data_8Y76
# 
_entry.id   8Y76 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Y76         pdb_00008y76 10.2210/pdb8y76/pdb 
WWPDB D_1300045127 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Y76 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wangz@bnu.edu.cn 
_pdbx_contact_author.name_first         Zhanxin 
_pdbx_contact_author.name_last          Wang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9956-9376 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Cao, Y.'  1 0000-0001-7804-1118 
'Wang, Z.' 2 0000-0001-9956-9376 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of the SAM domain of L3MBTL3' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cao, Y.'  1 0000-0001-7804-1118 
primary 'Wang, Z.' 2 0000-0001-9956-9376 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Lethal(3)malignant brain tumor-like protein 3' 7829.042 1  ? ? ? ? 
2 water   nat water                                           18.015   55 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'H-l(3)mbt-like protein 3,L(3)mbt-like protein 3,L3mbt-like 3,MBT-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       SVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAE 
_entity_poly.pdbx_seq_one_letter_code_can   SVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAE 
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  SER n 
1 2  VAL n 
1 3  SER n 
1 4  LYS n 
1 5  TRP n 
1 6  SER n 
1 7  THR n 
1 8  ASP n 
1 9  GLU n 
1 10 VAL n 
1 11 SER n 
1 12 GLU n 
1 13 PHE n 
1 14 ILE n 
1 15 GLN n 
1 16 SER n 
1 17 LEU n 
1 18 PRO n 
1 19 GLY n 
1 20 CYS n 
1 21 GLU n 
1 22 GLU n 
1 23 HIS n 
1 24 GLY n 
1 25 LYS n 
1 26 VAL n 
1 27 PHE n 
1 28 LYS n 
1 29 ASP n 
1 30 GLU n 
1 31 GLN n 
1 32 ILE n 
1 33 ASP n 
1 34 GLY n 
1 35 GLU n 
1 36 ALA n 
1 37 PHE n 
1 38 LEU n 
1 39 LEU n 
1 40 MET n 
1 41 THR n 
1 42 GLN n 
1 43 THR n 
1 44 ASP n 
1 45 ILE n 
1 46 VAL n 
1 47 LYS n 
1 48 ILE n 
1 49 MET n 
1 50 SER n 
1 51 ILE n 
1 52 LYS n 
1 53 LEU n 
1 54 GLY n 
1 55 PRO n 
1 56 ALA n 
1 57 LEU n 
1 58 LYS n 
1 59 ILE n 
1 60 PHE n 
1 61 ASN n 
1 62 SER n 
1 63 ILE n 
1 64 LEU n 
1 65 MET n 
1 66 PHE n 
1 67 LYS n 
1 68 ALA n 
1 69 ALA n 
1 70 GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   70 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'L3MBTL3, KIAA1798, MBT1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  SER 1  458 458 SER SER A . n 
A 1 2  VAL 2  459 459 VAL VAL A . n 
A 1 3  SER 3  460 460 SER SER A . n 
A 1 4  LYS 4  461 461 LYS LYS A . n 
A 1 5  TRP 5  462 462 TRP TRP A . n 
A 1 6  SER 6  463 463 SER SER A . n 
A 1 7  THR 7  464 464 THR THR A . n 
A 1 8  ASP 8  465 465 ASP ASP A . n 
A 1 9  GLU 9  466 466 GLU GLU A . n 
A 1 10 VAL 10 467 467 VAL VAL A . n 
A 1 11 SER 11 468 468 SER SER A . n 
A 1 12 GLU 12 469 469 GLU GLU A . n 
A 1 13 PHE 13 470 470 PHE PHE A . n 
A 1 14 ILE 14 471 471 ILE ILE A . n 
A 1 15 GLN 15 472 472 GLN GLN A . n 
A 1 16 SER 16 473 473 SER SER A . n 
A 1 17 LEU 17 474 474 LEU LEU A . n 
A 1 18 PRO 18 475 475 PRO PRO A . n 
A 1 19 GLY 19 476 476 GLY GLY A . n 
A 1 20 CYS 20 477 477 CYS CYS A . n 
A 1 21 GLU 21 478 478 GLU GLU A . n 
A 1 22 GLU 22 479 479 GLU GLU A . n 
A 1 23 HIS 23 480 480 HIS HIS A . n 
A 1 24 GLY 24 481 481 GLY GLY A . n 
A 1 25 LYS 25 482 482 LYS LYS A . n 
A 1 26 VAL 26 483 483 VAL VAL A . n 
A 1 27 PHE 27 484 484 PHE PHE A . n 
A 1 28 LYS 28 485 485 LYS LYS A . n 
A 1 29 ASP 29 486 486 ASP ASP A . n 
A 1 30 GLU 30 487 487 GLU GLU A . n 
A 1 31 GLN 31 488 488 GLN GLN A . n 
A 1 32 ILE 32 489 489 ILE ILE A . n 
A 1 33 ASP 33 490 490 ASP ASP A . n 
A 1 34 GLY 34 491 491 GLY GLY A . n 
A 1 35 GLU 35 492 492 GLU GLU A . n 
A 1 36 ALA 36 493 493 ALA ALA A . n 
A 1 37 PHE 37 494 494 PHE PHE A . n 
A 1 38 LEU 38 495 495 LEU LEU A . n 
A 1 39 LEU 39 496 496 LEU LEU A . n 
A 1 40 MET 40 497 497 MET MET A . n 
A 1 41 THR 41 498 498 THR THR A . n 
A 1 42 GLN 42 499 499 GLN GLN A . n 
A 1 43 THR 43 500 500 THR THR A . n 
A 1 44 ASP 44 501 501 ASP ASP A . n 
A 1 45 ILE 45 502 502 ILE ILE A . n 
A 1 46 VAL 46 503 503 VAL VAL A . n 
A 1 47 LYS 47 504 504 LYS LYS A . n 
A 1 48 ILE 48 505 505 ILE ILE A . n 
A 1 49 MET 49 506 506 MET MET A . n 
A 1 50 SER 50 507 507 SER SER A . n 
A 1 51 ILE 51 508 508 ILE ILE A . n 
A 1 52 LYS 52 509 509 LYS LYS A . n 
A 1 53 LEU 53 510 510 LEU LEU A . n 
A 1 54 GLY 54 511 511 GLY GLY A . n 
A 1 55 PRO 55 512 512 PRO PRO A . n 
A 1 56 ALA 56 513 513 ALA ALA A . n 
A 1 57 LEU 57 514 514 LEU LEU A . n 
A 1 58 LYS 58 515 515 LYS LYS A . n 
A 1 59 ILE 59 516 516 ILE ILE A . n 
A 1 60 PHE 60 517 517 PHE PHE A . n 
A 1 61 ASN 61 518 518 ASN ASN A . n 
A 1 62 SER 62 519 519 SER SER A . n 
A 1 63 ILE 63 520 520 ILE ILE A . n 
A 1 64 LEU 64 521 521 LEU LEU A . n 
A 1 65 MET 65 522 522 MET MET A . n 
A 1 66 PHE 66 523 523 PHE PHE A . n 
A 1 67 LYS 67 524 524 LYS LYS A . n 
A 1 68 ALA 68 525 525 ALA ALA A . n 
A 1 69 ALA 69 526 526 ALA ALA A . n 
A 1 70 GLU 70 527 527 GLU GLU A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1  601 24 HOH HOH A . 
B 2 HOH 2  602 26 HOH HOH A . 
B 2 HOH 3  603 3  HOH HOH A . 
B 2 HOH 4  604 20 HOH HOH A . 
B 2 HOH 5  605 7  HOH HOH A . 
B 2 HOH 6  606 39 HOH HOH A . 
B 2 HOH 7  607 34 HOH HOH A . 
B 2 HOH 8  608 47 HOH HOH A . 
B 2 HOH 9  609 30 HOH HOH A . 
B 2 HOH 10 610 6  HOH HOH A . 
B 2 HOH 11 611 37 HOH HOH A . 
B 2 HOH 12 612 40 HOH HOH A . 
B 2 HOH 13 613 43 HOH HOH A . 
B 2 HOH 14 614 2  HOH HOH A . 
B 2 HOH 15 615 16 HOH HOH A . 
B 2 HOH 16 616 31 HOH HOH A . 
B 2 HOH 17 617 14 HOH HOH A . 
B 2 HOH 18 618 18 HOH HOH A . 
B 2 HOH 19 619 44 HOH HOH A . 
B 2 HOH 20 620 10 HOH HOH A . 
B 2 HOH 21 621 8  HOH HOH A . 
B 2 HOH 22 622 50 HOH HOH A . 
B 2 HOH 23 623 35 HOH HOH A . 
B 2 HOH 24 624 1  HOH HOH A . 
B 2 HOH 25 625 5  HOH HOH A . 
B 2 HOH 26 626 25 HOH HOH A . 
B 2 HOH 27 627 11 HOH HOH A . 
B 2 HOH 28 628 15 HOH HOH A . 
B 2 HOH 29 629 48 HOH HOH A . 
B 2 HOH 30 630 33 HOH HOH A . 
B 2 HOH 31 631 38 HOH HOH A . 
B 2 HOH 32 632 29 HOH HOH A . 
B 2 HOH 33 633 22 HOH HOH A . 
B 2 HOH 34 634 41 HOH HOH A . 
B 2 HOH 35 635 36 HOH HOH A . 
B 2 HOH 36 636 42 HOH HOH A . 
B 2 HOH 37 637 13 HOH HOH A . 
B 2 HOH 38 638 12 HOH HOH A . 
B 2 HOH 39 639 17 HOH HOH A . 
B 2 HOH 40 640 49 HOH HOH A . 
B 2 HOH 41 641 27 HOH HOH A . 
B 2 HOH 42 642 28 HOH HOH A . 
B 2 HOH 43 643 55 HOH HOH A . 
B 2 HOH 44 644 19 HOH HOH A . 
B 2 HOH 45 645 4  HOH HOH A . 
B 2 HOH 46 646 46 HOH HOH A . 
B 2 HOH 47 647 23 HOH HOH A . 
B 2 HOH 48 648 32 HOH HOH A . 
B 2 HOH 49 649 21 HOH HOH A . 
B 2 HOH 50 650 51 HOH HOH A . 
B 2 HOH 51 651 54 HOH HOH A . 
B 2 HOH 52 652 53 HOH HOH A . 
B 2 HOH 53 653 9  HOH HOH A . 
B 2 HOH 54 654 45 HOH HOH A . 
B 2 HOH 55 655 52 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.13_2998 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.13_2998 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .         3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .         4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .         5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Y76 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.820 
_cell.length_a_esd                 ? 
_cell.length_b                     51.820 
_cell.length_b_esd                 ? 
_cell.length_c                     49.834 
_cell.length_c_esd                 ? 
_cell.volume                       115891.397 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Y76 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                170 
_symmetry.space_group_name_Hall            'P 65' 
_symmetry.space_group_name_H-M             'P 65' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Y76 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.14 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.4 M Sodium malonate pH 6.0, 0.1 M MES monohydrate pH 6.0 and 0.5%(w/v) Polyethylene glycol 10000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     80 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-05-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97853 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97853 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          24.13 
_reflns.entry_id                                       8Y76 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.99 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     5315 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          30.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.137 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.99 
_reflns_shell.d_res_low                                     2.02 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             252 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.719 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.85 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Y76 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.99 
_refine.ls_d_res_low                             25.91 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     5284 
_refine.ls_number_reflns_R_free                  303 
_refine.ls_number_reflns_R_work                  4981 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.85 
_refine.ls_percent_reflns_R_free                 5.73 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1719 
_refine.ls_R_factor_R_free                       0.2265 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1688 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.2978 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1211 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.99 
_refine_hist.d_res_low                        25.91 
_refine_hist.number_atoms_solvent             55 
_refine_hist.number_atoms_total               603 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        548 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0087 ? 557 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7796 ? 748 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0542 ? 86  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0040 ? 94  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 2.4385 ? 340 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.99 2.51  . . 142 2481 100.00 . . . . 0.1579 . . . . . . . . . . . 0.2408 
'X-RAY DIFFRACTION' 2.51 25.91 . . 161 2500 99.78  . . . . 0.1730 . . . . . . . . . . . 0.2218 
# 
_struct.entry_id                     8Y76 
_struct.title                        'Crystal structure of the SAM domain of L3MBTL3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Y76 
_struct_keywords.text            'epigenetic, chromatin-binding, polymer, GENE REGULATION' 
_struct_keywords.pdbx_keywords   'GENE REGULATION' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LMBL3_HUMAN 
_struct_ref.pdbx_db_accession          Q96JM7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   VSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAE 
_struct_ref.pdbx_align_begin           705 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Y76 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 70 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q96JM7 
_struct_ref_seq.db_align_beg                  705 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  773 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       459 
_struct_ref_seq.pdbx_auth_seq_align_end       527 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8Y76 
_struct_ref_seq_dif.mon_id                       SER 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      1 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q96JM7 
_struct_ref_seq_dif.db_mon_id                    ? 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          ? 
