data_8Y9L
# 
_entry.id   8Y9L 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Y9L         pdb_00008y9l 10.2210/pdb8y9l/pdb 
WWPDB D_1300045221 ?            ?                   
EMDB  EMD-39082    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-19 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Y9L 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cas12h1-crRNA binary complex' 
_pdbx_database_related.db_id          EMD-39082 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              ouyangsy@fjnu.edu.cn 
_pdbx_contact_author.name_first         Songying 
_pdbx_contact_author.name_last          Ouyang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1120-1524 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zheng, W.W.' 1 ? 
'Liu, M.X.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Signal Transduct Target Ther' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2059-3635 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            10 
_citation.language                  ? 
_citation.page_first                66 
_citation.page_last                 66 
_citation.title                     
'Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41392-025-02147-5 
_citation.pdbx_database_id_PubMed   39955288 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zheng, W.'  1  ?                   
primary 'Li, H.'     2  ?                   
primary 'Liu, M.'    3  ?                   
primary 'Wei, Y.'    4  ?                   
primary 'Liu, B.'    5  ?                   
primary 'Li, Z.'     6  ?                   
primary 'Xiong, C.'  7  ?                   
primary 'Huang, S.'  8  ?                   
primary 'Hu, C.'     9  0000-0003-4509-4840 
primary 'Ouyang, S.' 10 0000-0002-1120-1524 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Cas12h1         100025.758 1 ? ? ? ? 
2 polymer     man crRNA           20041.965  1 ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION' 24.305     1 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'   no no 
;MKVHEIPRSQLLKIKQYEGSFVEWYRDLQEDRKKFASLLFRWAAFGYAAREDDGATYISPSQALLERRLLLGDAEDVAIK
FLDVLFKGGAPSSSCYSLFYEDFALRDKAKYSGAKREFIEGLATMPLDKIIERIRQDEQLSKIPAEEWLILGAEYSPEEI
WEQVAPRIVNVDRSLGKQLRERLGIKCRRPHDAGYCKILMEVVARQLRSHNETYHEYLNQTHEMKTKVANNLTNEFDLVC
EFAEVLEEKNYGLGWYVLWQGVKQALKEQKKPTKIQIAVDQLRQPKFAGLLTAKWRALKGAYDTWKLKKRLEKRKAFPYM
PNWDNDYQIPVGLTGLGVFTLEVKRTEVVVDLKEHGKLFCSHSHYFGDLTAEKHPSRYHLKFRHKLKLRKRDSRVEPTIG
PWIEAALREITIQKKPNGVFYLGLPYALSHGIDNFQIAKRFFSAAKPDKEVINGLPSEMVVGAADLNLSNIVAPVKARIG
KGLEGPLHALDYGYGELIDGPKILTPDGPRCGELISLKRDIVEIKSAIKEFKACQREGLTMSEETTTWLSEVESPSDSPR
CMIQSRIADTSRRLNSFKYQMNKEGYQDLAEALRLLDAMDSYNSLLESYQRMHLSPGEQSPKEAKFDTKRASFRDLLRRR
VAHTIVEYFDDCDIVFFEDLDGPSDSDSRNNALVKLLSPRTLLLYIRQALEKRGIGMVEVAKDGTSQNNPISGHVGWRNK
QNKSEIYFYEDKELLVMDADEVGAMNILCRGLNHSVCPYSFVTKAPEKKNDEKKEGDYGKRVKRFLKDRYGSSNVRFLVA
SMGFVTVTTKRPKDALVGKRLYYHGGELVTHDLHNRMKDEIKYLVEKEVLARRVSLSDSTIKSYKSFAHV
;
;MKVHEIPRSQLLKIKQYEGSFVEWYRDLQEDRKKFASLLFRWAAFGYAAREDDGATYISPSQALLERRLLLGDAEDVAIK
FLDVLFKGGAPSSSCYSLFYEDFALRDKAKYSGAKREFIEGLATMPLDKIIERIRQDEQLSKIPAEEWLILGAEYSPEEI
WEQVAPRIVNVDRSLGKQLRERLGIKCRRPHDAGYCKILMEVVARQLRSHNETYHEYLNQTHEMKTKVANNLTNEFDLVC
EFAEVLEEKNYGLGWYVLWQGVKQALKEQKKPTKIQIAVDQLRQPKFAGLLTAKWRALKGAYDTWKLKKRLEKRKAFPYM
PNWDNDYQIPVGLTGLGVFTLEVKRTEVVVDLKEHGKLFCSHSHYFGDLTAEKHPSRYHLKFRHKLKLRKRDSRVEPTIG
PWIEAALREITIQKKPNGVFYLGLPYALSHGIDNFQIAKRFFSAAKPDKEVINGLPSEMVVGAADLNLSNIVAPVKARIG
KGLEGPLHALDYGYGELIDGPKILTPDGPRCGELISLKRDIVEIKSAIKEFKACQREGLTMSEETTTWLSEVESPSDSPR
CMIQSRIADTSRRLNSFKYQMNKEGYQDLAEALRLLDAMDSYNSLLESYQRMHLSPGEQSPKEAKFDTKRASFRDLLRRR
VAHTIVEYFDDCDIVFFEDLDGPSDSDSRNNALVKLLSPRTLLLYIRQALEKRGIGMVEVAKDGTSQNNPISGHVGWRNK
QNKSEIYFYEDKELLVMDADEVGAMNILCRGLNHSVCPYSFVTKAPEKKNDEKKEGDYGKRVKRFLKDRYGSSNVRFLVA
SMGFVTVTTKRPKDALVGKRLYYHGGELVTHDLHNRMKDEIKYLVEKEVLARRVSLSDSTIKSYKSFAHV
;
A ? 
2 polyribonucleotide no no GUGCUGGCCGCUCUCGCUAGAGGGAGGUCAGAGCACAUAAUAUCAAUGGAAUAUAGCAAGCU 
GUGCUGGCCGCUCUCGCUAGAGGGAGGUCAGAGCACAUAAUAUCAAUGGAAUAUAGCAAGCU B ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        'MAGNESIUM ION' 
_pdbx_entity_nonpoly.comp_id     MG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   VAL n 
1 4   HIS n 
1 5   GLU n 
1 6   ILE n 
1 7   PRO n 
1 8   ARG n 
1 9   SER n 
1 10  GLN n 
1 11  LEU n 
1 12  LEU n 
1 13  LYS n 
1 14  ILE n 
1 15  LYS n 
1 16  GLN n 
1 17  TYR n 
1 18  GLU n 
1 19  GLY n 
1 20  SER n 
1 21  PHE n 
1 22  VAL n 
1 23  GLU n 
1 24  TRP n 
1 25  TYR n 
1 26  ARG n 
1 27  ASP n 
1 28  LEU n 
1 29  GLN n 
1 30  GLU n 
1 31  ASP n 
1 32  ARG n 
1 33  LYS n 
1 34  LYS n 
1 35  PHE n 
1 36  ALA n 
1 37  SER n 
1 38  LEU n 
1 39  LEU n 
1 40  PHE n 
1 41  ARG n 
1 42  TRP n 
1 43  ALA n 
1 44  ALA n 
1 45  PHE n 
1 46  GLY n 
1 47  TYR n 
1 48  ALA n 
1 49  ALA n 
1 50  ARG n 
1 51  GLU n 
1 52  ASP n 
1 53  ASP n 
1 54  GLY n 
1 55  ALA n 
1 56  THR n 
1 57  TYR n 
1 58  ILE n 
1 59  SER n 
1 60  PRO n 
1 61  SER n 
1 62  GLN n 
1 63  ALA n 
1 64  LEU n 
1 65  LEU n 
1 66  GLU n 
1 67  ARG n 
1 68  ARG n 
1 69  LEU n 
1 70  LEU n 
1 71  LEU n 
1 72  GLY n 
1 73  ASP n 
1 74  ALA n 
1 75  GLU n 
1 76  ASP n 
1 77  VAL n 
1 78  ALA n 
1 79  ILE n 
1 80  LYS n 
1 81  PHE n 
1 82  LEU n 
1 83  ASP n 
1 84  VAL n 
1 85  LEU n 
1 86  PHE n 
1 87  LYS n 
1 88  GLY n 
1 89  GLY n 
1 90  ALA n 
1 91  PRO n 
1 92  SER n 
1 93  SER n 
1 94  SER n 
1 95  CYS n 
1 96  TYR n 
1 97  SER n 
1 98  LEU n 
1 99  PHE n 
1 100 TYR n 
1 101 GLU n 
1 102 ASP n 
1 103 PHE n 
1 104 ALA n 
1 105 LEU n 
1 106 ARG n 
1 107 ASP n 
1 108 LYS n 
1 109 ALA n 
1 110 LYS n 
1 111 TYR n 
1 112 SER n 
1 113 GLY n 
1 114 ALA n 
1 115 LYS n 
1 116 ARG n 
1 117 GLU n 
1 118 PHE n 
1 119 ILE n 
1 120 GLU n 
1 121 GLY n 
1 122 LEU n 
1 123 ALA n 
1 124 THR n 
1 125 MET n 
1 126 PRO n 
1 127 LEU n 
1 128 ASP n 
1 129 LYS n 
1 130 ILE n 
1 131 ILE n 
1 132 GLU n 
1 133 ARG n 
1 134 ILE n 
1 135 ARG n 
1 136 GLN n 
1 137 ASP n 
1 138 GLU n 
1 139 GLN n 
1 140 LEU n 
1 141 SER n 
1 142 LYS n 
1 143 ILE n 
1 144 PRO n 
1 145 ALA n 
1 146 GLU n 
1 147 GLU n 
1 148 TRP n 
1 149 LEU n 
1 150 ILE n 
1 151 LEU n 
1 152 GLY n 
1 153 ALA n 
1 154 GLU n 
1 155 TYR n 
1 156 SER n 
1 157 PRO n 
1 158 GLU n 
1 159 GLU n 
1 160 ILE n 
1 161 TRP n 
1 162 GLU n 
1 163 GLN n 
1 164 VAL n 
1 165 ALA n 
1 166 PRO n 
1 167 ARG n 
1 168 ILE n 
1 169 VAL n 
1 170 ASN n 
1 171 VAL n 
1 172 ASP n 
1 173 ARG n 
1 174 SER n 
1 175 LEU n 
1 176 GLY n 
1 177 LYS n 
1 178 GLN n 
1 179 LEU n 
1 180 ARG n 
1 181 GLU n 
1 182 ARG n 
1 183 LEU n 
1 184 GLY n 
1 185 ILE n 
1 186 LYS n 
1 187 CYS n 
1 188 ARG n 
1 189 ARG n 
1 190 PRO n 
1 191 HIS n 
1 192 ASP n 
1 193 ALA n 
1 194 GLY n 
1 195 TYR n 
1 196 CYS n 
1 197 LYS n 
1 198 ILE n 
1 199 LEU n 
1 200 MET n 
1 201 GLU n 
1 202 VAL n 
1 203 VAL n 
1 204 ALA n 
1 205 ARG n 
1 206 GLN n 
1 207 LEU n 
1 208 ARG n 
1 209 SER n 
1 210 HIS n 
1 211 ASN n 
1 212 GLU n 
1 213 THR n 
1 214 TYR n 
1 215 HIS n 
1 216 GLU n 
1 217 TYR n 
1 218 LEU n 
1 219 ASN n 
1 220 GLN n 
1 221 THR n 
1 222 HIS n 
1 223 GLU n 
1 224 MET n 
1 225 LYS n 
1 226 THR n 
1 227 LYS n 
1 228 VAL n 
1 229 ALA n 
1 230 ASN n 
1 231 ASN n 
1 232 LEU n 
1 233 THR n 
1 234 ASN n 
1 235 GLU n 
1 236 PHE n 
1 237 ASP n 
1 238 LEU n 
1 239 VAL n 
1 240 CYS n 
1 241 GLU n 
1 242 PHE n 
1 243 ALA n 
1 244 GLU n 
1 245 VAL n 
1 246 LEU n 
1 247 GLU n 
1 248 GLU n 
1 249 LYS n 
1 250 ASN n 
1 251 TYR n 
1 252 GLY n 
1 253 LEU n 
1 254 GLY n 
1 255 TRP n 
1 256 TYR n 
1 257 VAL n 
1 258 LEU n 
1 259 TRP n 
1 260 GLN n 
1 261 GLY n 
1 262 VAL n 
1 263 LYS n 
1 264 GLN n 
1 265 ALA n 
1 266 LEU n 
1 267 LYS n 
1 268 GLU n 
1 269 GLN n 
1 270 LYS n 
1 271 LYS n 
1 272 PRO n 
1 273 THR n 
1 274 LYS n 
1 275 ILE n 
1 276 GLN n 
1 277 ILE n 
1 278 ALA n 
1 279 VAL n 
1 280 ASP n 
1 281 GLN n 
1 282 LEU n 
1 283 ARG n 
1 284 GLN n 
1 285 PRO n 
1 286 LYS n 
1 287 PHE n 
1 288 ALA n 
1 289 GLY n 
1 290 LEU n 
1 291 LEU n 
1 292 THR n 
1 293 ALA n 
1 294 LYS n 
1 295 TRP n 
1 296 ARG n 
1 297 ALA n 
1 298 LEU n 
1 299 LYS n 
1 300 GLY n 
1 301 ALA n 
1 302 TYR n 
1 303 ASP n 
1 304 THR n 
1 305 TRP n 
1 306 LYS n 
1 307 LEU n 
1 308 LYS n 
1 309 LYS n 
1 310 ARG n 
1 311 LEU n 
1 312 GLU n 
1 313 LYS n 
1 314 ARG n 
1 315 LYS n 
1 316 ALA n 
1 317 PHE n 
1 318 PRO n 
1 319 TYR n 
1 320 MET n 
1 321 PRO n 
1 322 ASN n 
1 323 TRP n 
1 324 ASP n 
1 325 ASN n 
1 326 ASP n 
1 327 TYR n 
1 328 GLN n 
1 329 ILE n 
1 330 PRO n 
1 331 VAL n 
1 332 GLY n 
1 333 LEU n 
1 334 THR n 
1 335 GLY n 
1 336 LEU n 
1 337 GLY n 
1 338 VAL n 
1 339 PHE n 
1 340 THR n 
1 341 LEU n 
1 342 GLU n 
1 343 VAL n 
1 344 LYS n 
1 345 ARG n 
1 346 THR n 
1 347 GLU n 
1 348 VAL n 
1 349 VAL n 
1 350 VAL n 
1 351 ASP n 
1 352 LEU n 
1 353 LYS n 
1 354 GLU n 
1 355 HIS n 
1 356 GLY n 
1 357 LYS n 
1 358 LEU n 
1 359 PHE n 
1 360 CYS n 
1 361 SER n 
1 362 HIS n 
1 363 SER n 
1 364 HIS n 
1 365 TYR n 
1 366 PHE n 
1 367 GLY n 
1 368 ASP n 
1 369 LEU n 
1 370 THR n 
1 371 ALA n 
1 372 GLU n 
1 373 LYS n 
1 374 HIS n 
1 375 PRO n 
1 376 SER n 
1 377 ARG n 
1 378 TYR n 
1 379 HIS n 
1 380 LEU n 
1 381 LYS n 
1 382 PHE n 
1 383 ARG n 
1 384 HIS n 
1 385 LYS n 
1 386 LEU n 
1 387 LYS n 
1 388 LEU n 
1 389 ARG n 
1 390 LYS n 
1 391 ARG n 
1 392 ASP n 
1 393 SER n 
1 394 ARG n 
1 395 VAL n 
1 396 GLU n 
1 397 PRO n 
1 398 THR n 
1 399 ILE n 
1 400 GLY n 
1 401 PRO n 
1 402 TRP n 
1 403 ILE n 
1 404 GLU n 
1 405 ALA n 
1 406 ALA n 
1 407 LEU n 
1 408 ARG n 
1 409 GLU n 
1 410 ILE n 
1 411 THR n 
1 412 ILE n 
1 413 GLN n 
1 414 LYS n 
1 415 LYS n 
1 416 PRO n 
1 417 ASN n 
1 418 GLY n 
1 419 VAL n 
1 420 PHE n 
1 421 TYR n 
1 422 LEU n 
1 423 GLY n 
1 424 LEU n 
1 425 PRO n 
1 426 TYR n 
1 427 ALA n 
1 428 LEU n 
1 429 SER n 
1 430 HIS n 
1 431 GLY n 
1 432 ILE n 
1 433 ASP n 
1 434 ASN n 
1 435 PHE n 
1 436 GLN n 
1 437 ILE n 
1 438 ALA n 
1 439 LYS n 
1 440 ARG n 
1 441 PHE n 
1 442 PHE n 
1 443 SER n 
1 444 ALA n 
1 445 ALA n 
1 446 LYS n 
1 447 PRO n 
1 448 ASP n 
1 449 LYS n 
1 450 GLU n 
1 451 VAL n 
1 452 ILE n 
1 453 ASN n 
1 454 GLY n 
1 455 LEU n 
1 456 PRO n 
1 457 SER n 
1 458 GLU n 
1 459 MET n 
1 460 VAL n 
1 461 VAL n 
1 462 GLY n 
1 463 ALA n 
1 464 ALA n 
1 465 ASP n 
1 466 LEU n 
1 467 ASN n 
1 468 LEU n 
1 469 SER n 
1 470 ASN n 
1 471 ILE n 
1 472 VAL n 
1 473 ALA n 
1 474 PRO n 
1 475 VAL n 
1 476 LYS n 
1 477 ALA n 
1 478 ARG n 
1 479 ILE n 
1 480 GLY n 
1 481 LYS n 
1 482 GLY n 
1 483 LEU n 
1 484 GLU n 
1 485 GLY n 
1 486 PRO n 
1 487 LEU n 
1 488 HIS n 
1 489 ALA n 
1 490 LEU n 
1 491 ASP n 
1 492 TYR n 
1 493 GLY n 
1 494 TYR n 
1 495 GLY n 
1 496 GLU n 
1 497 LEU n 
1 498 ILE n 
1 499 ASP n 
1 500 GLY n 
1 501 PRO n 
1 502 LYS n 
1 503 ILE n 
1 504 LEU n 
1 505 THR n 
1 506 PRO n 
1 507 ASP n 
1 508 GLY n 
1 509 PRO n 
1 510 ARG n 
1 511 CYS n 
1 512 GLY n 
1 513 GLU n 
1 514 LEU n 
1 515 ILE n 
1 516 SER n 
1 517 LEU n 
1 518 LYS n 
1 519 ARG n 
1 520 ASP n 
1 521 ILE n 
1 522 VAL n 
1 523 GLU n 
1 524 ILE n 
1 525 LYS n 
1 526 SER n 
1 527 ALA n 
1 528 ILE n 
1 529 LYS n 
1 530 GLU n 
1 531 PHE n 
1 532 LYS n 
1 533 ALA n 
1 534 CYS n 
1 535 GLN n 
1 536 ARG n 
1 537 GLU n 
1 538 GLY n 
1 539 LEU n 
1 540 THR n 
1 541 MET n 
1 542 SER n 
1 543 GLU n 
1 544 GLU n 
1 545 THR n 
1 546 THR n 
1 547 THR n 
1 548 TRP n 
1 549 LEU n 
1 550 SER n 
1 551 GLU n 
1 552 VAL n 
1 553 GLU n 
1 554 SER n 
1 555 PRO n 
1 556 SER n 
1 557 ASP n 
1 558 SER n 
1 559 PRO n 
1 560 ARG n 
1 561 CYS n 
1 562 MET n 
1 563 ILE n 
1 564 GLN n 
1 565 SER n 
1 566 ARG n 
1 567 ILE n 
1 568 ALA n 
1 569 ASP n 
1 570 THR n 
1 571 SER n 
1 572 ARG n 
1 573 ARG n 
1 574 LEU n 
1 575 ASN n 
1 576 SER n 
1 577 PHE n 
1 578 LYS n 
1 579 TYR n 
1 580 GLN n 
1 581 MET n 
1 582 ASN n 
1 583 LYS n 
1 584 GLU n 
1 585 GLY n 
1 586 TYR n 
1 587 GLN n 
1 588 ASP n 
1 589 LEU n 
1 590 ALA n 
1 591 GLU n 
1 592 ALA n 
1 593 LEU n 
1 594 ARG n 
1 595 LEU n 
1 596 LEU n 
1 597 ASP n 
1 598 ALA n 
1 599 MET n 
1 600 ASP n 
1 601 SER n 
1 602 TYR n 
1 603 ASN n 
1 604 SER n 
1 605 LEU n 
1 606 LEU n 
1 607 GLU n 
1 608 SER n 
1 609 TYR n 
1 610 GLN n 
1 611 ARG n 
1 612 MET n 
1 613 HIS n 
1 614 LEU n 
1 615 SER n 
1 616 PRO n 
1 617 GLY n 
1 618 GLU n 
1 619 GLN n 
1 620 SER n 
1 621 PRO n 
1 622 LYS n 
1 623 GLU n 
1 624 ALA n 
1 625 LYS n 
1 626 PHE n 
1 627 ASP n 
1 628 THR n 
1 629 LYS n 
1 630 ARG n 
1 631 ALA n 
1 632 SER n 
1 633 PHE n 
1 634 ARG n 
1 635 ASP n 
1 636 LEU n 
1 637 LEU n 
1 638 ARG n 
1 639 ARG n 
1 640 ARG n 
1 641 VAL n 
1 642 ALA n 
1 643 HIS n 
1 644 THR n 
1 645 ILE n 
1 646 VAL n 
1 647 GLU n 
1 648 TYR n 
1 649 PHE n 
1 650 ASP n 
1 651 ASP n 
1 652 CYS n 
1 653 ASP n 
1 654 ILE n 
1 655 VAL n 
1 656 PHE n 
1 657 PHE n 
1 658 GLU n 
1 659 ASP n 
1 660 LEU n 
1 661 ASP n 
1 662 GLY n 
1 663 PRO n 
1 664 SER n 
1 665 ASP n 
1 666 SER n 
1 667 ASP n 
1 668 SER n 
1 669 ARG n 
1 670 ASN n 
1 671 ASN n 
1 672 ALA n 
1 673 LEU n 
1 674 VAL n 
1 675 LYS n 
1 676 LEU n 
1 677 LEU n 
1 678 SER n 
1 679 PRO n 
1 680 ARG n 
1 681 THR n 
1 682 LEU n 
1 683 LEU n 
1 684 LEU n 
1 685 TYR n 
1 686 ILE n 
1 687 ARG n 
1 688 GLN n 
1 689 ALA n 
1 690 LEU n 
1 691 GLU n 
1 692 LYS n 
1 693 ARG n 
1 694 GLY n 
1 695 ILE n 
1 696 GLY n 
1 697 MET n 
1 698 VAL n 
1 699 GLU n 
1 700 VAL n 
1 701 ALA n 
1 702 LYS n 
1 703 ASP n 
1 704 GLY n 
1 705 THR n 
1 706 SER n 
1 707 GLN n 
1 708 ASN n 
1 709 ASN n 
1 710 PRO n 
1 711 ILE n 
1 712 SER n 
1 713 GLY n 
1 714 HIS n 
1 715 VAL n 
1 716 GLY n 
1 717 TRP n 
1 718 ARG n 
1 719 ASN n 
1 720 LYS n 
1 721 GLN n 
1 722 ASN n 
1 723 LYS n 
1 724 SER n 
1 725 GLU n 
1 726 ILE n 
1 727 TYR n 
1 728 PHE n 
1 729 TYR n 
1 730 GLU n 
1 731 ASP n 
1 732 LYS n 
1 733 GLU n 
1 734 LEU n 
1 735 LEU n 
1 736 VAL n 
1 737 MET n 
1 738 ASP n 
1 739 ALA n 
1 740 ASP n 
1 741 GLU n 
1 742 VAL n 
1 743 GLY n 
1 744 ALA n 
1 745 MET n 
1 746 ASN n 
1 747 ILE n 
1 748 LEU n 
1 749 CYS n 
1 750 ARG n 
1 751 GLY n 
1 752 LEU n 
1 753 ASN n 
1 754 HIS n 
1 755 SER n 
1 756 VAL n 
1 757 CYS n 
1 758 PRO n 
1 759 TYR n 
1 760 SER n 
1 761 PHE n 
1 762 VAL n 
1 763 THR n 
1 764 LYS n 
1 765 ALA n 
1 766 PRO n 
1 767 GLU n 
1 768 LYS n 
1 769 LYS n 
1 770 ASN n 
1 771 ASP n 
1 772 GLU n 
1 773 LYS n 
1 774 LYS n 
1 775 GLU n 
1 776 GLY n 
1 777 ASP n 
1 778 TYR n 
1 779 GLY n 
1 780 LYS n 
1 781 ARG n 
1 782 VAL n 
1 783 LYS n 
1 784 ARG n 
1 785 PHE n 
1 786 LEU n 
1 787 LYS n 
1 788 ASP n 
1 789 ARG n 
1 790 TYR n 
1 791 GLY n 
1 792 SER n 
1 793 SER n 
1 794 ASN n 
1 795 VAL n 
1 796 ARG n 
1 797 PHE n 
1 798 LEU n 
1 799 VAL n 
1 800 ALA n 
1 801 SER n 
1 802 MET n 
1 803 GLY n 
1 804 PHE n 
1 805 VAL n 
1 806 THR n 
1 807 VAL n 
1 808 THR n 
1 809 THR n 
1 810 LYS n 
1 811 ARG n 
1 812 PRO n 
1 813 LYS n 
1 814 ASP n 
1 815 ALA n 
1 816 LEU n 
1 817 VAL n 
1 818 GLY n 
1 819 LYS n 
1 820 ARG n 
1 821 LEU n 
1 822 TYR n 
1 823 TYR n 
1 824 HIS n 
1 825 GLY n 
1 826 GLY n 
1 827 GLU n 
1 828 LEU n 
1 829 VAL n 
1 830 THR n 
1 831 HIS n 
1 832 ASP n 
1 833 LEU n 
1 834 HIS n 
1 835 ASN n 
1 836 ARG n 
1 837 MET n 
1 838 LYS n 
1 839 ASP n 
1 840 GLU n 
1 841 ILE n 
1 842 LYS n 
1 843 TYR n 
1 844 LEU n 
1 845 VAL n 
1 846 GLU n 
1 847 LYS n 
1 848 GLU n 
1 849 VAL n 
1 850 LEU n 
1 851 ALA n 
1 852 ARG n 
1 853 ARG n 
1 854 VAL n 
1 855 SER n 
1 856 LEU n 
1 857 SER n 
1 858 ASP n 
1 859 SER n 
1 860 THR n 
1 861 ILE n 
1 862 LYS n 
1 863 SER n 
1 864 TYR n 
1 865 LYS n 
1 866 SER n 
1 867 PHE n 
1 868 ALA n 
1 869 HIS n 
1 870 VAL n 
2 1   G   n 
2 2   U   n 
2 3   G   n 
2 4   C   n 
2 5   U   n 
2 6   G   n 
2 7   G   n 
2 8   C   n 
2 9   C   n 
2 10  G   n 
2 11  C   n 
2 12  U   n 
2 13  C   n 
2 14  U   n 
2 15  C   n 
2 16  G   n 
2 17  C   n 
2 18  U   n 
2 19  A   n 
2 20  G   n 
2 21  A   n 
2 22  G   n 
2 23  G   n 
2 24  G   n 
2 25  A   n 
2 26  G   n 
2 27  G   n 
2 28  U   n 
2 29  C   n 
2 30  A   n 
2 31  G   n 
2 32  A   n 
2 33  G   n 
2 34  C   n 
2 35  A   n 
2 36  C   n 
2 37  A   n 
2 38  U   n 
2 39  A   n 
2 40  A   n 
2 41  U   n 
2 42  A   n 
2 43  U   n 
2 44  C   n 
2 45  A   n 
2 46  A   n 
2 47  U   n 
2 48  G   n 
2 49  G   n 
2 50  A   n 
2 51  A   n 
2 52  U   n 
2 53  A   n 
2 54  U   n 
2 55  A   n 
2 56  G   n 
2 57  C   n 
2 58  A   n 
2 59  A   n 
2 60  G   n 
2 61  C   n 
2 62  U   n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 870 ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli BL21(DE3)' 469008 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 62  ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli BL21(DE3)' 469008 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O8 P'  323.197 
CYS 'L-peptide linking' y CYSTEINE                     ? 'C3 H7 N O2 S'    121.158 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'   149.211 
MG  non-polymer         . 'MAGNESIUM ION'              ? 'Mg 2'            24.305  
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'     181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"   ? 'C9 H13 N2 O9 P'  324.181 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   LYS 2   2   ?   ?   ?   A . n 
A 1 3   VAL 3   3   ?   ?   ?   A . n 
A 1 4   HIS 4   4   4   HIS HIS A . n 
A 1 5   GLU 5   5   5   GLU GLU A . n 
A 1 6   ILE 6   6   6   ILE ILE A . n 
A 1 7   PRO 7   7   7   PRO PRO A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  GLN 10  10  10  GLN GLN A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  LYS 13  13  13  LYS LYS A . n 
A 1 14  ILE 14  14  14  ILE ILE A . n 
A 1 15  LYS 15  15  15  LYS LYS A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  TYR 17  17  17  TYR TYR A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  GLY 19  19  19  GLY GLY A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  PHE 21  21  21  PHE PHE A . n 
A 1 22  VAL 22  22  22  VAL VAL A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  TRP 24  24  24  TRP TRP A . n 
A 1 25  TYR 25  25  25  TYR TYR A . n 
A 1 26  ARG 26  26  26  ARG ARG A . n 
A 1 27  ASP 27  27  27  ASP ASP A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  GLN 29  29  29  GLN GLN A . n 
A 1 30  GLU 30  30  30  GLU GLU A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  ARG 32  32  32  ARG ARG A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  LYS 34  34  34  LYS LYS A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  LEU 38  38  38  LEU LEU A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  TRP 42  42  42  TRP TRP A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  TYR 47  47  47  TYR TYR A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  ARG 50  50  50  ARG ARG A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  THR 56  56  56  THR THR A . n 
A 1 57  TYR 57  57  57  TYR TYR A . n 
A 1 58  ILE 58  58  58  ILE ILE A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  PRO 60  60  60  PRO PRO A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  ALA 63  63  63  ALA ALA A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  GLU 66  66  66  GLU GLU A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  LEU 69  69  69  LEU LEU A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  GLU 75  75  75  GLU GLU A . n 
A 1 76  ASP 76  76  76  ASP ASP A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  LYS 80  80  80  LYS LYS A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  ASP 83  83  83  ASP ASP A . n 
A 1 84  VAL 84  84  84  VAL VAL A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  PHE 86  86  86  PHE PHE A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  GLY 88  88  88  GLY GLY A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  SER 93  93  93  SER SER A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  CYS 95  95  95  CYS CYS A . n 
A 1 96  TYR 96  96  96  TYR TYR A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  LEU 98  98  98  LEU LEU A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 TYR 100 100 100 TYR TYR A . n 
A 1 101 GLU 101 101 101 GLU GLU A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 PHE 103 103 ?   ?   ?   A . n 
A 1 104 ALA 104 104 ?   ?   ?   A . n 
A 1 105 LEU 105 105 ?   ?   ?   A . n 
A 1 106 ARG 106 106 ?   ?   ?   A . n 
A 1 107 ASP 107 107 ?   ?   ?   A . n 
A 1 108 LYS 108 108 ?   ?   ?   A . n 
A 1 109 ALA 109 109 ?   ?   ?   A . n 
A 1 110 LYS 110 110 ?   ?   ?   A . n 
A 1 111 TYR 111 111 ?   ?   ?   A . n 
A 1 112 SER 112 112 ?   ?   ?   A . n 
A 1 113 GLY 113 113 ?   ?   ?   A . n 
A 1 114 ALA 114 114 ?   ?   ?   A . n 
A 1 115 LYS 115 115 ?   ?   ?   A . n 
A 1 116 ARG 116 116 ?   ?   ?   A . n 
A 1 117 GLU 117 117 ?   ?   ?   A . n 
A 1 118 PHE 118 118 ?   ?   ?   A . n 
A 1 119 ILE 119 119 ?   ?   ?   A . n 
A 1 120 GLU 120 120 ?   ?   ?   A . n 
A 1 121 GLY 121 121 ?   ?   ?   A . n 
A 1 122 LEU 122 122 ?   ?   ?   A . n 
A 1 123 ALA 123 123 ?   ?   ?   A . n 
A 1 124 THR 124 124 ?   ?   ?   A . n 
A 1 125 MET 125 125 ?   ?   ?   A . n 
A 1 126 PRO 126 126 ?   ?   ?   A . n 
A 1 127 LEU 127 127 ?   ?   ?   A . n 
A 1 128 ASP 128 128 ?   ?   ?   A . n 
A 1 129 LYS 129 129 ?   ?   ?   A . n 
A 1 130 ILE 130 130 ?   ?   ?   A . n 
A 1 131 ILE 131 131 ?   ?   ?   A . n 
A 1 132 GLU 132 132 ?   ?   ?   A . n 
A 1 133 ARG 133 133 ?   ?   ?   A . n 
A 1 134 ILE 134 134 ?   ?   ?   A . n 
A 1 135 ARG 135 135 ?   ?   ?   A . n 
A 1 136 GLN 136 136 ?   ?   ?   A . n 
A 1 137 ASP 137 137 ?   ?   ?   A . n 
A 1 138 GLU 138 138 ?   ?   ?   A . n 
A 1 139 GLN 139 139 ?   ?   ?   A . n 
A 1 140 LEU 140 140 ?   ?   ?   A . n 
A 1 141 SER 141 141 ?   ?   ?   A . n 
A 1 142 LYS 142 142 ?   ?   ?   A . n 
A 1 143 ILE 143 143 ?   ?   ?   A . n 
A 1 144 PRO 144 144 ?   ?   ?   A . n 
A 1 145 ALA 145 145 ?   ?   ?   A . n 
A 1 146 GLU 146 146 ?   ?   ?   A . n 
A 1 147 GLU 147 147 ?   ?   ?   A . n 
A 1 148 TRP 148 148 ?   ?   ?   A . n 
A 1 149 LEU 149 149 ?   ?   ?   A . n 
A 1 150 ILE 150 150 ?   ?   ?   A . n 
A 1 151 LEU 151 151 ?   ?   ?   A . n 
A 1 152 GLY 152 152 ?   ?   ?   A . n 
A 1 153 ALA 153 153 ?   ?   ?   A . n 
A 1 154 GLU 154 154 ?   ?   ?   A . n 
A 1 155 TYR 155 155 ?   ?   ?   A . n 
A 1 156 SER 156 156 ?   ?   ?   A . n 
A 1 157 PRO 157 157 ?   ?   ?   A . n 
A 1 158 GLU 158 158 ?   ?   ?   A . n 
A 1 159 GLU 159 159 ?   ?   ?   A . n 
A 1 160 ILE 160 160 ?   ?   ?   A . n 
A 1 161 TRP 161 161 ?   ?   ?   A . n 
A 1 162 GLU 162 162 ?   ?   ?   A . n 
A 1 163 GLN 163 163 ?   ?   ?   A . n 
A 1 164 VAL 164 164 ?   ?   ?   A . n 
A 1 165 ALA 165 165 ?   ?   ?   A . n 
A 1 166 PRO 166 166 ?   ?   ?   A . n 
A 1 167 ARG 167 167 ?   ?   ?   A . n 
A 1 168 ILE 168 168 ?   ?   ?   A . n 
A 1 169 VAL 169 169 ?   ?   ?   A . n 
A 1 170 ASN 170 170 ?   ?   ?   A . n 
A 1 171 VAL 171 171 ?   ?   ?   A . n 
A 1 172 ASP 172 172 ?   ?   ?   A . n 
A 1 173 ARG 173 173 ?   ?   ?   A . n 
A 1 174 SER 174 174 174 SER SER A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 LYS 177 177 177 LYS LYS A . n 
A 1 178 GLN 178 178 178 GLN GLN A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 ARG 180 180 180 ARG ARG A . n 
A 1 181 GLU 181 181 181 GLU GLU A . n 
A 1 182 ARG 182 182 182 ARG ARG A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 GLY 184 184 184 GLY GLY A . n 
A 1 185 ILE 185 185 185 ILE ILE A . n 
A 1 186 LYS 186 186 186 LYS LYS A . n 
A 1 187 CYS 187 187 187 CYS CYS A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 PRO 190 190 190 PRO PRO A . n 
A 1 191 HIS 191 191 191 HIS HIS A . n 
A 1 192 ASP 192 192 192 ASP ASP A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 GLY 194 194 194 GLY GLY A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 CYS 196 196 196 CYS CYS A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 ILE 198 198 198 ILE ILE A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 MET 200 200 200 MET MET A . n 
A 1 201 GLU 201 201 201 GLU GLU A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 VAL 203 203 203 VAL VAL A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 ARG 205 205 205 ARG ARG A . n 
A 1 206 GLN 206 206 206 GLN GLN A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 ARG 208 208 208 ARG ARG A . n 
A 1 209 SER 209 209 209 SER SER A . n 
A 1 210 HIS 210 210 210 HIS HIS A . n 
A 1 211 ASN 211 211 211 ASN ASN A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 TYR 214 214 214 TYR TYR A . n 
A 1 215 HIS 215 215 215 HIS HIS A . n 
A 1 216 GLU 216 216 216 GLU GLU A . n 
A 1 217 TYR 217 217 217 TYR TYR A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 ASN 219 219 219 ASN ASN A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 THR 221 221 221 THR THR A . n 
A 1 222 HIS 222 222 222 HIS HIS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 MET 224 224 224 MET MET A . n 
A 1 225 LYS 225 225 225 LYS LYS A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 ALA 229 229 229 ALA ALA A . n 
A 1 230 ASN 230 230 230 ASN ASN A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 ASN 234 234 234 ASN ASN A . n 
A 1 235 GLU 235 235 235 GLU GLU A . n 
A 1 236 PHE 236 236 236 PHE PHE A . n 
A 1 237 ASP 237 237 237 ASP ASP A . n 
A 1 238 LEU 238 238 238 LEU LEU A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 CYS 240 240 240 CYS CYS A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 PHE 242 242 242 PHE PHE A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 GLU 247 247 247 GLU GLU A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 TYR 251 251 251 TYR TYR A . n 
A 1 252 GLY 252 252 252 GLY GLY A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 GLY 254 254 254 GLY GLY A . n 
A 1 255 TRP 255 255 255 TRP TRP A . n 
A 1 256 TYR 256 256 256 TYR TYR A . n 
A 1 257 VAL 257 257 257 VAL VAL A . n 
A 1 258 LEU 258 258 258 LEU LEU A . n 
A 1 259 TRP 259 259 259 TRP TRP A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 GLY 261 261 261 GLY GLY A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 LYS 263 263 263 LYS LYS A . n 
A 1 264 GLN 264 264 264 GLN GLN A . n 
A 1 265 ALA 265 265 265 ALA ALA A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 LYS 267 267 267 LYS LYS A . n 
A 1 268 GLU 268 268 268 GLU GLU A . n 
A 1 269 GLN 269 269 269 GLN GLN A . n 
A 1 270 LYS 270 270 270 LYS LYS A . n 
A 1 271 LYS 271 271 271 LYS LYS A . n 
A 1 272 PRO 272 272 272 PRO PRO A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 LYS 274 274 274 LYS LYS A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 GLN 276 276 276 GLN GLN A . n 
A 1 277 ILE 277 277 277 ILE ILE A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 VAL 279 279 279 VAL VAL A . n 
A 1 280 ASP 280 280 280 ASP ASP A . n 
A 1 281 GLN 281 281 281 GLN GLN A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 ARG 283 283 283 ARG ARG A . n 
A 1 284 GLN 284 284 284 GLN GLN A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 ALA 288 288 288 ALA ALA A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 LYS 294 294 294 LYS LYS A . n 
A 1 295 TRP 295 295 295 TRP TRP A . n 
A 1 296 ARG 296 296 296 ARG ARG A . n 
A 1 297 ALA 297 297 297 ALA ALA A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 LYS 299 299 299 LYS LYS A . n 
A 1 300 GLY 300 300 300 GLY GLY A . n 
A 1 301 ALA 301 301 301 ALA ALA A . n 
A 1 302 TYR 302 302 302 TYR TYR A . n 
A 1 303 ASP 303 303 303 ASP ASP A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 TRP 305 305 305 TRP TRP A . n 
A 1 306 LYS 306 306 306 LYS LYS A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 LYS 308 308 308 LYS LYS A . n 
A 1 309 LYS 309 309 309 LYS LYS A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 GLU 312 312 312 GLU GLU A . n 
A 1 313 LYS 313 313 313 LYS LYS A . n 
A 1 314 ARG 314 314 314 ARG ARG A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 PHE 317 317 317 PHE PHE A . n 
A 1 318 PRO 318 318 318 PRO PRO A . n 
A 1 319 TYR 319 319 319 TYR TYR A . n 
A 1 320 MET 320 320 320 MET MET A . n 
A 1 321 PRO 321 321 321 PRO PRO A . n 
A 1 322 ASN 322 322 322 ASN ASN A . n 
A 1 323 TRP 323 323 323 TRP TRP A . n 
A 1 324 ASP 324 324 324 ASP ASP A . n 
A 1 325 ASN 325 325 325 ASN ASN A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 TYR 327 327 327 TYR TYR A . n 
A 1 328 GLN 328 328 328 GLN GLN A . n 
A 1 329 ILE 329 329 329 ILE ILE A . n 
A 1 330 PRO 330 330 330 PRO PRO A . n 
A 1 331 VAL 331 331 331 VAL VAL A . n 
A 1 332 GLY 332 332 332 GLY GLY A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 THR 334 334 334 THR THR A . n 
A 1 335 GLY 335 335 335 GLY GLY A . n 
A 1 336 LEU 336 336 336 LEU LEU A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 VAL 338 338 338 VAL VAL A . n 
A 1 339 PHE 339 339 339 PHE PHE A . n 
A 1 340 THR 340 340 340 THR THR A . n 
A 1 341 LEU 341 341 341 LEU LEU A . n 
A 1 342 GLU 342 342 342 GLU GLU A . n 
A 1 343 VAL 343 343 343 VAL VAL A . n 
A 1 344 LYS 344 344 344 LYS LYS A . n 
A 1 345 ARG 345 345 345 ARG ARG A . n 
A 1 346 THR 346 346 346 THR THR A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 VAL 348 348 348 VAL VAL A . n 
A 1 349 VAL 349 349 349 VAL VAL A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 ASP 351 351 351 ASP ASP A . n 
A 1 352 LEU 352 352 352 LEU LEU A . n 
A 1 353 LYS 353 353 353 LYS LYS A . n 
A 1 354 GLU 354 354 354 GLU GLU A . n 
A 1 355 HIS 355 355 355 HIS HIS A . n 
A 1 356 GLY 356 356 356 GLY GLY A . n 
A 1 357 LYS 357 357 357 LYS LYS A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 PHE 359 359 359 PHE PHE A . n 
A 1 360 CYS 360 360 360 CYS CYS A . n 
A 1 361 SER 361 361 361 SER SER A . n 
A 1 362 HIS 362 362 362 HIS HIS A . n 
A 1 363 SER 363 363 363 SER SER A . n 
A 1 364 HIS 364 364 364 HIS HIS A . n 
A 1 365 TYR 365 365 365 TYR TYR A . n 
A 1 366 PHE 366 366 366 PHE PHE A . n 
A 1 367 GLY 367 367 367 GLY GLY A . n 
A 1 368 ASP 368 368 368 ASP ASP A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 THR 370 370 370 THR THR A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 GLU 372 372 372 GLU GLU A . n 
A 1 373 LYS 373 373 373 LYS LYS A . n 
A 1 374 HIS 374 374 374 HIS HIS A . n 
A 1 375 PRO 375 375 375 PRO PRO A . n 
A 1 376 SER 376 376 376 SER SER A . n 
A 1 377 ARG 377 377 377 ARG ARG A . n 
A 1 378 TYR 378 378 378 TYR TYR A . n 
A 1 379 HIS 379 379 379 HIS HIS A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 LYS 381 381 381 LYS LYS A . n 
A 1 382 PHE 382 382 382 PHE PHE A . n 
A 1 383 ARG 383 383 383 ARG ARG A . n 
A 1 384 HIS 384 384 384 HIS HIS A . n 
A 1 385 LYS 385 385 385 LYS LYS A . n 
A 1 386 LEU 386 386 386 LEU LEU A . n 
A 1 387 LYS 387 387 387 LYS LYS A . n 
A 1 388 LEU 388 388 388 LEU LEU A . n 
A 1 389 ARG 389 389 389 ARG ARG A . n 
A 1 390 LYS 390 390 390 LYS LYS A . n 
A 1 391 ARG 391 391 391 ARG ARG A . n 
A 1 392 ASP 392 392 392 ASP ASP A . n 
A 1 393 SER 393 393 393 SER SER A . n 
A 1 394 ARG 394 394 394 ARG ARG A . n 
A 1 395 VAL 395 395 395 VAL VAL A . n 
A 1 396 GLU 396 396 396 GLU GLU A . n 
A 1 397 PRO 397 397 397 PRO PRO A . n 
A 1 398 THR 398 398 398 THR THR A . n 
A 1 399 ILE 399 399 399 ILE ILE A . n 
A 1 400 GLY 400 400 400 GLY GLY A . n 
A 1 401 PRO 401 401 401 PRO PRO A . n 
A 1 402 TRP 402 402 402 TRP TRP A . n 
A 1 403 ILE 403 403 403 ILE ILE A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 ALA 405 405 405 ALA ALA A . n 
A 1 406 ALA 406 406 406 ALA ALA A . n 
A 1 407 LEU 407 407 407 LEU LEU A . n 
A 1 408 ARG 408 408 408 ARG ARG A . n 
A 1 409 GLU 409 409 409 GLU GLU A . n 
A 1 410 ILE 410 410 410 ILE ILE A . n 
A 1 411 THR 411 411 411 THR THR A . n 
A 1 412 ILE 412 412 412 ILE ILE A . n 
A 1 413 GLN 413 413 413 GLN GLN A . n 
A 1 414 LYS 414 414 414 LYS LYS A . n 
A 1 415 LYS 415 415 415 LYS LYS A . n 
A 1 416 PRO 416 416 416 PRO PRO A . n 
A 1 417 ASN 417 417 417 ASN ASN A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 VAL 419 419 419 VAL VAL A . n 
A 1 420 PHE 420 420 420 PHE PHE A . n 
A 1 421 TYR 421 421 421 TYR TYR A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 GLY 423 423 423 GLY GLY A . n 
A 1 424 LEU 424 424 424 LEU LEU A . n 
A 1 425 PRO 425 425 425 PRO PRO A . n 
A 1 426 TYR 426 426 426 TYR TYR A . n 
A 1 427 ALA 427 427 427 ALA ALA A . n 
A 1 428 LEU 428 428 428 LEU LEU A . n 
A 1 429 SER 429 429 429 SER SER A . n 
A 1 430 HIS 430 430 430 HIS HIS A . n 
A 1 431 GLY 431 431 431 GLY GLY A . n 
A 1 432 ILE 432 432 432 ILE ILE A . n 
A 1 433 ASP 433 433 433 ASP ASP A . n 
A 1 434 ASN 434 434 434 ASN ASN A . n 
A 1 435 PHE 435 435 435 PHE PHE A . n 
A 1 436 GLN 436 436 436 GLN GLN A . n 
A 1 437 ILE 437 437 437 ILE ILE A . n 
A 1 438 ALA 438 438 438 ALA ALA A . n 
A 1 439 LYS 439 439 439 LYS LYS A . n 
A 1 440 ARG 440 440 440 ARG ARG A . n 
A 1 441 PHE 441 441 441 PHE PHE A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 SER 443 443 443 SER SER A . n 
A 1 444 ALA 444 444 444 ALA ALA A . n 
A 1 445 ALA 445 445 445 ALA ALA A . n 
A 1 446 LYS 446 446 446 LYS LYS A . n 
A 1 447 PRO 447 447 447 PRO PRO A . n 
A 1 448 ASP 448 448 448 ASP ASP A . n 
A 1 449 LYS 449 449 449 LYS LYS A . n 
A 1 450 GLU 450 450 450 GLU GLU A . n 
A 1 451 VAL 451 451 451 VAL VAL A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 ASN 453 453 453 ASN ASN A . n 
A 1 454 GLY 454 454 454 GLY GLY A . n 
A 1 455 LEU 455 455 455 LEU LEU A . n 
A 1 456 PRO 456 456 456 PRO PRO A . n 
A 1 457 SER 457 457 457 SER SER A . n 
A 1 458 GLU 458 458 458 GLU GLU A . n 
A 1 459 MET 459 459 459 MET MET A . n 
A 1 460 VAL 460 460 460 VAL VAL A . n 
A 1 461 VAL 461 461 461 VAL VAL A . n 
A 1 462 GLY 462 462 462 GLY GLY A . n 
A 1 463 ALA 463 463 463 ALA ALA A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 ASP 465 465 465 ASP ASP A . n 
A 1 466 LEU 466 466 466 LEU LEU A . n 
A 1 467 ASN 467 467 467 ASN ASN A . n 
A 1 468 LEU 468 468 468 LEU LEU A . n 
A 1 469 SER 469 469 469 SER SER A . n 
A 1 470 ASN 470 470 470 ASN ASN A . n 
A 1 471 ILE 471 471 471 ILE ILE A . n 
A 1 472 VAL 472 472 472 VAL VAL A . n 
A 1 473 ALA 473 473 473 ALA ALA A . n 
A 1 474 PRO 474 474 474 PRO PRO A . n 
A 1 475 VAL 475 475 475 VAL VAL A . n 
A 1 476 LYS 476 476 476 LYS LYS A . n 
A 1 477 ALA 477 477 477 ALA ALA A . n 
A 1 478 ARG 478 478 478 ARG ARG A . n 
A 1 479 ILE 479 479 479 ILE ILE A . n 
A 1 480 GLY 480 480 480 GLY GLY A . n 
A 1 481 LYS 481 481 481 LYS LYS A . n 
A 1 482 GLY 482 482 482 GLY GLY A . n 
A 1 483 LEU 483 483 483 LEU LEU A . n 
A 1 484 GLU 484 484 484 GLU GLU A . n 
A 1 485 GLY 485 485 485 GLY GLY A . n 
A 1 486 PRO 486 486 486 PRO PRO A . n 
A 1 487 LEU 487 487 487 LEU LEU A . n 
A 1 488 HIS 488 488 488 HIS HIS A . n 
A 1 489 ALA 489 489 489 ALA ALA A . n 
A 1 490 LEU 490 490 490 LEU LEU A . n 
A 1 491 ASP 491 491 491 ASP ASP A . n 
A 1 492 TYR 492 492 492 TYR TYR A . n 
A 1 493 GLY 493 493 493 GLY GLY A . n 
A 1 494 TYR 494 494 494 TYR TYR A . n 
A 1 495 GLY 495 495 495 GLY GLY A . n 
A 1 496 GLU 496 496 496 GLU GLU A . n 
A 1 497 LEU 497 497 497 LEU LEU A . n 
A 1 498 ILE 498 498 498 ILE ILE A . n 
A 1 499 ASP 499 499 499 ASP ASP A . n 
A 1 500 GLY 500 500 500 GLY GLY A . n 
A 1 501 PRO 501 501 501 PRO PRO A . n 
A 1 502 LYS 502 502 502 LYS LYS A . n 
A 1 503 ILE 503 503 503 ILE ILE A . n 
A 1 504 LEU 504 504 504 LEU LEU A . n 
A 1 505 THR 505 505 505 THR THR A . n 
A 1 506 PRO 506 506 506 PRO PRO A . n 
A 1 507 ASP 507 507 507 ASP ASP A . n 
A 1 508 GLY 508 508 508 GLY GLY A . n 
A 1 509 PRO 509 509 509 PRO PRO A . n 
A 1 510 ARG 510 510 510 ARG ARG A . n 
A 1 511 CYS 511 511 511 CYS CYS A . n 
A 1 512 GLY 512 512 512 GLY GLY A . n 
A 1 513 GLU 513 513 513 GLU GLU A . n 
A 1 514 LEU 514 514 514 LEU LEU A . n 
A 1 515 ILE 515 515 515 ILE ILE A . n 
A 1 516 SER 516 516 516 SER SER A . n 
A 1 517 LEU 517 517 517 LEU LEU A . n 
A 1 518 LYS 518 518 518 LYS LYS A . n 
A 1 519 ARG 519 519 519 ARG ARG A . n 
A 1 520 ASP 520 520 520 ASP ASP A . n 
A 1 521 ILE 521 521 521 ILE ILE A . n 
A 1 522 VAL 522 522 522 VAL VAL A . n 
A 1 523 GLU 523 523 523 GLU GLU A . n 
A 1 524 ILE 524 524 524 ILE ILE A . n 
A 1 525 LYS 525 525 525 LYS LYS A . n 
A 1 526 SER 526 526 526 SER SER A . n 
A 1 527 ALA 527 527 527 ALA ALA A . n 
A 1 528 ILE 528 528 528 ILE ILE A . n 
A 1 529 LYS 529 529 529 LYS LYS A . n 
A 1 530 GLU 530 530 530 GLU GLU A . n 
A 1 531 PHE 531 531 531 PHE PHE A . n 
A 1 532 LYS 532 532 532 LYS LYS A . n 
A 1 533 ALA 533 533 533 ALA ALA A . n 
A 1 534 CYS 534 534 534 CYS CYS A . n 
A 1 535 GLN 535 535 535 GLN GLN A . n 
A 1 536 ARG 536 536 536 ARG ARG A . n 
A 1 537 GLU 537 537 537 GLU GLU A . n 
A 1 538 GLY 538 538 538 GLY GLY A . n 
A 1 539 LEU 539 539 539 LEU LEU A . n 
A 1 540 THR 540 540 540 THR THR A . n 
A 1 541 MET 541 541 541 MET MET A . n 
A 1 542 SER 542 542 542 SER SER A . n 
A 1 543 GLU 543 543 543 GLU GLU A . n 
A 1 544 GLU 544 544 544 GLU GLU A . n 
A 1 545 THR 545 545 545 THR THR A . n 
A 1 546 THR 546 546 546 THR THR A . n 
A 1 547 THR 547 547 547 THR THR A . n 
A 1 548 TRP 548 548 548 TRP TRP A . n 
A 1 549 LEU 549 549 549 LEU LEU A . n 
A 1 550 SER 550 550 550 SER SER A . n 
A 1 551 GLU 551 551 551 GLU GLU A . n 
A 1 552 VAL 552 552 552 VAL VAL A . n 
A 1 553 GLU 553 553 553 GLU GLU A . n 
A 1 554 SER 554 554 554 SER SER A . n 
A 1 555 PRO 555 555 555 PRO PRO A . n 
A 1 556 SER 556 556 556 SER SER A . n 
A 1 557 ASP 557 557 557 ASP ASP A . n 
A 1 558 SER 558 558 558 SER SER A . n 
A 1 559 PRO 559 559 559 PRO PRO A . n 
A 1 560 ARG 560 560 560 ARG ARG A . n 
A 1 561 CYS 561 561 561 CYS CYS A . n 
A 1 562 MET 562 562 562 MET MET A . n 
A 1 563 ILE 563 563 563 ILE ILE A . n 
A 1 564 GLN 564 564 564 GLN GLN A . n 
A 1 565 SER 565 565 565 SER SER A . n 
A 1 566 ARG 566 566 566 ARG ARG A . n 
A 1 567 ILE 567 567 567 ILE ILE A . n 
A 1 568 ALA 568 568 568 ALA ALA A . n 
A 1 569 ASP 569 569 569 ASP ASP A . n 
A 1 570 THR 570 570 570 THR THR A . n 
A 1 571 SER 571 571 571 SER SER A . n 
A 1 572 ARG 572 572 572 ARG ARG A . n 
A 1 573 ARG 573 573 573 ARG ARG A . n 
A 1 574 LEU 574 574 574 LEU LEU A . n 
A 1 575 ASN 575 575 575 ASN ASN A . n 
A 1 576 SER 576 576 576 SER SER A . n 
A 1 577 PHE 577 577 577 PHE PHE A . n 
A 1 578 LYS 578 578 578 LYS LYS A . n 
A 1 579 TYR 579 579 579 TYR TYR A . n 
A 1 580 GLN 580 580 580 GLN GLN A . n 
A 1 581 MET 581 581 581 MET MET A . n 
A 1 582 ASN 582 582 582 ASN ASN A . n 
A 1 583 LYS 583 583 583 LYS LYS A . n 
A 1 584 GLU 584 584 584 GLU GLU A . n 
A 1 585 GLY 585 585 585 GLY GLY A . n 
A 1 586 TYR 586 586 586 TYR TYR A . n 
A 1 587 GLN 587 587 587 GLN GLN A . n 
A 1 588 ASP 588 588 588 ASP ASP A . n 
A 1 589 LEU 589 589 589 LEU LEU A . n 
A 1 590 ALA 590 590 590 ALA ALA A . n 
A 1 591 GLU 591 591 591 GLU GLU A . n 
A 1 592 ALA 592 592 592 ALA ALA A . n 
A 1 593 LEU 593 593 593 LEU LEU A . n 
A 1 594 ARG 594 594 594 ARG ARG A . n 
A 1 595 LEU 595 595 595 LEU LEU A . n 
A 1 596 LEU 596 596 596 LEU LEU A . n 
A 1 597 ASP 597 597 597 ASP ASP A . n 
A 1 598 ALA 598 598 598 ALA ALA A . n 
A 1 599 MET 599 599 599 MET MET A . n 
A 1 600 ASP 600 600 600 ASP ASP A . n 
A 1 601 SER 601 601 601 SER SER A . n 
A 1 602 TYR 602 602 602 TYR TYR A . n 
A 1 603 ASN 603 603 603 ASN ASN A . n 
A 1 604 SER 604 604 604 SER SER A . n 
A 1 605 LEU 605 605 605 LEU LEU A . n 
A 1 606 LEU 606 606 606 LEU LEU A . n 
A 1 607 GLU 607 607 607 GLU GLU A . n 
A 1 608 SER 608 608 608 SER SER A . n 
A 1 609 TYR 609 609 609 TYR TYR A . n 
A 1 610 GLN 610 610 610 GLN GLN A . n 
A 1 611 ARG 611 611 611 ARG ARG A . n 
A 1 612 MET 612 612 612 MET MET A . n 
A 1 613 HIS 613 613 613 HIS HIS A . n 
A 1 614 LEU 614 614 614 LEU LEU A . n 
A 1 615 SER 615 615 615 SER SER A . n 
A 1 616 PRO 616 616 ?   ?   ?   A . n 
A 1 617 GLY 617 617 ?   ?   ?   A . n 
A 1 618 GLU 618 618 ?   ?   ?   A . n 
A 1 619 GLN 619 619 ?   ?   ?   A . n 
A 1 620 SER 620 620 ?   ?   ?   A . n 
A 1 621 PRO 621 621 ?   ?   ?   A . n 
A 1 622 LYS 622 622 ?   ?   ?   A . n 
A 1 623 GLU 623 623 ?   ?   ?   A . n 
A 1 624 ALA 624 624 ?   ?   ?   A . n 
A 1 625 LYS 625 625 ?   ?   ?   A . n 
A 1 626 PHE 626 626 ?   ?   ?   A . n 
A 1 627 ASP 627 627 627 ASP ASP A . n 
A 1 628 THR 628 628 628 THR THR A . n 
A 1 629 LYS 629 629 629 LYS LYS A . n 
A 1 630 ARG 630 630 630 ARG ARG A . n 
A 1 631 ALA 631 631 631 ALA ALA A . n 
A 1 632 SER 632 632 632 SER SER A . n 
A 1 633 PHE 633 633 633 PHE PHE A . n 
A 1 634 ARG 634 634 634 ARG ARG A . n 
A 1 635 ASP 635 635 635 ASP ASP A . n 
A 1 636 LEU 636 636 636 LEU LEU A . n 
A 1 637 LEU 637 637 637 LEU LEU A . n 
A 1 638 ARG 638 638 638 ARG ARG A . n 
A 1 639 ARG 639 639 639 ARG ARG A . n 
A 1 640 ARG 640 640 640 ARG ARG A . n 
A 1 641 VAL 641 641 641 VAL VAL A . n 
A 1 642 ALA 642 642 642 ALA ALA A . n 
A 1 643 HIS 643 643 643 HIS HIS A . n 
A 1 644 THR 644 644 644 THR THR A . n 
A 1 645 ILE 645 645 645 ILE ILE A . n 
A 1 646 VAL 646 646 646 VAL VAL A . n 
A 1 647 GLU 647 647 647 GLU GLU A . n 
A 1 648 TYR 648 648 648 TYR TYR A . n 
A 1 649 PHE 649 649 649 PHE PHE A . n 
A 1 650 ASP 650 650 650 ASP ASP A . n 
A 1 651 ASP 651 651 651 ASP ASP A . n 
A 1 652 CYS 652 652 652 CYS CYS A . n 
A 1 653 ASP 653 653 653 ASP ASP A . n 
A 1 654 ILE 654 654 654 ILE ILE A . n 
A 1 655 VAL 655 655 655 VAL VAL A . n 
A 1 656 PHE 656 656 656 PHE PHE A . n 
A 1 657 PHE 657 657 657 PHE PHE A . n 
A 1 658 GLU 658 658 658 GLU GLU A . n 
A 1 659 ASP 659 659 659 ASP ASP A . n 
A 1 660 LEU 660 660 660 LEU LEU A . n 
A 1 661 ASP 661 661 661 ASP ASP A . n 
A 1 662 GLY 662 662 ?   ?   ?   A . n 
A 1 663 PRO 663 663 ?   ?   ?   A . n 
A 1 664 SER 664 664 ?   ?   ?   A . n 
A 1 665 ASP 665 665 ?   ?   ?   A . n 
A 1 666 SER 666 666 ?   ?   ?   A . n 
A 1 667 ASP 667 667 ?   ?   ?   A . n 
A 1 668 SER 668 668 ?   ?   ?   A . n 
A 1 669 ARG 669 669 ?   ?   ?   A . n 
A 1 670 ASN 670 670 ?   ?   ?   A . n 
A 1 671 ASN 671 671 671 ASN ASN A . n 
A 1 672 ALA 672 672 672 ALA ALA A . n 
A 1 673 LEU 673 673 673 LEU LEU A . n 
A 1 674 VAL 674 674 674 VAL VAL A . n 
A 1 675 LYS 675 675 675 LYS LYS A . n 
A 1 676 LEU 676 676 676 LEU LEU A . n 
A 1 677 LEU 677 677 677 LEU LEU A . n 
A 1 678 SER 678 678 678 SER SER A . n 
A 1 679 PRO 679 679 679 PRO PRO A . n 
A 1 680 ARG 680 680 680 ARG ARG A . n 
A 1 681 THR 681 681 681 THR THR A . n 
A 1 682 LEU 682 682 682 LEU LEU A . n 
A 1 683 LEU 683 683 683 LEU LEU A . n 
A 1 684 LEU 684 684 684 LEU LEU A . n 
A 1 685 TYR 685 685 685 TYR TYR A . n 
A 1 686 ILE 686 686 686 ILE ILE A . n 
A 1 687 ARG 687 687 687 ARG ARG A . n 
A 1 688 GLN 688 688 688 GLN GLN A . n 
A 1 689 ALA 689 689 689 ALA ALA A . n 
A 1 690 LEU 690 690 690 LEU LEU A . n 
A 1 691 GLU 691 691 691 GLU GLU A . n 
A 1 692 LYS 692 692 692 LYS LYS A . n 
A 1 693 ARG 693 693 693 ARG ARG A . n 
A 1 694 GLY 694 694 694 GLY GLY A . n 
A 1 695 ILE 695 695 695 ILE ILE A . n 
A 1 696 GLY 696 696 696 GLY GLY A . n 
A 1 697 MET 697 697 697 MET MET A . n 
A 1 698 VAL 698 698 698 VAL VAL A . n 
A 1 699 GLU 699 699 699 GLU GLU A . n 
A 1 700 VAL 700 700 700 VAL VAL A . n 
A 1 701 ALA 701 701 701 ALA ALA A . n 
A 1 702 LYS 702 702 702 LYS LYS A . n 
A 1 703 ASP 703 703 703 ASP ASP A . n 
A 1 704 GLY 704 704 704 GLY GLY A . n 
A 1 705 THR 705 705 705 THR THR A . n 
A 1 706 SER 706 706 706 SER SER A . n 
A 1 707 GLN 707 707 707 GLN GLN A . n 
A 1 708 ASN 708 708 708 ASN ASN A . n 
A 1 709 ASN 709 709 709 ASN ASN A . n 
A 1 710 PRO 710 710 710 PRO PRO A . n 
A 1 711 ILE 711 711 711 ILE ILE A . n 
A 1 712 SER 712 712 712 SER SER A . n 
A 1 713 GLY 713 713 713 GLY GLY A . n 
A 1 714 HIS 714 714 714 HIS HIS A . n 
A 1 715 VAL 715 715 715 VAL VAL A . n 
A 1 716 GLY 716 716 716 GLY GLY A . n 
A 1 717 TRP 717 717 717 TRP TRP A . n 
A 1 718 ARG 718 718 718 ARG ARG A . n 
A 1 719 ASN 719 719 719 ASN ASN A . n 
A 1 720 LYS 720 720 720 LYS LYS A . n 
A 1 721 GLN 721 721 721 GLN GLN A . n 
A 1 722 ASN 722 722 722 ASN ASN A . n 
A 1 723 LYS 723 723 723 LYS LYS A . n 
A 1 724 SER 724 724 724 SER SER A . n 
A 1 725 GLU 725 725 725 GLU GLU A . n 
A 1 726 ILE 726 726 726 ILE ILE A . n 
A 1 727 TYR 727 727 727 TYR TYR A . n 
A 1 728 PHE 728 728 728 PHE PHE A . n 
A 1 729 TYR 729 729 729 TYR TYR A . n 
A 1 730 GLU 730 730 730 GLU GLU A . n 
A 1 731 ASP 731 731 731 ASP ASP A . n 
A 1 732 LYS 732 732 732 LYS LYS A . n 
A 1 733 GLU 733 733 733 GLU GLU A . n 
A 1 734 LEU 734 734 734 LEU LEU A . n 
A 1 735 LEU 735 735 735 LEU LEU A . n 
A 1 736 VAL 736 736 736 VAL VAL A . n 
A 1 737 MET 737 737 737 MET MET A . n 
A 1 738 ASP 738 738 738 ASP ASP A . n 
A 1 739 ALA 739 739 739 ALA ALA A . n 
A 1 740 ASP 740 740 740 ASP ASP A . n 
A 1 741 GLU 741 741 741 GLU GLU A . n 
A 1 742 VAL 742 742 742 VAL VAL A . n 
A 1 743 GLY 743 743 743 GLY GLY A . n 
A 1 744 ALA 744 744 744 ALA ALA A . n 
A 1 745 MET 745 745 745 MET MET A . n 
A 1 746 ASN 746 746 746 ASN ASN A . n 
A 1 747 ILE 747 747 747 ILE ILE A . n 
A 1 748 LEU 748 748 748 LEU LEU A . n 
A 1 749 CYS 749 749 749 CYS CYS A . n 
A 1 750 ARG 750 750 750 ARG ARG A . n 
A 1 751 GLY 751 751 751 GLY GLY A . n 
A 1 752 LEU 752 752 752 LEU LEU A . n 
A 1 753 ASN 753 753 753 ASN ASN A . n 
A 1 754 HIS 754 754 754 HIS HIS A . n 
A 1 755 SER 755 755 755 SER SER A . n 
A 1 756 VAL 756 756 756 VAL VAL A . n 
A 1 757 CYS 757 757 757 CYS CYS A . n 
A 1 758 PRO 758 758 758 PRO PRO A . n 
A 1 759 TYR 759 759 759 TYR TYR A . n 
A 1 760 SER 760 760 760 SER SER A . n 
A 1 761 PHE 761 761 761 PHE PHE A . n 
A 1 762 VAL 762 762 762 VAL VAL A . n 
A 1 763 THR 763 763 763 THR THR A . n 
A 1 764 LYS 764 764 ?   ?   ?   A . n 
A 1 765 ALA 765 765 ?   ?   ?   A . n 
A 1 766 PRO 766 766 ?   ?   ?   A . n 
A 1 767 GLU 767 767 ?   ?   ?   A . n 
A 1 768 LYS 768 768 ?   ?   ?   A . n 
A 1 769 LYS 769 769 ?   ?   ?   A . n 
A 1 770 ASN 770 770 ?   ?   ?   A . n 
A 1 771 ASP 771 771 ?   ?   ?   A . n 
A 1 772 GLU 772 772 ?   ?   ?   A . n 
A 1 773 LYS 773 773 ?   ?   ?   A . n 
A 1 774 LYS 774 774 ?   ?   ?   A . n 
A 1 775 GLU 775 775 ?   ?   ?   A . n 
A 1 776 GLY 776 776 ?   ?   ?   A . n 
A 1 777 ASP 777 777 ?   ?   ?   A . n 
A 1 778 TYR 778 778 778 TYR TYR A . n 
A 1 779 GLY 779 779 779 GLY GLY A . n 
A 1 780 LYS 780 780 780 LYS LYS A . n 
A 1 781 ARG 781 781 781 ARG ARG A . n 
A 1 782 VAL 782 782 782 VAL VAL A . n 
A 1 783 LYS 783 783 783 LYS LYS A . n 
A 1 784 ARG 784 784 784 ARG ARG A . n 
A 1 785 PHE 785 785 785 PHE PHE A . n 
A 1 786 LEU 786 786 786 LEU LEU A . n 
A 1 787 LYS 787 787 787 LYS LYS A . n 
A 1 788 ASP 788 788 788 ASP ASP A . n 
A 1 789 ARG 789 789 789 ARG ARG A . n 
A 1 790 TYR 790 790 790 TYR TYR A . n 
A 1 791 GLY 791 791 791 GLY GLY A . n 
A 1 792 SER 792 792 792 SER SER A . n 
A 1 793 SER 793 793 793 SER SER A . n 
A 1 794 ASN 794 794 794 ASN ASN A . n 
A 1 795 VAL 795 795 795 VAL VAL A . n 
A 1 796 ARG 796 796 796 ARG ARG A . n 
A 1 797 PHE 797 797 797 PHE PHE A . n 
A 1 798 LEU 798 798 798 LEU LEU A . n 
A 1 799 VAL 799 799 799 VAL VAL A . n 
A 1 800 ALA 800 800 800 ALA ALA A . n 
A 1 801 SER 801 801 801 SER SER A . n 
A 1 802 MET 802 802 802 MET MET A . n 
A 1 803 GLY 803 803 803 GLY GLY A . n 
A 1 804 PHE 804 804 804 PHE PHE A . n 
A 1 805 VAL 805 805 805 VAL VAL A . n 
A 1 806 THR 806 806 806 THR THR A . n 
A 1 807 VAL 807 807 807 VAL VAL A . n 
A 1 808 THR 808 808 808 THR THR A . n 
A 1 809 THR 809 809 809 THR THR A . n 
A 1 810 LYS 810 810 ?   ?   ?   A . n 
A 1 811 ARG 811 811 ?   ?   ?   A . n 
A 1 812 PRO 812 812 ?   ?   ?   A . n 
A 1 813 LYS 813 813 ?   ?   ?   A . n 
A 1 814 ASP 814 814 ?   ?   ?   A . n 
A 1 815 ALA 815 815 815 ALA ALA A . n 
A 1 816 LEU 816 816 816 LEU LEU A . n 
A 1 817 VAL 817 817 817 VAL VAL A . n 
A 1 818 GLY 818 818 818 GLY GLY A . n 
A 1 819 LYS 819 819 819 LYS LYS A . n 
A 1 820 ARG 820 820 820 ARG ARG A . n 
A 1 821 LEU 821 821 821 LEU LEU A . n 
A 1 822 TYR 822 822 822 TYR TYR A . n 
A 1 823 TYR 823 823 823 TYR TYR A . n 
A 1 824 HIS 824 824 824 HIS HIS A . n 
A 1 825 GLY 825 825 825 GLY GLY A . n 
A 1 826 GLY 826 826 826 GLY GLY A . n 
A 1 827 GLU 827 827 827 GLU GLU A . n 
A 1 828 LEU 828 828 828 LEU LEU A . n 
A 1 829 VAL 829 829 829 VAL VAL A . n 
A 1 830 THR 830 830 830 THR THR A . n 
A 1 831 HIS 831 831 831 HIS HIS A . n 
A 1 832 ASP 832 832 832 ASP ASP A . n 
A 1 833 LEU 833 833 833 LEU LEU A . n 
A 1 834 HIS 834 834 834 HIS HIS A . n 
A 1 835 ASN 835 835 835 ASN ASN A . n 
A 1 836 ARG 836 836 836 ARG ARG A . n 
A 1 837 MET 837 837 837 MET MET A . n 
A 1 838 LYS 838 838 838 LYS LYS A . n 
A 1 839 ASP 839 839 839 ASP ASP A . n 
A 1 840 GLU 840 840 840 GLU GLU A . n 
A 1 841 ILE 841 841 841 ILE ILE A . n 
A 1 842 LYS 842 842 842 LYS LYS A . n 
A 1 843 TYR 843 843 843 TYR TYR A . n 
A 1 844 LEU 844 844 844 LEU LEU A . n 
A 1 845 VAL 845 845 845 VAL VAL A . n 
A 1 846 GLU 846 846 846 GLU GLU A . n 
A 1 847 LYS 847 847 847 LYS LYS A . n 
A 1 848 GLU 848 848 848 GLU GLU A . n 
A 1 849 VAL 849 849 849 VAL VAL A . n 
A 1 850 LEU 850 850 850 LEU LEU A . n 
A 1 851 ALA 851 851 851 ALA ALA A . n 
A 1 852 ARG 852 852 852 ARG ARG A . n 
A 1 853 ARG 853 853 853 ARG ARG A . n 
A 1 854 VAL 854 854 854 VAL VAL A . n 
A 1 855 SER 855 855 855 SER SER A . n 
A 1 856 LEU 856 856 856 LEU LEU A . n 
A 1 857 SER 857 857 857 SER SER A . n 
A 1 858 ASP 858 858 858 ASP ASP A . n 
A 1 859 SER 859 859 859 SER SER A . n 
A 1 860 THR 860 860 860 THR THR A . n 
A 1 861 ILE 861 861 861 ILE ILE A . n 
A 1 862 LYS 862 862 862 LYS LYS A . n 
A 1 863 SER 863 863 863 SER SER A . n 
A 1 864 TYR 864 864 864 TYR TYR A . n 
A 1 865 LYS 865 865 865 LYS LYS A . n 
A 1 866 SER 866 866 866 SER SER A . n 
A 1 867 PHE 867 867 867 PHE PHE A . n 
A 1 868 ALA 868 868 868 ALA ALA A . n 
A 1 869 HIS 869 869 869 HIS HIS A . n 
A 1 870 VAL 870 870 870 VAL VAL A . n 
B 2 1   G   1   -35 -35 G   G   B . n 
B 2 2   U   2   -34 -34 U   U   B . n 
B 2 3   G   3   -33 -33 G   G   B . n 
B 2 4   C   4   -32 -32 C   C   B . n 
B 2 5   U   5   -31 -31 U   U   B . n 
B 2 6   G   6   -30 -30 G   G   B . n 
B 2 7   G   7   -29 -29 G   G   B . n 
B 2 8   C   8   -28 -28 C   C   B . n 
B 2 9   C   9   -27 -27 C   C   B . n 
B 2 10  G   10  -26 -26 G   G   B . n 
B 2 11  C   11  -25 -25 C   C   B . n 
B 2 12  U   12  -24 -24 U   U   B . n 
B 2 13  C   13  -23 -23 C   C   B . n 
B 2 14  U   14  -22 -22 U   U   B . n 
B 2 15  C   15  -21 -21 C   C   B . n 
B 2 16  G   16  -20 -20 G   G   B . n 
B 2 17  C   17  -19 -19 C   C   B . n 
B 2 18  U   18  -18 -18 U   U   B . n 
B 2 19  A   19  -17 -17 A   A   B . n 
B 2 20  G   20  -16 -16 G   G   B . n 
B 2 21  A   21  -15 -15 A   A   B . n 
B 2 22  G   22  -14 -14 G   G   B . n 
B 2 23  G   23  -13 -13 G   G   B . n 
B 2 24  G   24  -12 -12 G   G   B . n 
B 2 25  A   25  -11 -11 A   A   B . n 
B 2 26  G   26  -10 -10 G   G   B . n 
B 2 27  G   27  -9  -9  G   G   B . n 
B 2 28  U   28  -8  -8  U   U   B . n 
B 2 29  C   29  -7  -7  C   C   B . n 
B 2 30  A   30  -6  -6  A   A   B . n 
B 2 31  G   31  -5  -5  G   G   B . n 
B 2 32  A   32  -4  -4  A   A   B . n 
B 2 33  G   33  -3  -3  G   G   B . n 
B 2 34  C   34  -2  -2  C   C   B . n 
B 2 35  A   35  -1  -1  A   A   B . n 
B 2 36  C   36  0   0   C   C   B . n 
B 2 37  A   37  1   1   A   A   B . n 
B 2 38  U   38  2   2   U   U   B . n 
B 2 39  A   39  3   3   A   A   B . n 
B 2 40  A   40  4   4   A   A   B . n 
B 2 41  U   41  5   5   U   U   B . n 
B 2 42  A   42  6   ?   ?   ?   B . n 
B 2 43  U   43  7   ?   ?   ?   B . n 
B 2 44  C   44  8   ?   ?   ?   B . n 
B 2 45  A   45  9   ?   ?   ?   B . n 
B 2 46  A   46  10  ?   ?   ?   B . n 
B 2 47  U   47  11  ?   ?   ?   B . n 
B 2 48  G   48  12  ?   ?   ?   B . n 
B 2 49  G   49  13  ?   ?   ?   B . n 
B 2 50  A   50  14  ?   ?   ?   B . n 
B 2 51  A   51  15  ?   ?   ?   B . n 
B 2 52  U   52  16  ?   ?   ?   B . n 
B 2 53  A   53  17  ?   ?   ?   B . n 
B 2 54  U   54  18  ?   ?   ?   B . n 
B 2 55  A   55  19  ?   ?   ?   B . n 
B 2 56  G   56  20  ?   ?   ?   B . n 
B 2 57  C   57  21  ?   ?   ?   B . n 
B 2 58  A   58  22  ?   ?   ?   B . n 
B 2 59  A   59  23  ?   ?   ?   B . n 
B 2 60  G   60  24  ?   ?   ?   B . n 
B 2 61  C   61  25  ?   ?   ?   B . n 
B 2 62  U   62  26  ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        MG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   MG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         C 
_pdbx_nonpoly_scheme.entity_id       3 
_pdbx_nonpoly_scheme.mon_id          MG 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     901 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      MG 
_pdbx_nonpoly_scheme.auth_mon_id     MG 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Y9L 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Y9L 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Y9L 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8Y9L 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004  ? 7262 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.536  ? 9983 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 12.224 ? 1331 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040  ? 1118 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 1118 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8Y9L 
_struct.title                        'Cas12h1-crRNA binary complex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Y9L 
_struct_keywords.text            'Cas effector, IMMUNE SYSTEM, IMMUNE SYSTEM-RNA complex' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM/RNA' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8Y9L 8Y9L ? 1 ? 1 
2 PDB 8Y9L 8Y9L ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8Y9L A 1 ? 870 ? 8Y9L 1   ? 870 ? 1   870 
2 2 8Y9L B 1 ? 62  ? 8Y9L -35 ? 26  ? -35 26  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 20  ? TRP A 42  ? SER A 20  TRP A 42  1 ? 23 
HELX_P HELX_P2  AA2 ALA A 49  ? ASP A 53  ? ALA A 49  ASP A 53  5 ? 5  
HELX_P HELX_P3  AA3 SER A 59  ? GLY A 72  ? SER A 59  GLY A 72  1 ? 14 
HELX_P HELX_P4  AA4 ALA A 74  ? GLY A 88  ? ALA A 74  GLY A 88  1 ? 15 
HELX_P HELX_P5  AA5 GLY A 89  ? SER A 94  ? GLY A 89  SER A 94  1 ? 6  
HELX_P HELX_P6  AA6 LEU A 175 ? GLY A 184 ? LEU A 175 GLY A 184 1 ? 10 
HELX_P HELX_P7  AA7 ASP A 192 ? ASN A 230 ? ASP A 192 ASN A 230 1 ? 39 
HELX_P HELX_P8  AA8 THR A 233 ? LYS A 249 ? THR A 233 LYS A 249 1 ? 17 
HELX_P HELX_P9  AA9 GLY A 254 ? LEU A 266 ? GLY A 254 LEU A 266 1 ? 13 
HELX_P HELX_P10 AB1 GLN A 276 ? LEU A 282 ? GLN A 276 LEU A 282 1 ? 7  
HELX_P HELX_P11 AB2 GLN A 284 ? LYS A 286 ? GLN A 284 LYS A 286 5 ? 3  
HELX_P HELX_P12 AB3 PHE A 287 ? THR A 292 ? PHE A 287 THR A 292 1 ? 6  
HELX_P HELX_P13 AB4 LYS A 294 ? ARG A 314 ? LYS A 294 ARG A 314 1 ? 21 
HELX_P HELX_P14 AB5 ILE A 432 ? PHE A 441 ? ILE A 432 PHE A 441 1 ? 10 
HELX_P HELX_P15 AB6 ASP A 448 ? LEU A 455 ? ASP A 448 LEU A 455 1 ? 8  
HELX_P HELX_P16 AB7 GLY A 508 ? CYS A 511 ? GLY A 508 CYS A 511 5 ? 4  
HELX_P HELX_P17 AB8 GLY A 512 ? GLU A 537 ? GLY A 512 GLU A 537 1 ? 26 
HELX_P HELX_P18 AB9 SER A 542 ? SER A 550 ? SER A 542 SER A 550 1 ? 9  
HELX_P HELX_P19 AC1 ARG A 560 ? GLU A 584 ? ARG A 560 GLU A 584 1 ? 25 
HELX_P HELX_P20 AC2 GLU A 591 ? GLN A 610 ? GLU A 591 GLN A 610 1 ? 20 
HELX_P HELX_P21 AC3 SER A 632 ? PHE A 649 ? SER A 632 PHE A 649 1 ? 18 
HELX_P HELX_P22 AC4 ARG A 680 ? LYS A 692 ? ARG A 680 LYS A 692 1 ? 13 
HELX_P HELX_P23 AC5 ALA A 739 ? ASN A 753 ? ALA A 739 ASN A 753 1 ? 15 
HELX_P HELX_P24 AC6 GLY A 779 ? TYR A 790 ? GLY A 779 TYR A 790 1 ? 12 
HELX_P HELX_P25 AC7 HIS A 831 ? LYS A 847 ? HIS A 831 LYS A 847 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A ASP 465 OD1 ? ? ? 1_555 C MG .  MG ? ? A ASP 465 A MG 901 1_555 ? ? ? ? ? ? ?             2.420 ? ? 
metalc2  metalc ? ? A ASP 465 OD2 ? ? ? 1_555 C MG .  MG ? ? A ASP 465 A MG 901 1_555 ? ? ? ? ? ? ?             2.114 ? ? 
hydrog1  hydrog ? ? B G   1   N1  ? ? ? 1_555 B C  36 N3 ? ? B G   -35 B C  0   1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog2  hydrog ? ? B G   1   N2  ? ? ? 1_555 B C  36 O2 ? ? B G   -35 B C  0   1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog3  hydrog ? ? B G   1   O6  ? ? ? 1_555 B C  36 N4 ? ? B G   -35 B C  0   1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog4  hydrog ? ? B U   2   N3  ? ? ? 1_555 B A  35 N1 ? ? B U   -34 B A  -1  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog5  hydrog ? ? B U   2   O4  ? ? ? 1_555 B A  35 N6 ? ? B U   -34 B A  -1  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog6  hydrog ? ? B G   3   N2  ? ? ? 1_555 B C  34 O2 ? ? B G   -33 B C  -2  1_555 ? ? ? ? ? ? 'G-C PAIR'    ?     ? ? 
hydrog7  hydrog ? ? B C   4   N3  ? ? ? 1_555 B G  33 N1 ? ? B C   -32 B G  -3  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog8  hydrog ? ? B C   4   N4  ? ? ? 1_555 B G  33 O6 ? ? B C   -32 B G  -3  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog9  hydrog ? ? B C   4   O2  ? ? ? 1_555 B G  33 N2 ? ? B C   -32 B G  -3  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog10 hydrog ? ? B U   5   N3  ? ? ? 1_555 B A  30 N1 ? ? B U   -31 B A  -6  1_555 ? ? ? ? ? ? 'U-A PAIR'    ?     ? ? 
hydrog11 hydrog ? ? B G   6   O6  ? ? ? 1_555 B C  29 N4 ? ? B G   -30 B C  -7  1_555 ? ? ? ? ? ? 'G-C PAIR'    ?     ? ? 
hydrog12 hydrog ? ? B G   7   N1  ? ? ? 1_555 B U  28 O2 ? ? B G   -29 B U  -8  1_555 ? ? ? ? ? ? TYPE_28_PAIR  ?     ? ? 
hydrog13 hydrog ? ? B G   7   O6  ? ? ? 1_555 B U  28 N3 ? ? B G   -29 B U  -8  1_555 ? ? ? ? ? ? TYPE_28_PAIR  ?     ? ? 
hydrog14 hydrog ? ? B C   8   N3  ? ? ? 1_555 B G  27 N1 ? ? B C   -28 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog15 hydrog ? ? B C   8   N4  ? ? ? 1_555 B G  27 O6 ? ? B C   -28 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog16 hydrog ? ? B C   8   O2  ? ? ? 1_555 B G  27 N2 ? ? B C   -28 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog17 hydrog ? ? B C   9   N3  ? ? ? 1_555 B G  26 N1 ? ? B C   -27 B G  -10 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog18 hydrog ? ? B C   9   N4  ? ? ? 1_555 B G  26 O6 ? ? B C   -27 B G  -10 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog19 hydrog ? ? B C   9   O2  ? ? ? 1_555 B G  26 N2 ? ? B C   -27 B G  -10 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog20 hydrog ? ? B G   10  O6  ? ? ? 1_555 B A  25 N6 ? ? B G   -26 B A  -11 1_555 ? ? ? ? ? ? 'G-A MISPAIR' ?     ? ? 
hydrog21 hydrog ? ? B C   11  N3  ? ? ? 1_555 B G  24 N1 ? ? B C   -25 B G  -12 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog22 hydrog ? ? B C   11  N4  ? ? ? 1_555 B G  24 O6 ? ? B C   -25 B G  -12 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog23 hydrog ? ? B C   11  O2  ? ? ? 1_555 B G  24 N2 ? ? B C   -25 B G  -12 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog24 hydrog ? ? B U   12  N3  ? ? ? 1_555 B G  23 O6 ? ? B U   -24 B G  -13 1_555 ? ? ? ? ? ? TYPE_28_PAIR  ?     ? ? 
hydrog25 hydrog ? ? B U   12  O2  ? ? ? 1_555 B G  23 N1 ? ? B U   -24 B G  -13 1_555 ? ? ? ? ? ? TYPE_28_PAIR  ?     ? ? 
hydrog26 hydrog ? ? B C   13  N3  ? ? ? 1_555 B G  22 N1 ? ? B C   -23 B G  -14 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog27 hydrog ? ? B C   13  N4  ? ? ? 1_555 B G  22 O6 ? ? B C   -23 B G  -14 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog28 hydrog ? ? B C   13  O2  ? ? ? 1_555 B G  22 N2 ? ? B C   -23 B G  -14 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog29 hydrog ? ? B U   14  N3  ? ? ? 1_555 B A  21 N1 ? ? B U   -22 B A  -15 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog30 hydrog ? ? B U   14  O4  ? ? ? 1_555 B A  21 N6 ? ? B U   -22 B A  -15 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog31 hydrog ? ? B C   15  N3  ? ? ? 1_555 B G  20 N1 ? ? B C   -21 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog32 hydrog ? ? B C   15  N4  ? ? ? 1_555 B G  20 O6 ? ? B C   -21 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
hydrog33 hydrog ? ? B C   15  O2  ? ? ? 1_555 B G  20 N2 ? ? B C   -21 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK  ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
metalc ? ? 
hydrog ? ? 
# 
_pdbx_struct_conn_angle.id                    1 
_pdbx_struct_conn_angle.ptnr1_label_atom_id   OD1 
_pdbx_struct_conn_angle.ptnr1_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr1_label_asym_id   A 
_pdbx_struct_conn_angle.ptnr1_label_comp_id   ASP 
_pdbx_struct_conn_angle.ptnr1_label_seq_id    465 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id    A 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id    ASP 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id     465 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr1_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr2_label_atom_id   MG 
_pdbx_struct_conn_angle.ptnr2_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr2_label_asym_id   C 
_pdbx_struct_conn_angle.ptnr2_label_comp_id   MG 
_pdbx_struct_conn_angle.ptnr2_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id    A 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id    MG 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id     901 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr2_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr3_label_atom_id   OD2 
_pdbx_struct_conn_angle.ptnr3_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr3_label_asym_id   A 
_pdbx_struct_conn_angle.ptnr3_label_comp_id   ASP 
_pdbx_struct_conn_angle.ptnr3_label_seq_id    465 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id    A 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id    ASP 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id     465 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr3_symmetry        1_555 
_pdbx_struct_conn_angle.value                 57.3 
_pdbx_struct_conn_angle.value_esd             ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 7 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 5   ? ARG A 8   ? GLU A 5   ARG A 8   
AA1 2 TYR A 426 ? SER A 429 ? TYR A 426 SER A 429 
AA1 3 ILE A 403 ? LEU A 407 ? ILE A 403 LEU A 407 
AA1 4 ARG A 377 ? PHE A 382 ? ARG A 377 PHE A 382 
AA1 5 LYS A 373 ? HIS A 374 ? LYS A 373 HIS A 374 
AA2 1 ILE A 329 ? GLY A 332 ? ILE A 329 GLY A 332 
AA2 2 GLU A 409 ? LYS A 414 ? GLU A 409 LYS A 414 
AA2 3 PHE A 420 ? GLY A 423 ? PHE A 420 GLY A 423 
AA2 4 LEU A 11  ? TYR A 17  ? LEU A 11  TYR A 17  
AA2 5 GLY A 356 ? CYS A 360 ? GLY A 356 CYS A 360 
AA2 6 VAL A 348 ? LEU A 352 ? VAL A 348 LEU A 352 
AA2 7 LEU A 341 ? VAL A 343 ? LEU A 341 VAL A 343 
AA3 1 LEU A 487 ? ALA A 489 ? LEU A 487 ALA A 489 
AA3 2 GLY A 493 ? LEU A 497 ? GLY A 493 LEU A 497 
AA3 3 VAL A 475 ? GLY A 480 ? VAL A 475 GLY A 480 
AA3 4 MET A 459 ? ALA A 463 ? MET A 459 ALA A 463 
AA3 5 ILE A 654 ? GLU A 658 ? ILE A 654 GLU A 658 
AA3 6 GLY A 696 ? VAL A 700 ? GLY A 696 VAL A 700 
AA4 1 TRP A 717 ? ARG A 718 ? TRP A 717 ARG A 718 
AA4 2 GLU A 725 ? GLU A 730 ? GLU A 725 GLU A 730 
AA4 3 GLU A 733 ? ASP A 738 ? GLU A 733 ASP A 738 
AA4 4 ARG A 852 ? ARG A 853 ? ARG A 852 ARG A 853 
AA5 1 SER A 760 ? PHE A 761 ? SER A 760 PHE A 761 
AA5 2 LEU A 821 ? HIS A 824 ? LEU A 821 HIS A 824 
AA5 3 GLU A 827 ? THR A 830 ? GLU A 827 THR A 830 
AA6 1 ARG A 796 ? ALA A 800 ? ARG A 796 ALA A 800 
AA6 2 PHE A 804 ? THR A 808 ? PHE A 804 THR A 808 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 6   ? N ILE A 6   O LEU A 428 ? O LEU A 428 
AA1 2 3 O ALA A 427 ? O ALA A 427 N ALA A 406 ? N ALA A 406 
AA1 3 4 O LEU A 407 ? O LEU A 407 N TYR A 378 ? N TYR A 378 
AA1 4 5 O ARG A 377 ? O ARG A 377 N HIS A 374 ? N HIS A 374 
AA2 1 2 N ILE A 329 ? N ILE A 329 O ILE A 412 ? O ILE A 412 
AA2 2 3 N THR A 411 ? N THR A 411 O GLY A 423 ? O GLY A 423 
AA2 3 4 O LEU A 422 ? O LEU A 422 N LEU A 12  ? N LEU A 12  
AA2 4 5 N LYS A 15  ? N LYS A 15  O PHE A 359 ? O PHE A 359 
AA2 5 6 O CYS A 360 ? O CYS A 360 N VAL A 348 ? N VAL A 348 
AA2 6 7 O VAL A 349 ? O VAL A 349 N GLU A 342 ? N GLU A 342 
AA3 1 2 N ALA A 489 ? N ALA A 489 O GLY A 493 ? O GLY A 493 
AA3 2 3 O GLU A 496 ? O GLU A 496 N ARG A 478 ? N ARG A 478 
AA3 3 4 O ALA A 477 ? O ALA A 477 N VAL A 461 ? N VAL A 461 
AA3 4 5 N GLY A 462 ? N GLY A 462 O PHE A 656 ? O PHE A 656 
AA3 5 6 N PHE A 657 ? N PHE A 657 O VAL A 698 ? O VAL A 698 
AA4 1 2 N TRP A 717 ? N TRP A 717 O TYR A 727 ? O TYR A 727 
AA4 2 3 N PHE A 728 ? N PHE A 728 O LEU A 735 ? O LEU A 735 
AA4 3 4 N VAL A 736 ? N VAL A 736 O ARG A 852 ? O ARG A 852 
AA5 1 2 N PHE A 761 ? N PHE A 761 O LEU A 821 ? O LEU A 821 
AA5 2 3 N TYR A 822 ? N TYR A 822 O VAL A 829 ? O VAL A 829 
AA6 1 2 N LEU A 798 ? N LEU A 798 O THR A 806 ? O THR A 806 
# 
_pdbx_entry_details.entry_id                   8Y9L 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 "O2'" B C   0  ? ? OP1 B U   2   ? ? 1.95 
2 1 ND1   A HIS 4  ? ? O   A HIS 430 ? ? 2.17 
3 1 OD2   A ASP 31 ? ? OH  A TYR 195 ? ? 2.18 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 "O3'" B C 0 ? ? P   B A 1 ? ? 1.515 1.607 -0.092 0.012 Y 
2 1 "O3'" B A 1 ? ? P   B U 2 ? ? 1.529 1.607 -0.078 0.012 Y 
3 1 P     B U 2 ? ? OP1 B U 2 ? ? 1.380 1.485 -0.105 0.017 N 
4 1 P     B U 2 ? ? OP2 B U 2 ? ? 1.376 1.485 -0.109 0.017 N 
5 1 "O3'" B U 2 ? ? P   B A 3 ? ? 1.523 1.607 -0.084 0.012 Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB    A PRO 7 ? ? CA    A PRO 7 ? ? C     A PRO 7 ? ? 97.82  111.70 -13.88 2.10 N 
2 1 "O5'" B A   1 ? ? P     B A   1 ? ? OP1   B A   1 ? ? 86.36  105.70 -19.34 0.90 N 
3 1 "O5'" B A   1 ? ? P     B A   1 ? ? OP2   B A   1 ? ? 119.56 110.70 8.86   1.20 N 
4 1 "O4'" B A   1 ? ? "C1'" B A   1 ? ? "C2'" B A   1 ? ? 97.91  105.80 -7.89  1.00 N 
5 1 "O5'" B U   2 ? ? P     B U   2 ? ? OP1   B U   2 ? ? 127.86 110.70 17.16  1.20 N 
6 1 "O5'" B U   2 ? ? P     B U   2 ? ? OP2   B U   2 ? ? 91.90  105.70 -13.80 0.90 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 250 ? ? 61.28  60.61   
2 1 PHE A 366 ? ? -96.41 57.64   
3 1 ASP A 392 ? ? -94.06 57.99   
4 1 PHE A 441 ? ? -90.61 -60.43  
5 1 ILE A 498 ? ? -91.77 -64.10  
6 1 PHE A 649 ? ? -91.73 33.93   
7 1 LEU A 660 ? ? -91.43 50.20   
8 1 SER A 678 ? ? 179.85 151.10  
9 1 SER A 801 ? ? 56.63  -131.69 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 852 ? ? 0.115 'SIDE CHAIN' 
2 1 ARG A 853 ? ? 0.087 'SIDE CHAIN' 
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             LYS 
_pdbx_validate_main_chain_plane.auth_asym_id             A 
_pdbx_validate_main_chain_plane.auth_seq_id              838 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             ? 
_pdbx_validate_main_chain_plane.improper_torsion_angle   -10.26 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8Y9L 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8Y9L 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.0 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               86736 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Binary complex of Cas12h1 with crRNA' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        8Y9L 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8Y9L 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8Y9L 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A LYS 2   ? A LYS 2   
3   1 Y 1 A VAL 3   ? A VAL 3   
4   1 Y 1 A PHE 103 ? A PHE 103 
5   1 Y 1 A ALA 104 ? A ALA 104 
6   1 Y 1 A LEU 105 ? A LEU 105 
7   1 Y 1 A ARG 106 ? A ARG 106 
8   1 Y 1 A ASP 107 ? A ASP 107 
9   1 Y 1 A LYS 108 ? A LYS 108 
10  1 Y 1 A ALA 109 ? A ALA 109 
11  1 Y 1 A LYS 110 ? A LYS 110 
12  1 Y 1 A TYR 111 ? A TYR 111 
13  1 Y 1 A SER 112 ? A SER 112 
14  1 Y 1 A GLY 113 ? A GLY 113 
15  1 Y 1 A ALA 114 ? A ALA 114 
16  1 Y 1 A LYS 115 ? A LYS 115 
17  1 Y 1 A ARG 116 ? A ARG 116 
18  1 Y 1 A GLU 117 ? A GLU 117 
19  1 Y 1 A PHE 118 ? A PHE 118 
20  1 Y 1 A ILE 119 ? A ILE 119 
21  1 Y 1 A GLU 120 ? A GLU 120 
22  1 Y 1 A GLY 121 ? A GLY 121 
23  1 Y 1 A LEU 122 ? A LEU 122 
24  1 Y 1 A ALA 123 ? A ALA 123 
25  1 Y 1 A THR 124 ? A THR 124 
26  1 Y 1 A MET 125 ? A MET 125 
27  1 Y 1 A PRO 126 ? A PRO 126 
28  1 Y 1 A LEU 127 ? A LEU 127 
29  1 Y 1 A ASP 128 ? A ASP 128 
30  1 Y 1 A LYS 129 ? A LYS 129 
31  1 Y 1 A ILE 130 ? A ILE 130 
32  1 Y 1 A ILE 131 ? A ILE 131 
33  1 Y 1 A GLU 132 ? A GLU 132 
34  1 Y 1 A ARG 133 ? A ARG 133 
35  1 Y 1 A ILE 134 ? A ILE 134 
36  1 Y 1 A ARG 135 ? A ARG 135 
37  1 Y 1 A GLN 136 ? A GLN 136 
38  1 Y 1 A ASP 137 ? A ASP 137 
39  1 Y 1 A GLU 138 ? A GLU 138 
40  1 Y 1 A GLN 139 ? A GLN 139 
41  1 Y 1 A LEU 140 ? A LEU 140 
42  1 Y 1 A SER 141 ? A SER 141 
43  1 Y 1 A LYS 142 ? A LYS 142 
44  1 Y 1 A ILE 143 ? A ILE 143 
45  1 Y 1 A PRO 144 ? A PRO 144 
46  1 Y 1 A ALA 145 ? A ALA 145 
47  1 Y 1 A GLU 146 ? A GLU 146 
48  1 Y 1 A GLU 147 ? A GLU 147 
49  1 Y 1 A TRP 148 ? A TRP 148 
50  1 Y 1 A LEU 149 ? A LEU 149 
51  1 Y 1 A ILE 150 ? A ILE 150 
52  1 Y 1 A LEU 151 ? A LEU 151 
53  1 Y 1 A GLY 152 ? A GLY 152 
54  1 Y 1 A ALA 153 ? A ALA 153 
55  1 Y 1 A GLU 154 ? A GLU 154 
56  1 Y 1 A TYR 155 ? A TYR 155 
57  1 Y 1 A SER 156 ? A SER 156 
58  1 Y 1 A PRO 157 ? A PRO 157 
59  1 Y 1 A GLU 158 ? A GLU 158 
60  1 Y 1 A GLU 159 ? A GLU 159 
61  1 Y 1 A ILE 160 ? A ILE 160 
62  1 Y 1 A TRP 161 ? A TRP 161 
63  1 Y 1 A GLU 162 ? A GLU 162 
64  1 Y 1 A GLN 163 ? A GLN 163 
65  1 Y 1 A VAL 164 ? A VAL 164 
66  1 Y 1 A ALA 165 ? A ALA 165 
67  1 Y 1 A PRO 166 ? A PRO 166 
68  1 Y 1 A ARG 167 ? A ARG 167 
69  1 Y 1 A ILE 168 ? A ILE 168 
70  1 Y 1 A VAL 169 ? A VAL 169 
71  1 Y 1 A ASN 170 ? A ASN 170 
72  1 Y 1 A VAL 171 ? A VAL 171 
73  1 Y 1 A ASP 172 ? A ASP 172 
74  1 Y 1 A ARG 173 ? A ARG 173 
75  1 Y 1 A PRO 616 ? A PRO 616 
76  1 Y 1 A GLY 617 ? A GLY 617 
77  1 Y 1 A GLU 618 ? A GLU 618 
78  1 Y 1 A GLN 619 ? A GLN 619 
79  1 Y 1 A SER 620 ? A SER 620 
80  1 Y 1 A PRO 621 ? A PRO 621 
81  1 Y 1 A LYS 622 ? A LYS 622 
82  1 Y 1 A GLU 623 ? A GLU 623 
83  1 Y 1 A ALA 624 ? A ALA 624 
84  1 Y 1 A LYS 625 ? A LYS 625 
85  1 Y 1 A PHE 626 ? A PHE 626 
86  1 Y 1 A GLY 662 ? A GLY 662 
87  1 Y 1 A PRO 663 ? A PRO 663 
88  1 Y 1 A SER 664 ? A SER 664 
89  1 Y 1 A ASP 665 ? A ASP 665 
90  1 Y 1 A SER 666 ? A SER 666 
91  1 Y 1 A ASP 667 ? A ASP 667 
92  1 Y 1 A SER 668 ? A SER 668 
93  1 Y 1 A ARG 669 ? A ARG 669 
94  1 Y 1 A ASN 670 ? A ASN 670 
95  1 Y 1 A LYS 764 ? A LYS 764 
96  1 Y 1 A ALA 765 ? A ALA 765 
97  1 Y 1 A PRO 766 ? A PRO 766 
98  1 Y 1 A GLU 767 ? A GLU 767 
99  1 Y 1 A LYS 768 ? A LYS 768 
100 1 Y 1 A LYS 769 ? A LYS 769 
101 1 Y 1 A ASN 770 ? A ASN 770 
102 1 Y 1 A ASP 771 ? A ASP 771 
103 1 Y 1 A GLU 772 ? A GLU 772 
104 1 Y 1 A LYS 773 ? A LYS 773 
105 1 Y 1 A LYS 774 ? A LYS 774 
106 1 Y 1 A GLU 775 ? A GLU 775 
107 1 Y 1 A GLY 776 ? A GLY 776 
108 1 Y 1 A ASP 777 ? A ASP 777 
109 1 Y 1 A LYS 810 ? A LYS 810 
110 1 Y 1 A ARG 811 ? A ARG 811 
111 1 Y 1 A PRO 812 ? A PRO 812 
112 1 Y 1 A LYS 813 ? A LYS 813 
113 1 Y 1 A ASP 814 ? A ASP 814 
114 1 Y 1 B A   6   ? B A   42  
115 1 Y 1 B U   7   ? B U   43  
116 1 Y 1 B C   8   ? B C   44  
117 1 Y 1 B A   9   ? B A   45  
118 1 Y 1 B A   10  ? B A   46  
119 1 Y 1 B U   11  ? B U   47  
120 1 Y 1 B G   12  ? B G   48  
121 1 Y 1 B G   13  ? B G   49  
122 1 Y 1 B A   14  ? B A   50  
123 1 Y 1 B A   15  ? B A   51  
124 1 Y 1 B U   16  ? B U   52  
125 1 Y 1 B A   17  ? B A   53  
126 1 Y 1 B U   18  ? B U   54  
127 1 Y 1 B A   19  ? B A   55  
128 1 Y 1 B G   20  ? B G   56  
129 1 Y 1 B C   21  ? B C   57  
130 1 Y 1 B A   22  ? B A   58  
131 1 Y 1 B A   23  ? B A   59  
132 1 Y 1 B G   24  ? B G   60  
133 1 Y 1 B C   25  ? B C   61  
134 1 Y 1 B U   26  ? B U   62  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O  N N 1   
A   P      P  N N 2   
A   OP1    O  N N 3   
A   OP2    O  N N 4   
A   "O5'"  O  N N 5   
A   "C5'"  C  N N 6   
A   "C4'"  C  N R 7   
A   "O4'"  O  N N 8   
A   "C3'"  C  N S 9   
A   "O3'"  O  N N 10  
A   "C2'"  C  N R 11  
A   "O2'"  O  N N 12  
A   "C1'"  C  N R 13  
A   N9     N  Y N 14  
A   C8     C  Y N 15  
A   N7     N  Y N 16  
A   C5     C  Y N 17  
A   C6     C  Y N 18  
A   N6     N  N N 19  
A   N1     N  Y N 20  
A   C2     C  Y N 21  
A   N3     N  Y N 22  
A   C4     C  Y N 23  
A   HOP3   H  N N 24  
A   HOP2   H  N N 25  
A   "H5'"  H  N N 26  
A   "H5''" H  N N 27  
A   "H4'"  H  N N 28  
A   "H3'"  H  N N 29  
A   "HO3'" H  N N 30  
A   "H2'"  H  N N 31  
A   "HO2'" H  N N 32  
A   "H1'"  H  N N 33  
A   H8     H  N N 34  
A   H61    H  N N 35  
A   H62    H  N N 36  
A   H2     H  N N 37  
ALA N      N  N N 38  
ALA CA     C  N S 39  
ALA C      C  N N 40  
ALA O      O  N N 41  
ALA CB     C  N N 42  
ALA OXT    O  N N 43  
ALA H      H  N N 44  
ALA H2     H  N N 45  
ALA HA     H  N N 46  
ALA HB1    H  N N 47  
ALA HB2    H  N N 48  
ALA HB3    H  N N 49  
ALA HXT    H  N N 50  
ARG N      N  N N 51  
ARG CA     C  N S 52  
ARG C      C  N N 53  
ARG O      O  N N 54  
ARG CB     C  N N 55  
ARG CG     C  N N 56  
ARG CD     C  N N 57  
ARG NE     N  N N 58  
ARG CZ     C  N N 59  
ARG NH1    N  N N 60  
ARG NH2    N  N N 61  
ARG OXT    O  N N 62  
ARG H      H  N N 63  
ARG H2     H  N N 64  
ARG HA     H  N N 65  
ARG HB2    H  N N 66  
ARG HB3    H  N N 67  
ARG HG2    H  N N 68  
ARG HG3    H  N N 69  
ARG HD2    H  N N 70  
ARG HD3    H  N N 71  
ARG HE     H  N N 72  
ARG HH11   H  N N 73  
ARG HH12   H  N N 74  
ARG HH21   H  N N 75  
ARG HH22   H  N N 76  
ARG HXT    H  N N 77  
ASN N      N  N N 78  
ASN CA     C  N S 79  
ASN C      C  N N 80  
ASN O      O  N N 81  
ASN CB     C  N N 82  
ASN CG     C  N N 83  
ASN OD1    O  N N 84  
ASN ND2    N  N N 85  
ASN OXT    O  N N 86  
ASN H      H  N N 87  
ASN H2     H  N N 88  
ASN HA     H  N N 89  
ASN HB2    H  N N 90  
ASN HB3    H  N N 91  
ASN HD21   H  N N 92  
ASN HD22   H  N N 93  
ASN HXT    H  N N 94  
ASP N      N  N N 95  
ASP CA     C  N S 96  
ASP C      C  N N 97  
ASP O      O  N N 98  
ASP CB     C  N N 99  
ASP CG     C  N N 100 
ASP OD1    O  N N 101 
ASP OD2    O  N N 102 
ASP OXT    O  N N 103 
ASP H      H  N N 104 
ASP H2     H  N N 105 
ASP HA     H  N N 106 
ASP HB2    H  N N 107 
ASP HB3    H  N N 108 
ASP HD2    H  N N 109 
ASP HXT    H  N N 110 
C   OP3    O  N N 111 
C   P      P  N N 112 
C   OP1    O  N N 113 
C   OP2    O  N N 114 
C   "O5'"  O  N N 115 
C   "C5'"  C  N N 116 
C   "C4'"  C  N R 117 
C   "O4'"  O  N N 118 
C   "C3'"  C  N S 119 
C   "O3'"  O  N N 120 
C   "C2'"  C  N R 121 
C   "O2'"  O  N N 122 
C   "C1'"  C  N R 123 
C   N1     N  N N 124 
C   C2     C  N N 125 
C   O2     O  N N 126 
C   N3     N  N N 127 
C   C4     C  N N 128 
C   N4     N  N N 129 
C   C5     C  N N 130 
C   C6     C  N N 131 
C   HOP3   H  N N 132 
C   HOP2   H  N N 133 
C   "H5'"  H  N N 134 
C   "H5''" H  N N 135 
C   "H4'"  H  N N 136 
C   "H3'"  H  N N 137 
C   "HO3'" H  N N 138 
C   "H2'"  H  N N 139 
C   "HO2'" H  N N 140 
C   "H1'"  H  N N 141 
C   H41    H  N N 142 
C   H42    H  N N 143 
C   H5     H  N N 144 
C   H6     H  N N 145 
CYS N      N  N N 146 
CYS CA     C  N R 147 
CYS C      C  N N 148 
CYS O      O  N N 149 
CYS CB     C  N N 150 
CYS SG     S  N N 151 
CYS OXT    O  N N 152 
CYS H      H  N N 153 
CYS H2     H  N N 154 
CYS HA     H  N N 155 
CYS HB2    H  N N 156 
CYS HB3    H  N N 157 
CYS HG     H  N N 158 
CYS HXT    H  N N 159 
G   OP3    O  N N 160 
G   P      P  N N 161 
G   OP1    O  N N 162 
G   OP2    O  N N 163 
G   "O5'"  O  N N 164 
G   "C5'"  C  N N 165 
G   "C4'"  C  N R 166 
G   "O4'"  O  N N 167 
G   "C3'"  C  N S 168 
G   "O3'"  O  N N 169 
G   "C2'"  C  N R 170 
G   "O2'"  O  N N 171 
G   "C1'"  C  N R 172 
G   N9     N  Y N 173 
G   C8     C  Y N 174 
G   N7     N  Y N 175 
G   C5     C  Y N 176 
G   C6     C  N N 177 
G   O6     O  N N 178 
G   N1     N  N N 179 
G   C2     C  N N 180 
G   N2     N  N N 181 
G   N3     N  N N 182 
G   C4     C  Y N 183 
G   HOP3   H  N N 184 
G   HOP2   H  N N 185 
G   "H5'"  H  N N 186 
G   "H5''" H  N N 187 
G   "H4'"  H  N N 188 
G   "H3'"  H  N N 189 
G   "HO3'" H  N N 190 
G   "H2'"  H  N N 191 
G   "HO2'" H  N N 192 
G   "H1'"  H  N N 193 
G   H8     H  N N 194 
G   H1     H  N N 195 
G   H21    H  N N 196 
G   H22    H  N N 197 
GLN N      N  N N 198 
GLN CA     C  N S 199 
GLN C      C  N N 200 
GLN O      O  N N 201 
GLN CB     C  N N 202 
GLN CG     C  N N 203 
GLN CD     C  N N 204 
GLN OE1    O  N N 205 
GLN NE2    N  N N 206 
GLN OXT    O  N N 207 
GLN H      H  N N 208 
GLN H2     H  N N 209 
GLN HA     H  N N 210 
GLN HB2    H  N N 211 
GLN HB3    H  N N 212 
GLN HG2    H  N N 213 
GLN HG3    H  N N 214 
GLN HE21   H  N N 215 
GLN HE22   H  N N 216 
GLN HXT    H  N N 217 
GLU N      N  N N 218 
GLU CA     C  N S 219 
GLU C      C  N N 220 
GLU O      O  N N 221 
GLU CB     C  N N 222 
GLU CG     C  N N 223 
GLU CD     C  N N 224 
GLU OE1    O  N N 225 
GLU OE2    O  N N 226 
GLU OXT    O  N N 227 
GLU H      H  N N 228 
GLU H2     H  N N 229 
GLU HA     H  N N 230 
GLU HB2    H  N N 231 
GLU HB3    H  N N 232 
GLU HG2    H  N N 233 
GLU HG3    H  N N 234 
GLU HE2    H  N N 235 
GLU HXT    H  N N 236 
GLY N      N  N N 237 
GLY CA     C  N N 238 
GLY C      C  N N 239 
GLY O      O  N N 240 
GLY OXT    O  N N 241 
GLY H      H  N N 242 
GLY H2     H  N N 243 
GLY HA2    H  N N 244 
GLY HA3    H  N N 245 
GLY HXT    H  N N 246 
HIS N      N  N N 247 
HIS CA     C  N S 248 
HIS C      C  N N 249 
HIS O      O  N N 250 
HIS CB     C  N N 251 
HIS CG     C  Y N 252 
HIS ND1    N  Y N 253 
HIS CD2    C  Y N 254 
HIS CE1    C  Y N 255 
HIS NE2    N  Y N 256 
HIS OXT    O  N N 257 
HIS H      H  N N 258 
HIS H2     H  N N 259 
HIS HA     H  N N 260 
HIS HB2    H  N N 261 
HIS HB3    H  N N 262 
HIS HD1    H  N N 263 
HIS HD2    H  N N 264 
HIS HE1    H  N N 265 
HIS HE2    H  N N 266 
HIS HXT    H  N N 267 
ILE N      N  N N 268 
ILE CA     C  N S 269 
ILE C      C  N N 270 
ILE O      O  N N 271 
ILE CB     C  N S 272 
ILE CG1    C  N N 273 
ILE CG2    C  N N 274 
ILE CD1    C  N N 275 
ILE OXT    O  N N 276 
ILE H      H  N N 277 
ILE H2     H  N N 278 
ILE HA     H  N N 279 
ILE HB     H  N N 280 
ILE HG12   H  N N 281 
ILE HG13   H  N N 282 
ILE HG21   H  N N 283 
ILE HG22   H  N N 284 
ILE HG23   H  N N 285 
ILE HD11   H  N N 286 
ILE HD12   H  N N 287 
ILE HD13   H  N N 288 
ILE HXT    H  N N 289 
LEU N      N  N N 290 
LEU CA     C  N S 291 
LEU C      C  N N 292 
LEU O      O  N N 293 
LEU CB     C  N N 294 
LEU CG     C  N N 295 
LEU CD1    C  N N 296 
LEU CD2    C  N N 297 
LEU OXT    O  N N 298 
LEU H      H  N N 299 
LEU H2     H  N N 300 
LEU HA     H  N N 301 
LEU HB2    H  N N 302 
LEU HB3    H  N N 303 
LEU HG     H  N N 304 
LEU HD11   H  N N 305 
LEU HD12   H  N N 306 
LEU HD13   H  N N 307 
LEU HD21   H  N N 308 
LEU HD22   H  N N 309 
LEU HD23   H  N N 310 
LEU HXT    H  N N 311 
LYS N      N  N N 312 
LYS CA     C  N S 313 
LYS C      C  N N 314 
LYS O      O  N N 315 
LYS CB     C  N N 316 
LYS CG     C  N N 317 
LYS CD     C  N N 318 
LYS CE     C  N N 319 
LYS NZ     N  N N 320 
LYS OXT    O  N N 321 
LYS H      H  N N 322 
LYS H2     H  N N 323 
LYS HA     H  N N 324 
LYS HB2    H  N N 325 
LYS HB3    H  N N 326 
LYS HG2    H  N N 327 
LYS HG3    H  N N 328 
LYS HD2    H  N N 329 
LYS HD3    H  N N 330 
LYS HE2    H  N N 331 
LYS HE3    H  N N 332 
LYS HZ1    H  N N 333 
LYS HZ2    H  N N 334 
LYS HZ3    H  N N 335 
LYS HXT    H  N N 336 
MET N      N  N N 337 
MET CA     C  N S 338 
MET C      C  N N 339 
MET O      O  N N 340 
MET CB     C  N N 341 
MET CG     C  N N 342 
MET SD     S  N N 343 
MET CE     C  N N 344 
MET OXT    O  N N 345 
MET H      H  N N 346 
MET H2     H  N N 347 
MET HA     H  N N 348 
MET HB2    H  N N 349 
MET HB3    H  N N 350 
MET HG2    H  N N 351 
MET HG3    H  N N 352 
MET HE1    H  N N 353 
MET HE2    H  N N 354 
MET HE3    H  N N 355 
MET HXT    H  N N 356 
MG  MG     MG N N 357 
PHE N      N  N N 358 
PHE CA     C  N S 359 
PHE C      C  N N 360 
PHE O      O  N N 361 
PHE CB     C  N N 362 
PHE CG     C  Y N 363 
PHE CD1    C  Y N 364 
PHE CD2    C  Y N 365 
PHE CE1    C  Y N 366 
PHE CE2    C  Y N 367 
PHE CZ     C  Y N 368 
PHE OXT    O  N N 369 
PHE H      H  N N 370 
PHE H2     H  N N 371 
PHE HA     H  N N 372 
PHE HB2    H  N N 373 
PHE HB3    H  N N 374 
PHE HD1    H  N N 375 
PHE HD2    H  N N 376 
PHE HE1    H  N N 377 
PHE HE2    H  N N 378 
PHE HZ     H  N N 379 
PHE HXT    H  N N 380 
PRO N      N  N N 381 
PRO CA     C  N S 382 
PRO C      C  N N 383 
PRO O      O  N N 384 
PRO CB     C  N N 385 
PRO CG     C  N N 386 
PRO CD     C  N N 387 
PRO OXT    O  N N 388 
PRO H      H  N N 389 
PRO HA     H  N N 390 
PRO HB2    H  N N 391 
PRO HB3    H  N N 392 
PRO HG2    H  N N 393 
PRO HG3    H  N N 394 
PRO HD2    H  N N 395 
PRO HD3    H  N N 396 
PRO HXT    H  N N 397 
SER N      N  N N 398 
SER CA     C  N S 399 
SER C      C  N N 400 
SER O      O  N N 401 
SER CB     C  N N 402 
SER OG     O  N N 403 
SER OXT    O  N N 404 
SER H      H  N N 405 
SER H2     H  N N 406 
SER HA     H  N N 407 
SER HB2    H  N N 408 
SER HB3    H  N N 409 
SER HG     H  N N 410 
SER HXT    H  N N 411 
THR N      N  N N 412 
THR CA     C  N S 413 
THR C      C  N N 414 
THR O      O  N N 415 
THR CB     C  N R 416 
THR OG1    O  N N 417 
THR CG2    C  N N 418 
THR OXT    O  N N 419 
THR H      H  N N 420 
THR H2     H  N N 421 
THR HA     H  N N 422 
THR HB     H  N N 423 
THR HG1    H  N N 424 
THR HG21   H  N N 425 
THR HG22   H  N N 426 
THR HG23   H  N N 427 
THR HXT    H  N N 428 
TRP N      N  N N 429 
TRP CA     C  N S 430 
TRP C      C  N N 431 
TRP O      O  N N 432 
TRP CB     C  N N 433 
TRP CG     C  Y N 434 
TRP CD1    C  Y N 435 
TRP CD2    C  Y N 436 
TRP NE1    N  Y N 437 
TRP CE2    C  Y N 438 
TRP CE3    C  Y N 439 
TRP CZ2    C  Y N 440 
TRP CZ3    C  Y N 441 
TRP CH2    C  Y N 442 
TRP OXT    O  N N 443 
TRP H      H  N N 444 
TRP H2     H  N N 445 
TRP HA     H  N N 446 
TRP HB2    H  N N 447 
TRP HB3    H  N N 448 
TRP HD1    H  N N 449 
TRP HE1    H  N N 450 
TRP HE3    H  N N 451 
TRP HZ2    H  N N 452 
TRP HZ3    H  N N 453 
TRP HH2    H  N N 454 
TRP HXT    H  N N 455 
TYR N      N  N N 456 
TYR CA     C  N S 457 
TYR C      C  N N 458 
TYR O      O  N N 459 
TYR CB     C  N N 460 
TYR CG     C  Y N 461 
TYR CD1    C  Y N 462 
TYR CD2    C  Y N 463 
TYR CE1    C  Y N 464 
TYR CE2    C  Y N 465 
TYR CZ     C  Y N 466 
TYR OH     O  N N 467 
TYR OXT    O  N N 468 
TYR H      H  N N 469 
TYR H2     H  N N 470 
TYR HA     H  N N 471 
TYR HB2    H  N N 472 
TYR HB3    H  N N 473 
TYR HD1    H  N N 474 
TYR HD2    H  N N 475 
TYR HE1    H  N N 476 
TYR HE2    H  N N 477 
TYR HH     H  N N 478 
TYR HXT    H  N N 479 
U   OP3    O  N N 480 
U   P      P  N N 481 
U   OP1    O  N N 482 
U   OP2    O  N N 483 
U   "O5'"  O  N N 484 
U   "C5'"  C  N N 485 
U   "C4'"  C  N R 486 
U   "O4'"  O  N N 487 
U   "C3'"  C  N S 488 
U   "O3'"  O  N N 489 
U   "C2'"  C  N R 490 
U   "O2'"  O  N N 491 
U   "C1'"  C  N R 492 
U   N1     N  N N 493 
U   C2     C  N N 494 
U   O2     O  N N 495 
U   N3     N  N N 496 
U   C4     C  N N 497 
U   O4     O  N N 498 
U   C5     C  N N 499 
U   C6     C  N N 500 
U   HOP3   H  N N 501 
U   HOP2   H  N N 502 
U   "H5'"  H  N N 503 
U   "H5''" H  N N 504 
U   "H4'"  H  N N 505 
U   "H3'"  H  N N 506 
U   "HO3'" H  N N 507 
U   "H2'"  H  N N 508 
U   "HO2'" H  N N 509 
U   "H1'"  H  N N 510 
U   H3     H  N N 511 
U   H5     H  N N 512 
U   H6     H  N N 513 
VAL N      N  N N 514 
VAL CA     C  N S 515 
VAL C      C  N N 516 
VAL O      O  N N 517 
VAL CB     C  N N 518 
VAL CG1    C  N N 519 
VAL CG2    C  N N 520 
VAL OXT    O  N N 521 
VAL H      H  N N 522 
VAL H2     H  N N 523 
VAL HA     H  N N 524 
VAL HB     H  N N 525 
VAL HG11   H  N N 526 
VAL HG12   H  N N 527 
VAL HG13   H  N N 528 
VAL HG21   H  N N 529 
VAL HG22   H  N N 530 
VAL HG23   H  N N 531 
VAL HXT    H  N N 532 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
C   OP3   P      sing N N 109 
C   OP3   HOP3   sing N N 110 
C   P     OP1    doub N N 111 
C   P     OP2    sing N N 112 
C   P     "O5'"  sing N N 113 
C   OP2   HOP2   sing N N 114 
C   "O5'" "C5'"  sing N N 115 
C   "C5'" "C4'"  sing N N 116 
C   "C5'" "H5'"  sing N N 117 
C   "C5'" "H5''" sing N N 118 
C   "C4'" "O4'"  sing N N 119 
C   "C4'" "C3'"  sing N N 120 
C   "C4'" "H4'"  sing N N 121 
C   "O4'" "C1'"  sing N N 122 
C   "C3'" "O3'"  sing N N 123 
C   "C3'" "C2'"  sing N N 124 
C   "C3'" "H3'"  sing N N 125 
C   "O3'" "HO3'" sing N N 126 
C   "C2'" "O2'"  sing N N 127 
C   "C2'" "C1'"  sing N N 128 
C   "C2'" "H2'"  sing N N 129 
C   "O2'" "HO2'" sing N N 130 
C   "C1'" N1     sing N N 131 
C   "C1'" "H1'"  sing N N 132 
C   N1    C2     sing N N 133 
C   N1    C6     sing N N 134 
C   C2    O2     doub N N 135 
C   C2    N3     sing N N 136 
C   N3    C4     doub N N 137 
C   C4    N4     sing N N 138 
C   C4    C5     sing N N 139 
C   N4    H41    sing N N 140 
C   N4    H42    sing N N 141 
C   C5    C6     doub N N 142 
C   C5    H5     sing N N 143 
C   C6    H6     sing N N 144 
CYS N     CA     sing N N 145 
CYS N     H      sing N N 146 
CYS N     H2     sing N N 147 
CYS CA    C      sing N N 148 
CYS CA    CB     sing N N 149 
CYS CA    HA     sing N N 150 
CYS C     O      doub N N 151 
CYS C     OXT    sing N N 152 
CYS CB    SG     sing N N 153 
CYS CB    HB2    sing N N 154 
CYS CB    HB3    sing N N 155 
CYS SG    HG     sing N N 156 
CYS OXT   HXT    sing N N 157 
G   OP3   P      sing N N 158 
G   OP3   HOP3   sing N N 159 
G   P     OP1    doub N N 160 
G   P     OP2    sing N N 161 
G   P     "O5'"  sing N N 162 
G   OP2   HOP2   sing N N 163 
G   "O5'" "C5'"  sing N N 164 
G   "C5'" "C4'"  sing N N 165 
G   "C5'" "H5'"  sing N N 166 
G   "C5'" "H5''" sing N N 167 
G   "C4'" "O4'"  sing N N 168 
G   "C4'" "C3'"  sing N N 169 
G   "C4'" "H4'"  sing N N 170 
G   "O4'" "C1'"  sing N N 171 
G   "C3'" "O3'"  sing N N 172 
G   "C3'" "C2'"  sing N N 173 
G   "C3'" "H3'"  sing N N 174 
G   "O3'" "HO3'" sing N N 175 
G   "C2'" "O2'"  sing N N 176 
G   "C2'" "C1'"  sing N N 177 
G   "C2'" "H2'"  sing N N 178 
G   "O2'" "HO2'" sing N N 179 
G   "C1'" N9     sing N N 180 
G   "C1'" "H1'"  sing N N 181 
G   N9    C8     sing Y N 182 
G   N9    C4     sing Y N 183 
G   C8    N7     doub Y N 184 
G   C8    H8     sing N N 185 
G   N7    C5     sing Y N 186 
G   C5    C6     sing N N 187 
G   C5    C4     doub Y N 188 
G   C6    O6     doub N N 189 
G   C6    N1     sing N N 190 
G   N1    C2     sing N N 191 
G   N1    H1     sing N N 192 
G   C2    N2     sing N N 193 
G   C2    N3     doub N N 194 
G   N2    H21    sing N N 195 
G   N2    H22    sing N N 196 
G   N3    C4     sing N N 197 
GLN N     CA     sing N N 198 
GLN N     H      sing N N 199 
GLN N     H2     sing N N 200 
GLN CA    C      sing N N 201 
GLN CA    CB     sing N N 202 
GLN CA    HA     sing N N 203 
GLN C     O      doub N N 204 
GLN C     OXT    sing N N 205 
GLN CB    CG     sing N N 206 
GLN CB    HB2    sing N N 207 
GLN CB    HB3    sing N N 208 
GLN CG    CD     sing N N 209 
GLN CG    HG2    sing N N 210 
GLN CG    HG3    sing N N 211 
GLN CD    OE1    doub N N 212 
GLN CD    NE2    sing N N 213 
GLN NE2   HE21   sing N N 214 
GLN NE2   HE22   sing N N 215 
GLN OXT   HXT    sing N N 216 
GLU N     CA     sing N N 217 
GLU N     H      sing N N 218 
GLU N     H2     sing N N 219 
GLU CA    C      sing N N 220 
GLU CA    CB     sing N N 221 
GLU CA    HA     sing N N 222 
GLU C     O      doub N N 223 
GLU C     OXT    sing N N 224 
GLU CB    CG     sing N N 225 
GLU CB    HB2    sing N N 226 
GLU CB    HB3    sing N N 227 
GLU CG    CD     sing N N 228 
GLU CG    HG2    sing N N 229 
GLU CG    HG3    sing N N 230 
GLU CD    OE1    doub N N 231 
GLU CD    OE2    sing N N 232 
GLU OE2   HE2    sing N N 233 
GLU OXT   HXT    sing N N 234 
GLY N     CA     sing N N 235 
GLY N     H      sing N N 236 
GLY N     H2     sing N N 237 
GLY CA    C      sing N N 238 
GLY CA    HA2    sing N N 239 
GLY CA    HA3    sing N N 240 
GLY C     O      doub N N 241 
GLY C     OXT    sing N N 242 
GLY OXT   HXT    sing N N 243 
HIS N     CA     sing N N 244 
HIS N     H      sing N N 245 
HIS N     H2     sing N N 246 
HIS CA    C      sing N N 247 
HIS CA    CB     sing N N 248 
HIS CA    HA     sing N N 249 
HIS C     O      doub N N 250 
HIS C     OXT    sing N N 251 
HIS CB    CG     sing N N 252 
HIS CB    HB2    sing N N 253 
HIS CB    HB3    sing N N 254 
HIS CG    ND1    sing Y N 255 
HIS CG    CD2    doub Y N 256 
HIS ND1   CE1    doub Y N 257 
HIS ND1   HD1    sing N N 258 
HIS CD2   NE2    sing Y N 259 
HIS CD2   HD2    sing N N 260 
HIS CE1   NE2    sing Y N 261 
HIS CE1   HE1    sing N N 262 
HIS NE2   HE2    sing N N 263 
HIS OXT   HXT    sing N N 264 
ILE N     CA     sing N N 265 
ILE N     H      sing N N 266 
ILE N     H2     sing N N 267 
ILE CA    C      sing N N 268 
ILE CA    CB     sing N N 269 
ILE CA    HA     sing N N 270 
ILE C     O      doub N N 271 
ILE C     OXT    sing N N 272 
ILE CB    CG1    sing N N 273 
ILE CB    CG2    sing N N 274 
ILE CB    HB     sing N N 275 
ILE CG1   CD1    sing N N 276 
ILE CG1   HG12   sing N N 277 
ILE CG1   HG13   sing N N 278 
ILE CG2   HG21   sing N N 279 
ILE CG2   HG22   sing N N 280 
ILE CG2   HG23   sing N N 281 
ILE CD1   HD11   sing N N 282 
ILE CD1   HD12   sing N N 283 
ILE CD1   HD13   sing N N 284 
ILE OXT   HXT    sing N N 285 
LEU N     CA     sing N N 286 
LEU N     H      sing N N 287 
LEU N     H2     sing N N 288 
LEU CA    C      sing N N 289 
LEU CA    CB     sing N N 290 
LEU CA    HA     sing N N 291 
LEU C     O      doub N N 292 
LEU C     OXT    sing N N 293 
LEU CB    CG     sing N N 294 
LEU CB    HB2    sing N N 295 
LEU CB    HB3    sing N N 296 
LEU CG    CD1    sing N N 297 
LEU CG    CD2    sing N N 298 
LEU CG    HG     sing N N 299 
LEU CD1   HD11   sing N N 300 
LEU CD1   HD12   sing N N 301 
LEU CD1   HD13   sing N N 302 
LEU CD2   HD21   sing N N 303 
LEU CD2   HD22   sing N N 304 
LEU CD2   HD23   sing N N 305 
LEU OXT   HXT    sing N N 306 
LYS N     CA     sing N N 307 
LYS N     H      sing N N 308 
LYS N     H2     sing N N 309 
LYS CA    C      sing N N 310 
LYS CA    CB     sing N N 311 
LYS CA    HA     sing N N 312 
LYS C     O      doub N N 313 
LYS C     OXT    sing N N 314 
LYS CB    CG     sing N N 315 
LYS CB    HB2    sing N N 316 
LYS CB    HB3    sing N N 317 
LYS CG    CD     sing N N 318 
LYS CG    HG2    sing N N 319 
LYS CG    HG3    sing N N 320 
LYS CD    CE     sing N N 321 
LYS CD    HD2    sing N N 322 
LYS CD    HD3    sing N N 323 
LYS CE    NZ     sing N N 324 
LYS CE    HE2    sing N N 325 
LYS CE    HE3    sing N N 326 
LYS NZ    HZ1    sing N N 327 
LYS NZ    HZ2    sing N N 328 
LYS NZ    HZ3    sing N N 329 
LYS OXT   HXT    sing N N 330 
MET N     CA     sing N N 331 
MET N     H      sing N N 332 
MET N     H2     sing N N 333 
MET CA    C      sing N N 334 
MET CA    CB     sing N N 335 
MET CA    HA     sing N N 336 
MET C     O      doub N N 337 
MET C     OXT    sing N N 338 
MET CB    CG     sing N N 339 
MET CB    HB2    sing N N 340 
MET CB    HB3    sing N N 341 
MET CG    SD     sing N N 342 
MET CG    HG2    sing N N 343 
MET CG    HG3    sing N N 344 
MET SD    CE     sing N N 345 
MET CE    HE1    sing N N 346 
MET CE    HE2    sing N N 347 
MET CE    HE3    sing N N 348 
MET OXT   HXT    sing N N 349 
PHE N     CA     sing N N 350 
PHE N     H      sing N N 351 
PHE N     H2     sing N N 352 
PHE CA    C      sing N N 353 
PHE CA    CB     sing N N 354 
PHE CA    HA     sing N N 355 
PHE C     O      doub N N 356 
PHE C     OXT    sing N N 357 
PHE CB    CG     sing N N 358 
PHE CB    HB2    sing N N 359 
PHE CB    HB3    sing N N 360 
PHE CG    CD1    doub Y N 361 
PHE CG    CD2    sing Y N 362 
PHE CD1   CE1    sing Y N 363 
PHE CD1   HD1    sing N N 364 
PHE CD2   CE2    doub Y N 365 
PHE CD2   HD2    sing N N 366 
PHE CE1   CZ     doub Y N 367 
PHE CE1   HE1    sing N N 368 
PHE CE2   CZ     sing Y N 369 
PHE CE2   HE2    sing N N 370 
PHE CZ    HZ     sing N N 371 
PHE OXT   HXT    sing N N 372 
PRO N     CA     sing N N 373 
PRO N     CD     sing N N 374 
PRO N     H      sing N N 375 
PRO CA    C      sing N N 376 
PRO CA    CB     sing N N 377 
PRO CA    HA     sing N N 378 
PRO C     O      doub N N 379 
PRO C     OXT    sing N N 380 
PRO CB    CG     sing N N 381 
PRO CB    HB2    sing N N 382 
PRO CB    HB3    sing N N 383 
PRO CG    CD     sing N N 384 
PRO CG    HG2    sing N N 385 
PRO CG    HG3    sing N N 386 
PRO CD    HD2    sing N N 387 
PRO CD    HD3    sing N N 388 
PRO OXT   HXT    sing N N 389 
SER N     CA     sing N N 390 
SER N     H      sing N N 391 
SER N     H2     sing N N 392 
SER CA    C      sing N N 393 
SER CA    CB     sing N N 394 
SER CA    HA     sing N N 395 
SER C     O      doub N N 396 
SER C     OXT    sing N N 397 
SER CB    OG     sing N N 398 
SER CB    HB2    sing N N 399 
SER CB    HB3    sing N N 400 
SER OG    HG     sing N N 401 
SER OXT   HXT    sing N N 402 
THR N     CA     sing N N 403 
THR N     H      sing N N 404 
THR N     H2     sing N N 405 
THR CA    C      sing N N 406 
THR CA    CB     sing N N 407 
THR CA    HA     sing N N 408 
THR C     O      doub N N 409 
THR C     OXT    sing N N 410 
THR CB    OG1    sing N N 411 
THR CB    CG2    sing N N 412 
THR CB    HB     sing N N 413 
THR OG1   HG1    sing N N 414 
THR CG2   HG21   sing N N 415 
THR CG2   HG22   sing N N 416 
THR CG2   HG23   sing N N 417 
THR OXT   HXT    sing N N 418 
TRP N     CA     sing N N 419 
TRP N     H      sing N N 420 
TRP N     H2     sing N N 421 
TRP CA    C      sing N N 422 
TRP CA    CB     sing N N 423 
TRP CA    HA     sing N N 424 
TRP C     O      doub N N 425 
TRP C     OXT    sing N N 426 
TRP CB    CG     sing N N 427 
TRP CB    HB2    sing N N 428 
TRP CB    HB3    sing N N 429 
TRP CG    CD1    doub Y N 430 
TRP CG    CD2    sing Y N 431 
TRP CD1   NE1    sing Y N 432 
TRP CD1   HD1    sing N N 433 
TRP CD2   CE2    doub Y N 434 
TRP CD2   CE3    sing Y N 435 
TRP NE1   CE2    sing Y N 436 
TRP NE1   HE1    sing N N 437 
TRP CE2   CZ2    sing Y N 438 
TRP CE3   CZ3    doub Y N 439 
TRP CE3   HE3    sing N N 440 
TRP CZ2   CH2    doub Y N 441 
TRP CZ2   HZ2    sing N N 442 
TRP CZ3   CH2    sing Y N 443 
TRP CZ3   HZ3    sing N N 444 
TRP CH2   HH2    sing N N 445 
TRP OXT   HXT    sing N N 446 
TYR N     CA     sing N N 447 
TYR N     H      sing N N 448 
TYR N     H2     sing N N 449 
TYR CA    C      sing N N 450 
TYR CA    CB     sing N N 451 
TYR CA    HA     sing N N 452 
TYR C     O      doub N N 453 
TYR C     OXT    sing N N 454 
TYR CB    CG     sing N N 455 
TYR CB    HB2    sing N N 456 
TYR CB    HB3    sing N N 457 
TYR CG    CD1    doub Y N 458 
TYR CG    CD2    sing Y N 459 
TYR CD1   CE1    sing Y N 460 
TYR CD1   HD1    sing N N 461 
TYR CD2   CE2    doub Y N 462 
TYR CD2   HD2    sing N N 463 
TYR CE1   CZ     doub Y N 464 
TYR CE1   HE1    sing N N 465 
TYR CE2   CZ     sing Y N 466 
TYR CE2   HE2    sing N N 467 
TYR CZ    OH     sing N N 468 
TYR OH    HH     sing N N 469 
TYR OXT   HXT    sing N N 470 
U   OP3   P      sing N N 471 
U   OP3   HOP3   sing N N 472 
U   P     OP1    doub N N 473 
U   P     OP2    sing N N 474 
U   P     "O5'"  sing N N 475 
U   OP2   HOP2   sing N N 476 
U   "O5'" "C5'"  sing N N 477 
U   "C5'" "C4'"  sing N N 478 
U   "C5'" "H5'"  sing N N 479 
U   "C5'" "H5''" sing N N 480 
U   "C4'" "O4'"  sing N N 481 
U   "C4'" "C3'"  sing N N 482 
U   "C4'" "H4'"  sing N N 483 
U   "O4'" "C1'"  sing N N 484 
U   "C3'" "O3'"  sing N N 485 
U   "C3'" "C2'"  sing N N 486 
U   "C3'" "H3'"  sing N N 487 
U   "O3'" "HO3'" sing N N 488 
U   "C2'" "O2'"  sing N N 489 
U   "C2'" "C1'"  sing N N 490 
U   "C2'" "H2'"  sing N N 491 
U   "O2'" "HO2'" sing N N 492 
U   "C1'" N1     sing N N 493 
U   "C1'" "H1'"  sing N N 494 
U   N1    C2     sing N N 495 
U   N1    C6     sing N N 496 
U   C2    O2     doub N N 497 
U   C2    N3     sing N N 498 
U   N3    C4     sing N N 499 
U   N3    H3     sing N N 500 
U   C4    O4     doub N N 501 
U   C4    C5     sing N N 502 
U   C5    C6     doub N N 503 
U   C5    H5     sing N N 504 
U   C6    H6     sing N N 505 
VAL N     CA     sing N N 506 
VAL N     H      sing N N 507 
VAL N     H2     sing N N 508 
VAL CA    C      sing N N 509 
VAL CA    CB     sing N N 510 
VAL CA    HA     sing N N 511 
VAL C     O      doub N N 512 
VAL C     OXT    sing N N 513 
VAL CB    CG1    sing N N 514 
VAL CB    CG2    sing N N 515 
VAL CB    HB     sing N N 516 
VAL CG1   HG11   sing N N 517 
VAL CG1   HG12   sing N N 518 
VAL CG1   HG13   sing N N 519 
VAL CG2   HG21   sing N N 520 
VAL CG2   HG22   sing N N 521 
VAL CG2   HG23   sing N N 522 
VAL OXT   HXT    sing N N 523 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-02-07 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8Y9L 
_em_admin.last_update        2025-03-19 
_em_admin.map_release_date   2025-02-12 
_em_admin.title              'Cas12h1-crRNA binary complex' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    YES 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.1 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          32644 
_em_entity_assembly_naturalsource.organism             unidentified 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8Y9L 'double helix'        
8Y9L 'a-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B G 1  1_555 B C 36 1_555 -0.227 0.539  0.500  0.011  -21.678 0.703   1  B_G-35:C0_B   B -35 ? B 0   ? 19 1 
1 B U 2  1_555 B A 35 1_555 0.171  0.345  0.721  1.989  -13.237 -1.323  2  B_U-34:A-1_B  B -34 ? B -1  ? 20 1 
1 B G 3  1_555 B C 34 1_555 -0.681 0.531  0.240  -1.838 0.608   5.416   3  B_G-33:C-2_B  B -33 ? B -2  ? ?  1 
1 B C 4  1_555 B G 33 1_555 0.398  0.285  0.424  5.959  14.887  2.638   4  B_C-32:G-3_B  B -32 ? B -3  ? 19 1 
1 B U 5  1_555 B A 30 1_555 1.043  0.632  0.346  -5.286 -2.070  14.534  5  B_U-31:A-6_B  B -31 ? B -6  ? ?  1 
1 B G 6  1_555 B C 29 1_555 -1.179 0.403  0.601  12.505 -11.108 -7.819  6  B_G-30:C-7_B  B -30 ? B -7  ? ?  ? 
1 B G 7  1_555 B U 28 1_555 -2.846 -0.231 0.035  8.353  -14.222 4.043   7  B_G-29:U-8_B  B -29 ? B -8  ? 28 1 
1 B C 8  1_555 B G 27 1_555 0.422  0.101  0.189  12.879 -18.669 6.402   8  B_C-28:G-9_B  B -28 ? B -9  ? 19 1 
1 B C 9  1_555 B G 26 1_555 -0.629 0.030  0.089  3.235  -18.195 7.846   9  B_C-27:G-10_B B -27 ? B -10 ? 19 1 
1 B G 10 1_555 B A 25 1_555 -0.472 -3.707 -0.216 18.158 5.945   116.806 10 B_G-26:A-11_B B -26 ? B -11 ? ?  ? 
1 B C 11 1_555 B G 24 1_555 -0.343 0.213  -0.385 11.530 -25.506 -7.407  11 B_C-25:G-12_B B -25 ? B -12 ? 19 1 
1 B U 12 1_555 B G 23 1_555 1.389  0.218  -0.035 7.761  -20.269 5.700   12 B_U-24:G-13_B B -24 ? B -13 ? 28 1 
1 B C 13 1_555 B G 22 1_555 0.021  0.356  -0.484 9.162  -15.138 -0.065  13 B_C-23:G-14_B B -23 ? B -14 ? 19 1 
1 B U 14 1_555 B A 21 1_555 -0.031 0.055  0.941  -9.605 7.098   -5.047  14 B_U-22:A-15_B B -22 ? B -15 ? 20 1 
1 B C 15 1_555 B G 20 1_555 -0.422 -0.575 1.016  2.304  -8.536  -12.970 15 B_C-21:G-16_B B -21 ? B -16 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B G 1  1_555 B C 36 1_555 B U 2  1_555 B A 35 1_555 -0.448 -1.531 3.405  -2.328  -1.187   38.472   -2.164 0.376  3.470 -1.799  
3.528   38.558   1  BB_G-35U-34:A-1C0_BB    B -35 ? B 0   ? B -34 ? B -1  ? 
1 B U 2  1_555 B A 35 1_555 B G 3  1_555 B C 34 1_555 0.858  -1.405 3.263  7.557   4.132    27.389   -3.770 -0.023 3.141 8.464   
-15.482 28.686   2  BB_U-34G-33:C-2A-1_BB   B -34 ? B -1  ? B -33 ? B -2  ? 
1 B G 3  1_555 B C 34 1_555 B C 4  1_555 B G 33 1_555 0.047  -0.457 3.435  -0.162  14.903   31.510   -3.095 -0.105 2.929 25.720  
0.280   34.776   3  BB_G-33C-32:G-3C-2_BB   B -33 ? B -2  ? B -32 ? B -3  ? 
1 B U 5  1_555 B A 30 1_555 B G 6  1_555 B C 29 1_555 -1.294 -1.895 2.924  0.015   -2.200   12.923   -6.045 5.684  3.198 -9.684  
-0.066  13.109   4  BB_U-31G-30:C-7A-6_BB   B -31 ? B -6  ? B -30 ? B -7  ? 
1 B G 6  1_555 B C 29 1_555 B G 7  1_555 B U 28 1_555 0.332  -1.893 3.332  -3.583  7.380    28.656   -5.136 -1.351 2.711 14.538  
7.058   29.783   5  BB_G-30G-29:U-8C-7_BB   B -30 ? B -7  ? B -29 ? B -8  ? 
1 B G 7  1_555 B U 28 1_555 B C 8  1_555 B G 27 1_555 0.171  -0.935 3.381  -3.436  1.817    43.924   -1.421 -0.559 3.320 2.424   
4.583   44.087   6  BB_G-29C-28:G-9U-8_BB   B -29 ? B -8  ? B -28 ? B -9  ? 
