data_8Y2Y
# 
_entry.id   8Y2Y 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Y2Y         pdb_00008y2y 10.2210/pdb8y2y/pdb 
WWPDB D_1300044708 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-29 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Y2Y 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              22110700003@m.fudan.edu.cn 
_pdbx_contact_author.name_first         Anke 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3321-2002 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, A.K.' 1 ? 
'Li, J.X.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Emerg Microbes Infect' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2222-1751 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            13 
_citation.language                  ? 
_citation.page_first                2369193 
_citation.page_last                 2369193 
_citation.title                     'Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1080/22221751.2024.2369193 
_citation.pdbx_database_id_PubMed   38873898 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, A.'  1  ? 
primary 'Fang, N.'  2  ? 
primary 'Zhang, Z.' 3  ? 
primary 'Wen, Y.'   4  ? 
primary 'Shen, Y.'  5  ? 
primary 'Zhang, Y.' 6  ? 
primary 'Zhang, L.' 7  ? 
primary 'Zhao, G.'  8  ? 
primary 'Ding, J.'  9  ? 
primary 'Li, J.'    10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'mRNA-capping enzyme regulatory subunit OPG124' 33499.715 1  ? ? ? ? 
2 water   nat water                                           18.015    72 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Virus termination factor small subunit,mRNA-capping enzyme 33 kDa subunit,mRNA-capping enzyme D12 subunit,mRNA-capping enzyme small subunit
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDEIVKNIREGTHVLLPFYETLPELNLSLGKSPLPSLEYGANYFLQISRVNDLNRMPTDMLKLFTHDIMLPESDLDKVYE
ILKINSVKYYGRSTRADAVVADLSARNKLFKRERDAIKSNNHLTENNLYISDYKMLTFDVFRPLFDFVNEKYCIIKLPTL
FGRGVIDTMRIYCSLFKNVRLLKCVSDSWLKDSAIMVASDVYKKNLDLFMSHVKSVTKSSSWKDVNTVQFSILNDPVDTE
FINKFLEFSNRVYEALYYVHSLLYSSMTSDSKSIENKHQRRLVKLLL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDEIVKNIREGTHVLLPFYETLPELNLSLGKSPLPSLEYGANYFLQISRVNDLNRMPTDMLKLFTHDIMLPESDLDKVYE
ILKINSVKYYGRSTRADAVVADLSARNKLFKRERDAIKSNNHLTENNLYISDYKMLTFDVFRPLFDFVNEKYCIIKLPTL
FGRGVIDTMRIYCSLFKNVRLLKCVSDSWLKDSAIMVASDVYKKNLDLFMSHVKSVTKSSSWKDVNTVQFSILNDPVDTE
FINKFLEFSNRVYEALYYVHSLLYSSMTSDSKSIENKHQRRLVKLLL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   GLU n 
1 4   ILE n 
1 5   VAL n 
1 6   LYS n 
1 7   ASN n 
1 8   ILE n 
1 9   ARG n 
1 10  GLU n 
1 11  GLY n 
1 12  THR n 
1 13  HIS n 
1 14  VAL n 
1 15  LEU n 
1 16  LEU n 
1 17  PRO n 
1 18  PHE n 
1 19  TYR n 
1 20  GLU n 
1 21  THR n 
1 22  LEU n 
1 23  PRO n 
1 24  GLU n 
1 25  LEU n 
1 26  ASN n 
1 27  LEU n 
1 28  SER n 
1 29  LEU n 
1 30  GLY n 
1 31  LYS n 
1 32  SER n 
1 33  PRO n 
1 34  LEU n 
1 35  PRO n 
1 36  SER n 
1 37  LEU n 
1 38  GLU n 
1 39  TYR n 
1 40  GLY n 
1 41  ALA n 
1 42  ASN n 
1 43  TYR n 
1 44  PHE n 
1 45  LEU n 
1 46  GLN n 
1 47  ILE n 
1 48  SER n 
1 49  ARG n 
1 50  VAL n 
1 51  ASN n 
1 52  ASP n 
1 53  LEU n 
1 54  ASN n 
1 55  ARG n 
1 56  MET n 
1 57  PRO n 
1 58  THR n 
1 59  ASP n 
1 60  MET n 
1 61  LEU n 
1 62  LYS n 
1 63  LEU n 
1 64  PHE n 
1 65  THR n 
1 66  HIS n 
1 67  ASP n 
1 68  ILE n 
1 69  MET n 
1 70  LEU n 
1 71  PRO n 
1 72  GLU n 
1 73  SER n 
1 74  ASP n 
1 75  LEU n 
1 76  ASP n 
1 77  LYS n 
1 78  VAL n 
1 79  TYR n 
1 80  GLU n 
1 81  ILE n 
1 82  LEU n 
1 83  LYS n 
1 84  ILE n 
1 85  ASN n 
1 86  SER n 
1 87  VAL n 
1 88  LYS n 
1 89  TYR n 
1 90  TYR n 
1 91  GLY n 
1 92  ARG n 
1 93  SER n 
1 94  THR n 
1 95  ARG n 
1 96  ALA n 
1 97  ASP n 
1 98  ALA n 
1 99  VAL n 
1 100 VAL n 
1 101 ALA n 
1 102 ASP n 
1 103 LEU n 
1 104 SER n 
1 105 ALA n 
1 106 ARG n 
1 107 ASN n 
1 108 LYS n 
1 109 LEU n 
1 110 PHE n 
1 111 LYS n 
1 112 ARG n 
1 113 GLU n 
1 114 ARG n 
1 115 ASP n 
1 116 ALA n 
1 117 ILE n 
1 118 LYS n 
1 119 SER n 
1 120 ASN n 
1 121 ASN n 
1 122 HIS n 
1 123 LEU n 
1 124 THR n 
1 125 GLU n 
1 126 ASN n 
1 127 ASN n 
1 128 LEU n 
1 129 TYR n 
1 130 ILE n 
1 131 SER n 
1 132 ASP n 
1 133 TYR n 
1 134 LYS n 
1 135 MET n 
1 136 LEU n 
1 137 THR n 
1 138 PHE n 
1 139 ASP n 
1 140 VAL n 
1 141 PHE n 
1 142 ARG n 
1 143 PRO n 
1 144 LEU n 
1 145 PHE n 
1 146 ASP n 
1 147 PHE n 
1 148 VAL n 
1 149 ASN n 
1 150 GLU n 
1 151 LYS n 
1 152 TYR n 
1 153 CYS n 
1 154 ILE n 
1 155 ILE n 
1 156 LYS n 
1 157 LEU n 
1 158 PRO n 
1 159 THR n 
1 160 LEU n 
1 161 PHE n 
1 162 GLY n 
1 163 ARG n 
1 164 GLY n 
1 165 VAL n 
1 166 ILE n 
1 167 ASP n 
1 168 THR n 
1 169 MET n 
1 170 ARG n 
1 171 ILE n 
1 172 TYR n 
1 173 CYS n 
1 174 SER n 
1 175 LEU n 
1 176 PHE n 
1 177 LYS n 
1 178 ASN n 
1 179 VAL n 
1 180 ARG n 
1 181 LEU n 
1 182 LEU n 
1 183 LYS n 
1 184 CYS n 
1 185 VAL n 
1 186 SER n 
1 187 ASP n 
1 188 SER n 
1 189 TRP n 
1 190 LEU n 
1 191 LYS n 
1 192 ASP n 
1 193 SER n 
1 194 ALA n 
1 195 ILE n 
1 196 MET n 
1 197 VAL n 
1 198 ALA n 
1 199 SER n 
1 200 ASP n 
1 201 VAL n 
1 202 TYR n 
1 203 LYS n 
1 204 LYS n 
1 205 ASN n 
1 206 LEU n 
1 207 ASP n 
1 208 LEU n 
1 209 PHE n 
1 210 MET n 
1 211 SER n 
1 212 HIS n 
1 213 VAL n 
1 214 LYS n 
1 215 SER n 
1 216 VAL n 
1 217 THR n 
1 218 LYS n 
1 219 SER n 
1 220 SER n 
1 221 SER n 
1 222 TRP n 
1 223 LYS n 
1 224 ASP n 
1 225 VAL n 
1 226 ASN n 
1 227 THR n 
1 228 VAL n 
1 229 GLN n 
1 230 PHE n 
1 231 SER n 
1 232 ILE n 
1 233 LEU n 
1 234 ASN n 
1 235 ASP n 
1 236 PRO n 
1 237 VAL n 
1 238 ASP n 
1 239 THR n 
1 240 GLU n 
1 241 PHE n 
1 242 ILE n 
1 243 ASN n 
1 244 LYS n 
1 245 PHE n 
1 246 LEU n 
1 247 GLU n 
1 248 PHE n 
1 249 SER n 
1 250 ASN n 
1 251 ARG n 
1 252 VAL n 
1 253 TYR n 
1 254 GLU n 
1 255 ALA n 
1 256 LEU n 
1 257 TYR n 
1 258 TYR n 
1 259 VAL n 
1 260 HIS n 
1 261 SER n 
1 262 LEU n 
1 263 LEU n 
1 264 TYR n 
1 265 SER n 
1 266 SER n 
1 267 MET n 
1 268 THR n 
1 269 SER n 
1 270 ASP n 
1 271 SER n 
1 272 LYS n 
1 273 SER n 
1 274 ILE n 
1 275 GLU n 
1 276 ASN n 
1 277 LYS n 
1 278 HIS n 
1 279 GLN n 
1 280 ARG n 
1 281 ARG n 
1 282 LEU n 
1 283 VAL n 
1 284 LYS n 
1 285 LEU n 
1 286 LEU n 
1 287 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   287 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'OPG124, MPXVgp109' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Monkeypox virus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10244 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ASP 2   2   2   ASP ASP A . n 
A 1 3   GLU 3   3   3   GLU GLU A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   LYS 6   6   6   LYS LYS A . n 
A 1 7   ASN 7   7   7   ASN ASN A . n 
A 1 8   ILE 8   8   8   ILE ILE A . n 
A 1 9   ARG 9   9   9   ARG ARG A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  HIS 13  13  13  HIS HIS A . n 
A 1 14  VAL 14  14  14  VAL VAL A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  PRO 17  17  17  PRO PRO A . n 
A 1 18  PHE 18  18  18  PHE PHE A . n 
A 1 19  TYR 19  19  19  TYR TYR A . n 
A 1 20  GLU 20  20  20  GLU GLU A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  PRO 23  23  23  PRO PRO A . n 
A 1 24  GLU 24  24  24  GLU GLU A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  LEU 29  29  29  LEU LEU A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  LYS 31  31  31  LYS LYS A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  PRO 35  35  35  PRO PRO A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  GLU 38  38  38  GLU GLU A . n 
A 1 39  TYR 39  39  39  TYR TYR A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  ASN 42  42  42  ASN ASN A . n 
A 1 43  TYR 43  43  43  TYR TYR A . n 
A 1 44  PHE 44  44  44  PHE PHE A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  ILE 47  47  47  ILE ILE A . n 
A 1 48  SER 48  48  48  SER SER A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  VAL 50  50  50  VAL VAL A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  ARG 55  55  55  ARG ARG A . n 
A 1 56  MET 56  56  56  MET MET A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  THR 58  58  58  THR THR A . n 
A 1 59  ASP 59  59  59  ASP ASP A . n 
A 1 60  MET 60  60  60  MET MET A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  THR 65  65  65  THR THR A . n 
A 1 66  HIS 66  66  66  HIS HIS A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  ILE 68  68  68  ILE ILE A . n 
A 1 69  MET 69  69  69  MET MET A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  GLU 72  72  72  GLU GLU A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ASP 76  76  76  ASP ASP A . n 