_struct_ref_seq_dif.details                      'expression tag' 
_struct_ref_seq_dif.pdbx_auth_seq_num            458 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 1  ? TRP A 5  ? SER A 458 TRP A 462 5 ? 5  
HELX_P HELX_P2 AA2 SER A 6  ? SER A 16 ? SER A 463 SER A 473 1 ? 11 
HELX_P HELX_P3 AA3 CYS A 20 ? GLU A 22 ? CYS A 477 GLU A 479 5 ? 3  
HELX_P HELX_P4 AA4 HIS A 23 ? GLU A 30 ? HIS A 480 GLU A 487 1 ? 8  
HELX_P HELX_P5 AA5 ASP A 33 ? LEU A 38 ? ASP A 490 LEU A 495 1 ? 6  
HELX_P HELX_P6 AA6 THR A 41 ? LYS A 47 ? THR A 498 LYS A 504 1 ? 7  
HELX_P HELX_P7 AA7 LYS A 52 ? ALA A 69 ? LYS A 509 ALA A 526 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8Y76 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z         
2 x-y,x,z+5/6   
3 y,-x+y,z+1/6  
4 -y,x-y,z+2/3  
5 -x+y,-x,z+1/3 
6 -x,-y,z+1/2   
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ASN N    N N N 14  
ASN CA   C N S 15  
ASN C    C N N 16  
ASN O    O N N 17  
ASN CB   C N N 18  
ASN CG   C N N 19  
ASN OD1  O N N 20  
ASN ND2  N N N 21  
ASN OXT  O N N 22  
ASN H    H N N 23  
ASN H2   H N N 24  
ASN HA   H N N 25  
ASN HB2  H N N 26  
ASN HB3  H N N 27  
ASN HD21 H N N 28  
ASN HD22 H N N 29  
ASN HXT  H N N 30  
ASP N    N N N 31  
ASP CA   C N S 32  
ASP C    C N N 33  
ASP O    O N N 34  
ASP CB   C N N 35  
ASP CG   C N N 36  
ASP OD1  O N N 37  
ASP OD2  O N N 38  
ASP OXT  O N N 39  
ASP H    H N N 40  
ASP H2   H N N 41  
ASP HA   H N N 42  
ASP HB2  H N N 43  
ASP HB3  H N N 44  
ASP HD2  H N N 45  
ASP HXT  H N N 46  
CYS N    N N N 47  
CYS CA   C N R 48  
CYS C    C N N 49  
CYS O    O N N 50  
CYS CB   C N N 51  
CYS SG   S N N 52  
CYS OXT  O N N 53  
CYS H    H N N 54  
CYS H2   H N N 55  
CYS HA   H N N 56  
CYS HB2  H N N 57  
CYS HB3  H N N 58  
CYS HG   H N N 59  
CYS HXT  H N N 60  
GLN N    N N N 61  
GLN CA   C N S 62  
GLN C    C N N 63  
GLN O    O N N 64  
GLN CB   C N N 65  
GLN CG   C N N 66  
GLN CD   C N N 67  
GLN OE1  O N N 68  
GLN NE2  N N N 69  
GLN OXT  O N N 70  
GLN H    H N N 71  
GLN H2   H N N 72  
GLN HA   H N N 73  
GLN HB2  H N N 74  
GLN HB3  H N N 75  
GLN HG2  H N N 76  
GLN HG3  H N N 77  
GLN HE21 H N N 78  
GLN HE22 H N N 79  
GLN HXT  H N N 80  
GLU N    N N N 81  
GLU CA   C N S 82  
GLU C    C N N 83  
GLU O    O N N 84  
GLU CB   C N N 85  
GLU CG   C N N 86  
GLU CD   C N N 87  
GLU OE1  O N N 88  
GLU OE2  O N N 89  
GLU OXT  O N N 90  
GLU H    H N N 91  
GLU H2   H N N 92  
GLU HA   H N N 93  
GLU HB2  H N N 94  
GLU HB3  H N N 95  
GLU HG2  H N N 96  
GLU HG3  H N N 97  
GLU HE2  H N N 98  
GLU HXT  H N N 99  
GLY N    N N N 100 
GLY CA   C N N 101 
GLY C    C N N 102 
GLY O    O N N 103 
GLY OXT  O N N 104 
GLY H    H N N 105 
GLY H2   H N N 106 
GLY HA2  H N N 107 
GLY HA3  H N N 108 
GLY HXT  H N N 109 
HIS N    N N N 110 
HIS CA   C N S 111 
HIS C    C N N 112 
HIS O    O N N 113 
HIS CB   C N N 114 
HIS CG   C Y N 115 
HIS ND1  N Y N 116 
HIS CD2  C Y N 117 
HIS CE1  C Y N 118 
HIS NE2  N Y N 119 
HIS OXT  O N N 120 
HIS H    H N N 121 
HIS H2   H N N 122 
HIS HA   H N N 123 
HIS HB2  H N N 124 
HIS HB3  H N N 125 
HIS HD1  H N N 126 
HIS HD2  H N N 127 
HIS HE1  H N N 128 
HIS HE2  H N N 129 
HIS HXT  H N N 130 
HOH O    O N N 131 
HOH H1   H N N 132 
HOH H2   H N N 133 
ILE N    N N N 134 
ILE CA   C N S 135 
ILE C    C N N 136 
ILE O    O N N 137 
ILE CB   C N S 138 
ILE CG1  C N N 139 
ILE CG2  C N N 140 
ILE CD1  C N N 141 
ILE OXT  O N N 142 
ILE H    H N N 143 
ILE H2   H N N 144 
ILE HA   H N N 145 
ILE HB   H N N 146 
ILE HG12 H N N 147 
ILE HG13 H N N 148 
ILE HG21 H N N 149 
ILE HG22 H N N 150 
ILE HG23 H N N 151 
ILE HD11 H N N 152 
ILE HD12 H N N 153 
ILE HD13 H N N 154 
ILE HXT  H N N 155 
LEU N    N N N 156 
LEU CA   C N S 157 
LEU C    C N N 158 
LEU O    O N N 159 
LEU CB   C N N 160 
LEU CG   C N N 161 
LEU CD1  C N N 162 
LEU CD2  C N N 163 
LEU OXT  O N N 164 
LEU H    H N N 165 
LEU H2   H N N 166 
LEU HA   H N N 167 
LEU HB2  H N N 168 
LEU HB3  H N N 169 
LEU HG   H N N 170 
LEU HD11 H N N 171 
LEU HD12 H N N 172 
LEU HD13 H N N 173 
LEU HD21 H N N 174 
LEU HD22 H N N 175 
LEU HD23 H N N 176 
LEU HXT  H N N 177 
LYS N    N N N 178 
LYS CA   C N S 179 
LYS C    C N N 180 
LYS O    O N N 181 
LYS CB   C N N 182 
LYS CG   C N N 183 
LYS CD   C N N 184 
LYS CE   C N N 185 
LYS NZ   N N N 186 
LYS OXT  O N N 187 
LYS H    H N N 188 
LYS H2   H N N 189 
LYS HA   H N N 190 
LYS HB2  H N N 191 
LYS HB3  H N N 192 
LYS HG2  H N N 193 
LYS HG3  H N N 194 
LYS HD2  H N N 195 
LYS HD3  H N N 196 
LYS HE2  H N N 197 
LYS HE3  H N N 198 
LYS HZ1  H N N 199 
LYS HZ2  H N N 200 
LYS HZ3  H N N 201 
LYS HXT  H N N 202 
MET N    N N N 203 
MET CA   C N S 204 
MET C    C N N 205 
MET O    O N N 206 
MET CB   C N N 207 
MET CG   C N N 208 
MET SD   S N N 209 
MET CE   C N N 210 
MET OXT  O N N 211 
MET H    H N N 212 
MET H2   H N N 213 
MET HA   H N N 214 
MET HB2  H N N 215 
MET HB3  H N N 216 
MET HG2  H N N 217 
MET HG3  H N N 218 
MET HE1  H N N 219 
MET HE2  H N N 220 
MET HE3  H N N 221 
MET HXT  H N N 222 
PHE N    N N N 223 
PHE CA   C N S 224 
PHE C    C N N 225 
PHE O    O N N 226 
PHE CB   C N N 227 
PHE CG   C Y N 228 
PHE CD1  C Y N 229 
PHE CD2  C Y N 230 
PHE CE1  C Y N 231 
PHE CE2  C Y N 232 
PHE CZ   C Y N 233 
PHE OXT  O N N 234 
PHE H    H N N 235 
PHE H2   H N N 236 
PHE HA   H N N 237 
PHE HB2  H N N 238 
PHE HB3  H N N 239 
PHE HD1  H N N 240 
PHE HD2  H N N 241 
PHE HE1  H N N 242 
PHE HE2  H N N 243 
PHE HZ   H N N 244 
PHE HXT  H N N 245 
PRO N    N N N 246 
PRO CA   C N S 247 
PRO C    C N N 248 
PRO O    O N N 249 
PRO CB   C N N 250 
PRO CG   C N N 251 
PRO CD   C N N 252 
PRO OXT  O N N 253 
PRO H    H N N 254 
PRO HA   H N N 255 
PRO HB2  H N N 256 
PRO HB3  H N N 257 
PRO HG2  H N N 258 
PRO HG3  H N N 259 
PRO HD2  H N N 260 
PRO HD3  H N N 261 
PRO HXT  H N N 262 
SER N    N N N 263 
SER CA   C N S 264 
SER C    C N N 265 
SER O    O N N 266 
SER CB   C N N 267 
SER OG   O N N 268 
SER OXT  O N N 269 
SER H    H N N 270 
SER H2   H N N 271 
SER HA   H N N 272 
SER HB2  H N N 273 
SER HB3  H N N 274 
SER HG   H N N 275 
SER HXT  H N N 276 
THR N    N N N 277 
THR CA   C N S 278 
THR C    C N N 279 
THR O    O N N 280 
THR CB   C N R 281 
THR OG1  O N N 282 
THR CG2  C N N 283 
THR OXT  O N N 284 
THR H    H N N 285 
THR H2   H N N 286 
THR HA   H N N 287 
THR HB   H N N 288 
THR HG1  H N N 289 
THR HG21 H N N 290 
THR HG22 H N N 291 
THR HG23 H N N 292 
THR HXT  H N N 293 
TRP N    N N N 294 
TRP CA   C N S 295 
TRP C    C N N 296 
TRP O    O N N 297 
TRP CB   C N N 298 
TRP CG   C Y N 299 
TRP CD1  C Y N 300 
TRP CD2  C Y N 301 
TRP NE1  N Y N 302 
TRP CE2  C Y N 303 
TRP CE3  C Y N 304 
TRP CZ2  C Y N 305 
TRP CZ3  C Y N 306 
TRP CH2  C Y N 307 
TRP OXT  O N N 308 
TRP H    H N N 309 
TRP H2   H N N 310 
TRP HA   H N N 311 
TRP HB2  H N N 312 
TRP HB3  H N N 313 
TRP HD1  H N N 314 
TRP HE1  H N N 315 
TRP HE3  H N N 316 
TRP HZ2  H N N 317 
TRP HZ3  H N N 318 
TRP HH2  H N N 319 
TRP HXT  H N N 320 
VAL N    N N N 321 
VAL CA   C N S 322 
VAL C    C N N 323 
VAL O    O N N 324 
VAL CB   C N N 325 
VAL CG1  C N N 326 
VAL CG2  C N N 327 
VAL OXT  O N N 328 
VAL H    H N N 329 
VAL H2   H N N 330 
VAL HA   H N N 331 
VAL HB   H N N 332 
VAL HG11 H N N 333 
VAL HG12 H N N 334 
VAL HG13 H N N 335 
VAL HG21 H N N 336 
VAL HG22 H N N 337 
VAL HG23 H N N 338 
VAL HXT  H N N 339 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ASN N   CA   sing N N 13  
ASN N   H    sing N N 14  
ASN N   H2   sing N N 15  
ASN CA  C    sing N N 16  
ASN CA  CB   sing N N 17  
ASN CA  HA   sing N N 18  
ASN C   O    doub N N 19  
ASN C   OXT  sing N N 20  
ASN CB  CG   sing N N 21  
ASN CB  HB2  sing N N 22  
ASN CB  HB3  sing N N 23  
ASN CG  OD1  doub N N 24  
ASN CG  ND2  sing N N 25  
ASN ND2 HD21 sing N N 26  
ASN ND2 HD22 sing N N 27  
ASN OXT HXT  sing N N 28  
ASP N   CA   sing N N 29  
ASP N   H    sing N N 30  
ASP N   H2   sing N N 31  
ASP CA  C    sing N N 32  
ASP CA  CB   sing N N 33  
ASP CA  HA   sing N N 34  
ASP C   O    doub N N 35  
ASP C   OXT  sing N N 36  
ASP CB  CG   sing N N 37  
ASP CB  HB2  sing N N 38  
ASP CB  HB3  sing N N 39  
ASP CG  OD1  doub N N 40  
ASP CG  OD2  sing N N 41  
ASP OD2 HD2  sing N N 42  
ASP OXT HXT  sing N N 43  
CYS N   CA   sing N N 44  
CYS N   H    sing N N 45  
CYS N   H2   sing N N 46  
CYS CA  C    sing N N 47  
CYS CA  CB   sing N N 48  
CYS CA  HA   sing N N 49  
CYS C   O    doub N N 50  
CYS C   OXT  sing N N 51  
CYS CB  SG   sing N N 52  
CYS CB  HB2  sing N N 53  
CYS CB  HB3  sing N N 54  
CYS SG  HG   sing N N 55  
CYS OXT HXT  sing N N 56  
GLN N   CA   sing N N 57  
GLN N   H    sing N N 58  
GLN N   H2   sing N N 59  
GLN CA  C    sing N N 60  
GLN CA  CB   sing N N 61  
GLN CA  HA   sing N N 62  
GLN C   O    doub N N 63  
GLN C   OXT  sing N N 64  
GLN CB  CG   sing N N 65  
GLN CB  HB2  sing N N 66  
GLN CB  HB3  sing N N 67  
GLN CG  CD   sing N N 68  
GLN CG  HG2  sing N N 69  
GLN CG  HG3  sing N N 70  
GLN CD  OE1  doub N N 71  
GLN CD  NE2  sing N N 72  
GLN NE2 HE21 sing N N 73  
GLN NE2 HE22 sing N N 74  
GLN OXT HXT  sing N N 75  
GLU N   CA   sing N N 76  
GLU N   H    sing N N 77  
GLU N   H2   sing N N 78  
GLU CA  C    sing N N 79  
GLU CA  CB   sing N N 80  
GLU CA  HA   sing N N 81  
GLU C   O    doub N N 82  
GLU C   OXT  sing N N 83  
GLU CB  CG   sing N N 84  
GLU CB  HB2  sing N N 85  
GLU CB  HB3  sing N N 86  
GLU CG  CD   sing N N 87  
GLU CG  HG2  sing N N 88  
GLU CG  HG3  sing N N 89  
GLU CD  OE1  doub N N 90  
GLU CD  OE2  sing N N 91  
GLU OE2 HE2  sing N N 92  
GLU OXT HXT  sing N N 93  
GLY N   CA   sing N N 94  
GLY N   H    sing N N 95  
GLY N   H2   sing N N 96  
GLY CA  C    sing N N 97  
GLY CA  HA2  sing N N 98  
GLY CA  HA3  sing N N 99  
GLY C   O    doub N N 100 
GLY C   OXT  sing N N 101 
GLY OXT HXT  sing N N 102 
HIS N   CA   sing N N 103 
HIS N   H    sing N N 104 
HIS N   H2   sing N N 105 
HIS CA  C    sing N N 106 
HIS CA  CB   sing N N 107 
HIS CA  HA   sing N N 108 
HIS C   O    doub N N 109 
HIS C   OXT  sing N N 110 
HIS CB  CG   sing N N 111 
HIS CB  HB2  sing N N 112 
HIS CB  HB3  sing N N 113 
HIS CG  ND1  sing Y N 114 
HIS CG  CD2  doub Y N 115 
HIS ND1 CE1  doub Y N 116 
HIS ND1 HD1  sing N N 117 
HIS CD2 NE2  sing Y N 118 
HIS CD2 HD2  sing N N 119 
HIS CE1 NE2  sing Y N 120 
HIS CE1 HE1  sing N N 121 
HIS NE2 HE2  sing N N 122 
HIS OXT HXT  sing N N 123 
HOH O   H1   sing N N 124 
HOH O   H2   sing N N 125 
ILE N   CA   sing N N 126 
ILE N   H    sing N N 127 