1 B C 8  1_555 B G 27 1_555 B C 9  1_555 B G 26 1_555 0.204  -1.595 3.567  2.568   5.016    29.213   -4.215 0.169  3.260 9.830   
-5.032  29.740   7  BB_C-28C-27:G-10G-9_BB  B -28 ? B -9  ? B -27 ? B -10 ? 
1 B C 9  1_555 B G 26 1_555 B G 10 1_555 B A 25 1_555 0.725  3.538  0.271  165.636 -27.809  -145.648 -1.764 0.399  0.221 13.949  
83.081  -176.449 8  BB_C-27G-26:A-11G-10_BB B -27 ? B -10 ? B -26 ? B -11 ? 
1 B G 10 1_555 B A 25 1_555 B C 11 1_555 B G 24 1_555 -0.223 -3.618 -0.811 134.294 -109.430 136.089  -1.857 0.053  0.036 -54.870 
-67.337 177.471  9  BB_G-26C-25:G-12A-11_BB B -26 ? B -11 ? B -25 ? B -12 ? 
1 B C 11 1_555 B G 24 1_555 B U 12 1_555 B G 23 1_555 0.802  -1.291 3.677  -0.932  7.307    41.250   -2.637 -1.228 3.392 10.273  
1.310   41.874   10 BB_C-25U-24:G-13G-12_BB B -25 ? B -12 ? B -24 ? B -13 ? 
1 B U 12 1_555 B G 23 1_555 B C 13 1_555 B G 22 1_555 0.084  -1.900 3.314  6.897   5.236    26.951   -5.059 1.369  2.836 10.883  
-14.336 28.283   11 BB_U-24C-23:G-14G-13_BB B -24 ? B -13 ? B -23 ? B -14 ? 
1 B C 13 1_555 B G 22 1_555 B U 14 1_555 B A 21 1_555 -0.581 -1.820 3.997  -8.958  11.372   33.140   -4.808 -0.535 3.263 18.857  
14.854  36.082   12 BB_C-23U-22:A-15G-14_BB B -23 ? B -14 ? B -22 ? B -15 ? 
1 B U 14 1_555 B A 21 1_555 B C 15 1_555 B G 20 1_555 0.034  -1.624 3.077  3.604   3.532    26.694   -4.268 0.752  2.823 7.564   
-7.718  27.158   13 BB_U-22C-21:G-16A-15_BB B -22 ? B -15 ? B -21 ? B -16 ? 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Natural Science Foundation of China (NSFC)' China 82225028 1 
'National Natural Science Foundation of China (NSFC)' China 82172287 2 
# 
_atom_sites.entry_id                    8Y9L 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . HIS A 1 4   ? 107.232 82.900  117.734 1.00 58.68 ? 4   HIS A N     1 
ATOM   2    C  CA    . HIS A 1 4   ? 106.142 83.732  117.180 1.00 58.68 ? 4   HIS A CA    1 
ATOM   3    C  C     . HIS A 1 4   ? 105.478 84.375  118.398 1.00 58.68 ? 4   HIS A C     1 
ATOM   4    O  O     . HIS A 1 4   ? 104.342 83.986  118.738 1.00 58.68 ? 4   HIS A O     1 
ATOM   5    C  CB    . HIS A 1 4   ? 105.156 82.906  116.375 1.00 58.68 ? 4   HIS A CB    1 
ATOM   6    C  CG    . HIS A 1 4   ? 104.559 81.827  117.190 1.00 58.68 ? 4   HIS A CG    1 
ATOM   7    N  ND1   . HIS A 1 4   ? 103.441 81.142  116.824 1.00 58.68 ? 4   HIS A ND1   1 
ATOM   8    C  CD2   . HIS A 1 4   ? 104.903 81.363  118.399 1.00 58.68 ? 4   HIS A CD2   1 
ATOM   9    C  CE1   . HIS A 1 4   ? 103.142 80.260  117.758 1.00 58.68 ? 4   HIS A CE1   1 
ATOM   10   N  NE2   . HIS A 1 4   ? 104.022 80.373  118.727 1.00 58.68 ? 4   HIS A NE2   1 
ATOM   11   N  N     . GLU A 1 5   ? 106.257 85.231  119.086 1.00 59.26 ? 5   GLU A N     1 
ATOM   12   C  CA    . GLU A 1 5   ? 105.881 86.104  120.231 1.00 59.26 ? 5   GLU A CA    1 
ATOM   13   C  C     . GLU A 1 5   ? 106.407 87.481  119.840 1.00 59.26 ? 5   GLU A C     1 
ATOM   14   O  O     . GLU A 1 5   ? 107.599 87.563  119.650 1.00 59.26 ? 5   GLU A O     1 
ATOM   15   C  CB    . GLU A 1 5   ? 106.538 85.601  121.507 1.00 59.26 ? 5   GLU A CB    1 
ATOM   16   C  CG    . GLU A 1 5   ? 106.068 84.209  121.880 1.00 59.26 ? 5   GLU A CG    1 
ATOM   17   C  CD    . GLU A 1 5   ? 106.045 83.863  123.357 1.00 59.26 ? 5   GLU A CD    1 
ATOM   18   O  OE1   . GLU A 1 5   ? 105.023 83.341  123.842 1.00 59.26 ? 5   GLU A OE1   1 
ATOM   19   O  OE2   . GLU A 1 5   ? 107.055 84.118  124.009 1.00 59.26 ? 5   GLU A OE2   1 
ATOM   20   N  N     . ILE A 1 6   ? 105.544 88.474  119.644 1.00 39.71 ? 6   ILE A N     1 
ATOM   21   C  CA    . ILE A 1 6   ? 105.916 89.837  119.189 1.00 39.71 ? 6   ILE A CA    1 
ATOM   22   C  C     . ILE A 1 6   ? 106.107 90.675  120.436 1.00 39.71 ? 6   ILE A C     1 
ATOM   23   O  O     . ILE A 1 6   ? 105.165 90.620  121.132 1.00 39.71 ? 6   ILE A O     1 
ATOM   24   C  CB    . ILE A 1 6   ? 104.651 90.366  118.494 1.00 39.71 ? 6   ILE A CB    1 
ATOM   25   C  CG1   . ILE A 1 6   ? 104.293 89.651  117.199 1.00 39.71 ? 6   ILE A CG1   1 
ATOM   26   C  CG2   . ILE A 1 6   ? 104.677 91.843  118.248 1.00 39.71 ? 6   ILE A CG2   1 
ATOM   27   C  CD1   . ILE A 1 6   ? 103.574 90.563  116.229 1.00 39.71 ? 6   ILE A CD1   1 
ATOM   28   N  N     . PRO A 1 7   ? 107.260 91.301  120.809 1.00 33.65 ? 7   PRO A N     1 
ATOM   29   C  CA    . PRO A 1 7   ? 107.382 92.242  121.952 1.00 33.65 ? 7   PRO A CA    1 
ATOM   30   C  C     . PRO A 1 7   ? 106.701 93.615  121.945 1.00 33.65 ? 7   PRO A C     1 
ATOM   31   O  O     . PRO A 1 7   ? 106.778 94.245  121.004 1.00 33.65 ? 7   PRO A O     1 
ATOM   32   C  CB    . PRO A 1 7   ? 108.793 92.713  121.756 1.00 33.65 ? 7   PRO A CB    1 
ATOM   33   C  CG    . PRO A 1 7   ? 109.501 91.477  121.423 1.00 33.65 ? 7   PRO A CG    1 
ATOM   34   C  CD    . PRO A 1 7   ? 108.590 90.930  120.366 1.00 33.65 ? 7   PRO A CD    1 
ATOM   35   N  N     . ARG A 1 8   ? 106.035 94.027  123.018 1.00 29.66 ? 8   ARG A N     1 
ATOM   36   C  CA    . ARG A 1 8   ? 105.414 95.343  123.087 1.00 29.66 ? 8   ARG A CA    1 
ATOM   37   C  C     . ARG A 1 8   ? 105.439 95.792  124.543 1.00 29.66 ? 8   ARG A C     1 
ATOM   38   O  O     . ARG A 1 8   ? 105.679 94.989  125.448 1.00 29.66 ? 8   ARG A O     1 
ATOM   39   C  CB    . ARG A 1 8   ? 103.984 95.315  122.542 1.00 29.66 ? 8   ARG A CB    1 
ATOM   40   C  CG    . ARG A 1 8   ? 103.863 94.902  121.091 1.00 29.66 ? 8   ARG A CG    1 
ATOM   41   C  CD    . ARG A 1 8   ? 104.400 95.965  120.157 1.00 29.66 ? 8   ARG A CD    1 
ATOM   42   N  NE    . ARG A 1 8   ? 104.010 95.717  118.776 1.00 29.66 ? 8   ARG A NE    1 
ATOM   43   C  CZ    . ARG A 1 8   ? 104.810 95.203  117.854 1.00 29.66 ? 8   ARG A CZ    1 
ATOM   44   N  NH1   . ARG A 1 8   ? 106.063 94.885  118.126 1.00 29.66 ? 8   ARG A NH1   1 
ATOM   45   N  NH2   . ARG A 1 8   ? 104.340 95.005  116.627 1.00 29.66 ? 8   ARG A NH2   1 
ATOM   46   N  N     . SER A 1 9   ? 105.187 97.078  124.786 1.00 27.29 ? 9   SER A N     1 
ATOM   47   C  CA    . SER A 1 9   ? 105.251 97.592  126.149 1.00 27.29 ? 9   SER A CA    1 
ATOM   48   C  C     . SER A 1 9   ? 104.419 98.860  126.271 1.00 27.29 ? 9   SER A C     1 
ATOM   49   O  O     . SER A 1 9   ? 104.097 99.518  125.282 1.00 27.29 ? 9   SER A O     1 
ATOM   50   C  CB    . SER A 1 9   ? 106.696 97.858  126.574 1.00 27.29 ? 9   SER A CB    1 
ATOM   51   O  OG    . SER A 1 9   ? 106.753 98.315  127.913 1.00 27.29 ? 9   SER A OG    1 
ATOM   52   N  N     . GLN A 1 10  ? 104.082 99.195  127.514 1.00 26.06 ? 10  GLN A N     1 
ATOM   53   C  CA    . GLN A 1 10  ? 103.363 100.419 127.850 1.00 26.06 ? 10  GLN A CA    1 
ATOM   54   C  C     . GLN A 1 10  ? 103.508 100.639 129.351 1.00 26.06 ? 10  GLN A C     1 
ATOM   55   O  O     . GLN A 1 10  ? 104.032 99.787  130.072 1.00 26.06 ? 10  GLN A O     1 
ATOM   56   C  CB    . GLN A 1 10  ? 101.896 100.351 127.427 1.00 26.06 ? 10  GLN A CB    1 
ATOM   57   C  CG    . GLN A 1 10  ? 101.211 101.697 127.281 1.00 26.06 ? 10  GLN A CG    1 
ATOM   58   C  CD    . GLN A 1 10  ? 101.981 102.649 126.406 1.00 26.06 ? 10  GLN A CD    1 
ATOM   59   O  OE1   . GLN A 1 10  ? 102.237 103.789 126.783 1.00 26.06 ? 10  GLN A OE1   1 
ATOM   60   N  NE2   . GLN A 1 10  ? 102.369 102.183 125.233 1.00 26.06 ? 10  GLN A NE2   1 
ATOM   61   N  N     . LEU A 1 11  ? 103.029 101.792 129.815 1.00 21.72 ? 11  LEU A N     1 
ATOM   62   C  CA    . LEU A 1 11  ? 103.376 102.319 131.124 1.00 21.72 ? 11  LEU A CA    1 
ATOM   63   C  C     . LEU A 1 11  ? 102.146 102.497 132.006 1.00 21.72 ? 11  LEU A C     1 
ATOM   64   O  O     . LEU A 1 11  ? 101.040 102.755 131.529 1.00 21.72 ? 11  LEU A O     1 
ATOM   65   C  CB    . LEU A 1 11  ? 104.089 103.668 130.985 1.00 21.72 ? 11  LEU A CB    1 
ATOM   66   C  CG    . LEU A 1 11  ? 105.450 103.689 130.293 1.00 21.72 ? 11  LEU A CG    1 
ATOM   67   C  CD1   . LEU A 1 11  ? 105.911 105.123 130.128 1.00 21.72 ? 11  LEU A CD1   1 
ATOM   68   C  CD2   . LEU A 1 11  ? 106.464 102.884 131.069 1.00 21.72 ? 11  LEU A CD2   1 
ATOM   69   N  N     . LEU A 1 12  ? 102.366 102.359 133.314 1.00 22.07 ? 12  LEU A N     1 
ATOM   70   C  CA    . LEU A 1 12  ? 101.404 102.735 134.342 1.00 22.07 ? 12  LEU A CA    1 
ATOM   71   C  C     . LEU A 1 12  ? 102.071 103.708 135.303 1.00 22.07 ? 12  LEU A C     1 
ATOM   72   O  O     . LEU A 1 12  ? 103.264 103.590 135.596 1.00 22.07 ? 12  LEU A O     1 
ATOM   73   C  CB    . LEU A 1 12  ? 100.885 101.524 135.132 1.00 22.07 ? 12  LEU A CB    1 
ATOM   74   C  CG    . LEU A 1 12  ? 99.990  100.490 134.454 1.00 22.07 ? 12  LEU A CG    1 
ATOM   75   C  CD1   . LEU A 1 12  ? 99.895  99.251  135.313 1.00 22.07 ? 12  LEU A CD1   1 
ATOM   76   C  CD2   . LEU A 1 12  ? 98.619  101.068 134.221 1.00 22.07 ? 12  LEU A CD2   1 
ATOM   77   N  N     . LYS A 1 13  ? 101.295 104.664 135.805 1.00 24.57 ? 13  LYS A N     1 
ATOM   78   C  CA    . LYS A 1 13  ? 101.816 105.707 136.678 1.00 24.57 ? 13  LYS A CA    1 
ATOM   79   C  C     . LYS A 1 13  ? 101.793 105.235 138.124 1.00 24.57 ? 13  LYS A C     1 
ATOM   80   O  O     . LYS A 1 13  ? 100.804 104.651 138.577 1.00 24.57 ? 13  LYS A O     1 
ATOM   81   C  CB    . LYS A 1 13  ? 101.017 107.001 136.532 1.00 24.57 ? 13  LYS A CB    1 
ATOM   82   C  CG    . LYS A 1 13  ? 101.514 108.124 137.416 1.00 24.57 ? 13  LYS A CG    1 
ATOM   83   C  CD    . LYS A 1 13  ? 100.629 109.342 137.315 1.00 24.57 ? 13  LYS A CD    1 
ATOM   84   C  CE    . LYS A 1 13  ? 101.090 110.254 136.199 1.00 24.57 ? 13  LYS A CE    1 
ATOM   85   N  NZ    . LYS A 1 13  ? 100.511 111.618 136.318 1.00 24.57 ? 13  LYS A NZ    1 
ATOM   86   N  N     . ILE A 1 14  ? 102.885 105.488 138.841 1.00 26.25 ? 14  ILE A N     1 
ATOM   87   C  CA    . ILE A 1 14  ? 103.022 105.065 140.230 1.00 26.25 ? 14  ILE A CA    1 
ATOM   88   C  C     . ILE A 1 14  ? 102.553 106.189 141.143 1.00 26.25 ? 14  ILE A C     1 
ATOM   89   O  O     . ILE A 1 14  ? 103.116 107.289 141.129 1.00 26.25 ? 14  ILE A O     1 
ATOM   90   C  CB    . ILE A 1 14  ? 104.476 104.676 140.531 1.00 26.25 ? 14  ILE A CB    1 
ATOM   91   C  CG1   . ILE A 1 14  ? 104.895 103.501 139.651 1.00 26.25 ? 14  ILE A CG1   1 
ATOM   92   C  CG2   . ILE A 1 14  ? 104.645 104.333 141.994 1.00 26.25 ? 14  ILE A CG2   1 
ATOM   93   C  CD1   . ILE A 1 14  ? 106.372 103.278 139.600 1.00 26.25 ? 14  ILE A CD1   1 
ATOM   94   N  N     . LYS A 1 15  ? 101.528 105.912 141.949 1.00 31.49 ? 15  LYS A N     1 
ATOM   95   C  CA    . LYS A 1 15  ? 100.926 106.910 142.824 1.00 31.49 ? 15  LYS A CA    1 
ATOM   96   C  C     . LYS A 1 15  ? 101.645 107.040 144.160 1.00 31.49 ? 15  LYS A C     1 
ATOM   97   O  O     . LYS A 1 15  ? 102.027 108.144 144.555 1.00 31.49 ? 15  LYS A O     1 
ATOM   98   C  CB    . LYS A 1 15  ? 99.452  106.578 143.084 1.00 31.49 ? 15  LYS A CB    1 
ATOM   99   C  CG    . LYS A 1 15  ? 98.529  106.749 141.901 1.00 31.49 ? 15  LYS A CG    1 
ATOM   100  C  CD    . LYS A 1 15  ? 97.079  106.685 142.358 1.00 31.49 ? 15  LYS A CD    1 
ATOM   101  C  CE    . LYS A 1 15  ? 96.727  105.297 142.868 1.00 31.49 ? 15  LYS A CE    1 
ATOM   102  N  NZ    . LYS A 1 15  ? 95.295  105.170 143.246 1.00 31.49 ? 15  LYS A NZ    1 
ATOM   103  N  N     . GLN A 1 16  ? 101.823 105.931 144.870 1.00 41.15 ? 16  GLN A N     1 
ATOM   104  C  CA    . GLN A 1 16  ? 102.353 105.935 146.223 1.00 41.15 ? 16  GLN A CA    1 
ATOM   105  C  C     . GLN A 1 16  ? 103.522 104.964 146.307 1.00 41.15 ? 16  GLN A C     1 
ATOM   106  O  O     . GLN A 1 16  ? 103.830 104.239 145.358 1.00 41.15 ? 16  GLN A O     1 
ATOM   107  C  CB    . GLN A 1 16  ? 101.266 105.565 147.239 1.00 41.15 ? 16  GLN A CB    1 
ATOM   108  C  CG    . GLN A 1 16  ? 99.958  106.312 147.057 1.00 41.15 ? 16  GLN A CG    1 
ATOM   109  C  CD    . GLN A 1 16  ? 99.904  107.600 147.849 1.00 41.15 ? 16  GLN A CD    1 
ATOM   110  O  OE1   . GLN A 1 16  ? 100.880 108.347 147.910 1.00 41.15 ? 16  GLN A OE1   1 
ATOM   111  N  NE2   . GLN A 1 16  ? 98.759  107.868 148.463 1.00 41.15 ? 16  GLN A NE2   1 
ATOM   112  N  N     . TYR A 1 17  ? 104.182 104.957 147.461 1.00 45.96 ? 17  TYR A N     1 
ATOM   113  C  CA    . TYR A 1 17  ? 105.273 104.027 147.705 1.00 45.96 ? 17  TYR A CA    1 
ATOM   114  C  C     . TYR A 1 17  ? 105.404 103.792 149.202 1.00 45.96 ? 17  TYR A C     1 
ATOM   115  O  O     . TYR A 1 17  ? 104.946 104.593 150.020 1.00 45.96 ? 17  TYR A O     1 
ATOM   116  C  CB    . TYR A 1 17  ? 106.588 104.532 147.100 1.00 45.96 ? 17  TYR A CB    1 
ATOM   117  C  CG    . TYR A 1 17  ? 107.099 105.826 147.691 1.00 45.96 ? 17  TYR A CG    1 
ATOM   118  C  CD1   . TYR A 1 17  ? 106.726 107.050 147.151 1.00 45.96 ? 17  TYR A CD1   1 
ATOM   119  C  CD2   . TYR A 1 17  ? 107.946 105.829 148.792 1.00 45.96 ? 17  TYR A CD2   1 
ATOM   120  C  CE1   . TYR A 1 17  ? 107.189 108.236 147.680 1.00 45.96 ? 17  TYR A CE1   1 
ATOM   121  C  CE2   . TYR A 1 17  ? 108.408 107.012 149.335 1.00 45.96 ? 17  TYR A CE2   1 
ATOM   122  C  CZ    . TYR A 1 17  ? 108.029 108.212 148.772 1.00 45.96 ? 17  TYR A CZ    1 
ATOM   123  O  OH    . TYR A 1 17  ? 108.490 109.392 149.307 1.00 45.96 ? 17  TYR A OH    1 
ATOM   124  N  N     . GLU A 1 18  ? 106.036 102.671 149.544 1.00 48.65 ? 18  GLU A N     1 
ATOM   125  C  CA    . GLU A 1 18  ? 106.210 102.248 150.925 1.00 48.65 ? 18  GLU A CA    1 
ATOM   126  C  C     . GLU A 1 18  ? 107.595 101.644 151.089 1.00 48.65 ? 18  GLU A C     1 
ATOM   127  O  O     . GLU A 1 18  ? 108.266 101.307 150.112 1.00 48.65 ? 18  GLU A O     1 
ATOM   128  C  CB    . GLU A 1 18  ? 105.149 101.222 151.344 1.00 48.65 ? 18  GLU A CB    1 
ATOM   129  C  CG    . GLU A 1 18  ? 103.821 101.817 151.760 1.00 48.65 ? 18  GLU A CG    1 
ATOM   130  C  CD    . GLU A 1 18  ? 102.942 100.811 152.477 1.00 48.65 ? 18  GLU A CD    1 
ATOM   131  O  OE1   . GLU A 1 18  ? 103.435 99.706  152.783 1.00 48.65 ? 18  GLU A OE1   1 
ATOM   132  O  OE2   . GLU A 1 18  ? 101.762 101.124 152.735 1.00 48.65 ? 18  GLU A OE2   1 
ATOM   133  N  N     . GLY A 1 19  ? 108.017 101.509 152.342 1.00 48.87 ? 19  GLY A N     1 
ATOM   134  C  CA    . GLY A 1 19  ? 109.291 100.885 152.630 1.00 48.87 ? 19  GLY A CA    1 
ATOM   135  C  C     . GLY A 1 19  ? 110.466 101.756 152.218 1.00 48.87 ? 19  GLY A C     1 
ATOM   136  O  O     . GLY A 1 19  ? 110.374 102.976 152.090 1.00 48.87 ? 19  GLY A O     1 
ATOM   137  N  N     . SER A 1 20  ? 111.601 101.090 152.014 1.00 47.44 ? 20  SER A N     1 
ATOM   138  C  CA    . SER A 1 20  ? 112.823 101.765 151.583 1.00 47.44 ? 20  SER A CA    1 
ATOM   139  C  C     . SER A 1 20  ? 112.955 101.703 150.060 1.00 47.44 ? 20  SER A C     1 
ATOM   140  O  O     . SER A 1 20  ? 113.875 101.105 149.505 1.00 47.44 ? 20  SER A O     1 
ATOM   141  C  CB    . SER A 1 20  ? 114.035 101.149 152.267 1.00 47.44 ? 20  SER A CB    1 
ATOM   142  O  OG    . SER A 1 20  ? 114.374 99.907  151.676 1.00 47.44 ? 20  SER A OG    1 
ATOM   143  N  N     . PHE A 1 21  ? 112.006 102.348 149.383 1.00 40.53 ? 21  PHE A N     1 
ATOM   144  C  CA    . PHE A 1 21  ? 111.965 102.313 147.927 1.00 40.53 ? 21  PHE A CA    1 
ATOM   145  C  C     . PHE A 1 21  ? 112.831 103.400 147.300 1.00 40.53 ? 21  PHE A C     1 
ATOM   146  O  O     . PHE A 1 21  ? 113.630 103.118 146.400 1.00 40.53 ? 21  PHE A O     1 
ATOM   147  C  CB    . PHE A 1 21  ? 110.518 102.442 147.440 1.00 40.53 ? 21  PHE A CB    1 
ATOM   148  C  CG    . PHE A 1 21  ? 110.397 102.854 146.002 1.00 40.53 ? 21  PHE A CG    1 
ATOM   149  C  CD1   . PHE A 1 21  ? 110.696 101.963 144.986 1.00 40.53 ? 21  PHE A CD1   1 
ATOM   150  C  CD2   . PHE A 1 21  ? 109.984 104.131 145.665 1.00 40.53 ? 21  PHE A CD2   1 
ATOM   151  C  CE1   . PHE A 1 21  ? 110.588 102.337 143.665 1.00 40.53 ? 21  PHE A CE1   1 
ATOM   152  C  CE2   . PHE A 1 21  ? 109.875 104.509 144.344 1.00 40.53 ? 21  PHE A CE2   1 
ATOM   153  C  CZ    . PHE A 1 21  ? 110.177 103.611 143.344 1.00 40.53 ? 21  PHE A CZ    1 
ATOM   154  N  N     . VAL A 1 22  ? 112.686 104.644 147.763 1.00 40.32 ? 22  VAL A N     1 
ATOM   155  C  CA    . VAL A 1 22  ? 113.403 105.756 147.142 1.00 40.32 ? 22  VAL A CA    1 
ATOM   156  C  C     . VAL A 1 22  ? 114.905 105.613 147.351 1.00 40.32 ? 22  VAL A C     1 
ATOM   157  O  O     . VAL A 1 22  ? 115.701 105.955 146.470 1.00 40.32 ? 22  VAL A O     1 
ATOM   158  C  CB    . VAL A 1 22  ? 112.879 107.098 147.679 1.00 40.32 ? 22  VAL A CB    1 
ATOM   159  C  CG1   . VAL A 1 22  ? 113.451 108.244 146.871 1.00 40.32 ? 22  VAL A CG1   1 
ATOM   160  C  CG2   . VAL A 1 22  ? 111.375 107.121 147.617 1.00 40.32 ? 22  VAL A CG2   1 
ATOM   161  N  N     . GLU A 1 23  ? 115.319 105.114 148.517 1.00 43.56 ? 23  GLU A N     1 
ATOM   162  C  CA    . GLU A 1 23  ? 116.736 104.848 148.737 1.00 43.56 ? 23  GLU A CA    1 
ATOM   163  C  C     . GLU A 1 23  ? 117.255 103.815 147.747 1.00 43.56 ? 23  GLU A C     1 
ATOM   164  O  O     . GLU A 1 23  ? 118.344 103.974 147.183 1.00 43.56 ? 23  GLU A O     1 
ATOM   165  C  CB    . GLU A 1 23  ? 116.967 104.373 150.171 1.00 43.56 ? 23  GLU A CB    1 
ATOM   166  C  CG    . GLU A 1 23  ? 116.508 105.349 151.240 1.00 43.56 ? 23  GLU A CG    1 
ATOM   167  C  CD    . GLU A 1 23  ? 116.692 106.794 150.830 1.00 43.56 ? 23  GLU A CD    1 
ATOM   168  O  OE1   . GLU A 1 23  ? 117.852 107.246 150.742 1.00 43.56 ? 23  GLU A OE1   1 
ATOM   169  O  OE2   . GLU A 1 23  ? 115.676 107.480 150.596 1.00 43.56 ? 23  GLU A OE2   1 
ATOM   170  N  N     . TRP A 1 24  ? 116.479 102.755 147.519 1.00 39.64 ? 24  TRP A N     1 
ATOM   171  C  CA    . TRP A 1 24  ? 116.843 101.730 146.546 1.00 39.64 ? 24  TRP A CA    1 
ATOM   172  C  C     . TRP A 1 24  ? 117.022 102.333 145.157 1.00 39.64 ? 24  TRP A C     1 
ATOM   173  O  O     . TRP A 1 24  ? 118.051 102.127 144.498 1.00 39.64 ? 24  TRP A O     1 
ATOM   174  C  CB    . TRP A 1 24  ? 115.758 100.651 146.549 1.00 39.64 ? 24  TRP A CB    1 
ATOM   175  C  CG    . TRP A 1 24  ? 115.883 99.565  145.530 1.00 39.64 ? 24  TRP A CG    1 
ATOM   176  C  CD1   . TRP A 1 24  ? 116.741 98.505  145.555 1.00 39.64 ? 24  TRP A CD1   1 
ATOM   177  C  CD2   . TRP A 1 24  ? 115.095 99.415  144.345 1.00 39.64 ? 24  TRP A CD2   1 
ATOM   178  N  NE1   . TRP A 1 24  ? 116.544 97.710  144.453 1.00 39.64 ? 24  TRP A NE1   1 
ATOM   179  C  CE2   . TRP A 1 24  ? 115.539 98.248  143.693 1.00 39.64 ? 24  TRP A CE2   1 
ATOM   180  C  CE3   . TRP A 1 24  ? 114.062 100.159 143.767 1.00 39.64 ? 24  TRP A CE3   1 
ATOM   181  C  CZ2   . TRP A 1 24  ? 114.987 97.810  142.495 1.00 39.64 ? 24  TRP A CZ2   1 
ATOM   182  C  CZ3   . TRP A 1 24  ? 113.517 99.723  142.578 1.00 39.64 ? 24  TRP A CZ3   1 
ATOM   183  C  CH2   . TRP A 1 24  ? 113.979 98.559  141.954 1.00 39.64 ? 24  TRP A CH2   1 
ATOM   184  N  N     . TYR A 1 25  ? 116.032 103.109 144.710 1.00 34.25 ? 25  TYR A N     1 
ATOM   185  C  CA    . TYR A 1 25  ? 116.087 103.698 143.377 1.00 34.25 ? 25  TYR A CA    1 
ATOM   186  C  C     . TYR A 1 25  ? 117.265 104.657 143.235 1.00 34.25 ? 25  TYR A C     1 
ATOM   187  O  O     . TYR A 1 25  ? 117.990 104.623 142.230 1.00 34.25 ? 25  TYR A O     1 
ATOM   188  C  CB    . TYR A 1 25  ? 114.773 104.415 143.083 1.00 34.25 ? 25  TYR A CB    1 
ATOM   189  C  CG    . TYR A 1 25  ? 114.665 104.949 141.681 1.00 34.25 ? 25  TYR A CG    1 
ATOM   190  C  CD1   . TYR A 1 25  ? 114.556 104.092 140.600 1.00 34.25 ? 25  TYR A CD1   1 
ATOM   191  C  CD2   . TYR A 1 25  ? 114.670 106.312 141.438 1.00 34.25 ? 25  TYR A CD2   1 
ATOM   192  C  CE1   . TYR A 1 25  ? 114.457 104.576 139.319 1.00 34.25 ? 25  TYR A CE1   1 
ATOM   193  C  CE2   . TYR A 1 25  ? 114.571 106.805 140.160 1.00 34.25 ? 25  TYR A CE2   1 
ATOM   194  C  CZ    . TYR A 1 25  ? 114.465 105.933 139.104 1.00 34.25 ? 25  TYR A CZ    1 
ATOM   195  O  OH    . TYR A 1 25  ? 114.367 106.421 137.824 1.00 34.25 ? 25  TYR A OH    1 
ATOM   196  N  N     . ARG A 1 26  ? 117.475 105.518 144.235 1.00 40.08 ? 26  ARG A N     1 
ATOM   197  C  CA    . ARG A 1 26  ? 118.554 106.497 144.170 1.00 40.08 ? 26  ARG A CA    1 
ATOM   198  C  C     . ARG A 1 26  ? 119.919 105.824 144.169 1.00 40.08 ? 26  ARG A C     1 
ATOM   199  O  O     . ARG A 1 26  ? 120.812 106.228 143.416 1.00 40.08 ? 26  ARG A O     1 
ATOM   200  C  CB    . ARG A 1 26  ? 118.437 107.472 145.338 1.00 40.08 ? 26  ARG A CB    1 
ATOM   201  C  CG    . ARG A 1 26  ? 119.423 108.619 145.302 1.00 40.08 ? 26  ARG A CG    1 
ATOM   202  C  CD    . ARG A 1 26  ? 119.221 109.521 146.504 1.00 40.08 ? 26  ARG A CD    1 
ATOM   203  N  NE    . ARG A 1 26  ? 119.560 108.832 147.744 1.00 40.08 ? 26  ARG A NE    1 
ATOM   204  C  CZ    . ARG A 1 26  ? 119.289 109.293 148.956 1.00 40.08 ? 26  ARG A CZ    1 
ATOM   205  N  NH1   . ARG A 1 26  ? 118.659 110.443 149.134 1.00 40.08 ? 26  ARG A NH1   1 
ATOM   206  N  NH2   . ARG A 1 26  ? 119.654 108.580 150.018 1.00 40.08 ? 26  ARG A NH2   1 
ATOM   207  N  N     . ASP A 1 27  ? 120.106 104.800 145.004 1.00 39.36 ? 27  ASP A N     1 
ATOM   208  C  CA    . ASP A 1 27  ? 121.375 104.086 145.007 1.00 39.36 ? 27  ASP A CA    1 
ATOM   209  C  C     . ASP A 1 27  ? 121.634 103.423 143.663 1.00 39.36 ? 27  ASP A C     1 
ATOM   210  O  O     . ASP A 1 27  ? 122.752 103.491 143.133 1.00 39.36 ? 27  ASP A O     1 
ATOM   211  C  CB    . ASP A 1 27  ? 121.391 103.046 146.126 1.00 39.36 ? 27  ASP A CB    1 
ATOM   212  C  CG    . ASP A 1 27  ? 121.372 103.671 147.503 1.00 39.36 ? 27  ASP A CG    1 
ATOM   213  O  OD1   . ASP A 1 27  ? 121.861 104.809 147.650 1.00 39.36 ? 27  ASP A OD1   1 
ATOM   214  O  OD2   . ASP A 1 27  ? 120.867 103.022 148.441 1.00 39.36 ? 27  ASP A OD2   1 
ATOM   215  N  N     . LEU A 1 28  ? 120.613 102.773 143.094 1.00 36.83 ? 28  LEU A N     1 
ATOM   216  C  CA    . LEU A 1 28  ? 120.802 102.127 141.800 1.00 36.83 ? 28  LEU A CA    1 
ATOM   217  C  C     . LEU A 1 28  ? 121.194 103.141 140.734 1.00 36.83 ? 28  LEU A C     1 
ATOM   218  O  O     . LEU A 1 28  ? 122.130 102.908 139.959 1.00 36.83 ? 28  LEU A O     1 
ATOM   219  C  CB    . LEU A 1 28  ? 119.533 101.384 141.387 1.00 36.83 ? 28  LEU A CB    1 
ATOM   220  C  CG    . LEU A 1 28  ? 119.462 99.905  141.764 1.00 36.83 ? 28  LEU A CG    1 
ATOM   221  C  CD1   . LEU A 1 28  ? 118.157 99.299  141.297 1.00 36.83 ? 28  LEU A CD1   1 
ATOM   222  C  CD2   . LEU A 1 28  ? 120.636 99.152  141.183 1.00 36.83 ? 28  LEU A CD2   1 
ATOM   223  N  N     . GLN A 1 29  ? 120.507 104.284 140.696 1.00 34.10 ? 29  GLN A N     1 
ATOM   224  C  CA    . GLN A 1 29  ? 120.796 105.268 139.658 1.00 34.10 ? 29  GLN A CA    1 
ATOM   225  C  C     . GLN A 1 29  ? 122.175 105.896 139.841 1.00 34.10 ? 29  GLN A C     1 
ATOM   226  O  O     . GLN A 1 29  ? 122.896 106.112 138.858 1.00 34.10 ? 29  GLN A O     1 
ATOM   227  C  CB    . GLN A 1 29  ? 119.706 106.330 139.635 1.00 34.10 ? 29  GLN A CB    1 
ATOM   228  C  CG    . GLN A 1 29  ? 118.365 105.773 139.215 1.00 34.10 ? 29  GLN A CG    1 
ATOM   229  C  CD    . GLN A 1 29  ? 118.315 105.424 137.744 1.00 34.10 ? 29  GLN A CD    1 
ATOM   230  O  OE1   . GLN A 1 29  ? 119.084 105.949 136.945 1.00 34.10 ? 29  GLN A OE1   1 
ATOM   231  N  NE2   . GLN A 1 29  ? 117.413 104.524 137.380 1.00 34.10 ? 29  GLN A NE2   1 
ATOM   232  N  N     . GLU A 1 30  ? 122.567 106.192 141.084 1.00 37.50 ? 30  GLU A N     1 
ATOM   233  C  CA    . GLU A 1 30  ? 123.890 106.768 141.315 1.00 37.50 ? 30  GLU A CA    1 
ATOM   234  C  C     . GLU A 1 30  ? 124.998 105.799 140.925 1.00 37.50 ? 30  GLU A C     1 
ATOM   235  O  O     . GLU A 1 30  ? 125.975 106.196 140.277 1.00 37.50 ? 30  GLU A O     1 
ATOM   236  C  CB    . GLU A 1 30  ? 124.041 107.187 142.776 1.00 37.50 ? 30  GLU A CB    1 
ATOM   237  C  CG    . GLU A 1 30  ? 123.206 108.391 143.154 1.00 37.50 ? 30  GLU A CG    1 
ATOM   238  C  CD    . GLU A 1 30  ? 123.636 109.642 142.419 1.00 37.50 ? 30  GLU A CD    1 
ATOM   239  O  OE1   . GLU A 1 30  ? 124.847 109.786 142.153 1.00 37.50 ? 30  GLU A OE1   1 
ATOM   240  O  OE2   . GLU A 1 30  ? 122.765 110.478 142.100 1.00 37.50 ? 30  GLU A OE2   1 
ATOM   241  N  N     . ASP A 1 31  ? 124.870 104.525 141.304 1.00 39.35 ? 31  ASP A N     1 
ATOM   242  C  CA    . ASP A 1 31  ? 125.888 103.557 140.911 1.00 39.35 ? 31  ASP A CA    1 
ATOM   243  C  C     . ASP A 1 31  ? 125.935 103.384 139.401 1.00 39.35 ? 31  ASP A C     1 
ATOM   244  O  O     . ASP A 1 31  ? 127.020 103.243 138.823 1.00 39.35 ? 31  ASP A O     1 
ATOM   245  C  CB    . ASP A 1 31  ? 125.651 102.218 141.601 1.00 39.35 ? 31  ASP A CB    1 
ATOM   246  C  CG    . ASP A 1 31  ? 125.906 102.282 143.085 1.00 39.35 ? 31  ASP A CG    1 
ATOM   247  O  OD1   . ASP A 1 31  ? 126.748 103.102 143.506 1.00 39.35 ? 31  ASP A OD1   1 
ATOM   248  O  OD2   . ASP A 1 31  ? 125.275 101.509 143.833 1.00 39.35 ? 31  ASP A OD2   1 
ATOM   249  N  N     . ARG A 1 32  ? 124.774 103.389 138.739 1.00 35.91 ? 32  ARG A N     1 
ATOM   250  C  CA    . ARG A 1 32  ? 124.774 103.296 137.284 1.00 35.91 ? 32  ARG A CA    1 
ATOM   251  C  C     . ARG A 1 32  ? 125.513 104.470 136.661 1.00 35.91 ? 32  ARG A C     1 
ATOM   252  O  O     . ARG A 1 32  ? 126.344 104.285 135.765 1.00 35.91 ? 32  ARG A O     1 
ATOM   253  C  CB    . ARG A 1 32  ? 123.344 103.229 136.752 1.00 35.91 ? 32  ARG A CB    1 
ATOM   254  C  CG    . ARG A 1 32  ? 123.238 103.498 135.263 1.00 35.91 ? 32  ARG A CG    1 
ATOM   255  C  CD    . ARG A 1 32  ? 121.896 104.084 134.905 1.00 35.91 ? 32  ARG A CD    1 
ATOM   256  N  NE    . ARG A 1 32  ? 121.813 105.508 135.196 1.00 35.91 ? 32  ARG A NE    1 
ATOM   257  C  CZ    . ARG A 1 32  ? 122.142 106.465 134.341 1.00 35.91 ? 32  ARG A CZ    1 
ATOM   258  N  NH1   . ARG A 1 32  ? 122.598 106.184 133.134 1.00 35.91 ? 32  ARG A NH1   1 
ATOM   259  N  NH2   . ARG A 1 32  ? 122.001 107.735 134.704 1.00 35.91 ? 32  ARG A NH2   1 
ATOM   260  N  N     . LYS A 1 33  ? 125.235 105.687 137.134 1.00 38.43 ? 33  LYS A N     1 
ATOM   261  C  CA    . LYS A 1 33  ? 125.899 106.865 136.581 1.00 38.43 ? 33  LYS A CA    1 
ATOM   262  C  C     . LYS A 1 33  ? 127.404 106.800 136.800 1.00 38.43 ? 33  LYS A C     1 
ATOM   263  O  O     . LYS A 1 33  ? 128.190 107.150 135.913 1.00 38.43 ? 33  LYS A O     1 
ATOM   264  C  CB    . LYS A 1 33  ? 125.322 108.134 137.205 1.00 38.43 ? 33  LYS A CB    1 
ATOM   265  C  CG    . LYS A 1 33  ? 125.968 109.412 136.713 1.00 38.43 ? 33  LYS A CG    1 
ATOM   266  C  CD    . LYS A 1 33  ? 125.278 110.635 137.293 1.00 38.43 ? 33  LYS A CD    1 
ATOM   267  C  CE    . LYS A 1 33  ? 125.615 110.813 138.761 1.00 38.43 ? 33  LYS A CE    1 
ATOM   268  N  NZ    . LYS A 1 33  ? 125.040 112.069 139.310 1.00 38.43 ? 33  LYS A NZ    1 
ATOM   269  N  N     . LYS A 1 34  ? 127.827 106.356 137.984 1.00 41.08 ? 34  LYS A N     1 
ATOM   270  C  CA    . LYS A 1 34  ? 129.256 106.292 138.271 1.00 41.08 ? 34  LYS A CA    1 
ATOM   271  C  C     . LYS A 1 34  ? 129.957 105.241 137.417 1.00 41.08 ? 34  LYS A C     1 
ATOM   272  O  O     . LYS A 1 34  ? 131.058 105.483 136.910 1.00 41.08 ? 34  LYS A O     1 
ATOM   273  C  CB    . LYS A 1 34  ? 129.485 106.012 139.755 1.00 41.08 ? 34  LYS A CB    1 
ATOM   274  C  CG    . LYS A 1 34  ? 130.895 105.571 140.085 1.00 41.08 ? 34  LYS A CG    1 
ATOM   275  C  CD    . LYS A 1 34  ? 131.067 105.345 141.572 1.00 41.08 ? 34  LYS A CD    1 
ATOM   276  C  CE    . LYS A 1 34  ? 132.508 105.013 141.913 1.00 41.08 ? 34  LYS A CE    1 
ATOM   277  N  NZ    . LYS A 1 34  ? 132.693 104.812 143.375 1.00 41.08 ? 34  LYS A NZ    1 
ATOM   278  N  N     . PHE A 1 35  ? 129.344 104.070 137.241 1.00 42.75 ? 35  PHE A N     1 
ATOM   279  C  CA    . PHE A 1 35  ? 130.056 102.951 136.638 1.00 42.75 ? 35  PHE A CA    1 
ATOM   280  C  C     . PHE A 1 35  ? 129.908 102.864 135.125 1.00 42.75 ? 35  PHE A C     1 
ATOM   281  O  O     . PHE A 1 35  ? 130.769 102.259 134.472 1.00 42.75 ? 35  PHE A O     1 
ATOM   282  C  CB    . PHE A 1 35  ? 129.608 101.639 137.281 1.00 42.75 ? 35  PHE A CB    1 
ATOM   283  C  CG    . PHE A 1 35  ? 130.286 101.360 138.586 1.00 42.75 ? 35  PHE A CG    1 
ATOM   284  C  CD1   . PHE A 1 35  ? 129.731 101.795 139.773 1.00 42.75 ? 35  PHE A CD1   1 
ATOM   285  C  CD2   . PHE A 1 35  ? 131.501 100.703 138.622 1.00 42.75 ? 35  PHE A CD2   1 
ATOM   286  C  CE1   . PHE A 1 35  ? 130.362 101.554 140.975 1.00 42.75 ? 35  PHE A CE1   1 
ATOM   287  C  CE2   . PHE A 1 35  ? 132.136 100.461 139.821 1.00 42.75 ? 35  PHE A CE2   1 
ATOM   288  C  CZ    . PHE A 1 35  ? 131.565 100.887 140.999 1.00 42.75 ? 35  PHE A CZ    1 
ATOM   289  N  N     . ALA A 1 36  ? 128.859 103.451 134.546 1.00 41.01 ? 36  ALA A N     1 
ATOM   290  C  CA    . ALA A 1 36  ? 128.773 103.502 133.093 1.00 41.01 ? 36  ALA A CA    1 
ATOM   291  C  C     . ALA A 1 36  ? 129.932 104.300 132.517 1.00 41.01 ? 36  ALA A C     1 
ATOM   292  O  O     . ALA A 1 36  ? 130.466 103.955 131.461 1.00 41.01 ? 36  ALA A O     1 
ATOM   293  C  CB    . ALA A 1 36  ? 127.434 104.095 132.657 1.00 41.01 ? 36  ALA A CB    1 
ATOM   294  N  N     . SER A 1 37  ? 130.351 105.361 133.213 1.00 41.76 ? 37  SER A N     1 
ATOM   295  C  CA    . SER A 1 37  ? 131.492 106.155 132.761 1.00 41.76 ? 37  SER A CA    1 
ATOM   296  C  C     . SER A 1 37  ? 132.750 105.306 132.648 1.00 41.76 ? 37  SER A C     1 
ATOM   297  O  O     . SER A 1 37  ? 133.427 105.307 131.614 1.00 41.76 ? 37  SER A O     1 
ATOM   298  C  CB    . SER A 1 37  ? 131.731 107.318 133.721 1.00 41.76 ? 37  SER A CB    1 
ATOM   299  O  OG    . SER A 1 37  ? 130.524 107.991 134.018 1.00 41.76 ? 37  SER A OG    1 
ATOM   300  N  N     . LEU A 1 38  ? 133.083 104.582 133.716 1.00 43.74 ? 38  LEU A N     1 
ATOM   301  C  CA    . LEU A 1 38  ? 134.299 103.781 133.720 1.00 43.74 ? 38  LEU A CA    1 
ATOM   302  C  C     . LEU A 1 38  ? 134.225 102.663 132.689 1.00 43.74 ? 38  LEU A C     1 
ATOM   303  O  O     . LEU A 1 38  ? 135.167 102.462 131.910 1.00 43.74 ? 38  LEU A O     1 
ATOM   304  C  CB    . LEU A 1 38  ? 134.534 103.216 135.120 1.00 43.74 ? 38  LEU A CB    1 
ATOM   305  C  CG    . LEU A 1 38  ? 135.567 102.105 135.290 1.00 43.74 ? 38  LEU A CG    1 
ATOM   306  C  CD1   . LEU A 1 38  ? 136.967 102.690 135.346 1.00 43.74 ? 38  LEU A CD1   1 
ATOM   307  C  CD2   . LEU A 1 38  ? 135.275 101.286 136.534 1.00 43.74 ? 38  LEU A CD2   1 
ATOM   308  N  N     . LEU A 1 39  ? 133.103 101.940 132.647 1.00 44.16 ? 39  LEU A N     1 
ATOM   309  C  CA    . LEU A 1 39  ? 132.976 100.840 131.701 1.00 44.16 ? 39  LEU A CA    1 
ATOM   310  C  C     . LEU A 1 39  ? 132.829 101.318 130.262 1.00 44.16 ? 39  LEU A C     1 
ATOM   311  O  O     . LEU A 1 39  ? 132.992 100.516 129.337 1.00 44.16 ? 39  LEU A O     1 
ATOM   312  C  CB    . LEU A 1 39  ? 131.790 99.953  132.089 1.00 44.16 ? 39  LEU A CB    1 
ATOM   313  C  CG    . LEU A 1 39  ? 131.689 98.593  131.402 1.00 44.16 ? 39  LEU A CG    1 
ATOM   314  C  CD1   . LEU A 1 39  ? 132.877 97.761  131.784 1.00 44.16 ? 39  LEU A CD1   1 
ATOM   315  C  CD2   . LEU A 1 39  ? 130.423 97.882  131.796 1.00 44.16 ? 39  LEU A CD2   1 
ATOM   316  N  N     . PHE A 1 40  ? 132.535 102.602 130.048 1.00 43.43 ? 40  PHE A N     1 
ATOM   317  C  CA    . PHE A 1 40  ? 132.507 103.139 128.695 1.00 43.43 ? 40  PHE A CA    1 
ATOM   318  C  C     . PHE A 1 40  ? 133.891 103.584 128.256 1.00 43.43 ? 40  PHE A C     1 
ATOM   319  O  O     . PHE A 1 40  ? 134.312 103.299 127.131 1.00 43.43 ? 40  PHE A O     1 
ATOM   320  C  CB    . PHE A 1 40  ? 131.532 104.308 128.621 1.00 43.43 ? 40  PHE A CB    1 
ATOM   321  C  CG    . PHE A 1 40  ? 131.746 105.197 127.437 1.00 43.43 ? 40  PHE A CG    1 
ATOM   322  C  CD1   . PHE A 1 40  ? 131.543 104.724 126.157 1.00 43.43 ? 40  PHE A CD1   1 
ATOM   323  C  CD2   . PHE A 1 40  ? 132.172 106.498 127.604 1.00 43.43 ? 40  PHE A CD2   1 
ATOM   324  C  CE1   . PHE A 1 40  ? 131.737 105.542 125.070 1.00 43.43 ? 40  PHE A CE1   1 
ATOM   325  C  CE2   . PHE A 1 40  ? 132.372 107.317 126.519 1.00 43.43 ? 40  PHE A CE2   1 
ATOM   326  C  CZ    . PHE A 1 40  ? 132.156 106.838 125.249 1.00 43.43 ? 40  PHE A CZ    1 
ATOM   327  N  N     . ARG A 1 41  ? 134.613 104.289 129.124 1.00 47.69 ? 41  ARG A N     1 
ATOM   328  C  CA    . ARG A 1 41  ? 135.977 104.671 128.795 1.00 47.69 ? 41  ARG A CA    1 
ATOM   329  C  C     . ARG A 1 41  ? 136.912 103.473 128.736 1.00 47.69 ? 41  ARG A C     1 
ATOM   330  O  O     . ARG A 1 41  ? 138.009 103.594 128.183 1.00 47.69 ? 41  ARG A O     1 
ATOM   331  C  CB    . ARG A 1 41  ? 136.504 105.707 129.793 1.00 47.69 ? 41  ARG A CB    1 
ATOM   332  C  CG    . ARG A 1 41  ? 135.704 106.998 129.779 1.00 47.69 ? 41  ARG A CG    1 
ATOM   333  C  CD    . ARG A 1 41  ? 136.421 108.144 130.467 1.00 47.69 ? 41  ARG A CD    1 
ATOM   334  N  NE    . ARG A 1 41  ? 136.717 107.862 131.864 1.00 47.69 ? 41  ARG A NE    1 
ATOM   335  C  CZ    . ARG A 1 41  ? 137.929 107.938 132.395 1.00 47.69 ? 41  ARG A CZ    1 
ATOM   336  N  NH1   . ARG A 1 41  ? 138.967 108.347 131.686 1.00 47.69 ? 41  ARG A NH1   1 
ATOM   337  N  NH2   . ARG A 1 41  ? 138.100 107.611 133.673 1.00 47.69 ? 41  ARG A NH2   1 
ATOM   338  N  N     . TRP A 1 42  ? 136.506 102.325 129.286 1.00 49.91 ? 42  TRP A N     1 
ATOM   339  C  CA    . TRP A 1 42  ? 137.196 101.079 128.967 1.00 49.91 ? 42  TRP A CA    1 
ATOM   340  C  C     . TRP A 1 42  ? 137.104 100.785 127.476 1.00 49.91 ? 42  TRP A C     1 
ATOM   341  O  O     . TRP A 1 42  ? 138.073 100.332 126.857 1.00 49.91 ? 42  TRP A O     1 
ATOM   342  C  CB    . TRP A 1 42  ? 136.610 99.916  129.767 1.00 49.91 ? 42  TRP A CB    1 
ATOM   343  C  CG    . TRP A 1 42  ? 137.015 99.874  131.202 1.00 49.91 ? 42  TRP A CG    1 
ATOM   344  C  CD1   . TRP A 1 42  ? 137.659 100.849 131.902 1.00 49.91 ? 42  TRP A CD1   1 
ATOM   345  C  CD2   . TRP A 1 42  ? 136.825 98.785  132.113 1.00 49.91 ? 42  TRP A CD2   1 
ATOM   346  N  NE1   . TRP A 1 42  ? 137.869 100.440 133.197 1.00 49.91 ? 42  TRP A NE1   1 
ATOM   347  C  CE2   . TRP A 1 42  ? 137.367 99.175  133.350 1.00 49.91 ? 42  TRP A CE2   1 
ATOM   348  C  CE3   . TRP A 1 42  ? 136.249 97.519  132.001 1.00 49.91 ? 42  TRP A CE3   1 
ATOM   349  C  CZ2   . TRP A 1 42  ? 137.346 98.347  134.467 1.00 49.91 ? 42  TRP A CZ2   1 
ATOM   350  C  CZ3   . TRP A 1 42  ? 136.225 96.701  133.111 1.00 49.91 ? 42  TRP A CZ3   1 
ATOM   351  C  CH2   . TRP A 1 42  ? 136.772 97.116  134.327 1.00 49.91 ? 42  TRP A CH2   1 
ATOM   352  N  N     . ALA A 1 43  ? 135.936 101.025 126.883 1.00 47.74 ? 43  ALA A N     1 
ATOM   353  C  CA    . ALA A 1 43  ? 135.743 100.846 125.449 1.00 47.74 ? 43  ALA A CA    1 
ATOM   354  C  C     . ALA A 1 43  ? 136.389 102.012 124.717 1.00 47.74 ? 43  ALA A C     1 
ATOM   355  O  O     . ALA A 1 43  ? 136.089 103.175 125.001 1.00 47.74 ? 43  ALA A O     1 
ATOM   356  C  CB    . ALA A 1 43  ? 134.258 100.758 125.111 1.00 47.74 ? 43  ALA A CB    1 
ATOM   357  N  N     . ALA A 1 44  ? 137.268 101.711 123.766 1.00 50.43 ? 44  ALA A N     1 
ATOM   358  C  CA    . ALA A 1 44  ? 137.856 102.773 122.966 1.00 50.43 ? 44  ALA A CA    1 
ATOM   359  C  C     . ALA A 1 44  ? 136.807 103.306 122.002 1.00 50.43 ? 44  ALA A C     1 
ATOM   360  O  O     . ALA A 1 44  ? 136.637 102.774 120.901 1.00 50.43 ? 44  ALA A O     1 
ATOM   361  C  CB    . ALA A 1 44  ? 139.087 102.271 122.211 1.00 50.43 ? 44  ALA A CB    1 
ATOM   362  N  N     . PHE A 1 45  ? 136.090 104.345 122.413 1.00 43.53 ? 45  PHE A N     1 
ATOM   363  C  CA    . PHE A 1 45  ? 135.048 104.950 121.601 1.00 43.53 ? 45  PHE A CA    1 
ATOM   364  C  C     . PHE A 1 45  ? 135.401 106.398 121.309 1.00 43.53 ? 45  PHE A C     1 
ATOM   365  O  O     . PHE A 1 45  ? 135.717 107.164 122.222 1.00 43.53 ? 45  PHE A O     1 
ATOM   366  C  CB    . PHE A 1 45  ? 133.689 104.894 122.302 1.00 43.53 ? 45  PHE A CB    1 
ATOM   367  C  CG    . PHE A 1 45  ? 132.929 103.621 122.066 1.00 43.53 ? 45  PHE A CG    1 
ATOM   368  C  CD1   . PHE A 1 45  ? 133.574 102.481 121.629 1.00 43.53 ? 45  PHE A CD1   1 
ATOM   369  C  CD2   . PHE A 1 45  ? 131.565 103.572 122.282 1.00 43.53 ? 45  PHE A CD2   1 
ATOM   370  C  CE1   . PHE A 1 45  ? 132.869 101.316 121.414 1.00 43.53 ? 45  PHE A CE1   1 
ATOM   371  C  CE2   . PHE A 1 45  ? 130.859 102.413 122.069 1.00 43.53 ? 45  PHE A CE2   1 
ATOM   372  C  CZ    . PHE A 1 45  ? 131.510 101.284 121.635 1.00 43.53 ? 45  PHE A CZ    1 
ATOM   373  N  N     . GLY A 1 46  ? 135.343 106.768 120.037 1.00 42.35 ? 46  GLY A N     1 
ATOM   374  C  CA    . GLY A 1 46  ? 135.507 108.151 119.653 1.00 42.35 ? 46  GLY A CA    1 
ATOM   375  C  C     . GLY A 1 46  ? 134.235 108.937 119.902 1.00 42.35 ? 46  GLY A C     1 
ATOM   376  O  O     . GLY A 1 46  ? 133.130 108.442 119.706 1.00 42.35 ? 46  GLY A O     1 
ATOM   377  N  N     . TYR A 1 47  ? 134.402 110.176 120.347 1.00 42.84 ? 47  TYR A N     1 
ATOM   378  C  CA    . TYR A 1 47  ? 133.254 111.011 120.661 1.00 42.84 ? 47  TYR A CA    1 
ATOM   379  C  C     . TYR A 1 47  ? 133.635 112.467 120.459 1.00 42.84 ? 47  TYR A C     1 
ATOM   380  O  O     . TYR A 1 47  ? 134.812 112.833 120.474 1.00 42.84 ? 47  TYR A O     1 
ATOM   381  C  CB    . TYR A 1 47  ? 132.757 110.759 122.085 1.00 42.84 ? 47  TYR A CB    1 
ATOM   382  C  CG    . TYR A 1 47  ? 133.768 111.065 123.163 1.00 42.84 ? 47  TYR A CG    1 
ATOM   383  C  CD1   . TYR A 1 47  ? 134.730 110.136 123.520 1.00 42.84 ? 47  TYR A CD1   1 
ATOM   384  C  CD2   . TYR A 1 47  ? 133.747 112.274 123.839 1.00 42.84 ? 47  TYR A CD2   1 
ATOM   385  C  CE1   . TYR A 1 47  ? 135.651 110.404 124.505 1.00 42.84 ? 47  TYR A CE1   1 
ATOM   386  C  CE2   . TYR A 1 47  ? 134.665 112.552 124.828 1.00 42.84 ? 47  TYR A CE2   1 
ATOM   387  C  CZ    . TYR A 1 47  ? 135.614 111.612 125.156 1.00 42.84 ? 47  TYR A CZ    1 
ATOM   388  O  OH    . TYR A 1 47  ? 136.532 111.882 126.141 1.00 42.84 ? 47  TYR A OH    1 
ATOM   389  N  N     . ALA A 1 48  ? 132.615 113.294 120.265 1.00 45.94 ? 48  ALA A N     1 
ATOM   390  C  CA    . ALA A 1 48  ? 132.784 114.728 120.102 1.00 45.94 ? 48  ALA A CA    1 
ATOM   391  C  C     . ALA A 1 48  ? 132.472 115.414 121.423 1.00 45.94 ? 48  ALA A C     1 
ATOM   392  O  O     . ALA A 1 48  ? 131.463 115.102 122.063 1.00 45.94 ? 48  ALA A O     1 
ATOM   393  C  CB    . ALA A 1 48  ? 131.875 115.260 118.996 1.00 45.94 ? 48  ALA A CB    1 
ATOM   394  N  N     . ALA A 1 49  ? 133.344 116.328 121.840 1.00 54.25 ? 49  ALA A N     1 
ATOM   395  C  CA    . ALA A 1 49  ? 133.118 117.045 123.086 1.00 54.25 ? 49  ALA A CA    1 
ATOM   396  C  C     . ALA A 1 49  ? 131.844 117.875 122.997 1.00 54.25 ? 49  ALA A C     1 
ATOM   397  O  O     . ALA A 1 49  ? 131.612 118.583 122.014 1.00 54.25 ? 49  ALA A O     1 
ATOM   398  C  CB    . ALA A 1 49  ? 134.315 117.937 123.410 1.00 54.25 ? 49  ALA A CB    1 
ATOM   399  N  N     . ARG A 1 50  ? 131.012 117.782 124.034 1.00 56.73 ? 50  ARG A N     1 
ATOM   400  C  CA    . ARG A 1 50  ? 129.728 118.471 124.039 1.00 56.73 ? 50  ARG A CA    1 
ATOM   401  C  C     . ARG A 1 50  ? 129.832 119.930 124.459 1.00 56.73 ? 50  ARG A C     1 
ATOM   402  O  O     . ARG A 1 50  ? 128.843 120.661 124.339 1.00 56.73 ? 50  ARG A O     1 
ATOM   403  C  CB    . ARG A 1 50  ? 128.744 117.750 124.965 1.00 56.73 ? 50  ARG A CB    1 
ATOM   404  C  CG    . ARG A 1 50  ? 128.849 116.235 124.953 1.00 56.73 ? 50  ARG A CG    1 
ATOM   405  C  CD    . ARG A 1 50  ? 127.880 115.613 125.949 1.00 56.73 ? 50  ARG A CD    1 
ATOM   406  N  NE    . ARG A 1 50  ? 126.499 115.672 125.484 1.00 56.73 ? 50  ARG A NE    1 
ATOM   407  C  CZ    . ARG A 1 50  ? 125.714 114.615 125.331 1.00 56.73 ? 50  ARG A CZ    1 
ATOM   408  N  NH1   . ARG A 1 50  ? 126.134 113.396 125.618 1.00 56.73 ? 50  ARG A NH1   1 
ATOM   409  N  NH2   . ARG A 1 50  ? 124.475 114.786 124.880 1.00 56.73 ? 50  ARG A NH2   1 
ATOM   410  N  N     . GLU A 1 51  ? 130.994 120.372 124.939 1.00 65.48 ? 51  GLU A N     1 
ATOM   411  C  CA    . GLU A 1 51  ? 131.128 121.720 125.475 1.00 65.48 ? 51  GLU A CA    1 
ATOM   412  C  C     . GLU A 1 51  ? 131.312 122.784 124.399 1.00 65.48 ? 51  GLU A C     1 
ATOM   413  O  O     . GLU A 1 51  ? 131.301 123.975 124.728 1.00 65.48 ? 51  GLU A O     1 
ATOM   414  C  CB    . GLU A 1 51  ? 132.288 121.768 126.475 1.00 65.48 ? 51  GLU A CB    1 
ATOM   415  C  CG    . GLU A 1 51  ? 133.641 121.354 125.917 1.00 65.48 ? 51  GLU A CG    1 
ATOM   416  C  CD    . GLU A 1 51  ? 134.430 122.520 125.357 1.00 65.48 ? 51  GLU A CD    1 
ATOM   417  O  OE1   . GLU A 1 51  ? 134.098 123.679 125.686 1.00 65.48 ? 51  GLU A OE1   1 
ATOM   418  O  OE2   . GLU A 1 51  ? 135.394 122.277 124.602 1.00 65.48 ? 51  GLU A OE2   1 
ATOM   419  N  N     . ASP A 1 52  ? 131.476 122.396 123.131 1.00 64.92 ? 52  ASP A N     1 
ATOM   420  C  CA    . ASP A 1 52  ? 131.554 123.368 122.047 1.00 64.92 ? 52  ASP A CA    1 
ATOM   421  C  C     . ASP A 1 52  ? 130.735 122.927 120.840 1.00 64.92 ? 52  ASP A C     1 
ATOM   422  O  O     . ASP A 1 52  ? 131.119 123.194 119.696 1.00 64.92 ? 52  ASP A O     1 
ATOM   423  C  CB    . ASP A 1 52  ? 133.004 123.619 121.627 1.00 64.92 ? 52  ASP A CB    1 
ATOM   424  C  CG    . ASP A 1 52  ? 133.784 122.338 121.419 1.00 64.92 ? 52  ASP A CG    1 
ATOM   425  O  OD1   . ASP A 1 52  ? 133.264 121.417 120.755 1.00 64.92 ? 52  ASP A OD1   1 
ATOM   426  O  OD2   . ASP A 1 52  ? 134.927 122.254 121.911 1.00 64.92 ? 52  ASP A OD2   1 
ATOM   427  N  N     . ASP A 1 53  ? 129.606 122.256 121.078 1.00 64.95 ? 53  ASP A N     1 
ATOM   428  C  CA    . ASP A 1 53  ? 128.739 121.749 120.012 1.00 64.95 ? 53  ASP A CA    1 
ATOM   429  C  C     . ASP A 1 53  ? 129.508 120.855 119.043 1.00 64.95 ? 53  ASP A C     1 
ATOM   430  O  O     . ASP A 1 53  ? 129.328 120.924 117.827 1.00 64.95 ? 53  ASP A O     1 
ATOM   431  C  CB    . ASP A 1 53  ? 128.049 122.893 119.266 1.00 64.95 ? 53  ASP A CB    1 
ATOM   432  C  CG    . ASP A 1 53  ? 126.988 123.576 120.103 1.00 64.95 ? 53  ASP A CG    1 
ATOM   433  O  OD1   . ASP A 1 53  ? 126.870 123.243 121.301 1.00 64.95 ? 53  ASP A OD1   1 
ATOM   434  O  OD2   . ASP A 1 53  ? 126.270 124.445 119.565 1.00 64.95 ? 53  ASP A OD2   1 
ATOM   435  N  N     . GLY A 1 54  ? 130.379 120.009 119.587 1.00 58.15 ? 54  GLY A N     1 
ATOM   436  C  CA    . GLY A 1 54  ? 131.092 119.049 118.769 1.00 58.15 ? 54  GLY A CA    1 
ATOM   437  C  C     . GLY A 1 54  ? 132.150 119.634 117.866 1.00 58.15 ? 54  GLY A C     1 
ATOM   438  O  O     . GLY A 1 54  ? 132.516 119.002 116.873 1.00 58.15 ? 54  GLY A O     1 
ATOM   439  N  N     . ALA A 1 55  ? 132.653 120.831 118.178 1.00 62.47 ? 55  ALA A N     1 
ATOM   440  C  CA    . ALA A 1 55  ? 133.691 121.433 117.347 1.00 62.47 ? 55  ALA A CA    1 
ATOM   441  C  C     . ALA A 1 55  ? 134.958 120.590 117.355 1.00 62.47 ? 55  ALA A C     1 
ATOM   442  O  O     . ALA A 1 55  ? 135.588 120.390 116.309 1.00 62.47 ? 55  ALA A O     1 
ATOM   443  C  CB    . ALA A 1 55  ? 133.987 122.855 117.820 1.00 62.47 ? 55  ALA A CB    1 
ATOM   444  N  N     . THR A 1 56  ? 135.348 120.090 118.519 1.00 59.68 ? 56  THR A N     1 
ATOM   445  C  CA    . THR A 1 56  ? 136.471 119.177 118.654 1.00 59.68 ? 56  THR A CA    1 
ATOM   446  C  C     . THR A 1 56  ? 135.945 117.766 118.898 1.00 59.68 ? 56  THR A C     1 
ATOM   447  O  O     . THR A 1 56  ? 134.736 117.523 118.911 1.00 59.68 ? 56  THR A O     1 
ATOM   448  C  CB    . THR A 1 56  ? 137.405 119.628 119.778 1.00 59.68 ? 56  THR A CB    1 
ATOM   449  O  OG1   . THR A 1 56  ? 138.571 118.796 119.797 1.00 59.68 ? 56  THR A OG1   1 
ATOM   450  C  CG2   . THR A 1 56  ? 136.705 119.541 121.122 1.00 59.68 ? 56  THR A CG2   1 
ATOM   451  N  N     . TYR A 1 57  ? 136.868 116.830 119.088 1.00 55.25 ? 57  TYR A N     1 
ATOM   452  C  CA    . TYR A 1 57  ? 136.514 115.435 119.315 1.00 55.25 ? 57  TYR A CA    1 
ATOM   453  C  C     . TYR A 1 57  ? 137.714 114.724 119.925 1.00 55.25 ? 57  TYR A C     1 
ATOM   454  O  O     . TYR A 1 57  ? 138.773 115.320 120.137 1.00 55.25 ? 57  TYR A O     1 
ATOM   455  C  CB    . TYR A 1 57  ? 136.062 114.758 118.017 1.00 55.25 ? 57  TYR A CB    1 
ATOM   456  C  CG    . TYR A 1 57  ? 137.148 114.629 116.971 1.00 55.25 ? 57  TYR A CG    1 
ATOM   457  C  CD1   . TYR A 1 57  ? 137.350 115.626 116.027 1.00 55.25 ? 57  TYR A CD1   1 
ATOM   458  C  CD2   . TYR A 1 57  ? 137.964 113.507 116.921 1.00 55.25 ? 57  TYR A CD2   1 
ATOM   459  C  CE1   . TYR A 1 57  ? 138.337 115.511 115.069 1.00 55.25 ? 57  TYR A CE1   1 
ATOM   460  C  CE2   . TYR A 1 57  ? 138.953 113.386 115.968 1.00 55.25 ? 57  TYR A CE2   1 
ATOM   461  C  CZ    . TYR A 1 57  ? 139.136 114.389 115.045 1.00 55.25 ? 57  TYR A CZ    1 
ATOM   462  O  OH    . TYR A 1 57  ? 140.121 114.269 114.094 1.00 55.25 ? 57  TYR A OH    1 
ATOM   463  N  N     . ILE A 1 58  ? 137.537 113.438 120.207 1.00 52.28 ? 58  ILE A N     1 
ATOM   464  C  CA    . ILE A 1 58  ? 138.608 112.577 120.693 1.00 52.28 ? 58  ILE A CA    1 
ATOM   465  C  C     . ILE A 1 58  ? 138.738 111.407 119.731 1.00 52.28 ? 58  ILE A C     1 
ATOM   466  O  O     . ILE A 1 58  ? 137.810 110.601 119.595 1.00 52.28 ? 58  ILE A O     1 
ATOM   467  C  CB    . ILE A 1 58  ? 138.345 112.084 122.124 1.00 52.28 ? 58  ILE A CB    1 
ATOM   468  C  CG1   . ILE A 1 58  ? 138.209 113.269 123.080 1.00 52.28 ? 58  ILE A CG1   1 
ATOM   469  C  CG2   . ILE A 1 58  ? 139.447 111.145 122.579 1.00 52.28 ? 58  ILE A CG2   1 
ATOM   470  C  CD1   . ILE A 1 58  ? 139.442 114.128 123.160 1.00 52.28 ? 58  ILE A CD1   1 
ATOM   471  N  N     . SER A 1 59  ? 139.886 111.312 119.069 1.00 58.26 ? 59  SER A N     1 
ATOM   472  C  CA    . SER A 1 59  ? 140.115 110.244 118.118 1.00 58.26 ? 59  SER A CA    1 
ATOM   473  C  C     . SER A 1 59  ? 140.215 108.906 118.842 1.00 58.26 ? 59  SER A C     1 
ATOM   474  O  O     . SER A 1 59  ? 140.561 108.855 120.024 1.00 58.26 ? 59  SER A O     1 
ATOM   475  C  CB    . SER A 1 59  ? 141.391 110.509 117.326 1.00 58.26 ? 59  SER A CB    1 
ATOM   476  O  OG    . SER A 1 59  ? 142.538 110.261 118.120 1.00 58.26 ? 59  SER A OG    1 
ATOM   477  N  N     . PRO A 1 60  ? 139.904 107.803 118.157 1.00 57.35 ? 60  PRO A N     1 
ATOM   478  C  CA    . PRO A 1 60  ? 140.050 106.489 118.799 1.00 57.35 ? 60  PRO A CA    1 
ATOM   479  C  C     . PRO A 1 60  ? 141.476 106.177 119.207 1.00 57.35 ? 60  PRO A C     1 
ATOM   480  O  O     . PRO A 1 60  ? 141.678 105.359 120.110 1.00 57.35 ? 60  PRO A O     1 
ATOM   481  C  CB    . PRO A 1 60  ? 139.541 105.516 117.728 1.00 57.35 ? 60  PRO A CB    1 
ATOM   482  C  CG    . PRO A 1 60  ? 138.661 106.336 116.861 1.00 57.35 ? 60  PRO A CG    1 
ATOM   483  C  CD    . PRO A 1 60  ? 139.295 107.692 116.824 1.00 57.35 ? 60  PRO A CD    1 
ATOM   484  N  N     . SER A 1 61  ? 142.475 106.791 118.568 1.00 62.04 ? 61  SER A N     1 
ATOM   485  C  CA    . SER A 1 61  ? 143.855 106.593 119.004 1.00 62.04 ? 61  SER A CA    1 
ATOM   486  C  C     . SER A 1 61  ? 144.126 107.308 120.323 1.00 62.04 ? 61  SER A C     1 
ATOM   487  O  O     . SER A 1 61  ? 144.780 106.753 121.216 1.00 62.04 ? 61  SER A O     1 
ATOM   488  C  CB    . SER A 1 61  ? 144.821 107.065 117.920 1.00 62.04 ? 61  SER A CB    1 
ATOM   489  O  OG    . SER A 1 61  ? 144.490 106.491 116.669 1.00 62.04 ? 61  SER A OG    1 
ATOM   490  N  N     . GLN A 1 62  ? 143.626 108.538 120.469 1.00 62.41 ? 62  GLN A N     1 
ATOM   491  C  CA    . GLN A 1 62  ? 143.705 109.211 121.761 1.00 62.41 ? 62  GLN A CA    1 
ATOM   492  C  C     . GLN A 1 62  ? 142.945 108.430 122.823 1.00 62.41 ? 62  GLN A C     1 
ATOM   493  O  O     . GLN A 1 62  ? 143.390 108.330 123.974 1.00 62.41 ? 62  GLN A O     1 
ATOM   494  C  CB    . GLN A 1 62  ? 143.152 110.631 121.652 1.00 62.41 ? 62  GLN A CB    1 
ATOM   495  C  CG    . GLN A 1 62  ? 143.991 111.566 120.810 1.00 62.41 ? 62  GLN A CG    1 
ATOM   496  C  CD    . GLN A 1 62  ? 143.426 112.968 120.779 1.00 62.41 ? 62  GLN A CD    1 
ATOM   497  O  OE1   . GLN A 1 62  ? 142.372 113.237 121.354 1.00 62.41 ? 62  GLN A OE1   1 
ATOM   498  N  NE2   . GLN A 1 62  ? 144.126 113.873 120.105 1.00 62.41 ? 62  GLN A NE2   1 
ATOM   499  N  N     . ALA A 1 63  ? 141.790 107.873 122.453 1.00 64.05 ? 63  ALA A N     1 
ATOM   500  C  CA    . ALA A 1 63  ? 141.031 107.045 123.381 1.00 64.05 ? 63  ALA A CA    1 
ATOM   501  C  C     . ALA A 1 63  ? 141.821 105.809 123.786 1.00 64.05 ? 63  ALA A C     1 
ATOM   502  O  O     . ALA A 1 63  ? 141.796 105.405 124.952 1.00 64.05 ? 63  ALA A O     1 
ATOM   503  C  CB    . ALA A 1 63  ? 139.694 106.650 122.757 1.00 64.05 ? 63  ALA A CB    1 
ATOM   504  N  N     . LEU A 1 64  ? 142.523 105.190 122.835 1.00 63.77 ? 64  LEU A N     1 
ATOM   505  C  CA    . LEU A 1 64  ? 143.343 104.028 123.158 1.00 63.77 ? 64  LEU A CA    1 
ATOM   506  C  C     . LEU A 1 64  ? 144.475 104.403 124.104 1.00 63.77 ? 64  LEU A C     1 
ATOM   507  O  O     . LEU A 1 64  ? 144.785 103.660 125.044 1.00 63.77 ? 64  LEU A O     1 
ATOM   508  C  CB    . LEU A 1 64  ? 143.894 103.406 121.876 1.00 63.77 ? 64  LEU A CB    1 
ATOM   509  C  CG    . LEU A 1 64  ? 142.923 102.543 121.069 1.00 63.77 ? 64  LEU A CG    1 
ATOM   510  C  CD1   . LEU A 1 64  ? 143.465 102.286 119.675 1.00 63.77 ? 64  LEU A CD1   1 
ATOM   511  C  CD2   . LEU A 1 64  ? 142.654 101.235 121.781 1.00 63.77 ? 64  LEU A CD2   1 
ATOM   512  N  N     . LEU A 1 65  ? 145.102 105.557 123.872 1.00 67.91 ? 65  LEU A N     1 
ATOM   513  C  CA    . LEU A 1 65  ? 146.161 106.010 124.768 1.00 67.91 ? 65  LEU A CA    1 
ATOM   514  C  C     . LEU A 1 65  ? 145.625 106.262 126.173 1.00 67.91 ? 65  LEU A C     1 
ATOM   515  O  O     . LEU A 1 65  ? 146.248 105.864 127.166 1.00 67.91 ? 65  LEU A O     1 
ATOM   516  C  CB    . LEU A 1 65  ? 146.818 107.270 124.205 1.00 67.91 ? 65  LEU A CB    1 
ATOM   517  C  CG    . LEU A 1 65  ? 147.928 107.898 125.046 1.00 67.91 ? 65  LEU A CG    1 
ATOM   518  C  CD1   . LEU A 1 65  ? 149.130 106.969 125.130 1.00 67.91 ? 65  LEU A CD1   1 
ATOM   519  C  CD2   . LEU A 1 65  ? 148.325 109.246 124.467 1.00 67.91 ? 65  LEU A CD2   1 
ATOM   520  N  N     . GLU A 1 66  ? 144.462 106.909 126.278 1.00 69.15 ? 66  GLU A N     1 
ATOM   521  C  CA    . GLU A 1 66  ? 143.869 107.160 127.590 1.00 69.15 ? 66  GLU A CA    1 
ATOM   522  C  C     . GLU A 1 66  ? 143.481 105.858 128.283 1.00 69.15 ? 66  GLU A C     1 
ATOM   523  O  O     . GLU A 1 66  ? 143.660 105.717 129.499 1.00 69.15 ? 66  GLU A O     1 
ATOM   524  C  CB    . GLU A 1 66  ? 142.656 108.078 127.451 1.00 69.15 ? 66  GLU A CB    1 
ATOM   525  C  CG    . GLU A 1 66  ? 142.990 109.477 126.965 1.00 69.15 ? 66  GLU A CG    1 
ATOM   526  C  CD    . GLU A 1 66  ? 141.944 110.496 127.367 1.00 69.15 ? 66  GLU A CD    1 
ATOM   527  O  OE1   . GLU A 1 66  ? 140.809 110.087 127.687 1.00 69.15 ? 66  GLU A OE1   1 
ATOM   528  O  OE2   . GLU A 1 66  ? 142.256 111.705 127.364 1.00 69.15 ? 66  GLU A OE2   1 
ATOM   529  N  N     . ARG A 1 67  ? 142.943 104.900 127.526 1.00 65.55 ? 67  ARG A N     1 
ATOM   530  C  CA    . ARG A 1 67  ? 142.609 103.600 128.094 1.00 65.55 ? 67  ARG A CA    1 
ATOM   531  C  C     . ARG A 1 67  ? 143.848 102.906 128.636 1.00 65.55 ? 67  ARG A C     1 
ATOM   532  O  O     . ARG A 1 67  ? 143.826 102.352 129.741 1.00 65.55 ? 67  ARG A O     1 
ATOM   533  C  CB    . ARG A 1 67  ? 141.933 102.728 127.039 1.00 65.55 ? 67  ARG A CB    1 
ATOM   534  C  CG    . ARG A 1 67  ? 141.769 101.280 127.455 1.00 65.55 ? 67  ARG A CG    1 
ATOM   535  C  CD    . ARG A 1 67  ? 141.239 100.440 126.314 1.00 65.55 ? 67  ARG A CD    1 
ATOM   536  N  NE    . ARG A 1 67  ? 142.327 99.869  125.533 1.00 65.55 ? 67  ARG A NE    1 
ATOM   537  C  CZ    . ARG A 1 67  ? 142.162 99.080  124.480 1.00 65.55 ? 67  ARG A CZ    1 
ATOM   538  N  NH1   . ARG A 1 67  ? 140.956 98.747  124.050 1.00 65.55 ? 67  ARG A NH1   1 
ATOM   539  N  NH2   . ARG A 1 67  ? 143.232 98.616  123.843 1.00 65.55 ? 67  ARG A NH2   1 
ATOM   540  N  N     . ARG A 1 68  ? 144.943 102.926 127.872 1.00 71.78 ? 68  ARG A N     1 
ATOM   541  C  CA    . ARG A 1 68  ? 146.185 102.339 128.361 1.00 71.78 ? 68  ARG A CA    1 
ATOM   542  C  C     . ARG A 1 68  ? 146.707 103.086 129.581 1.00 71.78 ? 68  ARG A C     1 
ATOM   543  O  O     . ARG A 1 68  ? 147.364 102.487 130.440 1.00 71.78 ? 68  ARG A O     1 
ATOM   544  C  CB    . ARG A 1 68  ? 147.232 102.324 127.250 1.00 71.78 ? 68  ARG A CB    1 
ATOM   545  C  CG    . ARG A 1 68  ? 147.091 101.147 126.304 1.00 71.78 ? 68  ARG A CG    1 
ATOM   546  C  CD    . ARG A 1 68  ? 148.442 100.615 125.859 1.00 71.78 ? 68  ARG A CD    1 
ATOM   547  N  NE    . ARG A 1 68  ? 148.332 99.820  124.642 1.00 71.78 ? 68  ARG A NE    1 
ATOM   548  C  CZ    . ARG A 1 68  ? 148.102 98.514  124.619 1.00 71.78 ? 68  ARG A CZ    1 
ATOM   549  N  NH1   . ARG A 1 68  ? 147.952 97.819  125.735 1.00 71.78 ? 68  ARG A NH1   1 
ATOM   550  N  NH2   . ARG A 1 68  ? 148.019 97.890  123.448 1.00 71.78 ? 68  ARG A NH2   1 
ATOM   551  N  N     . LEU A 1 69  ? 146.432 104.388 129.667 1.00 72.92 ? 69  LEU A N     1 
ATOM   552  C  CA    . LEU A 1 69  ? 146.791 105.145 130.862 1.00 72.92 ? 69  LEU A CA    1 
ATOM   553  C  C     . LEU A 1 69  ? 146.005 104.664 132.077 1.00 72.92 ? 69  LEU A C     1 
ATOM   554  O  O     . LEU A 1 69  ? 146.563 104.512 133.170 1.00 72.92 ? 69  LEU A O     1 
ATOM   555  C  CB    . LEU A 1 69  ? 146.557 106.637 130.625 1.00 72.92 ? 69  LEU A CB    1 
ATOM   556  C  CG    . LEU A 1 69  ? 147.703 107.420 129.982 1.00 72.92 ? 69  LEU A CG    1 
ATOM   557  C  CD1   . LEU A 1 69  ? 147.412 108.914 130.011 1.00 72.92 ? 69  LEU A CD1   1 
ATOM   558  C  CD2   . LEU A 1 69  ? 149.023 107.110 130.676 1.00 72.92 ? 69  LEU A CD2   1 
ATOM   559  N  N     . LEU A 1 70  ? 144.705 104.414 131.904 1.00 69.68 ? 70  LEU A N     1 
ATOM   560  C  CA    . LEU A 1 70  ? 143.860 104.056 133.043 1.00 69.68 ? 70  LEU A CA    1 
ATOM   561  C  C     . LEU A 1 70  ? 144.083 102.616 133.485 1.00 69.68 ? 70  LEU A C     1 
ATOM   562  O  O     . LEU A 1 70  ? 144.513 102.359 134.615 1.00 69.68 ? 70  LEU A O     1 
ATOM   563  C  CB    . LEU A 1 70  ? 142.383 104.258 132.697 1.00 69.68 ? 70  LEU A CB    1 
ATOM   564  C  CG    . LEU A 1 70  ? 141.831 105.655 132.438 1.00 69.68 ? 70  LEU A CG    1 
ATOM   565  C  CD1   . LEU A 1 70  ? 140.394 105.522 131.987 1.00 69.68 ? 70  LEU A CD1   1 
ATOM   566  C  CD2   . LEU A 1 70  ? 141.928 106.516 133.684 1.00 69.68 ? 70  LEU A CD2   1 
ATOM   567  N  N     . LEU A 1 71  ? 143.780 101.662 132.605 1.00 71.64 ? 71  LEU A N     1 
ATOM   568  C  CA    . LEU A 1 71  ? 143.811 100.255 132.990 1.00 71.64 ? 71  LEU A CA    1 
ATOM   569  C  C     . LEU A 1 71  ? 145.231 99.785  133.269 1.00 71.64 ? 71  LEU A C     1 
ATOM   570  O  O     . LEU A 1 71  ? 145.476 99.068  134.246 1.00 71.64 ? 71  LEU A O     1 
ATOM   571  C  CB    . LEU A 1 71  ? 143.172 99.403  131.897 1.00 71.64 ? 71  LEU A CB    1 
ATOM   572  C  CG    . LEU A 1 71  ? 141.651 99.360  131.784 1.00 71.64 ? 71  LEU A CG    1 
ATOM   573  C  CD1   . LEU A 1 71  ? 141.087 100.666 131.259 1.00 71.64 ? 71  LEU A CD1   1 
ATOM   574  C  CD2   . LEU A 1 71  ? 141.284 98.238  130.856 1.00 71.64 ? 71  LEU A CD2   1 
ATOM   575  N  N     . GLY A 1 72  ? 146.181 100.178 132.426 1.00 74.76 ? 72  GLY A N     1 
ATOM   576  C  CA    . GLY A 1 72  ? 147.551 99.746  132.599 1.00 74.76 ? 72  GLY A CA    1 
ATOM   577  C  C     . GLY A 1 72  ? 147.779 98.303  132.200 1.00 74.76 ? 72  GLY A C     1 
ATOM   578  O  O     . GLY A 1 72  ? 147.752 97.967  131.012 1.00 74.76 ? 72  GLY A O     1 
ATOM   579  N  N     . ASP A 1 73  ? 148.004 97.437  133.186 1.00 81.94 ? 73  ASP A N     1 
ATOM   580  C  CA    . ASP A 1 73  ? 148.325 96.041  132.921 1.00 81.94 ? 73  ASP A CA    1 
ATOM   581  C  C     . ASP A 1 73  ? 147.095 95.165  132.726 1.00 81.94 ? 73  ASP A C     1 
ATOM   582  O  O     . ASP A 1 73  ? 147.247 93.964  132.480 1.00 81.94 ? 73  ASP A O     1 
ATOM   583  C  CB    . ASP A 1 73  ? 149.177 95.478  134.062 1.00 81.94 ? 73  ASP A CB    1 
ATOM   584  C  CG    . ASP A 1 73  ? 150.103 94.369  133.605 1.00 81.94 ? 73  ASP A CG    1 
ATOM   585  O  OD1   . ASP A 1 73  ? 150.109 94.058  132.395 1.00 81.94 ? 73  ASP A OD1   1 
ATOM   586  O  OD2   . ASP A 1 73  ? 150.827 93.810  134.454 1.00 81.94 ? 73  ASP A OD2   1 
ATOM   587  N  N     . ALA A 1 74  ? 145.889 95.722  132.832 1.00 78.33 ? 74  ALA A N     1 
ATOM   588  C  CA    . ALA A 1 74  ? 144.657 94.946  132.756 1.00 78.33 ? 74  ALA A CA    1 
ATOM   589  C  C     . ALA A 1 74  ? 143.829 95.287  131.521 1.00 78.33 ? 74  ALA A C     1 
ATOM   590  O  O     . ALA A 1 74  ? 142.599 95.326  131.587 1.00 78.33 ? 74  ALA A O     1 
ATOM   591  C  CB    . ALA A 1 74  ? 143.827 95.145  134.023 1.00 78.33 ? 74  ALA A CB    1 
ATOM   592  N  N     . GLU A 1 75  ? 144.485 95.540  130.387 1.00 76.21 ? 75  GLU A N     1 
ATOM   593  C  CA    . GLU A 1 75  ? 143.744 95.857  129.170 1.00 76.21 ? 75  GLU A CA    1 
ATOM   594  C  C     . GLU A 1 75  ? 143.018 94.634  128.624 1.00 76.21 ? 75  GLU A C     1 
ATOM   595  O  O     . GLU A 1 75  ? 141.834 94.711  128.280 1.00 76.21 ? 75  GLU A O     1 
ATOM   596  C  CB    . GLU A 1 75  ? 144.685 96.419  128.106 1.00 76.21 ? 75  GLU A CB    1 
ATOM   597  C  CG    . GLU A 1 75  ? 145.667 97.464  128.598 1.00 76.21 ? 75  GLU A CG    1 
ATOM   598  C  CD    . GLU A 1 75  ? 144.990 98.715  129.112 1.00 76.21 ? 75  GLU A CD    1 
ATOM   599  O  OE1   . GLU A 1 75  ? 143.863 99.014  128.663 1.00 76.21 ? 75  GLU A OE1   1 
ATOM   600  O  OE2   . GLU A 1 75  ? 145.596 99.408  129.956 1.00 76.21 ? 75  GLU A OE2   1 
ATOM   601  N  N     . ASP A 1 76  ? 143.713 93.499  128.541 1.00 77.36 ? 76  ASP A N     1 
ATOM   602  C  CA    . ASP A 1 76  ? 143.180 92.336  127.838 1.00 77.36 ? 76  ASP A CA    1 
ATOM   603  C  C     . ASP A 1 76  ? 141.979 91.739  128.564 1.00 77.36 ? 76  ASP A C     1 
ATOM   604  O  O     . ASP A 1 76  ? 140.981 91.361  127.934 1.00 77.36 ? 76  ASP A O     1 
ATOM   605  C  CB    . ASP A 1 76  ? 144.287 91.295  127.670 1.00 77.36 ? 76  ASP A CB    1 
ATOM   606  C  CG    . ASP A 1 76  ? 145.023 91.012  128.966 1.00 77.36 ? 76  ASP A CG    1 
ATOM   607  O  OD1   . ASP A 1 76  ? 144.710 91.665  129.984 1.00 77.36 ? 76  ASP A OD1   1 
ATOM   608  O  OD2   . ASP A 1 76  ? 145.912 90.136  128.969 1.00 77.36 ? 76  ASP A OD2   1 
ATOM   609  N  N     . VAL A 1 77  ? 142.065 91.629  129.892 1.00 73.76 ? 77  VAL A N     1 
ATOM   610  C  CA    . VAL A 1 77  ? 140.965 91.053  130.660 1.00 73.76 ? 77  VAL A CA    1 
ATOM   611  C  C     . VAL A 1 77  ? 139.712 91.905  130.514 1.00 73.76 ? 77  VAL A C     1 
ATOM   612  O  O     . VAL A 1 77  ? 138.606 91.385  130.317 1.00 73.76 ? 77  VAL A O     1 
ATOM   613  C  CB    . VAL A 1 77  ? 141.378 90.871  132.133 1.00 73.76 ? 77  VAL A CB    1 
ATOM   614  C  CG1   . VAL A 1 77  ? 142.461 89.810  132.244 1.00 73.76 ? 77  VAL A CG1   1 
ATOM   615  C  CG2   . VAL A 1 77  ? 141.881 92.181  132.723 1.00 73.76 ? 77  VAL A CG2   1 
ATOM   616  N  N     . ALA A 1 78  ? 139.867 93.229  130.581 1.00 68.72 ? 78  ALA A N     1 
ATOM   617  C  CA    . ALA A 1 78  ? 138.730 94.111  130.364 1.00 68.72 ? 78  ALA A CA    1 
ATOM   618  C  C     . ALA A 1 78  ? 138.221 94.024  128.935 1.00 68.72 ? 78  ALA A C     1 
ATOM   619  O  O     . ALA A 1 78  ? 137.018 94.162  128.701 1.00 68.72 ? 78  ALA A O     1 
ATOM   620  C  CB    . ALA A 1 78  ? 139.104 95.549  130.705 1.00 68.72 ? 78  ALA A CB    1 
ATOM   621  N  N     . ILE A 1 79  ? 139.112 93.794  127.968 1.00 69.02 ? 79  ILE A N     1 
ATOM   622  C  CA    . ILE A 1 79  ? 138.673 93.651  126.582 1.00 69.02 ? 79  ILE A CA    1 
ATOM   623  C  C     . ILE A 1 79  ? 137.755 92.444  126.438 1.00 69.02 ? 79  ILE A C     1 
ATOM   624  O  O     . ILE A 1 79  ? 136.662 92.540  125.868 1.00 69.02 ? 79  ILE A O     1 
ATOM   625  C  CB    . ILE A 1 79  ? 139.885 93.558  125.637 1.00 69.02 ? 79  ILE A CB    1 
ATOM   626  C  CG1   . ILE A 1 79  ? 140.538 94.931  125.473 1.00 69.02 ? 79  ILE A CG1   1 
ATOM   627  C  CG2   . ILE A 1 79  ? 139.468 93.003  124.285 1.00 69.02 ? 79  ILE A CG2   1 
ATOM   628  C  CD1   . ILE A 1 79  ? 141.924 94.877  124.875 1.00 69.02 ? 79  ILE A CD1   1 
ATOM   629  N  N     . LYS A 1 80  ? 138.177 91.290  126.967 1.00 68.67 ? 80  LYS A N     1 
ATOM   630  C  CA    . LYS A 1 80  ? 137.302 90.119  126.897 1.00 68.67 ? 80  LYS A CA    1 
ATOM   631  C  C     . LYS A 1 80  ? 136.015 90.321  127.692 1.00 68.67 ? 80  LYS A C     1 
ATOM   632  O  O     . LYS A 1 80  ? 134.935 89.920  127.236 1.00 68.67 ? 80  LYS A O     1 
ATOM   633  C  CB    . LYS A 1 80  ? 138.005 88.840  127.359 1.00 68.67 ? 80  LYS A CB    1 
ATOM   634  C  CG    . LYS A 1 80  ? 138.771 88.104  126.262 1.00 68.67 ? 80  LYS A CG    1 
ATOM   635  C  CD    . LYS A 1 80  ? 140.098 88.713  125.880 1.00 68.67 ? 80  LYS A CD    1 
ATOM   636  C  CE    . LYS A 1 80  ? 141.110 88.490  126.987 1.00 68.67 ? 80  LYS A CE    1 
ATOM   637  N  NZ    . LYS A 1 80  ? 142.448 88.999  126.608 1.00 68.67 ? 80  LYS A NZ    1 
ATOM   638  N  N     . PHE A 1 81  ? 136.101 90.924  128.883 1.00 63.90 ? 81  PHE A N     1 
ATOM   639  C  CA    . PHE A 1 81  ? 134.896 91.147  129.679 1.00 63.90 ? 81  PHE A CA    1 
ATOM   640  C  C     . PHE A 1 81  ? 133.897 92.020  128.933 1.00 63.90 ? 81  PHE A C     1 
ATOM   641  O  O     . PHE A 1 81  ? 132.702 91.710  128.870 1.00 63.90 ? 81  PHE A O     1 
ATOM   642  C  CB    . PHE A 1 81  ? 135.261 91.781  131.020 1.00 63.90 ? 81  PHE A CB    1 
ATOM   643  C  CG    . PHE A 1 81  ? 134.070 92.149  131.856 1.00 63.90 ? 81  PHE A CG    1 
ATOM   644  C  CD1   . PHE A 1 81  ? 133.454 91.210  132.663 1.00 63.90 ? 81  PHE A CD1   1 
ATOM   645  C  CD2   . PHE A 1 81  ? 133.560 93.439  131.830 1.00 63.90 ? 81  PHE A CD2   1 
ATOM   646  C  CE1   . PHE A 1 81  ? 132.356 91.549  133.427 1.00 63.90 ? 81  PHE A CE1   1 
ATOM   647  C  CE2   . PHE A 1 81  ? 132.463 93.782  132.590 1.00 63.90 ? 81  PHE A CE2   1 
ATOM   648  C  CZ    . PHE A 1 81  ? 131.861 92.837  133.391 1.00 63.90 ? 81  PHE A CZ    1 
ATOM   649  N  N     . LEU A 1 82  ? 134.372 93.112  128.344 1.00 59.83 ? 82  LEU A N     1 
ATOM   650  C  CA    . LEU A 1 82  ? 133.472 94.029  127.665 1.00 59.83 ? 82  LEU A CA    1 
ATOM   651  C  C     . LEU A 1 82  ? 132.952 93.424  126.368 1.00 59.83 ? 82  LEU A C     1 
ATOM   652  O  O     . LEU A 1 82  ? 131.815 93.691  125.964 1.00 59.83 ? 82  LEU A O     1 
ATOM   653  C  CB    . LEU A 1 82  ? 134.193 95.349  127.420 1.00 59.83 ? 82  LEU A CB    1 
ATOM   654  C  CG    . LEU A 1 82  ? 133.414 96.495  126.801 1.00 59.83 ? 82  LEU A CG    1 
ATOM   655  C  CD1   . LEU A 1 82  ? 132.282 96.899  127.715 1.00 59.83 ? 82  LEU A CD1   1 
ATOM   656  C  CD2   . LEU A 1 82  ? 134.360 97.643  126.605 1.00 59.83 ? 82  LEU A CD2   1 
ATOM   657  N  N     . ASP A 1 83  ? 133.760 92.585  125.713 1.00 62.81 ? 83  ASP A N     1 
ATOM   658  C  CA    . ASP A 1 83  ? 133.294 91.889  124.519 1.00 62.81 ? 83  ASP A CA    1 
ATOM   659  C  C     . ASP A 1 83  ? 132.157 90.931  124.854 1.00 62.81 ? 83  ASP A C     1 
ATOM   660  O  O     . ASP A 1 83  ? 131.129 90.901  124.165 1.00 62.81 ? 83  ASP A O     1 
ATOM   661  C  CB    . ASP A 1 83  ? 134.461 91.143  123.868 1.00 62.81 ? 83  ASP A CB    1 
ATOM   662  C  CG    . ASP A 1 83  ? 134.119 90.592  122.495 1.00 62.81 ? 83  ASP A CG    1 
ATOM   663  O  OD1   . ASP A 1 83  ? 132.967 90.760  122.043 1.00 62.81 ? 83  ASP A OD1   1 
ATOM   664  O  OD2   . ASP A 1 83  ? 135.011 89.990  121.863 1.00 62.81 ? 83  ASP A OD2   1 
ATOM   665  N  N     . VAL A 1 84  ? 132.319 90.138  125.918 1.00 59.88 ? 84  VAL A N     1 
ATOM   666  C  CA    . VAL A 1 84  ? 131.260 89.207  126.288 1.00 59.88 ? 84  VAL A CA    1 
ATOM   667  C  C     . VAL A 1 84  ? 130.056 89.937  126.865 1.00 59.88 ? 84  VAL A C     1 
ATOM   668  O  O     . VAL A 1 84  ? 128.942 89.402  126.837 1.00 59.88 ? 84  VAL A O     1 
ATOM   669  C  CB    . VAL A 1 84  ? 131.770 88.130  127.266 1.00 59.88 ? 84  VAL A CB    1 
ATOM   670  C  CG1   . VAL A 1 84  ? 132.991 87.425  126.692 1.00 59.88 ? 84  VAL A CG1   1 
ATOM   671  C  CG2   . VAL A 1 84  ? 132.072 88.721  128.627 1.00 59.88 ? 84  VAL A CG2   1 
ATOM   672  N  N     . LEU A 1 85  ? 130.244 91.149  127.393 1.00 54.58 ? 85  LEU A N     1 
ATOM   673  C  CA    . LEU A 1 85  ? 129.098 91.964  127.784 1.00 54.58 ? 85  LEU A CA    1 
ATOM   674  C  C     . LEU A 1 85  ? 128.323 92.435  126.561 1.00 54.58 ? 85  LEU A C     1 
ATOM   675  O  O     . LEU A 1 85  ? 127.094 92.324  126.512 1.00 54.58 ? 85  LEU A O     1 
ATOM   676  C  CB    . LEU A 1 85  ? 129.564 93.154  128.625 1.00 54.58 ? 85  LEU A CB    1 
ATOM   677  C  CG    . LEU A 1 85  ? 128.529 94.064  129.297 1.00 54.58 ? 85  LEU A CG    1 
ATOM   678  C  CD1   . LEU A 1 85  ? 129.127 94.682  130.541 1.00 54.58 ? 85  LEU A CD1   1 
ATOM   679  C  CD2   . LEU A 1 85  ? 128.050 95.168  128.362 1.00 54.58 ? 85  LEU A CD2   1 
ATOM   680  N  N     . PHE A 1 86  ? 129.028 92.974  125.564 1.00 51.99 ? 86  PHE A N     1 
ATOM   681  C  CA    . PHE A 1 86  ? 128.357 93.484  124.372 1.00 51.99 ? 86  PHE A CA    1 
ATOM   682  C  C     . PHE A 1 86  ? 127.659 92.369  123.604 1.00 51.99 ? 86  PHE A C     1 
ATOM   683  O  O     . PHE A 1 86  ? 126.558 92.568  123.078 1.00 51.99 ? 86  PHE A O     1 
ATOM   684  C  CB    . PHE A 1 86  ? 129.356 94.210  123.470 1.00 51.99 ? 86  PHE A CB    1 
ATOM   685  C  CG    . PHE A 1 86  ? 129.574 95.652  123.836 1.00 51.99 ? 86  PHE A CG    1 
ATOM   686  C  CD1   . PHE A 1 86  ? 128.509 96.531  123.895 1.00 51.99 ? 86  PHE A CD1   1 
ATOM   687  C  CD2   . PHE A 1 86  ? 130.843 96.131  124.101 1.00 51.99 ? 86  PHE A CD2   1 
ATOM   688  C  CE1   . PHE A 1 86  ? 128.707 97.857  124.224 1.00 51.99 ? 86  PHE A CE1   1 
ATOM   689  C  CE2   . PHE A 1 86  ? 131.043 97.458  124.429 1.00 51.99 ? 86  PHE A CE2   1 
ATOM   690  C  CZ    . PHE A 1 86  ? 129.975 98.319  124.491 1.00 51.99 ? 86  PHE A CZ    1 
ATOM   691  N  N     . LYS A 1 87  ? 128.287 91.193  123.515 1.00 58.96 ? 87  LYS A N     1 
ATOM   692  C  CA    . LYS A 1 87  ? 127.655 90.082  122.809 1.00 58.96 ? 87  LYS A CA    1 
ATOM   693  C  C     . LYS A 1 87  ? 126.385 89.630  123.519 1.00 58.96 ? 87  LYS A C     1 
ATOM   694  O  O     . LYS A 1 87  ? 125.346 89.425  122.880 1.00 58.96 ? 87  LYS A O     1 
ATOM   695  C  CB    . LYS A 1 87  ? 128.636 88.920  122.669 1.00 58.96 ? 87  LYS A CB    1 
ATOM   696  C  CG    . LYS A 1 87  ? 128.265 87.939  121.575 1.00 58.96 ? 87  LYS A CG    1 
ATOM   697  C  CD    . LYS A 1 87  ? 128.384 88.589  120.207 1.00 58.96 ? 87  LYS A CD    1 
ATOM   698  C  CE    . LYS A 1 87  ? 128.032 87.615  119.096 1.00 58.96 ? 87  LYS A CE    1 
ATOM   699  N  NZ    . LYS A 1 87  ? 128.208 88.226  117.750 1.00 58.96 ? 87  LYS A NZ    1 
ATOM   700  N  N     . GLY A 1 88  ? 126.443 89.481  124.837 1.00 59.19 ? 88  GLY A N     1 
ATOM   701  C  CA    . GLY A 1 88  ? 125.273 89.123  125.606 1.00 59.19 ? 88  GLY A CA    1 
ATOM   702  C  C     . GLY A 1 88  ? 124.940 87.646  125.529 1.00 59.19 ? 88  GLY A C     1 
ATOM   703  O  O     . GLY A 1 88  ? 125.721 86.813  125.066 1.00 59.19 ? 88  GLY A O     1 
ATOM   704  N  N     . GLY A 1 89  ? 123.740 87.327  126.003 1.00 60.26 ? 89  GLY A N     1 
ATOM   705  C  CA    . GLY A 1 89  ? 123.239 85.967  125.989 1.00 60.26 ? 89  GLY A CA    1 
ATOM   706  C  C     . GLY A 1 89  ? 123.401 85.279  127.331 1.00 60.26 ? 89  GLY A C     1 
ATOM   707  O  O     . GLY A 1 89  ? 123.670 85.896  128.365 1.00 60.26 ? 89  GLY A O     1 
ATOM   708  N  N     . ALA A 1 90  ? 123.218 83.960  127.292 1.00 62.85 ? 90  ALA A N     1 
ATOM   709  C  CA    . ALA A 1 90  ? 123.338 83.156  128.505 1.00 62.85 ? 90  ALA A CA    1 
ATOM   710  C  C     . ALA A 1 90  ? 124.710 83.248  129.171 1.00 62.85 ? 90  ALA A C     1 
ATOM   711  O  O     . ALA A 1 90  ? 124.751 83.305  130.412 1.00 62.85 ? 90  ALA A O     1 
ATOM   712  C  CB    . ALA A 1 90  ? 122.971 81.697  128.198 1.00 62.85 ? 90  ALA A CB    1 
ATOM   713  N  N     . PRO A 1 91  ? 125.842 83.240  128.452 1.00 62.21 ? 91  PRO A N     1 
ATOM   714  C  CA    . PRO A 1 91  ? 127.128 83.449  129.142 1.00 62.21 ? 91  PRO A CA    1 
ATOM   715  C  C     . PRO A 1 91  ? 127.188 84.744  129.936 1.00 62.21 ? 91  PRO A C     1 
ATOM   716  O  O     . PRO A 1 91  ? 127.822 84.778  130.997 1.00 62.21 ? 91  PRO A O     1 
ATOM   717  C  CB    . PRO A 1 91  ? 128.160 83.451  128.005 1.00 62.21 ? 91  PRO A CB    1 
ATOM   718  C  CG    . PRO A 1 91  ? 127.474 82.947  126.803 1.00 62.21 ? 91  PRO A CG    1 
ATOM   719  C  CD    . PRO A 1 91  ? 126.026 82.739  127.077 1.00 62.21 ? 91  PRO A CD    1 
ATOM   720  N  N     . SER A 1 92  ? 126.553 85.812  129.455 1.00 60.50 ? 92  SER A N     1 
ATOM   721  C  CA    . SER A 1 92  ? 126.533 87.070  130.188 1.00 60.50 ? 92  SER A CA    1 
ATOM   722  C  C     . SER A 1 92  ? 125.418 87.136  131.224 1.00 60.50 ? 92  SER A C     1 
ATOM   723  O  O     . SER A 1 92  ? 125.339 88.127  131.958 1.00 60.50 ? 92  SER A O     1 
ATOM   724  C  CB    . SER A 1 92  ? 126.389 88.243  129.219 1.00 60.50 ? 92  SER A CB    1 
ATOM   725  O  OG    . SER A 1 92  ? 125.090 88.275  128.658 1.00 60.50 ? 92  SER A OG    1 
ATOM   726  N  N     . SER A 1 93  ? 124.559 86.122  131.298 1.00 63.29 ? 93  SER A N     1 
ATOM   727  C  CA    . SER A 1 93  ? 123.445 86.112  132.236 1.00 63.29 ? 93  SER A CA    1 
ATOM   728  C  C     . SER A 1 93  ? 123.838 85.623  133.622 1.00 63.29 ? 93  SER A C     1 
ATOM   729  O  O     . SER A 1 93  ? 123.046 85.762  134.560 1.00 63.29 ? 93  SER A O     1 
ATOM   730  C  CB    . SER A 1 93  ? 122.306 85.243  131.694 1.00 63.29 ? 93  SER A CB    1 
ATOM   731  O  OG    . SER A 1 93  ? 122.676 83.875  131.676 1.00 63.29 ? 93  SER A OG    1 
ATOM   732  N  N     . SER A 1 94  ? 125.032 85.051  133.776 1.00 62.45 ? 94  SER A N     1 
ATOM   733  C  CA    . SER A 1 94  ? 125.516 84.601  135.073 1.00 62.45 ? 94  SER A CA    1 
ATOM   734  C  C     . SER A 1 94  ? 126.794 85.313  135.490 1.00 62.45 ? 94  SER A C     1 
ATOM   735  O  O     . SER A 1 94  ? 127.508 84.820  136.372 1.00 62.45 ? 94  SER A O     1 
ATOM   736  C  CB    . SER A 1 94  ? 125.739 83.086  135.065 1.00 62.45 ? 94  SER A CB    1 
ATOM   737  O  OG    . SER A 1 94  ? 126.240 82.640  136.313 1.00 62.45 ? 94  SER A OG    1 
ATOM   738  N  N     . CYS A 1 95  ? 127.104 86.457  134.884 1.00 59.41 ? 95  CYS A N     1 
ATOM   739  C  CA    . CYS A 1 95  ? 128.343 87.173  135.149 1.00 59.41 ? 95  CYS A CA    1 
ATOM   740  C  C     . CYS A 1 95  ? 128.093 88.565  135.720 1.00 59.41 ? 95  CYS A C     1 
ATOM   741  O  O     . CYS A 1 95  ? 128.740 89.533  135.316 1.00 59.41 ? 95  CYS A O     1 
ATOM   742  C  CB    . CYS A 1 95  ? 129.189 87.259  133.880 1.00 59.41 ? 95  CYS A CB    1 
ATOM   743  S  SG    . CYS A 1 95  ? 129.939 85.688  133.384 1.00 59.41 ? 95  CYS A SG    1 
ATOM   744  N  N     . TYR A 1 96  ? 127.161 88.678  136.664 1.00 56.41 ? 96  TYR A N     1 
ATOM   745  C  CA    . TYR A 1 96  ? 126.919 89.927  137.377 1.00 56.41 ? 96  TYR A CA    1 
ATOM   746  C  C     . TYR A 1 96  ? 127.925 90.172  138.494 1.00 56.41 ? 96  TYR A C     1 
ATOM   747  O  O     . TYR A 1 96  ? 127.681 91.026  139.353 1.00 56.41 ? 96  TYR A O     1 
ATOM   748  C  CB    . TYR A 1 96  ? 125.491 89.951  137.940 1.00 56.41 ? 96  TYR A CB    1 
ATOM   749  C  CG    . TYR A 1 96  ? 125.153 88.789  138.845 1.00 56.41 ? 96  TYR A CG    1 
ATOM   750  C  CD1   . TYR A 1 96  ? 124.646 87.608  138.326 1.00 56.41 ? 96  TYR A CD1   1 
ATOM   751  C  CD2   . TYR A 1 96  ? 125.338 88.873  140.216 1.00 56.41 ? 96  TYR A CD2   1 
ATOM   752  C  CE1   . TYR A 1 96  ? 124.334 86.544  139.144 1.00 56.41 ? 96  TYR A CE1   1 
ATOM   753  C  CE2   . TYR A 1 96  ? 125.030 87.813  141.042 1.00 56.41 ? 96  TYR A CE2   1 
ATOM   754  C  CZ    . TYR A 1 96  ? 124.528 86.651  140.501 1.00 56.41 ? 96  TYR A CZ    1 
ATOM   755  O  OH    . TYR A 1 96  ? 124.217 85.589  141.318 1.00 56.41 ? 96  TYR A OH    1 
ATOM   756  N  N     . SER A 1 97  ? 129.050 89.457  138.487 1.00 59.21 ? 97  SER A N     1 
ATOM   757  C  CA    . SER A 1 97  ? 130.014 89.508  139.577 1.00 59.21 ? 97  SER A CA    1 
ATOM   758  C  C     . SER A 1 97  ? 130.754 90.833  139.664 1.00 59.21 ? 97  SER A C     1 
ATOM   759  O  O     . SER A 1 97  ? 131.581 90.994  140.565 1.00 59.21 ? 97  SER A O     1 
ATOM   760  C  CB    . SER A 1 97  ? 131.023 88.373  139.427 1.00 59.21 ? 97  SER A CB    1 
ATOM   761  O  OG    . SER A 1 97  ? 131.578 88.362  138.125 1.00 59.21 ? 97  SER A OG    1 
ATOM   762  N  N     . LEU A 1 98  ? 130.485 91.777  138.760 1.00 58.71 ? 98  LEU A N     1 
ATOM   763  C  CA    . LEU A 1 98  ? 131.205 93.047  138.776 1.00 58.71 ? 98  LEU A CA    1 
ATOM   764  C  C     . LEU A 1 98  ? 130.927 93.845  140.044 1.00 58.71 ? 98  LEU A C     1 
ATOM   765  O  O     . LEU A 1 98  ? 131.721 94.718  140.410 1.00 58.71 ? 98  LEU A O     1 
ATOM   766  C  CB    . LEU A 1 98  ? 130.838 93.874  137.543 1.00 58.71 ? 98  LEU A CB    1 
ATOM   767  C  CG    . LEU A 1 98  ? 131.852 94.937  137.125 1.00 58.71 ? 98  LEU A CG    1 
ATOM   768  C  CD1   . LEU A 1 98  ? 133.093 94.267  136.584 1.00 58.71 ? 98  LEU A CD1   1 
ATOM   769  C  CD2   . LEU A 1 98  ? 131.265 95.882  136.099 1.00 58.71 ? 98  LEU A CD2   1 
ATOM   770  N  N     . PHE A 1 99  ? 129.807 93.576  140.720 1.00 54.79 ? 99  PHE A N     1 
ATOM   771  C  CA    . PHE A 1 99  ? 129.426 94.325  141.909 1.00 54.79 ? 99  PHE A CA    1 
ATOM   772  C  C     . PHE A 1 99  ? 129.069 93.464  143.112 1.00 54.79 ? 99  PHE A C     1 
ATOM   773  O  O     . PHE A 1 99  ? 129.301 93.900  144.243 1.00 54.79 ? 99  PHE A O     1 
ATOM   774  C  CB    . PHE A 1 99  ? 128.239 95.246  141.598 1.00 54.79 ? 99  PHE A CB    1 
ATOM   775  C  CG    . PHE A 1 99  ? 128.425 96.079  140.368 1.00 54.79 ? 99  PHE A CG    1 
ATOM   776  C  CD1   . PHE A 1 99  ? 129.500 96.935  140.255 1.00 54.79 ? 99  PHE A CD1   1 
ATOM   777  C  CD2   . PHE A 1 99  ? 127.530 95.998  139.321 1.00 54.79 ? 99  PHE A CD2   1 
ATOM   778  C  CE1   . PHE A 1 99  ? 129.671 97.700  139.127 1.00 54.79 ? 99  PHE A CE1   1 
ATOM   779  C  CE2   . PHE A 1 99  ? 127.698 96.760  138.192 1.00 54.79 ? 99  PHE A CE2   1 
ATOM   780  C  CZ    . PHE A 1 99  ? 128.769 97.612  138.094 1.00 54.79 ? 99  PHE A CZ    1 
ATOM   781  N  N     . TYR A 1 100 ? 128.522 92.270  142.911 1.00 65.10 ? 100 TYR A N     1 
ATOM   782  C  CA    . TYR A 1 100 ? 128.130 91.403  144.014 1.00 65.10 ? 100 TYR A CA    1 
ATOM   783  C  C     . TYR A 1 100 ? 129.377 90.790  144.639 1.00 65.10 ? 100 TYR A C     1 
ATOM   784  O  O     . TYR A 1 100 ? 130.197 90.193  143.934 1.00 65.10 ? 100 TYR A O     1 
ATOM   785  C  CB    . TYR A 1 100 ? 127.177 90.312  143.528 1.00 65.10 ? 100 TYR A CB    1 
ATOM   786  C  CG    . TYR A 1 100 ? 126.565 89.488  144.636 1.00 65.10 ? 100 TYR A CG    1 
ATOM   787  C  CD1   . TYR A 1 100 ? 125.979 90.094  145.737 1.00 65.10 ? 100 TYR A CD1   1 
ATOM   788  C  CD2   . TYR A 1 100 ? 126.574 88.103  144.580 1.00 65.10 ? 100 TYR A CD2   1 
ATOM   789  C  CE1   . TYR A 1 100 ? 125.419 89.345  146.749 1.00 65.10 ? 100 TYR A CE1   1 
ATOM   790  C  CE2   . TYR A 1 100 ? 126.017 87.345  145.586 1.00 65.10 ? 100 TYR A CE2   1 
ATOM   791  C  CZ    . TYR A 1 100 ? 125.441 87.969  146.669 1.00 65.10 ? 100 TYR A CZ    1 
ATOM   792  O  OH    . TYR A 1 100 ? 124.885 87.213  147.676 1.00 65.10 ? 100 TYR A OH    1 
ATOM   793  N  N     . GLU A 1 101 ? 129.517 90.930  145.960 1.00 70.43 ? 101 GLU A N     1 
ATOM   794  C  CA    . GLU A 1 101 ? 130.714 90.439  146.631 1.00 70.43 ? 101 GLU A CA    1 
ATOM   795  C  C     . GLU A 1 101 ? 130.821 88.921  146.618 1.00 70.43 ? 101 GLU A C     1 
ATOM   796  O  O     . GLU A 1 101 ? 131.902 88.393  146.899 1.00 70.43 ? 101 GLU A O     1 
ATOM   797  C  CB    . GLU A 1 101 ? 130.763 90.916  148.083 1.00 70.43 ? 101 GLU A CB    1 
ATOM   798  C  CG    . GLU A 1 101 ? 129.745 90.235  148.983 1.00 70.43 ? 101 GLU A CG    1 
ATOM   799  C  CD    . GLU A 1 101 ? 129.877 90.645  150.437 1.00 70.43 ? 101 GLU A CD    1 
ATOM   800  O  OE1   . GLU A 1 101 ? 130.743 91.490  150.749 1.00 70.43 ? 101 GLU A OE1   1 
ATOM   801  O  OE2   . GLU A 1 101 ? 129.127 90.100  151.273 1.00 70.43 ? 101 GLU A OE2   1 
ATOM   802  N  N     . ASP A 1 102 ? 129.740 88.210  146.313 1.00 69.92 ? 102 ASP A N     1 
ATOM   803  C  CA    . ASP A 1 102 ? 129.762 86.754  146.340 1.00 69.92 ? 102 ASP A CA    1 
ATOM   804  C  C     . ASP A 1 102 ? 129.315 86.165  145.005 1.00 69.92 ? 102 ASP A C     1 
ATOM   805  O  O     . ASP A 1 102 ? 129.679 86.666  143.941 1.00 69.92 ? 102 ASP A O     1 
ATOM   806  C  CB    . ASP A 1 102 ? 128.874 86.232  147.471 1.00 69.92 ? 102 ASP A CB    1 
ATOM   807  C  CG    . ASP A 1 102 ? 129.420 86.574  148.842 1.00 69.92 ? 102 ASP A CG    1 
ATOM   808  O  OD1   . ASP A 1 102 ? 130.652 86.733  148.971 1.00 69.92 ? 102 ASP A OD1   1 
ATOM   809  O  OD2   . ASP A 1 102 ? 128.618 86.685  149.792 1.00 69.92 ? 102 ASP A OD2   1 
ATOM   810  N  N     . SER A 1 174 ? 132.480 85.125  135.023 1.00 69.03 ? 174 SER A N     1 
ATOM   811  C  CA    . SER A 1 174 ? 133.465 85.143  136.099 1.00 69.03 ? 174 SER A CA    1 
ATOM   812  C  C     . SER A 1 174 ? 134.559 86.167  135.824 1.00 69.03 ? 174 SER A C     1 
ATOM   813  O  O     . SER A 1 174 ? 135.384 86.451  136.691 1.00 69.03 ? 174 SER A O     1 
ATOM   814  C  CB    . SER A 1 174 ? 134.082 83.755  136.284 1.00 69.03 ? 174 SER A CB    1 
ATOM   815  O  OG    . SER A 1 174 ? 134.965 83.444  135.221 1.00 69.03 ? 174 SER A OG    1 
ATOM   816  N  N     . LEU A 1 175 ? 134.554 86.720  134.609 1.00 69.20 ? 175 LEU A N     1 
ATOM   817  C  CA    . LEU A 1 175 ? 135.584 87.680  134.226 1.00 69.20 ? 175 LEU A CA    1 
ATOM   818  C  C     . LEU A 1 175 ? 135.518 88.947  135.068 1.00 69.20 ? 175 LEU A C     1 
ATOM   819  O  O     . LEU A 1 175 ? 136.559 89.508  135.425 1.00 69.20 ? 175 LEU A O     1 
ATOM   820  C  CB    . LEU A 1 175 ? 135.461 88.023  132.742 1.00 69.20 ? 175 LEU A CB    1 
ATOM   821  C  CG    . LEU A 1 175 ? 135.876 86.926  131.762 1.00 69.20 ? 175 LEU A CG    1 
ATOM   822  C  CD1   . LEU A 1 175 ? 135.622 87.364  130.332 1.00 69.20 ? 175 LEU A CD1   1 
ATOM   823  C  CD2   . LEU A 1 175 ? 137.337 86.558  131.961 1.00 69.20 ? 175 LEU A CD2   1 
ATOM   824  N  N     . GLY A 1 176 ? 134.312 89.411  135.399 1.00 66.35 ? 176 GLY A N     1 
ATOM   825  C  CA    . GLY A 1 176 ? 134.189 90.606  136.213 1.00 66.35 ? 176 GLY A CA    1 
ATOM   826  C  C     . GLY A 1 176 ? 134.570 90.401  137.662 1.00 66.35 ? 176 GLY A C     1 
ATOM   827  O  O     . GLY A 1 176 ? 134.714 91.382  138.399 1.00 66.35 ? 176 GLY A O     1 
ATOM   828  N  N     . LYS A 1 177 ? 134.730 89.148  138.090 1.00 69.02 ? 177 LYS A N     1 
ATOM   829  C  CA    . LYS A 1 177 ? 135.120 88.883  139.470 1.00 69.02 ? 177 LYS A CA    1 
ATOM   830  C  C     . LYS A 1 177 ? 136.585 89.227  139.710 1.00 69.02 ? 177 LYS A C     1 
ATOM   831  O  O     . LYS A 1 177 ? 136.926 89.848  140.723 1.00 69.02 ? 177 LYS A O     1 
ATOM   832  C  CB    . LYS A 1 177 ? 134.846 87.423  139.822 1.00 69.02 ? 177 LYS A CB    1 
ATOM   833  C  CG    . LYS A 1 177 ? 135.144 87.073  141.270 1.00 69.02 ? 177 LYS A CG    1 
ATOM   834  C  CD    . LYS A 1 177 ? 135.440 85.591  141.434 1.00 69.02 ? 177 LYS A CD    1 
ATOM   835  C  CE    . LYS A 1 177 ? 134.222 84.836  141.938 1.00 69.02 ? 177 LYS A CE    1 
ATOM   836  N  NZ    . LYS A 1 177 ? 134.601 83.710  142.837 1.00 69.02 ? 177 LYS A NZ    1 
ATOM   837  N  N     . GLN A 1 178 ? 137.472 88.830  138.791 1.00 71.49 ? 178 GLN A N     1 
ATOM   838  C  CA    . GLN A 1 178 ? 138.899 88.990  139.053 1.00 71.49 ? 178 GLN A CA    1 
ATOM   839  C  C     . GLN A 1 178 ? 139.373 90.428  138.873 1.00 71.49 ? 178 GLN A C     1 
ATOM   840  O  O     . GLN A 1 178 ? 140.336 90.836  139.531 1.00 71.49 ? 178 GLN A O     1 
ATOM   841  C  CB    . GLN A 1 178 ? 139.732 88.055  138.171 1.00 71.49 ? 178 GLN A CB    1 
ATOM   842  C  CG    . GLN A 1 178 ? 139.908 88.491  136.724 1.00 71.49 ? 178 GLN A CG    1 
ATOM   843  C  CD    . GLN A 1 178 ? 138.992 87.751  135.774 1.00 71.49 ? 178 GLN A CD    1 
ATOM   844  O  OE1   . GLN A 1 178 ? 138.031 87.112  136.195 1.00 71.49 ? 178 GLN A OE1   1 
ATOM   845  N  NE2   . GLN A 1 178 ? 139.291 87.828  134.482 1.00 71.49 ? 178 GLN A NE2   1 
ATOM   846  N  N     . LEU A 1 179 ? 138.732 91.212  138.000 1.00 69.93 ? 179 LEU A N     1 
ATOM   847  C  CA    . LEU A 1 179 ? 139.188 92.586  137.828 1.00 69.93 ? 179 LEU A CA    1 
ATOM   848  C  C     . LEU A 1 179 ? 138.801 93.464  139.009 1.00 69.93 ? 179 LEU A C     1 
ATOM   849  O  O     . LEU A 1 179 ? 139.386 94.538  139.184 1.00 69.93 ? 179 LEU A O     1 
ATOM   850  C  CB    . LEU A 1 179 ? 138.657 93.184  136.521 1.00 69.93 ? 179 LEU A CB    1 
ATOM   851  C  CG    . LEU A 1 179 ? 137.166 93.354  136.234 1.00 69.93 ? 179 LEU A CG    1 
ATOM   852  C  CD1   . LEU A 1 179 ? 136.636 94.637  136.854 1.00 69.93 ? 179 LEU A CD1   1 
ATOM   853  C  CD2   . LEU A 1 179 ? 136.920 93.351  134.733 1.00 69.93 ? 179 LEU A CD2   1 
ATOM   854  N  N     . ARG A 1 180 ? 137.827 93.038  139.817 1.00 71.30 ? 180 ARG A N     1 
ATOM   855  C  CA    . ARG A 1 180 ? 137.553 93.741  141.065 1.00 71.30 ? 180 ARG A CA    1 
ATOM   856  C  C     . ARG A 1 180 ? 138.752 93.677  142.000 1.00 71.30 ? 180 ARG A C     1 
ATOM   857  O  O     . ARG A 1 180 ? 139.104 94.673  142.641 1.00 71.30 ? 180 ARG A O     1 
ATOM   858  C  CB    . ARG A 1 180 ? 136.318 93.159  141.749 1.00 71.30 ? 180 ARG A CB    1 
ATOM   859  C  CG    . ARG A 1 180 ? 135.001 93.558  141.119 1.00 71.30 ? 180 ARG A CG    1 
ATOM   860  C  CD    . ARG A 1 180 ? 133.861 92.723  141.673 1.00 71.30 ? 180 ARG A CD    1 
ATOM   861  N  NE    . ARG A 1 180 ? 133.806 92.767  143.128 1.00 71.30 ? 180 ARG A NE    1 
ATOM   862  C  CZ    . ARG A 1 180 ? 133.868 91.699  143.910 1.00 71.30 ? 180 ARG A CZ    1 
ATOM   863  N  NH1   . ARG A 1 180 ? 133.957 90.479  143.407 1.00 71.30 ? 180 ARG A NH1   1 
ATOM   864  N  NH2   . ARG A 1 180 ? 133.840 91.857  145.229 1.00 71.30 ? 180 ARG A NH2   1 
ATOM   865  N  N     . GLU A 1 181 ? 139.393 92.513  142.088 1.00 78.74 ? 181 GLU A N     1 
ATOM   866  C  CA    . GLU A 1 181 ? 140.579 92.372  142.921 1.00 78.74 ? 181 GLU A CA    1 
ATOM   867  C  C     . GLU A 1 181 ? 141.780 93.126  142.366 1.00 78.74 ? 181 GLU A C     1 
ATOM   868  O  O     . GLU A 1 181 ? 142.784 93.261  143.073 1.00 78.74 ? 181 GLU A O     1 
ATOM   869  C  CB    . GLU A 1 181 ? 140.921 90.891  143.089 1.00 78.74 ? 181 GLU A CB    1 
ATOM   870  C  CG    . GLU A 1 181 ? 139.900 90.123  143.914 1.00 78.74 ? 181 GLU A CG    1 
ATOM   871  C  CD    . GLU A 1 181 ? 139.984 88.624  143.704 1.00 78.74 ? 181 GLU A CD    1 
ATOM   872  O  OE1   . GLU A 1 181 ? 140.539 88.197  142.670 1.00 78.74 ? 181 GLU A OE1   1 
ATOM   873  O  OE2   . GLU A 1 181 ? 139.492 87.873  144.573 1.00 78.74 ? 181 GLU A OE2   1 
ATOM   874  N  N     . ARG A 1 182 ? 141.704 93.615  141.129 1.00 75.80 ? 182 ARG A N     1 
ATOM   875  C  CA    . ARG A 1 182 ? 142.791 94.375  140.526 1.00 75.80 ? 182 ARG A CA    1 
ATOM   876  C  C     . ARG A 1 182 ? 142.542 95.878  140.518 1.00 75.80 ? 182 ARG A C     1 
ATOM   877  O  O     . ARG A 1 182 ? 143.504 96.652  140.526 1.00 75.80 ? 182 ARG A O     1 
ATOM   878  C  CB    . ARG A 1 182 ? 143.040 93.893  139.093 1.00 75.80 ? 182 ARG A CB    1 
ATOM   879  C  CG    . ARG A 1 182 ? 144.388 94.304  138.525 1.00 75.80 ? 182 ARG A CG    1 
ATOM   880  C  CD    . ARG A 1 182 ? 144.752 93.463  137.315 1.00 75.80 ? 182 ARG A CD    1 
ATOM   881  N  NE    . ARG A 1 182 ? 144.913 92.056  137.663 1.00 75.80 ? 182 ARG A NE    1 
ATOM   882  C  CZ    . ARG A 1 182 ? 144.992 91.071  136.780 1.00 75.80 ? 182 ARG A CZ    1 
ATOM   883  N  NH1   . ARG A 1 182 ? 144.932 91.302  135.479 1.00 75.80 ? 182 ARG A NH1   1 
ATOM   884  N  NH2   . ARG A 1 182 ? 145.134 89.822  137.213 1.00 75.80 ? 182 ARG A NH2   1 
ATOM   885  N  N     . LEU A 1 183 ? 141.280 96.310  140.498 1.00 70.40 ? 183 LEU A N     1 
ATOM   886  C  CA    . LEU A 1 183 ? 140.953 97.728  140.546 1.00 70.40 ? 183 LEU A CA    1 
ATOM   887  C  C     . LEU A 1 183 ? 140.275 98.163  141.836 1.00 70.40 ? 183 LEU A C     1 
ATOM   888  O  O     . LEU A 1 183 ? 140.261 99.362  142.129 1.00 70.40 ? 183 LEU A O     1 
ATOM   889  C  CB    . LEU A 1 183 ? 140.051 98.115  139.365 1.00 70.40 ? 183 LEU A CB    1 
ATOM   890  C  CG    . LEU A 1 183 ? 140.740 98.468  138.046 1.00 70.40 ? 183 LEU A CG    1 
ATOM   891  C  CD1   . LEU A 1 183 ? 141.253 97.226  137.340 1.00 70.40 ? 183 LEU A CD1   1 
ATOM   892  C  CD2   . LEU A 1 183 ? 139.791 99.247  137.148 1.00 70.40 ? 183 LEU A CD2   1 
ATOM   893  N  N     . GLY A 1 184 ? 139.720 97.235  142.608 1.00 67.07 ? 184 GLY A N     1 
ATOM   894  C  CA    . GLY A 1 184 ? 139.071 97.593  143.858 1.00 67.07 ? 184 GLY A CA    1 
ATOM   895  C  C     . GLY A 1 184 ? 137.816 98.424  143.706 1.00 67.07 ? 184 GLY A C     1 
ATOM   896  O  O     . GLY A 1 184 ? 137.635 99.404  144.439 1.00 67.07 ? 184 GLY A O     1 
ATOM   897  N  N     . ILE A 1 185 ? 136.945 98.062  142.770 1.00 61.75 ? 185 ILE A N     1 
ATOM   898  C  CA    . ILE A 1 185 ? 135.703 98.790  142.535 1.00 61.75 ? 185 ILE A CA    1 
ATOM   899  C  C     . ILE A 1 185 ? 134.593 98.180  143.382 1.00 61.75 ? 185 ILE A C     1 
ATOM   900  O  O     . ILE A 1 185 ? 134.452 96.954  143.458 1.00 61.75 ? 185 ILE A O     1 
ATOM   901  C  CB    . ILE A 1 185 ? 135.340 98.790  141.040 1.00 61.75 ? 185 ILE A CB    1 
ATOM   902  C  CG1   . ILE A 1 185 ? 135.110 97.368  140.526 1.00 61.75 ? 185 ILE A CG1   1 
ATOM   903  C  CG2   . ILE A 1 185 ? 136.421 99.479  140.227 1.00 61.75 ? 185 ILE A CG2   1 
ATOM   904  C  CD1   . ILE A 1 185 ? 134.529 97.313  139.134 1.00 61.75 ? 185 ILE A CD1   1 
ATOM   905  N  N     . LYS A 1 186 ? 133.821 99.039  144.046 1.00 56.90 ? 186 LYS A N     1 
ATOM   906  C  CA    . LYS A 1 186 ? 132.722 98.613  144.899 1.00 56.90 ? 186 LYS A CA    1 
ATOM   907  C  C     . LYS A 1 186 ? 131.517 99.517  144.679 1.00 56.90 ? 186 LYS A C     1 
ATOM   908  O  O     . LYS A 1 186 ? 131.657 100.689 144.320 1.00 56.90 ? 186 LYS A O     1 
ATOM   909  C  CB    . LYS A 1 186 ? 133.121 98.630  146.379 1.00 56.90 ? 186 LYS A CB    1 
ATOM   910  C  CG    . LYS A 1 186 ? 133.391 100.019 146.928 1.00 56.90 ? 186 LYS A CG    1 
ATOM   911  C  CD    . LYS A 1 186 ? 133.829 99.965  148.380 1.00 56.90 ? 186 LYS A CD    1 
ATOM   912  C  CE    . LYS A 1 186 ? 132.684 99.547  149.287 1.00 56.90 ? 186 LYS A CE    1 
ATOM   913  N  NZ    . LYS A 1 186 ? 131.600 100.568 149.318 1.00 56.90 ? 186 LYS A NZ    1 
ATOM   914  N  N     . CYS A 1 187 ? 130.331 98.959  144.898 1.00 53.01 ? 187 CYS A N     1 
ATOM   915  C  CA    . CYS A 1 187 ? 129.083 99.693  144.757 1.00 53.01 ? 187 CYS A CA    1 
ATOM   916  C  C     . CYS A 1 187 ? 128.512 100.051 146.127 1.00 53.01 ? 187 CYS A C     1 
ATOM   917  O  O     . CYS A 1 187 ? 129.083 99.732  147.172 1.00 53.01 ? 187 CYS A O     1 
ATOM   918  C  CB    . CYS A 1 187 ? 128.070 98.882  143.944 1.00 53.01 ? 187 CYS A CB    1 
ATOM   919  S  SG    . CYS A 1 187 ? 127.739 97.234  144.591 1.00 53.01 ? 187 CYS A SG    1 
ATOM   920  N  N     . ARG A 1 188 ? 127.366 100.736 146.107 1.00 46.08 ? 188 ARG A N     1 
ATOM   921  C  CA    . ARG A 1 188 ? 126.757 101.196 147.352 1.00 46.08 ? 188 ARG A CA    1 
ATOM   922  C  C     . ARG A 1 188 ? 126.296 100.029 148.216 1.00 46.08 ? 188 ARG A C     1 
ATOM   923  O  O     . ARG A 1 188 ? 126.457 100.054 149.441 1.00 46.08 ? 188 ARG A O     1 
ATOM   924  C  CB    . ARG A 1 188 ? 125.593 102.137 147.051 1.00 46.08 ? 188 ARG A CB    1 
ATOM   925  C  CG    . ARG A 1 188 ? 126.028 103.540 146.688 1.00 46.08 ? 188 ARG A CG    1 
ATOM   926  C  CD    . ARG A 1 188 ? 124.872 104.343 146.151 1.00 46.08 ? 188 ARG A CD    1 
ATOM   927  N  NE    . ARG A 1 188 ? 125.280 105.661 145.684 1.00 46.08 ? 188 ARG A NE    1 
ATOM   928  C  CZ    . ARG A 1 188 ? 125.044 106.791 146.336 1.00 46.08 ? 188 ARG A CZ    1 
ATOM   929  N  NH1   . ARG A 1 188 ? 124.440 106.798 147.512 1.00 46.08 ? 188 ARG A NH1   1 
ATOM   930  N  NH2   . ARG A 1 188 ? 125.422 107.945 145.792 1.00 46.08 ? 188 ARG A NH2   1 
ATOM   931  N  N     . ARG A 1 189 ? 125.719 99.000  147.601 1.00 46.90 ? 189 ARG A N     1 
ATOM   932  C  CA    . ARG A 1 189 ? 125.231 97.820  148.313 1.00 46.90 ? 189 ARG A CA    1 
ATOM   933  C  C     . ARG A 1 189 ? 125.843 96.583  147.675 1.00 46.90 ? 189 ARG A C     1 
ATOM   934  O  O     . ARG A 1 189 ? 125.190 95.890  146.885 1.00 46.90 ? 189 ARG A O     1 
ATOM   935  C  CB    . ARG A 1 189 ? 123.705 97.742  148.291 1.00 46.90 ? 189 ARG A CB    1 
ATOM   936  C  CG    . ARG A 1 189 ? 123.006 99.066  148.508 1.00 46.90 ? 189 ARG A CG    1 
ATOM   937  C  CD    . ARG A 1 189 ? 121.526 98.864  148.770 1.00 46.90 ? 189 ARG A CD    1 
ATOM   938  N  NE    . ARG A 1 189 ? 120.786 100.117 148.702 1.00 46.90 ? 189 ARG A NE    1 
ATOM   939  C  CZ    . ARG A 1 189 ? 119.592 100.312 149.244 1.00 46.90 ? 189 ARG A CZ    1 
ATOM   940  N  NH1   . ARG A 1 189 ? 118.971 99.353  149.911 1.00 46.90 ? 189 ARG A NH1   1 
ATOM   941  N  NH2   . ARG A 1 189 ? 119.004 101.497 149.109 1.00 46.90 ? 189 ARG A NH2   1 
ATOM   942  N  N     . PRO A 1 190 ? 127.099 96.273  147.994 1.00 57.42 ? 190 PRO A N     1 
ATOM   943  C  CA    . PRO A 1 190 ? 127.730 95.061  147.465 1.00 57.42 ? 190 PRO A CA    1 
ATOM   944  C  C     . PRO A 1 190 ? 127.254 93.769  148.110 1.00 57.42 ? 190 PRO A C     1 
ATOM   945  O  O     . PRO A 1 190 ? 127.808 92.710  147.806 1.00 57.42 ? 190 PRO A O     1 
ATOM   946  C  CB    . PRO A 1 190 ? 129.217 95.300  147.764 1.00 57.42 ? 190 PRO A CB    1 
ATOM   947  C  CG    . PRO A 1 190 ? 129.219 96.149  148.973 1.00 57.42 ? 190 PRO A CG    1 
ATOM   948  C  CD    . PRO A 1 190 ? 127.995 97.020  148.894 1.00 57.42 ? 190 PRO A CD    1 
ATOM   949  N  N     . HIS A 1 191 ? 126.252 93.826  148.984 1.00 63.34 ? 191 HIS A N     1 
ATOM   950  C  CA    . HIS A 1 191 ? 125.772 92.660  149.711 1.00 63.34 ? 191 HIS A CA    1 
ATOM   951  C  C     . HIS A 1 191 ? 124.397 92.198  149.246 1.00 63.34 ? 191 HIS A C     1 
ATOM   952  O  O     . HIS A 1 191 ? 123.891 91.192  149.751 1.00 63.34 ? 191 HIS A O     1 
ATOM   953  C  CB    . HIS A 1 191 ? 125.740 92.965  151.207 1.00 63.34 ? 191 HIS A CB    1 
ATOM   954  C  CG    . HIS A 1 191 ? 127.078 93.313  151.778 1.00 63.34 ? 191 HIS A CG    1 
ATOM   955  N  ND1   . HIS A 1 191 ? 127.592 94.591  151.740 1.00 63.34 ? 191 HIS A ND1   1 
ATOM   956  C  CD2   . HIS A 1 191 ? 128.004 92.555  152.410 1.00 63.34 ? 191 HIS A CD2   1 
ATOM   957  C  CE1   . HIS A 1 191 ? 128.780 94.603  152.316 1.00 63.34 ? 191 HIS A CE1   1 
ATOM   958  N  NE2   . HIS A 1 191 ? 129.054 93.380  152.731 1.00 63.34 ? 191 HIS A NE2   1 
ATOM   959  N  N     . ASP A 1 192 ? 123.785 92.902  148.300 1.00 58.52 ? 192 ASP A N     1 
ATOM   960  C  CA    . ASP A 1 192 ? 122.441 92.600  147.829 1.00 58.52 ? 192 ASP A CA    1 
ATOM   961  C  C     . ASP A 1 192 ? 122.520 92.063  146.408 1.00 58.52 ? 192 ASP A C     1 
ATOM   962  O  O     . ASP A 1 192 ? 122.818 92.815  145.475 1.00 58.52 ? 192 ASP A O     1 
ATOM   963  C  CB    . ASP A 1 192 ? 121.557 93.849  147.884 1.00 58.52 ? 192 ASP A CB    1 
ATOM   964  C  CG    . ASP A 1 192 ? 120.085 93.534  147.713 1.00 58.52 ? 192 ASP A CG    1 
ATOM   965  O  OD1   . ASP A 1 192 ? 119.731 92.339  147.642 1.00 58.52 ? 192 ASP A OD1   1 
ATOM   966  O  OD2   . ASP A 1 192 ? 119.279 94.486  147.658 1.00 58.52 ? 192 ASP A OD2   1 
ATOM   967  N  N     . ALA A 1 193 ? 122.240 90.767  146.247 1.00 54.54 ? 193 ALA A N     1 
ATOM   968  C  CA    . ALA A 1 193 ? 122.401 90.126  144.944 1.00 54.54 ? 193 ALA A CA    1 
ATOM   969  C  C     . ALA A 1 193 ? 121.478 90.745  143.904 1.00 54.54 ? 193 ALA A C     1 
ATOM   970  O  O     . ALA A 1 193 ? 121.888 90.993  142.764 1.00 54.54 ? 193 ALA A O     1 
ATOM   971  C  CB    . ALA A 1 193 ? 122.146 88.624  145.063 1.00 54.54 ? 193 ALA A CB    1 
ATOM   972  N  N     . GLY A 1 194 ? 120.225 91.002  144.277 1.00 49.45 ? 194 GLY A N     1 
ATOM   973  C  CA    . GLY A 1 194 ? 119.306 91.623  143.341 1.00 49.45 ? 194 GLY A CA    1 
ATOM   974  C  C     . GLY A 1 194 ? 119.743 93.018  142.944 1.00 49.45 ? 194 GLY A C     1 
ATOM   975  O  O     . GLY A 1 194 ? 119.658 93.397  141.773 1.00 49.45 ? 194 GLY A O     1 
ATOM   976  N  N     . TYR A 1 195 ? 120.220 93.800  143.912 1.00 46.68 ? 195 TYR A N     1 
ATOM   977  C  CA    . TYR A 1 195 ? 120.678 95.151  143.614 1.00 46.68 ? 195 TYR A CA    1 
ATOM   978  C  C     . TYR A 1 195 ? 121.758 95.130  142.538 1.00 46.68 ? 195 TYR A C     1 
ATOM   979  O  O     . TYR A 1 195 ? 121.674 95.854  141.538 1.00 46.68 ? 195 TYR A O     1 
ATOM   980  C  CB    . TYR A 1 195 ? 121.183 95.808  144.898 1.00 46.68 ? 195 TYR A CB    1 
ATOM   981  C  CG    . TYR A 1 195 ? 121.713 97.205  144.729 1.00 46.68 ? 195 TYR A CG    1 
ATOM   982  C  CD1   . TYR A 1 195 ? 123.056 97.429  144.470 1.00 46.68 ? 195 TYR A CD1   1 
ATOM   983  C  CD2   . TYR A 1 195 ? 120.874 98.299  144.833 1.00 46.68 ? 195 TYR A CD2   1 
ATOM   984  C  CE1   . TYR A 1 195 ? 123.546 98.700  144.316 1.00 46.68 ? 195 TYR A CE1   1 
ATOM   985  C  CE2   . TYR A 1 195 ? 121.356 99.578  144.681 1.00 46.68 ? 195 TYR A CE2   1 
