 32  ALA n 
1 33  PHE n 
1 34  ALA n 
1 35  GLN n 
1 36  TYR n 
1 37  LEU n 
1 38  GLN n 
1 39  GLN n 
1 40  CYS n 
1 41  PRO n 
1 42  PHE n 
1 43  GLU n 
1 44  ASP n 
1 45  HIS n 
1 46  VAL n 
1 47  LYS n 
1 48  LEU n 
1 49  VAL n 
1 50  ASN n 
1 51  GLU n 
1 52  VAL n 
1 53  THR n 
1 54  GLU n 
1 55  PHE n 
1 56  ALA n 
1 57  LYS n 
1 58  THR n 
1 59  CYS n 
1 60  VAL n 
1 61  ALA n 
1 62  ASP n 
1 63  GLU n 
1 64  SER n 
1 65  ALA n 
1 66  GLU n 
1 67  ASN n 
1 68  CYS n 
1 69  ASP n 
1 70  LYS n 
1 71  SER n 
1 72  LEU n 
1 73  HIS n 
1 74  THR n 
1 75  LEU n 
1 76  PHE n 
1 77  GLY n 
1 78  ASP n 
1 79  LYS n 
1 80  LEU n 
1 81  CYS n 
1 82  THR n 
1 83  VAL n 
1 84  ALA n 
1 85  THR n 
1 86  LEU n 
1 87  ARG n 
1 88  GLU n 
1 89  THR n 
1 90  TYR n 
1 91  GLY n 
1 92  GLU n 
1 93  MET n 
1 94  ALA n 
1 95  ASP n 
1 96  CYS n 
1 97  CYS n 
1 98  ALA n 
1 99  LYS n 
1 100 GLN n 
1 101 GLU n 
1 102 PRO n 
1 103 GLU n 
1 104 ARG n 
1 105 ASN n 
1 106 GLU n 
1 107 CYS n 
1 108 PHE n 
1 109 LEU n 
1 110 GLN n 
1 111 HIS n 
1 112 LYS n 
1 113 ASP n 
1 114 ASP n 
1 115 ASN n 
1 116 PRO n 
1 117 ASN n 
1 118 LEU n 
1 119 PRO n 
1 120 ARG n 
1 121 LEU n 
1 122 VAL n 
1 123 ARG n 
1 124 PRO n 
1 125 GLU n 
1 126 VAL n 
1 127 ASP n 
1 128 VAL n 
1 129 MET n 
1 130 CYS n 
1 131 THR n 
1 132 ALA n 
1 133 PHE n 
1 134 HIS n 
1 135 ASP n 
1 136 ASN n 
1 137 GLU n 
1 138 GLU n 
1 139 THR n 
1 140 PHE n 
1 141 LEU n 
1 142 LYS n 
1 143 LYS n 
1 144 TYR n 
1 145 LEU n 
1 146 TYR n 
1 147 GLU n 
1 148 ILE n 
1 149 ALA n 
1 150 ARG n 
1 151 ARG n 
1 152 HIS n 
1 153 PRO n 
1 154 TYR n 
1 155 PHE n 
1 156 TYR n 
1 157 ALA n 
1 158 PRO n 
1 159 GLU n 
1 160 LEU n 
1 161 LEU n 
1 162 PHE n 
1 163 PHE n 
1 164 ALA n 
1 165 LYS n 
1 166 ARG n 
1 167 TYR n 
1 168 LYS n 
1 169 ALA n 
1 170 ALA n 
1 171 PHE n 
1 172 THR n 
1 173 GLU n 
1 174 CYS n 
1 175 CYS n 
1 176 GLN n 
1 177 ALA n 
1 178 ALA n 
1 179 ASP n 
1 180 LYS n 
1 181 ALA n 
1 182 ALA n 
1 183 CYS n 
1 184 LEU n 
1 185 LEU n 
1 186 PRO n 
1 187 LYS n 
1 188 LEU n 
1 189 ASP n 
1 190 GLU n 
1 191 LEU n 
1 192 ARG n 
1 193 ASP n 
1 194 GLU n 
1 195 GLY n 
1 196 LYS n 
1 197 ALA n 
1 198 SER n 
1 199 SER n 
1 200 ALA n 
1 201 LYS n 
1 202 GLN n 
1 203 ARG n 
1 204 LEU n 
1 205 LYS n 
1 206 CYS n 
1 207 ALA n 
1 208 SER n 
1 209 LEU n 
1 210 GLN n 
1 211 LYS n 
1 212 PHE n 
1 213 GLY n 
1 214 GLU n 
1 215 ARG n 
1 216 ALA n 
1 217 PHE n 
1 218 LYS n 
1 219 ALA n 
1 220 TRP n 
1 221 ALA n 
1 222 VAL n 
1 223 ALA n 
1 224 ARG n 
1 225 LEU n 
1 226 SER n 
1 227 GLN n 
1 228 ARG n 
1 229 PHE n 
1 230 PRO n 
1 231 LYS n 
1 232 ALA n 
1 233 GLU n 
1 234 PHE n 
1 235 ALA n 
1 236 GLU n 
1 237 VAL n 
1 238 SER n 
1 239 LYS n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 ASP n 
1 244 LEU n 
1 245 THR n 
1 246 LYS n 
1 247 VAL n 
1 248 HIS n 
1 249 THR n 
1 250 GLU n 
1 251 CYS n 
1 252 CYS n 
1 253 HIS n 
1 254 GLY n 
1 255 ASP n 
1 256 LEU n 
1 257 LEU n 
1 258 GLU n 
1 259 CYS n 
1 260 ALA n 
1 261 ASP n 
1 262 ASP n 
1 263 ARG n 
1 264 ALA n 
1 265 ASP n 
1 266 LEU n 
1 267 ALA n 
1 268 LYS n 
1 269 TYR n 
1 270 ILE n 
1 271 CYS n 
1 272 GLU n 
1 273 ASN n 
1 274 GLN n 
1 275 ASP n 
1 276 SER n 
1 277 ILE n 
1 278 SER n 
1 279 SER n 
1 280 LYS n 
1 281 LEU n 
1 282 LYS n 
1 283 GLU n 
1 284 CYS n 
1 285 CYS n 
1 286 GLU n 
1 287 LYS n 
1 288 PRO n 
1 289 LEU n 
1 290 LEU n 
1 291 GLU n 
1 292 LYS n 
1 293 SER n 
1 294 HIS n 
1 295 CYS n 
1 296 ILE n 
1 297 ALA n 
1 298 GLU n 
1 299 VAL n 
1 300 GLU n 
1 301 ASN n 
1 302 ASP n 
1 303 GLU n 
1 304 MET n 
1 305 PRO n 
1 306 ALA n 
1 307 ASP n 
1 308 LEU n 
1 309 PRO n 
1 310 SER n 
1 311 LEU n 
1 312 ALA n 
1 313 ALA n 
1 314 ASP n 
1 315 PHE n 
1 316 VAL n 
1 317 GLU n 
1 318 SER n 
1 319 LYS n 
1 320 ASP n 
1 321 VAL n 
1 322 CYS n 
1 323 LYS n 
1 324 ASN n 
1 325 TYR n 
1 326 ALA n 
1 327 GLU n 
1 328 ALA n 
1 329 LYS n 
1 330 ASP n 
1 331 VAL n 
1 332 PHE n 
1 333 LEU n 
1 334 GLY n 
1 335 MET n 
1 336 PHE n 
1 337 LEU n 
1 338 TYR n 
1 339 GLU n 
1 340 TYR n 
1 341 ALA n 
1 342 ARG n 
1 343 ARG n 
1 344 HIS n 
1 345 PRO n 
1 346 ASP n 
1 347 TYR n 
1 348 SER n 
1 349 VAL n 
1 350 VAL n 
1 351 LEU n 
1 352 LEU n 
1 353 LEU n 
1 354 ARG n 
1 355 LEU n 
1 356 ALA n 
1 357 LYS n 
1 358 THR n 
1 359 TYR n 
1 360 GLU n 
1 361 THR n 
1 362 THR n 
1 363 LEU n 
1 364 GLU n 
1 365 LYS n 
1 366 CYS n 
1 367 CYS n 
1 368 ALA n 
1 369 ALA n 
1 370 ALA n 
1 371 ASP n 
1 372 PRO n 
1 373 HIS n 
1 374 GLU n 
1 375 CYS n 
1 376 TYR n 
1 377 ALA n 
1 378 LYS n 
1 379 VAL n 
1 380 PHE n 
1 381 ASP n 
1 382 GLU n 
1 383 PHE n 
1 384 LYS n 
1 385 PRO n 
1 386 LEU n 
1 387 VAL n 
1 388 GLU n 
1 389 GLU n 
1 390 PRO n 
1 391 GLN n 
1 392 ASN n 
1 393 LEU n 
1 394 ILE n 
1 395 LYS n 
1 396 GLN n 
1 397 ASN n 
1 398 CYS n 
1 399 GLU n 
1 400 LEU n 
1 401 PHE n 
1 402 GLU n 
1 403 GLN n 
1 404 LEU n 
1 405 GLY n 
1 406 GLU n 
1 407 TYR n 
1 408 LYS n 
1 409 PHE n 
1 410 GLN n 
1 411 ASN n 
1 412 ALA n 
1 413 LEU n 
1 414 LEU n 
1 415 VAL n 
1 416 ARG n 
1 417 TYR n 
1 418 THR n 
1 419 LYS n 
1 420 LYS n 
1 421 VAL n 
1 422 PRO n 
1 423 GLN n 
1 424 VAL n 
1 425 SER n 
1 426 THR n 
1 427 PRO n 
1 428 THR n 
1 429 LEU n 
1 430 VAL n 
1 431 GLU n 
1 432 VAL n 
1 433 SER n 
1 434 ARG n 
1 435 ASN n 
1 436 LEU n 
1 437 GLY n 
1 438 LYS n 
1 439 VAL n 
1 440 GLY n 
1 441 SER n 
1 442 LYS n 
1 443 CYS n 
1 444 CYS n 
1 445 LYS n 
1 446 HIS n 
1 447 PRO n 
1 448 GLU n 
1 449 ALA n 
1 450 LYS n 
1 451 ARG n 
1 452 MET n 
1 453 PRO n 
1 454 CYS n 
1 455 ALA n 
1 456 GLU n 
1 457 ASP n 
1 458 TYR n 
1 459 LEU n 
1 460 SER n 
1 461 VAL n 
1 462 VAL n 
1 463 LEU n 
1 464 ASN n 
1 465 GLN n 
1 466 LEU n 
1 467 CYS n 
1 468 VAL n 
1 469 LEU n 
1 470 HIS n 
1 471 GLU n 
1 472 LYS n 
1 473 THR n 
1 474 PRO n 
1 475 VAL n 
1 476 SER n 
1 477 ASP n 
1 478 ARG n 
1 479 VAL n 
1 480 THR n 
1 481 LYS n 
1 482 CYS n 
1 483 CYS n 
1 484 THR n 
1 485 GLU n 
1 486 SER n 
1 487 LEU n 
1 488 VAL n 
1 489 ASN n 
1 490 ARG n 
1 491 ARG n 
1 492 PRO n 
1 493 CYS n 
1 494 PHE n 
1 495 SER n 
1 496 ALA n 
1 497 LEU n 
1 498 GLU n 
1 499 VAL n 
1 500 ASP n 
1 501 GLU n 
1 502 THR n 
1 503 TYR n 
1 504 VAL n 
1 505 PRO n 
1 506 LYS n 
1 507 GLU n 
1 508 PHE n 
1 509 ASN n 
1 510 ALA n 
1 511 GLU n 
1 512 THR n 
1 513 PHE n 
1 514 THR n 
1 515 PHE n 
1 516 HIS n 
1 517 ALA n 
1 518 ASP n 
1 519 ILE n 
1 520 CYS n 
1 521 THR n 
1 522 LEU n 
1 523 SER n 
1 524 GLU n 
1 525 LYS n 
1 526 GLU n 
1 527 ARG n 
1 528 GLN n 
1 529 ILE n 
1 530 LYS n 
1 531 LYS n 
1 532 GLN n 
1 533 THR n 
1 534 ALA n 
1 535 LEU n 
1 536 VAL n 
1 537 GLU n 
1 538 LEU n 
1 539 VAL n 
1 540 LYS n 
1 541 HIS n 
1 542 LYS n 
1 543 PRO n 
1 544 LYS n 
1 545 ALA n 
1 546 THR n 
1 547 LYS n 
1 548 GLU n 
1 549 GLN n 
1 550 LEU n 
1 551 LYS n 
1 552 ALA n 
1 553 VAL n 
1 554 MET n 
1 555 ASP n 
1 556 ASP n 
1 557 PHE n 
1 558 ALA n 
1 559 ALA n 
1 560 PHE n 
1 561 VAL n 
1 562 GLU n 
1 563 LYS n 
1 564 CYS n 
1 565 CYS n 
1 566 LYS n 
1 567 ALA n 
1 568 ASP n 
1 569 ASP n 
1 570 LYS n 
1 571 GLU n 
1 572 THR n 
1 573 CYS n 
1 574 PHE n 
1 575 ALA n 
1 576 GLU n 
1 577 GLU n 
1 578 GLY n 
1 579 LYS n 
1 580 LYS n 
1 581 LEU n 
1 582 VAL n 
1 583 ALA n 
1 584 ALA n 
1 585 SER n 
1 586 GLN n 
1 587 ALA n 
1 588 ALA n 
1 589 LEU n 
1 590 GLY n 
1 591 LEU n 
2 1   GLU n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   VAL n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  LEU n 
2 12  VAL n 
2 13  GLN n 
2 14  PRO n 
2 15  GLY n 
2 16  GLY n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  THR n 
2 24  ALA n 
2 25  SER n 
2 26  GLY n 
2 27  TYR n 
2 28  MET n 
2 29  SER n 
2 30  SER n 
2 31  THR n 
2 32  TYR n 
2 33  TYR n 
2 34  MET n 
2 35  ALA n 
2 36  TRP n 
2 37  PHE n 
2 38  ARG n 
2 39  GLN n 
2 40  PRO n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLY n 
2 45  LEU n 
2 46  GLU n 
2 47  GLY n 
2 48  VAL n 
2 49  ALA n 
2 50  LEU n 
2 51  ILE n 
2 52  SER n 
2 53  PRO n 
2 54  TYR n 
2 55  GLY n 
2 56  GLY n 
2 57  ALA n 
2 58  THR n 
2 59  ASN n 
2 60  TYR n 
2 61  ALA n 
2 62  ASP n 
2 63  SER n 
2 64  VAL n 
2 65  LYS n 
2 66  GLY n 
2 67  ARG n 
2 68  PHE n 
2 69  THR n 
2 70  ILE n 
2 71  SER n 
2 72  ARG n 
2 73  ASP n 
2 74  ASN n 
2 75  ALA n 
2 76  LYS n 
2 77  ASN n 
2 78  THR n 
2 79  LEU n 
2 80  TYR n 
2 81  LEU n 
2 82  GLN n 
2 83  MET n 
2 84  ASN n 
2 85  SER n 
2 86  LEU n 
2 87  LYS n 
2 88  PRO n 
2 89  GLU n 
2 90  ASP n 
2 91  THR n 
2 92  ALA n 
2 93  ARG n 
2 94  TYR n 
2 95  TYR n 
2 96  CYS n 
2 97  ALA n 
2 98  ALA n 
2 99  GLY n 
2 100 SER n 
2 101 THR n 
2 102 LEU n 
2 103 THR n 
2 104 MET n 
2 105 VAL n 
2 106 VAL n 
2 107 ALA n 
2 108 ASN n 
2 109 TYR n 
2 110 ARG n 
2 111 TYR n 
2 112 TRP n 
2 113 GLY n 
2 114 GLN n 
2 115 GLY n 
2 116 THR n 
2 117 LEU n 
2 118 VAL n 
2 119 THR n 
2 120 VAL n 
2 121 SER n 
2 122 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 591 human ? ALB ? ? ? ? ? ? 'Homo sapiens'  9606  ? ? ? ? ? ? ? ? 'Oryza sativa'             
4530 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 122 ?     ? ?   ? ? ? ? ? ? 'Vicugna pacos' 30538 ? ? ? ? ? ? ? ? 'Saccharomyces cerevisiae' 
4932 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ARG 1   -5  ?   ?   ?   A . n 
A 1 2   GLY 2   -4  ?   ?   ?   A . n 
A 1 3   VAL 3   -3  ?   ?   ?   A . n 
A 1 4   PHE 4   -2  ?   ?   ?   A . n 
A 1 5   ARG 5   -1  ?   ?   ?   A . n 
A 1 6   ARG 6   0   ?   ?   ?   A . n 
A 1 7   ASP 7   1   ?   ?   ?   A . n 
A 1 8   ALA 8   2   ?   ?   ?   A . n 
A 1 9   HIS 9   3   3   HIS HIS A . n 
A 1 10  LYS 10  4   4   LYS LYS A . n 
A 1 11  SER 11  5   5   SER SER A . n 
A 1 12  GLU 12  6   6   GLU GLU A . n 
A 1 13  VAL 13  7   7   VAL VAL A . n 
A 1 14  ALA 14  8   8   ALA ALA A . n 
A 1 15  HIS 15  9   9   HIS HIS A . n 
A 1 16  ARG 16  10  10  ARG ARG A . n 
A 1 17  PHE 17  11  11  PHE PHE A . n 
A 1 18  LYS 18  12  12  LYS LYS A . n 
A 1 19  ASP 19  13  13  ASP ASP A . n 
A 1 20  LEU 20  14  14  LEU LEU A . n 
A 1 21  GLY 21  15  15  GLY GLY A . n 
A 1 22  GLU 22  16  16  GLU GLU A . n 
A 1 23  GLU 23  17  17  GLU GLU A . n 
A 1 24  ASN 24  18  18  ASN ASN A . n 
A 1 25  PHE 25  19  19  PHE PHE A . n 
A 1 26  LYS 26  20  20  LYS LYS A . n 
A 1 27  ALA 27  21  21  ALA ALA A . n 
A 1 28  LEU 28  22  22  LEU LEU A . n 
A 1 29  VAL 29  23  23  VAL VAL A . n 
A 1 30  LEU 30  24  24  LEU LEU A . n 
A 1 31  ILE 31  25  25  ILE ILE A . n 
A 1 32  ALA 32  26  26  ALA ALA A . n 
A 1 33  PHE 33  27  27  PHE PHE A . n 
A 1 34  ALA 34  28  28  ALA ALA A . n 
A 1 35  GLN 35  29  29  GLN GLN A . n 
A 1 36  TYR 36  30  30  TYR TYR A . n 
A 1 37  LEU 37  31  31  LEU LEU A . n 
A 1 38  GLN 38  32  32  GLN GLN A . n 
A 1 39  GLN 39  33  33  GLN GLN A . n 
A 1 40  CYS 40  34  34  CYS CYS A . n 
A 1 41  PRO 41  35  35  PRO PRO A . n 
A 1 42  PHE 42  36  36  PHE PHE A . n 
A 1 43  GLU 43  37  37  GLU GLU A . n 
A 1 44  ASP 44  38  38  ASP ASP A . n 
A 1 45  HIS 45  39  39  HIS HIS A . n 
A 1 46  VAL 46  40  40  VAL VAL A . n 
A 1 47  LYS 47  41  41  LYS LYS A . n 
A 1 48  LEU 48  42  42  LEU LEU A . n 
A 1 49  VAL 49  43  43  VAL VAL A . n 
A 1 50  ASN 50  44  44  ASN ASN A . n 
A 1 51  GLU 51  45  45  GLU GLU A . n 
A 1 52  VAL 52  46  46  VAL VAL A . n 
A 1 53  THR 53  47  47  THR THR A . n 
A 1 54  GLU 54  48  48  GLU GLU A . n 
A 1 55  PHE 55  49  49  PHE PHE A . n 
A 1 56  ALA 56  50  50  ALA ALA A . n 
A 1 57  LYS 57  51  51  LYS LYS A . n 
A 1 58  THR 58  52  52  THR THR A . n 
A 1 59  CYS 59  53  53  CYS CYS A . n 
A 1 60  VAL 60  54  54  VAL VAL A . n 
A 1 61  ALA 61  55  55  ALA ALA A . n 
A 1 62  ASP 62  56  56  ASP ASP A . n 
A 1 63  GLU 63  57  57  GLU GLU A . n 
A 1 64  SER 64  58  58  SER SER A . n 
A 1 65  ALA 65  59  59  ALA ALA A . n 
A 1 66  GLU 66  60  60  GLU GLU A . n 
A 1 67  ASN 67  61  61  ASN ASN A . n 
A 1 68  CYS 68  62  62  CYS CYS A . n 
A 1 69  ASP 69  63  63  ASP ASP A . n 
A 1 70  LYS 70  64  64  LYS LYS A . n 
A 1 71  SER 71  65  65  SER SER A . n 
A 1 72  LEU 72  66  66  LEU LEU A . n 
A 1 73  HIS 73  67  67  HIS HIS A . n 
A 1 74  THR 74  68  68  THR THR A . n 
A 1 75  LEU 75  69  69  LEU LEU A . n 
A 1 76  PHE 76  70  70  PHE PHE A . n 
A 1 77  GLY 77  71  71  GLY GLY A . n 
A 1 78  ASP 78  72  72  ASP ASP A . n 
A 1 79  LYS 79  73  73  LYS LYS A . n 
A 1 80  LEU 80  74  74  LEU LEU A . n 
A 1 81  CYS 81  75  75  CYS CYS A . n 
A 1 82  THR 82  76  76  THR THR A . n 
A 1 83  VAL 83  77  77  VAL VAL A . n 
A 1 84  ALA 84  78  ?   ?   ?   A . n 
A 1 85  THR 85  79  79  THR THR A . n 
A 1 86  LEU 86  80  80  LEU LEU A . n 
A 1 87  ARG 87  81  81  ARG ARG A . n 
A 1 88  GLU 88  82  82  GLU GLU A . n 
A 1 89  THR 89  83  ?   ?   ?   A . n 
A 1 90  TYR 90  84  ?   ?   ?   A . n 
A 1 91  GLY 91  85  ?   ?   ?   A . n 
A 1 92  GLU 92  86  ?   ?   ?   A . n 
A 1 93  MET 93  87  87  MET MET A . n 
A 1 94  ALA 94  88  88  ALA ALA A . n 
A 1 95  ASP 95  89  89  ASP ASP A . n 
A 1 96  CYS 96  90  90  CYS CYS A . n 
A 1 97  CYS 97  91  91  CYS CYS A . n 
A 1 98  ALA 98  92  92  ALA ALA A . n 
A 1 99  LYS 99  93  93  LYS LYS A . n 
A 1 100 GLN 100 94  94  GLN GLN A . n 
A 1 101 GLU 101 95  95  GLU GLU A . n 
A 1 102 PRO 102 96  96  PRO PRO A . n 
A 1 103 GLU 103 97  ?   ?   ?   A . n 
A 1 104 ARG 104 98  ?   ?   ?   A . n 
A 1 105 ASN 105 99  99  ASN ASN A . n 
A 1 106 GLU 106 100 100 GLU GLU A . n 
A 1 107 CYS 107 101 101 CYS CYS A . n 
A 1 108 PHE 108 102 102 PHE PHE A . n 
A 1 109 LEU 109 103 103 LEU LEU A . n 
A 1 110 GLN 110 104 104 GLN GLN A . n 
A 1 111 HIS 111 105 105 HIS HIS A . n 
A 1 112 LYS 112 106 106 LYS LYS A . n 
A 1 113 ASP 113 107 107 ASP ASP A . n 
A 1 114 ASP 114 108 108 ASP ASP A . n 
A 1 115 ASN 115 109 109 ASN ASN A . n 
A 1 116 PRO 116 110 ?   ?   ?   A . n 
A 1 117 ASN 117 111 111 ASN ASN A . n 
A 1 118 LEU 118 112 112 LEU LEU A . n 
A 1 119 PRO 119 113 113 PRO PRO A . n 
A 1 120 ARG 120 114 114 ARG ARG A . n 
A 1 121 LEU 121 115 115 LEU LEU A . n 
A 1 122 VAL 122 116 116 VAL VAL A . n 
A 1 123 ARG 123 117 117 ARG ARG A . n 
A 1 124 PRO 124 118 118 PRO PRO A . n 
A 1 125 GLU 125 119 119 GLU GLU A . n 
A 1 126 VAL 126 120 120 VAL VAL A . n 
A 1 127 ASP 127 121 121 ASP ASP A . n 
A 1 128 VAL 128 122 122 VAL VAL A . n 
A 1 129 MET 129 123 123 MET MET A . n 
A 1 130 CYS 130 124 124 CYS CYS A . n 
A 1 131 THR 131 125 125 THR THR A . n 
A 1 132 ALA 132 126 126 ALA ALA A . n 
A 1 133 PHE 133 127 127 PHE PHE A . n 
A 1 134 HIS 134 128 128 HIS HIS A . n 
A 1 135 ASP 135 129 129 ASP ASP A . n 
A 1 136 ASN 136 130 130 ASN ASN A . n 
A 1 137 GLU 137 131 131 GLU GLU A . n 
A 1 138 GLU 138 132 132 GLU GLU A . n 
A 1 139 THR 139 133 133 THR THR A . n 
A 1 140 PHE 140 134 134 PHE PHE A . n 
A 1 141 LEU 141 135 135 LEU LEU A . n 
A 1 142 LYS 142 136 136 LYS LYS A . n 
A 1 143 LYS 143 137 137 LYS LYS A . n 
A 1 144 TYR 144 138 138 TYR TYR A . n 
A 1 145 LEU 145 139 139 LEU LEU A . n 
A 1 146 TYR 146 140 140 TYR TYR A . n 
A 1 147 GLU 147 141 141 GLU GLU A . n 
A 1 148 ILE 148 142 142 ILE ILE A . n 
A 1 149 ALA 149 143 143 ALA ALA A . n 
A 1 150 ARG 150 144 144 ARG ARG A . n 
A 1 151 ARG 151 145 145 ARG ARG A . n 
A 1 152 HIS 152 146 146 HIS HIS A . n 
A 1 153 PRO 153 147 147 PRO PRO A . n 
A 1 154 TYR 154 148 148 TYR TYR A . n 
A 1 155 PHE 155 149 149 PHE PHE A . n 
A 1 156 TYR 156 150 150 TYR TYR A . n 
A 1 157 ALA 157 151 151 ALA ALA A . n 
A 1 158 PRO 158 152 152 PRO PRO A . n 
A 1 159 GLU 159 153 153 GLU GLU A . n 
A 1 160 LEU 160 154 154 LEU LEU A . n 
A 1 161 LEU 161 155 155 LEU LEU A . n 
A 1 162 PHE 162 156 156 PHE PHE A . n 
A 1 163 PHE 163 157 157 PHE PHE A . n 
A 1 164 ALA 164 158 158 ALA ALA A . n 
A 1 165 LYS 165 159 159 LYS LYS A . n 
A 1 166 ARG 166 160 160 ARG ARG A . n 
A 1 167 TYR 167 161 161 TYR TYR A . n 
A 1 168 LYS 168 162 162 LYS LYS A . n 
A 1 169 ALA 169 163 163 ALA ALA A . n 
A 1 170 ALA 170 164 164 ALA ALA A . n 
A 1 171 PHE 171 165 165 PHE PHE A . n 
A 1 172 THR 172 166 166 THR THR A . n 
A 1 173 GLU 173 167 167 GLU GLU A . n 
A 1 174 CYS 174 168 168 CYS CYS A . n 
A 1 175 CYS 175 169 169 CYS CYS A . n 
A 1 176 GLN 176 170 ?   ?   ?   A . n 
A 1 177 ALA 177 171 ?   ?   ?   A . n 
A 1 178 ALA 178 172 ?   ?   ?   A . n 
A 1 179 ASP 179 173 ?   ?   ?   A . n 
A 1 180 LYS 180 174 ?   ?   ?   A . n 
A 1 181 ALA 181 175 ?   ?   ?   A . n 
A 1 182 ALA 182 176 176 ALA ALA A . n 
A 1 183 CYS 183 177 177 CYS CYS A . n 
A 1 184 LEU 184 178 ?   ?   ?   A . n 
A 1 185 LEU 185 179 179 LEU LEU A . n 
A 1 186 PRO 186 180 180 PRO PRO A . n 
A 1 187 LYS 187 181 181 LYS LYS A . n 
A 1 188 LEU 188 182 182 LEU LEU A . n 
A 1 189 ASP 189 183 183 ASP ASP A . n 
A 1 190 GLU 190 184 184 GLU GLU A . n 
A 1 191 LEU 191 185 185 LEU LEU A . n 
A 1 192 ARG 192 186 186 ARG ARG A . n 
A 1 193 ASP 193 187 187 ASP ASP A . n 
A 1 194 GLU 194 188 188 GLU GLU A . n 
A 1 195 GLY 195 189 189 GLY GLY A . n 
A 1 196 LYS 196 190 190 LYS LYS A . n 
A 1 197 ALA 197 191 191 ALA ALA A . n 
A 1 198 SER 198 192 192 SER SER A . n 
A 1 199 SER 199 193 193 SER SER A . n 
A 1 200 ALA 200 194 194 ALA ALA A . n 
A 1 201 LYS 201 195 195 LYS LYS A . n 
A 1 202 GLN 202 196 196 GLN GLN A . n 
A 1 203 ARG 203 197 197 ARG ARG A . n 
A 1 204 LEU 204 198 198 LEU LEU A . n 
A 1 205 LYS 205 199 199 LYS LYS A . n 
A 1 206 CYS 206 200 200 CYS CYS A . n 
A 1 207 ALA 207 201 201 ALA ALA A . n 
A 1 208 SER 208 202 202 SER SER A . n 
A 1 209 LEU 209 203 203 LEU LEU A . n 
A 1 210 GLN 210 204 204 GLN GLN A . n 
A 1 211 LYS 211 205 205 LYS LYS A . n 
A 1 212 PHE 212 206 206 PHE PHE A . n 
A 1 213 GLY 213 207 207 GLY GLY A . n 
A 1 214 GLU 214 208 208 GLU GLU A . n 
A 1 215 ARG 215 209 209 ARG ARG A . n 
A 1 216 ALA 216 210 210 ALA ALA A . n 
A 1 217 PHE 217 211 211 PHE PHE A . n 
A 1 218 LYS 218 212 212 LYS LYS A . n 
A 1 219 ALA 219 213 213 ALA ALA A . n 
A 1 220 TRP 220 214 214 TRP TRP A . n 
A 1 221 ALA 221 215 215 ALA ALA A . n 
A 1 222 VAL 222 216 216 VAL VAL A . n 
A 1 223 ALA 223 217 217 ALA ALA A . n 
A 1 224 ARG 224 218 218 ARG ARG A . n 
A 1 225 LEU 225 219 219 LEU LEU A . n 
A 1 226 SER 226 220 220 SER SER A . n 
A 1 227 GLN 227 221 221 GLN GLN A . n 
A 1 228 ARG 228 222 222 ARG ARG A . n 
A 1 229 PHE 229 223 223 PHE PHE A . n 
A 1 230 PRO 230 224 224 PRO PRO A . n 
A 1 231 LYS 231 225 225 LYS LYS A . n 
A 1 232 ALA 232 226 226 ALA ALA A . n 
A 1 233 GLU 233 227 227 GLU GLU A . n 
A 1 234 PHE 234 228 228 PHE PHE A . n 
A 1 235 ALA 235 229 229 ALA ALA A . n 
A 1 236 GLU 236 230 230 GLU GLU A . n 
A 1 237 VAL 237 231 231 VAL VAL A . n 
A 1 238 SER 238 232 232 SER SER A . n 
A 1 239 LYS 239 233 233 LYS LYS A . n 
A 1 240 LEU 240 234 234 LEU LEU A . n 
A 1 241 VAL 241 235 235 VAL VAL A . n 
A 1 242 THR 242 236 236 THR THR A . n 
A 1 243 ASP 243 237 237 ASP ASP A . n 
A 1 244 LEU 244 238 238 LEU LEU A . n 
A 1 245 THR 245 239 239 THR THR A . n 
A 1 246 LYS 246 240 240 LYS LYS A . n 
A 1 247 VAL 247 241 241 VAL VAL A . n 
A 1 248 HIS 248 242 242 HIS HIS A . n 
A 1 249 THR 249 243 243 THR THR A . n 
A 1 250 GLU 250 244 244 GLU GLU A . n 
A 1 251 CYS 251 245 245 CYS CYS A . n 
A 1 252 CYS 252 246 246 CYS CYS A . n 
A 1 253 HIS 253 247 247 HIS HIS A . n 
A 1 254 GLY 254 248 248 GLY GLY A . n 
A 1 255 ASP 255 249 249 ASP ASP A . n 
A 1 256 LEU 256 250 250 LEU LEU A . n 
A 1 257 LEU 257 251 251 LEU LEU A . n 
A 1 258 GLU 258 252 252 GLU GLU A . n 
A 1 259 CYS 259 253 253 CYS CYS A . n 
A 1 260 ALA 260 254 254 ALA ALA A . n 
A 1 261 ASP 261 255 255 ASP ASP A . n 
A 1 262 ASP 262 256 256 ASP ASP A . n 
A 1 263 ARG 263 257 257 ARG ARG A . n 
A 1 264 ALA 264 258 258 ALA ALA A . n 
A 1 265 ASP 265 259 259 ASP ASP A . n 
A 1 266 LEU 266 260 260 LEU LEU A . n 
A 1 267 ALA 267 261 261 ALA ALA A . n 
A 1 268 LYS 268 262 262 LYS LYS A . n 
A 1 269 TYR 269 263 263 TYR TYR A . n 
A 1 270 ILE 270 264 264 ILE ILE A . n 
A 1 271 CYS 271 265 265 CYS CYS A . n 
A 1 272 GLU 272 266 266 GLU GLU A . n 
A 1 273 ASN 273 267 267 ASN ASN A . n 
A 1 274 GLN 274 268 268 GLN GLN A . n 
A 1 275 ASP 275 269 269 ASP ASP A . n 
A 1 276 SER 276 270 270 SER SER A . n 
A 1 277 ILE 277 271 271 ILE ILE A . n 
A 1 278 SER 278 272 272 SER SER A . n 
A 1 279 SER 279 273 273 SER SER A . n 
A 1 280 LYS 280 274 274 LYS LYS A . n 
A 1 281 LEU 281 275 275 LEU LEU A . n 
A 1 282 LYS 282 276 276 LYS LYS A . n 
A 1 283 GLU 283 277 277 GLU GLU A . n 
A 1 284 CYS 284 278 278 CYS CYS A . n 
A 1 285 CYS 285 279 279 CYS CYS A . n 
A 1 286 GLU 286 280 280 GLU GLU A . n 
A 1 287 LYS 287 281 281 LYS LYS A . n 
A 1 288 PRO 288 282 282 PRO PRO A . n 
A 1 289 LEU 289 283 283 LEU LEU A . n 
A 1 290 LEU 290 284 284 LEU LEU A . n 
A 1 291 GLU 291 285 285 GLU GLU A . n 
A 1 292 LYS 292 286 286 LYS LYS A . n 
A 1 293 SER 293 287 287 SER SER A . n 
A 1 294 HIS 294 288 288 HIS HIS A . n 
A 1 295 CYS 295 289 289 CYS CYS A . n 
A 1 296 ILE 296 290 290 ILE ILE A . n 
A 1 297 ALA 297 291 291 ALA ALA A . n 
A 1 298 GLU 298 292 292 GLU GLU A . n 
A 1 299 VAL 299 293 293 VAL VAL A . n 
A 1 300 GLU 300 294 294 GLU GLU A . n 
A 1 301 ASN 301 295 295 ASN ASN A . n 
A 1 302 ASP 302 296 296 ASP ASP A . n 
A 1 303 GLU 303 297 297 GLU GLU A . n 
A 1 304 MET 304 298 298 MET MET A . n 
A 1 305 PRO 305 299 299 PRO PRO A . n 
A 1 306 ALA 306 300 300 ALA ALA A . n 
A 1 307 ASP 307 301 301 ASP ASP A . n 
A 1 308 LEU 308 302 302 LEU LEU A . n 
A 1 309 PRO 309 303 303 PRO PRO A . n 
A 1 310 SER 310 304 304 SER SER A . n 
A 1 311 LEU 311 305 305 LEU LEU A . n 
A 1 312 ALA 312 306 306 ALA ALA A . n 
A 1 313 ALA 313 307 307 ALA ALA A . n 
A 1 314 ASP 314 308 308 ASP ASP A . n 
A 1 315 PHE 315 309 309 PHE PHE A . n 
A 1 316 VAL 316 310 310 VAL VAL A . n 
A 1 317 GLU 317 311 311 GLU GLU A . n 
A 1 318 SER 318 312 312 SER SER A . n 
A 1 319 LYS 319 313 313 LYS LYS A . n 
A 1 320 ASP 320 314 314 ASP ASP A . n 
A 1 321 VAL 321 315 315 VAL VAL A . n 
A 1 322 CYS 322 316 316 CYS CYS A . n 
A 1 323 LYS 323 317 317 LYS LYS A . n 
A 1 324 ASN 324 318 318 ASN ASN A . n 
A 1 325 TYR 325 319 319 TYR TYR A . n 
A 1 326 ALA 326 320 320 ALA ALA A . n 
A 1 327 GLU 327 321 321 GLU GLU A . n 
A 1 328 ALA 328 322 322 ALA ALA A . n 
A 1 329 LYS 329 323 323 LYS LYS A . n 
A 1 330 ASP 330 324 324 ASP ASP A . n 
A 1 331 VAL 331 325 325 VAL VAL A . n 
A 1 332 PHE 332 326 326 PHE PHE A . n 
A 1 333 LEU 333 327 327 LEU LEU A . n 
A 1 334 GLY 334 328 328 GLY GLY A . n 
A 1 335 MET 335 329 329 MET MET A . n 
A 1 336 PHE 336 330 330 PHE PHE A . n 
A 1 337 LEU 337 331 331 LEU LEU A . n 
A 1 338 TYR 338 332 332 TYR TYR A . n 
A 1 339 GLU 339 333 333 GLU GLU A . n 
A 1 340 TYR 340 334 334 TYR TYR A . n 
A 1 341 ALA 341 335 335 ALA ALA A . n 
A 1 342 ARG 342 336 336 ARG ARG A . n 
A 1 343 ARG 343 337 337 ARG ARG A . n 
A 1 344 HIS 344 338 338 HIS HIS A . n 
A 1 345 PRO 345 339 339 PRO PRO A . n 
A 1 346 ASP 346 340 340 ASP ASP A . n 
A 1 347 TYR 347 341 341 TYR TYR A . n 
A 1 348 SER 348 342 342 SER SER A . n 
A 1 349 VAL 349 343 343 VAL VAL A . n 
A 1 350 VAL 350 344 344 VAL VAL A . n 
A 1 351 LEU 351 345 345 LEU LEU A . n 
A 1 352 LEU 352 346 346 LEU LEU A . n 
A 1 353 LEU 353 347 347 LEU LEU A . n 
A 1 354 ARG 354 348 348 ARG ARG A . n 
A 1 355 LEU 355 349 349 LEU LEU A . n 
A 1 356 ALA 356 350 350 ALA ALA A . n 
A 1 357 LYS 357 351 351 LYS LYS A . n 
A 1 358 THR 358 352 352 THR THR A . n 
A 1 359 TYR 359 353 353 TYR TYR A . n 
A 1 360 GLU 360 354 354 GLU GLU A . n 
A 1 361 THR 361 355 355 THR THR A . n 
A 1 362 THR 362 356 356 THR THR A . n 
A 1 363 LEU 363 357 357 LEU LEU A . n 
A 1 364 GLU 364 358 358 GLU GLU A . n 
A 1 365 LYS 365 359 359 LYS LYS A . n 
A 1 366 CYS 366 360 360 CYS CYS A . n 
A 1 367 CYS 367 361 361 CYS CYS A . n 
A 1 368 ALA 368 362 362 ALA ALA A . n 
A 1 369 ALA 369 363 363 ALA ALA A . n 
A 1 370 ALA 370 364 364 ALA ALA A . n 
A 1 371 ASP 371 365 365 ASP ASP A . n 
A 1 372 PRO 372 366 366 PRO PRO A . n 
A 1 373 HIS 373 367 367 HIS HIS A . n 
A 1 374 GLU 374 368 368 GLU GLU A . n 
A 1 375 CYS 375 369 369 CYS CYS A . n 
A 1 376 TYR 376 370 370 TYR TYR A . n 
A 1 377 ALA 377 371 371 ALA ALA A . n 
A 1 378 LYS 378 372 372 LYS LYS A . n 
A 1 379 VAL 379 373 373 VAL VAL A . n 
A 1 380 PHE 380 374 374 PHE PHE A . n 
A 1 381 ASP 381 375 375 ASP ASP A . n 
A 1 382 GLU 382 376 376 GLU GLU A . n 
A 1 383 PHE 383 377 377 PHE PHE A . n 
A 1 384 LYS 384 378 378 LYS LYS A . n 
A 1 385 PRO 385 379 379 PRO PRO A . n 
A 1 386 LEU 386 380 380 LEU LEU A . n 
A 1 387 VAL 387 381 381 VAL VAL A . n 
A 1 388 GLU 388 382 382 GLU GLU A . n 
A 1 389 GLU 389 383 383 GLU GLU A . n 
A 1 390 PRO 390 384 384 PRO PRO A . n 
A 1 391 GLN 391 385 385 GLN GLN A . n 
A 1 392 ASN 392 386 386 ASN ASN A . n 
A 1 393 LEU 393 387 387 LEU LEU A . n 
A 1 394 ILE 394 388 388 ILE ILE A . n 
A 1 395 LYS 395 389 389 LYS LYS A . n 
A 1 396 GLN 396 390 390 GLN GLN A . n 
A 1 397 ASN 397 391 391 ASN ASN A . n 
A 1 398 CYS 398 392 392 CYS CYS A . n 
A 1 399 GLU 399 393 393 GLU GLU A . n 
A 1 400 LEU 400 394 394 LEU LEU A . n 
A 1 401 PHE 401 395 395 PHE PHE A . n 
A 1 402 GLU 402 396 396 GLU GLU A . n 
A 1 403 GLN 403 397 397 GLN GLN A . n 
A 1 404 LEU 404 398 398 LEU LEU A . n 
A 1 405 GLY 405 399 399 GLY GLY A . n 
A 1 406 GLU 406 400 400 GLU GLU A . n 
A 1 407 TYR 407 401 401 TYR TYR A . n 
A 1 408 LYS 408 402 402 LYS LYS A . n 
A 1 409 PHE 409 403 403 PHE PHE A . n 
A 1 410 GLN 410 404 404 GLN GLN A . n 
A 1 411 ASN 411 405 405 ASN ASN A . n 
A 1 412 ALA 412 406 406 ALA ALA A . n 
A 1 413 LEU 413 407 407 LEU LEU A . n 
A 1 414 LEU 414 408 408 LEU LEU A . n 
A 1 415 VAL 415 409 409 VAL VAL A . n 
A 1 416 ARG 416 410 410 ARG ARG A . n 
A 1 417 TYR 417 411 411 TYR TYR A . n 
A 1 418 THR 418 412 412 THR THR A . n 
A 1 419 LYS 419 413 413 LYS LYS A . n 
A 1 420 LYS 420 414 414 LYS LYS A . n 
A 1 421 VAL 421 415 415 VAL VAL A . n 
A 1 422 PRO 422 416 416 PRO PRO A . n 
A 1 423 GLN 423 417 417 GLN GLN A . n 
A 1 424 VAL 424 418 418 VAL VAL A . n 
A 1 425 SER 425 419 419 SER SER A . n 
A 1 426 THR 426 420 420 THR THR A . n 
A 1 427 PRO 427 421 421 PRO PRO A . n 
A 1 428 THR 428 422 422 THR THR A . n 
A 1 429 LEU 429 423 423 LEU LEU A . n 
A 1 430 VAL 430 424 424 VAL VAL A . n 
A 1 431 GLU 431 425 425 GLU GLU A . n 
A 1 432 VAL 432 426 426 VAL VAL A . n 
A 1 433 SER 433 427 427 SER SER A . n 
A 1 434 ARG 434 428 428 ARG ARG A . n 
A 1 435 ASN 435 429 429 ASN ASN A . n 
A 1 436 LEU 436 430 430 LEU LEU A . n 
A 1 437 GLY 437 431 431 GLY GLY A . n 
A 1 438 LYS 438 432 432 LYS LYS A . n 
A 1 439 VAL 439 433 433 VAL VAL A . n 
A 1 440 GLY 440 434 434 GLY GLY A . n 
A 1 441 SER 441 435 435 SER SER A . n 
A 1 442 LYS 442 436 436 LYS LYS A . n 
A 1 443 CYS 443 437 437 CYS CYS A . n 
A 1 444 CYS 444 438 438 CYS CYS A . n 
A 1 445 LYS 445 439 439 LYS LYS A . n 
A 1 446 HIS 446 440 440 HIS HIS A . n 
A 1 447 PRO 447 441 441 PRO PRO A . n 
A 1 448 GLU 448 442 442 GLU GLU A . n 
A 1 449 ALA 449 443 443 ALA ALA A . n 
A 1 450 LYS 450 444 444 LYS LYS A . n 
A 1 451 ARG 451 445 445 ARG ARG A . n 
A 1 452 MET 452 446 446 MET MET A . n 
A 1 453 PRO 453 447 447 PRO PRO A . n 
A 1 454 CYS 454 448 448 CYS CYS A . n 
A 1 455 ALA 455 449 449 ALA ALA A . n 
A 1 456 GLU 456 450 450 GLU GLU A . n 
A 1 457 ASP 457 451 451 ASP ASP A . n 
A 1 458 TYR 458 452 452 TYR TYR A . n 
A 1 459 LEU 459 453 453 LEU LEU A . n 
A 1 460 SER 460 454 454 SER SER A . n 
A 1 461 VAL 461 455 455 VAL VAL A . n 
A 1 462 VAL 462 456 456 VAL VAL A . n 
A 1 463 LEU 463 457 457 LEU LEU A . n 
A 1 464 ASN 464 458 458 ASN ASN A . n 
A 1 465 GLN 465 459 459 GLN GLN A . n 
A 1 466 LEU 466 460 460 LEU LEU A . n 
A 1 467 CYS 467 461 461 CYS CYS A . n 
A 1 468 VAL 468 462 462 VAL VAL A . n 
A 1 469 LEU 469 463 463 LEU LEU A . n 
A 1 470 HIS 470 464 464 HIS HIS A . n 
A 1 471 GLU 471 465 465 GLU GLU A . n 
A 1 472 LYS 472 466 466 LYS LYS A . n 
A 1 473 THR 473 467 467 THR THR A . n 
A 1 474 PRO 474 468 468 PRO PRO A . n 
A 1 475 VAL 475 469 469 VAL VAL A . n 
A 1 476 SER 476 470 470 SER SER A . n 
A 1 477 ASP 477 471 471 ASP ASP A . n 
A 1 478 ARG 478 472 472 ARG ARG A . n 
A 1 479 VAL 479 473 473 VAL VAL A . n 
A 1 480 THR 480 474 474 THR THR A . n 
A 1 481 LYS 481 475 475 LYS LYS A . n 
A 1 482 CYS 482 476 476 CYS CYS A . n 
A 1 483 CYS 483 477 477 CYS CYS A . n 
A 1 484 THR 484 478 478 THR THR A . n 
A 1 485 GLU 485 479 479 GLU GLU A . n 
A 1 486 SER 486 480 480 SER SER A . n 
A 1 487 LEU 487 481 481 LEU LEU A . n 
A 1 488 VAL 488 482 482 VAL VAL A . n 
A 1 489 ASN 489 483 483 ASN ASN A . n 
A 1 490 ARG 490 484 484 ARG ARG A . n 
A 1 491 ARG 491 485 485 ARG ARG A . n 
A 1 492 PRO 492 486 486 PRO PRO A . n 
A 1 493 CYS 493 487 487 CYS CYS A . n 
A 1 494 PHE 494 488 488 PHE PHE A . n 
A 1 495 SER 495 489 489 SER SER A . n 
A 1 496 ALA 496 490 490 ALA ALA A . n 
A 1 497 LEU 497 491 491 LEU LEU A . n 
A 1 498 GLU 498 492 492 GLU GLU A . n 
A 1 499 VAL 499 493 493 VAL VAL A . n 
A 1 500 ASP 500 494 494 ASP ASP A . n 
A 1 501 GLU 501 495 495 GLU GLU A . n 
A 1 502 THR 502 496 496 THR THR A . n 
A 1 503 TYR 503 497 497 TYR TYR A . n 
A 1 504 VAL 504 498 498 VAL VAL A . n 
A 1 505 PRO 505 499 499 PRO PRO A . n 
A 1 506 LYS 506 500 500 LYS LYS A . n 
A 1 507 GLU 507 501 501 GLU GLU A . n 
A 1 508 PHE 508 502 502 PHE PHE A . n 
A 1 509 ASN 509 503 503 ASN ASN A . n 
A 1 510 ALA 510 504 504 ALA ALA A . n 
A 1 511 GLU 511 505 505 GLU GLU A . n 
A 1 512 THR 512 506 506 THR THR A . n 
A 1 513 PHE 513 507 507 PHE PHE A . n 
A 1 514 THR 514 508 508 THR THR A . n 
A 1 515 PHE 515 509 509 PHE PHE A . n 
A 1 516 HIS 516 510 510 HIS HIS A . n 
A 1 517 ALA 517 511 511 ALA ALA A . n 
A 1 518 ASP 518 512 512 ASP ASP A . n 
A 1 519 ILE 519 513 513 ILE ILE A . n 
A 1 520 CYS 520 514 514 CYS CYS A . n 
A 1 521 THR 521 515 515 THR THR A . n 
A 1 522 LEU 522 516 516 LEU LEU A . n 
A 1 523 SER 523 517 517 SER SER A . n 
A 1 524 GLU 524 518 518 GLU GLU A . n 
A 1 525 LYS 525 519 519 LYS LYS A . n 
A 1 526 GLU 526 520 520 GLU GLU A . n 
A 1 527 ARG 527 521 521 ARG ARG A . n 
A 1 528 GLN 528 522 522 GLN GLN A . n 
A 1 529 ILE 529 523 523 ILE ILE A . n 
A 1 530 LYS 530 524 524 LYS LYS A . n 
A 1 531 LYS 531 525 525 LYS LYS A . n 
A 1 532 GLN 532 526 526 GLN GLN A . n 
A 1 533 THR 533 527 527 THR THR A . n 
A 1 534 ALA 534 528 528 ALA ALA A . n 
A 1 535 LEU 535 529 529 LEU LEU A . n 
A 1 536 VAL 536 530 530 VAL VAL A . n 
A 1 537 GLU 537 531 531 GLU GLU A . n 
A 1 538 LEU 538 532 532 LEU LEU A . n 
A 1 539 VAL 539 533 533 VAL VAL A . n 
A 1 540 LYS 540 534 534 LYS LYS A . n 
A 1 541 HIS 541 535 535 HIS HIS A . n 
A 1 542 LYS 542 536 536 LYS LYS A . n 
A 1 543 PRO 543 537 537 PRO PRO A . n 
A 1 544 LYS 544 538 538 LYS LYS A . n 
A 1 545 ALA 545 539 539 ALA ALA A . n 
A 1 546 THR 546 540 540 THR THR A . n 
A 1 547 LYS 547 541 541 LYS LYS A . n 
A 1 548 GLU 548 542 542 GLU GLU A . n 
A 1 549 GLN 549 543 543 GLN GLN A . n 
A 1 550 LEU 550 544 544 LEU LEU A . n 
A 1 551 LYS 551 545 545 LYS LYS A . n 
A 1 552 ALA 552 546 546 ALA ALA A . n 
A 1 553 VAL 553 547 547 VAL VAL A . n 
A 1 554 MET 554 548 548 MET MET A . n 
A 1 555 ASP 555 549 549 ASP ASP A . n 
A 1 556 ASP 556 550 550 ASP ASP A . n 
A 1 557 PHE 557 551 551 PHE PHE A . n 
A 1 558 ALA 558 552 552 ALA ALA A . n 
A 1 559 ALA 559 553 553 ALA ALA A . n 
A 1 560 PHE 560 554 554 PHE PHE A . n 
A 1 561 VAL 561 555 555 VAL VAL A . n 
A 1 562 GLU 562 556 556 GLU GLU A . n 
A 1 563 LYS 563 557 557 LYS LYS A . n 
A 1 564 CYS 564 558 558 CYS CYS A . n 
A 1 565 CYS 565 559 559 CYS CYS A . n 
A 1 566 LYS 566 560 560 LYS LYS A . n 
A 1 567 ALA 567 561 561 ALA ALA A . n 
A 1 568 ASP 568 562 562 ASP ASP A . n 
A 1 569 ASP 569 563 563 ASP ASP A . n 
A 1 570 LYS 570 564 564 LYS LYS A . n 
A 1 571 GLU 571 565 565 GLU GLU A . n 
A 1 572 THR 572 566 566 THR THR A . n 
A 1 573 CYS 573 567 567 CYS CYS A . n 
A 1 574 PHE 574 568 568 PHE PHE A . n 
A 1 575 ALA 575 569 569 ALA ALA A . n 
A 1 576 GLU 576 570 570 GLU GLU A . n 
A 1 577 GLU 577 571 571 GLU GLU A . n 
A 1 578 GLY 578 572 572 GLY GLY A . n 
A 1 579 LYS 579 573 573 LYS LYS A . n 
A 1 580 LYS 580 574 574 LYS LYS A . n 
A 1 581 LEU 581 575 575 LEU LEU A . n 
A 1 582 VAL 582 576 576 VAL VAL A . n 
A 1 583 ALA 583 577 577 ALA ALA A . n 
A 1 584 ALA 584 578 578 ALA ALA A . n 
A 1 585 SER 585 579 579 SER SER A . n 
A 1 586 GLN 586 580 580 GLN GLN A . n 
A 1 587 ALA 587 581 581 ALA ALA A . n 
A 1 588 ALA 588 582 582 ALA ALA A . n 
A 1 589 LEU 589 583 583 LEU LEU A . n 
A 1 590 GLY 590 584 584 GLY GLY A . n 
A 1 591 LEU 591 585 ?   ?   ?   A . n 
B 2 1   GLU 1   1   1   GLU GLU B . n 
B 2 2   VAL 2   2   2   VAL VAL B . n 
B 2 3   GLN 3   3   3   GLN GLN B . n 
B 2 4   LEU 4   4   4   LEU LEU B . n 
B 2 5   VAL 5   5   5   VAL VAL B . n 
B 2 6   GLU 6   6   6   GLU GLU B . n 
B 2 7   SER 7   7   7   SER SER B . n 
B 2 8   GLY 8   8   8   GLY GLY B . n 
B 2 9   GLY 9   9   9   GLY GLY B . n 
B 2 10  GLY 10  10  10  GLY GLY B . n 
B 2 11  LEU 11  11  11  LEU LEU B . n 
B 2 12  VAL 12  12  12  VAL VAL B . n 
B 2 13  GLN 13  13  13  GLN GLN B . n 
B 2 14  PRO 14  14  14  PRO PRO B . n 
B 2 15  GLY 15  15  15  GLY GLY B . n 
B 2 16  GLY 16  16  16  GLY GLY B . n 
B 2 17  SER 17  17  17  SER SER B . n 
B 2 18  LEU 18  18  18  LEU LEU B . n 
B 2 19  ARG 19  19  19  ARG ARG B . n 
B 2 20  LEU 20  20  20  LEU LEU B . n 
B 2 21  SER 21  21  21  SER SER B . n 
B 2 22  CYS 22  22  22  CYS CYS B . n 
B 2 23  THR 23  23  23  THR THR B . n 
B 2 24  ALA 24  24  24  ALA ALA B . n 
B 2 25  SER 25  25  25  SER SER B . n 
B 2 26  GLY 26  26  26  GLY GLY B . n 
B 2 27  TYR 27  27  27  TYR TYR B . n 
B 2 28  MET 28  28  28  MET MET B . n 
B 2 29  SER 29  29  29  SER SER B . n 
B 2 30  SER 30  30  30  SER SER B . n 
B 2 31  THR 31  31  31  THR THR B . n 
B 2 32  TYR 32  32  32  TYR TYR B . n 
B 2 33  TYR 33  33  33  TYR TYR B . n 
B 2 34  MET 34  34  34  MET MET B . n 
B 2 35  ALA 35  35  35  ALA ALA B . n 
B 2 36  TRP 36  36  36  TRP TRP B . n 
B 2 37  PHE 37  37  37  PHE PHE B . n 
B 2 38  ARG 38  38  38  ARG ARG B . n 
B 2 39  GLN 39  39  39  GLN GLN B . n 
B 2 40  PRO 40  40  40  PRO PRO B . n 
B 2 41  PRO 41  41  41  PRO PRO B . n 
B 2 42  GLY 42  42  42  GLY GLY B . n 
B 2 43  LYS 43  43  43  LYS LYS B . n 
B 2 44  GLY 44  44  44  GLY GLY B . n 
B 2 45  LEU 45  45  45  LEU LEU B . n 
B 2 46  GLU 46  46  46  GLU GLU B . n 
B 2 47  GLY 47  47  47  GLY GLY B . n 
B 2 48  VAL 48  48  48  VAL VAL B . n 
B 2 49  ALA 49  49  49  ALA ALA B . n 
B 2 50  LEU 50  50  50  LEU LEU B . n 
B 2 51  ILE 51  51  51  ILE ILE B . n 
B 2 52  SER 52  52  52  SER SER B . n 
B 2 53  PRO 53  53  53  PRO PRO B . n 
B 2 54  TYR 54  54  54  TYR TYR B . n 
B 2 55  GLY 55  55  55  GLY GLY B . n 
B 2 56  GLY 56  56  56  GLY GLY B . n 
B 2 57  ALA 57  57  57  ALA ALA B . n 
B 2 58  THR 58  58  58  THR THR B . n 
B 2 59  ASN 59  59  59  ASN ASN B . n 
B 2 60  TYR 60  60  60  TYR TYR B . n 
B 2 61  ALA 61  61  61  ALA ALA B . n 
B 2 62  ASP 62  62  62  ASP ASP B . n 
B 2 63  SER 63  63  63  SER SER B . n 
B 2 64  VAL 64  64  64  VAL VAL B . n 
B 2 65  LYS 65  65  65  LYS LYS B . n 
B 2 66  GLY 66  66  66  GLY GLY B . n 
B 2 67  ARG 67  67  67  ARG ARG B . n 
B 2 68  PHE 68  68  68  PHE PHE B . n 
B 2 69  THR 69  69  69  THR THR B . n 
B 2 70  ILE 70  70  70  ILE ILE B . n 
B 2 71  SER 71  71  71  SER SER B . n 
B 2 72  ARG 72  72  72  ARG ARG B . n 
B 2 73  ASP 73  73  73  ASP ASP B . n 
B 2 74  ASN 74  74  74  ASN ASN B . n 
B 2 75  ALA 75  75  75  ALA ALA B . n 
B 2 76  LYS 76  76  76  LYS LYS B . n 
B 2 77  ASN 77  77  77  ASN ASN B . n 
B 2 78  THR 78  78  78  THR THR B . n 
B 2 79  LEU 79  79  79  LEU LEU B . n 
B 2 80  TYR 80  80  80  TYR TYR B . n 
B 2 81  LEU 81  81  81  LEU LEU B . n 
B 2 82  GLN 82  82  82  GLN GLN B . n 
B 2 83  MET 83  83  83  MET MET B . n 
B 2 84  ASN 84  84  84  ASN ASN B . n 
B 2 85  SER 85  85  85  SER SER B . n 
B 2 86  LEU 86  86  86  LEU LEU B . n 
B 2 87  LYS 87  87  87  LYS LYS B . n 
B 2 88  PRO 88  88  88  PRO PRO B . n 
B 2 89  GLU 89  89  89  GLU GLU B . n 
B 2 90  ASP 90  90  90  ASP ASP B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ALA 92  92  92  ALA ALA B . n 
B 2 93  ARG 93  93  93  ARG ARG B . n 
B 2 94  TYR 94  94  94  TYR TYR B . n 
B 2 95  TYR 95  95  95  TYR TYR B . n 
B 2 96  CYS 96  96  96  CYS CYS B . n 
B 2 97  ALA 97  97  97  ALA ALA B . n 
B 2 98  ALA 98  98  98  ALA ALA B . n 
B 2 99  GLY 99  99  99  GLY GLY B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 THR 101 101 101 THR THR B . n 
B 2 102 LEU 102 102 102 LEU LEU B . n 
B 2 103 THR 103 103 103 THR THR B . n 
B 2 104 MET 104 104 104 MET MET B . n 
B 2 105 VAL 105 105 105 VAL VAL B . n 
B 2 106 VAL 106 106 106 VAL VAL B . n 
B 2 107 ALA 107 107 107 ALA ALA B . n 
B 2 108 ASN 108 108 108 ASN ASN B . n 
B 2 109 TYR 109 109 109 TYR TYR B . n 
B 2 110 ARG 110 110 110 ARG ARG B . n 
B 2 111 TYR 111 111 111 TYR TYR B . n 
B 2 112 TRP 112 112 112 TRP TRP B . n 
B 2 113 GLY 113 113 113 GLY GLY B . n 
B 2 114 GLN 114 114 114 GLN GLN B . n 
B 2 115 GLY 115 115 115 GLY GLY B . n 
B 2 116 THR 116 116 116 THR THR B . n 
B 2 117 LEU 117 117 117 LEU LEU B . n 
B 2 118 VAL 118 118 118 VAL VAL B . n 
B 2 119 THR 119 119 119 THR THR B . n 
B 2 120 VAL 120 120 120 VAL VAL B . n 
B 2 121 SER 121 121 121 SER SER B . n 
B 2 122 SER 122 122 122 SER SER B . n 
C 1 1   ARG 1   -5  ?   ?   ?   C . n 
C 1 2   GLY 2   -4  ?   ?   ?   C . n 
C 1 3   VAL 3   -3  ?   ?   ?   C . n 
C 1 4   PHE 4   -2  ?   ?   ?   C . n 
C 1 5   ARG 5   -1  ?   ?   ?   C . n 
C 1 6   ARG 6   0   ?   ?   ?   C . n 
C 1 7   ASP 7   1   ?   ?   ?   C . n 
C 1 8   ALA 8   2   ?   ?   ?   C . n 
C 1 9   HIS 9   3   3   HIS HIS C . n 
C 1 10  LYS 10  4   4   LYS LYS C . n 
C 1 11  SER 11  5   5   SER SER C . n 
C 1 12  GLU 12  6   6   GLU GLU C . n 
C 1 13  VAL 13  7   7   VAL VAL C . n 
C 1 14  ALA 14  8   8   ALA ALA C . n 
C 1 15  HIS 15  9   9   HIS HIS C . n 
C 1 16  ARG 16  10  10  ARG ARG C . n 
C 1 17  PHE 17  11  11  PHE PHE C . n 
C 1 18  LYS 18  12  12  LYS LYS C . n 
C 1 19  ASP 19  13  13  ASP ASP C . n 
C 1 20  LEU 20  14  14  LEU LEU C . n 
C 1 21  GLY 21  15  15  GLY GLY C . n 
C 1 22  GLU 22  16  16  GLU GLU C . n 
C 1 23  GLU 23  17  17  GLU GLU C . n 
C 1 24  ASN 24  18  18  ASN ASN C . n 
C 1 25  PHE 25  19  19  PHE PHE C . n 
C 1 26  LYS 26  20  20  LYS LYS C . n 
C 1 27  ALA 27  21  21  ALA ALA C . n 
C 1 28  LEU 28  22  22  LEU LEU C . n 
C 1 29  VAL 29  23  23  VAL VAL C . n 
C 1 30  LEU 30  24  24  LEU LEU C . n 
C 1 31  ILE 31  25  25  ILE ILE C . n 
C 1 32  ALA 32  26  26  ALA ALA C . n 
C 1 33  PHE 33  27  27  PHE PHE C . n 
C 1 34  ALA 34  28  28  ALA ALA C . n 
C 1 35  GLN 35  29  29  GLN GLN C . n 
C 1 36  TYR 36  30  30  TYR TYR C . n 
C 1 37  LEU 37  31  31  LEU LEU C . n 
C 1 38  GLN 38  32  32  GLN GLN C . n 
C 1 39  GLN 39  33  33  GLN GLN C . n 
C 1 40  CYS 40  34  34  CYS CYS C . n 
C 1 41  PRO 41  35  35  PRO PRO C . n 
C 1 42  PHE 42  36  36  PHE PHE C . n 
C 1 43  GLU 43  37  37  GLU GLU C . n 
C 1 44  ASP 44  38  38  ASP ASP C . n 
C 1 45  HIS 45  39  39  HIS HIS C . n 
C 1 46  VAL 46  40  40  VAL VAL C . n 
C 1 47  LYS 47  41  41  LYS LYS C . n 
C 1 48  LEU 48  42  42  LEU LEU C . n 
C 1 49  VAL 49  43  43  VAL VAL C . n 
C 1 50  ASN 50  44  44  ASN ASN C . n 
C 1 51  GLU 51  45  45  GLU GLU C . n 
C 1 52  VAL 52  46  46  VAL VAL C . n 
C 1 53  THR 53  47  47  THR THR C . n 
C 1 54  GLU 54  48  48  GLU GLU C . n 
C 1 55  PHE 55  49  49  PHE PHE C . n 
C 1 56  ALA 56  50  50  ALA ALA C . n 
C 1 57  LYS 57  51  51  LYS LYS C . n 
C 1 58  THR 58  52  52  THR THR C . n 
C 1 59  CYS 59  53  53  CYS CYS C . n 
C 1 60  VAL 60  54  54  VAL VAL C . n 
C 1 61  ALA 61  55  55  ALA ALA C . n 
C 1 62  ASP 62  56  56  ASP ASP C . n 
C 1 63  GLU 63  57  57  GLU GLU C . n 
C 1 64  SER 64  58  58  SER SER C . n 
C 1 65  ALA 65  59  59  ALA ALA C . n 
C 1 66  GLU 66  60  60  GLU GLU C . n 
C 1 67  ASN 67  61  61  ASN ASN C . n 
C 1 68  CYS 68  62  62  CYS CYS C . n 
C 1 69  ASP 69  63  63  ASP ASP C . n 
C 1 70  LYS 70  64  64  LYS LYS C . n 
C 1 71  SER 71  65  65  SER SER C . n 
C 1 72  LEU 72  66  66  LEU LEU C . n 
C 1 73  HIS 73  67  67  HIS HIS C . n 
C 1 74  THR 74  68  68  THR THR C . n 
C 1 75  LEU 75  69  69  LEU LEU C . n 
C 1 76  PHE 76  70  70  PHE PHE C . n 
C 1 77  GLY 77  71  71  GLY GLY C . n 
C 1 78  ASP 78  72  72  ASP ASP C . n 
C 1 79  LYS 79  73  73  LYS LYS C . n 
C 1 80  LEU 80  74  74  LEU LEU C . n 
C 1 81  CYS 81  75  75  CYS CYS C . n 
C 1 82  THR 82  76  76  THR THR C . n 
C 1 83  VAL 83  77  77  VAL VAL C . n 
C 1 84  ALA 84  78  78  ALA ALA C . n 
C 1 85  THR 85  79  79  THR THR C . n 
C 1 86  LEU 86  80  80  LEU LEU C . n 
C 1 87  ARG 87  81  ?   ?   ?   C . n 
C 1 88  GLU 88  82  ?   ?   ?   C . n 
C 1 89  THR 89  83  ?   ?   ?   C . n 
C 1 90  TYR 90  84  ?   ?   ?   C . n 
C 1 91  GLY 91  85  ?   ?   ?   C . n 
C 1 92  GLU 92  86  ?   ?   ?   C . n 
C 1 93  MET 93  87  ?   ?   ?   C . n 
C 1 94  ALA 94  88  88  ALA ALA C . n 
C 1 95  ASP 95  89  89  ASP ASP C . n 
C 1 96  CYS 96  90  90  CYS CYS C . n 
C 1 97  CYS 97  91  91  CYS CYS C . n 
C 1 98  ALA 98  92  92  ALA ALA C . n 
C 1 99  LYS 99  93  93  LYS LYS C . n 
C 1 100 GLN 100 94  94  GLN GLN C . n 
C 1 101 GLU 101 95  95  GLU GLU C . n 
C 1 102 PRO 102 96  96  PRO PRO C . n 
C 1 103 GLU 103 97  97  GLU GLU C . n 
C 1 104 ARG 104 98  ?   ?   ?   C . n 
C 1 105 ASN 105 99  99  ASN ASN C . n 
C 1 106 GLU 106 100 100 GLU GLU C . n 
C 1 107 CYS 107 101 101 CYS CYS C . n 
C 1 108 PHE 108 102 102 PHE PHE C . n 
C 1 109 LEU 109 103 103 LEU LEU C . n 
C 1 110 GLN 110 104 104 GLN GLN C . n 
C 1 111 HIS 111 105 105 HIS HIS C . n 
C 1 112 LYS 112 106 106 LYS LYS C . n 
C 1 113 ASP 113 107 107 ASP ASP C . n 
C 1 114 ASP 114 108 108 ASP ASP C . n 
C 1 115 ASN 115 109 109 ASN ASN C . n 
C 1 116 PRO 116 110 110 PRO PRO C . n 
C 1 117 ASN 117 111 111 ASN ASN C . n 
C 1 118 LEU 118 112 112 LEU LEU C . n 
C 1 119 PRO 119 113 113 PRO PRO C . n 
C 1 120 ARG 120 114 114 ARG ARG C . n 
C 1 121 LEU 121 115 115 LEU LEU C . n 
C 1 122 VAL 122 116 116 VAL VAL C . n 
C 1 123 ARG 123 117 117 ARG ARG C . n 
C 1 124 PRO 124 118 118 PRO PRO C . n 
C 1 125 GLU 125 119 119 GLU GLU C . n 
C 1 126 VAL 126 120 120 VAL VAL C . n 
C 1 127 ASP 127 121 121 ASP ASP C . n 
C 1 128 VAL 128 122 122 VAL VAL C . n 
C 1 129 MET 129 123 123 MET MET C . n 
C 1 130 CYS 130 124 124 CYS CYS C . n 
C 1 131 THR 131 125 125 THR THR C . n 
C 1 132 ALA 132 126 126 ALA ALA C . n 
C 1 133 PHE 133 127 127 PHE PHE C . n 
C 1 134 HIS 134 128 128 HIS HIS C . n 
C 1 135 ASP 135 129 129 ASP ASP C . n 
C 1 136 ASN 136 130 130 ASN ASN C . n 
C 1 137 GLU 137 131 131 GLU GLU C . n 
C 1 138 GLU 138 132 132 GLU GLU C . n 
C 1 139 THR 139 133 133 THR THR C . n 
C 1 140 PHE 140 134 134 PHE PHE C . n 
C 1 141 LEU 141 135 135 LEU LEU C . n 
C 1 142 LYS 142 136 136 LYS LYS C . n 
C 1 143 LYS 143 137 137 LYS LYS C . n 
C 1 144 TYR 144 138 138 TYR TYR C . n 
C 1 145 LEU 145 139 139 LEU LEU C . n 
C 1 146 TYR 146 140 140 TYR TYR C . n 
C 1 147 GLU 147 141 141 GLU GLU C . n 
C 1 148 ILE 148 142 142 ILE ILE C . n 
C 1 149 ALA 149 143 143 ALA ALA C . n 
C 1 150 ARG 150 144 144 ARG ARG C . n 
C 1 151 ARG 151 145 145 ARG ARG C . n 
C 1 152 HIS 152 146 146 HIS HIS C . n 
C 1 153 PRO 153 147 147 PRO PRO C . n 
C 1 154 TYR 154 148 148 TYR TYR C . n 
C 1 155 PHE 155 149 149 PHE PHE C . n 
C 1 156 TYR 156 150 150 TYR TYR C . n 
C 1 157 ALA 157 151 151 ALA ALA C . n 
C 1 158 PRO 158 152 152 PRO PRO C . n 
C 1 159 GLU 159 153 153 GLU GLU C . n 
C 1 160 LEU 160 154 154 LEU LEU C . n 
C 1 161 LEU 161 155 155 LEU LEU C . n 
C 1 162 PHE 162 156 156 PHE PHE C . n 
C 1 163 PHE 163 157 157 PHE PHE C . n 
C 1 164 ALA 164 158 158 ALA ALA C . n 
C 1 165 LYS 165 159 159 LYS LYS C . n 
C 1 166 ARG 166 160 160 ARG ARG C . n 
C 1 167 TYR 167 161 161 TYR TYR C . n 
C 1 168 LYS 168 162 162 LYS LYS C . n 
C 1 169 ALA 169 163 163 ALA ALA C . n 
C 1 170 ALA 170 164 164 ALA ALA C . n 
C 1 171 PHE 171 165 165 PHE PHE C . n 
C 1 172 THR 172 166 166 THR THR C . n 
C 1 173 GLU 173 167 167 GLU GLU C . n 
C 1 174 CYS 174 168 168 CYS CYS C . n 
C 1 175 CYS 175 169 169 CYS CYS C . n 
C 1 176 GLN 176 170 ?   ?   ?   C . n 
C 1 177 ALA 177 171 ?   ?   ?   C . n 
C 1 178 ALA 178 172 ?   ?   ?   C . n 
C 1 179 ASP 179 173 173 ASP ASP C . n 
C 1 180 LYS 180 174 174 LYS LYS C . n 
C 1 181 ALA 181 175 175 ALA ALA C . n 
C 1 182 ALA 182 176 176 ALA ALA C . n 
C 1 183 CYS 183 177 177 CYS CYS C . n 
C 1 184 LEU 184 178 178 LEU LEU C . n 
C 1 185 LEU 185 179 179 LEU LEU C . n 
C 1 186 PRO 186 180 180 PRO PRO C . n 
C 1 187 LYS 187 181 181 LYS LYS C . n 
C 1 188 LEU 188 182 182 LEU LEU C . n 
C 1 189 ASP 189 183 183 ASP ASP C . n 
C 1 190 GLU 190 184 184 GLU GLU C . n 
C 1 191 LEU 191 185 185 LEU LEU C . n 
C 1 192 ARG 192 186 186 ARG ARG C . n 
C 1 193 ASP 193 187 187 ASP ASP C . n 
C 1 194 GLU 194 188 188 GLU GLU C . n 
C 1 195 GLY 195 189 189 GLY GLY C . n 
C 1 196 LYS 196 190 190 LYS LYS C . n 
C 1 197 ALA 197 191 191 ALA ALA C . n 
C 1 198 SER 198 192 192 SER SER C . n 
C 1 199 SER 199 193 193 SER SER C . n 
C 1 200 ALA 200 194 194 ALA ALA C . n 
C 1 201 LYS 201 195 195 LYS LYS C . n 
C 1 202 GLN 202 196 196 GLN GLN C . n 
C 1 203 ARG 203 197 197 ARG ARG C . n 
C 1 204 LEU 204 198 198 LEU LEU C . n 
C 1 205 LYS 205 199 199 LYS LYS C . n 
C 1 206 CYS 206 200 200 CYS CYS C . n 
C 1 207 ALA 207 201 201 ALA ALA C . n 
C 1 208 SER 208 202 202 SER SER C . n 
C 1 209 LEU 209 203 203 LEU LEU C . n 
C 1 210 GLN 210 204 204 GLN GLN C . n 
C 1 211 LYS 211 205 205 LYS LYS C . n 
C 1 212 PHE 212 206 206 PHE PHE C . n 
C 1 213 GLY 213 207 207 GLY GLY C . n 
C 1 214 GLU 214 208 208 GLU GLU C . n 
C 1 215 ARG 215 209 209 ARG ARG C . n 
C 1 216 ALA 216 210 210 ALA ALA C . n 
C 1 217 PHE 217 211 211 PHE PHE C . n 
C 1 218 LYS 218 212 212 LYS LYS C . n 
C 1 219 ALA 219 213 213 ALA ALA C . n 
C 1 220 TRP 220 214 214 TRP TRP C . n 
C 1 221 ALA 221 215 215 ALA ALA C . n 
C 1 222 VAL 222 216 216 VAL VAL C . n 
C 1 223 ALA 223 217 217 ALA ALA C . n 
C 1 224 ARG 224 218 218 ARG ARG C . n 
C 1 225 LEU 225 219 219 LEU LEU C . n 
C 1 226 SER 226 220 220 SER SER C . n 
C 1 227 GLN 227 221 221 GLN GLN C . n 
C 1 228 ARG 228 222 222 ARG ARG C . n 
C 1 229 PHE 229 223 223 PHE PHE C . n 
C 1 230 PRO 230 224 224 PRO PRO C . n 
C 1 231 LYS 231 225 225 LYS LYS C . n 
C 1 232 ALA 232 226 226 ALA ALA C . n 
C 1 233 GLU 233 227 227 GLU GLU C . n 
C 1 234 PHE 234 228 228 PHE PHE C . n 
C 1 235 ALA 235 229 229 ALA ALA C . n 
C 1 236 GLU 236 230 230 GLU GLU C . n 
C 1 237 VAL 237 231 231 VAL VAL C . n 
C 1 238 SER 238 232 232 SER SER C . n 
C 1 239 LYS 239 233 233 LYS LYS C . n 
C 1 240 LEU 240 234 234 LEU LEU C . n 
C 1 241 VAL 241 235 235 VAL VAL C . n 
C 1 242 THR 242 236 236 THR THR C . n 
C 1 243 ASP 243 237 237 ASP ASP C . n 
C 1 244 LEU 244 238 238 LEU LEU C . n 
C 1 245 THR 245 239 239 THR THR C . n 
C 1 246 LYS 246 240 240 LYS LYS C . n 
C 1 247 VAL 247 241 241 VAL VAL C . n 
C 1 248 HIS 248 242 242 HIS HIS C . n 
C 1 249 THR 249 243 243 THR THR C . n 
C 1 250 GLU 250 244 244 GLU GLU C . n 
C 1 251 CYS 251 245 245 CYS CYS C . n 
C 1 252 CYS 252 246 246 CYS CYS C . n 
C 1 253 HIS 253 247 247 HIS HIS C . n 
C 1 254 GLY 254 248 248 GLY GLY C . n 
C 1 255 ASP 255 249 249 ASP ASP C . n 
C 1 256 LEU 256 250 250 LEU LEU C . n 
C 1 257 LEU 257 251 251 LEU LEU C . n 
C 1 258 GLU 258 252 252 GLU GLU C . n 
C 1 259 CYS 259 253 253 CYS CYS C . n 
C 1 260 ALA 260 254 254 ALA ALA C . n 
C 1 261 ASP 261 255 255 ASP ASP C . n 
C 1 262 ASP 262 256 256 ASP ASP C . n 
C 1 263 ARG 263 257 257 ARG ARG C . n 
C 1 264 ALA 264 258 258 ALA ALA C . n 
C 1 265 ASP 265 259 259 ASP ASP C . n 
C 1 266 LEU 266 260 260 LEU LEU C . n 
C 1 267 ALA 267 261 261 ALA ALA C . n 
C 1 268 LYS 268 262 262 LYS LYS C . n 
C 1 269 TYR 269 263 263 TYR TYR C . n 
C 1 270 ILE 270 264 264 ILE ILE C . n 
C 1 271 CYS 271 265 265 CYS CYS C . n 
C 1 272 GLU 272 266 266 GLU GLU C . n 
C 1 273 ASN 273 267 267 ASN ASN C . n 
C 1 274 GLN 274 268 268 GLN GLN C . n 
C 1 275 ASP 275 269 269 ASP ASP C . n 
C 1 276 SER 276 270 270 SER SER C . n 
C 1 277 ILE 277 271 271 ILE ILE C . n 
C 1 278 SER 278 272 272 SER SER C . n 
C 1 279 SER 279 273 273 SER SER C . n 
C 1 280 LYS 280 274 274 LYS LYS C . n 
C 1 281 LEU 281 275 275 LEU LEU C . n 
C 1 282 LYS 282 276 276 LYS LYS C . n 
C 1 283 GLU 283 277 277 GLU GLU C . n 
C 1 284 CYS 284 278 278 CYS CYS C . n 
C 1 285 CYS 285 279 279 CYS CYS C . n 
C 1 286 GLU 286 280 280 GLU GLU C . n 
C 1 287 LYS 287 281 281 LYS LYS C . n 
C 1 288 PRO 288 282 282 PRO PRO C . n 
C 1 289 LEU 289 283 283 LEU LEU C . n 
C 1 290 LEU 290 284 284 LEU LEU C . n 
C 1 291 GLU 291 285 285 GLU GLU C . n 
C 1 292 LYS 292 286 286 LYS LYS C . n 
C 1 293 SER 293 287 287 SER SER C . n 
C 1 294 HIS 294 288 288 HIS HIS C . n 
C 1 295 CYS 295 289 289 CYS CYS C . n 
C 1 296 ILE 296 290 290 ILE ILE C . n 
C 1 297 ALA 297 291 291 ALA ALA C . n 
C 1 298 GLU 298 292 292 GLU GLU C . n 
C 1 299 VAL 299 293 293 VAL VAL C . n 
C 1 300 GLU 300 294 294 GLU GLU C . n 
C 1 301 ASN 301 295 295 ASN ASN C . n 
C 1 302 ASP 302 296 296 ASP ASP C . n 
C 1 303 GLU 303 297 297 GLU GLU C . n 
C 1 304 MET 304 298 298 MET MET C . n 
C 1 305 PRO 305 299 299 PRO PRO C . n 
C 1 306 ALA 306 300 300 ALA ALA C . n 
C 1 307 ASP 307 301 301 ASP ASP C . n 
C 1 308 LEU 308 302 302 LEU LEU C . n 
C 1 309 PRO 309 303 303 PRO PRO C . n 
C 1 310 SER 310 304 304 SER SER C . n 
C 1 311 LEU 311 305 305 LEU LEU C . n 
C 1 312 ALA 312 306 306 ALA ALA C . n 
C 1 313 ALA 313 307 307 ALA ALA C . n 
C 1 314 ASP 314 308 308 ASP ASP C . n 
C 1 315 PHE 315 309 309 PHE PHE C . n 
C 1 316 VAL 316 310 310 VAL VAL C . n 
C 1 317 GLU 317 311 311 GLU GLU C . n 
C 1 318 SER 318 312 312 SER SER C . n 
C 1 319 LYS 319 313 313 LYS LYS C . n 
C 1 320 ASP 320 314 314 ASP ASP C . n 
C 1 321 VAL 321 315 315 VAL VAL C . n 
C 1 322 CYS 322 316 316 CYS CYS C . n 
C 1 323 LYS 323 317 317 LYS LYS C . n 
C 1 324 ASN 324 318 318 ASN ASN C . n 
C 1 325 TYR 325 319 319 TYR TYR C . n 
C 1 326 ALA 326 320 320 ALA ALA C . n 
C 1 327 GLU 327 321 321 GLU GLU C . n 
C 1 328 ALA 328 322 322 ALA ALA C . n 
C 1 329 LYS 329 323 323 LYS LYS C . n 
C 1 330 ASP 330 324 324 ASP ASP C . n 
C 1 331 VAL 331 325 325 VAL VAL C . n 
C 1 332 PHE 332 326 326 PHE PHE C . n 
C 1 333 LEU 333 327 327 LEU LEU C . n 
C 1 334 GLY 334 328 328 GLY GLY C . n 
C 1 335 MET 335 329 329 MET MET C . n 
C 1 336 PHE 336 330 330 PHE PHE C . n 
C 1 337 LEU 337 331 331 LEU LEU C . n 
C 1 338 TYR 338 332 332 TYR TYR C . n 
C 1 339 GLU 339 333 333 GLU GLU C . n 
C 1 340 TYR 340 334 334 TYR TYR C . n 
C 1 341 ALA 341 335 335 ALA ALA C . n 
C 1 342 ARG 342 336 336 ARG ARG C . n 
C 1 343 ARG 343 337 337 ARG ARG C . n 
C 1 344 HIS 344 338 338 HIS HIS C . n 
C 1 345 PRO 345 339 339 PRO PRO C . n 
C 1 346 ASP 346 340 340 ASP ASP C . n 
C 1 347 TYR 347 341 341 TYR TYR C . n 
C 1 348 SER 348 342 342 SER SER C . n 
C 1 349 VAL 349 343 343 VAL VAL C . n 
C 1 350 VAL 350 344 344 VAL VAL C . n 
C 1 351 LEU 351 345 345 LEU LEU C . n 
C 1 352 LEU 352 346 346 LEU LEU C . n 
C 1 353 LEU 353 347 347 LEU LEU C . n 
C 1 354 ARG 354 348 348 ARG ARG C . n 
C 1 355 LEU 355 349 349 LEU LEU C . n 
C 1 356 ALA 356 350 350 ALA ALA C . n 
C 1 357 LYS 357 351 351 LYS LYS C . n 
C 1 358 THR 358 352 352 THR THR C . n 
C 1 359 TYR 359 353 353 TYR TYR C . n 
C 1 360 GLU 360 354 354 GLU GLU C . n 
C 1 361 THR 361 355 355 THR THR C . n 
C 1 362 THR 362 356 356 THR THR C . n 
C 1 363 LEU 363 357 357 LEU LEU C . n 
C 1 364 GLU 364 358 358 GLU GLU C . n 
C 1 365 LYS 365 359 359 LYS LYS C . n 
C 1 366 CYS 366 360 360 CYS CYS C . n 
C 1 367 CYS 367 361 361 CYS CYS C . n 
C 1 368 ALA 368 362 362 ALA ALA C . n 
C 1 369 ALA 369 363 363 ALA ALA C . n 
C 1 370 ALA 370 364 364 ALA ALA C . n 
C 1 371 ASP 371 365 365 ASP ASP C . n 
C 1 372 PRO 372 366 366 PRO PRO C . n 
C 1 373 HIS 373 367 367 HIS HIS C . n 
C 1 374 GLU 374 368 368 GLU GLU C . n 
C 1 375 CYS 375 369 369 CYS CYS C . n 
C 1 376 TYR 376 370 370 TYR TYR C . n 
C 1 377 ALA 377 371 371 ALA ALA C . n 
C 1 378 LYS 378 372 372 LYS LYS C . n 
C 1 379 VAL 379 373 373 VAL VAL C . n 
C 1 380 PHE 380 374 374 PHE PHE C . n 
C 1 381 ASP 381 375 375 ASP ASP C . n 
C 1 382 GLU 382 376 376 GLU GLU C . n 
C 1 383 PHE 383 377 377 PHE PHE C . n 
C 1 384 LYS 384 378 378 LYS LYS C . n 
C 1 385 PRO 385 379 379 PRO PRO C . n 
C 1 386 LEU 386 380 380 LEU LEU C . n 
C 1 387 VAL 387 381 381 VAL VAL C . n 
C 1 388 GLU 388 382 382 GLU GLU C . n 
C 1 389 GLU 389 383 383 GLU GLU C . n 
C 1 390 PRO 390 384 384 PRO PRO C . n 
C 1 391 GLN 391 385 385 GLN GLN C . n 
C 1 392 ASN 392 386 386 ASN ASN C . n 
C 1 393 LEU 393 387 387 LEU LEU C . n 
C 1 394 ILE 394 388 388 ILE ILE C . n 
C 1 395 LYS 395 389 389 LYS LYS C . n 
C 1 396 GLN 396 390 390 GLN GLN C . n 
C 1 397 ASN 397 391 391 ASN ASN C . n 
C 1 398 CYS 398 392 392 CYS CYS C . n 
C 1 399 GLU 399 393 393 GLU GLU C . n 
C 1 400 LEU 400 394 394 LEU LEU C . n 
C 1 401 PHE 401 395 395 PHE PHE C . n 
C 1 402 GLU 402 396 396 GLU GLU C . n 
C 1 403 GLN 403 397 397 GLN GLN C . n 
C 1 404 LEU 404 398 398 LEU LEU C . n 
C 1 405 GLY 405 399 399 GLY GLY C . n 
C 1 406 GLU 406 400 400 GLU GLU C . n 
C 1 407 TYR 407 401 401 TYR TYR C . n 
C 1 408 LYS 408 402 402 LYS LYS C . n 
C 1 409 PHE 409 403 403 PHE PHE C . n 
C 1 410 GLN 410 404 404 GLN GLN C . n 
C 1 411 ASN 411 405 405 ASN ASN C . n 
C 1 412 ALA 412 406 406 ALA ALA C . n 
C 1 413 LEU 413 407 407 LEU LEU C . n 
C 1 414 LEU 414 408 408 LEU LEU C . n 
C 1 415 VAL 415 409 409 VAL VAL C . n 
C 1 416 ARG 416 410 410 ARG ARG C . n 
C 1 417 TYR 417 411 411 TYR TYR C . n 
C 1 418 THR 418 412 412 THR THR C . n 
C 1 419 LYS 419 413 413 LYS LYS C . n 
C 1 420 LYS 420 414 414 LYS LYS C . n 
C 1 421 VAL 421 415 415 VAL VAL C . n 
C 1 422 PRO 422 416 416 PRO PRO C . n 
C 1 423 GLN 423 417 417 GLN GLN C . n 
C 1 424 VAL 424 418 418 VAL VAL C . n 
C 1 425 SER 425 419 419 SER SER C . n 
C 1 426 THR 426 420 420 THR THR C . n 
C 1 427 PRO 427 421 421 PRO PRO C . n 
C 1 428 THR 428 422 422 THR THR C . n 
C 1 429 LEU 429 423 423 LEU LEU C . n 
C 1 430 VAL 430 424 424 VAL VAL C . n 
C 1 431 GLU 431 425 425 GLU GLU C . n 
C 1 432 VAL 432 426 426 VAL VAL C . n 
C 1 433 SER 433 427 427 SER SER C . n 
C 1 434 ARG 434 428 428 ARG ARG C . n 
C 1 435 ASN 435 429 429 ASN ASN C . n 
C 1 436 LEU 436 430 430 LEU LEU C . n 
C 1 437 GLY 437 431 431 GLY GLY C . n 
C 1 438 LYS 438 432 432 LYS LYS C . n 
C 1 439 VAL 439 433 433 VAL VAL C . n 
C 1 440 GLY 440 434 434 GLY GLY C . n 
C 1 441 SER 441 435 435 SER SER C . n 
C 1 442 LYS 442 436 436 LYS LYS C . n 
C 1 443 CYS 443 437 437 CYS CYS C . n 
C 1 444 CYS 444 438 438 CYS CYS C . n 
C 1 445 LYS 445 439 439 LYS LYS C . n 
C 1 446 HIS 446 440 440 HIS HIS C . n 
C 1 447 PRO 447 441 441 PRO PRO C . n 
C 1 448 GLU 448 442 442 GLU GLU C . n 
C 1 449 ALA 449 443 443 ALA ALA C . n 
C 1 450 LYS 450 444 444 LYS LYS C . n 
C 1 451 ARG 451 445 445 ARG ARG C . n 
C 1 452 MET 452 446 446 MET MET C . n 
C 1 453 PRO 453 447 447 PRO PRO C . n 
C 1 454 CYS 454 448 448 CYS CYS C . n 
C 1 455 ALA 455 449 449 ALA ALA C . n 
C 1 456 GLU 456 450 450 GLU GLU C . n 
C 1 457 ASP 457 451 451 ASP ASP C . n 
C 1 458 TYR 458 452 452 TYR TYR C . n 
C 1 459 LEU 459 453 453 LEU LEU C . n 
C 1 460 SER 460 454 454 SER SER C . n 
C 1 461 VAL 461 455 455 VAL VAL C . n 
C 1 462 VAL 462 456 456 VAL VAL C . n 
C 1 463 LEU 463 457 457 LEU LEU C . n 
C 1 464 ASN 464 458 458 ASN ASN C . n 
C 1 465 GLN 465 459 459 GLN GLN C . n 
C 1 466 LEU 466 460 460 LEU LEU C . n 
C 1 467 CYS 467 461 461 CYS CYS C . n 
C 1 468 VAL 468 462 462 VAL VAL C . n 
C 1 469 LEU 469 463 463 LEU LEU C . n 
C 1 470 HIS 470 464 464 HIS HIS C . n 
C 1 471 GLU 471 465 465 GLU GLU C . n 
C 1 472 LYS 472 466 466 LYS LYS C . n 
C 1 473 THR 473 467 467 THR THR C . n 
C 1 474 PRO 474 468 468 PRO PRO C . n 
C 1 475 VAL 475 469 469 VAL VAL C . n 
C 1 476 SER 476 470 470 SER SER C . n 
C 1 477 ASP 477 471 471 ASP ASP C . n 
C 1 478 ARG 478 472 472 ARG ARG C . n 
C 1 479 VAL 479 473 473 VAL VAL C . n 
C 1 480 THR 480 474 474 THR THR C . n 
C 1 481 LYS 481 475 475 LYS LYS C . n 
C 1 482 CYS 482 476 476 CYS CYS C . n 
C 1 483 CYS 483 477 477 CYS CYS C . n 
C 1 484 THR 484 478 478 THR THR C . n 
C 1 485 GLU 485 479 479 GLU GLU C . n 
C 1 486 SER 486 480 480 SER SER C . n 
C 1 487 LEU 487 481 481 LEU LEU C . n 
C 1 488 VAL 488 482 482 VAL VAL C . n 
C 1 489 ASN 489 483 483 ASN ASN C . n 
C 1 490 ARG 490 484 484 ARG ARG C . n 
C 1 491 ARG 491 485 485 ARG ARG C . n 
C 1 492 PRO 492 486 486 PRO PRO C . n 
C 1 493 CYS 493 487 487 CYS CYS C . n 
C 1 494 PHE 494 488 488 PHE PHE C . n 
C 1 495 SER 495 489 489 SER SER C . n 
C 1 496 ALA 496 490 490 ALA ALA C . n 
C 1 497 LEU 497 491 491 LEU LEU C . n 
C 1 498 GLU 498 492 492 GLU GLU C . n 
C 1 499 VAL 499 493 493 VAL VAL C . n 
C 1 500 ASP 500 494 494 ASP ASP C . n 
C 1 501 GLU 501 495 495 GLU GLU C . n 
C 1 502 THR 502 496 496 THR THR C . n 
C 1 503 TYR 503 497 497 TYR TYR C . n 
C 1 504 VAL 504 498 498 VAL VAL C . n 
C 1 505 PRO 505 499 499 PRO PRO C . n 
C 1 506 LYS 506 500 500 LYS LYS C . n 
C 1 507 GLU 507 501 501 GLU GLU C . n 
C 1 508 PHE 508 502 502 PHE PHE C . n 
C 1 509 ASN 509 503 503 ASN ASN C . n 
C 1 510 ALA 510 504 504 ALA ALA C . n 
C 1 511 GLU 511 505 505 GLU GLU C . n 
C 1 512 THR 512 506 506 THR THR C . n 
C 1 513 PHE 513 507 507 PHE PHE C . n 
C 1 514 THR 514 508 508 THR THR C . n 
C 1 515 PHE 515 509 509 PHE PHE C . n 
C 1 516 HIS 516 510 510 HIS HIS C . n 
C 1 517 ALA 517 511 511 ALA ALA C . n 
C 1 518 ASP 518 512 512 ASP ASP C . n 
C 1 519 ILE 519 513 513 ILE ILE C . n 
C 1 520 CYS 520 514 514 CYS CYS C . n 
C 1 521 THR 521 515 515 THR THR C . n 
C 1 522 LEU 522 516 516 LEU LEU C . n 
C 1 523 SER 523 517 517 SER SER C . n 
C 1 524 GLU 524 518 518 GLU GLU C . n 
C 1 525 LYS 525 519 519 LYS LYS C . n 
C 1 526 GLU 526 520 520 GLU GLU C . n 
C 1 527 ARG 527 521 521 ARG ARG C . n 
C 1 528 GLN 528 522 522 GLN GLN C . n 
C 1 529 ILE 529 523 523 ILE ILE C . n 
C 1 530 LYS 530 524 524 LYS LYS C . n 
C 1 531 LYS 531 525 525 LYS LYS C . n 
C 1 532 GLN 532 526 526 GLN GLN C . n 
C 1 533 THR 533 527 527 THR THR C . n 
C 1 534 ALA 534 528 528 ALA ALA C . n 
C 1 535 LEU 535 529 529 LEU LEU C . n 
C 1 536 VAL 536 530 530 VAL VAL C . n 
C 1 537 GLU 537 531 531 GLU GLU C . n 
C 1 538 LEU 538 532 532 LEU LEU C . n 
C 1 539 VAL 539 533 533 VAL VAL C . n 
C 1 540 LYS 540 534 534 LYS LYS C . n 
C 1 541 HIS 541 535 535 HIS HIS C . n 
C 1 542 LYS 542 536 536 LYS LYS C . n 
C 1 543 PRO 543 537 537 PRO PRO C . n 
C 1 544 LYS 544 538 538 LYS LYS C . n 
C 1 545 ALA 545 539 539 ALA ALA C . n 
C 1 546 THR 546 540 540 THR THR C . n 
C 1 547 LYS 547 541 541 LYS LYS C . n 
C 1 548 GLU 548 542 542 GLU GLU C . n 
C 1 549 GLN 549 543 543 GLN GLN C . n 
C 1 550 LEU 550 544 544 LEU LEU C . n 
C 1 551 LYS 551 545 545 LYS LYS C . n 
C 1 552 ALA 552 546 546 ALA ALA C . n 
C 1 553 VAL 553 547 547 VAL VAL C . n 
C 1 554 MET 554 548 548 MET MET C . n 
C 1 555 ASP 555 549 549 ASP ASP C . n 
C 1 556 ASP 556 550 550 ASP ASP C . n 
C 1 557 PHE 557 551 551 PHE PHE C . n 
C 1 558 ALA 558 552 552 ALA ALA C . n 
C 1 559 ALA 559 553 553 ALA ALA C . n 
C 1 560 PHE 560 554 554 PHE PHE C . n 
C 1 561 VAL 561 555 555 VAL VAL C . n 
C 1 562 GLU 562 556 556 GLU GLU C . n 
C 1 563 LYS 563 557 557 LYS LYS C . n 
C 1 564 CYS 564 558 558 CYS CYS C . n 
C 1 565 CYS 565 559 559 CYS CYS C . n 
C 1 566 LYS 566 560 560 LYS LYS C . n 
C 1 567 ALA 567 561 561 ALA ALA C . n 
C 1 568 ASP 568 562 562 ASP ASP C . n 
C 1 569 ASP 569 563 563 ASP ASP C . n 
C 1 570 LYS 570 564 564 LYS LYS C . n 
C 1 571 GLU 571 565 565 GLU GLU C . n 
C 1 572 THR 572 566 566 THR THR C . n 
C 1 573 CYS 573 567 567 CYS CYS C . n 
C 1 574 PHE 574 568 568 PHE PHE C . n 
C 1 575 ALA 575 569 569 ALA ALA C . n 
C 1 576 GLU 576 570 570 GLU GLU C . n 
C 1 577 GLU 577 571 571 GLU GLU C . n 
C 1 578 GLY 578 572 572 GLY GLY C . n 
C 1 579 LYS 579 573 573 LYS LYS C . n 
C 1 580 LYS 580 574 574 LYS LYS C . n 
C 1 581 LEU 581 575 575 LEU LEU C . n 
C 1 582 VAL 582 576 576 VAL VAL C . n 
C 1 583 ALA 583 577 577 ALA ALA C . n 
C 1 584 ALA 584 578 578 ALA ALA C . n 
C 1 585 SER 585 579 579 SER SER C . n 
C 1 586 GLN 586 580 580 GLN GLN C . n 
C 1 587 ALA 587 581 581 ALA ALA C . n 
C 1 588 ALA 588 582 582 ALA ALA C . n 
C 1 589 LEU 589 583 583 LEU LEU C . n 
C 1 590 GLY 590 584 584 GLY GLY C . n 
C 1 591 LEU 591 585 ?   ?   ?   C . n 
D 2 1   GLU 1   1   1   GLU GLU D . n 
D 2 2   VAL 2   2   2   VAL VAL D . n 
D 2 3   GLN 3   3   3   GLN GLN D . n 
D 2 4   LEU 4   4   4   LEU LEU D . n 
D 2 5   VAL 5   5   5   VAL VAL D . n 
D 2 6   GLU 6   6   6   GLU GLU D . n 
D 2 7   SER 7   7   7   SER SER D . n 
D 2 8   GLY 8   8   8   GLY GLY D . n 
D 2 9   GLY 9   9   9   GLY GLY D . n 
D 2 10  GLY 10  10  10  GLY GLY D . n 
D 2 11  LEU 11  11  11  LEU LEU D . n 
D 2 12  VAL 12  12  12  VAL VAL D . n 
D 2 13  GLN 13  13  13  GLN GLN D . n 
D 2 14  PRO 14  14  14  PRO PRO D . n 
D 2 15  GLY 15  15  15  GLY GLY D . n 
D 2 16  GLY 16  16  16  GLY GLY D . n 
D 2 17  SER 17  17  17  SER SER D . n 
D 2 18  LEU 18  18  18  LEU LEU D . n 
D 2 19  ARG 19  19  19  ARG ARG D . n 
D 2 20  LEU 20  20  20  LEU LEU D . n 
D 2 21  SER 21  21  21  SER SER D . n 
D 2 22  CYS 22  22  22  CYS CYS D . n 
D 2 23  THR 23  23  23  THR THR D . n 
D 2 24  ALA 24  24  24  ALA ALA D . n 
D 2 25  SER 25  25  25  SER SER D . n 
D 2 26  GLY 26  26  26  GLY GLY D . n 
D 2 27  TYR 27  27  27  TYR TYR D . n 
D 2 28  MET 28  28  28  MET MET D . n 
D 2 29  SER 29  29  29  SER SER D . n 
D 2 30  SER 30  30  30  SER SER D . n 
D 2 31  THR 31  31  31  THR THR D . n 
D 2 32  TYR 32  32  32  TYR TYR D . n 
D 2 33  TYR 33  33  33  TYR TYR D . n 
D 2 34  MET 34  34  34  MET MET D . n 
D 2 35  ALA 35  35  35  ALA ALA D . n 
D 2 36  TRP 36  36  36  TRP TRP D . n 
D 2 37  PHE 37  37  37  PHE PHE D . n 
D 2 38  ARG 38  38  38  ARG ARG D . n 
D 2 39  GLN 39  39  39  GLN GLN D . n 
D 2 40  PRO 40  40  40  PRO PRO D . n 
D 2 41  PRO 41  41  41  PRO PRO D . n 
D 2 42  GLY 42  42  42  GLY GLY D . n 
D 2 43  LYS 43  43  43  LYS LYS D . n 
D 2 44  GLY 44  44  44  GLY GLY D . n 
D 2 45  LEU 45  45  45  LEU LEU D . n 
D 2 46  GLU 46  46  46  GLU GLU D . n 
D 2 47  GLY 47  47  47  GLY GLY D . n 
D 2 48  VAL 48  48  48  VAL VAL D . n 
D 2 49  ALA 49  49  49  ALA ALA D . n 
D 2 50  LEU 50  50  50  LEU LEU D . n 
D 2 51  ILE 51  51  51  ILE ILE D . n 
D 2 52  SER 52  52  52  SER SER D . n 
D 2 53  PRO 53  53  53  PRO PRO D . n 
D 2 54  TYR 54  54  54  TYR TYR D . n 
D 2 55  GLY 55  55  55  GLY GLY D . n 
D 2 56  GLY 56  56  56  GLY GLY D . n 
D 2 57  ALA 57  57  57  ALA ALA D . n 
D 2 58  THR 58  58  58  THR THR D . n 
D 2 59  ASN 59  59  59  ASN ASN D . n 
D 2 60  TYR 60  60  60  TYR TYR D . n 
D 2 61  ALA 61  61  61  ALA ALA D . n 
D 2 62  ASP 62  62  62  ASP ASP D . n 
D 2 63  SER 63  63  63  SER SER D . n 
D 2 64  VAL 64  64  64  VAL VAL D . n 
D 2 65  LYS 65  65  65  LYS LYS D . n 
D 2 66  GLY 66  66  66  GLY GLY D . n 
D 2 67  ARG 67  67  67  ARG ARG D . n 
D 2 68  PHE 68  68  68  PHE PHE D . n 
D 2 69  THR 69  69  69  THR THR D . n 
D 2 70  ILE 70  70  70  ILE ILE D . n 
D 2 71  SER 71  71  71  SER SER D . n 
D 2 72  ARG 72  72  72  ARG ARG D . n 
D 2 73  ASP 73  73  73  ASP ASP D . n 
D 2 74  ASN 74  74  74  ASN ASN D . n 
D 2 75  ALA 75  75  75  ALA ALA D . n 
D 2 76  LYS 76  76  76  LYS LYS D . n 
D 2 77  ASN 77  77  77  ASN ASN D . n 
D 2 78  THR 78  78  78  THR THR D . n 
D 2 79  LEU 79  79  79  LEU LEU D . n 
D 2 80  TYR 80  80  80  TYR TYR D . n 
D 2 81  LEU 81  81  81  LEU LEU D . n 
D 2 82  GLN 82  82  82  GLN GLN D . n 
D 2 83  MET 83  83  83  MET MET D . n 
D 2 84  ASN 84  84  84  ASN ASN D . n 
D 2 85  SER 85  85  85  SER SER D . n 
D 2 86  LEU 86  86  86  LEU LEU D . n 
D 2 87  LYS 87  87  87  LYS LYS D . n 
D 2 88  PRO 88  88  88  PRO PRO D . n 
D 2 89  GLU 89  89  89  GLU GLU D . n 
D 2 90  ASP 90  90  90  ASP ASP D . n 
D 2 91  THR 91  91  91  THR THR D . n 
D 2 92  ALA 92  92  92  ALA ALA D . n 
D 2 93  ARG 93  93  93  ARG ARG D . n 
D 2 94  TYR 94  94  94  TYR TYR D . n 
D 2 95  TYR 95  95  95  TYR TYR D . n 
D 2 96  CYS 96  96  96  CYS CYS D . n 
D 2 97  ALA 97  97  97  ALA ALA D . n 
D 2 98  ALA 98  98  98  ALA ALA D . n 
D 2 99  GLY 99  99  99  GLY GLY D . n 
D 2 100 SER 100 100 100 SER SER D . n 
D 2 101 THR 101 101 101 THR THR D . n 
D 2 102 LEU 102 102 102 LEU LEU D . n 
D 2 103 THR 103 103 103 THR THR D . n 
D 2 104 MET 104 104 104 MET MET D . n 
D 2 105 VAL 105 105 105 VAL VAL D . n 
D 2 106 VAL 106 106 106 VAL VAL D . n 
D 2 107 ALA 107 107 107 ALA ALA D . n 
D 2 108 ASN 108 108 108 ASN ASN D . n 
D 2 109 TYR 109 109 109 TYR TYR D . n 
D 2 110 ARG 110 110 110 ARG ARG D . n 
D 2 111 TYR 111 111 111 TYR TYR D . n 
D 2 112 TRP 112 112 112 TRP TRP D . n 
D 2 113 GLY 113 113 113 GLY GLY D . n 
D 2 114 GLN 114 114 114 GLN GLN D . n 
D 2 115 GLY 115 115 115 GLY GLY D . n 
D 2 116 THR 116 116 116 THR THR D . n 
D 2 117 LEU 117 117 117 LEU LEU D . n 
D 2 118 VAL 118 118 118 VAL VAL D . n 
D 2 119 THR 119 119 119 THR THR D . n 
D 2 120 VAL 120 120 120 VAL VAL D . n 
D 2 121 SER 121 121 121 SER SER D . n 
D 2 122 SER 122 122 122 SER SER D . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0425 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? 0.7.7    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? 0.7.7    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? 2.8.3    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.23 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Y9S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     65.260 
_cell.length_a_esd                 ? 
_cell.length_b                     143.900 
_cell.length_b_esd                 ? 
_cell.length_c                     93.670 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Y9S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Y9S 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.69 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.26 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.15 M DL-Malic acid pH 7.0, 20% w/v Polyethylene glycol 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-01-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8Y9S 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.88 
_reflns.d_resolution_low                               46.25 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38264 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.05 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.310 
_reflns.pdbx_Rpim_I_all                                0.120 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.983 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.286 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.88 
_reflns_shell.d_res_low                                     2.95 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           19122 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2819 
_reflns_shell.percent_possible_obs                          99.4 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.8 
_reflns_shell.pdbx_chi_squared                              1.04 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.1 
_reflns_shell.pdbx_Rrim_I_all                               2.183 
_reflns_shell.pdbx_Rpim_I_all                               0.825 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.436 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.018 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            6.60 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            2.23 
_refine.aniso_B[2][2]                            -5.73 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -1.57 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               72.932 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.934 
_refine.correlation_coeff_Fo_to_Fc_free          0.893 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Y9S 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.88 
_refine.ls_d_res_low                             46.25 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     36434 
_refine.ls_number_reflns_R_free                  1808 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.27 
_refine.ls_percent_reflns_R_free                 4.7 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.23313 
_refine.ls_R_factor_R_free                       0.29265 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.23008 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.474 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             30.159 
_refine.overall_SU_ML                            0.511 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.88 
_refine_hist.d_res_low                        46.25 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               10903 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        10903 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005  0.012  11342 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  10688 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.545  1.865  15310 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.556  1.777  24774 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.844  5.000  1406  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 8.568  5.000  60    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 17.284 10.000 2046  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.157  0.200  1690  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.005  0.020  13170 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  2490  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 6.228  7.092  5636  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 6.227  7.092  5636  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 9.976  12.740 7038  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 9.976  12.740 7039  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.234  7.592  5706  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 6.233  7.592  5707  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 10.099 13.763 8273  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 15.588 68.46  13165 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 15.589 68.46  13166 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.880 
_refine_ls_shell.d_res_low                        2.955 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             133 
_refine_ls_shell.number_reflns_R_work             2675 
_refine_ls_shell.percent_reflns_obs               99.26 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.387 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.419 
# 
_struct.entry_id                     8Y9S 
_struct.title                        'Crystal structure of nanobody MY6321 bound to human serum albumin (HSA)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Y9S 
_struct_keywords.text            'antibody, human serum albumin, PROTEIN BINDING' 
_struct_keywords.pdbx_keywords   'PROTEIN BINDING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ALBU_HUMAN P02768 ? 1 
;RGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKL
CTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPEL
LFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKL
VTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKD
VCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCEL
FEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVT
KCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAF
VEKCCKADDKETCFAEEGKKLVAASQAALGL
;
19 
2 PDB 8Y9S       8Y9S   ? 2 ? 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8Y9S A 1 ? 591 ? P02768 19 ? 609 ? -5 585 
2 2 8Y9S B 1 ? 122 ? 8Y9S   1  ? 122 ? 1  122 
3 1 8Y9S C 1 ? 591 ? P02768 19 ? 609 ? -5 585 
4 2 8Y9S D 1 ? 122 ? 8Y9S   1  ? 122 ? 1  122 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1780  ? 
1 MORE         -8    ? 
1 'SSA (A^2)'  33430 ? 
2 'ABSA (A^2)' 1790  ? 
2 MORE         -8    ? 
2 'SSA (A^2)'  33370 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B 
2 1 C,D 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'gel filtration'                   ? 
2 1 'isothermal titration calorimetry' ? 
3 1 'surface plasmon resonance'        ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 11  ? GLY A 21  ? SER A 5   GLY A 15  1 ? 11 
HELX_P HELX_P2  AA2 GLY A 21  ? LEU A 37  ? GLY A 15  LEU A 31  1 ? 17 
HELX_P HELX_P3  AA3 PRO A 41  ? ASP A 62  ? PRO A 35  ASP A 56  1 ? 22 
HELX_P HELX_P4  AA4 SER A 71  ? THR A 82  ? SER A 65  THR A 76  1 ? 12 
HELX_P HELX_P5  AA5 ALA A 94  ? LYS A 99  ? ALA A 88  LYS A 93  1 ? 6  
HELX_P HELX_P6  AA6 GLU A 125 ? ASN A 136 ? GLU A 119 ASN A 130 1 ? 12 
HELX_P HELX_P7  AA7 GLU A 137 ? HIS A 152 ? GLU A 131 HIS A 146 1 ? 16 
HELX_P HELX_P8  AA8 TYR A 156 ? CYS A 175 ? TYR A 150 CYS A 169 1 ? 20 
HELX_P HELX_P9  AA9 PRO A 186 ? PHE A 229 ? PRO A 180 PHE A 223 1 ? 44 
HELX_P HELX_P10 AB1 GLU A 233 ? GLY A 254 ? GLU A 227 GLY A 248 1 ? 22 
HELX_P HELX_P11 AB2 LEU A 256 ? ASN A 273 ? LEU A 250 ASN A 267 1 ? 18 
HELX_P HELX_P12 AB3 GLN A 274 ? ILE A 277 ? GLN A 268 ILE A 271 5 ? 4  
HELX_P HELX_P13 AB4 GLU A 283 ? LYS A 287 ? GLU A 277 LYS A 281 5 ? 5  
HELX_P HELX_P14 AB5 PRO A 288 ? VAL A 299 ? PRO A 282 VAL A 293 1 ? 12 
HELX_P HELX_P15 AB6 LEU A 311 ? VAL A 316 ? LEU A 305 VAL A 310 1 ? 6  
HELX_P HELX_P16 AB7 ASP A 320 ? ALA A 328 ? ASP A 314 ALA A 322 1 ? 9  
HELX_P HELX_P17 AB8 ALA A 328 ? HIS A 344 ? ALA A 322 HIS A 338 1 ? 17 
HELX_P HELX_P18 AB9 SER A 348 ? ALA A 368 ? SER A 342 ALA A 362 1 ? 21 
HELX_P HELX_P19 AC1 ASP A 371 ? LYS A 378 ? ASP A 365 LYS A 372 1 ? 8  
HELX_P HELX_P20 AC2 VAL A 379 ? VAL A 421 ? VAL A 373 VAL A 415 1 ? 43 
HELX_P HELX_P21 AC3 SER A 425 ? CYS A 444 ? SER A 419 CYS A 438 1 ? 20 
HELX_P HELX_P22 AC4 PRO A 447 ? ALA A 449 ? PRO A 441 ALA A 443 5 ? 3  
HELX_P HELX_P23 AC5 LYS A 450 ? THR A 473 ? LYS A 444 THR A 467 1 ? 24 
HELX_P HELX_P24 AC6 SER A 476 ? THR A 484 ? SER A 470 THR A 478 1 ? 9  
HELX_P HELX_P25 AC7 ASN A 489 ? LEU A 497 ? ASN A 483 LEU A 491 1 ? 9  
HELX_P HELX_P26 AC8 ALA A 510 ? THR A 514 ? ALA A 504 THR A 508 5 ? 5  
HELX_P HELX_P27 AC9 ALA A 517 ? LEU A 522 ? ALA A 511 LEU A 516 1 ? 6  
HELX_P HELX_P28 AD1 SER A 523 ? LYS A 542 ? SER A 517 LYS A 536 1 ? 20 
HELX_P HELX_P29 AD2 GLU A 548 ? ALA A 567 ? GLU A 542 ALA A 561 1 ? 20 
HELX_P HELX_P30 AD3 ASP A 569 ? ALA A 588 ? ASP A 563 ALA A 582 1 ? 20 
HELX_P HELX_P31 AD4 ASP B 62  ? LYS B 65  ? ASP B 62  LYS B 65  5 ? 4  
HELX_P HELX_P32 AD5 LYS B 87  ? THR B 91  ? LYS B 87  THR B 91  5 ? 5  
HELX_P HELX_P33 AD6 VAL B 105 ? ALA B 107 ? VAL B 105 ALA B 107 5 ? 3  
HELX_P HELX_P34 AD7 SER C 11  ? LEU C 37  ? SER C 5   LEU C 31  1 ? 27 
HELX_P HELX_P35 AD8 PRO C 41  ? ASP C 62  ? PRO C 35  ASP C 56  1 ? 22 
HELX_P HELX_P36 AD9 SER C 71  ? ALA C 84  ? SER C 65  ALA C 78  1 ? 14 
HELX_P HELX_P37 AE1 ASP C 95  ? LYS C 99  ? ASP C 89  LYS C 93  1 ? 5  
HELX_P HELX_P38 AE2 GLU C 106 ? HIS C 111 ? GLU C 100 HIS C 105 1 ? 6  
HELX_P HELX_P39 AE3 GLU C 125 ? ASN C 136 ? GLU C 119 ASN C 130 1 ? 12 
HELX_P HELX_P40 AE4 GLU C 137 ? HIS C 152 ? GLU C 131 HIS C 146 1 ? 16 
HELX_P HELX_P41 AE5 TYR C 156 ? CYS C 175 ? TYR C 150 CYS C 169 1 ? 20 
HELX_P HELX_P42 AE6 CYS C 183 ? GLY C 213 ? CYS C 177 GLY C 207 1 ? 31 
HELX_P HELX_P43 AE7 GLY C 213 ? PHE C 229 ? GLY C 207 PHE C 223 1 ? 17 
HELX_P HELX_P44 AE8 GLU C 233 ? GLY C 254 ? GLU C 227 GLY C 248 1 ? 22 
HELX_P HELX_P45 AE9 LEU C 256 ? ASN C 273 ? LEU C 250 ASN C 267 1 ? 18 
HELX_P HELX_P46 AF1 GLN C 274 ? ILE C 277 ? GLN C 268 ILE C 271 5 ? 4  
HELX_P HELX_P47 AF2 GLU C 283 ? LYS C 287 ? GLU C 277 LYS C 281 5 ? 5  
HELX_P HELX_P48 AF3 PRO C 288 ? GLU C 298 ? PRO C 282 GLU C 292 1 ? 11 
HELX_P HELX_P49 AF4 LEU C 311 ? VAL C 316 ? LEU C 305 VAL C 310 1 ? 6  
HELX_P HELX_P50 AF5 ASP C 320 ? ALA C 328 ? ASP C 314 ALA C 322 1 ? 9  
HELX_P HELX_P51 AF6 ALA C 328 ? HIS C 344 ? ALA C 322 HIS C 338 1 ? 17 
HELX_P HELX_P52 AF7 SER C 348 ? CYS C 367 ? SER C 342 CYS C 361 1 ? 20 
HELX_P HELX_P53 AF8 ASP C 371 ? LYS C 378 ? ASP C 365 LYS C 372 1 ? 8  
HELX_P HELX_P54 AF9 VAL C 379 ? VAL C 421 ? VAL C 373 VAL C 415 1 ? 43 
HELX_P HELX_P55 AG1 SER C 425 ? LYS C 445 ? SER C 419 LYS C 439 1 ? 21 
HELX_P HELX_P56 AG2 PRO C 447 ? THR C 473 ? PRO C 441 THR C 467 1 ? 27 
HELX_P HELX_P57 AG3 SER C 476 ? GLU C 485 ? SER C 470 GLU C 479 1 ? 10 
HELX_P HELX_P58 AG4 SER C 486 ? VAL C 488 ? SER C 480 VAL C 482 5 ? 3  
HELX_P HELX_P59 AG5 ASN C 489 ? ALA C 496 ? ASN C 483 ALA C 490 1 ? 8  
HELX_P HELX_P60 AG6 ASN C 509 ? THR C 514 ? ASN C 503 THR C 508 1 ? 6  
HELX_P HELX_P61 AG7 ALA C 517 ? LEU C 522 ? ALA C 511 LEU C 516 1 ? 6  
HELX_P HELX_P62 AG8 SER C 523 ? LYS C 542 ? SER C 517 LYS C 536 1 ? 20 
HELX_P HELX_P63 AG9 GLU C 548 ? ALA C 567 ? GLU C 542 ALA C 561 1 ? 20 
HELX_P HELX_P64 AH1 ASP C 569 ? ALA C 588 ? ASP C 563 ALA C 582 1 ? 20 
HELX_P HELX_P65 AH2 MET D 28  ? TYR D 32  ? MET D 28  TYR D 32  5 ? 5  
HELX_P HELX_P66 AH3 ASP D 62  ? LYS D 65  ? ASP D 62  LYS D 65  5 ? 4  
HELX_P HELX_P67 AH4 LYS D 87  ? THR D 91  ? LYS D 87  THR D 91  5 ? 5  
HELX_P HELX_P68 AH5 VAL D 105 ? ALA D 107 ? VAL D 105 ALA D 107 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 59  SG ? ? ? 1_555 A CYS 68  SG ? ? A CYS 53  A CYS 62  1_555 ? ? ? ? ? ? ? 2.064 ? ? 
disulf2  disulf ? ? A CYS 81  SG ? ? ? 1_555 A CYS 97  SG ? ? A CYS 75  A CYS 91  1_555 ? ? ? ? ? ? ? 2.044 ? ? 
disulf3  disulf ? ? A CYS 96  SG ? ? ? 1_555 A CYS 107 SG ? ? A CYS 90  A CYS 101 1_555 ? ? ? ? ? ? ? 2.024 ? ? 
disulf4  disulf ? ? A CYS 130 SG ? ? ? 1_555 A CYS 175 SG ? ? A CYS 124 A CYS 169 1_555 ? ? ? ? ? ? ? 2.058 ? ? 
disulf5  disulf ? ? A CYS 174 SG ? ? ? 1_555 A CYS 183 SG ? ? A CYS 168 A CYS 177 1_555 ? ? ? ? ? ? ? 2.041 ? ? 
disulf6  disulf ? ? A CYS 206 SG ? ? ? 1_555 A CYS 252 SG ? ? A CYS 200 A CYS 246 1_555 ? ? ? ? ? ? ? 2.013 ? ? 
disulf7  disulf ? ? A CYS 251 SG ? ? ? 1_555 A CYS 259 SG ? ? A CYS 245 A CYS 253 1_555 ? ? ? ? ? ? ? 1.998 ? ? 
disulf8  disulf ? ? A CYS 271 SG ? ? ? 1_555 A CYS 285 SG ? ? A CYS 265 A CYS 279 1_555 ? ? ? ? ? ? ? 2.861 ? ? 
disulf9  disulf ? ? A CYS 322 SG ? ? ? 1_555 A CYS 367 SG ? ? A CYS 316 A CYS 361 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf10 disulf ? ? A CYS 366 SG ? ? ? 1_555 A CYS 375 SG ? ? A CYS 360 A CYS 369 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
disulf11 disulf ? ? A CYS 398 SG ? ? ? 1_555 A CYS 444 SG ? ? A CYS 392 A CYS 438 1_555 ? ? ? ? ? ? ? 2.280 ? ? 
disulf12 disulf ? ? A CYS 443 SG ? ? ? 1_555 A CYS 454 SG ? ? A CYS 437 A CYS 448 1_555 ? ? ? ? ? ? ? 2.880 ? ? 
disulf13 disulf ? ? A CYS 467 SG ? ? ? 1_555 A CYS 483 SG ? ? A CYS 461 A CYS 477 1_555 ? ? ? ? ? ? ? 2.047 ? ? 
disulf14 disulf ? ? A CYS 520 SG ? ? ? 1_555 A CYS 565 SG ? ? A CYS 514 A CYS 559 1_555 ? ? ? ? ? ? ? 2.060 ? ? 
disulf15 disulf ? ? A CYS 564 SG ? ? ? 1_555 A CYS 573 SG ? ? A CYS 558 A CYS 567 1_555 ? ? ? ? ? ? ? 2.939 ? ? 
disulf16 disulf ? ? B CYS 22  SG ? ? ? 1_555 B CYS 96  SG ? ? B CYS 22  B CYS 96  1_555 ? ? ? ? ? ? ? 2.710 ? ? 
disulf17 disulf ? ? C CYS 59  SG ? ? ? 1_555 C CYS 68  SG ? ? C CYS 53  C CYS 62  1_555 ? ? ? ? ? ? ? 2.070 ? ? 
disulf18 disulf ? ? C CYS 81  SG ? ? ? 1_555 C CYS 97  SG ? ? C CYS 75  C CYS 91  1_555 ? ? ? ? ? ? ? 2.051 ? ? 
disulf19 disulf ? ? C CYS 130 SG ? ? ? 1_555 C CYS 175 SG ? ? C CYS 124 C CYS 169 1_555 ? ? ? ? ? ? ? 2.075 ? ? 
disulf20 disulf ? ? C CYS 174 SG ? ? ? 1_555 C CYS 183 SG ? ? C CYS 168 C CYS 177 1_555 ? ? ? ? ? ? ? 2.018 ? ? 
disulf21 disulf ? ? C CYS 206 SG ? ? ? 1_555 C CYS 252 SG ? ? C CYS 200 C CYS 246 1_555 ? ? ? ? ? ? ? 2.014 ? ? 
disulf22 disulf ? ? C CYS 251 SG ? ? ? 1_555 C CYS 259 SG ? ? C CYS 245 C CYS 253 1_555 ? ? ? ? ? ? ? 2.012 ? ? 
disulf23 disulf ? ? C CYS 271 SG ? ? ? 1_555 C CYS 285 SG ? ? C CYS 265 C CYS 279 1_555 ? ? ? ? ? ? ? 2.660 ? ? 
disulf24 disulf ? ? C CYS 322 SG ? ? ? 1_555 C CYS 367 SG ? ? C CYS 316 C CYS 361 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf25 disulf ? ? C CYS 366 SG ? ? ? 1_555 C CYS 375 SG ? ? C CYS 360 C CYS 369 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
disulf26 disulf ? ? C CYS 398 SG ? ? ? 1_555 C CYS 444 SG ? ? C CYS 392 C CYS 438 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf27 disulf ? ? C CYS 443 SG ? ? ? 1_555 C CYS 454 SG ? ? C CYS 437 C CYS 448 1_555 ? ? ? ? ? ? ? 2.054 ? ? 
disulf28 disulf ? ? C CYS 467 SG ? ? ? 1_555 C CYS 483 SG ? ? C CYS 461 C CYS 477 1_555 ? ? ? ? ? ? ? 2.034 ? ? 
disulf29 disulf ? ? C CYS 520 SG ? ? ? 1_555 C CYS 565 SG ? ? C CYS 514 C CYS 559 1_555 ? ? ? ? ? ? ? 2.065 ? ? 
disulf30 disulf ? ? D CYS 22  SG ? ? ? 1_555 D CYS 96  SG ? ? D CYS 22  D CYS 96  1_555 ? ? ? ? ? ? ? 2.609 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  CYS A 59  ? CYS A 68  ? CYS A 53  ? 1_555 CYS A 62  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2  CYS A 81  ? CYS A 97  ? CYS A 75  ? 1_555 CYS A 91  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3  CYS A 96  ? CYS A 107 ? CYS A 90  ? 1_555 CYS A 101 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4  CYS A 130 ? CYS A 175 ? CYS A 124 ? 1_555 CYS A 169 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5  CYS A 174 ? CYS A 183 ? CYS A 168 ? 1_555 CYS A 177 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6  CYS A 206 ? CYS A 252 ? CYS A 200 ? 1_555 CYS A 246 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7  CYS A 251 ? CYS A 259 ? CYS A 245 ? 1_555 CYS A 253 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8  CYS A 271 ? CYS A 285 ? CYS A 265 ? 1_555 CYS A 279 ? 1_555 SG SG . . . None 'Disulfide bridge' 
9  CYS A 322 ? CYS A 367 ? CYS A 316 ? 1_555 CYS A 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 
10 CYS A 366 ? CYS A 375 ? CYS A 360 ? 1_555 CYS A 369 ? 1_555 SG SG . . . None 'Disulfide bridge' 
11 CYS A 398 ? CYS A 444 ? CYS A 392 ? 1_555 CYS A 438 ? 1_555 SG SG . . . None 'Disulfide bridge' 
12 CYS A 443 ? CYS A 454 ? CYS A 437 ? 1_555 CYS A 448 ? 1_555 SG SG . . . None 'Disulfide bridge' 
13 CYS A 467 ? CYS A 483 ? CYS A 461 ? 1_555 CYS A 477 ? 1_555 SG SG . . . None 'Disulfide bridge' 
14 CYS A 520 ? CYS A 565 ? CYS A 514 ? 1_555 CYS A 559 ? 1_555 SG SG . . . None 'Disulfide bridge' 
15 CYS A 564 ? CYS A 573 ? CYS A 558 ? 1_555 CYS A 567 ? 1_555 SG SG . . . None 'Disulfide bridge' 
16 CYS B 22  ? CYS B 96  ? CYS B 22  ? 1_555 CYS B 96  ? 1_555 SG SG . . . None 'Disulfide bridge' 
17 CYS C 59  ? CYS C 68  ? CYS C 53  ? 1_555 CYS C 62  ? 1_555 SG SG . . . None 'Disulfide bridge' 
18 CYS C 81  ? CYS C 97  ? CYS C 75  ? 1_555 CYS C 91  ? 1_555 SG SG . . . None 'Disulfide bridge' 
19 CYS C 130 ? CYS C 175 ? CYS C 124 ? 1_555 CYS C 169 ? 1_555 SG SG . . . None 'Disulfide bridge' 
20 CYS C 174 ? CYS C 183 ? CYS C 168 ? 1_555 CYS C 177 ? 1_555 SG SG . . . None 'Disulfide bridge' 
21 CYS C 206 ? CYS C 252 ? CYS C 200 ? 1_555 CYS C 246 ? 1_555 SG SG . . . None 'Disulfide bridge' 
22 CYS C 251 ? CYS C 259 ? CYS C 245 ? 1_555 CYS C 253 ? 1_555 SG SG . . . None 'Disulfide bridge' 
23 CYS C 271 ? CYS C 285 ? CYS C 265 ? 1_555 CYS C 279 ? 1_555 SG SG . . . None 'Disulfide bridge' 
24 CYS C 322 ? CYS C 367 ? CYS C 316 ? 1_555 CYS C 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 
25 CYS C 366 ? CYS C 375 ? CYS C 360 ? 1_555 CYS C 369 ? 1_555 SG SG . . . None 'Disulfide bridge' 
26 CYS C 398 ? CYS C 444 ? CYS C 392 ? 1_555 CYS C 438 ? 1_555 SG SG . . . None 'Disulfide bridge' 
27 CYS C 443 ? CYS C 454 ? CYS C 437 ? 1_555 CYS C 448 ? 1_555 SG SG . . . None 'Disulfide bridge' 
28 CYS C 467 ? CYS C 483 ? CYS C 461 ? 1_555 CYS C 477 ? 1_555 SG SG . . . None 'Disulfide bridge' 
29 CYS C 520 ? CYS C 565 ? CYS C 514 ? 1_555 CYS C 559 ? 1_555 SG SG . . . None 'Disulfide bridge' 
30 CYS D 22  ? CYS D 96  ? CYS D 22  ? 1_555 CYS D 96  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 5 ? 
AA4 ? 5 ? 
AA5 ? 4 ? 
AA6 ? 6 ? 
AA7 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN B 3   ? SER B 7   ? GLN B 3   SER B 7   
AA1 2 LEU B 18  ? SER B 25  ? LEU B 18  SER B 25  
AA1 3 THR B 78  ? MET B 83  ? THR B 78  MET B 83  
AA1 4 PHE B 68  ? ARG B 72  ? PHE B 68  ARG B 72  
AA2 1 LEU B 11  ? VAL B 12  ? LEU B 11  VAL B 12  
AA2 2 THR B 119 ? VAL B 120 ? THR B 119 VAL B 120 
AA3 1 THR B 58  ? TYR B 60  ? THR B 58  TYR B 60  
AA3 2 GLU B 46  ? ILE B 51  ? GLU B 46  ILE B 51  
AA3 3 TYR B 33  ? GLN B 39  ? TYR B 33  GLN B 39  
AA3 4 ARG B 93  ? GLY B 99  ? ARG B 93  GLY B 99  
AA3 5 TYR B 109 ? TRP B 112 ? TYR B 109 TRP B 112 
AA4 1 THR B 58  ? TYR B 60  ? THR B 58  TYR B 60  
AA4 2 GLU B 46  ? ILE B 51  ? GLU B 46  ILE B 51  
AA4 3 TYR B 33  ? GLN B 39  ? TYR B 33  GLN B 39  
AA4 4 ARG B 93  ? GLY B 99  ? ARG B 93  GLY B 99  
AA4 5 THR B 116 ? LEU B 117 ? THR B 116 LEU B 117 
AA5 1 LEU D 4   ? SER D 7   ? LEU D 4   SER D 7   
AA5 2 LEU D 18  ? ALA D 24  ? LEU D 18  ALA D 24  
AA5 3 THR D 78  ? MET D 83  ? THR D 78  MET D 83  
AA5 4 PHE D 68  ? ASP D 73  ? PHE D 68  ASP D 73  
AA6 1 LEU D 11  ? VAL D 12  ? LEU D 11  VAL D 12  
AA6 2 THR D 116 ? VAL D 120 ? THR D 116 VAL D 120 
AA6 3 ALA D 92  ? GLY D 99  ? ALA D 92  GLY D 99  
AA6 4 TYR D 33  ? GLN D 39  ? TYR D 33  GLN D 39  
AA6 5 GLU D 46  ? ILE D 51  ? GLU D 46  ILE D 51  
AA6 6 THR D 58  ? TYR D 60  ? THR D 58  TYR D 60  
AA7 1 LEU D 11  ? VAL D 12  ? LEU D 11  VAL D 12  
AA7 2 THR D 116 ? VAL D 120 ? THR D 116 VAL D 120 
AA7 3 ALA D 92  ? GLY D 99  ? ALA D 92  GLY D 99  
AA7 4 TYR D 109 ? TRP D 112 ? TYR D 109 TRP D 112 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER B 7   ? N SER B 7   O SER B 21  ? O SER B 21  
AA1 2 3 N CYS B 22  ? N CYS B 22  O LEU B 79  ? O LEU B 79  
AA1 3 4 O TYR B 80  ? O TYR B 80  N SER B 71  ? N SER B 71  
AA2 1 2 N VAL B 12  ? N VAL B 12  O THR B 119 ? O THR B 119 
AA3 1 2 O ASN B 59  ? O ASN B 59  N LEU B 50  ? N LEU B 50  
AA3 2 3 O ALA B 49  ? O ALA B 49  N TRP B 36  ? N TRP B 36  
AA3 3 4 N PHE B 37  ? N PHE B 37  O TYR B 95  ? O TYR B 95  
AA3 4 5 N ALA B 98  ? N ALA B 98  O TYR B 111 ? O TYR B 111 
AA4 1 2 O ASN B 59  ? O ASN B 59  N LEU B 50  ? N LEU B 50  
AA4 2 3 O ALA B 49  ? O ALA B 49  N TRP B 36  ? N TRP B 36  
AA4 3 4 N PHE B 37  ? N PHE B 37  O TYR B 95  ? O TYR B 95  
AA4 4 5 N TYR B 94  ? N TYR B 94  O THR B 116 ? O THR B 116 
AA5 1 2 N SER D 7   ? N SER D 7   O SER D 21  ? O SER D 21  
AA5 2 3 N LEU D 18  ? N LEU D 18  O MET D 83  ? O MET D 83  
AA5 3 4 O TYR D 80  ? O TYR D 80  N SER D 71  ? N SER D 71  
AA6 1 2 N VAL D 12  ? N VAL D 12  O THR D 119 ? O THR D 119 
AA6 2 3 O VAL D 118 ? O VAL D 118 N ALA D 92  ? N ALA D 92  
AA6 3 4 O GLY D 99  ? O GLY D 99  N TYR D 33  ? N TYR D 33  
AA6 4 5 N TRP D 36  ? N TRP D 36  O ALA D 49  ? O ALA D 49  
AA6 5 6 N LEU D 50  ? N LEU D 50  O ASN D 59  ? O ASN D 59  
AA7 1 2 N VAL D 12  ? N VAL D 12  O THR D 119 ? O THR D 119 
AA7 2 3 O VAL D 118 ? O VAL D 118 N ALA D 92  ? N ALA D 92  
AA7 3 4 N ALA D 98  ? N ALA D 98  O TYR D 111 ? O TYR D 111 
# 
_pdbx_entry_details.entry_id                   8Y9S 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 NH2 B ARG 93  ? ? 1_555 OD2 C ASP 56 ? ? 2_546 1.49 
2 1 OE2 A GLU 119 ? ? 1_555 O   C VAL 77 ? ? 1_554 2.12 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 N  A PHE 19  ? ? CA A PHE 19  ? ? CB A PHE 19  ? ? 99.37  110.60 -11.23 1.80 N 
2  1 CB A GLU 60  ? ? CA A GLU 60  ? ? C  A GLU 60  ? ? 98.01  110.40 -12.39 2.00 N 
3  1 CB A CYS 62  ? ? CA A CYS 62  ? ? C  A CYS 62  ? ? 125.10 111.50 13.60  1.20 N 
4  1 CB A CYS 75  ? ? CA A CYS 75  ? ? C  A CYS 75  ? ? 119.46 111.50 7.96   1.20 N 
5  1 CB A CYS 90  ? ? CA A CYS 90  ? ? C  A CYS 90  ? ? 97.07  110.40 -13.33 2.00 N 
6  1 N  A PHE 134 ? ? CA A PHE 134 ? ? CB A PHE 134 ? ? 99.30  110.60 -11.30 1.80 N 
7  1 N  A TYR 150 ? ? CA A TYR 150 ? ? CB A TYR 150 ? ? 98.24  110.60 -12.36 1.80 N 
8  1 CB A CYS 168 ? ? CA A CYS 168 ? ? C  A CYS 168 ? ? 124.79 111.50 13.29  1.20 N 
9  1 CB A CYS 253 ? ? CA A CYS 253 ? ? C  A CYS 253 ? ? 92.61  110.40 -17.79 2.00 N 
10 1 N  A PHE 309 ? ? CA A PHE 309 ? ? CB A PHE 309 ? ? 95.56  110.60 -15.04 1.80 N 
11 1 N  A TYR 370 ? ? CA A TYR 370 ? ? CB A TYR 370 ? ? 124.97 110.60 14.37  1.80 N 
12 1 CA A TYR 370 ? ? CB A TYR 370 ? ? CG A TYR 370 ? ? 127.97 113.40 14.57  1.90 N 
13 1 CB A CYS 461 ? ? CA A CYS 461 ? ? C  A CYS 461 ? ? 118.74 111.50 7.24   1.20 N 
14 1 CB A ARG 484 ? ? CA A ARG 484 ? ? C  A ARG 484 ? ? 93.37  110.40 -17.03 2.00 N 
15 1 CB C CYS 62  ? ? CA C CYS 62  ? ? C  C CYS 62  ? ? 126.76 111.50 15.26  1.20 N 
16 1 CB C CYS 90  ? ? CA C CYS 90  ? ? C  C CYS 90  ? ? 97.06  110.40 -13.34 2.00 N 
17 1 N  C GLU 95  ? ? CA C GLU 95  ? ? CB C GLU 95  ? ? 98.44  110.60 -12.16 1.80 N 
18 1 N  C PRO 96  ? ? CA C PRO 96  ? ? C  C PRO 96  ? ? 95.74  112.10 -16.36 2.60 N 
19 1 CB C CYS 253 ? ? CA C CYS 253 ? ? C  C CYS 253 ? ? 95.25  110.40 -15.15 2.00 N 
20 1 CA C TYR 370 ? ? CB C TYR 370 ? ? CG C TYR 370 ? ? 127.62 113.40 14.22  1.90 N 
21 1 N  C PRO 447 ? ? CA C PRO 447 ? ? CB C PRO 447 ? ? 94.84  103.30 -8.46  1.20 N 
22 1 N  C PRO 468 ? ? CA C PRO 468 ? ? CB C PRO 468 ? ? 95.50  103.30 -7.80  1.20 N 
23 1 CG C MET 548 ? ? SD C MET 548 ? ? CE C MET 548 ? ? 115.52 100.20 15.32  1.60 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 CYS A 34  ? ? -173.97 125.38 
2  1 ASN A 61  ? ? 83.52   -1.06  
3  1 GLN A 104 ? ? 79.20   -9.83  
4  1 GLU A 131 ? ? 71.23   -59.56 
5  1 LEU A 250 ? ? 80.32   -3.45  
6  1 ILE A 271 ? ? -137.25 -67.54 
7  1 PRO A 282 ? ? -58.69  171.42 
8  1 ASP A 301 ? ? 65.29   60.79  
9  1 LYS A 372 ? ? -99.04  42.17  
10 1 THR A 478 ? ? -149.09 31.50  
11 1 ASN B 74  ? ? 73.33   -57.17 
12 1 LEU B 102 ? ? -96.20  44.37  
13 1 GLN C 32  ? ? -73.91  -71.06 
14 1 CYS C 34  ? ? -172.38 127.80 
15 1 ASN C 61  ? ? 85.06   -4.25  
16 1 ARG C 114 ? ? -38.48  135.02 
17 1 GLU C 131 ? ? 70.69   -61.28 
18 1 PHE C 157 ? ? -39.42  -37.04 
19 1 ALA C 176 ? ? 80.38   4.45   
20 1 LEU C 250 ? ? 70.31   -59.77 
21 1 ILE C 271 ? ? -130.69 -62.99 
22 1 VAL C 310 ? ? -130.81 -49.88 
23 1 LYS C 313 ? ? -93.94  34.05  
24 1 LYS C 372 ? ? -91.60  37.74  
25 1 CYS C 437 ? ? 85.05   -7.54  
26 1 ARG C 484 ? ? -70.64  -70.40 
27 1 PRO C 537 ? ? -86.37  34.98  
28 1 LYS C 538 ? ? -131.71 -36.01 
29 1 LEU D 102 ? ? -88.85  46.44  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ALA 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    582 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   LEU 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    583 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            149.53 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1  1 ARG A 81  ? ? 0.076 'SIDE CHAIN' 
2  1 ARG A 144 ? ? 0.171 'SIDE CHAIN' 
3  1 ARG A 186 ? ? 0.133 'SIDE CHAIN' 
4  1 ARG A 197 ? ? 0.100 'SIDE CHAIN' 
5  1 ARG A 336 ? ? 0.120 'SIDE CHAIN' 
6  1 ARG A 337 ? ? 0.177 'SIDE CHAIN' 
7  1 ARG A 472 ? ? 0.113 'SIDE CHAIN' 
8  1 ARG A 484 ? ? 0.242 'SIDE CHAIN' 
9  1 ARG A 485 ? ? 0.095 'SIDE CHAIN' 
10 1 ARG B 19  ? ? 0.075 'SIDE CHAIN' 
11 1 ARG B 72  ? ? 0.210 'SIDE CHAIN' 
12 1 ARG B 110 ? ? 0.085 'SIDE CHAIN' 
13 1 ARG C 114 ? ? 0.152 'SIDE CHAIN' 
14 1 ARG C 218 ? ? 0.185 'SIDE CHAIN' 
15 1 ARG C 484 ? ? 0.112 'SIDE CHAIN' 
16 1 ARG C 521 ? ? 0.134 'SIDE CHAIN' 
17 1 ARG D 67  ? ? 0.094 'SIDE CHAIN' 
# 
loop_
_pdbx_validate_main_chain_plane.id 
_pdbx_validate_main_chain_plane.PDB_model_num 
_pdbx_validate_main_chain_plane.auth_comp_id 
_pdbx_validate_main_chain_plane.auth_asym_id 
_pdbx_validate_main_chain_plane.auth_seq_id 
_pdbx_validate_main_chain_plane.PDB_ins_code 
_pdbx_validate_main_chain_plane.label_alt_id 
_pdbx_validate_main_chain_plane.improper_torsion_angle 
1 1 GLU A 57 ? ? 12.02 
2 1 GLU A 57 ? ? 12.59 
3 1 GLU C 57 ? ? 10.49 
4 1 GLU C 57 ? ? 11.42 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ARG -5  ? A ARG 1   
2  1 Y 1 A GLY -4  ? A GLY 2   
3  1 Y 1 A VAL -3  ? A VAL 3   
4  1 Y 1 A PHE -2  ? A PHE 4   
5  1 Y 1 A ARG -1  ? A ARG 5   
6  1 Y 1 A ARG 0   ? A ARG 6   
7  1 Y 1 A ASP 1   ? A ASP 7   
8  1 Y 1 A ALA 2   ? A ALA 8   
9  1 Y 1 A ALA 78  ? A ALA 84  
10 1 Y 1 A THR 83  ? A THR 89  
11 1 Y 1 A TYR 84  ? A TYR 90  
12 1 Y 1 A GLY 85  ? A GLY 91  
13 1 Y 1 A GLU 86  ? A GLU 92  
14 1 Y 1 A GLU 97  ? A GLU 103 
15 1 Y 1 A ARG 98  ? A ARG 104 
16 1 Y 1 A PRO 110 ? A PRO 116 
17 1 Y 1 A GLN 170 ? A GLN 176 
18 1 Y 1 A ALA 171 ? A ALA 177 
19 1 Y 1 A ALA 172 ? A ALA 178 
20 1 Y 1 A ASP 173 ? A ASP 179 
21 1 Y 1 A LYS 174 ? A LYS 180 
22 1 Y 1 A ALA 175 ? A ALA 181 
23 1 Y 1 A LEU 178 ? A LEU 184 
24 1 Y 1 A LEU 585 ? A LEU 591 
25 1 Y 1 C ARG -5  ? C ARG 1   
26 1 Y 1 C GLY -4  ? C GLY 2   
27 1 Y 1 C VAL -3  ? C VAL 3   
28 1 Y 1 C PHE -2  ? C PHE 4   
29 1 Y 1 C ARG -1  ? C ARG 5   
30 1 Y 1 C ARG 0   ? C ARG 6   
31 1 Y 1 C ASP 1   ? C ASP 7   
32 1 Y 1 C ALA 2   ? C ALA 8   
33 1 Y 1 C ARG 81  ? C ARG 87  
34 1 Y 1 C GLU 82  ? C GLU 88  
35 1 Y 1 C THR 83  ? C THR 89  
36 1 Y 1 C TYR 84  ? C TYR 90  
37 1 Y 1 C GLY 85  ? C GLY 91  
38 1 Y 1 C GLU 86  ? C GLU 92  
39 1 Y 1 C MET 87  ? C MET 93  
40 1 Y 1 C ARG 98  ? C ARG 104 
41 1 Y 1 C GLN 170 ? C GLN 176 
42 1 Y 1 C ALA 171 ? C ALA 177 
43 1 Y 1 C ALA 172 ? C ALA 178 
44 1 Y 1 C LEU 585 ? C LEU 591 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Science Foundation (NSF, China)'         China 32070939       1 
'National Science Foundation (NSF, China)'         China 82030106       2 
'Ministry of Science and Technology (MoST, China)' China 2021YFA0805200 3 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 1n5u ? 
2 ? 'experimental model' PDB 1e7a ? 
# 
_atom_sites.entry_id                    8Y9S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015323 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002765 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006949 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010848 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1     N N   . HIS A 1 9   ? 5.288   -29.382 -7.982  1.00 136.62 ? 3   HIS A N   1 
ATOM 2     C CA  . HIS A 1 9   ? 5.501   -28.417 -9.097  1.00 125.44 ? 3   HIS A CA  1 
ATOM 3     C C   . HIS A 1 9   ? 6.394   -29.062 -10.162 1.00 111.35 ? 3   HIS A C   1 
ATOM 4     O O   . HIS A 1 9   ? 7.587   -29.299 -9.954  1.00 88.53  ? 3   HIS A O   1 
ATOM 5     C CB  . HIS A 1 9   ? 5.979   -27.061 -8.552  1.00 120.58 ? 3   HIS A CB  1 
ATOM 6     C CG  . HIS A 1 9   ? 7.309   -27.061 -7.856  1.00 127.72 ? 3   HIS A CG  1 
ATOM 7     N ND1 . HIS A 1 9   ? 7.448   -26.964 -6.487  1.00 129.55 ? 3   HIS A ND1 1 
ATOM 8     C CD2 . HIS A 1 9   ? 8.562   -27.091 -8.342  1.00 134.21 ? 3   HIS A CD2 1 
ATOM 9     C CE1 . HIS A 1 9   ? 8.738   -26.963 -6.167  1.00 124.56 ? 3   HIS A CE1 1 
ATOM 10    N NE2 . HIS A 1 9   ? 9.433   -27.042 -7.278  1.00 129.79 ? 3   HIS A NE2 1 
ATOM 11    N N   . LYS A 1 10  ? 5.792   -29.371 -11.314 1.00 96.31  ? 4   LYS A N   1 
ATOM 12    C CA  . LYS A 1 10  ? 6.549   -29.852 -12.452 1.00 96.46  ? 4   LYS A CA  1 
ATOM 13    C C   . LYS A 1 10  ? 7.075   -28.646 -13.226 1.00 102.40 ? 4   LYS A C   1 
ATOM 14    O O   . LYS A 1 10  ? 8.261   -28.566 -13.540 1.00 105.93 ? 4   LYS A O   1 
ATOM 15    C CB  . LYS A 1 10  ? 5.649   -30.722 -13.332 1.00 99.74  ? 4   LYS A CB  1 
ATOM 16    C CG  . LYS A 1 10  ? 4.911   -31.838 -12.606 1.00 100.81 ? 4   LYS A CG  1 
ATOM 17    C CD  . LYS A 1 10  ? 3.875   -32.576 -13.448 1.00 99.53  ? 4   LYS A CD  1 
ATOM 18    C CE  . LYS A 1 10  ? 2.737   -31.716 -13.923 1.00 99.78  ? 4   LYS A CE  1 
ATOM 19    N NZ  . LYS A 1 10  ? 1.984   -31.069 -12.847 1.00 97.35  ? 4   LYS A NZ  1 
ATOM 20    N N   . SER A 1 11  ? 6.164   -27.712 -13.522 1.00 98.89  ? 5   SER A N   1 
ATOM 21    C CA  . SER A 1 11  ? 6.492   -26.481 -14.221 1.00 100.89 ? 5   SER A CA  1 
ATOM 22    C C   . SER A 1 11  ? 7.025   -25.451 -13.227 1.00 97.37  ? 5   SER A C   1 
ATOM 23    O O   . SER A 1 11  ? 6.249   -24.892 -12.457 1.00 103.44 ? 5   SER A O   1 
ATOM 24    C CB  . SER A 1 11  ? 5.271   -25.961 -14.965 1.00 105.08 ? 5   SER A CB  1 
ATOM 25    O OG  . SER A 1 11  ? 5.481   -24.679 -15.545 1.00 102.30 ? 5   SER A OG  1 
ATOM 26    N N   . GLU A 1 12  ? 8.345   -25.208 -13.253 1.00 88.34  ? 6   GLU A N   1 
ATOM 27    C CA  . GLU A 1 12  ? 8.961   -24.162 -12.444 1.00 83.51  ? 6   GLU A CA  1 
ATOM 28    C C   . GLU A 1 12  ? 8.405   -22.783 -12.813 1.00 72.17  ? 6   GLU A C   1 
ATOM 29    O O   . GLU A 1 12  ? 7.939   -22.039 -11.949 1.00 63.41  ? 6   GLU A O   1 
ATOM 30    C CB  . GLU A 1 12  ? 10.487  -24.216 -12.566 1.00 81.85  ? 6   GLU A CB  1 
ATOM 31    C CG  . GLU A 1 12  ? 11.146  -24.978 -11.421 1.00 85.68  ? 6   GLU A CG  1 
ATOM 32    C CD  . GLU A 1 12  ? 11.151  -24.186 -10.124 1.00 87.78  ? 6   GLU A CD  1 
ATOM 33    O OE1 . GLU A 1 12  ? 12.016  -23.284 -10.005 1.00 82.05  ? 6   GLU A OE1 1 
ATOM 34    O OE2 . GLU A 1 12  ? 10.274  -24.443 -9.263  1.00 82.57  ? 6   GLU A OE2 1 
ATOM 35    N N   . VAL A 1 13  ? 8.454   -22.448 -14.105 1.00 65.35  ? 7   VAL A N   1 
ATOM 36    C CA  . VAL A 1 13  ? 7.938   -21.175 -14.577 1.00 65.00  ? 7   VAL A CA  1 
ATOM 37    C C   . VAL A 1 13  ? 6.588   -20.919 -13.909 1.00 61.57  ? 7   VAL A C   1 
ATOM 38    O O   . VAL A 1 13  ? 6.363   -19.834 -13.394 1.00 68.63  ? 7   VAL A O   1 
ATOM 39    C CB  . VAL A 1 13  ? 7.829   -21.047 -16.111 1.00 67.69  ? 7   VAL A CB  1 
ATOM 40    C CG1 . VAL A 1 13  ? 9.192   -20.861 -16.767 1.00 63.74  ? 7   VAL A CG1 1 
ATOM 41    C CG2 . VAL A 1 13  ? 7.088   -22.219 -16.750 1.00 74.85  ? 7   VAL A CG2 1 
ATOM 42    N N   . ALA A 1 14  ? 5.704   -21.919 -13.880 1.00 59.96  ? 8   ALA A N   1 
ATOM 43    C CA  . ALA A 1 14  ? 4.345   -21.708 -13.401 1.00 63.00  ? 8   ALA A CA  1 
ATOM 44    C C   . ALA A 1 14  ? 4.310   -21.616 -11.876 1.00 62.36  ? 8   ALA A C   1 
ATOM 45    O O   . ALA A 1 14  ? 3.421   -20.976 -11.319 1.00 58.05  ? 8   ALA A O   1 
ATOM 46    C CB  . ALA A 1 14  ? 3.443   -22.808 -13.905 1.00 68.85  ? 8   ALA A CB  1 
ATOM 47    N N   . HIS A 1 15  ? 5.276   -22.265 -11.213 1.00 66.50  ? 9   HIS A N   1 
ATOM 48    C CA  . HIS A 1 15  ? 5.458   -22.132 -9.775  1.00 68.24  ? 9   HIS A CA  1 
ATOM 49    C C   . HIS A 1 15  ? 5.860   -20.701 -9.429  1.00 69.94  ? 9   HIS A C   1 
ATOM 50    O O   . HIS A 1 15  ? 5.455   -20.176 -8.393  1.00 73.29  ? 9   HIS A O   1 
ATOM 51    C CB  . HIS A 1 15  ? 6.535   -23.085 -9.248  1.00 67.75  ? 9   HIS A CB  1 
ATOM 52    C CG  . HIS A 1 15  ? 6.698   -23.009 -7.768  1.00 71.68  ? 9   HIS A CG  1 
ATOM 53    N ND1 . HIS A 1 15  ? 7.926   -23.040 -7.138  1.00 78.84  ? 9   HIS A ND1 1 
ATOM 54    C CD2 . HIS A 1 15  ? 5.785   -22.875 -6.804  1.00 70.32  ? 9   HIS A CD2 1 
ATOM 55    C CE1 . HIS A 1 15  ? 7.750   -22.944 -5.830  1.00 79.05  ? 9   HIS A CE1 1 
ATOM 56    N NE2 . HIS A 1 15  ? 6.456   -22.842 -5.608  1.00 82.97  ? 9   HIS A NE2 1 
ATOM 57    N N   . ARG A 1 16  ? 6.665   -20.086 -10.301 1.00 63.00  ? 10  ARG A N   1 
ATOM 58    C CA  . ARG A 1 16  ? 7.104   -18.720 -10.094 1.00 59.58  ? 10  ARG A CA  1 
ATOM 59    C C   . ARG A 1 16  ? 6.024   -17.742 -10.537 1.00 62.17  ? 10  ARG A C   1 
ATOM 60    O O   . ARG A 1 16  ? 5.739   -16.796 -9.804  1.00 63.74  ? 10  ARG A O   1 
ATOM 61    C CB  . ARG A 1 16  ? 8.424   -18.508 -10.832 1.00 59.30  ? 10  ARG A CB  1 
ATOM 62    C CG  . ARG A 1 16  ? 9.474   -19.512 -10.393 1.00 61.28  ? 10  ARG A CG  1 
ATOM 63    C CD  . ARG A 1 16  ? 9.427   -19.668 -8.887  1.00 66.75  ? 10  ARG A CD  1 
ATOM 64    N NE  . ARG A 1 16  ? 10.528  -20.478 -8.363  1.00 74.03  ? 10  ARG A NE  1 
ATOM 65    C CZ  . ARG A 1 16  ? 10.642  -20.835 -7.091  1.00 75.10  ? 10  ARG A CZ  1 
ATOM 66    N NH1 . ARG A 1 16  ? 9.767   -20.409 -6.195  1.00 71.87  ? 10  ARG A NH1 1 
ATOM 67    N NH2 . ARG A 1 16  ? 11.639  -21.617 -6.718  1.00 76.91  ? 10  ARG A NH2 1 
ATOM 68    N N   . PHE A 1 17  ? 5.451   -17.973 -11.730 1.00 62.81  ? 11  PHE A N   1 
ATOM 69    C CA  . PHE A 1 17  ? 4.451   -17.081 -12.297 1.00 65.51  ? 11  PHE A CA  1 
ATOM 70    C C   . PHE A 1 17  ? 3.307   -16.932 -11.299 1.00 67.57  ? 11  PHE A C   1 
ATOM 71    O O   . PHE A 1 17  ? 2.815   -15.828 -11.077 1.00 64.42  ? 11  PHE A O   1 
ATOM 72    C CB  . PHE A 1 17  ? 3.931   -17.576 -13.650 1.00 69.63  ? 11  PHE A CB  1 
ATOM 73    C CG  . PHE A 1 17  ? 3.117   -16.530 -14.395 1.00 79.96  ? 11  PHE A CG  1 
ATOM 74    C CD1 . PHE A 1 17  ? 3.744   -15.580 -15.202 1.00 88.38  ? 11  PHE A CD1 1 
ATOM 75    C CD2 . PHE A 1 17  ? 1.732   -16.483 -14.268 1.00 89.68  ? 11  PHE A CD2 1 
ATOM 76    C CE1 . PHE A 1 17  ? 3.002   -14.611 -15.867 1.00 95.63  ? 11  PHE A CE1 1 
ATOM 77    C CE2 . PHE A 1 17  ? 0.993   -15.514 -14.936 1.00 102.70 ? 11  PHE A CE2 1 
ATOM 78    C CZ  . PHE A 1 17  ? 1.627   -14.582 -15.738 1.00 103.73 ? 11  PHE A CZ  1 
ATOM 79    N N   . LYS A 1 18  ? 2.919   -18.055 -10.682 1.00 67.54  ? 12  LYS A N   1 
ATOM 80    C CA  . LYS A 1 18  ? 1.832   -18.067 -9.721  1.00 67.32  ? 12  LYS A CA  1 
ATOM 81    C C   . LYS A 1 18  ? 2.221   -17.249 -8.485  1.00 67.24  ? 12  LYS A C   1 
ATOM 82    O O   . LYS A 1 18  ? 1.466   -16.372 -8.074  1.00 65.29  ? 12  LYS A O   1 
ATOM 83    C CB  . LYS A 1 18  ? 1.432   -19.521 -9.432  1.00 70.37  ? 12  LYS A CB  1 
ATOM 84    C CG  . LYS A 1 18  ? 0.589   -20.223 -10.509 1.00 72.74  ? 12  LYS A CG  1 
ATOM 85    C CD  . LYS A 1 18  ? 0.062   -21.592 -10.081 1.00 81.00  ? 12  LYS A CD  1 
ATOM 86    C CE  . LYS A 1 18  ? -0.765  -22.334 -11.099 1.00 82.64  ? 12  LYS A CE  1 
ATOM 87    N NZ  . LYS A 1 18  ? 0.024   -23.064 -12.099 1.00 81.17  ? 12  LYS A NZ  1 
ATOM 88    N N   . ASP A 1 19  ? 3.360   -17.581 -7.891  1.00 71.22  ? 13  ASP A N   1 
ATOM 89    C CA  . ASP A 1 19  ? 3.781   -16.930 -6.627  1.00 68.93  ? 13  ASP A CA  1 
ATOM 90    C C   . ASP A 1 19  ? 4.097   -15.461 -6.867  1.00 74.92  ? 13  ASP A C   1 
ATOM 91    O O   . ASP A 1 19  ? 3.455   -14.613 -6.232  1.00 80.05  ? 13  ASP A O   1 
ATOM 92    C CB  . ASP A 1 19  ? 4.994   -17.637 -6.053  1.00 68.38  ? 13  ASP A CB  1 
ATOM 93    C CG  . ASP A 1 19  ? 4.768   -19.043 -5.521  1.00 71.56  ? 13  ASP A CG  1 
ATOM 94    O OD1 . ASP A 1 19  ? 3.615   -19.507 -5.568  1.00 83.89  ? 13  ASP A OD1 1 
ATOM 95    O OD2 . ASP A 1 19  ? 5.748   -19.656 -5.061  1.00 71.38  ? 13  ASP A OD2 1 
ATOM 96    N N   . LEU A 1 20  ? 5.064   -15.177 -7.733  1.00 78.70  ? 14  LEU A N   1 
ATOM 97    C CA  . LEU A 1 20  ? 5.509   -13.779 -7.948  1.00 73.49  ? 14  LEU A CA  1 
ATOM 98    C C   . LEU A 1 20  ? 4.396   -12.893 -8.518  1.00 77.31  ? 14  LEU A C   1 
ATOM 99    O O   . LEU A 1 20  ? 4.272   -11.753 -8.051  1.00 86.36  ? 14  LEU A O   1 
ATOM 100   C CB  . LEU A 1 20  ? 6.709   -13.875 -8.883  1.00 68.28  ? 14  LEU A CB  1 
ATOM 101   C CG  . LEU A 1 20  ? 7.945   -14.575 -8.316  1.00 66.97  ? 14  LEU A CG  1 
ATOM 102   C CD1 . LEU A 1 20  ? 9.046   -14.568 -9.352  1.00 65.59  ? 14  LEU A CD1 1 
ATOM 103   C CD2 . LEU A 1 20  ? 8.390   -13.851 -7.064  1.00 69.00  ? 14  LEU A CD2 1 
ATOM 104   N N   . GLY A 1 21  ? 3.605   -13.395 -9.457  1.00 72.64  ? 15  GLY A N   1 
ATOM 105   C CA  . GLY A 1 21  ? 2.590   -12.574 -10.145 1.00 76.45  ? 15  GLY A CA  1 
ATOM 106   C C   . GLY A 1 21  ? 3.184   -12.009 -11.414 1.00 78.21  ? 15  GLY A C   1 
ATOM 107   O O   . GLY A 1 21  ? 4.420   -11.935 -11.489 1.00 84.28  ? 15  GLY A O   1 
ATOM 108   N N   . GLU A 1 22  ? 2.362   -11.605 -12.380 1.00 86.09  ? 16  GLU A N   1 
ATOM 109   C CA  . GLU A 1 22  ? 2.939   -11.194 -13.688 1.00 92.79  ? 16  GLU A CA  1 
ATOM 110   C C   . GLU A 1 22  ? 3.843   -9.971  -13.631 1.00 83.36  ? 16  GLU A C   1 
ATOM 111   O O   . GLU A 1 22  ? 4.905   -9.992  -14.272 1.00 64.59  ? 16  GLU A O   1 
ATOM 112   C CB  . GLU A 1 22  ? 1.816   -10.806 -14.647 1.00 102.05 ? 16  GLU A CB  1 
ATOM 113   C CG  . GLU A 1 22  ? 2.154   -9.658  -15.594 1.00 101.41 ? 16  GLU A CG  1 
ATOM 114   C CD  . GLU A 1 22  ? 0.933   -8.974  -16.179 1.00 105.38 ? 16  GLU A CD  1 
ATOM 115   O OE1 . GLU A 1 22  ? 0.763   -7.757  -15.959 1.00 95.40  ? 16  GLU A OE1 1 
ATOM 116   O OE2 . GLU A 1 22  ? 0.151   -9.667  -16.859 1.00 117.75 ? 16  GLU A OE2 1 
ATOM 117   N N   . GLU A 1 23  ? 3.448   -8.950  -12.877 1.00 84.24  ? 17  GLU A N   1 
ATOM 118   C CA  . GLU A 1 23  ? 4.289   -7.743  -12.968 1.00 83.87  ? 17  GLU A CA  1 
ATOM 119   C C   . GLU A 1 23  ? 5.694   -8.006  -12.457 1.00 78.84  ? 17  GLU A C   1 
ATOM 120   O O   . GLU A 1 23  ? 6.663   -7.643  -13.138 1.00 69.66  ? 17  GLU A O   1 
ATOM 121   C CB  . GLU A 1 23  ? 3.681   -6.746  -11.990 1.00 83.11  ? 17  GLU A CB  1 
ATOM 122   C CG  . GLU A 1 23  ? 3.020   -5.550  -12.665 1.00 88.01  ? 17  GLU A CG  1 
ATOM 123   C CD  . GLU A 1 23  ? 3.130   -4.292  -11.828 1.00 93.03  ? 17  GLU A CD  1 
ATOM 124   O OE1 . GLU A 1 23  ? 3.355   -4.423  -10.609 1.00 94.15  ? 17  GLU A OE1 1 
ATOM 125   O OE2 . GLU A 1 23  ? 2.993   -3.188  -12.390 1.00 97.02  ? 17  GLU A OE2 1 
ATOM 126   N N   . ASN A 1 24  ? 5.770   -8.699  -11.333 1.00 78.31  ? 18  ASN A N   1 
ATOM 127   C CA  . ASN A 1 24  ? 7.095   -8.969  -10.737 1.00 72.84  ? 18  ASN A CA  1 
ATOM 128   C C   . ASN A 1 24  ? 7.887   -9.855  -11.683 1.00 70.08  ? 18  ASN A C   1 
ATOM 129   O O   . ASN A 1 24  ? 9.080   -9.605  -11.888 1.00 74.81  ? 18  ASN A O   1 
ATOM 130   C CB  . ASN A 1 24  ? 6.947   -9.488  -9.316  1.00 74.26  ? 18  ASN A CB  1 
ATOM 131   C CG  . ASN A 1 24  ? 6.695   -8.371  -8.333  1.00 74.49  ? 18  ASN A CG  1 
ATOM 132   O OD1 . ASN A 1 24  ? 6.309   -8.627  -7.189  1.00 77.19  ? 18  ASN A OD1 1 
ATOM 133   N ND2 . ASN A 1 24  ? 6.906   -7.134  -8.756  1.00 73.90  ? 18  ASN A ND2 1 
ATOM 134   N N   . PHE A 1 25  ? 7.217   -10.846 -12.255 1.00 68.06  ? 19  PHE A N   1 
ATOM 135   C CA  . PHE A 1 25  ? 8.015   -11.787 -13.060 1.00 72.77  ? 19  PHE A CA  1 
ATOM 136   C C   . PHE A 1 25  ? 8.620   -11.087 -14.213 1.00 69.62  ? 19  PHE A C   1 
ATOM 137   O O   . PHE A 1 25  ? 9.813   -11.248 -14.481 1.00 58.80  ? 19  PHE A O   1 
ATOM 138   C CB  . PHE A 1 25  ? 6.902   -12.733 -13.513 1.00 76.95  ? 19  PHE A CB  1 
ATOM 139   C CG  . PHE A 1 25  ? 7.054   -13.563 -14.786 1.00 77.83  ? 19  PHE A CG  1 
ATOM 140   C CD1 . PHE A 1 25  ? 7.706   -13.093 -15.920 1.00 77.09  ? 19  PHE A CD1 1 
ATOM 141   C CD2 . PHE A 1 25  ? 6.494   -14.826 -14.861 1.00 73.06  ? 19  PHE A CD2 1 
ATOM 142   C CE1 . PHE A 1 25  ? 7.837   -13.870 -17.055 1.00 79.85  ? 19  PHE A CE1 1 
ATOM 143   C CE2 . PHE A 1 25  ? 6.648   -15.612 -15.991 1.00 71.67  ? 19  PHE A CE2 1 
ATOM 144   C CZ  . PHE A 1 25  ? 7.301   -15.128 -17.090 1.00 74.92  ? 19  PHE A CZ  1 
ATOM 145   N N   . LYS A 1 26  ? 7.826   -10.244 -14.857 1.00 65.78  ? 20  LYS A N   1 
ATOM 146   C CA  . LYS A 1 26  ? 8.370   -9.651  -16.090 1.00 65.29  ? 20  LYS A CA  1 
ATOM 147   C C   . LYS A 1 26  ? 9.568   -8.802  -15.711 1.00 59.89  ? 20  LYS A C   1 
ATOM 148   O O   . LYS A 1 26  ? 10.582  -8.843  -16.413 1.00 54.64  ? 20  LYS A O   1 
ATOM 149   C CB  . LYS A 1 26  ? 7.256   -8.858  -16.769 1.00 72.80  ? 20  LYS A CB  1 
ATOM 150   C CG  . LYS A 1 26  ? 6.109   -9.682  -17.322 1.00 79.19  ? 20  LYS A CG  1 
ATOM 151   C CD  . LYS A 1 26  ? 4.959   -8.812  -17.810 1.00 79.87  ? 20  LYS A CD  1 
ATOM 152   C CE  . LYS A 1 26  ? 5.012   -8.575  -19.281 1.00 88.78  ? 20  LYS A CE  1 
ATOM 153   N NZ  . LYS A 1 26  ? 3.753   -8.015  -19.775 1.00 98.79  ? 20  LYS A NZ  1 
ATOM 154   N N   . ALA A 1 27  ? 9.421   -8.062  -14.622 1.00 54.87  ? 21  ALA A N   1 
ATOM 155   C CA  . ALA A 1 27  ? 10.516  -7.165  -14.247 1.00 52.33  ? 21  ALA A CA  1 
ATOM 156   C C   . ALA A 1 27  ? 11.731  -8.000  -13.917 1.00 54.82  ? 21  ALA A C   1 
ATOM 157   O O   . ALA A 1 27  ? 12.845  -7.683  -14.328 1.00 54.91  ? 21  ALA A O   1 
ATOM 158   C CB  . ALA A 1 27  ? 10.079  -6.400  -13.059 1.00 54.99  ? 21  ALA A CB  1 
ATOM 159   N N   . LEU A 1 28  ? 11.485  -9.080  -13.199 1.00 60.02  ? 22  LEU A N   1 
ATOM 160   C CA  . LEU A 1 28  ? 12.626  -9.912  -12.773 1.00 66.12  ? 22  LEU A CA  1 
ATOM 161   C C   . LEU A 1 28  ? 13.298  -10.487 -14.009 1.00 62.13  ? 22  LEU A C   1 
ATOM 162   O O   . LEU A 1 28  ? 14.524  -10.451 -14.093 1.00 62.03  ? 22  LEU A O   1 
ATOM 163   C CB  . LEU A 1 28  ? 12.087  -10.997 -11.847 1.00 73.10  ? 22  LEU A CB  1 
ATOM 164   C CG  . LEU A 1 28  ? 12.358  -10.818 -10.354 1.00 70.91  ? 22  LEU A CG  1 
ATOM 165   C CD1 . LEU A 1 28  ? 13.108  -9.530  -10.116 1.00 64.54  ? 22  LEU A CD1 1 
ATOM 166   C CD2 . LEU A 1 28  ? 11.026  -10.804 -9.642  1.00 72.27  ? 22  LEU A CD2 1 
ATOM 167   N N   . VAL A 1 29  ? 12.493  -10.996 -14.928 1.00 57.92  ? 23  VAL A N   1 
ATOM 168   C CA  . VAL A 1 29  ? 13.040  -11.626 -16.156 1.00 54.61  ? 23  VAL A CA  1 
ATOM 169   C C   . VAL A 1 29  ? 13.822  -10.562 -16.921 1.00 50.20  ? 23  VAL A C   1 
ATOM 170   O O   . VAL A 1 29  ? 14.923  -10.864 -17.391 1.00 40.88  ? 23  VAL A O   1 
ATOM 171   C CB  . VAL A 1 29  ? 11.878  -12.214 -16.972 1.00 56.89  ? 23  VAL A CB  1 
ATOM 172   C CG1 . VAL A 1 29  ? 12.293  -12.562 -18.393 1.00 66.31  ? 23  VAL A CG1 1 
ATOM 173   C CG2 . VAL A 1 29  ? 11.271  -13.429 -16.288 1.00 54.44  ? 23  VAL A CG2 1 
ATOM 174   N N   . LEU A 1 30  ? 13.272  -9.359  -16.998 1.00 48.15  ? 24  LEU A N   1 
ATOM 175   C CA  . LEU A 1 30  ? 13.944  -8.299  -17.772 1.00 49.39  ? 24  LEU A CA  1 
ATOM 176   C C   . LEU A 1 30  ? 15.279  -8.044  -17.099 1.00 47.99  ? 24  LEU A C   1 
ATOM 177   O O   . LEU A 1 30  ? 16.286  -7.909  -17.803 1.00 45.81  ? 24  LEU A O   1 
ATOM 178   C CB  . LEU A 1 30  ? 13.069  -7.054  -17.706 1.00 49.66  ? 24  LEU A CB  1 
ATOM 179   C CG  . LEU A 1 30  ? 13.138  -6.062  -18.869 1.00 50.28  ? 24  LEU A CG  1 
ATOM 180   C CD1 . LEU A 1 30  ? 12.478  -4.773  -18.432 1.00 49.07  ? 24  LEU A CD1 1 
ATOM 181   C CD2 . LEU A 1 30  ? 14.550  -5.787  -19.335 1.00 54.63  ? 24  LEU A CD2 1 
ATOM 182   N N   . ILE A 1 31  ? 15.277  -8.027  -15.776 1.00 46.46  ? 25  ILE A N   1 
ATOM 183   C CA  . ILE A 1 31  ? 16.543  -7.672  -15.097 1.00 45.03  ? 25  ILE A CA  1 
ATOM 184   C C   . ILE A 1 31  ? 17.547  -8.745  -15.468 1.00 48.22  ? 25  ILE A C   1 
ATOM 185   O O   . ILE A 1 31  ? 18.649  -8.402  -15.886 1.00 47.37  ? 25  ILE A O   1 
ATOM 186   C CB  . ILE A 1 31  ? 16.327  -7.631  -13.580 1.00 43.83  ? 25  ILE A CB  1 
ATOM 187   C CG1 . ILE A 1 31  ? 15.752  -6.289  -13.132 1.00 41.32  ? 25  ILE A CG1 1 
ATOM 188   C CG2 . ILE A 1 31  ? 17.610  -7.980  -12.829 1.00 42.11  ? 25  ILE A CG2 1 
ATOM 189   C CD1 . ILE A 1 31  ? 14.724  -6.394  -12.022 1.00 38.67  ? 25  ILE A CD1 1 
ATOM 190   N N   . ALA A 1 32  ? 17.107  -9.989  -15.460 1.00 50.50  ? 26  ALA A N   1 
ATOM 191   C CA  . ALA A 1 32  ? 18.113  -11.027 -15.701 1.00 49.42  ? 26  ALA A CA  1 
ATOM 192   C C   . ALA A 1 32  ? 18.695  -10.878 -17.093 1.00 51.51  ? 26  ALA A C   1 
ATOM 193   O O   . ALA A 1 32  ? 19.913  -10.963 -17.252 1.00 51.81  ? 26  ALA A O   1 
ATOM 194   C CB  . ALA A 1 32  ? 17.417  -12.333 -15.569 1.00 47.51  ? 26  ALA A CB  1 
ATOM 195   N N   . PHE A 1 33  ? 17.827  -10.624 -18.063 1.00 54.58  ? 27  PHE A N   1 
ATOM 196   C CA  . PHE A 1 33  ? 18.304  -10.481 -19.455 1.00 56.66  ? 27  PHE A CA  1 
ATOM 197   C C   . PHE A 1 33  ? 19.197  -9.287  -19.539 1.00 54.01  ? 27  PHE A C   1 
ATOM 198   O O   . PHE A 1 33  ? 20.266  -9.341  -20.161 1.00 52.61  ? 27  PHE A O   1 
ATOM 199   C CB  . PHE A 1 33  ? 17.062  -10.351 -20.333 1.00 58.41  ? 27  PHE A CB  1 
ATOM 200   C CG  . PHE A 1 33  ? 16.257  -11.616 -20.592 1.00 62.11  ? 27  PHE A CG  1 
ATOM 201   C CD1 . PHE A 1 33  ? 16.736  -12.864 -20.221 1.00 60.94  ? 27  PHE A CD1 1 
ATOM 202   C CD2 . PHE A 1 33  ? 15.016  -11.548 -21.211 1.00 62.27  ? 27  PHE A CD2 1 
ATOM 203   C CE1 . PHE A 1 33  ? 15.997  -14.008 -20.468 1.00 57.50  ? 27  PHE A CE1 1 
ATOM 204   C CE2 . PHE A 1 33  ? 14.282  -12.695 -21.453 1.00 59.35  ? 27  PHE A CE2 1 
ATOM 205   C CZ  . PHE A 1 33  ? 14.773  -13.921 -21.082 1.00 57.81  ? 27  PHE A CZ  1 
ATOM 206   N N   . ALA A 1 34  ? 18.774  -8.217  -18.877 1.00 45.78  ? 28  ALA A N   1 
ATOM 207   C CA  . ALA A 1 34  ? 19.544  -6.963  -18.953 1.00 46.81  ? 28  ALA A CA  1 
ATOM 208   C C   . ALA A 1 34  ? 20.917  -7.153  -18.339 1.00 49.04  ? 28  ALA A C   1 
ATOM 209   O O   . ALA A 1 34  ? 21.912  -6.611  -18.825 1.00 44.09  ? 28  ALA A O   1 
ATOM 210   C CB  . ALA A 1 34  ? 18.774  -5.906  -18.244 1.00 45.41  ? 28  ALA A CB  1 
ATOM 211   N N   . GLN A 1 35  ? 20.926  -7.862  -17.226 1.00 51.97  ? 29  GLN A N   1 
ATOM 212   C CA  . GLN A 1 35  ? 22.198  -8.117  -16.524 1.00 55.17  ? 29  GLN A CA  1 
ATOM 213   C C   . GLN A 1 35  ? 23.080  -8.953  -17.452 1.00 63.94  ? 29  GLN A C   1 
ATOM 214   O O   . GLN A 1 35  ? 24.229  -8.658  -17.548 1.00 65.65  ? 29  GLN A O   1 
ATOM 215   C CB  . GLN A 1 35  ? 21.800  -8.631  -15.145 1.00 53.65  ? 29  GLN A CB  1 
ATOM 216   C CG  . GLN A 1 35  ? 21.184  -7.539  -14.281 1.00 52.34  ? 29  GLN A CG  1 
ATOM 217   C CD  . GLN A 1 35  ? 21.125  -7.893  -12.816 1.00 50.04  ? 29  GLN A CD  1 
ATOM 218   O OE1 . GLN A 1 35  ? 20.871  -9.039  -12.439 1.00 45.71  ? 29  GLN A OE1 1 
ATOM 219   N NE2 . GLN A 1 35  ? 21.359  -6.900  -11.975 1.00 53.18  ? 29  GLN A NE2 1 
ATOM 220   N N   . TYR A 1 36  ? 22.543  -9.929  -18.167 1.00 71.43  ? 30  TYR A N   1 
ATOM 221   C CA  . TYR A 1 36  ? 23.459  -10.728 -19.020 1.00 73.38  ? 30  TYR A CA  1 
ATOM 222   C C   . TYR A 1 36  ? 23.813  -9.935  -20.275 1.00 68.13  ? 30  TYR A C   1 
ATOM 223   O O   . TYR A 1 36  ? 24.994  -9.629  -20.481 1.00 56.98  ? 30  TYR A O   1 
ATOM 224   C CB  . TYR A 1 36  ? 22.786  -12.079 -19.273 1.00 75.34  ? 30  TYR A CB  1 
ATOM 225   C CG  . TYR A 1 36  ? 22.891  -13.088 -18.138 1.00 76.72  ? 30  TYR A CG  1 
ATOM 226   C CD1 . TYR A 1 36  ? 23.466  -12.750 -16.922 1.00 77.74  ? 30  TYR A CD1 1 
ATOM 227   C CD2 . TYR A 1 36  ? 22.414  -14.382 -18.287 1.00 80.94  ? 30  TYR A CD2 1 
ATOM 228   C CE1 . TYR A 1 36  ? 23.561  -13.668 -15.889 1.00 81.07  ? 30  TYR A CE1 1 
ATOM 229   C CE2 . TYR A 1 36  ? 22.502  -15.308 -17.263 1.00 81.77  ? 30  TYR A CE2 1 
ATOM 230   C CZ  . TYR A 1 36  ? 23.078  -14.951 -16.060 1.00 78.82  ? 30  TYR A CZ  1 
ATOM 231   O OH  . TYR A 1 36  ? 23.166  -15.863 -15.050 1.00 66.85  ? 30  TYR A OH  1 
ATOM 232   N N   . LEU A 1 37  ? 22.813  -9.600  -21.090 1.00 70.83  ? 31  LEU A N   1 
ATOM 233   C CA  . LEU A 1 37  ? 23.059  -8.863  -22.326 1.00 72.19  ? 31  LEU A CA  1 
ATOM 234   C C   . LEU A 1 37  ? 22.974  -7.351  -22.086 1.00 71.76  ? 31  LEU A C   1 
ATOM 235   O O   . LEU A 1 37  ? 21.922  -6.727  -22.274 1.00 62.67  ? 31  LEU A O   1 
ATOM 236   C CB  . LEU A 1 37  ? 22.106  -9.309  -23.438 1.00 64.07  ? 31  LEU A CB  1 
ATOM 237   C CG  . LEU A 1 37  ? 22.370  -10.676 -24.084 1.00 58.13  ? 31  LEU A CG  1 
ATOM 238   C CD1 . LEU A 1 37  ? 23.783  -11.195 -23.859 1.00 59.96  ? 31  LEU A CD1 1 
ATOM 239   C CD2 . LEU A 1 37  ? 21.357  -11.705 -23.630 1.00 56.42  ? 31  LEU A CD2 1 
ATOM 240   N N   . GLN A 1 38  ? 24.122  -6.766  -21.716 1.00 67.74  ? 32  GLN A N   1 
ATOM 241   C CA  . GLN A 1 38  ? 24.161  -5.386  -21.269 1.00 71.58  ? 32  GLN A CA  1 
ATOM 242   C C   . GLN A 1 38  ? 23.994  -4.451  -22.465 1.00 75.50  ? 32  GLN A C   1 
ATOM 243   O O   . GLN A 1 38  ? 23.049  -3.665  -22.519 1.00 79.47  ? 32  GLN A O   1 
ATOM 244   C CB  . GLN A 1 38  ? 25.466  -5.115  -20.527 1.00 68.69  ? 32  GLN A CB  1 
ATOM 245   C CG  . GLN A 1 38  ? 25.696  -5.992  -19.302 1.00 66.11  ? 32  GLN A CG  1 
ATOM 246   C CD  . GLN A 1 38  ? 26.866  -5.496  -18.475 1.00 68.09  ? 32  GLN A CD  1 
ATOM 247   O OE1 . GLN A 1 38  ? 26.867  -4.357  -17.990 1.00 76.13  ? 32  GLN A OE1 1 
ATOM 248   N NE2 . GLN A 1 38  ? 27.885  -6.329  -18.313 1.00 61.07  ? 32  GLN A NE2 1 
ATOM 249   N N   . GLN A 1 39  ? 24.922  -4.553  -23.423 1.00 77.00  ? 33  GLN A N   1 
ATOM 250   C CA  . GLN A 1 39  ? 24.879  -3.758  -24.636 1.00 73.37  ? 33  GLN A CA  1 
ATOM 251   C C   . GLN A 1 39  ? 23.911  -4.448  -25.575 1.00 67.41  ? 33  GLN A C   1 
ATOM 252   O O   . GLN A 1 39  ? 24.290  -5.391  -26.246 1.00 81.79  ? 33  GLN A O   1 
ATOM 253   C CB  . GLN A 1 39  ? 26.251  -3.693  -25.296 1.00 76.01  ? 33  GLN A CB  1 
ATOM 254   C CG  . GLN A 1 39  ? 27.333  -3.182  -24.357 1.00 87.07  ? 33  GLN A CG  1 
ATOM 255   C CD  . GLN A 1 39  ? 28.713  -3.628  -24.768 1.00 93.07  ? 33  GLN A CD  1 
ATOM 256   O OE1 . GLN A 1 39  ? 28.939  -4.802  -25.081 1.00 90.27  ? 33  GLN A OE1 1 
ATOM 257   N NE2 . GLN A 1 39  ? 29.643  -2.684  -24.770 1.00 102.89 ? 33  GLN A NE2 1 
ATOM 258   N N   . CYS A 1 40  ? 22.651  -4.032  -25.539 1.00 64.26  ? 34  CYS A N   1 
ATOM 259   C CA  . CYS A 1 40  ? 21.599  -4.747  -26.231 1.00 60.71  ? 34  CYS A CA  1 
ATOM 260   C C   . CYS A 1 40  ? 20.335  -3.908  -26.096 1.00 60.00  ? 34  CYS A C   1 
ATOM 261   O O   . CYS A 1 40  ? 19.947  -3.553  -24.984 1.00 64.21  ? 34  CYS A O   1 
ATOM 262   C CB  . CYS A 1 40  ? 21.448  -6.165  -25.684 1.00 69.27  ? 34  CYS A CB  1 
ATOM 263   S SG  . CYS A 1 40  ? 21.112  -7.416  -26.959 1.00 86.08  ? 34  CYS A SG  1 
ATOM 264   N N   . PRO A 1 41  ? 19.669  -3.553  -27.215 1.00 57.72  ? 35  PRO A N   1 
ATOM 265   C CA  . PRO A 1 41  ? 18.623  -2.533  -27.208 1.00 59.77  ? 35  PRO A CA  1 
ATOM 266   C C   . PRO A 1 41  ? 17.467  -2.900  -26.299 1.00 55.46  ? 35  PRO A C   1 
ATOM 267   O O   . PRO A 1 41  ? 17.095  -4.060  -26.242 1.00 56.88  ? 35  PRO A O   1 
ATOM 268   C CB  . PRO A 1 41  ? 18.150  -2.468  -28.668 1.00 65.94  ? 35  PRO A CB  1 
ATOM 269   C CG  . PRO A 1 41  ? 19.300  -3.046  -29.458 1.00 67.77  ? 35  PRO A CG  1 
ATOM 270   C CD  . PRO A 1 41  ? 19.877  -4.120  -28.550 1.00 65.90  ? 35  PRO A CD  1 
ATOM 271   N N   . PHE A 1 42  ? 16.880  -1.893  -25.654 1.00 56.63  ? 36  PHE A N   1 
ATOM 272   C CA  . PHE A 1 42  ? 15.644  -2.073  -24.915 1.00 66.23  ? 36  PHE A CA  1 
ATOM 273   C C   . PHE A 1 42  ? 14.642  -2.933  -25.696 1.00 71.45  ? 36  PHE A C   1 
ATOM 274   O O   . PHE A 1 42  ? 14.039  -3.858  -25.144 1.00 69.11  ? 36  PHE A O   1 
ATOM 275   C CB  . PHE A 1 42  ? 15.085  -0.686  -24.597 1.00 70.60  ? 36  PHE A CB  1 
ATOM 276   C CG  . PHE A 1 42  ? 13.775  -0.744  -23.827 1.00 72.89  ? 36  PHE A CG  1 
ATOM 277   C CD1 . PHE A 1 42  ? 13.751  -1.153  -22.499 1.00 69.50  ? 36  PHE A CD1 1 
ATOM 278   C CD2 . PHE A 1 42  ? 12.573  -0.398  -24.436 1.00 77.20  ? 36  PHE A CD2 1 
ATOM 279   C CE1 . PHE A 1 42  ? 12.555  -1.220  -21.804 1.00 75.35  ? 36  PHE A CE1 1 
ATOM 280   C CE2 . PHE A 1 42  ? 11.381  -0.455  -23.732 1.00 79.99  ? 36  PHE A CE2 1 
ATOM 281   C CZ  . PHE A 1 42  ? 11.373  -0.868  -22.420 1.00 79.26  ? 36  PHE A CZ  1 
ATOM 282   N N   . GLU A 1 43  ? 14.475  -2.647  -26.993 1.00 70.54  ? 37  GLU A N   1 
ATOM 283   C CA  . GLU A 1 43  ? 13.438  -3.298  -27.776 1.00 70.21  ? 37  GLU A CA  1 
ATOM 284   C C   . GLU A 1 43  ? 13.690  -4.800  -27.903 1.00 62.86  ? 37  GLU A C   1 
ATOM 285   O O   . GLU A 1 43  ? 12.744  -5.543  -28.126 1.00 62.27  ? 37  GLU A O   1 
ATOM 286   C CB  . GLU A 1 43  ? 13.286  -2.711  -29.179 1.00 82.91  ? 37  GLU A CB  1 
ATOM 287   C CG  . GLU A 1 43  ? 12.936  -1.225  -29.202 1.00 89.27  ? 37  GLU A CG  1 
ATOM 288   C CD  . GLU A 1 43  ? 14.135  -0.302  -29.136 1.00 93.33  ? 37  GLU A CD  1 
ATOM 289   O OE1 . GLU A 1 43  ? 15.261  -0.775  -28.858 1.00 90.36  ? 37  GLU A OE1 1 
ATOM 290   O OE2 . GLU A 1 43  ? 13.927  0.901   -29.386 1.00 104.20 ? 37  GLU A OE2 1 
ATOM 291   N N   . ASP A 1 44  ? 14.952  -5.242  -27.792 1.00 66.07  ? 38  ASP A N   1 
ATOM 292   C CA  . ASP A 1 44  ? 15.280  -6.666  -27.763 1.00 71.40  ? 38  ASP A CA  1 
ATOM 293   C C   . ASP A 1 44  ? 14.731  -7.314  -26.487 1.00 62.18  ? 38  ASP A C   1 
ATOM 294   O O   . ASP A 1 44  ? 14.026  -8.337  -26.539 1.00 53.94  ? 38  ASP A O   1 
ATOM 295   C CB  . ASP A 1 44  ? 16.783  -6.920  -27.878 1.00 74.56  ? 38  ASP A CB  1 
ATOM 296   C CG  . ASP A 1 44  ? 17.370  -7.019  -29.282 1.00 80.73  ? 38  ASP A CG  1 
ATOM 297   O OD1 . ASP A 1 44  ? 16.593  -7.220  -30.246 1.00 81.61  ? 38  ASP A OD1 1 
ATOM 298   O OD2 . ASP A 1 44  ? 18.612  -6.905  -29.402 1.00 83.77  ? 38  ASP A OD2 1 
ATOM 299   N N   . HIS A 1 45  ? 15.080  -6.707  -25.342 1.00 49.49  ? 39  HIS A N   1 
ATOM 300   C CA  . HIS A 1 45  ? 14.804  -7.312  -24.055 1.00 46.23  ? 39  HIS A CA  1 
ATOM 301   C C   . HIS A 1 45  ? 13.306  -7.440  -23.911 1.00 47.89  ? 39  HIS A C   1 
ATOM 302   O O   . HIS A 1 45  ? 12.835  -8.501  -23.522 1.00 50.21  ? 39  HIS A O   1 
ATOM 303   C CB  . HIS A 1 45  ? 15.474  -6.544  -22.920 1.00 44.79  ? 39  HIS A CB  1 
ATOM 304   C CG  . HIS A 1 45  ? 16.932  -6.815  -22.909 1.00 45.31  ? 39  HIS A CG  1 
ATOM 305   N ND1 . HIS A 1 45  ? 17.451  -8.093  -22.920 1.00 44.90  ? 39  HIS A ND1 1 
ATOM 306   C CD2 . HIS A 1 45  ? 17.973  -5.982  -22.921 1.00 45.26  ? 39  HIS A CD2 1 
ATOM 307   C CE1 . HIS A 1 45  ? 18.772  -8.016  -22.927 1.00 47.60  ? 39  HIS A CE1 1 
ATOM 308   N NE2 . HIS A 1 45  ? 19.115  -6.738  -22.930 1.00 47.50  ? 39  HIS A NE2 1 
ATOM 309   N N   . VAL A 1 46  ? 12.604  -6.367  -24.294 1.00 51.94  ? 40  VAL A N   1 
ATOM 310   C CA  . VAL A 1 46  ? 11.153  -6.323  -24.248 1.00 54.13  ? 40  VAL A CA  1 
ATOM 311   C C   . VAL A 1 46  ? 10.593  -7.518  -25.016 1.00 59.02  ? 40  VAL A C   1 
ATOM 312   O O   . VAL A 1 46  ? 9.746   -8.237  -24.483 1.00 62.71  ? 40  VAL A O   1 
ATOM 313   C CB  . VAL A 1 46  ? 10.585  -4.995  -24.783 1.00 54.90  ? 40  VAL A CB  1 
ATOM 314   C CG1 . VAL A 1 46  ? 9.060   -5.021  -24.887 1.00 57.04  ? 40  VAL A CG1 1 
ATOM 315   C CG2 . VAL A 1 46  ? 11.024  -3.812  -23.924 1.00 54.03  ? 40  VAL A CG2 1 
ATOM 316   N N   . LYS A 1 47  ? 11.090  -7.741  -26.242 1.00 57.47  ? 41  LYS A N   1 
ATOM 317   C CA  . LYS A 1 47  ? 10.602  -8.826  -27.077 1.00 57.99  ? 41  LYS A CA  1 
ATOM 318   C C   . LYS A 1 47  ? 10.763  -10.181 -26.387 1.00 59.60  ? 41  LYS A C   1 
ATOM 319   O O   . LYS A 1 47  ? 9.814   -10.961 -26.366 1.00 58.17  ? 41  LYS A O   1 
ATOM 320   C CB  . LYS A 1 47  ? 11.321  -8.935  -28.419 1.00 57.06  ? 41  LYS A CB  1 
ATOM 321   C CG  . LYS A 1 47  ? 10.497  -9.705  -29.434 1.00 61.18  ? 41  LYS A CG  1 
ATOM 322   C CD  . LYS A 1 47  ? 11.364  -10.427 -30.449 1.00 71.91  ? 41  LYS A CD  1 
ATOM 323   C CE  . LYS A 1 47  ? 10.617  -11.207 -31.482 1.00 75.00  ? 41  LYS A CE  1 
ATOM 324   N NZ  . LYS A 1 47  ? 11.609  -11.908 -32.303 1.00 85.13  ? 41  LYS A NZ  1 
ATOM 325   N N   . LEU A 1 48  ? 11.956  -10.456 -25.837 1.00 61.67  ? 42  LEU A N   1 
ATOM 326   C CA  . LEU A 1 48  ? 12.257  -11.743 -25.215 1.00 60.97  ? 42  LEU A CA  1 
ATOM 327   C C   . LEU A 1 48  ? 11.343  -11.995 -24.025 1.00 59.87  ? 42  LEU A C   1 
ATOM 328   O O   . LEU A 1 48  ? 10.865  -13.109 -23.843 1.00 60.20  ? 42  LEU A O   1 
ATOM 329   C CB  . LEU A 1 48  ? 13.710  -11.807 -24.758 1.00 61.11  ? 42  LEU A CB  1 
ATOM 330   C CG  . LEU A 1 48  ? 14.754  -11.518 -25.838 1.00 66.77  ? 42  LEU A CG  1 
ATOM 331   C CD1 . LEU A 1 48  ? 16.157  -11.797 -25.324 1.00 70.06  ? 42  LEU A CD1 1 
ATOM 332   C CD2 . LEU A 1 48  ? 14.468  -12.323 -27.101 1.00 69.02  ? 42  LEU A CD2 1 
ATOM 333   N N   . VAL A 1 49  ? 11.136  -10.953 -23.216 1.00 61.68  ? 43  VAL A N   1 
ATOM 334   C CA  . VAL A 1 49  ? 10.345  -11.061 -22.005 1.00 62.37  ? 43  VAL A CA  1 
ATOM 335   C C   . VAL A 1 49  ? 8.905   -11.396 -22.362 1.00 66.94  ? 43  VAL A C   1 
ATOM 336   O O   . VAL A 1 49  ? 8.283   -12.189 -21.668 1.00 79.11  ? 43  VAL A O   1 
ATOM 337   C CB  . VAL A 1 49  ? 10.415  -9.780  -21.162 1.00 57.04  ? 43  VAL A CB  1 
ATOM 338   C CG1 . VAL A 1 49  ? 9.340   -9.769  -20.077 1.00 57.89  ? 43  VAL A CG1 1 
ATOM 339   C CG2 . VAL A 1 49  ? 11.813  -9.583  -20.581 1.00 55.52  ? 43  VAL A CG2 1 
ATOM 340   N N   . ASN A 1 50  ? 8.390   -10.780 -23.431 1.00 70.09  ? 44  ASN A N   1 
ATOM 341   C CA  . ASN A 1 50  ? 7.026   -11.019 -23.882 1.00 71.59  ? 44  ASN A CA  1 
ATOM 342   C C   . ASN A 1 50  ? 6.867   -12.461 -24.367 1.00 67.20  ? 44  ASN A C   1 
ATOM 343   O O   . ASN A 1 50  ? 5.798   -13.049 -24.236 1.00 74.44  ? 44  ASN A O   1 
ATOM 344   C CB  . ASN A 1 50  ? 6.607   -10.013 -24.950 1.00 70.85  ? 44  ASN A CB  1 
ATOM 345   C CG  . ASN A 1 50  ? 6.597   -8.593  -24.431 1.00 72.74  ? 44  ASN A CG  1 
ATOM 346   O OD1 . ASN A 1 50  ? 6.698   -8.359  -23.220 1.00 72.80  ? 44  ASN A OD1 1 
ATOM 347   N ND2 . ASN A 1 50  ? 6.484   -7.633  -25.334 1.00 75.90  ? 44  ASN A ND2 1 
ATOM 348   N N   . GLU A 1 51  ? 7.928   -13.043 -24.925 1.00 67.94  ? 45  GLU A N   1 
ATOM 349   C CA  . GLU A 1 51  ? 7.852   -14.408 -25.433 1.00 77.49  ? 45  GLU A CA  1 
ATOM 350   C C   . GLU A 1 51  ? 7.855   -15.404 -24.277 1.00 76.68  ? 45  GLU A C   1 
ATOM 351   O O   . GLU A 1 51  ? 7.213   -16.450 -24.366 1.00 77.82  ? 45  GLU A O   1 
ATOM 352   C CB  . GLU A 1 51  ? 8.982   -14.765 -26.402 1.00 81.62  ? 45  GLU A CB  1 
ATOM 353   C CG  . GLU A 1 51  ? 8.851   -14.075 -27.758 1.00 81.46  ? 45  GLU A CG  1 
ATOM 354   C CD  . GLU A 1 51  ? 10.054  -14.239 -28.669 1.00 88.66  ? 45  GLU A CD  1 
ATOM 355   O OE1 . GLU A 1 51  ? 11.197  -14.134 -28.175 1.00 107.47 ? 45  GLU A OE1 1 
ATOM 356   O OE2 . GLU A 1 51  ? 9.861   -14.431 -29.883 1.00 84.54  ? 45  GLU A OE2 1 
ATOM 357   N N   . VAL A 1 52  ? 8.602   -15.076 -23.216 1.00 74.31  ? 46  VAL A N   1 
ATOM 358   C CA  . VAL A 1 52  ? 8.655   -15.897 -22.016 1.00 68.27  ? 46  VAL A CA  1 
ATOM 359   C C   . VAL A 1 52  ? 7.320   -15.826 -21.277 1.00 67.60  ? 46  VAL A C   1 
ATOM 360   O O   . VAL A 1 52  ? 6.711   -16.855 -21.006 1.00 72.16  ? 46  VAL A O   1 
ATOM 361   C CB  . VAL A 1 52  ? 9.798   -15.453 -21.091 1.00 62.36  ? 46  VAL A CB  1 
ATOM 362   C CG1 . VAL A 1 52  ? 9.653   -16.084 -19.717 1.00 65.10  ? 46  VAL A CG1 1 
ATOM 363   C CG2 . VAL A 1 52  ? 11.166  -15.753 -21.692 1.00 60.89  ? 46  VAL A CG2 1 
ATOM 364   N N   . THR A 1 53  ? 6.904   -14.601 -20.935 1.00 67.34  ? 47  THR A N   1 
ATOM 365   C CA  . THR A 1 53  ? 5.633   -14.335 -20.282 1.00 66.92  ? 47  THR A CA  1 
ATOM 366   C C   . THR A 1 53  ? 4.536   -15.154 -20.949 1.00 69.60  ? 47  THR A C   1 
ATOM 367   O O   . THR A 1 53  ? 3.911   -15.973 -20.287 1.00 79.77  ? 47  THR A O   1 
ATOM 368   C CB  . THR A 1 53  ? 5.354   -12.834 -20.324 1.00 70.92  ? 47  THR A CB  1 
ATOM 369   O OG1 . THR A 1 53  ? 6.321   -12.353 -19.392 1.00 75.48  ? 47  THR A OG1 1 
ATOM 370   C CG2 . THR A 1 53  ? 3.944   -12.453 -19.908 1.00 72.21  ? 47  THR A CG2 1 
ATOM 371   N N   . GLU A 1 54  ? 4.338   -14.966 -22.259 1.00 75.88  ? 48  GLU A N   1 
ATOM 372   C CA  . GLU A 1 54  ? 3.275   -15.664 -22.968 1.00 76.86  ? 48  GLU A CA  1 
ATOM 373   C C   . GLU A 1 54  ? 3.426   -17.178 -22.774 1.00 73.16  ? 48  GLU A C   1 
ATOM 374   O O   . GLU A 1 54  ? 2.425   -17.886 -22.632 1.00 73.49  ? 48  GLU A O   1 
ATOM 375   C CB  . GLU A 1 54  ? 3.229   -15.234 -24.437 1.00 75.97  ? 48  GLU A CB  1 
ATOM 376   C CG  . GLU A 1 54  ? 2.117   -15.905 -25.245 1.00 81.02  ? 48  GLU A CG  1 
ATOM 377   C CD  . GLU A 1 54  ? 0.751   -15.976 -24.573 1.00 80.06  ? 48  GLU A CD  1 
ATOM 378   O OE1 . GLU A 1 54  ? 0.276   -14.945 -24.041 1.00 74.08  ? 48  GLU A OE1 1 
ATOM 379   O OE2 . GLU A 1 54  ? 0.167   -17.085 -24.584 1.00 78.29  ? 48  GLU A OE2 1 
ATOM 380   N N   . PHE A 1 55  ? 4.677   -17.663 -22.749 1.00 62.34  ? 49  PHE A N   1 
ATOM 381   C CA  . PHE A 1 55  ? 4.951   -19.083 -22.603 1.00 62.59  ? 49  PHE A CA  1 
ATOM 382   C C   . PHE A 1 55  ? 4.655   -19.568 -21.185 1.00 66.59  ? 49  PHE A C   1 
ATOM 383   O O   . PHE A 1 55  ? 4.301   -20.726 -20.999 1.00 69.92  ? 49  PHE A O   1 
ATOM 384   C CB  . PHE A 1 55  ? 6.408   -19.393 -22.936 1.00 64.39  ? 49  PHE A CB  1 
ATOM 385   C CG  . PHE A 1 55  ? 6.796   -20.842 -22.666 1.00 73.79  ? 49  PHE A CG  1 
ATOM 386   C CD1 . PHE A 1 55  ? 6.354   -21.872 -23.503 1.00 75.19  ? 49  PHE A CD1 1 
ATOM 387   C CD2 . PHE A 1 55  ? 7.618   -21.166 -21.588 1.00 72.80  ? 49  PHE A CD2 1 
ATOM 388   C CE1 . PHE A 1 55  ? 6.721   -23.188 -23.266 1.00 69.06  ? 49  PHE A CE1 1 
ATOM 389   C CE2 . PHE A 1 55  ? 7.985   -22.483 -21.354 1.00 71.45  ? 49  PHE A CE2 1 
ATOM 390   C CZ  . PHE A 1 55  ? 7.533   -23.488 -22.189 1.00 73.78  ? 49  PHE A CZ  1 
ATOM 391   N N   . ALA A 1 56  ? 4.852   -18.695 -20.192 1.00 71.71  ? 50  ALA A N   1 
ATOM 392   C CA  . ALA A 1 56  ? 4.576   -18.997 -18.795 1.00 71.45  ? 50  ALA A CA  1 
ATOM 393   C C   . ALA A 1 56  ? 3.081   -19.204 -18.569 1.00 73.29  ? 50  ALA A C   1 
ATOM 394   O O   . ALA A 1 56  ? 2.685   -20.087 -17.812 1.00 88.52  ? 50  ALA A O   1 
ATOM 395   C CB  . ALA A 1 56  ? 5.093   -17.873 -17.919 1.00 72.61  ? 50  ALA A CB  1 
ATOM 396   N N   . LYS A 1 57  ? 2.267   -18.358 -19.207 1.00 68.26  ? 51  LYS A N   1 
ATOM 397   C CA  . LYS A 1 57  ? 0.820   -18.470 -19.151 1.00 69.39  ? 51  LYS A CA  1 
ATOM 398   C C   . LYS A 1 57  ? 0.384   -19.853 -19.631 1.00 72.88  ? 51  LYS A C   1 
ATOM 399   O O   . LYS A 1 57  ? -0.493  -20.459 -19.024 1.00 76.62  ? 51  LYS A O   1 
ATOM 400   C CB  . LYS A 1 57  ? 0.161   -17.363 -19.984 1.00 73.37  ? 51  LYS A CB  1 
ATOM 401   C CG  . LYS A 1 57  ? 0.358   -15.951 -19.446 1.00 71.27  ? 51  LYS A CG  1 
ATOM 402   C CD  . LYS A 1 57  ? -0.028  -14.821 -20.394 1.00 70.83  ? 51  LYS A CD  1 
ATOM 403   C CE  . LYS A 1 57  ? 0.291   -13.492 -19.769 1.00 75.01  ? 51  LYS A CE  1 
ATOM 404   N NZ  . LYS A 1 57  ? 0.263   -12.383 -20.723 1.00 79.39  ? 51  LYS A NZ  1 
ATOM 405   N N   . THR A 1 58  ? 1.012   -20.359 -20.703 1.00 78.38  ? 52  THR A N   1 
ATOM 406   C CA  . THR A 1 58  ? 0.615   -21.633 -21.293 1.00 87.16  ? 52  THR A CA  1 
ATOM 407   C C   . THR A 1 58  ? 1.014   -22.790 -20.374 1.00 81.60  ? 52  THR A C   1 
ATOM 408   O O   . THR A 1 58  ? 0.591   -23.921 -20.611 1.00 87.35  ? 52  THR A O   1 
ATOM 409   C CB  . THR A 1 58  ? 1.189   -21.824 -22.707 1.00 93.16  ? 52  THR A CB  1 
ATOM 410   O OG1 . THR A 1 58  ? 2.611   -21.888 -22.650 1.00 89.52  ? 52  THR A OG1 1 
ATOM 411   C CG2 . THR A 1 58  ? 0.786   -20.727 -23.679 1.00 93.18  ? 52  THR A CG2 1 
ATOM 412   N N   . CYS A 1 59  ? 1.841   -22.501 -19.356 1.00 76.82  ? 53  CYS A N   1 
ATOM 413   C CA  . CYS A 1 59  ? 2.277   -23.477 -18.367 1.00 76.66  ? 53  CYS A CA  1 
ATOM 414   C C   . CYS A 1 59  ? 1.456   -23.356 -17.085 1.00 79.09  ? 53  CYS A C   1 
ATOM 415   O O   . CYS A 1 59  ? 1.343   -24.311 -16.320 1.00 74.25  ? 53  CYS A O   1 
ATOM 416   C CB  . CYS A 1 59  ? 3.752   -23.292 -18.040 1.00 77.39  ? 53  CYS A CB  1 
ATOM 417   S SG  . CYS A 1 59  ? 4.799   -23.249 -19.518 1.00 88.80  ? 53  CYS A SG  1 
ATOM 418   N N   . VAL A 1 60  ? 0.912   -22.163 -16.842 1.00 85.53  ? 54  VAL A N   1 
ATOM 419   C CA  . VAL A 1 60  ? -0.097  -21.973 -15.815 1.00 99.13  ? 54  VAL A CA  1 
ATOM 420   C C   . VAL A 1 60  ? -1.370  -22.717 -16.221 1.00 110.32 ? 54  VAL A C   1 
ATOM 421   O O   . VAL A 1 60  ? -2.020  -23.318 -15.369 1.00 127.17 ? 54  VAL A O   1 
ATOM 422   C CB  . VAL A 1 60  ? -0.333  -20.466 -15.576 1.00 106.68 ? 54  VAL A CB  1 
ATOM 423   C CG1 . VAL A 1 60  ? -1.792  -20.107 -15.286 1.00 104.30 ? 54  VAL A CG1 1 
ATOM 424   C CG2 . VAL A 1 60  ? 0.592   -19.930 -14.491 1.00 107.64 ? 54  VAL A CG2 1 
ATOM 425   N N   . ALA A 1 61  ? -1.709  -22.673 -17.521 1.00 107.36 ? 55  ALA A N   1 
ATOM 426   C CA  . ALA A 1 61  ? -2.919  -23.285 -18.056 1.00 96.66  ? 55  ALA A CA  1 
ATOM 427   C C   . ALA A 1 61  ? -2.804  -24.810 -18.054 1.00 99.78  ? 55  ALA A C   1 
ATOM 428   O O   . ALA A 1 61  ? -3.799  -25.510 -17.866 1.00 99.94  ? 55  ALA A O   1 
ATOM 429   C CB  . ALA A 1 61  ? -3.182  -22.760 -19.455 1.00 88.37  ? 55  ALA A CB  1 
ATOM 430   N N   . ASP A 1 62  ? -1.572  -25.251 -18.344 1.00 101.49 ? 56  ASP A N   1 
ATOM 431   C CA  . ASP A 1 62  ? -1.288  -26.698 -18.481 1.00 101.92 ? 56  ASP A CA  1 
ATOM 432   C C   . ASP A 1 62  ? 0.176   -26.994 -18.162 1.00 101.74 ? 56  ASP A C   1 
ATOM 433   O O   . ASP A 1 62  ? 1.033   -26.679 -19.002 1.00 88.84  ? 56  ASP A O   1 
ATOM 434   C CB  . ASP A 1 62  ? -1.573  -27.177 -19.892 1.00 101.94 ? 56  ASP A CB  1 
ATOM 435   C CG  . ASP A 1 62  ? -1.676  -28.685 -20.054 1.00 111.23 ? 56  ASP A CG  1 
ATOM 436   O OD1 . ASP A 1 62  ? -1.882  -29.367 -19.031 1.00 117.65 ? 56  ASP A OD1 1 