ILE N   H2   sing N N 128 
ILE CA  C    sing N N 129 
ILE CA  CB   sing N N 130 
ILE CA  HA   sing N N 131 
ILE C   O    doub N N 132 
ILE C   OXT  sing N N 133 
ILE CB  CG1  sing N N 134 
ILE CB  CG2  sing N N 135 
ILE CB  HB   sing N N 136 
ILE CG1 CD1  sing N N 137 
ILE CG1 HG12 sing N N 138 
ILE CG1 HG13 sing N N 139 
ILE CG2 HG21 sing N N 140 
ILE CG2 HG22 sing N N 141 
ILE CG2 HG23 sing N N 142 
ILE CD1 HD11 sing N N 143 
ILE CD1 HD12 sing N N 144 
ILE CD1 HD13 sing N N 145 
ILE OXT HXT  sing N N 146 
LEU N   CA   sing N N 147 
LEU N   H    sing N N 148 
LEU N   H2   sing N N 149 
LEU CA  C    sing N N 150 
LEU CA  CB   sing N N 151 
LEU CA  HA   sing N N 152 
LEU C   O    doub N N 153 
LEU C   OXT  sing N N 154 
LEU CB  CG   sing N N 155 
LEU CB  HB2  sing N N 156 
LEU CB  HB3  sing N N 157 
LEU CG  CD1  sing N N 158 
LEU CG  CD2  sing N N 159 
LEU CG  HG   sing N N 160 
LEU CD1 HD11 sing N N 161 
LEU CD1 HD12 sing N N 162 
LEU CD1 HD13 sing N N 163 
LEU CD2 HD21 sing N N 164 
LEU CD2 HD22 sing N N 165 
LEU CD2 HD23 sing N N 166 
LEU OXT HXT  sing N N 167 
LYS N   CA   sing N N 168 
LYS N   H    sing N N 169 
LYS N   H2   sing N N 170 
LYS CA  C    sing N N 171 
LYS CA  CB   sing N N 172 
LYS CA  HA   sing N N 173 
LYS C   O    doub N N 174 
LYS C   OXT  sing N N 175 
LYS CB  CG   sing N N 176 
LYS CB  HB2  sing N N 177 
LYS CB  HB3  sing N N 178 
LYS CG  CD   sing N N 179 
LYS CG  HG2  sing N N 180 
LYS CG  HG3  sing N N 181 
LYS CD  CE   sing N N 182 
LYS CD  HD2  sing N N 183 
LYS CD  HD3  sing N N 184 
LYS CE  NZ   sing N N 185 
LYS CE  HE2  sing N N 186 
LYS CE  HE3  sing N N 187 
LYS NZ  HZ1  sing N N 188 
LYS NZ  HZ2  sing N N 189 
LYS NZ  HZ3  sing N N 190 
LYS OXT HXT  sing N N 191 
MET N   CA   sing N N 192 
MET N   H    sing N N 193 
MET N   H2   sing N N 194 
MET CA  C    sing N N 195 
MET CA  CB   sing N N 196 
MET CA  HA   sing N N 197 
MET C   O    doub N N 198 
MET C   OXT  sing N N 199 
MET CB  CG   sing N N 200 
MET CB  HB2  sing N N 201 
MET CB  HB3  sing N N 202 
MET CG  SD   sing N N 203 
MET CG  HG2  sing N N 204 
MET CG  HG3  sing N N 205 
MET SD  CE   sing N N 206 
MET CE  HE1  sing N N 207 
MET CE  HE2  sing N N 208 
MET CE  HE3  sing N N 209 
MET OXT HXT  sing N N 210 
PHE N   CA   sing N N 211 
PHE N   H    sing N N 212 
PHE N   H2   sing N N 213 
PHE CA  C    sing N N 214 
PHE CA  CB   sing N N 215 
PHE CA  HA   sing N N 216 
PHE C   O    doub N N 217 
PHE C   OXT  sing N N 218 
PHE CB  CG   sing N N 219 
PHE CB  HB2  sing N N 220 
PHE CB  HB3  sing N N 221 
PHE CG  CD1  doub Y N 222 
PHE CG  CD2  sing Y N 223 
PHE CD1 CE1  sing Y N 224 
PHE CD1 HD1  sing N N 225 
PHE CD2 CE2  doub Y N 226 
PHE CD2 HD2  sing N N 227 
PHE CE1 CZ   doub Y N 228 
PHE CE1 HE1  sing N N 229 
PHE CE2 CZ   sing Y N 230 
PHE CE2 HE2  sing N N 231 
PHE CZ  HZ   sing N N 232 
PHE OXT HXT  sing N N 233 
PRO N   CA   sing N N 234 
PRO N   CD   sing N N 235 
PRO N   H    sing N N 236 
PRO CA  C    sing N N 237 
PRO CA  CB   sing N N 238 
PRO CA  HA   sing N N 239 
PRO C   O    doub N N 240 
PRO C   OXT  sing N N 241 
PRO CB  CG   sing N N 242 
PRO CB  HB2  sing N N 243 
PRO CB  HB3  sing N N 244 
PRO CG  CD   sing N N 245 
PRO CG  HG2  sing N N 246 
PRO CG  HG3  sing N N 247 
PRO CD  HD2  sing N N 248 
PRO CD  HD3  sing N N 249 
PRO OXT HXT  sing N N 250 
SER N   CA   sing N N 251 
SER N   H    sing N N 252 
SER N   H2   sing N N 253 
SER CA  C    sing N N 254 
SER CA  CB   sing N N 255 
SER CA  HA   sing N N 256 
SER C   O    doub N N 257 
SER C   OXT  sing N N 258 
SER CB  OG   sing N N 259 
SER CB  HB2  sing N N 260 
SER CB  HB3  sing N N 261 
SER OG  HG   sing N N 262 
SER OXT HXT  sing N N 263 
THR N   CA   sing N N 264 
THR N   H    sing N N 265 
THR N   H2   sing N N 266 
THR CA  C    sing N N 267 
THR CA  CB   sing N N 268 
THR CA  HA   sing N N 269 
THR C   O    doub N N 270 
THR C   OXT  sing N N 271 
THR CB  OG1  sing N N 272 
THR CB  CG2  sing N N 273 
THR CB  HB   sing N N 274 
THR OG1 HG1  sing N N 275 
THR CG2 HG21 sing N N 276 
THR CG2 HG22 sing N N 277 
THR CG2 HG23 sing N N 278 
THR OXT HXT  sing N N 279 
TRP N   CA   sing N N 280 
TRP N   H    sing N N 281 
TRP N   H2   sing N N 282 
TRP CA  C    sing N N 283 
TRP CA  CB   sing N N 284 
TRP CA  HA   sing N N 285 
TRP C   O    doub N N 286 
TRP C   OXT  sing N N 287 
TRP CB  CG   sing N N 288 
TRP CB  HB2  sing N N 289 
TRP CB  HB3  sing N N 290 
TRP CG  CD1  doub Y N 291 
TRP CG  CD2  sing Y N 292 
TRP CD1 NE1  sing Y N 293 
TRP CD1 HD1  sing N N 294 
TRP CD2 CE2  doub Y N 295 
TRP CD2 CE3  sing Y N 296 
TRP NE1 CE2  sing Y N 297 
TRP NE1 HE1  sing N N 298 
TRP CE2 CZ2  sing Y N 299 
TRP CE3 CZ3  doub Y N 300 
TRP CE3 HE3  sing N N 301 
TRP CZ2 CH2  doub Y N 302 
TRP CZ2 HZ2  sing N N 303 
TRP CZ3 CH2  sing Y N 304 
TRP CZ3 HZ3  sing N N 305 
TRP CH2 HH2  sing N N 306 
TRP OXT HXT  sing N N 307 
VAL N   CA   sing N N 308 
VAL N   H    sing N N 309 
VAL N   H2   sing N N 310 
VAL CA  C    sing N N 311 
VAL CA  CB   sing N N 312 
VAL CA  HA   sing N N 313 
VAL C   O    doub N N 314 
VAL C   OXT  sing N N 315 
VAL CB  CG1  sing N N 316 
VAL CB  CG2  sing N N 317 
VAL CB  HB   sing N N 318 
VAL CG1 HG11 sing N N 319 
VAL CG1 HG12 sing N N 320 
VAL CG1 HG13 sing N N 321 
VAL CG2 HG21 sing N N 322 
VAL CG2 HG22 sing N N 323 
VAL CG2 HG23 sing N N 324 
VAL OXT HXT  sing N N 325 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Natural Science Foundation of China (NSFC)' China 32071204 1 
'National Natural Science Foundation of China (NSFC)' China 32125008 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6LUJ 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 65' 
_space_group.name_Hall        'P 65' 
_space_group.IT_number        170 
_space_group.crystal_system   hexagonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8Y76 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019298 
_atom_sites.fract_transf_matrix[1][2]   0.011141 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.022283 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.020067 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1   N N   . SER A 1 1  ? -31.18710 0.95628  11.47142  1.000 22.66320 ? 458 SER A N   1 
ATOM   2   C CA  . SER A 1 1  ? -29.92597 1.64095  11.73071  1.000 25.28795 ? 458 SER A CA  1 
ATOM   3   C C   . SER A 1 1  ? -29.11395 1.76902  10.45234  1.000 24.79772 ? 458 SER A C   1 
ATOM   4   O O   . SER A 1 1  ? -29.57032 1.37100  9.38724   1.000 24.91323 ? 458 SER A O   1 
ATOM   5   C CB  . SER A 1 1  ? -29.10726 0.89805  12.78325  1.000 23.78864 ? 458 SER A CB  1 
ATOM   6   O OG  . SER A 1 1  ? -28.93867 -0.46128 12.41860  1.000 26.08109 ? 458 SER A OG  1 
ATOM   7   N N   . VAL A 1 2  ? -27.89415 2.29757  10.57574  1.000 21.52871 ? 459 VAL A N   1 
ATOM   8   C CA  . VAL A 1 2  ? -27.06985 2.57359  9.40260   1.000 22.87643 ? 459 VAL A CA  1 
ATOM   9   C C   . VAL A 1 2  ? -26.98173 1.35280  8.50182   1.000 23.46717 ? 459 VAL A C   1 
ATOM   10  O O   . VAL A 1 2  ? -27.04383 1.46724  7.27479   1.000 22.55761 ? 459 VAL A O   1 
ATOM   11  C CB  . VAL A 1 2  ? -25.67522 3.05495  9.83470   1.000 22.63542 ? 459 VAL A CB  1 
ATOM   12  C CG1 . VAL A 1 2  ? -24.78290 3.21761  8.62512   1.000 22.65752 ? 459 VAL A CG1 1 
ATOM   13  C CG2 . VAL A 1 2  ? -25.78569 4.35845  10.60296  1.000 22.84868 ? 459 VAL A CG2 1 
ATOM   14  N N   . SER A 1 3  ? -26.89817 0.16059  9.09921   1.000 23.34767 ? 460 SER A N   1 
ATOM   15  C CA  . SER A 1 3  ? -26.70036 -1.06149 8.32822   1.000 23.65116 ? 460 SER A CA  1 
ATOM   16  C C   . SER A 1 3  ? -27.81094 -1.32102 7.31264   1.000 24.92461 ? 460 SER A C   1 
ATOM   17  O O   . SER A 1 3  ? -27.55973 -2.00360 6.31676   1.000 24.26767 ? 460 SER A O   1 
ATOM   18  C CB  . SER A 1 3  ? -26.57657 -2.25422 9.27611   1.000 24.99401 ? 460 SER A CB  1 
ATOM   19  O OG  . SER A 1 3  ? -27.69931 -2.31429 10.13464  1.000 28.52881 ? 460 SER A OG  1 
ATOM   20  N N   . LYS A 1 4  ? -29.02177 -0.80343 7.52612   1.000 24.96051 ? 461 LYS A N   1 
ATOM   21  C CA  . LYS A 1 4  ? -30.11370 -0.94640 6.56530   1.000 23.21083 ? 461 LYS A CA  1 
ATOM   22  C C   . LYS A 1 4  ? -30.29622 0.28332  5.67929   1.000 25.99270 ? 461 LYS A C   1 
ATOM   23  O O   . LYS A 1 4  ? -31.24103 0.32347  4.88622   1.000 25.60097 ? 461 LYS A O   1 
ATOM   24  C CB  . LYS A 1 4  ? -31.44732 -1.25994 7.27674   1.000 27.84659 ? 461 LYS A CB  1 
ATOM   25  C CG  . LYS A 1 4  ? -31.89612 -0.27634 8.39260   1.000 34.74336 ? 461 LYS A CG  1 
ATOM   26  C CD  . LYS A 1 4  ? -32.47447 1.10253  7.92347   1.000 35.29212 ? 461 LYS A CD  1 
ATOM   27  C CE  . LYS A 1 4  ? -32.90795 1.98122  9.14286   1.000 27.49938 ? 461 LYS A CE  1 
ATOM   28  N NZ  . LYS A 1 4  ? -33.65526 3.24085  8.85623   1.000 29.55544 ? 461 LYS A NZ  1 
ATOM   29  N N   . TRP A 1 5  ? -29.43969 1.29443  5.80085   1.000 23.35041 ? 462 TRP A N   1 
ATOM   30  C CA  . TRP A 1 5  ? -29.62668 2.49550  4.99849   1.000 22.60890 ? 462 TRP A CA  1 
ATOM   31  C C   . TRP A 1 5  ? -29.49021 2.16792  3.52230   1.000 23.85402 ? 462 TRP A C   1 
ATOM   32  O O   . TRP A 1 5  ? -28.63570 1.37238  3.12119   1.000 24.08261 ? 462 TRP A O   1 
ATOM   33  C CB  . TRP A 1 5  ? -28.61063 3.56835  5.36319   1.000 23.62216 ? 462 TRP A CB  1 
ATOM   34  C CG  . TRP A 1 5  ? -28.89463 4.27842  6.63405   1.000 21.69172 ? 462 TRP A CG  1 
ATOM   35  C CD1 . TRP A 1 5  ? -29.88559 3.99694  7.54166   1.000 23.92308 ? 462 TRP A CD1 1 
ATOM   36  C CD2 . TRP A 1 5  ? -28.17867 5.39774  7.15141   1.000 23.39315 ? 462 TRP A CD2 1 
ATOM   37  N NE1 . TRP A 1 5  ? -29.82709 4.88521  8.59150   1.000 21.60340 ? 462 TRP A NE1 1 
ATOM   38  C CE2 . TRP A 1 5  ? -28.78723 5.75304  8.37592   1.000 20.55677 ? 462 TRP A CE2 1 
ATOM   39  C CE3 . TRP A 1 5  ? -27.08070 6.14423  6.69542   1.000 21.78931 ? 462 TRP A CE3 1 
ATOM   40  C CZ2 . TRP A 1 5  ? -28.33071 6.81000  9.14801   1.000 22.60127 ? 462 TRP A CZ2 1 
ATOM   41  C CZ3 . TRP A 1 5  ? -26.63063 7.19208  7.46609   1.000 21.49823 ? 462 TRP A CZ3 1 
ATOM   42  C CH2 . TRP A 1 5  ? -27.25057 7.51479  8.67896   1.000 23.93652 ? 462 TRP A CH2 1 
ATOM   43  N N   . SER A 1 6  ? -30.34654 2.78067  2.71705   1.000 21.07346 ? 463 SER A N   1 
ATOM   44  C CA  . SER A 1 6  ? -30.23104 2.62645  1.28321   1.000 23.22738 ? 463 SER A CA  1 
ATOM   45  C C   . SER A 1 6  ? -29.08703 3.47737  0.75825   1.000 24.26086 ? 463 SER A C   1 
ATOM   46  O O   . SER A 1 6  ? -28.47152 4.27461  1.46897   1.000 22.39954 ? 463 SER A O   1 
ATOM   47  C CB  . SER A 1 6  ? -31.53071 3.01525  0.57601   1.000 20.58919 ? 463 SER A CB  1 