A 1 77  LYS 77  77  77  LYS LYS A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  GLU 80  80  80  GLU GLU A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  ASN 85  85  85  ASN ASN A . n 
A 1 86  SER 86  86  ?   ?   ?   A . n 
A 1 87  VAL 87  87  ?   ?   ?   A . n 
A 1 88  LYS 88  88  ?   ?   ?   A . n 
A 1 89  TYR 89  89  ?   ?   ?   A . n 
A 1 90  TYR 90  90  ?   ?   ?   A . n 
A 1 91  GLY 91  91  ?   ?   ?   A . n 
A 1 92  ARG 92  92  ?   ?   ?   A . n 
A 1 93  SER 93  93  ?   ?   ?   A . n 
A 1 94  THR 94  94  ?   ?   ?   A . n 
A 1 95  ARG 95  95  ?   ?   ?   A . n 
A 1 96  ALA 96  96  ?   ?   ?   A . n 
A 1 97  ASP 97  97  97  ASP ASP A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 VAL 100 100 100 VAL VAL A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 SER 104 104 104 SER SER A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 ARG 106 106 106 ARG ARG A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 LYS 108 108 108 LYS LYS A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 PHE 110 110 110 PHE PHE A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 ARG 112 112 112 ARG ARG A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 ASP 115 115 115 ASP ASP A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 ILE 117 117 117 ILE ILE A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 SER 119 119 119 SER SER A . n 
A 1 120 ASN 120 120 120 ASN ASN A . n 
A 1 121 ASN 121 121 121 ASN ASN A . n 
A 1 122 HIS 122 122 122 HIS HIS A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 ASN 126 126 126 ASN ASN A . n 
A 1 127 ASN 127 127 127 ASN ASN A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 TYR 129 129 129 TYR TYR A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 ASP 132 132 132 ASP ASP A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 LYS 134 134 134 LYS LYS A . n 
A 1 135 MET 135 135 135 MET MET A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 THR 137 137 137 THR THR A . n 
A 1 138 PHE 138 138 138 PHE PHE A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 VAL 140 140 140 VAL VAL A . n 
A 1 141 PHE 141 141 141 PHE PHE A . n 
A 1 142 ARG 142 142 142 ARG ARG A . n 
A 1 143 PRO 143 143 143 PRO PRO A . n 
A 1 144 LEU 144 144 144 LEU LEU A . n 
A 1 145 PHE 145 145 145 PHE PHE A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 ASN 149 149 149 ASN ASN A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 LYS 151 151 151 LYS LYS A . n 
A 1 152 TYR 152 152 152 TYR TYR A . n 
A 1 153 CYS 153 153 153 CYS CYS A . n 
A 1 154 ILE 154 154 154 ILE ILE A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 LYS 156 156 156 LYS LYS A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 PRO 158 158 158 PRO PRO A . n 
A 1 159 THR 159 159 159 THR THR A . n 
A 1 160 LEU 160 160 160 LEU LEU A . n 
A 1 161 PHE 161 161 161 PHE PHE A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ARG 163 163 163 ARG ARG A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 THR 168 168 168 THR THR A . n 
A 1 169 MET 169 169 169 MET MET A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 TYR 172 172 172 TYR TYR A . n 
A 1 173 CYS 173 173 173 CYS CYS A . n 
A 1 174 SER 174 174 174 SER SER A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 PHE 176 176 176 PHE PHE A . n 
A 1 177 LYS 177 177 177 LYS LYS A . n 
A 1 178 ASN 178 178 178 ASN ASN A . n 
A 1 179 VAL 179 179 179 VAL VAL A . n 
A 1 180 ARG 180 180 180 ARG ARG A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 LYS 183 183 183 LYS LYS A . n 
A 1 184 CYS 184 184 184 CYS CYS A . n 
A 1 185 VAL 185 185 185 VAL VAL A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 TRP 189 189 189 TRP TRP A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ASP 192 192 192 ASP ASP A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 MET 196 196 196 MET MET A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 ASP 200 200 200 ASP ASP A . n 
A 1 201 VAL 201 201 201 VAL VAL A . n 
A 1 202 TYR 202 202 202 TYR TYR A . n 
A 1 203 LYS 203 203 203 LYS LYS A . n 
A 1 204 LYS 204 204 204 LYS LYS A . n 
A 1 205 ASN 205 205 205 ASN ASN A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 ASP 207 207 207 ASP ASP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 PHE 209 209 209 PHE PHE A . n 
A 1 210 MET 210 210 210 MET MET A . n 
A 1 211 SER 211 211 211 SER SER A . n 
A 1 212 HIS 212 212 212 HIS HIS A . n 
A 1 213 VAL 213 213 213 VAL VAL A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 SER 215 215 215 SER SER A . n 
A 1 216 VAL 216 216 216 VAL VAL A . n 
A 1 217 THR 217 217 217 THR THR A . n 
A 1 218 LYS 218 218 218 LYS LYS A . n 
A 1 219 SER 219 219 219 SER SER A . n 
A 1 220 SER 220 220 220 SER SER A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 TRP 222 222 222 TRP TRP A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 ASP 224 224 224 ASP ASP A . n 
A 1 225 VAL 225 225 225 VAL VAL A . n 
A 1 226 ASN 226 226 226 ASN ASN A . n 
A 1 227 THR 227 227 227 THR THR A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 GLN 229 229 229 GLN GLN A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 ILE 232 232 232 ILE ILE A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 ASN 234 234 234 ASN ASN A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 PRO 236 236 236 PRO PRO A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PHE 241 241 241 PHE PHE A . n 
A 1 242 ILE 242 242 242 ILE ILE A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 LYS 244 244 244 LYS LYS A . n 
A 1 245 PHE 245 245 245 PHE PHE A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 GLU 247 247 247 GLU GLU A . n 
A 1 248 PHE 248 248 248 PHE PHE A . n 
A 1 249 SER 249 249 249 SER SER A . n 
A 1 250 ASN 250 250 250 ASN ASN A . n 
A 1 251 ARG 251 251 251 ARG ARG A . n 
A 1 252 VAL 252 252 252 VAL VAL A . n 
A 1 253 TYR 253 253 253 TYR TYR A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 TYR 257 257 257 TYR TYR A . n 
A 1 258 TYR 258 258 258 TYR TYR A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 HIS 260 260 260 HIS HIS A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 LEU 263 263 263 LEU LEU A . n 
A 1 264 TYR 264 264 264 TYR TYR A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 SER 266 266 266 SER SER A . n 
A 1 267 MET 267 267 267 MET MET A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 SER 269 269 269 SER SER A . n 
A 1 270 ASP 270 270 270 ASP ASP A . n 
A 1 271 SER 271 271 271 SER SER A . n 
A 1 272 LYS 272 272 272 LYS LYS A . n 
A 1 273 SER 273 273 273 SER SER A . n 
A 1 274 ILE 274 274 274 ILE ILE A . n 
A 1 275 GLU 275 275 275 GLU GLU A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 LYS 277 277 277 LYS LYS A . n 
A 1 278 HIS 278 278 278 HIS HIS A . n 
A 1 279 GLN 279 279 279 GLN GLN A . n 
A 1 280 ARG 280 280 280 ARG ARG A . n 
A 1 281 ARG 281 281 281 ARG ARG A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 VAL 283 283 283 VAL VAL A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1  301 29 HOH HOH A . 
B 2 HOH 2  302 8  HOH HOH A . 
B 2 HOH 3  303 27 HOH HOH A . 
B 2 HOH 4  304 41 HOH HOH A . 
B 2 HOH 5  305 60 HOH HOH A . 
B 2 HOH 6  306 62 HOH HOH A . 
B 2 HOH 7  307 13 HOH HOH A . 
B 2 HOH 8  308 43 HOH HOH A . 
B 2 HOH 9  309 19 HOH HOH A . 
B 2 HOH 10 310 36 HOH HOH A . 
B 2 HOH 11 311 16 HOH HOH A . 
B 2 HOH 12 312 35 HOH HOH A . 
B 2 HOH 13 313 20 HOH HOH A . 
B 2 HOH 14 314 26 HOH HOH A . 
B 2 HOH 15 315 22 HOH HOH A . 
B 2 HOH 16 316 71 HOH HOH A . 
B 2 HOH 17 317 42 HOH HOH A . 
B 2 HOH 18 318 24 HOH HOH A . 
B 2 HOH 19 319 44 HOH HOH A . 
B 2 HOH 20 320 18 HOH HOH A . 
B 2 HOH 21 321 34 HOH HOH A . 
B 2 HOH 22 322 2  HOH HOH A . 
B 2 HOH 23 323 54 HOH HOH A . 
B 2 HOH 24 324 5  HOH HOH A . 
B 2 HOH 25 325 11 HOH HOH A . 
B 2 HOH 26 326 4  HOH HOH A . 
B 2 HOH 27 327 14 HOH HOH A . 
B 2 HOH 28 328 15 HOH HOH A . 
B 2 HOH 29 329 30 HOH HOH A . 
B 2 HOH 30 330 61 HOH HOH A . 
B 2 HOH 31 331 49 HOH HOH A . 
B 2 HOH 32 332 58 HOH HOH A . 
B 2 HOH 33 333 6  HOH HOH A . 
B 2 HOH 34 334 10 HOH HOH A . 
B 2 HOH 35 335 63 HOH HOH A . 
B 2 HOH 36 336 1  HOH HOH A . 
B 2 HOH 37 337 21 HOH HOH A . 
B 2 HOH 38 338 31 HOH HOH A . 
B 2 HOH 39 339 33 HOH HOH A . 
B 2 HOH 40 340 3  HOH HOH A . 
B 2 HOH 41 341 64 HOH HOH A . 
B 2 HOH 42 342 39 HOH HOH A . 
B 2 HOH 43 343 48 HOH HOH A . 
B 2 HOH 44 344 51 HOH HOH A . 
B 2 HOH 45 345 67 HOH HOH A . 
B 2 HOH 46 346 55 HOH HOH A . 
B 2 HOH 47 347 12 HOH HOH A . 
B 2 HOH 48 348 28 HOH HOH A . 
B 2 HOH 49 349 59 HOH HOH A . 
B 2 HOH 50 350 56 HOH HOH A . 
B 2 HOH 51 351 17 HOH HOH A . 
B 2 HOH 52 352 7  HOH HOH A . 
B 2 HOH 53 353 52 HOH HOH A . 
B 2 HOH 54 354 40 HOH HOH A . 
B 2 HOH 55 355 32 HOH HOH A . 
B 2 HOH 56 356 46 HOH HOH A . 