ATOM 437   O OD2 . ASP A 1 62  ? -1.548  -29.163 -21.200 1.00 103.65 ? 56  ASP A OD2 1 
ATOM 438   N N   . GLU A 1 63  ? 0.445   -27.627 -17.027 1.00 109.47 ? 57  GLU A N   1 
ATOM 439   C CA  . GLU A 1 63  ? 1.796   -28.094 -16.617 1.00 114.42 ? 57  GLU A CA  1 
ATOM 440   C C   . GLU A 1 63  ? 2.184   -29.124 -17.673 1.00 113.63 ? 57  GLU A C   1 
ATOM 441   O O   . GLU A 1 63  ? 3.390   -29.460 -17.694 1.00 104.81 ? 57  GLU A O   1 
ATOM 442   C CB  . GLU A 1 63  ? 1.782   -28.580 -15.167 1.00 114.33 ? 57  GLU A CB  1 
ATOM 443   C CG  . GLU A 1 63  ? 1.562   -27.459 -14.155 1.00 115.82 ? 57  GLU A CG  1 
ATOM 444   C CD  . GLU A 1 63  ? 2.677   -27.289 -13.139 1.00 121.65 ? 57  GLU A CD  1 
ATOM 445   O OE1 . GLU A 1 63  ? 3.502   -28.215 -13.008 1.00 138.41 ? 57  GLU A OE1 1 
ATOM 446   O OE2 . GLU A 1 63  ? 2.726   -26.232 -12.478 1.00 113.73 ? 57  GLU A OE2 1 
ATOM 447   N N   A SER A 1 64  ? 1.196   -29.883 -18.158 0.42 115.62 ? 58  SER A N   1 
ATOM 448   N N   B SER A 1 64  ? 1.210   -29.897 -18.147 0.58 112.71 ? 58  SER A N   1 
ATOM 449   C CA  A SER A 1 64  ? 1.488   -30.955 -19.145 0.42 114.09 ? 58  SER A CA  1 
ATOM 450   C CA  B SER A 1 64  ? 1.464   -30.969 -19.149 0.58 107.83 ? 58  SER A CA  1 
ATOM 451   C C   A SER A 1 64  ? 2.022   -30.390 -20.468 0.42 111.72 ? 58  SER A C   1 
ATOM 452   C C   B SER A 1 64  ? 2.039   -30.372 -20.438 0.58 107.79 ? 58  SER A C   1 
ATOM 453   O O   A SER A 1 64  ? 3.015   -30.959 -20.966 0.42 110.61 ? 58  SER A O   1 
ATOM 454   O O   B SER A 1 64  ? 2.726   -31.129 -21.152 0.58 105.71 ? 58  SER A O   1 
ATOM 455   C CB  A SER A 1 64  ? 0.270   -31.808 -19.380 0.42 111.46 ? 58  SER A CB  1 
ATOM 456   C CB  B SER A 1 64  ? 0.220   -31.774 -19.412 0.58 100.16 ? 58  SER A CB  1 
ATOM 457   O OG  A SER A 1 64  ? -0.240  -32.306 -18.152 0.42 108.75 ? 58  SER A OG  1 
ATOM 458   O OG  B SER A 1 64  ? -0.376  -31.411 -20.649 0.58 89.02  ? 58  SER A OG  1 
ATOM 459   N N   . ALA A 1 65  ? 1.605   -29.176 -20.841 1.00 111.86 ? 59  ALA A N   1 
ATOM 460   C CA  . ALA A 1 65  ? 2.032   -28.621 -22.153 1.00 107.66 ? 59  ALA A CA  1 
ATOM 461   C C   . ALA A 1 65  ? 3.551   -28.497 -22.222 1.00 117.92 ? 59  ALA A C   1 
ATOM 462   O O   . ALA A 1 65  ? 4.183   -28.062 -21.243 1.00 130.77 ? 59  ALA A O   1 
ATOM 463   C CB  . ALA A 1 65  ? 1.402   -27.274 -22.327 1.00 95.01  ? 59  ALA A CB  1 
ATOM 464   N N   . GLU A 1 66  ? 4.127   -28.812 -23.385 1.00 118.09 ? 60  GLU A N   1 
ATOM 465   C CA  . GLU A 1 66  ? 5.588   -29.048 -23.519 1.00 115.87 ? 60  GLU A CA  1 
ATOM 466   C C   . GLU A 1 66  ? 6.603   -27.953 -23.250 1.00 101.61 ? 60  GLU A C   1 
ATOM 467   O O   . GLU A 1 66  ? 6.370   -26.805 -23.659 1.00 94.32  ? 60  GLU A O   1 
ATOM 468   C CB  . GLU A 1 66  ? 5.918   -29.287 -24.991 1.00 121.70 ? 60  GLU A CB  1 
ATOM 469   C CG  . GLU A 1 66  ? 4.844   -30.073 -25.737 1.00 114.97 ? 60  GLU A CG  1 
ATOM 470   C CD  . GLU A 1 66  ? 4.980   -30.022 -27.248 1.00 112.74 ? 60  GLU A CD  1 
ATOM 471   O OE1 . GLU A 1 66  ? 3.978   -29.712 -27.924 1.00 106.82 ? 60  GLU A OE1 1 
ATOM 472   O OE2 . GLU A 1 66  ? 6.090   -30.296 -27.748 1.00 113.92 ? 60  GLU A OE2 1 
ATOM 473   N N   . ASN A 1 67  ? 7.695   -28.362 -22.608 1.00 98.73  ? 61  ASN A N   1 
ATOM 474   C CA  . ASN A 1 67  ? 8.875   -27.512 -22.318 1.00 94.43  ? 61  ASN A CA  1 
ATOM 475   C C   . ASN A 1 67  ? 8.553   -26.741 -21.045 1.00 90.56  ? 61  ASN A C   1 
ATOM 476   O O   . ASN A 1 67  ? 9.439   -26.058 -20.535 1.00 87.88  ? 61  ASN A O   1 
ATOM 477   C CB  . ASN A 1 67  ? 9.286   -26.728 -23.557 1.00 99.24  ? 61  ASN A CB  1 
ATOM 478   C CG  . ASN A 1 67  ? 9.289   -27.581 -24.802 1.00 104.60 ? 61  ASN A CG  1 
ATOM 479   O OD1 . ASN A 1 67  ? 9.204   -28.810 -24.716 1.00 93.21  ? 61  ASN A OD1 1 
ATOM 480   N ND2 . ASN A 1 67  ? 9.380   -26.953 -25.963 1.00 116.59 ? 61  ASN A ND2 1 
ATOM 481   N N   . CYS A 1 68  ? 7.366   -26.943 -20.496 1.00 89.28  ? 62  CYS A N   1 
ATOM 482   C CA  . CYS A 1 68  ? 7.020   -26.359 -19.176 1.00 90.91  ? 62  CYS A CA  1 
ATOM 483   C C   . CYS A 1 68  ? 7.992   -27.044 -18.196 1.00 91.76  ? 62  CYS A C   1 
ATOM 484   O O   . CYS A 1 68  ? 8.491   -26.368 -17.281 1.00 94.62  ? 62  CYS A O   1 
ATOM 485   C CB  . CYS A 1 68  ? 5.503   -26.312 -19.018 1.00 92.85  ? 62  CYS A CB  1 
ATOM 486   S SG  . CYS A 1 68  ? 4.695   -25.194 -20.202 1.00 99.41  ? 62  CYS A SG  1 
ATOM 487   N N   . ASP A 1 69  ? 8.260   -28.327 -18.407 1.00 86.08  ? 63  ASP A N   1 
ATOM 488   C CA  . ASP A 1 69  ? 9.109   -29.174 -17.525 1.00 87.35  ? 63  ASP A CA  1 
ATOM 489   C C   . ASP A 1 69  ? 10.524  -28.619 -17.480 1.00 88.15  ? 63  ASP A C   1 
ATOM 490   O O   . ASP A 1 69  ? 11.160  -28.743 -16.427 1.00 91.86  ? 63  ASP A O   1 
ATOM 491   C CB  . ASP A 1 69  ? 9.143   -30.624 -17.974 1.00 88.56  ? 63  ASP A CB  1 
ATOM 492   C CG  . ASP A 1 69  ? 9.304   -30.855 -19.467 1.00 91.84  ? 63  ASP A CG  1 
ATOM 493   O OD1 . ASP A 1 69  ? 8.933   -29.953 -20.242 1.00 93.89  ? 63  ASP A OD1 1 
ATOM 494   O OD2 . ASP A 1 69  ? 9.796   -31.938 -19.840 1.00 93.64  ? 63  ASP A OD2 1 
ATOM 495   N N   . LYS A 1 70  ? 11.035  -28.102 -18.582 1.00 81.63  ? 64  LYS A N   1 
ATOM 496   C CA  . LYS A 1 70  ? 12.466  -27.744 -18.663 1.00 79.02  ? 64  LYS A CA  1 
ATOM 497   C C   . LYS A 1 70  ? 12.840  -26.660 -17.665 1.00 77.56  ? 64  LYS A C   1 
ATOM 498   O O   . LYS A 1 70  ? 11.972  -25.856 -17.294 1.00 66.82  ? 64  LYS A O   1 
ATOM 499   C CB  . LYS A 1 70  ? 12.802  -27.101 -20.008 1.00 84.59  ? 64  LYS A CB  1 
ATOM 500   C CG  . LYS A 1 70  ? 12.530  -27.922 -21.254 1.00 92.16  ? 64  LYS A CG  1 
ATOM 501   C CD  . LYS A 1 70  ? 13.033  -27.207 -22.501 1.00 94.99  ? 64  LYS A CD  1 
ATOM 502   C CE  . LYS A 1 70  ? 12.819  -27.994 -23.751 1.00 95.71  ? 64  LYS A CE  1 
ATOM 503   N NZ  . LYS A 1 70  ? 11.910  -29.120 -23.534 1.00 92.93  ? 64  LYS A NZ  1 
ATOM 504   N N   . SER A 1 71  ? 14.062  -26.743 -17.161 1.00 74.20  ? 65  SER A N   1 
ATOM 505   C CA  . SER A 1 71  ? 14.579  -25.824 -16.128 1.00 71.70  ? 65  SER A CA  1 
ATOM 506   C C   . SER A 1 71  ? 14.693  -24.401 -16.657 1.00 77.79  ? 65  SER A C   1 
ATOM 507   O O   . SER A 1 71  ? 14.951  -24.231 -17.855 1.00 82.45  ? 65  SER A O   1 
ATOM 508   C CB  . SER A 1 71  ? 15.917  -26.281 -15.715 1.00 79.95  ? 65  SER A CB  1 
ATOM 509   O OG  . SER A 1 71  ? 16.871  -26.014 -16.732 1.00 84.03  ? 65  SER A OG  1 
ATOM 510   N N   . LEU A 1 72  ? 14.533  -23.420 -15.777 1.00 81.63  ? 66  LEU A N   1 
ATOM 511   C CA  . LEU A 1 72  ? 14.492  -21.997 -16.174 1.00 72.88  ? 66  LEU A CA  1 
ATOM 512   C C   . LEU A 1 72  ? 15.821  -21.647 -16.814 1.00 66.62  ? 66  LEU A C   1 
ATOM 513   O O   . LEU A 1 72  ? 15.813  -20.947 -17.829 1.00 60.96  ? 66  LEU A O   1 
ATOM 514   C CB  . LEU A 1 72  ? 14.280  -21.202 -14.894 1.00 74.55  ? 66  LEU A CB  1 
ATOM 515   C CG  . LEU A 1 72  ? 13.052  -21.558 -14.051 1.00 85.11  ? 66  LEU A CG  1 
ATOM 516   C CD1 . LEU A 1 72  ? 13.242  -21.047 -12.637 1.00 87.69  ? 66  LEU A CD1 1 
ATOM 517   C CD2 . LEU A 1 72  ? 11.807  -20.947 -14.646 1.00 82.53  ? 66  LEU A CD2 1 
ATOM 518   N N   . HIS A 1 73  ? 16.906  -22.167 -16.275 1.00 65.54  ? 67  HIS A N   1 
ATOM 519   C CA  . HIS A 1 73  ? 18.227  -21.768 -16.800 1.00 68.38  ? 67  HIS A CA  1 
ATOM 520   C C   . HIS A 1 73  ? 18.209  -22.222 -18.253 1.00 72.94  ? 67  HIS A C   1 
ATOM 521   O O   . HIS A 1 73  ? 18.746  -21.510 -19.112 1.00 74.26  ? 67  HIS A O   1 
ATOM 522   C CB  . HIS A 1 73  ? 19.328  -22.368 -15.930 1.00 66.37  ? 67  HIS A CB  1 
ATOM 523   C CG  . HIS A 1 73  ? 19.667  -21.525 -14.752 1.00 70.24  ? 67  HIS A CG  1 
ATOM 524   N ND1 . HIS A 1 73  ? 19.850  -20.164 -14.849 1.00 72.39  ? 67  HIS A ND1 1 
ATOM 525   C CD2 . HIS A 1 73  ? 19.846  -21.832 -13.468 1.00 77.40  ? 67  HIS A CD2 1 
ATOM 526   C CE1 . HIS A 1 73  ? 20.130  -19.678 -13.652 1.00 81.33  ? 67  HIS A CE1 1 
ATOM 527   N NE2 . HIS A 1 73  ? 20.135  -20.675 -12.798 1.00 82.39  ? 67  HIS A NE2 1 
ATOM 528   N N   . THR A 1 74  ? 17.643  -23.390 -18.521 1.00 80.41  ? 68  THR A N   1 
ATOM 529   C CA  . THR A 1 74  ? 17.482  -23.813 -19.928 1.00 88.43  ? 68  THR A CA  1 
ATOM 530   C C   . THR A 1 74  ? 16.546  -22.862 -20.644 1.00 81.21  ? 68  THR A C   1 
ATOM 531   O O   . THR A 1 74  ? 16.962  -22.296 -21.664 1.00 78.70  ? 68  THR A O   1 
ATOM 532   C CB  . THR A 1 74  ? 16.969  -25.249 -19.975 1.00 87.79  ? 68  THR A CB  1 
ATOM 533   O OG1 . THR A 1 74  ? 17.993  -26.013 -19.347 1.00 88.20  ? 68  THR A OG1 1 
ATOM 534   C CG2 . THR A 1 74  ? 16.742  -25.747 -21.389 1.00 82.36  ? 68  THR A CG2 1 
ATOM 535   N N   . LEU A 1 75  ? 15.338  -22.656 -20.127 1.00 72.33  ? 69  LEU A N   1 
ATOM 536   C CA  . LEU A 1 75  ? 14.362  -21.846 -20.844 1.00 72.70  ? 69  LEU A CA  1 
ATOM 537   C C   . LEU A 1 75  ? 14.877  -20.437 -21.131 1.00 75.43  ? 69  LEU A C   1 
ATOM 538   O O   . LEU A 1 75  ? 14.643  -19.918 -22.213 1.00 73.42  ? 69  LEU A O   1 
ATOM 539   C CB  . LEU A 1 75  ? 13.075  -21.755 -20.033 1.00 73.55  ? 69  LEU A CB  1 
ATOM 540   C CG  . LEU A 1 75  ? 12.249  -23.035 -19.950 1.00 76.64  ? 69  LEU A CG  1 
ATOM 541   C CD1 . LEU A 1 75  ? 11.035  -22.820 -19.068 1.00 75.27  ? 69  LEU A CD1 1 
ATOM 542   C CD2 . LEU A 1 75  ? 11.840  -23.473 -21.341 1.00 82.76  ? 69  LEU A CD2 1 
ATOM 543   N N   . PHE A 1 76  ? 15.488  -19.795 -20.130 1.00 76.62  ? 70  PHE A N   1 
ATOM 544   C CA  . PHE A 1 76  ? 16.019  -18.449 -20.275 1.00 76.64  ? 70  PHE A CA  1 
ATOM 545   C C   . PHE A 1 76  ? 17.276  -18.509 -21.130 1.00 78.25  ? 70  PHE A C   1 
ATOM 546   O O   . PHE A 1 76  ? 17.462  -17.689 -22.030 1.00 74.73  ? 70  PHE A O   1 
ATOM 547   C CB  . PHE A 1 76  ? 16.316  -17.840 -18.901 1.00 75.29  ? 70  PHE A CB  1 
ATOM 548   C CG  . PHE A 1 76  ? 15.084  -17.518 -18.065 1.00 76.37  ? 70  PHE A CG  1 
ATOM 549   C CD1 . PHE A 1 76  ? 13.823  -18.020 -18.394 1.00 77.35  ? 70  PHE A CD1 1 
ATOM 550   C CD2 . PHE A 1 76  ? 15.197  -16.719 -16.934 1.00 81.58  ? 70  PHE A CD2 1 
ATOM 551   C CE1 . PHE A 1 76  ? 12.712  -17.717 -17.622 1.00 78.66  ? 70  PHE A CE1 1 
ATOM 552   C CE2 . PHE A 1 76  ? 14.086  -16.423 -16.159 1.00 86.43  ? 70  PHE A CE2 1 
ATOM 553   C CZ  . PHE A 1 76  ? 12.845  -16.918 -16.507 1.00 86.51  ? 70  PHE A CZ  1 
ATOM 554   N N   . GLY A 1 77  ? 18.126  -19.491 -20.812 1.00 82.33  ? 71  GLY A N   1 
ATOM 555   C CA  . GLY A 1 77  ? 19.305  -19.792 -21.602 1.00 90.44  ? 71  GLY A CA  1 
ATOM 556   C C   . GLY A 1 77  ? 18.960  -19.991 -23.078 1.00 93.93  ? 71  GLY A C   1 
ATOM 557   O O   . GLY A 1 77  ? 19.695  -19.517 -23.944 1.00 91.71  ? 71  GLY A O   1 
ATOM 558   N N   . ASP A 1 78  ? 17.856  -20.686 -23.338 1.00 92.74  ? 72  ASP A N   1 
ATOM 559   C CA  . ASP A 1 78  ? 17.389  -20.877 -24.733 1.00 88.18  ? 72  ASP A CA  1 
ATOM 560   C C   . ASP A 1 78  ? 17.173  -19.510 -25.377 1.00 77.99  ? 72  ASP A C   1 
ATOM 561   O O   . ASP A 1 78  ? 17.823  -19.233 -26.385 1.00 76.19  ? 72  ASP A O   1 
ATOM 562   C CB  . ASP A 1 78  ? 16.075  -21.640 -24.760 1.00 87.75  ? 72  ASP A CB  1 
ATOM 563   C CG  . ASP A 1 78  ? 16.135  -23.159 -24.753 1.00 85.86  ? 72  ASP A CG  1 
ATOM 564   O OD1 . ASP A 1 78  ? 17.017  -23.710 -24.081 1.00 72.70  ? 72  ASP A OD1 1 
ATOM 565   O OD2 . ASP A 1 78  ? 15.270  -23.778 -25.402 1.00 83.02  ? 72  ASP A OD2 1 
ATOM 566   N N   . LYS A 1 79  ? 16.381  -18.625 -24.775 1.00 73.27  ? 73  LYS A N   1 
ATOM 567   C CA  . LYS A 1 79  ? 16.010  -17.337 -25.422 1.00 63.20  ? 73  LYS A CA  1 
ATOM 568   C C   . LYS A 1 79  ? 17.202  -16.390 -25.566 1.00 59.99  ? 73  LYS A C   1 
ATOM 569   O O   . LYS A 1 79  ? 17.196  -15.612 -26.517 1.00 53.32  ? 73  LYS A O   1 
ATOM 570   C CB  . LYS A 1 79  ? 14.885  -16.651 -24.644 1.00 64.49  ? 73  LYS A CB  1 
ATOM 571   C CG  . LYS A 1 79  ? 13.984  -15.728 -25.436 1.00 65.41  ? 73  LYS A CG  1 
ATOM 572   C CD  . LYS A 1 79  ? 13.268  -16.441 -26.572 1.00 69.48  ? 73  LYS A CD  1 
ATOM 573   C CE  . LYS A 1 79  ? 12.014  -17.101 -26.116 1.00 75.94  ? 73  LYS A CE  1 
ATOM 574   N NZ  . LYS A 1 79  ? 11.333  -17.745 -27.240 1.00 81.73  ? 73  LYS A NZ  1 
ATOM 575   N N   . LEU A 1 80  ? 18.153  -16.407 -24.643 1.00 61.81  ? 74  LEU A N   1 
ATOM 576   C CA  . LEU A 1 80  ? 19.348  -15.550 -24.843 1.00 70.16  ? 74  LEU A CA  1 
ATOM 577   C C   . LEU A 1 80  ? 20.063  -16.031 -26.099 1.00 76.18  ? 74  LEU A C   1 
ATOM 578   O O   . LEU A 1 80  ? 20.563  -15.196 -26.859 1.00 84.44  ? 74  LEU A O   1 
ATOM 579   C CB  . LEU A 1 80  ? 20.247  -15.612 -23.615 1.00 69.41  ? 74  LEU A CB  1 
ATOM 580   C CG  . LEU A 1 80  ? 19.604  -15.133 -22.314 1.00 76.55  ? 74  LEU A CG  1 
ATOM 581   C CD1 . LEU A 1 80  ? 20.640  -14.943 -21.230 1.00 72.68  ? 74  LEU A CD1 1 
ATOM 582   C CD2 . LEU A 1 80  ? 18.877  -13.835 -22.592 1.00 86.09  ? 74  LEU A CD2 1 
ATOM 583   N N   . CYS A 1 81  ? 20.084  -17.335 -26.315 1.00 88.49  ? 75  CYS A N   1 
ATOM 584   C CA  . CYS A 1 81  ? 20.852  -17.861 -27.467 1.00 93.78  ? 75  CYS A CA  1 
ATOM 585   C C   . CYS A 1 81  ? 20.073  -17.504 -28.729 1.00 91.68  ? 75  CYS A C   1 
ATOM 586   O O   . CYS A 1 81  ? 20.712  -17.361 -29.780 1.00 99.23  ? 75  CYS A O   1 
ATOM 587   C CB  . CYS A 1 81  ? 21.210  -19.310 -27.196 1.00 102.38 ? 75  CYS A CB  1 
ATOM 588   S SG  . CYS A 1 81  ? 22.240  -19.447 -25.714 1.00 122.80 ? 75  CYS A SG  1 
ATOM 589   N N   . THR A 1 82  ? 18.750  -17.385 -28.633 1.00 90.01  ? 76  THR A N   1 
ATOM 590   C CA  . THR A 1 82  ? 18.015  -16.832 -29.775 1.00 87.03  ? 76  THR A CA  1 
ATOM 591   C C   . THR A 1 82  ? 18.569  -15.441 -29.816 1.00 79.11  ? 76  THR A C   1 
ATOM 592   O O   . THR A 1 82  ? 18.703  -14.895 -28.719 1.00 73.24  ? 76  THR A O   1 
ATOM 593   C CB  . THR A 1 82  ? 16.542  -16.833 -29.420 1.00 98.33  ? 76  THR A CB  1 
ATOM 594   O OG1 . THR A 1 82  ? 16.113  -18.146 -29.762 1.00 115.88 ? 76  THR A OG1 1 
ATOM 595   C CG2 . THR A 1 82  ? 15.762  -15.779 -30.183 1.00 97.58  ? 76  THR A CG2 1 
ATOM 596   N N   . VAL A 1 83  ? 18.850  -14.858 -30.977 1.00 90.32  ? 77  VAL A N   1 
ATOM 597   C CA  . VAL A 1 83  ? 19.563  -13.544 -31.034 1.00 106.38 ? 77  VAL A CA  1 
ATOM 598   C C   . VAL A 1 83  ? 21.071  -13.829 -30.980 1.00 108.63 ? 77  VAL A C   1 
ATOM 599   O O   . VAL A 1 83  ? 21.629  -13.761 -29.871 1.00 124.00 ? 77  VAL A O   1 
ATOM 600   C CB  . VAL A 1 83  ? 19.193  -12.511 -29.954 1.00 121.92 ? 77  VAL A CB  1 
ATOM 601   C CG1 . VAL A 1 83  ? 20.025  -11.240 -30.064 1.00 129.27 ? 77  VAL A CG1 1 
ATOM 602   C CG2 . VAL A 1 83  ? 17.707  -12.174 -29.985 1.00 116.30 ? 77  VAL A CG2 1 
ATOM 603   N N   . THR A 1 85  ? 23.361  -14.155 -32.515 1.00 152.73 ? 79  THR A N   1 
ATOM 604   C CA  . THR A 1 85  ? 24.310  -13.313 -33.251 1.00 134.96 ? 79  THR A CA  1 
ATOM 605   C C   . THR A 1 85  ? 25.056  -12.443 -32.266 1.00 142.44 ? 79  THR A C   1 
ATOM 606   O O   . THR A 1 85  ? 24.442  -11.476 -31.782 1.00 141.97 ? 79  THR A O   1 
ATOM 607   C CB  . THR A 1 85  ? 23.450  -12.496 -34.204 1.00 120.00 ? 79  THR A CB  1 
ATOM 608   O OG1 . THR A 1 85  ? 22.728  -11.576 -33.393 1.00 118.60 ? 79  THR A OG1 1 
ATOM 609   C CG2 . THR A 1 85  ? 22.448  -13.356 -34.950 1.00 110.35 ? 79  THR A CG2 1 
ATOM 610   N N   . LEU A 1 86  ? 26.327  -12.743 -31.944 1.00 154.51 ? 80  LEU A N   1 
ATOM 611   C CA  . LEU A 1 86  ? 26.962  -11.799 -31.008 1.00 164.78 ? 80  LEU A CA  1 
ATOM 612   C C   . LEU A 1 86  ? 28.270  -11.218 -31.552 1.00 150.84 ? 80  LEU A C   1 
ATOM 613   O O   . LEU A 1 86  ? 29.335  -11.659 -31.078 1.00 136.62 ? 80  LEU A O   1 
ATOM 614   C CB  . LEU A 1 86  ? 27.146  -12.650 -29.762 1.00 189.24 ? 80  LEU A CB  1 
ATOM 615   C CG  . LEU A 1 86  ? 26.010  -12.534 -28.742 1.00 205.18 ? 80  LEU A CG  1 
ATOM 616   C CD1 . LEU A 1 86  ? 26.065  -13.616 -27.680 1.00 216.48 ? 80  LEU A CD1 1 
ATOM 617   C CD2 . LEU A 1 86  ? 25.989  -11.148 -28.115 1.00 203.57 ? 80  LEU A CD2 1 
ATOM 618   N N   . ARG A 1 87  ? 28.222  -10.355 -32.560 1.00 146.97 ? 81  ARG A N   1 
ATOM 619   C CA  . ARG A 1 87  ? 29.460  -9.643  -32.963 1.00 162.90 ? 81  ARG A CA  1 
ATOM 620   C C   . ARG A 1 87  ? 29.863  -8.770  -31.779 1.00 178.60 ? 81  ARG A C   1 
ATOM 621   O O   . ARG A 1 87  ? 31.067  -8.678  -31.482 1.00 193.99 ? 81  ARG A O   1 
ATOM 622   C CB  . ARG A 1 87  ? 29.258  -8.770  -34.204 1.00 150.44 ? 81  ARG A CB  1 
ATOM 623   C CG  . ARG A 1 87  ? 28.467  -9.443  -35.316 1.00 140.26 ? 81  ARG A CG  1 
ATOM 624   C CD  . ARG A 1 87  ? 29.024  -10.808 -35.690 1.00 138.68 ? 81  ARG A CD  1 
ATOM 625   N NE  . ARG A 1 87  ? 28.158  -11.503 -36.648 1.00 132.73 ? 81  ARG A NE  1 
ATOM 626   C CZ  . ARG A 1 87  ? 27.339  -12.500 -36.342 1.00 129.82 ? 81  ARG A CZ  1 
ATOM 627   N NH1 . ARG A 1 87  ? 27.476  -13.137 -35.193 1.00 127.10 ? 81  ARG A NH1 1 
ATOM 628   N NH2 . ARG A 1 87  ? 26.389  -12.858 -37.187 1.00 135.29 ? 81  ARG A NH2 1 
ATOM 629   N N   . GLU A 1 88  ? 28.866  -8.152  -31.144 1.00 164.39 ? 82  GLU A N   1 
ATOM 630   C CA  . GLU A 1 88  ? 29.123  -7.188  -30.048 1.00 145.39 ? 82  GLU A CA  1 
ATOM 631   C C   . GLU A 1 88  ? 29.806  -7.838  -28.835 1.00 137.94 ? 82  GLU A C   1 
ATOM 632   O O   . GLU A 1 88  ? 30.693  -7.173  -28.266 1.00 117.97 ? 82  GLU A O   1 
ATOM 633   C CB  . GLU A 1 88  ? 27.781  -6.554  -29.693 1.00 144.77 ? 82  GLU A CB  1 
ATOM 634   C CG  . GLU A 1 88  ? 27.545  -5.221  -30.395 1.00 147.35 ? 82  GLU A CG  1 
ATOM 635   C CD  . GLU A 1 88  ? 27.420  -5.336  -31.902 1.00 149.88 ? 82  GLU A CD  1 
ATOM 636   O OE1 . GLU A 1 88  ? 26.493  -6.036  -32.364 1.00 168.14 ? 82  GLU A OE1 1 
ATOM 637   O OE2 . GLU A 1 88  ? 28.248  -4.725  -32.611 1.00 129.85 ? 82  GLU A OE2 1 
ATOM 638   N N   . MET A 1 93  ? 31.878  -14.151 -25.351 1.00 136.34 ? 87  MET A N   1 
ATOM 639   C CA  . MET A 1 93  ? 30.613  -14.303 -24.586 1.00 145.35 ? 87  MET A CA  1 
ATOM 640   C C   . MET A 1 93  ? 29.628  -15.089 -25.454 1.00 149.44 ? 87  MET A C   1 
ATOM 641   O O   . MET A 1 93  ? 28.736  -15.752 -24.900 1.00 165.70 ? 87  MET A O   1 
ATOM 642   C CB  . MET A 1 93  ? 30.022  -12.935 -24.234 1.00 147.12 ? 87  MET A CB  1 
ATOM 643   C CG  . MET A 1 93  ? 28.645  -12.677 -24.826 1.00 149.04 ? 87  MET A CG  1 
ATOM 644   S SD  . MET A 1 93  ? 27.321  -12.377 -23.636 1.00 145.12 ? 87  MET A SD  1 
ATOM 645   C CE  . MET A 1 93  ? 28.158  -12.741 -22.087 1.00 121.79 ? 87  MET A CE  1 
ATOM 646   N N   . ALA A 1 94  ? 29.813  -15.036 -26.766 1.00 146.71 ? 88  ALA A N   1 
ATOM 647   C CA  . ALA A 1 94  ? 28.943  -15.755 -27.724 1.00 150.70 ? 88  ALA A CA  1 
ATOM 648   C C   . ALA A 1 94  ? 29.057  -17.252 -27.496 1.00 135.37 ? 88  ALA A C   1 
ATOM 649   O O   . ALA A 1 94  ? 28.044  -17.969 -27.606 1.00 124.83 ? 88  ALA A O   1 
ATOM 650   C CB  . ALA A 1 94  ? 29.343  -15.403 -29.128 1.00 164.10 ? 88  ALA A CB  1 
ATOM 651   N N   . ASP A 1 95  ? 30.267  -17.716 -27.213 1.00 119.36 ? 89  ASP A N   1 
ATOM 652   C CA  . ASP A 1 95  ? 30.464  -19.178 -27.151 1.00 113.01 ? 89  ASP A CA  1 
ATOM 653   C C   . ASP A 1 95  ? 29.604  -19.784 -26.048 1.00 108.70 ? 89  ASP A C   1 
ATOM 654   O O   . ASP A 1 95  ? 28.966  -20.815 -26.320 1.00 117.10 ? 89  ASP A O   1 
ATOM 655   C CB  . ASP A 1 95  ? 31.924  -19.461 -26.875 1.00 111.51 ? 89  ASP A CB  1 
ATOM 656   C CG  . ASP A 1 95  ? 32.764  -18.243 -26.522 1.00 117.35 ? 89  ASP A CG  1 
ATOM 657   O OD1 . ASP A 1 95  ? 32.203  -17.291 -25.939 1.00 116.05 ? 89  ASP A OD1 1 
ATOM 658   O OD2 . ASP A 1 95  ? 33.973  -18.260 -26.831 1.00 122.37 ? 89  ASP A OD2 1 
ATOM 659   N N   . CYS A 1 96  ? 29.505  -19.147 -24.886 1.00 100.21 ? 90  CYS A N   1 
ATOM 660   C CA  . CYS A 1 96  ? 28.599  -19.764 -23.903 1.00 97.69  ? 90  CYS A CA  1 
ATOM 661   C C   . CYS A 1 96  ? 27.275  -19.977 -24.621 1.00 95.06  ? 90  CYS A C   1 
ATOM 662   O O   . CYS A 1 96  ? 26.716  -21.081 -24.554 1.00 83.47  ? 90  CYS A O   1 
ATOM 663   C CB  . CYS A 1 96  ? 28.080  -18.823 -22.829 1.00 94.13  ? 90  CYS A CB  1 
ATOM 664   S SG  . CYS A 1 96  ? 29.186  -17.580 -22.120 1.00 86.58  ? 90  CYS A SG  1 
ATOM 665   N N   . CYS A 1 97  ? 26.827  -18.961 -25.341 1.00 108.38 ? 91  CYS A N   1 
ATOM 666   C CA  . CYS A 1 97  ? 25.456  -18.997 -25.928 1.00 123.24 ? 91  CYS A CA  1 
ATOM 667   C C   . CYS A 1 97  ? 25.171  -20.190 -26.825 1.00 134.02 ? 91  CYS A C   1 
ATOM 668   O O   . CYS A 1 97  ? 24.006  -20.484 -27.069 1.00 147.42 ? 91  CYS A O   1 
ATOM 669   C CB  . CYS A 1 97  ? 24.830  -17.715 -26.440 1.00 125.25 ? 91  CYS A CB  1 
ATOM 670   S SG  . CYS A 1 97  ? 23.222  -17.658 -25.599 1.00 144.66 ? 91  CYS A SG  1 
ATOM 671   N N   . ALA A 1 98  ? 26.225  -20.739 -27.401 1.00 132.97 ? 92  ALA A N   1 
ATOM 672   C CA  . ALA A 1 98  ? 25.962  -21.922 -28.221 1.00 134.68 ? 92  ALA A CA  1 
ATOM 673   C C   . ALA A 1 98  ? 24.928  -22.720 -27.449 1.00 136.42 ? 92  ALA A C   1 
ATOM 674   O O   . ALA A 1 98  ? 23.890  -23.111 -28.019 1.00 140.76 ? 92  ALA A O   1 
ATOM 675   C CB  . ALA A 1 98  ? 27.234  -22.697 -28.380 1.00 134.10 ? 92  ALA A CB  1 
ATOM 676   N N   . LYS A 1 99  ? 25.208  -22.930 -26.164 1.00 142.30 ? 93  LYS A N   1 
ATOM 677   C CA  . LYS A 1 99  ? 24.308  -23.750 -25.319 1.00 157.07 ? 93  LYS A CA  1 
ATOM 678   C C   . LYS A 1 99  ? 24.034  -23.000 -24.021 1.00 182.42 ? 93  LYS A C   1 
ATOM 679   O O   . LYS A 1 99  ? 25.000  -22.510 -23.412 1.00 231.55 ? 93  LYS A O   1 
ATOM 680   C CB  . LYS A 1 99  ? 25.014  -25.036 -24.880 1.00 133.58 ? 93  LYS A CB  1 
ATOM 681   C CG  . LYS A 1 99  ? 26.527  -25.037 -25.019 1.00 106.50 ? 93  LYS A CG  1 
ATOM 682   C CD  . LYS A 1 99  ? 27.256  -24.886 -23.692 1.00 89.57  ? 93  LYS A CD  1 
ATOM 683   C CE  . LYS A 1 99  ? 28.488  -24.068 -23.872 1.00 77.18  ? 93  LYS A CE  1 
ATOM 684   N NZ  . LYS A 1 99  ? 28.689  -23.787 -25.295 1.00 70.31  ? 93  LYS A NZ  1 
ATOM 685   N N   . GLN A 1 100 ? 22.793  -22.997 -23.535 1.00 169.29 ? 94  GLN A N   1 
ATOM 686   C CA  . GLN A 1 100 ? 22.648  -22.327 -22.233 1.00 145.82 ? 94  GLN A CA  1 
ATOM 687   C C   . GLN A 1 100 ? 23.538  -23.210 -21.379 1.00 157.16 ? 94  GLN A C   1 
ATOM 688   O O   . GLN A 1 100 ? 23.439  -24.447 -21.525 1.00 155.87 ? 94  GLN A O   1 
ATOM 689   C CB  . GLN A 1 100 ? 21.180  -22.540 -21.919 1.00 140.97 ? 94  GLN A CB  1 
ATOM 690   C CG  . GLN A 1 100 ? 20.329  -22.791 -23.162 1.00 138.24 ? 94  GLN A CG  1 
ATOM 691   C CD  . GLN A 1 100 ? 20.200  -24.243 -23.571 1.00 137.01 ? 94  GLN A CD  1 
ATOM 692   O OE1 . GLN A 1 100 ? 20.794  -25.145 -22.971 1.00 135.08 ? 94  GLN A OE1 1 
ATOM 693   N NE2 . GLN A 1 100 ? 19.426  -24.481 -24.619 1.00 141.02 ? 94  GLN A NE2 1 
ATOM 694   N N   . GLU A 1 101 ? 24.359  -22.644 -20.496 1.00 173.34 ? 95  GLU A N   1 
ATOM 695   C CA  . GLU A 1 101 ? 25.275  -23.600 -19.815 1.00 169.34 ? 95  GLU A CA  1 
ATOM 696   C C   . GLU A 1 101 ? 24.370  -24.543 -18.993 1.00 148.76 ? 95  GLU A C   1 
ATOM 697   O O   . GLU A 1 101 ? 23.391  -24.053 -18.387 1.00 156.23 ? 95  GLU A O   1 
ATOM 698   C CB  . GLU A 1 101 ? 26.435  -22.902 -19.097 1.00 174.26 ? 95  GLU A CB  1 
ATOM 699   C CG  . GLU A 1 101 ? 27.241  -21.985 -20.006 1.00 169.75 ? 95  GLU A CG  1 
ATOM 700   C CD  . GLU A 1 101 ? 26.610  -20.612 -20.066 1.00 159.26 ? 95  GLU A CD  1 
ATOM 701   O OE1 . GLU A 1 101 ? 27.105  -19.702 -19.374 1.00 136.69 ? 95  GLU A OE1 1 
ATOM 702   O OE2 . GLU A 1 101 ? 25.609  -20.465 -20.793 1.00 161.55 ? 95  GLU A OE2 1 
ATOM 703   N N   . PRO A 1 102 ? 24.646  -25.862 -18.948 1.00 120.64 ? 96  PRO A N   1 
ATOM 704   C CA  . PRO A 1 102 ? 23.864  -26.781 -18.147 1.00 110.70 ? 96  PRO A CA  1 
ATOM 705   C C   . PRO A 1 102 ? 24.704  -27.377 -17.031 1.00 109.28 ? 96  PRO A C   1 
ATOM 706   O O   . PRO A 1 102 ? 25.363  -26.610 -16.305 1.00 83.33  ? 96  PRO A O   1 
ATOM 707   C CB  . PRO A 1 102 ? 23.551  -27.773 -19.258 1.00 104.90 ? 96  PRO A CB  1 
ATOM 708   C CG  . PRO A 1 102 ? 24.779  -27.746 -20.154 1.00 106.59 ? 96  PRO A CG  1 
ATOM 709   C CD  . PRO A 1 102 ? 25.623  -26.546 -19.755 1.00 108.46 ? 96  PRO A CD  1 
ATOM 710   N N   . ASN A 1 105 ? 26.214  -20.972 -17.095 1.00 87.64  ? 99  ASN A N   1 
ATOM 711   C CA  . ASN A 1 105 ? 26.051  -19.617 -16.513 1.00 81.57  ? 99  ASN A CA  1 
ATOM 712   C C   . ASN A 1 105 ? 27.417  -19.112 -16.064 1.00 91.00  ? 99  ASN A C   1 
ATOM 713   O O   . ASN A 1 105 ? 27.723  -17.953 -16.344 1.00 107.61 ? 99  ASN A O   1 
ATOM 714   C CB  . ASN A 1 105 ? 25.083  -19.598 -15.339 1.00 76.62  ? 99  ASN A CB  1 
ATOM 715   C CG  . ASN A 1 105 ? 23.637  -19.740 -15.735 1.00 71.26  ? 99  ASN A CG  1 
ATOM 716   O OD1 . ASN A 1 105 ? 23.247  -19.357 -16.842 1.00 72.10  ? 99  ASN A OD1 1 
ATOM 717   N ND2 . ASN A 1 105 ? 22.830  -20.276 -14.835 1.00 67.09  ? 99  ASN A ND2 1 
ATOM 718   N N   . GLU A 1 106 ? 28.186  -19.934 -15.356 1.00 97.23  ? 100 GLU A N   1 
ATOM 719   C CA  . GLU A 1 106 ? 29.503  -19.539 -14.861 1.00 106.09 ? 100 GLU A CA  1 
ATOM 720   C C   . GLU A 1 106 ? 30.324  -18.902 -15.981 1.00 107.51 ? 100 GLU A C   1 
ATOM 721   O O   . GLU A 1 106 ? 31.282  -18.184 -15.700 1.00 91.72  ? 100 GLU A O   1 
ATOM 722   C CB  . GLU A 1 106 ? 30.335  -20.642 -14.202 1.00 114.37 ? 100 GLU A CB  1 
ATOM 723   C CG  . GLU A 1 106 ? 30.491  -21.917 -15.027 1.00 121.34 ? 100 GLU A CG  1 
ATOM 724   C CD  . GLU A 1 106 ? 29.543  -23.025 -14.606 1.00 121.18 ? 100 GLU A CD  1 
ATOM 725   O OE1 . GLU A 1 106 ? 28.311  -22.822 -14.672 1.00 120.16 ? 100 GLU A OE1 1 
ATOM 726   O OE2 . GLU A 1 106 ? 30.053  -24.087 -14.189 1.00 118.38 ? 100 GLU A OE2 1 
ATOM 727   N N   . CYS A 1 107 ? 29.938  -19.195 -17.232 1.00 117.68 ? 101 CYS A N   1 
ATOM 728   C CA  . CYS A 1 107 ? 30.459  -18.532 -18.418 1.00 121.20 ? 101 CYS A CA  1 
ATOM 729   C C   . CYS A 1 107 ? 29.830  -17.150 -18.614 1.00 117.87 ? 101 CYS A C   1 
ATOM 730   O O   . CYS A 1 107 ? 30.522  -16.210 -18.996 1.00 126.34 ? 101 CYS A O   1 
ATOM 731   C CB  . CYS A 1 107 ? 30.222  -19.399 -19.647 1.00 123.06 ? 101 CYS A CB  1 
ATOM 732   S SG  . CYS A 1 107 ? 30.681  -18.585 -21.198 1.00 128.98 ? 101 CYS A SG  1 
ATOM 733   N N   . PHE A 1 108 ? 28.515  -17.040 -18.394 1.00 109.51 ? 102 PHE A N   1 
ATOM 734   C CA  . PHE A 1 108 ? 27.835  -15.754 -18.412 1.00 109.45 ? 102 PHE A CA  1 
ATOM 735   C C   . PHE A 1 108 ? 28.343  -14.827 -17.301 1.00 116.77 ? 102 PHE A C   1 
ATOM 736   O O   . PHE A 1 108 ? 28.508  -13.629 -17.532 1.00 119.92 ? 102 PHE A O   1 
ATOM 737   C CB  . PHE A 1 108 ? 26.324  -15.974 -18.305 1.00 102.27 ? 102 PHE A CB  1 
ATOM 738   C CG  . PHE A 1 108 ? 25.573  -16.141 -19.617 1.00 102.28 ? 102 PHE A CG  1 
ATOM 739   C CD1 . PHE A 1 108 ? 25.997  -15.516 -20.786 1.00 110.54 ? 102 PHE A CD1 1 
ATOM 740   C CD2 . PHE A 1 108 ? 24.397  -16.876 -19.656 1.00 97.06  ? 102 PHE A CD2 1 
ATOM 741   C CE1 . PHE A 1 108 ? 25.277  -15.644 -21.961 1.00 112.44 ? 102 PHE A CE1 1 
ATOM 742   C CE2 . PHE A 1 108 ? 23.683  -16.999 -20.833 1.00 102.87 ? 102 PHE A CE2 1 
ATOM 743   C CZ  . PHE A 1 108 ? 24.125  -16.388 -21.982 1.00 108.54 ? 102 PHE A CZ  1 
ATOM 744   N N   . LEU A 1 109 ? 28.581  -15.374 -16.100 1.00 113.19 ? 103 LEU A N   1 
ATOM 745   C CA  . LEU A 1 109 ? 29.067  -14.588 -14.973 1.00 107.36 ? 103 LEU A CA  1 
ATOM 746   C C   . LEU A 1 109 ? 30.585  -14.756 -14.911 1.00 111.61 ? 103 LEU A C   1 
ATOM 747   O O   . LEU A 1 109 ? 31.090  -15.832 -15.213 1.00 102.81 ? 103 LEU A O   1 
ATOM 748   C CB  . LEU A 1 109 ? 28.398  -14.980 -13.654 1.00 106.15 ? 103 LEU A CB  1 
ATOM 749   C CG  . LEU A 1 109 ? 27.108  -15.810 -13.742 1.00 107.08 ? 103 LEU A CG  1 
ATOM 750   C CD1 . LEU A 1 109 ? 27.426  -17.237 -13.366 1.00 111.34 ? 103 LEU A CD1 1 
ATOM 751   C CD2 . LEU A 1 109 ? 25.963  -15.320 -12.887 1.00 106.69 ? 103 LEU A CD2 1 
ATOM 752   N N   . GLN A 1 110 ? 31.293  -13.684 -14.530 1.00 114.74 ? 104 GLN A N   1 
ATOM 753   C CA  . GLN A 1 110 ? 32.730  -13.552 -14.738 1.00 119.80 ? 104 GLN A CA  1 
ATOM 754   C C   . GLN A 1 110 ? 32.981  -13.144 -16.193 1.00 124.38 ? 104 GLN A C   1 
ATOM 755   O O   . GLN A 1 110 ? 34.078  -12.694 -16.532 1.00 127.39 ? 104 GLN A O   1 
ATOM 756   C CB  . GLN A 1 110 ? 33.515  -14.796 -14.312 1.00 118.95 ? 104 GLN A CB  1 
ATOM 757   C CG  . GLN A 1 110 ? 33.712  -15.830 -15.417 1.00 120.96 ? 104 GLN A CG  1 
ATOM 758   C CD  . GLN A 1 110 ? 33.818  -17.245 -14.894 1.00 119.39 ? 104 GLN A CD  1 
ATOM 759   O OE1 . GLN A 1 110 ? 33.983  -17.478 -13.692 1.00 121.21 ? 104 GLN A OE1 1 
ATOM 760   N NE2 . GLN A 1 110 ? 33.729  -18.208 -15.800 1.00 119.73 ? 104 GLN A NE2 1 
ATOM 761   N N   . HIS A 1 111 ? 31.884  -13.212 -16.958 1.00 121.32 ? 105 HIS A N   1 
ATOM 762   C CA  . HIS A 1 111 ? 31.905  -12.644 -18.328 1.00 118.95 ? 105 HIS A CA  1 
ATOM 763   C C   . HIS A 1 111 ? 31.035  -11.390 -18.239 1.00 102.46 ? 105 HIS A C   1 
ATOM 764   O O   . HIS A 1 111 ? 30.512  -10.936 -19.267 1.00 81.04  ? 105 HIS A O   1 
ATOM 765   C CB  . HIS A 1 111 ? 31.376  -13.605 -19.392 1.00 113.49 ? 105 HIS A CB  1 
ATOM 766   C CG  . HIS A 1 111 ? 32.447  -14.218 -20.220 1.00 111.28 ? 105 HIS A CG  1 
ATOM 767   N ND1 . HIS A 1 111 ? 32.210  -14.759 -21.463 1.00 117.56 ? 105 HIS A ND1 1 
ATOM 768   C CD2 . HIS A 1 111 ? 33.750  -14.379 -19.985 1.00 107.75 ? 105 HIS A CD2 1 
ATOM 769   C CE1 . HIS A 1 111 ? 33.345  -15.228 -21.954 1.00 120.03 ? 105 HIS A CE1 1 
ATOM 770   N NE2 . HIS A 1 111 ? 34.294  -15.007 -21.072 1.00 111.40 ? 105 HIS A NE2 1 
ATOM 771   N N   . LYS A 1 112 ? 30.844  -10.874 -17.027 1.00 99.00  ? 106 LYS A N   1 
ATOM 772   C CA  . LYS A 1 112 ? 30.131  -9.588  -16.877 1.00 95.89  ? 106 LYS A CA  1 
ATOM 773   C C   . LYS A 1 112 ? 31.111  -8.594  -16.258 1.00 109.80 ? 106 LYS A C   1 
ATOM 774   O O   . LYS A 1 112 ? 31.721  -8.931  -15.232 1.00 101.33 ? 106 LYS A O   1 
ATOM 775   C CB  . LYS A 1 112 ? 28.908  -9.686  -15.971 1.00 99.62  ? 106 LYS A CB  1 
ATOM 776   C CG  . LYS A 1 112 ? 27.865  -10.715 -16.364 1.00 109.05 ? 106 LYS A CG  1 
ATOM 777   C CD  . LYS A 1 112 ? 27.134  -11.283 -15.153 1.00 109.98 ? 106 LYS A CD  1 
ATOM 778   C CE  . LYS A 1 112 ? 26.089  -10.351 -14.635 1.00 112.77 ? 106 LYS A CE  1 
ATOM 779   N NZ  . LYS A 1 112 ? 25.714  -9.376  -15.661 1.00 116.43 ? 106 LYS A NZ  1 
ATOM 780   N N   . ASP A 1 113 ? 31.237  -7.412  -16.860 1.00 131.47 ? 107 ASP A N   1 
ATOM 781   C CA  . ASP A 1 113 ? 32.187  -6.378  -16.371 1.00 136.41 ? 107 ASP A CA  1 
ATOM 782   C C   . ASP A 1 113 ? 31.546  -5.611  -15.219 1.00 143.65 ? 107 ASP A C   1 
ATOM 783   O O   . ASP A 1 113 ? 30.330  -5.379  -15.275 1.00 133.28 ? 107 ASP A O   1 
ATOM 784   C CB  . ASP A 1 113 ? 32.600  -5.413  -17.473 1.00 121.80 ? 107 ASP A CB  1 
ATOM 785   C CG  . ASP A 1 113 ? 32.128  -5.756  -18.879 1.00 111.90 ? 107 ASP A CG  1 
ATOM 786   O OD1 . ASP A 1 113 ? 32.122  -6.956  -19.219 1.00 97.25  ? 107 ASP A OD1 1 
ATOM 787   O OD2 . ASP A 1 113 ? 31.781  -4.817  -19.624 1.00 100.63 ? 107 ASP A OD2 1 
ATOM 788   N N   . ASP A 1 114 ? 32.336  -5.233  -14.213 1.00 155.47 ? 108 ASP A N   1 
ATOM 789   C CA  . ASP A 1 114 ? 31.766  -4.412  -13.157 1.00 152.35 ? 108 ASP A CA  1 
ATOM 790   C C   . ASP A 1 114 ? 31.737  -2.966  -13.643 1.00 160.81 ? 108 ASP A C   1 
ATOM 791   O O   . ASP A 1 114 ? 30.752  -2.263  -13.426 1.00 167.84 ? 108 ASP A O   1 
ATOM 792   C CB  . ASP A 1 114 ? 32.564  -4.500  -11.861 1.00 146.92 ? 108 ASP A CB  1 
ATOM 793   C CG  . ASP A 1 114 ? 32.504  -5.815  -11.091 1.00 132.36 ? 108 ASP A CG  1 
ATOM 794   O OD1 . ASP A 1 114 ? 31.779  -6.731  -11.538 1.00 124.80 ? 108 ASP A OD1 1 
ATOM 795   O OD2 . ASP A 1 114 ? 33.183  -5.910  -10.039 1.00 106.81 ? 108 ASP A OD2 1 
ATOM 796   N N   . ASN A 1 115 ? 32.837  -2.550  -14.291 1.00 169.41 ? 109 ASN A N   1 
ATOM 797   C CA  . ASN A 1 115 ? 32.952  -1.248  -14.934 1.00 171.11 ? 109 ASN A CA  1 
ATOM 798   C C   . ASN A 1 115 ? 31.938  -1.162  -16.074 1.00 167.94 ? 109 ASN A C   1 
ATOM 799   O O   . ASN A 1 115 ? 32.031  -1.912  -17.053 1.00 121.42 ? 109 ASN A O   1 
ATOM 800   C CB  . ASN A 1 115 ? 34.361  -1.003  -15.471 1.00 163.71 ? 109 ASN A CB  1 
ATOM 801   C CG  . ASN A 1 115 ? 34.747  0.460   -15.547 1.00 149.77 ? 109 ASN A CG  1 
ATOM 802   O OD1 . ASN A 1 115 ? 33.997  1.344   -15.117 1.00 130.84 ? 109 ASN A OD1 1 
ATOM 803   N ND2 . ASN A 1 115 ? 35.929  0.737   -16.076 1.00 148.33 ? 109 ASN A ND2 1 
ATOM 804   N N   . ASN A 1 117 ? 30.418  0.158   -19.508 1.00 151.68 ? 111 ASN A N   1 
ATOM 805   C CA  . ASN A 1 117 ? 31.128  0.649   -20.714 1.00 135.90 ? 111 ASN A CA  1 
ATOM 806   C C   . ASN A 1 117 ? 30.062  1.327   -21.555 1.00 138.29 ? 111 ASN A C   1 
ATOM 807   O O   . ASN A 1 117 ? 30.076  1.150   -22.790 1.00 156.23 ? 111 ASN A O   1 
ATOM 808   C CB  . ASN A 1 117 ? 31.804  -0.482  -21.468 1.00 128.78 ? 111 ASN A CB  1 
ATOM 809   C CG  . ASN A 1 117 ? 33.051  -0.009  -22.173 1.00 137.46 ? 111 ASN A CG  1 
ATOM 810   O OD1 . ASN A 1 117 ? 33.326  1.197   -22.205 1.00 133.65 ? 111 ASN A OD1 1 
ATOM 811   N ND2 . ASN A 1 117 ? 33.818  -0.932  -22.734 1.00 149.09 ? 111 ASN A ND2 1 
ATOM 812   N N   . LEU A 1 118 ? 29.184  2.080   -20.899 1.00 116.51 ? 112 LEU A N   1 
ATOM 813   C CA  . LEU A 1 118 ? 28.030  2.655   -21.621 1.00 107.77 ? 112 LEU A CA  1 
ATOM 814   C C   . LEU A 1 118 ? 27.943  4.129   -21.255 1.00 106.14 ? 112 LEU A C   1 
ATOM 815   O O   . LEU A 1 118 ? 28.397  4.502   -20.157 1.00 97.03  ? 112 LEU A O   1 
ATOM 816   C CB  . LEU A 1 118 ? 26.765  1.890   -21.240 1.00 105.17 ? 112 LEU A CB  1 
ATOM 817   C CG  . LEU A 1 118 ? 26.723  0.406   -21.607 1.00 95.19  ? 112 LEU A CG  1 
ATOM 818   C CD1 . LEU A 1 118 ? 25.578  -0.256  -20.870 1.00 84.25  ? 112 LEU A CD1 1 
ATOM 819   C CD2 . LEU A 1 118 ? 26.543  0.258   -23.102 1.00 99.46  ? 112 LEU A CD2 1 
ATOM 820   N N   . PRO A 1 119 ? 27.375  4.978   -22.128 1.00 109.63 ? 113 PRO A N   1 
ATOM 821   C CA  . PRO A 1 119 ? 27.383  6.399   -21.859 1.00 101.59 ? 113 PRO A CA  1 
ATOM 822   C C   . PRO A 1 119 ? 26.581  6.608   -20.628 1.00 97.04  ? 113 PRO A C   1 
ATOM 823   O O   . PRO A 1 119 ? 25.500  6.027   -20.474 1.00 79.62  ? 113 PRO A O   1 
ATOM 824   C CB  . PRO A 1 119 ? 26.644  6.918   -23.068 1.00 112.20 ? 113 PRO A CB  1 
ATOM 825   C CG  . PRO A 1 119 ? 25.764  5.769   -23.509 1.00 108.34 ? 113 PRO A CG  1 
ATOM 826   C CD  . PRO A 1 119 ? 26.684  4.584   -23.339 1.00 105.73 ? 113 PRO A CD  1 
ATOM 827   N N   . ARG A 1 120 ? 27.050  7.511   -19.786 1.00 106.93 ? 114 ARG A N   1 
ATOM 828   C CA  . ARG A 1 120 ? 26.348  7.690   -18.504 1.00 107.00 ? 114 ARG A CA  1 
ATOM 829   C C   . ARG A 1 120 ? 24.980  8.190   -18.930 1.00 112.25 ? 114 ARG A C   1 
ATOM 830   O O   . ARG A 1 120 ? 24.898  8.913   -19.938 1.00 124.46 ? 114 ARG A O   1 
ATOM 831   C CB  . ARG A 1 120 ? 27.040  8.706   -17.596 1.00 108.08 ? 114 ARG A CB  1 
ATOM 832   C CG  . ARG A 1 120 ? 27.297  8.280   -16.159 1.00 120.01 ? 114 ARG A CG  1 
ATOM 833   C CD  . ARG A 1 120 ? 27.938  9.418   -15.369 1.00 132.14 ? 114 ARG A CD  1 
ATOM 834   N NE  . ARG A 1 120 ? 28.461  9.017   -14.057 1.00 135.83 ? 114 ARG A NE  1 
ATOM 835   C CZ  . ARG A 1 120 ? 29.619  9.427   -13.553 1.00 118.26 ? 114 ARG A CZ  1 
ATOM 836   N NH1 . ARG A 1 120 ? 30.433  10.167  -14.283 1.00 117.40 ? 114 ARG A NH1 1 
ATOM 837   N NH2 . ARG A 1 120 ? 29.960  9.092   -12.321 1.00 106.76 ? 114 ARG A NH2 1 
ATOM 838   N N   . LEU A 1 121 ? 23.952  7.696   -18.264 1.00 101.11 ? 115 LEU A N   1 
ATOM 839   C CA  . LEU A 1 121 ? 22.589  8.108   -18.617 1.00 86.66  ? 115 LEU A CA  1 
ATOM 840   C C   . LEU A 1 121 ? 22.536  9.627   -18.542 1.00 77.05  ? 115 LEU A C   1 
ATOM 841   O O   . LEU A 1 121 ? 22.983  10.180  -17.532 1.00 90.83  ? 115 LEU A O   1 
ATOM 842   C CB  . LEU A 1 121 ? 21.686  7.449   -17.585 1.00 88.54  ? 115 LEU A CB  1 
ATOM 843   C CG  . LEU A 1 121 ? 20.329  6.956   -18.088 1.00 95.58  ? 115 LEU A CG  1 
ATOM 844   C CD1 . LEU A 1 121 ? 20.498  6.365   -19.472 1.00 106.12 ? 115 LEU A CD1 1 
ATOM 845   C CD2 . LEU A 1 121 ? 19.784  5.922   -17.125 1.00 91.00  ? 115 LEU A CD2 1 
ATOM 846   N N   . VAL A 1 122 ? 22.003  10.268  -19.572 1.00 63.24  ? 116 VAL A N   1 
ATOM 847   C CA  . VAL A 1 122 ? 21.796  11.733  -19.479 1.00 58.06  ? 116 VAL A CA  1 
ATOM 848   C C   . VAL A 1 122 ? 20.280  11.849  -19.375 1.00 61.33  ? 116 VAL A C   1 
ATOM 849   O O   . VAL A 1 122 ? 19.575  11.264  -20.205 1.00 61.32  ? 116 VAL A O   1 
ATOM 850   C CB  . VAL A 1 122 ? 22.322  12.519  -20.686 1.00 53.27  ? 116 VAL A CB  1 
ATOM 851   C CG1 . VAL A 1 122 ? 21.635  13.870  -20.824 1.00 47.85  ? 116 VAL A CG1 1 
ATOM 852   C CG2 . VAL A 1 122 ? 23.833  12.686  -20.632 1.00 56.97  ? 116 VAL A CG2 1 
ATOM 853   N N   . ARG A 1 123 ? 19.825  12.512  -18.326 1.00 66.50  ? 117 ARG A N   1 
ATOM 854   C CA  . ARG A 1 123 ? 18.374  12.592  -18.097 1.00 64.25  ? 117 ARG A CA  1 
ATOM 855   C C   . ARG A 1 123 ? 17.738  13.453  -19.176 1.00 63.70  ? 117 ARG A C   1 
ATOM 856   O O   . ARG A 1 123 ? 18.292  14.508  -19.506 1.00 63.85  ? 117 ARG A O   1 
ATOM 857   C CB  . ARG A 1 123 ? 18.163  13.068  -16.657 1.00 63.41  ? 117 ARG A CB  1 
ATOM 858   C CG  . ARG A 1 123 ? 18.004  11.912  -15.682 1.00 64.19  ? 117 ARG A CG  1 
ATOM 859   C CD  . ARG A 1 123 ? 17.501  12.373  -14.329 1.00 73.59  ? 117 ARG A CD  1 
ATOM 860   N NE  . ARG A 1 123 ? 18.589  12.566  -13.365 1.00 77.43  ? 117 ARG A NE  1 
ATOM 861   C CZ  . ARG A 1 123 ? 19.138  11.597  -12.651 1.00 83.61  ? 117 ARG A CZ  1 
ATOM 862   N NH1 . ARG A 1 123 ? 18.555  10.416  -12.575 1.00 91.29  ? 117 ARG A NH1 1 
ATOM 863   N NH2 . ARG A 1 123 ? 20.273  11.812  -12.017 1.00 80.93  ? 117 ARG A NH2 1 
ATOM 864   N N   . PRO A 1 124 ? 16.557  13.077  -19.668 1.00 64.84  ? 118 PRO A N   1 
ATOM 865   C CA  . PRO A 1 124 ? 15.794  13.901  -20.577 1.00 61.83  ? 118 PRO A CA  1 
ATOM 866   C C   . PRO A 1 124 ? 15.270  15.022  -19.702 1.00 59.85  ? 118 PRO A C   1 
ATOM 867   O O   . PRO A 1 124 ? 15.297  14.899  -18.479 1.00 59.78  ? 118 PRO A O   1 
ATOM 868   C CB  . PRO A 1 124 ? 14.733  12.950  -21.077 1.00 62.17  ? 118 PRO A CB  1 
ATOM 869   C CG  . PRO A 1 124 ? 15.269  11.581  -20.756 1.00 64.68  ? 118 PRO A CG  1 
ATOM 870   C CD  . PRO A 1 124 ? 15.944  11.792  -19.423 1.00 63.35  ? 118 PRO A CD  1 
ATOM 871   N N   . GLU A 1 125 ? 14.897  16.147  -20.286 1.00 69.65  ? 119 GLU A N   1 
ATOM 872   C CA  . GLU A 1 125 ? 14.461  17.341  -19.516 1.00 75.83  ? 119 GLU A CA  1 
ATOM 873   C C   . GLU A 1 125 ? 13.176  16.995  -18.767 1.00 74.36  ? 119 GLU A C   1 
ATOM 874   O O   . GLU A 1 125 ? 12.401  16.171  -19.274 1.00 67.71  ? 119 GLU A O   1 
ATOM 875   C CB  . GLU A 1 125 ? 14.286  18.582  -20.389 1.00 83.21  ? 119 GLU A CB  1 
ATOM 876   C CG  . GLU A 1 125 ? 15.585  19.349  -20.617 1.00 87.50  ? 119 GLU A CG  1 
ATOM 877   C CD  . GLU A 1 125 ? 15.656  20.709  -19.949 1.00 95.67  ? 119 GLU A CD  1 
ATOM 878   O OE1 . GLU A 1 125 ? 14.612  21.384  -19.854 1.00 90.38  ? 119 GLU A OE1 1 
ATOM 879   O OE2 . GLU A 1 125 ? 16.764  21.096  -19.526 1.00 101.00 ? 119 GLU A OE2 1 
ATOM 880   N N   . VAL A 1 126 ? 12.948  17.612  -17.610 1.00 68.86  ? 120 VAL A N   1 
ATOM 881   C CA  . VAL A 1 126 ? 11.877  17.156  -16.685 1.00 63.77  ? 120 VAL A CA  1 
ATOM 882   C C   . VAL A 1 126 ? 10.512  17.247  -17.340 1.00 60.67  ? 120 VAL A C   1 
ATOM 883   O O   . VAL A 1 126 ? 9.713   16.340  -17.118 1.00 56.48  ? 120 VAL A O   1 
ATOM 884   C CB  . VAL A 1 126 ? 11.931  18.048  -15.438 1.00 64.07  ? 120 VAL A CB  1 
ATOM 885   C CG1 . VAL A 1 126 ? 11.110  17.474  -14.293 1.00 61.07  ? 120 VAL A CG1 1 
ATOM 886   C CG2 . VAL A 1 126 ? 13.364  18.308  -14.994 1.00 62.94  ? 120 VAL A CG2 1 
ATOM 887   N N   . ASP A 1 127 ? 10.242  18.281  -18.097 1.00 74.64  ? 121 ASP A N   1 
ATOM 888   C CA  . ASP A 1 127 ? 8.888   18.275  -18.691 1.00 88.36  ? 121 ASP A CA  1 
ATOM 889   C C   . ASP A 1 127 ? 8.773   17.052  -19.602 1.00 84.36  ? 121 ASP A C   1 
ATOM 890   O O   . ASP A 1 127 ? 7.705   16.420  -19.617 1.00 71.32  ? 121 ASP A O   1 
ATOM 891   C CB  . ASP A 1 127 ? 8.641   19.571  -19.441 1.00 97.10  ? 121 ASP A CB  1 
ATOM 892   C CG  . ASP A 1 127 ? 9.306   20.811  -18.862 1.00 102.52 ? 121 ASP A CG  1 
ATOM 893   O OD1 . ASP A 1 127 ? 10.495  20.727  -18.492 1.00 103.06 ? 121 ASP A OD1 1 
ATOM 894   O OD2 . ASP A 1 127 ? 8.630   21.857  -18.794 1.00 102.53 ? 121 ASP A OD2 1 
ATOM 895   N N   . VAL A 1 128 ? 9.824   16.757  -20.363 1.00 82.16  ? 122 VAL A N   1 
ATOM 896   C CA  . VAL A 1 128 ? 9.782   15.603  -21.311 1.00 79.51  ? 122 VAL A CA  1 
ATOM 897   C C   . VAL A 1 128 ? 9.623   14.275  -20.559 1.00 68.31  ? 122 VAL A C   1 
ATOM 898   O O   . VAL A 1 128 ? 8.836   13.437  -21.018 1.00 63.61  ? 122 VAL A O   1 
ATOM 899   C CB  . VAL A 1 128 ? 10.990  15.608  -22.269 1.00 79.01  ? 122 VAL A CB  1 
ATOM 900   C CG1 . VAL A 1 128 ? 11.740  16.931  -22.256 1.00 79.83  ? 122 VAL A CG1 1 
ATOM 901   C CG2 . VAL A 1 128 ? 11.924  14.430  -22.051 1.00 82.94  ? 122 VAL A CG2 1 
ATOM 902   N N   . MET A 1 129 ? 10.329  14.111  -19.441 1.00 62.91  ? 123 MET A N   1 
ATOM 903   C CA  . MET A 1 129 ? 10.233  12.864  -18.653 1.00 54.59  ? 123 MET A CA  1 
ATOM 904   C C   . MET A 1 129 ? 8.806   12.743  -18.147 1.00 57.33  ? 123 MET A C   1 
ATOM 905   O O   . MET A 1 129 ? 8.226   11.661  -18.238 1.00 59.81  ? 123 MET A O   1 
ATOM 906   C CB  . MET A 1 129 ? 11.189  12.913  -17.466 1.00 53.00  ? 123 MET A CB  1 
ATOM 907   C CG  . MET A 1 129 ? 12.646  12.825  -17.833 1.00 56.89  ? 123 MET A CG  1 
ATOM 908   S SD  . MET A 1 129 ? 13.664  12.848  -16.347 1.00 63.52  ? 123 MET A SD  1 
ATOM 909   C CE  . MET A 1 129 ? 14.107  11.109  -16.271 1.00 71.80  ? 123 MET A CE  1 
ATOM 910   N N   . CYS A 1 130 ? 8.242   13.855  -17.715 1.00 61.73  ? 124 CYS A N   1 
ATOM 911   C CA  . CYS A 1 130 ? 6.885   13.838  -17.127 1.00 64.70  ? 124 CYS A CA  1 
ATOM 912   C C   . CYS A 1 130 ? 5.871   13.501  -18.224 1.00 63.43  ? 124 CYS A C   1 
ATOM 913   O O   . CYS A 1 130 ? 4.947   12.720  -17.959 1.00 56.62  ? 124 CYS A O   1 
ATOM 914   C CB  . CYS A 1 130 ? 6.609   15.179  -16.463 1.00 68.09  ? 124 CYS A CB  1 
ATOM 915   S SG  . CYS A 1 130 ? 7.251   15.341  -14.777 1.00 76.34  ? 124 CYS A SG  1 
ATOM 916   N N   . THR A 1 131 ? 6.030   14.090  -19.395 1.00 63.88  ? 125 THR A N   1 
ATOM 917   C CA  . THR A 1 131 ? 5.021   13.835  -20.421 1.00 70.75  ? 125 THR A CA  1 
ATOM 918   C C   . THR A 1 131 ? 5.044   12.360  -20.692 1.00 70.84  ? 125 THR A C   1 
ATOM 919   O O   . THR A 1 131 ? 3.980   11.733  -20.674 1.00 67.78  ? 125 THR A O   1 
ATOM 920   C CB  . THR A 1 131 ? 5.318   14.669  -21.661 1.00 71.84  ? 125 THR A CB  1 
ATOM 921   O OG1 . THR A 1 131 ? 5.774   15.926  -21.177 1.00 68.26  ? 125 THR A OG1 1 
ATOM 922   C CG2 . THR A 1 131 ? 4.085   14.879  -22.518 1.00 68.95  ? 125 THR A CG2 1 
ATOM 923   N N   . ALA A 1 132 ? 6.226   11.808  -20.909 1.00 70.37  ? 126 ALA A N   1 
ATOM 924   C CA  . ALA A 1 132 ? 6.304   10.388  -21.285 1.00 68.76  ? 126 ALA A CA  1 
ATOM 925   C C   . ALA A 1 132 ? 5.765   9.512   -20.171 1.00 64.82  ? 126 ALA A C   1 
ATOM 926   O O   . ALA A 1 132 ? 5.042   8.555   -20.462 1.00 56.62  ? 126 ALA A O   1 
ATOM 927   C CB  . ALA A 1 132 ? 7.740   10.059  -21.531 1.00 71.37  ? 126 ALA A CB  1 
ATOM 928   N N   . PHE A 1 133 ? 6.099   9.842   -18.930 1.00 69.48  ? 127 PHE A N   1 
ATOM 929   C CA  . PHE A 1 133 ? 5.650   8.924   -17.864 1.00 73.71  ? 127 PHE A CA  1 
ATOM 930   C C   . PHE A 1 133 ? 4.159   8.930   -17.868 1.00 81.21  ? 127 PHE A C   1 
ATOM 931   O O   . PHE A 1 133 ? 3.545   7.872   -17.713 1.00 81.92  ? 127 PHE A O   1 
ATOM 932   C CB  . PHE A 1 133 ? 6.139   9.450   -16.515 1.00 69.18  ? 127 PHE A CB  1 
ATOM 933   C CG  . PHE A 1 133 ? 5.565   8.789   -15.271 1.00 64.27  ? 127 PHE A CG  1 
ATOM 934   C CD1 . PHE A 1 133 ? 5.951   7.508   -14.899 1.00 61.51  ? 127 PHE A CD1 1 
ATOM 935   C CD2 . PHE A 1 133 ? 4.660   9.460   -14.462 1.00 63.44  ? 127 PHE A CD2 1 
ATOM 936   C CE1 . PHE A 1 133 ? 5.433   6.915   -13.763 1.00 57.72  ? 127 PHE A CE1 1 
ATOM 937   C CE2 . PHE A 1 133 ? 4.146   8.859   -13.327 1.00 63.10  ? 127 PHE A CE2 1 
ATOM 938   C CZ  . PHE A 1 133 ? 4.535   7.591   -12.980 1.00 59.19  ? 127 PHE A CZ  1 
ATOM 939   N N   . HIS A 1 134 ? 3.560   10.108  -18.013 1.00 85.90  ? 128 HIS A N   1 
ATOM 940   C CA  . HIS A 1 134 ? 2.092   10.097  -18.149 1.00 87.49  ? 128 HIS A CA  1 
ATOM 941   C C   . HIS A 1 134 ? 1.652   9.380   -19.420 1.00 89.37  ? 128 HIS A C   1 
ATOM 942   O O   . HIS A 1 134 ? 0.674   8.617   -19.386 1.00 100.73 ? 128 HIS A O   1 
ATOM 943   C CB  . HIS A 1 134 ? 1.618   11.545  -18.264 1.00 88.86  ? 128 HIS A CB  1 
ATOM 944   C CG  . HIS A 1 134 ? 0.166   11.793  -18.057 1.00 92.63  ? 128 HIS A CG  1 
ATOM 945   N ND1 . HIS A 1 134 ? -0.723  10.859  -17.574 1.00 101.08 ? 128 HIS A ND1 1 
ATOM 946   C CD2 . HIS A 1 134 ? -0.542  12.906  -18.269 1.00 90.36  ? 128 HIS A CD2 1 
ATOM 947   C CE1 . HIS A 1 134 ? -1.928  11.404  -17.504 1.00 99.23  ? 128 HIS A CE1 1 
ATOM 948   N NE2 . HIS A 1 134 ? -1.840  12.648  -17.923 1.00 94.17  ? 128 HIS A NE2 1 
ATOM 949   N N   . ASP A 1 135 ? 2.331   9.655   -20.533 1.00 81.09  ? 129 ASP A N   1 
ATOM 950   C CA  . ASP A 1 135 ? 1.831   9.056   -21.797 1.00 78.39  ? 129 ASP A CA  1 
ATOM 951   C C   . ASP A 1 135 ? 1.899   7.526   -21.890 1.00 84.42  ? 129 ASP A C   1 
ATOM 952   O O   . ASP A 1 135 ? 0.905   6.945   -22.350 1.00 90.34  ? 129 ASP A O   1 
ATOM 953   C CB  . ASP A 1 135 ? 2.499   9.738   -22.978 1.00 82.41  ? 129 ASP A CB  1 
ATOM 954   C CG  . ASP A 1 135 ? 2.068   11.174  -23.232 1.00 88.04  ? 129 ASP A CG  1 
ATOM 955   O OD1 . ASP A 1 135 ? 1.621   11.828  -22.269 1.00 93.51  ? 129 ASP A OD1 1 
ATOM 956   O OD2 . ASP A 1 135 ? 2.181   11.623  -24.390 1.00 81.10  ? 129 ASP A OD2 1 
ATOM 957   N N   . ASN A 1 136 ? 3.002   6.883   -21.480 1.00 94.14  ? 130 ASN A N   1 
ATOM 958   C CA  . ASN A 1 136 ? 3.030   5.391   -21.464 1.00 90.85  ? 130 ASN A CA  1 
ATOM 959   C C   . ASN A 1 136 ? 3.070   4.813   -20.056 1.00 93.35  ? 130 ASN A C   1 
ATOM 960   O O   . ASN A 1 136 ? 2.340   3.843   -19.789 1.00 99.38  ? 130 ASN A O   1 
ATOM 961   C CB  . ASN A 1 136 ? 4.258   4.853   -22.175 1.00 95.56  ? 130 ASN A CB  1 
ATOM 962   C CG  . ASN A 1 136 ? 4.853   5.840   -23.149 1.00 97.77  ? 130 ASN A CG  1 
ATOM 963   O OD1 . ASN A 1 136 ? 4.157   6.327   -24.045 1.00 99.45  ? 130 ASN A OD1 1 
ATOM 964   N ND2 . ASN A 1 136 ? 6.137   6.133   -23.003 1.00 93.70  ? 130 ASN A ND2 1 
ATOM 965   N N   . GLU A 1 137 ? 3.971   5.335   -19.235 1.00 87.23  ? 131 GLU A N   1 
ATOM 966   C CA  . GLU A 1 137 ? 4.129   4.916   -17.823 1.00 81.12  ? 131 GLU A CA  1 
ATOM 967   C C   . GLU A 1 137 ? 4.739   3.515   -17.801 1.00 80.45  ? 131 GLU A C   1 
ATOM 968   O O   . GLU A 1 137 ? 5.822   3.348   -17.233 1.00 70.09  ? 131 GLU A O   1 
ATOM 969   C CB  . GLU A 1 137 ? 2.828   4.967   -17.035 1.00 93.70  ? 131 GLU A CB  1 
ATOM 970   C CG  . GLU A 1 137 ? 3.024   4.681   -15.550 1.00 110.49 ? 131 GLU A CG  1 
ATOM 971   C CD  . GLU A 1 137 ? 2.120   5.471   -14.624 1.00 114.49 ? 131 GLU A CD  1 
ATOM 972   O OE1 . GLU A 1 137 ? 1.387   6.354   -15.114 1.00 120.82 ? 131 GLU A OE1 1 
ATOM 973   O OE2 . GLU A 1 137 ? 2.150   5.202   -13.408 1.00 105.36 ? 131 GLU A OE2 1 
ATOM 974   N N   . GLU A 1 138 ? 4.055   2.546   -18.410 1.00 82.43  ? 132 GLU A N   1 
ATOM 975   C CA  . GLU A 1 138 ? 4.608   1.182   -18.321 1.00 82.34  ? 132 GLU A CA  1 
ATOM 976   C C   . GLU A 1 138 ? 5.958   1.067   -19.013 1.00 76.92  ? 132 GLU A C   1 
ATOM 977   O O   . GLU A 1 138 ? 6.877   0.496   -18.414 1.00 68.57  ? 132 GLU A O   1 
ATOM 978   C CB  . GLU A 1 138 ? 3.663   0.295   -19.118 1.00 93.39  ? 132 GLU A CB  1 
ATOM 979   C CG  . GLU A 1 138 ? 4.324   -0.962  -19.674 1.00 107.42 ? 132 GLU A CG  1 
ATOM 980   C CD  . GLU A 1 138 ? 3.532   -2.230  -19.423 1.00 121.20 ? 132 GLU A CD  1 
ATOM 981   O OE1 . GLU A 1 138 ? 2.304   -2.205  -19.648 1.00 137.58 ? 132 GLU A OE1 1 
ATOM 982   O OE2 . GLU A 1 138 ? 4.138   -3.239  -19.003 1.00 117.25 ? 132 GLU A OE2 1 
ATOM 983   N N   . THR A 1 139 ? 6.082   1.651   -20.204 1.00 69.93  ? 133 THR A N   1 
ATOM 984   C CA  . THR A 1 139 ? 7.387   1.655   -20.886 1.00 69.26  ? 133 THR A CA  1 
ATOM 985   C C   . THR A 1 139 ? 8.393   2.454   -20.102 1.00 60.12  ? 133 THR A C   1 
ATOM 986   O O   . THR A 1 139 ? 9.549   2.028   -20.023 1.00 56.53  ? 133 THR A O   1 
ATOM 987   C CB  . THR A 1 139 ? 7.223   2.124   -22.328 1.00 67.71  ? 133 THR A CB  1 
ATOM 988   O OG1 . THR A 1 139 ? 7.239   3.544   -22.262 1.00 62.92  ? 133 THR A OG1 1 
ATOM 989   C CG2 . THR A 1 139 ? 5.929   1.629   -22.947 1.00 68.77  ? 133 THR A CG2 1 
ATOM 990   N N   . PHE A 1 140 ? 7.974   3.597   -19.568 1.00 52.28  ? 134 PHE A N   1 
ATOM 991   C CA  . PHE A 1 140 ? 8.968   4.465   -18.907 1.00 52.94  ? 134 PHE A CA  1 
ATOM 992   C C   . PHE A 1 140 ? 9.584   3.807   -17.702 1.00 61.59  ? 134 PHE A C   1 
ATOM 993   O O   . PHE A 1 140 ? 10.807  3.924   -17.520 1.00 66.62  ? 134 PHE A O   1 
ATOM 994   C CB  . PHE A 1 140 ? 8.061   5.629   -18.521 1.00 53.72  ? 134 PHE A CB  1 
ATOM 995   C CG  . PHE A 1 140 ? 8.781   6.827   -17.926 1.00 56.69  ? 134 PHE A CG  1 
ATOM 996   C CD1 . PHE A 1 140 ? 9.284   7.831   -18.739 1.00 56.08  ? 134 PHE A CD1 1 
ATOM 997   C CD2 . PHE A 1 140 ? 8.955   6.939   -16.556 1.00 55.25  ? 134 PHE A CD2 1 
ATOM 998   C CE1 . PHE A 1 140 ? 9.946   8.914   -18.193 1.00 53.26  ? 134 PHE A CE1 1 
ATOM 999   C CE2 . PHE A 1 140 ? 9.616   8.025   -16.021 1.00 52.32  ? 134 PHE A CE2 1 
ATOM 1000  C CZ  . PHE A 1 140 ? 10.108  9.008   -16.837 1.00 50.01  ? 134 PHE A CZ  1 
ATOM 1001  N N   . LEU A 1 141 ? 8.774   3.147   -16.881 1.00 66.02  ? 135 LEU A N   1 
ATOM 1002  C CA  . LEU A 1 141 ? 9.260   2.367   -15.716 1.00 57.21  ? 135 LEU A CA  1 
ATOM 1003  C C   . LEU A 1 141 ? 10.120  1.171   -16.144 1.00 56.90  ? 135 LEU A C   1 
ATOM 1004  O O   . LEU A 1 141 ? 11.123  0.894   -15.481 1.00 53.85  ? 135 LEU A O   1 
ATOM 1005  C CB  . LEU A 1 141 ? 8.019   2.018   -14.908 1.00 57.81  ? 135 LEU A CB  1 
ATOM 1006  C CG  . LEU A 1 141 ? 7.199   3.216   -14.426 1.00 63.99  ? 135 LEU A CG  1 
ATOM 1007  C CD1 . LEU A 1 141 ? 6.014   2.750   -13.612 1.00 67.31  ? 135 LEU A CD1 1 
ATOM 1008  C CD2 . LEU A 1 141 ? 8.064   4.169   -13.629 1.00 64.95  ? 135 LEU A CD2 1 
ATOM 1009  N N   . LYS A 1 142 ? 9.720   0.487   -17.209 1.00 55.60  ? 136 LYS A N   1 
ATOM 1010  C CA  . LYS A 1 142 ? 10.457  -0.687  -17.722 1.00 57.59  ? 136 LYS A CA  1 
ATOM 1011  C C   . LYS A 1 142 ? 11.845  -0.243  -18.169 1.00 57.70  ? 136 LYS A C   1 
ATOM 1012  O O   . LYS A 1 142 ? 12.815  -0.962  -17.926 1.00 51.03  ? 136 LYS A O   1 
ATOM 1013  C CB  . LYS A 1 142 ? 9.669   -1.221  -18.914 1.00 63.65  ? 136 LYS A CB  1 
ATOM 1014  C CG  . LYS A 1 142 ? 8.850   -2.478  -18.699 1.00 69.46  ? 136 LYS A CG  1 
ATOM 1015  C CD  . LYS A 1 142 ? 8.604   -3.233  -19.999 1.00 74.67  ? 136 LYS A CD  1 
ATOM 1016  C CE  . LYS A 1 142 ? 7.149   -3.411  -20.285 1.00 81.58  ? 136 LYS A CE  1 
ATOM 1017  N NZ  . LYS A 1 142 ? 6.915   -4.188  -21.504 1.00 84.60  ? 136 LYS A NZ  1 
ATOM 1018  N N   . LYS A 1 143 ? 11.923  0.915   -18.798 1.00 56.93  ? 137 LYS A N   1 
ATOM 1019  C CA  . LYS A 1 143 ? 13.215  1.411   -19.307 1.00 58.02  ? 137 LYS A CA  1 
ATOM 1020  C C   . LYS A 1 143 ? 14.136  1.611   -18.111 1.00 56.49  ? 137 LYS A C   1 
ATOM 1021  O O   . LYS A 1 143 ? 15.329  1.334   -18.237 1.00 51.04  ? 137 LYS A O   1 
ATOM 1022  C CB  . LYS A 1 143 ? 12.942  2.686   -20.102 1.00 60.34  ? 137 LYS A CB  1 
ATOM 1023  C CG  . LYS A 1 143 ? 12.415  2.502   -21.511 1.00 64.60  ? 137 LYS A CG  1 
ATOM 1024  C CD  . LYS A 1 143 ? 12.593  3.757   -22.354 1.00 69.46  ? 137 LYS A CD  1 
ATOM 1025  C CE  . LYS A 1 143 ? 12.171  3.564   -23.771 1.00 75.10  ? 137 LYS A CE  1 
ATOM 1026  N NZ  . LYS A 1 143 ? 10.748  3.234   -23.870 1.00 77.72  ? 137 LYS A NZ  1 
ATOM 1027  N N   . TYR A 1 144 ? 13.600  2.123   -17.013 1.00 61.34  ? 138 TYR A N   1 
ATOM 1028  C CA  . TYR A 1 144 ? 14.406  2.282   -15.778 1.00 71.33  ? 138 TYR A CA  1 
ATOM 1029  C C   . TYR A 1 144 ? 15.011  0.951   -15.400 1.00 65.77  ? 138 TYR A C   1 
ATOM 1030  O O   . TYR A 1 144 ? 16.243  0.830   -15.324 1.00 54.76  ? 138 TYR A O   1 
ATOM 1031  C CB  . TYR A 1 144 ? 13.507  2.794   -14.656 1.00 78.01  ? 138 TYR A CB  1 
ATOM 1032  C CG  . TYR A 1 144 ? 14.228  3.116   -13.358 1.00 88.03  ? 138 TYR A CG  1 
ATOM 1033  C CD1 . TYR A 1 144 ? 14.993  4.265   -13.229 1.00 108.09 ? 138 TYR A CD1 1 
ATOM 1034  C CD2 . TYR A 1 144 ? 14.138  2.268   -12.263 1.00 86.31  ? 138 TYR A CD2 1 
ATOM 1035  C CE1 . TYR A 1 144 ? 15.647  4.562   -12.047 1.00 116.07 ? 138 TYR A CE1 1 
ATOM 1036  C CE2 . TYR A 1 144 ? 14.791  2.551   -11.076 1.00 90.95  ? 138 TYR A CE2 1 
ATOM 1037  C CZ  . TYR A 1 144 ? 15.547  3.702   -10.970 1.00 114.92 ? 138 TYR A CZ  1 
ATOM 1038  O OH  . TYR A 1 144 ? 16.194  3.980   -9.804  1.00 151.33 ? 138 TYR A OH  1 
ATOM 1039  N N   . LEU A 1 145 ? 14.153  -0.035  -15.155 1.00 61.47  ? 139 LEU A N   1 
ATOM 1040  C CA  . LEU A 1 145 ? 14.664  -1.348  -14.801 1.00 56.73  ? 139 LEU A CA  1 
ATOM 1041  C C   . LEU A 1 145 ? 15.783  -1.706  -15.776 1.00 55.77  ? 139 LEU A C   1 
ATOM 1042  O O   . LEU A 1 145 ? 16.876  -2.087  -15.348 1.00 49.76  ? 139 LEU A O   1 
ATOM 1043  C CB  . LEU A 1 145 ? 13.526  -2.370  -14.830 1.00 50.69  ? 139 LEU A CB  1 
ATOM 1044  C CG  . LEU A 1 145 ? 12.398  -2.130  -13.824 1.00 50.28  ? 139 LEU A CG  1 
ATOM 1045  C CD1 . LEU A 1 145 ? 11.157  -2.954  -14.096 1.00 48.99  ? 139 LEU A CD1 1 
ATOM 1046  C CD2 . LEU A 1 145 ? 12.936  -2.418  -12.440 1.00 54.53  ? 139 LEU A CD2 1 
ATOM 1047  N N   . TYR A 1 146 ? 15.498  -1.515  -17.077 1.00 54.00  ? 140 TYR A N   1 
ATOM 1048  C CA  . TYR A 1 146 ? 16.437  -1.831  -18.141 1.00 51.37  ? 140 TYR A CA  1 
ATOM 1049  C C   . TYR A 1 146 ? 17.750  -1.073  -17.913 1.00 54.63  ? 140 TYR A C   1 
ATOM 1050  O O   . TYR A 1 146 ? 18.816  -1.680  -17.860 1.00 47.95  ? 140 TYR A O   1 
ATOM 1051  C CB  . TYR A 1 146 ? 15.805  -1.579  -19.516 1.00 47.63  ? 140 TYR A CB  1 
ATOM 1052  C CG  . TYR A 1 146 ? 16.810  -1.594  -20.663 1.00 47.75  ? 140 TYR A CG  1 
ATOM 1053  C CD1 . TYR A 1 146 ? 17.370  -2.774  -21.114 1.00 49.77  ? 140 TYR A CD1 1 
ATOM 1054  C CD2 . TYR A 1 146 ? 17.210  -0.425  -21.294 1.00 49.45  ? 140 TYR A CD2 1 
ATOM 1055  C CE1 . TYR A 1 146 ? 18.294  -2.790  -22.145 1.00 52.03  ? 140 TYR A CE1 1 
ATOM 1056  C CE2 . TYR A 1 146 ? 18.144  -0.425  -22.316 1.00 47.36  ? 140 TYR A CE2 1 
ATOM 1057  C CZ  . TYR A 1 146 ? 18.683  -1.615  -22.752 1.00 49.31  ? 140 TYR A CZ  1 
ATOM 1058  O OH  . TYR A 1 146 ? 19.599  -1.663  -23.764 1.00 51.03  ? 140 TYR A OH  1 
ATOM 1059  N N   . GLU A 1 147 ? 17.710  0.236   -17.766 1.00 58.77  ? 141 GLU A N   1 
ATOM 1060  C CA  . GLU A 1 147 ? 19.003  0.965   -17.751 1.00 63.81  ? 141 GLU A CA  1 
ATOM 1061  C C   . GLU A 1 147 ? 19.812  0.675   -16.481 1.00 66.47  ? 141 GLU A C   1 
ATOM 1062  O O   . GLU A 1 147 ? 21.017  0.442   -16.597 1.00 64.68  ? 141 GLU A O   1 
ATOM 1063  C CB  . GLU A 1 147 ? 18.739  2.440   -18.047 1.00 63.52  ? 141 GLU A CB  1 
ATOM 1064  C CG  . GLU A 1 147 ? 18.169  2.681   -19.441 1.00 63.86  ? 141 GLU A CG  1 
ATOM 1065  C CD  . GLU A 1 147 ? 19.217  2.880   -20.517 1.00 67.97  ? 141 GLU A CD  1 
ATOM 1066  O OE1 . GLU A 1 147 ? 20.391  2.557   -20.264 1.00 70.03  ? 141 GLU A OE1 1 
ATOM 1067  O OE2 . GLU A 1 147 ? 18.860  3.355   -21.611 1.00 70.05  ? 141 GLU A OE2 1 
ATOM 1068  N N   . ILE A 1 148 ? 19.197  0.700   -15.311 1.00 70.89  ? 142 ILE A N   1 
ATOM 1069  C CA  . ILE A 1 148 ? 20.050  0.501   -14.112 1.00 69.95  ? 142 ILE A CA  1 
ATOM 1070  C C   . ILE A 1 148 ? 20.669  -0.896  -14.190 1.00 68.84  ? 142 ILE A C   1 
ATOM 1071  O O   . ILE A 1 148 ? 21.857  -1.035  -13.881 1.00 61.08  ? 142 ILE A O   1 
ATOM 1072  C CB  . ILE A 1 148 ? 19.201  0.660   -12.840 1.00 68.61  ? 142 ILE A CB  1 
ATOM 1073  C CG1 . ILE A 1 148 ? 18.331  1.910   -12.906 1.00 79.18  ? 142 ILE A CG1 1 
ATOM 1074  C CG2 . ILE A 1 148 ? 20.063  0.638   -11.580 1.00 57.45  ? 142 ILE A CG2 1 
ATOM 1075  C CD1 . ILE A 1 148 ? 19.048  3.185   -12.507 1.00 74.56  ? 142 ILE A CD1 1 
ATOM 1076  N N   . ALA A 1 149 ? 19.887  -1.890  -14.588 1.00 71.60  ? 143 ALA A N   1 
ATOM 1077  C CA  . ALA A 1 149 ? 20.437  -3.260  -14.595 1.00 71.57  ? 143 ALA A CA  1 
ATOM 1078  C C   . ALA A 1 149 ? 21.592  -3.434  -15.571 1.00 68.14  ? 143 ALA A C   1 
ATOM 1079  O O   . ALA A 1 149 ? 22.538  -4.126  -15.234 1.00 69.82  ? 143 ALA A O   1 
ATOM 1080  C CB  . ALA A 1 149 ? 19.341  -4.217  -14.942 1.00 69.39  ? 143 ALA A CB  1 
ATOM 1081  N N   . ARG A 1 150 ? 21.503  -2.891  -16.776 1.00 70.06  ? 144 ARG A N   1 
ATOM 1082  C CA  . ARG A 1 150 ? 22.667  -3.109  -17.658 1.00 65.41  ? 144 ARG A CA  1 
ATOM 1083  C C   . ARG A 1 150 ? 23.892  -2.430  -17.065 1.00 55.12  ? 144 ARG A C   1 
ATOM 1084  O O   . ARG A 1 150 ? 24.945  -3.041  -17.019 1.00 42.19  ? 144 ARG A O   1 
ATOM 1085  C CB  . ARG A 1 150 ? 22.279  -2.549  -19.028 1.00 70.75  ? 144 ARG A CB  1 
ATOM 1086  C CG  . ARG A 1 150 ? 21.809  -1.106  -19.080 1.00 72.70  ? 144 ARG A CG  1 
ATOM 1087  C CD  . ARG A 1 150 ? 21.161  -0.799  -20.409 1.00 73.36  ? 144 ARG A CD  1 
ATOM 1088  N NE  . ARG A 1 150 ? 22.084  -1.013  -21.526 1.00 76.85  ? 144 ARG A NE  1 
ATOM 1089  C CZ  . ARG A 1 150 ? 22.263  -0.140  -22.502 1.00 87.78  ? 144 ARG A CZ  1 
ATOM 1090  N NH1 . ARG A 1 150 ? 22.219  1.152   -22.245 1.00 84.77  ? 144 ARG A NH1 1 
ATOM 1091  N NH2 . ARG A 1 150 ? 22.476  -0.565  -23.732 1.00 107.91 ? 144 ARG A NH2 1 
ATOM 1092  N N   . ARG A 1 151 ? 23.706  -1.215  -16.570 1.00 60.27  ? 145 ARG A N   1 
ATOM 1093  C CA  . ARG A 1 151 ? 24.815  -0.479  -15.928 1.00 66.35  ? 145 ARG A CA  1 
ATOM 1094  C C   . ARG A 1 151 ? 25.274  -1.207  -14.665 1.00 71.88  ? 145 ARG A C   1 
ATOM 1095  O O   . ARG A 1 151 ? 26.485  -1.283  -14.434 1.00 96.23  ? 145 ARG A O   1 
ATOM 1096  C CB  . ARG A 1 151 ? 24.376  0.958   -15.649 1.00 65.73  ? 145 ARG A CB  1 
ATOM 1097  C CG  . ARG A 1 151 ? 23.832  1.667   -16.878 1.00 72.18  ? 145 ARG A CG  1 
ATOM 1098  C CD  . ARG A 1 151 ? 24.212  3.134   -16.900 1.00 76.33  ? 145 ARG A CD  1 
ATOM 1099  N NE  . ARG A 1 151 ? 24.371  3.625   -18.271 1.00 69.98  ? 145 ARG A NE  1 
ATOM 1100  C CZ  . ARG A 1 151 ? 23.375  3.737   -19.130 1.00 70.06  ? 145 ARG A CZ  1 
ATOM 1101  N NH1 . ARG A 1 151 ? 22.147  3.442   -18.753 1.00 69.66  ? 145 ARG A NH1 1 
ATOM 1102  N NH2 . ARG A 1 151 ? 23.607  4.147   -20.362 1.00 69.80  ? 145 ARG A NH2 1 
ATOM 1103  N N   . HIS A 1 152 ? 24.338  -1.784  -13.909 1.00 66.97  ? 146 HIS A N   1 
ATOM 1104  C CA  . HIS A 1 152 ? 24.689  -2.441  -12.623 1.00 69.56  ? 146 HIS A CA  1 
ATOM 1105  C C   . HIS A 1 152 ? 24.241  -3.899  -12.653 1.00 63.52  ? 146 HIS A C   1 
ATOM 1106  O O   . HIS A 1 152 ? 23.082  -4.185  -12.324 1.00 52.93  ? 146 HIS A O   1 
ATOM 1107  C CB  . HIS A 1 152 ? 24.053  -1.683  -11.459 1.00 69.61  ? 146 HIS A CB  1 
ATOM 1108  C CG  . HIS A 1 152 ? 24.267  -0.212  -11.509 1.00 67.89  ? 146 HIS A CG  1 
ATOM 1109  N ND1 . HIS A 1 152 ? 25.515  0.361   -11.422 1.00 69.18  ? 146 HIS A ND1 1 
ATOM 1110  C CD2 . HIS A 1 152 ? 23.404  0.797   -11.638 1.00 80.55  ? 146 HIS A CD2 1 
ATOM 1111  C CE1 . HIS A 1 152 ? 25.394  1.676   -11.499 1.00 75.60  ? 146 HIS A CE1 1 
ATOM 1112  N NE2 . HIS A 1 152 ? 24.120  1.962   -11.630 1.00 85.68  ? 146 HIS A NE2 1 
ATOM 1113  N N   . PRO A 1 153 ? 25.139  -4.849  -12.977 1.00 67.90  ? 147 PRO A N   1 
ATOM 1114  C CA  . PRO A 1 153 ? 24.739  -6.240  -13.145 1.00 61.73  ? 147 PRO A CA  1 
ATOM 1115  C C   . PRO A 1 153 ? 24.774  -7.186  -11.953 1.00 59.47  ? 147 PRO A C   1 
ATOM 1116  O O   . PRO A 1 153 ? 24.664  -8.403  -12.161 1.00 53.15  ? 147 PRO A O   1 
ATOM 1117  C CB  . PRO A 1 153 ? 25.805  -6.594  -14.179 1.00 62.88  ? 147 PRO A CB  1 
ATOM 1118  C CG  . PRO A 1 153 ? 27.057  -5.945  -13.658 1.00 62.61  ? 147 PRO A CG  1 
ATOM 1119  C CD  . PRO A 1 153 ? 26.556  -4.602  -13.180 1.00 66.04  ? 147 PRO A CD  1 
ATOM 1120  N N   . TYR A 1 154 ? 24.920  -6.649  -10.741 1.00 67.71  ? 148 TYR A N   1 
ATOM 1121  C CA  . TYR A 1 154 ? 24.995  -7.489  -9.516  1.00 66.49  ? 148 TYR A CA  1 
ATOM 1122  C C   . TYR A 1 154 ? 24.006  -6.963  -8.481  1.00 59.95  ? 148 TYR A C   1 
ATOM 1123  O O   . TYR A 1 154 ? 24.068  -7.394  -7.331  1.00 54.34  ? 148 TYR A O   1 
ATOM 1124  C CB  . TYR A 1 154 ? 26.450  -7.504  -9.047  1.00 72.57  ? 148 TYR A CB  1 
ATOM 1125  C CG  . TYR A 1 154 ? 27.365  -8.376  -9.894  1.00 81.19  ? 148 TYR A CG  1 
ATOM 1126  C CD1 . TYR A 1 154 ? 27.275  -9.760  -9.849  1.00 91.99  ? 148 TYR A CD1 1 
ATOM 1127  C CD2 . TYR A 1 154 ? 28.310  -7.815  -10.742 1.00 80.80  ? 148 TYR A CD2 1 
ATOM 1128  C CE1 . TYR A 1 154 ? 28.100  -10.561 -10.620 1.00 92.52  ? 148 TYR A CE1 1 
ATOM 1129  C CE2 . TYR A 1 154 ? 29.142  -8.605  -11.517 1.00 79.16  ? 148 TYR A CE2 1 
ATOM 1130  C CZ  . TYR A 1 154 ? 29.036  -9.981  -11.455 1.00 87.82  ? 148 TYR A CZ  1 
ATOM 1131  O OH  . TYR A 1 154 ? 29.851  -10.768 -12.214 1.00 100.93 ? 148 TYR A OH  1 
ATOM 1132  N N   . PHE A 1 155 ? 23.100  -6.081  -8.890  1.00 58.88  ? 149 PHE A N   1 
ATOM 1133  C CA  . PHE A 1 155 ? 22.065  -5.521  -7.996  1.00 60.45  ? 149 PHE A CA  1 
ATOM 1134  C C   . PHE A 1 155 ? 21.098  -6.579  -7.559  1.00 58.23  ? 149 PHE A C   1 
ATOM 1135  O O   . PHE A 1 155 ? 20.682  -7.382  -8.399  1.00 53.90  ? 149 PHE A O   1 
ATOM 1136  C CB  . PHE A 1 155 ? 21.334  -4.532  -8.898  1.00 64.78  ? 149 PHE A CB  1 
ATOM 1137  C CG  . PHE A 1 155 ? 20.865  -3.227  -8.268  1.00 73.08  ? 149 PHE A CG  1 
ATOM 1138  C CD1 . PHE A 1 155 ? 19.797  -3.201  -7.381  1.00 70.25  ? 149 PHE A CD1 1 
ATOM 1139  C CD2 . PHE A 1 155 ? 21.476  -2.021  -8.588  1.00 72.58  ? 149 PHE A CD2 1 
ATOM 1140  C CE1 . PHE A 1 155 ? 19.369  -2.010  -6.820  1.00 64.18  ? 149 PHE A CE1 1 
ATOM 1141  C CE2 . PHE A 1 155 ? 21.042  -0.834  -8.023  1.00 65.57  ? 149 PHE A CE2 1 
ATOM 1142  C CZ  . PHE A 1 155 ? 19.990  -0.832  -7.143  1.00 64.79  ? 149 PHE A CZ  1 
ATOM 1143  N N   . TYR A 1 156 ? 20.680  -6.540  -6.290  1.00 61.13  ? 150 TYR A N   1 
ATOM 1144  C CA  . TYR A 1 156 ? 19.646  -7.498  -5.855  1.00 58.42  ? 150 TYR A CA  1 
ATOM 1145  C C   . TYR A 1 156 ? 18.419  -7.171  -6.617  1.00 53.82  ? 150 TYR A C   1 
ATOM 1146  O O   . TYR A 1 156 ? 17.991  -6.018  -6.629  1.00 52.24  ? 150 TYR A O   1 
ATOM 1147  C CB  . TYR A 1 156 ? 19.530  -7.050  -4.403  1.00 57.44  ? 150 TYR A CB  1 
ATOM 1148  C CG  . TYR A 1 156 ? 18.989  -7.984  -3.334  1.00 58.36  ? 150 TYR A CG  1 
ATOM 1149  C CD1 . TYR A 1 156 ? 19.240  -9.347  -3.353  1.00 57.72  ? 150 TYR A CD1 1 
ATOM 1150  C CD2 . TYR A 1 156 ? 18.255  -7.472  -2.275  1.00 63.50  ? 150 TYR A CD2 1 
ATOM 1151  C CE1 . TYR A 1 156 ? 18.750  -10.178 -2.360  1.00 59.98  ? 150 TYR A CE1 1 
ATOM 1152  C CE2 . TYR A 1 156 ? 17.763  -8.290  -1.276  1.00 68.74  ? 150 TYR A CE2 1 
ATOM 1153  C CZ  . TYR A 1 156 ? 18.011  -9.647  -1.320  1.00 64.99  ? 150 TYR A CZ  1 
ATOM 1154  O OH  . TYR A 1 156 ? 17.518  -10.433 -0.325  1.00 58.10  ? 150 TYR A OH  1 
ATOM 1155  N N   . ALA A 1 157 ? 17.777  -8.189  -7.150  1.00 51.14  ? 151 ALA A N   1 
ATOM 1156  C CA  . ALA A 1 157 ? 16.521  -7.972  -7.885  1.00 58.03  ? 151 ALA A CA  1 
ATOM 1157  C C   . ALA A 1 157 ? 15.401  -7.431  -7.008  1.00 55.89  ? 151 ALA A C   1 
ATOM 1158  O O   . ALA A 1 157 ? 14.650  -6.567  -7.470  1.00 52.05  ? 151 ALA A O   1 
ATOM 1159  C CB  . ALA A 1 157 ? 16.132  -9.276  -8.505  1.00 63.91  ? 151 ALA A CB  1 
ATOM 1160  N N   . PRO A 1 158 ? 15.220  -7.932  -5.773  1.00 61.13  ? 152 PRO A N   1 
ATOM 1161  C CA  . PRO A 1 158 ? 14.098  -7.482  -4.980  1.00 64.25  ? 152 PRO A CA  1 
ATOM 1162  C C   . PRO A 1 158 ? 14.126  -6.017  -4.628  1.00 70.51  ? 152 PRO A C   1 
ATOM 1163  O O   . PRO A 1 158 ? 13.075  -5.373  -4.698  1.00 78.41  ? 152 PRO A O   1 
ATOM 1164  C CB  . PRO A 1 158 ? 14.370  -8.372  -3.779  1.00 66.64  ? 152 PRO A CB  1 
ATOM 1165  C CG  . PRO A 1 158 ? 14.871  -9.648  -4.367  1.00 67.03  ? 152 PRO A CG  1 
ATOM 1166  C CD  . PRO A 1 158 ? 15.972  -9.013  -5.158  1.00 67.65  ? 152 PRO A CD  1 
ATOM 1167  N N   . GLU A 1 159 ? 15.294  -5.492  -4.266  1.00 73.77  ? 153 GLU A N   1 
ATOM 1168  C CA  . GLU A 1 159 ? 15.444  -4.049  -3.956  1.00 69.46  ? 153 GLU A CA  1 
ATOM 1169  C C   . GLU A 1 159 ? 15.150  -3.240  -5.217  1.00 57.79  ? 153 GLU A C   1 
ATOM 1170  O O   . GLU A 1 159 ? 14.516  -2.190  -5.132  1.00 47.47  ? 153 GLU A O   1 
ATOM 1171  C CB  . GLU A 1 159 ? 16.846  -3.839  -3.397  1.00 75.08  ? 153 GLU A CB  1 
ATOM 1172  C CG  . GLU A 1 159 ? 17.088  -2.428  -2.877  1.00 84.96  ? 153 GLU A CG  1 
ATOM 1173  C CD  . GLU A 1 159 ? 17.032  -2.350  -1.366  1.00 93.11  ? 153 GLU A CD  1 
ATOM 1174  O OE1 . GLU A 1 159 ? 15.947  -2.614  -0.814  1.00 94.66  ? 153 GLU A OE1 1 
ATOM 1175  O OE2 . GLU A 1 159 ? 18.066  -2.033  -0.746  1.00 94.78  ? 153 GLU A OE2 1 
ATOM 1176  N N   . LEU A 1 160 ? 15.631  -3.737  -6.342  1.00 55.72  ? 154 LEU A N   1 
ATOM 1177  C CA  . LEU A 1 160 ? 15.433  -3.025  -7.616  1.00 57.52  ? 154 LEU A CA  1 
ATOM 1178  C C   . LEU A 1 160 ? 13.936  -2.914  -7.818  1.00 56.59  ? 154 LEU A C   1 
ATOM 1179  O O   . LEU A 1 160 ? 13.451  -1.811  -8.067  1.00 63.48  ? 154 LEU A O   1 
ATOM 1180  C CB  . LEU A 1 160 ? 16.094  -3.790  -8.755  1.00 57.24  ? 154 LEU A CB  1 
ATOM 1181  C CG  . LEU A 1 160 ? 16.527  -2.956  -9.963  1.00 59.67  ? 154 LEU A CG  1 
ATOM 1182  C CD1 . LEU A 1 160 ? 17.070  -1.612  -9.522  1.00 59.70  ? 154 LEU A CD1 1 
ATOM 1183  C CD2 . LEU A 1 160 ? 17.558  -3.702  -10.780 1.00 61.13  ? 154 LEU A CD2 1 
ATOM 1184  N N   . LEU A 1 161 ? 13.241  -4.028  -7.736  1.00 53.69  ? 155 LEU A N   1 
ATOM 1185  C CA  . LEU A 1 161 ? 11.818  -3.894  -8.004  1.00 57.28  ? 155 LEU A CA  1 
ATOM 1186  C C   . LEU A 1 161 ? 11.241  -2.751  -7.177  1.00 64.29  ? 155 LEU A C   1 
ATOM 1187  O O   . LEU A 1 161 ? 10.253  -2.136  -7.579  1.00 67.97  ? 155 LEU A O   1 
ATOM 1188  C CB  . LEU A 1 161 ? 11.063  -5.171  -7.683  1.00 55.42  ? 155 LEU A CB  1 
ATOM 1189  C CG  . LEU A 1 161 ? 11.486  -6.396  -8.476  1.00 58.77  ? 155 LEU A CG  1 
ATOM 1190  C CD1 . LEU A 1 161 ? 10.576  -7.543  -8.093  1.00 58.29  ? 155 LEU A CD1 1 
ATOM 1191  C CD2 . LEU A 1 161 ? 11.437  -6.069  -9.955  1.00 62.07  ? 155 LEU A CD2 1 
ATOM 1192  N N   . PHE A 1 162 ? 11.897  -2.401  -6.073  1.00 64.43  ? 156 PHE A N   1 
ATOM 1193  C CA  . PHE A 1 162 ? 11.339  -1.364  -5.160  1.00 68.20  ? 156 PHE A CA  1 
ATOM 1194  C C   . PHE A 1 162 ? 11.841  0.017   -5.535  1.00 68.81  ? 156 PHE A C   1 
ATOM 1195  O O   . PHE A 1 162 ? 11.080  0.988   -5.449  1.00 72.40  ? 156 PHE A O   1 
ATOM 1196  C CB  . PHE A 1 162 ? 11.734  -1.633  -3.707  1.00 65.75  ? 156 PHE A CB  1 
ATOM 1197  C CG  . PHE A 1 162 ? 11.200  -0.632  -2.697  1.00 63.30  ? 156 PHE A CG  1 
ATOM 1198  C CD1 . PHE A 1 162 ? 9.836   -0.410  -2.567  1.00 59.83  ? 156 PHE A CD1 1 
ATOM 1199  C CD2 . PHE A 1 162 ? 12.065  0.083   -1.881  1.00 64.56  ? 156 PHE A CD2 1 
ATOM 1200  C CE1 . PHE A 1 162 ? 9.354   0.503   -1.648  1.00 54.79  ? 156 PHE A CE1 1 
ATOM 1201  C CE2 . PHE A 1 162 ? 11.575  0.992   -0.963  1.00 63.52  ? 156 PHE A CE2 1 
ATOM 1202  C CZ  . PHE A 1 162 ? 10.224  1.199   -0.849  1.00 61.78  ? 156 PHE A CZ  1 
ATOM 1203  N N   . PHE A 1 163 ? 13.065  0.102   -6.031  1.00 58.14  ? 157 PHE A N   1 
ATOM 1204  C CA  . PHE A 1 163 ? 13.653  1.412   -6.375  1.00 52.15  ? 157 PHE A CA  1 
ATOM 1205  C C   . PHE A 1 163 ? 12.762  1.944   -7.446  1.00 52.22  ? 157 PHE A C   1 
ATOM 1206  O O   . PHE A 1 163 ? 12.504  3.146   -7.483  1.00 55.47  ? 157 PHE A O   1 
ATOM 1207  C CB  . PHE A 1 163 ? 15.095  1.223   -6.829  1.00 49.49  ? 157 PHE A CB  1 
ATOM 1208  C CG  . PHE A 1 163 ? 16.162  1.467   -5.776  1.00 51.60  ? 157 PHE A CG  1 
ATOM 1209  C CD1 . PHE A 1 163 ? 16.267  0.646   -4.664  1.00 59.95  ? 157 PHE A CD1 1 
ATOM 1210  C CD2 . PHE A 1 163 ? 17.069  2.507   -5.912  1.00 59.17  ? 157 PHE A CD2 1 
ATOM 1211  C CE1 . PHE A 1 163 ? 17.248  0.868   -3.714  1.00 68.93  ? 157 PHE A CE1 1 
ATOM 1212  C CE2 . PHE A 1 163 ? 18.043  2.725   -4.957  1.00 63.86  ? 157 PHE A CE2 1 
ATOM 1213  C CZ  . PHE A 1 163 ? 18.130  1.907   -3.861  1.00 65.05  ? 157 PHE A CZ  1 
ATOM 1214  N N   . ALA A 1 164 ? 12.324  1.066   -8.331  1.00 55.10  ? 158 ALA A N   1 
ATOM 1215  C CA  . ALA A 1 164 ? 11.425  1.455   -9.433  1.00 58.46  ? 158 ALA A CA  1 
ATOM 1216  C C   . ALA A 1 164 ? 10.108  1.978   -8.881  1.00 58.83  ? 158 ALA A C   1 
ATOM 1217  O O   . ALA A 1 164 ? 9.539   2.898   -9.477  1.00 56.80  ? 158 ALA A O   1 
ATOM 1218  C CB  . ALA A 1 164 ? 11.169  0.261   -10.291 1.00 60.65  ? 158 ALA A CB  1 
ATOM 1219  N N   . LYS A 1 165 ? 9.592   1.349   -7.837  1.00 59.59  ? 159 LYS A N   1 
ATOM 1220  C CA  . LYS A 1 165 ? 8.364   1.868   -7.201  1.00 61.00  ? 159 LYS A CA  1 
ATOM 1221  C C   . LYS A 1 165 ? 8.646   3.273   -6.673  1.00 59.42  ? 159 LYS A C   1 
ATOM 1222  O O   . LYS A 1 165 ? 7.758   4.127   -6.772  1.00 55.78  ? 159 LYS A O   1 
ATOM 1223  C CB  . LYS A 1 165 ? 8.010   0.877   -6.100  1.00 63.13  ? 159 LYS A CB  1 
ATOM 1224  C CG  . LYS A 1 165 ? 7.636   -0.508  -6.596  1.00 71.22  ? 159 LYS A CG  1 
ATOM 1225  C CD  . LYS A 1 165 ? 6.468   -0.500  -7.572  1.00 74.80  ? 159 LYS A CD  1 
ATOM 1226  C CE  . LYS A 1 165 ? 6.015   -1.878  -7.926  1.00 74.45  ? 159 LYS A CE  1 
ATOM 1227  N NZ  . LYS A 1 165 ? 6.846   -2.457  -8.984  1.00 78.39  ? 159 LYS A NZ  1 
ATOM 1228  N N   . ARG A 1 166 ? 9.849   3.499   -6.164  1.00 59.76  ? 160 ARG A N   1 
ATOM 1229  C CA  . ARG A 1 166 ? 10.233  4.795   -5.610  1.00 62.23  ? 160 ARG A CA  1 
ATOM 1230  C C   . ARG A 1 166 ? 10.606  5.802   -6.700  1.00 62.38  ? 160 ARG A C   1 
ATOM 1231  O O   . ARG A 1 166 ? 10.797  6.979   -6.407  1.00 57.48  ? 160 ARG A O   1 
ATOM 1232  C CB  . ARG A 1 166 ? 11.384  4.668   -4.608  1.00 63.11  ? 160 ARG A CB  1 
ATOM 1233  C CG  . ARG A 1 166 ? 10.908  4.468   -3.175  1.00 65.48  ? 160 ARG A CG  1 
ATOM 1234  C CD  . ARG A 1 166 ? 12.062  4.664   -2.219  1.00 69.71  ? 160 ARG A CD  1 
ATOM 1235  N NE  . ARG A 1 166 ? 13.132  3.688   -2.451  1.00 71.88  ? 160 ARG A NE  1 
ATOM 1236  C CZ  . ARG A 1 166 ? 14.442  3.924   -2.341  1.00 76.39  ? 160 ARG A CZ  1 
ATOM 1237  N NH1 . ARG A 1 166 ? 14.907  5.149   -2.181  1.00 72.53  ? 160 ARG A NH1 1 
ATOM 1238  N NH2 . ARG A 1 166 ? 15.302  2.924   -2.393  1.00 81.23  ? 160 ARG A NH2 1 
ATOM 1239  N N   . TYR A 1 167 ? 10.737  5.324   -7.943  1.00 72.18  ? 161 TYR A N   1 
ATOM 1240  C CA  . TYR A 1 167 ? 10.789  6.157   -9.141  1.00 68.72  ? 161 TYR A CA  1 
ATOM 1241  C C   . TYR A 1 167 ? 9.364   6.599   -9.466  1.00 64.43  ? 161 TYR A C   1 
ATOM 1242  O O   . TYR A 1 167 ? 9.058   7.785   -9.418  1.00 66.17  ? 161 TYR A O   1 
ATOM 1243  C CB  . TYR A 1 167 ? 11.421  5.328   -10.272 1.00 66.27  ? 161 TYR A CB  1 
ATOM 1244  C CG  . TYR A 1 167 ? 11.893  6.023   -11.545 1.00 65.92  ? 161 TYR A CG  1 
ATOM 1245  C CD1 . TYR A 1 167 ? 12.744  7.125   -11.506 1.00 72.44  ? 161 TYR A CD1 1 
ATOM 1246  C CD2 . TYR A 1 167 ? 11.526  5.541   -12.801 1.00 64.20  ? 161 TYR A CD2 1 
ATOM 1247  C CE1 . TYR A 1 167 ? 13.195  7.737   -12.669 1.00 72.30  ? 161 TYR A CE1 1 
ATOM 1248  C CE2 . TYR A 1 167 ? 11.968  6.142   -13.971 1.00 64.65  ? 161 TYR A CE2 1 
ATOM 1249  C CZ  . TYR A 1 167 ? 12.809  7.242   -13.906 1.00 69.51  ? 161 TYR A CZ  1 
ATOM 1250  O OH  . TYR A 1 167 ? 13.242  7.828   -15.063 1.00 67.67  ? 161 TYR A OH  1 
ATOM 1251  N N   . LYS A 1 168 ? 8.495   5.614   -9.735  1.00 60.77  ? 162 LYS A N   1 
ATOM 1252  C CA  . LYS A 1 168 ? 7.125   5.846   -10.161 1.00 59.27  ? 162 LYS A CA  1 
ATOM 1253  C C   . LYS A 1 168 ? 6.431   6.779   -9.184  1.00 54.08  ? 162 LYS A C   1 
ATOM 1254  O O   . LYS A 1 168 ? 5.504   7.490   -9.573  1.00 49.02  ? 162 LYS A O   1 
ATOM 1255  C CB  . LYS A 1 168 ? 6.352   4.523   -10.207 1.00 66.01  ? 162 LYS A CB  1 
ATOM 1256  C CG  . LYS A 1 168 ? 4.861   4.595   -10.541 1.00 69.40  ? 162 LYS A CG  1 
ATOM 1257  C CD  . LYS A 1 168 ? 4.208   3.223   -10.420 1.00 74.94  ? 162 LYS A CD  1 
ATOM 1258  C CE  . LYS A 1 168 ? 2.875   3.131   -11.080 1.00 80.64  ? 162 LYS A CE  1 
ATOM 1259  N NZ  . LYS A 1 168 ? 2.622   1.773   -11.569 1.00 84.74  ? 162 LYS A NZ  1 
ATOM 1260  N N   . ALA A 1 169 ? 6.874   6.716   -7.919  1.00 53.35  ? 163 ALA A N   1 
ATOM 1261  C CA  . ALA A 1 169 ? 6.359   7.563   -6.856  1.00 56.71  ? 163 ALA A CA  1 
ATOM 1262  C C   . ALA A 1 169 ? 6.834   9.006   -7.024  1.00 61.92  ? 163 ALA A C   1 
ATOM 1263  O O   . ALA A 1 169 ? 6.065   9.935   -6.785  1.00 71.27  ? 163 ALA A O   1 
ATOM 1264  C CB  . ALA A 1 169 ? 6.776   7.007   -5.517  1.00 53.72  ? 163 ALA A CB  1 
ATOM 1265  N N   . ALA A 1 170 ? 8.106   9.155   -7.338  1.00 61.96  ? 164 ALA A N   1 
ATOM 1266  C CA  . ALA A 1 170 ? 8.664   10.507  -7.447  1.00 66.55  ? 164 ALA A CA  1 
ATOM 1267  C C   . ALA A 1 170 ? 7.931   11.206  -8.576  1.00 73.87  ? 164 ALA A C   1 
ATOM 1268  O O   . ALA A 1 170 ? 7.485   12.357  -8.440  1.00 74.32  ? 164 ALA A O   1 
ATOM 1269  C CB  . ALA A 1 170 ? 10.131  10.397  -7.724  1.00 62.22  ? 164 ALA A CB  1 
ATOM 1270  N N   . PHE A 1 171 ? 7.861   10.519  -9.700  1.00 73.20  ? 165 PHE A N   1 
ATOM 1271  C CA  . PHE A 1 171 ? 7.227   11.169  -10.860 1.00 78.54  ? 165 PHE A CA  1 
ATOM 1272  C C   . PHE A 1 171 ? 5.785   11.453  -10.560 1.00 76.71  ? 165 PHE A C   1 
ATOM 1273  O O   . PHE A 1 171 ? 5.292   12.510  -10.971 1.00 77.22  ? 165 PHE A O   1 
ATOM 1274  C CB  . PHE A 1 171 ? 7.405   10.226  -12.050 1.00 78.99  ? 165 PHE A CB  1 
ATOM 1275  C CG  . PHE A 1 171 ? 8.714   10.457  -12.784 1.00 75.83  ? 165 PHE A CG  1 
ATOM 1276  C CD1 . PHE A 1 171 ? 8.896   11.587  -13.567 1.00 81.99  ? 165 PHE A CD1 1 
ATOM 1277  C CD2 . PHE A 1 171 ? 9.765   9.563   -12.661 1.00 67.71  ? 165 PHE A CD2 1 
ATOM 1278  C CE1 . PHE A 1 171 ? 10.094  11.809  -14.219 1.00 77.13  ? 165 PHE A CE1 1 
ATOM 1279  C CE2 . PHE A 1 171 ? 10.959  9.795   -13.314 1.00 65.44  ? 165 PHE A CE2 1 
ATOM 1280  C CZ  . PHE A 1 171 ? 11.121  10.911  -14.091 1.00 69.19  ? 165 PHE A CZ  1 
ATOM 1281  N N   . THR A 1 172 ? 5.080   10.524  -9.926  1.00 73.69  ? 166 THR A N   1 
ATOM 1282  C CA  . THR A 1 172 ? 3.683   10.906  -9.725  1.00 70.74  ? 166 THR A CA  1 
ATOM 1283  C C   . THR A 1 172 ? 3.553   12.109  -8.830  1.00 70.95  ? 166 THR A C   1 
ATOM 1284  O O   . THR A 1 172 ? 2.752   12.984  -9.181  1.00 76.30  ? 166 THR A O   1 
ATOM 1285  C CB  . THR A 1 172 ? 2.954   9.724   -9.081  1.00 63.04  ? 166 THR A CB  1 
ATOM 1286  O OG1 . THR A 1 172 ? 3.917   8.985   -8.340  1.00 51.72  ? 166 THR A OG1 1 
ATOM 1287  C CG2 . THR A 1 172 ? 2.303   8.805   -10.097 1.00 62.40  ? 166 THR A CG2 1 
ATOM 1288  N N   . GLU A 1 173 ? 4.272   12.182  -7.702  1.00 66.56  ? 167 GLU A N   1 
ATOM 1289  C CA  . GLU A 1 173 ? 4.172   13.438  -6.912  1.00 70.83  ? 167 GLU A CA  1 
ATOM 1290  C C   . GLU A 1 173 ? 4.746   14.700  -7.565  1.00 69.30  ? 167 GLU A C   1 
ATOM 1291  O O   . GLU A 1 173 ? 4.059   15.725  -7.600  1.00 63.91  ? 167 GLU A O   1 
ATOM 1292  C CB  . GLU A 1 173 ? 4.921   13.229  -5.595  1.00 63.10  ? 167 GLU A CB  1 
ATOM 1293  C CG  . GLU A 1 173 ? 5.323   14.529  -4.909  1.00 63.55  ? 167 GLU A CG  1 
ATOM 1294  C CD  . GLU A 1 173 ? 5.415   14.383  -3.406  1.00 71.07  ? 167 GLU A CD  1 
ATOM 1295  O OE1 . GLU A 1 173 ? 5.432   13.231  -2.935  1.00 77.19  ? 167 GLU A OE1 1 
ATOM 1296  O OE2 . GLU A 1 173 ? 5.469   15.415  -2.710  1.00 79.00  ? 167 GLU A OE2 1 
ATOM 1297  N N   . CYS A 1 174 ? 5.937   14.577  -8.136  1.00 67.23  ? 168 CYS A N   1 
ATOM 1298  C CA  . CYS A 1 174 ? 6.597   15.790  -8.689  1.00 70.30  ? 168 CYS A CA  1 
ATOM 1299  C C   . CYS A 1 174 ? 5.812   16.339  -9.891  1.00 68.77  ? 168 CYS A C   1 
ATOM 1300  O O   . CYS A 1 174 ? 5.682   17.563  -10.005 1.00 69.97  ? 168 CYS A O   1 
ATOM 1301  C CB  . CYS A 1 174 ? 8.120   15.647  -8.632  1.00 77.10  ? 168 CYS A CB  1 
ATOM 1302  S SG  . CYS A 1 174 ? 8.747   16.216  -7.022  1.00 86.67  ? 168 CYS A SG  1 
ATOM 1303  N N   . CYS A 1 175 ? 5.317   15.452  -10.743 1.00 72.84  ? 169 CYS A N   1 
ATOM 1304  C CA  . CYS A 1 175 ? 4.643   15.919  -11.976 1.00 76.13  ? 169 CYS A CA  1 
ATOM 1305  C C   . CYS A 1 175 ? 3.225   16.372  -11.610 1.00 79.49  ? 169 CYS A C   1 
ATOM 1306  O O   . CYS A 1 175 ? 2.507   16.768  -12.540 1.00 78.94  ? 169 CYS A O   1 
ATOM 1307  C CB  . CYS A 1 175 ? 4.621   14.836  -13.053 1.00 79.08  ? 169 CYS A CB  1 
ATOM 1308  S SG  . CYS A 1 175 ? 6.215   14.093  -13.511 1.00 89.19  ? 169 CYS A SG  1 
ATOM 1309  N N   . ALA A 1 182 ? 8.304   23.784  -9.255  1.00 111.46 ? 176 ALA A N   1 
ATOM 1310  C CA  . ALA A 1 182 ? 9.234   23.495  -8.136  1.00 101.58 ? 176 ALA A CA  1 
ATOM 1311  C C   . ALA A 1 182 ? 9.745   22.060  -8.257  1.00 113.82 ? 176 ALA A C   1 
ATOM 1312  O O   . ALA A 1 182 ? 9.688   21.525  -9.389  1.00 101.05 ? 176 ALA A O   1 
ATOM 1313  C CB  . ALA A 1 182 ? 8.580   23.760  -6.794  1.00 89.13  ? 176 ALA A CB  1 
ATOM 1314  N N   . CYS A 1 183 ? 10.229  21.457  -7.153  1.00 115.81 ? 177 CYS A N   1 
ATOM 1315  C CA  . CYS A 1 183 ? 10.808  20.101  -7.350  1.00 103.26 ? 177 CYS A CA  1 
ATOM 1316  C C   . CYS A 1 183 ? 11.989  20.285  -8.298  1.00 112.63 ? 177 CYS A C   1 
ATOM 1317  O O   . CYS A 1 183 ? 12.835  21.115  -7.908  1.00 83.98  ? 177 CYS A O   1 
ATOM 1318  C CB  . CYS A 1 183 ? 9.794   19.018  -7.696  1.00 90.63  ? 177 CYS A CB  1 
ATOM 1319  S SG  . CYS A 1 183 ? 10.414  17.352  -7.333  1.00 68.72  ? 177 CYS A SG  1 
ATOM 1320  N N   . LEU A 1 185 ? 13.133  17.292  -9.073  1.00 104.46 ? 179 LEU A N   1 
ATOM 1321  C CA  . LEU A 1 185 ? 13.544  15.875  -8.859  1.00 80.83  ? 179 LEU A CA  1 
ATOM 1322  C C   . LEU A 1 185 ? 14.974  15.662  -8.334  1.00 82.92  ? 179 LEU A C   1 
ATOM 1323  O O   . LEU A 1 185 ? 15.728  14.880  -8.921  1.00 73.08  ? 179 LEU A O   1 
ATOM 1324  C CB  . LEU A 1 185 ? 13.187  15.081  -10.106 1.00 80.21  ? 179 LEU A CB  1 
ATOM 1325  C CG  . LEU A 1 185 ? 11.686  14.922  -10.370 1.00 82.04  ? 179 LEU A CG  1 
ATOM 1326  C CD1 . LEU A 1 185 ? 11.388  14.742  -11.844 1.00 73.89  ? 179 LEU A CD1 1 
ATOM 1327  C CD2 . LEU A 1 185 ? 11.118  13.763  -9.582  1.00 84.31  ? 179 LEU A CD2 1 
ATOM 1328  N N   . PRO A 1 186 ? 15.378  16.372  -7.272  1.00 81.51  ? 180 PRO A N   1 
ATOM 1329  C CA  . PRO A 1 186 ? 16.666  16.210  -6.620  1.00 77.63  ? 180 PRO A CA  1 
ATOM 1330  C C   . PRO A 1 186 ? 16.535  14.762  -6.198  1.00 78.45  ? 180 PRO A C   1 
ATOM 1331  O O   . PRO A 1 186 ? 17.549  14.059  -6.198  1.00 78.58  ? 180 PRO A O   1 
ATOM 1332  C CB  . PRO A 1 186 ? 16.634  17.185  -5.470  1.00 73.69  ? 180 PRO A CB  1 
ATOM 1333  C CG  . PRO A 1 186 ? 15.173  17.413  -5.212  1.00 71.20  ? 180 PRO A CG  1 
ATOM 1334  C CD  . PRO A 1 186 ? 14.586  17.388  -6.599  1.00 72.91  ? 180 PRO A CD  1 
ATOM 1335  N N   . LYS A 1 187 ? 15.350  14.304  -5.827  1.00 71.44  ? 181 LYS A N   1 
ATOM 1336  C CA  . LYS A 1 187 ? 15.097  12.950  -5.292  1.00 65.36  ? 181 LYS A CA  1 
ATOM 1337  C C   . LYS A 1 187 ? 15.514  11.912  -6.339  1.00 64.15  ? 181 LYS A C   1 
ATOM 1338  O O   . LYS A 1 187 ? 16.017  10.859  -5.932  1.00 61.97  ? 181 LYS A O   1 
ATOM 1339  C CB  . LYS A 1 187 ? 13.590  12.814  -5.095  1.00 64.58  ? 181 LYS A CB  1 
ATOM 1340  C CG  . LYS A 1 187 ? 12.728  13.746  -5.918  1.00 67.17  ? 181 LYS A CG  1 
ATOM 1341  C CD  . LYS A 1 187 ? 11.252  13.378  -5.844  1.00 69.24  ? 181 LYS A CD  1 
ATOM 1342  C CE  . LYS A 1 187 ? 10.809  12.996  -4.473  1.00 67.95  ? 181 LYS A CE  1 
ATOM 1343  N NZ  . LYS A 1 187 ? 9.367   13.192  -4.313  1.00 72.14  ? 181 LYS A NZ  1 
ATOM 1344  N N   . LEU A 1 188 ? 15.303  12.153  -7.619  1.00 56.18  ? 182 LEU A N   1 
ATOM 1345  C CA  . LEU A 1 188 ? 15.770  11.149  -8.595  1.00 59.70  ? 182 LEU A CA  1 
ATOM 1346  C C   . LEU A 1 188 ? 17.289  11.025  -8.448  1.00 68.79  ? 182 LEU A C   1 
ATOM 1347  O O   . LEU A 1 188 ? 17.789  9.902   -8.567  1.00 83.86  ? 182 LEU A O   1 
ATOM 1348  C CB  . LEU A 1 188 ? 15.439  11.614  -10.006 1.00 57.80  ? 182 LEU A CB  1 
ATOM 1349  C CG  . LEU A 1 188 ? 13.982  11.485  -10.448 1.00 59.82  ? 182 LEU A CG  1 
ATOM 1350  C CD1 . LEU A 1 188 ? 13.926  11.611  -11.955 1.00 58.56  ? 182 LEU A CD1 1 
ATOM 1351  C CD2 . LEU A 1 188 ? 13.418  10.157  -9.995  1.00 63.29  ? 182 LEU A CD2 1 
ATOM 1352  N N   . ASP A 1 189 ? 18.004  12.122  -8.241  1.00 68.02  ? 183 ASP A N   1 
ATOM 1353  C CA  . ASP A 1 189 ? 19.478  12.074  -8.065  1.00 69.73  ? 183 ASP A CA  1 
ATOM 1354  C C   . ASP A 1 189 ? 19.841  11.267  -6.821  1.00 67.17  ? 183 ASP A C   1 
ATOM 1355  O O   . ASP A 1 189 ? 20.827  10.530  -6.862  1.00 66.97  ? 183 ASP A O   1 
ATOM 1356  C CB  . ASP A 1 189 ? 20.065  13.466  -7.960  1.00 77.59  ? 183 ASP A CB  1 
ATOM 1357  C CG  . ASP A 1 189 ? 20.446  14.126  -9.274  1.00 88.08  ? 183 ASP A CG  1 
ATOM 1358  O OD1 . ASP A 1 189 ? 20.160  13.534  -10.328 1.00 82.03  ? 183 ASP A OD1 1 
ATOM 1359  O OD2 . ASP A 1 189 ? 21.028  15.227  -9.227  1.00 103.46 ? 183 ASP A OD2 1 
ATOM 1360  N N   . GLU A 1 190 ? 19.098  11.424  -5.742  1.00 72.29  ? 184 GLU A N   1 
ATOM 1361  C CA  . GLU A 1 190 ? 19.334  10.617  -4.521  1.00 79.54  ? 184 GLU A CA  1 
ATOM 1362  C C   . GLU A 1 190 ? 19.099  9.136   -4.811  1.00 67.85  ? 184 GLU A C   1 
ATOM 1363  O O   . GLU A 1 190 ? 19.873  8.309   -4.322  1.00 72.15  ? 184 GLU A O   1 
ATOM 1364  C CB  . GLU A 1 190 ? 18.400  11.057  -3.399  1.00 92.77  ? 184 GLU A CB  1 
ATOM 1365  C CG  . GLU A 1 190 ? 18.192  12.568  -3.342  1.00 106.80 ? 184 GLU A CG  1 
ATOM 1366  C CD  . GLU A 1 190 ? 19.409  13.405  -2.986  1.00 107.95 ? 184 GLU A CD  1 
ATOM 1367  O OE1 . GLU A 1 190 ? 20.360  12.861  -2.386  1.00 108.21 ? 184 GLU A OE1 1 
ATOM 1368  O OE2 . GLU A 1 190 ? 19.401  14.610  -3.309  1.00 92.37  ? 184 GLU A OE2 1 
ATOM 1369  N N   . LEU A 1 191 ? 18.076  8.818   -5.587  1.00 59.96  ? 185 LEU A N   1 
ATOM 1370  C CA  . LEU A 1 191 ? 17.746  7.400   -5.838  1.00 59.37  ? 185 LEU A CA  1 
ATOM 1371  C C   . LEU A 1 191 ? 18.954  6.813   -6.542  1.00 61.61  ? 185 LEU A C   1 
ATOM 1372  O O   . LEU A 1 191 ? 19.288  5.657   -6.279  1.00 65.12  ? 185 LEU A O   1 
ATOM 1373  C CB  . LEU A 1 191 ? 16.516  7.275   -6.725  1.00 62.77  ? 185 LEU A CB  1 
ATOM 1374  C CG  . LEU A 1 191 ? 15.196  6.908   -6.047  1.00 66.37  ? 185 LEU A CG  1 
ATOM 1375  C CD1 . LEU A 1 191 ? 14.128  6.887   -7.120  1.00 65.65  ? 185 LEU A CD1 1 
ATOM 1376  C CD2 . LEU A 1 191 ? 15.308  5.551   -5.394  1.00 68.81  ? 185 LEU A CD2 1 
ATOM 1377  N N   . ARG A 1 192 ? 19.538  7.583   -7.448  1.00 65.35  ? 186 ARG A N   1 
ATOM 1378  C CA  . ARG A 1 192 ? 20.718  7.087   -8.183  1.00 65.04  ? 186 ARG A CA  1 
ATOM 1379  C C   . ARG A 1 192 ? 21.861  6.823   -7.203  1.00 63.54  ? 186 ARG A C   1 
ATOM 1380  O O   . ARG A 1 192 ? 22.502  5.770   -7.316  1.00 56.75  ? 186 ARG A O   1 
ATOM 1381  C CB  . ARG A 1 192 ? 21.142  8.182   -9.162  1.00 61.27  ? 186 ARG A CB  1 
ATOM 1382  C CG  . ARG A 1 192 ? 22.642  8.359   -9.335  1.00 68.25  ? 186 ARG A CG  1 
ATOM 1383  C CD  . ARG A 1 192 ? 22.957  9.286   -10.490 1.00 79.29  ? 186 ARG A CD  1 
ATOM 1384  N NE  . ARG A 1 192 ? 22.802  10.694  -10.115 1.00 81.60  ? 186 ARG A NE  1 
ATOM 1385  C CZ  . ARG A 1 192 ? 23.388  11.707  -10.735 1.00 82.54  ? 186 ARG A CZ  1 
ATOM 1386  N NH1 . ARG A 1 192 ? 23.704  11.610  -12.012 1.00 79.92  ? 186 ARG A NH1 1 
ATOM 1387  N NH2 . ARG A 1 192 ? 23.655  12.817  -10.075 1.00 91.99  ? 186 ARG A NH2 1 
ATOM 1388  N N   . ASP A 1 193 ? 22.056  7.717   -6.244  1.00 59.99  ? 187 ASP A N   1 
ATOM 1389  C CA  . ASP A 1 193 ? 23.151  7.540   -5.263  1.00 62.39  ? 187 ASP A CA  1 
ATOM 1390  C C   . ASP A 1 193 ? 22.945  6.287   -4.409  1.00 60.31  ? 187 ASP A C   1 
ATOM 1391  O O   . ASP A 1 193 ? 23.932  5.576   -4.160  1.00 60.88  ? 187 ASP A O   1 
ATOM 1392  C CB  . ASP A 1 193 ? 23.318  8.811   -4.454  1.00 69.48  ? 187 ASP A CB  1 
ATOM 1393  C CG  . ASP A 1 193 ? 23.830  10.014  -5.229  1.00 76.91  ? 187 ASP A CG  1 
ATOM 1394  O OD1 . ASP A 1 193 ? 23.761  9.979   -6.470  1.00 73.32  ? 187 ASP A OD1 1 
ATOM 1395  O OD2 . ASP A 1 193 ? 24.294  10.973  -4.583  1.00 86.98  ? 187 ASP A OD2 1 
ATOM 1396  N N   . GLU A 1 194 ? 21.721  6.030   -3.968  1.00 57.03  ? 188 GLU A N   1 
ATOM 1397  C CA  . GLU A 1 194 ? 21.412  4.805   -3.191  1.00 61.77  ? 188 GLU A CA  1 
ATOM 1398  C C   . GLU A 1 194 ? 21.644  3.559   -4.048  1.00 61.15  ? 188 GLU A C   1 
ATOM 1399  O O   . GLU A 1 194 ? 22.114  2.552   -3.511  1.00 61.71  ? 188 GLU A O   1 
ATOM 1400  C CB  . GLU A 1 194 ? 19.982  4.890   -2.673  1.00 71.97  ? 188 GLU A CB  1 
ATOM 1401  C CG  . GLU A 1 194 ? 19.843  5.589   -1.326  1.00 81.69  ? 188 GLU A CG  1 
ATOM 1402  C CD  . GLU A 1 194 ? 18.416  5.502   -0.818  1.00 95.46  ? 188 GLU A CD  1 
ATOM 1403  O OE1 . GLU A 1 194 ? 17.800  4.429   -0.982  1.00 86.95  ? 188 GLU A OE1 1 
ATOM 1404  O OE2 . GLU A 1 194 ? 17.916  6.502   -0.266  1.00 117.60 ? 188 GLU A OE2 1 
ATOM 1405  N N   . GLY A 1 195 ? 21.262  3.614   -5.317  1.00 59.03  ? 189 GLY A N   1 
ATOM 1406  C CA  . GLY A 1 195 ? 21.412  2.472   -6.225  1.00 57.71  ? 189 GLY A CA  1 
ATOM 1407  C C   . GLY A 1 195 ? 22.864  2.132   -6.397  1.00 63.12  ? 189 GLY A C   1 
ATOM 1408  O O   . GLY A 1 195 ? 23.196  0.945   -6.445  1.00 61.83  ? 189 GLY A O   1 
ATOM 1409  N N   . LYS A 1 196 ? 23.704  3.146   -6.497  1.00 67.37  ? 190 LYS A N   1 
ATOM 1410  C CA  . LYS A 1 196 ? 25.134  2.898   -6.747  1.00 63.28  ? 190 LYS A CA  1 
ATOM 1411  C C   . LYS A 1 196 ? 25.627  2.117   -5.551  1.00 59.33  ? 190 LYS A C   1 
ATOM 1412  O O   . LYS A 1 196 ? 26.428  1.199   -5.738  1.00 61.07  ? 190 LYS A O   1 
ATOM 1413  C CB  . LYS A 1 196 ? 25.870  4.232   -6.833  1.00 73.29  ? 190 LYS A CB  1 
ATOM 1414  C CG  . LYS A 1 196 ? 25.484  5.131   -7.998  1.00 85.03  ? 190 LYS A CG  1 
ATOM 1415  C CD  . LYS A 1 196 ? 25.241  4.379   -9.300  1.00 96.22  ? 190 LYS A CD  1 
ATOM 1416  C CE  . LYS A 1 196 ? 24.216  5.027   -10.176 1.00 107.43 ? 190 LYS A CE  1 
ATOM 1417  N NZ  . LYS A 1 196 ? 22.868  4.506   -9.931  1.00 111.89 ? 190 LYS A NZ  1 
ATOM 1418  N N   . ALA A 1 197 ? 25.162  2.496   -4.371  1.00 60.57  ? 191 ALA A N   1 
ATOM 1419  C CA  . ALA A 1 197 ? 25.586  1.816   -3.131  1.00 62.29  ? 191 ALA A CA  1 
ATOM 1420  C C   . ALA A 1 197 ? 24.998  0.408   -3.052  1.00 63.04  ? 191 ALA A C   1 
ATOM 1421  O O   . ALA A 1 197 ? 25.757  -0.554  -2.905  1.00 57.66  ? 191 ALA A O   1 
ATOM 1422  C CB  . ALA A 1 197 ? 25.171  2.653   -1.964  1.00 59.46  ? 191 ALA A CB  1 
ATOM 1423  N N   . SER A 1 198 ? 23.679  0.292   -3.123  1.00 64.27  ? 192 SER A N   1 
ATOM 1424  C CA  . SER A 1 198 ? 23.077  -1.034  -2.989  1.00 69.72  ? 192 SER A CA  1 
ATOM 1425  C C   . SER A 1 198 ? 23.477  -1.949  -4.152  1.00 72.69  ? 192 SER A C   1 
ATOM 1426  O O   . SER A 1 198 ? 23.169  -3.146  -4.161  1.00 70.99  ? 192 SER A O   1 
ATOM 1427  C CB  . SER A 1 198 ? 21.569  -0.963  -2.894  1.00 70.42  ? 192 SER A CB  1 
ATOM 1428  O OG  . SER A 1 198 ? 20.978  -1.140  -4.177  1.00 72.64  ? 192 SER A OG  1 
ATOM 1429  N N   . SER A 1 199 ? 24.089  -1.355  -5.179  1.00 69.03  ? 193 SER A N   1 
ATOM 1430  C CA  . SER A 1 199 ? 24.785  -2.124  -6.186  1.00 70.33  ? 193 SER A CA  1 
ATOM 1431  C C   . SER A 1 199 ? 26.116  -2.621  -5.615  1.00 70.44  ? 193 SER A C   1 
ATOM 1432  O O   . SER A 1 199 ? 26.365  -3.828  -5.513  1.00 62.12  ? 193 SER A O   1 
ATOM 1433  C CB  . SER A 1 199 ? 24.970  -1.297  -7.421  1.00 70.29  ? 193 SER A CB  1 
ATOM 1434  O OG  . SER A 1 199 ? 25.749  -1.990  -8.385  1.00 85.78  ? 193 SER A OG  1 
ATOM 1435  N N   . ALA A 1 200 ? 26.993  -1.698  -5.271  1.00 65.92  ? 194 ALA A N   1 
ATOM 1436  C CA  . ALA A 1 200 ? 28.338  -2.134  -4.850  1.00 67.18  ? 194 ALA A CA  1 
ATOM 1437  C C   . ALA A 1 200 ? 28.256  -3.210  -3.785  1.00 68.39  ? 194 ALA A C   1 
ATOM 1438  O O   . ALA A 1 200 ? 29.080  -4.131  -3.813  1.00 67.54  ? 194 ALA A O   1 
ATOM 1439  C CB  . ALA A 1 200 ? 29.081  -0.958  -4.333  1.00 73.33  ? 194 ALA A CB  1 
ATOM 1440  N N   . LYS A 1 201 ? 27.368  -3.036  -2.818  1.00 78.79  ? 195 LYS A N   1 
ATOM 1441  C CA  . LYS A 1 201 ? 27.314  -4.000  -1.694  1.00 78.88  ? 195 LYS A CA  1 
ATOM 1442  C C   . LYS A 1 201 ? 26.932  -5.397  -2.195  1.00 75.75  ? 195 LYS A C   1 
ATOM 1443  O O   . LYS A 1 201 ? 27.540  -6.367  -1.730  1.00 78.46  ? 195 LYS A O   1 
ATOM 1444  C CB  . LYS A 1 201 ? 26.336  -3.445  -0.655  1.00 78.79  ? 195 LYS A CB  1 
ATOM 1445  C CG  . LYS A 1 201 ? 26.660  -2.058  -0.123  1.00 80.47  ? 195 LYS A CG  1 
ATOM 1446  C CD  . LYS A 1 201 ? 25.835  -1.650  1.091   1.00 87.05  ? 195 LYS A CD  1 
ATOM 1447  C CE  . LYS A 1 201 ? 24.447  -1.218  0.741   1.00 93.30  ? 195 LYS A CE  1 
ATOM 1448  N NZ  . LYS A 1 201 ? 23.982  -0.088  1.550   1.00 87.84  ? 195 LYS A NZ  1 
ATOM 1449  N N   . GLN A 1 202 ? 25.977  -5.496  -3.111  1.00 65.95  ? 196 GLN A N   1 
ATOM 1450  C CA  . GLN A 1 202 ? 25.533  -6.846  -3.542  1.00 62.03  ? 196 GLN A CA  1 
ATOM 1451  C C   . GLN A 1 202 ? 26.709  -7.553  -4.215  1.00 55.49  ? 196 GLN A C   1 
ATOM 1452  O O   . GLN A 1 202 ? 26.868  -8.752  -4.014  1.00 45.32  ? 196 GLN A O   1 
ATOM 1453  C CB  . GLN A 1 202 ? 24.246  -6.757  -4.360  1.00 61.77  ? 196 GLN A CB  1 
ATOM 1454  C CG  . GLN A 1 202 ? 23.420  -8.036  -4.406  1.00 54.10  ? 196 GLN A CG  1 
ATOM 1455  C CD  . GLN A 1 202 ? 23.130  -8.614  -3.044  1.00 52.39  ? 196 GLN A CD  1 
ATOM 1456  O OE1 . GLN A 1 202 ? 22.909  -7.894  -2.066  1.00 61.32  ? 196 GLN A OE1 1 
ATOM 1457  N NE2 . GLN A 1 202 ? 23.127  -9.934  -2.977  1.00 49.27  ? 196 GLN A NE2 1 
ATOM 1458  N N   . ARG A 1 203 ? 27.470  -6.824  -5.016  1.00 64.00  ? 197 ARG A N   1 
ATOM 1459  C CA  . ARG A 1 203 ? 28.654  -7.417  -5.680  1.00 65.96  ? 197 ARG A CA  1 
ATOM 1460  C C   . ARG A 1 203 ? 29.675  -7.857  -4.637  1.00 58.23  ? 197 ARG A C   1 
ATOM 1461  O O   . ARG A 1 203 ? 30.226  -8.954  -4.769  1.00 52.84  ? 197 ARG A O   1 
ATOM 1462  C CB  . ARG A 1 203 ? 29.327  -6.394  -6.597  1.00 65.89  ? 197 ARG A CB  1 
ATOM 1463  C CG  . ARG A 1 203 ? 30.643  -6.852  -7.206  1.00 74.61  ? 197 ARG A CG  1 
ATOM 1464  C CD  . ARG A 1 203 ? 30.481  -8.144  -7.985  1.00 85.76  ? 197 ARG A CD  1 
ATOM 1465  N NE  . ARG A 1 203 ? 31.762  -8.655  -8.481  1.00 91.80  ? 197 ARG A NE  1 
ATOM 1466  C CZ  . ARG A 1 203 ? 32.016  -9.933  -8.705  1.00 87.78  ? 197 ARG A CZ  1 
ATOM 1467  N NH1 . ARG A 1 203 ? 31.023  -10.784 -8.875  1.00 84.40  ? 197 ARG A NH1 1 
ATOM 1468  N NH2 . ARG A 1 203 ? 33.264  -10.357 -8.758  1.00 91.87  ? 197 ARG A NH2 1 
ATOM 1469  N N   . LEU A 1 204 ? 29.890  -7.049  -3.614  1.00 54.47  ? 198 LEU A N   1 
ATOM 1470  C CA  . LEU A 1 204 ? 30.821  -7.543  -2.591  1.00 56.90  ? 198 LEU A CA  1 
ATOM 1471  C C   . LEU A 1 204 ? 30.214  -8.789  -1.965  1.00 55.24  ? 198 LEU A C   1 
ATOM 1472  O O   . LEU A 1 204 ? 30.954  -9.742  -1.723  1.00 52.48  ? 198 LEU A O   1 
ATOM 1473  C CB  . LEU A 1 204 ? 31.030  -6.436  -1.569  1.00 60.28  ? 198 LEU A CB  1 
ATOM 1474  C CG  . LEU A 1 204 ? 32.401  -6.404  -0.889  1.00 66.53  ? 198 LEU A CG  1 
ATOM 1475  C CD1 . LEU A 1 204 ? 33.506  -6.574  -1.909  1.00 67.86  ? 198 LEU A CD1 1 
ATOM 1476  C CD2 . LEU A 1 204 ? 32.582  -5.111  -0.127  1.00 68.62  ? 198 LEU A CD2 1 
ATOM 1477  N N   . LYS A 1 205 ? 28.914  -8.767  -1.697  1.00 53.96  ? 199 LYS A N   1 
ATOM 1478  C CA  . LYS A 1 205 ? 28.377  -9.951  -1.008  1.00 55.42  ? 199 LYS A CA  1 
ATOM 1479  C C   . LYS A 1 205 ? 28.506  -11.198 -1.875  1.00 58.25  ? 199 LYS A C   1 
ATOM 1480  O O   . LYS A 1 205 ? 28.951  -12.232 -1.371  1.00 60.87  ? 199 LYS A O   1 
ATOM 1481  C CB  . LYS A 1 205 ? 26.890  -9.680  -0.791  1.00 59.37  ? 199 LYS A CB  1 
ATOM 1482  C CG  . LYS A 1 205 ? 26.562  -8.628  0.249   1.00 73.71  ? 199 LYS A CG  1 
ATOM 1483  C CD  . LYS A 1 205 ? 25.084  -8.571  0.609   1.00 85.16  ? 199 LYS A CD  1 
ATOM 1484  C CE  . LYS A 1 205 ? 24.705  -7.274  1.247   1.00 90.53  ? 199 LYS A CE  1 
ATOM 1485  N NZ  . LYS A 1 205 ? 23.644  -6.590  0.504   1.00 99.54  ? 199 LYS A NZ  1 
ATOM 1486  N N   . CYS A 1 206 ? 28.185  -11.067 -3.156  1.00 59.09  ? 200 CYS A N   1 
ATOM 1487  C CA  . CYS A 1 206 ? 28.240  -12.239 -4.050  1.00 57.54  ? 200 CYS A CA  1 
ATOM 1488  C C   . CYS A 1 206 ? 29.669  -12.740 -4.186  1.00 61.90  ? 200 CYS A C   1 
ATOM 1489  O O   . CYS A 1 206 ? 29.900  -13.949 -4.119  1.00 68.38  ? 200 CYS A O   1 
ATOM 1490  C CB  . CYS A 1 206 ? 27.676  -11.862 -5.410  1.00 56.65  ? 200 CYS A CB  1 
ATOM 1491  S SG  . CYS A 1 206 ? 25.873  -11.830 -5.414  1.00 53.41  ? 200 CYS A SG  1 
ATOM 1492  N N   . ALA A 1 207 ? 30.590  -11.804 -4.340  1.00 66.39  ? 201 ALA A N   1 
ATOM 1493  C CA  . ALA A 1 207 ? 32.000  -12.199 -4.467  1.00 68.62  ? 201 ALA A CA  1 
ATOM 1494  C C   . ALA A 1 207 ? 32.439  -12.852 -3.179  1.00 79.03  ? 201 ALA A C   1 
ATOM 1495  O O   . ALA A 1 207 ? 33.125  -13.877 -3.187  1.00 73.34  ? 201 ALA A O   1 
ATOM 1496  C CB  . ALA A 1 207 ? 32.827  -10.983 -4.716  1.00 67.84  ? 201 ALA A CB  1 
ATOM 1497  N N   . SER A 1 208 ? 32.009  -12.250 -2.083  1.00 95.61  ? 202 SER A N   1 
ATOM 1498  C CA  . SER A 1 208 ? 32.510  -12.759 -0.799  1.00 95.75  ? 202 SER A CA  1 
ATOM 1499  C C   . SER A 1 208 ? 32.036  -14.192 -0.618  1.00 104.71 ? 202 SER A C   1 
ATOM 1500  O O   . SER A 1 208 ? 32.848  -15.033 -0.221  1.00 95.48  ? 202 SER A O   1 
ATOM 1501  C CB  . SER A 1 208 ? 31.990  -11.899 0.287   1.00 85.19  ? 202 SER A CB  1 
ATOM 1502  O OG  . SER A 1 208 ? 32.373  -10.549 0.073   1.00 74.84  ? 202 SER A OG  1 
ATOM 1503  N N   . LEU A 1 209 ? 30.785  -14.458 -0.954  1.00 52.68  ? 203 LEU A N   1 
ATOM 1504  C CA  . LEU A 1 209 ? 30.386  -15.861 -0.816  1.00 56.83  ? 203 LEU A CA  1 
ATOM 1505  C C   . LEU A 1 209 ? 31.199  -16.720 -1.766  1.00 59.23  ? 203 LEU A C   1 
ATOM 1506  O O   . LEU A 1 209 ? 31.640  -17.798 -1.365  1.00 63.30  ? 203 LEU A O   1 
ATOM 1507  C CB  . LEU A 1 209 ? 28.923  -15.799 -1.233  1.00 59.09  ? 203 LEU A CB  1 
ATOM 1508  C CG  . LEU A 1 209 ? 28.146  -17.109 -1.360  1.00 60.26  ? 203 LEU A CG  1 
ATOM 1509  C CD1 . LEU A 1 209 ? 27.662  -17.556 0.004   1.00 65.20  ? 203 LEU A CD1 1 
ATOM 1510  C CD2 . LEU A 1 209 ? 26.959  -16.828 -2.263  1.00 57.31  ? 203 LEU A CD2 1 
ATOM 1511  N N   . GLN A 1 210 ? 31.373  -16.258 -2.998  1.00 63.24  ? 204 GLN A N   1 
ATOM 1512  C CA  . GLN A 1 210 ? 32.079  -17.186 -3.902  1.00 68.16  ? 204 GLN A CA  1 
ATOM 1513  C C   . GLN A 1 210 ? 33.529  -17.474 -3.502  1.00 70.82  ? 204 GLN A C   1 
ATOM 1514  O O   . GLN A 1 210 ? 33.925  -18.648 -3.588  1.00 72.60  ? 204 GLN A O   1 
ATOM 1515  C CB  . GLN A 1 210 ? 31.989  -16.515 -5.268  1.00 75.06  ? 204 GLN A CB  1 
ATOM 1516  C CG  . GLN A 1 210 ? 33.321  -16.108 -5.887  1.00 84.83  ? 204 GLN A CG  1 
ATOM 1517  C CD  . GLN A 1 210 ? 33.263  -14.780 -6.608  1.00 104.05 ? 204 GLN A CD  1 
ATOM 1518  O OE1 . GLN A 1 210 ? 32.236  -14.400 -7.178  1.00 114.15 ? 204 GLN A OE1 1 
ATOM 1519  N NE2 . GLN A 1 210 ? 34.373  -14.057 -6.591  1.00 104.21 ? 204 GLN A NE2 1 
ATOM 1520  N N   . LYS A 1 211 ? 34.311  -16.452 -3.141  1.00 69.95  ? 205 LYS A N   1 
ATOM 1521  C CA  . LYS A 1 211 ? 35.685  -16.691 -2.635  1.00 67.55  ? 205 LYS A CA  1 
ATOM 1522  C C   . LYS A 1 211 ? 35.785  -17.403 -1.287  1.00 68.33  ? 205 LYS A C   1 
ATOM 1523  O O   . LYS A 1 211 ? 36.640  -18.290 -1.157  1.00 73.52  ? 205 LYS A O   1 
ATOM 1524  C CB  . LYS A 1 211 ? 36.421  -15.351 -2.617  1.00 71.13  ? 205 LYS A CB  1 
ATOM 1525  C CG  . LYS A 1 211 ? 37.880  -15.414 -3.037  1.00 77.35  ? 205 LYS A CG  1 
ATOM 1526  C CD  . LYS A 1 211 ? 38.103  -15.303 -4.540  1.00 85.15  ? 205 LYS A CD  1 
ATOM 1527  C CE  . LYS A 1 211 ? 39.308  -14.485 -4.888  1.00 92.05  ? 205 LYS A CE  1 
ATOM 1528  N NZ  . LYS A 1 211 ? 39.932  -14.910 -6.144  1.00 89.96  ? 205 LYS A NZ  1 
ATOM 1529  N N   . PHE A 1 212 ? 34.949  -17.001 -0.326  1.00 72.90  ? 206 PHE A N   1 
ATOM 1530  C CA  . PHE A 1 212 ? 35.110  -17.540 1.057   1.00 70.10  ? 206 PHE A CA  1 
ATOM 1531  C C   . PHE A 1 212 ? 34.145  -18.645 1.413   1.00 59.05  ? 206 PHE A C   1 
ATOM 1532  O O   . PHE A 1 212 ? 34.245  -19.216 2.501   1.00 59.36  ? 206 PHE A O   1 
ATOM 1533  C CB  . PHE A 1 212 ? 35.106  -16.302 1.954   1.00 67.83  ? 206 PHE A CB  1 
ATOM 1534  C CG  . PHE A 1 212 ? 36.208  -15.316 1.597   1.00 71.25  ? 206 PHE A CG  1 
ATOM 1535  C CD1 . PHE A 1 212 ? 37.544  -15.687 1.669   1.00 70.96  ? 206 PHE A CD1 1 
ATOM 1536  C CD2 . PHE A 1 212 ? 35.906  -14.029 1.171   1.00 68.05  ? 206 PHE A CD2 1 
ATOM 1537  C CE1 . PHE A 1 212 ? 38.546  -14.793 1.335   1.00 69.19  ? 206 PHE A CE1 1 
ATOM 1538  C CE2 . PHE A 1 212 ? 36.913  -13.141 0.838   1.00 66.93  ? 206 PHE A CE2 1 
ATOM 1539  C CZ  . PHE A 1 212 ? 38.228  -13.525 0.920   1.00 66.95  ? 206 PHE A CZ  1 
ATOM 1540  N N   . GLY A 1 213 ? 33.263  -18.974 0.497   1.00 56.28  ? 207 GLY A N   1 
ATOM 1541  C CA  . GLY A 1 213 ? 32.271  -20.003 0.797   1.00 59.99  ? 207 GLY A CA  1 
ATOM 1542  C C   . GLY A 1 213 ? 31.008  -19.536 1.472   1.00 61.32  ? 207 GLY A C   1 
ATOM 1543  O O   . GLY A 1 213 ? 30.892  -18.336 1.748   1.00 58.75  ? 207 GLY A O   1 
ATOM 1544  N N   . GLU A 1 214 ? 30.099  -20.468 1.720   1.00 64.56  ? 208 GLU A N   1 
ATOM 1545  C CA  . GLU A 1 214 ? 28.806  -20.252 2.350   1.00 65.62  ? 208 GLU A CA  1 
ATOM 1546  C C   . GLU A 1 214 ? 28.968  -20.165 3.866   1.00 62.23  ? 208 GLU A C   1 
ATOM 1547  O O   . GLU A 1 214 ? 28.100  -19.651 4.563   1.00 55.23  ? 208 GLU A O   1 
ATOM 1548  C CB  . GLU A 1 214 ? 27.892  -21.429 2.006   1.00 69.03  ? 208 GLU A CB  1 
ATOM 1549  C CG  . GLU A 1 214 ? 26.425  -21.211 2.359   1.00 77.71  ? 208 GLU A CG  1 
ATOM 1550  C CD  . GLU A 1 214 ? 25.600  -22.489 2.356   1.00 91.55  ? 208 GLU A CD  1 
ATOM 1551  O OE1 . GLU A 1 214 ? 25.646  -23.249 3.357   1.00 92.75  ? 208 GLU A OE1 1 
ATOM 1552  O OE2 . GLU A 1 214 ? 24.917  -22.736 1.337   1.00 103.86 ? 208 GLU A OE2 1 
ATOM 1553  N N   . ARG A 1 215 ? 30.077  -20.705 4.376   1.00 63.93  ? 209 ARG A N   1 
ATOM 1554  C CA  . ARG A 1 215 ? 30.322  -20.715 5.802   1.00 58.91  ? 209 ARG A CA  1 
ATOM 1555  C C   . ARG A 1 215 ? 30.591  -19.294 6.267   1.00 58.73  ? 209 ARG A C   1 
ATOM 1556  O O   . ARG A 1 215 ? 29.871  -18.772 7.109   1.00 56.83  ? 209 ARG A O   1 
ATOM 1557  C CB  . ARG A 1 215 ? 31.519  -21.596 6.158   1.00 60.32  ? 209 ARG A CB  1 
ATOM 1558  C CG  . ARG A 1 215 ? 31.705  -21.657 7.666   1.00 56.70  ? 209 ARG A CG  1 
ATOM 1559  C CD  . ARG A 1 215 ? 32.000  -23.074 8.104   1.00 55.69  ? 209 ARG A CD  1 
ATOM 1560  N NE  . ARG A 1 215 ? 32.315  -23.125 9.529   1.00 55.89  ? 209 ARG A NE  1 
ATOM 1561  C CZ  . ARG A 1 215 ? 33.412  -22.635 10.087  1.00 59.21  ? 209 ARG A CZ  1 
ATOM 1562  N NH1 . ARG A 1 215 ? 34.356  -22.092 9.343   1.00 56.12  ? 209 ARG A NH1 1 
ATOM 1563  N NH2 . ARG A 1 215 ? 33.576  -22.710 11.397  1.00 66.71  ? 209 ARG A NH2 1 
ATOM 1564  N N   . ALA A 1 216 ? 31.619  -18.665 5.693   1.00 61.45  ? 210 ALA A N   1 
ATOM 1565  C CA  . ALA A 1 216 ? 31.970  -17.307 6.081   1.00 59.91  ? 210 ALA A CA  1 
ATOM 1566  C C   . ALA A 1 216 ? 30.747  -16.377 6.013   1.00 58.18  ? 210 ALA A C   1 
ATOM 1567  O O   . ALA A 1 216 ? 30.597  -15.507 6.869   1.00 56.86  ? 210 ALA A O   1 
ATOM 1568  C CB  . ALA A 1 216 ? 33.123  -16.817 5.230   1.00 56.35  ? 210 ALA A CB  1 
ATOM 1569  N N   . PHE A 1 217 ? 29.859  -16.571 5.020   1.00 54.99  ? 211 PHE A N   1 
ATOM 1570  C CA  . PHE A 1 217 ? 28.683  -15.728 4.837   1.00 50.66  ? 211 PHE A CA  1 
ATOM 1571  C C   . PHE A 1 217 ? 27.676  -15.976 5.954   1.00 54.28  ? 211 PHE A C   1 
ATOM 1572  O O   . PHE A 1 217 ? 27.154  -15.027 6.534   1.00 56.02  ? 211 PHE A O   1 
ATOM 1573  C CB  . PHE A 1 217 ? 28.011  -15.995 3.492   1.00 52.78  ? 211 PHE A CB  1 
ATOM 1574  C CG  . PHE A 1 217 ? 26.778  -15.156 3.193   1.00 57.91  ? 211 PHE A CG  1 
ATOM 1575  C CD1 . PHE A 1 217 ? 25.516  -15.552 3.629   1.00 60.31  ? 211 PHE A CD1 1 
ATOM 1576  C CD2 . PHE A 1 217 ? 26.871  -13.995 2.431   1.00 60.35  ? 211 PHE A CD2 1 
ATOM 1577  C CE1 . PHE A 1 217 ? 24.390  -14.789 3.330   1.00 60.04  ? 211 PHE A CE1 1 
ATOM 1578  C CE2 . PHE A 1 217 ? 25.737  -13.243 2.127   1.00 61.89  ? 211 PHE A CE2 1 
ATOM 1579  C CZ  . PHE A 1 217 ? 24.501  -13.637 2.579   1.00 57.62  ? 211 PHE A CZ  1 
ATOM 1580  N N   . LYS A 1 218 ? 27.392  -17.255 6.238   1.00 56.93  ? 212 LYS A N   1 
ATOM 1581  C CA  . LYS A 1 218 ? 26.546  -17.622 7.367   1.00 55.21  ? 212 LYS A CA  1 
ATOM 1582  C C   . LYS A 1 218 ? 27.039  -16.927 8.642   1.00 50.30  ? 212 LYS A C   1 
ATOM 1583  O O   . LYS A 1 218 ? 26.222  -16.432 9.416   1.00 50.23  ? 212 LYS A O   1 
ATOM 1584  C CB  . LYS A 1 218 ? 26.490  -19.133 7.627   1.00 57.05  ? 212 LYS A CB  1 
ATOM 1585  C CG  . LYS A 1 218 ? 25.418  -20.002 6.955   1.00 62.36  ? 212 LYS A CG  1 
ATOM 1586  C CD  . LYS A 1 218 ? 25.702  -21.474 7.283   1.00 70.50  ? 212 LYS A CD  1 
ATOM 1587  C CE  . LYS A 1 218 ? 24.769  -22.529 6.762   1.00 76.06  ? 212 LYS A CE  1 
ATOM 1588  N NZ  . LYS A 1 218 ? 23.449  -22.466 7.395   1.00 79.86  ? 212 LYS A NZ  1 
ATOM 1589  N N   . ALA A 1 219 ? 28.364  -16.901 8.869   1.00 42.49  ? 213 ALA A N   1 
ATOM 1590  C CA  . ALA A 1 219 ? 28.916  -16.252 10.052  1.00 40.57  ? 213 ALA A CA  1 
ATOM 1591  C C   . ALA A 1 219 ? 28.635  -14.756 9.982   1.00 40.87  ? 213 ALA A C   1 
ATOM 1592  O O   . ALA A 1 219 ? 28.143  -14.176 10.939  1.00 39.82  ? 213 ALA A O   1 
ATOM 1593  C CB  . ALA A 1 219 ? 30.402  -16.527 10.210  1.00 39.87  ? 213 ALA A CB  1 
ATOM 1594  N N   . TRP A 1 220 ? 28.939  -14.132 8.842   1.00 43.97  ? 214 TRP A N   1 
ATOM 1595  C CA  . TRP A 1 220 ? 28.661  -12.718 8.683   1.00 49.45  ? 214 TRP A CA  1 
ATOM 1596  C C   . TRP A 1 220 ? 27.230  -12.433 9.120   1.00 54.26  ? 214 TRP A C   1 
ATOM 1597  O O   . TRP A 1 220 ? 27.039  -11.594 10.000  1.00 60.89  ? 214 TRP A O   1 
ATOM 1598  C CB  . TRP A 1 220 ? 28.894  -12.249 7.241   1.00 54.34  ? 214 TRP A CB  1 
ATOM 1599  C CG  . TRP A 1 220 ? 28.410  -10.842 7.002   1.00 53.70  ? 214 TRP A CG  1 
ATOM 1600  C CD1 . TRP A 1 220 ? 29.087  -9.683  7.252   1.00 49.64  ? 214 TRP A CD1 1 
ATOM 1601  C CD2 . TRP A 1 220 ? 27.116  -10.456 6.489   1.00 50.50  ? 214 TRP A CD2 1 
ATOM 1602  N NE1 . TRP A 1 220 ? 28.306  -8.604  6.939   1.00 49.56  ? 214 TRP A NE1 1 
ATOM 1603  C CE2 . TRP A 1 220 ? 27.095  -9.047  6.470   1.00 49.70  ? 214 TRP A CE2 1 
ATOM 1604  C CE3 . TRP A 1 220 ? 25.992  -11.159 6.045   1.00 49.53  ? 214 TRP A CE3 1 
ATOM 1605  C CZ2 . TRP A 1 220 ? 25.985  -8.336  6.029   1.00 50.09  ? 214 TRP A CZ2 1 
ATOM 1606  C CZ3 . TRP A 1 220 ? 24.902  -10.452 5.592   1.00 50.22  ? 214 TRP A CZ3 1 
ATOM 1607  C CH2 . TRP A 1 220 ? 24.896  -9.061  5.601   1.00 51.49  ? 214 TRP A CH2 1 
ATOM 1608  N N   . ALA A 1 221 ? 26.270  -13.169 8.522   1.00 53.63  ? 215 ALA A N   1 
ATOM 1609  C CA  . ALA A 1 221 ? 24.835  -12.984 8.731   1.00 51.93  ? 215 ALA A CA  1 
ATOM 1610  C C   . ALA A 1 221 ? 24.439  -13.126 10.201  1.00 53.84  ? 215 ALA A C   1 
ATOM 1611  O O   . ALA A 1 221 ? 23.569  -12.404 10.666  1.00 55.61  ? 215 ALA A O   1 
ATOM 1612  C CB  . ALA A 1 221 ? 24.060  -13.978 7.901   1.00 50.78  ? 215 ALA A CB  1 
ATOM 1613  N N   . VAL A 1 222 ? 25.036  -14.089 10.912  1.00 59.21  ? 216 VAL A N   1 
ATOM 1614  C CA  . VAL A 1 222 ? 24.802  -14.252 12.340  1.00 66.43  ? 216 VAL A CA  1 
ATOM 1615  C C   . VAL A 1 222 ? 25.065  -12.907 13.011  1.00 63.13  ? 216 VAL A C   1 
ATOM 1616  O O   . VAL A 1 222 ? 24.164  -12.321 13.616  1.00 59.11  ? 216 VAL A O   1 
ATOM 1617  C CB  . VAL A 1 222 ? 25.662  -15.383 12.960  1.00 70.72  ? 216 VAL A CB  1 
ATOM 1618  C CG1 . VAL A 1 222 ? 25.869  -15.237 14.468  1.00 72.15  ? 216 VAL A CG1 1 
ATOM 1619  C CG2 . VAL A 1 222 ? 25.105  -16.765 12.642  1.00 67.78  ? 216 VAL A CG2 1 
ATOM 1620  N N   . ALA A 1 223 ? 26.311  -12.437 12.871  1.00 60.57  ? 217 ALA A N   1 
ATOM 1621  C CA  . ALA A 1 223 ? 26.754  -11.219 13.518  1.00 58.87  ? 217 ALA A CA  1 
ATOM 1622  C C   . ALA A 1 223 ? 25.737  -10.116 13.252  1.00 58.33  ? 217 ALA A C   1 
ATOM 1623  O O   . ALA A 1 223 ? 25.259  -9.511  14.202  1.00 55.52  ? 217 ALA A O   1 
ATOM 1624  C CB  . ALA A 1 223 ? 28.132  -10.865 13.028  1.00 60.35  ? 217 ALA A CB  1 
ATOM 1625  N N   . ARG A 1 224 ? 25.372  -9.940  11.970  1.00 63.73  ? 218 ARG A N   1 
ATOM 1626  C CA  . ARG A 1 224 ? 24.476  -8.888  11.501  1.00 76.27  ? 218 ARG A CA  1 
ATOM 1627  C C   . ARG A 1 224 ? 23.122  -8.938  12.213  1.00 73.62  ? 218 ARG A C   1 
ATOM 1628  O O   . ARG A 1 224 ? 22.641  -7.909  12.686  1.00 83.36  ? 218 ARG A O   1 
ATOM 1629  C CB  . ARG A 1 224 ? 24.216  -8.993  9.988   1.00 91.12  ? 218 ARG A CB  1 
ATOM 1630  C CG  . ARG A 1 224 ? 23.512  -7.812  9.323   1.00 102.79 ? 218 ARG A CG  1 
ATOM 1631  C CD  . ARG A 1 224 ? 24.458  -6.633  9.101   1.00 114.34 ? 218 ARG A CD  1 
ATOM 1632  N NE  . ARG A 1 224 ? 23.801  -5.323  9.018   1.00 112.70 ? 218 ARG A NE  1 
ATOM 1633  C CZ  . ARG A 1 224 ? 23.761  -4.438  10.017  1.00 109.72 ? 218 ARG A CZ  1 
ATOM 1634  N NH1 . ARG A 1 224 ? 24.152  -4.766  11.239  1.00 99.19  ? 218 ARG A NH1 1 
ATOM 1635  N NH2 . ARG A 1 224 ? 23.288  -3.228  9.794   1.00 116.57 ? 218 ARG A NH2 1 
ATOM 1636  N N   . LEU A 1 225 ? 22.500  -10.122 12.260  1.00 65.35  ? 219 LEU A N   1 
ATOM 1637  C CA  . LEU A 1 225 ? 21.108  -10.242 12.669  1.00 62.30  ? 219 LEU A CA  1 
ATOM 1638  C C   . LEU A 1 225 ? 20.987  -10.255 14.196  1.00 67.53  ? 219 LEU A C   1 
ATOM 1639  O O   . LEU A 1 225 ? 19.936  -9.892  14.734  1.00 69.40  ? 219 LEU A O   1 
ATOM 1640  C CB  . LEU A 1 225 ? 20.472  -11.482 12.035  1.00 57.23  ? 219 LEU A CB  1 
ATOM 1641  C CG  . LEU A 1 225 ? 20.341  -11.482 10.507  1.00 52.80  ? 219 LEU A CG  1 
ATOM 1642  C CD1 . LEU A 1 225 ? 19.638  -12.720 9.989   1.00 50.18  ? 219 LEU A CD1 1 
ATOM 1643  C CD2 . LEU A 1 225 ? 19.610  -10.256 10.039  1.00 55.17  ? 219 LEU A CD2 1 
ATOM 1644  N N   . SER A 1 226 ? 22.058  -10.670 14.892  1.00 66.97  ? 220 SER A N   1 
ATOM 1645  C CA  . SER A 1 226 ? 22.033  -10.803 16.347  1.00 64.75  ? 220 SER A CA  1 
ATOM 1646  C C   . SER A 1 226 ? 22.264  -9.444  17.007  1.00 57.44  ? 220 SER A C   1 
ATOM 1647  O O   . SER A 1 226 ? 21.919  -9.240  18.179  1.00 46.56  ? 220 SER A O   1 
ATOM 1648  C CB  . SER A 1 226 ? 23.058  -11.802 16.834  1.00 67.67  ? 220 SER A CB  1 
ATOM 1649  O OG  . SER A 1 226 ? 23.117  -12.955 16.009  1.00 72.13  ? 220 SER A OG  1 
ATOM 1650  N N   . GLN A 1 227 ? 22.914  -8.551  16.243  1.00 52.76  ? 221 GLN A N   1 
ATOM 1651  C CA  . GLN A 1 227 ? 22.981  -7.134  16.563  1.00 48.13  ? 221 GLN A CA  1 
ATOM 1652  C C   . GLN A 1 227 ? 21.619  -6.487  16.367  1.00 44.99  ? 221 GLN A C   1 
ATOM 1653  O O   . GLN A 1 227 ? 21.185  -5.729  17.229  1.00 46.31  ? 221 GLN A O   1 
ATOM 1654  C CB  . GLN A 1 227 ? 23.961  -6.383  15.673  1.00 43.70  ? 221 GLN A CB  1 
ATOM 1655  C CG  . GLN A 1 227 ? 25.402  -6.497  16.139  1.00 46.02  ? 221 GLN A CG  1 
ATOM 1656  C CD  . GLN A 1 227 ? 26.332  -5.711  15.251  1.00 52.05  ? 221 GLN A CD  1 
ATOM 1657  O OE1 . GLN A 1 227 ? 25.989  -5.398  14.105  1.00 62.26  ? 221 GLN A OE1 1 
ATOM 1658  N NE2 . GLN A 1 227 ? 27.513  -5.389  15.762  1.00 53.80  ? 221 GLN A NE2 1 
ATOM 1659  N N   . ARG A 1 228 ? 20.975  -6.798  15.237  1.00 43.61  ? 222 ARG A N   1 
ATOM 1660  C CA  . ARG A 1 228 ? 19.674  -6.243  14.912  1.00 53.03  ? 222 ARG A CA  1 
ATOM 1661  C C   . ARG A 1 228 ? 18.603  -6.784  15.856  1.00 52.65  ? 222 ARG A C   1 
ATOM 1662  O O   . ARG A 1 228 ? 17.610  -6.094  16.095  1.00 56.15  ? 222 ARG A O   1 
ATOM 1663  C CB  . ARG A 1 228 ? 19.210  -6.499  13.470  1.00 60.91  ? 222 ARG A CB  1 
ATOM 1664  C CG  . ARG A 1 228 ? 19.729  -5.498  12.449  1.00 69.76  ? 222 ARG A CG  1 
ATOM 1665  C CD  . ARG A 1 228 ? 19.088  -5.666  11.073  1.00 76.94  ? 222 ARG A CD  1 
ATOM 1666  N NE  . ARG A 1 228 ? 19.811  -4.945  10.016  1.00 87.85  ? 222 ARG A NE  1 
ATOM 1667  C CZ  . ARG A 1 228 ? 19.996  -3.617  9.951   1.00 108.55 ? 222 ARG A CZ  1 
ATOM 1668  N NH1 . ARG A 1 228 ? 19.529  -2.815  10.897  1.00 119.50 ? 222 ARG A NH1 1 
ATOM 1669  N NH2 . ARG A 1 228 ? 20.644  -3.081  8.928   1.00 105.46 ? 222 ARG A NH2 1 
ATOM 1670  N N   . PHE A 1 229 ? 18.771  -8.018  16.346  1.00 50.35  ? 223 PHE A N   1 
ATOM 1671  C CA  . PHE A 1 229 ? 17.717  -8.658  17.117  1.00 51.81  ? 223 PHE A CA  1 
ATOM 1672  C C   . PHE A 1 229 ? 18.314  -9.375  18.320  1.00 50.67  ? 223 PHE A C   1 
ATOM 1673  O O   . PHE A 1 229 ? 18.304  -10.594 18.365  1.00 53.94  ? 223 PHE A O   1 
ATOM 1674  C CB  . PHE A 1 229 ? 16.988  -9.670  16.232  1.00 54.62  ? 223 PHE A CB  1 
ATOM 1675  C CG  . PHE A 1 229 ? 16.542  -9.153  14.874  1.00 61.95  ? 223 PHE A CG  1 
ATOM 1676  C CD1 . PHE A 1 229 ? 15.839  -7.955  14.756  1.00 66.08  ? 223 PHE A CD1 1 
ATOM 1677  C CD2 . PHE A 1 229 ? 16.833  -9.870  13.714  1.00 67.19  ? 223 PHE A CD2 1 
ATOM 1678  C CE1 . PHE A 1 229 ? 15.419  -7.498  13.511  1.00 70.79  ? 223 PHE A CE1 1 
ATOM 1679  C CE2 . PHE A 1 229 ? 16.422  -9.405  12.469  1.00 69.68  ? 223 PHE A CE2 1 
ATOM 1680  C CZ  . PHE A 1 229 ? 15.713  -8.221  12.371  1.00 71.60  ? 223 PHE A CZ  1 
ATOM 1681  N N   . PRO A 1 230 ? 18.862  -8.667  19.328  1.00 49.80  ? 224 PRO A N   1 
ATOM 1682  C CA  . PRO A 1 230 ? 19.457  -9.329  20.493  1.00 51.69  ? 224 PRO A CA  1 
ATOM 1683  C C   . PRO A 1 230 ? 18.482  -10.099 21.383  1.00 50.58  ? 224 PRO A C   1 
ATOM 1684  O O   . PRO A 1 230 ? 18.901  -10.913 22.207  1.00 44.28  ? 224 PRO A O   1 
ATOM 1685  C CB  . PRO A 1 230 ? 20.105  -8.148  21.235  1.00 54.14  ? 224 PRO A CB  1 
ATOM 1686  C CG  . PRO A 1 230 ? 19.251  -6.970  20.861  1.00 52.75  ? 224 PRO A CG  1 
ATOM 1687  C CD  . PRO A 1 230 ? 18.969  -7.205  19.389  1.00 52.13  ? 224 PRO A CD  1 
ATOM 1688  N N   . LYS A 1 231 ? 17.183  -9.832  21.206  1.00 59.77  ? 225 LYS A N   1 
ATOM 1689  C CA  . LYS A 1 231 ? 16.136  -10.448 22.006  1.00 64.50  ? 225 LYS A CA  1 
ATOM 1690  C C   . LYS A 1 231 ? 15.888  -11.878 21.538  1.00 72.05  ? 225 LYS A C   1 
ATOM 1691  O O   . LYS A 1 231 ? 15.812  -12.780 22.370  1.00 75.52  ? 225 LYS A O   1 
ATOM 1692  C CB  . LYS A 1 231 ? 14.844  -9.631  21.907  1.00 68.51  ? 225 LYS A CB  1 
ATOM 1693  C CG  . LYS A 1 231 ? 14.919  -8.261  22.572  1.00 73.68  ? 225 LYS A CG  1 
ATOM 1694  C CD  . LYS A 1 231 ? 15.092  -8.326  24.085  1.00 73.60  ? 225 LYS A CD  1 
ATOM 1695  C CE  . LYS A 1 231 ? 15.174  -6.994  24.762  1.00 77.77  ? 225 LYS A CE  1 
ATOM 1696  N NZ  . LYS A 1 231 ? 14.174  -6.054  24.252  1.00 85.11  ? 225 LYS A NZ  1 
ATOM 1697  N N   . ALA A 1 232 ? 15.774  -12.061 20.210  1.00 73.86  ? 226 ALA A N   1 
ATOM 1698  C CA  . ALA A 1 232 ? 15.496  -13.353 19.591  1.00 67.46  ? 226 ALA A CA  1 
ATOM 1699  C C   . ALA A 1 232 ? 16.476  -14.426 20.072  1.00 68.60  ? 226 ALA A C   1 
ATOM 1700  O O   . ALA A 1 232 ? 17.615  -14.140 20.456  1.00 53.38  ? 226 ALA A O   1 
ATOM 1701  C CB  . ALA A 1 232 ? 15.515  -13.237 18.074  1.00 59.46  ? 226 ALA A CB  1 
ATOM 1702  N N   . GLU A 1 233 ? 15.990  -15.674 20.043  1.00 77.05  ? 227 GLU A N   1 
ATOM 1703  C CA  . GLU A 1 233 ? 16.742  -16.843 20.485  1.00 83.76  ? 227 GLU A CA  1 
ATOM 1704  C C   . GLU A 1 233 ? 17.767  -17.222 19.410  1.00 68.94  ? 227 GLU A C   1 
ATOM 1705  O O   . GLU A 1 233 ? 17.577  -16.934 18.227  1.00 56.69  ? 227 GLU A O   1 
ATOM 1706  C CB  . GLU A 1 233 ? 15.726  -17.937 20.850  1.00 90.56  ? 227 GLU A CB  1 
ATOM 1707  C CG  . GLU A 1 233 ? 14.892  -18.439 19.667  1.00 92.80  ? 227 GLU A CG  1 
ATOM 1708  C CD  . GLU A 1 233 ? 13.379  -18.565 19.827  1.00 90.64  ? 227 GLU A CD  1 
ATOM 1709  O OE1 . GLU A 1 233 ? 12.803  -17.521 20.193  1.00 90.66  ? 227 GLU A OE1 1 
ATOM 1710  O OE2 . GLU A 1 233 ? 12.763  -19.630 19.542  1.00 76.11  ? 227 GLU A OE2 1 
ATOM 1711  N N   . PHE A 1 234 ? 18.856  -17.882 19.817  1.00 61.40  ? 228 PHE A N   1 
ATOM 1712  C CA  . PHE A 1 234 ? 19.889  -18.267 18.868  1.00 57.41  ? 228 PHE A CA  1 
ATOM 1713  C C   . PHE A 1 234 ? 19.326  -19.237 17.826  1.00 53.95  ? 228 PHE A C   1 
ATOM 1714  O O   . PHE A 1 234 ? 19.883  -19.360 16.739  1.00 49.16  ? 228 PHE A O   1 
ATOM 1715  C CB  . PHE A 1 234 ? 21.107  -18.904 19.544  1.00 58.51  ? 228 PHE A CB  1 
ATOM 1716  C CG  . PHE A 1 234 ? 22.069  -19.548 18.557  1.00 57.34  ? 228 PHE A CG  1 
ATOM 1717  C CD1 . PHE A 1 234 ? 23.046  -18.791 17.925  1.00 55.31  ? 228 PHE A CD1 1 
ATOM 1718  C CD2 . PHE A 1 234 ? 21.969  -20.895 18.230  1.00 64.61  ? 228 PHE A CD2 1 
ATOM 1719  C CE1 . PHE A 1 234 ? 23.912  -19.357 17.003  1.00 54.53  ? 228 PHE A CE1 1 
ATOM 1720  C CE2 . PHE A 1 234 ? 22.842  -21.463 17.314  1.00 67.41  ? 228 PHE A CE2 1 
ATOM 1721  C CZ  . PHE A 1 234 ? 23.813  -20.690 16.703  1.00 63.92  ? 228 PHE A CZ  1 
ATOM 1722  N N   . ALA A 1 235 ? 18.246  -19.948 18.168  1.00 54.82  ? 229 ALA A N   1 
ATOM 1723  C CA  . ALA A 1 235 ? 17.601  -20.852 17.228  1.00 54.40  ? 229 ALA A CA  1 
ATOM 1724  C C   . ALA A 1 235 ? 16.751  -20.108 16.207  1.00 53.01  ? 229 ALA A C   1 
ATOM 1725  O O   . ALA A 1 235 ? 16.564  -20.596 15.096  1.00 56.11  ? 229 ALA A O   1 
ATOM 1726  C CB  . ALA A 1 235 ? 16.742  -21.840 17.952  1.00 58.82  ? 229 ALA A CB  1 
ATOM 1727  N N   . GLU A 1 236 ? 16.214  -18.948 16.582  1.00 53.18  ? 230 GLU A N   1 
ATOM 1728  C CA  . GLU A 1 236 ? 15.426  -18.163 15.648  1.00 55.25  ? 230 GLU A CA  1 
ATOM 1729  C C   . GLU A 1 236 ? 16.351  -17.437 14.673  1.00 50.48  ? 230 GLU A C   1 
ATOM 1730  O O   . GLU A 1 236 ? 16.083  -17.423 13.485  1.00 45.61  ? 230 GLU A O   1 
ATOM 1731  C CB  . GLU A 1 236 ? 14.516  -17.196 16.394  1.00 64.95  ? 230 GLU A CB  1 
ATOM 1732  C CG  . GLU A 1 236 ? 13.415  -16.603 15.524  1.00 69.61  ? 230 GLU A CG  1 
ATOM 1733  C CD  . GLU A 1 236 ? 12.394  -17.630 15.082  1.00 68.93  ? 230 GLU A CD  1 
ATOM 1734  O OE1 . GLU A 1 236 ? 11.754  -18.269 15.942  1.00 66.85  ? 230 GLU A OE1 1 
ATOM 1735  O OE2 . GLU A 1 236 ? 12.254  -17.777 13.855  1.00 77.99  ? 230 GLU A OE2 1 
ATOM 1736  N N   . VAL A 1 237 ? 17.462  -16.881 15.166  1.00 50.48  ? 231 VAL A N   1 
ATOM 1737  C CA  . VAL A 1 237 ? 18.468  -16.279 14.303  1.00 51.38  ? 231 VAL A CA  1 
ATOM 1738  C C   . VAL A 1 237 ? 18.947  -17.295 13.269  1.00 51.10  ? 231 VAL A C   1 
ATOM 1739  O O   . VAL A 1 237 ? 18.830  -17.059 12.066  1.00 50.87  ? 231 VAL A O   1 
ATOM 1740  C CB  . VAL A 1 237 ? 19.643  -15.735 15.137  1.00 53.54  ? 231 VAL A CB  1 
ATOM 1741  C CG1 . VAL A 1 237 ? 20.927  -15.571 14.326  1.00 50.60  ? 231 VAL A CG1 1 
ATOM 1742  C CG2 . VAL A 1 237 ? 19.257  -14.422 15.812  1.00 59.29  ? 231 VAL A CG2 1 
ATOM 1743  N N   . SER A 1 238 ? 19.493  -18.410 13.767  1.00 52.76  ? 232 SER A N   1 
ATOM 1744  C CA  . SER A 1 238 ? 20.075  -19.476 12.961  1.00 54.09  ? 232 SER A CA  1 
ATOM 1745  C C   . SER A 1 238 ? 19.186  -19.879 11.775  1.00 54.52  ? 232 SER A C   1 
ATOM 1746  O O   . SER A 1 238 ? 19.694  -20.063 10.663  1.00 45.78  ? 232 SER A O   1 
ATOM 1747  C CB  . SER A 1 238 ? 20.367  -20.661 13.843  1.00 52.64  ? 232 SER A CB  1 
ATOM 1748  O OG  . SER A 1 238 ? 20.939  -21.710 13.083  1.00 55.14  ? 232 SER A OG  1 
ATOM 1749  N N   . LYS A 1 239 ? 17.874  -20.036 12.041  1.00 55.84  ? 233 LYS A N   1 
ATOM 1750  C CA  . LYS A 1 239 ? 16.857  -20.349 11.041  1.00 56.00  ? 233 LYS A CA  1 
ATOM 1751  C C   . LYS A 1 239 ? 16.844  -19.301 9.929   1.00 52.52  ? 233 LYS A C   1 
ATOM 1752  O O   . LYS A 1 239 ? 16.797  -19.655 8.753   1.00 42.97  ? 233 LYS A O   1 
ATOM 1753  C CB  . LYS A 1 239 ? 15.479  -20.361 11.712  1.00 59.38  ? 233 LYS A CB  1 
ATOM 1754  C CG  . LYS A 1 239 ? 14.321  -20.926 10.909  1.00 63.68  ? 233 LYS A CG  1 
ATOM 1755  C CD  . LYS A 1 239 ? 13.563  -20.001 9.967   1.00 69.19  ? 233 LYS A CD  1 
ATOM 1756  C CE  . LYS A 1 239 ? 12.593  -20.848 9.183   1.00 80.28  ? 233 LYS A CE  1 
ATOM 1757  N NZ  . LYS A 1 239 ? 11.903  -20.160 8.089   1.00 88.89  ? 233 LYS A NZ  1 
ATOM 1758  N N   . LEU A 1 240 ? 16.862  -18.024 10.349  1.00 54.31  ? 234 LEU A N   1 
ATOM 1759  C CA  . LEU A 1 240 ? 16.842  -16.862 9.471   1.00 52.05  ? 234 LEU A CA  1 
ATOM 1760  C C   . LEU A 1 240 ? 18.107  -16.865 8.621   1.00 50.65  ? 234 LEU A C   1 
ATOM 1761  O O   . LEU A 1 240 ? 18.025  -16.690 7.408   1.00 49.17  ? 234 LEU A O   1 
ATOM 1762  C CB  . LEU A 1 240 ? 16.724  -15.554 10.264  1.00 52.60  ? 234 LEU A CB  1 
ATOM 1763  C CG  . LEU A 1 240 ? 15.450  -15.374 11.106  1.00 55.63  ? 234 LEU A CG  1 
ATOM 1764  C CD1 . LEU A 1 240 ? 15.654  -14.276 12.142  1.00 55.25  ? 234 LEU A CD1 1 
ATOM 1765  C CD2 . LEU A 1 240 ? 14.161  -15.125 10.306  1.00 52.76  ? 234 LEU A CD2 1 
ATOM 1766  N N   . VAL A 1 241 ? 19.263  -17.087 9.263   1.00 48.69  ? 235 VAL A N   1 
ATOM 1767  C CA  . VAL A 1 241 ? 20.543  -17.036 8.566   1.00 49.90  ? 235 VAL A CA  1 
ATOM 1768  C C   . VAL A 1 241 ? 20.555  -18.072 7.435   1.00 56.06  ? 235 VAL A C   1 
ATOM 1769  O O   . VAL A 1 241 ? 21.184  -17.842 6.399   1.00 58.32  ? 235 VAL A O   1 
ATOM 1770  C CB  . VAL A 1 241 ? 21.764  -17.186 9.505   1.00 43.96  ? 235 VAL A CB  1 
ATOM 1771  C CG1 . VAL A 1 241 ? 23.069  -17.455 8.761   1.00 40.80  ? 235 VAL A CG1 1 
ATOM 1772  C CG2 . VAL A 1 241 ? 21.943  -15.961 10.392  1.00 43.41  ? 235 VAL A CG2 1 
ATOM 1773  N N   . THR A 1 242 ? 19.868  -19.210 7.625   1.00 57.55  ? 236 THR A N   1 
ATOM 1774  C CA  . THR A 1 242 ? 19.856  -20.251 6.609   1.00 54.22  ? 236 THR A CA  1 
ATOM 1775  C C   . THR A 1 242 ? 19.044  -19.781 5.404   1.00 56.77  ? 236 THR A C   1 
ATOM 1776  O O   . THR A 1 242 ? 19.440  -20.015 4.266   1.00 56.86  ? 236 THR A O   1 
ATOM 1777  C CB  . THR A 1 242 ? 19.307  -21.557 7.172   1.00 50.44  ? 236 THR A CB  1 
ATOM 1778  O OG1 . THR A 1 242 ? 20.336  -22.125 7.975   1.00 44.09  ? 236 THR A OG1 1 
ATOM 1779  C CG2 . THR A 1 242 ? 18.985  -22.543 6.066   1.00 53.97  ? 236 THR A CG2 1 
ATOM 1780  N N   . ASP A 1 243 ? 17.912  -19.122 5.682   1.00 63.26  ? 237 ASP A N   1 
ATOM 1781  C CA  . ASP A 1 243 ? 17.023  -18.586 4.661   1.00 66.10  ? 237 ASP A CA  1 
ATOM 1782  C C   . ASP A 1 243 ? 17.651  -17.381 3.960   1.00 63.92  ? 237 ASP A C   1 
ATOM 1783  O O   . ASP A 1 243 ? 17.559  -17.248 2.740   1.00 62.82  ? 237 ASP A O   1 
ATOM 1784  C CB  . ASP A 1 243 ? 15.659  -18.259 5.248   1.00 64.39  ? 237 ASP A CB  1 
ATOM 1785  C CG  . ASP A 1 243 ? 14.816  -19.484 5.574   1.00 73.72  ? 237 ASP A CG  1 
ATOM 1786  O OD1 . ASP A 1 243 ? 15.363  -20.617 5.512   1.00 67.05  ? 237 ASP A OD1 1 
ATOM 1787  O OD2 . ASP A 1 243 ? 13.610  -19.303 5.850   1.00 90.62  ? 237 ASP A OD2 1 
ATOM 1788  N N   . LEU A 1 244 ? 18.296  -16.510 4.737   1.00 60.03  ? 238 LEU A N   1 
ATOM 1789  C CA  . LEU A 1 244 ? 18.943  -15.342 4.175   1.00 56.74  ? 238 LEU A CA  1 
ATOM 1790  C C   . LEU A 1 244 ? 20.101  -15.753 3.282   1.00 53.59  ? 238 LEU A C   1 
ATOM 1791  O O   . LEU A 1 244 ? 20.386  -15.073 2.303   1.00 55.37  ? 238 LEU A O   1 
ATOM 1792  C CB  . LEU A 1 244 ? 19.463  -14.422 5.267   1.00 60.15  ? 238 LEU A CB  1 
ATOM 1793  C CG  . LEU A 1 244 ? 20.044  -13.106 4.751   1.00 63.38  ? 238 LEU A CG  1 
ATOM 1794  C CD1 . LEU A 1 244 ? 18.914  -12.296 4.110   1.00 59.23  ? 238 LEU A CD1 1 
ATOM 1795  C CD2 . LEU A 1 244 ? 20.772  -12.351 5.871   1.00 64.48  ? 238 LEU A CD2 1 
ATOM 1796  N N   . THR A 1 245 ? 20.790  -16.831 3.655   1.00 53.12  ? 239 THR A N   1 
ATOM 1797  C CA  . THR A 1 245 ? 21.946  -17.257 2.892   1.00 59.20  ? 239 THR A CA  1 
ATOM 1798  C C   . THR A 1 245 ? 21.461  -17.935 1.613   1.00 54.19  ? 239 THR A C   1 
ATOM 1799  O O   . THR A 1 245 ? 22.141  -17.878 0.590   1.00 51.84  ? 239 THR A O   1 
ATOM 1800  C CB  . THR A 1 245 ? 22.878  -18.137 3.734   1.00 67.75  ? 239 THR A CB  1 
ATOM 1801  O OG1 . THR A 1 245 ? 23.320  -17.394 4.870   1.00 66.56  ? 239 THR A OG1 1 
ATOM 1802  C CG2 . THR A 1 245 ? 24.125  -18.554 2.971   1.00 69.68  ? 239 THR A CG2 1 
ATOM 1803  N N   . LYS A 1 246 ? 20.274  -18.546 1.664   1.00 53.72  ? 240 LYS A N   1 
ATOM 1804  C CA  . LYS A 1 246 ? 19.731  -19.218 0.491   1.00 61.33  ? 240 LYS A CA  1 
ATOM 1805  C C   . LYS A 1 246 ? 19.461  -18.172 -0.589  1.00 64.70  ? 240 LYS A C   1 
ATOM 1806  O O   . LYS A 1 246 ? 19.966  -18.295 -1.711  1.00 63.94  ? 240 LYS A O   1 
ATOM 1807  C CB  . LYS A 1 246 ? 18.473  -20.026 0.844   1.00 66.34  ? 240 LYS A CB  1 
ATOM 1808  C CG  . LYS A 1 246 ? 17.838  -20.891 -0.254  1.00 70.23  ? 240 LYS A CG  1 
ATOM 1809  C CD  . LYS A 1 246 ? 18.771  -21.889 -0.935  1.00 77.26  ? 240 LYS A CD  1 
ATOM 1810  C CE  . LYS A 1 246 ? 18.137  -22.638 -2.086  1.00 83.25  ? 240 LYS A CE  1 
ATOM 1811  N NZ  . LYS A 1 246 ? 19.105  -23.185 -3.055  1.00 85.47  ? 240 LYS A NZ  1 
ATOM 1812  N N   . VAL A 1 247 ? 18.686  -17.143 -0.205  1.00 68.76  ? 241 VAL A N   1 
ATOM 1813  C CA  . VAL A 1 247 ? 18.273  -16.044 -1.075  1.00 69.19  ? 241 VAL A CA  1 
ATOM 1814  C C   . VAL A 1 247 ? 19.484  -15.443 -1.799  1.00 70.12  ? 241 VAL A C   1 
ATOM 1815  O O   . VAL A 1 247 ? 19.483  -15.313 -3.027  1.00 61.45  ? 241 VAL A O   1 
ATOM 1816  C CB  . VAL A 1 247 ? 17.493  -14.978 -0.266  1.00 60.91  ? 241 VAL A CB  1 
ATOM 1817  C CG1 . VAL A 1 247 ? 17.734  -13.556 -0.753  1.00 62.01  ? 241 VAL A CG1 1 
ATOM 1818  C CG2 . VAL A 1 247 ? 15.995  -15.256 -0.244  1.00 57.69  ? 241 VAL A CG2 1 
ATOM 1819  N N   . HIS A 1 248 ? 20.511  -15.072 -1.025  1.00 68.37  ? 242 HIS A N   1 
ATOM 1820  C CA  . HIS A 1 248 ? 21.680  -14.405 -1.572  1.00 68.17  ? 242 HIS A CA  1 
ATOM 1821  C C   . HIS A 1 248 ? 22.501  -15.384 -2.415  1.00 69.61  ? 242 HIS A C   1 
ATOM 1822  O O   . HIS A 1 248 ? 23.137  -14.979 -3.384  1.00 83.65  ? 242 HIS A O   1 
ATOM 1823  C CB  . HIS A 1 248 ? 22.438  -13.672 -0.456  1.00 68.49  ? 242 HIS A CB  1 
ATOM 1824  C CG  . HIS A 1 248 ? 21.803  -12.362 -0.131  1.00 66.41  ? 242 HIS A CG  1 
ATOM 1825  N ND1 . HIS A 1 248 ? 22.256  -11.166 -0.640  1.00 63.96  ? 242 HIS A ND1 1 
ATOM 1826  C CD2 . HIS A 1 248 ? 20.736  -12.064 0.612   1.00 69.91  ? 242 HIS A CD2 1 
ATOM 1827  C CE1 . HIS A 1 248 ? 21.479  -10.184 -0.213  1.00 66.74  ? 242 HIS A CE1 1 
ATOM 1828  N NE2 . HIS A 1 248 ? 20.545  -10.706 0.547   1.00 70.38  ? 242 HIS A NE2 1 
ATOM 1829  N N   . THR A 1 249 ? 22.462  -16.679 -2.084  1.00 64.61  ? 243 THR A N   1 
ATOM 1830  C CA  . THR A 1 249 ? 23.176  -17.654 -2.887  1.00 58.23  ? 243 THR A CA  1 
ATOM 1831  C C   . THR A 1 249 ? 22.489  -17.805 -4.236  1.00 60.78  ? 243 THR A C   1 
ATOM 1832  O O   . THR A 1 249 ? 23.149  -18.103 -5.221  1.00 73.52  ? 243 THR A O   1 
ATOM 1833  C CB  . THR A 1 249 ? 23.280  -18.994 -2.175  1.00 51.34  ? 243 THR A CB  1 
ATOM 1834  O OG1 . THR A 1 249 ? 24.005  -18.671 -0.990  1.00 51.94  ? 243 THR A OG1 1 
ATOM 1835  C CG2 . THR A 1 249 ? 24.011  -20.019 -3.022  1.00 48.80  ? 243 THR A CG2 1 
ATOM 1836  N N   . GLU A 1 250 ? 21.175  -17.601 -4.285  1.00 58.57  ? 244 GLU A N   1 
ATOM 1837  C CA  . GLU A 1 250 ? 20.459  -17.676 -5.549  1.00 63.92  ? 244 GLU A CA  1 
ATOM 1838  C C   . GLU A 1 250 ? 20.668  -16.408 -6.384  1.00 63.58  ? 244 GLU A C   1 
ATOM 1839  O O   . GLU A 1 250 ? 20.933  -16.484 -7.590  1.00 56.15  ? 244 GLU A O   1 
ATOM 1840  C CB  . GLU A 1 250 ? 18.965  -17.857 -5.289  1.00 71.57  ? 244 GLU A CB  1 
ATOM 1841  C CG  . GLU A 1 250 ? 18.592  -19.180 -4.630  1.00 70.04  ? 244 GLU A CG  1 
ATOM 1842  C CD  . GLU A 1 250 ? 17.128  -19.232 -4.230  1.00 68.76  ? 244 GLU A CD  1 
ATOM 1843  O OE1 . GLU A 1 250 ? 16.480  -18.179 -3.994  1.00 72.63  ? 244 GLU A OE1 1 
ATOM 1844  O OE2 . GLU A 1 250 ? 16.620  -20.365 -4.202  1.00 64.01  ? 244 GLU A OE2 1 
ATOM 1845  N N   . CYS A 1 251 ? 20.494  -15.239 -5.743  1.00 65.21  ? 245 CYS A N   1 
ATOM 1846  C CA  . CYS A 1 251 ? 20.623  -13.950 -6.414  1.00 60.52  ? 245 CYS A CA  1 
ATOM 1847  C C   . CYS A 1 251 ? 22.040  -13.808 -6.955  1.00 61.71  ? 245 CYS A C   1 
ATOM 1848  O O   . CYS A 1 251 ? 22.230  -13.207 -8.007  1.00 64.39  ? 245 CYS A O   1 
ATOM 1849  C CB  . CYS A 1 251 ? 20.235  -12.779 -5.513  1.00 56.28  ? 245 CYS A CB  1 
ATOM 1850  S SG  . CYS A 1 251 ? 18.442  -12.476 -5.407  1.00 56.98  ? 245 CYS A SG  1 
ATOM 1851  N N   . CYS A 1 252 ? 23.015  -14.481 -6.353  1.00 61.42  ? 246 CYS A N   1 
ATOM 1852  C CA  . CYS A 1 252 ? 24.391  -14.456 -6.914  1.00 66.07  ? 246 CYS A CA  1 
ATOM 1853  C C   . CYS A 1 252 ? 24.495  -15.464 -8.060  1.00 67.68  ? 246 CYS A C   1 
ATOM 1854  O O   . CYS A 1 252 ? 25.181  -15.145 -9.037  1.00 64.02  ? 246 CYS A O   1 
ATOM 1855  C CB  . CYS A 1 252 ? 25.387  -14.755 -5.815  1.00 79.77  ? 246 CYS A CB  1 
ATOM 1856  S SG  . CYS A 1 252 ? 25.321  -13.530 -4.488  1.00 123.56 ? 246 CYS A SG  1 
ATOM 1857  N N   . HIS A 1 253 ? 23.858  -16.626 -7.939  1.00 79.01  ? 247 HIS A N   1 
ATOM 1858  C CA  . HIS A 1 253 ? 23.749  -17.671 -9.007  1.00 77.91  ? 247 HIS A CA  1 
ATOM 1859  C C   . HIS A 1 253 ? 22.972  -17.003 -10.134 1.00 65.89  ? 247 HIS A C   1 
ATOM 1860  O O   . HIS A 1 253 ? 23.157  -17.301 -11.311 1.00 63.52  ? 247 HIS A O   1 
ATOM 1861  C CB  . HIS A 1 253 ? 23.296  -19.016 -8.438  1.00 80.29  ? 247 HIS A CB  1 
ATOM 1862  C CG  . HIS A 1 253 ? 24.374  -19.612 -7.602  1.00 89.70  ? 247 HIS A CG  1 
ATOM 1863  N ND1 . HIS A 1 253 ? 24.297  -20.838 -6.980  1.00 101.88 ? 247 HIS A ND1 1 
ATOM 1864  C CD2 . HIS A 1 253 ? 25.577  -19.113 -7.291  1.00 86.65  ? 247 HIS A CD2 1 
ATOM 1865  C CE1 . HIS A 1 253 ? 25.425  -21.060 -6.321  1.00 102.22 ? 247 HIS A CE1 1 
ATOM 1866  N NE2 . HIS A 1 253 ? 26.215  -20.023 -6.495  1.00 90.05  ? 247 HIS A NE2 1 
ATOM 1867  N N   . GLY A 1 254 ? 22.026  -16.181 -9.728  1.00 66.46  ? 248 GLY A N   1 
ATOM 1868  C CA  . GLY A 1 254 ? 21.303  -15.423 -10.743 1.00 74.99  ? 248 GLY A CA  1 
ATOM 1869  C C   . GLY A 1 254 ? 20.078  -16.059 -11.309 1.00 82.02  ? 248 GLY A C   1 
ATOM 1870  O O   . GLY A 1 254 ? 19.544  -15.525 -12.294 1.00 83.28  ? 248 GLY A O   1 
ATOM 1871  N N   . ASP A 1 255 ? 19.637  -17.179 -10.754 1.00 88.03  ? 249 ASP A N   1 
ATOM 1872  C CA  . ASP A 1 255 ? 18.387  -17.624 -11.400 1.00 94.90  ? 249 ASP A CA  1 
ATOM 1873  C C   . ASP A 1 255 ? 17.421  -16.475 -11.123 1.00 93.89  ? 249 ASP A C   1 
ATOM 1874  O O   . ASP A 1 255 ? 16.681  -16.150 -12.071 1.00 97.14  ? 249 ASP A O   1 
ATOM 1875  C CB  . ASP A 1 255 ? 17.977  -18.966 -10.816 1.00 98.86  ? 249 ASP A CB  1 
ATOM 1876  C CG  . ASP A 1 255 ? 18.966  -19.589 -9.841  1.00 98.71  ? 249 ASP A CG  1 
ATOM 1877  O OD1 . ASP A 1 255 ? 19.409  -18.875 -8.922  1.00 100.42 ? 249 ASP A OD1 1 
ATOM 1878  O OD2 . ASP A 1 255 ? 19.282  -20.783 -10.009 1.00 86.79  ? 249 ASP A OD2 1 
ATOM 1879  N N   . LEU A 1 256 ? 17.332  -15.918 -9.918  1.00 94.42  ? 250 LEU A N   1 
ATOM 1880  C CA  . LEU A 1 256 ? 16.752  -14.586 -9.597  1.00 98.92  ? 250 LEU A CA  1 
ATOM 1881  C C   . LEU A 1 256 ? 15.222  -14.472 -9.490  1.00 92.84  ? 250 LEU A C   1 
ATOM 1882  O O   . LEU A 1 256 ? 14.773  -13.398 -9.077  1.00 95.93  ? 250 LEU A O   1 
ATOM 1883  C CB  . LEU A 1 256 ? 17.280  -13.660 -10.693 1.00 30.00  ? 250 LEU A CB  1 
ATOM 1884  C CG  . LEU A 1 256 ? 17.553  -12.208 -10.299 1.00 30.00  ? 250 LEU A CG  1 
ATOM 1885  C CD1 . LEU A 1 256 ? 19.027  -11.990 -10.019 1.00 30.00  ? 250 LEU A CD1 1 
ATOM 1886  C CD2 . LEU A 1 256 ? 17.095  -11.314 -11.430 1.00 30.00  ? 250 LEU A CD2 1 
ATOM 1887  N N   . LEU A 1 257 ? 14.437  -15.511 -9.744  1.00 87.42  ? 251 LEU A N   1 
ATOM 1888  C CA  . LEU A 1 257 ? 12.986  -15.390 -9.476  1.00 89.51  ? 251 LEU A CA  1 
ATOM 1889  C C   . LEU A 1 257 ? 12.746  -16.022 -8.120  1.00 85.40  ? 251 LEU A C   1 
ATOM 1890  O O   . LEU A 1 257 ? 11.796  -15.649 -7.419  1.00 80.31  ? 251 LEU A O   1 
ATOM 1891  C CB  . LEU A 1 257 ? 12.236  -16.095 -10.596 1.00 30.00  ? 251 LEU A CB  1 
ATOM 1892  C CG  . LEU A 1 257 ? 11.969  -15.261 -11.851 1.00 30.00  ? 251 LEU A CG  1 
ATOM 1893  C CD1 . LEU A 1 257 ? 13.188  -15.244 -12.751 1.00 30.00  ? 251 LEU A CD1 1 
ATOM 1894  C CD2 . LEU A 1 257 ? 10.767  -15.792 -12.602 1.00 30.00  ? 251 LEU A CD2 1 
ATOM 1895  N N   . GLU A 1 258 ? 13.588  -16.997 -7.814  1.00 82.66  ? 252 GLU A N   1 
ATOM 1896  C CA  . GLU A 1 258 ? 13.499  -17.698 -6.529  1.00 76.42  ? 252 GLU A CA  1 
ATOM 1897  C C   . GLU A 1 258 ? 13.782  -16.732 -5.402  1.00 70.54  ? 252 GLU A C   1 
ATOM 1898  O O   . GLU A 1 258 ? 13.072  -16.761 -4.400  1.00 77.88  ? 252 GLU A O   1 
ATOM 1899  C CB  . GLU A 1 258 ? 14.594  -18.738 -6.690  1.00 84.59  ? 252 GLU A CB  1 
ATOM 1900  C CG  . GLU A 1 258 ? 14.235  -19.862 -7.658  1.00 85.78  ? 252 GLU A CG  1 
ATOM 1901  C CD  . GLU A 1 258 ? 14.870  -19.812 -9.036  1.00 85.44  ? 252 GLU A CD  1 
ATOM 1902  O OE1 . GLU A 1 258 ? 14.986  -18.703 -9.589  1.00 94.65  ? 252 GLU A OE1 1 
ATOM 1903  O OE2 . GLU A 1 258 ? 15.235  -20.881 -9.563  1.00 74.43  ? 252 GLU A OE2 1 
ATOM 1904  N N   . CYS A 1 259 ? 14.771  -15.875 -5.600  1.00 74.03  ? 253 CYS A N   1 
ATOM 1905  C CA  . CYS A 1 259 ? 15.160  -15.001 -4.485  1.00 76.33  ? 253 CYS A CA  1 
ATOM 1906  C C   . CYS A 1 259 ? 13.988  -14.119 -4.150  1.00 73.42  ? 253 CYS A C   1 
ATOM 1907  O O   . CYS A 1 259 ? 13.689  -13.940 -2.968  1.00 79.41  ? 253 CYS A O   1 
ATOM 1908  C CB  . CYS A 1 259 ? 15.987  -13.836 -4.967  1.00 73.78  ? 253 CYS A CB  1 
ATOM 1909  S SG  . CYS A 1 259 ? 17.602  -14.276 -5.624  1.00 89.03  ? 253 CYS A SG  1 
ATOM 1910  N N   . ALA A 1 260 ? 13.330  -13.636 -5.183  1.00 69.41  ? 254 ALA A N   1 
ATOM 1911  C CA  . ALA A 1 260 ? 12.245  -12.691 -4.912  1.00 71.98  ? 254 ALA A CA  1 
ATOM 1912  C C   . ALA A 1 260 ? 11.187  -13.507 -4.213  1.00 72.52  ? 254 ALA A C   1 
ATOM 1913  O O   . ALA A 1 260 ? 10.564  -13.037 -3.264  1.00 90.95  ? 254 ALA A O   1 
ATOM 1914  C CB  . ALA A 1 260 ? 11.741  -12.145 -6.201  1.00 76.28  ? 254 ALA A CB  1 
ATOM 1915  N N   . ASP A 1 261 ? 11.029  -14.728 -4.685  1.00 69.18  ? 255 ASP A N   1 
ATOM 1916  C CA  . ASP A 1 261 ? 10.034  -15.599 -4.080  1.00 68.07  ? 255 ASP A CA  1 
ATOM 1917  C C   . ASP A 1 261 ? 10.404  -15.901 -2.631  1.00 65.24  ? 255 ASP A C   1 
ATOM 1918  O O   . ASP A 1 261 ? 9.571   -15.739 -1.747  1.00 68.97  ? 255 ASP A O   1 
ATOM 1919  C CB  . ASP A 1 261 ? 9.883   -16.883 -4.879  1.00 67.29  ? 255 ASP A CB  1 
ATOM 1920  C CG  . ASP A 1 261 ? 8.494   -17.497 -4.881  1.00 65.90  ? 255 ASP A CG  1 
ATOM 1921  O OD1 . ASP A 1 261 ? 7.606   -16.974 -4.169  1.00 60.18  ? 255 ASP A OD1 1 
ATOM 1922  O OD2 . ASP A 1 261 ? 8.316   -18.482 -5.622  1.00 68.23  ? 255 ASP A OD2 1 
ATOM 1923  N N   . ASP A 1 262 ? 11.664  -16.298 -2.413  1.00 63.81  ? 256 ASP A N   1 
ATOM 1924  C CA  . ASP A 1 262 ? 12.163  -16.738 -1.120  1.00 66.62  ? 256 ASP A CA  1 
ATOM 1925  C C   . ASP A 1 262 ? 12.391  -15.597 -0.135  1.00 66.41  ? 256 ASP A C   1 
ATOM 1926  O O   . ASP A 1 262 ? 12.175  -15.785 1.063   1.00 78.01  ? 256 ASP A O   1 
ATOM 1927  C CB  . ASP A 1 262 ? 13.436  -17.532 -1.300  1.00 66.91  ? 256 ASP A CB  1 
ATOM 1928  C CG  . ASP A 1 262 ? 13.171  -18.810 -2.063  1.00 69.23  ? 256 ASP A CG  1 
ATOM 1929  O OD1 . ASP A 1 262 ? 11.972  -19.093 -2.281  1.00 62.13  ? 256 ASP A OD1 1 
ATOM 1930  O OD2 . ASP A 1 262 ? 14.148  -19.477 -2.435  1.00 80.60  ? 256 ASP A OD2 1 
ATOM 1931  N N   . ARG A 1 263 ? 12.866  -14.449 -0.622  1.00 60.05  ? 257 ARG A N   1 
ATOM 1932  C CA  . ARG A 1 263 ? 12.914  -13.253 0.204   1.00 58.49  ? 257 ARG A CA  1 