ATOM   48  O OG  . SER A 1 6  ? -31.66831 4.42697  0.54408   1.000 22.11668 ? 463 SER A OG  1 
ATOM   49  N N   . THR A 1 7  ? -28.80566 3.26736  -0.51873  1.000 22.34155 ? 464 THR A N   1 
ATOM   50  C CA  . THR A 1 7  ? -27.79360 4.03092  -1.22194  1.000 21.98973 ? 464 THR A CA  1 
ATOM   51  C C   . THR A 1 7  ? -28.14595 5.52326  -1.24727  1.000 24.65923 ? 464 THR A C   1 
ATOM   52  O O   . THR A 1 7  ? -27.27067 6.38296  -1.06553  1.000 22.53782 ? 464 THR A O   1 
ATOM   53  C CB  . THR A 1 7  ? -27.67115 3.39872  -2.61275  1.000 26.79068 ? 464 THR A CB  1 
ATOM   54  O OG1 . THR A 1 7  ? -26.31212 3.04297  -2.90995  1.000 30.09308 ? 464 THR A OG1 1 
ATOM   55  C CG2 . THR A 1 7  ? -28.25549 4.24006  -3.63564  1.000 24.96034 ? 464 THR A CG2 1 
ATOM   56  N N   . ASP A 1 8  ? -29.43167 5.85329  -1.40914  1.000 21.72386 ? 465 ASP A N   1 
ATOM   57  C CA  . ASP A 1 8  ? -29.83997 7.25220  -1.33945  1.000 23.63875 ? 465 ASP A CA  1 
ATOM   58  C C   . ASP A 1 8  ? -29.66595 7.79896  0.06995   1.000 22.89015 ? 465 ASP A C   1 
ATOM   59  O O   . ASP A 1 8  ? -29.28080 8.95920  0.25165   1.000 19.62506 ? 465 ASP A O   1 
ATOM   60  C CB  . ASP A 1 8  ? -31.29246 7.40549  -1.78718  1.000 24.82433 ? 465 ASP A CB  1 
ATOM   61  C CG  . ASP A 1 8  ? -31.46347 7.26117  -3.29330  1.000 28.19773 ? 465 ASP A CG  1 
ATOM   62  O OD1 . ASP A 1 8  ? -32.60487 7.02690  -3.74052  1.000 32.20178 ? 465 ASP A OD1 1 
ATOM   63  O OD2 . ASP A 1 8  ? -30.46457 7.37525  -4.02681  1.000 28.15900 ? 465 ASP A OD2 1 
ATOM   64  N N   . GLU A 1 9  ? -29.92639 6.96952  1.08059   1.000 22.64726 ? 466 GLU A N   1 
ATOM   65  C CA  . GLU A 1 9  ? -29.83893 7.43584  2.45881   1.000 21.60219 ? 466 GLU A CA  1 
ATOM   66  C C   . GLU A 1 9  ? -28.39883 7.71185  2.87564   1.000 23.08284 ? 466 GLU A C   1 
ATOM   67  O O   . GLU A 1 9  ? -28.14841 8.62702  3.66764   1.000 22.67399 ? 466 GLU A O   1 
ATOM   68  C CB  . GLU A 1 9  ? -30.49779 6.41561  3.38131   1.000 21.61544 ? 466 GLU A CB  1 
ATOM   69  C CG  . GLU A 1 9  ? -32.02029 6.52354  3.32943   1.000 24.21272 ? 466 GLU A CG  1 
ATOM   70  C CD  . GLU A 1 9  ? -32.72660 5.39380  4.03199   1.000 25.48874 ? 466 GLU A CD  1 
ATOM   71  O OE1 . GLU A 1 9  ? -32.16715 4.27157  4.08784   1.000 27.24923 ? 466 GLU A OE1 1 
ATOM   72  O OE2 . GLU A 1 9  ? -33.85674 5.62738  4.50352   1.000 27.73200 ? 466 GLU A OE2 1 
ATOM   73  N N   . VAL A 1 10 ? -27.43821 6.95745  2.34740   1.000 20.41702 ? 467 VAL A N   1 
ATOM   74  C CA  . VAL A 1 10 ? -26.04204 7.24419  2.66275   1.000 21.42472 ? 467 VAL A CA  1 
ATOM   75  C C   . VAL A 1 10 ? -25.60974 8.53368  1.98569   1.000 21.29246 ? 467 VAL A C   1 
ATOM   76  O O   . VAL A 1 10 ? -24.99321 9.40593  2.61183   1.000 20.71697 ? 467 VAL A O   1 
ATOM   77  C CB  . VAL A 1 10 ? -25.14614 6.05898  2.26507   1.000 21.28317 ? 467 VAL A CB  1 
ATOM   78  C CG1 . VAL A 1 10 ? -23.68024 6.43943  2.30299   1.000 22.91731 ? 467 VAL A CG1 1 
ATOM   79  C CG2 . VAL A 1 10 ? -25.40300 4.89576  3.19480   1.000 21.81318 ? 467 VAL A CG2 1 
ATOM   80  N N   . SER A 1 11 ? -25.94992 8.68445  0.70140   1.000 18.98010 ? 468 SER A N   1 
ATOM   81  C CA  . SER A 1 11 ? -25.55024 9.87514  -0.03678  1.000 22.11791 ? 468 SER A CA  1 
ATOM   82  C C   . SER A 1 11 ? -26.14548 11.13597 0.57926   1.000 21.81666 ? 468 SER A C   1 
ATOM   83  O O   . SER A 1 11 ? -25.46338 12.16071 0.69823   1.000 23.35573 ? 468 SER A O   1 
ATOM   84  C CB  . SER A 1 11 ? -25.97215 9.74635  -1.49603  1.000 23.64704 ? 468 SER A CB  1 
ATOM   85  O OG  . SER A 1 11 ? -25.86138 10.99169 -2.13999  1.000 20.80199 ? 468 SER A OG  1 
ATOM   86  N N   . GLU A 1 12 ? -27.41704 11.07597 0.97870   1.000 23.43900 ? 469 GLU A N   1 
ATOM   87  C CA  . GLU A 1 12 ? -28.02995 12.18298 1.70697   1.000 23.86621 ? 469 GLU A CA  1 
ATOM   88  C C   . GLU A 1 12 ? -27.29125 12.46129 3.00766   1.000 23.40508 ? 469 GLU A C   1 
ATOM   89  O O   . GLU A 1 12 ? -27.06737 13.62251 3.36940   1.000 22.95026 ? 469 GLU A O   1 
ATOM   90  C CB  . GLU A 1 12 ? -29.49172 11.86919 2.00959   1.000 24.95124 ? 469 GLU A CB  1 
ATOM   91  C CG  . GLU A 1 12 ? -30.45644 12.21204 0.92020   1.000 31.62746 ? 469 GLU A CG  1 
ATOM   92  C CD  . GLU A 1 12 ? -31.57234 11.20004 0.84007   1.000 36.87046 ? 469 GLU A CD  1 
ATOM   93  O OE1 . GLU A 1 12 ? -31.90632 10.61194 1.89676   1.000 39.34084 ? 469 GLU A OE1 1 
ATOM   94  O OE2 . GLU A 1 12 ? -32.12490 11.01195 -0.26572  1.000 42.36913 ? 469 GLU A OE2 1 
ATOM   95  N N   . PHE A 1 13 ? -26.93570 11.40912 3.75301   1.000 22.07070 ? 470 PHE A N   1 
ATOM   96  C CA  . PHE A 1 13 ? -26.24670 11.65314 5.01923   1.000 22.41036 ? 470 PHE A CA  1 
ATOM   97  C C   . PHE A 1 13 ? -24.90379 12.33173 4.78675   1.000 22.37390 ? 470 PHE A C   1 
ATOM   98  O O   . PHE A 1 13 ? -24.53589 13.27326 5.50416   1.000 22.66608 ? 470 PHE A O   1 
ATOM   99  C CB  . PHE A 1 13 ? -26.03074 10.36109 5.80957   1.000 23.23520 ? 470 PHE A CB  1 
ATOM   100 C CG  . PHE A 1 13 ? -25.01531 10.52092 6.91421   1.000 25.17369 ? 470 PHE A CG  1 
ATOM   101 C CD1 . PHE A 1 13 ? -25.37162 11.12722 8.10826   1.000 23.69348 ? 470 PHE A CD1 1 
ATOM   102 C CD2 . PHE A 1 13 ? -23.69244 10.12969 6.73455   1.000 24.34729 ? 470 PHE A CD2 1 
ATOM   103 C CE1 . PHE A 1 13 ? -24.44131 11.31455 9.10898   1.000 26.21162 ? 470 PHE A CE1 1 
ATOM   104 C CE2 . PHE A 1 13 ? -22.75916 10.31236 7.73311   1.000 21.72884 ? 470 PHE A CE2 1 
ATOM   105 C CZ  . PHE A 1 13 ? -23.12870 10.90601 8.91984   1.000 26.18790 ? 470 PHE A CZ  1 
ATOM   106 N N   . ILE A 1 14 ? -24.14499 11.84779 3.80374   1.000 21.51360 ? 471 ILE A N   1 
ATOM   107 C CA  . ILE A 1 14 ? -22.83432 12.42738 3.53129   1.000 21.11325 ? 471 ILE A CA  1 
ATOM   108 C C   . ILE A 1 14 ? -22.96286 13.89996 3.16610   1.000 21.65580 ? 471 ILE A C   1 
ATOM   109 O O   . ILE A 1 14 ? -22.15676 14.72984 3.60052   1.000 21.05108 ? 471 ILE A O   1 
ATOM   110 C CB  . ILE A 1 14 ? -22.11898 11.59929 2.45293   1.000 23.09306 ? 471 ILE A CB  1 
ATOM   111 C CG1 . ILE A 1 14 ? -21.46653 10.41482 3.16123   1.000 26.04639 ? 471 ILE A CG1 1 
ATOM   112 C CG2 . ILE A 1 14 ? -21.06766 12.42556 1.71752   1.000 20.57121 ? 471 ILE A CG2 1 
ATOM   113 C CD1 . ILE A 1 14 ? -21.22084 9.31492  2.30560   1.000 30.37989 ? 471 ILE A CD1 1 
ATOM   114 N N   . GLN A 1 15 ? -23.99745 14.25966 2.39879   1.000 24.09399 ? 472 GLN A N   1 
ATOM   115 C CA  . GLN A 1 15 ? -24.19545 15.66831 2.06423   1.000 22.31372 ? 472 GLN A CA  1 
ATOM   116 C C   . GLN A 1 15 ? -24.53582 16.49740 3.28667   1.000 23.47795 ? 472 GLN A C   1 
ATOM   117 O O   . GLN A 1 15 ? -24.29592 17.70967 3.28504   1.000 26.35044 ? 472 GLN A O   1 
ATOM   118 C CB  . GLN A 1 15 ? -25.29839 15.82461 1.02202   1.000 23.97339 ? 472 GLN A CB  1 
ATOM   119 C CG  . GLN A 1 15 ? -25.02352 15.05776 -0.24585  1.000 24.81450 ? 472 GLN A CG  1 
ATOM   120 C CD  . GLN A 1 15 ? -26.17068 15.13947 -1.21253  1.000 27.51893 ? 472 GLN A CD  1 
ATOM   121 O OE1 . GLN A 1 15 ? -26.66428 16.22576 -1.51420  1.000 30.98785 ? 472 GLN A OE1 1 
ATOM   122 N NE2 . GLN A 1 15 ? -26.60589 13.99049 -1.71301  1.000 31.54715 ? 472 GLN A NE2 1 
ATOM   123 N N   . SER A 1 16 ? -25.07830 15.86649 4.32360   1.000 21.60788 ? 473 SER A N   1 
ATOM   124 C CA  . SER A 1 16 ? -25.43227 16.55043 5.55782   1.000 26.65006 ? 473 SER A CA  1 
ATOM   125 C C   . SER A 1 16 ? -24.23095 16.84758 6.44083   1.000 26.37870 ? 473 SER A C   1 
ATOM   126 O O   . SER A 1 16 ? -24.37781 17.58343 7.42450   1.000 26.82284 ? 473 SER A O   1 
ATOM   127 C CB  . SER A 1 16 ? -26.43800 15.71248 6.34585   1.000 24.67968 ? 473 SER A CB  1 
ATOM   128 O OG  . SER A 1 16 ? -25.75207 14.74588 7.12222   1.000 24.04033 ? 473 SER A OG  1 
ATOM   129 N N   . LEU A 1 17 ? -23.06029 16.28531 6.13276   1.000 22.84426 ? 474 LEU A N   1 
ATOM   130 C CA  . LEU A 1 17 ? -21.89483 16.58958 6.94872   1.000 25.45060 ? 474 LEU A CA  1 
ATOM   131 C C   . LEU A 1 17 ? -21.27265 17.90738 6.48758   1.000 24.70068 ? 474 LEU A C   1 
ATOM   132 O O   . LEU A 1 17 ? -21.27269 18.20708 5.29247   1.000 23.69221 ? 474 LEU A O   1 
ATOM   133 C CB  . LEU A 1 17 ? -20.85875 15.46263 6.86858   1.000 22.99872 ? 474 LEU A CB  1 
ATOM   134 C CG  . LEU A 1 17 ? -21.28235 14.09051 7.40157   1.000 23.89956 ? 474 LEU A CG  1 
ATOM   135 C CD1 . LEU A 1 17 ? -20.30795 13.01314 6.94019   1.000 25.42374 ? 474 LEU A CD1 1 
ATOM   136 C CD2 . LEU A 1 17 ? -21.37388 14.11743 8.90982   1.000 27.20631 ? 474 LEU A CD2 1 
ATOM   137 N N   . PRO A 1 18 ? -20.76049 18.71790 7.41284   1.000 23.82142 ? 475 PRO A N   1 
ATOM   138 C CA  . PRO A 1 18 ? -20.20843 20.02570 7.02548   1.000 26.82593 ? 475 PRO A CA  1 
ATOM   139 C C   . PRO A 1 18 ? -19.07210 19.89224 6.01721   1.000 24.92931 ? 475 PRO A C   1 
ATOM   140 O O   . PRO A 1 18 ? -18.13637 19.10756 6.20068   1.000 24.06196 ? 475 PRO A O   1 
ATOM   141 C CB  . PRO A 1 18 ? -19.72102 20.61408 8.35725   1.000 26.90389 ? 475 PRO A CB  1 
ATOM   142 C CG  . PRO A 1 18 ? -19.62160 19.43547 9.29533   1.000 29.44501 ? 475 PRO A CG  1 
ATOM   143 C CD  . PRO A 1 18 ? -20.69813 18.49198 8.86575   1.000 26.71098 ? 475 PRO A CD  1 
ATOM   144 N N   . GLY A 1 19 ? -19.16797 20.66438 4.93713   1.000 21.98039 ? 476 GLY A N   1 
ATOM   145 C CA  . GLY A 1 19 ? -18.13938 20.65145 3.91803   1.000 23.24248 ? 476 GLY A CA  1 
ATOM   146 C C   . GLY A 1 19 ? -18.13989 19.44025 3.01508   1.000 23.79458 ? 476 GLY A C   1 
ATOM   147 O O   . GLY A 1 19 ? -17.21921 19.29109 2.20985   1.000 23.13831 ? 476 GLY A O   1 
ATOM   148 N N   . CYS A 1 20 ? -19.14917 18.57591 3.10001   1.000 23.78749 ? 477 CYS A N   1 
ATOM   149 C CA  . CYS A 1 20 ? -19.14139 17.32044 2.35818   1.000 22.32353 ? 477 CYS A CA  1 
ATOM   150 C C   . CYS A 1 20 ? -20.22473 17.23984 1.29383   1.000 22.03110 ? 477 CYS A C   1 
ATOM   151 O O   . CYS A 1 20 ? -20.43719 16.16481 0.72759   1.000 23.12120 ? 477 CYS A O   1 
ATOM   152 C CB  . CYS A 1 20 ? -19.27522 16.15101 3.32947   1.000 23.54779 ? 477 CYS A CB  1 
ATOM   153 S SG  . CYS A 1 20 ? -17.84564 15.97141 4.38993   1.000 23.55595 ? 477 CYS A SG  1 
ATOM   154 N N   . GLU A 1 21 ? -20.89571 18.35280 0.99213   1.000 24.15655 ? 478 GLU A N   1 
ATOM   155 C CA  . GLU A 1 21 ? -22.02128 18.33310 0.05601   1.000 24.57732 ? 478 GLU A CA  1 
ATOM   156 C C   . GLU A 1 21 ? -21.63656 17.76272 -1.31670  1.000 24.85816 ? 478 GLU A C   1 
ATOM   157 O O   . GLU A 1 21 ? -22.43766 17.05865 -1.94706  1.000 23.35273 ? 478 GLU A O   1 
ATOM   158 C CB  . GLU A 1 21 ? -22.58530 19.74570 -0.08152  1.000 27.13597 ? 478 GLU A CB  1 