B 2 HOH 57 357 38 HOH HOH A . 
B 2 HOH 58 358 68 HOH HOH A . 
B 2 HOH 59 359 72 HOH HOH A . 
B 2 HOH 60 360 9  HOH HOH A . 
B 2 HOH 61 361 25 HOH HOH A . 
B 2 HOH 62 362 53 HOH HOH A . 
B 2 HOH 63 363 69 HOH HOH A . 
B 2 HOH 64 364 47 HOH HOH A . 
B 2 HOH 65 365 70 HOH HOH A . 
B 2 HOH 66 366 45 HOH HOH A . 
B 2 HOH 67 367 57 HOH HOH A . 
B 2 HOH 68 368 37 HOH HOH A . 
B 2 HOH 69 369 50 HOH HOH A . 
B 2 HOH 70 370 66 HOH HOH A . 
B 2 HOH 71 371 65 HOH HOH A . 
B 2 HOH 72 372 23 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 83  ? CG  ? A LYS 83  CG  
2  1 Y 1 A LYS 83  ? CD  ? A LYS 83  CD  
3  1 Y 1 A LYS 83  ? CE  ? A LYS 83  CE  
4  1 Y 1 A LYS 83  ? NZ  ? A LYS 83  NZ  
5  1 Y 1 A VAL 148 ? CG1 ? A VAL 148 CG1 
6  1 Y 1 A VAL 148 ? CG2 ? A VAL 148 CG2 
7  1 Y 1 A GLU 275 ? CG  ? A GLU 275 CG  
8  1 Y 1 A GLU 275 ? CD  ? A GLU 275 CD  
9  1 Y 1 A GLU 275 ? OE1 ? A GLU 275 OE1 
10 1 Y 1 A GLU 275 ? OE2 ? A GLU 275 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.18.2_3874: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Y2Y 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     77.242 
_cell.length_a_esd                 ? 
_cell.length_b                     77.242 
_cell.length_b_esd                 ? 
_cell.length_c                     96.944 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Y2Y 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Y2Y 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.49 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.64 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2.0M Ammonium sulfate, 0.1M CAPS/Sodium hydroxide pH 10.5, 0.2M Lithium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.987 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.987 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8Y2Y 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.14 
_reflns.d_resolution_low                               66.89 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18965 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          2.217 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.082 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.2 
_reflns_shell.d_res_low                                     2.279 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             18965 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.999 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Y2Y 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             66.89 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17447 
_refine.ls_number_reflns_R_free                  871 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.97 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2059 
_refine.ls_R_factor_R_free                       0.2715 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2024 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.42 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 32.62 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.28 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        66.89 
_refine_hist.number_atoms_solvent             72 
_refine_hist.number_atoms_total               2327 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2255 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.015  ? 2298 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.584  ? 3108 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 12.496 ? 302  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.062  ? 358  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.012  ? 390  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.34  . . 146 2707 100.00 . . . . 0.2538 . . . . . . . . . . . 0.3120 
'X-RAY DIFFRACTION' 2.34 2.52  . . 121 2730 100.00 . . . . 0.2062 . . . . . . . . . . . 0.3065 
'X-RAY DIFFRACTION' 2.52 2.77  . . 147 2722 100.00 . . . . 0.2614 . . . . . . . . . . . 0.2859 
'X-RAY DIFFRACTION' 2.77 3.17  . . 146 2757 100.00 . . . . 0.2254 . . . . . . . . . . . 0.3146 
'X-RAY DIFFRACTION' 3.17 3.99  . . 154 2762 100.00 . . . . 0.2012 . . . . . . . . . . . 0.2860 
'X-RAY DIFFRACTION' 4.00 66.89 . . 157 2898 100.00 . . . . 0.1745 . . . . . . . . . . . 0.2334 
# 
_struct.entry_id                     8Y2Y 
_struct.title                        'MPXV mRNA capping enzyme small subunit' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Y2Y 
_struct_keywords.text            'small subunit, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MCES_MONPV 
_struct_ref.pdbx_db_accession          A0A7H0DN96 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDEIVKNIREGTHVLLPFYETLPELNLSLGKSPLPSLEYGANYFLQISRVNDLNRMPTDMLKLFTHDIMLPESDLDKVYE
ILKINSVKYYGRSTRADAVVADLSARNKLFKRERDAIKSNNHLTENNLYISDYKMLTFDVFRPLFDFVNEKYCIIKLPTL
FGRGVIDTMRIYCSLFKNVRLLKCVSDSWLKDSAIMVASDVYKKNLDLFMSHVKSVTKSSSWKDVNTVQFSILNDPVDTE
FINKFLEFSNRVYEALYYVHSLLYSSMTSDSKSIENKHQRRLVKLLL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Y2Y 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 287 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A7H0DN96 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  287 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       287 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 MET A 1   ? GLY A 11  ? MET A 1   GLY A 11  1 ? 11 
HELX_P HELX_P2  AA2 ASN A 42  ? ILE A 47  ? ASN A 42  ILE A 47  1 ? 6  
HELX_P HELX_P3  AA3 ILE A 47  ? ARG A 55  ? ILE A 47  ARG A 55  1 ? 9  
HELX_P HELX_P4  AA4 PRO A 57  ? HIS A 66  ? PRO A 57  HIS A 66  1 ? 10 
HELX_P HELX_P5  AA5 SER A 73  ? LEU A 82  ? SER A 73  LEU A 82  1 ? 10 
HELX_P HELX_P6  AA6 ASP A 132 ? LEU A 136 ? ASP A 132 LEU A 136 5 ? 5  
HELX_P HELX_P7  AA7 THR A 137 ? VAL A 140 ? THR A 137 VAL A 140 5 ? 4  
HELX_P HELX_P8  AA8 PHE A 141 ? ASP A 146 ? PHE A 141 ASP A 146 1 ? 6  
HELX_P HELX_P9  AA9 GLY A 162 ? LEU A 175 ? GLY A 162 LEU A 175 1 ? 14 
HELX_P HELX_P10 AB1 TYR A 202 ? LYS A 218 ? TYR A 202 LYS A 218 1 ? 17 
HELX_P HELX_P11 AB2 LYS A 223 ? THR A 227 ? LYS A 223 THR A 227 5 ? 5  
HELX_P HELX_P12 AB3 ASP A 238 ? THR A 268 ? ASP A 238 THR A 268 1 ? 31 
HELX_P HELX_P13 AB4 ASN A 276 ? LEU A 287 ? ASN A 276 LEU A 287 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 12  ? LEU A 16  ? THR A 12  LEU A 16  
AA1 2 PHE A 176 ? LYS A 183 ? PHE A 176 LYS A 183 
AA1 3 ALA A 194 ? VAL A 201 ? ALA A 194 VAL A 201 
AA1 4 TYR A 152 ? LEU A 157 ? TYR A 152 LEU A 157 
AA1 5 ALA A 98  ? ASP A 102 ? ALA A 98  ASP A 102 
AA2 1 LEU A 25  ? LEU A 29  ? LEU A 25  LEU A 29  
AA2 2 PHE A 230 ? LEU A 233 ? PHE A 230 LEU A 233 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 16  ? N LEU A 16  O VAL A 179 ? O VAL A 179 
AA1 2 3 N LEU A 182 ? N LEU A 182 O ILE A 195 ? O ILE A 195 
AA1 3 4 O MET A 196 ? O MET A 196 N ILE A 155 ? N ILE A 155 
AA1 4 5 O TYR A 152 ? O TYR A 152 N VAL A 99  ? N VAL A 99  
AA2 1 2 N SER A 28  ? N SER A 28  O SER A 231 ? O SER A 231 
# 
_pdbx_entry_details.entry_id                   8Y2Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 H A LEU 27  ? ? HE2 A HIS 212 ? ? 1.27 
2 1 O A ASP 238 ? ? H   A PHE 241 ? ? 1.57 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CB A GLU 72  ? ? CG  A GLU 72  ? ? 1.631 1.517 0.114  0.019 N 
2 1 CD A GLU 72  ? ? OE2 A GLU 72  ? ? 1.163 1.252 -0.089 0.011 N 
3 1 CG A ARG 112 ? ? CD  A ARG 112 ? ? 1.679 1.515 0.164  0.025 N 