ATOM 1933  C C   . ARG A 1 263 ? 11.490  -12.862 0.603   1.00 51.06  ? 257 ARG A C   1 
ATOM 1934  O O   . ARG A 1 263 ? 11.264  -12.501 1.750   1.00 49.86  ? 257 ARG A O   1 
ATOM 1935  C CB  . ARG A 1 263 ? 13.666  -12.122 -0.501  1.00 63.26  ? 257 ARG A CB  1 
ATOM 1936  C CG  . ARG A 1 263 ? 13.855  -10.860 0.327   1.00 73.41  ? 257 ARG A CG  1 
ATOM 1937  C CD  . ARG A 1 263 ? 14.317  -9.721  -0.562  1.00 85.78  ? 257 ARG A CD  1 
ATOM 1938  N NE  . ARG A 1 263 ? 14.550  -8.444  0.125   1.00 101.56 ? 257 ARG A NE  1 
ATOM 1939  C CZ  . ARG A 1 263 ? 13.965  -7.279  -0.170  1.00 111.60 ? 257 ARG A CZ  1 
ATOM 1940  N NH1 . ARG A 1 263 ? 12.889  -7.222  -0.940  1.00 110.96 ? 257 ARG A NH1 1 
ATOM 1941  N NH2 . ARG A 1 263 ? 14.444  -6.158  0.340   1.00 123.85 ? 257 ARG A NH2 1 
ATOM 1942  N N   . ALA A 1 264 ? 10.522  -12.983 -0.315  1.00 50.37  ? 258 ALA A N   1 
ATOM 1943  C CA  . ALA A 1 264 ? 9.140   -12.632 -0.008  1.00 56.46  ? 258 ALA A CA  1 
ATOM 1944  C C   . ALA A 1 264 ? 8.592   -13.548 1.084   1.00 62.88  ? 258 ALA A C   1 
ATOM 1945  O O   . ALA A 1 264 ? 7.674   -13.164 1.803   1.00 65.08  ? 258 ALA A O   1 
ATOM 1946  C CB  . ALA A 1 264 ? 8.263   -12.674 -1.245  1.00 54.19  ? 258 ALA A CB  1 
ATOM 1947  N N   . ASP A 1 265 ? 9.163   -14.753 1.198   1.00 65.77  ? 259 ASP A N   1 
ATOM 1948  C CA  . ASP A 1 265 ? 8.775   -15.719 2.211   1.00 65.20  ? 259 ASP A CA  1 
ATOM 1949  C C   . ASP A 1 265 ? 9.486   -15.458 3.536   1.00 67.60  ? 259 ASP A C   1 
ATOM 1950  O O   . ASP A 1 265 ? 9.026   -15.946 4.565   1.00 74.46  ? 259 ASP A O   1 
ATOM 1951  C CB  . ASP A 1 265 ? 9.025   -17.133 1.721   1.00 70.64  ? 259 ASP A CB  1 
ATOM 1952  C CG  . ASP A 1 265 ? 8.098   -17.590 0.604   1.00 81.25  ? 259 ASP A CG  1 
ATOM 1953  O OD1 . ASP A 1 265 ? 7.130   -16.849 0.291   1.00 88.25  ? 259 ASP A OD1 1 
ATOM 1954  O OD2 . ASP A 1 265 ? 8.360   -18.676 0.049   1.00 88.36  ? 259 ASP A OD2 1 
ATOM 1955  N N   . LEU A 1 266 ? 10.609  -14.725 3.509   1.00 66.55  ? 260 LEU A N   1 
ATOM 1956  C CA  . LEU A 1 266 ? 11.285  -14.310 4.730   1.00 64.26  ? 260 LEU A CA  1 
ATOM 1957  C C   . LEU A 1 266 ? 10.491  -13.198 5.399   1.00 70.18  ? 260 LEU A C   1 
ATOM 1958  O O   . LEU A 1 266 ? 10.085  -13.345 6.545   1.00 90.34  ? 260 LEU A O   1 
ATOM 1959  C CB  . LEU A 1 266 ? 12.720  -13.850 4.498   1.00 62.56  ? 260 LEU A CB  1 
ATOM 1960  C CG  . LEU A 1 266 ? 13.815  -14.832 4.903   1.00 62.09  ? 260 LEU A CG  1 
ATOM 1961  C CD1 . LEU A 1 266 ? 15.164  -14.162 4.788   1.00 58.82  ? 260 LEU A CD1 1 
ATOM 1962  C CD2 . LEU A 1 266 ? 13.572  -15.357 6.313   1.00 66.20  ? 260 LEU A CD2 1 
ATOM 1963  N N   . ALA A 1 267 ? 10.315  -12.080 4.689   1.00 67.32  ? 261 ALA A N   1 
ATOM 1964  C CA  . ALA A 1 267 ? 9.446   -11.010 5.146   1.00 69.38  ? 261 ALA A CA  1 
ATOM 1965  C C   . ALA A 1 267 ? 8.128   -11.584 5.685   1.00 71.57  ? 261 ALA A C   1 
ATOM 1966  O O   . ALA A 1 267 ? 7.772   -11.276 6.818   1.00 77.76  ? 261 ALA A O   1 
ATOM 1967  C CB  . ALA A 1 267 ? 9.220   -10.030 4.011   1.00 75.16  ? 261 ALA A CB  1 
ATOM 1968  N N   . LYS A 1 268 ? 7.430   -12.419 4.884   1.00 72.15  ? 262 LYS A N   1 
ATOM 1969  C CA  . LYS A 1 268 ? 6.185   -13.078 5.268   1.00 69.09  ? 262 LYS A CA  1 
ATOM 1970  C C   . LYS A 1 268 ? 6.351   -13.700 6.652   1.00 72.35  ? 262 LYS A C   1 
ATOM 1971  O O   . LYS A 1 268 ? 5.528   -13.468 7.535   1.00 79.29  ? 262 LYS A O   1 
ATOM 1972  C CB  . LYS A 1 268 ? 5.748   -14.226 4.342   1.00 73.86  ? 262 LYS A CB  1 
ATOM 1973  C CG  . LYS A 1 268 ? 5.118   -13.895 2.977   1.00 85.84  ? 262 LYS A CG  1 
ATOM 1974  C CD  . LYS A 1 268 ? 4.700   -15.116 2.140   1.00 91.65  ? 262 LYS A CD  1 
ATOM 1975  C CE  . LYS A 1 268 ? 4.753   -15.004 0.621   1.00 84.31  ? 262 LYS A CE  1 
ATOM 1976  N NZ  . LYS A 1 268 ? 4.108   -13.816 0.057   1.00 84.25  ? 262 LYS A NZ  1 
ATOM 1977  N N   . TYR A 1 269 ? 7.429   -14.482 6.811   1.00 71.22  ? 263 TYR A N   1 
ATOM 1978  C CA  . TYR A 1 269 ? 7.726   -15.235 8.024   1.00 69.55  ? 263 TYR A CA  1 
ATOM 1979  C C   . TYR A 1 269 ? 7.995   -14.317 9.219   1.00 69.19  ? 263 TYR A C   1 
ATOM 1980  O O   . TYR A 1 269 ? 7.424   -14.507 10.293  1.00 70.95  ? 263 TYR A O   1 
ATOM 1981  C CB  . TYR A 1 269 ? 8.955   -16.111 7.761   1.00 70.15  ? 263 TYR A CB  1 
ATOM 1982  C CG  . TYR A 1 269 ? 9.488   -16.792 9.009   1.00 73.99  ? 263 TYR A CG  1 
ATOM 1983  C CD1 . TYR A 1 269 ? 8.813   -17.880 9.550   1.00 76.50  ? 263 TYR A CD1 1 
ATOM 1984  C CD2 . TYR A 1 269 ? 10.644  -16.348 9.647   1.00 78.84  ? 263 TYR A CD2 1 
ATOM 1985  C CE1 . TYR A 1 269 ? 9.264   -18.509 10.695  1.00 73.95  ? 263 TYR A CE1 1 
ATOM 1986  C CE2 . TYR A 1 269 ? 11.113  -16.976 10.789  1.00 80.89  ? 263 TYR A CE2 1 
ATOM 1987  C CZ  . TYR A 1 269 ? 10.417  -18.055 11.307  1.00 78.78  ? 263 TYR A CZ  1 
ATOM 1988  O OH  . TYR A 1 269 ? 10.842  -18.693 12.425  1.00 90.91  ? 263 TYR A OH  1 
ATOM 1989  N N   . ILE A 1 270 ? 8.901   -13.350 9.020   1.00 65.10  ? 264 ILE A N   1 
ATOM 1990  C CA  . ILE A 1 270 ? 9.332   -12.405 10.039  1.00 62.86  ? 264 ILE A CA  1 
ATOM 1991  C C   . ILE A 1 270 ? 8.152   -11.572 10.543  1.00 59.94  ? 264 ILE A C   1 
ATOM 1992  O O   . ILE A 1 270 ? 8.046   -11.323 11.746  1.00 49.21  ? 264 ILE A O   1 
ATOM 1993  C CB  . ILE A 1 270 ? 10.451  -11.514 9.469   1.00 63.04  ? 264 ILE A CB  1 
ATOM 1994  C CG1 . ILE A 1 270 ? 11.744  -12.311 9.230   1.00 60.56  ? 264 ILE A CG1 1 
ATOM 1995  C CG2 . ILE A 1 270 ? 10.700  -10.305 10.368  1.00 63.06  ? 264 ILE A CG2 1 
ATOM 1996  C CD1 . ILE A 1 270 ? 12.652  -11.707 8.170   1.00 60.37  ? 264 ILE A CD1 1 
ATOM 1997  N N   . CYS A 1 271 ? 7.300   -11.123 9.609   1.00 63.72  ? 265 CYS A N   1 
ATOM 1998  C CA  . CYS A 1 271 ? 6.083   -10.393 9.938   1.00 72.21  ? 265 CYS A CA  1 
ATOM 1999  C C   . CYS A 1 271 ? 5.243   -11.195 10.921  1.00 66.60  ? 265 CYS A C   1 
ATOM 2000  O O   . CYS A 1 271 ? 4.739   -10.645 11.893  1.00 67.17  ? 265 CYS A O   1 
ATOM 2001  C CB  . CYS A 1 271 ? 5.221   -10.090 8.713   1.00 82.89  ? 265 CYS A CB  1 
ATOM 2002  S SG  . CYS A 1 271 ? 5.849   -8.741  7.675   1.00 96.64  ? 265 CYS A SG  1 
ATOM 2003  N N   . GLU A 1 272 ? 5.107   -12.496 10.656  1.00 66.73  ? 266 GLU A N   1 
ATOM 2004  C CA  . GLU A 1 272 ? 4.241   -13.352 11.446  1.00 68.61  ? 266 GLU A CA  1 
ATOM 2005  C C   . GLU A 1 272 ? 4.879   -13.683 12.792  1.00 62.45  ? 266 GLU A C   1 
ATOM 2006  O O   . GLU A 1 272 ? 4.145   -14.006 13.716  1.00 63.45  ? 266 GLU A O   1 
ATOM 2007  C CB  . GLU A 1 272 ? 3.886   -14.624 10.678  1.00 81.95  ? 266 GLU A CB  1 
ATOM 2008  C CG  . GLU A 1 272 ? 3.042   -14.369 9.428   1.00 90.21  ? 266 GLU A CG  1 
ATOM 2009  C CD  . GLU A 1 272 ? 2.636   -15.634 8.683   1.00 88.46  ? 266 GLU A CD  1 
ATOM 2010  O OE1 . GLU A 1 272 ? 3.531   -16.494 8.529   1.00 83.35  ? 266 GLU A OE1 1 
ATOM 2011  O OE2 . GLU A 1 272 ? 1.457   -15.772 8.265   1.00 84.89  ? 266 GLU A OE2 1 
ATOM 2012  N N   . ASN A 1 273 ? 6.216   -13.581 12.903  1.00 65.43  ? 267 ASN A N   1 
ATOM 2013  C CA  . ASN A 1 273 ? 6.943   -13.906 14.129  1.00 66.04  ? 267 ASN A CA  1 
ATOM 2014  C C   . ASN A 1 273 ? 7.685   -12.693 14.703  1.00 62.62  ? 267 ASN A C   1 
ATOM 2015  O O   . ASN A 1 273 ? 8.748   -12.831 15.308  1.00 53.10  ? 267 ASN A O   1 
ATOM 2016  C CB  . ASN A 1 273 ? 7.975   -15.012 13.915  1.00 67.34  ? 267 ASN A CB  1 
ATOM 2017  C CG  . ASN A 1 273 ? 7.384   -16.313 13.431  1.00 65.65  ? 267 ASN A CG  1 
ATOM 2018  O OD1 . ASN A 1 273 ? 6.222   -16.350 13.023  1.00 68.66  ? 267 ASN A OD1 1 
ATOM 2019  N ND2 . ASN A 1 273 ? 8.175   -17.377 13.433  1.00 66.63  ? 267 ASN A ND2 1 
ATOM 2020  N N   . GLN A 1 274 ? 7.112   -11.498 14.563  1.00 68.47  ? 268 GLN A N   1 
ATOM 2021  C CA  . GLN A 1 274 ? 7.738   -10.303 15.112  1.00 75.05  ? 268 GLN A CA  1 
ATOM 2022  C C   . GLN A 1 274 ? 8.061   -10.493 16.591  1.00 76.21  ? 268 GLN A C   1 
ATOM 2023  O O   . GLN A 1 274 ? 9.149   -10.137 17.050  1.00 65.58  ? 268 GLN A O   1 
ATOM 2024  C CB  . GLN A 1 274 ? 6.813   -9.090  15.065  1.00 75.04  ? 268 GLN A CB  1 
ATOM 2025  C CG  . GLN A 1 274 ? 6.462   -8.633  13.658  1.00 76.10  ? 268 GLN A CG  1 
ATOM 2026  C CD  . GLN A 1 274 ? 5.405   -7.559  13.675  1.00 70.52  ? 268 GLN A CD  1 
ATOM 2027  O OE1 . GLN A 1 274 ? 5.671   -6.428  14.094  1.00 63.77  ? 268 GLN A OE1 1 
ATOM 2028  N NE2 . GLN A 1 274 ? 4.200   -7.914  13.246  1.00 72.59  ? 268 GLN A NE2 1 
ATOM 2029  N N   . ASP A 1 275 ? 7.082   -11.041 17.323  1.00 81.37  ? 269 ASP A N   1 
ATOM 2030  C CA  . ASP A 1 275 ? 7.079   -10.959 18.772  1.00 80.55  ? 269 ASP A CA  1 
ATOM 2031  C C   . ASP A 1 275 ? 8.287   -11.716 19.313  1.00 73.61  ? 269 ASP A C   1 
ATOM 2032  O O   . ASP A 1 275 ? 8.822   -11.341 20.356  1.00 80.57  ? 269 ASP A O   1 
ATOM 2033  C CB  . ASP A 1 275 ? 5.723   -11.336 19.356  1.00 81.25  ? 269 ASP A CB  1 
ATOM 2034  C CG  . ASP A 1 275 ? 4.524   -10.540 18.843  1.00 81.92  ? 269 ASP A CG  1 
ATOM 2035  O OD1 . ASP A 1 275 ? 4.657   -9.919  17.769  1.00 87.94  ? 269 ASP A OD1 1 
ATOM 2036  O OD2 . ASP A 1 275 ? 3.456   -10.544 19.510  1.00 70.82  ? 269 ASP A OD2 1 
ATOM 2037  N N   . SER A 1 276 ? 8.748   -12.731 18.572  1.00 62.98  ? 270 SER A N   1 
ATOM 2038  C CA  . SER A 1 276 ? 9.918   -13.476 18.998  1.00 70.82  ? 270 SER A CA  1 
ATOM 2039  C C   . SER A 1 276 ? 11.170  -13.019 18.248  1.00 69.08  ? 270 SER A C   1 
ATOM 2040  O O   . SER A 1 276 ? 12.142  -13.769 18.170  1.00 73.61  ? 270 SER A O   1 
ATOM 2041  C CB  . SER A 1 276 ? 9.686   -14.952 18.845  1.00 79.51  ? 270 SER A CB  1 
ATOM 2042  O OG  . SER A 1 276 ? 9.701   -15.344 17.480  1.00 100.22 ? 270 SER A OG  1 
ATOM 2043  N N   . ILE A 1 277 ? 11.169  -11.782 17.733  1.00 66.03  ? 271 ILE A N   1 
ATOM 2044  C CA  . ILE A 1 277 ? 12.261  -11.302 16.894  1.00 62.61  ? 271 ILE A CA  1 
ATOM 2045  C C   . ILE A 1 277 ? 12.642  -9.863  17.273  1.00 61.42  ? 271 ILE A C   1 
ATOM 2046  O O   . ILE A 1 277 ? 13.749  -9.602  17.778  1.00 53.64  ? 271 ILE A O   1 
ATOM 2047  C CB  . ILE A 1 277 ? 11.862  -11.439 15.412  1.00 58.51  ? 271 ILE A CB  1 
ATOM 2048  C CG1 . ILE A 1 277 ? 11.616  -12.886 15.024  1.00 49.27  ? 271 ILE A CG1 1 
ATOM 2049  C CG2 . ILE A 1 277 ? 12.901  -10.790 14.497  1.00 64.66  ? 271 ILE A CG2 1 
ATOM 2050  C CD1 . ILE A 1 277 ? 11.055  -13.047 13.630  1.00 46.99  ? 271 ILE A CD1 1 
ATOM 2051  N N   . SER A 1 278 ? 11.723  -8.919  17.006  1.00 59.77  ? 272 SER A N   1 
ATOM 2052  C CA  . SER A 1 278 ? 11.958  -7.524  17.342  1.00 63.61  ? 272 SER A CA  1 
ATOM 2053  C C   . SER A 1 278 ? 10.632  -6.801  17.572  1.00 62.23  ? 272 SER A C   1 
ATOM 2054  O O   . SER A 1 278 ? 9.630   -7.092  16.915  1.00 54.36  ? 272 SER A O   1 
ATOM 2055  C CB  . SER A 1 278 ? 12.801  -6.824  16.284  1.00 65.03  ? 272 SER A CB  1 
ATOM 2056  O OG  . SER A 1 278 ? 13.341  -5.590  16.757  1.00 62.98  ? 272 SER A OG  1 
ATOM 2057  N N   . SER A 1 279 ? 10.669  -5.840  18.506  1.00 64.02  ? 273 SER A N   1 
ATOM 2058  C CA  . SER A 1 279 ? 9.577   -4.908  18.740  1.00 66.30  ? 273 SER A CA  1 
ATOM 2059  C C   . SER A 1 279 ? 9.631   -3.739  17.754  1.00 69.21  ? 273 SER A C   1 
ATOM 2060  O O   . SER A 1 279 ? 8.848   -2.808  17.868  1.00 82.37  ? 273 SER A O   1 
ATOM 2061  C CB  . SER A 1 279 ? 9.602   -4.415  20.169  1.00 66.04  ? 273 SER A CB  1 
ATOM 2062  O OG  . SER A 1 279 ? 10.915  -4.038  20.565  1.00 66.18  ? 273 SER A OG  1 
ATOM 2063  N N   . LYS A 1 280 ? 10.532  -3.794  16.772  1.00 66.40  ? 274 LYS A N   1 
ATOM 2064  C CA  . LYS A 1 280 ? 10.706  -2.703  15.835  1.00 66.55  ? 274 LYS A CA  1 
ATOM 2065  C C   . LYS A 1 280 ? 9.971   -2.968  14.524  1.00 68.50  ? 274 LYS A C   1 
ATOM 2066  O O   . LYS A 1 280 ? 9.911   -2.108  13.658  1.00 79.66  ? 274 LYS A O   1 
ATOM 2067  C CB  . LYS A 1 280 ? 12.205  -2.556  15.575  1.00 68.05  ? 274 LYS A CB  1 
ATOM 2068  C CG  . LYS A 1 280 ? 13.023  -2.319  16.821  1.00 66.92  ? 274 LYS A CG  1 
ATOM 2069  C CD  . LYS A 1 280 ? 12.574  -1.084  17.583  1.00 67.85  ? 274 LYS A CD  1 
ATOM 2070  C CE  . LYS A 1 280 ? 13.503  -0.768  18.713  1.00 73.38  ? 274 LYS A CE  1 
ATOM 2071  N NZ  . LYS A 1 280 ? 13.011  0.304   19.584  1.00 73.49  ? 274 LYS A NZ  1 
ATOM 2072  N N   . LEU A 1 281 ? 9.382   -4.145  14.367  1.00 71.41  ? 275 LEU A N   1 
ATOM 2073  C CA  . LEU A 1 281 ? 8.965   -4.556  13.041  1.00 80.84  ? 275 LEU A CA  1 
ATOM 2074  C C   . LEU A 1 281 ? 7.501   -4.204  12.790  1.00 92.26  ? 275 LEU A C   1 
ATOM 2075  O O   . LEU A 1 281 ? 6.985   -4.497  11.709  1.00 95.12  ? 275 LEU A O   1 
ATOM 2076  C CB  . LEU A 1 281 ? 9.262   -6.048  12.920  1.00 82.98  ? 275 LEU A CB  1 
ATOM 2077  C CG  . LEU A 1 281 ? 10.756  -6.400  12.901  1.00 84.98  ? 275 LEU A CG  1 
ATOM 2078  C CD1 . LEU A 1 281 ? 11.067  -7.799  13.408  1.00 82.64  ? 275 LEU A CD1 1 
ATOM 2079  C CD2 . LEU A 1 281 ? 11.301  -6.226  11.490  1.00 85.32  ? 275 LEU A CD2 1 
ATOM 2080  N N   . LYS A 1 282 ? 6.849   -3.548  13.762  1.00 89.38  ? 276 LYS A N   1 
ATOM 2081  C CA  . LYS A 1 282 ? 5.421   -3.310  13.655  1.00 93.02  ? 276 LYS A CA  1 
ATOM 2082  C C   . LYS A 1 282 ? 5.171   -2.444  12.425  1.00 89.83  ? 276 LYS A C   1 
ATOM 2083  O O   . LYS A 1 282 ? 4.453   -2.851  11.510  1.00 88.79  ? 276 LYS A O   1 
ATOM 2084  C CB  . LYS A 1 282 ? 4.835   -2.687  14.929  1.00 106.07 ? 276 LYS A CB  1 
ATOM 2085  C CG  . LYS A 1 282 ? 3.298   -2.624  14.965  1.00 109.56 ? 276 LYS A CG  1 
ATOM 2086  C CD  . LYS A 1 282 ? 2.699   -1.622  15.947  1.00 104.00 ? 276 LYS A CD  1 
ATOM 2087  C CE  . LYS A 1 282 ? 1.239   -1.367  15.709  1.00 101.49 ? 276 LYS A CE  1 
ATOM 2088  N NZ  . LYS A 1 282 ? 0.823   -0.063  16.236  1.00 103.17 ? 276 LYS A NZ  1 
ATOM 2089  N N   . GLU A 1 283 ? 5.805   -1.267  12.400  1.00 87.76  ? 277 GLU A N   1 
ATOM 2090  C CA  . GLU A 1 283 ? 5.490   -0.267  11.391  1.00 90.02  ? 277 GLU A CA  1 
ATOM 2091  C C   . GLU A 1 283 ? 5.836   -0.827  10.012  1.00 89.51  ? 277 GLU A C   1 
ATOM 2092  O O   . GLU A 1 283 ? 5.120   -0.559  9.049   1.00 93.75  ? 277 GLU A O   1 
ATOM 2093  C CB  . GLU A 1 283 ? 6.088   1.087   11.789  1.00 84.27  ? 277 GLU A CB  1 
ATOM 2094  C CG  . GLU A 1 283 ? 5.227   1.801   12.830  1.00 83.40  ? 277 GLU A CG  1 
ATOM 2095  C CD  . GLU A 1 283 ? 5.890   2.788   13.776  1.00 95.19  ? 277 GLU A CD  1 
ATOM 2096  O OE1 . GLU A 1 283 ? 7.072   3.133   13.567  1.00 114.05 ? 277 GLU A OE1 1 
ATOM 2097  O OE2 . GLU A 1 283 ? 5.215   3.199   14.752  1.00 96.83  ? 277 GLU A OE2 1 
ATOM 2098  N N   . CYS A 1 284 ? 6.881   -1.663  9.948   1.00 83.01  ? 278 CYS A N   1 
ATOM 2099  C CA  . CYS A 1 284 ? 7.378   -2.193  8.689   1.00 78.12  ? 278 CYS A CA  1 
ATOM 2100  C C   . CYS A 1 284 ? 6.451   -3.265  8.138   1.00 76.54  ? 278 CYS A C   1 
ATOM 2101  O O   . CYS A 1 284 ? 6.283   -3.363  6.926   1.00 97.20  ? 278 CYS A O   1 
ATOM 2102  C CB  . CYS A 1 284 ? 8.737   -2.849  8.863   1.00 80.32  ? 278 CYS A CB  1 
ATOM 2103  S SG  . CYS A 1 284 ? 9.751   -2.015  10.108  1.00 91.47  ? 278 CYS A SG  1 
ATOM 2104  N N   . CYS A 1 285 ? 5.862   -4.072  9.024   1.00 65.80  ? 279 CYS A N   1 
ATOM 2105  C CA  . CYS A 1 285 ? 5.151   -5.262  8.587   1.00 66.44  ? 279 CYS A CA  1 
ATOM 2106  C C   . CYS A 1 285 ? 3.690   -4.946  8.256   1.00 67.35  ? 279 CYS A C   1 
ATOM 2107  O O   . CYS A 1 285 ? 2.912   -5.866  8.011   1.00 65.98  ? 279 CYS A O   1 
ATOM 2108  C CB  . CYS A 1 285 ? 5.305   -6.379  9.615   1.00 73.00  ? 279 CYS A CB  1 
ATOM 2109  S SG  . CYS A 1 285 ? 6.982   -7.079  9.710   1.00 72.14  ? 279 CYS A SG  1 
ATOM 2110  N N   . GLU A 1 286 ? 3.321   -3.655  8.255   1.00 72.91  ? 280 GLU A N   1 
ATOM 2111  C CA  . GLU A 1 286 ? 2.023   -3.207  7.769   1.00 72.93  ? 280 GLU A CA  1 
ATOM 2112  C C   . GLU A 1 286 ? 2.121   -2.750  6.321   1.00 72.26  ? 280 GLU A C   1 
ATOM 2113  O O   . GLU A 1 286 ? 1.118   -2.741  5.614   1.00 78.02  ? 280 GLU A O   1 
ATOM 2114  C CB  . GLU A 1 286 ? 1.522   -2.029  8.594   1.00 75.99  ? 280 GLU A CB  1 
ATOM 2115  C CG  . GLU A 1 286 ? 1.211   -2.436  10.030  1.00 88.42  ? 280 GLU A CG  1 
ATOM 2116  C CD  . GLU A 1 286 ? 1.714   -1.468  11.082  1.00 95.06  ? 280 GLU A CD  1 
ATOM 2117  O OE1 . GLU A 1 286 ? 2.274   -0.402  10.721  1.00 89.32  ? 280 GLU A OE1 1 
ATOM 2118  O OE2 . GLU A 1 286 ? 1.549   -1.816  12.276  1.00 96.55  ? 280 GLU A OE2 1 
ATOM 2119  N N   . LYS A 1 287 ? 3.338   -2.382  5.898   1.00 70.84  ? 281 LYS A N   1 
ATOM 2120  C CA  . LYS A 1 287 ? 3.577   -1.801  4.585   1.00 69.73  ? 281 LYS A CA  1 
ATOM 2121  C C   . LYS A 1 287 ? 3.417   -2.864  3.492   1.00 72.16  ? 281 LYS A C   1 
ATOM 2122  O O   . LYS A 1 287 ? 3.554   -4.057  3.755   1.00 70.23  ? 281 LYS A O   1 
ATOM 2123  C CB  . LYS A 1 287 ? 4.959   -1.136  4.573   1.00 65.11  ? 281 LYS A CB  1 
ATOM 2124  C CG  . LYS A 1 287 ? 5.192   -0.063  5.637   1.00 67.33  ? 281 LYS A CG  1 
ATOM 2125  C CD  . LYS A 1 287 ? 4.202   1.098   5.634   1.00 73.85  ? 281 LYS A CD  1 
ATOM 2126  C CE  . LYS A 1 287 ? 4.301   2.033   6.814   1.00 73.31  ? 281 LYS A CE  1 
ATOM 2127  N NZ  . LYS A 1 287 ? 5.594   2.721   6.823   1.00 78.55  ? 281 LYS A NZ  1 
ATOM 2128  N N   . PRO A 1 288 ? 3.111   -2.466  2.229   1.00 74.28  ? 282 PRO A N   1 
ATOM 2129  C CA  . PRO A 1 288 ? 2.824   -3.416  1.149   1.00 71.80  ? 282 PRO A CA  1 
ATOM 2130  C C   . PRO A 1 288 ? 4.003   -4.354  0.924   1.00 78.49  ? 282 PRO A C   1 
ATOM 2131  O O   . PRO A 1 288 ? 5.083   -4.110  1.455   1.00 87.53  ? 282 PRO A O   1 
ATOM 2132  C CB  . PRO A 1 288 ? 2.565   -2.539  -0.092  1.00 70.98  ? 282 PRO A CB  1 
ATOM 2133  C CG  . PRO A 1 288 ? 2.326   -1.145  0.443   1.00 70.68  ? 282 PRO A CG  1 
ATOM 2134  C CD  . PRO A 1 288 ? 3.050   -1.066  1.773   1.00 75.36  ? 282 PRO A CD  1 
ATOM 2135  N N   . LEU A 1 289 ? 3.807   -5.382  0.089   1.00 77.35  ? 283 LEU A N   1 
ATOM 2136  C CA  . LEU A 1 289 ? 4.756   -6.485  0.010   1.00 80.63  ? 283 LEU A CA  1 
ATOM 2137  C C   . LEU A 1 289 ? 6.146   -5.991  -0.392  1.00 80.54  ? 283 LEU A C   1 
ATOM 2138  O O   . LEU A 1 289 ? 7.150   -6.484  0.125   1.00 78.11  ? 283 LEU A O   1 
ATOM 2139  C CB  . LEU A 1 289 ? 4.271   -7.582  -0.936  1.00 83.80  ? 283 LEU A CB  1 
ATOM 2140  C CG  . LEU A 1 289 ? 5.124   -8.859  -1.019  1.00 92.95  ? 283 LEU A CG  1 
ATOM 2141  C CD1 . LEU A 1 289 ? 6.407   -8.733  -1.853  1.00 84.56  ? 283 LEU A CD1 1 
ATOM 2142  C CD2 . LEU A 1 289 ? 5.456   -9.404  0.380   1.00 100.26 ? 283 LEU A CD2 1 
ATOM 2143  N N   . LEU A 1 290 ? 6.224   -5.035  -1.321  1.00 78.63  ? 284 LEU A N   1 
ATOM 2144  C CA  . LEU A 1 290 ? 7.528   -4.656  -1.839  1.00 75.47  ? 284 LEU A CA  1 
ATOM 2145  C C   . LEU A 1 290 ? 8.268   -3.819  -0.789  1.00 77.66  ? 284 LEU A C   1 
ATOM 2146  O O   . LEU A 1 290 ? 9.432   -4.113  -0.486  1.00 64.53  ? 284 LEU A O   1 
ATOM 2147  C CB  . LEU A 1 290 ? 7.402   -3.926  -3.175  1.00 73.44  ? 284 LEU A CB  1 
ATOM 2148  C CG  . LEU A 1 290 ? 8.406   -4.326  -4.264  1.00 66.10  ? 284 LEU A CG  1 
ATOM 2149  C CD1 . LEU A 1 290 ? 9.738   -4.820  -3.720  1.00 70.99  ? 284 LEU A CD1 1 
ATOM 2150  C CD2 . LEU A 1 290 ? 7.799   -5.376  -5.155  1.00 63.02  ? 284 LEU A CD2 1 
ATOM 2151  N N   . GLU A 1 291 ? 7.546   -2.874  -0.191  1.00 80.31  ? 285 GLU A N   1 
ATOM 2152  C CA  . GLU A 1 291 ? 8.144   -1.941  0.790   1.00 80.76  ? 285 GLU A CA  1 
ATOM 2153  C C   . GLU A 1 291 ? 8.528   -2.649  2.082   1.00 81.65  ? 285 GLU A C   1 
ATOM 2154  O O   . GLU A 1 291 ? 9.571   -2.294  2.655   1.00 87.30  ? 285 GLU A O   1 
ATOM 2155  C CB  . GLU A 1 291 ? 7.059   -0.916  1.100   1.00 79.05  ? 285 GLU A CB  1 
ATOM 2156  C CG  . GLU A 1 291 ? 7.580   0.411   1.640   1.00 88.31  ? 285 GLU A CG  1 
ATOM 2157  C CD  . GLU A 1 291 ? 6.475   1.447   1.727   1.00 96.89  ? 285 GLU A CD  1 
ATOM 2158  O OE1 . GLU A 1 291 ? 6.647   2.460   2.433   1.00 92.87  ? 285 GLU A OE1 1 
ATOM 2159  O OE2 . GLU A 1 291 ? 5.430   1.234   1.082   1.00 106.14 ? 285 GLU A OE2 1 
ATOM 2160  N N   . LYS A 1 292 ? 7.758   -3.644  2.498   1.00 77.01  ? 286 LYS A N   1 
ATOM 2161  C CA  . LYS A 1 292 ? 8.018   -4.247  3.821   1.00 70.42  ? 286 LYS A CA  1 
ATOM 2162  C C   . LYS A 1 292 ? 9.401   -4.874  3.836   1.00 61.38  ? 286 LYS A C   1 
ATOM 2163  O O   . LYS A 1 292 ? 10.127  -4.688  4.812   1.00 53.13  ? 286 LYS A O   1 
ATOM 2164  C CB  . LYS A 1 292 ? 6.913   -5.290  3.981   1.00 74.97  ? 286 LYS A CB  1 
ATOM 2165  C CG  . LYS A 1 292 ? 7.272   -6.642  4.556   1.00 84.16  ? 286 LYS A CG  1 
ATOM 2166  C CD  . LYS A 1 292 ? 6.140   -7.630  4.308   1.00 96.62  ? 286 LYS A CD  1 
ATOM 2167  C CE  . LYS A 1 292 ? 4.888   -6.939  3.875   1.00 101.14 ? 286 LYS A CE  1 
ATOM 2168  N NZ  . LYS A 1 292 ? 3.695   -7.775  4.026   1.00 99.59  ? 286 LYS A NZ  1 
ATOM 2169  N N   . SER A 1 293 ? 9.762   -5.536  2.757   1.00 65.67  ? 287 SER A N   1 
ATOM 2170  C CA  . SER A 1 293 ? 11.058  -6.239  2.746   1.00 76.70  ? 287 SER A CA  1 
ATOM 2171  C C   . SER A 1 293 ? 12.213  -5.244  2.888   1.00 78.23  ? 287 SER A C   1 
ATOM 2172  O O   . SER A 1 293 ? 13.177  -5.539  3.613   1.00 75.19  ? 287 SER A O   1 
ATOM 2173  C CB  . SER A 1 293 ? 11.168  -7.039  1.497   1.00 79.13  ? 287 SER A CB  1 
ATOM 2174  O OG  . SER A 1 293 ? 10.084  -6.760  0.623   1.00 89.58  ? 287 SER A OG  1 
ATOM 2175  N N   . HIS A 1 294 ? 12.120  -4.112  2.204   1.00 80.24  ? 288 HIS A N   1 
ATOM 2176  C CA  . HIS A 1 294 ? 13.179  -3.085  2.325   1.00 80.80  ? 288 HIS A CA  1 
ATOM 2177  C C   . HIS A 1 294 ? 13.239  -2.553  3.753   1.00 82.16  ? 288 HIS A C   1 
ATOM 2178  O O   . HIS A 1 294 ? 14.344  -2.347  4.271   1.00 92.41  ? 288 HIS A O   1 
ATOM 2179  C CB  . HIS A 1 294 ? 12.918  -1.961  1.324   1.00 80.00  ? 288 HIS A CB  1 
ATOM 2180  C CG  . HIS A 1 294 ? 13.899  -0.845  1.368   1.00 81.04  ? 288 HIS A CG  1 
ATOM 2181  N ND1 . HIS A 1 294 ? 15.216  -0.992  0.995   1.00 91.77  ? 288 HIS A ND1 1 
ATOM 2182  C CD2 . HIS A 1 294 ? 13.756  0.431   1.729   1.00 77.31  ? 288 HIS A CD2 1 
ATOM 2183  C CE1 . HIS A 1 294 ? 15.839  0.165   1.140   1.00 86.90  ? 288 HIS A CE1 1 
ATOM 2184  N NE2 . HIS A 1 294 ? 14.971  1.043   1.584   1.00 82.05  ? 288 HIS A NE2 1 
ATOM 2185  N N   . CYS A 1 295 ? 12.083  -2.321  4.366   1.00 83.07  ? 289 CYS A N   1 
ATOM 2186  C CA  . CYS A 1 295 ? 12.048  -1.724  5.728   1.00 84.71  ? 289 CYS A CA  1 
ATOM 2187  C C   . CYS A 1 295 ? 12.706  -2.650  6.754   1.00 72.12  ? 289 CYS A C   1 
ATOM 2188  O O   . CYS A 1 295 ? 13.466  -2.155  7.594   1.00 65.02  ? 289 CYS A O   1 
ATOM 2189  C CB  . CYS A 1 295 ? 10.621  -1.374  6.123   1.00 94.61  ? 289 CYS A CB  1 
ATOM 2190  S SG  . CYS A 1 295 ? 10.334  0.405   6.301   1.00 106.00 ? 289 CYS A SG  1 
ATOM 2191  N N   . ILE A 1 296 ? 12.457  -3.944  6.642   1.00 63.57  ? 290 ILE A N   1 
ATOM 2192  C CA  . ILE A 1 296 ? 12.964  -4.892  7.664   1.00 63.56  ? 290 ILE A CA  1 
ATOM 2193  C C   . ILE A 1 296 ? 14.489  -4.821  7.627   1.00 61.37  ? 290 ILE A C   1 
ATOM 2194  O O   . ILE A 1 296 ? 15.108  -4.983  8.678   1.00 67.96  ? 290 ILE A O   1 
ATOM 2195  C CB  . ILE A 1 296 ? 12.398  -6.311  7.468   1.00 70.71  ? 290 ILE A CB  1 
ATOM 2196  C CG1 . ILE A 1 296 ? 12.963  -7.010  6.239   1.00 76.40  ? 290 ILE A CG1 1 
ATOM 2197  C CG2 . ILE A 1 296 ? 10.870  -6.287  7.448   1.00 70.37  ? 290 ILE A CG2 1 
ATOM 2198  C CD1 . ILE A 1 296 ? 12.769  -8.514  6.243   1.00 73.57  ? 290 ILE A CD1 1 
ATOM 2199  N N   . ALA A 1 297 ? 15.066  -4.714  6.446   1.00 59.31  ? 291 ALA A N   1 
ATOM 2200  C CA  . ALA A 1 297 ? 16.535  -4.717  6.343   1.00 55.01  ? 291 ALA A CA  1 
ATOM 2201  C C   . ALA A 1 297 ? 17.136  -3.413  6.859   1.00 53.06  ? 291 ALA A C   1 
ATOM 2202  O O   . ALA A 1 297 ? 18.309  -3.434  7.240   1.00 46.51  ? 291 ALA A O   1 
ATOM 2203  C CB  . ALA A 1 297 ? 16.895  -4.944  4.917   1.00 54.25  ? 291 ALA A CB  1 
ATOM 2204  N N   . GLU A 1 298 ? 16.371  -2.319  6.838   1.00 64.82  ? 292 GLU A N   1 
ATOM 2205  C CA  . GLU A 1 298 ? 16.882  -1.025  7.348   1.00 74.53  ? 292 GLU A CA  1 
ATOM 2206  C C   . GLU A 1 298 ? 16.405  -0.820  8.783   1.00 66.57  ? 292 GLU A C   1 
ATOM 2207  O O   . GLU A 1 298 ? 16.820  0.163   9.403   1.00 66.23  ? 292 GLU A O   1 
ATOM 2208  C CB  . GLU A 1 298 ? 16.312  0.059   6.438   1.00 84.23  ? 292 GLU A CB  1 
ATOM 2209  C CG  . GLU A 1 298 ? 17.189  0.394   5.238   1.00 89.82  ? 292 GLU A CG  1 
ATOM 2210  C CD  . GLU A 1 298 ? 16.586  1.547   4.459   1.00 100.98 ? 292 GLU A CD  1 
ATOM 2211  O OE1 . GLU A 1 298 ? 15.350  1.700   4.527   1.00 104.82 ? 292 GLU A OE1 1 
ATOM 2212  O OE2 . GLU A 1 298 ? 17.340  2.291   3.797   1.00 109.33 ? 292 GLU A OE2 1 
ATOM 2213  N N   . VAL A 1 299 ? 15.617  -1.743  9.306   1.00 69.85  ? 293 VAL A N   1 
ATOM 2214  C CA  . VAL A 1 299 ? 14.953  -1.541  10.627  1.00 69.67  ? 293 VAL A CA  1 
ATOM 2215  C C   . VAL A 1 299 ? 15.983  -1.429  11.755  1.00 68.13  ? 293 VAL A C   1 
ATOM 2216  O O   . VAL A 1 299 ? 17.049  -2.051  11.668  1.00 56.04  ? 293 VAL A O   1 
ATOM 2217  C CB  . VAL A 1 299 ? 13.863  -2.584  10.953  1.00 63.63  ? 293 VAL A CB  1 
ATOM 2218  C CG1 . VAL A 1 299 ? 14.443  -3.851  11.562  1.00 63.38  ? 293 VAL A CG1 1 
ATOM 2219  C CG2 . VAL A 1 299 ? 12.781  -2.006  11.850  1.00 64.74  ? 293 VAL A CG2 1 
ATOM 2220  N N   . GLU A 1 300 ? 15.672  -0.577  12.723  1.00 72.59  ? 294 GLU A N   1 
ATOM 2221  C CA  . GLU A 1 300 ? 16.574  -0.270  13.850  1.00 72.10  ? 294 GLU A CA  1 
ATOM 2222  C C   . GLU A 1 300 ? 16.771  -1.450  14.794  1.00 67.16  ? 294 GLU A C   1 
ATOM 2223  O O   . GLU A 1 300 ? 15.859  -2.272  14.944  1.00 56.53  ? 294 GLU A O   1 
ATOM 2224  C CB  . GLU A 1 300 ? 16.035  0.944   14.606  1.00 77.70  ? 294 GLU A CB  1 
ATOM 2225  C CG  . GLU A 1 300 ? 14.516  1.075   14.566  1.00 91.89  ? 294 GLU A CG  1 
ATOM 2226  C CD  . GLU A 1 300 ? 13.958  2.003   15.630  1.00 100.94 ? 294 GLU A CD  1 
ATOM 2227  O OE1 . GLU A 1 300 ? 14.728  2.412   16.525  1.00 92.80  ? 294 GLU A OE1 1 
ATOM 2228  O OE2 . GLU A 1 300 ? 12.751  2.316   15.564  1.00 97.69  ? 294 GLU A OE2 1 
ATOM 2229  N N   . ASN A 1 301 ? 17.953  -1.505  15.388  1.00 69.27  ? 295 ASN A N   1 
ATOM 2230  C CA  . ASN A 1 301 ? 18.314  -2.577  16.338  1.00 61.08  ? 295 ASN A CA  1 
ATOM 2231  C C   . ASN A 1 301 ? 17.397  -2.462  17.548  1.00 57.00  ? 295 ASN A C   1 
ATOM 2232  O O   . ASN A 1 301 ? 16.994  -1.343  17.872  1.00 58.70  ? 295 ASN A O   1 
ATOM 2233  C CB  . ASN A 1 301 ? 19.784  -2.438  16.724  1.00 56.95  ? 295 ASN A CB  1 
ATOM 2234  C CG  . ASN A 1 301 ? 20.717  -2.503  15.544  1.00 51.81  ? 295 ASN A CG  1 
ATOM 2235  O OD1 . ASN A 1 301 ? 20.271  -2.640  14.402  1.00 41.83  ? 295 ASN A OD1 1 
ATOM 2236  N ND2 . ASN A 1 301 ? 22.011  -2.410  15.804  1.00 50.59  ? 295 ASN A ND2 1 
ATOM 2237  N N   . ASP A 1 302 ? 17.005  -3.597  18.117  1.00 56.34  ? 296 ASP A N   1 
ATOM 2238  C CA  . ASP A 1 302 ? 16.114  -3.600  19.306  1.00 60.72  ? 296 ASP A CA  1 
ATOM 2239  C C   . ASP A 1 302 ? 16.903  -3.311  20.582  1.00 57.89  ? 296 ASP A C   1 
ATOM 2240  O O   . ASP A 1 302 ? 18.139  -3.312  20.546  1.00 51.83  ? 296 ASP A O   1 
ATOM 2241  C CB  . ASP A 1 302 ? 15.312  -4.888  19.417  1.00 65.17  ? 296 ASP A CB  1 
ATOM 2242  C CG  . ASP A 1 302 ? 13.889  -4.756  19.933  1.00 65.56  ? 296 ASP A CG  1 
ATOM 2243  O OD1 . ASP A 1 302 ? 13.548  -3.677  20.442  1.00 59.51  ? 296 ASP A OD1 1 
ATOM 2244  O OD2 . ASP A 1 302 ? 13.138  -5.740  19.823  1.00 67.91  ? 296 ASP A OD2 1 
ATOM 2245  N N   . GLU A 1 303 ? 16.184  -3.045  21.661  1.00 61.06  ? 297 GLU A N   1 
ATOM 2246  C CA  . GLU A 1 303 ? 16.786  -2.752  22.949  1.00 64.43  ? 297 GLU A CA  1 
ATOM 2247  C C   . GLU A 1 303 ? 17.388  -4.054  23.457  1.00 67.04  ? 297 GLU A C   1 
ATOM 2248  O O   . GLU A 1 303 ? 16.691  -5.066  23.521  1.00 72.94  ? 297 GLU A O   1 
ATOM 2249  C CB  . GLU A 1 303 ? 15.754  -2.220  23.947  1.00 74.12  ? 297 GLU A CB  1 
ATOM 2250  C CG  . GLU A 1 303 ? 15.303  -0.779  23.699  1.00 85.61  ? 297 GLU A CG  1 
ATOM 2251  C CD  . GLU A 1 303 ? 14.287  -0.520  22.585  1.00 90.34  ? 297 GLU A CD  1 
ATOM 2252  O OE1 . GLU A 1 303 ? 13.575  -1.449  22.132  1.00 85.87  ? 297 GLU A OE1 1 
ATOM 2253  O OE2 . GLU A 1 303 ? 14.224  0.650   22.143  1.00 86.74  ? 297 GLU A OE2 1 
ATOM 2254  N N   . MET A 1 304 ? 18.681  -4.040  23.784  1.00 63.52  ? 298 MET A N   1 
ATOM 2255  C CA  . MET A 1 304 ? 19.346  -5.290  24.091  1.00 67.24  ? 298 MET A CA  1 
ATOM 2256  C C   . MET A 1 304 ? 18.837  -5.759  25.448  1.00 67.22  ? 298 MET A C   1 
ATOM 2257  O O   . MET A 1 304 ? 18.526  -4.946  26.305  1.00 73.69  ? 298 MET A O   1 
ATOM 2258  C CB  . MET A 1 304 ? 20.873  -5.172  24.009  1.00 71.89  ? 298 MET A CB  1 
ATOM 2259  C CG  . MET A 1 304 ? 21.523  -4.330  25.084  1.00 78.67  ? 298 MET A CG  1 
ATOM 2260  S SD  . MET A 1 304 ? 23.243  -4.803  25.366  1.00 86.03  ? 298 MET A SD  1 
ATOM 2261  C CE  . MET A 1 304 ? 22.957  -6.378  26.190  1.00 82.97  ? 298 MET A CE  1 
ATOM 2262  N N   . PRO A 1 305 ? 18.684  -7.081  25.659  1.00 74.13  ? 299 PRO A N   1 
ATOM 2263  C CA  . PRO A 1 305 ? 18.021  -7.589  26.860  1.00 80.31  ? 299 PRO A CA  1 
ATOM 2264  C C   . PRO A 1 305 ? 18.807  -7.473  28.166  1.00 75.85  ? 299 PRO A C   1 
ATOM 2265  O O   . PRO A 1 305 ? 20.042  -7.360  28.171  1.00 61.33  ? 299 PRO A O   1 
ATOM 2266  C CB  . PRO A 1 305 ? 17.738  -9.065  26.495  1.00 83.41  ? 299 PRO A CB  1 
ATOM 2267  C CG  . PRO A 1 305 ? 18.830  -9.427  25.508  1.00 80.68  ? 299 PRO A CG  1 
ATOM 2268  C CD  . PRO A 1 305 ? 19.116  -8.146  24.741  1.00 76.81  ? 299 PRO A CD  1 
ATOM 2269  N N   . ALA A 1 306 ? 18.032  -7.531  29.260  1.00 73.26  ? 300 ALA A N   1 
ATOM 2270  C CA  . ALA A 1 306 ? 18.553  -7.546  30.613  1.00 75.15  ? 300 ALA A CA  1 
ATOM 2271  C C   . ALA A 1 306 ? 18.627  -8.984  31.120  1.00 75.53  ? 300 ALA A C   1 
ATOM 2272  O O   . ALA A 1 306 ? 17.858  -9.853  30.711  1.00 68.03  ? 300 ALA A O   1 
ATOM 2273  C CB  . ALA A 1 306 ? 17.674  -6.703  31.505  1.00 79.55  ? 300 ALA A CB  1 
ATOM 2274  N N   . ASP A 1 307 ? 19.546  -9.187  32.065  1.00 83.55  ? 301 ASP A N   1 
ATOM 2275  C CA  . ASP A 1 307 ? 19.834  -10.486 32.655  1.00 85.52  ? 301 ASP A CA  1 
ATOM 2276  C C   . ASP A 1 307 ? 20.415  -11.410 31.587  1.00 71.04  ? 301 ASP A C   1 
ATOM 2277  O O   . ASP A 1 307 ? 19.846  -12.440 31.248  1.00 61.57  ? 301 ASP A O   1 
ATOM 2278  C CB  . ASP A 1 307 ? 18.675  -10.995 33.500  1.00 95.14  ? 301 ASP A CB  1 
ATOM 2279  C CG  . ASP A 1 307 ? 18.642  -10.479 34.938  1.00 110.57 ? 301 ASP A CG  1 
ATOM 2280  O OD1 . ASP A 1 307 ? 19.667  -10.628 35.655  1.00 111.58 ? 301 ASP A OD1 1 
ATOM 2281  O OD2 . ASP A 1 307 ? 17.590  -9.940  35.342  1.00 117.54 ? 301 ASP A OD2 1 
ATOM 2282  N N   . LEU A 1 308 ? 21.558  -10.973 31.052  1.00 65.79  ? 302 LEU A N   1 
ATOM 2283  C CA  . LEU A 1 308 ? 22.494  -11.804 30.317  1.00 59.41  ? 302 LEU A CA  1 
ATOM 2284  C C   . LEU A 1 308 ? 23.690  -12.055 31.225  1.00 47.96  ? 302 LEU A C   1 
ATOM 2285  O O   . LEU A 1 308 ? 24.185  -11.115 31.829  1.00 43.50  ? 302 LEU A O   1 
ATOM 2286  C CB  . LEU A 1 308 ? 22.957  -11.059 29.064  1.00 65.34  ? 302 LEU A CB  1 
ATOM 2287  C CG  . LEU A 1 308 ? 21.932  -10.836 27.951  1.00 71.51  ? 302 LEU A CG  1 
ATOM 2288  C CD1 . LEU A 1 308 ? 22.593  -10.183 26.756  1.00 71.81  ? 302 LEU A CD1 1 
ATOM 2289  C CD2 . LEU A 1 308 ? 21.319  -12.158 27.548  1.00 83.39  ? 302 LEU A CD2 1 
ATOM 2290  N N   . PRO A 1 309 ? 24.233  -13.285 31.212  1.00 46.75  ? 303 PRO A N   1 
ATOM 2291  C CA  . PRO A 1 309 ? 25.427  -13.558 31.964  1.00 50.46  ? 303 PRO A CA  1 
ATOM 2292  C C   . PRO A 1 309 ? 26.591  -12.943 31.228  1.00 46.12  ? 303 PRO A C   1 
ATOM 2293  O O   . PRO A 1 309 ? 26.437  -12.435 30.121  1.00 49.53  ? 303 PRO A O   1 
ATOM 2294  C CB  . PRO A 1 309 ? 25.430  -15.084 31.930  1.00 51.54  ? 303 PRO A CB  1 
ATOM 2295  C CG  . PRO A 1 309 ? 24.038  -15.482 31.562  1.00 50.74  ? 303 PRO A CG  1 
ATOM 2296  C CD  . PRO A 1 309 ? 23.752  -14.465 30.501  1.00 51.17  ? 303 PRO A CD  1 
ATOM 2297  N N   . SER A 1 310 ? 27.758  -12.998 31.831  1.00 45.44  ? 304 SER A N   1 
ATOM 2298  C CA  . SER A 1 310 ? 28.981  -12.504 31.176  1.00 52.32  ? 304 SER A CA  1 
ATOM 2299  C C   . SER A 1 310 ? 29.340  -13.425 30.012  1.00 56.49  ? 304 SER A C   1 
ATOM 2300  O O   . SER A 1 310 ? 29.014  -14.614 30.080  1.00 58.22  ? 304 SER A O   1 
ATOM 2301  C CB  . SER A 1 310 ? 30.111  -12.410 32.135  1.00 56.32  ? 304 SER A CB  1 
ATOM 2302  O OG  . SER A 1 310 ? 31.349  -12.368 31.442  1.00 61.41  ? 304 SER A OG  1 
ATOM 2303  N N   . LEU A 1 311 ? 29.997  -12.888 28.999  1.00 60.55  ? 305 LEU A N   1 
ATOM 2304  C CA  . LEU A 1 311 ? 30.367  -13.653 27.785  1.00 67.95  ? 305 LEU A CA  1 
ATOM 2305  C C   . LEU A 1 311 ? 31.296  -14.764 28.243  1.00 69.91  ? 305 LEU A C   1 
ATOM 2306  O O   . LEU A 1 311 ? 31.188  -15.874 27.712  1.00 81.38  ? 305 LEU A O   1 
ATOM 2307  C CB  . LEU A 1 311 ? 31.041  -12.748 26.760  1.00 71.05  ? 305 LEU A CB  1 
ATOM 2308  C CG  . LEU A 1 311 ? 30.473  -12.784 25.341  1.00 74.80  ? 305 LEU A CG  1 
ATOM 2309  C CD1 . LEU A 1 311 ? 31.456  -13.471 24.422  1.00 78.60  ? 305 LEU A CD1 1 
ATOM 2310  C CD2 . LEU A 1 311 ? 29.159  -13.525 25.353  1.00 80.83  ? 305 LEU A CD2 1 
ATOM 2311  N N   . ALA A 1 312 ? 32.156  -14.479 29.197  1.00 65.75  ? 306 ALA A N   1 
ATOM 2312  C CA  . ALA A 1 312 ? 33.203  -15.419 29.638  1.00 68.36  ? 306 ALA A CA  1 
ATOM 2313  C C   . ALA A 1 312 ? 32.615  -16.703 30.199  1.00 68.65  ? 306 ALA A C   1 
ATOM 2314  O O   . ALA A 1 312 ? 33.204  -17.770 29.971  1.00 60.34  ? 306 ALA A O   1 
ATOM 2315  C CB  . ALA A 1 312 ? 34.030  -14.731 30.678  1.00 72.77  ? 306 ALA A CB  1 
ATOM 2316  N N   . ALA A 1 313 ? 31.510  -16.639 30.918  1.00 68.77  ? 307 ALA A N   1 
ATOM 2317  C CA  . ALA A 1 313 ? 31.060  -17.822 31.676  1.00 70.11  ? 307 ALA A CA  1 
ATOM 2318  C C   . ALA A 1 313 ? 30.750  -19.047 30.828  1.00 71.68  ? 307 ALA A C   1 
ATOM 2319  O O   . ALA A 1 313 ? 31.136  -20.132 31.273  1.00 76.71  ? 307 ALA A O   1 
ATOM 2320  C CB  . ALA A 1 313 ? 29.788  -17.403 32.340  1.00 67.65  ? 307 ALA A CB  1 
ATOM 2321  N N   . ASP A 1 314 ? 30.127  -18.902 29.683  1.00 71.02  ? 308 ASP A N   1 
ATOM 2322  C CA  . ASP A 1 314 ? 29.995  -20.113 28.843  1.00 69.79  ? 308 ASP A CA  1 
ATOM 2323  C C   . ASP A 1 314 ? 31.333  -20.276 28.108  1.00 63.44  ? 308 ASP A C   1 
ATOM 2324  O O   . ASP A 1 314 ? 31.981  -21.295 28.310  1.00 70.33  ? 308 ASP A O   1 
ATOM 2325  C CB  . ASP A 1 314 ? 28.726  -20.065 28.012  1.00 76.00  ? 308 ASP A CB  1 
ATOM 2326  C CG  . ASP A 1 314 ? 27.436  -20.399 28.746  1.00 76.91  ? 308 ASP A CG  1 
ATOM 2327  O OD1 . ASP A 1 314 ? 27.510  -20.762 29.934  1.00 70.23  ? 308 ASP A OD1 1 
ATOM 2328  O OD2 . ASP A 1 314 ? 26.366  -20.293 28.121  1.00 74.95  ? 308 ASP A OD2 1 
ATOM 2329  N N   . PHE A 1 315 ? 31.675  -19.364 27.212  1.00 56.05  ? 309 PHE A N   1 
ATOM 2330  C CA  . PHE A 1 315 ? 32.923  -19.460 26.414  1.00 53.85  ? 309 PHE A CA  1 
ATOM 2331  C C   . PHE A 1 315 ? 34.325  -19.400 27.113  1.00 53.90  ? 309 PHE A C   1 
ATOM 2332  O O   . PHE A 1 315 ? 35.183  -20.117 26.598  1.00 46.03  ? 309 PHE A O   1 
ATOM 2333  C CB  . PHE A 1 315 ? 32.567  -18.332 25.446  1.00 52.74  ? 309 PHE A CB  1 
ATOM 2334  C CG  . PHE A 1 315 ? 31.202  -18.541 24.815  1.00 50.45  ? 309 PHE A CG  1 
ATOM 2335  C CD1 . PHE A 1 315 ? 30.980  -19.601 23.950  1.00 51.18  ? 309 PHE A CD1 1 
ATOM 2336  C CD2 . PHE A 1 315 ? 30.142  -17.697 25.111  1.00 54.75  ? 309 PHE A CD2 1 
ATOM 2337  C CE1 . PHE A 1 315 ? 29.735  -19.801 23.387  1.00 60.33  ? 309 PHE A CE1 1 
ATOM 2338  C CE2 . PHE A 1 315 ? 28.898  -17.903 24.546  1.00 61.68  ? 309 PHE A CE2 1 
ATOM 2339  C CZ  . PHE A 1 315 ? 28.698  -18.953 23.685  1.00 64.09  ? 309 PHE A CZ  1 
ATOM 2340  N N   . VAL A 1 316 ? 34.630  -18.545 28.093  1.00 57.03  ? 310 VAL A N   1 
ATOM 2341  C CA  . VAL A 1 316 ? 36.015  -18.592 28.690  1.00 59.69  ? 310 VAL A CA  1 
ATOM 2342  C C   . VAL A 1 316 ? 36.143  -19.302 30.049  1.00 67.66  ? 310 VAL A C   1 
ATOM 2343  O O   . VAL A 1 316 ? 37.122  -20.034 30.241  1.00 61.72  ? 310 VAL A O   1 
ATOM 2344  C CB  . VAL A 1 316 ? 36.581  -17.167 28.816  1.00 57.23  ? 310 VAL A CB  1 
ATOM 2345  C CG1 . VAL A 1 316 ? 38.046  -17.161 29.222  1.00 53.10  ? 310 VAL A CG1 1 
ATOM 2346  C CG2 . VAL A 1 316 ? 36.364  -16.374 27.539  1.00 59.98  ? 310 VAL A CG2 1 
ATOM 2347  N N   . GLU A 1 317 ? 35.254  -18.996 30.988  1.00 81.23  ? 311 GLU A N   1 
ATOM 2348  C CA  . GLU A 1 317 ? 35.276  -19.583 32.358  1.00 86.96  ? 311 GLU A CA  1 
ATOM 2349  C C   . GLU A 1 317 ? 35.031  -21.099 32.427  1.00 79.86  ? 311 GLU A C   1 
ATOM 2350  O O   . GLU A 1 317 ? 35.695  -21.748 33.245  1.00 88.75  ? 311 GLU A O   1 
ATOM 2351  C CB  . GLU A 1 317 ? 34.292  -18.787 33.209  1.00 102.01 ? 311 GLU A CB  1 
ATOM 2352  C CG  . GLU A 1 317 ? 34.642  -17.305 33.283  1.00 107.12 ? 311 GLU A CG  1 
ATOM 2353  C CD  . GLU A 1 317 ? 35.880  -17.064 34.121  1.00 117.18 ? 311 GLU A CD  1 
ATOM 2354  O OE1 . GLU A 1 317 ? 35.872  -17.487 35.296  1.00 135.36 ? 311 GLU A OE1 1 
ATOM 2355  O OE2 . GLU A 1 317 ? 36.846  -16.465 33.605  1.00 111.22 ? 311 GLU A OE2 1 
ATOM 2356  N N   . SER A 1 318 ? 34.098  -21.630 31.637  1.00 70.30  ? 312 SER A N   1 
ATOM 2357  C CA  . SER A 1 318 ? 33.690  -23.052 31.771  1.00 67.79  ? 312 SER A CA  1 
ATOM 2358  C C   . SER A 1 318 ? 34.868  -24.009 31.659  1.00 71.97  ? 312 SER A C   1 
ATOM 2359  O O   . SER A 1 318 ? 35.832  -23.690 30.950  1.00 75.93  ? 312 SER A O   1 
ATOM 2360  C CB  . SER A 1 318 ? 32.644  -23.415 30.770  1.00 66.17  ? 312 SER A CB  1 
ATOM 2361  O OG  . SER A 1 318 ? 31.848  -24.496 31.233  1.00 62.89  ? 312 SER A OG  1 
ATOM 2362  N N   . LYS A 1 319 ? 34.788  -25.134 32.365  1.00 71.91  ? 313 LYS A N   1 
ATOM 2363  C CA  . LYS A 1 319 ? 35.833  -26.129 32.166  1.00 72.83  ? 313 LYS A CA  1 
ATOM 2364  C C   . LYS A 1 319 ? 35.327  -27.179 31.179  1.00 74.90  ? 313 LYS A C   1 
ATOM 2365  O O   . LYS A 1 319 ? 35.809  -28.309 31.168  1.00 82.86  ? 313 LYS A O   1 
ATOM 2366  C CB  . LYS A 1 319 ? 36.280  -26.737 33.501  1.00 76.76  ? 313 LYS A CB  1 
ATOM 2367  C CG  . LYS A 1 319 ? 37.019  -25.779 34.437  1.00 83.95  ? 313 LYS A CG  1 
ATOM 2368  C CD  . LYS A 1 319 ? 37.630  -26.421 35.680  1.00 86.42  ? 313 LYS A CD  1 
ATOM 2369  C CE  . LYS A 1 319 ? 38.799  -27.318 35.390  1.00 88.37  ? 313 LYS A CE  1 
ATOM 2370  N NZ  . LYS A 1 319 ? 39.933  -26.571 34.843  1.00 86.38  ? 313 LYS A NZ  1 
ATOM 2371  N N   . ASP A 1 320 ? 34.357  -26.775 30.345  1.00 76.80  ? 314 ASP A N   1 
ATOM 2372  C CA  . ASP A 1 320 ? 33.662  -27.663 29.427  1.00 75.61  ? 314 ASP A CA  1 
ATOM 2373  C C   . ASP A 1 320 ? 33.774  -27.162 27.988  1.00 70.06  ? 314 ASP A C   1 
ATOM 2374  O O   . ASP A 1 320 ? 33.166  -27.734 27.085  1.00 73.19  ? 314 ASP A O   1 
ATOM 2375  C CB  . ASP A 1 320 ? 32.189  -27.779 29.792  1.00 74.70  ? 314 ASP A CB  1 
ATOM 2376  C CG  . ASP A 1 320 ? 31.890  -28.495 31.100  1.00 72.78  ? 314 ASP A CG  1 
ATOM 2377  O OD1 . ASP A 1 320 ? 32.831  -29.110 31.657  1.00 67.50  ? 314 ASP A OD1 1 
ATOM 2378  O OD2 . ASP A 1 320 ? 30.716  -28.439 31.537  1.00 74.29  ? 314 ASP A OD2 1 
ATOM 2379  N N   . VAL A 1 321 ? 34.568  -26.115 27.763  1.00 64.54  ? 315 VAL A N   1 
ATOM 2380  C CA  . VAL A 1 321 ? 34.627  -25.505 26.448  1.00 64.81  ? 315 VAL A CA  1 
ATOM 2381  C C   . VAL A 1 321 ? 34.990  -26.588 25.426  1.00 60.27  ? 315 VAL A C   1 
ATOM 2382  O O   . VAL A 1 321 ? 34.266  -26.807 24.459  1.00 61.03  ? 315 VAL A O   1 
ATOM 2383  C CB  . VAL A 1 321 ? 35.595  -24.303 26.406  1.00 65.12  ? 315 VAL A CB  1 
ATOM 2384  C CG1 . VAL A 1 321 ? 35.607  -23.631 25.038  1.00 69.67  ? 315 VAL A CG1 1 
ATOM 2385  C CG2 . VAL A 1 321 ? 35.256  -23.264 27.465  1.00 60.81  ? 315 VAL A CG2 1 
ATOM 2386  N N   . CYS A 1 322 ? 36.167  -27.148 25.624  1.00 53.44  ? 316 CYS A N   1 
ATOM 2387  C CA  . CYS A 1 322 ? 36.674  -28.103 24.625  1.00 55.29  ? 316 CYS A CA  1 
ATOM 2388  C C   . CYS A 1 322 ? 35.573  -29.134 24.382  1.00 57.94  ? 316 CYS A C   1 
ATOM 2389  O O   . CYS A 1 322 ? 35.294  -29.423 23.215  1.00 62.63  ? 316 CYS A O   1 
ATOM 2390  C CB  . CYS A 1 322 ? 38.033  -28.594 25.098  1.00 58.54  ? 316 CYS A CB  1 
ATOM 2391  S SG  . CYS A 1 322 ? 39.357  -27.381 24.863  1.00 65.16  ? 316 CYS A SG  1 
ATOM 2392  N N   . LYS A 1 323 ? 35.020  -29.711 25.434  1.00 62.32  ? 317 LYS A N   1 
ATOM 2393  C CA  . LYS A 1 323 ? 34.008  -30.754 25.178  1.00 65.67  ? 317 LYS A CA  1 
ATOM 2394  C C   . LYS A 1 323 ? 32.806  -30.149 24.461  1.00 63.18  ? 317 LYS A C   1 
ATOM 2395  O O   . LYS A 1 323 ? 32.283  -30.789 23.540  1.00 72.33  ? 317 LYS A O   1 
ATOM 2396  C CB  . LYS A 1 323 ? 33.547  -31.324 26.519  1.00 70.20  ? 317 LYS A CB  1 
ATOM 2397  C CG  . LYS A 1 323 ? 32.098  -31.767 26.600  1.00 75.89  ? 317 LYS A CG  1 
ATOM 2398  C CD  . LYS A 1 323 ? 31.593  -31.940 28.026  1.00 81.40  ? 317 LYS A CD  1 
ATOM 2399  C CE  . LYS A 1 323 ? 30.107  -32.100 28.088  1.00 84.48  ? 317 LYS A CE  1 
ATOM 2400  N NZ  . LYS A 1 323 ? 29.483  -31.947 26.772  1.00 86.03  ? 317 LYS A NZ  1 
ATOM 2401  N N   . ASN A 1 324 ? 32.381  -28.969 24.890  1.00 54.95  ? 318 ASN A N   1 
ATOM 2402  C CA  . ASN A 1 324 ? 31.232  -28.294 24.236  1.00 57.97  ? 318 ASN A CA  1 
ATOM 2403  C C   . ASN A 1 324 ? 31.556  -27.933 22.782  1.00 64.18  ? 318 ASN A C   1 
ATOM 2404  O O   . ASN A 1 324 ? 30.674  -28.101 21.914  1.00 58.87  ? 318 ASN A O   1 
ATOM 2405  C CB  . ASN A 1 324 ? 30.761  -27.140 25.106  1.00 58.59  ? 318 ASN A CB  1 
ATOM 2406  C CG  . ASN A 1 324 ? 30.025  -27.608 26.334  1.00 59.00  ? 318 ASN A CG  1 
ATOM 2407  O OD1 . ASN A 1 324 ? 30.296  -27.131 27.438  1.00 55.31  ? 318 ASN A OD1 1 
ATOM 2408  N ND2 . ASN A 1 324 ? 29.087  -28.526 26.161  1.00 64.42  ? 318 ASN A ND2 1 
ATOM 2409  N N   . TYR A 1 325 ? 32.770  -27.440 22.530  1.00 69.65  ? 319 TYR A N   1 
ATOM 2410  C CA  . TYR A 1 325 ? 33.196  -27.055 21.157  1.00 68.13  ? 319 TYR A CA  1 
ATOM 2411  C C   . TYR A 1 325 ? 33.213  -28.258 20.296  1.00 68.97  ? 319 TYR A C   1 
ATOM 2412  O O   . TYR A 1 325 ? 32.844  -28.209 19.121  1.00 68.29  ? 319 TYR A O   1 
ATOM 2413  C CB  . TYR A 1 325 ? 34.602  -26.471 21.227  1.00 67.73  ? 319 TYR A CB  1 
ATOM 2414  C CG  . TYR A 1 325 ? 35.228  -26.020 19.916  1.00 62.87  ? 319 TYR A CG  1 
ATOM 2415  C CD1 . TYR A 1 325 ? 34.503  -25.299 18.979  1.00 54.11  ? 319 TYR A CD1 1 
ATOM 2416  C CD2 . TYR A 1 325 ? 36.558  -26.302 19.635  1.00 59.19  ? 319 TYR A CD2 1 
ATOM 2417  C CE1 . TYR A 1 325 ? 35.080  -24.881 17.793  1.00 55.05  ? 319 TYR A CE1 1 
ATOM 2418  C CE2 . TYR A 1 325 ? 37.145  -25.892 18.453  1.00 58.30  ? 319 TYR A CE2 1 
ATOM 2419  C CZ  . TYR A 1 325 ? 36.403  -25.182 17.530  1.00 63.30  ? 319 TYR A CZ  1 
ATOM 2420  O OH  . TYR A 1 325 ? 36.987  -24.781 16.368  1.00 74.93  ? 319 TYR A OH  1 
ATOM 2421  N N   . ALA A 1 326 ? 33.695  -29.340 20.873  1.00 64.08  ? 320 ALA A N   1 
ATOM 2422  C CA  . ALA A 1 326 ? 33.791  -30.605 20.133  1.00 63.10  ? 320 ALA A CA  1 
ATOM 2423  C C   . ALA A 1 326 ? 32.434  -31.151 19.703  1.00 62.56  ? 320 ALA A C   1 
ATOM 2424  O O   . ALA A 1 326 ? 32.369  -31.721 18.608  1.00 68.98  ? 320 ALA A O   1 
ATOM 2425  C CB  . ALA A 1 326 ? 34.541  -31.582 20.973  1.00 64.10  ? 320 ALA A CB  1 
ATOM 2426  N N   . GLU A 1 327 ? 31.399  -31.072 20.540  1.00 60.84  ? 321 GLU A N   1 
ATOM 2427  C CA  . GLU A 1 327 ? 30.179  -31.768 20.073  1.00 68.04  ? 321 GLU A CA  1 
ATOM 2428  C C   . GLU A 1 327 ? 29.683  -31.135 18.787  1.00 61.43  ? 321 GLU A C   1 
ATOM 2429  O O   . GLU A 1 327 ? 29.325  -31.917 17.892  1.00 63.77  ? 321 GLU A O   1 
ATOM 2430  C CB  . GLU A 1 327 ? 29.144  -31.685 21.190  1.00 83.97  ? 321 GLU A CB  1 
ATOM 2431  C CG  . GLU A 1 327 ? 27.709  -31.489 20.716  1.00 94.93  ? 321 GLU A CG  1 
ATOM 2432  C CD  . GLU A 1 327 ? 26.835  -30.939 21.828  1.00 114.78 ? 321 GLU A CD  1 
ATOM 2433  O OE1 . GLU A 1 327 ? 27.360  -30.760 22.948  1.00 121.92 ? 321 GLU A OE1 1 
ATOM 2434  O OE2 . GLU A 1 327 ? 25.638  -30.689 21.576  1.00 126.01 ? 321 GLU A OE2 1 
ATOM 2435  N N   . ALA A 1 328 ? 29.619  -29.811 18.663  1.00 55.78  ? 322 ALA A N   1 
ATOM 2436  C CA  . ALA A 1 328 ? 29.472  -29.204 17.326  1.00 55.90  ? 322 ALA A CA  1 
ATOM 2437  C C   . ALA A 1 328 ? 30.485  -28.082 17.294  1.00 54.00  ? 322 ALA A C   1 
ATOM 2438  O O   . ALA A 1 328 ? 30.238  -27.115 18.007  1.00 54.29  ? 322 ALA A O   1 
ATOM 2439  C CB  . ALA A 1 328 ? 28.083  -28.688 17.176  1.00 55.23  ? 322 ALA A CB  1 
ATOM 2440  N N   . LYS A 1 329 ? 31.491  -28.106 16.444  1.00 53.38  ? 323 LYS A N   1 
ATOM 2441  C CA  . LYS A 1 329 ? 32.334  -26.893 16.461  1.00 59.64  ? 323 LYS A CA  1 
ATOM 2442  C C   . LYS A 1 329 ? 31.560  -25.661 15.964  1.00 64.76  ? 323 LYS A C   1 
ATOM 2443  O O   . LYS A 1 329 ? 31.649  -24.594 16.589  1.00 58.39  ? 323 LYS A O   1 
ATOM 2444  C CB  . LYS A 1 329 ? 33.605  -27.218 15.673  1.00 59.51  ? 323 LYS A CB  1 
ATOM 2445  C CG  . LYS A 1 329 ? 34.528  -28.254 16.286  1.00 57.54  ? 323 LYS A CG  1 
ATOM 2446  C CD  . LYS A 1 329 ? 35.900  -28.240 15.627  1.00 55.86  ? 323 LYS A CD  1 
ATOM 2447  C CE  . LYS A 1 329 ? 36.838  -29.244 16.203  1.00 59.13  ? 323 LYS A CE  1 
ATOM 2448  N NZ  . LYS A 1 329 ? 38.082  -29.309 15.434  1.00 61.81  ? 323 LYS A NZ  1 
ATOM 2449  N N   . ASP A 1 330 ? 30.810  -25.833 14.876  1.00 70.95  ? 324 ASP A N   1 
ATOM 2450  C CA  . ASP A 1 330 ? 30.133  -24.670 14.226  1.00 68.49  ? 324 ASP A CA  1 
ATOM 2451  C C   . ASP A 1 330 ? 29.041  -23.977 15.039  1.00 64.27  ? 324 ASP A C   1 
ATOM 2452  O O   . ASP A 1 330 ? 29.001  -22.742 15.017  1.00 74.26  ? 324 ASP A O   1 
ATOM 2453  C CB  . ASP A 1 330 ? 29.696  -25.023 12.812  1.00 65.29  ? 324 ASP A CB  1 
ATOM 2454  C CG  . ASP A 1 330 ? 30.802  -24.957 11.772  1.00 66.06  ? 324 ASP A CG  1 
ATOM 2455  O OD1 . ASP A 1 330 ? 31.975  -24.824 12.175  1.00 57.56  ? 324 ASP A OD1 1 
ATOM 2456  O OD2 . ASP A 1 330 ? 30.481  -25.038 10.573  1.00 71.50  ? 324 ASP A OD2 1 
ATOM 2457  N N   . VAL A 1 331 ? 28.184  -24.743 15.703  1.00 57.29  ? 325 VAL A N   1 
ATOM 2458  C CA  . VAL A 1 331 ? 27.140  -24.115 16.563  1.00 53.12  ? 325 VAL A CA  1 
ATOM 2459  C C   . VAL A 1 331 ? 27.843  -23.377 17.700  1.00 46.67  ? 325 VAL A C   1 
ATOM 2460  O O   . VAL A 1 331 ? 27.367  -22.303 18.082  1.00 40.01  ? 325 VAL A O   1 
ATOM 2461  C CB  . VAL A 1 331 ? 26.023  -25.046 17.058  1.00 54.38  ? 325 VAL A CB  1 
ATOM 2462  C CG1 . VAL A 1 331 ? 25.031  -24.317 17.952  1.00 51.38  ? 325 VAL A CG1 1 
ATOM 2463  C CG2 . VAL A 1 331 ? 25.302  -25.710 15.895  1.00 58.62  ? 325 VAL A CG2 1 
ATOM 2464  N N   . PHE A 1 332 ? 28.890  -23.978 18.258  1.00 43.82  ? 326 PHE A N   1 
ATOM 2465  C CA  . PHE A 1 332 ? 29.485  -23.283 19.411  1.00 44.33  ? 326 PHE A CA  1 
ATOM 2466  C C   . PHE A 1 332 ? 30.034  -21.965 18.995  1.00 46.12  ? 326 PHE A C   1 
ATOM 2467  O O   . PHE A 1 332 ? 29.784  -20.945 19.647  1.00 51.63  ? 326 PHE A O   1 
ATOM 2468  C CB  . PHE A 1 332 ? 30.640  -24.171 19.856  1.00 46.55  ? 326 PHE A CB  1 
ATOM 2469  C CG  . PHE A 1 332 ? 31.210  -23.862 21.230  1.00 50.46  ? 326 PHE A CG  1 
ATOM 2470  C CD1 . PHE A 1 332 ? 30.487  -24.144 22.379  1.00 48.45  ? 326 PHE A CD1 1 
ATOM 2471  C CD2 . PHE A 1 332 ? 32.468  -23.294 21.367  1.00 54.80  ? 326 PHE A CD2 1 
ATOM 2472  C CE1 . PHE A 1 332 ? 31.006  -23.862 23.627  1.00 48.93  ? 326 PHE A CE1 1 
ATOM 2473  C CE2 . PHE A 1 332 ? 32.983  -23.017 22.619  1.00 53.30  ? 326 PHE A CE2 1 
ATOM 2474  C CZ  . PHE A 1 332 ? 32.251  -23.300 23.745  1.00 51.52  ? 326 PHE A CZ  1 
ATOM 2475  N N   . LEU A 1 333 ? 30.709  -21.957 17.860  1.00 45.45  ? 327 LEU A N   1 
ATOM 2476  C CA  . LEU A 1 333 ? 31.272  -20.692 17.359  1.00 42.40  ? 327 LEU A CA  1 
ATOM 2477  C C   . LEU A 1 333 ? 30.135  -19.738 17.039  1.00 37.53  ? 327 LEU A C   1 
ATOM 2478  O O   . LEU A 1 333 ? 30.235  -18.562 17.371  1.00 34.06  ? 327 LEU A O   1 
ATOM 2479  C CB  . LEU A 1 333 ? 32.181  -21.002 16.180  1.00 45.17  ? 327 LEU A CB  1 
ATOM 2480  C CG  . LEU A 1 333 ? 33.556  -21.567 16.543  1.00 53.51  ? 327 LEU A CG  1 
ATOM 2481  C CD1 . LEU A 1 333 ? 34.344  -21.879 15.290  1.00 55.85  ? 327 LEU A CD1 1 
ATOM 2482  C CD2 . LEU A 1 333 ? 34.305  -20.581 17.412  1.00 56.69  ? 327 LEU A CD2 1 
ATOM 2483  N N   . GLY A 1 334 ? 29.079  -20.264 16.443  1.00 42.17  ? 328 GLY A N   1 
ATOM 2484  C CA  . GLY A 1 334 ? 27.935  -19.427 16.057  1.00 46.51  ? 328 GLY A CA  1 
ATOM 2485  C C   . GLY A 1 334 ? 27.290  -18.824 17.257  1.00 44.17  ? 328 GLY A C   1 
ATOM 2486  O O   . GLY A 1 334 ? 26.941  -17.645 17.201  1.00 43.42  ? 328 GLY A O   1 
ATOM 2487  N N   . MET A 1 335 ? 27.151  -19.603 18.316  1.00 48.68  ? 329 MET A N   1 
ATOM 2488  C CA  . MET A 1 335 ? 26.618  -19.052 19.580  1.00 55.79  ? 329 MET A CA  1 
ATOM 2489  C C   . MET A 1 335 ? 27.556  -17.979 20.147  1.00 50.12  ? 329 MET A C   1 
ATOM 2490  O O   . MET A 1 335 ? 27.050  -16.975 20.645  1.00 44.72  ? 329 MET A O   1 
ATOM 2491  C CB  . MET A 1 335 ? 26.420  -20.189 20.582  1.00 60.28  ? 329 MET A CB  1 
ATOM 2492  C CG  . MET A 1 335 ? 25.332  -21.153 20.182  1.00 67.03  ? 329 MET A CG  1 
ATOM 2493  S SD  . MET A 1 335 ? 24.334  -21.659 21.592  1.00 93.83  ? 329 MET A SD  1 
ATOM 2494  C CE  . MET A 1 335 ? 23.960  -20.059 22.320  1.00 101.72 ? 329 MET A CE  1 
ATOM 2495  N N   . PHE A 1 336 ? 28.866  -18.205 20.097  1.00 47.58  ? 330 PHE A N   1 
ATOM 2496  C CA  . PHE A 1 336 ? 29.787  -17.216 20.696  1.00 45.75  ? 330 PHE A CA  1 
ATOM 2497  C C   . PHE A 1 336 ? 29.657  -15.924 19.953  1.00 47.18  ? 330 PHE A C   1 
ATOM 2498  O O   . PHE A 1 336 ? 29.617  -14.857 20.575  1.00 47.69  ? 330 PHE A O   1 
ATOM 2499  C CB  . PHE A 1 336 ? 31.211  -17.753 20.575  1.00 44.20  ? 330 PHE A CB  1 
ATOM 2500  C CG  . PHE A 1 336 ? 32.314  -16.718 20.704  1.00 48.86  ? 330 PHE A CG  1 
ATOM 2501  C CD1 . PHE A 1 336 ? 32.725  -16.271 21.950  1.00 59.29  ? 330 PHE A CD1 1 
ATOM 2502  C CD2 . PHE A 1 336 ? 32.940  -16.204 19.579  1.00 52.65  ? 330 PHE A CD2 1 
ATOM 2503  C CE1 . PHE A 1 336 ? 33.732  -15.331 22.063  1.00 64.99  ? 330 PHE A CE1 1 
ATOM 2504  C CE2 . PHE A 1 336 ? 33.942  -15.261 19.699  1.00 55.57  ? 330 PHE A CE2 1 
ATOM 2505  C CZ  . PHE A 1 336 ? 34.338  -14.830 20.939  1.00 62.04  ? 330 PHE A CZ  1 
ATOM 2506  N N   . LEU A 1 337 ? 29.574  -16.011 18.631  1.00 45.86  ? 331 LEU A N   1 
ATOM 2507  C CA  . LEU A 1 337 ? 29.363  -14.793 17.822  1.00 46.34  ? 331 LEU A CA  1 
ATOM 2508  C C   . LEU A 1 337 ? 28.007  -14.158 18.135  1.00 50.54  ? 331 LEU A C   1 
ATOM 2509  O O   . LEU A 1 337 ? 27.936  -12.930 18.249  1.00 56.09  ? 331 LEU A O   1 
ATOM 2510  C CB  . LEU A 1 337 ? 29.489  -15.174 16.353  1.00 46.02  ? 331 LEU A CB  1 
ATOM 2511  C CG  . LEU A 1 337 ? 29.520  -14.031 15.339  1.00 48.24  ? 331 LEU A CG  1 
ATOM 2512  C CD1 . LEU A 1 337 ? 30.743  -13.168 15.545  1.00 50.48  ? 331 LEU A CD1 1 
ATOM 2513  C CD2 . LEU A 1 337 ? 29.537  -14.649 13.961  1.00 48.62  ? 331 LEU A CD2 1 
ATOM 2514  N N   . TYR A 1 338 ? 26.967  -14.963 18.277  1.00 50.60  ? 332 TYR A N   1 
ATOM 2515  C CA  . TYR A 1 338 ? 25.651  -14.330 18.487  1.00 51.71  ? 332 TYR A CA  1 
ATOM 2516  C C   . TYR A 1 338 ? 25.659  -13.575 19.772  1.00 59.22  ? 332 TYR A C   1 
ATOM 2517  O O   . TYR A 1 338 ? 25.134  -12.462 19.852  1.00 63.63  ? 332 TYR A O   1 
ATOM 2518  C CB  . TYR A 1 338 ? 24.683  -15.505 18.556  1.00 53.40  ? 332 TYR A CB  1 
ATOM 2519  C CG  . TYR A 1 338 ? 23.367  -15.335 19.300  1.00 57.21  ? 332 TYR A CG  1 
ATOM 2520  C CD1 . TYR A 1 338 ? 22.259  -14.788 18.670  1.00 61.27  ? 332 TYR A CD1 1 
ATOM 2521  C CD2 . TYR A 1 338 ? 23.217  -15.774 20.608  1.00 52.17  ? 332 TYR A CD2 1 
ATOM 2522  C CE1 . TYR A 1 338 ? 21.052  -14.644 19.329  1.00 60.00  ? 332 TYR A CE1 1 
ATOM 2523  C CE2 . TYR A 1 338 ? 22.014  -15.638 21.278  1.00 52.83  ? 332 TYR A CE2 1 
ATOM 2524  C CZ  . TYR A 1 338 ? 20.929  -15.073 20.635  1.00 58.37  ? 332 TYR A CZ  1 
ATOM 2525  O OH  . TYR A 1 338 ? 19.735  -14.928 21.270  1.00 60.83  ? 332 TYR A OH  1 
ATOM 2526  N N   . GLU A 1 339 ? 26.244  -14.185 20.794  1.00 61.39  ? 333 GLU A N   1 
ATOM 2527  C CA  . GLU A 1 339 ? 26.256  -13.525 22.115  1.00 63.26  ? 333 GLU A CA  1 
ATOM 2528  C C   . GLU A 1 339 ? 27.066  -12.230 22.046  1.00 57.60  ? 333 GLU A C   1 
ATOM 2529  O O   . GLU A 1 339 ? 26.633  -11.225 22.608  1.00 55.27  ? 333 GLU A O   1 
ATOM 2530  C CB  . GLU A 1 339 ? 26.758  -14.526 23.151  1.00 69.04  ? 333 GLU A CB  1 
ATOM 2531  C CG  . GLU A 1 339 ? 25.842  -15.732 23.325  1.00 75.76  ? 333 GLU A CG  1 
ATOM 2532  C CD  . GLU A 1 339 ? 24.612  -15.513 24.183  1.00 78.26  ? 333 GLU A CD  1 
ATOM 2533  O OE1 . GLU A 1 339 ? 24.386  -14.378 24.641  1.00 75.33  ? 333 GLU A OE1 1 
ATOM 2534  O OE2 . GLU A 1 339 ? 23.873  -16.493 24.392  1.00 77.34  ? 333 GLU A OE2 1 
ATOM 2535  N N   . TYR A 1 340 ? 28.202  -12.261 21.369  1.00 50.27  ? 334 TYR A N   1 
ATOM 2536  C CA  . TYR A 1 340 ? 29.006  -11.027 21.349  1.00 46.62  ? 334 TYR A CA  1 
ATOM 2537  C C   . TYR A 1 340 ? 28.217  -9.975  20.649  1.00 45.36  ? 334 TYR A C   1 
ATOM 2538  O O   . TYR A 1 340 ? 28.182  -8.826  21.075  1.00 45.72  ? 334 TYR A O   1 
ATOM 2539  C CB  . TYR A 1 340 ? 30.301  -11.380 20.629  1.00 47.21  ? 334 TYR A CB  1 
ATOM 2540  C CG  . TYR A 1 340 ? 31.577  -10.832 21.249  1.00 51.36  ? 334 TYR A CG  1 
ATOM 2541  C CD1 . TYR A 1 340 ? 31.606  -9.573  21.831  1.00 50.88  ? 334 TYR A CD1 1 
ATOM 2542  C CD2 . TYR A 1 340 ? 32.753  -11.568 21.236  1.00 48.84  ? 334 TYR A CD2 1 
ATOM 2543  C CE1 . TYR A 1 340 ? 32.766  -9.066  22.389  1.00 49.67  ? 334 TYR A CE1 1 
ATOM 2544  C CE2 . TYR A 1 340 ? 33.919  -11.072 21.791  1.00 47.87  ? 334 TYR A CE2 1 
ATOM 2545  C CZ  . TYR A 1 340 ? 33.924  -9.817  22.367  1.00 47.04  ? 334 TYR A CZ  1 
ATOM 2546  O OH  . TYR A 1 340 ? 35.061  -9.314  22.918  1.00 46.31  ? 334 TYR A OH  1 
ATOM 2547  N N   . ALA A 1 341 ? 27.569  -10.372 19.564  1.00 46.29  ? 335 ALA A N   1 
ATOM 2548  C CA  . ALA A 1 341 ? 26.859  -9.375  18.743  1.00 45.24  ? 335 ALA A CA  1 
ATOM 2549  C C   . ALA A 1 341 ? 25.714  -8.696  19.483  1.00 44.65  ? 335 ALA A C   1 
ATOM 2550  O O   . ALA A 1 341 ? 25.562  -7.489  19.347  1.00 46.16  ? 335 ALA A O   1 
ATOM 2551  C CB  . ALA A 1 341 ? 26.360  -10.071 17.518  1.00 44.29  ? 335 ALA A CB  1 
ATOM 2552  N N   . ARG A 1 342 ? 24.930  -9.454  20.235  1.00 46.25  ? 336 ARG A N   1 
ATOM 2553  C CA  . ARG A 1 342 ? 23.771  -8.848  20.930  1.00 51.01  ? 336 ARG A CA  1 
ATOM 2554  C C   . ARG A 1 342 ? 24.338  -7.847  21.921  1.00 52.13  ? 336 ARG A C   1 
ATOM 2555  O O   . ARG A 1 342 ? 23.757  -6.775  22.100  1.00 49.82  ? 336 ARG A O   1 
ATOM 2556  C CB  . ARG A 1 342 ? 22.932  -9.946  21.582  1.00 51.29  ? 336 ARG A CB  1 
ATOM 2557  C CG  . ARG A 1 342 ? 23.609  -11.025 22.409  1.00 56.50  ? 336 ARG A CG  1 
ATOM 2558  C CD  . ARG A 1 342 ? 22.779  -12.294 22.459  1.00 57.59  ? 336 ARG A CD  1 
ATOM 2559  N NE  . ARG A 1 342 ? 21.439  -12.096 23.020  1.00 55.54  ? 336 ARG A NE  1 
ATOM 2560  C CZ  . ARG A 1 342 ? 20.811  -12.978 23.783  1.00 53.52  ? 336 ARG A CZ  1 
ATOM 2561  N NH1 . ARG A 1 342 ? 21.501  -13.860 24.478  1.00 50.55  ? 336 ARG A NH1 1 
ATOM 2562  N NH2 . ARG A 1 342 ? 19.496  -12.973 23.849  1.00 49.99  ? 336 ARG A NH2 1 
ATOM 2563  N N   . ARG A 1 343 ? 25.414  -8.245  22.566  1.00 52.56  ? 337 ARG A N   1 
ATOM 2564  C CA  . ARG A 1 343 ? 26.128  -7.415  23.554  1.00 54.17  ? 337 ARG A CA  1 
ATOM 2565  C C   . ARG A 1 343 ? 26.710  -6.173  22.896  1.00 55.68  ? 337 ARG A C   1 
ATOM 2566  O O   . ARG A 1 343 ? 26.711  -5.120  23.544  1.00 67.73  ? 337 ARG A O   1 
ATOM 2567  C CB  . ARG A 1 343 ? 27.135  -8.338  24.242  1.00 56.27  ? 337 ARG A CB  1 
ATOM 2568  C CG  . ARG A 1 343 ? 26.485  -9.176  25.331  1.00 54.38  ? 337 ARG A CG  1 
ATOM 2569  C CD  . ARG A 1 343 ? 27.474  -10.137 25.950  1.00 58.57  ? 337 ARG A CD  1 
ATOM 2570  N NE  . ARG A 1 343 ? 26.868  -10.946 27.010  1.00 65.65  ? 337 ARG A NE  1 
ATOM 2571  C CZ  . ARG A 1 343 ? 26.224  -12.083 26.807  1.00 75.37  ? 337 ARG A CZ  1 
ATOM 2572  N NH1 . ARG A 1 343 ? 25.457  -12.228 25.745  1.00 80.16  ? 337 ARG A NH1 1 
ATOM 2573  N NH2 . ARG A 1 343 ? 26.350  -13.075 27.665  1.00 79.12  ? 337 ARG A NH2 1 
ATOM 2574  N N   . HIS A 1 344 ? 27.225  -6.298  21.682  1.00 56.66  ? 338 HIS A N   1 
ATOM 2575  C CA  . HIS A 1 344 ? 27.988  -5.169  21.096  1.00 57.07  ? 338 HIS A CA  1 
ATOM 2576  C C   . HIS A 1 344 ? 27.491  -4.777  19.713  1.00 59.81  ? 338 HIS A C   1 
ATOM 2577  O O   . HIS A 1 344 ? 28.146  -5.046  18.709  1.00 64.23  ? 338 HIS A O   1 
ATOM 2578  C CB  . HIS A 1 344 ? 29.475  -5.519  21.082  1.00 52.09  ? 338 HIS A CB  1 
ATOM 2579  C CG  . HIS A 1 344 ? 30.040  -5.620  22.449  1.00 52.86  ? 338 HIS A CG  1 
ATOM 2580  N ND1 . HIS A 1 344 ? 30.610  -4.548  23.094  1.00 54.78  ? 338 HIS A ND1 1 
ATOM 2581  C CD2 . HIS A 1 344 ? 30.105  -6.642  23.296  1.00 48.44  ? 338 HIS A CD2 1 
ATOM 2582  C CE1 . HIS A 1 344 ? 31.014  -4.931  24.291  1.00 55.18  ? 338 HIS A CE1 1 
ATOM 2583  N NE2 . HIS A 1 344 ? 30.717  -6.200  24.435  1.00 53.60  ? 338 HIS A NE2 1 
ATOM 2584  N N   . PRO A 1 345 ? 26.371  -4.044  19.647  1.00 65.80  ? 339 PRO A N   1 
ATOM 2585  C CA  . PRO A 1 345 ? 25.836  -3.499  18.410  1.00 65.19  ? 339 PRO A CA  1 
ATOM 2586  C C   . PRO A 1 345 ? 26.883  -2.541  17.879  1.00 59.26  ? 339 PRO A C   1 
ATOM 2587  O O   . PRO A 1 345 ? 26.993  -2.422  16.662  1.00 52.42  ? 339 PRO A O   1 
ATOM 2588  C CB  . PRO A 1 345 ? 24.536  -2.858  18.852  1.00 66.84  ? 339 PRO A CB  1 
ATOM 2589  C CG  . PRO A 1 345 ? 24.165  -3.633  20.086  1.00 69.79  ? 339 PRO A CG  1 
ATOM 2590  C CD  . PRO A 1 345 ? 25.508  -3.751  20.773  1.00 66.22  ? 339 PRO A CD  1 
ATOM 2591  N N   . ASP A 1 346 ? 27.569  -1.813  18.750  1.00 55.84  ? 340 ASP A N   1 
ATOM 2592  C CA  . ASP A 1 346 ? 28.537  -0.762  18.364  1.00 55.77  ? 340 ASP A CA  1 
ATOM 2593  C C   . ASP A 1 346 ? 29.671  -1.369  17.550  1.00 56.27  ? 340 ASP A C   1 
ATOM 2594  O O   . ASP A 1 346 ? 30.216  -0.667  16.704  1.00 60.83  ? 340 ASP A O   1 
ATOM 2595  C CB  . ASP A 1 346 ? 29.150  -0.127  19.590  1.00 61.51  ? 340 ASP A CB  1 
ATOM 2596  C CG  . ASP A 1 346 ? 29.953  -1.049  20.491  1.00 70.14  ? 340 ASP A CG  1 
ATOM 2597  O OD1 . ASP A 1 346 ? 29.381  -2.045  20.965  1.00 73.40  ? 340 ASP A OD1 1 
ATOM 2598  O OD2 . ASP A 1 346 ? 31.143  -0.755  20.710  1.00 76.36  ? 340 ASP A OD2 1 
ATOM 2599  N N   . TYR A 1 347 ? 30.116  -2.555  17.902  1.00 53.97  ? 341 TYR A N   1 
ATOM 2600  C CA  . TYR A 1 347 ? 31.224  -3.202  17.174  1.00 58.64  ? 341 TYR A CA  1 
ATOM 2601  C C   . TYR A 1 347 ? 30.833  -3.497  15.733  1.00 69.25  ? 341 TYR A C   1 
ATOM 2602  O O   . TYR A 1 347 ? 29.671  -3.837  15.474  1.00 66.59  ? 341 TYR A O   1 
ATOM 2603  C CB  . TYR A 1 347 ? 31.538  -4.535  17.849  1.00 58.77  ? 341 TYR A CB  1 
ATOM 2604  C CG  . TYR A 1 347 ? 32.309  -4.556  19.160  1.00 56.90  ? 341 TYR A CG  1 
ATOM 2605  C CD1 . TYR A 1 347 ? 32.516  -3.409  19.909  1.00 57.89  ? 341 TYR A CD1 1 
ATOM 2606  C CD2 . TYR A 1 347 ? 32.824  -5.747  19.647  1.00 57.51  ? 341 TYR A CD2 1 
ATOM 2607  C CE1 . TYR A 1 347 ? 33.213  -3.448  21.104  1.00 56.89  ? 341 TYR A CE1 1 
ATOM 2608  C CE2 . TYR A 1 347 ? 33.525  -5.801  20.837  1.00 56.58  ? 341 TYR A CE2 1 
ATOM 2609  C CZ  . TYR A 1 347 ? 33.717  -4.648  21.570  1.00 56.70  ? 341 TYR A CZ  1 
ATOM 2610  O OH  . TYR A 1 347 ? 34.404  -4.714  22.744  1.00 51.03  ? 341 TYR A OH  1 
ATOM 2611  N N   . SER A 1 348 ? 31.773  -3.337  14.801  1.00 71.48  ? 342 SER A N   1 
ATOM 2612  C CA  . SER A 1 348 ? 31.585  -3.648  13.361  1.00 64.22  ? 342 SER A CA  1 
ATOM 2613  C C   . SER A 1 348 ? 31.450  -5.152  13.148  1.00 61.59  ? 342 SER A C   1 
ATOM 2614  O O   . SER A 1 348 ? 32.080  -5.904  13.897  1.00 64.30  ? 342 SER A O   1 
ATOM 2615  C CB  . SER A 1 348 ? 32.734  -3.154  12.568  1.00 64.01  ? 342 SER A CB  1 
ATOM 2616  O OG  . SER A 1 348 ? 33.962  -3.566  13.145  1.00 64.51  ? 342 SER A OG  1 
ATOM 2617  N N   . VAL A 1 349 ? 30.703  -5.560  12.133  1.00 52.86  ? 343 VAL A N   1 
ATOM 2618  C CA  . VAL A 1 349 ? 30.446  -7.001  11.872  1.00 44.26  ? 343 VAL A CA  1 
ATOM 2619  C C   . VAL A 1 349 ? 31.813  -7.634  11.585  1.00 45.91  ? 343 VAL A C   1 
ATOM 2620  O O   . VAL A 1 349 ? 32.031  -8.774  12.002  1.00 45.38  ? 343 VAL A O   1 
ATOM 2621  C CB  . VAL A 1 349 ? 29.393  -7.216  10.771  1.00 40.14  ? 343 VAL A CB  1 
ATOM 2622  C CG1 . VAL A 1 349 ? 29.110  -8.691  10.545  1.00 44.02  ? 343 VAL A CG1 1 
ATOM 2623  C CG2 . VAL A 1 349 ? 28.103  -6.473  11.080  1.00 38.10  ? 343 VAL A CG2 1 
ATOM 2624  N N   . VAL A 1 350 ? 32.679  -6.939  10.871  1.00 50.95  ? 344 VAL A N   1 
ATOM 2625  C CA  . VAL A 1 350 ? 34.061  -7.441  10.606  1.00 58.44  ? 344 VAL A CA  1 
ATOM 2626  C C   . VAL A 1 350 ? 34.889  -7.611  11.895  1.00 51.63  ? 344 VAL A C   1 
ATOM 2627  O O   . VAL A 1 350 ? 35.622  -8.597  11.971  1.00 44.85  ? 344 VAL A O   1 
ATOM 2628  C CB  . VAL A 1 350 ? 34.749  -6.471  9.633   1.00 69.93  ? 344 VAL A CB  1 
ATOM 2629  C CG1 . VAL A 1 350 ? 34.580  -6.912  8.186   1.00 70.08  ? 344 VAL A CG1 1 
ATOM 2630  C CG2 . VAL A 1 350 ? 34.251  -5.046  9.812   1.00 80.80  ? 344 VAL A CG2 1 
ATOM 2631  N N   . LEU A 1 351 ? 34.797  -6.697  12.856  1.00 48.62  ? 345 LEU A N   1 
ATOM 2632  C CA  . LEU A 1 351 ? 35.544  -6.882  14.119  1.00 50.62  ? 345 LEU A CA  1 
ATOM 2633  C C   . LEU A 1 351 ? 35.039  -8.138  14.816  1.00 54.93  ? 345 LEU A C   1 
ATOM 2634  O O   . LEU A 1 351 ? 35.854  -8.908  15.339  1.00 48.37  ? 345 LEU A O   1 
ATOM 2635  C CB  . LEU A 1 351 ? 35.326  -5.679  15.026  1.00 49.50  ? 345 LEU A CB  1 
ATOM 2636  C CG  . LEU A 1 351 ? 35.791  -5.828  16.476  1.00 49.95  ? 345 LEU A CG  1 
ATOM 2637  C CD1 . LEU A 1 351 ? 37.261  -6.163  16.498  1.00 50.40  ? 345 LEU A CD1 1 
ATOM 2638  C CD2 . LEU A 1 351 ? 35.535  -4.546  17.231  1.00 53.31  ? 345 LEU A CD2 1 
ATOM 2639  N N   . LEU A 1 352 ? 33.733  -8.336  14.802  1.00 55.48  ? 346 LEU A N   1 
ATOM 2640  C CA  . LEU A 1 352 ? 33.189  -9.491  15.533  1.00 55.28  ? 346 LEU A CA  1 
ATOM 2641  C C   . LEU A 1 352 ? 33.718  -10.775 14.917  1.00 49.56  ? 346 LEU A C   1 
ATOM 2642  O O   . LEU A 1 352 ? 34.087  -11.693 15.658  1.00 40.77  ? 346 LEU A O   1 
ATOM 2643  C CB  . LEU A 1 352 ? 31.689  -9.337  15.322  1.00 55.92  ? 346 LEU A CB  1 
ATOM 2644  C CG  . LEU A 1 352 ? 30.999  -8.204  16.085  1.00 56.76  ? 346 LEU A CG  1 
ATOM 2645  C CD1 . LEU A 1 352 ? 29.534  -8.174  15.703  1.00 55.29  ? 346 LEU A CD1 1 
ATOM 2646  C CD2 . LEU A 1 352 ? 31.149  -8.398  17.580  1.00 58.05  ? 346 LEU A CD2 1 
ATOM 2647  N N   . LEU A 1 353 ? 33.752  -10.806 13.598  1.00 45.13  ? 347 LEU A N   1 
ATOM 2648  C CA  . LEU A 1 353 ? 34.246  -11.992 12.872  1.00 45.60  ? 347 LEU A CA  1 
ATOM 2649  C C   . LEU A 1 353 ? 35.725  -12.233 13.177  1.00 45.95  ? 347 LEU A C   1 
ATOM 2650  O O   . LEU A 1 353 ? 36.123  -13.385 13.310  1.00 50.20  ? 347 LEU A O   1 
ATOM 2651  C CB  . LEU A 1 353 ? 33.942  -11.778 11.395  1.00 45.80  ? 347 LEU A CB  1 
ATOM 2652  C CG  . LEU A 1 353 ? 32.466  -11.854 10.996  1.00 43.50  ? 347 LEU A CG  1 
ATOM 2653  C CD1 . LEU A 1 353 ? 32.329  -11.947 9.495   1.00 41.69  ? 347 LEU A CD1 1 
ATOM 2654  C CD2 . LEU A 1 353 ? 31.803  -13.039 11.654  1.00 45.10  ? 347 LEU A CD2 1 
ATOM 2655  N N   . ARG A 1 354 ? 36.511  -11.177 13.245  1.00 49.42  ? 348 ARG A N   1 
ATOM 2656  C CA  . ARG A 1 354 ? 37.929  -11.366 13.590  1.00 52.34  ? 348 ARG A CA  1 
ATOM 2657  C C   . ARG A 1 354 ? 38.051  -11.939 14.991  1.00 49.74  ? 348 ARG A C   1 
ATOM 2658  O O   . ARG A 1 354 ? 38.867  -12.835 15.208  1.00 46.76  ? 348 ARG A O   1 
ATOM 2659  C CB  . ARG A 1 354 ? 38.555  -9.977  13.607  1.00 61.89  ? 348 ARG A CB  1 
ATOM 2660  C CG  . ARG A 1 354 ? 38.637  -9.267  12.265  1.00 66.53  ? 348 ARG A CG  1 
ATOM 2661  C CD  . ARG A 1 354 ? 39.384  -7.952  12.389  1.00 70.10  ? 348 ARG A CD  1 
ATOM 2662  N NE  . ARG A 1 354 ? 38.793  -6.876  11.586  1.00 68.46  ? 348 ARG A NE  1 
ATOM 2663  C CZ  . ARG A 1 354 ? 38.664  -5.631  12.012  1.00 77.89  ? 348 ARG A CZ  1 
ATOM 2664  N NH1 . ARG A 1 354 ? 38.954  -5.337  13.264  1.00 82.28  ? 348 ARG A NH1 1 
ATOM 2665  N NH2 . ARG A 1 354 ? 38.246  -4.689  11.189  1.00 76.14  ? 348 ARG A NH2 1 
ATOM 2666  N N   . LEU A 1 355 ? 37.242  -11.435 15.902  1.00 52.63  ? 349 LEU A N   1 
ATOM 2667  C CA  . LEU A 1 355 ? 37.299  -11.922 17.294  1.00 56.31  ? 349 LEU A CA  1 
ATOM 2668  C C   . LEU A 1 355 ? 36.916  -13.402 17.330  1.00 57.29  ? 349 LEU A C   1 
ATOM 2669  O O   . LEU A 1 355 ? 37.575  -14.173 18.031  1.00 54.68  ? 349 LEU A O   1 
ATOM 2670  C CB  . LEU A 1 355 ? 36.327  -11.068 18.100  1.00 59.18  ? 349 LEU A CB  1 
ATOM 2671  C CG  . LEU A 1 355 ? 36.707  -9.604  18.328  1.00 59.44  ? 349 LEU A CG  1 
ATOM 2672  C CD1 . LEU A 1 355 ? 35.568  -8.902  19.032  1.00 60.55  ? 349 LEU A CD1 1 
ATOM 2673  C CD2 . LEU A 1 355 ? 37.967  -9.512  19.152  1.00 59.21  ? 349 LEU A CD2 1 
ATOM 2674  N N   . ALA A 1 356 ? 35.904  -13.780 16.564  1.00 56.69  ? 350 ALA A N   1 
ATOM 2675  C CA  . ALA A 1 356 ? 35.467  -15.189 16.514  1.00 56.22  ? 350 ALA A CA  1 
ATOM 2676  C C   . ALA A 1 356 ? 36.595  -16.044 15.956  1.00 55.99  ? 350 ALA A C   1 
ATOM 2677  O O   . ALA A 1 356 ? 36.829  -17.158 16.432  1.00 52.65  ? 350 ALA A O   1 
ATOM 2678  C CB  . ALA A 1 356 ? 34.230  -15.299 15.671  1.00 50.99  ? 350 ALA A CB  1 
ATOM 2679  N N   . LYS A 1 357 ? 37.267  -15.522 14.945  1.00 55.37  ? 351 LYS A N   1 
ATOM 2680  C CA  . LYS A 1 357 ? 38.349  -16.295 14.317  1.00 59.30  ? 351 LYS A CA  1 
ATOM 2681  C C   . LYS A 1 357 ? 39.417  -16.514 15.367  1.00 60.10  ? 351 LYS A C   1 
ATOM 2682  O O   . LYS A 1 357 ? 39.998  -17.605 15.410  1.00 57.78  ? 351 LYS A O   1 
ATOM 2683  C CB  . LYS A 1 357 ? 38.951  -15.482 13.179  1.00 66.37  ? 351 LYS A CB  1 
ATOM 2684  C CG  . LYS A 1 357 ? 38.642  -15.949 11.768  1.00 69.79  ? 351 LYS A CG  1 
ATOM 2685  C CD  . LYS A 1 357 ? 39.066  -14.920 10.728  1.00 72.15  ? 351 LYS A CD  1 
ATOM 2686  C CE  . LYS A 1 357 ? 39.721  -15.538 9.539   1.00 76.20  ? 351 LYS A CE  1 
ATOM 2687  N NZ  . LYS A 1 357 ? 40.514  -14.565 8.785   1.00 80.73  ? 351 LYS A NZ  1 
ATOM 2688  N N   . THR A 1 358 ? 39.676  -15.478 16.154  1.00 66.39  ? 352 THR A N   1 
ATOM 2689  C CA  . THR A 1 358 ? 40.716  -15.580 17.184  1.00 64.96  ? 352 THR A CA  1 
ATOM 2690  C C   . THR A 1 358 ? 40.307  -16.639 18.178  1.00 64.86  ? 352 THR A C   1 
ATOM 2691  O O   . THR A 1 358 ? 41.180  -17.391 18.626  1.00 60.14  ? 352 THR A O   1 
ATOM 2692  C CB  . THR A 1 358 ? 40.911  -14.203 17.811  1.00 59.03  ? 352 THR A CB  1 
ATOM 2693  O OG1 . THR A 1 358 ? 41.123  -13.323 16.714  1.00 51.65  ? 352 THR A OG1 1 
ATOM 2694  C CG2 . THR A 1 358 ? 42.098  -14.150 18.754  1.00 58.72  ? 352 THR A CG2 1 
ATOM 2695  N N   . TYR A 1 359 ? 39.027  -16.667 18.539  1.00 58.35  ? 353 TYR A N   1 
ATOM 2696  C CA  . TYR A 1 359 ? 38.561  -17.661 19.530  1.00 57.75  ? 353 TYR A CA  1 
ATOM 2697  C C   . TYR A 1 359 ? 38.724  -19.055 19.006  1.00 57.43  ? 353 TYR A C   1 
ATOM 2698  O O   . TYR A 1 359 ? 39.195  -19.942 19.718  1.00 56.24  ? 353 TYR A O   1 
ATOM 2699  C CB  . TYR A 1 359 ? 37.082  -17.405 19.795  1.00 63.15  ? 353 TYR A CB  1 
ATOM 2700  C CG  . TYR A 1 359 ? 36.454  -18.163 20.952  1.00 62.34  ? 353 TYR A CG  1 
ATOM 2701  C CD1 . TYR A 1 359 ? 37.126  -18.322 22.153  1.00 64.56  ? 353 TYR A CD1 1 
ATOM 2702  C CD2 . TYR A 1 359 ? 35.181  -18.701 20.841  1.00 64.43  ? 353 TYR A CD2 1 
ATOM 2703  C CE1 . TYR A 1 359 ? 36.553  -19.005 23.210  1.00 68.63  ? 353 TYR A CE1 1 
ATOM 2704  C CE2 . TYR A 1 359 ? 34.596  -19.385 21.890  1.00 73.53  ? 353 TYR A CE2 1 
ATOM 2705  C CZ  . TYR A 1 359 ? 35.285  -19.535 23.077  1.00 71.80  ? 353 TYR A CZ  1 
ATOM 2706  O OH  . TYR A 1 359 ? 34.718  -20.209 24.112  1.00 66.06  ? 353 TYR A OH  1 
ATOM 2707  N N   . GLU A 1 360 ? 38.383  -19.240 17.741  1.00 57.01  ? 354 GLU A N   1 
ATOM 2708  C CA  . GLU A 1 360 ? 38.522  -20.584 17.149  1.00 55.73  ? 354 GLU A CA  1 
ATOM 2709  C C   . GLU A 1 360 ? 39.997  -20.930 17.159  1.00 49.14  ? 354 GLU A C   1 
ATOM 2710  O O   . GLU A 1 360 ? 40.333  -22.066 17.465  1.00 53.93  ? 354 GLU A O   1 
ATOM 2711  C CB  . GLU A 1 360 ? 37.913  -20.609 15.756  1.00 69.81  ? 354 GLU A CB  1 
ATOM 2712  C CG  . GLU A 1 360 ? 38.897  -20.949 14.643  1.00 79.38  ? 354 GLU A CG  1 
ATOM 2713  C CD  . GLU A 1 360 ? 38.587  -20.214 13.354  1.00 88.31  ? 354 GLU A CD  1 
ATOM 2714  O OE1 . GLU A 1 360 ? 39.451  -19.451 12.878  1.00 83.00  ? 354 GLU A OE1 1 
ATOM 2715  O OE2 . GLU A 1 360 ? 37.472  -20.406 12.833  1.00 100.49 ? 354 GLU A OE2 1 
ATOM 2716  N N   . THR A 1 361 ? 40.838  -19.964 16.833  1.00 48.66  ? 355 THR A N   1 
ATOM 2717  C CA  . THR A 1 361 ? 42.244  -20.316 16.762  1.00 54.03  ? 355 THR A CA  1 
ATOM 2718  C C   . THR A 1 361 ? 42.678  -20.728 18.126  1.00 59.69  ? 355 THR A C   1 
ATOM 2719  O O   . THR A 1 361 ? 43.375  -21.744 18.241  1.00 57.04  ? 355 THR A O   1 
ATOM 2720  C CB  . THR A 1 361 ? 42.994  -19.070 16.317  1.00 57.01  ? 355 THR A CB  1 
ATOM 2721  O OG1 . THR A 1 361 ? 42.303  -18.620 15.157  1.00 62.53  ? 355 THR A OG1 1 
ATOM 2722  C CG2 . THR A 1 361 ? 44.448  -19.348 15.993  1.00 53.82  ? 355 THR A CG2 1 
ATOM 2723  N N   . THR A 1 362 ? 42.236  -19.981 19.139  1.00 65.73  ? 356 THR A N   1 
ATOM 2724  C CA  . THR A 1 362 ? 42.673  -20.278 20.515  1.00 69.71  ? 356 THR A CA  1 
ATOM 2725  C C   . THR A 1 362 ? 42.185  -21.633 20.932  1.00 59.02  ? 356 THR A C   1 
ATOM 2726  O O   . THR A 1 362 ? 42.942  -22.395 21.542  1.00 49.39  ? 356 THR A O   1 
ATOM 2727  C CB  . THR A 1 362 ? 42.174  -19.189 21.459  1.00 64.88  ? 356 THR A CB  1 
ATOM 2728  O OG1 . THR A 1 362 ? 40.770  -19.133 21.254  1.00 62.85  ? 356 THR A OG1 1 
ATOM 2729  C CG2 . THR A 1 362 ? 42.812  -17.844 21.169  1.00 66.74  ? 356 THR A CG2 1 
ATOM 2730  N N   . LEU A 1 363 ? 40.947  -21.932 20.591  1.00 51.45  ? 357 LEU A N   1 
ATOM 2731  C CA  . LEU A 1 363 ? 40.429  -23.205 21.096  1.00 53.90  ? 357 LEU A CA  1 
ATOM 2732  C C   . LEU A 1 363 ? 41.271  -24.308 20.484  1.00 58.64  ? 357 LEU A C   1 
ATOM 2733  O O   . LEU A 1 363 ? 41.545  -25.284 21.173  1.00 66.82  ? 357 LEU A O   1 
ATOM 2734  C CB  . LEU A 1 363 ? 38.967  -23.290 20.689  1.00 56.76  ? 357 LEU A CB  1 
ATOM 2735  C CG  . LEU A 1 363 ? 38.000  -22.414 21.487  1.00 60.01  ? 357 LEU A CG  1 
ATOM 2736  C CD1 . LEU A 1 363 ? 36.565  -22.810 21.221  1.00 60.14  ? 357 LEU A CD1 1 
ATOM 2737  C CD2 . LEU A 1 363 ? 38.318  -22.517 22.961  1.00 60.79  ? 357 LEU A CD2 1 
ATOM 2738  N N   . GLU A 1 364 ? 41.670  -24.151 19.241  1.00 59.10  ? 358 GLU A N   1 
ATOM 2739  C CA  . GLU A 1 364 ? 42.378  -25.285 18.611  1.00 69.42  ? 358 GLU A CA  1 
ATOM 2740  C C   . GLU A 1 364 ? 43.746  -25.452 19.279  1.00 69.44  ? 358 GLU A C   1 
ATOM 2741  O O   . GLU A 1 364 ? 44.126  -26.599 19.533  1.00 64.15  ? 358 GLU A O   1 
ATOM 2742  C CB  . GLU A 1 364 ? 42.458  -25.105 17.097  1.00 74.98  ? 358 GLU A CB  1 
ATOM 2743  C CG  . GLU A 1 364 ? 41.096  -25.099 16.411  1.00 75.67  ? 358 GLU A CG  1 
ATOM 2744  C CD  . GLU A 1 364 ? 40.402  -26.445 16.375  1.00 80.60  ? 358 GLU A CD  1 
ATOM 2745  O OE1 . GLU A 1 364 ? 41.077  -27.477 16.551  1.00 80.85  ? 358 GLU A OE1 1 
ATOM 2746  O OE2 . GLU A 1 364 ? 39.175  -26.454 16.169  1.00 87.07  ? 358 GLU A OE2 1 
ATOM 2747  N N   . LYS A 1 365 ? 44.515  -24.382 19.433  1.00 66.97  ? 359 LYS A N   1 
ATOM 2748  C CA  . LYS A 1 365 ? 45.794  -24.603 20.134  1.00 70.27  ? 359 LYS A CA  1 
ATOM 2749  C C   . LYS A 1 365 ? 45.574  -25.049 21.574  1.00 73.12  ? 359 LYS A C   1 
ATOM 2750  O O   . LYS A 1 365 ? 46.286  -25.948 22.033  1.00 81.13  ? 359 LYS A O   1 
ATOM 2751  C CB  . LYS A 1 365 ? 46.574  -23.289 20.203  1.00 71.43  ? 359 LYS A CB  1 
ATOM 2752  C CG  . LYS A 1 365 ? 45.868  -22.049 20.709  1.00 81.95  ? 359 LYS A CG  1 
ATOM 2753  C CD  . LYS A 1 365 ? 46.798  -21.160 21.523  1.00 93.97  ? 359 LYS A CD  1 
ATOM 2754  C CE  . LYS A 1 365 ? 46.344  -19.738 21.580  1.00 102.09 ? 359 LYS A CE  1 
ATOM 2755  N NZ  . LYS A 1 365 ? 46.123  -19.185 20.242  1.00 104.64 ? 359 LYS A NZ  1 
ATOM 2756  N N   . CYS A 1 366 ? 44.635  -24.415 22.256  1.00 75.60  ? 360 CYS A N   1 
ATOM 2757  C CA  . CYS A 1 366 ? 44.355  -24.758 23.672  1.00 79.56  ? 360 CYS A CA  1 
ATOM 2758  C C   . CYS A 1 366 ? 43.812  -26.181 23.884  1.00 71.97  ? 360 CYS A C   1 
ATOM 2759  O O   . CYS A 1 366 ? 44.198  -26.818 24.859  1.00 74.52  ? 360 CYS A O   1 
ATOM 2760  C CB  . CYS A 1 366 ? 43.435  -23.711 24.287  1.00 92.00  ? 360 CYS A CB  1 
ATOM 2761  S SG  . CYS A 1 366 ? 44.067  -22.010 24.272  1.00 97.48  ? 360 CYS A SG  1 
ATOM 2762  N N   . CYS A 1 367 ? 42.908  -26.643 23.030  1.00 67.84  ? 361 CYS A N   1 
ATOM 2763  C CA  . CYS A 1 367 ? 42.257  -27.943 23.329  1.00 72.54  ? 361 CYS A CA  1 
ATOM 2764  C C   . CYS A 1 367 ? 43.248  -29.109 23.336  1.00 71.12  ? 361 CYS A C   1 
ATOM 2765  O O   . CYS A 1 367 ? 43.085  -29.988 24.189  1.00 71.95  ? 361 CYS A O   1 
ATOM 2766  C CB  . CYS A 1 367 ? 41.062  -28.174 22.412  1.00 77.73  ? 361 CYS A CB  1 
ATOM 2767  S SG  . CYS A 1 367 ? 39.599  -27.195 22.854  1.00 86.25  ? 361 CYS A SG  1 
ATOM 2768  N N   . ALA A 1 368 ? 44.187  -29.182 22.402  1.00 70.50  ? 362 ALA A N   1 
ATOM 2769  C CA  . ALA A 1 368 ? 45.222  -30.225 22.554  1.00 71.53  ? 362 ALA A CA  1 
ATOM 2770  C C   . ALA A 1 368 ? 46.337  -29.648 23.413  1.00 69.38  ? 362 ALA A C   1 
ATOM 2771  O O   . ALA A 1 368 ? 47.466  -29.495 22.924  1.00 66.09  ? 362 ALA A O   1 
ATOM 2772  C CB  . ALA A 1 368 ? 45.731  -30.619 21.205  1.00 73.23  ? 362 ALA A CB  1 
ATOM 2773  N N   . ALA A 1 369 ? 46.037  -29.388 24.671  1.00 69.58  ? 363 ALA A N   1 
ATOM 2774  C CA  . ALA A 1 369 ? 47.075  -28.855 25.564  1.00 77.06  ? 363 ALA A CA  1 
ATOM 2775  C C   . ALA A 1 369 ? 46.888  -29.376 26.976  1.00 79.48  ? 363 ALA A C   1 
ATOM 2776  O O   . ALA A 1 369 ? 45.759  -29.730 27.327  1.00 83.19  ? 363 ALA A O   1 
ATOM 2777  C CB  . ALA A 1 369 ? 47.022  -27.358 25.544  1.00 75.75  ? 363 ALA A CB  1 
ATOM 2778  N N   . ALA A 1 370 ? 47.959  -29.443 27.748  1.00 72.25  ? 364 ALA A N   1 
ATOM 2779  C CA  . ALA A 1 370 ? 47.798  -29.723 29.181  1.00 66.13  ? 364 ALA A CA  1 
ATOM 2780  C C   . ALA A 1 370 ? 47.143  -28.479 29.756  1.00 67.45  ? 364 ALA A C   1 
ATOM 2781  O O   . ALA A 1 370 ? 47.457  -27.391 29.259  1.00 72.31  ? 364 ALA A O   1 
ATOM 2782  C CB  . ALA A 1 370 ? 49.145  -29.903 29.775  1.00 67.29  ? 364 ALA A CB  1 
ATOM 2783  N N   . ASP A 1 371 ? 46.310  -28.593 30.779  1.00 70.85  ? 365 ASP A N   1 
ATOM 2784  C CA  . ASP A 1 371 ? 45.820  -27.309 31.357  1.00 86.59  ? 365 ASP A CA  1 
ATOM 2785  C C   . ASP A 1 371 ? 45.177  -26.401 30.302  1.00 85.69  ? 365 ASP A C   1 
ATOM 2786  O O   . ASP A 1 371 ? 45.581  -25.229 30.211  1.00 75.36  ? 365 ASP A O   1 
ATOM 2787  C CB  . ASP A 1 371 ? 46.871  -26.639 32.224  1.00 91.57  ? 365 ASP A CB  1 
ATOM 2788  C CG  . ASP A 1 371 ? 46.488  -26.519 33.693  1.00 91.73  ? 365 ASP A CG  1 
ATOM 2789  O OD1 . ASP A 1 371 ? 45.298  -26.736 34.005  1.00 94.25  ? 365 ASP A OD1 1 
ATOM 2790  O OD2 . ASP A 1 371 ? 47.381  -26.215 34.510  1.00 85.97  ? 365 ASP A OD2 1 
ATOM 2791  N N   . PRO A 1 372 ? 44.251  -26.898 29.459  1.00 85.49  ? 366 PRO A N   1 
ATOM 2792  C CA  . PRO A 1 372 ? 43.686  -26.125 28.364  1.00 78.27  ? 366 PRO A CA  1 
ATOM 2793  C C   . PRO A 1 372 ? 42.979  -24.910 28.924  1.00 67.94  ? 366 PRO A C   1 
ATOM 2794  O O   . PRO A 1 372 ? 43.076  -23.835 28.326  1.00 57.83  ? 366 PRO A O   1 
ATOM 2795  C CB  . PRO A 1 372 ? 42.698  -27.105 27.736  1.00 78.39  ? 366 PRO A CB  1 
ATOM 2796  C CG  . PRO A 1 372 ? 43.161  -28.461 28.174  1.00 80.35  ? 366 PRO A CG  1 
ATOM 2797  C CD  . PRO A 1 372 ? 43.643  -28.210 29.578  1.00 81.72  ? 366 PRO A CD  1 
ATOM 2798  N N   . HIS A 1 373 ? 42.302  -25.052 30.050  1.00 66.75  ? 367 HIS A N   1 
ATOM 2799  C CA  . HIS A 1 373 ? 41.528  -23.929 30.628  1.00 70.35  ? 367 HIS A CA  1 
ATOM 2800  C C   . HIS A 1 373 ? 42.507  -22.809 30.945  1.00 66.79  ? 367 HIS A C   1 
ATOM 2801  O O   . HIS A 1 373 ? 42.143  -21.639 30.773  1.00 57.90  ? 367 HIS A O   1 
ATOM 2802  C CB  . HIS A 1 373 ? 40.812  -24.331 31.912  1.00 76.52  ? 367 HIS A CB  1 
ATOM 2803  C CG  . HIS A 1 373 ? 39.878  -23.295 32.425  1.00 79.87  ? 367 HIS A CG  1 
ATOM 2804  N ND1 . HIS A 1 373 ? 40.307  -22.102 32.959  1.00 86.89  ? 367 HIS A ND1 1 
ATOM 2805  C CD2 . HIS A 1 373 ? 38.548  -23.271 32.487  1.00 80.60  ? 367 HIS A CD2 1 
ATOM 2806  C CE1 . HIS A 1 373 ? 39.257  -21.387 33.327  1.00 87.13  ? 367 HIS A CE1 1 
ATOM 2807  N NE2 . HIS A 1 373 ? 38.179  -22.080 33.049  1.00 91.28  ? 367 HIS A NE2 1 
ATOM 2808  N N   . GLU A 1 374 ? 43.691  -23.144 31.432  1.00 66.71  ? 368 GLU A N   1 
ATOM 2809  C CA  . GLU A 1 374 ? 44.649  -22.047 31.655  1.00 70.27  ? 368 GLU A CA  1 
ATOM 2810  C C   . GLU A 1 374 ? 44.994  -21.348 30.336  1.00 77.80  ? 368 GLU A C   1 
ATOM 2811  O O   . GLU A 1 374 ? 45.105  -20.109 30.358  1.00 62.97  ? 368 GLU A O   1 
ATOM 2812  C CB  . GLU A 1 374 ? 45.943  -22.647 32.183  1.00 72.28  ? 368 GLU A CB  1 
ATOM 2813  C CG  . GLU A 1 374 ? 47.025  -21.608 32.459  1.00 77.66  ? 368 GLU A CG  1 
ATOM 2814  C CD  . GLU A 1 374 ? 48.445  -22.104 32.269  1.00 83.85  ? 368 GLU A CD  1 
ATOM 2815  O OE1 . GLU A 1 374 ? 48.998  -21.909 31.169  1.00 87.73  ? 368 GLU A OE1 1 
ATOM 2816  O OE2 . GLU A 1 374 ? 49.002  -22.681 33.223  1.00 85.13  ? 368 GLU A OE2 1 
ATOM 2817  N N   . CYS A 1 375 ? 45.196  -22.083 29.237  1.00 89.10  ? 369 CYS A N   1 
ATOM 2818  C CA  . CYS A 1 375 ? 45.424  -21.405 27.933  1.00 85.06  ? 369 CYS A CA  1 
ATOM 2819  C C   . CYS A 1 375 ? 44.224  -20.579 27.446  1.00 74.27  ? 369 CYS A C   1 
ATOM 2820  O O   . CYS A 1 375 ? 44.444  -19.428 27.040  1.00 62.64  ? 369 CYS A O   1 
ATOM 2821  C CB  . CYS A 1 375 ? 45.644  -22.500 26.895  1.00 84.54  ? 369 CYS A CB  1 
ATOM 2822  S SG  . CYS A 1 375 ? 45.901  -21.984 25.178  1.00 88.50  ? 369 CYS A SG  1 
ATOM 2823  N N   . TYR A 1 376 ? 43.004  -21.112 27.549  1.00 66.95  ? 370 TYR A N   1 
ATOM 2824  C CA  . TYR A 1 376 ? 41.782  -20.343 27.161  1.00 66.91  ? 370 TYR A CA  1 
ATOM 2825  C C   . TYR A 1 376 ? 41.595  -19.152 28.065  1.00 67.92  ? 370 TYR A C   1 
ATOM 2826  O O   . TYR A 1 376 ? 41.153  -18.105 27.598  1.00 60.00  ? 370 TYR A O   1 
ATOM 2827  C CB  . TYR A 1 376 ? 40.374  -20.947 26.995  1.00 65.02  ? 370 TYR A CB  1 
ATOM 2828  C CG  . TYR A 1 376 ? 39.816  -22.209 27.634  1.00 57.90  ? 370 TYR A CG  1 
ATOM 2829  C CD1 . TYR A 1 376 ? 40.167  -23.471 27.182  1.00 61.59  ? 370 TYR A CD1 1 
ATOM 2830  C CD2 . TYR A 1 376 ? 38.816  -22.123 28.589  1.00 55.75  ? 370 TYR A CD2 1 
ATOM 2831  C CE1 . TYR A 1 376 ? 39.602  -24.612 27.727  1.00 58.74  ? 370 TYR A CE1 1 
ATOM 2832  C CE2 . TYR A 1 376 ? 38.247  -23.254 29.145  1.00 61.83  ? 370 TYR A CE2 1 
ATOM 2833  C CZ  . TYR A 1 376 ? 38.638  -24.503 28.710  1.00 59.35  ? 370 TYR A CZ  1 
ATOM 2834  O OH  . TYR A 1 376 ? 38.074  -25.615 29.259  1.00 53.71  ? 370 TYR A OH  1 
ATOM 2835  N N   . ALA A 1 377 ? 41.849  -19.338 29.352  1.00 69.94  ? 371 ALA A N   1 
ATOM 2836  C CA  . ALA A 1 377 ? 41.501  -18.283 30.323  1.00 71.04  ? 371 ALA A CA  1 
ATOM 2837  C C   . ALA A 1 377 ? 42.014  -16.914 29.920  1.00 72.73  ? 371 ALA A C   1 
ATOM 2838  O O   . ALA A 1 377 ? 41.329  -15.920 30.216  1.00 67.24  ? 371 ALA A O   1 
ATOM 2839  C CB  . ALA A 1 377 ? 42.033  -18.661 31.661  1.00 73.94  ? 371 ALA A CB  1 
ATOM 2840  N N   . LYS A 1 378 ? 43.163  -16.852 29.264  1.00 80.21  ? 372 LYS A N   1 
ATOM 2841  C CA  . LYS A 1 378 ? 43.701  -15.516 29.020  1.00 85.90  ? 372 LYS A CA  1 
ATOM 2842  C C   . LYS A 1 378 ? 43.377  -15.045 27.597  1.00 86.99  ? 372 LYS A C   1 
ATOM 2843  O O   . LYS A 1 378 ? 44.220  -14.420 26.959  1.00 84.80  ? 372 LYS A O   1 
ATOM 2844  C CB  . LYS A 1 378 ? 45.210  -15.495 29.313  1.00 81.19  ? 372 LYS A CB  1 
ATOM 2845  C CG  . LYS A 1 378 ? 46.106  -16.209 28.304  1.00 87.30  ? 372 LYS A CG  1 
ATOM 2846  C CD  . LYS A 1 378 ? 47.534  -16.484 28.765  1.00 87.36  ? 372 LYS A CD  1 
ATOM 2847  C CE  . LYS A 1 378 ? 47.615  -17.744 29.567  1.00 92.95  ? 372 LYS A CE  1 
ATOM 2848  N NZ  . LYS A 1 378 ? 49.000  -18.170 29.750  1.00 96.86  ? 372 LYS A NZ  1 
ATOM 2849  N N   . VAL A 1 379 ? 42.141  -15.293 27.127  1.00 86.71  ? 373 VAL A N   1 
ATOM 2850  C CA  . VAL A 1 379 ? 41.796  -15.164 25.715  1.00 80.29  ? 373 VAL A CA  1 
ATOM 2851  C C   . VAL A 1 379 ? 41.273  -13.761 25.438  1.00 81.04  ? 373 VAL A C   1 
ATOM 2852  O O   . VAL A 1 379 ? 41.409  -13.265 24.319  1.00 85.73  ? 373 VAL A O   1 
ATOM 2853  C CB  . VAL A 1 379 ? 40.772  -16.194 25.196  1.00 76.50  ? 373 VAL A CB  1 
ATOM 2854  C CG1 . VAL A 1 379 ? 39.388  -16.034 25.818  1.00 74.61  ? 373 VAL A CG1 1 
ATOM 2855  C CG2 . VAL A 1 379 ? 40.664  -16.142 23.681  1.00 73.52  ? 373 VAL A CG2 1 
ATOM 2856  N N   . PHE A 1 380 ? 40.632  -13.153 26.440  1.00 78.99  ? 374 PHE A N   1 
ATOM 2857  C CA  . PHE A 1 380 ? 40.154  -11.787 26.303  1.00 76.67  ? 374 PHE A CA  1 
ATOM 2858  C C   . PHE A 1 380 ? 41.347  -10.835 26.206  1.00 76.10  ? 374 PHE A C   1 
ATOM 2859  O O   . PHE A 1 380 ? 41.223  -9.754  25.637  1.00 69.60  ? 374 PHE A O   1 
ATOM 2860  C CB  . PHE A 1 380 ? 39.199  -11.436 27.446  1.00 75.47  ? 374 PHE A CB  1 
ATOM 2861  C CG  . PHE A 1 380 ? 37.728  -11.673 27.137  1.00 72.53  ? 374 PHE A CG  1 
ATOM 2862  C CD1 . PHE A 1 380 ? 37.195  -12.956 27.143  1.00 67.32  ? 374 PHE A CD1 1 
ATOM 2863  C CD2 . PHE A 1 380 ? 36.881  -10.602 26.860  1.00 74.47  ? 374 PHE A CD2 1 
ATOM 2864  C CE1 . PHE A 1 380 ? 35.856  -13.158 26.865  1.00 71.71  ? 374 PHE A CE1 1 
ATOM 2865  C CE2 . PHE A 1 380 ? 35.541  -10.811 26.585  1.00 77.82  ? 374 PHE A CE2 1 
ATOM 2866  C CZ  . PHE A 1 380 ? 35.033  -12.089 26.585  1.00 78.89  ? 374 PHE A CZ  1 
ATOM 2867  N N   . ASP A 1 381 ? 42.513  -11.248 26.726  1.00 79.12  ? 375 ASP A N   1 
ATOM 2868  C CA  . ASP A 1 381 ? 43.743  -10.485 26.552  1.00 75.72  ? 375 ASP A CA  1 
ATOM 2869  C C   . ASP A 1 381 ? 44.059  -10.290 25.070  1.00 75.21  ? 375 ASP A C   1 
ATOM 2870  O O   . ASP A 1 381 ? 44.838  -9.406  24.722  1.00 80.59  ? 375 ASP A O   1 
ATOM 2871  C CB  . ASP A 1 381 ? 44.930  -11.108 27.274  1.00 71.19  ? 375 ASP A CB  1 
ATOM 2872  C CG  . ASP A 1 381 ? 45.131  -10.694 28.727  1.00 77.01  ? 375 ASP A CG  1 
ATOM 2873  O OD1 . ASP A 1 381 ? 44.492  -9.719  29.175  1.00 73.76  ? 375 ASP A OD1 1 
ATOM 2874  O OD2 . ASP A 1 381 ? 45.932  -11.355 29.411  1.00 88.30  ? 375 ASP A OD2 1 
ATOM 2875  N N   . GLU A 1 382 ? 43.460  -11.112 24.201  1.00 75.70  ? 376 GLU A N   1 
ATOM 2876  C CA  . GLU A 1 382 ? 43.729  -11.038 22.776  1.00 79.22  ? 376 GLU A CA  1 
ATOM 2877  C C   . GLU A 1 382 ? 42.648  -10.224 22.069  1.00 79.45  ? 376 GLU A C   1 
ATOM 2878  O O   . GLU A 1 382 ? 42.952  -9.511  21.118  1.00 80.63  ? 376 GLU A O   1 
ATOM 2879  C CB  . GLU A 1 382 ? 43.927  -12.447 22.225  1.00 80.44  ? 376 GLU A CB  1 
ATOM 2880  C CG  . GLU A 1 382 ? 45.054  -13.170 22.953  1.00 86.59  ? 376 GLU A CG  1 
ATOM 2881  C CD  . GLU A 1 382 ? 45.492  -14.453 22.291  1.00 94.98  ? 376 GLU A CD  1 
ATOM 2882  O OE1 . GLU A 1 382 ? 46.045  -14.319 21.181  1.00 109.42 ? 376 GLU A OE1 1 
ATOM 2883  O OE2 . GLU A 1 382 ? 45.277  -15.553 22.858  1.00 96.66  ? 376 GLU A OE2 1 
ATOM 2884  N N   . PHE A 1 383 ? 41.400  -10.297 22.543  1.00 79.13  ? 377 PHE A N   1 
ATOM 2885  C CA  . PHE A 1 383 ? 40.320  -9.530  21.932  1.00 75.63  ? 377 PHE A CA  1 
ATOM 2886  C C   . PHE A 1 383 ? 40.565  -8.027  22.101  1.00 71.98  ? 377 PHE A C   1 
ATOM 2887  O O   . PHE A 1 383 ? 40.124  -7.250  21.260  1.00 72.38  ? 377 PHE A O   1 
ATOM 2888  C CB  . PHE A 1 383 ? 38.921  -9.838  22.487  1.00 69.49  ? 377 PHE A CB  1 
ATOM 2889  C CG  . PHE A 1 383 ? 38.452  -11.285 22.429  1.00 61.19  ? 377 PHE A CG  1 
ATOM 2890  C CD1 . PHE A 1 383 ? 39.145  -12.253 21.721  1.00 61.18  ? 377 PHE A CD1 1 
ATOM 2891  C CD2 . PHE A 1 383 ? 37.289  -11.671 23.078  1.00 67.49  ? 377 PHE A CD2 1 
ATOM 2892  C CE1 . PHE A 1 383 ? 38.679  -13.560 21.668  1.00 65.95  ? 377 PHE A CE1 1 
ATOM 2893  C CE2 . PHE A 1 383 ? 36.832  -12.985 23.029  1.00 65.51  ? 377 PHE A CE2 1 
ATOM 2894  C CZ  . PHE A 1 383 ? 37.527  -13.928 22.327  1.00 59.69  ? 377 PHE A CZ  1 
ATOM 2895  N N   . LYS A 1 384 ? 41.235  -7.621  23.194  1.00 69.11  ? 378 LYS A N   1 
ATOM 2896  C CA  . LYS A 1 384 ? 41.349  -6.216  23.571  1.00 68.43  ? 378 LYS A CA  1 
ATOM 2897  C C   . LYS A 1 384 ? 42.002  -5.438  22.419  1.00 60.13  ? 378 LYS A C   1 
ATOM 2898  O O   . LYS A 1 384 ? 41.371  -4.524  21.877  1.00 45.05  ? 378 LYS A O   1 
ATOM 2899  C CB  . LYS A 1 384 ? 42.015  -6.125  24.957  1.00 72.77  ? 378 LYS A CB  1 
ATOM 2900  C CG  . LYS A 1 384 ? 42.273  -4.735  25.545  1.00 78.64  ? 378 LYS A CG  1 
ATOM 2901  C CD  . LYS A 1 384 ? 41.240  -4.259  26.562  1.00 86.50  ? 378 LYS A CD  1 
ATOM 2902  C CE  . LYS A 1 384 ? 41.252  -2.769  26.824  1.00 90.16  ? 378 LYS A CE  1 
ATOM 2903  N NZ  . LYS A 1 384 ? 40.751  -1.951  25.704  1.00 83.61  ? 378 LYS A NZ  1 
ATOM 2904  N N   . PRO A 1 385 ? 43.241  -5.802  21.976  1.00 58.69  ? 379 PRO A N   1 
ATOM 2905  C CA  . PRO A 1 385 ? 43.907  -5.143  20.846  1.00 58.82  ? 379 PRO A CA  1 
ATOM 2906  C C   . PRO A 1 385 ? 43.091  -5.010  19.557  1.00 60.41  ? 379 PRO A C   1 
ATOM 2907  O O   . PRO A 1 385 ? 43.243  -4.041  18.814  1.00 66.14  ? 379 PRO A O   1 
ATOM 2908  C CB  . PRO A 1 385 ? 45.156  -6.015  20.620  1.00 57.16  ? 379 PRO A CB  1 
ATOM 2909  C CG  . PRO A 1 385 ? 45.450  -6.610  21.969  1.00 56.90  ? 379 PRO A CG  1 
ATOM 2910  C CD  . PRO A 1 385 ? 44.080  -6.871  22.545  1.00 59.93  ? 379 PRO A CD  1 
ATOM 2911  N N   . LEU A 1 386 ? 42.239  -6.000  19.288  1.00 59.79  ? 380 LEU A N   1 
ATOM 2912  C CA  . LEU A 1 386 ? 41.431  -6.027  18.078  1.00 63.34  ? 380 LEU A CA  1 
ATOM 2913  C C   . LEU A 1 386 ? 40.267  -5.048  18.189  1.00 66.71  ? 380 LEU A C   1 
ATOM 2914  O O   . LEU A 1 386 ? 39.768  -4.589  17.167  1.00 72.03  ? 380 LEU A O   1 
ATOM 2915  C CB  . LEU A 1 386 ? 40.881  -7.431  17.815  1.00 65.53  ? 380 LEU A CB  1 
ATOM 2916  C CG  . LEU A 1 386 ? 41.820  -8.444  17.156  1.00 67.35  ? 380 LEU A CG  1 
ATOM 2917  C CD1 . LEU A 1 386 ? 43.095  -8.739  17.948  1.00 66.59  ? 380 LEU A CD1 1 
ATOM 2918  C CD2 . LEU A 1 386 ? 40.999  -9.707  16.926  1.00 70.44  ? 380 LEU A CD2 1 
ATOM 2919  N N   . VAL A 1 387 ? 39.783  -4.808  19.416  1.00 66.92  ? 381 VAL A N   1 
ATOM 2920  C CA  . VAL A 1 387 ? 38.634  -3.942  19.634  1.00 70.66  ? 381 VAL A CA  1 
ATOM 2921  C C   . VAL A 1 387 ? 39.087  -2.477  19.632  1.00 75.65  ? 381 VAL A C   1 
ATOM 2922  O O   . VAL A 1 387 ? 38.343  -1.606  19.180  1.00 68.50  ? 381 VAL A O   1 
ATOM 2923  C CB  . VAL A 1 387 ? 37.889  -4.324  20.933  1.00 66.92  ? 381 VAL A CB  1 
ATOM 2924  C CG1 . VAL A 1 387 ? 36.861  -3.284  21.366  1.00 58.14  ? 381 VAL A CG1 1 
ATOM 2925  C CG2 . VAL A 1 387 ? 37.220  -5.687  20.804  1.00 72.92  ? 381 VAL A CG2 1 
ATOM 2926  N N   . GLU A 1 388 ? 40.316  -2.210  20.109  1.00 78.00  ? 382 GLU A N   1 
ATOM 2927  C CA  . GLU A 1 388 ? 40.781  -0.846  20.343  1.00 74.41  ? 382 GLU A CA  1 
ATOM 2928  C C   . GLU A 1 388 ? 41.484  -0.262  19.110  1.00 67.07  ? 382 GLU A C   1 
ATOM 2929  O O   . GLU A 1 388 ? 41.478  0.958   18.911  1.00 54.40  ? 382 GLU A O   1 
ATOM 2930  C CB  . GLU A 1 388 ? 41.651  -0.838  21.598  1.00 76.72  ? 382 GLU A CB  1 
ATOM 2931  C CG  . GLU A 1 388 ? 43.013  -1.490  21.394  1.00 88.12  ? 382 GLU A CG  1 
ATOM 2932  C CD  . GLU A 1 388 ? 43.692  -1.956  22.670  1.00 99.90  ? 382 GLU A CD  1 
ATOM 2933  O OE1 . GLU A 1 388 ? 43.017  -2.044  23.728  1.00 93.43  ? 382 GLU A OE1 1 
ATOM 2934  O OE2 . GLU A 1 388 ? 44.915  -2.233  22.587  1.00 105.10 ? 382 GLU A OE2 1 
ATOM 2935  N N   . GLU A 1 389 ? 42.086  -1.131  18.286  1.00 60.86  ? 383 GLU A N   1 
ATOM 2936  C CA  . GLU A 1 389 ? 42.624  -0.713  17.003  1.00 61.27  ? 383 GLU A CA  1 
ATOM 2937  C C   . GLU A 1 389 ? 41.585  0.156   16.284  1.00 62.17  ? 383 GLU A C   1 
ATOM 2938  O O   . GLU A 1 389 ? 41.832  1.342   16.075  1.00 65.77  ? 383 GLU A O   1 
ATOM 2939  C CB  . GLU A 1 389 ? 43.156  -1.917  16.218  1.00 63.54  ? 383 GLU A CB  1 
ATOM 2940  C CG  . GLU A 1 389 ? 43.913  -1.556  14.939  1.00 70.47  ? 383 GLU A CG  1 
ATOM 2941  C CD  . GLU A 1 389 ? 43.165  -1.621  13.611  1.00 76.92  ? 383 GLU A CD  1 
ATOM 2942  O OE1 . GLU A 1 389 ? 42.155  -2.359  13.549  1.00 79.19  ? 383 GLU A OE1 1 
ATOM 2943  O OE2 . GLU A 1 389 ? 43.578  -0.931  12.635  1.00 78.08  ? 383 GLU A OE2 1 
ATOM 2944  N N   . PRO A 1 390 ? 40.386  -0.357  15.906  1.00 57.64  ? 384 PRO A N   1 
ATOM 2945  C CA  . PRO A 1 390 ? 39.421  0.430   15.135  1.00 56.59  ? 384 PRO A CA  1 
ATOM 2946  C C   . PRO A 1 390 ? 38.826  1.614   15.884  1.00 60.87  ? 384 PRO A C   1 
ATOM 2947  O O   . PRO A 1 390 ? 38.523  2.641   15.274  1.00 61.24  ? 384 PRO A O   1 
ATOM 2948  C CB  . PRO A 1 390 ? 38.337  -0.594  14.745  1.00 53.09  ? 384 PRO A CB  1 
ATOM 2949  C CG  . PRO A 1 390 ? 38.414  -1.631  15.809  1.00 52.80  ? 384 PRO A CG  1 
ATOM 2950  C CD  . PRO A 1 390 ? 39.892  -1.713  16.162  1.00 56.12  ? 384 PRO A CD  1 
ATOM 2951  N N   . GLN A 1 391 ? 38.668  1.465   17.206  1.00 67.80  ? 385 GLN A N   1 
ATOM 2952  C CA  . GLN A 1 391 ? 38.021  2.489   18.018  1.00 71.37  ? 385 GLN A CA  1 
ATOM 2953  C C   . GLN A 1 391 ? 38.879  3.752   18.110  1.00 61.95  ? 385 GLN A C   1 
ATOM 2954  O O   . GLN A 1 391 ? 38.383  4.855   17.884  1.00 55.22  ? 385 GLN A O   1 
ATOM 2955  C CB  . GLN A 1 391 ? 37.742  1.967   19.424  1.00 76.67  ? 385 GLN A CB  1 
ATOM 2956  C CG  . GLN A 1 391 ? 36.556  1.017   19.513  1.00 77.65  ? 385 GLN A CG  1 
ATOM 2957  C CD  . GLN A 1 391 ? 36.332  0.525   20.925  1.00 81.33  ? 385 GLN A CD  1 
ATOM 2958  O OE1 . GLN A 1 391 ? 37.281  0.288   21.686  1.00 71.75  ? 385 GLN A OE1 1 
ATOM 2959  N NE2 . GLN A 1 391 ? 35.064  0.403   21.295  1.00 87.16  ? 385 GLN A NE2 1 
ATOM 2960  N N   . ASN A 1 392 ? 40.158  3.572   18.460  1.00 57.35  ? 386 ASN A N   1 
ATOM 2961  C CA  . ASN A 1 392 ? 41.100  4.673   18.570  1.00 59.89  ? 386 ASN A CA  1 
ATOM 2962  C C   . ASN A 1 392 ? 41.359  5.273   17.186  1.00 60.47  ? 386 ASN A C   1 
ATOM 2963  O O   . ASN A 1 392 ? 41.541  6.482   17.036  1.00 57.22  ? 386 ASN A O   1 
ATOM 2964  C CB  . ASN A 1 392 ? 42.366  4.201   19.272  1.00 64.04  ? 386 ASN A CB  1 
ATOM 2965  C CG  . ASN A 1 392 ? 42.091  3.748   20.690  1.00 72.21  ? 386 ASN A CG  1 
ATOM 2966  O OD1 . ASN A 1 392 ? 40.974  3.911   21.202  1.00 64.76  ? 386 ASN A OD1 1 
ATOM 2967  N ND2 . ASN A 1 392 ? 43.095  3.185   21.349  1.00 82.39  ? 386 ASN A ND2 1 
ATOM 2968  N N   . LEU A 1 393 ? 41.359  4.408   16.170  1.00 61.76  ? 387 LEU A N   1 
ATOM 2969  C CA  . LEU A 1 393 ? 41.446  4.848   14.794  1.00 60.40  ? 387 LEU A CA  1 
ATOM 2970  C C   . LEU A 1 393 ? 40.282  5.779   14.500  1.00 61.01  ? 387 LEU A C   1 
ATOM 2971  O O   . LEU A 1 393 ? 40.523  6.891   14.047  1.00 77.24  ? 387 LEU A O   1 
ATOM 2972  C CB  . LEU A 1 393 ? 41.438  3.670   13.831  1.00 66.61  ? 387 LEU A CB  1 
ATOM 2973  C CG  . LEU A 1 393 ? 42.225  3.888   12.540  1.00 71.33  ? 387 LEU A CG  1 
ATOM 2974  C CD1 . LEU A 1 393 ? 43.722  3.678   12.802  1.00 67.62  ? 387 LEU A CD1 1 
ATOM 2975  C CD2 . LEU A 1 393 ? 41.692  2.971   11.452  1.00 76.18  ? 387 LEU A CD2 1 
ATOM 2976  N N   . ILE A 1 394 ? 39.043  5.338   14.778  1.00 56.56  ? 388 ILE A N   1 
ATOM 2977  C CA  . ILE A 1 394 ? 37.865  6.166   14.532  1.00 58.10  ? 388 ILE A CA  1 
ATOM 2978  C C   . ILE A 1 394 ? 37.980  7.513   15.261  1.00 63.59  ? 388 ILE A C   1 
ATOM 2979  O O   . ILE A 1 394 ? 37.612  8.557   14.704  1.00 59.37  ? 388 ILE A O   1 
ATOM 2980  C CB  . ILE A 1 394 ? 36.553  5.440   14.891  1.00 52.71  ? 388 ILE A CB  1 
ATOM 2981  C CG1 . ILE A 1 394 ? 36.190  4.406   13.847  1.00 52.56  ? 388 ILE A CG1 1 
ATOM 2982  C CG2 . ILE A 1 394 ? 35.409  6.444   15.070  1.00 53.04  ? 388 ILE A CG2 1 
ATOM 2983  C CD1 . ILE A 1 394 ? 34.891  3.664   14.122  1.00 54.27  ? 388 ILE A CD1 1 
ATOM 2984  N N   . LYS A 1 395 ? 38.485  7.494   16.504  1.00 63.92  ? 389 LYS A N   1 
ATOM 2985  C CA  . LYS A 1 395 ? 38.536  8.704   17.310  1.00 73.02  ? 389 LYS A CA  1 
ATOM 2986  C C   . LYS A 1 395 ? 39.528  9.703   16.704  1.00 72.42  ? 389 LYS A C   1 
ATOM 2987  O O   . LYS A 1 395 ? 39.143  10.840  16.414  1.00 71.20  ? 389 LYS A O   1 
ATOM 2988  C CB  . LYS A 1 395 ? 38.729  8.394   18.803  1.00 83.93  ? 389 LYS A CB  1 
ATOM 2989  C CG  . LYS A 1 395 ? 37.489  8.686   19.664  1.00 92.51  ? 389 LYS A CG  1 
ATOM 2990  C CD  . LYS A 1 395 ? 37.199  10.186  19.764  1.00 99.24  ? 389 LYS A CD  1 
ATOM 2991  C CE  . LYS A 1 395 ? 35.760  10.592  19.607  1.00 96.82  ? 389 LYS A CE  1 
ATOM 2992  N NZ  . LYS A 1 395 ? 35.635  11.958  19.083  1.00 90.86  ? 389 LYS A NZ  1 
ATOM 2993  N N   . GLN A 1 396 ? 40.782  9.274   16.483  1.00 67.90  ? 390 GLN A N   1 
ATOM 2994  C CA  . GLN A 1 396 ? 41.800  10.150  15.916  1.00 67.25  ? 390 GLN A CA  1 
ATOM 2995  C C   . GLN A 1 396 ? 41.218  10.900  14.713  1.00 59.50  ? 390 GLN A C   1 
ATOM 2996  O O   . GLN A 1 396 ? 41.368  12.116  14.578  1.00 53.14  ? 390 GLN A O   1 
ATOM 2997  C CB  . GLN A 1 396 ? 43.062  9.358   15.566  1.00 72.58  ? 390 GLN A CB  1 
ATOM 2998  C CG  . GLN A 1 396 ? 43.859  8.883   16.778  1.00 81.30  ? 390 GLN A CG  1 
ATOM 2999  C CD  . GLN A 1 396 ? 45.011  7.966   16.414  1.00 94.41  ? 390 GLN A CD  1 
ATOM 3000  O OE1 . GLN A 1 396 ? 45.699  8.176   15.408  1.00 95.44  ? 390 GLN A OE1 1 
ATOM 3001  N NE2 . GLN A 1 396 ? 45.229  6.927   17.213  1.00 97.38  ? 390 GLN A NE2 1 
ATOM 3002  N N   . ASN A 1 397 ? 40.494  10.168  13.868  1.00 55.32  ? 391 ASN A N   1 
ATOM 3003  C CA  . ASN A 1 397 ? 39.996  10.725  12.627  1.00 58.24  ? 391 ASN A CA  1 
ATOM 3004  C C   . ASN A 1 397 ? 38.739  11.548  12.840  1.00 55.26  ? 391 ASN A C   1 
ATOM 3005  O O   . ASN A 1 397 ? 38.435  12.396  12.015  1.00 60.54  ? 391 ASN A O   1 
ATOM 3006  C CB  . ASN A 1 397 ? 39.713  9.656   11.582  1.00 58.40  ? 391 ASN A CB  1 
ATOM 3007  C CG  . ASN A 1 397 ? 41.005  9.193   10.970  1.00 56.21  ? 391 ASN A CG  1 
ATOM 3008  O OD1 . ASN A 1 397 ? 41.517  9.812   10.029  1.00 58.71  ? 391 ASN A OD1 1 
ATOM 3009  N ND2 . ASN A 1 397 ? 41.561  8.136   11.532  1.00 53.72  ? 391 ASN A ND2 1 
ATOM 3010  N N   . CYS A 1 398 ? 37.975  11.276  13.889  1.00 52.96  ? 392 CYS A N   1 
ATOM 3011  C CA  . CYS A 1 398 ? 36.816  12.113  14.121  1.00 60.58  ? 392 CYS A CA  1 
ATOM 3012  C C   . CYS A 1 398 ? 37.229  13.425  14.777  1.00 64.62  ? 392 CYS A C   1 
ATOM 3013  O O   . CYS A 1 398 ? 36.618  14.458  14.529  1.00 56.56  ? 392 CYS A O   1 
ATOM 3014  C CB  . CYS A 1 398 ? 35.769  11.357  14.911  1.00 68.96  ? 392 CYS A CB  1 
ATOM 3015  S SG  . CYS A 1 398 ? 34.863  10.227  13.835  1.00 77.69  ? 392 CYS A SG  1 
ATOM 3016  N N   . GLU A 1 399 ? 38.259  13.366  15.625  1.00 72.88  ? 393 GLU A N   1 
ATOM 3017  C CA  . GLU A 1 399 ? 38.834  14.571  16.193  1.00 74.35  ? 393 GLU A CA  1 
ATOM 3018  C C   . GLU A 1 399 ? 39.310  15.480  15.066  1.00 76.56  ? 393 GLU A C   1 
ATOM 3019  O O   . GLU A 1 399 ? 38.952  16.663  15.038  1.00 79.12  ? 393 GLU A O   1 
ATOM 3020  C CB  . GLU A 1 399 ? 39.996  14.244  17.126  1.00 73.57  ? 393 GLU A CB  1 
ATOM 3021  C CG  . GLU A 1 399 ? 39.525  13.810  18.509  1.00 77.06  ? 393 GLU A CG  1 
ATOM 3022  C CD  . GLU A 1 399 ? 40.649  13.710  19.522  1.00 79.12  ? 393 GLU A CD  1 
ATOM 3023  O OE1 . GLU A 1 399 ? 41.833  13.824  19.114  1.00 65.89  ? 393 GLU A OE1 1 
ATOM 3024  O OE2 . GLU A 1 399 ? 40.326  13.527  20.720  1.00 81.60  ? 393 GLU A OE2 1 
ATOM 3025  N N   . LEU A 1 400 ? 40.092  14.892  14.143  1.00 70.93  ? 394 LEU A N   1 
ATOM 3026  C CA  . LEU A 1 400 ? 40.747  15.641  13.079  1.00 61.90  ? 394 LEU A CA  1 
ATOM 3027  C C   . LEU A 1 400 ? 39.708  16.246  12.134  1.00 55.96  ? 394 LEU A C   1 
ATOM 3028  O O   . LEU A 1 400 ? 39.872  17.378  11.704  1.00 50.55  ? 394 LEU A O   1 
ATOM 3029  C CB  . LEU A 1 400 ? 41.751  14.780  12.319  1.00 59.62  ? 394 LEU A CB  1 
ATOM 3030  C CG  . LEU A 1 400 ? 42.932  15.551  11.729  1.00 66.54  ? 394 LEU A CG  1 
ATOM 3031  C CD1 . LEU A 1 400 ? 43.805  16.158  12.834  1.00 66.87  ? 394 LEU A CD1 1 
ATOM 3032  C CD2 . LEU A 1 400 ? 43.752  14.656  10.798  1.00 69.02  ? 394 LEU A CD2 1 
ATOM 3033  N N   . PHE A 1 401 ? 38.631  15.502  11.850  1.00 56.46  ? 395 PHE A N   1 
ATOM 3034  C CA  . PHE A 1 401 ? 37.529  15.968  11.020  1.00 53.98  ? 395 PHE A CA  1 
ATOM 3035  C C   . PHE A 1 401 ? 36.820  17.153  11.659  1.00 56.93  ? 395 PHE A C   1 
ATOM 3036  O O   . PHE A 1 401 ? 36.342  18.028  10.936  1.00 53.11  ? 395 PHE A O   1 
ATOM 3037  C CB  . PHE A 1 401 ? 36.460  14.891  10.814  1.00 53.89  ? 395 PHE A CB  1 
ATOM 3038  C CG  . PHE A 1 401 ? 35.186  15.386  10.138  1.00 54.14  ? 395 PHE A CG  1 
ATOM 3039  C CD1 . PHE A 1 401 ? 34.175  15.989  10.875  1.00 54.45  ? 395 PHE A CD1 1 
ATOM 3040  C CD2 . PHE A 1 401 ? 34.992  15.239  8.768   1.00 55.98  ? 395 PHE A CD2 1 
ATOM 3041  C CE1 . PHE A 1 401 ? 33.014  16.438  10.267  1.00 50.96  ? 395 PHE A CE1 1 
ATOM 3042  C CE2 . PHE A 1 401 ? 33.828  15.689  8.166   1.00 51.70  ? 395 PHE A CE2 1 
ATOM 3043  C CZ  . PHE A 1 401 ? 32.842  16.282  8.920   1.00 51.40  ? 395 PHE A CZ  1 
ATOM 3044  N N   . GLU A 1 402 ? 36.731  17.129  13.001  1.00 71.41  ? 396 GLU A N   1 
ATOM 3045  C CA  . GLU A 1 402 ? 35.930  18.075  13.766  1.00 81.94  ? 396 GLU A CA  1 
ATOM 3046  C C   . GLU A 1 402 ? 36.654  19.418  13.871  1.00 82.05  ? 396 GLU A C   1 
ATOM 3047  O O   . GLU A 1 402 ? 35.990  20.455  13.887  1.00 85.81  ? 396 GLU A O   1 
ATOM 3048  C CB  . GLU A 1 402 ? 35.548  17.520  15.144  1.00 90.17  ? 396 GLU A CB  1 
ATOM 3049  C CG  . GLU A 1 402 ? 34.441  18.302  15.855  1.00 94.90  ? 396 GLU A CG  1 
ATOM 3050  C CD  . GLU A 1 402 ? 33.106  18.481  15.134  1.00 98.06  ? 396 GLU A CD  1 
ATOM 3051  O OE1 . GLU A 1 402 ? 32.836  17.869  14.068  1.00 91.54  ? 396 GLU A OE1 1 
ATOM 3052  O OE2 . GLU A 1 402 ? 32.314  19.282  15.680  1.00 91.78  ? 396 GLU A OE2 1 
ATOM 3053  N N   . GLN A 1 403 ? 37.997  19.403  13.925  1.00 72.53  ? 397 GLN A N   1 
ATOM 3054  C CA  . GLN A 1 403 ? 38.764  20.644  13.886  1.00 76.23  ? 397 GLN A CA  1 
ATOM 3055  C C   . GLN A 1 403 ? 38.878  21.186  12.452  1.00 78.22  ? 397 GLN A C   1 
ATOM 3056  O O   . GLN A 1 403 ? 38.722  22.389  12.255  1.00 99.03  ? 397 GLN A O   1 
ATOM 3057  C CB  . GLN A 1 403 ? 40.106  20.544  14.620  1.00 76.57  ? 397 GLN A CB  1 
ATOM 3058  C CG  . GLN A 1 403 ? 41.044  19.456  14.107  1.00 81.69  ? 397 GLN A CG  1 
ATOM 3059  C CD  . GLN A 1 403 ? 42.105  19.017  15.101  1.00 83.76  ? 397 GLN A CD  1 
ATOM 3060  O OE1 . GLN A 1 403 ? 41.819  18.407  16.138  1.00 65.01  ? 397 GLN A OE1 1 
ATOM 3061  N NE2 . GLN A 1 403 ? 43.364  19.272  14.769  1.00 97.13  ? 397 GLN A NE2 1 
ATOM 3062  N N   . LEU A 1 404 ? 39.100  20.324  11.442  1.00 66.97  ? 398 LEU A N   1 
ATOM 3063  C CA  . LEU A 1 404 ? 39.433  20.784  10.096  1.00 56.84  ? 398 LEU A CA  1 
ATOM 3064  C C   . LEU A 1 404 ? 38.190  20.961  9.223   1.00 52.75  ? 398 LEU A C   1 
ATOM 3065  O O   . LEU A 1 404 ? 38.207  21.777  8.302   1.00 49.84  ? 398 LEU A O   1 
ATOM 3066  C CB  . LEU A 1 404 ? 40.413  19.856  9.381   1.00 55.01  ? 398 LEU A CB  1 
ATOM 3067  C CG  . LEU A 1 404 ? 41.781  19.625  10.031  1.00 55.41  ? 398 LEU A CG  1 
ATOM 3068  C CD1 . LEU A 1 404 ? 42.665  18.876  9.044   1.00 58.47  ? 398 LEU A CD1 1 
ATOM 3069  C CD2 . LEU A 1 404 ? 42.468  20.885  10.499  1.00 55.42  ? 398 LEU A CD2 1 
ATOM 3070  N N   . GLY A 1 405 ? 37.149  20.152  9.442   1.00 49.33  ? 399 GLY A N   1 
ATOM 3071  C CA  . GLY A 1 405 ? 36.001  20.161  8.547   1.00 54.83  ? 399 GLY A CA  1 
ATOM 3072  C C   . GLY A 1 405 ? 36.260  19.401  7.237   1.00 56.78  ? 399 GLY A C   1 
ATOM 3073  O O   . GLY A 1 405 ? 37.379  18.985  6.944   1.00 44.63  ? 399 GLY A O   1 
ATOM 3074  N N   . GLU A 1 406 ? 35.196  19.253  6.428   1.00 66.15  ? 400 GLU A N   1 
ATOM 3075  C CA  . GLU A 1 406 ? 35.186  18.353  5.280   1.00 70.66  ? 400 GLU A CA  1 
ATOM 3076  C C   . GLU A 1 406 ? 36.398  18.620  4.382   1.00 70.45  ? 400 GLU A C   1 
ATOM 3077  O O   . GLU A 1 406 ? 37.271  17.765  4.275   1.00 76.51  ? 400 GLU A O   1 
ATOM 3078  C CB  . GLU A 1 406 ? 33.845  18.368  4.530   1.00 68.20  ? 400 GLU A CB  1 
ATOM 3079  C CG  . GLU A 1 406 ? 33.748  17.320  3.421   1.00 69.86  ? 400 GLU A CG  1 
ATOM 3080  C CD  . GLU A 1 406 ? 32.347  16.906  2.971   1.00 80.53  ? 400 GLU A CD  1 
ATOM 3081  O OE1 . GLU A 1 406 ? 31.522  16.494  3.824   1.00 80.87  ? 400 GLU A OE1 1 
ATOM 3082  O OE2 . GLU A 1 406 ? 32.082  16.949  1.744   1.00 88.08  ? 400 GLU A OE2 1 
ATOM 3083  N N   . TYR A 1 407 ? 36.471  19.800  3.756   1.00 62.98  ? 401 TYR A N   1 
ATOM 3084  C CA  . TYR A 1 407 ? 37.489  20.048  2.747   1.00 64.10  ? 401 TYR A CA  1 
ATOM 3085  C C   . TYR A 1 407 ? 38.888  19.894  3.355   1.00 61.72  ? 401 TYR A C   1 
ATOM 3086  O O   . TYR A 1 407 ? 39.681  19.099  2.869   1.00 65.04  ? 401 TYR A O   1 
ATOM 3087  C CB  . TYR A 1 407 ? 37.240  21.404  2.074   1.00 68.97  ? 401 TYR A CB  1 
ATOM 3088  C CG  . TYR A 1 407 ? 38.417  22.034  1.325   1.00 72.24  ? 401 TYR A CG  1 
ATOM 3089  C CD1 . TYR A 1 407 ? 38.705  21.708  0.002   1.00 78.97  ? 401 TYR A CD1 1 
ATOM 3090  C CD2 . TYR A 1 407 ? 39.226  22.990  1.931   1.00 72.93  ? 401 TYR A CD2 1 
ATOM 3091  C CE1 . TYR A 1 407 ? 39.764  22.291  -0.683  1.00 81.61  ? 401 TYR A CE1 1 
ATOM 3092  C CE2 . TYR A 1 407 ? 40.284  23.584  1.258   1.00 84.95  ? 401 TYR A CE2 1 
ATOM 3093  C CZ  . TYR A 1 407 ? 40.557  23.240  -0.057  1.00 86.68  ? 401 TYR A CZ  1 
ATOM 3094  O OH  . TYR A 1 407 ? 41.610  23.835  -0.706  1.00 76.08  ? 401 TYR A OH  1 
ATOM 3095  N N   . LYS A 1 408 ? 39.204  20.645  4.414   1.00 60.20  ? 402 LYS A N   1 
ATOM 3096  C CA  . LYS A 1 408 ? 40.556  20.666  4.955   1.00 62.20  ? 402 LYS A CA  1 
ATOM 3097  C C   . LYS A 1 408 ? 40.974  19.260  5.389   1.00 63.07  ? 402 LYS A C   1 
ATOM 3098  O O   . LYS A 1 408 ? 42.148  18.901  5.297   1.00 60.81  ? 402 LYS A O   1 
ATOM 3099  C CB  . LYS A 1 408 ? 40.663  21.672  6.110   1.00 68.54  ? 402 LYS A CB  1 
ATOM 3100  C CG  . LYS A 1 408 ? 41.052  23.104  5.733   1.00 75.80  ? 402 LYS A CG  1 
ATOM 3101  C CD  . LYS A 1 408 ? 40.881  24.150  6.842   1.00 83.24  ? 402 LYS A CD  1 
ATOM 3102  C CE  . LYS A 1 408 ? 41.745  24.015  8.078   1.00 82.41  ? 402 LYS A CE  1 
ATOM 3103  N NZ  . LYS A 1 408 ? 43.108  24.537  7.916   1.00 81.32  ? 402 LYS A NZ  1 
ATOM 3104  N N   . PHE A 1 409 ? 39.999  18.482  5.879   1.00 65.97  ? 403 PHE A N   1 
ATOM 3105  C CA  . PHE A 1 409 ? 40.205  17.098  6.286   1.00 67.66  ? 403 PHE A CA  1 
ATOM 3106  C C   . PHE A 1 409 ? 40.539  16.221  5.078   1.00 63.25  ? 403 PHE A C   1 
ATOM 3107  O O   . PHE A 1 409 ? 41.430  15.374  5.142   1.00 59.26  ? 403 PHE A O   1 
ATOM 3108  C CB  . PHE A 1 409 ? 38.934  16.576  6.968   1.00 71.26  ? 403 PHE A CB  1 
ATOM 3109  C CG  . PHE A 1 409 ? 38.979  15.128  7.444   1.00 69.05  ? 403 PHE A CG  1 
ATOM 3110  C CD1 . PHE A 1 409 ? 40.022  14.685  8.247   1.00 68.47  ? 403 PHE A CD1 1 
ATOM 3111  C CD2 . PHE A 1 409 ? 37.985  14.220  7.077   1.00 65.87  ? 403 PHE A CD2 1 
ATOM 3112  C CE1 . PHE A 1 409 ? 40.066  13.372  8.678   1.00 74.11  ? 403 PHE A CE1 1 
ATOM 3113  C CE2 . PHE A 1 409 ? 38.029  12.911  7.515   1.00 64.56  ? 403 PHE A CE2 1 
ATOM 3114  C CZ  . PHE A 1 409 ? 39.071  12.489  8.311   1.00 71.11  ? 403 PHE A CZ  1 
ATOM 3115  N N   . GLN A 1 410 ? 39.783  16.411  3.990   1.00 56.73  ? 404 GLN A N   1 
ATOM 3116  C CA  . GLN A 1 410 ? 40.091  15.789  2.716   1.00 53.45  ? 404 GLN A CA  1 
ATOM 3117  C C   . GLN A 1 410 ? 41.565  16.024  2.393   1.00 55.64  ? 404 GLN A C   1 
ATOM 3118  O O   . GLN A 1 410 ? 42.262  15.094  2.004   1.00 60.66  ? 404 GLN A O   1 
ATOM 3119  C CB  . GLN A 1 410 ? 39.151  16.324  1.636   1.00 51.00  ? 404 GLN A CB  1 
ATOM 3120  C CG  . GLN A 1 410 ? 37.711  15.858  1.820   1.00 55.76  ? 404 GLN A CG  1 
ATOM 3121  C CD  . GLN A 1 410 ? 36.740  16.411  0.800   1.00 59.92  ? 404 GLN A CD  1 
ATOM 3122  O OE1 . GLN A 1 410 ? 37.087  17.259  -0.025  1.00 69.90  ? 404 GLN A OE1 1 
ATOM 3123  N NE2 . GLN A 1 410 ? 35.501  15.944  0.849   1.00 59.10  ? 404 GLN A NE2 1 
ATOM 3124  N N   . ASN A 1 411 ? 42.043  17.253  2.620   1.00 53.98  ? 405 ASN A N   1 
ATOM 3125  C CA  . ASN A 1 411 ? 43.406  17.635  2.283   1.00 53.87  ? 405 ASN A CA  1 
ATOM 3126  C C   . ASN A 1 411 ? 44.393  16.879  3.172   1.00 54.37  ? 405 ASN A C   1 
ATOM 3127  O O   . ASN A 1 411 ? 45.418  16.410  2.687   1.00 61.81  ? 405 ASN A O   1 
ATOM 3128  C CB  . ASN A 1 411 ? 43.593  19.152  2.330   1.00 52.10  ? 405 ASN A CB  1 
ATOM 3129  C CG  . ASN A 1 411 ? 42.680  19.905  1.379   1.00 52.30  ? 405 ASN A CG  1 
ATOM 3130  O OD1 . ASN A 1 411 ? 42.063  19.331  0.471   1.00 45.38  ? 405 ASN A OD1 1 
ATOM 3131  N ND2 . ASN A 1 411 ? 42.585  21.214  1.554   1.00 55.55  ? 405 ASN A ND2 1 
ATOM 3132  N N   . ALA A 1 412 ? 44.085  16.737  4.464   1.00 52.33  ? 406 ALA A N   1 
ATOM 3133  C CA  . ALA A 1 412 ? 44.989  16.047  5.368   1.00 55.68  ? 406 ALA A CA  1 
ATOM 3134  C C   . ALA A 1 412 ? 45.082  14.561  5.018   1.00 53.14  ? 406 ALA A C   1 
ATOM 3135  O O   . ALA A 1 412 ? 46.089  13.932  5.343   1.00 54.60  ? 406 ALA A O   1 
ATOM 3136  C CB  . ALA A 1 412 ? 44.553  16.254  6.798   1.00 62.62  ? 406 ALA A CB  1 
ATOM 3137  N N   . LEU A 1 413 ? 44.037  14.022  4.362   1.00 53.29  ? 407 LEU A N   1 
ATOM 3138  C CA  . LEU A 1 413 ? 43.999  12.643  3.868   1.00 55.66  ? 407 LEU A CA  1 
ATOM 3139  C C   . LEU A 1 413 ? 44.781  12.504  2.559   1.00 56.76  ? 407 LEU A C   1 
ATOM 3140  O O   . LEU A 1 413 ? 45.383  11.463  2.322   1.00 59.48  ? 407 LEU A O   1 
ATOM 3141  C CB  . LEU A 1 413 ? 42.572  12.138  3.625   1.00 57.28  ? 407 LEU A CB  1 
ATOM 3142  C CG  . LEU A 1 413 ? 41.664  11.911  4.840   1.00 56.51  ? 407 LEU A CG  1 
ATOM 3143  C CD1 . LEU A 1 413 ? 40.166  11.801  4.474   1.00 52.09  ? 407 LEU A CD1 1 
ATOM 3144  C CD2 . LEU A 1 413 ? 42.162  10.663  5.565   1.00 56.15  ? 407 LEU A CD2 1 
ATOM 3145  N N   . LEU A 1 414 ? 44.713  13.507  1.673   1.00 55.95  ? 408 LEU A N   1 
ATOM 3146  C CA  . LEU A 1 414 ? 45.445  13.438  0.422   1.00 56.57  ? 408 LEU A CA  1 
ATOM 3147  C C   . LEU A 1 414 ? 46.935  13.334  0.714   1.00 57.57  ? 408 LEU A C   1 
ATOM 3148  O O   . LEU A 1 414 ? 47.640  12.656  -0.010  1.00 59.04  ? 408 LEU A O   1 
ATOM 3149  C CB  . LEU A 1 414 ? 45.196  14.614  -0.508  1.00 62.70  ? 408 LEU A CB  1 
ATOM 3150  C CG  . LEU A 1 414 ? 43.947  14.513  -1.377  1.00 76.19  ? 408 LEU A CG  1 
ATOM 3151  C CD1 . LEU A 1 414 ? 42.743  14.822  -0.552  1.00 82.16  ? 408 LEU A CD1 1 
ATOM 3152  C CD2 . LEU A 1 414 ? 44.010  15.475  -2.534  1.00 92.03  ? 408 LEU A CD2 1 
ATOM 3153  N N   . VAL A 1 415 ? 47.424  14.023  1.745   1.00 58.88  ? 409 VAL A N   1 
ATOM 3154  C CA  . VAL A 1 415 ? 48.841  13.949  2.060   1.00 63.93  ? 409 VAL A CA  1 
ATOM 3155  C C   . VAL A 1 415 ? 49.167  12.572  2.642   1.00 69.84  ? 409 VAL A C   1 
ATOM 3156  O O   . VAL A 1 415 ? 50.199  11.991  2.305   1.00 67.59  ? 409 VAL A O   1 
ATOM 3157  C CB  . VAL A 1 415 ? 49.269  15.076  3.013   1.00 63.97  ? 409 VAL A CB  1 
ATOM 3158  C CG1 . VAL A 1 415 ? 50.746  14.971  3.393   1.00 62.54  ? 409 VAL A CG1 1 
ATOM 3159  C CG2 . VAL A 1 415 ? 48.955  16.442  2.418   1.00 65.00  ? 409 VAL A CG2 1 
ATOM 3160  N N   . ARG A 1 416 ? 48.292  12.071  3.528   1.00 74.94  ? 410 ARG A N   1 
ATOM 3161  C CA  . ARG A 1 416 ? 48.465  10.770  4.167   1.00 76.25  ? 410 ARG A CA  1 
ATOM 3162  C C   . ARG A 1 416 ? 48.664  9.700   3.095   1.00 66.61  ? 410 ARG A C   1 
ATOM 3163  O O   . ARG A 1 416 ? 49.714  9.073   3.033   1.00 71.35  ? 410 ARG A O   1 
ATOM 3164  C CB  . ARG A 1 416 ? 47.275  10.455  5.091   1.00 81.66  ? 410 ARG A CB  1 
ATOM 3165  C CG  . ARG A 1 416 ? 47.197  9.061   5.712   1.00 80.08  ? 410 ARG A CG  1 
ATOM 3166  C CD  . ARG A 1 416 ? 45.955  8.840   6.595   1.00 72.34  ? 410 ARG A CD  1 
ATOM 3167  N NE  . ARG A 1 416 ? 46.042  9.613   7.839   1.00 72.34  ? 410 ARG A NE  1 
ATOM 3168  C CZ  . ARG A 1 416 ? 45.061  9.859   8.711   1.00 70.17  ? 410 ARG A CZ  1 
ATOM 3169  N NH1 . ARG A 1 416 ? 43.812  9.499   8.467   1.00 63.50  ? 410 ARG A NH1 1 
ATOM 3170  N NH2 . ARG A 1 416 ? 45.337  10.510  9.830   1.00 70.36  ? 410 ARG A NH2 1 
ATOM 3171  N N   . TYR A 1 417 ? 47.670  9.541   2.222   1.00 57.31  ? 411 TYR A N   1 
ATOM 3172  C CA  . TYR A 1 417 ? 47.605  8.388   1.349   1.00 61.31  ? 411 TYR A CA  1 
ATOM 3173  C C   . TYR A 1 417 ? 48.548  8.500   0.155   1.00 62.11  ? 411 TYR A C   1 
ATOM 3174  O O   . TYR A 1 417 ? 48.945  7.473   -0.378  1.00 65.35  ? 411 TYR A O   1 
ATOM 3175  C CB  . TYR A 1 417 ? 46.136  8.220   0.958   1.00 65.38  ? 411 TYR A CB  1 
ATOM 3176  C CG  . TYR A 1 417 ? 45.269  7.750   2.116   1.00 70.72  ? 411 TYR A CG  1 
ATOM 3177  C CD1 . TYR A 1 417 ? 45.777  6.863   3.064   1.00 73.31  ? 411 TYR A CD1 1 
ATOM 3178  C CD2 . TYR A 1 417 ? 43.949  8.181   2.258   1.00 70.07  ? 411 TYR A CD2 1 
ATOM 3179  C CE1 . TYR A 1 417 ? 45.001  6.422   4.121   1.00 79.15  ? 411 TYR A CE1 1 
ATOM 3180  C CE2 . TYR A 1 417 ? 43.163  7.739   3.311   1.00 72.96  ? 411 TYR A CE2 1 
ATOM 3181  C CZ  . TYR A 1 417 ? 43.694  6.858   4.242   1.00 79.81  ? 411 TYR A CZ  1 
ATOM 3182  O OH  . TYR A 1 417 ? 42.984  6.384   5.302   1.00 92.40  ? 411 TYR A OH  1 
ATOM 3183  N N   . THR A 1 418 ? 48.922  9.713   -0.267  1.00 66.30  ? 412 THR A N   1 
ATOM 3184  C CA  . THR A 1 418 ? 49.852  9.838   -1.382  1.00 68.64  ? 412 THR A CA  1 
ATOM 3185  C C   . THR A 1 418 ? 51.268  9.600   -0.857  1.00 66.44  ? 412 THR A C   1 
ATOM 3186  O O   . THR A 1 418 ? 52.135  9.213   -1.633  1.00 67.40  ? 412 THR A O   1 
ATOM 3187  C CB  . THR A 1 418 ? 49.762  11.166  -2.150  1.00 72.47  ? 412 THR A CB  1 
ATOM 3188  O OG1 . THR A 1 418 ? 50.674  12.102  -1.578  1.00 77.94  ? 412 THR A OG1 1 
ATOM 3189  C CG2 . THR A 1 418 ? 48.363  11.758  -2.220  1.00 67.06  ? 412 THR A CG2 1 
ATOM 3190  N N   . LYS A 1 419 ? 51.498  9.834   0.447   1.00 66.33  ? 413 LYS A N   1 
ATOM 3191  C CA  . LYS A 1 419 ? 52.766  9.484   1.079   1.00 70.84  ? 413 LYS A CA  1 
ATOM 3192  C C   . LYS A 1 419 ? 52.877  7.966   1.197   1.00 66.70  ? 413 LYS A C   1 
ATOM 3193  O O   . LYS A 1 419 ? 53.984  7.429   1.163   1.00 57.84  ? 413 LYS A O   1 
ATOM 3194  C CB  . LYS A 1 419 ? 52.979  10.163  2.441   1.00 72.58  ? 413 LYS A CB  1 
ATOM 3195  C CG  . LYS A 1 419 ? 53.616  11.537  2.315   1.00 79.11  ? 413 LYS A CG  1 
ATOM 3196  C CD  . LYS A 1 419 ? 53.869  12.321  3.595   1.00 84.48  ? 413 LYS A CD  1 
ATOM 3197  C CE  . LYS A 1 419 ? 54.361  13.692  3.222   1.00 96.64  ? 413 LYS A CE  1 
ATOM 3198  N NZ  . LYS A 1 419 ? 54.695  14.546  4.366   1.00 107.75 ? 413 LYS A NZ  1 
ATOM 3199  N N   . LYS A 1 420 ? 51.717  7.300   1.307   1.00 68.63  ? 414 LYS A N   1 
ATOM 3200  C CA  . LYS A 1 420 ? 51.652  5.869   1.552   1.00 74.57  ? 414 LYS A CA  1 
ATOM 3201  C C   . LYS A 1 420 ? 51.816  5.116   0.242   1.00 79.55  ? 414 LYS A C   1 
ATOM 3202  O O   . LYS A 1 420 ? 52.680  4.246   0.170   1.00 86.25  ? 414 LYS A O   1 
ATOM 3203  C CB  . LYS A 1 420 ? 50.366  5.427   2.263   1.00 83.36  ? 414 LYS A CB  1 
ATOM 3204  C CG  . LYS A 1 420 ? 50.345  5.719   3.772   1.00 86.51  ? 414 LYS A CG  1 
ATOM 3205  C CD  . LYS A 1 420 ? 49.245  5.054   4.594   1.00 82.68  ? 414 LYS A CD  1 
ATOM 3206  C CE  . LYS A 1 420 ? 49.212  5.598   5.997   1.00 82.33  ? 414 LYS A CE  1 
ATOM 3207  N NZ  . LYS A 1 420 ? 48.525  4.724   6.953   1.00 83.56  ? 414 LYS A NZ  1 
ATOM 3208  N N   . VAL A 1 421 ? 50.994  5.466   -0.767  1.00 89.63  ? 415 VAL A N   1 
ATOM 3209  C CA  . VAL A 1 421 ? 51.051  4.867   -2.103  1.00 90.39  ? 415 VAL A CA  1 
ATOM 3210  C C   . VAL A 1 421 ? 51.180  5.956   -3.180  1.00 85.65  ? 415 VAL A C   1 
ATOM 3211  O O   . VAL A 1 421 ? 50.229  6.239   -3.910  1.00 78.44  ? 415 VAL A O   1 
ATOM 3212  C CB  . VAL A 1 421 ? 49.840  3.942   -2.358  1.00 86.35  ? 415 VAL A CB  1 
ATOM 3213  C CG1 . VAL A 1 421 ? 49.842  2.768   -1.389  1.00 87.99  ? 415 VAL A CG1 1 
ATOM 3214  C CG2 . VAL A 1 421 ? 48.495  4.664   -2.279  1.00 83.59  ? 415 VAL A CG2 1 
ATOM 3215  N N   . PRO A 1 422 ? 52.371  6.589   -3.343  1.00 82.52  ? 416 PRO A N   1 
ATOM 3216  C CA  . PRO A 1 422 ? 52.543  7.671   -4.312  1.00 75.39  ? 416 PRO A CA  1 
ATOM 3217  C C   . PRO A 1 422 ? 52.367  7.205   -5.754  1.00 74.54  ? 416 PRO A C   1 
ATOM 3218  O O   . PRO A 1 422 ? 51.942  7.978   -6.605  1.00 74.81  ? 416 PRO A O   1 
ATOM 3219  C CB  . PRO A 1 422 ? 53.964  8.230   -4.070  1.00 80.24  ? 416 PRO A CB  1 
ATOM 3220  C CG  . PRO A 1 422 ? 54.589  7.390   -2.968  1.00 83.11  ? 416 PRO A CG  1 
ATOM 3221  C CD  . PRO A 1 422 ? 53.613  6.284   -2.611  1.00 88.61  ? 416 PRO A CD  1 
ATOM 3222  N N   . GLN A 1 423 ? 52.672  5.928   -6.012  1.00 78.84  ? 417 GLN A N   1 
ATOM 3223  C CA  . GLN A 1 423 ? 52.648  5.369   -7.356  1.00 79.91  ? 417 GLN A CA  1 
ATOM 3224  C C   . GLN A 1 423 ? 51.266  5.512   -8.000  1.00 80.21  ? 417 GLN A C   1 
ATOM 3225  O O   . GLN A 1 423 ? 51.149  5.408   -9.220  1.00 77.59  ? 417 GLN A O   1 
ATOM 3226  C CB  . GLN A 1 423 ? 53.065  3.898   -7.339  1.00 81.80  ? 417 GLN A CB  1 
ATOM 3227  C CG  . GLN A 1 423 ? 54.478  3.646   -6.817  1.00 91.00  ? 417 GLN A CG  1 
ATOM 3228  C CD  . GLN A 1 423 ? 54.545  3.372   -5.328  1.00 100.45 ? 417 GLN A CD  1 
ATOM 3229  O OE1 . GLN A 1 423 ? 53.527  3.355   -4.625  1.00 109.15 ? 417 GLN A OE1 1 
ATOM 3230  N NE2 . GLN A 1 423 ? 55.751  3.138   -4.829  1.00 99.98  ? 417 GLN A NE2 1 
ATOM 3231  N N   . VAL A 1 424 ? 50.223  5.751   -7.191  1.00 76.86  ? 418 VAL A N   1 
ATOM 3232  C CA  . VAL A 1 424 ? 48.852  5.757   -7.682  1.00 75.83  ? 418 VAL A CA  1 
ATOM 3233  C C   . VAL A 1 424 ? 48.585  7.072   -8.414  1.00 78.19  ? 418 VAL A C   1 
ATOM 3234  O O   . VAL A 1 424 ? 49.226  8.082   -8.123  1.00 70.79  ? 418 VAL A O   1 
ATOM 3235  C CB  . VAL A 1 424 ? 47.833  5.546   -6.545  1.00 79.43  ? 418 VAL A CB  1 
ATOM 3236  C CG1 . VAL A 1 424 ? 46.420  5.317   -7.083  1.00 77.24  ? 418 VAL A CG1 1 
ATOM 3237  C CG2 . VAL A 1 424 ? 48.233  4.409   -5.610  1.00 85.07  ? 418 VAL A CG2 1 
ATOM 3238  N N   . SER A 1 425 ? 47.595  7.045   -9.327  1.00 84.05  ? 419 SER A N   1 
ATOM 3239  C CA  . SER A 1 425 ? 47.309  8.139   -10.249 1.00 78.53  ? 419 SER A CA  1 
ATOM 3240  C C   . SER A 1 425 ? 46.482  9.227   -9.565  1.00 73.08  ? 419 SER A C   1 
ATOM 3241  O O   . SER A 1 425 ? 45.479  8.932   -8.919  1.00 70.20  ? 419 SER A O   1 
ATOM 3242  C CB  . SER A 1 425 ? 46.625  7.634   -11.514 1.00 76.15  ? 419 SER A CB  1 
ATOM 3243  O OG  . SER A 1 425 ? 45.296  7.187   -11.272 1.00 72.30  ? 419 SER A OG  1 
ATOM 3244  N N   . THR A 1 426 ? 46.907  10.486  -9.762  1.00 70.91  ? 420 THR A N   1 
ATOM 3245  C CA  . THR A 1 426 ? 46.432  11.645  -9.012  1.00 69.52  ? 420 THR A CA  1 
ATOM 3246  C C   . THR A 1 426 ? 44.906  11.749  -9.028  1.00 68.86  ? 420 THR A C   1 
ATOM 3247  O O   . THR A 1 426 ? 44.299  11.853  -7.969  1.00 72.59  ? 420 THR A O   1 
ATOM 3248  C CB  . THR A 1 426 ? 47.092  12.912  -9.555  1.00 65.05  ? 420 THR A CB  1 
ATOM 3249  O OG1 . THR A 1 426 ? 48.398  12.874  -8.988  1.00 60.23  ? 420 THR A OG1 1 
ATOM 3250  C CG2 . THR A 1 426 ? 46.373  14.180  -9.136  1.00 65.27  ? 420 THR A CG2 1 
ATOM 3251  N N   . PRO A 1 427 ? 44.229  11.687  -10.195 1.00 63.76  ? 421 PRO A N   1 
ATOM 3252  C CA  . PRO A 1 427 ? 42.773  11.792  -10.235 1.00 61.10  ? 421 PRO A CA  1 
ATOM 3253  C C   . PRO A 1 427 ? 42.077  10.760  -9.354  1.00 64.00  ? 421 PRO A C   1 
ATOM 3254  O O   . PRO A 1 427 ? 40.956  11.015  -8.906  1.00 63.22  ? 421 PRO A O   1 
ATOM 3255  C CB  . PRO A 1 427 ? 42.419  11.565  -11.709 1.00 63.82  ? 421 PRO A CB  1 
ATOM 3256  C CG  . PRO A 1 427 ? 43.706  11.791  -12.469 1.00 64.30  ? 421 PRO A CG  1 
ATOM 3257  C CD  . PRO A 1 427 ? 44.812  11.407  -11.514 1.00 66.59  ? 421 PRO A CD  1 
ATOM 3258  N N   . THR A 1 428 ? 42.740  9.598   -9.168  1.00 65.00  ? 422 THR A N   1 
ATOM 3259  C CA  . THR A 1 428 ? 42.277  8.522   -8.298  1.00 66.01  ? 422 THR A CA  1 
ATOM 3260  C C   . THR A 1 428 ? 42.501  8.910   -6.842  1.00 59.01  ? 422 THR A C   1 
ATOM 3261  O O   . THR A 1 428 ? 41.638  8.662   -6.007  1.00 60.31  ? 422 THR A O   1 
ATOM 3262  C CB  . THR A 1 428 ? 42.986  7.199   -8.604  1.00 73.33  ? 422 THR A CB  1 
ATOM 3263  O OG1 . THR A 1 428 ? 42.590  6.801   -9.915  1.00 87.10  ? 422 THR A OG1 1 
ATOM 3264  C CG2 . THR A 1 428 ? 42.627  6.097   -7.621  1.00 68.43  ? 422 THR A CG2 1 
ATOM 3265  N N   . LEU A 1 429 ? 43.656  9.507   -6.541  1.00 54.42  ? 423 LEU A N   1 
ATOM 3266  C CA  . LEU A 1 429 ? 43.926  9.943   -5.181  1.00 62.84  ? 423 LEU A CA  1 
ATOM 3267  C C   . LEU A 1 429 ? 42.891  10.985  -4.747  1.00 66.32  ? 423 LEU A C   1 
ATOM 3268  O O   . LEU A 1 429 ? 42.393  10.961  -3.627  1.00 70.33  ? 423 LEU A O   1 
ATOM 3269  C CB  . LEU A 1 429 ? 45.356  10.461  -5.027  1.00 63.07  ? 423 LEU A CB  1 
ATOM 3270  C CG  . LEU A 1 429 ? 46.446  9.389   -5.116  1.00 65.78  ? 423 LEU A CG  1 
ATOM 3271  C CD1 . LEU A 1 429 ? 46.792  9.119   -6.545  1.00 68.77  ? 423 LEU A CD1 1 
ATOM 3272  C CD2 . LEU A 1 429 ? 47.713  9.711   -4.368  1.00 69.13  ? 423 LEU A CD2 1 
ATOM 3273  N N   . VAL A 1 430 ? 42.528  11.889  -5.651  1.00 69.46  ? 424 VAL A N   1 
ATOM 3274  C CA  . VAL A 1 430 ? 41.641  12.985  -5.303  1.00 72.61  ? 424 VAL A CA  1 
ATOM 3275  C C   . VAL A 1 430 ? 40.184  12.522  -5.305  1.00 66.30  ? 424 VAL A C   1 
ATOM 3276  O O   . VAL A 1 430 ? 39.291  13.262  -4.911  1.00 60.56  ? 424 VAL A O   1 
ATOM 3277  C CB  . VAL A 1 430 ? 41.907  14.147  -6.276  1.00 78.73  ? 424 VAL A CB  1 
ATOM 3278  C CG1 . VAL A 1 430 ? 40.985  15.336  -6.036  1.00 83.85  ? 424 VAL A CG1 1 
ATOM 3279  C CG2 . VAL A 1 430 ? 43.364  14.600  -6.208  1.00 80.14  ? 424 VAL A CG2 1 
ATOM 3280  N N   . GLU A 1 431 ? 39.930  11.282  -5.719  1.00 71.08  ? 425 GLU A N   1 
ATOM 3281  C CA  . GLU A 1 431 ? 38.570  10.770  -5.701  1.00 80.18  ? 425 GLU A CA  1 
ATOM 3282  C C   . GLU A 1 431 ? 38.337  9.955   -4.429  1.00 81.79  ? 425 GLU A C   1 
ATOM 3283  O O   . GLU A 1 431 ? 37.270  10.036  -3.820  1.00 77.83  ? 425 GLU A O   1 
ATOM 3284  C CB  . GLU A 1 431 ? 38.264  9.978   -6.973  1.00 81.26  ? 425 GLU A CB  1 
ATOM 3285  C CG  . GLU A 1 431 ? 36.777  9.672   -7.129  1.00 85.86  ? 425 GLU A CG  1 
ATOM 3286  C CD  . GLU A 1 431 ? 35.860  10.798  -6.656  1.00 95.61  ? 425 GLU A CD  1 
ATOM 3287  O OE1 . GLU A 1 431 ? 35.861  11.910  -7.231  1.00 98.20  ? 425 GLU A OE1 1 
ATOM 3288  O OE2 . GLU A 1 431 ? 35.146  10.565  -5.660  1.00 101.43 ? 425 GLU A OE2 1 
ATOM 3289  N N   . VAL A 1 432 ? 39.337  9.157   -4.044  1.00 78.38  ? 426 VAL A N   1 
ATOM 3290  C CA  . VAL A 1 432 ? 39.321  8.481   -2.759  1.00 77.97  ? 426 VAL A CA  1 
ATOM 3291  C C   . VAL A 1 432 ? 39.127  9.539   -1.665  1.00 78.99  ? 426 VAL A C   1 
ATOM 3292  O O   . VAL A 1 432 ? 38.058  9.621   -1.055  1.00 80.22  ? 426 VAL A O   1 
ATOM 3293  C CB  . VAL A 1 432 ? 40.623  7.654   -2.619  1.00 75.71  ? 426 VAL A CB  1 
ATOM 3294  C CG1 . VAL A 1 432 ? 40.900  7.148   -1.205  1.00 73.12  ? 426 VAL A CG1 1 
ATOM 3295  C CG2 . VAL A 1 432 ? 40.632  6.475   -3.581  1.00 77.88  ? 426 VAL A CG2 1 
ATOM 3296  N N   . SER A 1 433 ? 40.136  10.408  -1.498  1.00 72.84  ? 427 SER A N   1 
ATOM 3297  C CA  . SER A 1 433 ? 40.283  11.257  -0.324  1.00 64.66  ? 427 SER A CA  1 
ATOM 3298  C C   . SER A 1 433 ? 39.064  12.140  -0.101  1.00 57.34  ? 427 SER A C   1 
ATOM 3299  O O   . SER A 1 433 ? 38.840  12.561  1.027   1.00 52.48  ? 427 SER A O   1 
ATOM 3300  C CB  . SER A 1 433 ? 41.505  12.135  -0.414  1.00 67.25  ? 427 SER A CB  1 
ATOM 3301  O OG  . SER A 1 433 ? 42.693  11.514  0.061   1.00 63.20  ? 427 SER A OG  1 
ATOM 3302  N N   . ARG A 1 434 ? 38.354  12.478  -1.182  1.00 55.13  ? 428 ARG A N   1 
ATOM 3303  C CA  . ARG A 1 434 ? 37.146  13.282  -1.095  1.00 60.24  ? 428 ARG A CA  1 
ATOM 3304  C C   . ARG A 1 434 ? 35.980  12.428  -0.603  1.00 61.38  ? 428 ARG A C   1 
ATOM 3305  O O   . ARG A 1 434 ? 35.169  12.898  0.193   1.00 57.28  ? 428 ARG A O   1 
ATOM 3306  C CB  . ARG A 1 434 ? 36.788  13.892  -2.455  1.00 68.04  ? 428 ARG A CB  1 
ATOM 3307  C CG  . ARG A 1 434 ? 37.733  14.986  -2.928  1.00 66.50  ? 428 ARG A CG  1 
ATOM 3308  C CD  . ARG A 1 434 ? 37.316  15.464  -4.305  1.00 66.73  ? 428 ARG A CD  1 
ATOM 3309  N NE  . ARG A 1 434 ? 36.085  16.262  -4.267  1.00 66.43  ? 428 ARG A NE  1 
ATOM 3310  C CZ  . ARG A 1 434 ? 35.981  17.501  -3.801  1.00 66.10  ? 428 ARG A CZ  1 
ATOM 3311  N NH1 . ARG A 1 434 ? 37.040  18.139  -3.325  1.00 64.29  ? 428 ARG A NH1 1 
ATOM 3312  N NH2 . ARG A 1 434 ? 34.804  18.103  -3.815  1.00 69.01  ? 428 ARG A NH2 1 
ATOM 3313  N N   . ASN A 1 435 ? 35.894  11.183  -1.096  1.00 63.62  ? 429 ASN A N   1 
ATOM 3314  C CA  . ASN A 1 435 ? 34.864  10.257  -0.654  1.00 62.95  ? 429 ASN A CA  1 
ATOM 3315  C C   . ASN A 1 435 ? 35.067  9.933   0.817   1.00 56.90  ? 429 ASN A C   1 
ATOM 3316  O O   . ASN A 1 435 ? 34.107  9.956   1.576   1.00 60.05  ? 429 ASN A O   1 
ATOM 3317  C CB  . ASN A 1 435 ? 34.811  8.993   -1.503  1.00 66.68  ? 429 ASN A CB  1 
ATOM 3318  C CG  . ASN A 1 435 ? 34.060  9.226   -2.793  1.00 73.31  ? 429 ASN A CG  1 
ATOM 3319  O OD1 . ASN A 1 435 ? 33.326  10.215  -2.921  1.00 70.01  ? 429 ASN A OD1 1 
ATOM 3320  N ND2 . ASN A 1 435 ? 34.209  8.323   -3.749  1.00 83.59  ? 429 ASN A ND2 1 
ATOM 3321  N N   . LEU A 1 436 ? 36.321  9.676   1.199   1.00 56.27  ? 430 LEU A N   1 
ATOM 3322  C CA  . LEU A 1 436 ? 36.675  9.342   2.574   1.00 63.66  ? 430 LEU A CA  1 
ATOM 3323  C C   . LEU A 1 436 ? 36.317  10.460  3.560   1.00 58.22  ? 430 LEU A C   1 
ATOM 3324  O O   . LEU A 1 436 ? 35.790  10.188  4.641   1.00 51.42  ? 430 LEU A O   1 
ATOM 3325  C CB  . LEU A 1 436 ? 38.166  9.010   2.653   1.00 65.56  ? 430 LEU A CB  1 
ATOM 3326  C CG  . LEU A 1 436 ? 38.577  7.644   2.094   1.00 65.53  ? 430 LEU A CG  1 
ATOM 3327  C CD1 . LEU A 1 436 ? 39.985  7.290   2.551   1.00 62.64  ? 430 LEU A CD1 1 
ATOM 3328  C CD2 . LEU A 1 436 ? 37.596  6.544   2.476   1.00 64.18  ? 430 LEU A CD2 1 
ATOM 3329  N N   . GLY A 1 437 ? 36.654  11.700  3.199   1.00 54.06  ? 431 GLY A N   1 
ATOM 3330  C CA  . GLY A 1 437 ? 36.308  12.861  3.994   1.00 51.48  ? 431 GLY A CA  1 
ATOM 3331  C C   . GLY A 1 437 ? 34.797  13.066  4.060   1.00 54.20  ? 431 GLY A C   1 
ATOM 3332  O O   . GLY A 1 437 ? 34.318  13.682  5.014   1.00 61.21  ? 431 GLY A O   1 
ATOM 3333  N N   . LYS A 1 438 ? 34.062  12.559  3.053   1.00 51.19  ? 432 LYS A N   1 
ATOM 3334  C CA  . LYS A 1 438 ? 32.603  12.620  3.054   1.00 57.15  ? 432 LYS A CA  1 
ATOM 3335  C C   . LYS A 1 438 ? 32.027  11.570  4.003   1.00 59.26  ? 432 LYS A C   1 
ATOM 3336  O O   . LYS A 1 438 ? 30.899  11.716  4.480   1.00 59.47  ? 432 LYS A O   1 
ATOM 3337  C CB  . LYS A 1 438 ? 31.998  12.435  1.656   1.00 62.79  ? 432 LYS A CB  1 
ATOM 3338  C CG  . LYS A 1 438 ? 32.048  13.676  0.777   1.00 67.98  ? 432 LYS A CG  1 
ATOM 3339  C CD  . LYS A 1 438 ? 31.783  13.422  -0.702  1.00 73.00  ? 432 LYS A CD  1 
ATOM 3340  C CE  . LYS A 1 438 ? 32.000  14.670  -1.508  1.00 79.95  ? 432 LYS A CE  1 
ATOM 3341  N NZ  . LYS A 1 438 ? 31.681  14.499  -2.930  1.00 83.41  ? 432 LYS A NZ  1 
ATOM 3342  N N   . VAL A 1 439 ? 32.803  10.501  4.241   1.00 60.90  ? 433 VAL A N   1 
ATOM 3343  C CA  . VAL A 1 439 ? 32.462  9.472   5.215   1.00 57.00  ? 433 VAL A CA  1 
ATOM 3344  C C   . VAL A 1 439 ? 32.598  10.061  6.617   1.00 56.86  ? 433 VAL A C   1 
ATOM 3345  O O   . VAL A 1 439 ? 31.688  9.932   7.425   1.00 57.07  ? 433 VAL A O   1 
ATOM 3346  C CB  . VAL A 1 439 ? 33.324  8.202   5.092   1.00 53.31  ? 433 VAL A CB  1 
ATOM 3347  C CG1 . VAL A 1 439 ? 32.882  7.154   6.096   1.00 51.82  ? 433 VAL A CG1 1 
ATOM 3348  C CG2 . VAL A 1 439 ? 33.312  7.617   3.686   1.00 55.27  ? 433 VAL A CG2 1 
ATOM 3349  N N   . GLY A 1 440 ? 33.752  10.683  6.895   1.00 57.33  ? 434 GLY A N   1 
ATOM 3350  C CA  . GLY A 1 440 ? 33.944  11.488  8.092   1.00 57.18  ? 434 GLY A CA  1 
ATOM 3351  C C   . GLY A 1 440 ? 32.714  12.337  8.431   1.00 56.44  ? 434 GLY A C   1 
ATOM 3352  O O   . GLY A 1 440 ? 32.329  12.443  9.593   1.00 58.35  ? 434 GLY A O   1 
ATOM 3353  N N   . SER A 1 441 ? 32.095  12.957  7.423   1.00 52.48  ? 435 SER A N   1 
ATOM 3354  C CA  . SER A 1 441 ? 31.010  13.883  7.689   1.00 57.53  ? 435 SER A CA  1 
ATOM 3355  C C   . SER A 1 441 ? 29.680  13.140  7.771   1.00 61.46  ? 435 SER A C   1 
ATOM 3356  O O   . SER A 1 441 ? 28.650  13.765  7.994   1.00 72.31  ? 435 SER A O   1 
ATOM 3357  C CB  . SER A 1 441 ? 30.966  15.011  6.661   1.00 60.67  ? 435 SER A CB  1 
ATOM 3358  O OG  . SER A 1 441 ? 30.503  14.596  5.383   1.00 66.52  ? 435 SER A OG  1 
ATOM 3359  N N   . LYS A 1 442 ? 29.690  11.818  7.574   1.00 65.60  ? 436 LYS A N   1 
ATOM 3360  C CA  . LYS A 1 442 ? 28.467  11.033  7.654   1.00 69.04  ? 436 LYS A CA  1 
ATOM 3361  C C   . LYS A 1 442 ? 28.509  10.097  8.870   1.00 70.30  ? 436 LYS A C   1 
ATOM 3362  O O   . LYS A 1 442 ? 27.491  9.494   9.202   1.00 75.93  ? 436 LYS A O   1 
ATOM 3363  C CB  . LYS A 1 442 ? 28.253  10.343  6.297   1.00 68.16  ? 436 LYS A CB  1 
ATOM 3364  C CG  . LYS A 1 442 ? 26.880  9.722   6.082   1.00 74.77  ? 436 LYS A CG  1 
ATOM 3365  C CD  . LYS A 1 442 ? 25.699  10.687  6.159   1.00 85.21  ? 436 LYS A CD  1 
ATOM 3366  C CE  . LYS A 1 442 ? 24.383  10.009  6.459   1.00 95.38  ? 436 LYS A CE  1 
ATOM 3367  N NZ  . LYS A 1 442 ? 24.243  9.517   7.839   1.00 93.10  ? 436 LYS A NZ  1 
ATOM 3368  N N   . CYS A 1 443 ? 29.664  10.009  9.556   1.00 68.49  ? 437 CYS A N   1 
ATOM 3369  C CA  . CYS A 1 443 ? 29.854  9.100   10.683  1.00 70.11  ? 437 CYS A CA  1 
ATOM 3370  C C   . CYS A 1 443 ? 30.243  9.832   11.970  1.00 67.24  ? 437 CYS A C   1 
ATOM 3371  O O   . CYS A 1 443 ? 29.835  9.420   13.049  1.00 79.25  ? 437 CYS A O   1 
ATOM 3372  C CB  . CYS A 1 443 ? 30.915  8.048   10.388  1.00 75.05  ? 437 CYS A CB  1 
ATOM 3373  S SG  . CYS A 1 443 ? 30.459  6.940   9.029   1.00 82.77  ? 437 CYS A SG  1 
ATOM 3374  N N   . CYS A 1 444 ? 31.042  10.897  11.877  1.00 58.50  ? 438 CYS A N   1 
ATOM 3375  C CA  . CYS A 1 444 ? 31.335  11.720  13.039  1.00 56.65  ? 438 CYS A CA  1 
ATOM 3376  C C   . CYS A 1 444 ? 30.126  12.573  13.432  1.00 58.43  ? 438 CYS A C   1 
ATOM 3377  O O   . CYS A 1 444 ? 30.088  13.110  14.536  1.00 58.16  ? 438 CYS A O   1 
ATOM 3378  C CB  . CYS A 1 444 ? 32.537  12.621  12.791  1.00 60.40  ? 438 CYS A CB  1 
ATOM 3379  S SG  . CYS A 1 444 ? 34.041  11.724  12.324  1.00 55.12  ? 438 CYS A SG  1 
ATOM 3380  N N   . LYS A 1 445 ? 29.152  12.718  12.524  1.00 61.64  ? 439 LYS A N   1 
ATOM 3381  C CA  . LYS A 1 445 ? 27.844  13.278  12.853  1.00 69.48  ? 439 LYS A CA  1 
ATOM 3382  C C   . LYS A 1 445 ? 27.132  12.443  13.924  1.00 79.00  ? 439 LYS A C   1 
ATOM 3383  O O   . LYS A 1 445 ? 26.476  12.989  14.810  1.00 87.83  ? 439 LYS A O   1 
ATOM 3384  C CB  . LYS A 1 445 ? 26.994  13.327  11.577  1.00 74.69  ? 439 LYS A CB  1 
ATOM 3385  C CG  . LYS A 1 445 ? 25.514  13.661  11.740  1.00 82.85  ? 439 LYS A CG  1 
ATOM 3386  C CD  . LYS A 1 445 ? 24.815  14.050  10.438  1.00 93.46  ? 439 LYS A CD  1 
ATOM 3387  C CE  . LYS A 1 445 ? 24.727  12.943  9.419   1.00 96.75  ? 439 LYS A CE  1 
ATOM 3388  N NZ  . LYS A 1 445 ? 24.142  13.403  8.156   1.00 94.87  ? 439 LYS A NZ  1 
ATOM 3389  N N   . HIS A 1 446 ? 27.242  11.110  13.817  1.00 80.48  ? 440 HIS A N   1 
ATOM 3390  C CA  . HIS A 1 446 ? 26.586  10.176  14.721  1.00 70.23  ? 440 HIS A CA  1 
ATOM 3391  C C   . HIS A 1 446 ? 27.284  10.123  16.085  1.00 64.48  ? 440 HIS A C   1 
ATOM 3392  O O   . HIS A 1 446 ? 28.498  10.296  16.201  1.00 53.10  ? 440 HIS A O   1 
ATOM 3393  C CB  . HIS A 1 446 ? 26.556  8.775   14.091  1.00 71.97  ? 440 HIS A CB  1 
ATOM 3394  C CG  . HIS A 1 446 ? 25.578  8.582   12.968  1.00 79.85  ? 440 HIS A CG  1 
ATOM 3395  N ND1 . HIS A 1 446 ? 24.234  8.907   13.018  1.00 86.66  ? 440 HIS A ND1 1 
ATOM 3396  C CD2 . HIS A 1 446 ? 25.778  8.025   11.770  1.00 79.46  ? 440 HIS A CD2 1 
ATOM 3397  C CE1 . HIS A 1 446 ? 23.655  8.575   11.875  1.00 83.03  ? 440 HIS A CE1 1 
ATOM 3398  N NE2 . HIS A 1 446 ? 24.577  8.041   11.101  1.00 89.28  ? 440 HIS A NE2 1 
ATOM 3399  N N   . PRO A 1 447 ? 26.540  9.813   17.170  1.00 65.65  ? 441 PRO A N   1 
ATOM 3400  C CA  . PRO A 1 447 ? 27.163  9.557   18.477  1.00 66.57  ? 441 PRO A CA  1 
ATOM 3401  C C   . PRO A 1 447 ? 28.131  8.374   18.476  1.00 65.64  ? 441 PRO A C   1 
ATOM 3402  O O   . PRO A 1 447 ? 27.926  7.436   17.714  1.00 67.13  ? 441 PRO A O   1 
ATOM 3403  C CB  . PRO A 1 447 ? 25.929  9.272   19.359  1.00 71.34  ? 441 PRO A CB  1 
ATOM 3404  C CG  . PRO A 1 447 ? 24.862  8.774   18.392  1.00 64.77  ? 441 PRO A CG  1 
ATOM 3405  C CD  . PRO A 1 447 ? 25.074  9.647   17.176  1.00 63.52  ? 441 PRO A CD  1 
ATOM 3406  N N   . GLU A 1 448 ? 29.131  8.382   19.375  1.00 67.45  ? 442 GLU A N   1 
ATOM 3407  C CA  . GLU A 1 448 ? 30.199  7.380   19.391  1.00 68.27  ? 442 GLU A CA  1 
ATOM 3408  C C   . GLU A 1 448 ? 29.677  5.955   19.137  1.00 66.42  ? 442 GLU A C   1 
ATOM 3409  O O   . GLU A 1 448 ? 30.345  5.150   18.495  1.00 61.42  ? 442 GLU A O   1 
ATOM 3410  C CB  . GLU A 1 448 ? 30.977  7.442   20.707  1.00 72.10  ? 442 GLU A CB  1 
ATOM 3411  C CG  . GLU A 1 448 ? 32.288  6.654   20.681  1.00 82.34  ? 442 GLU A CG  1 
ATOM 3412  C CD  . GLU A 1 448 ? 33.466  7.346   20.006  1.00 92.30  ? 442 GLU A CD  1 
ATOM 3413  O OE1 . GLU A 1 448 ? 33.902  8.406   20.516  1.00 97.56  ? 442 GLU A OE1 1 
ATOM 3414  O OE2 . GLU A 1 448 ? 33.959  6.827   18.978  1.00 90.23  ? 442 GLU A OE2 1 
ATOM 3415  N N   . ALA A 1 449 ? 28.485  5.638   19.653  1.00 72.13  ? 443 ALA A N   1 
ATOM 3416  C CA  . ALA A 1 449 ? 27.868  4.325   19.517  1.00 68.98  ? 443 ALA A CA  1 
ATOM 3417  C C   . ALA A 1 449 ? 27.925  3.815   18.075  1.00 70.58  ? 443 ALA A C   1 
ATOM 3418  O O   . ALA A 1 449 ? 28.472  2.741   17.813  1.00 77.35  ? 443 ALA A O   1 
ATOM 3419  C CB  . ALA A 1 449 ? 26.438  4.396   20.027  1.00 69.36  ? 443 ALA A CB  1 
ATOM 3420  N N   . LYS A 1 450 ? 27.398  4.609   17.135  1.00 70.45  ? 444 LYS A N   1 
ATOM 3421  C CA  . LYS A 1 450 ? 27.031  4.115   15.811  1.00 71.78  ? 444 LYS A CA  1 
ATOM 3422  C C   . LYS A 1 450 ? 28.115  4.341   14.749  1.00 65.47  ? 444 LYS A C   1 
ATOM 3423  O O   . LYS A 1 450 ? 27.847  4.152   13.562  1.00 55.64  ? 444 LYS A O   1 
ATOM 3424  C CB  . LYS A 1 450 ? 25.760  4.812   15.309  1.00 72.37  ? 444 LYS A CB  1 
ATOM 3425  C CG  . LYS A 1 450 ? 24.609  4.874   16.303  1.00 77.57  ? 444 LYS A CG  1 
ATOM 3426  C CD  . LYS A 1 450 ? 23.298  5.374   15.707  1.00 78.05  ? 444 LYS A CD  1 
ATOM 3427  C CE  . LYS A 1 450 ? 22.795  4.481   14.621  1.00 82.85  ? 444 LYS A CE  1 
ATOM 3428  N NZ  . LYS A 1 450 ? 21.356  4.663   14.425  1.00 88.19  ? 444 LYS A NZ  1 
ATOM 3429  N N   . ARG A 1 451 ? 29.341  4.696   15.158  1.00 62.49  ? 445 ARG A N   1 