ATOM   159 C CG  . GLU A 1 21 ? -23.21144 20.28496 1.20589   1.000 24.87802 ? 478 GLU A CG  1 
ATOM   160 C CD  . GLU A 1 21 ? -22.22769 21.03693 2.08192   1.000 29.99006 ? 478 GLU A CD  1 
ATOM   161 O OE1 . GLU A 1 21 ? -20.99403 20.89601 1.89099   1.000 26.44230 ? 478 GLU A OE1 1 
ATOM   162 O OE2 . GLU A 1 21 ? -22.69392 21.78501 2.97161   1.000 34.65476 ? 478 GLU A OE2 1 
ATOM   163 N N   . GLU A 1 22 ? -20.41206 18.02858 -1.78882  1.000 20.30221 ? 479 GLU A N   1 
ATOM   164 C CA  . GLU A 1 22 ? -20.02538 17.59146 -3.13196  1.000 22.10038 ? 479 GLU A CA  1 
ATOM   165 C C   . GLU A 1 22 ? -19.89105 16.08107 -3.25581  1.000 23.48083 ? 479 GLU A C   1 
ATOM   166 O O   . GLU A 1 22 ? -19.84045 15.57035 -4.37848  1.000 21.42563 ? 479 GLU A O   1 
ATOM   167 C CB  . GLU A 1 22 ? -18.70069 18.22974 -3.54906  1.000 20.55571 ? 479 GLU A CB  1 
ATOM   168 C CG  . GLU A 1 22 ? -17.48323 17.59054 -2.89129  1.000 23.77249 ? 479 GLU A CG  1 
ATOM   169 C CD  . GLU A 1 22 ? -16.20740 18.39496 -3.09433  1.000 23.95609 ? 479 GLU A CD  1 
ATOM   170 O OE1 . GLU A 1 22 ? -15.42131 18.06244 -4.00323  1.000 23.99246 ? 479 GLU A OE1 1 
ATOM   171 O OE2 . GLU A 1 22 ? -16.00379 19.37840 -2.36668  1.000 25.39462 ? 479 GLU A OE2 1 
ATOM   172 N N   . HIS A 1 23 ? -19.83111 15.36205 -2.14073  1.000 22.19328 ? 480 HIS A N   1 
ATOM   173 C CA  . HIS A 1 23 ? -19.47994 13.95274 -2.13798  1.000 23.34083 ? 480 HIS A CA  1 
ATOM   174 C C   . HIS A 1 23 ? -20.68695 13.02990 -2.15647  1.000 22.64220 ? 480 HIS A C   1 
ATOM   175 O O   . HIS A 1 23 ? -20.50771 11.81431 -2.22811  1.000 24.16950 ? 480 HIS A O   1 
ATOM   176 C CB  . HIS A 1 23 ? -18.60631 13.64542 -0.91802  1.000 22.44658 ? 480 HIS A CB  1 
ATOM   177 C CG  . HIS A 1 23 ? -17.34863 14.45329 -0.87475  1.000 22.22951 ? 480 HIS A CG  1 
ATOM   178 N ND1 . HIS A 1 23 ? -16.42460 14.43492 -1.89747  1.000 22.25949 ? 480 HIS A ND1 1 
ATOM   179 C CD2 . HIS A 1 23 ? -16.87233 15.32048 0.05074   1.000 20.51088 ? 480 HIS A CD2 1 
ATOM   180 C CE1 . HIS A 1 23 ? -15.42551 15.24715 -1.59764  1.000 22.81969 ? 480 HIS A CE1 1 
ATOM   181 N NE2 . HIS A 1 23 ? -15.67081 15.79516 -0.41929  1.000 23.46030 ? 480 HIS A NE2 1 
ATOM   182 N N   . GLY A 1 24 ? -21.90235 13.56666 -2.09750  1.000 22.52699 ? 481 GLY A N   1 
ATOM   183 C CA  . GLY A 1 24 ? -23.07333 12.71693 -2.24085  1.000 22.69054 ? 481 GLY A CA  1 
ATOM   184 C C   . GLY A 1 24 ? -23.04359 11.88054 -3.50530  1.000 24.75768 ? 481 GLY A C   1 
ATOM   185 O O   . GLY A 1 24 ? -23.39768 10.70088 -3.48609  1.000 24.94449 ? 481 GLY A O   1 
ATOM   186 N N   . LYS A 1 25 ? -22.60212 12.47249 -4.62004  1.000 23.94165 ? 482 LYS A N   1 
ATOM   187 C CA  . LYS A 1 25 ? -22.70289 11.79331 -5.91072  1.000 23.75098 ? 482 LYS A CA  1 
ATOM   188 C C   . LYS A 1 25 ? -21.76639 10.59517 -5.98378  1.000 22.62663 ? 482 LYS A C   1 
ATOM   189 O O   . LYS A 1 25 ? -22.15546 9.52225  -6.46256  1.000 20.91275 ? 482 LYS A O   1 
ATOM   190 C CB  . LYS A 1 25 ? -22.40723 12.76854 -7.05629  1.000 22.29833 ? 482 LYS A CB  1 
ATOM   191 C CG  . LYS A 1 25 ? -22.36246 12.10903 -8.44397  1.000 25.26687 ? 482 LYS A CG  1 
ATOM   192 C CD  . LYS A 1 25 ? -22.51892 13.14693 -9.56114  1.000 24.59045 ? 482 LYS A CD  1 
ATOM   193 C CE  . LYS A 1 25 ? -22.53144 12.51003 -10.96520 1.000 32.24280 ? 482 LYS A CE  1 
ATOM   194 N NZ  . LYS A 1 25 ? -21.69396 11.28376 -11.08189 1.000 30.77694 ? 482 LYS A NZ  1 
ATOM   195 N N   . VAL A 1 26 ? -20.51664 10.76752 -5.53937  1.000 23.09259 ? 483 VAL A N   1 
ATOM   196 C CA  . VAL A 1 26 ? -19.54127 9.68611  -5.66137  1.000 23.35319 ? 483 VAL A CA  1 
ATOM   197 C C   . VAL A 1 26 ? -19.96117 8.48924  -4.81745  1.000 23.94774 ? 483 VAL A C   1 
ATOM   198 O O   . VAL A 1 26 ? -19.79209 7.33778  -5.22951  1.000 22.03120 ? 483 VAL A O   1 
ATOM   199 C CB  . VAL A 1 26 ? -18.12314 10.17693 -5.30163  1.000 24.41102 ? 483 VAL A CB  1 
ATOM   200 C CG1 . VAL A 1 26 ? -18.00862 10.52996 -3.81025  1.000 22.37974 ? 483 VAL A CG1 1 
ATOM   201 C CG2 . VAL A 1 26 ? -17.09238 9.13239  -5.66433  1.000 24.66542 ? 483 VAL A CG2 1 
ATOM   202 N N   . PHE A 1 27 ? -20.51783 8.73247  -3.62720  1.000 22.20575 ? 484 PHE A N   1 
ATOM   203 C CA  . PHE A 1 27 ? -21.01237 7.61723  -2.83083  1.000 22.67880 ? 484 PHE A CA  1 
ATOM   204 C C   . PHE A 1 27 ? -22.17228 6.91785  -3.52383  1.000 23.32446 ? 484 PHE A C   1 
ATOM   205 O O   . PHE A 1 27 ? -22.23963 5.68395  -3.54758  1.000 24.11536 ? 484 PHE A O   1 
ATOM   206 C CB  . PHE A 1 27 ? -21.42413 8.10594  -1.45001  1.000 23.38260 ? 484 PHE A CB  1 
ATOM   207 C CG  . PHE A 1 27 ? -20.28963 8.14156  -0.48703  1.000 25.60296 ? 484 PHE A CG  1 
ATOM   208 C CD1 . PHE A 1 27 ? -19.42470 9.22837  -0.45882  1.000 24.89871 ? 484 PHE A CD1 1 
ATOM   209 C CD2 . PHE A 1 27 ? -20.05679 7.07432  0.35857   1.000 26.53592 ? 484 PHE A CD2 1 
ATOM   210 C CE1 . PHE A 1 27 ? -18.35607 9.25368  0.41901   1.000 25.89097 ? 484 PHE A CE1 1 
ATOM   211 C CE2 . PHE A 1 27 ? -18.98951 7.09689  1.24660   1.000 26.23641 ? 484 PHE A CE2 1 
ATOM   212 C CZ  . PHE A 1 27 ? -18.14573 8.18754  1.27340   1.000 27.20394 ? 484 PHE A CZ  1 
ATOM   213 N N   . LYS A 1 28 ? -23.09797 7.69071  -4.08961  1.000 21.56297 ? 485 LYS A N   1 
ATOM   214 C CA  . LYS A 1 28 ? -24.20263 7.08633  -4.82249  1.000 24.90639 ? 485 LYS A CA  1 
ATOM   215 C C   . LYS A 1 28 ? -23.68771 6.32978  -6.04257  1.000 23.25324 ? 485 LYS A C   1 
ATOM   216 O O   . LYS A 1 28 ? -24.09705 5.18665  -6.29374  1.000 22.89890 ? 485 LYS A O   1 
ATOM   217 C CB  . LYS A 1 28 ? -25.20588 8.17268  -5.21550  1.000 24.10733 ? 485 LYS A CB  1 
ATOM   218 C CG  . LYS A 1 28 ? -26.24595 7.73545  -6.22300  1.000 28.03196 ? 485 LYS A CG  1 
ATOM   219 C CD  . LYS A 1 28 ? -27.32445 6.90376  -5.57293  1.000 25.27746 ? 485 LYS A CD  1 
ATOM   220 C CE  . LYS A 1 28 ? -28.47991 6.65386  -6.52592  1.000 28.48643 ? 485 LYS A CE  1 
ATOM   221 N NZ  . LYS A 1 28 ? -29.54408 5.80296  -5.92234  1.000 29.25401 ? 485 LYS A NZ  1 
ATOM   222 N N   . ASP A 1 29 ? -22.75157 6.93750  -6.78207  1.000 21.65986 ? 486 ASP A N   1 
ATOM   223 C CA  . ASP A 1 29 ? -22.20094 6.30715  -7.97913  1.000 24.83624 ? 486 ASP A CA  1 
ATOM   224 C C   . ASP A 1 29 ? -21.54539 4.96946  -7.66191  1.000 24.76386 ? 486 ASP A C   1 
ATOM   225 O O   . ASP A 1 29 ? -21.63603 4.02884  -8.45790  1.000 23.73081 ? 486 ASP A O   1 
ATOM   226 C CB  . ASP A 1 29 ? -21.18420 7.23057  -8.65224  1.000 24.81826 ? 486 ASP A CB  1 
ATOM   227 C CG  . ASP A 1 29 ? -21.83507 8.37501  -9.39818  1.000 26.50316 ? 486 ASP A CG  1 
ATOM   228 O OD1 . ASP A 1 29 ? -23.04776 8.29399  -9.67182  1.000 23.65850 ? 486 ASP A OD1 1 
ATOM   229 O OD2 . ASP A 1 29 ? -21.13054 9.36073  -9.70204  1.000 29.59991 ? 486 ASP A OD2 1 
ATOM   230 N N   . GLU A 1 30 ? -20.84997 4.87206  -6.53076  1.000 23.48140 ? 487 GLU A N   1 
ATOM   231 C CA  . GLU A 1 30 ? -20.17662 3.63103  -6.16028  1.000 23.36878 ? 487 GLU A CA  1 
ATOM   232 C C   . GLU A 1 30 ? -21.08581 2.66691  -5.41247  1.000 23.65260 ? 487 GLU A C   1 
ATOM   233 O O   . GLU A 1 30 ? -20.59676 1.66674  -4.87164  1.000 23.46995 ? 487 GLU A O   1 
ATOM   234 C CB  . GLU A 1 30 ? -18.93120 3.92518  -5.31967  1.000 23.80956 ? 487 GLU A CB  1 
ATOM   235 C CG  . GLU A 1 30 ? -17.87302 4.70510  -6.05884  1.000 23.00568 ? 487 GLU A CG  1 
ATOM   236 C CD  . GLU A 1 30 ? -17.14275 3.86538  -7.08258  1.000 26.39270 ? 487 GLU A CD  1 
ATOM   237 O OE1 . GLU A 1 30 ? -17.05799 2.62983  -6.90856  1.000 22.56995 ? 487 GLU A OE1 1 
ATOM   238 O OE2 . GLU A 1 30 ? -16.65030 4.44429  -8.06713  1.000 31.12174 ? 487 GLU A OE2 1 
ATOM   239 N N   . GLN A 1 31 ? -22.38609 2.95304  -5.34857  1.000 22.96533 ? 488 GLN A N   1 
ATOM   240 C CA  . GLN A 1 31 ? -23.36194 2.05106  -4.72917  1.000 24.27559 ? 488 GLN A CA  1 
ATOM   241 C C   . GLN A 1 31 ? -23.01546 1.74785  -3.27120  1.000 22.27206 ? 488 GLN A C   1 
ATOM   242 O O   . GLN A 1 31 ? -23.11356 0.60771  -2.80383  1.000 21.11458 ? 488 GLN A O   1 
ATOM   243 C CB  . GLN A 1 31 ? -23.50403 0.76640  -5.55214  1.000 21.81568 ? 488 GLN A CB  1 
ATOM   244 C CG  . GLN A 1 31 ? -23.97026 1.06320  -6.96874  1.000 23.52065 ? 488 GLN A CG  1 
ATOM   245 C CD  . GLN A 1 31 ? -24.17128 -0.18539 -7.81846  1.000 23.58681 ? 488 GLN A CD  1 
ATOM   246 O OE1 . GLN A 1 31 ? -23.89854 -1.30563 -7.38901  1.000 23.55139 ? 488 GLN A OE1 1 
ATOM   247 N NE2 . GLN A 1 31 ? -24.66049 0.00904  -9.02293  1.000 24.19044 ? 488 GLN A NE2 1 
ATOM   248 N N   . ILE A 1 32 ? -22.61157 2.78503  -2.53480  1.000 21.99323 ? 489 ILE A N   1 
ATOM   249 C CA  . ILE A 1 32 ? -22.36641 2.65172  -1.10156  1.000 21.05489 ? 489 ILE A CA  1 
ATOM   250 C C   . ILE A 1 32 ? -23.71230 2.71739  -0.38787  1.000 20.77501 ? 489 ILE A C   1 
ATOM   251 O O   . ILE A 1 32 ? -24.20453 3.80414  -0.08400  1.000 22.89419 ? 489 ILE A O   1 
ATOM   252 C CB  . ILE A 1 32 ? -21.41645 3.72912  -0.57650  1.000 22.40428 ? 489 ILE A CB  1 
ATOM   253 C CG1 . ILE A 1 32 ? -20.18427 3.86125  -1.47983  1.000 22.41174 ? 489 ILE A CG1 1 
ATOM   254 C CG2 . ILE A 1 32 ? -21.06790 3.44215  0.89349   1.000 20.23157 ? 489 ILE A CG2 1 
ATOM   255 C CD1 . ILE A 1 32 ? -19.33780 2.62809  -1.54279  1.000 21.38133 ? 489 ILE A CD1 1 
ATOM   256 N N   . ASP A 1 33 ? -24.30975 1.56419  -0.09875  1.000 20.75284 ? 490 ASP A N   1 
ATOM   257 C CA  . ASP A 1 33 ? -25.44464 1.55886  0.80550   1.000 22.60523 ? 490 ASP A CA  1 
ATOM   258 C C   . ASP A 1 33 ? -24.92280 1.53038  2.24506   1.000 21.61803 ? 490 ASP A C   1 
ATOM   259 O O   . ASP A 1 33 ? -23.71422 1.59562  2.49401   1.000 22.16661 ? 490 ASP A O   1 
ATOM   260 C CB  . ASP A 1 33 ? -26.39329 0.39590  0.49432   1.000 19.82232 ? 490 ASP A CB  1 
ATOM   261 C CG  . ASP A 1 33 ? -25.75955 -0.96447 0.72745   1.000 25.09706 ? 490 ASP A CG  1 
ATOM   262 O OD1 . ASP A 1 33 ? -24.55310 -1.03066 1.04799   1.000 23.07161 ? 490 ASP A OD1 1 
ATOM   263 O OD2 . ASP A 1 33 ? -26.47053 -1.97855 0.57323   1.000 24.03365 ? 490 ASP A OD2 1 
ATOM   264 N N   . GLY A 1 34 ? -25.83969 1.45075  3.21100   1.000 21.17226 ? 491 GLY A N   1 
ATOM   265 C CA  . GLY A 1 34 ? -25.42527 1.49582  4.60726   1.000 22.26147 ? 491 GLY A CA  1 
ATOM   266 C C   . GLY A 1 34 ? -24.52801 0.33604  4.98924   1.000 22.28066 ? 491 GLY A C   1 
ATOM   267 O O   . GLY A 1 34 ? -23.55292 0.50326  5.72988   1.000 22.29497 ? 491 GLY A O   1 
ATOM   268 N N   . GLU A 1 35 ? -24.84589 -0.85844 4.49363   1.000 21.83724 ? 492 GLU A N   1 
ATOM   269 C CA  . GLU A 1 35 ? -24.01799 -2.01909 4.78214   1.000 22.38431 ? 492 GLU A CA  1 