ATOM   986  C  CZ    . TYR A 1 195 ? 122.693 99.772  144.422 1.00 46.68 ? 195 TYR A CZ    1 
ATOM   987  O  OH    . TYR A 1 195 ? 123.185 101.044 144.267 1.00 46.68 ? 195 TYR A OH    1 
ATOM   988  N  N     . CYS A 1 196 ? 122.758 94.262  142.704 1.00 47.70 ? 196 CYS A N     1 
ATOM   989  C  CA    . CYS A 1 196 ? 123.827 94.150  141.719 1.00 47.70 ? 196 CYS A CA    1 
ATOM   990  C  C     . CYS A 1 196 ? 123.310 93.609  140.391 1.00 47.70 ? 196 CYS A C     1 
ATOM   991  O  O     . CYS A 1 196 ? 123.781 94.018  139.322 1.00 47.70 ? 196 CYS A O     1 
ATOM   992  C  CB    . CYS A 1 196 ? 124.937 93.263  142.273 1.00 47.70 ? 196 CYS A CB    1 
ATOM   993  S  SG    . CYS A 1 196 ? 125.673 93.907  143.787 1.00 47.70 ? 196 CYS A SG    1 
ATOM   994  N  N     . LYS A 1 197 ? 122.351 92.679  140.437 1.00 45.95 ? 197 LYS A N     1 
ATOM   995  C  CA    . LYS A 1 197 ? 121.802 92.117  139.206 1.00 45.95 ? 197 LYS A CA    1 
ATOM   996  C  C     . LYS A 1 197 ? 121.156 93.197  138.349 1.00 45.95 ? 197 LYS A C     1 
ATOM   997  O  O     . LYS A 1 197 ? 121.502 93.365  137.171 1.00 45.95 ? 197 LYS A O     1 
ATOM   998  C  CB    . LYS A 1 197 ? 120.789 91.024  139.542 1.00 45.95 ? 197 LYS A CB    1 
ATOM   999  C  CG    . LYS A 1 197 ? 121.335 89.619  139.435 1.00 45.95 ? 197 LYS A CG    1 
ATOM   1000 C  CD    . LYS A 1 197 ? 120.263 88.593  139.734 1.00 45.95 ? 197 LYS A CD    1 
ATOM   1001 C  CE    . LYS A 1 197 ? 120.761 87.184  139.468 1.00 45.95 ? 197 LYS A CE    1 
ATOM   1002 N  NZ    . LYS A 1 197 ? 119.645 86.210  139.316 1.00 45.95 ? 197 LYS A NZ    1 
ATOM   1003 N  N     . ILE A 1 198 ? 120.228 93.957  138.931 1.00 38.86 ? 198 ILE A N     1 
ATOM   1004 C  CA    . ILE A 1 198 ? 119.636 95.064  138.184 1.00 38.86 ? 198 ILE A CA    1 
ATOM   1005 C  C     . ILE A 1 198 ? 120.690 96.092  137.794 1.00 38.86 ? 198 ILE A C     1 
ATOM   1006 O  O     . ILE A 1 198 ? 120.620 96.676  136.707 1.00 38.86 ? 198 ILE A O     1 
ATOM   1007 C  CB    . ILE A 1 198 ? 118.454 95.712  138.936 1.00 38.86 ? 198 ILE A CB    1 
ATOM   1008 C  CG1   . ILE A 1 198 ? 117.269 94.749  139.123 1.00 38.86 ? 198 ILE A CG1   1 
ATOM   1009 C  CG2   . ILE A 1 198 ? 118.012 96.972  138.244 1.00 38.86 ? 198 ILE A CG2   1 
ATOM   1010 C  CD1   . ILE A 1 198 ? 117.253 93.906  140.332 1.00 38.86 ? 198 ILE A CD1   1 
ATOM   1011 N  N     . LEU A 1 199 ? 121.683 96.334  138.657 1.00 39.72 ? 199 LEU A N     1 
ATOM   1012 C  CA    . LEU A 1 199 ? 122.682 97.350  138.329 1.00 39.72 ? 199 LEU A CA    1 
ATOM   1013 C  C     . LEU A 1 199 ? 123.444 96.992  137.057 1.00 39.72 ? 199 LEU A C     1 
ATOM   1014 O  O     . LEU A 1 199 ? 123.562 97.817  136.137 1.00 39.72 ? 199 LEU A O     1 
ATOM   1015 C  CB    . LEU A 1 199 ? 123.641 97.541  139.504 1.00 39.72 ? 199 LEU A CB    1 
ATOM   1016 C  CG    . LEU A 1 199 ? 124.656 98.678  139.369 1.00 39.72 ? 199 LEU A CG    1 
ATOM   1017 C  CD1   . LEU A 1 199 ? 123.945 100.008 139.247 1.00 39.72 ? 199 LEU A CD1   1 
ATOM   1018 C  CD2   . LEU A 1 199 ? 125.592 98.692  140.561 1.00 39.72 ? 199 LEU A CD2   1 
ATOM   1019 N  N     . MET A 1 200 ? 123.941 95.757  136.967 1.00 41.71 ? 200 MET A N     1 
ATOM   1020 C  CA    . MET A 1 200 ? 124.688 95.381  135.773 1.00 41.71 ? 200 MET A CA    1 
ATOM   1021 C  C     . MET A 1 200 ? 123.769 95.238  134.565 1.00 41.71 ? 200 MET A C     1 
ATOM   1022 O  O     . MET A 1 200 ? 124.191 95.495  133.433 1.00 41.71 ? 200 MET A O     1 
ATOM   1023 C  CB    . MET A 1 200 ? 125.487 94.101  135.998 1.00 41.71 ? 200 MET A CB    1 
ATOM   1024 C  CG    . MET A 1 200 ? 126.335 93.748  134.784 1.00 41.71 ? 200 MET A CG    1 
ATOM   1025 S  SD    . MET A 1 200 ? 127.392 92.310  134.967 1.00 41.71 ? 200 MET A SD    1 
ATOM   1026 C  CE    . MET A 1 200 ? 128.099 92.195  133.326 1.00 41.71 ? 200 MET A CE    1 
ATOM   1027 N  N     . GLU A 1 201 ? 122.507 94.846  134.774 1.00 40.45 ? 201 GLU A N     1 
ATOM   1028 C  CA    . GLU A 1 201 ? 121.566 94.846  133.655 1.00 40.45 ? 201 GLU A CA    1 
ATOM   1029 C  C     . GLU A 1 201 ? 121.404 96.242  133.065 1.00 40.45 ? 201 GLU A C     1 
ATOM   1030 O  O     . GLU A 1 201 ? 121.455 96.417  131.841 1.00 40.45 ? 201 GLU A O     1 
ATOM   1031 C  CB    . GLU A 1 201 ? 120.211 94.296  134.098 1.00 40.45 ? 201 GLU A CB    1 
ATOM   1032 C  CG    . GLU A 1 201 ? 120.180 92.799  134.278 1.00 40.45 ? 201 GLU A CG    1 
ATOM   1033 C  CD    . GLU A 1 201 ? 120.311 92.072  132.960 1.00 40.45 ? 201 GLU A CD    1 
ATOM   1034 O  OE1   . GLU A 1 201 ? 119.836 92.613  131.940 1.00 40.45 ? 201 GLU A OE1   1 
ATOM   1035 O  OE2   . GLU A 1 201 ? 120.885 90.964  132.940 1.00 40.45 ? 201 GLU A OE2   1 
ATOM   1036 N  N     . VAL A 1 202 ? 121.219 97.248  133.920 1.00 35.82 ? 202 VAL A N     1 
ATOM   1037 C  CA    . VAL A 1 202 ? 121.065 98.615  133.432 1.00 35.82 ? 202 VAL A CA    1 
ATOM   1038 C  C     . VAL A 1 202 ? 122.335 99.073  132.727 1.00 35.82 ? 202 VAL A C     1 
ATOM   1039 O  O     . VAL A 1 202 ? 122.280 99.697  131.658 1.00 35.82 ? 202 VAL A O     1 
ATOM   1040 C  CB    . VAL A 1 202 ? 120.688 99.560  134.588 1.00 35.82 ? 202 VAL A CB    1 
ATOM   1041 C  CG1   . VAL A 1 202 ? 120.465 100.957 134.068 1.00 35.82 ? 202 VAL A CG1   1 
ATOM   1042 C  CG2   . VAL A 1 202 ? 119.444 99.082  135.281 1.00 35.82 ? 202 VAL A CG2   1 
ATOM   1043 N  N     . VAL A 1 203 ? 123.498 98.767  133.310 1.00 34.32 ? 203 VAL A N     1 
ATOM   1044 C  CA    . VAL A 1 203 ? 124.765 99.187  132.710 1.00 34.32 ? 203 VAL A CA    1 
ATOM   1045 C  C     . VAL A 1 203 ? 124.927 98.586  131.316 1.00 34.32 ? 203 VAL A C     1 
ATOM   1046 O  O     . VAL A 1 203 ? 125.220 99.294  130.339 1.00 34.32 ? 203 VAL A O     1 
ATOM   1047 C  CB    . VAL A 1 203 ? 125.938 98.803  133.629 1.00 34.32 ? 203 VAL A CB    1 
ATOM   1048 C  CG1   . VAL A 1 203 ? 127.234 98.828  132.866 1.00 34.32 ? 203 VAL A CG1   1 
ATOM   1049 C  CG2   . VAL A 1 203 ? 126.007 99.743  134.813 1.00 34.32 ? 203 VAL A CG2   1 
ATOM   1050 N  N     . ALA A 1 204 ? 124.732 97.271  131.204 1.00 34.74 ? 204 ALA A N     1 
ATOM   1051 C  CA    . ALA A 1 204 ? 124.911 96.595  129.926 1.00 34.74 ? 204 ALA A CA    1 
ATOM   1052 C  C     . ALA A 1 204 ? 123.918 97.096  128.891 1.00 34.74 ? 204 ALA A C     1 
ATOM   1053 O  O     . ALA A 1 204 ? 124.278 97.299  127.726 1.00 34.74 ? 204 ALA A O     1 
ATOM   1054 C  CB    . ALA A 1 204 ? 124.777 95.086  130.110 1.00 34.74 ? 204 ALA A CB    1 
ATOM   1055 N  N     . ARG A 1 205 ? 122.661 97.299  129.292 1.00 33.27 ? 205 ARG A N     1 
ATOM   1056 C  CA    . ARG A 1 205 ? 121.669 97.793  128.345 1.00 33.27 ? 205 ARG A CA    1 
ATOM   1057 C  C     . ARG A 1 205 ? 122.028 99.186  127.846 1.00 33.27 ? 205 ARG A C     1 
ATOM   1058 O  O     . ARG A 1 205 ? 121.879 99.484  126.655 1.00 33.27 ? 205 ARG A O     1 
ATOM   1059 C  CB    . ARG A 1 205 ? 120.282 97.788  128.986 1.00 33.27 ? 205 ARG A CB    1 
ATOM   1060 C  CG    . ARG A 1 205 ? 119.604 96.427  128.984 1.00 33.27 ? 205 ARG A CG    1 
ATOM   1061 C  CD    . ARG A 1 205 ? 118.652 96.286  130.158 1.00 33.27 ? 205 ARG A CD    1 
ATOM   1062 N  NE    . ARG A 1 205 ? 117.676 95.221  129.964 1.00 33.27 ? 205 ARG A NE    1 
ATOM   1063 C  CZ    . ARG A 1 205 ? 116.367 95.412  129.882 1.00 33.27 ? 205 ARG A CZ    1 
ATOM   1064 N  NH1   . ARG A 1 205 ? 115.840 96.623  129.951 1.00 33.27 ? 205 ARG A NH1   1 
ATOM   1065 N  NH2   . ARG A 1 205 ? 115.566 94.363  129.728 1.00 33.27 ? 205 ARG A NH2   1 
ATOM   1066 N  N     . GLN A 1 206 ? 122.513 100.054 128.738 1.00 32.35 ? 206 GLN A N     1 
ATOM   1067 C  CA    . GLN A 1 206 ? 122.854 101.406 128.308 1.00 32.35 ? 206 GLN A CA    1 
ATOM   1068 C  C     . GLN A 1 206 ? 124.051 101.410 127.366 1.00 32.35 ? 206 GLN A C     1 
ATOM   1069 O  O     . GLN A 1 206 ? 124.099 102.208 126.424 1.00 32.35 ? 206 GLN A O     1 
ATOM   1070 C  CB    . GLN A 1 206 ? 123.121 102.304 129.511 1.00 32.35 ? 206 GLN A CB    1 
ATOM   1071 C  CG    . GLN A 1 206 ? 123.126 103.773 129.142 1.00 32.35 ? 206 GLN A CG    1 
ATOM   1072 C  CD    . GLN A 1 206 ? 123.172 104.673 130.344 1.00 32.35 ? 206 GLN A CD    1 
ATOM   1073 O  OE1   . GLN A 1 206 ? 123.384 104.216 131.464 1.00 32.35 ? 206 GLN A OE1   1 
ATOM   1074 N  NE2   . GLN A 1 206 ? 122.980 105.967 130.122 1.00 32.35 ? 206 GLN A NE2   1 
ATOM   1075 N  N     . LEU A 1 207 ? 125.035 100.539 127.604 1.00 33.85 ? 207 LEU A N     1 
ATOM   1076 C  CA    . LEU A 1 207 ? 126.184 100.502 126.701 1.00 33.85 ? 207 LEU A CA    1 
ATOM   1077 C  C     . LEU A 1 207 ? 125.820 99.890  125.350 1.00 33.85 ? 207 LEU A C     1 
ATOM   1078 O  O     . LEU A 1 207 ? 126.314 100.337 124.303 1.00 33.85 ? 207 LEU A O     1 
ATOM   1079 C  CB    . LEU A 1 207 ? 127.340 99.741  127.342 1.00 33.85 ? 207 LEU A CB    1 
ATOM   1080 C  CG    . LEU A 1 207 ? 128.069 100.499 128.449 1.00 33.85 ? 207 LEU A CG    1 
ATOM   1081 C  CD1   . LEU A 1 207 ? 129.402 99.851  128.739 1.00 33.85 ? 207 LEU A CD1   1 
ATOM   1082 C  CD2   . LEU A 1 207 ? 128.243 101.960 128.085 1.00 33.85 ? 207 LEU A CD2   1 
ATOM   1083 N  N     . ARG A 1 208 ? 124.965 98.862  125.349 1.00 37.36 ? 208 ARG A N     1 
ATOM   1084 C  CA    . ARG A 1 208 ? 124.532 98.259  124.096 1.00 37.36 ? 208 ARG A CA    1 
ATOM   1085 C  C     . ARG A 1 208 ? 123.652 99.189  123.276 1.00 37.36 ? 208 ARG A C     1 
ATOM   1086 O  O     . ARG A 1 208 ? 123.697 99.133  122.045 1.00 37.36 ? 208 ARG A O     1 
ATOM   1087 C  CB    . ARG A 1 208 ? 123.789 96.952  124.364 1.00 37.36 ? 208 ARG A CB    1 
ATOM   1088 C  CG    . ARG A 1 208 ? 124.688 95.818  124.789 1.00 37.36 ? 208 ARG A CG    1 
ATOM   1089 C  CD    . ARG A 1 208 ? 123.985 94.482  124.673 1.00 37.36 ? 208 ARG A CD    1 
ATOM   1090 N  NE    . ARG A 1 208 ? 123.007 94.284  125.734 1.00 37.36 ? 208 ARG A NE    1 
ATOM   1091 C  CZ    . ARG A 1 208 ? 123.017 93.261  126.575 1.00 37.36 ? 208 ARG A CZ    1 
ATOM   1092 N  NH1   . ARG A 1 208 ? 123.953 92.329  126.518 1.00 37.36 ? 208 ARG A NH1   1 
ATOM   1093 N  NH2   . ARG A 1 208 ? 122.070 93.176  127.504 1.00 37.36 ? 208 ARG A NH2   1 
ATOM   1094 N  N     . SER A 1 209 ? 122.849 100.036 123.921 1.00 35.78 ? 209 SER A N     1 
ATOM   1095 C  CA    . SER A 1 209 ? 122.037 100.982 123.165 1.00 35.78 ? 209 SER A CA    1 
ATOM   1096 C  C     . SER A 1 209 ? 122.883 102.012 122.428 1.00 35.78 ? 209 SER A C     1 
ATOM   1097 O  O     . SER A 1 209 ? 122.388 102.637 121.485 1.00 35.78 ? 209 SER A O     1 
ATOM   1098 C  CB    . SER A 1 209 ? 121.048 101.687 124.096 1.00 35.78 ? 209 SER A CB    1 
ATOM   1099 O  OG    . SER A 1 209 ? 120.593 102.908 123.541 1.00 35.78 ? 209 SER A OG    1 
ATOM   1100 N  N     . HIS A 1 210 ? 124.141 102.197 122.830 1.00 37.84 ? 210 HIS A N     1 
ATOM   1101 C  CA    . HIS A 1 210 ? 125.033 103.172 122.213 1.00 37.84 ? 210 HIS A CA    1 
ATOM   1102 C  C     . HIS A 1 210 ? 126.015 102.557 121.229 1.00 37.84 ? 210 HIS A C     1 
ATOM   1103 O  O     . HIS A 1 210 ? 126.357 103.202 120.232 1.00 37.84 ? 210 HIS A O     1 
ATOM   1104 C  CB    . HIS A 1 210 ? 125.821 103.926 123.290 1.00 37.84 ? 210 HIS A CB    1 
ATOM   1105 C  CG    . HIS A 1 210 ? 126.854 104.863 122.745 1.00 37.84 ? 210 HIS A CG    1 
ATOM   1106 N  ND1   . HIS A 1 210 ? 126.533 106.094 122.217 1.00 37.84 ? 210 HIS A ND1   1 
ATOM   1107 C  CD2   . HIS A 1 210 ? 128.203 104.765 122.674 1.00 37.84 ? 210 HIS A CD2   1 
ATOM   1108 C  CE1   . HIS A 1 210 ? 127.637 106.707 121.828 1.00 37.84 ? 210 HIS A CE1   1 
ATOM   1109 N  NE2   . HIS A 1 210 ? 128.664 105.923 122.096 1.00 37.84 ? 210 HIS A NE2   1 
ATOM   1110 N  N     . ASN A 1 211 ? 126.481 101.333 121.485 1.00 39.17 ? 211 ASN A N     1 
ATOM   1111 C  CA    . ASN A 1 211 ? 127.448 100.717 120.579 1.00 39.17 ? 211 ASN A CA    1 
ATOM   1112 C  C     . ASN A 1 211 ? 126.866 100.523 119.180 1.00 39.17 ? 211 ASN A C     1 
ATOM   1113 O  O     . ASN A 1 211 ? 127.543 100.778 118.172 1.00 39.17 ? 211 ASN A O     1 
ATOM   1114 C  CB    . ASN A 1 211 ? 127.915 99.383  121.148 1.00 39.17 ? 211 ASN A CB    1 
ATOM   1115 C  CG    . ASN A 1 211 ? 128.805 98.631  120.194 1.00 39.17 ? 211 ASN A CG    1 
ATOM   1116 O  OD1   . ASN A 1 211 ? 128.479 97.530  119.755 1.00 39.17 ? 211 ASN A OD1   1 
ATOM   1117 N  ND2   . ASN A 1 211 ? 129.943 99.223  119.866 1.00 39.17 ? 211 ASN A ND2   1 
ATOM   1118 N  N     . GLU A 1 212 ? 125.616 100.062 119.099 1.00 40.50 ? 212 GLU A N     1 
ATOM   1119 C  CA    . GLU A 1 212 ? 124.989 99.837  117.801 1.00 40.50 ? 212 GLU A CA    1 
ATOM   1120 C  C     . GLU A 1 212 ? 124.876 101.140 117.022 1.00 40.50 ? 212 GLU A C     1 
ATOM   1121 O  O     . GLU A 1 212 ? 125.157 101.188 115.815 1.00 40.50 ? 212 GLU A O     1 
ATOM   1122 C  CB    . GLU A 1 212 ? 123.603 99.221  117.990 1.00 40.50 ? 212 GLU A CB    1 
ATOM   1123 C  CG    . GLU A 1 212 ? 123.547 98.050  118.957 1.00 40.50 ? 212 GLU A CG    1 
ATOM   1124 C  CD    . GLU A 1 212 ? 124.369 96.859  118.513 1.00 40.50 ? 212 GLU A CD    1 
ATOM   1125 O  OE1   . GLU A 1 212 ? 124.536 96.666  117.290 1.00 40.50 ? 212 GLU A OE1   1 
ATOM   1126 O  OE2   . GLU A 1 212 ? 124.846 96.111  119.392 1.00 40.50 ? 212 GLU A OE2   1 
ATOM   1127 N  N     . THR A 1 213 ? 124.465 102.210 117.706 1.00 37.41 ? 213 THR A N     1 
ATOM   1128 C  CA    . THR A 1 213 ? 124.367 103.516 117.072 1.00 37.41 ? 213 THR A CA    1 
ATOM   1129 C  C     . THR A 1 213 ? 125.731 104.002 116.600 1.00 37.41 ? 213 THR A C     1 
ATOM   1130 O  O     . THR A 1 213 ? 125.848 104.581 115.517 1.00 37.41 ? 213 THR A O     1 
ATOM   1131 C  CB    . THR A 1 213 ? 123.742 104.513 118.045 1.00 37.41 ? 213 THR A CB    1 
ATOM   1132 O  OG1   . THR A 1 213 ? 122.409 104.096 118.359 1.00 37.41 ? 213 THR A OG1   1 
ATOM   1133 C  CG2   . THR A 1 213 ? 123.701 105.902 117.441 1.00 37.41 ? 213 THR A CG2   1 
ATOM   1134 N  N     . TYR A 1 214 ? 126.774 103.773 117.399 1.00 35.72 ? 214 TYR A N     1 
ATOM   1135 C  CA    . TYR A 1 214 ? 128.116 104.185 116.997 1.00 35.72 ? 214 TYR A CA    1 
ATOM   1136 C  C     . TYR A 1 214 ? 128.543 103.495 115.708 1.00 35.72 ? 214 TYR A C     1 
ATOM   1137 O  O     . TYR A 1 214 ? 129.021 104.150 114.768 1.00 35.72 ? 214 TYR A O     1 
ATOM   1138 C  CB    . TYR A 1 214 ? 129.095 103.887 118.128 1.00 35.72 ? 214 TYR A CB    1 
ATOM   1139 C  CG    . TYR A 1 214 ? 130.563 104.032 117.798 1.00 35.72 ? 214 TYR A CG    1 
ATOM   1140 C  CD1   . TYR A 1 214 ? 131.225 105.229 118.016 1.00 35.72 ? 214 TYR A CD1   1 
ATOM   1141 C  CD2   . TYR A 1 214 ? 131.297 102.959 117.316 1.00 35.72 ? 214 TYR A CD2   1 
ATOM   1142 C  CE1   . TYR A 1 214 ? 132.569 105.360 117.740 1.00 35.72 ? 214 TYR A CE1   1 
ATOM   1143 C  CE2   . TYR A 1 214 ? 132.640 103.082 117.036 1.00 35.72 ? 214 TYR A CE2   1 
ATOM   1144 C  CZ    . TYR A 1 214 ? 133.271 104.284 117.250 1.00 35.72 ? 214 TYR A CZ    1 
ATOM   1145 O  OH    . TYR A 1 214 ? 134.610 104.418 116.975 1.00 35.72 ? 214 TYR A OH    1 
ATOM   1146 N  N     . HIS A 1 215 ? 128.368 102.172 115.637 1.00 39.25 ? 215 HIS A N     1 
ATOM   1147 C  CA    . HIS A 1 215 ? 128.737 101.472 114.408 1.00 39.25 ? 215 HIS A CA    1 
ATOM   1148 C  C     . HIS A 1 215 ? 127.915 101.938 113.213 1.00 39.25 ? 215 HIS A C     1 
ATOM   1149 O  O     . HIS A 1 215 ? 128.467 102.141 112.123 1.00 39.25 ? 215 HIS A O     1 
ATOM   1150 C  CB    . HIS A 1 215 ? 128.632 99.957  114.571 1.00 39.25 ? 215 HIS A CB    1 
ATOM   1151 C  CG    . HIS A 1 215 ? 129.604 99.384  115.548 1.00 39.25 ? 215 HIS A CG    1 
ATOM   1152 N  ND1   . HIS A 1 215 ? 130.942 99.237  115.251 1.00 39.25 ? 215 HIS A ND1   1 
ATOM   1153 C  CD2   . HIS A 1 215 ? 129.440 98.887  116.795 1.00 39.25 ? 215 HIS A CD2   1 
ATOM   1154 C  CE1   . HIS A 1 215 ? 131.565 98.695  116.280 1.00 39.25 ? 215 HIS A CE1   1 
ATOM   1155 N  NE2   . HIS A 1 215 ? 130.676 98.471  117.230 1.00 39.25 ? 215 HIS A NE2   1 
ATOM   1156 N  N     . GLU A 1 216 ? 126.600 102.106 113.376 1.00 40.80 ? 216 GLU A N     1 
ATOM   1157 C  CA    . GLU A 1 216 ? 125.828 102.523 112.209 1.00 40.80 ? 216 GLU A CA    1 
ATOM   1158 C  C     . GLU A 1 216 ? 126.185 103.944 111.793 1.00 40.80 ? 216 GLU A C     1 
ATOM   1159 O  O     . GLU A 1 216 ? 126.151 104.264 110.600 1.00 40.80 ? 216 GLU A O     1 
ATOM   1160 C  CB    . GLU A 1 216 ? 124.323 102.395 112.455 1.00 40.80 ? 216 GLU A CB    1 
ATOM   1161 C  CG    . GLU A 1 216 ? 123.715 103.418 113.390 1.00 40.80 ? 216 GLU A CG    1 
ATOM   1162 C  CD    . GLU A 1 216 ? 122.221 103.216 113.566 1.00 40.80 ? 216 GLU A CD    1 
ATOM   1163 O  OE1   . GLU A 1 216 ? 121.681 102.247 112.991 1.00 40.80 ? 216 GLU A OE1   1 
ATOM   1164 O  OE2   . GLU A 1 216 ? 121.585 104.029 114.270 1.00 40.80 ? 216 GLU A OE2   1 
ATOM   1165 N  N     . TYR A 1 217 ? 126.562 104.795 112.750 1.00 38.74 ? 217 TYR A N     1 
ATOM   1166 C  CA    . TYR A 1 217 ? 127.000 106.150 112.431 1.00 38.74 ? 217 TYR A CA    1 
ATOM   1167 C  C     . TYR A 1 217 ? 128.267 106.131 111.588 1.00 38.74 ? 217 TYR A C     1 
ATOM   1168 O  O     . TYR A 1 217 ? 128.364 106.828 110.567 1.00 38.74 ? 217 TYR A O     1 
ATOM   1169 C  CB    . TYR A 1 217 ? 127.222 106.925 113.731 1.00 38.74 ? 217 TYR A CB    1 
ATOM   1170 C  CG    . TYR A 1 217 ? 127.598 108.377 113.568 1.00 38.74 ? 217 TYR A CG    1 
ATOM   1171 C  CD1   . TYR A 1 217 ? 128.926 108.762 113.473 1.00 38.74 ? 217 TYR A CD1   1 
ATOM   1172 C  CD2   . TYR A 1 217 ? 126.628 109.365 113.534 1.00 38.74 ? 217 TYR A CD2   1 
ATOM   1173 C  CE1   . TYR A 1 217 ? 129.274 110.087 113.333 1.00 38.74 ? 217 TYR A CE1   1 
ATOM   1174 C  CE2   . TYR A 1 217 ? 126.967 110.694 113.395 1.00 38.74 ? 217 TYR A CE2   1 
ATOM   1175 C  CZ    . TYR A 1 217 ? 128.292 111.047 113.295 1.00 38.74 ? 217 TYR A CZ    1 
ATOM   1176 O  OH    . TYR A 1 217 ? 128.638 112.368 113.155 1.00 38.74 ? 217 TYR A OH    1 
ATOM   1177 N  N     . LEU A 1 218 ? 129.255 105.334 112.002 1.00 38.16 ? 218 LEU A N     1 
ATOM   1178 C  CA    . LEU A 1 218 ? 130.495 105.259 111.234 1.00 38.16 ? 218 LEU A CA    1 
ATOM   1179 C  C     . LEU A 1 218 ? 130.251 104.674 109.847 1.00 38.16 ? 218 LEU A C     1 
ATOM   1180 O  O     . LEU A 1 218 ? 130.809 105.157 108.850 1.00 38.16 ? 218 LEU A O     1 
ATOM   1181 C  CB    . LEU A 1 218 ? 131.537 104.442 111.992 1.00 38.16 ? 218 LEU A CB    1 
ATOM   1182 C  CG    . LEU A 1 218 ? 132.196 105.163 113.166 1.00 38.16 ? 218 LEU A CG    1 
ATOM   1183 C  CD1   . LEU A 1 218 ? 133.501 104.491 113.546 1.00 38.16 ? 218 LEU A CD1   1 
ATOM   1184 C  CD2   . LEU A 1 218 ? 132.419 106.624 112.844 1.00 38.16 ? 218 LEU A CD2   1 
ATOM   1185 N  N     . ASN A 1 219 ? 129.413 103.637 109.760 1.00 42.43 ? 219 ASN A N     1 
ATOM   1186 C  CA    . ASN A 1 219 ? 129.096 103.056 108.459 1.00 42.43 ? 219 ASN A CA    1 
ATOM   1187 C  C     . ASN A 1 219 ? 128.431 104.076 107.546 1.00 42.43 ? 219 ASN A C     1 
ATOM   1188 O  O     . ASN A 1 219 ? 128.773 104.179 106.360 1.00 42.43 ? 219 ASN A O     1 
ATOM   1189 C  CB    . ASN A 1 219 ? 128.191 101.838 108.635 1.00 42.43 ? 219 ASN A CB    1 
ATOM   1190 C  CG    . ASN A 1 219 ? 128.931 100.637 109.179 1.00 42.43 ? 219 ASN A CG    1 
ATOM   1191 O  OD1   . ASN A 1 219 ? 129.794 100.765 110.046 1.00 42.43 ? 219 ASN A OD1   1 
ATOM   1192 N  ND2   . ASN A 1 219 ? 128.588 99.456  108.680 1.00 42.43 ? 219 ASN A ND2   1 
ATOM   1193 N  N     . GLN A 1 220 ? 127.476 104.840 108.080 1.00 41.57 ? 220 GLN A N     1 
ATOM   1194 C  CA    . GLN A 1 220 ? 126.781 105.827 107.265 1.00 41.57 ? 220 GLN A CA    1 
ATOM   1195 C  C     . GLN A 1 220 ? 127.726 106.920 106.793 1.00 41.57 ? 220 GLN A C     1 
ATOM   1196 O  O     . GLN A 1 220 ? 127.649 107.347 105.637 1.00 41.57 ? 220 GLN A O     1 
ATOM   1197 C  CB    . GLN A 1 220 ? 125.612 106.428 108.038 1.00 41.57 ? 220 GLN A CB    1 
ATOM   1198 C  CG    . GLN A 1 220 ? 124.675 107.249 107.180 1.00 41.57 ? 220 GLN A CG    1 
ATOM   1199 C  CD    . GLN A 1 220 ? 124.018 108.370 107.954 1.00 41.57 ? 220 GLN A CD    1 
ATOM   1200 O  OE1   . GLN A 1 220 ? 124.664 109.047 108.752 1.00 41.57 ? 220 GLN A OE1   1 
ATOM   1201 N  NE2   . GLN A 1 220 ? 122.727 108.573 107.722 1.00 41.57 ? 220 GLN A NE2   1 
ATOM   1202 N  N     . THR A 1 221 ? 128.629 107.388 107.661 1.00 43.02 ? 221 THR A N     1 
ATOM   1203 C  CA    . THR A 1 221 ? 129.539 108.443 107.220 1.00 43.02 ? 221 THR A CA    1 
ATOM   1204 C  C     . THR A 1 221 ? 130.505 107.927 106.158 1.00 43.02 ? 221 THR A C     1 
ATOM   1205 O  O     . THR A 1 221 ? 130.799 108.636 105.187 1.00 43.02 ? 221 THR A O     1 
ATOM   1206 C  CB    . THR A 1 221 ? 130.286 109.064 108.409 1.00 43.02 ? 221 THR A CB    1 
ATOM   1207 O  OG1   . THR A 1 221 ? 130.834 110.327 108.016 1.00 43.02 ? 221 THR A OG1   1 
ATOM   1208 C  CG2   . THR A 1 221 ? 131.419 108.185 108.895 1.00 43.02 ? 221 THR A CG2   1 
ATOM   1209 N  N     . HIS A 1 222 ? 130.972 106.680 106.287 1.00 46.55 ? 222 HIS A N     1 
ATOM   1210 C  CA    . HIS A 1 222 ? 131.863 106.136 105.265 1.00 46.55 ? 222 HIS A CA    1 
ATOM   1211 C  C     . HIS A 1 222 ? 131.148 105.980 103.929 1.00 46.55 ? 222 HIS A C     1 
ATOM   1212 O  O     . HIS A 1 222 ? 131.693 106.347 102.881 1.00 46.55 ? 222 HIS A O     1 
ATOM   1213 C  CB    . HIS A 1 222 ? 132.436 104.793 105.708 1.00 46.55 ? 222 HIS A CB    1 
ATOM   1214 C  CG    . HIS A 1 222 ? 132.954 103.963 104.575 1.00 46.55 ? 222 HIS A CG    1 
ATOM   1215 N  ND1   . HIS A 1 222 ? 132.228 102.936 104.012 1.00 46.55 ? 222 HIS A ND1   1 
ATOM   1216 C  CD2   . HIS A 1 222 ? 134.121 104.020 103.890 1.00 46.55 ? 222 HIS A CD2   1 
ATOM   1217 C  CE1   . HIS A 1 222 ? 132.929 102.390 103.034 1.00 46.55 ? 222 HIS A CE1   1 
ATOM   1218 N  NE2   . HIS A 1 222 ? 134.081 103.029 102.939 1.00 46.55 ? 222 HIS A NE2   1 
ATOM   1219 N  N     . GLU A 1 223 ? 129.932 105.429 103.943 1.00 46.92 ? 223 GLU A N     1 
ATOM   1220 C  CA    . GLU A 1 223 ? 129.191 105.259 102.697 1.00 46.92 ? 223 GLU A CA    1 
ATOM   1221 C  C     . GLU A 1 223 ? 128.880 106.604 102.058 1.00 46.92 ? 223 GLU A C     1 
ATOM   1222 O  O     . GLU A 1 223 ? 128.985 106.765 100.835 1.00 46.92 ? 223 GLU A O     1 
ATOM   1223 C  CB    . GLU A 1 223 ? 127.901 104.483 102.954 1.00 46.92 ? 223 GLU A CB    1 
ATOM   1224 C  CG    . GLU A 1 223 ? 128.005 102.996 102.682 1.00 46.92 ? 223 GLU A CG    1 
ATOM   1225 C  CD    . GLU A 1 223 ? 126.704 102.267 102.950 1.00 46.92 ? 223 GLU A CD    1 
ATOM   1226 O  OE1   . GLU A 1 223 ? 125.638 102.914 102.893 1.00 46.92 ? 223 GLU A OE1   1 
ATOM   1227 O  OE2   . GLU A 1 223 ? 126.749 101.049 103.223 1.00 46.92 ? 223 GLU A OE2   1 
ATOM   1228 N  N     . MET A 1 224 ? 128.504 107.586 102.876 1.00 46.46 ? 224 MET A N     1 
ATOM   1229 C  CA    . MET A 1 224 ? 128.135 108.896 102.365 1.00 46.46 ? 224 MET A CA    1 
ATOM   1230 C  C     . MET A 1 224 ? 129.342 109.654 101.825 1.00 46.46 ? 224 MET A C     1 
ATOM   1231 O  O     . MET A 1 224 ? 129.193 110.490 100.927 1.00 46.46 ? 224 MET A O     1 
ATOM   1232 C  CB    . MET A 1 224 ? 127.422 109.661 103.479 1.00 46.46 ? 224 MET A CB    1 
ATOM   1233 C  CG    . MET A 1 224 ? 126.916 111.022 103.129 1.00 46.46 ? 224 MET A CG    1 
ATOM   1234 S  SD    . MET A 1 224 ? 126.077 111.751 104.548 1.00 46.46 ? 224 MET A SD    1 
ATOM   1235 C  CE    . MET A 1 224 ? 127.459 112.100 105.619 1.00 46.46 ? 224 MET A CE    1 
ATOM   1236 N  N     . LYS A 1 225 ? 130.539 109.383 102.350 1.00 47.40 ? 225 LYS A N     1 
ATOM   1237 C  CA    . LYS A 1 225 ? 131.748 109.947 101.755 1.00 47.40 ? 225 LYS A CA    1 
ATOM   1238 C  C     . LYS A 1 225 ? 132.097 109.252 100.443 1.00 47.40 ? 225 LYS A C     1 
ATOM   1239 O  O     . LYS A 1 225 ? 132.435 109.909 99.448  1.00 47.40 ? 225 LYS A O     1 
ATOM   1240 C  CB    . LYS A 1 225 ? 132.910 109.845 102.743 1.00 47.40 ? 225 LYS A CB    1 
ATOM   1241 C  CG    . LYS A 1 225 ? 134.239 110.327 102.201 1.00 47.40 ? 225 LYS A CG    1 
ATOM   1242 C  CD    . LYS A 1 225 ? 135.291 110.361 103.294 1.00 47.40 ? 225 LYS A CD    1 
ATOM   1243 C  CE    . LYS A 1 225 ? 136.513 111.153 102.862 1.00 47.40 ? 225 LYS A CE    1 
ATOM   1244 N  NZ    . LYS A 1 225 ? 137.165 110.556 101.665 1.00 47.40 ? 225 LYS A NZ    1 
ATOM   1245 N  N     . THR A 1 226 ? 132.027 107.917 100.421 1.00 50.21 ? 226 THR A N     1 
ATOM   1246 C  CA    . THR A 1 226 ? 132.386 107.188 99.208  1.00 50.21 ? 226 THR A CA    1 
ATOM   1247 C  C     . THR A 1 226 ? 131.421 107.483 98.071  1.00 50.21 ? 226 THR A C     1 
ATOM   1248 O  O     . THR A 1 226 ? 131.788 107.343 96.900  1.00 50.21 ? 226 THR A O     1 
ATOM   1249 C  CB    . THR A 1 226 ? 132.435 105.682 99.470  1.00 50.21 ? 226 THR A CB    1 
ATOM   1250 O  OG1   . THR A 1 226 ? 131.164 105.232 99.953  1.00 50.21 ? 226 THR A OG1   1 
ATOM   1251 C  CG2   . THR A 1 226 ? 133.511 105.350 100.489 1.00 50.21 ? 226 THR A CG2   1 
ATOM   1252 N  N     . LYS A 1 227 ? 130.186 107.875 98.387  1.00 48.13 ? 227 LYS A N     1 
ATOM   1253 C  CA    . LYS A 1 227 ? 129.265 108.278 97.331  1.00 48.13 ? 227 LYS A CA    1 
ATOM   1254 C  C     . LYS A 1 227 ? 129.780 109.509 96.593  1.00 48.13 ? 227 LYS A C     1 
ATOM   1255 O  O     . LYS A 1 227 ? 129.707 109.578 95.361  1.00 48.13 ? 227 LYS A O     1 
ATOM   1256 C  CB    . LYS A 1 227 ? 127.876 108.539 97.909  1.00 48.13 ? 227 LYS A CB    1 
ATOM   1257 C  CG    . LYS A 1 227 ? 126.940 109.260 96.958  1.00 48.13 ? 227 LYS A CG    1 
ATOM   1258 C  CD    . LYS A 1 227 ? 125.540 108.679 97.018  1.00 48.13 ? 227 LYS A CD    1 
ATOM   1259 C  CE    . LYS A 1 227 ? 124.605 109.396 96.057  1.00 48.13 ? 227 LYS A CE    1 
ATOM   1260 N  NZ    . LYS A 1 227 ? 124.378 110.815 96.452  1.00 48.13 ? 227 LYS A NZ    1 
ATOM   1261 N  N     . VAL A 1 228 ? 130.299 110.492 97.327  1.00 50.64 ? 228 VAL A N     1 
ATOM   1262 C  CA    . VAL A 1 228 ? 130.884 111.666 96.686  1.00 50.64 ? 228 VAL A CA    1 
ATOM   1263 C  C     . VAL A 1 228 ? 132.192 111.316 95.989  1.00 50.64 ? 228 VAL A C     1 
ATOM   1264 O  O     . VAL A 1 228 ? 132.484 111.842 94.909  1.00 50.64 ? 228 VAL A O     1 
ATOM   1265 C  CB    . VAL A 1 228 ? 131.085 112.795 97.712  1.00 50.64 ? 228 VAL A CB    1 
ATOM   1266 C  CG1   . VAL A 1 228 ? 131.784 113.981 97.072  1.00 50.64 ? 228 VAL A CG1   1 
ATOM   1267 C  CG2   . VAL A 1 228 ? 129.754 113.219 98.295  1.00 50.64 ? 228 VAL A CG2   1 
ATOM   1268 N  N     . ALA A 1 229 ? 132.997 110.432 96.585  1.00 54.85 ? 229 ALA A N     1 
ATOM   1269 C  CA    . ALA A 1 229 ? 134.301 110.113 96.006  1.00 54.85 ? 229 ALA A CA    1 
ATOM   1270 C  C     . ALA A 1 229 ? 134.169 109.474 94.627  1.00 54.85 ? 229 ALA A C     1 
ATOM   1271 O  O     . ALA A 1 229 ? 135.098 109.545 93.815  1.00 54.85 ? 229 ALA A O     1 
ATOM   1272 C  CB    . ALA A 1 229 ? 135.083 109.197 96.947  1.00 54.85 ? 229 ALA A CB    1 
ATOM   1273 N  N     . ASN A 1 230 ? 133.034 108.833 94.346  1.00 55.51 ? 230 ASN A N     1 
ATOM   1274 C  CA    . ASN A 1 230 ? 132.841 108.168 93.063  1.00 55.51 ? 230 ASN A CA    1 
ATOM   1275 C  C     . ASN A 1 230 ? 132.200 109.058 92.007  1.00 55.51 ? 230 ASN A C     1 
ATOM   1276 O  O     . ASN A 1 230 ? 132.139 108.653 90.842  1.00 55.51 ? 230 ASN A O     1 
ATOM   1277 C  CB    . ASN A 1 230 ? 131.987 106.910 93.241  1.00 55.51 ? 230 ASN A CB    1 
ATOM   1278 C  CG    . ASN A 1 230 ? 132.559 105.958 94.267  1.00 55.51 ? 230 ASN A CG    1 
ATOM   1279 O  OD1   . ASN A 1 230 ? 133.649 106.176 94.794  1.00 55.51 ? 230 ASN A OD1   1 
ATOM   1280 N  ND2   . ASN A 1 230 ? 131.823 104.893 94.560  1.00 55.51 ? 230 ASN A ND2   1 
ATOM   1281 N  N     . ASN A 1 231 ? 131.725 110.246 92.369  1.00 55.58 ? 231 ASN A N     1 
ATOM   1282 C  CA    . ASN A 1 231 ? 130.994 111.111 91.451  1.00 55.58 ? 231 ASN A CA    1 
ATOM   1283 C  C     . ASN A 1 231 ? 131.774 112.403 91.237  1.00 55.58 ? 231 ASN A C     1 
ATOM   1284 O  O     . ASN A 1 231 ? 131.570 113.382 91.963  1.00 55.58 ? 231 ASN A O     1 
ATOM   1285 C  CB    . ASN A 1 231 ? 129.596 111.410 91.991  1.00 55.58 ? 231 ASN A CB    1 
ATOM   1286 C  CG    . ASN A 1 231 ? 128.720 112.133 90.986  1.00 55.58 ? 231 ASN A CG    1 
ATOM   1287 O  OD1   . ASN A 1 231 ? 129.152 112.448 89.878  1.00 55.58 ? 231 ASN A OD1   1 
ATOM   1288 N  ND2   . ASN A 1 231 ? 127.479 112.405 91.373  1.00 55.58 ? 231 ASN A ND2   1 
ATOM   1289 N  N     . LEU A 1 232 ? 132.646 112.410 90.230  1.00 58.09 ? 232 LEU A N     1 
ATOM   1290 C  CA    . LEU A 1 232 ? 133.421 113.593 89.879  1.00 58.09 ? 232 LEU A CA    1 
ATOM   1291 C  C     . LEU A 1 232 ? 133.269 113.873 88.393  1.00 58.09 ? 232 LEU A C     1 
ATOM   1292 O  O     . LEU A 1 232 ? 133.284 112.947 87.578  1.00 58.09 ? 232 LEU A O     1 
ATOM   1293 C  CB    . LEU A 1 232 ? 134.907 113.432 90.228  1.00 58.09 ? 232 LEU A CB    1 
ATOM   1294 C  CG    . LEU A 1 232 ? 135.360 113.586 91.683  1.00 58.09 ? 232 LEU A CG    1 
ATOM   1295 C  CD1   . LEU A 1 232 ? 134.922 112.414 92.541  1.00 58.09 ? 232 LEU A CD1   1 
ATOM   1296 C  CD2   . LEU A 1 232 ? 136.867 113.773 91.761  1.00 58.09 ? 232 LEU A CD2   1 
ATOM   1297 N  N     . THR A 1 233 ? 133.124 115.151 88.054  1.00 63.88 ? 233 THR A N     1 
ATOM   1298 C  CA    . THR A 1 233 ? 132.996 115.596 86.674  1.00 63.88 ? 233 THR A CA    1 
ATOM   1299 C  C     . THR A 1 233 ? 133.242 117.097 86.644  1.00 63.88 ? 233 THR A C     1 
ATOM   1300 O  O     . THR A 1 233 ? 133.319 117.747 87.689  1.00 63.88 ? 233 THR A O     1 
ATOM   1301 C  CB    . THR A 1 233 ? 131.618 115.256 86.095  1.00 63.88 ? 233 THR A CB    1 
ATOM   1302 O  OG1   . THR A 1 233 ? 131.579 115.608 84.707  1.00 63.88 ? 233 THR A OG1   1 
ATOM   1303 C  CG2   . THR A 1 233 ? 130.523 116.004 86.838  1.00 63.88 ? 233 THR A CG2   1 
ATOM   1304 N  N     . ASN A 1 234 ? 133.376 117.642 85.432  1.00 66.03 ? 234 ASN A N     1 
ATOM   1305 C  CA    . ASN A 1 234 ? 133.568 119.085 85.312  1.00 66.03 ? 234 ASN A CA    1 
ATOM   1306 C  C     . ASN A 1 234 ? 132.344 119.853 85.794  1.00 66.03 ? 234 ASN A C     1 
ATOM   1307 O  O     . ASN A 1 234 ? 132.478 120.964 86.321  1.00 66.03 ? 234 ASN A O     1 
ATOM   1308 C  CB    . ASN A 1 234 ? 133.909 119.471 83.870  1.00 66.03 ? 234 ASN A CB    1 
ATOM   1309 C  CG    . ASN A 1 234 ? 132.792 119.150 82.890  1.00 66.03 ? 234 ASN A CG    1 
ATOM   1310 O  OD1   . ASN A 1 234 ? 131.735 118.646 83.267  1.00 66.03 ? 234 ASN A OD1   1 
ATOM   1311 N  ND2   . ASN A 1 234 ? 133.024 119.454 81.620  1.00 66.03 ? 234 ASN A ND2   1 
ATOM   1312 N  N     . GLU A 1 235 ? 131.150 119.279 85.625  1.00 66.15 ? 235 GLU A N     1 
ATOM   1313 C  CA    . GLU A 1 235 ? 129.943 119.925 86.125  1.00 66.15 ? 235 GLU A CA    1 
ATOM   1314 C  C     . GLU A 1 235 ? 129.985 120.086 87.637  1.00 66.15 ? 235 GLU A C     1 
ATOM   1315 O  O     . GLU A 1 235 ? 129.567 121.124 88.158  1.00 66.15 ? 235 GLU A O     1 
ATOM   1316 C  CB    . GLU A 1 235 ? 128.704 119.128 85.720  1.00 66.15 ? 235 GLU A CB    1 
ATOM   1317 C  CG    . GLU A 1 235 ? 128.299 119.298 84.271  1.00 66.15 ? 235 GLU A CG    1 
ATOM   1318 C  CD    . GLU A 1 235 ? 128.517 118.037 83.461  1.00 66.15 ? 235 GLU A CD    1 
ATOM   1319 O  OE1   . GLU A 1 235 ? 129.410 117.243 83.821  1.00 66.15 ? 235 GLU A OE1   1 
ATOM   1320 O  OE2   . GLU A 1 235 ? 127.793 117.835 82.464  1.00 66.15 ? 235 GLU A OE2   1 
ATOM   1321 N  N     . PHE A 1 236 ? 130.482 119.079 88.356  1.00 59.80 ? 236 PHE A N     1 
ATOM   1322 C  CA    . PHE A 1 236 ? 130.546 119.171 89.811  1.00 59.80 ? 236 PHE A CA    1 
ATOM   1323 C  C     . PHE A 1 236 ? 131.440 120.325 90.249  1.00 59.80 ? 236 PHE A C     1 
ATOM   1324 O  O     . PHE A 1 236 ? 131.056 121.133 91.103  1.00 59.80 ? 236 PHE A O     1 
ATOM   1325 C  CB    . PHE A 1 236 ? 131.042 117.849 90.394  1.00 59.80 ? 236 PHE A CB    1 
ATOM   1326 C  CG    . PHE A 1 236 ? 131.323 117.904 91.865  1.00 59.80 ? 236 PHE A CG    1 
ATOM   1327 C  CD1   . PHE A 1 236 ? 130.354 118.339 92.752  1.00 59.80 ? 236 PHE A CD1   1 
ATOM   1328 C  CD2   . PHE A 1 236 ? 132.552 117.513 92.363  1.00 59.80 ? 236 PHE A CD2   1 
ATOM   1329 C  CE1   . PHE A 1 236 ? 130.608 118.390 94.106  1.00 59.80 ? 236 PHE A CE1   1 
ATOM   1330 C  CE2   . PHE A 1 236 ? 132.811 117.561 93.717  1.00 59.80 ? 236 PHE A CE2   1 
ATOM   1331 C  CZ    . PHE A 1 236 ? 131.838 118.001 94.589  1.00 59.80 ? 236 PHE A CZ    1 
ATOM   1332 N  N     . ASP A 1 237 ? 132.632 120.429 89.660  1.00 62.09 ? 237 ASP A N     1 
ATOM   1333 C  CA    . ASP A 1 237 ? 133.545 121.504 90.035  1.00 62.09 ? 237 ASP A CA    1 
ATOM   1334 C  C     . ASP A 1 237 ? 133.000 122.866 89.629  1.00 62.09 ? 237 ASP A C     1 
ATOM   1335 O  O     . ASP A 1 237 ? 133.147 123.848 90.369  1.00 62.09 ? 237 ASP A O     1 
ATOM   1336 C  CB    . ASP A 1 237 ? 134.918 121.264 89.414  1.00 62.09 ? 237 ASP A CB    1 
ATOM   1337 C  CG    . ASP A 1 237 ? 135.491 119.914 89.781  1.00 62.09 ? 237 ASP A CG    1 
ATOM   1338 O  OD1   . ASP A 1 237 ? 134.869 119.212 90.605  1.00 62.09 ? 237 ASP A OD1   1 
ATOM   1339 O  OD2   . ASP A 1 237 ? 136.563 119.556 89.251  1.00 62.09 ? 237 ASP A OD2   1 
ATOM   1340 N  N     . LEU A 1 238 ? 132.372 122.951 88.454  1.00 59.60 ? 238 LEU A N     1 
ATOM   1341 C  CA    . LEU A 1 238 ? 131.819 124.228 88.018  1.00 59.60 ? 238 LEU A CA    1 
ATOM   1342 C  C     . LEU A 1 238 ? 130.678 124.671 88.923  1.00 59.60 ? 238 LEU A C     1 
ATOM   1343 O  O     . LEU A 1 238 ? 130.551 125.860 89.233  1.00 59.60 ? 238 LEU A O     1 
ATOM   1344 C  CB    . LEU A 1 238 ? 131.359 124.136 86.565  1.00 59.60 ? 238 LEU A CB    1 
ATOM   1345 C  CG    . LEU A 1 238 ? 132.449 124.215 85.494  1.00 59.60 ? 238 LEU A CG    1 
ATOM   1346 C  CD1   . LEU A 1 238 ? 131.822 124.376 84.123  1.00 59.60 ? 238 LEU A CD1   1 
ATOM   1347 C  CD2   . LEU A 1 238 ? 133.433 125.340 85.773  1.00 59.60 ? 238 LEU A CD2   1 
ATOM   1348 N  N     . VAL A 1 239 ? 129.838 123.730 89.364  1.00 55.84 ? 239 VAL A N     1 
ATOM   1349 C  CA    . VAL A 1 239 ? 128.773 124.071 90.303  1.00 55.84 ? 239 VAL A CA    1 
ATOM   1350 C  C     . VAL A 1 239 ? 129.347 124.453 91.661  1.00 55.84 ? 239 VAL A C     1 
ATOM   1351 O  O     . VAL A 1 239 ? 128.800 125.322 92.346  1.00 55.84 ? 239 VAL A O     1 
ATOM   1352 C  CB    . VAL A 1 239 ? 127.757 122.920 90.414  1.00 55.84 ? 239 VAL A CB    1 
ATOM   1353 C  CG1   . VAL A 1 239 ? 126.722 123.223 91.483  1.00 55.84 ? 239 VAL A CG1   1 
ATOM   1354 C  CG2   . VAL A 1 239 ? 127.064 122.711 89.084  1.00 55.84 ? 239 VAL A CG2   1 
ATOM   1355 N  N     . CYS A 1 240 ? 130.447 123.823 92.080  1.00 56.90 ? 240 CYS A N     1 
ATOM   1356 C  CA    . CYS A 1 240 ? 131.108 124.255 93.310  1.00 56.90 ? 240 CYS A CA    1 
ATOM   1357 C  C     . CYS A 1 240 ? 131.587 125.699 93.195  1.00 56.90 ? 240 CYS A C     1 
ATOM   1358 O  O     . CYS A 1 240 ? 131.410 126.503 94.119  1.00 56.90 ? 240 CYS A O     1 
ATOM   1359 C  CB    . CYS A 1 240 ? 132.275 123.323 93.637  1.00 56.90 ? 240 CYS A CB    1 
ATOM   1360 S  SG    . CYS A 1 240 ? 131.783 121.706 94.268  1.00 56.90 ? 240 CYS A SG    1 
ATOM   1361 N  N     . GLU A 1 241 ? 132.192 126.048 92.057  1.00 58.27 ? 241 GLU A N     1 
ATOM   1362 C  CA    . GLU A 1 241 ? 132.624 127.427 91.834  1.00 58.27 ? 241 GLU A CA    1 
ATOM   1363 C  C     . GLU A 1 241 ? 131.437 128.386 91.819  1.00 58.27 ? 241 GLU A C     1 
ATOM   1364 O  O     . GLU A 1 241 ? 131.507 129.489 92.378  1.00 58.27 ? 241 GLU A O     1 
ATOM   1365 C  CB    . GLU A 1 241 ? 133.408 127.517 90.524  1.00 58.27 ? 241 GLU A CB    1 
ATOM   1366 C  CG    . GLU A 1 241 ? 133.814 128.925 90.125  1.00 58.27 ? 241 GLU A CG    1 
ATOM   1367 C  CD    . GLU A 1 241 ? 135.043 128.942 89.237  1.00 58.27 ? 241 GLU A CD    1 
ATOM   1368 O  OE1   . GLU A 1 241 ? 136.043 128.285 89.594  1.00 58.27 ? 241 GLU A OE1   1 
ATOM   1369 O  OE2   . GLU A 1 241 ? 135.009 129.609 88.182  1.00 58.27 ? 241 GLU A OE2   1 
ATOM   1370 N  N     . PHE A 1 242 ? 130.339 127.976 91.181  1.00 55.19 ? 242 PHE A N     1 
ATOM   1371 C  CA    . PHE A 1 242 ? 129.120 128.779 91.171  1.00 55.19 ? 242 PHE A CA    1 
ATOM   1372 C  C     . PHE A 1 242 ? 128.603 129.000 92.585  1.00 55.19 ? 242 PHE A C     1 
ATOM   1373 O  O     . PHE A 1 242 ? 128.164 130.103 92.931  1.00 55.19 ? 242 PHE A O     1 
ATOM   1374 C  CB    . PHE A 1 242 ? 128.066 128.080 90.311  1.00 55.19 ? 242 PHE A CB    1 
ATOM   1375 C  CG    . PHE A 1 242 ? 126.768 128.818 90.205  1.00 55.19 ? 242 PHE A CG    1 
ATOM   1376 C  CD1   . PHE A 1 242 ? 126.740 130.164 89.903  1.00 55.19 ? 242 PHE A CD1   1 
ATOM   1377 C  CD2   . PHE A 1 242 ? 125.570 128.155 90.395  1.00 55.19 ? 242 PHE A CD2   1 
ATOM   1378 C  CE1   . PHE A 1 242 ? 125.537 130.839 89.797  1.00 55.19 ? 242 PHE A CE1   1 
ATOM   1379 C  CE2   . PHE A 1 242 ? 124.366 128.821 90.292  1.00 55.19 ? 242 PHE A CE2   1 
ATOM   1380 C  CZ    . PHE A 1 242 ? 124.348 130.165 89.993  1.00 55.19 ? 242 PHE A CZ    1 
ATOM   1381 N  N     . ALA A 1 243 ? 128.652 127.957 93.416  1.00 53.61 ? 243 ALA A N     1 
ATOM   1382 C  CA    . ALA A 1 243 ? 128.209 128.071 94.800  1.00 53.61 ? 243 ALA A CA    1 
ATOM   1383 C  C     . ALA A 1 243 ? 129.092 129.027 95.585  1.00 53.61 ? 243 ALA A C     1 
ATOM   1384 O  O     . ALA A 1 243 ? 128.595 129.816 96.395  1.00 53.61 ? 243 ALA A O     1 
ATOM   1385 C  CB    . ALA A 1 243 ? 128.199 126.694 95.460  1.00 53.61 ? 243 ALA A CB    1 
ATOM   1386 N  N     . GLU A 1 244 ? 130.407 128.961 95.371  1.00 54.50 ? 244 GLU A N     1 
ATOM   1387 C  CA    . GLU A 1 244 ? 131.303 129.887 96.057  1.00 54.50 ? 244 GLU A CA    1 
ATOM   1388 C  C     . GLU A 1 244 ? 131.026 131.326 95.644  1.00 54.50 ? 244 GLU A C     1 
ATOM   1389 O  O     . GLU A 1 244 ? 131.015 132.232 96.487  1.00 54.50 ? 244 GLU A O     1 
ATOM   1390 C  CB    . GLU A 1 244 ? 132.760 129.521 95.782  1.00 54.50 ? 244 GLU A CB    1 
ATOM   1391 C  CG    . GLU A 1 244 ? 133.135 128.100 96.170  1.00 54.50 ? 244 GLU A CG    1 
ATOM   1392 C  CD    . GLU A 1 244 ? 132.578 127.691 97.517  1.00 54.50 ? 244 GLU A CD    1 
ATOM   1393 O  OE1   . GLU A 1 244 ? 133.030 128.242 98.542  1.00 54.50 ? 244 GLU A OE1   1 
ATOM   1394 O  OE2   . GLU A 1 244 ? 131.689 126.814 97.551  1.00 54.50 ? 244 GLU A OE2   1 
ATOM   1395 N  N     . VAL A 1 245 ? 130.790 131.556 94.351  1.00 54.17 ? 245 VAL A N     1 
ATOM   1396 C  CA    . VAL A 1 245 ? 130.468 132.904 93.884  1.00 54.17 ? 245 VAL A CA    1 
ATOM   1397 C  C     . VAL A 1 245 ? 129.160 133.387 94.501  1.00 54.17 ? 245 VAL A C     1 
ATOM   1398 O  O     . VAL A 1 245 ? 129.045 134.543 94.929  1.00 54.17 ? 245 VAL A O     1 
ATOM   1399 C  CB    . VAL A 1 245 ? 130.418 132.939 92.346  1.00 54.17 ? 245 VAL A CB    1 
ATOM   1400 C  CG1   . VAL A 1 245 ? 129.858 134.265 91.862  1.00 54.17 ? 245 VAL A CG1   1 
ATOM   1401 C  CG2   . VAL A 1 245 ? 131.803 132.706 91.772  1.00 54.17 ? 245 VAL A CG2   1 
ATOM   1402 N  N     . LEU A 1 246 ? 128.155 132.512 94.558  1.00 50.29 ? 246 LEU A N     1 
ATOM   1403 C  CA    . LEU A 1 246 ? 126.881 132.887 95.162  1.00 50.29 ? 246 LEU A CA    1 
ATOM   1404 C  C     . LEU A 1 246 ? 127.043 133.211 96.642  1.00 50.29 ? 246 LEU A C     1 
ATOM   1405 O  O     . LEU A 1 246 ? 126.434 134.161 97.147  1.00 50.29 ? 246 LEU A O     1 
ATOM   1406 C  CB    . LEU A 1 246 ? 125.858 131.771 94.964  1.00 50.29 ? 246 LEU A CB    1 
ATOM   1407 C  CG    . LEU A 1 246 ? 125.078 131.801 93.651  1.00 50.29 ? 246 LEU A CG    1 
ATOM   1408 C  CD1   . LEU A 1 246 ? 124.079 130.668 93.620  1.00 50.29 ? 246 LEU A CD1   1 
ATOM   1409 C  CD2   . LEU A 1 246 ? 124.379 133.133 93.468  1.00 50.29 ? 246 LEU A CD2   1 
ATOM   1410 N  N     . GLU A 1 247 ? 127.854 132.427 97.356  1.00 51.10 ? 247 GLU A N     1 
ATOM   1411 C  CA    . GLU A 1 247 ? 128.112 132.722 98.762  1.00 51.10 ? 247 GLU A CA    1 
ATOM   1412 C  C     . GLU A 1 247 ? 128.805 134.068 98.920  1.00 51.10 ? 247 GLU A C     1 
ATOM   1413 O  O     . GLU A 1 247 ? 128.501 134.826 99.848  1.00 51.10 ? 247 GLU A O     1 
ATOM   1414 C  CB    . GLU A 1 247 ? 128.950 131.612 99.394  1.00 51.10 ? 247 GLU A CB    1 
ATOM   1415 C  CG    . GLU A 1 247 ? 128.152 130.390 99.801  1.00 51.10 ? 247 GLU A CG    1 
ATOM   1416 C  CD    . GLU A 1 247 ? 129.004 129.345 100.484 1.00 51.10 ? 247 GLU A CD    1 
ATOM   1417 O  OE1   . GLU A 1 247 ? 130.022 129.721 101.101 1.00 51.10 ? 247 GLU A OE1   1 
ATOM   1418 O  OE2   . GLU A 1 247 ? 128.655 128.149 100.407 1.00 51.10 ? 247 GLU A OE2   1 
ATOM   1419 N  N     . GLU A 1 248 ? 129.743 134.380 98.024  1.00 54.71 ? 248 GLU A N     1 
ATOM   1420 C  CA    . GLU A 1 248 ? 130.373 135.696 98.050  1.00 54.71 ? 248 GLU A CA    1 
ATOM   1421 C  C     . GLU A 1 248 ? 129.347 136.800 97.814  1.00 54.71 ? 248 GLU A C     1 
ATOM   1422 O  O     . GLU A 1 248 ? 129.445 137.884 98.401  1.00 54.71 ? 248 GLU A O     1 
ATOM   1423 C  CB    . GLU A 1 248 ? 131.489 135.768 97.010  1.00 54.71 ? 248 GLU A CB    1 
ATOM   1424 C  CG    . GLU A 1 248 ? 132.409 136.968 97.172  1.00 54.71 ? 248 GLU A CG    1 
ATOM   1425 C  CD    . GLU A 1 248 ? 131.877 138.211 96.487  1.00 54.71 ? 248 GLU A CD    1 
ATOM   1426 O  OE1   . GLU A 1 248 ? 131.133 138.072 95.495  1.00 54.71 ? 248 GLU A OE1   1 
ATOM   1427 O  OE2   . GLU A 1 248 ? 132.199 139.327 96.946  1.00 54.71 ? 248 GLU A OE2   1 
ATOM   1428 N  N     . LYS A 1 249 ? 128.363 136.550 96.949  1.00 53.68 ? 249 LYS A N     1 
ATOM   1429 C  CA    . LYS A 1 249 ? 127.285 137.509 96.733  1.00 53.68 ? 249 LYS A CA    1 
ATOM   1430 C  C     . LYS A 1 249 ? 126.205 137.441 97.802  1.00 53.68 ? 249 LYS A C     1 
ATOM   1431 O  O     . LYS A 1 249 ? 125.278 138.257 97.768  1.00 53.68 ? 249 LYS A O     1 
ATOM   1432 C  CB    . LYS A 1 249 ? 126.645 137.299 95.359  1.00 53.68 ? 249 LYS A CB    1 
ATOM   1433 C  CG    . LYS A 1 249 ? 127.590 137.503 94.189  1.00 53.68 ? 249 LYS A CG    1 
ATOM   1434 C  CD    . LYS A 1 249 ? 128.010 138.956 94.076  1.00 53.68 ? 249 LYS A CD    1 
ATOM   1435 C  CE    . LYS A 1 249 ? 128.891 139.182 92.864  1.00 53.68 ? 249 LYS A CE    1 
ATOM   1436 N  NZ    . LYS A 1 249 ? 129.343 140.595 92.767  1.00 53.68 ? 249 LYS A NZ    1 
ATOM   1437 N  N     . ASN A 1 250 ? 126.300 136.490 98.733  1.00 50.90 ? 250 ASN A N     1 
ATOM   1438 C  CA    . ASN A 1 250 ? 125.322 136.301 99.806  1.00 50.90 ? 250 ASN A CA    1 
ATOM   1439 C  C     . ASN A 1 250 ? 123.936 135.978 99.242  1.00 50.90 ? 250 ASN A C     1 
ATOM   1440 O  O     . ASN A 1 250 ? 122.957 136.696 99.456  1.00 50.90 ? 250 ASN A O     1 
ATOM   1441 C  CB    . ASN A 1 250 ? 125.267 137.520 100.732 1.00 50.90 ? 250 ASN A CB    1 
ATOM   1442 C  CG    . ASN A 1 250 ? 125.114 137.138 102.190 1.00 50.90 ? 250 ASN A CG    1 
ATOM   1443 O  OD1   . ASN A 1 250 ? 125.247 135.970 102.557 1.00 50.90 ? 250 ASN A OD1   1 
ATOM   1444 N  ND2   . ASN A 1 250 ? 124.817 138.122 103.030 1.00 50.90 ? 250 ASN A ND2   1 
ATOM   1445 N  N     . TYR A 1 251 ? 123.871 134.866 98.511  1.00 45.34 ? 251 TYR A N     1 
ATOM   1446 C  CA    . TYR A 1 251 ? 122.604 134.343 98.032  1.00 45.34 ? 251 TYR A CA    1 
ATOM   1447 C  C     . TYR A 1 251 ? 122.315 132.923 98.487  1.00 45.34 ? 251 TYR A C     1 
ATOM   1448 O  O     . TYR A 1 251 ? 121.158 132.619 98.781  1.00 45.34 ? 251 TYR A O     1 
ATOM   1449 C  CB    . TYR A 1 251 ? 122.539 134.377 96.497  1.00 45.34 ? 251 TYR A CB    1 
ATOM   1450 C  CG    . TYR A 1 251 ? 121.145 134.147 95.963  1.00 45.34 ? 251 TYR A CG    1 
ATOM   1451 C  CD1   . TYR A 1 251 ? 120.219 135.175 95.922  1.00 45.34 ? 251 TYR A CD1   1 
ATOM   1452 C  CD2   . TYR A 1 251 ? 120.743 132.891 95.541  1.00 45.34 ? 251 TYR A CD2   1 
ATOM   1453 C  CE1   . TYR A 1 251 ? 118.941 134.965 95.447  1.00 45.34 ? 251 TYR A CE1   1 
ATOM   1454 C  CE2   . TYR A 1 251 ? 119.468 132.671 95.073  1.00 45.34 ? 251 TYR A CE2   1 
ATOM   1455 C  CZ    . TYR A 1 251 ? 118.571 133.710 95.026  1.00 45.34 ? 251 TYR A CZ    1 
ATOM   1456 O  OH    . TYR A 1 251 ? 117.298 133.492 94.558  1.00 45.34 ? 251 TYR A OH    1 
ATOM   1457 N  N     . GLY A 1 252 ? 123.313 132.049 98.547  1.00 39.00 ? 252 GLY A N     1 
ATOM   1458 C  CA    . GLY A 1 252 ? 123.064 130.666 98.901  1.00 39.00 ? 252 GLY A CA    1 
ATOM   1459 C  C     . GLY A 1 252 ? 122.442 129.917 97.744  1.00 39.00 ? 252 GLY A C     1 
ATOM   1460 O  O     . GLY A 1 252 ? 121.511 130.415 97.106  1.00 39.00 ? 252 GLY A O     1 
ATOM   1461 N  N     . LEU A 1 253 ? 122.919 128.709 97.473  1.00 41.49 ? 253 LEU A N     1 
ATOM   1462 C  CA    . LEU A 1 253 ? 122.549 127.979 96.270  1.00 41.49 ? 253 LEU A CA    1 
ATOM   1463 C  C     . LEU A 1 253 ? 121.478 126.947 96.590  1.00 41.49 ? 253 LEU A C     1 
ATOM   1464 O  O     . LEU A 1 253 ? 121.614 126.179 97.548  1.00 41.49 ? 253 LEU A O     1 
ATOM   1465 C  CB    . LEU A 1 253 ? 123.770 127.301 95.648  1.00 41.49 ? 253 LEU A CB    1 
ATOM   1466 C  CG    . LEU A 1 253 ? 123.515 126.470 94.393  1.00 41.49 ? 253 LEU A CG    1 
ATOM   1467 C  CD1   . LEU A 1 253 ? 122.764 127.282 93.354  1.00 41.49 ? 253 LEU A CD1   1 
ATOM   1468 C  CD2   . LEU A 1 253 ? 124.820 125.945 93.829  1.00 41.49 ? 253 LEU A CD2   1 
ATOM   1469 N  N     . GLY A 1 254 ? 120.414 126.942 95.787  1.00 41.27 ? 254 GLY A N     1 
ATOM   1470 C  CA    . GLY A 1 254 ? 119.388 125.932 95.889  1.00 41.27 ? 254 GLY A CA    1 
ATOM   1471 C  C     . GLY A 1 254 ? 119.081 125.362 94.519  1.00 41.27 ? 254 GLY A C     1 
ATOM   1472 O  O     . GLY A 1 254 ? 119.453 125.927 93.491  1.00 41.27 ? 254 GLY A O     1 
ATOM   1473 N  N     . TRP A 1 255 ? 118.394 124.216 94.518  1.00 43.60 ? 255 TRP A N     1 
ATOM   1474 C  CA    . TRP A 1 255 ? 118.098 123.550 93.254  1.00 43.60 ? 255 TRP A CA    1 
ATOM   1475 C  C     . TRP A 1 255 ? 117.191 124.400 92.381  1.00 43.60 ? 255 TRP A C     1 
ATOM   1476 O  O     . TRP A 1 255 ? 117.378 124.465 91.163  1.00 43.60 ? 255 TRP A O     1 
ATOM   1477 C  CB    . TRP A 1 255 ? 117.457 122.184 93.484  1.00 43.60 ? 255 TRP A CB    1 
ATOM   1478 C  CG    . TRP A 1 255 ? 116.676 121.715 92.287  1.00 43.60 ? 255 TRP A CG    1 
ATOM   1479 C  CD1   . TRP A 1 255 ? 115.329 121.525 92.209  1.00 43.60 ? 255 TRP A CD1   1 
ATOM   1480 C  CD2   . TRP A 1 255 ? 117.197 121.410 90.986  1.00 43.60 ? 255 TRP A CD2   1 
ATOM   1481 N  NE1   . TRP A 1 255 ? 114.980 121.107 90.949  1.00 43.60 ? 255 TRP A NE1   1 
ATOM   1482 C  CE2   . TRP A 1 255 ? 116.110 121.030 90.179  1.00 43.60 ? 255 TRP A CE2   1 
ATOM   1483 C  CE3   . TRP A 1 255 ? 118.479 121.417 90.428  1.00 43.60 ? 255 TRP A CE3   1 
ATOM   1484 C  CZ2   . TRP A 1 255 ? 116.264 120.660 88.849  1.00 43.60 ? 255 TRP A CZ2   1 
ATOM   1485 C  CZ3   . TRP A 1 255 ? 118.628 121.049 89.108  1.00 43.60 ? 255 TRP A CZ3   1 
ATOM   1486 C  CH2   . TRP A 1 255 ? 117.529 120.677 88.333  1.00 43.60 ? 255 TRP A CH2   1 
ATOM   1487 N  N     . TYR A 1 256 ? 116.191 125.046 92.979  1.00 44.41 ? 256 TYR A N     1 
ATOM   1488 C  CA    . TYR A 1 256 ? 115.271 125.841 92.177  1.00 44.41 ? 256 TYR A CA    1 
ATOM   1489 C  C     . TYR A 1 256 ? 116.002 126.967 91.459  1.00 44.41 ? 256 TYR A C     1 
ATOM   1490 O  O     . TYR A 1 256 ? 115.761 127.214 90.272  1.00 44.41 ? 256 TYR A O     1 
ATOM   1491 C  CB    . TYR A 1 256 ? 114.154 126.408 93.045  1.00 44.41 ? 256 TYR A CB    1 
ATOM   1492 C  CG    . TYR A 1 256 ? 113.353 127.473 92.340  1.00 44.41 ? 256 TYR A CG    1 
ATOM   1493 C  CD1   . TYR A 1 256 ? 112.450 127.139 91.348  1.00 44.41 ? 256 TYR A CD1   1 
ATOM   1494 C  CD2   . TYR A 1 256 ? 113.510 128.812 92.657  1.00 44.41 ? 256 TYR A CD2   1 
ATOM   1495 C  CE1   . TYR A 1 256 ? 111.719 128.103 90.699  1.00 44.41 ? 256 TYR A CE1   1 
ATOM   1496 C  CE2   . TYR A 1 256 ? 112.783 129.784 92.013  1.00 44.41 ? 256 TYR A CE2   1 
ATOM   1497 C  CZ    . TYR A 1 256 ? 111.888 129.424 91.034  1.00 44.41 ? 256 TYR A CZ    1 
ATOM   1498 O  OH    . TYR A 1 256 ? 111.156 130.390 90.383  1.00 44.41 ? 256 TYR A OH    1 
ATOM   1499 N  N     . VAL A 1 257 ? 116.897 127.661 92.161  1.00 44.88 ? 257 VAL A N     1 
ATOM   1500 C  CA    . VAL A 1 257 ? 117.622 128.767 91.546  1.00 44.88 ? 257 VAL A CA    1 
ATOM   1501 C  C     . VAL A 1 257 ? 118.537 128.254 90.445  1.00 44.88 ? 257 VAL A C     1 
ATOM   1502 O  O     . VAL A 1 257 ? 118.609 128.841 89.364  1.00 44.88 ? 257 VAL A O     1 
ATOM   1503 C  CB    . VAL A 1 257 ? 118.401 129.561 92.607  1.00 44.88 ? 257 VAL A CB    1 
ATOM   1504 C  CG1   . VAL A 1 257 ? 119.256 130.622 91.944  1.00 44.88 ? 257 VAL A CG1   1 
ATOM   1505 C  CG2   . VAL A 1 257 ? 117.437 130.199 93.583  1.00 44.88 ? 257 VAL A CG2   1 
ATOM   1506 N  N     . LEU A 1 258 ? 119.237 127.146 90.693  1.00 46.81 ? 258 LEU A N     1 
ATOM   1507 C  CA    . LEU A 1 258 ? 120.107 126.574 89.668  1.00 46.81 ? 258 LEU A CA    1 
ATOM   1508 C  C     . LEU A 1 258 ? 119.316 126.215 88.416  1.00 46.81 ? 258 LEU A C     1 
ATOM   1509 O  O     . LEU A 1 258 ? 119.675 126.611 87.301  1.00 46.81 ? 258 LEU A O     1 
ATOM   1510 C  CB    . LEU A 1 258 ? 120.817 125.341 90.224  1.00 46.81 ? 258 LEU A CB    1 
ATOM   1511 C  CG    . LEU A 1 258 ? 121.785 124.612 89.295  1.00 46.81 ? 258 LEU A CG    1 
ATOM   1512 C  CD1   . LEU A 1 258 ? 122.939 125.515 88.898  1.00 46.81 ? 258 LEU A CD1   1 
ATOM   1513 C  CD2   . LEU A 1 258 ? 122.296 123.342 89.953  1.00 46.81 ? 258 LEU A CD2   1 
ATOM   1514 N  N     . TRP A 1 259 ? 118.214 125.486 88.594  1.00 47.77 ? 259 TRP A N     1 
ATOM   1515 C  CA    . TRP A 1 259 ? 117.389 125.055 87.472  1.00 47.77 ? 259 TRP A CA    1 
ATOM   1516 C  C     . TRP A 1 259 ? 116.823 126.239 86.702  1.00 47.77 ? 259 TRP A C     1 
ATOM   1517 O  O     . TRP A 1 259 ? 116.955 126.314 85.474  1.00 47.77 ? 259 TRP A O     1 
ATOM   1518 C  CB    . TRP A 1 259 ? 116.273 124.151 87.995  1.00 47.77 ? 259 TRP A CB    1 
ATOM   1519 C  CG    . TRP A 1 259 ? 115.090 124.024 87.100  1.00 47.77 ? 259 TRP A CG    1 
ATOM   1520 C  CD1   . TRP A 1 259 ? 115.072 123.582 85.810  1.00 47.77 ? 259 TRP A CD1   1 
ATOM   1521 C  CD2   . TRP A 1 259 ? 113.731 124.310 87.445  1.00 47.77 ? 259 TRP A CD2   1 
ATOM   1522 N  NE1   . TRP A 1 259 ? 113.786 123.596 85.324  1.00 47.77 ? 259 TRP A NE1   1 
ATOM   1523 C  CE2   . TRP A 1 259 ? 112.945 124.037 86.312  1.00 47.77 ? 259 TRP A CE2   1 
ATOM   1524 C  CE3   . TRP A 1 259 ? 113.105 124.777 88.603  1.00 47.77 ? 259 TRP A CE3   1 
ATOM   1525 C  CZ2   . TRP A 1 259 ? 111.567 124.219 86.301  1.00 47.77 ? 259 TRP A CZ2   1 
ATOM   1526 C  CZ3   . TRP A 1 259 ? 111.740 124.954 88.591  1.00 47.77 ? 259 TRP A CZ3   1 
ATOM   1527 C  CH2   . TRP A 1 259 ? 110.984 124.678 87.449  1.00 47.77 ? 259 TRP A CH2   1 
ATOM   1528 N  N     . GLN A 1 260 ? 116.203 127.188 87.403  1.00 50.45 ? 260 GLN A N     1 
ATOM   1529 C  CA    . GLN A 1 260 ? 115.550 128.289 86.707  1.00 50.45 ? 260 GLN A CA    1 
ATOM   1530 C  C     . GLN A 1 260 ? 116.566 129.255 86.106  1.00 50.45 ? 260 GLN A C     1 
ATOM   1531 O  O     . GLN A 1 260 ? 116.305 129.843 85.052  1.00 50.45 ? 260 GLN A O     1 
ATOM   1532 C  CB    . GLN A 1 260 ? 114.600 129.017 87.657  1.00 50.45 ? 260 GLN A CB    1 
ATOM   1533 C  CG    . GLN A 1 260 ? 113.785 130.115 87.002  1.00 50.45 ? 260 GLN A CG    1 
ATOM   1534 C  CD    . GLN A 1 260 ? 112.868 129.590 85.921  1.00 50.45 ? 260 GLN A CD    1 
ATOM   1535 O  OE1   . GLN A 1 260 ? 113.137 129.749 84.731  1.00 50.45 ? 260 GLN A OE1   1 
ATOM   1536 N  NE2   . GLN A 1 260 ? 111.770 128.967 86.330  1.00 50.45 ? 260 GLN A NE2   1 
ATOM   1537 N  N     . GLY A 1 261 ? 117.728 129.424 86.741  1.00 53.00 ? 261 GLY A N     1 
ATOM   1538 C  CA    . GLY A 1 261 ? 118.766 130.254 86.160  1.00 53.00 ? 261 GLY A CA    1 
ATOM   1539 C  C     . GLY A 1 261 ? 119.372 129.640 84.916  1.00 53.00 ? 261 GLY A C     1 
ATOM   1540 O  O     . GLY A 1 261 ? 119.676 130.348 83.954  1.00 53.00 ? 261 GLY A O     1 
ATOM   1541 N  N     . VAL A 1 262 ? 119.568 128.319 84.916  1.00 54.92 ? 262 VAL A N     1 
ATOM   1542 C  CA    . VAL A 1 262 ? 120.008 127.646 83.698  1.00 54.92 ? 262 VAL A CA    1 
ATOM   1543 C  C     . VAL A 1 262 ? 118.956 127.798 82.608  1.00 54.92 ? 262 VAL A C     1 
ATOM   1544 O  O     . VAL A 1 262 ? 119.280 128.061 81.444  1.00 54.92 ? 262 VAL A O     1 
ATOM   1545 C  CB    . VAL A 1 262 ? 120.323 126.167 83.986  1.00 54.92 ? 262 VAL A CB    1 
ATOM   1546 C  CG1   . VAL A 1 262 ? 120.454 125.386 82.691  1.00 54.92 ? 262 VAL A CG1   1 
ATOM   1547 C  CG2   . VAL A 1 262 ? 121.592 126.050 84.803  1.00 54.92 ? 262 VAL A CG2   1 
ATOM   1548 N  N     . LYS A 1 263 ? 117.681 127.647 82.971  1.00 56.85 ? 263 LYS A N     1 
ATOM   1549 C  CA    . LYS A 1 263 ? 116.604 127.789 81.998  1.00 56.85 ? 263 LYS A CA    1 
ATOM   1550 C  C     . LYS A 1 263 ? 116.582 129.186 81.387  1.00 56.85 ? 263 LYS A C     1 
ATOM   1551 O  O     . LYS A 1 263 ? 116.502 129.337 80.162  1.00 56.85 ? 263 LYS A O     1 
ATOM   1552 C  CB    . LYS A 1 263 ? 115.264 127.478 82.665  1.00 56.85 ? 263 LYS A CB    1 
ATOM   1553 C  CG    . LYS A 1 263 ? 114.056 127.582 81.751  1.00 56.85 ? 263 LYS A CG    1 
ATOM   1554 C  CD    . LYS A 1 263 ? 114.095 126.534 80.662  1.00 56.85 ? 263 LYS A CD    1 
ATOM   1555 C  CE    . LYS A 1 263 ? 113.946 125.145 81.254  1.00 56.85 ? 263 LYS A CE    1 
ATOM   1556 N  NZ    . LYS A 1 263 ? 112.589 124.939 81.831  1.00 56.85 ? 263 LYS A NZ    1 
ATOM   1557 N  N     . GLN A 1 264 ? 116.658 130.222 82.225  1.00 61.31 ? 264 GLN A N     1 
ATOM   1558 C  CA    . GLN A 1 264 ? 116.515 131.601 81.773  1.00 61.31 ? 264 GLN A CA    1 
ATOM   1559 C  C     . GLN A 1 264 ? 117.818 132.211 81.280  1.00 61.31 ? 264 GLN A C     1 
ATOM   1560 O  O     . GLN A 1 264 ? 117.800 133.333 80.767  1.00 61.31 ? 264 GLN A O     1 
ATOM   1561 C  CB    . GLN A 1 264 ? 115.949 132.468 82.899  1.00 61.31 ? 264 GLN A CB    1 
ATOM   1562 C  CG    . GLN A 1 264 ? 114.441 132.616 82.877  1.00 61.31 ? 264 GLN A CG    1 
ATOM   1563 C  CD    . GLN A 1 264 ? 113.951 133.656 83.864  1.00 61.31 ? 264 GLN A CD    1 
ATOM   1564 O  OE1   . GLN A 1 264 ? 114.741 134.262 84.587  1.00 61.31 ? 264 GLN A OE1   1 
ATOM   1565 N  NE2   . GLN A 1 264 ? 112.640 133.865 83.903  1.00 61.31 ? 264 GLN A NE2   1 
ATOM   1566 N  N     . ALA A 1 265 ? 118.944 131.519 81.440  1.00 62.46 ? 265 ALA A N     1 
ATOM   1567 C  CA    . ALA A 1 265 ? 120.195 132.016 80.885  1.00 62.46 ? 265 ALA A CA    1 
ATOM   1568 C  C     . ALA A 1 265 ? 120.189 131.922 79.367  1.00 62.46 ? 265 ALA A C     1 
ATOM   1569 O  O     . ALA A 1 265 ? 120.854 132.709 78.684  1.00 62.46 ? 265 ALA A O     1 
ATOM   1570 C  CB    . ALA A 1 265 ? 121.371 131.237 81.471  1.00 62.46 ? 265 ALA A CB    1 
ATOM   1571 N  N     . LEU A 1 266 ? 119.438 130.963 78.824  1.00 64.79 ? 266 LEU A N     1 
ATOM   1572 C  CA    . LEU A 1 266 ? 119.374 130.747 77.387  1.00 64.79 ? 266 LEU A CA    1 
ATOM   1573 C  C     . LEU A 1 266 ? 118.548 131.804 76.667  1.00 64.79 ? 266 LEU A C     1 
ATOM   1574 O  O     . LEU A 1 266 ? 118.724 131.983 75.458  1.00 64.79 ? 266 LEU A O     1 
ATOM   1575 C  CB    . LEU A 1 266 ? 118.805 129.356 77.111  1.00 64.79 ? 266 LEU A CB    1 
ATOM   1576 C  CG    . LEU A 1 266 ? 119.670 128.211 77.643  1.00 64.79 ? 266 LEU A CG    1 
ATOM   1577 C  CD1   . LEU A 1 266 ? 118.974 126.875 77.462  1.00 64.79 ? 266 LEU A CD1   1 
ATOM   1578 C  CD2   . LEU A 1 266 ? 121.023 128.205 76.956  1.00 64.79 ? 266 LEU A CD2   1 
ATOM   1579 N  N     . LYS A 1 267 ? 117.665 132.505 77.372  1.00 76.17 ? 267 LYS A N     1 
ATOM   1580 C  CA    . LYS A 1 267 ? 116.840 133.554 76.791  1.00 76.17 ? 267 LYS A CA    1 
ATOM   1581 C  C     . LYS A 1 267 ? 117.148 134.871 77.488  1.00 76.17 ? 267 LYS A C     1 
ATOM   1582 O  O     . LYS A 1 267 ? 117.067 134.959 78.717  1.00 76.17 ? 267 LYS A O     1 
ATOM   1583 C  CB    . LYS A 1 267 ? 115.351 133.220 76.923  1.00 76.17 ? 267 LYS A CB    1 
ATOM   1584 C  CG    . LYS A 1 267 ? 114.819 132.303 75.835  1.00 76.17 ? 267 LYS A CG    1 
ATOM   1585 C  CD    . LYS A 1 267 ? 115.078 130.841 76.161  1.00 76.17 ? 267 LYS A CD    1 
ATOM   1586 C  CE    . LYS A 1 267 ? 114.553 129.931 75.060  1.00 76.17 ? 267 LYS A CE    1 
ATOM   1587 N  NZ    . LYS A 1 267 ? 114.961 128.512 75.260  1.00 76.17 ? 267 LYS A NZ    1 
ATOM   1588 N  N     . GLU A 1 268 ? 117.488 135.891 76.707  1.00 86.82 ? 268 GLU A N     1 
ATOM   1589 C  CA    . GLU A 1 268 ? 117.832 137.181 77.286  1.00 86.82 ? 268 GLU A CA    1 
ATOM   1590 C  C     . GLU A 1 268 ? 116.605 137.827 77.921  1.00 86.82 ? 268 GLU A C     1 
ATOM   1591 O  O     . GLU A 1 268 ? 115.494 137.750 77.388  1.00 86.82 ? 268 GLU A O     1 
ATOM   1592 C  CB    . GLU A 1 268 ? 118.432 138.100 76.223  1.00 86.82 ? 268 GLU A CB    1 
ATOM   1593 C  CG    . GLU A 1 268 ? 119.375 139.146 76.788  1.00 86.82 ? 268 GLU A CG    1 
ATOM   1594 C  CD    . GLU A 1 268 ? 118.652 140.409 77.198  1.00 86.82 ? 268 GLU A CD    1 
ATOM   1595 O  OE1   . GLU A 1 268 ? 117.562 140.668 76.646  1.00 86.82 ? 268 GLU A OE1   1 
ATOM   1596 O  OE2   . GLU A 1 268 ? 119.164 141.136 78.075  1.00 86.82 ? 268 GLU A OE2   1 
ATOM   1597 N  N     . GLN A 1 269 ? 116.815 138.469 79.065  1.00 84.73 ? 269 GLN A N     1 
ATOM   1598 C  CA    . GLN A 1 269 ? 115.737 139.009 79.881  1.00 84.73 ? 269 GLN A CA    1 
ATOM   1599 C  C     . GLN A 1 269 ? 115.353 140.414 79.433  1.00 84.73 ? 269 GLN A C     1 
ATOM   1600 O  O     . GLN A 1 269 ? 116.173 141.168 78.906  1.00 84.73 ? 269 GLN A O     1 
ATOM   1601 C  CB    . GLN A 1 269 ? 116.139 139.033 81.356  1.00 84.73 ? 269 GLN A CB    1 
ATOM   1602 C  CG    . GLN A 1 269 ? 117.298 139.966 81.659  1.00 84.73 ? 269 GLN A CG    1 
ATOM   1603 C  CD    . GLN A 1 269 ? 117.229 140.546 83.055  1.00 84.73 ? 269 GLN A CD    1 
ATOM   1604 O  OE1   . GLN A 1 269 ? 116.145 140.793 83.584  1.00 84.73 ? 269 GLN A OE1   1 
ATOM   1605 N  NE2   . GLN A 1 269 ? 118.390 140.761 83.664  1.00 84.73 ? 269 GLN A NE2   1 
ATOM   1606 N  N     . LYS A 1 270 ? 114.088 140.762 79.666  1.00 84.78 ? 270 LYS A N     1 
ATOM   1607 C  CA    . LYS A 1 270 ? 113.557 142.072 79.315  1.00 84.78 ? 270 LYS A CA    1 
ATOM   1608 C  C     . LYS A 1 270 ? 113.277 142.915 80.552  1.00 84.78 ? 270 LYS A C     1 
ATOM   1609 O  O     . LYS A 1 270 ? 113.797 144.027 80.679  1.00 84.78 ? 270 LYS A O     1 
ATOM   1610 C  CB    . LYS A 1 270 ? 112.281 141.911 78.475  1.00 84.78 ? 270 LYS A CB    1 
ATOM   1611 C  CG    . LYS A 1 270 ? 112.521 141.791 76.974  1.00 84.78 ? 270 LYS A CG    1 
ATOM   1612 C  CD    . LYS A 1 270 ? 113.226 140.490 76.615  1.00 84.78 ? 270 LYS A CD    1 
ATOM   1613 C  CE    . LYS A 1 270 ? 112.470 139.283 77.144  1.00 84.78 ? 270 LYS A CE    1 
ATOM   1614 N  NZ    . LYS A 1 270 ? 113.188 138.013 76.857  1.00 84.78 ? 270 LYS A NZ    1 
ATOM   1615 N  N     . LYS A 1 271 ? 112.471 142.409 81.471  1.00 79.37 ? 271 LYS A N     1 
ATOM   1616 C  CA    . LYS A 1 271 ? 112.193 143.043 82.746  1.00 79.37 ? 271 LYS A CA    1 
ATOM   1617 C  C     . LYS A 1 271 ? 112.870 142.278 83.871  1.00 79.37 ? 271 LYS A C     1 
ATOM   1618 O  O     . LYS A 1 271 ? 113.218 141.103 83.715  1.00 79.37 ? 271 LYS A O     1 
ATOM   1619 C  CB    . LYS A 1 271 ? 110.681 143.108 82.993  1.00 79.37 ? 271 LYS A CB    1 
ATOM   1620 C  CG    . LYS A 1 271 ? 109.947 144.096 82.099  1.00 79.37 ? 271 LYS A CG    1 
ATOM   1621 C  CD    . LYS A 1 271 ? 108.439 143.981 82.263  1.00 79.37 ? 271 LYS A CD    1 
ATOM   1622 C  CE    . LYS A 1 271 ? 107.897 142.738 81.575  1.00 79.37 ? 271 LYS A CE    1 
ATOM   1623 N  NZ    . LYS A 1 271 ? 108.119 142.775 80.103  1.00 79.37 ? 271 LYS A NZ    1 
ATOM   1624 N  N     . PRO A 1 272 ? 113.099 142.919 85.018  1.00 73.85 ? 272 PRO A N     1 
ATOM   1625 C  CA    . PRO A 1 272 ? 113.681 142.197 86.156  1.00 73.85 ? 272 PRO A CA    1 
ATOM   1626 C  C     . PRO A 1 272 ? 112.809 141.018 86.567  1.00 73.85 ? 272 PRO A C     1 
ATOM   1627 O  O     . PRO A 1 272 ? 111.581 141.069 86.483  1.00 73.85 ? 272 PRO A O     1 
ATOM   1628 C  CB    . PRO A 1 272 ? 113.759 143.262 87.259  1.00 73.85 ? 272 PRO A CB    1 
ATOM   1629 C  CG    . PRO A 1 272 ? 112.938 144.419 86.768  1.00 73.85 ? 272 PRO A CG    1 
ATOM   1630 C  CD    . PRO A 1 272 ? 112.986 144.362 85.282  1.00 73.85 ? 272 PRO A CD    1 
ATOM   1631 N  N     . THR A 1 273 ? 113.465 139.947 87.007  1.00 67.64 ? 273 THR A N     1 
ATOM   1632 C  CA    . THR A 1 273 ? 112.832 138.659 87.240  1.00 67.64 ? 273 THR A CA    1 
ATOM   1633 C  C     . THR A 1 273 ? 112.964 138.313 88.719  1.00 67.64 ? 273 THR A C     1 
ATOM   1634 O  O     . THR A 1 273 ? 113.787 138.890 89.435  1.00 67.64 ? 273 THR A O     1 
ATOM   1635 C  CB    . THR A 1 273 ? 113.482 137.573 86.351  1.00 67.64 ? 273 THR A CB    1 
ATOM   1636 O  OG1   . THR A 1 273 ? 113.453 138.001 84.985  1.00 67.64 ? 273 THR A OG1   1 
ATOM   1637 C  CG2   . THR A 1 273 ? 112.735 136.250 86.434  1.00 67.64 ? 273 THR A CG2   1 
ATOM   1638 N  N     . LYS A 1 274 ? 112.134 137.367 89.176  1.00 59.35 ? 274 LYS A N     1 
ATOM   1639 C  CA    . LYS A 1 274 ? 112.221 136.882 90.552  1.00 59.35 ? 274 LYS A CA    1 
ATOM   1640 C  C     . LYS A 1 274 ? 113.650 136.503 90.919  1.00 59.35 ? 274 LYS A C     1 
ATOM   1641 O  O     . LYS A 1 274 ? 114.050 136.611 92.081  1.00 59.35 ? 274 LYS A O     1 
ATOM   1642 C  CB    . LYS A 1 274 ? 111.286 135.685 90.747  1.00 59.35 ? 274 LYS A CB    1 
ATOM   1643 C  CG    . LYS A 1 274 ? 109.803 136.029 90.768  1.00 59.35 ? 274 LYS A CG    1 
ATOM   1644 C  CD    . LYS A 1 274 ? 109.429 136.766 92.043  1.00 59.35 ? 274 LYS A CD    1 
ATOM   1645 C  CE    . LYS A 1 274 ? 109.591 135.869 93.263  1.00 59.35 ? 274 LYS A CE    1 
ATOM   1646 N  NZ    . LYS A 1 274 ? 109.402 136.609 94.544  1.00 59.35 ? 274 LYS A NZ    1 
ATOM   1647 N  N     . ILE A 1 275 ? 114.427 136.038 89.947  1.00 60.36 ? 275 ILE A N     1 
ATOM   1648 C  CA    . ILE A 1 275 ? 115.861 135.836 90.107  1.00 60.36 ? 275 ILE A CA    1 
ATOM   1649 C  C     . ILE A 1 275 ? 116.559 136.689 89.060  1.00 60.36 ? 275 ILE A C     1 
ATOM   1650 O  O     . ILE A 1 275 ? 116.251 136.595 87.865  1.00 60.36 ? 275 ILE A O     1 
ATOM   1651 C  CB    . ILE A 1 275 ? 116.254 134.359 89.965  1.00 60.36 ? 275 ILE A CB    1 
ATOM   1652 C  CG1   . ILE A 1 275 ? 115.515 133.716 88.793  1.00 60.36 ? 275 ILE A CG1   1 
ATOM   1653 C  CG2   . ILE A 1 275 ? 115.960 133.607 91.252  1.00 60.36 ? 275 ILE A CG2   1 
ATOM   1654 C  CD1   . ILE A 1 275 ? 116.031 132.352 88.454  1.00 60.36 ? 275 ILE A CD1   1 
ATOM   1655 N  N     . GLN A 1 276 ? 117.475 137.545 89.505  1.00 65.39 ? 276 GLN A N     1 
ATOM   1656 C  CA    . GLN A 1 276 ? 118.234 138.398 88.601  1.00 65.39 ? 276 GLN A CA    1 
ATOM   1657 C  C     . GLN A 1 276 ? 119.737 138.253 88.768  1.00 65.39 ? 276 GLN A C     1 
ATOM   1658 O  O     . GLN A 1 276 ? 120.461 138.200 87.770  1.00 65.39 ? 276 GLN A O     1 
ATOM   1659 C  CB    . GLN A 1 276 ? 117.815 139.862 88.789  1.00 65.39 ? 276 GLN A CB    1 
ATOM   1660 C  CG    . GLN A 1 276 ? 116.597 140.239 87.968  1.00 65.39 ? 276 GLN A CG    1 
ATOM   1661 C  CD    . GLN A 1 276 ? 116.875 140.182 86.481  1.00 65.39 ? 276 GLN A CD    1 
ATOM   1662 O  OE1   . GLN A 1 276 ? 117.903 140.670 86.014  1.00 65.39 ? 276 GLN A OE1   1 
ATOM   1663 N  NE2   . GLN A 1 276 ? 115.967 139.577 85.730  1.00 65.39 ? 276 GLN A NE2   1 
ATOM   1664 N  N     . ILE A 1 277 ? 120.232 138.195 90.005  1.00 61.73 ? 277 ILE A N     1 
ATOM   1665 C  CA    . ILE A 1 277 ? 121.673 138.102 90.222  1.00 61.73 ? 277 ILE A CA    1 
ATOM   1666 C  C     . ILE A 1 277 ? 122.216 136.796 89.659  1.00 61.73 ? 277 ILE A C     1 
ATOM   1667 O  O     . ILE A 1 277 ? 123.296 136.764 89.057  1.00 61.73 ? 277 ILE A O     1 
ATOM   1668 C  CB    . ILE A 1 277 ? 121.998 138.263 91.719  1.00 61.73 ? 277 ILE A CB    1 
ATOM   1669 C  CG1   . ILE A 1 277 ? 121.748 139.706 92.158  1.00 61.73 ? 277 ILE A CG1   1 
ATOM   1670 C  CG2   . ILE A 1 277 ? 123.432 137.858 92.013  1.00 61.73 ? 277 ILE A CG2   1 
ATOM   1671 C  CD1   . ILE A 1 277 ? 121.967 139.940 93.629  1.00 61.73 ? 277 ILE A CD1   1 
ATOM   1672 N  N     . ALA A 1 278 ? 121.472 135.701 89.830  1.00 61.90 ? 278 ALA A N     1 
ATOM   1673 C  CA    . ALA A 1 278 ? 121.944 134.403 89.357  1.00 61.90 ? 278 ALA A CA    1 
ATOM   1674 C  C     . ALA A 1 278 ? 122.048 134.368 87.835  1.00 61.90 ? 278 ALA A C     1 
ATOM   1675 O  O     . ALA A 1 278 ? 123.068 133.942 87.280  1.00 61.90 ? 278 ALA A O     1 
ATOM   1676 C  CB    . ALA A 1 278 ? 121.018 133.298 89.865  1.00 61.90 ? 278 ALA A CB    1 
ATOM   1677 N  N     . VAL A 1 279 ? 120.999 134.818 87.141  1.00 62.03 ? 279 VAL A N     1 
ATOM   1678 C  CA    . VAL A 1 279 ? 121.014 134.783 85.681  1.00 62.03 ? 279 VAL A CA    1 
ATOM   1679 C  C     . VAL A 1 279 ? 122.059 135.749 85.132  1.00 62.03 ? 279 VAL A C     1 
ATOM   1680 O  O     . VAL A 1 279 ? 122.723 135.460 84.130  1.00 62.03 ? 279 VAL A O     1 
ATOM   1681 C  CB    . VAL A 1 279 ? 119.608 135.068 85.120  1.00 62.03 ? 279 VAL A CB    1 
ATOM   1682 C  CG1   . VAL A 1 279 ? 119.107 136.428 85.557  1.00 62.03 ? 279 VAL A CG1   1 
ATOM   1683 C  CG2   . VAL A 1 279 ? 119.611 134.967 83.607  1.00 62.03 ? 279 VAL A CG2   1 
ATOM   1684 N  N     . ASP A 1 280 ? 122.228 136.903 85.780  1.00 65.42 ? 280 ASP A N     1 
ATOM   1685 C  CA    . ASP A 1 280 ? 123.258 137.847 85.358  1.00 65.42 ? 280 ASP A CA    1 
ATOM   1686 C  C     . ASP A 1 280 ? 124.646 137.243 85.519  1.00 65.42 ? 280 ASP A C     1 
ATOM   1687 O  O     . ASP A 1 280 ? 125.511 137.402 84.650  1.00 65.42 ? 280 ASP A O     1 
ATOM   1688 C  CB    . ASP A 1 280 ? 123.139 139.145 86.157  1.00 65.42 ? 280 ASP A CB    1 
ATOM   1689 C  CG    . ASP A 1 280 ? 121.888 139.930 85.815  1.00 65.42 ? 280 ASP A CG    1 
ATOM   1690 O  OD1   . ASP A 1 280 ? 121.046 139.409 85.054  1.00 65.42 ? 280 ASP A OD1   1 
ATOM   1691 O  OD2   . ASP A 1 280 ? 121.743 141.067 86.312  1.00 65.42 ? 280 ASP A OD2   1 
ATOM   1692 N  N     . GLN A 1 281 ? 124.879 136.545 86.629  1.00 64.16 ? 281 GLN A N     1 
ATOM   1693 C  CA    . GLN A 1 281 ? 126.186 135.964 86.898  1.00 64.16 ? 281 GLN A CA    1 
ATOM   1694 C  C     . GLN A 1 281 ? 126.429 134.685 86.108  1.00 64.16 ? 281 GLN A C     1 
ATOM   1695 O  O     . GLN A 1 281 ? 127.574 134.231 86.019  1.00 64.16 ? 281 GLN A O     1 
ATOM   1696 C  CB    . GLN A 1 281 ? 126.331 135.709 88.403  1.00 64.16 ? 281 GLN A CB    1 
ATOM   1697 C  CG    . GLN A 1 281 ? 127.691 135.198 88.842  1.00 64.16 ? 281 GLN A CG    1 
ATOM   1698 C  CD    . GLN A 1 281 ? 128.800 136.184 88.536  1.00 64.16 ? 281 GLN A CD    1 
ATOM   1699 O  OE1   . GLN A 1 281 ? 129.574 135.993 87.600  1.00 64.16 ? 281 GLN A OE1   1 
ATOM   1700 N  NE2   . GLN A 1 281 ? 128.878 137.249 89.322  1.00 64.16 ? 281 GLN A NE2   1 
ATOM   1701 N  N     . LEU A 1 282 ? 125.388 134.100 85.519  1.00 63.50 ? 282 LEU A N     1 
ATOM   1702 C  CA    . LEU A 1 282 ? 125.563 132.929 84.669  1.00 63.50 ? 282 LEU A CA    1 
ATOM   1703 C  C     . LEU A 1 282 ? 125.984 133.284 83.247  1.00 63.50 ? 282 LEU A C     1 
ATOM   1704 O  O     . LEU A 1 282 ? 126.244 132.376 82.450  1.00 63.50 ? 282 LEU A O     1 
ATOM   1705 C  CB    . LEU A 1 282 ? 124.266 132.117 84.641  1.00 63.50 ? 282 LEU A CB    1 
ATOM   1706 C  CG    . LEU A 1 282 ? 124.068 131.099 85.767  1.00 63.50 ? 282 LEU A CG    1 
ATOM   1707 C  CD1   . LEU A 1 282 ? 122.645 130.567 85.763  1.00 63.50 ? 282 LEU A CD1   1 
ATOM   1708 C  CD2   . LEU A 1 282 ? 125.070 129.960 85.650  1.00 63.50 ? 282 LEU A CD2   1 
ATOM   1709 N  N     . ARG A 1 283 ? 126.062 134.576 82.913  1.00 65.31 ? 283 ARG A N     1 
ATOM   1710 C  CA    . ARG A 1 283 ? 126.339 134.987 81.540  1.00 65.31 ? 283 ARG A CA    1 
ATOM   1711 C  C     . ARG A 1 283 ? 127.805 134.810 81.167  1.00 65.31 ? 283 ARG A C     1 
ATOM   1712 O  O     . ARG A 1 283 ? 128.117 134.566 79.996  1.00 65.31 ? 283 ARG A O     1 
ATOM   1713 C  CB    . ARG A 1 283 ? 125.928 136.447 81.336  1.00 65.31 ? 283 ARG A CB    1 
ATOM   1714 C  CG    . ARG A 1 283 ? 124.463 136.748 81.624  1.00 65.31 ? 283 ARG A CG    1 
ATOM   1715 C  CD    . ARG A 1 283 ? 123.590 136.621 80.382  1.00 65.31 ? 283 ARG A CD    1 
ATOM   1716 N  NE    . ARG A 1 283 ? 123.685 135.307 79.758  1.00 65.31 ? 283 ARG A NE    1 
ATOM   1717 C  CZ    . ARG A 1 283 ? 123.278 134.175 80.317  1.00 65.31 ? 283 ARG A CZ    1 
ATOM   1718 N  NH1   . ARG A 1 283 ? 122.719 134.157 81.515  1.00 65.31 ? 283 ARG A NH1   1 
ATOM   1719 N  NH2   . ARG A 1 283 ? 123.435 133.033 79.655  1.00 65.31 ? 283 ARG A NH2   1 
ATOM   1720 N  N     . GLN A 1 284 ? 128.712 134.940 82.131  1.00 68.90 ? 284 GLN A N     1 
ATOM   1721 C  CA    . GLN A 1 284 ? 130.133 134.952 81.829  1.00 68.90 ? 284 GLN A CA    1 
ATOM   1722 C  C     . GLN A 1 284 ? 130.596 133.605 81.272  1.00 68.90 ? 284 GLN A C     1 
ATOM   1723 O  O     . GLN A 1 284 ? 130.015 132.562 81.582  1.00 68.90 ? 284 GLN A O     1 
ATOM   1724 C  CB    . GLN A 1 284 ? 130.936 135.317 83.075  1.00 68.90 ? 284 GLN A CB    1 
ATOM   1725 C  CG    . GLN A 1 284 ? 130.825 136.786 83.471  1.00 68.90 ? 284 GLN A CG    1 
ATOM   1726 C  CD    . GLN A 1 284 ? 129.550 137.108 84.220  1.00 68.90 ? 284 GLN A CD    1 
ATOM   1727 O  OE1   . GLN A 1 284 ? 128.873 136.218 84.725  1.00 68.90 ? 284 GLN A OE1   1 
ATOM   1728 N  NE2   . GLN A 1 284 ? 129.217 138.390 84.295  1.00 68.90 ? 284 GLN A NE2   1 
ATOM   1729 N  N     . PRO A 1 285 ? 131.636 133.608 80.432  1.00 72.64 ? 285 PRO A N     1 
ATOM   1730 C  CA    . PRO A 1 285 ? 132.060 132.361 79.769  1.00 72.64 ? 285 PRO A CA    1 
ATOM   1731 C  C     . PRO A 1 285 ? 132.547 131.279 80.716  1.00 72.64 ? 285 PRO A C     1 
ATOM   1732 O  O     . PRO A 1 285 ? 132.596 130.111 80.314  1.00 72.64 ? 285 PRO A O     1 
ATOM   1733 C  CB    . PRO A 1 285 ? 133.186 132.826 78.835  1.00 72.64 ? 285 PRO A CB    1 
ATOM   1734 C  CG    . PRO A 1 285 ? 132.939 134.283 78.635  1.00 72.64 ? 285 PRO A CG    1 
ATOM   1735 C  CD    . PRO A 1 285 ? 132.381 134.775 79.932  1.00 72.64 ? 285 PRO A CD    1 
ATOM   1736 N  N     . LYS A 1 286 ? 132.925 131.620 81.949  1.00 73.22 ? 286 LYS A N     1 
ATOM   1737 C  CA    . LYS A 1 286 ? 133.353 130.595 82.894  1.00 73.22 ? 286 LYS A CA    1 
ATOM   1738 C  C     . LYS A 1 286 ? 132.236 129.617 83.235  1.00 73.22 ? 286 LYS A C     1 
ATOM   1739 O  O     . LYS A 1 286 ? 132.522 128.501 83.679  1.00 73.22 ? 286 LYS A O     1 
ATOM   1740 C  CB    . LYS A 1 286 ? 133.885 131.242 84.174  1.00 73.22 ? 286 LYS A CB    1 
ATOM   1741 C  CG    . LYS A 1 286 ? 132.838 132.002 84.974  1.00 73.22 ? 286 LYS A CG    1 
ATOM   1742 C  CD    . LYS A 1 286 ? 133.481 132.766 86.120  1.00 73.22 ? 286 LYS A CD    1 
ATOM   1743 C  CE    . LYS A 1 286 ? 132.438 133.365 87.044  1.00 73.22 ? 286 LYS A CE    1 
ATOM   1744 N  NZ    . LYS A 1 286 ? 132.239 134.814 86.775  1.00 73.22 ? 286 LYS A NZ    1 
ATOM   1745 N  N     . PHE A 1 287 ? 130.977 130.007 83.035  1.00 69.49 ? 287 PHE A N     1 
ATOM   1746 C  CA    . PHE A 1 287 ? 129.835 129.139 83.283  1.00 69.49 ? 287 PHE A CA    1 
ATOM   1747 C  C     . PHE A 1 287 ? 129.275 128.534 82.001  1.00 69.49 ? 287 PHE A C     1 
ATOM   1748 O  O     . PHE A 1 287 ? 128.106 128.136 81.969  1.00 69.49 ? 287 PHE A O     1 
ATOM   1749 C  CB    . PHE A 1 287 ? 128.739 129.902 84.028  1.00 69.49 ? 287 PHE A CB    1 
ATOM   1750 C  CG    . PHE A 1 287 ? 129.071 130.187 85.465  1.00 69.49 ? 287 PHE A CG    1 
ATOM   1751 C  CD1   . PHE A 1 287 ? 129.974 129.392 86.151  1.00 69.49 ? 287 PHE A CD1   1 
ATOM   1752 C  CD2   . PHE A 1 287 ? 128.475 131.244 86.131  1.00 69.49 ? 287 PHE A CD2   1 
ATOM   1753 C  CE1   . PHE A 1 287 ? 130.283 129.651 87.470  1.00 69.49 ? 287 PHE A CE1   1 
ATOM   1754 C  CE2   . PHE A 1 287 ? 128.778 131.508 87.452  1.00 69.49 ? 287 PHE A CE2   1 
ATOM   1755 C  CZ    . PHE A 1 287 ? 129.684 130.710 88.121  1.00 69.49 ? 287 PHE A CZ    1 
ATOM   1756 N  N     . ALA A 1 288 ? 130.081 128.468 80.939  1.00 68.16 ? 288 ALA A N     1 
ATOM   1757 C  CA    . ALA A 1 288 ? 129.614 127.853 79.701  1.00 68.16 ? 288 ALA A CA    1 
ATOM   1758 C  C     . ALA A 1 288 ? 129.441 126.349 79.853  1.00 68.16 ? 288 ALA A C     1 
ATOM   1759 O  O     . ALA A 1 288 ? 128.655 125.740 79.119  1.00 68.16 ? 288 ALA A O     1 
ATOM   1760 C  CB    . ALA A 1 288 ? 130.579 128.164 78.558  1.00 68.16 ? 288 ALA A CB    1 
ATOM   1761 N  N     . GLY A 1 289 ? 130.166 125.734 80.789  1.00 64.27 ? 289 GLY A N     1 
ATOM   1762 C  CA    . GLY A 1 289 ? 130.014 124.305 81.006  1.00 64.27 ? 289 GLY A CA    1 
ATOM   1763 C  C     . GLY A 1 289 ? 128.645 123.935 81.543  1.00 64.27 ? 289 GLY A C     1 
ATOM   1764 O  O     . GLY A 1 289 ? 128.092 122.891 81.189  1.00 64.27 ? 289 GLY A O     1 
ATOM   1765 N  N     . LEU A 1 290 ? 128.084 124.779 82.414  1.00 61.91 ? 290 LEU A N     1 
ATOM   1766 C  CA    . LEU A 1 290 ? 126.755 124.510 82.954  1.00 61.91 ? 290 LEU A CA    1 
ATOM   1767 C  C     . LEU A 1 290 ? 125.698 124.505 81.860  1.00 61.91 ? 290 LEU A C     1 
ATOM   1768 O  O     . LEU A 1 290 ? 124.844 123.611 81.816  1.00 61.91 ? 290 LEU A O     1 
ATOM   1769 C  CB    . LEU A 1 290 ? 126.396 125.545 84.019  1.00 61.91 ? 290 LEU A CB    1 
ATOM   1770 C  CG    . LEU A 1 290 ? 126.592 125.189 85.492  1.00 61.91 ? 290 LEU A CG    1 
ATOM   1771 C  CD1   . LEU A 1 290 ? 128.030 124.829 85.777  1.00 61.91 ? 290 LEU A CD1   1 
ATOM   1772 C  CD2   . LEU A 1 290 ? 126.138 126.349 86.366  1.00 61.91 ? 290 LEU A CD2   1 
ATOM   1773 N  N     . LEU A 1 291 ? 125.741 125.491 80.965  1.00 62.16 ? 291 LEU A N     1 
ATOM   1774 C  CA    . LEU A 1 291 ? 124.671 125.658 79.989  1.00 62.16 ? 291 LEU A CA    1 
ATOM   1775 C  C     . LEU A 1 291 ? 124.653 124.551 78.944  1.00 62.16 ? 291 LEU A C     1 
ATOM   1776 O  O     . LEU A 1 291 ? 123.610 124.324 78.322  1.00 62.16 ? 291 LEU A O     1 
ATOM   1777 C  CB    . LEU A 1 291 ? 124.787 127.022 79.307  1.00 62.16 ? 291 LEU A CB    1 
ATOM   1778 C  CG    . LEU A 1 291 ? 124.195 128.240 80.028  1.00 62.16 ? 291 LEU A CG    1 
ATOM   1779 C  CD1   . LEU A 1 291 ? 122.687 128.095 80.168  1.00 62.16 ? 291 LEU A CD1   1 
ATOM   1780 C  CD2   . LEU A 1 291 ? 124.840 128.497 81.382  1.00 62.16 ? 291 LEU A CD2   1 
ATOM   1781 N  N     . THR A 1 292 ? 125.770 123.858 78.737  1.00 62.29 ? 292 THR A N     1 
ATOM   1782 C  CA    . THR A 1 292 ? 125.850 122.781 77.761  1.00 62.29 ? 292 THR A CA    1 
ATOM   1783 C  C     . THR A 1 292 ? 125.684 121.404 78.389  1.00 62.29 ? 292 THR A C     1 
ATOM   1784 O  O     . THR A 1 292 ? 125.817 120.396 77.689  1.00 62.29 ? 292 THR A O     1 
ATOM   1785 C  CB    . THR A 1 292 ? 127.178 122.849 77.004  1.00 62.29 ? 292 THR A CB    1 
ATOM   1786 O  OG1   . THR A 1 292 ? 128.257 122.566 77.903  1.00 62.29 ? 292 THR A OG1   1 
ATOM   1787 C  CG2   . THR A 1 292 ? 127.378 124.233 76.404  1.00 62.29 ? 292 THR A CG2   1 
ATOM   1788 N  N     . ALA A 1 293 ? 125.400 121.336 79.686  1.00 60.78 ? 293 ALA A N     1 
ATOM   1789 C  CA    . ALA A 1 293 ? 125.220 120.065 80.369  1.00 60.78 ? 293 ALA A CA    1 
ATOM   1790 C  C     . ALA A 1 293 ? 123.769 119.601 80.268  1.00 60.78 ? 293 ALA A C     1 
ATOM   1791 O  O     . ALA A 1 293 ? 122.847 120.389 80.051  1.00 60.78 ? 293 ALA A O     1 
ATOM   1792 C  CB    . ALA A 1 293 ? 125.646 120.180 81.831  1.00 60.78 ? 293 ALA A CB    1 
ATOM   1793 N  N     . LYS A 1 294 ? 123.600 118.282 80.491  1.00 59.37 ? 294 LYS A N     1 
ATOM   1794 C  CA    . LYS A 1 294 ? 122.344 117.465 80.384  1.00 59.37 ? 294 LYS A CA    1 
ATOM   1795 C  C     . LYS A 1 294 ? 121.499 117.398 81.673  1.00 59.37 ? 294 LYS A C     1 
ATOM   1796 O  O     . LYS A 1 294 ? 122.023 116.952 82.693  1.00 59.37 ? 294 LYS A O     1 
ATOM   1797 C  CB    . LYS A 1 294 ? 122.747 116.035 80.021  1.00 59.37 ? 294 LYS A CB    1 
ATOM   1798 C  CG    . LYS A 1 294 ? 122.833 115.745 78.530  1.00 59.37 ? 294 LYS A CG    1 
ATOM   1799 C  CD    . LYS A 1 294 ? 122.306 114.368 78.174  1.00 59.37 ? 294 LYS A CD    1 
ATOM   1800 C  CE    . LYS A 1 294 ? 122.738 113.879 76.811  1.00 59.37 ? 294 LYS A CE    1 
ATOM   1801 N  NZ    . LYS A 1 294 ? 124.210 113.901 76.667  1.00 59.37 ? 294 LYS A NZ    1 
ATOM   1802 N  N     . TRP A 1 295 ? 120.185 117.630 81.582  1.00 54.28 ? 295 TRP A N     1 
ATOM   1803 C  CA    . TRP A 1 295 ? 119.322 117.720 82.753  1.00 54.28 ? 295 TRP A CA    1 
ATOM   1804 C  C     . TRP A 1 295 ? 119.613 116.628 83.778  1.00 54.28 ? 295 TRP A C     1 
ATOM   1805 O  O     . TRP A 1 295 ? 119.316 116.813 84.961  1.00 54.28 ? 295 TRP A O     1 
ATOM   1806 C  CB    . TRP A 1 295 ? 117.857 117.656 82.304  1.00 54.28 ? 295 TRP A CB    1 
ATOM   1807 C  CG    . TRP A 1 295 ? 116.819 117.845 83.382  1.00 54.28 ? 295 TRP A CG    1 
ATOM   1808 C  CD1   . TRP A 1 295 ? 117.013 118.323 84.645  1.00 54.28 ? 295 TRP A CD1   1 
ATOM   1809 C  CD2   . TRP A 1 295 ? 115.422 117.542 83.281  1.00 54.28 ? 295 TRP A CD2   1 
ATOM   1810 N  NE1   . TRP A 1 295 ? 115.827 118.340 85.334  1.00 54.28 ? 295 TRP A NE1   1 
ATOM   1811 C  CE2   . TRP A 1 295 ? 114.834 117.866 84.519  1.00 54.28 ? 295 TRP A CE2   1 
ATOM   1812 C  CE3   . TRP A 1 295 ? 114.612 117.031 82.263  1.00 54.28 ? 295 TRP A CE3   1 
ATOM   1813 C  CZ2   . TRP A 1 295 ? 113.475 117.696 84.765  1.00 54.28 ? 295 TRP A CZ2   1 
ATOM   1814 C  CZ3   . TRP A 1 295 ? 113.265 116.862 82.511  1.00 54.28 ? 295 TRP A CZ3   1 
ATOM   1815 C  CH2   . TRP A 1 295 ? 112.709 117.193 83.751  1.00 54.28 ? 295 TRP A CH2   1 
ATOM   1816 N  N     . ARG A 1 296 ? 120.220 115.517 83.371  1.00 56.86 ? 296 ARG A N     1 
ATOM   1817 C  CA    . ARG A 1 296 ? 120.576 114.442 84.288  1.00 56.86 ? 296 ARG A CA    1 
ATOM   1818 C  C     . ARG A 1 296 ? 121.886 114.705 85.014  1.00 56.86 ? 296 ARG A C     1 
ATOM   1819 O  O     . ARG A 1 296 ? 122.023 114.355 86.189  1.00 56.86 ? 296 ARG A O     1 
ATOM   1820 C  CB    . ARG A 1 296 ? 120.660 113.108 83.532  1.00 56.86 ? 296 ARG A CB    1 
ATOM   1821 C  CG    . ARG A 1 296 ? 120.825 111.894 84.431  1.00 56.86 ? 296 ARG A CG    1 
ATOM   1822 C  CD    . ARG A 1 296 ? 119.582 111.653 85.267  1.00 56.86 ? 296 ARG A CD    1 
ATOM   1823 N  NE    . ARG A 1 296 ? 118.374 111.603 84.453  1.00 56.86 ? 296 ARG A NE    1 
ATOM   1824 C  CZ    . ARG A 1 296 ? 117.919 110.510 83.856  1.00 56.86 ? 296 ARG A CZ    1 
ATOM   1825 N  NH1   . ARG A 1 296 ? 118.544 109.350 83.969  1.00 56.86 ? 296 ARG A NH1   1 
ATOM   1826 N  NH2   . ARG A 1 296 ? 116.805 110.581 83.132  1.00 56.86 ? 296 ARG A NH2   1 
ATOM   1827 N  N     . ALA A 1 297 ? 122.864 115.311 84.337  1.00 53.85 ? 297 ALA A N     1 
ATOM   1828 C  CA    . ALA A 1 297 ? 124.139 115.603 84.983  1.00 53.85 ? 297 ALA A CA    1 
ATOM   1829 C  C     . ALA A 1 297 ? 124.040 116.798 85.922  1.00 53.85 ? 297 ALA A C     1 
ATOM   1830 O  O     . ALA A 1 297 ? 124.710 116.823 86.960  1.00 53.85 ? 297 ALA A O     1 
ATOM   1831 C  CB    . ALA A 1 297 ? 125.220 115.847 83.930  1.00 53.85 ? 297 ALA A CB    1 
ATOM   1832 N  N     . LEU A 1 298 ? 123.227 117.795 85.572  1.00 46.77 ? 298 LEU A N     1 
ATOM   1833 C  CA    . LEU A 1 298 ? 123.126 118.999 86.391  1.00 46.77 ? 298 LEU A CA    1 
ATOM   1834 C  C     . LEU A 1 298 ? 122.579 118.677 87.776  1.00 46.77 ? 298 LEU A C     1 
ATOM   1835 O  O     . LEU A 1 298 ? 123.132 119.110 88.797  1.00 46.77 ? 298 LEU A O     1 
ATOM   1836 C  CB    . LEU A 1 298 ? 122.245 120.025 85.679  1.00 46.77 ? 298 LEU A CB    1 
ATOM   1837 C  CG    . LEU A 1 298 ? 122.118 121.431 86.255  1.00 46.77 ? 298 LEU A CG    1 
ATOM   1838 C  CD1   . LEU A 1 298 ? 123.256 122.298 85.764  1.00 46.77 ? 298 LEU A CD1   1 
ATOM   1839 C  CD2   . LEU A 1 298 ? 120.788 122.033 85.849  1.00 46.77 ? 298 LEU A CD2   1 
ATOM   1840 N  N     . LYS A 1 299 ? 121.498 117.896 87.831  1.00 44.64 ? 299 LYS A N     1 
ATOM   1841 C  CA    . LYS A 1 299 ? 120.924 117.527 89.120  1.00 44.64 ? 299 LYS A CA    1 
ATOM   1842 C  C     . LYS A 1 299 ? 121.869 116.629 89.904  1.00 44.64 ? 299 LYS A C     1 
ATOM   1843 O  O     . LYS A 1 299 ? 121.936 116.713 91.134  1.00 44.64 ? 299 LYS A O     1 
ATOM   1844 C  CB    . LYS A 1 299 ? 119.572 116.846 88.921  1.00 44.64 ? 299 LYS A CB    1 
ATOM   1845 C  CG    . LYS A 1 299 ? 118.900 116.440 90.215  1.00 44.64 ? 299 LYS A CG    1 
ATOM   1846 C  CD    . LYS A 1 299 ? 118.221 117.627 90.869  1.00 44.64 ? 299 LYS A CD    1 
ATOM   1847 C  CE    . LYS A 1 299 ? 117.347 117.191 92.028  1.00 44.64 ? 299 LYS A CE    1 
ATOM   1848 N  NZ    . LYS A 1 299 ? 118.152 116.612 93.136  1.00 44.64 ? 299 LYS A NZ    1 
ATOM   1849 N  N     . GLY A 1 300 ? 122.607 115.761 89.212  1.00 45.89 ? 300 GLY A N     1 
ATOM   1850 C  CA    . GLY A 1 300 ? 123.600 114.951 89.897  1.00 45.89 ? 300 GLY A CA    1 
ATOM   1851 C  C     . GLY A 1 300 ? 124.686 115.791 90.542  1.00 45.89 ? 300 GLY A C     1 
ATOM   1852 O  O     . GLY A 1 300 ? 125.087 115.539 91.682  1.00 45.89 ? 300 GLY A O     1 
ATOM   1853 N  N     . ALA A 1 301 ? 125.169 116.807 89.826  1.00 45.92 ? 301 ALA A N     1 
ATOM   1854 C  CA    . ALA A 1 301 ? 126.161 117.710 90.399  1.00 45.92 ? 301 ALA A CA    1 
ATOM   1855 C  C     . ALA A 1 301 ? 125.592 118.466 91.592  1.00 45.92 ? 301 ALA A C     1 
ATOM   1856 O  O     . ALA A 1 301 ? 126.283 118.651 92.600  1.00 45.92 ? 301 ALA A O     1 
ATOM   1857 C  CB    . ALA A 1 301 ? 126.664 118.684 89.336  1.00 45.92 ? 301 ALA A CB    1 
ATOM   1858 N  N     . TYR A 1 302 ? 124.338 118.916 91.496  1.00 44.54 ? 302 TYR A N     1 
ATOM   1859 C  CA    . TYR A 1 302 ? 123.729 119.628 92.617  1.00 44.54 ? 302 TYR A CA    1 
ATOM   1860 C  C     . TYR A 1 302 ? 123.601 118.727 93.841  1.00 44.54 ? 302 TYR A C     1 
ATOM   1861 O  O     . TYR A 1 302 ? 123.883 119.146 94.973  1.00 44.54 ? 302 TYR A O     1 
ATOM   1862 C  CB    . TYR A 1 302 ? 122.363 120.178 92.216  1.00 44.54 ? 302 TYR A CB    1 
ATOM   1863 C  CG    . TYR A 1 302 ? 121.618 120.810 93.366  1.00 44.54 ? 302 TYR A CG    1 
ATOM   1864 C  CD1   . TYR A 1 302 ? 120.688 120.088 94.099  1.00 44.54 ? 302 TYR A CD1   1 
ATOM   1865 C  CD2   . TYR A 1 302 ? 121.857 122.124 93.731  1.00 44.54 ? 302 TYR A CD2   1 
ATOM   1866 C  CE1   . TYR A 1 302 ? 120.010 120.662 95.153  1.00 44.54 ? 302 TYR A CE1   1 
ATOM   1867 C  CE2   . TYR A 1 302 ? 121.185 122.705 94.786  1.00 44.54 ? 302 TYR A CE2   1 
ATOM   1868 C  CZ    . TYR A 1 302 ? 120.263 121.970 95.493  1.00 44.54 ? 302 TYR A CZ    1 
ATOM   1869 O  OH    . TYR A 1 302 ? 119.593 122.551 96.541  1.00 44.54 ? 302 TYR A OH    1 
ATOM   1870 N  N     . ASP A 1 303 ? 123.162 117.484 93.631  1.00 43.97 ? 303 ASP A N     1 
ATOM   1871 C  CA    . ASP A 1 303 ? 123.041 116.544 94.738  1.00 43.97 ? 303 ASP A CA    1 
ATOM   1872 C  C     . ASP A 1 303 ? 124.396 116.258 95.360  1.00 43.97 ? 303 ASP A C     1 
ATOM   1873 O  O     . ASP A 1 303 ? 124.520 116.189 96.586  1.00 43.97 ? 303 ASP A O     1 
ATOM   1874 C  CB    . ASP A 1 303 ? 122.387 115.249 94.264  1.00 43.97 ? 303 ASP A CB    1 
ATOM   1875 C  CG    . ASP A 1 303 ? 120.884 115.367 94.152  1.00 43.97 ? 303 ASP A CG    1 
ATOM   1876 O  OD1   . ASP A 1 303 ? 120.292 116.168 94.905  1.00 43.97 ? 303 ASP A OD1   1 
ATOM   1877 O  OD2   . ASP A 1 303 ? 120.292 114.653 93.316  1.00 43.97 ? 303 ASP A OD2   1 
ATOM   1878 N  N     . THR A 1 304 ? 125.428 116.097 94.530  1.00 44.59 ? 304 THR A N     1 
ATOM   1879 C  CA    . THR A 1 304 ? 126.765 115.867 95.064  1.00 44.59 ? 304 THR A CA    1 
ATOM   1880 C  C     . THR A 1 304 ? 127.251 117.062 95.872  1.00 44.59 ? 304 THR A C     1 
ATOM   1881 O  O     . THR A 1 304 ? 127.868 116.893 96.928  1.00 44.59 ? 304 THR A O     1 
ATOM   1882 C  CB    . THR A 1 304 ? 127.738 115.550 93.932  1.00 44.59 ? 304 THR A CB    1 
ATOM   1883 O  OG1   . THR A 1 304 ? 127.156 114.570 93.063  1.00 44.59 ? 304 THR A OG1   1 
ATOM   1884 C  CG2   . THR A 1 304 ? 129.042 115.010 94.492  1.00 44.59 ? 304 THR A CG2   1 
ATOM   1885 N  N     . TRP A 1 305 ? 126.979 118.280 95.398  1.00 43.62 ? 305 TRP A N     1 
ATOM   1886 C  CA    . TRP A 1 305 ? 127.410 119.465 96.134  1.00 43.62 ? 305 TRP A CA    1 
ATOM   1887 C  C     . TRP A 1 305 ? 126.723 119.555 97.491  1.00 43.62 ? 305 TRP A C     1 
ATOM   1888 O  O     . TRP A 1 305 ? 127.380 119.799 98.511  1.00 43.62 ? 305 TRP A O     1 
ATOM   1889 C  CB    . TRP A 1 305 ? 127.143 120.727 95.313  1.00 43.62 ? 305 TRP A CB    1 
ATOM   1890 C  CG    . TRP A 1 305 ? 127.315 122.002 96.091  1.00 43.62 ? 305 TRP A CG    1 
ATOM   1891 C  CD1   . TRP A 1 305 ? 128.491 122.612 96.416  1.00 43.62 ? 305 TRP A CD1   1 
ATOM   1892 C  CD2   . TRP A 1 305 ? 126.275 122.820 96.641  1.00 43.62 ? 305 TRP A CD2   1 
ATOM   1893 N  NE1   . TRP A 1 305 ? 128.249 123.757 97.132  1.00 43.62 ? 305 TRP A NE1   1 
ATOM   1894 C  CE2   . TRP A 1 305 ? 126.896 123.907 97.285  1.00 43.62 ? 305 TRP A CE2   1 
ATOM   1895 C  CE3   . TRP A 1 305 ? 124.880 122.738 96.651  1.00 43.62 ? 305 TRP A CE3   1 
ATOM   1896 C  CZ2   . TRP A 1 305 ? 126.171 124.901 97.932  1.00 43.62 ? 305 TRP A CZ2   1 
ATOM   1897 C  CZ3   . TRP A 1 305 ? 124.165 123.725 97.294  1.00 43.62 ? 305 TRP A CZ3   1 
ATOM   1898 C  CH2   . TRP A 1 305 ? 124.810 124.792 97.925  1.00 43.62 ? 305 TRP A CH2   1 
ATOM   1899 N  N     . LYS A 1 306 ? 125.402 119.355 97.527  1.00 43.17 ? 306 LYS A N     1 
ATOM   1900 C  CA    . LYS A 1 306 ? 124.693 119.408 98.805  1.00 43.17 ? 306 LYS A CA    1 
ATOM   1901 C  C     . LYS A 1 306 ? 125.159 118.303 99.744  1.00 43.17 ? 306 LYS A C     1 
ATOM   1902 O  O     . LYS A 1 306 ? 125.325 118.524 100.953 1.00 43.17 ? 306 LYS A O     1 
ATOM   1903 C  CB    . LYS A 1 306 ? 123.185 119.313 98.582  1.00 43.17 ? 306 LYS A CB    1 
ATOM   1904 C  CG    . LYS A 1 306 ? 122.384 119.419 99.868  1.00 43.17 ? 306 LYS A CG    1 
ATOM   1905 C  CD    . LYS A 1 306 ? 121.075 120.153 99.657  1.00 43.17 ? 306 LYS A CD    1 
ATOM   1906 C  CE    . LYS A 1 306 ? 120.380 119.686 98.395  1.00 43.17 ? 306 LYS A CE    1 
ATOM   1907 N  NZ    . LYS A 1 306 ? 119.872 118.294 98.513  1.00 43.17 ? 306 LYS A NZ    1 
ATOM   1908 N  N     . LEU A 1 307 ? 125.375 117.103 99.204  1.00 43.03 ? 307 LEU A N     1 
ATOM   1909 C  CA    . LEU A 1 307 ? 125.853 115.999 100.021 1.00 43.03 ? 307 LEU A CA    1 
ATOM   1910 C  C     . LEU A 1 307 ? 127.233 116.293 100.588 1.00 43.03 ? 307 LEU A C     1 
ATOM   1911 O  O     . LEU A 1 307 ? 127.518 115.963 101.743 1.00 43.03 ? 307 LEU A O     1 
ATOM   1912 C  CB    . LEU A 1 307 ? 125.872 114.718 99.193  1.00 43.03 ? 307 LEU A CB    1 
ATOM   1913 C  CG    . LEU A 1 307 ? 126.299 113.466 99.943  1.00 43.03 ? 307 LEU A CG    1 
ATOM   1914 C  CD1   . LEU A 1 307 ? 125.302 113.230 101.041 1.00 43.03 ? 307 LEU A CD1   1 
ATOM   1915 C  CD2   . LEU A 1 307 ? 126.346 112.285 99.000  1.00 43.03 ? 307 LEU A CD2   1 
ATOM   1916 N  N     . LYS A 1 308 ? 128.107 116.913 99.794  1.00 42.97 ? 308 LYS A N     1 
ATOM   1917 C  CA    . LYS A 1 308 ? 129.437 117.249 100.290 1.00 42.97 ? 308 LYS A CA    1 
ATOM   1918 C  C     . LYS A 1 308 ? 129.359 118.331 101.360 1.00 42.97 ? 308 LYS A C     1 
ATOM   1919 O  O     . LYS A 1 308 ? 130.130 118.315 102.327 1.00 42.97 ? 308 LYS A O     1 
ATOM   1920 C  CB    . LYS A 1 308 ? 130.337 117.678 99.130  1.00 42.97 ? 308 LYS A CB    1 
ATOM   1921 C  CG    . LYS A 1 308 ? 131.776 118.005 99.517  1.00 42.97 ? 308 LYS A CG    1 
ATOM   1922 C  CD    . LYS A 1 308 ? 132.001 119.486 99.775  1.00 42.97 ? 308 LYS A CD    1 
ATOM   1923 C  CE    . LYS A 1 308 ? 131.939 120.288 98.489  1.00 42.97 ? 308 LYS A CE    1 
ATOM   1924 N  NZ    . LYS A 1 308 ? 132.175 121.736 98.736  1.00 42.97 ? 308 LYS A NZ    1 
ATOM   1925 N  N     . LYS A 1 309 ? 128.433 119.279 101.206 1.00 42.60 ? 309 LYS A N     1 
ATOM   1926 C  CA    . LYS A 1 309 ? 128.243 120.288 102.244 1.00 42.60 ? 309 LYS A CA    1 
ATOM   1927 C  C     . LYS A 1 309 ? 127.820 119.646 103.559 1.00 42.60 ? 309 LYS A C     1 
ATOM   1928 O  O     . LYS A 1 309 ? 128.364 119.967 104.623 1.00 42.60 ? 309 LYS A O     1 
ATOM   1929 C  CB    . LYS A 1 309 ? 127.214 121.324 101.795 1.00 42.60 ? 309 LYS A CB    1 
ATOM   1930 C  CG    . LYS A 1 309 ? 127.658 122.164 100.616 1.00 42.60 ? 309 LYS A CG    1 
ATOM   1931 C  CD    . LYS A 1 309 ? 128.886 122.990 100.956 1.00 42.60 ? 309 LYS A CD    1 
ATOM   1932 C  CE    . LYS A 1 309 ? 128.541 124.135 101.889 1.00 42.60 ? 309 LYS A CE    1 
ATOM   1933 N  NZ    . LYS A 1 309 ? 129.722 124.998 102.153 1.00 42.60 ? 309 LYS A NZ    1 
ATOM   1934 N  N     . ARG A 1 310 ? 126.859 118.719 103.508 1.00 42.72 ? 310 ARG A N     1 
ATOM   1935 C  CA    . ARG A 1 310 ? 126.466 118.035 104.739 1.00 42.72 ? 310 ARG A CA    1 
ATOM   1936 C  C     . ARG A 1 310 ? 127.610 117.198 105.291 1.00 42.72 ? 310 ARG A C     1 
ATOM   1937 O  O     . ARG A 1 310 ? 127.810 117.136 106.508 1.00 42.72 ? 310 ARG A O     1 
ATOM   1938 C  CB    . ARG A 1 310 ? 125.233 117.157 104.529 1.00 42.72 ? 310 ARG A CB    1 
ATOM   1939 C  CG    . ARG A 1 310 ? 123.940 117.923 104.328 1.00 42.72 ? 310 ARG A CG    1 
ATOM   1940 C  CD    . ARG A 1 310 ? 122.737 117.009 104.518 1.00 42.72 ? 310 ARG A CD    1 
ATOM   1941 N  NE    . ARG A 1 310 ? 122.618 115.982 103.492 1.00 42.72 ? 310 ARG A NE    1 
ATOM   1942 C  CZ    . ARG A 1 310 ? 122.750 114.684 103.722 1.00 42.72 ? 310 ARG A CZ    1 
ATOM   1943 N  NH1   . ARG A 1 310 ? 123.058 114.224 104.923 1.00 42.72 ? 310 ARG A NH1   1 
ATOM   1944 N  NH2   . ARG A 1 310 ? 122.570 113.826 102.723 1.00 42.72 ? 310 ARG A NH2   1 
ATOM   1945 N  N     . LEU A 1 311 ? 128.374 116.551 104.413 1.00 42.05 ? 311 LEU A N     1 
ATOM   1946 C  CA    . LEU A 1 311 ? 129.489 115.725 104.859 1.00 42.05 ? 311 LEU A CA    1 
ATOM   1947 C  C     . LEU A 1 311 ? 130.534 116.555 105.592 1.00 42.05 ? 311 LEU A C     1 
ATOM   1948 O  O     . LEU A 1 311 ? 131.125 116.094 106.575 1.00 42.05 ? 311 LEU A O     1 
ATOM   1949 C  CB    . LEU A 1 311 ? 130.109 115.007 103.661 1.00 42.05 ? 311 LEU A CB    1 
ATOM   1950 C  CG    . LEU A 1 311 ? 131.271 114.048 103.916 1.00 42.05 ? 311 LEU A CG    1 
ATOM   1951 C  CD1   . LEU A 1 311 ? 130.842 112.884 104.787 1.00 42.05 ? 311 LEU A CD1   1 
ATOM   1952 C  CD2   . LEU A 1 311 ? 131.830 113.551 102.599 1.00 42.05 ? 311 LEU A CD2   1 
ATOM   1953 N  N     . GLU A 1 312 ? 130.783 117.776 105.125 1.00 43.87 ? 312 GLU A N     1 
ATOM   1954 C  CA    . GLU A 1 312 ? 131.739 118.644 105.798 1.00 43.87 ? 312 GLU A CA    1 
ATOM   1955 C  C     . GLU A 1 312 ? 131.135 119.374 106.993 1.00 43.87 ? 312 GLU A C     1 
ATOM   1956 O  O     . GLU A 1 312 ? 131.886 119.905 107.817 1.00 43.87 ? 312 GLU A O     1 
ATOM   1957 C  CB    . GLU A 1 312 ? 132.324 119.647 104.800 1.00 43.87 ? 312 GLU A CB    1 
ATOM   1958 C  CG    . GLU A 1 312 ? 133.599 120.327 105.269 1.00 43.87 ? 312 GLU A CG    1 
ATOM   1959 C  CD    . GLU A 1 312 ? 134.305 121.074 104.155 1.00 43.87 ? 312 GLU A CD    1 
ATOM   1960 O  OE1   . GLU A 1 312 ? 133.802 121.053 103.012 1.00 43.87 ? 312 GLU A OE1   1 
ATOM   1961 O  OE2   . GLU A 1 312 ? 135.363 121.680 104.422 1.00 43.87 ? 312 GLU A OE2   1 
ATOM   1962 N  N     . LYS A 1 313 ? 129.807 119.403 107.118 1.00 43.70 ? 313 LYS A N     1 
ATOM   1963 C  CA    . LYS A 1 313 ? 129.170 119.986 108.295 1.00 43.70 ? 313 LYS A CA    1 
ATOM   1964 C  C     . LYS A 1 313 ? 129.012 118.995 109.443 1.00 43.70 ? 313 LYS A C     1 
ATOM   1965 O  O     . LYS A 1 313 ? 129.061 119.399 110.611 1.00 43.70 ? 313 LYS A O     1 
ATOM   1966 C  CB    . LYS A 1 313 ? 127.797 120.553 107.923 1.00 43.70 ? 313 LYS A CB    1 
ATOM   1967 C  CG    . LYS A 1 313 ? 127.053 121.207 109.075 1.00 43.70 ? 313 LYS A CG    1 
ATOM   1968 C  CD    . LYS A 1 313 ? 125.958 122.126 108.576 1.00 43.70 ? 313 LYS A CD    1 
ATOM   1969 C  CE    . LYS A 1 313 ? 126.540 123.411 108.020 1.00 43.70 ? 313 LYS A CE    1 
ATOM   1970 N  NZ    . LYS A 1 313 ? 127.170 124.229 109.090 1.00 43.70 ? 313 LYS A NZ    1 
ATOM   1971 N  N     . ARG A 1 314 ? 128.833 117.712 109.141 1.00 40.52 ? 314 ARG A N     1 
ATOM   1972 C  CA    . ARG A 1 314 ? 128.600 116.709 110.172 1.00 40.52 ? 314 ARG A CA    1 
ATOM   1973 C  C     . ARG A 1 314 ? 129.824 116.535 111.061 1.00 40.52 ? 314 ARG A C     1 
ATOM   1974 O  O     . ARG A 1 314 ? 130.963 116.546 110.588 1.00 40.52 ? 314 ARG A O     1 
ATOM   1975 C  CB    . ARG A 1 314 ? 128.242 115.371 109.533 1.00 40.52 ? 314 ARG A CB    1 
ATOM   1976 C  CG    . ARG A 1 314 ? 126.768 115.034 109.558 1.00 40.52 ? 314 ARG A CG    1 
ATOM   1977 C  CD    . ARG A 1 314 ? 126.478 113.903 108.598 1.00 40.52 ? 314 ARG A CD    1 
ATOM   1978 N  NE    . ARG A 1 314 ? 127.285 112.725 108.890 1.00 40.52 ? 314 ARG A NE    1 
ATOM   1979 C  CZ    . ARG A 1 314 ? 126.815 111.616 109.440 1.00 40.52 ? 314 ARG A CZ    1 
ATOM   1980 N  NH1   . ARG A 1 314 ? 125.538 111.491 109.760 1.00 40.52 ? 314 ARG A NH1   1 
ATOM   1981 N  NH2   . ARG A 1 314 ? 127.645 110.603 109.671 1.00 40.52 ? 314 ARG A NH2   1 
ATOM   1982 N  N     . LYS A 1 315 ? 129.580 116.361 112.357 1.00 41.73 ? 315 LYS A N     1 
ATOM   1983 C  CA    . LYS A 1 315 ? 130.665 116.111 113.290 1.00 41.73 ? 315 LYS A CA    1 
ATOM   1984 C  C     . LYS A 1 315 ? 131.238 114.716 113.067 1.00 41.73 ? 315 LYS A C     1 
ATOM   1985 O  O     . LYS A 1 315 ? 130.593 113.830 112.502 1.00 41.73 ? 315 LYS A O     1 
ATOM   1986 C  CB    . LYS A 1 315 ? 130.191 116.258 114.734 1.00 41.73 ? 315 LYS A CB    1 
ATOM   1987 C  CG    . LYS A 1 315 ? 129.146 115.243 115.152 1.00 41.73 ? 315 LYS A CG    1 
ATOM   1988 C  CD    . LYS A 1 315 ? 128.756 115.423 116.606 1.00 41.73 ? 315 LYS A CD    1 
ATOM   1989 C  CE    . LYS A 1 315 ? 127.694 114.425 117.008 1.00 41.73 ? 315 LYS A CE    1 