ATOM 3430  C CA  . ARG A 1 451 ? 30.371  5.102   14.211  1.00 60.28  ? 445 ARG A CA  1 
ATOM 3431  C C   . ARG A 1 451 ? 30.972  3.921   13.454  1.00 61.55  ? 445 ARG A C   1 
ATOM 3432  O O   . ARG A 1 451 ? 31.031  3.962   12.225  1.00 59.37  ? 445 ARG A O   1 
ATOM 3433  C CB  . ARG A 1 451 ? 31.473  5.887   14.916  1.00 57.93  ? 445 ARG A CB  1 
ATOM 3434  C CG  . ARG A 1 451 ? 30.898  7.244   15.285  1.00 62.75  ? 445 ARG A CG  1 
ATOM 3435  C CD  . ARG A 1 451 ? 31.917  8.189   15.878  1.00 66.26  ? 445 ARG A CD  1 
ATOM 3436  N NE  . ARG A 1 451 ? 31.234  9.395   16.351  1.00 69.67  ? 445 ARG A NE  1 
ATOM 3437  C CZ  . ARG A 1 451 ? 31.804  10.325  17.097  1.00 77.07  ? 445 ARG A CZ  1 
ATOM 3438  N NH1 . ARG A 1 451 ? 33.090  10.230  17.427  1.00 73.52  ? 445 ARG A NH1 1 
ATOM 3439  N NH2 . ARG A 1 451 ? 31.070  11.351  17.498  1.00 83.68  ? 445 ARG A NH2 1 
ATOM 3440  N N   . MET A 1 452 ? 31.412  2.893   14.195  1.00 65.53  ? 446 MET A N   1 
ATOM 3441  C CA  . MET A 1 452 ? 32.065  1.722   13.619  1.00 64.83  ? 446 MET A CA  1 
ATOM 3442  C C   . MET A 1 452 ? 31.141  0.966   12.657  1.00 61.21  ? 446 MET A C   1 
ATOM 3443  O O   . MET A 1 452 ? 31.586  0.553   11.596  1.00 60.12  ? 446 MET A O   1 
ATOM 3444  C CB  . MET A 1 452 ? 32.578  0.759   14.700  1.00 63.48  ? 446 MET A CB  1 
ATOM 3445  C CG  . MET A 1 452 ? 33.555  -0.263  14.160  1.00 62.50  ? 446 MET A CG  1 
ATOM 3446  S SD  . MET A 1 452 ? 34.439  -1.262  15.375  1.00 61.45  ? 446 MET A SD  1 
ATOM 3447  C CE  . MET A 1 452 ? 35.108  0.034   16.429  1.00 59.28  ? 446 MET A CE  1 
ATOM 3448  N N   . PRO A 1 453 ? 29.850  0.708   12.963  1.00 59.70  ? 447 PRO A N   1 
ATOM 3449  C CA  . PRO A 1 453 ? 28.950  0.139   11.959  1.00 58.47  ? 447 PRO A CA  1 
ATOM 3450  C C   . PRO A 1 453 ? 28.827  0.992   10.698  1.00 64.00  ? 447 PRO A C   1 
ATOM 3451  O O   . PRO A 1 453 ? 28.857  0.460   9.587   1.00 65.27  ? 447 PRO A O   1 
ATOM 3452  C CB  . PRO A 1 453 ? 27.625  0.047   12.715  1.00 57.11  ? 447 PRO A CB  1 
ATOM 3453  C CG  . PRO A 1 453 ? 28.041  -0.059  14.160  1.00 58.49  ? 447 PRO A CG  1 
ATOM 3454  C CD  . PRO A 1 453 ? 29.205  0.894   14.273  1.00 60.05  ? 447 PRO A CD  1 
ATOM 3455  N N   . CYS A 1 454 ? 28.677  2.311   10.897  1.00 72.71  ? 448 CYS A N   1 
ATOM 3456  C CA  . CYS A 1 454 ? 28.478  3.267   9.816   1.00 71.55  ? 448 CYS A CA  1 
ATOM 3457  C C   . CYS A 1 454 ? 29.741  3.372   8.963   1.00 61.57  ? 448 CYS A C   1 
ATOM 3458  O O   . CYS A 1 454 ? 29.657  3.418   7.735   1.00 58.12  ? 448 CYS A O   1 
ATOM 3459  C CB  . CYS A 1 454 ? 28.089  4.638   10.360  1.00 78.66  ? 448 CYS A CB  1 
ATOM 3460  S SG  . CYS A 1 454 ? 27.784  5.873   9.068   1.00 84.40  ? 448 CYS A SG  1 
ATOM 3461  N N   . ALA A 1 455 ? 30.904  3.410   9.628   1.00 51.81  ? 449 ALA A N   1 
ATOM 3462  C CA  . ALA A 1 455 ? 32.192  3.452   8.950   1.00 50.45  ? 449 ALA A CA  1 
ATOM 3463  C C   . ALA A 1 455 ? 32.411  2.223   8.069   1.00 55.12  ? 449 ALA A C   1 
ATOM 3464  O O   . ALA A 1 455 ? 32.724  2.365   6.892   1.00 64.72  ? 449 ALA A O   1 
ATOM 3465  C CB  . ALA A 1 455 ? 33.300  3.582   9.955   1.00 47.82  ? 449 ALA A CB  1 
ATOM 3466  N N   . GLU A 1 456 ? 32.274  1.026   8.655   1.00 61.22  ? 450 GLU A N   1 
ATOM 3467  C CA  . GLU A 1 456 ? 32.269  -0.249  7.939   1.00 61.36  ? 450 GLU A CA  1 
ATOM 3468  C C   . GLU A 1 456 ? 31.423  -0.135  6.669   1.00 58.95  ? 450 GLU A C   1 
ATOM 3469  O O   . GLU A 1 456 ? 31.910  -0.384  5.569   1.00 61.36  ? 450 GLU A O   1 
ATOM 3470  C CB  . GLU A 1 456 ? 31.746  -1.351  8.873   1.00 63.02  ? 450 GLU A CB  1 
ATOM 3471  C CG  . GLU A 1 456 ? 31.445  -2.695  8.210   1.00 66.34  ? 450 GLU A CG  1 
ATOM 3472  C CD  . GLU A 1 456 ? 30.475  -3.604  8.960   1.00 76.16  ? 450 GLU A CD  1 
ATOM 3473  O OE1 . GLU A 1 456 ? 29.306  -3.207  9.265   1.00 70.63  ? 450 GLU A OE1 1 
ATOM 3474  O OE2 . GLU A 1 456 ? 30.900  -4.760  9.209   1.00 81.05  ? 450 GLU A OE2 1 
ATOM 3475  N N   . ASP A 1 457 ? 30.155  0.246   6.843   1.00 53.96  ? 451 ASP A N   1 
ATOM 3476  C CA  . ASP A 1 457 ? 29.204  0.366   5.755   1.00 55.59  ? 451 ASP A CA  1 
ATOM 3477  C C   . ASP A 1 457 ? 29.851  1.111   4.583   1.00 61.15  ? 451 ASP A C   1 
ATOM 3478  O O   . ASP A 1 457 ? 29.987  0.549   3.499   1.00 58.66  ? 451 ASP A O   1 
ATOM 3479  C CB  . ASP A 1 457 ? 27.932  0.980   6.316   1.00 61.38  ? 451 ASP A CB  1 
ATOM 3480  C CG  . ASP A 1 457 ? 26.763  1.185   5.363   1.00 72.47  ? 451 ASP A CG  1 
ATOM 3481  O OD1 . ASP A 1 457 ? 26.943  1.874   4.323   1.00 75.47  ? 451 ASP A OD1 1 
ATOM 3482  O OD2 . ASP A 1 457 ? 25.662  0.702   5.707   1.00 77.53  ? 451 ASP A OD2 1 
ATOM 3483  N N   . TYR A 1 458 ? 30.288  2.363   4.813   1.00 71.98  ? 452 TYR A N   1 
ATOM 3484  C CA  . TYR A 1 458 ? 30.738  3.261   3.748   1.00 70.37  ? 452 TYR A CA  1 
ATOM 3485  C C   . TYR A 1 458 ? 32.105  2.832   3.212   1.00 67.23  ? 452 TYR A C   1 
ATOM 3486  O O   . TYR A 1 458 ? 32.319  2.897   2.009   1.00 66.66  ? 452 TYR A O   1 
ATOM 3487  C CB  . TYR A 1 458 ? 30.769  4.749   4.150   1.00 64.19  ? 452 TYR A CB  1 
ATOM 3488  C CG  . TYR A 1 458 ? 29.375  5.362   4.188   1.00 60.71  ? 452 TYR A CG  1 
ATOM 3489  C CD1 . TYR A 1 458 ? 28.600  5.405   3.036   1.00 62.35  ? 452 TYR A CD1 1 
ATOM 3490  C CD2 . TYR A 1 458 ? 28.815  5.839   5.367   1.00 57.25  ? 452 TYR A CD2 1 
ATOM 3491  C CE1 . TYR A 1 458 ? 27.310  5.904   3.054   1.00 67.54  ? 452 TYR A CE1 1 
ATOM 3492  C CE2 . TYR A 1 458 ? 27.527  6.348   5.395   1.00 62.17  ? 452 TYR A CE2 1 
ATOM 3493  C CZ  . TYR A 1 458 ? 26.769  6.379   4.236   1.00 68.33  ? 452 TYR A CZ  1 
ATOM 3494  O OH  . TYR A 1 458 ? 25.489  6.867   4.237   1.00 71.14  ? 452 TYR A OH  1 
ATOM 3495  N N   . LEU A 1 459 ? 33.020  2.409   4.095   1.00 64.35  ? 453 LEU A N   1 
ATOM 3496  C CA  . LEU A 1 459 ? 34.388  2.091   3.711   1.00 65.63  ? 453 LEU A CA  1 
ATOM 3497  C C   . LEU A 1 459 ? 34.436  0.854   2.818   1.00 70.10  ? 453 LEU A C   1 
ATOM 3498  O O   . LEU A 1 459 ? 35.387  0.655   2.062   1.00 75.63  ? 453 LEU A O   1 
ATOM 3499  C CB  . LEU A 1 459 ? 35.273  1.835   4.931   1.00 71.63  ? 453 LEU A CB  1 
ATOM 3500  C CG  . LEU A 1 459 ? 35.731  3.032   5.776   1.00 75.82  ? 453 LEU A CG  1 
ATOM 3501  C CD1 . LEU A 1 459 ? 37.156  2.762   6.245   1.00 71.78  ? 453 LEU A CD1 1 
ATOM 3502  C CD2 . LEU A 1 459 ? 35.640  4.388   5.107   1.00 77.97  ? 453 LEU A CD2 1 
ATOM 3503  N N   . SER A 1 460 ? 33.465  -0.043  2.969   1.00 73.75  ? 454 SER A N   1 
ATOM 3504  C CA  . SER A 1 460 ? 33.557  -1.320  2.285   1.00 73.45  ? 454 SER A CA  1 
ATOM 3505  C C   . SER A 1 460 ? 33.339  -1.119  0.788   1.00 70.86  ? 454 SER A C   1 
ATOM 3506  O O   . SER A 1 460 ? 34.028  -1.755  -0.003  1.00 66.76  ? 454 SER A O   1 
ATOM 3507  C CB  . SER A 1 460 ? 32.615  -2.329  2.878   1.00 73.09  ? 454 SER A CB  1 
ATOM 3508  O OG  . SER A 1 460 ? 31.304  -1.792  2.934   1.00 73.33  ? 454 SER A OG  1 
ATOM 3509  N N   . VAL A 1 461 ? 32.419  -0.208  0.416   1.00 72.04  ? 455 VAL A N   1 
ATOM 3510  C CA  . VAL A 1 461 ? 32.200  0.147   -0.985  1.00 70.58  ? 455 VAL A CA  1 
ATOM 3511  C C   . VAL A 1 461 ? 33.505  0.719   -1.547  1.00 73.46  ? 455 VAL A C   1 
ATOM 3512  O O   . VAL A 1 461 ? 33.935  0.343   -2.635  1.00 81.13  ? 455 VAL A O   1 
ATOM 3513  C CB  . VAL A 1 461 ? 31.008  1.086   -1.307  1.00 62.92  ? 455 VAL A CB  1 
ATOM 3514  C CG1 . VAL A 1 461 ? 29.652  0.427   -1.070  1.00 60.08  ? 455 VAL A CG1 1 
ATOM 3515  C CG2 . VAL A 1 461 ? 31.066  2.418   -0.569  1.00 69.42  ? 455 VAL A CG2 1 
ATOM 3516  N N   . VAL A 1 462 ? 34.165  1.589   -0.778  1.00 74.90  ? 456 VAL A N   1 
ATOM 3517  C CA  . VAL A 1 462 ? 35.286  2.368   -1.280  1.00 78.28  ? 456 VAL A CA  1 
ATOM 3518  C C   . VAL A 1 462 ? 36.520  1.479   -1.445  1.00 78.39  ? 456 VAL A C   1 
ATOM 3519  O O   . VAL A 1 462 ? 37.320  1.689   -2.352  1.00 91.83  ? 456 VAL A O   1 
ATOM 3520  C CB  . VAL A 1 462 ? 35.586  3.570   -0.364  1.00 78.66  ? 456 VAL A CB  1 
ATOM 3521  C CG1 . VAL A 1 462 ? 36.536  4.561   -1.030  1.00 86.62  ? 456 VAL A CG1 1 
ATOM 3522  C CG2 . VAL A 1 462 ? 34.313  4.285   0.074   1.00 73.39  ? 456 VAL A CG2 1 
ATOM 3523  N N   . LEU A 1 463 ? 36.684  0.491   -0.566  1.00 68.87  ? 457 LEU A N   1 
ATOM 3524  C CA  . LEU A 1 463 ? 37.768  -0.462  -0.717  1.00 74.54  ? 457 LEU A CA  1 
ATOM 3525  C C   . LEU A 1 463 ? 37.411  -1.513  -1.779  1.00 79.55  ? 457 LEU A C   1 
ATOM 3526  O O   . LEU A 1 463 ? 38.284  -2.165  -2.356  1.00 66.52  ? 457 LEU A O   1 
ATOM 3527  C CB  . LEU A 1 463 ? 38.021  -1.056  0.667   1.00 77.27  ? 457 LEU A CB  1 
ATOM 3528  C CG  . LEU A 1 463 ? 38.352  -0.060  1.788   1.00 77.58  ? 457 LEU A CG  1 
ATOM 3529  C CD1 . LEU A 1 463 ? 38.770  -0.759  3.071   1.00 75.57  ? 457 LEU A CD1 1 
ATOM 3530  C CD2 . LEU A 1 463 ? 39.427  0.915   1.364   1.00 77.45  ? 457 LEU A CD2 1 
ATOM 3531  N N   . ASN A 1 464 ? 36.109  -1.673  -2.043  1.00 87.85  ? 458 ASN A N   1 
ATOM 3532  C CA  . ASN A 1 464 ? 35.614  -2.591  -3.059  1.00 95.38  ? 458 ASN A CA  1 
ATOM 3533  C C   . ASN A 1 464 ? 35.953  -2.068  -4.453  1.00 97.49  ? 458 ASN A C   1 
ATOM 3534  O O   . ASN A 1 464 ? 36.502  -2.799  -5.275  1.00 98.99  ? 458 ASN A O   1 
ATOM 3535  C CB  . ASN A 1 464 ? 34.108  -2.793  -2.913  1.00 99.08  ? 458 ASN A CB  1 
ATOM 3536  C CG  . ASN A 1 464 ? 33.476  -3.513  -4.082  1.00 91.63  ? 458 ASN A CG  1 
ATOM 3537  O OD1 . ASN A 1 464 ? 33.945  -4.594  -4.469  1.00 75.01  ? 458 ASN A OD1 1 
ATOM 3538  N ND2 . ASN A 1 464 ? 32.405  -2.942  -4.625  1.00 81.69  ? 458 ASN A ND2 1 
ATOM 3539  N N   . GLN A 1 465 ? 35.584  -0.806  -4.705  1.00 86.40  ? 459 GLN A N   1 
ATOM 3540  C CA  . GLN A 1 465 ? 35.814  -0.167  -5.987  1.00 73.63  ? 459 GLN A CA  1 
ATOM 3541  C C   . GLN A 1 465 ? 37.304  0.081   -6.177  1.00 65.82  ? 459 GLN A C   1 
ATOM 3542  O O   . GLN A 1 465 ? 37.824  -0.169  -7.253  1.00 66.80  ? 459 GLN A O   1 
ATOM 3543  C CB  . GLN A 1 465 ? 35.015  1.127   -6.053  1.00 77.70  ? 459 GLN A CB  1 
ATOM 3544  C CG  . GLN A 1 465 ? 33.511  0.900   -5.961  1.00 84.88  ? 459 GLN A CG  1 
ATOM 3545  C CD  . GLN A 1 465 ? 32.755  2.151   -5.574  1.00 96.30  ? 459 GLN A CD  1 
ATOM 3546  O OE1 . GLN A 1 465 ? 33.228  2.964   -4.767  1.00 104.57 ? 459 GLN A OE1 1 
ATOM 3547  N NE2 . GLN A 1 465 ? 31.574  2.324   -6.152  1.00 96.66  ? 459 GLN A NE2 1 
ATOM 3548  N N   . LEU A 1 466 ? 37.993  0.531   -5.124  1.00 63.68  ? 460 LEU A N   1 
ATOM 3549  C CA  . LEU A 1 466 ? 39.434  0.737   -5.175  1.00 69.77  ? 460 LEU A CA  1 
ATOM 3550  C C   . LEU A 1 466 ? 40.173  -0.543  -5.594  1.00 79.04  ? 460 LEU A C   1 
ATOM 3551  O O   . LEU A 1 466 ? 41.160  -0.451  -6.325  1.00 77.34  ? 460 LEU A O   1 
ATOM 3552  C CB  . LEU A 1 466 ? 39.894  1.268   -3.817  1.00 72.37  ? 460 LEU A CB  1 
ATOM 3553  C CG  . LEU A 1 466 ? 41.375  1.631   -3.677  1.00 77.63  ? 460 LEU A CG  1 
ATOM 3554  C CD1 . LEU A 1 466 ? 41.851  2.719   -4.623  1.00 79.13  ? 460 LEU A CD1 1 
ATOM 3555  C CD2 . LEU A 1 466 ? 41.591  2.057   -2.246  1.00 81.89  ? 460 LEU A CD2 1 
ATOM 3556  N N   . CYS A 1 467 ? 39.789  -1.688  -5.033  1.00 91.06  ? 461 CYS A N   1 
ATOM 3557  C CA  . CYS A 1 467 ? 40.567  -2.933  -5.303  1.00 83.58  ? 461 CYS A CA  1 
ATOM 3558  C C   . CYS A 1 467 ? 40.146  -3.478  -6.682  1.00 75.22  ? 461 CYS A C   1 
ATOM 3559  O O   . CYS A 1 467 ? 40.982  -4.118  -7.332  1.00 71.45  ? 461 CYS A O   1 
ATOM 3560  C CB  . CYS A 1 467 ? 40.532  -3.878  -4.094  1.00 72.99  ? 461 CYS A CB  1 
ATOM 3561  S SG  . CYS A 1 467 ? 41.689  -3.394  -2.787  1.00 54.25  ? 461 CYS A SG  1 
ATOM 3562  N N   . VAL A 1 468 ? 38.908  -3.239  -7.104  1.00 68.76  ? 462 VAL A N   1 
ATOM 3563  C CA  . VAL A 1 468 ? 38.535  -3.646  -8.485  1.00 70.51  ? 462 VAL A CA  1 
ATOM 3564  C C   . VAL A 1 468 ? 39.400  -2.846  -9.468  1.00 78.07  ? 462 VAL A C   1 
ATOM 3565  O O   . VAL A 1 468 ? 39.916  -3.434  -10.434 1.00 78.11  ? 462 VAL A O   1 
ATOM 3566  C CB  . VAL A 1 468 ? 37.040  -3.356  -8.707  1.00 64.60  ? 462 VAL A CB  1 
ATOM 3567  C CG1 . VAL A 1 468 ? 36.697  -3.148  -10.176 1.00 57.56  ? 462 VAL A CG1 1 
ATOM 3568  C CG2 . VAL A 1 468 ? 36.144  -4.414  -8.082  1.00 58.36  ? 462 VAL A CG2 1 
ATOM 3569  N N   . LEU A 1 469 ? 39.593  -1.560  -9.202  1.00 75.31  ? 463 LEU A N   1 
ATOM 3570  C CA  . LEU A 1 469 ? 40.373  -0.714  -10.130 1.00 79.55  ? 463 LEU A CA  1 
ATOM 3571  C C   . LEU A 1 469 ? 41.839  -1.131  -10.083 1.00 83.44  ? 463 LEU A C   1 
ATOM 3572  O O   . LEU A 1 469 ? 42.462  -1.219  -11.148 1.00 97.28  ? 463 LEU A O   1 
ATOM 3573  C CB  . LEU A 1 469 ? 40.222  0.753   -9.748  1.00 83.46  ? 463 LEU A CB  1 
ATOM 3574  C CG  . LEU A 1 469 ? 41.165  1.744   -10.436 1.00 80.32  ? 463 LEU A CG  1 
ATOM 3575  C CD1 . LEU A 1 469 ? 41.045  1.660   -11.946 1.00 77.72  ? 463 LEU A CD1 1 
ATOM 3576  C CD2 . LEU A 1 469 ? 40.848  3.147   -9.958  1.00 75.86  ? 463 LEU A CD2 1 
ATOM 3577  N N   . HIS A 1 470 ? 42.363  -1.417  -8.900  1.00 76.53  ? 464 HIS A N   1 
ATOM 3578  C CA  . HIS A 1 470 ? 43.814  -1.699  -8.834  1.00 75.24  ? 464 HIS A CA  1 
ATOM 3579  C C   . HIS A 1 470 ? 44.056  -2.941  -9.680  1.00 92.37  ? 464 HIS A C   1 
ATOM 3580  O O   . HIS A 1 470 ? 45.080  -3.040  -10.328 1.00 119.60 ? 464 HIS A O   1 
ATOM 3581  C CB  . HIS A 1 470 ? 44.306  -1.871  -7.403  1.00 70.71  ? 464 HIS A CB  1 
ATOM 3582  C CG  . HIS A 1 470 ? 45.787  -1.901  -7.272  1.00 75.44  ? 464 HIS A CG  1 
ATOM 3583  N ND1 . HIS A 1 470 ? 46.496  -3.077  -7.204  1.00 84.84  ? 464 HIS A ND1 1 
ATOM 3584  C CD2 . HIS A 1 470 ? 46.688  -0.923  -7.185  1.00 78.02  ? 464 HIS A CD2 1 
ATOM 3585  C CE1 . HIS A 1 470 ? 47.783  -2.802  -7.084  1.00 76.38  ? 464 HIS A CE1 1 
ATOM 3586  N NE2 . HIS A 1 470 ? 47.922  -1.501  -7.069  1.00 69.17  ? 464 HIS A NE2 1 
ATOM 3587  N N   . GLU A 1 471 ? 43.117  -3.874  -9.754  1.00 94.47  ? 465 GLU A N   1 
ATOM 3588  C CA  . GLU A 1 471 ? 43.450  -5.070  -10.571 1.00 95.12  ? 465 GLU A CA  1 
ATOM 3589  C C   . GLU A 1 471 ? 43.370  -4.678  -12.047 1.00 96.93  ? 465 GLU A C   1 
ATOM 3590  O O   . GLU A 1 471 ? 44.171  -5.187  -12.849 1.00 97.58  ? 465 GLU A O   1 
ATOM 3591  C CB  . GLU A 1 471 ? 42.546  -6.267  -10.299 1.00 97.12  ? 465 GLU A CB  1 
ATOM 3592  C CG  . GLU A 1 471 ? 42.685  -7.384  -11.329 1.00 97.01  ? 465 GLU A CG  1 
ATOM 3593  C CD  . GLU A 1 471 ? 43.682  -8.466  -10.958 1.00 108.29 ? 465 GLU A CD  1 
ATOM 3594  O OE1 . GLU A 1 471 ? 43.328  -9.337  -10.138 1.00 123.67 ? 465 GLU A OE1 1 
ATOM 3595  O OE2 . GLU A 1 471 ? 44.810  -8.439  -11.489 1.00 109.48 ? 465 GLU A OE2 1 
ATOM 3596  N N   . LYS A 1 472 ? 42.481  -3.742  -12.364 1.00 97.35  ? 466 LYS A N   1 
ATOM 3597  C CA  . LYS A 1 472 ? 42.316  -3.337  -13.777 1.00 94.22  ? 466 LYS A CA  1 
ATOM 3598  C C   . LYS A 1 472 ? 43.657  -2.749  -14.200 1.00 100.09 ? 466 LYS A C   1 
ATOM 3599  O O   . LYS A 1 472 ? 44.109  -3.032  -15.321 1.00 108.13 ? 466 LYS A O   1 
ATOM 3600  C CB  . LYS A 1 472 ? 41.188  -2.316  -13.931 1.00 83.70  ? 466 LYS A CB  1 
ATOM 3601  C CG  . LYS A 1 472 ? 39.788  -2.888  -13.828 1.00 85.91  ? 466 LYS A CG  1 
ATOM 3602  C CD  . LYS A 1 472 ? 38.754  -1.999  -14.506 1.00 97.94  ? 466 LYS A CD  1 
ATOM 3603  C CE  . LYS A 1 472 ? 37.400  -2.129  -13.891 1.00 106.25 ? 466 LYS A CE  1 
ATOM 3604  N NZ  . LYS A 1 472 ? 36.912  -0.842  -13.393 1.00 108.06 ? 466 LYS A NZ  1 
ATOM 3605  N N   . THR A 1 473 ? 44.231  -1.942  -13.302 1.00 97.17  ? 467 THR A N   1 
ATOM 3606  C CA  . THR A 1 473 ? 45.493  -1.248  -13.582 1.00 96.62  ? 467 THR A CA  1 
ATOM 3607  C C   . THR A 1 473 ? 46.358  -1.268  -12.343 1.00 94.83  ? 467 THR A C   1 
ATOM 3608  O O   . THR A 1 473 ? 46.449  -0.228  -11.671 1.00 97.88  ? 467 THR A O   1 
ATOM 3609  C CB  . THR A 1 473 ? 45.128  0.182   -13.951 1.00 95.36  ? 467 THR A CB  1 
ATOM 3610  O OG1 . THR A 1 473 ? 44.191  0.567   -12.952 1.00 87.62  ? 467 THR A OG1 1 
ATOM 3611  C CG2 . THR A 1 473 ? 44.501  0.290   -15.328 1.00 92.91  ? 467 THR A CG2 1 
ATOM 3612  N N   . PRO A 1 474 ? 46.993  -2.403  -11.997 1.00 87.62  ? 468 PRO A N   1 
ATOM 3613  C CA  . PRO A 1 474 ? 47.813  -2.494  -10.796 1.00 82.01  ? 468 PRO A CA  1 
ATOM 3614  C C   . PRO A 1 474 ? 49.057  -1.629  -10.794 1.00 74.69  ? 468 PRO A C   1 
ATOM 3615  O O   . PRO A 1 474 ? 49.711  -1.516  -11.836 1.00 78.40  ? 468 PRO A O   1 
ATOM 3616  C CB  . PRO A 1 474 ? 48.145  -3.977  -10.788 1.00 85.07  ? 468 PRO A CB  1 
ATOM 3617  C CG  . PRO A 1 474 ? 48.153  -4.367  -12.239 1.00 83.83  ? 468 PRO A CG  1 
ATOM 3618  C CD  . PRO A 1 474 ? 46.955  -3.624  -12.775 1.00 82.18  ? 468 PRO A CD  1 
ATOM 3619  N N   . VAL A 1 475 ? 49.401  -1.059  -9.645  1.00 72.26  ? 469 VAL A N   1 
ATOM 3620  C CA  . VAL A 1 475 ? 50.559  -0.122  -9.571  1.00 76.00  ? 469 VAL A CA  1 
ATOM 3621  C C   . VAL A 1 475 ? 51.376  -0.424  -8.306  1.00 79.54  ? 469 VAL A C   1 
ATOM 3622  O O   . VAL A 1 475 ? 52.580  -0.134  -8.329  1.00 86.54  ? 469 VAL A O   1 
ATOM 3623  C CB  . VAL A 1 475 ? 50.053  1.326   -9.639  1.00 79.24  ? 469 VAL A CB  1 
ATOM 3624  C CG1 . VAL A 1 475 ? 49.841  1.930   -8.259  1.00 76.88  ? 469 VAL A CG1 1 
ATOM 3625  C CG2 . VAL A 1 475 ? 50.959  2.202   -10.491 1.00 82.39  ? 469 VAL A CG2 1 
ATOM 3626  N N   . SER A 1 476 ? 50.761  -0.919  -7.231  1.00 79.08  ? 470 SER A N   1 
ATOM 3627  C CA  . SER A 1 476 ? 51.547  -1.418  -6.064  1.00 86.35  ? 470 SER A CA  1 
ATOM 3628  C C   . SER A 1 476 ? 51.241  -2.855  -5.626  1.00 87.07  ? 470 SER A C   1 
ATOM 3629  O O   . SER A 1 476 ? 50.061  -3.217  -5.529  1.00 80.43  ? 470 SER A O   1 
ATOM 3630  C CB  . SER A 1 476 ? 51.393  -0.508  -4.885  1.00 88.58  ? 470 SER A CB  1 
ATOM 3631  O OG  . SER A 1 476 ? 52.008  -1.070  -3.735  1.00 85.73  ? 470 SER A OG  1 
ATOM 3632  N N   . ASP A 1 477 ? 52.289  -3.625  -5.352  1.00 89.55  ? 471 ASP A N   1 
ATOM 3633  C CA  . ASP A 1 477 ? 52.139  -5.019  -4.858  1.00 93.65  ? 471 ASP A CA  1 
ATOM 3634  C C   . ASP A 1 477 ? 51.445  -5.037  -3.496  1.00 81.83  ? 471 ASP A C   1 
ATOM 3635  O O   . ASP A 1 477 ? 50.611  -5.922  -3.268  1.00 80.44  ? 471 ASP A O   1 
ATOM 3636  C CB  . ASP A 1 477 ? 53.487  -5.722  -4.850  1.00 104.53 ? 471 ASP A CB  1 
ATOM 3637  C CG  . ASP A 1 477 ? 54.703  -4.849  -4.574  1.00 110.28 ? 471 ASP A CG  1 
ATOM 3638  O OD1 . ASP A 1 477 ? 54.514  -3.695  -4.141  1.00 122.59 ? 471 ASP A OD1 1 
ATOM 3639  O OD2 . ASP A 1 477 ? 55.833  -5.335  -4.790  1.00 101.21 ? 471 ASP A OD2 1 
ATOM 3640  N N   . ARG A 1 478 ? 51.785  -4.098  -2.625  1.00 72.07  ? 472 ARG A N   1 
ATOM 3641  C CA  . ARG A 1 478 ? 51.233  -4.109  -1.257  1.00 67.33  ? 472 ARG A CA  1 
ATOM 3642  C C   . ARG A 1 478 ? 49.718  -3.943  -1.317  1.00 67.56  ? 472 ARG A C   1 
ATOM 3643  O O   . ARG A 1 478 ? 49.026  -4.601  -0.536  1.00 71.79  ? 472 ARG A O   1 
ATOM 3644  C CB  . ARG A 1 478 ? 51.882  -2.944  -0.519  1.00 70.87  ? 472 ARG A CB  1 
ATOM 3645  C CG  . ARG A 1 478 ? 53.324  -2.631  -0.883  1.00 76.81  ? 472 ARG A CG  1 
ATOM 3646  C CD  . ARG A 1 478 ? 53.965  -1.739  0.169   1.00 83.34  ? 472 ARG A CD  1 
ATOM 3647  N NE  . ARG A 1 478 ? 53.392  -0.389  0.199   1.00 91.05  ? 472 ARG A NE  1 
ATOM 3648  C CZ  . ARG A 1 478 ? 53.455  0.441   1.233   1.00 95.21  ? 472 ARG A CZ  1 
ATOM 3649  N NH1 . ARG A 1 478 ? 53.632  -0.034  2.452   1.00 87.54  ? 472 ARG A NH1 1 
ATOM 3650  N NH2 . ARG A 1 478 ? 53.339  1.742   1.046   1.00 100.32 ? 472 ARG A NH2 1 
ATOM 3651  N N   . VAL A 1 479 ? 49.232  -3.076  -2.195  1.00 70.89  ? 473 VAL A N   1 
ATOM 3652  C CA  . VAL A 1 479 ? 47.772  -2.830  -2.332  1.00 69.73  ? 473 VAL A CA  1 
ATOM 3653  C C   . VAL A 1 479 ? 47.099  -4.121  -2.785  1.00 69.49  ? 473 VAL A C   1 
ATOM 3654  O O   . VAL A 1 479 ? 46.009  -4.444  -2.294  1.00 66.68  ? 473 VAL A O   1 
ATOM 3655  C CB  . VAL A 1 479 ? 47.529  -1.709  -3.349  1.00 73.03  ? 473 VAL A CB  1 
ATOM 3656  C CG1 . VAL A 1 479 ? 46.051  -1.377  -3.492  1.00 69.73  ? 473 VAL A CG1 1 
ATOM 3657  C CG2 . VAL A 1 479 ? 48.330  -0.461  -3.010  1.00 79.93  ? 473 VAL A CG2 1 
ATOM 3658  N N   . THR A 1 480 ? 47.743  -4.821  -3.695  1.00 76.88  ? 474 THR A N   1 
ATOM 3659  C CA  . THR A 1 480 ? 47.156  -6.064  -4.203  1.00 93.31  ? 474 THR A CA  1 
ATOM 3660  C C   . THR A 1 480 ? 47.032  -7.054  -3.070  1.00 83.99  ? 474 THR A C   1 
ATOM 3661  O O   . THR A 1 480 ? 46.012  -7.761  -3.007  1.00 79.59  ? 474 THR A O   1 
ATOM 3662  C CB  . THR A 1 480 ? 48.026  -6.579  -5.342  1.00 102.62 ? 474 THR A CB  1 
ATOM 3663  O OG1 . THR A 1 480 ? 47.721  -5.718  -6.433  1.00 119.11 ? 474 THR A OG1 1 
ATOM 3664  C CG2 . THR A 1 480 ? 47.713  -8.017  -5.712  1.00 93.93  ? 474 THR A CG2 1 
ATOM 3665  N N   . LYS A 1 481 ? 48.030  -7.121  -2.199  1.00 75.56  ? 475 LYS A N   1 
ATOM 3666  C CA  . LYS A 1 481 ? 47.973  -8.146  -1.141  1.00 75.02  ? 475 LYS A CA  1 
ATOM 3667  C C   . LYS A 1 481 ? 46.753  -7.838  -0.298  1.00 72.10  ? 475 LYS A C   1 
ATOM 3668  O O   . LYS A 1 481 ? 46.007  -8.764  0.035   1.00 71.78  ? 475 LYS A O   1 
ATOM 3669  C CB  . LYS A 1 481 ? 49.166  -8.020  -0.199  1.00 82.39  ? 475 LYS A CB  1 
ATOM 3670  C CG  . LYS A 1 481 ? 50.518  -8.248  -0.848  1.00 96.42  ? 475 LYS A CG  1 
ATOM 3671  C CD  . LYS A 1 481 ? 51.693  -8.070  0.104   1.00 106.94 ? 475 LYS A CD  1 
ATOM 3672  C CE  . LYS A 1 481 ? 52.987  -7.888  -0.622  1.00 111.82 ? 475 LYS A CE  1 
ATOM 3673  N NZ  . LYS A 1 481 ? 52.808  -7.996  -2.071  1.00 108.15 ? 475 LYS A NZ  1 
ATOM 3674  N N   . CYS A 1 482 ? 46.538  -6.562  -0.038  1.00 70.06  ? 476 CYS A N   1 
ATOM 3675  C CA  . CYS A 1 482 ? 45.400  -6.155  0.804   1.00 72.69  ? 476 CYS A CA  1 
ATOM 3676  C C   . CYS A 1 482 ? 44.114  -6.361  0.021   1.00 72.55  ? 476 CYS A C   1 
ATOM 3677  O O   . CYS A 1 482 ? 43.077  -6.579  0.646   1.00 67.16  ? 476 CYS A O   1 
ATOM 3678  C CB  . CYS A 1 482 ? 45.506  -4.673  1.124   1.00 75.43  ? 476 CYS A CB  1 
ATOM 3679  S SG  . CYS A 1 482 ? 47.146  -4.152  1.682   1.00 90.79  ? 476 CYS A SG  1 
ATOM 3680  N N   . CYS A 1 483 ? 44.200  -6.376  -1.299  1.00 76.50  ? 477 CYS A N   1 
ATOM 3681  C CA  . CYS A 1 483 ? 42.987  -6.378  -2.102  1.00 80.97  ? 477 CYS A CA  1 
ATOM 3682  C C   . CYS A 1 483 ? 42.407  -7.779  -2.257  1.00 86.33  ? 477 CYS A C   1 
ATOM 3683  O O   . CYS A 1 483 ? 41.304  -7.924  -2.791  1.00 80.52  ? 477 CYS A O   1 
ATOM 3684  C CB  . CYS A 1 483 ? 43.252  -5.766  -3.469  1.00 84.06  ? 477 CYS A CB  1 
ATOM 3685  S SG  . CYS A 1 483 ? 43.555  -3.985  -3.385  1.00 83.45  ? 477 CYS A SG  1 
ATOM 3686  N N   . THR A 1 484 ? 43.155  -8.800  -1.810  1.00 96.84  ? 478 THR A N   1 
ATOM 3687  C CA  . THR A 1 484 ? 42.652  -10.168 -1.835  1.00 95.48  ? 478 THR A CA  1 
ATOM 3688  C C   . THR A 1 484 ? 43.222  -11.018 -0.687  1.00 81.88  ? 478 THR A C   1 
ATOM 3689  O O   . THR A 1 484 ? 43.354  -12.223 -0.847  1.00 75.22  ? 478 THR A O   1 
ATOM 3690  C CB  . THR A 1 484 ? 42.937  -10.765 -3.219  1.00 96.67  ? 478 THR A CB  1 
ATOM 3691  O OG1 . THR A 1 484 ? 44.244  -10.310 -3.558  1.00 102.69 ? 478 THR A OG1 1 
ATOM 3692  C CG2 . THR A 1 484 ? 41.940  -10.339 -4.288  1.00 83.76  ? 478 THR A CG2 1 
ATOM 3693  N N   . GLU A 1 485 ? 43.518  -10.421 0.482   1.00 79.60  ? 479 GLU A N   1 
ATOM 3694  C CA  . GLU A 1 485 ? 43.493  -11.142 1.752   1.00 78.39  ? 479 GLU A CA  1 
ATOM 3695  C C   . GLU A 1 485 ? 42.039  -11.335 2.174   1.00 77.02  ? 479 GLU A C   1 
ATOM 3696  O O   . GLU A 1 485 ? 41.140  -10.810 1.528   1.00 83.14  ? 479 GLU A O   1 
ATOM 3697  C CB  . GLU A 1 485 ? 44.126  -10.385 2.921   1.00 86.52  ? 479 GLU A CB  1 
ATOM 3698  C CG  . GLU A 1 485 ? 45.614  -10.098 2.757   1.00 99.36  ? 479 GLU A CG  1 
ATOM 3699  C CD  . GLU A 1 485 ? 46.472  -11.315 2.475   1.00 102.54 ? 479 GLU A CD  1 
ATOM 3700  O OE1 . GLU A 1 485 ? 45.922  -12.440 2.463   1.00 104.26 ? 479 GLU A OE1 1 
ATOM 3701  O OE2 . GLU A 1 485 ? 47.693  -11.128 2.268   1.00 99.38  ? 479 GLU A OE2 1 
ATOM 3702  N N   . SER A 1 486 ? 41.807  -12.067 3.268   1.00 71.30  ? 480 SER A N   1 
ATOM 3703  C CA  . SER A 1 486 ? 40.476  -12.170 3.849   1.00 76.13  ? 480 SER A CA  1 
ATOM 3704  C C   . SER A 1 486 ? 39.805  -10.795 3.872   1.00 76.98  ? 480 SER A C   1 
ATOM 3705  O O   . SER A 1 486 ? 40.460  -9.800  4.173   1.00 88.99  ? 480 SER A O   1 
ATOM 3706  C CB  . SER A 1 486 ? 40.551  -12.753 5.253   1.00 85.54  ? 480 SER A CB  1 
ATOM 3707  O OG  . SER A 1 486 ? 39.278  -13.141 5.765   1.00 88.28  ? 480 SER A OG  1 
ATOM 3708  N N   . LEU A 1 487 ? 38.496  -10.759 3.583   1.00 71.23  ? 481 LEU A N   1 
ATOM 3709  C CA  . LEU A 1 487 ? 37.696  -9.549  3.673   1.00 70.13  ? 481 LEU A CA  1 
ATOM 3710  C C   . LEU A 1 487 ? 37.925  -8.896  5.035   1.00 70.30  ? 481 LEU A C   1 
ATOM 3711  O O   . LEU A 1 487 ? 38.093  -7.683  5.134   1.00 72.46  ? 481 LEU A O   1 
ATOM 3712  C CB  . LEU A 1 487 ? 36.224  -9.902  3.466   1.00 74.71  ? 481 LEU A CB  1 
ATOM 3713  C CG  . LEU A 1 487 ? 35.331  -8.799  2.885   1.00 85.75  ? 481 LEU A CG  1 
ATOM 3714  C CD1 . LEU A 1 487 ? 35.294  -7.487  3.682   1.00 83.78  ? 481 LEU A CD1 1 
ATOM 3715  C CD2 . LEU A 1 487 ? 35.746  -8.543  1.443   1.00 86.04  ? 481 LEU A CD2 1 
ATOM 3716  N N   . VAL A 1 488 ? 37.991  -9.691  6.088   1.00 70.50  ? 482 VAL A N   1 
ATOM 3717  C CA  . VAL A 1 488 ? 38.090  -9.093  7.448   1.00 75.44  ? 482 VAL A CA  1 
ATOM 3718  C C   . VAL A 1 488 ? 39.441  -8.396  7.602   1.00 69.30  ? 482 VAL A C   1 
ATOM 3719  O O   . VAL A 1 488 ? 39.477  -7.333  8.225   1.00 78.03  ? 482 VAL A O   1 
ATOM 3720  C CB  . VAL A 1 488 ? 37.884  -10.216 8.479   1.00 81.25  ? 482 VAL A CB  1 
ATOM 3721  C CG1 . VAL A 1 488 ? 36.531  -10.893 8.310   1.00 75.10  ? 482 VAL A CG1 1 
ATOM 3722  C CG2 . VAL A 1 488 ? 39.004  -11.245 8.464   1.00 82.74  ? 482 VAL A CG2 1 
ATOM 3723  N N   . ASN A 1 489 ? 40.494  -8.984  7.075   1.00 69.24  ? 483 ASN A N   1 
ATOM 3724  C CA  . ASN A 1 489 ? 41.887  -8.459  7.137   1.00 77.19  ? 483 ASN A CA  1 
ATOM 3725  C C   . ASN A 1 489 ? 42.075  -7.124  6.415   1.00 78.52  ? 483 ASN A C   1 
ATOM 3726  O O   . ASN A 1 489 ? 42.964  -6.383  6.856   1.00 83.44  ? 483 ASN A O   1 
ATOM 3727  C CB  . ASN A 1 489 ? 42.902  -9.522  6.753   1.00 81.65  ? 483 ASN A CB  1 
ATOM 3728  C CG  . ASN A 1 489 ? 43.653  -10.014 7.965   1.00 93.57  ? 483 ASN A CG  1 
ATOM 3729  O OD1 . ASN A 1 489 ? 43.274  -9.694  9.097   1.00 91.50  ? 483 ASN A OD1 1 
ATOM 3730  N ND2 . ASN A 1 489 ? 44.712  -10.782 7.755   1.00 103.32 ? 483 ASN A ND2 1 
ATOM 3731  N N   . ARG A 1 490 ? 41.423  -6.877  5.280   1.00 70.64  ? 484 ARG A N   1 
ATOM 3732  C CA  . ARG A 1 490 ? 41.782  -5.730  4.413   1.00 67.32  ? 484 ARG A CA  1 
ATOM 3733  C C   . ARG A 1 490 ? 41.683  -4.300  4.931   1.00 64.05  ? 484 ARG A C   1 
ATOM 3734  O O   . ARG A 1 490 ? 42.663  -3.581  4.709   1.00 53.14  ? 484 ARG A O   1 
ATOM 3735  C CB  . ARG A 1 490 ? 40.517  -5.607  3.568   1.00 68.40  ? 484 ARG A CB  1 
ATOM 3736  C CG  . ARG A 1 490 ? 40.661  -5.686  2.055   1.00 71.87  ? 484 ARG A CG  1 
ATOM 3737  C CD  . ARG A 1 490 ? 39.694  -4.782  1.308   1.00 79.11  ? 484 ARG A CD  1 
ATOM 3738  N NE  . ARG A 1 490 ? 38.481  -5.474  0.855   1.00 84.74  ? 484 ARG A NE  1 
ATOM 3739  C CZ  . ARG A 1 490 ? 38.278  -5.972  -0.359  1.00 82.80  ? 484 ARG A CZ  1 
ATOM 3740  N NH1 . ARG A 1 490 ? 39.092  -6.891  -0.845  1.00 85.49  ? 484 ARG A NH1 1 
ATOM 3741  N NH2 . ARG A 1 490 ? 37.251  -5.562  -1.078  1.00 75.44  ? 484 ARG A NH2 1 
ATOM 3742  N N   . ARG A 1 491 ? 40.653  -3.900  5.665   1.00 62.96  ? 485 ARG A N   1 
ATOM 3743  C CA  . ARG A 1 491 ? 40.670  -2.486  6.124   1.00 60.09  ? 485 ARG A CA  1 
ATOM 3744  C C   . ARG A 1 491 ? 41.893  -2.334  7.024   1.00 63.53  ? 485 ARG A C   1 
ATOM 3745  O O   . ARG A 1 491 ? 42.607  -1.327  6.909   1.00 58.05  ? 485 ARG A O   1 
ATOM 3746  C CB  . ARG A 1 491 ? 39.434  -2.038  6.907   1.00 54.08  ? 485 ARG A CB  1 
ATOM 3747  C CG  . ARG A 1 491 ? 39.338  -0.537  7.125   1.00 50.95  ? 485 ARG A CG  1 
ATOM 3748  C CD  . ARG A 1 491 ? 39.878  -0.080  8.469   1.00 49.58  ? 485 ARG A CD  1 
ATOM 3749  N NE  . ARG A 1 491 ? 39.742  -1.097  9.516   1.00 54.70  ? 485 ARG A NE  1 
ATOM 3750  C CZ  . ARG A 1 491 ? 40.496  -1.155  10.601  1.00 58.03  ? 485 ARG A CZ  1 
ATOM 3751  N NH1 . ARG A 1 491 ? 41.659  -0.537  10.634  1.00 54.98  ? 485 ARG A NH1 1 
ATOM 3752  N NH2 . ARG A 1 491 ? 40.084  -1.834  11.652  1.00 58.14  ? 485 ARG A NH2 1 
ATOM 3753  N N   . PRO A 1 492 ? 42.189  -3.319  7.886   1.00 71.33  ? 486 PRO A N   1 
ATOM 3754  C CA  . PRO A 1 492 ? 43.389  -3.265  8.690   1.00 79.95  ? 486 PRO A CA  1 
ATOM 3755  C C   . PRO A 1 492 ? 44.636  -3.266  7.840   1.00 81.31  ? 486 PRO A C   1 
ATOM 3756  O O   . PRO A 1 492 ? 45.622  -2.600  8.192   1.00 69.84  ? 486 PRO A O   1 
ATOM 3757  C CB  . PRO A 1 492 ? 43.205  -4.571  9.445   1.00 82.59  ? 486 PRO A CB  1 
ATOM 3758  C CG  . PRO A 1 492 ? 41.744  -4.616  9.739   1.00 80.28  ? 486 PRO A CG  1 
ATOM 3759  C CD  . PRO A 1 492 ? 41.274  -4.362  8.336   1.00 77.86  ? 486 PRO A CD  1 
ATOM 3760  N N   . CYS A 1 493 ? 44.639  -4.059  6.776   1.00 89.48  ? 487 CYS A N   1 
ATOM 3761  C CA  . CYS A 1 493 ? 45.872  -4.172  5.965   1.00 91.40  ? 487 CYS A CA  1 
ATOM 3762  C C   . CYS A 1 493 ? 46.197  -2.802  5.368   1.00 87.90  ? 487 CYS A C   1 
ATOM 3763  O O   . CYS A 1 493 ? 47.377  -2.427  5.360   1.00 95.01  ? 487 CYS A O   1 
ATOM 3764  C CB  . CYS A 1 493 ? 45.692  -5.204  4.864   1.00 91.26  ? 487 CYS A CB  1 
ATOM 3765  S SG  . CYS A 1 493 ? 47.243  -5.997  4.372   1.00 104.46 ? 487 CYS A SG  1 
ATOM 3766  N N   . PHE A 1 494 ? 45.182  -2.082  4.912   1.00 76.73  ? 488 PHE A N   1 
ATOM 3767  C CA  . PHE A 1 494 ? 45.404  -0.742  4.330   1.00 67.60  ? 488 PHE A CA  1 
ATOM 3768  C C   . PHE A 1 494 ? 45.814  0.192   5.423   1.00 61.33  ? 488 PHE A C   1 
ATOM 3769  O O   . PHE A 1 494 ? 46.581  1.122   5.182   1.00 53.62  ? 488 PHE A O   1 
ATOM 3770  C CB  . PHE A 1 494 ? 44.091  -0.257  3.722   1.00 69.85  ? 488 PHE A CB  1 
ATOM 3771  C CG  . PHE A 1 494 ? 43.783  -0.701  2.301   1.00 69.34  ? 488 PHE A CG  1 
ATOM 3772  C CD1 . PHE A 1 494 ? 44.391  -0.088  1.215   1.00 61.64  ? 488 PHE A CD1 1 
ATOM 3773  C CD2 . PHE A 1 494 ? 42.864  -1.711  2.055   1.00 76.69  ? 488 PHE A CD2 1 
ATOM 3774  C CE1 . PHE A 1 494 ? 44.101  -0.490  -0.076  1.00 67.26  ? 488 PHE A CE1 1 
ATOM 3775  C CE2 . PHE A 1 494 ? 42.577  -2.107  0.761   1.00 76.81  ? 488 PHE A CE2 1 
ATOM 3776  C CZ  . PHE A 1 494 ? 43.195  -1.496  -0.299  1.00 73.76  ? 488 PHE A CZ  1 
ATOM 3777  N N   . SER A 1 495 ? 45.282  -0.035  6.619   1.00 69.48  ? 489 SER A N   1 
ATOM 3778  C CA  . SER A 1 495 ? 45.692  0.811   7.727   1.00 69.90  ? 489 SER A CA  1 
ATOM 3779  C C   . SER A 1 495 ? 47.145  0.518   8.082   1.00 70.04  ? 489 SER A C   1 
ATOM 3780  O O   . SER A 1 495 ? 47.829  1.384   8.622   1.00 74.60  ? 489 SER A O   1 
ATOM 3781  C CB  . SER A 1 495 ? 44.797  0.617   8.931   1.00 70.16  ? 489 SER A CB  1 
ATOM 3782  O OG  . SER A 1 495 ? 43.429  0.525   8.552   1.00 67.17  ? 489 SER A OG  1 
ATOM 3783  N N   . ALA A 1 496 ? 47.591  -0.712  7.784   1.00 68.47  ? 490 ALA A N   1 
ATOM 3784  C CA  . ALA A 1 496 ? 48.944  -1.146  8.090   1.00 68.50  ? 490 ALA A CA  1 
ATOM 3785  C C   . ALA A 1 496 ? 49.964  -0.436  7.202   1.00 71.40  ? 490 ALA A C   1 
ATOM 3786  O O   . ALA A 1 496 ? 51.098  -0.242  7.640   1.00 76.02  ? 490 ALA A O   1 
ATOM 3787  C CB  . ALA A 1 496 ? 49.058  -2.650  7.964   1.00 63.88  ? 490 ALA A CB  1 
ATOM 3788  N N   . LEU A 1 497 ? 49.554  -0.048  5.980   1.00 67.53  ? 491 LEU A N   1 
ATOM 3789  C CA  . LEU A 1 497 ? 50.435  0.587   5.004   1.00 66.53  ? 491 LEU A CA  1 
ATOM 3790  C C   . LEU A 1 497 ? 51.184  1.770   5.616   1.00 71.79  ? 491 LEU A C   1 
ATOM 3791  O O   . LEU A 1 497 ? 50.559  2.687   6.147   1.00 66.45  ? 491 LEU A O   1 
ATOM 3792  C CB  . LEU A 1 497 ? 49.648  1.058   3.783   1.00 64.15  ? 491 LEU A CB  1 
ATOM 3793  C CG  . LEU A 1 497 ? 49.119  -0.036  2.855   1.00 66.66  ? 491 LEU A CG  1 
ATOM 3794  C CD1 . LEU A 1 497 ? 48.199  0.535   1.791   1.00 65.48  ? 491 LEU A CD1 1 
ATOM 3795  C CD2 . LEU A 1 497 ? 50.252  -0.793  2.196   1.00 67.81  ? 491 LEU A CD2 1 
ATOM 3796  N N   . GLU A 1 498 ? 52.522  1.750   5.488   1.00 74.56  ? 492 GLU A N   1 
ATOM 3797  C CA  . GLU A 1 498 ? 53.374  2.838   5.938   1.00 80.20  ? 492 GLU A CA  1 
ATOM 3798  C C   . GLU A 1 498 ? 53.769  3.737   4.759   1.00 84.75  ? 492 GLU A C   1 
ATOM 3799  O O   . GLU A 1 498 ? 53.456  3.462   3.598   1.00 87.52  ? 492 GLU A O   1 
ATOM 3800  C CB  . GLU A 1 498 ? 54.575  2.244   6.681   1.00 89.45  ? 492 GLU A CB  1 
ATOM 3801  C CG  . GLU A 1 498 ? 54.230  1.709   8.071   1.00 99.94  ? 492 GLU A CG  1 
ATOM 3802  C CD  . GLU A 1 498 ? 55.362  1.665   9.097   1.00 108.28 ? 492 GLU A CD  1 
ATOM 3803  O OE1 . GLU A 1 498 ? 56.552  1.590   8.711   1.00 104.32 ? 492 GLU A OE1 1 
ATOM 3804  O OE2 . GLU A 1 498 ? 55.044  1.752   10.311  1.00 106.80 ? 492 GLU A OE2 1 
ATOM 3805  N N   . VAL A 1 499 ? 54.460  4.836   5.080   1.00 81.23  ? 493 VAL A N   1 
ATOM 3806  C CA  . VAL A 1 499 ? 54.956  5.775   4.087   1.00 87.49  ? 493 VAL A CA  1 
ATOM 3807  C C   . VAL A 1 499 ? 56.002  5.099   3.193   1.00 87.55  ? 493 VAL A C   1 
ATOM 3808  O O   . VAL A 1 499 ? 56.937  4.488   3.705   1.00 86.99  ? 493 VAL A O   1 
ATOM 3809  C CB  . VAL A 1 499 ? 55.508  7.028   4.802   1.00 90.31  ? 493 VAL A CB  1 
ATOM 3810  C CG1 . VAL A 1 499 ? 54.392  7.789   5.509   1.00 94.92  ? 493 VAL A CG1 1 
ATOM 3811  C CG2 . VAL A 1 499 ? 56.646  6.729   5.779   1.00 85.63  ? 493 VAL A CG2 1 
ATOM 3812  N N   . ASP A 1 500 ? 55.838  5.222   1.861   1.00 90.42  ? 494 ASP A N   1 
ATOM 3813  C CA  . ASP A 1 500 ? 56.713  4.581   0.883   1.00 95.67  ? 494 ASP A CA  1 
ATOM 3814  C C   . ASP A 1 500 ? 58.058  5.306   0.801   1.00 101.69 ? 494 ASP A C   1 
ATOM 3815  O O   . ASP A 1 500 ? 58.110  6.434   0.323   1.00 112.12 ? 494 ASP A O   1 
ATOM 3816  C CB  . ASP A 1 500 ? 56.077  4.562   -0.499  1.00 89.38  ? 494 ASP A CB  1 
ATOM 3817  C CG  . ASP A 1 500 ? 56.843  3.789   -1.566  1.00 89.43  ? 494 ASP A CG  1 
ATOM 3818  O OD1 . ASP A 1 500 ? 58.090  3.750   -1.472  1.00 88.40  ? 494 ASP A OD1 1 
ATOM 3819  O OD2 . ASP A 1 500 ? 56.189  3.257   -2.500  1.00 75.64  ? 494 ASP A OD2 1 
ATOM 3820  N N   . GLU A 1 501 ? 59.149  4.635   1.205   1.00 113.59 ? 495 GLU A N   1 
ATOM 3821  C CA  . GLU A 1 501 ? 60.432  5.302   1.400   1.00 119.41 ? 495 GLU A CA  1 
ATOM 3822  C C   . GLU A 1 501 ? 61.431  4.914   0.309   1.00 113.63 ? 495 GLU A C   1 
ATOM 3823  O O   . GLU A 1 501 ? 62.625  5.170   0.446   1.00 120.55 ? 495 GLU A O   1 
ATOM 3824  C CB  . GLU A 1 501 ? 61.007  5.000   2.787   1.00 127.30 ? 495 GLU A CB  1 
ATOM 3825  C CG  . GLU A 1 501 ? 60.028  5.284   3.923   1.00 124.00 ? 495 GLU A CG  1 
ATOM 3826  C CD  . GLU A 1 501 ? 60.665  5.890   5.158   1.00 119.47 ? 495 GLU A CD  1 
ATOM 3827  O OE1 . GLU A 1 501 ? 61.255  6.981   5.007   1.00 106.91 ? 495 GLU A OE1 1 
ATOM 3828  O OE2 . GLU A 1 501 ? 60.566  5.291   6.252   1.00 117.75 ? 495 GLU A OE2 1 
ATOM 3829  N N   . THR A 1 502 ? 60.938  4.307   -0.774  1.00 103.61 ? 496 THR A N   1 
ATOM 3830  C CA  . THR A 1 502 ? 61.769  4.024   -1.932  1.00 105.53 ? 496 THR A CA  1 
ATOM 3831  C C   . THR A 1 502 ? 61.394  4.958   -3.088  1.00 123.04 ? 496 THR A C   1 
ATOM 3832  O O   . THR A 1 502 ? 62.129  5.051   -4.072  1.00 131.31 ? 496 THR A O   1 
ATOM 3833  C CB  . THR A 1 502 ? 61.632  2.543   -2.291  1.00 99.07  ? 496 THR A CB  1 
ATOM 3834  O OG1 . THR A 1 502 ? 62.664  2.356   -3.253  1.00 107.59 ? 496 THR A OG1 1 
ATOM 3835  C CG2 . THR A 1 502 ? 60.261  2.140   -2.816  1.00 90.86  ? 496 THR A CG2 1 
ATOM 3836  N N   . TYR A 1 503 ? 60.275  5.684   -2.934  1.00 123.39 ? 497 TYR A N   1 
ATOM 3837  C CA  . TYR A 1 503 ? 59.658  6.437   -4.017  1.00 100.89 ? 497 TYR A CA  1 
ATOM 3838  C C   . TYR A 1 503 ? 60.607  7.531   -4.496  1.00 99.28  ? 497 TYR A C   1 
ATOM 3839  O O   . TYR A 1 503 ? 61.055  8.360   -3.706  1.00 100.69 ? 497 TYR A O   1 
ATOM 3840  C CB  . TYR A 1 503 ? 58.327  7.047   -3.561  1.00 86.32  ? 497 TYR A CB  1 
ATOM 3841  C CG  . TYR A 1 503 ? 57.612  7.807   -4.667  1.00 80.77  ? 497 TYR A CG  1 
ATOM 3842  C CD1 . TYR A 1 503 ? 56.902  7.133   -5.659  1.00 74.71  ? 497 TYR A CD1 1 
ATOM 3843  C CD2 . TYR A 1 503 ? 57.675  9.195   -4.736  1.00 79.59  ? 497 TYR A CD2 1 
ATOM 3844  C CE1 . TYR A 1 503 ? 56.272  7.824   -6.683  1.00 73.37  ? 497 TYR A CE1 1 
ATOM 3845  C CE2 . TYR A 1 503 ? 57.044  9.896   -5.753  1.00 76.05  ? 497 TYR A CE2 1 
ATOM 3846  C CZ  . TYR A 1 503 ? 56.340  9.209   -6.726  1.00 75.02  ? 497 TYR A CZ  1 
ATOM 3847  O OH  . TYR A 1 503 ? 55.720  9.920   -7.711  1.00 80.45  ? 497 TYR A OH  1 
ATOM 3848  N N   . VAL A 1 504 ? 60.891  7.528   -5.802  1.00 96.30  ? 498 VAL A N   1 
ATOM 3849  C CA  . VAL A 1 504 ? 61.709  8.569   -6.402  1.00 97.27  ? 498 VAL A CA  1 
ATOM 3850  C C   . VAL A 1 504 ? 60.821  9.778   -6.685  1.00 90.83  ? 498 VAL A C   1 
ATOM 3851  O O   . VAL A 1 504 ? 59.831  9.653   -7.408  1.00 86.48  ? 498 VAL A O   1 
ATOM 3852  C CB  . VAL A 1 504 ? 62.408  8.076   -7.682  1.00 103.39 ? 498 VAL A CB  1 
ATOM 3853  C CG1 . VAL A 1 504 ? 61.438  7.915   -8.858  1.00 93.63  ? 498 VAL A CG1 1 
ATOM 3854  C CG2 . VAL A 1 504 ? 63.593  8.973   -8.035  1.00 103.52 ? 498 VAL A CG2 1 
ATOM 3855  N N   . PRO A 1 505 ? 61.147  10.973  -6.132  1.00 84.36  ? 499 PRO A N   1 
ATOM 3856  C CA  . PRO A 1 505 ? 60.355  12.183  -6.366  1.00 88.35  ? 499 PRO A CA  1 
ATOM 3857  C C   . PRO A 1 505 ? 60.100  12.442  -7.851  1.00 104.67 ? 499 PRO A C   1 
ATOM 3858  O O   . PRO A 1 505 ? 61.034  12.393  -8.649  1.00 122.84 ? 499 PRO A O   1 
ATOM 3859  C CB  . PRO A 1 505 ? 61.211  13.298  -5.738  1.00 77.83  ? 499 PRO A CB  1 
ATOM 3860  C CG  . PRO A 1 505 ? 62.026  12.599  -4.691  1.00 76.30  ? 499 PRO A CG  1 
ATOM 3861  C CD  . PRO A 1 505 ? 62.297  11.217  -5.251  1.00 80.34  ? 499 PRO A CD  1 
ATOM 3862  N N   . LYS A 1 506 ? 58.837  12.724  -8.209  1.00 98.92  ? 500 LYS A N   1 
ATOM 3863  C CA  . LYS A 1 506 ? 58.465  13.038  -9.582  1.00 87.77  ? 500 LYS A CA  1 
ATOM 3864  C C   . LYS A 1 506 ? 59.056  14.393  -9.969  1.00 94.77  ? 500 LYS A C   1 
ATOM 3865  O O   . LYS A 1 506 ? 59.299  15.234  -9.103  1.00 85.68  ? 500 LYS A O   1 
ATOM 3866  C CB  . LYS A 1 506 ? 56.938  13.011  -9.692  1.00 83.06  ? 500 LYS A CB  1 
ATOM 3867  C CG  . LYS A 1 506 ? 56.329  13.231  -11.077 1.00 85.37  ? 500 LYS A CG  1 
ATOM 3868  C CD  . LYS A 1 506 ? 54.810  13.062  -11.139 1.00 87.45  ? 500 LYS A CD  1 
ATOM 3869  C CE  . LYS A 1 506 ? 54.396  11.694  -10.662 1.00 104.22 ? 500 LYS A CE  1 
ATOM 3870  N NZ  . LYS A 1 506 ? 53.002  11.341  -10.937 1.00 107.52 ? 500 LYS A NZ  1 
ATOM 3871  N N   . GLU A 1 507 ? 59.268  14.585  -11.280 1.00 105.60 ? 501 GLU A N   1 
ATOM 3872  C CA  . GLU A 1 507 ? 59.983  15.739  -11.810 1.00 106.20 ? 501 GLU A CA  1 
ATOM 3873  C C   . GLU A 1 507 ? 59.163  17.011  -11.629 1.00 104.56 ? 501 GLU A C   1 
ATOM 3874  O O   . GLU A 1 507 ? 57.942  16.974  -11.773 1.00 108.54 ? 501 GLU A O   1 
ATOM 3875  C CB  . GLU A 1 507 ? 60.247  15.654  -13.315 1.00 109.35 ? 501 GLU A CB  1 
ATOM 3876  C CG  . GLU A 1 507 ? 60.934  14.374  -13.787 1.00 114.84 ? 501 GLU A CG  1 
ATOM 3877  C CD  . GLU A 1 507 ? 61.400  14.407  -15.239 1.00 117.57 ? 501 GLU A CD  1 
ATOM 3878  O OE1 . GLU A 1 507 ? 61.276  15.466  -15.905 1.00 104.10 ? 501 GLU A OE1 1 
ATOM 3879  O OE2 . GLU A 1 507 ? 61.878  13.352  -15.716 1.00 115.05 ? 501 GLU A OE2 1 
ATOM 3880  N N   . PHE A 1 508 ? 59.843  18.139  -11.368 1.00 99.20  ? 502 PHE A N   1 
ATOM 3881  C CA  . PHE A 1 508 ? 59.172  19.431  -11.360 1.00 95.96  ? 502 PHE A CA  1 
ATOM 3882  C C   . PHE A 1 508 ? 58.499  19.610  -12.716 1.00 82.46  ? 502 PHE A C   1 
ATOM 3883  O O   . PHE A 1 508 ? 59.013  19.155  -13.735 1.00 75.64  ? 502 PHE A O   1 
ATOM 3884  C CB  . PHE A 1 508 ? 60.078  20.640  -11.093 1.00 100.15 ? 502 PHE A CB  1 
ATOM 3885  C CG  . PHE A 1 508 ? 59.323  21.962  -11.004 1.00 97.85  ? 502 PHE A CG  1 
ATOM 3886  C CD1 . PHE A 1 508 ? 58.925  22.637  -12.156 1.00 95.53  ? 502 PHE A CD1 1 
ATOM 3887  C CD2 . PHE A 1 508 ? 59.007  22.522  -9.770  1.00 102.65 ? 502 PHE A CD2 1 
ATOM 3888  C CE1 . PHE A 1 508 ? 58.225  23.831  -12.076 1.00 96.79  ? 502 PHE A CE1 1 
ATOM 3889  C CE2 . PHE A 1 508 ? 58.310  23.720  -9.697  1.00 109.87 ? 502 PHE A CE2 1 
ATOM 3890  C CZ  . PHE A 1 508 ? 57.923  24.374  -10.850 1.00 102.52 ? 502 PHE A CZ  1 
ATOM 3891  N N   . ASN A 1 509 ? 57.336  20.260  -12.717 1.00 75.91  ? 503 ASN A N   1 
ATOM 3892  C CA  . ASN A 1 509 ? 56.667  20.546  -13.970 1.00 81.33  ? 503 ASN A CA  1 
ATOM 3893  C C   . ASN A 1 509 ? 55.858  21.827  -13.813 1.00 86.96  ? 503 ASN A C   1 
ATOM 3894  O O   . ASN A 1 509 ? 54.946  21.882  -12.994 1.00 98.58  ? 503 ASN A O   1 
ATOM 3895  C CB  . ASN A 1 509 ? 55.827  19.361  -14.418 1.00 80.48  ? 503 ASN A CB  1 
ATOM 3896  C CG  . ASN A 1 509 ? 55.359  19.543  -15.838 1.00 85.45  ? 503 ASN A CG  1 
ATOM 3897  O OD1 . ASN A 1 509 ? 56.187  19.552  -16.755 1.00 87.98  ? 503 ASN A OD1 1 
ATOM 3898  N ND2 . ASN A 1 509 ? 54.058  19.710  -16.031 1.00 86.95  ? 503 ASN A ND2 1 
ATOM 3899  N N   . ALA A 1 510 ? 56.201  22.840  -14.619 1.00 85.81  ? 504 ALA A N   1 
ATOM 3900  C CA  . ALA A 1 510 ? 55.733  24.199  -14.407 1.00 82.41  ? 504 ALA A CA  1 
ATOM 3901  C C   . ALA A 1 510 ? 54.230  24.310  -14.646 1.00 68.77  ? 504 ALA A C   1 
ATOM 3902  O O   . ALA A 1 510 ? 53.544  24.947  -13.856 1.00 69.27  ? 504 ALA A O   1 
ATOM 3903  C CB  . ALA A 1 510 ? 56.511  25.173  -15.274 1.00 83.85  ? 504 ALA A CB  1 
ATOM 3904  N N   . GLU A 1 511 ? 53.712  23.708  -15.717 1.00 59.19  ? 505 GLU A N   1 
ATOM 3905  C CA  . GLU A 1 511 ? 52.321  23.950  -16.057 1.00 68.38  ? 505 GLU A CA  1 
ATOM 3906  C C   . GLU A 1 511 ? 51.404  23.427  -14.943 1.00 72.37  ? 505 GLU A C   1 
ATOM 3907  O O   . GLU A 1 511 ? 50.331  23.987  -14.729 1.00 78.22  ? 505 GLU A O   1 
ATOM 3908  C CB  . GLU A 1 511 ? 51.965  23.431  -17.452 1.00 73.04  ? 505 GLU A CB  1 
ATOM 3909  C CG  . GLU A 1 511 ? 50.480  23.545  -17.817 1.00 80.52  ? 505 GLU A CG  1 
ATOM 3910  C CD  . GLU A 1 511 ? 49.816  24.921  -17.735 1.00 88.36  ? 505 GLU A CD  1 
ATOM 3911  O OE1 . GLU A 1 511 ? 50.433  25.924  -18.187 1.00 93.06  ? 505 GLU A OE1 1 
ATOM 3912  O OE2 . GLU A 1 511 ? 48.654  24.989  -17.254 1.00 75.59  ? 505 GLU A OE2 1 
ATOM 3913  N N   . THR A 1 512 ? 51.816  22.379  -14.215 1.00 75.00  ? 506 THR A N   1 
ATOM 3914  C CA  . THR A 1 512 ? 50.946  21.775  -13.210 1.00 80.36  ? 506 THR A CA  1 
ATOM 3915  C C   . THR A 1 512 ? 50.948  22.589  -11.911 1.00 76.91  ? 506 THR A C   1 
ATOM 3916  O O   . THR A 1 512 ? 50.031  22.439  -11.105 1.00 71.33  ? 506 THR A O   1 
ATOM 3917  C CB  . THR A 1 512 ? 51.328  20.314  -12.956 1.00 85.40  ? 506 THR A CB  1 
ATOM 3918  O OG1 . THR A 1 512 ? 52.722  20.304  -12.668 1.00 91.52  ? 506 THR A OG1 1 
ATOM 3919  C CG2 . THR A 1 512 ? 51.005  19.408  -14.133 1.00 83.37  ? 506 THR A CG2 1 
ATOM 3920  N N   . PHE A 1 513 ? 51.963  23.443  -11.706 1.00 75.53  ? 507 PHE A N   1 
ATOM 3921  C CA  . PHE A 1 513 ? 51.964  24.407  -10.612 1.00 75.77  ? 507 PHE A CA  1 
ATOM 3922  C C   . PHE A 1 513 ? 51.729  25.834  -11.120 1.00 72.30  ? 507 PHE A C   1 
ATOM 3923  O O   . PHE A 1 513 ? 52.268  26.790  -10.566 1.00 78.13  ? 507 PHE A O   1 
ATOM 3924  C CB  . PHE A 1 513 ? 53.297  24.312  -9.865  1.00 79.86  ? 507 PHE A CB  1 
ATOM 3925  C CG  . PHE A 1 513 ? 53.585  22.958  -9.236  1.00 86.86  ? 507 PHE A CG  1 
ATOM 3926  C CD1 . PHE A 1 513 ? 52.614  22.287  -8.503  1.00 91.62  ? 507 PHE A CD1 1 
ATOM 3927  C CD2 . PHE A 1 513 ? 54.828  22.354  -9.391  1.00 95.55  ? 507 PHE A CD2 1 
ATOM 3928  C CE1 . PHE A 1 513 ? 52.879  21.048  -7.938  1.00 89.91  ? 507 PHE A CE1 1 
ATOM 3929  C CE2 . PHE A 1 513 ? 55.092  21.118  -8.819  1.00 94.61  ? 507 PHE A CE2 1 
ATOM 3930  C CZ  . PHE A 1 513 ? 54.117  20.467  -8.097  1.00 90.60  ? 507 PHE A CZ  1 
ATOM 3931  N N   . THR A 1 514 ? 50.896  25.990  -12.153 1.00 68.17  ? 508 THR A N   1 
ATOM 3932  C CA  . THR A 1 514 ? 50.591  27.298  -12.705 1.00 67.49  ? 508 THR A CA  1 
ATOM 3933  C C   . THR A 1 514 ? 49.085  27.491  -12.650 1.00 68.76  ? 508 THR A C   1 
ATOM 3934  O O   . THR A 1 514 ? 48.344  26.622  -13.098 1.00 67.44  ? 508 THR A O   1 
ATOM 3935  C CB  . THR A 1 514 ? 51.099  27.414  -14.138 1.00 66.21  ? 508 THR A CB  1 
ATOM 3936  O OG1 . THR A 1 514 ? 52.517  27.419  -14.019 1.00 69.85  ? 508 THR A OG1 1 
ATOM 3937  C CG2 . THR A 1 514 ? 50.649  28.700  -14.803 1.00 66.89  ? 508 THR A CG2 1 
ATOM 3938  N N   . PHE A 1 515 ? 48.656  28.636  -12.113 1.00 66.44  ? 509 PHE A N   1 
ATOM 3939  C CA  . PHE A 1 515 ? 47.241  28.896  -11.952 1.00 66.70  ? 509 PHE A CA  1 
ATOM 3940  C C   . PHE A 1 515 ? 46.836  30.075  -12.821 1.00 65.28  ? 509 PHE A C   1 
ATOM 3941  O O   . PHE A 1 515 ? 47.694  30.748  -13.391 1.00 63.58  ? 509 PHE A O   1 
ATOM 3942  C CB  . PHE A 1 515 ? 47.031  29.070  -10.453 1.00 71.45  ? 509 PHE A CB  1 
ATOM 3943  C CG  . PHE A 1 515 ? 47.387  27.793  -9.713  1.00 75.22  ? 509 PHE A CG  1 
ATOM 3944  C CD1 . PHE A 1 515 ? 48.700  27.547  -9.324  1.00 73.75  ? 509 PHE A CD1 1 
ATOM 3945  C CD2 . PHE A 1 515 ? 46.413  26.832  -9.440  1.00 77.20  ? 509 PHE A CD2 1 
ATOM 3946  C CE1 . PHE A 1 515 ? 49.025  26.372  -8.660  1.00 76.95  ? 509 PHE A CE1 1 
ATOM 3947  C CE2 . PHE A 1 515 ? 46.741  25.661  -8.771  1.00 75.22  ? 509 PHE A CE2 1 
ATOM 3948  C CZ  . PHE A 1 515 ? 48.045  25.436  -8.379  1.00 74.79  ? 509 PHE A CZ  1 
ATOM 3949  N N   . HIS A 1 516 ? 45.521  30.282  -12.843 1.00 64.42  ? 510 HIS A N   1 
ATOM 3950  C CA  . HIS A 1 516 ? 44.982  31.315  -13.737 1.00 66.35  ? 510 HIS A CA  1 
ATOM 3951  C C   . HIS A 1 516 ? 43.776  32.034  -13.141 1.00 64.42  ? 510 HIS A C   1 
ATOM 3952  O O   . HIS A 1 516 ? 43.303  31.629  -12.080 1.00 67.84  ? 510 HIS A O   1 
ATOM 3953  C CB  . HIS A 1 516 ? 44.594  30.623  -15.041 1.00 71.88  ? 510 HIS A CB  1 
ATOM 3954  C CG  . HIS A 1 516 ? 45.748  30.094  -15.826 1.00 70.01  ? 510 HIS A CG  1 
ATOM 3955  N ND1 . HIS A 1 516 ? 46.278  28.840  -15.620 1.00 66.49  ? 510 HIS A ND1 1 
ATOM 3956  C CD2 . HIS A 1 516 ? 46.468  30.639  -16.809 1.00 68.90  ? 510 HIS A CD2 1 
ATOM 3957  C CE1 . HIS A 1 516 ? 47.287  28.650  -16.453 1.00 67.54  ? 510 HIS A CE1 1 
ATOM 3958  N NE2 . HIS A 1 516 ? 47.419  29.730  -17.184 1.00 68.31  ? 510 HIS A NE2 1 
ATOM 3959  N N   . ALA A 1 517 ? 43.215  32.967  -13.887 1.00 63.20  ? 511 ALA A N   1 
ATOM 3960  C CA  . ALA A 1 517 ? 42.060  33.812  -13.520 1.00 62.68  ? 511 ALA A CA  1 
ATOM 3961  C C   . ALA A 1 517 ? 40.865  32.908  -13.303 1.00 68.89  ? 511 ALA A C   1 
ATOM 3962  O O   . ALA A 1 517 ? 40.028  33.224  -12.451 1.00 68.16  ? 511 ALA A O   1 
ATOM 3963  C CB  . ALA A 1 517 ? 41.829  34.813  -14.601 1.00 66.04  ? 511 ALA A CB  1 
ATOM 3964  N N   . ASP A 1 518 ? 40.756  31.837  -14.064 1.00 78.08  ? 512 ASP A N   1 
ATOM 3965  C CA  . ASP A 1 518 ? 39.544  30.998  -14.142 1.00 84.80  ? 512 ASP A CA  1 
ATOM 3966  C C   . ASP A 1 518 ? 39.237  30.454  -12.761 1.00 85.10  ? 512 ASP A C   1 
ATOM 3967  O O   . ASP A 1 518 ? 38.050  30.401  -12.420 1.00 82.83  ? 512 ASP A O   1 
ATOM 3968  C CB  . ASP A 1 518 ? 39.814  29.819  -15.058 1.00 88.21  ? 512 ASP A CB  1 
ATOM 3969  C CG  . ASP A 1 518 ? 38.615  28.936  -15.372 1.00 98.54  ? 512 ASP A CG  1 
ATOM 3970  O OD1 . ASP A 1 518 ? 37.507  29.487  -15.540 1.00 103.60 ? 512 ASP A OD1 1 
ATOM 3971  O OD2 . ASP A 1 518 ? 38.804  27.705  -15.450 1.00 107.06 ? 512 ASP A OD2 1 
ATOM 3972  N N   . ILE A 1 519 ? 40.231  30.112  -11.970 1.00 86.60  ? 513 ILE A N   1 
ATOM 3973  C CA  . ILE A 1 519 ? 39.922  29.435  -10.686 1.00 85.37  ? 513 ILE A CA  1 
ATOM 3974  C C   . ILE A 1 519 ? 39.049  30.396  -9.868  1.00 76.72  ? 513 ILE A C   1 
ATOM 3975  O O   . ILE A 1 519 ? 38.153  29.894  -9.183  1.00 86.35  ? 513 ILE A O   1 
ATOM 3976  C CB  . ILE A 1 519 ? 41.205  29.028  -9.948  1.00 90.48  ? 513 ILE A CB  1 
ATOM 3977  C CG1 . ILE A 1 519 ? 41.917  30.221  -9.333  1.00 88.08  ? 513 ILE A CG1 1 
ATOM 3978  C CG2 . ILE A 1 519 ? 42.129  28.244  -10.878 1.00 100.39 ? 513 ILE A CG2 1 
ATOM 3979  C CD1 . ILE A 1 519 ? 43.025  29.833  -8.375  1.00 91.06  ? 513 ILE A CD1 1 
ATOM 3980  N N   . CYS A 1 520 ? 39.282  31.698  -9.879  1.00 62.24  ? 514 CYS A N   1 
ATOM 3981  C CA  . CYS A 1 520 ? 38.417  32.531  -9.012  1.00 58.09  ? 514 CYS A CA  1 
ATOM 3982  C C   . CYS A 1 520 ? 36.940  32.425  -9.454  1.00 58.57  ? 514 CYS A C   1 
ATOM 3983  O O   . CYS A 1 520 ? 36.075  32.382  -8.569  1.00 58.78  ? 514 CYS A O   1 
ATOM 3984  C CB  . CYS A 1 520 ? 38.899  33.977  -9.022  1.00 60.69  ? 514 CYS A CB  1 
ATOM 3985  S SG  . CYS A 1 520 ? 40.610  34.242  -8.480  1.00 69.94  ? 514 CYS A SG  1 
ATOM 3986  N N   . THR A 1 521 ? 36.636  32.431  -10.743 1.00 62.43  ? 515 THR A N   1 
ATOM 3987  C CA  . THR A 1 521 ? 35.248  32.237  -11.250 1.00 66.99  ? 515 THR A CA  1 
ATOM 3988  C C   . THR A 1 521 ? 34.649  30.869  -10.950 1.00 68.51  ? 515 THR A C   1 
ATOM 3989  O O   . THR A 1 521 ? 33.444  30.825  -10.701 1.00 70.74  ? 515 THR A O   1 
ATOM 3990  C CB  . THR A 1 521 ? 35.179  32.573  -12.741 1.00 72.36  ? 515 THR A CB  1 
ATOM 3991  O OG1 . THR A 1 521 ? 35.311  31.339  -13.438 1.00 67.34  ? 515 THR A OG1 1 
ATOM 3992  C CG2 . THR A 1 521 ? 36.279  33.524  -13.172 1.00 75.65  ? 515 THR A CG2 1 
ATOM 3993  N N   . LEU A 1 522 ? 35.406  29.778  -11.052 1.00 69.82  ? 516 LEU A N   1 
ATOM 3994  C CA  . LEU A 1 522 ? 34.859  28.395  -10.941 1.00 76.37  ? 516 LEU A CA  1 
ATOM 3995  C C   . LEU A 1 522 ? 34.023  28.131  -9.679  1.00 84.86  ? 516 LEU A C   1 
ATOM 3996  O O   . LEU A 1 522 ? 34.164  28.899  -8.719  1.00 93.76  ? 516 LEU A O   1 
ATOM 3997  C CB  . LEU A 1 522 ? 36.051  27.449  -11.023 1.00 74.52  ? 516 LEU A CB  1 
ATOM 3998  C CG  . LEU A 1 522 ? 36.654  27.251  -12.413 1.00 78.23  ? 516 LEU A CG  1 
ATOM 3999  C CD1 . LEU A 1 522 ? 37.785  26.247  -12.328 1.00 83.80  ? 516 LEU A CD1 1 
ATOM 4000  C CD2 . LEU A 1 522 ? 35.585  26.773  -13.371 1.00 75.17  ? 516 LEU A CD2 1 
ATOM 4001  N N   . SER A 1 523 ? 33.202  27.064  -9.680  1.00 87.06  ? 517 SER A N   1 
ATOM 4002  C CA  . SER A 1 523 ? 32.376  26.700  -8.537  1.00 84.85  ? 517 SER A CA  1 
ATOM 4003  C C   . SER A 1 523 ? 33.242  26.033  -7.466  1.00 79.62  ? 517 SER A C   1 
ATOM 4004  O O   . SER A 1 523 ? 34.323  25.523  -7.750  1.00 72.54  ? 517 SER A O   1 
ATOM 4005  C CB  . SER A 1 523 ? 31.177  25.848  -8.942  1.00 85.50  ? 517 SER A CB  1 
ATOM 4006  O OG  . SER A 1 523 ? 31.533  24.549  -9.398  1.00 79.45  ? 517 SER A OG  1 
ATOM 4007  N N   . GLU A 1 524 ? 32.768  26.098  -6.216  1.00 84.55  ? 518 GLU A N   1 
ATOM 4008  C CA  . GLU A 1 524 ? 33.476  25.560  -5.064  1.00 86.28  ? 518 GLU A CA  1 
ATOM 4009  C C   . GLU A 1 524 ? 33.978  24.153  -5.382  1.00 83.97  ? 518 GLU A C   1 
ATOM 4010  O O   . GLU A 1 524 ? 35.155  23.856  -5.194  1.00 78.64  ? 518 GLU A O   1 
ATOM 4011  C CB  . GLU A 1 524 ? 32.540  25.589  -3.853  1.00 91.26  ? 518 GLU A CB  1 
ATOM 4012  C CG  . GLU A 1 524 ? 33.250  25.458  -2.506  1.00 98.61  ? 518 GLU A CG  1 
ATOM 4013  C CD  . GLU A 1 524 ? 32.485  25.991  -1.294  1.00 107.48 ? 518 GLU A CD  1 
ATOM 4014  O OE1 . GLU A 1 524 ? 31.319  26.426  -1.432  1.00 114.50 ? 518 GLU A OE1 1 
ATOM 4015  O OE2 . GLU A 1 524 ? 33.063  25.983  -0.185  1.00 109.90 ? 518 GLU A OE2 1 
ATOM 4016  N N   . LYS A 1 525 ? 33.076  23.311  -5.901  1.00 81.60  ? 519 LYS A N   1 
ATOM 4017  C CA  . LYS A 1 525 ? 33.398  21.926  -6.201  1.00 83.57  ? 519 LYS A CA  1 
ATOM 4018  C C   . LYS A 1 525 ? 34.657  21.934  -7.059  1.00 84.18  ? 519 LYS A C   1 
ATOM 4019  O O   . LYS A 1 525 ? 35.709  21.460  -6.626  1.00 81.96  ? 519 LYS A O   1 
ATOM 4020  C CB  . LYS A 1 525 ? 32.254  21.186  -6.912  1.00 90.93  ? 519 LYS A CB  1 
ATOM 4021  C CG  . LYS A 1 525 ? 30.842  21.727  -6.681  1.00 103.83 ? 519 LYS A CG  1 
ATOM 4022  C CD  . LYS A 1 525 ? 30.440  21.827  -5.212  1.00 120.29 ? 519 LYS A CD  1 
ATOM 4023  C CE  . LYS A 1 525 ? 29.275  22.738  -4.966  1.00 127.07 ? 519 LYS A CE  1 
ATOM 4024  N NZ  . LYS A 1 525 ? 28.982  22.882  -3.535  1.00 126.15 ? 519 LYS A NZ  1 
ATOM 4025  N N   . GLU A 1 526 ? 34.531  22.556  -8.244  1.00 84.06  ? 520 GLU A N   1 
ATOM 4026  C CA  . GLU A 1 526 ? 35.564  22.552  -9.270  1.00 80.77  ? 520 GLU A CA  1 
ATOM 4027  C C   . GLU A 1 526 ? 36.860  23.051  -8.641  1.00 73.04  ? 520 GLU A C   1 
ATOM 4028  O O   . GLU A 1 526 ? 37.914  22.433  -8.787  1.00 75.65  ? 520 GLU A O   1 
ATOM 4029  C CB  . GLU A 1 526 ? 35.338  23.474  -10.475 1.00 95.00  ? 520 GLU A CB  1 
ATOM 4030  C CG  . GLU A 1 526 ? 33.894  23.860  -10.800 1.00 103.76 ? 520 GLU A CG  1 
ATOM 4031  C CD  . GLU A 1 526 ? 32.991  22.777  -11.353 1.00 112.64 ? 520 GLU A CD  1 
ATOM 4032  O OE1 . GLU A 1 526 ? 33.499  21.688  -11.723 1.00 115.01 ? 520 GLU A OE1 1 
ATOM 4033  O OE2 . GLU A 1 526 ? 31.768  23.054  -11.404 1.00 112.11 ? 520 GLU A OE2 1 
ATOM 4034  N N   . ARG A 1 527 ? 36.753  24.185  -7.939  1.00 65.23  ? 521 ARG A N   1 
ATOM 4035  C CA  . ARG A 1 527 ? 37.907  24.844  -7.360  1.00 64.30  ? 521 ARG A CA  1 
ATOM 4036  C C   . ARG A 1 527 ? 38.674  23.845  -6.505  1.00 63.19  ? 521 ARG A C   1 
ATOM 4037  O O   . ARG A 1 527 ? 39.871  23.631  -6.699  1.00 67.68  ? 521 ARG A O   1 
ATOM 4038  C CB  . ARG A 1 527 ? 37.478  26.067  -6.543  1.00 64.33  ? 521 ARG A CB  1 
ATOM 4039  C CG  . ARG A 1 527 ? 38.595  26.679  -5.706  1.00 65.32  ? 521 ARG A CG  1 
ATOM 4040  C CD  . ARG A 1 527 ? 38.177  27.999  -5.081  1.00 67.94  ? 521 ARG A CD  1 
ATOM 4041  N NE  . ARG A 1 527 ? 37.462  28.779  -6.096  1.00 68.00  ? 521 ARG A NE  1 
ATOM 4042  C CZ  . ARG A 1 527 ? 36.186  29.139  -6.031  1.00 67.33  ? 521 ARG A CZ  1 
ATOM 4043  N NH1 . ARG A 1 527 ? 35.515  28.959  -4.904  1.00 63.49  ? 521 ARG A NH1 1 
ATOM 4044  N NH2 . ARG A 1 527 ? 35.606  29.708  -7.083  1.00 66.59  ? 521 ARG A NH2 1 
ATOM 4045  N N   . GLN A 1 528 ? 37.959  23.218  -5.575  1.00 56.85  ? 522 GLN A N   1 
ATOM 4046  C CA  . GLN A 1 528 ? 38.606  22.339  -4.626  1.00 57.04  ? 522 GLN A CA  1 
ATOM 4047  C C   . GLN A 1 528 ? 39.427  21.311  -5.395  1.00 55.73  ? 522 GLN A C   1 
ATOM 4048  O O   . GLN A 1 528 ? 40.652  21.224  -5.252  1.00 51.41  ? 522 GLN A O   1 
ATOM 4049  C CB  . GLN A 1 528 ? 37.536  21.730  -3.728  1.00 61.61  ? 522 GLN A CB  1 
ATOM 4050  C CG  . GLN A 1 528 ? 36.886  22.751  -2.805  1.00 64.86  ? 522 GLN A CG  1 
ATOM 4051  C CD  . GLN A 1 528 ? 35.905  22.143  -1.831  1.00 65.23  ? 522 GLN A CD  1 
ATOM 4052  O OE1 . GLN A 1 528 ? 35.623  20.938  -1.857  1.00 65.48  ? 522 GLN A OE1 1 
ATOM 4053  N NE2 . GLN A 1 528 ? 35.388  22.990  -0.953  1.00 64.93  ? 522 GLN A NE2 1 
ATOM 4054  N N   . ILE A 1 529 ? 38.749  20.569  -6.266  1.00 50.57  ? 523 ILE A N   1 
ATOM 4055  C CA  . ILE A 1 529 ? 39.419  19.474  -6.939  1.00 53.83  ? 523 ILE A CA  1 
ATOM 4056  C C   . ILE A 1 529 ? 40.690  20.008  -7.588  1.00 60.38  ? 523 ILE A C   1 
ATOM 4057  O O   . ILE A 1 529 ? 41.704  19.310  -7.608  1.00 57.62  ? 523 ILE A O   1 
ATOM 4058  C CB  . ILE A 1 529 ? 38.506  18.803  -7.972  1.00 53.32  ? 523 ILE A CB  1 
ATOM 4059  C CG1 . ILE A 1 529 ? 37.184  18.352  -7.328  1.00 58.90  ? 523 ILE A CG1 1 
ATOM 4060  C CG2 . ILE A 1 529 ? 39.250  17.658  -8.669  1.00 48.62  ? 523 ILE A CG2 1 
ATOM 4061  C CD1 . ILE A 1 529 ? 35.996  18.311  -8.277  1.00 60.39  ? 523 ILE A CD1 1 
ATOM 4062  N N   . LYS A 1 530 ? 40.620  21.240  -8.119  1.00 62.51  ? 524 LYS A N   1 
ATOM 4063  C CA  . LYS A 1 530 ? 41.764  21.836  -8.790  1.00 65.46  ? 524 LYS A CA  1 
ATOM 4064  C C   . LYS A 1 530 ? 42.884  22.014  -7.764  1.00 59.17  ? 524 LYS A C   1 
ATOM 4065  O O   . LYS A 1 530 ? 44.028  21.632  -8.016  1.00 51.44  ? 524 LYS A O   1 
ATOM 4066  C CB  . LYS A 1 530 ? 41.367  23.133  -9.505  1.00 68.02  ? 524 LYS A CB  1 
ATOM 4067  C CG  . LYS A 1 530 ? 42.124  23.438  -10.804 1.00 82.29  ? 524 LYS A CG  1 
ATOM 4068  C CD  . LYS A 1 530 ? 41.752  22.526  -11.975 1.00 93.85  ? 524 LYS A CD  1 
ATOM 4069  C CE  . LYS A 1 530 ? 42.039  23.070  -13.353 1.00 86.76  ? 524 LYS A CE  1 
ATOM 4070  N NZ  . LYS A 1 530 ? 41.547  22.127  -14.361 1.00 78.56  ? 524 LYS A NZ  1 
ATOM 4071  N N   . LYS A 1 531 ? 42.528  22.542  -6.588  1.00 55.21  ? 525 LYS A N   1 
ATOM 4072  C CA  . LYS A 1 531 ? 43.514  22.856  -5.565  1.00 62.14  ? 525 LYS A CA  1 
ATOM 4073  C C   . LYS A 1 531 ? 44.048  21.574  -4.926  1.00 55.15  ? 525 LYS A C   1 
ATOM 4074  O O   . LYS A 1 531 ? 45.209  21.509  -4.519  1.00 48.49  ? 525 LYS A O   1 
ATOM 4075  C CB  . LYS A 1 531 ? 42.950  23.819  -4.512  1.00 71.85  ? 525 LYS A CB  1 
ATOM 4076  C CG  . LYS A 1 531 ? 42.696  25.248  -4.989  1.00 80.13  ? 525 LYS A CG  1 
ATOM 4077  C CD  . LYS A 1 531 ? 42.418  26.262  -3.881  1.00 80.49  ? 525 LYS A CD  1 
ATOM 4078  C CE  . LYS A 1 531 ? 41.138  25.981  -3.160  1.00 81.31  ? 525 LYS A CE  1 
ATOM 4079  N NZ  . LYS A 1 531 ? 40.684  27.145  -2.393  1.00 83.52  ? 525 LYS A NZ  1 
ATOM 4080  N N   . GLN A 1 532 ? 43.203  20.546  -4.844  1.00 53.10  ? 526 GLN A N   1 
ATOM 4081  C CA  . GLN A 1 532 ? 43.637  19.270  -4.288  1.00 55.69  ? 526 GLN A CA  1 
ATOM 4082  C C   . GLN A 1 532 ? 44.586  18.565  -5.258  1.00 56.48  ? 526 GLN A C   1 
ATOM 4083  O O   . GLN A 1 532 ? 45.642  18.076  -4.841  1.00 53.18  ? 526 GLN A O   1 
ATOM 4084  C CB  . GLN A 1 532 ? 42.414  18.436  -3.910  1.00 53.97  ? 526 GLN A CB  1 
ATOM 4085  C CG  . GLN A 1 532 ? 41.820  18.853  -2.570  1.00 50.38  ? 526 GLN A CG  1 
ATOM 4086  C CD  . GLN A 1 532 ? 40.363  18.501  -2.397  1.00 47.74  ? 526 GLN A CD  1 
ATOM 4087  O OE1 . GLN A 1 532 ? 39.694  17.987  -3.295  1.00 50.63  ? 526 GLN A OE1 1 
ATOM 4088  N NE2 . GLN A 1 532 ? 39.845  18.808  -1.224  1.00 51.12  ? 526 GLN A NE2 1 
ATOM 4089  N N   . THR A 1 533 ? 44.203  18.546  -6.550  1.00 55.71  ? 527 THR A N   1 
ATOM 4090  C CA  . THR A 1 533 ? 45.013  17.963  -7.613  1.00 51.14  ? 527 THR A CA  1 
ATOM 4091  C C   . THR A 1 533 ? 46.432  18.537  -7.553  1.00 48.67  ? 527 THR A C   1 
ATOM 4092  O O   . THR A 1 533 ? 47.425  17.840  -7.748  1.00 38.45  ? 527 THR A O   1 
ATOM 4093  C CB  . THR A 1 533 ? 44.340  18.236  -8.955  1.00 50.19  ? 527 THR A CB  1 
ATOM 4094  O OG1 . THR A 1 533 ? 42.967  17.904  -8.792  1.00 49.35  ? 527 THR A OG1 1 
ATOM 4095  C CG2 . THR A 1 533 ? 44.937  17.421  -10.087 1.00 52.25  ? 527 THR A CG2 1 
ATOM 4096  N N   . ALA A 1 534 ? 46.516  19.833  -7.262  1.00 53.15  ? 528 ALA A N   1 
ATOM 4097  C CA  . ALA A 1 534 ? 47.801  20.467  -7.060  1.00 60.24  ? 528 ALA A CA  1 
ATOM 4098  C C   . ALA A 1 534 ? 48.473  19.881  -5.825  1.00 60.26  ? 528 ALA A C   1 
ATOM 4099  O O   . ALA A 1 534 ? 49.640  19.508  -5.869  1.00 60.94  ? 528 ALA A O   1 
ATOM 4100  C CB  . ALA A 1 534 ? 47.624  21.957  -6.927  1.00 64.41  ? 528 ALA A CB  1 
ATOM 4101  N N   . LEU A 1 535 ? 47.732  19.828  -4.719  1.00 61.29  ? 529 LEU A N   1 
ATOM 4102  C CA  . LEU A 1 535 ? 48.304  19.359  -3.467  1.00 60.22  ? 529 LEU A CA  1 
ATOM 4103  C C   . LEU A 1 535 ? 48.973  18.016  -3.714  1.00 59.31  ? 529 LEU A C   1 
ATOM 4104  O O   . LEU A 1 535 ? 50.126  17.819  -3.325  1.00 57.64  ? 529 LEU A O   1 
ATOM 4105  C CB  . LEU A 1 535 ? 47.264  19.246  -2.355  1.00 56.80  ? 529 LEU A CB  1 
ATOM 4106  C CG  . LEU A 1 535 ? 47.791  18.812  -0.984  1.00 53.48  ? 529 LEU A CG  1 
ATOM 4107  C CD1 . LEU A 1 535 ? 48.918  19.706  -0.469  1.00 51.02  ? 529 LEU A CD1 1 
ATOM 4108  C CD2 . LEU A 1 535 ? 46.622  18.770  -0.002  1.00 53.50  ? 529 LEU A CD2 1 
ATOM 4109  N N   . VAL A 1 536 ? 48.237  17.110  -4.367  1.00 57.27  ? 530 VAL A N   1 
ATOM 4110  C CA  . VAL A 1 536 ? 48.769  15.786  -4.620  1.00 70.69  ? 530 VAL A CA  1 
ATOM 4111  C C   . VAL A 1 536 ? 50.149  15.926  -5.263  1.00 72.28  ? 530 VAL A C   1 
ATOM 4112  O O   . VAL A 1 536 ? 51.157  15.495  -4.697  1.00 67.24  ? 530 VAL A O   1 
ATOM 4113  C CB  . VAL A 1 536 ? 47.812  14.969  -5.505  1.00 77.30  ? 530 VAL A CB  1 
ATOM 4114  C CG1 . VAL A 1 536 ? 48.454  13.672  -5.993  1.00 80.66  ? 530 VAL A CG1 1 
ATOM 4115  C CG2 . VAL A 1 536 ? 46.499  14.693  -4.786  1.00 78.31  ? 530 VAL A CG2 1 
ATOM 4116  N N   . GLU A 1 537 ? 50.162  16.579  -6.434  1.00 65.04  ? 531 GLU A N   1 
ATOM 4117  C CA  . GLU A 1 537 ? 51.339  16.650  -7.278  1.00 59.81  ? 531 GLU A CA  1 
ATOM 4118  C C   . GLU A 1 537 ? 52.499  17.274  -6.511  1.00 61.52  ? 531 GLU A C   1 
ATOM 4119  O O   . GLU A 1 537 ? 53.651  17.036  -6.866  1.00 65.93  ? 531 GLU A O   1 
ATOM 4120  C CB  . GLU A 1 537 ? 51.057  17.461  -8.541  1.00 63.03  ? 531 GLU A CB  1 
ATOM 4121  C CG  . GLU A 1 537 ? 50.069  16.801  -9.497  1.00 62.52  ? 531 GLU A CG  1 
ATOM 4122  C CD  . GLU A 1 537 ? 50.604  15.551  -10.172 1.00 70.15  ? 531 GLU A CD  1 
ATOM 4123  O OE1 . GLU A 1 537 ? 51.830  15.239  -10.154 1.00 67.05  ? 531 GLU A OE1 1 
ATOM 4124  O OE2 . GLU A 1 537 ? 49.722  14.857  -10.720 1.00 80.51  ? 531 GLU A OE2 1 
ATOM 4125  N N   . LEU A 1 538 ? 52.184  18.091  -5.494  1.00 63.90  ? 532 LEU A N   1 
ATOM 4126  C CA  . LEU A 1 538 ? 53.199  18.718  -4.660  1.00 68.63  ? 532 LEU A CA  1 
ATOM 4127  C C   . LEU A 1 538 ? 53.864  17.651  -3.797  1.00 76.41  ? 532 LEU A C   1 
ATOM 4128  O O   . LEU A 1 538 ? 55.089  17.626  -3.650  1.00 74.67  ? 532 LEU A O   1 
ATOM 4129  C CB  . LEU A 1 538 ? 52.622  19.833  -3.788  1.00 66.24  ? 532 LEU A CB  1 
ATOM 4130  C CG  . LEU A 1 538 ? 53.522  20.322  -2.645  1.00 64.48  ? 532 LEU A CG  1 
ATOM 4131  C CD1 . LEU A 1 538 ? 54.788  20.981  -3.168  1.00 62.64  ? 532 LEU A CD1 1 
ATOM 4132  C CD2 . LEU A 1 538 ? 52.772  21.255  -1.716  1.00 63.38  ? 532 LEU A CD2 1 
ATOM 4133  N N   . VAL A 1 539 ? 53.037  16.787  -3.206  1.00 78.42  ? 533 VAL A N   1 
ATOM 4134  C CA  . VAL A 1 539 ? 53.555  15.766  -2.315  1.00 79.62  ? 533 VAL A CA  1 
ATOM 4135  C C   . VAL A 1 539 ? 54.442  14.812  -3.116  1.00 73.45  ? 533 VAL A C   1 
ATOM 4136  O O   . VAL A 1 539 ? 55.502  14.420  -2.643  1.00 68.57  ? 533 VAL A O   1 
ATOM 4137  C CB  . VAL A 1 539 ? 52.443  14.993  -1.590  1.00 79.03  ? 533 VAL A CB  1 
ATOM 4138  C CG1 . VAL A 1 539 ? 53.005  14.288  -0.364  1.00 83.33  ? 533 VAL A CG1 1 
ATOM 4139  C CG2 . VAL A 1 539 ? 51.280  15.898  -1.211  1.00 78.43  ? 533 VAL A CG2 1 
ATOM 4140  N N   . LYS A 1 540 ? 53.998  14.445  -4.326  1.00 64.33  ? 534 LYS A N   1 
ATOM 4141  C CA  . LYS A 1 540 ? 54.740  13.530  -5.174  1.00 62.56  ? 534 LYS A CA  1 
ATOM 4142  C C   . LYS A 1 540 ? 56.133  14.081  -5.475  1.00 74.96  ? 534 LYS A C   1 
ATOM 4143  O O   . LYS A 1 540 ? 57.104  13.320  -5.535  1.00 70.53  ? 534 LYS A O   1 
ATOM 4144  C CB  . LYS A 1 540 ? 53.961  13.243  -6.460  1.00 56.53  ? 534 LYS A CB  1 
ATOM 4145  C CG  . LYS A 1 540 ? 52.720  12.402  -6.251  1.00 58.07  ? 534 LYS A CG  1 
ATOM 4146  C CD  . LYS A 1 540 ? 52.116  11.842  -7.531  1.00 63.63  ? 534 LYS A CD  1 
ATOM 4147  C CE  . LYS A 1 540 ? 50.817  11.141  -7.255  1.00 73.26  ? 534 LYS A CE  1 
ATOM 4148  N NZ  . LYS A 1 540 ? 50.105  10.696  -8.458  1.00 76.40  ? 534 LYS A NZ  1 
ATOM 4149  N N   . HIS A 1 541 ? 56.215  15.407  -5.663  1.00 83.41  ? 535 HIS A N   1 
ATOM 4150  C CA  . HIS A 1 541 ? 57.462  16.069  -6.021  1.00 88.91  ? 535 HIS A CA  1 
ATOM 4151  C C   . HIS A 1 541 ? 58.325  16.271  -4.776  1.00 89.44  ? 535 HIS A C   1 
ATOM 4152  O O   . HIS A 1 541 ? 59.547  16.214  -4.878  1.00 94.57  ? 535 HIS A O   1 
ATOM 4153  C CB  . HIS A 1 541 ? 57.186  17.392  -6.750  1.00 95.64  ? 535 HIS A CB  1 
ATOM 4154  C CG  . HIS A 1 541 ? 58.412  18.148  -7.164  1.00 98.40  ? 535 HIS A CG  1 
ATOM 4155  N ND1 . HIS A 1 541 ? 59.564  17.536  -7.610  1.00 108.37 ? 535 HIS A ND1 1 
ATOM 4156  C CD2 . HIS A 1 541 ? 58.657  19.468  -7.204  1.00 96.71  ? 535 HIS A CD2 1 
ATOM 4157  C CE1 . HIS A 1 541 ? 60.466  18.465  -7.907  1.00 112.16 ? 535 HIS A CE1 1 
ATOM 4158  N NE2 . HIS A 1 541 ? 59.936  19.646  -7.664  1.00 100.43 ? 535 HIS A NE2 1 
ATOM 4159  N N   . LYS A 1 542 ? 57.683  16.532  -3.624  1.00 90.36  ? 536 LYS A N   1 
ATOM 4160  C CA  . LYS A 1 542 ? 58.373  16.731  -2.354  1.00 87.06  ? 536 LYS A CA  1 
ATOM 4161  C C   . LYS A 1 542 ? 57.715  15.860  -1.281  1.00 86.68  ? 536 LYS A C   1 
ATOM 4162  O O   . LYS A 1 542 ? 57.002  16.357  -0.403  1.00 81.47  ? 536 LYS A O   1 
ATOM 4163  C CB  . LYS A 1 542 ? 58.378  18.216  -1.969  1.00 85.84  ? 536 LYS A CB  1 
ATOM 4164  C CG  . LYS A 1 542 ? 59.207  19.132  -2.858  1.00 84.39  ? 536 LYS A CG  1 
ATOM 4165  C CD  . LYS A 1 542 ? 60.704  18.837  -2.844  1.00 87.53  ? 536 LYS A CD  1 
ATOM 4166  C CE  . LYS A 1 542 ? 61.513  19.824  -3.626  1.00 87.65  ? 536 LYS A CE  1 
ATOM 4167  N NZ  . LYS A 1 542 ? 61.181  19.822  -5.052  1.00 89.73  ? 536 LYS A NZ  1 
ATOM 4168  N N   . PRO A 1 543 ? 57.929  14.524  -1.329  1.00 88.91  ? 537 PRO A N   1 
ATOM 4169  C CA  . PRO A 1 543 ? 57.351  13.612  -0.341  1.00 91.14  ? 537 PRO A CA  1 
ATOM 4170  C C   . PRO A 1 543 ? 58.076  13.673  0.998   1.00 99.62  ? 537 PRO A C   1 
ATOM 4171  O O   . PRO A 1 543 ? 57.547  13.205  2.004   1.00 100.98 ? 537 PRO A O   1 
ATOM 4172  C CB  . PRO A 1 543 ? 57.496  12.245  -1.013  1.00 88.42  ? 537 PRO A CB  1 
ATOM 4173  C CG  . PRO A 1 543 ? 58.747  12.382  -1.847  1.00 88.07  ? 537 PRO A CG  1 
ATOM 4174  C CD  . PRO A 1 543 ? 58.724  13.816  -2.346  1.00 89.71  ? 537 PRO A CD  1 
ATOM 4175  N N   . LYS A 1 544 ? 59.281  14.256  0.986   1.00 105.84 ? 538 LYS A N   1 
ATOM 4176  C CA  . LYS A 1 544 ? 60.073  14.440  2.189   1.00 101.03 ? 538 LYS A CA  1 
ATOM 4177  C C   . LYS A 1 544 ? 59.368  15.397  3.155   1.00 97.92  ? 538 LYS A C   1 
ATOM 4178  O O   . LYS A 1 544 ? 59.223  15.065  4.327   1.00 108.29 ? 538 LYS A O   1 
ATOM 4179  C CB  . LYS A 1 544 ? 61.485  14.884  1.791   1.00 106.01 ? 538 LYS A CB  1 
ATOM 4180  C CG  . LYS A 1 544 ? 62.434  15.200  2.944   1.00 115.41 ? 538 LYS A CG  1 
ATOM 4181  C CD  . LYS A 1 544 ? 62.588  16.680  3.296   1.00 119.21 ? 538 LYS A CD  1 
ATOM 4182  C CE  . LYS A 1 544 ? 63.700  17.356  2.546   1.00 117.27 ? 538 LYS A CE  1 
ATOM 4183  N NZ  . LYS A 1 544 ? 63.689  18.805  2.750   1.00 117.74 ? 538 LYS A NZ  1 
ATOM 4184  N N   . ALA A 1 545 ? 58.888  16.552  2.668   1.00 86.62  ? 539 ALA A N   1 
ATOM 4185  C CA  . ALA A 1 545 ? 58.577  17.676  3.543   1.00 85.89  ? 539 ALA A CA  1 
ATOM 4186  C C   . ALA A 1 545 ? 57.601  17.281  4.649   1.00 80.77  ? 539 ALA A C   1 
ATOM 4187  O O   . ALA A 1 545 ? 56.607  16.614  4.380   1.00 75.50  ? 539 ALA A O   1 
ATOM 4188  C CB  . ALA A 1 545 ? 58.033  18.834  2.743   1.00 88.23  ? 539 ALA A CB  1 
ATOM 4189  N N   . THR A 1 546 ? 57.899  17.730  5.879   1.00 79.92  ? 540 THR A N   1 
ATOM 4190  C CA  . THR A 1 546 ? 57.055  17.484  7.039   1.00 90.56  ? 540 THR A CA  1 
ATOM 4191  C C   . THR A 1 546 ? 55.753  18.276  6.913   1.00 89.40  ? 540 THR A C   1 
ATOM 4192  O O   . THR A 1 546 ? 55.701  19.274  6.203   1.00 94.13  ? 540 THR A O   1 
ATOM 4193  C CB  . THR A 1 546 ? 57.804  17.844  8.323   1.00 94.67  ? 540 THR A CB  1 
ATOM 4194  O OG1 . THR A 1 546 ? 56.882  17.578  9.375   1.00 110.36 ? 540 THR A OG1 1 
ATOM 4195  C CG2 . THR A 1 546 ? 58.197  19.306  8.422   1.00 94.17  ? 540 THR A CG2 1 
ATOM 4196  N N   . LYS A 1 547 ? 54.727  17.852  7.661   1.00 84.52  ? 541 LYS A N   1 
ATOM 4197  C CA  . LYS A 1 547 ? 53.385  18.394  7.532   1.00 88.84  ? 541 LYS A CA  1 
ATOM 4198  C C   . LYS A 1 547 ? 53.334  19.865  7.949   1.00 92.00  ? 541 LYS A C   1 
ATOM 4199  O O   . LYS A 1 547 ? 52.343  20.548  7.684   1.00 81.17  ? 541 LYS A O   1 
ATOM 4200  C CB  . LYS A 1 547 ? 52.405  17.573  8.378   1.00 95.55  ? 541 LYS A CB  1 
ATOM 4201  C CG  . LYS A 1 547 ? 50.920  17.839  8.109   1.00 103.86 ? 541 LYS A CG  1 
ATOM 4202  C CD  . LYS A 1 547 ? 50.523  17.780  6.635   1.00 102.62 ? 541 LYS A CD  1 
ATOM 4203  C CE  . LYS A 1 547 ? 49.048  17.649  6.377   1.00 101.05 ? 541 LYS A CE  1 
ATOM 4204  N NZ  . LYS A 1 547 ? 48.296  18.834  6.799   1.00 103.27 ? 541 LYS A NZ  1 
ATOM 4205  N N   . GLU A 1 548 ? 54.398  20.341  8.611   1.00 102.07 ? 542 GLU A N   1 
ATOM 4206  C CA  . GLU A 1 548 ? 54.483  21.723  9.057   1.00 110.94 ? 542 GLU A CA  1 
ATOM 4207  C C   . GLU A 1 548 ? 55.063  22.572  7.931   1.00 100.60 ? 542 GLU A C   1 
ATOM 4208  O O   . GLU A 1 548 ? 54.678  23.726  7.758   1.00 107.07 ? 542 GLU A O   1 
ATOM 4209  C CB  . GLU A 1 548 ? 55.330  21.892  10.322  1.00 119.84 ? 542 GLU A CB  1 
ATOM 4210  C CG  . GLU A 1 548 ? 54.885  21.019  11.494  1.00 124.22 ? 542 GLU A CG  1 
ATOM 4211  C CD  . GLU A 1 548 ? 55.425  19.598  11.471  1.00 134.35 ? 542 GLU A CD  1 
ATOM 4212  O OE1 . GLU A 1 548 ? 56.667  19.469  11.442  1.00 131.76 ? 542 GLU A OE1 1 
ATOM 4213  O OE2 . GLU A 1 548 ? 54.632  18.628  11.475  1.00 144.48 ? 542 GLU A OE2 1 
ATOM 4214  N N   . GLN A 1 549 ? 56.000  21.993  7.180   1.00 89.91  ? 543 GLN A N   1 
ATOM 4215  C CA  . GLN A 1 549 ? 56.496  22.620  5.969   1.00 86.36  ? 543 GLN A CA  1 
ATOM 4216  C C   . GLN A 1 549 ? 55.362  22.734  4.957   1.00 81.74  ? 543 GLN A C   1 
ATOM 4217  O O   . GLN A 1 549 ? 55.250  23.751  4.282   1.00 92.18  ? 543 GLN A O   1 
ATOM 4218  C CB  . GLN A 1 549 ? 57.651  21.821  5.369   1.00 84.12  ? 543 GLN A CB  1 
ATOM 4219  C CG  . GLN A 1 549 ? 58.932  21.881  6.191   1.00 85.23  ? 543 GLN A CG  1 
ATOM 4220  C CD  . GLN A 1 549 ? 60.028  21.019  5.606   1.00 87.64  ? 543 GLN A CD  1 
ATOM 4221  O OE1 . GLN A 1 549 ? 59.828  19.835  5.318   1.00 93.66  ? 543 GLN A OE1 1 
ATOM 4222  N NE2 . GLN A 1 549 ? 61.195  21.607  5.395   1.00 86.24  ? 543 GLN A NE2 1 
ATOM 4223  N N   . LEU A 1 550 ? 54.531  21.686  4.872   1.00 75.25  ? 544 LEU A N   1 
ATOM 4224  C CA  . LEU A 1 550 ? 53.469  21.590  3.883   1.00 72.02  ? 544 LEU A CA  1 
ATOM 4225  C C   . LEU A 1 550 ? 52.233  22.371  4.325   1.00 79.50  ? 544 LEU A C   1 
ATOM 4226  O O   . LEU A 1 550 ? 51.351  22.636  3.506   1.00 88.83  ? 544 LEU A O   1 
ATOM 4227  C CB  . LEU A 1 550 ? 53.087  20.128  3.661   1.00 69.62  ? 544 LEU A CB  1 
ATOM 4228  C CG  . LEU A 1 550 ? 54.139  19.213  3.035   1.00 66.46  ? 544 LEU A CG  1 
ATOM 4229  C CD1 . LEU A 1 550 ? 53.678  17.774  3.164   1.00 65.90  ? 544 LEU A CD1 1 
ATOM 4230  C CD2 . LEU A 1 550 ? 54.383  19.574  1.585   1.00 67.38  ? 544 LEU A CD2 1 
ATOM 4231  N N   . LYS A 1 551 ? 52.118  22.657  5.629   1.00 79.88  ? 545 LYS A N   1 
ATOM 4232  C CA  . LYS A 1 551 ? 51.128  23.613  6.102   1.00 79.31  ? 545 LYS A CA  1 
ATOM 4233  C C   . LYS A 1 551 ? 51.568  25.010  5.666   1.00 82.63  ? 545 LYS A C   1 
ATOM 4234  O O   . LYS A 1 551 ? 50.719  25.830  5.324   1.00 87.06  ? 545 LYS A O   1 
ATOM 4235  C CB  . LYS A 1 551 ? 50.913  23.554  7.619   1.00 81.98  ? 545 LYS A CB  1 
ATOM 4236  C CG  . LYS A 1 551 ? 49.828  24.484  8.158   1.00 87.09  ? 545 LYS A CG  1 
ATOM 4237  C CD  . LYS A 1 551 ? 49.519  24.337  9.647   1.00 96.05  ? 545 LYS A CD  1 
ATOM 4238  C CE  . LYS A 1 551 ? 50.578  24.860  10.577  1.00 100.32 ? 545 LYS A CE  1 
ATOM 4239  N NZ  . LYS A 1 551 ? 50.526  26.314  10.745  1.00 102.53 ? 545 LYS A NZ  1 
ATOM 4240  N N   . ALA A 1 552 ? 52.895  25.254  5.668   1.00 80.03  ? 546 ALA A N   1 
ATOM 4241  C CA  . ALA A 1 552 ? 53.483  26.528  5.264   1.00 73.60  ? 546 ALA A CA  1 
ATOM 4242  C C   . ALA A 1 552 ? 53.116  26.857  3.819   1.00 71.11  ? 546 ALA A C   1 
ATOM 4243  O O   . ALA A 1 552 ? 52.769  27.992  3.509   1.00 77.04  ? 546 ALA A O   1 
ATOM 4244  C CB  . ALA A 1 552 ? 54.991  26.510  5.449   1.00 70.16  ? 546 ALA A CB  1 
ATOM 4245  N N   . VAL A 1 553 ? 53.191  25.855  2.942   1.00 63.66  ? 547 VAL A N   1 
ATOM 4246  C CA  . VAL A 1 553 ? 52.926  26.057  1.532   1.00 65.51  ? 547 VAL A CA  1 
ATOM 4247  C C   . VAL A 1 553 ? 51.429  26.269  1.274   1.00 67.78  ? 547 VAL A C   1 
ATOM 4248  O O   . VAL A 1 553 ? 51.063  27.208  0.574   1.00 66.03  ? 547 VAL A O   1 
ATOM 4249  C CB  . VAL A 1 553 ? 53.500  24.859  0.758   1.00 69.36  ? 547 VAL A CB  1 
ATOM 4250  C CG1 . VAL A 1 553 ? 53.040  24.819  -0.696  1.00 71.68  ? 547 VAL A CG1 1 
ATOM 4251  C CG2 . VAL A 1 553 ? 55.017  24.861  0.833   1.00 70.56  ? 547 VAL A CG2 1 
ATOM 4252  N N   . MET A 1 554 ? 50.557  25.404  1.809   1.00 70.16  ? 548 MET A N   1 
ATOM 4253  C CA  . MET A 1 554 ? 49.124  25.542  1.569   1.00 78.79  ? 548 MET A CA  1 
ATOM 4254  C C   . MET A 1 554 ? 48.616  26.839  2.208   1.00 79.08  ? 548 MET A C   1 
ATOM 4255  O O   . MET A 1 554 ? 47.603  27.380  1.764   1.00 91.03  ? 548 MET A O   1 
ATOM 4256  C CB  . MET A 1 554 ? 48.325  24.310  2.040   1.00 94.17  ? 548 MET A CB  1 
ATOM 4257  C CG  . MET A 1 554 ? 46.766  24.471  2.116   1.00 113.43 ? 548 MET A CG  1 
ATOM 4258  S SD  . MET A 1 554 ? 45.725  24.615  0.634   1.00 108.92 ? 548 MET A SD  1 
ATOM 4259  C CE  . MET A 1 554 ? 44.038  24.865  1.216   1.00 76.84  ? 548 MET A CE  1 
ATOM 4260  N N   . ASP A 1 555 ? 49.313  27.358  3.230   1.00 71.81  ? 549 ASP A N   1 
ATOM 4261  C CA  . ASP A 1 555 ? 48.987  28.670  3.779   1.00 72.63  ? 549 ASP A CA  1 
ATOM 4262  C C   . ASP A 1 555 ? 49.360  29.769  2.776   1.00 65.27  ? 549 ASP A C   1 
ATOM 4263  O O   . ASP A 1 555 ? 48.556  30.649  2.491   1.00 58.90  ? 549 ASP A O   1 
ATOM 4264  C CB  . ASP A 1 555 ? 49.613  28.874  5.154   1.00 80.11  ? 549 ASP A CB  1 
ATOM 4265  C CG  . ASP A 1 555 ? 49.007  28.076  6.308   1.00 90.81  ? 549 ASP A CG  1 
ATOM 4266  O OD1 . ASP A 1 555 ? 48.091  27.258  6.050   1.00 111.91 ? 549 ASP A OD1 1 
ATOM 4267  O OD2 . ASP A 1 555 ? 49.450  28.278  7.468   1.00 80.55  ? 549 ASP A OD2 1 
ATOM 4268  N N   . ASP A 1 556 ? 50.582  29.695  2.230   1.00 63.76  ? 550 ASP A N   1 
ATOM 4269  C CA  . ASP A 1 556 ? 51.080  30.659  1.263   1.00 66.64  ? 550 ASP A CA  1 
ATOM 4270  C C   . ASP A 1 556 ? 50.231  30.610  -0.007  1.00 67.51  ? 550 ASP A C   1 
ATOM 4271  O O   . ASP A 1 556 ? 50.015  31.637  -0.646  1.00 76.93  ? 550 ASP A O   1 
ATOM 4272  C CB  . ASP A 1 556 ? 52.572  30.473  0.993   1.00 71.74  ? 550 ASP A CB  1 
ATOM 4273  C CG  . ASP A 1 556 ? 53.544  30.983  2.064   1.00 80.63  ? 550 ASP A CG  1 
ATOM 4274  O OD1 . ASP A 1 556 ? 53.077  31.441  3.137   1.00 87.77  ? 550 ASP A OD1 1 
ATOM 4275  O OD2 . ASP A 1 556 ? 54.780  30.945  1.823   1.00 69.16  ? 550 ASP A OD2 1 
ATOM 4276  N N   . PHE A 1 557 ? 49.743  29.419  -0.364  1.00 67.15  ? 551 PHE A N   1 
ATOM 4277  C CA  . PHE A 1 557 ? 48.842  29.258  -1.493  1.00 66.61  ? 551 PHE A CA  1 
ATOM 4278  C C   . PHE A 1 557 ? 47.491  29.920  -1.218  1.00 69.70  ? 551 PHE A C   1 
ATOM 4279  O O   . PHE A 1 557 ? 46.945  30.601  -2.081  1.00 73.16  ? 551 PHE A O   1 
ATOM 4280  C CB  . PHE A 1 557 ? 48.622  27.778  -1.799  1.00 64.95  ? 551 PHE A CB  1 
ATOM 4281  C CG  . PHE A 1 557 ? 47.996  27.566  -3.166  1.00 67.38  ? 551 PHE A CG  1 
ATOM 4282  C CD1 . PHE A 1 557 ? 48.766  27.715  -4.310  1.00 75.76  ? 551 PHE A CD1 1 
ATOM 4283  C CD2 . PHE A 1 557 ? 46.652  27.232  -3.303  1.00 66.82  ? 551 PHE A CD2 1 
ATOM 4284  C CE1 . PHE A 1 557 ? 48.205  27.535  -5.562  1.00 82.05  ? 551 PHE A CE1 1 
ATOM 4285  C CE2 . PHE A 1 557 ? 46.096  27.043  -4.556  1.00 71.79  ? 551 PHE A CE2 1 
ATOM 4286  C CZ  . PHE A 1 557 ? 46.873  27.199  -5.683  1.00 79.95  ? 551 PHE A CZ  1 
ATOM 4287  N N   . ALA A 1 558 ? 46.930  29.693  -0.027  1.00 69.82  ? 552 ALA A N   1 
ATOM 4288  C CA  . ALA A 1 558 ? 45.658  30.294  0.341   1.00 65.49  ? 552 ALA A CA  1 
ATOM 4289  C C   . ALA A 1 558 ? 45.715  31.806  0.122   1.00 64.50  ? 552 ALA A C   1 
ATOM 4290  O O   . ALA A 1 558 ? 44.757  32.390  -0.396  1.00 56.32  ? 552 ALA A O   1 
ATOM 4291  C CB  . ALA A 1 558 ? 45.335  29.953  1.780   1.00 67.30  ? 552 ALA A CB  1 
ATOM 4292  N N   . ALA A 1 559 ? 46.855  32.406  0.522   1.00 62.91  ? 553 ALA A N   1 
ATOM 4293  C CA  . ALA A 1 559 ? 47.079  33.847  0.494   1.00 63.75  ? 553 ALA A CA  1 
ATOM 4294  C C   . ALA A 1 559 ? 47.220  34.347  -0.940  1.00 66.60  ? 553 ALA A C   1 
ATOM 4295  O O   . ALA A 1 559 ? 46.703  35.411  -1.287  1.00 65.77  ? 553 ALA A O   1 
ATOM 4296  C CB  . ALA A 1 559 ? 48.319  34.190  1.285   1.00 61.19  ? 553 ALA A CB  1 
ATOM 4297  N N   . PHE A 1 560 ? 47.973  33.573  -1.730  1.00 64.71  ? 554 PHE A N   1 
ATOM 4298  C CA  . PHE A 1 560 ? 48.129  33.772  -3.162  1.00 63.05  ? 554 PHE A CA  1 
ATOM 4299  C C   . PHE A 1 560 ? 46.772  33.821  -3.875  1.00 54.99  ? 554 PHE A C   1 
ATOM 4300  O O   . PHE A 1 560 ? 46.570  34.667  -4.735  1.00 49.59  ? 554 PHE A O   1 
ATOM 4301  C CB  . PHE A 1 560 ? 49.031  32.639  -3.666  1.00 71.76  ? 554 PHE A CB  1 
ATOM 4302  C CG  . PHE A 1 560 ? 49.056  32.488  -5.178  1.00 78.83  ? 554 PHE A CG  1 
ATOM 4303  C CD1 . PHE A 1 560 ? 48.109  31.712  -5.842  1.00 88.75  ? 554 PHE A CD1 1 
ATOM 4304  C CD2 . PHE A 1 560 ? 50.016  33.145  -5.932  1.00 84.17  ? 554 PHE A CD2 1 
ATOM 4305  C CE1 . PHE A 1 560 ? 48.122  31.603  -7.227  1.00 91.03  ? 554 PHE A CE1 1 
ATOM 4306  C CE2 . PHE A 1 560 ? 50.025  33.028  -7.313  1.00 88.77  ? 554 PHE A CE2 1 
ATOM 4307  C CZ  . PHE A 1 560 ? 49.081  32.262  -7.959  1.00 88.60  ? 554 PHE A CZ  1 
ATOM 4308  N N   . VAL A 1 561 ? 45.845  32.908  -3.551  1.00 51.99  ? 555 VAL A N   1 
ATOM 4309  C CA  . VAL A 1 561 ? 44.591  32.820  -4.287  1.00 52.92  ? 555 VAL A CA  1 
ATOM 4310  C C   . VAL A 1 561 ? 43.667  33.979  -3.925  1.00 57.14  ? 555 VAL A C   1 
ATOM 4311  O O   . VAL A 1 561 ? 42.978  34.487  -4.805  1.00 59.03  ? 555 VAL A O   1 
ATOM 4312  C CB  . VAL A 1 561 ? 43.857  31.479  -4.115  1.00 50.82  ? 555 VAL A CB  1 
ATOM 4313  C CG1 . VAL A 1 561 ? 42.433  31.494  -4.671  1.00 46.84  ? 555 VAL A CG1 1 
ATOM 4314  C CG2 . VAL A 1 561 ? 44.657  30.357  -4.755  1.00 54.24  ? 555 VAL A CG2 1 
ATOM 4315  N N   . GLU A 1 562 ? 43.611  34.378  -2.649  1.00 62.18  ? 556 GLU A N   1 
ATOM 4316  C CA  . GLU A 1 562 ? 42.608  35.356  -2.254  1.00 70.42  ? 556 GLU A CA  1 
ATOM 4317  C C   . GLU A 1 562 ? 43.051  36.760  -2.665  1.00 62.29  ? 556 GLU A C   1 
ATOM 4318  O O   . GLU A 1 562 ? 42.213  37.601  -2.975  1.00 59.85  ? 556 GLU A O   1 
ATOM 4319  C CB  . GLU A 1 562 ? 42.229  35.251  -0.778  1.00 78.50  ? 556 GLU A CB  1 
ATOM 4320  C CG  . GLU A 1 562 ? 43.149  36.019  0.159   1.00 87.60  ? 556 GLU A CG  1 
ATOM 4321  C CD  . GLU A 1 562 ? 42.425  36.419  1.424   1.00 99.01  ? 556 GLU A CD  1 
ATOM 4322  O OE1 . GLU A 1 562 ? 41.364  35.815  1.676   1.00 108.48 ? 556 GLU A OE1 1 
ATOM 4323  O OE2 . GLU A 1 562 ? 42.895  37.338  2.128   1.00 113.47 ? 556 GLU A OE2 1 
ATOM 4324  N N   . LYS A 1 563 ? 44.366  37.000  -2.660  1.00 60.74  ? 557 LYS A N   1 
ATOM 4325  C CA  . LYS A 1 563 ? 44.941  38.255  -3.126  1.00 62.84  ? 557 LYS A CA  1 
ATOM 4326  C C   . LYS A 1 563 ? 44.573  38.492  -4.597  1.00 60.16  ? 557 LYS A C   1 
ATOM 4327  O O   . LYS A 1 563 ? 43.959  39.504  -4.959  1.00 52.67  ? 557 LYS A O   1 
ATOM 4328  C CB  . LYS A 1 563 ? 46.463  38.187  -2.914  1.00 63.20  ? 557 LYS A CB  1 
ATOM 4329  C CG  . LYS A 1 563 ? 47.282  39.260  -3.610  1.00 65.97  ? 557 LYS A CG  1 
ATOM 4330  C CD  . LYS A 1 563 ? 48.770  39.191  -3.310  1.00 73.98  ? 557 LYS A CD  1 
ATOM 4331  C CE  . LYS A 1 563 ? 49.479  40.430  -3.761  1.00 83.20  ? 557 LYS A CE  1 
ATOM 4332  N NZ  . LYS A 1 563 ? 50.832  40.482  -3.203  1.00 88.87  ? 557 LYS A NZ  1 
ATOM 4333  N N   . CYS A 1 564 ? 44.957  37.519  -5.429  1.00 53.68  ? 558 CYS A N   1 
ATOM 4334  C CA  . CYS A 1 564 ? 44.841  37.615  -6.862  1.00 49.54  ? 558 CYS A CA  1 
ATOM 4335  C C   . CYS A 1 564 ? 43.381  37.645  -7.277  1.00 53.25  ? 558 CYS A C   1 
ATOM 4336  O O   . CYS A 1 564 ? 43.081  38.193  -8.323  1.00 79.23  ? 558 CYS A O   1 
ATOM 4337  C CB  . CYS A 1 564 ? 45.610  36.481  -7.518  1.00 54.66  ? 558 CYS A CB  1 
ATOM 4338  S SG  . CYS A 1 564 ? 47.399  36.580  -7.226  1.00 64.16  ? 558 CYS A SG  1 
ATOM 4339  N N   . CYS A 1 565 ? 42.478  37.089  -6.469  1.00 57.29  ? 559 CYS A N   1 
ATOM 4340  C CA  . CYS A 1 565 ? 41.051  37.135  -6.767  1.00 68.75  ? 559 CYS A CA  1 
ATOM 4341  C C   . CYS A 1 565 ? 40.467  38.543  -6.579  1.00 77.48  ? 559 CYS A C   1 
ATOM 4342  O O   . CYS A 1 565 ? 39.441  38.874  -7.177  1.00 75.10  ? 559 CYS A O   1 
ATOM 4343  C CB  . CYS A 1 565 ? 40.299  36.101  -5.937  1.00 75.06  ? 559 CYS A CB  1 
ATOM 4344  S SG  . CYS A 1 565 ? 40.694  34.403  -6.428  1.00 80.37  ? 559 CYS A SG  1 
ATOM 4345  N N   . LYS A 1 566 ? 41.111  39.368  -5.739  1.00 83.59  ? 560 LYS A N   1 
ATOM 4346  C CA  . LYS A 1 566 ? 40.665  40.731  -5.483  1.00 85.76  ? 560 LYS A CA  1 
ATOM 4347  C C   . LYS A 1 566 ? 41.371  41.713  -6.415  1.00 83.92  ? 560 LYS A C   1 
ATOM 4348  O O   . LYS A 1 566 ? 40.824  42.781  -6.686  1.00 81.71  ? 560 LYS A O   1 
ATOM 4349  C CB  . LYS A 1 566 ? 40.881  41.108  -4.010  1.00 88.78  ? 560 LYS A CB  1 
ATOM 4350  C CG  . LYS A 1 566 ? 39.904  40.402  -3.075  1.00 93.11  ? 560 LYS A CG  1 
ATOM 4351  C CD  . LYS A 1 566 ? 40.071  40.646  -1.581  1.00 87.15  ? 560 LYS A CD  1 
ATOM 4352  C CE  . LYS A 1 566 ? 39.207  39.707  -0.789  1.00 85.34  ? 560 LYS A CE  1 
ATOM 4353  N NZ  . LYS A 1 566 ? 39.746  39.512  0.560   1.00 84.98  ? 560 LYS A NZ  1 
ATOM 4354  N N   . ALA A 1 567 ? 42.564  41.329  -6.902  1.00 79.88  ? 561 ALA A N   1 
ATOM 4355  C CA  . ALA A 1 567 ? 43.380  42.145  -7.794  1.00 78.35  ? 561 ALA A CA  1 
ATOM 4356  C C   . ALA A 1 567 ? 42.573  42.626  -9.000  1.00 77.71  ? 561 ALA A C   1 
ATOM 4357  O O   . ALA A 1 567 ? 41.573  42.000  -9.366  1.00 86.32  ? 561 ALA A O   1 
ATOM 4358  C CB  . ALA A 1 567 ? 44.593  41.358  -8.242  1.00 76.21  ? 561 ALA A CB  1 
ATOM 4359  N N   . ASP A 1 568 ? 43.024  43.740  -9.607  1.00 65.87  ? 562 ASP A N   1 
ATOM 4360  C CA  . ASP A 1 568 ? 42.271  44.403  -10.664 1.00 66.75  ? 562 ASP A CA  1 
ATOM 4361  C C   . ASP A 1 568 ? 42.540  43.713  -12.003 1.00 64.13  ? 562 ASP A C   1 
ATOM 4362  O O   . ASP A 1 568 ? 41.612  43.533  -12.800 1.00 51.43  ? 562 ASP A O   1 
ATOM 4363  C CB  . ASP A 1 568 ? 42.505  45.908  -10.665 1.00 68.21  ? 562 ASP A CB  1 
ATOM 4364  C CG  . ASP A 1 568 ? 41.497  46.726  -9.861  1.00 70.33  ? 562 ASP A CG  1 
ATOM 4365  O OD1 . ASP A 1 568 ? 40.282  46.576  -10.111 1.00 70.21  ? 562 ASP A OD1 1 
ATOM 4366  O OD2 . ASP A 1 568 ? 41.924  47.517  -8.995  1.00 72.45  ? 562 ASP A OD2 1 
ATOM 4367  N N   . ASP A 1 569 ? 43.816  43.352  -12.227 1.00 63.73  ? 563 ASP A N   1 
ATOM 4368  C CA  . ASP A 1 569 ? 44.220  42.473  -13.312 1.00 62.99  ? 563 ASP A CA  1 
ATOM 4369  C C   . ASP A 1 569 ? 44.504  41.091  -12.741 1.00 63.99  ? 563 ASP A C   1 
ATOM 4370  O O   . ASP A 1 569 ? 45.635  40.804  -12.356 1.00 66.68  ? 563 ASP A O   1 
ATOM 4371  C CB  . ASP A 1 569 ? 45.446  42.993  -14.048 1.00 66.11  ? 563 ASP A CB  1 
ATOM 4372  C CG  . ASP A 1 569 ? 45.864  42.190  -15.277 1.00 72.71  ? 563 ASP A CG  1 
ATOM 4373  O OD1 . ASP A 1 569 ? 45.316  41.090  -15.486 1.00 76.47  ? 563 ASP A OD1 1 
ATOM 4374  O OD2 . ASP A 1 569 ? 46.728  42.673  -16.032 1.00 80.73  ? 563 ASP A OD2 1 
ATOM 4375  N N   . LYS A 1 570 ? 43.469  40.242  -12.712 1.00 66.88  ? 564 LYS A N   1 
ATOM 4376  C CA  . LYS A 1 570 ? 43.568  38.913  -12.124 1.00 58.95  ? 564 LYS A CA  1 
ATOM 4377  C C   . LYS A 1 570 ? 44.798  38.208  -12.686 1.00 54.98  ? 564 LYS A C   1 
ATOM 4378  O O   . LYS A 1 570 ? 45.663  37.770  -11.928 1.00 47.36  ? 564 LYS A O   1 
ATOM 4379  C CB  . LYS A 1 570 ? 42.350  38.043  -12.459 1.00 60.62  ? 564 LYS A CB  1 
ATOM 4380  C CG  . LYS A 1 570 ? 40.986  38.571  -12.056 1.00 65.02  ? 564 LYS A CG  1 
ATOM 4381  C CD  . LYS A 1 570 ? 40.442  38.074  -10.728 1.00 68.54  ? 564 LYS A CD  1 
ATOM 4382  C CE  . LYS A 1 570 ? 39.115  38.704  -10.426 1.00 80.06  ? 564 LYS A CE  1 
ATOM 4383  N NZ  . LYS A 1 570 ? 38.119  38.510  -11.490 1.00 84.15  ? 564 LYS A NZ  1 
ATOM 4384  N N   . GLU A 1 571 ? 44.867  38.135  -14.025 1.00 55.42  ? 565 GLU A N   1 
ATOM 4385  C CA  . GLU A 1 571 ? 45.758  37.204  -14.697 1.00 58.53  ? 565 GLU A CA  1 
ATOM 4386  C C   . GLU A 1 571 ? 47.202  37.618  -14.441 1.00 55.48  ? 565 GLU A C   1 
ATOM 4387  O O   . GLU A 1 571 ? 48.029  36.783  -14.080 1.00 53.16  ? 565 GLU A O   1 
ATOM 4388  C CB  . GLU A 1 571 ? 45.447  37.054  -16.188 1.00 65.57  ? 565 GLU A CB  1 
ATOM 4389  C CG  . GLU A 1 571 ? 46.133  35.853  -16.844 1.00 78.79  ? 565 GLU A CG  1 
ATOM 4390  C CD  . GLU A 1 571 ? 45.815  34.456  -16.306 1.00 85.97  ? 565 GLU A CD  1 
ATOM 4391  O OE1 . GLU A 1 571 ? 44.653  34.001  -16.467 1.00 88.06  ? 565 GLU A OE1 1 
ATOM 4392  O OE2 . GLU A 1 571 ? 46.735  33.812  -15.735 1.00 79.04  ? 565 GLU A OE2 1 
ATOM 4393  N N   . THR A 1 572 ? 47.503  38.908  -14.603 1.00 56.37  ? 566 THR A N   1 
ATOM 4394  C CA  . THR A 1 572 ? 48.855  39.360  -14.327 1.00 58.65  ? 566 THR A CA  1 
ATOM 4395  C C   . THR A 1 572 ? 49.193  39.033  -12.879 1.00 57.77  ? 566 THR A C   1 
ATOM 4396  O O   . THR A 1 572 ? 50.328  38.670  -12.601 1.00 69.07  ? 566 THR A O   1 
ATOM 4397  C CB  . THR A 1 572 ? 49.061  40.842  -14.624 1.00 59.76  ? 566 THR A CB  1 
ATOM 4398  O OG1 . THR A 1 572 ? 49.149  40.877  -16.042 1.00 61.49  ? 566 THR A OG1 1 
ATOM 4399  C CG2 . THR A 1 572 ? 50.372  41.381  -14.077 1.00 61.17  ? 566 THR A CG2 1 
ATOM 4400  N N   . CYS A 1 573 ? 48.225  39.149  -11.967 1.00 55.70  ? 567 CYS A N   1 
ATOM 4401  C CA  . CYS A 1 573 ? 48.514  38.815  -10.581 1.00 66.75  ? 567 CYS A CA  1 
ATOM 4402  C C   . CYS A 1 573 ? 48.844  37.327  -10.450 1.00 67.28  ? 567 CYS A C   1 
ATOM 4403  O O   . CYS A 1 573 ? 49.843  36.980  -9.819  1.00 70.62  ? 567 CYS A O   1 
ATOM 4404  C CB  . CYS A 1 573 ? 47.417  39.233  -9.607  1.00 70.30  ? 567 CYS A CB  1 
ATOM 4405  S SG  . CYS A 1 573 ? 48.030  39.370  -7.901  1.00 79.85  ? 567 CYS A SG  1 
ATOM 4406  N N   . PHE A 1 574 ? 48.026  36.456  -11.059 1.00 60.94  ? 568 PHE A N   1 
ATOM 4407  C CA  . PHE A 1 574 ? 48.269  35.021  -10.990 1.00 59.43  ? 568 PHE A CA  1 
ATOM 4408  C C   . PHE A 1 574 ? 49.640  34.701  -11.571 1.00 58.43  ? 568 PHE A C   1 
ATOM 4409  O O   . PHE A 1 574 ? 50.446  34.040  -10.921 1.00 52.81  ? 568 PHE A O   1 
ATOM 4410  C CB  . PHE A 1 574 ? 47.205  34.190  -11.709 1.00 58.33  ? 568 PHE A CB  1 
ATOM 4411  C CG  . PHE A 1 574 ? 46.001  33.901  -10.827 1.00 58.47  ? 568 PHE A CG  1 
ATOM 4412  C CD1 . PHE A 1 574 ? 46.119  33.042  -9.741  1.00 65.97  ? 568 PHE A CD1 1 
ATOM 4413  C CD2 . PHE A 1 574 ? 44.769  34.485  -11.077 1.00 57.04  ? 568 PHE A CD2 1 
ATOM 4414  C CE1 . PHE A 1 574 ? 45.029  32.770  -8.928  1.00 71.05  ? 568 PHE A CE1 1 
ATOM 4415  C CE2 . PHE A 1 574 ? 43.684  34.215  -10.258 1.00 63.86  ? 568 PHE A CE2 1 
ATOM 4416  C CZ  . PHE A 1 574 ? 43.812  33.359  -9.186  1.00 68.69  ? 568 PHE A CZ  1 
ATOM 4417  N N   . ALA A 1 575 ? 49.876  35.170  -12.801 1.00 63.85  ? 569 ALA A N   1 
ATOM 4418  C CA  . ALA A 1 575 ? 51.134  34.945  -13.492 1.00 62.66  ? 569 ALA A CA  1 
ATOM 4419  C C   . ALA A 1 575 ? 52.308  35.407  -12.627 1.00 61.64  ? 569 ALA A C   1 
ATOM 4420  O O   . ALA A 1 575 ? 53.244  34.640  -12.409 1.00 55.41  ? 569 ALA A O   1 
ATOM 4421  C CB  . ALA A 1 575 ? 51.105  35.643  -14.833 1.00 60.94  ? 569 ALA A CB  1 
ATOM 4422  N N   . GLU A 1 576 ? 52.238  36.649  -12.125 1.00 67.56  ? 570 GLU A N   1 
ATOM 4423  C CA  . GLU A 1 576 ? 53.356  37.286  -11.442 1.00 76.53  ? 570 GLU A CA  1 
ATOM 4424  C C   . GLU A 1 576 ? 53.594  36.622  -10.084 1.00 81.30  ? 570 GLU A C   1 
ATOM 4425  O O   . GLU A 1 576 ? 54.708  36.188  -9.783  1.00 86.45  ? 570 GLU A O   1 
ATOM 4426  C CB  . GLU A 1 576 ? 53.129  38.793  -11.281 1.00 81.80  ? 570 GLU A CB  1 
ATOM 4427  C CG  . GLU A 1 576 ? 53.334  39.597  -12.563 1.00 85.24  ? 570 GLU A CG  1 
ATOM 4428  C CD  . GLU A 1 576 ? 54.789  39.816  -12.951 1.00 100.72 ? 570 GLU A CD  1 
ATOM 4429  O OE1 . GLU A 1 576 ? 55.684  39.325  -12.228 1.00 104.58 ? 570 GLU A OE1 1 
ATOM 4430  O OE2 . GLU A 1 576 ? 55.034  40.487  -13.981 1.00 107.01 ? 570 GLU A OE2 1 
ATOM 4431  N N   . GLU A 1 577 ? 52.538  36.544  -9.265  1.00 76.81  ? 571 GLU A N   1 
ATOM 4432  C CA  . GLU A 1 577 ? 52.648  36.005  -7.916  1.00 79.47  ? 571 GLU A CA  1 
ATOM 4433  C C   . GLU A 1 577 ? 52.974  34.514  -7.951  1.00 73.31  ? 571 GLU A C   1 
ATOM 4434  O O   . GLU A 1 577 ? 53.572  33.994  -7.015  1.00 70.90  ? 571 GLU A O   1 
ATOM 4435  C CB  . GLU A 1 577 ? 51.359  36.199  -7.111  1.00 83.05  ? 571 GLU A CB  1 
ATOM 4436  C CG  . GLU A 1 577 ? 51.063  37.654  -6.766  1.00 81.33  ? 571 GLU A CG  1 
ATOM 4437  C CD  . GLU A 1 577 ? 52.264  38.277  -6.083  1.00 85.28  ? 571 GLU A CD  1 
ATOM 4438  O OE1 . GLU A 1 577 ? 52.583  37.890  -4.930  1.00 71.32  ? 571 GLU A OE1 1 
ATOM 4439  O OE2 . GLU A 1 577 ? 52.919  39.104  -6.760  1.00 96.64  ? 571 GLU A OE2 1 
ATOM 4440  N N   . GLY A 1 578 ? 52.527  33.830  -9.011  1.00 76.78  ? 572 GLY A N   1 
ATOM 4441  C CA  . GLY A 1 578 ? 52.779  32.409  -9.200  1.00 72.48  ? 572 GLY A CA  1 
ATOM 4442  C C   . GLY A 1 578 ? 54.271  32.106  -9.194  1.00 70.85  ? 572 GLY A C   1 
ATOM 4443  O O   . GLY A 1 578 ? 54.698  31.173  -8.519  1.00 63.34  ? 572 GLY A O   1 
ATOM 4444  N N   . LYS A 1 579 ? 55.040  32.928  -9.926  1.00 74.11  ? 573 LYS A N   1 
ATOM 4445  C CA  . LYS A 1 579 ? 56.480  32.758  -10.055 1.00 85.74  ? 573 LYS A CA  1 
ATOM 4446  C C   . LYS A 1 579 ? 57.189  33.130  -8.752  1.00 84.21  ? 573 LYS A C   1 
ATOM 4447  O O   . LYS A 1 579 ? 58.209  32.536  -8.412  1.00 90.20  ? 573 LYS A O   1 
ATOM 4448  C CB  . LYS A 1 579 ? 57.051  33.535  -11.255 1.00 90.95  ? 573 LYS A CB  1 
ATOM 4449  C CG  . LYS A 1 579 ? 57.105  32.749  -12.563 1.00 92.46  ? 573 LYS A CG  1 
ATOM 4450  C CD  . LYS A 1 579 ? 58.043  31.544  -12.504 1.00 97.49  ? 573 LYS A CD  1 
ATOM 4451  C CE  . LYS A 1 579 ? 57.444  30.266  -13.019 1.00 89.85  ? 573 LYS A CE  1 
ATOM 4452  N NZ  . LYS A 1 579 ? 58.289  29.129  -12.635 1.00 89.09  ? 573 LYS A NZ  1 
ATOM 4453  N N   . LYS A 1 580 ? 56.666  34.133  -8.046  1.00 81.82  ? 574 LYS A N   1 
ATOM 4454  C CA  . LYS A 1 580 ? 57.209  34.536  -6.760  1.00 85.63  ? 574 LYS A CA  1 
ATOM 4455  C C   . LYS A 1 580 ? 57.005  33.422  -5.730  1.00 87.34  ? 574 LYS A C   1 
ATOM 4456  O O   . LYS A 1 580 ? 57.877  33.158  -4.899  1.00 93.67  ? 574 LYS A O   1 
ATOM 4457  C CB  . LYS A 1 580 ? 56.495  35.808  -6.291  1.00 92.88  ? 574 LYS A CB  1 
ATOM 4458  C CG  . LYS A 1 580 ? 56.506  36.988  -7.267  1.00 97.14  ? 574 LYS A CG  1 
ATOM 4459  C CD  . LYS A 1 580 ? 56.032  38.321  -6.694  1.00 98.00  ? 574 LYS A CD  1 
ATOM 4460  C CE  . LYS A 1 580 ? 56.766  38.731  -5.452  1.00 104.93 ? 574 LYS A CE  1 
ATOM 4461  N NZ  . LYS A 1 580 ? 58.218  38.547  -5.552  1.00 110.87 ? 574 LYS A NZ  1 
ATOM 4462  N N   . LEU A 1 581 ? 55.826  32.789  -5.786  1.00 87.83  ? 575 LEU A N   1 
ATOM 4463  C CA  . LEU A 1 581 ? 55.439  31.740  -4.854  1.00 81.08  ? 575 LEU A CA  1 
ATOM 4464  C C   . LEU A 1 581 ? 56.320  30.513  -5.081  1.00 75.92  ? 575 LEU A C   1 
ATOM 4465  O O   . LEU A 1 581 ? 56.997  30.070  -4.155  1.00 72.34  ? 575 LEU A O   1 
ATOM 4466  C CB  . LEU A 1 581 ? 53.956  31.431  -5.073  1.00 77.37  ? 575 LEU A CB  1 
ATOM 4467  C CG  . LEU A 1 581 ? 53.296  30.451  -4.101  1.00 72.61  ? 575 LEU A CG  1 
ATOM 4468  C CD1 . LEU A 1 581 ? 53.201  31.056  -2.709  1.00 79.20  ? 575 LEU A CD1 1 
ATOM 4469  C CD2 . LEU A 1 581 ? 51.912  30.036  -4.601  1.00 67.61  ? 575 LEU A CD2 1 
ATOM 4470  N N   . VAL A 1 582 ? 56.323  30.008  -6.325  1.00 64.99  ? 576 VAL A N   1 
ATOM 4471  C CA  . VAL A 1 582 ? 57.030  28.787  -6.662  1.00 64.99  ? 576 VAL A CA  1 
ATOM 4472  C C   . VAL A 1 582 ? 58.516  28.992  -6.380  1.00 71.82  ? 576 VAL A C   1 
ATOM 4473  O O   . VAL A 1 582 ? 59.167  28.122  -5.811  1.00 73.47  ? 576 VAL A O   1 
ATOM 4474  C CB  . VAL A 1 582 ? 56.777  28.338  -8.114  1.00 67.09  ? 576 VAL A CB  1 
ATOM 4475  C CG1 . VAL A 1 582 ? 57.484  29.229  -9.127  1.00 73.94  ? 576 VAL A CG1 1 
ATOM 4476  C CG2 . VAL A 1 582 ? 57.175  26.884  -8.340  1.00 66.91  ? 576 VAL A CG2 1 
ATOM 4477  N N   . ALA A 1 583 ? 59.058  30.150  -6.763  1.00 85.08  ? 577 ALA A N   1 
ATOM 4478  C CA  . ALA A 1 583 ? 60.459  30.442  -6.501  1.00 92.76  ? 577 ALA A CA  1 
ATOM 4479  C C   . ALA A 1 583 ? 60.743  30.208  -5.018  1.00 91.19  ? 577 ALA A C   1 
ATOM 4480  O O   . ALA A 1 583 ? 61.671  29.477  -4.661  1.00 88.72  ? 577 ALA A O   1 
ATOM 4481  C CB  . ALA A 1 583 ? 60.791  31.863  -6.914  1.00 96.13  ? 577 ALA A CB  1 
ATOM 4482  N N   . ALA A 1 584 ? 59.851  30.744  -4.201  1.00 81.53  ? 578 ALA A N   1 
ATOM 4483  C CA  . ALA A 1 584 ? 60.082  30.690  -2.753  1.00 83.10  ? 578 ALA A CA  1 
ATOM 4484  C C   . ALA A 1 584 ? 59.893  29.276  -2.235  1.00 86.61  ? 578 ALA A C   1 
ATOM 4485  O O   . ALA A 1 584 ? 60.713  28.806  -1.434  1.00 88.91  ? 578 ALA A O   1 
ATOM 4486  C CB  . ALA A 1 584 ? 59.097  31.622  -2.128  1.00 83.11  ? 578 ALA A CB  1 
ATOM 4487  N N   . SER A 1 585 ? 58.820  28.627  -2.657  1.00 89.16  ? 579 SER A N   1 
ATOM 4488  C CA  . SER A 1 585 ? 58.512  27.295  -2.086  1.00 87.42  ? 579 SER A CA  1 
ATOM 4489  C C   . SER A 1 585 ? 59.612  26.267  -2.402  1.00 92.86  ? 579 SER A C   1 
ATOM 4490  O O   . SER A 1 585 ? 59.938  25.474  -1.509  1.00 90.99  ? 579 SER A O   1 
ATOM 4491  C CB  . SER A 1 585 ? 57.169  26.853  -2.534  1.00 80.65  ? 579 SER A CB  1 
ATOM 4492  O OG  . SER A 1 585 ? 56.189  27.773  -2.075  1.00 79.67  ? 579 SER A OG  1 
ATOM 4493  N N   . GLN A 1 586 ? 60.163  26.272  -3.613  1.00 101.31 ? 580 GLN A N   1 
ATOM 4494  C CA  . GLN A 1 586 ? 61.278  25.338  -3.911  1.00 104.36 ? 580 GLN A CA  1 
ATOM 4495  C C   . GLN A 1 586 ? 62.482  25.741  -3.056  1.00 106.51 ? 580 GLN A C   1 
ATOM 4496  O O   . GLN A 1 586 ? 63.270  24.851  -2.685  1.00 104.57 ? 580 GLN A O   1 
ATOM 4497  C CB  . GLN A 1 586 ? 61.577  25.289  -5.409  1.00 104.49 ? 580 GLN A CB  1 
ATOM 4498  C CG  . GLN A 1 586 ? 61.708  26.639  -6.098  1.00 104.20 ? 580 GLN A CG  1 
ATOM 4499  C CD  . GLN A 1 586 ? 61.387  26.558  -7.574  1.00 110.29 ? 580 GLN A CD  1 
ATOM 4500  O OE1 . GLN A 1 586 ? 60.967  25.513  -8.080  1.00 108.64 ? 580 GLN A OE1 1 
ATOM 4501  N NE2 . GLN A 1 586 ? 61.588  27.659  -8.281  1.00 117.22 ? 580 GLN A NE2 1 
ATOM 4502  N N   . ALA A 1 587 ? 62.615  27.029  -2.767  1.00 103.75 ? 581 ALA A N   1 
ATOM 4503  C CA  . ALA A 1 587 ? 63.675  27.525  -1.899  1.00 93.26  ? 581 ALA A CA  1 
ATOM 4504  C C   . ALA A 1 587 ? 63.529  26.928  -0.495  1.00 91.97  ? 581 ALA A C   1 
ATOM 4505  O O   . ALA A 1 587 ? 64.469  26.959  0.301   1.00 82.08  ? 581 ALA A O   1 
ATOM 4506  C CB  . ALA A 1 587 ? 63.659  29.043  -1.871  1.00 83.44  ? 581 ALA A CB  1 
ATOM 4507  N N   . ALA A 1 588 ? 62.336  26.387  -0.197  1.00 90.60  ? 582 ALA A N   1 
ATOM 4508  C CA  . ALA A 1 588 ? 62.096  25.635  1.024   1.00 88.68  ? 582 ALA A CA  1 
ATOM 4509  C C   . ALA A 1 588 ? 62.018  24.126  0.751   1.00 94.01  ? 582 ALA A C   1 
ATOM 4510  O O   . ALA A 1 588 ? 61.370  23.400  1.495   1.00 93.72  ? 582 ALA A O   1 
ATOM 4511  C CB  . ALA A 1 588 ? 60.842  26.155  1.693   1.00 80.77  ? 582 ALA A CB  1 
ATOM 4512  N N   . LEU A 1 589 ? 62.683  23.630  -0.299  1.00 95.70  ? 583 LEU A N   1 
ATOM 4513  C CA  . LEU A 1 589 ? 63.201  22.270  -0.256  1.00 106.18 ? 583 LEU A CA  1 
ATOM 4514  C C   . LEU A 1 589 ? 64.294  22.239  0.812   1.00 121.45 ? 583 LEU A C   1 
ATOM 4515  O O   . LEU A 1 589 ? 64.273  21.402  1.713   1.00 121.11 ? 583 LEU A O   1 
ATOM 4516  C CB  . LEU A 1 589 ? 63.781  21.775  -1.583  1.00 112.63 ? 583 LEU A CB  1 
ATOM 4517  C CG  . LEU A 1 589 ? 64.770  20.598  -1.477  1.00 109.26 ? 583 LEU A CG  1 
ATOM 4518  C CD1 . LEU A 1 589 ? 64.077  19.242  -1.545  1.00 104.60 ? 583 LEU A CD1 1 
ATOM 4519  C CD2 . LEU A 1 589 ? 65.905  20.663  -2.493  1.00 102.16 ? 583 LEU A CD2 1 
ATOM 4520  N N   . GLY A 1 590 ? 65.265  23.154  0.674   1.00 126.25 ? 584 GLY A N   1 
ATOM 4521  C CA  . GLY A 1 590 ? 66.475  23.150  1.480   1.00 118.63 ? 584 GLY A CA  1 
ATOM 4522  C C   . GLY A 1 590 ? 67.683  22.717  0.662   1.00 118.28 ? 584 GLY A C   1 
ATOM 4523  O O   . GLY A 1 590 ? 67.503  21.863  -0.243  1.00 101.12 ? 584 GLY A O   1 
ATOM 4524  N N   . GLU B 2 1   ? 8.353   -29.041 16.171  1.00 148.03 ? 1   GLU B N   1 
ATOM 4525  C CA  . GLU B 2 1   ? 8.153   -27.953 17.171  1.00 144.21 ? 1   GLU B CA  1 
ATOM 4526  C C   . GLU B 2 1   ? 9.177   -28.153 18.293  1.00 140.17 ? 1   GLU B C   1 
ATOM 4527  O O   . GLU B 2 1   ? 9.808   -29.209 18.356  1.00 129.52 ? 1   GLU B O   1 
ATOM 4528  C CB  . GLU B 2 1   ? 6.683   -27.829 17.610  1.00 135.45 ? 1   GLU B CB  1 
ATOM 4529  C CG  . GLU B 2 1   ? 5.870   -29.128 17.692  1.00 130.69 ? 1   GLU B CG  1 
ATOM 4530  C CD  . GLU B 2 1   ? 4.826   -29.485 16.626  1.00 115.55 ? 1   GLU B CD  1 
ATOM 4531  O OE1 . GLU B 2 1   ? 5.170   -29.825 15.472  1.00 90.05  ? 1   GLU B OE1 1 
ATOM 4532  O OE2 . GLU B 2 1   ? 3.623   -29.457 16.972  1.00 109.28 ? 1   GLU B OE2 1 
ATOM 4533  N N   . VAL B 2 2   ? 9.369   -27.122 19.135  1.00 129.13 ? 2   VAL B N   1 
ATOM 4534  C CA  . VAL B 2 2   ? 10.259  -27.206 20.292  1.00 108.45 ? 2   VAL B CA  1 
ATOM 4535  C C   . VAL B 2 2   ? 9.457   -27.641 21.525  1.00 86.67  ? 2   VAL B C   1 
ATOM 4536  O O   . VAL B 2 2   ? 8.895   -26.795 22.215  1.00 68.78  ? 2   VAL B O   1 
ATOM 4537  C CB  . VAL B 2 2   ? 10.993  -25.870 20.533  1.00 95.08  ? 2   VAL B CB  1 
ATOM 4538  C CG1 . VAL B 2 2   ? 11.997  -25.960 21.686  1.00 78.17  ? 2   VAL B CG1 1 
ATOM 4539  C CG2 . VAL B 2 2   ? 11.643  -25.358 19.246  1.00 92.41  ? 2   VAL B CG2 1 
ATOM 4540  N N   . GLN B 2 3   ? 9.397   -28.965 21.763  1.00 81.40  ? 3   GLN B N   1 
ATOM 4541  C CA  . GLN B 2 3   ? 8.655   -29.566 22.863  1.00 77.94  ? 3   GLN B CA  1 
ATOM 4542  C C   . GLN B 2 3   ? 9.519   -29.604 24.117  1.00 70.62  ? 3   GLN B C   1 
ATOM 4543  O O   . GLN B 2 3   ? 10.709  -29.905 24.045  1.00 64.24  ? 3   GLN B O   1 
ATOM 4544  C CB  . GLN B 2 3   ? 8.348   -31.056 22.699  1.00 88.43  ? 3   GLN B CB  1 
ATOM 4545  C CG  . GLN B 2 3   ? 7.190   -31.406 21.770  1.00 101.73 ? 3   GLN B CG  1 
ATOM 4546  C CD  . GLN B 2 3   ? 7.553   -31.452 20.303  1.00 116.17 ? 3   GLN B CD  1 
ATOM 4547  O OE1 . GLN B 2 3   ? 6.789   -30.987 19.452  1.00 122.87 ? 3   GLN B OE1 1 
ATOM 4548  N NE2 . GLN B 2 3   ? 8.682   -32.069 19.981  1.00 122.18 ? 3   GLN B NE2 1 
ATOM 4549  N N   . LEU B 2 4   ? 8.891   -29.374 25.271  1.00 62.79  ? 4   LEU B N   1 
ATOM 4550  C CA  . LEU B 2 4   ? 9.536   -29.699 26.531  1.00 65.93  ? 4   LEU B CA  1 
ATOM 4551  C C   . LEU B 2 4   ? 8.733   -30.778 27.270  1.00 66.08  ? 4   LEU B C   1 
ATOM 4552  O O   . LEU B 2 4   ? 7.506   -30.825 27.177  1.00 75.22  ? 4   LEU B O   1 
ATOM 4553  C CB  . LEU B 2 4   ? 9.646   -28.390 27.305  1.00 65.74  ? 4   LEU B CB  1 
ATOM 4554  C CG  . LEU B 2 4   ? 10.489  -27.286 26.656  1.00 61.00  ? 4   LEU B CG  1 
ATOM 4555  C CD1 . LEU B 2 4   ? 10.381  -26.064 27.546  1.00 66.67  ? 4   LEU B CD1 1 
ATOM 4556  C CD2 . LEU B 2 4   ? 11.953  -27.632 26.449  1.00 57.24  ? 4   LEU B CD2 1 
ATOM 4557  N N   . VAL B 2 5   ? 9.431   -31.657 27.999  1.00 59.01  ? 5   VAL B N   1 
ATOM 4558  C CA  . VAL B 2 5   ? 8.805   -32.772 28.700  1.00 59.32  ? 5   VAL B CA  1 
ATOM 4559  C C   . VAL B 2 5   ? 9.436   -32.893 30.075  1.00 60.29  ? 5   VAL B C   1 
ATOM 4560  O O   . VAL B 2 5   ? 10.655  -32.914 30.150  1.00 69.34  ? 5   VAL B O   1 
ATOM 4561  C CB  . VAL B 2 5   ? 9.021   -34.083 27.925  1.00 59.35  ? 5   VAL B CB  1 
ATOM 4562  C CG1 . VAL B 2 5   ? 8.899   -35.313 28.820  1.00 60.00  ? 5   VAL B CG1 1 
ATOM 4563  C CG2 . VAL B 2 5   ? 8.103   -34.168 26.716  1.00 57.09  ? 5   VAL B CG2 1 
ATOM 4564  N N   . GLU B 2 6   ? 8.628   -33.031 31.135  1.00 61.28  ? 6   GLU B N   1 
ATOM 4565  C CA  . GLU B 2 6   ? 9.163   -33.055 32.494  1.00 59.40  ? 6   GLU B CA  1 
ATOM 4566  C C   . GLU B 2 6   ? 8.825   -34.393 33.130  1.00 51.11  ? 6   GLU B C   1 
ATOM 4567  O O   . GLU B 2 6   ? 7.928   -35.071 32.659  1.00 53.57  ? 6   GLU B O   1 
ATOM 4568  C CB  . GLU B 2 6   ? 8.644   -31.949 33.420  1.00 64.43  ? 6   GLU B CB  1 
ATOM 4569  C CG  . GLU B 2 6   ? 8.743   -30.531 32.856  1.00 66.62  ? 6   GLU B CG  1 
ATOM 4570  C CD  . GLU B 2 6   ? 7.458   -30.017 32.229  1.00 66.85  ? 6   GLU B CD  1 
ATOM 4571  O OE1 . GLU B 2 6   ? 6.904   -30.711 31.360  1.00 76.03  ? 6   GLU B OE1 1 
ATOM 4572  O OE2 . GLU B 2 6   ? 7.000   -28.928 32.599  1.00 63.71  ? 6   GLU B OE2 1 
ATOM 4573  N N   . SER B 2 7   ? 9.544   -34.752 34.198  1.00 52.09  ? 7   SER B N   1 
ATOM 4574  C CA  . SER B 2 7   ? 9.333   -36.017 34.891  1.00 51.04  ? 7   SER B CA  1 
ATOM 4575  C C   . SER B 2 7   ? 10.275  -36.135 36.087  1.00 57.49  ? 7   SER B C   1 
ATOM 4576  O O   . SER B 2 7   ? 11.337  -35.500 36.118  1.00 56.73  ? 7   SER B O   1 
ATOM 4577  C CB  . SER B 2 7   ? 9.576   -37.172 33.980  1.00 48.49  ? 7   SER B CB  1 
ATOM 4578  O OG  . SER B 2 7   ? 10.902  -37.056 33.483  1.00 51.03  ? 7   SER B OG  1 
ATOM 4579  N N   . GLY B 2 8   ? 9.903   -37.034 37.012  1.00 59.65  ? 8   GLY B N   1 
ATOM 4580  C CA  . GLY B 2 8   ? 10.663  -37.297 38.223  1.00 57.45  ? 8   GLY B CA  1 
ATOM 4581  C C   . GLY B 2 8   ? 9.834   -37.006 39.470  1.00 60.96  ? 8   GLY B C   1 
ATOM 4582  O O   . GLY B 2 8   ? 10.252  -37.357 40.576  1.00 63.05  ? 8   GLY B O   1 
ATOM 4583  N N   . GLY B 2 9   ? 8.658   -36.384 39.273  1.00 58.46  ? 9   GLY B N   1 
ATOM 4584  C CA  . GLY B 2 9   ? 7.903   -35.770 40.361  1.00 61.01  ? 9   GLY B CA  1 
ATOM 4585  C C   . GLY B 2 9   ? 6.913   -36.742 41.001  1.00 57.74  ? 9   GLY B C   1 
ATOM 4586  O O   . GLY B 2 9   ? 6.406   -37.621 40.319  1.00 57.43  ? 9   GLY B O   1 
ATOM 4587  N N   . GLY B 2 10  ? 6.618   -36.547 42.295  1.00 55.30  ? 10  GLY B N   1 
ATOM 4588  C CA  . GLY B 2 10  ? 5.726   -37.431 43.031  1.00 57.84  ? 10  GLY B CA  1 
ATOM 4589  C C   . GLY B 2 10  ? 5.492   -36.965 44.468  1.00 59.54  ? 10  GLY B C   1 
ATOM 4590  O O   . GLY B 2 10  ? 5.252   -35.784 44.698  1.00 61.50  ? 10  GLY B O   1 
ATOM 4591  N N   . LEU B 2 11  ? 5.533   -37.920 45.413  1.00 60.14  ? 11  LEU B N   1 
ATOM 4592  C CA  . LEU B 2 11  ? 5.457   -37.664 46.845  1.00 59.42  ? 11  LEU B CA  1 
ATOM 4593  C C   . LEU B 2 11  ? 6.797   -38.006 47.486  1.00 58.95  ? 11  LEU B C   1 
ATOM 4594  O O   . LEU B 2 11  ? 7.487   -38.917 47.062  1.00 64.74  ? 11  LEU B O   1 
ATOM 4595  C CB  . LEU B 2 11  ? 4.345   -38.514 47.448  1.00 67.76  ? 11  LEU B CB  1 
ATOM 4596  C CG  . LEU B 2 11  ? 3.962   -38.200 48.898  1.00 86.28  ? 11  LEU B CG  1 
ATOM 4597  C CD1 . LEU B 2 11  ? 2.593   -38.805 49.183  1.00 91.53  ? 11  LEU B CD1 1 
ATOM 4598  C CD2 . LEU B 2 11  ? 4.972   -38.703 49.931  1.00 97.98  ? 11  LEU B CD2 1 
ATOM 4599  N N   . VAL B 2 12  ? 7.187   -37.271 48.519  1.00 65.88  ? 12  VAL B N   1 
ATOM 4600  C CA  . VAL B 2 12  ? 8.487   -37.516 49.115  1.00 67.93  ? 12  VAL B CA  1 
ATOM 4601  C C   . VAL B 2 12  ? 8.512   -36.992 50.546  1.00 69.81  ? 12  VAL B C   1 
ATOM 4602  O O   . VAL B 2 12  ? 7.932   -35.944 50.841  1.00 71.89  ? 12  VAL B O   1 
ATOM 4603  C CB  . VAL B 2 12  ? 9.603   -36.894 48.255  1.00 68.93  ? 12  VAL B CB  1 
ATOM 4604  C CG1 . VAL B 2 12  ? 9.139   -35.645 47.511  1.00 66.94  ? 12  VAL B CG1 1 
ATOM 4605  C CG2 . VAL B 2 12  ? 10.857  -36.610 49.078  1.00 72.73  ? 12  VAL B CG2 1 
ATOM 4606  N N   . GLN B 2 13  ? 9.199   -37.756 51.410  1.00 65.23  ? 13  GLN B N   1 
ATOM 4607  C CA  . GLN B 2 13  ? 9.345   -37.430 52.816  1.00 57.59  ? 13  GLN B CA  1 
ATOM 4608  C C   . GLN B 2 13  ? 10.041  -36.086 52.949  1.00 58.06  ? 13  GLN B C   1 
ATOM 4609  O O   . GLN B 2 13  ? 10.987  -35.819 52.204  1.00 58.04  ? 13  GLN B O   1 
ATOM 4610  C CB  . GLN B 2 13  ? 10.220  -38.425 53.572  1.00 54.66  ? 13  GLN B CB  1 
ATOM 4611  C CG  . GLN B 2 13  ? 9.449   -39.311 54.539  1.00 56.43  ? 13  GLN B CG  1 
ATOM 4612  C CD  . GLN B 2 13  ? 10.283  -40.454 55.076  1.00 58.34  ? 13  GLN B CD  1 
ATOM 4613  O OE1 . GLN B 2 13  ? 11.448  -40.288 55.482  1.00 51.90  ? 13  GLN B OE1 1 
ATOM 4614  N NE2 . GLN B 2 13  ? 9.681   -41.638 55.049  1.00 55.45  ? 13  GLN B NE2 1 
ATOM 4615  N N   . PRO B 2 14  ? 9.596   -35.223 53.897  1.00 50.55  ? 14  PRO B N   1 
ATOM 4616  C CA  . PRO B 2 14  ? 10.350  -34.028 54.265  1.00 43.44  ? 14  PRO B CA  1 
ATOM 4617  C C   . PRO B 2 14  ? 11.763  -34.494 54.577  1.00 43.47  ? 14  PRO B C   1 
ATOM 4618  O O   . PRO B 2 14  ? 11.939  -35.496 55.266  1.00 41.21  ? 14  PRO B O   1 
ATOM 4619  C CB  . PRO B 2 14  ? 9.617   -33.508 55.486  1.00 42.18  ? 14  PRO B CB  1 
ATOM 4620  C CG  . PRO B 2 14  ? 8.208   -33.988 55.300  1.00 43.99  ? 14  PRO B CG  1 
ATOM 4621  C CD  . PRO B 2 14  ? 8.340   -35.350 54.648  1.00 46.27  ? 14  PRO B CD  1 
ATOM 4622  N N   . GLY B 2 15  ? 12.751  -33.785 54.028  1.00 45.41  ? 15  GLY B N   1 
ATOM 4623  C CA  . GLY B 2 15  ? 14.143  -34.088 54.299  1.00 47.79  ? 15  GLY B CA  1 
ATOM 4624  C C   . GLY B 2 15  ? 14.766  -34.872 53.157  1.00 53.08  ? 15  GLY B C   1 
ATOM 4625  O O   . GLY B 2 15  ? 15.986  -34.989 53.103  1.00 65.40  ? 15  GLY B O   1 
ATOM 4626  N N   . GLY B 2 16  ? 13.922  -35.372 52.242  1.00 55.74  ? 16  GLY B N   1 
ATOM 4627  C CA  . GLY B 2 16  ? 14.352  -36.300 51.204  1.00 56.28  ? 16  GLY B CA  1 
ATOM 4628  C C   . GLY B 2 16  ? 14.796  -35.575 49.935  1.00 56.81  ? 16  GLY B C   1 
ATOM 4629  O O   . GLY B 2 16  ? 15.088  -34.380 49.969  1.00 54.51  ? 16  GLY B O   1 
ATOM 4630  N N   . SER B 2 17  ? 14.815  -36.324 48.822  1.00 53.99  ? 17  SER B N   1 
ATOM 4631  C CA  . SER B 2 17  ? 15.356  -35.861 47.556  1.00 49.21  ? 17  SER B CA  1 
ATOM 4632  C C   . SER B 2 17  ? 14.444  -36.232 46.388  1.00 54.60  ? 17  SER B C   1 
ATOM 4633  O O   . SER B 2 17  ? 13.626  -37.146 46.470  1.00 53.57  ? 17  SER B O   1 
ATOM 4634  C CB  . SER B 2 17  ? 16.723  -36.422 47.328  1.00 46.31  ? 17  SER B CB  1 
ATOM 4635  O OG  . SER B 2 17  ? 17.634  -35.821 48.225  1.00 49.40  ? 17  SER B OG  1 
ATOM 4636  N N   . LEU B 2 18  ? 14.637  -35.501 45.288  1.00 55.63  ? 18  LEU B N   1 
ATOM 4637  C CA  . LEU B 2 18  ? 14.007  -35.753 44.006  1.00 55.41  ? 18  LEU B CA  1 
ATOM 4638  C C   . LEU B 2 18  ? 14.894  -35.123 42.942  1.00 54.85  ? 18  LEU B C   1 
ATOM 4639  O O   . LEU B 2 18  ? 15.465  -34.063 43.179  1.00 53.42  ? 18  LEU B O   1 
ATOM 4640  C CB  . LEU B 2 18  ? 12.611  -35.136 43.926  1.00 62.29  ? 18  LEU B CB  1 
ATOM 4641  C CG  . LEU B 2 18  ? 11.420  -36.060 44.184  1.00 68.95  ? 18  LEU B CG  1 
ATOM 4642  C CD1 . LEU B 2 18  ? 10.134  -35.261 44.036  1.00 74.84  ? 18  LEU B CD1 1 
ATOM 4643  C CD2 . LEU B 2 18  ? 11.407  -37.263 43.253  1.00 69.81  ? 18  LEU B CD2 1 
ATOM 4644  N N   . ARG B 2 19  ? 14.972  -35.752 41.765  1.00 57.98  ? 19  ARG B N   1 
ATOM 4645  C CA  . ARG B 2 19  ? 15.685  -35.173 40.636  1.00 56.74  ? 19  ARG B CA  1 
ATOM 4646  C C   . ARG B 2 19  ? 14.725  -35.105 39.466  1.00 56.45  ? 19  ARG B C   1 
ATOM 4647  O O   . ARG B 2 19  ? 14.317  -36.137 38.936  1.00 59.85  ? 19  ARG B O   1 
ATOM 4648  C CB  . ARG B 2 19  ? 16.964  -35.933 40.272  1.00 58.00  ? 19  ARG B CB  1 
ATOM 4649  C CG  . ARG B 2 19  ? 17.646  -35.550 38.968  1.00 61.15  ? 19  ARG B CG  1 
ATOM 4650  C CD  . ARG B 2 19  ? 19.009  -36.245 38.819  1.00 71.52  ? 19  ARG B CD  1 
ATOM 4651  N NE  . ARG B 2 19  ? 19.111  -37.067 37.600  1.00 85.78  ? 19  ARG B NE  1 
ATOM 4652  C CZ  . ARG B 2 19  ? 20.229  -37.508 37.014  1.00 86.83  ? 19  ARG B CZ  1 
ATOM 4653  N NH1 . ARG B 2 19  ? 21.392  -36.940 37.284  1.00 96.27  ? 19  ARG B NH1 1 
ATOM 4654  N NH2 . ARG B 2 19  ? 20.171  -38.471 36.106  1.00 77.70  ? 19  ARG B NH2 1 
ATOM 4655  N N   . LEU B 2 20  ? 14.335  -33.874 39.127  1.00 58.96  ? 20  LEU B N   1 
ATOM 4656  C CA  . LEU B 2 20  ? 13.459  -33.637 37.995  1.00 63.81  ? 20  LEU B CA  1 
ATOM 4657  C C   . LEU B 2 20  ? 14.297  -33.704 36.727  1.00 67.88  ? 20  LEU B C   1 
ATOM 4658  O O   . LEU B 2 20  ? 15.484  -33.366 36.754  1.00 72.47  ? 20  LEU B O   1 
ATOM 4659  C CB  . LEU B 2 20  ? 12.747  -32.292 38.115  1.00 66.40  ? 20  LEU B CB  1 
ATOM 4660  C CG  . LEU B 2 20  ? 11.415  -32.295 38.869  1.00 67.79  ? 20  LEU B CG  1 
ATOM 4661  C CD1 . LEU B 2 20  ? 11.514  -33.107 40.148  1.00 72.92  ? 20  LEU B CD1 1 
ATOM 4662  C CD2 . LEU B 2 20  ? 10.987  -30.866 39.171  1.00 68.57  ? 20  LEU B CD2 1 
ATOM 4663  N N   . SER B 2 21  ? 13.660  -34.144 35.633  1.00 63.34  ? 21  SER B N   1 
ATOM 4664  C CA  . SER B 2 21  ? 14.277  -34.069 34.321  1.00 56.93  ? 21  SER B CA  1 
ATOM 4665  C C   . SER B 2 21  ? 13.307  -33.488 33.306  1.00 50.79  ? 21  SER B C   1 
ATOM 4666  O O   . SER B 2 21  ? 12.110  -33.748 33.349  1.00 45.12  ? 21  SER B O   1 
ATOM 4667  C CB  . SER B 2 21  ? 14.798  -35.382 33.899  1.00 57.22  ? 21  SER B CB  1 
ATOM 4668  O OG  . SER B 2 21  ? 15.784  -35.777 34.841  1.00 66.46  ? 21  SER B OG  1 
ATOM 4669  N N   . CYS B 2 22  ? 13.869  -32.654 32.432  1.00 52.71  ? 22  CYS B N   1 
ATOM 4670  C CA  . CYS B 2 22  ? 13.166  -32.127 31.284  1.00 55.63  ? 22  CYS B CA  1 
ATOM 4671  C C   . CYS B 2 22  ? 13.947  -32.504 30.035  1.00 54.44  ? 22  CYS B C   1 
ATOM 4672  O O   . CYS B 2 22  ? 15.150  -32.254 29.992  1.00 50.17  ? 22  CYS B O   1 
ATOM 4673  C CB  . CYS B 2 22  ? 13.017  -30.616 31.360  1.00 60.99  ? 22  CYS B CB  1 
ATOM 4674  S SG  . CYS B 2 22  ? 12.012  -29.951 30.008  1.00 66.83  ? 22  CYS B SG  1 
ATOM 4675  N N   . THR B 2 23  ? 13.255  -33.176 29.115  1.00 61.02  ? 23  THR B N   1 
ATOM 4676  C CA  . THR B 2 23  ? 13.838  -33.587 27.831  1.00 64.02  ? 23  THR B CA  1 
ATOM 4677  C C   . THR B 2 23  ? 13.374  -32.595 26.806  1.00 64.22  ? 23  THR B C   1 
ATOM 4678  O O   . THR B 2 23  ? 12.184  -32.259 26.818  1.00 68.60  ? 23  THR B O   1 
ATOM 4679  C CB  . THR B 2 23  ? 13.389  -35.004 27.505  1.00 63.84  ? 23  THR B CB  1 
ATOM 4680  O OG1 . THR B 2 23  ? 13.840  -35.785 28.606  1.00 61.76  ? 23  THR B OG1 1 
ATOM 4681  C CG2 . THR B 2 23  ? 13.991  -35.519 26.212  1.00 64.43  ? 23  THR B CG2 1 
ATOM 4682  N N   . ALA B 2 24  ? 14.261  -32.180 25.912  1.00 62.54  ? 24  ALA B N   1 
ATOM 4683  C CA  . ALA B 2 24  ? 13.936  -31.090 24.973  1.00 64.95  ? 24  ALA B CA  1 
ATOM 4684  C C   . ALA B 2 24  ? 13.953  -31.572 23.527  1.00 62.86  ? 24  ALA B C   1 
ATOM 4685  O O   . ALA B 2 24  ? 14.920  -32.226 23.120  1.00 56.59  ? 24  ALA B O   1 
ATOM 4686  C CB  . ALA B 2 24  ? 14.912  -29.979 25.190  1.00 67.46  ? 24  ALA B CB  1 
ATOM 4687  N N   . SER B 2 25  ? 12.909  -31.231 22.774  1.00 63.90  ? 25  SER B N   1 
ATOM 4688  C CA  . SER B 2 25  ? 12.774  -31.702 21.377  1.00 60.75  ? 25  SER B CA  1 
ATOM 4689  C C   . SER B 2 25  ? 12.573  -30.498 20.459  1.00 60.61  ? 25  SER B C   1 
ATOM 4690  O O   . SER B 2 25  ? 11.979  -29.524 20.920  1.00 66.13  ? 25  SER B O   1 
ATOM 4691  C CB  . SER B 2 25  ? 11.649  -32.659 21.249  1.00 63.89  ? 25  SER B CB  1 
ATOM 4692  O OG  . SER B 2 25  ? 11.282  -33.188 22.515  1.00 82.14  ? 25  SER B OG  1 
ATOM 4693  N N   . GLY B 2 26  ? 13.093  -30.559 19.236  1.00 56.05  ? 26  GLY B N   1 
ATOM 4694  C CA  . GLY B 2 26  ? 13.000  -29.454 18.270  1.00 52.70  ? 26  GLY B CA  1 
ATOM 4695  C C   . GLY B 2 26  ? 14.352  -28.903 17.889  1.00 52.52  ? 26  GLY B C   1 
ATOM 4696  O O   . GLY B 2 26  ? 15.347  -29.331 18.493  1.00 48.64  ? 26  GLY B O   1 
ATOM 4697  N N   . TYR B 2 27  ? 14.391  -28.032 16.878  1.00 53.13  ? 27  TYR B N   1 
ATOM 4698  C CA  . TYR B 2 27  ? 15.678  -27.506 16.366  1.00 50.71  ? 27  TYR B CA  1 
ATOM 4699  C C   . TYR B 2 27  ? 16.385  -26.679 17.388  1.00 55.27  ? 27  TYR B C   1 
ATOM 4700  O O   . TYR B 2 27  ? 15.734  -25.829 18.013  1.00 51.48  ? 27  TYR B O   1 
ATOM 4701  C CB  . TYR B 2 27  ? 15.244  -26.646 15.184  1.00 50.25  ? 27  TYR B CB  1 
ATOM 4702  C CG  . TYR B 2 27  ? 16.290  -25.871 14.399  1.00 51.44  ? 27  TYR B CG  1 
ATOM 4703  C CD1 . TYR B 2 27  ? 17.251  -26.525 13.643  1.00 55.72  ? 27  TYR B CD1 1 
ATOM 4704  C CD2 . TYR B 2 27  ? 16.279  -24.484 14.375  1.00 50.29  ? 27  TYR B CD2 1 
ATOM 4705  C CE1 . TYR B 2 27  ? 18.191  -25.820 12.913  1.00 54.32  ? 27  TYR B CE1 1 
ATOM 4706  C CE2 . TYR B 2 27  ? 17.215  -23.768 13.652  1.00 49.44  ? 27  TYR B CE2 1 
ATOM 4707  C CZ  . TYR B 2 27  ? 18.173  -24.439 12.919  1.00 51.81  ? 27  TYR B CZ  1 
ATOM 4708  O OH  . TYR B 2 27  ? 19.100  -23.750 12.199  1.00 52.76  ? 27  TYR B OH  1 
ATOM 4709  N N   . MET B 2 28  ? 17.696  -26.867 17.502  1.00 56.09  ? 28  MET B N   1 
ATOM 4710  C CA  . MET B 2 28  ? 18.531  -26.018 18.372  1.00 50.91  ? 28  MET B CA  1 
ATOM 4711  C C   . MET B 2 28  ? 18.000  -26.062 19.807  1.00 52.72  ? 28  MET B C   1 
ATOM 4712  O O   . MET B 2 28  ? 18.055  -25.029 20.479  1.00 48.28  ? 28  MET B O   1 
ATOM 4713  C CB  . MET B 2 28  ? 18.581  -24.621 17.763  1.00 52.98  ? 28  MET B CB  1 
ATOM 4714  C CG  . MET B 2 28  ? 19.179  -24.568 16.374  1.00 54.04  ? 28  MET B CG  1 
ATOM 4715  S SD  . MET B 2 28  ? 20.732  -25.463 16.197  1.00 62.20  ? 28  MET B SD  1 
ATOM 4716  C CE  . MET B 2 28  ? 21.380  -24.717 14.697  1.00 61.58  ? 28  MET B CE  1 
ATOM 4717  N N   . SER B 2 29  ? 17.545  -27.222 20.259  1.00 57.93  ? 29  SER B N   1 
ATOM 4718  C CA  . SER B 2 29  ? 17.005  -27.414 21.631  1.00 58.61  ? 29  SER B CA  1 
ATOM 4719  C C   . SER B 2 29  ? 18.101  -27.157 22.669  1.00 58.91  ? 29  SER B C   1 
ATOM 4720  O O   . SER B 2 29  ? 17.801  -26.580 23.717  1.00 63.53  ? 29  SER B O   1 
ATOM 4721  C CB  . SER B 2 29  ? 16.406  -28.757 21.740  1.00 56.18  ? 29  SER B CB  1 
ATOM 4722  O OG  . SER B 2 29  ? 15.288  -28.851 20.875  1.00 58.73  ? 29  SER B OG  1 
ATOM 4723  N N   . SER B 2 30  ? 19.316  -27.588 22.385  1.00 58.77  ? 30  SER B N   1 
ATOM 4724  C CA  . SER B 2 30  ? 20.480  -27.446 23.290  1.00 63.84  ? 30  SER B CA  1 
ATOM 4725  C C   . SER B 2 30  ? 20.812  -25.972 23.557  1.00 58.24  ? 30  SER B C   1 
ATOM 4726  O O   . SER B 2 30  ? 21.274  -25.689 24.662  1.00 53.87  ? 30  SER B O   1 
ATOM 4727  C CB  . SER B 2 30  ? 21.644  -28.182 22.712  1.00 64.64  ? 30  SER B CB  1 
ATOM 4728  O OG  . SER B 2 30  ? 21.215  -29.384 22.090  1.00 67.03  ? 30  SER B OG  1 
ATOM 4729  N N   . THR B 2 31  ? 20.694  -25.091 22.577  1.00 49.43  ? 31  THR B N   1 
ATOM 4730  C CA  . THR B 2 31  ? 21.143  -23.689 22.644  1.00 46.84  ? 31  THR B CA  1 
ATOM 4731  C C   . THR B 2 31  ? 20.491  -22.812 23.680  1.00 47.06  ? 31  THR B C   1 
ATOM 4732  O O   . THR B 2 31  ? 21.175  -21.918 24.154  1.00 46.30  ? 31  THR B O   1 
ATOM 4733  C CB  . THR B 2 31  ? 20.835  -23.163 21.252  1.00 45.71  ? 31  THR B CB  1 
ATOM 4734  O OG1 . THR B 2 31  ? 19.419  -23.067 21.196  1.00 47.73  ? 31  THR B OG1 1 
ATOM 4735  C CG2 . THR B 2 31  ? 21.326  -24.106 20.171  1.00 45.77  ? 31  THR B CG2 1 
ATOM 4736  N N   . TYR B 2 32  ? 19.204  -22.920 23.923  1.00 54.30  ? 32  TYR B N   1 
ATOM 4737  C CA  . TYR B 2 32  ? 18.463  -21.961 24.782  1.00 56.62  ? 32  TYR B CA  1 
ATOM 4738  C C   . TYR B 2 32  ? 18.793  -21.809 26.257  1.00 57.35  ? 32  TYR B C   1 
ATOM 4739  O O   . TYR B 2 32  ? 19.203  -22.782 26.885  1.00 51.04  ? 32  TYR B O   1 
ATOM 4740  C CB  . TYR B 2 32  ? 17.047  -22.533 24.774  1.00 58.53  ? 32  TYR B CB  1 
ATOM 4741  C CG  . TYR B 2 32  ? 16.208  -22.404 23.511  1.00 66.95  ? 32  TYR B CG  1 
ATOM 4742  C CD1 . TYR B 2 32  ? 16.668  -22.852 22.283  1.00 67.12  ? 32  TYR B CD1 1 
ATOM 4743  C CD2 . TYR B 2 32  ? 14.928  -21.874 23.561  1.00 78.76  ? 32  TYR B CD2 1 
ATOM 4744  C CE1 . TYR B 2 32  ? 15.893  -22.751 21.142  1.00 72.67  ? 32  TYR B CE1 1 
ATOM 4745  C CE2 . TYR B 2 32  ? 14.141  -21.764 22.428  1.00 73.72  ? 32  TYR B CE2 1 
ATOM 4746  C CZ  . TYR B 2 32  ? 14.625  -22.207 21.214  1.00 70.68  ? 32  TYR B CZ  1 
ATOM 4747  O OH  . TYR B 2 32  ? 13.853  -22.099 20.097  1.00 67.14  ? 32  TYR B OH  1 
ATOM 4748  N N   . TYR B 2 33  ? 18.711  -20.575 26.784  1.00 65.44  ? 33  TYR B N   1 
ATOM 4749  C CA  . TYR B 2 33  ? 18.697  -20.345 28.214  1.00 72.48  ? 33  TYR B CA  1 
ATOM 4750  C C   . TYR B 2 33  ? 17.466  -21.090 28.732  1.00 80.27  ? 33  TYR B C   1 
ATOM 4751  O O   . TYR B 2 33  ? 16.391  -21.005 28.127  1.00 82.60  ? 33  TYR B O   1 
ATOM 4752  C CB  . TYR B 2 33  ? 18.730  -18.832 28.484  1.00 71.86  ? 33  TYR B CB  1 
ATOM 4753  C CG  . TYR B 2 33  ? 20.021  -18.093 28.131  1.00 66.92  ? 33  TYR B CG  1 
ATOM 4754  C CD1 . TYR B 2 33  ? 20.235  -17.556 26.864  1.00 68.29  ? 33  TYR B CD1 1 
ATOM 4755  C CD2 . TYR B 2 33  ? 21.019  -17.899 29.079  1.00 63.67  ? 33  TYR B CD2 1 
ATOM 4756  C CE1 . TYR B 2 33  ? 21.397  -16.861 26.551  1.00 66.52  ? 33  TYR B CE1 1 
ATOM 4757  C CE2 . TYR B 2 33  ? 22.191  -17.224 28.775  1.00 64.93  ? 33  TYR B CE2 1 
ATOM 4758  C CZ  . TYR B 2 33  ? 22.387  -16.701 27.508  1.00 66.15  ? 33  TYR B CZ  1 
ATOM 4759  O OH  . TYR B 2 33  ? 23.564  -16.045 27.248  1.00 64.09  ? 33  TYR B OH  1 
ATOM 4760  N N   . MET B 2 34  ? 17.645  -21.881 29.801  1.00 76.81  ? 34  MET B N   1 
ATOM 4761  C CA  . MET B 2 34  ? 16.578  -22.735 30.294  1.00 68.01  ? 34  MET B CA  1 
ATOM 4762  C C   . MET B 2 34  ? 16.402  -22.538 31.793  1.00 61.69  ? 34  MET B C   1 
ATOM 4763  O O   . MET B 2 34  ? 17.339  -22.169 32.499  1.00 59.00  ? 34  MET B O   1 
ATOM 4764  C CB  . MET B 2 34  ? 16.834  -24.202 29.930  1.00 70.53  ? 34  MET B CB  1 
ATOM 4765  C CG  . MET B 2 34  ? 16.089  -24.628 28.670  1.00 74.98  ? 34  MET B CG  1 
ATOM 4766  S SD  . MET B 2 34  ? 16.149  -26.393 28.303  1.00 79.52  ? 34  MET B SD  1 
ATOM 4767  C CE  . MET B 2 34  ? 17.918  -26.368 28.001  1.00 72.61  ? 34  MET B CE  1 
ATOM 4768  N N   . ALA B 2 35  ? 15.168  -22.768 32.251  1.00 57.64  ? 35  ALA B N   1 
ATOM 4769  C CA  . ALA B 2 35  ? 14.781  -22.419 33.605  1.00 61.85  ? 35  ALA B CA  1 
ATOM 4770  C C   . ALA B 2 35  ? 13.863  -23.484 34.203  1.00 62.83  ? 35  ALA B C   1 
ATOM 4771  O O   . ALA B 2 35  ? 13.168  -24.186 33.476  1.00 67.48  ? 35  ALA B O   1 
ATOM 4772  C CB  . ALA B 2 35  ? 14.097  -21.076 33.581  1.00 64.70  ? 35  ALA B CB  1 
ATOM 4773  N N   . TRP B 2 36  ? 13.875  -23.575 35.539  1.00 58.34  ? 36  TRP B N   1 
ATOM 4774  C CA  . TRP B 2 36  ? 12.816  -24.206 36.310  1.00 54.67  ? 36  TRP B CA  1 
ATOM 4775  C C   . TRP B 2 36  ? 11.950  -23.147 36.993  1.00 50.67  ? 36  TRP B C   1 
ATOM 4776  O O   . TRP B 2 36  ? 12.454  -22.194 37.591  1.00 40.36  ? 36  TRP B O   1 
ATOM 4777  C CB  . TRP B 2 36  ? 13.424  -25.149 37.347  1.00 57.08  ? 36  TRP B CB  1 
ATOM 4778  C CG  . TRP B 2 36  ? 13.972  -26.413 36.747  1.00 56.68  ? 36  TRP B CG  1 
ATOM 4779  C CD1 . TRP B 2 36  ? 15.270  -26.762 36.507  1.00 58.30  ? 36  TRP B CD1 1 
ATOM 4780  C CD2 . TRP B 2 36  ? 13.173  -27.524 36.317  1.00 54.69  ? 36  TRP B CD2 1 
ATOM 4781  N NE1 . TRP B 2 36  ? 15.335  -28.018 35.962  1.00 56.79  ? 36  TRP B NE1 1 
ATOM 4782  C CE2 . TRP B 2 36  ? 14.063  -28.510 35.834  1.00 54.11  ? 36  TRP B CE2 1 
ATOM 4783  C CE3 . TRP B 2 36  ? 11.799  -27.763 36.299  1.00 56.88  ? 36  TRP B CE3 1 
ATOM 4784  C CZ2 . TRP B 2 36  ? 13.615  -29.727 35.340  1.00 52.01  ? 36  TRP B CZ2 1 
ATOM 4785  C CZ3 . TRP B 2 36  ? 11.356  -28.961 35.791  1.00 60.00  ? 36  TRP B CZ3 1 
ATOM 4786  C CH2 . TRP B 2 36  ? 12.254  -29.927 35.328  1.00 58.45  ? 36  TRP B CH2 1 
ATOM 4787  N N   . PHE B 2 37  ? 10.633  -23.327 36.862  1.00 50.89  ? 37  PHE B N   1 
ATOM 4788  C CA  . PHE B 2 37  ? 9.651   -22.498 37.539  1.00 52.90  ? 37  PHE B CA  1 
ATOM 4789  C C   . PHE B 2 37  ? 8.725   -23.436 38.290  1.00 50.59  ? 37  PHE B C   1 
ATOM 4790  O O   . PHE B 2 37  ? 8.448   -24.524 37.811  1.00 54.19  ? 37  PHE B O   1 
ATOM 4791  C CB  . PHE B 2 37  ? 8.761   -21.650 36.628  1.00 58.47  ? 37  PHE B CB  1 
ATOM 4792  C CG  . PHE B 2 37  ? 9.435   -20.458 35.962  1.00 67.90  ? 37  PHE B CG  1 
ATOM 4793  C CD1 . PHE B 2 37  ? 10.208  -20.622 34.814  1.00 68.89  ? 37  PHE B CD1 1 
ATOM 4794  C CD2 . PHE B 2 37  ? 9.281   -19.175 36.482  1.00 69.92  ? 37  PHE B CD2 1 
ATOM 4795  C CE1 . PHE B 2 37  ? 10.814  -19.534 34.210  1.00 71.11  ? 37  PHE B CE1 1 
ATOM 4796  C CE2 . PHE B 2 37  ? 9.890   -18.087 35.874  1.00 71.30  ? 37  PHE B CE2 1 
ATOM 4797  C CZ  . PHE B 2 37  ? 10.659  -18.271 34.744  1.00 75.16  ? 37  PHE B CZ  1 
ATOM 4798  N N   . ARG B 2 38  ? 8.276   -23.016 39.469  1.00 51.63  ? 38  ARG B N   1 
ATOM 4799  C CA  . ARG B 2 38  ? 7.360   -23.812 40.259  1.00 53.65  ? 38  ARG B CA  1 
ATOM 4800  C C   . ARG B 2 38  ? 6.120   -22.974 40.531  1.00 57.30  ? 38  ARG B C   1 
ATOM 4801  O O   . ARG B 2 38  ? 6.197   -21.750 40.565  1.00 56.18  ? 38  ARG B O   1 
ATOM 4802  C CB  . ARG B 2 38  ? 8.002   -24.271 41.570  1.00 54.47  ? 38  ARG B CB  1 
ATOM 4803  C CG  . ARG B 2 38  ? 8.265   -23.179 42.597  1.00 54.17  ? 38  ARG B CG  1 
ATOM 4804  C CD  . ARG B 2 38  ? 8.909   -23.812 43.821  1.00 55.93  ? 38  ARG B CD  1 
ATOM 4805  N NE  . ARG B 2 38  ? 9.294   -22.865 44.868  1.00 54.48  ? 38  ARG B NE  1 
ATOM 4806  C CZ  . ARG B 2 38  ? 10.061  -23.180 45.908  1.00 59.95  ? 38  ARG B CZ  1 
ATOM 4807  N NH1 . ARG B 2 38  ? 10.420  -24.437 46.129  1.00 55.46  ? 38  ARG B NH1 1 
ATOM 4808  N NH2 . ARG B 2 38  ? 10.470  -22.226 46.736  1.00 69.58  ? 38  ARG B NH2 1 
ATOM 4809  N N   . GLN B 2 39  ? 4.983   -23.651 40.707  1.00 61.43  ? 39  GLN B N   1 
ATOM 4810  C CA  . GLN B 2 39  ? 3.736   -22.973 41.001  1.00 61.33  ? 39  GLN B CA  1 
ATOM 4811  C C   . GLN B 2 39  ? 3.166   -23.575 42.279  1.00 67.42  ? 39  GLN B C   1 
ATOM 4812  O O   . GLN B 2 39  ? 2.448   -24.577 42.216  1.00 76.83  ? 39  GLN B O   1 
ATOM 4813  C CB  . GLN B 2 39  ? 2.746   -23.084 39.845  1.00 58.90  ? 39  GLN B CB  1 
ATOM 4814  C CG  . GLN B 2 39  ? 1.654   -22.025 39.895  1.00 60.28  ? 39  GLN B CG  1 
ATOM 4815  C CD  . GLN B 2 39  ? 0.351   -22.542 39.344  1.00 67.40  ? 39  GLN B CD  1 
ATOM 4816  O OE1 . GLN B 2 39  ? 0.271   -22.966 38.185  1.00 79.40  ? 39  GLN B OE1 1 
ATOM 4817  N NE2 . GLN B 2 39  ? -0.668  -22.551 40.191  1.00 71.50  ? 39  GLN B NE2 1 
ATOM 4818  N N   . PRO B 2 40  ? 3.479   -22.991 43.465  1.00 64.90  ? 40  PRO B N   1 
ATOM 4819  C CA  . PRO B 2 40  ? 2.891   -23.450 44.730  1.00 62.01  ? 40  PRO B CA  1 
ATOM 4820  C C   . PRO B 2 40  ? 1.362   -23.357 44.719  1.00 61.63  ? 40  PRO B C   1 
ATOM 4821  O O   . PRO B 2 40  ? 0.780   -22.504 44.052  1.00 54.61  ? 40  PRO B O   1 
ATOM 4822  C CB  . PRO B 2 40  ? 3.545   -22.562 45.808  1.00 61.01  ? 40  PRO B CB  1 
ATOM 4823  C CG  . PRO B 2 40  ? 4.791   -22.023 45.130  1.00 62.56  ? 40  PRO B CG  1 
ATOM 4824  C CD  . PRO B 2 40  ? 4.430   -21.881 43.654  1.00 59.29  ? 40  PRO B CD  1 
ATOM 4825  N N   . PRO B 2 41  ? 0.646   -24.262 45.419  1.00 69.92  ? 41  PRO B N   1 
ATOM 4826  C CA  . PRO B 2 41  ? -0.812  -24.308 45.321  1.00 74.57  ? 41  PRO B CA  1 
ATOM 4827  C C   . PRO B 2 41  ? -1.438  -22.932 45.530  1.00 70.06  ? 41  PRO B C   1 
ATOM 4828  O O   . PRO B 2 41  ? -1.025  -22.213 46.443  1.00 55.10  ? 41  PRO B O   1 
ATOM 4829  C CB  . PRO B 2 41  ? -1.192  -25.322 46.419  1.00 73.96  ? 41  PRO B CB  1 
ATOM 4830  C CG  . PRO B 2 41  ? 0.011   -26.236 46.496  1.00 74.30  ? 41  PRO B CG  1 
ATOM 4831  C CD  . PRO B 2 41  ? 1.187   -25.291 46.320  1.00 74.52  ? 41  PRO B CD  1 
ATOM 4832  N N   . GLY B 2 42  ? -2.388  -22.588 44.638  1.00 73.41  ? 42  GLY B N   1 
ATOM 4833  C CA  . GLY B 2 42  ? -3.178  -21.364 44.706  1.00 76.45  ? 42  GLY B CA  1 
ATOM 4834  C C   . GLY B 2 42  ? -2.342  -20.086 44.586  1.00 74.98  ? 42  GLY B C   1 
ATOM 4835  O O   . GLY B 2 42  ? -2.718  -19.053 45.124  1.00 67.14  ? 42  GLY B O   1 
ATOM 4836  N N   . LYS B 2 43  ? -1.208  -20.157 43.881  1.00 80.71  ? 43  LYS B N   1 
ATOM 4837  C CA  . LYS B 2 43  ? -0.361  -18.997 43.652  1.00 78.25  ? 43  LYS B CA  1 
ATOM 4838  C C   . LYS B 2 43  ? -0.006  -18.937 42.166  1.00 83.50  ? 43  LYS B C   1 
ATOM 4839  O O   . LYS B 2 43  ? -0.553  -19.677 41.345  1.00 79.40  ? 43  LYS B O   1 
ATOM 4840  C CB  . LYS B 2 43  ? 0.858   -19.065 44.580  1.00 73.85  ? 43  LYS B CB  1 
ATOM 4841  C CG  . LYS B 2 43  ? 0.525   -18.924 46.058  1.00 73.76  ? 43  LYS B CG  1 
ATOM 4842  C CD  . LYS B 2 43  ? 1.683   -19.243 46.998  1.00 79.32  ? 43  LYS B CD  1 
ATOM 4843  C CE  . LYS B 2 43  ? 2.948   -18.459 46.768  1.00 78.65  ? 43  LYS B CE  1 
ATOM 4844  N NZ  . LYS B 2 43  ? 4.000   -18.895 47.694  1.00 74.71  ? 43  LYS B NZ  1 
ATOM 4845  N N   . GLY B 2 44  ? 0.889   -18.011 41.817  1.00 84.52  ? 44  GLY B N   1 
ATOM 4846  C CA  . GLY B 2 44  ? 1.391   -17.923 40.457  1.00 77.51  ? 44  GLY B CA  1 
ATOM 4847  C C   . GLY B 2 44  ? 2.744   -18.613 40.325  1.00 68.09  ? 44  GLY B C   1 
ATOM 4848  O O   . GLY B 2 44  ? 3.323   -19.057 41.326  1.00 61.73  ? 44  GLY B O   1 
ATOM 4849  N N   . LEU B 2 45  ? 3.218   -18.667 39.070  1.00 58.74  ? 45  LEU B N   1 
ATOM 4850  C CA  . LEU B 2 45  ? 4.555   -19.134 38.723  1.00 56.13  ? 45  LEU B CA  1 
ATOM 4851  C C   . LEU B 2 45  ? 5.617   -18.324 39.468  1.00 50.82  ? 45  LEU B C   1 
ATOM 4852  O O   . LEU B 2 45  ? 5.393   -17.172 39.804  1.00 50.89  ? 45  LEU B O   1 
ATOM 4853  C CB  . LEU B 2 45  ? 4.775   -19.036 37.210  1.00 61.34  ? 45  LEU B CB  1 
ATOM 4854  C CG  . LEU B 2 45  ? 4.526   -20.292 36.359  1.00 70.82  ? 45  LEU B CG  1 
ATOM 4855  C CD1 . LEU B 2 45  ? 5.255   -21.508 36.942  1.00 69.02  ? 45  LEU B CD1 1 
ATOM 4856  C CD2 . LEU B 2 45  ? 3.033   -20.584 36.142  1.00 77.64  ? 45  LEU B CD2 1 
ATOM 4857  N N   . GLU B 2 46  ? 6.782   -18.938 39.714  1.00 52.48  ? 46  GLU B N   1 
ATOM 4858  C CA  . GLU B 2 46  ? 7.897   -18.276 40.385  1.00 53.43  ? 46  GLU B CA  1 
ATOM 4859  C C   . GLU B 2 46  ? 9.196   -19.017 40.095  1.00 45.60  ? 46  GLU B C   1 
ATOM 4860  O O   . GLU B 2 46  ? 9.246   -20.234 40.062  1.00 53.50  ? 46  GLU B O   1 
ATOM 4861  C CB  . GLU B 2 46  ? 7.731   -18.088 41.898  1.00 60.27  ? 46  GLU B CB  1 
ATOM 4862  C CG  . GLU B 2 46  ? 6.901   -19.152 42.614  1.00 67.86  ? 46  GLU B CG  1 
ATOM 4863  C CD  . GLU B 2 46  ? 6.425   -18.708 43.990  1.00 72.49  ? 46  GLU B CD  1 
ATOM 4864  O OE1 . GLU B 2 46  ? 7.306   -18.464 44.857  1.00 59.78  ? 46  GLU B OE1 1 
ATOM 4865  O OE2 . GLU B 2 46  ? 5.179   -18.585 44.176  1.00 75.44  ? 46  GLU B OE2 1 
ATOM 4866  N N   . GLY B 2 47  ? 10.266  -18.274 39.884  1.00 41.83  ? 47  GLY B N   1 
ATOM 4867  C CA  . GLY B 2 47  ? 11.458  -18.889 39.343  1.00 42.99  ? 47  GLY B CA  1 
ATOM 4868  C C   . GLY B 2 47  ? 12.231  -19.633 40.423  1.00 41.48  ? 47  GLY B C   1 
ATOM 4869  O O   . GLY B 2 47  ? 12.603  -19.062 41.433  1.00 45.03  ? 47  GLY B O   1 
ATOM 4870  N N   . VAL B 2 48  ? 12.500  -20.906 40.189  1.00 40.42  ? 48  VAL B N   1 
ATOM 4871  C CA  . VAL B 2 48  ? 13.318  -21.663 41.113  1.00 47.48  ? 48  VAL B CA  1 
ATOM 4872  C C   . VAL B 2 48  ? 14.802  -21.544 40.740  1.00 51.26  ? 48  VAL B C   1 
ATOM 4873  O O   . VAL B 2 48  ? 15.623  -21.147 41.569  1.00 49.22  ? 48  VAL B O   1 
ATOM 4874  C CB  . VAL B 2 48  ? 12.799  -23.113 41.094  1.00 50.02  ? 48  VAL B CB  1 
ATOM 4875  C CG1 . VAL B 2 48  ? 13.545  -24.001 42.092  1.00 51.33  ? 48  VAL B CG1 1 
ATOM 4876  C CG2 . VAL B 2 48  ? 11.294  -23.150 41.343  1.00 47.15  ? 48  VAL B CG2 1 
ATOM 4877  N N   . ALA B 2 49  ? 15.143  -21.894 39.487  1.00 51.21  ? 49  ALA B N   1 
ATOM 4878  C CA  . ALA B 2 49  ? 16.533  -21.980 39.059  1.00 46.85  ? 49  ALA B CA  1 
ATOM 4879  C C   . ALA B 2 49  ? 16.677  -21.707 37.555  1.00 44.94  ? 49  ALA B C   1 
ATOM 4880  O O   . ALA B 2 49  ? 15.780  -22.038 36.785  1.00 44.80  ? 49  ALA B O   1 
ATOM 4881  C CB  . ALA B 2 49  ? 17.070  -23.333 39.453  1.00 45.06  ? 49  ALA B CB  1 
ATOM 4882  N N   . LEU B 2 50  ? 17.809  -21.091 37.157  1.00 43.61  ? 50  LEU B N   1 
ATOM 4883  C CA  . LEU B 2 50  ? 18.091  -20.733 35.771  1.00 46.04  ? 50  LEU B CA  1 
ATOM 4884  C C   . LEU B 2 50  ? 19.507  -21.164 35.394  1.00 51.95  ? 50  LEU B C   1 
ATOM 4885  O O   . LEU B 2 50  ? 20.401  -21.151 36.256  1.00 51.67  ? 50  LEU B O   1 
ATOM 4886  C CB  . LEU B 2 50  ? 17.999  -19.229 35.575  1.00 46.96  ? 50  LEU B CB  1 
ATOM 4887  C CG  . LEU B 2 50  ? 16.785  -18.515 36.165  1.00 53.55  ? 50  LEU B CG  1 
ATOM 4888  C CD1 . LEU B 2 50  ? 17.111  -17.045 35.961  1.00 61.89  ? 50  LEU B CD1 1 
ATOM 4889  C CD2 . LEU B 2 50  ? 15.429  -18.859 35.550  1.00 50.83  ? 50  LEU B CD2 1 
ATOM 4890  N N   . ILE B 2 51  ? 19.700  -21.454 34.087  1.00 49.37  ? 51  ILE B N   1 
ATOM 4891  C CA  . ILE B 2 51  ? 20.928  -22.063 33.588  1.00 48.14  ? 51  ILE B CA  1 
ATOM 4892  C C   . ILE B 2 51  ? 21.195  -21.639 32.141  1.00 48.03  ? 51  ILE B C   1 
ATOM 4893  O O   . ILE B 2 51  ? 20.323  -21.752 31.274  1.00 45.59  ? 51  ILE B O   1 
ATOM 4894  C CB  . ILE B 2 51  ? 20.863  -23.597 33.740  1.00 50.20  ? 51  ILE B CB  1 
ATOM 4895  C CG1 . ILE B 2 51  ? 22.179  -24.256 33.327  1.00 53.02  ? 51  ILE B CG1 1 
ATOM 4896  C CG2 . ILE B 2 51  ? 19.663  -24.202 32.997  1.00 50.72  ? 51  ILE B CG2 1 
ATOM 4897  C CD1 . ILE B 2 51  ? 23.259  -24.227 34.386  1.00 55.77  ? 51  ILE B CD1 1 
ATOM 4898  N N   . SER B 2 52  ? 22.437  -21.191 31.890  1.00 46.59  ? 52  SER B N   1 
ATOM 4899  C CA  . SER B 2 52  ? 22.875  -20.741 30.575  1.00 47.80  ? 52  SER B CA  1 
ATOM 4900  C C   . SER B 2 52  ? 23.056  -21.927 29.623  1.00 58.12  ? 52  SER B C   1 
ATOM 4901  O O   . SER B 2 52  ? 23.092  -23.086 30.050  1.00 57.17  ? 52  SER B O   1 
ATOM 4902  C CB  . SER B 2 52  ? 24.155  -19.950 30.678  1.00 47.07  ? 52  SER B CB  1 
ATOM 4903  O OG  . SER B 2 52  ? 25.232  -20.768 31.120  1.00 49.74  ? 52  SER B OG  1 
ATOM 4904  N N   . PRO B 2 53  ? 23.178  -21.684 28.294  1.00 61.55  ? 53  PRO B N   1 
ATOM 4905  C CA  . PRO B 2 53  ? 23.247  -22.771 27.315  1.00 60.25  ? 53  PRO B CA  1 
ATOM 4906  C C   . PRO B 2 53  ? 24.294  -23.851 27.570  1.00 58.55  ? 53  PRO B C   1 
ATOM 4907  O O   . PRO B 2 53  ? 24.085  -25.002 27.195  1.00 61.22  ? 53  PRO B O   1 
ATOM 4908  C CB  . PRO B 2 53  ? 23.508  -22.023 25.992  1.00 64.19  ? 53  PRO B CB  1 
ATOM 4909  C CG  . PRO B 2 53  ? 22.832  -20.680 26.202  1.00 63.85  ? 53  PRO B CG  1 
ATOM 4910  C CD  . PRO B 2 53  ? 23.137  -20.359 27.652  1.00 63.18  ? 53  PRO B CD  1 
ATOM 4911  N N   . TYR B 2 54  ? 25.422  -23.475 28.184  1.00 60.94  ? 54  TYR B N   1 
ATOM 4912  C CA  . TYR B 2 54  ? 26.504  -24.424 28.431  1.00 60.32  ? 54  TYR B CA  1 
ATOM 4913  C C   . TYR B 2 54  ? 26.732  -24.628 29.934  1.00 55.85  ? 54  TYR B C   1 
ATOM 4914  O O   . TYR B 2 54  ? 27.744  -25.203 30.337  1.00 47.20  ? 54  TYR B O   1 
ATOM 4915  C CB  . TYR B 2 54  ? 27.725  -23.917 27.653  1.00 62.75  ? 54  TYR B CB  1 
ATOM 4916  C CG  . TYR B 2 54  ? 27.557  -23.997 26.136  1.00 68.13  ? 54  TYR B CG  1 
ATOM 4917  C CD1 . TYR B 2 54  ? 27.602  -25.224 25.481  1.00 62.96  ? 54  TYR B CD1 1 
ATOM 4918  C CD2 . TYR B 2 54  ? 27.360  -22.857 25.353  1.00 66.32  ? 54  TYR B CD2 1 
ATOM 4919  C CE1 . TYR B 2 54  ? 27.450  -25.316 24.108  1.00 56.81  ? 54  TYR B CE1 1 
ATOM 4920  C CE2 . TYR B 2 54  ? 27.208  -22.941 23.978  1.00 58.95  ? 54  TYR B CE2 1 
ATOM 4921  C CZ  . TYR B 2 54  ? 27.254  -24.174 23.364  1.00 52.34  ? 54  TYR B CZ  1 
ATOM 4922  O OH  . TYR B 2 54  ? 27.127  -24.287 22.030  1.00 53.52  ? 54  TYR B OH  1 
ATOM 4923  N N   . GLY B 2 55  ? 25.781  -24.152 30.751  1.00 54.56  ? 55  GLY B N   1 
ATOM 4924  C CA  . GLY B 2 55  ? 25.781  -24.366 32.189  1.00 56.09  ? 55  GLY B CA  1 
ATOM 4925  C C   . GLY B 2 55  ? 26.864  -23.584 32.938  1.00 60.36  ? 55  GLY B C   1 
ATOM 4926  O O   . GLY B 2 55  ? 27.132  -23.881 34.104  1.00 56.99  ? 55  GLY B O   1 