ATOM   270 C C   . GLU A 1 35 ? -22.58496 -1.81610 4.28305   1.000 23.36969 ? 492 GLU A C   1 
ATOM   271 O O   . GLU A 1 35 ? -21.62368 -2.06520 5.01835   1.000 24.36824 ? 492 GLU A O   1 
ATOM   272 C CB  . GLU A 1 35 ? -24.65296 -3.26631 4.16329   1.000 25.04512 ? 492 GLU A CB  1 
ATOM   273 C CG  . GLU A 1 35 ? -23.78358 -4.51420 4.23086   1.000 27.64259 ? 492 GLU A CG  1 
ATOM   274 C CD  . GLU A 1 35 ? -24.54697 -5.78086 3.86505   1.000 31.89880 ? 492 GLU A CD  1 
ATOM   275 O OE1 . GLU A 1 35 ? -25.79162 -5.78303 3.98397   1.000 37.43802 ? 492 GLU A OE1 1 
ATOM   276 O OE2 . GLU A 1 35 ? -23.90430 -6.77568 3.46841   1.000 33.42113 ? 492 GLU A OE2 1 
ATOM   277 N N   . ALA A 1 36 ? -22.41888 -1.33847 3.04787   1.000 20.17118 ? 493 ALA A N   1 
ATOM   278 C CA  . ALA A 1 36 ? -21.07367 -1.07809 2.54171   1.000 21.08741 ? 493 ALA A CA  1 
ATOM   279 C C   . ALA A 1 36 ? -20.42588 0.08925  3.27326   1.000 21.63703 ? 493 ALA A C   1 
ATOM   280 O O   . ALA A 1 36 ? -19.21096 0.08715  3.50740   1.000 20.80551 ? 493 ALA A O   1 
ATOM   281 C CB  . ALA A 1 36 ? -21.12096 -0.80362 1.03706   1.000 22.05245 ? 493 ALA A CB  1 
ATOM   282 N N   . PHE A 1 37 ? -21.22546 1.09643  3.63413   1.000 21.01325 ? 494 PHE A N   1 
ATOM   283 C CA  . PHE A 1 37 ? -20.70711 2.27937  4.31606   1.000 22.12759 ? 494 PHE A CA  1 
ATOM   284 C C   . PHE A 1 37 ? -19.94869 1.89722  5.58057   1.000 22.89271 ? 494 PHE A C   1 
ATOM   285 O O   . PHE A 1 37 ? -18.85729 2.41301  5.83707   1.000 24.31539 ? 494 PHE A O   1 
ATOM   286 C CB  . PHE A 1 37 ? -21.86940 3.22864  4.63563   1.000 21.57353 ? 494 PHE A CB  1 
ATOM   287 C CG  . PHE A 1 37 ? -21.44691 4.57198  5.18133   1.000 23.20378 ? 494 PHE A CG  1 
ATOM   288 C CD1 . PHE A 1 37 ? -20.40709 5.28324  4.60257   1.000 22.80395 ? 494 PHE A CD1 1 
ATOM   289 C CD2 . PHE A 1 37 ? -22.10808 5.12640  6.26266   1.000 23.04712 ? 494 PHE A CD2 1 
ATOM   290 C CE1 . PHE A 1 37 ? -20.02586 6.51720  5.09533   1.000 23.38383 ? 494 PHE A CE1 1 
ATOM   291 C CE2 . PHE A 1 37 ? -21.73387 6.36730  6.76300   1.000 26.62168 ? 494 PHE A CE2 1 
ATOM   292 C CZ  . PHE A 1 37 ? -20.69359 7.06439  6.17154   1.000 23.48190 ? 494 PHE A CZ  1 
ATOM   293 N N   . LEU A 1 38 ? -20.49084 0.95694  6.35620   1.000 22.68226 ? 495 LEU A N   1 
ATOM   294 C CA  . LEU A 1 38 ? -19.88562 0.54486  7.61910   1.000 24.24431 ? 495 LEU A CA  1 
ATOM   295 C C   . LEU A 1 38 ? -18.65177 -0.32761 7.43633   1.000 26.16378 ? 495 LEU A C   1 
ATOM   296 O O   . LEU A 1 38 ? -17.93135 -0.55622 8.41465   1.000 25.62887 ? 495 LEU A O   1 
ATOM   297 C CB  . LEU A 1 38 ? -20.90833 -0.20278 8.47348   1.000 23.86190 ? 495 LEU A CB  1 
ATOM   298 C CG  . LEU A 1 38 ? -22.05214 0.66184  9.01286   1.000 27.24996 ? 495 LEU A CG  1 
ATOM   299 C CD1 . LEU A 1 38 ? -23.02156 -0.16661 9.84382   1.000 25.05458 ? 495 LEU A CD1 1 
ATOM   300 C CD2 . LEU A 1 38 ? -21.49633 1.81683  9.82515   1.000 27.24873 ? 495 LEU A CD2 1 
ATOM   301 N N   . LEU A 1 39 ? -18.38739 -0.80564 6.22208   1.000 22.17098 ? 496 LEU A N   1 
ATOM   302 C CA  . LEU A 1 39 ? -17.18173 -1.56932 5.92660   1.000 23.80548 ? 496 LEU A CA  1 
ATOM   303 C C   . LEU A 1 39 ? -16.03233 -0.70798 5.42338   1.000 23.95359 ? 496 LEU A C   1 
ATOM   304 O O   . LEU A 1 39 ? -14.91927 -1.22011 5.26934   1.000 23.44798 ? 496 LEU A O   1 
ATOM   305 C CB  . LEU A 1 39 ? -17.49041 -2.64875 4.88191   1.000 21.38350 ? 496 LEU A CB  1 
ATOM   306 C CG  . LEU A 1 39 ? -18.58872 -3.62060 5.31218   1.000 22.77011 ? 496 LEU A CG  1 
ATOM   307 C CD1 . LEU A 1 39 ? -19.02542 -4.49492 4.16004   1.000 23.53786 ? 496 LEU A CD1 1 
ATOM   308 C CD2 . LEU A 1 39 ? -18.09978 -4.47643 6.45781   1.000 25.48057 ? 496 LEU A CD2 1 
ATOM   309 N N   . MET A 1 40 ? -16.27249 0.57063  5.15575   1.000 22.17016 ? 497 MET A N   1 
ATOM   310 C CA  . MET A 1 40 ? -15.26707 1.40910  4.51188   1.000 23.84539 ? 497 MET A CA  1 
ATOM   311 C C   . MET A 1 40 ? -14.12133 1.71875  5.46107   1.000 25.09499 ? 497 MET A C   1 
ATOM   312 O O   . MET A 1 40 ? -14.33439 1.94288  6.65569   1.000 23.46340 ? 497 MET A O   1 
ATOM   313 C CB  . MET A 1 40 ? -15.89107 2.72419  4.05065   1.000 22.15587 ? 497 MET A CB  1 
ATOM   314 C CG  . MET A 1 40 ? -16.89269 2.57789  2.94407   1.000 25.74931 ? 497 MET A CG  1 
ATOM   315 S SD  . MET A 1 40 ? -17.42172 4.18958  2.33582   1.000 29.27292 ? 497 MET A SD  1 
ATOM   316 C CE  . MET A 1 40 ? -16.02099 4.63842  1.31470   1.000 26.14568 ? 497 MET A CE  1 
ATOM   317 N N   . THR A 1 41 ? -12.90362 1.75528  4.92304   1.000 22.98093 ? 498 THR A N   1 
ATOM   318 C CA  . THR A 1 41 ? -11.76188 2.26661  5.66680   1.000 23.69279 ? 498 THR A CA  1 
ATOM   319 C C   . THR A 1 41 ? -11.47618 3.70357  5.25212   1.000 23.22073 ? 498 THR A C   1 
ATOM   320 O O   . THR A 1 41 ? -12.02350 4.21925  4.27628   1.000 25.27010 ? 498 THR A O   1 
ATOM   321 C CB  . THR A 1 41 ? -10.50728 1.42458  5.43349   1.000 24.52350 ? 498 THR A CB  1 
ATOM   322 O OG1 . THR A 1 41 ? -10.09376 1.59005  4.07396   1.000 24.64871 ? 498 THR A OG1 1 
ATOM   323 C CG2 . THR A 1 41 ? -10.76988 -0.05134 5.73272   1.000 26.22870 ? 498 THR A CG2 1 
ATOM   324 N N   . GLN A 1 42 ? -10.56832 4.33831  5.99334   1.000 23.28748 ? 499 GLN A N   1 
ATOM   325 C CA  . GLN A 1 42 ? -10.15236 5.68786  5.63396   1.000 25.20408 ? 499 GLN A CA  1 
ATOM   326 C C   . GLN A 1 42 ? -9.46195  5.69787  4.28051   1.000 22.58778 ? 499 GLN A C   1 
ATOM   327 O O   . GLN A 1 42 ? -9.71999  6.57601  3.45184   1.000 23.40882 ? 499 GLN A O   1 
ATOM   328 C CB  . GLN A 1 42 ? -9.23096  6.26982  6.70515   1.000 23.51900 ? 499 GLN A CB  1 
ATOM   329 C CG  . GLN A 1 42 ? -8.79220  7.68986  6.39194   1.000 25.97661 ? 499 GLN A CG  1 
ATOM   330 C CD  . GLN A 1 42 ? -7.98290  8.30637  7.51404   1.000 30.03643 ? 499 GLN A CD  1 
ATOM   331 O OE1 . GLN A 1 42 ? -6.87739  8.79781  7.29487   1.000 31.76003 ? 499 GLN A OE1 1 
ATOM   332 N NE2 . GLN A 1 42 ? -8.53080  8.28628  8.72354   1.000 27.86320 ? 499 GLN A NE2 1 
ATOM   333 N N   . THR A 1 43 ? -8.58731  4.71989  4.03371   1.000 24.32491 ? 500 THR A N   1 
ATOM   334 C CA  . THR A 1 43 ? -7.90791  4.63817  2.74210   1.000 24.83475 ? 500 THR A CA  1 
ATOM   335 C C   . THR A 1 43 ? -8.89981  4.45699  1.59872   1.000 22.99369 ? 500 THR A C   1 
ATOM   336 O O   . THR A 1 43 ? -8.71151  5.01901  0.51048   1.000 24.43274 ? 500 THR A O   1 
ATOM   337 C CB  . THR A 1 43 ? -6.89439  3.49848  2.76933   1.000 26.41045 ? 500 THR A CB  1 
ATOM   338 O OG1 . THR A 1 43 ? -5.95536  3.74208  3.82044   1.000 32.15138 ? 500 THR A OG1 1 
ATOM   339 C CG2 . THR A 1 43 ? -6.14243  3.41900  1.46346   1.000 27.98212 ? 500 THR A CG2 1 
ATOM   340 N N   . ASP A 1 44 ? -9.96245  3.67576  1.82314   1.000 21.17134 ? 501 ASP A N   1 
ATOM   341 C CA  . ASP A 1 44 ? -11.03452 3.57153  0.83511   1.000 22.31964 ? 501 ASP A CA  1 
ATOM   342 C C   . ASP A 1 44 ? -11.54520 4.95547  0.45454   1.000 24.66915 ? 501 ASP A C   1 
ATOM   343 O O   . ASP A 1 44 ? -11.69963 5.27509  -0.73116  1.000 22.99987 ? 501 ASP A O   1 
ATOM   344 C CB  . ASP A 1 44 ? -12.19918 2.73211  1.38298   1.000 22.74868 ? 501 ASP A CB  1 
ATOM   345 C CG  . ASP A 1 44 ? -11.87959 1.25428  1.49010   1.000 24.08217 ? 501 ASP A CG  1 
ATOM   346 O OD1 . ASP A 1 44 ? -11.04140 0.75043  0.71174   1.000 25.68443 ? 501 ASP A OD1 1 
ATOM   347 O OD2 . ASP A 1 44 ? -12.50158 0.58668  2.34688   1.000 25.79272 ? 501 ASP A OD2 1 
ATOM   348 N N   . ILE A 1 45 ? -11.81256 5.78954  1.46433   1.000 21.29610 ? 502 ILE A N   1 
ATOM   349 C CA  . ILE A 1 45 ? -12.38216 7.11564  1.23441   1.000 21.68764 ? 502 ILE A CA  1 
ATOM   350 C C   . ILE A 1 45 ? -11.36212 8.03165  0.56892   1.000 21.75266 ? 502 ILE A C   1 
ATOM   351 O O   . ILE A 1 45 ? -11.67851 8.74571  -0.38686  1.000 23.09982 ? 502 ILE A O   1 
ATOM   352 C CB  . ILE A 1 45 ? -12.87918 7.72322  2.56022   1.000 19.82473 ? 502 ILE A CB  1 
ATOM   353 C CG1 . ILE A 1 45 ? -13.96197 6.84727  3.21151   1.000 21.54761 ? 502 ILE A CG1 1 
ATOM   354 C CG2 . ILE A 1 45 ? -13.37919 9.15826  2.34611   1.000 20.68626 ? 502 ILE A CG2 1 
ATOM   355 C CD1 . ILE A 1 45 ? -14.21516 7.17749  4.69363   1.000 21.78164 ? 502 ILE A CD1 1 
ATOM   356 N N   . VAL A 1 46 ? -10.12904 8.04141  1.07708   1.000 20.99577 ? 503 VAL A N   1 
ATOM   357 C CA  . VAL A 1 46 ? -9.13559  8.99644  0.58906   1.000 24.19105 ? 503 VAL A CA  1 
ATOM   358 C C   . VAL A 1 46 ? -8.65361  8.60452  -0.79823  1.000 25.16771 ? 503 VAL A C   1 
ATOM   359 O O   . VAL A 1 46 ? -8.62987  9.42676  -1.72275  1.000 25.69298 ? 503 VAL A O   1 
ATOM   360 C CB  . VAL A 1 46 ? -7.95933  9.10183  1.57548   1.000 26.50304 ? 503 VAL A CB  1 
ATOM   361 C CG1 . VAL A 1 46 ? -6.81213  9.87672  0.94954   1.000 28.33202 ? 503 VAL A CG1 1 
ATOM   362 C CG2 . VAL A 1 46 ? -8.41009  9.76580  2.85884   1.000 24.09731 ? 503 VAL A CG2 1 
ATOM   363 N N   . LYS A 1 47 ? -8.26918  7.34278  -0.96635  1.000 26.15975 ? 504 LYS A N   1 
ATOM   364 C CA  . LYS A 1 47 ? -7.61374  6.90517  -2.19143  1.000 25.45333 ? 504 LYS A CA  1 
ATOM   365 C C   . LYS A 1 47 ? -8.61181  6.43162  -3.24445  1.000 26.18535 ? 504 LYS A C   1 
ATOM   366 O O   . LYS A 1 47 ? -8.59768  6.90821  -4.38548  1.000 27.40022 ? 504 LYS A O   1 
ATOM   367 C CB  . LYS A 1 47 ? -6.60380  5.79604  -1.86442  1.000 28.75842 ? 504 LYS A CB  1 
ATOM   368 C CG  . LYS A 1 47 ? -5.28667  6.29859  -1.27386  1.000 30.72888 ? 504 LYS A CG  1 
ATOM   369 C CD  . LYS A 1 47 ? -5.41464  6.59541  0.21104   1.000 35.09509 ? 504 LYS A CD  1 
ATOM   370 C CE  . LYS A 1 47 ? -4.06231  6.65754  0.93769   1.000 40.19359 ? 504 LYS A CE  1 
ATOM   371 N NZ  . LYS A 1 47 ? -4.23435  7.09791  2.35969   1.000 37.77051 ? 504 LYS A NZ  1 
ATOM   372 N N   . ILE A 1 48 ? -9.49154  5.49861  -2.88863  1.000 25.24510 ? 505 ILE A N   1 
ATOM   373 C CA  . ILE A 1 48 ? -10.38402 4.94341  -3.89917  1.000 24.57333 ? 505 ILE A CA  1 
ATOM   374 C C   . ILE A 1 48 ? -11.44170 5.96208  -4.31029  1.000 26.30638 ? 505 ILE A C   1 
ATOM   375 O O   . ILE A 1 48 ? -11.74291 6.11960  -5.50027  1.000 24.60419 ? 505 ILE A O   1 
ATOM   376 C CB  . ILE A 1 48 ? -10.99374 3.62746  -3.38755  1.000 24.51904 ? 505 ILE A CB  1 
ATOM   377 C CG1 . ILE A 1 48 ? -9.87351  2.58947  -3.24642  1.000 26.37547 ? 505 ILE A CG1 1 
ATOM   378 C CG2 . ILE A 1 48 ? -12.06109 3.12396  -4.33766  1.000 23.52156 ? 505 ILE A CG2 1 
ATOM   379 C CD1 . ILE A 1 48 ? -10.31227 1.26841  -2.67326  1.000 28.43191 ? 505 ILE A CD1 1 
ATOM   380 N N   . MET A 1 49 ? -12.00270 6.69013  -3.35421  1.000 26.19161 ? 506 MET A N   1 
ATOM   381 C CA  . MET A 1 49 ? -13.03388 7.66574  -3.68219  1.000 26.31571 ? 506 MET A CA  1 