ATOM   1990 N  NZ    . LYS A 1 315 ? 126.418 114.690 116.295 1.00 41.73 ? 315 LYS A NZ    1 
ATOM   1991 N  N     . ALA A 1 316 ? 132.476 114.530 113.523 1.00 42.45 ? 316 ALA A N     1 
ATOM   1992 C  CA    . ALA A 1 316 ? 133.206 113.313 113.191 1.00 42.45 ? 316 ALA A CA    1 
ATOM   1993 C  C     . ALA A 1 316 ? 132.615 112.089 113.881 1.00 42.45 ? 316 ALA A C     1 
ATOM   1994 O  O     . ALA A 1 316 ? 132.414 111.051 113.242 1.00 42.45 ? 316 ALA A O     1 
ATOM   1995 C  CB    . ALA A 1 316 ? 134.680 113.474 113.556 1.00 42.45 ? 316 ALA A CB    1 
ATOM   1996 N  N     . PHE A 1 317 ? 132.321 112.191 115.173 1.00 42.57 ? 317 PHE A N     1 
ATOM   1997 C  CA    . PHE A 1 317 ? 132.025 111.036 116.006 1.00 42.57 ? 317 PHE A CA    1 
ATOM   1998 C  C     . PHE A 1 317 ? 130.752 111.273 116.803 1.00 42.57 ? 317 PHE A C     1 
ATOM   1999 O  O     . PHE A 1 317 ? 130.377 112.426 117.047 1.00 42.57 ? 317 PHE A O     1 
ATOM   2000 C  CB    . PHE A 1 317 ? 133.192 110.749 116.960 1.00 42.57 ? 317 PHE A CB    1 
ATOM   2001 C  CG    . PHE A 1 317 ? 134.404 110.197 116.280 1.00 42.57 ? 317 PHE A CG    1 
ATOM   2002 C  CD1   . PHE A 1 317 ? 135.657 110.360 116.837 1.00 42.57 ? 317 PHE A CD1   1 
ATOM   2003 C  CD2   . PHE A 1 317 ? 134.289 109.489 115.103 1.00 42.57 ? 317 PHE A CD2   1 
ATOM   2004 C  CE1   . PHE A 1 317 ? 136.773 109.853 116.221 1.00 42.57 ? 317 PHE A CE1   1 
ATOM   2005 C  CE2   . PHE A 1 317 ? 135.405 108.974 114.481 1.00 42.57 ? 317 PHE A CE2   1 
ATOM   2006 C  CZ    . PHE A 1 317 ? 136.649 109.155 115.043 1.00 42.57 ? 317 PHE A CZ    1 
ATOM   2007 N  N     . PRO A 1 318 ? 130.065 110.207 117.215 1.00 40.12 ? 318 PRO A N     1 
ATOM   2008 C  CA    . PRO A 1 318 ? 128.835 110.380 117.993 1.00 40.12 ? 318 PRO A CA    1 
ATOM   2009 C  C     . PRO A 1 318 ? 129.125 110.898 119.392 1.00 40.12 ? 318 PRO A C     1 
ATOM   2010 O  O     . PRO A 1 318 ? 130.204 110.702 119.952 1.00 40.12 ? 318 PRO A O     1 
ATOM   2011 C  CB    . PRO A 1 318 ? 128.233 108.970 118.042 1.00 40.12 ? 318 PRO A CB    1 
ATOM   2012 C  CG    . PRO A 1 318 ? 129.058 108.135 117.121 1.00 40.12 ? 318 PRO A CG    1 
ATOM   2013 C  CD    . PRO A 1 318 ? 130.387 108.786 117.019 1.00 40.12 ? 318 PRO A CD    1 
ATOM   2014 N  N     . TYR A 1 319 ? 128.129 111.572 119.958 1.00 46.19 ? 319 TYR A N     1 
ATOM   2015 C  CA    . TYR A 1 319 ? 128.238 112.075 121.319 1.00 46.19 ? 319 TYR A CA    1 
ATOM   2016 C  C     . TYR A 1 319 ? 128.268 110.927 122.320 1.00 46.19 ? 319 TYR A C     1 
ATOM   2017 O  O     . TYR A 1 319 ? 127.566 109.924 122.172 1.00 46.19 ? 319 TYR A O     1 
ATOM   2018 C  CB    . TYR A 1 319 ? 127.065 112.995 121.645 1.00 46.19 ? 319 TYR A CB    1 
ATOM   2019 C  CG    . TYR A 1 319 ? 127.267 114.431 121.244 1.00 46.19 ? 319 TYR A CG    1 
ATOM   2020 C  CD1   . TYR A 1 319 ? 128.483 115.055 121.436 1.00 46.19 ? 319 TYR A CD1   1 
ATOM   2021 C  CD2   . TYR A 1 319 ? 126.233 115.167 120.691 1.00 46.19 ? 319 TYR A CD2   1 
ATOM   2022 C  CE1   . TYR A 1 319 ? 128.673 116.368 121.077 1.00 46.19 ? 319 TYR A CE1   1 
ATOM   2023 C  CE2   . TYR A 1 319 ? 126.412 116.481 120.331 1.00 46.19 ? 319 TYR A CE2   1 
ATOM   2024 C  CZ    . TYR A 1 319 ? 127.636 117.076 120.526 1.00 46.19 ? 319 TYR A CZ    1 
ATOM   2025 O  OH    . TYR A 1 319 ? 127.824 118.388 120.167 1.00 46.19 ? 319 TYR A OH    1 
ATOM   2026 N  N     . MET A 1 320 ? 129.089 111.084 123.353 1.00 46.62 ? 320 MET A N     1 
ATOM   2027 C  CA    . MET A 1 320 ? 129.043 110.155 124.466 1.00 46.62 ? 320 MET A CA    1 
ATOM   2028 C  C     . MET A 1 320 ? 127.767 110.394 125.273 1.00 46.62 ? 320 MET A C     1 
ATOM   2029 O  O     . MET A 1 320 ? 127.364 111.540 125.484 1.00 46.62 ? 320 MET A O     1 
ATOM   2030 C  CB    . MET A 1 320 ? 130.287 110.309 125.336 1.00 46.62 ? 320 MET A CB    1 
ATOM   2031 C  CG    . MET A 1 320 ? 130.413 111.647 126.030 1.00 46.62 ? 320 MET A CG    1 
ATOM   2032 S  SD    . MET A 1 320 ? 131.897 111.762 127.042 1.00 46.62 ? 320 MET A SD    1 
ATOM   2033 C  CE    . MET A 1 320 ? 131.480 110.686 128.394 1.00 46.62 ? 320 MET A CE    1 
ATOM   2034 N  N     . PRO A 1 321 ? 127.097 109.329 125.708 1.00 43.60 ? 321 PRO A N     1 
ATOM   2035 C  CA    . PRO A 1 321 ? 125.734 109.479 126.234 1.00 43.60 ? 321 PRO A CA    1 
ATOM   2036 C  C     . PRO A 1 321 ? 125.680 110.328 127.495 1.00 43.60 ? 321 PRO A C     1 
ATOM   2037 O  O     . PRO A 1 321 ? 126.605 110.331 128.309 1.00 43.60 ? 321 PRO A O     1 
ATOM   2038 C  CB    . PRO A 1 321 ? 125.313 108.033 126.513 1.00 43.60 ? 321 PRO A CB    1 
ATOM   2039 C  CG    . PRO A 1 321 ? 126.597 107.341 126.791 1.00 43.60 ? 321 PRO A CG    1 
ATOM   2040 C  CD    . PRO A 1 321 ? 127.554 107.933 125.795 1.00 43.60 ? 321 PRO A CD    1 
ATOM   2041 N  N     . ASN A 1 322 ? 124.578 111.061 127.640 1.00 44.71 ? 322 ASN A N     1 
ATOM   2042 C  CA    . ASN A 1 322 ? 124.354 111.854 128.841 1.00 44.71 ? 322 ASN A CA    1 
ATOM   2043 C  C     . ASN A 1 322 ? 124.085 110.936 130.026 1.00 44.71 ? 322 ASN A C     1 
ATOM   2044 O  O     . ASN A 1 322 ? 123.370 109.939 129.912 1.00 44.71 ? 322 ASN A O     1 
ATOM   2045 C  CB    . ASN A 1 322 ? 123.183 112.812 128.630 1.00 44.71 ? 322 ASN A CB    1 
ATOM   2046 C  CG    . ASN A 1 322 ? 123.141 113.915 129.663 1.00 44.71 ? 322 ASN A CG    1 
ATOM   2047 O  OD1   . ASN A 1 322 ? 123.480 113.710 130.826 1.00 44.71 ? 322 ASN A OD1   1 
ATOM   2048 N  ND2   . ASN A 1 322 ? 122.730 115.102 129.238 1.00 44.71 ? 322 ASN A ND2   1 
ATOM   2049 N  N     . TRP A 1 323 ? 124.659 111.283 131.175 1.00 42.56 ? 323 TRP A N     1 
ATOM   2050 C  CA    . TRP A 1 323 ? 124.723 110.373 132.310 1.00 42.56 ? 323 TRP A CA    1 
ATOM   2051 C  C     . TRP A 1 323 ? 124.032 110.908 133.555 1.00 42.56 ? 323 TRP A C     1 
ATOM   2052 O  O     . TRP A 1 323 ? 123.780 110.139 134.487 1.00 42.56 ? 323 TRP A O     1 
ATOM   2053 C  CB    . TRP A 1 323 ? 126.185 110.041 132.589 1.00 42.56 ? 323 TRP A CB    1 
ATOM   2054 C  CG    . TRP A 1 323 ? 126.678 109.023 131.633 1.00 42.56 ? 323 TRP A CG    1 
ATOM   2055 C  CD1   . TRP A 1 323 ? 125.917 108.184 130.879 1.00 42.56 ? 323 TRP A CD1   1 
ATOM   2056 C  CD2   . TRP A 1 323 ? 128.031 108.802 131.234 1.00 42.56 ? 323 TRP A CD2   1 
ATOM   2057 N  NE1   . TRP A 1 323 ? 126.714 107.407 130.080 1.00 42.56 ? 323 TRP A NE1   1 
ATOM   2058 C  CE2   . TRP A 1 323 ? 128.018 107.772 130.274 1.00 42.56 ? 323 TRP A CE2   1 
ATOM   2059 C  CE3   . TRP A 1 323 ? 129.252 109.356 131.612 1.00 42.56 ? 323 TRP A CE3   1 
ATOM   2060 C  CZ2   . TRP A 1 323 ? 129.178 107.286 129.689 1.00 42.56 ? 323 TRP A CZ2   1 
ATOM   2061 C  CZ3   . TRP A 1 323 ? 130.398 108.874 131.031 1.00 42.56 ? 323 TRP A CZ3   1 
ATOM   2062 C  CH2   . TRP A 1 323 ? 130.356 107.851 130.078 1.00 42.56 ? 323 TRP A CH2   1 
ATOM   2063 N  N     . ASP A 1 324 ? 123.709 112.196 133.596 1.00 43.24 ? 324 ASP A N     1 
ATOM   2064 C  CA    . ASP A 1 324 ? 122.900 112.719 134.688 1.00 43.24 ? 324 ASP A CA    1 
ATOM   2065 C  C     . ASP A 1 324 ? 121.450 112.271 134.593 1.00 43.24 ? 324 ASP A C     1 
ATOM   2066 O  O     . ASP A 1 324 ? 120.749 112.245 135.611 1.00 43.24 ? 324 ASP A O     1 
ATOM   2067 C  CB    . ASP A 1 324 ? 122.964 114.247 134.715 1.00 43.24 ? 324 ASP A CB    1 
ATOM   2068 C  CG    . ASP A 1 324 ? 124.296 114.766 135.216 1.00 43.24 ? 324 ASP A CG    1 
ATOM   2069 O  OD1   . ASP A 1 324 ? 124.682 115.890 134.829 1.00 43.24 ? 324 ASP A OD1   1 
ATOM   2070 O  OD2   . ASP A 1 324 ? 124.959 114.048 135.994 1.00 43.24 ? 324 ASP A OD2   1 
ATOM   2071 N  N     . ASN A 1 325 ? 120.988 111.918 133.396 1.00 39.84 ? 325 ASN A N     1 
ATOM   2072 C  CA    . ASN A 1 325 ? 119.614 111.476 133.217 1.00 39.84 ? 325 ASN A CA    1 
ATOM   2073 C  C     . ASN A 1 325 ? 119.410 110.085 133.802 1.00 39.84 ? 325 ASN A C     1 
ATOM   2074 O  O     . ASN A 1 325 ? 120.349 109.295 133.933 1.00 39.84 ? 325 ASN A O     1 
ATOM   2075 C  CB    . ASN A 1 325 ? 119.245 111.481 131.737 1.00 39.84 ? 325 ASN A CB    1 
ATOM   2076 C  CG    . ASN A 1 325 ? 119.334 112.858 131.127 1.00 39.84 ? 325 ASN A CG    1 
ATOM   2077 O  OD1   . ASN A 1 325 ? 119.753 113.810 131.781 1.00 39.84 ? 325 ASN A OD1   1 
ATOM   2078 N  ND2   . ASN A 1 325 ? 118.939 112.974 129.866 1.00 39.84 ? 325 ASN A ND2   1 
ATOM   2079 N  N     . ASP A 1 326 ? 118.162 109.789 134.152 1.00 37.51 ? 326 ASP A N     1 
ATOM   2080 C  CA    . ASP A 1 326 ? 117.804 108.520 134.764 1.00 37.51 ? 326 ASP A CA    1 
ATOM   2081 C  C     . ASP A 1 326 ? 117.479 107.481 133.697 1.00 37.51 ? 326 ASP A C     1 
ATOM   2082 O  O     . ASP A 1 326 ? 117.020 107.810 132.600 1.00 37.51 ? 326 ASP A O     1 
ATOM   2083 C  CB    . ASP A 1 326 ? 116.612 108.697 135.703 1.00 37.51 ? 326 ASP A CB    1 
ATOM   2084 C  CG    . ASP A 1 326 ? 117.030 109.055 137.112 1.00 37.51 ? 326 ASP A CG    1 
ATOM   2085 O  OD1   . ASP A 1 326 ? 118.050 108.518 137.588 1.00 37.51 ? 326 ASP A OD1   1 
ATOM   2086 O  OD2   . ASP A 1 326 ? 116.341 109.879 137.744 1.00 37.51 ? 326 ASP A OD2   1 
ATOM   2087 N  N     . TYR A 1 327 ? 117.718 106.218 134.033 1.00 32.23 ? 327 TYR A N     1 
ATOM   2088 C  CA    . TYR A 1 327 ? 117.483 105.106 133.126 1.00 32.23 ? 327 TYR A CA    1 
ATOM   2089 C  C     . TYR A 1 327 ? 116.415 104.183 133.703 1.00 32.23 ? 327 TYR A C     1 
ATOM   2090 O  O     . TYR A 1 327 ? 116.279 104.054 134.922 1.00 32.23 ? 327 TYR A O     1 
ATOM   2091 C  CB    . TYR A 1 327 ? 118.779 104.323 132.864 1.00 32.23 ? 327 TYR A CB    1 
ATOM   2092 C  CG    . TYR A 1 327 ? 118.838 103.694 131.494 1.00 32.23 ? 327 TYR A CG    1 
ATOM   2093 C  CD1   . TYR A 1 327 ? 118.845 104.477 130.352 1.00 32.23 ? 327 TYR A CD1   1 
ATOM   2094 C  CD2   . TYR A 1 327 ? 118.875 102.319 131.343 1.00 32.23 ? 327 TYR A CD2   1 
ATOM   2095 C  CE1   . TYR A 1 327 ? 118.890 103.907 129.101 1.00 32.23 ? 327 TYR A CE1   1 
ATOM   2096 C  CE2   . TYR A 1 327 ? 118.921 101.742 130.098 1.00 32.23 ? 327 TYR A CE2   1 
ATOM   2097 C  CZ    . TYR A 1 327 ? 118.929 102.540 128.980 1.00 32.23 ? 327 TYR A CZ    1 
ATOM   2098 O  OH    . TYR A 1 327 ? 118.976 101.964 127.733 1.00 32.23 ? 327 TYR A OH    1 
ATOM   2099 N  N     . GLN A 1 328 ? 115.649 103.552 132.814 1.00 29.82 ? 328 GLN A N     1 
ATOM   2100 C  CA    . GLN A 1 328 ? 114.617 102.619 133.245 1.00 29.82 ? 328 GLN A CA    1 
ATOM   2101 C  C     . GLN A 1 328 ? 115.246 101.391 133.885 1.00 29.82 ? 328 GLN A C     1 
ATOM   2102 O  O     . GLN A 1 328 ? 116.232 100.845 133.386 1.00 29.82 ? 328 GLN A O     1 
ATOM   2103 C  CB    . GLN A 1 328 ? 113.738 102.203 132.070 1.00 29.82 ? 328 GLN A CB    1 
ATOM   2104 C  CG    . GLN A 1 328 ? 114.499 101.772 130.837 1.00 29.82 ? 328 GLN A CG    1 
ATOM   2105 C  CD    . GLN A 1 328 ? 113.577 101.359 129.708 1.00 29.82 ? 328 GLN A CD    1 
ATOM   2106 O  OE1   . GLN A 1 328 ? 112.437 101.814 129.626 1.00 29.82 ? 328 GLN A OE1   1 
ATOM   2107 N  NE2   . GLN A 1 328 ? 114.067 100.491 128.831 1.00 29.82 ? 328 GLN A NE2   1 
ATOM   2108 N  N     . ILE A 1 329 ? 114.662 100.954 134.994 1.00 26.46 ? 329 ILE A N     1 
ATOM   2109 C  CA    . ILE A 1 329 ? 115.226 99.908  135.837 1.00 26.46 ? 329 ILE A CA    1 
ATOM   2110 C  C     . ILE A 1 329 ? 114.405 98.637  135.626 1.00 26.46 ? 329 ILE A C     1 
ATOM   2111 O  O     . ILE A 1 329 ? 113.208 98.613  135.945 1.00 26.46 ? 329 ILE A O     1 
ATOM   2112 C  CB    . ILE A 1 329 ? 115.250 100.338 137.309 1.00 26.46 ? 329 ILE A CB    1 
ATOM   2113 C  CG1   . ILE A 1 329 ? 116.396 101.322 137.539 1.00 26.46 ? 329 ILE A CG1   1 
ATOM   2114 C  CG2   . ILE A 1 329 ? 115.360 99.150  138.232 1.00 26.46 ? 329 ILE A CG2   1 
ATOM   2115 C  CD1   . ILE A 1 329 ? 116.586 101.709 138.973 1.00 26.46 ? 329 ILE A CD1   1 
ATOM   2116 N  N     . PRO A 1 330 ? 114.992 97.571  135.070 1.00 28.53 ? 330 PRO A N     1 
ATOM   2117 C  CA    . PRO A 1 330 ? 114.232 96.340  134.828 1.00 28.53 ? 330 PRO A CA    1 
ATOM   2118 C  C     . PRO A 1 330 ? 114.281 95.347  135.980 1.00 28.53 ? 330 PRO A C     1 
ATOM   2119 O  O     . PRO A 1 330 ? 115.362 94.978  136.448 1.00 28.53 ? 330 PRO A O     1 
ATOM   2120 C  CB    . PRO A 1 330 ? 114.912 95.766  133.583 1.00 28.53 ? 330 PRO A CB    1 
ATOM   2121 C  CG    . PRO A 1 330 ? 116.328 96.207  133.712 1.00 28.53 ? 330 PRO A CG    1 
ATOM   2122 C  CD    . PRO A 1 330 ? 116.338 97.506  134.479 1.00 28.53 ? 330 PRO A CD    1 
ATOM   2123 N  N     . VAL A 1 331 ? 113.115 94.891  136.428 1.00 29.53 ? 331 VAL A N     1 
ATOM   2124 C  CA    . VAL A 1 331 ? 113.015 93.846  137.440 1.00 29.53 ? 331 VAL A CA    1 
ATOM   2125 C  C     . VAL A 1 331 ? 111.922 92.873  137.018 1.00 29.53 ? 331 VAL A C     1 
ATOM   2126 O  O     . VAL A 1 331 ? 110.887 93.281  136.481 1.00 29.53 ? 331 VAL A O     1 
ATOM   2127 C  CB    . VAL A 1 331 ? 112.751 94.439  138.842 1.00 29.53 ? 331 VAL A CB    1 
ATOM   2128 C  CG1   . VAL A 1 331 ? 111.443 95.197  138.875 1.00 29.53 ? 331 VAL A CG1   1 
ATOM   2129 C  CG2   . VAL A 1 331 ? 112.769 93.345  139.900 1.00 29.53 ? 331 VAL A CG2   1 
ATOM   2130 N  N     . GLY A 1 332 ? 112.165 91.579  137.236 1.00 36.51 ? 332 GLY A N     1 
ATOM   2131 C  CA    . GLY A 1 332 ? 111.237 90.546  136.814 1.00 36.51 ? 332 GLY A CA    1 
ATOM   2132 C  C     . GLY A 1 332 ? 111.051 89.420  137.813 1.00 36.51 ? 332 GLY A C     1 
ATOM   2133 O  O     . GLY A 1 332 ? 111.003 89.662  139.021 1.00 36.51 ? 332 GLY A O     1 
ATOM   2134 N  N     . LEU A 1 333 ? 110.936 88.182  137.319 1.00 45.82 ? 333 LEU A N     1 
ATOM   2135 C  CA    . LEU A 1 333 ? 110.746 87.018  138.179 1.00 45.82 ? 333 LEU A CA    1 
ATOM   2136 C  C     . LEU A 1 333 ? 111.831 85.962  138.001 1.00 45.82 ? 333 LEU A C     1 
ATOM   2137 O  O     . LEU A 1 333 ? 111.728 84.885  138.599 1.00 45.82 ? 333 LEU A O     1 
ATOM   2138 C  CB    . LEU A 1 333 ? 109.386 86.355  137.925 1.00 45.82 ? 333 LEU A CB    1 
ATOM   2139 C  CG    . LEU A 1 333 ? 108.078 87.124  138.079 1.00 45.82 ? 333 LEU A CG    1 
ATOM   2140 C  CD1   . LEU A 1 333 ? 107.560 87.545  136.717 1.00 45.82 ? 333 LEU A CD1   1 
ATOM   2141 C  CD2   . LEU A 1 333 ? 107.051 86.284  138.809 1.00 45.82 ? 333 LEU A CD2   1 
ATOM   2142 N  N     . THR A 1 334 ? 112.864 86.233  137.210 1.00 52.27 ? 334 THR A N     1 
ATOM   2143 C  CA    . THR A 1 334 ? 113.833 85.220  136.806 1.00 52.27 ? 334 THR A CA    1 
ATOM   2144 C  C     . THR A 1 334 ? 115.112 85.294  137.633 1.00 52.27 ? 334 THR A C     1 
ATOM   2145 O  O     . THR A 1 334 ? 116.216 85.096  137.120 1.00 52.27 ? 334 THR A O     1 
ATOM   2146 C  CB    . THR A 1 334 ? 114.157 85.347  135.320 1.00 52.27 ? 334 THR A CB    1 
ATOM   2147 O  OG1   . THR A 1 334 ? 114.669 86.658  135.051 1.00 52.27 ? 334 THR A OG1   1 
ATOM   2148 C  CG2   . THR A 1 334 ? 112.909 85.113  134.482 1.00 52.27 ? 334 THR A CG2   1 
ATOM   2149 N  N     . GLY A 1 335 ? 114.977 85.575  138.926 1.00 49.26 ? 335 GLY A N     1 
ATOM   2150 C  CA    . GLY A 1 335 ? 116.110 85.670  139.812 1.00 49.26 ? 335 GLY A CA    1 
ATOM   2151 C  C     . GLY A 1 335 ? 116.686 87.061  139.966 1.00 49.26 ? 335 GLY A C     1 
ATOM   2152 O  O     . GLY A 1 335 ? 117.511 87.277  140.861 1.00 49.26 ? 335 GLY A O     1 
ATOM   2153 N  N     . LEU A 1 336 ? 116.285 88.008  139.113 1.00 46.10 ? 336 LEU A N     1 
ATOM   2154 C  CA    . LEU A 1 336 ? 116.702 89.393  139.300 1.00 46.10 ? 336 LEU A CA    1 
ATOM   2155 C  C     . LEU A 1 336 ? 116.153 89.950  140.606 1.00 46.10 ? 336 LEU A C     1 
ATOM   2156 O  O     . LEU A 1 336 ? 116.847 90.676  141.327 1.00 46.10 ? 336 LEU A O     1 
ATOM   2157 C  CB    . LEU A 1 336 ? 116.241 90.246  138.119 1.00 46.10 ? 336 LEU A CB    1 
ATOM   2158 C  CG    . LEU A 1 336 ? 116.898 89.955  136.769 1.00 46.10 ? 336 LEU A CG    1 
ATOM   2159 C  CD1   . LEU A 1 336 ? 116.410 90.935  135.716 1.00 46.10 ? 336 LEU A CD1   1 
ATOM   2160 C  CD2   . LEU A 1 336 ? 118.412 89.997  136.884 1.00 46.10 ? 336 LEU A CD2   1 
ATOM   2161 N  N     . GLY A 1 337 ? 114.912 89.615  140.925 1.00 46.25 ? 337 GLY A N     1 
ATOM   2162 C  CA    . GLY A 1 337 ? 114.285 90.065  142.142 1.00 46.25 ? 337 GLY A CA    1 
ATOM   2163 C  C     . GLY A 1 337 ? 112.973 89.344  142.338 1.00 46.25 ? 337 GLY A C     1 
ATOM   2164 O  O     . GLY A 1 337 ? 112.722 88.296  141.741 1.00 46.25 ? 337 GLY A O     1 
ATOM   2165 N  N     . VAL A 1 338 ? 112.134 89.918  143.192 1.00 51.36 ? 338 VAL A N     1 
ATOM   2166 C  CA    . VAL A 1 338 ? 110.819 89.367  143.485 1.00 51.36 ? 338 VAL A CA    1 
ATOM   2167 C  C     . VAL A 1 338 ? 109.792 90.471  143.307 1.00 51.36 ? 338 VAL A C     1 
ATOM   2168 O  O     . VAL A 1 338 ? 109.934 91.554  143.884 1.00 51.36 ? 338 VAL A O     1 
ATOM   2169 C  CB    . VAL A 1 338 ? 110.744 88.786  144.910 1.00 51.36 ? 338 VAL A CB    1 
ATOM   2170 C  CG1   . VAL A 1 338 ? 109.350 88.249  145.191 1.00 51.36 ? 338 VAL A CG1   1 
ATOM   2171 C  CG2   . VAL A 1 338 ? 111.789 87.697  145.102 1.00 51.36 ? 338 VAL A CG2   1 
ATOM   2172 N  N     . PHE A 1 339 ? 108.766 90.202  142.506 1.00 43.89 ? 339 PHE A N     1 
ATOM   2173 C  CA    . PHE A 1 339 ? 107.636 91.112  142.404 1.00 43.89 ? 339 PHE A CA    1 
ATOM   2174 C  C     . PHE A 1 339 ? 106.392 90.294  142.104 1.00 43.89 ? 339 PHE A C     1 
ATOM   2175 O  O     . PHE A 1 339 ? 106.436 89.330  141.337 1.00 43.89 ? 339 PHE A O     1 
ATOM   2176 C  CB    . PHE A 1 339 ? 107.861 92.197  141.339 1.00 43.89 ? 339 PHE A CB    1 
ATOM   2177 C  CG    . PHE A 1 339 ? 107.385 91.822  139.964 1.00 43.89 ? 339 PHE A CG    1 
ATOM   2178 C  CD1   . PHE A 1 339 ? 108.196 91.101  139.110 1.00 43.89 ? 339 PHE A CD1   1 
ATOM   2179 C  CD2   . PHE A 1 339 ? 106.133 92.208  139.519 1.00 43.89 ? 339 PHE A CD2   1 
ATOM   2180 C  CE1   . PHE A 1 339 ? 107.765 90.762  137.846 1.00 43.89 ? 339 PHE A CE1   1 
ATOM   2181 C  CE2   . PHE A 1 339 ? 105.697 91.867  138.258 1.00 43.89 ? 339 PHE A CE2   1 
ATOM   2182 C  CZ    . PHE A 1 339 ? 106.514 91.142  137.421 1.00 43.89 ? 339 PHE A CZ    1 
ATOM   2183 N  N     . THR A 1 340 ? 105.290 90.677  142.735 1.00 46.23 ? 340 THR A N     1 
ATOM   2184 C  CA    . THR A 1 340 ? 104.018 89.994  142.573 1.00 46.23 ? 340 THR A CA    1 
ATOM   2185 C  C     . THR A 1 340 ? 102.971 90.998  142.121 1.00 46.23 ? 340 THR A C     1 
ATOM   2186 O  O     . THR A 1 340 ? 102.838 92.076  142.706 1.00 46.23 ? 340 THR A O     1 
ATOM   2187 C  CB    . THR A 1 340 ? 103.568 89.321  143.874 1.00 46.23 ? 340 THR A CB    1 
ATOM   2188 O  OG1   . THR A 1 340 ? 103.385 90.314  144.889 1.00 46.23 ? 340 THR A OG1   1 
ATOM   2189 C  CG2   . THR A 1 340 ? 104.605 88.316  144.342 1.00 46.23 ? 340 THR A CG2   1 
ATOM   2190 N  N     . LEU A 1 341 ? 102.233 90.639  141.079 1.00 44.94 ? 341 LEU A N     1 
ATOM   2191 C  CA    . LEU A 1 341 ? 101.212 91.504  140.509 1.00 44.94 ? 341 LEU A CA    1 
ATOM   2192 C  C     . LEU A 1 341 ? 99.836  90.943  140.834 1.00 44.94 ? 341 LEU A C     1 
ATOM   2193 O  O     . LEU A 1 341 ? 99.510  89.819  140.443 1.00 44.94 ? 341 LEU A O     1 
ATOM   2194 C  CB    . LEU A 1 341 ? 101.390 91.624  138.995 1.00 44.94 ? 341 LEU A CB    1 
ATOM   2195 C  CG    . LEU A 1 341 ? 100.795 92.856  138.316 1.00 44.94 ? 341 LEU A CG    1 
ATOM   2196 C  CD1   . LEU A 1 341 ? 101.148 94.103  139.094 1.00 44.94 ? 341 LEU A CD1   1 
ATOM   2197 C  CD2   . LEU A 1 341 ? 101.284 92.964  136.886 1.00 44.94 ? 341 LEU A CD2   1 
ATOM   2198 N  N     . GLU A 1 342 ? 99.032  91.727  141.549 1.00 49.01 ? 342 GLU A N     1 
ATOM   2199 C  CA    . GLU A 1 342 ? 97.637  91.375  141.812 1.00 49.01 ? 342 GLU A CA    1 
ATOM   2200 C  C     . GLU A 1 342 ? 96.785  92.616  141.563 1.00 49.01 ? 342 GLU A C     1 
ATOM   2201 O  O     . GLU A 1 342 ? 97.064  93.695  142.092 1.00 49.01 ? 342 GLU A O     1 
ATOM   2202 C  CB    . GLU A 1 342 ? 97.447  90.809  143.218 1.00 49.01 ? 342 GLU A CB    1 
ATOM   2203 C  CG    . GLU A 1 342 ? 97.673  91.767  144.374 1.00 49.01 ? 342 GLU A CG    1 
ATOM   2204 C  CD    . GLU A 1 342 ? 99.133  91.845  144.782 1.00 49.01 ? 342 GLU A CD    1 
ATOM   2205 O  OE1   . GLU A 1 342 ? 99.998  91.405  143.996 1.00 49.01 ? 342 GLU A OE1   1 
ATOM   2206 O  OE2   . GLU A 1 342 ? 99.417  92.335  145.894 1.00 49.01 ? 342 GLU A OE2   1 
ATOM   2207 N  N     . VAL A 1 343 ? 95.760  92.456  140.735 1.00 47.45 ? 343 VAL A N     1 
ATOM   2208 C  CA    . VAL A 1 343 ? 94.947  93.570  140.268 1.00 47.45 ? 343 VAL A CA    1 
ATOM   2209 C  C     . VAL A 1 343 ? 93.631  93.565  141.028 1.00 47.45 ? 343 VAL A C     1 
ATOM   2210 O  O     . VAL A 1 343 ? 92.944  92.540  141.094 1.00 47.45 ? 343 VAL A O     1 
ATOM   2211 C  CB    . VAL A 1 343 ? 94.708  93.474  138.753 1.00 47.45 ? 343 VAL A CB    1 
ATOM   2212 C  CG1   . VAL A 1 343 ? 93.948  94.691  138.254 1.00 47.45 ? 343 VAL A CG1   1 
ATOM   2213 C  CG2   . VAL A 1 343 ? 96.024  93.310  138.016 1.00 47.45 ? 343 VAL A CG2   1 
ATOM   2214 N  N     . LYS A 1 344 ? 93.274  94.713  141.598 1.00 55.17 ? 344 LYS A N     1 
ATOM   2215 C  CA    . LYS A 1 344 ? 92.021  94.820  142.331 1.00 55.17 ? 344 LYS A CA    1 
ATOM   2216 C  C     . LYS A 1 344 ? 91.176  95.958  141.779 1.00 55.17 ? 344 LYS A C     1 
ATOM   2217 O  O     . LYS A 1 344 ? 91.525  96.558  140.757 1.00 55.17 ? 344 LYS A O     1 
ATOM   2218 C  CB    . LYS A 1 344 ? 92.290  95.002  143.825 1.00 55.17 ? 344 LYS A CB    1 
ATOM   2219 C  CG    . LYS A 1 344 ? 92.892  96.334  144.205 1.00 55.17 ? 344 LYS A CG    1 
ATOM   2220 C  CD    . LYS A 1 344 ? 93.481  96.272  145.604 1.00 55.17 ? 344 LYS A CD    1 
ATOM   2221 C  CE    . LYS A 1 344 ? 94.319  95.016  145.793 1.00 55.17 ? 344 LYS A CE    1 
ATOM   2222 N  NZ    . LYS A 1 344 ? 94.846  94.897  147.179 1.00 55.17 ? 344 LYS A NZ    1 
ATOM   2223 N  N     . ARG A 1 345 ? 90.065  96.261  142.453 1.00 62.79 ? 345 ARG A N     1 
ATOM   2224 C  CA    . ARG A 1 345 ? 89.036  97.109  141.858 1.00 62.79 ? 345 ARG A CA    1 
ATOM   2225 C  C     . ARG A 1 345 ? 89.551  98.512  141.561 1.00 62.79 ? 345 ARG A C     1 
ATOM   2226 O  O     . ARG A 1 345 ? 89.252  99.077  140.503 1.00 62.79 ? 345 ARG A O     1 
ATOM   2227 C  CB    . ARG A 1 345 ? 87.821  97.174  142.781 1.00 62.79 ? 345 ARG A CB    1 
ATOM   2228 C  CG    . ARG A 1 345 ? 86.564  97.689  142.109 1.00 62.79 ? 345 ARG A CG    1 
ATOM   2229 C  CD    . ARG A 1 345 ? 85.509  98.050  143.136 1.00 62.79 ? 345 ARG A CD    1 
ATOM   2230 N  NE    . ARG A 1 345 ? 85.477  99.485  143.390 1.00 62.79 ? 345 ARG A NE    1 
ATOM   2231 C  CZ    . ARG A 1 345 ? 84.574  100.315 142.888 1.00 62.79 ? 345 ARG A CZ    1 
ATOM   2232 N  NH1   . ARG A 1 345 ? 83.600  99.884  142.103 1.00 62.79 ? 345 ARG A NH1   1 
ATOM   2233 N  NH2   . ARG A 1 345 ? 84.649  101.610 143.181 1.00 62.79 ? 345 ARG A NH2   1 
ATOM   2234 N  N     . THR A 1 346 ? 90.325  99.091  142.473 1.00 57.43 ? 346 THR A N     1 
ATOM   2235 C  CA    . THR A 1 346 ? 90.682  100.499 142.374 1.00 57.43 ? 346 THR A CA    1 
ATOM   2236 C  C     . THR A 1 346 ? 92.115  100.751 141.926 1.00 57.43 ? 346 THR A C     1 
ATOM   2237 O  O     . THR A 1 346 ? 92.345  101.702 141.175 1.00 57.43 ? 346 THR A O     1 
ATOM   2238 C  CB    . THR A 1 346 ? 90.447  101.203 143.720 1.00 57.43 ? 346 THR A CB    1 
ATOM   2239 O  OG1   . THR A 1 346 ? 89.120  100.920 144.179 1.00 57.43 ? 346 THR A OG1   1 
ATOM   2240 C  CG2   . THR A 1 346 ? 90.599  102.708 143.573 1.00 57.43 ? 346 THR A CG2   1 
ATOM   2241 N  N     . GLU A 1 347 ? 93.078  99.933  142.340 1.00 51.33 ? 347 GLU A N     1 
ATOM   2242 C  CA    . GLU A 1 347 ? 94.470  100.173 141.999 1.00 51.33 ? 347 GLU A CA    1 
ATOM   2243 C  C     . GLU A 1 347 ? 95.172  98.863  141.669 1.00 51.33 ? 347 GLU A C     1 
ATOM   2244 O  O     . GLU A 1 347 ? 94.675  97.773  141.957 1.00 51.33 ? 347 GLU A O     1 
ATOM   2245 C  CB    . GLU A 1 347 ? 95.214  100.884 143.139 1.00 51.33 ? 347 GLU A CB    1 
ATOM   2246 C  CG    . GLU A 1 347 ? 95.512  100.014 144.356 1.00 51.33 ? 347 GLU A CG    1 
ATOM   2247 C  CD    . GLU A 1 347 ? 94.311  99.810  145.259 1.00 51.33 ? 347 GLU A CD    1 
ATOM   2248 O  OE1   . GLU A 1 347 ? 93.207  100.263 144.901 1.00 51.33 ? 347 GLU A OE1   1 
ATOM   2249 O  OE2   . GLU A 1 347 ? 94.476  99.205  146.339 1.00 51.33 ? 347 GLU A OE2   1 
ATOM   2250 N  N     . VAL A 1 348 ? 96.334  98.991  141.038 1.00 43.02 ? 348 VAL A N     1 
ATOM   2251 C  CA    . VAL A 1 348 ? 97.240  97.876  140.796 1.00 43.02 ? 348 VAL A CA    1 
ATOM   2252 C  C     . VAL A 1 348 ? 98.332  97.928  141.852 1.00 43.02 ? 348 VAL A C     1 
ATOM   2253 O  O     . VAL A 1 348 ? 98.785  99.014  142.236 1.00 43.02 ? 348 VAL A O     1 
ATOM   2254 C  CB    . VAL A 1 348 ? 97.833  97.938  139.376 1.00 43.02 ? 348 VAL A CB    1 
ATOM   2255 C  CG1   . VAL A 1 348 ? 98.704  96.730  139.103 1.00 43.02 ? 348 VAL A CG1   1 
ATOM   2256 C  CG2   . VAL A 1 348 ? 96.727  98.046  138.343 1.00 43.02 ? 348 VAL A CG2   1 
ATOM   2257 N  N     . VAL A 1 349 ? 98.749  96.763  142.339 1.00 44.68 ? 349 VAL A N     1 
ATOM   2258 C  CA    . VAL A 1 349 ? 99.723  96.675  143.419 1.00 44.68 ? 349 VAL A CA    1 
ATOM   2259 C  C     . VAL A 1 349 ? 100.889 95.809  142.965 1.00 44.68 ? 349 VAL A C     1 
ATOM   2260 O  O     . VAL A 1 349 ? 100.691 94.673  142.522 1.00 44.68 ? 349 VAL A O     1 
ATOM   2261 C  CB    . VAL A 1 349 ? 99.095  96.108  144.707 1.00 44.68 ? 349 VAL A CB    1 
ATOM   2262 C  CG1   . VAL A 1 349 ? 100.167 95.567  145.632 1.00 44.68 ? 349 VAL A CG1   1 
ATOM   2263 C  CG2   . VAL A 1 349 ? 98.276  97.175  145.407 1.00 44.68 ? 349 VAL A CG2   1 
ATOM   2264 N  N     . VAL A 1 350 ? 102.100 96.347  143.077 1.00 42.98 ? 350 VAL A N     1 
ATOM   2265 C  CA    . VAL A 1 350 ? 103.334 95.604  142.854 1.00 42.98 ? 350 VAL A CA    1 
ATOM   2266 C  C     . VAL A 1 350 ? 104.050 95.526  144.191 1.00 42.98 ? 350 VAL A C     1 
ATOM   2267 O  O     . VAL A 1 350 ? 104.315 96.558  144.817 1.00 42.98 ? 350 VAL A O     1 
ATOM   2268 C  CB    . VAL A 1 350 ? 104.223 96.271  141.794 1.00 42.98 ? 350 VAL A CB    1 
ATOM   2269 C  CG1   . VAL A 1 350 ? 105.407 95.381  141.456 1.00 42.98 ? 350 VAL A CG1   1 
ATOM   2270 C  CG2   . VAL A 1 350 ? 103.412 96.594  140.555 1.00 42.98 ? 350 VAL A CG2   1 
ATOM   2271 N  N     . ASP A 1 351 ? 104.357 94.313  144.631 1.00 50.56 ? 351 ASP A N     1 
ATOM   2272 C  CA    . ASP A 1 351 ? 104.833 94.070  145.990 1.00 50.56 ? 351 ASP A CA    1 
ATOM   2273 C  C     . ASP A 1 351 ? 106.234 93.466  145.945 1.00 50.56 ? 351 ASP A C     1 
ATOM   2274 O  O     . ASP A 1 351 ? 106.398 92.249  145.860 1.00 50.56 ? 351 ASP A O     1 
ATOM   2275 C  CB    . ASP A 1 351 ? 103.868 93.159  146.740 1.00 50.56 ? 351 ASP A CB    1 
ATOM   2276 C  CG    . ASP A 1 351 ? 104.225 93.012  148.203 1.00 50.56 ? 351 ASP A CG    1 
ATOM   2277 O  OD1   . ASP A 1 351 ? 104.344 91.862  148.674 1.00 50.56 ? 351 ASP A OD1   1 
ATOM   2278 O  OD2   . ASP A 1 351 ? 104.384 94.046  148.885 1.00 50.56 ? 351 ASP A OD2   1 
ATOM   2279 N  N     . LEU A 1 352 ? 107.244 94.326  146.013 1.00 52.99 ? 352 LEU A N     1 
ATOM   2280 C  CA    . LEU A 1 352 ? 108.597 93.849  146.253 1.00 52.99 ? 352 LEU A CA    1 
ATOM   2281 C  C     . LEU A 1 352 ? 108.724 93.384  147.698 1.00 52.99 ? 352 LEU A C     1 
ATOM   2282 O  O     . LEU A 1 352 ? 108.121 93.958  148.607 1.00 52.99 ? 352 LEU A O     1 
ATOM   2283 C  CB    . LEU A 1 352 ? 109.616 94.943  145.943 1.00 52.99 ? 352 LEU A CB    1 
ATOM   2284 C  CG    . LEU A 1 352 ? 109.468 95.616  144.575 1.00 52.99 ? 352 LEU A CG    1 
ATOM   2285 C  CD1   . LEU A 1 352 ? 108.751 96.944  144.695 1.00 52.99 ? 352 LEU A CD1   1 
ATOM   2286 C  CD2   . LEU A 1 352 ? 110.822 95.795  143.903 1.00 52.99 ? 352 LEU A CD2   1 
ATOM   2287 N  N     . LYS A 1 353 ? 109.515 92.330  147.905 1.00 58.08 ? 353 LYS A N     1 
ATOM   2288 C  CA    . LYS A 1 353 ? 109.509 91.637  149.190 1.00 58.08 ? 353 LYS A CA    1 
ATOM   2289 C  C     . LYS A 1 353 ? 110.034 92.519  150.320 1.00 58.08 ? 353 LYS A C     1 
ATOM   2290 O  O     . LYS A 1 353 ? 109.507 92.480  151.438 1.00 58.08 ? 353 LYS A O     1 
ATOM   2291 C  CB    . LYS A 1 353 ? 110.316 90.341  149.090 1.00 58.08 ? 353 LYS A CB    1 
ATOM   2292 C  CG    . LYS A 1 353 ? 111.773 90.520  148.694 1.00 58.08 ? 353 LYS A CG    1 
ATOM   2293 C  CD    . LYS A 1 353 ? 112.452 89.175  148.498 1.00 58.08 ? 353 LYS A CD    1 
ATOM   2294 C  CE    . LYS A 1 353 ? 113.927 89.338  148.171 1.00 58.08 ? 353 LYS A CE    1 
ATOM   2295 N  NZ    . LYS A 1 353 ? 114.532 90.492  148.888 1.00 58.08 ? 353 LYS A NZ    1 
ATOM   2296 N  N     . GLU A 1 354 ? 111.067 93.316  150.057 1.00 55.65 ? 354 GLU A N     1 
ATOM   2297 C  CA    . GLU A 1 354 ? 111.706 94.102  151.106 1.00 55.65 ? 354 GLU A CA    1 
ATOM   2298 C  C     . GLU A 1 354 ? 111.815 95.588  150.807 1.00 55.65 ? 354 GLU A C     1 
ATOM   2299 O  O     . GLU A 1 354 ? 112.006 96.368  151.748 1.00 55.65 ? 354 GLU A O     1 
ATOM   2300 C  CB    . GLU A 1 354 ? 113.112 93.557  151.400 1.00 55.65 ? 354 GLU A CB    1 
ATOM   2301 C  CG    . GLU A 1 354 ? 114.053 93.609  150.214 1.00 55.65 ? 354 GLU A CG    1 
ATOM   2302 C  CD    . GLU A 1 354 ? 115.397 92.982  150.512 1.00 55.65 ? 354 GLU A CD    1 
ATOM   2303 O  OE1   . GLU A 1 354 ? 115.581 92.481  151.640 1.00 55.65 ? 354 GLU A OE1   1 
ATOM   2304 O  OE2   . GLU A 1 354 ? 116.270 92.989  149.620 1.00 55.65 ? 354 GLU A OE2   1 
ATOM   2305 N  N     . HIS A 1 355 ? 111.702 96.010  149.554 1.00 49.58 ? 355 HIS A N     1 
ATOM   2306 C  CA    . HIS A 1 355 ? 111.818 97.414  149.194 1.00 49.58 ? 355 HIS A CA    1 
ATOM   2307 C  C     . HIS A 1 355 ? 110.477 98.132  149.162 1.00 49.58 ? 355 HIS A C     1 
ATOM   2308 O  O     . HIS A 1 355 ? 110.427 99.302  148.771 1.00 49.58 ? 355 HIS A O     1 
ATOM   2309 C  CB    . HIS A 1 355 ? 112.518 97.548  147.842 1.00 49.58 ? 355 HIS A CB    1 
ATOM   2310 C  CG    . HIS A 1 355 ? 113.858 96.885  147.794 1.00 49.58 ? 355 HIS A CG    1 
ATOM   2311 N  ND1   . HIS A 1 355 ? 114.164 95.889  146.893 1.00 49.58 ? 355 HIS A ND1   1 
ATOM   2312 C  CD2   . HIS A 1 355 ? 114.971 97.073  148.539 1.00 49.58 ? 355 HIS A CD2   1 
ATOM   2313 C  CE1   . HIS A 1 355 ? 115.409 95.493  147.084 1.00 49.58 ? 355 HIS A CE1   1 
ATOM   2314 N  NE2   . HIS A 1 355 ? 115.921 96.195  148.077 1.00 49.58 ? 355 HIS A NE2   1 
ATOM   2315 N  N     . GLY A 1 356 ? 109.401 97.470  149.553 1.00 49.63 ? 356 GLY A N     1 
ATOM   2316 C  CA    . GLY A 1 356 ? 108.101 98.096  149.665 1.00 49.63 ? 356 GLY A CA    1 
ATOM   2317 C  C     . GLY A 1 356 ? 107.184 97.714  148.518 1.00 49.63 ? 356 GLY A C     1 
ATOM   2318 O  O     . GLY A 1 356 ? 107.489 96.849  147.693 1.00 49.63 ? 356 GLY A O     1 
ATOM   2319 N  N     . LYS A 1 357 ? 106.034 98.385  148.480 1.00 46.27 ? 357 LYS A N     1 
ATOM   2320 C  CA    . LYS A 1 357 ? 105.029 98.155  147.456 1.00 46.27 ? 357 LYS A CA    1 
ATOM   2321 C  C     . LYS A 1 357 ? 104.626 99.478  146.821 1.00 46.27 ? 357 LYS A C     1 
ATOM   2322 O  O     . LYS A 1 357 ? 104.775 100.549 147.413 1.00 46.27 ? 357 LYS A O     1 
ATOM   2323 C  CB    . LYS A 1 357 ? 103.791 97.442  148.016 1.00 46.27 ? 357 LYS A CB    1 
ATOM   2324 C  CG    . LYS A 1 357 ? 103.003 98.244  149.026 1.00 46.27 ? 357 LYS A CG    1 
ATOM   2325 C  CD    . LYS A 1 357 ? 101.782 97.469  149.485 1.00 46.27 ? 357 LYS A CD    1 
ATOM   2326 C  CE    . LYS A 1 357 ? 102.173 96.309  150.384 1.00 46.27 ? 357 LYS A CE    1 
ATOM   2327 N  NZ    . LYS A 1 357 ? 102.760 96.775  151.670 1.00 46.27 ? 357 LYS A NZ    1 
ATOM   2328 N  N     . LEU A 1 358 ? 104.116 99.385  145.595 1.00 41.62 ? 358 LEU A N     1 
ATOM   2329 C  CA    . LEU A 1 358 ? 103.804 100.546 144.776 1.00 41.62 ? 358 LEU A CA    1 
ATOM   2330 C  C     . LEU A 1 358 ? 102.351 100.472 144.336 1.00 41.62 ? 358 LEU A C     1 
ATOM   2331 O  O     . LEU A 1 358 ? 101.899 99.425  143.864 1.00 41.62 ? 358 LEU A O     1 
ATOM   2332 C  CB    . LEU A 1 358 ? 104.726 100.615 143.555 1.00 41.62 ? 358 LEU A CB    1 
ATOM   2333 C  CG    . LEU A 1 358 ? 106.178 101.056 143.767 1.00 41.62 ? 358 LEU A CG    1 
ATOM   2334 C  CD1   . LEU A 1 358 ? 107.009 99.995  144.455 1.00 41.62 ? 358 LEU A CD1   1 
ATOM   2335 C  CD2   . LEU A 1 358 ? 106.808 101.393 142.446 1.00 41.62 ? 358 LEU A CD2   1 
ATOM   2336 N  N     . PHE A 1 359 ? 101.627 101.578 144.487 1.00 40.93 ? 359 PHE A N     1 
ATOM   2337 C  CA    . PHE A 1 359 ? 100.226 101.668 144.095 1.00 40.93 ? 359 PHE A CA    1 
ATOM   2338 C  C     . PHE A 1 359 ? 100.135 102.404 142.765 1.00 40.93 ? 359 PHE A C     1 
ATOM   2339 O  O     . PHE A 1 359 ? 100.538 103.567 142.668 1.00 40.93 ? 359 PHE A O     1 
ATOM   2340 C  CB    . PHE A 1 359 ? 99.404  102.394 145.159 1.00 40.93 ? 359 PHE A CB    1 
ATOM   2341 C  CG    . PHE A 1 359 ? 99.462  101.753 146.512 1.00 40.93 ? 359 PHE A CG    1 
ATOM   2342 C  CD1   . PHE A 1 359 ? 99.553  100.380 146.641 1.00 40.93 ? 359 PHE A CD1   1 
ATOM   2343 C  CD2   . PHE A 1 359 ? 99.441  102.526 147.657 1.00 40.93 ? 359 PHE A CD2   1 
ATOM   2344 C  CE1   . PHE A 1 359 ? 99.612  99.789  147.886 1.00 40.93 ? 359 PHE A CE1   1 
ATOM   2345 C  CE2   . PHE A 1 359 ? 99.502  101.940 148.904 1.00 40.93 ? 359 PHE A CE2   1 
ATOM   2346 C  CZ    . PHE A 1 359 ? 99.587  100.570 149.018 1.00 40.93 ? 359 PHE A CZ    1 
ATOM   2347 N  N     . CYS A 1 360 ? 99.593  101.736 141.752 1.00 35.59 ? 360 CYS A N     1 
ATOM   2348 C  CA    . CYS A 1 360 ? 99.510  102.281 140.406 1.00 35.59 ? 360 CYS A CA    1 
ATOM   2349 C  C     . CYS A 1 360 ? 98.054  102.346 139.972 1.00 35.59 ? 360 CYS A C     1 
ATOM   2350 O  O     . CYS A 1 360 ? 97.260  101.462 140.303 1.00 35.59 ? 360 CYS A O     1 
ATOM   2351 C  CB    . CYS A 1 360 ? 100.313 101.432 139.420 1.00 35.59 ? 360 CYS A CB    1 
ATOM   2352 S  SG    . CYS A 1 360 ? 101.930 100.914 140.032 1.00 35.59 ? 360 CYS A SG    1 
ATOM   2353 N  N     . SER A 1 361 ? 97.708  103.394 139.232 1.00 33.31 ? 361 SER A N     1 
ATOM   2354 C  CA    . SER A 1 361 ? 96.340  103.577 138.777 1.00 33.31 ? 361 SER A CA    1 
ATOM   2355 C  C     . SER A 1 361 ? 96.071  102.717 137.544 1.00 33.31 ? 361 SER A C     1 
ATOM   2356 O  O     . SER A 1 361 ? 96.967  102.075 136.992 1.00 33.31 ? 361 SER A O     1 
ATOM   2357 C  CB    . SER A 1 361 ? 96.071  105.052 138.493 1.00 33.31 ? 361 SER A CB    1 
ATOM   2358 O  OG    . SER A 1 361 ? 96.881  105.523 137.435 1.00 33.31 ? 361 SER A OG    1 
ATOM   2359 N  N     . HIS A 1 362 ? 94.817  102.703 137.105 1.00 35.54 ? 362 HIS A N     1 
ATOM   2360 C  CA    . HIS A 1 362 ? 94.401  101.933 135.942 1.00 35.54 ? 362 HIS A CA    1 
ATOM   2361 C  C     . HIS A 1 362 ? 94.515  102.770 134.677 1.00 35.54 ? 362 HIS A C     1 
ATOM   2362 O  O     . HIS A 1 362 ? 94.182  103.958 134.670 1.00 35.54 ? 362 HIS A O     1 
ATOM   2363 C  CB    . HIS A 1 362 ? 92.964  101.430 136.090 1.00 35.54 ? 362 HIS A CB    1 
ATOM   2364 C  CG    . HIS A 1 362 ? 92.813  100.307 137.065 1.00 35.54 ? 362 HIS A CG    1 
ATOM   2365 N  ND1   . HIS A 1 362 ? 92.538  100.508 138.399 1.00 35.54 ? 362 HIS A ND1   1 
ATOM   2366 C  CD2   . HIS A 1 362 ? 92.903  98.967  136.897 1.00 35.54 ? 362 HIS A CD2   1 
ATOM   2367 C  CE1   . HIS A 1 362 ? 92.463  99.340  139.010 1.00 35.54 ? 362 HIS A CE1   1 
ATOM   2368 N  NE2   . HIS A 1 362 ? 92.682  98.389  138.122 1.00 35.54 ? 362 HIS A NE2   1 
ATOM   2369 N  N     . SER A 1 363 ? 94.982  102.137 133.608 1.00 25.55 ? 363 SER A N     1 
ATOM   2370 C  CA    . SER A 1 363 ? 95.104  102.765 132.304 1.00 25.55 ? 363 SER A CA    1 
ATOM   2371 C  C     . SER A 1 363 ? 94.079  102.178 131.345 1.00 25.55 ? 363 SER A C     1 
ATOM   2372 O  O     . SER A 1 363 ? 93.663  101.026 131.475 1.00 25.55 ? 363 SER A O     1 
ATOM   2373 C  CB    . SER A 1 363 ? 96.516  102.587 131.739 1.00 25.55 ? 363 SER A CB    1 
ATOM   2374 O  OG    . SER A 1 363 ? 96.748  101.247 131.356 1.00 25.55 ? 363 SER A OG    1 
ATOM   2375 N  N     . HIS A 1 364 ? 93.663  102.998 130.382 1.00 27.13 ? 364 HIS A N     1 
ATOM   2376 C  CA    . HIS A 1 364 ? 92.748  102.533 129.352 1.00 27.13 ? 364 HIS A CA    1 
ATOM   2377 C  C     . HIS A 1 364 ? 93.422  101.613 128.346 1.00 27.13 ? 364 HIS A C     1 
ATOM   2378 O  O     . HIS A 1 364 ? 92.729  100.872 127.646 1.00 27.13 ? 364 HIS A O     1 
ATOM   2379 C  CB    . HIS A 1 364 ? 92.127  103.725 128.630 1.00 27.13 ? 364 HIS A CB    1 
ATOM   2380 C  CG    . HIS A 1 364 ? 90.948  104.310 129.339 1.00 27.13 ? 364 HIS A CG    1 
ATOM   2381 N  ND1   . HIS A 1 364 ? 91.069  105.080 130.474 1.00 27.13 ? 364 HIS A ND1   1 
ATOM   2382 C  CD2   . HIS A 1 364 ? 89.624  104.247 129.068 1.00 27.13 ? 364 HIS A CD2   1 
ATOM   2383 C  CE1   . HIS A 1 364 ? 89.871  105.462 130.875 1.00 27.13 ? 364 HIS A CE1   1 
ATOM   2384 N  NE2   . HIS A 1 364 ? 88.976  104.970 130.039 1.00 27.13 ? 364 HIS A NE2   1 
ATOM   2385 N  N     . TYR A 1 365 ? 94.749  101.653 128.251 1.00 27.01 ? 365 TYR A N     1 
ATOM   2386 C  CA    . TYR A 1 365 ? 95.464  100.703 127.409 1.00 27.01 ? 365 TYR A CA    1 
ATOM   2387 C  C     . TYR A 1 365 ? 95.264  99.280  127.912 1.00 27.01 ? 365 TYR A C     1 
ATOM   2388 O  O     . TYR A 1 365 ? 94.943  98.372  127.138 1.00 27.01 ? 365 TYR A O     1 
ATOM   2389 C  CB    . TYR A 1 365 ? 96.949  101.068 127.378 1.00 27.01 ? 365 TYR A CB    1 
ATOM   2390 C  CG    . TYR A 1 365 ? 97.780  100.365 126.328 1.00 27.01 ? 365 TYR A CG    1 
ATOM   2391 C  CD1   . TYR A 1 365 ? 97.917  100.890 125.056 1.00 27.01 ? 365 TYR A CD1   1 
ATOM   2392 C  CD2   . TYR A 1 365 ? 98.455  99.195  126.624 1.00 27.01 ? 365 TYR A CD2   1 
ATOM   2393 C  CE1   . TYR A 1 365 ? 98.684  100.260 124.103 1.00 27.01 ? 365 TYR A CE1   1 
ATOM   2394 C  CE2   . TYR A 1 365 ? 99.224  98.559  125.679 1.00 27.01 ? 365 TYR A CE2   1 
ATOM   2395 C  CZ    . TYR A 1 365 ? 99.335  99.096  124.420 1.00 27.01 ? 365 TYR A CZ    1 
ATOM   2396 O  OH    . TYR A 1 365 ? 100.103 98.457  123.477 1.00 27.01 ? 365 TYR A OH    1 
ATOM   2397 N  N     . PHE A 1 366 ? 95.446  99.069  129.212 1.00 26.84 ? 366 PHE A N     1 
ATOM   2398 C  CA    . PHE A 1 366 ? 95.216  97.769  129.844 1.00 26.84 ? 366 PHE A CA    1 
ATOM   2399 C  C     . PHE A 1 366 ? 93.821  97.718  130.463 1.00 26.84 ? 366 PHE A C     1 
ATOM   2400 O  O     . PHE A 1 366 ? 93.648  97.494  131.659 1.00 26.84 ? 366 PHE A O     1 
ATOM   2401 C  CB    . PHE A 1 366 ? 96.289  97.495  130.893 1.00 26.84 ? 366 PHE A CB    1 
ATOM   2402 C  CG    . PHE A 1 366 ? 97.685  97.457  130.346 1.00 26.84 ? 366 PHE A CG    1 
ATOM   2403 C  CD1   . PHE A 1 366 ? 98.431  98.612  130.239 1.00 26.84 ? 366 PHE A CD1   1 
ATOM   2404 C  CD2   . PHE A 1 366 ? 98.257  96.263  129.960 1.00 26.84 ? 366 PHE A CD2   1 
ATOM   2405 C  CE1   . PHE A 1 366 ? 99.711  98.578  129.748 1.00 26.84 ? 366 PHE A CE1   1 
ATOM   2406 C  CE2   . PHE A 1 366 ? 99.538  96.227  129.467 1.00 26.84 ? 366 PHE A CE2   1 
ATOM   2407 C  CZ    . PHE A 1 366 ? 100.264 97.386  129.360 1.00 26.84 ? 366 PHE A CZ    1 
ATOM   2408 N  N     . GLY A 1 367 ? 92.814  97.942  129.623 1.00 26.88 ? 367 GLY A N     1 
ATOM   2409 C  CA    . GLY A 1 367 ? 91.447  97.971  130.111 1.00 26.88 ? 367 GLY A CA    1 
ATOM   2410 C  C     . GLY A 1 367 ? 90.992  96.598  130.572 1.00 26.88 ? 367 GLY A C     1 
ATOM   2411 O  O     . GLY A 1 367 ? 91.320  95.577  129.968 1.00 26.88 ? 367 GLY A O     1 
ATOM   2412 N  N     . ASP A 1 368 ? 90.221  96.583  131.659 1.00 34.95 ? 368 ASP A N     1 
ATOM   2413 C  CA    . ASP A 1 368 ? 89.712  95.349  132.256 1.00 34.95 ? 368 ASP A CA    1 
ATOM   2414 C  C     . ASP A 1 368 ? 90.846  94.368  132.543 1.00 34.95 ? 368 ASP A C     1 
ATOM   2415 O  O     . ASP A 1 368 ? 90.753  93.170  132.271 1.00 34.95 ? 368 ASP A O     1 
ATOM   2416 C  CB    . ASP A 1 368 ? 88.649  94.707  131.365 1.00 34.95 ? 368 ASP A CB    1 
ATOM   2417 C  CG    . ASP A 1 368 ? 87.360  95.495  131.337 1.00 34.95 ? 368 ASP A CG    1 
ATOM   2418 O  OD1   . ASP A 1 368 ? 87.069  96.195  132.329 1.00 34.95 ? 368 ASP A OD1   1 
ATOM   2419 O  OD2   . ASP A 1 368 ? 86.633  95.411  130.326 1.00 34.95 ? 368 ASP A OD2   1 
ATOM   2420 N  N     . LEU A 1 369 ? 91.931  94.893  133.104 1.00 35.60 ? 369 LEU A N     1 
ATOM   2421 C  CA    . LEU A 1 369 ? 93.136  94.099  133.292 1.00 35.60 ? 369 LEU A CA    1 
ATOM   2422 C  C     . LEU A 1 369 ? 92.902  92.984  134.302 1.00 35.60 ? 369 LEU A C     1 
ATOM   2423 O  O     . LEU A 1 369 ? 92.305  93.202  135.360 1.00 35.60 ? 369 LEU A O     1 
ATOM   2424 C  CB    . LEU A 1 369 ? 94.284  94.990  133.754 1.00 35.60 ? 369 LEU A CB    1 
ATOM   2425 C  CG    . LEU A 1 369 ? 95.643  94.315  133.895 1.00 35.60 ? 369 LEU A CG    1 
ATOM   2426 C  CD1   . LEU A 1 369 ? 96.018  93.640  132.597 1.00 35.60 ? 369 LEU A CD1   1 
ATOM   2427 C  CD2   . LEU A 1 369 ? 96.695  95.324  134.298 1.00 35.60 ? 369 LEU A CD2   1 
ATOM   2428 N  N     . THR A 1 370 ? 93.368  91.783  133.965 1.00 40.03 ? 370 THR A N     1 
ATOM   2429 C  CA    . THR A 1 370 ? 93.396  90.657  134.887 1.00 40.03 ? 370 THR A CA    1 
ATOM   2430 C  C     . THR A 1 370 ? 94.732  89.948  134.741 1.00 40.03 ? 370 THR A C     1 
ATOM   2431 O  O     . THR A 1 370 ? 95.231  89.774  133.626 1.00 40.03 ? 370 THR A O     1 
ATOM   2432 C  CB    . THR A 1 370 ? 92.253  89.657  134.632 1.00 40.03 ? 370 THR A CB    1 
ATOM   2433 O  OG1   . THR A 1 370 ? 92.354  89.131  133.304 1.00 40.03 ? 370 THR A OG1   1 
ATOM   2434 C  CG2   . THR A 1 370 ? 90.894  90.319  134.816 1.00 40.03 ? 370 THR A CG2   1 
ATOM   2435 N  N     . ALA A 1 371 ? 95.310  89.544  135.864 1.00 46.78 ? 371 ALA A N     1 
ATOM   2436 C  CA    . ALA A 1 371 ? 96.575  88.832  135.868 1.00 46.78 ? 371 ALA A CA    1 
ATOM   2437 C  C     . ALA A 1 371 ? 96.476  87.631  136.794 1.00 46.78 ? 371 ALA A C     1 
ATOM   2438 O  O     . ALA A 1 371 ? 95.714  87.637  137.764 1.00 46.78 ? 371 ALA A O     1 
ATOM   2439 C  CB    . ALA A 1 371 ? 97.729  89.740  136.302 1.00 46.78 ? 371 ALA A CB    1 
ATOM   2440 N  N     . GLU A 1 372 ? 97.252  86.595  136.485 1.00 55.37 ? 372 GLU A N     1 
ATOM   2441 C  CA    . GLU A 1 372 ? 97.266  85.382  137.287 1.00 55.37 ? 372 GLU A CA    1 
ATOM   2442 C  C     . GLU A 1 372 ? 98.675  84.814  137.329 1.00 55.37 ? 372 GLU A C     1 
ATOM   2443 O  O     . GLU A 1 372 ? 99.391  84.826  136.324 1.00 55.37 ? 372 GLU A O     1 
ATOM   2444 C  CB    . GLU A 1 372 ? 96.282  84.337  136.742 1.00 55.37 ? 372 GLU A CB    1 
ATOM   2445 C  CG    . GLU A 1 372 ? 96.541  83.905  135.312 1.00 55.37 ? 372 GLU A CG    1 
ATOM   2446 C  CD    . GLU A 1 372 ? 95.459  82.990  134.783 1.00 55.37 ? 372 GLU A CD    1 
ATOM   2447 O  OE1   . GLU A 1 372 ? 94.490  82.728  135.525 1.00 55.37 ? 372 GLU A OE1   1 
ATOM   2448 O  OE2   . GLU A 1 372 ? 95.577  82.533  133.626 1.00 55.37 ? 372 GLU A OE2   1 
ATOM   2449 N  N     . LYS A 1 373 ? 99.063  84.318  138.499 1.00 59.28 ? 373 LYS A N     1 
ATOM   2450 C  CA    . LYS A 1 373 ? 100.412 83.812  138.694 1.00 59.28 ? 373 LYS A CA    1 
ATOM   2451 C  C     . LYS A 1 373 ? 100.638 82.536  137.895 1.00 59.28 ? 373 LYS A C     1 
ATOM   2452 O  O     . LYS A 1 373 ? 99.765  81.670  137.798 1.00 59.28 ? 373 LYS A O     1 
ATOM   2453 C  CB    . LYS A 1 373 ? 100.675 83.549  140.176 1.00 59.28 ? 373 LYS A CB    1 
ATOM   2454 C  CG    . LYS A 1 373 ? 102.102 83.120  140.498 1.00 59.28 ? 373 LYS A CG    1 
ATOM   2455 C  CD    . LYS A 1 373 ? 103.071 84.285  140.412 1.00 59.28 ? 373 LYS A CD    1 
ATOM   2456 C  CE    . LYS A 1 373 ? 104.494 83.851  140.727 1.00 59.28 ? 373 LYS A CE    1 
ATOM   2457 N  NZ    . LYS A 1 373 ? 105.135 83.146  139.585 1.00 59.28 ? 373 LYS A NZ    1 
ATOM   2458 N  N     . HIS A 1 374 ? 101.826 82.432  137.320 1.00 61.14 ? 374 HIS A N     1 
ATOM   2459 C  CA    . HIS A 1 374 ? 102.285 81.251  136.611 1.00 61.14 ? 374 HIS A CA    1 
ATOM   2460 C  C     . HIS A 1 374 ? 103.741 81.032  136.991 1.00 61.14 ? 374 HIS A C     1 
ATOM   2461 O  O     . HIS A 1 374 ? 104.405 81.961  137.460 1.00 61.14 ? 374 HIS A O     1 
ATOM   2462 C  CB    . HIS A 1 374 ? 102.113 81.416  135.095 1.00 61.14 ? 374 HIS A CB    1 
ATOM   2463 C  CG    . HIS A 1 374 ? 100.776 80.967  134.592 1.00 61.14 ? 374 HIS A CG    1 
ATOM   2464 N  ND1   . HIS A 1 374 ? 100.561 79.712  134.067 1.00 61.14 ? 374 HIS A ND1   1 
ATOM   2465 C  CD2   . HIS A 1 374 ? 99.583  81.604  134.544 1.00 61.14 ? 374 HIS A CD2   1 
ATOM   2466 C  CE1   . HIS A 1 374 ? 99.294  79.596  133.713 1.00 61.14 ? 374 HIS A CE1   1 
ATOM   2467 N  NE2   . HIS A 1 374 ? 98.678  80.730  133.992 1.00 61.14 ? 374 HIS A NE2   1 
ATOM   2468 N  N     . PRO A 1 375 ? 104.262 79.809  136.819 1.00 68.11 ? 375 PRO A N     1 
ATOM   2469 C  CA    . PRO A 1 375 ? 105.565 79.483  137.432 1.00 68.11 ? 375 PRO A CA    1 
ATOM   2470 C  C     . PRO A 1 375 ? 106.696 80.430  137.063 1.00 68.11 ? 375 PRO A C     1 
ATOM   2471 O  O     . PRO A 1 375 ? 107.523 80.754  137.923 1.00 68.11 ? 375 PRO A O     1 
ATOM   2472 C  CB    . PRO A 1 375 ? 105.839 78.057  136.927 1.00 68.11 ? 375 PRO A CB    1 
ATOM   2473 C  CG    . PRO A 1 375 ? 104.919 77.868  135.761 1.00 68.11 ? 375 PRO A CG    1 
ATOM   2474 C  CD    . PRO A 1 375 ? 103.700 78.648  136.111 1.00 68.11 ? 375 PRO A CD    1 
ATOM   2475 N  N     . SER A 1 376 ? 106.758 80.891  135.812 1.00 67.20 ? 376 SER A N     1 
ATOM   2476 C  CA    . SER A 1 376 ? 107.808 81.823  135.418 1.00 67.20 ? 376 SER A CA    1 
ATOM   2477 C  C     . SER A 1 376 ? 107.281 82.937  134.520 1.00 67.20 ? 376 SER A C     1 
ATOM   2478 O  O     . SER A 1 376 ? 108.042 83.478  133.709 1.00 67.20 ? 376 SER A O     1 
ATOM   2479 C  CB    . SER A 1 376 ? 108.952 81.091  134.711 1.00 67.20 ? 376 SER A CB    1 
ATOM   2480 O  OG    . SER A 1 376 ? 109.756 80.389  135.641 1.00 67.20 ? 376 SER A OG    1 
ATOM   2481 N  N     . ARG A 1 377 ? 106.009 83.294  134.645 1.00 55.64 ? 377 ARG A N     1 
ATOM   2482 C  CA    . ARG A 1 377 ? 105.384 84.274  133.769 1.00 55.64 ? 377 ARG A CA    1 
ATOM   2483 C  C     . ARG A 1 377 ? 104.094 84.747  134.427 1.00 55.64 ? 377 ARG A C     1 
ATOM   2484 O  O     . ARG A 1 377 ? 103.674 84.220  135.462 1.00 55.64 ? 377 ARG A O     1 
ATOM   2485 C  CB    . ARG A 1 377 ? 105.128 83.672  132.384 1.00 55.64 ? 377 ARG A CB    1 
ATOM   2486 C  CG    . ARG A 1 377 ? 104.020 82.633  132.385 1.00 55.64 ? 377 ARG A CG    1 
ATOM   2487 C  CD    . ARG A 1 377 ? 103.713 82.086  131.002 1.00 55.64 ? 377 ARG A CD    1 
ATOM   2488 N  NE    . ARG A 1 377 ? 102.322 81.659  130.900 1.00 55.64 ? 377 ARG A NE    1 
ATOM   2489 C  CZ    . ARG A 1 377 ? 101.447 82.149  130.033 1.00 55.64 ? 377 ARG A CZ    1 
ATOM   2490 N  NH1   . ARG A 1 377 ? 101.788 83.080  129.159 1.00 55.64 ? 377 ARG A NH1   1 
ATOM   2491 N  NH2   . ARG A 1 377 ? 100.199 81.690  130.041 1.00 55.64 ? 377 ARG A NH2   1 
ATOM   2492 N  N     . TYR A 1 378 ? 103.465 85.749  133.824 1.00 49.26 ? 378 TYR A N     1 
ATOM   2493 C  CA    . TYR A 1 378 ? 102.135 86.189  134.208 1.00 49.26 ? 378 TYR A CA    1 
ATOM   2494 C  C     . TYR A 1 378 ? 101.257 86.188  132.968 1.00 49.26 ? 378 TYR A C     1 
ATOM   2495 O  O     . TYR A 1 378 ? 101.740 86.340  131.844 1.00 49.26 ? 378 TYR A O     1 
ATOM   2496 C  CB    . TYR A 1 378 ? 102.151 87.582  134.848 1.00 49.26 ? 378 TYR A CB    1 
ATOM   2497 C  CG    . TYR A 1 378 ? 102.268 87.565  136.355 1.00 49.26 ? 378 TYR A CG    1 
ATOM   2498 C  CD1   . TYR A 1 378 ? 101.185 87.892  137.158 1.00 49.26 ? 378 TYR A CD1   1 
ATOM   2499 C  CD2   . TYR A 1 378 ? 103.459 87.214  136.976 1.00 49.26 ? 378 TYR A CD2   1 
ATOM   2500 C  CE1   . TYR A 1 378 ? 101.287 87.874  138.535 1.00 49.26 ? 378 TYR A CE1   1 
ATOM   2501 C  CE2   . TYR A 1 378 ? 103.569 87.194  138.352 1.00 49.26 ? 378 TYR A CE2   1 
ATOM   2502 C  CZ    . TYR A 1 378 ? 102.481 87.524  139.125 1.00 49.26 ? 378 TYR A CZ    1 
ATOM   2503 O  OH    . TYR A 1 378 ? 102.587 87.504  140.495 1.00 49.26 ? 378 TYR A OH    1 
ATOM   2504 N  N     . HIS A 1 379 ? 99.957  86.001  133.178 1.00 47.12 ? 379 HIS A N     1 
ATOM   2505 C  CA    . HIS A 1 379 ? 98.991  85.940  132.087 1.00 47.12 ? 379 HIS A CA    1 
ATOM   2506 C  C     . HIS A 1 379 ? 98.071  87.149  132.181 1.00 47.12 ? 379 HIS A C     1 
ATOM   2507 O  O     . HIS A 1 379 ? 97.181  87.192  133.036 1.00 47.12 ? 379 HIS A O     1 
ATOM   2508 C  CB    . HIS A 1 379 ? 98.192  84.641  132.132 1.00 47.12 ? 379 HIS A CB    1 
ATOM   2509 C  CG    . HIS A 1 379 ? 97.385  84.391  130.898 1.00 47.12 ? 379 HIS A CG    1 
ATOM   2510 N  ND1   . HIS A 1 379 ? 97.961  84.099  129.680 1.00 47.12 ? 379 HIS A ND1   1 
ATOM   2511 C  CD2   . HIS A 1 379 ? 96.048  84.392  130.692 1.00 47.12 ? 379 HIS A CD2   1 
ATOM   2512 C  CE1   . HIS A 1 379 ? 97.012  83.932  128.776 1.00 47.12 ? 379 HIS A CE1   1 
ATOM   2513 N  NE2   . HIS A 1 379 ? 95.842  84.104  129.364 1.00 47.12 ? 379 HIS A NE2   1 
ATOM   2514 N  N     . LEU A 1 380 ? 98.278  88.120  131.300 1.00 37.36 ? 380 LEU A N     1 
ATOM   2515 C  CA    . LEU A 1 380 ? 97.459  89.318  131.251 1.00 37.36 ? 380 LEU A CA    1 
ATOM   2516 C  C     . LEU A 1 380 ? 96.318  89.129  130.264 1.00 37.36 ? 380 LEU A C     1 
ATOM   2517 O  O     . LEU A 1 380 ? 96.466  88.491  129.220 1.00 37.36 ? 380 LEU A O     1 
ATOM   2518 C  CB    . LEU A 1 380 ? 98.285  90.544  130.856 1.00 37.36 ? 380 LEU A CB    1 
ATOM   2519 C  CG    . LEU A 1 380 ? 98.916  91.351  131.989 1.00 37.36 ? 380 LEU A CG    1 
ATOM   2520 C  CD1   . LEU A 1 380 ? 100.058 90.589  132.638 1.00 37.36 ? 380 LEU A CD1   1 
ATOM   2521 C  CD2   . LEU A 1 380 ? 99.389  92.695  131.466 1.00 37.36 ? 380 LEU A CD2   1 
ATOM   2522 N  N     . LYS A 1 381 ? 95.170  89.701  130.612 1.00 32.46 ? 381 LYS A N     1 
ATOM   2523 C  CA    . LYS A 1 381 ? 93.976  89.585  129.780 1.00 32.46 ? 381 LYS A CA    1 
ATOM   2524 C  C     . LYS A 1 381 ? 93.279  90.942  129.810 1.00 32.46 ? 381 LYS A C     1 
ATOM   2525 O  O     . LYS A 1 381 ? 92.446  91.198  130.683 1.00 32.46 ? 381 LYS A O     1 
ATOM   2526 C  CB    . LYS A 1 381 ? 93.073  88.466  130.279 1.00 32.46 ? 381 LYS A CB    1 
ATOM   2527 C  CG    . LYS A 1 381 ? 91.815  88.259  129.465 1.00 32.46 ? 381 LYS A CG    1 
ATOM   2528 C  CD    . LYS A 1 381 ? 91.035  87.058  129.959 1.00 32.46 ? 381 LYS A CD    1 
ATOM   2529 C  CE    . LYS A 1 381 ? 89.604  87.096  129.464 1.00 32.46 ? 381 LYS A CE    1 
ATOM   2530 N  NZ    . LYS A 1 381 ? 88.634  86.948  130.581 1.00 32.46 ? 381 LYS A NZ    1 
ATOM   2531 N  N     . PHE A 1 382 ? 93.625  91.797  128.854 1.00 28.04 ? 382 PHE A N     1 
ATOM   2532 C  CA    . PHE A 1 382 ? 93.148  93.167  128.811 1.00 28.04 ? 382 PHE A CA    1 
ATOM   2533 C  C     . PHE A 1 382 ? 92.640  93.479  127.415 1.00 28.04 ? 382 PHE A C     1 
ATOM   2534 O  O     . PHE A 1 382 ? 92.733  92.659  126.499 1.00 28.04 ? 382 PHE A O     1 
ATOM   2535 C  CB    . PHE A 1 382 ? 94.251  94.157  129.194 1.00 28.04 ? 382 PHE A CB    1 
ATOM   2536 C  CG    . PHE A 1 382 ? 95.448  94.115  128.285 1.00 28.04 ? 382 PHE A CG    1 
ATOM   2537 C  CD1   . PHE A 1 382 ? 96.455  93.190  128.484 1.00 28.04 ? 382 PHE A CD1   1 
ATOM   2538 C  CD2   . PHE A 1 382 ? 95.567  95.010  127.237 1.00 28.04 ? 382 PHE A CD2   1 
ATOM   2539 C  CE1   . PHE A 1 382 ? 97.548  93.154  127.651 1.00 28.04 ? 382 PHE A CE1   1 
ATOM   2540 C  CE2   . PHE A 1 382 ? 96.657  94.978  126.404 1.00 28.04 ? 382 PHE A CE2   1 
ATOM   2541 C  CZ    . PHE A 1 382 ? 97.648  94.049  126.610 1.00 28.04 ? 382 PHE A CZ    1 
ATOM   2542 N  N     . ARG A 1 383 ? 92.107  94.686  127.258 1.00 30.39 ? 383 ARG A N     1 
ATOM   2543 C  CA    . ARG A 1 383 ? 91.586  95.122  125.971 1.00 30.39 ? 383 ARG A CA    1 
ATOM   2544 C  C     . ARG A 1 383 ? 91.521  96.641  125.948 1.00 30.39 ? 383 ARG A C     1 
ATOM   2545 O  O     . ARG A 1 383 ? 91.174  97.265  126.954 1.00 30.39 ? 383 ARG A O     1 
ATOM   2546 C  CB    . ARG A 1 383 ? 90.214  94.497  125.708 1.00 30.39 ? 383 ARG A CB    1 
ATOM   2547 C  CG    . ARG A 1 383 ? 89.166  94.824  126.747 1.00 30.39 ? 383 ARG A CG    1 
ATOM   2548 C  CD    . ARG A 1 383 ? 87.918  94.003  126.519 1.00 30.39 ? 383 ARG A CD    1 
ATOM   2549 N  NE    . ARG A 1 383 ? 86.882  94.309  127.497 1.00 30.39 ? 383 ARG A NE    1 
ATOM   2550 C  CZ    . ARG A 1 383 ? 85.684  93.743  127.517 1.00 30.39 ? 383 ARG A CZ    1 
ATOM   2551 N  NH1   . ARG A 1 383 ? 85.340  92.826  126.628 1.00 30.39 ? 383 ARG A NH1   1 
ATOM   2552 N  NH2   . ARG A 1 383 ? 84.809  94.108  128.449 1.00 30.39 ? 383 ARG A NH2   1 
ATOM   2553 N  N     . HIS A 1 384 ? 91.876  97.227  124.810 1.00 24.34 ? 384 HIS A N     1 
ATOM   2554 C  CA    . HIS A 1 384 ? 91.948  98.674  124.696 1.00 24.34 ? 384 HIS A CA    1 
ATOM   2555 C  C     . HIS A 1 384 ? 90.568  99.297  124.831 1.00 24.34 ? 384 HIS A C     1 
ATOM   2556 O  O     . HIS A 1 384 ? 89.550  98.684  124.506 1.00 24.34 ? 384 HIS A O     1 
ATOM   2557 C  CB    . HIS A 1 384 ? 92.553  99.081  123.355 1.00 24.34 ? 384 HIS A CB    1 
ATOM   2558 C  CG    . HIS A 1 384 ? 93.975  98.654  123.171 1.00 24.34 ? 384 HIS A CG    1 
ATOM   2559 N  ND1   . HIS A 1 384 ? 94.726  98.105  124.185 1.00 24.34 ? 384 HIS A ND1   1 
ATOM   2560 C  CD2   . HIS A 1 384 ? 94.781  98.694  122.085 1.00 24.34 ? 384 HIS A CD2   1 
ATOM   2561 C  CE1   . HIS A 1 384 ? 95.934  97.824  123.732 1.00 24.34 ? 384 HIS A CE1   1 
ATOM   2562 N  NE2   . HIS A 1 384 ? 95.993  98.172  122.460 1.00 24.34 ? 384 HIS A NE2   1 
ATOM   2563 N  N     . LYS A 1 385 ? 90.543  100.530 125.324 1.00 24.80 ? 385 LYS A N     1 
ATOM   2564 C  CA    . LYS A 1 385 ? 89.337  101.342 125.353 1.00 24.80 ? 385 LYS A CA    1 
ATOM   2565 C  C     . LYS A 1 385 ? 89.703  102.740 124.878 1.00 24.80 ? 385 LYS A C     1 
ATOM   2566 O  O     . LYS A 1 385 ? 90.867  103.035 124.597 1.00 24.80 ? 385 LYS A O     1 
ATOM   2567 C  CB    . LYS A 1 385 ? 88.709  101.372 126.751 1.00 24.80 ? 385 LYS A CB    1 
ATOM   2568 C  CG    . LYS A 1 385 ? 88.393  100.001 127.317 1.00 24.80 ? 385 LYS A CG    1 
ATOM   2569 C  CD    . LYS A 1 385 ? 88.248  100.035 128.827 1.00 24.80 ? 385 LYS A CD    1 
ATOM   2570 C  CE    . LYS A 1 385 ? 86.966  100.729 129.243 1.00 24.80 ? 385 LYS A CE    1 
ATOM   2571 N  NZ    . LYS A 1 385 ? 86.321  100.033 130.388 1.00 24.80 ? 385 LYS A NZ    1 
ATOM   2572 N  N     . LEU A 1 386 ? 88.702  103.605 124.780 1.00 22.91 ? 386 LEU A N     1 
ATOM   2573 C  CA    . LEU A 1 386 ? 88.912  104.993 124.396 1.00 22.91 ? 386 LEU A CA    1 
ATOM   2574 C  C     . LEU A 1 386 ? 88.996  105.870 125.631 1.00 22.91 ? 386 LEU A C     1 
ATOM   2575 O  O     . LEU A 1 386 ? 88.131  105.800 126.509 1.00 22.91 ? 386 LEU A O     1 
ATOM   2576 C  CB    . LEU A 1 386 ? 87.801  105.505 123.482 1.00 22.91 ? 386 LEU A CB    1 
ATOM   2577 C  CG    . LEU A 1 386 ? 87.825  105.109 122.014 1.00 22.91 ? 386 LEU A CG    1 
ATOM   2578 C  CD1   . LEU A 1 386 ? 87.483  103.657 121.843 1.00 22.91 ? 386 LEU A CD1   1 
ATOM   2579 C  CD2   . LEU A 1 386 ? 86.854  105.987 121.251 1.00 22.91 ? 386 LEU A CD2   1 
ATOM   2580 N  N     . LYS A 1 387 ? 90.035  106.694 125.691 1.00 28.27 ? 387 LYS A N     1 
ATOM   2581 C  CA    . LYS A 1 387 ? 90.149  107.701 126.737 1.00 28.27 ? 387 LYS A CA    1 
ATOM   2582 C  C     . LYS A 1 387 ? 89.254  108.867 126.354 1.00 28.27 ? 387 LYS A C     1 
ATOM   2583 O  O     . LYS A 1 387 ? 89.578  109.646 125.458 1.00 28.27 ? 387 LYS A O     1 
ATOM   2584 C  CB    . LYS A 1 387 ? 91.593  108.150 126.911 1.00 28.27 ? 387 LYS A CB    1 
ATOM   2585 C  CG    . LYS A 1 387 ? 92.382  107.310 127.876 1.00 28.27 ? 387 LYS A CG    1 
ATOM   2586 C  CD    . LYS A 1 387 ? 93.466  108.122 128.546 1.00 28.27 ? 387 LYS A CD    1 
ATOM   2587 C  CE    . LYS A 1 387 ? 92.879  109.115 129.522 1.00 28.27 ? 387 LYS A CE    1 
ATOM   2588 N  NZ    . LYS A 1 387 ? 92.177  108.441 130.644 1.00 28.27 ? 387 LYS A NZ    1 
ATOM   2589 N  N     . LEU A 1 388 ? 88.110  108.976 127.024 1.00 28.07 ? 388 LEU A N     1 
ATOM   2590 C  CA    . LEU A 1 388 ? 87.254  110.152 126.909 1.00 28.07 ? 388 LEU A CA    1 
ATOM   2591 C  C     . LEU A 1 388 ? 87.537  111.035 128.119 1.00 28.07 ? 388 LEU A C     1 
ATOM   2592 O  O     . LEU A 1 388 ? 86.816  111.026 129.116 1.00 28.07 ? 388 LEU A O     1 
ATOM   2593 C  CB    . LEU A 1 388 ? 85.782  109.760 126.821 1.00 28.07 ? 388 LEU A CB    1 
ATOM   2594 C  CG    . LEU A 1 388 ? 85.198  109.404 125.452 1.00 28.07 ? 388 LEU A CG    1 
ATOM   2595 C  CD1   . LEU A 1 388 ? 85.280  110.598 124.537 1.00 28.07 ? 388 LEU A CD1   1 
ATOM   2596 C  CD2   . LEU A 1 388 ? 85.890  108.216 124.831 1.00 28.07 ? 388 LEU A CD2   1 
ATOM   2597 N  N     . ARG A 1 389 ? 88.624  111.806 128.021 1.00 33.14 ? 389 ARG A N     1 
ATOM   2598 C  CA    . ARG A 1 389 ? 88.974  112.716 129.105 1.00 33.14 ? 389 ARG A CA    1 
ATOM   2599 C  C     . ARG A 1 389 ? 87.898  113.767 129.311 1.00 33.14 ? 389 ARG A C     1 
ATOM   2600 O  O     . ARG A 1 389 ? 87.745  114.290 130.419 1.00 33.14 ? 389 ARG A O     1 
ATOM   2601 C  CB    . ARG A 1 389 ? 90.315  113.388 128.828 1.00 33.14 ? 389 ARG A CB    1 
ATOM   2602 C  CG    . ARG A 1 389 ? 91.519  112.481 128.949 1.00 33.14 ? 389 ARG A CG    1 
ATOM   2603 C  CD    . ARG A 1 389 ? 92.788  113.297 128.831 1.00 33.14 ? 389 ARG A CD    1 
ATOM   2604 N  NE    . ARG A 1 389 ? 93.974  112.471 128.661 1.00 33.14 ? 389 ARG A NE    1 
ATOM   2605 C  CZ    . ARG A 1 389 ? 94.460  112.101 127.486 1.00 33.14 ? 389 ARG A CZ    1 
ATOM   2606 N  NH1   . ARG A 1 389 ? 93.860  112.433 126.357 1.00 33.14 ? 389 ARG A NH1   1 
ATOM   2607 N  NH2   . ARG A 1 389 ? 95.576  111.383 127.443 1.00 33.14 ? 389 ARG A NH2   1 
ATOM   2608 N  N     . LYS A 1 390 ? 87.149  114.092 128.264 1.00 38.37 ? 390 LYS A N     1 
ATOM   2609 C  CA    . LYS A 1 390 ? 86.014  114.991 128.407 1.00 38.37 ? 390 LYS A CA    1 
ATOM   2610 C  C     . LYS A 1 390 ? 84.945  114.324 129.265 1.00 38.37 ? 390 LYS A C     1 
ATOM   2611 O  O     . LYS A 1 390 ? 84.581  113.168 129.027 1.00 38.37 ? 390 LYS A O     1 
ATOM   2612 C  CB    . LYS A 1 390 ? 85.457  115.358 127.036 1.00 38.37 ? 390 LYS A CB    1 
ATOM   2613 C  CG    . LYS A 1 390 ? 84.537  116.553 127.050 1.00 38.37 ? 390 LYS A CG    1 
ATOM   2614 C  CD    . LYS A 1 390 ? 83.975  116.830 125.676 1.00 38.37 ? 390 LYS A CD    1 
ATOM   2615 C  CE    . LYS A 1 390 ? 83.015  118.000 125.716 1.00 38.37 ? 390 LYS A CE    1 
ATOM   2616 N  NZ    . LYS A 1 390 ? 82.193  118.090 124.482 1.00 38.37 ? 390 LYS A NZ    1 
ATOM   2617 N  N     . ARG A 1 391 ? 84.448  115.044 130.271 1.00 52.38 ? 391 ARG A N     1 
ATOM   2618 C  CA    . ARG A 1 391 ? 83.447  114.462 131.158 1.00 52.38 ? 391 ARG A CA    1 
ATOM   2619 C  C     . ARG A 1 391 ? 82.104  114.316 130.457 1.00 52.38 ? 391 ARG A C     1 
ATOM   2620 O  O     . ARG A 1 391 ? 81.441  113.280 130.580 1.00 52.38 ? 391 ARG A O     1 
ATOM   2621 C  CB    . ARG A 1 391 ? 83.308  115.309 132.421 1.00 52.38 ? 391 ARG A CB    1 
ATOM   2622 C  CG    . ARG A 1 391 ? 84.459  115.143 133.400 1.00 52.38 ? 391 ARG A CG    1 
ATOM   2623 C  CD    . ARG A 1 391 ? 84.949  113.704 133.436 1.00 52.38 ? 391 ARG A CD    1 
ATOM   2624 N  NE    . ARG A 1 391 ? 85.889  113.470 134.525 1.00 52.38 ? 391 ARG A NE    1 
ATOM   2625 C  CZ    . ARG A 1 391 ? 86.766  112.477 134.555 1.00 52.38 ? 391 ARG A CZ    1 
ATOM   2626 N  NH1   . ARG A 1 391 ? 86.854  111.602 133.566 1.00 52.38 ? 391 ARG A NH1   1 
ATOM   2627 N  NH2   . ARG A 1 391 ? 87.576  112.357 135.603 1.00 52.38 ? 391 ARG A NH2   1 
ATOM   2628 N  N     . ASP A 1 392 ? 81.684  115.338 129.718 1.00 53.33 ? 392 ASP A N     1 
ATOM   2629 C  CA    . ASP A 1 392 ? 80.421  115.294 128.988 1.00 53.33 ? 392 ASP A CA    1 
ATOM   2630 C  C     . ASP A 1 392 ? 80.679  114.826 127.557 1.00 53.33 ? 392 ASP A C     1 
ATOM   2631 O  O     . ASP A 1 392 ? 80.369  115.501 126.575 1.00 53.33 ? 392 ASP A O     1 
ATOM   2632 C  CB    . ASP A 1 392 ? 79.740  116.659 129.024 1.00 53.33 ? 392 ASP A CB    1 
ATOM   2633 C  CG    . ASP A 1 392 ? 80.661  117.784 128.594 1.00 53.33 ? 392 ASP A CG    1 
ATOM   2634 O  OD1   . ASP A 1 392 ? 81.648  118.056 129.308 1.00 53.33 ? 392 ASP A OD1   1 
ATOM   2635 O  OD2   . ASP A 1 392 ? 80.394  118.402 127.543 1.00 53.33 ? 392 ASP A OD2   1 
ATOM   2636 N  N     . SER A 1 393 ? 81.263  113.634 127.462 1.00 56.41 ? 393 SER A N     1 
ATOM   2637 C  CA    . SER A 1 393 ? 81.637  113.078 126.169 1.00 56.41 ? 393 SER A CA    1 
ATOM   2638 C  C     . SER A 1 393 ? 80.398  112.809 125.326 1.00 56.41 ? 393 SER A C     1 
ATOM   2639 O  O     . SER A 1 393 ? 79.374  112.346 125.836 1.00 56.41 ? 393 SER A O     1 
ATOM   2640 C  CB    . SER A 1 393 ? 82.434  111.793 126.360 1.00 56.41 ? 393 SER A CB    1 
ATOM   2641 O  OG    . SER A 1 393 ? 81.633  110.785 126.949 1.00 56.41 ? 393 SER A OG    1 
ATOM   2642 N  N     . ARG A 1 394 ? 80.495  113.103 124.033 1.00 59.87 ? 394 ARG A N     1 
ATOM   2643 C  CA    . ARG A 1 394 ? 79.380  112.960 123.109 1.00 59.87 ? 394 ARG A CA    1 
ATOM   2644 C  C     . ARG A 1 394 ? 79.478  111.720 122.233 1.00 59.87 ? 394 ARG A C     1 
ATOM   2645 O  O     . ARG A 1 394 ? 78.565  111.470 121.441 1.00 59.87 ? 394 ARG A O     1 
ATOM   2646 C  CB    . ARG A 1 394 ? 79.282  114.199 122.216 1.00 59.87 ? 394 ARG A CB    1 
ATOM   2647 C  CG    . ARG A 1 394 ? 78.908  115.474 122.944 1.00 59.87 ? 394 ARG A CG    1 
ATOM   2648 C  CD    . ARG A 1 394 ? 78.866  116.636 121.973 1.00 59.87 ? 394 ARG A CD    1 
ATOM   2649 N  NE    . ARG A 1 394 ? 77.789  116.488 121.002 1.00 59.87 ? 394 ARG A NE    1 
ATOM   2650 C  CZ    . ARG A 1 394 ? 77.623  117.271 119.945 1.00 59.87 ? 394 ARG A CZ    1 
ATOM   2651 N  NH1   . ARG A 1 394 ? 78.446  118.275 119.693 1.00 59.87 ? 394 ARG A NH1   1 
ATOM   2652 N  NH2   . ARG A 1 394 ? 76.606  117.039 119.120 1.00 59.87 ? 394 ARG A NH2   1 
ATOM   2653 N  N     . VAL A 1 395 ? 80.547  110.942 122.349 1.00 53.63 ? 395 VAL A N     1 
ATOM   2654 C  CA    . VAL A 1 395 ? 80.754  109.787 121.487 1.00 53.63 ? 395 VAL A CA    1 
ATOM   2655 C  C     . VAL A 1 395 ? 80.534  108.522 122.301 1.00 53.63 ? 395 VAL A C     1 
ATOM   2656 O  O     . VAL A 1 395 ? 80.831  108.462 123.500 1.00 53.63 ? 395 VAL A O     1 
ATOM   2657 C  CB    . VAL A 1 395 ? 82.151  109.794 120.830 1.00 53.63 ? 395 VAL A CB    1 
ATOM   2658 C  CG1   . VAL A 1 395 ? 82.425  111.141 120.180 1.00 53.63 ? 395 VAL A CG1   1 
ATOM   2659 C  CG2   . VAL A 1 395 ? 83.229  109.456 121.836 1.00 53.63 ? 395 VAL A CG2   1 
ATOM   2660 N  N     . GLU A 1 396 ? 79.983  107.513 121.643 1.00 62.00 ? 396 GLU A N     1 
ATOM   2661 C  CA    . GLU A 1 396 ? 79.666  106.263 122.318 1.00 62.00 ? 396 GLU A CA    1 
ATOM   2662 C  C     . GLU A 1 396 ? 80.947  105.502 122.637 1.00 62.00 ? 396 GLU A C     1 
ATOM   2663 O  O     . GLU A 1 396 ? 81.772  105.288 121.742 1.00 62.00 ? 396 GLU A O     1 
ATOM   2664 C  CB    . GLU A 1 396 ? 78.743  105.408 121.452 1.00 62.00 ? 396 GLU A CB    1 
ATOM   2665 C  CG    . GLU A 1 396 ? 77.492  106.130 120.972 1.00 62.00 ? 396 GLU A CG    1 
ATOM   2666 C  CD    . GLU A 1 396 ? 77.694  106.852 119.652 1.00 62.00 ? 396 GLU A CD    1 
ATOM   2667 O  OE1   . GLU A 1 396 ? 78.829  107.294 119.377 1.00 62.00 ? 396 GLU A OE1   1 
ATOM   2668 O  OE2   . GLU A 1 396 ? 76.714  106.979 118.888 1.00 62.00 ? 396 GLU A OE2   1 
ATOM   2669 N  N     . PRO A 1 397 ? 81.159  105.097 123.887 1.00 56.74 ? 397 PRO A N     1 
ATOM   2670 C  CA    . PRO A 1 397 ? 82.350  104.305 124.208 1.00 56.74 ? 397 PRO A CA    1 
ATOM   2671 C  C     . PRO A 1 397 ? 82.350  102.997 123.435 1.00 56.74 ? 397 PRO A C     1 
ATOM   2672 O  O     . PRO A 1 397 ? 81.318  102.341 123.288 1.00 56.74 ? 397 PRO A O     1 
ATOM   2673 C  CB    . PRO A 1 397 ? 82.226  104.064 125.717 1.00 56.74 ? 397 PRO A CB    1 
ATOM   2674 C  CG    . PRO A 1 397 ? 81.233  105.069 126.200 1.00 56.74 ? 397 PRO A CG    1 
ATOM   2675 C  CD    . PRO A 1 397 ? 80.299  105.306 125.061 1.00 56.74 ? 397 PRO A CD    1 
ATOM   2676 N  N     . THR A 1 398 ? 83.523  102.620 122.939 1.00 46.74 ? 398 THR A N     1 
ATOM   2677 C  CA    . THR A 1 398 ? 83.692  101.356 122.246 1.00 46.74 ? 398 THR A CA    1 
ATOM   2678 C  C     . THR A 1 398 ? 84.867  100.617 122.861 1.00 46.74 ? 398 THR A C     1 
ATOM   2679 O  O     . THR A 1 398 ? 85.801  101.222 123.387 1.00 46.74 ? 398 THR A O     1 
ATOM   2680 C  CB    . THR A 1 398 ? 83.907  101.539 120.734 1.00 46.74 ? 398 THR A CB    1 
ATOM   2681 O  OG1   . THR A 1 398 ? 85.098  102.295 120.500 1.00 46.74 ? 398 THR A OG1   1 
ATOM   2682 C  CG2   . THR A 1 398 ? 82.726  102.259 120.104 1.00 46.74 ? 398 THR A CG2   1 
ATOM   2683 N  N     . ILE A 1 399 ? 84.799  99.293  122.799 1.00 44.38 ? 399 ILE A N     1 
ATOM   2684 C  CA    . ILE A 1 399 ? 85.785  98.427  123.429 1.00 44.38 ? 399 ILE A CA    1 
ATOM   2685 C  C     . ILE A 1 399 ? 86.375  97.515  122.364 1.00 44.38 ? 399 ILE A C     1 
ATOM   2686 O  O     . ILE A 1 399 ? 85.642  96.852  121.624 1.00 44.38 ? 399 ILE A O     1 
ATOM   2687 C  CB    . ILE A 1 399 ? 85.169  97.596  124.575 1.00 44.38 ? 399 ILE A CB    1 
ATOM   2688 C  CG1   . ILE A 1 399 ? 84.650  98.497  125.699 1.00 44.38 ? 399 ILE A CG1   1 
ATOM   2689 C  CG2   . ILE A 1 399 ? 86.184  96.636  125.127 1.00 44.38 ? 399 ILE A CG2   1 
ATOM   2690 C  CD1   . ILE A 1 399 ? 83.214  98.951  125.530 1.00 44.38 ? 399 ILE A CD1   1 
ATOM   2691 N  N     . GLY A 1 400 ? 87.702  97.474  122.295 1.00 37.00 ? 400 GLY A N     1 
ATOM   2692 C  CA    . GLY A 1 400 ? 88.374  96.636  121.334 1.00 37.00 ? 400 GLY A CA    1 
ATOM   2693 C  C     . GLY A 1 400 ? 88.330  95.178  121.727 1.00 37.00 ? 400 GLY A C     1 
ATOM   2694 O  O     . GLY A 1 400 ? 87.825  94.794  122.789 1.00 37.00 ? 400 GLY A O     1 
ATOM   2695 N  N     . PRO A 1 401 ? 88.870  94.333  120.854 1.00 34.83 ? 401 PRO A N     1 
ATOM   2696 C  CA    . PRO A 1 401 ? 88.842  92.892  121.109 1.00 34.83 ? 401 PRO A CA    1 
ATOM   2697 C  C     . PRO A 1 401 ? 89.765  92.508  122.254 1.00 34.83 ? 401 PRO A C     1 
ATOM   2698 O  O     . PRO A 1 401 ? 90.651  93.262  122.657 1.00 34.83 ? 401 PRO A O     1 
ATOM   2699 C  CB    . PRO A 1 401 ? 89.321  92.290  119.786 1.00 34.83 ? 401 PRO A CB    1 
ATOM   2700 C  CG    . PRO A 1 401 ? 90.184  93.348  119.199 1.00 34.83 ? 401 PRO A CG    1 
ATOM   2701 C  CD    . PRO A 1 401 ? 89.560  94.658  119.595 1.00 34.83 ? 401 PRO A CD    1 
ATOM   2702 N  N     . TRP A 1 402 ? 89.535  91.309  122.781 1.00 29.09 ? 402 TRP A N     1 
ATOM   2703 C  CA    . TRP A 1 402 ? 90.345  90.802  123.878 1.00 29.09 ? 402 TRP A CA    1 
ATOM   2704 C  C     . TRP A 1 402 ? 91.768  90.522  123.407 1.00 29.09 ? 402 TRP A C     1 
ATOM   2705 O  O     . TRP A 1 402 ? 92.002  90.128  122.262 1.00 29.09 ? 402 TRP A O     1 
ATOM   2706 C  CB    . TRP A 1 402 ? 89.731  89.528  124.454 1.00 29.09 ? 402 TRP A CB    1 
ATOM   2707 C  CG    . TRP A 1 402 ? 88.590  89.789  125.381 1.00 29.09 ? 402 TRP A CG    1 
ATOM   2708 C  CD1   . TRP A 1 402 ? 87.264  89.755  125.069 1.00 29.09 ? 402 TRP A CD1   1 
ATOM   2709 C  CD2   . TRP A 1 402 ? 88.668  90.153  126.763 1.00 29.09 ? 402 TRP A CD2   1 
ATOM   2710 N  NE1   . TRP A 1 402 ? 86.509  90.059  126.175 1.00 29.09 ? 402 TRP A NE1   1 
ATOM   2711 C  CE2   . TRP A 1 402 ? 87.348  90.310  127.227 1.00 29.09 ? 402 TRP A CE2   1 
ATOM   2712 C  CE3   . TRP A 1 402 ? 89.724  90.357  127.653 1.00 29.09 ? 402 TRP A CE3   1 
ATOM   2713 C  CZ2   . TRP A 1 402 ? 87.058  90.660  128.542 1.00 29.09 ? 402 TRP A CZ2   1 
ATOM   2714 C  CZ3   . TRP A 1 402 ? 89.432  90.705  128.957 1.00 29.09 ? 402 TRP A CZ3   1 
ATOM   2715 C  CH2   . TRP A 1 402 ? 88.111  90.851  129.390 1.00 29.09 ? 402 TRP A CH2   1 
ATOM   2716 N  N     . ILE A 1 403 ? 92.725  90.736  124.305 1.00 29.53 ? 403 ILE A N     1 
ATOM   2717 C  CA    . ILE A 1 403 ? 94.136  90.516  124.019 1.00 29.53 ? 403 ILE A CA    1 
ATOM   2718 C  C     . ILE A 1 403 ? 94.712  89.593  125.080 1.00 29.53 ? 403 ILE A C     1 
ATOM   2719 O  O     . ILE A 1 403 ? 94.627  89.881  126.278 1.00 29.53 ? 403 ILE A O     1 
ATOM   2720 C  CB    . ILE A 1 403 ? 94.925  91.838  123.966 1.00 29.53 ? 403 ILE A CB    1 
ATOM   2721 C  CG1   . ILE A 1 403 ? 94.249  92.828  123.018 1.00 29.53 ? 403 ILE A CG1   1 
ATOM   2722 C  CG2   . ILE A 1 403 ? 96.350  91.579  123.538 1.00 29.53 ? 403 ILE A CG2   1 
ATOM   2723 C  CD1   . ILE A 1 403 ? 94.700  94.244  123.194 1.00 29.53 ? 403 ILE A CD1   1 
ATOM   2724 N  N     . GLU A 1 404 ? 95.303  88.488  124.638 1.00 38.58 ? 404 GLU A N     1 
ATOM   2725 C  CA    . GLU A 1 404 ? 95.906  87.498  125.519 1.00 38.58 ? 404 GLU A CA    1 
ATOM   2726 C  C     . GLU A 1 404 ? 97.420  87.641  125.454 1.00 38.58 ? 404 GLU A C     1 
ATOM   2727 O  O     . GLU A 1 404 ? 98.038  87.279  124.448 1.00 38.58 ? 404 GLU A O     1 
ATOM   2728 C  CB    . GLU A 1 404 ? 95.493  86.081  125.114 1.00 38.58 ? 404 GLU A CB    1 
ATOM   2729 C  CG    . GLU A 1 404 ? 93.991  85.837  125.084 1.00 38.58 ? 404 GLU A CG    1 
ATOM   2730 C  CD    . GLU A 1 404 ? 93.355  85.907  126.455 1.00 38.58 ? 404 GLU A CD    1 
ATOM   2731 O  OE1   . GLU A 1 404 ? 94.052  85.624  127.451 1.00 38.58 ? 404 GLU A OE1   1 
ATOM   2732 O  OE2   . GLU A 1 404 ? 92.155  86.237  126.536 1.00 38.58 ? 404 GLU A OE2   1 
ATOM   2733 N  N     . ALA A 1 405 ? 98.012  88.153  126.528 1.00 38.78 ? 405 ALA A N     1 
ATOM   2734 C  CA    . ALA A 1 405 ? 99.424  88.499  126.542 1.00 38.78 ? 405 ALA A CA    1 
ATOM   2735 C  C     . ALA A 1 405 ? 100.114 87.829  127.719 1.00 38.78 ? 405 ALA A C     1 
ATOM   2736 O  O     . ALA A 1 405 ? 99.475  87.448  128.702 1.00 38.78 ? 405 ALA A O     1 
ATOM   2737 C  CB    . ALA A 1 405 ? 99.629  90.017  126.616 1.00 38.78 ? 405 ALA A CB    1 
ATOM   2738 N  N     . ALA A 1 406 ? 101.428 87.686  127.600 1.00 37.75 ? 406 ALA A N     1 
ATOM   2739 C  CA    . ALA A 1 406 ? 102.265 87.087  128.631 1.00 37.75 ? 406 ALA A CA    1 
ATOM   2740 C  C     . ALA A 1 406 ? 103.216 88.156  129.148 1.00 37.75 ? 406 ALA A C     1 
ATOM   2741 O  O     . ALA A 1 406 ? 103.736 88.959  128.367 1.00 37.75 ? 406 ALA A O     1 
ATOM   2742 C  CB    . ALA A 1 406 ? 103.029 85.889  128.081 1.00 37.75 ? 406 ALA A CB    1 
ATOM   2743 N  N     . LEU A 1 407 ? 103.430 88.178  130.459 1.00 39.56 ? 407 LEU A N     1 
ATOM   2744 C  CA    . LEU A 1 407 ? 104.314 89.146  131.091 1.00 39.56 ? 407 LEU A CA    1 
ATOM   2745 C  C     . LEU A 1 407 ? 105.460 88.436  131.799 1.00 39.56 ? 407 LEU A C     1 
ATOM   2746 O  O     . LEU A 1 407 ? 105.246 87.454  132.516 1.00 39.56 ? 407 LEU A O     1 
ATOM   2747 C  CB    . LEU A 1 407 ? 103.543 90.007  132.089 1.00 39.56 ? 407 LEU A CB    1 
ATOM   2748 C  CG    . LEU A 1 407 ? 104.333 91.124  132.758 1.00 39.56 ? 407 LEU A CG    1 
ATOM   2749 C  CD1   . LEU A 1 407 ? 104.310 92.360  131.885 1.00 39.56 ? 407 LEU A CD1   1 
ATOM   2750 C  CD2   . LEU A 1 407 ? 103.772 91.416  134.131 1.00 39.56 ? 407 LEU A CD2   1 
ATOM   2751 N  N     . ARG A 1 408 ? 106.677 88.940  131.597 1.00 39.75 ? 408 ARG A N     1 
ATOM   2752 C  CA    . ARG A 1 408 ? 107.860 88.390  132.249 1.00 39.75 ? 408 ARG A CA    1 
ATOM   2753 C  C     . ARG A 1 408 ? 108.585 89.371  133.156 1.00 39.75 ? 408 ARG A C     1 
ATOM   2754 O  O     . ARG A 1 408 ? 109.166 88.934  134.156 1.00 39.75 ? 408 ARG A O     1 
ATOM   2755 C  CB    . ARG A 1 408 ? 108.868 87.878  131.211 1.00 39.75 ? 408 ARG A CB    1 
ATOM   2756 C  CG    . ARG A 1 408 ? 108.293 87.003  130.121 1.00 39.75 ? 408 ARG A CG    1 
ATOM   2757 C  CD    . ARG A 1 408 ? 107.723 85.710  130.673 1.00 39.75 ? 408 ARG A CD    1 
ATOM   2758 N  NE    . ARG A 1 408 ? 107.677 84.645  129.675 1.00 39.75 ? 408 ARG A NE    1 
ATOM   2759 C  CZ    . ARG A 1 408 ? 106.975 84.684  128.550 1.00 39.75 ? 408 ARG A CZ    1 
ATOM   2760 N  NH1   . ARG A 1 408 ? 106.223 85.726  128.235 1.00 39.75 ? 408 ARG A NH1   1 
ATOM   2761 N  NH2   . ARG A 1 408 ? 107.026 83.649  127.718 1.00 39.75 ? 408 ARG A NH2   1 
ATOM   2762 N  N     . GLU A 1 409 ? 108.589 90.665  132.845 1.00 35.68 ? 409 GLU A N     1 
ATOM   2763 C  CA    . GLU A 1 409 ? 109.338 91.642  133.618 1.00 35.68 ? 409 GLU A CA    1 
ATOM   2764 C  C     . GLU A 1 409 ? 108.536 92.928  133.707 1.00 35.68 ? 409 GLU A C     1 
ATOM   2765 O  O     . GLU A 1 409 ? 107.530 93.104  133.018 1.00 35.68 ? 409 GLU A O     1 
ATOM   2766 C  CB    . GLU A 1 409 ? 110.710 91.933  132.997 1.00 35.68 ? 409 GLU A CB    1 
ATOM   2767 C  CG    . GLU A 1 409 ? 111.718 90.807  133.117 1.00 35.68 ? 409 GLU A CG    1 
ATOM   2768 C  CD    . GLU A 1 409 ? 113.123 91.255  132.771 1.00 35.68 ? 409 GLU A CD    1 
ATOM   2769 O  OE1   . GLU A 1 409 ? 113.263 92.182  131.949 1.00 35.68 ? 409 GLU A OE1   1 
ATOM   2770 O  OE2   . GLU A 1 409 ? 114.086 90.683  133.320 1.00 35.68 ? 409 GLU A OE2   1 
ATOM   2771 N  N     . ILE A 1 410 ? 108.990 93.826  134.581 1.00 30.69 ? 410 ILE A N     1 
ATOM   2772 C  CA    . ILE A 1 410 ? 108.456 95.177  134.676 1.00 30.69 ? 410 ILE A CA    1 
ATOM   2773 C  C     . ILE A 1 410 ? 109.633 96.141  134.735 1.00 30.69 ? 410 ILE A C     1 
ATOM   2774 O  O     . ILE A 1 410 ? 110.748 95.772  135.108 1.00 30.69 ? 410 ILE A O     1 
ATOM   2775 C  CB    . ILE A 1 410 ? 107.537 95.371  135.903 1.00 30.69 ? 410 ILE A CB    1 
ATOM   2776 C  CG1   . ILE A 1 410 ? 108.305 95.099  137.193 1.00 30.69 ? 410 ILE A CG1   1 
ATOM   2777 C  CG2   . ILE A 1 410 ? 106.324 94.466  135.815 1.00 30.69 ? 410 ILE A CG2   1 
ATOM   2778 C  CD1   . ILE A 1 410 ? 107.576 95.523  138.441 1.00 30.69 ? 410 ILE A CD1   1 
ATOM   2779 N  N     . THR A 1 411 ? 109.379 97.389  134.346 1.00 25.70 ? 411 THR A N     1 
ATOM   2780 C  CA    . THR A 1 411 ? 110.403 98.423  134.355 1.00 25.70 ? 411 THR A CA    1 
ATOM   2781 C  C     . THR A 1 411 ? 109.932 99.610  135.177 1.00 25.70 ? 411 THR A C     1 
ATOM   2782 O  O     . THR A 1 411 ? 108.779 100.033 135.068 1.00 25.70 ? 411 THR A O     1 
ATOM   2783 C  CB    . THR A 1 411 ? 110.759 98.895  132.938 1.00 25.70 ? 411 THR A CB    1 
ATOM   2784 O  OG1   . THR A 1 411 ? 109.705 99.719  132.429 1.00 25.70 ? 411 THR A OG1   1 
ATOM   2785 C  CG2   . THR A 1 411 ? 110.976 97.711  132.008 1.00 25.70 ? 411 THR A CG2   1 
ATOM   2786 N  N     . ILE A 1 412 ? 110.836 100.150 135.991 1.00 26.80 ? 412 ILE A N     1 
ATOM   2787 C  CA    . ILE A 1 412 ? 110.569 101.308 136.833 1.00 26.80 ? 412 ILE A CA    1 
ATOM   2788 C  C     . ILE A 1 412 ? 111.505 102.431 136.416 1.00 26.80 ? 412 ILE A C     1 
ATOM   2789 O  O     . ILE A 1 412 ? 112.700 102.205 136.200 1.00 26.80 ? 412 ILE A O     1 
ATOM   2790 C  CB    . ILE A 1 412 ? 110.749 100.977 138.329 1.00 26.80 ? 412 ILE A CB    1 
ATOM   2791 C  CG1   . ILE A 1 412 ? 110.092 99.639  138.654 1.00 26.80 ? 412 ILE A CG1   1 
ATOM   2792 C  CG2   . ILE A 1 412 ? 110.171 102.079 139.193 1.00 26.80 ? 412 ILE A CG2   1 
ATOM   2793 C  CD1   . ILE A 1 412 ? 110.490 99.081  139.986 1.00 26.80 ? 412 ILE A CD1   1 
ATOM   2794 N  N     . GLN A 1 413 ? 110.962 103.638 136.291 1.00 28.34 ? 413 GLN A N     1 
ATOM   2795 C  CA    . GLN A 1 413 ? 111.767 104.785 135.906 1.00 28.34 ? 413 GLN A CA    1 
ATOM   2796 C  C     . GLN A 1 413 ? 111.178 106.037 136.528 1.00 28.34 ? 413 GLN A C     1 
ATOM   2797 O  O     . GLN A 1 413 ? 110.006 106.074 136.903 1.00 28.34 ? 413 GLN A O     1 
ATOM   2798 C  CB    . GLN A 1 413 ? 111.842 104.943 134.385 1.00 28.34 ? 413 GLN A CB    1 
ATOM   2799 C  CG    . GLN A 1 413 ? 113.027 105.760 133.898 1.00 28.34 ? 413 GLN A CG    1 
ATOM   2800 C  CD    . GLN A 1 413 ? 112.968 106.055 132.416 1.00 28.34 ? 413 GLN A CD    1 
ATOM   2801 O  OE1   . GLN A 1 413 ? 111.896 106.278 131.859 1.00 28.34 ? 413 GLN A OE1   1 
ATOM   2802 N  NE2   . GLN A 1 413 ? 114.123 106.057 131.768 1.00 28.34 ? 413 GLN A NE2   1 
ATOM   2803 N  N     . LYS A 1 414 ? 112.013 107.064 136.641 1.00 28.98 ? 414 LYS A N     1 
ATOM   2804 C  CA    . LYS A 1 414 ? 111.590 108.388 137.081 1.00 28.98 ? 414 LYS A CA    1 
ATOM   2805 C  C     . LYS A 1 414 ? 111.830 109.362 135.938 1.00 28.98 ? 414 LYS A C     1 
ATOM   2806 O  O     . LYS A 1 414 ? 112.980 109.664 135.604 1.00 28.98 ? 414 LYS A O     1 
ATOM   2807 C  CB    . LYS A 1 414 ? 112.343 108.828 138.332 1.00 28.98 ? 414 LYS A CB    1 
ATOM   2808 C  CG    . LYS A 1 414 ? 112.005 110.235 138.767 1.00 28.98 ? 414 LYS A CG    1 
ATOM   2809 C  CD    . LYS A 1 414 ? 112.857 110.679 139.934 1.00 28.98 ? 414 LYS A CD    1 
ATOM   2810 C  CE    . LYS A 1 414 ? 112.408 112.037 140.434 1.00 28.98 ? 414 LYS A CE    1 
ATOM   2811 N  NZ    . LYS A 1 414 ? 111.051 111.965 141.040 1.00 28.98 ? 414 LYS A NZ    1 
ATOM   2812 N  N     . LYS A 1 415 ? 110.751 109.853 135.345 1.00 30.47 ? 415 LYS A N     1 
ATOM   2813 C  CA    . LYS A 1 415 ? 110.869 110.839 134.295 1.00 30.47 ? 415 LYS A CA    1 
ATOM   2814 C  C     . LYS A 1 415 ? 111.429 112.136 134.872 1.00 30.47 ? 415 LYS A C     1 
ATOM   2815 O  O     . LYS A 1 415 ? 111.381 112.357 136.083 1.00 30.47 ? 415 LYS A O     1 
ATOM   2816 C  CB    . LYS A 1 415 ? 109.509 111.089 133.651 1.00 30.47 ? 415 LYS A CB    1 
ATOM   2817 C  CG    . LYS A 1 415 ? 109.333 110.495 132.267 1.00 30.47 ? 415 LYS A CG    1 
ATOM   2818 C  CD    . LYS A 1 415 ? 109.770 109.050 132.207 1.00 30.47 ? 415 LYS A CD    1 
ATOM   2819 C  CE    . LYS A 1 415 ? 109.435 108.452 130.854 1.00 30.47 ? 415 LYS A CE    1 
ATOM   2820 N  NZ    . LYS A 1 415 ? 109.721 106.996 130.813 1.00 30.47 ? 415 LYS A NZ    1 
ATOM   2821 N  N     . PRO A 1 416 ? 111.990 113.002 134.025 1.00 32.59 ? 416 PRO A N     1 
ATOM   2822 C  CA    . PRO A 1 416 ? 112.513 114.279 134.532 1.00 32.59 ? 416 PRO A CA    1 
ATOM   2823 C  C     . PRO A 1 416 ? 111.472 115.142 135.222 1.00 32.59 ? 416 PRO A C     1 
ATOM   2824 O  O     . PRO A 1 416 ? 111.844 115.971 136.061 1.00 32.59 ? 416 PRO A O     1 
ATOM   2825 C  CB    . PRO A 1 416 ? 113.057 114.958 133.270 1.00 32.59 ? 416 PRO A CB    1 
ATOM   2826 C  CG    . PRO A 1 416 ? 113.402 113.830 132.370 1.00 32.59 ? 416 PRO A CG    1 
ATOM   2827 C  CD    . PRO A 1 416 ? 112.362 112.780 132.617 1.00 32.59 ? 416 PRO A CD    1 
ATOM   2828 N  N     . ASN A 1 417 ? 110.185 114.983 134.907 1.00 31.77 ? 417 ASN A N     1 
ATOM   2829 C  CA    . ASN A 1 417 ? 109.166 115.783 135.576 1.00 31.77 ? 417 ASN A CA    1 
ATOM   2830 C  C     . ASN A 1 417 ? 108.984 115.400 137.039 1.00 31.77 ? 417 ASN A C     1 
ATOM   2831 O  O     . ASN A 1 417 ? 108.313 116.133 137.772 1.00 31.77 ? 417 ASN A O     1 
ATOM   2832 C  CB    . ASN A 1 417 ? 107.827 115.671 134.841 1.00 31.77 ? 417 ASN A CB    1 
ATOM   2833 C  CG    . ASN A 1 417 ? 107.190 114.305 134.987 1.00 31.77 ? 417 ASN A CG    1 
ATOM   2834 O  OD1   . ASN A 1 417 ? 107.878 113.295 135.098 1.00 31.77 ? 417 ASN A OD1   1 
ATOM   2835 N  ND2   . ASN A 1 417 ? 105.863 114.269 134.984 1.00 31.77 ? 417 ASN A ND2   1 
ATOM   2836 N  N     . GLY A 1 418 ? 109.556 114.285 137.479 1.00 30.42 ? 418 GLY A N     1 
ATOM   2837 C  CA    . GLY A 1 418 ? 109.510 113.898 138.872 1.00 30.42 ? 418 GLY A CA    1 
ATOM   2838 C  C     . GLY A 1 418 ? 108.499 112.836 139.239 1.00 30.42 ? 418 GLY A C     1 
ATOM   2839 O  O     . GLY A 1 418 ? 108.276 112.614 140.434 1.00 30.42 ? 418 GLY A O     1 
ATOM   2840 N  N     . VAL A 1 419 ? 107.887 112.170 138.263 1.00 26.33 ? 419 VAL A N     1 
ATOM   2841 C  CA    . VAL A 1 419 ? 106.853 111.171 138.508 1.00 26.33 ? 419 VAL A CA    1 
ATOM   2842 C  C     . VAL A 1 419 ? 107.372 109.813 138.066 1.00 26.33 ? 419 VAL A C     1 
ATOM   2843 O  O     . VAL A 1 419 ? 107.879 109.671 136.949 1.00 26.33 ? 419 VAL A O     1 
ATOM   2844 C  CB    . VAL A 1 419 ? 105.548 111.522 137.775 1.00 26.33 ? 419 VAL A CB    1 
ATOM   2845 C  CG1   . VAL A 1 419 ? 104.525 110.417 137.960 1.00 26.33 ? 419 VAL A CG1   1 
ATOM   2846 C  CG2   . VAL A 1 419 ? 105.000 112.846 138.273 1.00 26.33 ? 419 VAL A CG2   1 
ATOM   2847 N  N     . PHE A 1 420 ? 107.247 108.819 138.940 1.00 26.73 ? 420 PHE A N     1 
ATOM   2848 C  CA    . PHE A 1 420 ? 107.631 107.460 138.596 1.00 26.73 ? 420 PHE A CA    1 
ATOM   2849 C  C     . PHE A 1 420 ? 106.605 106.828 137.657 1.00 26.73 ? 420 PHE A C     1 
ATOM   2850 O  O     . PHE A 1 420 ? 105.424 107.177 137.656 1.00 26.73 ? 420 PHE A O     1 
ATOM   2851 C  CB    . PHE A 1 420 ? 107.767 106.604 139.853 1.00 26.73 ? 420 PHE A CB    1 
ATOM   2852 C  CG    . PHE A 1 420 ? 108.978 106.916 140.677 1.00 26.73 ? 420 PHE A CG    1 
ATOM   2853 C  CD1   . PHE A 1 420 ? 109.011 108.031 141.492 1.00 26.73 ? 420 PHE A CD1   1 
ATOM   2854 C  CD2   . PHE A 1 420 ? 110.078 106.083 140.653 1.00 26.73 ? 420 PHE A CD2   1 
ATOM   2855 C  CE1   . PHE A 1 420 ? 110.122 108.312 142.257 1.00 26.73 ? 420 PHE A CE1   1 
ATOM   2856 C  CE2   . PHE A 1 420 ? 111.186 106.362 141.415 1.00 26.73 ? 420 PHE A CE2   1 
ATOM   2857 C  CZ    . PHE A 1 420 ? 111.209 107.478 142.217 1.00 26.73 ? 420 PHE A CZ    1 
ATOM   2858 N  N     . TYR A 1 421 ? 107.076 105.877 136.855 1.00 26.05 ? 421 TYR A N     1 
ATOM   2859 C  CA    . TYR A 1 421 ? 106.224 105.164 135.912 1.00 26.05 ? 421 TYR A CA    1 
ATOM   2860 C  C     . TYR A 1 421 ? 106.562 103.685 135.971 1.00 26.05 ? 421 TYR A C     1 
ATOM   2861 O  O     . TYR A 1 421 ? 107.737 103.322 136.061 1.00 26.05 ? 421 TYR A O     1 
ATOM   2862 C  CB    . TYR A 1 421 ? 106.418 105.684 134.487 1.00 26.05 ? 421 TYR A CB    1 
ATOM   2863 C  CG    . TYR A 1 421 ? 105.794 107.029 134.233 1.00 26.05 ? 421 TYR A CG    1 
ATOM   2864 C  CD1   . TYR A 1 421 ? 104.457 107.144 133.909 1.00 26.05 ? 421 TYR A CD1   1 
ATOM   2865 C  CD2   . TYR A 1 421 ? 106.545 108.186 134.321 1.00 26.05 ? 421 TYR A CD2   1 
ATOM   2866 C  CE1   . TYR A 1 421 ? 103.889 108.368 133.679 1.00 26.05 ? 421 TYR A CE1   1 
ATOM   2867 C  CE2   . TYR A 1 421 ? 105.985 109.415 134.094 1.00 26.05 ? 421 TYR A CE2   1 
ATOM   2868 C  CZ    . TYR A 1 421 ? 104.657 109.502 133.774 1.00 26.05 ? 421 TYR A CZ    1 
ATOM   2869 O  OH    . TYR A 1 421 ? 104.097 110.734 133.543 1.00 26.05 ? 421 TYR A OH    1 
ATOM   2870 N  N     . LEU A 1 422 ? 105.539 102.840 135.916 1.00 22.31 ? 422 LEU A N     1 
ATOM   2871 C  CA    . LEU A 1 422 ? 105.708 101.394 135.884 1.00 22.31 ? 422 LEU A CA    1 
ATOM   2872 C  C     . LEU A 1 422 ? 105.391 100.904 134.479 1.00 22.31 ? 422 LEU A C     1 
ATOM   2873 O  O     . LEU A 1 422 ? 104.329 101.220 133.937 1.00 22.31 ? 422 LEU A O     1 
ATOM   2874 C  CB    . LEU A 1 422 ? 104.801 100.715 136.906 1.00 22.31 ? 422 LEU A CB    1 
ATOM   2875 C  CG    . LEU A 1 422 ? 104.735 99.193  136.832 1.00 22.31 ? 422 LEU A CG    1 
ATOM   2876 C  CD1   . LEU A 1 422 ? 106.044 98.579  137.286 1.00 22.31 ? 422 LEU A CD1   1 
ATOM   2877 C  CD2   . LEU A 1 422 ? 103.582 98.677  137.655 1.00 22.31 ? 422 LEU A CD2   1 
ATOM   2878 N  N     . GLY A 1 423 ? 106.304 100.140 133.893 1.00 23.84 ? 423 GLY A N     1 
ATOM   2879 C  CA    . GLY A 1 423 ? 106.159 99.649  132.529 1.00 23.84 ? 423 GLY A CA    1 
ATOM   2880 C  C     . GLY A 1 423 ? 105.954 98.146  132.507 1.00 23.84 ? 423 GLY A C     1 
ATOM   2881 O  O     . GLY A 1 423 ? 106.600 97.413  133.259 1.00 23.84 ? 423 GLY A O     1 
ATOM   2882 N  N     . LEU A 1 424 ? 105.059 97.691  131.627 1.00 28.33 ? 424 LEU A N     1 
ATOM   2883 C  CA    . LEU A 1 424 ? 104.693 96.279  131.518 1.00 28.33 ? 424 LEU A CA    1 
ATOM   2884 C  C     . LEU A 1 424 ? 105.026 95.769  130.122 1.00 28.33 ? 424 LEU A C     1 
ATOM   2885 O  O     . LEU A 1 424 ? 104.204 95.875  129.199 1.00 28.33 ? 424 LEU A O     1 
ATOM   2886 C  CB    . LEU A 1 424 ? 103.212 96.074  131.829 1.00 28.33 ? 424 LEU A CB    1 
ATOM   2887 C  CG    . LEU A 1 424 ? 102.796 96.238  133.288 1.00 28.33 ? 424 LEU A CG    1 
ATOM   2888 C  CD1   . LEU A 1 424 ? 101.316 96.522  133.382 1.00 28.33 ? 424 LEU A CD1   1 
ATOM   2889 C  CD2   . LEU A 1 424 ? 103.147 95.008  134.082 1.00 28.33 ? 424 LEU A CD2   1 
ATOM   2890 N  N     . PRO A 1 425 ? 106.216 95.210  129.918 1.00 30.07 ? 425 PRO A N     1 
ATOM   2891 C  CA    . PRO A 1 425 ? 106.557 94.604  128.623 1.00 30.07 ? 425 PRO A CA    1 
ATOM   2892 C  C     . PRO A 1 425 ? 105.861 93.264  128.440 1.00 30.07 ? 425 PRO A C     1 
ATOM   2893 O  O     . PRO A 1 425 ? 106.185 92.280  129.113 1.00 30.07 ? 425 PRO A O     1 
ATOM   2894 C  CB    . PRO A 1 425 ? 108.083 94.452  128.705 1.00 30.07 ? 425 PRO A CB    1 
ATOM   2895 C  CG    . PRO A 1 425 ? 108.387 94.425  130.151 1.00 30.07 ? 425 PRO A CG    1 
ATOM   2896 C  CD    . PRO A 1 425 ? 107.377 95.294  130.817 1.00 30.07 ? 425 PRO A CD    1 
ATOM   2897 N  N     . TYR A 1 426 ? 104.907 93.219  127.511 1.00 30.29 ? 426 TYR A N     1 
ATOM   2898 C  CA    . TYR A 1 426 ? 104.083 92.043  127.272 1.00 30.29 ? 426 TYR A CA    1 
ATOM   2899 C  C     . TYR A 1 426 ? 104.310 91.512  125.863 1.00 30.29 ? 426 TYR A C     1 
ATOM   2900 O  O     . TYR A 1 426 ? 104.414 92.286  124.907 1.00 30.29 ? 426 TYR A O     1 
ATOM   2901 C  CB    . TYR A 1 426 ? 102.600 92.365  127.490 1.00 30.29 ? 426 TYR A CB    1 
ATOM   2902 C  CG    . TYR A 1 426 ? 102.047 93.424  126.563 1.00 30.29 ? 426 TYR A CG    1 
ATOM   2903 C  CD1   . TYR A 1 426 ? 102.189 94.770  126.854 1.00 30.29 ? 426 TYR A CD1   1 
ATOM   2904 C  CD2   . TYR A 1 426 ? 101.364 93.077  125.408 1.00 30.29 ? 426 TYR A CD2   1 
ATOM   2905 C  CE1   . TYR A 1 426 ? 101.682 95.737  126.015 1.00 30.29 ? 426 TYR A CE1   1 
ATOM   2906 C  CE2   . TYR A 1 426 ? 100.853 94.038  124.564 1.00 30.29 ? 426 TYR A CE2   1 
ATOM   2907 C  CZ    . TYR A 1 426 ? 101.013 95.366  124.872 1.00 30.29 ? 426 TYR A CZ    1 
ATOM   2908 O  OH    . TYR A 1 426 ? 100.507 96.326  124.031 1.00 30.29 ? 426 TYR A OH    1 
ATOM   2909 N  N     . ALA A 1 427 ? 104.373 90.186  125.741 1.00 36.84 ? 427 ALA A N     1 
ATOM   2910 C  CA    . ALA A 1 427 ? 104.675 89.503  124.487 1.00 36.84 ? 427 ALA A CA    1 
ATOM   2911 C  C     . ALA A 1 427 ? 103.427 88.800  123.969 1.00 36.84 ? 427 ALA A C     1 
ATOM   2912 O  O     . ALA A 1 427 ? 102.780 88.050  124.708 1.00 36.84 ? 427 ALA A O     1 
ATOM   2913 C  CB    . ALA A 1 427 ? 105.812 88.500  124.672 1.00 36.84 ? 427 ALA A CB    1 
ATOM   2914 N  N     . LEU A 1 428 ? 103.103 89.034  122.700 1.00 40.68 ? 428 LEU A N     1 
ATOM   2915 C  CA    . LEU A 1 428 ? 101.922 88.455  122.078 1.00 40.68 ? 428 LEU A CA    1 
ATOM   2916 C  C     . LEU A 1 428 ? 102.237 87.099  121.452 1.00 40.68 ? 428 LEU A C     1 
ATOM   2917 O  O     . LEU A 1 428 ? 103.383 86.786  121.125 1.00 40.68 ? 428 LEU A O     1 
ATOM   2918 C  CB    . LEU A 1 428 ? 101.376 89.391  121.006 1.00 40.68 ? 428 LEU A CB    1 
ATOM   2919 C  CG    . LEU A 1 428 ? 100.665 90.631  121.524 1.00 40.68 ? 428 LEU A CG    1 
ATOM   2920 C  CD1   . LEU A 1 428 ? 100.314 91.518  120.371 1.00 40.68 ? 428 LEU A CD1   1 
ATOM   2921 C  CD2   . LEU A 1 428 ? 99.426  90.233  122.279 1.00 40.68 ? 428 LEU A CD2   1 
ATOM   2922 N  N     . SER A 1 429 ? 101.192 86.295  121.271 1.00 41.15 ? 429 SER A N     1 
ATOM   2923 C  CA    . SER A 1 429 ? 101.300 84.988  120.636 1.00 41.15 ? 429 SER A CA    1 
ATOM   2924 C  C     . SER A 1 429 ? 100.502 84.997  119.342 1.00 41.15 ? 429 SER A C     1 
ATOM   2925 O  O     . SER A 1 429 ? 99.341  85.414  119.327 1.00 41.15 ? 429 SER A O     1 
ATOM   2926 C  CB    . SER A 1 429 ? 100.793 83.880  121.559 1.00 41.15 ? 429 SER A CB    1 
ATOM   2927 O  OG    . SER A 1 429 ? 99.384  83.931  121.686 1.00 41.15 ? 429 SER A OG    1 
ATOM   2928 N  N     . HIS A 1 430 ? 101.126 84.534  118.260 1.00 39.45 ? 430 HIS A N     1 
ATOM   2929 C  CA    . HIS A 1 430 ? 100.495 84.535  116.949 1.00 39.45 ? 430 HIS A CA    1 
ATOM   2930 C  C     . HIS A 1 430 ? 101.045 83.379  116.130 1.00 39.45 ? 430 HIS A C     1 
ATOM   2931 O  O     . HIS A 1 430 ? 102.087 82.803  116.452 1.00 39.45 ? 430 HIS A O     1 
ATOM   2932 C  CB    . HIS A 1 430 ? 100.727 85.856  116.211 1.00 39.45 ? 430 HIS A CB    1 
ATOM   2933 C  CG    . HIS A 1 430 ? 99.807  86.954  116.636 1.00 39.45 ? 430 HIS A CG    1 
ATOM   2934 N  ND1   . HIS A 1 430 ? 98.446  86.906  116.426 1.00 39.45 ? 430 HIS A ND1   1 
ATOM   2935 C  CD2   . HIS A 1 430 ? 100.051 88.131  117.255 1.00 39.45 ? 430 HIS A CD2   1 
ATOM   2936 C  CE1   . HIS A 1 430 ? 97.891  88.007  116.900 1.00 39.45 ? 430 HIS A CE1   1 
ATOM   2937 N  NE2   . HIS A 1 430 ? 98.844  88.767  117.408 1.00 39.45 ? 430 HIS A NE2   1 
ATOM   2938 N  N     . GLY A 1 431 ? 100.326 83.044  115.063 1.00 40.08 ? 431 GLY A N     1 
ATOM   2939 C  CA    . GLY A 1 431 ? 100.775 81.979  114.184 1.00 40.08 ? 431 GLY A CA    1 
ATOM   2940 C  C     . GLY A 1 431 ? 102.029 82.375  113.422 1.00 40.08 ? 431 GLY A C     1 
ATOM   2941 O  O     . GLY A 1 431 ? 102.130 83.471  112.869 1.00 40.08 ? 431 GLY A O     1 
ATOM   2942 N  N     . ILE A 1 432 ? 102.999 81.456  113.396 1.00 41.46 ? 432 ILE A N     1 
ATOM   2943 C  CA    . ILE A 1 432 ? 104.249 81.690  112.676 1.00 41.46 ? 432 ILE A CA    1 
ATOM   2944 C  C     . ILE A 1 432 ? 104.142 81.355  111.198 1.00 41.46 ? 432 ILE A C     1 
ATOM   2945 O  O     . ILE A 1 432 ? 105.043 81.706  110.425 1.00 41.46 ? 432 ILE A O     1 
ATOM   2946 C  CB    . ILE A 1 432 ? 105.387 80.870  113.313 1.00 41.46 ? 432 ILE A CB    1 
ATOM   2947 C  CG1   . ILE A 1 432 ? 106.755 81.455  112.953 1.00 41.46 ? 432 ILE A CG1   1 
ATOM   2948 C  CG2   . ILE A 1 432 ? 105.301 79.416  112.885 1.00 41.46 ? 432 ILE A CG2   1 
ATOM   2949 C  CD1   . ILE A 1 432 ? 107.909 80.796  113.676 1.00 41.46 ? 432 ILE A CD1   1 
ATOM   2950 N  N     . ASP A 1 433 ? 103.058 80.698  110.781 1.00 38.60 ? 433 ASP A N     1 
ATOM   2951 C  CA    . ASP A 1 433 ? 102.951 80.231  109.403 1.00 38.60 ? 433 ASP A CA    1 
ATOM   2952 C  C     . ASP A 1 433 ? 102.949 81.392  108.415 1.00 38.60 ? 433 ASP A C     1 
ATOM   2953 O  O     . ASP A 1 433 ? 103.630 81.341  107.385 1.00 38.60 ? 433 ASP A O     1 
ATOM   2954 C  CB    . ASP A 1 433 ? 101.696 79.372  109.241 1.00 38.60 ? 433 ASP A CB    1 
ATOM   2955 C  CG    . ASP A 1 433 ? 100.436 80.085  109.690 1.00 38.60 ? 433 ASP A CG    1 
ATOM   2956 O  OD1   . ASP A 1 433 ? 100.538 81.229  110.178 1.00 38.60 ? 433 ASP A OD1   1 
ATOM   2957 O  OD2   . ASP A 1 433 ? 99.342  79.500  109.559 1.00 38.60 ? 433 ASP A OD2   1 
ATOM   2958 N  N     . ASN A 1 434 ? 102.195 82.453  108.713 1.00 34.45 ? 434 ASN A N     1 
ATOM   2959 C  CA    . ASN A 1 434 ? 102.101 83.576  107.786 1.00 34.45 ? 434 ASN A CA    1 
ATOM   2960 C  C     . ASN A 1 434 ? 103.447 84.269  107.623 1.00 34.45 ? 434 ASN A C     1 
ATOM   2961 O  O     . ASN A 1 434 ? 103.852 84.613  106.505 1.00 34.45 ? 434 ASN A O     1 
ATOM   2962 C  CB    . ASN A 1 434 ? 101.046 84.567  108.269 1.00 34.45 ? 434 ASN A CB    1 
ATOM   2963 C  CG    . ASN A 1 434 ? 99.640  84.060  108.064 1.00 34.45 ? 434 ASN A CG    1 
ATOM   2964 O  OD1   . ASN A 1 434 ? 99.430  83.017  107.449 1.00 34.45 ? 434 ASN A OD1   1 
ATOM   2965 N  ND2   . ASN A 1 434 ? 98.665  84.797  108.578 1.00 34.45 ? 434 ASN A ND2   1 
ATOM   2966 N  N     . PHE A 1 435 ? 104.156 84.487  108.731 1.00 32.41 ? 435 PHE A N     1 
ATOM   2967 C  CA    . PHE A 1 435 ? 105.451 85.149  108.657 1.00 32.41 ? 435 PHE A CA    1 
ATOM   2968 C  C     . PHE A 1 435 ? 106.482 84.281  107.954 1.00 32.41 ? 435 PHE A C     1 
ATOM   2969 O  O     . PHE A 1 435 ? 107.283 84.790  107.165 1.00 32.41 ? 435 PHE A O     1 
ATOM   2970 C  CB    . PHE A 1 435 ? 105.914 85.535  110.060 1.00 32.41 ? 435 PHE A CB    1 
ATOM   2971 C  CG    . PHE A 1 435 ? 104.945 86.424  110.788 1.00 32.41 ? 435 PHE A CG    1 
ATOM   2972 C  CD1   . PHE A 1 435 ? 104.860 87.768  110.483 1.00 32.41 ? 435 PHE A CD1   1 
ATOM   2973 C  CD2   . PHE A 1 435 ? 104.101 85.911  111.756 1.00 32.41 ? 435 PHE A CD2   1 
ATOM   2974 C  CE1   . PHE A 1 435 ? 103.968 88.584  111.140 1.00 32.41 ? 435 PHE A CE1   1 
ATOM   2975 C  CE2   . PHE A 1 435 ? 103.206 86.726  112.415 1.00 32.41 ? 435 PHE A CE2   1 
ATOM   2976 C  CZ    . PHE A 1 435 ? 103.141 88.062  112.107 1.00 32.41 ? 435 PHE A CZ    1 
ATOM   2977 N  N     . GLN A 1 436 ? 106.468 82.970  108.203 1.00 36.13 ? 436 GLN A N     1 
ATOM   2978 C  CA    . GLN A 1 436 ? 107.370 82.086  107.473 1.00 36.13 ? 436 GLN A CA    1 
ATOM   2979 C  C     . GLN A 1 436 ? 107.054 82.068  105.985 1.00 36.13 ? 436 GLN A C     1 
ATOM   2980 O  O     . GLN A 1 436 ? 107.972 81.987  105.162 1.00 36.13 ? 436 GLN A O     1 
ATOM   2981 C  CB    . GLN A 1 436 ? 107.308 80.668  108.042 1.00 36.13 ? 436 GLN A CB    1 
ATOM   2982 C  CG    . GLN A 1 436 ? 107.833 80.517  109.468 1.00 36.13 ? 436 GLN A CG    1 
ATOM   2983 C  CD    . GLN A 1 436 ? 109.329 80.768  109.609 1.00 36.13 ? 436 GLN A CD    1 
ATOM   2984 O  OE1   . GLN A 1 436 ? 109.987 81.268  108.697 1.00 36.13 ? 436 GLN A OE1   1 
ATOM   2985 N  NE2   . GLN A 1 436 ? 109.871 80.418  110.768 1.00 36.13 ? 436 GLN A NE2   1 
ATOM   2986 N  N     . ILE A 1 437 ? 105.773 82.134  105.622 1.00 34.14 ? 437 ILE A N     1 
ATOM   2987 C  CA    . ILE A 1 437 ? 105.394 82.162  104.214 1.00 34.14 ? 437 ILE A CA    1 
ATOM   2988 C  C     . ILE A 1 437 ? 105.893 83.441  103.555 1.00 34.14 ? 437 ILE A C     1 
ATOM   2989 O  O     . ILE A 1 437 ? 106.467 83.413  102.461 1.00 34.14 ? 437 ILE A O     1 
ATOM   2990 C  CB    . ILE A 1 437 ? 103.870 82.012  104.072 1.00 34.14 ? 437 ILE A CB    1 
ATOM   2991 C  CG1   . ILE A 1 437 ? 103.467 80.543  104.181 1.00 34.14 ? 437 ILE A CG1   1 
ATOM   2992 C  CG2   . ILE A 1 437 ? 103.393 82.595  102.755 1.00 34.14 ? 437 ILE A CG2   1 
ATOM   2993 C  CD1   . ILE A 1 437 ? 102.001 80.340  104.473 1.00 34.14 ? 437 ILE A CD1   1 