4 1 CG A GLU 125 ? ? CD  A GLU 125 ? ? 1.606 1.515 0.091  0.015 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA A LYS 118 ? ? CB A LYS 118 ? ? CG  A LYS 118 ? ? 99.72  113.40 -13.68 2.20 N 
2 1 CB A ASP 187 ? ? CG A ASP 187 ? ? OD1 A ASP 187 ? ? 124.46 118.30 6.16   0.90 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 26  ? ? -165.24 59.80  
2  1 LYS A 83  ? ? 29.24   64.63  
3  1 ALA A 105 ? ? -106.51 73.78  
4  1 ASP A 146 ? ? -81.81  32.56  
5  1 VAL A 148 ? ? -145.85 -73.25 
6  1 ASN A 149 ? ? -141.15 27.92  
7  1 ASP A 192 ? ? -92.75  44.83  
8  1 ASP A 200 ? ? 68.44   75.30  
9  1 ILE A 232 ? ? -132.49 -32.34 
10 1 ASN A 234 ? ? -103.00 -66.82 
11 1 PRO A 236 ? ? -43.61  164.15 
12 1 THR A 239 ? ? -37.69  -39.83 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    GLU 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     72 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.070 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     344 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   B 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 86 ? A SER 86 
2  1 Y 1 A VAL 87 ? A VAL 87 
3  1 Y 1 A LYS 88 ? A LYS 88 
4  1 Y 1 A TYR 89 ? A TYR 89 
5  1 Y 1 A TYR 90 ? A TYR 90 
6  1 Y 1 A GLY 91 ? A GLY 91 
7  1 Y 1 A ARG 92 ? A ARG 92 
8  1 Y 1 A SER 93 ? A SER 93 
9  1 Y 1 A THR 94 ? A THR 94 
10 1 Y 1 A ARG 95 ? A ARG 95 
11 1 Y 1 A ALA 96 ? A ALA 96 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, China)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8Y2Y 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012946 
_atom_sites.fract_transf_matrix[1][2]   0.007475 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014949 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010315 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . MET A 1 1   ? -39.718 41.673 17.216  1.00 58.92  ? 1   MET A N    1 
ATOM   2    C CA   . MET A 1 1   ? -39.916 40.487 18.084  1.00 55.45  ? 1   MET A CA   1 
ATOM   3    C C    . MET A 1 1   ? -38.601 39.718 18.184  1.00 62.05  ? 1   MET A C    1 
ATOM   4    O O    . MET A 1 1   ? -37.794 39.787 17.253  1.00 58.30  ? 1   MET A O    1 
ATOM   5    C CB   . MET A 1 1   ? -41.023 39.573 17.575  1.00 30.00  ? 1   MET A CB   1 
ATOM   6    C CG   . MET A 1 1   ? -41.064 38.214 18.178  1.00 30.00  ? 1   MET A CG   1 
ATOM   7    S SD   . MET A 1 1   ? -42.484 38.057 19.264  1.00 30.00  ? 1   MET A SD   1 
ATOM   8    C CE   . MET A 1 1   ? -43.562 37.085 18.217  1.00 30.00  ? 1   MET A CE   1 
ATOM   9    N N    . ASP A 1 2   ? -38.401 39.034 19.294  1.00 61.39  ? 2   ASP A N    1 
ATOM   10   C CA   . ASP A 1 2   ? -37.151 38.314 19.566  1.00 62.86  ? 2   ASP A CA   1 
ATOM   11   C C    . ASP A 1 2   ? -37.312 36.908 19.037  1.00 52.67  ? 2   ASP A C    1 
ATOM   12   O O    . ASP A 1 2   ? -36.325 36.274 18.947  1.00 55.88  ? 2   ASP A O    1 
ATOM   13   C CB   . ASP A 1 2   ? -36.830 38.376 21.057  1.00 70.08  ? 2   ASP A CB   1 
ATOM   14   C CG   . ASP A 1 2   ? -36.449 39.764 21.541  1.00 76.80  ? 2   ASP A CG   1 
ATOM   15   O OD1  . ASP A 1 2   ? -36.027 40.580 20.699  1.00 76.90  ? 2   ASP A OD1  1 
ATOM   16   O OD2  . ASP A 1 2   ? -36.576 40.018 22.752  1.00 76.63  ? 2   ASP A OD2  1 
ATOM   17   H H    . ASP A 1 2   ? -39.015 38.980 19.963  1.00 73.72  ? 2   ASP A H    1 
ATOM   18   H HA   . ASP A 1 2   ? -36.423 38.755 19.070  1.00 75.49  ? 2   ASP A HA   1 
ATOM   19   H HB2  . ASP A 1 2   ? -37.612 38.074 21.562  1.00 84.15  ? 2   ASP A HB2  1 
ATOM   20   H HB3  . ASP A 1 2   ? -36.088 37.767 21.249  1.00 84.15  ? 2   ASP A HB3  1 
ATOM   21   N N    . GLU A 1 3   ? -38.524 36.441 18.828  1.00 50.44  ? 3   GLU A N    1 
ATOM   22   C CA   . GLU A 1 3   ? -38.747 35.136 18.177  1.00 52.93  ? 3   GLU A CA   1 
ATOM   23   C C    . GLU A 1 3   ? -38.438 35.262 16.687  1.00 53.31  ? 3   GLU A C    1 
ATOM   24   O O    . GLU A 1 3   ? -37.973 34.313 16.176  1.00 48.65  ? 3   GLU A O    1 
ATOM   25   C CB   . GLU A 1 3   ? -40.159 34.620 18.361  1.00 51.33  ? 3   GLU A CB   1 
ATOM   26   C CG   . GLU A 1 3   ? -40.196 33.240 18.985  1.00 61.70  ? 3   GLU A CG   1 
ATOM   27   C CD   . GLU A 1 3   ? -40.759 32.140 18.106  1.00 70.96  ? 3   GLU A CD   1 
ATOM   28   O OE1  . GLU A 1 3   ? -41.845 32.343 17.542  1.00 73.41  ? 3   GLU A OE1  1 
ATOM   29   O OE2  . GLU A 1 3   ? -40.122 31.074 18.018  1.00 73.88  ? 3   GLU A OE2  1 
ATOM   30   H H    . GLU A 1 3   ? -39.258 36.815 19.180  1.00 60.58  ? 3   GLU A H    1 
ATOM   31   H HA   . GLU A 1 3   ? -38.122 34.486 18.567  1.00 63.57  ? 3   GLU A HA   1 
ATOM   32   H HB2  . GLU A 1 3   ? -40.653 35.244 18.931  1.00 61.65  ? 3   GLU A HB2  1 
ATOM   33   H HB3  . GLU A 1 3   ? -40.598 34.594 17.487  1.00 61.65  ? 3   GLU A HB3  1 
ATOM   34   H HG2  . GLU A 1 3   ? -39.287 32.985 19.246  1.00 74.09  ? 3   GLU A HG2  1 
ATOM   35   H HG3  . GLU A 1 3   ? -40.733 33.281 19.803  1.00 74.09  ? 3   GLU A HG3  1 
ATOM   36   N N    . ILE A 1 4   ? -38.759 36.368 16.024  1.00 52.73  ? 4   ILE A N    1 
ATOM   37   C CA   . ILE A 1 4   ? -38.389 36.598 14.629  1.00 46.88  ? 4   ILE A CA   1 
ATOM   38   C C    . ILE A 1 4   ? -36.889 36.547 14.460  1.00 49.09  ? 4   ILE A C    1 
ATOM   39   O O    . ILE A 1 4   ? -36.365 35.870 13.565  1.00 44.79  ? 4   ILE A O    1 
ATOM   40   C CB   . ILE A 1 4   ? -38.929 37.947 14.144  1.00 45.00  ? 4   ILE A CB   1 
ATOM   41   C CG1  . ILE A 1 4   ? -40.432 37.841 13.919  1.00 47.72  ? 4   ILE A CG1  1 
ATOM   42   C CG2  . ILE A 1 4   ? -38.159 38.362 12.869  1.00 49.66  ? 4   ILE A CG2  1 
ATOM   43   C CD1  . ILE A 1 4   ? -41.086 39.164 13.725  1.00 47.74  ? 4   ILE A CD1  1 
ATOM   44   H H    . ILE A 1 4   ? -39.223 37.003 16.372  1.00 63.33  ? 4   ILE A H    1 
ATOM   45   H HA   . ILE A 1 4   ? -38.786 35.891 14.097  1.00 56.30  ? 4   ILE A HA   1 
ATOM   46   H HB   . ILE A 1 4   ? -38.790 38.636 14.812  1.00 54.05  ? 4   ILE A HB   1 
ATOM   47   H HG12 . ILE A 1 4   ? -40.595 37.308 13.125  1.00 57.31  ? 4   ILE A HG12 1 
ATOM   48   H HG13 . ILE A 1 4   ? -40.837 37.418 14.692  1.00 57.31  ? 4   ILE A HG13 1 
ATOM   49   H HG21 . ILE A 1 4   ? -38.652 39.064 12.417  1.00 59.64  ? 4   ILE A HG21 1 
ATOM   50   H HG22 . ILE A 1 4   ? -37.280 38.685 13.121  1.00 59.64  ? 4   ILE A HG22 1 
ATOM   51   H HG23 . ILE A 1 4   ? -38.074 37.591 12.287  1.00 59.64  ? 4   ILE A HG23 1 
ATOM   52   H HD11 . ILE A 1 4   ? -40.830 39.752 14.452  1.00 57.34  ? 4   ILE A HD11 1 
ATOM   53   H HD12 . ILE A 1 4   ? -42.048 39.042 13.721  1.00 57.34  ? 4   ILE A HD12 1 
ATOM   54   H HD13 . ILE A 1 4   ? -40.797 39.538 12.878  1.00 57.34  ? 4   ILE A HD13 1 
ATOM   55   N N    . VAL A 1 5   ? -36.167 37.310 15.284  1.00 49.36  ? 5   VAL A N    1 
ATOM   56   C CA   . VAL A 1 5   ? -34.722 37.410 15.098  1.00 47.61  ? 5   VAL A CA   1 
ATOM   57   C C    . VAL A 1 5   ? -34.055 36.113 15.498  1.00 47.78  ? 5   VAL A C    1 
ATOM   58   O O    . VAL A 1 5   ? -33.066 35.692 14.878  1.00 50.00  ? 5   VAL A O    1 
ATOM   59   C CB   . VAL A 1 5   ? -34.159 38.597 15.899  1.00 54.93  ? 5   VAL A CB   1 
ATOM   60   C CG1  . VAL A 1 5   ? -32.617 38.583 15.839  1.00 60.85  ? 5   VAL A CG1  1 
ATOM   61   C CG2  . VAL A 1 5   ? -34.714 39.916 15.366  1.00 58.10  ? 5   VAL A CG2  1 