ATOM   382 C C   . MET A 1 49 ? -12.47896 9.04807  -3.99787  1.000 25.18735 ? 506 MET A C   1 
ATOM   383 O O   . MET A 1 49 ? -13.25720 9.94036  -4.35311  1.000 26.32683 ? 506 MET A O   1 
ATOM   384 C CB  . MET A 1 49 ? -14.03188 7.76454  -2.53757  1.000 24.48943 ? 506 MET A CB  1 
ATOM   385 C CG  . MET A 1 49 ? -14.74008 6.46144  -2.30130  1.000 29.82055 ? 506 MET A CG  1 
ATOM   386 S SD  . MET A 1 49 ? -16.35314 6.77954  -1.64334  1.000 49.49691 ? 506 MET A SD  1 
ATOM   387 C CE  . MET A 1 49 ? -17.38542 6.19872  -2.94181  1.000 29.41829 ? 506 MET A CE  1 
ATOM   388 N N   . SER A 1 50 ? -11.16528 9.24017  -3.87478  1.000 26.11770 ? 507 SER A N   1 
ATOM   389 C CA  . SER A 1 50 ? -10.49731 10.49569 -4.22233  1.000 24.66089 ? 507 SER A CA  1 
ATOM   390 C C   . SER A 1 50 ? -11.06902 11.67210 -3.43403  1.000 26.39208 ? 507 SER A C   1 
ATOM   391 O O   . SER A 1 50 ? -11.36299 12.72951 -3.99112  1.000 27.24393 ? 507 SER A O   1 
ATOM   392 C CB  . SER A 1 50 ? -10.57948 10.76471 -5.72821  1.000 28.31852 ? 507 SER A CB  1 
ATOM   393 O OG  . SER A 1 50 ? -10.02969 9.68740  -6.46214  1.000 35.83542 ? 507 SER A OG  1 
ATOM   394 N N   . ILE A 1 51 ? -11.21428 11.49115 -2.12103  1.000 21.74429 ? 508 ILE A N   1 
ATOM   395 C CA  . ILE A 1 51 ? -11.75305 12.52717 -1.24382  1.000 22.75025 ? 508 ILE A CA  1 
ATOM   396 C C   . ILE A 1 51 ? -10.62561 13.08808 -0.38693  1.000 21.81925 ? 508 ILE A C   1 
ATOM   397 O O   . ILE A 1 51 ? -9.78390  12.33507 0.11561   1.000 21.46352 ? 508 ILE A O   1 
ATOM   398 C CB  . ILE A 1 51 ? -12.90575 11.96983 -0.38296  1.000 21.70283 ? 508 ILE A CB  1 
ATOM   399 C CG1 . ILE A 1 51 ? -14.12187 11.69322 -1.27588  1.000 21.95081 ? 508 ILE A CG1 1 
ATOM   400 C CG2 . ILE A 1 51 ? -13.26514 12.91975 0.74902   1.000 21.94903 ? 508 ILE A CG2 1 
ATOM   401 C CD1 . ILE A 1 51 ? -15.24717 10.96840 -0.57779  1.000 23.74798 ? 508 ILE A CD1 1 
ATOM   402 N N   . LYS A 1 52 ? -10.60089 14.41077 -0.22565  1.000 18.92710 ? 509 LYS A N   1 
ATOM   403 C CA  . LYS A 1 52 ? -9.53358  15.04062 0.54672   1.000 21.53484 ? 509 LYS A CA  1 
ATOM   404 C C   . LYS A 1 52 ? -9.61615  14.65741 2.02474   1.000 20.68307 ? 509 LYS A C   1 
ATOM   405 O O   . LYS A 1 52 ? -10.65024 14.21582 2.52184   1.000 20.32431 ? 509 LYS A O   1 
ATOM   406 C CB  . LYS A 1 52 ? -9.58776  16.55424 0.39316   1.000 20.35432 ? 509 LYS A CB  1 
ATOM   407 C CG  . LYS A 1 52 ? -9.40695  16.97883 -1.03636  1.000 22.18786 ? 509 LYS A CG  1 
ATOM   408 C CD  . LYS A 1 52 ? -8.64028  18.24107 -1.11095  1.000 25.20494 ? 509 LYS A CD  1 
ATOM   409 C CE  . LYS A 1 52 ? -9.47979  19.33405 -1.67846  1.000 28.13493 ? 509 LYS A CE  1 
ATOM   410 N NZ  . LYS A 1 52 ? -8.73748  20.08856 -2.74568  1.000 22.61728 ? 509 LYS A NZ  1 
ATOM   411 N N   . LEU A 1 53 ? -8.49417  14.84703 2.72950   1.000 21.52043 ? 510 LEU A N   1 
ATOM   412 C CA  . LEU A 1 53 ? -8.36267  14.33975 4.09562   1.000 20.28246 ? 510 LEU A CA  1 
ATOM   413 C C   . LEU A 1 53 ? -9.39924  14.94604 5.03267   1.000 21.20617 ? 510 LEU A C   1 
ATOM   414 O O   . LEU A 1 53 ? -9.94649  14.25337 5.89522   1.000 18.37891 ? 510 LEU A O   1 
ATOM   415 C CB  . LEU A 1 53 ? -6.95733  14.62252 4.62174   1.000 20.65948 ? 510 LEU A CB  1 
ATOM   416 C CG  . LEU A 1 53 ? -6.65000  14.04205 6.00360   1.000 21.52125 ? 510 LEU A CG  1 
ATOM   417 C CD1 . LEU A 1 53 ? -6.95824  12.55416 6.03162   1.000 21.99869 ? 510 LEU A CD1 1 
ATOM   418 C CD2 . LEU A 1 53 ? -5.20141  14.29946 6.38855   1.000 20.50065 ? 510 LEU A CD2 1 
ATOM   419 N N   . GLY A 1 54 ? -9.66019  16.24004 4.89790   1.000 19.89654 ? 511 GLY A N   1 
ATOM   420 C CA  . GLY A 1 54 ? -10.62602 16.91666 5.72774   1.000 21.66319 ? 511 GLY A CA  1 
ATOM   421 C C   . GLY A 1 54 ? -11.98245 16.24932 5.70531   1.000 20.90333 ? 511 GLY A C   1 
ATOM   422 O O   . GLY A 1 54 ? -12.45697 15.73523 6.71881   1.000 20.56034 ? 511 GLY A O   1 
ATOM   423 N N   . PRO A 1 55 ? -12.64636 16.25369 4.54776   1.000 21.73633 ? 512 PRO A N   1 
ATOM   424 C CA  . PRO A 1 55 ? -13.94138 15.56656 4.46780   1.000 20.73209 ? 512 PRO A CA  1 
ATOM   425 C C   . PRO A 1 55 ? -13.82733 14.08225 4.73674   1.000 21.39989 ? 512 PRO A C   1 
ATOM   426 O O   . PRO A 1 55 ? -14.72899 13.50393 5.35340   1.000 20.38712 ? 512 PRO A O   1 
ATOM   427 C CB  . PRO A 1 55 ? -14.41647 15.85878 3.03465   1.000 22.62291 ? 512 PRO A CB  1 
ATOM   428 C CG  . PRO A 1 55 ? -13.18895 16.29876 2.28341   1.000 22.55221 ? 512 PRO A CG  1 
ATOM   429 C CD  . PRO A 1 55 ? -12.31859 16.97580 3.30577   1.000 22.39322 ? 512 PRO A CD  1 
ATOM   430 N N   . ALA A 1 56 ? -12.73058 13.45011 4.31354   1.000 20.90539 ? 513 ALA A N   1 
ATOM   431 C CA  . ALA A 1 56 ? -12.55145 12.03338 4.59740   1.000 21.93504 ? 513 ALA A CA  1 
ATOM   432 C C   . ALA A 1 56 ? -12.55839 11.77100 6.09999   1.000 21.96640 ? 513 ALA A C   1 
ATOM   433 O O   . ALA A 1 56 ? -13.12634 10.77387 6.56164   1.000 19.93715 ? 513 ALA A O   1 
ATOM   434 C CB  . ALA A 1 56 ? -11.25116 11.53328 3.97128   1.000 21.28080 ? 513 ALA A CB  1 
ATOM   435 N N   . LEU A 1 57 ? -11.93948 12.65970 6.88259   1.000 21.88358 ? 514 LEU A N   1 
ATOM   436 C CA  . LEU A 1 57 ? -11.89209 12.44853 8.32552   1.000 22.49005 ? 514 LEU A CA  1 
ATOM   437 C C   . LEU A 1 57 ? -13.27720 12.54931 8.94576   1.000 21.13085 ? 514 LEU A C   1 
ATOM   438 O O   . LEU A 1 57 ? -13.61057 11.78486 9.85732   1.000 21.81875 ? 514 LEU A O   1 
ATOM   439 C CB  . LEU A 1 57 ? -10.94518 13.45413 8.97700   1.000 22.99011 ? 514 LEU A CB  1 
ATOM   440 C CG  . LEU A 1 57 ? -9.46023  13.11307 8.85387   1.000 21.63893 ? 514 LEU A CG  1 
ATOM   441 C CD1 . LEU A 1 57 ? -8.59864  14.30287 9.21796   1.000 20.28102 ? 514 LEU A CD1 1 
ATOM   442 C CD2 . LEU A 1 57 ? -9.13334  11.89925 9.72605   1.000 22.74868 ? 514 LEU A CD2 1 
ATOM   443 N N   . LYS A 1 58 ? -14.09634 13.48708 8.47127   1.000 21.16936 ? 515 LYS A N   1 
ATOM   444 C CA  . LYS A 1 58 ? -15.45361 13.60130 8.99703   1.000 22.95759 ? 515 LYS A CA  1 
ATOM   445 C C   . LYS A 1 58 ? -16.28401 12.38303 8.63106   1.000 23.48610 ? 515 LYS A C   1 
ATOM   446 O O   . LYS A 1 58 ? -17.04755 11.86755 9.46077   1.000 22.46640 ? 515 LYS A O   1 
ATOM   447 C CB  . LYS A 1 58 ? -16.11990 14.86749 8.46669   1.000 23.35162 ? 515 LYS A CB  1 
ATOM   448 C CG  . LYS A 1 58 ? -15.37605 16.14348 8.81896   1.000 24.11596 ? 515 LYS A CG  1 
ATOM   449 C CD  . LYS A 1 58 ? -15.75513 17.26965 7.86935   1.000 23.92165 ? 515 LYS A CD  1 
ATOM   450 C CE  . LYS A 1 58 ? -15.42586 18.62205 8.47145   1.000 26.44708 ? 515 LYS A CE  1 
ATOM   451 N NZ  . LYS A 1 58 ? -15.59453 19.71154 7.47303   1.000 26.13591 ? 515 LYS A NZ  1 
ATOM   452 N N   . ILE A 1 59 ? -16.15329 11.92121 7.38815   1.000 20.41920 ? 516 ILE A N   1 
ATOM   453 C CA  . ILE A 1 59 ? -16.87656 10.73727 6.94000   1.000 19.97098 ? 516 ILE A CA  1 
ATOM   454 C C   . ILE A 1 59 ? -16.44208 9.51956  7.73838   1.000 22.53778 ? 516 ILE A C   1 
ATOM   455 O O   . ILE A 1 59 ? -17.27119 8.75399  8.24432   1.000 20.76848 ? 516 ILE A O   1 
ATOM   456 C CB  . ILE A 1 59 ? -16.65307 10.51753 5.43465   1.000 22.28509 ? 516 ILE A CB  1 
ATOM   457 C CG1 . ILE A 1 59 ? -17.22118 11.69654 4.64091   1.000 22.74580 ? 516 ILE A CG1 1 
ATOM   458 C CG2 . ILE A 1 59 ? -17.29555 9.20483  5.00016   1.000 22.98259 ? 516 ILE A CG2 1 
ATOM   459 C CD1 . ILE A 1 59 ? -16.69644 11.77604 3.19697   1.000 23.75577 ? 516 ILE A CD1 1 
ATOM   460 N N   . PHE A 1 60 ? -15.12779 9.30950  7.84734   1.000 19.71475 ? 517 PHE A N   1 
ATOM   461 C CA  . PHE A 1 60 ? -14.64980 8.09473  8.49092   1.000 20.65045 ? 517 PHE A CA  1 
ATOM   462 C C   . PHE A 1 60 ? -15.00921 8.10084  9.96867   1.000 21.79359 ? 517 PHE A C   1 
ATOM   463 O O   . PHE A 1 60 ? -15.45002 7.08068  10.50615  1.000 21.14366 ? 517 PHE A O   1 
ATOM   464 C CB  . PHE A 1 60 ? -13.14111 7.94797  8.28529   1.000 20.68057 ? 517 PHE A CB  1 
ATOM   465 C CG  . PHE A 1 60 ? -12.56612 6.68094  8.86920   1.000 22.44350 ? 517 PHE A CG  1 
ATOM   466 C CD1 . PHE A 1 60 ? -13.04249 5.44145  8.47655   1.000 23.84074 ? 517 PHE A CD1 1 
ATOM   467 C CD2 . PHE A 1 60 ? -11.54120 6.73290  9.79375   1.000 22.39008 ? 517 PHE A CD2 1 
ATOM   468 C CE1 . PHE A 1 60 ? -12.50840 4.27139  9.01084   1.000 25.84371 ? 517 PHE A CE1 1 
ATOM   469 C CE2 . PHE A 1 60 ? -11.00687 5.56987  10.33084  1.000 25.21209 ? 517 PHE A CE2 1 
ATOM   470 C CZ  . PHE A 1 60 ? -11.49016 4.34281  9.94064   1.000 23.90057 ? 517 PHE A CZ  1 
ATOM   471 N N   . ASN A 1 61 ? -14.87248 9.25416  10.62734  1.000 20.70617 ? 518 ASN A N   1 
ATOM   472 C CA  . ASN A 1 61 ? -15.26476 9.34901  12.03239  1.000 22.82643 ? 518 ASN A CA  1 
ATOM   473 C C   . ASN A 1 61 ? -16.73326 8.99810  12.21948  1.000 22.83948 ? 518 ASN A C   1 
ATOM   474 O O   . ASN A 1 61 ? -17.10169 8.34131  13.19869  1.000 24.38810 ? 518 ASN A O   1 
ATOM   475 C CB  . ASN A 1 61 ? -14.98295 10.74972 12.56952  1.000 24.45758 ? 518 ASN A CB  1 
ATOM   476 C CG  . ASN A 1 61 ? -15.47002 10.93406 14.00558  1.000 29.50679 ? 518 ASN A CG  1 
ATOM   477 O OD1 . ASN A 1 61 ? -14.93103 10.33417 14.93249  1.000 30.32581 ? 518 ASN A OD1 1 
ATOM   478 N ND2 . ASN A 1 61 ? -16.49566 11.76615 14.18788  1.000 28.93615 ? 518 ASN A ND2 1 
ATOM   479 N N   . SER A 1 62 ? -17.58701 9.40587  11.27891  1.000 23.87609 ? 519 SER A N   1 
ATOM   480 C CA  . SER A 1 62 ? -18.99097 9.01944  11.35548  1.000 24.78338 ? 519 SER A CA  1 
ATOM   481 C C   . SER A 1 62 ? -19.15473 7.50413  11.24573  1.000 24.61847 ? 519 SER A C   1 
ATOM   482 O O   . SER A 1 62 ? -19.89658 6.89730  12.02374  1.000 23.16084 ? 519 SER A O   1 
ATOM   483 C CB  . SER A 1 62 ? -19.79191 9.75032  10.28097  1.000 25.31667 ? 519 SER A CB  1 
ATOM   484 O OG  . SER A 1 62 ? -19.98416 11.10677 10.66918  1.000 27.04420 ? 519 SER A OG  1 
ATOM   485 N N   . ILE A 1 63 ? -18.45952 6.87228  10.29115  1.000 23.04688 ? 520 ILE A N   1 
ATOM   486 C CA  . ILE A 1 63 ? -18.47057 5.40865  10.20522  1.000 23.10665 ? 520 ILE A CA  1 
ATOM   487 C C   . ILE A 1 63 ? -18.10389 4.79395  11.55518  1.000 24.96009 ? 520 ILE A C   1 
ATOM   488 O O   . ILE A 1 63 ? -18.80320 3.91515  12.07082  1.000 23.41821 ? 520 ILE A O   1 
ATOM   489 C CB  . ILE A 1 63 ? -17.51636 4.92804  9.09704   1.000 24.97731 ? 520 ILE A CB  1 
ATOM   490 C CG1 . ILE A 1 63 ? -18.09998 5.23996  7.71589   1.000 25.14572 ? 520 ILE A CG1 1 
ATOM   491 C CG2 . ILE A 1 63 ? -17.23321 3.42882  9.23547   1.000 23.21518 ? 520 ILE A CG2 1 
ATOM   492 C CD1 . ILE A 1 63 ? -17.06960 5.21466  6.59348   1.000 25.74555 ? 520 ILE A CD1 1 