ATOM   2994 N  N     . ALA A 1 438 ? 105.695 84.582  104.216 1.00 31.14 ? 438 ALA A N     1 
ATOM   2995 C  CA    . ALA A 1 438 ? 106.121 85.851  103.636 1.00 31.14 ? 438 ALA A CA    1 
ATOM   2996 C  C     . ALA A 1 438 ? 107.628 86.054  103.710 1.00 31.14 ? 438 ALA A C     1 
ATOM   2997 O  O     . ALA A 1 438 ? 108.151 86.953  103.045 1.00 31.14 ? 438 ALA A O     1 
ATOM   2998 C  CB    . ALA A 1 438 ? 105.414 87.015  104.326 1.00 31.14 ? 438 ALA A CB    1 
ATOM   2999 N  N     . LYS A 1 439 ? 108.334 85.257  104.513 1.00 36.01 ? 439 LYS A N     1 
ATOM   3000 C  CA    . LYS A 1 439 ? 109.776 85.432  104.637 1.00 36.01 ? 439 LYS A CA    1 
ATOM   3001 C  C     . LYS A 1 439 ? 110.524 84.670  103.552 1.00 36.01 ? 439 LYS A C     1 
ATOM   3002 O  O     . LYS A 1 439 ? 111.226 85.272  102.733 1.00 36.01 ? 439 LYS A O     1 
ATOM   3003 C  CB    . LYS A 1 439 ? 110.234 84.980  106.026 1.00 36.01 ? 439 LYS A CB    1 
ATOM   3004 C  CG    . LYS A 1 439 ? 111.734 85.055  106.272 1.00 36.01 ? 439 LYS A CG    1 
ATOM   3005 C  CD    . LYS A 1 439 ? 112.318 86.394  105.873 1.00 36.01 ? 439 LYS A CD    1 
ATOM   3006 C  CE    . LYS A 1 439 ? 113.832 86.320  105.811 1.00 36.01 ? 439 LYS A CE    1 
ATOM   3007 N  NZ    . LYS A 1 439 ? 114.424 86.033  107.146 1.00 36.01 ? 439 LYS A NZ    1 
ATOM   3008 N  N     . ARG A 1 440 ? 110.382 83.344  103.521 1.00 38.13 ? 440 ARG A N     1 
ATOM   3009 C  CA    . ARG A 1 440 ? 111.207 82.525  102.643 1.00 38.13 ? 440 ARG A CA    1 
ATOM   3010 C  C     . ARG A 1 440 ? 110.644 82.343  101.247 1.00 38.13 ? 440 ARG A C     1 
ATOM   3011 O  O     . ARG A 1 440 ? 111.420 82.143  100.312 1.00 38.13 ? 440 ARG A O     1 
ATOM   3012 C  CB    . ARG A 1 440 ? 111.442 81.129  103.236 1.00 38.13 ? 440 ARG A CB    1 
ATOM   3013 C  CG    . ARG A 1 440 ? 112.462 81.055  104.355 1.00 38.13 ? 440 ARG A CG    1 
ATOM   3014 C  CD    . ARG A 1 440 ? 111.842 81.434  105.669 1.00 38.13 ? 440 ARG A CD    1 
ATOM   3015 N  NE    . ARG A 1 440 ? 110.720 80.546  105.939 1.00 38.13 ? 440 ARG A NE    1 
ATOM   3016 C  CZ    . ARG A 1 440 ? 110.834 79.350  106.499 1.00 38.13 ? 440 ARG A CZ    1 
ATOM   3017 N  NH1   . ARG A 1 440 ? 112.009 78.875  106.879 1.00 38.13 ? 440 ARG A NH1   1 
ATOM   3018 N  NH2   . ARG A 1 440 ? 109.744 78.610  106.677 1.00 38.13 ? 440 ARG A NH2   1 
ATOM   3019 N  N     . PHE A 1 441 ? 109.325 82.392  101.072 1.00 35.91 ? 441 PHE A N     1 
ATOM   3020 C  CA    . PHE A 1 441 ? 108.773 82.109  99.753  1.00 35.91 ? 441 PHE A CA    1 
ATOM   3021 C  C     . PHE A 1 441 ? 108.641 83.375  98.914  1.00 35.91 ? 441 PHE A C     1 
ATOM   3022 O  O     . PHE A 1 441 ? 109.268 83.490  97.857  1.00 35.91 ? 441 PHE A O     1 
ATOM   3023 C  CB    . PHE A 1 441 ? 107.418 81.403  99.872  1.00 35.91 ? 441 PHE A CB    1 
ATOM   3024 C  CG    . PHE A 1 441 ? 106.828 81.016  98.544  1.00 35.91 ? 441 PHE A CG    1 
ATOM   3025 C  CD1   . PHE A 1 441 ? 107.375 79.980  97.807  1.00 35.91 ? 441 PHE A CD1   1 
ATOM   3026 C  CD2   . PHE A 1 441 ? 105.737 81.687  98.028  1.00 35.91 ? 441 PHE A CD2   1 
ATOM   3027 C  CE1   . PHE A 1 441 ? 106.845 79.620  96.588  1.00 35.91 ? 441 PHE A CE1   1 
ATOM   3028 C  CE2   . PHE A 1 441 ? 105.202 81.329  96.806  1.00 35.91 ? 441 PHE A CE2   1 
ATOM   3029 C  CZ    . PHE A 1 441 ? 105.757 80.294  96.088  1.00 35.91 ? 441 PHE A CZ    1 
ATOM   3030 N  N     . PHE A 1 442 ? 107.860 84.340  99.379  1.00 30.75 ? 442 PHE A N     1 
ATOM   3031 C  CA    . PHE A 1 442 ? 107.553 85.492  98.546  1.00 30.75 ? 442 PHE A CA    1 
ATOM   3032 C  C     . PHE A 1 442 ? 108.685 86.505  98.487  1.00 30.75 ? 442 PHE A C     1 
ATOM   3033 O  O     . PHE A 1 442 ? 108.559 87.501  97.767  1.00 30.75 ? 442 PHE A O     1 
ATOM   3034 C  CB    . PHE A 1 442 ? 106.269 86.165  99.025  1.00 30.75 ? 442 PHE A CB    1 
ATOM   3035 C  CG    . PHE A 1 442 ? 105.022 85.424  98.641  1.00 30.75 ? 442 PHE A CG    1 
ATOM   3036 C  CD1   . PHE A 1 442 ? 104.637 85.334  97.316  1.00 30.75 ? 442 PHE A CD1   1 
ATOM   3037 C  CD2   . PHE A 1 442 ? 104.227 84.834  99.601  1.00 30.75 ? 442 PHE A CD2   1 
ATOM   3038 C  CE1   . PHE A 1 442 ? 103.495 84.658  96.957  1.00 30.75 ? 442 PHE A CE1   1 
ATOM   3039 C  CE2   . PHE A 1 442 ? 103.081 84.161  99.245  1.00 30.75 ? 442 PHE A CE2   1 
ATOM   3040 C  CZ    . PHE A 1 442 ? 102.716 84.074  97.921  1.00 30.75 ? 442 PHE A CZ    1 
ATOM   3041 N  N     . SER A 1 443 ? 109.776 86.286  99.221  1.00 31.22 ? 443 SER A N     1 
ATOM   3042 C  CA    . SER A 1 443 ? 110.934 87.165  99.168  1.00 31.22 ? 443 SER A CA    1 
ATOM   3043 C  C     . SER A 1 443 ? 112.171 86.520  98.567  1.00 31.22 ? 443 SER A C     1 
ATOM   3044 O  O     . SER A 1 443 ? 113.249 87.117  98.639  1.00 31.22 ? 443 SER A O     1 
ATOM   3045 C  CB    . SER A 1 443 ? 111.283 87.687  100.570 1.00 31.22 ? 443 SER A CB    1 
ATOM   3046 O  OG    . SER A 1 443 ? 110.296 88.587  101.042 1.00 31.22 ? 443 SER A OG    1 
ATOM   3047 N  N     . ALA A 1 444 ? 112.060 85.329  97.992  1.00 38.93 ? 444 ALA A N     1 
ATOM   3048 C  CA    . ALA A 1 444 ? 113.203 84.638  97.419  1.00 38.93 ? 444 ALA A CA    1 
ATOM   3049 C  C     . ALA A 1 444 ? 112.862 84.127  96.028  1.00 38.93 ? 444 ALA A C     1 
ATOM   3050 O  O     . ALA A 1 444 ? 111.771 83.601  95.792  1.00 38.93 ? 444 ALA A O     1 
ATOM   3051 C  CB    . ALA A 1 444 ? 113.654 83.471  98.305  1.00 38.93 ? 444 ALA A CB    1 
ATOM   3052 N  N     . ALA A 1 445 ? 113.811 84.290  95.106  1.00 43.62 ? 445 ALA A N     1 
ATOM   3053 C  CA    . ALA A 1 445 ? 113.683 83.718  93.773  1.00 43.62 ? 445 ALA A CA    1 
ATOM   3054 C  C     . ALA A 1 445 ? 113.944 82.217  93.749  1.00 43.62 ? 445 ALA A C     1 
ATOM   3055 O  O     . ALA A 1 445 ? 113.537 81.552  92.793  1.00 43.62 ? 445 ALA A O     1 
ATOM   3056 C  CB    . ALA A 1 445 ? 114.633 84.424  92.806  1.00 43.62 ? 445 ALA A CB    1 
ATOM   3057 N  N     . LYS A 1 446 ? 114.582 81.673  94.785  1.00 52.02 ? 446 LYS A N     1 
ATOM   3058 C  CA    . LYS A 1 446 ? 114.831 80.238  94.938  1.00 52.02 ? 446 LYS A CA    1 
ATOM   3059 C  C     . LYS A 1 446 ? 114.198 79.734  96.227  1.00 52.02 ? 446 LYS A C     1 
ATOM   3060 O  O     . LYS A 1 446 ? 114.890 79.515  97.228  1.00 52.02 ? 446 LYS A O     1 
ATOM   3061 C  CB    . LYS A 1 446 ? 116.330 79.927  94.940  1.00 52.02 ? 446 LYS A CB    1 
ATOM   3062 C  CG    . LYS A 1 446 ? 117.143 80.274  93.698  1.00 52.02 ? 446 LYS A CG    1 
ATOM   3063 C  CD    . LYS A 1 446 ? 116.822 79.336  92.533  1.00 52.02 ? 446 LYS A CD    1 
ATOM   3064 C  CE    . LYS A 1 446 ? 115.761 79.857  91.606  1.00 52.02 ? 446 LYS A CE    1 
ATOM   3065 N  NZ    . LYS A 1 446 ? 115.556 78.966  90.431  1.00 52.02 ? 446 LYS A NZ    1 
ATOM   3066 N  N     . PRO A 1 447 ? 112.883 79.533  96.239  1.00 49.27 ? 447 PRO A N     1 
ATOM   3067 C  CA    . PRO A 1 447 ? 112.271 78.808  97.356  1.00 49.27 ? 447 PRO A CA    1 
ATOM   3068 C  C     . PRO A 1 447 ? 112.559 77.322  97.219  1.00 49.27 ? 447 PRO A C     1 
ATOM   3069 O  O     . PRO A 1 447 ? 112.192 76.697  96.222  1.00 49.27 ? 447 PRO A O     1 
ATOM   3070 C  CB    . PRO A 1 447 ? 110.776 79.115  97.210  1.00 49.27 ? 447 PRO A CB    1 
ATOM   3071 C  CG    . PRO A 1 447 ? 110.693 80.232  96.214  1.00 49.27 ? 447 PRO A CG    1 
ATOM   3072 C  CD    . PRO A 1 447 ? 111.866 80.056  95.317  1.00 49.27 ? 447 PRO A CD    1 
ATOM   3073 N  N     . ASP A 1 448 ? 113.235 76.760  98.217  1.00 61.88 ? 448 ASP A N     1 
ATOM   3074 C  CA    . ASP A 1 448 ? 113.616 75.359  98.155  1.00 61.88 ? 448 ASP A CA    1 
ATOM   3075 C  C     . ASP A 1 448 ? 112.376 74.470  98.264  1.00 61.88 ? 448 ASP A C     1 
ATOM   3076 O  O     . ASP A 1 448 ? 111.329 74.873  98.779  1.00 61.88 ? 448 ASP A O     1 
ATOM   3077 C  CB    . ASP A 1 448 ? 114.663 75.047  99.224  1.00 61.88 ? 448 ASP A CB    1 
ATOM   3078 C  CG    . ASP A 1 448 ? 114.216 75.438  100.614 1.00 61.88 ? 448 ASP A CG    1 
ATOM   3079 O  OD1   . ASP A 1 448 ? 113.091 75.949  100.755 1.00 61.88 ? 448 ASP A OD1   1 
ATOM   3080 O  OD2   . ASP A 1 448 ? 115.001 75.249  101.567 1.00 61.88 ? 448 ASP A OD2   1 
ATOM   3081 N  N     . LYS A 1 449 ? 112.513 73.233  97.777  1.00 64.03 ? 449 LYS A N     1 
ATOM   3082 C  CA    . LYS A 1 449 ? 111.354 72.395  97.478  1.00 64.03 ? 449 LYS A CA    1 
ATOM   3083 C  C     . LYS A 1 449 ? 110.484 72.154  98.707  1.00 64.03 ? 449 LYS A C     1 
ATOM   3084 O  O     . LYS A 1 449 ? 109.260 72.009  98.587  1.00 64.03 ? 449 LYS A O     1 
ATOM   3085 C  CB    . LYS A 1 449 ? 111.820 71.068  96.881  1.00 64.03 ? 449 LYS A CB    1 
ATOM   3086 C  CG    . LYS A 1 449 ? 112.548 71.221  95.556  1.00 64.03 ? 449 LYS A CG    1 
ATOM   3087 C  CD    . LYS A 1 449 ? 113.350 69.979  95.219  1.00 64.03 ? 449 LYS A CD    1 
ATOM   3088 C  CE    . LYS A 1 449 ? 114.603 69.889  96.074  1.00 64.03 ? 449 LYS A CE    1 
ATOM   3089 N  NZ    . LYS A 1 449 ? 115.525 71.033  95.829  1.00 64.03 ? 449 LYS A NZ    1 
ATOM   3090 N  N     . GLU A 1 450 ? 111.091 72.104  99.894  1.00 65.35 ? 450 GLU A N     1 
ATOM   3091 C  CA    . GLU A 1 450 ? 110.304 71.861  101.098 1.00 65.35 ? 450 GLU A CA    1 
ATOM   3092 C  C     . GLU A 1 450 ? 109.343 73.011  101.380 1.00 65.35 ? 450 GLU A C     1 
ATOM   3093 O  O     . GLU A 1 450 ? 108.296 72.806  102.003 1.00 65.35 ? 450 GLU A O     1 
ATOM   3094 C  CB    . GLU A 1 450 ? 111.225 71.606  102.291 1.00 65.35 ? 450 GLU A CB    1 
ATOM   3095 C  CG    . GLU A 1 450 ? 112.298 72.652  102.512 1.00 65.35 ? 450 GLU A CG    1 
ATOM   3096 C  CD    . GLU A 1 450 ? 113.627 72.244  101.912 1.00 65.35 ? 450 GLU A CD    1 
ATOM   3097 O  OE1   . GLU A 1 450 ? 113.623 71.482  100.923 1.00 65.35 ? 450 GLU A OE1   1 
ATOM   3098 O  OE2   . GLU A 1 450 ? 114.675 72.668  102.439 1.00 65.35 ? 450 GLU A OE2   1 
ATOM   3099 N  N     . VAL A 1 451 ? 109.667 74.225  100.923 1.00 55.85 ? 451 VAL A N     1 
ATOM   3100 C  CA    . VAL A 1 451 ? 108.731 75.334  101.099 1.00 55.85 ? 451 VAL A CA    1 
ATOM   3101 C  C     . VAL A 1 451 ? 107.510 75.172  100.202 1.00 55.85 ? 451 VAL A C     1 
ATOM   3102 O  O     . VAL A 1 451 ? 106.375 75.372  100.654 1.00 55.85 ? 451 VAL A O     1 
ATOM   3103 C  CB    . VAL A 1 451 ? 109.429 76.684  100.860 1.00 55.85 ? 451 VAL A CB    1 
ATOM   3104 C  CG1   . VAL A 1 451 ? 108.408 77.807  100.856 1.00 55.85 ? 451 VAL A CG1   1 
ATOM   3105 C  CG2   . VAL A 1 451 ? 110.448 76.934  101.948 1.00 55.85 ? 451 VAL A CG2   1 
ATOM   3106 N  N     . ILE A 1 452 ? 107.706 74.811  98.930  1.00 54.85 ? 452 ILE A N     1 
ATOM   3107 C  CA    . ILE A 1 452 ? 106.561 74.596  98.047  1.00 54.85 ? 452 ILE A CA    1 
ATOM   3108 C  C     . ILE A 1 452 ? 105.717 73.433  98.549  1.00 54.85 ? 452 ILE A C     1 
ATOM   3109 O  O     . ILE A 1 452 ? 104.482 73.500  98.554  1.00 54.85 ? 452 ILE A O     1 
ATOM   3110 C  CB    . ILE A 1 452 ? 107.004 74.373  96.586  1.00 54.85 ? 452 ILE A CB    1 
ATOM   3111 C  CG1   . ILE A 1 452 ? 107.931 75.486  96.086  1.00 54.85 ? 452 ILE A CG1   1 
ATOM   3112 C  CG2   . ILE A 1 452 ? 105.793 74.262  95.676  1.00 54.85 ? 452 ILE A CG2   1 
ATOM   3113 C  CD1   . ILE A 1 452 ? 109.391 75.270  96.377  1.00 54.85 ? 452 ILE A CD1   1 
ATOM   3114 N  N     . ASN A 1 453 ? 106.365 72.349  98.977  1.00 58.82 ? 453 ASN A N     1 
ATOM   3115 C  CA    . ASN A 1 453 ? 105.611 71.234  99.538  1.00 58.82 ? 453 ASN A CA    1 
ATOM   3116 C  C     . ASN A 1 453 ? 104.987 71.595  100.880 1.00 58.82 ? 453 ASN A C     1 
ATOM   3117 O  O     . ASN A 1 453 ? 104.072 70.904  101.342 1.00 58.82 ? 453 ASN A O     1 
ATOM   3118 C  CB    . ASN A 1 453 ? 106.508 70.006  99.673  1.00 58.82 ? 453 ASN A CB    1 
ATOM   3119 C  CG    . ASN A 1 453 ? 107.048 69.532  98.340  1.00 58.82 ? 453 ASN A CG    1 
ATOM   3120 O  OD1   . ASN A 1 453 ? 108.259 69.501  98.121  1.00 58.82 ? 453 ASN A OD1   1 
ATOM   3121 N  ND2   . ASN A 1 453 ? 106.147 69.167  97.435  1.00 58.82 ? 453 ASN A ND2   1 
ATOM   3122 N  N     . GLY A 1 454 ? 105.469 72.662  101.520 1.00 52.52 ? 454 GLY A N     1 
ATOM   3123 C  CA    . GLY A 1 454 ? 104.890 73.150  102.756 1.00 52.52 ? 454 GLY A CA    1 
ATOM   3124 C  C     . GLY A 1 454 ? 103.908 74.289  102.604 1.00 52.52 ? 454 GLY A C     1 
ATOM   3125 O  O     . GLY A 1 454 ? 103.294 74.693  103.596 1.00 52.52 ? 454 GLY A O     1 
ATOM   3126 N  N     . LEU A 1 455 ? 103.753 74.824  101.399 1.00 45.96 ? 455 LEU A N     1 
ATOM   3127 C  CA    . LEU A 1 455 ? 102.760 75.861  101.176 1.00 45.96 ? 455 LEU A CA    1 
ATOM   3128 C  C     . LEU A 1 455 ? 101.357 75.285  101.349 1.00 45.96 ? 455 LEU A C     1 
ATOM   3129 O  O     . LEU A 1 455 ? 101.133 74.103  101.077 1.00 45.96 ? 455 LEU A O     1 
ATOM   3130 C  CB    . LEU A 1 455 ? 102.903 76.456  99.775  1.00 45.96 ? 455 LEU A CB    1 
ATOM   3131 C  CG    . LEU A 1 455 ? 104.030 77.448  99.493  1.00 45.96 ? 455 LEU A CG    1 
ATOM   3132 C  CD1   . LEU A 1 455 ? 104.196 77.642  97.999  1.00 45.96 ? 455 LEU A CD1   1 
ATOM   3133 C  CD2   . LEU A 1 455 ? 103.736 78.776  100.162 1.00 45.96 ? 455 LEU A CD2   1 
ATOM   3134 N  N     . PRO A 1 456 ? 100.399 76.086  101.802 1.00 45.72 ? 456 PRO A N     1 
ATOM   3135 C  CA    . PRO A 1 456 ? 99.011  75.612  101.861 1.00 45.72 ? 456 PRO A CA    1 
ATOM   3136 C  C     . PRO A 1 456 ? 98.374  75.534  100.483 1.00 45.72 ? 456 PRO A C     1 
ATOM   3137 O  O     . PRO A 1 456 ? 99.048  75.730  99.468  1.00 45.72 ? 456 PRO A O     1 
ATOM   3138 C  CB    . PRO A 1 456 ? 98.320  76.660  102.742 1.00 45.72 ? 456 PRO A CB    1 
ATOM   3139 C  CG    . PRO A 1 456 ? 99.148  77.888  102.584 1.00 45.72 ? 456 PRO A CG    1 
ATOM   3140 C  CD    . PRO A 1 456 ? 100.561 77.415  102.414 1.00 45.72 ? 456 PRO A CD    1 
ATOM   3141 N  N     . SER A 1 457 ? 97.076  75.243  100.434 1.00 43.93 ? 457 SER A N     1 
ATOM   3142 C  CA    . SER A 1 457 ? 96.334  75.169  99.183  1.00 43.93 ? 457 SER A CA    1 
ATOM   3143 C  C     . SER A 1 457 ? 95.374  76.336  98.998  1.00 43.93 ? 457 SER A C     1 
ATOM   3144 O  O     . SER A 1 457 ? 94.453  76.245  98.181  1.00 43.93 ? 457 SER A O     1 
ATOM   3145 C  CB    . SER A 1 457 ? 95.570  73.846  99.105  1.00 43.93 ? 457 SER A CB    1 
ATOM   3146 O  OG    . SER A 1 457 ? 94.492  73.827  100.024 1.00 43.93 ? 457 SER A OG    1 
ATOM   3147 N  N     . GLU A 1 458 ? 95.567  77.426  99.735  1.00 44.08 ? 458 GLU A N     1 
ATOM   3148 C  CA    . GLU A 1 458 ? 94.636  78.544  99.723  1.00 44.08 ? 458 GLU A CA    1 
ATOM   3149 C  C     . GLU A 1 458 ? 95.268  79.724  100.440 1.00 44.08 ? 458 GLU A C     1 
ATOM   3150 O  O     . GLU A 1 458 ? 95.866  79.557  101.505 1.00 44.08 ? 458 GLU A O     1 
ATOM   3151 C  CB    . GLU A 1 458 ? 93.314  78.161  100.401 1.00 44.08 ? 458 GLU A CB    1 
ATOM   3152 C  CG    . GLU A 1 458 ? 92.267  79.260  100.428 1.00 44.08 ? 458 GLU A CG    1 
ATOM   3153 C  CD    . GLU A 1 458 ? 91.775  79.645  99.054  1.00 44.08 ? 458 GLU A CD    1 
ATOM   3154 O  OE1   . GLU A 1 458 ? 91.839  78.800  98.137  1.00 44.08 ? 458 GLU A OE1   1 
ATOM   3155 O  OE2   . GLU A 1 458 ? 91.316  80.793  98.896  1.00 44.08 ? 458 GLU A OE2   1 
ATOM   3156 N  N     . MET A 1 459 ? 95.130  80.910  99.851  1.00 37.84 ? 459 MET A N     1 
ATOM   3157 C  CA    . MET A 1 459 ? 95.588  82.143  100.471 1.00 37.84 ? 459 MET A CA    1 
ATOM   3158 C  C     . MET A 1 459 ? 94.683  83.280  100.031 1.00 37.84 ? 459 MET A C     1 
ATOM   3159 O  O     . MET A 1 459 ? 94.013  83.205  98.999  1.00 37.84 ? 459 MET A O     1 
ATOM   3160 C  CB    . MET A 1 459 ? 97.039  82.488  100.105 1.00 37.84 ? 459 MET A CB    1 
ATOM   3161 C  CG    . MET A 1 459 ? 98.105  81.556  100.643 1.00 37.84 ? 459 MET A CG    1 
ATOM   3162 S  SD    . MET A 1 459 ? 99.741  82.093  100.118 1.00 37.84 ? 459 MET A SD    1 
ATOM   3163 C  CE    . MET A 1 459 ? 100.765 80.793  100.790 1.00 37.84 ? 459 MET A CE    1 
ATOM   3164 N  N     . VAL A 1 460 ? 94.669  84.337  100.835 1.00 27.71 ? 460 VAL A N     1 
ATOM   3165 C  CA    . VAL A 1 460 ? 94.112  85.625  100.450 1.00 27.71 ? 460 VAL A CA    1 
ATOM   3166 C  C     . VAL A 1 460 ? 95.225  86.649  100.592 1.00 27.71 ? 460 VAL A C     1 
ATOM   3167 O  O     . VAL A 1 460 ? 95.832  86.762  101.662 1.00 27.71 ? 460 VAL A O     1 
ATOM   3168 C  CB    . VAL A 1 460 ? 92.894  86.009  101.310 1.00 27.71 ? 460 VAL A CB    1 
ATOM   3169 C  CG1   . VAL A 1 460 ? 92.357  87.365  100.891 1.00 27.71 ? 460 VAL A CG1   1 
ATOM   3170 C  CG2   . VAL A 1 460 ? 91.814  84.952  101.197 1.00 27.71 ? 460 VAL A CG2   1 
ATOM   3171 N  N     . VAL A 1 461 ? 95.503  87.379  99.514  1.00 22.90 ? 461 VAL A N     1 
ATOM   3172 C  CA    . VAL A 1 461 ? 96.624  88.306  99.476  1.00 22.90 ? 461 VAL A CA    1 
ATOM   3173 C  C     . VAL A 1 461 ? 96.118  89.681  99.076  1.00 22.90 ? 461 VAL A C     1 
ATOM   3174 O  O     . VAL A 1 461 ? 95.022  89.837  98.536  1.00 22.90 ? 461 VAL A O     1 
ATOM   3175 C  CB    . VAL A 1 461 ? 97.739  87.842  98.514  1.00 22.90 ? 461 VAL A CB    1 
ATOM   3176 C  CG1   . VAL A 1 461 ? 98.489  86.666  99.104  1.00 22.90 ? 461 VAL A CG1   1 
ATOM   3177 C  CG2   . VAL A 1 461 ? 97.158  87.477  97.165  1.00 22.90 ? 461 VAL A CG2   1 
ATOM   3178 N  N     . GLY A 1 462 ? 96.939  90.689  99.356  1.00 18.96 ? 462 GLY A N     1 
ATOM   3179 C  CA    . GLY A 1 462 ? 96.578  92.058  99.062  1.00 18.96 ? 462 GLY A CA    1 
ATOM   3180 C  C     . GLY A 1 462 ? 97.800  92.858  98.678  1.00 18.96 ? 462 GLY A C     1 
ATOM   3181 O  O     . GLY A 1 462 ? 98.937  92.410  98.829  1.00 18.96 ? 462 GLY A O     1 
ATOM   3182 N  N     . ALA A 1 463 ? 97.547  94.057  98.166  1.00 19.11 ? 463 ALA A N     1 
ATOM   3183 C  CA    . ALA A 1 463 ? 98.615  94.964  97.781  1.00 19.11 ? 463 ALA A CA    1 
ATOM   3184 C  C     . ALA A 1 463 ? 98.143  96.389  98.001  1.00 19.11 ? 463 ALA A C     1 
ATOM   3185 O  O     . ALA A 1 463 ? 96.947  96.682  97.947  1.00 19.11 ? 463 ALA A O     1 
ATOM   3186 C  CB    . ALA A 1 463 ? 99.037  94.757  96.324  1.00 19.11 ? 463 ALA A CB    1 
ATOM   3187 N  N     . ALA A 1 464 ? 99.098  97.278  98.250  1.00 20.33 ? 464 ALA A N     1 
ATOM   3188 C  CA    . ALA A 1 464 ? 98.773  98.668  98.515  1.00 20.33 ? 464 ALA A CA    1 
ATOM   3189 C  C     . ALA A 1 464 ? 99.776  99.571  97.816  1.00 20.33 ? 464 ALA A C     1 
ATOM   3190 O  O     . ALA A 1 464 ? 100.963 99.252  97.721  1.00 20.33 ? 464 ALA A O     1 
ATOM   3191 C  CB    . ALA A 1 464 ? 98.757  98.963  100.017 1.00 20.33 ? 464 ALA A CB    1 
ATOM   3192 N  N     . ASP A 1 465 ? 99.278  100.705 97.332  1.00 26.69 ? 465 ASP A N     1 
ATOM   3193 C  CA    . ASP A 1 465 ? 100.099 101.744 96.724  1.00 26.69 ? 465 ASP A CA    1 
ATOM   3194 C  C     . ASP A 1 465 ? 99.898  103.019 97.527  1.00 26.69 ? 465 ASP A C     1 
ATOM   3195 O  O     . ASP A 1 465 ? 98.776  103.523 97.616  1.00 26.69 ? 465 ASP A O     1 
ATOM   3196 C  CB    . ASP A 1 465 ? 99.719  101.950 95.255  1.00 26.69 ? 465 ASP A CB    1 
ATOM   3197 C  CG    . ASP A 1 465 ? 100.685 102.850 94.519  1.00 26.69 ? 465 ASP A CG    1 
ATOM   3198 O  OD1   . ASP A 1 465 ? 101.887 102.523 94.464  1.00 26.69 ? 465 ASP A OD1   1 
ATOM   3199 O  OD2   . ASP A 1 465 ? 100.239 103.881 93.976  1.00 26.69 ? 465 ASP A OD2   1 
ATOM   3200 N  N     . LEU A 1 466 ? 100.978 103.538 98.109  1.00 24.96 ? 466 LEU A N     1 
ATOM   3201 C  CA    . LEU A 1 466 ? 100.909 104.664 99.033  1.00 24.96 ? 466 LEU A CA    1 
ATOM   3202 C  C     . LEU A 1 466 ? 101.339 105.944 98.325  1.00 24.96 ? 466 LEU A C     1 
ATOM   3203 O  O     . LEU A 1 466 ? 102.420 105.997 97.733  1.00 24.96 ? 466 LEU A O     1 
ATOM   3204 C  CB    . LEU A 1 466 ? 101.784 104.411 100.260 1.00 24.96 ? 466 LEU A CB    1 
ATOM   3205 C  CG    . LEU A 1 466 ? 101.717 103.011 100.871 1.00 24.96 ? 466 LEU A CG    1 
ATOM   3206 C  CD1   . LEU A 1 466 ? 102.927 102.746 101.745 1.00 24.96 ? 466 LEU A CD1   1 
ATOM   3207 C  CD2   . LEU A 1 466 ? 100.443 102.848 101.671 1.00 24.96 ? 466 LEU A CD2   1 
ATOM   3208 N  N     . ASN A 1 467 ? 100.496 106.972 98.405  1.00 26.56 ? 467 ASN A N     1 
ATOM   3209 C  CA    . ASN A 1 467 ? 100.709 108.236 97.714  1.00 26.56 ? 467 ASN A CA    1 
ATOM   3210 C  C     . ASN A 1 467 ? 100.142 109.351 98.583  1.00 26.56 ? 467 ASN A C     1 
ATOM   3211 O  O     . ASN A 1 467 ? 99.347  109.103 99.490  1.00 26.56 ? 467 ASN A O     1 
ATOM   3212 C  CB    . ASN A 1 467 ? 100.032 108.236 96.340  1.00 26.56 ? 467 ASN A CB    1 
ATOM   3213 C  CG    . ASN A 1 467 ? 100.638 107.230 95.383  1.00 26.56 ? 467 ASN A CG    1 
ATOM   3214 O  OD1   . ASN A 1 467 ? 101.855 107.100 95.282  1.00 26.56 ? 467 ASN A OD1   1 
ATOM   3215 N  ND2   . ASN A 1 467 ? 99.782  106.502 94.678  1.00 26.56 ? 467 ASN A ND2   1 
ATOM   3216 N  N     . LEU A 1 468 ? 100.551 110.592 98.304  1.00 25.20 ? 468 LEU A N     1 
ATOM   3217 C  CA    . LEU A 1 468 ? 99.970  111.723 99.027  1.00 25.20 ? 468 LEU A CA    1 
ATOM   3218 C  C     . LEU A 1 468 ? 98.485  111.863 98.724  1.00 25.20 ? 468 LEU A C     1 
ATOM   3219 O  O     . LEU A 1 468 ? 97.662  111.998 99.637  1.00 25.20 ? 468 LEU A O     1 
ATOM   3220 C  CB    . LEU A 1 468 ? 100.700 113.022 98.690  1.00 25.20 ? 468 LEU A CB    1 
ATOM   3221 C  CG    . LEU A 1 468 ? 101.931 113.387 99.515  1.00 25.20 ? 468 LEU A CG    1 
ATOM   3222 C  CD1   . LEU A 1 468 ? 102.472 114.723 99.054  1.00 25.20 ? 468 LEU A CD1   1 
ATOM   3223 C  CD2   . LEU A 1 468 ? 101.589 113.434 100.990 1.00 25.20 ? 468 LEU A CD2   1 
ATOM   3224 N  N     . SER A 1 469 ? 98.125  111.853 97.447  1.00 29.68 ? 469 SER A N     1 
ATOM   3225 C  CA    . SER A 1 469 ? 96.730  111.800 97.041  1.00 29.68 ? 469 SER A CA    1 
ATOM   3226 C  C     . SER A 1 469 ? 96.327  110.346 96.854  1.00 29.68 ? 469 SER A C     1 
ATOM   3227 O  O     . SER A 1 469 ? 97.088  109.550 96.296  1.00 29.68 ? 469 SER A O     1 
ATOM   3228 C  CB    . SER A 1 469 ? 96.510  112.587 95.751  1.00 29.68 ? 469 SER A CB    1 
ATOM   3229 O  OG    . SER A 1 469 ? 97.345  112.102 94.716  1.00 29.68 ? 469 SER A OG    1 
ATOM   3230 N  N     . ASN A 1 470 ? 95.126  110.001 97.326  1.00 29.12 ? 470 ASN A N     1 
ATOM   3231 C  CA    . ASN A 1 470 ? 94.668  108.613 97.382  1.00 29.12 ? 470 ASN A CA    1 
ATOM   3232 C  C     . ASN A 1 470 ? 95.639  107.775 98.221  1.00 29.12 ? 470 ASN A C     1 
ATOM   3233 O  O     . ASN A 1 470 ? 96.371  106.918 97.726  1.00 29.12 ? 470 ASN A O     1 
ATOM   3234 C  CB    . ASN A 1 470 ? 94.479  108.036 95.975  1.00 29.12 ? 470 ASN A CB    1 
ATOM   3235 C  CG    . ASN A 1 470 ? 93.620  108.921 95.099  1.00 29.12 ? 470 ASN A CG    1 
ATOM   3236 O  OD1   . ASN A 1 470 ? 92.464  109.191 95.417  1.00 29.12 ? 470 ASN A OD1   1 
ATOM   3237 N  ND2   . ASN A 1 470 ? 94.183  109.382 93.990  1.00 29.12 ? 470 ASN A ND2   1 
ATOM   3238 N  N     . ILE A 1 471 ? 95.631  108.100 99.518  1.00 24.72 ? 471 ILE A N     1 
ATOM   3239 C  CA    . ILE A 1 471 ? 96.607  107.585 100.479 1.00 24.72 ? 471 ILE A CA    1 
ATOM   3240 C  C     . ILE A 1 471 ? 96.861  106.092 100.301 1.00 24.72 ? 471 ILE A C     1 
ATOM   3241 O  O     . ILE A 1 471 ? 98.014  105.646 100.301 1.00 24.72 ? 471 ILE A O     1 
ATOM   3242 C  CB    . ILE A 1 471 ? 96.156  107.929 101.915 1.00 24.72 ? 471 ILE A CB    1 
ATOM   3243 C  CG1   . ILE A 1 471 ? 97.218  107.518 102.931 1.00 24.72 ? 471 ILE A CG1   1 
ATOM   3244 C  CG2   . ILE A 1 471 ? 94.780  107.346 102.237 1.00 24.72 ? 471 ILE A CG2   1 
ATOM   3245 C  CD1   . ILE A 1 471 ? 98.478  108.275 102.806 1.00 24.72 ? 471 ILE A CD1   1 
ATOM   3246 N  N     . VAL A 1 472 ? 95.807  105.295 100.150 1.00 24.54 ? 472 VAL A N     1 
ATOM   3247 C  CA    . VAL A 1 472 ? 95.939  103.854 99.975  1.00 24.54 ? 472 VAL A CA    1 
ATOM   3248 C  C     . VAL A 1 472 ? 95.018  103.421 98.844  1.00 24.54 ? 472 VAL A C     1 
ATOM   3249 O  O     . VAL A 1 472 ? 93.832  103.767 98.837  1.00 24.54 ? 472 VAL A O     1 
ATOM   3250 C  CB    . VAL A 1 472 ? 95.613  103.078 101.266 1.00 24.54 ? 472 VAL A CB    1 
ATOM   3251 C  CG1   . VAL A 1 472 ? 95.760  101.588 101.040 1.00 24.54 ? 472 VAL A CG1   1 
ATOM   3252 C  CG2   . VAL A 1 472 ? 96.509  103.520 102.403 1.00 24.54 ? 472 VAL A CG2   1 
ATOM   3253 N  N     . ALA A 1 473 ? 95.563  102.667 97.894  1.00 25.82 ? 473 ALA A N     1 
ATOM   3254 C  CA    . ALA A 1 473 ? 94.785  102.079 96.804  1.00 25.82 ? 473 ALA A CA    1 
ATOM   3255 C  C     . ALA A 1 473 ? 94.912  100.567 96.895  1.00 25.82 ? 473 ALA A C     1 
ATOM   3256 O  O     . ALA A 1 473 ? 95.861  99.987  96.339  1.00 25.82 ? 473 ALA A O     1 
ATOM   3257 C  CB    . ALA A 1 473 ? 95.270  102.581 95.447  1.00 25.82 ? 473 ALA A CB    1 
ATOM   3258 N  N     . PRO A 1 474 ? 93.996  99.886  97.577  1.00 25.64 ? 474 PRO A N     1 
ATOM   3259 C  CA    . PRO A 1 474 ? 94.180  98.464  97.869  1.00 25.64 ? 474 PRO A CA    1 
ATOM   3260 C  C     . PRO A 1 474 ? 93.575  97.536  96.828  1.00 25.64 ? 474 PRO A C     1 
ATOM   3261 O  O     . PRO A 1 474 ? 92.675  97.895  96.067  1.00 25.64 ? 474 PRO A O     1 
ATOM   3262 C  CB    . PRO A 1 474 ? 93.462  98.311  99.214  1.00 25.64 ? 474 PRO A CB    1 
ATOM   3263 C  CG    . PRO A 1 474 ? 92.363  99.316  99.156  1.00 25.64 ? 474 PRO A CG    1 
ATOM   3264 C  CD    . PRO A 1 474 ? 92.786  100.423 98.222  1.00 25.64 ? 474 PRO A CD    1 
ATOM   3265 N  N     . VAL A 1 475 ? 94.100  96.313  96.808  1.00 25.06 ? 475 VAL A N     1 
ATOM   3266 C  CA    . VAL A 1 475 ? 93.628  95.247  95.933  1.00 25.06 ? 475 VAL A CA    1 
ATOM   3267 C  C     . VAL A 1 475 ? 93.574  93.965  96.748  1.00 25.06 ? 475 VAL A C     1 
ATOM   3268 O  O     . VAL A 1 475 ? 94.508  93.667  97.495  1.00 25.06 ? 475 VAL A O     1 
ATOM   3269 C  CB    . VAL A 1 475 ? 94.543  95.063  94.705  1.00 25.06 ? 475 VAL A CB    1 
ATOM   3270 C  CG1   . VAL A 1 475 ? 94.250  93.749  94.007  1.00 25.06 ? 475 VAL A CG1   1 
ATOM   3271 C  CG2   . VAL A 1 475 ? 94.371  96.215  93.743  1.00 25.06 ? 475 VAL A CG2   1 
ATOM   3272 N  N     . LYS A 1 476 ? 92.488  93.212  96.615  1.00 28.19 ? 476 LYS A N     1 
ATOM   3273 C  CA    . LYS A 1 476 ? 92.341  91.930  97.286  1.00 28.19 ? 476 LYS A CA    1 
ATOM   3274 C  C     . LYS A 1 476 ? 92.200  90.825  96.251  1.00 28.19 ? 476 LYS A C     1 
ATOM   3275 O  O     . LYS A 1 476 ? 91.503  90.992  95.248  1.00 28.19 ? 476 LYS A O     1 
ATOM   3276 C  CB    . LYS A 1 476 ? 91.127  91.934  98.215  1.00 28.19 ? 476 LYS A CB    1 
ATOM   3277 C  CG    . LYS A 1 476 ? 91.464  92.022  99.694  1.00 28.19 ? 476 LYS A CG    1 
ATOM   3278 C  CD    . LYS A 1 476 ? 90.202  91.948  100.532 1.00 28.19 ? 476 LYS A CD    1 
ATOM   3279 C  CE    . LYS A 1 476 ? 90.490  92.175  102.001 1.00 28.19 ? 476 LYS A CE    1 
ATOM   3280 N  NZ    . LYS A 1 476 ? 89.236  92.344  102.781 1.00 28.19 ? 476 LYS A NZ    1 
ATOM   3281 N  N     . ALA A 1 477 ? 92.862  89.697  96.494  1.00 27.86 ? 477 ALA A N     1 
ATOM   3282 C  CA    . ALA A 1 477 ? 92.826  88.592  95.550  1.00 27.86 ? 477 ALA A CA    1 
ATOM   3283 C  C     . ALA A 1 477 ? 92.894  87.272  96.300  1.00 27.86 ? 477 ALA A C     1 
ATOM   3284 O  O     . ALA A 1 477 ? 93.456  87.182  97.393  1.00 27.86 ? 477 ALA A O     1 
ATOM   3285 C  CB    . ALA A 1 477 ? 93.970  88.681  94.537  1.00 27.86 ? 477 ALA A CB    1 
ATOM   3286 N  N     . ARG A 1 478 ? 92.319  86.242  95.688  1.00 34.83 ? 478 ARG A N     1 
ATOM   3287 C  CA    . ARG A 1 478 ? 92.305  84.893  96.235  1.00 34.83 ? 478 ARG A CA    1 
ATOM   3288 C  C     . ARG A 1 478 ? 93.064  83.967  95.296  1.00 34.83 ? 478 ARG A C     1 
ATOM   3289 O  O     . ARG A 1 478 ? 92.733  83.879  94.112  1.00 34.83 ? 478 ARG A O     1 
ATOM   3290 C  CB    . ARG A 1 478 ? 90.869  84.401  96.424  1.00 34.83 ? 478 ARG A CB    1 
ATOM   3291 C  CG    . ARG A 1 478 ? 90.748  82.925  96.724  1.00 34.83 ? 478 ARG A CG    1 
ATOM   3292 C  CD    . ARG A 1 478 ? 89.315  82.547  97.068  1.00 34.83 ? 478 ARG A CD    1 
ATOM   3293 N  NE    . ARG A 1 478 ? 89.014  82.800  98.471  1.00 34.83 ? 478 ARG A NE    1 
ATOM   3294 C  CZ    . ARG A 1 478 ? 88.064  83.621  98.897  1.00 34.83 ? 478 ARG A CZ    1 
ATOM   3295 N  NH1   . ARG A 1 478 ? 87.278  84.266  98.052  1.00 34.83 ? 478 ARG A NH1   1 
ATOM   3296 N  NH2   . ARG A 1 478 ? 87.900  83.800  100.205 1.00 34.83 ? 478 ARG A NH2   1 
ATOM   3297 N  N     . ILE A 1 479 ? 94.072  83.273  95.824  1.00 34.37 ? 479 ILE A N     1 
ATOM   3298 C  CA    . ILE A 1 479 ? 94.933  82.419  95.019  1.00 34.37 ? 479 ILE A CA    1 
ATOM   3299 C  C     . ILE A 1 479 ? 94.967  81.029  95.633  1.00 34.37 ? 479 ILE A C     1 
ATOM   3300 O  O     . ILE A 1 479 ? 94.684  80.839  96.817  1.00 34.37 ? 479 ILE A O     1 
ATOM   3301 C  CB    . ILE A 1 479 ? 96.367  82.977  94.895  1.00 34.37 ? 479 ILE A CB    1 
ATOM   3302 C  CG1   . ILE A 1 479 ? 97.077  82.938  96.248  1.00 34.37 ? 479 ILE A CG1   1 
ATOM   3303 C  CG2   . ILE A 1 479 ? 96.346  84.390  94.343  1.00 34.37 ? 479 ILE A CG2   1 
ATOM   3304 C  CD1   . ILE A 1 479 ? 98.556  83.222  96.168  1.00 34.37 ? 479 ILE A CD1   1 
ATOM   3305 N  N     . GLY A 1 480 ? 95.319  80.049  94.807  1.00 33.93 ? 480 GLY A N     1 
ATOM   3306 C  CA    . GLY A 1 480 ? 95.435  78.687  95.284  1.00 33.93 ? 480 GLY A CA    1 
ATOM   3307 C  C     . GLY A 1 480 ? 95.807  77.677  94.220  1.00 33.93 ? 480 GLY A C     1 
ATOM   3308 O  O     . GLY A 1 480 ? 95.349  77.771  93.080  1.00 33.93 ? 480 GLY A O     1 
ATOM   3309 N  N     . LYS A 1 481 ? 96.643  76.707  94.582  1.00 40.10 ? 481 LYS A N     1 
ATOM   3310 C  CA    . LYS A 1 481 ? 96.954  75.615  93.670  1.00 40.10 ? 481 LYS A CA    1 
ATOM   3311 C  C     . LYS A 1 481 ? 95.713  74.768  93.421  1.00 40.10 ? 481 LYS A C     1 
ATOM   3312 O  O     . LYS A 1 481 ? 94.911  74.537  94.330  1.00 40.10 ? 481 LYS A O     1 
ATOM   3313 C  CB    . LYS A 1 481 ? 98.083  74.752  94.234  1.00 40.10 ? 481 LYS A CB    1 
ATOM   3314 C  CG    . LYS A 1 481 ? 98.478  73.603  93.320  1.00 40.10 ? 481 LYS A CG    1 
ATOM   3315 C  CD    . LYS A 1 481 ? 99.156  74.121  92.064  1.00 40.10 ? 481 LYS A CD    1 
ATOM   3316 C  CE    . LYS A 1 481 ? 99.657  72.994  91.181  1.00 40.10 ? 481 LYS A CE    1 
ATOM   3317 N  NZ    . LYS A 1 481 ? 100.258 73.521  89.925  1.00 40.10 ? 481 LYS A NZ    1 
ATOM   3318 N  N     . GLY A 1 482 ? 95.559  74.303  92.186  1.00 41.89 ? 482 GLY A N     1 
ATOM   3319 C  CA    . GLY A 1 482 ? 94.360  73.590  91.807  1.00 41.89 ? 482 GLY A CA    1 
ATOM   3320 C  C     . GLY A 1 482 ? 93.179  74.477  91.504  1.00 41.89 ? 482 GLY A C     1 
ATOM   3321 O  O     . GLY A 1 482 ? 92.052  73.976  91.410  1.00 41.89 ? 482 GLY A O     1 
ATOM   3322 N  N     . LEU A 1 483 ? 93.400  75.776  91.352  1.00 41.84 ? 483 LEU A N     1 
ATOM   3323 C  CA    . LEU A 1 483 ? 92.347  76.745  91.101  1.00 41.84 ? 483 LEU A CA    1 
ATOM   3324 C  C     . LEU A 1 483 ? 92.693  77.560  89.861  1.00 41.84 ? 483 LEU A C     1 
ATOM   3325 O  O     . LEU A 1 483 ? 93.866  77.802  89.565  1.00 41.84 ? 483 LEU A O     1 
ATOM   3326 C  CB    . LEU A 1 483 ? 92.162  77.648  92.325  1.00 41.84 ? 483 LEU A CB    1 
ATOM   3327 C  CG    . LEU A 1 483 ? 91.011  78.644  92.406  1.00 41.84 ? 483 LEU A CG    1 
ATOM   3328 C  CD1   . LEU A 1 483 ? 90.662  78.898  93.858  1.00 41.84 ? 483 LEU A CD1   1 
ATOM   3329 C  CD2   . LEU A 1 483 ? 91.417  79.935  91.755  1.00 41.84 ? 483 LEU A CD2   1 
ATOM   3330 N  N     . GLU A 1 484 ? 91.662  77.978  89.133  1.00 46.03 ? 484 GLU A N     1 
ATOM   3331 C  CA    . GLU A 1 484 ? 91.826  78.678  87.867  1.00 46.03 ? 484 GLU A CA    1 
ATOM   3332 C  C     . GLU A 1 484 ? 91.370  80.125  87.991  1.00 46.03 ? 484 GLU A C     1 
ATOM   3333 O  O     . GLU A 1 484 ? 90.375  80.419  88.659  1.00 46.03 ? 484 GLU A O     1 
ATOM   3334 C  CB    . GLU A 1 484 ? 91.042  77.984  86.750  1.00 46.03 ? 484 GLU A CB    1 
ATOM   3335 C  CG    . GLU A 1 484 ? 91.548  76.593  86.409  1.00 46.03 ? 484 GLU A CG    1 
ATOM   3336 C  CD    . GLU A 1 484 ? 92.803  76.621  85.558  1.00 46.03 ? 484 GLU A CD    1 
ATOM   3337 O  OE1   . GLU A 1 484 ? 93.176  77.712  85.077  1.00 46.03 ? 484 GLU A OE1   1 
ATOM   3338 O  OE2   . GLU A 1 484 ? 93.418  75.550  85.370  1.00 46.03 ? 484 GLU A OE2   1 
ATOM   3339 N  N     . GLY A 1 485 ? 92.104  81.023  87.340  1.00 36.75 ? 485 GLY A N     1 
ATOM   3340 C  CA    . GLY A 1 485 ? 91.774  82.427  87.338  1.00 36.75 ? 485 GLY A CA    1 
ATOM   3341 C  C     . GLY A 1 485 ? 92.704  83.222  86.446  1.00 36.75 ? 485 GLY A C     1 
ATOM   3342 O  O     . GLY A 1 485 ? 93.718  82.714  85.959  1.00 36.75 ? 485 GLY A O     1 
ATOM   3343 N  N     . PRO A 1 486 ? 92.365  84.490  86.202  1.00 34.56 ? 486 PRO A N     1 
ATOM   3344 C  CA    . PRO A 1 486 ? 93.217  85.312  85.327  1.00 34.56 ? 486 PRO A CA    1 
ATOM   3345 C  C     . PRO A 1 486 ? 94.637  85.496  85.837  1.00 34.56 ? 486 PRO A C     1 
ATOM   3346 O  O     . PRO A 1 486 ? 95.576  85.512  85.033  1.00 34.56 ? 486 PRO A O     1 
ATOM   3347 C  CB    . PRO A 1 486 ? 92.459  86.646  85.255  1.00 34.56 ? 486 PRO A CB    1 
ATOM   3348 C  CG    . PRO A 1 486 ? 91.497  86.622  86.387  1.00 34.56 ? 486 PRO A CG    1 
ATOM   3349 C  CD    . PRO A 1 486 ? 91.142  85.195  86.609  1.00 34.56 ? 486 PRO A CD    1 
ATOM   3350 N  N     . LEU A 1 487 ? 94.829  85.622  87.146  1.00 33.05 ? 487 LEU A N     1 
ATOM   3351 C  CA    . LEU A 1 487 ? 96.148  85.936  87.675  1.00 33.05 ? 487 LEU A CA    1 
ATOM   3352 C  C     . LEU A 1 487 ? 97.049  84.706  87.665  1.00 33.05 ? 487 LEU A C     1 
ATOM   3353 O  O     . LEU A 1 487 ? 96.601  83.574  87.480  1.00 33.05 ? 487 LEU A O     1 
ATOM   3354 C  CB    . LEU A 1 487 ? 96.047  86.488  89.095  1.00 33.05 ? 487 LEU A CB    1 
ATOM   3355 C  CG    . LEU A 1 487 ? 95.748  87.976  89.258  1.00 33.05 ? 487 LEU A CG    1 
ATOM   3356 C  CD1   . LEU A 1 487 ? 94.291  88.266  88.991  1.00 33.05 ? 487 LEU A CD1   1 
ATOM   3357 C  CD2   . LEU A 1 487 ? 96.124  88.418  90.649  1.00 33.05 ? 487 LEU A CD2   1 
ATOM   3358 N  N     . HIS A 1 488 ? 98.343  84.947  87.865  1.00 30.82 ? 488 HIS A N     1 
ATOM   3359 C  CA    . HIS A 1 488 ? 99.345  83.893  87.896  1.00 30.82 ? 488 HIS A CA    1 
ATOM   3360 C  C     . HIS A 1 488 ? 100.297 84.126  89.058  1.00 30.82 ? 488 HIS A C     1 
ATOM   3361 O  O     . HIS A 1 488 ? 100.793 85.239  89.251  1.00 30.82 ? 488 HIS A O     1 
ATOM   3362 C  CB    . HIS A 1 488 ? 100.125 83.834  86.578  1.00 30.82 ? 488 HIS A CB    1 
ATOM   3363 C  CG    . HIS A 1 488 ? 101.156 82.750  86.530  1.00 30.82 ? 488 HIS A CG    1 
ATOM   3364 N  ND1   . HIS A 1 488 ? 102.503 83.009  86.410  1.00 30.82 ? 488 HIS A ND1   1 
ATOM   3365 C  CD2   . HIS A 1 488 ? 101.037 81.403  86.586  1.00 30.82 ? 488 HIS A CD2   1 
ATOM   3366 C  CE1   . HIS A 1 488 ? 103.170 81.869  86.394  1.00 30.82 ? 488 HIS A CE1   1 
ATOM   3367 N  NE2   . HIS A 1 488 ? 102.303 80.879  86.500  1.00 30.82 ? 488 HIS A NE2   1 
ATOM   3368 N  N     . ALA A 1 489 ? 100.547 83.071  89.830  1.00 31.88 ? 489 ALA A N     1 
ATOM   3369 C  CA    . ALA A 1 489 ? 101.482 83.103  90.947  1.00 31.88 ? 489 ALA A CA    1 
ATOM   3370 C  C     . ALA A 1 489 ? 102.612 82.129  90.658  1.00 31.88 ? 489 ALA A C     1 
ATOM   3371 O  O     . ALA A 1 489 ? 102.364 80.952  90.380  1.00 31.88 ? 489 ALA A O     1 
ATOM   3372 C  CB    . ALA A 1 489 ? 100.788 82.747  92.263  1.00 31.88 ? 489 ALA A CB    1 
ATOM   3373 N  N     . LEU A 1 490 ? 103.845 82.616  90.734  1.00 32.05 ? 490 LEU A N     1 
ATOM   3374 C  CA    . LEU A 1 490 ? 105.001 81.805  90.382  1.00 32.05 ? 490 LEU A CA    1 
ATOM   3375 C  C     . LEU A 1 490 ? 105.129 80.612  91.319  1.00 32.05 ? 490 LEU A C     1 
ATOM   3376 O  O     . LEU A 1 490 ? 105.087 80.764  92.543  1.00 32.05 ? 490 LEU A O     1 
ATOM   3377 C  CB    . LEU A 1 490 ? 106.264 82.657  90.441  1.00 32.05 ? 490 LEU A CB    1 
ATOM   3378 C  CG    . LEU A 1 490 ? 107.576 82.049  89.959  1.00 32.05 ? 490 LEU A CG    1 
ATOM   3379 C  CD1   . LEU A 1 490 ? 107.549 81.795  88.462  1.00 32.05 ? 490 LEU A CD1   1 
ATOM   3380 C  CD2   . LEU A 1 490 ? 108.705 82.975  90.334  1.00 32.05 ? 490 LEU A CD2   1 
ATOM   3381 N  N     . ASP A 1 491 ? 105.284 79.423  90.739  1.00 34.27 ? 491 ASP A N     1 
ATOM   3382 C  CA    . ASP A 1 491 ? 105.460 78.158  91.448  1.00 34.27 ? 491 ASP A CA    1 
ATOM   3383 C  C     . ASP A 1 491 ? 104.288 77.805  92.356  1.00 34.27 ? 491 ASP A C     1 
ATOM   3384 O  O     . ASP A 1 491 ? 104.415 76.907  93.194  1.00 34.27 ? 491 ASP A O     1 
ATOM   3385 C  CB    . ASP A 1 491 ? 106.758 78.143  92.267  1.00 34.27 ? 491 ASP A CB    1 
ATOM   3386 C  CG    . ASP A 1 491 ? 108.000 78.121  91.398  1.00 34.27 ? 491 ASP A CG    1 
ATOM   3387 O  OD1   . ASP A 1 491 ? 107.931 77.583  90.274  1.00 34.27 ? 491 ASP A OD1   1 
ATOM   3388 O  OD2   . ASP A 1 491 ? 109.049 78.630  91.845  1.00 34.27 ? 491 ASP A OD2   1 
ATOM   3389 N  N     . TYR A 1 492 ? 103.161 78.479  92.227  1.00 35.02 ? 492 TYR A N     1 
ATOM   3390 C  CA    . TYR A 1 492 ? 102.061 78.189  93.140  1.00 35.02 ? 492 TYR A CA    1 
ATOM   3391 C  C     . TYR A 1 492 ? 100.736 77.925  92.441  1.00 35.02 ? 492 TYR A C     1 
ATOM   3392 O  O     . TYR A 1 492 ? 99.998  77.037  92.865  1.00 35.02 ? 492 TYR A O     1 
ATOM   3393 C  CB    . TYR A 1 492 ? 101.895 79.346  94.133  1.00 35.02 ? 492 TYR A CB    1 
ATOM   3394 C  CG    . TYR A 1 492 ? 100.855 79.088  95.195  1.00 35.02 ? 492 TYR A CG    1 
ATOM   3395 C  CD1   . TYR A 1 492 ? 100.978 78.016  96.067  1.00 35.02 ? 492 TYR A CD1   1 
ATOM   3396 C  CD2   . TYR A 1 492 ? 99.746  79.911  95.321  1.00 35.02 ? 492 TYR A CD2   1 
ATOM   3397 C  CE1   . TYR A 1 492 ? 100.031 77.775  97.035  1.00 35.02 ? 492 TYR A CE1   1 
ATOM   3398 C  CE2   . TYR A 1 492 ? 98.795  79.676  96.286  1.00 35.02 ? 492 TYR A CE2   1 
ATOM   3399 C  CZ    . TYR A 1 492 ? 98.942  78.609  97.139  1.00 35.02 ? 492 TYR A CZ    1 
ATOM   3400 O  OH    . TYR A 1 492 ? 97.993  78.373  98.104  1.00 35.02 ? 492 TYR A OH    1 
ATOM   3401 N  N     . GLY A 1 493 ? 100.413 78.668  91.395  1.00 30.95 ? 493 GLY A N     1 
ATOM   3402 C  CA    . GLY A 1 493 ? 99.147  78.504  90.721  1.00 30.95 ? 493 GLY A CA    1 
ATOM   3403 C  C     . GLY A 1 493 ? 98.565  79.845  90.337  1.00 30.95 ? 493 GLY A C     1 
ATOM   3404 O  O     . GLY A 1 493 ? 99.282  80.831  90.198  1.00 30.95 ? 493 GLY A O     1 
ATOM   3405 N  N     . TYR A 1 494 ? 97.250  79.873  90.167  1.00 34.36 ? 494 TYR A N     1 
ATOM   3406 C  CA    . TYR A 1 494 ? 96.548  81.039  89.662  1.00 34.36 ? 494 TYR A CA    1 
ATOM   3407 C  C     . TYR A 1 494 ? 95.703  81.671  90.765  1.00 34.36 ? 494 TYR A C     1 
ATOM   3408 O  O     . TYR A 1 494 ? 95.746  81.260  91.927  1.00 34.36 ? 494 TYR A O     1 
ATOM   3409 C  CB    . TYR A 1 494 ? 95.691  80.657  88.451  1.00 34.36 ? 494 TYR A CB    1 
ATOM   3410 C  CG    . TYR A 1 494 ? 96.445  79.946  87.350  1.00 34.36 ? 494 TYR A CG    1 
ATOM   3411 C  CD1   . TYR A 1 494 ? 96.805  80.616  86.191  1.00 34.36 ? 494 TYR A CD1   1 
ATOM   3412 C  CD2   . TYR A 1 494 ? 96.772  78.602  87.457  1.00 34.36 ? 494 TYR A CD2   1 
ATOM   3413 C  CE1   . TYR A 1 494 ? 97.488  79.975  85.182  1.00 34.36 ? 494 TYR A CE1   1 
ATOM   3414 C  CE2   . TYR A 1 494 ? 97.455  77.953  86.454  1.00 34.36 ? 494 TYR A CE2   1 
ATOM   3415 C  CZ    . TYR A 1 494 ? 97.810  78.642  85.318  1.00 34.36 ? 494 TYR A CZ    1 
ATOM   3416 O  OH    . TYR A 1 494 ? 98.489  77.994  84.313  1.00 34.36 ? 494 TYR A OH    1 
ATOM   3417 N  N     . GLY A 1 495 ? 94.926  82.686  90.401  1.00 33.25 ? 495 GLY A N     1 
ATOM   3418 C  CA    . GLY A 1 495 ? 94.050  83.342  91.354  1.00 33.25 ? 495 GLY A CA    1 
ATOM   3419 C  C     . GLY A 1 495 ? 93.161  84.347  90.658  1.00 33.25 ? 495 GLY A C     1 
ATOM   3420 O  O     . GLY A 1 495 ? 93.326  84.641  89.472  1.00 33.25 ? 495 GLY A O     1 
ATOM   3421 N  N     . GLU A 1 496 ? 92.203  84.871  91.420  1.00 34.23 ? 496 GLU A N     1 
ATOM   3422 C  CA    . GLU A 1 496 ? 91.278  85.877  90.917  1.00 34.23 ? 496 GLU A CA    1 
ATOM   3423 C  C     . GLU A 1 496 ? 91.079  86.951  91.974  1.00 34.23 ? 496 GLU A C     1 
ATOM   3424 O  O     . GLU A 1 496 ? 91.483  86.801  93.128  1.00 34.23 ? 496 GLU A O     1 
ATOM   3425 C  CB    . GLU A 1 496 ? 89.916  85.282  90.529  1.00 34.23 ? 496 GLU A CB    1 
ATOM   3426 C  CG    . GLU A 1 496 ? 89.210  84.532  91.644  1.00 34.23 ? 496 GLU A CG    1 
ATOM   3427 C  CD    . GLU A 1 496 ? 89.771  83.146  91.843  1.00 34.23 ? 496 GLU A CD    1 
ATOM   3428 O  OE1   . GLU A 1 496 ? 90.626  82.749  91.029  1.00 34.23 ? 496 GLU A OE1   1 
ATOM   3429 O  OE2   . GLU A 1 496 ? 89.368  82.460  92.806  1.00 34.23 ? 496 GLU A OE2   1 
ATOM   3430 N  N     . LEU A 1 497 ? 90.444  88.042  91.561  1.00 30.71 ? 497 LEU A N     1 
ATOM   3431 C  CA    . LEU A 1 497 ? 90.243  89.179  92.443  1.00 30.71 ? 497 LEU A CA    1 
ATOM   3432 C  C     . LEU A 1 497 ? 89.033  88.965  93.345  1.00 30.71 ? 497 LEU A C     1 
ATOM   3433 O  O     . LEU A 1 497 ? 87.977  88.510  92.897  1.00 30.71 ? 497 LEU A O     1 
ATOM   3434 C  CB    . LEU A 1 497 ? 90.066  90.456  91.625  1.00 30.71 ? 497 LEU A CB    1 
ATOM   3435 C  CG    . LEU A 1 497 ? 91.237  90.822  90.714  1.00 30.71 ? 497 LEU A CG    1 
ATOM   3436 C  CD1   . LEU A 1 497 ? 90.946  92.108  89.970  1.00 30.71 ? 497 LEU A CD1   1 
ATOM   3437 C  CD2   . LEU A 1 497 ? 92.526  90.935  91.501  1.00 30.71 ? 497 LEU A CD2   1 
ATOM   3438 N  N     . ILE A 1 498 ? 89.197  89.297  94.626  1.00 31.55 ? 498 ILE A N     1 
ATOM   3439 C  CA    . ILE A 1 498 ? 88.102  89.274  95.590  1.00 31.55 ? 498 ILE A CA    1 
ATOM   3440 C  C     . ILE A 1 498 ? 87.462  90.653  95.623  1.00 31.55 ? 498 ILE A C     1 
ATOM   3441 O  O     . ILE A 1 498 ? 86.293  90.819  95.262  1.00 31.55 ? 498 ILE A O     1 
ATOM   3442 C  CB    . ILE A 1 498 ? 88.590  88.874  96.992  1.00 31.55 ? 498 ILE A CB    1 
ATOM   3443 C  CG1   . ILE A 1 498 ? 88.940  87.393  97.045  1.00 31.55 ? 498 ILE A CG1   1 
ATOM   3444 C  CG2   . ILE A 1 498 ? 87.534  89.189  98.030  1.00 31.55 ? 498 ILE A CG2   1 
ATOM   3445 C  CD1   . ILE A 1 498 ? 89.315  86.931  98.428  1.00 31.55 ? 498 ILE A CD1   1 
ATOM   3446 N  N     . ASP A 1 499 ? 88.229  91.648  96.053  1.00 31.34 ? 499 ASP A N     1 
ATOM   3447 C  CA    . ASP A 1 499 ? 87.797  93.038  96.044  1.00 31.34 ? 499 ASP A CA    1 
ATOM   3448 C  C     . ASP A 1 499 ? 88.602  93.771  94.981  1.00 31.34 ? 499 ASP A C     1 
ATOM   3449 O  O     . ASP A 1 499 ? 89.829  93.867  95.083  1.00 31.34 ? 499 ASP A O     1 
ATOM   3450 C  CB    . ASP A 1 499 ? 87.988  93.681  97.417  1.00 31.34 ? 499 ASP A CB    1 
ATOM   3451 C  CG    . ASP A 1 499 ? 87.073  94.870  97.636  1.00 31.34 ? 499 ASP A CG    1 
ATOM   3452 O  OD1   . ASP A 1 499 ? 87.177  95.516  98.699  1.00 31.34 ? 499 ASP A OD1   1 
ATOM   3453 O  OD2   . ASP A 1 499 ? 86.248  95.159  96.744  1.00 31.34 ? 499 ASP A OD2   1 
ATOM   3454 N  N     . GLY A 1 500 ? 87.912  94.284  93.969  1.00 30.91 ? 500 GLY A N     1 
ATOM   3455 C  CA    . GLY A 1 500 ? 88.561  94.854  92.815  1.00 30.91 ? 500 GLY A CA    1 
ATOM   3456 C  C     . GLY A 1 500 ? 89.424  96.043  93.166  1.00 30.91 ? 500 GLY A C     1 
ATOM   3457 O  O     . GLY A 1 500 ? 89.254  96.671  94.215  1.00 30.91 ? 500 GLY A O     1 
ATOM   3458 N  N     . PRO A 1 501 ? 90.390  96.358  92.304  1.00 32.87 ? 501 PRO A N     1 
ATOM   3459 C  CA    . PRO A 1 501 ? 91.237  97.531  92.544  1.00 32.87 ? 501 PRO A CA    1 
ATOM   3460 C  C     . PRO A 1 501 ? 90.393  98.787  92.690  1.00 32.87 ? 501 PRO A C     1 
ATOM   3461 O  O     . PRO A 1 501 ? 89.463  99.025  91.917  1.00 32.87 ? 501 PRO A O     1 
ATOM   3462 C  CB    . PRO A 1 501 ? 92.127  97.584  91.298  1.00 32.87 ? 501 PRO A CB    1 
ATOM   3463 C  CG    . PRO A 1 501 ? 92.169  96.180  90.813  1.00 32.87 ? 501 PRO A CG    1 
ATOM   3464 C  CD    . PRO A 1 501 ? 90.821  95.596  91.120  1.00 32.87 ? 501 PRO A CD    1 
ATOM   3465 N  N     . LYS A 1 502 ? 90.725  99.589  93.694  1.00 32.38 ? 502 LYS A N     1 
ATOM   3466 C  CA    . LYS A 1 502 ? 89.923  100.751 94.043  1.00 32.38 ? 502 LYS A CA    1 
ATOM   3467 C  C     . LYS A 1 502 ? 90.754  101.657 94.942  1.00 32.38 ? 502 LYS A C     1 
ATOM   3468 O  O     . LYS A 1 502 ? 91.907  101.360 95.263  1.00 32.38 ? 502 LYS A O     1 
ATOM   3469 C  CB    . LYS A 1 502 ? 88.621  100.329 94.726  1.00 32.38 ? 502 LYS A CB    1 
ATOM   3470 C  CG    . LYS A 1 502 ? 88.834  99.680  96.080  1.00 32.38 ? 502 LYS A CG    1 
ATOM   3471 C  CD    . LYS A 1 502 ? 87.525  99.477  96.816  1.00 32.38 ? 502 LYS A CD    1 
ATOM   3472 C  CE    . LYS A 1 502 ? 87.775  98.991  98.229  1.00 32.38 ? 502 LYS A CE    1 
ATOM   3473 N  NZ    . LYS A 1 502 ? 88.886  98.002  98.269  1.00 32.38 ? 502 LYS A NZ    1 
ATOM   3474 N  N     . ILE A 1 503 ? 90.151  102.771 95.346  1.00 32.95 ? 503 ILE A N     1 
ATOM   3475 C  CA    . ILE A 1 503 ? 90.757  103.709 96.281  1.00 32.95 ? 503 ILE A CA    1 
ATOM   3476 C  C     . ILE A 1 503 ? 90.051  103.562 97.618  1.00 32.95 ? 503 ILE A C     1 
ATOM   3477 O  O     . ILE A 1 503 ? 88.818  103.630 97.689  1.00 32.95 ? 503 ILE A O     1 
ATOM   3478 C  CB    . ILE A 1 503 ? 90.672  105.154 95.763  1.00 32.95 ? 503 ILE A CB    1 
ATOM   3479 C  CG1   . ILE A 1 503 ? 91.373  105.282 94.410  1.00 32.95 ? 503 ILE A CG1   1 
ATOM   3480 C  CG2   . ILE A 1 503 ? 91.290  106.108 96.763  1.00 32.95 ? 503 ILE A CG2   1 
ATOM   3481 C  CD1   . ILE A 1 503 ? 90.441  105.220 93.226  1.00 32.95 ? 503 ILE A CD1   1 
ATOM   3482 N  N     . LEU A 1 504 ? 90.831  103.344 98.678  1.00 30.67 ? 504 LEU A N     1 
ATOM   3483 C  CA    . LEU A 1 504 ? 90.243  103.071 99.985  1.00 30.67 ? 504 LEU A CA    1 
ATOM   3484 C  C     . LEU A 1 504 ? 89.464  104.267 100.514 1.00 30.67 ? 504 LEU A C     1 
ATOM   3485 O  O     . LEU A 1 504 ? 88.351  104.112 101.027 1.00 30.67 ? 504 LEU A O     1 
ATOM   3486 C  CB    . LEU A 1 504 ? 91.335  102.660 100.969 1.00 30.67 ? 504 LEU A CB    1 
ATOM   3487 C  CG    . LEU A 1 504 ? 90.841  102.292 102.359 1.00 30.67 ? 504 LEU A CG    1 
ATOM   3488 C  CD1   . LEU A 1 504 ? 89.919  101.113 102.249 1.00 30.67 ? 504 LEU A CD1   1 
ATOM   3489 C  CD2   . LEU A 1 504 ? 92.016  101.953 103.251 1.00 30.67 ? 504 LEU A CD2   1 
ATOM   3490 N  N     . THR A 1 505 ? 90.023  105.466 100.392 1.00 34.92 ? 505 THR A N     1 
ATOM   3491 C  CA    . THR A 1 505 ? 89.354  106.659 100.889 1.00 34.92 ? 505 THR A CA    1 
ATOM   3492 C  C     . THR A 1 505 ? 89.774  107.877 100.076 1.00 34.92 ? 505 THR A C     1 
ATOM   3493 O  O     . THR A 1 505 ? 90.968  108.189 99.993  1.00 34.92 ? 505 THR A O     1 
ATOM   3494 C  CB    . THR A 1 505 ? 89.666  106.879 102.372 1.00 34.92 ? 505 THR A CB    1 
ATOM   3495 O  OG1   . THR A 1 505 ? 89.000  105.884 103.158 1.00 34.92 ? 505 THR A OG1   1 
ATOM   3496 C  CG2   . THR A 1 505 ? 89.200  108.252 102.816 1.00 34.92 ? 505 THR A CG2   1 
ATOM   3497 N  N     . PRO A 1 506 ? 88.830  108.585 99.466  1.00 38.58 ? 506 PRO A N     1 
ATOM   3498 C  CA    . PRO A 1 506 ? 89.178  109.799 98.722  1.00 38.58 ? 506 PRO A CA    1 
ATOM   3499 C  C     . PRO A 1 506 ? 89.646  110.903 99.659  1.00 38.58 ? 506 PRO A C     1 
ATOM   3500 O  O     . PRO A 1 506 ? 89.333  110.933 100.850 1.00 38.58 ? 506 PRO A O     1 
ATOM   3501 C  CB    . PRO A 1 506 ? 87.872  110.174 98.018  1.00 38.58 ? 506 PRO A CB    1 
ATOM   3502 C  CG    . PRO A 1 506 ? 86.805  109.568 98.862  1.00 38.58 ? 506 PRO A CG    1 
ATOM   3503 C  CD    . PRO A 1 506 ? 87.386  108.303 99.426  1.00 38.58 ? 506 PRO A CD    1 
ATOM   3504 N  N     . ASP A 1 507 ? 90.420  111.824 99.092  1.00 35.68 ? 507 ASP A N     1 
ATOM   3505 C  CA    . ASP A 1 507 ? 90.977  112.923 99.869  1.00 35.68 ? 507 ASP A CA    1 
ATOM   3506 C  C     . ASP A 1 507 ? 89.882  113.876 100.326 1.00 35.68 ? 507 ASP A C     1 
ATOM   3507 O  O     . ASP A 1 507 ? 88.881  114.079 99.634  1.00 35.68 ? 507 ASP A O     1 
ATOM   3508 C  CB    . ASP A 1 507 ? 92.016  113.677 99.043  1.00 35.68 ? 507 ASP A CB    1 
ATOM   3509 C  CG    . ASP A 1 507 ? 93.144  112.783 98.572  1.00 35.68 ? 507 ASP A CG    1 
ATOM   3510 O  OD1   . ASP A 1 507 ? 93.240  111.637 99.059  1.00 35.68 ? 507 ASP A OD1   1 
ATOM   3511 O  OD2   . ASP A 1 507 ? 93.932  113.228 97.713  1.00 35.68 ? 507 ASP A OD2   1 
ATOM   3512 N  N     . GLY A 1 508 ? 90.081  114.466 101.501 1.00 27.50 ? 508 GLY A N     1 
ATOM   3513 C  CA    . GLY A 1 508 ? 89.119  115.375 102.074 1.00 27.50 ? 508 GLY A CA    1 
ATOM   3514 C  C     . GLY A 1 508 ? 89.094  116.719 101.379 1.00 27.50 ? 508 GLY A C     1 
ATOM   3515 O  O     . GLY A 1 508 ? 89.952  117.035 100.550 1.00 27.50 ? 508 GLY A O     1 
ATOM   3516 N  N     . PRO A 1 509 ? 88.089  117.535 101.700 1.00 27.69 ? 509 PRO A N     1 
ATOM   3517 C  CA    . PRO A 1 509 ? 87.978  118.854 101.055 1.00 27.69 ? 509 PRO A CA    1 
ATOM   3518 C  C     . PRO A 1 509 ? 89.132  119.794 101.361 1.00 27.69 ? 509 PRO A C     1 
ATOM   3519 O  O     . PRO A 1 509 ? 89.400  120.705 100.568 1.00 27.69 ? 509 PRO A O     1 
ATOM   3520 C  CB    . PRO A 1 509 ? 86.652  119.400 101.604 1.00 27.69 ? 509 PRO A CB    1 
ATOM   3521 C  CG    . PRO A 1 509 ? 85.914  118.202 102.110 1.00 27.69 ? 509 PRO A CG    1 
ATOM   3522 C  CD    . PRO A 1 509 ? 86.959  117.259 102.600 1.00 27.69 ? 509 PRO A CD    1 
ATOM   3523 N  N     . ARG A 1 510 ? 89.823  119.610 102.481 1.00 23.38 ? 510 ARG A N     1 
ATOM   3524 C  CA    . ARG A 1 510 ? 90.836  120.555 102.931 1.00 23.38 ? 510 ARG A CA    1 
ATOM   3525 C  C     . ARG A 1 510 ? 92.223  120.276 102.367 1.00 23.38 ? 510 ARG A C     1 
ATOM   3526 O  O     . ARG A 1 510 ? 93.147  121.043 102.646 1.00 23.38 ? 510 ARG A O     1 
ATOM   3527 C  CB    . ARG A 1 510 ? 90.901  120.568 104.462 1.00 23.38 ? 510 ARG A CB    1 
ATOM   3528 C  CG    . ARG A 1 510 ? 89.728  121.266 105.130 1.00 23.38 ? 510 ARG A CG    1 
ATOM   3529 C  CD    . ARG A 1 510 ? 90.059  121.669 106.560 1.00 23.38 ? 510 ARG A CD    1 
ATOM   3530 N  NE    . ARG A 1 510 ? 89.909  120.563 107.497 1.00 23.38 ? 510 ARG A NE    1 
ATOM   3531 C  CZ    . ARG A 1 510 ? 89.087  120.566 108.538 1.00 23.38 ? 510 ARG A CZ    1 
ATOM   3532 N  NH1   . ARG A 1 510 ? 88.324  121.610 108.812 1.00 23.38 ? 510 ARG A NH1   1 
ATOM   3533 N  NH2   . ARG A 1 510 ? 89.028  119.494 109.321 1.00 23.38 ? 510 ARG A NH2   1 
ATOM   3534 N  N     . CYS A 1 511 ? 92.398  119.205 101.588 1.00 23.56 ? 511 CYS A N     1 
ATOM   3535 C  CA    . CYS A 1 511 ? 93.708  118.929 101.004 1.00 23.56 ? 511 CYS A CA    1 
ATOM   3536 C  C     . CYS A 1 511 ? 94.107  119.988 99.986  1.00 23.56 ? 511 CYS A C     1 
ATOM   3537 O  O     . CYS A 1 511 ? 95.298  120.258 99.808  1.00 23.56 ? 511 CYS A O     1 
ATOM   3538 C  CB    . CYS A 1 511 ? 93.721  117.549 100.352 1.00 23.56 ? 511 CYS A CB    1 
ATOM   3539 S  SG    . CYS A 1 511 ? 93.769  116.180 101.508 1.00 23.56 ? 511 CYS A SG    1 
ATOM   3540 N  N     . GLY A 1 512 ? 93.134  120.582 99.296  1.00 23.37 ? 512 GLY A N     1 
ATOM   3541 C  CA    . GLY A 1 512 ? 93.456  121.640 98.355  1.00 23.37 ? 512 GLY A CA    1 
ATOM   3542 C  C     . GLY A 1 512 ? 93.954  122.900 99.036  1.00 23.37 ? 512 GLY A C     1 
ATOM   3543 O  O     . GLY A 1 512 ? 94.869  123.562 98.541  1.00 23.37 ? 512 GLY A O     1 
ATOM   3544 N  N     . GLU A 1 513 ? 93.358  123.251 100.177 1.00 25.56 ? 513 GLU A N     1 
ATOM   3545 C  CA    . GLU A 1 513 ? 93.723  124.470 100.886 1.00 25.56 ? 513 GLU A CA    1 
ATOM   3546 C  C     . GLU A 1 513 ? 95.020  124.336 101.668 1.00 25.56 ? 513 GLU A C     1 
ATOM   3547 O  O     . GLU A 1 513 ? 95.583  125.351 102.087 1.00 25.56 ? 513 GLU A O     1 
ATOM   3548 C  CB    . GLU A 1 513 ? 92.603  124.881 101.839 1.00 25.56 ? 513 GLU A CB    1 
ATOM   3549 C  CG    . GLU A 1 513 ? 91.481  125.652 101.183 1.00 25.56 ? 513 GLU A CG    1 
ATOM   3550 C  CD    . GLU A 1 513 ? 90.225  125.662 102.026 1.00 25.56 ? 513 GLU A CD    1 
ATOM   3551 O  OE1   . GLU A 1 513 ? 90.344  125.662 103.268 1.00 25.56 ? 513 GLU A OE1   1 
ATOM   3552 O  OE2   . GLU A 1 513 ? 89.118  125.665 101.448 1.00 25.56 ? 513 GLU A OE2   1 
ATOM   3553 N  N     . LEU A 1 514 ? 95.504  123.120 101.874 1.00 20.35 ? 514 LEU A N     1 
ATOM   3554 C  CA    . LEU A 1 514 ? 96.752  122.897 102.583 1.00 20.35 ? 514 LEU A CA    1 
ATOM   3555 C  C     . LEU A 1 514 ? 97.941  122.757 101.641 1.00 20.35 ? 514 LEU A C     1 
ATOM   3556 O  O     . LEU A 1 514 ? 99.004  122.290 102.065 1.00 20.35 ? 514 LEU A O     1 
ATOM   3557 C  CB    . LEU A 1 514 ? 96.627  121.660 103.468 1.00 20.35 ? 514 LEU A CB    1 
ATOM   3558 C  CG    . LEU A 1 514 ? 95.823  121.842 104.753 1.00 20.35 ? 514 LEU A CG    1 
ATOM   3559 C  CD1   . LEU A 1 514 ? 95.762  120.544 105.517 1.00 20.35 ? 514 LEU A CD1   1 
ATOM   3560 C  CD2   . LEU A 1 514 ? 96.433  122.930 105.609 1.00 20.35 ? 514 LEU A CD2   1 
ATOM   3561 N  N     . ILE A 1 515 ? 97.776  123.126 100.374 1.00 21.79 ? 515 ILE A N     1 
ATOM   3562 C  CA    . ILE A 1 515 ? 98.874  123.217 99.423  1.00 21.79 ? 515 ILE A CA    1 
ATOM   3563 C  C     . ILE A 1 515 ? 99.241  124.667 99.138  1.00 21.79 ? 515 ILE A C     1 
ATOM   3564 O  O     . ILE A 1 515 ? 100.421 125.002 99.015  1.00 21.79 ? 515 ILE A O     1 
ATOM   3565 C  CB    . ILE A 1 515 ? 98.505  122.474 98.122  1.00 21.79 ? 515 ILE A CB    1 
ATOM   3566 C  CG1   . ILE A 1 515 ? 98.326  120.981 98.386  1.00 21.79 ? 515 ILE A CG1   1 
ATOM   3567 C  CG2   . ILE A 1 515 ? 99.563  122.688 97.062  1.00 21.79 ? 515 ILE A CG2   1 
ATOM   3568 C  CD1   . ILE A 1 515 ? 97.626  120.260 97.267  1.00 21.79 ? 515 ILE A CD1   1 
ATOM   3569 N  N     . SER A 1 516 ? 98.229  125.530 99.036  1.00 23.98 ? 516 SER A N     1 
ATOM   3570 C  CA    . SER A 1 516 ? 98.473  126.953 98.833  1.00 23.98 ? 516 SER A CA    1 
ATOM   3571 C  C     . SER A 1 516 ? 99.319  127.528 99.958  1.00 23.98 ? 516 SER A C     1 
ATOM   3572 O  O     . SER A 1 516 ? 100.186 128.379 99.725  1.00 23.98 ? 516 SER A O     1 
ATOM   3573 C  CB    . SER A 1 516 ? 97.143  127.699 98.736  1.00 23.98 ? 516 SER A CB    1 
ATOM   3574 O  OG    . SER A 1 516 ? 96.315  127.138 97.735  1.00 23.98 ? 516 SER A OG    1 
ATOM   3575 N  N     . LEU A 1 517 ? 99.084  127.067 101.188 1.00 22.22 ? 517 LEU A N     1 
ATOM   3576 C  CA    . LEU A 1 517 ? 99.835  127.570 102.331 1.00 22.22 ? 517 LEU A CA    1 
ATOM   3577 C  C     . LEU A 1 517 ? 101.314 127.224 102.220 1.00 22.22 ? 517 LEU A C     1 
ATOM   3578 O  O     . LEU A 1 517 ? 102.181 128.085 102.424 1.00 22.22 ? 517 LEU A O     1 
ATOM   3579 C  CB    . LEU A 1 517 ? 99.242  127.004 103.617 1.00 22.22 ? 517 LEU A CB    1 
ATOM   3580 C  CG    . LEU A 1 517 ? 99.457  127.814 104.886 1.00 22.22 ? 517 LEU A CG    1 
ATOM   3581 C  CD1   . LEU A 1 517 ? 98.511  128.989 104.894 1.00 22.22 ? 517 LEU A CD1   1 
ATOM   3582 C  CD2   . LEU A 1 517 ? 99.234  126.933 106.090 1.00 22.22 ? 517 LEU A CD2   1 
ATOM   3583 N  N     . LYS A 1 518 ? 101.624 125.968 101.893 1.00 19.28 ? 518 LYS A N     1 
ATOM   3584 C  CA    . LYS A 1 518 ? 103.018 125.566 101.745 1.00 19.28 ? 518 LYS A CA    1 
ATOM   3585 C  C     . LYS A 1 518 ? 103.686 126.311 100.592 1.00 19.28 ? 518 LYS A C     1 
ATOM   3586 O  O     . LYS A 1 518 ? 104.854 126.718 100.692 1.00 19.28 ? 518 LYS A O     1 
ATOM   3587 C  CB    . LYS A 1 518 ? 103.096 124.055 101.549 1.00 19.28 ? 518 LYS A CB    1 
ATOM   3588 C  CG    . LYS A 1 518 ? 104.373 123.570 100.926 1.00 19.28 ? 518 LYS A CG    1 
ATOM   3589 C  CD    . LYS A 1 518 ? 104.626 122.129 101.283 1.00 19.28 ? 518 LYS A CD    1 
ATOM   3590 C  CE    . LYS A 1 518 ? 105.814 121.589 100.522 1.00 19.28 ? 518 LYS A CE    1 
ATOM   3591 N  NZ    . LYS A 1 518 ? 106.386 120.383 101.176 1.00 19.28 ? 518 LYS A NZ    1 
ATOM   3592 N  N     . ARG A 1 519 ? 102.955 126.509 99.492  1.00 27.33 ? 519 ARG A N     1 
ATOM   3593 C  CA    . ARG A 1 519 ? 103.497 127.288 98.384  1.00 27.33 ? 519 ARG A CA    1 
ATOM   3594 C  C     . ARG A 1 519 ? 103.838 128.706 98.825  1.00 27.33 ? 519 ARG A C     1 
ATOM   3595 O  O     . ARG A 1 519 ? 104.913 129.228 98.493  1.00 27.33 ? 519 ARG A O     1 
ATOM   3596 C  CB    . ARG A 1 519 ? 102.503 127.311 97.225  1.00 27.33 ? 519 ARG A CB    1 
ATOM   3597 C  CG    . ARG A 1 519 ? 102.972 128.103 96.022  1.00 27.33 ? 519 ARG A CG    1 
ATOM   3598 C  CD    . ARG A 1 519 ? 101.952 128.058 94.899  1.00 27.33 ? 519 ARG A CD    1 
ATOM   3599 N  NE    . ARG A 1 519 ? 100.702 128.715 95.261  1.00 27.33 ? 519 ARG A NE    1 
ATOM   3600 C  CZ    . ARG A 1 519 ? 99.513  128.128 95.244  1.00 27.33 ? 519 ARG A CZ    1 
ATOM   3601 N  NH1   . ARG A 1 519 ? 99.371  126.863 94.884  1.00 27.33 ? 519 ARG A NH1   1 
ATOM   3602 N  NH2   . ARG A 1 519 ? 98.439  128.828 95.597  1.00 27.33 ? 519 ARG A NH2   1 
ATOM   3603 N  N     . ASP A 1 520 ? 102.941 129.339 99.587  1.00 25.90 ? 520 ASP A N     1 
ATOM   3604 C  CA    . ASP A 1 520 ? 103.208 130.683 100.087 1.00 25.90 ? 520 ASP A CA    1 
ATOM   3605 C  C     . ASP A 1 520 ? 104.449 130.704 100.966 1.00 25.90 ? 520 ASP A C     1 
ATOM   3606 O  O     . ASP A 1 520 ? 105.283 131.612 100.857 1.00 25.90 ? 520 ASP A O     1 
ATOM   3607 C  CB    . ASP A 1 520 ? 102.000 131.205 100.864 1.00 25.90 ? 520 ASP A CB    1 
ATOM   3608 C  CG    . ASP A 1 520 ? 100.801 131.460 99.977  1.00 25.90 ? 520 ASP A CG    1 
ATOM   3609 O  OD1   . ASP A 1 520 ? 100.853 131.093 98.787  1.00 25.90 ? 520 ASP A OD1   1 
ATOM   3610 O  OD2   . ASP A 1 520 ? 99.802  132.024 100.468 1.00 25.90 ? 520 ASP A OD2   1 
ATOM   3611 N  N     . ILE A 1 521 ? 104.596 129.703 101.834 1.00 21.64 ? 521 ILE A N     1 
ATOM   3612 C  CA    . ILE A 1 521 ? 105.731 129.677 102.755 1.00 21.64 ? 521 ILE A CA    1 
ATOM   3613 C  C     . ILE A 1 521 ? 107.046 129.591 101.986 1.00 21.64 ? 521 ILE A C     1 
ATOM   3614 O  O     . ILE A 1 521 ? 108.001 130.339 102.254 1.00 21.64 ? 521 ILE A O     1 
ATOM   3615 C  CB    . ILE A 1 521 ? 105.585 128.510 103.744 1.00 21.64 ? 521 ILE A CB    1 
ATOM   3616 C  CG1   . ILE A 1 521 ? 104.418 128.758 104.692 1.00 21.64 ? 521 ILE A CG1   1 
ATOM   3617 C  CG2   . ILE A 1 521 ? 106.853 128.338 104.536 1.00 21.64 ? 521 ILE A CG2   1 
ATOM   3618 C  CD1   . ILE A 1 521 ? 104.121 127.594 105.603 1.00 21.64 ? 521 ILE A CD1   1 
ATOM   3619 N  N     . VAL A 1 522 ? 107.118 128.676 101.015 1.00 24.01 ? 522 VAL A N     1 
ATOM   3620 C  CA    . VAL A 1 522 ? 108.362 128.497 100.267 1.00 24.01 ? 522 VAL A CA    1 
ATOM   3621 C  C     . VAL A 1 522 ? 108.675 129.735 99.431  1.00 24.01 ? 522 VAL A C     1 
ATOM   3622 O  O     . VAL A 1 522 ? 109.840 130.146 99.303  1.00 24.01 ? 522 VAL A O     1 
ATOM   3623 C  CB    . VAL A 1 522 ? 108.288 127.226 99.407  1.00 24.01 ? 522 VAL A CB    1 
ATOM   3624 C  CG1   . VAL A 1 522 ? 109.491 127.137 98.511  1.00 24.01 ? 522 VAL A CG1   1 
ATOM   3625 C  CG2   . VAL A 1 522 ? 108.220 126.001 100.298 1.00 24.01 ? 522 VAL A CG2   1 
ATOM   3626 N  N     . GLU A 1 523 ? 107.645 130.360 98.861  1.00 32.07 ? 523 GLU A N     1 
ATOM   3627 C  CA    . GLU A 1 523 ? 107.882 131.575 98.094  1.00 32.07 ? 523 GLU A CA    1 
ATOM   3628 C  C     . GLU A 1 523 ? 108.405 132.699 98.987  1.00 32.07 ? 523 GLU A C     1 
ATOM   3629 O  O     . GLU A 1 523 ? 109.263 133.488 98.566  1.00 32.07 ? 523 GLU A O     1 
ATOM   3630 C  CB    . GLU A 1 523 ? 106.602 131.980 97.368  1.00 32.07 ? 523 GLU A CB    1 
ATOM   3631 C  CG    . GLU A 1 523 ? 106.833 132.556 95.983  1.00 32.07 ? 523 GLU A CG    1 
ATOM   3632 C  CD    . GLU A 1 523 ? 105.543 132.782 95.220  1.00 32.07 ? 523 GLU A CD    1 
ATOM   3633 O  OE1   . GLU A 1 523 ? 104.460 132.536 95.791  1.00 32.07 ? 523 GLU A OE1   1 
ATOM   3634 O  OE2   . GLU A 1 523 ? 105.612 133.204 94.046  1.00 32.07 ? 523 GLU A OE2   1 
ATOM   3635 N  N     . ILE A 1 524 ? 107.918 132.778 100.231 1.00 27.64 ? 524 ILE A N     1 
ATOM   3636 C  CA    . ILE A 1 524 ? 108.453 133.761 101.174 1.00 27.64 ? 524 ILE A CA    1 
ATOM   3637 C  C     . ILE A 1 524 ? 109.922 133.483 101.463 1.00 27.64 ? 524 ILE A C     1 
ATOM   3638 O  O     . ILE A 1 524 ? 110.738 134.412 101.555 1.00 27.64 ? 524 ILE A O     1 
ATOM   3639 C  CB    . ILE A 1 524 ? 107.640 133.767 102.477 1.00 27.64 ? 524 ILE A CB    1 
ATOM   3640 C  CG1   . ILE A 1 524 ? 106.230 134.288 102.254 1.00 27.64 ? 524 ILE A CG1   1 
ATOM   3641 C  CG2   . ILE A 1 524 ? 108.302 134.669 103.493 1.00 27.64 ? 524 ILE A CG2   1 
ATOM   3642 C  CD1   . ILE A 1 524 ? 105.442 134.300 103.525 1.00 27.64 ? 524 ILE A CD1   1 
ATOM   3643 N  N     . LYS A 1 525 ? 110.274 132.209 101.664 1.00 24.44 ? 525 LYS A N     1 
ATOM   3644 C  CA    . LYS A 1 525 ? 111.680 131.862 101.872 1.00 24.44 ? 525 LYS A CA    1 
ATOM   3645 C  C     . LYS A 1 525 ? 112.552 132.387 100.737 1.00 24.44 ? 525 LYS A C     1 
ATOM   3646 O  O     . LYS A 1 525 ? 113.589 133.024 100.974 1.00 24.44 ? 525 LYS A O     1 
ATOM   3647 C  CB    . LYS A 1 525 ? 111.844 130.350 101.988 1.00 24.44 ? 525 LYS A CB    1 
ATOM   3648 C  CG    . LYS A 1 525 ? 111.617 129.793 103.360 1.00 24.44 ? 525 LYS A CG    1 
ATOM   3649 C  CD    . LYS A 1 525 ? 111.676 128.284 103.322 1.00 24.44 ? 525 LYS A CD    1 
ATOM   3650 C  CE    . LYS A 1 525 ? 113.018 127.803 102.817 1.00 24.44 ? 525 LYS A CE    1 
ATOM   3651 N  NZ    . LYS A 1 525 ? 113.123 126.323 102.890 1.00 24.44 ? 525 LYS A NZ    1 
ATOM   3652 N  N     . SER A 1 526 ? 112.139 132.132 99.495  1.00 28.41 ? 526 SER A N     1 
ATOM   3653 C  CA    . SER A 1 526 ? 112.912 132.611 98.351  1.00 28.41 ? 526 SER A CA    1 
ATOM   3654 C  C     . SER A 1 526 ? 112.983 134.136 98.321  1.00 28.41 ? 526 SER A C     1 
ATOM   3655 O  O     . SER A 1 526 ? 114.018 134.712 97.955  1.00 28.41 ? 526 SER A O     1 
ATOM   3656 C  CB    . SER A 1 526 ? 112.314 132.075 97.052  1.00 28.41 ? 526 SER A CB    1 
ATOM   3657 O  OG    . SER A 1 526 ? 112.589 130.693 96.906  1.00 28.41 ? 526 SER A OG    1 
ATOM   3658 N  N     . ALA A 1 527 ? 111.886 134.809 98.686  1.00 30.16 ? 527 ALA A N     1 
ATOM   3659 C  CA    . ALA A 1 527 ? 111.891 136.270 98.702  1.00 30.16 ? 527 ALA A CA    1 
ATOM   3660 C  C     . ALA A 1 527 ? 112.914 136.812 99.692  1.00 30.16 ? 527 ALA A C     1 
ATOM   3661 O  O     . ALA A 1 527 ? 113.648 137.758 99.384  1.00 30.16 ? 527 ALA A O     1 
ATOM   3662 C  CB    . ALA A 1 527 ? 110.496 136.797 99.033  1.00 30.16 ? 527 ALA A CB    1 
ATOM   3663 N  N     . ILE A 1 528 ? 112.981 136.222 100.884 1.00 30.82 ? 528 ILE A N     1 
ATOM   3664 C  CA    . ILE A 1 528 ? 113.977 136.641 101.869 1.00 30.82 ? 528 ILE A CA    1 
ATOM   3665 C  C     . ILE A 1 528 ? 115.386 136.381 101.346 1.00 30.82 ? 528 ILE A C     1 
ATOM   3666 O  O     . ILE A 1 528 ? 116.307 137.201 101.527 1.00 30.82 ? 528 ILE A O     1 
ATOM   3667 C  CB    . ILE A 1 528 ? 113.726 135.919 103.206 1.00 30.82 ? 528 ILE A CB    1 
ATOM   3668 C  CG1   . ILE A 1 528 ? 112.635 136.626 104.007 1.00 30.82 ? 528 ILE A CG1   1 
ATOM   3669 C  CG2   . ILE A 1 528 ? 115.006 135.812 104.021 1.00 30.82 ? 528 ILE A CG2   1 
ATOM   3670 C  CD1   . ILE A 1 528 ? 112.206 135.853 105.223 1.00 30.82 ? 528 ILE A CD1   1 
ATOM   3671 N  N     . LYS A 1 529 ? 115.578 135.227 100.698 1.00 35.13 ? 529 LYS A N     1 
ATOM   3672 C  CA    . LYS A 1 529 ? 116.894 134.873 100.180 1.00 35.13 ? 529 LYS A CA    1 
ATOM   3673 C  C     . LYS A 1 529 ? 117.378 135.891 99.157  1.00 35.13 ? 529 LYS A C     1 
ATOM   3674 O  O     . LYS A 1 529 ? 118.556 136.263 99.155  1.00 35.13 ? 529 LYS A O     1 
ATOM   3675 C  CB    . LYS A 1 529 ? 116.855 133.477 99.568  1.00 35.13 ? 529 LYS A CB    1 
ATOM   3676 C  CG    . LYS A 1 529 ? 118.183 132.788 99.544  1.00 35.13 ? 529 LYS A CG    1 
ATOM   3677 C  CD    . LYS A 1 529 ? 118.053 131.371 99.024  1.00 35.13 ? 529 LYS A CD    1 
ATOM   3678 C  CE    . LYS A 1 529 ? 117.382 130.470 100.034 1.00 35.13 ? 529 LYS A CE    1 
ATOM   3679 N  NZ    . LYS A 1 529 ? 118.176 130.371 101.282 1.00 35.13 ? 529 LYS A NZ    1 
ATOM   3680 N  N     . GLU A 1 530 ? 116.491 136.353 98.272  1.00 44.48 ? 530 GLU A N     1 
ATOM   3681 C  CA    . GLU A 1 530 ? 116.927 137.389 97.339  1.00 44.48 ? 530 GLU A CA    1 
ATOM   3682 C  C     . GLU A 1 530 ? 117.037 138.756 98.002  1.00 44.48 ? 530 GLU A C     1 
ATOM   3683 O  O     . GLU A 1 530 ? 117.830 139.584 97.538  1.00 44.48 ? 530 GLU A O     1 
ATOM   3684 C  CB    . GLU A 1 530 ? 116.002 137.527 96.132  1.00 44.48 ? 530 GLU A CB    1 
ATOM   3685 C  CG    . GLU A 1 530 ? 114.693 138.211 96.424  1.00 44.48 ? 530 GLU A CG    1 
ATOM   3686 C  CD    . GLU A 1 530 ? 113.942 138.545 95.161  1.00 44.48 ? 530 GLU A CD    1 
ATOM   3687 O  OE1   . GLU A 1 530 ? 114.477 138.265 94.072  1.00 44.48 ? 530 GLU A OE1   1 
ATOM   3688 O  OE2   . GLU A 1 530 ? 112.830 139.104 95.252  1.00 44.48 ? 530 GLU A OE2   1 
ATOM   3689 N  N     . PHE A 1 531 ? 116.238 139.026 99.043  1.00 41.91 ? 531 PHE A N     1 
ATOM   3690 C  CA    . PHE A 1 531 ? 116.363 140.278 99.785  1.00 41.91 ? 531 PHE A CA    1 
ATOM   3691 C  C     . PHE A 1 531 ? 117.755 140.462 100.357 1.00 41.91 ? 531 PHE A C     1 
ATOM   3692 O  O     . PHE A 1 531 ? 118.298 141.571 100.304 1.00 41.91 ? 531 PHE A O     1 
ATOM   3693 C  CB    . PHE A 1 531 ? 115.334 140.329 100.914 1.00 41.91 ? 531 PHE A CB    1 
ATOM   3694 C  CG    . PHE A 1 531 ? 115.263 141.657 101.619 1.00 41.91 ? 531 PHE A CG    1 
ATOM   3695 C  CD1   . PHE A 1 531 ? 116.169 141.969 102.623 1.00 41.91 ? 531 PHE A CD1   1 
ATOM   3696 C  CD2   . PHE A 1 531 ? 114.296 142.587 101.288 1.00 41.91 ? 531 PHE A CD2   1 
ATOM   3697 C  CE1   . PHE A 1 531 ? 116.115 143.177 103.277 1.00 41.91 ? 531 PHE A CE1   1 
ATOM   3698 C  CE2   . PHE A 1 531 ? 114.239 143.802 101.941 1.00 41.91 ? 531 PHE A CE2   1 
ATOM   3699 C  CZ    . PHE A 1 531 ? 115.150 144.096 102.937 1.00 41.91 ? 531 PHE A CZ    1 
ATOM   3700 N  N     . LYS A 1 532 ? 118.330 139.407 100.931 1.00 40.14 ? 532 LYS A N     1 
ATOM   3701 C  CA    . LYS A 1 532 ? 119.676 139.539 101.488 1.00 40.14 ? 532 LYS A CA    1 
ATOM   3702 C  C     . LYS A 1 532 ? 120.661 140.040 100.432 1.00 40.14 ? 532 LYS A C     1 
ATOM   3703 O  O     . LYS A 1 532 ? 121.334 141.064 100.624 1.00 40.14 ? 532 LYS A O     1 
ATOM   3704 C  CB    . LYS A 1 532 ? 120.135 138.203 102.070 1.00 40.14 ? 532 LYS A CB    1 
ATOM   3705 C  CG    . LYS A 1 532 ? 119.494 137.867 103.403 1.00 40.14 ? 532 LYS A CG    1 
ATOM   3706 C  CD    . LYS A 1 532 ? 119.683 136.410 103.770 1.00 40.14 ? 532 LYS A CD    1 
ATOM   3707 C  CE    . LYS A 1 532 ? 121.040 136.144 104.367 1.00 40.14 ? 532 LYS A CE    1 
ATOM   3708 N  NZ    . LYS A 1 532 ? 121.236 134.688 104.577 1.00 40.14 ? 532 LYS A NZ    1 
ATOM   3709 N  N     . ALA A 1 533 ? 120.710 139.362 99.284  1.00 46.81 ? 533 ALA A N     1 
ATOM   3710 C  CA    . ALA A 1 533 ? 121.674 139.690 98.241  1.00 46.81 ? 533 ALA A CA    1 
ATOM   3711 C  C     . ALA A 1 533 ? 121.394 141.041 97.595  1.00 46.81 ? 533 ALA A C     1 
ATOM   3712 O  O     . ALA A 1 533 ? 122.329 141.803 97.327  1.00 46.81 ? 533 ALA A O     1 
ATOM   3713 C  CB    . ALA A 1 533 ? 121.685 138.593 97.180  1.00 46.81 ? 533 ALA A CB    1 
ATOM   3714 N  N     . CYS A 1 534 ? 120.124 141.356 97.324  1.00 50.15 ? 534 CYS A N     1 
ATOM   3715 C  CA    . CYS A 1 534 ? 119.812 142.606 96.638  1.00 50.15 ? 534 CYS A CA    1 
ATOM   3716 C  C     . CYS A 1 534 ? 120.219 143.815 97.470  1.00 50.15 ? 534 CYS A C     1 
ATOM   3717 O  O     . CYS A 1 534 ? 120.783 144.780 96.941  1.00 50.15 ? 534 CYS A O     1 
ATOM   3718 C  CB    . CYS A 1 534 ? 118.323 142.667 96.299  1.00 50.15 ? 534 CYS A CB    1 
ATOM   3719 S  SG    . CYS A 1 534 ? 117.880 141.876 94.737  1.00 50.15 ? 534 CYS A SG    1 
ATOM   3720 N  N     . GLN A 1 535 ? 119.941 143.785 98.775  1.00 50.02 ? 535 GLN A N     1 
ATOM   3721 C  CA    . GLN A 1 535 ? 120.347 144.899 99.625  1.00 50.02 ? 535 GLN A CA    1 
ATOM   3722 C  C     . GLN A 1 535 ? 121.843 144.881 99.905  1.00 50.02 ? 535 GLN A C     1 
ATOM   3723 O  O     . GLN A 1 535 ? 122.426 145.938 100.171 1.00 50.02 ? 535 GLN A O     1 
ATOM   3724 C  CB    . GLN A 1 535 ? 119.563 144.897 100.934 1.00 50.02 ? 535 GLN A CB    1 
ATOM   3725 C  CG    . GLN A 1 535 ? 118.198 145.546 100.833 1.00 50.02 ? 535 GLN A CG    1 
ATOM   3726 C  CD    . GLN A 1 535 ? 117.763 146.166 102.142 1.00 50.02 ? 535 GLN A CD    1 
ATOM   3727 O  OE1   . GLN A 1 535 ? 118.183 145.735 103.214 1.00 50.02 ? 535 GLN A OE1   1 
ATOM   3728 N  NE2   . GLN A 1 535 ? 116.921 147.188 102.062 1.00 50.02 ? 535 GLN A NE2   1 
ATOM   3729 N  N     . ARG A 1 536 ? 122.486 143.709 99.863  1.00 56.90 ? 536 ARG A N     1 
ATOM   3730 C  CA    . ARG A 1 536 ? 123.942 143.709 99.943  1.00 56.90 ? 536 ARG A CA    1 
ATOM   3731 C  C     . ARG A 1 536 ? 124.558 144.392 98.728  1.00 56.90 ? 536 ARG A C     1 
ATOM   3732 O  O     . ARG A 1 536 ? 125.570 145.092 98.848  1.00 56.90 ? 536 ARG A O     1 
ATOM   3733 C  CB    . ARG A 1 536 ? 124.479 142.287 100.085 1.00 56.90 ? 536 ARG A CB    1 
ATOM   3734 C  CG    . ARG A 1 536 ? 125.993 142.249 100.145 1.00 56.90 ? 536 ARG A CG    1 
ATOM   3735 C  CD    . ARG A 1 536 ? 126.539 140.869 100.438 1.00 56.90 ? 536 ARG A CD    1 
ATOM   3736 N  NE    . ARG A 1 536 ? 127.994 140.900 100.518 1.00 56.90 ? 536 ARG A NE    1 
ATOM   3737 C  CZ    . ARG A 1 536 ? 128.754 139.861 100.834 1.00 56.90 ? 536 ARG A CZ    1 
ATOM   3738 N  NH1   . ARG A 1 536 ? 128.229 138.686 101.137 1.00 56.90 ? 536 ARG A NH1   1 
ATOM   3739 N  NH2   . ARG A 1 536 ? 130.076 140.007 100.853 1.00 56.90 ? 536 ARG A NH2   1 
ATOM   3740 N  N     . GLU A 1 537 ? 123.963 144.205 97.553  1.00 59.97 ? 537 GLU A N     1 
ATOM   3741 C  CA    . GLU A 1 537 ? 124.491 144.783 96.325  1.00 59.97 ? 537 GLU A CA    1 
ATOM   3742 C  C     . GLU A 1 537 ? 123.925 146.161 96.012  1.00 59.97 ? 537 GLU A C     1 
ATOM   3743 O  O     . GLU A 1 537 ? 124.310 146.754 94.998  1.00 59.97 ? 537 GLU A O     1 
ATOM   3744 C  CB    . GLU A 1 537 ? 124.216 143.847 95.145  1.00 59.97 ? 537 GLU A CB    1 
ATOM   3745 C  CG    . GLU A 1 537 ? 124.923 142.512 95.253  1.00 59.97 ? 537 GLU A CG    1 
ATOM   3746 C  CD    . GLU A 1 537 ? 126.425 142.651 95.197  1.00 59.97 ? 537 GLU A CD    1 
ATOM   3747 O  OE1   . GLU A 1 537 ? 126.915 143.571 94.509  1.00 59.97 ? 537 GLU A OE1   1 
ATOM   3748 O  OE2   . GLU A 1 537 ? 127.119 141.844 95.848  1.00 59.97 ? 537 GLU A OE2   1 
ATOM   3749 N  N     . GLY A 1 538 ? 123.027 146.684 96.841  1.00 62.93 ? 538 GLY A N     1 
ATOM   3750 C  CA    . GLY A 1 538 ? 122.452 147.986 96.576  1.00 62.93 ? 538 GLY A CA    1 
ATOM   3751 C  C     . GLY A 1 538 ? 121.566 148.038 95.355  1.00 62.93 ? 538 GLY A C     1 
ATOM   3752 O  O     . GLY A 1 538 ? 121.372 149.115 94.783  1.00 62.93 ? 538 GLY A O     1 
ATOM   3753 N  N     . LEU A 1 539 ? 121.020 146.902 94.937  1.00 62.76 ? 539 LEU A N     1 
ATOM   3754 C  CA    . LEU A 1 539 ? 120.173 146.833 93.758  1.00 62.76 ? 539 LEU A CA    1 
ATOM   3755 C  C     . LEU A 1 539 ? 118.737 147.200 94.136  1.00 62.76 ? 539 LEU A C     1 
ATOM   3756 O  O     . LEU A 1 539 ? 118.458 147.649 95.250  1.00 62.76 ? 539 LEU A O     1 
ATOM   3757 C  CB    . LEU A 1 539 ? 120.266 145.444 93.134  1.00 62.76 ? 539 LEU A CB    1 
ATOM   3758 C  CG    . LEU A 1 539 ? 121.633 145.076 92.559  1.00 62.76 ? 539 LEU A CG    1 
ATOM   3759 C  CD1   . LEU A 1 539 ? 121.644 143.631 92.096  1.00 62.76 ? 539 LEU A CD1   1 
ATOM   3760 C  CD2   . LEU A 1 539 ? 122.009 146.010 91.422  1.00 62.76 ? 539 LEU A CD2   1 
ATOM   3761 N  N     . THR A 1 540 ? 117.810 147.018 93.202  1.00 65.31 ? 540 THR A N     1 
ATOM   3762 C  CA    . THR A 1 540 ? 116.398 147.272 93.440  1.00 65.31 ? 540 THR A CA    1 
ATOM   3763 C  C     . THR A 1 540 ? 115.606 145.988 93.239  1.00 65.31 ? 540 THR A C     1 
ATOM   3764 O  O     . THR A 1 540 ? 115.799 145.277 92.247  1.00 65.31 ? 540 THR A O     1 
ATOM   3765 C  CB    . THR A 1 540 ? 115.866 148.365 92.511  1.00 65.31 ? 540 THR A CB    1 
ATOM   3766 O  OG1   . THR A 1 540 ? 116.695 149.528 92.617  1.00 65.31 ? 540 THR A OG1   1 
ATOM   3767 C  CG2   . THR A 1 540 ? 114.440 148.734 92.891  1.00 65.31 ? 540 THR A CG2   1 
ATOM   3768 N  N     . MET A 1 541 ? 114.716 145.700 94.186  1.00 63.88 ? 541 MET A N     1 
ATOM   3769 C  CA    . MET A 1 541 ? 113.926 144.477 94.145  1.00 63.88 ? 541 MET A CA    1 
ATOM   3770 C  C     . MET A 1 541 ? 113.069 144.431 92.886  1.00 63.88 ? 541 MET A C     1 
ATOM   3771 O  O     . MET A 1 541 ? 112.539 145.454 92.444  1.00 63.88 ? 541 MET A O     1 
ATOM   3772 C  CB    . MET A 1 541 ? 113.046 144.385 95.392  1.00 63.88 ? 541 MET A CB    1 
ATOM   3773 C  CG    . MET A 1 541 ? 112.263 143.089 95.515  1.00 63.88 ? 541 MET A CG    1 
ATOM   3774 S  SD    . MET A 1 541 ? 111.248 143.012 97.002  1.00 63.88 ? 541 MET A SD    1 
ATOM   3775 C  CE    . MET A 1 541 ? 112.511 142.800 98.251  1.00 63.88 ? 541 MET A CE    1 
ATOM   3776 N  N     . SER A 1 542 ? 112.937 143.237 92.311  1.00 63.31 ? 542 SER A N     1 
ATOM   3777 C  CA    . SER A 1 542 ? 112.154 143.053 91.099  1.00 63.31 ? 542 SER A CA    1 
ATOM   3778 C  C     . SER A 1 542 ? 110.690 143.395 91.361  1.00 63.31 ? 542 SER A C     1 
ATOM   3779 O  O     . SER A 1 542 ? 110.202 143.344 92.493  1.00 63.31 ? 542 SER A O     1 
ATOM   3780 C  CB    . SER A 1 542 ? 112.295 141.620 90.595  1.00 63.31 ? 542 SER A CB    1 
ATOM   3781 O  OG    . SER A 1 542 ? 111.670 140.712 91.482  1.00 63.31 ? 542 SER A OG    1 
ATOM   3782 N  N     . GLU A 1 543 ? 109.977 143.759 90.295  1.00 66.38 ? 543 GLU A N     1 
ATOM   3783 C  CA    . GLU A 1 543 ? 108.580 144.140 90.460  1.00 66.38 ? 543 GLU A CA    1 
ATOM   3784 C  C     . GLU A 1 543 ? 107.708 142.944 90.807  1.00 66.38 ? 543 GLU A C     1 
ATOM   3785 O  O     . GLU A 1 543 ? 106.629 143.119 91.384  1.00 66.38 ? 543 GLU A O     1 
ATOM   3786 C  CB    . GLU A 1 543 ? 108.049 144.818 89.195  1.00 66.38 ? 543 GLU A CB    1 
ATOM   3787 C  CG    . GLU A 1 543 ? 107.680 143.860 88.071  1.00 66.38 ? 543 GLU A CG    1 
ATOM   3788 C  CD    . GLU A 1 543 ? 108.853 143.523 87.178  1.00 66.38 ? 543 GLU A CD    1 
ATOM   3789 O  OE1   . GLU A 1 543 ? 109.997 143.841 87.558  1.00 66.38 ? 543 GLU A OE1   1 
ATOM   3790 O  OE2   . GLU A 1 543 ? 108.630 142.935 86.098  1.00 66.38 ? 543 GLU A OE2   1 
ATOM   3791 N  N     . GLU A 1 544 ? 108.153 141.730 90.474  1.00 63.57 ? 544 GLU A N     1 
ATOM   3792 C  CA    . GLU A 1 544 ? 107.351 140.546 90.764  1.00 63.57 ? 544 GLU A CA    1 
ATOM   3793 C  C     . GLU A 1 544 ? 107.242 140.300 92.264  1.00 63.57 ? 544 GLU A C     1 
ATOM   3794 O  O     . GLU A 1 544 ? 106.140 140.126 92.791  1.00 63.57 ? 544 GLU A O     1 
ATOM   3795 C  CB    . GLU A 1 544 ? 107.935 139.327 90.050  1.00 63.57 ? 544 GLU A CB    1 
ATOM   3796 C  CG    . GLU A 1 544 ? 107.803 139.395 88.542  1.00 63.57 ? 544 GLU A CG    1 
ATOM   3797 C  CD    . GLU A 1 544 ? 109.077 139.845 87.865  1.00 63.57 ? 544 GLU A CD    1 
ATOM   3798 O  OE1   . GLU A 1 544 ? 110.078 140.074 88.577  1.00 63.57 ? 544 GLU A OE1   1 
ATOM   3799 O  OE2   . GLU A 1 544 ? 109.075 139.972 86.622  1.00 63.57 ? 544 GLU A OE2   1 
ATOM   3800 N  N     . THR A 1 545 ? 108.373 140.292 92.973  1.00 53.44 ? 545 THR A N     1 
ATOM   3801 C  CA    . THR A 1 545 ? 108.330 140.076 94.417  1.00 53.44 ? 545 THR A CA    1 
ATOM   3802 C  C     . THR A 1 545 ? 107.624 141.224 95.127  1.00 53.44 ? 545 THR A C     1 
ATOM   3803 O  O     . THR A 1 545 ? 106.838 141.002 96.055  1.00 53.44 ? 545 THR A O     1 
ATOM   3804 C  CB    . THR A 1 545 ? 109.741 139.897 94.970  1.00 53.44 ? 545 THR A CB    1 
ATOM   3805 O  OG1   . THR A 1 545 ? 110.333 138.727 94.399  1.00 53.44 ? 545 THR A OG1   1 
ATOM   3806 C  CG2   . THR A 1 545 ? 109.698 139.726 96.468  1.00 53.44 ? 545 THR A CG2   1 
ATOM   3807 N  N     . THR A 1 546 ? 107.890 142.460 94.701  1.00 53.54 ? 546 THR A N     1 
ATOM   3808 C  CA    . THR A 1 546 ? 107.248 143.616 95.318  1.00 53.54 ? 546 THR A CA    1 
ATOM   3809 C  C     . THR A 1 546 ? 105.737 143.572 95.128  1.00 53.54 ? 546 THR A C     1 
ATOM   3810 O  O     . THR A 1 546 ? 104.975 143.906 96.042  1.00 53.54 ? 546 THR A O     1 
ATOM   3811 C  CB    . THR A 1 546 ? 107.825 144.907 94.740  1.00 53.54 ? 546 THR A CB    1 
ATOM   3812 O  OG1   . THR A 1 546 ? 109.255 144.821 94.712  1.00 53.54 ? 546 THR A OG1   1 
ATOM   3813 C  CG2   . THR A 1 546 ? 107.412 146.097 95.588  1.00 53.54 ? 546 THR A CG2   1 
ATOM   3814 N  N     . THR A 1 547 ? 105.285 143.165 93.942  1.00 55.83 ? 547 THR A N     1 
ATOM   3815 C  CA    . THR A 1 547 ? 103.854 143.036 93.697  1.00 55.83 ? 547 THR A CA    1 
ATOM   3816 C  C     . THR A 1 547 ? 103.277 141.833 94.435  1.00 55.83 ? 547 THR A C     1 
ATOM   3817 O  O     . THR A 1 547 ? 102.108 141.847 94.838  1.00 55.83 ? 547 THR A O     1 
ATOM   3818 C  CB    . THR A 1 547 ? 103.595 142.927 92.192  1.00 55.83 ? 547 THR A CB    1 
ATOM   3819 O  OG1   . THR A 1 547 ? 104.102 144.096 91.537  1.00 55.83 ? 547 THR A OG1   1 
ATOM   3820 C  CG2   . THR A 1 547 ? 102.104 142.822 91.904  1.00 55.83 ? 547 THR A CG2   1 
ATOM   3821 N  N     . TRP A 1 548 ? 104.089 140.793 94.637  1.00 45.39 ? 548 TRP A N     1 
ATOM   3822 C  CA    . TRP A 1 548 ? 103.608 139.588 95.301  1.00 45.39 ? 548 TRP A CA    1 
ATOM   3823 C  C     . TRP A 1 548 ? 103.408 139.821 96.794  1.00 45.39 ? 548 TRP A C     1 
ATOM   3824 O  O     . TRP A 1 548 ? 102.455 139.303 97.387  1.00 45.39 ? 548 TRP A O     1 
ATOM   3825 C  CB    . TRP A 1 548 ? 104.588 138.438 95.067  1.00 45.39 ? 548 TRP A CB    1 
ATOM   3826 C  CG    . TRP A 1 548 ? 104.169 137.174 95.724  1.00 45.39 ? 548 TRP A CG    1 
ATOM   3827 C  CD1   . TRP A 1 548 ? 103.064 136.436 95.434  1.00 45.39 ? 548 TRP A CD1   1 
ATOM   3828 C  CD2   . TRP A 1 548 ? 104.818 136.513 96.811  1.00 45.39 ? 548 TRP A CD2   1 
ATOM   3829 N  NE1   . TRP A 1 548 ? 102.994 135.342 96.258  1.00 45.39 ? 548 TRP A NE1   1 
ATOM   3830 C  CE2   . TRP A 1 548 ? 104.061 135.367 97.116  1.00 45.39 ? 548 TRP A CE2   1 
ATOM   3831 C  CE3   . TRP A 1 548 ? 105.972 136.771 97.550  1.00 45.39 ? 548 TRP A CE3   1 
ATOM   3832 C  CZ2   . TRP A 1 548 ? 104.415 134.487 98.129  1.00 45.39 ? 548 TRP A CZ2   1 
ATOM   3833 C  CZ3   . TRP A 1 548 ? 106.323 135.892 98.554  1.00 45.39 ? 548 TRP A CZ3   1 
ATOM   3834 C  CH2   . TRP A 1 548 ? 105.546 134.767 98.836  1.00 45.39 ? 548 TRP A CH2   1 
ATOM   3835 N  N     . LEU A 1 549 ? 104.294 140.592 97.418  1.00 47.19 ? 549 LEU A N     1 
ATOM   3836 C  CA    . LEU A 1 549 ? 104.214 140.867 98.845  1.00 47.19 ? 549 LEU A CA    1 
ATOM   3837 C  C     . LEU A 1 549 ? 103.338 142.062 99.180  1.00 47.19 ? 549 LEU A C     1 
ATOM   3838 O  O     . LEU A 1 549 ? 103.097 142.317 100.362 1.00 47.19 ? 549 LEU A O     1 
ATOM   3839 C  CB    . LEU A 1 549 ? 105.617 141.084 99.417  1.00 47.19 ? 549 LEU A CB    1 
ATOM   3840 C  CG    . LEU A 1 549 ? 106.502 139.842 99.492  1.00 47.19 ? 549 LEU A CG    1 
ATOM   3841 C  CD1   . LEU A 1 549 ? 107.829 140.149 100.157 1.00 47.19 ? 549 LEU A CD1   1 
ATOM   3842 C  CD2   . LEU A 1 549 ? 105.761 138.798 100.287 1.00 47.19 ? 549 LEU A CD2   1 
ATOM   3843 N  N     . SER A 1 550 ? 102.851 142.793 98.185  1.00 51.10 ? 550 SER A N     1 
ATOM   3844 C  CA    . SER A 1 550 ? 102.020 143.965 98.427  1.00 51.10 ? 550 SER A CA    1 
ATOM   3845 C  C     . SER A 1 550 ? 100.542 143.629 98.559  1.00 51.10 ? 550 SER A C     1 
ATOM   3846 O  O     . SER A 1 550 ? 99.753  144.505 98.925  1.00 51.10 ? 550 SER A O     1 
ATOM   3847 C  CB    . SER A 1 550 ? 102.211 144.991 97.305  1.00 51.10 ? 550 SER A CB    1 
ATOM   3848 O  OG    . SER A 1 550 ? 101.712 144.500 96.072  1.00 51.10 ? 550 SER A OG    1 
ATOM   3849 N  N     . GLU A 1 551 ? 100.150 142.387 98.278  1.00 53.36 ? 551 GLU A N     1 
ATOM   3850 C  CA    . GLU A 1 551 ? 98.741  142.021 98.311  1.00 53.36 ? 551 GLU A CA    1 
ATOM   3851 C  C     . GLU A 1 551 ? 98.207  141.884 99.731  1.00 53.36 ? 551 GLU A C     1 
ATOM   3852 O  O     . GLU A 1 551 ? 96.987  141.811 99.917  1.00 53.36 ? 551 GLU A O     1 
ATOM   3853 C  CB    . GLU A 1 551 ? 98.530  140.718 97.538  1.00 53.36 ? 551 GLU A CB    1 
ATOM   3854 C  CG    . GLU A 1 551 ? 99.348  139.550 98.069  1.00 53.36 ? 551 GLU A CG    1 
ATOM   3855 C  CD    . GLU A 1 551 ? 99.473  138.414 97.070  1.00 53.36 ? 551 GLU A CD    1 
ATOM   3856 O  OE1   . GLU A 1 551 ? 98.952  138.548 95.943  1.00 53.36 ? 551 GLU A OE1   1 
ATOM   3857 O  OE2   . GLU A 1 551 ? 100.092 137.384 97.413  1.00 53.36 ? 551 GLU A OE2   1 
ATOM   3858 N  N     . VAL A 1 552 ? 99.086  141.858 100.731 1.00 53.61 ? 552 VAL A N     1 
ATOM   3859 C  CA    . VAL A 1 552 ? 98.709  141.645 102.124 1.00 53.61 ? 552 VAL A CA    1 
ATOM   3860 C  C     . VAL A 1 552 ? 98.911  142.936 102.902 1.00 53.61 ? 552 VAL A C     1 
ATOM   3861 O  O     . VAL A 1 552 ? 99.917  143.635 102.721 1.00 53.61 ? 552 VAL A O     1 
ATOM   3862 C  CB    . VAL A 1 552 ? 99.516  140.485 102.738 1.00 53.61 ? 552 VAL A CB    1 
ATOM   3863 C  CG1   . VAL A 1 552 ? 99.282  140.395 104.234 1.00 53.61 ? 552 VAL A CG1   1 
ATOM   3864 C  CG2   . VAL A 1 552 ? 99.125  139.187 102.070 1.00 53.61 ? 552 VAL A CG2   1 
ATOM   3865 N  N     . GLU A 1 553 ? 97.943  143.261 103.760 1.00 59.28 ? 553 GLU A N     1 
ATOM   3866 C  CA    . GLU A 1 553 ? 98.005  144.481 104.554 1.00 59.28 ? 553 GLU A CA    1 
ATOM   3867 C  C     . GLU A 1 553 ? 99.258  144.509 105.420 1.00 59.28 ? 553 GLU A C     1 
ATOM   3868 O  O     . GLU A 1 553 ? 99.610  143.515 106.061 1.00 59.28 ? 553 GLU A O     1 
ATOM   3869 C  CB    . GLU A 1 553 ? 96.757  144.598 105.429 1.00 59.28 ? 553 GLU A CB    1 
ATOM   3870 C  CG    . GLU A 1 553 ? 96.703  145.862 106.272 1.00 59.28 ? 553 GLU A CG    1 
ATOM   3871 C  CD    . GLU A 1 553 ? 96.601  147.122 105.441 1.00 59.28 ? 553 GLU A CD    1 
ATOM   3872 O  OE1   . GLU A 1 553 ? 96.094  147.048 104.303 1.00 59.28 ? 553 GLU A OE1   1 
ATOM   3873 O  OE2   . GLU A 1 553 ? 97.031  148.189 105.927 1.00 59.28 ? 553 GLU A OE2   1 
ATOM   3874 N  N     . SER A 1 554 ? 99.929  145.655 105.429 1.00 55.81 ? 554 SER A N     1 
ATOM   3875 C  CA    . SER A 1 554 ? 101.155 145.874 106.176 1.00 55.81 ? 554 SER A CA    1 
ATOM   3876 C  C     . SER A 1 554 ? 101.127 147.261 106.799 1.00 55.81 ? 554 SER A C     1 
ATOM   3877 O  O     . SER A 1 554 ? 100.522 148.181 106.240 1.00 55.81 ? 554 SER A O     1 
ATOM   3878 C  CB    . SER A 1 554 ? 102.379 145.737 105.258 1.00 55.81 ? 554 SER A CB    1 
ATOM   3879 O  OG    . SER A 1 554 ? 103.588 145.723 105.993 1.00 55.81 ? 554 SER A OG    1 
ATOM   3880 N  N     . PRO A 1 555 ? 101.764 147.443 107.961 1.00 58.56 ? 555 PRO A N     1 
ATOM   3881 C  CA    . PRO A 1 555 ? 101.788 148.778 108.581 1.00 58.56 ? 555 PRO A CA    1 
ATOM   3882 C  C     . PRO A 1 555 ? 102.570 149.818 107.793 1.00 58.56 ? 555 PRO A C     1 
ATOM   3883 O  O     . PRO A 1 555 ? 102.398 151.016 108.053 1.00 58.56 ? 555 PRO A O     1 
ATOM   3884 C  CB    . PRO A 1 555 ? 102.429 148.518 109.950 1.00 58.56 ? 555 PRO A CB    1 
ATOM   3885 C  CG    . PRO A 1 555 ? 103.214 147.272 109.773 1.00 58.56 ? 555 PRO A CG    1 
ATOM   3886 C  CD    . PRO A 1 555 ? 102.442 146.437 108.797 1.00 58.56 ? 555 PRO A CD    1 
ATOM   3887 N  N     . SER A 1 556 ? 103.409 149.411 106.846 1.00 59.46 ? 556 SER A N     1 
ATOM   3888 C  CA    . SER A 1 556 ? 104.189 150.344 106.042 1.00 59.46 ? 556 SER A CA    1 
ATOM   3889 C  C     . SER A 1 556 ? 104.339 149.752 104.645 1.00 59.46 ? 556 SER A C     1 
ATOM   3890 O  O     . SER A 1 556 ? 103.570 148.876 104.239 1.00 59.46 ? 556 SER A O     1 
ATOM   3891 C  CB    . SER A 1 556 ? 105.542 150.634 106.701 1.00 59.46 ? 556 SER A CB    1 
ATOM   3892 O  OG    . SER A 1 556 ? 106.481 151.100 105.747 1.00 59.46 ? 556 SER A OG    1 
ATOM   3893 N  N     . ASP A 1 557 ? 105.330 150.243 103.897 1.00 60.98 ? 557 ASP A N     1 
ATOM   3894 C  CA    . ASP A 1 557 ? 105.566 149.767 102.541 1.00 60.98 ? 557 ASP A CA    1 
ATOM   3895 C  C     . ASP A 1 557 ? 107.019 149.379 102.288 1.00 60.98 ? 557 ASP A C     1 
ATOM   3896 O  O     . ASP A 1 557 ? 107.409 149.227 101.125 1.00 60.98 ? 557 ASP A O     1 
ATOM   3897 C  CB    . ASP A 1 557 ? 105.129 150.825 101.521 1.00 60.98 ? 557 ASP A CB    1 
ATOM   3898 C  CG    . ASP A 1 557 ? 103.626 150.845 101.306 1.00 60.98 ? 557 ASP A CG    1 
ATOM   3899 O  OD1   . ASP A 1 557 ? 102.951 149.869 101.693 1.00 60.98 ? 557 ASP A OD1   1 
ATOM   3900 O  OD2   . ASP A 1 557 ? 103.118 151.843 100.752 1.00 60.98 ? 557 ASP A OD2   1 
ATOM   3901 N  N     . SER A 1 558 ? 107.829 149.220 103.332 1.00 55.38 ? 558 SER A N     1 
ATOM   3902 C  CA    . SER A 1 558 ? 109.233 148.893 103.137 1.00 55.38 ? 558 SER A CA    1 
ATOM   3903 C  C     . SER A 1 558 ? 109.392 147.445 102.671 1.00 55.38 ? 558 SER A C     1 
ATOM   3904 O  O     . SER A 1 558 ? 108.528 146.602 102.926 1.00 55.38 ? 558 SER A O     1 
ATOM   3905 C  CB    . SER A 1 558 ? 110.022 149.111 104.426 1.00 55.38 ? 558 SER A CB    1 
ATOM   3906 O  OG    . SER A 1 558 ? 109.527 148.310 105.479 1.00 55.38 ? 558 SER A OG    1 
ATOM   3907 N  N     . PRO A 1 559 ? 110.494 147.130 101.984 1.00 48.17 ? 559 PRO A N     1 
ATOM   3908 C  CA    . PRO A 1 559 ? 110.695 145.750 101.518 1.00 48.17 ? 559 PRO A CA    1 
ATOM   3909 C  C     . PRO A 1 559 ? 111.017 144.767 102.627 1.00 48.17 ? 559 PRO A C     1 
ATOM   3910 O  O     . PRO A 1 559 ? 111.177 143.574 102.344 1.00 48.17 ? 559 PRO A O     1 
ATOM   3911 C  CB    . PRO A 1 559 ? 111.862 145.881 100.532 1.00 48.17 ? 559 PRO A CB    1 
ATOM   3912 C  CG    . PRO A 1 559 ? 112.613 147.072 101.004 1.00 48.17 ? 559 PRO A CG    1 
ATOM   3913 C  CD    . PRO A 1 559 ? 111.581 148.023 101.544 1.00 48.17 ? 559 PRO A CD    1 
ATOM   3914 N  N     . ARG A 1 560 ? 111.141 145.219 103.872 1.00 46.86 ? 560 ARG A N     1 
ATOM   3915 C  CA    . ARG A 1 560 ? 111.338 144.284 104.971 1.00 46.86 ? 560 ARG A CA    1 
ATOM   3916 C  C     . ARG A 1 560 ? 110.076 144.122 105.809 1.00 46.86 ? 560 ARG A C     1 
ATOM   3917 O  O     . ARG A 1 560 ? 109.826 143.044 106.352 1.00 46.86 ? 560 ARG A O     1 
ATOM   3918 C  CB    . ARG A 1 560 ? 112.502 144.731 105.857 1.00 46.86 ? 560 ARG A CB    1 
ATOM   3919 C  CG    . ARG A 1 560 ? 112.899 143.679 106.874 1.00 46.86 ? 560 ARG A CG    1 
ATOM   3920 C  CD    . ARG A 1 560 ? 113.988 144.165 107.803 1.00 46.86 ? 560 ARG A CD    1 
ATOM   3921 N  NE    . ARG A 1 560 ? 114.429 143.104 108.699 1.00 46.86 ? 560 ARG A NE    1 
ATOM   3922 C  CZ    . ARG A 1 560 ? 113.795 142.752 109.808 1.00 46.86 ? 560 ARG A CZ    1 
ATOM   3923 N  NH1   . ARG A 1 560 ? 112.673 143.346 110.180 1.00 46.86 ? 560 ARG A NH1   1 
ATOM   3924 N  NH2   . ARG A 1 560 ? 114.300 141.781 110.562 1.00 46.86 ? 560 ARG A NH2   1 
ATOM   3925 N  N     . CYS A 1 561 ? 109.273 145.180 105.927 1.00 47.15 ? 561 CYS A N     1 
ATOM   3926 C  CA    . CYS A 1 561 ? 108.023 145.084 106.671 1.00 47.15 ? 561 CYS A CA    1 
ATOM   3927 C  C     . CYS A 1 561 ? 107.031 144.130 106.020 1.00 47.15 ? 561 CYS A C     1 
ATOM   3928 O  O     . CYS A 1 561 ? 106.356 143.376 106.731 1.00 47.15 ? 561 CYS A O     1 
ATOM   3929 C  CB    . CYS A 1 561 ? 107.395 146.467 106.814 1.00 47.15 ? 561 CYS A CB    1 
ATOM   3930 S  SG    . CYS A 1 561 ? 105.796 146.473 107.613 1.00 47.15 ? 561 CYS A SG    1 
ATOM   3931 N  N     . MET A 1 562 ? 106.936 144.131 104.689 1.00 44.80 ? 562 MET A N     1 
ATOM   3932 C  CA    . MET A 1 562 ? 105.989 143.270 103.993 1.00 44.80 ? 562 MET A CA    1 
ATOM   3933 C  C     . MET A 1 562 ? 106.443 141.820 103.915 1.00 44.80 ? 562 MET A C     1 
ATOM   3934 O  O     . MET A 1 562 ? 105.838 141.040 103.176 1.00 44.80 ? 562 MET A O     1 
ATOM   3935 C  CB    . MET A 1 562 ? 105.720 143.794 102.580 1.00 44.80 ? 562 MET A CB    1 
ATOM   3936 C  CG    . MET A 1 562 ? 106.917 143.779 101.657 1.00 44.80 ? 562 MET A CG    1 
ATOM   3937 S  SD    . MET A 1 562 ? 106.532 144.501 100.052 1.00 44.80 ? 562 MET A SD    1 
ATOM   3938 C  CE    . MET A 1 562 ? 106.439 146.237 100.466 1.00 44.80 ? 562 MET A CE    1 
ATOM   3939 N  N     . ILE A 1 563 ? 107.485 141.438 104.643 1.00 39.36 ? 563 ILE A N     1 
ATOM   3940 C  CA    . ILE A 1 563 ? 107.848 140.034 104.754 1.00 39.36 ? 563 ILE A CA    1 
ATOM   3941 C  C     . ILE A 1 563 ? 107.245 139.492 106.041 1.00 39.36 ? 563 ILE A C     1 
ATOM   3942 O  O     . ILE A 1 563 ? 106.564 138.459 106.035 1.00 39.36 ? 563 ILE A O     1 
ATOM   3943 C  CB    . ILE A 1 563 ? 109.371 139.839 104.729 1.00 39.36 ? 563 ILE A CB    1 
ATOM   3944 C  CG1   . ILE A 1 563 ? 109.932 140.197 103.350 1.00 39.36 ? 563 ILE A CG1   1 
ATOM   3945 C  CG2   . ILE A 1 563 ? 109.715 138.410 105.095 1.00 39.36 ? 563 ILE A CG2   1 
ATOM   3946 C  CD1   . ILE A 1 563 ? 111.425 140.470 103.340 1.00 39.36 ? 563 ILE A CD1   1 
ATOM   3947 N  N     . GLN A 1 564 ? 107.471 140.191 107.157 1.00 43.31 ? 564 GLN A N     1 
ATOM   3948 C  CA    . GLN A 1 564 ? 106.838 139.774 108.404 1.00 43.31 ? 564 GLN A CA    1 
ATOM   3949 C  C     . GLN A 1 564 ? 105.338 140.033 108.420 1.00 43.31 ? 564 GLN A C     1 
ATOM   3950 O  O     . GLN A 1 564 ? 104.614 139.302 109.103 1.00 43.31 ? 564 GLN A O     1 
ATOM   3951 C  CB    . GLN A 1 564 ? 107.478 140.462 109.608 1.00 43.31 ? 564 GLN A CB    1 
ATOM   3952 C  CG    . GLN A 1 564 ? 107.512 141.964 109.539 1.00 43.31 ? 564 GLN A CG    1 
ATOM   3953 C  CD    . GLN A 1 564 ? 108.878 142.460 109.182 1.00 43.31 ? 564 GLN A CD    1 
ATOM   3954 O  OE1   . GLN A 1 564 ? 109.688 141.717 108.638 1.00 43.31 ? 564 GLN A OE1   1 
ATOM   3955 N  NE2   . GLN A 1 564 ? 109.159 143.711 109.504 1.00 43.31 ? 564 GLN A NE2   1 
ATOM   3956 N  N     . SER A 1 565 ? 104.849 141.029 107.680 1.00 44.11 ? 565 SER A N     1 
ATOM   3957 C  CA    . SER A 1 565 ? 103.406 141.189 107.570 1.00 44.11 ? 565 SER A CA    1 
ATOM   3958 C  C     . SER A 1 565 ? 102.755 140.023 106.842 1.00 44.11 ? 565 SER A C     1 
ATOM   3959 O  O     . SER A 1 565 ? 101.527 139.897 106.875 1.00 44.11 ? 565 SER A O     1 
ATOM   3960 C  CB    . SER A 1 565 ? 103.066 142.499 106.867 1.00 44.11 ? 565 SER A CB    1 
ATOM   3961 O  OG    . SER A 1 565 ? 103.553 143.607 107.601 1.00 44.11 ? 565 SER A OG    1 
ATOM   3962 N  N     . ARG A 1 566 ? 103.542 139.177 106.179 1.00 40.58 ? 566 ARG A N     1 
ATOM   3963 C  CA    . ARG A 1 566 ? 103.029 137.965 105.553 1.00 40.58 ? 566 ARG A CA    1 
ATOM   3964 C  C     . ARG A 1 566 ? 103.316 136.733 106.407 1.00 40.58 ? 566 ARG A C     1 
ATOM   3965 O  O     . ARG A 1 566 ? 102.546 135.761 106.386 1.00 40.58 ? 566 ARG A O     1 
ATOM   3966 C  CB    . ARG A 1 566 ? 103.629 137.810 104.151 1.00 40.58 ? 566 ARG A CB    1 
ATOM   3967 C  CG    . ARG A 1 566 ? 103.080 136.639 103.362 1.00 40.58 ? 566 ARG A CG    1 
ATOM   3968 C  CD    . ARG A 1 566 ? 101.718 136.935 102.776 1.00 40.58 ? 566 ARG A CD    1 
ATOM   3969 N  NE    . ARG A 1 566 ? 101.792 137.525 101.445 1.00 40.58 ? 566 ARG A NE    1 
ATOM   3970 C  CZ    . ARG A 1 566 ? 101.745 136.830 100.317 1.00 40.58 ? 566 ARG A CZ    1 
ATOM   3971 N  NH1   . ARG A 1 566 ? 101.649 135.512 100.321 1.00 40.58 ? 566 ARG A NH1   1 
ATOM   3972 N  NH2   . ARG A 1 566 ? 101.783 137.475 99.155  1.00 40.58 ? 566 ARG A NH2   1 
ATOM   3973 N  N     . ILE A 1 567 ? 104.412 136.764 107.165 1.00 32.85 ? 567 ILE A N     1 
ATOM   3974 C  CA    . ILE A 1 567 ? 104.635 135.734 108.179 1.00 32.85 ? 567 ILE A CA    1 
ATOM   3975 C  C     . ILE A 1 567 ? 103.485 135.724 109.181 1.00 32.85 ? 567 ILE A C     1 
ATOM   3976 O  O     . ILE A 1 567 ? 103.016 134.660 109.611 1.00 32.85 ? 567 ILE A O     1 
ATOM   3977 C  CB    . ILE A 1 567 ? 105.986 135.948 108.886 1.00 32.85 ? 567 ILE A CB    1 
ATOM   3978 C  CG1   . ILE A 1 567 ? 107.114 136.129 107.873 1.00 32.85 ? 567 ILE A CG1   1 
ATOM   3979 C  CG2   . ILE A 1 567 ? 106.296 134.769 109.791 1.00 32.85 ? 567 ILE A CG2   1 
ATOM   3980 C  CD1   . ILE A 1 567 ? 108.480 136.244 108.493 1.00 32.85 ? 567 ILE A CD1   1 
ATOM   3981 N  N     . ALA A 1 568 ? 103.011 136.910 109.566 1.00 30.11 ? 568 ALA A N     1 
ATOM   3982 C  CA    . ALA A 1 568 ? 101.922 137.033 110.524 1.00 30.11 ? 568 ALA A CA    1 
ATOM   3983 C  C     . ALA A 1 568 ? 100.576 136.581 109.971 1.00 30.11 ? 568 ALA A C     1 
ATOM   3984 O  O     . ALA A 1 568 ? 99.632  136.427 110.751 1.00 30.11 ? 568 ALA A O     1 
ATOM   3985 C  CB    . ALA A 1 568 ? 101.814 138.478 111.013 1.00 30.11 ? 568 ALA A CB    1 
ATOM   3986 N  N     . ASP A 1 569 ? 100.450 136.384 108.661 1.00 27.30 ? 569 ASP A N     1 
ATOM   3987 C  CA    . ASP A 1 569 ? 99.236  135.813 108.090 1.00 27.30 ? 569 ASP A CA    1 
ATOM   3988 C  C     . ASP A 1 569 ? 99.341  134.309 107.895 1.00 27.30 ? 569 ASP A C     1 
ATOM   3989 O  O     . ASP A 1 569 ? 98.372  133.575 108.150 1.00 27.30 ? 569 ASP A O     1 
ATOM   3990 C  CB    . ASP A 1 569 ? 98.912  136.481 106.750 1.00 27.30 ? 569 ASP A CB    1 
ATOM   3991 C  CG    . ASP A 1 569 ? 97.423  136.525 106.466 1.00 27.30 ? 569 ASP A CG    1 
ATOM   3992 O  OD1   . ASP A 1 569 ? 96.632  136.233 107.387 1.00 27.30 ? 569 ASP A OD1   1 
ATOM   3993 O  OD2   . ASP A 1 569 ? 97.042  136.848 105.322 1.00 27.30 ? 569 ASP A OD2   1 
ATOM   3994 N  N     . THR A 1 570 ? 100.506 133.834 107.458 1.00 22.50 ? 570 THR A N     1 
ATOM   3995 C  CA    . THR A 1 570 ? 100.715 132.395 107.380 1.00 22.50 ? 570 THR A CA    1 
ATOM   3996 C  C     . THR A 1 570 ? 100.577 131.746 108.750 1.00 22.50 ? 570 THR A C     1 
ATOM   3997 O  O     . THR A 1 570 ? 100.005 130.654 108.872 1.00 22.50 ? 570 THR A O     1 