ATOM 4927  N N   . GLY B 2 56  ? 27.451  -22.565 32.290  1.00 62.00  ? 56  GLY B N   1 
ATOM 4928  C CA  . GLY B 2 56  ? 28.502  -21.759 32.897  1.00 58.33  ? 56  GLY B CA  1 
ATOM 4929  C C   . GLY B 2 56  ? 27.939  -20.664 33.806  1.00 53.27  ? 56  GLY B C   1 
ATOM 4930  O O   . GLY B 2 56  ? 28.698  -19.990 34.496  1.00 50.06  ? 56  GLY B O   1 
ATOM 4931  N N   . ALA B 2 57  ? 26.610  -20.479 33.781  1.00 47.22  ? 57  ALA B N   1 
ATOM 4932  C CA  . ALA B 2 57  ? 25.953  -19.487 34.615  1.00 46.28  ? 57  ALA B CA  1 
ATOM 4933  C C   . ALA B 2 57  ? 24.584  -19.986 35.079  1.00 46.95  ? 57  ALA B C   1 
ATOM 4934  O O   . ALA B 2 57  ? 23.781  -20.475 34.279  1.00 40.47  ? 57  ALA B O   1 
ATOM 4935  C CB  . ALA B 2 57  ? 25.829  -18.183 33.866  1.00 49.33  ? 57  ALA B CB  1 
ATOM 4936  N N   . THR B 2 58  ? 24.348  -19.805 36.389  1.00 51.89  ? 58  THR B N   1 
ATOM 4937  C CA  . THR B 2 58  ? 23.213  -20.345 37.121  1.00 53.93  ? 58  THR B CA  1 
ATOM 4938  C C   . THR B 2 58  ? 22.711  -19.289 38.092  1.00 54.35  ? 58  THR B C   1 
ATOM 4939  O O   . THR B 2 58  ? 23.477  -18.814 38.930  1.00 54.06  ? 58  THR B O   1 
ATOM 4940  C CB  . THR B 2 58  ? 23.616  -21.555 37.966  1.00 55.96  ? 58  THR B CB  1 
ATOM 4941  O OG1 . THR B 2 58  ? 24.676  -21.070 38.795  1.00 60.10  ? 58  THR B OG1 1 
ATOM 4942  C CG2 . THR B 2 58  ? 24.002  -22.776 37.154  1.00 52.57  ? 58  THR B CG2 1 
ATOM 4943  N N   . ASN B 2 59  ? 21.413  -19.006 38.044  1.00 54.70  ? 59  ASN B N   1 
ATOM 4944  C CA  . ASN B 2 59  ? 20.793  -18.257 39.121  1.00 59.93  ? 59  ASN B CA  1 
ATOM 4945  C C   . ASN B 2 59  ? 19.882  -19.212 39.884  1.00 61.64  ? 59  ASN B C   1 
ATOM 4946  O O   . ASN B 2 59  ? 19.510  -20.246 39.327  1.00 65.91  ? 59  ASN B O   1 
ATOM 4947  C CB  . ASN B 2 59  ? 20.079  -17.014 38.603  1.00 60.79  ? 59  ASN B CB  1 
ATOM 4948  C CG  . ASN B 2 59  ? 19.669  -16.100 39.732  1.00 61.68  ? 59  ASN B CG  1 
ATOM 4949  O OD1 . ASN B 2 59  ? 20.514  -15.678 40.529  1.00 78.29  ? 59  ASN B OD1 1 
ATOM 4950  N ND2 . ASN B 2 59  ? 18.383  -15.816 39.851  1.00 60.06  ? 59  ASN B ND2 1 
ATOM 4951  N N   . TYR B 2 60  ? 19.588  -18.870 41.153  1.00 56.89  ? 60  TYR B N   1 
ATOM 4952  C CA  . TYR B 2 60  ? 18.637  -19.584 41.994  1.00 52.94  ? 60  TYR B CA  1 
ATOM 4953  C C   . TYR B 2 60  ? 17.737  -18.598 42.749  1.00 51.19  ? 60  TYR B C   1 
ATOM 4954  O O   . TYR B 2 60  ? 18.179  -17.526 43.143  1.00 57.44  ? 60  TYR B O   1 
ATOM 4955  C CB  . TYR B 2 60  ? 19.433  -20.431 42.991  1.00 50.21  ? 60  TYR B CB  1 
ATOM 4956  C CG  . TYR B 2 60  ? 20.264  -21.554 42.395  1.00 45.79  ? 60  TYR B CG  1 
ATOM 4957  C CD1 . TYR B 2 60  ? 19.672  -22.751 41.998  1.00 48.32  ? 60  TYR B CD1 1 
ATOM 4958  C CD2 . TYR B 2 60  ? 21.640  -21.434 42.266  1.00 44.32  ? 60  TYR B CD2 1 
ATOM 4959  C CE1 . TYR B 2 60  ? 20.421  -23.795 41.472  1.00 48.17  ? 60  TYR B CE1 1 
ATOM 4960  C CE2 . TYR B 2 60  ? 22.402  -22.468 41.738  1.00 48.16  ? 60  TYR B CE2 1 
ATOM 4961  C CZ  . TYR B 2 60  ? 21.792  -23.650 41.339  1.00 49.24  ? 60  TYR B CZ  1 
ATOM 4962  O OH  . TYR B 2 60  ? 22.525  -24.666 40.799  1.00 49.35  ? 60  TYR B OH  1 
ATOM 4963  N N   . ALA B 2 61  ? 16.474  -18.961 42.987  1.00 47.72  ? 61  ALA B N   1 
ATOM 4964  C CA  . ALA B 2 61  ? 15.680  -18.274 43.995  1.00 50.53  ? 61  ALA B CA  1 
ATOM 4965  C C   . ALA B 2 61  ? 16.294  -18.514 45.378  1.00 55.18  ? 61  ALA B C   1 
ATOM 4966  O O   . ALA B 2 61  ? 16.902  -19.556 45.593  1.00 59.17  ? 61  ALA B O   1 
ATOM 4967  C CB  . ALA B 2 61  ? 14.247  -18.759 43.928  1.00 48.10  ? 61  ALA B CB  1 
ATOM 4968  N N   . ASP B 2 62  ? 16.146  -17.562 46.317  1.00 59.88  ? 62  ASP B N   1 
ATOM 4969  C CA  . ASP B 2 62  ? 16.726  -17.687 47.656  1.00 63.93  ? 62  ASP B CA  1 
ATOM 4970  C C   . ASP B 2 62  ? 16.091  -18.845 48.426  1.00 60.73  ? 62  ASP B C   1 
ATOM 4971  O O   . ASP B 2 62  ? 16.790  -19.534 49.179  1.00 49.34  ? 62  ASP B O   1 
ATOM 4972  C CB  . ASP B 2 62  ? 16.582  -16.416 48.481  1.00 68.10  ? 62  ASP B CB  1 
ATOM 4973  C CG  . ASP B 2 62  ? 17.452  -15.251 48.036  1.00 76.21  ? 62  ASP B CG  1 
ATOM 4974  O OD1 . ASP B 2 62  ? 18.691  -15.348 48.231  1.00 80.22  ? 62  ASP B OD1 1 
ATOM 4975  O OD2 . ASP B 2 62  ? 16.880  -14.270 47.484  1.00 70.92  ? 62  ASP B OD2 1 
ATOM 4976  N N   . SER B 2 63  ? 14.770  -19.023 48.209  1.00 57.60  ? 63  SER B N   1 
ATOM 4977  C CA  . SER B 2 63  ? 13.951  -20.073 48.802  1.00 52.15  ? 63  SER B CA  1 
ATOM 4978  C C   . SER B 2 63  ? 14.695  -21.404 48.831  1.00 51.65  ? 63  SER B C   1 
ATOM 4979  O O   . SER B 2 63  ? 14.586  -22.166 49.794  1.00 44.66  ? 63  SER B O   1 
ATOM 4980  C CB  . SER B 2 63  ? 12.657  -20.239 48.038  1.00 53.38  ? 63  SER B CB  1 
ATOM 4981  O OG  . SER B 2 63  ? 12.118  -18.989 47.625  1.00 58.75  ? 63  SER B OG  1 
ATOM 4982  N N   . VAL B 2 64  ? 15.440  -21.669 47.745  1.00 52.89  ? 64  VAL B N   1 
ATOM 4983  C CA  . VAL B 2 64  ? 16.015  -22.980 47.501  1.00 47.05  ? 64  VAL B CA  1 
ATOM 4984  C C   . VAL B 2 64  ? 17.540  -22.947 47.442  1.00 42.40  ? 64  VAL B C   1 
ATOM 4985  O O   . VAL B 2 64  ? 18.125  -24.003 47.270  1.00 43.30  ? 64  VAL B O   1 
ATOM 4986  C CB  . VAL B 2 64  ? 15.441  -23.607 46.214  1.00 44.47  ? 64  VAL B CB  1 
ATOM 4987  C CG1 . VAL B 2 64  ? 13.937  -23.381 46.097  1.00 46.85  ? 64  VAL B CG1 1 
ATOM 4988  C CG2 . VAL B 2 64  ? 16.135  -23.125 44.954  1.00 42.64  ? 64  VAL B CG2 1 
ATOM 4989  N N   . LYS B 2 65  ? 18.194  -21.789 47.565  1.00 41.36  ? 65  LYS B N   1 
ATOM 4990  C CA  . LYS B 2 65  ? 19.648  -21.774 47.475  1.00 49.01  ? 65  LYS B CA  1 
ATOM 4991  C C   . LYS B 2 65  ? 20.222  -22.712 48.535  1.00 47.60  ? 65  LYS B C   1 
ATOM 4992  O O   . LYS B 2 65  ? 19.631  -22.882 49.600  1.00 52.77  ? 65  LYS B O   1 
ATOM 4993  C CB  . LYS B 2 65  ? 20.240  -20.377 47.689  1.00 61.37  ? 65  LYS B CB  1 
ATOM 4994  C CG  . LYS B 2 65  ? 19.986  -19.350 46.593  1.00 70.47  ? 65  LYS B CG  1 
ATOM 4995  C CD  . LYS B 2 65  ? 20.526  -17.961 46.923  1.00 77.96  ? 65  LYS B CD  1 
ATOM 4996  C CE  . LYS B 2 65  ? 20.248  -16.949 45.855  1.00 83.64  ? 65  LYS B CE  1 
ATOM 4997  N NZ  . LYS B 2 65  ? 20.789  -15.625 46.176  1.00 88.55  ? 65  LYS B NZ  1 
ATOM 4998  N N   . GLY B 2 66  ? 21.358  -23.346 48.239  1.00 43.46  ? 66  GLY B N   1 
ATOM 4999  C CA  . GLY B 2 66  ? 21.947  -24.303 49.164  1.00 47.59  ? 66  GLY B CA  1 
ATOM 5000  C C   . GLY B 2 66  ? 21.288  -25.695 49.168  1.00 50.26  ? 66  GLY B C   1 
ATOM 5001  O O   . GLY B 2 66  ? 21.840  -26.647 49.724  1.00 50.51  ? 66  GLY B O   1 
ATOM 5002  N N   . ARG B 2 67  ? 20.103  -25.850 48.573  1.00 52.08  ? 67  ARG B N   1 
ATOM 5003  C CA  . ARG B 2 67  ? 19.397  -27.123 48.636  1.00 51.91  ? 67  ARG B CA  1 
ATOM 5004  C C   . ARG B 2 67  ? 19.282  -27.716 47.235  1.00 51.24  ? 67  ARG B C   1 
ATOM 5005  O O   . ARG B 2 67  ? 19.486  -28.916 47.055  1.00 58.23  ? 67  ARG B O   1 
ATOM 5006  C CB  . ARG B 2 67  ? 18.024  -26.959 49.302  1.00 52.81  ? 67  ARG B CB  1 
ATOM 5007  C CG  . ARG B 2 67  ? 18.107  -26.387 50.712  1.00 53.76  ? 67  ARG B CG  1 
ATOM 5008  C CD  . ARG B 2 67  ? 16.777  -26.252 51.441  1.00 49.75  ? 67  ARG B CD  1 
ATOM 5009  N NE  . ARG B 2 67  ? 15.764  -25.549 50.646  1.00 46.80  ? 67  ARG B NE  1 
ATOM 5010  C CZ  . ARG B 2 67  ? 14.650  -26.118 50.209  1.00 48.31  ? 67  ARG B CZ  1 
ATOM 5011  N NH1 . ARG B 2 67  ? 14.439  -27.405 50.407  1.00 50.90  ? 67  ARG B NH1 1 
ATOM 5012  N NH2 . ARG B 2 67  ? 13.745  -25.409 49.566  1.00 48.20  ? 67  ARG B NH2 1 
ATOM 5013  N N   . PHE B 2 68  ? 18.950  -26.869 46.254  1.00 46.12  ? 68  PHE B N   1 
ATOM 5014  C CA  . PHE B 2 68  ? 18.728  -27.318 44.892  1.00 46.59  ? 68  PHE B CA  1 
ATOM 5015  C C   . PHE B 2 68  ? 19.992  -27.039 44.087  1.00 45.07  ? 68  PHE B C   1 
ATOM 5016  O O   . PHE B 2 68  ? 20.741  -26.120 44.409  1.00 44.79  ? 68  PHE B O   1 
ATOM 5017  C CB  . PHE B 2 68  ? 17.512  -26.651 44.228  1.00 46.57  ? 68  PHE B CB  1 
ATOM 5018  C CG  . PHE B 2 68  ? 16.106  -26.912 44.780  1.00 42.68  ? 68  PHE B CG  1 
ATOM 5019  C CD1 . PHE B 2 68  ? 15.898  -27.549 46.007  1.00 41.99  ? 68  PHE B CD1 1 
ATOM 5020  C CD2 . PHE B 2 68  ? 14.983  -26.457 44.078  1.00 39.10  ? 68  PHE B CD2 1 
ATOM 5021  C CE1 . PHE B 2 68  ? 14.610  -27.726 46.501  1.00 43.34  ? 68  PHE B CE1 1 
ATOM 5022  C CE2 . PHE B 2 68  ? 13.696  -26.638 44.570  1.00 39.25  ? 68  PHE B CE2 1 
ATOM 5023  C CZ  . PHE B 2 68  ? 13.511  -27.261 45.788  1.00 42.89  ? 68  PHE B CZ  1 
ATOM 5024  N N   . THR B 2 69  ? 20.227  -27.871 43.064  1.00 47.18  ? 69  THR B N   1 
ATOM 5025  C CA  . THR B 2 69  ? 21.185  -27.564 42.007  1.00 54.42  ? 69  THR B CA  1 
ATOM 5026  C C   . THR B 2 69  ? 20.490  -27.723 40.649  1.00 59.19  ? 69  THR B C   1 
ATOM 5027  O O   . THR B 2 69  ? 19.662  -28.627 40.461  1.00 51.69  ? 69  THR B O   1 
ATOM 5028  C CB  . THR B 2 69  ? 22.446  -28.435 42.111  1.00 50.36  ? 69  THR B CB  1 
ATOM 5029  O OG1 . THR B 2 69  ? 23.181  -28.000 43.251  1.00 50.55  ? 69  THR B OG1 1 
ATOM 5030  C CG2 . THR B 2 69  ? 23.375  -28.288 40.919  1.00 46.72  ? 69  THR B CG2 1 
ATOM 5031  N N   . ILE B 2 70  ? 20.913  -26.922 39.644  1.00 56.95  ? 70  ILE B N   1 
ATOM 5032  C CA  . ILE B 2 70  ? 20.380  -26.995 38.241  1.00 59.94  ? 70  ILE B CA  1 
ATOM 5033  C C   . ILE B 2 70  ? 21.500  -27.419 37.278  1.00 65.72  ? 70  ILE B C   1 
ATOM 5034  O O   . ILE B 2 70  ? 22.586  -26.829 37.368  1.00 66.28  ? 70  ILE B O   1 
ATOM 5035  C CB  . ILE B 2 70  ? 19.791  -25.653 37.772  1.00 58.31  ? 70  ILE B CB  1 
ATOM 5036  C CG1 . ILE B 2 70  ? 19.174  -25.771 36.384  1.00 58.38  ? 70  ILE B CG1 1 
ATOM 5037  C CG2 . ILE B 2 70  ? 20.820  -24.526 37.833  1.00 55.18  ? 70  ILE B CG2 1 
ATOM 5038  C CD1 . ILE B 2 70  ? 18.009  -24.833 36.144  1.00 55.57  ? 70  ILE B CD1 1 
ATOM 5039  N N   . SER B 2 71  ? 21.281  -28.461 36.462  1.00 68.16  ? 71  SER B N   1 
ATOM 5040  C CA  . SER B 2 71  ? 22.309  -28.952 35.505  1.00 63.08  ? 71  SER B CA  1 
ATOM 5041  C C   . SER B 2 71  ? 21.729  -29.298 34.127  1.00 59.39  ? 71  SER B C   1 
ATOM 5042  O O   . SER B 2 71  ? 20.547  -29.631 34.080  1.00 68.00  ? 71  SER B O   1 
ATOM 5043  C CB  . SER B 2 71  ? 23.002  -30.128 36.099  1.00 61.73  ? 71  SER B CB  1 
ATOM 5044  O OG  . SER B 2 71  ? 23.977  -29.712 37.043  1.00 65.60  ? 71  SER B OG  1 
ATOM 5045  N N   . ARG B 2 72  ? 22.495  -29.157 33.043  1.00 53.47  ? 72  ARG B N   1 
ATOM 5046  C CA  . ARG B 2 72  ? 22.028  -29.619 31.711  1.00 56.49  ? 72  ARG B CA  1 
ATOM 5047  C C   . ARG B 2 72  ? 22.993  -30.585 31.009  1.00 58.98  ? 72  ARG B C   1 
ATOM 5048  O O   . ARG B 2 72  ? 24.181  -30.267 31.025  1.00 65.16  ? 72  ARG B O   1 
ATOM 5049  C CB  . ARG B 2 72  ? 21.951  -28.355 30.854  1.00 59.82  ? 72  ARG B CB  1 
ATOM 5050  C CG  . ARG B 2 72  ? 23.140  -27.408 30.869  1.00 54.53  ? 72  ARG B CG  1 
ATOM 5051  C CD  . ARG B 2 72  ? 22.872  -26.251 29.935  1.00 48.26  ? 72  ARG B CD  1 
ATOM 5052  N NE  . ARG B 2 72  ? 21.733  -26.540 29.059  1.00 47.71  ? 72  ARG B NE  1 
ATOM 5053  C CZ  . ARG B 2 72  ? 21.062  -25.633 28.374  1.00 48.01  ? 72  ARG B CZ  1 
ATOM 5054  N NH1 . ARG B 2 72  ? 20.662  -24.523 28.956  1.00 50.93  ? 72  ARG B NH1 1 
ATOM 5055  N NH2 . ARG B 2 72  ? 20.784  -25.844 27.105  1.00 46.94  ? 72  ARG B NH2 1 
ATOM 5056  N N   . ASP B 2 73  ? 22.572  -31.760 30.522  1.00 62.06  ? 73  ASP B N   1 
ATOM 5057  C CA  . ASP B 2 73  ? 23.425  -32.626 29.637  1.00 62.93  ? 73  ASP B CA  1 
ATOM 5058  C C   . ASP B 2 73  ? 23.759  -32.019 28.267  1.00 63.44  ? 73  ASP B C   1 
ATOM 5059  O O   . ASP B 2 73  ? 24.903  -32.174 27.821  1.00 60.41  ? 73  ASP B O   1 
ATOM 5060  C CB  . ASP B 2 73  ? 22.866  -34.022 29.448  1.00 66.81  ? 73  ASP B CB  1 
ATOM 5061  C CG  . ASP B 2 73  ? 23.909  -35.114 29.269  1.00 71.72  ? 73  ASP B CG  1 
ATOM 5062  O OD1 . ASP B 2 73  ? 24.728  -34.993 28.341  1.00 70.65  ? 73  ASP B OD1 1 
ATOM 5063  O OD2 . ASP B 2 73  ? 23.894  -36.074 30.060  1.00 75.62  ? 73  ASP B OD2 1 
ATOM 5064  N N   . ASN B 2 74  ? 22.794  -31.374 27.617  1.00 63.29  ? 74  ASN B N   1 
ATOM 5065  C CA  . ASN B 2 74  ? 22.958  -30.792 26.250  1.00 68.77  ? 74  ASN B CA  1 
ATOM 5066  C C   . ASN B 2 74  ? 22.993  -31.875 25.156  1.00 66.64  ? 74  ASN B C   1 
ATOM 5067  O O   . ASN B 2 74  ? 22.165  -31.813 24.237  1.00 56.68  ? 74  ASN B O   1 
ATOM 5068  C CB  . ASN B 2 74  ? 24.125  -29.815 26.183  1.00 70.25  ? 74  ASN B CB  1 
ATOM 5069  C CG  . ASN B 2 74  ? 23.706  -28.394 26.457  1.00 69.39  ? 74  ASN B CG  1 
ATOM 5070  O OD1 . ASN B 2 74  ? 22.513  -28.080 26.416  1.00 70.57  ? 74  ASN B OD1 1 
ATOM 5071  N ND2 . ASN B 2 74  ? 24.665  -27.528 26.741  1.00 69.77  ? 74  ASN B ND2 1 
ATOM 5072  N N   . ALA B 2 75  ? 23.909  -32.831 25.232  1.00 73.12  ? 75  ALA B N   1 
ATOM 5073  C CA  . ALA B 2 75  ? 23.942  -33.937 24.246  1.00 69.79  ? 75  ALA B CA  1 
ATOM 5074  C C   . ALA B 2 75  ? 22.651  -34.712 24.404  1.00 66.00  ? 75  ALA B C   1 
ATOM 5075  O O   . ALA B 2 75  ? 21.951  -34.991 23.423  1.00 73.18  ? 75  ALA B O   1 
ATOM 5076  C CB  . ALA B 2 75  ? 25.116  -34.819 24.545  1.00 62.13  ? 75  ALA B CB  1 
ATOM 5077  N N   . LYS B 2 76  ? 22.386  -35.090 25.626  1.00 59.68  ? 76  LYS B N   1 
ATOM 5078  C CA  . LYS B 2 76  ? 21.125  -35.769 26.009  1.00 63.40  ? 76  LYS B CA  1 
ATOM 5079  C C   . LYS B 2 76  ? 19.944  -34.918 25.529  1.00 62.00  ? 76  LYS B C   1 
ATOM 5080  O O   . LYS B 2 76  ? 18.938  -35.524 25.134  1.00 54.59  ? 76  LYS B O   1 
ATOM 5081  C CB  . LYS B 2 76  ? 21.167  -36.186 27.481  1.00 70.36  ? 76  LYS B CB  1 
ATOM 5082  C CG  . LYS B 2 76  ? 21.598  -37.626 27.706  1.00 75.98  ? 76  LYS B CG  1 
ATOM 5083  C CD  . LYS B 2 76  ? 21.276  -38.149 29.099  1.00 85.12  ? 76  LYS B CD  1 
ATOM 5084  C CE  . LYS B 2 76  ? 20.165  -39.150 29.093  1.00 96.42  ? 76  LYS B CE  1 
ATOM 5085  N NZ  . LYS B 2 76  ? 20.323  -40.164 30.139  1.00 100.28 ? 76  LYS B NZ  1 
ATOM 5086  N N   . ASN B 2 77  ? 20.049  -33.585 25.603  1.00 61.91  ? 77  ASN B N   1 
ATOM 5087  C CA  . ASN B 2 77  ? 18.869  -32.712 25.342  1.00 67.39  ? 77  ASN B CA  1 
ATOM 5088  C C   . ASN B 2 77  ? 17.984  -32.711 26.588  1.00 64.03  ? 77  ASN B C   1 
ATOM 5089  O O   . ASN B 2 77  ? 16.794  -32.408 26.458  1.00 55.60  ? 77  ASN B O   1 
ATOM 5090  C CB  . ASN B 2 77  ? 18.165  -33.051 24.036  1.00 72.38  ? 77  ASN B CB  1 
ATOM 5091  C CG  . ASN B 2 77  ? 18.628  -32.207 22.875  1.00 76.43  ? 77  ASN B CG  1 
ATOM 5092  O OD1 . ASN B 2 77  ? 19.812  -31.874 22.776  1.00 85.22  ? 77  ASN B OD1 1 
ATOM 5093  N ND2 . ASN B 2 77  ? 17.717  -31.869 21.976  1.00 75.80  ? 77  ASN B ND2 1 
ATOM 5094  N N   . THR B 2 78  ? 18.545  -33.111 27.731  1.00 60.56  ? 78  THR B N   1 
ATOM 5095  C CA  . THR B 2 78  ? 17.807  -33.171 29.010  1.00 57.12  ? 78  THR B CA  1 
ATOM 5096  C C   . THR B 2 78  ? 18.293  -32.136 30.008  1.00 49.86  ? 78  THR B C   1 
ATOM 5097  O O   . THR B 2 78  ? 19.509  -31.941 30.095  1.00 40.51  ? 78  THR B O   1 
ATOM 5098  C CB  . THR B 2 78  ? 17.957  -34.577 29.577  1.00 55.52  ? 78  THR B CB  1 
ATOM 5099  O OG1 . THR B 2 78  ? 19.346  -34.681 29.862  1.00 59.44  ? 78  THR B OG1 1 
ATOM 5100  C CG2 . THR B 2 78  ? 17.528  -35.651 28.596  1.00 51.40  ? 78  THR B CG2 1 
ATOM 5101  N N   . LEU B 2 79  ? 17.373  -31.396 30.633  1.00 51.07  ? 79  LEU B N   1 
ATOM 5102  C CA  . LEU B 2 79  ? 17.720  -30.442 31.720  1.00 58.16  ? 79  LEU B CA  1 
ATOM 5103  C C   . LEU B 2 79  ? 17.375  -31.088 33.066  1.00 56.17  ? 79  LEU B C   1 
ATOM 5104  O O   . LEU B 2 79  ? 16.347  -31.758 33.136  1.00 61.20  ? 79  LEU B O   1 
ATOM 5105  C CB  . LEU B 2 79  ? 16.958  -29.129 31.559  1.00 57.85  ? 79  LEU B CB  1 
ATOM 5106  C CG  . LEU B 2 79  ? 17.043  -28.137 32.719  1.00 55.69  ? 79  LEU B CG  1 
ATOM 5107  C CD1 . LEU B 2 79  ? 18.413  -27.499 32.741  1.00 54.48  ? 79  LEU B CD1 1 
ATOM 5108  C CD2 . LEU B 2 79  ? 15.965  -27.086 32.560  1.00 53.23  ? 79  LEU B CD2 1 
ATOM 5109  N N   . TYR B 2 80  ? 18.195  -30.874 34.091  1.00 53.13  ? 80  TYR B N   1 
ATOM 5110  C CA  . TYR B 2 80  ? 17.942  -31.481 35.382  1.00 54.19  ? 80  TYR B CA  1 
ATOM 5111  C C   . TYR B 2 80  ? 17.613  -30.421 36.426  1.00 54.09  ? 80  TYR B C   1 
ATOM 5112  O O   . TYR B 2 80  ? 17.900  -29.226 36.242  1.00 51.41  ? 80  TYR B O   1 
ATOM 5113  C CB  . TYR B 2 80  ? 19.187  -32.237 35.835  1.00 55.49  ? 80  TYR B CB  1 
ATOM 5114  C CG  . TYR B 2 80  ? 19.657  -33.318 34.879  1.00 57.55  ? 80  TYR B CG  1 
ATOM 5115  C CD1 . TYR B 2 80  ? 18.802  -34.322 34.443  1.00 55.57  ? 80  TYR B CD1 1 
ATOM 5116  C CD2 . TYR B 2 80  ? 20.967  -33.319 34.411  1.00 63.81  ? 80  TYR B CD2 1 
ATOM 5117  C CE1 . TYR B 2 80  ? 19.249  -35.304 33.574  1.00 55.51  ? 80  TYR B CE1 1 
ATOM 5118  C CE2 . TYR B 2 80  ? 21.423  -34.296 33.544  1.00 59.85  ? 80  TYR B CE2 1 
ATOM 5119  C CZ  . TYR B 2 80  ? 20.562  -35.291 33.129  1.00 56.86  ? 80  TYR B CZ  1 
ATOM 5120  O OH  . TYR B 2 80  ? 21.083  -36.217 32.275  1.00 59.30  ? 80  TYR B OH  1 
ATOM 5121  N N   . LEU B 2 81  ? 17.014  -30.913 37.520  1.00 49.62  ? 81  LEU B N   1 
ATOM 5122  C CA  . LEU B 2 81  ? 16.920  -30.179 38.770  1.00 50.86  ? 81  LEU B CA  1 
ATOM 5123  C C   . LEU B 2 81  ? 17.051  -31.144 39.939  1.00 47.37  ? 81  LEU B C   1 
ATOM 5124  O O   . LEU B 2 81  ? 16.092  -31.849 40.232  1.00 41.29  ? 81  LEU B O   1 
ATOM 5125  C CB  . LEU B 2 81  ? 15.580  -29.456 38.833  1.00 53.55  ? 81  LEU B CB  1 
ATOM 5126  C CG  . LEU B 2 81  ? 15.330  -28.607 40.081  1.00 54.59  ? 81  LEU B CG  1 
ATOM 5127  C CD1 . LEU B 2 81  ? 16.390  -27.526 40.253  1.00 54.25  ? 81  LEU B CD1 1 
ATOM 5128  C CD2 . LEU B 2 81  ? 13.934  -28.003 40.014  1.00 53.13  ? 81  LEU B CD2 1 
ATOM 5129  N N   . GLN B 2 82  ? 18.222  -31.133 40.598  1.00 52.56  ? 82  GLN B N   1 
ATOM 5130  C CA  . GLN B 2 82  ? 18.485  -31.953 41.775  1.00 55.25  ? 82  GLN B CA  1 
ATOM 5131  C C   . GLN B 2 82  ? 17.993  -31.244 43.037  1.00 59.22  ? 82  GLN B C   1 
ATOM 5132  O O   . GLN B 2 82  ? 18.558  -30.223 43.427  1.00 66.33  ? 82  GLN B O   1 
ATOM 5133  C CB  . GLN B 2 82  ? 19.979  -32.233 41.948  1.00 53.62  ? 82  GLN B CB  1 
ATOM 5134  C CG  . GLN B 2 82  ? 20.300  -33.208 43.075  1.00 52.08  ? 82  GLN B CG  1 
ATOM 5135  C CD  . GLN B 2 82  ? 19.631  -34.546 42.870  1.00 53.15  ? 82  GLN B CD  1 
ATOM 5136  O OE1 . GLN B 2 82  ? 18.781  -34.958 43.668  1.00 55.63  ? 82  GLN B OE1 1 
ATOM 5137  N NE2 . GLN B 2 82  ? 19.979  -35.213 41.775  1.00 51.43  ? 82  GLN B NE2 1 
ATOM 5138  N N   . MET B 2 83  ? 16.969  -31.825 43.678  1.00 57.90  ? 83  MET B N   1 
ATOM 5139  C CA  . MET B 2 83  ? 16.311  -31.244 44.840  1.00 64.68  ? 83  MET B CA  1 
ATOM 5140  C C   . MET B 2 83  ? 16.736  -32.002 46.100  1.00 61.80  ? 83  MET B C   1 
ATOM 5141  O O   . MET B 2 83  ? 16.612  -33.221 46.172  1.00 62.20  ? 83  MET B O   1 
ATOM 5142  C CB  . MET B 2 83  ? 14.785  -31.315 44.673  1.00 66.30  ? 83  MET B CB  1 
ATOM 5143  C CG  . MET B 2 83  ? 14.297  -30.984 43.267  1.00 65.06  ? 83  MET B CG  1 
ATOM 5144  S SD  . MET B 2 83  ? 12.510  -31.140 43.070  1.00 72.55  ? 83  MET B SD  1 
ATOM 5145  C CE  . MET B 2 83  ? 11.950  -29.548 43.695  1.00 74.09  ? 83  MET B CE  1 
ATOM 5146  N N   . ASN B 2 84  ? 17.253  -31.285 47.100  1.00 59.27  ? 84  ASN B N   1 
ATOM 5147  C CA  . ASN B 2 84  ? 17.683  -31.933 48.328  1.00 59.65  ? 84  ASN B CA  1 
ATOM 5148  C C   . ASN B 2 84  ? 16.990  -31.279 49.517  1.00 65.49  ? 84  ASN B C   1 
ATOM 5149  O O   . ASN B 2 84  ? 16.407  -30.206 49.376  1.00 73.64  ? 84  ASN B O   1 
ATOM 5150  C CB  . ASN B 2 84  ? 19.193  -31.894 48.502  1.00 54.23  ? 84  ASN B CB  1 
ATOM 5151  C CG  . ASN B 2 84  ? 19.909  -32.461 47.308  1.00 56.85  ? 84  ASN B CG  1 
ATOM 5152  O OD1 . ASN B 2 84  ? 20.701  -31.750 46.683  1.00 69.72  ? 84  ASN B OD1 1 
ATOM 5153  N ND2 . ASN B 2 84  ? 19.648  -33.717 46.970  1.00 57.24  ? 84  ASN B ND2 1 
ATOM 5154  N N   . SER B 2 85  ? 17.034  -31.966 50.669  1.00 62.01  ? 85  SER B N   1 
ATOM 5155  C CA  . SER B 2 85  ? 16.569  -31.419 51.932  1.00 52.93  ? 85  SER B CA  1 
ATOM 5156  C C   . SER B 2 85  ? 15.168  -30.823 51.761  1.00 48.30  ? 85  SER B C   1 
ATOM 5157  O O   . SER B 2 85  ? 14.843  -29.761 52.289  1.00 42.61  ? 85  SER B O   1 
ATOM 5158  C CB  . SER B 2 85  ? 17.577  -30.412 52.447  1.00 52.04  ? 85  SER B CB  1 
ATOM 5159  O OG  . SER B 2 85  ? 18.905  -30.914 52.372  1.00 46.03  ? 85  SER B OG  1 
ATOM 5160  N N   . LEU B 2 86  ? 14.324  -31.534 51.013  1.00 49.70  ? 86  LEU B N   1 
ATOM 5161  C CA  . LEU B 2 86  ? 13.013  -31.024 50.659  1.00 55.27  ? 86  LEU B CA  1 
ATOM 5162  C C   . LEU B 2 86  ? 12.255  -30.631 51.924  1.00 61.85  ? 86  LEU B C   1 
ATOM 5163  O O   . LEU B 2 86  ? 12.441  -31.237 52.982  1.00 69.37  ? 86  LEU B O   1 
ATOM 5164  C CB  . LEU B 2 86  ? 12.239  -32.052 49.832  1.00 55.55  ? 86  LEU B CB  1 
ATOM 5165  C CG  . LEU B 2 86  ? 12.719  -32.265 48.391  1.00 58.75  ? 86  LEU B CG  1 
ATOM 5166  C CD1 . LEU B 2 86  ? 11.816  -33.260 47.704  1.00 61.22  ? 86  LEU B CD1 1 
ATOM 5167  C CD2 . LEU B 2 86  ? 12.778  -30.994 47.560  1.00 57.37  ? 86  LEU B CD2 1 
ATOM 5168  N N   . LYS B 2 87  ? 11.419  -29.590 51.781  1.00 66.12  ? 87  LYS B N   1 
ATOM 5169  C CA  . LYS B 2 87  ? 10.559  -29.081 52.837  1.00 66.01  ? 87  LYS B CA  1 
ATOM 5170  C C   . LYS B 2 87  ? 9.132   -29.083 52.298  1.00 61.01  ? 87  LYS B C   1 
ATOM 5171  O O   . LYS B 2 87  ? 8.939   -28.921 51.101  1.00 56.83  ? 87  LYS B O   1 
ATOM 5172  C CB  . LYS B 2 87  ? 11.059  -27.684 53.238  1.00 75.33  ? 87  LYS B CB  1 
ATOM 5173  C CG  . LYS B 2 87  ? 11.312  -27.460 54.735  1.00 91.52  ? 87  LYS B CG  1 
ATOM 5174  C CD  . LYS B 2 87  ? 12.476  -28.223 55.376  1.00 95.85  ? 87  LYS B CD  1 
ATOM 5175  C CE  . LYS B 2 87  ? 12.159  -29.642 55.775  1.00 92.67  ? 87  LYS B CE  1 
ATOM 5176  N NZ  . LYS B 2 87  ? 13.229  -30.268 56.552  1.00 91.47  ? 87  LYS B NZ  1 
ATOM 5177  N N   . PRO B 2 88  ? 8.088   -29.287 53.135  1.00 68.83  ? 88  PRO B N   1 
ATOM 5178  C CA  . PRO B 2 88  ? 6.696   -29.208 52.672  1.00 64.49  ? 88  PRO B CA  1 
ATOM 5179  C C   . PRO B 2 88  ? 6.367   -27.951 51.866  1.00 62.05  ? 88  PRO B C   1 
ATOM 5180  O O   . PRO B 2 88  ? 5.498   -27.996 50.998  1.00 50.34  ? 88  PRO B O   1 
ATOM 5181  C CB  . PRO B 2 88  ? 5.891   -29.259 53.979  1.00 67.08  ? 88  PRO B CB  1 
ATOM 5182  C CG  . PRO B 2 88  ? 6.780   -30.030 54.935  1.00 73.47  ? 88  PRO B CG  1 
ATOM 5183  C CD  . PRO B 2 88  ? 8.195   -29.609 54.570  1.00 74.67  ? 88  PRO B CD  1 
ATOM 5184  N N   . GLU B 2 89  ? 7.060   -26.843 52.197  1.00 70.43  ? 89  GLU B N   1 
ATOM 5185  C CA  . GLU B 2 89  ? 7.008   -25.572 51.478  1.00 70.20  ? 89  GLU B CA  1 
ATOM 5186  C C   . GLU B 2 89  ? 7.051   -25.800 49.966  1.00 62.74  ? 89  GLU B C   1 
ATOM 5187  O O   . GLU B 2 89  ? 6.191   -25.301 49.241  1.00 62.62  ? 89  GLU B O   1 
ATOM 5188  C CB  . GLU B 2 89  ? 8.193   -24.662 51.825  1.00 75.85  ? 89  GLU B CB  1 
ATOM 5189  C CG  . GLU B 2 89  ? 8.469   -24.493 53.316  1.00 88.84  ? 89  GLU B CG  1 
ATOM 5190  C CD  . GLU B 2 89  ? 7.256   -24.103 54.139  1.00 107.48 ? 89  GLU B CD  1 
ATOM 5191  O OE1 . GLU B 2 89  ? 6.664   -23.027 53.880  1.00 130.43 ? 89  GLU B OE1 1 
ATOM 5192  O OE2 . GLU B 2 89  ? 6.913   -24.896 55.044  1.00 111.39 ? 89  GLU B OE2 1 
ATOM 5193  N N   . ASP B 2 90  ? 8.044   -26.596 49.535  1.00 52.70  ? 90  ASP B N   1 
ATOM 5194  C CA  . ASP B 2 90  ? 8.431   -26.773 48.145  1.00 48.72  ? 90  ASP B CA  1 
ATOM 5195  C C   . ASP B 2 90  ? 7.390   -27.569 47.350  1.00 51.18  ? 90  ASP B C   1 
ATOM 5196  O O   . ASP B 2 90  ? 7.633   -27.911 46.190  1.00 49.62  ? 90  ASP B O   1 
ATOM 5197  C CB  . ASP B 2 90  ? 9.776   -27.481 48.056  1.00 48.98  ? 90  ASP B CB  1 
ATOM 5198  C CG  . ASP B 2 90  ? 10.934  -26.832 48.803  1.00 49.57  ? 90  ASP B CG  1 
ATOM 5199  O OD1 . ASP B 2 90  ? 11.122  -25.607 48.661  1.00 55.51  ? 90  ASP B OD1 1 
ATOM 5200  O OD2 . ASP B 2 90  ? 11.659  -27.556 49.501  1.00 43.75  ? 90  ASP B OD2 1 
ATOM 5201  N N   . THR B 2 91  ? 6.237   -27.864 47.959  1.00 52.85  ? 91  THR B N   1 
ATOM 5202  C CA  . THR B 2 91  ? 5.172   -28.680 47.318  1.00 50.77  ? 91  THR B CA  1 
ATOM 5203  C C   . THR B 2 91  ? 4.497   -27.877 46.247  1.00 49.54  ? 91  THR B C   1 
ATOM 5204  O O   . THR B 2 91  ? 3.579   -27.131 46.571  1.00 57.39  ? 91  THR B O   1 
ATOM 5205  C CB  . THR B 2 91  ? 4.158   -29.137 48.359  1.00 45.67  ? 91  THR B CB  1 
ATOM 5206  O OG1 . THR B 2 91  ? 4.893   -30.004 49.214  1.00 51.72  ? 91  THR B OG1 1 
ATOM 5207  C CG2 . THR B 2 91  ? 2.978   -29.863 47.743  1.00 40.42  ? 91  THR B CG2 1 
ATOM 5208  N N   . ALA B 2 92  ? 5.023   -27.932 45.035  1.00 43.66  ? 92  ALA B N   1 
ATOM 5209  C CA  . ALA B 2 92  ? 4.457   -27.163 43.921  1.00 42.92  ? 92  ALA B CA  1 
ATOM 5210  C C   . ALA B 2 92  ? 4.515   -27.945 42.627  1.00 43.15  ? 92  ALA B C   1 
ATOM 5211  O O   . ALA B 2 92  ? 5.282   -28.894 42.553  1.00 42.57  ? 92  ALA B O   1 
ATOM 5212  C CB  . ALA B 2 92  ? 5.280   -25.936 43.783  1.00 44.49  ? 92  ALA B CB  1 
ATOM 5213  N N   . ARG B 2 93  ? 3.644   -27.631 41.681  1.00 47.69  ? 93  ARG B N   1 
ATOM 5214  C CA  . ARG B 2 93  ? 3.827   -28.198 40.330  1.00 54.60  ? 93  ARG B CA  1 
ATOM 5215  C C   . ARG B 2 93  ? 5.113   -27.571 39.796  1.00 52.79  ? 93  ARG B C   1 
ATOM 5216  O O   . ARG B 2 93  ? 5.288   -26.362 39.977  1.00 55.53  ? 93  ARG B O   1 
ATOM 5217  C CB  . ARG B 2 93  ? 2.713   -27.863 39.339  1.00 62.72  ? 93  ARG B CB  1 
ATOM 5218  C CG  . ARG B 2 93  ? 2.856   -28.609 38.021  1.00 71.28  ? 93  ARG B CG  1 
ATOM 5219  C CD  . ARG B 2 93  ? 1.569   -28.628 37.229  1.00 85.07  ? 93  ARG B CD  1 
ATOM 5220  N NE  . ARG B 2 93  ? 0.594   -29.569 37.788  1.00 91.16  ? 93  ARG B NE  1 
ATOM 5221  C CZ  . ARG B 2 93  ? 0.412   -30.805 37.351  1.00 91.60  ? 93  ARG B CZ  1 
ATOM 5222  N NH1 . ARG B 2 93  ? 0.941   -31.184 36.202  1.00 83.18  ? 93  ARG B NH1 1 
ATOM 5223  N NH2 . ARG B 2 93  ? -0.300  -31.658 38.065  1.00 94.05  ? 93  ARG B NH2 1 
ATOM 5224  N N   . TYR B 2 94  ? 5.930   -28.342 39.096  1.00 50.96  ? 94  TYR B N   1 
ATOM 5225  C CA  . TYR B 2 94  ? 7.222   -27.811 38.614  1.00 50.36  ? 94  TYR B CA  1 
ATOM 5226  C C   . TYR B 2 94  ? 7.121   -27.762 37.124  1.00 53.54  ? 94  TYR B C   1 
ATOM 5227  O O   . TYR B 2 94  ? 6.463   -28.635 36.563  1.00 56.08  ? 94  TYR B O   1 
ATOM 5228  C CB  . TYR B 2 94  ? 8.427   -28.551 39.193  1.00 49.77  ? 94  TYR B CB  1 
ATOM 5229  C CG  . TYR B 2 94  ? 8.782   -28.155 40.618  1.00 53.82  ? 94  TYR B CG  1 
ATOM 5230  C CD1 . TYR B 2 94  ? 7.992   -28.555 41.683  1.00 55.06  ? 94  TYR B CD1 1 
ATOM 5231  C CD2 . TYR B 2 94  ? 9.905   -27.392 40.897  1.00 55.02  ? 94  TYR B CD2 1 
ATOM 5232  C CE1 . TYR B 2 94  ? 8.298   -28.204 42.984  1.00 52.91  ? 94  TYR B CE1 1 
ATOM 5233  C CE2 . TYR B 2 94  ? 10.225  -27.036 42.195  1.00 55.87  ? 94  TYR B CE2 1 
ATOM 5234  C CZ  . TYR B 2 94  ? 9.418   -27.441 43.241  1.00 53.91  ? 94  TYR B CZ  1 
ATOM 5235  O OH  . TYR B 2 94  ? 9.712   -27.106 44.526  1.00 53.10  ? 94  TYR B OH  1 
ATOM 5236  N N   . TYR B 2 95  ? 7.783   -26.798 36.506  1.00 57.60  ? 95  TYR B N   1 
ATOM 5237  C CA  . TYR B 2 95  ? 7.641   -26.501 35.093  1.00 52.09  ? 95  TYR B CA  1 
ATOM 5238  C C   . TYR B 2 95  ? 9.002   -26.157 34.484  1.00 55.05  ? 95  TYR B C   1 
ATOM 5239  O O   . TYR B 2 95  ? 9.862   -25.557 35.136  1.00 50.47  ? 95  TYR B O   1 
ATOM 5240  C CB  . TYR B 2 95  ? 6.734   -25.286 34.934  1.00 46.18  ? 95  TYR B CB  1 
ATOM 5241  C CG  . TYR B 2 95  ? 5.233   -25.499 35.002  1.00 47.73  ? 95  TYR B CG  1 
ATOM 5242  C CD1 . TYR B 2 95  ? 4.544   -26.037 33.928  1.00 49.73  ? 95  TYR B CD1 1 
ATOM 5243  C CD2 . TYR B 2 95  ? 4.483   -25.030 36.073  1.00 53.24  ? 95  TYR B CD2 1 
ATOM 5244  C CE1 . TYR B 2 95  ? 3.164   -26.166 33.939  1.00 49.79  ? 95  TYR B CE1 1 
ATOM 5245  C CE2 . TYR B 2 95  ? 3.099   -25.150 36.099  1.00 52.61  ? 95  TYR B CE2 1 
ATOM 5246  C CZ  . TYR B 2 95  ? 2.436   -25.718 35.024  1.00 50.04  ? 95  TYR B CZ  1 
ATOM 5247  O OH  . TYR B 2 95  ? 1.078   -25.855 35.002  1.00 51.71  ? 95  TYR B OH  1 
ATOM 5248  N N   . CYS B 2 96  ? 9.150   -26.509 33.202  1.00 60.38  ? 96  CYS B N   1 
ATOM 5249  C CA  . CYS B 2 96  ? 10.356  -26.271 32.428  1.00 64.39  ? 96  CYS B CA  1 
ATOM 5250  C C   . CYS B 2 96  ? 10.084  -25.157 31.420  1.00 62.38  ? 96  CYS B C   1 
ATOM 5251  O O   . CYS B 2 96  ? 8.995   -25.083 30.849  1.00 68.10  ? 96  CYS B O   1 
ATOM 5252  C CB  . CYS B 2 96  ? 10.781  -27.552 31.720  1.00 73.01  ? 96  CYS B CB  1 
ATOM 5253  S SG  . CYS B 2 96  ? 12.364  -27.403 30.861  1.00 89.97  ? 96  CYS B SG  1 
ATOM 5254  N N   . ALA B 2 97  ? 11.070  -24.274 31.232  1.00 57.18  ? 97  ALA B N   1 
ATOM 5255  C CA  . ALA B 2 97  ? 10.924  -23.151 30.322  1.00 56.24  ? 97  ALA B CA  1 
ATOM 5256  C C   . ALA B 2 97  ? 12.213  -22.946 29.535  1.00 58.97  ? 97  ALA B C   1 
ATOM 5257  O O   . ALA B 2 97  ? 13.312  -23.200 30.041  1.00 50.37  ? 97  ALA B O   1 
ATOM 5258  C CB  . ALA B 2 97  ? 10.557  -21.898 31.084  1.00 56.74  ? 97  ALA B CB  1 
ATOM 5259  N N   . ALA B 2 98  ? 12.040  -22.438 28.304  1.00 62.11  ? 98  ALA B N   1 
ATOM 5260  C CA  . ALA B 2 98  ? 13.136  -22.183 27.381  1.00 59.99  ? 98  ALA B CA  1 
ATOM 5261  C C   . ALA B 2 98  ? 12.995  -20.793 26.754  1.00 57.39  ? 98  ALA B C   1 
ATOM 5262  O O   . ALA B 2 98  ? 11.928  -20.402 26.271  1.00 54.11  ? 98  ALA B O   1 
ATOM 5263  C CB  . ALA B 2 98  ? 13.151  -23.272 26.336  1.00 62.23  ? 98  ALA B CB  1 
ATOM 5264  N N   . GLY B 2 99  ? 14.101  -20.045 26.763  1.00 52.81  ? 99  GLY B N   1 
ATOM 5265  C CA  . GLY B 2 99  ? 14.090  -18.659 26.326  1.00 51.98  ? 99  GLY B CA  1 
ATOM 5266  C C   . GLY B 2 99  ? 15.493  -18.221 25.917  1.00 51.45  ? 99  GLY B C   1 
ATOM 5267  O O   . GLY B 2 99  ? 16.355  -19.077 25.667  1.00 41.70  ? 99  GLY B O   1 
ATOM 5268  N N   . SER B 2 100 ? 15.682  -16.888 25.864  1.00 50.15  ? 100 SER B N   1 
ATOM 5269  C CA  . SER B 2 100 ? 16.833  -16.278 25.214  1.00 52.53  ? 100 SER B CA  1 
ATOM 5270  C C   . SER B 2 100 ? 17.749  -15.605 26.226  1.00 55.70  ? 100 SER B C   1 
ATOM 5271  O O   . SER B 2 100 ? 18.840  -15.176 25.844  1.00 50.38  ? 100 SER B O   1 
ATOM 5272  C CB  . SER B 2 100 ? 16.395  -15.280 24.183  1.00 55.22  ? 100 SER B CB  1 
ATOM 5273  O OG  . SER B 2 100 ? 15.569  -14.277 24.767  1.00 58.02  ? 100 SER B OG  1 
ATOM 5274  N N   . THR B 2 101 ? 17.290  -15.545 27.490  1.00 66.24  ? 101 THR B N   1 
ATOM 5275  C CA  . THR B 2 101 ? 17.916  -14.776 28.562  1.00 70.92  ? 101 THR B CA  1 
ATOM 5276  C C   . THR B 2 101 ? 17.992  -15.623 29.840  1.00 71.74  ? 101 THR B C   1 
ATOM 5277  O O   . THR B 2 101 ? 17.288  -16.627 29.982  1.00 75.58  ? 101 THR B O   1 
ATOM 5278  C CB  . THR B 2 101 ? 17.110  -13.495 28.797  1.00 71.14  ? 101 THR B CB  1 
ATOM 5279  O OG1 . THR B 2 101 ? 15.741  -13.883 28.858  1.00 87.64  ? 101 THR B OG1 1 
ATOM 5280  C CG2 . THR B 2 101 ? 17.223  -12.496 27.662  1.00 73.11  ? 101 THR B CG2 1 
ATOM 5281  N N   . LEU B 2 102 ? 18.833  -15.182 30.788  1.00 67.31  ? 102 LEU B N   1 
ATOM 5282  C CA  . LEU B 2 102 ? 18.925  -15.778 32.115  1.00 60.95  ? 102 LEU B CA  1 
ATOM 5283  C C   . LEU B 2 102 ? 18.064  -14.994 33.109  1.00 60.73  ? 102 LEU B C   1 
ATOM 5284  O O   . LEU B 2 102 ? 18.503  -14.709 34.221  1.00 55.95  ? 102 LEU B O   1 
ATOM 5285  C CB  . LEU B 2 102 ? 20.397  -15.760 32.525  1.00 60.63  ? 102 LEU B CB  1 
ATOM 5286  C CG  . LEU B 2 102 ? 20.743  -16.377 33.886  1.00 63.29  ? 102 LEU B CG  1 
ATOM 5287  C CD1 . LEU B 2 102 ? 20.624  -17.887 33.811  1.00 66.75  ? 102 LEU B CD1 1 
ATOM 5288  C CD2 . LEU B 2 102 ? 22.123  -15.972 34.386  1.00 65.24  ? 102 LEU B CD2 1 
ATOM 5289  N N   . THR B 2 103 ? 16.834  -14.636 32.715  1.00 69.43  ? 103 THR B N   1 
ATOM 5290  C CA  . THR B 2 103 ? 15.989  -13.784 33.544  1.00 74.12  ? 103 THR B CA  1 
ATOM 5291  C C   . THR B 2 103 ? 14.895  -14.653 34.163  1.00 71.97  ? 103 THR B C   1 
ATOM 5292  O O   . THR B 2 103 ? 14.654  -15.775 33.715  1.00 68.83  ? 103 THR B O   1 
ATOM 5293  C CB  . THR B 2 103 ? 15.446  -12.607 32.721  1.00 76.78  ? 103 THR B CB  1 
ATOM 5294  O OG1 . THR B 2 103 ? 15.635  -11.405 33.469  1.00 70.51  ? 103 THR B OG1 1 
ATOM 5295  C CG2 . THR B 2 103 ? 13.991  -12.759 32.311  1.00 71.91  ? 103 THR B CG2 1 
ATOM 5296  N N   . MET B 2 104 ? 14.251  -14.124 35.212  1.00 68.12  ? 104 MET B N   1 
ATOM 5297  C CA  . MET B 2 104 ? 13.306  -14.897 36.001  1.00 60.26  ? 104 MET B CA  1 
ATOM 5298  C C   . MET B 2 104 ? 11.888  -14.427 35.759  1.00 54.97  ? 104 MET B C   1 
ATOM 5299  O O   . MET B 2 104 ? 11.075  -14.498 36.664  1.00 57.21  ? 104 MET B O   1 
ATOM 5300  C CB  . MET B 2 104 ? 13.597  -14.780 37.494  1.00 54.36  ? 104 MET B CB  1 
ATOM 5301  C CG  . MET B 2 104 ? 14.926  -15.364 37.783  1.00 59.95  ? 104 MET B CG  1 
ATOM 5302  S SD  . MET B 2 104 ? 15.170  -15.796 39.505  1.00 80.31  ? 104 MET B SD  1 
ATOM 5303  C CE  . MET B 2 104 ? 14.169  -17.277 39.657  1.00 76.05  ? 104 MET B CE  1 
ATOM 5304  N N   . VAL B 2 105 ? 11.597  -14.051 34.517  1.00 54.07  ? 105 VAL B N   1 
ATOM 5305  C CA  . VAL B 2 105 ? 10.321  -13.463 34.181  1.00 54.52  ? 105 VAL B CA  1 
ATOM 5306  C C   . VAL B 2 105 ? 9.562   -14.443 33.301  1.00 56.16  ? 105 VAL B C   1 
ATOM 5307  O O   . VAL B 2 105 ? 10.085  -14.888 32.279  1.00 53.87  ? 105 VAL B O   1 
ATOM 5308  C CB  . VAL B 2 105 ? 10.504  -12.121 33.456  1.00 54.77  ? 105 VAL B CB  1 
ATOM 5309  C CG1 . VAL B 2 105 ? 9.153   -11.465 33.228  1.00 62.10  ? 105 VAL B CG1 1 
ATOM 5310  C CG2 . VAL B 2 105 ? 11.431  -11.177 34.207  1.00 49.53  ? 105 VAL B CG2 1 
ATOM 5311  N N   . VAL B 2 106 ? 8.317   -14.722 33.695  1.00 59.03  ? 106 VAL B N   1 
ATOM 5312  C CA  . VAL B 2 106 ? 7.450   -15.619 32.948  1.00 62.89  ? 106 VAL B CA  1 
ATOM 5313  C C   . VAL B 2 106 ? 7.261   -15.167 31.499  1.00 65.15  ? 106 VAL B C   1 
ATOM 5314  O O   . VAL B 2 106 ? 7.202   -16.008 30.604  1.00 75.63  ? 106 VAL B O   1 
ATOM 5315  C CB  . VAL B 2 106 ? 6.083   -15.762 33.633  1.00 60.30  ? 106 VAL B CB  1 
ATOM 5316  C CG1 . VAL B 2 106 ? 5.040   -16.331 32.676  1.00 66.04  ? 106 VAL B CG1 1 
ATOM 5317  C CG2 . VAL B 2 106 ? 6.180   -16.590 34.901  1.00 53.89  ? 106 VAL B CG2 1 
ATOM 5318  N N   . ALA B 2 107 ? 7.095   -13.859 31.265  1.00 68.75  ? 107 ALA B N   1 
ATOM 5319  C CA  . ALA B 2 107 ? 6.775   -13.365 29.928  1.00 69.05  ? 107 ALA B CA  1 
ATOM 5320  C C   . ALA B 2 107 ? 7.918   -13.612 28.944  1.00 66.65  ? 107 ALA B C   1 
ATOM 5321  O O   . ALA B 2 107 ? 7.660   -13.846 27.771  1.00 65.69  ? 107 ALA B O   1 
ATOM 5322  C CB  . ALA B 2 107 ? 6.420   -11.900 29.967  1.00 67.89  ? 107 ALA B CB  1 
ATOM 5323  N N   . ASN B 2 108 ? 9.167   -13.588 29.429  1.00 66.92  ? 108 ASN B N   1 
ATOM 5324  C CA  . ASN B 2 108 ? 10.342  -13.636 28.571  1.00 61.60  ? 108 ASN B CA  1 
ATOM 5325  C C   . ASN B 2 108 ? 10.750  -15.054 28.179  1.00 62.37  ? 108 ASN B C   1 
ATOM 5326  O O   . ASN B 2 108 ? 11.813  -15.207 27.586  1.00 73.53  ? 108 ASN B O   1 
ATOM 5327  C CB  . ASN B 2 108 ? 11.554  -13.010 29.248  1.00 64.30  ? 108 ASN B CB  1 
ATOM 5328  C CG  . ASN B 2 108 ? 11.478  -11.506 29.295  1.00 68.42  ? 108 ASN B CG  1 
ATOM 5329  O OD1 . ASN B 2 108 ? 10.439  -10.927 28.965  1.00 74.16  ? 108 ASN B OD1 1 
ATOM 5330  N ND2 . ASN B 2 108 ? 12.564  -10.861 29.702  1.00 67.54  ? 108 ASN B ND2 1 
ATOM 5331  N N   . TYR B 2 109 ? 9.967   -16.085 28.530  1.00 61.14  ? 109 TYR B N   1 
ATOM 5332  C CA  . TYR B 2 109 ? 10.239  -17.443 28.063  1.00 59.06  ? 109 TYR B CA  1 
ATOM 5333  C C   . TYR B 2 109 ? 9.174   -17.818 27.026  1.00 66.74  ? 109 TYR B C   1 
ATOM 5334  O O   . TYR B 2 109 ? 7.984   -17.591 27.253  1.00 67.62  ? 109 TYR B O   1 
ATOM 5335  C CB  . TYR B 2 109 ? 10.323  -18.421 29.241  1.00 50.49  ? 109 TYR B CB  1 
ATOM 5336  C CG  . TYR B 2 109 ? 11.571  -18.254 30.092  1.00 47.49  ? 109 TYR B CG  1 
ATOM 5337  C CD1 . TYR B 2 109 ? 12.753  -18.878 29.731  1.00 47.76  ? 109 TYR B CD1 1 
ATOM 5338  C CD2 . TYR B 2 109 ? 11.580  -17.464 31.238  1.00 45.14  ? 109 TYR B CD2 1 
ATOM 5339  C CE1 . TYR B 2 109 ? 13.911  -18.732 30.479  1.00 51.27  ? 109 TYR B CE1 1 
ATOM 5340  C CE2 . TYR B 2 109 ? 12.738  -17.292 31.985  1.00 46.98  ? 109 TYR B CE2 1 
ATOM 5341  C CZ  . TYR B 2 109 ? 13.911  -17.932 31.609  1.00 49.67  ? 109 TYR B CZ  1 
ATOM 5342  O OH  . TYR B 2 109 ? 15.084  -17.818 32.308  1.00 46.29  ? 109 TYR B OH  1 
ATOM 5343  N N   . ARG B 2 110 ? 9.611   -18.381 25.886  1.00 66.36  ? 110 ARG B N   1 
ATOM 5344  C CA  . ARG B 2 110 ? 8.737   -18.647 24.747  1.00 65.48  ? 110 ARG B CA  1 
ATOM 5345  C C   . ARG B 2 110 ? 8.077   -20.024 24.869  1.00 61.19  ? 110 ARG B C   1 
ATOM 5346  O O   . ARG B 2 110 ? 6.920   -20.213 24.484  1.00 50.61  ? 110 ARG B O   1 
ATOM 5347  C CB  . ARG B 2 110 ? 9.573   -18.547 23.465  1.00 69.59  ? 110 ARG B CB  1 
ATOM 5348  C CG  . ARG B 2 110 ? 8.805   -18.394 22.159  1.00 73.83  ? 110 ARG B CG  1 
ATOM 5349  C CD  . ARG B 2 110 ? 9.713   -18.568 20.927  1.00 78.44  ? 110 ARG B CD  1 
ATOM 5350  N NE  . ARG B 2 110 ? 9.125   -18.092 19.669  1.00 83.17  ? 110 ARG B NE  1 
ATOM 5351  C CZ  . ARG B 2 110 ? 7.891   -18.345 19.229  1.00 91.40  ? 110 ARG B CZ  1 
ATOM 5352  N NH1 . ARG B 2 110 ? 7.195   -19.363 19.711  1.00 90.92  ? 110 ARG B NH1 1 
ATOM 5353  N NH2 . ARG B 2 110 ? 7.369   -17.593 18.272  1.00 94.78  ? 110 ARG B NH2 1 
ATOM 5354  N N   . TYR B 2 111 ? 8.823   -20.992 25.415  1.00 63.72  ? 111 TYR B N   1 
ATOM 5355  C CA  . TYR B 2 111 ? 8.394   -22.378 25.400  1.00 63.02  ? 111 TYR B CA  1 
ATOM 5356  C C   . TYR B 2 111 ? 8.340   -22.956 26.809  1.00 58.44  ? 111 TYR B C   1 
ATOM 5357  O O   . TYR B 2 111 ? 9.290   -22.829 27.580  1.00 46.40  ? 111 TYR B O   1 
ATOM 5358  C CB  . TYR B 2 111 ? 9.344   -23.207 24.535  1.00 66.14  ? 111 TYR B CB  1 
ATOM 5359  C CG  . TYR B 2 111 ? 9.445   -22.767 23.079  1.00 65.51  ? 111 TYR B CG  1 
ATOM 5360  C CD1 . TYR B 2 111 ? 8.363   -22.855 22.204  1.00 60.49  ? 111 TYR B CD1 1 
ATOM 5361  C CD2 . TYR B 2 111 ? 10.652  -22.313 22.568  1.00 67.21  ? 111 TYR B CD2 1 
ATOM 5362  C CE1 . TYR B 2 111 ? 8.475   -22.470 20.880  1.00 54.34  ? 111 TYR B CE1 1 
ATOM 5363  C CE2 . TYR B 2 111 ? 10.780  -21.930 21.245  1.00 63.59  ? 111 TYR B CE2 1 
ATOM 5364  C CZ  . TYR B 2 111 ? 9.687   -22.006 20.402  1.00 56.33  ? 111 TYR B CZ  1 
ATOM 5365  O OH  . TYR B 2 111 ? 9.856   -21.590 19.121  1.00 54.01  ? 111 TYR B OH  1 
ATOM 5366  N N   . TRP B 2 112 ? 7.238   -23.669 27.070  1.00 65.24  ? 112 TRP B N   1 
ATOM 5367  C CA  . TRP B 2 112 ? 6.906   -24.181 28.386  1.00 69.36  ? 112 TRP B CA  1 
ATOM 5368  C C   . TRP B 2 112 ? 6.604   -25.677 28.336  1.00 66.87  ? 112 TRP B C   1 
ATOM 5369  O O   . TRP B 2 112 ? 6.360   -26.244 27.272  1.00 58.29  ? 112 TRP B O   1 
ATOM 5370  C CB  . TRP B 2 112 ? 5.720   -23.386 28.944  1.00 78.62  ? 112 TRP B CB  1 
ATOM 5371  C CG  . TRP B 2 112 ? 6.090   -21.982 29.356  1.00 83.50  ? 112 TRP B CG  1 
ATOM 5372  C CD1 . TRP B 2 112 ? 6.029   -20.853 28.593  1.00 78.16  ? 112 TRP B CD1 1 
ATOM 5373  C CD2 . TRP B 2 112 ? 6.591   -21.561 30.646  1.00 81.49  ? 112 TRP B CD2 1 
ATOM 5374  N NE1 . TRP B 2 112 ? 6.436   -19.766 29.318  1.00 73.93  ? 112 TRP B NE1 1 
ATOM 5375  C CE2 . TRP B 2 112 ? 6.789   -20.165 30.579  1.00 76.18  ? 112 TRP B CE2 1 
ATOM 5376  C CE3 . TRP B 2 112 ? 6.888   -22.220 31.846  1.00 81.05  ? 112 TRP B CE3 1 
ATOM 5377  C CZ2 . TRP B 2 112 ? 7.266   -19.426 31.664  1.00 78.98  ? 112 TRP B CZ2 1 
ATOM 5378  C CZ3 . TRP B 2 112 ? 7.359   -21.484 32.917  1.00 82.22  ? 112 TRP B CZ3 1 
ATOM 5379  C CH2 . TRP B 2 112 ? 7.543   -20.104 32.831  1.00 74.46  ? 112 TRP B CH2 1 
ATOM 5380  N N   . GLY B 2 113 ? 6.665   -26.308 29.517  1.00 74.68  ? 113 GLY B N   1 
ATOM 5381  C CA  . GLY B 2 113 ? 6.313   -27.709 29.695  1.00 74.18  ? 113 GLY B CA  1 
ATOM 5382  C C   . GLY B 2 113 ? 4.868   -27.858 30.174  1.00 75.89  ? 113 GLY B C   1 
ATOM 5383  O O   . GLY B 2 113 ? 4.169   -26.855 30.344  1.00 72.22  ? 113 GLY B O   1 
ATOM 5384  N N   . GLN B 2 114 ? 4.419   -29.114 30.350  1.00 71.64  ? 114 GLN B N   1 
ATOM 5385  C CA  . GLN B 2 114 ? 3.077   -29.404 30.837  1.00 67.10  ? 114 GLN B CA  1 
ATOM 5386  C C   . GLN B 2 114 ? 3.112   -29.423 32.365  1.00 60.08  ? 114 GLN B C   1 
ATOM 5387  O O   . GLN B 2 114 ? 2.104   -29.155 33.021  1.00 55.69  ? 114 GLN B O   1 
ATOM 5388  C CB  . GLN B 2 114 ? 2.518   -30.691 30.219  1.00 80.98  ? 114 GLN B CB  1 
ATOM 5389  C CG  . GLN B 2 114 ? 2.681   -31.958 31.064  1.00 99.38  ? 114 GLN B CG  1 
ATOM 5390  C CD  . GLN B 2 114 ? 4.079   -32.545 31.085  1.00 105.80 ? 114 GLN B CD  1 
ATOM 5391  O OE1 . GLN B 2 114 ? 4.905   -32.299 30.197  1.00 115.59 ? 114 GLN B OE1 1 
ATOM 5392  N NE2 . GLN B 2 114 ? 4.343   -33.370 32.092  1.00 99.13  ? 114 GLN B NE2 1 
ATOM 5393  N N   . GLY B 2 115 ? 4.283   -29.760 32.921  1.00 55.22  ? 115 GLY B N   1 
ATOM 5394  C CA  . GLY B 2 115 ? 4.518   -29.672 34.350  1.00 58.18  ? 115 GLY B CA  1 
ATOM 5395  C C   . GLY B 2 115 ? 4.333   -31.019 35.050  1.00 63.76  ? 115 GLY B C   1 
ATOM 5396  O O   . GLY B 2 115 ? 3.303   -31.681 34.869  1.00 61.21  ? 115 GLY B O   1 
ATOM 5397  N N   . THR B 2 116 ? 5.344   -31.381 35.864  1.00 66.56  ? 116 THR B N   1 
ATOM 5398  C CA  . THR B 2 116 ? 5.297   -32.513 36.785  1.00 67.94  ? 116 THR B CA  1 
ATOM 5399  C C   . THR B 2 116 ? 5.038   -31.989 38.197  1.00 66.67  ? 116 THR B C   1 
ATOM 5400  O O   . THR B 2 116 ? 5.536   -30.918 38.543  1.00 73.12  ? 116 THR B O   1 
ATOM 5401  C CB  . THR B 2 116 ? 6.609   -33.302 36.720  1.00 70.25  ? 116 THR B CB  1 
ATOM 5402  O OG1 . THR B 2 116 ? 6.370   -34.606 37.238  1.00 79.85  ? 116 THR B OG1 1 
ATOM 5403  C CG2 . THR B 2 116 ? 7.737   -32.679 37.525  1.00 67.23  ? 116 THR B CG2 1 
ATOM 5404  N N   . LEU B 2 117 ? 4.284   -32.768 38.995  1.00 58.03  ? 117 LEU B N   1 
ATOM 5405  C CA  . LEU B 2 117 ? 3.860   -32.374 40.333  1.00 50.19  ? 117 LEU B CA  1 
ATOM 5406  C C   . LEU B 2 117 ? 4.814   -32.942 41.381  1.00 48.66  ? 117 LEU B C   1 
ATOM 5407  O O   . LEU B 2 117 ? 5.182   -34.113 41.319  1.00 59.35  ? 117 LEU B O   1 
ATOM 5408  C CB  . LEU B 2 117 ? 2.437   -32.874 40.570  1.00 47.65  ? 117 LEU B CB  1 
ATOM 5409  C CG  . LEU B 2 117 ? 1.841   -32.530 41.934  1.00 48.98  ? 117 LEU B CG  1 
ATOM 5410  C CD1 . LEU B 2 117 ? 1.540   -31.051 41.998  1.00 53.38  ? 117 LEU B CD1 1 
ATOM 5411  C CD2 . LEU B 2 117 ? 0.593   -33.329 42.200  1.00 50.58  ? 117 LEU B CD2 1 
ATOM 5412  N N   . VAL B 2 118 ? 5.197   -32.113 42.355  1.00 41.18  ? 118 VAL B N   1 
ATOM 5413  C CA  . VAL B 2 118 ? 5.999   -32.571 43.473  1.00 40.89  ? 118 VAL B CA  1 
ATOM 5414  C C   . VAL B 2 118 ? 5.212   -32.288 44.747  1.00 44.51  ? 118 VAL B C   1 
ATOM 5415  O O   . VAL B 2 118 ? 4.824   -31.146 44.988  1.00 49.06  ? 118 VAL B O   1 
ATOM 5416  C CB  . VAL B 2 118 ? 7.372   -31.881 43.532  1.00 42.43  ? 118 VAL B CB  1 
ATOM 5417  C CG1 . VAL B 2 118 ? 8.131   -32.271 44.794  1.00 45.05  ? 118 VAL B CG1 1 
ATOM 5418  C CG2 . VAL B 2 118 ? 8.217   -32.140 42.294  1.00 41.07  ? 118 VAL B CG2 1 
ATOM 5419  N N   . THR B 2 119 ? 4.957   -33.330 45.550  1.00 43.69  ? 119 THR B N   1 
ATOM 5420  C CA  . THR B 2 119 ? 4.334   -33.144 46.852  1.00 43.20  ? 119 THR B CA  1 
ATOM 5421  C C   . THR B 2 119 ? 5.395   -33.527 47.867  1.00 45.25  ? 119 THR B C   1 
ATOM 5422  O O   . THR B 2 119 ? 6.171   -34.444 47.617  1.00 45.98  ? 119 THR B O   1 
ATOM 5423  C CB  . THR B 2 119 ? 3.053   -33.961 47.080  1.00 43.53  ? 119 THR B CB  1 
ATOM 5424  O OG1 . THR B 2 119 ? 2.045   -33.808 46.078  1.00 44.34  ? 119 THR B OG1 1 
ATOM 5425  C CG2 . THR B 2 119 ? 2.377   -33.568 48.382  1.00 42.80  ? 119 THR B CG2 1 
ATOM 5426  N N   . VAL B 2 120 ? 5.433   -32.792 48.979  1.00 47.55  ? 120 VAL B N   1 
ATOM 5427  C CA  . VAL B 2 120 ? 6.325   -33.119 50.070  1.00 52.14  ? 120 VAL B CA  1 
ATOM 5428  C C   . VAL B 2 120 ? 5.459   -33.165 51.325  1.00 54.58  ? 120 VAL B C   1 
ATOM 5429  O O   . VAL B 2 120 ? 4.909   -32.157 51.762  1.00 58.26  ? 120 VAL B O   1 
ATOM 5430  C CB  . VAL B 2 120 ? 7.510   -32.128 50.176  1.00 54.15  ? 120 VAL B CB  1 
ATOM 5431  C CG1 . VAL B 2 120 ? 8.426   -32.419 51.362  1.00 59.57  ? 120 VAL B CG1 1 
ATOM 5432  C CG2 . VAL B 2 120 ? 8.354   -32.100 48.910  1.00 50.94  ? 120 VAL B CG2 1 
ATOM 5433  N N   . SER B 2 121 ? 5.288   -34.368 51.858  1.00 53.60  ? 121 SER B N   1 
ATOM 5434  C CA  . SER B 2 121 ? 4.755   -34.516 53.197  1.00 62.43  ? 121 SER B CA  1 
ATOM 5435  C C   . SER B 2 121 ? 5.018   -35.947 53.637  1.00 69.31  ? 121 SER B C   1 
ATOM 5436  O O   . SER B 2 121 ? 5.262   -36.828 52.806  1.00 65.76  ? 121 SER B O   1 
ATOM 5437  C CB  . SER B 2 121 ? 3.272   -34.136 53.311  1.00 68.24  ? 121 SER B CB  1 
ATOM 5438  O OG  . SER B 2 121 ? 2.385   -35.090 52.735  1.00 61.98  ? 121 SER B OG  1 
ATOM 5439  N N   . SER B 2 122 ? 5.014   -36.148 54.958  1.00 74.89  ? 122 SER B N   1 
ATOM 5440  C CA  . SER B 2 122 ? 5.178   -37.479 55.512  1.00 77.08  ? 122 SER B CA  1 
ATOM 5441  C C   . SER B 2 122 ? 3.792   -38.140 55.579  1.00 83.49  ? 122 SER B C   1 
ATOM 5442  O O   . SER B 2 122 ? 2.839   -37.510 55.043  1.00 74.33  ? 122 SER B O   1 
ATOM 5443  C CB  . SER B 2 122 ? 5.939   -37.471 56.840  1.00 65.82  ? 122 SER B CB  1 
ATOM 5444  O OG  . SER B 2 122 ? 5.957   -36.185 57.442  1.00 53.18  ? 122 SER B OG  1 
ATOM 5445  O OXT . SER B 2 122 ? 3.719   -39.280 56.105  1.00 95.97  ? 122 SER B OXT 1 
ATOM 5446  N N   . HIS C 1 9   ? -5.584  39.224  44.224  1.00 111.80 ? 3   HIS C N   1 
ATOM 5447  C CA  . HIS C 1 9   ? -5.698  38.288  45.378  1.00 107.59 ? 3   HIS C CA  1 
ATOM 5448  C C   . HIS C 1 9   ? -5.075  38.947  46.607  1.00 102.91 ? 3   HIS C C   1 
ATOM 5449  O O   . HIS C 1 9   ? -3.883  39.257  46.617  1.00 101.25 ? 3   HIS C O   1 
ATOM 5450  C CB  . HIS C 1 9   ? -5.036  36.942  45.053  1.00 108.21 ? 3   HIS C CB  1 
ATOM 5451  C CG  . HIS C 1 9   ? -3.563  37.048  44.798  1.00 120.35 ? 3   HIS C CG  1 
ATOM 5452  N ND1 . HIS C 1 9   ? -3.013  37.094  43.533  1.00 126.19 ? 3   HIS C ND1 1 
ATOM 5453  C CD2 . HIS C 1 9   ? -2.525  37.131  45.649  1.00 125.51 ? 3   HIS C CD2 1 
ATOM 5454  C CE1 . HIS C 1 9   ? -1.694  37.202  43.628  1.00 126.04 ? 3   HIS C CE1 1 
ATOM 5455  N NE2 . HIS C 1 9   ? -1.376  37.229  44.904  1.00 127.69 ? 3   HIS C NE2 1 
ATOM 5456  N N   . LYS C 1 10  ? -5.894  39.172  47.638  1.00 96.31  ? 4   LYS C N   1 
ATOM 5457  C CA  . LYS C 1 10  ? -5.383  39.597  48.930  1.00 99.76  ? 4   LYS C CA  1 
ATOM 5458  C C   . LYS C 1 10  ? -5.073  38.336  49.735  1.00 107.38 ? 4   LYS C C   1 
ATOM 5459  O O   . LYS C 1 10  ? -3.955  38.150  50.209  1.00 119.86 ? 4   LYS C O   1 
ATOM 5460  C CB  . LYS C 1 10  ? -6.345  40.515  49.695  1.00 98.83  ? 4   LYS C CB  1 
ATOM 5461  C CG  . LYS C 1 10  ? -7.302  41.359  48.854  1.00 105.82 ? 4   LYS C CG  1 
ATOM 5462  C CD  . LYS C 1 10  ? -8.660  40.689  48.633  1.00 108.83 ? 4   LYS C CD  1 
ATOM 5463  C CE  . LYS C 1 10  ? -9.613  41.433  47.745  1.00 100.43 ? 4   LYS C CE  1 
ATOM 5464  N NZ  . LYS C 1 10  ? -9.968  42.734  48.316  1.00 96.54  ? 4   LYS C NZ  1 
ATOM 5465  N N   . SER C 1 11  ? -6.070  37.455  49.847  1.00 98.61  ? 5   SER C N   1 
ATOM 5466  C CA  . SER C 1 11  ? -5.915  36.195  50.553  1.00 94.06  ? 5   SER C CA  1 
ATOM 5467  C C   . SER C 1 11  ? -5.081  35.222  49.719  1.00 95.85  ? 5   SER C C   1 
ATOM 5468  O O   . SER C 1 11  ? -5.554  34.708  48.709  1.00 112.92 ? 5   SER C O   1 
ATOM 5469  C CB  . SER C 1 11  ? -7.277  35.625  50.885  1.00 91.60  ? 5   SER C CB  1 
ATOM 5470  O OG  . SER C 1 11  ? -7.198  34.330  51.463  1.00 87.35  ? 5   SER C OG  1 
ATOM 5471  N N   . GLU C 1 12  ? -3.839  34.969  50.152  1.00 87.74  ? 6   GLU C N   1 
ATOM 5472  C CA  . GLU C 1 12  ? -3.004  33.925  49.568  1.00 85.67  ? 6   GLU C CA  1 
ATOM 5473  C C   . GLU C 1 12  ? -3.617  32.544  49.810  1.00 72.72  ? 6   GLU C C   1 
ATOM 5474  O O   . GLU C 1 12  ? -3.710  31.738  48.892  1.00 67.97  ? 6   GLU C O   1 
ATOM 5475  C CB  . GLU C 1 12  ? -1.573  33.979  50.112  1.00 90.84  ? 6   GLU C CB  1 
ATOM 5476  C CG  . GLU C 1 12  ? -0.645  34.888  49.309  1.00 89.87  ? 6   GLU C CG  1 
ATOM 5477  C CD  . GLU C 1 12  ? -0.121  34.228  48.044  1.00 92.67  ? 6   GLU C CD  1 
ATOM 5478  O OE1 . GLU C 1 12  ? 0.814   33.405  48.156  1.00 93.12  ? 6   GLU C OE1 1 
ATOM 5479  O OE2 . GLU C 1 12  ? -0.660  34.503  46.952  1.00 93.25  ? 6   GLU C OE2 1 
ATOM 5480  N N   . VAL C 1 13  ? -4.027  32.272  51.049  1.00 68.49  ? 7   VAL C N   1 
ATOM 5481  C CA  . VAL C 1 13  ? -4.697  31.022  51.369  1.00 76.17  ? 7   VAL C CA  1 
ATOM 5482  C C   . VAL C 1 13  ? -5.760  30.708  50.312  1.00 76.79  ? 7   VAL C C   1 
ATOM 5483  O O   . VAL C 1 13  ? -5.831  29.578  49.828  1.00 91.77  ? 7   VAL C O   1 
ATOM 5484  C CB  . VAL C 1 13  ? -5.302  30.972  52.789  1.00 81.75  ? 7   VAL C CB  1 
ATOM 5485  C CG1 . VAL C 1 13  ? -4.343  30.355  53.796  1.00 80.83  ? 7   VAL C CG1 1 
ATOM 5486  C CG2 . VAL C 1 13  ? -5.786  32.330  53.279  1.00 88.42  ? 7   VAL C CG2 1 
ATOM 5487  N N   . ALA C 1 14  ? -6.591  31.687  49.947  1.00 62.56  ? 8   ALA C N   1 
ATOM 5488  C CA  . ALA C 1 14  ? -7.661  31.402  49.009  1.00 66.70  ? 8   ALA C CA  1 
ATOM 5489  C C   . ALA C 1 14  ? -7.121  31.264  47.581  1.00 68.83  ? 8   ALA C C   1 
ATOM 5490  O O   . ALA C 1 14  ? -7.687  30.508  46.784  1.00 69.01  ? 8   ALA C O   1 
ATOM 5491  C CB  . ALA C 1 14  ? -8.732  32.453  49.118  1.00 70.89  ? 8   ALA C CB  1 
ATOM 5492  N N   . HIS C 1 15  ? -6.026  31.974  47.255  1.00 61.42  ? 9   HIS C N   1 
ATOM 5493  C CA  . HIS C 1 15  ? -5.384  31.827  45.955  1.00 56.19  ? 9   HIS C CA  1 
ATOM 5494  C C   . HIS C 1 15  ? -4.962  30.377  45.757  1.00 53.04  ? 9   HIS C C   1 
ATOM 5495  O O   . HIS C 1 15  ? -5.190  29.807  44.700  1.00 58.88  ? 9   HIS C O   1 
ATOM 5496  C CB  . HIS C 1 15  ? -4.205  32.788  45.796  1.00 57.29  ? 9   HIS C CB  1 
ATOM 5497  C CG  . HIS C 1 15  ? -3.572  32.799  44.440  1.00 67.79  ? 9   HIS C CG  1 
ATOM 5498  N ND1 . HIS C 1 15  ? -4.068  33.495  43.354  1.00 79.23  ? 9   HIS C ND1 1 
ATOM 5499  C CD2 . HIS C 1 15  ? -2.434  32.227  44.016  1.00 72.85  ? 9   HIS C CD2 1 
ATOM 5500  C CE1 . HIS C 1 15  ? -3.264  33.321  42.307  1.00 79.28  ? 9   HIS C CE1 1 
ATOM 5501  N NE2 . HIS C 1 15  ? -2.263  32.553  42.689  1.00 76.60  ? 9   HIS C NE2 1 
ATOM 5502  N N   . ARG C 1 16  ? -4.412  29.761  46.802  1.00 54.98  ? 10  ARG C N   1 
ATOM 5503  C CA  . ARG C 1 16  ? -3.925  28.390  46.722  1.00 60.97  ? 10  ARG C CA  1 
ATOM 5504  C C   . ARG C 1 16  ? -5.074  27.390  46.802  1.00 61.41  ? 10  ARG C C   1 
ATOM 5505  O O   . ARG C 1 16  ? -5.120  26.435  46.023  1.00 50.37  ? 10  ARG C O   1 
ATOM 5506  C CB  . ARG C 1 16  ? -2.917  28.130  47.848  1.00 64.38  ? 10  ARG C CB  1 
ATOM 5507  C CG  . ARG C 1 16  ? -1.763  29.122  47.840  1.00 64.10  ? 10  ARG C CG  1 
ATOM 5508  C CD  . ARG C 1 16  ? -1.264  29.361  46.430  1.00 59.67  ? 10  ARG C CD  1 
ATOM 5509  N NE  . ARG C 1 16  ? -0.156  30.313  46.374  1.00 60.08  ? 10  ARG C NE  1 
ATOM 5510  C CZ  . ARG C 1 16  ? 0.430   30.684  45.246  1.00 67.84  ? 10  ARG C CZ  1 
ATOM 5511  N NH1 . ARG C 1 16  ? -0.020  30.250  44.078  1.00 67.24  ? 10  ARG C NH1 1 
ATOM 5512  N NH2 . ARG C 1 16  ? 1.476   31.489  45.288  1.00 70.99  ? 10  ARG C NH2 1 
ATOM 5513  N N   . PHE C 1 17  ? -5.982  27.611  47.763  1.00 63.88  ? 11  PHE C N   1 
ATOM 5514  C CA  . PHE C 1 17  ? -7.129  26.737  47.931  1.00 64.24  ? 11  PHE C CA  1 
ATOM 5515  C C   . PHE C 1 17  ? -7.870  26.605  46.600  1.00 60.52  ? 11  PHE C C   1 
ATOM 5516  O O   . PHE C 1 17  ? -8.203  25.491  46.206  1.00 54.20  ? 11  PHE C O   1 
ATOM 5517  C CB  . PHE C 1 17  ? -8.068  27.215  49.041  1.00 62.40  ? 11  PHE C CB  1 
ATOM 5518  C CG  . PHE C 1 17  ? -9.043  26.118  49.438  1.00 64.18  ? 11  PHE C CG  1 
ATOM 5519  C CD1 . PHE C 1 17  ? -8.682  25.154  50.372  1.00 64.92  ? 11  PHE C CD1 1 
ATOM 5520  C CD2 . PHE C 1 17  ? -10.294 26.025  48.839  1.00 66.68  ? 11  PHE C CD2 1 
ATOM 5521  C CE1 . PHE C 1 17  ? -9.565  24.144  50.718  1.00 69.74  ? 11  PHE C CE1 1 
ATOM 5522  C CE2 . PHE C 1 17  ? -11.175 25.018  49.193  1.00 69.98  ? 11  PHE C CE2 1 
ATOM 5523  C CZ  . PHE C 1 17  ? -10.812 24.082  50.136  1.00 69.92  ? 11  PHE C CZ  1 
ATOM 5524  N N   . LYS C 1 18  ? -8.104  27.745  45.924  1.00 59.80  ? 12  LYS C N   1 
ATOM 5525  C CA  . LYS C 1 18  ? -8.839  27.793  44.670  1.00 56.48  ? 12  LYS C CA  1 
ATOM 5526  C C   . LYS C 1 18  ? -8.088  27.035  43.583  1.00 59.63  ? 12  LYS C C   1 
ATOM 5527  O O   . LYS C 1 18  ? -8.717  26.289  42.834  1.00 54.46  ? 12  LYS C O   1 
ATOM 5528  C CB  . LYS C 1 18  ? -9.076  29.243  44.243  1.00 59.67  ? 12  LYS C CB  1 
ATOM 5529  C CG  . LYS C 1 18  ? -10.180 29.912  45.033  1.00 69.62  ? 12  LYS C CG  1 
ATOM 5530  C CD  . LYS C 1 18  ? -10.368 31.409  44.795  1.00 76.79  ? 12  LYS C CD  1 
ATOM 5531  C CE  . LYS C 1 18  ? -11.365 31.980  45.771  1.00 79.58  ? 12  LYS C CE  1 
ATOM 5532  N NZ  . LYS C 1 18  ? -11.315 33.435  45.934  1.00 78.37  ? 12  LYS C NZ  1 
ATOM 5533  N N   . ASP C 1 19  ? -6.755  27.229  43.529  1.00 63.35  ? 13  ASP C N   1 
ATOM 5534  C CA  . ASP C 1 19  ? -5.903  26.691  42.474  1.00 62.15  ? 13  ASP C CA  1 
ATOM 5535  C C   . ASP C 1 19  ? -5.570  25.213  42.684  1.00 62.48  ? 13  ASP C C   1 
ATOM 5536  O O   . ASP C 1 19  ? -5.437  24.490  41.705  1.00 65.08  ? 13  ASP C O   1 
ATOM 5537  C CB  . ASP C 1 19  ? -4.602  27.470  42.342  1.00 62.16  ? 13  ASP C CB  1 
ATOM 5538  C CG  . ASP C 1 19  ? -4.669  28.722  41.479  1.00 68.51  ? 13  ASP C CG  1 
ATOM 5539  O OD1 . ASP C 1 19  ? -5.736  28.978  40.882  1.00 73.36  ? 13  ASP C OD1 1 
ATOM 5540  O OD2 . ASP C 1 19  ? -3.649  29.436  41.400  1.00 75.51  ? 13  ASP C OD2 1 
ATOM 5541  N N   . LEU C 1 20  ? -5.383  24.779  43.940  1.00 61.17  ? 14  LEU C N   1 
ATOM 5542  C CA  . LEU C 1 20  ? -4.903  23.434  44.223  1.00 54.96  ? 14  LEU C CA  1 
ATOM 5543  C C   . LEU C 1 20  ? -6.079  22.503  44.483  1.00 59.04  ? 14  LEU C C   1 
ATOM 5544  O O   . LEU C 1 20  ? -5.917  21.288  44.417  1.00 70.99  ? 14  LEU C O   1 
ATOM 5545  C CB  . LEU C 1 20  ? -3.954  23.423  45.420  1.00 52.82  ? 14  LEU C CB  1 
ATOM 5546  C CG  . LEU C 1 20  ? -2.635  24.186  45.273  1.00 51.17  ? 14  LEU C CG  1 
ATOM 5547  C CD1 . LEU C 1 20  ? -1.954  24.311  46.625  1.00 49.65  ? 14  LEU C CD1 1 
ATOM 5548  C CD2 . LEU C 1 20  ? -1.718  23.519  44.260  1.00 50.04  ? 14  LEU C CD2 1 
ATOM 5549  N N   . GLY C 1 21  ? -7.242  23.063  44.830  1.00 57.33  ? 15  GLY C N   1 
ATOM 5550  C CA  . GLY C 1 21  ? -8.369  22.247  45.252  1.00 62.31  ? 15  GLY C CA  1 
ATOM 5551  C C   . GLY C 1 21  ? -8.167  21.692  46.663  1.00 62.29  ? 15  GLY C C   1 
ATOM 5552  O O   . GLY C 1 21  ? -7.043  21.616  47.155  1.00 50.68  ? 15  GLY C O   1 
ATOM 5553  N N   . GLU C 1 22  ? -9.274  21.285  47.297  1.00 69.04  ? 16  GLU C N   1 
ATOM 5554  C CA  . GLU C 1 22  ? -9.278  20.892  48.698  1.00 71.16  ? 16  GLU C CA  1 
ATOM 5555  C C   . GLU C 1 22  ? -8.343  19.708  48.949  1.00 65.95  ? 16  GLU C C   1 
ATOM 5556  O O   . GLU C 1 22  ? -7.584  19.723  49.916  1.00 55.82  ? 16  GLU C O   1 
ATOM 5557  C CB  . GLU C 1 22  ? -10.686 20.519  49.168  1.00 77.27  ? 16  GLU C CB  1 
ATOM 5558  C CG  . GLU C 1 22  ? -10.782 20.463  50.689  1.00 80.57  ? 16  GLU C CG  1 
ATOM 5559  C CD  . GLU C 1 22  ? -12.145 20.105  51.230  1.00 83.34  ? 16  GLU C CD  1 
ATOM 5560  O OE1 . GLU C 1 22  ? -13.134 20.604  50.663  1.00 84.52  ? 16  GLU C OE1 1 
ATOM 5561  O OE2 . GLU C 1 22  ? -12.208 19.367  52.236  1.00 97.53  ? 16  GLU C OE2 1 
ATOM 5562  N N   . GLU C 1 23  ? -8.421  18.678  48.091  1.00 63.18  ? 17  GLU C N   1 
ATOM 5563  C CA  . GLU C 1 23  ? -7.666  17.456  48.302  1.00 66.68  ? 17  GLU C CA  1 
ATOM 5564  C C   . GLU C 1 23  ? -6.168  17.752  48.435  1.00 63.10  ? 17  GLU C C   1 
ATOM 5565  O O   . GLU C 1 23  ? -5.554  17.443  49.463  1.00 56.65  ? 17  GLU C O   1 
ATOM 5566  C CB  . GLU C 1 23  ? -7.929  16.441  47.190  1.00 71.83  ? 17  GLU C CB  1 
ATOM 5567  C CG  . GLU C 1 23  ? -7.311  15.087  47.528  1.00 80.74  ? 17  GLU C CG  1 
ATOM 5568  C CD  . GLU C 1 23  ? -7.697  13.914  46.658  1.00 81.86  ? 17  GLU C CD  1 
ATOM 5569  O OE1 . GLU C 1 23  ? -8.845  13.906  46.171  1.00 87.07  ? 17  GLU C OE1 1 
ATOM 5570  O OE2 . GLU C 1 23  ? -6.861  12.988  46.537  1.00 83.89  ? 17  GLU C OE2 1 
ATOM 5571  N N   . ASN C 1 24  ? -5.589  18.342  47.381  1.00 61.09  ? 18  ASN C N   1 
ATOM 5572  C CA  . ASN C 1 24  ? -4.153  18.587  47.319  1.00 58.56  ? 18  ASN C CA  1 
ATOM 5573  C C   . ASN C 1 24  ? -3.724  19.568  48.417  1.00 52.03  ? 18  ASN C C   1 
ATOM 5574  O O   . ASN C 1 24  ? -2.664  19.417  49.015  1.00 46.39  ? 18  ASN C O   1 
ATOM 5575  C CB  . ASN C 1 24  ? -3.710  19.057  45.931  1.00 57.05  ? 18  ASN C CB  1 
ATOM 5576  C CG  . ASN C 1 24  ? -3.840  18.016  44.836  1.00 53.83  ? 18  ASN C CG  1 
ATOM 5577  O OD1 . ASN C 1 24  ? -4.231  18.357  43.715  1.00 54.76  ? 18  ASN C OD1 1 
ATOM 5578  N ND2 . ASN C 1 24  ? -3.454  16.771  45.085  1.00 49.99  ? 18  ASN C ND2 1 
ATOM 5579  N N   . PHE C 1 25  ? -4.554  20.577  48.682  1.00 55.07  ? 19  PHE C N   1 
ATOM 5580  C CA  . PHE C 1 25  ? -4.289  21.550  49.736  1.00 60.93  ? 19  PHE C CA  1 
ATOM 5581  C C   . PHE C 1 25  ? -4.077  20.838  51.078  1.00 53.58  ? 19  PHE C C   1 
ATOM 5582  O O   . PHE C 1 25  ? -3.065  21.010  51.750  1.00 42.94  ? 19  PHE C O   1 
ATOM 5583  C CB  . PHE C 1 25  ? -5.462  22.542  49.769  1.00 66.70  ? 19  PHE C CB  1 
ATOM 5584  C CG  . PHE C 1 25  ? -5.309  23.697  50.746  1.00 63.82  ? 19  PHE C CG  1 
ATOM 5585  C CD1 . PHE C 1 25  ? -5.580  23.530  52.098  1.00 64.73  ? 19  PHE C CD1 1 
ATOM 5586  C CD2 . PHE C 1 25  ? -4.879  24.941  50.310  1.00 67.93  ? 19  PHE C CD2 1 
ATOM 5587  C CE1 . PHE C 1 25  ? -5.415  24.572  52.993  1.00 64.22  ? 19  PHE C CE1 1 
ATOM 5588  C CE2 . PHE C 1 25  ? -4.722  25.984  51.212  1.00 72.02  ? 19  PHE C CE2 1 
ATOM 5589  C CZ  . PHE C 1 25  ? -4.982  25.795  52.552  1.00 66.16  ? 19  PHE C CZ  1 
ATOM 5590  N N   . LYS C 1 26  ? -5.057  20.033  51.484  1.00 56.05  ? 20  LYS C N   1 
ATOM 5591  C CA  . LYS C 1 26  ? -4.966  19.354  52.764  1.00 56.96  ? 20  LYS C CA  1 
ATOM 5592  C C   . LYS C 1 26  ? -3.680  18.532  52.781  1.00 54.77  ? 20  LYS C C   1 
ATOM 5593  O O   . LYS C 1 26  ? -2.987  18.479  53.793  1.00 57.02  ? 20  LYS C O   1 
ATOM 5594  C CB  . LYS C 1 26  ? -6.208  18.496  53.031  1.00 55.16  ? 20  LYS C CB  1 
ATOM 5595  C CG  . LYS C 1 26  ? -7.496  19.267  53.212  1.00 57.32  ? 20  LYS C CG  1 
ATOM 5596  C CD  . LYS C 1 26  ? -8.725  18.385  53.381  1.00 63.60  ? 20  LYS C CD  1 
ATOM 5597  C CE  . LYS C 1 26  ? -8.795  17.761  54.743  1.00 69.31  ? 20  LYS C CE  1 
ATOM 5598  N NZ  . LYS C 1 26  ? -9.882  16.784  54.787  1.00 72.63  ? 20  LYS C NZ  1 
ATOM 5599  N N   . ALA C 1 27  ? -3.375  17.888  51.650  1.00 47.95  ? 21  ALA C N   1 
ATOM 5600  C CA  . ALA C 1 27  ? -2.233  17.001  51.587  1.00 46.00  ? 21  ALA C CA  1 
ATOM 5601  C C   . ALA C 1 27  ? -0.949  17.814  51.736  1.00 45.01  ? 21  ALA C C   1 
ATOM 5602  O O   . ALA C 1 27  ? 0.017   17.390  52.376  1.00 40.88  ? 21  ALA C O   1 
ATOM 5603  C CB  . ALA C 1 27  ? -2.270  16.224  50.302  1.00 45.53  ? 21  ALA C CB  1 
ATOM 5604  N N   . LEU C 1 28  ? -0.942  19.008  51.154  1.00 44.82  ? 22  LEU C N   1 
ATOM 5605  C CA  . LEU C 1 28  ? 0.279   19.789  51.169  1.00 50.09  ? 22  LEU C CA  1 
ATOM 5606  C C   . LEU C 1 28  ? 0.508   20.316  52.579  1.00 58.27  ? 22  LEU C C   1 
ATOM 5607  O O   . LEU C 1 28  ? 1.590   20.134  53.128  1.00 67.52  ? 22  LEU C O   1 
ATOM 5608  C CB  . LEU C 1 28  ? 0.259   20.885  50.107  1.00 50.00  ? 22  LEU C CB  1 
ATOM 5609  C CG  . LEU C 1 28  ? 0.570   20.400  48.683  1.00 48.89  ? 22  LEU C CG  1 
ATOM 5610  C CD1 . LEU C 1 28  ? -0.086  21.283  47.623  1.00 51.88  ? 22  LEU C CD1 1 
ATOM 5611  C CD2 . LEU C 1 28  ? 2.076   20.299  48.448  1.00 42.52  ? 22  LEU C CD2 1 
ATOM 5612  N N   . VAL C 1 29  ? -0.524  20.918  53.182  1.00 63.67  ? 23  VAL C N   1 
ATOM 5613  C CA  . VAL C 1 29  ? -0.388  21.479  54.520  1.00 58.68  ? 23  VAL C CA  1 
ATOM 5614  C C   . VAL C 1 29  ? 0.082   20.374  55.456  1.00 55.65  ? 23  VAL C C   1 
ATOM 5615  O O   . VAL C 1 29  ? 0.940   20.621  56.296  1.00 56.31  ? 23  VAL C O   1 
ATOM 5616  C CB  . VAL C 1 29  ? -1.657  22.160  55.064  1.00 55.47  ? 23  VAL C CB  1 
ATOM 5617  C CG1 . VAL C 1 29  ? -2.064  23.351  54.208  1.00 60.09  ? 23  VAL C CG1 1 
ATOM 5618  C CG2 . VAL C 1 29  ? -2.827  21.203  55.128  1.00 58.43  ? 23  VAL C CG2 1 
ATOM 5619  N N   . LEU C 1 30  ? -0.449  19.156  55.275  1.00 53.50  ? 24  LEU C N   1 
ATOM 5620  C CA  . LEU C 1 30  ? -0.069  18.046  56.132  1.00 56.14  ? 24  LEU C CA  1 
ATOM 5621  C C   . LEU C 1 30  ? 1.442   17.877  56.026  1.00 55.57  ? 24  LEU C C   1 
ATOM 5622  O O   . LEU C 1 30  ? 2.148   17.834  57.039  1.00 58.38  ? 24  LEU C O   1 
ATOM 5623  C CB  . LEU C 1 30  ? -0.798  16.738  55.815  1.00 57.13  ? 24  LEU C CB  1 
ATOM 5624  C CG  . LEU C 1 30  ? -0.286  15.489  56.551  1.00 57.40  ? 24  LEU C CG  1 
ATOM 5625  C CD1 . LEU C 1 30  ? -0.256  15.704  58.064  1.00 56.82  ? 24  LEU C CD1 1 
ATOM 5626  C CD2 . LEU C 1 30  ? -1.091  14.243  56.225  1.00 56.09  ? 24  LEU C CD2 1 
ATOM 5627  N N   . ILE C 1 31  ? 1.932   17.804  54.788  1.00 50.35  ? 25  ILE C N   1 
ATOM 5628  C CA  . ILE C 1 31  ? 3.357   17.621  54.580  1.00 50.57  ? 25  ILE C CA  1 
ATOM 5629  C C   . ILE C 1 31  ? 4.103   18.721  55.342  1.00 59.51  ? 25  ILE C C   1 
ATOM 5630  O O   . ILE C 1 31  ? 4.978   18.422  56.152  1.00 62.62  ? 25  ILE C O   1 
ATOM 5631  C CB  . ILE C 1 31  ? 3.704   17.572  53.078  1.00 43.00  ? 25  ILE C CB  1 
ATOM 5632  C CG1 . ILE C 1 31  ? 3.095   16.344  52.416  1.00 41.64  ? 25  ILE C CG1 1 
ATOM 5633  C CG2 . ILE C 1 31  ? 5.217   17.617  52.871  1.00 41.65  ? 25  ILE C CG2 1 
ATOM 5634  C CD1 . ILE C 1 31  ? 3.002   16.398  50.906  1.00 39.92  ? 25  ILE C CD1 1 
ATOM 5635  N N   . ALA C 1 32  ? 3.704   19.985  55.123  1.00 63.71  ? 26  ALA C N   1 
ATOM 5636  C CA  . ALA C 1 32  ? 4.407   21.143  55.656  1.00 57.44  ? 26  ALA C CA  1 
ATOM 5637  C C   . ALA C 1 32  ? 4.635   20.992  57.153  1.00 56.78  ? 26  ALA C C   1 
ATOM 5638  O O   . ALA C 1 32  ? 5.770   21.122  57.613  1.00 55.47  ? 26  ALA C O   1 
ATOM 5639  C CB  . ALA C 1 32  ? 3.636   22.397  55.349  1.00 57.54  ? 26  ALA C CB  1 
ATOM 5640  N N   . PHE C 1 33  ? 3.543   20.707  57.879  1.00 54.46  ? 27  PHE C N   1 
ATOM 5641  C CA  . PHE C 1 33  ? 3.589   20.503  59.317  1.00 53.77  ? 27  PHE C CA  1 
ATOM 5642  C C   . PHE C 1 33  ? 4.459   19.287  59.610  1.00 47.97  ? 27  PHE C C   1 
ATOM 5643  O O   . PHE C 1 33  ? 5.328   19.341  60.478  1.00 51.93  ? 27  PHE C O   1 
ATOM 5644  C CB  . PHE C 1 33  ? 2.198   20.329  59.941  1.00 57.19  ? 27  PHE C CB  1 
ATOM 5645  C CG  . PHE C 1 33  ? 1.276   21.537  59.868  1.00 61.44  ? 27  PHE C CG  1 
ATOM 5646  C CD1 . PHE C 1 33  ? 1.777   22.807  59.605  1.00 66.17  ? 27  PHE C CD1 1 
ATOM 5647  C CD2 . PHE C 1 33  ? -0.093  21.392  60.071  1.00 68.51  ? 27  PHE C CD2 1 
ATOM 5648  C CE1 . PHE C 1 33  ? 0.926   23.896  59.526  1.00 76.94  ? 27  PHE C CE1 1 
ATOM 5649  C CE2 . PHE C 1 33  ? -0.939  22.487  60.003  1.00 76.07  ? 27  PHE C CE2 1 
ATOM 5650  C CZ  . PHE C 1 33  ? -0.429  23.735  59.726  1.00 81.17  ? 27  PHE C CZ  1 
ATOM 5651  N N   . ALA C 1 34  ? 4.239   18.203  58.863  1.00 42.63  ? 28  ALA C N   1 
ATOM 5652  C CA  . ALA C 1 34  ? 4.948   16.961  59.122  1.00 47.16  ? 28  ALA C CA  1 
ATOM 5653  C C   . ALA C 1 34  ? 6.465   17.180  59.084  1.00 49.03  ? 28  ALA C C   1 
ATOM 5654  O O   . ALA C 1 34  ? 7.229   16.599  59.856  1.00 46.56  ? 28  ALA C O   1 
ATOM 5655  C CB  . ALA C 1 34  ? 4.499   15.908  58.128  1.00 47.59  ? 28  ALA C CB  1 
ATOM 5656  N N   . GLN C 1 35  ? 6.903   18.044  58.172  1.00 51.54  ? 29  GLN C N   1 
ATOM 5657  C CA  . GLN C 1 35  ? 8.316   18.240  57.937  1.00 49.06  ? 29  GLN C CA  1 
ATOM 5658  C C   . GLN C 1 35  ? 8.882   19.210  58.959  1.00 52.82  ? 29  GLN C C   1 
ATOM 5659  O O   . GLN C 1 35  ? 10.092  19.202  59.167  1.00 57.39  ? 29  GLN C O   1 
ATOM 5660  C CB  . GLN C 1 35  ? 8.517   18.742  56.513  1.00 49.96  ? 29  GLN C CB  1 
ATOM 5661  C CG  . GLN C 1 35  ? 8.102   17.722  55.462  1.00 49.92  ? 29  GLN C CG  1 
ATOM 5662  C CD  . GLN C 1 35  ? 8.455   18.155  54.064  1.00 48.23  ? 29  GLN C CD  1 
ATOM 5663  O OE1 . GLN C 1 35  ? 8.014   19.201  53.581  1.00 46.09  ? 29  GLN C OE1 1 
ATOM 5664  N NE2 . GLN C 1 35  ? 9.270   17.349  53.408  1.00 51.42  ? 29  GLN C NE2 1 
ATOM 5665  N N   . TYR C 1 36  ? 8.029   20.037  59.585  1.00 56.66  ? 30  TYR C N   1 
ATOM 5666  C CA  . TYR C 1 36  ? 8.511   20.948  60.621  1.00 66.46  ? 30  TYR C CA  1 
ATOM 5667  C C   . TYR C 1 36  ? 8.452   20.235  61.977  1.00 74.54  ? 30  TYR C C   1 
ATOM 5668  O O   . TYR C 1 36  ? 9.458   20.137  62.688  1.00 74.47  ? 30  TYR C O   1 
ATOM 5669  C CB  . TYR C 1 36  ? 7.776   22.294  60.642  1.00 63.35  ? 30  TYR C CB  1 
ATOM 5670  C CG  . TYR C 1 36  ? 8.135   23.315  59.561  1.00 63.35  ? 30  TYR C CG  1 
ATOM 5671  C CD1 . TYR C 1 36  ? 8.537   22.940  58.279  1.00 66.18  ? 30  TYR C CD1 1 
ATOM 5672  C CD2 . TYR C 1 36  ? 8.013   24.676  59.809  1.00 62.65  ? 30  TYR C CD2 1 
ATOM 5673  C CE1 . TYR C 1 36  ? 8.812   23.881  57.293  1.00 63.75  ? 30  TYR C CE1 1 
ATOM 5674  C CE2 . TYR C 1 36  ? 8.286   25.627  58.835  1.00 63.86  ? 30  TYR C CE2 1 
ATOM 5675  C CZ  . TYR C 1 36  ? 8.693   25.232  57.570  1.00 61.60  ? 30  TYR C CZ  1 
ATOM 5676  O OH  . TYR C 1 36  ? 8.964   26.182  56.616  1.00 53.48  ? 30  TYR C OH  1 
ATOM 5677  N N   . LEU C 1 37  ? 7.267   19.721  62.326  1.00 73.87  ? 31  LEU C N   1 
ATOM 5678  C CA  . LEU C 1 37  ? 7.109   18.963  63.554  1.00 72.26  ? 31  LEU C CA  1 
ATOM 5679  C C   . LEU C 1 37  ? 7.221   17.489  63.212  1.00 71.24  ? 31  LEU C C   1 
ATOM 5680  O O   . LEU C 1 37  ? 6.231   16.872  62.829  1.00 67.14  ? 31  LEU C O   1 
ATOM 5681  C CB  . LEU C 1 37  ? 5.779   19.262  64.235  1.00 71.25  ? 31  LEU C CB  1 
ATOM 5682  C CG  . LEU C 1 37  ? 5.511   20.738  64.526  1.00 71.73  ? 31  LEU C CG  1 
ATOM 5683  C CD1 . LEU C 1 37  ? 4.096   20.902  65.025  1.00 72.25  ? 31  LEU C CD1 1 
ATOM 5684  C CD2 . LEU C 1 37  ? 6.521   21.277  65.521  1.00 73.11  ? 31  LEU C CD2 1 
ATOM 5685  N N   . GLN C 1 38  ? 8.438   16.958  63.383  1.00 75.87  ? 32  GLN C N   1 
ATOM 5686  C CA  . GLN C 1 38  ? 8.752   15.583  63.034  1.00 74.45  ? 32  GLN C CA  1 
ATOM 5687  C C   . GLN C 1 38  ? 8.117   14.668  64.082  1.00 78.60  ? 32  GLN C C   1 
ATOM 5688  O O   . GLN C 1 38  ? 7.127   13.990  63.807  1.00 77.53  ? 32  GLN C O   1 
ATOM 5689  C CB  . GLN C 1 38  ? 10.263  15.347  62.983  1.00 66.87  ? 32  GLN C CB  1 
ATOM 5690  C CG  . GLN C 1 38  ? 11.097  16.526  62.499  1.00 59.69  ? 32  GLN C CG  1 
ATOM 5691  C CD  . GLN C 1 38  ? 11.439  16.416  61.040  1.00 52.05  ? 32  GLN C CD  1 
ATOM 5692  O OE1 . GLN C 1 38  ? 10.547  16.508  60.199  1.00 54.02  ? 32  GLN C OE1 1 
ATOM 5693  N NE2 . GLN C 1 38  ? 12.714  16.200  60.745  1.00 49.65  ? 32  GLN C NE2 1 
ATOM 5694  N N   . GLN C 1 39  ? 8.686   14.692  65.296  1.00 80.08  ? 33  GLN C N   1 
ATOM 5695  C CA  . GLN C 1 39  ? 8.234   13.847  66.388  1.00 82.24  ? 33  GLN C CA  1 
ATOM 5696  C C   . GLN C 1 39  ? 6.999   14.504  66.978  1.00 70.50  ? 33  GLN C C   1 
ATOM 5697  O O   . GLN C 1 39  ? 7.091   15.425  67.775  1.00 85.55  ? 33  GLN C O   1 
ATOM 5698  C CB  . GLN C 1 39  ? 9.262   13.710  67.507  1.00 85.35  ? 33  GLN C CB  1 
ATOM 5699  C CG  . GLN C 1 39  ? 10.660  13.344  67.033  1.00 87.54  ? 33  GLN C CG  1 
ATOM 5700  C CD  . GLN C 1 39  ? 11.692  13.789  68.036  1.00 94.14  ? 33  GLN C CD  1 
ATOM 5701  O OE1 . GLN C 1 39  ? 11.671  14.936  68.498  1.00 95.76  ? 33  GLN C OE1 1 
ATOM 5702  N NE2 . GLN C 1 39  ? 12.567  12.870  68.415  1.00 101.81 ? 33  GLN C NE2 1 
ATOM 5703  N N   . CYS C 1 40  ? 5.845   14.082  66.500  1.00 60.15  ? 34  CYS C N   1 
ATOM 5704  C CA  . CYS C 1 40  ? 4.607   14.737  66.850  1.00 59.82  ? 34  CYS C CA  1 
ATOM 5705  C C   . CYS C 1 40  ? 3.532   13.840  66.261  1.00 54.48  ? 34  CYS C C   1 
ATOM 5706  O O   . CYS C 1 40  ? 3.620   13.430  65.110  1.00 58.67  ? 34  CYS C O   1 
ATOM 5707  C CB  . CYS C 1 40  ? 4.575   16.187  66.366  1.00 69.19  ? 34  CYS C CB  1 
ATOM 5708  S SG  . CYS C 1 40  ? 4.172   17.393  67.666  1.00 78.14  ? 34  CYS C SG  1 
ATOM 5709  N N   . PRO C 1 41  ? 2.541   13.425  67.057  1.00 50.50  ? 35  PRO C N   1 
ATOM 5710  C CA  . PRO C 1 41  ? 1.670   12.326  66.666  1.00 51.77  ? 35  PRO C CA  1 
ATOM 5711  C C   . PRO C 1 41  ? 0.776   12.706  65.499  1.00 50.80  ? 35  PRO C C   1 
ATOM 5712  O O   . PRO C 1 41  ? 0.361   13.855  65.407  1.00 50.05  ? 35  PRO C O   1 
ATOM 5713  C CB  . PRO C 1 41  ? 0.857   12.068  67.925  1.00 60.60  ? 35  PRO C CB  1 
ATOM 5714  C CG  . PRO C 1 41  ? 1.631   12.752  69.035  1.00 60.53  ? 35  PRO C CG  1 
ATOM 5715  C CD  . PRO C 1 41  ? 2.227   13.972  68.379  1.00 57.40  ? 35  PRO C CD  1 
ATOM 5716  N N   . PHE C 1 42  ? 0.477   11.711  64.655  1.00 53.78  ? 36  PHE C N   1 
ATOM 5717  C CA  . PHE C 1 42  ? -0.389  11.863  63.496  1.00 59.82  ? 36  PHE C CA  1 
ATOM 5718  C C   . PHE C 1 42  ? -1.660  12.640  63.847  1.00 68.96  ? 36  PHE C C   1 
ATOM 5719  O O   . PHE C 1 42  ? -2.124  13.481  63.073  1.00 68.41  ? 36  PHE C O   1 
ATOM 5720  C CB  . PHE C 1 42  ? -0.728  10.457  62.987  1.00 58.75  ? 36  PHE C CB  1 
ATOM 5721  C CG  . PHE C 1 42  ? -1.721  10.430  61.833  1.00 56.31  ? 36  PHE C CG  1 
ATOM 5722  C CD1 . PHE C 1 42  ? -1.345  10.876  60.571  1.00 57.66  ? 36  PHE C CD1 1 
ATOM 5723  C CD2 . PHE C 1 42  ? -3.019  9.960   62.011  1.00 53.53  ? 36  PHE C CD2 1 
ATOM 5724  C CE1 . PHE C 1 42  ? -2.250  10.865  59.519  1.00 59.87  ? 36  PHE C CE1 1 
ATOM 5725  C CE2 . PHE C 1 42  ? -3.911  9.919   60.952  1.00 58.39  ? 36  PHE C CE2 1 
ATOM 5726  C CZ  . PHE C 1 42  ? -3.528  10.382  59.709  1.00 60.81  ? 36  PHE C CZ  1 
ATOM 5727  N N   . GLU C 1 43  ? -2.210  12.343  65.029  1.00 75.08  ? 37  GLU C N   1 
ATOM 5728  C CA  . GLU C 1 43  ? -3.457  12.931  65.488  1.00 68.80  ? 37  GLU C CA  1 
ATOM 5729  C C   . GLU C 1 43  ? -3.298  14.442  65.635  1.00 56.84  ? 37  GLU C C   1 
ATOM 5730  O O   . GLU C 1 43  ? -4.222  15.184  65.343  1.00 48.65  ? 37  GLU C O   1 
ATOM 5731  C CB  . GLU C 1 43  ? -3.908  12.306  66.812  1.00 76.54  ? 37  GLU C CB  1 
ATOM 5732  C CG  . GLU C 1 43  ? -4.010  10.779  66.798  1.00 76.87  ? 37  GLU C CG  1 
ATOM 5733  C CD  . GLU C 1 43  ? -2.729  10.073  67.218  1.00 74.95  ? 37  GLU C CD  1 
ATOM 5734  O OE1 . GLU C 1 43  ? -1.708  10.209  66.507  1.00 66.02  ? 37  GLU C OE1 1 
ATOM 5735  O OE2 . GLU C 1 43  ? -2.747  9.404   68.275  1.00 76.68  ? 37  GLU C OE2 1 
ATOM 5736  N N   . ASP C 1 44  ? -2.138  14.902  66.107  1.00 61.21  ? 38  ASP C N   1 
ATOM 5737  C CA  . ASP C 1 44  ? -1.899  16.333  66.207  1.00 71.89  ? 38  ASP C CA  1 
ATOM 5738  C C   . ASP C 1 44  ? -2.075  16.973  64.832  1.00 74.21  ? 38  ASP C C   1 
ATOM 5739  O O   . ASP C 1 44  ? -2.933  17.840  64.650  1.00 76.41  ? 38  ASP C O   1 
ATOM 5740  C CB  . ASP C 1 44  ? -0.526  16.660  66.780  1.00 78.51  ? 38  ASP C CB  1 
ATOM 5741  C CG  . ASP C 1 44  ? -0.419  16.685  68.298  1.00 78.61  ? 38  ASP C CG  1 
ATOM 5742  O OD1 . ASP C 1 44  ? -1.398  16.294  68.969  1.00 73.38  ? 38  ASP C OD1 1 
ATOM 5743  O OD2 . ASP C 1 44  ? 0.642   17.117  68.796  1.00 80.51  ? 38  ASP C OD2 1 
ATOM 5744  N N   . HIS C 1 45  ? -1.253  16.516  63.877  1.00 66.96  ? 39  HIS C N   1 
ATOM 5745  C CA  . HIS C 1 45  ? -1.161  17.117  62.558  1.00 57.55  ? 39  HIS C CA  1 
ATOM 5746  C C   . HIS C 1 45  ? -2.520  17.126  61.869  1.00 51.77  ? 39  HIS C C   1 
ATOM 5747  O O   . HIS C 1 45  ? -2.898  18.131  61.279  1.00 52.20  ? 39  HIS C O   1 
ATOM 5748  C CB  . HIS C 1 45  ? -0.129  16.367  61.723  1.00 56.46  ? 39  HIS C CB  1 
ATOM 5749  C CG  . HIS C 1 45  ? 1.252   16.626  62.183  1.00 55.49  ? 39  HIS C CG  1 
ATOM 5750  N ND1 . HIS C 1 45  ? 1.728   17.911  62.296  1.00 56.61  ? 39  HIS C ND1 1 
ATOM 5751  C CD2 . HIS C 1 45  ? 2.260   15.812  62.503  1.00 54.68  ? 39  HIS C CD2 1 
ATOM 5752  C CE1 . HIS C 1 45  ? 2.990   17.859  62.687  1.00 61.34  ? 39  HIS C CE1 1 
ATOM 5753  N NE2 . HIS C 1 45  ? 3.335   16.592  62.821  1.00 59.64  ? 39  HIS C NE2 1 
ATOM 5754  N N   . VAL C 1 46  ? -3.260  16.020  61.964  1.00 45.36  ? 40  VAL C N   1 
ATOM 5755  C CA  . VAL C 1 46  ? -4.588  15.974  61.379  1.00 46.59  ? 40  VAL C CA  1 
ATOM 5756  C C   . VAL C 1 46  ? -5.442  17.134  61.887  1.00 48.76  ? 40  VAL C C   1 
ATOM 5757  O O   . VAL C 1 46  ? -6.083  17.791  61.081  1.00 48.46  ? 40  VAL C O   1 
ATOM 5758  C CB  . VAL C 1 46  ? -5.290  14.636  61.640  1.00 46.04  ? 40  VAL C CB  1 
ATOM 5759  C CG1 . VAL C 1 46  ? -6.749  14.690  61.203  1.00 44.74  ? 40  VAL C CG1 1 
ATOM 5760  C CG2 . VAL C 1 46  ? -4.540  13.494  60.964  1.00 46.72  ? 40  VAL C CG2 1 
ATOM 5761  N N   . LYS C 1 47  ? -5.432  17.379  63.206  1.00 54.04  ? 41  LYS C N   1 
ATOM 5762  C CA  . LYS C 1 47  ? -6.211  18.436  63.838  1.00 61.29  ? 41  LYS C CA  1 
ATOM 5763  C C   . LYS C 1 47  ? -5.850  19.825  63.295  1.00 67.87  ? 41  LYS C C   1 
ATOM 5764  O O   . LYS C 1 47  ? -6.738  20.628  63.014  1.00 68.90  ? 41  LYS C O   1 
ATOM 5765  C CB  . LYS C 1 47  ? -5.978  18.468  65.353  1.00 64.11  ? 41  LYS C CB  1 
ATOM 5766  C CG  . LYS C 1 47  ? -7.018  19.258  66.156  1.00 69.97  ? 41  LYS C CG  1 
ATOM 5767  C CD  . LYS C 1 47  ? -6.467  19.946  67.404  1.00 78.26  ? 41  LYS C CD  1 
ATOM 5768  C CE  . LYS C 1 47  ? -7.437  20.044  68.549  1.00 91.84  ? 41  LYS C CE  1 
ATOM 5769  N NZ  . LYS C 1 47  ? -8.648  20.800  68.225  1.00 105.37 ? 41  LYS C NZ  1 
ATOM 5770  N N   . LEU C 1 48  ? -4.550  20.127  63.170  1.00 69.03  ? 42  LEU C N   1 
ATOM 5771  C CA  . LEU C 1 48  ? -4.108  21.438  62.703  1.00 70.45  ? 42  LEU C CA  1 
ATOM 5772  C C   . LEU C 1 48  ? -4.514  21.668  61.245  1.00 66.78  ? 42  LEU C C   1 
ATOM 5773  O O   . LEU C 1 48  ? -4.786  22.804  60.846  1.00 57.96  ? 42  LEU C O   1 
ATOM 5774  C CB  . LEU C 1 48  ? -2.596  21.584  62.846  1.00 70.03  ? 42  LEU C CB  1 
ATOM 5775  C CG  . LEU C 1 48  ? -2.062  21.753  64.268  1.00 70.51  ? 42  LEU C CG  1 
ATOM 5776  C CD1 . LEU C 1 48  ? -2.211  20.503  65.106  1.00 69.50  ? 42  LEU C CD1 1 
ATOM 5777  C CD2 . LEU C 1 48  ? -0.604  22.140  64.162  1.00 79.22  ? 42  LEU C CD2 1 
ATOM 5778  N N   . VAL C 1 49  ? -4.516  20.583  60.456  1.00 60.65  ? 43  VAL C N   1 
ATOM 5779  C CA  . VAL C 1 49  ? -4.792  20.660  59.035  1.00 57.08  ? 43  VAL C CA  1 
ATOM 5780  C C   . VAL C 1 49  ? -6.282  20.871  58.829  1.00 58.74  ? 43  VAL C C   1 
ATOM 5781  O O   . VAL C 1 49  ? -6.675  21.579  57.911  1.00 75.17  ? 43  VAL C O   1 
ATOM 5782  C CB  . VAL C 1 49  ? -4.307  19.432  58.251  1.00 57.09  ? 43  VAL C CB  1 
ATOM 5783  C CG1 . VAL C 1 49  ? -4.966  19.332  56.872  1.00 59.21  ? 43  VAL C CG1 1 
ATOM 5784  C CG2 . VAL C 1 49  ? -2.784  19.407  58.144  1.00 57.70  ? 43  VAL C CG2 1 
ATOM 5785  N N   . ASN C 1 50  ? -7.109  20.247  59.663  1.00 59.80  ? 44  ASN C N   1 
ATOM 5786  C CA  . ASN C 1 50  ? -8.541  20.473  59.566  1.00 63.19  ? 44  ASN C CA  1 
ATOM 5787  C C   . ASN C 1 50  ? -8.837  21.920  59.930  1.00 62.84  ? 44  ASN C C   1 
ATOM 5788  O O   . ASN C 1 50  ? -9.734  22.531  59.357  1.00 72.69  ? 44  ASN C O   1 
ATOM 5789  C CB  . ASN C 1 50  ? -9.353  19.525  60.437  1.00 61.93  ? 44  ASN C CB  1 
ATOM 5790  C CG  . ASN C 1 50  ? -9.215  18.088  60.005  1.00 63.17  ? 44  ASN C CG  1 
ATOM 5791  O OD1 . ASN C 1 50  ? -8.867  17.794  58.851  1.00 67.32  ? 44  ASN C OD1 1 
ATOM 5792  N ND2 . ASN C 1 50  ? -9.473  17.183  60.935  1.00 66.64  ? 44  ASN C ND2 1 
ATOM 5793  N N   . GLU C 1 51  ? -8.062  22.467  60.867  1.00 60.28  ? 45  GLU C N   1 
ATOM 5794  C CA  . GLU C 1 51  ? -8.315  23.816  61.343  1.00 67.62  ? 45  GLU C CA  1 
ATOM 5795  C C   . GLU C 1 51  ? -7.917  24.839  60.288  1.00 61.96  ? 45  GLU C C   1 
ATOM 5796  O O   . GLU C 1 51  ? -8.609  25.838  60.116  1.00 66.69  ? 45  GLU C O   1 
ATOM 5797  C CB  . GLU C 1 51  ? -7.641  24.075  62.690  1.00 69.90  ? 45  GLU C CB  1 
ATOM 5798  C CG  . GLU C 1 51  ? -8.399  23.402  63.832  1.00 67.36  ? 45  GLU C CG  1 
ATOM 5799  C CD  . GLU C 1 51  ? -7.689  23.540  65.153  1.00 65.73  ? 45  GLU C CD  1 
ATOM 5800  O OE1 . GLU C 1 51  ? -6.732  24.331  65.129  1.00 68.44  ? 45  GLU C OE1 1 
ATOM 5801  O OE2 . GLU C 1 51  ? -8.046  22.880  66.153  1.00 63.79  ? 45  GLU C OE2 1 
ATOM 5802  N N   . VAL C 1 52  ? -6.817  24.580  59.579  1.00 60.90  ? 46  VAL C N   1 
ATOM 5803  C CA  . VAL C 1 52  ? -6.393  25.466  58.505  1.00 62.50  ? 46  VAL C CA  1 
ATOM 5804  C C   . VAL C 1 52  ? -7.405  25.413  57.359  1.00 59.98  ? 46  VAL C C   1 
ATOM 5805  O O   . VAL C 1 52  ? -7.908  26.454  56.935  1.00 58.45  ? 46  VAL C O   1 
ATOM 5806  C CB  . VAL C 1 52  ? -4.979  25.132  58.001  1.00 61.95  ? 46  VAL C CB  1 
ATOM 5807  C CG1 . VAL C 1 52  ? -4.654  25.915  56.743  1.00 66.70  ? 46  VAL C CG1 1 
ATOM 5808  C CG2 . VAL C 1 52  ? -3.911  25.380  59.059  1.00 61.61  ? 46  VAL C CG2 1 
ATOM 5809  N N   . THR C 1 53  ? -7.668  24.197  56.855  1.00 54.63  ? 47  THR C N   1 
ATOM 5810  C CA  . THR C 1 53  ? -8.650  23.972  55.807  1.00 54.34  ? 47  THR C CA  1 
ATOM 5811  C C   . THR C 1 53  ? -9.915  24.764  56.129  1.00 55.77  ? 47  THR C C   1 
ATOM 5812  O O   . THR C 1 53  ? -10.338 25.589  55.331  1.00 58.99  ? 47  THR C O   1 
ATOM 5813  C CB  . THR C 1 53  ? -8.916  22.474  55.655  1.00 57.21  ? 47  THR C CB  1 
ATOM 5814  O OG1 . THR C 1 53  ? -7.665  21.910  55.274  1.00 59.69  ? 47  THR C OG1 1 
ATOM 5815  C CG2 . THR C 1 53  ? -9.932  22.140  54.578  1.00 57.24  ? 47  THR C CG2 1 
ATOM 5816  N N   . GLU C 1 54  ? -10.498 24.552  57.312  1.00 59.69  ? 48  GLU C N   1 
ATOM 5817  C CA  . GLU C 1 54  ? -11.755 25.206  57.650  1.00 67.24  ? 48  GLU C CA  1 
ATOM 5818  C C   . GLU C 1 54  ? -11.603 26.721  57.556  1.00 64.97  ? 48  GLU C C   1 
ATOM 5819  O O   . GLU C 1 54  ? -12.560 27.428  57.229  1.00 63.45  ? 48  GLU C O   1 
ATOM 5820  C CB  . GLU C 1 54  ? -12.297 24.810  59.027  1.00 73.78  ? 48  GLU C CB  1 
ATOM 5821  C CG  . GLU C 1 54  ? -13.423 23.782  58.945  1.00 83.33  ? 48  GLU C CG  1 
ATOM 5822  C CD  . GLU C 1 54  ? -14.630 24.287  58.172  1.00 96.76  ? 48  GLU C CD  1 
ATOM 5823  O OE1 . GLU C 1 54  ? -14.711 25.512  57.895  1.00 97.78  ? 48  GLU C OE1 1 
ATOM 5824  O OE2 . GLU C 1 54  ? -15.482 23.439  57.828  1.00 107.86 ? 48  GLU C OE2 1 
ATOM 5825  N N   . PHE C 1 55  ? -10.390 27.198  57.850  1.00 59.72  ? 49  PHE C N   1 
ATOM 5826  C CA  . PHE C 1 55  ? -10.093 28.620  57.847  1.00 64.15  ? 49  PHE C CA  1 
ATOM 5827  C C   . PHE C 1 55  ? -9.888  29.140  56.424  1.00 67.68  ? 49  PHE C C   1 
ATOM 5828  O O   . PHE C 1 55  ? -10.237 30.282  56.126  1.00 66.60  ? 49  PHE C O   1 
ATOM 5829  C CB  . PHE C 1 55  ? -8.858  28.906  58.706  1.00 63.01  ? 49  PHE C CB  1 
ATOM 5830  C CG  . PHE C 1 55  ? -8.389  30.343  58.564  1.00 62.85  ? 49  PHE C CG  1 
ATOM 5831  C CD1 . PHE C 1 55  ? -9.194  31.392  58.992  1.00 68.37  ? 49  PHE C CD1 1 
ATOM 5832  C CD2 . PHE C 1 55  ? -7.167  30.641  57.983  1.00 64.60  ? 49  PHE C CD2 1 
ATOM 5833  C CE1 . PHE C 1 55  ? -8.778  32.706  58.858  1.00 72.86  ? 49  PHE C CE1 1 
ATOM 5834  C CE2 . PHE C 1 55  ? -6.750  31.955  57.861  1.00 69.52  ? 49  PHE C CE2 1 
ATOM 5835  C CZ  . PHE C 1 55  ? -7.556  32.984  58.294  1.00 71.48  ? 49  PHE C CZ  1 
ATOM 5836  N N   . ALA C 1 56  ? -9.278  28.321  55.560  1.00 63.34  ? 50  ALA C N   1 
ATOM 5837  C CA  . ALA C 1 56  ? -9.154  28.671  54.157  1.00 58.54  ? 50  ALA C CA  1 
ATOM 5838  C C   . ALA C 1 56  ? -10.543 28.846  53.546  1.00 56.56  ? 50  ALA C C   1 
ATOM 5839  O O   . ALA C 1 56  ? -10.795 29.830  52.858  1.00 61.78  ? 50  ALA C O   1 
ATOM 5840  C CB  . ALA C 1 56  ? -8.362  27.613  53.431  1.00 59.31  ? 50  ALA C CB  1 
ATOM 5841  N N   . LYS C 1 57  ? -11.445 27.901  53.829  1.00 52.49  ? 51  LYS C N   1 
ATOM 5842  C CA  . LYS C 1 57  ? -12.792 27.913  53.287  1.00 53.41  ? 51  LYS C CA  1 
ATOM 5843  C C   . LYS C 1 57  ? -13.492 29.243  53.564  1.00 56.36  ? 51  LYS C C   1 
ATOM 5844  O O   . LYS C 1 57  ? -14.249 29.710  52.712  1.00 60.79  ? 51  LYS C O   1 
ATOM 5845  C CB  . LYS C 1 57  ? -13.612 26.761  53.873  1.00 54.49  ? 51  LYS C CB  1 
ATOM 5846  C CG  . LYS C 1 57  ? -13.232 25.387  53.359  1.00 55.32  ? 51  LYS C CG  1 
ATOM 5847  C CD  . LYS C 1 57  ? -13.865 24.225  54.111  1.00 55.45  ? 51  LYS C CD  1 
ATOM 5848  C CE  . LYS C 1 57  ? -13.449 22.930  53.491  1.00 56.80  ? 51  LYS C CE  1 
ATOM 5849  N NZ  . LYS C 1 57  ? -13.562 21.815  54.433  1.00 60.60  ? 51  LYS C NZ  1 
ATOM 5850  N N   . THR C 1 58  ? -13.250 29.834  54.747  1.00 55.73  ? 52  THR C N   1 
ATOM 5851  C CA  . THR C 1 58  ? -13.898 31.084  55.123  1.00 59.60  ? 52  THR C CA  1 
ATOM 5852  C C   . THR C 1 58  ? -13.312 32.226  54.296  1.00 61.31  ? 52  THR C C   1 
ATOM 5853  O O   . THR C 1 58  ? -13.986 33.234  54.082  1.00 70.02  ? 52  THR C O   1 
ATOM 5854  C CB  . THR C 1 58  ? -13.809 31.366  56.630  1.00 66.66  ? 52  THR C CB  1 
ATOM 5855  O OG1 . THR C 1 58  ? -12.450 31.527  57.029  1.00 64.43  ? 52  THR C OG1 1 
ATOM 5856  C CG2 . THR C 1 58  ? -14.467 30.284  57.473  1.00 69.63  ? 52  THR C CG2 1 
ATOM 5857  N N   . CYS C 1 59  ? -12.073 32.043  53.818  1.00 61.70  ? 53  CYS C N   1 
ATOM 5858  C CA  . CYS C 1 59  ? -11.380 33.033  53.007  1.00 59.55  ? 53  CYS C CA  1 
ATOM 5859  C C   . CYS C 1 59  ? -11.799 32.923  51.546  1.00 55.80  ? 53  CYS C C   1 
ATOM 5860  O O   . CYS C 1 59  ? -11.804 33.917  50.835  1.00 50.38  ? 53  CYS C O   1 
ATOM 5861  C CB  . CYS C 1 59  ? -9.872  32.868  53.124  1.00 65.47  ? 53  CYS C CB  1 
ATOM 5862  S SG  . CYS C 1 59  ? -9.340  32.677  54.844  1.00 80.65  ? 53  CYS C SG  1 
ATOM 5863  N N   . VAL C 1 60  ? -12.141 31.716  51.091  1.00 63.26  ? 54  VAL C N   1 
ATOM 5864  C CA  . VAL C 1 60  ? -12.674 31.547  49.747  1.00 70.26  ? 54  VAL C CA  1 
ATOM 5865  C C   . VAL C 1 60  ? -14.074 32.156  49.701  1.00 73.94  ? 54  VAL C C   1 
ATOM 5866  O O   . VAL C 1 60  ? -14.495 32.687  48.671  1.00 84.60  ? 54  VAL C O   1 
ATOM 5867  C CB  . VAL C 1 60  ? -12.674 30.070  49.310  1.00 71.38  ? 54  VAL C CB  1 
ATOM 5868  C CG1 . VAL C 1 60  ? -13.344 29.854  47.957  1.00 70.82  ? 54  VAL C CG1 1 
ATOM 5869  C CG2 . VAL C 1 60  ? -11.263 29.502  49.285  1.00 76.24  ? 54  VAL C CG2 1 
ATOM 5870  N N   . ALA C 1 61  ? -14.780 32.093  50.834  1.00 64.98  ? 55  ALA C N   1 
ATOM 5871  C CA  . ALA C 1 61  ? -16.087 32.707  50.949  1.00 62.60  ? 55  ALA C CA  1 
ATOM 5872  C C   . ALA C 1 61  ? -15.958 34.226  50.953  1.00 65.04  ? 55  ALA C C   1 
ATOM 5873  O O   . ALA C 1 61  ? -16.856 34.914  50.474  1.00 67.74  ? 55  ALA C O   1 
ATOM 5874  C CB  . ALA C 1 61  ? -16.772 32.218  52.195  1.00 62.48  ? 55  ALA C CB  1 
ATOM 5875  N N   . ASP C 1 62  ? -14.907 34.720  51.615  1.00 67.45  ? 56  ASP C N   1 
ATOM 5876  C CA  . ASP C 1 62  ? -14.678 36.183  51.761  1.00 74.75  ? 56  ASP C CA  1 
ATOM 5877  C C   . ASP C 1 62  ? -13.205 36.483  52.043  1.00 76.18  ? 56  ASP C C   1 
ATOM 5878  O O   . ASP C 1 62  ? -12.792 36.296  53.193  1.00 68.66  ? 56  ASP C O   1 
ATOM 5879  C CB  . ASP C 1 62  ? -15.483 36.779  52.896  1.00 78.27  ? 56  ASP C CB  1 
ATOM 5880  C CG  . ASP C 1 62  ? -15.517 38.297  52.948  1.00 85.81  ? 56  ASP C CG  1 
ATOM 5881  O OD1 . ASP C 1 62  ? -14.900 38.928  52.069  1.00 89.39  ? 56  ASP C OD1 1 
ATOM 5882  O OD2 . ASP C 1 62  ? -16.161 38.837  53.866  1.00 102.31 ? 56  ASP C OD2 1 
ATOM 5883  N N   . GLU C 1 63  ? -12.479 37.036  51.079  1.00 79.15  ? 57  GLU C N   1 
ATOM 5884  C CA  . GLU C 1 63  ? -11.039 37.409  51.191  1.00 83.75  ? 57  GLU C CA  1 
ATOM 5885  C C   . GLU C 1 63  ? -10.927 38.473  52.273  1.00 78.99  ? 57  GLU C C   1 
ATOM 5886  O O   . GLU C 1 63  ? -9.790  38.681  52.734  1.00 66.04  ? 57  GLU C O   1 
ATOM 5887  C CB  . GLU C 1 63  ? -10.540 37.841  49.816  1.00 94.32  ? 57  GLU C CB  1 
ATOM 5888  C CG  . GLU C 1 63  ? -10.372 36.685  48.834  1.00 99.56  ? 57  GLU C CG  1 
ATOM 5889  C CD  . GLU C 1 63  ? -9.751  37.062  47.500  1.00 101.81 ? 57  GLU C CD  1 
ATOM 5890  O OE1 . GLU C 1 63  ? -10.121 38.119  46.952  1.00 98.32  ? 57  GLU C OE1 1 
ATOM 5891  O OE2 . GLU C 1 63  ? -8.900  36.295  47.003  1.00 93.86  ? 57  GLU C OE2 1 
ATOM 5892  N N   A SER C 1 64  ? -11.936 39.346  52.365  0.42 79.84  ? 58  SER C N   1 
ATOM 5893  N N   B SER C 1 64  ? -11.911 39.361  52.345  0.58 81.15  ? 58  SER C N   1 
ATOM 5894  C CA  A SER C 1 64  ? -11.871 40.464  53.345  0.42 80.72  ? 58  SER C CA  1 
ATOM 5895  C CA  B SER C 1 64  ? -11.921 40.470  53.335  0.58 82.68  ? 58  SER C CA  1 
ATOM 5896  C C   A SER C 1 64  ? -12.116 40.000  54.791  0.42 85.96  ? 58  SER C C   1 
ATOM 5897  C C   B SER C 1 64  ? -11.922 39.903  54.757  0.58 88.01  ? 58  SER C C   1 
ATOM 5898  O O   A SER C 1 64  ? -12.123 40.878  55.678  0.42 95.33  ? 58  SER C O   1 
ATOM 5899  O O   B SER C 1 64  ? -11.578 40.680  55.668  0.58 100.06 ? 58  SER C O   1 
ATOM 5900  C CB  A SER C 1 64  ? -12.823 41.561  52.960  0.42 75.05  ? 58  SER C CB  1 
ATOM 5901  C CB  B SER C 1 64  ? -13.064 41.411  53.095  0.58 76.37  ? 58  SER C CB  1 
ATOM 5902  O OG  A SER C 1 64  ? -12.220 42.434  52.017  0.42 69.05  ? 58  SER C OG  1 
ATOM 5903  O OG  B SER C 1 64  ? -14.248 40.947  53.728  0.58 71.37  ? 58  SER C OG  1 
ATOM 5904  N N   . ALA C 1 65  ? -12.562 38.755  54.984  1.00 85.60  ? 59  ALA C N   1 
ATOM 5905  C CA  . ALA C 1 65  ? -12.723 38.238  56.364  1.00 84.15  ? 59  ALA C CA  1 
ATOM 5906  C C   . ALA C 1 65  ? -11.355 38.046  56.996  1.00 94.52  ? 59  ALA C C   1 
ATOM 5907  O O   . ALA C 1 65  ? -10.407 37.649  56.300  1.00 92.83  ? 59  ALA C O   1 
ATOM 5908  C CB  . ALA C 1 65  ? -13.440 36.927  56.329  1.00 77.93  ? 59  ALA C CB  1 
ATOM 5909  N N   . GLU C 1 66  ? -11.246 38.359  58.293  1.00 108.05 ? 60  GLU C N   1 
ATOM 5910  C CA  . GLU C 1 66  ? -9.931  38.528  58.964  1.00 107.57 ? 60  GLU C CA  1 
ATOM 5911  C C   . GLU C 1 66  ? -8.944  37.376  59.096  1.00 93.94  ? 60  GLU C C   1 
ATOM 5912  O O   . GLU C 1 66  ? -9.372  36.251  59.415  1.00 75.15  ? 60  GLU C O   1 
ATOM 5913  C CB  . GLU C 1 66  ? -10.179 38.931  60.414  1.00 117.88 ? 60  GLU C CB  1 
ATOM 5914  C CG  . GLU C 1 66  ? -9.276  40.070  60.890  1.00 134.87 ? 60  GLU C CG  1 
ATOM 5915  C CD  . GLU C 1 66  ? -8.167  40.591  59.984  1.00 144.18 ? 60  GLU C CD  1 
ATOM 5916  O OE1 . GLU C 1 66  ? -8.428  41.516  59.187  1.00 164.07 ? 60  GLU C OE1 1 
ATOM 5917  O OE2 . GLU C 1 66  ? -7.028  40.093  60.088  1.00 111.26 ? 60  GLU C OE2 1 
ATOM 5918  N N   . ASN C 1 67  ? -7.669  37.722  58.898  1.00 95.28  ? 61  ASN C N   1 
ATOM 5919  C CA  . ASN C 1 67  ? -6.488  36.831  59.007  1.00 87.81  ? 61  ASN C CA  1 
ATOM 5920  C C   . ASN C 1 67  ? -6.363  36.147  57.655  1.00 77.36  ? 61  ASN C C   1 
ATOM 5921  O O   . ASN C 1 67  ? -5.356  35.485  57.417  1.00 67.39  ? 61  ASN C O   1 
ATOM 5922  C CB  . ASN C 1 67  ? -6.584  35.907  60.214  1.00 92.05  ? 61  ASN C CB  1 
ATOM 5923  C CG  . ASN C 1 67  ? -6.839  36.646  61.503  1.00 88.26  ? 61  ASN C CG  1 
ATOM 5924  O OD1 . ASN C 1 67  ? -6.376  37.777  61.674  1.00 79.92  ? 61  ASN C OD1 1 
ATOM 5925  N ND2 . ASN C 1 67  ? -7.567  36.026  62.419  1.00 89.12  ? 61  ASN C ND2 1 
ATOM 5926  N N   . CYS C 1 68  ? -7.314  36.402  56.771  1.00 73.20  ? 62  CYS C N   1 
ATOM 5927  C CA  . CYS C 1 68  ? -7.205  35.896  55.383  1.00 76.95  ? 62  CYS C CA  1 
ATOM 5928  C C   . CYS C 1 68  ? -5.983  36.622  54.789  1.00 76.85  ? 62  CYS C C   1 
ATOM 5929  O O   . CYS C 1 68  ? -5.233  35.986  54.032  1.00 88.96  ? 62  CYS C O   1 
ATOM 5930  C CB  . CYS C 1 68  ? -8.606  35.803  54.767  1.00 79.30  ? 62  CYS C CB  1 
ATOM 5931  S SG  . CYS C 1 68  ? -9.677  34.580  55.586  1.00 79.89  ? 62  CYS C SG  1 
ATOM 5932  N N   . ASP C 1 69  ? -5.816  37.898  55.112  1.00 72.26  ? 63  ASP C N   1 
ATOM 5933  C CA  . ASP C 1 69  ? -4.733  38.781  54.586  1.00 77.35  ? 63  ASP C CA  1 
ATOM 5934  C C   . ASP C 1 69  ? -3.355  38.279  54.994  1.00 74.52  ? 63  ASP C C   1 
ATOM 5935  O O   . ASP C 1 69  ? -2.417  38.402  54.191  1.00 78.24  ? 63  ASP C O   1 
ATOM 5936  C CB  . ASP C 1 69  ? -4.930  40.229  55.002  1.00 78.67  ? 63  ASP C CB  1 
ATOM 5937  C CG  . ASP C 1 69  ? -4.980  40.500  56.497  1.00 82.80  ? 63  ASP C CG  1 
ATOM 5938  O OD1 . ASP C 1 69  ? -5.488  39.632  57.232  1.00 86.07  ? 63  ASP C OD1 1 
ATOM 5939  O OD2 . ASP C 1 69  ? -4.519  41.583  56.907  1.00 82.45  ? 63  ASP C OD2 1 
ATOM 5940  N N   . LYS C 1 70  ? -3.221  37.760  56.199  1.00 68.98  ? 64  LYS C N   1 
ATOM 5941  C CA  . LYS C 1 70  ? -1.896  37.457  56.769  1.00 65.26  ? 64  LYS C CA  1 
ATOM 5942  C C   . LYS C 1 70  ? -1.151  36.402  55.958  1.00 63.57  ? 64  LYS C C   1 
ATOM 5943  O O   . LYS C 1 70  ? -1.800  35.551  55.336  1.00 55.71  ? 64  LYS C O   1 
ATOM 5944  C CB  . LYS C 1 70  ? -2.176  36.948  58.182  1.00 67.05  ? 64  LYS C CB  1 
ATOM 5945  C CG  . LYS C 1 70  ? -2.581  37.985  59.210  1.00 69.88  ? 64  LYS C CG  1 
ATOM 5946  C CD  . LYS C 1 70  ? -2.132  37.583  60.608  1.00 80.88  ? 64  LYS C CD  1 
ATOM 5947  C CE  . LYS C 1 70  ? -3.227  37.615  61.621  1.00 84.04  ? 64  LYS C CE  1 
ATOM 5948  N NZ  . LYS C 1 70  ? -3.505  36.283  62.162  1.00 90.96  ? 64  LYS C NZ  1 
ATOM 5949  N N   . SER C 1 71  ? 0.172   36.528  55.910  1.00 61.20  ? 65  SER C N   1 
ATOM 5950  C CA  . SER C 1 71  ? 1.045   35.658  55.093  1.00 57.41  ? 65  SER C CA  1 
ATOM 5951  C C   . SER C 1 71  ? 0.979   34.218  55.576  1.00 60.60  ? 65  SER C C   1 
ATOM 5952  O O   . SER C 1 71  ? 0.727   33.997  56.761  1.00 60.15  ? 65  SER C O   1 
ATOM 5953  C CB  . SER C 1 71  ? 2.446   36.128  55.199  1.00 59.60  ? 65  SER C CB  1 
ATOM 5954  O OG  . SER C 1 71  ? 3.174   35.348  56.134  1.00 68.96  ? 65  SER C OG  1 
ATOM 5955  N N   . LEU C 1 72  ? 1.112   33.278  54.653  1.00 63.12  ? 66  LEU C N   1 
ATOM 5956  C CA  . LEU C 1 72  ? 0.930   31.865  55.028  1.00 63.84  ? 66  LEU C CA  1 
ATOM 5957  C C   . LEU C 1 72  ? 1.982   31.476  56.062  1.00 66.18  ? 66  LEU C C   1 
ATOM 5958  O O   . LEU C 1 72  ? 1.623   30.809  57.040  1.00 58.63  ? 66  LEU C O   1 
ATOM 5959  C CB  . LEU C 1 72  ? 1.146   31.116  53.721  1.00 61.71  ? 66  LEU C CB  1 
ATOM 5960  C CG  . LEU C 1 72  ? 0.153   31.416  52.596  1.00 67.27  ? 66  LEU C CG  1 
ATOM 5961  C CD1 . LEU C 1 72  ? 0.297   30.427  51.457  1.00 69.33  ? 66  LEU C CD1 1 
ATOM 5962  C CD2 . LEU C 1 72  ? -1.250  31.373  53.143  1.00 65.31  ? 66  LEU C CD2 1 
ATOM 5963  N N   . HIS C 1 73  ? 3.211   31.936  55.877  1.00 69.41  ? 67  HIS C N   1 
ATOM 5964  C CA  . HIS C 1 73  ? 4.296   31.597  56.826  1.00 67.54  ? 67  HIS C CA  1 
ATOM 5965  C C   . HIS C 1 73  ? 3.826   32.100  58.180  1.00 64.05  ? 67  HIS C C   1 
ATOM 5966  O O   . HIS C 1 73  ? 4.114   31.485  59.214  1.00 63.07  ? 67  HIS C O   1 
ATOM 5967  C CB  . HIS C 1 73  ? 5.629   32.163  56.333  1.00 67.53  ? 67  HIS C CB  1 
ATOM 5968  C CG  . HIS C 1 73  ? 6.273   31.346  55.268  1.00 71.02  ? 67  HIS C CG  1 
ATOM 5969  N ND1 . HIS C 1 73  ? 6.423   29.981  55.364  1.00 74.58  ? 67  HIS C ND1 1 
ATOM 5970  C CD2 . HIS C 1 73  ? 6.798   31.694  54.093  1.00 75.35  ? 67  HIS C CD2 1 
ATOM 5971  C CE1 . HIS C 1 73  ? 7.022   29.531  54.274  1.00 77.46  ? 67  HIS C CE1 1 
ATOM 5972  N NE2 . HIS C 1 73  ? 7.260   30.556  53.489  1.00 78.18  ? 67  HIS C NE2 1 
ATOM 5973  N N   . THR C 1 74  ? 3.105   33.209  58.159  1.00 65.97  ? 68  THR C N   1 
ATOM 5974  C CA  . THR C 1 74  ? 2.523   33.697  59.401  1.00 74.56  ? 68  THR C CA  1 
ATOM 5975  C C   . THR C 1 74  ? 1.364   32.784  59.819  1.00 68.49  ? 68  THR C C   1 
ATOM 5976  O O   . THR C 1 74  ? 1.283   32.370  60.972  1.00 63.52  ? 68  THR C O   1 
ATOM 5977  C CB  . THR C 1 74  ? 2.122   35.168  59.223  1.00 81.09  ? 68  THR C CB  1 
ATOM 5978  O OG1 . THR C 1 74  ? 3.351   35.891  59.290  1.00 82.15  ? 68  THR C OG1 1 
ATOM 5979  C CG2 . THR C 1 74  ? 1.167   35.683  60.289  1.00 78.87  ? 68  THR C CG2 1 
ATOM 5980  N N   . LEU C 1 75  ? 0.479   32.471  58.892  1.00 65.19  ? 69  LEU C N   1 
ATOM 5981  C CA  . LEU C 1 75  ? -0.682  31.668  59.306  1.00 65.51  ? 69  LEU C CA  1 
ATOM 5982  C C   . LEU C 1 75  ? -0.181  30.328  59.842  1.00 68.85  ? 69  LEU C C   1 
ATOM 5983  O O   . LEU C 1 75  ? -0.473  30.014  61.001  1.00 70.83  ? 69  LEU C O   1 
ATOM 5984  C CB  . LEU C 1 75  ? -1.564  31.535  58.075  1.00 71.02  ? 69  LEU C CB  1 
ATOM 5985  C CG  . LEU C 1 75  ? -2.397  32.774  57.741  1.00 82.08  ? 69  LEU C CG  1 
ATOM 5986  C CD1 . LEU C 1 75  ? -3.098  32.618  56.410  1.00 88.53  ? 69  LEU C CD1 1 
ATOM 5987  C CD2 . LEU C 1 75  ? -3.396  33.026  58.852  1.00 83.15  ? 69  LEU C CD2 1 
ATOM 5988  N N   . PHE C 1 76  ? 0.567   29.584  59.036  1.00 76.65  ? 70  PHE C N   1 
ATOM 5989  C CA  . PHE C 1 76  ? 1.035   28.230  59.445  1.00 78.42  ? 70  PHE C CA  1 
ATOM 5990  C C   . PHE C 1 76  ? 1.945   28.314  60.656  1.00 76.14  ? 70  PHE C C   1 
ATOM 5991  O O   . PHE C 1 76  ? 1.821   27.497  61.571  1.00 72.45  ? 70  PHE C O   1 
ATOM 5992  C CB  . PHE C 1 76  ? 1.763   27.571  58.274  1.00 77.30  ? 70  PHE C CB  1 
ATOM 5993  C CG  . PHE C 1 76  ? 0.893   27.349  57.045  1.00 85.14  ? 70  PHE C CG  1 
ATOM 5994  C CD1 . PHE C 1 76  ? -0.492  27.411  57.129  1.00 84.70  ? 70  PHE C CD1 1 
ATOM 5995  C CD2 . PHE C 1 76  ? 1.462   27.077  55.808  1.00 91.11  ? 70  PHE C CD2 1 
ATOM 5996  C CE1 . PHE C 1 76  ? -1.281  27.215  56.010  1.00 80.84  ? 70  PHE C CE1 1 
ATOM 5997  C CE2 . PHE C 1 76  ? 0.667   26.879  54.693  1.00 95.21  ? 70  PHE C CE2 1 
ATOM 5998  C CZ  . PHE C 1 76  ? -0.701  26.948  54.797  1.00 88.98  ? 70  PHE C CZ  1 
ATOM 5999  N N   . GLY C 1 77  ? 2.820   29.309  60.686  1.00 78.55  ? 71  GLY C N   1 
ATOM 6000  C CA  . GLY C 1 77  ? 3.770   29.434  61.797  1.00 76.49  ? 71  GLY C CA  1 
ATOM 6001  C C   . GLY C 1 77  ? 2.985   29.645  63.055  1.00 82.93  ? 71  GLY C C   1 
ATOM 6002  O O   . GLY C 1 77  ? 3.358   29.078  64.089  1.00 85.77  ? 71  GLY C O   1 
ATOM 6003  N N   . ASP C 1 78  ? 1.928   30.446  62.974  1.00 88.27  ? 72  ASP C N   1 
ATOM 6004  C CA  . ASP C 1 78  ? 1.058   30.604  64.156  1.00 77.56  ? 72  ASP C CA  1 
ATOM 6005  C C   . ASP C 1 78  ? 0.429   29.265  64.509  1.00 65.50  ? 72  ASP C C   1 
ATOM 6006  O O   . ASP C 1 78  ? 0.462   28.898  65.681  1.00 60.21  ? 72  ASP C O   1 
ATOM 6007  C CB  . ASP C 1 78  ? -0.089  31.529  63.801  1.00 81.49  ? 72  ASP C CB  1 
ATOM 6008  C CG  . ASP C 1 78  ? -0.393  32.661  64.767  1.00 88.35  ? 72  ASP C CG  1 
ATOM 6009  O OD1 . ASP C 1 78  ? -0.230  32.458  65.987  1.00 97.91  ? 72  ASP C OD1 1 
ATOM 6010  O OD2 . ASP C 1 78  ? -0.805  33.735  64.284  1.00 86.84  ? 72  ASP C OD2 1 
ATOM 6011  N N   . LYS C 1 79  ? -0.024  28.513  63.515  1.00 58.01  ? 73  LYS C N   1 
ATOM 6012  C CA  . LYS C 1 79  ? -0.726  27.270  63.886  1.00 54.06  ? 73  LYS C CA  1 
ATOM 6013  C C   . LYS C 1 79  ? 0.261   26.370  64.597  1.00 57.66  ? 73  LYS C C   1 
ATOM 6014  O O   . LYS C 1 79  ? -0.124  25.739  65.584  1.00 65.48  ? 73  LYS C O   1 
ATOM 6015  C CB  . LYS C 1 79  ? -1.262  26.480  62.696  1.00 56.62  ? 73  LYS C CB  1 
ATOM 6016  C CG  . LYS C 1 79  ? -2.771  26.437  62.553  1.00 65.51  ? 73  LYS C CG  1 
ATOM 6017  C CD  . LYS C 1 79  ? -3.493  26.028  63.828  1.00 73.05  ? 73  LYS C CD  1 
ATOM 6018  C CE  . LYS C 1 79  ? -4.781  26.767  63.992  1.00 82.56  ? 73  LYS C CE  1 
ATOM 6019  N NZ  . LYS C 1 79  ? -4.658  27.881  64.935  1.00 88.02  ? 73  LYS C NZ  1 
ATOM 6020  N N   . LEU C 1 80  ? 1.487   26.307  64.089  1.00 58.58  ? 74  LEU C N   1 
ATOM 6021  C CA  . LEU C 1 80  ? 2.403   25.330  64.713  1.00 61.93  ? 74  LEU C CA  1 
ATOM 6022  C C   . LEU C 1 80  ? 2.656   25.708  66.165  1.00 74.31  ? 74  LEU C C   1 
ATOM 6023  O O   . LEU C 1 80  ? 2.647   24.832  67.047  1.00 74.46  ? 74  LEU C O   1 
ATOM 6024  C CB  . LEU C 1 80  ? 3.702   25.385  63.919  1.00 58.28  ? 74  LEU C CB  1 
ATOM 6025  C CG  . LEU C 1 80  ? 3.681   24.722  62.542  1.00 60.25  ? 74  LEU C CG  1 
ATOM 6026  C CD1 . LEU C 1 80  ? 5.097   24.492  62.066  1.00 58.26  ? 74  LEU C CD1 1 
ATOM 6027  C CD2 . LEU C 1 80  ? 2.937   23.411  62.637  1.00 62.13  ? 74  LEU C CD2 1 
ATOM 6028  N N   . CYS C 1 81  ? 2.709   27.000  66.432  1.00 87.43  ? 75  CYS C N   1 
ATOM 6029  C CA  . CYS C 1 81  ? 2.973   27.460  67.813  1.00 93.85  ? 75  CYS C CA  1 
ATOM 6030  C C   . CYS C 1 81  ? 1.665   27.469  68.622  1.00 97.38  ? 75  CYS C C   1 
ATOM 6031  O O   . CYS C 1 81  ? 1.749   27.457  69.860  1.00 107.18 ? 75  CYS C O   1 
ATOM 6032  C CB  . CYS C 1 81  ? 3.665   28.813  67.749  1.00 95.65  ? 75  CYS C CB  1 
ATOM 6033  S SG  . CYS C 1 81  ? 5.206   28.749  66.799  1.00 107.90 ? 75  CYS C SG  1 
ATOM 6034  N N   . THR C 1 82  ? 0.511   27.465  67.956  1.00 95.26  ? 76  THR C N   1 
ATOM 6035  C CA  . THR C 1 82  ? -0.778  27.549  68.667  1.00 97.83  ? 76  THR C CA  1 
ATOM 6036  C C   . THR C 1 82  ? -0.903  26.350  69.522  1.00 97.13  ? 76  THR C C   1 
ATOM 6037  O O   . THR C 1 82  ? -1.472  26.454  70.619  1.00 89.70  ? 76  THR C O   1 
ATOM 6038  C CB  . THR C 1 82  ? -2.003  27.547  67.759  1.00 114.32 ? 76  THR C CB  1 
ATOM 6039  O OG1 . THR C 1 82  ? -1.832  26.415  66.913  1.00 136.23 ? 76  THR C OG1 1 
ATOM 6040  C CG2 . THR C 1 82  ? -2.178  28.844  66.987  1.00 111.66 ? 76  THR C CG2 1 
ATOM 6041  N N   . VAL C 1 83  ? -0.484  25.217  69.000  1.00 109.08 ? 77  VAL C N   1 
ATOM 6042  C CA  . VAL C 1 83  ? -0.759  23.988  69.779  1.00 121.94 ? 77  VAL C CA  1 
ATOM 6043  C C   . VAL C 1 83  ? 0.481   23.423  70.472  1.00 115.78 ? 77  VAL C C   1 
ATOM 6044  O O   . VAL C 1 83  ? 0.336   22.926  71.605  1.00 117.52 ? 77  VAL C O   1 
ATOM 6045  C CB  . VAL C 1 83  ? -1.345  22.992  68.769  1.00 139.19 ? 77  VAL C CB  1 
ATOM 6046  C CG1 . VAL C 1 83  ? -2.803  23.304  68.454  1.00 142.98 ? 77  VAL C CG1 1 
ATOM 6047  C CG2 . VAL C 1 83  ? -0.518  22.959  67.492  1.00 139.73 ? 77  VAL C CG2 1 
ATOM 6048  N N   . ALA C 1 84  ? 1.647   23.501  69.847  1.00 117.29 ? 78  ALA C N   1 
ATOM 6049  C CA  . ALA C 1 84  ? 2.771   22.787  70.494  1.00 131.27 ? 78  ALA C CA  1 
ATOM 6050  C C   . ALA C 1 84  ? 2.976   23.196  71.946  1.00 157.36 ? 78  ALA C C   1 
ATOM 6051  O O   . ALA C 1 84  ? 2.925   24.406  72.248  1.00 176.74 ? 78  ALA C O   1 
ATOM 6052  C CB  . ALA C 1 84  ? 4.033   23.037  69.713  1.00 132.45 ? 78  ALA C CB  1 
ATOM 6053  N N   . THR C 1 85  ? 3.200   22.207  72.821  1.00 158.49 ? 79  THR C N   1 
ATOM 6054  C CA  . THR C 1 85  ? 3.575   22.485  74.216  1.00 141.42 ? 79  THR C CA  1 
ATOM 6055  C C   . THR C 1 85  ? 4.902   23.168  74.166  1.00 143.87 ? 79  THR C C   1 
ATOM 6056  O O   . THR C 1 85  ? 5.124   24.101  74.960  1.00 137.00 ? 79  THR C O   1 
ATOM 6057  C CB  . THR C 1 85  ? 3.685   21.161  74.955  1.00 134.08 ? 79  THR C CB  1 
ATOM 6058  O OG1 . THR C 1 85  ? 4.880   20.583  74.441  1.00 133.52 ? 79  THR C OG1 1 
ATOM 6059  C CG2 . THR C 1 85  ? 2.500   20.252  74.690  1.00 126.89 ? 79  THR C CG2 1 
ATOM 6060  N N   . LEU C 1 86  ? 5.769   22.679  73.277  1.00 152.50 ? 80  LEU C N   1 
ATOM 6061  C CA  . LEU C 1 86  ? 7.120   23.265  73.123  1.00 170.51 ? 80  LEU C CA  1 
ATOM 6062  C C   . LEU C 1 86  ? 7.342   23.563  71.634  1.00 178.29 ? 80  LEU C C   1 
ATOM 6063  O O   . LEU C 1 86  ? 6.606   24.427  71.114  1.00 185.64 ? 80  LEU C O   1 
ATOM 6064  C CB  . LEU C 1 86  ? 8.159   22.286  73.661  1.00 175.34 ? 80  LEU C CB  1 
ATOM 6065  C CG  . LEU C 1 86  ? 9.471   22.896  74.163  1.00 182.85 ? 80  LEU C CG  1 
ATOM 6066  C CD1 . LEU C 1 86  ? 9.214   23.929  75.245  1.00 180.46 ? 80  LEU C CD1 1 
ATOM 6067  C CD2 . LEU C 1 86  ? 10.429  21.822  74.651  1.00 183.25 ? 80  LEU C CD2 1 
ATOM 6068  N N   . ALA C 1 94  ? 11.651  25.317  69.303  1.00 157.95 ? 88  ALA C N   1 
ATOM 6069  C CA  . ALA C 1 94  ? 10.641  25.780  70.281  1.00 144.94 ? 88  ALA C CA  1 
ATOM 6070  C C   . ALA C 1 94  ? 10.946  27.220  70.681  1.00 141.39 ? 88  ALA C C   1 
ATOM 6071  O O   . ALA C 1 94  ? 9.992   27.994  70.895  1.00 143.76 ? 88  ALA C O   1 
ATOM 6072  C CB  . ALA C 1 94  ? 10.640  24.874  71.479  1.00 139.81 ? 88  ALA C CB  1 
ATOM 6073  N N   . ASP C 1 95  ? 12.228  27.568  70.793  1.00 131.86 ? 89  ASP C N   1 
ATOM 6074  C CA  . ASP C 1 95  ? 12.564  28.989  71.069  1.00 126.07 ? 89  ASP C CA  1 
ATOM 6075  C C   . ASP C 1 95  ? 12.052  29.772  69.861  1.00 130.61 ? 89  ASP C C   1 
ATOM 6076  O O   . ASP C 1 95  ? 11.481  30.865  70.052  1.00 134.72 ? 89  ASP C O   1 
ATOM 6077  C CB  . ASP C 1 95  ? 14.024  29.176  71.432  1.00 114.57 ? 89  ASP C CB  1 
ATOM 6078  C CG  . ASP C 1 95  ? 14.959  28.041  71.063  1.00 112.84 ? 89  ASP C CG  1 
ATOM 6079  O OD1 . ASP C 1 95  ? 15.130  27.799  69.852  1.00 108.05 ? 89  ASP C OD1 1 
ATOM 6080  O OD2 . ASP C 1 95  ? 15.514  27.426  71.996  1.00 108.72 ? 89  ASP C OD2 1 
ATOM 6081  N N   . CYS C 1 96  ? 12.226  29.210  68.669  1.00 121.73 ? 90  CYS C N   1 
ATOM 6082  C CA  . CYS C 1 96  ? 11.694  29.832  67.441  1.00 120.13 ? 90  CYS C CA  1 
ATOM 6083  C C   . CYS C 1 96  ? 10.182  29.897  67.525  1.00 116.63 ? 90  CYS C C   1 
ATOM 6084  O O   . CYS C 1 96  ? 9.632   30.935  67.174  1.00 114.18 ? 90  CYS C O   1 
ATOM 6085  C CB  . CYS C 1 96  ? 11.774  28.880  66.275  1.00 113.52 ? 90  CYS C CB  1 
ATOM 6086  S SG  . CYS C 1 96  ? 11.389  27.168  66.712  1.00 100.72 ? 90  CYS C SG  1 
ATOM 6087  N N   . CYS C 1 97  ? 9.551   28.863  68.058  1.00 114.25 ? 91  CYS C N   1 
ATOM 6088  C CA  . CYS C 1 97  ? 8.068   28.754  68.047  1.00 117.11 ? 91  CYS C CA  1 
ATOM 6089  C C   . CYS C 1 97  ? 7.454   29.900  68.824  1.00 127.38 ? 91  CYS C C   1 
ATOM 6090  O O   . CYS C 1 97  ? 6.412   30.413  68.397  1.00 143.18 ? 91  CYS C O   1 
ATOM 6091  C CB  . CYS C 1 97  ? 7.486   27.422  68.479  1.00 112.78 ? 91  CYS C CB  1 
ATOM 6092  S SG  . CYS C 1 97  ? 6.120   27.004  67.369  1.00 108.69 ? 91  CYS C SG  1 
ATOM 6093  N N   . ALA C 1 98  ? 8.078   30.327  69.895  1.00 132.72 ? 92  ALA C N   1 
ATOM 6094  C CA  . ALA C 1 98  ? 7.345   31.291  70.725  1.00 149.94 ? 92  ALA C CA  1 
ATOM 6095  C C   . ALA C 1 98  ? 7.072   32.467  69.802  1.00 155.31 ? 92  ALA C C   1 
ATOM 6096  O O   . ALA C 1 98  ? 5.942   32.992  69.848  1.00 163.58 ? 92  ALA C O   1 
ATOM 6097  C CB  . ALA C 1 98  ? 8.183   31.691  71.906  1.00 151.03 ? 92  ALA C CB  1 
ATOM 6098  N N   . LYS C 1 99  ? 8.014   32.835  68.947  1.00 158.94 ? 93  LYS C N   1 
ATOM 6099  C CA  . LYS C 1 99  ? 7.611   33.905  68.005  1.00 161.35 ? 93  LYS C CA  1 
ATOM 6100  C C   . LYS C 1 99  ? 7.311   33.278  66.637  1.00 181.75 ? 93  LYS C C   1 
ATOM 6101  O O   . LYS C 1 99  ? 8.222   32.666  66.067  1.00 212.16 ? 93  LYS C O   1 
ATOM 6102  C CB  . LYS C 1 99  ? 8.772   34.887  67.823  1.00 145.01 ? 93  LYS C CB  1 
ATOM 6103  C CG  . LYS C 1 99  ? 10.123  34.382  68.293  1.00 120.01 ? 93  LYS C CG  1 
ATOM 6104  C CD  . LYS C 1 99  ? 11.266  35.213  67.726  1.00 103.13 ? 93  LYS C CD  1 
ATOM 6105  C CE  . LYS C 1 99  ? 12.071  34.448  66.733  1.00 95.98  ? 93  LYS C CE  1 
ATOM 6106  N NZ  . LYS C 1 99  ? 11.285  33.349  66.173  1.00 85.13  ? 93  LYS C NZ  1 
ATOM 6107  N N   . GLN C 1 100 ? 6.116   33.509  66.073  1.00 180.15 ? 94  GLN C N   1 
ATOM 6108  C CA  . GLN C 1 100 ? 5.869   33.029  64.682  1.00 169.23 ? 94  GLN C CA  1 
ATOM 6109  C C   . GLN C 1 100 ? 6.883   33.887  63.944  1.00 184.36 ? 94  GLN C C   1 
ATOM 6110  O O   . GLN C 1 100 ? 7.122   35.037  64.391  1.00 169.68 ? 94  GLN C O   1 
ATOM 6111  C CB  . GLN C 1 100 ? 4.439   33.146  64.149  1.00 160.79 ? 94  GLN C CB  1 
ATOM 6112  C CG  . GLN C 1 100 ? 4.213   34.304  63.184  1.00 158.07 ? 94  GLN C CG  1 
ATOM 6113  C CD  . GLN C 1 100 ? 3.181   35.292  63.679  1.00 160.38 ? 94  GLN C CD  1 
ATOM 6114  O OE1 . GLN C 1 100 ? 3.208   36.479  63.336  1.00 176.06 ? 94  GLN C OE1 1 
ATOM 6115  N NE2 . GLN C 1 100 ? 2.257   34.809  64.495  1.00 153.71 ? 94  GLN C NE2 1 
ATOM 6116  N N   . GLU C 1 101 ? 7.505   33.368  62.892  1.00 191.34 ? 95  GLU C N   1 
ATOM 6117  C CA  . GLU C 1 101 ? 8.646   34.179  62.413  1.00 161.84 ? 95  GLU C CA  1 
ATOM 6118  C C   . GLU C 1 101 ? 8.516   34.990  61.122  1.00 140.77 ? 95  GLU C C   1 
ATOM 6119  O O   . GLU C 1 101 ? 8.084   34.440  60.090  1.00 153.33 ? 95  GLU C O   1 
ATOM 6120  C CB  . GLU C 1 101 ? 9.663   33.047  62.224  1.00 155.48 ? 95  GLU C CB  1 
ATOM 6121  C CG  . GLU C 1 101 ? 9.005   31.703  61.925  1.00 146.20 ? 95  GLU C CG  1 
ATOM 6122  C CD  . GLU C 1 101 ? 8.548   31.534  60.485  1.00 139.14 ? 95  GLU C CD  1 
ATOM 6123  O OE1 . GLU C 1 101 ? 9.213   32.091  59.592  1.00 121.40 ? 95  GLU C OE1 1 
ATOM 6124  O OE2 . GLU C 1 101 ? 7.537   30.845  60.247  1.00 148.93 ? 95  GLU C OE2 1 
ATOM 6125  N N   . PRO C 1 102 ? 8.732   36.326  61.181  1.00 119.60 ? 96  PRO C N   1 
ATOM 6126  C CA  . PRO C 1 102 ? 8.951   37.114  59.986  1.00 108.17 ? 96  PRO C CA  1 
ATOM 6127  C C   . PRO C 1 102 ? 10.241  36.445  59.599  1.00 96.94  ? 96  PRO C C   1 
ATOM 6128  O O   . PRO C 1 102 ? 10.516  36.240  58.406  1.00 78.87  ? 96  PRO C O   1 
ATOM 6129  C CB  . PRO C 1 102 ? 9.163   38.489  60.539  1.00 106.61 ? 96  PRO C CB  1 
ATOM 6130  C CG  . PRO C 1 102 ? 8.348   38.491  61.807  1.00 108.23 ? 96  PRO C CG  1 
ATOM 6131  C CD  . PRO C 1 102 ? 8.636   37.123  62.388  1.00 107.45 ? 96  PRO C CD  1 
ATOM 6132  N N   . GLU C 1 103 ? 11.071  36.164  60.609  1.00 107.62 ? 97  GLU C N   1 
ATOM 6133  C CA  . GLU C 1 103 ? 12.382  35.505  60.400  1.00 105.26 ? 97  GLU C CA  1 
ATOM 6134  C C   . GLU C 1 103 ? 12.279  33.991  60.625  1.00 97.27  ? 97  GLU C C   1 
ATOM 6135  O O   . GLU C 1 103 ? 12.695  33.533  61.707  1.00 87.31  ? 97  GLU C O   1 
ATOM 6136  C CB  . GLU C 1 103 ? 13.329  36.081  61.443  1.00 116.31 ? 97  GLU C CB  1 
ATOM 6137  C CG  . GLU C 1 103 ? 12.728  37.236  62.240  1.00 115.38 ? 97  GLU C CG  1 
ATOM 6138  C CD  . GLU C 1 103 ? 11.783  36.846  63.365  1.00 118.23 ? 97  GLU C CD  1 
ATOM 6139  O OE1 . GLU C 1 103 ? 11.336  35.683  63.374  1.00 104.95 ? 97  GLU C OE1 1 
ATOM 6140  O OE2 . GLU C 1 103 ? 11.479  37.702  64.221  1.00 135.80 ? 97  GLU C OE2 1 
ATOM 6141  N N   . ASN C 1 105 ? 11.443  31.004  60.259  1.00 90.50  ? 99  ASN C N   1 
ATOM 6142  C CA  . ASN C 1 105 ? 11.428  29.887  59.278  1.00 88.83  ? 99  ASN C CA  1 
ATOM 6143  C C   . ASN C 1 105 ? 12.878  29.547  59.088  1.00 98.18  ? 99  ASN C C   1 
ATOM 6144  O O   . ASN C 1 105 ? 13.189  28.377  58.878  1.00 110.07 ? 99  ASN C O   1 
ATOM 6145  C CB  . ASN C 1 105 ? 10.933  30.234  57.878  1.00 77.32  ? 99  ASN C CB  1 
ATOM 6146  C CG  . ASN C 1 105 ? 9.696   29.474  57.477  1.00 69.98  ? 99  ASN C CG  1 
ATOM 6147  O OD1 . ASN C 1 105 ? 9.372   29.409  56.288  1.00 69.69  ? 99  ASN C OD1 1 
ATOM 6148  N ND2 . ASN C 1 105 ? 8.992   28.903  58.440  1.00 66.20  ? 99  ASN C ND2 1 
ATOM 6149  N N   . GLU C 1 106 ? 13.726  30.553  59.223  1.00 101.17 ? 100 GLU C N   1 
ATOM 6150  C CA  . GLU C 1 106 ? 15.108  30.141  58.970  1.00 106.86 ? 100 GLU C CA  1 
ATOM 6151  C C   . GLU C 1 106 ? 15.359  29.117  60.051  1.00 106.27 ? 100 GLU C C   1 
ATOM 6152  O O   . GLU C 1 106 ? 15.946  28.082  59.744  1.00 110.76 ? 100 GLU C O   1 
ATOM 6153  C CB  . GLU C 1 106 ? 16.075  31.302  59.160  1.00 107.89 ? 100 GLU C CB  1 
ATOM 6154  C CG  . GLU C 1 106 ? 15.701  32.563  58.387  1.00 105.72 ? 100 GLU C CG  1 
ATOM 6155  C CD  . GLU C 1 106 ? 16.696  33.698  58.558  1.00 101.72 ? 100 GLU C CD  1 
ATOM 6156  O OE1 . GLU C 1 106 ? 16.352  34.852  58.231  1.00 102.12 ? 100 GLU C OE1 1 
ATOM 6157  O OE2 . GLU C 1 106 ? 17.822  33.432  59.022  1.00 97.23  ? 100 GLU C OE2 1 
ATOM 6158  N N   . CYS C 1 107 ? 14.902  29.400  61.269  1.00 111.93 ? 101 CYS C N   1 
ATOM 6159  C CA  . CYS C 1 107 ? 15.019  28.354  62.307  1.00 122.84 ? 101 CYS C CA  1 
ATOM 6160  C C   . CYS C 1 107 ? 14.194  27.112  62.007  1.00 108.75 ? 101 CYS C C   1 
ATOM 6161  O O   . CYS C 1 107 ? 14.728  26.009  62.164  1.00 112.83 ? 101 CYS C O   1 
ATOM 6162  C CB  . CYS C 1 107 ? 14.348  28.777  63.601  1.00 136.03 ? 101 CYS C CB  1 
ATOM 6163  S SG  . CYS C 1 107 ? 13.483  27.406  64.407  1.00 145.11 ? 101 CYS C SG  1 
ATOM 6164  N N   . PHE C 1 108 ? 12.954  27.288  61.549  1.00 91.90  ? 102 PHE C N   1 
ATOM 6165  C CA  . PHE C 1 108 ? 12.171  26.045  61.375  1.00 85.09  ? 102 PHE C CA  1 
ATOM 6166  C C   . PHE C 1 108 ? 12.874  25.258  60.321  1.00 88.73  ? 102 PHE C C   1 
ATOM 6167  O O   . PHE C 1 108 ? 13.016  24.041  60.448  1.00 98.44  ? 102 PHE C O   1 
ATOM 6168  C CB  . PHE C 1 108 ? 10.746  26.426  60.993  1.00 83.26  ? 102 PHE C CB  1 
ATOM 6169  C CG  . PHE C 1 108 ? 9.783   26.687  62.140  1.00 83.67  ? 102 PHE C CG  1 
ATOM 6170  C CD1 . PHE C 1 108 ? 9.753   25.858  63.251  1.00 85.81  ? 102 PHE C CD1 1 
ATOM 6171  C CD2 . PHE C 1 108 ? 8.895   27.753  62.087  1.00 82.79  ? 102 PHE C CD2 1 
ATOM 6172  C CE1 . PHE C 1 108 ? 8.866   26.100  64.284  1.00 86.80  ? 102 PHE C CE1 1 
ATOM 6173  C CE2 . PHE C 1 108 ? 8.012   27.990  63.124  1.00 78.40  ? 102 PHE C CE2 1 
ATOM 6174  C CZ  . PHE C 1 108 ? 8.000   27.164  64.219  1.00 84.11  ? 102 PHE C CZ  1 
ATOM 6175  N N   . LEU C 1 109 ? 13.301  25.950  59.272  1.00 86.08  ? 103 LEU C N   1 
ATOM 6176  C CA  . LEU C 1 109 ? 14.106  25.319  58.201  1.00 85.13  ? 103 LEU C CA  1 
ATOM 6177  C C   . LEU C 1 109 ? 15.449  24.860  58.774  1.00 95.04  ? 103 LEU C C   1 
ATOM 6178  O O   . LEU C 1 109 ? 15.918  23.772  58.413  1.00 109.07 ? 103 LEU C O   1 
ATOM 6179  C CB  . LEU C 1 109 ? 14.209  26.275  57.018  1.00 80.01  ? 103 LEU C CB  1 
ATOM 6180  C CG  . LEU C 1 109 ? 12.889  26.571  56.308  1.00 73.93  ? 103 LEU C CG  1 
ATOM 6181  C CD1 . LEU C 1 109 ? 13.054  27.751  55.375  1.00 66.78  ? 103 LEU C CD1 1 
ATOM 6182  C CD2 . LEU C 1 109 ? 12.443  25.334  55.557  1.00 71.33  ? 103 LEU C CD2 1 
ATOM 6183  N N   . GLN C 1 110 ? 16.031  25.674  59.647  1.00 100.19 ? 104 GLN C N   1 
ATOM 6184  C CA  . GLN C 1 110 ? 17.379  25.365  60.183  1.00 107.53 ? 104 GLN C CA  1 
ATOM 6185  C C   . GLN C 1 110 ? 17.263  24.055  60.943  1.00 114.85 ? 104 GLN C C   1 
ATOM 6186  O O   . GLN C 1 110 ? 18.199  23.241  60.865  1.00 115.03 ? 104 GLN C O   1 
ATOM 6187  C CB  . GLN C 1 110 ? 17.944  26.408  61.143  1.00 103.23 ? 104 GLN C CB  1 
ATOM 6188  C CG  . GLN C 1 110 ? 19.404  26.753  60.887  1.00 99.04  ? 104 GLN C CG  1 
ATOM 6189  C CD  . GLN C 1 110 ? 19.616  27.408  59.543  1.00 100.38 ? 104 GLN C CD  1 
ATOM 6190  O OE1 . GLN C 1 110 ? 19.913  26.746  58.543  1.00 95.01  ? 104 GLN C OE1 1 
ATOM 6191  N NE2 . GLN C 1 110 ? 19.449  28.722  59.509  1.00 96.14  ? 104 GLN C NE2 1 
ATOM 6192  N N   . HIS C 1 111 ? 16.165  23.867  61.672  1.00 120.55 ? 105 HIS C N   1 
ATOM 6193  C CA  . HIS C 1 111 ? 16.141  22.564  62.358  1.00 110.67 ? 105 HIS C CA  1 
ATOM 6194  C C   . HIS C 1 111 ? 15.261  21.635  61.550  1.00 86.63  ? 105 HIS C C   1 
ATOM 6195  O O   . HIS C 1 111 ? 14.047  21.822  61.464  1.00 75.39  ? 105 HIS C O   1 
ATOM 6196  C CB  . HIS C 1 111 ? 15.517  22.731  63.742  1.00 111.57 ? 105 HIS C CB  1 
ATOM 6197  C CG  . HIS C 1 111 ? 16.159  23.786  64.577  1.00 111.15 ? 105 HIS C CG  1 
ATOM 6198  N ND1 . HIS C 1 111 ? 17.497  23.772  64.899  1.00 112.00 ? 105 HIS C ND1 1 
ATOM 6199  C CD2 . HIS C 1 111 ? 15.651  24.876  65.158  1.00 108.18 ? 105 HIS C CD2 1 
ATOM 6200  C CE1 . HIS C 1 111 ? 17.777  24.828  65.647  1.00 110.08 ? 105 HIS C CE1 1 
ATOM 6201  N NE2 . HIS C 1 111 ? 16.670  25.512  65.816  1.00 110.06 ? 105 HIS C NE2 1 
ATOM 6202  N N   . LYS C 1 112 ? 15.911  20.679  60.930  1.00 79.06  ? 106 LYS C N   1 
ATOM 6203  C CA  . LYS C 1 112 ? 15.204  19.633  60.183  1.00 81.65  ? 106 LYS C CA  1 
ATOM 6204  C C   . LYS C 1 112 ? 16.264  18.546  60.273  1.00 98.97  ? 106 LYS C C   1 
ATOM 6205  O O   . LYS C 1 112 ? 17.445  18.882  60.083  1.00 101.69 ? 106 LYS C O   1 
ATOM 6206  C CB  . LYS C 1 112 ? 14.882  20.134  58.780  1.00 80.37  ? 106 LYS C CB  1 
ATOM 6207  C CG  . LYS C 1 112 ? 13.420  20.378  58.451  1.00 87.76  ? 106 LYS C CG  1 
ATOM 6208  C CD  . LYS C 1 112 ? 13.292  21.180  57.163  1.00 91.47  ? 106 LYS C CD  1 
ATOM 6209  C CE  . LYS C 1 112 ? 11.972  21.027  56.489  1.00 91.71  ? 106 LYS C CE  1 
ATOM 6210  N NZ  . LYS C 1 112 ? 12.059  21.288  55.050  1.00 83.87  ? 106 LYS C NZ  1 
ATOM 6211  N N   . ASP C 1 113 ? 15.896  17.320  60.605  1.00 108.13 ? 107 ASP C N   1 
ATOM 6212  C CA  . ASP C 1 113 ? 16.962  16.318  60.855  1.00 126.97 ? 107 ASP C CA  1 
ATOM 6213  C C   . ASP C 1 113 ? 16.867  15.178  59.841  1.00 146.82 ? 107 ASP C C   1 
ATOM 6214  O O   . ASP C 1 113 ? 15.746  14.680  59.619  1.00 152.49 ? 107 ASP C O   1 
ATOM 6215  C CB  . ASP C 1 113 ? 16.926  15.884  62.311  1.00 130.28 ? 107 ASP C CB  1 
ATOM 6216  C CG  . ASP C 1 113 ? 18.250  15.990  63.052  1.00 126.40 ? 107 ASP C CG  1 
ATOM 6217  O OD1 . ASP C 1 113 ? 19.299  15.994  62.374  1.00 125.56 ? 107 ASP C OD1 1 
ATOM 6218  O OD2 . ASP C 1 113 ? 18.221  16.063  64.298  1.00 120.87 ? 107 ASP C OD2 1 
ATOM 6219  N N   . ASP C 1 114 ? 17.992  14.796  59.229  1.00 158.52 ? 108 ASP C N   1 
ATOM 6220  C CA  . ASP C 1 114 ? 17.936  13.617  58.330  1.00 165.28 ? 108 ASP C CA  1 
ATOM 6221  C C   . ASP C 1 114 ? 17.538  12.444  59.199  1.00 163.45 ? 108 ASP C C   1 
ATOM 6222  O O   . ASP C 1 114 ? 16.720  11.615  58.750  1.00 155.94 ? 108 ASP C O   1 
ATOM 6223  C CB  . ASP C 1 114 ? 19.292  13.246  57.774  1.00 169.25 ? 108 ASP C CB  1 
ATOM 6224  C CG  . ASP C 1 114 ? 19.871  11.921  58.254  1.00 171.35 ? 108 ASP C CG  1 
ATOM 6225  O OD1 . ASP C 1 114 ? 20.540  11.922  59.312  1.00 174.92 ? 108 ASP C OD1 1 
ATOM 6226  O OD2 . ASP C 1 114 ? 19.645  10.900  57.570  1.00 168.46 ? 108 ASP C OD2 1 
ATOM 6227  N N   . ASN C 1 115 ? 18.111  12.375  60.401  1.00 159.49 ? 109 ASN C N   1 
ATOM 6228  C CA  . ASN C 1 115 ? 17.576  11.350  61.319  1.00 149.08 ? 109 ASN C CA  1 
ATOM 6229  C C   . ASN C 1 115 ? 16.983  12.099  62.498  1.00 133.18 ? 109 ASN C C   1 
ATOM 6230  O O   . ASN C 1 115 ? 17.721  12.846  63.157  1.00 118.77 ? 109 ASN C O   1 
ATOM 6231  C CB  . ASN C 1 115 ? 18.658  10.385  61.785  1.00 139.28 ? 109 ASN C CB  1 
ATOM 6232  C CG  . ASN C 1 115 ? 18.237  8.942   61.650  1.00 129.34 ? 109 ASN C CG  1 
ATOM 6233  O OD1 . ASN C 1 115 ? 18.357  8.165   62.602  1.00 124.49 ? 109 ASN C OD1 1 
ATOM 6234  N ND2 . ASN C 1 115 ? 17.746  8.565   60.480  1.00 120.11 ? 109 ASN C ND2 1 
ATOM 6235  N N   . PRO C 1 116 ? 15.695  11.906  62.808  1.00 116.49 ? 110 PRO C N   1 
ATOM 6236  C CA  . PRO C 1 116 ? 15.115  12.418  64.026  1.00 107.57 ? 110 PRO C CA  1 
ATOM 6237  C C   . PRO C 1 116 ? 15.314  11.177  64.852  1.00 109.41 ? 110 PRO C C   1 
ATOM 6238  O O   . PRO C 1 116 ? 14.915  11.170  66.030  1.00 109.85 ? 110 PRO C O   1 
ATOM 6239  C CB  . PRO C 1 116 ? 13.687  12.680  63.619  1.00 107.98 ? 110 PRO C CB  1 
ATOM 6240  C CG  . PRO C 1 116 ? 13.693  12.528  62.112  1.00 112.45 ? 110 PRO C CG  1 
ATOM 6241  C CD  . PRO C 1 116 ? 14.694  11.417  61.884  1.00 109.76 ? 110 PRO C CD  1 
ATOM 6242  N N   . ASN C 1 117 ? 15.924  10.142  64.266  1.00 116.72 ? 111 ASN C N   1 
ATOM 6243  C CA  . ASN C 1 117 ? 16.021  8.818   64.931  1.00 119.81 ? 111 ASN C CA  1 
ATOM 6244  C C   . ASN C 1 117 ? 14.598  8.332   65.194  1.00 110.36 ? 111 ASN C C   1 
ATOM 6245  O O   . ASN C 1 117 ? 14.354  7.759   66.266  1.00 109.96 ? 111 ASN C O   1 
ATOM 6246  C CB  . ASN C 1 117 ? 16.931  8.857   66.152  1.00 129.52 ? 111 ASN C CB  1 
ATOM 6247  C CG  . ASN C 1 117 ? 18.390  8.789   65.766  1.00 130.68 ? 111 ASN C CG  1 
ATOM 6248  O OD1 . ASN C 1 117 ? 18.896  9.690   65.089  1.00 120.21 ? 111 ASN C OD1 1 
ATOM 6249  N ND2 . ASN C 1 117 ? 19.078  7.735   66.178  1.00 127.00 ? 111 ASN C ND2 1 
ATOM 6250  N N   . LEU C 1 118 ? 13.693  8.602   64.257  1.00 101.19 ? 112 LEU C N   1 
ATOM 6251  C CA  . LEU C 1 118 ? 12.294  8.105   64.345  1.00 102.42 ? 112 LEU C CA  1 
ATOM 6252  C C   . LEU C 1 118 ? 12.335  6.585   64.149  1.00 105.82 ? 112 LEU C C   1 
ATOM 6253  O O   . LEU C 1 118 ? 13.275  6.101   63.486  1.00 106.63 ? 112 LEU C O   1 
ATOM 6254  C CB  . LEU C 1 118 ? 11.364  8.804   63.356  1.00 97.43  ? 112 LEU C CB  1 
ATOM 6255  C CG  . LEU C 1 118 ? 11.139  10.294  63.605  1.00 87.18  ? 112 LEU C CG  1 
ATOM 6256  C CD1 . LEU C 1 118 ? 10.450  10.902  62.407  1.00 85.94  ? 112 LEU C CD1 1 
ATOM 6257  C CD2 . LEU C 1 118 ? 10.307  10.470  64.852  1.00 87.43  ? 112 LEU C CD2 1 
ATOM 6258  N N   . PRO C 1 119 ? 11.397  5.808   64.723  1.00 103.98 ? 113 PRO C N   1 
ATOM 6259  C CA  . PRO C 1 119 ? 11.505  4.356   64.683  1.00 99.99  ? 113 PRO C CA  1 
ATOM 6260  C C   . PRO C 1 119 ? 11.457  3.664   63.349  1.00 107.18 ? 113 PRO C C   1 
ATOM 6261  O O   . PRO C 1 119 ? 10.696  4.093   62.472  1.00 119.76 ? 113 PRO C O   1 
ATOM 6262  C CB  . PRO C 1 119 ? 10.235  4.014   65.455  1.00 95.05  ? 113 PRO C CB  1 
ATOM 6263  C CG  . PRO C 1 119 ? 9.289   5.143   65.159  1.00 94.82  ? 113 PRO C CG  1 
ATOM 6264  C CD  . PRO C 1 119 ? 10.212  6.310   65.388  1.00 100.03 ? 113 PRO C CD  1 
ATOM 6265  N N   . ARG C 1 120 ? 12.271  2.619   63.191  1.00 109.51 ? 114 ARG C N   1 
ATOM 6266  C CA  . ARG C 1 120 ? 12.221  1.807   61.955  1.00 109.76 ? 114 ARG C CA  1 
ATOM 6267  C C   . ARG C 1 120 ? 10.754  1.706   61.582  1.00 104.95 ? 114 ARG C C   1 
ATOM 6268  O O   . ARG C 1 120 ? 9.938   1.417   62.476  1.00 112.36 ? 114 ARG C O   1 
ATOM 6269  C CB  . ARG C 1 120 ? 12.780  0.404   62.201  1.00 114.14 ? 114 ARG C CB  1 
ATOM 6270  C CG  . ARG C 1 120 ? 12.773  -0.108  63.634  1.00 110.07 ? 114 ARG C CG  1 
ATOM 6271  C CD  . ARG C 1 120 ? 12.701  -1.629  63.677  1.00 114.95 ? 114 ARG C CD  1 
ATOM 6272  N NE  . ARG C 1 120 ? 14.013  -2.279  63.774  1.00 125.87 ? 114 ARG C NE  1 
ATOM 6273  C CZ  . ARG C 1 120 ? 14.243  -3.457  64.350  1.00 118.81 ? 114 ARG C CZ  1 
ATOM 6274  N NH1 . ARG C 1 120 ? 13.319  -4.400  64.324  1.00 112.55 ? 114 ARG C NH1 1 
ATOM 6275  N NH2 . ARG C 1 120 ? 15.397  -3.690  64.951  1.00 106.69 ? 114 ARG C NH2 1 
ATOM 6276  N N   . LEU C 1 121 ? 10.428  1.897   60.311  1.00 91.38  ? 115 LEU C N   1 
ATOM 6277  C CA  . LEU C 1 121 ? 8.996   1.945   60.035  1.00 84.21  ? 115 LEU C CA  1 
ATOM 6278  C C   . LEU C 1 121 ? 8.521   0.534   59.701  1.00 77.50  ? 115 LEU C C   1 
ATOM 6279  O O   . LEU C 1 121 ? 8.606   0.115   58.558  1.00 89.39  ? 115 LEU C O   1 
ATOM 6280  C CB  . LEU C 1 121 ? 8.626   2.913   58.908  1.00 82.78  ? 115 LEU C CB  1 
ATOM 6281  C CG  . LEU C 1 121 ? 7.170   3.409   58.874  1.00 84.31  ? 115 LEU C CG  1 
ATOM 6282  C CD1 . LEU C 1 121 ? 6.642   3.528   57.451  1.00 80.68  ? 115 LEU C CD1 1 
ATOM 6283  C CD2 . LEU C 1 121 ? 6.186   2.575   59.690  1.00 89.04  ? 115 LEU C CD2 1 
ATOM 6284  N N   . VAL C 1 122 ? 8.006   -0.192  60.694  1.00 75.84  ? 116 VAL C N   1 
ATOM 6285  C CA  . VAL C 1 122 ? 7.623   -1.582  60.498  1.00 76.99  ? 116 VAL C CA  1 
ATOM 6286  C C   . VAL C 1 122 ? 6.192   -1.616  59.974  1.00 82.78  ? 116 VAL C C   1 
ATOM 6287  O O   . VAL C 1 122 ? 5.316   -0.980  60.552  1.00 92.45  ? 116 VAL C O   1 
ATOM 6288  C CB  . VAL C 1 122 ? 7.762   -2.450  61.764  1.00 77.09  ? 116 VAL C CB  1 
ATOM 6289  C CG1 . VAL C 1 122 ? 7.375   -1.708  63.041  1.00 79.67  ? 116 VAL C CG1 1 
ATOM 6290  C CG2 . VAL C 1 122 ? 6.974   -3.750  61.632  1.00 76.73  ? 116 VAL C CG2 1 
ATOM 6291  N N   . ARG C 1 123 ? 5.962   -2.378  58.894  1.00 84.79  ? 117 ARG C N   1 
ATOM 6292  C CA  . ARG C 1 123 ? 4.665   -2.394  58.228  1.00 80.76  ? 117 ARG C CA  1 
ATOM 6293  C C   . ARG C 1 123 ? 3.836   -3.508  58.858  1.00 67.71  ? 117 ARG C C   1 
ATOM 6294  O O   . ARG C 1 123 ? 4.403   -4.520  59.244  1.00 66.95  ? 117 ARG C O   1 
ATOM 6295  C CB  . ARG C 1 123 ? 4.773   -2.479  56.693  1.00 83.54  ? 117 ARG C CB  1 
ATOM 6296  C CG  . ARG C 1 123 ? 5.533   -3.659  56.096  1.00 95.63  ? 117 ARG C CG  1 
ATOM 6297  C CD  . ARG C 1 123 ? 5.862   -3.571  54.584  1.00 97.99  ? 117 ARG C CD  1 
ATOM 6298  N NE  . ARG C 1 123 ? 6.900   -2.597  54.203  1.00 96.07  ? 117 ARG C NE  1 
ATOM 6299  C CZ  . ARG C 1 123 ? 7.417   -2.412  52.979  1.00 87.61  ? 117 ARG C CZ  1 
ATOM 6300  N NH1 . ARG C 1 123 ? 7.148   -3.250  52.002  1.00 87.15  ? 117 ARG C NH1 1 
ATOM 6301  N NH2 . ARG C 1 123 ? 8.225   -1.398  52.724  1.00 85.73  ? 117 ARG C NH2 1 
ATOM 6302  N N   . PRO C 1 124 ? 2.500   -3.336  59.026  1.00 61.35  ? 118 PRO C N   1 
ATOM 6303  C CA  . PRO C 1 124 ? 1.615   -4.425  59.459  1.00 59.44  ? 118 PRO C CA  1 
ATOM 6304  C C   . PRO C 1 124 ? 1.529   -5.575  58.464  1.00 57.82  ? 118 PRO C C   1 
ATOM 6305  O O   . PRO C 1 124 ? 2.072   -5.491  57.374  1.00 60.85  ? 118 PRO C O   1 
ATOM 6306  C CB  . PRO C 1 124 ? 0.249   -3.759  59.621  1.00 59.70  ? 118 PRO C CB  1 
ATOM 6307  C CG  . PRO C 1 124 ? 0.561   -2.287  59.708  1.00 61.11  ? 118 PRO C CG  1 
ATOM 6308  C CD  . PRO C 1 124 ? 1.772   -2.075  58.826  1.00 57.58  ? 118 PRO C CD  1 
ATOM 6309  N N   . GLU C 1 125 ? 0.847   -6.653  58.852  1.00 65.60  ? 119 GLU C N   1 
ATOM 6310  C CA  . GLU C 1 125 ? 0.676   -7.805  57.979  1.00 70.35  ? 119 GLU C CA  1 
ATOM 6311  C C   . GLU C 1 125 ? -0.132  -7.370  56.761  1.00 69.52  ? 119 GLU C C   1 
ATOM 6312  O O   . GLU C 1 125 ? -0.808  -6.338  56.804  1.00 69.01  ? 119 GLU C O   1 
ATOM 6313  C CB  . GLU C 1 125 ? -0.033  -8.956  58.697  1.00 74.39  ? 119 GLU C CB  1 
ATOM 6314  C CG  . GLU C 1 125 ? 0.857   -9.691  59.692  1.00 75.73  ? 119 GLU C CG  1 
ATOM 6315  C CD  . GLU C 1 125 ? 1.893   -10.565 59.009  1.00 79.72  ? 119 GLU C CD  1 
ATOM 6316  O OE1 . GLU C 1 125 ? 1.479   -11.580 58.400  1.00 74.04  ? 119 GLU C OE1 1 
ATOM 6317  O OE2 . GLU C 1 125 ? 3.100   -10.232 59.082  1.00 81.67  ? 119 GLU C OE2 1 
ATOM 6318  N N   . VAL C 1 126 ? -0.057  -8.168  55.689  1.00 60.50  ? 120 VAL C N   1 
ATOM 6319  C CA  . VAL C 1 126 ? -0.673  -7.786  54.432  1.00 59.61  ? 120 VAL C CA  1 
ATOM 6320  C C   . VAL C 1 126 ? -2.183  -7.726  54.628  1.00 57.40  ? 120 VAL C C   1 
ATOM 6321  O O   . VAL C 1 126 ? -2.822  -6.737  54.285  1.00 62.52  ? 120 VAL C O   1 
ATOM 6322  C CB  . VAL C 1 126 ? -0.301  -8.730  53.277  1.00 64.51  ? 120 VAL C CB  1 
ATOM 6323  C CG1 . VAL C 1 126 ? -0.998  -8.320  51.987  1.00 64.30  ? 120 VAL C CG1 1 
ATOM 6324  C CG2 . VAL C 1 126 ? 1.209   -8.807  53.067  1.00 66.58  ? 120 VAL C CG2 1 
ATOM 6325  N N   . ASP C 1 127 ? -2.742  -8.788  55.200  1.00 57.94  ? 121 ASP C N   1 
ATOM 6326  C CA  . ASP C 1 127 ? -4.155  -8.815  55.531  1.00 64.12  ? 121 ASP C CA  1 
ATOM 6327  C C   . ASP C 1 127 ? -4.529  -7.527  56.260  1.00 65.34  ? 121 ASP C C   1 
ATOM 6328  O O   . ASP C 1 127 ? -5.503  -6.867  55.894  1.00 67.77  ? 121 ASP C O   1 
ATOM 6329  C CB  . ASP C 1 127 ? -4.503  -10.048 56.353  1.00 68.36  ? 121 ASP C CB  1 
ATOM 6330  C CG  . ASP C 1 127 ? -4.213  -11.374 55.665  1.00 74.71  ? 121 ASP C CG  1 
ATOM 6331  O OD1 . ASP C 1 127 ? -3.017  -11.673 55.452  1.00 79.43  ? 121 ASP C OD1 1 
ATOM 6332  O OD2 . ASP C 1 127 ? -5.181  -12.085 55.325  1.00 79.83  ? 121 ASP C OD2 1 
ATOM 6333  N N   . VAL C 1 128 ? -3.723  -7.177  57.271  1.00 61.54  ? 122 VAL C N   1 
ATOM 6334  C CA  . VAL C 1 128 ? -4.024  -6.065  58.158  1.00 62.42  ? 122 VAL C CA  1 
ATOM 6335  C C   . VAL C 1 128 ? -4.085  -4.771  57.349  1.00 62.41  ? 122 VAL C C   1 
ATOM 6336  O O   . VAL C 1 128 ? -5.071  -4.034  57.441  1.00 65.12  ? 122 VAL C O   1 
ATOM 6337  C CB  . VAL C 1 128 ? -3.017  -5.954  59.323  1.00 65.66  ? 122 VAL C CB  1 
ATOM 6338  C CG1 . VAL C 1 128 ? -3.329  -4.775  60.243  1.00 66.72  ? 122 VAL C CG1 1 
ATOM 6339  C CG2 . VAL C 1 128 ? -2.945  -7.237  60.143  1.00 62.84  ? 122 VAL C CG2 1 
ATOM 6340  N N   . MET C 1 129 ? -3.019  -4.499  56.579  1.00 61.94  ? 123 MET C N   1 
ATOM 6341  C CA  . MET C 1 129 ? -2.908  -3.259  55.826  1.00 58.77  ? 123 MET C CA  1 
ATOM 6342  C C   . MET C 1 129 ? -4.116  -3.130  54.914  1.00 59.52  ? 123 MET C C   1 
ATOM 6343  O O   . MET C 1 129 ? -4.815  -2.120  54.941  1.00 62.85  ? 123 MET C O   1 
ATOM 6344  C CB  . MET C 1 129 ? -1.618  -3.204  55.007  1.00 57.99  ? 123 MET C CB  1 
ATOM 6345  C CG  . MET C 1 129 ? -0.412  -2.777  55.829  1.00 63.81  ? 123 MET C CG  1 
ATOM 6346  S SD  . MET C 1 129 ? 1.160   -2.720  54.935  1.00 71.72  ? 123 MET C SD  1 
ATOM 6347  C CE  . MET C 1 129 ? 1.283   -4.367  54.226  1.00 75.63  ? 123 MET C CE  1 
ATOM 6348  N N   . CYS C 1 130 ? -4.386  -4.197  54.164  1.00 60.88  ? 124 CYS C N   1 
ATOM 6349  C CA  . CYS C 1 130 ? -5.529  -4.236  53.265  1.00 68.64  ? 124 CYS C CA  1 
ATOM 6350  C C   . CYS C 1 130 ? -6.825  -3.830  53.960  1.00 63.60  ? 124 CYS C C   1 
ATOM 6351  O O   . CYS C 1 130 ? -7.621  -3.082  53.400  1.00 63.38  ? 124 CYS C O   1 
ATOM 6352  C CB  . CYS C 1 130 ? -5.660  -5.622  52.664  1.00 71.03  ? 124 CYS C CB  1 
ATOM 6353  S SG  . CYS C 1 130 ? -4.148  -6.058  51.777  1.00 72.47  ? 124 CYS C SG  1 
ATOM 6354  N N   . THR C 1 131 ? -7.046  -4.339  55.167  1.00 57.72  ? 125 THR C N   1 
ATOM 6355  C CA  . THR C 1 131 ? -8.255  -3.984  55.876  1.00 58.94  ? 125 THR C CA  1 
ATOM 6356  C C   . THR C 1 131 ? -8.215  -2.477  56.115  1.00 60.07  ? 125 THR C C   1 
ATOM 6357  O O   . THR C 1 131 ? -9.114  -1.758  55.687  1.00 66.56  ? 125 THR C O   1 
ATOM 6358  C CB  . THR C 1 131 ? -8.371  -4.830  57.143  1.00 58.56  ? 125 THR C CB  1 
ATOM 6359  O OG1 . THR C 1 131 ? -8.299  -6.171  56.663  1.00 51.91  ? 125 THR C OG1 1 
ATOM 6360  C CG2 . THR C 1 131 ? -9.693  -4.638  57.861  1.00 61.17  ? 125 THR C CG2 1 
ATOM 6361  N N   . ALA C 1 132 ? -7.117  -1.996  56.703  1.00 61.23  ? 126 ALA C N   1 
ATOM 6362  C CA  . ALA C 1 132 ? -7.007  -0.604  57.124  1.00 62.55  ? 126 ALA C CA  1 
ATOM 6363  C C   . ALA C 1 132 ? -7.230  0.356   55.960  1.00 56.44  ? 126 ALA C C   1 
ATOM 6364  O O   . ALA C 1 132 ? -7.749  1.444   56.161  1.00 52.61  ? 126 ALA C O   1 
ATOM 6365  C CB  . ALA C 1 132 ? -5.655  -0.360  57.749  1.00 63.61  ? 126 ALA C CB  1 
ATOM 6366  N N   . PHE C 1 133 ? -6.783  -0.055  54.773  1.00 57.09  ? 127 PHE C N   1 
ATOM 6367  C CA  . PHE C 1 133 ? -6.943  0.717   53.557  1.00 63.28  ? 127 PHE C CA  1 
ATOM 6368  C C   . PHE C 1 133 ? -8.396  0.681   53.090  1.00 73.35  ? 127 PHE C C   1 
ATOM 6369  O O   . PHE C 1 133 ? -8.892  1.668   52.555  1.00 84.25  ? 127 PHE C O   1 
ATOM 6370  C CB  . PHE C 1 133 ? -6.002  0.133   52.499  1.00 64.97  ? 127 PHE C CB  1 
ATOM 6371  C CG  . PHE C 1 133 ? -6.245  0.669   51.098  1.00 63.74  ? 127 PHE C CG  1 
ATOM 6372  C CD1 . PHE C 1 133 ? -5.766  1.919   50.736  1.00 66.59  ? 127 PHE C CD1 1 
ATOM 6373  C CD2 . PHE C 1 133 ? -6.961  -0.072  50.166  1.00 60.35  ? 127 PHE C CD2 1 
ATOM 6374  C CE1 . PHE C 1 133 ? -5.991  2.412   49.467  1.00 77.13  ? 127 PHE C CE1 1 
ATOM 6375  C CE2 . PHE C 1 133 ? -7.185  0.424   48.896  1.00 68.35  ? 127 PHE C CE2 1 
ATOM 6376  C CZ  . PHE C 1 133 ? -6.701  1.664   48.548  1.00 78.59  ? 127 PHE C CZ  1 
ATOM 6377  N N   . HIS C 1 134 ? -9.026  -0.460  53.273  1.00 78.40  ? 128 HIS C N   1 
ATOM 6378  C CA  . HIS C 1 134 ? -10.403 -0.500  52.766  1.00 84.13  ? 128 HIS C CA  1 
ATOM 6379  C C   . HIS C 1 134 ? -11.205 0.316   53.769  1.00 86.73  ? 128 HIS C C   1 
ATOM 6380  O O   . HIS C 1 134 ? -12.018 1.148   53.352  1.00 95.05  ? 128 HIS C O   1 
ATOM 6381  C CB  . HIS C 1 134 ? -10.855 -1.946  52.553  1.00 84.24  ? 128 HIS C CB  1 
ATOM 6382  C CG  . HIS C 1 134 ? -10.405 -2.498  51.250  1.00 86.58  ? 128 HIS C CG  1 
ATOM 6383  N ND1 . HIS C 1 134 ? -10.942 -2.082  50.053  1.00 95.56  ? 128 HIS C ND1 1 
ATOM 6384  C CD2 . HIS C 1 134 ? -9.473  -3.400  50.946  1.00 94.23  ? 128 HIS C CD2 1 
ATOM 6385  C CE1 . HIS C 1 134 ? -10.351 -2.730  49.064  1.00 101.42 ? 128 HIS C CE1 1 
ATOM 6386  N NE2 . HIS C 1 134 ? -9.456  -3.536  49.584  1.00 103.37 ? 128 HIS C NE2 1 
ATOM 6387  N N   . ASP C 1 135 ? -11.034 0.023   55.051  1.00 80.44  ? 129 ASP C N   1 
ATOM 6388  C CA  . ASP C 1 135 ? -11.911 0.720   56.020  1.00 90.86  ? 129 ASP C CA  1 
ATOM 6389  C C   . ASP C 1 135 ? -11.786 2.248   56.136  1.00 91.79  ? 129 ASP C C   1 
ATOM 6390  O O   . ASP C 1 135 ? -12.857 2.867   56.224  1.00 91.10  ? 129 ASP C O   1 
ATOM 6391  C CB  . ASP C 1 135 ? -11.688 0.111   57.391  1.00 103.45 ? 129 ASP C CB  1 
ATOM 6392  C CG  . ASP C 1 135 ? -11.766 -1.408  57.453  1.00 114.61 ? 129 ASP C CG  1 
ATOM 6393  O OD1 . ASP C 1 135 ? -11.894 -2.035  56.381  1.00 123.16 ? 129 ASP C OD1 1 
ATOM 6394  O OD2 . ASP C 1 135 ? -11.698 -1.951  58.573  1.00 111.80 ? 129 ASP C OD2 1 
ATOM 6395  N N   . ASN C 1 136 ? -10.594 2.866   56.171  1.00 93.43  ? 130 ASN C N   1 
ATOM 6396  C CA  . ASN C 1 136 ? -10.558 4.361   56.190  1.00 85.92  ? 130 ASN C CA  1 
ATOM 6397  C C   . ASN C 1 136 ? -10.184 4.980   54.857  1.00 76.00  ? 130 ASN C C   1 
ATOM 6398  O O   . ASN C 1 136 ? -10.814 5.971   54.467  1.00 83.79  ? 130 ASN C O   1 
ATOM 6399  C CB  . ASN C 1 136 ? -9.511  4.864   57.163  1.00 92.64  ? 130 ASN C CB  1 
ATOM 6400  C CG  . ASN C 1 136 ? -10.018 4.867   58.585  1.00 108.26 ? 130 ASN C CG  1 
ATOM 6401  O OD1 . ASN C 1 136 ? -10.661 5.831   59.013  1.00 105.38 ? 130 ASN C OD1 1 
ATOM 6402  N ND2 . ASN C 1 136 ? -9.744  3.804   59.327  1.00 117.42 ? 130 ASN C ND2 1 
ATOM 6403  N N   . GLU C 1 137 ? -9.132  4.474   54.255  1.00 72.05  ? 131 GLU C N   1 
ATOM 6404  C CA  . GLU C 1 137 ? -8.656  4.871   52.912  1.00 77.02  ? 131 GLU C CA  1 
ATOM 6405  C C   . GLU C 1 137 ? -8.047  6.276   52.879  1.00 75.39  ? 131 GLU C C   1 
ATOM 6406  O O   . GLU C 1 137 ? -6.841  6.373   52.644  1.00 64.08  ? 131 GLU C O   1 
ATOM 6407  C CB  . GLU C 1 137 ? -9.807  4.824   51.915  1.00 83.92  ? 131 GLU C CB  1 
ATOM 6408  C CG  . GLU C 1 137 ? -9.476  5.510   50.595  1.00 100.10 ? 131 GLU C CG  1 
ATOM 6409  C CD  . GLU C 1 137 ? -9.196  4.508   49.497  1.00 110.87 ? 131 GLU C CD  1 
ATOM 6410  O OE1 . GLU C 1 137 ? -9.727  3.382   49.585  1.00 120.40 ? 131 GLU C OE1 1 
ATOM 6411  O OE2 . GLU C 1 137 ? -8.448  4.854   48.563  1.00 112.93 ? 131 GLU C OE2 1 
ATOM 6412  N N   . GLU C 1 138 ? -8.818  7.312   53.205  1.00 82.08  ? 132 GLU C N   1 
ATOM 6413  C CA  . GLU C 1 138 ? -8.211  8.662   53.257  1.00 81.75  ? 132 GLU C CA  1 
ATOM 6414  C C   . GLU C 1 138 ? -7.154  8.778   54.347  1.00 74.71  ? 132 GLU C C   1 
ATOM 6415  O O   . GLU C 1 138 ? -6.081  9.326   54.070  1.00 57.28  ? 132 GLU C O   1 
ATOM 6416  C CB  . GLU C 1 138 ? -9.345  9.630   53.568  1.00 94.76  ? 132 GLU C CB  1 
ATOM 6417  C CG  . GLU C 1 138 ? -8.922  11.094  53.537  1.00 104.05 ? 132 GLU C CG  1 
ATOM 6418  C CD  . GLU C 1 138 ? -9.750  11.919  52.572  1.00 109.22 ? 132 GLU C CD  1 
ATOM 6419  O OE1 . GLU C 1 138 ? -10.384 11.316  51.682  1.00 102.08 ? 132 GLU C OE1 1 
ATOM 6420  O OE2 . GLU C 1 138 ? -9.764  13.159  52.709  1.00 117.98 ? 132 GLU C OE2 1 
ATOM 6421  N N   . THR C 1 139 ? -7.454  8.232   55.523  1.00 67.21  ? 133 THR C N   1 
ATOM 6422  C CA  . THR C 1 139 ? -6.523  8.280   56.662  1.00 65.25  ? 133 THR C CA  1 
ATOM 6423  C C   . THR C 1 139 ? -5.278  7.504   56.333  1.00 59.11  ? 133 THR C C   1 