ATOM   62   H H    . VAL A 1 5   ? -36.482 37.767 15.941  1.00 59.28  ? 5   VAL A H    1 
ATOM   63   H HA   . VAL A 1 5   ? -34.543 37.571 14.158  1.00 57.19  ? 5   VAL A HA   1 
ATOM   64   H HB   . VAL A 1 5   ? -34.430 38.517 16.827  1.00 65.97  ? 5   VAL A HB   1 
ATOM   65   H HG11 . VAL A 1 5   ? -32.293 39.498 15.847  1.00 73.07  ? 5   VAL A HG11 1 
ATOM   66   H HG12 . VAL A 1 5   ? -32.337 38.141 15.022  1.00 73.07  ? 5   VAL A HG12 1 
ATOM   67   H HG13 . VAL A 1 5   ? -32.275 38.104 16.609  1.00 73.07  ? 5   VAL A HG13 1 
ATOM   68   H HG21 . VAL A 1 5   ? -34.802 39.856 14.402  1.00 69.77  ? 5   VAL A HG21 1 
ATOM   69   H HG22 . VAL A 1 5   ? -35.582 40.079 15.768  1.00 69.77  ? 5   VAL A HG22 1 
ATOM   70   H HG23 . VAL A 1 5   ? -34.103 40.633 15.599  1.00 69.77  ? 5   VAL A HG23 1 
ATOM   71   N N    . LYS A 1 6   ? -34.566 35.475 16.567  1.00 49.45  ? 6   LYS A N    1 
ATOM   72   C CA   . LYS A 1 6   ? -34.089 34.145 16.942  1.00 48.32  ? 6   LYS A CA   1 
ATOM   73   C C    . LYS A 1 6   ? -34.264 33.164 15.799  1.00 46.89  ? 6   LYS A C    1 
ATOM   74   O O    . LYS A 1 6   ? -33.353 32.377 15.497  1.00 46.51  ? 6   LYS A O    1 
ATOM   75   C CB   . LYS A 1 6   ? -34.843 33.658 18.180  1.00 58.83  ? 6   LYS A CB   1 
ATOM   76   C CG   . LYS A 1 6   ? -34.234 32.475 18.931  1.00 60.42  ? 6   LYS A CG   1 
ATOM   77   C CD   . LYS A 1 6   ? -35.061 32.129 20.216  1.00 63.88  ? 6   LYS A CD   1 
ATOM   78   C CE   . LYS A 1 6   ? -36.343 31.355 19.859  1.00 63.20  ? 6   LYS A CE   1 
ATOM   79   N NZ   . LYS A 1 6   ? -37.436 31.465 20.872  1.00 70.98  ? 6   LYS A NZ   1 
ATOM   80   H H    . LYS A 1 6   ? -35.179 35.791 17.080  1.00 59.39  ? 6   LYS A H    1 
ATOM   81   H HA   . LYS A 1 6   ? -33.144 34.194 17.158  1.00 58.04  ? 6   LYS A HA   1 
ATOM   82   H HB2  . LYS A 1 6   ? -34.897 34.395 18.808  1.00 70.65  ? 6   LYS A HB2  1 
ATOM   83   H HB3  . LYS A 1 6   ? -35.733 33.391 17.904  1.00 70.65  ? 6   LYS A HB3  1 
ATOM   84   H HG2  . LYS A 1 6   ? -34.228 31.696 18.354  1.00 72.56  ? 6   LYS A HG2  1 
ATOM   85   H HG3  . LYS A 1 6   ? -33.329 32.695 19.201  1.00 72.56  ? 6   LYS A HG3  1 
ATOM   86   H HD2  . LYS A 1 6   ? -34.524 31.578 20.806  1.00 76.71  ? 6   LYS A HD2  1 
ATOM   87   H HD3  . LYS A 1 6   ? -35.314 32.950 20.667  1.00 76.71  ? 6   LYS A HD3  1 
ATOM   88   H HE2  . LYS A 1 6   ? -36.688 31.697 19.019  1.00 75.89  ? 6   LYS A HE2  1 
ATOM   89   H HE3  . LYS A 1 6   ? -36.122 30.415 19.768  1.00 75.89  ? 6   LYS A HE3  1 
ATOM   90   H HZ1  . LYS A 1 6   ? -38.157 31.026 20.591  1.00 85.23  ? 6   LYS A HZ1  1 
ATOM   91   H HZ2  . LYS A 1 6   ? -37.650 32.320 20.998  1.00 85.23  ? 6   LYS A HZ2  1 
ATOM   92   H HZ3  . LYS A 1 6   ? -37.169 31.117 21.646  1.00 85.23  ? 6   LYS A HZ3  1 
ATOM   93   N N    . ASN A 1 7   ? -35.413 33.215 15.124  1.00 42.73  ? 7   ASN A N    1 
ATOM   94   C CA   . ASN A 1 7   ? -35.651 32.244 14.063  1.00 39.34  ? 7   ASN A CA   1 
ATOM   95   C C    . ASN A 1 7   ? -34.732 32.490 12.879  1.00 41.04  ? 7   ASN A C    1 
ATOM   96   O O    . ASN A 1 7   ? -34.102 31.557 12.356  1.00 38.83  ? 7   ASN A O    1 
ATOM   97   C CB   . ASN A 1 7   ? -37.106 32.292 13.641  1.00 42.19  ? 7   ASN A CB   1 
ATOM   98   C CG   . ASN A 1 7   ? -38.046 31.771 14.735  1.00 47.55  ? 7   ASN A CG   1 
ATOM   99   O OD1  . ASN A 1 7   ? -37.648 31.002 15.645  1.00 47.09  ? 7   ASN A OD1  1 
ATOM   100  N ND2  . ASN A 1 7   ? -39.304 32.206 14.660  1.00 46.33  ? 7   ASN A ND2  1 
ATOM   101  H H    . ASN A 1 7   ? -36.047 33.781 15.257  1.00 51.33  ? 7   ASN A H    1 
ATOM   102  H HA   . ASN A 1 7   ? -35.465 31.353 14.399  1.00 47.26  ? 7   ASN A HA   1 
ATOM   103  H HB2  . ASN A 1 7   ? -37.349 33.211 13.445  1.00 50.68  ? 7   ASN A HB2  1 
ATOM   104  H HB3  . ASN A 1 7   ? -37.226 31.742 12.851  1.00 50.68  ? 7   ASN A HB3  1 
ATOM   105  H HD21 . ASN A 1 7   ? -39.537 32.742 14.029  1.00 55.64  ? 7   ASN A HD21 1 
ATOM   106  H HD22 . ASN A 1 7   ? -39.882 31.952 15.244  1.00 55.64  ? 7   ASN A HD22 1 
ATOM   107  N N    . ILE A 1 8   ? -34.629 33.749 12.447  1.00 40.67  ? 8   ILE A N    1 
ATOM   108  C CA   . ILE A 1 8   ? -33.766 34.074 11.309  1.00 38.45  ? 8   ILE A CA   1 
ATOM   109  C C    . ILE A 1 8   ? -32.320 33.697 11.594  1.00 40.71  ? 8   ILE A C    1 
ATOM   110  O O    . ILE A 1 8   ? -31.598 33.225 10.709  1.00 38.99  ? 8   ILE A O    1 
ATOM   111  C CB   . ILE A 1 8   ? -33.876 35.569 10.974  1.00 42.37  ? 8   ILE A CB   1 
ATOM   112  C CG1  . ILE A 1 8   ? -35.282 35.898 10.453  1.00 38.51  ? 8   ILE A CG1  1 
ATOM   113  C CG2  . ILE A 1 8   ? -32.700 35.944 10.060  1.00 38.88  ? 8   ILE A CG2  1 
ATOM   114  C CD1  . ILE A 1 8   ? -35.613 37.341 10.596  1.00 42.24  ? 8   ILE A CD1  1 
ATOM   115  H H    . ILE A 1 8   ? -35.041 34.423 12.788  1.00 48.85  ? 8   ILE A H    1 
ATOM   116  H HA   . ILE A 1 8   ? -34.071 33.555 10.549  1.00 46.20  ? 8   ILE A HA   1 
ATOM   117  H HB   . ILE A 1 8   ? -33.789 36.131 11.759  1.00 50.89  ? 8   ILE A HB   1 
ATOM   118  H HG12 . ILE A 1 8   ? -35.335 35.668 9.512   1.00 46.26  ? 8   ILE A HG12 1 
ATOM   119  H HG13 . ILE A 1 8   ? -35.935 35.387 10.956  1.00 46.26  ? 8   ILE A HG13 1 
ATOM   120  H HG21 . ILE A 1 8   ? -32.922 36.754 9.575   1.00 46.70  ? 8   ILE A HG21 1 
ATOM   121  H HG22 . ILE A 1 8   ? -32.541 35.218 9.436   1.00 46.70  ? 8   ILE A HG22 1 
ATOM   122  H HG23 . ILE A 1 8   ? -31.911 36.090 10.605  1.00 46.70  ? 8   ILE A HG23 1 
ATOM   123  H HD11 . ILE A 1 8   ? -35.022 37.858 10.027  1.00 50.74  ? 8   ILE A HD11 1 
ATOM   124  H HD12 . ILE A 1 8   ? -35.493 37.602 11.522  1.00 50.74  ? 8   ILE A HD12 1 
ATOM   125  H HD13 . ILE A 1 8   ? -36.536 37.481 10.330  1.00 50.74  ? 8   ILE A HD13 1 
ATOM   126  N N    . ARG A 1 9   ? -31.853 33.944 12.817  1.00 43.35  ? 9   ARG A N    1 
ATOM   127  C CA   . ARG A 1 9   ? -30.434 33.832 13.124  1.00 43.55  ? 9   ARG A CA   1 
ATOM   128  C C    . ARG A 1 9   ? -30.050 32.456 13.646  1.00 43.95  ? 9   ARG A C    1 
ATOM   129  O O    . ARG A 1 9   ? -28.889 32.063 13.515  1.00 43.69  ? 9   ARG A O    1 
ATOM   130  C CB   . ARG A 1 9   ? -30.062 34.928 14.138  1.00 46.92  ? 9   ARG A CB   1 
ATOM   131  C CG   . ARG A 1 9   ? -29.860 36.334 13.499  1.00 48.18  ? 9   ARG A CG   1 
ATOM   132  C CD   . ARG A 1 9   ? -28.739 37.132 14.248  1.00 61.46  ? 9   ARG A CD   1 
ATOM   133  N NE   . ARG A 1 9   ? -28.830 38.597 14.115  1.00 74.52  ? 9   ARG A NE   1 
ATOM   134  C CZ   . ARG A 1 9   ? -28.807 39.464 15.129  1.00 93.58  ? 9   ARG A CZ   1 
ATOM   135  N NH1  . ARG A 1 9   ? -28.713 39.038 16.387  1.00 76.45  ? 9   ARG A NH1  1 
ATOM   136  N NH2  . ARG A 1 9   ? -28.886 40.775 14.889  1.00 76.58  ? 9   ARG A NH2  1 
ATOM   137  H H    . ARG A 1 9   ? -32.340 34.179 13.486  1.00 52.07  ? 9   ARG A H    1 
ATOM   138  H HA   . ARG A 1 9   ? -29.903 33.977 12.325  1.00 52.31  ? 9   ARG A HA   1 
ATOM   139  H HB2  . ARG A 1 9   ? -30.774 35.000 14.794  1.00 56.36  ? 9   ARG A HB2  1 
ATOM   140  H HB3  . ARG A 1 9   ? -29.233 34.679 14.575  1.00 56.36  ? 9   ARG A HB3  1 
ATOM   141  H HG2  . ARG A 1 9   ? -29.598 36.233 12.571  1.00 57.87  ? 9   ARG A HG2  1 
ATOM   142  H HG3  . ARG A 1 9   ? -30.687 36.838 13.557  1.00 57.87  ? 9   ARG A HG3  1 
ATOM   143  H HD2  . ARG A 1 9   ? -28.790 36.922 15.193  1.00 73.80  ? 9   ARG A HD2  1 