ATOM   3998 C  CB    . THR A 1 570 ? 102.084 132.092 106.780 1.00 22.50 ? 570 THR A CB    1 
ATOM   3999 O  OG1   . THR A 1 570 ? 102.156 132.634 105.457 1.00 22.50 ? 570 THR A OG1   1 
ATOM   4000 C  CG2   . THR A 1 570 ? 102.314 130.602 106.726 1.00 22.50 ? 570 THR A CG2   1 
ATOM   4001 N  N     . SER A 1 571 ? 101.079 132.410 109.796 1.00 21.63 ? 571 SER A N     1 
ATOM   4002 C  CA    . SER A 1 571 ? 100.948 131.864 111.143 1.00 21.63 ? 571 SER A CA    1 
ATOM   4003 C  C     . SER A 1 571 ? 99.490  131.705 111.552 1.00 21.63 ? 571 SER A C     1 
ATOM   4004 O  O     . SER A 1 571 ? 99.106  130.655 112.078 1.00 21.63 ? 571 SER A O     1 
ATOM   4005 C  CB    . SER A 1 571 ? 101.676 132.763 112.139 1.00 21.63 ? 571 SER A CB    1 
ATOM   4006 O  OG    . SER A 1 571 ? 103.061 132.811 111.859 1.00 21.63 ? 571 SER A OG    1 
ATOM   4007 N  N     . ARG A 1 572 ? 98.665  132.722 111.307 1.00 20.57 ? 572 ARG A N     1 
ATOM   4008 C  CA    . ARG A 1 572 ? 97.264  132.655 111.700 1.00 20.57 ? 572 ARG A CA    1 
ATOM   4009 C  C     . ARG A 1 572 ? 96.515  131.584 110.921 1.00 20.57 ? 572 ARG A C     1 
ATOM   4010 O  O     . ARG A 1 572 ? 95.697  130.854 111.495 1.00 20.57 ? 572 ARG A O     1 
ATOM   4011 C  CB    . ARG A 1 572 ? 96.607  134.017 111.507 1.00 20.57 ? 572 ARG A CB    1 
ATOM   4012 C  CG    . ARG A 1 572 ? 97.059  135.053 112.516 1.00 20.57 ? 572 ARG A CG    1 
ATOM   4013 C  CD    . ARG A 1 572 ? 96.126  136.247 112.541 1.00 20.57 ? 572 ARG A CD    1 
ATOM   4014 N  NE    . ARG A 1 572 ? 96.046  136.906 111.243 1.00 20.57 ? 572 ARG A NE    1 
ATOM   4015 C  CZ    . ARG A 1 572 ? 96.908  137.815 110.809 1.00 20.57 ? 572 ARG A CZ    1 
ATOM   4016 N  NH1   . ARG A 1 572 ? 97.937  138.199 111.546 1.00 20.57 ? 572 ARG A NH1   1 
ATOM   4017 N  NH2   . ARG A 1 572 ? 96.732  138.353 109.606 1.00 20.57 ? 572 ARG A NH2   1 
ATOM   4018 N  N     . ARG A 1 573 ? 96.772  131.471 109.613 1.00 20.04 ? 573 ARG A N     1 
ATOM   4019 C  CA    . ARG A 1 573 ? 96.103  130.429 108.834 1.00 20.04 ? 573 ARG A CA    1 
ATOM   4020 C  C     . ARG A 1 573 ? 96.476  129.035 109.330 1.00 20.04 ? 573 ARG A C     1 
ATOM   4021 O  O     . ARG A 1 573 ? 95.599  128.178 109.534 1.00 20.04 ? 573 ARG A O     1 
ATOM   4022 C  CB    . ARG A 1 573 ? 96.440  130.584 107.353 1.00 20.04 ? 573 ARG A CB    1 
ATOM   4023 C  CG    . ARG A 1 573 ? 95.854  131.832 106.721 1.00 20.04 ? 573 ARG A CG    1 
ATOM   4024 C  CD    . ARG A 1 573 ? 96.749  132.382 105.630 1.00 20.04 ? 573 ARG A CD    1 
ATOM   4025 N  NE    . ARG A 1 573 ? 96.532  131.728 104.346 1.00 20.04 ? 573 ARG A NE    1 
ATOM   4026 C  CZ    . ARG A 1 573 ? 97.024  132.165 103.194 1.00 20.04 ? 573 ARG A CZ    1 
ATOM   4027 N  NH1   . ARG A 1 573 ? 97.757  133.263 103.128 1.00 20.04 ? 573 ARG A NH1   1 
ATOM   4028 N  NH2   . ARG A 1 573 ? 96.773  131.482 102.081 1.00 20.04 ? 573 ARG A NH2   1 
ATOM   4029 N  N     . LEU A 1 574 ? 97.768  128.794 109.555 1.00 17.01 ? 574 LEU A N     1 
ATOM   4030 C  CA    . LEU A 1 574 ? 98.189  127.483 110.029 1.00 17.01 ? 574 LEU A CA    1 
ATOM   4031 C  C     . LEU A 1 574 ? 97.624  127.189 111.412 1.00 17.01 ? 574 LEU A C     1 
ATOM   4032 O  O     . LEU A 1 574 ? 97.250  126.050 111.704 1.00 17.01 ? 574 LEU A O     1 
ATOM   4033 C  CB    . LEU A 1 574 ? 99.713  127.395 110.035 1.00 17.01 ? 574 LEU A CB    1 
ATOM   4034 C  CG    . LEU A 1 574 ? 100.309 126.036 110.388 1.00 17.01 ? 574 LEU A CG    1 
ATOM   4035 C  CD1   . LEU A 1 574 ? 99.898  125.004 109.364 1.00 17.01 ? 574 LEU A CD1   1 
ATOM   4036 C  CD2   . LEU A 1 574 ? 101.811 126.131 110.466 1.00 17.01 ? 574 LEU A CD2   1 
ATOM   4037 N  N     . ASN A 1 575 ? 97.541  128.207 112.277 1.00 18.78 ? 575 ASN A N     1 
ATOM   4038 C  CA    . ASN A 1 575 ? 97.014  127.994 113.623 1.00 18.78 ? 575 ASN A CA    1 
ATOM   4039 C  C     . ASN A 1 575 ? 95.521  127.688 113.611 1.00 18.78 ? 575 ASN A C     1 
ATOM   4040 O  O     . ASN A 1 575 ? 95.055  126.841 114.387 1.00 18.78 ? 575 ASN A O     1 
ATOM   4041 C  CB    . ASN A 1 575 ? 97.300  129.217 114.491 1.00 18.78 ? 575 ASN A CB    1 
ATOM   4042 C  CG    . ASN A 1 575 ? 98.675  129.173 115.120 1.00 18.78 ? 575 ASN A CG    1 
ATOM   4043 O  OD1   . ASN A 1 575 ? 99.350  128.148 115.093 1.00 18.78 ? 575 ASN A OD1   1 
ATOM   4044 N  ND2   . ASN A 1 575 ? 99.103  130.293 115.682 1.00 18.78 ? 575 ASN A ND2   1 
ATOM   4045 N  N     . SER A 1 576 ? 94.757  128.361 112.748 1.00 14.56 ? 576 SER A N     1 
ATOM   4046 C  CA    . SER A 1 576 ? 93.341  128.035 112.622 1.00 14.56 ? 576 SER A CA    1 
ATOM   4047 C  C     . SER A 1 576 ? 93.150  126.605 112.136 1.00 14.56 ? 576 SER A C     1 
ATOM   4048 O  O     . SER A 1 576 ? 92.293  125.876 112.656 1.00 14.56 ? 576 SER A O     1 
ATOM   4049 C  CB    . SER A 1 576 ? 92.653  129.017 111.678 1.00 14.56 ? 576 SER A CB    1 
ATOM   4050 O  OG    . SER A 1 576 ? 93.148  128.893 110.357 1.00 14.56 ? 576 SER A OG    1 
ATOM   4051 N  N     . PHE A 1 577 ? 93.946  126.179 111.149 1.00 16.85 ? 577 PHE A N     1 
ATOM   4052 C  CA    . PHE A 1 577 ? 93.883  124.777 110.742 1.00 16.85 ? 577 PHE A CA    1 
ATOM   4053 C  C     . PHE A 1 577 ? 94.228  123.834 111.884 1.00 16.85 ? 577 PHE A C     1 
ATOM   4054 O  O     . PHE A 1 577 ? 93.553  122.813 112.056 1.00 16.85 ? 577 PHE A O     1 
ATOM   4055 C  CB    . PHE A 1 577 ? 94.825  124.506 109.568 1.00 16.85 ? 577 PHE A CB    1 
ATOM   4056 C  CG    . PHE A 1 577 ? 94.281  124.932 108.238 1.00 16.85 ? 577 PHE A CG    1 
ATOM   4057 C  CD1   . PHE A 1 577 ? 93.070  124.451 107.786 1.00 16.85 ? 577 PHE A CD1   1 
ATOM   4058 C  CD2   . PHE A 1 577 ? 94.993  125.799 107.432 1.00 16.85 ? 577 PHE A CD2   1 
ATOM   4059 C  CE1   . PHE A 1 577 ? 92.573  124.839 106.563 1.00 16.85 ? 577 PHE A CE1   1 
ATOM   4060 C  CE2   . PHE A 1 577 ? 94.500  126.189 106.209 1.00 16.85 ? 577 PHE A CE2   1 
ATOM   4061 C  CZ    . PHE A 1 577 ? 93.289  125.709 105.774 1.00 16.85 ? 577 PHE A CZ    1 
ATOM   4062 N  N     . LYS A 1 578 ? 95.258  124.159 112.666 1.00 19.03 ? 578 LYS A N     1 
ATOM   4063 C  CA    . LYS A 1 578 ? 95.690  123.286 113.751 1.00 19.03 ? 578 LYS A CA    1 
ATOM   4064 C  C     . LYS A 1 578 ? 94.600  123.116 114.798 1.00 19.03 ? 578 LYS A C     1 
ATOM   4065 O  O     . LYS A 1 578 ? 94.402  122.014 115.321 1.00 19.03 ? 578 LYS A O     1 
ATOM   4066 C  CB    . LYS A 1 578 ? 96.961  123.841 114.389 1.00 19.03 ? 578 LYS A CB    1 
ATOM   4067 C  CG    . LYS A 1 578 ? 98.191  123.703 113.524 1.00 19.03 ? 578 LYS A CG    1 
ATOM   4068 C  CD    . LYS A 1 578 ? 99.384  124.358 114.164 1.00 19.03 ? 578 LYS A CD    1 
ATOM   4069 C  CE    . LYS A 1 578 ? 100.052 123.422 115.138 1.00 19.03 ? 578 LYS A CE    1 
ATOM   4070 N  NZ    . LYS A 1 578 ? 101.343 123.975 115.611 1.00 19.03 ? 578 LYS A NZ    1 
ATOM   4071 N  N     . TYR A 1 579 ? 93.900  124.196 115.139 1.00 21.24 ? 579 TYR A N     1 
ATOM   4072 C  CA    . TYR A 1 579 ? 92.812  124.067 116.104 1.00 21.24 ? 579 TYR A CA    1 
ATOM   4073 C  C     . TYR A 1 579 ? 91.647  123.275 115.524 1.00 21.24 ? 579 TYR A C     1 
ATOM   4074 O  O     . TYR A 1 579 ? 91.154  122.327 116.156 1.00 21.24 ? 579 TYR A O     1 
ATOM   4075 C  CB    . TYR A 1 579 ? 92.341  125.446 116.555 1.00 21.24 ? 579 TYR A CB    1 
ATOM   4076 C  CG    . TYR A 1 579 ? 91.153  125.419 117.489 1.00 21.24 ? 579 TYR A CG    1 
ATOM   4077 C  CD1   . TYR A 1 579 ? 91.190  124.696 118.673 1.00 21.24 ? 579 TYR A CD1   1 
ATOM   4078 C  CD2   . TYR A 1 579 ? 89.998  126.123 117.192 1.00 21.24 ? 579 TYR A CD2   1 
ATOM   4079 C  CE1   . TYR A 1 579 ? 90.109  124.675 119.529 1.00 21.24 ? 579 TYR A CE1   1 
ATOM   4080 C  CE2   . TYR A 1 579 ? 88.914  126.106 118.040 1.00 21.24 ? 579 TYR A CE2   1 
ATOM   4081 C  CZ    . TYR A 1 579 ? 88.974  125.383 119.206 1.00 21.24 ? 579 TYR A CZ    1 
ATOM   4082 O  OH    . TYR A 1 579 ? 87.890  125.371 120.052 1.00 21.24 ? 579 TYR A OH    1 
ATOM   4083 N  N     . GLN A 1 580 ? 91.198  123.639 114.318 1.00 17.43 ? 580 GLN A N     1 
ATOM   4084 C  CA    . GLN A 1 580 ? 89.979  123.044 113.783 1.00 17.43 ? 580 GLN A CA    1 
ATOM   4085 C  C     . GLN A 1 580 ? 90.147  121.556 113.511 1.00 17.43 ? 580 GLN A C     1 
ATOM   4086 O  O     . GLN A 1 580 ? 89.210  120.778 113.716 1.00 17.43 ? 580 GLN A O     1 
ATOM   4087 C  CB    . GLN A 1 580 ? 89.544  123.776 112.517 1.00 17.43 ? 580 GLN A CB    1 
ATOM   4088 C  CG    . GLN A 1 580 ? 88.651  124.972 112.787 1.00 17.43 ? 580 GLN A CG    1 
ATOM   4089 C  CD    . GLN A 1 580 ? 87.491  124.636 113.706 1.00 17.43 ? 580 GLN A CD    1 
ATOM   4090 O  OE1   . GLN A 1 580 ? 87.329  125.238 114.767 1.00 17.43 ? 580 GLN A OE1   1 
ATOM   4091 N  NE2   . GLN A 1 580 ? 86.678  123.668 113.303 1.00 17.43 ? 580 GLN A NE2   1 
ATOM   4092 N  N     . MET A 1 581 ? 91.320  121.133 113.040 1.00 17.60 ? 581 MET A N     1 
ATOM   4093 C  CA    . MET A 1 581 ? 91.499  119.712 112.780 1.00 17.60 ? 581 MET A CA    1 
ATOM   4094 C  C     . MET A 1 581 ? 91.753  118.906 114.042 1.00 17.60 ? 581 MET A C     1 
ATOM   4095 O  O     . MET A 1 581 ? 91.567  117.688 114.019 1.00 17.60 ? 581 MET A O     1 
ATOM   4096 C  CB    . MET A 1 581 ? 92.642  119.500 111.793 1.00 17.60 ? 581 MET A CB    1 
ATOM   4097 C  CG    . MET A 1 581 ? 92.260  119.764 110.352 1.00 17.60 ? 581 MET A CG    1 
ATOM   4098 S  SD    . MET A 1 581 ? 93.675  119.653 109.256 1.00 17.60 ? 581 MET A SD    1 
ATOM   4099 C  CE    . MET A 1 581 ? 94.054  117.919 109.441 1.00 17.60 ? 581 MET A CE    1 
ATOM   4100 N  N     . ASN A 1 582 ? 92.179  119.542 115.130 1.00 22.51 ? 582 ASN A N     1 
ATOM   4101 C  CA    . ASN A 1 582 ? 92.351  118.846 116.400 1.00 22.51 ? 582 ASN A CA    1 
ATOM   4102 C  C     . ASN A 1 582 ? 91.044  118.686 117.156 1.00 22.51 ? 582 ASN A C     1 
ATOM   4103 O  O     . ASN A 1 582 ? 90.880  117.711 117.897 1.00 22.51 ? 582 ASN A O     1 
ATOM   4104 C  CB    . ASN A 1 582 ? 93.356  119.586 117.284 1.00 22.51 ? 582 ASN A CB    1 
ATOM   4105 C  CG    . ASN A 1 582 ? 93.433  119.013 118.683 1.00 22.51 ? 582 ASN A CG    1 
ATOM   4106 O  OD1   . ASN A 1 582 ? 92.765  119.492 119.597 1.00 22.51 ? 582 ASN A OD1   1 
ATOM   4107 N  ND2   . ASN A 1 582 ? 94.244  117.980 118.856 1.00 22.51 ? 582 ASN A ND2   1 
ATOM   4108 N  N     . LYS A 1 583 ? 90.110  119.623 116.987 1.00 19.71 ? 583 LYS A N     1 
ATOM   4109 C  CA    . LYS A 1 583 ? 88.799  119.466 117.606 1.00 19.71 ? 583 LYS A CA    1 
ATOM   4110 C  C     . LYS A 1 583 ? 88.105  118.181 117.180 1.00 19.71 ? 583 LYS A C     1 
ATOM   4111 O  O     . LYS A 1 583 ? 87.280  117.659 117.934 1.00 19.71 ? 583 LYS A O     1 
ATOM   4112 C  CB    . LYS A 1 583 ? 87.915  120.661 117.265 1.00 19.71 ? 583 LYS A CB    1 
ATOM   4113 C  CG    . LYS A 1 583 ? 86.679  120.781 118.119 1.00 19.71 ? 583 LYS A CG    1 
ATOM   4114 C  CD    . LYS A 1 583 ? 86.123  122.188 118.071 1.00 19.71 ? 583 LYS A CD    1 
ATOM   4115 C  CE    . LYS A 1 583 ? 84.745  122.255 118.696 1.00 19.71 ? 583 LYS A CE    1 
ATOM   4116 N  NZ    . LYS A 1 583 ? 84.511  123.564 119.361 1.00 19.71 ? 583 LYS A NZ    1 
ATOM   4117 N  N     . GLU A 1 584 ? 88.421  117.660 115.995 1.00 20.80 ? 584 GLU A N     1 
ATOM   4118 C  CA    . GLU A 1 584 ? 87.753  116.493 115.432 1.00 20.80 ? 584 GLU A CA    1 
ATOM   4119 C  C     . GLU A 1 584 ? 88.525  115.198 115.637 1.00 20.80 ? 584 GLU A C     1 
ATOM   4120 O  O     . GLU A 1 584 ? 88.048  114.139 115.224 1.00 20.80 ? 584 GLU A O     1 
ATOM   4121 C  CB    . GLU A 1 584 ? 87.516  116.705 113.937 1.00 20.80 ? 584 GLU A CB    1 
ATOM   4122 C  CG    . GLU A 1 584 ? 86.719  117.948 113.613 1.00 20.80 ? 584 GLU A CG    1 
ATOM   4123 C  CD    . GLU A 1 584 ? 86.724  118.265 112.136 1.00 20.80 ? 584 GLU A CD    1 
ATOM   4124 O  OE1   . GLU A 1 584 ? 87.411  117.550 111.378 1.00 20.80 ? 584 GLU A OE1   1 
ATOM   4125 O  OE2   . GLU A 1 584 ? 86.050  119.234 111.731 1.00 20.80 ? 584 GLU A OE2   1 
ATOM   4126 N  N     . GLY A 1 585 ? 89.697  115.251 116.258 1.00 19.82 ? 585 GLY A N     1 
ATOM   4127 C  CA    . GLY A 1 585 ? 90.494  114.052 116.430 1.00 19.82 ? 585 GLY A CA    1 
ATOM   4128 C  C     . GLY A 1 585 ? 91.229  113.609 115.187 1.00 19.82 ? 585 GLY A C     1 
ATOM   4129 O  O     . GLY A 1 585 ? 91.608  112.439 115.089 1.00 19.82 ? 585 GLY A O     1 
ATOM   4130 N  N     . TYR A 1 586 ? 91.446  114.518 114.233 1.00 21.18 ? 586 TYR A N     1 
ATOM   4131 C  CA    . TYR A 1 586 ? 92.164  114.231 112.988 1.00 21.18 ? 586 TYR A CA    1 
ATOM   4132 C  C     . TYR A 1 586 ? 91.491  113.097 112.211 1.00 21.18 ? 586 TYR A C     1 
ATOM   4133 O  O     . TYR A 1 586 ? 92.056  112.020 112.017 1.00 21.18 ? 586 TYR A O     1 
ATOM   4134 C  CB    . TYR A 1 586 ? 93.637  113.906 113.259 1.00 21.18 ? 586 TYR A CB    1 
ATOM   4135 C  CG    . TYR A 1 586 ? 94.379  114.956 114.050 1.00 21.18 ? 586 TYR A CG    1 
ATOM   4136 C  CD1   . TYR A 1 586 ? 94.480  116.258 113.591 1.00 21.18 ? 586 TYR A CD1   1 
ATOM   4137 C  CD2   . TYR A 1 586 ? 94.979  114.642 115.257 1.00 21.18 ? 586 TYR A CD2   1 
ATOM   4138 C  CE1   . TYR A 1 586 ? 95.155  117.212 114.313 1.00 21.18 ? 586 TYR A CE1   1 
ATOM   4139 C  CE2   . TYR A 1 586 ? 95.655  115.590 115.985 1.00 21.18 ? 586 TYR A CE2   1 
ATOM   4140 C  CZ    . TYR A 1 586 ? 95.741  116.872 115.509 1.00 21.18 ? 586 TYR A CZ    1 
ATOM   4141 O  OH    . TYR A 1 586 ? 96.417  117.821 116.235 1.00 21.18 ? 586 TYR A OH    1 
ATOM   4142 N  N     . GLN A 1 587 ? 90.264  113.363 111.761 1.00 25.68 ? 587 GLN A N     1 
ATOM   4143 C  CA    . GLN A 1 587 ? 89.471  112.316 111.123 1.00 25.68 ? 587 GLN A CA    1 
ATOM   4144 C  C     . GLN A 1 587 ? 90.114  111.844 109.824 1.00 25.68 ? 587 GLN A C     1 
ATOM   4145 O  O     . GLN A 1 587 ? 90.513  110.680 109.704 1.00 25.68 ? 587 GLN A O     1 
ATOM   4146 C  CB    . GLN A 1 587 ? 88.048  112.813 110.869 1.00 25.68 ? 587 GLN A CB    1 
ATOM   4147 C  CG    . GLN A 1 587 ? 87.231  113.021 112.129 1.00 25.68 ? 587 GLN A CG    1 
ATOM   4148 C  CD    . GLN A 1 587 ? 86.972  111.736 112.881 1.00 25.68 ? 587 GLN A CD    1 
ATOM   4149 O  OE1   . GLN A 1 587 ? 87.108  110.643 112.336 1.00 25.68 ? 587 GLN A OE1   1 
ATOM   4150 N  NE2   . GLN A 1 587 ? 86.602  111.860 114.148 1.00 25.68 ? 587 GLN A NE2   1 
ATOM   4151 N  N     . ASP A 1 588 ? 90.230  112.732 108.842 1.00 27.26 ? 588 ASP A N     1 
ATOM   4152 C  CA    . ASP A 1 588 ? 90.841  112.370 107.572 1.00 27.26 ? 588 ASP A CA    1 
ATOM   4153 C  C     . ASP A 1 588 ? 92.355  112.303 107.709 1.00 27.26 ? 588 ASP A C     1 
ATOM   4154 O  O     . ASP A 1 588 ? 92.958  113.044 108.487 1.00 27.26 ? 588 ASP A O     1 
ATOM   4155 C  CB    . ASP A 1 588 ? 90.455  113.368 106.484 1.00 27.26 ? 588 ASP A CB    1 
ATOM   4156 C  CG    . ASP A 1 588 ? 90.395  112.732 105.111 1.00 27.26 ? 588 ASP A CG    1 
ATOM   4157 O  OD1   . ASP A 1 588 ? 91.165  111.784 104.858 1.00 27.26 ? 588 ASP A OD1   1 
ATOM   4158 O  OD2   . ASP A 1 588 ? 89.578  113.178 104.282 1.00 27.26 ? 588 ASP A OD2   1 
ATOM   4159 N  N     . LEU A 1 589 ? 92.967  111.410 106.935 1.00 19.82 ? 589 LEU A N     1 
ATOM   4160 C  CA    . LEU A 1 589 ? 94.389  111.109 107.059 1.00 19.82 ? 589 LEU A CA    1 
ATOM   4161 C  C     . LEU A 1 589 ? 95.220  111.854 106.016 1.00 19.82 ? 589 LEU A C     1 
ATOM   4162 O  O     . LEU A 1 589 ? 96.194  112.539 106.352 1.00 19.82 ? 589 LEU A O     1 
ATOM   4163 C  CB    . LEU A 1 589 ? 94.583  109.597 106.946 1.00 19.82 ? 589 LEU A CB    1 
ATOM   4164 C  CG    . LEU A 1 589 ? 95.933  108.992 107.286 1.00 19.82 ? 589 LEU A CG    1 
ATOM   4165 C  CD1   . LEU A 1 589 ? 96.368  109.418 108.670 1.00 19.82 ? 589 LEU A CD1   1 
ATOM   4166 C  CD2   . LEU A 1 589 ? 95.795  107.492 107.205 1.00 19.82 ? 589 LEU A CD2   1 
ATOM   4167 N  N     . ALA A 1 590 ? 94.840  111.734 104.744 1.00 19.17 ? 590 ALA A N     1 
ATOM   4168 C  CA    . ALA A 1 590 ? 95.503  112.496 103.696 1.00 19.17 ? 590 ALA A CA    1 
ATOM   4169 C  C     . ALA A 1 590 ? 95.312  113.991 103.879 1.00 19.17 ? 590 ALA A C     1 
ATOM   4170 O  O     . ALA A 1 590 ? 96.021  114.779 103.248 1.00 19.17 ? 590 ALA A O     1 
ATOM   4171 C  CB    . ALA A 1 590 ? 94.982  112.073 102.324 1.00 19.17 ? 590 ALA A CB    1 
ATOM   4172 N  N     . GLU A 1 591 ? 94.356  114.393 104.711 1.00 20.73 ? 591 GLU A N     1 
ATOM   4173 C  CA    . GLU A 1 591 ? 94.147  115.802 105.012 1.00 20.73 ? 591 GLU A CA    1 
ATOM   4174 C  C     . GLU A 1 591 ? 95.073  116.286 106.122 1.00 20.73 ? 591 GLU A C     1 
ATOM   4175 O  O     . GLU A 1 591 ? 95.389  117.477 106.182 1.00 20.73 ? 591 GLU A O     1 
ATOM   4176 C  CB    . GLU A 1 591 ? 92.679  116.016 105.371 1.00 20.73 ? 591 GLU A CB    1 
ATOM   4177 C  CG    . GLU A 1 591 ? 92.296  117.404 105.781 1.00 20.73 ? 591 GLU A CG    1 
ATOM   4178 C  CD    . GLU A 1 591 ? 90.841  117.479 106.171 1.00 20.73 ? 591 GLU A CD    1 
ATOM   4179 O  OE1   . GLU A 1 591 ? 90.074  116.590 105.755 1.00 20.73 ? 591 GLU A OE1   1 
ATOM   4180 O  OE2   . GLU A 1 591 ? 90.464  118.416 106.899 1.00 20.73 ? 591 GLU A OE2   1 
ATOM   4181 N  N     . ALA A 1 592 ? 95.526  115.383 106.994 1.00 17.84 ? 592 ALA A N     1 
ATOM   4182 C  CA    . ALA A 1 592 ? 96.501  115.742 108.017 1.00 17.84 ? 592 ALA A CA    1 
ATOM   4183 C  C     . ALA A 1 592 ? 97.929  115.646 107.502 1.00 17.84 ? 592 ALA A C     1 
ATOM   4184 O  O     . ALA A 1 592 ? 98.815  116.373 107.978 1.00 17.84 ? 592 ALA A O     1 
ATOM   4185 C  CB    . ALA A 1 592 ? 96.325  114.847 109.242 1.00 17.84 ? 592 ALA A CB    1 
ATOM   4186 N  N     . LEU A 1 593 ? 98.175  114.758 106.538 1.00 14.15 ? 593 LEU A N     1 
ATOM   4187 C  CA    . LEU A 1 593 ? 99.502  114.682 105.941 1.00 14.15 ? 593 LEU A CA    1 
ATOM   4188 C  C     . LEU A 1 593 ? 99.873  115.958 105.197 1.00 14.15 ? 593 LEU A C     1 
ATOM   4189 O  O     . LEU A 1 593 ? 101.062 116.248 105.046 1.00 14.15 ? 593 LEU A O     1 
ATOM   4190 C  CB    . LEU A 1 593 ? 99.579  113.479 105.009 1.00 14.15 ? 593 LEU A CB    1 
ATOM   4191 C  CG    . LEU A 1 593 ? 99.609  112.145 105.745 1.00 14.15 ? 593 LEU A CG    1 
ATOM   4192 C  CD1   . LEU A 1 593 ? 99.733  111.011 104.765 1.00 14.15 ? 593 LEU A CD1   1 
ATOM   4193 C  CD2   . LEU A 1 593 ? 100.752 112.123 106.724 1.00 14.15 ? 593 LEU A CD2   1 
ATOM   4194 N  N     . ARG A 1 594 ? 98.886  116.721 104.730 1.00 16.34 ? 594 ARG A N     1 
ATOM   4195 C  CA    . ARG A 1 594 ? 99.158  118.018 104.122 1.00 16.34 ? 594 ARG A CA    1 
ATOM   4196 C  C     . ARG A 1 594 ? 99.511  119.068 105.170 1.00 16.34 ? 594 ARG A C     1 
ATOM   4197 O  O     . ARG A 1 594 ? 100.401 119.902 104.945 1.00 16.34 ? 594 ARG A O     1 
ATOM   4198 C  CB    . ARG A 1 594 ? 97.944  118.465 103.315 1.00 16.34 ? 594 ARG A CB    1 
ATOM   4199 C  CG    . ARG A 1 594 ? 97.635  117.613 102.104 1.00 16.34 ? 594 ARG A CG    1 
ATOM   4200 C  CD    . ARG A 1 594 ? 98.614  117.878 100.984 1.00 16.34 ? 594 ARG A CD    1 
ATOM   4201 N  NE    . ARG A 1 594 ? 98.255  117.159 99.769  1.00 16.34 ? 594 ARG A NE    1 
ATOM   4202 C  CZ    . ARG A 1 594 ? 98.912  117.255 98.623  1.00 16.34 ? 594 ARG A CZ    1 
ATOM   4203 N  NH1   . ARG A 1 594 ? 99.973  118.031 98.498  1.00 16.34 ? 594 ARG A NH1   1 
ATOM   4204 N  NH2   . ARG A 1 594 ? 98.490  116.557 97.574  1.00 16.34 ? 594 ARG A NH2   1 
ATOM   4205 N  N     . LEU A 1 595 ? 98.816  119.050 106.310 1.00 14.92 ? 595 LEU A N     1 
ATOM   4206 C  CA    . LEU A 1 595 ? 99.150  119.946 107.410 1.00 14.92 ? 595 LEU A CA    1 
ATOM   4207 C  C     . LEU A 1 595 ? 100.563 119.700 107.912 1.00 14.92 ? 595 LEU A C     1 
ATOM   4208 O  O     . LEU A 1 595 ? 101.259 120.648 108.299 1.00 14.92 ? 595 LEU A O     1 
ATOM   4209 C  CB    . LEU A 1 595 ? 98.144  119.770 108.545 1.00 14.92 ? 595 LEU A CB    1 
ATOM   4210 C  CG    . LEU A 1 595 ? 98.135  120.799 109.674 1.00 14.92 ? 595 LEU A CG    1 
ATOM   4211 C  CD1   . LEU A 1 595 ? 97.526  122.092 109.201 1.00 14.92 ? 595 LEU A CD1   1 
ATOM   4212 C  CD2   . LEU A 1 595 ? 97.376  120.268 110.868 1.00 14.92 ? 595 LEU A CD2   1 
ATOM   4213 N  N     . LEU A 1 596 ? 101.003 118.443 107.916 1.00 13.42 ? 596 LEU A N     1 
ATOM   4214 C  CA    . LEU A 1 596 ? 102.382 118.160 108.303 1.00 13.42 ? 596 LEU A CA    1 
ATOM   4215 C  C     . LEU A 1 596 ? 103.393 118.826 107.363 1.00 13.42 ? 596 LEU A C     1 
ATOM   4216 O  O     . LEU A 1 596 ? 104.384 119.397 107.835 1.00 13.42 ? 596 LEU A O     1 
ATOM   4217 C  CB    . LEU A 1 596 ? 102.608 116.654 108.364 1.00 13.42 ? 596 LEU A CB    1 
ATOM   4218 C  CG    . LEU A 1 596 ? 103.953 116.224 108.935 1.00 13.42 ? 596 LEU A CG    1 
ATOM   4219 C  CD1   . LEU A 1 596 ? 104.230 116.941 110.241 1.00 13.42 ? 596 LEU A CD1   1 
ATOM   4220 C  CD2   . LEU A 1 596 ? 103.976 114.727 109.131 1.00 13.42 ? 596 LEU A CD2   1 
ATOM   4221 N  N     . ASP A 1 597 ? 103.166 118.773 106.045 1.00 14.55 ? 597 ASP A N     1 
ATOM   4222 C  CA    . ASP A 1 597 ? 104.022 119.502 105.109 1.00 14.55 ? 597 ASP A CA    1 
ATOM   4223 C  C     . ASP A 1 597 ? 103.997 120.996 105.380 1.00 14.55 ? 597 ASP A C     1 
ATOM   4224 O  O     . ASP A 1 597 ? 105.040 121.661 105.354 1.00 14.55 ? 597 ASP A O     1 
ATOM   4225 C  CB    . ASP A 1 597 ? 103.596 119.249 103.661 1.00 14.55 ? 597 ASP A CB    1 
ATOM   4226 C  CG    . ASP A 1 597 ? 104.058 117.916 103.132 1.00 14.55 ? 597 ASP A CG    1 
ATOM   4227 O  OD1   . ASP A 1 597 ? 105.108 117.432 103.589 1.00 14.55 ? 597 ASP A OD1   1 
ATOM   4228 O  OD2   . ASP A 1 597 ? 103.388 117.368 102.232 1.00 14.55 ? 597 ASP A OD2   1 
ATOM   4229 N  N     . ALA A 1 598 ? 102.803 121.553 105.594 1.00 11.05 ? 598 ALA A N     1 
ATOM   4230 C  CA    . ALA A 1 598 ? 102.714 122.989 105.838 1.00 11.05 ? 598 ALA A CA    1 
ATOM   4231 C  C     . ALA A 1 598 ? 103.544 123.392 107.048 1.00 11.05 ? 598 ALA A C     1 
ATOM   4232 O  O     . ALA A 1 598 ? 104.294 124.375 106.991 1.00 11.05 ? 598 ALA A O     1 
ATOM   4233 C  CB    . ALA A 1 598 ? 101.255 123.406 106.020 1.00 11.05 ? 598 ALA A CB    1 
ATOM   4234 N  N     . MET A 1 599 ? 103.454 122.625 108.134 1.00 12.51 ? 599 MET A N     1 
ATOM   4235 C  CA    . MET A 1 599 ? 104.214 122.899 109.347 1.00 12.51 ? 599 MET A CA    1 
ATOM   4236 C  C     . MET A 1 599 ? 105.718 122.725 109.153 1.00 12.51 ? 599 MET A C     1 
ATOM   4237 O  O     . MET A 1 599 ? 106.504 123.543 109.652 1.00 12.51 ? 599 MET A O     1 
ATOM   4238 C  CB    . MET A 1 599 ? 103.714 121.996 110.476 1.00 12.51 ? 599 MET A CB    1 
ATOM   4239 C  CG    . MET A 1 599 ? 102.355 122.411 111.022 1.00 12.51 ? 599 MET A CG    1 
ATOM   4240 S  SD    . MET A 1 599 ? 101.529 121.147 112.004 1.00 12.51 ? 599 MET A SD    1 
ATOM   4241 C  CE    . MET A 1 599 ? 102.907 120.407 112.855 1.00 12.51 ? 599 MET A CE    1 
ATOM   4242 N  N     . ASP A 1 600 ? 106.139 121.681 108.433 1.00 14.02 ? 600 ASP A N     1 
ATOM   4243 C  CA    . ASP A 1 600 ? 107.565 121.491 108.167 1.00 14.02 ? 600 ASP A CA    1 
ATOM   4244 C  C     . ASP A 1 600 ? 108.138 122.655 107.369 1.00 14.02 ? 600 ASP A C     1 
ATOM   4245 O  O     . ASP A 1 600 ? 109.243 123.127 107.647 1.00 14.02 ? 600 ASP A O     1 
ATOM   4246 C  CB    . ASP A 1 600 ? 107.802 120.175 107.430 1.00 14.02 ? 600 ASP A CB    1 
ATOM   4247 C  CG    . ASP A 1 600 ? 107.952 119.005 108.369 1.00 14.02 ? 600 ASP A CG    1 
ATOM   4248 O  OD1   . ASP A 1 600 ? 108.310 119.232 109.539 1.00 14.02 ? 600 ASP A OD1   1 
ATOM   4249 O  OD2   . ASP A 1 600 ? 107.733 117.855 107.937 1.00 14.02 ? 600 ASP A OD2   1 
ATOM   4250 N  N     . SER A 1 601 ? 107.403 123.121 106.360 1.00 15.45 ? 601 SER A N     1 
ATOM   4251 C  CA    . SER A 1 601 ? 107.869 124.260 105.578 1.00 15.45 ? 601 SER A CA    1 
ATOM   4252 C  C     . SER A 1 601 ? 107.895 125.539 106.408 1.00 15.45 ? 601 SER A C     1 
ATOM   4253 O  O     . SER A 1 601 ? 108.807 126.364 106.259 1.00 15.45 ? 601 SER A O     1 
ATOM   4254 C  CB    . SER A 1 601 ? 106.985 124.434 104.345 1.00 15.45 ? 601 SER A CB    1 
ATOM   4255 O  OG    . SER A 1 601 ? 107.472 125.465 103.513 1.00 15.45 ? 601 SER A OG    1 
ATOM   4256 N  N     . TYR A 1 602 ? 106.907 125.719 107.289 1.00 16.18 ? 602 TYR A N     1 
ATOM   4257 C  CA    . TYR A 1 602 ? 106.871 126.903 108.142 1.00 16.18 ? 602 TYR A CA    1 
ATOM   4258 C  C     . TYR A 1 602 ? 108.055 126.939 109.101 1.00 16.18 ? 602 TYR A C     1 
ATOM   4259 O  O     . TYR A 1 602 ? 108.591 128.017 109.397 1.00 16.18 ? 602 TYR A O     1 
ATOM   4260 C  CB    . TYR A 1 602 ? 105.552 126.934 108.907 1.00 16.18 ? 602 TYR A CB    1 
ATOM   4261 C  CG    . TYR A 1 602 ? 105.419 128.060 109.889 1.00 16.18 ? 602 TYR A CG    1 
ATOM   4262 C  CD1   . TYR A 1 602 ? 105.165 129.352 109.463 1.00 16.18 ? 602 TYR A CD1   1 
ATOM   4263 C  CD2   . TYR A 1 602 ? 105.524 127.826 111.247 1.00 16.18 ? 602 TYR A CD2   1 
ATOM   4264 C  CE1   . TYR A 1 602 ? 105.035 130.382 110.361 1.00 16.18 ? 602 TYR A CE1   1 
ATOM   4265 C  CE2   . TYR A 1 602 ? 105.391 128.846 112.152 1.00 16.18 ? 602 TYR A CE2   1 
ATOM   4266 C  CZ    . TYR A 1 602 ? 105.148 130.123 111.706 1.00 16.18 ? 602 TYR A CZ    1 
ATOM   4267 O  OH    . TYR A 1 602 ? 105.017 131.144 112.615 1.00 16.18 ? 602 TYR A OH    1 
ATOM   4268 N  N     . ASN A 1 603 ? 108.465 125.774 109.610 1.00 16.11 ? 603 ASN A N     1 
ATOM   4269 C  CA    . ASN A 1 603 ? 109.656 125.730 110.455 1.00 16.11 ? 603 ASN A CA    1 
ATOM   4270 C  C     . ASN A 1 603 ? 110.860 126.335 109.748 1.00 16.11 ? 603 ASN A C     1 
ATOM   4271 O  O     . ASN A 1 603 ? 111.545 127.200 110.304 1.00 16.11 ? 603 ASN A O     1 
ATOM   4272 C  CB    . ASN A 1 603 ? 109.985 124.299 110.859 1.00 16.11 ? 603 ASN A CB    1 
ATOM   4273 C  CG    . ASN A 1 603 ? 111.122 124.234 111.854 1.00 16.11 ? 603 ASN A CG    1 
ATOM   4274 O  OD1   . ASN A 1 603 ? 111.612 125.260 112.321 1.00 16.11 ? 603 ASN A OD1   1 
ATOM   4275 N  ND2   . ASN A 1 603 ? 111.597 123.031 112.131 1.00 16.11 ? 603 ASN A ND2   1 
ATOM   4276 N  N     . SER A 1 604 ? 111.150 125.871 108.533 1.00 17.39 ? 604 SER A N     1 
ATOM   4277 C  CA    . SER A 1 604 ? 112.285 126.376 107.779 1.00 17.39 ? 604 SER A CA    1 
ATOM   4278 C  C     . SER A 1 604 ? 112.105 127.822 107.357 1.00 17.39 ? 604 SER A C     1 
ATOM   4279 O  O     . SER A 1 604 ? 113.105 128.520 107.173 1.00 17.39 ? 604 SER A O     1 
ATOM   4280 C  CB    . SER A 1 604 ? 112.527 125.501 106.552 1.00 17.39 ? 604 SER A CB    1 
ATOM   4281 O  OG    . SER A 1 604 ? 112.945 124.205 106.937 1.00 17.39 ? 604 SER A OG    1 
ATOM   4282 N  N     . LEU A 1 605 ? 110.868 128.287 107.184 1.00 18.89 ? 605 LEU A N     1 
ATOM   4283 C  CA    . LEU A 1 605 ? 110.672 129.715 106.965 1.00 18.89 ? 605 LEU A CA    1 
ATOM   4284 C  C     . LEU A 1 605 ? 111.153 130.522 108.165 1.00 18.89 ? 605 LEU A C     1 
ATOM   4285 O  O     . LEU A 1 605 ? 111.957 131.453 108.020 1.00 18.89 ? 605 LEU A O     1 
ATOM   4286 C  CB    . LEU A 1 605 ? 109.202 130.014 106.685 1.00 18.89 ? 605 LEU A CB    1 
ATOM   4287 C  CG    . LEU A 1 605 ? 108.802 131.471 106.903 1.00 18.89 ? 605 LEU A CG    1 
ATOM   4288 C  CD1   . LEU A 1 605 ? 109.515 132.365 105.916 1.00 18.89 ? 605 LEU A CD1   1 
ATOM   4289 C  CD2   . LEU A 1 605 ? 107.301 131.650 106.793 1.00 18.89 ? 605 LEU A CD2   1 
ATOM   4290 N  N     . LEU A 1 606 ? 110.685 130.164 109.363 1.00 21.35 ? 606 LEU A N     1 
ATOM   4291 C  CA    . LEU A 1 606 ? 111.096 130.906 110.553 1.00 21.35 ? 606 LEU A CA    1 
ATOM   4292 C  C     . LEU A 1 606 ? 112.589 130.777 110.818 1.00 21.35 ? 606 LEU A C     1 
ATOM   4293 O  O     . LEU A 1 606 ? 113.230 131.754 111.214 1.00 21.35 ? 606 LEU A O     1 
ATOM   4294 C  CB    . LEU A 1 606 ? 110.319 130.442 111.781 1.00 21.35 ? 606 LEU A CB    1 
ATOM   4295 C  CG    . LEU A 1 606 ? 108.835 130.771 111.851 1.00 21.35 ? 606 LEU A CG    1 
ATOM   4296 C  CD1   . LEU A 1 606 ? 108.323 130.366 113.210 1.00 21.35 ? 606 LEU A CD1   1 
ATOM   4297 C  CD2   . LEU A 1 606 ? 108.597 132.242 111.597 1.00 21.35 ? 606 LEU A CD2   1 
ATOM   4298 N  N     . GLU A 1 607 ? 113.153 129.586 110.615 1.00 21.73 ? 607 GLU A N     1 
ATOM   4299 C  CA    . GLU A 1 607 ? 114.572 129.376 110.879 1.00 21.73 ? 607 GLU A CA    1 
ATOM   4300 C  C     . GLU A 1 607 ? 115.442 130.286 110.024 1.00 21.73 ? 607 GLU A C     1 
ATOM   4301 O  O     . GLU A 1 607 ? 116.382 130.904 110.531 1.00 21.73 ? 607 GLU A O     1 
ATOM   4302 C  CB    . GLU A 1 607 ? 114.924 127.911 110.631 1.00 21.73 ? 607 GLU A CB    1 
ATOM   4303 C  CG    . GLU A 1 607 ? 116.150 127.417 111.355 1.00 21.73 ? 607 GLU A CG    1 
ATOM   4304 C  CD    . GLU A 1 607 ? 116.305 125.914 111.250 1.00 21.73 ? 607 GLU A CD    1 
ATOM   4305 O  OE1   . GLU A 1 607 ? 116.765 125.437 110.192 1.00 21.73 ? 607 GLU A OE1   1 
ATOM   4306 O  OE2   . GLU A 1 607 ? 115.963 125.208 112.221 1.00 21.73 ? 607 GLU A OE2   1 
ATOM   4307 N  N     . SER A 1 608 ? 115.140 130.391 108.734 1.00 23.91 ? 608 SER A N     1 
ATOM   4308 C  CA    . SER A 1 608 ? 115.852 131.312 107.862 1.00 23.91 ? 608 SER A CA    1 
ATOM   4309 C  C     . SER A 1 608 ? 115.517 132.767 108.151 1.00 23.91 ? 608 SER A C     1 
ATOM   4310 O  O     . SER A 1 608 ? 116.313 133.647 107.807 1.00 23.91 ? 608 SER A O     1 
ATOM   4311 C  CB    . SER A 1 608 ? 115.535 130.996 106.399 1.00 23.91 ? 608 SER A CB    1 
ATOM   4312 O  OG    . SER A 1 608 ? 115.970 129.691 106.058 1.00 23.91 ? 608 SER A OG    1 
ATOM   4313 N  N     . TYR A 1 609 ? 114.358 133.042 108.758 1.00 28.05 ? 609 TYR A N     1 
ATOM   4314 C  CA    . TYR A 1 609 ? 114.008 134.423 109.084 1.00 28.05 ? 609 TYR A CA    1 
ATOM   4315 C  C     . TYR A 1 609 ? 114.990 135.054 110.063 1.00 28.05 ? 609 TYR A C     1 
ATOM   4316 O  O     . TYR A 1 609 ? 115.392 136.207 109.879 1.00 28.05 ? 609 TYR A O     1 
ATOM   4317 C  CB    . TYR A 1 609 ? 112.596 134.486 109.656 1.00 28.05 ? 609 TYR A CB    1 
ATOM   4318 C  CG    . TYR A 1 609 ? 112.224 135.827 110.235 1.00 28.05 ? 609 TYR A CG    1 
ATOM   4319 C  CD1   . TYR A 1 609 ? 112.292 136.057 111.600 1.00 28.05 ? 609 TYR A CD1   1 
ATOM   4320 C  CD2   . TYR A 1 609 ? 111.813 136.862 109.418 1.00 28.05 ? 609 TYR A CD2   1 
ATOM   4321 C  CE1   . TYR A 1 609 ? 111.953 137.281 112.131 1.00 28.05 ? 609 TYR A CE1   1 
ATOM   4322 C  CE2   . TYR A 1 609 ? 111.470 138.089 109.940 1.00 28.05 ? 609 TYR A CE2   1 
ATOM   4323 C  CZ    . TYR A 1 609 ? 111.543 138.294 111.295 1.00 28.05 ? 609 TYR A CZ    1 
ATOM   4324 O  OH    . TYR A 1 609 ? 111.203 139.522 111.810 1.00 28.05 ? 609 TYR A OH    1 
ATOM   4325 N  N     . GLN A 1 610 ? 115.389 134.322 111.101 1.00 27.63 ? 610 GLN A N     1 
ATOM   4326 C  CA    . GLN A 1 610 ? 116.216 134.862 112.170 1.00 27.63 ? 610 GLN A CA    1 
ATOM   4327 C  C     . GLN A 1 610 ? 117.703 134.794 111.850 1.00 27.63 ? 610 GLN A C     1 
ATOM   4328 O  O     . GLN A 1 610 ? 118.530 134.819 112.766 1.00 27.63 ? 610 GLN A O     1 
ATOM   4329 C  CB    . GLN A 1 610 ? 115.907 134.130 113.475 1.00 27.63 ? 610 GLN A CB    1 
ATOM   4330 C  CG    . GLN A 1 610 ? 116.227 132.649 113.448 1.00 27.63 ? 610 GLN A CG    1 
ATOM   4331 C  CD    . GLN A 1 610 ? 115.514 131.885 114.545 1.00 27.63 ? 610 GLN A CD    1 
ATOM   4332 O  OE1   . GLN A 1 610 ? 114.691 132.442 115.272 1.00 27.63 ? 610 GLN A OE1   1 
ATOM   4333 N  NE2   . GLN A 1 610 ? 115.826 130.602 114.670 1.00 27.63 ? 610 GLN A NE2   1 
ATOM   4334 N  N     . ARG A 1 611 ? 118.056 134.713 110.568 1.00 29.72 ? 611 ARG A N     1 
ATOM   4335 C  CA    . ARG A 1 611 ? 119.442 134.687 110.130 1.00 29.72 ? 611 ARG A CA    1 
ATOM   4336 C  C     . ARG A 1 611 ? 119.787 135.841 109.204 1.00 29.72 ? 611 ARG A C     1 
ATOM   4337 O  O     . ARG A 1 611 ? 120.908 135.879 108.686 1.00 29.72 ? 611 ARG A O     1 
ATOM   4338 C  CB    . ARG A 1 611 ? 119.752 133.373 109.405 1.00 29.72 ? 611 ARG A CB    1 
ATOM   4339 C  CG    . ARG A 1 611 ? 119.476 132.117 110.194 1.00 29.72 ? 611 ARG A CG    1 
ATOM   4340 C  CD    . ARG A 1 611 ? 120.576 131.809 111.166 1.00 29.72 ? 611 ARG A CD    1 
ATOM   4341 N  NE    . ARG A 1 611 ? 120.312 130.569 111.881 1.00 29.72 ? 611 ARG A NE    1 
ATOM   4342 C  CZ    . ARG A 1 611 ? 120.555 129.361 111.391 1.00 29.72 ? 611 ARG A CZ    1 
ATOM   4343 N  NH1   . ARG A 1 611 ? 121.039 129.196 110.172 1.00 29.72 ? 611 ARG A NH1   1 
ATOM   4344 N  NH2   . ARG A 1 611 ? 120.301 128.293 112.141 1.00 29.72 ? 611 ARG A NH2   1 
ATOM   4345 N  N     . MET A 1 612 ? 118.862 136.776 108.974 1.00 34.86 ? 612 MET A N     1 
ATOM   4346 C  CA    . MET A 1 612 ? 119.086 137.808 107.966 1.00 34.86 ? 612 MET A CA    1 
ATOM   4347 C  C     . MET A 1 612 ? 120.310 138.652 108.297 1.00 34.86 ? 612 MET A C     1 
ATOM   4348 O  O     . MET A 1 612 ? 121.074 139.036 107.404 1.00 34.86 ? 612 MET A O     1 
ATOM   4349 C  CB    . MET A 1 612 ? 117.840 138.682 107.815 1.00 34.86 ? 612 MET A CB    1 
ATOM   4350 C  CG    . MET A 1 612 ? 116.640 137.941 107.240 1.00 34.86 ? 612 MET A CG    1 
ATOM   4351 S  SD    . MET A 1 612 ? 115.194 138.987 106.997 1.00 34.86 ? 612 MET A SD    1 
ATOM   4352 C  CE    . MET A 1 612 ? 114.638 139.207 108.676 1.00 34.86 ? 612 MET A CE    1 
ATOM   4353 N  N     . HIS A 1 613 ? 120.511 138.962 109.576 1.00 40.75 ? 613 HIS A N     1 
ATOM   4354 C  CA    . HIS A 1 613 ? 121.749 139.618 109.974 1.00 40.75 ? 613 HIS A CA    1 
ATOM   4355 C  C     . HIS A 1 613 ? 122.911 138.631 110.033 1.00 40.75 ? 613 HIS A C     1 
ATOM   4356 O  O     . HIS A 1 613 ? 124.038 138.974 109.661 1.00 40.75 ? 613 HIS A O     1 
ATOM   4357 C  CB    . HIS A 1 613 ? 121.570 140.307 111.327 1.00 40.75 ? 613 HIS A CB    1 
ATOM   4358 C  CG    . HIS A 1 613 ? 121.454 139.356 112.477 1.00 40.75 ? 613 HIS A CG    1 
ATOM   4359 N  ND1   . HIS A 1 613 ? 120.243 138.892 112.941 1.00 40.75 ? 613 HIS A ND1   1 
ATOM   4360 C  CD2   . HIS A 1 613 ? 122.401 138.776 113.252 1.00 40.75 ? 613 HIS A CD2   1 
ATOM   4361 C  CE1   . HIS A 1 613 ? 120.448 138.070 113.954 1.00 40.75 ? 613 HIS A CE1   1 
ATOM   4362 N  NE2   . HIS A 1 613 ? 121.748 137.980 114.162 1.00 40.75 ? 613 HIS A NE2   1 
ATOM   4363 N  N     . LEU A 1 614 ? 122.652 137.402 110.481 1.00 37.91 ? 614 LEU A N     1 
ATOM   4364 C  CA    . LEU A 1 614 ? 123.709 136.435 110.792 1.00 37.91 ? 614 LEU A CA    1 
ATOM   4365 C  C     . LEU A 1 614 ? 124.117 135.705 109.512 1.00 37.91 ? 614 LEU A C     1 
ATOM   4366 O  O     . LEU A 1 614 ? 124.048 134.483 109.388 1.00 37.91 ? 614 LEU A O     1 
ATOM   4367 C  CB    . LEU A 1 614 ? 123.233 135.477 111.879 1.00 37.91 ? 614 LEU A CB    1 
ATOM   4368 C  CG    . LEU A 1 614 ? 124.182 134.602 112.704 1.00 37.91 ? 614 LEU A CG    1 
ATOM   4369 C  CD1   . LEU A 1 614 ? 123.603 134.445 114.103 1.00 37.91 ? 614 LEU A CD1   1 
ATOM   4370 C  CD2   . LEU A 1 614 ? 124.405 133.228 112.091 1.00 37.91 ? 614 LEU A CD2   1 
ATOM   4371 N  N     . SER A 1 615 ? 124.554 136.498 108.541 1.00 43.63 ? 615 SER A N     1 
ATOM   4372 C  CA    . SER A 1 615 ? 124.926 135.972 107.235 1.00 43.63 ? 615 SER A CA    1 
ATOM   4373 C  C     . SER A 1 615 ? 126.326 135.364 107.263 1.00 43.63 ? 615 SER A C     1 
ATOM   4374 O  O     . SER A 1 615 ? 126.512 134.228 107.702 1.00 43.63 ? 615 SER A O     1 
ATOM   4375 C  CB    . SER A 1 615 ? 124.848 137.074 106.179 1.00 43.63 ? 615 SER A CB    1 
ATOM   4376 O  OG    . SER A 1 615 ? 125.562 138.226 106.593 1.00 43.63 ? 615 SER A OG    1 
ATOM   4377 N  N     . ASP A 1 627 ? 111.571 121.607 118.039 1.00 30.51 ? 627 ASP A N     1 
ATOM   4378 C  CA    . ASP A 1 627 ? 110.576 121.266 119.047 1.00 30.51 ? 627 ASP A CA    1 
ATOM   4379 C  C     . ASP A 1 627 ? 110.142 119.811 118.925 1.00 30.51 ? 627 ASP A C     1 
ATOM   4380 O  O     . ASP A 1 627 ? 110.338 119.180 117.888 1.00 30.51 ? 627 ASP A O     1 
ATOM   4381 C  CB    . ASP A 1 627 ? 109.358 122.189 118.937 1.00 30.51 ? 627 ASP A CB    1 
ATOM   4382 C  CG    . ASP A 1 627 ? 108.725 122.161 117.558 1.00 30.51 ? 627 ASP A CG    1 
ATOM   4383 O  OD1   . ASP A 1 627 ? 109.318 121.560 116.639 1.00 30.51 ? 627 ASP A OD1   1 
ATOM   4384 O  OD2   . ASP A 1 627 ? 107.629 122.737 117.396 1.00 30.51 ? 627 ASP A OD2   1 
ATOM   4385 N  N     . THR A 1 628 ? 109.548 119.286 119.996 1.00 23.95 ? 628 THR A N     1 
ATOM   4386 C  CA    . THR A 1 628 ? 109.074 117.908 120.031 1.00 23.95 ? 628 THR A CA    1 
ATOM   4387 C  C     . THR A 1 628 ? 107.564 117.814 119.840 1.00 23.95 ? 628 THR A C     1 
ATOM   4388 O  O     . THR A 1 628 ? 107.009 116.713 119.863 1.00 23.95 ? 628 THR A O     1 
ATOM   4389 C  CB    . THR A 1 628 ? 109.487 117.238 121.340 1.00 23.95 ? 628 THR A CB    1 
ATOM   4390 O  OG1   . THR A 1 628 ? 109.040 118.031 122.446 1.00 23.95 ? 628 THR A OG1   1 
ATOM   4391 C  CG2   . THR A 1 628 ? 110.993 117.098 121.407 1.00 23.95 ? 628 THR A CG2   1 
ATOM   4392 N  N     . LYS A 1 629 ? 106.886 118.946 119.653 1.00 24.11 ? 629 LYS A N     1 
ATOM   4393 C  CA    . LYS A 1 629 ? 105.468 118.946 119.331 1.00 24.11 ? 629 LYS A CA    1 
ATOM   4394 C  C     . LYS A 1 629 ? 105.194 118.845 117.841 1.00 24.11 ? 629 LYS A C     1 
ATOM   4395 O  O     . LYS A 1 629 ? 104.033 118.699 117.452 1.00 24.11 ? 629 LYS A O     1 
ATOM   4396 C  CB    . LYS A 1 629 ? 104.792 120.211 119.874 1.00 24.11 ? 629 LYS A CB    1 
ATOM   4397 C  CG    . LYS A 1 629 ? 104.720 120.270 121.380 1.00 24.11 ? 629 LYS A CG    1 
ATOM   4398 C  CD    . LYS A 1 629 ? 103.999 121.514 121.837 1.00 24.11 ? 629 LYS A CD    1 
ATOM   4399 C  CE    . LYS A 1 629 ? 103.991 121.613 123.347 1.00 24.11 ? 629 LYS A CE    1 
ATOM   4400 N  NZ    . LYS A 1 629 ? 103.162 120.548 123.964 1.00 24.11 ? 629 LYS A NZ    1 
ATOM   4401 N  N     . ARG A 1 630 ? 106.225 118.941 117.007 1.00 16.88 ? 630 ARG A N     1 
ATOM   4402 C  CA    . ARG A 1 630 ? 106.099 118.719 115.575 1.00 16.88 ? 630 ARG A CA    1 
ATOM   4403 C  C     . ARG A 1 630 ? 106.635 117.359 115.165 1.00 16.88 ? 630 ARG A C     1 
ATOM   4404 O  O     . ARG A 1 630 ? 106.261 116.844 114.108 1.00 16.88 ? 630 ARG A O     1 
ATOM   4405 C  CB    . ARG A 1 630 ? 106.835 119.820 114.812 1.00 16.88 ? 630 ARG A CB    1 
ATOM   4406 C  CG    . ARG A 1 630 ? 106.451 119.964 113.355 1.00 16.88 ? 630 ARG A CG    1 
ATOM   4407 C  CD    . ARG A 1 630 ? 107.245 121.088 112.738 1.00 16.88 ? 630 ARG A CD    1 
ATOM   4408 N  NE    . ARG A 1 630 ? 108.323 120.587 111.900 1.00 16.88 ? 630 ARG A NE    1 
ATOM   4409 C  CZ    . ARG A 1 630 ? 109.607 120.678 112.211 1.00 16.88 ? 630 ARG A CZ    1 
ATOM   4410 N  NH1   . ARG A 1 630 ? 110.000 121.158 113.378 1.00 16.88 ? 630 ARG A NH1   1 
ATOM   4411 N  NH2   . ARG A 1 630 ? 110.518 120.259 111.340 1.00 16.88 ? 630 ARG A NH2   1 
ATOM   4412 N  N     . ALA A 1 631 ? 107.505 116.773 115.979 1.00 12.69 ? 631 ALA A N     1 
ATOM   4413 C  CA    . ALA A 1 631 ? 107.982 115.416 115.782 1.00 12.69 ? 631 ALA A CA    1 
ATOM   4414 C  C     . ALA A 1 631 ? 107.096 114.382 116.459 1.00 12.69 ? 631 ALA A C     1 
ATOM   4415 O  O     . ALA A 1 631 ? 107.367 113.184 116.341 1.00 12.69 ? 631 ALA A O     1 
ATOM   4416 C  CB    . ALA A 1 631 ? 109.415 115.282 116.299 1.00 12.69 ? 631 ALA A CB    1 
ATOM   4417 N  N     . SER A 1 632 ? 106.062 114.818 117.178 1.00 19.09 ? 632 SER A N     1 
ATOM   4418 C  CA    . SER A 1 632 ? 105.055 113.926 117.738 1.00 19.09 ? 632 SER A CA    1 
ATOM   4419 C  C     . SER A 1 632 ? 103.812 113.824 116.870 1.00 19.09 ? 632 SER A C     1 
ATOM   4420 O  O     . SER A 1 632 ? 103.201 112.752 116.798 1.00 19.09 ? 632 SER A O     1 
ATOM   4421 C  CB    . SER A 1 632 ? 104.656 114.394 119.139 1.00 19.09 ? 632 SER A CB    1 
ATOM   4422 O  OG    . SER A 1 632 ? 105.678 114.109 120.076 1.00 19.09 ? 632 SER A OG    1 
ATOM   4423 N  N     . PHE A 1 633 ? 103.437 114.911 116.194 1.00 17.02 ? 633 PHE A N     1 
ATOM   4424 C  CA    . PHE A 1 633 ? 102.378 114.841 115.197 1.00 17.02 ? 633 PHE A CA    1 
ATOM   4425 C  C     . PHE A 1 633 ? 102.757 113.904 114.059 1.00 17.02 ? 633 PHE A C     1 
ATOM   4426 O  O     . PHE A 1 633 ? 101.907 113.160 113.561 1.00 17.02 ? 633 PHE A O     1 
ATOM   4427 C  CB    . PHE A 1 633 ? 102.074 116.241 114.667 1.00 17.02 ? 633 PHE A CB    1 
ATOM   4428 C  CG    . PHE A 1 633 ? 100.787 116.339 113.904 1.00 17.02 ? 633 PHE A CG    1 
ATOM   4429 C  CD1   . PHE A 1 633 ? 99.630  115.768 114.393 1.00 17.02 ? 633 PHE A CD1   1 
ATOM   4430 C  CD2   . PHE A 1 633 ? 100.728 117.030 112.708 1.00 17.02 ? 633 PHE A CD2   1 
ATOM   4431 C  CE1   . PHE A 1 633 ? 98.447  115.867 113.692 1.00 17.02 ? 633 PHE A CE1   1 
ATOM   4432 C  CE2   . PHE A 1 633 ? 99.544  117.133 112.006 1.00 17.02 ? 633 PHE A CE2   1 
ATOM   4433 C  CZ    . PHE A 1 633 ? 98.406  116.551 112.499 1.00 17.02 ? 633 PHE A CZ    1 
ATOM   4434 N  N     . ARG A 1 634 ? 104.025 113.917 113.646 1.00 25.90 ? 634 ARG A N     1 
ATOM   4435 C  CA    . ARG A 1 634 ? 104.495 113.004 112.610 1.00 25.90 ? 634 ARG A CA    1 
ATOM   4436 C  C     . ARG A 1 634 ? 104.425 111.549 113.066 1.00 25.90 ? 634 ARG A C     1 
ATOM   4437 O  O     . ARG A 1 634 ? 104.025 110.673 112.289 1.00 25.90 ? 634 ARG A O     1 
ATOM   4438 C  CB    . ARG A 1 634 ? 105.919 113.391 112.210 1.00 25.90 ? 634 ARG A CB    1 
ATOM   4439 C  CG    . ARG A 1 634 ? 106.411 112.815 110.895 1.00 25.90 ? 634 ARG A CG    1 
ATOM   4440 C  CD    . ARG A 1 634 ? 107.910 113.036 110.712 1.00 25.90 ? 634 ARG A CD    1 
ATOM   4441 N  NE    . ARG A 1 634 ? 108.307 114.407 111.011 1.00 25.90 ? 634 ARG A NE    1 
ATOM   4442 C  CZ    . ARG A 1 634 ? 108.294 115.404 110.137 1.00 25.90 ? 634 ARG A CZ    1 
ATOM   4443 N  NH1   . ARG A 1 634 ? 107.941 115.216 108.877 1.00 25.90 ? 634 ARG A NH1   1 
ATOM   4444 N  NH2   . ARG A 1 634 ? 108.640 116.622 110.537 1.00 25.90 ? 634 ARG A NH2   1 
ATOM   4445 N  N     . ASP A 1 635 ? 104.797 111.276 114.319 1.00 30.77 ? 635 ASP A N     1 
ATOM   4446 C  CA    . ASP A 1 635 ? 104.672 109.931 114.872 1.00 30.77 ? 635 ASP A CA    1 
ATOM   4447 C  C     . ASP A 1 635 ? 103.220 109.468 114.912 1.00 30.77 ? 635 ASP A C     1 
ATOM   4448 O  O     . ASP A 1 635 ? 102.913 108.328 114.531 1.00 30.77 ? 635 ASP A O     1 
ATOM   4449 C  CB    . ASP A 1 635 ? 105.268 109.906 116.278 1.00 30.77 ? 635 ASP A CB    1 
ATOM   4450 C  CG    . ASP A 1 635 ? 105.778 108.543 116.674 1.00 30.77 ? 635 ASP A CG    1 
ATOM   4451 O  OD1   . ASP A 1 635 ? 105.988 108.308 117.881 1.00 30.77 ? 635 ASP A OD1   1 
ATOM   4452 O  OD2   . ASP A 1 635 ? 105.992 107.712 115.777 1.00 30.77 ? 635 ASP A OD2   1 
ATOM   4453 N  N     . LEU A 1 636 ? 102.316 110.342 115.358 1.00 26.12 ? 636 LEU A N     1 
ATOM   4454 C  CA    . LEU A 1 636 ? 100.899 110.001 115.375 1.00 26.12 ? 636 LEU A CA    1 
ATOM   4455 C  C     . LEU A 1 636 ? 100.380 109.726 113.971 1.00 26.12 ? 636 LEU A C     1 
ATOM   4456 O  O     . LEU A 1 636 ? 99.602  108.790 113.768 1.00 26.12 ? 636 LEU A O     1 
ATOM   4457 C  CB    . LEU A 1 636 ? 100.099 111.123 116.034 1.00 26.12 ? 636 LEU A CB    1 
ATOM   4458 C  CG    . LEU A 1 636 ? 98.585  111.109 115.835 1.00 26.12 ? 636 LEU A CG    1 
ATOM   4459 C  CD1   . LEU A 1 636 ? 97.970  109.906 116.517 1.00 26.12 ? 636 LEU A CD1   1 
ATOM   4460 C  CD2   . LEU A 1 636 ? 97.969  112.391 116.353 1.00 26.12 ? 636 LEU A CD2   1 
ATOM   4461 N  N     . LEU A 1 637 ? 100.792 110.533 112.991 1.00 35.85 ? 637 LEU A N     1 
ATOM   4462 C  CA    . LEU A 1 637 ? 100.333 110.329 111.621 1.00 35.85 ? 637 LEU A CA    1 
ATOM   4463 C  C     . LEU A 1 637 ? 100.832 109.012 111.045 1.00 35.85 ? 637 LEU A C     1 
ATOM   4464 O  O     . LEU A 1 637 ? 100.077 108.313 110.357 1.00 35.85 ? 637 LEU A O     1 
ATOM   4465 C  CB    . LEU A 1 637 ? 100.773 111.493 110.742 1.00 35.85 ? 637 LEU A CB    1 
ATOM   4466 C  CG    . LEU A 1 637 ? 100.008 112.784 111.006 1.00 35.85 ? 637 LEU A CG    1 
ATOM   4467 C  CD1   . LEU A 1 637 ? 100.322 113.815 109.950 1.00 35.85 ? 637 LEU A CD1   1 
ATOM   4468 C  CD2   . LEU A 1 637 ? 98.521  112.508 111.065 1.00 35.85 ? 637 LEU A CD2   1 
ATOM   4469 N  N     . ARG A 1 638 ? 102.088 108.655 111.305 1.00 22.78 ? 638 ARG A N     1 
ATOM   4470 C  CA    . ARG A 1 638 ? 102.564 107.349 110.865 1.00 22.78 ? 638 ARG A CA    1 
ATOM   4471 C  C     . ARG A 1 638 ? 101.767 106.217 111.498 1.00 22.78 ? 638 ARG A C     1 
ATOM   4472 O  O     . ARG A 1 638 ? 101.407 105.253 110.809 1.00 22.78 ? 638 ARG A O     1 
ATOM   4473 C  CB    . ARG A 1 638 ? 104.042 107.183 111.193 1.00 22.78 ? 638 ARG A CB    1 
ATOM   4474 C  CG    . ARG A 1 638 ? 104.968 108.112 110.464 1.00 22.78 ? 638 ARG A CG    1 
ATOM   4475 C  CD    . ARG A 1 638 ? 106.402 107.807 110.829 1.00 22.78 ? 638 ARG A CD    1 
ATOM   4476 N  NE    . ARG A 1 638 ? 107.138 109.021 111.149 1.00 22.78 ? 638 ARG A NE    1 
ATOM   4477 C  CZ    . ARG A 1 638 ? 108.096 109.098 112.059 1.00 22.78 ? 638 ARG A CZ    1 
ATOM   4478 N  NH1   . ARG A 1 638 ? 108.471 108.041 112.756 1.00 22.78 ? 638 ARG A NH1   1 
ATOM   4479 N  NH2   . ARG A 1 638 ? 108.693 110.265 112.274 1.00 22.78 ? 638 ARG A NH2   1 
ATOM   4480 N  N     . ARG A 1 639 ? 101.485 106.309 112.801 1.00 23.06 ? 639 ARG A N     1 
ATOM   4481 C  CA    . ARG A 1 639 ? 100.710 105.254 113.450 1.00 23.06 ? 639 ARG A CA    1 
ATOM   4482 C  C     . ARG A 1 639 ? 99.294  105.165 112.892 1.00 23.06 ? 639 ARG A C     1 
ATOM   4483 O  O     . ARG A 1 639 ? 98.761  104.062 112.723 1.00 23.06 ? 639 ARG A O     1 
ATOM   4484 C  CB    . ARG A 1 639 ? 100.679 105.478 114.959 1.00 23.06 ? 639 ARG A CB    1 
ATOM   4485 C  CG    . ARG A 1 639 ? 102.027 105.328 115.630 1.00 23.06 ? 639 ARG A CG    1 
ATOM   4486 C  CD    . ARG A 1 639 ? 102.299 103.890 116.001 1.00 23.06 ? 639 ARG A CD    1 
ATOM   4487 N  NE    . ARG A 1 639 ? 103.431 103.763 116.908 1.00 23.06 ? 639 ARG A NE    1 
ATOM   4488 C  CZ    . ARG A 1 639 ? 104.199 102.688 117.000 1.00 23.06 ? 639 ARG A CZ    1 
ATOM   4489 N  NH1   . ARG A 1 639 ? 103.984 101.621 116.251 1.00 23.06 ? 639 ARG A NH1   1 
ATOM   4490 N  NH2   . ARG A 1 639 ? 105.205 102.682 117.866 1.00 23.06 ? 639 ARG A NH2   1 
ATOM   4491 N  N     . ARG A 1 640 ? 98.671  106.307 112.599 1.00 23.15 ? 640 ARG A N     1 
ATOM   4492 C  CA    . ARG A 1 640 ? 97.337  106.292 112.011 1.00 23.15 ? 640 ARG A CA    1 
ATOM   4493 C  C     . ARG A 1 640 ? 97.345  105.656 110.627 1.00 23.15 ? 640 ARG A C     1 
ATOM   4494 O  O     . ARG A 1 640 ? 96.421  104.913 110.277 1.00 23.15 ? 640 ARG A O     1 
ATOM   4495 C  CB    . ARG A 1 640 ? 96.772  107.710 111.939 1.00 23.15 ? 640 ARG A CB    1 
ATOM   4496 C  CG    . ARG A 1 640 ? 96.560  108.374 113.285 1.00 23.15 ? 640 ARG A CG    1 
ATOM   4497 C  CD    . ARG A 1 640 ? 95.218  108.026 113.883 1.00 23.15 ? 640 ARG A CD    1 
ATOM   4498 N  NE    . ARG A 1 640 ? 94.129  108.230 112.939 1.00 23.15 ? 640 ARG A NE    1 
ATOM   4499 C  CZ    . ARG A 1 640 ? 93.558  109.400 112.698 1.00 23.15 ? 640 ARG A CZ    1 
ATOM   4500 N  NH1   . ARG A 1 640 ? 93.957  110.501 113.311 1.00 23.15 ? 640 ARG A NH1   1 
ATOM   4501 N  NH2   . ARG A 1 640 ? 92.561  109.467 111.823 1.00 23.15 ? 640 ARG A NH2   1 
ATOM   4502 N  N     . VAL A 1 641 ? 98.368  105.946 109.817 1.00 19.42 ? 641 VAL A N     1 
ATOM   4503 C  CA    . VAL A 1 641 ? 98.467  105.326 108.495 1.00 19.42 ? 641 VAL A CA    1 
ATOM   4504 C  C     . VAL A 1 641 ? 98.611  103.814 108.625 1.00 19.42 ? 641 VAL A C     1 
ATOM   4505 O  O     . VAL A 1 641 ? 97.933  103.040 107.931 1.00 19.42 ? 641 VAL A O     1 
ATOM   4506 C  CB    . VAL A 1 641 ? 99.640  105.937 107.705 1.00 19.42 ? 641 VAL A CB    1 
ATOM   4507 C  CG1   . VAL A 1 641 ? 100.008 105.060 106.527 1.00 19.42 ? 641 VAL A CG1   1 
ATOM   4508 C  CG2   . VAL A 1 641 ? 99.308  107.343 107.239 1.00 19.42 ? 641 VAL A CG2   1 
ATOM   4509 N  N     . ALA A 1 642 ? 99.496  103.370 109.519 1.00 18.48 ? 642 ALA A N     1 
ATOM   4510 C  CA    . ALA A 1 642 ? 99.691  101.941 109.722 1.00 18.48 ? 642 ALA A CA    1 
ATOM   4511 C  C     . ALA A 1 642 ? 98.436  101.246 110.232 1.00 18.48 ? 642 ALA A C     1 
ATOM   4512 O  O     . ALA A 1 642 ? 98.221  100.075 109.908 1.00 18.48 ? 642 ALA A O     1 
ATOM   4513 C  CB    . ALA A 1 642 ? 100.847 101.704 110.691 1.00 18.48 ? 642 ALA A CB    1 
ATOM   4514 N  N     . HIS A 1 643 ? 97.611  101.927 111.031 1.00 18.50 ? 643 HIS A N     1 
ATOM   4515 C  CA    . HIS A 1 643 ? 96.359  101.324 111.481 1.00 18.50 ? 643 HIS A CA    1 
ATOM   4516 C  C     . HIS A 1 643 ? 95.316  101.287 110.370 1.00 18.50 ? 643 HIS A C     1 
ATOM   4517 O  O     . HIS A 1 643 ? 94.565  100.310 110.249 1.00 18.50 ? 643 HIS A O     1 
ATOM   4518 C  CB    . HIS A 1 643 ? 95.811  102.081 112.689 1.00 18.50 ? 643 HIS A CB    1 
ATOM   4519 C  CG    . HIS A 1 643 ? 94.595  101.454 113.295 1.00 18.50 ? 643 HIS A CG    1 
ATOM   4520 N  ND1   . HIS A 1 643 ? 94.638  100.264 113.989 1.00 18.50 ? 643 HIS A ND1   1 
ATOM   4521 C  CD2   . HIS A 1 643 ? 93.300  101.849 113.306 1.00 18.50 ? 643 HIS A CD2   1 
ATOM   4522 C  CE1   . HIS A 1 643 ? 93.424  99.956  114.406 1.00 18.50 ? 643 HIS A CE1   1 
ATOM   4523 N  NE2   . HIS A 1 643 ? 92.593  100.900 114.003 1.00 18.50 ? 643 HIS A NE2   1 
ATOM   4524 N  N     . THR A 1 644 ? 95.242  102.352 109.567 1.00 16.64 ? 644 THR A N     1 
ATOM   4525 C  CA    . THR A 1 644 ? 94.310  102.380 108.445 1.00 16.64 ? 644 THR A CA    1 
ATOM   4526 C  C     . THR A 1 644 ? 94.597  101.256 107.464 1.00 16.64 ? 644 THR A C     1 
ATOM   4527 O  O     . THR A 1 644 ? 93.666  100.672 106.898 1.00 16.64 ? 644 THR A O     1 
ATOM   4528 C  CB    . THR A 1 644 ? 94.385  103.734 107.740 1.00 16.64 ? 644 THR A CB    1 
ATOM   4529 O  OG1   . THR A 1 644 ? 93.955  104.763 108.638 1.00 16.64 ? 644 THR A OG1   1 
ATOM   4530 C  CG2   . THR A 1 644 ? 93.506  103.756 106.511 1.00 16.64 ? 644 THR A CG2   1 
ATOM   4531 N  N     . ILE A 1 645 ? 95.872  100.936 107.249 1.00 15.49 ? 645 ILE A N     1 
ATOM   4532 C  CA    . ILE A 1 645 ? 96.203  99.811  106.377 1.00 15.49 ? 645 ILE A CA    1 
ATOM   4533 C  C     . ILE A 1 645 ? 95.759  98.489  106.997 1.00 15.49 ? 645 ILE A C     1 
ATOM   4534 O  O     . ILE A 1 645 ? 95.119  97.666  106.334 1.00 15.49 ? 645 ILE A O     1 
ATOM   4535 C  CB    . ILE A 1 645 ? 97.704  99.806  106.041 1.00 15.49 ? 645 ILE A CB    1 
ATOM   4536 C  CG1   . ILE A 1 645 ? 98.051  101.006 105.165 1.00 15.49 ? 645 ILE A CG1   1 
ATOM   4537 C  CG2   . ILE A 1 645 ? 98.099  98.514  105.365 1.00 15.49 ? 645 ILE A CG2   1 
ATOM   4538 C  CD1   . ILE A 1 645 ? 99.521  101.206 104.985 1.00 15.49 ? 645 ILE A CD1   1 
ATOM   4539 N  N     . VAL A 1 646 ? 96.075  98.267  108.276 1.00 17.42 ? 646 VAL A N     1 
ATOM   4540 C  CA    . VAL A 1 646 ? 95.860  96.944  108.864 1.00 17.42 ? 646 VAL A CA    1 
ATOM   4541 C  C     . VAL A 1 646 ? 94.381  96.672  109.087 1.00 17.42 ? 646 VAL A C     1 
ATOM   4542 O  O     . VAL A 1 646 ? 93.961  95.511  109.155 1.00 17.42 ? 646 VAL A O     1 
ATOM   4543 C  CB    . VAL A 1 646 ? 96.649  96.789  110.177 1.00 17.42 ? 646 VAL A CB    1 
ATOM   4544 C  CG1   . VAL A 1 646 ? 96.119  97.724  111.230 1.00 17.42 ? 646 VAL A CG1   1 
ATOM   4545 C  CG2   . VAL A 1 646 ? 96.597  95.358  110.670 1.00 17.42 ? 646 VAL A CG2   1 
ATOM   4546 N  N     . GLU A 1 647 ? 93.564  97.716  109.214 1.00 21.78 ? 647 GLU A N     1 
ATOM   4547 C  CA    . GLU A 1 647 ? 92.139  97.485  109.423 1.00 21.78 ? 647 GLU A CA    1 
ATOM   4548 C  C     . GLU A 1 647 ? 91.485  96.880  108.183 1.00 21.78 ? 647 GLU A C     1 
ATOM   4549 O  O     . GLU A 1 647 ? 90.592  96.034  108.297 1.00 21.78 ? 647 GLU A O     1 
ATOM   4550 C  CB    . GLU A 1 647 ? 91.458  98.789  109.828 1.00 21.78 ? 647 GLU A CB    1 
ATOM   4551 C  CG    . GLU A 1 647 ? 89.987  98.653  110.152 1.00 21.78 ? 647 GLU A CG    1 
ATOM   4552 C  CD    . GLU A 1 647 ? 89.373  99.964  110.597 1.00 21.78 ? 647 GLU A CD    1 
ATOM   4553 O  OE1   . GLU A 1 647 ? 90.098  100.980 110.629 1.00 21.78 ? 647 GLU A OE1   1 
ATOM   4554 O  OE2   . GLU A 1 647 ? 88.166  99.978  110.917 1.00 21.78 ? 647 GLU A OE2   1 
ATOM   4555 N  N     . TYR A 1 648 ? 91.920  97.297  106.990 1.00 24.75 ? 648 TYR A N     1 
ATOM   4556 C  CA    . TYR A 1 648 ? 91.327  96.791  105.754 1.00 24.75 ? 648 TYR A CA    1 
ATOM   4557 C  C     . TYR A 1 648 ? 91.725  95.347  105.480 1.00 24.75 ? 648 TYR A C     1 
ATOM   4558 O  O     . TYR A 1 648 ? 90.877  94.522  105.124 1.00 24.75 ? 648 TYR A O     1 
ATOM   4559 C  CB    . TYR A 1 648 ? 91.726  97.681  104.579 1.00 24.75 ? 648 TYR A CB    1 
ATOM   4560 C  CG    . TYR A 1 648 ? 91.119  97.278  103.254 1.00 24.75 ? 648 TYR A CG    1 
ATOM   4561 C  CD1   . TYR A 1 648 ? 91.768  96.385  102.414 1.00 24.75 ? 648 TYR A CD1   1 
ATOM   4562 C  CD2   . TYR A 1 648 ? 89.897  97.782  102.846 1.00 24.75 ? 648 TYR A CD2   1 
ATOM   4563 C  CE1   . TYR A 1 648 ? 91.221  96.012  101.204 1.00 24.75 ? 648 TYR A CE1   1 
ATOM   4564 C  CE2   . TYR A 1 648 ? 89.342  97.417  101.637 1.00 24.75 ? 648 TYR A CE2   1 
ATOM   4565 C  CZ    . TYR A 1 648 ? 90.008  96.532  100.821 1.00 24.75 ? 648 TYR A CZ    1 
ATOM   4566 O  OH    . TYR A 1 648 ? 89.458  96.164  99.616  1.00 24.75 ? 648 TYR A OH    1 
ATOM   4567 N  N     . PHE A 1 649 ? 93.004  95.017  105.645 1.00 24.72 ? 649 PHE A N     1 
ATOM   4568 C  CA    . PHE A 1 649 ? 93.521  93.698  105.308 1.00 24.72 ? 649 PHE A CA    1 
ATOM   4569 C  C     . PHE A 1 649 ? 93.479  92.748  106.496 1.00 24.72 ? 649 PHE A C     1 
ATOM   4570 O  O     . PHE A 1 649 ? 94.365  91.900  106.644 1.00 24.72 ? 649 PHE A O     1 
ATOM   4571 C  CB    . PHE A 1 649 ? 94.945  93.805  104.762 1.00 24.72 ? 649 PHE A CB    1 
ATOM   4572 C  CG    . PHE A 1 649 ? 95.061  94.647  103.523 1.00 24.72 ? 649 PHE A CG    1 
ATOM   4573 C  CD1   . PHE A 1 649 ? 94.586  94.188  102.309 1.00 24.72 ? 649 PHE A CD1   1 
ATOM   4574 C  CD2   . PHE A 1 649 ? 95.653  95.897  103.571 1.00 24.72 ? 649 PHE A CD2   1 
ATOM   4575 C  CE1   . PHE A 1 649 ? 94.691  94.959  101.176 1.00 24.72 ? 649 PHE A CE1   1 
ATOM   4576 C  CE2   . PHE A 1 649 ? 95.761  96.671  102.437 1.00 24.72 ? 649 PHE A CE2   1 
ATOM   4577 C  CZ    . PHE A 1 649 ? 95.280  96.201  101.241 1.00 24.72 ? 649 PHE A CZ    1 
ATOM   4578 N  N     . ASP A 1 650 ? 92.467  92.885  107.354 1.00 29.74 ? 650 ASP A N     1 
ATOM   4579 C  CA    . ASP A 1 650 ? 92.394  92.078  108.568 1.00 29.74 ? 650 ASP A CA    1 
ATOM   4580 C  C     . ASP A 1 650 ? 92.268  90.595  108.243 1.00 29.74 ? 650 ASP A C     1 
ATOM   4581 O  O     . ASP A 1 650 ? 92.890  89.753  108.900 1.00 29.74 ? 650 ASP A O     1 
ATOM   4582 C  CB    . ASP A 1 650 ? 91.219  92.544  109.427 1.00 29.74 ? 650 ASP A CB    1 
ATOM   4583 C  CG    . ASP A 1 650 ? 91.363  92.147  110.880 1.00 29.74 ? 650 ASP A CG    1 
ATOM   4584 O  OD1   . ASP A 1 650 ? 92.112  91.193  111.174 1.00 29.74 ? 650 ASP A OD1   1 
ATOM   4585 O  OD2   . ASP A 1 650 ? 90.726  92.798  111.734 1.00 29.74 ? 650 ASP A OD2   1 
ATOM   4586 N  N     . ASP A 1 651 ? 91.469  90.255  107.234 1.00 32.89 ? 651 ASP A N     1 
ATOM   4587 C  CA    . ASP A 1 651 ? 91.269  88.863  106.855 1.00 32.89 ? 651 ASP A CA    1 
ATOM   4588 C  C     . ASP A 1 651 ? 92.342  88.337  105.909 1.00 32.89 ? 651 ASP A C     1 
ATOM   4589 O  O     . ASP A 1 651 ? 92.346  87.138  105.614 1.00 32.89 ? 651 ASP A O     1 
ATOM   4590 C  CB    . ASP A 1 651 ? 89.897  88.691  106.206 1.00 32.89 ? 651 ASP A CB    1 
ATOM   4591 C  CG    . ASP A 1 651 ? 89.717  89.573  104.990 1.00 32.89 ? 651 ASP A CG    1 
ATOM   4592 O  OD1   . ASP A 1 651 ? 89.526  89.028  103.883 1.00 32.89 ? 651 ASP A OD1   1 
ATOM   4593 O  OD2   . ASP A 1 651 ? 89.768  90.812  105.139 1.00 32.89 ? 651 ASP A OD2   1 
ATOM   4594 N  N     . CYS A 1 652 ? 93.241  89.192  105.431 1.00 32.29 ? 652 CYS A N     1 
ATOM   4595 C  CA    . CYS A 1 652 ? 94.272  88.757  104.505 1.00 32.29 ? 652 CYS A CA    1 
ATOM   4596 C  C     . CYS A 1 652 ? 95.356  87.971  105.237 1.00 32.29 ? 652 CYS A C     1 
ATOM   4597 O  O     . CYS A 1 652 ? 95.385  87.884  106.466 1.00 32.29 ? 652 CYS A O     1 
ATOM   4598 C  CB    . CYS A 1 652 ? 94.885  89.954  103.783 1.00 32.29 ? 652 CYS A CB    1 
ATOM   4599 S  SG    . CYS A 1 652 ? 93.782  90.746  102.601 1.00 32.29 ? 652 CYS A SG    1 
ATOM   4600 N  N     . ASP A 1 653 ? 96.249  87.379  104.456 1.00 29.45 ? 653 ASP A N     1 
ATOM   4601 C  CA    . ASP A 1 653 ? 97.398  86.659  104.982 1.00 29.45 ? 653 ASP A CA    1 
ATOM   4602 C  C     . ASP A 1 653 ? 98.715  87.353  104.684 1.00 29.45 ? 653 ASP A C     1 
ATOM   4603 O  O     . ASP A 1 653 ? 99.590  87.399  105.550 1.00 29.45 ? 653 ASP A O     1 
ATOM   4604 C  CB    . ASP A 1 653 ? 97.440  85.235  104.411 1.00 29.45 ? 653 ASP A CB    1 
ATOM   4605 C  CG    . ASP A 1 653 ? 96.229  84.413  104.802 1.00 29.45 ? 653 ASP A CG    1 
ATOM   4606 O  OD1   . ASP A 1 653 ? 95.255  84.994  105.321 1.00 29.45 ? 653 ASP A OD1   1 
ATOM   4607 O  OD2   . ASP A 1 653 ? 96.247  83.183  104.588 1.00 29.45 ? 653 ASP A OD2   1 
ATOM   4608 N  N     . ILE A 1 654 ? 98.875  87.894  103.477 1.00 24.36 ? 654 ILE A N     1 
ATOM   4609 C  CA    . ILE A 1 654 ? 100.086 88.586  103.052 1.00 24.36 ? 654 ILE A CA    1 
ATOM   4610 C  C     . ILE A 1 654 ? 99.671  89.894  102.394 1.00 24.36 ? 654 ILE A C     1 
ATOM   4611 O  O     . ILE A 1 654 ? 98.607  89.972  101.772 1.00 24.36 ? 654 ILE A O     1 
ATOM   4612 C  CB    . ILE A 1 654 ? 100.919 87.734  102.069 1.00 24.36 ? 654 ILE A CB    1 
ATOM   4613 C  CG1   . ILE A 1 654 ? 101.092 86.308  102.588 1.00 24.36 ? 654 ILE A CG1   1 
ATOM   4614 C  CG2   . ILE A 1 654 ? 102.278 88.356  101.840 1.00 24.36 ? 654 ILE A CG2   1 
ATOM   4615 C  CD1   . ILE A 1 654 ? 101.959 86.198  103.810 1.00 24.36 ? 654 ILE A CD1   1 
ATOM   4616 N  N     . VAL A 1 655 ? 100.497 90.925  102.541 1.00 21.60 ? 655 VAL A N     1 
ATOM   4617 C  CA    . VAL A 1 655 ? 100.297 92.198  101.860 1.00 21.60 ? 655 VAL A CA    1 
ATOM   4618 C  C     . VAL A 1 655 ? 101.603 92.582  101.178 1.00 21.60 ? 655 VAL A C     1 
ATOM   4619 O  O     . VAL A 1 655 ? 102.688 92.319  101.706 1.00 21.60 ? 655 VAL A O     1 
ATOM   4620 C  CB    . VAL A 1 655 ? 99.830  93.304  102.830 1.00 21.60 ? 655 VAL A CB    1 
ATOM   4621 C  CG1   . VAL A 1 655 ? 99.434  94.555  102.071 1.00 21.60 ? 655 VAL A CG1   1 
ATOM   4622 C  CG2   . VAL A 1 655 ? 98.669  92.816  103.666 1.00 21.60 ? 655 VAL A CG2   1 
ATOM   4623 N  N     . PHE A 1 656 ? 101.499 93.187  99.996  1.00 21.94 ? 656 PHE A N     1 
ATOM   4624 C  CA    . PHE A 1 656 ? 102.653 93.560  99.188  1.00 21.94 ? 656 PHE A CA    1 
ATOM   4625 C  C     . PHE A 1 656 ? 102.811 95.074  99.167  1.00 21.94 ? 656 PHE A C     1 
ATOM   4626 O  O     . PHE A 1 656 ? 101.846 95.801  98.914  1.00 21.94 ? 656 PHE A O     1 
ATOM   4627 C  CB    . PHE A 1 656 ? 102.515 93.026  97.761  1.00 21.94 ? 656 PHE A CB    1 
ATOM   4628 C  CG    . PHE A 1 656 ? 102.539 91.533  97.673  1.00 21.94 ? 656 PHE A CG    1 
ATOM   4629 C  CD1   . PHE A 1 656 ? 103.662 90.823  98.049  1.00 21.94 ? 656 PHE A CD1   1 
ATOM   4630 C  CD2   . PHE A 1 656 ? 101.437 90.836  97.223  1.00 21.94 ? 656 PHE A CD2   1 
ATOM   4631 C  CE1   . PHE A 1 656 ? 103.685 89.447  97.975  1.00 21.94 ? 656 PHE A CE1   1 
ATOM   4632 C  CE2   . PHE A 1 656 ? 101.456 89.461  97.146  1.00 21.94 ? 656 PHE A CE2   1 
ATOM   4633 C  CZ    . PHE A 1 656 ? 102.582 88.767  97.523  1.00 21.94 ? 656 PHE A CZ    1 
ATOM   4634 N  N     . PHE A 1 657 ? 104.031 95.538  99.432  1.00 25.96 ? 657 PHE A N     1 
ATOM   4635 C  CA    . PHE A 1 657 ? 104.394 96.947  99.389  1.00 25.96 ? 657 PHE A CA    1 
ATOM   4636 C  C     . PHE A 1 657 ? 105.639 97.107  98.530  1.00 25.96 ? 657 PHE A C     1 
ATOM   4637 O  O     . PHE A 1 657 ? 106.510 96.236  98.529  1.00 25.96 ? 657 PHE A O     1 
ATOM   4638 C  CB    . PHE A 1 657 ? 104.657 97.501  100.798 1.00 25.96 ? 657 PHE A CB    1 
ATOM   4639 C  CG    . PHE A 1 657 ? 103.414 97.737  101.603 1.00 25.96 ? 657 PHE A CG    1 
ATOM   4640 C  CD1   . PHE A 1 657 ? 102.672 98.889  101.432 1.00 25.96 ? 657 PHE A CD1   1 
ATOM   4641 C  CD2   . PHE A 1 657 ? 102.981 96.803  102.523 1.00 25.96 ? 657 PHE A CD2   1 
ATOM   4642 C  CE1   . PHE A 1 657 ? 101.531 99.108  102.167 1.00 25.96 ? 657 PHE A CE1   1 
ATOM   4643 C  CE2   . PHE A 1 657 ? 101.840 97.017  103.258 1.00 25.96 ? 657 PHE A CE2   1 
ATOM   4644 C  CZ    . PHE A 1 657 ? 101.114 98.170  103.077 1.00 25.96 ? 657 PHE A CZ    1 
ATOM   4645 N  N     . GLU A 1 658 ? 105.723 98.212  97.796  1.00 35.16 ? 658 GLU A N     1 
ATOM   4646 C  CA    . GLU A 1 658 ? 106.910 98.466  96.992  1.00 35.16 ? 658 GLU A CA    1 
ATOM   4647 C  C     . GLU A 1 658 ? 108.074 98.883  97.882  1.00 35.16 ? 658 GLU A C     1 
ATOM   4648 O  O     . GLU A 1 658 ? 107.894 99.582  98.881  1.00 35.16 ? 658 GLU A O     1 
ATOM   4649 C  CB    . GLU A 1 658 ? 106.635 99.542  95.945  1.00 35.16 ? 658 GLU A CB    1 
ATOM   4650 C  CG    . GLU A 1 658 ? 105.909 100.755 96.477  1.00 35.16 ? 658 GLU A CG    1 
ATOM   4651 C  CD    . GLU A 1 658 ? 105.658 101.790 95.404  1.00 35.16 ? 658 GLU A CD    1 
ATOM   4652 O  OE1   . GLU A 1 658 ? 106.192 101.629 94.288  1.00 35.16 ? 658 GLU A OE1   1 
ATOM   4653 O  OE2   . GLU A 1 658 ? 104.921 102.760 95.673  1.00 35.16 ? 658 GLU A OE2   1 
ATOM   4654 N  N     . ASP A 1 659 ? 109.275 98.451  97.511  1.00 39.87 ? 659 ASP A N     1 
ATOM   4655 C  CA    . ASP A 1 659 ? 110.470 98.694  98.315  1.00 39.87 ? 659 ASP A CA    1 
ATOM   4656 C  C     . ASP A 1 659 ? 110.823 100.170 98.242  1.00 39.87 ? 659 ASP A C     1 
ATOM   4657 O  O     . ASP A 1 659 ? 111.452 100.626 97.287  1.00 39.87 ? 659 ASP A O     1 
ATOM   4658 C  CB    . ASP A 1 659 ? 111.626 97.832  97.825  1.00 39.87 ? 659 ASP A CB    1 
ATOM   4659 C  CG    . ASP A 1 659 ? 112.695 97.644  98.876  1.00 39.87 ? 659 ASP A CG    1 
ATOM   4660 O  OD1   . ASP A 1 659 ? 113.001 96.482  99.214  1.00 39.87 ? 659 ASP A OD1   1 
ATOM   4661 O  OD2   . ASP A 1 659 ? 113.230 98.659  99.367  1.00 39.87 ? 659 ASP A OD2   1 
ATOM   4662 N  N     . LEU A 1 660 ? 110.416 100.926 99.255  1.00 40.79 ? 660 LEU A N     1 
ATOM   4663 C  CA    . LEU A 1 660 ? 110.698 102.358 99.317  1.00 40.79 ? 660 LEU A CA    1 
ATOM   4664 C  C     . LEU A 1 660 ? 112.002 102.634 100.060 1.00 40.79 ? 660 LEU A C     1 
ATOM   4665 O  O     . LEU A 1 660 ? 112.067 103.469 100.960 1.00 40.79 ? 660 LEU A O     1 
ATOM   4666 C  CB    . LEU A 1 660 ? 109.525 103.078 99.968  1.00 40.79 ? 660 LEU A CB    1 
ATOM   4667 C  CG    . LEU A 1 660 ? 108.201 102.823 99.246  1.00 40.79 ? 660 LEU A CG    1 
ATOM   4668 C  CD1   . LEU A 1 660 ? 107.022 103.341 100.047 1.00 40.79 ? 660 LEU A CD1   1 
ATOM   4669 C  CD2   . LEU A 1 660 ? 108.232 103.456 97.866  1.00 40.79 ? 660 LEU A CD2   1 
ATOM   4670 N  N     . ASP A 1 661 ? 113.053 101.926 99.655  1.00 47.61 ? 661 ASP A N     1 
ATOM   4671 C  CA    . ASP A 1 661 ? 114.392 102.061 100.224 1.00 47.61 ? 661 ASP A CA    1 
ATOM   4672 C  C     . ASP A 1 661 ? 114.393 102.051 101.751 1.00 47.61 ? 661 ASP A C     1 
ATOM   4673 O  O     . ASP A 1 661 ? 115.430 101.834 102.378 1.00 47.61 ? 661 ASP A O     1 
ATOM   4674 C  CB    . ASP A 1 661 ? 115.053 103.339 99.710  1.00 47.61 ? 661 ASP A CB    1 
ATOM   4675 C  CG    . ASP A 1 661 ? 115.684 103.155 98.344  1.00 47.61 ? 661 ASP A CG    1 
ATOM   4676 O  OD1   . ASP A 1 661 ? 116.141 102.032 98.047  1.00 47.61 ? 661 ASP A OD1   1 
ATOM   4677 O  OD2   . ASP A 1 661 ? 115.723 104.132 97.568  1.00 47.61 ? 661 ASP A OD2   1 
ATOM   4678 N  N     . ASN A 1 671 ? 109.001 109.470 95.789  1.00 27.71 ? 671 ASN A N     1 
ATOM   4679 C  CA    . ASN A 1 671 ? 107.642 109.610 96.298  1.00 27.71 ? 671 ASN A CA    1 
ATOM   4680 C  C     . ASN A 1 671 ? 107.561 110.756 97.297  1.00 27.71 ? 671 ASN A C     1 
ATOM   4681 O  O     . ASN A 1 671 ? 108.390 110.866 98.196  1.00 27.71 ? 671 ASN A O     1 
ATOM   4682 C  CB    . ASN A 1 671 ? 107.177 108.304 96.941  1.00 27.71 ? 671 ASN A CB    1 
ATOM   4683 C  CG    . ASN A 1 671 ? 105.669 108.169 96.964  1.00 27.71 ? 671 ASN A CG    1 
ATOM   4684 O  OD1   . ASN A 1 671 ? 104.945 109.079 96.564  1.00 27.71 ? 671 ASN A OD1   1 
ATOM   4685 N  ND2   . ASN A 1 671 ? 105.187 107.024 97.430  1.00 27.71 ? 671 ASN A ND2   1 
ATOM   4686 N  N     . ALA A 1 672 ? 106.550 111.610 97.133  1.00 23.91 ? 672 ALA A N     1 
ATOM   4687 C  CA    . ALA A 1 672 ? 106.440 112.803 97.961  1.00 23.91 ? 672 ALA A CA    1 
ATOM   4688 C  C     . ALA A 1 672 ? 105.996 112.497 99.383  1.00 23.91 ? 672 ALA A C     1 
ATOM   4689 O  O     . ALA A 1 672 ? 106.139 113.356 100.258 1.00 23.91 ? 672 ALA A O     1 
ATOM   4690 C  CB    . ALA A 1 672 ? 105.473 113.797 97.322  1.00 23.91 ? 672 ALA A CB    1 
ATOM   4691 N  N     . LEU A 1 673 ? 105.458 111.306 99.634  1.00 23.50 ? 673 LEU A N     1 
ATOM   4692 C  CA    . LEU A 1 673 ? 104.997 110.946 100.966 1.00 23.50 ? 673 LEU A CA    1 
ATOM   4693 C  C     . LEU A 1 673 ? 106.030 110.172 101.766 1.00 23.50 ? 673 LEU A C     1 
ATOM   4694 O  O     . LEU A 1 673 ? 106.057 110.294 102.994 1.00 23.50 ? 673 LEU A O     1 
ATOM   4695 C  CB    . LEU A 1 673 ? 103.699 110.137 100.867 1.00 23.50 ? 673 LEU A CB    1 
ATOM   4696 C  CG    . LEU A 1 673 ? 102.926 109.775 102.135 1.00 23.50 ? 673 LEU A CG    1 
ATOM   4697 C  CD1   . LEU A 1 673 ? 101.483 109.661 101.788 1.00 23.50 ? 673 LEU A CD1   1 
ATOM   4698 C  CD2   . LEU A 1 673 ? 103.386 108.445 102.697 1.00 23.50 ? 673 LEU A CD2   1 
ATOM   4699 N  N     . VAL A 1 674 ? 106.875 109.384 101.108 1.00 25.96 ? 674 VAL A N     1 
ATOM   4700 C  CA    . VAL A 1 674 ? 107.903 108.644 101.827 1.00 25.96 ? 674 VAL A CA    1 
ATOM   4701 C  C     . VAL A 1 674 ? 108.940 109.588 102.422 1.00 25.96 ? 674 VAL A C     1 
ATOM   4702 O  O     . VAL A 1 674 ? 109.464 109.334 103.510 1.00 25.96 ? 674 VAL A O     1 
ATOM   4703 C  CB    . VAL A 1 674 ? 108.546 107.607 100.896 1.00 25.96 ? 674 VAL A CB    1 
ATOM   4704 C  CG1   . VAL A 1 674 ? 109.418 106.657 101.683 1.00 25.96 ? 674 VAL A CG1   1 
ATOM   4705 C  CG2   . VAL A 1 674 ? 107.471 106.846 100.158 1.00 25.96 ? 674 VAL A CG2   1 
ATOM   4706 N  N     . LYS A 1 675 ? 109.257 110.678 101.731 1.00 22.56 ? 675 LYS A N     1 
ATOM   4707 C  CA    . LYS A 1 675 ? 110.152 111.692 102.266 1.00 22.56 ? 675 LYS A CA    1 
ATOM   4708 C  C     . LYS A 1 675 ? 109.488 112.578 103.311 1.00 22.56 ? 675 LYS A C     1 
ATOM   4709 O  O     . LYS A 1 675 ? 110.194 113.243 104.074 1.00 22.56 ? 675 LYS A O     1 
ATOM   4710 C  CB    . LYS A 1 675 ? 110.695 112.564 101.131 1.00 22.56 ? 675 LYS A CB    1 
ATOM   4711 C  CG    . LYS A 1 675 ? 109.804 113.741 100.776 1.00 22.56 ? 675 LYS A CG    1 
ATOM   4712 C  CD    . LYS A 1 675 ? 110.406 114.572 99.657  1.00 22.56 ? 675 LYS A CD    1 
ATOM   4713 C  CE    . LYS A 1 675 ? 110.279 113.862 98.320  1.00 22.56 ? 675 LYS A CE    1 
ATOM   4714 N  NZ    . LYS A 1 675 ? 110.278 114.817 97.181  1.00 22.56 ? 675 LYS A NZ    1 
ATOM   4715 N  N     . LEU A 1 676 ? 108.156 112.602 103.367 1.00 18.81 ? 676 LEU A N     1 
ATOM   4716 C  CA    . LEU A 1 676 ? 107.463 113.408 104.366 1.00 18.81 ? 676 LEU A CA    1 
ATOM   4717 C  C     . LEU A 1 676 ? 107.462 112.723 105.726 1.00 18.81 ? 676 LEU A C     1 
ATOM   4718 O  O     . LEU A 1 676 ? 107.861 113.320 106.730 1.00 18.81 ? 676 LEU A O     1 
ATOM   4719 C  CB    . LEU A 1 676 ? 106.035 113.706 103.906 1.00 18.81 ? 676 LEU A CB    1 
ATOM   4720 C  CG    . LEU A 1 676 ? 105.015 114.142 104.956 1.00 18.81 ? 676 LEU A CG    1 
ATOM   4721 C  CD1   . LEU A 1 676 ? 105.500 115.341 105.735 1.00 18.81 ? 676 LEU A CD1   1 
ATOM   4722 C  CD2   . LEU A 1 676 ? 103.698 114.460 104.280 1.00 18.81 ? 676 LEU A CD2   1 
ATOM   4723 N  N     . LEU A 1 677 ? 107.009 111.472 105.786 1.00 19.65 ? 677 LEU A N     1 
ATOM   4724 C  CA    . LEU A 1 677 ? 106.969 110.787 107.076 1.00 19.65 ? 677 LEU A CA    1 
ATOM   4725 C  C     . LEU A 1 677 ? 108.356 110.276 107.448 1.00 19.65 ? 677 LEU A C     1 
ATOM   4726 O  O     . LEU A 1 677 ? 108.990 110.795 108.370 1.00 19.65 ? 677 LEU A O     1 
ATOM   4727 C  CB    . LEU A 1 677 ? 105.941 109.652 107.036 1.00 19.65 ? 677 LEU A CB    1 
ATOM   4728 C  CG    . LEU A 1 677 ? 104.495 110.116 106.824 1.00 19.65 ? 677 LEU A CG    1 
ATOM   4729 C  CD1   . LEU A 1 677 ? 103.563 108.944 106.596 1.00 19.65 ? 677 LEU A CD1   1 
ATOM   4730 C  CD2   . LEU A 1 677 ? 104.017 110.965 107.987 1.00 19.65 ? 677 LEU A CD2   1 
ATOM   4731 N  N     . SER A 1 678 ? 108.851 109.282 106.713 1.00 26.20 ? 678 SER A N     1 
ATOM   4732 C  CA    . SER A 1 678 ? 110.230 108.806 106.770 1.00 26.20 ? 678 SER A CA    1 
ATOM   4733 C  C     . SER A 1 678 ? 110.390 107.659 105.780 1.00 26.20 ? 678 SER A C     1 
ATOM   4734 O  O     . SER A 1 678 ? 109.424 106.935 105.513 1.00 26.20 ? 678 SER A O     1 
ATOM   4735 C  CB    . SER A 1 678 ? 110.614 108.345 108.176 1.00 26.20 ? 678 SER A CB    1 
ATOM   4736 O  OG    . SER A 1 678 ? 111.942 107.858 108.213 1.00 26.20 ? 678 SER A OG    1 
ATOM   4737 N  N     . PRO A 1 679 ? 111.575 107.448 105.226 1.00 31.28 ? 679 PRO A N     1 
ATOM   4738 C  CA    . PRO A 1 679 ? 111.750 106.310 104.314 1.00 31.28 ? 679 PRO A CA    1 
ATOM   4739 C  C     . PRO A 1 679 ? 111.992 105.003 105.052 1.00 31.28 ? 679 PRO A C     1 
ATOM   4740 O  O     . PRO A 1 679 ? 111.853 103.925 104.468 1.00 31.28 ? 679 PRO A O     1 
ATOM   4741 C  CB    . PRO A 1 679 ? 112.964 106.706 103.463 1.00 31.28 ? 679 PRO A CB    1 
ATOM   4742 C  CG    . PRO A 1 679 ? 113.613 107.836 104.156 1.00 31.28 ? 679 PRO A CG    1 
ATOM   4743 C  CD    . PRO A 1 679 ? 112.692 108.406 105.178 1.00 31.28 ? 679 PRO A CD    1 
ATOM   4744 N  N     . ARG A 1 680 ? 112.347 105.078 106.332 1.00 33.58 ? 680 ARG A N     1 
ATOM   4745 C  CA    . ARG A 1 680 ? 112.698 103.888 107.093 1.00 33.58 ? 680 ARG A CA    1 
ATOM   4746 C  C     . ARG A 1 680 ? 111.731 103.560 108.217 1.00 33.58 ? 680 ARG A C     1 
ATOM   4747 O  O     . ARG A 1 680 ? 111.578 102.385 108.548 1.00 33.58 ? 680 ARG A O     1 
ATOM   4748 C  CB    . ARG A 1 680 ? 114.107 104.026 107.685 1.00 33.58 ? 680 ARG A CB    1 
ATOM   4749 C  CG    . ARG A 1 680 ? 114.873 102.713 107.753 1.00 33.58 ? 680 ARG A CG    1 
ATOM   4750 C  CD    . ARG A 1 680 ? 116.006 102.765 108.774 1.00 33.58 ? 680 ARG A CD    1 
ATOM   4751 N  NE    . ARG A 1 680 ? 115.542 102.722 110.158 1.00 33.58 ? 680 ARG A NE    1 
ATOM   4752 C  CZ    . ARG A 1 680 ? 114.864 101.721 110.709 1.00 33.58 ? 680 ARG A CZ    1 
ATOM   4753 N  NH1   . ARG A 1 680 ? 114.581 100.618 110.035 1.00 33.58 ? 680 ARG A NH1   1 
ATOM   4754 N  NH2   . ARG A 1 680 ? 114.469 101.826 111.975 1.00 33.58 ? 680 ARG A NH2   1 
ATOM   4755 N  N     . THR A 1 681 ? 111.078 104.557 108.812 1.00 20.93 ? 681 THR A N     1 
ATOM   4756 C  CA    . THR A 1 681 ? 110.195 104.312 109.945 1.00 20.93 ? 681 THR A CA    1 
ATOM   4757 C  C     . THR A 1 681 ? 108.748 104.070 109.547 1.00 20.93 ? 681 THR A C     1 
ATOM   4758 O  O     . THR A 1 681 ? 108.041 103.352 110.258 1.00 20.93 ? 681 THR A O     1 
ATOM   4759 C  CB    . THR A 1 681 ? 110.243 105.483 110.931 1.00 20.93 ? 681 THR A CB    1 
ATOM   4760 O  OG1   . THR A 1 681 ? 109.396 106.537 110.461 1.00 20.93 ? 681 THR A OG1   1 
ATOM   4761 C  CG2   . THR A 1 681 ? 111.658 106.005 111.072 1.00 20.93 ? 681 THR A CG2   1 
ATOM   4762 N  N     . LEU A 1 682 ? 108.283 104.650 108.439 1.00 17.55 ? 682 LEU A N     1 
ATOM   4763 C  CA    . LEU A 1 682 ? 106.922 104.378 107.990 1.00 17.55 ? 682 LEU A CA    1 
ATOM   4764 C  C     . LEU A 1 682 ? 106.739 102.901 107.668 1.00 17.55 ? 682 LEU A C     1 
ATOM   4765 O  O     . LEU A 1 682 ? 105.731 102.292 108.049 1.00 17.55 ? 682 LEU A O     1 
ATOM   4766 C  CB    . LEU A 1 682 ? 106.592 105.242 106.776 1.00 17.55 ? 682 LEU A CB    1 
ATOM   4767 C  CG    . LEU A 1 682 ? 105.236 105.010 106.114 1.00 17.55 ? 682 LEU A CG    1 
ATOM   4768 C  CD1   . LEU A 1 682 ? 104.109 105.209 107.111 1.00 17.55 ? 682 LEU A CD1   1 
ATOM   4769 C  CD2   . LEU A 1 682 ? 105.067 105.930 104.919 1.00 17.55 ? 682 LEU A CD2   1 
ATOM   4770 N  N     . LEU A 1 683 ? 107.713 102.305 106.982 1.00 16.70 ? 683 LEU A N     1 
ATOM   4771 C  CA    . LEU A 1 683 ? 107.692 100.869 106.744 1.00 16.70 ? 683 LEU A CA    1 
ATOM   4772 C  C     . LEU A 1 683 ? 107.749 100.081 108.041 1.00 16.70 ? 683 LEU A C     1 
ATOM   4773 O  O     . LEU A 1 683 ? 107.060 99.064  108.166 1.00 16.70 ? 683 LEU A O     1 
ATOM   4774 C  CB    . LEU A 1 683 ? 108.859 100.472 105.840 1.00 16.70 ? 683 LEU A CB    1 
ATOM   4775 C  CG    . LEU A 1 683 ? 108.755 100.866 104.366 1.00 16.70 ? 683 LEU A CG    1 
ATOM   4776 C  CD1   . LEU A 1 683 ? 109.802 100.136 103.554 1.00 16.70 ? 683 LEU A CD1   1 
ATOM   4777 C  CD2   . LEU A 1 683 ? 107.365 100.583 103.818 1.00 16.70 ? 683 LEU A CD2   1 
ATOM   4778 N  N     . LEU A 1 684 ? 108.543 100.536 109.009 1.00 16.35 ? 684 LEU A N     1 
ATOM   4779 C  CA    . LEU A 1 684 ? 108.625 99.879  110.307 1.00 16.35 ? 684 LEU A CA    1 
ATOM   4780 C  C     . LEU A 1 684 ? 107.291 99.913  111.045 1.00 16.35 ? 684 LEU A C     1 
ATOM   4781 O  O     . LEU A 1 684 ? 106.874 98.905  111.625 1.00 16.35 ? 684 LEU A O     1 
ATOM   4782 C  CB    . LEU A 1 684 ? 109.720 100.541 111.139 1.00 16.35 ? 684 LEU A CB    1 
ATOM   4783 C  CG    . LEU A 1 684 ? 109.826 100.184 112.613 1.00 16.35 ? 684 LEU A CG    1 
ATOM   4784 C  CD1   . LEU A 1 684 ? 110.490 98.833  112.781 1.00 16.35 ? 684 LEU A CD1   1 
ATOM   4785 C  CD2   . LEU A 1 684 ? 110.597 101.266 113.342 1.00 16.35 ? 684 LEU A CD2   1 
ATOM   4786 N  N     . TYR A 1 685 ? 106.604 101.053 111.027 1.00 20.29 ? 685 TYR A N     1 
ATOM   4787 C  CA    . TYR A 1 685 ? 105.304 101.146 111.683 1.00 20.29 ? 685 TYR A CA    1 
ATOM   4788 C  C     . TYR A 1 685 ? 104.255 100.293 110.985 1.00 20.29 ? 685 TYR A C     1 
ATOM   4789 O  O     . TYR A 1 685 ? 103.438 99.646  111.650 1.00 20.29 ? 685 TYR A O     1 
ATOM   4790 C  CB    . TYR A 1 685 ? 104.847 102.599 111.742 1.00 20.29 ? 685 TYR A CB    1 
ATOM   4791 C  CG    . TYR A 1 685 ? 105.560 103.412 112.788 1.00 20.29 ? 685 TYR A CG    1 
ATOM   4792 C  CD1   . TYR A 1 685 ? 106.631 102.891 113.498 1.00 20.29 ? 685 TYR A CD1   1 
ATOM   4793 C  CD2   . TYR A 1 685 ? 105.164 104.697 113.066 1.00 20.29 ? 685 TYR A CD2   1 
ATOM   4794 C  CE1   . TYR A 1 685 ? 107.281 103.639 114.449 1.00 20.29 ? 685 TYR A CE1   1 
ATOM   4795 C  CE2   . TYR A 1 685 ? 105.803 105.446 114.008 1.00 20.29 ? 685 TYR A CE2   1 
ATOM   4796 C  CZ    . TYR A 1 685 ? 106.860 104.917 114.698 1.00 20.29 ? 685 TYR A CZ    1 
ATOM   4797 O  OH    . TYR A 1 685 ? 107.495 105.680 115.646 1.00 20.29 ? 685 TYR A OH    1 
ATOM   4798 N  N     . ILE A 1 686 ? 104.250 100.290 109.650 1.00 13.44 ? 686 ILE A N     1 
ATOM   4799 C  CA    . ILE A 1 686 ? 103.321 99.430  108.924 1.00 13.44 ? 686 ILE A CA    1 
ATOM   4800 C  C     . ILE A 1 686 ? 103.581 97.971  109.269 1.00 13.44 ? 686 ILE A C     1 
ATOM   4801 O  O     . ILE A 1 686 ? 102.646 97.187  109.486 1.00 13.44 ? 686 ILE A O     1 
ATOM   4802 C  CB    . ILE A 1 686 ? 103.434 99.685  107.411 1.00 13.44 ? 686 ILE A CB    1 
ATOM   4803 C  CG1   . ILE A 1 686 ? 102.792 101.021 107.047 1.00 13.44 ? 686 ILE A CG1   1 
ATOM   4804 C  CG2   . ILE A 1 686 ? 102.766 98.575  106.632 1.00 13.44 ? 686 ILE A CG2   1 
ATOM   4805 C  CD1   . ILE A 1 686 ? 103.100 101.474 105.648 1.00 13.44 ? 686 ILE A CD1   1 
ATOM   4806 N  N     . ARG A 1 687 ? 104.857 97.586  109.331 1.00 18.62 ? 687 ARG A N     1 
ATOM   4807 C  CA    . ARG A 1 687 ? 105.210 96.213  109.667 1.00 18.62 ? 687 ARG A CA    1 
ATOM   4808 C  C     . ARG A 1 687 ? 104.748 95.852  111.071 1.00 18.62 ? 687 ARG A C     1 
ATOM   4809 O  O     . ARG A 1 687 ? 104.228 94.756  111.293 1.00 18.62 ? 687 ARG A O     1 
ATOM   4810 C  CB    . ARG A 1 687 ? 106.718 96.021  109.529 1.00 18.62 ? 687 ARG A CB    1 
ATOM   4811 C  CG    . ARG A 1 687 ? 107.190 94.612  109.788 1.00 18.62 ? 687 ARG A CG    1 
ATOM   4812 C  CD    . ARG A 1 687 ? 108.678 94.486  109.548 1.00 18.62 ? 687 ARG A CD    1 
ATOM   4813 N  NE    . ARG A 1 687 ? 109.015 94.612  108.136 1.00 18.62 ? 687 ARG A NE    1 
ATOM   4814 C  CZ    . ARG A 1 687 ? 109.105 93.593  107.293 1.00 18.62 ? 687 ARG A CZ    1 
ATOM   4815 N  NH1   . ARG A 1 687 ? 108.881 92.350  107.684 1.00 18.62 ? 687 ARG A NH1   1 
ATOM   4816 N  NH2   . ARG A 1 687 ? 109.428 93.827  106.024 1.00 18.62 ? 687 ARG A NH2   1 
ATOM   4817 N  N     . GLN A 1 688 ? 104.925 96.762  112.032 1.00 19.73 ? 688 GLN A N     1 
ATOM   4818 C  CA    . GLN A 1 688 ? 104.466 96.506  113.395 1.00 19.73 ? 688 GLN A CA    1 
ATOM   4819 C  C     . GLN A 1 688 ? 102.950 96.357  113.457 1.00 19.73 ? 688 GLN A C     1 
ATOM   4820 O  O     . GLN A 1 688 ? 102.436 95.445  114.116 1.00 19.73 ? 688 GLN A O     1 
ATOM   4821 C  CB    . GLN A 1 688 ? 104.925 97.631  114.320 1.00 19.73 ? 688 GLN A CB    1 
ATOM   4822 C  CG    . GLN A 1 688 ? 106.376 97.542  114.744 1.00 19.73 ? 688 GLN A CG    1 
ATOM   4823 C  CD    . GLN A 1 688 ? 106.864 98.812  115.408 1.00 19.73 ? 688 GLN A CD    1 
ATOM   4824 O  OE1   . GLN A 1 688 ? 106.096 99.746  115.624 1.00 19.73 ? 688 GLN A OE1   1 
ATOM   4825 N  NE2   . GLN A 1 688 ? 108.145 98.849  115.743 1.00 19.73 ? 688 GLN A NE2   1 
ATOM   4826 N  N     . ALA A 1 689 ? 102.217 97.242  112.777 1.00 16.50 ? 689 ALA A N     1 
ATOM   4827 C  CA    . ALA A 1 689 ? 100.760 97.167  112.805 1.00 16.50 ? 689 ALA A CA    1 
ATOM   4828 C  C     . ALA A 1 689 ? 100.260 95.860  112.206 1.00 16.50 ? 689 ALA A C     1 
ATOM   4829 O  O     . ALA A 1 689 ? 99.373  95.214  112.771 1.00 16.50 ? 689 ALA A O     1 
ATOM   4830 C  CB    . ALA A 1 689 ? 100.151 98.356  112.065 1.00 16.50 ? 689 ALA A CB    1 
ATOM   4831 N  N     . LEU A 1 690 ? 100.813 95.454  111.061 1.00 19.47 ? 690 LEU A N     1 
ATOM   4832 C  CA    . LEU A 1 690 ? 100.406 94.179  110.476 1.00 19.47 ? 690 LEU A CA    1 
ATOM   4833 C  C     . LEU A 1 690 ? 100.830 92.999  111.340 1.00 19.47 ? 690 LEU A C     1 
ATOM   4834 O  O     . LEU A 1 690 ? 100.069 92.037  111.485 1.00 19.47 ? 690 LEU A O     1 
ATOM   4835 C  CB    . LEU A 1 690 ? 100.975 94.033  109.066 1.00 19.47 ? 690 LEU A CB    1 
ATOM   4836 C  CG    . LEU A 1 690 ? 100.179 94.683  107.937 1.00 19.47 ? 690 LEU A CG    1 
ATOM   4837 C  CD1   . LEU A 1 690 ? 100.905 94.505  106.625 1.00 19.47 ? 690 LEU A CD1   1 
ATOM   4838 C  CD2   . LEU A 1 690 ? 98.795  94.077  107.860 1.00 19.47 ? 690 LEU A CD2   1 
ATOM   4839 N  N     . GLU A 1 691 ? 102.030 93.054  111.918 1.00 24.97 ? 691 GLU A N     1 
ATOM   4840 C  CA    . GLU A 1 691 ? 102.525 91.982  112.772 1.00 24.97 ? 691 GLU A CA    1 
ATOM   4841 C  C     . GLU A 1 691 ? 101.656 91.809  114.006 1.00 24.97 ? 691 GLU A C     1 
ATOM   4842 O  O     . GLU A 1 691 ? 101.551 90.702  114.543 1.00 24.97 ? 691 GLU A O     1 
ATOM   4843 C  CB    . GLU A 1 691 ? 103.968 92.298  113.161 1.00 24.97 ? 691 GLU A CB    1 
ATOM   4844 C  CG    . GLU A 1 691 ? 104.746 91.194  113.821 1.00 24.97 ? 691 GLU A CG    1 
ATOM   4845 C  CD    . GLU A 1 691 ? 106.237 91.464  113.774 1.00 24.97 ? 691 GLU A CD    1 
ATOM   4846 O  OE1   . GLU A 1 691 ? 106.729 92.235  114.624 1.00 24.97 ? 691 GLU A OE1   1 
ATOM   4847 O  OE2   . GLU A 1 691 ? 106.919 90.914  112.884 1.00 24.97 ? 691 GLU A OE2   1 
ATOM   4848 N  N     . LYS A 1 692 ? 101.020 92.890  114.460 1.00 26.49 ? 692 LYS A N     1 
ATOM   4849 C  CA    . LYS A 1 692 ? 100.096 92.824  115.586 1.00 26.49 ? 692 LYS A CA    1 
ATOM   4850 C  C     . LYS A 1 692 ? 98.995  91.791  115.385 1.00 26.49 ? 692 LYS A C     1 
ATOM   4851 O  O     . LYS A 1 692 ? 98.529  91.202  116.364 1.00 26.49 ? 692 LYS A O     1 
ATOM   4852 C  CB    . LYS A 1 692 ? 99.477  94.205  115.810 1.00 26.49 ? 692 LYS A CB    1 
ATOM   4853 C  CG    . LYS A 1 692 ? 98.505  94.299  116.963 1.00 26.49 ? 692 LYS A CG    1 
ATOM   4854 C  CD    . LYS A 1 692 ? 99.187  94.008  118.273 1.00 26.49 ? 692 LYS A CD    1 
ATOM   4855 C  CE    . LYS A 1 692 ? 100.155 95.098  118.661 1.00 26.49 ? 692 LYS A CE    1 
ATOM   4856 N  NZ    . LYS A 1 692 ? 100.762 94.808  119.983 1.00 26.49 ? 692 LYS A NZ    1 
ATOM   4857 N  N     . ARG A 1 693 ? 98.582  91.548  114.142 1.00 26.77 ? 693 ARG A N     1 
ATOM   4858 C  CA    . ARG A 1 693 ? 97.456  90.673  113.846 1.00 26.77 ? 693 ARG A CA    1 
ATOM   4859 C  C     . ARG A 1 693 ? 97.887  89.383  113.160 1.00 26.77 ? 693 ARG A C     1 
ATOM   4860 O  O     . ARG A 1 693 ? 97.045  88.669  112.609 1.00 26.77 ? 693 ARG A O     1 
ATOM   4861 C  CB    . ARG A 1 693 ? 96.433  91.416  112.991 1.00 26.77 ? 693 ARG A CB    1 
ATOM   4862 C  CG    . ARG A 1 693 ? 95.998  92.729  113.596 1.00 26.77 ? 693 ARG A CG    1 
ATOM   4863 C  CD    . ARG A 1 693 ? 94.657  93.165  113.060 1.00 26.77 ? 693 ARG A CD    1 
ATOM   4864 N  NE    . ARG A 1 693 ? 94.288  94.489  113.543 1.00 26.77 ? 693 ARG A NE    1 
ATOM   4865 C  CZ    . ARG A 1 693 ? 93.040  94.895  113.722 1.00 26.77 ? 693 ARG A CZ    1 
ATOM   4866 N  NH1   . ARG A 1 693 ? 92.013  94.102  113.470 1.00 26.77 ? 693 ARG A NH1   1 
ATOM   4867 N  NH2   . ARG A 1 693 ? 92.817  96.131  114.159 1.00 26.77 ? 693 ARG A NH2   1 
ATOM   4868 N  N     . GLY A 1 694 ? 99.176  89.062  113.188 1.00 25.84 ? 694 GLY A N     1 
ATOM   4869 C  CA    . GLY A 1 694 ? 99.654  87.852  112.551 1.00 25.84 ? 694 GLY A CA    1 
ATOM   4870 C  C     . GLY A 1 694 ? 99.519  87.869  111.044 1.00 25.84 ? 694 GLY A C     1 
ATOM   4871 O  O     . GLY A 1 694 ? 99.080  86.886  110.441 1.00 25.84 ? 694 GLY A O     1 
ATOM   4872 N  N     . ILE A 1 695 ? 99.891  88.986  110.425 1.00 24.20 ? 695 ILE A N     1 
ATOM   4873 C  CA    . ILE A 1 695 ? 99.856  89.155  108.978 1.00 24.20 ? 695 ILE A CA    1 
ATOM   4874 C  C     . ILE A 1 695 ? 101.265 89.476  108.503 1.00 24.20 ? 695 ILE A C     1 
ATOM   4875 O  O     . ILE A 1 695 ? 101.936 90.337  109.081 1.00 24.20 ? 695 ILE A O     1 
ATOM   4876 C  CB    . ILE A 1 695 ? 98.879  90.267  108.560 1.00 24.20 ? 695 ILE A CB    1 
ATOM   4877 C  CG1   . ILE A 1 695 ? 97.516  90.057  109.213 1.00 24.20 ? 695 ILE A CG1   1 
ATOM   4878 C  CG2   . ILE A 1 695 ? 98.737  90.308  107.058 1.00 24.20 ? 695 ILE A CG2   1 
ATOM   4879 C  CD1   . ILE A 1 695 ? 96.553  91.192  108.969 1.00 24.20 ? 695 ILE A CD1   1 
ATOM   4880 N  N     . GLY A 1 696 ? 101.716 88.782  107.462 1.00 19.65 ? 696 GLY A N     1 
ATOM   4881 C  CA    . GLY A 1 696 ? 103.024 89.053  106.906 1.00 19.65 ? 696 GLY A CA    1 
ATOM   4882 C  C     . GLY A 1 696 ? 103.029 90.255  105.980 1.00 19.65 ? 696 GLY A C     1 
ATOM   4883 O  O     . GLY A 1 696 ? 101.992 90.799  105.609 1.00 19.65 ? 696 GLY A O     1 
ATOM   4884 N  N     . MET A 1 697 ? 104.234 90.677  105.604 1.00 21.12 ? 697 MET A N     1 
ATOM   4885 C  CA    . MET A 1 697 ? 104.400 91.776  104.664 1.00 21.12 ? 697 MET A CA    1 
ATOM   4886 C  C     . MET A 1 697 ? 105.627 91.506  103.806 1.00 21.12 ? 697 MET A C     1 
ATOM   4887 O  O     . MET A 1 697 ? 106.649 91.035  104.308 1.00 21.12 ? 697 MET A O     1 
ATOM   4888 C  CB    . MET A 1 697 ? 104.539 93.123  105.382 1.00 21.12 ? 697 MET A CB    1 
ATOM   4889 C  CG    . MET A 1 697 ? 104.438 94.318  104.455 1.00 21.12 ? 697 MET A CG    1 
ATOM   4890 S  SD    . MET A 1 697 ? 105.018 95.866  105.165 1.00 21.12 ? 697 MET A SD    1 
ATOM   4891 C  CE    . MET A 1 697 ? 106.486 95.317  106.010 1.00 21.12 ? 697 MET A CE    1 
ATOM   4892 N  N     . VAL A 1 698 ? 105.517 91.806  102.513 1.00 23.22 ? 698 VAL A N     1 
ATOM   4893 C  CA    . VAL A 1 698 ? 106.568 91.530  101.541 1.00 23.22 ? 698 VAL A CA    1 
ATOM   4894 C  C     . VAL A 1 698 ? 106.837 92.799  100.746 1.00 23.22 ? 698 VAL A C     1 
ATOM   4895 O  O     . VAL A 1 698 ? 105.898 93.485  100.330 1.00 23.22 ? 698 VAL A O     1 
ATOM   4896 C  CB    . VAL A 1 698 ? 106.183 90.367  100.605 1.00 23.22 ? 698 VAL A CB    1 
ATOM   4897 C  CG1   . VAL A 1 698 ? 107.147 90.267  99.437  1.00 23.22 ? 698 VAL A CG1   1 
ATOM   4898 C  CG2   . VAL A 1 698 ? 106.146 89.060  101.378 1.00 23.22 ? 698 VAL A CG2   1 
ATOM   4899 N  N     . GLU A 1 699 ? 108.115 93.110  100.540 1.00 30.42 ? 699 GLU A N     1 
ATOM   4900 C  CA    . GLU A 1 699 ? 108.545 94.315  99.843  1.00 30.42 ? 699 GLU A CA    1 
ATOM   4901 C  C     . GLU A 1 699 ? 109.136 93.947  98.489  1.00 30.42 ? 699 GLU A C     1 
ATOM   4902 O  O     . GLU A 1 699 ? 110.079 93.154  98.412  1.00 30.42 ? 699 GLU A O     1 
ATOM   4903 C  CB    . GLU A 1 699 ? 109.565 95.081  100.682 1.00 30.42 ? 699 GLU A CB    1 
ATOM   4904 C  CG    . GLU A 1 699 ? 108.975 95.656  101.950 1.00 30.42 ? 699 GLU A CG    1 
ATOM   4905 C  CD    . GLU A 1 699 ? 109.992 96.392  102.785 1.00 30.42 ? 699 GLU A CD    1 
ATOM   4906 O  OE1   . GLU A 1 699 ? 111.191 96.352  102.440 1.00 30.42 ? 699 GLU A OE1   1 
ATOM   4907 O  OE2   . GLU A 1 699 ? 109.593 96.995  103.801 1.00 30.42 ? 699 GLU A OE2   1 
ATOM   4908 N  N     . VAL A 1 700 ? 108.591 94.540  97.427  1.00 31.97 ? 700 VAL A N     1 
ATOM   4909 C  CA    . VAL A 1 700 ? 108.935 94.184  96.058  1.00 31.97 ? 700 VAL A CA    1 
ATOM   4910 C  C     . VAL A 1 700 ? 109.611 95.370  95.383  1.00 31.97 ? 700 VAL A C     1 
ATOM   4911 O  O     . VAL A 1 700 ? 109.518 96.512  95.836  1.00 31.97 ? 700 VAL A O     1 
ATOM   4912 C  CB    . VAL A 1 700 ? 107.698 93.738  95.256  1.00 31.97 ? 700 VAL A CB    1 
ATOM   4913 C  CG1   . VAL A 1 700 ? 106.997 92.598  95.965  1.00 31.97 ? 700 VAL A CG1   1 
ATOM   4914 C  CG2   . VAL A 1 700 ? 106.751 94.904  95.055  1.00 31.97 ? 700 VAL A CG2   1 
ATOM   4915 N  N     . ALA A 1 701 ? 110.294 95.081  94.277  1.00 33.46 ? 701 ALA A N     1 
ATOM   4916 C  CA    . ALA A 1 701 ? 111.021 96.112  93.549  1.00 33.46 ? 701 ALA A CA    1 
ATOM   4917 C  C     . ALA A 1 701 ? 110.068 97.170  93.011  1.00 33.46 ? 701 ALA A C     1 
ATOM   4918 O  O     . ALA A 1 701 ? 109.007 96.857  92.469  1.00 33.46 ? 701 ALA A O     1 
ATOM   4919 C  CB    . ALA A 1 701 ? 111.811 95.489  92.401  1.00 33.46 ? 701 ALA A CB    1 
ATOM   4920 N  N     . LYS A 1 702 ? 110.459 98.432  93.150  1.00 35.42 ? 702 LYS A N     1 
ATOM   4921 C  CA    . LYS A 1 702 ? 109.607 99.554  92.783  1.00 35.42 ? 702 LYS A CA    1 
ATOM   4922 C  C     . LYS A 1 702 ? 109.848 100.061 91.369  1.00 35.42 ? 702 LYS A C     1 
ATOM   4923 O  O     . LYS A 1 702 ? 109.267 101.082 90.989  1.00 35.42 ? 702 LYS A O     1 
ATOM   4924 C  CB    . LYS A 1 702 ? 109.799 100.705 93.774  1.00 35.42 ? 702 LYS A CB    1 
ATOM   4925 C  CG    . LYS A 1 702 ? 111.150 101.387 93.695  1.00 35.42 ? 702 LYS A CG    1 
ATOM   4926 C  CD    . LYS A 1 702 ? 111.219 102.560 94.658  1.00 35.42 ? 702 LYS A CD    1 
ATOM   4927 C  CE    . LYS A 1 702 ? 112.524 103.323 94.525  1.00 35.42 ? 702 LYS A CE    1 
ATOM   4928 N  NZ    . LYS A 1 702 ? 113.694 102.517 94.962  1.00 35.42 ? 702 LYS A NZ    1 
ATOM   4929 N  N     . ASP A 1 703 ? 110.680 99.383  90.584  1.00 36.01 ? 703 ASP A N     1 
ATOM   4930 C  CA    . ASP A 1 703 ? 111.048 99.869  89.260  1.00 36.01 ? 703 ASP A CA    1 
ATOM   4931 C  C     . ASP A 1 703 ? 109.954 99.536  88.253  1.00 36.01 ? 703 ASP A C     1 
ATOM   4932 O  O     . ASP A 1 703 ? 109.610 98.365  88.065  1.00 36.01 ? 703 ASP A O     1 
ATOM   4933 C  CB    . ASP A 1 703 ? 112.377 99.258  88.829  1.00 36.01 ? 703 ASP A CB    1 
ATOM   4934 C  CG    . ASP A 1 703 ? 113.543 99.767  89.647  1.00 36.01 ? 703 ASP A CG    1 
ATOM   4935 O  OD1   . ASP A 1 703 ? 113.480 100.916 90.131  1.00 36.01 ? 703 ASP A OD1   1 
ATOM   4936 O  OD2   . ASP A 1 703 ? 114.523 99.014  89.815  1.00 36.01 ? 703 ASP A OD2   1 
ATOM   4937 N  N     . GLY A 1 704 ? 109.403 100.564 87.615  1.00 34.41 ? 704 GLY A N     1 
ATOM   4938 C  CA    . GLY A 1 704 ? 108.498 100.376 86.501  1.00 34.41 ? 704 GLY A CA    1 
ATOM   4939 C  C     . GLY A 1 704 ? 107.094 99.939  86.848  1.00 34.41 ? 704 GLY A C     1 
ATOM   4940 O  O     . GLY A 1 704 ? 106.318 99.637  85.934  1.00 34.41 ? 704 GLY A O     1 
ATOM   4941 N  N     . THR A 1 705 ? 106.728 99.910  88.131  1.00 32.16 ? 705 THR A N     1 
ATOM   4942 C  CA    . THR A 1 705 ? 105.408 99.448  88.545  1.00 32.16 ? 705 THR A CA    1 
ATOM   4943 C  C     . THR A 1 705 ? 104.307 100.446 88.243  1.00 32.16 ? 705 THR A C     1 
ATOM   4944 O  O     . THR A 1 705 ? 103.160 100.210 88.630  1.00 32.16 ? 705 THR A O     1 
ATOM   4945 C  CB    . THR A 1 705 ? 105.397 99.122  90.039  1.00 32.16 ? 705 THR A CB    1 
ATOM   4946 O  OG1   . THR A 1 705 ? 105.747 100.292 90.786  1.00 32.16 ? 705 THR A OG1   1 
ATOM   4947 C  CG2   . THR A 1 705 ? 106.380 98.016  90.352  1.00 32.16 ? 705 THR A CG2   1 
ATOM   4948 N  N     . SER A 1 706 ? 104.614 101.552 87.568  1.00 37.11 ? 706 SER A N     1 
ATOM   4949 C  CA    . SER A 1 706 ? 103.584 102.530 87.248  1.00 37.11 ? 706 SER A CA    1 
ATOM   4950 C  C     . SER A 1 706 ? 103.587 102.907 85.771  1.00 37.11 ? 706 SER A C     1 
ATOM   4951 O  O     . SER A 1 706 ? 103.035 103.952 85.409  1.00 37.11 ? 706 SER A O     1 
ATOM   4952 C  CB    . SER A 1 706 ? 103.749 103.789 88.098  1.00 37.11 ? 706 SER A CB    1 
ATOM   4953 O  OG    . SER A 1 706 ? 102.963 104.848 87.584  1.00 37.11 ? 706 SER A OG    1 
ATOM   4954 N  N     . GLN A 1 707 ? 104.193 102.089 84.912  1.00 40.19 ? 707 GLN A N     1 
ATOM   4955 C  CA    . GLN A 1 707 ? 104.248 102.369 83.482  1.00 40.19 ? 707 GLN A CA    1 
ATOM   4956 C  C     . GLN A 1 707 ? 103.797 101.216 82.600  1.00 40.19 ? 707 GLN A C     1 
ATOM   4957 O  O     . GLN A 1 707 ? 103.407 101.467 81.454  1.00 40.19 ? 707 GLN A O     1 
ATOM   4958 C  CB    . GLN A 1 707 ? 105.671 102.773 83.069  1.00 40.19 ? 707 GLN A CB    1 
ATOM   4959 C  CG    . GLN A 1 707 ? 106.212 103.968 83.829  1.00 40.19 ? 707 GLN A CG    1 
ATOM   4960 C  CD    . GLN A 1 707 ? 107.701 103.879 84.062  1.00 40.19 ? 707 GLN A CD    1 
ATOM   4961 O  OE1   . GLN A 1 707 ? 108.381 103.034 83.483  1.00 40.19 ? 707 GLN A OE1   1 
ATOM   4962 N  NE2   . GLN A 1 707 ? 108.218 104.744 84.926  1.00 40.19 ? 707 GLN A NE2   1 
ATOM   4963 N  N     . ASN A 1 708 ? 103.832 99.976  83.080  1.00 38.50 ? 708 ASN A N     1 
ATOM   4964 C  CA    . ASN A 1 708 ? 103.448 98.834  82.268  1.00 38.50 ? 708 ASN A CA    1 
ATOM   4965 C  C     . ASN A 1 708 ? 101.927 98.712  82.180  1.00 38.50 ? 708 ASN A C     1 
ATOM   4966 O  O     . ASN A 1 708 ? 101.176 99.332  82.935  1.00 38.50 ? 708 ASN A O     1 
ATOM   4967 C  CB    . ASN A 1 708 ? 104.044 97.549  82.839  1.00 38.50 ? 708 ASN A CB    1 
ATOM   4968 C  CG    . ASN A 1 708 ? 105.390 97.216  82.238  1.00 38.50 ? 708 ASN A CG    1 
ATOM   4969 O  OD1   . ASN A 1 708 ? 106.002 98.043  81.567  1.00 38.50 ? 708 ASN A OD1   1 
ATOM   4970 N  ND2   . ASN A 1 708 ? 105.856 95.997  82.470  1.00 38.50 ? 708 ASN A ND2   1 
ATOM   4971 N  N     . ASN A 1 709 ? 101.478 97.897  81.228  1.00 38.69 ? 709 ASN A N     1 
ATOM   4972 C  CA    . ASN A 1 709 ? 100.071 97.559  81.086  1.00 38.69 ? 709 ASN A CA    1 
ATOM   4973 C  C     . ASN A 1 709 ? 99.814  96.241  81.794  1.00 38.69 ? 709 ASN A C     1 
ATOM   4974 O  O     . ASN A 1 709 ? 100.401 95.223  81.398  1.00 38.69 ? 709 ASN A O     1 
ATOM   4975 C  CB    . ASN A 1 709 ? 99.697  97.450  79.614  1.00 38.69 ? 709 ASN A CB    1 
ATOM   4976 C  CG    . ASN A 1 709 ? 98.206  97.303  79.393  1.00 38.69 ? 709 ASN A CG    1 
ATOM   4977 O  OD1   . ASN A 1 709 ? 97.734  97.225  78.261  1.00 38.69 ? 709 ASN A OD1   1 
ATOM   4978 N  ND2   . ASN A 1 709 ? 97.452  97.273  80.483  1.00 38.69 ? 709 ASN A ND2   1 
ATOM   4979 N  N     . PRO A 1 710 ? 98.975  96.199  82.832  1.00 36.30 ? 710 PRO A N     1 
ATOM   4980 C  CA    . PRO A 1 710 ? 98.808  94.945  83.586  1.00 36.30 ? 710 PRO A CA    1 
ATOM   4981 C  C     . PRO A 1 710 ? 98.327  93.776  82.744  1.00 36.30 ? 710 PRO A C     1 
ATOM   4982 O  O     . PRO A 1 710 ? 98.702  92.632  83.022  1.00 36.30 ? 710 PRO A O     1 
ATOM   4983 C  CB    . PRO A 1 710 ? 97.786  95.325  84.665  1.00 36.30 ? 710 PRO A CB    1 
ATOM   4984 C  CG    . PRO A 1 710 ? 97.934  96.789  84.822  1.00 36.30 ? 710 PRO A CG    1 
ATOM   4985 C  CD    . PRO A 1 710 ? 98.248  97.316  83.456  1.00 36.30 ? 710 PRO A CD    1 
ATOM   4986 N  N     . ILE A 1 711 ? 97.516  94.023  81.717  1.00 39.32 ? 711 ILE A N     1 
ATOM   4987 C  CA    . ILE A 1 711 ? 96.965  92.927  80.927  1.00 39.32 ? 711 ILE A CA    1 
ATOM   4988 C  C     . ILE A 1 711 ? 97.952  92.471  79.860  1.00 39.32 ? 711 ILE A C     1 
ATOM   4989 O  O     . ILE A 1 711 ? 98.260  91.280  79.748  1.00 39.32 ? 711 ILE A O     1 
ATOM   4990 C  CB    . ILE A 1 711 ? 95.620  93.345  80.309  1.00 39.32 ? 711 ILE A CB    1 
ATOM   4991 C  CG1   . ILE A 1 711 ? 94.674  93.853  81.395  1.00 39.32 ? 711 ILE A CG1   1 
ATOM   4992 C  CG2   . ILE A 1 711 ? 94.998  92.187  79.556  1.00 39.32 ? 711 ILE A CG2   1 
ATOM   4993 C  CD1   . ILE A 1 711 ? 93.451  94.551  80.859  1.00 39.32 ? 711 ILE A CD1   1 
ATOM   4994 N  N     . SER A 1 712 ? 98.466  93.407  79.061  1.00 41.11 ? 712 SER A N     1 
ATOM   4995 C  CA    . SER A 1 712 ? 99.286  93.068  77.904  1.00 41.11 ? 712 SER A CA    1 
ATOM   4996 C  C     . SER A 1 712 ? 100.780 93.040  78.192  1.00 41.11 ? 712 SER A C     1 
ATOM   4997 O  O     . SER A 1 712 ? 101.516 92.339  77.493  1.00 41.11 ? 712 SER A O     1 
ATOM   4998 C  CB    . SER A 1 712 ? 99.013  94.051  76.760  1.00 41.11 ? 712 SER A CB    1 
ATOM   4999 O  OG    . SER A 1 712 ? 99.256  95.385  77.163  1.00 41.11 ? 712 SER A OG    1 
ATOM   5000 N  N     . GLY A 1 713 ? 101.249 93.776  79.193  1.00 38.12 ? 713 GLY A N     1 
ATOM   5001 C  CA    . GLY A 1 713 ? 102.657 93.787  79.528  1.00 38.12 ? 713 GLY A CA    1 