ATOM   493 N N   . LEU A 1 64 ? -17.00676 5.26711  12.15604  1.000 21.86517 ? 521 LEU A N   1 
ATOM   494 C CA  . LEU A 1 64 ? -16.53877 4.68219  13.40776  1.000 23.23202 ? 521 LEU A CA  1 
ATOM   495 C C   . LEU A 1 64 ? -17.57680 4.82527  14.51052  1.000 22.30143 ? 521 LEU A C   1 
ATOM   496 O O   . LEU A 1 64 ? -17.78727 3.89720  15.29684  1.000 23.61926 ? 521 LEU A O   1 
ATOM   497 C CB  . LEU A 1 64 ? -15.21913 5.32683  13.82603  1.000 23.75816 ? 521 LEU A CB  1 
ATOM   498 C CG  . LEU A 1 64 ? -14.03742 4.95463  12.93805  1.000 21.49205 ? 521 LEU A CG  1 
ATOM   499 C CD1 . LEU A 1 64 ? -12.80265 5.67698  13.37505  1.000 24.41181 ? 521 LEU A CD1 1 
ATOM   500 C CD2 . LEU A 1 64 ? -13.82299 3.45687  12.96763  1.000 24.54222 ? 521 LEU A CD2 1 
ATOM   501 N N   . MET A 1 65 ? -18.23516 5.97979  14.58584  1.000 22.45874 ? 522 MET A N   1 
ATOM   502 C CA  . MET A 1 65 ? -19.26521 6.16477  15.60274  1.000 24.28241 ? 522 MET A CA  1 
ATOM   503 C C   . MET A 1 65 ? -20.45690 5.25538  15.35148  1.000 24.97910 ? 522 MET A C   1 
ATOM   504 O O   . MET A 1 65 ? -21.03748 4.70134  16.29379  1.000 23.91138 ? 522 MET A O   1 
ATOM   505 C CB  . MET A 1 65 ? -19.71284 7.62101  15.63717  1.000 24.73654 ? 522 MET A CB  1 
ATOM   506 C CG  . MET A 1 65 ? -18.68605 8.54282  16.24317  1.000 30.03885 ? 522 MET A CG  1 
ATOM   507 S SD  . MET A 1 65 ? -19.24064 10.25470 16.29874  1.000 42.25084 ? 522 MET A SD  1 
ATOM   508 C CE  . MET A 1 65 ? -19.87116 10.50328 14.63844  1.000 32.91823 ? 522 MET A CE  1 
ATOM   509 N N   . PHE A 1 66 ? -20.83432 5.08399  14.08700  1.000 22.55676 ? 523 PHE A N   1 
ATOM   510 C CA  . PHE A 1 66 ? -22.01067 4.27808  13.79105  1.000 23.56018 ? 523 PHE A CA  1 
ATOM   511 C C   . PHE A 1 66 ? -21.73393 2.80241  14.04458  1.000 22.90419 ? 523 PHE A C   1 
ATOM   512 O O   . PHE A 1 66 ? -22.61270 2.07478  14.52193  1.000 23.48116 ? 523 PHE A O   1 
ATOM   513 C CB  . PHE A 1 66 ? -22.46749 4.51879  12.35114  1.000 21.49235 ? 523 PHE A CB  1 
ATOM   514 C CG  . PHE A 1 66 ? -22.80969 5.95799  12.04825  1.000 23.66426 ? 523 PHE A CG  1 
ATOM   515 C CD1 . PHE A 1 66 ? -23.01746 6.87639  13.07290  1.000 23.64625 ? 523 PHE A CD1 1 
ATOM   516 C CD2 . PHE A 1 66 ? -22.93380 6.38987  10.73603  1.000 24.39184 ? 523 PHE A CD2 1 
ATOM   517 C CE1 . PHE A 1 66 ? -23.32278 8.20009  12.79114  1.000 26.57245 ? 523 PHE A CE1 1 
ATOM   518 C CE2 . PHE A 1 66 ? -23.25251 7.70509  10.44697  1.000 23.52907 ? 523 PHE A CE2 1 
ATOM   519 C CZ  . PHE A 1 66 ? -23.45327 8.61180  11.47814  1.000 26.11923 ? 523 PHE A CZ  1 
ATOM   520 N N   . LYS A 1 67 ? -20.51456 2.34562  13.74596  1.000 24.56878 ? 524 LYS A N   1 
ATOM   521 C CA  . LYS A 1 67 ? -20.12273 0.98845  14.11962  1.000 25.17175 ? 524 LYS A CA  1 
ATOM   522 C C   . LYS A 1 67 ? -20.11074 0.81910  15.63230  1.000 26.58440 ? 524 LYS A C   1 
ATOM   523 O O   . LYS A 1 67 ? -20.56262 -0.20654 16.15144  1.000 24.64191 ? 524 LYS A O   1 
ATOM   524 C CB  . LYS A 1 67 ? -18.74532 0.64835  13.54136  1.000 25.80774 ? 524 LYS A CB  1 
ATOM   525 C CG  . LYS A 1 67 ? -18.73792 0.31853  12.05957  1.000 28.52538 ? 524 LYS A CG  1 
ATOM   526 C CD  . LYS A 1 67 ? -17.31816 0.03440  11.56924  1.000 30.12789 ? 524 LYS A CD  1 
ATOM   527 C CE  . LYS A 1 67 ? -16.87540 -1.36984 11.94533  1.000 31.62985 ? 524 LYS A CE  1 
ATOM   528 N NZ  . LYS A 1 67 ? -17.44569 -2.38179 11.01119  1.000 41.40726 ? 524 LYS A NZ  1 
ATOM   529 N N   . ALA A 1 68 ? -19.59582 1.81700  16.35780  1.000 25.98958 ? 525 ALA A N   1 
ATOM   530 C CA  . ALA A 1 68 ? -19.55672 1.74716  17.81605  1.000 24.04870 ? 525 ALA A CA  1 
ATOM   531 C C   . ALA A 1 68 ? -20.94518 1.71272  18.43224  1.000 26.89032 ? 525 ALA A C   1 
ATOM   532 O O   . ALA A 1 68 ? -21.08494 1.34696  19.60786  1.000 26.36133 ? 525 ALA A O   1 
ATOM   533 C CB  . ALA A 1 68 ? -18.77970 2.93804  18.37327  1.000 22.59997 ? 525 ALA A CB  1 
ATOM   534 N N   . ALA A 1 69 ? -21.97519 2.09465  17.67628  1.000 25.59371 ? 526 ALA A N   1 
ATOM   535 C CA  . ALA A 1 69 ? -23.33415 2.06803  18.20379  1.000 24.30682 ? 526 ALA A CA  1 
ATOM   536 C C   . ALA A 1 69 ? -23.96057 0.68612  18.11062  1.000 25.71463 ? 526 ALA A C   1 
ATOM   537 O O   . ALA A 1 69 ? -24.98877 0.43665  18.74913  1.000 26.88244 ? 526 ALA A O   1 
ATOM   538 C CB  . ALA A 1 69 ? -24.20694 3.08143  17.46224  1.000 24.69803 ? 526 ALA A CB  1 
ATOM   539 N N   . GLU A 1 70 ? -23.35512 -0.21645 17.34988  1.000 24.62498 ? 527 GLU A N   1 
ATOM   540 C CA  . GLU A 1 70 ? -23.90294 -1.54898 17.14985  1.000 25.96503 ? 527 GLU A CA  1 
ATOM   541 C C   . GLU A 1 70 ? -23.63203 -2.45756 18.33777  1.000 28.31279 ? 527 GLU A C   1 
ATOM   542 O O   . GLU A 1 70 ? -24.23305 -3.53027 18.41361  1.000 28.32645 ? 527 GLU A O   1 
ATOM   543 C CB  . GLU A 1 70 ? -23.33090 -2.16084 15.86678  1.000 26.23847 ? 527 GLU A CB  1 
ATOM   544 C CG  . GLU A 1 70 ? -23.59045 -1.30138 14.67340  1.000 23.18277 ? 527 GLU A CG  1 
ATOM   545 C CD  . GLU A 1 70 ? -23.38433 -2.03452 13.37195  1.000 30.83803 ? 527 GLU A CD  1 
ATOM   546 O OE1 . GLU A 1 70 ? -22.30403 -2.64660 13.19857  1.000 30.33093 ? 527 GLU A OE1 1 
ATOM   547 O OE2 . GLU A 1 70 ? -24.29739 -1.98471 12.52221  1.000 28.90448 ? 527 GLU A OE2 1 
ATOM   548 O OXT . GLU A 1 70 ? -22.82782 -2.14675 19.23189  1.000 25.81484 ? 527 GLU A OXT 1 
HETATM 549 O O   . HOH B 2 .  ? -33.81272 5.20360  0.17430   1.000 31.60802 ? 601 HOH A O   1 
HETATM 550 O O   . HOH B 2 .  ? -21.62187 22.61118 4.95287   1.000 27.26529 ? 602 HOH A O   1 
HETATM 551 O O   . HOH B 2 .  ? -25.69252 4.45894  -8.06452  1.000 25.41485 ? 603 HOH A O   1 
HETATM 552 O O   . HOH B 2 .  ? -11.55117 -1.73301 2.46772   1.000 22.85620 ? 604 HOH A O   1 
HETATM 553 O O   . HOH B 2 .  ? -26.01008 -0.17944 12.15497  1.000 26.06555 ? 605 HOH A O   1 
HETATM 554 O O   . HOH B 2 .  ? -18.66933 9.72072  -9.21091  1.000 31.23659 ? 606 HOH A O   1 
HETATM 555 O O   . HOH B 2 .  ? -22.74479 -0.21269 20.89662  1.000 29.32491 ? 607 HOH A O   1 
HETATM 556 O O   . HOH B 2 .  ? -33.94453 2.43967  4.44418   1.000 33.13002 ? 608 HOH A O   1 
HETATM 557 O O   . HOH B 2 .  ? -12.58608 9.45801  14.31877  1.000 29.63712 ? 609 HOH A O   1 
HETATM 558 O O   . HOH B 2 .  ? -15.08373 15.82251 -5.24663  1.000 21.13922 ? 610 HOH A O   1 
HETATM 559 O O   . HOH B 2 .  ? -31.19291 4.98795  -7.75539  1.000 33.12551 ? 611 HOH A O   1 
HETATM 560 O O   . HOH B 2 .  ? -8.44008  0.81415  0.50078   1.000 29.61998 ? 612 HOH A O   1 
HETATM 561 O O   . HOH B 2 .  ? -8.45923  -0.16601 3.04163   1.000 35.26084 ? 613 HOH A O   1 
HETATM 562 O O   . HOH B 2 .  ? -22.931   -3.135   -9.002    1.000 23.71798 ? 614 HOH A O   1 
HETATM 563 O O   . HOH B 2 .  ? -18.05685 13.01020 11.65417  1.000 29.89645 ? 615 HOH A O   1 
HETATM 564 O O   . HOH B 2 .  ? -15.91527 2.02852  15.76597  1.000 28.62609 ? 616 HOH A O   1 
HETATM 565 O O   . HOH B 2 .  ? -14.82927 21.75916 -2.79826  1.000 24.55106 ? 617 HOH A O   1 
HETATM 566 O O   . HOH B 2 .  ? -21.67793 5.40157  18.81195  1.000 27.31685 ? 618 HOH A O   1 
HETATM 567 O O   . HOH B 2 .  ? -5.98682  7.07945  4.43277   1.000 32.51874 ? 619 HOH A O   1 
HETATM 568 O O   . HOH B 2 .  ? -29.74609 0.92458  -1.54153  1.000 23.81159 ? 620 HOH A O   1 
HETATM 569 O O   . HOH B 2 .  ? -12.83797 15.02578 -3.97117  1.000 25.26655 ? 621 HOH A O   1 
HETATM 570 O O   . HOH B 2 .  ? -20.74074 -3.23890 11.03936  1.000 38.98908 ? 622 HOH A O   1 
HETATM 571 O O   . HOH B 2 .  ? -23.73940 19.95371 4.73878   1.000 29.63030 ? 623 HOH A O   1 
HETATM 572 O O   . HOH B 2 .  ? -19.04661 13.32993 -5.74976  1.000 23.20720 ? 624 HOH A O   1 
HETATM 573 O O   . HOH B 2 .  ? -24.55918 6.32966  -1.51816  1.000 23.44229 ? 625 HOH A O   1 
HETATM 574 O O   . HOH B 2 .  ? -22.80256 -3.99158 10.85062  1.000 32.86300 ? 626 HOH A O   1 
HETATM 575 O O   . HOH B 2 .  ? -7.36799  2.59768  5.89669   1.000 28.14618 ? 627 HOH A O   1 
HETATM 576 O O   . HOH B 2 .  ? -13.66069 19.42388 5.51836   1.000 25.86898 ? 628 HOH A O   1 
HETATM 577 O O   . HOH B 2 .  ? -25.73622 18.77674 -2.07353  1.000 35.93499 ? 629 HOH A O   1 
HETATM 578 O O   . HOH B 2 .  ? -14.69083 19.89904 3.19917   1.000 27.99565 ? 630 HOH A O   1 
HETATM 579 O O   . HOH B 2 .  ? -21.48230 -3.87513 7.15487   1.000 25.51209 ? 631 HOH A O   1 
HETATM 580 O O   . HOH B 2 .  ? -13.24642 -3.35341 4.53673   1.000 30.24053 ? 632 HOH A O   1 
HETATM 581 O O   . HOH B 2 .  ? -14.45907 12.07892 -5.73932  1.000 26.37497 ? 633 HOH A O   1 
HETATM 582 O O   . HOH B 2 .  ? -26.24996 15.05931 9.88479   1.000 34.53293 ? 634 HOH A O   1 
HETATM 583 O O   . HOH B 2 .  ? -27.70336 -1.26807 3.53920   1.000 25.78602 ? 635 HOH A O   1 
HETATM 584 O O   . HOH B 2 .  ? -28.77525 15.87403 2.96544   1.000 39.37084 ? 636 HOH A O   1 
HETATM 585 O O   . HOH B 2 .  ? -24.89642 2.66568  -10.09428 1.000 24.24811 ? 637 HOH A O   1 
HETATM 586 O O   . HOH B 2 .  ? -29.95377 9.38712  5.77117   1.000 25.17332 ? 638 HOH A O   1 
HETATM 587 O O   . HOH B 2 .  ? -18.18136 19.66401 -0.50930  1.000 25.00126 ? 639 HOH A O   1 
HETATM 588 O O   . HOH B 2 .  ? -15.09533 -0.12919 8.74818   1.000 30.87038 ? 640 HOH A O   1 
HETATM 589 O O   . HOH B 2 .  ? -7.58777  12.11264 -1.94902  1.000 33.00900 ? 641 HOH A O   1 
HETATM 590 O O   . HOH B 2 .  ? -27.57605 -4.01872 2.30958   1.000 35.80911 ? 642 HOH A O   1 
HETATM 591 O O   . HOH B 2 .  ? -23.18978 15.32632 -4.68923  1.000 34.96084 ? 643 HOH A O   1 
HETATM 592 O O   . HOH B 2 .  ? -16.54290 13.48545 -4.69210  1.000 23.11920 ? 644 HOH A O   1 
HETATM 593 O O   . HOH B 2 .  ? -9.13486  3.13113  8.27730   1.000 22.45096 ? 645 HOH A O   1 
HETATM 594 O O   . HOH B 2 .  ? -19.82532 -2.41260 19.10092  1.000 39.20123 ? 646 HOH A O   1 
HETATM 595 O O   . HOH B 2 .  ? -25.14847 1.68471  21.51946  1.000 30.19541 ? 647 HOH A O   1 
HETATM 596 O O   . HOH B 2 .  ? -31.54651 4.12525  -2.81532  1.000 27.44013 ? 648 HOH A O   1 
HETATM 597 O O   . HOH B 2 .  ? -12.53902 16.40273 -1.65708  1.000 25.12309 ? 649 HOH A O   1 
HETATM 598 O O   . HOH B 2 .  ? -16.611   15.205   14.737    1.000 33.71437 ? 650 HOH A O   1 
HETATM 599 O O   . HOH B 2 .  ? -26.26881 6.61677  -9.82321  1.000 32.38414 ? 651 HOH A O   1 
HETATM 600 O O   . HOH B 2 .  ? -35.30102 2.72439  2.34469   1.000 37.33457 ? 652 HOH A O   1 
HETATM 601 O O   . HOH B 2 .  ? -18.68757 12.82167 -8.52389  1.000 27.43099 ? 653 HOH A O   1 
HETATM 602 O O   . HOH B 2 .  ? -32.725   8.035    8.137     1.000 31.41294 ? 654 HOH A O   1 
HETATM 603 O O   . HOH B 2 .  ? -10.51851 1.09832  9.37505   1.000 34.68536 ? 655 HOH A O   1 
# 