ATOM   144  H HD3  . ARG A 1 9   ? -27.878 36.861 13.893  1.00 73.80  ? 9   ARG A HD3  1 
ATOM   145  H HE   . ARG A 1 9   ? -28.904 38.918 13.321  1.00 89.47  ? 9   ARG A HE   1 
ATOM   146  H HH11 . ARG A 1 9   ? -28.667 38.196 16.554  1.00 91.79  ? 9   ARG A HH11 1 
ATOM   147  H HH12 . ARG A 1 9   ? -28.699 39.605 17.034  1.00 91.79  ? 9   ARG A HH12 1 
ATOM   148  H HH21 . ARG A 1 9   ? -28.952 41.060 14.080  1.00 91.94  ? 9   ARG A HH21 1 
ATOM   149  H HH22 . ARG A 1 9   ? -28.871 41.334 15.542  1.00 91.94  ? 9   ARG A HH22 1 
ATOM   150  N N    . GLU A 1 10  ? -31.013 31.669 14.134  1.00 47.74  ? 10  GLU A N    1 
ATOM   151  C CA   . GLU A 1 10  ? -30.723 30.306 14.574  1.00 44.97  ? 10  GLU A CA   1 
ATOM   152  C C    . GLU A 1 10  ? -31.398 29.227 13.753  1.00 41.32  ? 10  GLU A C    1 
ATOM   153  O O    . GLU A 1 10  ? -30.950 28.072 13.804  1.00 44.55  ? 10  GLU A O    1 
ATOM   154  C CB   . GLU A 1 10  ? -31.133 30.125 16.033  1.00 51.75  ? 10  GLU A CB   1 
ATOM   155  C CG   . GLU A 1 10  ? -30.210 30.812 17.012  1.00 51.96  ? 10  GLU A CG   1 
ATOM   156  C CD   . GLU A 1 10  ? -30.859 31.018 18.374  1.00 54.35  ? 10  GLU A CD   1 
ATOM   157  O OE1  . GLU A 1 10  ? -30.568 32.055 18.979  1.00 53.46  ? 10  GLU A OE1  1 
ATOM   158  O OE2  . GLU A 1 10  ? -31.674 30.173 18.811  1.00 64.04  ? 10  GLU A OE2  1 
ATOM   159  H H    . GLU A 1 10  ? -31.837 31.903 14.219  1.00 57.34  ? 10  GLU A H    1 
ATOM   160  H HA   . GLU A 1 10  ? -29.766 30.166 14.505  1.00 54.01  ? 10  GLU A HA   1 
ATOM   161  H HB2  . GLU A 1 10  ? -32.022 30.493 16.156  1.00 62.15  ? 10  GLU A HB2  1 
ATOM   162  H HB3  . GLU A 1 10  ? -31.134 29.177 16.242  1.00 62.15  ? 10  GLU A HB3  1 
ATOM   163  H HG2  . GLU A 1 10  ? -29.416 30.268 17.135  1.00 62.40  ? 10  GLU A HG2  1 
ATOM   164  H HG3  . GLU A 1 10  ? -29.964 31.682 16.660  1.00 62.40  ? 10  GLU A HG3  1 
ATOM   165  N N    . GLY A 1 11  ? -32.407 29.571 12.959  1.00 42.72  ? 11  GLY A N    1 
ATOM   166  C CA   . GLY A 1 11  ? -33.273 28.586 12.332  1.00 41.12  ? 11  GLY A CA   1 
ATOM   167  C C    . GLY A 1 11  ? -34.452 28.197 13.214  1.00 38.59  ? 11  GLY A C    1 
ATOM   168  O O    . GLY A 1 11  ? -34.535 28.565 14.389  1.00 40.53  ? 11  GLY A O    1 
ATOM   169  H H    . GLY A 1 11  ? -32.612 30.383 12.767  1.00 51.31  ? 11  GLY A H    1 
ATOM   170  H HA2  . GLY A 1 11  ? -33.619 28.948 11.501  1.00 49.39  ? 11  GLY A HA2  1 
ATOM   171  H HA3  . GLY A 1 11  ? -32.760 27.786 12.138  1.00 49.39  ? 11  GLY A HA3  1 
ATOM   172  N N    . THR A 1 12  ? -35.370 27.424 12.631  1.00 39.85  ? 12  THR A N    1 
ATOM   173  C CA   . THR A 1 12  ? -36.498 26.893 13.386  1.00 37.01  ? 12  THR A CA   1 
ATOM   174  C C    . THR A 1 12  ? -36.973 25.614 12.718  1.00 44.98  ? 12  THR A C    1 
ATOM   175  O O    . THR A 1 12  ? -36.607 25.325 11.584  1.00 43.46  ? 12  THR A O    1 
ATOM   176  C CB   . THR A 1 12  ? -37.618 27.939 13.481  1.00 47.48  ? 12  THR A CB   1 
ATOM   177  O OG1  . THR A 1 12  ? -38.571 27.526 14.461  1.00 50.89  ? 12  THR A OG1  1 
ATOM   178  C CG2  . THR A 1 12  ? -38.339 28.145 12.168  1.00 42.49  ? 12  THR A CG2  1 
ATOM   179  H H    . THR A 1 12  ? -35.360 27.195 11.802  1.00 47.88  ? 12  THR A H    1 
ATOM   180  H HA   . THR A 1 12  ? -36.224 26.659 14.287  1.00 44.46  ? 12  THR A HA   1 
ATOM   181  H HB   . THR A 1 12  ? -37.214 28.786 13.725  1.00 57.03  ? 12  THR A HB   1 
ATOM   182  H HG1  . THR A 1 12  ? -38.976 28.195 14.768  1.00 61.12  ? 12  THR A HG1  1 
ATOM   183  H HG21 . THR A 1 12  ? -37.723 28.485 11.501  1.00 51.04  ? 12  THR A HG21 1 
ATOM   184  H HG22 . THR A 1 12  ? -39.062 28.781 12.282  1.00 51.04  ? 12  THR A HG22 1 
ATOM   185  H HG23 . THR A 1 12  ? -38.708 27.303 11.856  1.00 51.04  ? 12  THR A HG23 1 
ATOM   186  N N    . HIS A 1 13  ? -37.803 24.844 13.428  1.00 40.77  ? 13  HIS A N    1 
ATOM   187  C CA   . HIS A 1 13  ? -38.202 23.529 12.955  1.00 42.66  ? 13  HIS A CA   1 
ATOM   188  C C    . HIS A 1 13  ? -39.481 23.129 13.668  1.00 34.15  ? 13  HIS A C    1 
ATOM   189  O O    . HIS A 1 13  ? -39.874 23.722 14.674  1.00 37.23  ? 13  HIS A O    1 
ATOM   190  C CB   . HIS A 1 13  ? -37.094 22.473 13.183  1.00 43.92  ? 13  HIS A CB   1 
ATOM   191  C CG   . HIS A 1 13  ? -37.115 21.839 14.547  1.00 47.10  ? 13  HIS A CG   1 
ATOM   192  N ND1  . HIS A 1 13  ? -36.487 22.388 15.645  1.00 46.76  ? 13  HIS A ND1  1 
ATOM   193  C CD2  . HIS A 1 13  ? -37.676 20.680 14.978  1.00 43.89  ? 13  HIS A CD2  1 
ATOM   194  C CE1  . HIS A 1 13  ? -36.683 21.608 16.696  1.00 49.80  ? 13  HIS A CE1  1 
ATOM   195  N NE2  . HIS A 1 13  ? -37.414 20.573 16.318  1.00 41.64  ? 13  HIS A NE2  1 
ATOM   196  H H    . HIS A 1 13  ? -38.146 25.066 14.184  1.00 48.98  ? 13  HIS A H    1 
ATOM   197  H HA   . HIS A 1 13  ? -38.380 23.572 12.003  1.00 51.25  ? 13  HIS A HA   1 
ATOM   198  H HB2  . HIS A 1 13  ? -37.202 21.765 12.529  1.00 52.76  ? 13  HIS A HB2  1 
ATOM   199  H HB3  . HIS A 1 13  ? -36.231 22.900 13.071  1.00 52.76  ? 13  HIS A HB3  1 
ATOM   200  H HD1  . HIS A 1 13  ? -36.039 23.122 15.646  1.00 56.17  ? 13  HIS A HD1  1 
ATOM   201  H HD2  . HIS A 1 13  ? -38.150 20.071 14.459  1.00 52.72  ? 13  HIS A HD2  1 
ATOM   202  H HE1  . HIS A 1 13  ? -36.360 21.762 17.555  1.00 59.82  ? 13  HIS A HE1  1 
ATOM   203  N N    . VAL A 1 14  ? -40.143 22.135 13.111  1.00 38.86  ? 14  VAL A N    1 
ATOM   204  C CA   . VAL A 1 14  ? -41.240 21.464 13.794  1.00 42.71  ? 14  VAL A CA   1 
ATOM   205  C C    . VAL A 1 14  ? -41.062 19.979 13.489  1.00 41.28  ? 14  VAL A C    1 
ATOM   206  O O    . VAL A 1 14  ? -40.512 19.612 12.450  1.00 36.15  ? 14  VAL A O    1 
ATOM   207  C CB   . VAL A 1 14  ? -42.624 22.019 13.345  1.00 43.78  ? 14  VAL A CB   1 
ATOM   208  C CG1  . VAL A 1 14  ? -43.052 21.501 11.992  1.00 45.26  ? 14  VAL A CG1  1 
ATOM   209  C CG2  . VAL A 1 14  ? -43.649 21.840 14.413  1.00 58.39  ? 14  VAL A CG2  1 
ATOM   210  H H    . VAL A 1 14  ? -39.976 21.824 12.327  1.00 46.68  ? 14  VAL A H    1 
ATOM   211  H HA   . VAL A 1 14  ? -41.208 21.590 14.756  1.00 51.30  ? 14  VAL A HA   1 
ATOM   212  H HB   . VAL A 1 14  ? -42.534 22.977 13.217  1.00 52.59  ? 14  VAL A HB   1 
ATOM   213  H HG11 . VAL A 1 14  ? -43.848 21.978 11.709  1.00 54.36  ? 14  VAL A HG11 1 
ATOM   214  H HG12 . VAL A 1 14  ? -42.334 21.648 11.356  1.00 54.36  ? 14  VAL A HG12 1 
ATOM   215  H HG13 . VAL A 1 14  ? -43.242 20.553 12.063  1.00 54.36  ? 14  VAL A HG13 1 
ATOM   216  H HG21 . VAL A 1 14  ? -44.492 22.208 14.105  1.00 70.11  ? 14  VAL A HG21 1 
ATOM   217  H HG22 . VAL A 1 14  ? -43.749 20.893 14.598  1.00 70.11  ? 14  VAL A HG22 1 
ATOM   218  H HG23 . VAL A 1 14  ? -43.357 22.305 15.212  1.00 70.11  ? 14  VAL A HG23 1 
ATOM   219  N N    . LEU A 1 15  ? -41.454 19.129 14.428  1.00 41.42  ? 15  LEU A N    1 
ATOM   220  C CA   . LEU A 1 15  ? -41.531 17.703 14.209  1.00 39.19  ? 15  LEU A CA   1 
ATOM   221  C C    . LEU A 1 15  ? -42.961 17.352 13.842  1.00 42.86  ? 15  LEU A C    1 
ATOM   222  O O    . LEU A 1 15  ? -43.902 17.774 14.507  1.00 46.15  ? 15  LEU A O    1 
ATOM   223  C CB   . LEU A 1 15  ? -41.108 16.924 15.464  1.00 50.24  ? 15  LEU A CB   1 
ATOM   224  C CG   . LEU A 1 15  ? -39.700 17.056 16.043  1.00 53.53  ? 15  LEU A CG   1 