ATOM   5002 C  C     . GLY A 1 713 ? 103.506 94.761  78.746  1.00 38.12 ? 713 GLY A C     1 
ATOM   5003 O  O     . GLY A 1 713 ? 104.734 94.723  78.874  1.00 38.12 ? 713 GLY A O     1 
ATOM   5004 N  N     . HIS A 1 714 ? 102.898 95.632  77.949  1.00 42.68 ? 714 HIS A N     1 
ATOM   5005 C  CA    . HIS A 1 714 ? 103.608 96.602  77.129  1.00 42.68 ? 714 HIS A CA    1 
ATOM   5006 C  C     . HIS A 1 714 ? 103.863 97.882  77.914  1.00 42.68 ? 714 HIS A C     1 
ATOM   5007 O  O     . HIS A 1 714 ? 103.295 98.109  78.983  1.00 42.68 ? 714 HIS A O     1 
ATOM   5008 C  CB    . HIS A 1 714 ? 102.813 96.917  75.860  1.00 42.68 ? 714 HIS A CB    1 
ATOM   5009 C  CG    . HIS A 1 714 ? 102.855 95.828  74.835  1.00 42.68 ? 714 HIS A CG    1 
ATOM   5010 N  ND1   . HIS A 1 714 ? 101.736 95.404  74.153  1.00 42.68 ? 714 HIS A ND1   1 
ATOM   5011 C  CD2   . HIS A 1 714 ? 103.882 95.075  74.376  1.00 42.68 ? 714 HIS A CD2   1 
ATOM   5012 C  CE1   . HIS A 1 714 ? 102.070 94.437  73.319  1.00 42.68 ? 714 HIS A CE1   1 
ATOM   5013 N  NE2   . HIS A 1 714 ? 103.367 94.218  73.434  1.00 42.68 ? 714 HIS A NE2   1 
ATOM   5014 N  N     . VAL A 1 715 ? 104.736 98.726  77.363  1.00 45.74 ? 715 VAL A N     1 
ATOM   5015 C  CA    . VAL A 1 715 ? 105.073 99.979  78.024  1.00 45.74 ? 715 VAL A CA    1 
ATOM   5016 C  C     . VAL A 1 715 ? 103.978 101.009 77.773  1.00 45.74 ? 715 VAL A C     1 
ATOM   5017 O  O     . VAL A 1 715 ? 103.330 101.026 76.718  1.00 45.74 ? 715 VAL A O     1 
ATOM   5018 C  CB    . VAL A 1 715 ? 106.446 100.496 77.552  1.00 45.74 ? 715 VAL A CB    1 
ATOM   5019 C  CG1   . VAL A 1 715 ? 106.384 100.959 76.106  1.00 45.74 ? 715 VAL A CG1   1 
ATOM   5020 C  CG2   . VAL A 1 715 ? 106.938 101.612 78.457  1.00 45.74 ? 715 VAL A CG2   1 
ATOM   5021 N  N     . GLY A 1 716 ? 103.754 101.869 78.765  1.00 44.00 ? 716 GLY A N     1 
ATOM   5022 C  CA    . GLY A 1 716 ? 102.800 102.943 78.633  1.00 44.00 ? 716 GLY A CA    1 
ATOM   5023 C  C     . GLY A 1 716 ? 103.433 104.265 79.017  1.00 44.00 ? 716 GLY A C     1 
ATOM   5024 O  O     . GLY A 1 716 ? 104.467 104.318 79.680  1.00 44.00 ? 716 GLY A O     1 
ATOM   5025 N  N     . TRP A 1 717 ? 102.791 105.340 78.581  1.00 50.93 ? 717 TRP A N     1 
ATOM   5026 C  CA    . TRP A 1 717 ? 103.262 106.694 78.831  1.00 50.93 ? 717 TRP A CA    1 
ATOM   5027 C  C     . TRP A 1 717 ? 102.304 107.371 79.800  1.00 50.93 ? 717 TRP A C     1 
ATOM   5028 O  O     . TRP A 1 717 ? 101.108 107.484 79.515  1.00 50.93 ? 717 TRP A O     1 
ATOM   5029 C  CB    . TRP A 1 717 ? 103.367 107.477 77.524  1.00 50.93 ? 717 TRP A CB    1 
ATOM   5030 C  CG    . TRP A 1 717 ? 103.691 108.923 77.698  1.00 50.93 ? 717 TRP A CG    1 
ATOM   5031 C  CD1   . TRP A 1 717 ? 104.917 109.465 77.941  1.00 50.93 ? 717 TRP A CD1   1 
ATOM   5032 C  CD2   . TRP A 1 717 ? 102.774 110.019 77.630  1.00 50.93 ? 717 TRP A CD2   1 
ATOM   5033 N  NE1   . TRP A 1 717 ? 104.820 110.832 78.035  1.00 50.93 ? 717 TRP A NE1   1 
ATOM   5034 C  CE2   . TRP A 1 717 ? 103.513 111.196 77.846  1.00 50.93 ? 717 TRP A CE2   1 
ATOM   5035 C  CE3   . TRP A 1 717 ? 101.398 110.119 77.408  1.00 50.93 ? 717 TRP A CE3   1 
ATOM   5036 C  CZ2   . TRP A 1 717 ? 102.923 112.455 77.849  1.00 50.93 ? 717 TRP A CZ2   1 
ATOM   5037 C  CZ3   . TRP A 1 717 ? 100.816 111.368 77.412  1.00 50.93 ? 717 TRP A CZ3   1 
ATOM   5038 C  CH2   . TRP A 1 717 ? 101.576 112.520 77.631  1.00 50.93 ? 717 TRP A CH2   1 
ATOM   5039 N  N     . ARG A 1 718 ? 102.829 107.817 80.938  1.00 54.51 ? 718 ARG A N     1 
ATOM   5040 C  CA    . ARG A 1 718 ? 102.005 108.454 81.956  1.00 54.51 ? 718 ARG A CA    1 
ATOM   5041 C  C     . ARG A 1 718 ? 101.666 109.877 81.540  1.00 54.51 ? 718 ARG A C     1 
ATOM   5042 O  O     . ARG A 1 718 ? 102.551 110.649 81.159  1.00 54.51 ? 718 ARG A O     1 
ATOM   5043 C  CB    . ARG A 1 718 ? 102.723 108.455 83.304  1.00 54.51 ? 718 ARG A CB    1 
ATOM   5044 C  CG    . ARG A 1 718 ? 101.929 109.101 84.424  1.00 54.51 ? 718 ARG A CG    1 
ATOM   5045 C  CD    . ARG A 1 718 ? 102.381 108.595 85.783  1.00 54.51 ? 718 ARG A CD    1 
ATOM   5046 N  NE    . ARG A 1 718 ? 101.585 109.162 86.866  1.00 54.51 ? 718 ARG A NE    1 
ATOM   5047 C  CZ    . ARG A 1 718 ? 101.223 108.499 87.956  1.00 54.51 ? 718 ARG A CZ    1 
ATOM   5048 N  NH1   . ARG A 1 718 ? 101.579 107.240 88.149  1.00 54.51 ? 718 ARG A NH1   1 
ATOM   5049 N  NH2   . ARG A 1 718 ? 100.485 109.115 88.874  1.00 54.51 ? 718 ARG A NH2   1 
ATOM   5050 N  N     . ASN A 1 719 ? 100.385 110.226 81.623  1.00 58.58 ? 719 ASN A N     1 
ATOM   5051 C  CA    . ASN A 1 719 ? 99.921  111.545 81.210  1.00 58.58 ? 719 ASN A CA    1 
ATOM   5052 C  C     . ASN A 1 719 ? 100.486 112.601 82.151  1.00 58.58 ? 719 ASN A C     1 
ATOM   5053 O  O     . ASN A 1 719 ? 100.097 112.671 83.321  1.00 58.58 ? 719 ASN A O     1 
ATOM   5054 C  CB    . ASN A 1 719 ? 98.396  111.581 81.197  1.00 58.58 ? 719 ASN A CB    1 
ATOM   5055 C  CG    . ASN A 1 719 ? 97.848  112.865 80.611  1.00 58.58 ? 719 ASN A CG    1 
ATOM   5056 O  OD1   . ASN A 1 719 ? 98.586  113.666 80.040  1.00 58.58 ? 719 ASN A OD1   1 
ATOM   5057 N  ND2   . ASN A 1 719 ? 96.543  113.067 80.748  1.00 58.58 ? 719 ASN A ND2   1 
ATOM   5058 N  N     . LYS A 1 720 ? 101.409 113.423 81.646  1.00 61.69 ? 720 LYS A N     1 
ATOM   5059 C  CA    . LYS A 1 720 ? 101.998 114.473 82.472  1.00 61.69 ? 720 LYS A CA    1 
ATOM   5060 C  C     . LYS A 1 720 ? 100.957 115.505 82.885  1.00 61.69 ? 720 LYS A C     1 
ATOM   5061 O  O     . LYS A 1 720 ? 100.984 116.003 84.017  1.00 61.69 ? 720 LYS A O     1 
ATOM   5062 C  CB    . LYS A 1 720 ? 103.151 115.144 81.726  1.00 61.69 ? 720 LYS A CB    1 
ATOM   5063 C  CG    . LYS A 1 720 ? 104.317 114.230 81.336  1.00 61.69 ? 720 LYS A CG    1 
ATOM   5064 C  CD    . LYS A 1 720 ? 105.156 113.776 82.534  1.00 61.69 ? 720 LYS A CD    1 
ATOM   5065 C  CE    . LYS A 1 720 ? 104.714 112.432 83.099  1.00 61.69 ? 720 LYS A CE    1 
ATOM   5066 N  NZ    . LYS A 1 720 ? 105.614 111.968 84.192  1.00 61.69 ? 720 LYS A NZ    1 
ATOM   5067 N  N     . GLN A 1 721 ? 100.042 115.849 81.978  1.00 65.05 ? 721 GLN A N     1 
ATOM   5068 C  CA    . GLN A 1 721 ? 99.032  116.854 82.292  1.00 65.05 ? 721 GLN A CA    1 
ATOM   5069 C  C     . GLN A 1 721 ? 98.106  116.379 83.405  1.00 65.05 ? 721 GLN A C     1 
ATOM   5070 O  O     . GLN A 1 721 ? 97.737  117.158 84.291  1.00 65.05 ? 721 GLN A O     1 
ATOM   5071 C  CB    . GLN A 1 721 ? 98.237  117.204 81.034  1.00 65.05 ? 721 GLN A CB    1 
ATOM   5072 C  CG    . GLN A 1 721 ? 97.283  118.379 81.193  1.00 65.05 ? 721 GLN A CG    1 
ATOM   5073 C  CD    . GLN A 1 721 ? 95.899  117.954 81.641  1.00 65.05 ? 721 GLN A CD    1 
ATOM   5074 O  OE1   . GLN A 1 721 ? 95.440  116.858 81.320  1.00 65.05 ? 721 GLN A OE1   1 
ATOM   5075 N  NE2   . GLN A 1 721 ? 95.227  118.822 82.387  1.00 65.05 ? 721 GLN A NE2   1 
ATOM   5076 N  N     . ASN A 1 722 ? 97.721  115.104 83.378  1.00 63.10 ? 722 ASN A N     1 
ATOM   5077 C  CA    . ASN A 1 722 ? 96.835  114.517 84.383  1.00 63.10 ? 722 ASN A CA    1 
ATOM   5078 C  C     . ASN A 1 722 ? 97.531  113.289 84.964  1.00 63.10 ? 722 ASN A C     1 
ATOM   5079 O  O     . ASN A 1 722 ? 97.544  112.225 84.340  1.00 63.10 ? 722 ASN A O     1 
ATOM   5080 C  CB    . ASN A 1 722 ? 95.484  114.155 83.779  1.00 63.10 ? 722 ASN A CB    1 
ATOM   5081 C  CG    . ASN A 1 722 ? 94.410  113.970 84.828  1.00 63.10 ? 722 ASN A CG    1 
ATOM   5082 O  OD1   . ASN A 1 722 ? 94.643  114.185 86.016  1.00 63.10 ? 722 ASN A OD1   1 
ATOM   5083 N  ND2   . ASN A 1 722 ? 93.221  113.572 84.392  1.00 63.10 ? 722 ASN A ND2   1 
ATOM   5084 N  N     . LYS A 1 723 ? 98.100  113.435 86.163  1.00 60.56 ? 723 LYS A N     1 
ATOM   5085 C  CA    . LYS A 1 723 ? 98.892  112.362 86.755  1.00 60.56 ? 723 LYS A CA    1 
ATOM   5086 C  C     . LYS A 1 723 ? 98.072  111.118 87.070  1.00 60.56 ? 723 LYS A C     1 
ATOM   5087 O  O     . LYS A 1 723 ? 98.648  110.033 87.202  1.00 60.56 ? 723 LYS A O     1 
ATOM   5088 C  CB    . LYS A 1 723 ? 99.585  112.848 88.031  1.00 60.56 ? 723 LYS A CB    1 
ATOM   5089 C  CG    . LYS A 1 723 ? 100.858 113.658 87.812  1.00 60.56 ? 723 LYS A CG    1 
ATOM   5090 C  CD    . LYS A 1 723 ? 100.581 115.056 87.290  1.00 60.56 ? 723 LYS A CD    1 
ATOM   5091 C  CE    . LYS A 1 723 ? 101.866 115.860 87.177  1.00 60.56 ? 723 LYS A CE    1 
ATOM   5092 N  NZ    . LYS A 1 723 ? 101.638 117.194 86.558  1.00 60.56 ? 723 LYS A NZ    1 
ATOM   5093 N  N     . SER A 1 724 ? 96.752  111.240 87.193  1.00 58.30 ? 724 SER A N     1 
ATOM   5094 C  CA    . SER A 1 724 ? 95.933  110.105 87.599  1.00 58.30 ? 724 SER A CA    1 
ATOM   5095 C  C     . SER A 1 724 ? 95.566  109.181 86.445  1.00 58.30 ? 724 SER A C     1 
ATOM   5096 O  O     . SER A 1 724 ? 94.904  108.166 86.680  1.00 58.30 ? 724 SER A O     1 
ATOM   5097 C  CB    . SER A 1 724 ? 94.654  110.594 88.281  1.00 58.30 ? 724 SER A CB    1 
ATOM   5098 O  OG    . SER A 1 724 ? 93.690  111.001 87.327  1.00 58.30 ? 724 SER A OG    1 
ATOM   5099 N  N     . GLU A 1 725 ? 95.966  109.499 85.218  1.00 56.22 ? 725 GLU A N     1 
ATOM   5100 C  CA    . GLU A 1 725 ? 95.654  108.682 84.054  1.00 56.22 ? 725 GLU A CA    1 
ATOM   5101 C  C     . GLU A 1 725 ? 96.934  108.254 83.350  1.00 56.22 ? 725 GLU A C     1 
ATOM   5102 O  O     . GLU A 1 725 ? 97.877  109.040 83.223  1.00 56.22 ? 725 GLU A O     1 
ATOM   5103 C  CB    . GLU A 1 725 ? 94.754  109.440 83.078  1.00 56.22 ? 725 GLU A CB    1 
ATOM   5104 C  CG    . GLU A 1 725 ? 93.282  109.123 83.231  1.00 56.22 ? 725 GLU A CG    1 
ATOM   5105 C  CD    . GLU A 1 725 ? 92.397  110.104 82.491  1.00 56.22 ? 725 GLU A CD    1 
ATOM   5106 O  OE1   . GLU A 1 725 ? 92.939  111.026 81.847  1.00 56.22 ? 725 GLU A OE1   1 
ATOM   5107 O  OE2   . GLU A 1 725 ? 91.159  109.953 82.550  1.00 56.22 ? 725 GLU A OE2   1 
ATOM   5108 N  N     . ILE A 1 726 ? 96.957  107.005 82.891  1.00 47.72 ? 726 ILE A N     1 
ATOM   5109 C  CA    . ILE A 1 726 ? 98.079  106.449 82.146  1.00 47.72 ? 726 ILE A CA    1 
ATOM   5110 C  C     . ILE A 1 726 ? 97.545  105.860 80.848  1.00 47.72 ? 726 ILE A C     1 
ATOM   5111 O  O     . ILE A 1 726 ? 96.475  105.241 80.831  1.00 47.72 ? 726 ILE A O     1 
ATOM   5112 C  CB    . ILE A 1 726 ? 98.842  105.392 82.973  1.00 47.72 ? 726 ILE A CB    1 
ATOM   5113 C  CG1   . ILE A 1 726 ? 99.963  104.767 82.150  1.00 47.72 ? 726 ILE A CG1   1 
ATOM   5114 C  CG2   . ILE A 1 726 ? 97.900  104.331 83.490  1.00 47.72 ? 726 ILE A CG2   1 
ATOM   5115 C  CD1   . ILE A 1 726 ? 100.964 104.009 82.979  1.00 47.72 ? 726 ILE A CD1   1 
ATOM   5116 N  N     . TYR A 1 727 ? 98.275  106.072 79.756  1.00 49.62 ? 727 TYR A N     1 
ATOM   5117 C  CA    . TYR A 1 727 ? 97.810  105.737 78.418  1.00 49.62 ? 727 TYR A CA    1 
ATOM   5118 C  C     . TYR A 1 727 ? 98.671  104.638 77.813  1.00 49.62 ? 727 TYR A C     1 
ATOM   5119 O  O     . TYR A 1 727 ? 99.883  104.591 78.039  1.00 49.62 ? 727 TYR A O     1 
ATOM   5120 C  CB    . TYR A 1 727 ? 97.834  106.969 77.518  1.00 49.62 ? 727 TYR A CB    1 
ATOM   5121 C  CG    . TYR A 1 727 ? 96.723  107.953 77.799  1.00 49.62 ? 727 TYR A CG    1 
ATOM   5122 C  CD1   . TYR A 1 727 ? 95.445  107.740 77.311  1.00 49.62 ? 727 TYR A CD1   1 
ATOM   5123 C  CD2   . TYR A 1 727 ? 96.953  109.093 78.555  1.00 49.62 ? 727 TYR A CD2   1 
ATOM   5124 C  CE1   . TYR A 1 727 ? 94.428  108.636 77.558  1.00 49.62 ? 727 TYR A CE1   1 
ATOM   5125 C  CE2   . TYR A 1 727 ? 95.939  109.994 78.812  1.00 49.62 ? 727 TYR A CE2   1 
ATOM   5126 C  CZ    . TYR A 1 727 ? 94.679  109.759 78.311  1.00 49.62 ? 727 TYR A CZ    1 
ATOM   5127 O  OH    . TYR A 1 727 ? 93.662  110.651 78.561  1.00 49.62 ? 727 TYR A OH    1 
ATOM   5128 N  N     . PHE A 1 728 ? 98.037  103.756 77.041  1.00 46.48 ? 728 PHE A N     1 
ATOM   5129 C  CA    . PHE A 1 728 ? 98.697  102.630 76.391  1.00 46.48 ? 728 PHE A CA    1 
ATOM   5130 C  C     . PHE A 1 728 ? 98.280  102.574 74.925  1.00 46.48 ? 728 PHE A C     1 
ATOM   5131 O  O     . PHE A 1 728 ? 97.395  103.308 74.479  1.00 46.48 ? 728 PHE A O     1 
ATOM   5132 C  CB    . PHE A 1 728 ? 98.367  101.308 77.095  1.00 46.48 ? 728 PHE A CB    1 
ATOM   5133 C  CG    . PHE A 1 728 ? 98.637  101.322 78.568  1.00 46.48 ? 728 PHE A CG    1 
ATOM   5134 C  CD1   . PHE A 1 728 ? 99.889  101.011 79.056  1.00 46.48 ? 728 PHE A CD1   1 
ATOM   5135 C  CD2   . PHE A 1 728 ? 97.639  101.653 79.464  1.00 46.48 ? 728 PHE A CD2   1 
ATOM   5136 C  CE1   . PHE A 1 728 ? 100.139 101.024 80.411  1.00 46.48 ? 728 PHE A CE1   1 
ATOM   5137 C  CE2   . PHE A 1 728 ? 97.887  101.671 80.818  1.00 46.48 ? 728 PHE A CE2   1 
ATOM   5138 C  CZ    . PHE A 1 728 ? 99.138  101.353 81.291  1.00 46.48 ? 728 PHE A CZ    1 
ATOM   5139 N  N     . TYR A 1 729 ? 98.923  101.678 74.171  1.00 57.35 ? 729 TYR A N     1 
ATOM   5140 C  CA    . TYR A 1 729 ? 98.623  101.520 72.748  1.00 57.35 ? 729 TYR A CA    1 
ATOM   5141 C  C     . TYR A 1 729 ? 98.806  100.045 72.392  1.00 57.35 ? 729 TYR A C     1 
ATOM   5142 O  O     . TYR A 1 729 ? 99.938  99.591  72.207  1.00 57.35 ? 729 TYR A O     1 
ATOM   5143 C  CB    . TYR A 1 729 ? 99.512  102.411 71.897  1.00 57.35 ? 729 TYR A CB    1 
ATOM   5144 C  CG    . TYR A 1 729 ? 99.225  102.321 70.417  1.00 57.35 ? 729 TYR A CG    1 
ATOM   5145 C  CD1   . TYR A 1 729 ? 98.114  102.938 69.868  1.00 57.35 ? 729 TYR A CD1   1 
ATOM   5146 C  CD2   . TYR A 1 729 ? 100.068 101.619 69.569  1.00 57.35 ? 729 TYR A CD2   1 
ATOM   5147 C  CE1   . TYR A 1 729 ? 97.847  102.858 68.516  1.00 57.35 ? 729 TYR A CE1   1 
ATOM   5148 C  CE2   . TYR A 1 729 ? 99.810  101.533 68.215  1.00 57.35 ? 729 TYR A CE2   1 
ATOM   5149 C  CZ    . TYR A 1 729 ? 98.697  102.155 67.695  1.00 57.35 ? 729 TYR A CZ    1 
ATOM   5150 O  OH    . TYR A 1 729 ? 98.432  102.076 66.347  1.00 57.35 ? 729 TYR A OH    1 
ATOM   5151 N  N     . GLU A 1 730 ? 97.695  99.317  72.294  1.00 57.81 ? 730 GLU A N     1 
ATOM   5152 C  CA    . GLU A 1 730 ? 97.718  97.889  72.006  1.00 57.81 ? 730 GLU A CA    1 
ATOM   5153 C  C     . GLU A 1 730 ? 96.838  97.598  70.800  1.00 57.81 ? 730 GLU A C     1 
ATOM   5154 O  O     . GLU A 1 730 ? 95.647  97.927  70.805  1.00 57.81 ? 730 GLU A O     1 
ATOM   5155 C  CB    . GLU A 1 730 ? 97.233  97.070  73.208  1.00 57.81 ? 730 GLU A CB    1 
ATOM   5156 C  CG    . GLU A 1 730 ? 97.733  97.557  74.557  1.00 57.81 ? 730 GLU A CG    1 
ATOM   5157 C  CD    . GLU A 1 730 ? 99.237  97.695  74.611  1.00 57.81 ? 730 GLU A CD    1 
ATOM   5158 O  OE1   . GLU A 1 730 ? 99.935  96.771  74.147  1.00 57.81 ? 730 GLU A OE1   1 
ATOM   5159 O  OE2   . GLU A 1 730 ? 99.721  98.729  75.118  1.00 57.81 ? 730 GLU A OE2   1 
ATOM   5160 N  N     . ASP A 1 731 ? 97.426  96.972  69.779  1.00 64.54 ? 731 ASP A N     1 
ATOM   5161 C  CA    . ASP A 1 731 ? 96.695  96.485  68.607  1.00 64.54 ? 731 ASP A CA    1 
ATOM   5162 C  C     . ASP A 1 731 ? 95.896  97.601  67.932  1.00 64.54 ? 731 ASP A C     1 
ATOM   5163 O  O     . ASP A 1 731 ? 94.670  97.537  67.819  1.00 64.54 ? 731 ASP A O     1 
ATOM   5164 C  CB    . ASP A 1 731 ? 95.786  95.313  68.982  1.00 64.54 ? 731 ASP A CB    1 
ATOM   5165 C  CG    . ASP A 1 731 ? 96.557  94.026  69.198  1.00 64.54 ? 731 ASP A CG    1 
ATOM   5166 O  OD1   . ASP A 1 731 ? 97.805  94.073  69.204  1.00 64.54 ? 731 ASP A OD1   1 
ATOM   5167 O  OD2   . ASP A 1 731 ? 95.915  92.967  69.363  1.00 64.54 ? 731 ASP A OD2   1 
ATOM   5168 N  N     . LYS A 1 732 ? 96.609  98.637  67.489  1.00 67.90 ? 732 LYS A N     1 
ATOM   5169 C  CA    . LYS A 1 732 ? 96.041  99.748  66.724  1.00 67.90 ? 732 LYS A CA    1 
ATOM   5170 C  C     . LYS A 1 732 ? 94.975  100.517 67.499  1.00 67.90 ? 732 LYS A C     1 
ATOM   5171 O  O     . LYS A 1 732 ? 94.197  101.270 66.905  1.00 67.90 ? 732 LYS A O     1 
ATOM   5172 C  CB    . LYS A 1 732 ? 95.469  99.265  65.385  1.00 67.90 ? 732 LYS A CB    1 
ATOM   5173 C  CG    . LYS A 1 732 ? 96.495  98.631  64.462  1.00 67.90 ? 732 LYS A CG    1 
ATOM   5174 C  CD    . LYS A 1 732 ? 97.519  99.651  63.997  1.00 67.90 ? 732 LYS A CD    1 
ATOM   5175 C  CE    . LYS A 1 732 ? 98.444  99.062  62.946  1.00 67.90 ? 732 LYS A CE    1 
ATOM   5176 N  NZ    . LYS A 1 732 ? 99.346  98.029  63.525  1.00 67.90 ? 732 LYS A NZ    1 
ATOM   5177 N  N     . GLU A 1 733 ? 94.919  100.348 68.817  1.00 64.49 ? 733 GLU A N     1 
ATOM   5178 C  CA    . GLU A 1 733 ? 93.966  101.065 69.650  1.00 64.49 ? 733 GLU A CA    1 
ATOM   5179 C  C     . GLU A 1 733 ? 94.686  101.636 70.861  1.00 64.49 ? 733 GLU A C     1 
ATOM   5180 O  O     . GLU A 1 733 ? 95.623  101.025 71.382  1.00 64.49 ? 733 GLU A O     1 
ATOM   5181 C  CB    . GLU A 1 733 ? 92.818  100.157 70.105  1.00 64.49 ? 733 GLU A CB    1 
ATOM   5182 C  CG    . GLU A 1 733 ? 91.568  100.911 70.520  1.00 64.49 ? 733 GLU A CG    1 
ATOM   5183 C  CD    . GLU A 1 733 ? 90.423  99.987  70.877  1.00 64.49 ? 733 GLU A CD    1 
ATOM   5184 O  OE1   . GLU A 1 733 ? 90.658  98.766  70.993  1.00 64.49 ? 733 GLU A OE1   1 
ATOM   5185 O  OE2   . GLU A 1 733 ? 89.288  100.481 71.042  1.00 64.49 ? 733 GLU A OE2   1 
ATOM   5186 N  N     . LEU A 1 734 ? 94.241  102.806 71.305  1.00 59.39 ? 734 LEU A N     1 
ATOM   5187 C  CA    . LEU A 1 734 ? 94.820  103.473 72.461  1.00 59.39 ? 734 LEU A CA    1 
ATOM   5188 C  C     . LEU A 1 734 ? 93.904  103.286 73.663  1.00 59.39 ? 734 LEU A C     1 
ATOM   5189 O  O     . LEU A 1 734 ? 92.692  103.503 73.574  1.00 59.39 ? 734 LEU A O     1 
ATOM   5190 C  CB    . LEU A 1 734 ? 95.041  104.961 72.166  1.00 59.39 ? 734 LEU A CB    1 
ATOM   5191 C  CG    . LEU A 1 734 ? 95.801  105.834 73.169  1.00 59.39 ? 734 LEU A CG    1 
ATOM   5192 C  CD1   . LEU A 1 734 ? 96.459  106.993 72.457  1.00 59.39 ? 734 LEU A CD1   1 
ATOM   5193 C  CD2   . LEU A 1 734 ? 94.883  106.366 74.235  1.00 59.39 ? 734 LEU A CD2   1 
ATOM   5194 N  N     . LEU A 1 735 ? 94.488  102.880 74.786  1.00 53.29 ? 735 LEU A N     1 
ATOM   5195 C  CA    . LEU A 1 735 ? 93.743  102.600 76.003  1.00 53.29 ? 735 LEU A CA    1 
ATOM   5196 C  C     . LEU A 1 735 ? 94.144  103.572 77.104  1.00 53.29 ? 735 LEU A C     1 
ATOM   5197 O  O     . LEU A 1 735 ? 95.243  104.132 77.100  1.00 53.29 ? 735 LEU A O     1 
ATOM   5198 C  CB    . LEU A 1 735 ? 93.970  101.159 76.478  1.00 53.29 ? 735 LEU A CB    1 
ATOM   5199 C  CG    . LEU A 1 735 ? 94.025  100.070 75.406  1.00 53.29 ? 735 LEU A CG    1 
ATOM   5200 C  CD1   . LEU A 1 735 ? 94.464  98.752  76.014  1.00 53.29 ? 735 LEU A CD1   1 
ATOM   5201 C  CD2   . LEU A 1 735 ? 92.675  99.922  74.731  1.00 53.29 ? 735 LEU A CD2   1 
ATOM   5202 N  N     . VAL A 1 736 ? 93.229  103.772 78.049  1.00 51.36 ? 736 VAL A N     1 
ATOM   5203 C  CA    . VAL A 1 736 ? 93.462  104.609 79.219  1.00 51.36 ? 736 VAL A CA    1 
ATOM   5204 C  C     . VAL A 1 736 ? 93.063  103.830 80.463  1.00 51.36 ? 736 VAL A C     1 
ATOM   5205 O  O     . VAL A 1 736 ? 92.081  103.080 80.451  1.00 51.36 ? 736 VAL A O     1 
ATOM   5206 C  CB    . VAL A 1 736 ? 92.701  105.947 79.129  1.00 51.36 ? 736 VAL A CB    1 
ATOM   5207 C  CG1   . VAL A 1 736 ? 91.205  105.717 79.141  1.00 51.36 ? 736 VAL A CG1   1 
ATOM   5208 C  CG2   . VAL A 1 736 ? 93.110  106.858 80.272  1.00 51.36 ? 736 VAL A CG2   1 
ATOM   5209 N  N     . MET A 1 737 ? 93.844  103.986 81.529  1.00 47.00 ? 737 MET A N     1 
ATOM   5210 C  CA    . MET A 1 737 ? 93.698  103.181 82.732  1.00 47.00 ? 737 MET A CA    1 
ATOM   5211 C  C     . MET A 1 737 ? 94.015  104.050 83.942  1.00 47.00 ? 737 MET A C     1 
ATOM   5212 O  O     . MET A 1 737 ? 94.703  105.067 83.834  1.00 47.00 ? 737 MET A O     1 
ATOM   5213 C  CB    . MET A 1 737 ? 94.613  101.949 82.664  1.00 47.00 ? 737 MET A CB    1 
ATOM   5214 C  CG    . MET A 1 737 ? 94.205  100.968 81.569  1.00 47.00 ? 737 MET A CG    1 
ATOM   5215 S  SD    . MET A 1 737 ? 95.271  99.538  81.345  1.00 47.00 ? 737 MET A SD    1 
ATOM   5216 C  CE    . MET A 1 737 ? 94.928  98.605  82.816  1.00 47.00 ? 737 MET A CE    1 
ATOM   5217 N  N     . ASP A 1 738 ? 93.500  103.646 85.100  1.00 40.55 ? 738 ASP A N     1 
ATOM   5218 C  CA    . ASP A 1 738 ? 93.656  104.438 86.314  1.00 40.55 ? 738 ASP A CA    1 
ATOM   5219 C  C     . ASP A 1 738 ? 95.035  104.194 86.913  1.00 40.55 ? 738 ASP A C     1 
ATOM   5220 O  O     . ASP A 1 738 ? 95.427  103.047 87.141  1.00 40.55 ? 738 ASP A O     1 
ATOM   5221 C  CB    . ASP A 1 738 ? 92.560  104.087 87.320  1.00 40.55 ? 738 ASP A CB    1 
ATOM   5222 C  CG    . ASP A 1 738 ? 92.458  105.090 88.456  1.00 40.55 ? 738 ASP A CG    1 
ATOM   5223 O  OD1   . ASP A 1 738 ? 93.499  105.605 88.912  1.00 40.55 ? 738 ASP A OD1   1 
ATOM   5224 O  OD2   . ASP A 1 738 ? 91.324  105.361 88.903  1.00 40.55 ? 738 ASP A OD2   1 
ATOM   5225 N  N     . ALA A 1 739 ? 95.762  105.281 87.183  1.00 40.37 ? 739 ALA A N     1 
ATOM   5226 C  CA    . ALA A 1 739 ? 97.166  105.165 87.568  1.00 40.37 ? 739 ALA A CA    1 
ATOM   5227 C  C     . ALA A 1 739 ? 97.336  104.412 88.881  1.00 40.37 ? 739 ALA A C     1 
ATOM   5228 O  O     . ALA A 1 739 ? 98.228  103.563 89.005  1.00 40.37 ? 739 ALA A O     1 
ATOM   5229 C  CB    . ALA A 1 739 ? 97.795  106.553 87.664  1.00 40.37 ? 739 ALA A CB    1 
ATOM   5230 N  N     . ASP A 1 740 ? 96.499  104.712 89.877  1.00 37.42 ? 740 ASP A N     1 
ATOM   5231 C  CA    . ASP A 1 740 ? 96.651  104.082 91.186  1.00 37.42 ? 740 ASP A CA    1 
ATOM   5232 C  C     . ASP A 1 740 ? 96.324  102.594 91.130  1.00 37.42 ? 740 ASP A C     1 
ATOM   5233 O  O     . ASP A 1 740 ? 97.035  101.770 91.719  1.00 37.42 ? 740 ASP A O     1 
ATOM   5234 C  CB    . ASP A 1 740 ? 95.768  104.793 92.207  1.00 37.42 ? 740 ASP A CB    1 
ATOM   5235 C  CG    . ASP A 1 740 ? 96.106  106.264 92.338  1.00 37.42 ? 740 ASP A CG    1 
ATOM   5236 O  OD1   . ASP A 1 740 ? 95.622  107.061 91.508  1.00 37.42 ? 740 ASP A OD1   1 
ATOM   5237 O  OD2   . ASP A 1 740 ? 96.859  106.624 93.266  1.00 37.42 ? 740 ASP A OD2   1 
ATOM   5238 N  N     . GLU A 1 741 ? 95.249  102.232 90.428  1.00 35.84 ? 741 GLU A N     1 
ATOM   5239 C  CA    . GLU A 1 741 ? 94.914  100.825 90.250  1.00 35.84 ? 741 GLU A CA    1 
ATOM   5240 C  C     . GLU A 1 741 ? 95.965  100.090 89.431  1.00 35.84 ? 741 GLU A C     1 
ATOM   5241 O  O     . GLU A 1 741 ? 96.273  98.932  89.729  1.00 35.84 ? 741 GLU A O     1 
ATOM   5242 C  CB    . GLU A 1 741 ? 93.541  100.689 89.596  1.00 35.84 ? 741 GLU A CB    1 
ATOM   5243 C  CG    . GLU A 1 741 ? 92.428  101.341 90.392  1.00 35.84 ? 741 GLU A CG    1 
ATOM   5244 C  CD    . GLU A 1 741 ? 91.055  100.983 89.873  1.00 35.84 ? 741 GLU A CD    1 
ATOM   5245 O  OE1   . GLU A 1 741 ? 90.971  100.240 88.873  1.00 35.84 ? 741 GLU A OE1   1 
ATOM   5246 O  OE2   . GLU A 1 741 ? 90.058  101.445 90.466  1.00 35.84 ? 741 GLU A OE2   1 
ATOM   5247 N  N     . VAL A 1 742 ? 96.521  100.740 88.406  1.00 32.96 ? 742 VAL A N     1 
ATOM   5248 C  CA    . VAL A 1 742 ? 97.616  100.138 87.649  1.00 32.96 ? 742 VAL A CA    1 
ATOM   5249 C  C     . VAL A 1 742 ? 98.806  99.868  88.558  1.00 32.96 ? 742 VAL A C     1 
ATOM   5250 O  O     . VAL A 1 742 ? 99.417  98.795  88.500  1.00 32.96 ? 742 VAL A O     1 
ATOM   5251 C  CB    . VAL A 1 742 ? 98.000  101.033 86.457  1.00 32.96 ? 742 VAL A CB    1 
ATOM   5252 C  CG1   . VAL A 1 742 ? 99.350  100.630 85.904  1.00 32.96 ? 742 VAL A CG1   1 
ATOM   5253 C  CG2   . VAL A 1 742 ? 96.953  100.930 85.369  1.00 32.96 ? 742 VAL A CG2   1 
ATOM   5254 N  N     . GLY A 1 743 ? 99.149  100.829 89.415  1.00 29.09 ? 743 GLY A N     1 
ATOM   5255 C  CA    . GLY A 1 743 ? 100.252 100.618 90.339  1.00 29.09 ? 743 GLY A CA    1 
ATOM   5256 C  C     . GLY A 1 743 ? 99.996  99.486  91.316  1.00 29.09 ? 743 GLY A C     1 
ATOM   5257 O  O     . GLY A 1 743 ? 100.885 98.674  91.585  1.00 29.09 ? 743 GLY A O     1 
ATOM   5258 N  N     . ALA A 1 744 ? 98.781  99.419  91.865  1.00 26.70 ? 744 ALA A N     1 
ATOM   5259 C  CA    . ALA A 1 744 ? 98.450  98.344  92.799  1.00 26.70 ? 744 ALA A CA    1 
ATOM   5260 C  C     . ALA A 1 744 ? 98.502  96.980  92.120  1.00 26.70 ? 744 ALA A C     1 
ATOM   5261 O  O     . ALA A 1 744 ? 99.038  96.015  92.682  1.00 26.70 ? 744 ALA A O     1 
ATOM   5262 C  CB    . ALA A 1 744 ? 97.073  98.586  93.410  1.00 26.70 ? 744 ALA A CB    1 
ATOM   5263 N  N     . MET A 1 745 ? 97.956  96.881  90.905  1.00 29.28 ? 745 MET A N     1 
ATOM   5264 C  CA    . MET A 1 745 ? 97.991  95.618  90.179  1.00 29.28 ? 745 MET A CA    1 
ATOM   5265 C  C     . MET A 1 745 ? 99.416  95.223  89.819  1.00 29.28 ? 745 MET A C     1 
ATOM   5266 O  O     . MET A 1 745 ? 99.761  94.039  89.856  1.00 29.28 ? 745 MET A O     1 
ATOM   5267 C  CB    . MET A 1 745 ? 97.126  95.703  88.924  1.00 29.28 ? 745 MET A CB    1 
ATOM   5268 C  CG    . MET A 1 745 ? 95.635  95.754  89.196  1.00 29.28 ? 745 MET A CG    1 
ATOM   5269 S  SD    . MET A 1 745 ? 94.926  94.183  89.726  1.00 29.28 ? 745 MET A SD    1 
ATOM   5270 C  CE    . MET A 1 745 ? 95.876  93.013  88.768  1.00 29.28 ? 745 MET A CE    1 
ATOM   5271 N  N     . ASN A 1 746 ? 100.261 96.193  89.464  1.00 28.72 ? 746 ASN A N     1 
ATOM   5272 C  CA    . ASN A 1 746 ? 101.650 95.870  89.158  1.00 28.72 ? 746 ASN A CA    1 
ATOM   5273 C  C     . ASN A 1 746 ? 102.411 95.432  90.400  1.00 28.72 ? 746 ASN A C     1 
ATOM   5274 O  O     . ASN A 1 746 ? 103.263 94.544  90.314  1.00 28.72 ? 746 ASN A O     1 
ATOM   5275 C  CB    . ASN A 1 746 ? 102.340 97.063  88.499  1.00 28.72 ? 746 ASN A CB    1 
ATOM   5276 C  CG    . ASN A 1 746 ? 102.123 97.105  86.999  1.00 28.72 ? 746 ASN A CG    1 
ATOM   5277 O  OD1   . ASN A 1 746 ? 102.337 96.116  86.304  1.00 28.72 ? 746 ASN A OD1   1 
ATOM   5278 N  ND2   . ASN A 1 746 ? 101.698 98.255  86.493  1.00 28.72 ? 746 ASN A ND2   1 
ATOM   5279 N  N     . ILE A 1 747 ? 102.121 96.031  91.557  1.00 26.31 ? 747 ILE A N     1 
ATOM   5280 C  CA    . ILE A 1 747 ? 102.734 95.564  92.799  1.00 26.31 ? 747 ILE A CA    1 
ATOM   5281 C  C     . ILE A 1 747 ? 102.303 94.134  93.098  1.00 26.31 ? 747 ILE A C     1 
ATOM   5282 O  O     . ILE A 1 747 ? 103.120 93.290  93.485  1.00 26.31 ? 747 ILE A O     1 
ATOM   5283 C  CB    . ILE A 1 747 ? 102.395 96.509  93.966  1.00 26.31 ? 747 ILE A CB    1 
ATOM   5284 C  CG1   . ILE A 1 747 ? 103.035 97.879  93.756  1.00 26.31 ? 747 ILE A CG1   1 
ATOM   5285 C  CG2   . ILE A 1 747 ? 102.871 95.914  95.277  1.00 26.31 ? 747 ILE A CG2   1 
ATOM   5286 C  CD1   . ILE A 1 747 ? 102.376 98.981  94.535  1.00 26.31 ? 747 ILE A CD1   1 
ATOM   5287 N  N     . LEU A 1 748 ? 101.014 93.837  92.915  1.00 26.24 ? 748 LEU A N     1 
ATOM   5288 C  CA    . LEU A 1 748 ? 100.527 92.475  93.122  1.00 26.24 ? 748 LEU A CA    1 
ATOM   5289 C  C     . LEU A 1 748 ? 101.196 91.497  92.162  1.00 26.24 ? 748 LEU A C     1 
ATOM   5290 O  O     . LEU A 1 748 ? 101.590 90.395  92.555  1.00 26.24 ? 748 LEU A O     1 
ATOM   5291 C  CB    . LEU A 1 748 ? 99.007  92.438  92.961  1.00 26.24 ? 748 LEU A CB    1 
ATOM   5292 C  CG    . LEU A 1 748 ? 98.278  91.132  93.281  1.00 26.24 ? 748 LEU A CG    1 
ATOM   5293 C  CD1   . LEU A 1 748 ? 98.335  90.825  94.761  1.00 26.24 ? 748 LEU A CD1   1 
ATOM   5294 C  CD2   . LEU A 1 748 ? 96.842  91.216  92.816  1.00 26.24 ? 748 LEU A CD2   1 
ATOM   5295 N  N     . CYS A 1 749 ? 101.333 91.889  90.894  1.00 27.01 ? 749 CYS A N     1 
ATOM   5296 C  CA    . CYS A 1 749 ? 101.925 91.008  89.892  1.00 27.01 ? 749 CYS A CA    1 
ATOM   5297 C  C     . CYS A 1 749 ? 103.403 90.763  90.164  1.00 27.01 ? 749 CYS A C     1 
ATOM   5298 O  O     . CYS A 1 749 ? 103.901 89.650  89.966  1.00 27.01 ? 749 CYS A O     1 
ATOM   5299 C  CB    . CYS A 1 749 ? 101.725 91.600  88.499  1.00 27.01 ? 749 CYS A CB    1 
ATOM   5300 S  SG    . CYS A 1 749 ? 100.062 91.389  87.829  1.00 27.01 ? 749 CYS A SG    1 
ATOM   5301 N  N     . ARG A 1 750 ? 104.129 91.794  90.602  1.00 29.55 ? 750 ARG A N     1 
ATOM   5302 C  CA    . ARG A 1 750 ? 105.530 91.606  90.959  1.00 29.55 ? 750 ARG A CA    1 
ATOM   5303 C  C     . ARG A 1 750 ? 105.682 90.774  92.223  1.00 29.55 ? 750 ARG A C     1 
ATOM   5304 O  O     . ARG A 1 750 ? 106.642 90.007  92.342  1.00 29.55 ? 750 ARG A O     1 
ATOM   5305 C  CB    . ARG A 1 750 ? 106.222 92.955  91.128  1.00 29.55 ? 750 ARG A CB    1 
ATOM   5306 C  CG    . ARG A 1 750 ? 106.486 93.680  89.824  1.00 29.55 ? 750 ARG A CG    1 
ATOM   5307 C  CD    . ARG A 1 750 ? 107.609 94.689  89.970  1.00 29.55 ? 750 ARG A CD    1 
ATOM   5308 N  NE    . ARG A 1 750 ? 108.921 94.112  89.703  1.00 29.55 ? 750 ARG A NE    1 
ATOM   5309 C  CZ    . ARG A 1 750 ? 109.949 94.791  89.213  1.00 29.55 ? 750 ARG A CZ    1 
ATOM   5310 N  NH1   . ARG A 1 750 ? 109.851 96.075  88.918  1.00 29.55 ? 750 ARG A NH1   1 
ATOM   5311 N  NH2   . ARG A 1 750 ? 111.105 94.166  89.017  1.00 29.55 ? 750 ARG A NH2   1 
ATOM   5312 N  N     . GLY A 1 751 ? 104.764 90.920  93.180  1.00 27.13 ? 751 GLY A N     1 
ATOM   5313 C  CA    . GLY A 1 751 ? 104.818 90.086  94.370  1.00 27.13 ? 751 GLY A CA    1 
ATOM   5314 C  C     . GLY A 1 751 ? 104.547 88.626  94.066  1.00 27.13 ? 751 GLY A C     1 
ATOM   5315 O  O     . GLY A 1 751 ? 105.229 87.735  94.575  1.00 27.13 ? 751 GLY A O     1 
ATOM   5316 N  N     . LEU A 1 752 ? 103.539 88.363  93.233  1.00 27.13 ? 752 LEU A N     1 
ATOM   5317 C  CA    . LEU A 1 752 ? 103.238 87.006  92.795  1.00 27.13 ? 752 LEU A CA    1 
ATOM   5318 C  C     . LEU A 1 752 ? 104.312 86.431  91.887  1.00 27.13 ? 752 LEU A C     1 
ATOM   5319 O  O     . LEU A 1 752 ? 104.324 85.216  91.666  1.00 27.13 ? 752 LEU A O     1 
ATOM   5320 C  CB    . LEU A 1 752 ? 101.885 86.974  92.079  1.00 27.13 ? 752 LEU A CB    1 
ATOM   5321 C  CG    . LEU A 1 752 ? 100.621 86.675  92.890  1.00 27.13 ? 752 LEU A CG    1 
ATOM   5322 C  CD1   . LEU A 1 752 ? 100.237 87.831  93.777  1.00 27.13 ? 752 LEU A CD1   1 
ATOM   5323 C  CD2   . LEU A 1 752 ? 99.479  86.349  91.954  1.00 27.13 ? 752 LEU A CD2   1 
ATOM   5324 N  N     . ASN A 1 753 ? 105.201 87.265  91.353  1.00 30.83 ? 753 ASN A N     1 
ATOM   5325 C  CA    . ASN A 1 753 ? 106.307 86.817  90.518  1.00 30.83 ? 753 ASN A CA    1 
ATOM   5326 C  C     . ASN A 1 753 ? 107.652 86.938  91.219  1.00 30.83 ? 753 ASN A C     1 
ATOM   5327 O  O     . ASN A 1 753 ? 108.687 86.691  90.594  1.00 30.83 ? 753 ASN A O     1 
ATOM   5328 C  CB    . ASN A 1 753 ? 106.333 87.605  89.208  1.00 30.83 ? 753 ASN A CB    1 
ATOM   5329 C  CG    . ASN A 1 753 ? 106.781 86.765  88.039  1.00 30.83 ? 753 ASN A CG    1 
ATOM   5330 O  OD1   . ASN A 1 753 ? 107.741 86.009  88.136  1.00 30.83 ? 753 ASN A OD1   1 
ATOM   5331 N  ND2   . ASN A 1 753 ? 106.073 86.880  86.926  1.00 30.83 ? 753 ASN A ND2   1 
ATOM   5332 N  N     . HIS A 1 754 ? 107.662 87.328  92.493  1.00 30.06 ? 754 HIS A N     1 
ATOM   5333 C  CA    . HIS A 1 754 ? 108.877 87.468  93.292  1.00 30.06 ? 754 HIS A CA    1 
ATOM   5334 C  C     . HIS A 1 754 ? 109.827 88.514  92.719  1.00 30.06 ? 754 HIS A C     1 
ATOM   5335 O  O     . HIS A 1 754 ? 111.010 88.536  93.069  1.00 30.06 ? 754 HIS A O     1 
ATOM   5336 C  CB    . HIS A 1 754 ? 109.603 86.127  93.443  1.00 30.06 ? 754 HIS A CB    1 
ATOM   5337 C  CG    . HIS A 1 754 ? 108.759 85.041  94.034  1.00 30.06 ? 754 HIS A CG    1 
ATOM   5338 N  ND1   . HIS A 1 754 ? 109.293 84.004  94.768  1.00 30.06 ? 754 HIS A ND1   1 
ATOM   5339 C  CD2   . HIS A 1 754 ? 107.424 84.826  93.998  1.00 30.06 ? 754 HIS A CD2   1 
ATOM   5340 C  CE1   . HIS A 1 754 ? 108.323 83.196  95.152  1.00 30.06 ? 754 HIS A CE1   1 
ATOM   5341 N  NE2   . HIS A 1 754 ? 107.178 83.675  94.702  1.00 30.06 ? 754 HIS A NE2   1 
ATOM   5342 N  N     . SER A 1 755 ? 109.317 89.380  91.841  1.00 32.59 ? 755 SER A N     1 
ATOM   5343 C  CA    . SER A 1 755 ? 110.094 90.445  91.204  1.00 32.59 ? 755 SER A CA    1 
ATOM   5344 C  C     . SER A 1 755 ? 111.295 89.894  90.435  1.00 32.59 ? 755 SER A C     1 
ATOM   5345 O  O     . SER A 1 755 ? 112.361 90.507  90.386  1.00 32.59 ? 755 SER A O     1 
ATOM   5346 C  CB    . SER A 1 755 ? 110.542 91.485  92.233  1.00 32.59 ? 755 SER A CB    1 
ATOM   5347 O  OG    . SER A 1 755 ? 109.433 92.143  92.810  1.00 32.59 ? 755 SER A OG    1 
ATOM   5348 N  N     . VAL A 1 756 ? 111.113 88.734  89.805  1.00 34.83 ? 756 VAL A N     1 
ATOM   5349 C  CA    . VAL A 1 756 ? 112.215 88.100  89.089  1.00 34.83 ? 756 VAL A CA    1 
ATOM   5350 C  C     . VAL A 1 756 ? 112.231 88.565  87.640  1.00 34.83 ? 756 VAL A C     1 
ATOM   5351 O  O     . VAL A 1 756 ? 113.250 88.440  86.953  1.00 34.83 ? 756 VAL A O     1 
ATOM   5352 C  CB    . VAL A 1 756 ? 112.145 86.565  89.173  1.00 34.83 ? 756 VAL A CB    1 
ATOM   5353 C  CG1   . VAL A 1 756 ? 111.976 86.120  90.611  1.00 34.83 ? 756 VAL A CG1   1 
ATOM   5354 C  CG2   . VAL A 1 756 ? 111.027 86.043  88.314  1.00 34.83 ? 756 VAL A CG2   1 
ATOM   5355 N  N     . CYS A 1 757 ? 111.118 89.096  87.163  1.00 36.71 ? 757 CYS A N     1 
ATOM   5356 C  CA    . CYS A 1 757 ? 111.100 89.675  85.828  1.00 36.71 ? 757 CYS A CA    1 
ATOM   5357 C  C     . CYS A 1 757 ? 111.511 91.140  85.908  1.00 36.71 ? 757 CYS A C     1 
ATOM   5358 O  O     . CYS A 1 757 ? 110.761 91.960  86.450  1.00 36.71 ? 757 CYS A O     1 
ATOM   5359 C  CB    . CYS A 1 757 ? 109.714 89.545  85.202  1.00 36.71 ? 757 CYS A CB    1 
ATOM   5360 S  SG    . CYS A 1 757 ? 109.560 90.269  83.559  1.00 36.71 ? 757 CYS A SG    1 
ATOM   5361 N  N     . PRO A 1 758 ? 112.670 91.512  85.377  1.00 38.95 ? 758 PRO A N     1 
ATOM   5362 C  CA    . PRO A 1 758 ? 113.136 92.894  85.498  1.00 38.95 ? 758 PRO A CA    1 
ATOM   5363 C  C     . PRO A 1 758 ? 112.420 93.818  84.525  1.00 38.95 ? 758 PRO A C     1 
ATOM   5364 O  O     . PRO A 1 758 ? 111.625 93.405  83.683  1.00 38.95 ? 758 PRO A O     1 
ATOM   5365 C  CB    . PRO A 1 758 ? 114.624 92.791  85.161  1.00 38.95 ? 758 PRO A CB    1 
ATOM   5366 C  CG    . PRO A 1 758 ? 114.698 91.644  84.228  1.00 38.95 ? 758 PRO A CG    1 
ATOM   5367 C  CD    . PRO A 1 758 ? 113.658 90.661  84.694  1.00 38.95 ? 758 PRO A CD    1 
ATOM   5368 N  N     . TYR A 1 759 ? 112.736 95.100  84.661  1.00 41.07 ? 759 TYR A N     1 
ATOM   5369 C  CA    . TYR A 1 759 ? 112.182 96.146  83.816  1.00 41.07 ? 759 TYR A CA    1 
ATOM   5370 C  C     . TYR A 1 759 ? 113.300 96.786  83.003  1.00 41.07 ? 759 TYR A C     1 
ATOM   5371 O  O     . TYR A 1 759 ? 113.089 97.215  81.864  1.00 41.07 ? 759 TYR A O     1 
ATOM   5372 C  CB    . TYR A 1 759 ? 111.461 97.178  84.685  1.00 41.07 ? 759 TYR A CB    1 
ATOM   5373 C  CG    . TYR A 1 759 ? 110.841 98.324  83.933  1.00 41.07 ? 759 TYR A CG    1 
ATOM   5374 C  CD1   . TYR A 1 759 ? 109.705 98.142  83.166  1.00 41.07 ? 759 TYR A CD1   1 
ATOM   5375 C  CD2   . TYR A 1 759 ? 111.383 99.595  84.009  1.00 41.07 ? 759 TYR A CD2   1 
ATOM   5376 C  CE1   . TYR A 1 759 ? 109.135 99.191  82.487  1.00 41.07 ? 759 TYR A CE1   1 
ATOM   5377 C  CE2   . TYR A 1 759 ? 110.821 100.649 83.336  1.00 41.07 ? 759 TYR A CE2   1 
ATOM   5378 C  CZ    . TYR A 1 759 ? 109.697 100.443 82.577  1.00 41.07 ? 759 TYR A CZ    1 
ATOM   5379 O  OH    . TYR A 1 759 ? 109.131 101.497 81.902  1.00 41.07 ? 759 TYR A OH    1 
ATOM   5380 N  N     . SER A 1 760 ? 114.497 96.837  83.582  1.00 45.71 ? 760 SER A N     1 
ATOM   5381 C  CA    . SER A 1 760 ? 115.658 97.441  82.949  1.00 45.71 ? 760 SER A CA    1 
ATOM   5382 C  C     . SER A 1 760 ? 116.907 96.828  83.558  1.00 45.71 ? 760 SER A C     1 
ATOM   5383 O  O     . SER A 1 760 ? 116.936 96.540  84.756  1.00 45.71 ? 760 SER A O     1 
ATOM   5384 C  CB    . SER A 1 760 ? 115.677 98.959  83.144  1.00 45.71 ? 760 SER A CB    1 
ATOM   5385 O  OG    . SER A 1 760 ? 114.442 99.543  82.777  1.00 45.71 ? 760 SER A OG    1 
ATOM   5386 N  N     . PHE A 1 761 ? 117.933 96.633  82.734  1.00 55.03 ? 761 PHE A N     1 
ATOM   5387 C  CA    . PHE A 1 761 ? 119.205 96.142  83.238  1.00 55.03 ? 761 PHE A CA    1 
ATOM   5388 C  C     . PHE A 1 761 ? 120.325 96.578  82.307  1.00 55.03 ? 761 PHE A C     1 
ATOM   5389 O  O     . PHE A 1 761 ? 120.123 96.779  81.107  1.00 55.03 ? 761 PHE A O     1 
ATOM   5390 C  CB    . PHE A 1 761 ? 119.205 94.616  83.403  1.00 55.03 ? 761 PHE A CB    1 
ATOM   5391 C  CG    . PHE A 1 761 ? 118.948 93.857  82.130  1.00 55.03 ? 761 PHE A CG    1 
ATOM   5392 C  CD1   . PHE A 1 761 ? 117.673 93.768  81.599  1.00 55.03 ? 761 PHE A CD1   1 
ATOM   5393 C  CD2   . PHE A 1 761 ? 119.983 93.210  81.478  1.00 55.03 ? 761 PHE A CD2   1 
ATOM   5394 C  CE1   . PHE A 1 761 ? 117.439 93.062  80.438  1.00 55.03 ? 761 PHE A CE1   1 
ATOM   5395 C  CE2   . PHE A 1 761 ? 119.754 92.503  80.316  1.00 55.03 ? 761 PHE A CE2   1 
ATOM   5396 C  CZ    . PHE A 1 761 ? 118.482 92.428  79.797  1.00 55.03 ? 761 PHE A CZ    1 
ATOM   5397 N  N     . VAL A 1 762 ? 121.517 96.725  82.885  1.00 59.56 ? 762 VAL A N     1 
ATOM   5398 C  CA    . VAL A 1 762 ? 122.724 97.033  82.128  1.00 59.56 ? 762 VAL A CA    1 
ATOM   5399 C  C     . VAL A 1 762 ? 123.214 95.763  81.450  1.00 59.56 ? 762 VAL A C     1 
ATOM   5400 O  O     . VAL A 1 762 ? 122.832 94.653  81.837  1.00 59.56 ? 762 VAL A O     1 
ATOM   5401 C  CB    . VAL A 1 762 ? 123.819 97.627  83.032  1.00 59.56 ? 762 VAL A CB    1 
ATOM   5402 C  CG1   . VAL A 1 762 ? 123.426 99.011  83.506  1.00 59.56 ? 762 VAL A CG1   1 
ATOM   5403 C  CG2   . VAL A 1 762 ? 124.071 96.709  84.218  1.00 59.56 ? 762 VAL A CG2   1 
ATOM   5404 N  N     . THR A 1 763 ? 124.069 95.913  80.447  1.00 62.41 ? 763 THR A N     1 
ATOM   5405 C  CA    . THR A 1 763 ? 124.564 94.762  79.708  1.00 62.41 ? 763 THR A CA    1 
ATOM   5406 C  C     . THR A 1 763 ? 126.007 94.447  80.083  1.00 62.41 ? 763 THR A C     1 
ATOM   5407 O  O     . THR A 1 763 ? 126.574 95.067  80.982  1.00 62.41 ? 763 THR A O     1 
ATOM   5408 C  CB    . THR A 1 763 ? 124.475 94.991  78.195  1.00 62.41 ? 763 THR A CB    1 
ATOM   5409 O  OG1   . THR A 1 763 ? 123.111 95.220  77.826  1.00 62.41 ? 763 THR A OG1   1 
ATOM   5410 C  CG2   . THR A 1 763 ? 124.981 93.771  77.456  1.00 62.41 ? 763 THR A CG2   1 
ATOM   5411 N  N     . TYR A 1 778 ? 124.368 91.666  87.163  1.00 56.36 ? 778 TYR A N     1 
ATOM   5412 C  CA    . TYR A 1 778 ? 123.005 91.205  86.930  1.00 56.36 ? 778 TYR A CA    1 
ATOM   5413 C  C     . TYR A 1 778 ? 122.266 90.979  88.244  1.00 56.36 ? 778 TYR A C     1 
ATOM   5414 O  O     . TYR A 1 778 ? 121.378 91.749  88.607  1.00 56.36 ? 778 TYR A O     1 
ATOM   5415 C  CB    . TYR A 1 778 ? 123.010 89.920  86.101  1.00 56.36 ? 778 TYR A CB    1 
ATOM   5416 C  CG    . TYR A 1 778 ? 123.390 90.131  84.656  1.00 56.36 ? 778 TYR A CG    1 
ATOM   5417 C  CD1   . TYR A 1 778 ? 123.352 91.397  84.088  1.00 56.36 ? 778 TYR A CD1   1 
ATOM   5418 C  CD2   . TYR A 1 778 ? 123.787 89.067  83.858  1.00 56.36 ? 778 TYR A CD2   1 
ATOM   5419 C  CE1   . TYR A 1 778 ? 123.699 91.598  82.769  1.00 56.36 ? 778 TYR A CE1   1 
ATOM   5420 C  CE2   . TYR A 1 778 ? 124.134 89.258  82.537  1.00 56.36 ? 778 TYR A CE2   1 
ATOM   5421 C  CZ    . TYR A 1 778 ? 124.090 90.526  81.998  1.00 56.36 ? 778 TYR A CZ    1 
ATOM   5422 O  OH    . TYR A 1 778 ? 124.436 90.726  80.682  1.00 56.36 ? 778 TYR A OH    1 
ATOM   5423 N  N     . GLY A 1 779 ? 122.644 89.926  88.957  1.00 53.64 ? 779 GLY A N     1 
ATOM   5424 C  CA    . GLY A 1 779 ? 122.004 89.566  90.203  1.00 53.64 ? 779 GLY A CA    1 
ATOM   5425 C  C     . GLY A 1 779 ? 121.143 88.322  90.069  1.00 53.64 ? 779 GLY A C     1 
ATOM   5426 O  O     . GLY A 1 779 ? 120.938 87.772  88.985  1.00 53.64 ? 779 GLY A O     1 
ATOM   5427 N  N     . LYS A 1 780 ? 120.625 87.880  91.217  1.00 51.70 ? 780 LYS A N     1 
ATOM   5428 C  CA    . LYS A 1 780 ? 119.848 86.645  91.263  1.00 51.70 ? 780 LYS A CA    1 
ATOM   5429 C  C     . LYS A 1 780 ? 118.584 86.743  90.418  1.00 51.70 ? 780 LYS A C     1 
ATOM   5430 O  O     . LYS A 1 780 ? 118.239 85.802  89.691  1.00 51.70 ? 780 LYS A O     1 
ATOM   5431 C  CB    . LYS A 1 780 ? 119.495 86.314  92.712  1.00 51.70 ? 780 LYS A CB    1 
ATOM   5432 C  CG    . LYS A 1 780 ? 120.632 85.706  93.505  1.00 51.70 ? 780 LYS A CG    1 
ATOM   5433 C  CD    . LYS A 1 780 ? 120.118 84.683  94.497  1.00 51.70 ? 780 LYS A CD    1 
ATOM   5434 C  CE    . LYS A 1 780 ? 119.584 83.449  93.796  1.00 51.70 ? 780 LYS A CE    1 
ATOM   5435 N  NZ    . LYS A 1 780 ? 119.293 82.373  94.778  1.00 51.70 ? 780 LYS A NZ    1 
ATOM   5436 N  N     . ARG A 1 781 ? 117.882 87.873  90.500  1.00 43.79 ? 781 ARG A N     1 
ATOM   5437 C  CA    . ARG A 1 781 ? 116.611 88.017  89.799  1.00 43.79 ? 781 ARG A CA    1 
ATOM   5438 C  C     . ARG A 1 781 ? 116.800 87.933  88.289  1.00 43.79 ? 781 ARG A C     1 
ATOM   5439 O  O     . ARG A 1 781 ? 116.112 87.162  87.609  1.00 43.79 ? 781 ARG A O     1 
ATOM   5440 C  CB    . ARG A 1 781 ? 115.957 89.339  90.197  1.00 43.79 ? 781 ARG A CB    1 
ATOM   5441 C  CG    . ARG A 1 781 ? 115.672 89.435  91.684  1.00 43.79 ? 781 ARG A CG    1 
ATOM   5442 C  CD    . ARG A 1 781 ? 114.987 90.736  92.051  1.00 43.79 ? 781 ARG A CD    1 
ATOM   5443 N  NE    . ARG A 1 781 ? 114.625 90.764  93.463  1.00 43.79 ? 781 ARG A NE    1 
ATOM   5444 C  CZ    . ARG A 1 781 ? 114.208 91.842  94.111  1.00 43.79 ? 781 ARG A CZ    1 
ATOM   5445 N  NH1   . ARG A 1 781 ? 114.083 93.010  93.501  1.00 43.79 ? 781 ARG A NH1   1 
ATOM   5446 N  NH2   . ARG A 1 781 ? 113.907 91.746  95.402  1.00 43.79 ? 781 ARG A NH2   1 
ATOM   5447 N  N     . VAL A 1 782 ? 117.741 88.709  87.749  1.00 47.27 ? 782 VAL A N     1 
ATOM   5448 C  CA    . VAL A 1 782 ? 117.961 88.712  86.307  1.00 47.27 ? 782 VAL A CA    1 
ATOM   5449 C  C     . VAL A 1 782 ? 118.559 87.386  85.855  1.00 47.27 ? 782 VAL A C     1 
ATOM   5450 O  O     . VAL A 1 782 ? 118.278 86.909  84.751  1.00 47.27 ? 782 VAL A O     1 
ATOM   5451 C  CB    . VAL A 1 782 ? 118.838 89.911  85.904  1.00 47.27 ? 782 VAL A CB    1 
ATOM   5452 C  CG1   . VAL A 1 782 ? 119.254 89.809  84.449  1.00 47.27 ? 782 VAL A CG1   1 
ATOM   5453 C  CG2   . VAL A 1 782 ? 118.090 91.210  86.146  1.00 47.27 ? 782 VAL A CG2   1 
ATOM   5454 N  N     . LYS A 1 783 ? 119.381 86.762  86.699  1.00 53.01 ? 783 LYS A N     1 
ATOM   5455 C  CA    . LYS A 1 783 ? 119.929 85.455  86.348  1.00 53.01 ? 783 LYS A CA    1 
ATOM   5456 C  C     . LYS A 1 783 ? 118.825 84.415  86.196  1.00 53.01 ? 783 LYS A C     1 
ATOM   5457 O  O     . LYS A 1 783 ? 118.806 83.658  85.217  1.00 53.01 ? 783 LYS A O     1 
ATOM   5458 C  CB    . LYS A 1 783 ? 120.946 85.011  87.400  1.00 53.01 ? 783 LYS A CB    1 
ATOM   5459 C  CG    . LYS A 1 783 ? 122.351 85.547  87.168  1.00 53.01 ? 783 LYS A CG    1 
ATOM   5460 C  CD    . LYS A 1 783 ? 123.274 85.193  88.319  1.00 53.01 ? 783 LYS A CD    1 
ATOM   5461 C  CE    . LYS A 1 783 ? 123.650 83.724  88.287  1.00 53.01 ? 783 LYS A CE    1 
ATOM   5462 N  NZ    . LYS A 1 783 ? 124.504 83.403  87.114  1.00 53.01 ? 783 LYS A NZ    1 
ATOM   5463 N  N     . ARG A 1 784 ? 117.888 84.369  87.147  1.00 49.68 ? 784 ARG A N     1 
ATOM   5464 C  CA    . ARG A 1 784 ? 116.772 83.433  87.031  1.00 49.68 ? 784 ARG A CA    1 
ATOM   5465 C  C     . ARG A 1 784 ? 115.880 83.773  85.842  1.00 49.68 ? 784 ARG A C     1 
ATOM   5466 O  O     . ARG A 1 784 ? 115.396 82.875  85.139  1.00 49.68 ? 784 ARG A O     1 
ATOM   5467 C  CB    . ARG A 1 784 ? 115.950 83.423  88.315  1.00 49.68 ? 784 ARG A CB    1 
ATOM   5468 C  CG    . ARG A 1 784 ? 114.638 82.694  88.147  1.00 49.68 ? 784 ARG A CG    1 
ATOM   5469 C  CD    . ARG A 1 784 ? 114.271 81.903  89.374  1.00 49.68 ? 784 ARG A CD    1 
ATOM   5470 N  NE    . ARG A 1 784 ? 113.063 81.118  89.165  1.00 49.68 ? 784 ARG A NE    1 
ATOM   5471 C  CZ    . ARG A 1 784 ? 111.842 81.630  89.138  1.00 49.68 ? 784 ARG A CZ    1 
ATOM   5472 N  NH1   . ARG A 1 784 ? 111.637 82.927  89.282  1.00 49.68 ? 784 ARG A NH1   1 
ATOM   5473 N  NH2   . ARG A 1 784 ? 110.803 80.821  88.953  1.00 49.68 ? 784 ARG A NH2   1 
ATOM   5474 N  N     . PHE A 1 785 ? 115.631 85.065  85.617  1.00 49.39 ? 785 PHE A N     1 
ATOM   5475 C  CA    . PHE A 1 785 ? 114.905 85.485  84.423  1.00 49.39 ? 785 PHE A CA    1 
ATOM   5476 C  C     . PHE A 1 785 ? 115.543 84.947  83.151  1.00 49.39 ? 785 PHE A C     1 
ATOM   5477 O  O     . PHE A 1 785 ? 114.850 84.396  82.289  1.00 49.39 ? 785 PHE A O     1 
ATOM   5478 C  CB    . PHE A 1 785 ? 114.808 87.008  84.388  1.00 49.39 ? 785 PHE A CB    1 
ATOM   5479 C  CG    . PHE A 1 785 ? 114.376 87.560  83.065  1.00 49.39 ? 785 PHE A CG    1 
ATOM   5480 C  CD1   . PHE A 1 785 ? 113.077 87.955  82.850  1.00 49.39 ? 785 PHE A CD1   1 
ATOM   5481 C  CD2   . PHE A 1 785 ? 115.309 87.777  82.065  1.00 49.39 ? 785 PHE A CD2   1 
ATOM   5482 C  CE1   . PHE A 1 785 ? 112.704 88.482  81.637  1.00 49.39 ? 785 PHE A CE1   1 
ATOM   5483 C  CE2   . PHE A 1 785 ? 114.942 88.301  80.859  1.00 49.39 ? 785 PHE A CE2   1 
ATOM   5484 C  CZ    . PHE A 1 785 ? 113.643 88.657  80.645  1.00 49.39 ? 785 PHE A CZ    1 
ATOM   5485 N  N     . LEU A 1 786 ? 116.855 85.117  82.998  1.00 55.16 ? 786 LEU A N     1 
ATOM   5486 C  CA    . LEU A 1 786 ? 117.513 84.651  81.783  1.00 55.16 ? 786 LEU A CA    1 
ATOM   5487 C  C     . LEU A 1 786 ? 117.490 83.131  81.697  1.00 55.16 ? 786 LEU A C     1 
ATOM   5488 O  O     . LEU A 1 786 ? 117.381 82.565  80.604  1.00 55.16 ? 786 LEU A O     1 
ATOM   5489 C  CB    . LEU A 1 786 ? 118.946 85.179  81.723  1.00 55.16 ? 786 LEU A CB    1 
ATOM   5490 C  CG    . LEU A 1 786 ? 119.094 86.660  81.373  1.00 55.16 ? 786 LEU A CG    1 
ATOM   5491 C  CD1   . LEU A 1 786 ? 120.556 87.044  81.254  1.00 55.16 ? 786 LEU A CD1   1 
ATOM   5492 C  CD2   . LEU A 1 786 ? 118.354 86.976  80.089  1.00 55.16 ? 786 LEU A CD2   1 
ATOM   5493 N  N     . LYS A 1 787 ? 117.587 82.453  82.842  1.00 53.77 ? 787 LYS A N     1 
ATOM   5494 C  CA    . LYS A 1 787 ? 117.550 80.995  82.834  1.00 53.77 ? 787 LYS A CA    1 
ATOM   5495 C  C     . LYS A 1 787 ? 116.192 80.472  82.382  1.00 53.77 ? 787 LYS A C     1 
ATOM   5496 O  O     . LYS A 1 787 ? 116.113 79.464  81.672  1.00 53.77 ? 787 LYS A O     1 
ATOM   5497 C  CB    . LYS A 1 787 ? 117.898 80.452  84.218  1.00 53.77 ? 787 LYS A CB    1 
ATOM   5498 C  CG    . LYS A 1 787 ? 118.146 78.956  84.246  1.00 53.77 ? 787 LYS A CG    1 
ATOM   5499 C  CD    . LYS A 1 787 ? 118.124 78.422  85.666  1.00 53.77 ? 787 LYS A CD    1 
ATOM   5500 C  CE    . LYS A 1 787 ? 117.933 76.918  85.678  1.00 53.77 ? 787 LYS A CE    1 
ATOM   5501 N  NZ    . LYS A 1 787 ? 117.069 76.481  86.808  1.00 53.77 ? 787 LYS A NZ    1 
ATOM   5502 N  N     . ASP A 1 788 ? 115.110 81.135  82.790  1.00 54.65 ? 788 ASP A N     1 
ATOM   5503 C  CA    . ASP A 1 788 ? 113.775 80.630  82.478  1.00 54.65 ? 788 ASP A CA    1 
ATOM   5504 C  C     . ASP A 1 788 ? 113.257 81.128  81.131  1.00 54.65 ? 788 ASP A C     1 
ATOM   5505 O  O     . ASP A 1 788 ? 112.856 80.323  80.285  1.00 54.65 ? 788 ASP A O     1 
ATOM   5506 C  CB    . ASP A 1 788 ? 112.793 81.008  83.590  1.00 54.65 ? 788 ASP A CB    1 
ATOM   5507 C  CG    . ASP A 1 788 ? 112.754 79.982  84.706  1.00 54.65 ? 788 ASP A CG    1 
ATOM   5508 O  OD1   . ASP A 1 788 ? 113.354 78.899  84.542  1.00 54.65 ? 788 ASP A OD1   1 
ATOM   5509 O  OD2   . ASP A 1 788 ? 112.118 80.257  85.744  1.00 54.65 ? 788 ASP A OD2   1 
ATOM   5510 N  N     . ARG A 1 789 ? 113.246 82.446  80.925  1.00 56.99 ? 789 ARG A N     1 
ATOM   5511 C  CA    . ARG A 1 789 ? 112.726 83.008  79.682  1.00 56.99 ? 789 ARG A CA    1 
ATOM   5512 C  C     . ARG A 1 789 ? 113.563 82.580  78.484  1.00 56.99 ? 789 ARG A C     1 
ATOM   5513 O  O     . ARG A 1 789 ? 113.019 82.270  77.418  1.00 56.99 ? 789 ARG A O     1 
ATOM   5514 C  CB    . ARG A 1 789 ? 112.674 84.531  79.786  1.00 56.99 ? 789 ARG A CB    1 
ATOM   5515 C  CG    . ARG A 1 789 ? 112.317 85.252  78.497  1.00 56.99 ? 789 ARG A CG    1 
ATOM   5516 C  CD    . ARG A 1 789 ? 110.870 85.009  78.116  1.00 56.99 ? 789 ARG A CD    1 
ATOM   5517 N  NE    . ARG A 1 789 ? 110.485 85.744  76.918  1.00 56.99 ? 789 ARG A NE    1 
ATOM   5518 C  CZ    . ARG A 1 789 ? 110.724 85.340  75.679  1.00 56.99 ? 789 ARG A CZ    1 
ATOM   5519 N  NH1   . ARG A 1 789 ? 111.356 84.205  75.432  1.00 56.99 ? 789 ARG A NH1   1 
ATOM   5520 N  NH2   . ARG A 1 789 ? 110.318 86.094  74.662  1.00 56.99 ? 789 ARG A NH2   1 
ATOM   5521 N  N     . TYR A 1 790 ? 114.882 82.555  78.636  1.00 59.80 ? 790 TYR A N     1 
ATOM   5522 C  CA    . TYR A 1 790 ? 115.798 82.167  77.573  1.00 59.80 ? 790 TYR A CA    1 
ATOM   5523 C  C     . TYR A 1 790 ? 116.568 80.916  77.995  1.00 59.80 ? 790 TYR A C     1 
ATOM   5524 O  O     . TYR A 1 790 ? 116.322 80.337  79.056  1.00 59.80 ? 790 TYR A O     1 
ATOM   5525 C  CB    . TYR A 1 790 ? 116.730 83.327  77.225  1.00 59.80 ? 790 TYR A CB    1 
ATOM   5526 C  CG    . TYR A 1 790 ? 116.004 84.513  76.636  1.00 59.80 ? 790 TYR A CG    1 
ATOM   5527 C  CD1   . TYR A 1 790 ? 115.301 84.393  75.449  1.00 59.80 ? 790 TYR A CD1   1 
ATOM   5528 C  CD2   . TYR A 1 790 ? 116.015 85.747  77.270  1.00 59.80 ? 790 TYR A CD2   1 
ATOM   5529 C  CE1   . TYR A 1 790 ? 114.634 85.468  74.905  1.00 59.80 ? 790 TYR A CE1   1 
ATOM   5530 C  CE2   . TYR A 1 790 ? 115.349 86.829  76.733  1.00 59.80 ? 790 TYR A CE2   1 
ATOM   5531 C  CZ    . TYR A 1 790 ? 114.660 86.683  75.550  1.00 59.80 ? 790 TYR A CZ    1 
ATOM   5532 O  OH    . TYR A 1 790 ? 113.992 87.751  75.002  1.00 59.80 ? 790 TYR A OH    1 
ATOM   5533 N  N     . GLY A 1 791 ? 117.506 80.498  77.145  1.00 66.28 ? 791 GLY A N     1 
ATOM   5534 C  CA    . GLY A 1 791 ? 118.168 79.220  77.358  1.00 66.28 ? 791 GLY A CA    1 
ATOM   5535 C  C     . GLY A 1 791 ? 119.011 79.182  78.618  1.00 66.28 ? 791 GLY A C     1 
ATOM   5536 O  O     . GLY A 1 791 ? 118.943 78.228  79.397  1.00 66.28 ? 791 GLY A O     1 
ATOM   5537 N  N     . SER A 1 792 ? 119.814 80.217  78.838  1.00 69.40 ? 792 SER A N     1 
ATOM   5538 C  CA    . SER A 1 792 ? 120.784 80.207  79.927  1.00 69.40 ? 792 SER A CA    1 
ATOM   5539 C  C     . SER A 1 792 ? 120.978 81.635  80.423  1.00 69.40 ? 792 SER A C     1 
ATOM   5540 O  O     . SER A 1 792 ? 120.319 82.569  79.955  1.00 69.40 ? 792 SER A O     1 
ATOM   5541 C  CB    . SER A 1 792 ? 122.105 79.579  79.471  1.00 69.40 ? 792 SER A CB    1 
ATOM   5542 O  OG    . SER A 1 792 ? 123.088 79.664  80.488  1.00 69.40 ? 792 SER A OG    1 
ATOM   5543 N  N     . SER A 1 793 ? 121.892 81.801  81.377  1.00 72.44 ? 793 SER A N     1 
ATOM   5544 C  CA    . SER A 1 793 ? 122.175 83.092  81.990  1.00 72.44 ? 793 SER A CA    1 
ATOM   5545 C  C     . SER A 1 793 ? 123.442 83.743  81.453  1.00 72.44 ? 793 SER A C     1 
ATOM   5546 O  O     . SER A 1 793 ? 123.457 84.955  81.221  1.00 72.44 ? 793 SER A O     1 
ATOM   5547 C  CB    . SER A 1 793 ? 122.288 82.937  83.509  1.00 72.44 ? 793 SER A CB    1 
ATOM   5548 O  OG    . SER A 1 793 ? 123.044 81.788  83.845  1.00 72.44 ? 793 SER A OG    1 
ATOM   5549 N  N     . ASN A 1 794 ? 124.510 82.970  81.256  1.00 78.36 ? 794 ASN A N     1 
ATOM   5550 C  CA    . ASN A 1 794 ? 125.770 83.502  80.737  1.00 78.36 ? 794 ASN A CA    1 
ATOM   5551 C  C     . ASN A 1 794 ? 125.704 83.551  79.210  1.00 78.36 ? 794 ASN A C     1 
ATOM   5552 O  O     . ASN A 1 794 ? 126.275 82.726  78.494  1.00 78.36 ? 794 ASN A O     1 
ATOM   5553 C  CB    . ASN A 1 794 ? 126.945 82.664  81.221  1.00 78.36 ? 794 ASN A CB    1 
ATOM   5554 C  CG    . ASN A 1 794 ? 128.259 83.416  81.163  1.00 78.36 ? 794 ASN A CG    1 
ATOM   5555 O  OD1   . ASN A 1 794 ? 128.348 84.566  81.592  1.00 78.36 ? 794 ASN A OD1   1 
ATOM   5556 N  ND2   . ASN A 1 794 ? 129.288 82.768  80.630  1.00 78.36 ? 794 ASN A ND2   1 
ATOM   5557 N  N     . VAL A 1 795 ? 124.978 84.548  78.713  1.00 75.49 ? 795 VAL A N     1 
ATOM   5558 C  CA    . VAL A 1 795 ? 124.743 84.703  77.283  1.00 75.49 ? 795 VAL A CA    1 
ATOM   5559 C  C     . VAL A 1 795 ? 124.923 86.169  76.909  1.00 75.49 ? 795 VAL A C     1 
ATOM   5560 O  O     . VAL A 1 795 ? 124.522 87.062  77.663  1.00 75.49 ? 795 VAL A O     1 
ATOM   5561 C  CB    . VAL A 1 795 ? 123.343 84.197  76.883  1.00 75.49 ? 795 VAL A CB    1 
ATOM   5562 C  CG1   . VAL A 1 795 ? 122.258 84.933  77.656  1.00 75.49 ? 795 VAL A CG1   1 
ATOM   5563 C  CG2   . VAL A 1 795 ? 123.133 84.336  75.391  1.00 75.49 ? 795 VAL A CG2   1 
ATOM   5564 N  N     . ARG A 1 796 ? 125.552 86.414  75.763  1.00 75.02 ? 796 ARG A N     1 
ATOM   5565 C  CA    . ARG A 1 796 ? 125.721 87.761  75.242  1.00 75.02 ? 796 ARG A CA    1 
ATOM   5566 C  C     . ARG A 1 796 ? 124.462 88.210  74.503  1.00 75.02 ? 796 ARG A C     1 
ATOM   5567 O  O     . ARG A 1 796 ? 123.606 87.404  74.129  1.00 75.02 ? 796 ARG A O     1 
ATOM   5568 C  CB    . ARG A 1 796 ? 126.932 87.826  74.310  1.00 75.02 ? 796 ARG A CB    1 
ATOM   5569 C  CG    . ARG A 1 796 ? 128.145 87.053  74.809  1.00 75.02 ? 796 ARG A CG    1 
ATOM   5570 C  CD    . ARG A 1 796 ? 129.216 86.948  73.731  1.00 75.02 ? 796 ARG A CD    1 
ATOM   5571 N  NE    . ARG A 1 796 ? 129.830 85.625  73.695  1.00 75.02 ? 796 ARG A NE    1 
ATOM   5572 C  CZ    . ARG A 1 796 ? 130.520 85.142  72.670  1.00 75.02 ? 796 ARG A CZ    1 
ATOM   5573 N  NH1   . ARG A 1 796 ? 130.712 85.852  71.570  1.00 75.02 ? 796 ARG A NH1   1 
ATOM   5574 N  NH2   . ARG A 1 796 ? 131.030 83.917  72.751  1.00 75.02 ? 796 ARG A NH2   1 
ATOM   5575 N  N     . PHE A 1 797 ? 124.359 89.521  74.290  1.00 68.63 ? 797 PHE A N     1 
ATOM   5576 C  CA    . PHE A 1 797 ? 123.207 90.122  73.630  1.00 68.63 ? 797 PHE A CA    1 
ATOM   5577 C  C     . PHE A 1 797 ? 123.672 90.920  72.423  1.00 68.63 ? 797 PHE A C     1 
ATOM   5578 O  O     . PHE A 1 797 ? 124.673 91.639  72.500  1.00 68.63 ? 797 PHE A O     1 
ATOM   5579 C  CB    . PHE A 1 797 ? 122.425 91.023  74.592  1.00 68.63 ? 797 PHE A CB    1 
ATOM   5580 C  CG    . PHE A 1 797 ? 122.138 90.384  75.921  1.00 68.63 ? 797 PHE A CG    1 
ATOM   5581 C  CD1   . PHE A 1 797 ? 120.997 89.621  76.104  1.00 68.63 ? 797 PHE A CD1   1 
ATOM   5582 C  CD2   . PHE A 1 797 ? 123.005 90.546  76.986  1.00 68.63 ? 797 PHE A CD2   1 
ATOM   5583 C  CE1   . PHE A 1 797 ? 120.730 89.031  77.321  1.00 68.63 ? 797 PHE A CE1   1 
ATOM   5584 C  CE2   . PHE A 1 797 ? 122.742 89.958  78.205  1.00 68.63 ? 797 PHE A CE2   1 
ATOM   5585 C  CZ    . PHE A 1 797 ? 121.603 89.199  78.372  1.00 68.63 ? 797 PHE A CZ    1 
ATOM   5586 N  N     . LEU A 1 798 ? 122.943 90.797  71.315  1.00 65.85 ? 798 LEU A N     1 
ATOM   5587 C  CA    . LEU A 1 798 ? 123.269 91.487  70.076  1.00 65.85 ? 798 LEU A CA    1 
ATOM   5588 C  C     . LEU A 1 798 ? 122.022 92.143  69.504  1.00 65.85 ? 798 LEU A C     1 
ATOM   5589 O  O     . LEU A 1 798 ? 120.942 91.546  69.499  1.00 65.85 ? 798 LEU A O     1 
ATOM   5590 C  CB    . LEU A 1 798 ? 123.869 90.525  69.045  1.00 65.85 ? 798 LEU A CB    1 
ATOM   5591 C  CG    . LEU A 1 798 ? 124.283 91.145  67.710  1.00 65.85 ? 798 LEU A CG    1 
ATOM   5592 C  CD1   . LEU A 1 798 ? 125.342 92.213  67.925  1.00 65.85 ? 798 LEU A CD1   1 
ATOM   5593 C  CD2   . LEU A 1 798 ? 124.783 90.074  66.753  1.00 65.85 ? 798 LEU A CD2   1 
ATOM   5594 N  N     . VAL A 1 799 ? 122.181 93.374  69.011  1.00 67.72 ? 799 VAL A N     1 
ATOM   5595 C  CA    . VAL A 1 799 ? 121.051 94.103  68.447  1.00 67.72 ? 799 VAL A CA    1 
ATOM   5596 C  C     . VAL A 1 799 ? 120.718 93.561  67.058  1.00 67.72 ? 799 VAL A C     1 
ATOM   5597 O  O     . VAL A 1 799 ? 121.579 93.065  66.322  1.00 67.72 ? 799 VAL A O     1 
ATOM   5598 C  CB    . VAL A 1 799 ? 121.352 95.611  68.406  1.00 67.72 ? 799 VAL A CB    1 
ATOM   5599 C  CG1   . VAL A 1 799 ? 122.504 95.904  67.454  1.00 67.72 ? 799 VAL A CG1   1 
ATOM   5600 C  CG2   . VAL A 1 799 ? 120.110 96.414  68.032  1.00 67.72 ? 799 VAL A CG2   1 
ATOM   5601 N  N     . ALA A 1 800 ? 119.438 93.649  66.703  1.00 72.77 ? 800 ALA A N     1 
ATOM   5602 C  CA    . ALA A 1 800 ? 118.972 93.179  65.407  1.00 72.77 ? 800 ALA A CA    1 
ATOM   5603 C  C     . ALA A 1 800 ? 117.692 93.916  65.044  1.00 72.77 ? 800 ALA A C     1 
ATOM   5604 O  O     . ALA A 1 800 ? 117.049 94.536  65.894  1.00 72.77 ? 800 ALA A O     1 
ATOM   5605 C  CB    . ALA A 1 800 ? 118.743 91.664  65.407  1.00 72.77 ? 800 ALA A CB    1 
ATOM   5606 N  N     . SER A 1 801 ? 117.333 93.833  63.762  1.00 76.80 ? 801 SER A N     1 
ATOM   5607 C  CA    . SER A 1 801 ? 116.128 94.462  63.202  1.00 76.80 ? 801 SER A CA    1 
ATOM   5608 C  C     . SER A 1 801 ? 116.194 95.960  63.500  1.00 76.80 ? 801 SER A C     1 
ATOM   5609 O  O     . SER A 1 801 ? 117.238 96.580  63.258  1.00 76.80 ? 801 SER A O     1 
ATOM   5610 C  CB    . SER A 1 801 ? 114.893 93.742  63.728  1.00 76.80 ? 801 SER A CB    1 
ATOM   5611 O  OG    . SER A 1 801 ? 113.710 94.303  63.188  1.00 76.80 ? 801 SER A OG    1 
ATOM   5612 N  N     . MET A 1 802 ? 115.129 96.574  64.019  1.00 78.02 ? 802 MET A N     1 
ATOM   5613 C  CA    . MET A 1 802 ? 115.103 98.004  64.318  1.00 78.02 ? 802 MET A CA    1 
ATOM   5614 C  C     . MET A 1 802 ? 114.700 98.190  65.784  1.00 78.02 ? 802 MET A C     1 
ATOM   5615 O  O     . MET A 1 802 ? 113.526 98.367  66.115  1.00 78.02 ? 802 MET A O     1 
ATOM   5616 C  CB    . MET A 1 802 ? 114.163 98.748  63.366  1.00 78.02 ? 802 MET A CB    1 
ATOM   5617 C  CG    . MET A 1 802 ? 112.858 98.024  63.074  1.00 78.02 ? 802 MET A CG    1 
ATOM   5618 S  SD    . MET A 1 802 ? 111.545 99.146  62.556  1.00 78.02 ? 802 MET A SD    1 
ATOM   5619 C  CE    . MET A 1 802 ? 111.169 99.965  64.103  1.00 78.02 ? 802 MET A CE    1 
ATOM   5620 N  N     . GLY A 1 803 ? 115.696 98.153  66.667  1.00 72.16 ? 803 GLY A N     1 
ATOM   5621 C  CA    . GLY A 1 803 ? 115.486 98.315  68.088  1.00 72.16 ? 803 GLY A CA    1 
ATOM   5622 C  C     . GLY A 1 803 ? 115.223 97.031  68.845  1.00 72.16 ? 803 GLY A C     1 
ATOM   5623 O  O     . GLY A 1 803 ? 115.218 97.052  70.081  1.00 72.16 ? 803 GLY A O     1 
ATOM   5624 N  N     . PHE A 1 804 ? 115.005 95.920  68.149  1.00 68.64 ? 804 PHE A N     1 
ATOM   5625 C  CA    . PHE A 1 804 ? 114.806 94.646  68.818  1.00 68.64 ? 804 PHE A CA    1 
ATOM   5626 C  C     . PHE A 1 804 ? 116.149 94.047  69.220  1.00 68.64 ? 804 PHE A C     1 
ATOM   5627 O  O     . PHE A 1 804 ? 117.209 94.446  68.733  1.00 68.64 ? 804 PHE A O     1 
ATOM   5628 C  CB    . PHE A 1 804 ? 114.037 93.680  67.917  1.00 68.64 ? 804 PHE A CB    1 
ATOM   5629 C  CG    . PHE A 1 804 ? 112.549 93.880  67.946  1.00 68.64 ? 804 PHE A CG    1 
ATOM   5630 C  CD1   . PHE A 1 804 ? 111.989 95.077  67.531  1.00 68.64 ? 804 PHE A CD1   1 
ATOM   5631 C  CD2   . PHE A 1 804 ? 111.709 92.872  68.385  1.00 68.64 ? 804 PHE A CD2   1 
ATOM   5632 C  CE1   . PHE A 1 804 ? 110.621 95.265  67.556  1.00 68.64 ? 804 PHE A CE1   1 
ATOM   5633 C  CE2   . PHE A 1 804 ? 110.340 93.055  68.411  1.00 68.64 ? 804 PHE A CE2   1 
ATOM   5634 C  CZ    . PHE A 1 804 ? 109.796 94.253  67.996  1.00 68.64 ? 804 PHE A CZ    1 
ATOM   5635 N  N     . VAL A 1 805 ? 116.097 93.080  70.131  1.00 62.04 ? 805 VAL A N     1 
ATOM   5636 C  CA    . VAL A 1 805 ? 117.296 92.447  70.664  1.00 62.04 ? 805 VAL A CA    1 
ATOM   5637 C  C     . VAL A 1 805 ? 117.153 90.939  70.533  1.00 62.04 ? 805 VAL A C     1 
ATOM   5638 O  O     . VAL A 1 805 ? 116.153 90.364  70.975  1.00 62.04 ? 805 VAL A O     1 
ATOM   5639 C  CB    . VAL A 1 805 ? 117.543 92.843  72.131  1.00 62.04 ? 805 VAL A CB    1 
ATOM   5640 C  CG1   . VAL A 1 805 ? 118.515 91.875  72.790  1.00 62.04 ? 805 VAL A CG1   1 
ATOM   5641 C  CG2   . VAL A 1 805 ? 118.060 94.268  72.207  1.00 62.04 ? 805 VAL A CG2   1 
ATOM   5642 N  N     . THR A 1 806 ? 118.151 90.304  69.926  1.00 68.26 ? 806 THR A N     1 
ATOM   5643 C  CA    . THR A 1 806 ? 118.198 88.856  69.788  1.00 68.26 ? 806 THR A CA    1 
ATOM   5644 C  C     . THR A 1 806 ? 119.237 88.293  70.747  1.00 68.26 ? 806 THR A C     1 
ATOM   5645 O  O     . THR A 1 806 ? 120.386 88.743  70.760  1.00 68.26 ? 806 THR A O     1 
ATOM   5646 C  CB    . THR A 1 806 ? 118.531 88.451  68.352  1.00 68.26 ? 806 THR A CB    1 
ATOM   5647 O  OG1   . THR A 1 806 ? 119.775 89.047  67.963  1.00 68.26 ? 806 THR A OG1   1 
ATOM   5648 C  CG2   . THR A 1 806 ? 117.434 88.905  67.402  1.00 68.26 ? 806 THR A CG2   1 
ATOM   5649 N  N     . VAL A 1 807 ? 118.829 87.313  71.545  1.00 68.59 ? 807 VAL A N     1 
ATOM   5650 C  CA    . VAL A 1 807 ? 119.717 86.700  72.525  1.00 68.59 ? 807 VAL A CA    1 
ATOM   5651 C  C     . VAL A 1 807 ? 120.474 85.563  71.850  1.00 68.59 ? 807 VAL A C     1 
ATOM   5652 O  O     . VAL A 1 807 ? 119.877 84.558  71.449  1.00 68.59 ? 807 VAL A O     1 
ATOM   5653 C  CB    . VAL A 1 807 ? 118.928 86.202  73.743  1.00 68.59 ? 807 VAL A CB    1 
ATOM   5654 C  CG1   . VAL A 1 807 ? 119.826 85.419  74.677  1.00 68.59 ? 807 VAL A CG1   1 
ATOM   5655 C  CG2   . VAL A 1 807 ? 118.293 87.376  74.469  1.00 68.59 ? 807 VAL A CG2   1 
ATOM   5656 N  N     . THR A 1 808 ? 121.791 85.717  71.727  1.00 74.30 ? 808 THR A N     1 
ATOM   5657 C  CA    . THR A 1 808 ? 122.630 84.780  70.985  1.00 74.30 ? 808 THR A CA    1 
ATOM   5658 C  C     . THR A 1 808 ? 123.645 84.159  71.935  1.00 74.30 ? 808 THR A C     1 
ATOM   5659 O  O     . THR A 1 808 ? 124.463 84.870  72.527  1.00 74.30 ? 808 THR A O     1 
ATOM   5660 C  CB    . THR A 1 808 ? 123.338 85.476  69.822  1.00 74.30 ? 808 THR A CB    1 
ATOM   5661 O  OG1   . THR A 1 808 ? 124.210 86.493  70.332  1.00 74.30 ? 808 THR A OG1   1 
ATOM   5662 C  CG2   . THR A 1 808 ? 122.324 86.111  68.885  1.00 74.30 ? 808 THR A CG2   1 
ATOM   5663 N  N     . THR A 1 809 ? 123.600 82.838  72.069  1.00 77.98 ? 809 THR A N     1 
ATOM   5664 C  CA    . THR A 1 809 ? 124.559 82.120  72.898  1.00 77.98 ? 809 THR A CA    1 
ATOM   5665 C  C     . THR A 1 809 ? 125.780 81.714  72.079  1.00 77.98 ? 809 THR A C     1 
ATOM   5666 O  O     . THR A 1 809 ? 126.192 82.431  71.168  1.00 77.98 ? 809 THR A O     1 
ATOM   5667 C  CB    . THR A 1 809 ? 123.933 80.864  73.535  1.00 77.98 ? 809 THR A CB    1 
ATOM   5668 O  OG1   . THR A 1 809 ? 124.854 80.287  74.469  1.00 77.98 ? 809 THR A OG1   1 
ATOM   5669 C  CG2   . THR A 1 809 ? 123.593 79.838  72.468  1.00 77.98 ? 809 THR A CG2   1 
ATOM   5670 N  N     . ALA A 1 815 ? 128.802 93.064  69.468  1.00 66.14 ? 815 ALA A N     1 
ATOM   5671 C  CA    . ALA A 1 815 ? 127.884 92.996  70.597  1.00 66.14 ? 815 ALA A CA    1 
ATOM   5672 C  C     . ALA A 1 815 ? 127.788 94.343  71.304  1.00 66.14 ? 815 ALA A C     1 
ATOM   5673 O  O     . ALA A 1 815 ? 128.385 95.326  70.869  1.00 66.14 ? 815 ALA A O     1 
ATOM   5674 C  CB    . ALA A 1 815 ? 128.320 91.915  71.571  1.00 66.14 ? 815 ALA A CB    1 
ATOM   5675 N  N     . LEU A 1 816 ? 127.036 94.380  72.401  1.00 68.84 ? 816 LEU A N     1 
ATOM   5676 C  CA    . LEU A 1 816 ? 126.820 95.598  73.168  1.00 68.84 ? 816 LEU A CA    1 
ATOM   5677 C  C     . LEU A 1 816 ? 127.203 95.358  74.619  1.00 68.84 ? 816 LEU A C     1 
ATOM   5678 O  O     . LEU A 1 816 ? 127.056 94.246  75.133  1.00 68.84 ? 816 LEU A O     1 
ATOM   5679 C  CB    . LEU A 1 816 ? 125.359 96.058  73.084  1.00 68.84 ? 816 LEU A CB    1 
ATOM   5680 C  CG    . LEU A 1 816 ? 124.790 96.263  71.679  1.00 68.84 ? 816 LEU A CG    1 
ATOM   5681 C  CD1   . LEU A 1 816 ? 123.289 96.485  71.736  1.00 68.84 ? 816 LEU A CD1   1 
ATOM   5682 C  CD2   . LEU A 1 816 ? 125.481 97.424  70.982  1.00 68.84 ? 816 LEU A CD2   1 
ATOM   5683 N  N     . VAL A 1 817 ? 127.712 96.403  75.271  1.00 68.70 ? 817 VAL A N     1 
ATOM   5684 C  CA    . VAL A 1 817 ? 128.055 96.360  76.686  1.00 68.70 ? 817 VAL A CA    1 
ATOM   5685 C  C     . VAL A 1 817 ? 127.607 97.658  77.342  1.00 68.70 ? 817 VAL A C     1 
ATOM   5686 O  O     . VAL A 1 817 ? 127.719 98.743  76.761  1.00 68.70 ? 817 VAL A O     1 
ATOM   5687 C  CB    . VAL A 1 817 ? 129.566 96.126  76.915  1.00 68.70 ? 817 VAL A CB    1 
ATOM   5688 C  CG1   . VAL A 1 817 ? 129.944 94.696  76.565  1.00 68.70 ? 817 VAL A CG1   1 
ATOM   5689 C  CG2   . VAL A 1 817 ? 130.388 97.107  76.095  1.00 68.70 ? 817 VAL A CG2   1 
ATOM   5690 N  N     . GLY A 1 818 ? 127.089 97.540  78.563  1.00 66.47 ? 818 GLY A N     1 
ATOM   5691 C  CA    . GLY A 1 818 ? 126.663 98.698  79.324  1.00 66.47 ? 818 GLY A CA    1 
ATOM   5692 C  C     . GLY A 1 818 ? 125.520 99.470  78.697  1.00 66.47 ? 818 GLY A C     1 
ATOM   5693 O  O     . GLY A 1 818 ? 125.574 100.700 78.607  1.00 66.47 ? 818 GLY A O     1 
ATOM   5694 N  N     . LYS A 1 819 ? 124.481 98.764  78.260  1.00 64.76 ? 819 LYS A N     1 
ATOM   5695 C  CA    . LYS A 1 819 ? 123.343 99.379  77.598  1.00 64.76 ? 819 LYS A CA    1 
ATOM   5696 C  C     . LYS A 1 819 ? 122.049 99.050  78.332  1.00 64.76 ? 819 LYS A C     1 
ATOM   5697 O  O     . LYS A 1 819 ? 121.964 98.083  79.094  1.00 64.76 ? 819 LYS A O     1 
ATOM   5698 C  CB    . LYS A 1 819 ? 123.237 98.926  76.135  1.00 64.76 ? 819 LYS A CB    1 
ATOM   5699 C  CG    . LYS A 1 819 ? 124.535 99.032  75.353  1.00 64.76 ? 819 LYS A CG    1 
ATOM   5700 C  CD    . LYS A 1 819 ? 125.047 100.460 75.325  1.00 64.76 ? 819 LYS A CD    1 
ATOM   5701 C  CE    . LYS A 1 819 ? 126.203 100.608 74.351  1.00 64.76 ? 819 LYS A CE    1 
ATOM   5702 N  NZ    . LYS A 1 819 ? 127.396 99.833  74.786  1.00 64.76 ? 819 LYS A NZ    1 
ATOM   5703 N  N     . ARG A 1 820 ? 121.038 99.878  78.082  1.00 59.39 ? 820 ARG A N     1 
ATOM   5704 C  CA    . ARG A 1 820 ? 119.703 99.698  78.640  1.00 59.39 ? 820 ARG A CA    1 
ATOM   5705 C  C     . ARG A 1 820 ? 118.942 98.679  77.800  1.00 59.39 ? 820 ARG A C     1 
ATOM   5706 O  O     . ARG A 1 820 ? 118.674 98.920  76.618  1.00 59.39 ? 820 ARG A O     1 
ATOM   5707 C  CB    . ARG A 1 820 ? 118.955 101.031 78.653  1.00 59.39 ? 820 ARG A CB    1 
ATOM   5708 C  CG    . ARG A 1 820 ? 119.511 102.100 79.584  1.00 59.39 ? 820 ARG A CG    1 
ATOM   5709 C  CD    . ARG A 1 820 ? 119.046 101.953 81.029  1.00 59.39 ? 820 ARG A CD    1 
ATOM   5710 N  NE    . ARG A 1 820 ? 119.858 101.052 81.835  1.00 59.39 ? 820 ARG A NE    1 
ATOM   5711 C  CZ    . ARG A 1 820 ? 119.546 100.689 83.071  1.00 59.39 ? 820 ARG A CZ    1 
ATOM   5712 N  NH1   . ARG A 1 820 ? 118.473 101.163 83.680  1.00 59.39 ? 820 ARG A NH1   1 
ATOM   5713 N  NH2   . ARG A 1 820 ? 120.336 99.838  83.717  1.00 59.39 ? 820 ARG A NH2   1 
ATOM   5714 N  N     . LEU A 1 821 ? 118.592 97.548  78.403  1.00 58.39 ? 821 LEU A N     1 
ATOM   5715 C  CA    . LEU A 1 821 ? 117.749 96.550  77.762  1.00 58.39 ? 821 LEU A CA    1 
ATOM   5716 C  C     . LEU A 1 821 ? 116.444 96.425  78.535  1.00 58.39 ? 821 LEU A C     1 
ATOM   5717 O  O     . LEU A 1 821 ? 116.448 96.221  79.753  1.00 58.39 ? 821 LEU A O     1 
ATOM   5718 C  CB    . LEU A 1 821 ? 118.451 95.196  77.675  1.00 58.39 ? 821 LEU A CB    1 
ATOM   5719 C  CG    . LEU A 1 821 ? 119.624 95.132  76.699  1.00 58.39 ? 821 LEU A CG    1 
ATOM   5720 C  CD1   . LEU A 1 821 ? 120.118 93.706  76.549  1.00 58.39 ? 821 LEU A CD1   1 
ATOM   5721 C  CD2   . LEU A 1 821 ? 119.219 95.706  75.355  1.00 58.39 ? 821 LEU A CD2   1 
ATOM   5722 N  N     . TYR A 1 822 ? 115.328 96.547  77.820  1.00 56.61 ? 822 TYR A N     1 
ATOM   5723 C  CA    . TYR A 1 822 ? 114.018 96.714  78.428  1.00 56.61 ? 822 TYR A CA    1 
ATOM   5724 C  C     . TYR A 1 822 ? 113.104 95.581  77.990  1.00 56.61 ? 822 TYR A C     1 
ATOM   5725 O  O     . TYR A 1 822 ? 113.119 95.181  76.824  1.00 56.61 ? 822 TYR A O     1 
ATOM   5726 C  CB    . TYR A 1 822 ? 113.407 98.054  78.020  1.00 56.61 ? 822 TYR A CB    1 
ATOM   5727 C  CG    . TYR A 1 822 ? 114.141 99.261  78.557  1.00 56.61 ? 822 TYR A CG    1 
ATOM   5728 C  CD1   . TYR A 1 822 ? 115.060 99.149  79.586  1.00 56.61 ? 822 TYR A CD1   1 
ATOM   5729 C  CD2   . TYR A 1 822 ? 113.937 100.511 78.006  1.00 56.61 ? 822 TYR A CD2   1 
ATOM   5730 C  CE1   . TYR A 1 822 ? 115.739 100.255 80.058  1.00 56.61 ? 822 TYR A CE1   1 
ATOM   5731 C  CE2   . TYR A 1 822 ? 114.613 101.618 78.473  1.00 56.61 ? 822 TYR A CE2   1 
ATOM   5732 C  CZ    . TYR A 1 822 ? 115.507 101.487 79.500  1.00 56.61 ? 822 TYR A CZ    1 
ATOM   5733 O  OH    . TYR A 1 822 ? 116.173 102.598 79.963  1.00 56.61 ? 822 TYR A OH    1 
ATOM   5734 N  N     . TYR A 1 823 ? 112.300 95.075  78.922  1.00 54.85 ? 823 TYR A N     1 
ATOM   5735 C  CA    . TYR A 1 823 ? 111.352 94.001  78.647  1.00 54.85 ? 823 TYR A CA    1 
ATOM   5736 C  C     . TYR A 1 823 ? 109.967 94.597  78.425  1.00 54.85 ? 823 TYR A C     1 
ATOM   5737 O  O     . TYR A 1 823 ? 109.434 95.283  79.302  1.00 54.85 ? 823 TYR A O     1 
ATOM   5738 C  CB    . TYR A 1 823 ? 111.334 92.990  79.793  1.00 54.85 ? 823 TYR A CB    1 
ATOM   5739 C  CG    . TYR A 1 823 ? 110.687 91.669  79.451  1.00 54.85 ? 823 TYR A CG    1 
ATOM   5740 C  CD1   . TYR A 1 823 ? 111.456 90.549  79.201  1.00 54.85 ? 823 TYR A CD1   1 
ATOM   5741 C  CD2   . TYR A 1 823 ? 109.307 91.534  79.412  1.00 54.85 ? 823 TYR A CD2   1 
ATOM   5742 C  CE1   . TYR A 1 823 ? 110.878 89.336  78.895  1.00 54.85 ? 823 TYR A CE1   1 
ATOM   5743 C  CE2   . TYR A 1 823 ? 108.718 90.324  79.112  1.00 54.85 ? 823 TYR A CE2   1 
ATOM   5744 C  CZ    . TYR A 1 823 ? 109.510 89.228  78.855  1.00 54.85 ? 823 TYR A CZ    1 
ATOM   5745 O  OH    . TYR A 1 823 ? 108.938 88.016  78.553  1.00 54.85 ? 823 TYR A OH    1 
ATOM   5746 N  N     . HIS A 1 824 ? 109.391 94.339  77.252  1.00 51.94 ? 824 HIS A N     1 
ATOM   5747 C  CA    . HIS A 1 824 ? 108.091 94.898  76.883  1.00 51.94 ? 824 HIS A CA    1 
ATOM   5748 C  C     . HIS A 1 824 ? 107.379 93.900  75.982  1.00 51.94 ? 824 HIS A C     1 
ATOM   5749 O  O     . HIS A 1 824 ? 107.771 93.723  74.825  1.00 51.94 ? 824 HIS A O     1 
ATOM   5750 C  CB    . HIS A 1 824 ? 108.245 96.241  76.174  1.00 51.94 ? 824 HIS A CB    1 
ATOM   5751 C  CG    . HIS A 1 824 ? 108.761 97.340  77.049  1.00 51.94 ? 824 HIS A CG    1 
ATOM   5752 N  ND1   . HIS A 1 824 ? 108.759 97.264  78.424  1.00 51.94 ? 824 HIS A ND1   1 
ATOM   5753 C  CD2   . HIS A 1 824 ? 109.301 98.542  76.740  1.00 51.94 ? 824 HIS A CD2   1 
ATOM   5754 C  CE1   . HIS A 1 824 ? 109.275 98.372  78.925  1.00 51.94 ? 824 HIS A CE1   1 
ATOM   5755 N  NE2   . HIS A 1 824 ? 109.611 99.164  77.924  1.00 51.94 ? 824 HIS A NE2   1 
ATOM   5756 N  N     . GLY A 1 825 ? 106.334 93.262  76.502  1.00 51.65 ? 825 GLY A N     1 
ATOM   5757 C  CA    . GLY A 1 825 ? 105.514 92.377  75.701  1.00 51.65 ? 825 GLY A CA    1 
ATOM   5758 C  C     . GLY A 1 825 ? 106.107 91.018  75.417  1.00 51.65 ? 825 GLY A C     1 
ATOM   5759 O  O     . GLY A 1 825 ? 105.586 90.303  74.555  1.00 51.65 ? 825 GLY A O     1 
ATOM   5760 N  N     . GLY A 1 826 ? 107.174 90.634  76.110  1.00 57.15 ? 826 GLY A N     1 
ATOM   5761 C  CA    . GLY A 1 826 ? 107.825 89.365  75.874  1.00 57.15 ? 826 GLY A CA    1 
ATOM   5762 C  C     . GLY A 1 826 ? 109.096 89.437  75.059  1.00 57.15 ? 826 GLY A C     1 
ATOM   5763 O  O     . GLY A 1 826 ? 109.667 88.386  74.744  1.00 57.15 ? 826 GLY A O     1 
ATOM   5764 N  N     . GLU A 1 827 ? 109.556 90.635  74.709  1.00 58.52 ? 827 GLU A N     1 
ATOM   5765 C  CA    . GLU A 1 827 ? 110.760 90.814  73.914  1.00 58.52 ? 827 GLU A CA    1 
ATOM   5766 C  C     . GLU A 1 827 ? 111.586 91.952  74.493  1.00 58.52 ? 827 GLU A C     1 
ATOM   5767 O  O     . GLU A 1 827 ? 111.036 92.938  74.989  1.00 58.52 ? 827 GLU A O     1 
ATOM   5768 C  CB    . GLU A 1 827 ? 110.421 91.112  72.449  1.00 58.52 ? 827 GLU A CB    1 
ATOM   5769 C  CG    . GLU A 1 827 ? 109.375 92.201  72.270  1.00 58.52 ? 827 GLU A CG    1 
ATOM   5770 C  CD    . GLU A 1 827 ? 108.022 91.656  71.858  1.00 58.52 ? 827 GLU A CD    1 
ATOM   5771 O  OE1   . GLU A 1 827 ? 107.522 90.729  72.527  1.00 58.52 ? 827 GLU A OE1   1 
ATOM   5772 O  OE2   . GLU A 1 827 ? 107.453 92.160  70.867  1.00 58.52 ? 827 GLU A OE2   1 
ATOM   5773 N  N     . LEU A 1 828 ? 112.906 91.806  74.436  1.00 56.87 ? 828 LEU A N     1 
ATOM   5774 C  CA    . LEU A 1 828 ? 113.789 92.885  74.852  1.00 56.87 ? 828 LEU A CA    1 
ATOM   5775 C  C     . LEU A 1 828 ? 113.881 93.945  73.764  1.00 56.87 ? 828 LEU A C     1 
ATOM   5776 O  O     . LEU A 1 828 ? 113.821 93.640  72.570  1.00 56.87 ? 828 LEU A O     1 
ATOM   5777 C  CB    . LEU A 1 828 ? 115.182 92.351  75.181  1.00 56.87 ? 828 LEU A CB    1 
ATOM   5778 C  CG    . LEU A 1 828 ? 115.403 91.663  76.531  1.00 56.87 ? 828 LEU A CG    1 
ATOM   5779 C  CD1   . LEU A 1 828 ? 114.652 90.349  76.645  1.00 56.87 ? 828 LEU A CD1   1 
ATOM   5780 C  CD2   . LEU A 1 828 ? 116.885 91.452  76.766  1.00 56.87 ? 828 LEU A CD2   1 
ATOM   5781 N  N     . VAL A 1 829 ? 114.018 95.204  74.181  1.00 58.57 ? 829 VAL A N     1 
ATOM   5782 C  CA    . VAL A 1 829 ? 114.174 96.319  73.259  1.00 58.57 ? 829 VAL A CA    1 
ATOM   5783 C  C     . VAL A 1 829 ? 115.343 97.175  73.726  1.00 58.57 ? 829 VAL A C     1 
ATOM   5784 O  O     . VAL A 1 829 ? 115.812 97.067  74.861  1.00 58.57 ? 829 VAL A O     1 
ATOM   5785 C  CB    . VAL A 1 829 ? 112.895 97.179  73.140  1.00 58.57 ? 829 VAL A CB    1 
ATOM   5786 C  CG1   . VAL A 1 829 ? 111.733 96.339  72.641  1.00 58.57 ? 829 VAL A CG1   1 
ATOM   5787 C  CG2   . VAL A 1 829 ? 112.564 97.834  74.464  1.00 58.57 ? 829 VAL A CG2   1 
ATOM   5788 N  N     . THR A 1 830 ? 115.824 98.021  72.822  1.00 62.79 ? 830 THR A N     1 
ATOM   5789 C  CA    . THR A 1 830 ? 116.880 98.960  73.158  1.00 62.79 ? 830 THR A CA    1 
ATOM   5790 C  C     . THR A 1 830 ? 116.285 100.253 73.713  1.00 62.79 ? 830 THR A C     1 
ATOM   5791 O  O     . THR A 1 830 ? 115.078 100.496 73.645  1.00 62.79 ? 830 THR A O     1 
ATOM   5792 C  CB    . THR A 1 830 ? 117.747 99.259  71.936  1.00 62.79 ? 830 THR A CB    1 
ATOM   5793 O  OG1   . THR A 1 830 ? 117.028 100.111 71.038  1.00 62.79 ? 830 THR A OG1   1 
ATOM   5794 C  CG2   . THR A 1 830 ? 118.123 97.974  71.221  1.00 62.79 ? 830 THR A CG2   1 
ATOM   5795 N  N     . HIS A 1 831 ? 117.163 101.091 74.268  1.00 61.23 ? 831 HIS A N     1 
ATOM   5796 C  CA    . HIS A 1 831 ? 116.736 102.375 74.814  1.00 61.23 ? 831 HIS A CA    1 
ATOM   5797 C  C     . HIS A 1 831 ? 116.071 103.237 73.748  1.00 61.23 ? 831 HIS A C     1 
ATOM   5798 O  O     . HIS A 1 831 ? 115.044 103.879 74.011  1.00 61.23 ? 831 HIS A O     1 
ATOM   5799 C  CB    . HIS A 1 831 ? 117.945 103.095 75.414  1.00 61.23 ? 831 HIS A CB    1 
ATOM   5800 C  CG    . HIS A 1 831 ? 117.597 104.203 76.360  1.00 61.23 ? 831 HIS A CG    1 
ATOM   5801 N  ND1   . HIS A 1 831 ? 116.582 105.103 76.119  1.00 61.23 ? 831 HIS A ND1   1 
ATOM   5802 C  CD2   . HIS A 1 831 ? 118.141 104.559 77.547  1.00 61.23 ? 831 HIS A CD2   1 
ATOM   5803 C  CE1   . HIS A 1 831 ? 116.513 105.962 77.121  1.00 61.23 ? 831 HIS A CE1   1 
ATOM   5804 N  NE2   . HIS A 1 831 ? 117.448 105.654 78.000  1.00 61.23 ? 831 HIS A NE2   1 
ATOM   5805 N  N     . ASP A 1 832 ? 116.636 103.249 72.540  1.00 63.50 ? 832 ASP A N     1 
ATOM   5806 C  CA    . ASP A 1 832 ? 116.076 104.058 71.464  1.00 63.50 ? 832 ASP A CA    1 
ATOM   5807 C  C     . ASP A 1 832 ? 114.673 103.597 71.097  1.00 63.50 ? 832 ASP A C     1 
ATOM   5808 O  O     . ASP A 1 832 ? 113.784 104.422 70.864  1.00 63.50 ? 832 ASP A O     1 
ATOM   5809 C  CB    . ASP A 1 832 ? 116.994 104.009 70.245  1.00 63.50 ? 832 ASP A CB    1 
ATOM   5810 C  CG    . ASP A 1 832 ? 118.338 104.653 70.504  1.00 63.50 ? 832 ASP A CG    1 
ATOM   5811 O  OD1   . ASP A 1 832 ? 118.414 105.549 71.370  1.00 63.50 ? 832 ASP A OD1   1 
ATOM   5812 O  OD2   . ASP A 1 832 ? 119.320 104.262 69.838  1.00 63.50 ? 832 ASP A OD2   1 
ATOM   5813 N  N     . LEU A 1 833 ? 114.448 102.281 71.043  1.00 61.80 ? 833 LEU A N     1 
ATOM   5814 C  CA    . LEU A 1 833 ? 113.119 101.790 70.693  1.00 61.80 ? 833 LEU A CA    1 
ATOM   5815 C  C     . LEU A 1 833 ? 112.116 102.023 71.819  1.00 61.80 ? 833 LEU A C     1 
ATOM   5816 O  O     . LEU A 1 833 ? 110.932 102.251 71.550  1.00 61.80 ? 833 LEU A O     1 
ATOM   5817 C  CB    . LEU A 1 833 ? 113.183 100.310 70.312  1.00 61.80 ? 833 LEU A CB    1 
ATOM   5818 C  CG    . LEU A 1 833 ? 111.859 99.692  69.859  1.00 61.80 ? 833 LEU A CG    1 
ATOM   5819 C  CD1   . LEU A 1 833 ? 111.358 100.371 68.605  1.00 61.80 ? 833 LEU A CD1   1 
ATOM   5820 C  CD2   . LEU A 1 833 ? 112.018 98.210  69.604  1.00 61.80 ? 833 LEU A CD2   1 
ATOM   5821 N  N     . HIS A 1 834 ? 112.561 101.979 73.077  1.00 58.13 ? 834 HIS A N     1 
ATOM   5822 C  CA    . HIS A 1 834 ? 111.687 102.371 74.178  1.00 58.13 ? 834 HIS A CA    1 
ATOM   5823 C  C     . HIS A 1 834 ? 111.255 103.822 74.038  1.00 58.13 ? 834 HIS A C     1 
ATOM   5824 O  O     . HIS A 1 834 ? 110.073 104.156 74.207  1.00 58.13 ? 834 HIS A O     1 
ATOM   5825 C  CB    . HIS A 1 834 ? 112.390 102.172 75.517  1.00 58.13 ? 834 HIS A CB    1 
ATOM   5826 C  CG    . HIS A 1 834 ? 111.537 102.519 76.698  1.00 58.13 ? 834 HIS A CG    1 
ATOM   5827 N  ND1   . HIS A 1 834 ? 112.056 103.001 77.879  1.00 58.13 ? 834 HIS A ND1   1 
ATOM   5828 C  CD2   . HIS A 1 834 ? 110.198 102.446 76.881  1.00 58.13 ? 834 HIS A CD2   1 
ATOM   5829 C  CE1   . HIS A 1 834 ? 111.076 103.214 78.737  1.00 58.13 ? 834 HIS A CE1   1 
ATOM   5830 N  NE2   . HIS A 1 834 ? 109.938 102.884 78.157  1.00 58.13 ? 834 HIS A NE2   1 
ATOM   5831 N  N     . ASN A 1 835 ? 112.211 104.707 73.744  1.00 61.14 ? 835 ASN A N     1 
ATOM   5832 C  CA    . ASN A 1 835 ? 111.854 106.102 73.520  1.00 61.14 ? 835 ASN A CA    1 
ATOM   5833 C  C     . ASN A 1 835 ? 110.922 106.237 72.326  1.00 61.14 ? 835 ASN A C     1 
ATOM   5834 O  O     . ASN A 1 835 ? 110.012 107.069 72.335  1.00 61.14 ? 835 ASN A O     1 
ATOM   5835 C  CB    . ASN A 1 835 ? 113.108 106.949 73.326  1.00 61.14 ? 835 ASN A CB    1 
ATOM   5836 C  CG    . ASN A 1 835 ? 113.668 107.457 74.634  1.00 61.14 ? 835 ASN A CG    1 
ATOM   5837 O  OD1   . ASN A 1 835 ? 114.742 107.046 75.062  1.00 61.14 ? 835 ASN A OD1   1 
ATOM   5838 N  ND2   . ASN A 1 835 ? 112.934 108.352 75.283  1.00 61.14 ? 835 ASN A ND2   1 
ATOM   5839 N  N     . ARG A 1 836 ? 111.129 105.419 71.293  1.00 60.10 ? 836 ARG A N     1 
ATOM   5840 C  CA    . ARG A 1 836 ? 110.245 105.453 70.133  1.00 60.10 ? 836 ARG A CA    1 
ATOM   5841 C  C     . ARG A 1 836 ? 108.822 105.059 70.508  1.00 60.10 ? 836 ARG A C     1 
ATOM   5842 O  O     . ARG A 1 836 ? 107.862 105.699 70.071  1.00 60.10 ? 836 ARG A O     1 
ATOM   5843 C  CB    . ARG A 1 836 ? 110.785 104.535 69.037  1.00 60.10 ? 836 ARG A CB    1 
ATOM   5844 C  CG    . ARG A 1 836 ? 110.111 104.719 67.689  1.00 60.10 ? 836 ARG A CG    1 
ATOM   5845 C  CD    . ARG A 1 836 ? 110.969 104.158 66.573  1.00 60.10 ? 836 ARG A CD    1 
ATOM   5846 N  NE    . ARG A 1 836 ? 112.289 104.775 66.555  1.00 60.10 ? 836 ARG A NE    1 
ATOM   5847 C  CZ    . ARG A 1 836 ? 113.427 104.111 66.698  1.00 60.10 ? 836 ARG A CZ    1 
ATOM   5848 N  NH1   . ARG A 1 836 ? 113.446 102.798 66.851  1.00 60.10 ? 836 ARG A NH1   1 
ATOM   5849 N  NH2   . ARG A 1 836 ? 114.575 104.783 66.687  1.00 60.10 ? 836 ARG A NH2   1 
ATOM   5850 N  N     . MET A 1 837 ? 108.666 104.011 71.318  1.00 59.17 ? 837 MET A N     1 
ATOM   5851 C  CA    . MET A 1 837 ? 107.334 103.590 71.747  1.00 59.17 ? 837 MET A CA    1 
ATOM   5852 C  C     . MET A 1 837 ? 106.657 104.677 72.573  1.00 59.17 ? 837 MET A C     1 
ATOM   5853 O  O     . MET A 1 837 ? 105.495 105.034 72.329  1.00 59.17 ? 837 MET A O     1 
ATOM   5854 C  CB    . MET A 1 837 ? 107.423 102.291 72.549  1.00 59.17 ? 837 MET A CB    1 
ATOM   5855 C  CG    . MET A 1 837 ? 107.728 101.057 71.722  1.00 59.17 ? 837 MET A CG    1 
ATOM   5856 S  SD    . MET A 1 837 ? 108.591 99.795  72.675  1.00 59.17 ? 837 MET A SD    1 
ATOM   5857 C  CE    . MET A 1 837 ? 108.081 98.311  71.817  1.00 59.17 ? 837 MET A CE    1 
ATOM   5858 N  N     . LYS A 1 838 ? 107.378 105.218 73.559  1.00 57.85 ? 838 LYS A N     1 
ATOM   5859 C  CA    . LYS A 1 838 ? 106.793 106.251 74.407  1.00 57.85 ? 838 LYS A CA    1 
ATOM   5860 C  C     . LYS A 1 838 ? 106.435 107.492 73.598  1.00 57.85 ? 838 LYS A C     1 
ATOM   5861 O  O     . LYS A 1 838 ? 105.371 108.088 73.801  1.00 57.85 ? 838 LYS A O     1 
ATOM   5862 C  CB    . LYS A 1 838 ? 107.749 106.603 75.545  1.00 57.85 ? 838 LYS A CB    1 
ATOM   5863 C  CG    . LYS A 1 838 ? 107.874 105.525 76.605  1.00 57.85 ? 838 LYS A CG    1 
ATOM   5864 C  CD    . LYS A 1 838 ? 108.940 105.885 77.624  1.00 57.85 ? 838 LYS A CD    1 
ATOM   5865 C  CE    . LYS A 1 838 ? 108.388 106.765 78.728  1.00 57.85 ? 838 LYS A CE    1 
ATOM   5866 N  NZ    . LYS A 1 838 ? 108.186 106.005 79.989  1.00 57.85 ? 838 LYS A NZ    1 
ATOM   5867 N  N     . ASP A 1 839 ? 107.111 107.606 72.462  1.00 61.49 ? 839 ASP A N     1 
ATOM   5868 C  CA    . ASP A 1 839 ? 106.827 108.720 71.536  1.00 61.49 ? 839 ASP A CA    1 
ATOM   5869 C  C     . ASP A 1 839 ? 105.562 108.425 70.738  1.00 61.49 ? 839 ASP A C     1 
ATOM   5870 O  O     . ASP A 1 839 ? 104.676 109.305 70.700  1.00 61.49 ? 839 ASP A O     1 
ATOM   5871 C  CB    . ASP A 1 839 ? 108.062 109.063 70.737  1.00 61.49 ? 839 ASP A CB    1 
ATOM   5872 C  CG    . ASP A 1 839 ? 108.767 110.147 71.507  1.00 61.49 ? 839 ASP A CG    1 
ATOM   5873 O  OD1   . ASP A 1 839 ? 108.893 109.969 72.728  1.00 61.49 ? 839 ASP A OD1   1 
ATOM   5874 O  OD2   . ASP A 1 839 ? 109.106 111.174 70.897  1.00 61.49 ? 839 ASP A OD2   1 
ATOM   5875 N  N     . GLU A 1 840 ? 105.501 107.228 70.160  1.00 60.97 ? 840 GLU A N     1 
ATOM   5876 C  CA    . GLU A 1 840 ? 104.324 106.713 69.418  1.00 60.97 ? 840 GLU A CA    1 
ATOM   5877 C  C     . GLU A 1 840 ? 103.062 107.076 70.198  1.00 60.97 ? 840 GLU A C     1 
ATOM   5878 O  O     . GLU A 1 840 ? 102.252 107.815 69.670  1.00 60.97 ? 840 GLU A O     1 
ATOM   5879 C  CB    . GLU A 1 840 ? 104.367 105.187 69.470  1.00 60.97 ? 840 GLU A CB    1 
ATOM   5880 C  CG    . GLU A 1 840 ? 104.951 104.498 68.262  1.00 60.97 ? 840 GLU A CG    1 
ATOM   5881 C  CD    . GLU A 1 840 ? 104.262 103.179 67.956  1.00 60.97 ? 840 GLU A CD    1 
ATOM   5882 O  OE1   . GLU A 1 840 ? 104.875 102.106 68.151  1.00 60.97 ? 840 GLU A OE1   1 
ATOM   5883 O  OE2   . GLU A 1 840 ? 103.105 103.229 67.530  1.00 60.97 ? 840 GLU A OE2   1 
ATOM   5884 N  N     . ILE A 1 841 ? 102.986 106.606 71.446  1.00 59.12 ? 841 ILE A N     1 
ATOM   5885 C  CA    . ILE A 1 841 ? 101.855 106.806 72.384  1.00 59.12 ? 841 ILE A CA    1 
ATOM   5886 C  C     . ILE A 1 841 ? 101.660 108.287 72.597  1.00 59.12 ? 841 ILE A C     1 
ATOM   5887 O  O     . ILE A 1 841 ? 100.532 108.721 72.411  1.00 59.12 ? 841 ILE A O     1 
ATOM   5888 C  CB    . ILE A 1 841 ? 102.107 106.134 73.734  1.00 59.12 ? 841 ILE A CB    1 
ATOM   5889 C  CG1   . ILE A 1 841 ? 102.795 104.780 73.593  1.00 59.12 ? 841 ILE A CG1   1 
ATOM   5890 C  CG2   . ILE A 1 841 ? 100.796 106.006 74.459  1.00 59.12 ? 841 ILE A CG2   1 
ATOM   5891 C  CD1   . ILE A 1 841 ? 102.517 103.845 74.725  1.00 59.12 ? 841 ILE A CD1   1 
ATOM   5892 N  N     . LYS A 1 842 ? 102.708 109.008 72.984  1.00 59.61 ? 842 LYS A N     1 
ATOM   5893 C  CA    . LYS A 1 842 ? 102.568 110.464 73.266  1.00 59.61 ? 842 LYS A CA    1 
ATOM   5894 C  C     . LYS A 1 842 ? 101.879 111.184 72.111  1.00 59.61 ? 842 LYS A C     1 
ATOM   5895 O  O     . LYS A 1 842 ? 100.872 111.876 72.362  1.00 59.61 ? 842 LYS A O     1 
ATOM   5896 C  CB    . LYS A 1 842 ? 103.932 111.109 73.447  1.00 59.61 ? 842 LYS A CB    1 
ATOM   5897 C  CG    . LYS A 1 842 ? 103.890 112.618 73.537  1.00 59.61 ? 842 LYS A CG    1 
ATOM   5898 C  CD    . LYS A 1 842 ? 105.246 113.200 73.792  1.00 59.61 ? 842 LYS A CD    1 
ATOM   5899 C  CE    . LYS A 1 842 ? 105.177 114.587 74.381  1.00 59.61 ? 842 LYS A CE    1 
ATOM   5900 N  NZ    . LYS A 1 842 ? 104.412 114.597 75.646  1.00 59.61 ? 842 LYS A NZ    1 
ATOM   5901 N  N     . TYR A 1 843 ? 102.401 110.989 70.897  1.00 64.76 ? 843 TYR A N     1 
ATOM   5902 C  CA    . TYR A 1 843 ? 101.863 111.603 69.656  1.00 64.76 ? 843 TYR A CA    1 
ATOM   5903 C  C     . TYR A 1 843 ? 100.397 111.221 69.470  1.00 64.76 ? 843 TYR A C     1 
ATOM   5904 O  O     . TYR A 1 843 ? 99.542  112.063 69.158  1.00 64.76 ? 843 TYR A O     1 
ATOM   5905 C  CB    . TYR A 1 843 ? 102.622 111.056 68.446  1.00 64.76 ? 843 TYR A CB    1 
ATOM   5906 C  CG    . TYR A 1 843 ? 104.075 111.447 68.376  1.00 64.76 ? 843 TYR A CG    1 
ATOM   5907 C  CD1   . TYR A 1 843 ? 104.606 112.387 69.243  1.00 64.76 ? 843 TYR A CD1   1 
ATOM   5908 C  CD2   . TYR A 1 843 ? 104.920 110.883 67.437  1.00 64.76 ? 843 TYR A CD2   1 
ATOM   5909 C  CE1   . TYR A 1 843 ? 105.940 112.751 69.187  1.00 64.76 ? 843 TYR A CE1   1 
ATOM   5910 C  CE2   . TYR A 1 843 ? 106.257 111.232 67.370  1.00 64.76 ? 843 TYR A CE2   1 
ATOM   5911 C  CZ    . TYR A 1 843 ? 106.771 112.171 68.245  1.00 64.76 ? 843 TYR A CZ    1 
ATOM   5912 O  OH    . TYR A 1 843 ? 108.087 112.531 68.178  1.00 64.76 ? 843 TYR A OH    1 
ATOM   5913 N  N     . LEU A 1 844 ? 100.104 109.943 69.687  1.00 62.12 ? 844 LEU A N     1 
ATOM   5914 C  CA    . LEU A 1 844 ? 98.719  109.438 69.527  1.00 62.12 ? 844 LEU A CA    1 
ATOM   5915 C  C     . LEU A 1 844 ? 97.803  110.237 70.445  1.00 62.12 ? 844 LEU A C     1 
ATOM   5916 O  O     . LEU A 1 844 ? 96.721  110.612 69.997  1.00 62.12 ? 844 LEU A O     1 
ATOM   5917 C  CB    . LEU A 1 844 ? 98.693  107.956 69.895  1.00 62.12 ? 844 LEU A CB    1 
ATOM   5918 C  CG    . LEU A 1 844 ? 98.518  107.012 68.716  1.00 62.12 ? 844 LEU A CG    1 
ATOM   5919 C  CD1   . LEU A 1 844 ? 98.213  107.806 67.466  1.00 62.12 ? 844 LEU A CD1   1 
ATOM   5920 C  CD2   . LEU A 1 844 ? 99.753  106.153 68.521  1.00 62.12 ? 844 LEU A CD2   1 
ATOM   5921 N  N     . VAL A 1 845 ? 98.218  110.446 71.698  1.00 63.17 ? 845 VAL A N     1 
ATOM   5922 C  CA    . VAL A 1 845 ? 97.342  111.250 72.585  1.00 63.17 ? 845 VAL A CA    1 
ATOM   5923 C  C     . VAL A 1 845 ? 97.499  112.724 72.240  1.00 63.17 ? 845 VAL A C     1 
ATOM   5924 O  O     . VAL A 1 845 ? 96.642  113.460 72.668  1.00 63.17 ? 845 VAL A O     1 
ATOM   5925 C  CB    . VAL A 1 845 ? 97.487  110.951 74.088  1.00 63.17 ? 845 VAL A CB    1 
ATOM   5926 C  CG1   . VAL A 1 845 ? 98.873  110.513 74.483  1.00 63.17 ? 845 VAL A CG1   1 
ATOM   5927 C  CG2   . VAL A 1 845 ? 97.005  112.091 74.961  1.00 63.17 ? 845 VAL A CG2   1 
ATOM   5928 N  N     . GLU A 1 846 ? 98.499  113.158 71.473  1.00 67.60 ? 846 GLU A N     1 
ATOM   5929 C  CA    . GLU A 1 846 ? 98.405  114.634 71.247  1.00 67.60 ? 846 GLU A CA    1 
ATOM   5930 C  C     . GLU A 1 846 ? 97.454  115.015 70.107  1.00 67.60 ? 846 GLU A C     1 
ATOM   5931 O  O     . GLU A 1 846 ? 97.147  116.190 70.016  1.00 67.60 ? 846 GLU A O     1 
ATOM   5932 C  CB    . GLU A 1 846 ? 99.758  115.301 70.992  1.00 67.60 ? 846 GLU A CB    1 
ATOM   5933 C  CG    . GLU A 1 846 ? 100.777 115.120 72.102  1.00 67.60 ? 846 GLU A CG    1 
ATOM   5934 C  CD    . GLU A 1 846 ? 100.545 116.001 73.309  1.00 67.60 ? 846 GLU A CD    1 
ATOM   5935 O  OE1   . GLU A 1 846 ? 99.377  116.308 73.565  1.00 67.60 ? 846 GLU A OE1   1 
ATOM   5936 O  OE2   . GLU A 1 846 ? 101.524 116.363 73.985  1.00 67.60 ? 846 GLU A OE2   1 
ATOM   5937 N  N     . LYS A 1 847 ? 97.038  114.072 69.260  1.00 64.73 ? 847 LYS A N     1 
ATOM   5938 C  CA    . LYS A 1 847 ? 96.078  114.374 68.158  1.00 64.73 ? 847 LYS A CA    1 
ATOM   5939 C  C     . LYS A 1 847 ? 94.651  114.013 68.597  1.00 64.73 ? 847 LYS A C     1 
ATOM   5940 O  O     . LYS A 1 847 ? 93.840  113.760 67.704  1.00 64.73 ? 847 LYS A O     1 
ATOM   5941 C  CB    . LYS A 1 847 ? 96.402  113.596 66.874  1.00 64.73 ? 847 LYS A CB    1 
ATOM   5942 C  CG    . LYS A 1 847 ? 97.871  113.507 66.472  1.00 64.73 ? 847 LYS A CG    1 
ATOM   5943 C  CD    . LYS A 1 847 ? 98.476  112.100 66.542  1.00 64.73 ? 847 LYS A CD    1 
ATOM   5944 C  CE    . LYS A 1 847 ? 99.160  111.613 65.276  1.00 64.73 ? 847 LYS A CE    1 
ATOM   5945 N  NZ    . LYS A 1 847 ? 100.584 112.014 65.197  1.00 64.73 ? 847 LYS A NZ    1 
ATOM   5946 N  N     . GLU A 1 848 ? 94.405  113.934 69.912  1.00 67.32 ? 848 GLU A N     1 
ATOM   5947 C  CA    . GLU A 1 848 ? 93.099  113.636 70.563  1.00 67.32 ? 848 GLU A CA    1 
ATOM   5948 C  C     . GLU A 1 848 ? 92.559  112.242 70.199  1.00 67.32 ? 848 GLU A C     1 
ATOM   5949 O  O     . GLU A 1 848 ? 91.333  112.087 70.306  1.00 67.32 ? 848 GLU A O     1 
ATOM   5950 C  CB    . GLU A 1 848 ? 92.056  114.703 70.190  1.00 67.32 ? 848 GLU A CB    1 
ATOM   5951 C  CG    . GLU A 1 848 ? 91.868  115.836 71.199  1.00 67.32 ? 848 GLU A CG    1 
ATOM   5952 C  CD    . GLU A 1 848 ? 90.654  115.750 72.120  1.00 67.32 ? 848 GLU A CD    1 
ATOM   5953 O  OE1   . GLU A 1 848 ? 89.554  115.451 71.626  1.00 67.32 ? 848 GLU A OE1   1 
ATOM   5954 O  OE2   . GLU A 1 848 ? 90.808  115.979 73.334  1.00 67.32 ? 848 GLU A OE2   1 
ATOM   5955 N  N     . VAL A 1 849 ? 93.388  111.263 69.823  1.00 67.08 ? 849 VAL A N     1 
ATOM   5956 C  CA    . VAL A 1 849 ? 92.842  109.927 69.417  1.00 67.08 ? 849 VAL A CA    1 
ATOM   5957 C  C     . VAL A 1 849 ? 91.972  109.359 70.540  1.00 67.08 ? 849 VAL A C     1 
ATOM   5958 O  O     . VAL A 1 849 ? 92.429  109.386 71.681  1.00 67.08 ? 849 VAL A O     1 
ATOM   5959 C  CB    . VAL A 1 849 ? 93.941  108.912 69.058  1.00 67.08 ? 849 VAL A CB    1 
ATOM   5960 C  CG1   . VAL A 1 849 ? 93.345  107.562 68.708  1.00 67.08 ? 849 VAL A CG1   1 
ATOM   5961 C  CG2   . VAL A 1 849 ? 94.820  109.380 67.924  1.00 67.08 ? 849 VAL A CG2   1 
ATOM   5962 N  N     . LEU A 1 850 ? 90.779  108.845 70.225  1.00 68.08 ? 850 LEU A N     1 
ATOM   5963 C  CA    . LEU A 1 850 ? 89.848  108.310 71.268  1.00 68.08 ? 850 LEU A CA    1 
ATOM   5964 C  C     . LEU A 1 850 ? 90.343  107.020 71.941  1.00 68.08 ? 850 LEU A C     1 
ATOM   5965 O  O     . LEU A 1 850 ? 90.345  105.954 71.325  1.00 68.08 ? 850 LEU A O     1 
ATOM   5966 C  CB    . LEU A 1 850 ? 88.433  108.147 70.701  1.00 68.08 ? 850 LEU A CB    1 
ATOM   5967 C  CG    . LEU A 1 850 ? 87.325  108.386 71.721  1.00 68.08 ? 850 LEU A CG    1 
ATOM   5968 C  CD1   . LEU A 1 850 ? 86.868  109.833 71.715  1.00 68.08 ? 850 LEU A CD1   1 
ATOM   5969 C  CD2   . LEU A 1 850 ? 86.163  107.454 71.483  1.00 68.08 ? 850 LEU A CD2   1 
ATOM   5970 N  N     . ALA A 1 851 ? 90.609  107.106 73.233  1.00 63.74 ? 851 ALA A N     1 
ATOM   5971 C  CA    . ALA A 1 851 ? 91.088  105.944 73.999  1.00 63.74 ? 851 ALA A CA    1 
ATOM   5972 C  C     . ALA A 1 851 ? 89.904  105.104 74.461  1.00 63.74 ? 851 ALA A C     1 
ATOM   5973 O  O     . ALA A 1 851 ? 88.767  105.537 74.303  1.00 63.74 ? 851 ALA A O     1 
ATOM   5974 C  CB    . ALA A 1 851 ? 91.814  106.471 75.199  1.00 63.74 ? 851 ALA A CB    1 
ATOM   5975 N  N     . ARG A 1 852 ? 90.180  103.940 75.032  1.00 59.27 ? 852 ARG A N     1 
ATOM   5976 C  CA    . ARG A 1 852 ? 89.101  103.126 75.629  1.00 59.27 ? 852 ARG A CA    1 
ATOM   5977 C  C     . ARG A 1 852 ? 89.300  103.137 77.143  1.00 59.27 ? 852 ARG A C     1 
ATOM   5978 O  O     . ARG A 1 852 ? 90.405  103.448 77.581  1.00 59.27 ? 852 ARG A O     1 
ATOM   5979 C  CB    . ARG A 1 852 ? 89.258  101.681 75.181  1.00 59.27 ? 852 ARG A CB    1 
ATOM   5980 C  CG    . ARG A 1 852 ? 87.969  100.882 75.178  1.00 59.27 ? 852 ARG A CG    1 
ATOM   5981 C  CD    . ARG A 1 852 ? 87.916  100.148 73.865  1.00 59.27 ? 852 ARG A CD    1 
ATOM   5982 N  NE    . ARG A 1 852 ? 88.875  99.076  73.891  1.00 59.27 ? 852 ARG A NE    1 
ATOM   5983 C  CZ    . ARG A 1 852 ? 88.720  98.025  74.652  1.00 59.27 ? 852 ARG A CZ    1 
ATOM   5984 N  NH1   . ARG A 1 852 ? 87.940  98.109  75.708  1.00 59.27 ? 852 ARG A NH1   1 
ATOM   5985 N  NH2   . ARG A 1 852 ? 89.316  96.894  74.351  1.00 59.27 ? 852 ARG A NH2   1 
ATOM   5986 N  N     . ARG A 1 853 ? 88.254  102.870 77.923  1.00 56.22 ? 853 ARG A N     1 
ATOM   5987 C  CA    . ARG A 1 853 ? 88.443  102.782 79.393  1.00 56.22 ? 853 ARG A CA    1 
ATOM   5988 C  C     . ARG A 1 853 ? 88.387  101.302 79.759  1.00 56.22 ? 853 ARG A C     1 
ATOM   5989 O  O     . ARG A 1 853 ? 87.393  100.652 79.501  1.00 56.22 ? 853 ARG A O     1 
ATOM   5990 C  CB    . ARG A 1 853 ? 87.486  103.675 80.182  1.00 56.22 ? 853 ARG A CB    1 
ATOM   5991 C  CG    . ARG A 1 853 ? 87.986  105.102 80.356  1.00 56.22 ? 853 ARG A CG    1 
ATOM   5992 C  CD    . ARG A 1 853 ? 88.452  105.514 81.738  1.00 56.22 ? 853 ARG A CD    1 
ATOM   5993 N  NE    . ARG A 1 853 ? 88.848  104.361 82.533  1.00 56.22 ? 853 ARG A NE    1 
ATOM   5994 C  CZ    . ARG A 1 853 ? 89.626  104.427 83.597  1.00 56.22 ? 853 ARG A CZ    1 
ATOM   5995 N  NH1   . ARG A 1 853 ? 90.362  105.500 83.811  1.00 56.22 ? 853 ARG A NH1   1 
ATOM   5996 N  NH2   . ARG A 1 853 ? 89.650  103.427 84.449  1.00 56.22 ? 853 ARG A NH2   1 
ATOM   5997 N  N     . VAL A 1 854 ? 89.450  100.810 80.345  1.00 52.26 ? 854 VAL A N     1 
ATOM   5998 C  CA    . VAL A 1 854 ? 89.653  99.409  80.688  1.00 52.26 ? 854 VAL A CA    1 
ATOM   5999 C  C     . VAL A 1 854 ? 89.700  99.293  82.203  1.00 52.26 ? 854 VAL A C     1 
ATOM   6000 O  O     . VAL A 1 854 ? 90.406  100.061 82.866  1.00 52.26 ? 854 VAL A O     1 
ATOM   6001 C  CB    . VAL A 1 854 ? 90.939  98.848  80.056  1.00 52.26 ? 854 VAL A CB    1 
ATOM   6002 C  CG1   . VAL A 1 854 ? 91.243  97.473  80.613  1.00 52.26 ? 854 VAL A CG1   1 
ATOM   6003 C  CG2   . VAL A 1 854 ? 90.798  98.794  78.548  1.00 52.26 ? 854 VAL A CG2   1 
ATOM   6004 N  N     . SER A 1 855 ? 88.950  98.342  82.749  1.00 50.20 ? 855 SER A N     1 
ATOM   6005 C  CA    . SER A 1 855 ? 88.860  98.128  84.187  1.00 50.20 ? 855 SER A CA    1 