ATOM 6424  O O   . THR C 1 139 ? -4.194  7.911   56.768  1.00 48.84  ? 133 THR C O   1 
ATOM 6425  C CB  . THR C 1 139 ? -7.222  7.858   57.950  1.00 67.15  ? 133 THR C CB  1 
ATOM 6426  O OG1 . THR C 1 139 ? -7.081  6.445   57.999  1.00 65.48  ? 133 THR C OG1 1 
ATOM 6427  C CG2 . THR C 1 139 ? -8.681  8.271   57.967  1.00 73.10  ? 133 THR C CG2 1 
ATOM 6428  N N   . PHE C 1 140 ? -5.444  6.364   55.670  1.00 59.24  ? 134 PHE C N   1 
ATOM 6429  C CA  . PHE C 1 140 ? -4.271  5.501   55.426  1.00 58.73  ? 134 PHE C CA  1 
ATOM 6430  C C   . PHE C 1 140 ? -3.267  6.202   54.569  1.00 60.34  ? 134 PHE C C   1 
ATOM 6431  O O   . PHE C 1 140 ? -2.059  6.101   54.850  1.00 52.39  ? 134 PHE C O   1 
ATOM 6432  C CB  . PHE C 1 140 ? -4.918  4.352   54.657  1.00 54.94  ? 134 PHE C CB  1 
ATOM 6433  C CG  . PHE C 1 140 ? -4.029  3.132   54.498  1.00 51.44  ? 134 PHE C CG  1 
ATOM 6434  C CD1 . PHE C 1 140 ? -3.891  2.218   55.531  1.00 50.14  ? 134 PHE C CD1 1 
ATOM 6435  C CD2 . PHE C 1 140 ? -3.329  2.913   53.323  1.00 54.09  ? 134 PHE C CD2 1 
ATOM 6436  C CE1 . PHE C 1 140 ? -3.075  1.114   55.390  1.00 51.54  ? 134 PHE C CE1 1 
ATOM 6437  C CE2 . PHE C 1 140 ? -2.514  1.809   53.192  1.00 52.74  ? 134 PHE C CE2 1 
ATOM 6438  C CZ  . PHE C 1 140 ? -2.389  0.914   54.223  1.00 51.79  ? 134 PHE C CZ  1 
ATOM 6439  N N   . LEU C 1 141 ? -3.741  6.892   53.540  1.00 60.59  ? 135 LEU C N   1 
ATOM 6440  C CA  . LEU C 1 141 ? -2.861  7.686   52.653  1.00 57.62  ? 135 LEU C CA  1 
ATOM 6441  C C   . LEU C 1 141 ? -2.206  8.830   53.427  1.00 54.57  ? 135 LEU C C   1 
ATOM 6442  O O   . LEU C 1 141 ? -1.026  9.104   53.203  1.00 45.22  ? 135 LEU C O   1 
ATOM 6443  C CB  . LEU C 1 141 ? -3.725  8.118   51.477  1.00 64.16  ? 135 LEU C CB  1 
ATOM 6444  C CG  . LEU C 1 141 ? -4.413  6.980   50.718  1.00 65.63  ? 135 LEU C CG  1 
ATOM 6445  C CD1 . LEU C 1 141 ? -5.218  7.491   49.545  1.00 60.79  ? 135 LEU C CD1 1 
ATOM 6446  C CD2 . LEU C 1 141 ? -3.420  5.932   50.264  1.00 67.51  ? 135 LEU C CD2 1 
ATOM 6447  N N   . LYS C 1 142 ? -2.967  9.465   54.304  1.00 56.62  ? 136 LYS C N   1 
ATOM 6448  C CA  . LYS C 1 142 ? -2.457  10.597  55.100  1.00 60.00  ? 136 LYS C CA  1 
ATOM 6449  C C   . LYS C 1 142 ? -1.317  10.114  55.992  1.00 60.63  ? 136 LYS C C   1 
ATOM 6450  O O   . LYS C 1 142 ? -0.331  10.848  56.123  1.00 54.33  ? 136 LYS C O   1 
ATOM 6451  C CB  . LYS C 1 142 ? -3.610  11.104  55.964  1.00 67.64  ? 136 LYS C CB  1 
ATOM 6452  C CG  . LYS C 1 142 ? -4.666  11.965  55.297  1.00 73.31  ? 136 LYS C CG  1 
ATOM 6453  C CD  . LYS C 1 142 ? -5.343  12.881  56.310  1.00 77.71  ? 136 LYS C CD  1 
ATOM 6454  C CE  . LYS C 1 142 ? -6.833  12.929  56.194  1.00 73.89  ? 136 LYS C CE  1 
ATOM 6455  N NZ  . LYS C 1 142 ? -7.428  13.732  57.266  1.00 71.27  ? 136 LYS C NZ  1 
ATOM 6456  N N   . LYS C 1 143 ? -1.451  8.925   56.571  1.00 60.19  ? 137 LYS C N   1 
ATOM 6457  C CA  . LYS C 1 143 ? -0.388  8.361   57.431  1.00 56.36  ? 137 LYS C CA  1 
ATOM 6458  C C   . LYS C 1 143 ? 0.834   8.182   56.541  1.00 55.43  ? 137 LYS C C   1 
ATOM 6459  O O   . LYS C 1 143 ? 1.941   8.446   57.005  1.00 50.48  ? 137 LYS C O   1 
ATOM 6460  C CB  . LYS C 1 143 ? -0.880  7.073   58.082  1.00 57.75  ? 137 LYS C CB  1 
ATOM 6461  C CG  . LYS C 1 143 ? -0.089  6.626   59.295  1.00 65.23  ? 137 LYS C CG  1 
ATOM 6462  C CD  . LYS C 1 143 ? -0.799  6.929   60.606  1.00 74.57  ? 137 LYS C CD  1 
ATOM 6463  C CE  . LYS C 1 143 ? -2.045  6.125   60.768  1.00 81.28  ? 137 LYS C CE  1 
ATOM 6464  N NZ  . LYS C 1 143 ? -1.896  5.126   61.828  1.00 85.35  ? 137 LYS C NZ  1 
ATOM 6465  N N   . TYR C 1 144 ? 0.633   7.737   55.309  1.00 60.41  ? 138 TYR C N   1 
ATOM 6466  C CA  . TYR C 1 144 ? 1.767   7.664   54.361  1.00 59.59  ? 138 TYR C CA  1 
ATOM 6467  C C   . TYR C 1 144 ? 2.361   9.044   54.296  1.00 58.60  ? 138 TYR C C   1 
ATOM 6468  O O   . TYR C 1 144 ? 3.497   9.231   54.742  1.00 60.97  ? 138 TYR C O   1 
ATOM 6469  C CB  . TYR C 1 144 ? 1.279   7.182   52.997  1.00 65.35  ? 138 TYR C CB  1 
ATOM 6470  C CG  . TYR C 1 144 ? 2.375   6.934   51.973  1.00 77.35  ? 138 TYR C CG  1 
ATOM 6471  C CD1 . TYR C 1 144 ? 3.067   5.733   51.942  1.00 99.03  ? 138 TYR C CD1 1 
ATOM 6472  C CD2 . TYR C 1 144 ? 2.718   7.904   51.043  1.00 73.19  ? 138 TYR C CD2 1 
ATOM 6473  C CE1 . TYR C 1 144 ? 4.068   5.505   51.014  1.00 112.99 ? 138 TYR C CE1 1 
ATOM 6474  C CE2 . TYR C 1 144 ? 3.718   7.690   50.112  1.00 86.93  ? 138 TYR C CE2 1 
ATOM 6475  C CZ  . TYR C 1 144 ? 4.394   6.486   50.098  1.00 117.37 ? 138 TYR C CZ  1 
ATOM 6476  O OH  . TYR C 1 144 ? 5.381   6.276   49.182  1.00 159.19 ? 138 TYR C OH  1 
ATOM 6477  N N   . LEU C 1 145 ? 1.611   10.000  53.755  1.00 54.54  ? 139 LEU C N   1 
ATOM 6478  C CA  . LEU C 1 145 ? 2.178   11.331  53.627  1.00 49.28  ? 139 LEU C CA  1 
ATOM 6479  C C   . LEU C 1 145 ? 2.883   11.682  54.935  1.00 49.16  ? 139 LEU C C   1 
ATOM 6480  O O   . LEU C 1 145 ? 4.036   12.100  54.925  1.00 42.98  ? 139 LEU C O   1 
ATOM 6481  C CB  . LEU C 1 145 ? 1.074   12.339  53.296  1.00 47.59  ? 139 LEU C CB  1 
ATOM 6482  C CG  . LEU C 1 145 ? 0.332   12.137  51.968  1.00 47.22  ? 139 LEU C CG  1 
ATOM 6483  C CD1 . LEU C 1 145 ? -0.969  12.945  51.813  1.00 46.10  ? 139 LEU C CD1 1 
ATOM 6484  C CD2 . LEU C 1 145 ? 1.294   12.484  50.863  1.00 49.22  ? 139 LEU C CD2 1 
ATOM 6485  N N   . TYR C 1 146 ? 2.188   11.456  56.060  1.00 51.30  ? 140 TYR C N   1 
ATOM 6486  C CA  . TYR C 1 146 ? 2.718   11.801  57.369  1.00 52.36  ? 140 TYR C CA  1 
ATOM 6487  C C   . TYR C 1 146 ? 4.052   11.096  57.622  1.00 50.53  ? 140 TYR C C   1 
ATOM 6488  O O   . TYR C 1 146 ? 5.002   11.743  58.033  1.00 49.11  ? 140 TYR C O   1 
ATOM 6489  C CB  . TYR C 1 146 ? 1.716   11.516  58.493  1.00 51.61  ? 140 TYR C CB  1 
ATOM 6490  C CG  . TYR C 1 146 ? 2.326   11.478  59.895  1.00 48.43  ? 140 TYR C CG  1 
ATOM 6491  C CD1 . TYR C 1 146 ? 2.792   12.629  60.515  1.00 44.71  ? 140 TYR C CD1 1 
ATOM 6492  C CD2 . TYR C 1 146 ? 2.417   10.284  60.608  1.00 46.46  ? 140 TYR C CD2 1 
ATOM 6493  C CE1 . TYR C 1 146 ? 3.320   12.590  61.794  1.00 44.49  ? 140 TYR C CE1 1 
ATOM 6494  C CE2 . TYR C 1 146 ? 2.959   10.229  61.879  1.00 42.03  ? 140 TYR C CE2 1 
ATOM 6495  C CZ  . TYR C 1 146 ? 3.397   11.388  62.477  1.00 42.38  ? 140 TYR C CZ  1 
ATOM 6496  O OH  . TYR C 1 146 ? 3.897   11.287  63.736  1.00 39.42  ? 140 TYR C OH  1 
ATOM 6497  N N   . GLU C 1 147 ? 4.121   9.775   57.426  1.00 52.07  ? 141 GLU C N   1 
ATOM 6498  C CA  . GLU C 1 147 ? 5.286   9.026   57.867  1.00 53.74  ? 141 GLU C CA  1 
ATOM 6499  C C   . GLU C 1 147 ? 6.467   9.394   56.986  1.00 57.57  ? 141 GLU C C   1 
ATOM 6500  O O   . GLU C 1 147 ? 7.586   9.540   57.469  1.00 51.35  ? 141 GLU C O   1 
ATOM 6501  C CB  . GLU C 1 147 ? 5.071   7.516   57.828  1.00 58.27  ? 141 GLU C CB  1 
ATOM 6502  C CG  . GLU C 1 147 ? 4.050   7.019   58.848  1.00 71.06  ? 141 GLU C CG  1 
ATOM 6503  C CD  . GLU C 1 147 ? 4.410   7.095   60.327  1.00 78.69  ? 141 GLU C CD  1 
ATOM 6504  O OE1 . GLU C 1 147 ? 5.608   7.305   60.684  1.00 73.95  ? 141 GLU C OE1 1 
ATOM 6505  O OE2 . GLU C 1 147 ? 3.430   6.941   61.116  1.00 77.51  ? 141 GLU C OE2 1 
ATOM 6506  N N   . ILE C 1 148 ? 6.185   9.563   55.690  1.00 65.86  ? 142 ILE C N   1 
ATOM 6507  C CA  . ILE C 1 148 ? 7.225   9.822   54.708  1.00 65.52  ? 142 ILE C CA  1 
ATOM 6508  C C   . ILE C 1 148 ? 7.792   11.220  54.936  1.00 62.43  ? 142 ILE C C   1 
ATOM 6509  O O   . ILE C 1 148 ? 8.998   11.407  54.816  1.00 67.42  ? 142 ILE C O   1 
ATOM 6510  C CB  . ILE C 1 148 ? 6.718   9.670   53.263  1.00 65.66  ? 142 ILE C CB  1 
ATOM 6511  C CG1 . ILE C 1 148 ? 6.013   8.315   53.026  1.00 79.80  ? 142 ILE C CG1 1 
ATOM 6512  C CG2 . ILE C 1 148 ? 7.861   9.910   52.274  1.00 60.66  ? 142 ILE C CG2 1 
ATOM 6513  C CD1 . ILE C 1 148 ? 6.916   7.165   52.609  1.00 79.37  ? 142 ILE C CD1 1 
ATOM 6514  N N   . ALA C 1 149 ? 6.923   12.195  55.237  1.00 60.17  ? 143 ALA C N   1 
ATOM 6515  C CA  . ALA C 1 149 ? 7.328   13.596  55.324  1.00 63.54  ? 143 ALA C CA  1 
ATOM 6516  C C   . ALA C 1 149 ? 8.112   13.846  56.610  1.00 64.33  ? 143 ALA C C   1 
ATOM 6517  O O   . ALA C 1 149 ? 9.127   14.537  56.609  1.00 69.62  ? 143 ALA C O   1 
ATOM 6518  C CB  . ALA C 1 149 ? 6.113   14.503  55.242  1.00 62.29  ? 143 ALA C CB  1 
ATOM 6519  N N   . ARG C 1 150 ? 7.575   13.301  57.701  1.00 65.91  ? 144 ARG C N   1 
ATOM 6520  C CA  . ARG C 1 150 ? 8.197   13.250  59.015  1.00 63.43  ? 144 ARG C CA  1 
ATOM 6521  C C   . ARG C 1 150 ? 9.653   12.764  58.945  1.00 58.64  ? 144 ARG C C   1 
ATOM 6522  O O   . ARG C 1 150 ? 10.538  13.319  59.607  1.00 50.58  ? 144 ARG C O   1 
ATOM 6523  C CB  . ARG C 1 150 ? 7.262   12.291  59.768  1.00 68.46  ? 144 ARG C CB  1 
ATOM 6524  C CG  . ARG C 1 150 ? 7.359   12.207  61.279  1.00 70.23  ? 144 ARG C CG  1 
ATOM 6525  C CD  . ARG C 1 150 ? 6.748   10.911  61.782  1.00 68.02  ? 144 ARG C CD  1 
ATOM 6526  N NE  . ARG C 1 150 ? 6.869   10.858  63.239  1.00 67.87  ? 144 ARG C NE  1 
ATOM 6527  C CZ  . ARG C 1 150 ? 6.671   9.778   63.969  1.00 76.66  ? 144 ARG C CZ  1 
ATOM 6528  N NH1 . ARG C 1 150 ? 6.370   8.621   63.392  1.00 73.35  ? 144 ARG C NH1 1 
ATOM 6529  N NH2 . ARG C 1 150 ? 6.801   9.868   65.284  1.00 88.48  ? 144 ARG C NH2 1 
ATOM 6530  N N   . ARG C 1 151 ? 9.898   11.704  58.159  1.00 56.07  ? 145 ARG C N   1 
ATOM 6531  C CA  . ARG C 1 151 ? 11.197  11.046  58.116  1.00 59.53  ? 145 ARG C CA  1 
ATOM 6532  C C   . ARG C 1 151 ? 12.172  11.784  57.203  1.00 60.07  ? 145 ARG C C   1 
ATOM 6533  O O   . ARG C 1 151 ? 13.263  12.143  57.631  1.00 80.43  ? 145 ARG C O   1 
ATOM 6534  C CB  . ARG C 1 151 ? 11.077  9.605   57.614  1.00 60.49  ? 145 ARG C CB  1 
ATOM 6535  C CG  . ARG C 1 151 ? 10.484  8.689   58.666  1.00 63.42  ? 145 ARG C CG  1 
ATOM 6536  C CD  . ARG C 1 151 ? 9.656   7.550   58.110  1.00 65.33  ? 145 ARG C CD  1 
ATOM 6537  N NE  . ARG C 1 151 ? 8.797   7.074   59.200  1.00 67.48  ? 145 ARG C NE  1 
ATOM 6538  C CZ  . ARG C 1 151 ? 9.260   6.606   60.355  1.00 67.77  ? 145 ARG C CZ  1 
ATOM 6539  N NH1 . ARG C 1 151 ? 10.546  6.309   60.489  1.00 63.81  ? 145 ARG C NH1 1 
ATOM 6540  N NH2 . ARG C 1 151 ? 8.423   6.404   61.360  1.00 72.20  ? 145 ARG C NH2 1 
ATOM 6541  N N   . HIS C 1 152 ? 11.799  11.931  55.932  1.00 54.59  ? 146 HIS C N   1 
ATOM 6542  C CA  . HIS C 1 152 ? 12.598  12.658  54.966  1.00 58.21  ? 146 HIS C CA  1 
ATOM 6543  C C   . HIS C 1 152 ? 11.993  14.043  54.712  1.00 54.97  ? 146 HIS C C   1 
ATOM 6544  O O   . HIS C 1 152 ? 11.200  14.227  53.792  1.00 45.90  ? 146 HIS C O   1 
ATOM 6545  C CB  . HIS C 1 152 ? 12.684  11.885  53.646  1.00 63.21  ? 146 HIS C CB  1 
ATOM 6546  C CG  . HIS C 1 152 ? 12.754  10.408  53.761  1.00 66.39  ? 146 HIS C CG  1 
ATOM 6547  N ND1 . HIS C 1 152 ? 11.683  9.627   53.385  1.00 72.68  ? 146 HIS C ND1 1 
ATOM 6548  C CD2 . HIS C 1 152 ? 13.730  9.569   54.122  1.00 75.73  ? 146 HIS C CD2 1 
ATOM 6549  C CE1 . HIS C 1 152 ? 12.002  8.348   53.548  1.00 85.16  ? 146 HIS C CE1 1 
ATOM 6550  N NE2 . HIS C 1 152 ? 13.240  8.289   54.000  1.00 87.31  ? 146 HIS C NE2 1 
ATOM 6551  N N   . PRO C 1 153 ? 12.418  15.103  55.437  1.00 59.16  ? 147 PRO C N   1 
ATOM 6552  C CA  . PRO C 1 153 ? 11.727  16.394  55.384  1.00 55.77  ? 147 PRO C CA  1 
ATOM 6553  C C   . PRO C 1 153 ? 12.217  17.435  54.373  1.00 54.06  ? 147 PRO C C   1 
ATOM 6554  O O   . PRO C 1 153 ? 12.024  18.633  54.560  1.00 43.74  ? 147 PRO C O   1 
ATOM 6555  C CB  . PRO C 1 153 ? 12.018  16.806  56.830  1.00 61.54  ? 147 PRO C CB  1 
ATOM 6556  C CG  . PRO C 1 153 ? 13.482  16.449  57.047  1.00 61.30  ? 147 PRO C CG  1 
ATOM 6557  C CD  . PRO C 1 153 ? 13.637  15.152  56.271  1.00 65.11  ? 147 PRO C CD  1 
ATOM 6558  N N   . TYR C 1 154 ? 12.859  16.966  53.296  1.00 63.60  ? 148 TYR C N   1 
ATOM 6559  C CA  . TYR C 1 154 ? 13.235  17.809  52.170  1.00 59.45  ? 148 TYR C CA  1 
ATOM 6560  C C   . TYR C 1 154 ? 12.634  17.257  50.882  1.00 53.71  ? 148 TYR C C   1 
ATOM 6561  O O   . TYR C 1 154 ? 13.038  17.650  49.792  1.00 50.32  ? 148 TYR C O   1 
ATOM 6562  C CB  . TYR C 1 154 ? 14.760  17.858  52.059  1.00 64.88  ? 148 TYR C CB  1 
ATOM 6563  C CG  . TYR C 1 154 ? 15.453  18.710  53.113  1.00 64.96  ? 148 TYR C CG  1 
ATOM 6564  C CD1 . TYR C 1 154 ? 15.390  20.099  53.052  1.00 66.85  ? 148 TYR C CD1 1 
ATOM 6565  C CD2 . TYR C 1 154 ? 16.178  18.131  54.146  1.00 54.50  ? 148 TYR C CD2 1 
ATOM 6566  C CE1 . TYR C 1 154 ? 16.020  20.890  53.990  1.00 62.17  ? 148 TYR C CE1 1 
ATOM 6567  C CE2 . TYR C 1 154 ? 16.834  18.912  55.074  1.00 54.64  ? 148 TYR C CE2 1 
ATOM 6568  C CZ  . TYR C 1 154 ? 16.750  20.290  54.995  1.00 61.38  ? 148 TYR C CZ  1 
ATOM 6569  O OH  . TYR C 1 154 ? 17.370  21.089  55.905  1.00 74.96  ? 148 TYR C OH  1 
ATOM 6570  N N   . PHE C 1 155 ? 11.661  16.353  51.032  1.00 49.23  ? 149 PHE C N   1 
ATOM 6571  C CA  . PHE C 1 155 ? 10.967  15.741  49.914  1.00 48.80  ? 149 PHE C CA  1 
ATOM 6572  C C   . PHE C 1 155 ? 10.312  16.828  49.057  1.00 46.35  ? 149 PHE C C   1 
ATOM 6573  O O   . PHE C 1 155 ? 9.719   17.772  49.577  1.00 45.85  ? 149 PHE C O   1 
ATOM 6574  C CB  . PHE C 1 155 ? 9.943   14.746  50.484  1.00 51.55  ? 149 PHE C CB  1 
ATOM 6575  C CG  . PHE C 1 155 ? 9.799   13.435  49.723  1.00 49.30  ? 149 PHE C CG  1 
ATOM 6576  C CD1 . PHE C 1 155 ? 9.189   13.393  48.478  1.00 47.54  ? 149 PHE C CD1 1 
ATOM 6577  C CD2 . PHE C 1 155 ? 10.265  12.251  50.271  1.00 47.68  ? 149 PHE C CD2 1 
ATOM 6578  C CE1 . PHE C 1 155 ? 9.081   12.201  47.793  1.00 47.89  ? 149 PHE C CE1 1 
ATOM 6579  C CE2 . PHE C 1 155 ? 10.160  11.069  49.576  1.00 48.62  ? 149 PHE C CE2 1 
ATOM 6580  C CZ  . PHE C 1 155 ? 9.574   11.047  48.339  1.00 47.55  ? 149 PHE C CZ  1 
ATOM 6581  N N   . TYR C 1 156 ? 10.410  16.674  47.734  1.00 43.79  ? 150 TYR C N   1 
ATOM 6582  C CA  . TYR C 1 156 ? 9.670   17.505  46.800  1.00 42.61  ? 150 TYR C CA  1 
ATOM 6583  C C   . TYR C 1 156 ? 8.177   17.326  47.035  1.00 40.91  ? 150 TYR C C   1 
ATOM 6584  O O   . TYR C 1 156 ? 7.637   16.257  46.793  1.00 44.79  ? 150 TYR C O   1 
ATOM 6585  C CB  . TYR C 1 156 ? 10.037  17.026  45.398  1.00 43.87  ? 150 TYR C CB  1 
ATOM 6586  C CG  . TYR C 1 156 ? 9.745   17.936  44.217  1.00 43.26  ? 150 TYR C CG  1 
ATOM 6587  C CD1 . TYR C 1 156 ? 9.835   19.317  44.294  1.00 45.22  ? 150 TYR C CD1 1 
ATOM 6588  C CD2 . TYR C 1 156 ? 9.446   17.383  42.985  1.00 48.61  ? 150 TYR C CD2 1 
ATOM 6589  C CE1 . TYR C 1 156 ? 9.610   20.115  43.182  1.00 48.38  ? 150 TYR C CE1 1 
ATOM 6590  C CE2 . TYR C 1 156 ? 9.225   18.163  41.864  1.00 52.26  ? 150 TYR C CE2 1 
ATOM 6591  C CZ  . TYR C 1 156 ? 9.313   19.534  41.960  1.00 50.32  ? 150 TYR C CZ  1 
ATOM 6592  O OH  . TYR C 1 156 ? 9.088   20.217  40.804  1.00 46.80  ? 150 TYR C OH  1 
ATOM 6593  N N   . ALA C 1 157 ? 7.512   18.375  47.495  1.00 44.12  ? 151 ALA C N   1 
ATOM 6594  C CA  . ALA C 1 157 ? 6.120   18.264  47.889  1.00 50.96  ? 151 ALA C CA  1 
ATOM 6595  C C   . ALA C 1 157 ? 5.268   17.645  46.774  1.00 51.97  ? 151 ALA C C   1 
ATOM 6596  O O   . ALA C 1 157 ? 4.515   16.701  47.017  1.00 49.06  ? 151 ALA C O   1 
ATOM 6597  C CB  . ALA C 1 157 ? 5.606   19.630  48.320  1.00 54.91  ? 151 ALA C CB  1 
ATOM 6598  N N   . PRO C 1 158 ? 5.309   18.157  45.523  1.00 58.11  ? 152 PRO C N   1 
ATOM 6599  C CA  . PRO C 1 158 ? 4.410   17.654  44.487  1.00 63.43  ? 152 PRO C CA  1 
ATOM 6600  C C   . PRO C 1 158 ? 4.639   16.167  44.236  1.00 65.61  ? 152 PRO C C   1 
ATOM 6601  O O   . PRO C 1 158 ? 3.686   15.410  44.070  1.00 73.29  ? 152 PRO C O   1 
ATOM 6602  C CB  . PRO C 1 158 ? 4.735   18.532  43.259  1.00 67.99  ? 152 PRO C CB  1 
ATOM 6603  C CG  . PRO C 1 158 ? 5.413   19.762  43.839  1.00 64.40  ? 152 PRO C CG  1 
ATOM 6604  C CD  . PRO C 1 158 ? 6.181   19.243  45.041  1.00 62.92  ? 152 PRO C CD  1 
ATOM 6605  N N   . GLU C 1 159 ? 5.912   15.760  44.239  1.00 66.84  ? 153 GLU C N   1 
ATOM 6606  C CA  . GLU C 1 159 ? 6.292   14.393  43.915  1.00 74.77  ? 153 GLU C CA  1 
ATOM 6607  C C   . GLU C 1 159 ? 5.773   13.445  44.996  1.00 60.33  ? 153 GLU C C   1 
ATOM 6608  O O   . GLU C 1 159 ? 5.455   12.299  44.709  1.00 62.98  ? 153 GLU C O   1 
ATOM 6609  C CB  . GLU C 1 159 ? 7.814   14.324  43.728  1.00 91.67  ? 153 GLU C CB  1 
ATOM 6610  C CG  . GLU C 1 159 ? 8.340   13.107  42.963  1.00 100.42 ? 153 GLU C CG  1 
ATOM 6611  C CD  . GLU C 1 159 ? 7.697   12.842  41.608  1.00 104.94 ? 153 GLU C CD  1 
ATOM 6612  O OE1 . GLU C 1 159 ? 7.460   13.823  40.867  1.00 102.24 ? 153 GLU C OE1 1 
ATOM 6613  O OE2 . GLU C 1 159 ? 7.438   11.656  41.288  1.00 107.31 ? 153 GLU C OE2 1 
ATOM 6614  N N   . LEU C 1 160 ? 5.677   13.930  46.233  1.00 50.01  ? 154 LEU C N   1 
ATOM 6615  C CA  . LEU C 1 160 ? 5.129   13.133  47.312  1.00 50.40  ? 154 LEU C CA  1 
ATOM 6616  C C   . LEU C 1 160 ? 3.610   13.031  47.214  1.00 49.67  ? 154 LEU C C   1 
ATOM 6617  O O   . LEU C 1 160 ? 3.054   12.064  47.708  1.00 45.44  ? 154 LEU C O   1 
ATOM 6618  C CB  . LEU C 1 160 ? 5.525   13.727  48.657  1.00 55.86  ? 154 LEU C CB  1 
ATOM 6619  C CG  . LEU C 1 160 ? 5.167   12.891  49.891  1.00 56.17  ? 154 LEU C CG  1 
ATOM 6620  C CD1 . LEU C 1 160 ? 5.690   11.456  49.793  1.00 57.27  ? 154 LEU C CD1 1 
ATOM 6621  C CD2 . LEU C 1 160 ? 5.704   13.586  51.139  1.00 53.36  ? 154 LEU C CD2 1 
ATOM 6622  N N   . LEU C 1 161 ? 2.932   14.028  46.635  1.00 53.87  ? 155 LEU C N   1 
ATOM 6623  C CA  . LEU C 1 161 ? 1.514   13.890  46.330  1.00 60.63  ? 155 LEU C CA  1 
ATOM 6624  C C   . LEU C 1 161 ? 1.294   12.773  45.313  1.00 61.45  ? 155 LEU C C   1 
ATOM 6625  O O   . LEU C 1 161 ? 0.221   12.164  45.264  1.00 62.01  ? 155 LEU C O   1 
ATOM 6626  C CB  . LEU C 1 161 ? 0.922   15.180  45.772  1.00 66.73  ? 155 LEU C CB  1 
ATOM 6627  C CG  . LEU C 1 161 ? 0.693   16.321  46.761  1.00 74.25  ? 155 LEU C CG  1 
ATOM 6628  C CD1 . LEU C 1 161 ? -0.572  17.044  46.322  1.00 74.79  ? 155 LEU C CD1 1 
ATOM 6629  C CD2 . LEU C 1 161 ? 0.599   15.850  48.206  1.00 78.10  ? 155 LEU C CD2 1 
ATOM 6630  N N   . PHE C 1 162 ? 2.291   12.574  44.449  1.00 58.26  ? 156 PHE C N   1 
ATOM 6631  C CA  . PHE C 1 162 ? 2.208   11.544  43.434  1.00 61.56  ? 156 PHE C CA  1 
ATOM 6632  C C   . PHE C 1 162 ? 2.377   10.179  44.103  1.00 58.86  ? 156 PHE C C   1 
ATOM 6633  O O   . PHE C 1 162 ? 1.460   9.370   44.059  1.00 67.27  ? 156 PHE C O   1 
ATOM 6634  C CB  . PHE C 1 162 ? 3.218   11.819  42.316  1.00 62.31  ? 156 PHE C CB  1 
ATOM 6635  C CG  . PHE C 1 162 ? 3.067   10.823  41.179  1.00 68.06  ? 156 PHE C CG  1 
ATOM 6636  C CD1 . PHE C 1 162 ? 1.822   10.608  40.578  1.00 74.16  ? 156 PHE C CD1 1 
ATOM 6637  C CD2 . PHE C 1 162 ? 4.143   10.047  40.772  1.00 70.13  ? 156 PHE C CD2 1 
ATOM 6638  C CE1 . PHE C 1 162 ? 1.667   9.675   39.560  1.00 70.29  ? 156 PHE C CE1 1 
ATOM 6639  C CE2 . PHE C 1 162 ? 3.984   9.119   39.749  1.00 77.78  ? 156 PHE C CE2 1 
ATOM 6640  C CZ  . PHE C 1 162 ? 2.747   8.933   39.146  1.00 73.64  ? 156 PHE C CZ  1 
ATOM 6641  N N   . PHE C 1 163 ? 3.538   9.944   44.731  1.00 56.33  ? 157 PHE C N   1 
ATOM 6642  C CA  . PHE C 1 163 ? 3.851   8.725   45.470  1.00 53.16  ? 157 PHE C CA  1 
ATOM 6643  C C   . PHE C 1 163 ? 2.668   8.191   46.283  1.00 49.98  ? 157 PHE C C   1 
ATOM 6644  O O   . PHE C 1 163 ? 2.517   6.989   46.435  1.00 51.95  ? 157 PHE C O   1 
ATOM 6645  C CB  . PHE C 1 163 ? 4.998   8.964   46.456  1.00 54.26  ? 157 PHE C CB  1 
ATOM 6646  C CG  . PHE C 1 163 ? 6.387   8.757   45.880  1.00 56.20  ? 157 PHE C CG  1 
ATOM 6647  C CD1 . PHE C 1 163 ? 6.886   7.480   45.712  1.00 65.01  ? 157 PHE C CD1 1 
ATOM 6648  C CD2 . PHE C 1 163 ? 7.199   9.824   45.534  1.00 59.90  ? 157 PHE C CD2 1 
ATOM 6649  C CE1 . PHE C 1 163 ? 8.160   7.272   45.208  1.00 67.89  ? 157 PHE C CE1 1 
ATOM 6650  C CE2 . PHE C 1 163 ? 8.471   9.609   45.031  1.00 61.71  ? 157 PHE C CE2 1 
ATOM 6651  C CZ  . PHE C 1 163 ? 8.950   8.335   44.872  1.00 61.73  ? 157 PHE C CZ  1 
ATOM 6652  N N   . ALA C 1 164 ? 1.858   9.070   46.868  1.00 50.07  ? 158 ALA C N   1 
ATOM 6653  C CA  . ALA C 1 164 ? 0.674   8.640   47.598  1.00 50.49  ? 158 ALA C CA  1 
ATOM 6654  C C   . ALA C 1 164 ? -0.311  7.948   46.656  1.00 53.75  ? 158 ALA C C   1 
ATOM 6655  O O   . ALA C 1 164 ? -0.900  6.941   47.033  1.00 53.69  ? 158 ALA C O   1 
ATOM 6656  C CB  . ALA C 1 164 ? 0.022   9.824   48.295  1.00 50.82  ? 158 ALA C CB  1 
ATOM 6657  N N   . LYS C 1 165 ? -0.492  8.515   45.450  1.00 60.10  ? 159 LYS C N   1 
ATOM 6658  C CA  . LYS C 1 165 ? -1.354  7.968   44.411  1.00 62.93  ? 159 LYS C CA  1 
ATOM 6659  C C   . LYS C 1 165 ? -0.862  6.590   43.946  1.00 68.43  ? 159 LYS C C   1 
ATOM 6660  O O   . LYS C 1 165 ? -1.676  5.684   43.732  1.00 69.03  ? 159 LYS C O   1 
ATOM 6661  C CB  . LYS C 1 165 ? -1.454  8.981   43.264  1.00 64.24  ? 159 LYS C CB  1 
ATOM 6662  C CG  . LYS C 1 165 ? -2.294  10.206  43.601  1.00 75.43  ? 159 LYS C CG  1 
ATOM 6663  C CD  . LYS C 1 165 ? -3.765  9.911   43.901  1.00 85.24  ? 159 LYS C CD  1 
ATOM 6664  C CE  . LYS C 1 165 ? -4.473  9.207   42.768  1.00 94.83  ? 159 LYS C CE  1 
ATOM 6665  N NZ  . LYS C 1 165 ? -5.861  8.835   43.059  1.00 97.83  ? 159 LYS C NZ  1 
ATOM 6666  N N   . ARG C 1 166 ? 0.464   6.429   43.801  1.00 65.58  ? 160 ARG C N   1 
ATOM 6667  C CA  . ARG C 1 166 ? 1.058   5.153   43.424  1.00 66.94  ? 160 ARG C CA  1 
ATOM 6668  C C   . ARG C 1 166 ? 0.905   4.112   44.541  1.00 68.06  ? 160 ARG C C   1 
ATOM 6669  O O   . ARG C 1 166 ? 0.877   2.912   44.268  1.00 75.42  ? 160 ARG C O   1 
ATOM 6670  C CB  . ARG C 1 166 ? 2.507   5.361   42.968  1.00 65.54  ? 160 ARG C CB  1 
ATOM 6671  C CG  . ARG C 1 166 ? 2.622   5.562   41.464  1.00 69.29  ? 160 ARG C CG  1 
ATOM 6672  C CD  . ARG C 1 166 ? 3.960   6.189   41.104  1.00 77.96  ? 160 ARG C CD  1 
ATOM 6673  N NE  . ARG C 1 166 ? 5.176   5.457   41.497  1.00 84.26  ? 160 ARG C NE  1 
ATOM 6674  C CZ  . ARG C 1 166 ? 6.392   6.008   41.653  1.00 86.49  ? 160 ARG C CZ  1 
ATOM 6675  N NH1 . ARG C 1 166 ? 6.537   7.323   41.694  1.00 91.65  ? 160 ARG C NH1 1 
ATOM 6676  N NH2 . ARG C 1 166 ? 7.470   5.256   41.814  1.00 81.15  ? 160 ARG C NH2 1 
ATOM 6677  N N   . TYR C 1 167 ? 0.802   4.571   45.793  1.00 65.81  ? 161 TYR C N   1 
ATOM 6678  C CA  . TYR C 1 167 ? 0.490   3.725   46.936  1.00 60.18  ? 161 TYR C CA  1 
ATOM 6679  C C   . TYR C 1 167 ? -0.959  3.257   46.833  1.00 58.19  ? 161 TYR C C   1 
ATOM 6680  O O   . TYR C 1 167 ? -1.195  2.070   46.655  1.00 60.88  ? 161 TYR C O   1 
ATOM 6681  C CB  . TYR C 1 167 ? 0.763   4.571   48.182  1.00 64.86  ? 161 TYR C CB  1 
ATOM 6682  C CG  . TYR C 1 167 ? 0.761   3.877   49.535  1.00 67.43  ? 161 TYR C CG  1 
ATOM 6683  C CD1 . TYR C 1 167 ? 1.593   2.797   49.800  1.00 73.87  ? 161 TYR C CD1 1 
ATOM 6684  C CD2 . TYR C 1 167 ? -0.061  4.325   50.559  1.00 64.33  ? 161 TYR C CD2 1 
ATOM 6685  C CE1 . TYR C 1 167 ? 1.597   2.176   51.040  1.00 73.47  ? 161 TYR C CE1 1 
ATOM 6686  C CE2 . TYR C 1 167 ? -0.068  3.710   51.799  1.00 66.55  ? 161 TYR C CE2 1 
ATOM 6687  C CZ  . TYR C 1 167 ? 0.759   2.632   52.042  1.00 66.51  ? 161 TYR C CZ  1 
ATOM 6688  O OH  . TYR C 1 167 ? 0.754   2.062   53.277  1.00 62.86  ? 161 TYR C OH  1 
ATOM 6689  N N   . LYS C 1 168 ? -1.915  4.199   46.898  1.00 57.50  ? 162 LYS C N   1 
ATOM 6690  C CA  . LYS C 1 168 ? -3.341  3.917   46.757  1.00 58.13  ? 162 LYS C CA  1 
ATOM 6691  C C   . LYS C 1 168 ? -3.592  2.968   45.585  1.00 54.03  ? 162 LYS C C   1 
ATOM 6692  O O   . LYS C 1 168 ? -4.535  2.175   45.623  1.00 46.58  ? 162 LYS C O   1 
ATOM 6693  C CB  . LYS C 1 168 ? -4.106  5.230   46.545  1.00 62.63  ? 162 LYS C CB  1 
ATOM 6694  C CG  . LYS C 1 168 ? -5.637  5.202   46.439  1.00 69.34  ? 162 LYS C CG  1 
ATOM 6695  C CD  . LYS C 1 168 ? -6.173  6.568   45.992  1.00 75.18  ? 162 LYS C CD  1 
ATOM 6696  C CE  . LYS C 1 168 ? -7.651  6.841   46.136  1.00 76.34  ? 162 LYS C CE  1 
ATOM 6697  N NZ  . LYS C 1 168 ? -8.481  6.331   45.043  1.00 76.13  ? 162 LYS C NZ  1 
ATOM 6698  N N   . ALA C 1 169 ? -2.746  3.078   44.548  1.00 53.58  ? 163 ALA C N   1 
ATOM 6699  C CA  . ALA C 1 169 ? -2.849  2.261   43.349  1.00 55.78  ? 163 ALA C CA  1 
ATOM 6700  C C   . ALA C 1 169 ? -2.482  0.807   43.636  1.00 56.24  ? 163 ALA C C   1 
ATOM 6701  O O   . ALA C 1 169 ? -3.146  -0.111  43.144  1.00 50.89  ? 163 ALA C O   1 
ATOM 6702  C CB  . ALA C 1 169 ? -1.962  2.832   42.266  1.00 55.45  ? 163 ALA C CB  1 
ATOM 6703  N N   . ALA C 1 170 ? -1.395  0.630   44.401  1.00 59.90  ? 164 ALA C N   1 
ATOM 6704  C CA  . ALA C 1 170 ? -0.885  -0.680  44.779  1.00 59.24  ? 164 ALA C CA  1 
ATOM 6705  C C   . ALA C 1 170 ? -1.905  -1.429  45.639  1.00 61.49  ? 164 ALA C C   1 
ATOM 6706  O O   . ALA C 1 170 ? -1.955  -2.653  45.608  1.00 63.55  ? 164 ALA C O   1 
ATOM 6707  C CB  . ALA C 1 170 ? 0.445   -0.533  45.490  1.00 54.52  ? 164 ALA C CB  1 
ATOM 6708  N N   . PHE C 1 171 ? -2.743  -0.699  46.379  1.00 67.04  ? 165 PHE C N   1 
ATOM 6709  C CA  . PHE C 1 171 ? -3.703  -1.322  47.278  1.00 77.02  ? 165 PHE C CA  1 
ATOM 6710  C C   . PHE C 1 171 ? -5.002  -1.632  46.534  1.00 79.01  ? 165 PHE C C   1 
ATOM 6711  O O   . PHE C 1 171 ? -5.564  -2.711  46.703  1.00 84.31  ? 165 PHE C O   1 
ATOM 6712  C CB  . PHE C 1 171 ? -3.966  -0.474  48.531  1.00 81.24  ? 165 PHE C CB  1 
ATOM 6713  C CG  . PHE C 1 171 ? -2.827  -0.455  49.544  1.00 76.59  ? 165 PHE C CG  1 
ATOM 6714  C CD1 . PHE C 1 171 ? -1.551  -0.019  49.192  1.00 75.33  ? 165 PHE C CD1 1 
ATOM 6715  C CD2 . PHE C 1 171 ? -3.024  -0.931  50.831  1.00 70.66  ? 165 PHE C CD2 1 
ATOM 6716  C CE1 . PHE C 1 171 ? -0.519  -0.022  50.111  1.00 68.50  ? 165 PHE C CE1 1 
ATOM 6717  C CE2 . PHE C 1 171 ? -1.981  -0.948  51.737  1.00 71.41  ? 165 PHE C CE2 1 
ATOM 6718  C CZ  . PHE C 1 171 ? -0.734  -0.488  51.380  1.00 68.64  ? 165 PHE C CZ  1 
ATOM 6719  N N   . THR C 1 172 ? -5.494  -0.699  45.716  1.00 77.28  ? 166 THR C N   1 
ATOM 6720  C CA  . THR C 1 172 ? -6.710  -0.977  44.970  1.00 77.81  ? 166 THR C CA  1 
ATOM 6721  C C   . THR C 1 172 ? -6.496  -2.249  44.147  1.00 78.42  ? 166 THR C C   1 
ATOM 6722  O O   . THR C 1 172 ? -7.347  -3.133  44.166  1.00 78.74  ? 166 THR C O   1 
ATOM 6723  C CB  . THR C 1 172 ? -7.118  0.229   44.126  1.00 72.28  ? 166 THR C CB  1 
ATOM 6724  O OG1 . THR C 1 172 ? -5.881  0.861   43.823  1.00 67.58  ? 166 THR C OG1 1 
ATOM 6725  C CG2 . THR C 1 172 ? -8.019  1.194   44.879  1.00 70.60  ? 166 THR C CG2 1 
ATOM 6726  N N   . GLU C 1 173 ? -5.334  -2.437  43.554  1.00 81.19  ? 167 GLU C N   1 
ATOM 6727  C CA  . GLU C 1 173 ? -5.203  -3.658  42.729  1.00 81.15  ? 167 GLU C CA  1 
ATOM 6728  C C   . GLU C 1 173 ? -4.868  -4.847  43.617  1.00 67.24  ? 167 GLU C C   1 
ATOM 6729  O O   . GLU C 1 173 ? -5.585  -5.851  43.562  1.00 63.41  ? 167 GLU C O   1 
ATOM 6730  C CB  . GLU C 1 173 ? -4.096  -3.419  41.712  1.00 94.22  ? 167 GLU C CB  1 
ATOM 6731  C CG  . GLU C 1 173 ? -3.396  -4.685  41.231  1.00 102.15 ? 167 GLU C CG  1 
ATOM 6732  C CD  . GLU C 1 173 ? -2.194  -4.338  40.373  1.00 107.62 ? 167 GLU C CD  1 
ATOM 6733  O OE1 . GLU C 1 173 ? -1.779  -3.163  40.414  1.00 113.61 ? 167 GLU C OE1 1 
ATOM 6734  O OE2 . GLU C 1 173 ? -1.674  -5.226  39.670  1.00 107.66 ? 167 GLU C OE2 1 
ATOM 6735  N N   . CYS C 1 174 ? -3.809  -4.730  44.394  1.00 64.79  ? 168 CYS C N   1 
ATOM 6736  C CA  . CYS C 1 174 ? -3.333  -5.876  45.207  1.00 69.97  ? 168 CYS C CA  1 
ATOM 6737  C C   . CYS C 1 174 ? -4.349  -6.338  46.268  1.00 66.54  ? 168 CYS C C   1 
ATOM 6738  O O   . CYS C 1 174 ? -4.482  -7.553  46.429  1.00 67.18  ? 168 CYS C O   1 
ATOM 6739  C CB  . CYS C 1 174 ? -1.955  -5.540  45.761  1.00 63.90  ? 168 CYS C CB  1 
ATOM 6740  S SG  . CYS C 1 174 ? -0.666  -5.815  44.530  1.00 65.32  ? 168 CYS C SG  1 
ATOM 6741  N N   . CYS C 1 175 ? -5.034  -5.428  46.955  1.00 66.89  ? 169 CYS C N   1 
ATOM 6742  C CA  . CYS C 1 175 ? -5.921  -5.869  48.066  1.00 73.07  ? 169 CYS C CA  1 
ATOM 6743  C C   . CYS C 1 175 ? -7.339  -6.112  47.510  1.00 76.95  ? 169 CYS C C   1 
ATOM 6744  O O   . CYS C 1 175 ? -7.487  -7.034  46.678  1.00 72.32  ? 169 CYS C O   1 
ATOM 6745  C CB  . CYS C 1 175 ? -5.855  -4.921  49.272  1.00 75.73  ? 169 CYS C CB  1 
ATOM 6746  S SG  . CYS C 1 175 ? -4.236  -4.839  50.100  1.00 74.27  ? 169 CYS C SG  1 
ATOM 6747  N N   . ASP C 1 179 ? -1.360  -10.838 41.763  1.00 184.13 ? 173 ASP C N   1 
ATOM 6748  C CA  . ASP C 1 179 ? -2.713  -11.439 41.921  1.00 162.51 ? 173 ASP C CA  1 
ATOM 6749  C C   . ASP C 1 179 ? -3.056  -11.547 43.404  1.00 139.58 ? 173 ASP C C   1 
ATOM 6750  O O   . ASP C 1 179 ? -2.824  -10.563 44.134  1.00 115.14 ? 173 ASP C O   1 
ATOM 6751  C CB  . ASP C 1 179 ? -2.836  -12.798 41.259  1.00 162.77 ? 173 ASP C CB  1 
ATOM 6752  C CG  . ASP C 1 179 ? -4.255  -13.201 40.887  1.00 158.06 ? 173 ASP C CG  1 
ATOM 6753  O OD1 . ASP C 1 179 ? -5.051  -12.297 40.558  1.00 173.67 ? 173 ASP C OD1 1 
ATOM 6754  O OD2 . ASP C 1 179 ? -4.554  -14.411 40.942  1.00 139.69 ? 173 ASP C OD2 1 
ATOM 6755  N N   . LYS C 1 180 ? -3.610  -12.681 43.830  1.00 126.93 ? 174 LYS C N   1 
ATOM 6756  C CA  . LYS C 1 180 ? -4.058  -12.767 45.239  1.00 122.38 ? 174 LYS C CA  1 
ATOM 6757  C C   . LYS C 1 180 ? -2.886  -12.628 46.225  1.00 102.33 ? 174 LYS C C   1 
ATOM 6758  O O   . LYS C 1 180 ? -3.024  -11.850 47.193  1.00 79.05  ? 174 LYS C O   1 
ATOM 6759  C CB  . LYS C 1 180 ? -4.767  -14.113 45.428  1.00 121.60 ? 174 LYS C CB  1 
ATOM 6760  C CG  . LYS C 1 180 ? -4.541  -14.803 46.766  1.00 120.31 ? 174 LYS C CG  1 
ATOM 6761  C CD  . LYS C 1 180 ? -4.398  -16.316 46.665  1.00 108.56 ? 174 LYS C CD  1 
ATOM 6762  C CE  . LYS C 1 180 ? -5.676  -17.001 46.288  1.00 96.02  ? 174 LYS C CE  1 
ATOM 6763  N NZ  . LYS C 1 180 ? -6.406  -17.513 47.450  1.00 90.28  ? 174 LYS C NZ  1 
ATOM 6764  N N   . ALA C 1 181 ? -1.740  -13.250 45.954  1.00 85.92  ? 175 ALA C N   1 
ATOM 6765  C CA  . ALA C 1 181 ? -0.703  -13.220 47.008  1.00 84.20  ? 175 ALA C CA  1 
ATOM 6766  C C   . ALA C 1 181 ? 0.616   -12.572 46.620  1.00 98.57  ? 175 ALA C C   1 
ATOM 6767  O O   . ALA C 1 181 ? 1.140   -12.946 45.554  1.00 97.78  ? 175 ALA C O   1 
ATOM 6768  C CB  . ALA C 1 181 ? -0.434  -14.635 47.429  1.00 76.05  ? 175 ALA C CB  1 
ATOM 6769  N N   . ALA C 1 182 ? 1.104   -11.617 47.417  1.00 105.11 ? 176 ALA C N   1 
ATOM 6770  C CA  . ALA C 1 182 ? 2.484   -11.091 47.284  1.00 92.18  ? 176 ALA C CA  1 
ATOM 6771  C C   . ALA C 1 182 ? 2.691   -10.054 46.187  1.00 90.45  ? 176 ALA C C   1 
ATOM 6772  O O   . ALA C 1 182 ? 3.861   -9.766  45.939  1.00 86.02  ? 176 ALA C O   1 
ATOM 6773  C CB  . ALA C 1 182 ? 3.441   -12.238 47.102  1.00 84.53  ? 176 ALA C CB  1 
ATOM 6774  N N   . CYS C 1 183 ? 1.673   -9.599  45.473  1.00 86.94  ? 177 CYS C N   1 
ATOM 6775  C CA  . CYS C 1 183 ? 1.938   -8.484  44.531  1.00 75.24  ? 177 CYS C CA  1 
ATOM 6776  C C   . CYS C 1 183 ? 2.362   -7.210  45.293  1.00 71.00  ? 177 CYS C C   1 
ATOM 6777  O O   . CYS C 1 183 ? 3.211   -6.488  44.770  1.00 64.80  ? 177 CYS C O   1 
ATOM 6778  C CB  . CYS C 1 183 ? 0.768   -8.292  43.576  1.00 78.88  ? 177 CYS C CB  1 
ATOM 6779  S SG  . CYS C 1 183 ? -0.788  -7.822  44.363  1.00 107.70 ? 177 CYS C SG  1 
ATOM 6780  N N   . LEU C 1 184 ? 1.721   -6.898  46.423  1.00 64.27  ? 178 LEU C N   1 
ATOM 6781  C CA  . LEU C 1 184 ? 1.963   -5.627  47.164  1.00 55.19  ? 178 LEU C CA  1 
ATOM 6782  C C   . LEU C 1 184 ? 3.356   -5.441  47.737  1.00 51.11  ? 178 LEU C C   1 
ATOM 6783  O O   . LEU C 1 184 ? 3.903   -4.352  47.598  1.00 47.36  ? 178 LEU C O   1 
ATOM 6784  C CB  . LEU C 1 184 ? 0.942   -5.602  48.299  1.00 52.94  ? 178 LEU C CB  1 
ATOM 6785  C CG  . LEU C 1 184 ? 0.862   -4.317  49.123  1.00 48.70  ? 178 LEU C CG  1 
ATOM 6786  C CD1 . LEU C 1 184 ? 0.014   -3.299  48.396  1.00 48.29  ? 178 LEU C CD1 1 
ATOM 6787  C CD2 . LEU C 1 184 ? 0.257   -4.644  50.471  1.00 46.21  ? 178 LEU C CD2 1 
ATOM 6788  N N   . LEU C 1 185 ? 3.924   -6.484  48.305  1.00 54.23  ? 179 LEU C N   1 
ATOM 6789  C CA  . LEU C 1 185 ? 5.200   -6.304  49.037  1.00 59.50  ? 179 LEU C CA  1 
ATOM 6790  C C   . LEU C 1 185 ? 6.295   -5.756  48.111  1.00 55.63  ? 179 LEU C C   1 
ATOM 6791  O O   . LEU C 1 185 ? 6.955   -4.779  48.486  1.00 49.04  ? 179 LEU C O   1 
ATOM 6792  C CB  . LEU C 1 185 ? 5.573   -7.633  49.684  1.00 65.52  ? 179 LEU C CB  1 
ATOM 6793  C CG  . LEU C 1 185 ? 4.971   -7.908  51.063  1.00 67.87  ? 179 LEU C CG  1 
ATOM 6794  C CD1 . LEU C 1 185 ? 4.358   -6.658  51.656  1.00 62.17  ? 179 LEU C CD1 1 
ATOM 6795  C CD2 . LEU C 1 185 ? 3.940   -9.006  50.939  1.00 77.44  ? 179 LEU C CD2 1 
ATOM 6796  N N   . PRO C 1 186 ? 6.523   -6.332  46.924  1.00 51.66  ? 180 PRO C N   1 
ATOM 6797  C CA  . PRO C 1 186 ? 7.542   -5.790  46.048  1.00 52.50  ? 180 PRO C CA  1 
ATOM 6798  C C   . PRO C 1 186 ? 7.273   -4.356  45.647  1.00 54.02  ? 180 PRO C C   1 
ATOM 6799  O O   . PRO C 1 186 ? 8.228   -3.601  45.438  1.00 57.88  ? 180 PRO C O   1 
ATOM 6800  C CB  . PRO C 1 186 ? 7.462   -6.751  44.872  1.00 51.56  ? 180 PRO C CB  1 
ATOM 6801  C CG  . PRO C 1 186 ? 6.105   -7.369  44.944  1.00 49.68  ? 180 PRO C CG  1 
ATOM 6802  C CD  . PRO C 1 186 ? 5.901   -7.535  46.420  1.00 51.68  ? 180 PRO C CD  1 
ATOM 6803  N N   . LYS C 1 187 ? 6.010   -3.979  45.543  1.00 54.46  ? 181 LYS C N   1 
ATOM 6804  C CA  . LYS C 1 187 ? 5.594   -2.645  45.134  1.00 57.60  ? 181 LYS C CA  1 
ATOM 6805  C C   . LYS C 1 187 ? 5.895   -1.588  46.201  1.00 60.28  ? 181 LYS C C   1 
ATOM 6806  O O   . LYS C 1 187 ? 6.124   -0.425  45.853  1.00 51.91  ? 181 LYS C O   1 
ATOM 6807  C CB  . LYS C 1 187 ? 4.088   -2.596  44.862  1.00 61.34  ? 181 LYS C CB  1 
ATOM 6808  C CG  . LYS C 1 187 ? 3.622   -3.424  43.685  1.00 67.70  ? 181 LYS C CG  1 
ATOM 6809  C CD  . LYS C 1 187 ? 2.142   -3.200  43.425  1.00 72.77  ? 181 LYS C CD  1 
ATOM 6810  C CE  . LYS C 1 187 ? 1.694   -3.850  42.170  1.00 82.15  ? 181 LYS C CE  1 
ATOM 6811  N NZ  . LYS C 1 187 ? 0.333   -3.418  41.854  1.00 85.93  ? 181 LYS C NZ  1 
ATOM 6812  N N   . LEU C 1 188 ? 5.810   -1.994  47.482  1.00 63.25  ? 182 LEU C N   1 
ATOM 6813  C CA  . LEU C 1 188 ? 6.054   -1.129  48.630  1.00 59.37  ? 182 LEU C CA  1 
ATOM 6814  C C   . LEU C 1 188 ? 7.549   -1.064  48.918  1.00 65.95  ? 182 LEU C C   1 
ATOM 6815  O O   . LEU C 1 188 ? 8.016   -0.151  49.606  1.00 66.85  ? 182 LEU C O   1 
ATOM 6816  C CB  . LEU C 1 188 ? 5.316   -1.664  49.855  1.00 53.04  ? 182 LEU C CB  1 
ATOM 6817  C CG  . LEU C 1 188 ? 3.793   -1.743  49.749  1.00 50.18  ? 182 LEU C CG  1 
ATOM 6818  C CD1 . LEU C 1 188 ? 3.196   -1.793  51.144  1.00 51.31  ? 182 LEU C CD1 1 
ATOM 6819  C CD2 . LEU C 1 188 ? 3.213   -0.588  48.962  1.00 49.10  ? 182 LEU C CD2 1 
ATOM 6820  N N   . ASP C 1 189 ? 8.266   -2.081  48.428  1.00 68.44  ? 183 ASP C N   1 
ATOM 6821  C CA  . ASP C 1 189 ? 9.712   -2.120  48.517  1.00 72.38  ? 183 ASP C CA  1 
ATOM 6822  C C   . ASP C 1 189 ? 10.297  -1.239  47.418  1.00 67.88  ? 183 ASP C C   1 
ATOM 6823  O O   . ASP C 1 189 ? 11.331  -0.610  47.623  1.00 74.64  ? 183 ASP C O   1 
ATOM 6824  C CB  . ASP C 1 189 ? 10.235  -3.549  48.502  1.00 79.46  ? 183 ASP C CB  1 
ATOM 6825  C CG  . ASP C 1 189 ? 9.966   -4.355  49.765  1.00 88.83  ? 183 ASP C CG  1 
ATOM 6826  O OD1 . ASP C 1 189 ? 10.229  -3.815  50.866  1.00 92.61  ? 183 ASP C OD1 1 
ATOM 6827  O OD2 . ASP C 1 189 ? 9.511   -5.522  49.640  1.00 99.52  ? 183 ASP C OD2 1 
ATOM 6828  N N   . GLU C 1 190 ? 9.638   -1.193  46.257  1.00 58.82  ? 184 GLU C N   1 
ATOM 6829  C CA  . GLU C 1 190 ? 10.086  -0.315  45.192  1.00 57.99  ? 184 GLU C CA  1 
ATOM 6830  C C   . GLU C 1 190 ? 9.697   1.119   45.551  1.00 54.68  ? 184 GLU C C   1 
ATOM 6831  O O   . GLU C 1 190 ? 10.508  2.034   45.410  1.00 54.52  ? 184 GLU C O   1 
ATOM 6832  C CB  . GLU C 1 190 ? 9.549   -0.802  43.848  1.00 65.42  ? 184 GLU C CB  1 
ATOM 6833  C CG  . GLU C 1 190 ? 9.967   0.065   42.665  1.00 77.06  ? 184 GLU C CG  1 
ATOM 6834  C CD  . GLU C 1 190 ? 9.430   -0.394  41.316  1.00 97.69  ? 184 GLU C CD  1 
ATOM 6835  O OE1 . GLU C 1 190 ? 8.714   -1.425  41.256  1.00 109.35 ? 184 GLU C OE1 1 
ATOM 6836  O OE2 . GLU C 1 190 ? 9.733   0.295   40.309  1.00 110.95 ? 184 GLU C OE2 1 
ATOM 6837  N N   . LEU C 1 191 ? 8.467   1.310   46.047  1.00 53.82  ? 185 LEU C N   1 
ATOM 6838  C CA  . LEU C 1 191 ? 8.019   2.630   46.462  1.00 53.72  ? 185 LEU C CA  1 
ATOM 6839  C C   . LEU C 1 191 ? 8.972   3.158   47.521  1.00 53.26  ? 185 LEU C C   1 
ATOM 6840  O O   . LEU C 1 191 ? 9.424   4.290   47.400  1.00 59.10  ? 185 LEU C O   1 
ATOM 6841  C CB  . LEU C 1 191 ? 6.582   2.683   46.974  1.00 55.77  ? 185 LEU C CB  1 
ATOM 6842  C CG  . LEU C 1 191 ? 5.485   2.786   45.910  1.00 62.58  ? 185 LEU C CG  1 
ATOM 6843  C CD1 . LEU C 1 191 ? 4.107   2.806   46.556  1.00 64.36  ? 185 LEU C CD1 1 
ATOM 6844  C CD2 . LEU C 1 191 ? 5.646   4.005   45.021  1.00 63.27  ? 185 LEU C CD2 1 
ATOM 6845  N N   . ARG C 1 192 ? 9.277   2.330   48.528  1.00 52.89  ? 186 ARG C N   1 
ATOM 6846  C CA  . ARG C 1 192 ? 10.188  2.712   49.601  1.00 61.36  ? 186 ARG C CA  1 
ATOM 6847  C C   . ARG C 1 192 ? 11.543  3.202   49.070  1.00 68.36  ? 186 ARG C C   1 
ATOM 6848  O O   . ARG C 1 192 ? 12.094  4.160   49.626  1.00 58.31  ? 186 ARG C O   1 
ATOM 6849  C CB  . ARG C 1 192 ? 10.429  1.559   50.585  1.00 61.33  ? 186 ARG C CB  1 
ATOM 6850  C CG  . ARG C 1 192 ? 11.527  1.880   51.591  1.00 65.44  ? 186 ARG C CG  1 
ATOM 6851  C CD  . ARG C 1 192 ? 11.552  0.967   52.800  1.00 69.11  ? 186 ARG C CD  1 
ATOM 6852  N NE  . ARG C 1 192 ? 11.888  -0.413  52.445  1.00 74.91  ? 186 ARG C NE  1 
ATOM 6853  C CZ  . ARG C 1 192 ? 12.087  -1.396  53.317  1.00 86.43  ? 186 ARG C CZ  1 
ATOM 6854  N NH1 . ARG C 1 192 ? 12.204  -1.135  54.610  1.00 87.09  ? 186 ARG C NH1 1 
ATOM 6855  N NH2 . ARG C 1 192 ? 12.195  -2.643  52.883  1.00 92.75  ? 186 ARG C NH2 1 
ATOM 6856  N N   . ASP C 1 193 ? 12.075  2.516   48.033  1.00 76.77  ? 187 ASP C N   1 
ATOM 6857  C CA  . ASP C 1 193 ? 13.410  2.753   47.489  1.00 74.97  ? 187 ASP C CA  1 
ATOM 6858  C C   . ASP C 1 193 ? 13.409  3.966   46.559  1.00 76.04  ? 187 ASP C C   1 
ATOM 6859  O O   . ASP C 1 193 ? 14.401  4.702   46.526  1.00 78.01  ? 187 ASP C O   1 
ATOM 6860  C CB  . ASP C 1 193 ? 13.979  1.529   46.779  1.00 75.35  ? 187 ASP C CB  1 
ATOM 6861  C CG  . ASP C 1 193 ? 14.289  0.317   47.653  1.00 79.69  ? 187 ASP C CG  1 
ATOM 6862  O OD1 . ASP C 1 193 ? 14.631  0.509   48.840  1.00 80.19  ? 187 ASP C OD1 1 
ATOM 6863  O OD2 . ASP C 1 193 ? 14.221  -0.818  47.136  1.00 75.43  ? 187 ASP C OD2 1 
ATOM 6864  N N   . GLU C 1 194 ? 12.307  4.151   45.808  1.00 67.27  ? 188 GLU C N   1 
ATOM 6865  C CA  . GLU C 1 194 ? 12.116  5.318   44.955  1.00 72.69  ? 188 GLU C CA  1 
ATOM 6866  C C   . GLU C 1 194 ? 11.944  6.604   45.782  1.00 70.30  ? 188 GLU C C   1 
ATOM 6867  O O   . GLU C 1 194 ? 12.421  7.671   45.390  1.00 60.22  ? 188 GLU C O   1 
ATOM 6868  C CB  . GLU C 1 194 ? 10.911  5.107   44.036  1.00 82.17  ? 188 GLU C CB  1 
ATOM 6869  C CG  . GLU C 1 194 ? 11.098  4.046   42.952  1.00 85.96  ? 188 GLU C CG  1 
ATOM 6870  C CD  . GLU C 1 194 ? 11.821  4.473   41.682  1.00 97.29  ? 188 GLU C CD  1 
ATOM 6871  O OE1 . GLU C 1 194 ? 12.445  5.559   41.625  1.00 94.45  ? 188 GLU C OE1 1 
ATOM 6872  O OE2 . GLU C 1 194 ? 11.739  3.685   40.714  1.00 109.63 ? 188 GLU C OE2 1 
ATOM 6873  N N   . GLY C 1 195 ? 11.238  6.516   46.917  1.00 72.42  ? 189 GLY C N   1 
ATOM 6874  C CA  . GLY C 1 195 ? 11.113  7.632   47.848  1.00 73.22  ? 189 GLY C CA  1 
ATOM 6875  C C   . GLY C 1 195 ? 12.430  7.963   48.564  1.00 72.65  ? 189 GLY C C   1 
ATOM 6876  O O   . GLY C 1 195 ? 12.690  9.123   48.889  1.00 64.83  ? 189 GLY C O   1 
ATOM 6877  N N   . LYS C 1 196 ? 13.246  6.940   48.847  1.00 70.21  ? 190 LYS C N   1 
ATOM 6878  C CA  . LYS C 1 196 ? 14.580  7.152   49.377  1.00 73.88  ? 190 LYS C CA  1 
ATOM 6879  C C   . LYS C 1 196 ? 15.381  8.025   48.411  1.00 76.20  ? 190 LYS C C   1 
ATOM 6880  O O   . LYS C 1 196 ? 15.992  9.009   48.833  1.00 77.26  ? 190 LYS C O   1 
ATOM 6881  C CB  . LYS C 1 196 ? 15.272  5.804   49.600  1.00 83.12  ? 190 LYS C CB  1 
ATOM 6882  C CG  . LYS C 1 196 ? 14.921  5.110   50.902  1.00 85.04  ? 190 LYS C CG  1 
ATOM 6883  C CD  . LYS C 1 196 ? 15.436  5.835   52.135  1.00 97.89  ? 190 LYS C CD  1 
ATOM 6884  C CE  . LYS C 1 196 ? 16.925  6.043   52.111  1.00 116.32 ? 190 LYS C CE  1 
ATOM 6885  N NZ  . LYS C 1 196 ? 17.449  6.502   53.403  1.00 127.13 ? 190 LYS C NZ  1 
ATOM 6886  N N   . ALA C 1 197 ? 15.356  7.668   47.116  1.00 68.69  ? 191 ALA C N   1 
ATOM 6887  C CA  . ALA C 1 197 ? 16.138  8.356   46.096  1.00 65.56  ? 191 ALA C CA  1 
ATOM 6888  C C   . ALA C 1 197 ? 15.681  9.804   45.882  1.00 62.16  ? 191 ALA C C   1 
ATOM 6889  O O   . ALA C 1 197 ? 16.505  10.716  45.981  1.00 61.05  ? 191 ALA C O   1 
ATOM 6890  C CB  . ALA C 1 197 ? 16.084  7.579   44.803  1.00 68.18  ? 191 ALA C CB  1 
ATOM 6891  N N   . SER C 1 198 ? 14.386  10.016  45.574  1.00 54.92  ? 192 SER C N   1 
ATOM 6892  C CA  . SER C 1 198 ? 13.881  11.346  45.243  1.00 54.99  ? 192 SER C CA  1 
ATOM 6893  C C   . SER C 1 198 ? 14.017  12.298  46.430  1.00 59.46  ? 192 SER C C   1 
ATOM 6894  O O   . SER C 1 198 ? 14.079  13.510  46.234  1.00 57.42  ? 192 SER C O   1 
ATOM 6895  C CB  . SER C 1 198 ? 12.452  11.325  44.782  1.00 54.56  ? 192 SER C CB  1 
ATOM 6896  O OG  . SER C 1 198 ? 11.563  11.476  45.882  1.00 53.75  ? 192 SER C OG  1 
ATOM 6897  N N   . SER C 1 199 ? 13.995  11.739  47.649  1.00 62.01  ? 193 SER C N   1 
ATOM 6898  C CA  . SER C 1 199 ? 14.318  12.480  48.858  1.00 60.87  ? 193 SER C CA  1 
ATOM 6899  C C   . SER C 1 199 ? 15.775  12.928  48.839  1.00 59.95  ? 193 SER C C   1 
ATOM 6900  O O   . SER C 1 199 ? 16.079  14.104  49.036  1.00 57.70  ? 193 SER C O   1 
ATOM 6901  C CB  . SER C 1 199 ? 14.073  11.668  50.087  1.00 61.71  ? 193 SER C CB  1 
ATOM 6902  O OG  . SER C 1 199 ? 14.908  12.142  51.136  1.00 64.88  ? 193 SER C OG  1 
ATOM 6903  N N   . ALA C 1 200 ? 16.677  11.961  48.660  1.00 59.79  ? 194 ALA C N   1 
ATOM 6904  C CA  . ALA C 1 200 ? 18.099  12.237  48.745  1.00 62.33  ? 194 ALA C CA  1 
ATOM 6905  C C   . ALA C 1 200 ? 18.489  13.309  47.733  1.00 63.91  ? 194 ALA C C   1 
ATOM 6906  O O   . ALA C 1 200 ? 19.334  14.156  48.039  1.00 57.64  ? 194 ALA C O   1 
ATOM 6907  C CB  . ALA C 1 200 ? 18.878  10.970  48.519  1.00 64.13  ? 194 ALA C CB  1 
ATOM 6908  N N   . LYS C 1 201 ? 17.853  13.236  46.546  1.00 62.43  ? 195 LYS C N   1 
ATOM 6909  C CA  . LYS C 1 201 ? 18.097  14.141  45.432  1.00 57.44  ? 195 LYS C CA  1 
ATOM 6910  C C   . LYS C 1 201 ? 17.594  15.541  45.743  1.00 57.44  ? 195 LYS C C   1 
ATOM 6911  O O   . LYS C 1 201 ? 18.280  16.520  45.442  1.00 57.17  ? 195 LYS C O   1 
ATOM 6912  C CB  . LYS C 1 201 ? 17.371  13.700  44.161  1.00 54.92  ? 195 LYS C CB  1 
ATOM 6913  C CG  . LYS C 1 201 ? 17.968  12.457  43.539  1.00 57.31  ? 195 LYS C CG  1 
ATOM 6914  C CD  . LYS C 1 201 ? 17.205  11.955  42.329  1.00 54.84  ? 195 LYS C CD  1 
ATOM 6915  C CE  . LYS C 1 201 ? 17.737  10.650  41.882  1.00 56.13  ? 195 LYS C CE  1 
ATOM 6916  N NZ  . LYS C 1 201 ? 16.695  10.052  41.048  1.00 64.96  ? 195 LYS C NZ  1 
ATOM 6917  N N   . GLN C 1 202 ? 16.395  15.608  46.338  1.00 55.39  ? 196 GLN C N   1 
ATOM 6918  C CA  . GLN C 1 202 ? 15.732  16.879  46.591  1.00 52.08  ? 196 GLN C CA  1 
ATOM 6919  C C   . GLN C 1 202 ? 16.443  17.643  47.699  1.00 49.48  ? 196 GLN C C   1 
ATOM 6920  O O   . GLN C 1 202 ? 16.297  18.855  47.770  1.00 47.12  ? 196 GLN C O   1 
ATOM 6921  C CB  . GLN C 1 202 ? 14.257  16.704  46.954  1.00 47.73  ? 196 GLN C CB  1 
ATOM 6922  C CG  . GLN C 1 202 ? 13.414  17.961  46.773  1.00 44.24  ? 196 GLN C CG  1 
ATOM 6923  C CD  . GLN C 1 202 ? 13.538  18.555  45.387  1.00 43.99  ? 196 GLN C CD  1 
ATOM 6924  O OE1 . GLN C 1 202 ? 13.596  17.859  44.360  1.00 42.31  ? 196 GLN C OE1 1 
ATOM 6925  N NE2 . GLN C 1 202 ? 13.634  19.870  45.360  1.00 44.26  ? 196 GLN C NE2 1 
ATOM 6926  N N   . ARG C 1 203 ? 17.177  16.922  48.558  1.00 57.53  ? 197 ARG C N   1 
ATOM 6927  C CA  . ARG C 1 203 ? 18.000  17.523  49.600  1.00 64.98  ? 197 ARG C CA  1 
ATOM 6928  C C   . ARG C 1 203 ? 19.260  18.099  48.963  1.00 58.28  ? 197 ARG C C   1 
ATOM 6929  O O   . ARG C 1 203 ? 19.745  19.145  49.380  1.00 63.27  ? 197 ARG C O   1 
ATOM 6930  C CB  . ARG C 1 203 ? 18.374  16.530  50.713  1.00 69.44  ? 197 ARG C CB  1 
ATOM 6931  C CG  . ARG C 1 203 ? 19.218  17.100  51.848  1.00 75.43  ? 197 ARG C CG  1 
ATOM 6932  C CD  . ARG C 1 203 ? 19.410  16.107  53.002  1.00 84.15  ? 197 ARG C CD  1 
ATOM 6933  N NE  . ARG C 1 203 ? 20.138  16.654  54.159  1.00 95.56  ? 197 ARG C NE  1 
ATOM 6934  C CZ  . ARG C 1 203 ? 19.854  16.513  55.470  1.00 90.65  ? 197 ARG C CZ  1 
ATOM 6935  N NH1 . ARG C 1 203 ? 18.750  15.909  55.887  1.00 85.30  ? 197 ARG C NH1 1 
ATOM 6936  N NH2 . ARG C 1 203 ? 20.693  16.992  56.376  1.00 85.59  ? 197 ARG C NH2 1 
ATOM 6937  N N   . LEU C 1 204 ? 19.809  17.419  47.983  1.00 53.55  ? 198 LEU C N   1 
ATOM 6938  C CA  . LEU C 1 204 ? 21.056  17.973  47.436  1.00 56.37  ? 198 LEU C CA  1 
ATOM 6939  C C   . LEU C 1 204 ? 20.680  19.261  46.722  1.00 53.51  ? 198 LEU C C   1 
ATOM 6940  O O   . LEU C 1 204 ? 21.437  20.228  46.810  1.00 50.87  ? 198 LEU C O   1 
ATOM 6941  C CB  . LEU C 1 204 ? 21.711  16.959  46.507  1.00 59.36  ? 198 LEU C CB  1 
ATOM 6942  C CG  . LEU C 1 204 ? 22.812  16.106  47.140  1.00 65.39  ? 198 LEU C CG  1 
ATOM 6943  C CD1 . LEU C 1 204 ? 23.902  15.813  46.135  1.00 66.77  ? 198 LEU C CD1 1 
ATOM 6944  C CD2 . LEU C 1 204 ? 23.384  16.829  48.341  1.00 71.06  ? 198 LEU C CD2 1 
ATOM 6945  N N   . LYS C 1 205 ? 19.560  19.245  46.020  1.00 57.52  ? 199 LYS C N   1 
ATOM 6946  C CA  . LYS C 1 205 ? 19.170  20.436  45.241  1.00 61.44  ? 199 LYS C CA  1 
ATOM 6947  C C   . LYS C 1 205 ? 18.915  21.645  46.131  1.00 68.82  ? 199 LYS C C   1 
ATOM 6948  O O   . LYS C 1 205 ? 19.357  22.742  45.775  1.00 82.19  ? 199 LYS C O   1 
ATOM 6949  C CB  . LYS C 1 205 ? 17.813  20.180  44.591  1.00 63.96  ? 199 LYS C CB  1 
ATOM 6950  C CG  . LYS C 1 205 ? 17.868  19.384  43.301  1.00 72.67  ? 199 LYS C CG  1 
ATOM 6951  C CD  . LYS C 1 205 ? 16.525  19.220  42.603  1.00 74.19  ? 199 LYS C CD  1 
ATOM 6952  C CE  . LYS C 1 205 ? 16.414  17.878  41.961  1.00 75.39  ? 199 LYS C CE  1 
ATOM 6953  N NZ  . LYS C 1 205 ? 15.892  17.971  40.598  1.00 76.56  ? 199 LYS C NZ  1 
ATOM 6954  N N   . CYS C 1 206 ? 18.175  21.452  47.205  1.00 70.36  ? 200 CYS C N   1 
ATOM 6955  C CA  . CYS C 1 206 ? 17.913  22.569  48.131  1.00 61.95  ? 200 CYS C CA  1 
ATOM 6956  C C   . CYS C 1 206 ? 19.257  23.028  48.658  1.00 56.77  ? 200 CYS C C   1 
ATOM 6957  O O   . CYS C 1 206 ? 19.599  24.191  48.485  1.00 59.84  ? 200 CYS C O   1 
ATOM 6958  C CB  . CYS C 1 206 ? 17.000  22.114  49.258  1.00 63.36  ? 200 CYS C CB  1 
ATOM 6959  S SG  . CYS C 1 206 ? 15.272  22.010  48.744  1.00 71.52  ? 200 CYS C SG  1 
ATOM 6960  N N   . ALA C 1 207 ? 20.005  22.104  49.225  1.00 57.74  ? 201 ALA C N   1 
ATOM 6961  C CA  . ALA C 1 207 ? 21.259  22.524  49.863  1.00 65.96  ? 201 ALA C CA  1 
ATOM 6962  C C   . ALA C 1 207 ? 22.193  23.118  48.829  1.00 73.72  ? 201 ALA C C   1 
ATOM 6963  O O   . ALA C 1 207 ? 22.843  24.133  49.101  1.00 74.41  ? 201 ALA C O   1 
ATOM 6964  C CB  . ALA C 1 207 ? 21.906  21.314  50.445  1.00 66.51  ? 201 ALA C CB  1 
ATOM 6965  N N   . SER C 1 208 ? 22.266  22.505  47.667  1.00 92.95  ? 202 SER C N   1 
ATOM 6966  C CA  . SER C 1 208 ? 23.245  23.076  46.730  1.00 109.03 ? 202 SER C CA  1 
ATOM 6967  C C   . SER C 1 208 ? 22.832  24.503  46.377  1.00 116.68 ? 202 SER C C   1 
ATOM 6968  O O   . SER C 1 208 ? 23.702  25.383  46.337  1.00 111.36 ? 202 SER C O   1 
ATOM 6969  C CB  . SER C 1 208 ? 23.286  22.240  45.506  1.00 107.79 ? 202 SER C CB  1 
ATOM 6970  O OG  . SER C 1 208 ? 21.970  21.899  45.099  1.00 100.04 ? 202 SER C OG  1 
ATOM 6971  N N   . LEU C 1 209 ? 21.546  24.720  46.147  1.00 45.97  ? 203 LEU C N   1 
ATOM 6972  C CA  . LEU C 1 209 ? 21.179  26.079  45.733  1.00 50.12  ? 203 LEU C CA  1 
ATOM 6973  C C   . LEU C 1 209 ? 21.505  27.039  46.863  1.00 57.61  ? 203 LEU C C   1 
ATOM 6974  O O   . LEU C 1 209 ? 22.006  28.136  46.604  1.00 61.68  ? 203 LEU C O   1 
ATOM 6975  C CB  . LEU C 1 209 ? 19.677  25.952  45.503  1.00 50.82  ? 203 LEU C CB  1 
ATOM 6976  C CG  . LEU C 1 209 ? 18.798  27.186  45.711  1.00 51.64  ? 203 LEU C CG  1 
ATOM 6977  C CD1 . LEU C 1 209 ? 17.877  27.289  44.513  1.00 48.67  ? 203 LEU C CD1 1 
ATOM 6978  C CD2 . LEU C 1 209 ? 17.971  27.003  46.967  1.00 56.75  ? 203 LEU C CD2 1 
ATOM 6979  N N   . GLN C 1 210 ? 21.185  26.647  48.084  1.00 67.25  ? 204 GLN C N   1 
ATOM 6980  C CA  . GLN C 1 210 ? 21.440  27.634  49.144  1.00 75.61  ? 204 GLN C CA  1 
ATOM 6981  C C   . GLN C 1 210 ? 22.920  27.962  49.336  1.00 72.03  ? 204 GLN C C   1 
ATOM 6982  O O   . GLN C 1 210 ? 23.218  29.142  49.554  1.00 82.42  ? 204 GLN C O   1 
ATOM 6983  C CB  . GLN C 1 210 ? 20.870  27.012  50.409  1.00 95.07  ? 204 GLN C CB  1 
ATOM 6984  C CG  . GLN C 1 210 ? 19.384  26.684  50.315  1.00 115.11 ? 204 GLN C CG  1 
ATOM 6985  C CD  . GLN C 1 210 ? 18.937  25.621  51.296  1.00 126.44 ? 204 GLN C CD  1 
ATOM 6986  O OE1 . GLN C 1 210 ? 17.741  25.352  51.458  1.00 106.93 ? 204 GLN C OE1 1 
ATOM 6987  N NE2 . GLN C 1 210 ? 19.901  25.009  51.967  1.00 131.56 ? 204 GLN C NE2 1 
ATOM 6988  N N   . LYS C 1 211 ? 23.804  26.965  49.347  1.00 65.87  ? 205 LYS C N   1 
ATOM 6989  C CA  . LYS C 1 211 ? 25.252  27.286  49.428  1.00 71.58  ? 205 LYS C CA  1 
ATOM 6990  C C   . LYS C 1 211 ? 25.851  28.021  48.220  1.00 76.07  ? 205 LYS C C   1 
ATOM 6991  O O   . LYS C 1 211 ? 26.617  28.973  48.437  1.00 83.19  ? 205 LYS C O   1 
ATOM 6992  C CB  . LYS C 1 211 ? 26.012  25.982  49.680  1.00 78.42  ? 205 LYS C CB  1 
ATOM 6993  C CG  . LYS C 1 211 ? 27.507  26.140  49.901  1.00 85.23  ? 205 LYS C CG  1 
ATOM 6994  C CD  . LYS C 1 211 ? 27.939  25.859  51.334  1.00 91.71  ? 205 LYS C CD  1 
ATOM 6995  C CE  . LYS C 1 211 ? 29.412  25.653  51.464  1.00 87.13  ? 205 LYS C CE  1 
ATOM 6996  N NZ  . LYS C 1 211 ? 29.714  24.545  52.371  1.00 86.00  ? 205 LYS C NZ  1 
ATOM 6997  N N   . PHE C 1 212 ? 25.507  27.598  47.002  1.00 78.72  ? 206 PHE C N   1 
ATOM 6998  C CA  . PHE C 1 212 ? 26.158  28.177  45.792  1.00 74.48  ? 206 PHE C CA  1 
ATOM 6999  C C   . PHE C 1 212 ? 25.348  29.248  45.112  1.00 69.26  ? 206 PHE C C   1 
ATOM 7000  O O   . PHE C 1 212 ? 25.854  29.843  44.152  1.00 62.32  ? 206 PHE C O   1 
ATOM 7001  C CB  . PHE C 1 212 ? 26.451  26.915  44.984  1.00 79.48  ? 206 PHE C CB  1 
ATOM 7002  C CG  . PHE C 1 212 ? 27.453  26.011  45.688  1.00 85.23  ? 206 PHE C CG  1 
ATOM 7003  C CD1 . PHE C 1 212 ? 28.739  26.458  45.965  1.00 85.90  ? 206 PHE C CD1 1 
ATOM 7004  C CD2 . PHE C 1 212 ? 27.100  24.733  46.098  1.00 79.83  ? 206 PHE C CD2 1 
ATOM 7005  C CE1 . PHE C 1 212 ? 29.647  25.644  46.619  1.00 82.61  ? 206 PHE C CE1 1 
ATOM 7006  C CE2 . PHE C 1 212 ? 28.013  23.923  46.749  1.00 80.90  ? 206 PHE C CE2 1 
ATOM 7007  C CZ  . PHE C 1 212 ? 29.281  24.381  47.009  1.00 83.49  ? 206 PHE C CZ  1 
ATOM 7008  N N   . GLY C 1 213 ? 24.154  29.515  45.609  1.00 73.77  ? 207 GLY C N   1 
ATOM 7009  C CA  . GLY C 1 213 ? 23.251  30.505  45.003  1.00 71.12  ? 207 GLY C CA  1 
ATOM 7010  C C   . GLY C 1 213 ? 22.417  29.981  43.857  1.00 67.65  ? 207 GLY C C   1 
ATOM 7011  O O   . GLY C 1 213 ? 22.555  28.799  43.518  1.00 63.67  ? 207 GLY C O   1 
ATOM 7012  N N   . GLU C 1 214 ? 21.578  30.841  43.290  1.00 64.67  ? 208 GLU C N   1 
ATOM 7013  C CA  . GLU C 1 214 ? 20.683  30.501  42.159  1.00 58.20  ? 208 GLU C CA  1 
ATOM 7014  C C   . GLU C 1 214 ? 21.449  30.129  40.904  1.00 56.94  ? 208 GLU C C   1 
ATOM 7015  O O   . GLU C 1 214 ? 20.983  29.256  40.168  1.00 56.28  ? 208 GLU C O   1 
ATOM 7016  C CB  . GLU C 1 214 ? 19.761  31.661  41.803  1.00 56.78  ? 208 GLU C CB  1 
ATOM 7017  C CG  . GLU C 1 214 ? 18.354  31.208  41.439  1.00 62.69  ? 208 GLU C CG  1 
ATOM 7018  C CD  . GLU C 1 214 ? 17.318  32.310  41.471  1.00 72.12  ? 208 GLU C CD  1 
ATOM 7019  O OE1 . GLU C 1 214 ? 16.409  32.237  42.319  1.00 73.85  ? 208 GLU C OE1 1 
ATOM 7020  O OE2 . GLU C 1 214 ? 17.422  33.236  40.644  1.00 81.94  ? 208 GLU C OE2 1 
ATOM 7021  N N   . ARG C 1 215 ? 22.537  30.826  40.628  1.00 57.72  ? 209 ARG C N   1 
ATOM 7022  C CA  . ARG C 1 215 ? 23.163  30.623  39.311  1.00 56.81  ? 209 ARG C CA  1 
ATOM 7023  C C   . ARG C 1 215 ? 23.638  29.202  39.129  1.00 55.90  ? 209 ARG C C   1 
ATOM 7024  O O   . ARG C 1 215 ? 23.402  28.651  38.053  1.00 55.66  ? 209 ARG C O   1 
ATOM 7025  C CB  . ARG C 1 215 ? 24.460  31.424  39.304  1.00 58.35  ? 209 ARG C CB  1 
ATOM 7026  C CG  . ARG C 1 215 ? 24.831  32.052  37.970  1.00 54.08  ? 209 ARG C CG  1 
ATOM 7027  C CD  . ARG C 1 215 ? 26.038  32.955  38.117  1.00 52.61  ? 209 ARG C CD  1 
ATOM 7028  N NE  . ARG C 1 215 ? 26.768  33.123  36.859  1.00 50.55  ? 209 ARG C NE  1 
ATOM 7029  C CZ  . ARG C 1 215 ? 28.055  32.864  36.713  1.00 52.60  ? 209 ARG C CZ  1 
ATOM 7030  N NH1 . ARG C 1 215 ? 28.689  32.165  37.633  1.00 52.49  ? 209 ARG C NH1 1 
ATOM 7031  N NH2 . ARG C 1 215 ? 28.702  33.303  35.652  1.00 54.68  ? 209 ARG C NH2 1 
ATOM 7032  N N   . ALA C 1 216 ? 24.238  28.612  40.143  1.00 54.47  ? 210 ALA C N   1 
ATOM 7033  C CA  . ALA C 1 216 ? 24.770  27.263  39.902  1.00 49.88  ? 210 ALA C CA  1 
ATOM 7034  C C   . ALA C 1 216 ? 23.615  26.330  39.582  1.00 45.79  ? 210 ALA C C   1 
ATOM 7035  O O   . ALA C 1 216 ? 23.757  25.477  38.714  1.00 42.75  ? 210 ALA C O   1 
ATOM 7036  C CB  . ALA C 1 216 ? 25.541  26.829  41.095  1.00 52.04  ? 210 ALA C CB  1 
ATOM 7037  N N   . PHE C 1 217 ? 22.513  26.479  40.304  1.00 49.66  ? 211 PHE C N   1 
ATOM 7038  C CA  . PHE C 1 217 ? 21.316  25.651  40.037  1.00 49.47  ? 211 PHE C CA  1 
ATOM 7039  C C   . PHE C 1 217 ? 20.820  25.955  38.672  1.00 50.48  ? 211 PHE C C   1 
ATOM 7040  O O   . PHE C 1 217 ? 20.475  25.033  37.936  1.00 57.57  ? 211 PHE C O   1 
ATOM 7041  C CB  . PHE C 1 217 ? 20.226  25.993  41.047  1.00 50.75  ? 211 PHE C CB  1 
ATOM 7042  C CG  . PHE C 1 217 ? 18.957  25.163  40.934  1.00 53.88  ? 211 PHE C CG  1 
ATOM 7043  C CD1 . PHE C 1 217 ? 18.833  23.958  41.610  1.00 55.93  ? 211 PHE C CD1 1 
ATOM 7044  C CD2 . PHE C 1 217 ? 17.889  25.595  40.159  1.00 51.96  ? 211 PHE C CD2 1 
ATOM 7045  C CE1 . PHE C 1 217 ? 17.676  23.208  41.510  1.00 53.70  ? 211 PHE C CE1 1 
ATOM 7046  C CE2 . PHE C 1 217 ? 16.738  24.837  40.061  1.00 50.70  ? 211 PHE C CE2 1 
ATOM 7047  C CZ  . PHE C 1 217 ? 16.633  23.649  40.736  1.00 51.35  ? 211 PHE C CZ  1 
ATOM 7048  N N   . LYS C 1 218 ? 20.823  27.231  38.318  1.00 50.30  ? 212 LYS C N   1 
ATOM 7049  C CA  . LYS C 1 218 ? 20.323  27.641  36.986  1.00 54.75  ? 212 LYS C CA  1 
ATOM 7050  C C   . LYS C 1 218 ? 21.220  27.014  35.914  1.00 49.01  ? 212 LYS C C   1 
ATOM 7051  O O   . LYS C 1 218 ? 20.700  26.578  34.878  1.00 38.29  ? 212 LYS C O   1 
ATOM 7052  C CB  . LYS C 1 218 ? 20.257  29.170  36.967  1.00 60.61  ? 212 LYS C CB  1 
ATOM 7053  C CG  . LYS C 1 218 ? 18.885  29.799  37.112  1.00 65.32  ? 212 LYS C CG  1 
ATOM 7054  C CD  . LYS C 1 218 ? 18.923  31.308  36.912  1.00 72.45  ? 212 LYS C CD  1 
ATOM 7055  C CE  . LYS C 1 218 ? 17.777  31.811  36.096  1.00 75.62  ? 212 LYS C CE  1 
ATOM 7056  N NZ  . LYS C 1 218 ? 17.502  33.227  36.350  1.00 82.13  ? 212 LYS C NZ  1 
ATOM 7057  N N   . ALA C 1 219 ? 22.526  27.007  36.151  1.00 41.85  ? 213 ALA C N   1 
ATOM 7058  C CA  . ALA C 1 219 ? 23.457  26.357  35.214  1.00 39.84  ? 213 ALA C CA  1 
ATOM 7059  C C   . ALA C 1 219 ? 23.193  24.862  35.131  1.00 45.09  ? 213 ALA C C   1 
ATOM 7060  O O   . ALA C 1 219 ? 23.245  24.287  34.044  1.00 49.51  ? 213 ALA C O   1 
ATOM 7061  C CB  . ALA C 1 219 ? 24.834  26.598  35.713  1.00 37.83  ? 213 ALA C CB  1 
ATOM 7062  N N   . TRP C 1 220 ? 22.939  24.245  36.275  1.00 47.62  ? 214 TRP C N   1 
ATOM 7063  C CA  . TRP C 1 220 ? 22.695  22.795  36.273  1.00 49.32  ? 214 TRP C CA  1 
ATOM 7064  C C   . TRP C 1 220 ? 21.452  22.528  35.478  1.00 53.58  ? 214 TRP C C   1 
ATOM 7065  O O   . TRP C 1 220 ? 21.425  21.589  34.677  1.00 81.57  ? 214 TRP C O   1 
ATOM 7066  C CB  . TRP C 1 220 ? 22.484  22.307  37.708  1.00 49.76  ? 214 TRP C CB  1 
ATOM 7067  C CG  . TRP C 1 220 ? 21.945  20.906  37.826  1.00 46.40  ? 214 TRP C CG  1 
ATOM 7068  C CD1 . TRP C 1 220 ? 22.671  19.761  37.942  1.00 42.80  ? 214 TRP C CD1 1 
ATOM 7069  C CD2 . TRP C 1 220 ? 20.559  20.504  37.849  1.00 47.09  ? 214 TRP C CD2 1 
ATOM 7070  N NE1 . TRP C 1 220 ? 21.842  18.677  38.025  1.00 41.86  ? 214 TRP C NE1 1 
ATOM 7071  C CE2 . TRP C 1 220 ? 20.543  19.100  37.970  1.00 44.50  ? 214 TRP C CE2 1 
ATOM 7072  C CE3 . TRP C 1 220 ? 19.340  21.185  37.778  1.00 50.57  ? 214 TRP C CE3 1 
ATOM 7073  C CZ2 . TRP C 1 220 ? 19.357  18.375  38.018  1.00 52.93  ? 214 TRP C CZ2 1 
ATOM 7074  C CZ3 . TRP C 1 220 ? 18.169  20.466  37.824  1.00 49.58  ? 214 TRP C CZ3 1 
ATOM 7075  C CH2 . TRP C 1 220 ? 18.180  19.080  37.941  1.00 52.75  ? 214 TRP C CH2 1 
ATOM 7076  N N   . ALA C 1 221 ? 20.450  23.361  35.682  1.00 49.43  ? 215 ALA C N   1 
ATOM 7077  C CA  . ALA C 1 221 ? 19.174  23.110  35.000  1.00 53.84  ? 215 ALA C CA  1 
ATOM 7078  C C   . ALA C 1 221 ? 19.383  23.224  33.507  1.00 57.15  ? 215 ALA C C   1 
ATOM 7079  O O   . ALA C 1 221 ? 18.849  22.418  32.741  1.00 61.91  ? 215 ALA C O   1 
ATOM 7080  C CB  . ALA C 1 221 ? 18.163  24.095  35.475  1.00 55.68  ? 215 ALA C CB  1 
ATOM 7081  N N   . VAL C 1 222 ? 20.159  24.218  33.112  1.00 56.29  ? 216 VAL C N   1 
ATOM 7082  C CA  . VAL C 1 222 ? 20.264  24.411  31.653  1.00 61.19  ? 216 VAL C CA  1 
ATOM 7083  C C   . VAL C 1 222 ? 20.901  23.169  31.058  1.00 61.25  ? 216 VAL C C   1 
ATOM 7084  O O   . VAL C 1 222 ? 20.402  22.678  30.040  1.00 68.50  ? 216 VAL C O   1 
ATOM 7085  C CB  . VAL C 1 222 ? 21.180  25.620  31.413  1.00 66.75  ? 216 VAL C CB  1 
ATOM 7086  C CG1 . VAL C 1 222 ? 21.833  25.584  30.039  1.00 70.73  ? 216 VAL C CG1 1 
ATOM 7087  C CG2 . VAL C 1 222 ? 20.465  26.943  31.636  1.00 65.79  ? 216 VAL C CG2 1 
ATOM 7088  N N   . ALA C 1 223 ? 21.932  22.653  31.708  1.00 56.25  ? 217 ALA C N   1 
ATOM 7089  C CA  . ALA C 1 223 ? 22.556  21.506  31.046  1.00 55.73  ? 217 ALA C CA  1 
ATOM 7090  C C   . ALA C 1 223 ? 21.565  20.359  30.973  1.00 59.76  ? 217 ALA C C   1 
ATOM 7091  O O   . ALA C 1 223 ? 21.447  19.726  29.914  1.00 65.34  ? 217 ALA C O   1 
ATOM 7092  C CB  . ALA C 1 223 ? 23.764  21.125  31.838  1.00 53.43  ? 217 ALA C CB  1 
ATOM 7093  N N   . ARG C 1 224 ? 20.854  20.123  32.070  1.00 55.49  ? 218 ARG C N   1 
ATOM 7094  C CA  . ARG C 1 224 ? 19.955  18.955  32.051  1.00 59.60  ? 218 ARG C CA  1 
ATOM 7095  C C   . ARG C 1 224 ? 18.830  19.079  31.038  1.00 52.87  ? 218 ARG C C   1 
ATOM 7096  O O   . ARG C 1 224 ? 18.574  18.120  30.310  1.00 56.32  ? 218 ARG C O   1 
ATOM 7097  C CB  . ARG C 1 224 ? 19.325  18.935  33.443  1.00 68.24  ? 218 ARG C CB  1 
ATOM 7098  C CG  . ARG C 1 224 ? 18.419  17.762  33.786  1.00 73.50  ? 218 ARG C CG  1 
ATOM 7099  C CD  . ARG C 1 224 ? 19.201  16.502  34.110  1.00 80.01  ? 218 ARG C CD  1 
ATOM 7100  N NE  . ARG C 1 224 ? 18.553  15.305  33.564  1.00 96.16  ? 218 ARG C NE  1 
ATOM 7101  C CZ  . ARG C 1 224 ? 18.828  14.740  32.393  1.00 105.27 ? 218 ARG C CZ  1 
ATOM 7102  N NH1 . ARG C 1 224 ? 19.047  15.481  31.323  1.00 88.87  ? 218 ARG C NH1 1 
ATOM 7103  N NH2 . ARG C 1 224 ? 18.875  13.425  32.294  1.00 116.00 ? 218 ARG C NH2 1 
ATOM 7104  N N   . LEU C 1 225 ? 18.215  20.248  30.994  1.00 47.32  ? 219 LEU C N   1 
ATOM 7105  C CA  . LEU C 1 225 ? 17.062  20.439  30.091  1.00 47.87  ? 219 LEU C CA  1 
ATOM 7106  C C   . LEU C 1 225 ? 17.491  20.330  28.633  1.00 48.70  ? 219 LEU C C   1 
ATOM 7107  O O   . LEU C 1 225 ? 16.777  19.735  27.828  1.00 45.08  ? 219 LEU C O   1 
ATOM 7108  C CB  . LEU C 1 225 ? 16.454  21.773  30.494  1.00 48.19  ? 219 LEU C CB  1 
ATOM 7109  C CG  . LEU C 1 225 ? 15.731  21.779  31.842  1.00 48.57  ? 219 LEU C CG  1 
ATOM 7110  C CD1 . LEU C 1 225 ? 14.923  23.045  32.023  1.00 48.42  ? 219 LEU C CD1 1 
ATOM 7111  C CD2 . LEU C 1 225 ? 14.842  20.559  31.938  1.00 49.71  ? 219 LEU C CD2 1 
ATOM 7112  N N   . SER C 1 226 ? 18.633  20.919  28.335  1.00 50.67  ? 220 SER C N   1 
ATOM 7113  C CA  . SER C 1 226 ? 19.152  20.924  26.953  1.00 55.39  ? 220 SER C CA  1 
ATOM 7114  C C   . SER C 1 226 ? 19.465  19.507  26.481  1.00 56.34  ? 220 SER C C   1 
ATOM 7115  O O   . SER C 1 226 ? 19.263  19.236  25.295  1.00 58.11  ? 220 SER C O   1 
ATOM 7116  C CB  . SER C 1 226 ? 20.324  21.813  26.864  1.00 62.71  ? 220 SER C CB  1 
ATOM 7117  O OG  . SER C 1 226 ? 20.122  22.981  27.642  1.00 72.26  ? 220 SER C OG  1 
ATOM 7118  N N   . GLN C 1 227 ? 20.038  18.675  27.344  1.00 49.85  ? 221 GLN C N   1 
ATOM 7119  C CA  . GLN C 1 227 ? 20.256  17.275  26.931  1.00 44.80  ? 221 GLN C CA  1 
ATOM 7120  C C   . GLN C 1 227 ? 18.899  16.640  26.685  1.00 42.53  ? 221 GLN C C   1 
ATOM 7121  O O   . GLN C 1 227 ? 18.756  15.931  25.694  1.00 39.88  ? 221 GLN C O   1 
ATOM 7122  C CB  . GLN C 1 227 ? 20.928  16.538  28.079  1.00 45.71  ? 221 GLN C CB  1 
ATOM 7123  C CG  . GLN C 1 227 ? 22.412  16.814  28.267  1.00 49.15  ? 221 GLN C CG  1 
ATOM 7124  C CD  . GLN C 1 227 ? 23.015  15.956  29.356  1.00 55.25  ? 221 GLN C CD  1 
ATOM 7125  O OE1 . GLN C 1 227 ? 22.318  15.497  30.266  1.00 55.61  ? 221 GLN C OE1 1 
ATOM 7126  N NE2 . GLN C 1 227 ? 24.314  15.718  29.272  1.00 54.23  ? 221 GLN C NE2 1 
ATOM 7127  N N   . ARG C 1 228 ? 17.939  16.922  27.553  1.00 44.08  ? 222 ARG C N   1 
ATOM 7128  C CA  . ARG C 1 228 ? 16.562  16.396  27.411  1.00 51.19  ? 222 ARG C CA  1 
ATOM 7129  C C   . ARG C 1 228 ? 15.912  16.934  26.139  1.00 51.50  ? 222 ARG C C   1 
ATOM 7130  O O   . ARG C 1 228 ? 15.198  16.173  25.477  1.00 50.40  ? 222 ARG C O   1 
ATOM 7131  C CB  . ARG C 1 228 ? 15.758  16.720  28.669  1.00 59.26  ? 222 ARG C CB  1 
ATOM 7132  C CG  . ARG C 1 228 ? 15.970  15.740  29.812  1.00 72.66  ? 222 ARG C CG  1 
ATOM 7133  C CD  . ARG C 1 228 ? 14.897  15.858  30.882  1.00 79.54  ? 222 ARG C CD  1 
ATOM 7134  N NE  . ARG C 1 228 ? 15.384  15.465  32.208  1.00 81.52  ? 222 ARG C NE  1 
ATOM 7135  C CZ  . ARG C 1 228 ? 15.478  14.217  32.648  1.00 98.84  ? 222 ARG C CZ  1 
ATOM 7136  N NH1 . ARG C 1 228 ? 15.371  13.204  31.806  1.00 108.91 ? 222 ARG C NH1 1 
ATOM 7137  N NH2 . ARG C 1 228 ? 15.683  13.982  33.931  1.00 92.88  ? 222 ARG C NH2 1 
ATOM 7138  N N   . PHE C 1 229 ? 16.136  18.206  25.832  1.00 51.43  ? 223 PHE C N   1 
ATOM 7139  C CA  . PHE C 1 229 ? 15.459  18.841  24.675  1.00 53.08  ? 223 PHE C CA  1 
ATOM 7140  C C   . PHE C 1 229 ? 16.495  19.528  23.830  1.00 55.22  ? 223 PHE C C   1 
ATOM 7141  O O   . PHE C 1 229 ? 16.564  20.753  23.799  1.00 60.75  ? 223 PHE C O   1 
ATOM 7142  C CB  . PHE C 1 229 ? 14.415  19.815  25.207  1.00 54.06  ? 223 PHE C CB  1 
ATOM 7143  C CG  . PHE C 1 229 ? 13.593  19.326  26.389  1.00 61.60  ? 223 PHE C CG  1 
ATOM 7144  C CD1 . PHE C 1 229 ? 12.833  18.168  26.300  1.00 69.05  ? 223 PHE C CD1 1 
ATOM 7145  C CD2 . PHE C 1 229 ? 13.574  20.032  27.584  1.00 63.27  ? 223 PHE C CD2 1 
ATOM 7146  C CE1 . PHE C 1 229 ? 12.085  17.727  27.378  1.00 71.92  ? 223 PHE C CE1 1 
ATOM 7147  C CE2 . PHE C 1 229 ? 12.825  19.586  28.657  1.00 63.30  ? 223 PHE C CE2 1 
ATOM 7148  C CZ  . PHE C 1 229 ? 12.083  18.436  28.552  1.00 67.27  ? 223 PHE C CZ  1 
ATOM 7149  N N   . PRO C 1 230 ? 17.297  18.759  23.077  1.00 57.52  ? 224 PRO C N   1 
ATOM 7150  C CA  . PRO C 1 230 ? 18.351  19.303  22.245  1.00 51.74  ? 224 PRO C CA  1 
ATOM 7151  C C   . PRO C 1 230 ? 17.753  20.190  21.189  1.00 52.15  ? 224 PRO C C   1 
ATOM 7152  O O   . PRO C 1 230 ? 18.385  21.182  20.828  1.00 50.63  ? 224 PRO C O   1 
ATOM 7153  C CB  . PRO C 1 230 ? 18.898  18.010  21.685  1.00 54.17  ? 224 PRO C CB  1 
ATOM 7154  C CG  . PRO C 1 230 ? 18.648  16.995  22.749  1.00 55.70  ? 224 PRO C CG  1 
ATOM 7155  C CD  . PRO C 1 230 ? 17.203  17.318  22.997  1.00 59.42  ? 224 PRO C CD  1 
ATOM 7156  N N   . LYS C 1 231 ? 16.618  19.798  20.630  1.00 56.21  ? 225 LYS C N   1 
ATOM 7157  C CA  . LYS C 1 231 ? 15.936  20.523  19.529  1.00 59.04  ? 225 LYS C CA  1 
ATOM 7158  C C   . LYS C 1 231 ? 15.488  21.928  19.935  1.00 55.43  ? 225 LYS C C   1 
ATOM 7159  O O   . LYS C 1 231 ? 15.564  22.832  19.098  1.00 49.86  ? 225 LYS C O   1 
ATOM 7160  C CB  . LYS C 1 231 ? 14.734  19.678  19.107  1.00 62.55  ? 225 LYS C CB  1 
ATOM 7161  C CG  . LYS C 1 231 ? 15.076  18.280  18.622  1.00 68.85  ? 225 LYS C CG  1 
ATOM 7162  C CD  . LYS C 1 231 ? 15.107  18.163  17.105  1.00 74.37  ? 225 LYS C CD  1 
ATOM 7163  C CE  . LYS C 1 231 ? 15.134  16.750  16.622  1.00 74.81  ? 225 LYS C CE  1 
ATOM 7164  N NZ  . LYS C 1 231 ? 13.824  16.112  16.760  1.00 76.67  ? 225 LYS C NZ  1 
ATOM 7165  N N   . ALA C 1 232 ? 15.000  22.098  21.147  1.00 53.07  ? 226 ALA C N   1 
ATOM 7166  C CA  . ALA C 1 232 ? 14.407  23.379  21.576  1.00 52.80  ? 226 ALA C CA  1 
ATOM 7167  C C   . ALA C 1 232 ? 15.401  24.530  21.616  1.00 48.88  ? 226 ALA C C   1 
ATOM 7168  O O   . ALA C 1 232 ? 16.592  24.310  21.837  1.00 40.33  ? 226 ALA C O   1 
ATOM 7169  C CB  . ALA C 1 232 ? 13.739  23.200  22.911  1.00 52.56  ? 226 ALA C CB  1 
ATOM 7170  N N   . GLU C 1 233 ? 14.904  25.720  21.311  1.00 54.19  ? 227 GLU C N   1 
ATOM 7171  C CA  . GLU C 1 233 ? 15.713  26.959  21.279  1.00 62.76  ? 227 GLU C CA  1 
ATOM 7172  C C   . GLU C 1 233 ? 16.168  27.357  22.682  1.00 65.05  ? 227 GLU C C   1 
ATOM 7173  O O   . GLU C 1 233 ? 15.448  27.075  23.642  1.00 69.76  ? 227 GLU C O   1 
ATOM 7174  C CB  . GLU C 1 233 ? 14.865  28.048  20.633  1.00 64.09  ? 227 GLU C CB  1 
ATOM 7175  C CG  . GLU C 1 233 ? 13.642  28.436  21.455  1.00 70.99  ? 227 GLU C CG  1 
ATOM 7176  C CD  . GLU C 1 233 ? 12.382  28.574  20.628  1.00 73.94  ? 227 GLU C CD  1 
ATOM 7177  O OE1 . GLU C 1 233 ? 12.028  27.602  19.938  1.00 72.58  ? 227 GLU C OE1 1 
ATOM 7178  O OE2 . GLU C 1 233 ? 11.757  29.649  20.677  1.00 76.34  ? 227 GLU C OE2 1 
ATOM 7179  N N   . PHE C 1 234 ? 17.304  28.034  22.789  1.00 65.81  ? 228 PHE C N   1 
ATOM 7180  C CA  . PHE C 1 234 ? 17.892  28.350  24.110  1.00 61.07  ? 228 PHE C CA  1 
ATOM 7181  C C   . PHE C 1 234 ? 16.901  29.194  24.821  1.00 56.54  ? 228 PHE C C   1 
ATOM 7182  O O   . PHE C 1 234 ? 16.735  29.067  26.033  1.00 51.87  ? 228 PHE C O   1 
ATOM 7183  C CB  . PHE C 1 234 ? 19.194  29.120  23.897  1.00 56.10  ? 228 PHE C CB  1 
ATOM 7184  C CG  . PHE C 1 234 ? 19.808  29.768  25.126  1.00 47.06  ? 228 PHE C CG  1 
ATOM 7185  C CD1 . PHE C 1 234 ? 20.486  29.009  26.066  1.00 43.45  ? 228 PHE C CD1 1 
ATOM 7186  C CD2 . PHE C 1 234 ? 19.721  31.138  25.322  1.00 48.92  ? 228 PHE C CD2 1 
ATOM 7187  C CE1 . PHE C 1 234 ? 21.043  29.605  27.180  1.00 42.82  ? 228 PHE C CE1 1 
ATOM 7188  C CE2 . PHE C 1 234 ? 20.284  31.727  26.437  1.00 49.42  ? 228 PHE C CE2 1 
ATOM 7189  C CZ  . PHE C 1 234 ? 20.942  30.960  27.362  1.00 45.43  ? 228 PHE C CZ  1 
ATOM 7190  N N   . ALA C 1 235 ? 16.270  30.088  24.092  1.00 54.15  ? 229 ALA C N   1 
ATOM 7191  C CA  . ALA C 1 235 ? 15.347  30.999  24.768  1.00 56.07  ? 229 ALA C CA  1 
ATOM 7192  C C   . ALA C 1 235 ? 14.212  30.203  25.396  1.00 57.32  ? 229 ALA C C   1 
ATOM 7193  O O   . ALA C 1 235 ? 13.840  30.515  26.535  1.00 59.63  ? 229 ALA C O   1 
ATOM 7194  C CB  . ALA C 1 235 ? 14.813  31.927  23.745  1.00 58.95  ? 229 ALA C CB  1 
ATOM 7195  N N   . GLU C 1 236 ? 13.688  29.196  24.713  1.00 56.85  ? 230 GLU C N   1 
ATOM 7196  C CA  . GLU C 1 236 ? 12.630  28.407  25.387  1.00 58.57  ? 230 GLU C CA  1 
ATOM 7197  C C   . GLU C 1 236 ? 13.213  27.717  26.627  1.00 53.56  ? 230 GLU C C   1 
ATOM 7198  O O   . GLU C 1 236 ? 12.546  27.718  27.670  1.00 47.15  ? 230 GLU C O   1 
ATOM 7199  C CB  . GLU C 1 236 ? 11.996  27.454  24.379  1.00 62.33  ? 230 GLU C CB  1 
ATOM 7200  C CG  . GLU C 1 236 ? 10.697  26.817  24.861  1.00 72.24  ? 230 GLU C CG  1 
ATOM 7201  C CD  . GLU C 1 236 ? 9.438   27.608  24.563  1.00 77.11  ? 230 GLU C CD  1 
ATOM 7202  O OE1 . GLU C 1 236 ? 8.856   27.430  23.478  1.00 69.05  ? 230 GLU C OE1 1 
ATOM 7203  O OE2 . GLU C 1 236 ? 9.035   28.401  25.431  1.00 91.59  ? 230 GLU C OE2 1 
ATOM 7204  N N   . VAL C 1 237 ? 14.423  27.182  26.521  1.00 48.02  ? 231 VAL C N   1 
ATOM 7205  C CA  . VAL C 1 237 ? 14.996  26.431  27.667  1.00 50.48  ? 231 VAL C CA  1 
ATOM 7206  C C   . VAL C 1 237 ? 15.184  27.363  28.863  1.00 55.58  ? 231 VAL C C   1 
ATOM 7207  O O   . VAL C 1 237 ? 14.792  26.984  29.976  1.00 52.08  ? 231 VAL C O   1 
ATOM 7208  C CB  . VAL C 1 237 ? 16.344  25.848  27.219  1.00 47.79  ? 231 VAL C CB  1 
ATOM 7209  C CG1 . VAL C 1 237 ? 17.263  25.540  28.394  1.00 44.15  ? 231 VAL C CG1 1 
ATOM 7210  C CG2 . VAL C 1 237 ? 16.162  24.624  26.333  1.00 49.70  ? 231 VAL C CG2 1 
ATOM 7211  N N   . SER C 1 238 ? 15.664  28.574  28.617  1.00 60.45  ? 232 SER C N   1 
ATOM 7212  C CA  . SER C 1 238 ? 15.953  29.521  29.716  1.00 59.36  ? 232 SER C CA  1 
ATOM 7213  C C   . SER C 1 238 ? 14.673  29.875  30.455  1.00 55.20  ? 232 SER C C   1 
ATOM 7214  O O   . SER C 1 238 ? 14.713  29.974  31.680  1.00 54.17  ? 232 SER C O   1 
ATOM 7215  C CB  . SER C 1 238 ? 16.605  30.748  29.183  1.00 63.07  ? 232 SER C CB  1 
ATOM 7216  O OG  . SER C 1 238 ? 17.569  31.243  30.100  1.00 71.44  ? 232 SER C OG  1 
ATOM 7217  N N   . LYS C 1 239 ? 13.591  30.079  29.720  1.00 58.79  ? 233 LYS C N   1 
ATOM 7218  C CA  . LYS C 1 239 ? 12.351  30.501  30.389  1.00 59.99  ? 233 LYS C CA  1 
ATOM 7219  C C   . LYS C 1 239 ? 11.940  29.392  31.325  1.00 54.29  ? 233 LYS C C   1 
ATOM 7220  O O   . LYS C 1 239 ? 11.560  29.666  32.462  1.00 53.07  ? 233 LYS C O   1 
ATOM 7221  C CB  . LYS C 1 239 ? 11.248  30.555  29.342  1.00 67.12  ? 233 LYS C CB  1 
ATOM 7222  C CG  . LYS C 1 239 ? 9.915   31.092  29.828  1.00 74.37  ? 233 LYS C CG  1 
ATOM 7223  C CD  . LYS C 1 239 ? 8.775   30.086  29.750  1.00 79.47  ? 233 LYS C CD  1 
ATOM 7224  C CE  . LYS C 1 239 ? 7.459   30.730  30.034  1.00 83.75  ? 233 LYS C CE  1 
ATOM 7225  N NZ  . LYS C 1 239 ? 6.858   30.233  31.272  1.00 87.55  ? 233 LYS C NZ  1 
ATOM 7226  N N   . LEU C 1 240 ? 12.070  28.171  30.846  1.00 56.68  ? 234 LEU C N   1 
ATOM 7227  C CA  . LEU C 1 240 ? 11.754  27.024  31.713  1.00 58.00  ? 234 LEU C CA  1 
ATOM 7228  C C   . LEU C 1 240 ? 12.721  27.001  32.899  1.00 55.91  ? 234 LEU C C   1 
ATOM 7229  O O   . LEU C 1 240 ? 12.266  26.707  34.003  1.00 60.84  ? 234 LEU C O   1 
ATOM 7230  C CB  . LEU C 1 240 ? 11.837  25.771  30.851  1.00 61.45  ? 234 LEU C CB  1 
ATOM 7231  C CG  . LEU C 1 240 ? 10.965  25.753  29.595  1.00 59.33  ? 234 LEU C CG  1 
ATOM 7232  C CD1 . LEU C 1 240 ? 11.387  24.604  28.706  1.00 54.78  ? 234 LEU C CD1 1 
ATOM 7233  C CD2 . LEU C 1 240 ? 9.513   25.611  29.988  1.00 63.45  ? 234 LEU C CD2 1 
ATOM 7234  N N   . VAL C 1 241 ? 14.003  27.272  32.669  1.00 49.48  ? 235 VAL C N   1 
ATOM 7235  C CA  . VAL C 1 241 ? 14.983  27.182  33.790  1.00 48.04  ? 235 VAL C CA  1 
ATOM 7236  C C   . VAL C 1 241 ? 14.623  28.225  34.853  1.00 51.09  ? 235 VAL C C   1 
ATOM 7237  O O   . VAL C 1 241 ? 14.681  27.894  36.044  1.00 60.90  ? 235 VAL C O   1 
ATOM 7238  C CB  . VAL C 1 241 ? 16.455  27.325  33.371  1.00 47.77  ? 235 VAL C CB  1 
ATOM 7239  C CG1 . VAL C 1 241 ? 17.366  27.603  34.556  1.00 44.06  ? 235 VAL C CG1 1 
ATOM 7240  C CG2 . VAL C 1 241 ? 16.940  26.107  32.600  1.00 52.22  ? 235 VAL C CG2 1 
ATOM 7241  N N   . THR C 1 242 ? 14.250  29.430  34.439  1.00 51.16  ? 236 THR C N   1 
ATOM 7242  C CA  . THR C 1 242 ? 13.871  30.426  35.438  1.00 52.49  ? 236 THR C CA  1 
ATOM 7243  C C   . THR C 1 242 ? 12.652  29.957  36.180  1.00 55.60  ? 236 THR C C   1 
ATOM 7244  O O   . THR C 1 242 ? 12.622  30.091  37.412  1.00 57.30  ? 236 THR C O   1 
ATOM 7245  C CB  . THR C 1 242 ? 13.623  31.734  34.697  1.00 53.61  ? 236 THR C CB  1 
ATOM 7246  O OG1 . THR C 1 242 ? 14.789  31.936  33.908  1.00 56.37  ? 236 THR C OG1 1 
ATOM 7247  C CG2 . THR C 1 242 ? 13.436  32.912  35.633  1.00 56.71  ? 236 THR C CG2 1 
ATOM 7248  N N   . ASP C 1 243 ? 11.683  29.398  35.465  1.00 54.63  ? 237 ASP C N   1 
ATOM 7249  C CA  . ASP C 1 243 ? 10.469  28.845  36.115  1.00 59.07  ? 237 ASP C CA  1 
ATOM 7250  C C   . ASP C 1 243 ? 10.776  27.660  37.034  1.00 58.98  ? 237 ASP C C   1 
ATOM 7251  O O   . ASP C 1 243 ? 10.206  27.610  38.127  1.00 61.75  ? 237 ASP C O   1 
ATOM 7252  C CB  . ASP C 1 243 ? 9.454   28.502  35.044  1.00 62.81  ? 237 ASP C CB  1 
ATOM 7253  C CG  . ASP C 1 243 ? 8.605   29.660  34.545  1.00 70.43  ? 237 ASP C CG  1 
ATOM 7254  O OD1 . ASP C 1 243 ? 8.875   30.804  34.955  1.00 68.36  ? 237 ASP C OD1 1 
ATOM 7255  O OD2 . ASP C 1 243 ? 7.681   29.401  33.751  1.00 75.74  ? 237 ASP C OD2 1 
ATOM 7256  N N   . LEU C 1 244 ? 11.644  26.750  36.609  1.00 58.98  ? 238 LEU C N   1 
ATOM 7257  C CA  . LEU C 1 244 ? 12.050  25.584  37.433  1.00 61.82  ? 238 LEU C CA  1 
ATOM 7258  C C   . LEU C 1 244 ? 12.778  26.043  38.685  1.00 60.58  ? 238 LEU C C   1 
ATOM 7259  O O   . LEU C 1 244 ? 12.566  25.460  39.758  1.00 59.13  ? 238 LEU C O   1 
ATOM 7260  C CB  . LEU C 1 244 ? 12.932  24.646  36.621  1.00 65.36  ? 238 LEU C CB  1 
ATOM 7261  C CG  . LEU C 1 244 ? 13.283  23.310  37.280  1.00 64.97  ? 238 LEU C CG  1 
ATOM 7262  C CD1 . LEU C 1 244 ? 12.032  22.476  37.464  1.00 64.56  ? 238 LEU C CD1 1 
ATOM 7263  C CD2 . LEU C 1 244 ? 14.306  22.562  36.451  1.00 62.19  ? 238 LEU C CD2 1 
ATOM 7264  N N   . THR C 1 245 ? 13.631  27.039  38.531  1.00 53.90  ? 239 THR C N   1 
ATOM 7265  C CA  . THR C 1 245 ? 14.433  27.441  39.685  1.00 61.68  ? 239 THR C CA  1 
ATOM 7266  C C   . THR C 1 245 ? 13.503  27.936  40.752  1.00 55.90  ? 239 THR C C   1 
ATOM 7267  O O   . THR C 1 245 ? 13.752  27.653  41.927  1.00 46.30  ? 239 THR C O   1 
ATOM 7268  C CB  . THR C 1 245 ? 15.461  28.473  39.244  1.00 69.10  ? 239 THR C CB  1 
ATOM 7269  O OG1 . THR C 1 245 ? 16.119  27.851  38.149  1.00 70.43  ? 239 THR C OG1 1 
ATOM 7270  C CG2 . THR C 1 245 ? 16.480  28.773  40.324  1.00 68.43  ? 239 THR C CG2 1 
ATOM 7271  N N   . LYS C 1 246 ? 12.481  28.682  40.356  1.00 58.83  ? 240 LYS C N   1 
ATOM 7272  C CA  . LYS C 1 246 ? 11.523  29.234  41.341  1.00 62.57  ? 240 LYS C CA  1 
ATOM 7273  C C   . LYS C 1 246 ? 10.771  28.139  42.079  1.00 54.49  ? 240 LYS C C   1 
ATOM 7274  O O   . LYS C 1 246 ? 10.625  28.263  43.296  1.00 50.55  ? 240 LYS C O   1 
ATOM 7275  C CB  . LYS C 1 246 ? 10.434  29.998  40.592  1.00 68.19  ? 240 LYS C CB  1 
ATOM 7276  C CG  . LYS C 1 246 ? 9.748   31.147  41.306  1.00 72.78  ? 240 LYS C CG  1 
ATOM 7277  C CD  . LYS C 1 246 ? 8.523   31.617  40.530  1.00 77.36  ? 240 LYS C CD  1 
ATOM 7278  C CE  . LYS C 1 246 ? 7.572   32.435  41.346  1.00 78.33  ? 240 LYS C CE  1 
ATOM 7279  N NZ  . LYS C 1 246 ? 6.283   32.621  40.676  1.00 76.89  ? 240 LYS C NZ  1 
ATOM 7280  N N   . VAL C 1 247 ? 10.340  27.097  41.378  1.00 49.25  ? 241 VAL C N   1 
ATOM 7281  C CA  . VAL C 1 247 ? 9.519   26.105  42.114  1.00 45.28  ? 241 VAL C CA  1 
ATOM 7282  C C   . VAL C 1 247 ? 10.391  25.495  43.199  1.00 42.44  ? 241 VAL C C   1 
ATOM 7283  O O   . VAL C 1 247 ? 9.957   25.431  44.344  1.00 39.02  ? 241 VAL C O   1 
ATOM 7284  C CB  . VAL C 1 247 ? 9.082   25.037  41.099  1.00 41.05  ? 241 VAL C CB  1 
ATOM 7285  C CG1 . VAL C 1 247 ? 8.736   23.715  41.764  1.00 42.27  ? 241 VAL C CG1 1 
ATOM 7286  C CG2 . VAL C 1 247 ? 7.938   25.520  40.223  1.00 38.57  ? 241 VAL C CG2 1 
ATOM 7287  N N   . HIS C 1 248 ? 11.623  25.176  42.845  1.00 46.03  ? 242 HIS C N   1 
ATOM 7288  C CA  . HIS C 1 248 ? 12.576  24.597  43.821  1.00 48.91  ? 242 HIS C CA  1 
ATOM 7289  C C   . HIS C 1 248 ? 12.923  25.565  44.955  1.00 49.73  ? 242 HIS C C   1 
ATOM 7290  O O   . HIS C 1 248 ? 13.023  25.123  46.105  1.00 56.27  ? 242 HIS C O   1 
ATOM 7291  C CB  . HIS C 1 248 ? 13.740  23.984  43.043  1.00 48.79  ? 242 HIS C CB  1 
ATOM 7292  C CG  . HIS C 1 248 ? 13.360  22.710  42.370  1.00 50.44  ? 242 HIS C CG  1 
ATOM 7293  N ND1 . HIS C 1 248 ? 13.212  21.531  43.063  1.00 47.41  ? 242 HIS C ND1 1 
ATOM 7294  C CD2 . HIS C 1 248 ? 13.080  22.426  41.100  1.00 53.15  ? 242 HIS C CD2 1 
ATOM 7295  C CE1 . HIS C 1 248 ? 12.867  20.572  42.224  1.00 48.49  ? 242 HIS C CE1 1 
ATOM 7296  N NE2 . HIS C 1 248 ? 12.781  21.093  41.027  1.00 51.97  ? 242 HIS C NE2 1 
ATOM 7297  N N   . THR C 1 249 ? 13.134  26.836  44.651  1.00 52.51  ? 243 THR C N   1 
ATOM 7298  C CA  . THR C 1 249 ? 13.555  27.749  45.722  1.00 53.68  ? 243 THR C CA  1 
ATOM 7299  C C   . THR C 1 249 ? 12.476  27.851  46.751  1.00 54.81  ? 243 THR C C   1 
ATOM 7300  O O   . THR C 1 249 ? 12.792  27.858  47.944  1.00 56.35  ? 243 THR C O   1 
ATOM 7301  C CB  . THR C 1 249 ? 13.860  29.115  45.127  1.00 52.40  ? 243 THR C CB  1 
ATOM 7302  O OG1 . THR C 1 249 ? 14.569  28.851  43.923  1.00 61.26  ? 243 THR C OG1 1 
ATOM 7303  C CG2 . THR C 1 249 ? 14.719  29.967  46.040  1.00 53.91  ? 243 THR C CG2 1 
ATOM 7304  N N   . GLU C 1 250 ? 11.232  27.941  46.300  1.00 54.97  ? 244 GLU C N   1 
ATOM 7305  C CA  . GLU C 1 250 ? 10.108  27.984  47.251  1.00 55.51  ? 244 GLU C CA  1 
ATOM 7306  C C   . GLU C 1 250 ? 10.029  26.684  48.037  1.00 53.08  ? 244 GLU C C   1 
ATOM 7307  O O   . GLU C 1 250 ? 9.818   26.733  49.252  1.00 54.36  ? 244 GLU C O   1 
ATOM 7308  C CB  . GLU C 1 250 ? 8.831   28.161  46.438  1.00 57.79  ? 244 GLU C CB  1 
ATOM 7309  C CG  . GLU C 1 250 ? 8.780   29.459  45.641  1.00 57.07  ? 244 GLU C CG  1 
ATOM 7310  C CD  . GLU C 1 250 ? 7.648   29.463  44.632  1.00 55.84  ? 244 GLU C CD  1 
ATOM 7311  O OE1 . GLU C 1 250 ? 7.097   28.383  44.364  1.00 59.70  ? 244 GLU C OE1 1 
ATOM 7312  O OE2 . GLU C 1 250 ? 7.317   30.543  44.119  1.00 50.55  ? 244 GLU C OE2 1 
ATOM 7313  N N   . CYS C 1 251 ? 10.221  25.565  47.359  1.00 51.40  ? 245 CYS C N   1 
ATOM 7314  C CA  . CYS C 1 251 ? 10.066  24.256  48.026  1.00 49.41  ? 245 CYS C CA  1 
ATOM 7315  C C   . CYS C 1 251 ? 11.123  24.149  49.115  1.00 47.61  ? 245 CYS C C   1 
ATOM 7316  O O   . CYS C 1 251 ? 10.810  23.607  50.173  1.00 44.91  ? 245 CYS C O   1 
ATOM 7317  C CB  . CYS C 1 251 ? 10.126  23.144  46.987  1.00 50.82  ? 245 CYS C CB  1 
ATOM 7318  S SG  . CYS C 1 251 ? 8.504   22.560  46.437  1.00 48.35  ? 245 CYS C SG  1 
ATOM 7319  N N   . CYS C 1 252 ? 12.335  24.599  48.823  1.00 46.35  ? 246 CYS C N   1 
ATOM 7320  C CA  . CYS C 1 252 ? 13.447  24.612  49.808  1.00 49.86  ? 246 CYS C CA  1 
ATOM 7321  C C   . CYS C 1 252 ? 13.086  25.549  50.965  1.00 46.99  ? 246 CYS C C   1 
ATOM 7322  O O   . CYS C 1 252 ? 13.355  25.180  52.107  1.00 41.43  ? 246 CYS C O   1 
ATOM 7323  C CB  . CYS C 1 252 ? 14.721  24.925  49.035  1.00 55.65  ? 246 CYS C CB  1 
ATOM 7324  S SG  . CYS C 1 252 ? 15.040  23.728  47.718  1.00 57.01  ? 246 CYS C SG  1 
ATOM 7325  N N   . HIS C 1 253 ? 12.483  26.687  50.661  1.00 54.97  ? 247 HIS C N   1 
ATOM 7326  C CA  . HIS C 1 253 ? 11.986  27.708  51.630  1.00 59.05  ? 247 HIS C CA  1 
ATOM 7327  C C   . HIS C 1 253 ? 10.850  27.078  52.438  1.00 55.07  ? 247 HIS C C   1 
ATOM 7328  O O   . HIS C 1 253 ? 10.506  27.600  53.496  1.00 58.62  ? 247 HIS C O   1 
ATOM 7329  C CB  . HIS C 1 253 ? 11.836  29.074  50.957  1.00 68.03  ? 247 HIS C CB  1 
ATOM 7330  C CG  . HIS C 1 253 ? 13.176  29.701  50.761  1.00 83.19  ? 247 HIS C CG  1 
ATOM 7331  N ND1 . HIS C 1 253 ? 13.420  30.842  50.030  1.00 91.21  ? 247 HIS C ND1 1 
ATOM 7332  C CD2 . HIS C 1 253 ? 14.369  29.304  51.224  1.00 90.35  ? 247 HIS C CD2 1 
ATOM 7333  C CE1 . HIS C 1 253 ? 14.718  31.114  50.061  1.00 91.86  ? 247 HIS C CE1 1 
ATOM 7334  N NE2 . HIS C 1 253 ? 15.313  30.192  50.779  1.00 89.84  ? 247 HIS C NE2 1 
ATOM 7335  N N   . GLY C 1 254 ? 10.199  26.068  51.886  1.00 59.24  ? 248 GLY C N   1 
ATOM 7336  C CA  . GLY C 1 254 ? 9.039   25.472  52.554  1.00 66.25  ? 248 GLY C CA  1 
ATOM 7337  C C   . GLY C 1 254 ? 7.762   26.137  52.168  1.00 69.01  ? 248 GLY C C   1 
ATOM 7338  O O   . GLY C 1 254 ? 6.732   25.797  52.760  1.00 73.33  ? 248 GLY C O   1 
ATOM 7339  N N   . ASP C 1 255 ? 7.804   27.031  51.188  1.00 76.79  ? 249 ASP C N   1 
ATOM 7340  C CA  . ASP C 1 255 ? 6.486   27.605  50.835  1.00 81.82  ? 249 ASP C CA  1 
ATOM 7341  C C   . ASP C 1 255 ? 5.557   26.486  50.336  1.00 84.40  ? 249 ASP C C   1 
ATOM 7342  O O   . ASP C 1 255 ? 4.393   26.515  50.771  1.00 91.75  ? 249 ASP C O   1 
ATOM 7343  C CB  . ASP C 1 255 ? 6.766   28.741  49.871  1.00 76.07  ? 249 ASP C CB  1 
ATOM 7344  C CG  . ASP C 1 255 ? 7.704   29.811  50.402  1.00 76.30  ? 249 ASP C CG  1 
ATOM 7345  O OD1 . ASP C 1 255 ? 8.877   29.486  50.623  1.00 81.90  ? 249 ASP C OD1 1 
ATOM 7346  O OD2 . ASP C 1 255 ? 7.246   30.948  50.617  1.00 67.34  ? 249 ASP C OD2 1 
ATOM 7347  N N   . LEU C 1 256 ? 5.976   25.546  49.493  1.00 78.22  ? 250 LEU C N   1 
ATOM 7348  C CA  . LEU C 1 256 ? 5.252   24.270  49.206  1.00 80.28  ? 250 LEU C CA  1 
ATOM 7349  C C   . LEU C 1 256 ? 3.948   24.388  48.407  1.00 76.46  ? 250 LEU C C   1 
ATOM 7350  O O   . LEU C 1 256 ? 3.865   23.795  47.326  1.00 90.64  ? 250 LEU C O   1 
ATOM 7351  C CB  . LEU C 1 256 ? 5.006   23.531  50.516  1.00 30.00  ? 250 LEU C CB  1 
ATOM 7352  C CG  . LEU C 1 256 ? 5.860   22.283  50.751  1.00 30.00  ? 250 LEU C CG  1 
ATOM 7353  C CD1 . LEU C 1 256 ? 7.337   22.621  50.697  1.00 30.00  ? 250 LEU C CD1 1 
ATOM 7354  C CD2 . LEU C 1 256 ? 5.516   21.611  52.061  1.00 30.00  ? 250 LEU C CD2 1 
ATOM 7355  N N   . LEU C 1 257 ? 2.978   25.125  48.932  1.00 65.55  ? 251 LEU C N   1 
ATOM 7356  C CA  . LEU C 1 257 ? 1.678   25.257  48.239  1.00 65.65  ? 251 LEU C CA  1 
ATOM 7357  C C   . LEU C 1 257 ? 1.948   25.956  46.918  1.00 67.85  ? 251 LEU C C   1 
ATOM 7358  O O   . LEU C 1 257 ? 1.347   25.596  45.902  1.00 58.50  ? 251 LEU C O   1 
ATOM 7359  C CB  . LEU C 1 257 ? 0.762   26.064  49.147  1.00 30.00  ? 251 LEU C CB  1 
ATOM 7360  C CG  . LEU C 1 257 ? 0.252   25.365  50.409  1.00 30.00  ? 251 LEU C CG  1 
ATOM 7361  C CD1 . LEU C 1 257 ? -0.207  26.426  51.377  1.00 30.00  ? 251 LEU C CD1 1 
ATOM 7362  C CD2 . LEU C 1 257 ? -0.893  24.428  50.097  1.00 30.00  ? 251 LEU C CD2 1 
ATOM 7363  N N   . GLU C 1 258 ? 2.811   26.958  46.966  1.00 72.93  ? 252 GLU C N   1 
ATOM 7364  C CA  . GLU C 1 258 ? 3.240   27.679  45.752  1.00 74.67  ? 252 GLU C CA  1 
ATOM 7365  C C   . GLU C 1 258 ? 3.997   26.768  44.784  1.00 73.09  ? 252 GLU C C   1 
ATOM 7366  O O   . GLU C 1 258 ? 3.692   26.834  43.586  1.00 82.87  ? 252 GLU C O   1 
ATOM 7367  C CB  . GLU C 1 258 ? 4.070   28.831  46.302  1.00 80.88  ? 252 GLU C CB  1 
ATOM 7368  C CG  . GLU C 1 258 ? 4.348   28.672  47.791  1.00 80.65  ? 252 GLU C CG  1 
ATOM 7369  C CD  . GLU C 1 258 ? 3.739   29.727  48.688  1.00 83.08  ? 252 GLU C CD  1 
ATOM 7370  O OE1 . GLU C 1 258 ? 3.386   29.387  49.832  1.00 76.04  ? 252 GLU C OE1 1 
ATOM 7371  O OE2 . GLU C 1 258 ? 3.636   30.887  48.248  1.00 85.51  ? 252 GLU C OE2 1 
ATOM 7372  N N   . CYS C 1 259 ? 4.877   25.890  45.268  1.00 63.69  ? 253 CYS C N   1 
ATOM 7373  C CA  . CYS C 1 259 ? 5.663   25.110  44.293  1.00 61.87  ? 253 CYS C CA  1 
ATOM 7374  C C   . CYS C 1 259 ? 4.673   24.286  43.501  1.00 59.83  ? 253 CYS C C   1 
ATOM 7375  O O   . CYS C 1 259 ? 4.793   24.209  42.275  1.00 58.53  ? 253 CYS C O   1 
ATOM 7376  C CB  . CYS C 1 259 ? 6.386   23.921  44.891  1.00 60.68  ? 253 CYS C CB  1 
ATOM 7377  S SG  . CYS C 1 259 ? 7.440   24.263  46.313  1.00 91.14  ? 253 CYS C SG  1 
ATOM 7378  N N   . ALA C 1 260 ? 3.692   23.743  44.195  1.00 56.61  ? 254 ALA C N   1 
ATOM 7379  C CA  . ALA C 1 260 ? 2.730   22.866  43.519  1.00 58.17  ? 254 ALA C CA  1 
ATOM 7380  C C   . ALA C 1 260 ? 2.000   23.666  42.452  1.00 62.98  ? 254 ALA C C   1 
ATOM 7381  O O   . ALA C 1 260 ? 1.894   23.188  41.320  1.00 79.57  ? 254 ALA C O   1 
ATOM 7382  C CB  . ALA C 1 260 ? 1.795   22.333  44.545  1.00 59.08  ? 254 ALA C CB  1 
ATOM 7383  N N   . ASP C 1 261 ? 1.522   24.851  42.803  1.00 59.97  ? 255 ASP C N   1 
ATOM 7384  C CA  . ASP C 1 261 ? 0.754   25.675  41.844  1.00 57.94  ? 255 ASP C CA  1 
ATOM 7385  C C   . ASP C 1 261 ? 1.675   26.008  40.688  1.00 57.22  ? 255 ASP C C   1 
ATOM 7386  O O   . ASP C 1 261 ? 1.239   25.938  39.540  1.00 52.91  ? 255 ASP C O   1 
ATOM 7387  C CB  . ASP C 1 261 ? 0.270   26.958  42.479  1.00 56.54  ? 255 ASP C CB  1 
ATOM 7388  C CG  . ASP C 1 261 ? -1.162  27.350  42.178  1.00 57.15  ? 255 ASP C CG  1 
ATOM 7389  O OD1 . ASP C 1 261 ? -1.730  26.787  41.228  1.00 65.56  ? 255 ASP C OD1 1 
ATOM 7390  O OD2 . ASP C 1 261 ? -1.679  28.217  42.900  1.00 55.12  ? 255 ASP C OD2 1 
ATOM 7391  N N   . ASP C 1 262 ? 2.926   26.305  40.998  1.00 56.83  ? 256 ASP C N   1 
ATOM 7392  C CA  . ASP C 1 262 ? 3.823   26.756  39.949  1.00 62.05  ? 256 ASP C CA  1 
ATOM 7393  C C   . ASP C 1 262 ? 4.302   25.584  39.098  1.00 70.40  ? 256 ASP C C   1 
ATOM 7394  O O   . ASP C 1 262 ? 4.337   25.702  37.871  1.00 88.37  ? 256 ASP C O   1 
ATOM 7395  C CB  . ASP C 1 262 ? 4.990   27.535  40.530  1.00 61.24  ? 256 ASP C CB  1 
ATOM 7396  C CG  . ASP C 1 262 ? 4.616   28.856  41.190  1.00 60.10  ? 256 ASP C CG  1 
ATOM 7397  O OD1 . ASP C 1 262 ? 3.474   29.317  40.996  1.00 59.56  ? 256 ASP C OD1 1 
ATOM 7398  O OD2 . ASP C 1 262 ? 5.467   29.407  41.911  1.00 60.14  ? 256 ASP C OD2 1 
ATOM 7399  N N   . ARG C 1 263 ? 4.688   24.476  39.748  1.00 62.75  ? 257 ARG C N   1 
ATOM 7400  C CA  . ARG C 1 263 ? 5.050   23.266  39.029  1.00 58.61  ? 257 ARG C CA  1 
ATOM 7401  C C   . ARG C 1 263 ? 3.907   22.879  38.102  1.00 54.55  ? 257 ARG C C   1 
ATOM 7402  O O   . ARG C 1 263 ? 4.157   22.644  36.933  1.00 59.13  ? 257 ARG C O   1 
ATOM 7403  C CB  . ARG C 1 263 ? 5.361   22.078  39.938  1.00 62.71  ? 257 ARG C CB  1 
ATOM 7404  C CG  . ARG C 1 263 ? 5.693   20.784  39.210  1.00 67.59  ? 257 ARG C CG  1 
ATOM 7405  C CD  . ARG C 1 263 ? 5.676   19.635  40.194  1.00 73.85  ? 257 ARG C CD  1 
ATOM 7406  N NE  . ARG C 1 263 ? 6.528   18.523  39.759  1.00 85.74  ? 257 ARG C NE  1 
ATOM 7407  C CZ  . ARG C 1 263 ? 6.183   17.245  39.764  1.00 94.74  ? 257 ARG C CZ  1 
ATOM 7408  N NH1 . ARG C 1 263 ? 4.945   16.900  40.085  1.00 102.43 ? 257 ARG C NH1 1 
ATOM 7409  N NH2 . ARG C 1 263 ? 7.079   16.322  39.446  1.00 91.66  ? 257 ARG C NH2 1 
ATOM 7410  N N   . ALA C 1 264 ? 2.667   22.857  38.619  1.00 53.54  ? 258 ALA C N   1 
ATOM 7411  C CA  . ALA C 1 264 ? 1.487   22.566  37.812  1.00 54.75  ? 258 ALA C CA  1 
ATOM 7412  C C   . ALA C 1 264 ? 1.409   23.495  36.594  1.00 59.43  ? 258 ALA C C   1 
ATOM 7413  O O   . ALA C 1 264 ? 0.976   23.093  35.515  1.00 61.83  ? 258 ALA C O   1 
ATOM 7414  C CB  . ALA C 1 264 ? 0.244   22.669  38.667  1.00 50.87  ? 258 ALA C CB  1 
ATOM 7415  N N   . ASP C 1 265 ? 1.853   24.743  36.769  1.00 59.40  ? 259 ASP C N   1 
ATOM 7416  C CA  . ASP C 1 265 ? 1.860   25.722  35.698  1.00 57.07  ? 259 ASP C CA  1 
ATOM 7417  C C   . ASP C 1 265 ? 2.969   25.412  34.683  1.00 55.83  ? 259 ASP C C   1 
ATOM 7418  O O   . ASP C 1 265 ? 2.793   25.664  33.495  1.00 60.32  ? 259 ASP C O   1 
ATOM 7419  C CB  . ASP C 1 265 ? 1.798   27.115  36.307  1.00 57.60  ? 259 ASP C CB  1 
ATOM 7420  C CG  . ASP C 1 265 ? 0.460   27.442  36.969  1.00 65.64  ? 259 ASP C CG  1 
ATOM 7421  O OD1 . ASP C 1 265 ? -0.481  26.626  36.812  1.00 69.79  ? 259 ASP C OD1 1 
ATOM 7422  O OD2 . ASP C 1 265 ? 0.353   28.501  37.648  1.00 65.45  ? 259 ASP C OD2 1 
ATOM 7423  N N   . LEU C 1 266 ? 4.104   24.849  35.116  1.00 51.60  ? 260 LEU C N   1 
ATOM 7424  C CA  . LEU C 1 266 ? 5.117   24.403  34.171  1.00 51.93  ? 260 LEU C CA  1 
ATOM 7425  C C   . LEU C 1 266 ? 4.530   23.345  33.235  1.00 58.82  ? 260 LEU C C   1 
ATOM 7426  O O   . LEU C 1 266 ? 4.460   23.558  32.030  1.00 68.25  ? 260 LEU C O   1 
ATOM 7427  C CB  . LEU C 1 266 ? 6.378   23.872  34.855  1.00 50.82  ? 260 LEU C CB  1 
ATOM 7428  C CG  . LEU C 1 266 ? 7.598   24.792  34.829  1.00 52.28  ? 260 LEU C CG  1 
ATOM 7429  C CD1 . LEU C 1 266 ? 8.853   24.049  35.275  1.00 47.96  ? 260 LEU C CD1 1 
ATOM 7430  C CD2 . LEU C 1 266 ? 7.785   25.418  33.442  1.00 55.14  ? 260 LEU C CD2 1 
ATOM 7431  N N   . ALA C 1 267 ? 4.141   22.191  33.788  1.00 55.29  ? 261 ALA C N   1 
ATOM 7432  C CA  . ALA C 1 267 ? 3.589   21.111  32.997  1.00 51.34  ? 261 ALA C CA  1 
ATOM 7433  C C   . ALA C 1 267 ? 2.506   21.669  32.080  1.00 48.42  ? 261 ALA C C   1 
ATOM 7434  O O   . ALA C 1 267 ? 2.532   21.432  30.885  1.00 51.89  ? 261 ALA C O   1 
ATOM 7435  C CB  . ALA C 1 267 ? 3.056   20.039  33.911  1.00 58.71  ? 261 ALA C CB  1 
ATOM 7436  N N   . LYS C 1 268 ? 1.576   22.445  32.636  1.00 49.49  ? 262 LYS C N   1 
ATOM 7437  C CA  . LYS C 1 268 ? 0.552   23.096  31.834  1.00 55.09  ? 262 LYS C CA  1 
ATOM 7438  C C   . LYS C 1 268 ? 1.195   23.727  30.598  1.00 55.70  ? 262 LYS C C   1 
ATOM 7439  O O   . LYS C 1 268 ? 0.791   23.445  29.472  1.00 54.16  ? 262 LYS C O   1 
ATOM 7440  C CB  . LYS C 1 268 ? -0.180  24.122  32.712  1.00 64.41  ? 262 LYS C CB  1 
ATOM 7441  C CG  . LYS C 1 268 ? -1.323  24.909  32.068  1.00 73.50  ? 262 LYS C CG  1 
ATOM 7442  C CD  . LYS C 1 268 ? -2.675  24.203  32.023  1.00 82.36  ? 262 LYS C CD  1 
ATOM 7443  C CE  . LYS C 1 268 ? -3.813  25.164  31.831  1.00 89.65  ? 262 LYS C CE  1 
ATOM 7444  N NZ  . LYS C 1 268 ? -3.679  25.922  30.584  1.00 97.54  ? 262 LYS C NZ  1 
ATOM 7445  N N   . TYR C 1 269 ? 2.211   24.571  30.834  1.00 62.65  ? 263 TYR C N   1 
ATOM 7446  C CA  . TYR C 1 269 ? 2.919   25.322  29.801  1.00 62.45  ? 263 TYR C CA  1 
ATOM 7447  C C   . TYR C 1 269 ? 3.603   24.391  28.792  1.00 64.84  ? 263 TYR C C   1 
ATOM 7448  O O   . TYR C 1 269 ? 3.472   24.553  27.579  1.00 64.03  ? 263 TYR C O   1 
ATOM 7449  C CB  . TYR C 1 269 ? 3.955   26.230  30.476  1.00 59.14  ? 263 TYR C CB  1 
ATOM 7450  C CG  . TYR C 1 269 ? 4.822   26.987  29.484  1.00 63.83  ? 263 TYR C CG  1 
ATOM 7451  C CD1 . TYR C 1 269 ? 4.343   28.135  28.861  1.00 67.94  ? 263 TYR C CD1 1 
ATOM 7452  C CD2 . TYR C 1 269 ? 6.097   26.543  29.150  1.00 72.49  ? 263 TYR C CD2 1 
ATOM 7453  C CE1 . TYR C 1 269 ? 5.106   28.824  27.935  1.00 73.92  ? 263 TYR C CE1 1 
ATOM 7454  C CE2 . TYR C 1 269 ? 6.875   27.228  28.226  1.00 79.51  ? 263 TYR C CE2 1 
ATOM 7455  C CZ  . TYR C 1 269 ? 6.374   28.370  27.619  1.00 81.33  ? 263 TYR C CZ  1 
ATOM 7456  O OH  . TYR C 1 269 ? 7.099   29.080  26.710  1.00 90.76  ? 263 TYR C OH  1 
ATOM 7457  N N   . ILE C 1 270 ? 4.360   23.424  29.311  1.00 65.75  ? 264 ILE C N   1 
ATOM 7458  C CA  . ILE C 1 270 ? 5.140   22.505  28.500  1.00 65.70  ? 264 ILE C CA  1 
ATOM 7459  C C   . ILE C 1 270 ? 4.220   21.695  27.587  1.00 58.43  ? 264 ILE C C   1 
ATOM 7460  O O   . ILE C 1 270 ? 4.551   21.505  26.419  1.00 48.18  ? 264 ILE C O   1 
ATOM 7461  C CB  . ILE C 1 270 ? 6.006   21.627  29.427  1.00 70.76  ? 264 ILE C CB  1 
ATOM 7462  C CG1 . ILE C 1 270 ? 7.127   22.469  30.084  1.00 73.96  ? 264 ILE C CG1 1 
ATOM 7463  C CG2 . ILE C 1 270 ? 6.563   20.410  28.687  1.00 69.19  ? 264 ILE C CG2 1 
ATOM 7464  C CD1 . ILE C 1 270 ? 7.663   21.916  31.395  1.00 72.24  ? 264 ILE C CD1 1 
ATOM 7465  N N   . CYS C 1 271 ? 3.074   21.253  28.132  1.00 62.39  ? 265 CYS C N   1 
ATOM 7466  C CA  . CYS C 1 271 ? 2.073   20.472  27.413  1.00 69.79  ? 265 CYS C CA  1 
ATOM 7467  C C   . CYS C 1 271 ? 1.511   21.250  26.226  1.00 61.18  ? 265 CYS C C   1 
ATOM 7468  O O   . CYS C 1 271 ? 1.239   20.674  25.175  1.00 60.26  ? 265 CYS C O   1 
ATOM 7469  C CB  . CYS C 1 271 ? 0.908   20.064  28.314  1.00 77.15  ? 265 CYS C CB  1 
ATOM 7470  S SG  . CYS C 1 271 ? 1.372   18.893  29.619  1.00 96.43  ? 265 CYS C SG  1 
ATOM 7471  N N   . GLU C 1 272 ? 1.338   22.557  26.408  1.00 56.12  ? 266 GLU C N   1 
ATOM 7472  C CA  . GLU C 1 272 ? 0.837   23.410  25.348  1.00 61.69  ? 266 GLU C CA  1 
ATOM 7473  C C   . GLU C 1 272 ? 1.949   23.801  24.370  1.00 59.61  ? 266 GLU C C   1 
ATOM 7474  O O   . GLU C 1 272 ? 1.651   24.252  23.267  1.00 54.54  ? 266 GLU C O   1 
ATOM 7475  C CB  . GLU C 1 272 ? 0.176   24.624  25.992  1.00 71.88  ? 266 GLU C CB  1 
ATOM 7476  C CG  . GLU C 1 272 ? -1.067  24.263  26.800  1.00 79.97  ? 266 GLU C CG  1 
ATOM 7477  C CD  . GLU C 1 272 ? -1.601  25.376  27.686  1.00 88.75  ? 266 GLU C CD  1 
ATOM 7478  O OE1 . GLU C 1 272 ? -0.827  26.280  28.075  1.00 88.83  ? 266 GLU C OE1 1 
ATOM 7479  O OE2 . GLU C 1 272 ? -2.818  25.341  27.970  1.00 100.94 ? 266 GLU C OE2 1 
ATOM 7480  N N   . ASN C 1 273 ? 3.222   23.620  24.753  1.00 60.05  ? 267 ASN C N   1 
ATOM 7481  C CA  . ASN C 1 273 ? 4.333   24.037  23.912  1.00 63.55  ? 267 ASN C CA  1 
ATOM 7482  C C   . ASN C 1 273 ? 5.212   22.854  23.499  1.00 68.58  ? 267 ASN C C   1 
ATOM 7483  O O   . ASN C 1 273 ? 6.391   23.033  23.200  1.00 68.63  ? 267 ASN C O   1 
ATOM 7484  C CB  . ASN C 1 273 ? 5.150   25.124  24.597  1.00 63.43  ? 267 ASN C CB  1 
ATOM 7485  C CG  . ASN C 1 273 ? 4.388   26.423  24.691  1.00 63.85  ? 267 ASN C CG  1 
ATOM 7486  O OD1 . ASN C 1 273 ? 4.242   27.129  23.689  1.00 61.74  ? 267 ASN C OD1 1 
ATOM 7487  N ND2 . ASN C 1 273 ? 3.912   26.765  25.877  1.00 69.74  ? 267 ASN C ND2 1 
ATOM 7488  N N   . GLN C 1 274 ? 4.619   21.659  23.395  1.00 73.52  ? 268 GLN C N   1 
ATOM 7489  C CA  . GLN C 1 274 ? 5.372   20.450  23.095  1.00 74.54  ? 268 GLN C CA  1 
ATOM 7490  C C   . GLN C 1 274 ? 6.224   20.621  21.844  1.00 73.26  ? 268 GLN C C   1 
ATOM 7491  O O   . GLN C 1 274 ? 7.391   20.230  21.835  1.00 75.20  ? 268 GLN C O   1 
ATOM 7492  C CB  . GLN C 1 274 ? 4.456   19.272  22.790  1.00 74.67  ? 268 GLN C CB  1 
ATOM 7493  C CG  . GLN C 1 274 ? 3.649   18.798  23.987  1.00 80.34  ? 268 GLN C CG  1 
ATOM 7494  C CD  . GLN C 1 274 ? 2.587   17.800  23.594  1.00 81.65  ? 268 GLN C CD  1 
ATOM 7495  O OE1 . GLN C 1 274 ? 2.874   16.627  23.326  1.00 85.07  ? 268 GLN C OE1 1 
ATOM 7496  N NE2 . GLN C 1 274 ? 1.348   18.268  23.552  1.00 82.40  ? 268 GLN C NE2 1 
ATOM 7497  N N   . ASP C 1 275 ? 5.610   21.191  20.800  1.00 69.91  ? 269 ASP C N   1 
ATOM 7498  C CA  . ASP C 1 275 ? 6.169   21.171  19.461  1.00 66.79  ? 269 ASP C CA  1 
ATOM 7499  C C   . ASP C 1 275 ? 7.450   21.996  19.429  1.00 68.91  ? 269 ASP C C   1 
ATOM 7500  O O   . ASP C 1 275 ? 8.333   21.718  18.620  1.00 80.51  ? 269 ASP C O   1 
ATOM 7501  C CB  . ASP C 1 275 ? 5.148   21.628  18.431  1.00 74.01  ? 269 ASP C CB  1 
ATOM 7502  C CG  . ASP C 1 275 ? 3.893   20.771  18.282  1.00 78.38  ? 269 ASP C CG  1 
ATOM 7503  O OD1 . ASP C 1 275 ? 3.755   19.774  19.014  1.00 81.58  ? 269 ASP C OD1 1 
ATOM 7504  O OD2 . ASP C 1 275 ? 3.051   21.108  17.427  1.00 81.83  ? 269 ASP C OD2 1 
ATOM 7505  N N   . SER C 1 276 ? 7.572   22.978  20.333  1.00 66.75  ? 270 SER C N   1 
ATOM 7506  C CA  . SER C 1 276 ? 8.807   23.738  20.430  1.00 72.47  ? 270 SER C CA  1 
ATOM 7507  C C   . SER C 1 276 ? 9.826   23.108  21.385  1.00 71.04  ? 270 SER C C   1 
ATOM 7508  O O   . SER C 1 276 ? 10.901  23.679  21.574  1.00 73.41  ? 270 SER C O   1 
ATOM 7509  C CB  . SER C 1 276 ? 8.528   25.156  20.830  1.00 79.70  ? 270 SER C CB  1 
ATOM 7510  O OG  . SER C 1 276 ? 9.744   25.814  21.179  1.00 83.12  ? 270 SER C OG  1 
ATOM 7511  N N   . ILE C 1 277 ? 9.518   21.934  21.959  1.00 70.38  ? 271 ILE C N   1 
ATOM 7512  C CA  . ILE C 1 277 ? 10.250  21.431  23.115  1.00 67.36  ? 271 ILE C CA  1 
ATOM 7513  C C   . ILE C 1 277 ? 10.679  19.981  22.901  1.00 65.10  ? 271 ILE C C   1 
ATOM 7514  O O   . ILE C 1 277 ? 11.877  19.683  22.904  1.00 76.27  ? 271 ILE C O   1 
ATOM 7515  C CB  . ILE C 1 277 ? 9.421   21.590  24.402  1.00 65.52  ? 271 ILE C CB  1 
ATOM 7516  C CG1 . ILE C 1 277 ? 9.106   23.050  24.706  1.00 59.28  ? 271 ILE C CG1 1 
ATOM 7517  C CG2 . ILE C 1 277 ? 10.135  20.932  25.581  1.00 68.70  ? 271 ILE C CG2 1 
ATOM 7518  C CD1 . ILE C 1 277 ? 8.105   23.237  25.828  1.00 57.42  ? 271 ILE C CD1 1 
ATOM 7519  N N   . SER C 1 278 ? 9.715   19.066  22.758  1.00 58.78  ? 272 SER C N   1 
ATOM 7520  C CA  . SER C 1 278 ? 10.085  17.681  22.510  1.00 67.79  ? 272 SER C CA  1 
ATOM 7521  C C   . SER C 1 278 ? 8.961   16.903  21.824  1.00 66.89  ? 272 SER C C   1 
ATOM 7522  O O   . SER C 1 278 ? 7.778   17.162  22.051  1.00 67.06  ? 272 SER C O   1 
ATOM 7523  C CB  . SER C 1 278 ? 10.517  17.009  23.795  1.00 79.31  ? 272 SER C CB  1 
ATOM 7524  O OG  . SER C 1 278 ? 11.211  15.791  23.550  1.00 94.51  ? 272 SER C OG  1 
ATOM 7525  N N   . SER C 1 279 ? 9.364   15.923  21.000  1.00 65.32  ? 273 SER C N   1 
ATOM 7526  C CA  . SER C 1 279 ? 8.458   14.968  20.378  1.00 62.84  ? 273 SER C CA  1 
ATOM 7527  C C   . SER C 1 279 ? 8.144   13.801  21.310  1.00 59.65  ? 273 SER C C   1 
ATOM 7528  O O   . SER C 1 279 ? 7.481   12.869  20.889  1.00 59.69  ? 273 SER C O   1 
ATOM 7529  C CB  . SER C 1 279 ? 9.055   14.423  19.133  1.00 63.37  ? 273 SER C CB  1 
ATOM 7530  O OG  . SER C 1 279 ? 10.191  13.644  19.482  1.00 67.81  ? 273 SER C OG  1 
ATOM 7531  N N   . LYS C 1 280 ? 8.616   13.852  22.560  1.00 61.90  ? 274 LYS C N   1 
ATOM 7532  C CA  . LYS C 1 280 ? 8.468   12.753  23.498  1.00 63.74  ? 274 LYS C CA  1 
ATOM 7533  C C   . LYS C 1 280 ? 7.301   12.989  24.459  1.00 67.62  ? 274 LYS C C   1 
ATOM 7534  O O   . LYS C 1 280 ? 6.922   12.098  25.223  1.00 66.37  ? 274 LYS C O   1 
ATOM 7535  C CB  . LYS C 1 280 ? 9.794   12.617  24.253  1.00 64.97  ? 274 LYS C CB  1 
ATOM 7536  C CG  . LYS C 1 280 ? 11.019  12.434  23.370  1.00 65.68  ? 274 LYS C CG  1 
ATOM 7537  C CD  . LYS C 1 280 ? 10.886  11.242  22.430  1.00 70.01  ? 274 LYS C CD  1 
ATOM 7538  C CE  . LYS C 1 280 ? 12.107  10.935  21.616  1.00 73.60  ? 274 LYS C CE  1 
ATOM 7539  N NZ  . LYS C 1 280 ? 11.896  9.813   20.694  1.00 72.39  ? 274 LYS C NZ  1 
ATOM 7540  N N   . LEU C 1 281 ? 6.697   14.177  24.401  1.00 66.44  ? 275 LEU C N   1 
ATOM 7541  C CA  . LEU C 1 281 ? 5.807   14.595  25.467  1.00 70.34  ? 275 LEU C CA  1 
ATOM 7542  C C   . LEU C 1 281 ? 4.345   14.262  25.176  1.00 75.58  ? 275 LEU C C   1 
ATOM 7543  O O   . LEU C 1 281 ? 3.493   14.565  26.007  1.00 80.63  ? 275 LEU C O   1 
ATOM 7544  C CB  . LEU C 1 281 ? 6.014   16.091  25.661  1.00 74.98  ? 275 LEU C CB  1 
ATOM 7545  C CG  . LEU C 1 281 ? 7.320   16.490  26.349  1.00 76.21  ? 275 LEU C CG  1 
ATOM 7546  C CD1 . LEU C 1 281 ? 7.716   17.898  25.951  1.00 78.57  ? 275 LEU C CD1 1 
ATOM 7547  C CD2 . LEU C 1 281 ? 7.147   16.378  27.852  1.00 74.42  ? 275 LEU C CD2 1 
ATOM 7548  N N   . LYS C 1 282 ? 4.038   13.640  24.030  1.00 82.06  ? 276 LYS C N   1 
ATOM 7549  C CA  . LYS C 1 282 ? 2.644   13.427  23.662  1.00 86.57  ? 276 LYS C CA  1 
ATOM 7550  C C   . LYS C 1 282 ? 1.997   12.451  24.637  1.00 79.73  ? 276 LYS C C   1 
ATOM 7551  O O   . LYS C 1 282 ? 0.946   12.741  25.200  1.00 74.91  ? 276 LYS C O   1 
ATOM 7552  C CB  . LYS C 1 282 ? 2.458   12.898  22.235  1.00 95.92  ? 276 LYS C CB  1 
ATOM 7553  C CG  . LYS C 1 282 ? 1.009   12.960  21.748  1.00 100.75 ? 276 LYS C CG  1 
ATOM 7554  C CD  . LYS C 1 282 ? 0.775   12.361  20.369  1.00 109.59 ? 276 LYS C CD  1 
ATOM 7555  C CE  . LYS C 1 282 ? 1.001   10.876  20.351  1.00 119.61 ? 276 LYS C CE  1 
ATOM 7556  N NZ  . LYS C 1 282 ? 0.732   10.278  19.041  1.00 123.79 ? 276 LYS C NZ  1 
ATOM 7557  N N   . GLU C 1 283 ? 2.649   11.296  24.808  1.00 88.33  ? 277 GLU C N   1 
ATOM 7558  C CA  . GLU C 1 283 ? 2.184   10.232  25.691  1.00 92.21  ? 277 GLU C CA  1 
ATOM 7559  C C   . GLU C 1 283 ? 1.978   10.775  27.108  1.00 81.88  ? 277 GLU C C   1 
ATOM 7560  O O   . GLU C 1 283 ? 0.973   10.467  27.737  1.00 81.48  ? 277 GLU C O   1 
ATOM 7561  C CB  . GLU C 1 283 ? 3.090   8.993   25.592  1.00 96.73  ? 277 GLU C CB  1 
ATOM 7562  C CG  . GLU C 1 283 ? 4.594   9.273   25.510  1.00 105.92 ? 277 GLU C CG  1 
ATOM 7563  C CD  . GLU C 1 283 ? 5.488   8.095   25.123  1.00 106.41 ? 277 GLU C CD  1 
ATOM 7564  O OE1 . GLU C 1 283 ? 5.370   7.031   25.768  1.00 115.37 ? 277 GLU C OE1 1 
ATOM 7565  O OE2 . GLU C 1 283 ? 6.326   8.233   24.200  1.00 91.54  ? 277 GLU C OE2 1 
ATOM 7566  N N   . CYS C 1 284 ? 2.909   11.612  27.585  1.00 75.25  ? 278 CYS C N   1 
ATOM 7567  C CA  . CYS C 1 284 ? 2.870   12.137  28.943  1.00 67.64  ? 278 CYS C CA  1 
ATOM 7568  C C   . CYS C 1 284 ? 1.703   13.103  29.121  1.00 61.13  ? 278 CYS C C   1 
ATOM 7569  O O   . CYS C 1 284 ? 0.959   12.998  30.089  1.00 63.97  ? 278 CYS C O   1 
ATOM 7570  C CB  . CYS C 1 284 ? 4.132   12.919  29.304  1.00 69.63  ? 278 CYS C CB  1 
ATOM 7571  S SG  . CYS C 1 284 ? 5.681   11.994  29.127  1.00 64.84  ? 278 CYS C SG  1 
ATOM 7572  N N   . CYS C 1 285 ? 1.567   14.050  28.185  1.00 58.49  ? 279 CYS C N   1 
ATOM 7573  C CA  . CYS C 1 285 ? 0.754   15.240  28.390  1.00 58.18  ? 279 CYS C CA  1 
ATOM 7574  C C   . CYS C 1 285 ? -0.720  14.940  28.125  1.00 61.22  ? 279 CYS C C   1 
ATOM 7575  O O   . CYS C 1 285 ? -1.534  15.850  28.012  1.00 55.78  ? 279 CYS C O   1 
ATOM 7576  C CB  . CYS C 1 285 ? 1.291   16.403  27.559  1.00 57.08  ? 279 CYS C CB  1 
ATOM 7577  S SG  . CYS C 1 285 ? 2.811   17.135  28.236  1.00 60.44  ? 279 CYS C SG  1 
ATOM 7578  N N   . GLU C 1 286 ? -1.048  13.652  28.001  1.00 72.36  ? 280 GLU C N   1 
ATOM 7579  C CA  . GLU C 1 286 ? -2.428  13.208  27.984  1.00 74.97  ? 280 GLU C CA  1 
ATOM 7580  C C   . GLU C 1 286 ? -2.824  12.739  29.378  1.00 73.22  ? 280 GLU C C   1 
ATOM 7581  O O   . GLU C 1 286 ? -4.008  12.684  29.687  1.00 72.67  ? 280 GLU C O   1 
ATOM 7582  C CB  . GLU C 1 286 ? -2.579  12.119  26.927  1.00 78.37  ? 280 GLU C CB  1 
ATOM 7583  C CG  . GLU C 1 286 ? -2.405  12.684  25.522  1.00 87.82  ? 280 GLU C CG  1 
ATOM 7584  C CD  . GLU C 1 286 ? -2.369  11.659  24.408  1.00 99.02  ? 280 GLU C CD  1 
ATOM 7585  O OE1 . GLU C 1 286 ? -2.531  10.450  24.694  1.00 102.44 ? 280 GLU C OE1 1 
ATOM 7586  O OE2 . GLU C 1 286 ? -2.176  12.090  23.247  1.00 102.76 ? 280 GLU C OE2 1 
ATOM 7587  N N   . LYS C 1 287 ? -1.828  12.453  30.225  1.00 77.54  ? 281 LYS C N   1 
ATOM 7588  C CA  . LYS C 1 287 ? -2.062  11.803  31.506  1.00 79.58  ? 281 LYS C CA  1 
ATOM 7589  C C   . LYS C 1 287 ? -2.693  12.801  32.479  1.00 79.91  ? 281 LYS C C   1 
ATOM 7590  O O   . LYS C 1 287 ? -2.668  14.009  32.250  1.00 85.62  ? 281 LYS C O   1 
ATOM 7591  C CB  . LYS C 1 287 ? -0.762  11.125  31.977  1.00 80.80  ? 281 LYS C CB  1 
ATOM 7592  C CG  . LYS C 1 287 ? -0.244  10.114  30.959  1.00 80.74  ? 281 LYS C CG  1 
ATOM 7593  C CD  . LYS C 1 287 ? 0.672   8.989   31.418  1.00 80.06  ? 281 LYS C CD  1 
ATOM 7594  C CE  . LYS C 1 287 ? 0.752   7.983   30.298  1.00 80.45  ? 281 LYS C CE  1 
ATOM 7595  N NZ  . LYS C 1 287 ? 1.613   6.839   30.594  1.00 83.17  ? 281 LYS C NZ  1 
ATOM 7596  N N   . PRO C 1 288 ? -3.306  12.327  33.590  1.00 84.70  ? 282 PRO C N   1 
ATOM 7597  C CA  . PRO C 1 288 ? -3.889  13.220  34.597  1.00 78.75  ? 282 PRO C CA  1 
ATOM 7598  C C   . PRO C 1 288 ? -2.860  14.203  35.147  1.00 73.78  ? 282 PRO C C   1 
ATOM 7599  O O   . PRO C 1 288 ? -1.665  13.995  34.979  1.00 71.56  ? 282 PRO C O   1 
ATOM 7600  C CB  . PRO C 1 288 ? -4.411  12.269  35.702  1.00 79.51  ? 282 PRO C CB  1 
ATOM 7601  C CG  . PRO C 1 288 ? -4.471  10.894  35.060  1.00 80.21  ? 282 PRO C CG  1 
ATOM 7602  C CD  . PRO C 1 288 ? -3.447  10.901  33.943  1.00 84.72  ? 282 PRO C CD  1 
ATOM 7603  N N   . LEU C 1 289 ? -3.331  15.228  35.865  1.00 82.65  ? 283 LEU C N   1 
ATOM 7604  C CA  . LEU C 1 289 ? -2.493  16.356  36.254  1.00 90.11  ? 283 LEU C CA  1 
ATOM 7605  C C   . LEU C 1 289 ? -1.343  15.903  37.160  1.00 82.18  ? 283 LEU C C   1 
ATOM 7606  O O   . LEU C 1 289 ? -0.210  16.345  36.992  1.00 81.78  ? 283 LEU C O   1 
ATOM 7607  C CB  . LEU C 1 289 ? -3.329  17.456  36.914  1.00 97.15  ? 283 LEU C CB  1 
ATOM 7608  C CG  . LEU C 1 289 ? -2.927  18.910  36.608  1.00 111.06 ? 283 LEU C CG  1 
ATOM 7609  C CD1 . LEU C 1 289 ? -1.413  19.159  36.590  1.00 109.77 ? 283 LEU C CD1 1 
ATOM 7610  C CD2 . LEU C 1 289 ? -3.555  19.411  35.301  1.00 112.74 ? 283 LEU C CD2 1 
ATOM 7611  N N   . LEU C 1 290 ? -1.613  15.020  38.123  1.00 78.90  ? 284 LEU C N   1 
ATOM 7612  C CA  . LEU C 1 290 ? -0.566  14.569  39.029  1.00 78.08  ? 284 LEU C CA  1 
ATOM 7613  C C   . LEU C 1 290 ? 0.491   13.766  38.273  1.00 72.12  ? 284 LEU C C   1 
ATOM 7614  O O   . LEU C 1 290 ? 1.677   14.034  38.429  1.00 59.12  ? 284 LEU C O   1 
ATOM 7615  C CB  . LEU C 1 290 ? -1.133  13.755  40.194  1.00 86.47  ? 284 LEU C CB  1 
ATOM 7616  C CG  . LEU C 1 290 ? -1.407  14.503  41.508  1.00 80.02  ? 284 LEU C CG  1 
ATOM 7617  C CD1 . LEU C 1 290 ? -0.133  15.112  42.073  1.00 73.55  ? 284 LEU C CD1 1 
ATOM 7618  C CD2 . LEU C 1 290 ? -2.502  15.561  41.352  1.00 80.16  ? 284 LEU C CD2 1 
ATOM 7619  N N   . GLU C 1 291 ? 0.047   12.754  37.509  1.00 75.84  ? 285 GLU C N   1 
ATOM 7620  C CA  . GLU C 1 291 ? 0.937   11.892  36.741  1.00 80.73  ? 285 GLU C CA  1 
ATOM 7621  C C   . GLU C 1 291 ? 1.773   12.719  35.769  1.00 78.43  ? 285 GLU C C   1 
ATOM 7622  O O   . GLU C 1 291 ? 2.993   12.597  35.752  1.00 82.51  ? 285 GLU C O   1 
ATOM 7623  C CB  . GLU C 1 291 ? 0.198   10.874  35.867  1.00 88.49  ? 285 GLU C CB  1 
ATOM 7624  C CG  . GLU C 1 291 ? -0.225  9.590   36.575  1.00 89.70  ? 285 GLU C CG  1 
ATOM 7625  C CD  . GLU C 1 291 ? -0.844  8.581   35.625  1.00 84.36  ? 285 GLU C CD  1 
ATOM 7626  O OE1 . GLU C 1 291 ? -0.125  8.105   34.725  1.00 72.41  ? 285 GLU C OE1 1 
ATOM 7627  O OE2 . GLU C 1 291 ? -2.050  8.292   35.767  1.00 90.46  ? 285 GLU C OE2 1 
ATOM 7628  N N   . LYS C 1 292 ? 1.074   13.512  34.945  1.00 75.27  ? 286 LYS C N   1 
ATOM 7629  C CA  . LYS C 1 292 ? 1.647   14.358  33.907  1.00 74.28  ? 286 LYS C CA  1 
ATOM 7630  C C   . LYS C 1 292 ? 2.977   14.981  34.323  1.00 66.10  ? 286 LYS C C   1 
ATOM 7631  O O   . LYS C 1 292 ? 3.964   14.843  33.604  1.00 57.70  ? 286 LYS C O   1 
ATOM 7632  C CB  . LYS C 1 292 ? 0.620   15.455  33.602  1.00 79.69  ? 286 LYS C CB  1 
ATOM 7633  C CG  . LYS C 1 292 ? 1.059   16.604  32.703  1.00 81.11  ? 286 LYS C CG  1 
ATOM 7634  C CD  . LYS C 1 292 ? -0.012  17.679  32.573  1.00 83.35  ? 286 LYS C CD  1 
ATOM 7635  C CE  . LYS C 1 292 ? -1.238  17.191  31.880  1.00 91.26  ? 286 LYS C CE  1 
ATOM 7636  N NZ  . LYS C 1 292 ? -2.144  18.309  31.604  1.00 103.06 ? 286 LYS C NZ  1 
ATOM 7637  N N   . SER C 1 293 ? 2.984   15.670  35.475  1.00 65.44  ? 287 SER C N   1 
ATOM 7638  C CA  . SER C 1 293 ? 4.129   16.463  35.912  1.00 72.81  ? 287 SER C CA  1 
ATOM 7639  C C   . SER C 1 293 ? 5.306   15.598  36.398  1.00 70.74  ? 287 SER C C   1 
ATOM 7640  O O   . SER C 1 293 ? 6.476   15.968  36.244  1.00 69.63  ? 287 SER C O   1 
ATOM 7641  C CB  . SER C 1 293 ? 3.711   17.510  36.933  1.00 72.66  ? 287 SER C CB  1 
ATOM 7642  O OG  . SER C 1 293 ? 2.594   17.084  37.697  1.00 85.90  ? 287 SER C OG  1 
ATOM 7643  N N   . HIS C 1 294 ? 5.023   14.430  36.974  1.00 68.76  ? 288 HIS C N   1 
ATOM 7644  C CA  . HIS C 1 294 ? 6.087   13.492  37.288  1.00 66.94  ? 288 HIS C CA  1 
ATOM 7645  C C   . HIS C 1 294 ? 6.663   12.928  35.996  1.00 65.06  ? 288 HIS C C   1 
ATOM 7646  O O   . HIS C 1 294 ? 7.861   12.699  35.894  1.00 71.41  ? 288 HIS C O   1 
ATOM 7647  C CB  . HIS C 1 294 ? 5.579   12.359  38.183  1.00 71.99  ? 288 HIS C CB  1 
ATOM 7648  C CG  . HIS C 1 294 ? 6.541   11.220  38.290  1.00 73.02  ? 288 HIS C CG  1 
ATOM 7649  N ND1 . HIS C 1 294 ? 7.745   11.324  38.952  1.00 75.74  ? 288 HIS C ND1 1 
ATOM 7650  C CD2 . HIS C 1 294 ? 6.500   9.984   37.784  1.00 67.56  ? 288 HIS C CD2 1 
ATOM 7651  C CE1 . HIS C 1 294 ? 8.389   10.173  38.870  1.00 74.85  ? 288 HIS C CE1 1 
ATOM 7652  N NE2 . HIS C 1 294 ? 7.644   9.344   38.171  1.00 70.16  ? 288 HIS C NE2 1 
ATOM 7653  N N   . CYS C 1 295 ? 5.782   12.713  35.019  1.00 66.82  ? 289 CYS C N   1 
ATOM 7654  C CA  . CYS C 1 295 ? 6.113   12.019  33.788  1.00 68.23  ? 289 CYS C CA  1 
ATOM 7655  C C   . CYS C 1 295 ? 7.091   12.861  32.973  1.00 59.44  ? 289 CYS C C   1 
ATOM 7656  O O   . CYS C 1 295 ? 8.141   12.344  32.583  1.00 45.96  ? 289 CYS C O   1 
ATOM 7657  C CB  . CYS C 1 295 ? 4.827   11.693  33.035  1.00 78.67  ? 289 CYS C CB  1 
ATOM 7658  S SG  . CYS C 1 295 ? 4.972   10.303  31.886  1.00 97.92  ? 289 CYS C SG  1 
ATOM 7659  N N   . ILE C 1 296 ? 6.748   14.157  32.782  1.00 57.18  ? 290 ILE C N   1 
ATOM 7660  C CA  . ILE C 1 296 ? 7.505   15.059  31.921  1.00 56.35  ? 290 ILE C CA  1 
ATOM 7661  C C   . ILE C 1 296 ? 8.924   15.175  32.465  1.00 59.21  ? 290 ILE C C   1 
ATOM 7662  O O   . ILE C 1 296 ? 9.843   15.520  31.727  1.00 57.14  ? 290 ILE C O   1 
ATOM 7663  C CB  . ILE C 1 296 ? 6.865   16.457  31.736  1.00 57.77  ? 290 ILE C CB  1 
ATOM 7664  C CG1 . ILE C 1 296 ? 6.891   17.313  33.002  1.00 61.76  ? 290 ILE C CG1 1 
ATOM 7665  C CG2 . ILE C 1 296 ? 5.455   16.382  31.148  1.00 63.52  ? 290 ILE C CG2 1 
ATOM 7666  C CD1 . ILE C 1 296 ? 8.071   18.273  33.096  1.00 65.51  ? 290 ILE C CD1 1 
ATOM 7667  N N   . ALA C 1 297 ? 9.094   14.925  33.767  1.00 61.55  ? 291 ALA C N   1 
ATOM 7668  C CA  . ALA C 1 297 ? 10.406  15.062  34.372  1.00 63.50  ? 291 ALA C CA  1 
ATOM 7669  C C   . ALA C 1 297 ? 11.237  13.831  34.027  1.00 59.88  ? 291 ALA C C   1 
ATOM 7670  O O   . ALA C 1 297 ? 12.464  13.885  34.055  1.00 61.80  ? 291 ALA C O   1 
ATOM 7671  C CB  . ALA C 1 297 ? 10.276  15.293  35.866  1.00 60.95  ? 291 ALA C CB  1 
ATOM 7672  N N   . GLU C 1 298 ? 10.573  12.735  33.673  1.00 56.91  ? 292 GLU C N   1 
ATOM 7673  C CA  . GLU C 1 298 ? 11.292  11.462  33.431  1.00 61.14  ? 292 GLU C CA  1 
ATOM 7674  C C   . GLU C 1 298 ? 11.256  11.110  31.951  1.00 60.69  ? 292 GLU C C   1 
ATOM 7675  O O   . GLU C 1 298 ? 11.705  10.016  31.594  1.00 60.16  ? 292 GLU C O   1 
ATOM 7676  C CB  . GLU C 1 298 ? 10.595  10.331  34.176  1.00 67.19  ? 292 GLU C CB  1 
ATOM 7677  C CG  . GLU C 1 298 ? 10.774  10.382  35.688  1.00 74.72  ? 292 GLU C CG  1 
ATOM 7678  C CD  . GLU C 1 298 ? 10.779  8.987   36.278  1.00 85.68  ? 292 GLU C CD  1 
ATOM 7679  O OE1 . GLU C 1 298 ? 10.405  8.053   35.544  1.00 101.46 ? 292 GLU C OE1 1 
ATOM 7680  O OE2 . GLU C 1 298 ? 11.159  8.831   37.456  1.00 95.46  ? 292 GLU C OE2 1 
ATOM 7681  N N   . VAL C 1 299 ? 10.779  12.029  31.125  1.00 63.07  ? 293 VAL C N   1 
ATOM 7682  C CA  . VAL C 1 299 ? 10.634  11.766  29.666  1.00 57.07  ? 293 VAL C CA  1 
ATOM 7683  C C   . VAL C 1 299 ? 12.028  11.564  29.069  1.00 60.76  ? 293 VAL C C   1 
ATOM 7684  O O   . VAL C 1 299 ? 12.988  12.172  29.572  1.00 54.06  ? 293 VAL C O   1 
ATOM 7685  C CB  . VAL C 1 299 ? 9.830   12.817  28.880  1.00 54.04  ? 293 VAL C CB  1 
ATOM 7686  C CG1 . VAL C 1 299 ? 10.691  13.986  28.426  1.00 55.23  ? 293 VAL C CG1 1 
ATOM 7687  C CG2 . VAL C 1 299 ? 9.107   12.193  27.698  1.00 57.35  ? 293 VAL C CG2 1 
ATOM 7688  N N   . GLU C 1 300 ? 12.121  10.672  28.095  1.00 69.13  ? 294 GLU C N   1 
ATOM 7689  C CA  . GLU C 1 300 ? 13.394  10.332  27.423  1.00 71.20  ? 294 GLU C CA  1 
ATOM 7690  C C   . GLU C 1 300 ? 13.911  11.497  26.574  1.00 63.26  ? 294 GLU C C   1 
ATOM 7691  O O   . GLU C 1 300 ? 13.103  12.284  26.076  1.00 60.48  ? 294 GLU C O   1 
ATOM 7692  C CB  . GLU C 1 300 ? 13.122  9.072   26.602  1.00 78.33  ? 294 GLU C CB  1 
ATOM 7693  C CG  . GLU C 1 300 ? 11.762  9.067   25.913  1.00 81.04  ? 294 GLU C CG  1 
ATOM 7694  C CD  . GLU C 1 300 ? 11.737  8.203   24.667  1.00 86.09  ? 294 GLU C CD  1 
ATOM 7695  O OE1 . GLU C 1 300 ? 12.822  7.943   24.110  1.00 88.59  ? 294 GLU C OE1 1 
ATOM 7696  O OE2 . GLU C 1 300 ? 10.637  7.789   24.252  1.00 89.46  ? 294 GLU C OE2 1 
ATOM 7697  N N   . ASN C 1 301 ? 15.225  11.563  26.411  1.00 55.76  ? 295 ASN C N   1 
ATOM 7698  C CA  . ASN C 1 301 ? 15.870  12.635  25.626  1.00 52.29  ? 295 ASN C CA  1 
ATOM 7699  C C   . ASN C 1 301 ? 15.358  12.612  24.187  1.00 58.31  ? 295 ASN C C   1 
ATOM 7700  O O   . ASN C 1 301 ? 15.166  11.513  23.664  1.00 64.61  ? 295 ASN C O   1 
ATOM 7701  C CB  . ASN C 1 301 ? 17.384  12.478  25.692  1.00 49.38  ? 295 ASN C CB  1 
ATOM 7702  C CG  . ASN C 1 301 ? 17.956  12.740  27.060  1.00 48.93  ? 295 ASN C CG  1 
ATOM 7703  O OD1 . ASN C 1 301 ? 17.212  13.005  28.007  1.00 54.21  ? 295 ASN C OD1 1 
ATOM 7704  N ND2 . ASN C 1 301 ? 19.272  12.665  27.180  1.00 47.40  ? 295 ASN C ND2 1 
ATOM 7705  N N   . ASP C 1 302 ? 15.086  13.776  23.602  1.00 61.98  ? 296 ASP C N   1 
ATOM 7706  C CA  . ASP C 1 302 ? 14.687  13.915  22.172  1.00 61.17  ? 296 ASP C CA  1 
ATOM 7707  C C   . ASP C 1 302 ? 15.898  13.669  21.281  1.00 62.94  ? 296 ASP C C   1 
ATOM 7708  O O   . ASP C 1 302 ? 17.029  13.787  21.764  1.00 61.70  ? 296 ASP C O   1 
ATOM 7709  C CB  . ASP C 1 302 ? 13.999  15.233  21.852  1.00 64.93  ? 296 ASP C CB  1 
ATOM 7710  C CG  . ASP C 1 302 ? 13.043  15.215  20.673  1.00 62.36  ? 296 ASP C CG  1 
ATOM 7711  O OD1 . ASP C 1 302 ? 12.910  14.153  20.038  1.00 51.00  ? 296 ASP C OD1 1 
ATOM 7712  O OD2 . ASP C 1 302 ? 12.446  16.270  20.404  1.00 58.90  ? 296 ASP C OD2 1 
ATOM 7713  N N   . GLU C 1 303 ? 15.650  13.281  20.041  1.00 69.43  ? 297 GLU C N   1 
ATOM 7714  C CA  . GLU C 1 303 ? 16.747  12.973  19.101  1.00 70.93  ? 297 GLU C CA  1 
ATOM 7715  C C   . GLU C 1 303 ? 17.552  14.244  18.845  1.00 65.73  ? 297 GLU C C   1 
ATOM 7716  O O   . GLU C 1 303 ? 16.959  15.323  18.783  1.00 62.66  ? 297 GLU C O   1 
ATOM 7717  C CB  . GLU C 1 303 ? 16.128  12.412  17.824  1.00 78.86  ? 297 GLU C CB  1 
ATOM 7718  C CG  . GLU C 1 303 ? 16.311  10.906  17.677  1.00 81.37  ? 297 GLU C CG  1 
ATOM 7719  C CD  . GLU C 1 303 ? 15.169  10.118  18.285  1.00 85.32  ? 297 GLU C CD  1 
ATOM 7720  O OE1 . GLU C 1 303 ? 14.058  10.676  18.366  1.00 97.55  ? 297 GLU C OE1 1 
ATOM 7721  O OE2 . GLU C 1 303 ? 15.387  8.955   18.676  1.00 80.32  ? 297 GLU C OE2 1 
ATOM 7722  N N   . MET C 1 304 ? 18.863  14.097  18.715  1.00 63.66  ? 298 MET C N   1 
ATOM 7723  C CA  . MET C 1 304 ? 19.741  15.277  18.576  1.00 70.59  ? 298 MET C CA  1 
ATOM 7724  C C   . MET C 1 304 ? 19.408  15.991  17.280  1.00 78.66  ? 298 MET C C   1 
ATOM 7725  O O   . MET C 1 304 ? 19.116  15.323  16.276  1.00 83.77  ? 298 MET C O   1 
ATOM 7726  C CB  . MET C 1 304 ? 21.216  14.884  18.523  1.00 69.91  ? 298 MET C CB  1 
ATOM 7727  C CG  . MET C 1 304 ? 21.939  15.020  19.836  1.00 75.23  ? 298 MET C CG  1 
ATOM 7728  S SD  . MET C 1 304 ? 23.703  15.055  19.479  1.00 81.31  ? 298 MET C SD  1 
ATOM 7729  C CE  . MET C 1 304 ? 23.691  16.301  18.184  1.00 80.16  ? 298 MET C CE  1 
ATOM 7730  N N   . PRO C 1 305 ? 19.460  17.330  17.278  1.00 84.57  ? 299 PRO C N   1 
ATOM 7731  C CA  . PRO C 1 305 ? 19.082  18.095  16.107  1.00 86.35  ? 299 PRO C CA  1 
ATOM 7732  C C   . PRO C 1 305 ? 19.927  17.938  14.858  1.00 77.34  ? 299 PRO C C   1 
ATOM 7733  O O   . PRO C 1 305 ? 21.144  17.703  14.940  1.00 68.96  ? 299 PRO C O   1 
ATOM 7734  C CB  . PRO C 1 305 ? 19.212  19.510  16.676  1.00 89.14  ? 299 PRO C CB  1 
ATOM 7735  C CG  . PRO C 1 305 ? 19.055  19.338  18.151  1.00 85.66  ? 299 PRO C CG  1 
ATOM 7736  C CD  . PRO C 1 305 ? 19.911  18.129  18.388  1.00 82.86  ? 299 PRO C CD  1 
ATOM 7737  N N   . ALA C 1 306 ? 19.307  18.132  13.708  1.00 69.67  ? 300 ALA C N   1 
ATOM 7738  C CA  . ALA C 1 306 ? 20.052  18.036  12.444  1.00 74.88  ? 300 ALA C CA  1 
ATOM 7739  C C   . ALA C 1 306 ? 20.792  19.328  12.122  1.00 78.62  ? 300 ALA C C   1 
ATOM 7740  O O   . ALA C 1 306 ? 20.326  20.409  12.508  1.00 84.78  ? 300 ALA C O   1 
ATOM 7741  C CB  . ALA C 1 306 ? 19.063  17.751  11.364  1.00 82.06  ? 300 ALA C CB  1 
ATOM 7742  N N   . ASP C 1 307 ? 21.897  19.221  11.398  1.00 77.73  ? 301 ASP C N   1 
ATOM 7743  C CA  . ASP C 1 307 ? 22.636  20.415  10.907  1.00 82.43  ? 301 ASP C CA  1 
ATOM 7744  C C   . ASP C 1 307 ? 23.117  21.335  12.023  1.00 66.36  ? 301 ASP C C   1 
ATOM 7745  O O   . ASP C 1 307 ? 23.036  22.552  11.850  1.00 62.88  ? 301 ASP C O   1 
ATOM 7746  C CB  . ASP C 1 307 ? 21.824  21.121  9.839   1.00 90.94  ? 301 ASP C CB  1 
ATOM 7747  C CG  . ASP C 1 307 ? 22.172  20.722  8.412   1.00 108.48 ? 301 ASP C CG  1 
ATOM 7748  O OD1 . ASP C 1 307 ? 22.850  19.689  8.245   1.00 110.37 ? 301 ASP C OD1 1 
ATOM 7749  O OD2 . ASP C 1 307 ? 21.771  21.448  7.479   1.00 122.60 ? 301 ASP C OD2 1 
ATOM 7750  N N   . LEU C 1 308 ? 23.529  20.770  13.147  1.00 59.47  ? 302 LEU C N   1 
ATOM 7751  C CA  . LEU C 1 308 ? 24.175  21.609  14.180  1.00 53.30  ? 302 LEU C CA  1 
ATOM 7752  C C   . LEU C 1 308 ? 25.548  22.037  13.674  1.00 51.75  ? 302 LEU C C   1 
ATOM 7753  O O   . LEU C 1 308 ? 26.236  21.216  13.066  1.00 55.13  ? 302 LEU C O   1 
ATOM 7754  C CB  . LEU C 1 308 ? 24.265  20.888  15.522  1.00 49.48  ? 302 LEU C CB  1 
ATOM 7755  C CG  . LEU C 1 308 ? 23.327  21.393  16.619  1.00 53.06  ? 302 LEU C CG  1 
ATOM 7756  C CD1 . LEU C 1 308 ? 22.041  21.893  16.003  1.00 58.69  ? 302 LEU C CD1 1 
ATOM 7757  C CD2 . LEU C 1 308 ? 23.045  20.282  17.606  1.00 53.82  ? 302 LEU C CD2 1 
ATOM 7758  N N   . PRO C 1 309 ? 25.970  23.283  13.909  1.00 56.55  ? 303 PRO C N   1 
ATOM 7759  C CA  . PRO C 1 309 ? 27.311  23.747  13.611  1.00 55.79  ? 303 PRO C CA  1 
ATOM 7760  C C   . PRO C 1 309 ? 28.306  23.186  14.610  1.00 47.54  ? 303 PRO C C   1 
ATOM 7761  O O   . PRO C 1 309 ? 27.917  22.708  15.669  1.00 41.98  ? 303 PRO C O   1 
ATOM 7762  C CB  . PRO C 1 309 ? 27.155  25.245  13.688  1.00 60.81  ? 303 PRO C CB  1 
ATOM 7763  C CG  . PRO C 1 309 ? 26.140  25.424  14.766  1.00 67.29  ? 303 PRO C CG  1 
ATOM 7764  C CD  . PRO C 1 309 ? 25.139  24.334  14.450  1.00 64.97  ? 303 PRO C CD  1 
ATOM 7765  N N   . SER C 1 310 ? 29.571  23.162  14.244  1.00 46.39  ? 304 SER C N   1 
ATOM 7766  C CA  . SER C 1 310 ? 30.608  22.693  15.183  1.00 50.36  ? 304 SER C CA  1 
ATOM 7767  C C   . SER C 1 310 ? 30.643  23.637  16.375  1.00 56.65  ? 304 SER C C   1 
ATOM 7768  O O   . SER C 1 310 ? 30.444  24.839  16.184  1.00 73.62  ? 304 SER C O   1 
ATOM 7769  C CB  . SER C 1 310 ? 31.953  22.679  14.545  1.00 50.35  ? 304 SER C CB  1 
ATOM 7770  O OG  . SER C 1 310 ? 32.933  23.201  15.429  1.00 57.75  ? 304 SER C OG  1 
ATOM 7771  N N   . LEU C 1 311 ? 30.890  23.109  17.560  1.00 64.75  ? 305 LEU C N   1 
ATOM 7772  C CA  . LEU C 1 311 ? 30.890  23.902  18.814  1.00 75.07  ? 305 LEU C CA  1 
ATOM 7773  C C   . LEU C 1 311 ? 31.984  24.956  18.722  1.00 77.33  ? 305 LEU C C   1 
ATOM 7774  O O   . LEU C 1 311 ? 31.721  26.089  19.146  1.00 80.81  ? 305 LEU C O   1 
ATOM 7775  C CB  . LEU C 1 311 ? 31.117  22.980  20.005  1.00 81.06  ? 305 LEU C CB  1 
ATOM 7776  C CG  . LEU C 1 311 ? 30.881  23.591  21.388  1.00 86.29  ? 305 LEU C CG  1 
ATOM 7777  C CD1 . LEU C 1 311 ? 29.397  23.667  21.668  1.00 90.03  ? 305 LEU C CD1 1 
ATOM 7778  C CD2 . LEU C 1 311 ? 31.574  22.758  22.443  1.00 86.73  ? 305 LEU C CD2 1 
ATOM 7779  N N   . ALA C 1 312 ? 33.125  24.628  18.137  1.00 66.07  ? 306 ALA C N   1 
ATOM 7780  C CA  . ALA C 1 312 ? 34.324  25.489  18.118  1.00 61.54  ? 306 ALA C CA  1 
ATOM 7781  C C   . ALA C 1 312 ? 34.028  26.800  17.412  1.00 61.04  ? 306 ALA C C   1 
ATOM 7782  O O   . ALA C 1 312 ? 34.622  27.816  17.789  1.00 56.23  ? 306 ALA C O   1 
ATOM 7783  C CB  . ALA C 1 312 ? 35.440  24.757  17.449  1.00 61.02  ? 306 ALA C CB  1 
ATOM 7784  N N   . ALA C 1 313 ? 33.224  26.788  16.369  1.00 58.54  ? 307 ALA C N   1 
ATOM 7785  C CA  . ALA C 1 313 ? 33.081  28.009  15.559  1.00 65.59  ? 307 ALA C CA  1 
ATOM 7786  C C   . ALA C 1 313 ? 32.532  29.223  16.309  1.00 70.10  ? 307 ALA C C   1 
ATOM 7787  O O   . ALA C 1 313 ? 33.110  30.294  16.089  1.00 79.57  ? 307 ALA C O   1 
ATOM 7788  C CB  . ALA C 1 313 ? 32.100  27.657  14.489  1.00 69.37  ? 307 ALA C CB  1 
ATOM 7789  N N   . ASP C 1 314 ? 31.541  29.121  17.178  1.00 69.51  ? 308 ASP C N   1 
ATOM 7790  C CA  . ASP C 1 314 ? 31.067  30.366  17.838  1.00 66.90  ? 308 ASP C CA  1 
ATOM 7791  C C   . ASP C 1 314 ? 31.745  30.526  19.195  1.00 66.47  ? 308 ASP C C   1 
ATOM 7792  O O   . ASP C 1 314 ? 31.528  31.568  19.820  1.00 73.85  ? 308 ASP C O   1 
ATOM 7793  C CB  . ASP C 1 314 ? 29.566  30.361  18.061  1.00 68.27  ? 308 ASP C CB  1 
ATOM 7794  C CG  . ASP C 1 314 ? 28.669  30.677  16.878  1.00 65.98  ? 308 ASP C CG  1 
ATOM 7795  O OD1 . ASP C 1 314 ? 29.129  31.364  15.958  1.00 54.80  ? 308 ASP C OD1 1 
ATOM 7796  O OD2 . ASP C 1 314 ? 27.507  30.246  16.912  1.00 71.56  ? 308 ASP C OD2 1 
ATOM 7797  N N   . PHE C 1 315 ? 32.573  29.575  19.613  1.00 60.31  ? 309 PHE C N   1 
ATOM 7798  C CA  . PHE C 1 315 ? 33.133  29.563  20.963  1.00 55.94  ? 309 PHE C CA  1 
ATOM 7799  C C   . PHE C 1 315 ? 34.650  29.367  21.019  1.00 52.51  ? 309 PHE C C   1 
ATOM 7800  O O   . PHE C 1 315 ? 35.212  29.493  22.106  1.00 46.61  ? 309 PHE C O   1 
ATOM 7801  C CB  . PHE C 1 315 ? 32.491  28.473  21.833  1.00 52.99  ? 309 PHE C CB  1 
ATOM 7802  C CG  . PHE C 1 315 ? 31.017  28.738  22.081  1.00 48.62  ? 309 PHE C CG  1 
ATOM 7803  C CD1 . PHE C 1 315 ? 30.616  29.789  22.883  1.00 44.37  ? 309 PHE C CD1 1 
ATOM 7804  C CD2 . PHE C 1 315 ? 30.040  27.970  21.468  1.00 52.47  ? 309 PHE C CD2 1 
ATOM 7805  C CE1 . PHE C 1 315 ? 29.273  30.052  23.069  1.00 49.64  ? 309 PHE C CE1 1 
ATOM 7806  C CE2 . PHE C 1 315 ? 28.693  28.234  21.667  1.00 53.91  ? 309 PHE C CE2 1 
ATOM 7807  C CZ  . PHE C 1 315 ? 28.311  29.274  22.469  1.00 50.94  ? 309 PHE C CZ  1 
ATOM 7808  N N   . VAL C 1 316 ? 35.291  28.933  19.942  1.00 54.96  ? 310 VAL C N   1 
ATOM 7809  C CA  . VAL C 1 316 ? 36.780  28.822  19.991  1.00 58.42  ? 310 VAL C CA  1 
ATOM 7810  C C   . VAL C 1 316 ? 37.353  29.505  18.747  1.00 69.64  ? 310 VAL C C   1 
ATOM 7811  O O   . VAL C 1 316 ? 38.336  30.249  18.900  1.00 69.28  ? 310 VAL C O   1 
ATOM 7812  C CB  . VAL C 1 316 ? 37.315  27.382  20.105  1.00 51.89  ? 310 VAL C CB  1 
ATOM 7813  C CG1 . VAL C 1 316 ? 38.812  27.348  20.360  1.00 47.36  ? 310 VAL C CG1 1 
ATOM 7814  C CG2 . VAL C 1 316 ? 36.571  26.578  21.158  1.00 55.14  ? 310 VAL C CG2 1 
ATOM 7815  N N   . GLU C 1 317 ? 36.835  29.169  17.567  1.00 75.06  ? 311 GLU C N   1 
ATOM 7816  C CA  . GLU C 1 317 ? 37.287  29.771  16.284  1.00 73.36  ? 311 GLU C CA  1 
ATOM 7817  C C   . GLU C 1 317 ? 37.027  31.277  16.166  1.00 62.07  ? 311 GLU C C   1 
ATOM 7818  O O   . GLU C 1 317 ? 37.934  31.990  15.731  1.00 53.39  ? 311 GLU C O   1 
ATOM 7819  C CB  . GLU C 1 317 ? 36.598  29.025  15.148  1.00 86.44  ? 311 GLU C CB  1 
ATOM 7820  C CG  . GLU C 1 317 ? 37.429  27.872  14.595  1.00 98.09  ? 311 GLU C CG  1 
ATOM 7821  C CD  . GLU C 1 317 ? 38.931  28.074  14.693  1.00 110.38 ? 311 GLU C CD  1 
ATOM 7822  O OE1 . GLU C 1 317 ? 39.478  28.881  13.911  1.00 108.93 ? 311 GLU C OE1 1 
ATOM 7823  O OE2 . GLU C 1 317 ? 39.556  27.415  15.548  1.00 118.80 ? 311 GLU C OE2 1 
ATOM 7824  N N   . SER C 1 318 ? 35.883  31.758  16.624  1.00 59.85  ? 312 SER C N   1 
ATOM 7825  C CA  . SER C 1 318 ? 35.499  33.162  16.345  1.00 63.11  ? 312 SER C CA  1 
ATOM 7826  C C   . SER C 1 318 ? 36.461  34.158  16.976  1.00 60.94  ? 312 SER C C   1 
ATOM 7827  O O   . SER C 1 318 ? 36.988  33.870  18.046  1.00 57.43  ? 312 SER C O   1 
ATOM 7828  C CB  . SER C 1 318 ? 34.097  33.431  16.821  1.00 65.19  ? 312 SER C CB  1 
ATOM 7829  O OG  . SER C 1 318 ? 33.476  34.471  16.080  1.00 58.49  ? 312 SER C OG  1 
ATOM 7830  N N   . LYS C 1 319 ? 36.728  35.249  16.270  1.00 68.66  ? 313 LYS C N   1 
ATOM 7831  C CA  . LYS C 1 319 ? 37.570  36.326  16.838  1.00 76.86  ? 313 LYS C CA  1 
ATOM 7832  C C   . LYS C 1 319 ? 36.632  37.350  17.470  1.00 76.25  ? 313 LYS C C   1 
ATOM 7833  O O   . LYS C 1 319 ? 36.951  38.549  17.427  1.00 80.90  ? 313 LYS C O   1 
ATOM 7834  C CB  . LYS C 1 319 ? 38.416  36.964  15.739  1.00 84.82  ? 313 LYS C CB  1 
ATOM 7835  C CG  . LYS C 1 319 ? 39.198  36.003  14.860  1.00 93.02  ? 313 LYS C CG  1 
ATOM 7836  C CD  . LYS C 1 319 ? 40.551  36.573  14.454  1.00 94.25  ? 313 LYS C CD  1 
ATOM 7837  C CE  . LYS C 1 319 ? 41.222  37.293  15.579  1.00 96.28  ? 313 LYS C CE  1 
ATOM 7838  N NZ  . LYS C 1 319 ? 42.678  37.149  15.517  1.00 97.87  ? 313 LYS C NZ  1 
ATOM 7839  N N   . ASP C 1 320 ? 35.520  36.882  18.027  1.00 72.69  ? 314 ASP C N   1 
ATOM 7840  C CA  . ASP C 1 320 ? 34.539  37.759  18.655  1.00 70.43  ? 314 ASP C CA  1 
ATOM 7841  C C   . ASP C 1 320 ? 34.225  37.363  20.099  1.00 64.23  ? 314 ASP C C   1 
ATOM 7842  O O   . ASP C 1 320 ? 33.342  37.967  20.722  1.00 56.73  ? 314 ASP C O   1 
ATOM 7843  C CB  . ASP C 1 320 ? 33.193  37.699  17.951  1.00 68.25  ? 314 ASP C CB  1 
ATOM 7844  C CG  . ASP C 1 320 ? 33.147  38.293  16.561  1.00 66.08  ? 314 ASP C CG  1 
ATOM 7845  O OD1 . ASP C 1 320 ? 34.222  38.720  16.090  1.00 72.73  ? 314 ASP C OD1 1 
ATOM 7846  O OD2 . ASP C 1 320 ? 32.028  38.344  16.004  1.00 62.45  ? 314 ASP C OD2 1 
ATOM 7847  N N   . VAL C 1 321 ? 34.928  36.353  20.628  1.00 55.80  ? 315 VAL C N   1 
ATOM 7848  C CA  . VAL C 1 321 ? 34.490  35.717  21.860  1.00 57.53  ? 315 VAL C CA  1 
ATOM 7849  C C   . VAL C 1 321 ? 34.522  36.750  22.990  1.00 52.70  ? 315 VAL C C   1 
ATOM 7850  O O   . VAL C 1 321 ? 33.577  36.885  23.753  1.00 54.93  ? 315 VAL C O   1 
ATOM 7851  C CB  . VAL C 1 321 ? 35.289  34.452  22.232  1.00 63.35  ? 315 VAL C CB  1 
ATOM 7852  C CG1 . VAL C 1 321 ? 34.721  33.784  23.482  1.00 68.91  ? 315 VAL C CG1 1 
ATOM 7853  C CG2 . VAL C 1 321 ? 35.346  33.436  21.097  1.00 62.95  ? 315 VAL C CG2 1 
ATOM 7854  N N   . CYS C 1 322 ? 35.610  37.500  23.088  1.00 51.26  ? 316 CYS C N   1 
ATOM 7855  C CA  . CYS C 1 322 ? 35.746  38.471  24.153  1.00 51.87  ? 316 CYS C CA  1 
ATOM 7856  C C   . CYS C 1 322 ? 34.721  39.586  23.970  1.00 52.59  ? 316 CYS C C   1 
ATOM 7857  O O   . CYS C 1 322 ? 34.198  40.090  24.955  1.00 71.22  ? 316 CYS C O   1 
ATOM 7858  C CB  . CYS C 1 322 ? 37.172  39.010  24.219  1.00 53.09  ? 316 CYS C CB  1 
ATOM 7859  S SG  . CYS C 1 322 ? 38.445  37.718  24.304  1.00 52.28  ? 316 CYS C SG  1 
ATOM 7860  N N   . LYS C 1 323 ? 34.456  39.988  22.726  1.00 51.50  ? 317 LYS C N   1 
ATOM 7861  C CA  . LYS C 1 323 ? 33.441  40.992  22.439  1.00 56.29  ? 317 LYS C CA  1 
ATOM 7862  C C   . LYS C 1 323 ? 32.041  40.460  22.766  1.00 62.83  ? 317 LYS C C   1 
ATOM 7863  O O   . LYS C 1 323 ? 31.154  41.236  23.128  1.00 64.33  ? 317 LYS C O   1 
ATOM 7864  C CB  . LYS C 1 323 ? 33.530  41.380  20.958  1.00 55.59  ? 317 LYS C CB  1 
ATOM 7865  C CG  . LYS C 1 323 ? 32.678  42.559  20.501  1.00 58.94  ? 317 LYS C CG  1 
ATOM 7866  C CD  . LYS C 1 323 ? 32.772  42.714  18.987  1.00 66.95  ? 317 LYS C CD  1 
ATOM 7867  C CE  . LYS C 1 323 ? 32.284  44.015  18.406  1.00 71.81  ? 317 LYS C CE  1 
ATOM 7868  N NZ  . LYS C 1 323 ? 32.745  44.181  17.015  1.00 71.34  ? 317 LYS C NZ  1 
ATOM 7869  N N   . ASN C 1 324 ? 31.846  39.138  22.613  1.00 60.75  ? 318 ASN C N   1 
ATOM 7870  C CA  . ASN C 1 324 ? 30.546  38.499  22.757  1.00 57.24  ? 318 ASN C CA  1 
ATOM 7871  C C   . ASN C 1 324 ? 30.266  38.035  24.181  1.00 58.27  ? 318 ASN C C   1 
ATOM 7872  O O   . ASN C 1 324 ? 29.107  37.898  24.554  1.00 57.49  ? 318 ASN C O   1 
ATOM 7873  C CB  . ASN C 1 324 ? 30.445  37.275  21.865  1.00 56.82  ? 318 ASN C CB  1 
ATOM 7874  C CG  . ASN C 1 324 ? 30.330  37.668  20.418  1.00 57.31  ? 318 ASN C CG  1 
ATOM 7875  O OD1 . ASN C 1 324 ? 31.069  37.159  19.569  1.00 57.48  ? 318 ASN C OD1 1 
ATOM 7876  N ND2 . ASN C 1 324 ? 29.380  38.539  20.124  1.00 57.97  ? 318 ASN C ND2 1 
ATOM 7877  N N   . TYR C 1 325 ? 31.335  37.740  24.931  1.00 69.90  ? 319 TYR C N   1 
ATOM 7878  C CA  . TYR C 1 325 ? 31.288  37.403  26.353  1.00 75.54  ? 319 TYR C CA  1 
ATOM 7879  C C   . TYR C 1 325 ? 31.071  38.651  27.220  1.00 74.71  ? 319 TYR C C   1 
ATOM 7880  O O   . TYR C 1 325 ? 30.271  38.637  28.160  1.00 66.92  ? 319 TYR C O   1 
ATOM 7881  C CB  . TYR C 1 325 ? 32.617  36.709  26.679  1.00 74.88  ? 319 TYR C CB  1 
ATOM 7882  C CG  . TYR C 1 325 ? 32.790  36.240  28.116  1.00 72.79  ? 319 TYR C CG  1 
ATOM 7883  C CD1 . TYR C 1 325 ? 31.780  35.552  28.774  1.00 74.18  ? 319 TYR C CD1 1 
ATOM 7884  C CD2 . TYR C 1 325 ? 33.971  36.482  28.807  1.00 72.99  ? 319 TYR C CD2 1 
ATOM 7885  C CE1 . TYR C 1 325 ? 31.937  35.123  30.081  1.00 78.91  ? 319 TYR C CE1 1 
ATOM 7886  C CE2 . TYR C 1 325 ? 34.139  36.061  30.114  1.00 75.73  ? 319 TYR C CE2 1 
ATOM 7887  C CZ  . TYR C 1 325 ? 33.118  35.383  30.755  1.00 82.39  ? 319 TYR C CZ  1 
ATOM 7888  O OH  . TYR C 1 325 ? 33.297  34.968  32.045  1.00 94.28  ? 319 TYR C OH  1 
ATOM 7889  N N   . ALA C 1 326 ? 31.743  39.731  26.865  1.00 72.75  ? 320 ALA C N   1 
ATOM 7890  C CA  . ALA C 1 326 ? 31.594  40.973  27.636  1.00 65.58  ? 320 ALA C CA  1 
ATOM 7891  C C   . ALA C 1 326 ? 30.146  41.436  27.610  1.00 65.70  ? 320 ALA C C   1 
ATOM 7892  O O   . ALA C 1 326 ? 29.662  41.885  28.660  1.00 73.04  ? 320 ALA C O   1 
ATOM 7893  C CB  . ALA C 1 326 ? 32.484  42.007  27.041  1.00 66.09  ? 320 ALA C CB  1 
ATOM 7894  N N   . GLU C 1 327 ? 29.502  41.421  26.447  1.00 65.17  ? 321 GLU C N   1 
ATOM 7895  C CA  . GLU C 1 327 ? 28.137  41.994  26.416  1.00 68.36  ? 321 GLU C CA  1 
ATOM 7896  C C   . GLU C 1 327 ? 27.166  41.220  27.308  1.00 61.60  ? 321 GLU C C   1 
ATOM 7897  O O   . GLU C 1 327 ? 26.337  41.878  27.943  1.00 59.91  ? 321 GLU C O   1 
ATOM 7898  C CB  . GLU C 1 327 ? 27.673  41.960  24.965  1.00 80.93  ? 321 GLU C CB  1 
ATOM 7899  C CG  . GLU C 1 327 ? 26.243  42.452  24.769  1.00 91.35  ? 321 GLU C CG  1 
ATOM 7900  C CD  . GLU C 1 327 ? 25.545  41.828  23.575  1.00 108.68 ? 321 GLU C CD  1 
ATOM 7901  O OE1 . GLU C 1 327 ? 26.247  41.209  22.750  1.00 122.90 ? 321 GLU C OE1 1 
ATOM 7902  O OE2 . GLU C 1 327 ? 24.307  41.957  23.471  1.00 114.20 ? 321 GLU C OE2 1 
ATOM 7903  N N   . ALA C 1 328 ? 27.197  39.894  27.303  1.00 56.99  ? 322 ALA C N   1 
ATOM 7904  C CA  . ALA C 1 328 ? 26.394  39.101  28.260  1.00 58.26  ? 322 ALA C CA  1 
ATOM 7905  C C   . ALA C 1 328 ? 27.225  37.986  28.879  1.00 60.11  ? 322 ALA C C   1 
ATOM 7906  O O   . ALA C 1 328 ? 26.934  36.838  28.541  1.00 62.60  ? 322 ALA C O   1 
ATOM 7907  C CB  . ALA C 1 328 ? 25.200  38.542  27.567  1.00 56.57  ? 322 ALA C CB  1 
ATOM 7908  N N   . LYS C 1 329 ? 28.165  38.253  29.760  1.00 58.19  ? 323 LYS C N   1 
ATOM 7909  C CA  . LYS C 1 329 ? 28.976  37.113  30.245  1.00 55.43  ? 323 LYS C CA  1 
ATOM 7910  C C   . LYS C 1 329 ? 28.089  35.890  30.503  1.00 56.53  ? 323 LYS C C   1 
ATOM 7911  O O   . LYS C 1 329 ? 28.455  34.820  30.007  1.00 51.91  ? 323 LYS C O   1 
ATOM 7912  C CB  . LYS C 1 329 ? 29.754  37.549  31.488  1.00 54.90  ? 323 LYS C CB  1 
ATOM 7913  C CG  . LYS C 1 329 ? 30.951  38.442  31.220  1.00 59.84  ? 323 LYS C CG  1 
ATOM 7914  C CD  . LYS C 1 329 ? 31.841  38.641  32.438  1.00 66.13  ? 323 LYS C CD  1 
ATOM 7915  C CE  . LYS C 1 329 ? 33.189  39.170  32.080  1.00 67.82  ? 323 LYS C CE  1 
ATOM 7916  N NZ  . LYS C 1 329 ? 33.190  40.629  31.978  1.00 72.39  ? 323 LYS C NZ  1 
ATOM 7917  N N   . ASP C 1 330 ? 26.943  36.042  31.167  1.00 56.39  ? 324 ASP C N   1 
ATOM 7918  C CA  . ASP C 1 330 ? 26.121  34.923  31.616  1.00 50.53  ? 324 ASP C CA  1 
ATOM 7919  C C   . ASP C 1 330 ? 25.354  34.326  30.435  1.00 50.44  ? 324 ASP C C   1 
ATOM 7920  O O   . ASP C 1 330 ? 25.488  33.130  30.170  1.00 48.27  ? 324 ASP C O   1 