ATOM   225  C CD1  . LEU A 1 15  ? -39.501 16.033 17.178  1.00 53.18  ? 15  LEU A CD1  1 
ATOM   226  C CD2  . LEU A 1 15  ? -38.662 16.844 14.976  1.00 50.73  ? 15  LEU A CD2  1 
ATOM   227  H H    . LEU A 1 15  ? -41.687 19.366 15.221  1.00 49.75  ? 15  LEU A H    1 
ATOM   228  H HA   . LEU A 1 15  ? -40.937 17.447 13.485  1.00 47.07  ? 15  LEU A HA   1 
ATOM   229  H HB2  . LEU A 1 15  ? -41.712 17.187 16.176  1.00 60.34  ? 15  LEU A HB2  1 
ATOM   230  H HB3  . LEU A 1 15  ? -41.223 15.982 15.263  1.00 60.34  ? 15  LEU A HB3  1 
ATOM   231  H HG   . LEU A 1 15  ? -39.589 17.951 16.400  1.00 64.29  ? 15  LEU A HG   1 
ATOM   232  H HD11 . LEU A 1 15  ? -38.559 15.993 17.405  1.00 63.86  ? 15  LEU A HD11 1 
ATOM   233  H HD12 . LEU A 1 15  ? -40.015 16.315 17.951  1.00 63.86  ? 15  LEU A HD12 1 
ATOM   234  H HD13 . LEU A 1 15  ? -39.807 15.163 16.877  1.00 63.86  ? 15  LEU A HD13 1 
ATOM   235  H HD21 . LEU A 1 15  ? -38.800 15.975 14.568  1.00 60.92  ? 15  LEU A HD21 1 
ATOM   236  H HD22 . LEU A 1 15  ? -37.781 16.883 15.380  1.00 60.92  ? 15  LEU A HD22 1 
ATOM   237  H HD23 . LEU A 1 15  ? -38.750 17.541 14.307  1.00 60.92  ? 15  LEU A HD23 1 
ATOM   238  N N    . LEU A 1 16  ? -43.133 16.626 12.766  1.00 32.85  ? 16  LEU A N    1 
ATOM   239  C CA   . LEU A 1 16  ? -44.473 16.223 12.418  1.00 43.48  ? 16  LEU A CA   1 
ATOM   240  C C    . LEU A 1 16  ? -44.678 14.781 12.812  1.00 36.96  ? 16  LEU A C    1 
ATOM   241  O O    . LEU A 1 16  ? -43.711 14.011 12.938  1.00 43.70  ? 16  LEU A O    1 
ATOM   242  C CB   . LEU A 1 16  ? -44.739 16.385 10.911  1.00 40.70  ? 16  LEU A CB   1 
ATOM   243  C CG   . LEU A 1 16  ? -44.428 17.753 10.272  1.00 45.43  ? 16  LEU A CG   1 
ATOM   244  C CD1  . LEU A 1 16  ? -44.566 17.800 8.783   1.00 35.27  ? 16  LEU A CD1  1 
ATOM   245  C CD2  . LEU A 1 16  ? -45.379 18.718 10.958  1.00 45.51  ? 16  LEU A CD2  1 
ATOM   246  H H    . LEU A 1 16  ? -42.509 16.360 12.237  1.00 39.47  ? 16  LEU A H    1 
ATOM   247  H HA   . LEU A 1 16  ? -45.112 16.787 12.882  1.00 52.23  ? 16  LEU A HA   1 
ATOM   248  H HB2  . LEU A 1 16  ? -44.199 15.728 10.443  1.00 48.89  ? 16  LEU A HB2  1 
ATOM   249  H HB3  . LEU A 1 16  ? -45.680 16.211 10.756  1.00 48.89  ? 16  LEU A HB3  1 
ATOM   250  H HG   . LEU A 1 16  ? -43.495 17.985 10.398  1.00 54.57  ? 16  LEU A HG   1 
ATOM   251  H HD11 . LEU A 1 16  ? -44.393 18.704 8.479   1.00 42.38  ? 16  LEU A HD11 1 
ATOM   252  H HD12 . LEU A 1 16  ? -43.925 17.189 8.387   1.00 42.38  ? 16  LEU A HD12 1 
ATOM   253  H HD13 . LEU A 1 16  ? -45.467 17.536 8.541   1.00 42.38  ? 16  LEU A HD13 1 
ATOM   254  H HD21 . LEU A 1 16  ? -46.178 18.238 11.226  1.00 54.66  ? 16  LEU A HD21 1 
ATOM   255  H HD22 . LEU A 1 16  ? -45.611 19.427 10.338  1.00 54.66  ? 16  LEU A HD22 1 
ATOM   256  H HD23 . LEU A 1 16  ? -44.941 19.092 11.739  1.00 54.66  ? 16  LEU A HD23 1 
ATOM   257  N N    . PRO A 1 17  ? -45.927 14.334 12.947  1.00 42.81  ? 17  PRO A N    1 
ATOM   258  C CA   . PRO A 1 17  ? -46.214 13.012 13.418  1.00 46.47  ? 17  PRO A CA   1 
ATOM   259  C C    . PRO A 1 17  ? -46.282 11.955 12.289  1.00 44.07  ? 17  PRO A C    1 
ATOM   260  O O    . PRO A 1 17  ? -46.302 12.268 11.097  1.00 43.34  ? 17  PRO A O    1 
ATOM   261  C CB   . PRO A 1 17  ? -47.583 13.135 14.106  1.00 50.84  ? 17  PRO A CB   1 
ATOM   262  C CG   . PRO A 1 17  ? -48.269 14.332 13.436  1.00 49.10  ? 17  PRO A CG   1 
ATOM   263  C CD   . PRO A 1 17  ? -47.158 15.172 12.767  1.00 41.68  ? 17  PRO A CD   1 
ATOM   264  H HA   . PRO A 1 17  ? -45.536 12.758 14.063  1.00 55.82  ? 17  PRO A HA   1 
ATOM   265  H HB2  . PRO A 1 17  ? -48.094 12.322 13.970  1.00 61.06  ? 17  PRO A HB2  1 
ATOM   266  H HB3  . PRO A 1 17  ? -47.460 13.294 15.055  1.00 61.06  ? 17  PRO A HB3  1 
ATOM   267  H HG2  . PRO A 1 17  ? -48.899 14.012 12.772  1.00 58.97  ? 17  PRO A HG2  1 
ATOM   268  H HG3  . PRO A 1 17  ? -48.733 14.855 14.108  1.00 58.97  ? 17  PRO A HG3  1 
ATOM   269  H HD2  . PRO A 1 17  ? -47.347 15.307 11.825  1.00 50.06  ? 17  PRO A HD2  1 
ATOM   270  H HD3  . PRO A 1 17  ? -47.059 16.029 13.212  1.00 50.06  ? 17  PRO A HD3  1 
ATOM   271  N N    . PHE A 1 18  ? -46.309 10.715 12.722  1.00 44.97  ? 18  PHE A N    1 
ATOM   272  C CA   . PHE A 1 18  ? -46.416 9.574  11.828  1.00 46.21  ? 18  PHE A CA   1 
ATOM   273  C C    . PHE A 1 18  ? -47.865 9.106  11.819  1.00 48.80  ? 18  PHE A C    1 
ATOM   274  O O    . PHE A 1 18  ? -48.519 9.064  12.864  1.00 52.07  ? 18  PHE A O    1 
ATOM   275  C CB   . PHE A 1 18  ? -45.477 8.458  12.297  1.00 49.33  ? 18  PHE A CB   1 
ATOM   276  C CG   . PHE A 1 18  ? -45.660 7.188  11.573  1.00 49.47  ? 18  PHE A CG   1 
ATOM   277  C CD1  . PHE A 1 18  ? -45.516 7.122  10.204  1.00 48.49  ? 18  PHE A CD1  1 
ATOM   278  C CD2  . PHE A 1 18  ? -45.968 6.054  12.254  1.00 48.97  ? 18  PHE A CD2  1 
ATOM   279  C CE1  . PHE A 1 18  ? -45.710 5.944  9.532   1.00 53.24  ? 18  PHE A CE1  1 
ATOM   280  C CE2  . PHE A 1 18  ? -46.132 4.864  11.592  1.00 48.86  ? 18  PHE A CE2  1 
ATOM   281  C CZ   . PHE A 1 18  ? -46.010 4.800  10.235  1.00 51.14  ? 18  PHE A CZ   1 
ATOM   282  H H    . PHE A 1 18  ? -46.266 10.498 13.553  1.00 54.01  ? 18  PHE A H    1 
ATOM   283  H HA   . PHE A 1 18  ? -46.166 9.806  10.920  1.00 55.51  ? 18  PHE A HA   1 
ATOM   284  H HB2  . PHE A 1 18  ? -44.560 8.746  12.164  1.00 59.24  ? 18  PHE A HB2  1 
ATOM   285  H HB3  . PHE A 1 18  ? -45.638 8.289  13.238  1.00 59.24  ? 18  PHE A HB3  1 
ATOM   286  H HD1  . PHE A 1 18  ? -45.283 7.888  9.730   1.00 58.24  ? 18  PHE A HD1  1 
ATOM   287  H HD2  . PHE A 1 18  ? -46.069 6.085  13.178  1.00 58.81  ? 18  PHE A HD2  1 
ATOM   288  H HE1  . PHE A 1 18  ? -45.640 5.918  8.605   1.00 63.94  ? 18  PHE A HE1  1 
ATOM   289  H HE2  . PHE A 1 18  ? -46.328 4.093  12.073  1.00 58.68  ? 18  PHE A HE2  1 
ATOM   290  H HZ   . PHE A 1 18  ? -46.128 3.992  9.790   1.00 61.42  ? 18  PHE A HZ   1 
ATOM   291  N N    . TYR A 1 19  ? -48.377 8.819  10.642  1.00 49.01  ? 19  TYR A N    1 
ATOM   292  C CA   . TYR A 1 19  ? -49.760 8.388  10.484  1.00 50.33  ? 19  TYR A CA   1 
ATOM   293  C C    . TYR A 1 19  ? -49.713 7.008  9.851   1.00 54.79  ? 19  TYR A C    1 
ATOM   294  O O    . TYR A 1 19  ? -49.325 6.875  8.680   1.00 47.15  ? 19  TYR A O    1 
ATOM   295  C CB   . TYR A 1 19  ? -50.564 9.356  9.618   1.00 45.77  ? 19  TYR A CB   1 
ATOM   296  C CG   . TYR A 1 19  ? -50.905 10.714 10.233  1.00 45.49  ? 19  TYR A CG   1 
ATOM   297  C CD1  . TYR A 1 19  ? -50.018 11.776 10.155  1.00 46.57  ? 19  TYR A CD1  1 
ATOM   298  C CD2  . TYR A 1 19  ? -52.142 10.942 10.853  1.00 52.99  ? 19  TYR A CD2  1 
ATOM   299  C CE1  . TYR A 1 19  ? -50.319 13.019 10.703  1.00 45.27  ? 19  TYR A CE1  1 
ATOM   300  C CE2  . TYR A 1 19  ? -52.470 12.191 11.386  1.00 49.93  ? 19  TYR A CE2  1 
ATOM   301  C CZ   . TYR A 1 19  ? -51.552 13.226 11.298  1.00 56.06  ? 19  TYR A CZ   1 
ATOM   302  O OH   . TYR A 1 19  ? -51.842 14.465 11.850  1.00 55.87  ? 19  TYR A OH   1 
ATOM   303  N N    . GLU A 1 20  ? -50.081 5.980  10.632  1.00 53.62  ? 20  GLU A N    1 
ATOM   304  C CA   . GLU A 1 20  ? -50.012 4.618  10.115  1.00 57.06  ? 20  GLU A CA   1 
ATOM   305  C C    . GLU A 1 20  ? -50.777 4.509  8.816   1.00 52.88  ? 20  GLU A C    1 