ATOM   6006 C  C     . SER A 1 855 ? 89.618  96.862  84.554  1.00 50.20 ? 855 SER A C     1 
ATOM   6007 O  O     . SER A 1 855 ? 89.549  95.862  83.832  1.00 50.20 ? 855 SER A O     1 
ATOM   6008 C  CB    . SER A 1 855 ? 87.402  98.018  84.633  1.00 50.20 ? 855 SER A CB    1 
ATOM   6009 O  OG    . SER A 1 855 ? 86.910  96.706  84.425  1.00 50.20 ? 855 SER A OG    1 
ATOM   6010 N  N     . LEU A 1 856 ? 90.341  96.905  85.672  1.00 44.42 ? 856 LEU A N     1 
ATOM   6011 C  CA    . LEU A 1 856 ? 91.146  95.764  86.084  1.00 44.42 ? 856 LEU A CA    1 
ATOM   6012 C  C     . LEU A 1 856 ? 90.329  94.702  86.806  1.00 44.42 ? 856 LEU A C     1 
ATOM   6013 O  O     . LEU A 1 856 ? 90.774  93.553  86.895  1.00 44.42 ? 856 LEU A O     1 
ATOM   6014 C  CB    . LEU A 1 856 ? 92.280  96.209  87.008  1.00 44.42 ? 856 LEU A CB    1 
ATOM   6015 C  CG    . LEU A 1 856 ? 93.549  96.811  86.405  1.00 44.42 ? 856 LEU A CG    1 
ATOM   6016 C  CD1   . LEU A 1 856 ? 94.274  95.830  85.495  1.00 44.42 ? 856 LEU A CD1   1 
ATOM   6017 C  CD2   . LEU A 1 856 ? 93.248  98.130  85.724  1.00 44.42 ? 856 LEU A CD2   1 
ATOM   6018 N  N     . SER A 1 857 ? 89.156  95.062  87.323  1.00 50.31 ? 857 SER A N     1 
ATOM   6019 C  CA    . SER A 1 857 ? 88.336  94.163  88.123  1.00 50.31 ? 857 SER A CA    1 
ATOM   6020 C  C     . SER A 1 857 ? 87.369  93.337  87.290  1.00 50.31 ? 857 SER A C     1 
ATOM   6021 O  O     . SER A 1 857 ? 86.638  92.518  87.856  1.00 50.31 ? 857 SER A O     1 
ATOM   6022 C  CB    . SER A 1 857 ? 87.558  94.962  89.171  1.00 50.31 ? 857 SER A CB    1 
ATOM   6023 O  OG    . SER A 1 857 ? 86.691  95.896  88.554  1.00 50.31 ? 857 SER A OG    1 
ATOM   6024 N  N     . ASP A 1 858 ? 87.338  93.537  85.976  1.00 55.00 ? 858 ASP A N     1 
ATOM   6025 C  CA    . ASP A 1 858 ? 86.471  92.750  85.114  1.00 55.00 ? 858 ASP A CA    1 
ATOM   6026 C  C     . ASP A 1 858 ? 86.839  91.274  85.211  1.00 55.00 ? 858 ASP A C     1 
ATOM   6027 O  O     . ASP A 1 858 ? 88.012  90.908  85.322  1.00 55.00 ? 858 ASP A O     1 
ATOM   6028 C  CB    . ASP A 1 858 ? 86.583  93.235  83.668  1.00 55.00 ? 858 ASP A CB    1 
ATOM   6029 C  CG    . ASP A 1 858 ? 85.491  92.677  82.771  1.00 55.00 ? 858 ASP A CG    1 
ATOM   6030 O  OD1   . ASP A 1 858 ? 85.029  91.541  83.005  1.00 55.00 ? 858 ASP A OD1   1 
ATOM   6031 O  OD2   . ASP A 1 858 ? 85.096  93.382  81.820  1.00 55.00 ? 858 ASP A OD2   1 
ATOM   6032 N  N     . SER A 1 859 ? 85.817  90.424  85.181  1.00 56.74 ? 859 SER A N     1 
ATOM   6033 C  CA    . SER A 1 859 ? 86.009  88.985  85.292  1.00 56.74 ? 859 SER A CA    1 
ATOM   6034 C  C     . SER A 1 859 ? 86.151  88.301  83.940  1.00 56.74 ? 859 SER A C     1 
ATOM   6035 O  O     . SER A 1 859 ? 86.322  87.079  83.895  1.00 56.74 ? 859 SER A O     1 
ATOM   6036 C  CB    . SER A 1 859 ? 84.850  88.357  86.071  1.00 56.74 ? 859 SER A CB    1 
ATOM   6037 O  OG    . SER A 1 859 ? 85.024  86.957  86.200  1.00 56.74 ? 859 SER A OG    1 
ATOM   6038 N  N     . THR A 1 860 ? 86.086  89.051  82.844  1.00 54.07 ? 860 THR A N     1 
ATOM   6039 C  CA    . THR A 1 860 ? 86.290  88.500  81.513  1.00 54.07 ? 860 THR A CA    1 
ATOM   6040 C  C     . THR A 1 860 ? 87.749  88.530  81.082  1.00 54.07 ? 860 THR A C     1 
ATOM   6041 O  O     . THR A 1 860 ? 88.052  88.154  79.945  1.00 54.07 ? 860 THR A O     1 
ATOM   6042 C  CB    . THR A 1 860 ? 85.442  89.254  80.486  1.00 54.07 ? 860 THR A CB    1 
ATOM   6043 O  OG1   . THR A 1 860 ? 85.931  90.593  80.352  1.00 54.07 ? 860 THR A OG1   1 
ATOM   6044 C  CG2   . THR A 1 860 ? 83.987  89.289  80.924  1.00 54.07 ? 860 THR A CG2   1 
ATOM   6045 N  N     . ILE A 1 861 ? 88.654  88.975  81.952  1.00 47.93 ? 861 ILE A N     1 
ATOM   6046 C  CA    . ILE A 1 861 ? 90.071  88.998  81.618  1.00 47.93 ? 861 ILE A CA    1 
ATOM   6047 C  C     . ILE A 1 861 ? 90.608  87.574  81.605  1.00 47.93 ? 861 ILE A C     1 
ATOM   6048 O  O     . ILE A 1 861 ? 90.439  86.820  82.571  1.00 47.93 ? 861 ILE A O     1 
ATOM   6049 C  CB    . ILE A 1 861 ? 90.842  89.876  82.614  1.00 47.93 ? 861 ILE A CB    1 
ATOM   6050 C  CG1   . ILE A 1 861 ? 90.373  91.328  82.519  1.00 47.93 ? 861 ILE A CG1   1 
ATOM   6051 C  CG2   . ILE A 1 861 ? 92.338  89.761  82.382  1.00 47.93 ? 861 ILE A CG2   1 
ATOM   6052 C  CD1   . ILE A 1 861 ? 90.725  91.998  81.215  1.00 47.93 ? 861 ILE A CD1   1 
ATOM   6053 N  N     . LYS A 1 862 ? 91.254  87.194  80.502  1.00 44.07 ? 862 LYS A N     1 
ATOM   6054 C  CA    . LYS A 1 862 ? 91.811  85.849  80.414  1.00 44.07 ? 862 LYS A CA    1 
ATOM   6055 C  C     . LYS A 1 862 ? 93.070  85.708  81.257  1.00 44.07 ? 862 LYS A C     1 
ATOM   6056 O  O     . LYS A 1 862 ? 93.254  84.693  81.938  1.00 44.07 ? 862 LYS A O     1 
ATOM   6057 C  CB    . LYS A 1 862 ? 92.099  85.488  78.958  1.00 44.07 ? 862 LYS A CB    1 
ATOM   6058 C  CG    . LYS A 1 862 ? 92.245  83.994  78.719  1.00 44.07 ? 862 LYS A CG    1 
ATOM   6059 C  CD    . LYS A 1 862 ? 90.982  83.245  79.104  1.00 44.07 ? 862 LYS A CD    1 
ATOM   6060 C  CE    . LYS A 1 862 ? 91.285  81.794  79.440  1.00 44.07 ? 862 LYS A CE    1 
ATOM   6061 N  NZ    . LYS A 1 862 ? 90.295  81.229  80.399  1.00 44.07 ? 862 LYS A NZ    1 
ATOM   6062 N  N     . SER A 1 863 ? 93.951  86.705  81.225  1.00 41.18 ? 863 SER A N     1 
ATOM   6063 C  CA    . SER A 1 863 ? 95.203  86.618  81.965  1.00 41.18 ? 863 SER A CA    1 
ATOM   6064 C  C     . SER A 1 863 ? 95.761  88.015  82.191  1.00 41.18 ? 863 SER A C     1 
ATOM   6065 O  O     . SER A 1 863 ? 95.384  88.978  81.520  1.00 41.18 ? 863 SER A O     1 
ATOM   6066 C  CB    . SER A 1 863 ? 96.224  85.745  81.230  1.00 41.18 ? 863 SER A CB    1 
ATOM   6067 O  OG    . SER A 1 863 ? 95.843  84.382  81.260  1.00 41.18 ? 863 SER A OG    1 
ATOM   6068 N  N     . TYR A 1 864 ? 96.668  88.107  83.161  1.00 38.55 ? 864 TYR A N     1 
ATOM   6069 C  CA    . TYR A 1 864 ? 97.497  89.282  83.383  1.00 38.55 ? 864 TYR A CA    1 
ATOM   6070 C  C     . TYR A 1 864 ? 98.935  88.903  83.064  1.00 38.55 ? 864 TYR A C     1 
ATOM   6071 O  O     . TYR A 1 864 ? 99.466  87.946  83.635  1.00 38.55 ? 864 TYR A O     1 
ATOM   6072 C  CB    . TYR A 1 864 ? 97.385  89.787  84.826  1.00 38.55 ? 864 TYR A CB    1 
ATOM   6073 C  CG    . TYR A 1 864 ? 96.037  90.372  85.186  1.00 38.55 ? 864 TYR A CG    1 
ATOM   6074 C  CD1   . TYR A 1 864 ? 95.759  91.710  84.957  1.00 38.55 ? 864 TYR A CD1   1 
ATOM   6075 C  CD2   . TYR A 1 864 ? 95.049  89.590  85.762  1.00 38.55 ? 864 TYR A CD2   1 
ATOM   6076 C  CE1   . TYR A 1 864 ? 94.533  92.250  85.285  1.00 38.55 ? 864 TYR A CE1   1 
ATOM   6077 C  CE2   . TYR A 1 864 ? 93.819  90.123  86.092  1.00 38.55 ? 864 TYR A CE2   1 
ATOM   6078 C  CZ    . TYR A 1 864 ? 93.567  91.453  85.852  1.00 38.55 ? 864 TYR A CZ    1 
ATOM   6079 O  OH    . TYR A 1 864 ? 92.345  91.990  86.180  1.00 38.55 ? 864 TYR A OH    1 
ATOM   6080 N  N     . LYS A 1 865 ? 99.563  89.650  82.155  1.00 35.73 ? 865 LYS A N     1 
ATOM   6081 C  CA    . LYS A 1 865 ? 100.872 89.281  81.638  1.00 35.73 ? 865 LYS A CA    1 
ATOM   6082 C  C     . LYS A 1 865 ? 102.002 90.201  82.074  1.00 35.73 ? 865 LYS A C     1 
ATOM   6083 O  O     . LYS A 1 865 ? 103.161 89.906  81.764  1.00 35.73 ? 865 LYS A O     1 
ATOM   6084 C  CB    . LYS A 1 865 ? 100.837 89.224  80.104  1.00 35.73 ? 865 LYS A CB    1 
ATOM   6085 C  CG    . LYS A 1 865 ? 100.038 88.057  79.554  1.00 35.73 ? 865 LYS A CG    1 
ATOM   6086 C  CD    . LYS A 1 865 ? 100.104 88.002  78.040  1.00 35.73 ? 865 LYS A CD    1 
ATOM   6087 C  CE    . LYS A 1 865 ? 99.248  89.083  77.409  1.00 35.73 ? 865 LYS A CE    1 
ATOM   6088 N  NZ    . LYS A 1 865 ? 97.799  88.849  77.647  1.00 35.73 ? 865 LYS A NZ    1 
ATOM   6089 N  N     . SER A 1 866 ? 101.712 91.295  82.774  1.00 34.40 ? 866 SER A N     1 
ATOM   6090 C  CA    . SER A 1 866 ? 102.777 92.178  83.231  1.00 34.40 ? 866 SER A CA    1 
ATOM   6091 C  C     . SER A 1 866 ? 103.693 91.455  84.203  1.00 34.40 ? 866 SER A C     1 
ATOM   6092 O  O     . SER A 1 866 ? 103.232 90.752  85.104  1.00 34.40 ? 866 SER A O     1 
ATOM   6093 C  CB    . SER A 1 866 ? 102.201 93.426  83.889  1.00 34.40 ? 866 SER A CB    1 
ATOM   6094 O  OG    . SER A 1 866 ? 101.756 94.337  82.911  1.00 34.40 ? 866 SER A OG    1 
ATOM   6095 N  N     . PHE A 1 867 ? 104.997 91.635  84.008  1.00 32.51 ? 867 PHE A N     1 
ATOM   6096 C  CA    . PHE A 1 867 ? 106.014 91.011  84.848  1.00 32.51 ? 867 PHE A CA    1 
ATOM   6097 C  C     . PHE A 1 867 ? 105.818 89.500  84.906  1.00 32.51 ? 867 PHE A C     1 
ATOM   6098 O  O     . PHE A 1 867 ? 106.008 88.865  85.944  1.00 32.51 ? 867 PHE A O     1 
ATOM   6099 C  CB    . PHE A 1 867 ? 106.023 91.627  86.247  1.00 32.51 ? 867 PHE A CB    1 
ATOM   6100 C  CG    . PHE A 1 867 ? 106.242 93.110  86.245  1.00 32.51 ? 867 PHE A CG    1 
ATOM   6101 C  CD1   . PHE A 1 867 ? 105.172 93.982  86.215  1.00 32.51 ? 867 PHE A CD1   1 
ATOM   6102 C  CD2   . PHE A 1 867 ? 107.520 93.632  86.244  1.00 32.51 ? 867 PHE A CD2   1 
ATOM   6103 C  CE1   . PHE A 1 867 ? 105.374 95.345  86.203  1.00 32.51 ? 867 PHE A CE1   1 
ATOM   6104 C  CE2   . PHE A 1 867 ? 107.724 94.995  86.229  1.00 32.51 ? 867 PHE A CE2   1 
ATOM   6105 C  CZ    . PHE A 1 867 ? 106.650 95.850  86.210  1.00 32.51 ? 867 PHE A CZ    1 
ATOM   6106 N  N     . ALA A 1 868 ? 105.427 88.923  83.773  1.00 35.44 ? 868 ALA A N     1 
ATOM   6107 C  CA    . ALA A 1 868 ? 105.241 87.483  83.630  1.00 35.44 ? 868 ALA A CA    1 
ATOM   6108 C  C     . ALA A 1 868 ? 106.123 87.005  82.485  1.00 35.44 ? 868 ALA A C     1 
ATOM   6109 O  O     . ALA A 1 868 ? 105.879 87.342  81.322  1.00 35.44 ? 868 ALA A O     1 
ATOM   6110 C  CB    . ALA A 1 868 ? 103.774 87.135  83.380  1.00 35.44 ? 868 ALA A CB    1 
ATOM   6111 N  N     . HIS A 1 869 ? 107.152 86.231  82.820  1.00 41.06 ? 869 HIS A N     1 
ATOM   6112 C  CA    . HIS A 1 869 ? 108.106 85.717  81.849  1.00 41.06 ? 869 HIS A CA    1 
ATOM   6113 C  C     . HIS A 1 869 ? 107.926 84.232  81.564  1.00 41.06 ? 869 HIS A C     1 
ATOM   6114 O  O     . HIS A 1 869 ? 108.638 83.689  80.714  1.00 41.06 ? 869 HIS A O     1 
ATOM   6115 C  CB    . HIS A 1 869 ? 109.531 85.973  82.340  1.00 41.06 ? 869 HIS A CB    1 
ATOM   6116 C  CG    . HIS A 1 869 ? 109.853 85.277  83.623  1.00 41.06 ? 869 HIS A CG    1 
ATOM   6117 N  ND1   . HIS A 1 869 ? 110.724 84.211  83.692  1.00 41.06 ? 869 HIS A ND1   1 
ATOM   6118 C  CD2   . HIS A 1 869 ? 109.412 85.485  84.885  1.00 41.06 ? 869 HIS A CD2   1 
ATOM   6119 C  CE1   . HIS A 1 869 ? 110.807 83.795  84.943  1.00 41.06 ? 869 HIS A CE1   1 
ATOM   6120 N  NE2   . HIS A 1 869 ? 110.021 84.551  85.686  1.00 41.06 ? 869 HIS A NE2   1 
ATOM   6121 N  N     . VAL A 1 870 ? 107.003 83.564  82.247  1.00 40.23 ? 870 VAL A N     1 
ATOM   6122 C  CA    . VAL A 1 870 ? 106.774 82.143  82.028  1.00 40.23 ? 870 VAL A CA    1 
ATOM   6123 C  C     . VAL A 1 870 ? 105.542 81.935  81.158  1.00 40.23 ? 870 VAL A C     1 
ATOM   6124 O  O     . VAL A 1 870 ? 105.591 81.226  80.153  1.00 40.23 ? 870 VAL A O     1 
ATOM   6125 C  CB    . VAL A 1 870 ? 106.631 81.391  83.355  1.00 40.23 ? 870 VAL A CB    1 
ATOM   6126 C  CG1   . VAL A 1 870 ? 106.166 79.967  83.105  1.00 40.23 ? 870 VAL A CG1   1 
ATOM   6127 C  CG2   . VAL A 1 870 ? 107.946 81.397  84.110  1.00 40.23 ? 870 VAL A CG2   1 
ATOM   6128 P  P     . G   B 2 1   ? 94.495  108.531 134.141 1.00 31.43 ? -35 G   B P     1 
ATOM   6129 O  OP1   . G   B 2 1   ? 93.451  108.069 135.090 1.00 31.43 ? -35 G   B OP1   1 
ATOM   6130 O  OP2   . G   B 2 1   ? 94.683  109.982 133.904 1.00 31.43 ? -35 G   B OP2   1 
ATOM   6131 O  "O5'" . G   B 2 1   ? 95.895  107.921 134.595 1.00 31.43 ? -35 G   B "O5'" 1 
ATOM   6132 C  "C5'" . G   B 2 1   ? 97.104  108.625 134.361 1.00 31.43 ? -35 G   B "C5'" 1 
ATOM   6133 C  "C4'" . G   B 2 1   ? 98.176  107.721 133.810 1.00 31.43 ? -35 G   B "C4'" 1 
ATOM   6134 O  "O4'" . G   B 2 1   ? 97.591  106.462 133.398 1.00 31.43 ? -35 G   B "O4'" 1 
ATOM   6135 C  "C3'" . G   B 2 1   ? 98.887  108.229 132.566 1.00 31.43 ? -35 G   B "C3'" 1 
ATOM   6136 O  "O3'" . G   B 2 1   ? 99.925  109.145 132.862 1.00 31.43 ? -35 G   B "O3'" 1 
ATOM   6137 C  "C2'" . G   B 2 1   ? 99.374  106.946 131.905 1.00 31.43 ? -35 G   B "C2'" 1 
ATOM   6138 O  "O2'" . G   B 2 1   ? 100.559 106.474 132.527 1.00 31.43 ? -35 G   B "O2'" 1 
ATOM   6139 C  "C1'" . G   B 2 1   ? 98.237  105.983 132.238 1.00 31.43 ? -35 G   B "C1'" 1 
ATOM   6140 N  N9    . G   B 2 1   ? 97.238  105.884 131.156 1.00 31.43 ? -35 G   B N9    1 
ATOM   6141 C  C8    . G   B 2 1   ? 95.890  106.094 131.284 1.00 31.43 ? -35 G   B C8    1 
ATOM   6142 N  N7    . G   B 2 1   ? 95.234  105.927 130.176 1.00 31.43 ? -35 G   B N7    1 
ATOM   6143 C  C5    . G   B 2 1   ? 96.204  105.574 129.255 1.00 31.43 ? -35 G   B C5    1 
ATOM   6144 C  C6    . G   B 2 1   ? 96.086  105.267 127.878 1.00 31.43 ? -35 G   B C6    1 
ATOM   6145 O  O6    . G   B 2 1   ? 95.070  105.245 127.177 1.00 31.43 ? -35 G   B O6    1 
ATOM   6146 N  N1    . G   B 2 1   ? 97.317  104.963 127.317 1.00 31.43 ? -35 G   B N1    1 
ATOM   6147 C  C2    . G   B 2 1   ? 98.506  104.955 127.990 1.00 31.43 ? -35 G   B C2    1 
ATOM   6148 N  N2    . G   B 2 1   ? 99.589  104.635 127.274 1.00 31.43 ? -35 G   B N2    1 
ATOM   6149 N  N3    . G   B 2 1   ? 98.629  105.235 129.271 1.00 31.43 ? -35 G   B N3    1 
ATOM   6150 C  C4    . G   B 2 1   ? 97.446  105.536 129.842 1.00 31.43 ? -35 G   B C4    1 
ATOM   6151 P  P     . U   B 2 2   ? 99.916  110.614 132.217 1.00 35.85 ? -34 U   B P     1 
ATOM   6152 O  OP1   . U   B 2 2   ? 100.756 111.486 133.069 1.00 35.85 ? -34 U   B OP1   1 
ATOM   6153 O  OP2   . U   B 2 2   ? 98.512  110.997 131.939 1.00 35.85 ? -34 U   B OP2   1 
ATOM   6154 O  "O5'" . U   B 2 2   ? 100.666 110.427 130.827 1.00 35.85 ? -34 U   B "O5'" 1 
ATOM   6155 C  "C5'" . U   B 2 2   ? 102.036 110.063 130.784 1.00 35.85 ? -34 U   B "C5'" 1 
ATOM   6156 C  "C4'" . U   B 2 2   ? 102.462 109.683 129.389 1.00 35.85 ? -34 U   B "C4'" 1 
ATOM   6157 O  "O4'" . U   B 2 2   ? 101.733 108.505 128.960 1.00 35.85 ? -34 U   B "O4'" 1 
ATOM   6158 C  "C3'" . U   B 2 2   ? 102.169 110.702 128.301 1.00 35.85 ? -34 U   B "C3'" 1 
ATOM   6159 O  "O3'" . U   B 2 2   ? 103.102 111.765 128.251 1.00 35.85 ? -34 U   B "O3'" 1 
ATOM   6160 C  "C2'" . U   B 2 2   ? 102.150 109.839 127.050 1.00 35.85 ? -34 U   B "C2'" 1 
ATOM   6161 O  "O2'" . U   B 2 2   ? 103.470 109.488 126.668 1.00 35.85 ? -34 U   B "O2'" 1 
ATOM   6162 C  "C1'" . U   B 2 2   ? 101.462 108.585 127.576 1.00 35.85 ? -34 U   B "C1'" 1 
ATOM   6163 N  N1    . U   B 2 2   ? 99.995  108.635 127.380 1.00 35.85 ? -34 U   B N1    1 
ATOM   6164 C  C2    . U   B 2 2   ? 99.509  108.292 126.140 1.00 35.85 ? -34 U   B C2    1 
ATOM   6165 O  O2    . U   B 2 2   ? 100.226 107.955 125.217 1.00 35.85 ? -34 U   B O2    1 
ATOM   6166 N  N3    . U   B 2 2   ? 98.149  108.353 126.019 1.00 35.85 ? -34 U   B N3    1 
ATOM   6167 C  C4    . U   B 2 2   ? 97.242  108.714 126.985 1.00 35.85 ? -34 U   B C4    1 
ATOM   6168 O  O4    . U   B 2 2   ? 96.047  108.718 126.712 1.00 35.85 ? -34 U   B O4    1 
ATOM   6169 C  C5    . U   B 2 2   ? 97.814  109.061 128.241 1.00 35.85 ? -34 U   B C5    1 
ATOM   6170 C  C6    . U   B 2 2   ? 99.139  109.008 128.387 1.00 35.85 ? -34 U   B C6    1 
ATOM   6171 P  P     . G   B 2 3   ? 102.606 113.245 127.875 1.00 35.85 ? -33 G   B P     1 
ATOM   6172 O  OP1   . G   B 2 3   ? 103.715 114.185 128.155 1.00 35.85 ? -33 G   B OP1   1 
ATOM   6173 O  OP2   . G   B 2 3   ? 101.288 113.471 128.512 1.00 35.85 ? -33 G   B OP2   1 
ATOM   6174 O  "O5'" . G   B 2 3   ? 102.386 113.186 126.300 1.00 35.85 ? -33 G   B "O5'" 1 
ATOM   6175 C  "C5'" . G   B 2 3   ? 103.451 112.836 125.431 1.00 35.85 ? -33 G   B "C5'" 1 
ATOM   6176 C  "C4'" . G   B 2 3   ? 102.963 112.562 124.032 1.00 35.85 ? -33 G   B "C4'" 1 
ATOM   6177 O  "O4'" . G   B 2 3   ? 102.079 111.414 124.029 1.00 35.85 ? -33 G   B "O4'" 1 
ATOM   6178 C  "C3'" . G   B 2 3   ? 102.138 113.658 123.384 1.00 35.85 ? -33 G   B "C3'" 1 
ATOM   6179 O  "O3'" . G   B 2 3   ? 102.936 114.707 122.865 1.00 35.85 ? -33 G   B "O3'" 1 
ATOM   6180 C  "C2'" . G   B 2 3   ? 101.358 112.896 122.319 1.00 35.85 ? -33 G   B "C2'" 1 
ATOM   6181 O  "O2'" . G   B 2 3   ? 102.170 112.641 121.184 1.00 35.85 ? -33 G   B "O2'" 1 
ATOM   6182 C  "C1'" . G   B 2 3   ? 101.100 111.565 123.024 1.00 35.85 ? -33 G   B "C1'" 1 
ATOM   6183 N  N9    . G   B 2 3   ? 99.761  111.509 123.640 1.00 35.85 ? -33 G   B N9    1 
ATOM   6184 C  C8    . G   B 2 3   ? 99.428  111.805 124.933 1.00 35.85 ? -33 G   B C8    1 
ATOM   6185 N  N7    . G   B 2 3   ? 98.158  111.666 125.179 1.00 35.85 ? -33 G   B N7    1 
ATOM   6186 C  C5    . G   B 2 3   ? 97.617  111.251 123.975 1.00 35.85 ? -33 G   B C5    1 
ATOM   6187 C  C6    . G   B 2 3   ? 96.281  110.942 123.627 1.00 35.85 ? -33 G   B C6    1 
ATOM   6188 O  O6    . G   B 2 3   ? 95.274  110.969 124.337 1.00 35.85 ? -33 G   B O6    1 
ATOM   6189 N  N1    . G   B 2 3   ? 96.170  110.565 122.299 1.00 35.85 ? -33 G   B N1    1 
ATOM   6190 C  C2    . G   B 2 3   ? 97.209  110.496 121.414 1.00 35.85 ? -33 G   B C2    1 
ATOM   6191 N  N2    . G   B 2 3   ? 96.899  110.114 120.172 1.00 35.85 ? -33 G   B N2    1 
ATOM   6192 N  N3    . G   B 2 3   ? 98.458  110.783 121.724 1.00 35.85 ? -33 G   B N3    1 
ATOM   6193 C  C4    . G   B 2 3   ? 98.591  111.151 123.014 1.00 35.85 ? -33 G   B C4    1 
ATOM   6194 P  P     . C   B 2 4   ? 102.647 116.234 123.267 1.00 35.85 ? -32 C   B P     1 
ATOM   6195 O  OP1   . C   B 2 4   ? 103.928 116.971 123.222 1.00 35.85 ? -32 C   B OP1   1 
ATOM   6196 O  OP2   . C   B 2 4   ? 101.843 116.254 124.507 1.00 35.85 ? -32 C   B OP2   1 
ATOM   6197 O  "O5'" . C   B 2 4   ? 101.745 116.770 122.074 1.00 35.85 ? -32 C   B "O5'" 1 
ATOM   6198 C  "C5'" . C   B 2 4   ? 102.149 116.593 120.727 1.00 35.85 ? -32 C   B "C5'" 1 
ATOM   6199 C  "C4'" . C   B 2 4   ? 100.967 116.609 119.796 1.00 35.85 ? -32 C   B "C4'" 1 
ATOM   6200 O  "O4'" . C   B 2 4   ? 100.212 115.379 119.937 1.00 35.85 ? -32 C   B "O4'" 1 
ATOM   6201 C  "C3'" . C   B 2 4   ? 99.943  117.700 120.050 1.00 35.85 ? -32 C   B "C3'" 1 
ATOM   6202 O  "O3'" . C   B 2 4   ? 100.328 118.951 119.514 1.00 35.85 ? -32 C   B "O3'" 1 
ATOM   6203 C  "C2'" . C   B 2 4   ? 98.680  117.122 119.428 1.00 35.85 ? -32 C   B "C2'" 1 
ATOM   6204 O  "O2'" . C   B 2 4   ? 98.691  117.286 118.020 1.00 35.85 ? -32 C   B "O2'" 1 
ATOM   6205 C  "C1'" . C   B 2 4   ? 98.838  115.634 119.745 1.00 35.85 ? -32 C   B "C1'" 1 
ATOM   6206 N  N1    . C   B 2 4   ? 98.096  115.254 120.970 1.00 35.85 ? -32 C   B N1    1 
ATOM   6207 C  C2    . C   B 2 4   ? 96.766  114.875 120.833 1.00 35.85 ? -32 C   B C2    1 
ATOM   6208 O  O2    . C   B 2 4   ? 96.271  114.856 119.701 1.00 35.85 ? -32 C   B O2    1 
ATOM   6209 N  N3    . C   B 2 4   ? 96.054  114.537 121.923 1.00 35.85 ? -32 C   B N3    1 
ATOM   6210 C  C4    . C   B 2 4   ? 96.622  114.569 123.120 1.00 35.85 ? -32 C   B C4    1 
ATOM   6211 N  N4    . C   B 2 4   ? 95.875  114.227 124.166 1.00 35.85 ? -32 C   B N4    1 
ATOM   6212 C  C5    . C   B 2 4   ? 97.976  114.956 123.300 1.00 35.85 ? -32 C   B C5    1 
ATOM   6213 C  C6    . C   B 2 4   ? 98.668  115.288 122.208 1.00 35.85 ? -32 C   B C6    1 
ATOM   6214 P  P     . U   B 2 5   ? 100.035 120.303 120.325 1.00 32.91 ? -31 U   B P     1 
ATOM   6215 O  OP1   . U   B 2 5   ? 100.736 121.421 119.653 1.00 32.91 ? -31 U   B OP1   1 
ATOM   6216 O  OP2   . U   B 2 5   ? 100.272 120.050 121.762 1.00 32.91 ? -31 U   B OP2   1 
ATOM   6217 O  "O5'" . U   B 2 5   ? 98.475  120.525 120.137 1.00 32.91 ? -31 U   B "O5'" 1 
ATOM   6218 C  "C5'" . U   B 2 5   ? 97.909  120.655 118.846 1.00 32.91 ? -31 U   B "C5'" 1 
ATOM   6219 C  "C4'" . U   B 2 5   ? 96.641  121.459 118.900 1.00 32.91 ? -31 U   B "C4'" 1 
ATOM   6220 O  "O4'" . U   B 2 5   ? 95.706  120.830 119.811 1.00 32.91 ? -31 U   B "O4'" 1 
ATOM   6221 C  "C3'" . U   B 2 5   ? 96.786  122.864 119.448 1.00 32.91 ? -31 U   B "C3'" 1 
ATOM   6222 O  "O3'" . U   B 2 5   ? 97.265  123.785 118.489 1.00 32.91 ? -31 U   B "O3'" 1 
ATOM   6223 C  "C2'" . U   B 2 5   ? 95.382  123.173 119.940 1.00 32.91 ? -31 U   B "C2'" 1 
ATOM   6224 O  "O2'" . U   B 2 5   ? 94.537  123.503 118.851 1.00 32.91 ? -31 U   B "O2'" 1 
ATOM   6225 C  "C1'" . U   B 2 5   ? 94.952  121.816 120.484 1.00 32.91 ? -31 U   B "C1'" 1 
ATOM   6226 N  N1    . U   B 2 5   ? 95.197  121.694 121.938 1.00 32.91 ? -31 U   B N1    1 
ATOM   6227 C  C2    . U   B 2 5   ? 94.383  122.405 122.795 1.00 32.91 ? -31 U   B C2    1 
ATOM   6228 O  O2    . U   B 2 5   ? 93.483  123.126 122.414 1.00 32.91 ? -31 U   B O2    1 
ATOM   6229 N  N3    . U   B 2 5   ? 94.661  122.245 124.126 1.00 32.91 ? -31 U   B N3    1 
ATOM   6230 C  C4    . U   B 2 5   ? 95.647  121.455 124.676 1.00 32.91 ? -31 U   B C4    1 
ATOM   6231 O  O4    . U   B 2 5   ? 95.772  121.411 125.899 1.00 32.91 ? -31 U   B O4    1 
ATOM   6232 C  C5    . U   B 2 5   ? 96.443  120.745 123.725 1.00 32.91 ? -31 U   B C5    1 
ATOM   6233 C  C6    . U   B 2 5   ? 96.194  120.885 122.423 1.00 32.91 ? -31 U   B C6    1 
ATOM   6234 P  P     . G   B 2 6   ? 98.558  124.678 118.804 1.00 30.66 ? -30 G   B P     1 
ATOM   6235 O  OP1   . G   B 2 6   ? 99.746  124.006 118.233 1.00 30.66 ? -30 G   B OP1   1 
ATOM   6236 O  OP2   . G   B 2 6   ? 98.555  125.030 120.239 1.00 30.66 ? -30 G   B OP2   1 
ATOM   6237 O  "O5'" . G   B 2 6   ? 98.288  126.014 117.995 1.00 30.66 ? -30 G   B "O5'" 1 
ATOM   6238 C  "C5'" . G   B 2 6   ? 97.832  127.175 118.663 1.00 30.66 ? -30 G   B "C5'" 1 
ATOM   6239 C  "C4'" . G   B 2 6   ? 96.333  127.303 118.599 1.00 30.66 ? -30 G   B "C4'" 1 
ATOM   6240 O  "O4'" . G   B 2 6   ? 95.716  126.228 119.350 1.00 30.66 ? -30 G   B "O4'" 1 
ATOM   6241 C  "C3'" . G   B 2 6   ? 95.767  128.564 119.227 1.00 30.66 ? -30 G   B "C3'" 1 
ATOM   6242 O  "O3'" . G   B 2 6   ? 95.834  129.680 118.363 1.00 30.66 ? -30 G   B "O3'" 1 
ATOM   6243 C  "C2'" . G   B 2 6   ? 94.350  128.150 119.591 1.00 30.66 ? -30 G   B "C2'" 1 
ATOM   6244 O  "O2'" . G   B 2 6   ? 93.518  128.153 118.443 1.00 30.66 ? -30 G   B "O2'" 1 
ATOM   6245 C  "C1'" . G   B 2 6   ? 94.567  126.703 120.022 1.00 30.66 ? -30 G   B "C1'" 1 
ATOM   6246 N  N9    . G   B 2 6   ? 94.797  126.581 121.474 1.00 30.66 ? -30 G   B N9    1 
ATOM   6247 C  C8    . G   B 2 6   ? 95.880  125.986 122.068 1.00 30.66 ? -30 G   B C8    1 
ATOM   6248 N  N7    . G   B 2 6   ? 95.839  126.005 123.367 1.00 30.66 ? -30 G   B N7    1 
ATOM   6249 C  C5    . G   B 2 6   ? 94.650  126.650 123.655 1.00 30.66 ? -30 G   B C5    1 
ATOM   6250 C  C6    . G   B 2 6   ? 94.070  126.963 124.907 1.00 30.66 ? -30 G   B C6    1 
ATOM   6251 O  O6    . G   B 2 6   ? 94.512  126.721 126.034 1.00 30.66 ? -30 G   B O6    1 
ATOM   6252 N  N1    . G   B 2 6   ? 92.857  127.619 124.761 1.00 30.66 ? -30 G   B N1    1 
ATOM   6253 C  C2    . G   B 2 6   ? 92.277  127.936 123.563 1.00 30.66 ? -30 G   B C2    1 
ATOM   6254 N  N2    . G   B 2 6   ? 91.101  128.571 123.626 1.00 30.66 ? -30 G   B N2    1 
ATOM   6255 N  N3    . G   B 2 6   ? 92.807  127.651 122.387 1.00 30.66 ? -30 G   B N3    1 
ATOM   6256 C  C4    . G   B 2 6   ? 93.990  127.011 122.502 1.00 30.66 ? -30 G   B C4    1 
ATOM   6257 P  P     . G   B 2 7   ? 96.623  130.998 118.818 1.00 41.44 ? -29 G   B P     1 
ATOM   6258 O  OP1   . G   B 2 7   ? 96.954  131.779 117.601 1.00 41.44 ? -29 G   B OP1   1 
ATOM   6259 O  OP2   . G   B 2 7   ? 97.702  130.586 119.744 1.00 41.44 ? -29 G   B OP2   1 
ATOM   6260 O  "O5'" . G   B 2 7   ? 95.533  131.817 119.634 1.00 41.44 ? -29 G   B "O5'" 1 
ATOM   6261 C  "C5'" . G   B 2 7   ? 94.297  132.155 119.029 1.00 41.44 ? -29 G   B "C5'" 1 
ATOM   6262 C  "C4'" . G   B 2 7   ? 93.309  132.685 120.034 1.00 41.44 ? -29 G   B "C4'" 1 
ATOM   6263 O  "O4'" . G   B 2 7   ? 92.883  131.625 120.924 1.00 41.44 ? -29 G   B "O4'" 1 
ATOM   6264 C  "C3'" . G   B 2 7   ? 93.817  133.760 120.975 1.00 41.44 ? -29 G   B "C3'" 1 
ATOM   6265 O  "O3'" . G   B 2 7   ? 93.873  135.039 120.374 1.00 41.44 ? -29 G   B "O3'" 1 
ATOM   6266 C  "C2'" . G   B 2 7   ? 92.831  133.668 122.130 1.00 41.44 ? -29 G   B "C2'" 1 
ATOM   6267 O  "O2'" . G   B 2 7   ? 91.606  134.298 121.789 1.00 41.44 ? -29 G   B "O2'" 1 
ATOM   6268 C  "C1'" . G   B 2 7   ? 92.586  132.162 122.195 1.00 41.44 ? -29 G   B "C1'" 1 
ATOM   6269 N  N9    . G   B 2 7   ? 93.433  131.501 123.201 1.00 41.44 ? -29 G   B N9    1 
ATOM   6270 C  C8    . G   B 2 7   ? 94.512  130.687 122.975 1.00 41.44 ? -29 G   B C8    1 
ATOM   6271 N  N7    . G   B 2 7   ? 95.053  130.243 124.074 1.00 41.44 ? -29 G   B N7    1 
ATOM   6272 C  C5    . G   B 2 7   ? 94.283  130.798 125.086 1.00 41.44 ? -29 G   B C5    1 
ATOM   6273 C  C6    . G   B 2 7   ? 94.388  130.677 126.495 1.00 41.44 ? -29 G   B C6    1 
ATOM   6274 O  O6    . G   B 2 7   ? 95.212  130.033 127.152 1.00 41.44 ? -29 G   B O6    1 
ATOM   6275 N  N1    . G   B 2 7   ? 93.401  131.408 127.145 1.00 41.44 ? -29 G   B N1    1 
ATOM   6276 C  C2    . G   B 2 7   ? 92.435  132.157 126.524 1.00 41.44 ? -29 G   B C2    1 
ATOM   6277 N  N2    . G   B 2 7   ? 91.570  132.788 127.326 1.00 41.44 ? -29 G   B N2    1 
ATOM   6278 N  N3    . G   B 2 7   ? 92.324  132.278 125.214 1.00 41.44 ? -29 G   B N3    1 
ATOM   6279 C  C4    . G   B 2 7   ? 93.276  131.577 124.562 1.00 41.44 ? -29 G   B C4    1 
ATOM   6280 P  P     . C   B 2 8   ? 95.154  135.977 120.604 1.00 44.82 ? -28 C   B P     1 
ATOM   6281 O  OP1   . C   B 2 8   ? 95.077  137.109 119.649 1.00 44.82 ? -28 C   B OP1   1 
ATOM   6282 O  OP2   . C   B 2 8   ? 96.356  135.108 120.625 1.00 44.82 ? -28 C   B OP2   1 
ATOM   6283 O  "O5'" . C   B 2 8   ? 94.942  136.550 122.074 1.00 44.82 ? -28 C   B "O5'" 1 
ATOM   6284 C  "C5'" . C   B 2 8   ? 93.744  137.225 122.425 1.00 44.82 ? -28 C   B "C5'" 1 
ATOM   6285 C  "C4'" . C   B 2 8   ? 93.538  137.240 123.919 1.00 44.82 ? -28 C   B "C4'" 1 
ATOM   6286 O  "O4'" . C   B 2 8   ? 93.433  135.881 124.413 1.00 44.82 ? -28 C   B "O4'" 1 
ATOM   6287 C  "C3'" . C   B 2 8   ? 94.665  137.841 124.741 1.00 44.82 ? -28 C   B "C3'" 1 
ATOM   6288 O  "O3'" . C   B 2 8   ? 94.632  139.256 124.770 1.00 44.82 ? -28 C   B "O3'" 1 
ATOM   6289 C  "C2'" . C   B 2 8   ? 94.461  137.194 126.104 1.00 44.82 ? -28 C   B "C2'" 1 
ATOM   6290 O  "O2'" . C   B 2 8   ? 93.407  137.833 126.807 1.00 44.82 ? -28 C   B "O2'" 1 
ATOM   6291 C  "C1'" . C   B 2 8   ? 93.991  135.795 125.707 1.00 44.82 ? -28 C   B "C1'" 1 
ATOM   6292 N  N1    . C   B 2 8   ? 95.097  134.815 125.685 1.00 44.82 ? -28 C   B N1    1 
ATOM   6293 C  C2    . C   B 2 8   ? 95.531  134.274 126.892 1.00 44.82 ? -28 C   B C2    1 
ATOM   6294 O  O2    . C   B 2 8   ? 94.979  134.637 127.938 1.00 44.82 ? -28 C   B O2    1 
ATOM   6295 N  N3    . C   B 2 8   ? 96.538  133.375 126.892 1.00 44.82 ? -28 C   B N3    1 
ATOM   6296 C  C4    . C   B 2 8   ? 97.105  133.011 125.747 1.00 44.82 ? -28 C   B C4    1 
ATOM   6297 N  N4    . C   B 2 8   ? 98.095  132.121 125.796 1.00 44.82 ? -28 C   B N4    1 
ATOM   6298 C  C5    . C   B 2 8   ? 96.682  133.543 124.501 1.00 44.82 ? -28 C   B C5    1 
ATOM   6299 C  C6    . C   B 2 8   ? 95.684  134.432 124.517 1.00 44.82 ? -28 C   B C6    1 
ATOM   6300 P  P     . C   B 2 9   ? 96.000  140.096 124.779 1.00 53.73 ? -27 C   B P     1 
ATOM   6301 O  OP1   . C   B 2 9   ? 95.685  141.498 124.417 1.00 53.73 ? -27 C   B OP1   1 
ATOM   6302 O  OP2   . C   B 2 9   ? 97.002  139.342 123.989 1.00 53.73 ? -27 C   B OP2   1 
ATOM   6303 O  "O5'" . C   B 2 9   ? 96.459  140.064 126.303 1.00 53.73 ? -27 C   B "O5'" 1 
ATOM   6304 C  "C5'" . C   B 2 9   ? 95.589  140.498 127.337 1.00 53.73 ? -27 C   B "C5'" 1 
ATOM   6305 C  "C4'" . C   B 2 9   ? 96.084  140.061 128.692 1.00 53.73 ? -27 C   B "C4'" 1 
ATOM   6306 O  "O4'" . C   B 2 9   ? 96.125  138.616 128.756 1.00 53.73 ? -27 C   B "O4'" 1 
ATOM   6307 C  "C3'" . C   B 2 9   ? 97.497  140.488 129.052 1.00 53.73 ? -27 C   B "C3'" 1 
ATOM   6308 O  "O3'" . C   B 2 9   ? 97.550  141.818 129.538 1.00 53.73 ? -27 C   B "O3'" 1 
ATOM   6309 C  "C2'" . C   B 2 9   ? 97.916  139.448 130.085 1.00 53.73 ? -27 C   B "C2'" 1 
ATOM   6310 O  "O2'" . C   B 2 9   ? 97.415  139.786 131.369 1.00 53.73 ? -27 C   B "O2'" 1 
ATOM   6311 C  "C1'" . C   B 2 9   ? 97.180  138.199 129.593 1.00 53.73 ? -27 C   B "C1'" 1 
ATOM   6312 N  N1    . C   B 2 9   ? 98.051  137.270 128.841 1.00 53.73 ? -27 C   B N1    1 
ATOM   6313 C  C2    . C   B 2 9   ? 98.823  136.360 129.561 1.00 53.73 ? -27 C   B C2    1 
ATOM   6314 O  O2    . C   B 2 9   ? 98.764  136.375 130.797 1.00 53.73 ? -27 C   B O2    1 
ATOM   6315 N  N3    . C   B 2 9   ? 99.617  135.492 128.899 1.00 53.73 ? -27 C   B N3    1 
ATOM   6316 C  C4    . C   B 2 9   ? 99.652  135.509 127.570 1.00 53.73 ? -27 C   B C4    1 
ATOM   6317 N  N4    . C   B 2 9   ? 100.450 134.635 126.959 1.00 53.73 ? -27 C   B N4    1 
ATOM   6318 C  C5    . C   B 2 9   ? 98.870  136.422 126.807 1.00 53.73 ? -27 C   B C5    1 
ATOM   6319 C  C6    . C   B 2 9   ? 98.087  137.275 127.478 1.00 53.73 ? -27 C   B C6    1 
ATOM   6320 P  P     . G   B 2 10  ? 98.495  142.902 128.824 1.00 61.90 ? -26 G   B P     1 
ATOM   6321 O  OP1   . G   B 2 10  ? 98.687  144.036 129.761 1.00 61.90 ? -26 G   B OP1   1 
ATOM   6322 O  OP2   . G   B 2 10  ? 97.955  143.167 127.466 1.00 61.90 ? -26 G   B OP2   1 
ATOM   6323 O  "O5'" . G   B 2 10  ? 99.883  142.140 128.672 1.00 61.90 ? -26 G   B "O5'" 1 
ATOM   6324 C  "C5'" . G   B 2 10  ? 101.083 142.707 129.170 1.00 61.90 ? -26 G   B "C5'" 1 
ATOM   6325 C  "C4'" . G   B 2 10  ? 101.273 142.410 130.636 1.00 61.90 ? -26 G   B "C4'" 1 
ATOM   6326 O  "O4'" . G   B 2 10  ? 100.861 141.052 130.928 1.00 61.90 ? -26 G   B "O4'" 1 
ATOM   6327 C  "C3'" . G   B 2 10  ? 102.704 142.488 131.143 1.00 61.90 ? -26 G   B "C3'" 1 
ATOM   6328 O  "O3'" . G   B 2 10  ? 103.090 143.818 131.442 1.00 61.90 ? -26 G   B "O3'" 1 
ATOM   6329 C  "C2'" . G   B 2 10  ? 102.687 141.574 132.361 1.00 61.90 ? -26 G   B "C2'" 1 
ATOM   6330 O  "O2'" . G   B 2 10  ? 102.171 142.257 133.494 1.00 61.90 ? -26 G   B "O2'" 1 
ATOM   6331 C  "C1'" . G   B 2 10  ? 101.677 140.505 131.939 1.00 61.90 ? -26 G   B "C1'" 1 
ATOM   6332 N  N9    . G   B 2 10  ? 102.312 139.268 131.438 1.00 61.90 ? -26 G   B N9    1 
ATOM   6333 C  C8    . G   B 2 10  ? 103.002 138.350 132.192 1.00 61.90 ? -26 G   B C8    1 
ATOM   6334 N  N7    . G   B 2 10  ? 103.456 137.345 131.500 1.00 61.90 ? -26 G   B N7    1 
ATOM   6335 C  C5    . G   B 2 10  ? 103.039 137.611 130.208 1.00 61.90 ? -26 G   B C5    1 
ATOM   6336 C  C6    . G   B 2 10  ? 103.237 136.871 129.020 1.00 61.90 ? -26 G   B C6    1 
ATOM   6337 O  O6    . G   B 2 10  ? 103.835 135.804 128.872 1.00 61.90 ? -26 G   B O6    1 
ATOM   6338 N  N1    . G   B 2 10  ? 102.653 137.488 127.923 1.00 61.90 ? -26 G   B N1    1 
ATOM   6339 C  C2    . G   B 2 10  ? 101.964 138.670 127.962 1.00 61.90 ? -26 G   B C2    1 
ATOM   6340 N  N2    . G   B 2 10  ? 101.470 139.112 126.798 1.00 61.90 ? -26 G   B N2    1 
ATOM   6341 N  N3    . G   B 2 10  ? 101.774 139.370 129.063 1.00 61.90 ? -26 G   B N3    1 
ATOM   6342 C  C4    . G   B 2 10  ? 102.336 138.792 130.145 1.00 61.90 ? -26 G   B C4    1 
ATOM   6343 P  P     . C   B 2 11  ? 104.611 144.289 131.245 1.00 60.97 ? -25 C   B P     1 
ATOM   6344 O  OP1   . C   B 2 11  ? 104.714 145.698 131.700 1.00 60.97 ? -25 C   B OP1   1 
ATOM   6345 O  OP2   . C   B 2 11  ? 105.040 143.936 129.869 1.00 60.97 ? -25 C   B OP2   1 
ATOM   6346 O  "O5'" . C   B 2 11  ? 105.423 143.382 132.270 1.00 60.97 ? -25 C   B "O5'" 1 
ATOM   6347 C  "C5'" . C   B 2 11  ? 106.825 143.224 132.141 1.00 60.97 ? -25 C   B "C5'" 1 
ATOM   6348 C  "C4'" . C   B 2 11  ? 107.301 141.956 132.800 1.00 60.97 ? -25 C   B "C4'" 1 
ATOM   6349 O  "O4'" . C   B 2 11  ? 106.391 140.868 132.497 1.00 60.97 ? -25 C   B "O4'" 1 
ATOM   6350 C  "C3'" . C   B 2 11  ? 108.653 141.448 132.332 1.00 60.97 ? -25 C   B "C3'" 1 
ATOM   6351 O  "O3'" . C   B 2 11  ? 109.736 142.118 132.952 1.00 60.97 ? -25 C   B "O3'" 1 
ATOM   6352 C  "C2'" . C   B 2 11  ? 108.581 139.961 132.651 1.00 60.97 ? -25 C   B "C2'" 1 
ATOM   6353 O  "O2'" . C   B 2 11  ? 108.813 139.729 134.032 1.00 60.97 ? -25 C   B "O2'" 1 
ATOM   6354 C  "C1'" . C   B 2 11  ? 107.111 139.662 132.354 1.00 60.97 ? -25 C   B "C1'" 1 
ATOM   6355 N  N1    . C   B 2 11  ? 106.899 139.152 130.980 1.00 60.97 ? -25 C   B N1    1 
ATOM   6356 C  C2    . C   B 2 11  ? 107.346 137.874 130.621 1.00 60.97 ? -25 C   B C2    1 
ATOM   6357 O  O2    . C   B 2 11  ? 107.936 137.168 131.451 1.00 60.97 ? -25 C   B O2    1 
ATOM   6358 N  N3    . C   B 2 11  ? 107.130 137.434 129.362 1.00 60.97 ? -25 C   B N3    1 
ATOM   6359 C  C4    . C   B 2 11  ? 106.494 138.207 128.482 1.00 60.97 ? -25 C   B C4    1 
ATOM   6360 N  N4    . C   B 2 11  ? 106.302 137.729 127.252 1.00 60.97 ? -25 C   B N4    1 
ATOM   6361 C  C5    . C   B 2 11  ? 106.023 139.505 128.821 1.00 60.97 ? -25 C   B C5    1 
ATOM   6362 C  C6    . C   B 2 11  ? 106.244 139.929 130.069 1.00 60.97 ? -25 C   B C6    1 
ATOM   6363 P  P     . U   B 2 12  ? 110.778 142.954 132.062 1.00 55.75 ? -24 U   B P     1 
ATOM   6364 O  OP1   . U   B 2 12  ? 111.581 143.805 132.973 1.00 55.75 ? -24 U   B OP1   1 
ATOM   6365 O  OP2   . U   B 2 12  ? 110.029 143.582 130.944 1.00 55.75 ? -24 U   B OP2   1 
ATOM   6366 O  "O5'" . U   B 2 12  ? 111.739 141.837 131.458 1.00 55.75 ? -24 U   B "O5'" 1 
ATOM   6367 C  "C5'" . U   B 2 12  ? 112.455 140.963 132.315 1.00 55.75 ? -24 U   B "C5'" 1 
ATOM   6368 C  "C4'" . U   B 2 12  ? 112.935 139.737 131.582 1.00 55.75 ? -24 U   B "C4'" 1 
ATOM   6369 O  "O4'" . U   B 2 12  ? 111.799 138.962 131.124 1.00 55.75 ? -24 U   B "O4'" 1 
ATOM   6370 C  "C3'" . U   B 2 12  ? 113.741 139.987 130.319 1.00 55.75 ? -24 U   B "C3'" 1 
ATOM   6371 O  "O3'" . U   B 2 12  ? 115.095 140.304 130.580 1.00 55.75 ? -24 U   B "O3'" 1 
ATOM   6372 C  "C2'" . U   B 2 12  ? 113.552 138.689 129.546 1.00 55.75 ? -24 U   B "C2'" 1 
ATOM   6373 O  "O2'" . U   B 2 12  ? 114.390 137.669 130.069 1.00 55.75 ? -24 U   B "O2'" 1 
ATOM   6374 C  "C1'" . U   B 2 12  ? 112.104 138.342 129.892 1.00 55.75 ? -24 U   B "C1'" 1 
ATOM   6375 N  N1    . U   B 2 12  ? 111.150 138.827 128.870 1.00 55.75 ? -24 U   B N1    1 
ATOM   6376 C  C2    . U   B 2 12  ? 110.917 138.016 127.781 1.00 55.75 ? -24 U   B C2    1 
ATOM   6377 O  O2    . U   B 2 12  ? 111.465 136.939 127.633 1.00 55.75 ? -24 U   B O2    1 
ATOM   6378 N  N3    . U   B 2 12  ? 110.020 138.512 126.872 1.00 55.75 ? -24 U   B N3    1 
ATOM   6379 C  C4    . U   B 2 12  ? 109.349 139.712 126.944 1.00 55.75 ? -24 U   B C4    1 
ATOM   6380 O  O4    . U   B 2 12  ? 108.570 140.025 126.045 1.00 55.75 ? -24 U   B O4    1 
ATOM   6381 C  C5    . U   B 2 12  ? 109.640 140.494 128.101 1.00 55.75 ? -24 U   B C5    1 
ATOM   6382 C  C6    . U   B 2 12  ? 110.508 140.035 129.002 1.00 55.75 ? -24 U   B C6    1 
ATOM   6383 P  P     . C   B 2 13  ? 115.962 141.094 129.485 1.00 49.78 ? -23 C   B P     1 
ATOM   6384 O  OP1   . C   B 2 13  ? 116.946 141.945 130.199 1.00 49.78 ? -23 C   B OP1   1 
ATOM   6385 O  OP2   . C   B 2 13  ? 115.030 141.712 128.510 1.00 49.78 ? -23 C   B OP2   1 
ATOM   6386 O  "O5'" . C   B 2 13  ? 116.761 139.943 128.735 1.00 49.78 ? -23 C   B "O5'" 1 
ATOM   6387 C  "C5'" . C   B 2 13  ? 117.369 140.183 127.477 1.00 49.78 ? -23 C   B "C5'" 1 
ATOM   6388 C  "C4'" . C   B 2 13  ? 117.286 138.967 126.592 1.00 49.78 ? -23 C   B "C4'" 1 
ATOM   6389 O  "O4'" . C   B 2 13  ? 115.943 138.424 126.639 1.00 49.78 ? -23 C   B "O4'" 1 
ATOM   6390 C  "C3'" . C   B 2 13  ? 117.540 139.206 125.112 1.00 49.78 ? -23 C   B "C3'" 1 
ATOM   6391 O  "O3'" . C   B 2 13  ? 118.920 139.247 124.797 1.00 49.78 ? -23 C   B "O3'" 1 
ATOM   6392 C  "C2'" . C   B 2 13  ? 116.797 138.051 124.454 1.00 49.78 ? -23 C   B "C2'" 1 
ATOM   6393 O  "O2'" . C   B 2 13  ? 117.567 136.860 124.524 1.00 49.78 ? -23 C   B "O2'" 1 
ATOM   6394 C  "C1'" . C   B 2 13  ? 115.589 137.896 125.380 1.00 49.78 ? -23 C   B "C1'" 1 
ATOM   6395 N  N1    . C   B 2 13  ? 114.391 138.616 124.891 1.00 49.78 ? -23 C   B N1    1 
ATOM   6396 C  C2    . C   B 2 13  ? 113.637 138.062 123.859 1.00 49.78 ? -23 C   B C2    1 
ATOM   6397 O  O2    . C   B 2 13  ? 114.002 136.988 123.364 1.00 49.78 ? -23 C   B O2    1 
ATOM   6398 N  N3    . C   B 2 13  ? 112.539 138.711 123.419 1.00 49.78 ? -23 C   B N3    1 
ATOM   6399 C  C4    . C   B 2 13  ? 112.178 139.865 123.976 1.00 49.78 ? -23 C   B C4    1 
ATOM   6400 N  N4    . C   B 2 13  ? 111.086 140.473 123.512 1.00 49.78 ? -23 C   B N4    1 
ATOM   6401 C  C5    . C   B 2 13  ? 112.922 140.450 125.034 1.00 49.78 ? -23 C   B C5    1 
ATOM   6402 C  C6    . C   B 2 13  ? 114.008 139.796 125.458 1.00 49.78 ? -23 C   B C6    1 
ATOM   6403 P  P     . U   B 2 14  ? 119.485 140.353 123.780 1.00 52.29 ? -22 U   B P     1 
ATOM   6404 O  OP1   . U   B 2 14  ? 120.959 140.407 123.924 1.00 52.29 ? -22 U   B OP1   1 
ATOM   6405 O  OP2   . U   B 2 14  ? 118.689 141.591 123.954 1.00 52.29 ? -22 U   B OP2   1 
ATOM   6406 O  "O5'" . U   B 2 14  ? 119.157 139.752 122.345 1.00 52.29 ? -22 U   B "O5'" 1 
ATOM   6407 C  "C5'" . U   B 2 14  ? 119.616 138.461 121.974 1.00 52.29 ? -22 U   B "C5'" 1 
ATOM   6408 C  "C4'" . U   B 2 14  ? 119.178 138.108 120.576 1.00 52.29 ? -22 U   B "C4'" 1 
ATOM   6409 O  "O4'" . U   B 2 14  ? 117.775 137.732 120.574 1.00 52.29 ? -22 U   B "O4'" 1 
ATOM   6410 C  "C3'" . U   B 2 14  ? 119.256 139.234 119.560 1.00 52.29 ? -22 U   B "C3'" 1 
ATOM   6411 O  "O3'" . U   B 2 14  ? 120.562 139.439 119.053 1.00 52.29 ? -22 U   B "O3'" 1 
ATOM   6412 C  "C2'" . U   B 2 14  ? 118.245 138.803 118.506 1.00 52.29 ? -22 U   B "C2'" 1 
ATOM   6413 O  "O2'" . U   B 2 14  ? 118.796 137.804 117.661 1.00 52.29 ? -22 U   B "O2'" 1 
ATOM   6414 C  "C1'" . U   B 2 14  ? 117.163 138.159 119.374 1.00 52.29 ? -22 U   B "C1'" 1 
ATOM   6415 N  N1    . U   B 2 14  ? 116.072 139.102 119.705 1.00 52.29 ? -22 U   B N1    1 
ATOM   6416 C  C2    . U   B 2 14  ? 115.170 139.422 118.716 1.00 52.29 ? -22 U   B C2    1 
ATOM   6417 O  O2    . U   B 2 14  ? 115.237 138.970 117.589 1.00 52.29 ? -22 U   B O2    1 
ATOM   6418 N  N3    . U   B 2 14  ? 114.183 140.297 119.088 1.00 52.29 ? -22 U   B N3    1 
ATOM   6419 C  C4    . U   B 2 14  ? 114.005 140.874 120.324 1.00 52.29 ? -22 U   B C4    1 
ATOM   6420 O  O4    . U   B 2 14  ? 113.063 141.644 120.506 1.00 52.29 ? -22 U   B O4    1 
ATOM   6421 C  C5    . U   B 2 14  ? 114.977 140.492 121.296 1.00 52.29 ? -22 U   B C5    1 
ATOM   6422 C  C6    . U   B 2 14  ? 115.949 139.640 120.961 1.00 52.29 ? -22 U   B C6    1 
ATOM   6423 P  P     . C   B 2 15  ? 121.074 140.929 118.753 1.00 50.22 ? -21 C   B P     1 
ATOM   6424 O  OP1   . C   B 2 15  ? 122.437 140.840 118.177 1.00 50.22 ? -21 C   B OP1   1 
ATOM   6425 O  OP2   . C   B 2 15  ? 120.837 141.757 119.959 1.00 50.22 ? -21 C   B OP2   1 
ATOM   6426 O  "O5'" . C   B 2 15  ? 120.093 141.445 117.612 1.00 50.22 ? -21 C   B "O5'" 1 
ATOM   6427 C  "C5'" . C   B 2 15  ? 120.565 141.623 116.288 1.00 50.22 ? -21 C   B "C5'" 1 
ATOM   6428 C  "C4'" . C   B 2 15  ? 119.552 141.187 115.257 1.00 50.22 ? -21 C   B "C4'" 1 
ATOM   6429 O  "O4'" . C   B 2 15  ? 118.320 140.760 115.898 1.00 50.22 ? -21 C   B "O4'" 1 
ATOM   6430 C  "C3'" . C   B 2 15  ? 119.106 142.266 114.290 1.00 50.22 ? -21 C   B "C3'" 1 
ATOM   6431 O  "O3'" . C   B 2 15  ? 120.037 142.490 113.251 1.00 50.22 ? -21 C   B "O3'" 1 
ATOM   6432 C  "C2'" . C   B 2 15  ? 117.758 141.749 113.812 1.00 50.22 ? -21 C   B "C2'" 1 
ATOM   6433 O  "O2'" . C   B 2 15  ? 117.934 140.727 112.844 1.00 50.22 ? -21 C   B "O2'" 1 
ATOM   6434 C  "C1'" . C   B 2 15  ? 117.213 141.109 115.091 1.00 50.22 ? -21 C   B "C1'" 1 
ATOM   6435 N  N1    . C   B 2 15  ? 116.341 142.026 115.865 1.00 50.22 ? -21 C   B N1    1 
ATOM   6436 C  C2    . C   B 2 15  ? 115.108 142.458 115.361 1.00 50.22 ? -21 C   B C2    1 
ATOM   6437 O  O2    . C   B 2 15  ? 114.729 142.088 114.243 1.00 50.22 ? -21 C   B O2    1 
ATOM   6438 N  N3    . C   B 2 15  ? 114.343 143.288 116.104 1.00 50.22 ? -21 C   B N3    1 
ATOM   6439 C  C4    . C   B 2 15  ? 114.753 143.682 117.307 1.00 50.22 ? -21 C   B C4    1 
ATOM   6440 N  N4    . C   B 2 15  ? 113.963 144.500 118.003 1.00 50.22 ? -21 C   B N4    1 
ATOM   6441 C  C5    . C   B 2 15  ? 115.993 143.256 117.851 1.00 50.22 ? -21 C   B C5    1 
ATOM   6442 C  C6    . C   B 2 15  ? 116.739 142.437 117.105 1.00 50.22 ? -21 C   B C6    1 
ATOM   6443 P  P     . G   B 2 16  ? 120.283 143.983 112.726 1.00 58.51 ? -20 G   B P     1 
ATOM   6444 O  OP1   . G   B 2 16  ? 121.329 143.949 111.674 1.00 58.51 ? -20 G   B OP1   1 
ATOM   6445 O  OP2   . G   B 2 16  ? 120.471 144.850 113.914 1.00 58.51 ? -20 G   B OP2   1 
ATOM   6446 O  "O5'" . G   B 2 16  ? 118.896 144.366 112.047 1.00 58.51 ? -20 G   B "O5'" 1 
ATOM   6447 C  "C5'" . G   B 2 16  ? 118.411 145.695 112.090 1.00 58.51 ? -20 G   B "C5'" 1 
ATOM   6448 C  "C4'" . G   B 2 16  ? 116.992 145.782 111.595 1.00 58.51 ? -20 G   B "C4'" 1 
ATOM   6449 O  "O4'" . G   B 2 16  ? 116.098 145.126 112.529 1.00 58.51 ? -20 G   B "O4'" 1 
ATOM   6450 C  "C3'" . G   B 2 16  ? 116.435 147.187 111.475 1.00 58.51 ? -20 G   B "C3'" 1 
ATOM   6451 O  "O3'" . G   B 2 16  ? 116.839 147.822 110.276 1.00 58.51 ? -20 G   B "O3'" 1 
ATOM   6452 C  "C2'" . G   B 2 16  ? 114.932 146.967 111.581 1.00 58.51 ? -20 G   B "C2'" 1 
ATOM   6453 O  "O2'" . G   B 2 16  ? 114.404 146.530 110.340 1.00 58.51 ? -20 G   B "O2'" 1 
ATOM   6454 C  "C1'" . G   B 2 16  ? 114.860 145.805 112.572 1.00 58.51 ? -20 G   B "C1'" 1 
ATOM   6455 N  N9    . G   B 2 16  ? 114.610 146.258 113.955 1.00 58.51 ? -20 G   B N9    1 
ATOM   6456 C  C8    . G   B 2 16  ? 115.487 146.197 115.010 1.00 58.51 ? -20 G   B C8    1 
ATOM   6457 N  N7    . G   B 2 16  ? 114.993 146.667 116.121 1.00 58.51 ? -20 G   B N7    1 
ATOM   6458 C  C5    . G   B 2 16  ? 113.707 147.060 115.783 1.00 58.51 ? -20 G   B C5    1 
ATOM   6459 C  C6    . G   B 2 16  ? 112.690 147.644 116.580 1.00 58.51 ? -20 G   B C6    1 
ATOM   6460 O  O6    . G   B 2 16  ? 112.722 147.940 117.779 1.00 58.51 ? -20 G   B O6    1 
ATOM   6461 N  N1    . G   B 2 16  ? 111.538 147.887 115.848 1.00 58.51 ? -20 G   B N1    1 
ATOM   6462 C  C2    . G   B 2 16  ? 111.383 147.603 114.520 1.00 58.51 ? -20 G   B C2    1 
ATOM   6463 N  N2    . G   B 2 16  ? 110.189 147.914 113.996 1.00 58.51 ? -20 G   B N2    1 
ATOM   6464 N  N3    . G   B 2 16  ? 112.322 147.059 113.763 1.00 58.51 ? -20 G   B N3    1 
ATOM   6465 C  C4    . G   B 2 16  ? 113.453 146.814 114.453 1.00 58.51 ? -20 G   B C4    1 
ATOM   6466 P  P     . C   B 2 17  ? 116.760 149.418 110.143 1.00 62.78 ? -19 C   B P     1 
ATOM   6467 O  OP1   . C   B 2 17  ? 117.475 149.819 108.906 1.00 62.78 ? -19 C   B OP1   1 
ATOM   6468 O  OP2   . C   B 2 17  ? 117.164 150.004 111.444 1.00 62.78 ? -19 C   B OP2   1 
ATOM   6469 O  "O5'" . C   B 2 17  ? 115.209 149.698 109.927 1.00 62.78 ? -19 C   B "O5'" 1 
ATOM   6470 C  "C5'" . C   B 2 17  ? 114.674 150.996 110.107 1.00 62.78 ? -19 C   B "C5'" 1 
ATOM   6471 C  "C4'" . C   B 2 17  ? 113.328 150.944 110.779 1.00 62.78 ? -19 C   B "C4'" 1 
ATOM   6472 O  "O4'" . C   B 2 17  ? 113.368 150.012 111.890 1.00 62.78 ? -19 C   B "O4'" 1 
ATOM   6473 C  "C3'" . C   B 2 17  ? 112.860 152.245 111.403 1.00 62.78 ? -19 C   B "C3'" 1 
ATOM   6474 O  "O3'" . C   B 2 17  ? 112.281 153.125 110.457 1.00 62.78 ? -19 C   B "O3'" 1 
ATOM   6475 C  "C2'" . C   B 2 17  ? 111.885 151.774 112.474 1.00 62.78 ? -19 C   B "C2'" 1 
ATOM   6476 O  "O2'" . C   B 2 17  ? 110.624 151.461 111.902 1.00 62.78 ? -19 C   B "O2'" 1 
ATOM   6477 C  "C1'" . C   B 2 17  ? 112.541 150.473 112.937 1.00 62.78 ? -19 C   B "C1'" 1 
ATOM   6478 N  N1    . C   B 2 17  ? 113.370 150.643 114.154 1.00 62.78 ? -19 C   B N1    1 
ATOM   6479 C  C2    . C   B 2 17  ? 112.792 151.016 115.376 1.00 62.78 ? -19 C   B C2    1 
ATOM   6480 O  O2    . C   B 2 17  ? 111.574 151.233 115.451 1.00 62.78 ? -19 C   B O2    1 
ATOM   6481 N  N3    . C   B 2 17  ? 113.582 151.148 116.464 1.00 62.78 ? -19 C   B N3    1 
ATOM   6482 C  C4    . C   B 2 17  ? 114.889 150.916 116.377 1.00 62.78 ? -19 C   B C4    1 
ATOM   6483 N  N4    . C   B 2 17  ? 115.624 151.060 117.481 1.00 62.78 ? -19 C   B N4    1 
ATOM   6484 C  C5    . C   B 2 17  ? 115.502 150.526 115.157 1.00 62.78 ? -19 C   B C5    1 
ATOM   6485 C  C6    . C   B 2 17  ? 114.711 150.401 114.087 1.00 62.78 ? -19 C   B C6    1 
ATOM   6486 P  P     . U   B 2 18  ? 113.055 154.461 110.013 1.00 72.53 ? -18 U   B P     1 
ATOM   6487 O  OP1   . U   B 2 18  ? 114.118 154.075 109.052 1.00 72.53 ? -18 U   B OP1   1 
ATOM   6488 O  OP2   . U   B 2 18  ? 113.414 155.216 111.240 1.00 72.53 ? -18 U   B OP2   1 
ATOM   6489 O  "O5'" . U   B 2 18  ? 111.952 155.294 109.220 1.00 72.53 ? -18 U   B "O5'" 1 
ATOM   6490 C  "C5'" . U   B 2 18  ? 110.815 155.823 109.886 1.00 72.53 ? -18 U   B "C5'" 1 
ATOM   6491 C  "C4'" . U   B 2 18  ? 109.602 155.811 108.991 1.00 72.53 ? -18 U   B "C4'" 1 
ATOM   6492 O  "O4'" . U   B 2 18  ? 110.028 155.853 107.607 1.00 72.53 ? -18 U   B "O4'" 1 
ATOM   6493 C  "C3'" . U   B 2 18  ? 108.722 154.572 109.076 1.00 72.53 ? -18 U   B "C3'" 1 
ATOM   6494 O  "O3'" . U   B 2 18  ? 107.802 154.630 110.153 1.00 72.53 ? -18 U   B "O3'" 1 
ATOM   6495 C  "C2'" . U   B 2 18  ? 108.045 154.529 107.708 1.00 72.53 ? -18 U   B "C2'" 1 
ATOM   6496 O  "O2'" . U   B 2 18  ? 106.899 155.369 107.689 1.00 72.53 ? -18 U   B "O2'" 1 
ATOM   6497 C  "C1'" . U   B 2 18  ? 109.112 155.149 106.799 1.00 72.53 ? -18 U   B "C1'" 1 
ATOM   6498 N  N1    . U   B 2 18  ? 109.836 154.170 105.949 1.00 72.53 ? -18 U   B N1    1 
ATOM   6499 C  C2    . U   B 2 18  ? 110.689 153.214 106.482 1.00 72.53 ? -18 U   B C2    1 
ATOM   6500 O  O2    . U   B 2 18  ? 110.934 153.087 107.667 1.00 72.53 ? -18 U   B O2    1 
ATOM   6501 N  N3    . U   B 2 18  ? 111.284 152.390 105.558 1.00 72.53 ? -18 U   B N3    1 
ATOM   6502 C  C4    . U   B 2 18  ? 111.123 152.408 104.189 1.00 72.53 ? -18 U   B C4    1 
ATOM   6503 O  O4    . U   B 2 18  ? 111.730 151.594 103.493 1.00 72.53 ? -18 U   B O4    1 
ATOM   6504 C  C5    . U   B 2 18  ? 110.228 153.413 103.714 1.00 72.53 ? -18 U   B C5    1 
ATOM   6505 C  C6    . U   B 2 18  ? 109.637 154.231 104.589 1.00 72.53 ? -18 U   B C6    1 
ATOM   6506 P  P     . A   B 2 19  ? 107.994 153.692 111.441 1.00 56.23 ? -17 A   B P     1 
ATOM   6507 O  OP1   . A   B 2 19  ? 107.061 154.166 112.493 1.00 56.23 ? -17 A   B OP1   1 
ATOM   6508 O  OP2   . A   B 2 19  ? 109.441 153.597 111.738 1.00 56.23 ? -17 A   B OP2   1 
ATOM   6509 O  "O5'" . A   B 2 19  ? 107.503 152.258 110.955 1.00 56.23 ? -17 A   B "O5'" 1 
ATOM   6510 C  "C5'" . A   B 2 19  ? 106.116 151.951 110.866 1.00 56.23 ? -17 A   B "C5'" 1 
ATOM   6511 C  "C4'" . A   B 2 19  ? 105.835 150.530 111.285 1.00 56.23 ? -17 A   B "C4'" 1 
ATOM   6512 O  "O4'" . A   B 2 19  ? 106.530 149.627 110.384 1.00 56.23 ? -17 A   B "O4'" 1 
ATOM   6513 C  "C3'" . A   B 2 19  ? 106.299 150.167 112.692 1.00 56.23 ? -17 A   B "C3'" 1 
ATOM   6514 O  "O3'" . A   B 2 19  ? 105.408 149.205 113.252 1.00 56.23 ? -17 A   B "O3'" 1 
ATOM   6515 C  "C2'" . A   B 2 19  ? 107.661 149.526 112.443 1.00 56.23 ? -17 A   B "C2'" 1 
ATOM   6516 O  "O2'" . A   B 2 19  ? 108.083 148.628 113.446 1.00 56.23 ? -17 A   B "O2'" 1 
ATOM   6517 C  "C1'" . A   B 2 19  ? 107.432 148.816 111.113 1.00 56.23 ? -17 A   B "C1'" 1 
ATOM   6518 N  N9    . A   B 2 19  ? 108.645 148.667 110.311 1.00 56.23 ? -17 A   B N9    1 
ATOM   6519 C  C8    . A   B 2 19  ? 109.060 149.459 109.271 1.00 56.23 ? -17 A   B C8    1 
ATOM   6520 N  N7    . A   B 2 19  ? 110.189 149.076 108.733 1.00 56.23 ? -17 A   B N7    1 
ATOM   6521 C  C5    . A   B 2 19  ? 110.535 147.953 109.466 1.00 56.23 ? -17 A   B C5    1 
ATOM   6522 C  C6    . A   B 2 19  ? 111.629 147.083 109.391 1.00 56.23 ? -17 A   B C6    1 
ATOM   6523 N  N6    . A   B 2 19  ? 112.613 147.220 108.503 1.00 56.23 ? -17 A   B N6    1 
ATOM   6524 N  N1    . A   B 2 19  ? 111.682 146.059 110.266 1.00 56.23 ? -17 A   B N1    1 
ATOM   6525 C  C2    . A   B 2 19  ? 110.692 145.928 111.154 1.00 56.23 ? -17 A   B C2    1 
ATOM   6526 N  N3    . A   B 2 19  ? 109.610 146.682 111.326 1.00 56.23 ? -17 A   B N3    1 
ATOM   6527 C  C4    . A   B 2 19  ? 109.591 147.684 110.436 1.00 56.23 ? -17 A   B C4    1 
ATOM   6528 P  P     . G   B 2 20  ? 104.703 149.480 114.669 1.00 54.80 ? -16 G   B P     1 
ATOM   6529 O  OP1   . G   B 2 20  ? 103.247 149.649 114.441 1.00 54.80 ? -16 G   B OP1   1 
ATOM   6530 O  OP2   . G   B 2 20  ? 105.464 150.551 115.356 1.00 54.80 ? -16 G   B OP2   1 
ATOM   6531 O  "O5'" . G   B 2 20  ? 104.933 148.129 115.480 1.00 54.80 ? -16 G   B "O5'" 1 
ATOM   6532 C  "C5'" . G   B 2 20  ? 104.272 146.930 115.110 1.00 54.80 ? -16 G   B "C5'" 1 
ATOM   6533 C  "C4'" . G   B 2 20  ? 105.107 146.115 114.158 1.00 54.80 ? -16 G   B "C4'" 1 
ATOM   6534 O  "O4'" . G   B 2 20  ? 106.480 146.574 114.192 1.00 54.80 ? -16 G   B "O4'" 1 
ATOM   6535 C  "C3'" . G   B 2 20  ? 105.211 144.632 114.462 1.00 54.80 ? -16 G   B "C3'" 1 
ATOM   6536 O  "O3'" . G   B 2 20  ? 104.083 143.897 114.027 1.00 54.80 ? -16 G   B "O3'" 1 
ATOM   6537 C  "C2'" . G   B 2 20  ? 106.503 144.243 113.760 1.00 54.80 ? -16 G   B "C2'" 1 
ATOM   6538 O  "O2'" . G   B 2 20  ? 106.294 144.110 112.363 1.00 54.80 ? -16 G   B "O2'" 1 
ATOM   6539 C  "C1'" . G   B 2 20  ? 107.356 145.486 113.996 1.00 54.80 ? -16 G   B "C1'" 1 
ATOM   6540 N  N9    . G   B 2 20  ? 108.211 145.357 115.189 1.00 54.80 ? -16 G   B N9    1 
ATOM   6541 C  C8    . G   B 2 20  ? 107.971 145.903 116.425 1.00 54.80 ? -16 G   B C8    1 
ATOM   6542 N  N7    . G   B 2 20  ? 108.903 145.630 117.293 1.00 54.80 ? -16 G   B N7    1 
ATOM   6543 C  C5    . G   B 2 20  ? 109.815 144.861 116.585 1.00 54.80 ? -16 G   B C5    1 
ATOM   6544 C  C6    . G   B 2 20  ? 111.034 144.274 117.001 1.00 54.80 ? -16 G   B C6    1 
ATOM   6545 O  O6    . G   B 2 20  ? 111.571 144.316 118.112 1.00 54.80 ? -16 G   B O6    1 
ATOM   6546 N  N1    . G   B 2 20  ? 111.650 143.576 115.972 1.00 54.80 ? -16 G   B N1    1 
ATOM   6547 C  C2    . G   B 2 20  ? 111.156 143.456 114.701 1.00 54.80 ? -16 G   B C2    1 
ATOM   6548 N  N2    . G   B 2 20  ? 111.905 142.738 113.854 1.00 54.80 ? -16 G   B N2    1 
ATOM   6549 N  N3    . G   B 2 20  ? 110.020 143.999 114.297 1.00 54.80 ? -16 G   B N3    1 
ATOM   6550 C  C4    . G   B 2 20  ? 109.404 144.682 115.284 1.00 54.80 ? -16 G   B C4    1 
ATOM   6551 P  P     . A   B 2 21  ? 103.550 142.650 114.888 1.00 44.80 ? -15 A   B P     1 
ATOM   6552 O  OP1   . A   B 2 21  ? 102.168 142.340 114.440 1.00 44.80 ? -15 A   B OP1   1 
ATOM   6553 O  OP2   . A   B 2 21  ? 103.826 142.921 116.320 1.00 44.80 ? -15 A   B OP2   1 
ATOM   6554 O  "O5'" . A   B 2 21  ? 104.490 141.449 114.442 1.00 44.80 ? -15 A   B "O5'" 1 
ATOM   6555 C  "C5'" . A   B 2 21  ? 104.576 141.065 113.081 1.00 44.80 ? -15 A   B "C5'" 1 
ATOM   6556 C  "C4'" . A   B 2 21  ? 105.797 140.222 112.830 1.00 44.80 ? -15 A   B "C4'" 1 
ATOM   6557 O  "O4'" . A   B 2 21  ? 106.992 141.011 113.052 1.00 44.80 ? -15 A   B "O4'" 1 
ATOM   6558 C  "C3'" . A   B 2 21  ? 105.969 139.029 113.748 1.00 44.80 ? -15 A   B "C3'" 1 
ATOM   6559 O  "O3'" . A   B 2 21  ? 105.181 137.922 113.355 1.00 44.80 ? -15 A   B "O3'" 1 
ATOM   6560 C  "C2'" . A   B 2 21  ? 107.467 138.773 113.687 1.00 44.80 ? -15 A   B "C2'" 1 
ATOM   6561 O  "O2'" . A   B 2 21  ? 107.805 138.074 112.502 1.00 44.80 ? -15 A   B "O2'" 1 
ATOM   6562 C  "C1'" . A   B 2 21  ? 108.014 140.198 113.584 1.00 44.80 ? -15 A   B "C1'" 1 
ATOM   6563 N  N9    . A   B 2 21  ? 108.411 140.747 114.895 1.00 44.80 ? -15 A   B N9    1 
ATOM   6564 C  C8    . A   B 2 21  ? 107.734 141.668 115.649 1.00 44.80 ? -15 A   B C8    1 
ATOM   6565 N  N7    . A   B 2 21  ? 108.330 141.974 116.774 1.00 44.80 ? -15 A   B N7    1 
ATOM   6566 C  C5    . A   B 2 21  ? 109.482 141.206 116.760 1.00 44.80 ? -15 A   B C5    1 
ATOM   6567 C  C6    . A   B 2 21  ? 110.540 141.075 117.674 1.00 44.80 ? -15 A   B C6    1 
ATOM   6568 N  N6    . A   B 2 21  ? 110.613 141.744 118.825 1.00 44.80 ? -15 A   B N6    1 
ATOM   6569 N  N1    . A   B 2 21  ? 111.536 140.221 117.365 1.00 44.80 ? -15 A   B N1    1 
ATOM   6570 C  C2    . A   B 2 21  ? 111.465 139.550 116.211 1.00 44.80 ? -15 A   B C2    1 
ATOM   6571 N  N3    . A   B 2 21  ? 110.523 139.589 115.274 1.00 44.80 ? -15 A   B N3    1 
ATOM   6572 C  C4    . A   B 2 21  ? 109.546 140.446 115.611 1.00 44.80 ? -15 A   B C4    1 
ATOM   6573 P  P     . G   B 2 22  ? 105.070 136.632 114.302 1.00 43.42 ? -14 G   B P     1 
ATOM   6574 O  OP1   . G   B 2 22  ? 103.902 135.832 113.875 1.00 43.42 ? -14 G   B OP1   1 
ATOM   6575 O  OP2   . G   B 2 22  ? 105.154 137.081 115.710 1.00 43.42 ? -14 G   B OP2   1 
ATOM   6576 O  "O5'" . G   B 2 22  ? 106.376 135.800 113.946 1.00 43.42 ? -14 G   B "O5'" 1 
ATOM   6577 C  "C5'" . G   B 2 22  ? 106.696 134.621 114.656 1.00 43.42 ? -14 G   B "C5'" 1 
ATOM   6578 C  "C4'" . G   B 2 22  ? 108.173 134.537 114.936 1.00 43.42 ? -14 G   B "C4'" 1 
ATOM   6579 O  "O4'" . G   B 2 22  ? 108.740 135.868 115.029 1.00 43.42 ? -14 G   B "O4'" 1 
ATOM   6580 C  "C3'" . G   B 2 22  ? 108.549 133.888 116.254 1.00 43.42 ? -14 G   B "C3'" 1 
ATOM   6581 O  "O3'" . G   B 2 22  ? 108.503 132.476 116.207 1.00 43.42 ? -14 G   B "O3'" 1 
ATOM   6582 C  "C2'" . G   B 2 22  ? 109.932 134.458 116.522 1.00 43.42 ? -14 G   B "C2'" 1 
ATOM   6583 O  "O2'" . G   B 2 22  ? 110.906 133.796 115.733 1.00 43.42 ? -14 G   B "O2'" 1 
ATOM   6584 C  "C1'" . G   B 2 22  ? 109.771 135.884 115.995 1.00 43.42 ? -14 G   B "C1'" 1 
ATOM   6585 N  N9    . G   B 2 22  ? 109.400 136.831 117.062 1.00 43.42 ? -14 G   B N9    1 
ATOM   6586 C  C8    . G   B 2 22  ? 108.276 137.614 117.117 1.00 43.42 ? -14 G   B C8    1 
ATOM   6587 N  N7    . G   B 2 22  ? 108.214 138.358 118.184 1.00 43.42 ? -14 G   B N7    1 
ATOM   6588 C  C5    . G   B 2 22  ? 109.374 138.051 118.877 1.00 43.42 ? -14 G   B C5    1 
ATOM   6589 C  C6    . G   B 2 22  ? 109.863 138.542 120.113 1.00 43.42 ? -14 G   B C6    1 
ATOM   6590 O  O6    . G   B 2 22  ? 109.351 139.375 120.869 1.00 43.42 ? -14 G   B O6    1 
ATOM   6591 N  N1    . G   B 2 22  ? 111.077 137.961 120.451 1.00 43.42 ? -14 G   B N1    1 
ATOM   6592 C  C2    . G   B 2 22  ? 111.738 137.028 119.701 1.00 43.42 ? -14 G   B C2    1 
ATOM   6593 N  N2    . G   B 2 22  ? 112.901 136.584 120.194 1.00 43.42 ? -14 G   B N2    1 
ATOM   6594 N  N3    . G   B 2 22  ? 111.296 136.564 118.549 1.00 43.42 ? -14 G   B N3    1 
ATOM   6595 C  C4    . G   B 2 22  ? 110.117 137.114 118.198 1.00 43.42 ? -14 G   B C4    1 
ATOM   6596 P  P     . G   B 2 23  ? 107.809 131.665 117.402 1.00 48.81 ? -13 G   B P     1 
ATOM   6597 O  OP1   . G   B 2 23  ? 107.464 130.311 116.907 1.00 48.81 ? -13 G   B OP1   1 
ATOM   6598 O  OP2   . G   B 2 23  ? 106.761 132.525 118.000 1.00 48.81 ? -13 G   B OP2   1 
ATOM   6599 O  "O5'" . G   B 2 23  ? 108.981 131.505 118.460 1.00 48.81 ? -13 G   B "O5'" 1 
ATOM   6600 C  "C5'" . G   B 2 23  ? 110.234 130.975 118.061 1.00 48.81 ? -13 G   B "C5'" 1 
ATOM   6601 C  "C4'" . G   B 2 23  ? 111.275 131.147 119.134 1.00 48.81 ? -13 G   B "C4'" 1 
ATOM   6602 O  "O4'" . G   B 2 23  ? 111.613 132.549 119.283 1.00 48.81 ? -13 G   B "O4'" 1 
ATOM   6603 C  "C3'" . G   B 2 23  ? 110.866 130.727 120.531 1.00 48.81 ? -13 G   B "C3'" 1 
ATOM   6604 O  "O3'" . G   B 2 23  ? 110.916 129.327 120.728 1.00 48.81 ? -13 G   B "O3'" 1 
ATOM   6605 C  "C2'" . G   B 2 23  ? 111.840 131.506 121.398 1.00 48.81 ? -13 G   B "C2'" 1 
ATOM   6606 O  "O2'" . G   B 2 23  ? 113.121 130.897 121.377 1.00 48.81 ? -13 G   B "O2'" 1 
ATOM   6607 C  "C1'" . G   B 2 23  ? 111.924 132.822 120.631 1.00 48.81 ? -13 G   B "C1'" 1 
ATOM   6608 N  N9    . G   B 2 23  ? 110.961 133.807 121.146 1.00 48.81 ? -13 G   B N9    1 
ATOM   6609 C  C8    . G   B 2 23  ? 109.802 134.236 120.556 1.00 48.81 ? -13 G   B C8    1 
ATOM   6610 N  N7    . G   B 2 23  ? 109.163 135.116 121.273 1.00 48.81 ? -13 G   B N7    1 
ATOM   6611 C  C5    . G   B 2 23  ? 109.948 135.275 122.402 1.00 48.81 ? -13 G   B C5    1 
ATOM   6612 C  C6    . G   B 2 23  ? 109.770 136.097 123.539 1.00 48.81 ? -13 G   B C6    1 
ATOM   6613 O  O6    . G   B 2 23  ? 108.846 136.881 123.781 1.00 48.81 ? -13 G   B O6    1 
ATOM   6614 N  N1    . G   B 2 23  ? 110.809 135.943 124.449 1.00 48.81 ? -13 G   B N1    1 
ATOM   6615 C  C2    . G   B 2 23  ? 111.882 135.103 124.288 1.00 48.81 ? -13 G   B C2    1 
ATOM   6616 N  N2    . G   B 2 23  ? 112.789 135.088 125.273 1.00 48.81 ? -13 G   B N2    1 
ATOM   6617 N  N3    . G   B 2 23  ? 112.059 134.332 123.235 1.00 48.81 ? -13 G   B N3    1 
ATOM   6618 C  C4    . G   B 2 23  ? 111.060 134.471 122.339 1.00 48.81 ? -13 G   B C4    1 
ATOM   6619 P  P     . G   B 2 24  ? 109.865 128.622 121.715 1.00 51.49 ? -12 G   B P     1 
ATOM   6620 O  OP1   . G   B 2 24  ? 109.994 127.151 121.555 1.00 51.49 ? -12 G   B OP1   1 
ATOM   6621 O  OP2   . G   B 2 24  ? 108.545 129.275 121.528 1.00 51.49 ? -12 G   B OP2   1 
ATOM   6622 O  "O5'" . G   B 2 24  ? 110.394 129.010 123.164 1.00 51.49 ? -12 G   B "O5'" 1 
ATOM   6623 C  "C5'" . G   B 2 24  ? 111.717 128.688 123.564 1.00 51.49 ? -12 G   B "C5'" 1 
ATOM   6624 C  "C4'" . G   B 2 24  ? 112.024 129.236 124.932 1.00 51.49 ? -12 G   B "C4'" 1 
ATOM   6625 O  "O4'" . G   B 2 24  ? 111.994 130.684 124.900 1.00 51.49 ? -12 G   B "O4'" 1 
ATOM   6626 C  "C3'" . G   B 2 24  ? 111.035 128.874 126.023 1.00 51.49 ? -12 G   B "C3'" 1 
ATOM   6627 O  "O3'" . G   B 2 24  ? 111.248 127.577 126.544 1.00 51.49 ? -12 G   B "O3'" 1 
ATOM   6628 C  "C2'" . G   B 2 24  ? 111.240 129.987 127.039 1.00 51.49 ? -12 G   B "C2'" 1 
ATOM   6629 O  "O2'" . G   B 2 24  ? 112.407 129.748 127.810 1.00 51.49 ? -12 G   B "O2'" 1 
ATOM   6630 C  "C1'" . G   B 2 24  ? 111.506 131.183 126.126 1.00 51.49 ? -12 G   B "C1'" 1 
ATOM   6631 N  N9    . G   B 2 24  ? 110.291 131.970 125.858 1.00 51.49 ? -12 G   B N9    1 
ATOM   6632 C  C8    . G   B 2 24  ? 109.430 131.823 124.803 1.00 51.49 ? -12 G   B C8    1 
ATOM   6633 N  N7    . G   B 2 24  ? 108.442 132.675 124.826 1.00 51.49 ? -12 G   B N7    1 
ATOM   6634 C  C5    . G   B 2 24  ? 108.665 133.432 125.965 1.00 51.49 ? -12 G   B C5    1 
ATOM   6635 C  C6    . G   B 2 24  ? 107.925 134.510 126.512 1.00 51.49 ? -12 G   B C6    1 
ATOM   6636 O  O6    . G   B 2 24  ? 106.888 135.030 126.087 1.00 51.49 ? -12 G   B O6    1 
ATOM   6637 N  N1    . G   B 2 24  ? 108.509 134.985 127.679 1.00 51.49 ? -12 G   B N1    1 
ATOM   6638 C  C2    . G   B 2 24  ? 109.655 134.488 128.244 1.00 51.49 ? -12 G   B C2    1 
ATOM   6639 N  N2    . G   B 2 24  ? 110.061 135.082 129.373 1.00 51.49 ? -12 G   B N2    1 
ATOM   6640 N  N3    . G   B 2 24  ? 110.354 133.485 127.746 1.00 51.49 ? -12 G   B N3    1 
ATOM   6641 C  C4    . G   B 2 24  ? 109.804 133.008 126.613 1.00 51.49 ? -12 G   B C4    1 
ATOM   6642 P  P     . A   B 2 25  ? 110.094 126.855 127.392 1.00 57.43 ? -11 A   B P     1 
ATOM   6643 O  OP1   . A   B 2 25  ? 110.340 125.392 127.352 1.00 57.43 ? -11 A   B OP1   1 
ATOM   6644 O  OP2   . A   B 2 25  ? 108.788 127.395 126.936 1.00 57.43 ? -11 A   B OP2   1 
ATOM   6645 O  "O5'" . A   B 2 25  ? 110.347 127.365 128.878 1.00 57.43 ? -11 A   B "O5'" 1 
ATOM   6646 C  "C5'" . A   B 2 25  ? 109.357 127.213 129.881 1.00 57.43 ? -11 A   B "C5'" 1 
ATOM   6647 C  "C4'" . A   B 2 25  ? 109.501 128.263 130.950 1.00 57.43 ? -11 A   B "C4'" 1 
ATOM   6648 O  "O4'" . A   B 2 25  ? 109.809 129.541 130.334 1.00 57.43 ? -11 A   B "O4'" 1 
ATOM   6649 C  "C3'" . A   B 2 25  ? 108.257 128.546 131.775 1.00 57.43 ? -11 A   B "C3'" 1 
ATOM   6650 O  "O3'" . A   B 2 25  ? 108.033 127.606 132.809 1.00 57.43 ? -11 A   B "O3'" 1 
ATOM   6651 C  "C2'" . A   B 2 25  ? 108.510 129.961 132.265 1.00 57.43 ? -11 A   B "C2'" 1 
ATOM   6652 O  "O2'" . A   B 2 25  ? 109.467 129.965 133.313 1.00 57.43 ? -11 A   B "O2'" 1 
ATOM   6653 C  "C1'" . A   B 2 25  ? 109.152 130.579 131.028 1.00 57.43 ? -11 A   B "C1'" 1 
ATOM   6654 N  N9    . A   B 2 25  ? 108.129 131.141 130.134 1.00 57.43 ? -11 A   B N9    1 
ATOM   6655 C  C8    . A   B 2 25  ? 107.710 130.657 128.923 1.00 57.43 ? -11 A   B C8    1 
ATOM   6656 N  N7    . A   B 2 25  ? 106.768 131.376 128.369 1.00 57.43 ? -11 A   B N7    1 
ATOM   6657 C  C5    . A   B 2 25  ? 106.553 132.396 129.283 1.00 57.43 ? -11 A   B C5    1 
ATOM   6658 C  C6    . A   B 2 25  ? 105.678 133.491 129.291 1.00 57.43 ? -11 A   B C6    1 
ATOM   6659 N  N6    . A   B 2 25  ? 104.817 133.762 128.311 1.00 57.43 ? -11 A   B N6    1 
ATOM   6660 N  N1    . A   B 2 25  ? 105.716 134.316 130.357 1.00 57.43 ? -11 A   B N1    1 
ATOM   6661 C  C2    . A   B 2 25  ? 106.579 134.053 131.343 1.00 57.43 ? -11 A   B C2    1 
ATOM   6662 N  N3    . A   B 2 25  ? 107.450 133.056 131.451 1.00 57.43 ? -11 A   B N3    1 
ATOM   6663 C  C4    . A   B 2 25  ? 107.383 132.259 130.375 1.00 57.43 ? -11 A   B C4    1 
ATOM   6664 P  P     . G   B 2 26  ? 106.592 126.910 132.951 1.00 60.62 ? -10 G   B P     1 
ATOM   6665 O  OP1   . G   B 2 26  ? 106.690 125.870 134.004 1.00 60.62 ? -10 G   B OP1   1 
ATOM   6666 O  OP2   . G   B 2 26  ? 106.123 126.542 131.591 1.00 60.62 ? -10 G   B OP2   1 
ATOM   6667 O  "O5'" . G   B 2 26  ? 105.651 128.074 133.492 1.00 60.62 ? -10 G   B "O5'" 1 
ATOM   6668 C  "C5'" . G   B 2 26  ? 105.802 128.569 134.812 1.00 60.62 ? -10 G   B "C5'" 1 
ATOM   6669 C  "C4'" . G   B 2 26  ? 105.006 129.830 135.038 1.00 60.62 ? -10 G   B "C4'" 1 
ATOM   6670 O  "O4'" . G   B 2 26  ? 105.342 130.816 134.028 1.00 60.62 ? -10 G   B "O4'" 1 
ATOM   6671 C  "C3'" . G   B 2 26  ? 103.495 129.709 134.932 1.00 60.62 ? -10 G   B "C3'" 1 
ATOM   6672 O  "O3'" . G   B 2 26  ? 102.889 129.153 136.085 1.00 60.62 ? -10 G   B "O3'" 1 
ATOM   6673 C  "C2'" . G   B 2 26  ? 103.078 131.145 134.654 1.00 60.62 ? -10 G   B "C2'" 1 
ATOM   6674 O  "O2'" . G   B 2 26  ? 103.129 131.921 135.842 1.00 60.62 ? -10 G   B "O2'" 1 
ATOM   6675 C  "C1'" . G   B 2 26  ? 104.207 131.604 133.734 1.00 60.62 ? -10 G   B "C1'" 1 
ATOM   6676 N  N9    . G   B 2 26  ? 103.852 131.416 132.317 1.00 60.62 ? -10 G   B N9    1 
ATOM   6677 C  C8    . G   B 2 26  ? 104.264 130.419 131.469 1.00 60.62 ? -10 G   B C8    1 
ATOM   6678 N  N7    . G   B 2 26  ? 103.758 130.532 130.272 1.00 60.62 ? -10 G   B N7    1 
ATOM   6679 C  C5    . G   B 2 26  ? 102.963 131.668 130.339 1.00 60.62 ? -10 G   B C5    1 
ATOM   6680 C  C6    . G   B 2 26  ? 102.162 132.293 129.352 1.00 60.62 ? -10 G   B C6    1 
ATOM   6681 O  O6    . G   B 2 26  ? 101.986 131.959 128.176 1.00 60.62 ? -10 G   B O6    1 
ATOM   6682 N  N1    . G   B 2 26  ? 101.524 133.420 129.852 1.00 60.62 ? -10 G   B N1    1 
ATOM   6683 C  C2    . G   B 2 26  ? 101.640 133.886 131.135 1.00 60.62 ? -10 G   B C2    1 
ATOM   6684 N  N2    . G   B 2 26  ? 100.943 134.991 131.430 1.00 60.62 ? -10 G   B N2    1 
ATOM   6685 N  N3    . G   B 2 26  ? 102.383 133.316 132.063 1.00 60.62 ? -10 G   B N3    1 
ATOM   6686 C  C4    . G   B 2 26  ? 103.010 132.221 131.596 1.00 60.62 ? -10 G   B C4    1 
ATOM   6687 P  P     . G   B 2 27  ? 101.469 128.411 135.966 1.00 53.28 ? -9  G   B P     1 
ATOM   6688 O  OP1   . G   B 2 27  ? 101.219 127.675 137.228 1.00 53.28 ? -9  G   B OP1   1 
ATOM   6689 O  OP2   . G   B 2 27  ? 101.442 127.674 134.679 1.00 53.28 ? -9  G   B OP2   1 
ATOM   6690 O  "O5'" . G   B 2 27  ? 100.418 129.605 135.873 1.00 53.28 ? -9  G   B "O5'" 1 
ATOM   6691 C  "C5'" . G   B 2 27  ? 100.232 130.497 136.962 1.00 53.28 ? -9  G   B "C5'" 1 
ATOM   6692 C  "C4'" . G   B 2 27  ? 99.390  131.684 136.568 1.00 53.28 ? -9  G   B "C4'" 1 
ATOM   6693 O  "O4'" . G   B 2 27  ? 99.988  132.346 135.424 1.00 53.28 ? -9  G   B "O4'" 1 
ATOM   6694 C  "C3'" . G   B 2 27  ? 97.970  131.378 136.117 1.00 53.28 ? -9  G   B "C3'" 1 
ATOM   6695 O  "O3'" . G   B 2 27  ? 97.072  131.197 137.197 1.00 53.28 ? -9  G   B "O3'" 1 
ATOM   6696 C  "C2'" . G   B 2 27  ? 97.636  132.579 135.244 1.00 53.28 ? -9  G   B "C2'" 1 
ATOM   6697 O  "O2'" . G   B 2 27  ? 97.319  133.706 136.045 1.00 53.28 ? -9  G   B "O2'" 1 
ATOM   6698 C  "C1'" . G   B 2 27  ? 98.980  132.837 134.568 1.00 53.28 ? -9  G   B "C1'" 1 
ATOM   6699 N  N9    . G   B 2 27  ? 99.089  132.135 133.276 1.00 53.28 ? -9  G   B N9    1 
ATOM   6700 C  C8    . G   B 2 27  ? 99.883  131.052 132.992 1.00 53.28 ? -9  G   B C8    1 
ATOM   6701 N  N7    . G   B 2 27  ? 99.771  130.643 131.760 1.00 53.28 ? -9  G   B N7    1 
ATOM   6702 C  C5    . G   B 2 27  ? 98.847  131.509 131.199 1.00 53.28 ? -9  G   B C5    1 
ATOM   6703 C  C6    . G   B 2 27  ? 98.325  131.558 129.887 1.00 53.28 ? -9  G   B C6    1 
ATOM   6704 O  O6    . G   B 2 27  ? 98.586  130.822 128.930 1.00 53.28 ? -9  G   B O6    1 
ATOM   6705 N  N1    . G   B 2 27  ? 97.410  132.592 129.740 1.00 53.28 ? -9  G   B N1    1 
ATOM   6706 C  C2    . G   B 2 27  ? 97.046  133.467 130.729 1.00 53.28 ? -9  G   B C2    1 
ATOM   6707 N  N2    . G   B 2 27  ? 96.146  134.398 130.390 1.00 53.28 ? -9  G   B N2    1 
ATOM   6708 N  N3    . G   B 2 27  ? 97.526  133.434 131.958 1.00 53.28 ? -9  G   B N3    1 
ATOM   6709 C  C4    . G   B 2 27  ? 98.416  132.436 132.119 1.00 53.28 ? -9  G   B C4    1 
ATOM   6710 P  P     . U   B 2 28  ? 95.987  130.011 137.165 1.00 48.10 ? -8  U   B P     1 
ATOM   6711 O  OP1   . U   B 2 28  ? 95.330  129.966 138.494 1.00 48.10 ? -8  U   B OP1   1 
ATOM   6712 O  OP2   . U   B 2 28  ? 96.641  128.789 136.635 1.00 48.10 ? -8  U   B OP2   1 
ATOM   6713 O  "O5'" . U   B 2 28  ? 94.903  130.501 136.106 1.00 48.10 ? -8  U   B "O5'" 1 
ATOM   6714 C  "C5'" . U   B 2 28  ? 94.088  131.634 136.369 1.00 48.10 ? -8  U   B "C5'" 1 
ATOM   6715 C  "C4'" . U   B 2 28  ? 93.453  132.165 135.109 1.00 48.10 ? -8  U   B "C4'" 1 
ATOM   6716 O  "O4'" . U   B 2 28  ? 94.479  132.384 134.106 1.00 48.10 ? -8  U   B "O4'" 1 
ATOM   6717 C  "C3'" . U   B 2 28  ? 92.455  131.246 134.421 1.00 48.10 ? -8  U   B "C3'" 1 
ATOM   6718 O  "O3'" . U   B 2 28  ? 91.163  131.290 135.002 1.00 48.10 ? -8  U   B "O3'" 1 
ATOM   6719 C  "C2'" . U   B 2 28  ? 92.494  131.734 132.980 1.00 48.10 ? -8  U   B "C2'" 1 
ATOM   6720 O  "O2'" . U   B 2 28  ? 91.737  132.926 132.837 1.00 48.10 ? -8  U   B "O2'" 1 
ATOM   6721 C  "C1'" . U   B 2 28  ? 93.972  132.084 132.823 1.00 48.10 ? -8  U   B "C1'" 1 
ATOM   6722 N  N1    . U   B 2 28  ? 94.760  130.965 132.257 1.00 48.10 ? -8  U   B N1    1 
ATOM   6723 C  C2    . U   B 2 28  ? 94.754  130.803 130.888 1.00 48.10 ? -8  U   B C2    1 
ATOM   6724 O  O2    . U   B 2 28  ? 94.127  131.531 130.141 1.00 48.10 ? -8  U   B O2    1 
ATOM   6725 N  N3    . U   B 2 28  ? 95.509  129.755 130.426 1.00 48.10 ? -8  U   B N3    1 
ATOM   6726 C  C4    . U   B 2 28  ? 96.254  128.873 131.178 1.00 48.10 ? -8  U   B C4    1 
ATOM   6727 O  O4    . U   B 2 28  ? 96.882  127.977 130.618 1.00 48.10 ? -8  U   B O4    1 
ATOM   6728 C  C5    . U   B 2 28  ? 96.212  129.105 132.585 1.00 48.10 ? -8  U   B C5    1 
ATOM   6729 C  C6    . U   B 2 28  ? 95.486  130.118 133.061 1.00 48.10 ? -8  U   B C6    1 
ATOM   6730 P  P     . C   B 2 29  ? 90.236  129.976 135.016 1.00 38.08 ? -7  C   B P     1 
ATOM   6731 O  OP1   . C   B 2 29  ? 89.178  130.178 136.037 1.00 38.08 ? -7  C   B OP1   1 
ATOM   6732 O  OP2   . C   B 2 29  ? 91.113  128.781 135.092 1.00 38.08 ? -7  C   B OP2   1 
ATOM   6733 O  "O5'" . C   B 2 29  ? 89.540  129.977 133.584 1.00 38.08 ? -7  C   B "O5'" 1 
ATOM   6734 C  "C5'" . C   B 2 29  ? 88.635  131.005 133.213 1.00 38.08 ? -7  C   B "C5'" 1 
ATOM   6735 C  "C4'" . C   B 2 29  ? 88.397  131.029 131.724 1.00 38.08 ? -7  C   B "C4'" 1 
ATOM   6736 O  "O4'" . C   B 2 29  ? 89.664  131.132 131.025 1.00 38.08 ? -7  C   B "O4'" 1 
ATOM   6737 C  "C3'" . C   B 2 29  ? 87.750  129.793 131.121 1.00 38.08 ? -7  C   B "C3'" 1 
ATOM   6738 O  "O3'" . C   B 2 29  ? 86.343  129.755 131.299 1.00 38.08 ? -7  C   B "O3'" 1 
ATOM   6739 C  "C2'" . C   B 2 29  ? 88.175  129.880 129.662 1.00 38.08 ? -7  C   B "C2'" 1 
ATOM   6740 O  "O2'" . C   B 2 29  ? 87.375  130.824 128.966 1.00 38.08 ? -7  C   B "O2'" 1 
ATOM   6741 C  "C1'" . C   B 2 29  ? 89.588  130.449 129.791 1.00 38.08 ? -7  C   B "C1'" 1 
ATOM   6742 N  N1    . C   B 2 29  ? 90.630  129.397 129.758 1.00 38.08 ? -7  C   B N1    1 
ATOM   6743 C  C2    . C   B 2 29  ? 91.048  128.900 128.523 1.00 38.08 ? -7  C   B C2    1 
ATOM   6744 O  O2    . C   B 2 29  ? 90.530  129.347 127.492 1.00 38.08 ? -7  C   B O2    1 
ATOM   6745 N  N3    . C   B 2 29  ? 92.000  127.946 128.471 1.00 38.08 ? -7  C   B N3    1 
ATOM   6746 C  C4    . C   B 2 29  ? 92.537  127.485 129.595 1.00 38.08 ? -7  C   B C4    1 
ATOM   6747 N  N4    . C   B 2 29  ? 93.474  126.541 129.503 1.00 38.08 ? -7  C   B N4    1 
ATOM   6748 C  C5    . C   B 2 29  ? 92.134  127.971 130.869 1.00 38.08 ? -7  C   B C5    1 
ATOM   6749 C  C6    . C   B 2 29  ? 91.190  128.919 130.904 1.00 38.08 ? -7  C   B C6    1 
ATOM   6750 P  P     . A   B 2 30  ? 85.528  128.396 131.026 1.00 33.16 ? -6  A   B P     1 
ATOM   6751 O  OP1   . A   B 2 30  ? 84.194  128.536 131.660 1.00 33.16 ? -6  A   B OP1   1 
ATOM   6752 O  OP2   . A   B 2 30  ? 86.394  127.246 131.395 1.00 33.16 ? -6  A   B OP2   1 
ATOM   6753 O  "O5'" . A   B 2 30  ? 85.321  128.378 129.445 1.00 33.16 ? -6  A   B "O5'" 1 
ATOM   6754 C  "C5'" . A   B 2 30  ? 85.159  127.157 128.737 1.00 33.16 ? -6  A   B "C5'" 1 
ATOM   6755 C  "C4'" . A   B 2 30  ? 85.662  127.276 127.320 1.00 33.16 ? -6  A   B "C4'" 1 
ATOM   6756 O  "O4'" . A   B 2 30  ? 87.030  127.763 127.331 1.00 33.16 ? -6  A   B "O4'" 1 
ATOM   6757 C  "C3'" . A   B 2 30  ? 85.750  125.987 126.518 1.00 33.16 ? -6  A   B "C3'" 1 
ATOM   6758 O  "O3'" . A   B 2 30  ? 84.511  125.552 125.987 1.00 33.16 ? -6  A   B "O3'" 1 
ATOM   6759 C  "C2'" . A   B 2 30  ? 86.778  126.342 125.457 1.00 33.16 ? -6  A   B "C2'" 1 
ATOM   6760 O  "O2'" . A   B 2 30  ? 86.203  127.189 124.474 1.00 33.16 ? -6  A   B "O2'" 1 
ATOM   6761 C  "C1'" . A   B 2 30  ? 87.759  127.170 126.277 1.00 33.16 ? -6  A   B "C1'" 1 
ATOM   6762 N  N9    . A   B 2 30  ? 88.826  126.332 126.856 1.00 33.16 ? -6  A   B N9    1 
ATOM   6763 C  C8    . A   B 2 30  ? 89.062  126.075 128.180 1.00 33.16 ? -6  A   B C8    1 
ATOM   6764 N  N7    . A   B 2 30  ? 90.091  125.294 128.391 1.00 33.16 ? -6  A   B N7    1 
ATOM   6765 C  C5    . A   B 2 30  ? 90.565  125.013 127.122 1.00 33.16 ? -6  A   B C5    1 
ATOM   6766 C  C6    . A   B 2 30  ? 91.639  124.236 126.665 1.00 33.16 ? -6  A   B C6    1 
ATOM   6767 N  N6    . A   B 2 30  ? 92.466  123.569 127.467 1.00 33.16 ? -6  A   B N6    1 
ATOM   6768 N  N1    . A   B 2 30  ? 91.842  124.162 125.337 1.00 33.16 ? -6  A   B N1    1 
ATOM   6769 C  C2    . A   B 2 30  ? 91.012  124.830 124.531 1.00 33.16 ? -6  A   B C2    1 
ATOM   6770 N  N3    . A   B 2 30  ? 89.970  125.594 124.840 1.00 33.16 ? -6  A   B N3    1 
ATOM   6771 C  C4    . A   B 2 30  ? 89.796  125.646 126.168 1.00 33.16 ? -6  A   B C4    1 
ATOM   6772 P  P     . G   B 2 31  ? 84.211  123.979 125.831 1.00 34.29 ? -5  G   B P     1 
ATOM   6773 O  OP1   . G   B 2 31  ? 82.895  123.837 125.162 1.00 34.29 ? -5  G   B OP1   1 
ATOM   6774 O  OP2   . G   B 2 31  ? 84.456  123.322 127.137 1.00 34.29 ? -5  G   B OP2   1 
ATOM   6775 O  "O5'" . G   B 2 31  ? 85.337  123.452 124.834 1.00 34.29 ? -5  G   B "O5'" 1 
ATOM   6776 C  "C5'" . G   B 2 31  ? 85.336  123.827 123.466 1.00 34.29 ? -5  G   B "C5'" 1 
ATOM   6777 C  "C4'" . G   B 2 31  ? 86.414  123.116 122.688 1.00 34.29 ? -5  G   B "C4'" 1 
ATOM   6778 O  "O4'" . G   B 2 31  ? 87.720  123.422 123.237 1.00 34.29 ? -5  G   B "O4'" 1 
ATOM   6779 C  "C3'" . G   B 2 31  ? 86.363  121.602 122.708 1.00 34.29 ? -5  G   B "C3'" 1 
ATOM   6780 O  "O3'" . G   B 2 31  ? 85.392  121.076 121.820 1.00 34.29 ? -5  G   B "O3'" 1 
ATOM   6781 C  "C2'" . G   B 2 31  ? 87.795  121.217 122.353 1.00 34.29 ? -5  G   B "C2'" 1 
ATOM   6782 O  "O2'" . G   B 2 31  ? 88.015  121.314 120.955 1.00 34.29 ? -5  G   B "O2'" 1 
ATOM   6783 C  "C1'" . G   B 2 31  ? 88.591  122.327 123.036 1.00 34.29 ? -5  G   B "C1'" 1 
ATOM   6784 N  N9    . G   B 2 31  ? 89.158  121.909 124.331 1.00 34.29 ? -5  G   B N9    1 
ATOM   6785 C  C8    . G   B 2 31  ? 88.737  122.285 125.579 1.00 34.29 ? -5  G   B C8    1 
ATOM   6786 N  N7    . G   B 2 31  ? 89.447  121.764 126.539 1.00 34.29 ? -5  G   B N7    1 
ATOM   6787 C  C5    . G   B 2 31  ? 90.400  121.000 125.885 1.00 34.29 ? -5  G   B C5    1 
ATOM   6788 C  C6    . G   B 2 31  ? 91.446  120.202 126.408 1.00 34.29 ? -5  G   B C6    1 
ATOM   6789 O  O6    . G   B 2 31  ? 91.749  120.005 127.587 1.00 34.29 ? -5  G   B O6    1 
ATOM   6790 N  N1    . G   B 2 31  ? 92.180  119.594 125.404 1.00 34.29 ? -5  G   B N1    1 
ATOM   6791 C  C2    . G   B 2 31  ? 91.938  119.734 124.066 1.00 34.29 ? -5  G   B C2    1 
ATOM   6792 N  N2    . G   B 2 31  ? 92.764  119.058 123.259 1.00 34.29 ? -5  G   B N2    1 
ATOM   6793 N  N3    . G   B 2 31  ? 90.966  120.477 123.561 1.00 34.29 ? -5  G   B N3    1 
ATOM   6794 C  C4    . G   B 2 31  ? 90.238  121.079 124.522 1.00 34.29 ? -5  G   B C4    1 
ATOM   6795 P  P     . A   B 2 32  ? 84.449  119.862 122.285 1.00 31.32 ? -4  A   B P     1 
ATOM   6796 O  OP1   . A   B 2 32  ? 83.477  119.598 121.196 1.00 31.32 ? -4  A   B OP1   1 
ATOM   6797 O  OP2   . A   B 2 32  ? 83.954  120.151 123.651 1.00 31.32 ? -4  A   B OP2   1 
ATOM   6798 O  "O5'" . A   B 2 32  ? 85.440  118.621 122.369 1.00 31.32 ? -4  A   B "O5'" 1 
ATOM   6799 C  "C5'" . A   B 2 32  ? 86.120  118.172 121.210 1.00 31.32 ? -4  A   B "C5'" 1 
ATOM   6800 C  "C4'" . A   B 2 32  ? 87.358  117.391 121.559 1.00 31.32 ? -4  A   B "C4'" 1 
ATOM   6801 O  "O4'" . A   B 2 32  ? 88.210  118.170 122.432 1.00 31.32 ? -4  A   B "O4'" 1 
ATOM   6802 C  "C3'" . A   B 2 32  ? 87.136  116.103 122.323 1.00 31.32 ? -4  A   B "C3'" 1 
ATOM   6803 O  "O3'" . A   B 2 32  ? 86.737  115.040 121.480 1.00 31.32 ? -4  A   B "O3'" 1 
ATOM   6804 C  "C2'" . A   B 2 32  ? 88.488  115.884 122.989 1.00 31.32 ? -4  A   B "C2'" 1 
ATOM   6805 O  "O2'" . A   B 2 32  ? 89.427  115.385 122.051 1.00 31.32 ? -4  A   B "O2'" 1 
ATOM   6806 C  "C1'" . A   B 2 32  ? 88.889  117.317 123.326 1.00 31.32 ? -4  A   B "C1'" 1 
ATOM   6807 N  N9    . A   B 2 32  ? 88.533  117.700 124.705 1.00 31.32 ? -4  A   B N9    1 
ATOM   6808 C  C8    . A   B 2 32  ? 87.463  118.452 125.119 1.00 31.32 ? -4  A   B C8    1 
ATOM   6809 N  N7    . A   B 2 32  ? 87.414  118.645 126.413 1.00 31.32 ? -4  A   B N7    1 
ATOM   6810 C  C5    . A   B 2 32  ? 88.534  117.979 126.882 1.00 31.32 ? -4  A   B C5    1 
ATOM   6811 C  C6    . A   B 2 32  ? 89.050  117.805 128.172 1.00 31.32 ? -4  A   B C6    1 
ATOM   6812 N  N6    . A   B 2 32  ? 88.481  118.307 129.268 1.00 31.32 ? -4  A   B N6    1 
ATOM   6813 N  N1    . A   B 2 32  ? 90.183  117.087 128.302 1.00 31.32 ? -4  A   B N1    1 
ATOM   6814 C  C2    . A   B 2 32  ? 90.752  116.582 127.203 1.00 31.32 ? -4  A   B C2    1 
ATOM   6815 N  N3    . A   B 2 32  ? 90.362  116.677 125.937 1.00 31.32 ? -4  A   B N3    1 
ATOM   6816 C  C4    . A   B 2 32  ? 89.233  117.395 125.844 1.00 31.32 ? -4  A   B C4    1 
ATOM   6817 P  P     . G   B 2 33  ? 85.500  114.101 121.882 1.00 39.46 ? -3  G   B P     1 
ATOM   6818 O  OP1   . G   B 2 33  ? 84.256  114.903 121.838 1.00 39.46 ? -3  G   B OP1   1 
ATOM   6819 O  OP2   . G   B 2 33  ? 85.874  113.386 123.125 1.00 39.46 ? -3  G   B OP2   1 
ATOM   6820 O  "O5'" . G   B 2 33  ? 85.435  113.037 120.701 1.00 39.46 ? -3  G   B "O5'" 1 
ATOM   6821 C  "C5'" . G   B 2 33  ? 85.409  113.451 119.338 1.00 39.46 ? -3  G   B "C5'" 1 
ATOM   6822 C  "C4'" . G   B 2 33  ? 86.465  112.751 118.516 1.00 39.46 ? -3  G   B "C4'" 1 
ATOM   6823 O  "O4'" . G   B 2 33  ? 87.777  113.110 119.024 1.00 39.46 ? -3  G   B "O4'" 1 
ATOM   6824 C  "C3'" . G   B 2 33  ? 86.412  111.228 118.539 1.00 39.46 ? -3  G   B "C3'" 1 
ATOM   6825 O  "O3'" . G   B 2 33  ? 86.921  110.737 117.297 1.00 39.46 ? -3  G   B "O3'" 1 
ATOM   6826 C  "C2'" . G   B 2 33  ? 87.387  110.892 119.657 1.00 39.46 ? -3  G   B "C2'" 1 
ATOM   6827 O  "O2'" . G   B 2 33  ? 87.902  109.581 119.613 1.00 39.46 ? -3  G   B "O2'" 1 
ATOM   6828 C  "C1'" . G   B 2 33  ? 88.465  111.945 119.435 1.00 39.46 ? -3  G   B "C1'" 1 
ATOM   6829 N  N9    . G   B 2 33  ? 89.243  112.276 120.630 1.00 39.46 ? -3  G   B N9    1 
ATOM   6830 C  C8    . G   B 2 33  ? 88.780  112.390 121.917 1.00 39.46 ? -3  G   B C8    1 
ATOM   6831 N  N7    . G   B 2 33  ? 89.715  112.703 122.770 1.00 39.46 ? -3  G   B N7    1 
ATOM   6832 C  C5    . G   B 2 33  ? 90.867  112.800 122.004 1.00 39.46 ? -3  G   B C5    1 
ATOM   6833 C  C6    . G   B 2 33  ? 92.197  113.113 122.377 1.00 39.46 ? -3  G   B C6    1 
ATOM   6834 O  O6    . G   B 2 33  ? 92.642  113.375 123.499 1.00 39.46 ? -3  G   B O6    1 
ATOM   6835 N  N1    . G   B 2 33  ? 93.051  113.105 121.285 1.00 39.46 ? -3  G   B N1    1 
ATOM   6836 C  C2    . G   B 2 33  ? 92.679  112.834 119.997 1.00 39.46 ? -3  G   B C2    1 
ATOM   6837 N  N2    . G   B 2 33  ? 93.651  112.875 119.079 1.00 39.46 ? -3  G   B N2    1 
ATOM   6838 N  N3    . G   B 2 33  ? 91.443  112.542 119.636 1.00 39.46 ? -3  G   B N3    1 
ATOM   6839 C  C4    . G   B 2 33  ? 90.592  112.543 120.682 1.00 39.46 ? -3  G   B C4    1 
ATOM   6840 P  P     . C   B 2 34  ? 86.749  109.197 116.865 1.00 37.71 ? -2  C   B P     1 
ATOM   6841 O  OP1   . C   B 2 34  ? 86.213  109.182 115.484 1.00 37.71 ? -2  C   B OP1   1 
ATOM   6842 O  OP2   . C   B 2 34  ? 86.041  108.463 117.937 1.00 37.71 ? -2  C   B OP2   1 
ATOM   6843 O  "O5'" . C   B 2 34  ? 88.244  108.652 116.807 1.00 37.71 ? -2  C   B "O5'" 1 
ATOM   6844 C  "C5'" . C   B 2 34  ? 89.179  109.219 115.896 1.00 37.71 ? -2  C   B "C5'" 1 
ATOM   6845 C  "C4'" . C   B 2 34  ? 90.573  108.672 116.077 1.00 37.71 ? -2  C   B "C4'" 1 
ATOM   6846 O  "O4'" . C   B 2 34  ? 91.194  109.260 117.254 1.00 37.71 ? -2  C   B "O4'" 1 
ATOM   6847 C  "C3'" . C   B 2 34  ? 90.681  107.157 116.251 1.00 37.71 ? -2  C   B "C3'" 1 
ATOM   6848 O  "O3'" . C   B 2 34  ? 91.870  106.713 115.604 1.00 37.71 ? -2  C   B "O3'" 1 
ATOM   6849 C  "C2'" . C   B 2 34  ? 90.859  107.010 117.757 1.00 37.71 ? -2  C   B "C2'" 1 
ATOM   6850 O  "O2'" . C   B 2 34  ? 91.485  105.812 118.162 1.00 37.71 ? -2  C   B "O2'" 1 
ATOM   6851 C  "C1'" . C   B 2 34  ? 91.713  108.230 118.067 1.00 37.71 ? -2  C   B "C1'" 1 
ATOM   6852 N  N1    . C   B 2 34  ? 91.689  108.658 119.473 1.00 37.71 ? -2  C   B N1    1 
ATOM   6853 C  C2    . C   B 2 34  ? 92.884  109.051 120.075 1.00 37.71 ? -2  C   B C2    1 
ATOM   6854 O  O2    . C   B 2 34  ? 93.923  109.044 119.405 1.00 37.71 ? -2  C   B O2    1 
ATOM   6855 N  N3    . C   B 2 34  ? 92.878  109.440 121.367 1.00 37.71 ? -2  C   B N3    1 
ATOM   6856 C  C4    . C   B 2 34  ? 91.743  109.436 122.059 1.00 37.71 ? -2  C   B C4    1 
ATOM   6857 N  N4    . C   B 2 34  ? 91.786  109.828 123.331 1.00 37.71 ? -2  C   B N4    1 
ATOM   6858 C  C5    . C   B 2 34  ? 90.512  109.036 121.476 1.00 37.71 ? -2  C   B C5    1 
ATOM   6859 C  C6    . C   B 2 34  ? 90.538  108.650 120.197 1.00 37.71 ? -2  C   B C6    1 
ATOM   6860 P  P     . A   B 2 35  ? 91.916  105.305 114.841 1.00 35.85 ? -1  A   B P     1 
ATOM   6861 O  OP1   . A   B 2 35  ? 91.557  105.539 113.424 1.00 35.85 ? -1  A   B OP1   1 
ATOM   6862 O  OP2   . A   B 2 35  ? 91.150  104.321 115.638 1.00 35.85 ? -1  A   B OP2   1 
ATOM   6863 O  "O5'" . A   B 2 35  ? 93.453  104.899 114.902 1.00 35.85 ? -1  A   B "O5'" 1 
ATOM   6864 C  "C5'" . A   B 2 35  ? 93.992  104.261 116.048 1.00 35.85 ? -1  A   B "C5'" 1 
ATOM   6865 C  "C4'" . A   B 2 35  ? 95.370  104.773 116.378 1.00 35.85 ? -1  A   B "C4'" 1 
ATOM   6866 O  "O4'" . A   B 2 35  ? 95.257  106.020 117.107 1.00 35.85 ? -1  A   B "O4'" 1 
ATOM   6867 C  "C3'" . A   B 2 35  ? 96.201  103.887 117.290 1.00 35.85 ? -1  A   B "C3'" 1 
ATOM   6868 O  "O3'" . A   B 2 35  ? 96.852  102.842 116.594 1.00 35.85 ? -1  A   B "O3'" 1 
ATOM   6869 C  "C2'" . A   B 2 35  ? 97.161  104.873 117.937 1.00 35.85 ? -1  A   B "C2'" 1 
ATOM   6870 O  "O2'" . A   B 2 35  ? 98.230  105.181 117.058 1.00 35.85 ? -1  A   B "O2'" 1 
ATOM   6871 C  "C1'" . A   B 2 35  ? 96.283  106.112 118.070 1.00 35.85 ? -1  A   B "C1'" 1 
ATOM   6872 N  N9    . A   B 2 35  ? 95.670  106.234 119.407 1.00 35.85 ? -1  A   B N9    1 
ATOM   6873 C  C8    . A   B 2 35  ? 94.344  106.131 119.729 1.00 35.85 ? -1  A   B C8    1 
ATOM   6874 N  N7    . A   B 2 35  ? 94.096  106.304 121.001 1.00 35.85 ? -1  A   B N7    1 
ATOM   6875 C  C5    . A   B 2 35  ? 95.342  106.540 121.559 1.00 35.85 ? -1  A   B C5    1 
ATOM   6876 C  C6    . A   B 2 35  ? 95.760  106.796 122.876 1.00 35.85 ? -1  A   B C6    1 
ATOM   6877 N  N6    . A   B 2 35  ? 94.934  106.862 123.919 1.00 35.85 ? -1  A   B N6    1 
ATOM   6878 N  N1    . A   B 2 35  ? 97.076  106.984 123.092 1.00 35.85 ? -1  A   B N1    1 
ATOM   6879 C  C2    . A   B 2 35  ? 97.911  106.921 122.053 1.00 35.85 ? -1  A   B C2    1 
ATOM   6880 N  N3    . A   B 2 35  ? 97.639  106.690 120.774 1.00 35.85 ? -1  A   B N3    1 
ATOM   6881 C  C4    . A   B 2 35  ? 96.321  106.503 120.588 1.00 35.85 ? -1  A   B C4    1 
ATOM   6882 P  P     . C   B 2 36  ? 97.162  101.451 117.329 1.00 35.85 ? 0   C   B P     1 
ATOM   6883 O  OP1   . C   B 2 36  ? 97.780  100.536 116.343 1.00 35.85 ? 0   C   B OP1   1 
ATOM   6884 O  OP2   . C   B 2 36  ? 95.944  101.034 118.061 1.00 35.85 ? 0   C   B OP2   1 
ATOM   6885 O  "O5'" . C   B 2 36  ? 98.278  101.819 118.399 1.00 35.85 ? 0   C   B "O5'" 1 
ATOM   6886 C  "C5'" . C   B 2 36  ? 99.602  102.134 117.998 1.00 35.85 ? 0   C   B "C5'" 1 
ATOM   6887 C  "C4'" . C   B 2 36  ? 100.427 102.608 119.165 1.00 35.85 ? 0   C   B "C4'" 1 
ATOM   6888 O  "O4'" . C   B 2 36  ? 99.716  103.659 119.859 1.00 35.85 ? 0   C   B "O4'" 1 
ATOM   6889 C  "C3'" . C   B 2 36  ? 100.709 101.573 120.239 1.00 35.85 ? 0   C   B "C3'" 1 
ATOM   6890 O  "O3'" . C   B 2 36  ? 101.823 100.762 119.916 1.00 35.85 ? 0   C   B "O3'" 1 
ATOM   6891 C  "C2'" . C   B 2 36  ? 100.928 102.423 121.484 1.00 35.85 ? 0   C   B "C2'" 1 
ATOM   6892 O  "O2'" . C   B 2 36  ? 102.250 102.933 121.512 1.00 35.85 ? 0   C   B "O2'" 1 
ATOM   6893 C  "C1'" . C   B 2 36  ? 99.972  103.589 121.241 1.00 35.85 ? 0   C   B "C1'" 1 
ATOM   6894 N  N1    . C   B 2 36  ? 98.682  103.454 121.957 1.00 35.85 ? 0   C   B N1    1 
ATOM   6895 C  C2    . C   B 2 36  ? 98.603  103.851 123.291 1.00 35.85 ? 0   C   B C2    1 
ATOM   6896 O  O2    . C   B 2 36  ? 99.622  104.282 123.841 1.00 35.85 ? 0   C   B O2    1 
ATOM   6897 N  N3    . C   B 2 36  ? 97.428  103.753 123.949 1.00 35.85 ? 0   C   B N3    1 
ATOM   6898 C  C4    . C   B 2 36  ? 96.350  103.288 123.324 1.00 35.85 ? 0   C   B C4    1 
ATOM   6899 N  N4    . C   B 2 36  ? 95.211  103.207 124.010 1.00 35.85 ? 0   C   B N4    1 
ATOM   6900 C  C5    . C   B 2 36  ? 96.395  102.882 121.962 1.00 35.85 ? 0   C   B C5    1 
ATOM   6901 C  C6    . C   B 2 36  ? 97.567  102.987 121.326 1.00 35.85 ? 0   C   B C6    1 
ATOM   6902 P  P     . A   B 2 37  ? 101.863 99.320  120.378 1.00 33.39 ? 1   A   B P     1 
ATOM   6903 O  OP1   . A   B 2 37  ? 102.416 98.535  119.329 1.00 33.39 ? 1   A   B OP1   1 
ATOM   6904 O  OP2   . A   B 2 37  ? 100.670 98.994  121.034 1.00 33.39 ? 1   A   B OP2   1 
ATOM   6905 O  "O5'" . A   B 2 37  ? 103.232 99.118  121.116 1.00 33.39 ? 1   A   B "O5'" 1 
ATOM   6906 C  "C5'" . A   B 2 37  ? 103.492 99.422  122.443 1.00 33.39 ? 1   A   B "C5'" 1 
ATOM   6907 C  "C4'" . A   B 2 37  ? 104.802 100.105 122.447 1.00 33.39 ? 1   A   B "C4'" 1 
ATOM   6908 O  "O4'" . A   B 2 37  ? 105.782 99.101  122.186 1.00 33.39 ? 1   A   B "O4'" 1 
ATOM   6909 C  "C3'" . A   B 2 37  ? 104.990 101.096 121.309 1.00 33.39 ? 1   A   B "C3'" 1 
ATOM   6910 O  "O3'" . A   B 2 37  ? 105.614 102.364 121.504 1.00 33.39 ? 1   A   B "O3'" 1 
ATOM   6911 C  "C2'" . A   B 2 37  ? 105.890 100.300 120.402 1.00 33.39 ? 1   A   B "C2'" 1 
ATOM   6912 O  "O2'" . A   B 2 37  ? 106.820 100.960 119.644 1.00 33.39 ? 1   A   B "O2'" 1 
ATOM   6913 C  "C1'" . A   B 2 37  ? 106.764 99.658  121.419 1.00 33.39 ? 1   A   B "C1'" 1 
ATOM   6914 N  N9    . A   B 2 37  ? 107.576 98.637  120.821 1.00 33.39 ? 1   A   B N9    1 
ATOM   6915 C  C8    . A   B 2 37  ? 107.610 98.400  119.486 1.00 33.39 ? 1   A   B C8    1 
ATOM   6916 N  N7    . A   B 2 37  ? 108.441 97.459  119.138 1.00 33.39 ? 1   A   B N7    1 
ATOM   6917 C  C5    . A   B 2 37  ? 109.032 97.088  120.324 1.00 33.39 ? 1   A   B C5    1 
ATOM   6918 C  C6    . A   B 2 37  ? 110.040 96.185  120.611 1.00 33.39 ? 1   A   B C6    1 
ATOM   6919 N  N6    . A   B 2 37  ? 110.626 95.433  119.688 1.00 33.39 ? 1   A   B N6    1 
ATOM   6920 N  N1    . A   B 2 37  ? 110.419 96.050  121.895 1.00 33.39 ? 1   A   B N1    1 
ATOM   6921 C  C2    . A   B 2 37  ? 109.814 96.797  122.814 1.00 33.39 ? 1   A   B C2    1 
ATOM   6922 N  N3    . A   B 2 37  ? 108.877 97.721  122.655 1.00 33.39 ? 1   A   B N3    1 
ATOM   6923 C  C4    . A   B 2 37  ? 108.520 97.812  121.369 1.00 33.39 ? 1   A   B C4    1 
ATOM   6924 P  P     . U   B 2 38  ? 105.139 103.378 122.545 1.00 40.34 ? 2   U   B P     1 
ATOM   6925 O  OP1   . U   B 2 38  ? 103.788 103.140 122.698 1.00 40.34 ? 2   U   B OP1   1 
ATOM   6926 O  OP2   . U   B 2 38  ? 105.509 104.642 122.147 1.00 40.34 ? 2   U   B OP2   1 
ATOM   6927 O  "O5'" . U   B 2 38  ? 106.260 103.342 123.654 1.00 40.34 ? 2   U   B "O5'" 1 
ATOM   6928 C  "C5'" . U   B 2 38  ? 106.022 103.047 125.032 1.00 40.34 ? 2   U   B "C5'" 1 
ATOM   6929 C  "C4'" . U   B 2 38  ? 107.262 102.571 125.735 1.00 40.34 ? 2   U   B "C4'" 1 
ATOM   6930 O  "O4'" . U   B 2 38  ? 107.828 101.547 124.928 1.00 40.34 ? 2   U   B "O4'" 1 
ATOM   6931 C  "C3'" . U   B 2 38  ? 108.435 103.518 125.846 1.00 40.34 ? 2   U   B "C3'" 1 
ATOM   6932 O  "O3'" . U   B 2 38  ? 108.401 104.402 126.952 1.00 40.34 ? 2   U   B "O3'" 1 
ATOM   6933 C  "C2'" . U   B 2 38  ? 109.574 102.553 126.087 1.00 40.34 ? 2   U   B "C2'" 1 
ATOM   6934 O  "O2'" . U   B 2 38  ? 109.278 101.960 127.308 1.00 40.34 ? 2   U   B "O2'" 1 
ATOM   6935 C  "C1'" . U   B 2 38  ? 109.179 101.375 125.231 1.00 40.34 ? 2   U   B "C1'" 1 
ATOM   6936 N  N1    . U   B 2 38  ? 109.901 101.131 123.982 1.00 40.34 ? 2   U   B N1    1 
ATOM   6937 C  C2    . U   B 2 38  ? 110.888 100.185 124.007 1.00 40.34 ? 2   U   B C2    1 
ATOM   6938 O  O2    . U   B 2 38  ? 111.255 99.653  125.025 1.00 40.34 ? 2   U   B O2    1 
ATOM   6939 N  N3    . U   B 2 38  ? 111.485 99.943  122.804 1.00 40.34 ? 2   U   B N3    1 
ATOM   6940 C  C4    . U   B 2 38  ? 111.176 100.501 121.601 1.00 40.34 ? 2   U   B C4    1 
ATOM   6941 O  O4    . U   B 2 38  ? 111.799 100.163 120.606 1.00 40.34 ? 2   U   B O4    1 
ATOM   6942 C  C5    . U   B 2 38  ? 110.114 101.438 121.644 1.00 40.34 ? 2   U   B C5    1 
ATOM   6943 C  C6    . U   B 2 38  ? 109.525 101.717 122.807 1.00 40.34 ? 2   U   B C6    1 
ATOM   6944 P  P     . A   B 2 39  ? 109.192 105.703 126.953 1.00 48.50 ? 3   A   B P     1 
ATOM   6945 O  OP1   . A   B 2 39  ? 108.501 106.622 127.754 1.00 48.50 ? 3   A   B OP1   1 
ATOM   6946 O  OP2   . A   B 2 39  ? 109.393 106.130 125.605 1.00 48.50 ? 3   A   B OP2   1 
ATOM   6947 O  "O5'" . A   B 2 39  ? 110.556 105.215 127.578 1.00 48.50 ? 3   A   B "O5'" 1 
ATOM   6948 C  "C5'" . A   B 2 39  ? 111.656 105.167 126.662 1.00 48.50 ? 3   A   B "C5'" 1 
ATOM   6949 C  "C4'" . A   B 2 39  ? 112.987 104.738 127.205 1.00 48.50 ? 3   A   B "C4'" 1 
ATOM   6950 O  "O4'" . A   B 2 39  ? 113.286 103.418 126.708 1.00 48.50 ? 3   A   B "O4'" 1 
ATOM   6951 C  "C3'" . A   B 2 39  ? 114.071 105.646 126.655 1.00 48.50 ? 3   A   B "C3'" 1 
ATOM   6952 O  "O3'" . A   B 2 39  ? 114.490 106.664 127.546 1.00 48.50 ? 3   A   B "O3'" 1 
ATOM   6953 C  "C2'" . A   B 2 39  ? 115.125 104.702 126.089 1.00 48.50 ? 3   A   B "C2'" 1 
ATOM   6954 O  "O2'" . A   B 2 39  ? 116.408 104.646 126.641 1.00 48.50 ? 3   A   B "O2'" 1 
ATOM   6955 C  "C1'" . A   B 2 39  ? 114.324 103.455 125.775 1.00 48.50 ? 3   A   B "C1'" 1 
ATOM   6956 N  N9    . A   B 2 39  ? 113.738 103.584 124.451 1.00 48.50 ? 3   A   B N9    1 
ATOM   6957 C  C8    . A   B 2 39  ? 112.643 104.341 124.141 1.00 48.50 ? 3   A   B C8    1 
ATOM   6958 N  N7    . A   B 2 39  ? 112.363 104.367 122.865 1.00 48.50 ? 3   A   B N7    1 
ATOM   6959 C  C5    . A   B 2 39  ? 113.358 103.594 122.292 1.00 48.50 ? 3   A   B C5    1 
ATOM   6960 C  C6    . A   B 2 39  ? 113.626 103.242 120.968 1.00 48.50 ? 3   A   B C6    1 
ATOM   6961 N  N6    . A   B 2 39  ? 112.868 103.614 119.940 1.00 48.50 ? 3   A   B N6    1 
ATOM   6962 N  N1    . A   B 2 39  ? 114.711 102.484 120.729 1.00 48.50 ? 3   A   B N1    1 
ATOM   6963 C  C2    . A   B 2 39  ? 115.475 102.123 121.757 1.00 48.50 ? 3   A   B C2    1 
ATOM   6964 N  N3    . A   B 2 39  ? 115.330 102.396 123.045 1.00 48.50 ? 3   A   B N3    1 
ATOM   6965 C  C4    . A   B 2 39  ? 114.234 103.138 123.251 1.00 48.50 ? 3   A   B C4    1 
ATOM   6966 P  P     . A   B 2 40  ? 114.257 108.186 127.184 1.00 64.20 ? 4   A   B P     1 
ATOM   6967 O  OP1   . A   B 2 40  ? 113.908 108.876 128.391 1.00 64.20 ? 4   A   B OP1   1 
ATOM   6968 O  OP2   . A   B 2 40  ? 113.341 108.283 126.081 1.00 64.20 ? 4   A   B OP2   1 
ATOM   6969 O  "O5'" . A   B 2 40  ? 115.689 108.625 126.668 1.00 64.20 ? 4   A   B "O5'" 1 
ATOM   6970 C  "C5'" . A   B 2 40  ? 116.000 108.651 125.252 1.00 64.20 ? 4   A   B "C5'" 1 
ATOM   6971 C  "C4'" . A   B 2 40  ? 117.358 108.043 124.924 1.00 64.20 ? 4   A   B "C4'" 1 
ATOM   6972 O  "O4'" . A   B 2 40  ? 117.223 106.632 124.609 1.00 64.20 ? 4   A   B "O4'" 1 
ATOM   6973 C  "C3'" . A   B 2 40  ? 118.027 108.650 123.699 1.00 64.20 ? 4   A   B "C3'" 1 
ATOM   6974 O  "O3'" . A   B 2 40  ? 119.116 109.429 124.103 1.00 64.20 ? 4   A   B "O3'" 1 
ATOM   6975 C  "C2'" . A   B 2 40  ? 118.572 107.443 122.966 1.00 64.20 ? 4   A   B "C2'" 1 
ATOM   6976 O  "O2'" . A   B 2 40  ? 119.660 106.894 123.642 1.00 64.20 ? 4   A   B "O2'" 1 
ATOM   6977 C  "C1'" . A   B 2 40  ? 117.491 106.428 123.245 1.00 64.20 ? 4   A   B "C1'" 1 
ATOM   6978 N  N9    . A   B 2 40  ? 116.272 106.676 122.482 1.00 64.20 ? 4   A   B N9    1 
ATOM   6979 C  C8    . A   B 2 40  ? 115.126 107.294 122.904 1.00 64.20 ? 4   A   B C8    1 
ATOM   6980 N  N7    . A   B 2 40  ? 114.197 107.369 121.987 1.00 64.20 ? 4   A   B N7    1 
ATOM   6981 C  C5    . A   B 2 40  ? 114.776 106.776 120.879 1.00 64.20 ? 4   A   B C5    1 
ATOM   6982 C  C6    . A   B 2 40  ? 114.299 106.529 119.588 1.00 64.20 ? 4   A   B C6    1 
ATOM   6983 N  N6    . A   B 2 40  ? 113.088 106.883 119.170 1.00 64.20 ? 4   A   B N6    1 
ATOM   6984 N  N1    . A   B 2 40  ? 115.121 105.905 118.723 1.00 64.20 ? 4   A   B N1    1 
ATOM   6985 C  C2    . A   B 2 40  ? 116.333 105.535 119.148 1.00 64.20 ? 4   A   B C2    1 
ATOM   6986 N  N3    . A   B 2 40  ? 116.894 105.704 120.339 1.00 64.20 ? 4   A   B N3    1 
ATOM   6987 C  C4    . A   B 2 40  ? 116.048 106.329 121.173 1.00 64.20 ? 4   A   B C4    1 
ATOM   6988 P  P     . U   B 2 41  ? 118.994 110.978 124.079 1.00 74.84 ? 5   U   B P     1 
ATOM   6989 O  OP1   . U   B 2 41  ? 120.139 111.524 124.822 1.00 74.84 ? 5   U   B OP1   1 
ATOM   6990 O  OP2   . U   B 2 41  ? 117.640 111.307 124.514 1.00 74.84 ? 5   U   B OP2   1 
ATOM   6991 O  "O5'" . U   B 2 41  ? 119.244 111.312 122.539 1.00 74.84 ? 5   U   B "O5'" 1 
ATOM   6992 C  "C5'" . U   B 2 41  ? 120.432 110.852 121.792 1.00 74.84 ? 5   U   B "C5'" 1 
ATOM   6993 C  "C4'" . U   B 2 41  ? 120.098 109.981 120.588 1.00 74.84 ? 5   U   B "C4'" 1 
ATOM   6994 O  "O4'" . U   B 2 41  ? 118.692 109.984 120.371 1.00 74.84 ? 5   U   B "O4'" 1 
ATOM   6995 C  "C3'" . U   B 2 41  ? 120.633 110.358 119.207 1.00 74.84 ? 5   U   B "C3'" 1 
ATOM   6996 O  "O3'" . U   B 2 41  ? 121.680 109.493 118.795 1.00 74.84 ? 5   U   B "O3'" 1 
ATOM   6997 C  "C2'" . U   B 2 41  ? 119.444 110.135 118.257 1.00 74.84 ? 5   U   B "C2'" 1 
ATOM   6998 O  "O2'" . U   B 2 41  ? 119.661 109.330 117.125 1.00 74.84 ? 5   U   B "O2'" 1 
ATOM   6999 C  "C1'" . U   B 2 41  ? 118.451 109.402 119.142 1.00 74.84 ? 5   U   B "C1'" 1 
ATOM   7000 N  N1    . U   B 2 41  ? 117.041 109.592 118.766 1.00 74.84 ? 5   U   B N1    1 
ATOM   7001 C  C2    . U   B 2 41  ? 116.059 109.819 119.725 1.00 74.84 ? 5   U   B C2    1 
ATOM   7002 O  O2    . U   B 2 41  ? 116.278 109.906 120.918 1.00 74.84 ? 5   U   B O2    1 
ATOM   7003 N  N3    . U   B 2 41  ? 114.797 109.965 119.222 1.00 74.84 ? 5   U   B N3    1 
ATOM   7004 C  C4    . U   B 2 41  ? 114.406 109.880 117.910 1.00 74.84 ? 5   U   B C4    1 
ATOM   7005 O  O4    . U   B 2 41  ? 113.216 110.014 117.626 1.00 74.84 ? 5   U   B O4    1 
ATOM   7006 C  C5    . U   B 2 41  ? 115.465 109.605 116.993 1.00 74.84 ? 5   U   B C5    1 
ATOM   7007 C  C6    . U   B 2 41  ? 116.714 109.474 117.442 1.00 74.84 ? 5   U   B C6    1 
HETATM 7008 MG MG    . MG  C 3 .   ? 101.750 103.927 92.498  1.00 35.94 ? 901 MG  A MG    1 
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