ATOM 7921  C CB  . ASP C 1 330 ? 25.211  35.279  32.789  1.00 49.46  ? 324 ASP C CB  1 
ATOM 7922  C CG  . ASP C 1 330 ? 25.772  35.099  34.195  1.00 45.54  ? 324 ASP C CG  1 
ATOM 7923  O OD1 . ASP C 1 330 ? 26.988  34.822  34.318  1.00 48.42  ? 324 ASP C OD1 1 
ATOM 7924  O OD2 . ASP C 1 330 ? 24.984  35.230  35.161  1.00 41.02  ? 324 ASP C OD2 1 
ATOM 7925  N N   . VAL C 1 331 ? 24.580  35.138  29.696  1.00 46.38  ? 325 VAL C N   1 
ATOM 7926  C CA  . VAL C 1 331 ? 23.825  34.570  28.586  1.00 45.86  ? 325 VAL C CA  1 
ATOM 7927  C C   . VAL C 1 331 ? 24.792  33.938  27.583  1.00 45.27  ? 325 VAL C C   1 
ATOM 7928  O O   . VAL C 1 331 ? 24.427  33.021  26.859  1.00 48.55  ? 325 VAL C O   1 
ATOM 7929  C CB  . VAL C 1 331 ? 22.831  35.541  27.924  1.00 43.94  ? 325 VAL C CB  1 
ATOM 7930  C CG1 . VAL C 1 331 ? 22.239  35.002  26.633  1.00 40.34  ? 325 VAL C CG1 1 
ATOM 7931  C CG2 . VAL C 1 331 ? 21.690  35.855  28.882  1.00 48.83  ? 325 VAL C CG2 1 
ATOM 7932  N N   . PHE C 1 332 ? 26.056  34.359  27.601  1.00 48.06  ? 326 PHE C N   1 
ATOM 7933  C CA  . PHE C 1 332 ? 27.069  33.740  26.764  1.00 50.00  ? 326 PHE C CA  1 
ATOM 7934  C C   . PHE C 1 332 ? 27.370  32.326  27.244  1.00 50.00  ? 326 PHE C C   1 
ATOM 7935  O O   . PHE C 1 332 ? 27.161  31.365  26.506  1.00 52.81  ? 326 PHE C O   1 
ATOM 7936  C CB  . PHE C 1 332 ? 28.382  34.525  26.734  1.00 50.34  ? 326 PHE C CB  1 
ATOM 7937  C CG  . PHE C 1 332 ? 29.259  34.115  25.562  1.00 49.55  ? 326 PHE C CG  1 
ATOM 7938  C CD1 . PHE C 1 332 ? 28.890  34.423  24.256  1.00 45.42  ? 326 PHE C CD1 1 
ATOM 7939  C CD2 . PHE C 1 332 ? 30.444  33.428  25.766  1.00 48.98  ? 326 PHE C CD2 1 
ATOM 7940  C CE1 . PHE C 1 332 ? 29.687  34.063  23.188  1.00 42.32  ? 326 PHE C CE1 1 
ATOM 7941  C CE2 . PHE C 1 332 ? 31.246  33.083  24.689  1.00 47.63  ? 326 PHE C CE2 1 
ATOM 7942  C CZ  . PHE C 1 332 ? 30.862  33.395  23.407  1.00 44.10  ? 326 PHE C CZ  1 
ATOM 7943  N N   . LEU C 1 333 ? 27.882  32.215  28.475  1.00 48.92  ? 327 LEU C N   1 
ATOM 7944  C CA  . LEU C 1 333 ? 28.235  30.920  29.037  1.00 45.89  ? 327 LEU C CA  1 
ATOM 7945  C C   . LEU C 1 333 ? 27.015  30.005  29.037  1.00 42.97  ? 327 LEU C C   1 
ATOM 7946  O O   . LEU C 1 333 ? 27.124  28.845  28.648  1.00 35.81  ? 327 LEU C O   1 
ATOM 7947  C CB  . LEU C 1 333 ? 28.809  31.114  30.435  1.00 44.08  ? 327 LEU C CB  1 
ATOM 7948  C CG  . LEU C 1 333 ? 30.197  31.760  30.472  1.00 48.42  ? 327 LEU C CG  1 
ATOM 7949  C CD1 . LEU C 1 333 ? 30.693  32.045  31.882  1.00 49.38  ? 327 LEU C CD1 1 
ATOM 7950  C CD2 . LEU C 1 333 ? 31.196  30.875  29.738  1.00 50.32  ? 327 LEU C CD2 1 
ATOM 7951  N N   . GLY C 1 334 ? 25.857  30.564  29.428  1.00 45.09  ? 328 GLY C N   1 
ATOM 7952  C CA  . GLY C 1 334 ? 24.576  29.873  29.380  1.00 44.46  ? 328 GLY C CA  1 
ATOM 7953  C C   . GLY C 1 334 ? 24.382  29.197  28.031  1.00 47.99  ? 328 GLY C C   1 
ATOM 7954  O O   . GLY C 1 334 ? 24.095  28.008  27.975  1.00 53.78  ? 328 GLY C O   1 
ATOM 7955  N N   . MET C 1 335 ? 24.604  29.954  26.953  1.00 49.44  ? 329 MET C N   1 
ATOM 7956  C CA  . MET C 1 335 ? 24.478  29.416  25.611  1.00 51.07  ? 329 MET C CA  1 
ATOM 7957  C C   . MET C 1 335 ? 25.558  28.367  25.357  1.00 50.85  ? 329 MET C C   1 
ATOM 7958  O O   . MET C 1 335 ? 25.247  27.285  24.862  1.00 56.17  ? 329 MET C O   1 
ATOM 7959  C CB  . MET C 1 335 ? 24.498  30.531  24.563  1.00 52.47  ? 329 MET C CB  1 
ATOM 7960  C CG  . MET C 1 335 ? 23.136  31.161  24.397  1.00 56.22  ? 329 MET C CG  1 
ATOM 7961  S SD  . MET C 1 335 ? 23.002  32.095  22.867  1.00 83.91  ? 329 MET C SD  1 
ATOM 7962  C CE  . MET C 1 335 ? 22.889  30.775  21.649  1.00 95.91  ? 329 MET C CE  1 
ATOM 7963  N N   . PHE C 1 336 ? 26.805  28.666  25.740  1.00 47.21  ? 330 PHE C N   1 
ATOM 7964  C CA  . PHE C 1 336 ? 27.897  27.709  25.604  1.00 47.48  ? 330 PHE C CA  1 
ATOM 7965  C C   . PHE C 1 336 ? 27.487  26.340  26.159  1.00 47.90  ? 330 PHE C C   1 
ATOM 7966  O O   . PHE C 1 336 ? 27.572  25.321  25.476  1.00 52.40  ? 330 PHE C O   1 
ATOM 7967  C CB  . PHE C 1 336 ? 29.165  28.233  26.290  1.00 44.49  ? 330 PHE C CB  1 
ATOM 7968  C CG  . PHE C 1 336 ? 30.253  27.178  26.415  1.00 41.71  ? 330 PHE C CG  1 
ATOM 7969  C CD1 . PHE C 1 336 ? 31.071  26.864  25.341  1.00 41.86  ? 330 PHE C CD1 1 
ATOM 7970  C CD2 . PHE C 1 336 ? 30.425  26.469  27.598  1.00 41.39  ? 330 PHE C CD2 1 
ATOM 7971  C CE1 . PHE C 1 336 ? 32.056  25.888  25.471  1.00 45.72  ? 330 PHE C CE1 1 
ATOM 7972  C CE2 . PHE C 1 336 ? 31.398  25.488  27.716  1.00 39.97  ? 330 PHE C CE2 1 
ATOM 7973  C CZ  . PHE C 1 336 ? 32.219  25.200  26.655  1.00 41.38  ? 330 PHE C CZ  1 
ATOM 7974  N N   . LEU C 1 337 ? 27.025  26.325  27.406  1.00 44.97  ? 331 LEU C N   1 
ATOM 7975  C CA  . LEU C 1 337 ? 26.670  25.094  28.088  1.00 48.26  ? 331 LEU C CA  1 
ATOM 7976  C C   . LEU C 1 337 ? 25.463  24.429  27.425  1.00 46.71  ? 331 LEU C C   1 
ATOM 7977  O O   . LEU C 1 337 ? 25.400  23.207  27.381  1.00 51.57  ? 331 LEU C O   1 
ATOM 7978  C CB  . LEU C 1 337 ? 26.401  25.482  29.541  1.00 53.97  ? 331 LEU C CB  1 
ATOM 7979  C CG  . LEU C 1 337 ? 25.944  24.374  30.491  1.00 57.89  ? 331 LEU C CG  1 
ATOM 7980  C CD1 . LEU C 1 337 ? 27.025  23.338  30.726  1.00 59.61  ? 331 LEU C CD1 1 
ATOM 7981  C CD2 . LEU C 1 337 ? 25.483  24.997  31.799  1.00 56.80  ? 331 LEU C CD2 1 
ATOM 7982  N N   . TYR C 1 338 ? 24.510  25.233  26.937  1.00 42.20  ? 332 TYR C N   1 
ATOM 7983  C CA  . TYR C 1 338 ? 23.382  24.738  26.169  1.00 44.47  ? 332 TYR C CA  1 
ATOM 7984  C C   . TYR C 1 338 ? 23.864  23.966  24.947  1.00 47.70  ? 332 TYR C C   1 
ATOM 7985  O O   . TYR C 1 338 ? 23.399  22.849  24.687  1.00 46.17  ? 332 TYR C O   1 
ATOM 7986  C CB  . TYR C 1 338 ? 22.528  25.923  25.723  1.00 47.90  ? 332 TYR C CB  1 
ATOM 7987  C CG  . TYR C 1 338 ? 21.535  25.706  24.583  1.00 56.41  ? 332 TYR C CG  1 
ATOM 7988  C CD1 . TYR C 1 338 ? 20.223  25.296  24.825  1.00 61.73  ? 332 TYR C CD1 1 
ATOM 7989  C CD2 . TYR C 1 338 ? 21.876  25.997  23.265  1.00 54.37  ? 332 TYR C CD2 1 
ATOM 7990  C CE1 . TYR C 1 338 ? 19.297  25.163  23.797  1.00 62.03  ? 332 TYR C CE1 1 
ATOM 7991  C CE2 . TYR C 1 338 ? 20.960  25.865  22.230  1.00 56.47  ? 332 TYR C CE2 1 
ATOM 7992  C CZ  . TYR C 1 338 ? 19.665  25.450  22.493  1.00 59.13  ? 332 TYR C CZ  1 
ATOM 7993  O OH  . TYR C 1 338 ? 18.757  25.314  21.479  1.00 55.41  ? 332 TYR C OH  1 
ATOM 7994  N N   . GLU C 1 339 ? 24.784  24.586  24.196  1.00 49.20  ? 333 GLU C N   1 
ATOM 7995  C CA  . GLU C 1 339 ? 25.289  23.995  22.966  1.00 53.00  ? 333 GLU C CA  1 
ATOM 7996  C C   . GLU C 1 339 ? 26.006  22.679  23.278  1.00 50.23  ? 333 GLU C C   1 
ATOM 7997  O O   . GLU C 1 339 ? 25.744  21.654  22.660  1.00 50.06  ? 333 GLU C O   1 
ATOM 7998  C CB  . GLU C 1 339 ? 26.190  24.966  22.204  1.00 56.79  ? 333 GLU C CB  1 
ATOM 7999  C CG  . GLU C 1 339 ? 25.439  26.150  21.595  1.00 64.04  ? 333 GLU C CG  1 
ATOM 8000  C CD  . GLU C 1 339 ? 24.554  25.935  20.365  1.00 68.09  ? 333 GLU C CD  1 
ATOM 8001  O OE1 . GLU C 1 339 ? 24.470  24.853  19.739  1.00 60.30  ? 333 GLU C OE1 1 
ATOM 8002  O OE2 . GLU C 1 339 ? 23.923  26.953  20.019  1.00 77.06  ? 333 GLU C OE2 1 
ATOM 8003  N N   . TYR C 1 340 ? 26.897  22.696  24.264  1.00 44.39  ? 334 TYR C N   1 
ATOM 8004  C CA  . TYR C 1 340 ? 27.606  21.490  24.644  1.00 42.00  ? 334 TYR C CA  1 
ATOM 8005  C C   . TYR C 1 340 ? 26.639  20.384  25.047  1.00 42.81  ? 334 TYR C C   1 
ATOM 8006  O O   . TYR C 1 340 ? 26.855  19.227  24.706  1.00 43.16  ? 334 TYR C O   1 
ATOM 8007  C CB  . TYR C 1 340 ? 28.494  21.802  25.842  1.00 42.21  ? 334 TYR C CB  1 
ATOM 8008  C CG  . TYR C 1 340 ? 29.864  21.154  25.760  1.00 41.80  ? 334 TYR C CG  1 
ATOM 8009  C CD1 . TYR C 1 340 ? 30.021  19.904  25.198  1.00 37.33  ? 334 TYR C CD1 1 
ATOM 8010  C CD2 . TYR C 1 340 ? 31.003  21.824  26.212  1.00 44.15  ? 334 TYR C CD2 1 
ATOM 8011  C CE1 . TYR C 1 340 ? 31.274  19.326  25.120  1.00 41.39  ? 334 TYR C CE1 1 
ATOM 8012  C CE2 . TYR C 1 340 ? 32.262  21.258  26.132  1.00 41.72  ? 334 TYR C CE2 1 
ATOM 8013  C CZ  . TYR C 1 340 ? 32.395  19.992  25.588  1.00 41.29  ? 334 TYR C CZ  1 
ATOM 8014  O OH  . TYR C 1 340 ? 33.602  19.350  25.491  1.00 37.52  ? 334 TYR C OH  1 
ATOM 8015  N N   . ALA C 1 341 ? 25.588  20.758  25.787  1.00 45.97  ? 335 ALA C N   1 
ATOM 8016  C CA  . ALA C 1 341 ? 24.668  19.809  26.399  1.00 45.99  ? 335 ALA C CA  1 
ATOM 8017  C C   . ALA C 1 341 ? 23.803  19.126  25.348  1.00 45.92  ? 335 ALA C C   1 
ATOM 8018  O O   . ALA C 1 341 ? 23.628  17.921  25.418  1.00 49.62  ? 335 ALA C O   1 
ATOM 8019  C CB  . ALA C 1 341 ? 23.797  20.488  27.435  1.00 47.67  ? 335 ALA C CB  1 
ATOM 8020  N N   . ARG C 1 342 ? 23.238  19.874  24.395  1.00 46.67  ? 336 ARG C N   1 
ATOM 8021  C CA  . ARG C 1 342 ? 22.407  19.243  23.371  1.00 53.05  ? 336 ARG C CA  1 
ATOM 8022  C C   . ARG C 1 342 ? 23.216  18.172  22.618  1.00 51.66  ? 336 ARG C C   1 
ATOM 8023  O O   . ARG C 1 342 ? 22.694  17.119  22.221  1.00 48.93  ? 336 ARG C O   1 
ATOM 8024  C CB  . ARG C 1 342 ? 21.768  20.316  22.472  1.00 54.68  ? 336 ARG C CB  1 
ATOM 8025  C CG  . ARG C 1 342 ? 22.699  21.111  21.573  1.00 52.56  ? 336 ARG C CG  1 
ATOM 8026  C CD  . ARG C 1 342 ? 22.159  22.497  21.289  1.00 54.89  ? 336 ARG C CD  1 
ATOM 8027  N NE  . ARG C 1 342 ? 20.913  22.526  20.510  1.00 55.90  ? 336 ARG C NE  1 
ATOM 8028  C CZ  . ARG C 1 342 ? 20.623  23.392  19.524  1.00 56.76  ? 336 ARG C CZ  1 
ATOM 8029  N NH1 . ARG C 1 342 ? 21.521  24.260  19.073  1.00 55.50  ? 336 ARG C NH1 1 
ATOM 8030  N NH2 . ARG C 1 342 ? 19.420  23.387  18.972  1.00 57.11  ? 336 ARG C NH2 1 
ATOM 8031  N N   . ARG C 1 343 ? 24.521  18.440  22.480  1.00 48.06  ? 337 ARG C N   1 
ATOM 8032  C CA  . ARG C 1 343 ? 25.437  17.588  21.745  1.00 46.99  ? 337 ARG C CA  1 
ATOM 8033  C C   . ARG C 1 343 ? 25.898  16.392  22.575  1.00 44.40  ? 337 ARG C C   1 
ATOM 8034  O O   . ARG C 1 343 ? 26.368  15.420  22.018  1.00 47.02  ? 337 ARG C O   1 
ATOM 8035  C CB  . ARG C 1 343 ? 26.648  18.406  21.271  1.00 48.98  ? 337 ARG C CB  1 
ATOM 8036  C CG  . ARG C 1 343 ? 26.392  19.320  20.075  1.00 47.03  ? 337 ARG C CG  1 
ATOM 8037  C CD  . ARG C 1 343 ? 27.546  20.285  19.865  1.00 46.99  ? 337 ARG C CD  1 
ATOM 8038  N NE  . ARG C 1 343 ? 27.407  21.186  18.715  1.00 48.64  ? 337 ARG C NE  1 
ATOM 8039  C CZ  . ARG C 1 343 ? 26.530  22.171  18.594  1.00 54.82  ? 337 ARG C CZ  1 
ATOM 8040  N NH1 . ARG C 1 343 ? 25.636  22.389  19.536  1.00 57.50  ? 337 ARG C NH1 1 
ATOM 8041  N NH2 . ARG C 1 343 ? 26.540  22.949  17.525  1.00 64.24  ? 337 ARG C NH2 1 
ATOM 8042  N N   . HIS C 1 344 ? 25.814  16.442  23.901  1.00 49.45  ? 338 HIS C N   1 
ATOM 8043  C CA  . HIS C 1 344 ? 26.320  15.330  24.694  1.00 55.15  ? 338 HIS C CA  1 
ATOM 8044  C C   . HIS C 1 344 ? 25.319  14.829  25.733  1.00 60.98  ? 338 HIS C C   1 
ATOM 8045  O O   . HIS C 1 344 ? 25.571  14.985  26.929  1.00 65.20  ? 338 HIS C O   1 
ATOM 8046  C CB  . HIS C 1 344 ? 27.649  15.713  25.353  1.00 52.39  ? 338 HIS C CB  1 
ATOM 8047  C CG  . HIS C 1 344 ? 28.735  15.737  24.347  1.00 51.63  ? 338 HIS C CG  1 
ATOM 8048  N ND1 . HIS C 1 344 ? 29.715  14.771  24.299  1.00 51.25  ? 338 HIS C ND1 1 
ATOM 8049  C CD2 . HIS C 1 344 ? 28.970  16.578  23.331  1.00 48.38  ? 338 HIS C CD2 1 
ATOM 8050  C CE1 . HIS C 1 344 ? 30.531  15.041  23.290  1.00 50.93  ? 338 HIS C CE1 1 
ATOM 8051  N NE2 . HIS C 1 344 ? 30.099  16.135  22.693  1.00 50.48  ? 338 HIS C NE2 1 
ATOM 8052  N N   . PRO C 1 345 ? 24.196  14.175  25.331  1.00 62.65  ? 339 PRO C N   1 
ATOM 8053  C CA  . PRO C 1 345 ? 23.415  13.356  26.260  1.00 62.63  ? 339 PRO C CA  1 
ATOM 8054  C C   . PRO C 1 345 ? 24.266  12.393  27.085  1.00 71.06  ? 339 PRO C C   1 
ATOM 8055  O O   . PRO C 1 345 ? 23.894  12.072  28.215  1.00 81.71  ? 339 PRO C O   1 
ATOM 8056  C CB  . PRO C 1 345 ? 22.456  12.631  25.316  1.00 58.72  ? 339 PRO C CB  1 
ATOM 8057  C CG  . PRO C 1 345 ? 22.171  13.687  24.269  1.00 65.47  ? 339 PRO C CG  1 
ATOM 8058  C CD  . PRO C 1 345 ? 23.565  14.249  24.000  1.00 66.19  ? 339 PRO C CD  1 
ATOM 8059  N N   . ASP C 1 346 ? 25.425  11.986  26.536  1.00 66.88  ? 340 ASP C N   1 
ATOM 8060  C CA  . ASP C 1 346 ? 26.224  10.910  27.106  1.00 64.91  ? 340 ASP C CA  1 
ATOM 8061  C C   . ASP C 1 346 ? 27.047  11.388  28.306  1.00 66.48  ? 340 ASP C C   1 
ATOM 8062  O O   . ASP C 1 346 ? 27.659  10.570  29.003  1.00 73.20  ? 340 ASP C O   1 
ATOM 8063  C CB  . ASP C 1 346 ? 27.103  10.259  26.048  1.00 60.95  ? 340 ASP C CB  1 
ATOM 8064  C CG  . ASP C 1 346 ? 28.396  10.991  25.726  1.00 62.10  ? 340 ASP C CG  1 
ATOM 8065  O OD1 . ASP C 1 346 ? 28.313  12.027  25.027  1.00 56.63  ? 340 ASP C OD1 1 
ATOM 8066  O OD2 . ASP C 1 346 ? 29.470  10.531  26.218  1.00 61.76  ? 340 ASP C OD2 1 
ATOM 8067  N N   . TYR C 1 347 ? 27.069  12.705  28.540  1.00 57.09  ? 341 TYR C N   1 
ATOM 8068  C CA  . TYR C 1 347 ? 27.864  13.273  29.615  1.00 60.07  ? 341 TYR C CA  1 
ATOM 8069  C C   . TYR C 1 347 ? 27.015  13.408  30.878  1.00 58.38  ? 341 TYR C C   1 
ATOM 8070  O O   . TYR C 1 347 ? 25.815  13.663  30.788  1.00 56.17  ? 341 TYR C O   1 
ATOM 8071  C CB  . TYR C 1 347 ? 28.397  14.636  29.165  1.00 62.88  ? 341 TYR C CB  1 
ATOM 8072  C CG  . TYR C 1 347 ? 29.553  14.654  28.169  1.00 59.91  ? 341 TYR C CG  1 
ATOM 8073  C CD1 . TYR C 1 347 ? 30.022  13.506  27.548  1.00 64.28  ? 341 TYR C CD1 1 
ATOM 8074  C CD2 . TYR C 1 347 ? 30.157  15.852  27.828  1.00 55.38  ? 341 TYR C CD2 1 
ATOM 8075  C CE1 . TYR C 1 347 ? 31.068  13.551  26.640  1.00 64.35  ? 341 TYR C CE1 1 
ATOM 8076  C CE2 . TYR C 1 347 ? 31.205  15.911  26.932  1.00 55.78  ? 341 TYR C CE2 1 
ATOM 8077  C CZ  . TYR C 1 347 ? 31.666  14.759  26.335  1.00 59.57  ? 341 TYR C CZ  1 
ATOM 8078  O OH  . TYR C 1 347 ? 32.695  14.853  25.444  1.00 62.85  ? 341 TYR C OH  1 
ATOM 8079  N N   . SER C 1 348 ? 27.662  13.258  32.047  1.00 56.03  ? 342 SER C N   1 
ATOM 8080  C CA  . SER C 1 348 ? 27.052  13.654  33.308  1.00 52.77  ? 342 SER C CA  1 
ATOM 8081  C C   . SER C 1 348 ? 26.906  15.175  33.313  1.00 54.95  ? 342 SER C C   1 
ATOM 8082  O O   . SER C 1 348 ? 27.740  15.900  32.771  1.00 58.08  ? 342 SER C O   1 
ATOM 8083  C CB  . SER C 1 348 ? 27.783  13.143  34.566  1.00 47.49  ? 342 SER C CB  1 
ATOM 8084  O OG  . SER C 1 348 ? 29.141  13.549  34.659  1.00 48.19  ? 342 SER C OG  1 
ATOM 8085  N N   . VAL C 1 349 ? 25.820  15.638  33.932  1.00 52.47  ? 343 VAL C N   1 
ATOM 8086  C CA  . VAL C 1 349 ? 25.528  17.052  34.050  1.00 47.13  ? 343 VAL C CA  1 
ATOM 8087  C C   . VAL C 1 349 ? 26.619  17.753  34.859  1.00 48.08  ? 343 VAL C C   1 
ATOM 8088  O O   . VAL C 1 349 ? 26.874  18.936  34.640  1.00 49.12  ? 343 VAL C O   1 
ATOM 8089  C CB  . VAL C 1 349 ? 24.125  17.200  34.664  1.00 42.63  ? 343 VAL C CB  1 
ATOM 8090  C CG1 . VAL C 1 349 ? 23.743  18.653  34.867  1.00 43.91  ? 343 VAL C CG1 1 
ATOM 8091  C CG2 . VAL C 1 349 ? 23.082  16.543  33.779  1.00 44.58  ? 343 VAL C CG2 1 
ATOM 8092  N N   . VAL C 1 350 ? 27.280  17.028  35.771  1.00 48.84  ? 344 VAL C N   1 
ATOM 8093  C CA  . VAL C 1 350 ? 28.390  17.590  36.532  1.00 52.35  ? 344 VAL C CA  1 
ATOM 8094  C C   . VAL C 1 350 ? 29.607  17.753  35.613  1.00 51.63  ? 344 VAL C C   1 
ATOM 8095  O O   . VAL C 1 350 ? 30.386  18.683  35.784  1.00 50.11  ? 344 VAL C O   1 
ATOM 8096  C CB  . VAL C 1 350 ? 28.791  16.796  37.794  1.00 57.38  ? 344 VAL C CB  1 
ATOM 8097  C CG1 . VAL C 1 350 ? 27.602  16.140  38.490  1.00 59.97  ? 344 VAL C CG1 1 
ATOM 8098  C CG2 . VAL C 1 350 ? 29.859  15.752  37.492  1.00 59.60  ? 344 VAL C CG2 1 
ATOM 8099  N N   . LEU C 1 351 ? 29.799  16.837  34.656  1.00 52.01  ? 345 LEU C N   1 
ATOM 8100  C CA  . LEU C 1 351 ? 30.884  16.967  33.695  1.00 56.51  ? 345 LEU C CA  1 
ATOM 8101  C C   . LEU C 1 351 ? 30.704  18.247  32.863  1.00 57.48  ? 345 LEU C C   1 
ATOM 8102  O O   . LEU C 1 351 ? 31.636  19.037  32.709  1.00 61.19  ? 345 LEU C O   1 
ATOM 8103  C CB  . LEU C 1 351 ? 30.988  15.718  32.817  1.00 55.52  ? 345 LEU C CB  1 
ATOM 8104  C CG  . LEU C 1 351 ? 32.070  15.753  31.730  1.00 59.82  ? 345 LEU C CG  1 
ATOM 8105  C CD1 . LEU C 1 351 ? 33.476  15.885  32.280  1.00 60.38  ? 345 LEU C CD1 1 
ATOM 8106  C CD2 . LEU C 1 351 ? 32.006  14.529  30.852  1.00 65.57  ? 345 LEU C CD2 1 
ATOM 8107  N N   . LEU C 1 352 ? 29.501  18.458  32.324  1.00 52.56  ? 346 LEU C N   1 
ATOM 8108  C CA  . LEU C 1 352 ? 29.175  19.682  31.598  1.00 53.14  ? 346 LEU C CA  1 
ATOM 8109  C C   . LEU C 1 352 ? 29.525  20.956  32.389  1.00 53.21  ? 346 LEU C C   1 
ATOM 8110  O O   . LEU C 1 352 ? 30.075  21.934  31.844  1.00 41.23  ? 346 LEU C O   1 
ATOM 8111  C CB  . LEU C 1 352 ? 27.680  19.631  31.284  1.00 52.58  ? 346 LEU C CB  1 
ATOM 8112  C CG  . LEU C 1 352 ? 27.257  18.680  30.165  1.00 53.98  ? 346 LEU C CG  1 
ATOM 8113  C CD1 . LEU C 1 352 ? 25.782  18.885  29.889  1.00 60.79  ? 346 LEU C CD1 1 
ATOM 8114  C CD2 . LEU C 1 352 ? 28.069  18.888  28.902  1.00 51.73  ? 346 LEU C CD2 1 
ATOM 8115  N N   . LEU C 1 353 ? 29.136  20.964  33.671  1.00 50.87  ? 347 LEU C N   1 
ATOM 8116  C CA  . LEU C 1 353 ? 29.374  22.114  34.519  1.00 50.08  ? 347 LEU C CA  1 
ATOM 8117  C C   . LEU C 1 353 ? 30.879  22.253  34.728  1.00 50.76  ? 347 LEU C C   1 
ATOM 8118  O O   . LEU C 1 353 ? 31.402  23.353  34.630  1.00 59.33  ? 347 LEU C O   1 
ATOM 8119  C CB  . LEU C 1 353 ? 28.602  22.046  35.837  1.00 51.78  ? 347 LEU C CB  1 
ATOM 8120  C CG  . LEU C 1 353 ? 27.068  22.099  35.745  1.00 55.70  ? 347 LEU C CG  1 
ATOM 8121  C CD1 . LEU C 1 353 ? 26.427  22.423  37.101  1.00 55.73  ? 347 LEU C CD1 1 
ATOM 8122  C CD2 . LEU C 1 353 ? 26.566  23.089  34.709  1.00 55.89  ? 347 LEU C CD2 1 
ATOM 8123  N N   . ARG C 1 354 ? 31.593  21.148  34.949  1.00 49.13  ? 348 ARG C N   1 
ATOM 8124  C CA  . ARG C 1 354 ? 33.040  21.226  35.086  1.00 53.76  ? 348 ARG C CA  1 
ATOM 8125  C C   . ARG C 1 354 ? 33.649  21.908  33.854  1.00 51.64  ? 348 ARG C C   1 
ATOM 8126  O O   . ARG C 1 354 ? 34.621  22.661  33.963  1.00 44.87  ? 348 ARG C O   1 
ATOM 8127  C CB  . ARG C 1 354 ? 33.690  19.848  35.285  1.00 55.60  ? 348 ARG C CB  1 
ATOM 8128  C CG  . ARG C 1 354 ? 33.320  19.114  36.564  1.00 56.65  ? 348 ARG C CG  1 
ATOM 8129  C CD  . ARG C 1 354 ? 34.080  17.805  36.680  1.00 59.03  ? 348 ARG C CD  1 
ATOM 8130  N NE  . ARG C 1 354 ? 33.375  16.774  37.455  1.00 56.15  ? 348 ARG C NE  1 
ATOM 8131  C CZ  . ARG C 1 354 ? 33.097  15.563  37.007  1.00 62.56  ? 348 ARG C CZ  1 
ATOM 8132  N NH1 . ARG C 1 354 ? 33.363  15.243  35.752  1.00 71.28  ? 348 ARG C NH1 1 
ATOM 8133  N NH2 . ARG C 1 354 ? 32.546  14.667  37.806  1.00 61.81  ? 348 ARG C NH2 1 
ATOM 8134  N N   . LEU C 1 355 ? 33.093  21.610  32.674  1.00 46.22  ? 349 LEU C N   1 
ATOM 8135  C CA  . LEU C 1 355 ? 33.582  22.203  31.445  1.00 48.59  ? 349 LEU C CA  1 
ATOM 8136  C C   . LEU C 1 355 ? 33.222  23.690  31.414  1.00 49.05  ? 349 LEU C C   1 
ATOM 8137  O O   . LEU C 1 355 ? 34.090  24.543  31.198  1.00 43.87  ? 349 LEU C O   1 
ATOM 8138  C CB  . LEU C 1 355 ? 33.003  21.451  30.248  1.00 51.32  ? 349 LEU C CB  1 
ATOM 8139  C CG  . LEU C 1 355 ? 33.429  19.986  30.100  1.00 51.20  ? 349 LEU C CG  1 
ATOM 8140  C CD1 . LEU C 1 355 ? 32.550  19.253  29.089  1.00 49.89  ? 349 LEU C CD1 1 
ATOM 8141  C CD2 . LEU C 1 355 ? 34.892  19.902  29.704  1.00 50.85  ? 349 LEU C CD2 1 
ATOM 8142  N N   . ALA C 1 356 ? 31.931  24.000  31.603  1.00 48.22  ? 350 ALA C N   1 
ATOM 8143  C CA  . ALA C 1 356 ? 31.495  25.386  31.525  1.00 47.67  ? 350 ALA C CA  1 
ATOM 8144  C C   . ALA C 1 356 ? 32.387  26.241  32.431  1.00 47.23  ? 350 ALA C C   1 
ATOM 8145  O O   . ALA C 1 356 ? 32.907  27.272  32.015  1.00 42.77  ? 350 ALA C O   1 
ATOM 8146  C CB  . ALA C 1 356 ? 30.020  25.497  31.857  1.00 43.77  ? 350 ALA C CB  1 
ATOM 8147  N N   . LYS C 1 357 ? 32.619  25.752  33.649  1.00 49.75  ? 351 LYS C N   1 
ATOM 8148  C CA  . LYS C 1 357 ? 33.422  26.445  34.641  1.00 59.27  ? 351 LYS C CA  1 
ATOM 8149  C C   . LYS C 1 357 ? 34.829  26.686  34.086  1.00 62.93  ? 351 LYS C C   1 
ATOM 8150  O O   . LYS C 1 357 ? 35.345  27.795  34.215  1.00 63.56  ? 351 LYS C O   1 
ATOM 8151  C CB  . LYS C 1 357 ? 33.454  25.583  35.913  1.00 68.69  ? 351 LYS C CB  1 
ATOM 8152  C CG  . LYS C 1 357 ? 33.290  26.245  37.278  1.00 71.11  ? 351 LYS C CG  1 
ATOM 8153  C CD  . LYS C 1 357 ? 33.544  25.240  38.401  1.00 80.43  ? 351 LYS C CD  1 
ATOM 8154  C CE  . LYS C 1 357 ? 32.776  25.487  39.671  1.00 90.19  ? 351 LYS C CE  1 
ATOM 8155  N NZ  . LYS C 1 357 ? 33.185  24.574  40.745  1.00 92.03  ? 351 LYS C NZ  1 
ATOM 8156  N N   . THR C 1 358 ? 35.439  25.642  33.484  1.00 67.11  ? 352 THR C N   1 
ATOM 8157  C CA  . THR C 1 358 ? 36.788  25.700  32.915  1.00 64.70  ? 352 THR C CA  1 
ATOM 8158  C C   . THR C 1 358 ? 36.831  26.746  31.801  1.00 62.02  ? 352 THR C C   1 
ATOM 8159  O O   . THR C 1 358 ? 37.791  27.512  31.708  1.00 58.58  ? 352 THR C O   1 
ATOM 8160  C CB  . THR C 1 358 ? 37.241  24.337  32.370  1.00 60.25  ? 352 THR C CB  1 
ATOM 8161  O OG1 . THR C 1 358 ? 37.146  23.349  33.392  1.00 57.15  ? 352 THR C OG1 1 
ATOM 8162  C CG2 . THR C 1 358 ? 38.676  24.341  31.874  1.00 56.46  ? 352 THR C CG2 1 
ATOM 8163  N N   . TYR C 1 359 ? 35.793  26.757  30.951  1.00 55.71  ? 353 TYR C N   1 
ATOM 8164  C CA  . TYR C 1 359 ? 35.718  27.700  29.848  1.00 53.91  ? 353 TYR C CA  1 
ATOM 8165  C C   . TYR C 1 359 ? 35.699  29.137  30.372  1.00 52.80  ? 353 TYR C C   1 
ATOM 8166  O O   . TYR C 1 359 ? 36.537  29.948  29.988  1.00 45.56  ? 353 TYR C O   1 
ATOM 8167  C CB  . TYR C 1 359 ? 34.467  27.335  29.053  1.00 55.16  ? 353 TYR C CB  1 
ATOM 8168  C CG  . TYR C 1 359 ? 34.280  28.139  27.779  1.00 52.31  ? 353 TYR C CG  1 
ATOM 8169  C CD1 . TYR C 1 359 ? 35.352  28.380  26.933  1.00 50.31  ? 353 TYR C CD1 1 
ATOM 8170  C CD2 . TYR C 1 359 ? 33.033  28.647  27.432  1.00 48.04  ? 353 TYR C CD2 1 
ATOM 8171  C CE1 . TYR C 1 359 ? 35.188  29.101  25.767  1.00 52.42  ? 353 TYR C CE1 1 
ATOM 8172  C CE2 . TYR C 1 359 ? 32.860  29.371  26.269  1.00 49.16  ? 353 TYR C CE2 1 
ATOM 8173  C CZ  . TYR C 1 359 ? 33.942  29.602  25.441  1.00 50.81  ? 353 TYR C CZ  1 
ATOM 8174  O OH  . TYR C 1 359 ? 33.808  30.310  24.289  1.00 52.23  ? 353 TYR C OH  1 
ATOM 8175  N N   . GLU C 1 360 ? 34.731  29.426  31.252  1.00 54.28  ? 354 GLU C N   1 
ATOM 8176  C CA  . GLU C 1 360 ? 34.629  30.684  31.976  1.00 58.56  ? 354 GLU C CA  1 
ATOM 8177  C C   . GLU C 1 360 ? 35.983  31.115  32.536  1.00 50.79  ? 354 GLU C C   1 
ATOM 8178  O O   . GLU C 1 360 ? 36.316  32.294  32.497  1.00 45.42  ? 354 GLU C O   1 
ATOM 8179  C CB  . GLU C 1 360 ? 33.618  30.481  33.106  1.00 71.40  ? 354 GLU C CB  1 
ATOM 8180  C CG  . GLU C 1 360 ? 33.526  31.626  34.113  1.00 81.21  ? 354 GLU C CG  1 
ATOM 8181  C CD  . GLU C 1 360 ? 33.065  31.209  35.506  1.00 90.27  ? 354 GLU C CD  1 
ATOM 8182  O OE1 . GLU C 1 360 ? 33.824  30.471  36.198  1.00 93.33  ? 354 GLU C OE1 1 
ATOM 8183  O OE2 . GLU C 1 360 ? 31.946  31.629  35.897  1.00 90.22  ? 354 GLU C OE2 1 
ATOM 8184  N N   . THR C 1 361 ? 36.744  30.166  33.091  1.00 50.61  ? 355 THR C N   1 
ATOM 8185  C CA  . THR C 1 361 ? 38.090  30.444  33.578  1.00 57.61  ? 355 THR C CA  1 
ATOM 8186  C C   . THR C 1 361 ? 38.972  30.982  32.452  1.00 62.37  ? 355 THR C C   1 
ATOM 8187  O O   . THR C 1 361 ? 39.700  31.960  32.648  1.00 60.25  ? 355 THR C O   1 
ATOM 8188  C CB  . THR C 1 361 ? 38.746  29.193  34.166  1.00 54.42  ? 355 THR C CB  1 
ATOM 8189  O OG1 . THR C 1 361 ? 37.982  28.827  35.306  1.00 53.57  ? 355 THR C OG1 1 
ATOM 8190  C CG2 . THR C 1 361 ? 40.191  29.429  34.569  1.00 51.98  ? 355 THR C CG2 1 
ATOM 8191  N N   . THR C 1 362 ? 38.931  30.295  31.299  1.00 60.88  ? 356 THR C N   1 
ATOM 8192  C CA  . THR C 1 362 ? 39.841  30.562  30.192  1.00 61.81  ? 356 THR C CA  1 
ATOM 8193  C C   . THR C 1 362 ? 39.563  31.956  29.601  1.00 61.97  ? 356 THR C C   1 
ATOM 8194  O O   . THR C 1 362 ? 40.470  32.777  29.449  1.00 61.44  ? 356 THR C O   1 
ATOM 8195  C CB  . THR C 1 362 ? 39.714  29.427  29.167  1.00 53.57  ? 356 THR C CB  1 
ATOM 8196  O OG1 . THR C 1 362 ? 39.423  28.255  29.912  1.00 55.43  ? 356 THR C OG1 1 
ATOM 8197  C CG2 . THR C 1 362 ? 40.994  29.133  28.409  1.00 48.29  ? 356 THR C CG2 1 
ATOM 8198  N N   . LEU C 1 363 ? 38.294  32.253  29.311  1.00 57.74  ? 357 LEU C N   1 
ATOM 8199  C CA  . LEU C 1 363 ? 37.921  33.552  28.787  1.00 56.24  ? 357 LEU C CA  1 
ATOM 8200  C C   . LEU C 1 363 ? 38.430  34.690  29.669  1.00 55.63  ? 357 LEU C C   1 
ATOM 8201  O O   . LEU C 1 363 ? 38.581  35.807  29.197  1.00 51.20  ? 357 LEU C O   1 
ATOM 8202  C CB  . LEU C 1 363 ? 36.402  33.603  28.658  1.00 58.66  ? 357 LEU C CB  1 
ATOM 8203  C CG  . LEU C 1 363 ? 35.802  32.680  27.593  1.00 61.34  ? 357 LEU C CG  1 
ATOM 8204  C CD1 . LEU C 1 363 ? 34.405  33.131  27.187  1.00 60.90  ? 357 LEU C CD1 1 
ATOM 8205  C CD2 . LEU C 1 363 ? 36.709  32.584  26.373  1.00 60.88  ? 357 LEU C CD2 1 
ATOM 8206  N N   . GLU C 1 364 ? 38.661  34.438  30.955  1.00 56.79  ? 358 GLU C N   1 
ATOM 8207  C CA  . GLU C 1 364 ? 39.015  35.527  31.844  1.00 64.62  ? 358 GLU C CA  1 
ATOM 8208  C C   . GLU C 1 364 ? 40.526  35.636  31.973  1.00 67.89  ? 358 GLU C C   1 
ATOM 8209  O O   . GLU C 1 364 ? 41.002  36.643  32.486  1.00 80.01  ? 358 GLU C O   1 
ATOM 8210  C CB  . GLU C 1 364 ? 38.380  35.343  33.220  1.00 71.53  ? 358 GLU C CB  1 
ATOM 8211  C CG  . GLU C 1 364 ? 36.860  35.214  33.175  1.00 70.97  ? 358 GLU C CG  1 
ATOM 8212  C CD  . GLU C 1 364 ? 36.071  36.477  33.443  1.00 69.55  ? 358 GLU C CD  1 
ATOM 8213  O OE1 . GLU C 1 364 ? 36.643  37.572  33.685  1.00 72.72  ? 358 GLU C OE1 1 
ATOM 8214  O OE2 . GLU C 1 364 ? 34.834  36.312  33.408  1.00 63.10  ? 358 GLU C OE2 1 
ATOM 8215  N N   . LYS C 1 365 ? 41.234  34.642  31.459  1.00 67.08  ? 359 LYS C N   1 
ATOM 8216  C CA  . LYS C 1 365 ? 42.704  34.745  31.432  1.00 67.14  ? 359 LYS C CA  1 
ATOM 8217  C C   . LYS C 1 365 ? 43.036  35.228  30.037  1.00 67.88  ? 359 LYS C C   1 
ATOM 8218  O O   . LYS C 1 365 ? 43.804  36.181  29.902  1.00 69.42  ? 359 LYS C O   1 
ATOM 8219  C CB  . LYS C 1 365 ? 43.390  33.392  31.593  1.00 67.89  ? 359 LYS C CB  1 
ATOM 8220  C CG  . LYS C 1 365 ? 44.854  33.354  31.193  1.00 77.19  ? 359 LYS C CG  1 
ATOM 8221  C CD  . LYS C 1 365 ? 45.396  31.939  31.041  1.00 87.28  ? 359 LYS C CD  1 
ATOM 8222  C CE  . LYS C 1 365 ? 46.714  31.760  31.725  1.00 93.57  ? 359 LYS C CE  1 
ATOM 8223  N NZ  . LYS C 1 365 ? 47.752  31.292  30.802  1.00 100.32 ? 359 LYS C NZ  1 
ATOM 8224  N N   . CYS C 1 366 ? 42.518  34.517  29.045  1.00 70.83  ? 360 CYS C N   1 
ATOM 8225  C CA  . CYS C 1 366 ? 42.843  34.865  27.646  1.00 78.11  ? 360 CYS C CA  1 
ATOM 8226  C C   . CYS C 1 366 ? 42.346  36.260  27.232  1.00 81.77  ? 360 CYS C C   1 
ATOM 8227  O O   . CYS C 1 366 ? 43.121  36.984  26.603  1.00 90.87  ? 360 CYS C O   1 
ATOM 8228  C CB  . CYS C 1 366 ? 42.247  33.816  26.718  1.00 79.65  ? 360 CYS C CB  1 
ATOM 8229  S SG  . CYS C 1 366 ? 42.694  32.109  27.117  1.00 78.16  ? 360 CYS C SG  1 
ATOM 8230  N N   . CYS C 1 367 ? 41.139  36.654  27.613  1.00 78.21  ? 361 CYS C N   1 
ATOM 8231  C CA  . CYS C 1 367 ? 40.583  37.936  27.099  1.00 77.06  ? 361 CYS C CA  1 
ATOM 8232  C C   . CYS C 1 367 ? 41.417  39.141  27.566  1.00 74.14  ? 361 CYS C C   1 
ATOM 8233  O O   . CYS C 1 367 ? 41.538  40.093  26.784  1.00 81.56  ? 361 CYS C O   1 
ATOM 8234  C CB  . CYS C 1 367 ? 39.071  37.992  27.314  1.00 79.91  ? 361 CYS C CB  1 
ATOM 8235  S SG  . CYS C 1 367 ? 38.152  36.939  26.159  1.00 77.81  ? 361 CYS C SG  1 
ATOM 8236  N N   . ALA C 1 368 ? 41.876  39.150  28.809  1.00 66.09  ? 362 ALA C N   1 
ATOM 8237  C CA  . ALA C 1 368 ? 42.744  40.232  29.335  1.00 63.54  ? 362 ALA C CA  1 
ATOM 8238  C C   . ALA C 1 368 ? 44.063  40.264  28.581  1.00 67.05  ? 362 ALA C C   1 
ATOM 8239  O O   . ALA C 1 368 ? 44.598  41.352  28.360  1.00 67.19  ? 362 ALA C O   1 
ATOM 8240  C CB  . ALA C 1 368 ? 42.974  40.045  30.795  1.00 59.59  ? 362 ALA C CB  1 
ATOM 8241  N N   . ALA C 1 369 ? 44.604  39.104  28.263  1.00 76.53  ? 363 ALA C N   1 
ATOM 8242  C CA  . ALA C 1 369 ? 45.926  38.981  27.607  1.00 83.48  ? 363 ALA C CA  1 
ATOM 8243  C C   . ALA C 1 369 ? 45.964  39.481  26.164  1.00 85.16  ? 363 ALA C C   1 
ATOM 8244  O O   . ALA C 1 369 ? 44.912  39.550  25.522  1.00 82.67  ? 363 ALA C O   1 
ATOM 8245  C CB  . ALA C 1 369 ? 46.353  37.539  27.648  1.00 80.07  ? 363 ALA C CB  1 
ATOM 8246  N N   . ALA C 1 370 ? 47.131  39.934  25.715  1.00 77.54  ? 364 ALA C N   1 
ATOM 8247  C CA  . ALA C 1 370 ? 47.333  40.324  24.304  1.00 75.77  ? 364 ALA C CA  1 
ATOM 8248  C C   . ALA C 1 370 ? 47.241  39.080  23.427  1.00 79.07  ? 364 ALA C C   1 
ATOM 8249  O O   . ALA C 1 370 ? 47.652  38.020  23.917  1.00 88.45  ? 364 ALA C O   1 
ATOM 8250  C CB  . ALA C 1 370 ? 48.694  40.921  24.182  1.00 77.33  ? 364 ALA C CB  1 
ATOM 8251  N N   . ASP C 1 371 ? 46.790  39.188  22.173  1.00 81.25  ? 365 ASP C N   1 
ATOM 8252  C CA  . ASP C 1 371 ? 46.603  37.934  21.382  1.00 86.57  ? 365 ASP C CA  1 
ATOM 8253  C C   . ASP C 1 371 ? 45.688  36.933  22.089  1.00 86.35  ? 365 ASP C C   1 
ATOM 8254  O O   . ASP C 1 371 ? 46.101  35.775  22.261  1.00 80.83  ? 365 ASP C O   1 
ATOM 8255  C CB  . ASP C 1 371 ? 47.911  37.330  20.902  1.00 90.41  ? 365 ASP C CB  1 
ATOM 8256  C CG  . ASP C 1 371 ? 47.947  37.043  19.409  1.00 93.92  ? 365 ASP C CG  1 
ATOM 8257  O OD1 . ASP C 1 371 ? 46.877  37.147  18.774  1.00 91.49  ? 365 ASP C OD1 1 
ATOM 8258  O OD2 . ASP C 1 371 ? 49.039  36.724  18.895  1.00 100.36 ? 365 ASP C OD2 1 
ATOM 8259  N N   . PRO C 1 372 ? 44.497  37.345  22.569  1.00 78.56  ? 366 PRO C N   1 
ATOM 8260  C CA  . PRO C 1 372 ? 43.622  36.491  23.356  1.00 72.94  ? 366 PRO C CA  1 
ATOM 8261  C C   . PRO C 1 372 ? 43.204  35.272  22.557  1.00 66.58  ? 366 PRO C C   1 
ATOM 8262  O O   . PRO C 1 372 ? 43.151  34.182  23.133  1.00 58.36  ? 366 PRO C O   1 
ATOM 8263  C CB  . PRO C 1 372 ? 42.422  37.401  23.638  1.00 67.41  ? 366 PRO C CB  1 
ATOM 8264  C CG  . PRO C 1 372 ? 42.923  38.792  23.414  1.00 70.40  ? 366 PRO C CG  1 
ATOM 8265  C CD  . PRO C 1 372 ? 43.894  38.629  22.275  1.00 73.33  ? 366 PRO C CD  1 
ATOM 8266  N N   . HIS C 1 373 ? 42.949  35.411  21.266  1.00 65.03  ? 367 HIS C N   1 
ATOM 8267  C CA  . HIS C 1 373 ? 42.413  34.288  20.467  1.00 64.27  ? 367 HIS C CA  1 
ATOM 8268  C C   . HIS C 1 373 ? 43.429  33.168  20.512  1.00 60.35  ? 367 HIS C C   1 
ATOM 8269  O O   . HIS C 1 373 ? 43.016  32.006  20.553  1.00 56.38  ? 367 HIS C O   1 
ATOM 8270  C CB  . HIS C 1 373 ? 42.282  34.660  18.997  1.00 70.34  ? 367 HIS C CB  1 
ATOM 8271  C CG  . HIS C 1 373 ? 41.643  33.609  18.156  1.00 80.55  ? 367 HIS C CG  1 
ATOM 8272  N ND1 . HIS C 1 373 ? 42.261  32.422  17.833  1.00 85.22  ? 367 HIS C ND1 1 
ATOM 8273  C CD2 . HIS C 1 373 ? 40.445  33.573  17.568  1.00 86.77  ? 367 HIS C CD2 1 
ATOM 8274  C CE1 . HIS C 1 373 ? 41.450  31.698  17.078  1.00 87.00  ? 367 HIS C CE1 1 
ATOM 8275  N NE2 . HIS C 1 373 ? 40.341  32.379  16.905  1.00 90.46  ? 367 HIS C NE2 1 
ATOM 8276  N N   . GLU C 1 374 ? 44.706  33.490  20.451  1.00 62.08  ? 368 GLU C N   1 
ATOM 8277  C CA  . GLU C 1 374 ? 45.641  32.356  20.451  1.00 67.67  ? 368 GLU C CA  1 
ATOM 8278  C C   . GLU C 1 374 ? 45.503  31.573  21.750  1.00 69.85  ? 368 GLU C C   1 
ATOM 8279  O O   . GLU C 1 374 ? 45.548  30.336  21.695  1.00 67.87  ? 368 GLU C O   1 
ATOM 8280  C CB  . GLU C 1 374 ? 47.060  32.883  20.558  1.00 73.29  ? 368 GLU C CB  1 
ATOM 8281  C CG  . GLU C 1 374 ? 48.120  31.794  20.445  1.00 73.44  ? 368 GLU C CG  1 
ATOM 8282  C CD  . GLU C 1 374 ? 49.019  31.713  21.660  1.00 71.13  ? 368 GLU C CD  1 
ATOM 8283  O OE1 . GLU C 1 374 ? 48.517  31.357  22.742  1.00 65.83  ? 368 GLU C OE1 1 
ATOM 8284  O OE2 . GLU C 1 374 ? 50.219  32.010  21.518  1.00 76.07  ? 368 GLU C OE2 1 
ATOM 8285  N N   . CYS C 1 375 ? 45.364  32.260  22.881  1.00 82.45  ? 369 CYS C N   1 
ATOM 8286  C CA  . CYS C 1 375 ? 45.151  31.535  24.156  1.00 80.85  ? 369 CYS C CA  1 
ATOM 8287  C C   . CYS C 1 375 ? 43.844  30.723  24.226  1.00 69.32  ? 369 CYS C C   1 
ATOM 8288  O O   . CYS C 1 375 ? 43.920  29.553  24.619  1.00 64.01  ? 369 CYS C O   1 
ATOM 8289  C CB  . CYS C 1 375 ? 45.089  32.581  25.264  1.00 80.18  ? 369 CYS C CB  1 
ATOM 8290  S SG  . CYS C 1 375 ? 44.715  31.968  26.925  1.00 82.10  ? 369 CYS C SG  1 
ATOM 8291  N N   . TYR C 1 376 ? 42.717  31.271  23.777  1.00 60.91  ? 370 TYR C N   1 
ATOM 8292  C CA  . TYR C 1 376 ? 41.465  30.473  23.791  1.00 55.06  ? 370 TYR C CA  1 
ATOM 8293  C C   . TYR C 1 376 ? 41.576  29.306  22.869  1.00 53.66  ? 370 TYR C C   1 
ATOM 8294  O O   . TYR C 1 376 ? 41.106  28.227  23.188  1.00 54.38  ? 370 TYR C O   1 
ATOM 8295  C CB  . TYR C 1 376 ? 40.101  31.122  23.521  1.00 57.36  ? 370 TYR C CB  1 
ATOM 8296  C CG  . TYR C 1 376 ? 39.804  32.325  22.641  1.00 53.20  ? 370 TYR C CG  1 
ATOM 8297  C CD1 . TYR C 1 376 ? 39.945  33.618  23.119  1.00 53.19  ? 370 TYR C CD1 1 
ATOM 8298  C CD2 . TYR C 1 376 ? 39.232  32.156  21.390  1.00 53.59  ? 370 TYR C CD2 1 
ATOM 8299  C CE1 . TYR C 1 376 ? 39.612  34.711  22.340  1.00 50.09  ? 370 TYR C CE1 1 
ATOM 8300  C CE2 . TYR C 1 376 ? 38.898  33.240  20.599  1.00 56.93  ? 370 TYR C CE2 1 
ATOM 8301  C CZ  . TYR C 1 376 ? 39.086  34.521  21.077  1.00 52.77  ? 370 TYR C CZ  1 
ATOM 8302  O OH  . TYR C 1 376 ? 38.759  35.587  20.297  1.00 50.79  ? 370 TYR C OH  1 
ATOM 8303  N N   . ALA C 1 377 ? 42.173  29.529  21.717  1.00 63.73  ? 371 ALA C N   1 
ATOM 8304  C CA  . ALA C 1 377 ? 42.170  28.491  20.668  1.00 70.50  ? 371 ALA C CA  1 
ATOM 8305  C C   . ALA C 1 377 ? 42.476  27.104  21.206  1.00 74.57  ? 371 ALA C C   1 
ATOM 8306  O O   . ALA C 1 377 ? 41.854  26.133  20.749  1.00 68.50  ? 371 ALA C O   1 
ATOM 8307  C CB  . ALA C 1 377 ? 43.175  28.867  19.631  1.00 73.88  ? 371 ALA C CB  1 
ATOM 8308  N N   . LYS C 1 378 ? 43.424  27.002  22.124  1.00 86.01  ? 372 LYS C N   1 
ATOM 8309  C CA  . LYS C 1 378 ? 43.803  25.655  22.535  1.00 94.79  ? 372 LYS C CA  1 
ATOM 8310  C C   . LYS C 1 378 ? 42.978  25.198  23.746  1.00 89.28  ? 372 LYS C C   1 
ATOM 8311  O O   . LYS C 1 378 ? 43.482  24.497  24.619  1.00 83.25  ? 372 LYS C O   1 
ATOM 8312  C CB  . LYS C 1 378 ? 45.321  25.648  22.775  1.00 106.42 ? 372 LYS C CB  1 
ATOM 8313  C CG  . LYS C 1 378 ? 45.920  24.321  23.274  1.00 120.18 ? 372 LYS C CG  1 
ATOM 8314  C CD  . LYS C 1 378 ? 47.442  24.178  23.192  1.00 117.82 ? 372 LYS C CD  1 
ATOM 8315  C CE  . LYS C 1 378 ? 47.993  22.914  23.808  1.00 104.33 ? 372 LYS C CE  1 
ATOM 8316  N NZ  . LYS C 1 378 ? 47.678  22.784  25.235  1.00 97.98  ? 372 LYS C NZ  1 
ATOM 8317  N N   . VAL C 1 379 ? 41.687  25.559  23.787  1.00 83.36  ? 373 VAL C N   1 
ATOM 8318  C CA  . VAL C 1 379 ? 40.887  25.402  24.995  1.00 71.35  ? 373 VAL C CA  1 
ATOM 8319  C C   . VAL C 1 379 ? 40.352  23.979  25.054  1.00 70.30  ? 373 VAL C C   1 
ATOM 8320  O O   . VAL C 1 379 ? 40.084  23.475  26.145  1.00 76.36  ? 373 VAL C O   1 
ATOM 8321  C CB  . VAL C 1 379 ? 39.726  26.406  25.161  1.00 65.36  ? 373 VAL C CB  1 
ATOM 8322  C CG1 . VAL C 1 379 ? 38.681  26.298  24.059  1.00 66.72  ? 373 VAL C CG1 1 
ATOM 8323  C CG2 . VAL C 1 379 ? 39.048  26.261  26.515  1.00 63.94  ? 373 VAL C CG2 1 
ATOM 8324  N N   . PHE C 1 380 ? 40.178  23.345  23.889  1.00 68.69  ? 374 PHE C N   1 
ATOM 8325  C CA  . PHE C 1 380 ? 39.603  22.010  23.858  1.00 71.28  ? 374 PHE C CA  1 
ATOM 8326  C C   . PHE C 1 380 ? 40.607  21.008  24.413  1.00 68.80  ? 374 PHE C C   1 
ATOM 8327  O O   . PHE C 1 380 ? 40.214  19.925  24.831  1.00 81.76  ? 374 PHE C O   1 
ATOM 8328  C CB  . PHE C 1 380 ? 39.137  21.550  22.477  1.00 71.03  ? 374 PHE C CB  1 
ATOM 8329  C CG  . PHE C 1 380 ? 37.665  21.810  22.188  1.00 75.41  ? 374 PHE C CG  1 
ATOM 8330  C CD1 . PHE C 1 380 ? 37.131  23.093  22.246  1.00 77.42  ? 374 PHE C CD1 1 
ATOM 8331  C CD2 . PHE C 1 380 ? 36.816  20.754  21.875  1.00 81.85  ? 374 PHE C CD2 1 
ATOM 8332  C CE1 . PHE C 1 380 ? 35.791  23.311  21.970  1.00 82.31  ? 374 PHE C CE1 1 
ATOM 8333  C CE2 . PHE C 1 380 ? 35.478  20.976  21.598  1.00 86.84  ? 374 PHE C CE2 1 
ATOM 8334  C CZ  . PHE C 1 380 ? 34.970  22.253  21.647  1.00 90.96  ? 374 PHE C CZ  1 
ATOM 8335  N N   . ASP C 1 381 ? 41.885  21.394  24.437  1.00 67.74  ? 375 ASP C N   1 
ATOM 8336  C CA  . ASP C 1 381 ? 42.943  20.594  25.035  1.00 73.32  ? 375 ASP C CA  1 
ATOM 8337  C C   . ASP C 1 381 ? 42.883  20.607  26.569  1.00 74.59  ? 375 ASP C C   1 
ATOM 8338  O O   . ASP C 1 381 ? 43.661  19.909  27.223  1.00 74.56  ? 375 ASP C O   1 
ATOM 8339  C CB  . ASP C 1 381 ? 44.301  21.051  24.523  1.00 78.65  ? 375 ASP C CB  1 
ATOM 8340  C CG  . ASP C 1 381 ? 44.672  20.576  23.125  1.00 84.21  ? 375 ASP C CG  1 
ATOM 8341  O OD1 . ASP C 1 381 ? 43.934  19.724  22.568  1.00 92.32  ? 375 ASP C OD1 1 
ATOM 8342  O OD2 . ASP C 1 381 ? 45.704  21.051  22.610  1.00 80.39  ? 375 ASP C OD2 1 
ATOM 8343  N N   . GLU C 1 382 ? 41.979  21.408  27.149  1.00 71.97  ? 376 GLU C N   1 
ATOM 8344  C CA  . GLU C 1 382 ? 41.742  21.396  28.584  1.00 70.31  ? 376 GLU C CA  1 
ATOM 8345  C C   . GLU C 1 382 ? 40.473  20.601  28.907  1.00 70.73  ? 376 GLU C C   1 
ATOM 8346  O O   . GLU C 1 382 ? 40.396  19.942  29.947  1.00 66.65  ? 376 GLU C O   1 
ATOM 8347  C CB  . GLU C 1 382 ? 41.672  22.828  29.109  1.00 73.69  ? 376 GLU C CB  1 
ATOM 8348  C CG  . GLU C 1 382 ? 42.961  23.616  28.892  1.00 83.22  ? 376 GLU C CG  1 
ATOM 8349  C CD  . GLU C 1 382 ? 42.844  25.102  29.209  1.00 99.14  ? 376 GLU C CD  1 
ATOM 8350  O OE1 . GLU C 1 382 ? 42.557  25.428  30.388  1.00 102.84 ? 376 GLU C OE1 1 
ATOM 8351  O OE2 . GLU C 1 382 ? 43.031  25.936  28.284  1.00 103.81 ? 376 GLU C OE2 1 
ATOM 8352  N N   . PHE C 1 383 ? 39.481  20.648  28.006  1.00 66.40  ? 377 PHE C N   1 
ATOM 8353  C CA  . PHE C 1 383 ? 38.271  19.859  28.174  1.00 64.40  ? 377 PHE C CA  1 
ATOM 8354  C C   . PHE C 1 383 ? 38.598  18.366  28.172  1.00 71.44  ? 377 PHE C C   1 
ATOM 8355  O O   . PHE C 1 383 ? 37.931  17.604  28.868  1.00 72.41  ? 377 PHE C O   1 
ATOM 8356  C CB  . PHE C 1 383 ? 37.234  20.092  27.075  1.00 58.52  ? 377 PHE C CB  1 
ATOM 8357  C CG  . PHE C 1 383 ? 36.721  21.515  26.936  1.00 57.01  ? 377 PHE C CG  1 
ATOM 8358  C CD1 . PHE C 1 383 ? 37.107  22.516  27.812  1.00 59.27  ? 377 PHE C CD1 1 
ATOM 8359  C CD2 . PHE C 1 383 ? 35.810  21.838  25.937  1.00 62.06  ? 377 PHE C CD2 1 
ATOM 8360  C CE1 . PHE C 1 383 ? 36.613  23.803  27.664  1.00 66.24  ? 377 PHE C CE1 1 
ATOM 8361  C CE2 . PHE C 1 383 ? 35.310  23.126  25.799  1.00 60.00  ? 377 PHE C CE2 1 
ATOM 8362  C CZ  . PHE C 1 383 ? 35.717  24.107  26.657  1.00 62.77  ? 377 PHE C CZ  1 
ATOM 8363  N N   . LYS C 1 384 ? 39.608  17.960  27.381  1.00 71.75  ? 378 LYS C N   1 
ATOM 8364  C CA  . LYS C 1 384 ? 39.869  16.556  27.100  1.00 65.55  ? 378 LYS C CA  1 
ATOM 8365  C C   . LYS C 1 384 ? 40.155  15.796  28.401  1.00 60.36  ? 378 LYS C C   1 
ATOM 8366  O O   . LYS C 1 384 ? 39.467  14.824  28.709  1.00 53.51  ? 378 LYS C O   1 
ATOM 8367  C CB  . LYS C 1 384 ? 40.929  16.431  25.999  1.00 65.48  ? 378 LYS C CB  1 
ATOM 8368  C CG  . LYS C 1 384 ? 41.013  15.031  25.421  1.00 81.36  ? 378 LYS C CG  1 
ATOM 8369  C CD  . LYS C 1 384 ? 41.834  14.848  24.147  1.00 92.65  ? 378 LYS C CD  1 
ATOM 8370  C CE  . LYS C 1 384 ? 41.766  13.424  23.647  1.00 93.72  ? 378 LYS C CE  1 
ATOM 8371  N NZ  . LYS C 1 384 ? 42.681  13.143  22.538  1.00 95.83  ? 378 LYS C NZ  1 
ATOM 8372  N N   . PRO C 1 385 ? 41.132  16.219  29.235  1.00 61.41  ? 379 PRO C N   1 
ATOM 8373  C CA  . PRO C 1 385 ? 41.404  15.541  30.507  1.00 62.04  ? 379 PRO C CA  1 
ATOM 8374  C C   . PRO C 1 385 ? 40.222  15.374  31.455  1.00 61.27  ? 379 PRO C C   1 
ATOM 8375  O O   . PRO C 1 385 ? 40.196  14.412  32.210  1.00 63.04  ? 379 PRO C O   1 
ATOM 8376  C CB  . PRO C 1 385 ? 42.483  16.414  31.144  1.00 67.74  ? 379 PRO C CB  1 
ATOM 8377  C CG  . PRO C 1 385 ? 43.179  17.056  29.964  1.00 70.16  ? 379 PRO C CG  1 
ATOM 8378  C CD  . PRO C 1 385 ? 42.055  17.333  28.982  1.00 68.49  ? 379 PRO C CD  1 
ATOM 8379  N N   . LEU C 1 386 ? 39.272  16.322  31.421  1.00 67.19  ? 380 LEU C N   1 
ATOM 8380  C CA  . LEU C 1 386 ? 38.100  16.331  32.295  1.00 63.04  ? 380 LEU C CA  1 
ATOM 8381  C C   . LEU C 1 386 ? 37.014  15.380  31.796  1.00 57.91  ? 380 LEU C C   1 
ATOM 8382  O O   . LEU C 1 386 ? 36.211  14.914  32.602  1.00 53.24  ? 380 LEU C O   1 
ATOM 8383  C CB  . LEU C 1 386 ? 37.510  17.738  32.398  1.00 65.81  ? 380 LEU C CB  1 
ATOM 8384  C CG  . LEU C 1 386 ? 38.277  18.756  33.245  1.00 70.63  ? 380 LEU C CG  1 
ATOM 8385  C CD1 . LEU C 1 386 ? 37.559  20.086  33.101  1.00 78.27  ? 380 LEU C CD1 1 
ATOM 8386  C CD2 . LEU C 1 386 ? 38.378  18.344  34.706  1.00 70.70  ? 380 LEU C CD2 1 
ATOM 8387  N N   . VAL C 1 387 ? 36.958  15.161  30.472  1.00 58.60  ? 381 VAL C N   1 
ATOM 8388  C CA  . VAL C 1 387 ? 36.008  14.239  29.864  1.00 62.10  ? 381 VAL C CA  1 
ATOM 8389  C C   . VAL C 1 387 ? 36.456  12.788  30.075  1.00 66.21  ? 381 VAL C C   1 
ATOM 8390  O O   . VAL C 1 387 ? 35.612  11.898  30.210  1.00 60.30  ? 381 VAL C O   1 
ATOM 8391  C CB  . VAL C 1 387 ? 35.818  14.518  28.362  1.00 58.19  ? 381 VAL C CB  1 
ATOM 8392  C CG1 . VAL C 1 387 ? 34.754  13.604  27.775  1.00 60.09  ? 381 VAL C CG1 1 
ATOM 8393  C CG2 . VAL C 1 387 ? 35.448  15.964  28.087  1.00 58.10  ? 381 VAL C CG2 1 
ATOM 8394  N N   . GLU C 1 388 ? 37.779  12.556  30.100  1.00 66.24  ? 382 GLU C N   1 
ATOM 8395  C CA  . GLU C 1 388 ? 38.332  11.213  30.044  1.00 72.07  ? 382 GLU C CA  1 
ATOM 8396  C C   . GLU C 1 388 ? 38.580  10.633  31.439  1.00 78.67  ? 382 GLU C C   1 
ATOM 8397  O O   . GLU C 1 388 ? 38.616  9.411   31.599  1.00 90.55  ? 382 GLU C O   1 
ATOM 8398  C CB  . GLU C 1 388 ? 39.585  11.230  29.172  1.00 76.51  ? 382 GLU C CB  1 
ATOM 8399  C CG  . GLU C 1 388 ? 39.253  11.432  27.695  1.00 87.23  ? 382 GLU C CG  1 
ATOM 8400  C CD  . GLU C 1 388 ? 40.423  11.265  26.739  1.00 90.73  ? 382 GLU C CD  1 
ATOM 8401  O OE1 . GLU C 1 388 ? 41.531  10.998  27.261  1.00 93.34  ? 382 GLU C OE1 1 
ATOM 8402  O OE2 . GLU C 1 388 ? 40.233  11.397  25.498  1.00 80.88  ? 382 GLU C OE2 1 
ATOM 8403  N N   . GLU C 1 389 ? 38.749  11.494  32.449  1.00 73.04  ? 383 GLU C N   1 
ATOM 8404  C CA  . GLU C 1 389 ? 38.853  11.030  33.826  1.00 66.80  ? 383 GLU C CA  1 
ATOM 8405  C C   . GLU C 1 389 ? 37.670  10.105  34.127  1.00 62.30  ? 383 GLU C C   1 
ATOM 8406  O O   . GLU C 1 389 ? 37.885  8.918   34.377  1.00 51.68  ? 383 GLU C O   1 
ATOM 8407  C CB  . GLU C 1 389 ? 39.038  12.225  34.772  1.00 69.59  ? 383 GLU C CB  1 
ATOM 8408  C CG  . GLU C 1 389 ? 39.187  11.861  36.250  1.00 75.68  ? 383 GLU C CG  1 
ATOM 8409  C CD  . GLU C 1 389 ? 37.932  11.875  37.120  1.00 78.86  ? 383 GLU C CD  1 
ATOM 8410  O OE1 . GLU C 1 389 ? 36.920  12.457  36.674  1.00 86.55  ? 383 GLU C OE1 1 
ATOM 8411  O OE2 . GLU C 1 389 ? 37.947  11.301  38.241  1.00 73.27  ? 383 GLU C OE2 1 
ATOM 8412  N N   . PRO C 1 390 ? 36.400  10.591  34.055  1.00 62.18  ? 384 PRO C N   1 
ATOM 8413  C CA  . PRO C 1 390 ? 35.218  9.774   34.337  1.00 58.04  ? 384 PRO C CA  1 
ATOM 8414  C C   . PRO C 1 390 ? 35.048  8.580   33.403  1.00 61.72  ? 384 PRO C C   1 
ATOM 8415  O O   . PRO C 1 390 ? 34.697  7.490   33.849  1.00 63.92  ? 384 PRO C O   1 
ATOM 8416  C CB  . PRO C 1 390 ? 34.038  10.747  34.168  1.00 57.00  ? 384 PRO C CB  1 
ATOM 8417  C CG  . PRO C 1 390 ? 34.646  12.111  34.279  1.00 61.16  ? 384 PRO C CG  1 
ATOM 8418  C CD  . PRO C 1 390 ? 36.018  11.957  33.664  1.00 64.31  ? 384 PRO C CD  1 
ATOM 8419  N N   . GLN C 1 391 ? 35.265  8.795   32.100  1.00 61.62  ? 385 GLN C N   1 
ATOM 8420  C CA  . GLN C 1 391 ? 35.063  7.736   31.124  1.00 64.37  ? 385 GLN C CA  1 
ATOM 8421  C C   . GLN C 1 391 ? 35.958  6.535   31.418  1.00 66.43  ? 385 GLN C C   1 
ATOM 8422  O O   . GLN C 1 391 ? 35.473  5.407   31.422  1.00 70.07  ? 385 GLN C O   1 
ATOM 8423  C CB  . GLN C 1 391 ? 35.295  8.209   29.693  1.00 66.07  ? 385 GLN C CB  1 
ATOM 8424  C CG  . GLN C 1 391 ? 34.004  8.554   28.964  1.00 69.21  ? 385 GLN C CG  1 
ATOM 8425  C CD  . GLN C 1 391 ? 34.217  9.466   27.777  1.00 77.58  ? 385 GLN C CD  1 
ATOM 8426  O OE1 . GLN C 1 391 ? 35.327  9.958   27.530  1.00 77.85  ? 385 GLN C OE1 1 
ATOM 8427  N NE2 . GLN C 1 391 ? 33.134  9.732   27.055  1.00 79.35  ? 385 GLN C NE2 1 
ATOM 8428  N N   . ASN C 1 392 ? 37.257  6.784   31.635  1.00 65.11  ? 386 ASN C N   1 
ATOM 8429  C CA  . ASN C 1 392 ? 38.212  5.734   31.955  1.00 63.36  ? 386 ASN C CA  1 
ATOM 8430  C C   . ASN C 1 392 ? 37.898  5.113   33.312  1.00 61.12  ? 386 ASN C C   1 
ATOM 8431  O O   . ASN C 1 392 ? 38.125  3.927   33.515  1.00 59.23  ? 386 ASN C O   1 
ATOM 8432  C CB  . ASN C 1 392 ? 39.641  6.255   31.937  1.00 64.42  ? 386 ASN C CB  1 
ATOM 8433  C CG  . ASN C 1 392 ? 40.094  6.601   30.539  1.00 72.29  ? 386 ASN C CG  1 
ATOM 8434  O OD1 . ASN C 1 392 ? 39.348  6.431   29.564  1.00 75.24  ? 386 ASN C OD1 1 
ATOM 8435  N ND2 . ASN C 1 392 ? 41.327  7.069   30.425  1.00 76.39  ? 386 ASN C ND2 1 
ATOM 8436  N N   . LEU C 1 393 ? 37.366  5.921   34.231  1.00 63.46  ? 387 LEU C N   1 
ATOM 8437  C CA  . LEU C 1 393 ? 36.953  5.432   35.533  1.00 64.77  ? 387 LEU C CA  1 
ATOM 8438  C C   . LEU C 1 393 ? 35.790  4.456   35.389  1.00 61.22  ? 387 LEU C C   1 
ATOM 8439  O O   . LEU C 1 393 ? 35.763  3.441   36.081  1.00 60.70  ? 387 LEU C O   1 
ATOM 8440  C CB  . LEU C 1 393 ? 36.551  6.580   36.449  1.00 70.51  ? 387 LEU C CB  1 
ATOM 8441  C CG  . LEU C 1 393 ? 36.613  6.249   37.939  1.00 79.82  ? 387 LEU C CG  1 
ATOM 8442  C CD1 . LEU C 1 393 ? 38.076  6.355   38.360  1.00 86.60  ? 387 LEU C CD1 1 
ATOM 8443  C CD2 . LEU C 1 393 ? 35.700  7.150   38.769  1.00 84.81  ? 387 LEU C CD2 1 
ATOM 8444  N N   . ILE C 1 394 ? 34.816  4.790   34.530  1.00 56.09  ? 388 ILE C N   1 
ATOM 8445  C CA  . ILE C 1 394 ? 33.628  3.966   34.364  1.00 54.09  ? 388 ILE C CA  1 
ATOM 8446  C C   . ILE C 1 394 ? 34.001  2.611   33.763  1.00 63.14  ? 388 ILE C C   1 
ATOM 8447  O O   . ILE C 1 394 ? 33.382  1.590   34.088  1.00 57.17  ? 388 ILE C O   1 
ATOM 8448  C CB  . ILE C 1 394 ? 32.577  4.680   33.504  1.00 50.36  ? 388 ILE C CB  1 
ATOM 8449  C CG1 . ILE C 1 394 ? 31.823  5.721   34.316  1.00 53.92  ? 388 ILE C CG1 1 
ATOM 8450  C CG2 . ILE C 1 394 ? 31.629  3.658   32.877  1.00 51.00  ? 388 ILE C CG2 1 
ATOM 8451  C CD1 . ILE C 1 394 ? 30.790  6.515   33.531  1.00 56.14  ? 388 ILE C CD1 1 
ATOM 8452  N N   . LYS C 1 395 ? 34.999  2.621   32.867  1.00 68.96  ? 389 LYS C N   1 
ATOM 8453  C CA  . LYS C 1 395 ? 35.420  1.418   32.168  1.00 73.49  ? 389 LYS C CA  1 
ATOM 8454  C C   . LYS C 1 395 ? 36.123  0.483   33.160  1.00 78.34  ? 389 LYS C C   1 
ATOM 8455  O O   . LYS C 1 395 ? 35.632  -0.622  33.408  1.00 80.09  ? 389 LYS C O   1 
ATOM 8456  C CB  . LYS C 1 395 ? 36.237  1.786   30.921  1.00 77.45  ? 389 LYS C CB  1 
ATOM 8457  C CG  . LYS C 1 395 ? 35.466  2.520   29.818  1.00 83.41  ? 389 LYS C CG  1 
ATOM 8458  C CD  . LYS C 1 395 ? 36.330  2.993   28.648  1.00 95.25  ? 389 LYS C CD  1 
ATOM 8459  C CE  . LYS C 1 395 ? 35.635  3.904   27.661  1.00 97.24  ? 389 LYS C CE  1 
ATOM 8460  N NZ  . LYS C 1 395 ? 36.488  4.367   26.557  1.00 90.67  ? 389 LYS C NZ  1 
ATOM 8461  N N   . GLN C 1 396 ? 37.237  0.936   33.763  1.00 72.91  ? 390 GLN C N   1 
ATOM 8462  C CA  . GLN C 1 396 ? 37.993  0.120   34.710  1.00 68.90  ? 390 GLN C CA  1 
ATOM 8463  C C   . GLN C 1 396 ? 37.059  -0.574  35.698  1.00 65.69  ? 390 GLN C C   1 
ATOM 8464  O O   . GLN C 1 396 ? 37.360  -1.677  36.133  1.00 73.65  ? 390 GLN C O   1 
ATOM 8465  C CB  . GLN C 1 396 ? 39.000  0.899   35.556  1.00 71.87  ? 390 GLN C CB  1 
ATOM 8466  C CG  . GLN C 1 396 ? 40.141  1.510   34.750  1.00 83.89  ? 390 GLN C CG  1 
ATOM 8467  C CD  . GLN C 1 396 ? 40.740  2.745   35.392  1.00 102.21 ? 390 GLN C CD  1 
ATOM 8468  O OE1 . GLN C 1 396 ? 40.571  2.997   36.593  1.00 115.16 ? 390 GLN C OE1 1 
ATOM 8469  N NE2 . GLN C 1 396 ? 41.449  3.533   34.591  1.00 104.59 ? 390 GLN C NE2 1 
ATOM 8470  N N   . ASN C 1 397 ? 35.944  0.082   36.054  1.00 65.16  ? 391 ASN C N   1 
ATOM 8471  C CA  . ASN C 1 397 ? 34.989  -0.440  37.025  1.00 64.54  ? 391 ASN C CA  1 
ATOM 8472  C C   . ASN C 1 397 ? 33.924  -1.319  36.360  1.00 60.63  ? 391 ASN C C   1 
ATOM 8473  O O   . ASN C 1 397 ? 33.472  -2.308  36.938  1.00 60.18  ? 391 ASN C O   1 
ATOM 8474  C CB  . ASN C 1 397 ? 34.328  0.679   37.830  1.00 59.60  ? 391 ASN C CB  1 
ATOM 8475  C CG  . ASN C 1 397 ? 35.199  1.179   38.959  1.00 57.03  ? 391 ASN C CG  1 
ATOM 8476  O OD1 . ASN C 1 397 ? 35.414  0.468   39.945  1.00 53.60  ? 391 ASN C OD1 1 
ATOM 8477  N ND2 . ASN C 1 397 ? 35.698  2.401   38.849  1.00 59.84  ? 391 ASN C ND2 1 
ATOM 8478  N N   . CYS C 1 398 ? 33.478  -0.967  35.157  1.00 56.00  ? 392 CYS C N   1 
ATOM 8479  C CA  . CYS C 1 398 ? 32.561  -1.864  34.481  1.00 58.33  ? 392 CYS C CA  1 
ATOM 8480  C C   . CYS C 1 398 ? 33.268  -3.134  34.032  1.00 55.12  ? 392 CYS C C   1 
ATOM 8481  O O   . CYS C 1 398 ? 32.624  -4.165  33.963  1.00 47.73  ? 392 CYS C O   1 
ATOM 8482  C CB  . CYS C 1 398 ? 31.878  -1.206  33.300  1.00 65.96  ? 392 CYS C CB  1 
ATOM 8483  S SG  . CYS C 1 398 ? 30.375  -0.352  33.821  1.00 73.25  ? 392 CYS C SG  1 
ATOM 8484  N N   . GLU C 1 399 ? 34.567  -3.041  33.713  1.00 60.59  ? 393 GLU C N   1 
ATOM 8485  C CA  . GLU C 1 399 ? 35.377  -4.212  33.405  1.00 67.87  ? 393 GLU C CA  1 
ATOM 8486  C C   . GLU C 1 399 ? 35.451  -5.131  34.627  1.00 65.21  ? 393 GLU C C   1 
ATOM 8487  O O   . GLU C 1 399 ? 35.221  -6.342  34.530  1.00 72.10  ? 393 GLU C O   1 
ATOM 8488  C CB  . GLU C 1 399 ? 36.810  -3.851  33.001  1.00 72.30  ? 393 GLU C CB  1 
ATOM 8489  C CG  . GLU C 1 399 ? 37.013  -3.543  31.519  1.00 77.27  ? 393 GLU C CG  1 
ATOM 8490  C CD  . GLU C 1 399 ? 38.476  -3.613  31.071  1.00 86.99  ? 393 GLU C CD  1 
ATOM 8491  O OE1 . GLU C 1 399 ? 39.333  -3.964  31.924  1.00 78.94  ? 393 GLU C OE1 1 
ATOM 8492  O OE2 . GLU C 1 399 ? 38.777  -3.328  29.878  1.00 90.70  ? 393 GLU C OE2 1 
ATOM 8493  N N   . LEU C 1 400 ? 35.790  -4.537  35.774  1.00 57.72  ? 394 LEU C N   1 
ATOM 8494  C CA  . LEU C 1 400 ? 35.988  -5.279  37.001  1.00 55.40  ? 394 LEU C CA  1 
ATOM 8495  C C   . LEU C 1 400 ? 34.672  -5.916  37.447  1.00 54.59  ? 394 LEU C C   1 
ATOM 8496  O O   . LEU C 1 400 ? 34.689  -7.035  37.941  1.00 54.99  ? 394 LEU C O   1 
ATOM 8497  C CB  . LEU C 1 400 ? 36.575  -4.344  38.053  1.00 63.37  ? 394 LEU C CB  1 
ATOM 8498  C CG  . LEU C 1 400 ? 37.412  -5.016  39.145  1.00 77.52  ? 394 LEU C CG  1 
ATOM 8499  C CD1 . LEU C 1 400 ? 38.627  -5.744  38.566  1.00 78.09  ? 394 LEU C CD1 1 
ATOM 8500  C CD2 . LEU C 1 400 ? 37.841  -3.991  40.196  1.00 79.68  ? 394 LEU C CD2 1 
ATOM 8501  N N   . PHE C 1 401 ? 33.534  -5.234  37.242  1.00 56.61  ? 395 PHE C N   1 
ATOM 8502  C CA  . PHE C 1 401 ? 32.221  -5.776  37.583  1.00 53.99  ? 395 PHE C CA  1 
ATOM 8503  C C   . PHE C 1 401 ? 31.799  -6.889  36.626  1.00 56.67  ? 395 PHE C C   1 
ATOM 8504  O O   . PHE C 1 401 ? 30.906  -7.670  36.958  1.00 58.61  ? 395 PHE C O   1 
ATOM 8505  C CB  . PHE C 1 401 ? 31.123  -4.716  37.509  1.00 50.46  ? 395 PHE C CB  1 
ATOM 8506  C CG  . PHE C 1 401 ? 29.694  -5.253  37.521  1.00 50.50  ? 395 PHE C CG  1 
ATOM 8507  C CD1 . PHE C 1 401 ? 29.062  -5.679  36.354  1.00 48.17  ? 395 PHE C CD1 1 
ATOM 8508  C CD2 . PHE C 1 401 ? 28.954  -5.283  38.699  1.00 55.23  ? 395 PHE C CD2 1 
ATOM 8509  C CE1 . PHE C 1 401 ? 27.743  -6.124  36.366  1.00 46.01  ? 395 PHE C CE1 1 
ATOM 8510  C CE2 . PHE C 1 401 ? 27.633  -5.726  38.704  1.00 51.93  ? 395 PHE C CE2 1 
ATOM 8511  C CZ  . PHE C 1 401 ? 27.031  -6.145  37.535  1.00 46.10  ? 395 PHE C CZ  1 
ATOM 8512  N N   . GLU C 1 402 ? 32.385  -6.899  35.417  1.00 63.89  ? 396 GLU C N   1 
ATOM 8513  C CA  . GLU C 1 402 ? 32.001  -7.824  34.359  1.00 69.34  ? 396 GLU C CA  1 
ATOM 8514  C C   . GLU C 1 402 ? 32.770  -9.130  34.502  1.00 62.96  ? 396 GLU C C   1 
ATOM 8515  O O   . GLU C 1 402 ? 32.331  -10.138 33.954  1.00 63.06  ? 396 GLU C O   1 
ATOM 8516  C CB  . GLU C 1 402 ? 32.176  -7.237  32.954  1.00 83.52  ? 396 GLU C CB  1 
ATOM 8517  C CG  . GLU C 1 402 ? 31.994  -8.210  31.783  1.00 97.58  ? 396 GLU C CG  1 
ATOM 8518  C CD  . GLU C 1 402 ? 30.660  -8.931  31.574  1.00 107.19 ? 396 GLU C CD  1 
ATOM 8519  O OE1 . GLU C 1 402 ? 29.741  -8.785  32.409  1.00 118.45 ? 396 GLU C OE1 1 
ATOM 8520  O OE2 . GLU C 1 402 ? 30.527  -9.649  30.550  1.00 101.65 ? 396 GLU C OE2 1 
ATOM 8521  N N   . GLN C 1 403 ? 33.893  -9.123  35.232  1.00 61.07  ? 397 GLN C N   1 
ATOM 8522  C CA  . GLN C 1 403 ? 34.529  -10.384 35.597  1.00 74.48  ? 397 GLN C CA  1 
ATOM 8523  C C   . GLN C 1 403 ? 33.960  -10.918 36.926  1.00 75.92  ? 397 GLN C C   1 
ATOM 8524  O O   . GLN C 1 403 ? 33.519  -12.070 36.998  1.00 93.37  ? 397 GLN C O   1 
ATOM 8525  C CB  . GLN C 1 403 ? 36.058  -10.354 35.451  1.00 76.14  ? 397 GLN C CB  1 
ATOM 8526  C CG  . GLN C 1 403 ? 36.780  -9.250  36.209  1.00 84.11  ? 397 GLN C CG  1 
ATOM 8527  C CD  . GLN C 1 403 ? 38.289  -9.318  36.073  1.00 91.65  ? 397 GLN C CD  1 
ATOM 8528  O OE1 . GLN C 1 403 ? 38.844  -9.415  34.974  1.00 92.56  ? 397 GLN C OE1 1 
ATOM 8529  N NE2 . GLN C 1 403 ? 38.985  -9.252  37.198  1.00 97.69  ? 397 GLN C NE2 1 
ATOM 8530  N N   . LEU C 1 404 ? 33.908  -10.083 37.971  1.00 64.26  ? 398 LEU C N   1 
ATOM 8531  C CA  . LEU C 1 404 ? 33.697  -10.569 39.328  1.00 52.48  ? 398 LEU C CA  1 
ATOM 8532  C C   . LEU C 1 404 ? 32.232  -10.894 39.604  1.00 46.36  ? 398 LEU C C   1 
ATOM 8533  O O   . LEU C 1 404 ? 31.945  -11.801 40.377  1.00 44.24  ? 398 LEU C O   1 
ATOM 8534  C CB  . LEU C 1 404 ? 34.210  -9.540  40.330  1.00 51.55  ? 398 LEU C CB  1 
ATOM 8535  C CG  . LEU C 1 404 ? 35.691  -9.158  40.233  1.00 51.82  ? 398 LEU C CG  1 
ATOM 8536  C CD1 . LEU C 1 404 ? 36.085  -8.398  41.495  1.00 52.51  ? 398 LEU C CD1 1 
ATOM 8537  C CD2 . LEU C 1 404 ? 36.591  -10.355 40.009  1.00 50.47  ? 398 LEU C CD2 1 
ATOM 8538  N N   . GLY C 1 405 ? 31.313  -10.134 39.008  1.00 46.51  ? 399 GLY C N   1 
ATOM 8539  C CA  . GLY C 1 405 ? 29.914  -10.161 39.409  1.00 51.58  ? 399 GLY C CA  1 
ATOM 8540  C C   . GLY C 1 405 ? 29.664  -9.329  40.676  1.00 57.89  ? 399 GLY C C   1 
ATOM 8541  O O   . GLY C 1 405 ? 30.597  -9.020  41.422  1.00 54.18  ? 399 GLY C O   1 
ATOM 8542  N N   . GLU C 1 406 ? 28.380  -9.004  40.916  1.00 57.94  ? 400 GLU C N   1 
ATOM 8543  C CA  . GLU C 1 406 ? 27.932  -8.124  41.992  1.00 56.57  ? 400 GLU C CA  1 
ATOM 8544  C C   . GLU C 1 406 ? 28.655  -8.399  43.317  1.00 54.37  ? 400 GLU C C   1 
ATOM 8545  O O   . GLU C 1 406 ? 29.250  -7.480  43.872  1.00 52.58  ? 400 GLU C O   1 
ATOM 8546  C CB  . GLU C 1 406 ? 26.410  -8.228  42.139  1.00 61.39  ? 400 GLU C CB  1 
ATOM 8547  C CG  . GLU C 1 406 ? 25.819  -7.287  43.187  1.00 69.08  ? 400 GLU C CG  1 
ATOM 8548  C CD  . GLU C 1 406 ? 24.396  -6.802  42.929  1.00 79.29  ? 400 GLU C CD  1 
ATOM 8549  O OE1 . GLU C 1 406 ? 24.166  -6.156  41.886  1.00 84.94  ? 400 GLU C OE1 1 
ATOM 8550  O OE2 . GLU C 1 406 ? 23.507  -7.043  43.771  1.00 94.51  ? 400 GLU C OE2 1 
ATOM 8551  N N   . TYR C 1 407 ? 28.592  -9.634  43.840  1.00 51.72  ? 401 TYR C N   1 
ATOM 8552  C CA  . TYR C 1 407 ? 29.085  -9.912  45.182  1.00 55.51  ? 401 TYR C CA  1 
ATOM 8553  C C   . TYR C 1 407 ? 30.597  -9.701  45.201  1.00 53.12  ? 401 TYR C C   1 
ATOM 8554  O O   . TYR C 1 407 ? 31.083  -8.884  45.971  1.00 54.96  ? 401 TYR C O   1 
ATOM 8555  C CB  . TYR C 1 407 ? 28.669  -11.292 45.720  1.00 61.71  ? 401 TYR C CB  1 
ATOM 8556  C CG  . TYR C 1 407 ? 29.482  -11.888 46.875  1.00 68.86  ? 401 TYR C CG  1 
ATOM 8557  C CD1 . TYR C 1 407 ? 29.175  -11.646 48.220  1.00 71.07  ? 401 TYR C CD1 1 
ATOM 8558  C CD2 . TYR C 1 407 ? 30.553  -12.736 46.617  1.00 69.67  ? 401 TYR C CD2 1 
ATOM 8559  C CE1 . TYR C 1 407 ? 29.921  -12.200 49.256  1.00 69.01  ? 401 TYR C CE1 1 
ATOM 8560  C CE2 . TYR C 1 407 ? 31.302  -13.294 47.641  1.00 77.34  ? 401 TYR C CE2 1 
ATOM 8561  C CZ  . TYR C 1 407 ? 30.992  -13.031 48.965  1.00 76.30  ? 401 TYR C CZ  1 
ATOM 8562  O OH  . TYR C 1 407 ? 31.790  -13.629 49.911  1.00 74.36  ? 401 TYR C OH  1 
ATOM 8563  N N   . LYS C 1 408 ? 31.342  -10.427 44.365  1.00 55.68  ? 402 LYS C N   1 
ATOM 8564  C CA  . LYS C 1 408 ? 32.797  -10.387 44.444  1.00 63.17  ? 402 LYS C CA  1 
ATOM 8565  C C   . LYS C 1 408 ? 33.294  -8.973  44.148  1.00 67.87  ? 402 LYS C C   1 
ATOM 8566  O O   . LYS C 1 408 ? 34.352  -8.568  44.632  1.00 72.09  ? 402 LYS C O   1 
ATOM 8567  C CB  . LYS C 1 408 ? 33.488  -11.386 43.507  1.00 63.12  ? 402 LYS C CB  1 
ATOM 8568  C CG  . LYS C 1 408 ? 33.750  -12.750 44.113  1.00 71.16  ? 402 LYS C CG  1 
ATOM 8569  C CD  . LYS C 1 408 ? 34.268  -13.797 43.128  1.00 82.95  ? 402 LYS C CD  1 
ATOM 8570  C CE  . LYS C 1 408 ? 34.276  -15.191 43.710  1.00 88.16  ? 402 LYS C CE  1 
ATOM 8571  N NZ  . LYS C 1 408 ? 34.546  -16.250 42.728  1.00 89.42  ? 402 LYS C NZ  1 
ATOM 8572  N N   . PHE C 1 409 ? 32.526  -8.245  43.329  1.00 64.23  ? 403 PHE C N   1 
ATOM 8573  C CA  . PHE C 1 409 ? 32.827  -6.863  43.004  1.00 64.67  ? 403 PHE C CA  1 
ATOM 8574  C C   . PHE C 1 409 ? 32.672  -6.019  44.266  1.00 60.43  ? 403 PHE C C   1 
ATOM 8575  O O   . PHE C 1 409 ? 33.528  -5.185  44.561  1.00 57.17  ? 403 PHE C O   1 
ATOM 8576  C CB  . PHE C 1 409 ? 31.914  -6.389  41.865  1.00 64.90  ? 403 PHE C CB  1 
ATOM 8577  C CG  . PHE C 1 409 ? 32.156  -4.953  41.430  1.00 60.42  ? 403 PHE C CG  1 
ATOM 8578  C CD1 . PHE C 1 409 ? 33.421  -4.539  41.027  1.00 61.73  ? 403 PHE C CD1 1 
ATOM 8579  C CD2 . PHE C 1 409 ? 31.131  -4.019  41.482  1.00 60.68  ? 403 PHE C CD2 1 
ATOM 8580  C CE1 . PHE C 1 409 ? 33.642  -3.228  40.656  1.00 65.31  ? 403 PHE C CE1 1 
ATOM 8581  C CE2 . PHE C 1 409 ? 31.355  -2.709  41.107  1.00 60.64  ? 403 PHE C CE2 1 
ATOM 8582  C CZ  . PHE C 1 409 ? 32.610  -2.315  40.706  1.00 63.67  ? 403 PHE C CZ  1 
ATOM 8583  N N   . GLN C 1 410 ? 31.567  -6.250  44.990  1.00 59.67  ? 404 GLN C N   1 
ATOM 8584  C CA  . GLN C 1 410 ? 31.327  -5.597  46.268  1.00 59.16  ? 404 GLN C CA  1 
ATOM 8585  C C   . GLN C 1 410 ? 32.585  -5.706  47.128  1.00 57.82  ? 404 GLN C C   1 
ATOM 8586  O O   . GLN C 1 410 ? 33.046  -4.711  47.669  1.00 60.69  ? 404 GLN C O   1 
ATOM 8587  C CB  . GLN C 1 410 ? 30.075  -6.142  46.960  1.00 56.78  ? 404 GLN C CB  1 
ATOM 8588  C CG  . GLN C 1 410 ? 28.775  -5.748  46.259  1.00 59.24  ? 404 GLN C CG  1 
ATOM 8589  C CD  . GLN C 1 410 ? 27.520  -6.276  46.928  1.00 57.29  ? 404 GLN C CD  1 
ATOM 8590  O OE1 . GLN C 1 410 ? 27.584  -7.021  47.907  1.00 60.92  ? 404 GLN C OE1 1 
ATOM 8591  N NE2 . GLN C 1 410 ? 26.357  -5.890  46.423  1.00 52.80  ? 404 GLN C NE2 1 
ATOM 8592  N N   . ASN C 1 411 ? 33.173  -6.903  47.179  1.00 57.88  ? 405 ASN C N   1 
ATOM 8593  C CA  . ASN C 1 411 ? 34.322  -7.189  48.026  1.00 58.23  ? 405 ASN C CA  1 
ATOM 8594  C C   . ASN C 1 411 ? 35.528  -6.346  47.607  1.00 53.64  ? 405 ASN C C   1 
ATOM 8595  O O   . ASN C 1 411 ? 36.209  -5.756  48.445  1.00 47.65  ? 405 ASN C O   1 
ATOM 8596  C CB  . ASN C 1 411 ? 34.627  -8.686  48.028  1.00 62.58  ? 405 ASN C CB  1 
ATOM 8597  C CG  . ASN C 1 411 ? 33.462  -9.512  48.530  1.00 67.41  ? 405 ASN C CG  1 
ATOM 8598  O OD1 . ASN C 1 411 ? 32.465  -8.964  49.023  1.00 67.00  ? 405 ASN C OD1 1 
ATOM 8599  N ND2 . ASN C 1 411 ? 33.573  -10.829 48.421  1.00 69.00  ? 405 ASN C ND2 1 
ATOM 8600  N N   . ALA C 1 412 ? 35.799  -6.300  46.304  1.00 54.35  ? 406 ALA C N   1 
ATOM 8601  C CA  . ALA C 1 412 ? 36.906  -5.510  45.801  1.00 55.24  ? 406 ALA C CA  1 
ATOM 8602  C C   . ALA C 1 412 ? 36.739  -4.050  46.222  1.00 59.63  ? 406 ALA C C   1 
ATOM 8603  O O   . ALA C 1 412 ? 37.736  -3.370  46.436  1.00 62.99  ? 406 ALA C O   1 
ATOM 8604  C CB  . ALA C 1 412 ? 36.986  -5.654  44.302  1.00 57.62  ? 406 ALA C CB  1 
ATOM 8605  N N   . LEU C 1 413 ? 35.482  -3.581  46.331  1.00 62.58  ? 407 LEU C N   1 
ATOM 8606  C CA  . LEU C 1 413 ? 35.161  -2.216  46.752  1.00 67.62  ? 407 LEU C CA  1 
ATOM 8607  C C   . LEU C 1 413 ? 35.402  -2.037  48.264  1.00 67.73  ? 407 LEU C C   1 
ATOM 8608  O O   . LEU C 1 413 ? 35.815  -0.962  48.707  1.00 64.56  ? 407 LEU C O   1 
ATOM 8609  C CB  . LEU C 1 413 ? 33.719  -1.819  46.379  1.00 67.77  ? 407 LEU C CB  1 
ATOM 8610  C CG  . LEU C 1 413 ? 33.377  -1.596  44.894  1.00 65.23  ? 407 LEU C CG  1 
ATOM 8611  C CD1 . LEU C 1 413 ? 31.889  -1.334  44.664  1.00 59.53  ? 407 LEU C CD1 1 
ATOM 8612  C CD2 . LEU C 1 413 ? 34.165  -0.450  44.284  1.00 66.29  ? 407 LEU C CD2 1 
ATOM 8613  N N   . LEU C 1 414 ? 35.113  -3.073  49.069  1.00 61.36  ? 408 LEU C N   1 
ATOM 8614  C CA  . LEU C 1 414 ? 35.319  -3.008  50.507  1.00 54.23  ? 408 LEU C CA  1 
ATOM 8615  C C   . LEU C 1 414 ? 36.795  -2.767  50.795  1.00 52.98  ? 408 LEU C C   1 
ATOM 8616  O O   . LEU C 1 414 ? 37.127  -1.976  51.672  1.00 52.94  ? 408 LEU C O   1 
ATOM 8617  C CB  . LEU C 1 414 ? 34.847  -4.279  51.204  1.00 56.01  ? 408 LEU C CB  1 
ATOM 8618  C CG  . LEU C 1 414 ? 33.334  -4.435  51.348  1.00 62.02  ? 408 LEU C CG  1 
ATOM 8619  C CD1 . LEU C 1 414 ? 32.947  -5.888  51.621  1.00 64.84  ? 408 LEU C CD1 1 
ATOM 8620  C CD2 . LEU C 1 414 ? 32.831  -3.524  52.456  1.00 68.97  ? 408 LEU C CD2 1 
ATOM 8621  N N   . VAL C 1 415 ? 37.676  -3.454  50.060  1.00 46.29  ? 409 VAL C N   1 
ATOM 8622  C CA  . VAL C 1 415 ? 39.097  -3.294  50.299  1.00 45.52  ? 409 VAL C CA  1 
ATOM 8623  C C   . VAL C 1 415 ? 39.489  -1.861  49.950  1.00 49.46  ? 409 VAL C C   1 
ATOM 8624  O O   . VAL C 1 415 ? 40.160  -1.197  50.728  1.00 47.98  ? 409 VAL C O   1 
ATOM 8625  C CB  . VAL C 1 415 ? 39.915  -4.328  49.513  1.00 44.37  ? 409 VAL C CB  1 
ATOM 8626  C CG1 . VAL C 1 415 ? 41.413  -4.220  49.794  1.00 45.84  ? 409 VAL C CG1 1 
ATOM 8627  C CG2 . VAL C 1 415 ? 39.417  -5.729  49.813  1.00 46.22  ? 409 VAL C CG2 1 
ATOM 8628  N N   . ARG C 1 416 ? 39.036  -1.393  48.783  1.00 58.09  ? 410 ARG C N   1 
ATOM 8629  C CA  . ARG C 1 416 ? 39.357  -0.070  48.266  1.00 62.76  ? 410 ARG C CA  1 
ATOM 8630  C C   . ARG C 1 416 ? 39.067  0.974   49.338  1.00 62.44  ? 410 ARG C C   1 
ATOM 8631  O O   . ARG C 1 416 ? 39.985  1.640   49.804  1.00 59.61  ? 410 ARG C O   1 
ATOM 8632  C CB  . ARG C 1 416 ? 38.550  0.193   46.983  1.00 67.48  ? 410 ARG C CB  1 
ATOM 8633  C CG  . ARG C 1 416 ? 38.643  1.571   46.341  1.00 66.75  ? 410 ARG C CG  1 
ATOM 8634  C CD  . ARG C 1 416 ? 37.882  1.630   45.014  1.00 68.45  ? 410 ARG C CD  1 
ATOM 8635  N NE  . ARG C 1 416 ? 38.543  0.831   43.975  1.00 73.31  ? 410 ARG C NE  1 
ATOM 8636  C CZ  . ARG C 1 416 ? 38.096  0.586   42.743  1.00 68.67  ? 410 ARG C CZ  1 
ATOM 8637  N NH1 . ARG C 1 416 ? 36.941  1.102   42.344  1.00 60.78  ? 410 ARG C NH1 1 
ATOM 8638  N NH2 . ARG C 1 416 ? 38.810  -0.194  41.931  1.00 65.95  ? 410 ARG C NH2 1 
ATOM 8639  N N   . TYR C 1 417 ? 37.795  1.048   49.750  1.00 63.74  ? 411 TYR C N   1 
ATOM 8640  C CA  . TYR C 1 417 ? 37.278  2.134   50.570  1.00 66.91  ? 411 TYR C CA  1 
ATOM 8641  C C   . TYR C 1 417 ? 37.474  1.909   52.074  1.00 70.39  ? 411 TYR C C   1 
ATOM 8642  O O   . TYR C 1 417 ? 37.023  2.718   52.880  1.00 64.70  ? 411 TYR C O   1 
ATOM 8643  C CB  . TYR C 1 417 ? 35.782  2.248   50.271  1.00 65.35  ? 411 TYR C CB  1 
ATOM 8644  C CG  . TYR C 1 417 ? 35.409  2.711   48.871  1.00 65.41  ? 411 TYR C CG  1 
ATOM 8645  C CD1 . TYR C 1 417 ? 36.212  3.619   48.190  1.00 67.11  ? 411 TYR C CD1 1 
ATOM 8646  C CD2 . TYR C 1 417 ? 34.225  2.293   48.263  1.00 59.94  ? 411 TYR C CD2 1 
ATOM 8647  C CE1 . TYR C 1 417 ? 35.858  4.090   46.940  1.00 65.61  ? 411 TYR C CE1 1 
ATOM 8648  C CE2 . TYR C 1 417 ? 33.867  2.748   47.006  1.00 57.30  ? 411 TYR C CE2 1 
ATOM 8649  C CZ  . TYR C 1 417 ? 34.694  3.642   46.344  1.00 63.67  ? 411 TYR C CZ  1 
ATOM 8650  O OH  . TYR C 1 417 ? 34.428  4.141   45.106  1.00 67.99  ? 411 TYR C OH  1 
ATOM 8651  N N   . THR C 1 418 ? 38.097  0.796   52.471  1.00 74.94  ? 412 THR C N   1 
ATOM 8652  C CA  . THR C 1 418 ? 38.556  0.660   53.843  1.00 75.23  ? 412 THR C CA  1 
ATOM 8653  C C   . THR C 1 418 ? 40.024  1.074   53.904  1.00 77.33  ? 412 THR C C   1 
ATOM 8654  O O   . THR C 1 418 ? 40.478  1.532   54.945  1.00 83.45  ? 412 THR C O   1 
ATOM 8655  C CB  . THR C 1 418 ? 38.348  -0.757  54.376  1.00 71.21  ? 412 THR C CB  1 
ATOM 8656  O OG1 . THR C 1 418 ? 37.085  -1.239  53.936  1.00 68.92  ? 412 THR C OG1 1 
ATOM 8657  C CG2 . THR C 1 418 ? 38.296  -0.787  55.889  1.00 73.21  ? 412 THR C CG2 1 
ATOM 8658  N N   . LYS C 1 419 ? 40.753  0.901   52.790  1.00 76.64  ? 413 LYS C N   1 
ATOM 8659  C CA  . LYS C 1 419 ? 42.131  1.361   52.670  1.00 81.29  ? 413 LYS C CA  1 
ATOM 8660  C C   . LYS C 1 419 ? 42.152  2.882   52.491  1.00 85.74  ? 413 LYS C C   1 
ATOM 8661  O O   . LYS C 1 419 ? 43.172  3.519   52.756  1.00 81.58  ? 413 LYS C O   1 
ATOM 8662  C CB  . LYS C 1 419 ? 42.857  0.703   51.484  1.00 82.02  ? 413 LYS C CB  1 
ATOM 8663  C CG  . LYS C 1 419 ? 43.598  -0.623  51.680  1.00 76.02  ? 413 LYS C CG  1 
ATOM 8664  C CD  . LYS C 1 419 ? 44.087  -1.161  50.337  1.00 79.17  ? 413 LYS C CD  1 
ATOM 8665  C CE  . LYS C 1 419 ? 45.350  -1.964  50.373  1.00 86.29  ? 413 LYS C CE  1 
ATOM 8666  N NZ  . LYS C 1 419 ? 45.110  -3.394  50.575  1.00 91.29  ? 413 LYS C NZ  1 
ATOM 8667  N N   . LYS C 1 420 ? 41.035  3.444   51.998  1.00 90.20  ? 414 LYS C N   1 
ATOM 8668  C CA  . LYS C 1 420 ? 40.900  4.873   51.740  1.00 90.79  ? 414 LYS C CA  1 
ATOM 8669  C C   . LYS C 1 420 ? 40.572  5.602   53.040  1.00 89.42  ? 414 LYS C C   1 
ATOM 8670  O O   . LYS C 1 420 ? 41.282  6.528   53.429  1.00 85.85  ? 414 LYS C O   1 
ATOM 8671  C CB  . LYS C 1 420 ? 39.782  5.153   50.725  1.00 94.52  ? 414 LYS C CB  1 
ATOM 8672  C CG  . LYS C 1 420 ? 39.999  4.582   49.326  1.00 105.83 ? 414 LYS C CG  1 
ATOM 8673  C CD  . LYS C 1 420 ? 40.412  5.567   48.241  1.00 109.70 ? 414 LYS C CD  1 
ATOM 8674  C CE  . LYS C 1 420 ? 40.898  4.845   47.019  1.00 112.91 ? 414 LYS C CE  1 
ATOM 8675  N NZ  . LYS C 1 420 ? 40.941  5.730   45.852  1.00 121.15 ? 414 LYS C NZ  1 
ATOM 8676  N N   . VAL C 1 421 ? 39.483  5.172   53.698  1.00 87.81  ? 415 VAL C N   1 
ATOM 8677  C CA  . VAL C 1 421 ? 38.989  5.821   54.906  1.00 82.75  ? 415 VAL C CA  1 
ATOM 8678  C C   . VAL C 1 421 ? 38.755  4.761   55.998  1.00 85.60  ? 415 VAL C C   1 
ATOM 8679  O O   . VAL C 1 421 ? 37.625  4.487   56.394  1.00 82.29  ? 415 VAL C O   1 
ATOM 8680  C CB  . VAL C 1 421 ? 37.761  6.727   54.601  1.00 68.71  ? 415 VAL C CB  1 
ATOM 8681  C CG1 . VAL C 1 421 ? 37.987  7.544   53.338  1.00 67.63  ? 415 VAL C CG1 1 
ATOM 8682  C CG2 . VAL C 1 421 ? 36.422  6.014   54.461  1.00 60.04  ? 415 VAL C CG2 1 
ATOM 8683  N N   . PRO C 1 422 ? 39.825  4.166   56.586  1.00 84.59  ? 416 PRO C N   1 
ATOM 8684  C CA  . PRO C 1 422 ? 39.671  3.084   57.569  1.00 83.03  ? 416 PRO C CA  1 
ATOM 8685  C C   . PRO C 1 422 ? 38.992  3.483   58.879  1.00 76.47  ? 416 PRO C C   1 
ATOM 8686  O O   . PRO C 1 422 ? 38.491  2.646   59.628  1.00 66.56  ? 416 PRO C O   1 
ATOM 8687  C CB  . PRO C 1 422 ? 41.128  2.626   57.816  1.00 86.04  ? 416 PRO C CB  1 
ATOM 8688  C CG  . PRO C 1 422 ? 41.955  3.854   57.523  1.00 90.19  ? 416 PRO C CG  1 
ATOM 8689  C CD  . PRO C 1 422 ? 41.236  4.524   56.360  1.00 90.10  ? 416 PRO C CD  1 
ATOM 8690  N N   . GLN C 1 423 ? 38.992  4.781   59.162  1.00 79.82  ? 417 GLN C N   1 
ATOM 8691  C CA  . GLN C 1 423 ? 38.557  5.257   60.460  1.00 91.35  ? 417 GLN C CA  1 
ATOM 8692  C C   . GLN C 1 423 ? 37.040  5.076   60.573  1.00 87.07  ? 417 GLN C C   1 
ATOM 8693  O O   . GLN C 1 423 ? 36.497  5.058   61.677  1.00 82.49  ? 417 GLN C O   1 
ATOM 8694  C CB  . GLN C 1 423 ? 39.025  6.700   60.692  1.00 102.63 ? 417 GLN C CB  1 
ATOM 8695  C CG  . GLN C 1 423 ? 40.469  7.011   60.289  1.00 110.21 ? 417 GLN C CG  1 
ATOM 8696  C CD  . GLN C 1 423 ? 40.613  7.591   58.894  1.00 116.88 ? 417 GLN C CD  1 
ATOM 8697  O OE1 . GLN C 1 423 ? 40.174  6.997   57.905  1.00 120.02 ? 417 GLN C OE1 1 
ATOM 8698  N NE2 . GLN C 1 423 ? 41.227  8.762   58.787  1.00 124.03 ? 417 GLN C NE2 1 
ATOM 8699  N N   . VAL C 1 424 ? 36.362  4.931   59.425  1.00 82.90  ? 418 VAL C N   1 
ATOM 8700  C CA  . VAL C 1 424 ? 34.905  4.869   59.385  1.00 90.07  ? 418 VAL C CA  1 
ATOM 8701  C C   . VAL C 1 424 ? 34.418  3.490   59.840  1.00 89.03  ? 418 VAL C C   1 
ATOM 8702  O O   . VAL C 1 424 ? 35.149  2.500   59.759  1.00 88.55  ? 418 VAL C O   1 
ATOM 8703  C CB  . VAL C 1 424 ? 34.367  5.229   57.983  1.00 98.47  ? 418 VAL C CB  1 
ATOM 8704  C CG1 . VAL C 1 424 ? 34.958  4.347   56.892  1.00 100.19 ? 418 VAL C CG1 1 
ATOM 8705  C CG2 . VAL C 1 424 ? 32.842  5.216   57.905  1.00 94.38  ? 418 VAL C CG2 1 
ATOM 8706  N N   . SER C 1 425 ? 33.156  3.449   60.292  1.00 78.43  ? 419 SER C N   1 
ATOM 8707  C CA  . SER C 1 425 ? 32.583  2.333   61.030  1.00 77.49  ? 419 SER C CA  1 
ATOM 8708  C C   . SER C 1 425 ? 32.171  1.186   60.107  1.00 75.87  ? 419 SER C C   1 
ATOM 8709  O O   . SER C 1 425 ? 31.566  1.441   59.078  1.00 89.03  ? 419 SER C O   1 
ATOM 8710  C CB  . SER C 1 425 ? 31.417  2.837   61.831  1.00 77.67  ? 419 SER C CB  1 
ATOM 8711  O OG  . SER C 1 425 ? 30.801  3.926   61.153  1.00 80.23  ? 419 SER C OG  1 
ATOM 8712  N N   . THR C 1 426 ? 32.437  -0.069  60.518  1.00 69.26  ? 420 THR C N   1 
ATOM 8713  C CA  . THR C 1 426 ? 32.431  -1.235  59.638  1.00 65.71  ? 420 THR C CA  1 
ATOM 8714  C C   . THR C 1 426 ? 31.041  -1.483  59.046  1.00 67.15  ? 420 THR C C   1 
ATOM 8715  O O   . THR C 1 426 ? 30.914  -1.698  57.846  1.00 69.47  ? 420 THR C O   1 
ATOM 8716  C CB  . THR C 1 426 ? 32.971  -2.473  60.364  1.00 61.19  ? 420 THR C CB  1 
ATOM 8717  O OG1 . THR C 1 426 ? 34.396  -2.390  60.356  1.00 55.82  ? 420 THR C OG1 1 
ATOM 8718  C CG2 . THR C 1 426 ? 32.606  -3.781  59.680  1.00 57.97  ? 420 THR C CG2 1 
ATOM 8719  N N   . PRO C 1 427 ? 29.944  -1.463  59.831  1.00 69.40  ? 421 PRO C N   1 
ATOM 8720  C CA  . PRO C 1 427 ? 28.603  -1.660  59.265  1.00 69.16  ? 421 PRO C CA  1 
ATOM 8721  C C   . PRO C 1 427 ? 28.268  -0.670  58.150  1.00 78.01  ? 421 PRO C C   1 
ATOM 8722  O O   . PRO C 1 427 ? 27.477  -0.982  57.256  1.00 80.09  ? 421 PRO C O   1 
ATOM 8723  C CB  . PRO C 1 427 ? 27.658  -1.491  60.461  1.00 65.93  ? 421 PRO C CB  1 
ATOM 8724  C CG  . PRO C 1 427 ? 28.548  -1.739  61.666  1.00 76.68  ? 421 PRO C CG  1 
ATOM 8725  C CD  . PRO C 1 427 ? 29.931  -1.230  61.280  1.00 74.70  ? 421 PRO C CD  1 
ATOM 8726  N N   . THR C 1 428 ? 28.864  0.532   58.238  1.00 82.03  ? 422 THR C N   1 
ATOM 8727  C CA  . THR C 1 428 ? 28.709  1.591   57.246  1.00 72.18  ? 422 THR C CA  1 
ATOM 8728  C C   . THR C 1 428 ? 29.429  1.228   55.946  1.00 63.81  ? 422 THR C C   1 
ATOM 8729  O O   . THR C 1 428 ? 28.816  1.301   54.889  1.00 61.92  ? 422 THR C O   1 
ATOM 8730  C CB  . THR C 1 428 ? 29.225  2.908   57.830  1.00 72.64  ? 422 THR C CB  1 
ATOM 8731  O OG1 . THR C 1 428 ? 28.470  3.058   59.032  1.00 74.22  ? 422 THR C OG1 1 
ATOM 8732  C CG2 . THR C 1 428 ? 29.088  4.080   56.873  1.00 67.53  ? 422 THR C CG2 1 
ATOM 8733  N N   . LEU C 1 429 ? 30.709  0.829   56.029  1.00 62.47  ? 423 LEU C N   1 
ATOM 8734  C CA  . LEU C 1 429 ? 31.497  0.433   54.867  1.00 61.51  ? 423 LEU C CA  1 
ATOM 8735  C C   . LEU C 1 429 ? 30.814  -0.714  54.123  1.00 63.93  ? 423 LEU C C   1 
ATOM 8736  O O   . LEU C 1 429 ? 30.752  -0.726  52.897  1.00 62.48  ? 423 LEU C O   1 
ATOM 8737  C CB  . LEU C 1 429 ? 32.903  0.002   55.269  1.00 64.79  ? 423 LEU C CB  1 
ATOM 8738  C CG  . LEU C 1 429 ? 33.834  1.117   55.743  1.00 73.91  ? 423 LEU C CG  1 
ATOM 8739  C CD1 . LEU C 1 429 ? 33.502  1.451   57.180  1.00 80.91  ? 423 LEU C CD1 1 
ATOM 8740  C CD2 . LEU C 1 429 ? 35.300  0.730   55.602  1.00 74.72  ? 423 LEU C CD2 1 
ATOM 8741  N N   . VAL C 1 430 ? 30.287  -1.676  54.882  1.00 65.05  ? 424 VAL C N   1 
ATOM 8742  C CA  . VAL C 1 430 ? 29.616  -2.830  54.314  1.00 67.76  ? 424 VAL C CA  1 
ATOM 8743  C C   . VAL C 1 430 ? 28.246  -2.454  53.743  1.00 70.65  ? 424 VAL C C   1 
ATOM 8744  O O   . VAL C 1 430 ? 27.611  -3.261  53.076  1.00 70.57  ? 424 VAL C O   1 
ATOM 8745  C CB  . VAL C 1 430 ? 29.498  -3.913  55.401  1.00 68.35  ? 424 VAL C CB  1 
ATOM 8746  C CG1 . VAL C 1 430 ? 28.778  -5.159  54.890  1.00 70.01  ? 424 VAL C CG1 1 
ATOM 8747  C CG2 . VAL C 1 430 ? 30.866  -4.286  55.960  1.00 69.56  ? 424 VAL C CG2 1 
ATOM 8748  N N   . GLU C 1 431 ? 27.762  -1.244  54.013  1.00 76.21  ? 425 GLU C N   1 
ATOM 8749  C CA  . GLU C 1 431 ? 26.495  -0.818  53.446  1.00 87.66  ? 425 GLU C CA  1 
ATOM 8750  C C   . GLU C 1 431 ? 26.737  0.086   52.233  1.00 87.41  ? 425 GLU C C   1 
ATOM 8751  O O   . GLU C 1 431 ? 25.973  0.053   51.265  1.00 86.22  ? 425 GLU C O   1 
ATOM 8752  C CB  . GLU C 1 431 ? 25.638  -0.190  54.546  1.00 97.18  ? 425 GLU C CB  1 
ATOM 8753  C CG  . GLU C 1 431 ? 24.223  0.164   54.091  1.00 109.00 ? 425 GLU C CG  1 
ATOM 8754  C CD  . GLU C 1 431 ? 23.505  -0.919  53.298  1.00 123.61 ? 425 GLU C CD  1 
ATOM 8755  O OE1 . GLU C 1 431 ? 23.472  -2.081  53.763  1.00 125.91 ? 425 GLU C OE1 1 
ATOM 8756  O OE2 . GLU C 1 431 ? 22.975  -0.596  52.209  1.00 132.49 ? 425 GLU C OE2 1 
ATOM 8757  N N   . VAL C 1 432 ? 27.802  0.892   52.276  1.00 80.64  ? 426 VAL C N   1 
ATOM 8758  C CA  . VAL C 1 432 ? 28.196  1.658   51.104  1.00 85.72  ? 426 VAL C CA  1 
ATOM 8759  C C   . VAL C 1 432 ? 28.529  0.665   49.989  1.00 88.41  ? 426 VAL C C   1 
ATOM 8760  O O   . VAL C 1 432 ? 27.885  0.683   48.938  1.00 87.46  ? 426 VAL C O   1 
ATOM 8761  C CB  . VAL C 1 432 ? 29.377  2.622   51.337  1.00 80.71  ? 426 VAL C CB  1 
ATOM 8762  C CG1 . VAL C 1 432 ? 29.512  3.630   50.205  1.00 76.17  ? 426 VAL C CG1 1 
ATOM 8763  C CG2 . VAL C 1 432 ? 29.261  3.367   52.656  1.00 87.06  ? 426 VAL C CG2 1 
ATOM 8764  N N   . SER C 1 433 ? 29.510  -0.217  50.255  1.00 79.15  ? 427 SER C N   1 
ATOM 8765  C CA  . SER C 1 433 ? 30.100  -1.076  49.239  1.00 69.72  ? 427 SER C CA  1 
ATOM 8766  C C   . SER C 1 433 ? 29.062  -1.969  48.582  1.00 63.48  ? 427 SER C C   1 
ATOM 8767  O O   . SER C 1 433 ? 29.209  -2.296  47.411  1.00 62.02  ? 427 SER C O   1 
ATOM 8768  C CB  . SER C 1 433 ? 31.218  -1.908  49.779  1.00 74.85  ? 427 SER C CB  1 
ATOM 8769  O OG  . SER C 1 433 ? 32.469  -1.280  49.536  1.00 79.48  ? 427 SER C OG  1 
ATOM 8770  N N   . ARG C 1 434 ? 28.042  -2.369  49.343  1.00 66.78  ? 428 ARG C N   1 
ATOM 8771  C CA  . ARG C 1 434 ? 26.954  -3.173  48.806  1.00 70.60  ? 428 ARG C CA  1 
ATOM 8772  C C   . ARG C 1 434 ? 26.124  -2.337  47.834  1.00 68.52  ? 428 ARG C C   1 
ATOM 8773  O O   . ARG C 1 434 ? 25.863  -2.787  46.726  1.00 61.25  ? 428 ARG C O   1 
ATOM 8774  C CB  . ARG C 1 434 ? 26.096  -3.786  49.921  1.00 71.23  ? 428 ARG C CB  1 
ATOM 8775  C CG  . ARG C 1 434 ? 26.817  -4.899  50.667  1.00 70.91  ? 428 ARG C CG  1 
ATOM 8776  C CD  . ARG C 1 434 ? 25.998  -5.458  51.817  1.00 71.52  ? 428 ARG C CD  1 
ATOM 8777  N NE  . ARG C 1 434 ? 24.888  -6.279  51.324  1.00 64.17  ? 428 ARG C NE  1 
ATOM 8778  C CZ  . ARG C 1 434 ? 25.031  -7.464  50.765  1.00 55.74  ? 428 ARG C CZ  1 
ATOM 8779  N NH1 . ARG C 1 434 ? 26.230  -8.020  50.705  1.00 52.12  ? 428 ARG C NH1 1 
ATOM 8780  N NH2 . ARG C 1 434 ? 23.969  -8.089  50.286  1.00 54.93  ? 428 ARG C NH2 1 
ATOM 8781  N N   . ASN C 1 435 ? 25.735  -1.123  48.246  1.00 74.91  ? 429 ASN C N   1 
ATOM 8782  C CA  . ASN C 1 435 ? 24.960  -0.227  47.396  1.00 83.70  ? 429 ASN C CA  1 
ATOM 8783  C C   . ASN C 1 435 ? 25.719  0.059   46.098  1.00 71.13  ? 429 ASN C C   1 
ATOM 8784  O O   . ASN C 1 435 ? 25.175  -0.118  45.009  1.00 62.14  ? 429 ASN C O   1 
ATOM 8785  C CB  . ASN C 1 435 ? 24.573  1.054   48.134  1.00 94.17  ? 429 ASN C CB  1 
ATOM 8786  C CG  . ASN C 1 435 ? 23.550  0.807   49.220  1.00 98.55  ? 429 ASN C CG  1 
ATOM 8787  O OD1 . ASN C 1 435 ? 23.000  -0.295  49.329  1.00 104.78 ? 429 ASN C OD1 1 
ATOM 8788  N ND2 . ASN C 1 435 ? 23.273  1.817   50.030  1.00 100.97 ? 429 ASN C ND2 1 
ATOM 8789  N N   . LEU C 1 436 ? 26.944  0.542   46.248  1.00 64.35  ? 430 LEU C N   1 
ATOM 8790  C CA  . LEU C 1 436 ? 27.763  0.931   45.080  1.00 63.39  ? 430 LEU C CA  1 
ATOM 8791  C C   . LEU C 1 436 ? 27.941  -0.245  44.113  1.00 63.55  ? 430 LEU C C   1 
ATOM 8792  O O   . LEU C 1 436 ? 27.904  -0.016  42.898  1.00 62.91  ? 430 LEU C O   1 
ATOM 8793  C CB  . LEU C 1 436 ? 29.072  1.424   45.679  1.00 61.50  ? 430 LEU C CB  1 
ATOM 8794  C CG  . LEU C 1 436 ? 29.034  2.819   46.303  1.00 58.18  ? 430 LEU C CG  1 
ATOM 8795  C CD1 . LEU C 1 436 ? 30.443  3.256   46.642  1.00 57.96  ? 430 LEU C CD1 1 
ATOM 8796  C CD2 . LEU C 1 436 ? 28.402  3.779   45.321  1.00 58.41  ? 430 LEU C CD2 1 
ATOM 8797  N N   . GLY C 1 437 ? 28.134  -1.450  44.626  1.00 57.34  ? 431 GLY C N   1 
ATOM 8798  C CA  . GLY C 1 437 ? 28.211  -2.619  43.740  1.00 59.46  ? 431 GLY C CA  1 
ATOM 8799  C C   . GLY C 1 437 ? 26.898  -2.788  43.023  1.00 69.81  ? 431 GLY C C   1 
ATOM 8800  O O   . GLY C 1 437 ? 26.918  -3.132  41.836  1.00 72.12  ? 431 GLY C O   1 
ATOM 8801  N N   . LYS C 1 438 ? 25.792  -2.550  43.719  1.00 76.78  ? 432 LYS C N   1 
ATOM 8802  C CA  . LYS C 1 438 ? 24.454  -2.665  43.097  1.00 79.83  ? 432 LYS C CA  1 
ATOM 8803  C C   . LYS C 1 438 ? 24.313  -1.530  42.098  1.00 71.29  ? 432 LYS C C   1 
ATOM 8804  O O   . LYS C 1 438 ? 23.645  -1.712  41.076  1.00 74.55  ? 432 LYS C O   1 
ATOM 8805  C CB  . LYS C 1 438 ? 23.348  -2.513  44.140  1.00 92.35  ? 432 LYS C CB  1 
ATOM 8806  C CG  . LYS C 1 438 ? 22.817  -3.799  44.754  1.00 102.07 ? 432 LYS C CG  1 
ATOM 8807  C CD  . LYS C 1 438 ? 21.992  -3.554  46.011  1.00 102.06 ? 432 LYS C CD  1 
ATOM 8808  C CE  . LYS C 1 438 ? 22.569  -4.218  47.221  1.00 106.87 ? 432 LYS C CE  1 
ATOM 8809  N NZ  . LYS C 1 438 ? 22.443  -3.382  48.417  1.00 106.93 ? 432 LYS C NZ  1 
ATOM 8810  N N   . VAL C 1 439 ? 24.950  -0.408  42.402  1.00 63.30  ? 433 VAL C N   1 
ATOM 8811  C CA  . VAL C 1 439 ? 24.926  0.726   41.445  1.00 65.79  ? 433 VAL C CA  1 
ATOM 8812  C C   . VAL C 1 439 ? 25.628  0.177   40.212  1.00 68.95  ? 433 VAL C C   1 
ATOM 8813  O O   . VAL C 1 439 ? 25.203  0.537   39.154  1.00 69.52  ? 433 VAL C O   1 
ATOM 8814  C CB  . VAL C 1 439 ? 25.584  2.042   41.896  1.00 68.23  ? 433 VAL C CB  1 
ATOM 8815  C CG1 . VAL C 1 439 ? 25.753  3.030   40.750  1.00 66.80  ? 433 VAL C CG1 1 
ATOM 8816  C CG2 . VAL C 1 439 ? 24.833  2.686   43.052  1.00 69.84  ? 433 VAL C CG2 1 
ATOM 8817  N N   . GLY C 1 440 ? 26.697  -0.595  40.391  1.00 61.97  ? 434 GLY C N   1 
ATOM 8818  C CA  . GLY C 1 440 ? 27.434  -1.180  39.263  1.00 58.87  ? 434 GLY C CA  1 
ATOM 8819  C C   . GLY C 1 440 ? 26.551  -2.120  38.495  1.00 62.97  ? 434 GLY C C   1 
ATOM 8820  O O   . GLY C 1 440 ? 26.672  -2.161  37.270  1.00 65.79  ? 434 GLY C O   1 
ATOM 8821  N N   . SER C 1 441 ? 25.737  -2.912  39.184  1.00 71.27  ? 435 SER C N   1 
ATOM 8822  C CA  . SER C 1 441 ? 24.931  -3.846  38.376  1.00 81.59  ? 435 SER C CA  1 
ATOM 8823  C C   . SER C 1 441 ? 24.057  -2.960  37.516  1.00 87.48  ? 435 SER C C   1 
ATOM 8824  O O   . SER C 1 441 ? 23.861  -3.282  36.338  1.00 100.83 ? 435 SER C O   1 
ATOM 8825  C CB  . SER C 1 441 ? 24.084  -4.721  39.231  1.00 83.10  ? 435 SER C CB  1 
ATOM 8826  O OG  . SER C 1 441 ? 22.723  -4.324  39.158  1.00 89.50  ? 435 SER C OG  1 
ATOM 8827  N N   . LYS C 1 442 ? 23.523  -1.906  38.114  1.00 87.36  ? 436 LYS C N   1 
ATOM 8828  C CA  . LYS C 1 442 ? 22.823  -0.925  37.266  1.00 99.53  ? 436 LYS C CA  1 
ATOM 8829  C C   . LYS C 1 442 ? 23.898  -0.183  36.465  1.00 98.58  ? 436 LYS C C   1 
ATOM 8830  O O   . LYS C 1 442 ? 25.009  -0.095  36.942  1.00 108.19 ? 436 LYS C O   1 
ATOM 8831  C CB  . LYS C 1 442 ? 21.924  -0.053  38.147  1.00 102.85 ? 436 LYS C CB  1 
ATOM 8832  C CG  . LYS C 1 442 ? 20.508  -0.566  38.330  1.00 103.15 ? 436 LYS C CG  1 
ATOM 8833  C CD  . LYS C 1 442 ? 20.375  -1.534  39.498  1.00 102.66 ? 436 LYS C CD  1 
ATOM 8834  C CE  . LYS C 1 442 ? 19.883  -0.857  40.733  1.00 104.61 ? 436 LYS C CE  1 
ATOM 8835  N NZ  . LYS C 1 442 ? 18.469  -0.492  40.618  1.00 109.61 ? 436 LYS C NZ  1 
ATOM 8836  N N   . CYS C 1 443 ? 23.696  0.085   35.202  1.00 83.89  ? 437 CYS C N   1 
ATOM 8837  C CA  . CYS C 1 443 ? 24.554  0.982   34.393  1.00 78.19  ? 437 CYS C CA  1 
ATOM 8838  C C   . CYS C 1 443 ? 25.773  0.277   33.802  1.00 69.13  ? 437 CYS C C   1 
ATOM 8839  O O   . CYS C 1 443 ? 26.369  0.879   32.915  1.00 67.05  ? 437 CYS C O   1 
ATOM 8840  C CB  . CYS C 1 443 ? 25.145  2.129   35.218  1.00 75.62  ? 437 CYS C CB  1 
ATOM 8841  S SG  . CYS C 1 443 ? 24.063  3.012   36.383  1.00 83.67  ? 437 CYS C SG  1 
ATOM 8842  N N   . CYS C 1 444 ? 26.071  -0.971  34.144  1.00 58.67  ? 438 CYS C N   1 
ATOM 8843  C CA  . CYS C 1 444 ? 27.119  -1.688  33.375  1.00 61.59  ? 438 CYS C CA  1 
ATOM 8844  C C   . CYS C 1 444 ? 26.303  -2.526  32.396  1.00 56.87  ? 438 CYS C C   1 
ATOM 8845  O O   . CYS C 1 444 ? 26.855  -2.978  31.388  1.00 49.99  ? 438 CYS C O   1 
ATOM 8846  C CB  . CYS C 1 444 ? 28.095  -2.438  34.274  1.00 66.12  ? 438 CYS C CB  1 
ATOM 8847  S SG  . CYS C 1 444 ? 29.325  -1.449  35.168  1.00 71.55  ? 438 CYS C SG  1 
ATOM 8848  N N   . LYS C 1 445 ? 25.041  -2.753  32.738  1.00 60.11  ? 439 LYS C N   1 
ATOM 8849  C CA  . LYS C 1 445 ? 24.070  -3.414  31.845  1.00 66.88  ? 439 LYS C CA  1 
ATOM 8850  C C   . LYS C 1 445 ? 23.905  -2.496  30.661  1.00 67.12  ? 439 LYS C C   1 
ATOM 8851  O O   . LYS C 1 445 ? 23.785  -2.966  29.521  1.00 70.30  ? 439 LYS C O   1 
ATOM 8852  C CB  . LYS C 1 445 ? 22.747  -3.426  32.605  1.00 74.82  ? 439 LYS C CB  1 
ATOM 8853  C CG  . LYS C 1 445 ? 21.533  -3.936  31.840  1.00 84.62  ? 439 LYS C CG  1 
ATOM 8854  C CD  . LYS C 1 445 ? 20.570  -2.846  31.381  1.00 94.08  ? 439 LYS C CD  1 
ATOM 8855  C CE  . LYS C 1 445 ? 19.526  -3.339  30.429  1.00 88.84  ? 439 LYS C CE  1 
ATOM 8856  N NZ  . LYS C 1 445 ? 19.642  -2.714  29.110  1.00 82.18  ? 439 LYS C NZ  1 
ATOM 8857  N N   . HIS C 1 446 ? 23.879  -1.218  30.970  1.00 71.80  ? 440 HIS C N   1 
ATOM 8858  C CA  . HIS C 1 446 ? 23.599  -0.165  29.981  1.00 68.83  ? 440 HIS C CA  1 
ATOM 8859  C C   . HIS C 1 446 ? 24.686  0.006   28.938  1.00 60.49  ? 440 HIS C C   1 
ATOM 8860  O O   . HIS C 1 446 ? 25.883  -0.217  29.154  1.00 49.59  ? 440 HIS C O   1 
ATOM 8861  C CB  . HIS C 1 446 ? 23.378  1.159   30.715  1.00 71.40  ? 440 HIS C CB  1 
ATOM 8862  C CG  . HIS C 1 446 ? 22.005  1.326   31.268  1.00 67.12  ? 440 HIS C CG  1 
ATOM 8863  N ND1 . HIS C 1 446 ? 20.884  0.839   30.637  1.00 69.24  ? 440 HIS C ND1 1 
ATOM 8864  C CD2 . HIS C 1 446 ? 21.574  1.918   32.380  1.00 59.18  ? 440 HIS C CD2 1 
ATOM 8865  C CE1 . HIS C 1 446 ? 19.817  1.135   31.359  1.00 66.84  ? 440 HIS C CE1 1 
ATOM 8866  N NE2 . HIS C 1 446 ? 20.215  1.791   32.420  1.00 65.18  ? 440 HIS C NE2 1 
ATOM 8867  N N   . PRO C 1 447 ? 24.253  0.452   27.758  1.00 62.16  ? 441 PRO C N   1 
ATOM 8868  C CA  . PRO C 1 447 ? 25.158  0.698   26.667  1.00 57.84  ? 441 PRO C CA  1 
ATOM 8869  C C   . PRO C 1 447 ? 25.925  1.850   27.198  1.00 58.88  ? 441 PRO C C   1 
ATOM 8870  O O   . PRO C 1 447 ? 25.368  2.642   27.955  1.00 54.05  ? 441 PRO C O   1 
ATOM 8871  C CB  . PRO C 1 447 ? 24.200  1.064   25.563  1.00 58.01  ? 441 PRO C CB  1 
ATOM 8872  C CG  . PRO C 1 447 ? 22.979  1.592   26.256  1.00 56.27  ? 441 PRO C CG  1 
ATOM 8873  C CD  . PRO C 1 447 ? 22.857  0.650   27.421  1.00 59.41  ? 441 PRO C CD  1 
ATOM 8874  N N   . GLU C 1 448 ? 27.146  2.048   26.743  1.00 72.70  ? 442 GLU C N   1 
ATOM 8875  C CA  . GLU C 1 448 ? 28.104  2.986   27.369  1.00 74.59  ? 442 GLU C CA  1 
ATOM 8876  C C   . GLU C 1 448 ? 27.540  4.404   27.352  1.00 72.32  ? 442 GLU C C   1 
ATOM 8877  O O   . GLU C 1 448 ? 27.820  5.133   28.310  1.00 65.45  ? 442 GLU C O   1 
ATOM 8878  C CB  . GLU C 1 448 ? 29.434  2.843   26.643  1.00 81.96  ? 442 GLU C CB  1 
ATOM 8879  C CG  . GLU C 1 448 ? 29.952  1.407   26.622  1.00 86.62  ? 442 GLU C CG  1 
ATOM 8880  C CD  . GLU C 1 448 ? 29.669  0.616   25.356  1.00 90.87  ? 442 GLU C CD  1 
ATOM 8881  O OE1 . GLU C 1 448 ? 28.834  1.071   24.552  1.00 91.50  ? 442 GLU C OE1 1 
ATOM 8882  O OE2 . GLU C 1 448 ? 30.281  -0.455  25.172  1.00 82.38  ? 442 GLU C OE2 1 
ATOM 8883  N N   . ALA C 1 449 ? 26.839  4.818   26.315  1.00 79.23  ? 443 ALA C N   1 
ATOM 8884  C CA  . ALA C 1 449 ? 26.397  6.225   26.265  1.00 74.61  ? 443 ALA C CA  1 
ATOM 8885  C C   . ALA C 1 449 ? 25.482  6.533   27.451  1.00 72.96  ? 443 ALA C C   1 
ATOM 8886  O O   . ALA C 1 449 ? 25.565  7.663   27.951  1.00 74.47  ? 443 ALA C O   1 
ATOM 8887  C CB  . ALA C 1 449 ? 25.646  6.410   24.986  1.00 77.42  ? 443 ALA C CB  1 
ATOM 8888  N N   . LYS C 1 450 ? 24.596  5.628   27.838  1.00 60.70  ? 444 LYS C N   1 
ATOM 8889  C CA  . LYS C 1 450 ? 23.675  5.781   29.002  1.00 55.72  ? 444 LYS C CA  1 
ATOM 8890  C C   . LYS C 1 450 ? 24.412  5.893   30.354  1.00 53.29  ? 444 LYS C C   1 
ATOM 8891  O O   . LYS C 1 450 ? 23.862  6.568   31.232  1.00 40.13  ? 444 LYS C O   1 
ATOM 8892  C CB  . LYS C 1 450 ? 22.569  4.730   28.900  1.00 56.67  ? 444 LYS C CB  1 
ATOM 8893  C CG  . LYS C 1 450 ? 21.755  4.820   27.620  1.00 64.08  ? 444 LYS C CG  1 
ATOM 8894  C CD  . LYS C 1 450 ? 20.251  4.870   27.851  1.00 65.93  ? 444 LYS C CD  1 
ATOM 8895  C CE  . LYS C 1 450 ? 19.488  4.801   26.569  1.00 72.95  ? 444 LYS C CE  1 
ATOM 8896  N NZ  . LYS C 1 450 ? 18.044  4.920   26.784  1.00 79.22  ? 444 LYS C NZ  1 
ATOM 8897  N N   . ARG C 1 451 ? 25.512  5.178   30.580  1.00 55.36  ? 445 ARG C N   1 
ATOM 8898  C CA  . ARG C 1 451 ? 26.137  5.033   31.925  1.00 56.29  ? 445 ARG C CA  1 
ATOM 8899  C C   . ARG C 1 451 ? 26.672  6.264   32.676  1.00 54.79  ? 445 ARG C C   1 
ATOM 8900  O O   . ARG C 1 451 ? 26.478  6.286   33.894  1.00 55.23  ? 445 ARG C O   1 
ATOM 8901  C CB  . ARG C 1 451 ? 27.402  4.214   31.669  1.00 53.68  ? 445 ARG C CB  1 
ATOM 8902  C CG  . ARG C 1 451 ? 27.198  2.997   30.783  1.00 59.11  ? 445 ARG C CG  1 
ATOM 8903  C CD  . ARG C 1 451 ? 28.396  2.072   30.833  1.00 61.37  ? 445 ARG C CD  1 
ATOM 8904  N NE  . ARG C 1 451 ? 28.049  0.753   30.298  1.00 63.27  ? 445 ARG C NE  1 
ATOM 8905  C CZ  . ARG C 1 451 ? 28.931  -0.116  29.840  1.00 71.24  ? 445 ARG C CZ  1 
ATOM 8906  N NH1 . ARG C 1 451 ? 30.218  0.084   30.042  1.00 73.03  ? 445 ARG C NH1 1 
ATOM 8907  N NH2 . ARG C 1 451 ? 28.523  -1.181  29.179  1.00 79.32  ? 445 ARG C NH2 1 
ATOM 8908  N N   . MET C 1 452 ? 27.336  7.232   32.061  1.00 58.89  ? 446 MET C N   1 
ATOM 8909  C CA  . MET C 1 452 ? 27.810  8.363   32.903  1.00 60.44  ? 446 MET C CA  1 
ATOM 8910  C C   . MET C 1 452 ? 26.622  9.098   33.518  1.00 54.61  ? 446 MET C C   1 
ATOM 8911  O O   . MET C 1 452 ? 26.692  9.429   34.706  1.00 50.03  ? 446 MET C O   1 
ATOM 8912  C CB  . MET C 1 452 ? 28.634  9.371   32.099  1.00 63.30  ? 446 MET C CB  1 
ATOM 8913  C CG  . MET C 1 452 ? 29.595  10.169  32.949  1.00 69.32  ? 446 MET C CG  1 
ATOM 8914  S SD  . MET C 1 452 ? 30.574  11.340  31.993  1.00 76.48  ? 446 MET C SD  1 
ATOM 8915  C CE  . MET C 1 452 ? 31.790  10.233  31.273  1.00 78.11  ? 446 MET C CE  1 
ATOM 8916  N N   . PRO C 1 453 ? 25.527  9.351   32.787  1.00 50.33  ? 447 PRO C N   1 
ATOM 8917  C CA  . PRO C 1 453 ? 24.353  9.914   33.419  1.00 49.27  ? 447 PRO C CA  1 
ATOM 8918  C C   . PRO C 1 453 ? 23.718  9.027   34.475  1.00 51.70  ? 447 PRO C C   1 
ATOM 8919  O O   . PRO C 1 453 ? 23.281  9.551   35.502  1.00 53.64  ? 447 PRO C O   1 
ATOM 8920  C CB  . PRO C 1 453 ? 23.549  9.984   32.153  1.00 53.20  ? 447 PRO C CB  1 
ATOM 8921  C CG  . PRO C 1 453 ? 24.523  10.446  31.125  1.00 53.26  ? 447 PRO C CG  1 
ATOM 8922  C CD  . PRO C 1 453 ? 25.451  9.294   31.340  1.00 53.93  ? 447 PRO C CD  1 
ATOM 8923  N N   . CYS C 1 454 ? 23.632  7.722   34.225  1.00 55.87  ? 448 CYS C N   1 
ATOM 8924  C CA  . CYS C 1 454 ? 23.086  6.758   35.208  1.00 55.91  ? 448 CYS C CA  1 
ATOM 8925  C C   . CYS C 1 454 ? 23.942  6.706   36.472  1.00 52.25  ? 448 CYS C C   1 
ATOM 8926  O O   . CYS C 1 454 ? 23.370  6.727   37.563  1.00 58.25  ? 448 CYS C O   1 
ATOM 8927  C CB  . CYS C 1 454 ? 23.158  5.384   34.548  1.00 61.29  ? 448 CYS C CB  1 
ATOM 8928  S SG  . CYS C 1 454 ? 22.500  3.940   35.426  1.00 66.72  ? 448 CYS C SG  1 
ATOM 8929  N N   . ALA C 1 455 ? 25.261  6.700   36.328  1.00 46.33  ? 449 ALA C N   1 
ATOM 8930  C CA  . ALA C 1 455 ? 26.165  6.668   37.492  1.00 44.69  ? 449 ALA C CA  1 
ATOM 8931  C C   . ALA C 1 455 ? 26.033  7.918   38.342  1.00 49.32  ? 449 ALA C C   1 
ATOM 8932  O O   . ALA C 1 455 ? 25.978  7.806   39.564  1.00 53.74  ? 449 ALA C O   1 
ATOM 8933  C CB  . ALA C 1 455 ? 27.570  6.518   37.010  1.00 43.70  ? 449 ALA C CB  1 
ATOM 8934  N N   . GLU C 1 456 ? 25.924  9.069   37.694  1.00 52.42  ? 450 GLU C N   1 
ATOM 8935  C CA  . GLU C 1 456 ? 25.905  10.332  38.457  1.00 57.65  ? 450 GLU C CA  1 
ATOM 8936  C C   . GLU C 1 456 ? 24.601  10.330  39.214  1.00 60.40  ? 450 GLU C C   1 
ATOM 8937  O O   . GLU C 1 456 ? 24.565  10.723  40.386  1.00 67.08  ? 450 GLU C O   1 
ATOM 8938  C CB  . GLU C 1 456 ? 25.955  11.517  37.504  1.00 65.17  ? 450 GLU C CB  1 
ATOM 8939  C CG  . GLU C 1 456 ? 25.016  12.660  37.875  1.00 65.55  ? 450 GLU C CG  1 
ATOM 8940  C CD  . GLU C 1 456 ? 24.783  13.642  36.746  1.00 66.57  ? 450 GLU C CD  1 
ATOM 8941  O OE1 . GLU C 1 456 ? 24.047  13.307  35.798  1.00 62.13  ? 450 GLU C OE1 1 
ATOM 8942  O OE2 . GLU C 1 456 ? 25.341  14.749  36.822  1.00 66.49  ? 450 GLU C OE2 1 
ATOM 8943  N N   . ASP C 1 457 ? 23.575  9.852   38.541  1.00 57.23  ? 451 ASP C N   1 
ATOM 8944  C CA  . ASP C 1 457 ? 22.304  9.752   39.223  1.00 58.84  ? 451 ASP C CA  1 
ATOM 8945  C C   . ASP C 1 457 ? 22.452  8.963   40.529  1.00 68.27  ? 451 ASP C C   1 
ATOM 8946  O O   . ASP C 1 457 ? 22.214  9.496   41.613  1.00 68.08  ? 451 ASP C O   1 
ATOM 8947  C CB  . ASP C 1 457 ? 21.274  9.172   38.282  1.00 61.92  ? 451 ASP C CB  1 
ATOM 8948  C CG  . ASP C 1 457 ? 19.877  9.136   38.867  1.00 79.11  ? 451 ASP C CG  1 
ATOM 8949  O OD1 . ASP C 1 457 ? 19.627  8.253   39.727  1.00 88.96  ? 451 ASP C OD1 1 
ATOM 8950  O OD2 . ASP C 1 457 ? 19.073  10.018  38.483  1.00 91.24  ? 451 ASP C OD2 1 
ATOM 8951  N N   . TYR C 1 458 ? 22.862  7.689   40.430  1.00 72.36  ? 452 TYR C N   1 
ATOM 8952  C CA  . TYR C 1 458 ? 22.849  6.787   41.574  1.00 64.30  ? 452 TYR C CA  1 
ATOM 8953  C C   . TYR C 1 458 ? 23.897  7.215   42.594  1.00 57.45  ? 452 TYR C C   1 
ATOM 8954  O O   . TYR C 1 458 ? 23.623  7.148   43.790  1.00 50.77  ? 452 TYR C O   1 
ATOM 8955  C CB  . TYR C 1 458 ? 23.035  5.324   41.156  1.00 63.26  ? 452 TYR C CB  1 
ATOM 8956  C CG  . TYR C 1 458 ? 21.750  4.740   40.596  1.00 61.59  ? 452 TYR C CG  1 
ATOM 8957  C CD1 . TYR C 1 458 ? 20.655  4.533   41.417  1.00 65.54  ? 452 TYR C CD1 1 
ATOM 8958  C CD2 . TYR C 1 458 ? 21.616  4.433   39.251  1.00 67.50  ? 452 TYR C CD2 1 
ATOM 8959  C CE1 . TYR C 1 458 ? 19.463  4.032   40.924  1.00 71.33  ? 452 TYR C CE1 1 
ATOM 8960  C CE2 . TYR C 1 458 ? 20.429  3.929   38.740  1.00 72.23  ? 452 TYR C CE2 1 
ATOM 8961  C CZ  . TYR C 1 458 ? 19.350  3.728   39.581  1.00 73.59  ? 452 TYR C CZ  1 
ATOM 8962  O OH  . TYR C 1 458 ? 18.176  3.228   39.104  1.00 75.47  ? 452 TYR C OH  1 
ATOM 8963  N N   . LEU C 1 459 ? 25.056  7.664   42.095  1.00 51.34  ? 453 LEU C N   1 
ATOM 8964  C CA  . LEU C 1 459 ? 26.206  7.974   42.925  1.00 56.86  ? 453 LEU C CA  1 
ATOM 8965  C C   . LEU C 1 459 ? 25.964  9.217   43.787  1.00 61.60  ? 453 LEU C C   1 
ATOM 8966  O O   . LEU C 1 459 ? 26.547  9.369   44.859  1.00 64.08  ? 453 LEU C O   1 
ATOM 8967  C CB  . LEU C 1 459 ? 27.427  8.193   42.037  1.00 60.89  ? 453 LEU C CB  1 
ATOM 8968  C CG  . LEU C 1 459 ? 28.670  7.380   42.405  1.00 63.40  ? 453 LEU C CG  1 
ATOM 8969  C CD1 . LEU C 1 459 ? 28.537  6.078   41.647  1.00 61.37  ? 453 LEU C CD1 1 
ATOM 8970  C CD2 . LEU C 1 459 ? 30.002  8.081   42.120  1.00 61.19  ? 453 LEU C CD2 1 
ATOM 8971  N N   . SER C 1 460 ? 25.147  10.155  43.312  1.00 65.41  ? 454 SER C N   1 
ATOM 8972  C CA  . SER C 1 460 ? 24.953  11.385  44.064  1.00 75.07  ? 454 SER C CA  1 
ATOM 8973  C C   . SER C 1 460 ? 24.061  11.146  45.291  1.00 77.35  ? 454 SER C C   1 
ATOM 8974  O O   . SER C 1 460 ? 24.222  11.804  46.321  1.00 73.89  ? 454 SER C O   1 
ATOM 8975  C CB  . SER C 1 460 ? 24.437  12.476  43.170  1.00 74.73  ? 454 SER C CB  1 
ATOM 8976  O OG  . SER C 1 460 ? 23.350  11.994  42.401  1.00 83.57  ? 454 SER C OG  1 
ATOM 8977  N N   . VAL C 1 461 ? 23.135  10.183  45.191  1.00 83.73  ? 455 VAL C N   1 
ATOM 8978  C CA  . VAL C 1 461 ? 22.355  9.741   46.340  1.00 90.05  ? 455 VAL C CA  1 
ATOM 8979  C C   . VAL C 1 461 ? 23.314  9.237   47.417  1.00 85.91  ? 455 VAL C C   1 
ATOM 8980  O O   . VAL C 1 461 ? 23.179  9.595   48.584  1.00 98.93  ? 455 VAL C O   1 
ATOM 8981  C CB  . VAL C 1 461 ? 21.295  8.669   45.989  1.00 90.77  ? 455 VAL C CB  1 
ATOM 8982  C CG1 . VAL C 1 461 ? 20.745  7.948   47.220  1.00 88.28  ? 455 VAL C CG1 1 
ATOM 8983  C CG2 . VAL C 1 461 ? 20.144  9.251   45.179  1.00 89.18  ? 455 VAL C CG2 1 
ATOM 8984  N N   . VAL C 1 462 ? 24.286  8.413   47.019  1.00 72.83  ? 456 VAL C N   1 
ATOM 8985  C CA  . VAL C 1 462 ? 25.098  7.701   47.988  1.00 74.57  ? 456 VAL C CA  1 
ATOM 8986  C C   . VAL C 1 462 ? 26.031  8.697   48.665  1.00 80.54  ? 456 VAL C C   1 
ATOM 8987  O O   . VAL C 1 462 ? 26.224  8.618   49.877  1.00 82.13  ? 456 VAL C O   1 
ATOM 8988  C CB  . VAL C 1 462 ? 25.882  6.532   47.373  1.00 72.44  ? 456 VAL C CB  1 
ATOM 8989  C CG1 . VAL C 1 462 ? 26.332  5.552   48.451  1.00 80.01  ? 456 VAL C CG1 1 
ATOM 8990  C CG2 . VAL C 1 462 ? 25.062  5.806   46.317  1.00 72.90  ? 456 VAL C CG2 1 
ATOM 8991  N N   . LEU C 1 463 ? 26.542  9.622   47.869  1.00 81.86  ? 457 LEU C N   1 
ATOM 8992  C CA  . LEU C 1 463 ? 27.436  10.648  48.435  1.00 85.24  ? 457 LEU C CA  1 
ATOM 8993  C C   . LEU C 1 463 ? 26.590  11.577  49.299  1.00 88.45  ? 457 LEU C C   1 
ATOM 8994  O O   . LEU C 1 463 ? 27.095  12.039  50.329  1.00 95.41  ? 457 LEU C O   1 
ATOM 8995  C CB  . LEU C 1 463 ? 28.134  11.375  47.298  1.00 86.78  ? 457 LEU C CB  1 
ATOM 8996  C CG  . LEU C 1 463 ? 29.253  10.584  46.616  1.00 92.55  ? 457 LEU C CG  1 
ATOM 8997  C CD1 . LEU C 1 463 ? 30.089  11.464  45.709  1.00 86.24  ? 457 LEU C CD1 1 
ATOM 8998  C CD2 . LEU C 1 463 ? 30.122  9.928   47.667  1.00 97.58  ? 457 LEU C CD2 1 
ATOM 8999  N N   . ASN C 1 464 ? 25.355  11.856  48.900  1.00 85.85  ? 458 ASN C N   1 
ATOM 9000  C CA  . ASN C 1 464 ? 24.569  12.702  49.821  1.00 85.90  ? 458 ASN C CA  1 
ATOM 9001  C C   . ASN C 1 464 ? 24.363  11.990  51.151  1.00 82.75  ? 458 ASN C C   1 
ATOM 9002  O O   . ASN C 1 464 ? 24.578  12.619  52.198  1.00 83.89  ? 458 ASN C O   1 
ATOM 9003  C CB  . ASN C 1 464 ? 23.175  12.902  49.251  1.00 82.78  ? 458 ASN C CB  1 
ATOM 9004  C CG  . ASN C 1 464 ? 22.259  13.688  50.156  1.00 86.46  ? 458 ASN C CG  1 
ATOM 9005  O OD1 . ASN C 1 464 ? 22.683  14.666  50.780  1.00 91.36  ? 458 ASN C OD1 1 
ATOM 9006  N ND2 . ASN C 1 464 ? 20.998  13.291  50.224  1.00 79.91  ? 458 ASN C ND2 1 
ATOM 9007  N N   . GLN C 1 465 ? 24.039  10.702  51.109  1.00 74.66  ? 459 GLN C N   1 
ATOM 9008  C CA  . GLN C 1 465 ? 23.751  10.020  52.386  1.00 72.20  ? 459 GLN C CA  1 
ATOM 9009  C C   . GLN C 1 465 ? 25.012  9.998   53.243  1.00 70.15  ? 459 GLN C C   1 
ATOM 9010  O O   . GLN C 1 465 ? 24.934  10.238  54.455  1.00 68.36  ? 459 GLN C O   1 
ATOM 9011  C CB  . GLN C 1 465 ? 23.241  8.617   52.079  1.00 77.34  ? 459 GLN C CB  1 
ATOM 9012  C CG  . GLN C 1 465 ? 21.838  8.584   51.485  1.00 84.88  ? 459 GLN C CG  1 
ATOM 9013  C CD  . GLN C 1 465 ? 21.476  7.245   50.883  1.00 93.20  ? 459 GLN C CD  1 
ATOM 9014  O OE1 . GLN C 1 465 ? 22.337  6.392   50.644  1.00 96.83  ? 459 GLN C OE1 1 
ATOM 9015  N NE2 . GLN C 1 465 ? 20.190  7.046   50.633  1.00 85.71  ? 459 GLN C NE2 1 
ATOM 9016  N N   . LEU C 1 466 ? 26.135  9.712   52.603  1.00 67.40  ? 460 LEU C N   1 
ATOM 9017  C CA  . LEU C 1 466 ? 27.386  9.625   53.376  1.00 65.87  ? 460 LEU C CA  1 
ATOM 9018  C C   . LEU C 1 466 ? 27.690  10.989  53.963  1.00 68.72  ? 460 LEU C C   1 
ATOM 9019  O O   . LEU C 1 466 ? 28.100  11.051  55.123  1.00 88.26  ? 460 LEU C O   1 
ATOM 9020  C CB  . LEU C 1 466 ? 28.508  9.192   52.440  1.00 66.02  ? 460 LEU C CB  1 
ATOM 9021  C CG  . LEU C 1 466 ? 28.788  7.692   52.347  1.00 73.16  ? 460 LEU C CG  1 
ATOM 9022  C CD1 . LEU C 1 466 ? 27.508  6.882   52.393  1.00 79.54  ? 460 LEU C CD1 1 
ATOM 9023  C CD2 . LEU C 1 466 ? 29.545  7.423   51.065  1.00 77.53  ? 460 LEU C CD2 1 
ATOM 9024  N N   . CYS C 1 467 ? 27.504  12.038  53.170  1.00 70.31  ? 461 CYS C N   1 
ATOM 9025  C CA  . CYS C 1 467 ? 27.898  13.382  53.667  1.00 72.41  ? 461 CYS C CA  1 
ATOM 9026  C C   . CYS C 1 467 ? 27.047  13.787  54.882  1.00 65.55  ? 461 CYS C C   1 
ATOM 9027  O O   . CYS C 1 467 ? 27.600  14.357  55.828  1.00 55.78  ? 461 CYS C O   1 
ATOM 9028  C CB  . CYS C 1 467 ? 27.975  14.359  52.497  1.00 69.38  ? 461 CYS C CB  1 
ATOM 9029  S SG  . CYS C 1 467 ? 29.458  14.130  51.479  1.00 63.96  ? 461 CYS C SG  1 
ATOM 9030  N N   . VAL C 1 468 ? 25.747  13.520  54.834  1.00 64.93  ? 462 VAL C N   1 
ATOM 9031  C CA  . VAL C 1 468 ? 24.915  13.796  56.032  1.00 70.88  ? 462 VAL C CA  1 
ATOM 9032  C C   . VAL C 1 468 ? 25.338  12.921  57.219  1.00 83.29  ? 462 VAL C C   1 
ATOM 9033  O O   . VAL C 1 468 ? 25.453  13.444  58.338  1.00 92.60  ? 462 VAL C O   1 
ATOM 9034  C CB  . VAL C 1 468 ? 23.474  13.487  55.607  1.00 65.05  ? 462 VAL C CB  1 
ATOM 9035  C CG1 . VAL C 1 468 ? 22.519  13.547  56.786  1.00 64.98  ? 462 VAL C CG1 1 
ATOM 9036  C CG2 . VAL C 1 468 ? 23.009  14.396  54.480  1.00 60.94  ? 462 VAL C CG2 1 
ATOM 9037  N N   . LEU C 1 469 ? 25.598  11.640  56.966  1.00 82.82  ? 463 LEU C N   1 
ATOM 9038  C CA  . LEU C 1 469 ? 25.988  10.719  58.060  1.00 77.67  ? 463 LEU C CA  1 
ATOM 9039  C C   . LEU C 1 469 ? 27.317  11.152  58.659  1.00 76.90  ? 463 LEU C C   1 
ATOM 9040  O O   . LEU C 1 469 ? 27.446  11.144  59.887  1.00 86.58  ? 463 LEU C O   1 
ATOM 9041  C CB  . LEU C 1 469 ? 26.080  9.278   57.562  1.00 79.91  ? 463 LEU C CB  1 
ATOM 9042  C CG  . LEU C 1 469 ? 24.881  8.371   57.844  1.00 75.33  ? 463 LEU C CG  1 
ATOM 9043  C CD1 . LEU C 1 469 ? 24.972  7.848   59.261  1.00 78.60  ? 463 LEU C CD1 1 
ATOM 9044  C CD2 . LEU C 1 469 ? 23.563  9.085   57.610  1.00 71.35  ? 463 LEU C CD2 1 
ATOM 9045  N N   . HIS C 1 470 ? 28.254  11.550  57.814  1.00 70.15  ? 464 HIS C N   1 
ATOM 9046  C CA  . HIS C 1 470 ? 29.595  11.814  58.376  1.00 77.17  ? 464 HIS C CA  1 
ATOM 9047  C C   . HIS C 1 470 ? 29.535  12.960  59.369  1.00 104.06 ? 464 HIS C C   1 
ATOM 9048  O O   . HIS C 1 470 ? 30.118  12.844  60.445  1.00 127.53 ? 464 HIS C O   1 
ATOM 9049  C CB  . HIS C 1 470 ? 30.619  12.123  57.290  1.00 72.13  ? 464 HIS C CB  1 
ATOM 9050  C CG  . HIS C 1 470 ? 32.007  12.258  57.810  1.00 74.62  ? 464 HIS C CG  1 
ATOM 9051  N ND1 . HIS C 1 470 ? 32.592  13.477  58.064  1.00 85.53  ? 464 HIS C ND1 1 
ATOM 9052  C CD2 . HIS C 1 470 ? 32.918  11.338  58.122  1.00 76.67  ? 464 HIS C CD2 1 
ATOM 9053  C CE1 . HIS C 1 470 ? 33.821  13.283  58.512  1.00 86.52  ? 464 HIS C CE1 1 
ATOM 9054  N NE2 . HIS C 1 470 ? 34.037  11.992  58.555  1.00 83.47  ? 464 HIS C NE2 1 
ATOM 9055  N N   . GLU C 1 471 ? 28.782  14.006  59.061  1.00 123.85 ? 465 GLU C N   1 
ATOM 9056  C CA  . GLU C 1 471 ? 28.867  15.175  59.971  1.00 132.70 ? 465 GLU C CA  1 
ATOM 9057  C C   . GLU C 1 471 ? 28.376  14.784  61.366  1.00 126.89 ? 465 GLU C C   1 
ATOM 9058  O O   . GLU C 1 471 ? 29.006  15.207  62.348  1.00 119.90 ? 465 GLU C O   1 
ATOM 9059  C CB  . GLU C 1 471 ? 28.049  16.372  59.495  1.00 136.80 ? 465 GLU C CB  1 
ATOM 9060  C CG  . GLU C 1 471 ? 27.072  16.065  58.366  1.00 132.55 ? 465 GLU C CG  1 
ATOM 9061  C CD  . GLU C 1 471 ? 26.001  17.134  58.257  1.00 124.77 ? 465 GLU C CD  1 
ATOM 9062  O OE1 . GLU C 1 471 ? 25.468  17.524  59.315  1.00 121.19 ? 465 GLU C OE1 1 
ATOM 9063  O OE2 . GLU C 1 471 ? 25.708  17.581  57.131  1.00 121.79 ? 465 GLU C OE2 1 
ATOM 9064  N N   . LYS C 1 472 ? 27.300  14.011  61.443  1.00 115.35 ? 466 LYS C N   1 
ATOM 9065  C CA  . LYS C 1 472 ? 26.764  13.684  62.780  1.00 102.95 ? 466 LYS C CA  1 
ATOM 9066  C C   . LYS C 1 472 ? 27.827  12.882  63.529  1.00 99.88  ? 466 LYS C C   1 
ATOM 9067  O O   . LYS C 1 472 ? 28.031  13.151  64.725  1.00 100.64 ? 466 LYS C O   1 
ATOM 9068  C CB  . LYS C 1 472 ? 25.449  12.924  62.600  1.00 96.64  ? 466 LYS C CB  1 
ATOM 9069  C CG  . LYS C 1 472 ? 24.964  12.159  63.817  1.00 100.04 ? 466 LYS C CG  1 
ATOM 9070  C CD  . LYS C 1 472 ? 24.133  10.944  63.429  1.00 105.98 ? 466 LYS C CD  1 
ATOM 9071  C CE  . LYS C 1 472 ? 24.742  10.181  62.298  1.00 112.04 ? 466 LYS C CE  1 
ATOM 9072  N NZ  . LYS C 1 472 ? 25.115  8.826   62.710  1.00 117.37 ? 466 LYS C NZ  1 
ATOM 9073  N N   . THR C 1 473 ? 28.490  11.958  62.837  1.00 97.36  ? 467 THR C N   1 
ATOM 9074  C CA  . THR C 1 473 ? 29.490  11.083  63.475  1.00 93.74  ? 467 THR C CA  1 
ATOM 9075  C C   . THR C 1 473 ? 30.740  11.097  62.641  1.00 95.34  ? 467 THR C C   1 
ATOM 9076  O O   . THR C 1 473 ? 30.978  10.115  61.920  1.00 85.36  ? 467 THR C O   1 
ATOM 9077  C CB  . THR C 1 473 ? 28.900  9.689   63.611  1.00 86.26  ? 467 THR C CB  1 
ATOM 9078  O OG1 . THR C 1 473 ? 28.312  9.437   62.340  1.00 95.45  ? 467 THR C OG1 1 
ATOM 9079  C CG2 . THR C 1 473 ? 27.847  9.607   64.700  1.00 84.46  ? 467 THR C CG2 1 
ATOM 9080  N N   . PRO C 1 474 ? 31.544  12.172  62.667  1.00 97.41  ? 468 PRO C N   1 
ATOM 9081  C CA  . PRO C 1 474 ? 32.678  12.264  61.756  1.00 104.01 ? 468 PRO C CA  1 
ATOM 9082  C C   . PRO C 1 474 ? 34.047  11.666  62.033  1.00 101.27 ? 468 PRO C C   1 
ATOM 9083  O O   . PRO C 1 474 ? 34.705  12.127  62.974  1.00 121.74 ? 468 PRO C O   1 
ATOM 9084  C CB  . PRO C 1 474 ? 32.746  13.803  61.760  1.00 109.92 ? 468 PRO C CB  1 
ATOM 9085  C CG  . PRO C 1 474 ? 32.505  14.202  63.188  1.00 100.76 ? 468 PRO C CG  1 
ATOM 9086  C CD  . PRO C 1 474 ? 31.382  13.282  63.585  1.00 91.86  ? 468 PRO C CD  1 
ATOM 9087  N N   . VAL C 1 475 ? 34.474  10.669  61.256  1.00 93.00  ? 469 VAL C N   1 
ATOM 9088  C CA  . VAL C 1 475 ? 35.870  10.171  61.370  1.00 95.25  ? 469 VAL C CA  1 
ATOM 9089  C C   . VAL C 1 475 ? 36.994  11.013  60.747  1.00 98.34  ? 469 VAL C C   1 
ATOM 9090  O O   . VAL C 1 475 ? 38.033  11.151  61.414  1.00 100.18 ? 469 VAL C O   1 
ATOM 9091  C CB  . VAL C 1 475 ? 35.751  8.789   60.709  1.00 96.11  ? 469 VAL C CB  1 
ATOM 9092  C CG1 . VAL C 1 475 ? 34.852  7.875   61.528  1.00 106.95 ? 469 VAL C CG1 1 
ATOM 9093  C CG2 . VAL C 1 475 ? 35.224  8.884   59.284  1.00 82.77  ? 469 VAL C CG2 1 
ATOM 9094  N N   . SER C 1 476 ? 36.799  11.573  59.546  1.00 102.23 ? 470 SER C N   1 
ATOM 9095  C CA  . SER C 1 476 ? 37.959  12.181  58.827  1.00 104.22 ? 470 SER C CA  1 
ATOM 9096  C C   . SER C 1 476 ? 37.779  13.594  58.270  1.00 86.93  ? 470 SER C C   1 
ATOM 9097  O O   . SER C 1 476 ? 36.711  13.902  57.746  1.00 75.19  ? 470 SER C O   1 
ATOM 9098  C CB  . SER C 1 476 ? 38.429  11.267  57.720  1.00 103.46 ? 470 SER C CB  1 
ATOM 9099  O OG  . SER C 1 476 ? 39.702  11.663  57.229  1.00 92.69  ? 470 SER C OG  1 
ATOM 9100  N N   . ASP C 1 477 ? 38.834  14.391  58.338  1.00 82.19  ? 471 ASP C N   1 
ATOM 9101  C CA  . ASP C 1 477 ? 38.831  15.742  57.730  1.00 86.15  ? 471 ASP C CA  1 
ATOM 9102  C C   . ASP C 1 477 ? 38.669  15.649  56.217  1.00 74.18  ? 471 ASP C C   1 
ATOM 9103  O O   . ASP C 1 477 ? 37.990  16.504  55.645  1.00 67.91  ? 471 ASP C O   1 
ATOM 9104  C CB  . ASP C 1 477 ? 40.115  16.474  58.075  1.00 97.45  ? 471 ASP C CB  1 
ATOM 9105  C CG  . ASP C 1 477 ? 41.344  15.606  58.291  1.00 99.36  ? 471 ASP C CG  1 
ATOM 9106  O OD1 . ASP C 1 477 ? 41.316  14.778  59.222  1.00 99.84  ? 471 ASP C OD1 1 
ATOM 9107  O OD2 . ASP C 1 477 ? 42.319  15.776  57.531  1.00 97.66  ? 471 ASP C OD2 1 
ATOM 9108  N N   . ARG C 1 478 ? 39.321  14.682  55.588  1.00 75.46  ? 472 ARG C N   1 
ATOM 9109  C CA  . ARG C 1 478 ? 39.318  14.626  54.112  1.00 73.17  ? 472 ARG C CA  1 
ATOM 9110  C C   . ARG C 1 478 ? 37.913  14.421  53.573  1.00 63.58  ? 472 ARG C C   1 
ATOM 9111  O O   . ARG C 1 478 ? 37.571  15.044  52.568  1.00 66.79  ? 472 ARG C O   1 
ATOM 9112  C CB  . ARG C 1 478 ? 40.131  13.412  53.674  1.00 75.20  ? 472 ARG C CB  1 
ATOM 9113  C CG  . ARG C 1 478 ? 41.416  13.168  54.448  1.00 85.10  ? 472 ARG C CG  1 
ATOM 9114  C CD  . ARG C 1 478 ? 42.382  12.285  53.676  1.00 89.10  ? 472 ARG C CD  1 
ATOM 9115  N NE  . ARG C 1 478 ? 41.943  10.888  53.608  1.00 90.44  ? 472 ARG C NE  1 
ATOM 9116  C CZ  . ARG C 1 478 ? 42.480  9.965   52.822  1.00 92.07  ? 472 ARG C CZ  1 
ATOM 9117  N NH1 . ARG C 1 478 ? 43.319  10.312  51.864  1.00 92.68  ? 472 ARG C NH1 1 
ATOM 9118  N NH2 . ARG C 1 478 ? 42.173  8.696   52.992  1.00 85.66  ? 472 ARG C NH2 1 
ATOM 9119  N N   . VAL C 1 479 ? 37.146  13.561  54.214  1.00 66.27  ? 473 VAL C N   1 
ATOM 9120  C CA  . VAL C 1 479 ? 35.755  13.307  53.753  1.00 71.12  ? 473 VAL C CA  1 
ATOM 9121  C C   . VAL C 1 479 ? 34.966  14.609  53.895  1.00 66.70  ? 473 VAL C C   1 
ATOM 9122  O O   . VAL C 1 479 ? 34.176  14.917  52.989  1.00 64.23  ? 473 VAL C O   1 
ATOM 9123  C CB  . VAL C 1 479 ? 35.100  12.104  54.455  1.00 72.44  ? 473 VAL C CB  1 
ATOM 9124  C CG1 . VAL C 1 479 ? 35.749  11.771  55.786  1.00 74.95  ? 473 VAL C CG1 1 
ATOM 9125  C CG2 . VAL C 1 479 ? 33.591  12.247  54.577  1.00 69.84  ? 473 VAL C CG2 1 
ATOM 9126  N N   . THR C 1 480 ? 35.187  15.335  54.989  1.00 69.71  ? 474 THR C N   1 
ATOM 9127  C CA  . THR C 1 480 ? 34.470  16.605  55.218  1.00 72.57  ? 474 THR C CA  1 
ATOM 9128  C C   . THR C 1 480 ? 34.850  17.566  54.127  1.00 73.97  ? 474 THR C C   1 
ATOM 9129  O O   . THR C 1 480 ? 33.957  18.242  53.603  1.00 71.09  ? 474 THR C O   1 
ATOM 9130  C CB  . THR C 1 480 ? 34.815  17.151  56.600  1.00 70.69  ? 474 THR C CB  1 
ATOM 9131  O OG1 . THR C 1 480 ? 33.883  16.540  57.484  1.00 69.63  ? 474 THR C OG1 1 
ATOM 9132  C CG2 . THR C 1 480 ? 34.683  18.659  56.686  1.00 65.00  ? 474 THR C CG2 1 
ATOM 9133  N N   . LYS C 1 481 ? 36.125  17.591  53.752  1.00 71.22  ? 475 LYS C N   1 
ATOM 9134  C CA  . LYS C 1 481 ? 36.532  18.439  52.614  1.00 70.05  ? 475 LYS C CA  1 
ATOM 9135  C C   . LYS C 1 481 ? 35.658  18.026  51.442  1.00 69.23  ? 475 LYS C C   1 
ATOM 9136  O O   . LYS C 1 481 ? 34.805  18.809  51.021  1.00 62.96  ? 475 LYS C O   1 
ATOM 9137  C CB  . LYS C 1 481 ? 37.993  18.217  52.231  1.00 73.94  ? 475 LYS C CB  1 
ATOM 9138  C CG  . LYS C 1 481 ? 38.663  19.385  51.527  1.00 85.16  ? 475 LYS C CG  1 
ATOM 9139  C CD  . LYS C 1 481 ? 39.139  19.057  50.118  1.00 97.96  ? 475 LYS C CD  1 
ATOM 9140  C CE  . LYS C 1 481 ? 40.230  19.966  49.648  1.00 98.17  ? 475 LYS C CE  1 
ATOM 9141  N NZ  . LYS C 1 481 ? 39.758  20.934  48.656  1.00 92.98  ? 475 LYS C NZ  1 
ATOM 9142  N N   . CYS C 1 482 ? 35.880  16.819  50.942  1.00 75.02  ? 476 CYS C N   1 
ATOM 9143  C CA  . CYS C 1 482 ? 35.089  16.446  49.750  1.00 81.53  ? 476 CYS C CA  1 
ATOM 9144  C C   . CYS C 1 482 ? 33.620  16.795  49.996  1.00 79.56  ? 476 CYS C C   1 
ATOM 9145  O O   . CYS C 1 482 ? 32.963  17.270  49.061  1.00 83.10  ? 476 CYS C O   1 
ATOM 9146  C CB  . CYS C 1 482 ? 35.267  14.969  49.429  1.00 77.97  ? 476 CYS C CB  1 
ATOM 9147  S SG  . CYS C 1 482 ? 36.997  14.458  49.295  1.00 87.90  ? 476 CYS C SG  1 
ATOM 9148  N N   . CYS C 1 483 ? 33.116  16.506  51.185  1.00 70.03  ? 477 CYS C N   1 
ATOM 9149  C CA  . CYS C 1 483 ? 31.668  16.702  51.419  1.00 71.21  ? 477 CYS C CA  1 
ATOM 9150  C C   . CYS C 1 483 ? 31.236  18.176  51.299  1.00 74.44  ? 477 CYS C C   1 
ATOM 9151  O O   . CYS C 1 483 ? 30.163  18.406  50.720  1.00 73.27  ? 477 CYS C O   1 
ATOM 9152  C CB  . CYS C 1 483 ? 31.341  16.115  52.782  1.00 70.88  ? 477 CYS C CB  1 
ATOM 9153  S SG  . CYS C 1 483 ? 31.035  14.336  52.747  1.00 72.75  ? 477 CYS C SG  1 
ATOM 9154  N N   . THR C 1 484 ? 32.015  19.121  51.830  1.00 77.19  ? 478 THR C N   1 
ATOM 9155  C CA  . THR C 1 484 ? 31.676  20.569  51.786  1.00 78.55  ? 478 THR C CA  1 
ATOM 9156  C C   . THR C 1 484 ? 32.196  21.260  50.535  1.00 76.27  ? 478 THR C C   1 
ATOM 9157  O O   . THR C 1 484 ? 31.881  22.446  50.359  1.00 76.30  ? 478 THR C O   1 
ATOM 9158  C CB  . THR C 1 484 ? 32.171  21.212  53.073  1.00 76.38  ? 478 THR C CB  1 
ATOM 9159  O OG1 . THR C 1 484 ? 33.385  20.538  53.383  1.00 73.53  ? 478 THR C OG1 1 
ATOM 9160  C CG2 . THR C 1 484 ? 31.184  21.040  54.211  1.00 73.86  ? 478 THR C CG2 1 
ATOM 9161  N N   . GLU C 1 485 ? 32.978  20.576  49.711  1.00 79.41  ? 479 GLU C N   1 
ATOM 9162  C CA  . GLU C 1 485 ? 33.514  21.091  48.423  1.00 84.05  ? 479 GLU C CA  1 
ATOM 9163  C C   . GLU C 1 485 ? 32.370  21.151  47.414  1.00 84.79  ? 479 GLU C C   1 
ATOM 9164  O O   . GLU C 1 485 ? 31.347  20.493  47.653  1.00 84.83  ? 479 GLU C O   1 
ATOM 9165  C CB  . GLU C 1 485 ? 34.637  20.263  47.806  1.00 89.03  ? 479 GLU C CB  1 
ATOM 9166  C CG  . GLU C 1 485 ? 35.992  20.446  48.482  1.00 93.17  ? 479 GLU C CG  1 
ATOM 9167  C CD  . GLU C 1 485 ? 36.601  21.828  48.393  1.00 89.27  ? 479 GLU C CD  1 
ATOM 9168  O OE1 . GLU C 1 485 ? 36.314  22.538  47.410  1.00 94.16  ? 479 GLU C OE1 1 
ATOM 9169  O OE2 . GLU C 1 485 ? 37.367  22.184  49.311  1.00 75.38  ? 479 GLU C OE2 1 
ATOM 9170  N N   . SER C 1 486 ? 32.507  21.940  46.357  1.00 88.23  ? 480 SER C N   1 
ATOM 9171  C CA  . SER C 1 486 ? 31.350  22.137  45.456  1.00 90.06  ? 480 SER C CA  1 
ATOM 9172  C C   . SER C 1 486 ? 30.905  20.831  44.812  1.00 80.21  ? 480 SER C C   1 
ATOM 9173  O O   . SER C 1 486 ? 31.754  20.039  44.395  1.00 81.08  ? 480 SER C O   1 
ATOM 9174  C CB  . SER C 1 486 ? 31.689  23.111  44.372  1.00 95.58  ? 480 SER C CB  1 
ATOM 9175  O OG  . SER C 1 486 ? 31.121  22.704  43.136  1.00 103.86 ? 480 SER C OG  1 
ATOM 9176  N N   . LEU C 1 487 ? 29.596  20.668  44.719  1.00 80.08  ? 481 LEU C N   1 
ATOM 9177  C CA  . LEU C 1 487 ? 28.989  19.439  44.175  1.00 85.52  ? 481 LEU C CA  1 
ATOM 9178  C C   . LEU C 1 487 ? 29.700  18.936  42.930  1.00 82.60  ? 481 LEU C C   1 
ATOM 9179  O O   . LEU C 1 487 ? 29.854  17.715  42.789  1.00 89.60  ? 481 LEU C O   1 
ATOM 9180  C CB  . LEU C 1 487 ? 27.584  19.919  43.845  1.00 97.01  ? 481 LEU C CB  1 
ATOM 9181  C CG  . LEU C 1 487 ? 27.480  21.048  42.815  1.00 117.26 ? 481 LEU C CG  1 
ATOM 9182  C CD1 . LEU C 1 487 ? 26.429  20.756  41.759  1.00 126.45 ? 481 LEU C CD1 1 
ATOM 9183  C CD2 . LEU C 1 487 ? 27.268  22.422  43.422  1.00 109.58 ? 481 LEU C CD2 1 
ATOM 9184  N N   . VAL C 1 488 ? 30.114  19.833  42.057  1.00 77.90  ? 482 VAL C N   1 
ATOM 9185  C CA  . VAL C 1 488 ? 30.660  19.357  40.798  1.00 78.03  ? 482 VAL C CA  1 
ATOM 9186  C C   . VAL C 1 488 ? 31.988  18.657  41.059  1.00 83.35  ? 482 VAL C C   1 
ATOM 9187  O O   . VAL C 1 488 ? 32.324  17.730  40.330  1.00 107.92 ? 482 VAL C O   1 
ATOM 9188  C CB  . VAL C 1 488 ? 30.823  20.451  39.724  1.00 80.64  ? 482 VAL C CB  1 
ATOM 9189  C CG1 . VAL C 1 488 ? 29.521  21.219  39.509  1.00 80.11  ? 482 VAL C CG1 1 
ATOM 9190  C CG2 . VAL C 1 488 ? 31.978  21.403  40.026  1.00 82.89  ? 482 VAL C CG2 1 
ATOM 9191  N N   . ASN C 1 489 ? 32.731  19.098  42.084  1.00 83.26  ? 483 ASN C N   1 
ATOM 9192  C CA  . ASN C 1 489 ? 34.024  18.509  42.413  1.00 86.87  ? 483 ASN C CA  1 
ATOM 9193  C C   . ASN C 1 489 ? 33.908  17.541  43.590  1.00 84.83  ? 483 ASN C C   1 
ATOM 9194  O O   . ASN C 1 489 ? 34.918  17.178  44.201  1.00 74.76  ? 483 ASN C O   1 
ATOM 9195  C CB  . ASN C 1 489 ? 35.081  19.575  42.680  1.00 84.69  ? 483 ASN C CB  1 
ATOM 9196  C CG  . ASN C 1 489 ? 35.838  19.937  41.428  1.00 88.27  ? 483 ASN C CG  1 
ATOM 9197  O OD1 . ASN C 1 489 ? 35.433  19.573  40.315  1.00 81.36  ? 483 ASN C OD1 1 
ATOM 9198  N ND2 . ASN C 1 489 ? 36.942  20.649  41.599  1.00 96.30  ? 483 ASN C ND2 1 
ATOM 9199  N N   . ARG C 1 490 ? 32.681  17.086  43.873  1.00 78.92  ? 484 ARG C N   1 
ATOM 9200  C CA  . ARG C 1 490 ? 32.473  16.189  44.993  1.00 78.98  ? 484 ARG C CA  1 
ATOM 9201  C C   . ARG C 1 490 ? 33.087  14.846  44.624  1.00 82.21  ? 484 ARG C C   1 
ATOM 9202  O O   . ARG C 1 490 ? 34.153  14.494  45.126  1.00 98.40  ? 484 ARG C O   1 
ATOM 9203  C CB  . ARG C 1 490 ? 31.001  16.051  45.397  1.00 74.79  ? 484 ARG C CB  1 
ATOM 9204  C CG  . ARG C 1 490 ? 30.880  15.705  46.874  1.00 80.02  ? 484 ARG C CG  1 
ATOM 9205  C CD  . ARG C 1 490 ? 29.732  14.772  47.230  1.00 90.39  ? 484 ARG C CD  1 
ATOM 9206  N NE  . ARG C 1 490 ? 28.360  15.273  47.417  1.00 94.87  ? 484 ARG C NE  1 
ATOM 9207  C CZ  . ARG C 1 490 ? 27.864  15.917  48.485  1.00 84.40  ? 484 ARG C CZ  1 
ATOM 9208  N NH1 . ARG C 1 490 ? 28.662  16.631  49.275  1.00 75.62  ? 484 ARG C NH1 1 
ATOM 9209  N NH2 . ARG C 1 490 ? 26.551  15.889  48.706  1.00 72.46  ? 484 ARG C NH2 1 
ATOM 9210  N N   . ARG C 1 491 ? 32.441  14.160  43.679  1.00 72.59  ? 485 ARG C N   1 
ATOM 9211  C CA  . ARG C 1 491 ? 32.830  12.822  43.279  1.00 63.70  ? 485 ARG C CA  1 
ATOM 9212  C C   . ARG C 1 491 ? 34.329  12.774  42.939  1.00 72.38  ? 485 ARG C C   1 
ATOM 9213  O O   . ARG C 1 491 ? 35.030  11.901  43.447  1.00 78.48  ? 485 ARG C O   1 
ATOM 9214  C CB  . ARG C 1 491 ? 31.852  12.415  42.175  1.00 56.43  ? 485 ARG C CB  1 
ATOM 9215  C CG  . ARG C 1 491 ? 31.931  10.952  41.777  1.00 59.42  ? 485 ARG C CG  1 
ATOM 9216  C CD  . ARG C 1 491 ? 33.189  10.580  41.009  1.00 60.71  ? 485 ARG C CD  1 
ATOM 9217  N NE  . ARG C 1 491 ? 33.386  11.387  39.800  1.00 60.62  ? 485 ARG C NE  1 
ATOM 9218  C CZ  . ARG C 1 491 ? 34.517  11.434  39.102  1.00 62.82  ? 485 ARG C CZ  1 
ATOM 9219  N NH1 . ARG C 1 491 ? 35.604  10.775  39.502  1.00 56.52  ? 485 ARG C NH1 1 
ATOM 9220  N NH2 . ARG C 1 491 ? 34.542  12.158  37.995  1.00 66.02  ? 485 ARG C NH2 1 
ATOM 9221  N N   . PRO C 1 492 ? 34.896  13.672  42.089  1.00 69.73  ? 486 PRO C N   1 
ATOM 9222  C CA  . PRO C 1 492 ? 36.325  13.645  41.775  1.00 68.30  ? 486 PRO C CA  1 
ATOM 9223  C C   . PRO C 1 492 ? 37.227  13.872  42.980  1.00 77.65  ? 486 PRO C C   1 
ATOM 9224  O O   . PRO C 1 492 ? 38.384  13.459  42.975  1.00 82.13  ? 486 PRO C O   1 
ATOM 9225  C CB  . PRO C 1 492 ? 36.515  14.764  40.748  1.00 68.06  ? 486 PRO C CB  1 
ATOM 9226  C CG  . PRO C 1 492 ? 35.151  14.953  40.159  1.00 72.56  ? 486 PRO C CG  1 
ATOM 9227  C CD  . PRO C 1 492 ? 34.204  14.721  41.330  1.00 75.55  ? 486 PRO C CD  1 
ATOM 9228  N N   . CYS C 1 493 ? 36.712  14.571  43.994  1.00 83.54  ? 487 CYS C N   1 
ATOM 9229  C CA  . CYS C 1 493 ? 37.477  14.757  45.211  1.00 83.12  ? 487 CYS C CA  1 
ATOM 9230  C C   . CYS C 1 493 ? 37.521  13.463  46.030  1.00 85.01  ? 487 CYS C C   1 
ATOM 9231  O O   . CYS C 1 493 ? 38.489  13.260  46.763  1.00 98.16  ? 487 CYS C O   1 
ATOM 9232  C CB  . CYS C 1 493 ? 36.949  15.932  46.014  1.00 80.55  ? 487 CYS C CB  1 
ATOM 9233  S SG  . CYS C 1 493 ? 38.205  16.569  47.145  1.00 98.71  ? 487 CYS C SG  1 
ATOM 9234  N N   . PHE C 1 494 ? 36.494  12.596  45.887  1.00 74.73  ? 488 PHE C N   1 
ATOM 9235  C CA  . PHE C 1 494 ? 36.435  11.284  46.537  1.00 73.85  ? 488 PHE C CA  1 
ATOM 9236  C C   . PHE C 1 494 ? 37.374  10.284  45.856  1.00 74.52  ? 488 PHE C C   1 
ATOM 9237  O O   . PHE C 1 494 ? 38.181  9.628   46.512  1.00 69.79  ? 488 PHE C O   1 
ATOM 9238  C CB  . PHE C 1 494 ? 35.034  10.656  46.559  1.00 70.96  ? 488 PHE C CB  1 
ATOM 9239  C CG  . PHE C 1 494 ? 34.190  11.028  47.771  1.00 80.72  ? 488 PHE C CG  1 
ATOM 9240  C CD1 . PHE C 1 494 ? 34.332  10.340  48.970  1.00 78.73  ? 488 PHE C CD1 1 
ATOM 9241  C CD2 . PHE C 1 494 ? 33.275  12.083  47.726  1.00 89.96  ? 488 PHE C CD2 1 
ATOM 9242  C CE1 . PHE C 1 494 ? 33.577  10.692  50.080  1.00 81.36  ? 488 PHE C CE1 1 
ATOM 9243  C CE2 . PHE C 1 494 ? 32.520  12.430  48.842  1.00 81.21  ? 488 PHE C CE2 1 
ATOM 9244  C CZ  . PHE C 1 494 ? 32.665  11.728  50.011  1.00 80.97  ? 488 PHE C CZ  1 
ATOM 9245  N N   . SER C 1 495 ? 37.263  10.165  44.531  1.00 72.68  ? 489 SER C N   1 
ATOM 9246  C CA  . SER C 1 495 ? 38.101  9.264   43.759  1.00 69.96  ? 489 SER C CA  1 
ATOM 9247  C C   . SER C 1 495 ? 39.592  9.604   43.889  1.00 69.21  ? 489 SER C C   1 
ATOM 9248  O O   . SER C 1 495 ? 40.420  8.734   43.642  1.00 70.78  ? 489 SER C O   1 
ATOM 9249  C CB  . SER C 1 495 ? 37.656  9.262   42.316  1.00 76.31  ? 489 SER C CB  1 
ATOM 9250  O OG  . SER C 1 495 ? 36.272  8.955   42.197  1.00 73.34  ? 489 SER C OG  1 
ATOM 9251  N N   . ALA C 1 496 ? 39.932  10.851  44.263  1.00 70.60  ? 490 ALA C N   1 
ATOM 9252  C CA  . ALA C 1 496 ? 41.315  11.294  44.416  1.00 72.46  ? 490 ALA C CA  1 
ATOM 9253  C C   . ALA C 1 496 ? 41.949  10.746  45.698  1.00 70.99  ? 490 ALA C C   1 
ATOM 9254  O O   . ALA C 1 496 ? 43.168  10.576  45.747  1.00 69.71  ? 490 ALA C O   1 
ATOM 9255  C CB  . ALA C 1 496 ? 41.379  12.810  44.403  1.00 75.78  ? 490 ALA C CB  1 
ATOM 9256  N N   . LEU C 1 497 ? 41.124  10.488  46.726  1.00 64.99  ? 491 LEU C N   1 
ATOM 9257  C CA  . LEU C 1 497 ? 41.582  10.006  48.025  1.00 64.97  ? 491 LEU C CA  1 
ATOM 9258  C C   . LEU C 1 497 ? 42.567  8.852   47.874  1.00 64.36  ? 491 LEU C C   1 
ATOM 9259  O O   . LEU C 1 497 ? 42.308  7.911   47.133  1.00 63.76  ? 491 LEU C O   1 
ATOM 9260  C CB  . LEU C 1 497 ? 40.372  9.558   48.839  1.00 62.05  ? 491 LEU C CB  1 
ATOM 9261  C CG  . LEU C 1 497 ? 39.437  10.682  49.291  1.00 65.07  ? 491 LEU C CG  1 
ATOM 9262  C CD1 . LEU C 1 497 ? 38.170  10.178  49.963  1.00 66.47  ? 491 LEU C CD1 1 
ATOM 9263  C CD2 . LEU C 1 497 ? 40.191  11.600  50.227  1.00 70.33  ? 491 LEU C CD2 1 
ATOM 9264  N N   . GLU C 1 498 ? 43.688  8.927   48.596  1.00 67.62  ? 492 GLU C N   1 
ATOM 9265  C CA  . GLU C 1 498 ? 44.666  7.852   48.588  1.00 80.69  ? 492 GLU C CA  1 
ATOM 9266  C C   . GLU C 1 498 ? 44.506  7.033   49.869  1.00 87.55  ? 492 GLU C C   1 
ATOM 9267  O O   . GLU C 1 498 ? 43.660  7.344   50.707  1.00 93.26  ? 492 GLU C O   1 
ATOM 9268  C CB  . GLU C 1 498 ? 46.077  8.414   48.386  1.00 87.39  ? 492 GLU C CB  1 
ATOM 9269  C CG  . GLU C 1 498 ? 46.350  8.922   46.970  1.00 99.38  ? 492 GLU C CG  1 
ATOM 9270  C CD  . GLU C 1 498 ? 46.519  7.854   45.899  1.00 115.12 ? 492 GLU C CD  1 
ATOM 9271  O OE1 . GLU C 1 498 ? 46.293  6.667   46.213  1.00 127.88 ? 492 GLU C OE1 1 
ATOM 9272  O OE2 . GLU C 1 498 ? 46.892  8.199   44.752  1.00 121.88 ? 492 GLU C OE2 1 
ATOM 9273  N N   . VAL C 1 499 ? 45.300  5.961   49.985  1.00 83.31  ? 493 VAL C N   1 
ATOM 9274  C CA  . VAL C 1 499 ? 45.369  5.153   51.194  1.00 78.39  ? 493 VAL C CA  1 
ATOM 9275  C C   . VAL C 1 499 ? 45.763  6.054   52.372  1.00 85.18  ? 493 VAL C C   1 
ATOM 9276  O O   . VAL C 1 499 ? 46.719  6.822   52.263  1.00 103.86 ? 493 VAL C O   1 
ATOM 9277  C CB  . VAL C 1 499 ? 46.362  3.993   50.964  1.00 80.34  ? 493 VAL C CB  1 
ATOM 9278  C CG1 . VAL C 1 499 ? 45.885  3.046   49.866  1.00 82.42  ? 493 VAL C CG1 1 
ATOM 9279  C CG2 . VAL C 1 499 ? 47.783  4.463   50.647  1.00 78.54  ? 493 VAL C CG2 1 
ATOM 9280  N N   . ASP C 1 500 ? 45.023  5.974   53.492  1.00 77.71  ? 494 ASP C N   1 
ATOM 9281  C CA  . ASP C 1 500 ? 45.154  6.908   54.610  1.00 82.27  ? 494 ASP C CA  1 
ATOM 9282  C C   . ASP C 1 500 ? 46.351  6.598   55.517  1.00 88.31  ? 494 ASP C C   1 
ATOM 9283  O O   . ASP C 1 500 ? 46.290  5.661   56.309  1.00 88.92  ? 494 ASP C O   1 
ATOM 9284  C CB  . ASP C 1 500 ? 43.906  6.919   55.481  1.00 88.43  ? 494 ASP C CB  1 
ATOM 9285  C CG  . ASP C 1 500 ? 43.957  7.808   56.722  1.00 100.44 ? 494 ASP C CG  1 
ATOM 9286  O OD1 . ASP C 1 500 ? 44.708  7.465   57.667  1.00 92.30  ? 494 ASP C OD1 1 
ATOM 9287  O OD2 . ASP C 1 500 ? 43.241  8.844   56.744  1.00 111.53 ? 494 ASP C OD2 1 
ATOM 9288  N N   . GLU C 1 501 ? 47.365  7.483   55.510  1.00 96.80  ? 495 GLU C N   1 
ATOM 9289  C CA  . GLU C 1 501 ? 48.656  7.235   56.147  1.00 97.70  ? 495 GLU C CA  1 
ATOM 9290  C C   . GLU C 1 501 ? 48.698  7.692   57.613  1.00 92.79  ? 495 GLU C C   1 
ATOM 9291  O O   . GLU C 1 501 ? 49.781  7.760   58.194  1.00 84.57  ? 495 GLU C O   1 
ATOM 9292  C CB  . GLU C 1 501 ? 49.767  7.943   55.364  1.00 103.79 ? 495 GLU C CB  1 
ATOM 9293  C CG  . GLU C 1 501 ? 50.047  7.364   53.978  1.00 119.87 ? 495 GLU C CG  1 
ATOM 9294  C CD  . GLU C 1 501 ? 50.857  6.073   53.932  1.00 128.97 ? 495 GLU C CD  1 
ATOM 9295  O OE1 . GLU C 1 501 ? 50.866  5.343   54.944  1.00 128.24 ? 495 GLU C OE1 1 
ATOM 9296  O OE2 . GLU C 1 501 ? 51.507  5.801   52.893  1.00 127.86 ? 495 GLU C OE2 1 
ATOM 9297  N N   . THR C 1 502 ? 47.542  7.987   58.229  1.00 87.52  ? 496 THR C N   1 
ATOM 9298  C CA  . THR C 1 502 ? 47.514  8.413   59.622  1.00 86.56  ? 496 THR C CA  1 
ATOM 9299  C C   . THR C 1 502 ? 46.785  7.375   60.474  1.00 93.60  ? 496 THR C C   1 
ATOM 9300  O O   . THR C 1 502 ? 46.433  7.657   61.617  1.00 102.36 ? 496 THR C O   1 
ATOM 9301  C CB  . THR C 1 502 ? 46.877  9.801   59.751  1.00 85.04  ? 496 THR C CB  1 
ATOM 9302  O OG1 . THR C 1 502 ? 45.540  9.755   59.260  1.00 79.93  ? 496 THR C OG1 1 
ATOM 9303  C CG2 . THR C 1 502 ? 47.658  10.862  58.997  1.00 86.90  ? 496 THR C CG2 1 
ATOM 9304  N N   . TYR C 1 503 ? 46.602  6.161   59.936  1.00 95.86  ? 497 TYR C N   1 
ATOM 9305  C CA  . TYR C 1 503 ? 45.747  5.164   60.564  1.00 90.56  ? 497 TYR C CA  1 
ATOM 9306  C C   . TYR C 1 503 ? 46.600  4.152   61.322  1.00 82.26  ? 497 TYR C C   1 
ATOM 9307  O O   . TYR C 1 503 ? 47.506  3.554   60.749  1.00 84.37  ? 497 TYR C O   1 
ATOM 9308  C CB  . TYR C 1 503 ? 44.869  4.430   59.545  1.00 86.44  ? 497 TYR C CB  1 
ATOM 9309  C CG  . TYR C 1 503 ? 43.913  3.441   60.201  1.00 92.13  ? 497 TYR C CG  1 
ATOM 9310  C CD1 . TYR C 1 503 ? 42.838  3.891   60.963  1.00 98.69  ? 497 TYR C CD1 1 
ATOM 9311  C CD2 . TYR C 1 503 ? 44.087  2.066   60.076  1.00 92.20  ? 497 TYR C CD2 1 
ATOM 9312  C CE1 . TYR C 1 503 ? 41.965  3.009   61.580  1.00 100.00 ? 497 TYR C CE1 1 
ATOM 9313  C CE2 . TYR C 1 503 ? 43.221  1.171   60.690  1.00 95.99  ? 497 TYR C CE2 1 
ATOM 9314  C CZ  . TYR C 1 503 ? 42.156  1.644   61.441  1.00 104.22 ? 497 TYR C CZ  1 
ATOM 9315  O OH  . TYR C 1 503 ? 41.286  0.782   62.051  1.00 108.12 ? 497 TYR C OH  1 
ATOM 9316  N N   . VAL C 1 504 ? 46.266  3.938   62.599  1.00 77.92  ? 498 VAL C N   1 
ATOM 9317  C CA  . VAL C 1 504 ? 46.962  2.957   63.414  1.00 82.68  ? 498 VAL C CA  1 
ATOM 9318  C C   . VAL C 1 504 ? 46.261  1.606   63.230  1.00 85.88  ? 498 VAL C C   1 
ATOM 9319  O O   . VAL C 1 504 ? 45.115  1.449   63.664  1.00 79.99  ? 498 VAL C O   1 
ATOM 9320  C CB  . VAL C 1 504 ? 47.038  3.367   64.901  1.00 81.80  ? 498 VAL C CB  1 
ATOM 9321  C CG1 . VAL C 1 504 ? 48.362  2.918   65.519  1.00 84.87  ? 498 VAL C CG1 1 
ATOM 9322  C CG2 . VAL C 1 504 ? 46.833  4.868   65.123  1.00 70.76  ? 498 VAL C CG2 1 
ATOM 9323  N N   . PRO C 1 505 ? 46.914  0.595   62.610  1.00 88.03  ? 499 PRO C N   1 
ATOM 9324  C CA  . PRO C 1 505 ? 46.308  -0.715  62.452  1.00 84.72  ? 499 PRO C CA  1 
ATOM 9325  C C   . PRO C 1 505 ? 45.700  -1.306  63.704  1.00 84.20  ? 499 PRO C C   1 
ATOM 9326  O O   . PRO C 1 505 ? 46.317  -1.224  64.771  1.00 89.08  ? 499 PRO C O   1 
ATOM 9327  C CB  . PRO C 1 505 ? 47.504  -1.522  61.972  1.00 86.90  ? 499 PRO C CB  1 
ATOM 9328  C CG  . PRO C 1 505 ? 48.254  -0.562  61.101  1.00 86.85  ? 499 PRO C CG  1 
ATOM 9329  C CD  . PRO C 1 505 ? 48.246  0.657   61.989  1.00 87.22  ? 499 PRO C CD  1 
ATOM 9330  N N   . LYS C 1 506 ? 44.514  -1.890  63.576  1.00 86.08  ? 500 LYS C N   1 
ATOM 9331  C CA  . LYS C 1 506 ? 43.776  -2.505  64.710  1.00 82.98  ? 500 LYS C CA  1 
ATOM 9332  C C   . LYS C 1 506 ? 44.434  -3.790  65.223  1.00 77.18  ? 500 LYS C C   1 
ATOM 9333  O O   . LYS C 1 506 ? 45.108  -4.448  64.434  1.00 70.80  ? 500 LYS C O   1 
ATOM 9334  C CB  . LYS C 1 506 ? 42.301  -2.691  64.330  1.00 83.71  ? 500 LYS C CB  1 
ATOM 9335  C CG  . LYS C 1 506 ? 41.837  -4.080  63.947  1.00 79.86  ? 500 LYS C CG  1 
ATOM 9336  C CD  . LYS C 1 506 ? 40.321  -4.081  63.822  1.00 77.56  ? 500 LYS C CD  1 
ATOM 9337  C CE  . LYS C 1 506 ? 39.756  -2.769  64.261  1.00 75.41  ? 500 LYS C CE  1 
ATOM 9338  N NZ  . LYS C 1 506 ? 38.402  -2.909  64.799  1.00 76.98  ? 500 LYS C NZ  1 
ATOM 9339  N N   . GLU C 1 507 ? 44.283  -4.079  66.509  1.00 78.68  ? 501 GLU C N   1 
ATOM 9340  C CA  . GLU C 1 507 ? 44.822  -5.297  67.180  1.00 90.42  ? 501 GLU C CA  1 
ATOM 9341  C C   . GLU C 1 507 ? 44.013  -6.540  66.770  1.00 85.19  ? 501 GLU C C   1 
ATOM 9342  O O   . GLU C 1 507 ? 42.885  -6.350  66.298  1.00 87.68  ? 501 GLU C O   1 
ATOM 9343  C CB  . GLU C 1 507 ? 44.996  -5.072  68.679  1.00 100.79 ? 501 GLU C CB  1 
ATOM 9344  C CG  . GLU C 1 507 ? 46.403  -5.426  69.150  1.00 111.04 ? 501 GLU C CG  1 
ATOM 9345  C CD  . GLU C 1 507 ? 47.285  -5.926  68.019  1.00 119.03 ? 501 GLU C CD  1 
ATOM 9346  O OE1 . GLU C 1 507 ? 48.017  -5.100  67.437  1.00 127.21 ? 501 GLU C OE1 1 
ATOM 9347  O OE2 . GLU C 1 507 ? 47.240  -7.137  67.714  1.00 119.67 ? 501 GLU C OE2 1 
ATOM 9348  N N   . PHE C 1 508 ? 44.533  -7.755  66.959  1.00 78.50  ? 502 PHE C N   1 
ATOM 9349  C CA  . PHE C 1 508 ? 43.937  -8.977  66.347  1.00 82.68  ? 502 PHE C CA  1 
ATOM 9350  C C   . PHE C 1 508 ? 42.500  -9.294  66.756  1.00 87.10  ? 502 PHE C C   1 
ATOM 9351  O O   . PHE C 1 508 ? 41.783  -9.730  65.849  1.00 112.21 ? 502 PHE C O   1 
ATOM 9352  C CB  . PHE C 1 508 ? 44.783  -10.210 66.659  1.00 79.17  ? 502 PHE C CB  1 
ATOM 9353  C CG  . PHE C 1 508 ? 44.411  -11.415 65.811  1.00 83.86  ? 502 PHE C CG  1 
ATOM 9354  C CD1 . PHE C 1 508 ? 44.526  -11.371 64.429  1.00 88.02  ? 502 PHE C CD1 1 
ATOM 9355  C CD2 . PHE C 1 508 ? 43.934  -12.578 66.395  1.00 88.91  ? 502 PHE C CD2 1 
ATOM 9356  C CE1 . PHE C 1 508 ? 44.182  -12.465 63.656  1.00 85.97  ? 502 PHE C CE1 1 
ATOM 9357  C CE2 . PHE C 1 508 ? 43.590  -13.668 65.616  1.00 93.37  ? 502 PHE C CE2 1 
ATOM 9358  C CZ  . PHE C 1 508 ? 43.710  -13.607 64.251  1.00 89.70  ? 502 PHE C CZ  1 
ATOM 9359  N N   . ASN C 1 509 ? 42.061  -9.145  68.003  1.00 78.77  ? 503 ASN C N   1 
ATOM 9360  C CA  . ASN C 1 509 ? 40.591  -9.351  68.170  1.00 77.98  ? 503 ASN C CA  1 
ATOM 9361  C C   . ASN C 1 509 ? 40.150  -10.688 67.579  1.00 78.75  ? 503 ASN C C   1 
ATOM 9362  O O   . ASN C 1 509 ? 39.273  -10.659 66.705  1.00 73.64  ? 503 ASN C O   1 
ATOM 9363  C CB  . ASN C 1 509 ? 39.735  -8.175  67.731  1.00 76.14  ? 503 ASN C CB  1 
ATOM 9364  C CG  . ASN C 1 509 ? 38.537  -8.035  68.640  1.00 77.84  ? 503 ASN C CG  1 
ATOM 9365  O OD1 . ASN C 1 509 ? 38.114  -9.018  69.258  1.00 79.52  ? 503 ASN C OD1 1 
ATOM 9366  N ND2 . ASN C 1 509 ? 37.986  -6.835  68.747  1.00 77.37  ? 503 ASN C ND2 1 
ATOM 9367  N N   . ALA C 1 510 ? 40.715  -11.813 67.981  1.00 74.15  ? 504 ALA C N   1 
ATOM 9368  C CA  . ALA C 1 510 ? 40.568  -13.131 67.330  1.00 71.05  ? 504 ALA C CA  1 
ATOM 9369  C C   . ALA C 1 510 ? 39.114  -13.583 67.274  1.00 66.03  ? 504 ALA C C   1 
ATOM 9370  O O   . ALA C 1 510 ? 38.753  -14.186 66.259  1.00 67.36  ? 504 ALA C O   1 
ATOM 9371  C CB  . ALA C 1 510 ? 41.334  -14.092 68.170  1.00 78.75  ? 504 ALA C CB  1 
ATOM 9372  N N   . GLU C 1 511 ? 38.294  -13.322 68.265  1.00 63.06  ? 505 GLU C N   1 
ATOM 9373  C CA  . GLU C 1 511 ? 36.923  -13.862 68.210  1.00 71.12  ? 505 GLU C CA  1 
ATOM 9374  C C   . GLU C 1 511 ? 36.286  -13.279 66.948  1.00 77.11  ? 505 GLU C C   1 
ATOM 9375  O O   . GLU C 1 511 ? 35.524  -14.010 66.305  1.00 84.05  ? 505 GLU C O   1 
ATOM 9376  C CB  . GLU C 1 511 ? 36.085  -13.408 69.397  1.00 76.11  ? 505 GLU C CB  1 
ATOM 9377  C CG  . GLU C 1 511 ? 34.608  -13.201 69.076  1.00 83.87  ? 505 GLU C CG  1 
ATOM 9378  C CD  . GLU C 1 511 ? 33.773  -14.467 68.991  1.00 96.56  ? 505 GLU C CD  1 
ATOM 9379  O OE1 . GLU C 1 511 ? 34.093  -15.441 69.703  1.00 101.29 ? 505 GLU C OE1 1 
ATOM 9380  O OE2 . GLU C 1 511 ? 32.798  -14.476 68.211  1.00 91.09  ? 505 GLU C OE2 1 
ATOM 9381  N N   . THR C 1 512 ? 36.548  -12.025 66.602  1.00 76.95  ? 506 THR C N   1 
ATOM 9382  C CA  . THR C 1 512 ? 35.886  -11.445 65.429  1.00 71.97  ? 506 THR C CA  1 
ATOM 9383  C C   . THR C 1 512 ? 36.312  -12.266 64.243  1.00 70.82  ? 506 THR C C   1 
ATOM 9384  O O   . THR C 1 512 ? 35.478  -12.477 63.355  1.00 71.12  ? 506 THR C O   1 
ATOM 9385  C CB  . THR C 1 512 ? 36.330  -9.997  65.291  1.00 71.89  ? 506 THR C CB  1 
ATOM 9386  O OG1 . THR C 1 512 ? 37.723  -10.076 65.024  1.00 82.49  ? 506 THR C OG1 1 
ATOM 9387  C CG2 . THR C 1 512 ? 36.076  -9.195  66.552  1.00 70.46  ? 506 THR C CG2 1 
ATOM 9388  N N   . PHE C 1 513 ? 37.570  -12.664 64.175  1.00 70.37  ? 507 PHE C N   1 
ATOM 9389  C CA  . PHE C 1 513 ? 38.054  -13.581 63.104  1.00 71.66  ? 507 PHE C CA  1 
ATOM 9390  C C   . PHE C 1 513 ? 37.359  -14.960 63.198  1.00 71.49  ? 507 PHE C C   1 
ATOM 9391  O O   . PHE C 1 513 ? 37.116  -15.545 62.140  1.00 72.67  ? 507 PHE C O   1 
ATOM 9392  C CB  . PHE C 1 513 ? 39.577  -13.473 63.074  1.00 71.42  ? 507 PHE C CB  1 
ATOM 9393  C CG  . PHE C 1 513 ? 39.975  -12.090 62.583  1.00 76.06  ? 507 PHE C CG  1 
ATOM 9394  C CD1 . PHE C 1 513 ? 39.347  -11.527 61.480  1.00 77.61  ? 507 PHE C CD1 1 
ATOM 9395  C CD2 . PHE C 1 513 ? 40.936  -11.339 63.245  1.00 77.75  ? 507 PHE C CD2 1 
ATOM 9396  C CE1 . PHE C 1 513 ? 39.690  -10.263 61.035  1.00 71.23  ? 507 PHE C CE1 1 
ATOM 9397  C CE2 . PHE C 1 513 ? 41.276  -10.076 62.793  1.00 78.85  ? 507 PHE C CE2 1 
ATOM 9398  C CZ  . PHE C 1 513 ? 40.652  -9.542  61.692  1.00 74.79  ? 507 PHE C CZ  1 
ATOM 9399  N N   . THR C 1 514 ? 37.122  -15.502 64.390  1.00 71.39  ? 508 THR C N   1 
ATOM 9400  C CA  . THR C 1 514 ? 36.550  -16.863 64.504  1.00 74.31  ? 508 THR C CA  1 
ATOM 9401  C C   . THR C 1 514 ? 35.157  -16.935 63.906  1.00 73.40  ? 508 THR C C   1 
ATOM 9402  O O   . THR C 1 514 ? 34.361  -16.011 64.139  1.00 64.90  ? 508 THR C O   1 
ATOM 9403  C CB  . THR C 1 514 ? 36.516  -17.252 65.979  1.00 73.38  ? 508 THR C CB  1 
ATOM 9404  O OG1 . THR C 1 514 ? 37.871  -17.152 66.400  1.00 77.74  ? 508 THR C OG1 1 
ATOM 9405  C CG2 . THR C 1 514 ? 36.005  -18.661 66.210  1.00 67.45  ? 508 THR C CG2 1 
ATOM 9406  N N   . PHE C 1 515 ? 34.848  -18.037 63.216  1.00 73.11  ? 509 PHE C N   1 
ATOM 9407  C CA  . PHE C 1 515 ? 33.550  -18.208 62.519  1.00 78.63  ? 509 PHE C CA  1 
ATOM 9408  C C   . PHE C 1 515 ? 32.856  -19.475 62.991  1.00 83.34  ? 509 PHE C C   1 
ATOM 9409  O O   . PHE C 1 515 ? 33.526  -20.303 63.635  1.00 79.46  ? 509 PHE C O   1 
ATOM 9410  C CB  . PHE C 1 515 ? 33.906  -18.297 61.039  1.00 79.75  ? 509 PHE C CB  1 
ATOM 9411  C CG  . PHE C 1 515 ? 33.920  -16.943 60.353  1.00 81.32  ? 509 PHE C CG  1 
ATOM 9412  C CD1 . PHE C 1 515 ? 32.738  -16.350 59.931  1.00 85.54  ? 509 PHE C CD1 1 
ATOM 9413  C CD2 . PHE C 1 515 ? 35.110  -16.259 60.158  1.00 75.87  ? 509 PHE C CD2 1 
ATOM 9414  C CE1 . PHE C 1 515 ? 32.750  -15.111 59.319  1.00 87.15  ? 509 PHE C CE1 1 
ATOM 9415  C CE2 . PHE C 1 515 ? 35.116  -15.016 59.553  1.00 78.61  ? 509 PHE C CE2 1 
ATOM 9416  C CZ  . PHE C 1 515 ? 33.937  -14.449 59.131  1.00 88.58  ? 509 PHE C CZ  1 
ATOM 9417  N N   . HIS C 1 516 ? 31.557  -19.632 62.686  1.00 78.38  ? 510 HIS C N   1 
ATOM 9418  C CA  . HIS C 1 516 ? 30.835  -20.808 63.236  1.00 73.23  ? 510 HIS C CA  1 
ATOM 9419  C C   . HIS C 1 516 ? 29.934  -21.556 62.250  1.00 64.80  ? 510 HIS C C   1 
ATOM 9420  O O   . HIS C 1 516 ? 29.715  -21.065 61.146  1.00 58.73  ? 510 HIS C O   1 
ATOM 9421  C CB  . HIS C 1 516 ? 30.092  -20.363 64.498  1.00 72.69  ? 510 HIS C CB  1 
ATOM 9422  C CG  . HIS C 1 516 ? 30.984  -20.103 65.665  1.00 65.38  ? 510 HIS C CG  1 
ATOM 9423  N ND1 . HIS C 1 516 ? 31.741  -18.961 65.783  1.00 60.24  ? 510 HIS C ND1 1 
ATOM 9424  C CD2 . HIS C 1 516 ? 31.239  -20.827 66.757  1.00 64.76  ? 510 HIS C CD2 1 
ATOM 9425  C CE1 . HIS C 1 516 ? 32.426  -19.007 66.913  1.00 63.88  ? 510 HIS C CE1 1 
ATOM 9426  N NE2 . HIS C 1 516 ? 32.136  -20.131 67.520  1.00 60.60  ? 510 HIS C NE2 1 
ATOM 9427  N N   . ALA C 1 517 ? 29.389  -22.689 62.674  1.00 67.39  ? 511 ALA C N   1 
ATOM 9428  C CA  . ALA C 1 517 ? 28.570  -23.621 61.871  1.00 76.64  ? 511 ALA C CA  1 
ATOM 9429  C C   . ALA C 1 517 ? 27.324  -22.860 61.449  1.00 78.80  ? 511 ALA C C   1 
ATOM 9430  O O   . ALA C 1 517 ? 26.684  -23.241 60.458  1.00 72.85  ? 511 ALA C O   1 
ATOM 9431  C CB  . ALA C 1 517 ? 28.235  -24.821 62.687  1.00 87.95  ? 511 ALA C CB  1 
ATOM 9432  N N   . ASP C 1 518 ? 26.977  -21.828 62.192  1.00 82.15  ? 512 ASP C N   1 
ATOM 9433  C CA  . ASP C 1 518 ? 25.741  -21.056 61.950  1.00 87.42  ? 512 ASP C CA  1 
ATOM 9434  C C   . ASP C 1 518 ? 25.860  -20.506 60.532  1.00 94.55  ? 512 ASP C C   1 
ATOM 9435  O O   . ASP C 1 518 ? 24.841  -20.519 59.825  1.00 97.07  ? 512 ASP C O   1 
ATOM 9436  C CB  . ASP C 1 518 ? 25.609  -19.936 62.962  1.00 97.39  ? 512 ASP C CB  1 
ATOM 9437  C CG  . ASP C 1 518 ? 26.574  -18.772 62.794  1.00 109.10 ? 512 ASP C CG  1 
ATOM 9438  O OD1 . ASP C 1 518 ? 27.746  -19.029 62.464  1.00 96.92  ? 512 ASP C OD1 1 
ATOM 9439  O OD2 . ASP C 1 518 ? 26.143  -17.616 62.991  1.00 122.61 ? 512 ASP C OD2 1 
ATOM 9440  N N   . ILE C 1 519 ? 27.039  -20.109 60.087  1.00 92.77  ? 513 ILE C N   1 
ATOM 9441  C CA  . ILE C 1 519 ? 27.164  -19.436 58.766  1.00 88.01  ? 513 ILE C CA  1 
ATOM 9442  C C   . ILE C 1 519 ? 26.670  -20.398 57.679  1.00 86.00  ? 513 ILE C C   1 
ATOM 9443  O O   . ILE C 1 519 ? 26.050  -19.897 56.734  1.00 102.44 ? 513 ILE C O   1 
ATOM 9444  C CB  . ILE C 1 519 ? 28.618  -18.998 58.515  1.00 95.26  ? 513 ILE C CB  1 
ATOM 9445  C CG1 . ILE C 1 519 ? 28.694  -17.840 57.523  1.00 96.00  ? 513 ILE C CG1 1 
ATOM 9446  C CG2 . ILE C 1 519 ? 29.504  -20.167 58.082  1.00 89.42  ? 513 ILE C CG2 1 
ATOM 9447  C CD1 . ILE C 1 519 ? 30.106  -17.356 57.259  1.00 99.05  ? 513 ILE C CD1 1 
ATOM 9448  N N   . CYS C 1 520 ? 26.938  -21.694 57.746  1.00 80.31  ? 514 CYS C N   1 
ATOM 9449  C CA  . CYS C 1 520 ? 26.465  -22.542 56.623  1.00 79.65  ? 514 CYS C CA  1 
ATOM 9450  C C   . CYS C 1 520 ? 24.918  -22.489 56.549  1.00 75.94  ? 514 CYS C C   1 
ATOM 9451  O O   . CYS C 1 520 ? 24.392  -22.482 55.423  1.00 70.28  ? 514 CYS C O   1 
ATOM 9452  C CB  . CYS C 1 520 ? 27.032  -23.954 56.750  1.00 79.27  ? 514 CYS C CB  1 
ATOM 9453  S SG  . CYS C 1 520 ? 28.845  -24.057 56.766  1.00 83.81  ? 514 CYS C SG  1 
ATOM 9454  N N   . THR C 1 521 ? 24.191  -22.391 57.655  1.00 73.06  ? 515 THR C N   1 
ATOM 9455  C CA  . THR C 1 521 ? 22.717  -22.449 57.549  1.00 78.04  ? 515 THR C CA  1 
ATOM 9456  C C   . THR C 1 521 ? 22.130  -21.066 57.401  1.00 80.31  ? 515 THR C C   1 
ATOM 9457  O O   . THR C 1 521 ? 20.912  -20.962 57.179  1.00 79.76  ? 515 THR C O   1 
ATOM 9458  C CB  . THR C 1 521 ? 22.163  -23.144 58.785  1.00 85.91  ? 515 THR C CB  1 
ATOM 9459  O OG1 . THR C 1 521 ? 20.756  -23.160 58.579  1.00 96.70  ? 515 THR C OG1 1 
ATOM 9460  C CG2 . THR C 1 521 ? 22.469  -22.401 60.071  1.00 89.12  ? 515 THR C CG2 1 
ATOM 9461  N N   . LEU C 1 522 ? 22.951  -20.033 57.509  1.00 80.23  ? 516 LEU C N   1 
ATOM 9462  C CA  . LEU C 1 522 ? 22.483  -18.625 57.438  1.00 79.22  ? 516 LEU C CA  1 
ATOM 9463  C C   . LEU C 1 522 ? 22.034  -18.284 56.016  1.00 85.88  ? 516 LEU C C   1 
ATOM 9464  O O   . LEU C 1 522 ? 22.539  -18.919 55.078  1.00 100.50 ? 516 LEU C O   1 
ATOM 9465  C CB  . LEU C 1 522 ? 23.555  -17.650 57.925  1.00 74.39  ? 516 LEU C CB  1 
ATOM 9466  C CG  . LEU C 1 522 ? 23.746  -17.537 59.437  1.00 70.63  ? 516 LEU C CG  1 
ATOM 9467  C CD1 . LEU C 1 522 ? 24.677  -16.380 59.725  1.00 66.28  ? 516 LEU C CD1 1 
ATOM 9468  C CD2 . LEU C 1 522 ? 22.412  -17.339 60.125  1.00 76.21  ? 516 LEU C CD2 1 
ATOM 9469  N N   . SER C 1 523 ? 21.103  -17.344 55.876  1.00 81.50  ? 517 SER C N   1 
ATOM 9470  C CA  . SER C 1 523 ? 20.633  -16.871 54.549  1.00 84.11  ? 517 SER C CA  1 
ATOM 9471  C C   . SER C 1 523 ? 21.788  -16.156 53.857  1.00 87.48  ? 517 SER C C   1 
ATOM 9472  O O   . SER C 1 523 ? 22.602  -15.546 54.555  1.00 80.89  ? 517 SER C O   1 
ATOM 9473  C CB  . SER C 1 523 ? 19.459  -15.965 54.667  1.00 85.87  ? 517 SER C CB  1 
ATOM 9474  O OG  . SER C 1 523 ? 19.858  -14.604 54.597  1.00 89.86  ? 517 SER C OG  1 
ATOM 9475  N N   . GLU C 1 524 ? 21.837  -16.188 52.534  1.00 94.93  ? 518 GLU C N   1 
ATOM 9476  C CA  . GLU C 1 524 ? 23.033  -15.695 51.817  1.00 96.18  ? 518 GLU C CA  1 
ATOM 9477  C C   . GLU C 1 524 ? 23.261  -14.227 52.108  1.00 79.97  ? 518 GLU C C   1 
ATOM 9478  O O   . GLU C 1 524 ? 24.417  -13.863 52.340  1.00 67.77  ? 518 GLU C O   1 
ATOM 9479  C CB  . GLU C 1 524 ? 22.767  -15.798 50.318  1.00 109.36 ? 518 GLU C CB  1 
ATOM 9480  C CG  . GLU C 1 524 ? 23.282  -14.613 49.504  1.00 126.91 ? 518 GLU C CG  1 
ATOM 9481  C CD  . GLU C 1 524 ? 22.206  -13.744 48.876  1.00 137.90 ? 518 GLU C CD  1 
ATOM 9482  O OE1 . GLU C 1 524 ? 21.137  -14.298 48.557  1.00 144.19 ? 518 GLU C OE1 1 
ATOM 9483  O OE2 . GLU C 1 524 ? 22.423  -12.525 48.699  1.00 119.35 ? 518 GLU C OE2 1 
ATOM 9484  N N   . LYS C 1 525 ? 22.217  -13.429 52.159  1.00 75.29  ? 519 LYS C N   1 
ATOM 9485  C CA  . LYS C 1 525 ? 22.527  -12.009 52.387  1.00 77.01  ? 519 LYS C CA  1 
ATOM 9486  C C   . LYS C 1 525 ? 23.192  -11.962 53.751  1.00 67.04  ? 519 LYS C C   1 
ATOM 9487  O O   . LYS C 1 525 ? 24.201  -11.267 53.883  1.00 55.09  ? 519 LYS C O   1 
ATOM 9488  C CB  . LYS C 1 525 ? 21.230  -11.201 52.325  1.00 88.64  ? 519 LYS C CB  1 
ATOM 9489  C CG  . LYS C 1 525 ? 19.950  -11.998 52.539  1.00 99.49  ? 519 LYS C CG  1 
ATOM 9490  C CD  . LYS C 1 525 ? 19.342  -12.591 51.274  1.00 104.47 ? 519 LYS C CD  1 
ATOM 9491  C CE  . LYS C 1 525 ? 18.618  -11.582 50.443  1.00 108.39 ? 519 LYS C CE  1 
ATOM 9492  N NZ  . LYS C 1 525 ? 19.290  -11.348 49.162  1.00 113.67 ? 519 LYS C NZ  1 
ATOM 9493  N N   . GLU C 1 526 ? 22.671  -12.737 54.694  1.00 66.74  ? 520 GLU C N   1 
ATOM 9494  C CA  . GLU C 1 526 ? 23.210  -12.731 56.072  1.00 73.31  ? 520 GLU C CA  1 
ATOM 9495  C C   . GLU C 1 526 ? 24.658  -13.221 56.054  1.00 70.19  ? 520 GLU C C   1 
ATOM 9496  O O   . GLU C 1 526 ? 25.489  -12.653 56.780  1.00 61.90  ? 520 GLU C O   1 
ATOM 9497  C CB  . GLU C 1 526 ? 22.288  -13.600 56.922  1.00 80.01  ? 520 GLU C CB  1 
ATOM 9498  C CG  . GLU C 1 526 ? 20.986  -12.910 57.312  1.00 86.64  ? 520 GLU C CG  1 
ATOM 9499  C CD  . GLU C 1 526 ? 20.578  -13.141 58.756  1.00 97.48  ? 520 GLU C CD  1 
ATOM 9500  O OE1 . GLU C 1 526 ? 21.126  -12.458 59.644  1.00 103.79 ? 520 GLU C OE1 1 
ATOM 9501  O OE2 . GLU C 1 526 ? 19.708  -14.001 58.994  1.00 91.75  ? 520 GLU C OE2 1 
ATOM 9502  N N   . ARG C 1 527 ? 24.932  -14.245 55.253  1.00 67.04  ? 521 ARG C N   1 
ATOM 9503  C CA  . ARG C 1 527 ? 26.288  -14.820 55.181  1.00 62.38  ? 521 ARG C CA  1 
ATOM 9504  C C   . ARG C 1 527 ? 27.192  -13.807 54.517  1.00 56.76  ? 521 ARG C C   1 
ATOM 9505  O O   . ARG C 1 527 ? 28.266  -13.518 55.047  1.00 47.65  ? 521 ARG C O   1 
ATOM 9506  C CB  . ARG C 1 527 ? 26.250  -16.043 54.272  1.00 69.84  ? 521 ARG C CB  1 
ATOM 9507  C CG  . ARG C 1 527 ? 27.564  -16.790 54.114  1.00 74.31  ? 521 ARG C CG  1 
ATOM 9508  C CD  . ARG C 1 527 ? 27.333  -18.244 53.750  1.00 76.62  ? 521 ARG C CD  1 
ATOM 9509  N NE  . ARG C 1 527 ? 25.993  -18.705 54.128  1.00 73.67  ? 521 ARG C NE  1 
ATOM 9510  C CZ  . ARG C 1 527 ? 25.142  -19.271 53.289  1.00 72.82  ? 521 ARG C CZ  1 
ATOM 9511  N NH1 . ARG C 1 527 ? 25.199  -18.990 52.002  1.00 68.38  ? 521 ARG C NH1 1 
ATOM 9512  N NH2 . ARG C 1 527 ? 24.239  -20.120 53.739  1.00 74.55  ? 521 ARG C NH2 1 
ATOM 9513  N N   . GLN C 1 528 ? 26.733  -13.298 53.383  1.00 57.36  ? 522 GLN C N   1 
ATOM 9514  C CA  . GLN C 1 528 ? 27.557  -12.335 52.673  1.00 60.22  ? 522 GLN C CA  1 
ATOM 9515  C C   . GLN C 1 528 ? 27.983  -11.191 53.586  1.00 56.70  ? 522 GLN C C   1 
ATOM 9516  O O   . GLN C 1 528 ? 29.161  -10.832 53.637  1.00 56.49  ? 522 GLN C O   1 
ATOM 9517  C CB  . GLN C 1 528 ? 26.788  -11.706 51.520  1.00 62.78  ? 522 GLN C CB  1 
ATOM 9518  C CG  . GLN C 1 528 ? 26.432  -12.688 50.417  1.00 64.30  ? 522 GLN C CG  1 
ATOM 9519  C CD  . GLN C 1 528 ? 25.763  -11.991 49.258  1.00 66.14  ? 522 GLN C CD  1 
ATOM 9520  O OE1 . GLN C 1 528 ? 24.924  -11.096 49.439  1.00 61.12  ? 522 GLN C OE1 1 
ATOM 9521  N NE2 . GLN C 1 528 ? 26.165  -12.381 48.057  1.00 70.94  ? 522 GLN C NE2 1 
ATOM 9522  N N   . ILE C 1 529 ? 27.014  -10.607 54.289  1.00 51.07  ? 523 ILE C N   1 
ATOM 9523  C CA  . ILE C 1 529 ? 27.330  -9.475  55.136  1.00 54.17  ? 523 ILE C CA  1 
ATOM 9524  C C   . ILE C 1 529 ? 28.345  -9.910  56.193  1.00 55.91  ? 523 ILE C C   1 
ATOM 9525  O O   . ILE C 1 529 ? 29.257  -9.148  56.510  1.00 49.20  ? 523 ILE C O   1 
ATOM 9526  C CB  . ILE C 1 529 ? 26.070  -8.890  55.784  1.00 54.63  ? 523 ILE C CB  1 
ATOM 9527  C CG1 . ILE C 1 529 ? 25.052  -8.418  54.751  1.00 52.48  ? 523 ILE C CG1 1 
ATOM 9528  C CG2 . ILE C 1 529 ? 26.463  -7.765  56.745  1.00 56.57  ? 523 ILE C CG2 1 
ATOM 9529  C CD1 . ILE C 1 529 ? 23.634  -8.397  55.291  1.00 54.12  ? 523 ILE C CD1 1 
ATOM 9530  N N   . LYS C 1 530 ? 28.155  -11.123 56.740  1.00 59.09  ? 524 LYS C N   1 
ATOM 9531  C CA  . LYS C 1 530 ? 29.014  -11.650 57.792  1.00 60.79  ? 524 LYS C CA  1 
ATOM 9532  C C   . LYS C 1 530 ? 30.421  -11.883 57.239  1.00 61.46  ? 524 LYS C C   1 
ATOM 9533  O O   . LYS C 1 530 ? 31.413  -11.604 57.914  1.00 64.17  ? 524 LYS C O   1 
ATOM 9534  C CB  . LYS C 1 530 ? 28.418  -12.921 58.414  1.00 63.24  ? 524 LYS C CB  1 
ATOM 9535  C CG  . LYS C 1 530 ? 29.171  -13.456 59.632  1.00 67.40  ? 524 LYS C CG  1 
ATOM 9536  C CD  . LYS C 1 530 ? 28.387  -14.407 60.534  1.00 73.59  ? 524 LYS C CD  1 
ATOM 9537  C CE  . LYS C 1 530 ? 29.044  -14.673 61.874  1.00 81.73  ? 524 LYS C CE  1 
ATOM 9538  N NZ  . LYS C 1 530 ? 29.205  -13.475 62.710  1.00 83.24  ? 524 LYS C NZ  1 
ATOM 9539  N N   . LYS C 1 531 ? 30.510  -12.394 56.007  1.00 57.09  ? 525 LYS C N   1 
ATOM 9540  C CA  . LYS C 1 531 ? 31.802  -12.601 55.374  1.00 56.74  ? 525 LYS C CA  1 
ATOM 9541  C C   . LYS C 1 531 ? 32.431  -11.252 55.032  1.00 52.68  ? 525 LYS C C   1 
ATOM 9542  O O   . LYS C 1 531 ? 33.642  -11.071 55.152  1.00 48.16  ? 525 LYS C O   1 
ATOM 9543  C CB  . LYS C 1 531 ? 31.659  -13.498 54.141  1.00 60.49  ? 525 LYS C CB  1 
ATOM 9544  C CG  . LYS C 1 531 ? 31.338  -14.954 54.459  1.00 67.52  ? 525 LYS C CG  1 
ATOM 9545  C CD  . LYS C 1 531 ? 31.492  -15.948 53.308  1.00 71.25  ? 525 LYS C CD  1 
ATOM 9546  C CE  . LYS C 1 531 ? 30.552  -15.692 52.161  1.00 76.33  ? 525 LYS C CE  1 
ATOM 9547  N NZ  . LYS C 1 531 ? 30.490  -16.807 51.210  1.00 79.76  ? 525 LYS C NZ  1 
ATOM 9548  N N   . GLN C 1 532 ? 31.595  -10.302 54.610  1.00 52.17  ? 526 GLN C N   1 
ATOM 9549  C CA  . GLN C 1 532 ? 32.075  -8.970  54.268  1.00 56.34  ? 526 GLN C CA  1 
ATOM 9550  C C   . GLN C 1 532 ? 32.541  -8.233  55.523  1.00 50.02  ? 526 GLN C C   1 
ATOM 9551  O O   . GLN C 1 532 ? 33.669  -7.738  55.591  1.00 44.26  ? 526 GLN C O   1 
ATOM 9552  C CB  . GLN C 1 532 ? 30.990  -8.225  53.490  1.00 59.39  ? 526 GLN C CB  1 
ATOM 9553  C CG  . GLN C 1 532 ? 30.888  -8.661  52.030  1.00 55.20  ? 526 GLN C CG  1 
ATOM 9554  C CD  . GLN C 1 532 ? 29.756  -7.993  51.288  1.00 53.24  ? 526 GLN C CD  1 
ATOM 9555  O OE1 . GLN C 1 532 ? 28.740  -7.573  51.861  1.00 51.41  ? 526 GLN C OE1 1 
ATOM 9556  N NE2 . GLN C 1 532 ? 29.930  -7.907  49.981  1.00 56.15  ? 526 GLN C NE2 1 
ATOM 9557  N N   . THR C 1 533 ? 31.670  -8.206  56.532  1.00 52.03  ? 527 THR C N   1 
ATOM 9558  C CA  . THR C 1 533 ? 31.990  -7.580  57.807  1.00 55.04  ? 527 THR C CA  1 
ATOM 9559  C C   . THR C 1 533 ? 33.395  -8.002  58.247  1.00 50.62  ? 527 THR C C   1 
ATOM 9560  O O   . THR C 1 533 ? 34.142  -7.199  58.808  1.00 40.03  ? 527 THR C O   1 
ATOM 9561  C CB  . THR C 1 533 ? 30.918  -7.927  58.845  1.00 53.71  ? 527 THR C CB  1 
ATOM 9562  O OG1 . THR C 1 533 ? 29.687  -7.359  58.379  1.00 49.04  ? 527 THR C OG1 1 
ATOM 9563  C CG2 . THR C 1 533 ? 31.286  -7.417  60.230  1.00 53.98  ? 527 THR C CG2 1 
ATOM 9564  N N   . ALA C 1 534 ? 33.735  -9.269  57.981  1.00 54.98  ? 528 ALA C N   1 
ATOM 9565  C CA  . ALA C 1 534 ? 35.030  -9.812  58.347  1.00 58.67  ? 528 ALA C CA  1 
ATOM 9566  C C   . ALA C 1 534 ? 36.116  -9.232  57.437  1.00 56.21  ? 528 ALA C C   1 
ATOM 9567  O O   . ALA C 1 534 ? 37.202  -8.867  57.896  1.00 48.38  ? 528 ALA C O   1 
ATOM 9568  C CB  . ALA C 1 534 ? 34.960  -11.322 58.294  1.00 59.89  ? 528 ALA C CB  1 
ATOM 9569  N N   . LEU C 1 535 ? 35.804  -9.132  56.141  1.00 57.89  ? 529 LEU C N   1 
ATOM 9570  C CA  . LEU C 1 535 ? 36.762  -8.619  55.177  1.00 59.04  ? 529 LEU C CA  1 
ATOM 9571  C C   . LEU C 1 535 ? 37.218  -7.238  55.633  1.00 59.32  ? 529 LEU C C   1 
ATOM 9572  O O   . LEU C 1 535 ? 38.417  -6.975  55.737  1.00 58.29  ? 529 LEU C O   1 
ATOM 9573  C CB  . LEU C 1 535 ? 36.180  -8.577  53.764  1.00 52.86  ? 529 LEU C CB  1 
ATOM 9574  C CG  . LEU C 1 535 ? 37.166  -8.194  52.653  1.00 52.87  ? 529 LEU C CG  1 
ATOM 9575  C CD1 . LEU C 1 535 ? 38.379  -9.099  52.555  1.00 50.62  ? 529 LEU C CD1 1 
ATOM 9576  C CD2 . LEU C 1 535 ? 36.452  -8.177  51.323  1.00 55.60  ? 529 LEU C CD2 1 
ATOM 9577  N N   . VAL C 1 536 ? 36.241  -6.377  55.922  1.00 57.41  ? 530 VAL C N   1 
ATOM 9578  C CA  . VAL C 1 536 ? 36.532  -5.035  56.394  1.00 66.69  ? 530 VAL C CA  1 
ATOM 9579  C C   . VAL C 1 536 ? 37.574  -5.119  57.514  1.00 71.65  ? 530 VAL C C   1 
ATOM 9580  O O   . VAL C 1 536 ? 38.652  -4.517  57.404  1.00 64.72  ? 530 VAL C O   1 
ATOM 9581  C CB  . VAL C 1 536 ? 35.238  -4.312  56.833  1.00 64.46  ? 530 VAL C CB  1 
ATOM 9582  C CG1 . VAL C 1 536 ? 35.516  -3.048  57.638  1.00 62.64  ? 530 VAL C CG1 1 
ATOM 9583  C CG2 . VAL C 1 536 ? 34.334  -3.988  55.645  1.00 62.85  ? 530 VAL C CG2 1 
ATOM 9584  N N   . GLU C 1 537 ? 37.247  -5.906  58.557  1.00 69.44  ? 531 GLU C N   1 
ATOM 9585  C CA  . GLU C 1 537 ? 37.976  -5.900  59.817  1.00 65.98  ? 531 GLU C CA  1 
ATOM 9586  C C   . GLU C 1 537 ? 39.375  -6.451  59.601  1.00 63.34  ? 531 GLU C C   1 
ATOM 9587  O O   . GLU C 1 537 ? 40.290  -6.149  60.374  1.00 61.85  ? 531 GLU C O   1 
ATOM 9588  C CB  . GLU C 1 537 ? 37.292  -6.743  60.893  1.00 68.92  ? 531 GLU C CB  1 
ATOM 9589  C CG  . GLU C 1 537 ? 35.975  -6.161  61.398  1.00 76.12  ? 531 GLU C CG  1 
ATOM 9590  C CD  . GLU C 1 537 ? 36.127  -4.929  62.273  1.00 86.13  ? 531 GLU C CD  1 
ATOM 9591  O OE1 . GLU C 1 537 ? 37.301  -4.566  62.527  1.00 85.35  ? 531 GLU C OE1 1 
ATOM 9592  O OE2 . GLU C 1 537 ? 35.095  -4.344  62.700  1.00 88.14  ? 531 GLU C OE2 1 
ATOM 9593  N N   . LEU C 1 538 ? 39.492  -7.293  58.568  1.00 64.43  ? 532 LEU C N   1 
ATOM 9594  C CA  . LEU C 1 538 ? 40.774  -7.822  58.144  1.00 67.67  ? 532 LEU C CA  1 
ATOM 9595  C C   . LEU C 1 538 ? 41.601  -6.667  57.604  1.00 64.40  ? 532 LEU C C   1 
ATOM 9596  O O   . LEU C 1 538 ? 42.760  -6.503  57.973  1.00 57.74  ? 532 LEU C O   1 
ATOM 9597  C CB  . LEU C 1 538 ? 40.578  -8.921  57.101  1.00 70.88  ? 532 LEU C CB  1 
ATOM 9598  C CG  . LEU C 1 538 ? 41.844  -9.414  56.394  1.00 74.22  ? 532 LEU C CG  1 
ATOM 9599  C CD1 . LEU C 1 538 ? 42.921  -9.914  57.336  1.00 67.87  ? 532 LEU C CD1 1 
ATOM 9600  C CD2 . LEU C 1 538 ? 41.466  -10.508 55.416  1.00 80.47  ? 532 LEU C CD2 1 
ATOM 9601  N N   . VAL C 1 539 ? 40.978  -5.855  56.746  1.00 71.23  ? 533 VAL C N   1 
ATOM 9602  C CA  . VAL C 1 539 ? 41.698  -4.761  56.118  1.00 74.56  ? 533 VAL C CA  1 
ATOM 9603  C C   . VAL C 1 539 ? 42.220  -3.870  57.243  1.00 66.57  ? 533 VAL C C   1 
ATOM 9604  O O   . VAL C 1 539 ? 43.420  -3.616  57.315  1.00 66.13  ? 533 VAL C O   1 
ATOM 9605  C CB  . VAL C 1 539 ? 40.899  -3.967  55.062  1.00 73.39  ? 533 VAL C CB  1 
ATOM 9606  C CG1 . VAL C 1 539 ? 41.830  -3.179  54.152  1.00 71.95  ? 533 VAL C CG1 1 
ATOM 9607  C CG2 . VAL C 1 539 ? 40.010  -4.863  54.207  1.00 71.84  ? 533 VAL C CG2 1 
ATOM 9608  N N   . LYS C 1 540 ? 41.328  -3.493  58.166  1.00 60.54  ? 534 LYS C N   1 
ATOM 9609  C CA  . LYS C 1 540 ? 41.655  -2.549  59.226  1.00 66.30  ? 534 LYS C CA  1 
ATOM 9610  C C   . LYS C 1 540 ? 42.812  -3.045  60.095  1.00 70.34  ? 534 LYS C C   1 
ATOM 9611  O O   . LYS C 1 540 ? 43.510  -2.225  60.691  1.00 71.71  ? 534 LYS C O   1 
ATOM 9612  C CB  . LYS C 1 540 ? 40.445  -2.253  60.122  1.00 64.34  ? 534 LYS C CB  1 
ATOM 9613  C CG  . LYS C 1 540 ? 39.297  -1.505  59.455  1.00 59.77  ? 534 LYS C CG  1 
ATOM 9614  C CD  . LYS C 1 540 ? 38.075  -1.262  60.336  1.00 57.59  ? 534 LYS C CD  1 
ATOM 9615  C CE  . LYS C 1 540 ? 36.955  -0.606  59.577  1.00 56.72  ? 534 LYS C CE  1 
ATOM 9616  N NZ  . LYS C 1 540 ? 35.820  -0.194  60.404  1.00 54.82  ? 534 LYS C NZ  1 
ATOM 9617  N N   . HIS C 1 541 ? 43.098  -4.340  60.062  1.00 74.92  ? 535 HIS C N   1 
ATOM 9618  C CA  . HIS C 1 541 ? 44.186  -4.897  60.906  1.00 80.69  ? 535 HIS C CA  1 
ATOM 9619  C C   . HIS C 1 541 ? 45.461  -4.944  60.078  1.00 80.20  ? 535 HIS C C   1 
ATOM 9620  O O   . HIS C 1 541 ? 46.555  -4.710  60.609  1.00 85.39  ? 535 HIS C O   1 
ATOM 9621  C CB  . HIS C 1 541 ? 43.815  -6.287  61.419  1.00 87.18  ? 535 HIS C CB  1 
ATOM 9622  C CG  . HIS C 1 541 ? 44.911  -7.042  62.090  1.00 94.24  ? 535 HIS C CG  1 
ATOM 9623  N ND1 . HIS C 1 541 ? 44.994  -8.414  62.011  1.00 94.73  ? 535 HIS C ND1 1 
ATOM 9624  C CD2 . HIS C 1 541 ? 45.944  -6.654  62.842  1.00 96.82  ? 535 HIS C CD2 1 
ATOM 9625  C CE1 . HIS C 1 541 ? 46.050  -8.826  62.692  1.00 100.19 ? 535 HIS C CE1 1 
ATOM 9626  N NE2 . HIS C 1 541 ? 46.641  -7.773  63.205  1.00 105.22 ? 535 HIS C NE2 1 
ATOM 9627  N N   . LYS C 1 542 ? 45.309  -5.240  58.796  1.00 84.01  ? 536 LYS C N   1 
ATOM 9628  C CA  . LYS C 1 542 ? 46.479  -5.292  57.889  1.00 85.85  ? 536 LYS C CA  1 
ATOM 9629  C C   . LYS C 1 542 ? 46.113  -4.449  56.670  1.00 82.46  ? 536 LYS C C   1 
ATOM 9630  O O   . LYS C 1 542 ? 45.817  -5.019  55.614  1.00 81.97  ? 536 LYS C O   1 
ATOM 9631  C CB  . LYS C 1 542 ? 46.844  -6.741  57.565  1.00 87.25  ? 536 LYS C CB  1 
ATOM 9632  C CG  . LYS C 1 542 ? 47.306  -7.576  58.746  1.00 93.35  ? 536 LYS C CG  1 
ATOM 9633  C CD  . LYS C 1 542 ? 48.617  -7.088  59.349  1.00 103.52 ? 536 LYS C CD  1 
ATOM 9634  C CE  . LYS C 1 542 ? 49.604  -6.675  58.307  1.00 123.68 ? 536 LYS C CE  1 
ATOM 9635  N NZ  . LYS C 1 542 ? 50.961  -7.126  58.622  1.00 132.91 ? 536 LYS C NZ  1 
ATOM 9636  N N   . PRO C 1 543 ? 46.104  -3.112  56.796  1.00 85.48  ? 537 PRO C N   1 
ATOM 9637  C CA  . PRO C 1 543 ? 45.666  -2.255  55.711  1.00 89.52  ? 537 PRO C CA  1 
ATOM 9638  C C   . PRO C 1 543 ? 46.721  -1.880  54.696  1.00 93.78  ? 537 PRO C C   1 
ATOM 9639  O O   . PRO C 1 543 ? 46.654  -0.765  54.158  1.00 92.16  ? 537 PRO C O   1 
ATOM 9640  C CB  . PRO C 1 543 ? 45.199  -1.027  56.493  1.00 93.15  ? 537 PRO C CB  1 
ATOM 9641  C CG  . PRO C 1 543 ? 45.509  -1.308  57.948  1.00 95.05  ? 537 PRO C CG  1 
ATOM 9642  C CD  . PRO C 1 543 ? 46.556  -2.388  57.952  1.00 88.32  ? 537 PRO C CD  1 
ATOM 9643  N N   . LYS C 1 544 ? 47.643  -2.792  54.406  1.00 100.81 ? 538 LYS C N   1 
ATOM 9644  C CA  . LYS C 1 544 ? 48.727  -2.509  53.477  1.00 97.24  ? 538 LYS C CA  1 
ATOM 9645  C C   . LYS C 1 544 ? 48.880  -3.625  52.446  1.00 98.61  ? 538 LYS C C   1 
ATOM 9646  O O   . LYS C 1 544 ? 49.196  -3.346  51.289  1.00 104.36 ? 538 LYS C O   1 
ATOM 9647  C CB  . LYS C 1 544 ? 50.009  -2.291  54.286  1.00 96.48  ? 538 LYS C CB  1 
ATOM 9648  C CG  . LYS C 1 544 ? 49.921  -1.137  55.275  1.00 98.30  ? 538 LYS C CG  1 
ATOM 9649  C CD  . LYS C 1 544 ? 49.681  0.221   54.625  1.00 97.33  ? 538 LYS C CD  1 
ATOM 9650  C CE  . LYS C 1 544 ? 49.660  1.347   55.609  1.00 98.27  ? 538 LYS C CE  1 
ATOM 9651  N NZ  . LYS C 1 544 ? 49.697  2.637   54.916  1.00 101.81 ? 538 LYS C NZ  1 
ATOM 9652  N N   . ALA C 1 545 ? 48.657  -4.876  52.868  1.00 90.78  ? 539 ALA C N   1 
ATOM 9653  C CA  . ALA C 1 545 ? 48.930  -6.032  52.031  1.00 92.22  ? 539 ALA C CA  1 
ATOM 9654  C C   . ALA C 1 545 ? 48.305  -5.863  50.644  1.00 88.19  ? 539 ALA C C   1 
ATOM 9655  O O   . ALA C 1 545 ? 47.207  -5.330  50.508  1.00 82.19  ? 539 ALA C O   1 
ATOM 9656  C CB  . ALA C 1 545 ? 48.442  -7.270  52.741  1.00 97.16  ? 539 ALA C CB  1 
ATOM 9657  N N   . THR C 1 546 ? 49.030  -6.316  49.614  1.00 87.92  ? 540 THR C N   1 
ATOM 9658  C CA  . THR C 1 546 ? 48.629  -6.121  48.227  1.00 99.88  ? 540 THR C CA  1 
ATOM 9659  C C   . THR C 1 546 ? 47.399  -6.976  47.909  1.00 100.51 ? 540 THR C C   1 
ATOM 9660  O O   . THR C 1 546 ? 47.085  -7.909  48.640  1.00 113.43 ? 540 THR C O   1 
ATOM 9661  C CB  . THR C 1 546 ? 49.821  -6.427  47.312  1.00 106.04 ? 540 THR C CB  1 
ATOM 9662  O OG1 . THR C 1 546 ? 49.399  -6.134  45.982  1.00 115.16 ? 540 THR C OG1 1 
ATOM 9663  C CG2 . THR C 1 546 ? 50.317  -7.862  47.387  1.00 100.75 ? 540 THR C CG2 1 
ATOM 9664  N N   . LYS C 1 547 ? 46.722  -6.666  46.793  1.00 89.29  ? 541 LYS C N   1 
ATOM 9665  C CA  . LYS C 1 547 ? 45.449  -7.284  46.452  1.00 86.13  ? 541 LYS C CA  1 
ATOM 9666  C C   . LYS C 1 547 ? 45.620  -8.742  46.032  1.00 86.59  ? 541 LYS C C   1 
ATOM 9667  O O   . LYS C 1 547 ? 44.618  -9.420  45.807  1.00 83.56  ? 541 LYS C O   1 
ATOM 9668  C CB  . LYS C 1 547 ? 44.754  -6.538  45.310  1.00 87.32  ? 541 LYS C CB  1 
ATOM 9669  C CG  . LYS C 1 547 ? 45.518  -6.502  43.990  1.00 89.29  ? 541 LYS C CG  1 
ATOM 9670  C CD  . LYS C 1 547 ? 44.777  -5.797  42.857  1.00 93.83  ? 541 LYS C CD  1 
ATOM 9671  C CE  . LYS C 1 547 ? 43.580  -6.551  42.359  1.00 92.05  ? 541 LYS C CE  1 
ATOM 9672  N NZ  . LYS C 1 547 ? 43.952  -7.833  41.758  1.00 88.07  ? 541 LYS C NZ  1 
ATOM 9673  N N   . GLU C 1 548 ? 46.878  -9.200  45.907  1.00 94.59  ? 542 GLU C N   1 
ATOM 9674  C CA  . GLU C 1 548 ? 47.191  -10.562 45.487  1.00 106.43 ? 542 GLU C CA  1 
ATOM 9675  C C   . GLU C 1 548 ? 47.456  -11.444 46.713  1.00 90.44  ? 542 GLU C C   1 
ATOM 9676  O O   . GLU C 1 548 ? 47.259  -12.658 46.679  1.00 79.23  ? 542 GLU C O   1 
ATOM 9677  C CB  . GLU C 1 548 ? 48.371  -10.616 44.506  1.00 107.52 ? 542 GLU C CB  1 
ATOM 9678  C CG  . GLU C 1 548 ? 48.232  -9.725  43.270  1.00 101.35 ? 542 GLU C CG  1 
ATOM 9679  C CD  . GLU C 1 548 ? 48.469  -8.235  43.491  1.00 108.40 ? 542 GLU C CD  1 
ATOM 9680  O OE1 . GLU C 1 548 ? 48.721  -7.876  44.665  1.00 112.79 ? 542 GLU C OE1 1 
ATOM 9681  O OE2 . GLU C 1 548 ? 48.409  -7.434  42.519  1.00 94.14  ? 542 GLU C OE2 1 
ATOM 9682  N N   . GLN C 1 549 ? 47.914  -10.826 47.802  1.00 83.32  ? 543 GLN C N   1 
ATOM 9683  C CA  . GLN C 1 549 ? 47.941  -11.484 49.098  1.00 86.69  ? 543 GLN C CA  1 
ATOM 9684  C C   . GLN C 1 549 ? 46.523  -11.645 49.648  1.00 81.67  ? 543 GLN C C   1 
ATOM 9685  O O   . GLN C 1 549 ? 46.222  -12.656 50.277  1.00 83.56  ? 543 GLN C O   1 
ATOM 9686  C CB  . GLN C 1 549 ? 48.737  -10.667 50.115  1.00 89.80  ? 543 GLN C CB  1 
ATOM 9687  C CG  . GLN C 1 549 ? 50.240  -10.613 49.871  1.00 90.78  ? 543 GLN C CG  1 
ATOM 9688  C CD  . GLN C 1 549 ? 50.931  -9.728  50.885  1.00 92.59  ? 543 GLN C CD  1 
ATOM 9689  O OE1 . GLN C 1 549 ? 50.545  -8.574  51.106  1.00 89.78  ? 543 GLN C OE1 1 
ATOM 9690  N NE2 . GLN C 1 549 ? 51.943  -10.271 51.543  1.00 97.52  ? 543 GLN C NE2 1 
ATOM 9691  N N   . LEU C 1 550 ? 45.674  -10.625 49.437  1.00 78.76  ? 544 LEU C N   1 
ATOM 9692  C CA  . LEU C 1 550 ? 44.301  -10.599 49.929  1.00 72.77  ? 544 LEU C CA  1 
ATOM 9693  C C   . LEU C 1 550 ? 43.408  -11.472 49.056  1.00 72.44  ? 544 LEU C C   1 
ATOM 9694  O O   . LEU C 1 550 ? 42.324  -11.846 49.492  1.00 70.13  ? 544 LEU C O   1 
ATOM 9695  C CB  . LEU C 1 550 ? 43.722  -9.187  49.933  1.00 74.50  ? 544 LEU C CB  1 
ATOM 9696  C CG  . LEU C 1 550 ? 44.260  -8.197  50.968  1.00 85.24  ? 544 LEU C CG  1 
ATOM 9697  C CD1 . LEU C 1 550 ? 45.625  -8.575  51.509  1.00 91.37  ? 544 LEU C CD1 1 
ATOM 9698  C CD2 . LEU C 1 550 ? 44.319  -6.814  50.326  1.00 91.66  ? 544 LEU C CD2 1 
ATOM 9699  N N   . LYS C 1 551 ? 43.812  -11.697 47.797  1.00 74.25  ? 545 LYS C N   1 
ATOM 9700  C CA  . LYS C 1 551 ? 43.180  -12.712 46.972  1.00 71.35  ? 545 LYS C CA  1 
ATOM 9701  C C   . LYS C 1 551 ? 43.515  -14.085 47.553  1.00 71.74  ? 545 LYS C C   1 
ATOM 9702  O O   . LYS C 1 551 ? 42.642  -14.938 47.664  1.00 77.41  ? 545 LYS C O   1 
ATOM 9703  C CB  . LYS C 1 551 ? 43.575  -12.659 45.496  1.00 73.23  ? 545 LYS C CB  1 
ATOM 9704  C CG  . LYS C 1 551 ? 42.734  -13.596 44.635  1.00 81.67  ? 545 LYS C CG  1 
ATOM 9705  C CD  . LYS C 1 551 ? 43.144  -13.656 43.174  1.00 91.03  ? 545 LYS C CD  1 
ATOM 9706  C CE  . LYS C 1 551 ? 44.519  -14.224 43.016  1.00 96.23  ? 545 LYS C CE  1 
ATOM 9707  N NZ  . LYS C 1 551 ? 44.834  -14.402 41.599  1.00 100.19 ? 545 LYS C NZ  1 
ATOM 9708  N N   . ALA C 1 552 ? 44.775  -14.286 47.954  1.00 75.93  ? 546 ALA C N   1 
ATOM 9709  C CA  . ALA C 1 552 ? 45.199  -15.537 48.574  1.00 76.35  ? 546 ALA C CA  1 
ATOM 9710  C C   . ALA C 1 552 ? 44.336  -15.876 49.792  1.00 72.79  ? 546 ALA C C   1 
ATOM 9711  O O   . ALA C 1 552 ? 43.957  -17.029 49.975  1.00 69.21  ? 546 ALA C O   1 
ATOM 9712  C CB  . ALA C 1 552 ? 46.665  -15.462 48.951  1.00 74.99  ? 546 ALA C CB  1 
ATOM 9713  N N   . VAL C 1 553 ? 44.020  -14.865 50.613  1.00 68.02  ? 547 VAL C N   1 
ATOM 9714  C CA  . VAL C 1 553 ? 43.298  -15.079 51.856  1.00 66.20  ? 547 VAL C CA  1 
ATOM 9715  C C   . VAL C 1 553 ? 41.806  -15.315 51.602  1.00 67.99  ? 547 VAL C C   1 
ATOM 9716  O O   . VAL C 1 553 ? 41.252  -16.217 52.220  1.00 72.83  ? 547 VAL C O   1 
ATOM 9717  C CB  . VAL C 1 553 ? 43.555  -13.930 52.851  1.00 62.69  ? 547 VAL C CB  1 
ATOM 9718  C CG1 . VAL C 1 553 ? 42.482  -13.805 53.930  1.00 57.95  ? 547 VAL C CG1 1 
ATOM 9719  C CG2 . VAL C 1 553 ? 44.929  -14.073 53.488  1.00 59.99  ? 547 VAL C CG2 1 
ATOM 9720  N N   . MET C 1 554 ? 41.148  -14.538 50.724  1.00 66.66  ? 548 MET C N   1 
ATOM 9721  C CA  . MET C 1 554 ? 39.716  -14.723 50.496  1.00 72.37  ? 548 MET C CA  1 
ATOM 9722  C C   . MET C 1 554 ? 39.487  -16.048 49.751  1.00 69.95  ? 548 MET C C   1 
ATOM 9723  O O   . MET C 1 554 ? 38.411  -16.633 49.860  1.00 72.44  ? 548 MET C O   1 
ATOM 9724  C CB  . MET C 1 554 ? 39.065  -13.543 49.746  1.00 82.89  ? 548 MET C CB  1 
ATOM 9725  C CG  . MET C 1 554 ? 37.692  -13.033 50.297  1.00 97.26  ? 548 MET C CG  1 
ATOM 9726  S SD  . MET C 1 554 ? 36.265  -14.117 50.624  1.00 111.38 ? 548 MET C SD  1 
ATOM 9727  C CE  . MET C 1 554 ? 35.019  -14.173 49.324  1.00 82.56  ? 548 MET C CE  1 
ATOM 9728  N N   . ASP C 1 555 ? 40.496  -16.543 49.014  1.00 69.52  ? 549 ASP C N   1 
ATOM 9729  C CA  . ASP C 1 555 ? 40.409  -17.840 48.346  1.00 77.43  ? 549 ASP C CA  1 
ATOM 9730  C C   . ASP C 1 555 ? 40.556  -18.998 49.345  1.00 82.24  ? 549 ASP C C   1 
ATOM 9731  O O   . ASP C 1 555 ? 39.902  -20.028 49.185  1.00 84.15  ? 549 ASP C O   1 
ATOM 9732  C CB  . ASP C 1 555 ? 41.416  -17.957 47.208  1.00 81.03  ? 549 ASP C CB  1 
ATOM 9733  C CG  . ASP C 1 555 ? 41.088  -17.186 45.932  1.00 89.04  ? 549 ASP C CG  1 
ATOM 9734  O OD1 . ASP C 1 555 ? 39.976  -16.600 45.850  1.00 88.23  ? 549 ASP C OD1 1 
ATOM 9735  O OD2 . ASP C 1 555 ? 41.952  -17.168 45.022  1.00 88.22  ? 549 ASP C OD2 1 
ATOM 9736  N N   . ASP C 1 556 ? 41.436  -18.845 50.349  1.00 79.18  ? 550 ASP C N   1 
ATOM 9737  C CA  . ASP C 1 556 ? 41.584  -19.802 51.439  1.00 73.16  ? 550 ASP C CA  1 
ATOM 9738  C C   . ASP C 1 556 ? 40.317  -19.845 52.292  1.00 66.22  ? 550 ASP C C   1 
ATOM 9739  O O   . ASP C 1 556 ? 39.889  -20.901 52.750  1.00 63.80  ? 550 ASP C O   1 
ATOM 9740  C CB  . ASP C 1 556 ? 42.760  -19.438 52.330  1.00 76.64  ? 550 ASP C CB  1 
ATOM 9741  C CG  . ASP C 1 556 ? 44.133  -19.744 51.757  1.00 89.96  ? 550 ASP C CG  1 
ATOM 9742  O OD1 . ASP C 1 556 ? 44.198  -20.190 50.591  1.00 100.70 ? 550 ASP C OD1 1 
ATOM 9743  O OD2 . ASP C 1 556 ? 45.124  -19.562 52.493  1.00 101.46 ? 550 ASP C OD2 1 
ATOM 9744  N N   . PHE C 1 557 ? 39.753  -18.663 52.534  1.00 62.35  ? 551 PHE C N   1 
ATOM 9745  C CA  . PHE C 1 557 ? 38.514  -18.538 53.271  1.00 60.21  ? 551 PHE C CA  1 
ATOM 9746  C C   . PHE C 1 557 ? 37.405  -19.269 52.528  1.00 60.25  ? 551 PHE C C   1 
ATOM 9747  O O   . PHE C 1 557 ? 36.606  -19.967 53.138  1.00 67.73  ? 551 PHE C O   1 
ATOM 9748  C CB  . PHE C 1 557 ? 38.130  -17.072 53.463  1.00 56.41  ? 551 PHE C CB  1 
ATOM 9749  C CG  . PHE C 1 557 ? 37.089  -16.913 54.553  1.00 57.31  ? 551 PHE C CG  1 
ATOM 9750  C CD1 . PHE C 1 557 ? 37.468  -16.936 55.890  1.00 56.49  ? 551 PHE C CD1 1 
ATOM 9751  C CD2 . PHE C 1 557 ? 35.740  -16.771 54.238  1.00 62.59  ? 551 PHE C CD2 1 
ATOM 9752  C CE1 . PHE C 1 557 ? 36.518  -16.812 56.891  1.00 60.06  ? 551 PHE C CE1 1 
ATOM 9753  C CE2 . PHE C 1 557 ? 34.791  -16.644 55.244  1.00 65.13  ? 551 PHE C CE2 1 
ATOM 9754  C CZ  . PHE C 1 557 ? 35.182  -16.673 56.568  1.00 63.30  ? 551 PHE C CZ  1 
ATOM 9755  N N   . ALA C 1 558 ? 37.355  -19.084 51.211  1.00 61.96  ? 552 ALA C N   1 
ATOM 9756  C CA  . ALA C 1 558 ? 36.340  -19.719 50.390  1.00 65.75  ? 552 ALA C CA  1 
ATOM 9757  C C   . ALA C 1 558 ? 36.401  -21.236 50.547  1.00 68.57  ? 552 ALA C C   1 
ATOM 9758  O O   . ALA C 1 558 ? 35.360  -21.878 50.667  1.00 64.86  ? 552 ALA C O   1 
ATOM 9759  C CB  . ALA C 1 558 ? 36.534  -19.310 48.953  1.00 68.64  ? 552 ALA C CB  1 
ATOM 9760  N N   . ALA C 1 559 ? 37.624  -21.787 50.529  1.00 73.55  ? 553 ALA C N   1 
ATOM 9761  C CA  . ALA C 1 559 ? 37.854  -23.210 50.738  1.00 83.59  ? 553 ALA C CA  1 
ATOM 9762  C C   . ALA C 1 559 ? 37.385  -23.606 52.137  1.00 85.94  ? 553 ALA C C   1 
ATOM 9763  O O   . ALA C 1 559 ? 36.523  -24.469 52.292  1.00 87.38  ? 553 ALA C O   1 
ATOM 9764  C CB  . ALA C 1 559 ? 39.325  -23.542 50.542  1.00 84.39  ? 553 ALA C CB  1 
ATOM 9765  N N   . PHE C 1 560 ? 37.964  -22.936 53.139  1.00 82.14  ? 554 PHE C N   1 
ATOM 9766  C CA  . PHE C 1 560 ? 37.687  -23.184 54.541  1.00 73.25  ? 554 PHE C CA  1 
ATOM 9767  C C   . PHE C 1 560 ? 36.193  -23.369 54.799  1.00 66.93  ? 554 PHE C C   1 
ATOM 9768  O O   . PHE C 1 560 ? 35.815  -24.255 55.555  1.00 70.24  ? 554 PHE C O   1 
ATOM 9769  C CB  . PHE C 1 560 ? 38.240  -21.974 55.292  1.00 78.82  ? 554 PHE C CB  1 
ATOM 9770  C CG  . PHE C 1 560 ? 37.986  -21.999 56.791  1.00 88.99  ? 554 PHE C CG  1 
ATOM 9771  C CD1 . PHE C 1 560 ? 38.866  -22.669 57.626  1.00 88.83  ? 554 PHE C CD1 1 
ATOM 9772  C CD2 . PHE C 1 560 ? 36.888  -21.350 57.364  1.00 91.17  ? 554 PHE C CD2 1 
ATOM 9773  C CE1 . PHE C 1 560 ? 38.653  -22.690 58.991  1.00 86.33  ? 554 PHE C CE1 1 
ATOM 9774  C CE2 . PHE C 1 560 ? 36.683  -21.381 58.737  1.00 84.14  ? 554 PHE C CE2 1 
ATOM 9775  C CZ  . PHE C 1 560 ? 37.568  -22.052 59.546  1.00 81.98  ? 554 PHE C CZ  1 
ATOM 9776  N N   . VAL C 1 561 ? 35.357  -22.501 54.212  1.00 62.47  ? 555 VAL C N   1 
ATOM 9777  C CA  . VAL C 1 561 ? 33.932  -22.472 54.506  1.00 62.90  ? 555 VAL C CA  1 
ATOM 9778  C C   . VAL C 1 561 ? 33.251  -23.666 53.836  1.00 63.37  ? 555 VAL C C   1 
ATOM 9779  O O   . VAL C 1 561 ? 32.396  -24.290 54.453  1.00 60.02  ? 555 VAL C O   1 
ATOM 9780  C CB  . VAL C 1 561 ? 33.277  -21.125 54.114  1.00 62.65  ? 555 VAL C CB  1 
ATOM 9781  C CG1 . VAL C 1 561 ? 31.748  -21.157 54.128  1.00 62.36  ? 555 VAL C CG1 1 
ATOM 9782  C CG2 . VAL C 1 561 ? 33.768  -19.990 55.005  1.00 61.68  ? 555 VAL C CG2 1 
ATOM 9783  N N   . GLU C 1 562 ? 33.631  -23.986 52.590  1.00 70.71  ? 556 GLU C N   1 
ATOM 9784  C CA  . GLU C 1 562 ? 32.970  -25.042 51.834  1.00 77.69  ? 556 GLU C CA  1 
ATOM 9785  C C   . GLU C 1 562 ? 33.306  -26.424 52.395  1.00 74.76  ? 556 GLU C C   1 
ATOM 9786  O O   . GLU C 1 562 ? 32.447  -27.310 52.391  1.00 81.03  ? 556 GLU C O   1 
ATOM 9787  C CB  . GLU C 1 562 ? 33.311  -25.041 50.343  1.00 83.48  ? 556 GLU C CB  1 
ATOM 9788  C CG  . GLU C 1 562 ? 32.587  -26.168 49.612  1.00 89.53  ? 556 GLU C CG  1 
ATOM 9789  C CD  . GLU C 1 562 ? 31.925  -25.753 48.325  1.00 88.18  ? 556 GLU C CD  1 
ATOM 9790  O OE1 . GLU C 1 562 ? 32.639  -25.203 47.449  1.00 82.46  ? 556 GLU C OE1 1 
ATOM 9791  O OE2 . GLU C 1 562 ? 30.690  -25.982 48.249  1.00 76.19  ? 556 GLU C OE2 1 
ATOM 9792  N N   . LYS C 1 563 ? 34.564  -26.594 52.833  1.00 65.21  ? 557 LYS C N   1 
ATOM 9793  C CA  . LYS C 1 563 ? 35.043  -27.811 53.479  1.00 57.76  ? 557 LYS C CA  1 
ATOM 9794  C C   . LYS C 1 563 ? 34.242  -28.098 54.754  1.00 52.88  ? 557 LYS C C   1 
ATOM 9795  O O   . LYS C 1 563 ? 33.641  -29.166 54.918  1.00 46.65  ? 557 LYS C O   1 
ATOM 9796  C CB  . LYS C 1 563 ? 36.537  -27.646 53.784  1.00 57.96  ? 557 LYS C CB  1 
ATOM 9797  C CG  . LYS C 1 563 ? 37.123  -28.680 54.731  1.00 68.11  ? 557 LYS C CG  1 
ATOM 9798  C CD  . LYS C 1 563 ? 38.628  -28.555 54.922  1.00 77.84  ? 557 LYS C CD  1 
ATOM 9799  C CE  . LYS C 1 563 ? 39.217  -29.768 55.575  1.00 82.59  ? 557 LYS C CE  1 
ATOM 9800  N NZ  . LYS C 1 563 ? 40.680  -29.747 55.492  1.00 85.68  ? 557 LYS C NZ  1 
ATOM 9801  N N   . CYS C 1 564 ? 34.231  -27.108 55.648  1.00 51.38  ? 558 CYS C N   1 
ATOM 9802  C CA  . CYS C 1 564 ? 33.617  -27.240 56.951  1.00 51.24  ? 558 CYS C CA  1 
ATOM 9803  C C   . CYS C 1 564 ? 32.106  -27.371 56.813  1.00 53.73  ? 558 CYS C C   1 
ATOM 9804  O O   . CYS C 1 564 ? 31.502  -27.976 57.682  1.00 76.79  ? 558 CYS C O   1 
ATOM 9805  C CB  . CYS C 1 564 ? 34.052  -26.100 57.861  1.00 52.23  ? 558 CYS C CB  1 
ATOM 9806  S SG  . CYS C 1 564 ? 35.854  -26.023 58.084  1.00 59.55  ? 558 CYS C SG  1 
ATOM 9807  N N   . CYS C 1 565 ? 31.512  -26.862 55.724  1.00 57.28  ? 559 CYS C N   1 
ATOM 9808  C CA  . CYS C 1 565 ? 30.068  -26.920 55.513  1.00 68.25  ? 559 CYS C CA  1 
ATOM 9809  C C   . CYS C 1 565 ? 29.605  -28.331 55.154  1.00 68.69  ? 559 CYS C C   1 
ATOM 9810  O O   . CYS C 1 565 ? 28.418  -28.628 55.270  1.00 68.65  ? 559 CYS C O   1 
ATOM 9811  C CB  . CYS C 1 565 ? 29.610  -25.994 54.389  1.00 83.42  ? 559 CYS C CB  1 
ATOM 9812  S SG  . CYS C 1 565 ? 29.548  -24.234 54.832  1.00 101.03 ? 559 CYS C SG  1 
ATOM 9813  N N   . LYS C 1 566 ? 30.542  -29.169 54.689  1.00 71.07  ? 560 LYS C N   1 
ATOM 9814  C CA  . LYS C 1 566 ? 30.251  -30.536 54.293  1.00 74.76  ? 560 LYS C CA  1 
ATOM 9815  C C   . LYS C 1 566 ? 30.871  -31.531 55.278  1.00 70.04  ? 560 LYS C C   1 
ATOM 9816  O O   . LYS C 1 566 ? 30.606  -32.726 55.182  1.00 73.01  ? 560 LYS C O   1 
ATOM 9817  C CB  . LYS C 1 566 ? 30.703  -30.683 52.836  1.00 88.55  ? 560 LYS C CB  1 
ATOM 9818  C CG  . LYS C 1 566 ? 29.917  -29.775 51.880  1.00 104.76 ? 560 LYS C CG  1 
ATOM 9819  C CD  . LYS C 1 566 ? 30.149  -29.963 50.383  1.00 110.90 ? 560 LYS C CD  1 
ATOM 9820  C CE  . LYS C 1 566 ? 31.473  -29.455 49.901  1.00 111.78 ? 560 LYS C CE  1 
ATOM 9821  N NZ  . LYS C 1 566 ? 31.442  -29.140 48.469  1.00 112.06 ? 560 LYS C NZ  1 
ATOM 9822  N N   . ALA C 1 567 ? 31.661  -31.037 56.242  1.00 65.30  ? 561 ALA C N   1 
ATOM 9823  C CA  . ALA C 1 567 ? 32.240  -31.859 57.300  1.00 61.72  ? 561 ALA C CA  1 
ATOM 9824  C C   . ALA C 1 567 ? 31.162  -32.467 58.199  1.00 61.87  ? 561 ALA C C   1 
ATOM 9825  O O   . ALA C 1 567 ? 30.093  -31.894 58.392  1.00 56.15  ? 561 ALA C O   1 
ATOM 9826  C CB  . ALA C 1 567 ? 33.203  -31.041 58.130  1.00 57.78  ? 561 ALA C CB  1 
ATOM 9827  N N   . ASP C 1 568 ? 31.483  -33.630 58.774  1.00 62.51  ? 562 ASP C N   1 
ATOM 9828  C CA  . ASP C 1 568 ? 30.516  -34.424 59.513  1.00 61.87  ? 562 ASP C CA  1 
ATOM 9829  C C   . ASP C 1 568 ? 30.277  -33.769 60.866  1.00 58.80  ? 562 ASP C C   1 
ATOM 9830  O O   . ASP C 1 568 ? 29.138  -33.672 61.293  1.00 56.55  ? 562 ASP C O   1 
ATOM 9831  C CB  . ASP C 1 568 ? 30.916  -35.894 59.564  1.00 65.43  ? 562 ASP C CB  1 
ATOM 9832  C CG  . ASP C 1 568 ? 30.627  -36.682 58.290  1.00 74.29  ? 562 ASP C CG  1 
ATOM 9833  O OD1 . ASP C 1 568 ? 29.441  -36.763 57.912  1.00 83.34  ? 562 ASP C OD1 1 
ATOM 9834  O OD2 . ASP C 1 568 ? 31.581  -37.198 57.660  1.00 86.88  ? 562 ASP C OD2 1 
ATOM 9835  N N   . ASP C 1 569 ? 31.354  -33.320 61.521  1.00 65.63  ? 563 ASP C N   1 
ATOM 9836  C CA  . ASP C 1 569 ? 31.247  -32.406 62.649  1.00 69.79  ? 563 ASP C CA  1 
ATOM 9837  C C   . ASP C 1 569 ? 31.601  -30.994 62.191  1.00 70.41  ? 563 ASP C C   1 
ATOM 9838  O O   . ASP C 1 569 ? 32.768  -30.609 62.216  1.00 69.84  ? 563 ASP C O   1 
ATOM 9839  C CB  . ASP C 1 569 ? 32.142  -32.796 63.815  1.00 72.20  ? 563 ASP C CB  1 
ATOM 9840  C CG  . ASP C 1 569 ? 32.016  -31.912 65.051  1.00 69.29  ? 563 ASP C CG  1 
ATOM 9841  O OD1 . ASP C 1 569 ? 31.255  -30.920 64.990  1.00 66.68  ? 563 ASP C OD1 1 
ATOM 9842  O OD2 . ASP C 1 569 ? 32.666  -32.228 66.070  1.00 65.23  ? 563 ASP C OD2 1 
ATOM 9843  N N   . LYS C 1 570 ? 30.570  -30.230 61.817  1.00 74.06  ? 564 LYS C N   1 
ATOM 9844  C CA  . LYS C 1 570 ? 30.710  -28.855 61.359  1.00 73.89  ? 564 LYS C CA  1 
ATOM 9845  C C   . LYS C 1 570 ? 31.592  -28.038 62.311  1.00 72.59  ? 564 LYS C C   1 
ATOM 9846  O O   . LYS C 1 570 ? 32.509  -27.334 61.877  1.00 62.18  ? 564 LYS C O   1 
ATOM 9847  C CB  . LYS C 1 570 ? 29.330  -28.182 61.305  1.00 79.68  ? 564 LYS C CB  1 
ATOM 9848  C CG  . LYS C 1 570 ? 28.220  -28.846 60.463  1.00 88.79  ? 564 LYS C CG  1 
ATOM 9849  C CD  . LYS C 1 570 ? 28.042  -28.331 59.034  1.00 88.30  ? 564 LYS C CD  1 
ATOM 9850  C CE  . LYS C 1 570 ? 26.866  -28.902 58.274  1.00 87.25  ? 564 LYS C CE  1 
ATOM 9851  N NZ  . LYS C 1 570 ? 27.001  -30.329 57.955  1.00 88.08  ? 564 LYS C NZ  1 
ATOM 9852  N N   . GLU C 1 571 ? 31.307  -28.126 63.619  1.00 68.78  ? 565 GLU C N   1 
ATOM 9853  C CA  . GLU C 1 571 ? 31.808  -27.142 64.567  1.00 64.13  ? 565 GLU C CA  1 
ATOM 9854  C C   . GLU C 1 571 ? 33.259  -27.420 64.953  1.00 60.22  ? 565 GLU C C   1 
ATOM 9855  O O   . GLU C 1 571 ? 34.027  -26.492 65.182  1.00 63.75  ? 565 GLU C O   1 
ATOM 9856  C CB  . GLU C 1 571 ? 30.940  -27.038 65.819  1.00 65.38  ? 565 GLU C CB  1 
ATOM 9857  C CG  . GLU C 1 571 ? 31.260  -25.799 66.652  1.00 72.12  ? 565 GLU C CG  1 
ATOM 9858  C CD  . GLU C 1 571 ? 31.266  -24.506 65.843  1.00 75.95  ? 565 GLU C CD  1 
ATOM 9859  O OE1 . GLU C 1 571 ? 30.238  -24.252 65.164  1.00 74.17  ? 565 GLU C OE1 1 
ATOM 9860  O OE2 . GLU C 1 571 ? 32.288  -23.765 65.876  1.00 70.22  ? 565 GLU C OE2 1 
ATOM 9861  N N   . THR C 1 572 ? 33.631  -28.692 65.082  1.00 60.38  ? 566 THR C N   1 
ATOM 9862  C CA  . THR C 1 572 ? 35.027  -29.021 65.310  1.00 59.63  ? 566 THR C CA  1 
ATOM 9863  C C   . THR C 1 572 ? 35.826  -28.527 64.110  1.00 58.71  ? 566 THR C C   1 
ATOM 9864  O O   . THR C 1 572 ? 36.895  -27.943 64.277  1.00 56.16  ? 566 THR C O   1 
ATOM 9865  C CB  . THR C 1 572 ? 35.201  -30.522 65.540  1.00 59.62  ? 566 THR C CB  1 
ATOM 9866  O OG1 . THR C 1 572 ? 34.592  -30.683 66.815  1.00 58.62  ? 566 THR C OG1 1 
ATOM 9867  C CG2 . THR C 1 572 ? 36.657  -30.964 65.561  1.00 58.70  ? 566 THR C CG2 1 
ATOM 9868  N N   . CYS C 1 573 ? 35.278  -28.760 62.910  1.00 57.05  ? 567 CYS C N   1 
ATOM 9869  C CA  . CYS C 1 573 ? 35.956  -28.398 61.680  1.00 56.51  ? 567 CYS C CA  1 
ATOM 9870  C C   . CYS C 1 573 ? 36.211  -26.893 61.658  1.00 58.28  ? 567 CYS C C   1 
ATOM 9871  O O   . CYS C 1 573 ? 37.347  -26.467 61.466  1.00 51.56  ? 567 CYS C O   1 
ATOM 9872  C CB  . CYS C 1 573 ? 35.164  -28.840 60.460  1.00 56.82  ? 567 CYS C CB  1 
ATOM 9873  S SG  . CYS C 1 573 ? 36.207  -28.996 58.992  1.00 65.72  ? 567 CYS C SG  1 
ATOM 9874  N N   . PHE C 1 574 ? 35.158  -26.095 61.888  1.00 61.66  ? 568 PHE C N   1 
ATOM 9875  C CA  . PHE C 1 574 ? 35.325  -24.652 61.977  1.00 62.00  ? 568 PHE C CA  1 
ATOM 9876  C C   . PHE C 1 574 ? 36.448  -24.341 62.960  1.00 63.74  ? 568 PHE C C   1 
ATOM 9877  O O   . PHE C 1 574 ? 37.506  -23.873 62.537  1.00 66.59  ? 568 PHE C O   1 
ATOM 9878  C CB  . PHE C 1 574 ? 34.038  -23.916 62.356  1.00 61.47  ? 568 PHE C CB  1 
ATOM 9879  C CG  . PHE C 1 574 ? 33.159  -23.693 61.141  1.00 61.67  ? 568 PHE C CG  1 
ATOM 9880  C CD1 . PHE C 1 574 ? 33.576  -22.835 60.132  1.00 64.13  ? 568 PHE C CD1 1 
ATOM 9881  C CD2 . PHE C 1 574 ? 31.945  -24.351 61.004  1.00 65.71  ? 568 PHE C CD2 1 
ATOM 9882  C CE1 . PHE C 1 574 ? 32.793  -22.640 59.008  1.00 73.54  ? 568 PHE C CE1 1 
ATOM 9883  C CE2 . PHE C 1 574 ? 31.158  -24.144 59.884  1.00 72.53  ? 568 PHE C CE2 1 
ATOM 9884  C CZ  . PHE C 1 574 ? 31.581  -23.290 58.889  1.00 76.19  ? 568 PHE C CZ  1 
ATOM 9885  N N   . ALA C 1 575 ? 36.215  -24.647 64.247  1.00 62.95  ? 569 ALA C N   1 
ATOM 9886  C CA  . ALA C 1 575 ? 37.180  -24.423 65.317  1.00 62.25  ? 569 ALA C CA  1 
ATOM 9887  C C   . ALA C 1 575 ? 38.596  -24.868 64.926  1.00 65.71  ? 569 ALA C C   1 
ATOM 9888  O O   . ALA C 1 575 ? 39.547  -24.092 65.064  1.00 58.04  ? 569 ALA C O   1 
ATOM 9889  C CB  . ALA C 1 575 ? 36.711  -25.134 66.561  1.00 60.11  ? 569 ALA C CB  1 
ATOM 9890  N N   . GLU C 1 576 ? 38.732  -26.112 64.432  1.00 69.96  ? 570 GLU C N   1 
ATOM 9891  C CA  . GLU C 1 576 ? 40.035  -26.707 64.172  1.00 71.42  ? 570 GLU C CA  1 
ATOM 9892  C C   . GLU C 1 576 ? 40.680  -26.065 62.945  1.00 71.05  ? 570 GLU C C   1 
ATOM 9893  O O   . GLU C 1 576 ? 41.806  -25.592 63.032  1.00 84.25  ? 570 GLU C O   1 
ATOM 9894  C CB  . GLU C 1 576 ? 40.015  -28.233 64.035  1.00 76.90  ? 570 GLU C CB  1 
ATOM 9895  C CG  . GLU C 1 576 ? 39.881  -28.987 65.359  1.00 82.15  ? 570 GLU C CG  1 
ATOM 9896  C CD  . GLU C 1 576 ? 40.906  -28.695 66.464  1.00 96.07  ? 570 GLU C CD  1 
ATOM 9897  O OE1 . GLU C 1 576 ? 41.941  -28.003 66.279  1.00 90.85  ? 570 GLU C OE1 1 
ATOM 9898  O OE2 . GLU C 1 576 ? 40.641  -29.182 67.584  1.00 97.41  ? 570 GLU C OE2 1 
ATOM 9899  N N   . GLU C 1 577 ? 39.985  -26.036 61.806  1.00 69.42  ? 571 GLU C N   1 
ATOM 9900  C CA  . GLU C 1 577 ? 40.562  -25.463 60.593  1.00 74.52  ? 571 GLU C CA  1 
ATOM 9901  C C   . GLU C 1 577 ? 40.778  -23.958 60.765  1.00 74.21  ? 571 GLU C C   1 
ATOM 9902  O O   . GLU C 1 577 ? 41.668  -23.395 60.122  1.00 71.06  ? 571 GLU C O   1 
ATOM 9903  C CB  . GLU C 1 577 ? 39.730  -25.692 59.325  1.00 77.10  ? 571 GLU C CB  1 
ATOM 9904  C CG  . GLU C 1 577 ? 39.622  -27.153 58.891  1.00 75.61  ? 571 GLU C CG  1 
ATOM 9905  C CD  . GLU C 1 577 ? 40.945  -27.859 58.654  1.00 72.98  ? 571 GLU C CD  1 
ATOM 9906  O OE1 . GLU C 1 577 ? 41.526  -27.684 57.567  1.00 74.36  ? 571 GLU C OE1 1 
ATOM 9907  O OE2 . GLU C 1 577 ? 41.417  -28.559 59.572  1.00 72.00  ? 571 GLU C OE2 1 
ATOM 9908  N N   . GLY C 1 578 ? 39.931  -23.319 61.594  1.00 71.33  ? 572 GLY C N   1 
ATOM 9909  C CA  . GLY C 1 578 ? 39.997  -21.887 61.855  1.00 67.06  ? 572 GLY C CA  1 
ATOM 9910  C C   . GLY C 1 578 ? 41.392  -21.472 62.304  1.00 63.68  ? 572 GLY C C   1 
ATOM 9911  O O   . GLY C 1 578 ? 41.966  -20.535 61.757  1.00 57.75  ? 572 GLY C O   1 
ATOM 9912  N N   . LYS C 1 579 ? 41.916  -22.195 63.300  1.00 65.86  ? 573 LYS C N   1 
ATOM 9913  C CA  . LYS C 1 579 ? 43.264  -21.975 63.783  1.00 71.48  ? 573 LYS C CA  1 
ATOM 9914  C C   . LYS C 1 579 ? 44.235  -22.132 62.613  1.00 67.32  ? 573 LYS C C   1 
ATOM 9915  O O   . LYS C 1 579 ? 45.025  -21.229 62.337  1.00 59.85  ? 573 LYS C O   1 
ATOM 9916  C CB  . LYS C 1 579 ? 43.585  -22.910 64.959  1.00 79.38  ? 573 LYS C CB  1 
ATOM 9917  C CG  . LYS C 1 579 ? 42.932  -22.588 66.308  1.00 81.63  ? 573 LYS C CG  1 
ATOM 9918  C CD  . LYS C 1 579 ? 43.811  -22.982 67.495  1.00 89.93  ? 573 LYS C CD  1 
ATOM 9919  C CE  . LYS C 1 579 ? 44.272  -24.418 67.520  1.00 95.64  ? 573 LYS C CE  1 
ATOM 9920  N NZ  . LYS C 1 579 ? 43.226  -25.373 67.917  1.00 99.91  ? 573 LYS C NZ  1 
ATOM 9921  N N   . LYS C 1 580 ? 44.149  -23.269 61.912  1.00 68.66  ? 574 LYS C N   1 
ATOM 9922  C CA  . LYS C 1 580 ? 45.046  -23.561 60.804  1.00 77.26  ? 574 LYS C CA  1 
ATOM 9923  C C   . LYS C 1 580 ? 45.034  -22.423 59.780  1.00 79.43  ? 574 LYS C C   1 
ATOM 9924  O O   . LYS C 1 580 ? 46.063  -22.124 59.172  1.00 78.95  ? 574 LYS C O   1 
ATOM 9925  C CB  . LYS C 1 580 ? 44.692  -24.901 60.146  1.00 83.85  ? 574 LYS C CB  1 
ATOM 9926  C CG  . LYS C 1 580 ? 45.476  -26.102 60.649  1.00 91.56  ? 574 LYS C CG  1 
ATOM 9927  C CD  . LYS C 1 580 ? 45.353  -26.335 62.149  1.00 106.30 ? 574 LYS C CD  1 
ATOM 9928  C CE  . LYS C 1 580 ? 44.089  -27.056 62.501  1.00 114.74 ? 574 LYS C CE  1 
ATOM 9929  N NZ  . LYS C 1 580 ? 43.806  -27.020 63.941  1.00 118.29 ? 574 LYS C NZ  1 
ATOM 9930  N N   . LEU C 1 581 ? 43.866  -21.794 59.586  1.00 79.50  ? 575 LEU C N   1 
ATOM 9931  C CA  . LEU C 1 581 ? 43.712  -20.739 58.596  1.00 76.55  ? 575 LEU C CA  1 
ATOM 9932  C C   . LEU C 1 581 ? 44.376  -19.452 59.079  1.00 80.01  ? 575 LEU C C   1 
ATOM 9933  O O   . LEU C 1 581 ? 45.183  -18.876 58.355  1.00 93.39  ? 575 LEU C O   1 
ATOM 9934  C CB  . LEU C 1 581 ? 42.237  -20.487 58.296  1.00 72.54  ? 575 LEU C CB  1 
ATOM 9935  C CG  . LEU C 1 581 ? 41.957  -19.437 57.216  1.00 67.50  ? 575 LEU C CG  1 
ATOM 9936  C CD1 . LEU C 1 581 ? 42.425  -19.977 55.880  1.00 76.93  ? 575 LEU C CD1 1 
ATOM 9937  C CD2 . LEU C 1 581 ? 40.490  -19.039 57.155  1.00 60.00  ? 575 LEU C CD2 1 
ATOM 9938  N N   . VAL C 1 582 ? 43.991  -18.985 60.278  1.00 67.95  ? 576 VAL C N   1 
ATOM 9939  C CA  . VAL C 1 582 ? 44.576  -17.795 60.870  1.00 57.98  ? 576 VAL C CA  1 
ATOM 9940  C C   . VAL C 1 582 ? 46.088  -17.985 60.953  1.00 65.81  ? 576 VAL C C   1 
ATOM 9941  O O   . VAL C 1 582 ? 46.837  -17.068 60.639  1.00 76.22  ? 576 VAL C O   1 
ATOM 9942  C CB  . VAL C 1 582 ? 43.988  -17.489 62.259  1.00 54.81  ? 576 VAL C CB  1 
ATOM 9943  C CG1 . VAL C 1 582 ? 44.772  -16.409 62.987  1.00 58.49  ? 576 VAL C CG1 1 
ATOM 9944  C CG2 . VAL C 1 582 ? 42.522  -17.106 62.198  1.00 50.46  ? 576 VAL C CG2 1 
ATOM 9945  N N   . ALA C 1 583 ? 46.528  -19.181 61.366  1.00 69.55  ? 577 ALA C N   1 
ATOM 9946  C CA  . ALA C 1 583 ? 47.947  -19.484 61.495  1.00 73.50  ? 577 ALA C CA  1 
ATOM 9947  C C   . ALA C 1 583 ? 48.679  -19.120 60.208  1.00 70.00  ? 577 ALA C C   1 
ATOM 9948  O O   . ALA C 1 583 ? 49.667  -18.392 60.242  1.00 77.58  ? 577 ALA C O   1 
ATOM 9949  C CB  . ALA C 1 583 ? 48.155  -20.949 61.848  1.00 74.69  ? 577 ALA C CB  1 
ATOM 9950  N N   . ALA C 1 584 ? 48.122  -19.510 59.079  1.00 66.30  ? 578 ALA C N   1 
ATOM 9951  C CA  . ALA C 1 584 ? 48.814  -19.263 57.802  1.00 71.22  ? 578 ALA C CA  1 
ATOM 9952  C C   . ALA C 1 584 ? 48.604  -17.817 57.379  1.00 73.39  ? 578 ALA C C   1 
ATOM 9953  O O   . ALA C 1 584 ? 49.515  -17.207 56.799  1.00 70.86  ? 578 ALA C O   1 
ATOM 9954  C CB  . ALA C 1 584 ? 48.255  -20.196 56.780  1.00 73.53  ? 578 ALA C CB  1 
ATOM 9955  N N   . SER C 1 585 ? 47.414  -17.299 57.641  1.00 74.44  ? 579 SER C N   1 
ATOM 9956  C CA  . SER C 1 585 ? 47.087  -15.919 57.228  1.00 73.38  ? 579 SER C CA  1 
ATOM 9957  C C   . SER C 1 585 ? 48.023  -14.957 57.959  1.00 79.87  ? 579 SER C C   1 
ATOM 9958  O O   . SER C 1 585 ? 48.491  -14.004 57.328  1.00 83.69  ? 579 SER C O   1 
ATOM 9959  C CB  . SER C 1 585 ? 45.658  -15.647 57.540  1.00 66.45  ? 579 SER C CB  1 
ATOM 9960  O OG  . SER C 1 585 ? 44.837  -16.700 57.061  1.00 68.25  ? 579 SER C OG  1 
ATOM 9961  N N   . GLN C 1 586 ? 48.281  -15.212 59.235  1.00 84.48  ? 580 GLN C N   1 
ATOM 9962  C CA  . GLN C 1 586 ? 49.199  -14.375 60.051  1.00 87.03  ? 580 GLN C CA  1 
ATOM 9963  C C   . GLN C 1 586 ? 50.607  -14.469 59.447  1.00 85.68  ? 580 GLN C C   1 
ATOM 9964  O O   . GLN C 1 586 ? 51.311  -13.459 59.447  1.00 91.32  ? 580 GLN C O   1 
ATOM 9965  C CB  . GLN C 1 586 ? 49.056  -14.692 61.543  1.00 90.02  ? 580 GLN C CB  1 
ATOM 9966  C CG  . GLN C 1 586 ? 49.727  -15.977 62.004  1.00 87.94  ? 580 GLN C CG  1 
ATOM 9967  C CD  . GLN C 1 586 ? 49.180  -16.451 63.329  1.00 86.70  ? 580 GLN C CD  1 
ATOM 9968  O OE1 . GLN C 1 586 ? 48.240  -15.864 63.875  1.00 76.64  ? 580 GLN C OE1 1 
ATOM 9969  N NE2 . GLN C 1 586 ? 49.769  -17.512 63.862  1.00 92.70  ? 580 GLN C NE2 1 
ATOM 9970  N N   . ALA C 1 587 ? 51.009  -15.649 58.989  1.00 83.08  ? 581 ALA C N   1 
ATOM 9971  C CA  . ALA C 1 587 ? 52.383  -15.817 58.483  1.00 79.95  ? 581 ALA C CA  1 
ATOM 9972  C C   . ALA C 1 587 ? 52.523  -14.888 57.294  1.00 81.96  ? 581 ALA C C   1 
ATOM 9973  O O   . ALA C 1 587 ? 53.601  -14.293 57.129  1.00 81.86  ? 581 ALA C O   1 
ATOM 9974  C CB  . ALA C 1 587 ? 52.578  -17.230 58.053  1.00 80.53  ? 581 ALA C CB  1 
ATOM 9975  N N   . ALA C 1 588 ? 51.495  -14.806 56.458  1.00 86.13  ? 582 ALA C N   1 
ATOM 9976  C CA  . ALA C 1 588 ? 51.530  -13.769 55.411  1.00 88.94  ? 582 ALA C CA  1 
ATOM 9977  C C   . ALA C 1 588 ? 50.984  -12.528 56.089  1.00 91.52  ? 582 ALA C C   1 
ATOM 9978  O O   . ALA C 1 588 ? 49.866  -12.104 55.745  1.00 91.51  ? 582 ALA C O   1 
ATOM 9979  C CB  . ALA C 1 588 ? 50.650  -14.179 54.279  1.00 87.84  ? 582 ALA C CB  1 
ATOM 9980  N N   . LEU C 1 589 ? 51.770  -11.912 56.970  1.00 102.05 ? 583 LEU C N   1 
ATOM 9981  C CA  . LEU C 1 589 ? 51.154  -10.817 57.748  1.00 102.09 ? 583 LEU C CA  1 
ATOM 9982  C C   . LEU C 1 589 ? 50.752  -9.757  56.742  1.00 111.86 ? 583 LEU C C   1 
ATOM 9983  O O   . LEU C 1 589 ? 49.570  -9.390  56.753  1.00 98.85  ? 583 LEU C O   1 
ATOM 9984  C CB  . LEU C 1 589 ? 52.130  -10.277 58.785  1.00 94.35  ? 583 LEU C CB  1 
ATOM 9985  C CG  . LEU C 1 589 ? 51.785  -10.579 60.245  1.00 96.12  ? 583 LEU C CG  1 
ATOM 9986  C CD1 . LEU C 1 589 ? 52.976  -10.365 61.155  1.00 109.67 ? 583 LEU C CD1 1 
ATOM 9987  C CD2 . LEU C 1 589 ? 50.596  -9.769  60.715  1.00 90.22  ? 583 LEU C CD2 1 
ATOM 9988  N N   . GLY C 1 590 ? 51.611  -9.492  55.764  1.00 138.70 ? 584 GLY C N   1 
ATOM 9989  C CA  . GLY C 1 590 ? 51.342  -8.420  54.785  1.00 142.52 ? 584 GLY C CA  1 
ATOM 9990  C C   . GLY C 1 590 ? 52.356  -7.301  54.903  1.00 139.84 ? 584 GLY C C   1 
ATOM 9991  O O   . GLY C 1 590 ? 53.495  -7.496  54.495  1.00 148.88 ? 584 GLY C O   1 
ATOM 9992  N N   . GLU D 2 1   ? 6.468   39.636  22.174  1.00 139.94 ? 1   GLU D N   1 
ATOM 9993  C CA  . GLU D 2 1   ? 6.660   38.484  21.249  1.00 141.46 ? 1   GLU D CA  1 
ATOM 9994  C C   . GLU D 2 1   ? 7.939   38.659  20.423  1.00 143.77 ? 1   GLU D C   1 
ATOM 9995  O O   . GLU D 2 1   ? 8.420   39.780  20.228  1.00 130.87 ? 1   GLU D O   1 
ATOM 9996  C CB  . GLU D 2 1   ? 5.429   38.231  20.368  1.00 126.32 ? 1   GLU D CB  1 
ATOM 9997  C CG  . GLU D 2 1   ? 4.756   36.884  20.632  1.00 119.32 ? 1   GLU D CG  1 
ATOM 9998  C CD  . GLU D 2 1   ? 5.643   35.676  20.329  1.00 117.35 ? 1   GLU D CD  1 
ATOM 9999  O OE1 . GLU D 2 1   ? 6.605   35.381  21.085  1.00 109.05 ? 1   GLU D OE1 1 
ATOM 10000 O OE2 . GLU D 2 1   ? 5.395   35.032  19.289  1.00 115.02 ? 1   GLU D OE2 1 
ATOM 10001 N N   . VAL D 2 2   ? 8.464   37.518  19.938  1.00 131.87 ? 2   VAL D N   1 
ATOM 10002 C CA  . VAL D 2 2   ? 9.694   37.459  19.160  1.00 102.10 ? 2   VAL D CA  1 
ATOM 10003 C C   . VAL D 2 2   ? 9.396   37.873  17.724  1.00 79.24  ? 2   VAL D C   1 
ATOM 10004 O O   . VAL D 2 2   ? 9.275   37.014  16.861  1.00 69.87  ? 2   VAL D O   1 
ATOM 10005 C CB  . VAL D 2 2   ? 10.322  36.053  19.187  1.00 98.28  ? 2   VAL D CB  1 
ATOM 10006 C CG1 . VAL D 2 2   ? 11.689  36.039  18.494  1.00 90.18  ? 2   VAL D CG1 1 
ATOM 10007 C CG2 . VAL D 2 2   ? 10.395  35.498  20.610  1.00 100.72 ? 2   VAL D CG2 1 
ATOM 10008 N N   . GLN D 2 3   ? 9.272   39.184  17.487  1.00 69.96  ? 3   GLN D N   1 
ATOM 10009 C CA  . GLN D 2 3   ? 8.988   39.699  16.161  1.00 68.25  ? 3   GLN D CA  1 
ATOM 10010 C C   . GLN D 2 3   ? 10.257  39.580  15.324  1.00 62.24  ? 3   GLN D C   1 
ATOM 10011 O O   . GLN D 2 3   ? 11.355  39.475  15.867  1.00 65.10  ? 3   GLN D O   1 
ATOM 10012 C CB  . GLN D 2 3   ? 8.570   41.171  16.195  1.00 79.97  ? 3   GLN D CB  1 
ATOM 10013 C CG  . GLN D 2 3   ? 9.763   42.124  16.177  1.00 94.40  ? 3   GLN D CG  1 
ATOM 10014 C CD  . GLN D 2 3   ? 9.430   43.596  16.281  1.00 104.25 ? 3   GLN D CD  1 
ATOM 10015 O OE1 . GLN D 2 3   ? 10.040  44.420  15.590  1.00 98.88  ? 3   GLN D OE1 1 
ATOM 10016 N NE2 . GLN D 2 3   ? 8.530   43.954  17.189  1.00 115.37 ? 3   GLN D NE2 1 
ATOM 10017 N N   . LEU D 2 4   ? 10.088  39.595  14.001  1.00 56.51  ? 4   LEU D N   1 
ATOM 10018 C CA  . LEU D 2 4   ? 11.169  39.885  13.071  1.00 57.33  ? 4   LEU D CA  1 
ATOM 10019 C C   . LEU D 2 4   ? 10.687  40.989  12.123  1.00 64.65  ? 4   LEU D C   1 
ATOM 10020 O O   . LEU D 2 4   ? 9.492   41.113  11.868  1.00 79.44  ? 4   LEU D O   1 
ATOM 10021 C CB  . LEU D 2 4   ? 11.554  38.606  12.327  1.00 54.45  ? 4   LEU D CB  1 
ATOM 10022 C CG  . LEU D 2 4   ? 12.069  37.437  13.174  1.00 50.86  ? 4   LEU D CG  1 
ATOM 10023 C CD1 . LEU D 2 4   ? 11.986  36.119  12.424  1.00 52.51  ? 4   LEU D CD1 1 
ATOM 10024 C CD2 . LEU D 2 4   ? 13.491  37.671  13.625  1.00 48.84  ? 4   LEU D CD2 1 
ATOM 10025 N N   . VAL D 2 5   ? 11.606  41.818  11.623  1.00 65.09  ? 5   VAL D N   1 
ATOM 10026 C CA  . VAL D 2 5   ? 11.242  42.947  10.781  1.00 65.50  ? 5   VAL D CA  1 
ATOM 10027 C C   . VAL D 2 5   ? 12.288  43.078  9.690   1.00 70.28  ? 5   VAL D C   1 
ATOM 10028 O O   . VAL D 2 5   ? 13.468  43.017  9.996   1.00 85.71  ? 5   VAL D O   1 
ATOM 10029 C CB  . VAL D 2 5   ? 11.175  44.233  11.619  1.00 66.51  ? 5   VAL D CB  1 
ATOM 10030 C CG1 . VAL D 2 5   ? 11.364  45.488  10.770  1.00 65.44  ? 5   VAL D CG1 1 
ATOM 10031 C CG2 . VAL D 2 5   ? 9.892   44.286  12.439  1.00 66.68  ? 5   VAL D CG2 1 
ATOM 10032 N N   . GLU D 2 6   ? 11.861  43.282  8.442   1.00 70.63  ? 6   GLU D N   1 
ATOM 10033 C CA  . GLU D 2 6   ? 12.803  43.330  7.334   1.00 75.77  ? 6   GLU D CA  1 
ATOM 10034 C C   . GLU D 2 6   ? 12.660  44.658  6.602   1.00 74.20  ? 6   GLU D C   1 
ATOM 10035 O O   . GLU D 2 6   ? 11.595  45.269  6.635   1.00 77.89  ? 6   GLU D O   1 
ATOM 10036 C CB  . GLU D 2 6   ? 12.636  42.190  6.327   1.00 78.65  ? 6   GLU D CB  1 
ATOM 10037 C CG  . GLU D 2 6   ? 12.528  40.803  6.956   1.00 76.56  ? 6   GLU D CG  1 
ATOM 10038 C CD  . GLU D 2 6   ? 11.103  40.296  7.086   1.00 73.71  ? 6   GLU D CD  1 
ATOM 10039 O OE1 . GLU D 2 6   ? 10.242  41.070  7.545   1.00 72.11  ? 6   GLU D OE1 1 
ATOM 10040 O OE2 . GLU D 2 6   ? 10.851  39.123  6.739   1.00 71.40  ? 6   GLU D OE2 1 
ATOM 10041 N N   . SER D 2 7   ? 13.739  45.058  5.917   1.00 71.72  ? 7   SER D N   1 
ATOM 10042 C CA  . SER D 2 7   ? 13.808  46.337  5.229   1.00 72.00  ? 7   SER D CA  1 
ATOM 10043 C C   . SER D 2 7   ? 15.104  46.435  4.426   1.00 69.55  ? 7   SER D C   1 
ATOM 10044 O O   . SER D 2 7   ? 16.085  45.770  4.744   1.00 72.49  ? 7   SER D O   1 
ATOM 10045 C CB  . SER D 2 7   ? 13.729  47.464  6.213   1.00 74.70  ? 7   SER D CB  1 
ATOM 10046 O OG  . SER D 2 7   ? 14.744  47.287  7.189   1.00 78.36  ? 7   SER D OG  1 
ATOM 10047 N N   . GLY D 2 8   ? 15.112  47.321  3.426   1.00 65.96  ? 8   GLY D N   1 
ATOM 10048 C CA  . GLY D 2 8   ? 16.258  47.507  2.548   1.00 62.64  ? 8   GLY D CA  1 
ATOM 10049 C C   . GLY D 2 8   ? 15.885  47.188  1.103   1.00 61.49  ? 8   GLY D C   1 
ATOM 10050 O O   . GLY D 2 8   ? 16.615  47.506  0.162   1.00 59.71  ? 8   GLY D O   1 
ATOM 10051 N N   . GLY D 2 9   ? 14.717  46.564  0.947   1.00 55.62  ? 9   GLY D N   1 
ATOM 10052 C CA  . GLY D 2 9   ? 14.277  46.114  -0.353  1.00 60.29  ? 9   GLY D CA  1 
ATOM 10053 C C   . GLY D 2 9   ? 13.877  47.286  -1.240  1.00 64.84  ? 9   GLY D C   1 
ATOM 10054 O O   . GLY D 2 9   ? 13.507  48.352  -0.749  1.00 59.45  ? 9   GLY D O   1 
ATOM 10055 N N   . GLY D 2 10  ? 13.956  47.033  -2.552  1.00 70.07  ? 10  GLY D N   1 
ATOM 10056 C CA  . GLY D 2 10  ? 13.541  47.958  -3.586  1.00 66.63  ? 10  GLY D CA  1 
ATOM 10057 C C   . GLY D 2 10  ? 13.916  47.394  -4.951  1.00 66.86  ? 10  GLY D C   1 
ATOM 10058 O O   . GLY D 2 10  ? 14.140  46.194  -5.091  1.00 57.87  ? 10  GLY D O   1 
ATOM 10059 N N   . LEU D 2 11  ? 13.974  48.284  -5.944  1.00 75.61  ? 11  LEU D N   1 
ATOM 10060 C CA  . LEU D 2 11  ? 14.375  47.933  -7.295  1.00 77.45  ? 11  LEU D CA  1 
ATOM 10061 C C   . LEU D 2 11  ? 15.856  48.271  -7.455  1.00 73.75  ? 11  LEU D C   1 
ATOM 10062 O O   . LEU D 2 11  ? 16.380  49.140  -6.764  1.00 69.70  ? 11  LEU D O   1 
ATOM 10063 C CB  . LEU D 2 11  ? 13.472  48.690  -8.269  1.00 76.69  ? 11  LEU D CB  1 
ATOM 10064 C CG  . LEU D 2 11  ? 13.491  48.201  -9.717  1.00 82.48  ? 11  LEU D CG  1 
ATOM 10065 C CD1 . LEU D 2 11  ? 12.169  48.478  -10.420 1.00 84.97  ? 11  LEU D CD1 1 
ATOM 10066 C CD2 . LEU D 2 11  ? 14.638  48.861  -10.469 1.00 92.57  ? 11  LEU D CD2 1 
ATOM 10067 N N   . VAL D 2 12  ? 16.550  47.558  -8.344  1.00 72.31  ? 12  VAL D N   1 
ATOM 10068 C CA  . VAL D 2 12  ? 17.962  47.832  -8.537  1.00 75.88  ? 12  VAL D CA  1 
ATOM 10069 C C   . VAL D 2 12  ? 18.436  47.336  -9.902  1.00 73.21  ? 12  VAL D C   1 
ATOM 10070 O O   . VAL D 2 12  ? 17.952  46.340  -10.430 1.00 71.43  ? 12  VAL D O   1 
ATOM 10071 C CB  . VAL D 2 12  ? 18.772  47.243  -7.362  1.00 76.88  ? 12  VAL D CB  1 
ATOM 10072 C CG1 . VAL D 2 12  ? 18.093  46.019  -6.757  1.00 77.94  ? 12  VAL D CG1 1 
ATOM 10073 C CG2 . VAL D 2 12  ? 20.227  46.948  -7.731  1.00 73.29  ? 12  VAL D CG2 1 
ATOM 10074 N N   . GLN D 2 13  ? 19.391  48.087  -10.458 1.00 76.58  ? 13  GLN D N   1 
ATOM 10075 C CA  . GLN D 2 13  ? 20.077  47.744  -11.687 1.00 80.48  ? 13  GLN D CA  1 
ATOM 10076 C C   . GLN D 2 13  ? 20.713  46.371  -11.568 1.00 83.07  ? 13  GLN D C   1 
ATOM 10077 O O   . GLN D 2 13  ? 21.374  46.089  -10.566 1.00 90.90  ? 13  GLN D O   1 
ATOM 10078 C CB  . GLN D 2 13  ? 21.270  48.663  -11.953 1.00 85.46  ? 13  GLN D CB  1 
ATOM 10079 C CG  . GLN D 2 13  ? 21.040  49.702  -13.043 1.00 87.46  ? 13  GLN D CG  1 
ATOM 10080 C CD  . GLN D 2 13  ? 22.254  50.575  -13.280 1.00 83.92  ? 13  GLN D CD  1 
ATOM 10081 O OE1 . GLN D 2 13  ? 23.412  50.159  -13.115 1.00 69.78  ? 13  GLN D OE1 1 
ATOM 10082 N NE2 . GLN D 2 13  ? 21.989  51.822  -13.631 1.00 86.98  ? 13  GLN D NE2 1 
ATOM 10083 N N   . PRO D 2 14  ? 20.557  45.517  -12.605 1.00 67.33  ? 14  PRO D N   1 
ATOM 10084 C CA  . PRO D 2 14  ? 21.382  44.316  -12.745 1.00 61.57  ? 14  PRO D CA  1 
ATOM 10085 C C   . PRO D 2 14  ? 22.864  44.657  -12.585 1.00 60.62  ? 14  PRO D C   1 
ATOM 10086 O O   . PRO D 2 14  ? 23.352  45.595  -13.213 1.00 54.47  ? 14  PRO D O   1 
ATOM 10087 C CB  . PRO D 2 14  ? 21.037  43.841  -14.154 1.00 62.78  ? 14  PRO D CB  1 
ATOM 10088 C CG  . PRO D 2 14  ? 19.638  44.350  -14.398 1.00 63.51  ? 14  PRO D CG  1 
ATOM 10089 C CD  . PRO D 2 14  ? 19.561  45.672  -13.673 1.00 60.51  ? 14  PRO D CD  1 
ATOM 10090 N N   . GLY D 2 15  ? 23.553  43.916  -11.705 1.00 63.41  ? 15  GLY D N   1 
ATOM 10091 C CA  . GLY D 2 15  ? 24.953  44.166  -11.390 1.00 68.43  ? 15  GLY D CA  1 
ATOM 10092 C C   . GLY D 2 15  ? 25.144  45.008  -10.124 1.00 72.23  ? 15  GLY D C   1 
ATOM 10093 O O   . GLY D 2 15  ? 26.286  45.186  -9.680  1.00 67.23  ? 15  GLY D O   1 
ATOM 10094 N N   . GLY D 2 16  ? 24.031  45.509  -9.549  1.00 70.30  ? 16  GLY D N   1 
ATOM 10095 C CA  . GLY D 2 16  ? 24.065  46.446  -8.431  1.00 71.27  ? 16  GLY D CA  1 
ATOM 10096 C C   . GLY D 2 16  ? 24.051  45.755  -7.061  1.00 72.81  ? 16  GLY D C   1 
ATOM 10097 O O   . GLY D 2 16  ? 24.150  44.532  -6.971  1.00 74.57  ? 16  GLY D O   1 
ATOM 10098 N N   . SER D 2 17  ? 23.911  46.562  -5.992  1.00 68.16  ? 17  SER D N   1 
ATOM 10099 C CA  . SER D 2 17  ? 23.890  46.084  -4.612  1.00 60.08  ? 17  SER D CA  1 
ATOM 10100 C C   . SER D 2 17  ? 22.584  46.444  -3.888  1.00 61.05  ? 17  SER D C   1 
ATOM 10101 O O   . SER D 2 17  ? 21.836  47.337  -4.278  1.00 61.83  ? 17  SER D O   1 
ATOM 10102 C CB  . SER D 2 17  ? 25.082  46.602  -3.816  1.00 53.41  ? 17  SER D CB  1 
ATOM 10103 O OG  . SER D 2 17  ? 26.256  45.836  -4.036  1.00 46.35  ? 17  SER D OG  1 
ATOM 10104 N N   . LEU D 2 18  ? 22.323  45.695  -2.814  1.00 66.38  ? 18  LEU D N   1 
ATOM 10105 C CA  . LEU D 2 18  ? 21.299  45.976  -1.820  1.00 69.68  ? 18  LEU D CA  1 
ATOM 10106 C C   . LEU D 2 18  ? 21.821  45.405  -0.506  1.00 68.29  ? 18  LEU D C   1 
ATOM 10107 O O   . LEU D 2 18  ? 22.559  44.422  -0.511  1.00 67.98  ? 18  LEU D O   1 
ATOM 10108 C CB  . LEU D 2 18  ? 19.940  45.347  -2.139  1.00 78.36  ? 18  LEU D CB  1 
ATOM 10109 C CG  . LEU D 2 18  ? 18.899  46.205  -2.864  1.00 88.57  ? 18  LEU D CG  1 
ATOM 10110 C CD1 . LEU D 2 18  ? 17.576  45.451  -2.896  1.00 93.55  ? 18  LEU D CD1 1 
ATOM 10111 C CD2 . LEU D 2 18  ? 18.695  47.567  -2.230  1.00 95.07  ? 18  LEU D CD2 1 
ATOM 10112 N N   . ARG D 2 19  ? 21.432  46.013  0.614   1.00 65.04  ? 19  ARG D N   1 
ATOM 10113 C CA  . ARG D 2 19  ? 21.726  45.426  1.907   1.00 64.00  ? 19  ARG D CA  1 
ATOM 10114 C C   . ARG D 2 19  ? 20.413  45.330  2.668   1.00 62.28  ? 19  ARG D C   1 
ATOM 10115 O O   . ARG D 2 19  ? 19.801  46.347  2.993   1.00 59.66  ? 19  ARG D O   1 
ATOM 10116 C CB  . ARG D 2 19  ? 22.788  46.224  2.665   1.00 66.07  ? 19  ARG D CB  1 
ATOM 10117 C CG  . ARG D 2 19  ? 23.220  45.681  4.020   1.00 68.36  ? 19  ARG D CG  1 
ATOM 10118 C CD  . ARG D 2 19  ? 23.359  46.853  4.995   1.00 81.35  ? 19  ARG D CD  1 
ATOM 10119 N NE  . ARG D 2 19  ? 24.209  46.608  6.166   1.00 89.71  ? 19  ARG D NE  1 
ATOM 10120 C CZ  . ARG D 2 19  ? 24.532  47.523  7.090   1.00 96.67  ? 19  ARG D CZ  1 
ATOM 10121 N NH1 . ARG D 2 19  ? 23.971  48.727  7.097   1.00 89.24  ? 19  ARG D NH1 1 
ATOM 10122 N NH2 . ARG D 2 19  ? 25.419  47.214  8.023   1.00 102.88 ? 19  ARG D NH2 1 
ATOM 10123 N N   . LEU D 2 20  ? 19.986  44.087  2.898   1.00 62.16  ? 20  LEU D N   1 
ATOM 10124 C CA  . LEU D 2 20  ? 18.794  43.809  3.677   1.00 64.05  ? 20  LEU D CA  1 
ATOM 10125 C C   . LEU D 2 20  ? 19.138  43.884  5.159   1.00 59.80  ? 20  LEU D C   1 
ATOM 10126 O O   . LEU D 2 20  ? 20.296  43.710  5.543   1.00 62.95  ? 20  LEU D O   1 
ATOM 10127 C CB  . LEU D 2 20  ? 18.216  42.451  3.277   1.00 68.54  ? 20  LEU D CB  1 
ATOM 10128 C CG  . LEU D 2 20  ? 17.191  42.493  2.139   1.00 71.79  ? 20  LEU D CG  1 
ATOM 10129 C CD1 . LEU D 2 20  ? 17.700  43.310  0.955   1.00 76.00  ? 20  LEU D CD1 1 
ATOM 10130 C CD2 . LEU D 2 20  ? 16.823  41.088  1.714   1.00 72.93  ? 20  LEU D CD2 1 
ATOM 10131 N N   . SER D 2 21  ? 18.118  44.183  5.971   1.00 55.51  ? 21  SER D N   1 
ATOM 10132 C CA  . SER D 2 21  ? 18.272  44.291  7.409   1.00 58.62  ? 21  SER D CA  1 
ATOM 10133 C C   . SER D 2 21  ? 17.033  43.716  8.066   1.00 57.91  ? 21  SER D C   1 
ATOM 10134 O O   . SER D 2 21  ? 15.925  43.962  7.596   1.00 55.24  ? 21  SER D O   1 
ATOM 10135 C CB  . SER D 2 21  ? 18.487  45.713  7.844   1.00 66.41  ? 21  SER D CB  1 
ATOM 10136 O OG  . SER D 2 21  ? 19.529  46.326  7.092   1.00 77.90  ? 21  SER D OG  1 
ATOM 10137 N N   . CYS D 2 22  ? 17.250  42.956  9.145   1.00 63.47  ? 22  CYS D N   1 
ATOM 10138 C CA  . CYS D 2 22  ? 16.158  42.355  9.892   1.00 68.25  ? 22  CYS D CA  1 
ATOM 10139 C C   . CYS D 2 22  ? 16.298  42.633  11.384  1.00 67.99  ? 22  CYS D C   1 
ATOM 10140 O O   . CYS D 2 22  ? 17.284  42.221  11.987  1.00 78.16  ? 22  CYS D O   1 
ATOM 10141 C CB  . CYS D 2 22  ? 16.105  40.847  9.712   1.00 70.69  ? 22  CYS D CB  1 
ATOM 10142 S SG  . CYS D 2 22  ? 14.980  40.081  10.901  1.00 81.24  ? 22  CYS D SG  1 
ATOM 10143 N N   . THR D 2 23  ? 15.282  43.290  11.967  1.00 70.61  ? 23  THR D N   1 
ATOM 10144 C CA  . THR D 2 23  ? 15.313  43.710  13.361  1.00 77.41  ? 23  THR D CA  1 
ATOM 10145 C C   . THR D 2 23  ? 14.523  42.701  14.183  1.00 78.32  ? 23  THR D C   1 
ATOM 10146 O O   . THR D 2 23  ? 13.334  42.522  13.925  1.00 75.50  ? 23  THR D O   1 
ATOM 10147 C CB  . THR D 2 23  ? 14.723  45.109  13.551  1.00 76.74  ? 23  THR D CB  1 
ATOM 10148 O OG1 . THR D 2 23  ? 15.179  45.950  12.498  1.00 75.48  ? 23  THR D OG1 1 
ATOM 10149 C CG2 . THR D 2 23  ? 15.123  45.717  14.885  1.00 77.99  ? 23  THR D CG2 1 
ATOM 10150 N N   . ALA D 2 24  ? 15.191  42.101  15.186  1.00 82.30  ? 24  ALA D N   1 
ATOM 10151 C CA  . ALA D 2 24  ? 14.608  41.064  16.026  1.00 81.35  ? 24  ALA D CA  1 
ATOM 10152 C C   . ALA D 2 24  ? 14.294  41.596  17.430  1.00 75.71  ? 24  ALA D C   1 
ATOM 10153 O O   . ALA D 2 24  ? 15.197  41.993  18.162  1.00 68.71  ? 24  ALA D O   1 
ATOM 10154 C CB  . ALA D 2 24  ? 15.554  39.882  16.076  1.00 86.91  ? 24  ALA D CB  1 
ATOM 10155 N N   . SER D 2 25  ? 12.998  41.598  17.785  1.00 73.97  ? 25  SER D N   1 
ATOM 10156 C CA  . SER D 2 25  ? 12.514  41.917  19.123  1.00 71.20  ? 25  SER D CA  1 
ATOM 10157 C C   . SER D 2 25  ? 12.174  40.629  19.860  1.00 68.10  ? 25  SER D C   1 
ATOM 10158 O O   . SER D 2 25  ? 12.227  39.547  19.283  1.00 78.14  ? 25  SER D O   1 
ATOM 10159 C CB  . SER D 2 25  ? 11.285  42.796  19.109  1.00 74.13  ? 25  SER D CB  1 
ATOM 10160 O OG  . SER D 2 25  ? 11.441  43.889  18.220  1.00 91.90  ? 25  SER D OG  1 
ATOM 10161 N N   . GLY D 2 26  ? 11.808  40.773  21.137  1.00 62.11  ? 26  GLY D N   1 
ATOM 10162 C CA  . GLY D 2 26  ? 11.390  39.650  21.957  1.00 60.87  ? 26  GLY D CA  1 
ATOM 10163 C C   . GLY D 2 26  ? 12.477  39.198  22.931  1.00 55.94  ? 26  GLY D C   1 
ATOM 10164 O O   . GLY D 2 26  ? 13.593  39.714  22.907  1.00 59.89  ? 26  GLY D O   1 
ATOM 10165 N N   . TYR D 2 27  ? 12.120  38.226  23.780  1.00 49.62  ? 27  TYR D N   1 
ATOM 10166 C CA  . TYR D 2 27  ? 13.024  37.663  24.771  1.00 54.64  ? 27  TYR D CA  1 
ATOM 10167 C C   . TYR D 2 27  ? 14.132  36.823  24.131  1.00 60.75  ? 27  TYR D C   1 
ATOM 10168 O O   . TYR D 2 27  ? 13.841  35.799  23.508  1.00 69.26  ? 27  TYR D O   1 
ATOM 10169 C CB  . TYR D 2 27  ? 12.195  36.767  25.692  1.00 56.19  ? 27  TYR D CB  1 
ATOM 10170 C CG  . TYR D 2 27  ? 12.992  35.975  26.722  1.00 55.74  ? 27  TYR D CG  1 
ATOM 10171 C CD1 . TYR D 2 27  ? 13.625  36.622  27.774  1.00 56.09  ? 27  TYR D CD1 1 
ATOM 10172 C CD2 . TYR D 2 27  ? 13.075  34.587  26.678  1.00 54.51  ? 27  TYR D CD2 1 
ATOM 10173 C CE1 . TYR D 2 27  ? 14.338  35.926  28.734  1.00 52.19  ? 27  TYR D CE1 1 
ATOM 10174 C CE2 . TYR D 2 27  ? 13.777  33.879  27.637  1.00 53.42  ? 27  TYR D CE2 1 
ATOM 10175 C CZ  . TYR D 2 27  ? 14.409  34.550  28.669  1.00 52.03  ? 27  TYR D CZ  1 
ATOM 10176 O OH  . TYR D 2 27  ? 15.099  33.890  29.640  1.00 52.74  ? 27  TYR D OH  1 
ATOM 10177 N N   . MET D 2 28  ? 15.397  37.241  24.326  1.00 54.04  ? 28  MET D N   1 
ATOM 10178 C CA  . MET D 2 28  ? 16.561  36.468  23.922  1.00 47.58  ? 28  MET D CA  1 
ATOM 10179 C C   . MET D 2 28  ? 16.603  36.306  22.395  1.00 50.89  ? 28  MET D C   1 
ATOM 10180 O O   . MET D 2 28  ? 16.743  35.198  21.881  1.00 51.90  ? 28  MET D O   1 
ATOM 10181 C CB  . MET D 2 28  ? 16.537  35.112  24.636  1.00 46.19  ? 28  MET D CB  1 
ATOM 10182 C CG  . MET D 2 28  ? 16.696  35.188  26.146  1.00 46.36  ? 28  MET D CG  1 
ATOM 10183 S SD  . MET D 2 28  ? 18.420  35.264  26.688  1.00 46.30  ? 28  MET D SD  1 
ATOM 10184 C CE  . MET D 2 28  ? 18.224  35.167  28.474  1.00 45.91  ? 28  MET D CE  1 
ATOM 10185 N N   . SER D 2 29  ? 16.521  37.429  21.661  1.00 52.14  ? 29  SER D N   1 
ATOM 10186 C CA  . SER D 2 29  ? 16.465  37.430  20.203  1.00 50.24  ? 29  SER D CA  1 
ATOM 10187 C C   . SER D 2 29  ? 17.850  37.297  19.578  1.00 54.46  ? 29  SER D C   1 
ATOM 10188 O O   . SER D 2 29  ? 17.965  36.983  18.393  1.00 54.17  ? 29  SER D O   1 
ATOM 10189 C CB  . SER D 2 29  ? 15.829  38.680  19.714  1.00 51.85  ? 29  SER D CB  1 
ATOM 10190 O OG  . SER D 2 29  ? 14.833  39.103  20.628  1.00 60.84  ? 29  SER D OG  1 
ATOM 10191 N N   . SER D 2 30  ? 18.889  37.560  20.380  1.00 59.80  ? 30  SER D N   1 
ATOM 10192 C CA  . SER D 2 30  ? 20.276  37.482  19.945  1.00 65.78  ? 30  SER D CA  1 
ATOM 10193 C C   . SER D 2 30  ? 20.842  36.068  20.094  1.00 64.08  ? 30  SER D C   1 
ATOM 10194 O O   . SER D 2 30  ? 22.057  35.862  19.985  1.00 58.55  ? 30  SER D O   1 
ATOM 10195 C CB  . SER D 2 30  ? 21.110  38.446  20.730  1.00 69.94  ? 30  SER D CB  1 
ATOM 10196 O OG  . SER D 2 30  ? 20.462  39.706  20.782  1.00 84.88  ? 30  SER D OG  1 
ATOM 10197 N N   . THR D 2 31  ? 19.964  35.092  20.343  1.00 60.39  ? 31  THR D N   1 
ATOM 10198 C CA  . THR D 2 31  ? 20.415  33.750  20.663  1.00 56.91  ? 31  THR D CA  1 
ATOM 10199 C C   . THR D 2 31  ? 20.059  32.749  19.566  1.00 55.91  ? 31  THR D C   1 
ATOM 10200 O O   . THR D 2 31  ? 20.544  31.622  19.603  1.00 65.80  ? 31  THR D O   1 
ATOM 10201 C CB  . THR D 2 31  ? 19.789  33.356  21.994  1.00 52.23  ? 31  THR D CB  1 
ATOM 10202 O OG1 . THR D 2 31  ? 18.554  32.708  21.685  1.00 51.45  ? 31  THR D OG1 1 
ATOM 10203 C CG2 . THR D 2 31  ? 19.698  34.564  22.908  1.00 49.19  ? 31  THR D CG2 1 
ATOM 10204 N N   . TYR D 2 32  ? 19.202  33.131  18.613  1.00 50.94  ? 32  TYR D N   1 
ATOM 10205 C CA  . TYR D 2 32  ? 18.679  32.159  17.669  1.00 51.83  ? 32  TYR D CA  1 
ATOM 10206 C C   . TYR D 2 32  ? 19.686  31.931  16.549  1.00 48.83  ? 32  TYR D C   1 
ATOM 10207 O O   . TYR D 2 32  ? 20.525  32.783  16.268  1.00 46.11  ? 32  TYR D O   1 
ATOM 10208 C CB  . TYR D 2 32  ? 17.327  32.586  17.101  1.00 52.96  ? 32  TYR D CB  1 
ATOM 10209 C CG  . TYR D 2 32  ? 16.183  32.575  18.103  1.00 60.91  ? 32  TYR D CG  1 
ATOM 10210 C CD1 . TYR D 2 32  ? 16.377  32.350  19.457  1.00 64.61  ? 32  TYR D CD1 1 
ATOM 10211 C CD2 . TYR D 2 32  ? 14.889  32.837  17.685  1.00 71.63  ? 32  TYR D CD2 1 
ATOM 10212 C CE1 . TYR D 2 32  ? 15.313  32.367  20.343  1.00 65.75  ? 32  TYR D CE1 1 
ATOM 10213 C CE2 . TYR D 2 32  ? 13.820  32.866  18.560  1.00 65.61  ? 32  TYR D CE2 1 
ATOM 10214 C CZ  . TYR D 2 32  ? 14.030  32.631  19.896  1.00 58.66  ? 32  TYR D CZ  1 
ATOM 10215 O OH  . TYR D 2 32  ? 12.908  32.671  20.662  1.00 52.81  ? 32  TYR D OH  1 
ATOM 10216 N N   . TYR D 2 33  ? 19.616  30.734  15.961  1.00 49.03  ? 33  TYR D N   1 
ATOM 10217 C CA  . TYR D 2 33  ? 20.101  30.523  14.612  1.00 53.08  ? 33  TYR D CA  1 
ATOM 10218 C C   . TYR D 2 33  ? 19.132  31.297  13.708  1.00 55.92  ? 33  TYR D C   1 
ATOM 10219 O O   . TYR D 2 33  ? 17.912  31.236  13.896  1.00 48.92  ? 33  TYR D O   1 
ATOM 10220 C CB  . TYR D 2 33  ? 20.237  29.009  14.354  1.00 51.51  ? 33  TYR D CB  1 
ATOM 10221 C CG  . TYR D 2 33  ? 21.337  28.280  15.122  1.00 48.23  ? 33  TYR D CG  1 
ATOM 10222 C CD1 . TYR D 2 33  ? 21.163  27.907  16.452  1.00 50.11  ? 33  TYR D CD1 1 
ATOM 10223 C CD2 . TYR D 2 33  ? 22.538  27.929  14.510  1.00 45.64  ? 33  TYR D CD2 1 
ATOM 10224 C CE1 . TYR D 2 33  ? 22.158  27.234  17.152  1.00 53.94  ? 33  TYR D CE1 1 
ATOM 10225 C CE2 . TYR D 2 33  ? 23.547  27.274  15.203  1.00 49.47  ? 33  TYR D CE2 1 
ATOM 10226 C CZ  . TYR D 2 33  ? 23.368  26.921  16.537  1.00 55.08  ? 33  TYR D CZ  1 
ATOM 10227 O OH  . TYR D 2 33  ? 24.384  26.279  17.238  1.00 48.69  ? 33  TYR D OH  1 
ATOM 10228 N N   . MET D 2 34  ? 19.672  32.083  12.769  1.00 58.92  ? 34  MET D N   1 
ATOM 10229 C CA  . MET D 2 34  ? 18.836  32.934  11.937  1.00 59.22  ? 34  MET D CA  1 
ATOM 10230 C C   . MET D 2 34  ? 19.187  32.683  10.480  1.00 53.64  ? 34  MET D C   1 
ATOM 10231 O O   . MET D 2 34  ? 20.294  32.232  10.180  1.00 45.65  ? 34  MET D O   1 
ATOM 10232 C CB  . MET D 2 34  ? 18.980  34.417  12.309  1.00 65.20  ? 34  MET D CB  1 
ATOM 10233 C CG  . MET D 2 34  ? 17.910  34.889  13.282  1.00 69.80  ? 34  MET D CG  1 
ATOM 10234 S SD  . MET D 2 34  ? 17.937  36.642  13.707  1.00 81.95  ? 34  MET D SD  1 
ATOM 10235 C CE  . MET D 2 34  ? 19.526  36.637  14.539  1.00 77.88  ? 34  MET D CE  1 
ATOM 10236 N N   . ALA D 2 35  ? 18.207  32.937  9.604   1.00 53.02  ? 35  ALA D N   1 
ATOM 10237 C CA  . ALA D 2 35  ? 18.327  32.548  8.206   1.00 60.74  ? 35  ALA D CA  1 
ATOM 10238 C C   . ALA D 2 35  ? 17.653  33.575  7.320   1.00 60.46  ? 35  ALA D C   1 
ATOM 10239 O O   . ALA D 2 35  ? 16.665  34.181  7.732   1.00 60.63  ? 35  ALA D O   1 
ATOM 10240 C CB  . ALA D 2 35  ? 17.714  31.190  7.948   1.00 61.38  ? 35  ALA D CB  1 
ATOM 10241 N N   . TRP D 2 36  ? 18.213  33.722  6.113   1.00 59.61  ? 36  TRP D N   1 
ATOM 10242 C CA  . TRP D 2 36  ? 17.540  34.391  5.018   1.00 59.30  ? 36  TRP D CA  1 
ATOM 10243 C C   . TRP D 2 36  ? 16.961  33.358  4.061   1.00 57.73  ? 36  TRP D C   1 
ATOM 10244 O O   . TRP D 2 36  ? 17.598  32.342  3.776   1.00 48.70  ? 36  TRP D O   1 
ATOM 10245 C CB  . TRP D 2 36  ? 18.496  35.337  4.295   1.00 57.70  ? 36  TRP D CB  1 
ATOM 10246 C CG  . TRP D 2 36  ? 18.729  36.607  5.059   1.00 54.01  ? 36  TRP D CG  1 
ATOM 10247 C CD1 . TRP D 2 36  ? 19.841  36.982  5.749   1.00 56.17  ? 36  TRP D CD1 1 
ATOM 10248 C CD2 . TRP D 2 36  ? 17.780  37.670  5.216   1.00 54.22  ? 36  TRP D CD2 1 
ATOM 10249 N NE1 . TRP D 2 36  ? 19.666  38.219  6.306   1.00 55.72  ? 36  TRP D NE1 1 
ATOM 10250 C CE2 . TRP D 2 36  ? 18.409  38.662  6.001   1.00 56.80  ? 36  TRP D CE2 1 
ATOM 10251 C CE3 . TRP D 2 36  ? 16.474  37.873  4.762   1.00 55.43  ? 36  TRP D CE3 1 
ATOM 10252 C CZ2 . TRP D 2 36  ? 17.767  39.844  6.347   1.00 61.86  ? 36  TRP D CZ2 1 
ATOM 10253 C CZ3 . TRP D 2 36  ? 15.839  39.045  5.103   1.00 59.66  ? 36  TRP D CZ3 1 
ATOM 10254 C CH2 . TRP D 2 36  ? 16.476  40.010  5.889   1.00 65.51  ? 36  TRP D CH2 1 
ATOM 10255 N N   . PHE D 2 37  ? 15.727  33.650  3.628   1.00 58.29  ? 37  PHE D N   1 
ATOM 10256 C CA  . PHE D 2 37  ? 14.966  32.832  2.705   1.00 60.24  ? 37  PHE D CA  1 
ATOM 10257 C C   . PHE D 2 37  ? 14.294  33.767  1.713   1.00 61.51  ? 37  PHE D C   1 
ATOM 10258 O O   . PHE D 2 37  ? 13.722  34.767  2.126   1.00 64.20  ? 37  PHE D O   1 
ATOM 10259 C CB  . PHE D 2 37  ? 13.855  32.037  3.399   1.00 59.16  ? 37  PHE D CB  1 
ATOM 10260 C CG  . PHE D 2 37  ? 14.312  30.837  4.215   1.00 68.75  ? 37  PHE D CG  1 
ATOM 10261 C CD1 . PHE D 2 37  ? 14.808  30.988  5.505   1.00 71.38  ? 37  PHE D CD1 1 
ATOM 10262 C CD2 . PHE D 2 37  ? 14.220  29.550  3.694   1.00 78.17  ? 37  PHE D CD2 1 
ATOM 10263 C CE1 . PHE D 2 37  ? 15.212  29.886  6.242   1.00 71.39  ? 37  PHE D CE1 1 
ATOM 10264 C CE2 . PHE D 2 37  ? 14.621  28.449  4.438   1.00 76.18  ? 37  PHE D CE2 1 
ATOM 10265 C CZ  . PHE D 2 37  ? 15.115  28.621  5.710   1.00 75.49  ? 37  PHE D CZ  1 
ATOM 10266 N N   . ARG D 2 38  ? 14.316  33.416  0.423   1.00 61.36  ? 38  ARG D N   1 
ATOM 10267 C CA  . ARG D 2 38  ? 13.591  34.187  -0.572  1.00 55.54  ? 38  ARG D CA  1 
ATOM 10268 C C   . ARG D 2 38  ? 12.406  33.396  -1.108  1.00 48.31  ? 38  ARG D C   1 
ATOM 10269 O O   . ARG D 2 38  ? 12.336  32.184  -0.988  1.00 44.00  ? 38  ARG D O   1 
ATOM 10270 C CB  . ARG D 2 38  ? 14.551  34.641  -1.672  1.00 58.66  ? 38  ARG D CB  1 
ATOM 10271 C CG  . ARG D 2 38  ? 15.168  33.613  -2.608  1.00 61.23  ? 38  ARG D CG  1 
ATOM 10272 C CD  . ARG D 2 38  ? 16.197  34.347  -3.486  1.00 65.01  ? 38  ARG D CD  1 
ATOM 10273 N NE  . ARG D 2 38  ? 16.919  33.555  -4.490  1.00 62.59  ? 38  ARG D NE  1 
ATOM 10274 C CZ  . ARG D 2 38  ? 18.089  33.910  -5.033  1.00 67.45  ? 38  ARG D CZ  1 
ATOM 10275 N NH1 . ARG D 2 38  ? 18.646  35.086  -4.782  1.00 62.04  ? 38  ARG D NH1 1 
ATOM 10276 N NH2 . ARG D 2 38  ? 18.722  33.070  -5.835  1.00 80.54  ? 38  ARG D NH2 1 
ATOM 10277 N N   . GLN D 2 39  ? 11.442  34.101  -1.676  1.00 51.12  ? 39  GLN D N   1 
ATOM 10278 C CA  . GLN D 2 39  ? 10.450  33.418  -2.478  1.00 61.25  ? 39  GLN D CA  1 
ATOM 10279 C C   . GLN D 2 39  ? 10.432  34.026  -3.879  1.00 71.94  ? 39  GLN D C   1 
ATOM 10280 O O   . GLN D 2 39  ? 9.853   35.095  -4.085  1.00 75.15  ? 39  GLN D O   1 
ATOM 10281 C CB  . GLN D 2 39  ? 9.070   33.428  -1.835  1.00 59.25  ? 39  GLN D CB  1 
ATOM 10282 C CG  . GLN D 2 39  ? 8.209   32.300  -2.384  1.00 61.58  ? 39  GLN D CG  1 
ATOM 10283 C CD  . GLN D 2 39  ? 6.734   32.601  -2.338  1.00 65.53  ? 39  GLN D CD  1 
ATOM 10284 O OE1 . GLN D 2 39  ? 6.104   32.522  -1.287  1.00 76.12  ? 39  GLN D OE1 1 
ATOM 10285 N NE2 . GLN D 2 39  ? 6.159   32.937  -3.482  1.00 77.11  ? 39  GLN D NE2 1 
ATOM 10286 N N   . PRO D 2 40  ? 11.100  33.383  -4.873  1.00 68.52  ? 40  PRO D N   1 
ATOM 10287 C CA  . PRO D 2 40  ? 11.020  33.812  -6.267  1.00 62.72  ? 40  PRO D CA  1 
ATOM 10288 C C   . PRO D 2 40  ? 9.590   33.647  -6.756  1.00 65.22  ? 40  PRO D C   1 
ATOM 10289 O O   . PRO D 2 40  ? 8.917   32.713  -6.330  1.00 63.80  ? 40  PRO D O   1 
ATOM 10290 C CB  . PRO D 2 40  ? 11.986  32.896  -7.019  1.00 65.33  ? 40  PRO D CB  1 
ATOM 10291 C CG  . PRO D 2 40  ? 12.897  32.346  -5.951  1.00 70.19  ? 40  PRO D CG  1 
ATOM 10292 C CD  . PRO D 2 40  ? 12.022  32.250  -4.703  1.00 72.27  ? 40  PRO D CD  1 
ATOM 10293 N N   . PRO D 2 41  ? 9.106   34.524  -7.668  1.00 67.70  ? 41  PRO D N   1 
ATOM 10294 C CA  . PRO D 2 41  ? 7.685   34.558  -8.023  1.00 68.56  ? 41  PRO D CA  1 
ATOM 10295 C C   . PRO D 2 41  ? 7.177   33.219  -8.557  1.00 72.81  ? 41  PRO D C   1 
ATOM 10296 O O   . PRO D 2 41  ? 7.869   32.574  -9.343  1.00 60.39  ? 41  PRO D O   1 
ATOM 10297 C CB  . PRO D 2 41  ? 7.621   35.682  -9.074  1.00 71.95  ? 41  PRO D CB  1 
ATOM 10298 C CG  . PRO D 2 41  ? 8.856   36.538  -8.810  1.00 69.55  ? 41  PRO D CG  1 
ATOM 10299 C CD  . PRO D 2 41  ? 9.904   35.531  -8.391  1.00 65.49  ? 41  PRO D CD  1 
ATOM 10300 N N   . GLY D 2 42  ? 5.991   32.802  -8.072  1.00 83.54  ? 42  GLY D N   1 
ATOM 10301 C CA  . GLY D 2 42  ? 5.328   31.565  -8.476  1.00 80.17  ? 42  GLY D CA  1 
ATOM 10302 C C   . GLY D 2 42  ? 6.066   30.290  -8.046  1.00 77.33  ? 42  GLY D C   1 
ATOM 10303 O O   . GLY D 2 42  ? 5.824   29.212  -8.590  1.00 73.49  ? 42  GLY D O   1 
ATOM 10304 N N   . LYS D 2 43  ? 6.949   30.400  -7.048  1.00 76.80  ? 43  LYS D N   1 
ATOM 10305 C CA  . LYS D 2 43  ? 7.738   29.275  -6.573  1.00 75.33  ? 43  LYS D CA  1 
ATOM 10306 C C   . LYS D 2 43  ? 7.857   29.330  -5.050  1.00 81.04  ? 43  LYS D C   1 
ATOM 10307 O O   . LYS D 2 43  ? 7.598   30.366  -4.445  1.00 97.94  ? 43  LYS D O   1 
ATOM 10308 C CB  . LYS D 2 43  ? 9.148   29.334  -7.161  1.00 76.09  ? 43  LYS D CB  1 
ATOM 10309 C CG  . LYS D 2 43  ? 9.260   29.280  -8.676  1.00 77.41  ? 43  LYS D CG  1 
ATOM 10310 C CD  . LYS D 2 43  ? 10.683  28.983  -9.148  1.00 80.86  ? 43  LYS D CD  1 
ATOM 10311 C CE  . LYS D 2 43  ? 11.722  29.922  -8.587  1.00 77.29  ? 43  LYS D CE  1 
ATOM 10312 N NZ  . LYS D 2 43  ? 13.108  29.633  -8.965  1.00 75.60  ? 43  LYS D NZ  1 
ATOM 10313 N N   . GLY D 2 44  ? 8.295   28.228  -4.430  1.00 74.13  ? 44  GLY D N   1 
ATOM 10314 C CA  . GLY D 2 44  ? 8.251   28.108  -2.979  1.00 68.68  ? 44  GLY D CA  1 
ATOM 10315 C C   . GLY D 2 44  ? 9.373   28.893  -2.307  1.00 60.64  ? 44  GLY D C   1 
ATOM 10316 O O   . GLY D 2 44  ? 10.257  29.395  -2.995  1.00 62.27  ? 44  GLY D O   1 
ATOM 10317 N N   . LEU D 2 45  ? 9.319   28.981  -0.970  1.00 53.96  ? 45  LEU D N   1 
ATOM 10318 C CA  . LEU D 2 45  ? 10.445  29.445  -0.167  1.00 57.76  ? 45  LEU D CA  1 
ATOM 10319 C C   . LEU D 2 45  ? 11.689  28.604  -0.438  1.00 54.17  ? 45  LEU D C   1 
ATOM 10320 O O   . LEU D 2 45  ? 11.605  27.407  -0.690  1.00 60.42  ? 45  LEU D O   1 
ATOM 10321 C CB  . LEU D 2 45  ? 10.151  29.422  1.332   1.00 63.69  ? 45  LEU D CB  1 
ATOM 10322 C CG  . LEU D 2 45  ? 9.713   30.750  1.955   1.00 75.90  ? 45  LEU D CG  1 
ATOM 10323 C CD1 . LEU D 2 45  ? 10.652  31.879  1.551   1.00 81.16  ? 45  LEU D CD1 1 
ATOM 10324 C CD2 . LEU D 2 45  ? 8.278   31.113  1.601   1.00 80.59  ? 45  LEU D CD2 1 
ATOM 10325 N N   . GLU D 2 46  ? 12.851  29.244  -0.326  1.00 48.11  ? 46  GLU D N   1 
ATOM 10326 C CA  . GLU D 2 46  ? 14.120  28.573  -0.542  1.00 53.28  ? 46  GLU D CA  1 
ATOM 10327 C C   . GLU D 2 46  ? 15.219  29.322  0.213   1.00 56.25  ? 46  GLU D C   1 
ATOM 10328 O O   . GLU D 2 46  ? 15.182  30.539  0.365   1.00 64.34  ? 46  GLU D O   1 
ATOM 10329 C CB  . GLU D 2 46  ? 14.364  28.389  -2.041  1.00 57.70  ? 46  GLU D CB  1 
ATOM 10330 C CG  . GLU D 2 46  ? 13.651  29.407  -2.930  1.00 63.81  ? 46  GLU D CG  1 
ATOM 10331 C CD  . GLU D 2 46  ? 13.673  29.095  -4.420  1.00 72.45  ? 46  GLU D CD  1 
ATOM 10332 O OE1 . GLU D 2 46  ? 14.752  29.278  -5.028  1.00 79.52  ? 46  GLU D OE1 1 
ATOM 10333 O OE2 . GLU D 2 46  ? 12.629  28.667  -4.975  1.00 71.02  ? 46  GLU D OE2 1 
ATOM 10334 N N   . GLY D 2 47  ? 16.186  28.576  0.740   1.00 54.52  ? 47  GLY D N   1 
ATOM 10335 C CA  . GLY D 2 47  ? 17.110  29.144  1.696   1.00 54.66  ? 47  GLY D CA  1 
ATOM 10336 C C   . GLY D 2 47  ? 18.234  29.850  0.958   1.00 55.97  ? 47  GLY D C   1 
ATOM 10337 O O   . GLY D 2 47  ? 18.858  29.266  0.088   1.00 66.56  ? 47  GLY D O   1 
ATOM 10338 N N   . VAL D 2 48  ? 18.474  31.106  1.306   1.00 56.07  ? 48  VAL D N   1 
ATOM 10339 C CA  . VAL D 2 48  ? 19.573  31.842  0.722   1.00 60.39  ? 48  VAL D CA  1 
ATOM 10340 C C   . VAL D 2 48  ? 20.811  31.620  1.595   1.00 63.89  ? 48  VAL D C   1 
ATOM 10341 O O   . VAL D 2 48  ? 21.805  31.069  1.112   1.00 61.32  ? 48  VAL D O   1 
ATOM 10342 C CB  . VAL D 2 48  ? 19.144  33.319  0.589   1.00 65.43  ? 48  VAL D CB  1 
ATOM 10343 C CG1 . VAL D 2 48  ? 20.210  34.175  -0.085  1.00 64.93  ? 48  VAL D CG1 1 
ATOM 10344 C CG2 . VAL D 2 48  ? 17.804  33.456  -0.138  1.00 64.18  ? 48  VAL D CG2 1 
ATOM 10345 N N   . ALA D 2 49  ? 20.715  32.000  2.889   1.00 64.64  ? 49  ALA D N   1 
ATOM 10346 C CA  . ALA D 2 49  ? 21.877  32.093  3.773   1.00 61.17  ? 49  ALA D CA  1 
ATOM 10347 C C   . ALA D 2 49  ? 21.498  31.908  5.244   1.00 53.58  ? 49  ALA D C   1 
ATOM 10348 O O   . ALA D 2 49  ? 20.434  32.346  5.667   1.00 56.68  ? 49  ALA D O   1 
ATOM 10349 C CB  . ALA D 2 49  ? 22.584  33.421  3.564   1.00 61.03  ? 49  ALA D CB  1 
ATOM 10350 N N   . LEU D 2 50  ? 22.423  31.302  6.010   1.00 49.09  ? 50  LEU D N   1 
ATOM 10351 C CA  . LEU D 2 50  ? 22.222  30.914  7.399   1.00 49.75  ? 50  LEU D CA  1 
ATOM 10352 C C   . LEU D 2 50  ? 23.435  31.326  8.239   1.00 56.02  ? 50  LEU D C   1 
ATOM 10353 O O   . LEU D 2 50  ? 24.575  31.258  7.760   1.00 53.76  ? 50  LEU D O   1 
ATOM 10354 C CB  . LEU D 2 50  ? 22.059  29.401  7.510   1.00 50.77  ? 50  LEU D CB  1 
ATOM 10355 C CG  . LEU D 2 50  ? 21.187  28.689  6.472   1.00 50.64  ? 50  LEU D CG  1 
ATOM 10356 C CD1 . LEU D 2 50  ? 21.329  27.207  6.741   1.00 48.34  ? 50  LEU D CD1 1 
ATOM 10357 C CD2 . LEU D 2 50  ? 19.721  29.071  6.494   1.00 53.63  ? 50  LEU D CD2 1 
ATOM 10358 N N   . ILE D 2 51  ? 23.174  31.653  9.523   1.00 56.73  ? 51  ILE D N   1 
ATOM 10359 C CA  . ILE D 2 51  ? 24.150  32.257  10.428  1.00 49.71  ? 51  ILE D CA  1 
ATOM 10360 C C   . ILE D 2 51  ? 23.881  31.815  11.872  1.00 49.13  ? 51  ILE D C   1 
ATOM 10361 O O   . ILE D 2 51  ? 22.806  32.034  12.446  1.00 42.47  ? 51  ILE D O   1 
ATOM 10362 C CB  . ILE D 2 51  ? 24.143  33.795  10.289  1.00 49.05  ? 51  ILE D CB  1 
ATOM 10363 C CG1 . ILE D 2 51  ? 25.275  34.454  11.065  1.00 45.68  ? 51  ILE D CG1 1 
ATOM 10364 C CG2 . ILE D 2 51  ? 22.787  34.408  10.657  1.00 49.42  ? 51  ILE D CG2 1 
ATOM 10365 C CD1 . ILE D 2 51  ? 26.598  34.444  10.337  1.00 44.11  ? 51  ILE D CD1 1 
ATOM 10366 N N   . SER D 2 52  ? 24.910  31.209  12.468  1.00 50.52  ? 52  SER D N   1 
ATOM 10367 C CA  . SER D 2 52  ? 24.884  30.784  13.858  1.00 49.82  ? 52  SER D CA  1 
ATOM 10368 C C   . SER D 2 52  ? 24.616  31.983  14.761  1.00 58.71  ? 52  SER D C   1 
ATOM 10369 O O   . SER D 2 52  ? 24.710  33.128  14.310  1.00 62.27  ? 52  SER D O   1 
ATOM 10370 C CB  . SER D 2 52  ? 26.189  30.102  14.215  1.00 49.16  ? 52  SER D CB  1 
ATOM 10371 O OG  . SER D 2 52  ? 27.313  30.910  13.887  1.00 46.63  ? 52  SER D OG  1 
ATOM 10372 N N   . PRO D 2 53  ? 24.294  31.764  16.061  1.00 62.96  ? 53  PRO D N   1 
ATOM 10373 C CA  . PRO D 2 53  ? 24.005  32.864  16.987  1.00 60.39  ? 53  PRO D CA  1 
ATOM 10374 C C   . PRO D 2 53  ? 25.084  33.940  17.014  1.00 58.31  ? 53  PRO D C   1 
ATOM 10375 O O   . PRO D 2 53  ? 24.768  35.126  17.090  1.00 62.07  ? 53  PRO D O   1 
ATOM 10376 C CB  . PRO D 2 53  ? 23.861  32.183  18.359  1.00 61.31  ? 53  PRO D CB  1 
ATOM 10377 C CG  . PRO D 2 53  ? 23.474  30.762  18.028  1.00 62.29  ? 53  PRO D CG  1 
ATOM 10378 C CD  . PRO D 2 53  ? 24.157  30.449  16.705  1.00 61.44  ? 53  PRO D CD  1 
ATOM 10379 N N   . TYR D 2 54  ? 26.353  33.521  16.964  1.00 57.36  ? 54  TYR D N   1 
ATOM 10380 C CA  . TYR D 2 54  ? 27.447  34.471  17.092  1.00 60.92  ? 54  TYR D CA  1 
ATOM 10381 C C   . TYR D 2 54  ? 28.218  34.609  15.773  1.00 59.62  ? 54  TYR D C   1 
ATOM 10382 O O   . TYR D 2 54  ? 29.366  35.062  15.765  1.00 54.78  ? 54  TYR D O   1 
ATOM 10383 C CB  . TYR D 2 54  ? 28.297  34.037  18.288  1.00 58.30  ? 54  TYR D CB  1 
ATOM 10384 C CG  . TYR D 2 54  ? 27.622  34.084  19.657  1.00 53.75  ? 54  TYR D CG  1 
ATOM 10385 C CD1 . TYR D 2 54  ? 27.338  35.293  20.279  1.00 51.64  ? 54  TYR D CD1 1 
ATOM 10386 C CD2 . TYR D 2 54  ? 27.348  32.920  20.367  1.00 53.29  ? 54  TYR D CD2 1 
ATOM 10387 C CE1 . TYR D 2 54  ? 26.762  35.342  21.538  1.00 50.72  ? 54  TYR D CE1 1 
ATOM 10388 C CE2 . TYR D 2 54  ? 26.786  32.957  21.632  1.00 50.99  ? 54  TYR D CE2 1 
ATOM 10389 C CZ  . TYR D 2 54  ? 26.490  34.172  22.218  1.00 49.08  ? 54  TYR D CZ  1 
ATOM 10390 O OH  . TYR D 2 54  ? 25.960  34.213  23.470  1.00 47.30  ? 54  TYR D OH  1 
ATOM 10391 N N   . GLY D 2 55  ? 27.574  34.220  14.665  1.00 57.43  ? 55  GLY D N   1 
ATOM 10392 C CA  . GLY D 2 55  ? 28.118  34.411  13.330  1.00 63.71  ? 55  GLY D CA  1 
ATOM 10393 C C   . GLY D 2 55  ? 29.460  33.713  13.073  1.00 66.15  ? 55  GLY D C   1 
ATOM 10394 O O   . GLY D 2 55  ? 30.168  34.094  12.138  1.00 59.55  ? 55  GLY D O   1 
ATOM 10395 N N   . GLY D 2 56  ? 29.788  32.684  13.872  1.00 66.92  ? 56  GLY D N   1 
ATOM 10396 C CA  . GLY D 2 56  ? 30.990  31.889  13.674  1.00 63.17  ? 56  GLY D CA  1 
ATOM 10397 C C   . GLY D 2 56  ? 30.776  30.785  12.634  1.00 61.29  ? 56  GLY D C   1 
ATOM 10398 O O   . GLY D 2 56  ? 31.725  30.073  12.293  1.00 54.64  ? 56  GLY D O   1 
ATOM 10399 N N   . ALA D 2 57  ? 29.525  30.637  12.160  1.00 56.31  ? 57  ALA D N   1 
ATOM 10400 C CA  . ALA D 2 57  ? 29.190  29.608  11.190  1.00 62.39  ? 57  ALA D CA  1 
ATOM 10401 C C   . ALA D 2 57  ? 28.071  30.078  10.261  1.00 67.01  ? 57  ALA D C   1 
ATOM 10402 O O   . ALA D 2 57  ? 26.997  30.490  10.714  1.00 58.81  ? 57  ALA D O   1 
ATOM 10403 C CB  . ALA D 2 57  ? 28.822  28.324  11.894  1.00 67.32  ? 57  ALA D CB  1 
ATOM 10404 N N   . THR D 2 58  ? 28.371  29.973  8.954   1.00 73.65  ? 58  THR D N   1 
ATOM 10405 C CA  . THR D 2 58  ? 27.579  30.508  7.856   1.00 68.96  ? 58  THR D CA  1 
ATOM 10406 C C   . THR D 2 58  ? 27.445  29.412  6.810   1.00 71.93  ? 58  THR D C   1 
ATOM 10407 O O   . THR D 2 58  ? 28.443  28.774  6.466   1.00 72.16  ? 58  THR D O   1 
ATOM 10408 C CB  . THR D 2 58  ? 28.266  31.719  7.217   1.00 62.37  ? 58  THR D CB  1 
ATOM 10409 O OG1 . THR D 2 58  ? 29.655  31.412  7.160   1.00 59.28  ? 58  THR D OG1 1 
ATOM 10410 C CG2 . THR D 2 58  ? 28.158  32.989  8.029   1.00 65.76  ? 58  THR D CG2 1 
ATOM 10411 N N   . ASN D 2 59  ? 26.222  29.220  6.304   1.00 72.43  ? 59  ASN D N   1 
ATOM 10412 C CA  . ASN D 2 59  ? 26.020  28.463  5.078   1.00 75.16  ? 59  ASN D CA  1 
ATOM 10413 C C   . ASN D 2 59  ? 25.340  29.375  4.062   1.00 75.57  ? 59  ASN D C   1 
ATOM 10414 O O   . ASN D 2 59  ? 24.684  30.340  4.458   1.00 77.52  ? 59  ASN D O   1 
ATOM 10415 C CB  . ASN D 2 59  ? 25.226  27.177  5.284   1.00 75.63  ? 59  ASN D CB  1 
ATOM 10416 C CG  . ASN D 2 59  ? 25.179  26.346  4.021   1.00 76.26  ? 59  ASN D CG  1 
ATOM 10417 O OD1 . ASN D 2 59  ? 26.226  25.962  3.485   1.00 88.14  ? 59  ASN D OD1 1 
ATOM 10418 N ND2 . ASN D 2 59  ? 23.989  26.094  3.498   1.00 77.38  ? 59  ASN D ND2 1 
ATOM 10419 N N   . TYR D 2 60  ? 25.544  29.065  2.770   1.00 66.50  ? 60  TYR D N   1 
ATOM 10420 C CA  . TYR D 2 60  ? 24.953  29.815  1.675   1.00 58.15  ? 60  TYR D CA  1 
ATOM 10421 C C   . TYR D 2 60  ? 24.475  28.825  0.632   1.00 56.18  ? 60  TYR D C   1 
ATOM 10422 O O   . TYR D 2 60  ? 25.162  27.834  0.390   1.00 56.66  ? 60  TYR D O   1 
ATOM 10423 C CB  . TYR D 2 60  ? 25.916  30.743  0.932   1.00 51.22  ? 60  TYR D CB  1 
ATOM 10424 C CG  . TYR D 2 60  ? 26.526  31.830  1.794   1.00 46.07  ? 60  TYR D CG  1 
ATOM 10425 C CD1 . TYR D 2 60  ? 25.829  33.001  2.054   1.00 46.21  ? 60  TYR D CD1 1 
ATOM 10426 C CD2 . TYR D 2 60  ? 27.793  31.673  2.356   1.00 50.09  ? 60  TYR D CD2 1 
ATOM 10427 C CE1 . TYR D 2 60  ? 26.387  34.003  2.843   1.00 50.76  ? 60  TYR D CE1 1 
ATOM 10428 C CE2 . TYR D 2 60  ? 28.357  32.661  3.154   1.00 52.22  ? 60  TYR D CE2 1 
ATOM 10429 C CZ  . TYR D 2 60  ? 27.649  33.829  3.402   1.00 50.79  ? 60  TYR D CZ  1 
ATOM 10430 O OH  . TYR D 2 60  ? 28.204  34.773  4.216   1.00 42.61  ? 60  TYR D OH  1 
ATOM 10431 N N   . ALA D 2 61  ? 23.321  29.131  0.026   1.00 56.00  ? 61  ALA D N   1 
ATOM 10432 C CA  . ALA D 2 61  ? 22.875  28.441  -1.171  1.00 54.42  ? 61  ALA D CA  1 
ATOM 10433 C C   . ALA D 2 61  ? 23.861  28.713  -2.307  1.00 60.34  ? 61  ALA D C   1 
ATOM 10434 O O   . ALA D 2 61  ? 24.365  29.826  -2.434  1.00 62.57  ? 61  ALA D O   1 
ATOM 10435 C CB  . ALA D 2 61  ? 21.477  28.879  -1.528  1.00 49.43  ? 61  ALA D CB  1 
ATOM 10436 N N   . ASP D 2 62  ? 24.109  27.683  -3.130  1.00 63.84  ? 62  ASP D N   1 
ATOM 10437 C CA  . ASP D 2 62  ? 25.045  27.737  -4.245  1.00 67.41  ? 62  ASP D CA  1 
ATOM 10438 C C   . ASP D 2 62  ? 24.735  28.907  -5.180  1.00 65.94  ? 62  ASP D C   1 
ATOM 10439 O O   . ASP D 2 62  ? 25.674  29.562  -5.637  1.00 64.43  ? 62  ASP D O   1 
ATOM 10440 C CB  . ASP D 2 62  ? 25.027  26.437  -5.037  1.00 76.08  ? 62  ASP D CB  1 
ATOM 10441 C CG  . ASP D 2 62  ? 25.677  25.220  -4.386  1.00 82.67  ? 62  ASP D CG  1 
ATOM 10442 O OD1 . ASP D 2 62  ? 26.907  25.277  -4.115  1.00 90.13  ? 62  ASP D OD1 1 
ATOM 10443 O OD2 . ASP D 2 62  ? 24.958  24.205  -4.187  1.00 78.97  ? 62  ASP D OD2 1 
ATOM 10444 N N   . SER D 2 63  ? 23.433  29.148  -5.451  1.00 59.01  ? 63  SER D N   1 
ATOM 10445 C CA  . SER D 2 63  ? 22.986  30.179  -6.380  1.00 55.94  ? 63  SER D CA  1 
ATOM 10446 C C   . SER D 2 63  ? 23.603  31.536  -6.042  1.00 56.01  ? 63  SER D C   1 
ATOM 10447 O O   . SER D 2 63  ? 23.935  32.292  -6.953  1.00 58.60  ? 63  SER D O   1 
ATOM 10448 C CB  . SER D 2 63  ? 21.473  30.271  -6.457  1.00 56.49  ? 63  SER D CB  1 
ATOM 10449 O OG  . SER D 2 63  ? 20.900  30.740  -5.248  1.00 60.28  ? 63  SER D OG  1 
ATOM 10450 N N   . VAL D 2 64  ? 23.810  31.822  -4.748  1.00 52.23  ? 64  VAL D N   1 
ATOM 10451 C CA  . VAL D 2 64  ? 24.274  33.141  -4.343  1.00 51.65  ? 64  VAL D CA  1 
ATOM 10452 C C   . VAL D 2 64  ? 25.687  33.119  -3.750  1.00 47.91  ? 64  VAL D C   1 
ATOM 10453 O O   . VAL D 2 64  ? 26.198  34.166  -3.354  1.00 44.75  ? 64  VAL D O   1 
ATOM 10454 C CB  . VAL D 2 64  ? 23.281  33.795  -3.363  1.00 50.72  ? 64  VAL D CB  1 
ATOM 10455 C CG1 . VAL D 2 64  ? 21.844  33.688  -3.863  1.00 50.86  ? 64  VAL D CG1 1 
ATOM 10456 C CG2 . VAL D 2 64  ? 23.405  33.222  -1.959  1.00 52.74  ? 64  VAL D CG2 1 
ATOM 10457 N N   . LYS D 2 65  ? 26.345  31.959  -3.694  1.00 47.72  ? 65  LYS D N   1 
ATOM 10458 C CA  . LYS D 2 65  ? 27.695  31.927  -3.152  1.00 52.92  ? 65  LYS D CA  1 
ATOM 10459 C C   . LYS D 2 65  ? 28.555  32.902  -3.944  1.00 54.45  ? 65  LYS D C   1 
ATOM 10460 O O   . LYS D 2 65  ? 28.342  33.070  -5.140  1.00 62.41  ? 65  LYS D O   1 
ATOM 10461 C CB  . LYS D 2 65  ? 28.338  30.538  -3.220  1.00 59.94  ? 65  LYS D CB  1 
ATOM 10462 C CG  . LYS D 2 65  ? 27.737  29.498  -2.287  1.00 66.16  ? 65  LYS D CG  1 
ATOM 10463 C CD  . LYS D 2 65  ? 28.446  28.153  -2.337  1.00 67.22  ? 65  LYS D CD  1 
ATOM 10464 C CE  . LYS D 2 65  ? 27.870  27.155  -1.396  1.00 67.91  ? 65  LYS D CE  1 
ATOM 10465 N NZ  . LYS D 2 65  ? 28.560  25.879  -1.581  1.00 70.86  ? 65  LYS D NZ  1 
ATOM 10466 N N   . GLY D 2 66  ? 29.504  33.555  -3.271  1.00 53.75  ? 66  GLY D N   1 
ATOM 10467 C CA  . GLY D 2 66  ? 30.453  34.428  -3.944  1.00 53.63  ? 66  GLY D CA  1 
ATOM 10468 C C   . GLY D 2 66  ? 29.895  35.826  -4.236  1.00 58.26  ? 66  GLY D C   1 
ATOM 10469 O O   . GLY D 2 66  ? 30.627  36.690  -4.724  1.00 55.55  ? 66  GLY D O   1 
ATOM 10470 N N   . ARG D 2 67  ? 28.606  36.057  -3.950  1.00 57.44  ? 67  ARG D N   1 
ATOM 10471 C CA  . ARG D 2 67  ? 27.985  37.335  -4.267  1.00 56.46  ? 67  ARG D CA  1 
ATOM 10472 C C   . ARG D 2 67  ? 27.346  37.923  -3.011  1.00 54.32  ? 67  ARG D C   1 
ATOM 10473 O O   . ARG D 2 67  ? 27.444  39.126  -2.775  1.00 51.95  ? 67  ARG D O   1 
ATOM 10474 C CB  . ARG D 2 67  ? 26.940  37.208  -5.388  1.00 54.90  ? 67  ARG D CB  1 
ATOM 10475 C CG  . ARG D 2 67  ? 27.386  36.645  -6.733  1.00 48.56  ? 67  ARG D CG  1 
ATOM 10476 C CD  . ARG D 2 67  ? 26.231  36.642  -7.738  1.00 47.56  ? 67  ARG D CD  1 
ATOM 10477 N NE  . ARG D 2 67  ? 25.010  35.931  -7.322  1.00 46.92  ? 67  ARG D NE  1 
ATOM 10478 C CZ  . ARG D 2 67  ? 23.742  36.355  -7.443  1.00 44.48  ? 67  ARG D CZ  1 
ATOM 10479 N NH1 . ARG D 2 67  ? 22.732  35.517  -7.422  1.00 47.67  ? 67  ARG D NH1 1 
ATOM 10480 N NH2 . ARG D 2 67  ? 23.450  37.599  -7.708  1.00 44.93  ? 67  ARG D NH2 1 
ATOM 10481 N N   . PHE D 2 68  ? 26.648  37.067  -2.251  1.00 54.04  ? 68  PHE D N   1 
ATOM 10482 C CA  . PHE D 2 68  ? 25.961  37.470  -1.033  1.00 52.82  ? 68  PHE D CA  1 
ATOM 10483 C C   . PHE D 2 68  ? 26.882  37.177  0.147   1.00 52.23  ? 68  PHE D C   1 
ATOM 10484 O O   . PHE D 2 68  ? 27.674  36.231  0.091   1.00 51.45  ? 68  PHE D O   1 
ATOM 10485 C CB  . PHE D 2 68  ? 24.613  36.761  -0.832  1.00 48.38  ? 68  PHE D CB  1 
ATOM 10486 C CG  . PHE D 2 68  ? 23.516  37.078  -1.840  1.00 49.26  ? 68  PHE D CG  1 
ATOM 10487 C CD1 . PHE D 2 68  ? 23.777  37.759  -3.025  1.00 48.64  ? 68  PHE D CD1 1 
ATOM 10488 C CD2 . PHE D 2 68  ? 22.206  36.670  -1.599  1.00 53.30  ? 68  PHE D CD2 1 
ATOM 10489 C CE1 . PHE D 2 68  ? 22.755  38.015  -3.929  1.00 54.89  ? 68  PHE D CE1 1 
ATOM 10490 C CE2 . PHE D 2 68  ? 21.180  36.942  -2.504  1.00 51.38  ? 68  PHE D CE2 1 
ATOM 10491 C CZ  . PHE D 2 68  ? 21.457  37.601  -3.671  1.00 53.69  ? 68  PHE D CZ  1 
ATOM 10492 N N   . THR D 2 69  ? 26.780  38.026  1.181   1.00 52.23  ? 69  THR D N   1 
ATOM 10493 C CA  . THR D 2 69  ? 27.328  37.750  2.502   1.00 55.52  ? 69  THR D CA  1 
ATOM 10494 C C   . THR D 2 69  ? 26.210  37.953  3.526   1.00 64.74  ? 69  THR D C   1 
ATOM 10495 O O   . THR D 2 69  ? 25.449  38.913  3.390   1.00 62.65  ? 69  THR D O   1 
ATOM 10496 C CB  . THR D 2 69  ? 28.523  38.663  2.790   1.00 50.83  ? 69  THR D CB  1 
ATOM 10497 O OG1 . THR D 2 69  ? 29.549  38.381  1.838   1.00 48.25  ? 69  THR D OG1 1 
ATOM 10498 C CG2 . THR D 2 69  ? 29.085  38.467  4.190   1.00 48.57  ? 69  THR D CG2 1 
ATOM 10499 N N   . ILE D 2 70  ? 26.119  37.046  4.526   1.00 74.35  ? 70  ILE D N   1 
ATOM 10500 C CA  . ILE D 2 70  ? 25.181  37.167  5.646   1.00 77.58  ? 70  ILE D CA  1 
ATOM 10501 C C   . ILE D 2 70  ? 25.940  37.616  6.895   1.00 72.36  ? 70  ILE D C   1 
ATOM 10502 O O   . ILE D 2 70  ? 27.068  37.181  7.131   1.00 75.47  ? 70  ILE D O   1 
ATOM 10503 C CB  . ILE D 2 70  ? 24.403  35.860  5.928   1.00 71.72  ? 70  ILE D CB  1 
ATOM 10504 C CG1 . ILE D 2 70  ? 23.181  36.123  6.819   1.00 64.41  ? 70  ILE D CG1 1 
ATOM 10505 C CG2 . ILE D 2 70  ? 25.307  34.779  6.534   1.00 69.32  ? 70  ILE D CG2 1 
ATOM 10506 C CD1 . ILE D 2 70  ? 22.264  34.924  6.981   1.00 60.31  ? 70  ILE D CD1 1 
ATOM 10507 N N   . SER D 2 71  ? 25.290  38.448  7.717   1.00 68.36  ? 71  SER D N   1 
ATOM 10508 C CA  . SER D 2 71  ? 25.947  39.017  8.882   1.00 67.09  ? 71  SER D CA  1 
ATOM 10509 C C   . SER D 2 71  ? 24.960  39.327  10.008  1.00 61.04  ? 71  SER D C   1 
ATOM 10510 O O   . SER D 2 71  ? 23.765  39.532  9.790   1.00 54.73  ? 71  SER D O   1 
ATOM 10511 C CB  . SER D 2 71  ? 26.700  40.250  8.481   1.00 65.59  ? 71  SER D CB  1 
ATOM 10512 O OG  . SER D 2 71  ? 27.653  40.568  9.481   1.00 70.57  ? 71  SER D OG  1 
ATOM 10513 N N   . ARG D 2 72  ? 25.483  39.423  11.229  1.00 59.16  ? 72  ARG D N   1 
ATOM 10514 C CA  . ARG D 2 72  ? 24.639  39.825  12.342  1.00 65.56  ? 72  ARG D CA  1 
ATOM 10515 C C   . ARG D 2 72  ? 25.371  40.790  13.277  1.00 67.85  ? 72  ARG D C   1 
ATOM 10516 O O   . ARG D 2 72  ? 26.581  40.687  13.474  1.00 73.49  ? 72  ARG D O   1 
ATOM 10517 C CB  . ARG D 2 72  ? 24.129  38.563  13.051  1.00 66.54  ? 72  ARG D CB  1 
ATOM 10518 C CG  . ARG D 2 72  ? 25.162  37.704  13.771  1.00 59.73  ? 72  ARG D CG  1 
ATOM 10519 C CD  . ARG D 2 72  ? 24.529  36.411  14.249  1.00 58.07  ? 72  ARG D CD  1 
ATOM 10520 N NE  . ARG D 2 72  ? 23.343  36.608  15.098  1.00 58.77  ? 72  ARG D NE  1 
ATOM 10521 C CZ  . ARG D 2 72  ? 22.343  35.737  15.308  1.00 56.70  ? 72  ARG D CZ  1 
ATOM 10522 N NH1 . ARG D 2 72  ? 22.175  34.665  14.550  1.00 53.29  ? 72  ARG D NH1 1 
ATOM 10523 N NH2 . ARG D 2 72  ? 21.468  35.967  16.274  1.00 58.43  ? 72  ARG D NH2 1 
ATOM 10524 N N   . ASP D 2 73  ? 24.597  41.718  13.856  1.00 67.99  ? 73  ASP D N   1 
ATOM 10525 C CA  . ASP D 2 73  ? 25.041  42.562  14.952  1.00 72.37  ? 73  ASP D CA  1 
ATOM 10526 C C   . ASP D 2 73  ? 24.089  42.319  16.128  1.00 76.33  ? 73  ASP D C   1 
ATOM 10527 O O   . ASP D 2 73  ? 22.924  42.722  16.085  1.00 73.76  ? 73  ASP D O   1 
ATOM 10528 C CB  . ASP D 2 73  ? 25.127  44.003  14.470  1.00 75.09  ? 73  ASP D CB  1 
ATOM 10529 C CG  . ASP D 2 73  ? 25.586  45.040  15.486  1.00 79.05  ? 73  ASP D CG  1 
ATOM 10530 O OD1 . ASP D 2 73  ? 26.074  44.638  16.570  1.00 80.54  ? 73  ASP D OD1 1 
ATOM 10531 O OD2 . ASP D 2 73  ? 25.439  46.248  15.187  1.00 77.99  ? 73  ASP D OD2 1 
ATOM 10532 N N   . ASN D 2 74  ? 24.575  41.618  17.165  1.00 77.67  ? 74  ASN D N   1 
ATOM 10533 C CA  . ASN D 2 74  ? 23.707  41.168  18.248  1.00 82.99  ? 74  ASN D CA  1 
ATOM 10534 C C   . ASN D 2 74  ? 23.363  42.338  19.172  1.00 79.05  ? 74  ASN D C   1 
ATOM 10535 O O   . ASN D 2 74  ? 22.275  42.369  19.747  1.00 62.96  ? 74  ASN D O   1 
ATOM 10536 C CB  . ASN D 2 74  ? 24.287  39.966  18.997  1.00 82.11  ? 74  ASN D CB  1 
ATOM 10537 C CG  . ASN D 2 74  ? 24.145  38.662  18.234  1.00 74.19  ? 74  ASN D CG  1 
ATOM 10538 O OD1 . ASN D 2 74  ? 23.694  38.651  17.082  1.00 67.39  ? 74  ASN D OD1 1 
ATOM 10539 N ND2 . ASN D 2 74  ? 24.513  37.548  18.854  1.00 67.21  ? 74  ASN D ND2 1 
ATOM 10540 N N   . ALA D 2 75  ? 24.288  43.304  19.291  1.00 89.34  ? 75  ALA D N   1 
ATOM 10541 C CA  . ALA D 2 75  ? 24.068  44.501  20.095  1.00 84.30  ? 75  ALA D CA  1 
ATOM 10542 C C   . ALA D 2 75  ? 22.883  45.292  19.533  1.00 77.12  ? 75  ALA D C   1 
ATOM 10543 O O   . ALA D 2 75  ? 21.997  45.719  20.270  1.00 72.78  ? 75  ALA D O   1 
ATOM 10544 C CB  . ALA D 2 75  ? 25.340  45.329  20.155  1.00 77.82  ? 75  ALA D CB  1 
ATOM 10545 N N   . LYS D 2 76  ? 22.834  45.443  18.210  1.00 68.69  ? 76  LYS D N   1 
ATOM 10546 C CA  . LYS D 2 76  ? 21.721  46.128  17.587  1.00 70.82  ? 76  LYS D CA  1 
ATOM 10547 C C   . LYS D 2 76  ? 20.535  45.182  17.402  1.00 69.19  ? 76  LYS D C   1 
ATOM 10548 O O   . LYS D 2 76  ? 19.459  45.629  17.019  1.00 68.73  ? 76  LYS D O   1 
ATOM 10549 C CB  . LYS D 2 76  ? 22.168  46.719  16.248  1.00 84.86  ? 76  LYS D CB  1 
ATOM 10550 C CG  . LYS D 2 76  ? 23.152  47.880  16.316  1.00 92.00  ? 76  LYS D CG  1 
ATOM 10551 C CD  . LYS D 2 76  ? 23.220  48.646  14.999  1.00 99.90  ? 76  LYS D CD  1 
ATOM 10552 C CE  . LYS D 2 76  ? 24.411  49.534  14.891  1.00 108.63 ? 76  LYS D CE  1 
ATOM 10553 N NZ  . LYS D 2 76  ? 24.566  50.370  16.082  1.00 117.19 ? 76  LYS D NZ  1 
ATOM 10554 N N   . ASN D 2 77  ? 20.726  43.879  17.645  1.00 68.84  ? 77  ASN D N   1 
ATOM 10555 C CA  . ASN D 2 77  ? 19.672  42.896  17.422  1.00 71.98  ? 77  ASN D CA  1 
ATOM 10556 C C   . ASN D 2 77  ? 19.199  42.955  15.972  1.00 67.39  ? 77  ASN D C   1 
ATOM 10557 O O   . ASN D 2 77  ? 18.000  42.873  15.682  1.00 56.53  ? 77  ASN D O   1 
ATOM 10558 C CB  . ASN D 2 77  ? 18.477  43.082  18.349  1.00 73.29  ? 77  ASN D CB  1 
ATOM 10559 C CG  . ASN D 2 77  ? 18.688  42.435  19.691  1.00 78.08  ? 77  ASN D CG  1 
ATOM 10560 O OD1 . ASN D 2 77  ? 17.759  41.809  20.213  1.00 91.24  ? 77  ASN D OD1 1 
ATOM 10561 N ND2 . ASN D 2 77  ? 19.882  42.563  20.257  1.00 82.30  ? 77  ASN D ND2 1 
ATOM 10562 N N   . THR D 2 78  ? 20.172  43.081  15.070  1.00 64.06  ? 78  THR D N   1 
ATOM 10563 C CA  . THR D 2 78  ? 19.876  43.096  13.653  1.00 64.78  ? 78  THR D CA  1 
ATOM 10564 C C   . THR D 2 78  ? 20.696  42.025  12.927  1.00 55.36  ? 78  THR D C   1 
ATOM 10565 O O   . THR D 2 78  ? 21.845  41.730  13.257  1.00 44.52  ? 78  THR D O   1 
ATOM 10566 C CB  . THR D 2 78  ? 20.119  44.490  13.083  1.00 63.71  ? 78  THR D CB  1 
ATOM 10567 O OG1 . THR D 2 78  ? 19.733  44.311  11.723  1.00 63.43  ? 78  THR D OG1 1 
ATOM 10568 C CG2 . THR D 2 78  ? 21.574  44.916  13.160  1.00 64.57  ? 78  THR D CG2 1 
ATOM 10569 N N   . LEU D 2 79  ? 20.055  41.461  11.908  1.00 53.18  ? 79  LEU D N   1 
ATOM 10570 C CA  . LEU D 2 79  ? 20.679  40.533  10.987  1.00 57.67  ? 79  LEU D CA  1 
ATOM 10571 C C   . LEU D 2 79  ? 20.793  41.206  9.624   1.00 58.90  ? 79  LEU D C   1 
ATOM 10572 O O   . LEU D 2 79  ? 19.864  41.896  9.206   1.00 62.92  ? 79  LEU D O   1 
ATOM 10573 C CB  . LEU D 2 79  ? 19.760  39.320  10.931  1.00 58.20  ? 79  LEU D CB  1 
ATOM 10574 C CG  . LEU D 2 79  ? 20.018  38.362  9.775   1.00 59.57  ? 79  LEU D CG  1 
ATOM 10575 C CD1 . LEU D 2 79  ? 21.331  37.619  9.976   1.00 57.98  ? 79  LEU D CD1 1 
ATOM 10576 C CD2 . LEU D 2 79  ? 18.820  37.443  9.667   1.00 62.09  ? 79  LEU D CD2 1 
ATOM 10577 N N   . TYR D 2 80  ? 21.918  41.001  8.934   1.00 53.08  ? 80  TYR D N   1 
ATOM 10578 C CA  . TYR D 2 80  ? 22.117  41.650  7.650   1.00 56.89  ? 80  TYR D CA  1 
ATOM 10579 C C   . TYR D 2 80  ? 22.155  40.609  6.537   1.00 56.50  ? 80  TYR D C   1 
ATOM 10580 O O   . TYR D 2 80  ? 22.230  39.401  6.776   1.00 56.14  ? 80  TYR D O   1 
ATOM 10581 C CB  . TYR D 2 80  ? 23.407  42.472  7.594   1.00 63.56  ? 80  TYR D CB  1 
ATOM 10582 C CG  . TYR D 2 80  ? 23.547  43.571  8.637   1.00 64.88  ? 80  TYR D CG  1 
ATOM 10583 C CD1 . TYR D 2 80  ? 22.604  44.582  8.754   1.00 64.45  ? 80  TYR D CD1 1 
ATOM 10584 C CD2 . TYR D 2 80  ? 24.622  43.576  9.522   1.00 69.17  ? 80  TYR D CD2 1 
ATOM 10585 C CE1 . TYR D 2 80  ? 22.726  45.562  9.728   1.00 70.28  ? 80  TYR D CE1 1 
ATOM 10586 C CE2 . TYR D 2 80  ? 24.759  44.552  10.495  1.00 71.34  ? 80  TYR D CE2 1 
ATOM 10587 C CZ  . TYR D 2 80  ? 23.807  45.550  10.597  1.00 74.16  ? 80  TYR D CZ  1 
ATOM 10588 O OH  . TYR D 2 80  ? 23.969  46.502  11.563  1.00 82.58  ? 80  TYR D OH  1 
ATOM 10589 N N   . LEU D 2 81  ? 22.088  41.130  5.311   1.00 57.15  ? 81  LEU D N   1 
ATOM 10590 C CA  . LEU D 2 81  ? 22.329  40.366  4.099   1.00 59.14  ? 81  LEU D CA  1 
ATOM 10591 C C   . LEU D 2 81  ? 22.835  41.328  3.025   1.00 56.44  ? 81  LEU D C   1 
ATOM 10592 O O   . LEU D 2 81  ? 22.051  42.069  2.428   1.00 49.85  ? 81  LEU D O   1 
ATOM 10593 C CB  . LEU D 2 81  ? 21.061  39.641  3.644   1.00 62.83  ? 81  LEU D CB  1 
ATOM 10594 C CG  . LEU D 2 81  ? 21.163  38.871  2.322   1.00 61.70  ? 81  LEU D CG  1 
ATOM 10595 C CD1 . LEU D 2 81  ? 22.152  37.729  2.458   1.00 61.24  ? 81  LEU D CD1 1 
ATOM 10596 C CD2 . LEU D 2 81  ? 19.813  38.364  1.841   1.00 59.56  ? 81  LEU D CD2 1 
ATOM 10597 N N   . GLN D 2 82  ? 24.154  41.310  2.800   1.00 57.61  ? 82  GLN D N   1 
ATOM 10598 C CA  . GLN D 2 82  ? 24.766  42.094  1.741   1.00 57.91  ? 82  GLN D CA  1 
ATOM 10599 C C   . GLN D 2 82  ? 24.627  41.352  0.412   1.00 56.47  ? 82  GLN D C   1 
ATOM 10600 O O   . GLN D 2 82  ? 25.157  40.259  0.255   1.00 61.85  ? 82  GLN D O   1 
ATOM 10601 C CB  . GLN D 2 82  ? 26.235  42.382  2.042   1.00 56.45  ? 82  GLN D CB  1 
ATOM 10602 C CG  . GLN D 2 82  ? 26.869  43.355  1.052   1.00 57.93  ? 82  GLN D CG  1 
ATOM 10603 C CD  . GLN D 2 82  ? 26.208  44.718  1.040   1.00 59.58  ? 82  GLN D CD  1 
ATOM 10604 O OE1 . GLN D 2 82  ? 25.691  45.161  0.006   1.00 58.10  ? 82  GLN D OE1 1 
ATOM 10605 N NE2 . GLN D 2 82  ? 26.214  45.393  2.188   1.00 59.56  ? 82  GLN D NE2 1 
ATOM 10606 N N   . MET D 2 83  ? 23.914  41.969  -0.533  1.00 59.13  ? 83  MET D N   1 
ATOM 10607 C CA  . MET D 2 83  ? 23.670  41.407  -1.853  1.00 62.52  ? 83  MET D CA  1 
ATOM 10608 C C   . MET D 2 83  ? 24.487  42.166  -2.902  1.00 57.95  ? 83  MET D C   1 
ATOM 10609 O O   . MET D 2 83  ? 24.364  43.377  -3.025  1.00 54.36  ? 83  MET D O   1 
ATOM 10610 C CB  . MET D 2 83  ? 22.181  41.529  -2.191  1.00 61.19  ? 83  MET D CB  1 
ATOM 10611 C CG  . MET D 2 83  ? 21.262  41.123  -1.058  1.00 59.76  ? 83  MET D CG  1 
ATOM 10612 S SD  . MET D 2 83  ? 19.518  41.250  -1.502  1.00 66.86  ? 83  MET D SD  1 
ATOM 10613 C CE  . MET D 2 83  ? 19.248  39.673  -2.331  1.00 61.54  ? 83  MET D CE  1 
ATOM 10614 N N   . ASN D 2 84  ? 25.332  41.460  -3.656  1.00 55.40  ? 84  ASN D N   1 
ATOM 10615 C CA  . ASN D 2 84  ? 26.134  42.111  -4.680  1.00 57.79  ? 84  ASN D CA  1 
ATOM 10616 C C   . ASN D 2 84  ? 25.885  41.467  -6.037  1.00 63.82  ? 84  ASN D C   1 
ATOM 10617 O O   . ASN D 2 84  ? 25.256  40.417  -6.119  1.00 72.86  ? 84  ASN D O   1 
ATOM 10618 C CB  . ASN D 2 84  ? 27.622  42.068  -4.369  1.00 52.24  ? 84  ASN D CB  1 
ATOM 10619 C CG  . ASN D 2 84  ? 27.903  42.684  -3.029  1.00 50.07  ? 84  ASN D CG  1 
ATOM 10620 O OD1 . ASN D 2 84  ? 27.234  43.647  -2.638  1.00 50.65  ? 84  ASN D OD1 1 
ATOM 10621 N ND2 . ASN D 2 84  ? 28.851  42.115  -2.307  1.00 53.75  ? 84  ASN D ND2 1 
ATOM 10622 N N   . SER D 2 85  ? 26.374  42.137  -7.089  1.00 59.34  ? 85  SER D N   1 
ATOM 10623 C CA  . SER D 2 85  ? 26.388  41.598  -8.436  1.00 57.13  ? 85  SER D CA  1 
ATOM 10624 C C   . SER D 2 85  ? 25.018  41.052  -8.823  1.00 55.46  ? 85  SER D C   1 
ATOM 10625 O O   . SER D 2 85  ? 24.960  40.048  -9.525  1.00 58.68  ? 85  SER D O   1 
ATOM 10626 C CB  . SER D 2 85  ? 27.430  40.526  -8.536  1.00 59.83  ? 85  SER D CB  1 
ATOM 10627 O OG  . SER D 2 85  ? 28.610  40.944  -7.868  1.00 63.17  ? 85  SER D OG  1 
ATOM 10628 N N   . LEU D 2 86  ? 23.948  41.731  -8.377  1.00 53.79  ? 86  LEU D N   1 
ATOM 10629 C CA  . LEU D 2 86  ? 22.575  41.240  -8.447  1.00 57.15  ? 86  LEU D CA  1 
ATOM 10630 C C   . LEU D 2 86  ? 22.161  40.888  -9.877  1.00 54.87  ? 86  LEU D C   1 
ATOM 10631 O O   . LEU D 2 86  ? 22.441  41.647  -10.806 1.00 59.72  ? 86  LEU D O   1 
ATOM 10632 C CB  . LEU D 2 86  ? 21.639  42.311  -7.887  1.00 62.61  ? 86  LEU D CB  1 
ATOM 10633 C CG  . LEU D 2 86  ? 21.603  42.470  -6.364  1.00 65.65  ? 86  LEU D CG  1 
ATOM 10634 C CD1 . LEU D 2 86  ? 21.209  43.898  -6.041  1.00 67.55  ? 86  LEU D CD1 1 
ATOM 10635 C CD2 . LEU D 2 86  ? 20.634  41.498  -5.708  1.00 61.21  ? 86  LEU D CD2 1 
ATOM 10636 N N   . LYS D 2 87  ? 21.436  39.765  -10.014 1.00 49.88  ? 87  LYS D N   1 
ATOM 10637 C CA  . LYS D 2 87  ? 20.924  39.266  -11.284 1.00 55.81  ? 87  LYS D CA  1 
ATOM 10638 C C   . LYS D 2 87  ? 19.403  39.399  -11.315 1.00 57.90  ? 87  LYS D C   1 
ATOM 10639 O O   . LYS D 2 87  ? 18.757  39.416  -10.275 1.00 61.13  ? 87  LYS D O   1 
ATOM 10640 C CB  . LYS D 2 87  ? 21.270  37.782  -11.460 1.00 61.75  ? 87  LYS D CB  1 
ATOM 10641 C CG  . LYS D 2 87  ? 22.746  37.484  -11.328 1.00 70.26  ? 87  LYS D CG  1 
ATOM 10642 C CD  . LYS D 2 87  ? 23.157  36.018  -11.380 1.00 77.05  ? 87  LYS D CD  1 
ATOM 10643 C CE  . LYS D 2 87  ? 24.614  35.875  -11.015 1.00 90.28  ? 87  LYS D CE  1 
ATOM 10644 N NZ  . LYS D 2 87  ? 25.509  36.882  -11.607 1.00 97.60  ? 87  LYS D NZ  1 
ATOM 10645 N N   . PRO D 2 88  ? 18.752  39.517  -12.491 1.00 65.97  ? 88  PRO D N   1 
ATOM 10646 C CA  . PRO D 2 88  ? 17.289  39.462  -12.534 1.00 66.59  ? 88  PRO D CA  1 
ATOM 10647 C C   . PRO D 2 88  ? 16.751  38.221  -11.822 1.00 67.04  ? 88  PRO D C   1 
ATOM 10648 O O   . PRO D 2 88  ? 15.729  38.303  -11.144 1.00 65.42  ? 88  PRO D O   1 
ATOM 10649 C CB  . PRO D 2 88  ? 16.963  39.508  -14.036 1.00 64.29  ? 88  PRO D CB  1 
ATOM 10650 C CG  . PRO D 2 88  ? 18.146  40.258  -14.627 1.00 69.73  ? 88  PRO D CG  1 
ATOM 10651 C CD  . PRO D 2 88  ? 19.356  39.799  -13.804 1.00 69.77  ? 88  PRO D CD  1 
ATOM 10652 N N   . GLU D 2 89  ? 17.472  37.094  -11.950 1.00 73.88  ? 89  GLU D N   1 
ATOM 10653 C CA  . GLU D 2 89  ? 17.139  35.835  -11.284 1.00 72.45  ? 89  GLU D CA  1 
ATOM 10654 C C   . GLU D 2 89  ? 16.682  36.101  -9.846  1.00 61.54  ? 89  GLU D C   1 
ATOM 10655 O O   . GLU D 2 89  ? 15.580  35.719  -9.467  1.00 58.40  ? 89  GLU D O   1 
ATOM 10656 C CB  . GLU D 2 89  ? 18.300  34.829  -11.205 1.00 79.12  ? 89  GLU D CB  1 
ATOM 10657 C CG  . GLU D 2 89  ? 19.254  34.786  -12.401 1.00 84.47  ? 89  GLU D CG  1 
ATOM 10658 C CD  . GLU D 2 89  ? 18.623  34.628  -13.770 1.00 93.42  ? 89  GLU D CD  1 
ATOM 10659 O OE1 . GLU D 2 89  ? 17.681  33.819  -13.925 1.00 99.22  ? 89  GLU D OE1 1 
ATOM 10660 O OE2 . GLU D 2 89  ? 19.101  35.329  -14.688 1.00 101.92 ? 89  GLU D OE2 1 
ATOM 10661 N N   . ASP D 2 90  ? 17.523  36.828  -9.093  1.00 56.09  ? 90  ASP D N   1 
ATOM 10662 C CA  . ASP D 2 90  ? 17.430  37.005  -7.650  1.00 51.12  ? 90  ASP D CA  1 
ATOM 10663 C C   . ASP D 2 90  ? 16.160  37.734  -7.229  1.00 47.49  ? 90  ASP D C   1 
ATOM 10664 O O   . ASP D 2 90  ? 15.913  37.886  -6.040  1.00 46.32  ? 90  ASP D O   1 
ATOM 10665 C CB  . ASP D 2 90  ? 18.623  37.788  -7.113  1.00 50.89  ? 90  ASP D CB  1 
ATOM 10666 C CG  . ASP D 2 90  ? 19.986  37.134  -7.319  1.00 49.96  ? 90  ASP D CG  1 
ATOM 10667 O OD1 . ASP D 2 90  ? 20.042  35.889  -7.399  1.00 47.65  ? 90  ASP D OD1 1 
ATOM 10668 O OD2 . ASP D 2 90  ? 20.986  37.869  -7.385  1.00 46.61  ? 90  ASP D OD2 1 
ATOM 10669 N N   . THR D 2 91  ? 15.372  38.199  -8.197  1.00 51.98  ? 91  THR D N   1 
ATOM 10670 C CA  . THR D 2 91  ? 14.146  38.920  -7.896  1.00 56.59  ? 91  THR D CA  1 
ATOM 10671 C C   . THR D 2 91  ? 13.260  38.048  -7.016  1.00 55.35  ? 91  THR D C   1 
ATOM 10672 O O   . THR D 2 91  ? 12.830  36.990  -7.459  1.00 65.17  ? 91  THR D O   1 
ATOM 10673 C CB  . THR D 2 91  ? 13.434  39.303  -9.193  1.00 55.16  ? 91  THR D CB  1 
ATOM 10674 O OG1 . THR D 2 91  ? 14.179  40.408  -9.693  1.00 58.03  ? 91  THR D OG1 1 
ATOM 10675 C CG2 . THR D 2 91  ? 11.994  39.722  -8.966  1.00 57.20  ? 91  THR D CG2 1 
ATOM 10676 N N   . ALA D 2 92  ? 12.977  38.510  -5.791  1.00 52.13  ? 92  ALA D N   1 
ATOM 10677 C CA  . ALA D 2 92  ? 12.170  37.735  -4.866  1.00 56.79  ? 92  ALA D CA  1 
ATOM 10678 C C   . ALA D 2 92  ? 11.640  38.568  -3.698  1.00 63.63  ? 92  ALA D C   1 
ATOM 10679 O O   . ALA D 2 92  ? 12.051  39.706  -3.444  1.00 53.22  ? 92  ALA D O   1 
ATOM 10680 C CB  . ALA D 2 92  ? 12.985  36.569  -4.354  1.00 57.63  ? 92  ALA D CB  1 
ATOM 10681 N N   . ARG D 2 93  ? 10.683  37.957  -2.992  1.00 72.78  ? 93  ARG D N   1 
ATOM 10682 C CA  . ARG D 2 93  ? 10.360  38.343  -1.634  1.00 73.61  ? 93  ARG D CA  1 
ATOM 10683 C C   . ARG D 2 93  ? 11.354  37.647  -0.707  1.00 66.23  ? 93  ARG D C   1 
ATOM 10684 O O   . ARG D 2 93  ? 11.438  36.419  -0.701  1.00 58.11  ? 93  ARG D O   1 
ATOM 10685 C CB  . ARG D 2 93  ? 8.908   37.961  -1.330  1.00 77.23  ? 93  ARG D CB  1 
ATOM 10686 C CG  . ARG D 2 93  ? 8.452   38.427  0.043   1.00 83.19  ? 93  ARG D CG  1 
ATOM 10687 C CD  . ARG D 2 93  ? 6.935   38.445  0.144   1.00 88.84  ? 93  ARG D CD  1 
ATOM 10688 N NE  . ARG D 2 93  ? 6.349   39.519  -0.669  1.00 91.45  ? 93  ARG D NE  1 
ATOM 10689 C CZ  . ARG D 2 93  ? 6.405   40.826  -0.403  1.00 87.00  ? 93  ARG D CZ  1 
ATOM 10690 N NH1 . ARG D 2 93  ? 6.872   41.257  0.762   1.00 75.42  ? 93  ARG D NH1 1 
ATOM 10691 N NH2 . ARG D 2 93  ? 5.961   41.694  -1.306  1.00 88.88  ? 93  ARG D NH2 1 
ATOM 10692 N N   . TYR D 2 94  ? 12.130  38.454  0.028   1.00 64.20  ? 94  TYR D N   1 
ATOM 10693 C CA  . TYR D 2 94  ? 13.112  37.959  0.981   1.00 64.29  ? 94  TYR D CA  1 
ATOM 10694 C C   . TYR D 2 94  ? 12.519  38.030  2.385   1.00 65.85  ? 94  TYR D C   1 
ATOM 10695 O O   . TYR D 2 94  ? 11.788  38.958  2.718   1.00 70.72  ? 94  TYR D O   1 
ATOM 10696 C CB  . TYR D 2 94  ? 14.440  38.719  0.880   1.00 61.70  ? 94  TYR D CB  1 
ATOM 10697 C CG  . TYR D 2 94  ? 15.206  38.382  -0.391  1.00 59.88  ? 94  TYR D CG  1 
ATOM 10698 C CD1 . TYR D 2 94  ? 14.824  38.910  -1.619  1.00 61.74  ? 94  TYR D CD1 1 
ATOM 10699 C CD2 . TYR D 2 94  ? 16.295  37.526  -0.368  1.00 59.72  ? 94  TYR D CD2 1 
ATOM 10700 C CE1 . TYR D 2 94  ? 15.497  38.598  -2.788  1.00 60.92  ? 94  TYR D CE1 1 
ATOM 10701 C CE2 . TYR D 2 94  ? 16.982  37.211  -1.532  1.00 66.28  ? 94  TYR D CE2 1 
ATOM 10702 C CZ  . TYR D 2 94  ? 16.575  37.738  -2.748  1.00 60.77  ? 94  TYR D CZ  1 
ATOM 10703 O OH  . TYR D 2 94  ? 17.228  37.451  -3.910  1.00 55.01  ? 94  TYR D OH  1 
ATOM 10704 N N   . TYR D 2 95  ? 12.877  37.034  3.201   1.00 66.57  ? 95  TYR D N   1 
ATOM 10705 C CA  . TYR D 2 95  ? 12.247  36.770  4.481   1.00 59.58  ? 95  TYR D CA  1 
ATOM 10706 C C   . TYR D 2 95  ? 13.304  36.424  5.530   1.00 64.58  ? 95  TYR D C   1 
ATOM 10707 O O   . TYR D 2 95  ? 14.341  35.825  5.228   1.00 54.44  ? 95  TYR D O   1 
ATOM 10708 C CB  . TYR D 2 95  ? 11.309  35.573  4.362   1.00 53.35  ? 95  TYR D CB  1 
ATOM 10709 C CG  . TYR D 2 95  ? 9.943   35.790  3.730   1.00 52.02  ? 95  TYR D CG  1 
ATOM 10710 C CD1 . TYR D 2 95  ? 8.897   36.352  4.453   1.00 51.99  ? 95  TYR D CD1 1 
ATOM 10711 C CD2 . TYR D 2 95  ? 9.660   35.306  2.462   1.00 52.53  ? 95  TYR D CD2 1 
ATOM 10712 C CE1 . TYR D 2 95  ? 7.628   36.477  3.912   1.00 51.47  ? 95  TYR D CE1 1 
ATOM 10713 C CE2 . TYR D 2 95  ? 8.395   35.426  1.909   1.00 53.51  ? 95  TYR D CE2 1 
ATOM 10714 C CZ  . TYR D 2 95  ? 7.378   36.014  2.631   1.00 52.58  ? 95  TYR D CZ  1 
ATOM 10715 O OH  . TYR D 2 95  ? 6.156   36.113  2.025   1.00 60.27  ? 95  TYR D OH  1 
ATOM 10716 N N   . CYS D 2 96  ? 13.000  36.791  6.779   1.00 73.65  ? 96  CYS D N   1 
ATOM 10717 C CA  . CYS D 2 96  ? 13.883  36.551  7.908   1.00 74.45  ? 96  CYS D CA  1 
ATOM 10718 C C   . CYS D 2 96  ? 13.262  35.451  8.765   1.00 69.90  ? 96  CYS D C   1 
ATOM 10719 O O   . CYS D 2 96  ? 12.061  35.489  9.026   1.00 74.46  ? 96  CYS D O   1 
ATOM 10720 C CB  . CYS D 2 96  ? 14.100  37.841  8.693   1.00 77.75  ? 96  CYS D CB  1 
ATOM 10721 S SG  . CYS D 2 96  ? 15.558  37.802  9.770   1.00 93.86  ? 96  CYS D SG  1 
ATOM 10722 N N   . ALA D 2 97  ? 14.073  34.462  9.169   1.00 62.31  ? 97  ALA D N   1 
ATOM 10723 C CA  . ALA D 2 97  ? 13.586  33.346  9.969   1.00 59.27  ? 97  ALA D CA  1 
ATOM 10724 C C   . ALA D 2 97  ? 14.488  33.135  11.173  1.00 52.40  ? 97  ALA D C   1 
ATOM 10725 O O   . ALA D 2 97  ? 15.699  33.348  11.097  1.00 51.68  ? 97  ALA D O   1 
ATOM 10726 C CB  . ALA D 2 97  ? 13.506  32.067  9.161   1.00 58.08  ? 97  ALA D CB  1 
ATOM 10727 N N   . ALA D 2 98  ? 13.876  32.624  12.242  1.00 46.62  ? 98  ALA D N   1 
ATOM 10728 C CA  . ALA D 2 98  ? 14.576  32.388  13.490  1.00 49.01  ? 98  ALA D CA  1 
ATOM 10729 C C   . ALA D 2 98  ? 14.309  30.973  14.005  1.00 47.15  ? 98  ALA D C   1 
ATOM 10730 O O   . ALA D 2 98  ? 13.163  30.535  14.093  1.00 44.89  ? 98  ALA D O   1 
ATOM 10731 C CB  . ALA D 2 98  ? 14.150  33.442  14.477  1.00 52.56  ? 98  ALA D CB  1 
ATOM 10732 N N   . GLY D 2 99  ? 15.389  30.261  14.351  1.00 47.16  ? 99  GLY D N   1 
ATOM 10733 C CA  . GLY D 2 99  ? 15.297  28.842  14.648  1.00 52.56  ? 99  GLY D CA  1 
ATOM 10734 C C   . GLY D 2 99  ? 16.456  28.358  15.516  1.00 53.28  ? 99  GLY D C   1 
ATOM 10735 O O   . GLY D 2 99  ? 17.280  29.163  15.956  1.00 51.90  ? 99  GLY D O   1 
ATOM 10736 N N   . SER D 2 100 ? 16.492  27.035  15.741  1.00 52.38  ? 100 SER D N   1 
ATOM 10737 C CA  . SER D 2 100 ? 17.359  26.429  16.737  1.00 54.61  ? 100 SER D CA  1 
ATOM 10738 C C   . SER D 2 100 ? 18.537  25.741  16.069  1.00 59.99  ? 100 SER D C   1 
ATOM 10739 O O   . SER D 2 100 ? 19.422  25.250  16.769  1.00 54.59  ? 100 SER D O   1 
ATOM 10740 C CB  . SER D 2 100 ? 16.606  25.426  17.530  1.00 56.29  ? 100 SER D CB  1 
ATOM 10741 O OG  . SER D 2 100 ? 16.244  24.355  16.670  1.00 58.83  ? 100 SER D OG  1 
ATOM 10742 N N   . THR D 2 101 ? 18.501  25.705  14.727  1.00 70.20  ? 101 THR D N   1 
ATOM 10743 C CA  . THR D 2 101 ? 19.410  24.914  13.912  1.00 73.50  ? 101 THR D CA  1 
ATOM 10744 C C   . THR D 2 101 ? 19.949  25.775  12.770  1.00 79.22  ? 101 THR D C   1 
ATOM 10745 O O   . THR D 2 101 ? 19.290  26.722  12.325  1.00 82.87  ? 101 THR D O   1 
ATOM 10746 C CB  . THR D 2 101 ? 18.647  23.712  13.359  1.00 72.54  ? 101 THR D CB  1 
ATOM 10747 O OG1 . THR D 2 101 ? 17.481  24.299  12.784  1.00 80.43  ? 101 THR D OG1 1 
ATOM 10748 C CG2 . THR D 2 101 ? 18.257  22.715  14.432  1.00 73.22  ? 101 THR D CG2 1 
ATOM 10749 N N   . LEU D 2 102 ? 21.126  25.380  12.268  1.00 71.12  ? 102 LEU D N   1 
ATOM 10750 C CA  . LEU D 2 102 ? 21.712  25.953  11.066  1.00 61.19  ? 102 LEU D CA  1 
ATOM 10751 C C   . LEU D 2 102 ? 21.225  25.186  9.839   1.00 55.98  ? 102 LEU D C   1 
ATOM 10752 O O   . LEU D 2 102 ? 22.037  24.818  9.001   1.00 56.08  ? 102 LEU D O   1 
ATOM 10753 C CB  . LEU D 2 102 ? 23.226  25.825  11.246  1.00 60.77  ? 102 LEU D CB  1 
ATOM 10754 C CG  . LEU D 2 102 ? 24.129  26.329  10.115  1.00 57.27  ? 102 LEU D CG  1 
ATOM 10755 C CD1 . LEU D 2 102 ? 24.644  27.725  10.385  1.00 53.50  ? 102 LEU D CD1 1 
ATOM 10756 C CD2 . LEU D 2 102 ? 25.271  25.338  9.879   1.00 60.03  ? 102 LEU D CD2 1 
ATOM 10757 N N   . THR D 2 103 ? 19.915  24.912  9.736   1.00 60.04  ? 103 THR D N   1 
ATOM 10758 C CA  . THR D 2 103 ? 19.414  24.018  8.696   1.00 66.83  ? 103 THR D CA  1 
ATOM 10759 C C   . THR D 2 103 ? 18.627  24.857  7.688   1.00 62.82  ? 103 THR D C   1 
ATOM 10760 O O   . THR D 2 103 ? 18.307  26.015  7.965   1.00 54.66  ? 103 THR D O   1 
ATOM 10761 C CB  . THR D 2 103 ? 18.610  22.865  9.318   1.00 71.94  ? 103 THR D CB  1 
ATOM 10762 O OG1 . THR D 2 103 ? 19.003  21.605  8.766   1.00 68.75  ? 103 THR D OG1 1 
ATOM 10763 C CG2 . THR D 2 103 ? 17.106  23.036  9.190   1.00 71.36  ? 103 THR D CG2 1 
ATOM 10764 N N   . MET D 2 104 ? 18.354  24.277  6.508   1.00 60.63  ? 104 MET D N   1 
ATOM 10765 C CA  . MET D 2 104 ? 17.739  25.031  5.424   1.00 62.97  ? 104 MET D CA  1 
ATOM 10766 C C   . MET D 2 104 ? 16.308  24.576  5.179   1.00 53.22  ? 104 MET D C   1 
ATOM 10767 O O   . MET D 2 104 ? 15.802  24.737  4.082   1.00 51.66  ? 104 MET D O   1 
ATOM 10768 C CB  . MET D 2 104 ? 18.555  24.948  4.131   1.00 64.10  ? 104 MET D CB  1 
ATOM 10769 C CG  . MET D 2 104 ? 19.875  25.641  4.283   1.00 72.61  ? 104 MET D CG  1 
ATOM 10770 S SD  . MET D 2 104 ? 20.745  25.999  2.751   1.00 95.32  ? 104 MET D SD  1 
ATOM 10771 C CE  . MET D 2 104 ? 19.830  27.444  2.208   1.00 88.04  ? 104 MET D CE  1 
ATOM 10772 N N   . VAL D 2 105 ? 15.625  24.167  6.245   1.00 53.99  ? 105 VAL D N   1 
ATOM 10773 C CA  . VAL D 2 105 ? 14.292  23.607  6.146   1.00 60.50  ? 105 VAL D CA  1 
ATOM 10774 C C   . VAL D 2 105 ? 13.286  24.606  6.712   1.00 61.53  ? 105 VAL D C   1 
ATOM 10775 O O   . VAL D 2 105 ? 13.360  24.959  7.889   1.00 61.53  ? 105 VAL D O   1 
ATOM 10776 C CB  . VAL D 2 105 ? 14.181  22.266  6.900   1.00 65.43  ? 105 VAL D CB  1 
ATOM 10777 C CG1 . VAL D 2 105 ? 12.851  21.584  6.596   1.00 69.76  ? 105 VAL D CG1 1 
ATOM 10778 C CG2 . VAL D 2 105 ? 15.345  21.328  6.602   1.00 60.26  ? 105 VAL D CG2 1 
ATOM 10779 N N   . VAL D 2 106 ? 12.329  25.006  5.864   1.00 62.19  ? 106 VAL D N   1 
ATOM 10780 C CA  . VAL D 2 106 ? 11.270  25.942  6.215   1.00 61.76  ? 106 VAL D CA  1 
ATOM 10781 C C   . VAL D 2 106 ? 10.582  25.517  7.509   1.00 60.86  ? 106 VAL D C   1 
ATOM 10782 O O   . VAL D 2 106 ? 10.369  26.342  8.399   1.00 67.08  ? 106 VAL D O   1 
ATOM 10783 C CB  . VAL D 2 106 ? 10.254  26.039  5.059   1.00 62.83  ? 106 VAL D CB  1 
ATOM 10784 C CG1 . VAL D 2 106 ? 8.881   26.518  5.525   1.00 63.46  ? 106 VAL D CG1 1 
ATOM 10785 C CG2 . VAL D 2 106 ? 10.788  26.902  3.919   1.00 61.45  ? 106 VAL D CG2 1 
ATOM 10786 N N   . ALA D 2 107 ? 10.208  24.238  7.587   1.00 55.88  ? 107 ALA D N   1 
ATOM 10787 C CA  . ALA D 2 107 ? 9.404   23.754  8.694   1.00 57.46  ? 107 ALA D CA  1 
ATOM 10788 C C   . ALA D 2 107 ? 10.131  23.963  10.024  1.00 58.91  ? 107 ALA D C   1 
ATOM 10789 O O   . ALA D 2 107 ? 9.481   24.275  11.021  1.00 62.43  ? 107 ALA D O   1 
ATOM 10790 C CB  . ALA D 2 107 ? 9.047   22.302  8.458   1.00 60.87  ? 107 ALA D CB  1 
ATOM 10791 N N   . ASN D 2 108 ? 11.473  23.827  10.012  1.00 59.43  ? 108 ASN D N   1 
ATOM 10792 C CA  . ASN D 2 108 ? 12.301  23.829  11.215  1.00 55.06  ? 108 ASN D CA  1 
ATOM 10793 C C   . ASN D 2 108 ? 12.476  25.223  11.826  1.00 58.12  ? 108 ASN D C   1 
ATOM 10794 O O   . ASN D 2 108 ? 13.039  25.329  12.902  1.00 69.33  ? 108 ASN D O   1 
ATOM 10795 C CB  . ASN D 2 108 ? 13.683  23.234  10.949  1.00 54.51  ? 108 ASN D CB  1 
ATOM 10796 C CG  . ASN D 2 108 ? 13.694  21.721  10.961  1.00 58.36  ? 108 ASN D CG  1 
ATOM 10797 O OD1 . ASN D 2 108 ? 12.647  21.079  10.828  1.00 63.84  ? 108 ASN D OD1 1 
ATOM 10798 N ND2 . ASN D 2 108 ? 14.866  21.122  11.119  1.00 57.12  ? 108 ASN D ND2 1 
ATOM 10799 N N   . TYR D 2 109 ? 12.030  26.303  11.175  1.00 62.99  ? 109 TYR D N   1 
ATOM 10800 C CA  . TYR D 2 109 ? 12.207  27.642  11.723  1.00 61.44  ? 109 TYR D CA  1 
ATOM 10801 C C   . TYR D 2 109 ? 10.900  28.134  12.348  1.00 61.06  ? 109 TYR D C   1 
ATOM 10802 O O   . TYR D 2 109 ? 9.861   28.191  11.677  1.00 54.78  ? 109 TYR D O   1 
ATOM 10803 C CB  . TYR D 2 109 ? 12.708  28.586  10.626  1.00 62.10  ? 109 TYR D CB  1 
ATOM 10804 C CG  . TYR D 2 109 ? 14.189  28.431  10.326  1.00 58.21  ? 109 TYR D CG  1 
ATOM 10805 C CD1 . TYR D 2 109 ? 15.133  29.055  11.123  1.00 57.39  ? 109 TYR D CD1 1 
ATOM 10806 C CD2 . TYR D 2 109 ? 14.646  27.664  9.259   1.00 56.77  ? 109 TYR D CD2 1 
ATOM 10807 C CE1 . TYR D 2 109 ? 16.489  28.938  10.866  1.00 58.35  ? 109 TYR D CE1 1 
ATOM 10808 C CE2 . TYR D 2 109 ? 16.002  27.540  8.986   1.00 56.03  ? 109 TYR D CE2 1 
ATOM 10809 C CZ  . TYR D 2 109 ? 16.926  28.183  9.796   1.00 57.86  ? 109 TYR D CZ  1 
ATOM 10810 O OH  . TYR D 2 109 ? 18.279  28.113  9.636   1.00 61.10  ? 109 TYR D OH  1 
ATOM 10811 N N   . ARG D 2 110 ? 10.994  28.540  13.623  1.00 57.60  ? 110 ARG D N   1 
ATOM 10812 C CA  . ARG D 2 110 ? 9.820   28.834  14.428  1.00 60.13  ? 110 ARG D CA  1 
ATOM 10813 C C   . ARG D 2 110 ? 9.213   30.184  14.035  1.00 58.95  ? 110 ARG D C   1 
ATOM 10814 O O   . ARG D 2 110 ? 7.999   30.256  13.866  1.00 57.08  ? 110 ARG D O   1 
ATOM 10815 C CB  . ARG D 2 110 ? 10.140  28.751  15.928  1.00 62.09  ? 110 ARG D CB  1 
ATOM 10816 C CG  . ARG D 2 110 ? 8.882   28.632  16.779  1.00 64.03  ? 110 ARG D CG  1 
ATOM 10817 C CD  . ARG D 2 110 ? 9.140   28.743  18.260  1.00 67.06  ? 110 ARG D CD  1 
ATOM 10818 N NE  . ARG D 2 110 ? 7.913   28.489  19.021  1.00 76.04  ? 110 ARG D NE  1 
ATOM 10819 C CZ  . ARG D 2 110 ? 7.878   28.267  20.331  1.00 89.80  ? 110 ARG D CZ  1 
ATOM 10820 N NH1 . ARG D 2 110 ? 8.966   28.452  21.055  1.00 87.18  ? 110 ARG D NH1 1 
ATOM 10821 N NH2 . ARG D 2 110 ? 6.762   27.859  20.919  1.00 105.33 ? 110 ARG D NH2 1 
ATOM 10822 N N   . TYR D 2 111 ? 10.044  31.234  13.886  1.00 62.10  ? 111 TYR D N   1 
ATOM 10823 C CA  . TYR D 2 111 ? 9.565   32.604  13.722  1.00 63.12  ? 111 TYR D CA  1 
ATOM 10824 C C   . TYR D 2 111 ? 9.992   33.228  12.391  1.00 64.29  ? 111 TYR D C   1 
ATOM 10825 O O   . TYR D 2 111 ? 11.151  33.142  11.990  1.00 63.64  ? 111 TYR D O   1 
ATOM 10826 C CB  . TYR D 2 111 ? 10.103  33.488  14.843  1.00 63.74  ? 111 TYR D CB  1 
ATOM 10827 C CG  . TYR D 2 111 ? 9.703   33.025  16.235  1.00 66.61  ? 111 TYR D CG  1 
ATOM 10828 C CD1 . TYR D 2 111 ? 8.386   33.135  16.678  1.00 60.83  ? 111 TYR D CD1 1 
ATOM 10829 C CD2 . TYR D 2 111 ? 10.654  32.513  17.113  1.00 63.93  ? 111 TYR D CD2 1 
ATOM 10830 C CE1 . TYR D 2 111 ? 8.027   32.733  17.954  1.00 59.58  ? 111 TYR D CE1 1 
ATOM 10831 C CE2 . TYR D 2 111 ? 10.307  32.112  18.393  1.00 62.91  ? 111 TYR D CE2 1 
ATOM 10832 C CZ  . TYR D 2 111 ? 8.990   32.220  18.810  1.00 63.14  ? 111 TYR D CZ  1 
ATOM 10833 O OH  . TYR D 2 111 ? 8.664   31.818  20.072  1.00 59.21  ? 111 TYR D OH  1 
ATOM 10834 N N   . TRP D 2 112 ? 9.043   33.929  11.760  1.00 63.62  ? 112 TRP D N   1 
ATOM 10835 C CA  . TRP D 2 112 ? 9.200   34.445  10.415  1.00 64.46  ? 112 TRP D CA  1 
ATOM 10836 C C   . TRP D 2 112 ? 8.852   35.925  10.381  1.00 65.84  ? 112 TRP D C   1 
ATOM 10837 O O   . TRP D 2 112 ? 8.043   36.384  11.176  1.00 74.83  ? 112 TRP D O   1 
ATOM 10838 C CB  . TRP D 2 112 ? 8.293   33.657  9.467   1.00 68.36  ? 112 TRP D CB  1 
ATOM 10839 C CG  . TRP D 2 112 ? 8.788   32.258  9.230   1.00 77.09  ? 112 TRP D CG  1 
ATOM 10840 C CD1 . TRP D 2 112 ? 8.472   31.128  9.927   1.00 83.63  ? 112 TRP D CD1 1 
ATOM 10841 C CD2 . TRP D 2 112 ? 9.722   31.851  8.208   1.00 79.31  ? 112 TRP D CD2 1 
ATOM 10842 N NE1 . TRP D 2 112 ? 9.136   30.047  9.409   1.00 87.91  ? 112 TRP D NE1 1 
ATOM 10843 C CE2 . TRP D 2 112 ? 9.909   30.458  8.354   1.00 82.41  ? 112 TRP D CE2 1 
ATOM 10844 C CE3 . TRP D 2 112 ? 10.408  32.527  7.191   1.00 73.17  ? 112 TRP D CE3 1 
ATOM 10845 C CZ2 . TRP D 2 112 ? 10.756  29.734  7.517   1.00 77.82  ? 112 TRP D CZ2 1 
ATOM 10846 C CZ3 . TRP D 2 112 ? 11.244  31.810  6.363   1.00 72.04  ? 112 TRP D CZ3 1 
ATOM 10847 C CH2 . TRP D 2 112 ? 11.418  30.434  6.531   1.00 77.39  ? 112 TRP D CH2 1 
ATOM 10848 N N   . GLY D 2 113 ? 9.452   36.648  9.431   1.00 70.02  ? 113 GLY D N   1 
ATOM 10849 C CA  . GLY D 2 113 ? 9.109   38.036  9.162   1.00 69.92  ? 113 GLY D CA  1 
ATOM 10850 C C   . GLY D 2 113 ? 8.011   38.162  8.105   1.00 68.64  ? 113 GLY D C   1 
ATOM 10851 O O   . GLY D 2 113 ? 7.482   37.157  7.614   1.00 66.48  ? 113 GLY D O   1 
ATOM 10852 N N   . GLN D 2 114 ? 7.668   39.412  7.776   1.00 60.76  ? 114 GLN D N   1 
ATOM 10853 C CA  . GLN D 2 114 ? 6.574   39.680  6.862   1.00 69.21  ? 114 GLN D CA  1 
ATOM 10854 C C   . GLN D 2 114 ? 7.084   39.711  5.424   1.00 74.37  ? 114 GLN D C   1 
ATOM 10855 O O   . GLN D 2 114 ? 6.322   39.446  4.493   1.00 76.45  ? 114 GLN D O   1 
ATOM 10856 C CB  . GLN D 2 114 ? 5.862   40.974  7.255   1.00 84.77  ? 114 GLN D CB  1 
ATOM 10857 C CG  . GLN D 2 114 ? 4.968   40.837  8.485   1.00 97.90  ? 114 GLN D CG  1 
ATOM 10858 C CD  . GLN D 2 114 ? 4.051   39.630  8.431   1.00 101.07 ? 114 GLN D CD  1 
ATOM 10859 O OE1 . GLN D 2 114 ? 3.328   39.413  7.451   1.00 106.41 ? 114 GLN D OE1 1 
ATOM 10860 N NE2 . GLN D 2 114 ? 4.082   38.818  9.478   1.00 99.61  ? 114 GLN D NE2 1 
ATOM 10861 N N   . GLY D 2 115 ? 8.360   40.087  5.261   1.00 76.06  ? 115 GLY D N   1 
ATOM 10862 C CA  . GLY D 2 115 ? 9.067   39.966  3.996   1.00 69.16  ? 115 GLY D CA  1 
ATOM 10863 C C   . GLY D 2 115 ? 9.138   41.297  3.252   1.00 68.25  ? 115 GLY D C   1 
ATOM 10864 O O   . GLY D 2 115 ? 8.118   41.954  3.065   1.00 66.52  ? 115 GLY D O   1 
ATOM 10865 N N   . THR D 2 116 ? 10.352  41.663  2.815   1.00 68.48  ? 116 THR D N   1 
ATOM 10866 C CA  . THR D 2 116 ? 10.576  42.819  1.960   1.00 66.11  ? 116 THR D CA  1 
ATOM 10867 C C   . THR D 2 116 ? 10.938  42.363  0.546   1.00 65.47  ? 116 THR D C   1 
ATOM 10868 O O   . THR D 2 116 ? 11.672  41.395  0.369   1.00 66.46  ? 116 THR D O   1 
ATOM 10869 C CB  . THR D 2 116 ? 11.681  43.684  2.559   1.00 68.82  ? 116 THR D CB  1 
ATOM 10870 O OG1 . THR D 2 116 ? 11.445  44.914  1.881   1.00 71.01  ? 116 THR D OG1 1 
ATOM 10871 C CG2 . THR D 2 116 ? 13.076  43.113  2.347   1.00 68.21  ? 116 THR D CG2 1 
ATOM 10872 N N   . LEU D 2 117 ? 10.463  43.115  -0.456  1.00 68.52  ? 117 LEU D N   1 
ATOM 10873 C CA  . LEU D 2 117 ? 10.491  42.693  -1.851  1.00 65.32  ? 117 LEU D CA  1 
ATOM 10874 C C   . LEU D 2 117 ? 11.721  43.261  -2.545  1.00 63.41  ? 117 LEU D C   1 
ATOM 10875 O O   . LEU D 2 117 ? 11.907  44.475  -2.549  1.00 73.30  ? 117 LEU D O   1 
ATOM 10876 C CB  . LEU D 2 117 ? 9.223   43.183  -2.555  1.00 64.48  ? 117 LEU D CB  1 
ATOM 10877 C CG  . LEU D 2 117 ? 9.106   42.849  -4.046  1.00 60.95  ? 117 LEU D CG  1 
ATOM 10878 C CD1 . LEU D 2 117 ? 8.810   41.382  -4.242  1.00 60.85  ? 117 LEU D CD1 1 
ATOM 10879 C CD2 . LEU D 2 117 ? 8.041   43.688  -4.708  1.00 62.58  ? 117 LEU D CD2 1 
ATOM 10880 N N   . VAL D 2 118 ? 12.503  42.384  -3.189  1.00 61.83  ? 118 VAL D N   1 
ATOM 10881 C CA  . VAL D 2 118 ? 13.641  42.802  -3.997  1.00 61.34  ? 118 VAL D CA  1 
ATOM 10882 C C   . VAL D 2 118 ? 13.322  42.538  -5.466  1.00 58.03  ? 118 VAL D C   1 
ATOM 10883 O O   . VAL D 2 118 ? 13.077  41.393  -5.831  1.00 50.28  ? 118 VAL D O   1 
ATOM 10884 C CB  . VAL D 2 118 ? 14.954  42.085  -3.624  1.00 65.52  ? 118 VAL D CB  1 
ATOM 10885 C CG1 . VAL D 2 118 ? 16.077  42.445  -4.589  1.00 65.52  ? 118 VAL D CG1 1 
ATOM 10886 C CG2 . VAL D 2 118 ? 15.386  42.351  -2.186  1.00 67.28  ? 118 VAL D CG2 1 
ATOM 10887 N N   . THR D 2 119 ? 13.353  43.598  -6.290  1.00 60.06  ? 119 THR D N   1 
ATOM 10888 C CA  . THR D 2 119 ? 13.216  43.473  -7.733  1.00 55.21  ? 119 THR D CA  1 
ATOM 10889 C C   . THR D 2 119 ? 14.543  43.874  -8.360  1.00 59.85  ? 119 THR D C   1 
ATOM 10890 O O   . THR D 2 119 ? 15.162  44.836  -7.916  1.00 61.86  ? 119 THR D O   1 
ATOM 10891 C CB  . THR D 2 119 ? 12.084  44.343  -8.278  1.00 51.85  ? 119 THR D CB  1 
ATOM 10892 O OG1 . THR D 2 119 ? 10.885  44.079  -7.557  1.00 48.53  ? 119 THR D OG1 1 
ATOM 10893 C CG2 . THR D 2 119 ? 11.809  44.030  -9.736  1.00 56.04  ? 119 THR D CG2 1 
ATOM 10894 N N   . VAL D 2 120 ? 14.970  43.115  -9.378  1.00 62.22  ? 120 VAL D N   1 
ATOM 10895 C CA  . VAL D 2 120 ? 16.145  43.458  -10.160 1.00 60.23  ? 120 VAL D CA  1 
ATOM 10896 C C   . VAL D 2 120 ? 15.710  43.473  -11.618 1.00 56.91  ? 120 VAL D C   1 
ATOM 10897 O O   . VAL D 2 120 ? 15.447  42.430  -12.200 1.00 54.24  ? 120 VAL D O   1 
ATOM 10898 C CB  . VAL D 2 120 ? 17.355  42.523  -9.946  1.00 64.15  ? 120 VAL D CB  1 
ATOM 10899 C CG1 . VAL D 2 120 ? 18.554  42.902  -10.814 1.00 66.45  ? 120 VAL D CG1 1 
ATOM 10900 C CG2 . VAL D 2 120 ? 17.791  42.480  -8.489  1.00 65.31  ? 120 VAL D CG2 1 
ATOM 10901 N N   . SER D 2 121 ? 15.596  44.683  -12.167 1.00 63.70  ? 121 SER D N   1 
ATOM 10902 C CA  . SER D 2 121 ? 15.563  44.894  -13.602 1.00 67.13  ? 121 SER D CA  1 
ATOM 10903 C C   . SER D 2 121 ? 16.204  46.238  -13.903 1.00 69.94  ? 121 SER D C   1 
ATOM 10904 O O   . SER D 2 121 ? 16.415  47.049  -13.003 1.00 67.96  ? 121 SER D O   1 
ATOM 10905 C CB  . SER D 2 121 ? 14.161  44.828  -14.144 1.00 68.37  ? 121 SER D CB  1 
ATOM 10906 O OG  . SER D 2 121 ? 13.343  45.836  -13.569 1.00 66.38  ? 121 SER D OG  1 
ATOM 10907 N N   . SER D 2 122 ? 16.549  46.443  -15.173 1.00 84.13  ? 122 SER D N   1 
ATOM 10908 C CA  . SER D 2 122 ? 16.939  47.762  -15.640 1.00 87.68  ? 122 SER D CA  1 
ATOM 10909 C C   . SER D 2 122 ? 15.679  48.486  -16.149 1.00 91.10  ? 122 SER D C   1 
ATOM 10910 O O   . SER D 2 122 ? 14.572  47.913  -15.954 1.00 83.39  ? 122 SER D O   1 
ATOM 10911 C CB  . SER D 2 122 ? 18.096  47.710  -16.651 1.00 80.91  ? 122 SER D CB  1 
ATOM 10912 O OG  . SER D 2 122 ? 18.436  46.388  -17.061 1.00 72.88  ? 122 SER D OG  1 
ATOM 10913 O OXT . SER D 2 122 ? 15.830  49.621  -16.657 1.00 106.08 ? 122 SER D OXT 1 
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