ATOM   306  O O    . GLU A 1 20  ? -50.370 3.775  7.906   1.00 49.24  ? 20  GLU A O    1 
ATOM   307  C CB   . GLU A 1 20  ? -50.589 3.594  11.102  1.00 61.68  ? 20  GLU A CB   1 
ATOM   308  C CG   . GLU A 1 20  ? -50.091 2.134  10.864  1.00 73.29  ? 20  GLU A CG   1 
ATOM   309  C CD   . GLU A 1 20  ? -50.705 1.402  9.633   1.00 69.27  ? 20  GLU A CD   1 
ATOM   310  O OE1  . GLU A 1 20  ? -49.943 0.767  8.868   1.00 68.51  ? 20  GLU A OE1  1 
ATOM   311  O OE2  . GLU A 1 20  ? -51.946 1.418  9.443   1.00 71.31  ? 20  GLU A OE2  1 
ATOM   312  H H    . GLU A 1 20  ? -50.365 6.049  11.441  1.00 64.40  ? 20  GLU A H    1 
ATOM   313  H HA   . GLU A 1 20  ? -49.075 4.406  9.984   1.00 68.52  ? 20  GLU A HA   1 
ATOM   314  H HB2  . GLU A 1 20  ? -50.332 3.851  12.002  1.00 74.07  ? 20  GLU A HB2  1 
ATOM   315  H HB3  . GLU A 1 20  ? -51.556 3.594  11.021  1.00 74.07  ? 20  GLU A HB3  1 
ATOM   316  H HG2  . GLU A 1 20  ? -49.130 2.157  10.735  1.00 88.00  ? 20  GLU A HG2  1 
ATOM   317  H HG3  . GLU A 1 20  ? -50.308 1.606  11.649  1.00 88.00  ? 20  GLU A HG3  1 
ATOM   318  N N    . THR A 1 21  ? -51.901 5.213  8.723   1.00 49.18  ? 21  THR A N    1 
ATOM   319  C CA   . THR A 1 21  ? -52.880 5.002  7.657   1.00 53.73  ? 21  THR A CA   1 
ATOM   320  C C    . THR A 1 21  ? -52.737 6.095  6.615   1.00 48.46  ? 21  THR A C    1 
ATOM   321  O O    . THR A 1 21  ? -52.947 7.275  6.911   1.00 46.28  ? 21  THR A O    1 
ATOM   322  C CB   . THR A 1 21  ? -54.305 4.988  8.195   1.00 45.03  ? 21  THR A CB   1 
ATOM   323  O OG1  . THR A 1 21  ? -54.359 4.050  9.261   1.00 56.43  ? 21  THR A OG1  1 
ATOM   324  C CG2  . THR A 1 21  ? -55.288 4.597  7.115   1.00 40.83  ? 21  THR A CG2  1 
ATOM   325  H H    . THR A 1 21  ? -52.125 5.832  9.276   1.00 59.07  ? 21  THR A H    1 
ATOM   326  H HA   . THR A 1 21  ? -52.699 4.144  7.244   1.00 64.53  ? 21  THR A HA   1 
ATOM   327  H HB   . THR A 1 21  ? -54.560 5.871  8.508   1.00 54.08  ? 21  THR A HB   1 
ATOM   328  H HG1  . THR A 1 21  ? -55.072 4.149  9.695   1.00 67.76  ? 21  THR A HG1  1 
ATOM   329  H HG21 . THR A 1 21  ? -55.335 5.293  6.441   1.00 49.04  ? 21  THR A HG21 1 
ATOM   330  H HG22 . THR A 1 21  ? -56.170 4.470  7.499   1.00 49.04  ? 21  THR A HG22 1 
ATOM   331  H HG23 . THR A 1 21  ? -55.006 3.769  6.694   1.00 49.04  ? 21  THR A HG23 1 
ATOM   332  N N    . LEU A 1 22  ? -52.387 5.690  5.416   1.00 50.08  ? 22  LEU A N    1 
ATOM   333  C CA   . LEU A 1 22  ? -52.271 6.595  4.307   1.00 51.10  ? 22  LEU A CA   1 
ATOM   334  C C    . LEU A 1 22  ? -53.661 7.073  3.947   1.00 51.83  ? 22  LEU A C    1 
ATOM   335  O O    . LEU A 1 22  ? -54.598 6.261  3.888   1.00 52.38  ? 22  LEU A O    1 
ATOM   336  C CB   . LEU A 1 22  ? -51.631 5.879  3.136   1.00 52.16  ? 22  LEU A CB   1 
ATOM   337  C CG   . LEU A 1 22  ? -50.810 6.559  2.044   1.00 58.48  ? 22  LEU A CG   1 
ATOM   338  C CD1  . LEU A 1 22  ? -49.706 7.450  2.573   1.00 52.07  ? 22  LEU A CD1  1 
ATOM   339  C CD2  . LEU A 1 22  ? -50.240 5.413  1.140   1.00 56.17  ? 22  LEU A CD2  1 
ATOM   340  H H    . LEU A 1 22  ? -52.206 4.873  5.215   1.00 60.15  ? 22  LEU A H    1 
ATOM   341  H HA   . LEU A 1 22  ? -51.717 7.360  4.529   1.00 61.37  ? 22  LEU A HA   1 
ATOM   342  H HB2  . LEU A 1 22  ? -51.034 5.218  3.520   1.00 62.64  ? 22  LEU A HB2  1 
ATOM   343  H HB3  . LEU A 1 22  ? -52.355 5.438  2.664   1.00 62.64  ? 22  LEU A HB3  1 
ATOM   344  H HG   . LEU A 1 22  ? -51.372 7.165  1.536   1.00 70.22  ? 22  LEU A HG   1 
ATOM   345  H HD11 . LEU A 1 22  ? -50.079 8.061  3.228   1.00 62.53  ? 22  LEU A HD11 1 
ATOM   346  H HD12 . LEU A 1 22  ? -49.024 6.898  2.986   1.00 62.53  ? 22  LEU A HD12 1 
ATOM   347  H HD13 . LEU A 1 22  ? -49.323 7.951  1.835   1.00 62.53  ? 22  LEU A HD13 1 
ATOM   348  H HD21 . LEU A 1 22  ? -50.923 5.141  0.507   1.00 67.45  ? 22  LEU A HD21 1 
ATOM   349  H HD22 . LEU A 1 22  ? -49.992 4.662  1.702   1.00 67.45  ? 22  LEU A HD22 1 
ATOM   350  H HD23 . LEU A 1 22  ? -49.461 5.742  0.666   1.00 67.45  ? 22  LEU A HD23 1 
ATOM   351  N N    . PRO A 1 23  ? -53.865 8.361  3.752   1.00 53.01  ? 23  PRO A N    1 
ATOM   352  C CA   . PRO A 1 23  ? -55.150 8.822  3.245   1.00 52.05  ? 23  PRO A CA   1 
ATOM   353  C C    . PRO A 1 23  ? -55.413 8.227  1.880   1.00 57.30  ? 23  PRO A C    1 
ATOM   354  O O    . PRO A 1 23  ? -54.524 7.672  1.232   1.00 56.65  ? 23  PRO A O    1 
ATOM   355  C CB   . PRO A 1 23  ? -55.007 10.334 3.162   1.00 52.29  ? 23  PRO A CB   1 
ATOM   356  C CG   . PRO A 1 23  ? -53.613 10.659 3.373   1.00 51.52  ? 23  PRO A CG   1 
ATOM   357  C CD   . PRO A 1 23  ? -52.959 9.472  4.060   1.00 55.83  ? 23  PRO A CD   1 
ATOM   358  H HA   . PRO A 1 23  ? -55.865 8.606  3.864   1.00 62.51  ? 23  PRO A HA   1 
ATOM   359  H HB2  . PRO A 1 23  ? -55.294 10.633 2.285   1.00 62.80  ? 23  PRO A HB2  1 
ATOM   360  H HB3  . PRO A 1 23  ? -55.556 10.743 3.849   1.00 62.80  ? 23  PRO A HB3  1 
ATOM   361  H HG2  . PRO A 1 23  ? -53.191 10.826 2.516   1.00 61.88  ? 23  PRO A HG2  1 
ATOM   362  H HG3  . PRO A 1 23  ? -53.551 11.449 3.933   1.00 61.88  ? 23  PRO A HG3  1 
ATOM   363  H HD2  . PRO A 1 23  ? -52.075 9.307  3.697   1.00 67.04  ? 23  PRO A HD2  1 
ATOM   364  H HD3  . PRO A 1 23  ? -52.903 9.616  5.018   1.00 67.04  ? 23  PRO A HD3  1 
ATOM   365  N N    . GLU A 1 24  ? -56.666 8.374  1.453   1.00 54.45  ? 24  GLU A N    1 
ATOM   366  C CA   . GLU A 1 24  ? -57.096 7.930  0.139   1.00 55.21  ? 24  GLU A CA   1 
ATOM   367  C C    . GLU A 1 24  ? -56.382 8.751  -0.915  1.00 57.63  ? 24  GLU A C    1 
ATOM   368  O O    . GLU A 1 24  ? -56.468 9.982  -0.916  1.00 62.23  ? 24  GLU A O    1 
ATOM   369  C CB   . GLU A 1 24  ? -58.612 8.092  0.004   1.00 71.85  ? 24  GLU A CB   1 
ATOM   370  C CG   . GLU A 1 24  ? -59.237 7.457  -1.268  1.00 76.06  ? 24  GLU A CG   1 
ATOM   371  C CD   . GLU A 1 24  ? -60.759 7.593  -1.328  1.00 83.20  ? 24  GLU A CD   1 
ATOM   372  O OE1  . GLU A 1 24  ? -61.287 7.868  -2.434  1.00 83.78  ? 24  GLU A OE1  1 
ATOM   373  O OE2  . GLU A 1 24  ? -61.422 7.400  -0.283  1.00 107.24 ? 24  GLU A OE2  1 
ATOM   374  H H    . GLU A 1 24  ? -57.294 8.735  1.916   1.00 65.39  ? 24  GLU A H    1 
ATOM   375  H HA   . GLU A 1 24  ? -56.884 6.992  0.016   1.00 66.31  ? 24  GLU A HA   1 
ATOM   376  H HB2  . GLU A 1 24  ? -59.034 7.676  0.772   1.00 86.27  ? 24  GLU A HB2  1 
ATOM   377  H HB3  . GLU A 1 24  ? -58.818 9.040  -0.015  1.00 86.27  ? 24  GLU A HB3  1 
ATOM   378  H HG2  . GLU A 1 24  ? -58.868 7.894  -2.051  1.00 91.32  ? 24  GLU A HG2  1 
ATOM   379  H HG3  . GLU A 1 24  ? -59.023 6.511  -1.284  1.00 91.32  ? 24  GLU A HG3  1 
ATOM   380  N N    . LEU A 1 25  ? -55.698 8.072  -1.818  1.00 61.26  ? 25  LEU A N    1 
ATOM   381  C CA   . LEU A 1 25  ? -54.949 8.725  -2.872  1.00 57.56  ? 25  LEU A CA   1 
ATOM   382  C C    . LEU A 1 25  ? -55.819 8.925  -4.104  1.00 56.35  ? 25  LEU A C    1 
ATOM   383  O O    . LEU A 1 25  ? -56.724 8.139  -4.396  1.00 50.89  ? 25  LEU A O    1 
ATOM   384  C CB   . LEU A 1 25  ? -53.712 7.903  -3.234  1.00 53.09  ? 25  LEU A CB   1 
ATOM   385  C CG   . LEU A 1 25  ? -52.860 7.453  -2.049  1.00 53.11  ? 25  LEU A CG   1 
ATOM   386  C CD1  . LEU A 1 25  ? -51.743 6.522  -2.486  1.00 56.71  ? 25  LEU A CD1  1 
ATOM   387  C CD2  . LEU A 1 25  ? -52.288 8.666  -1.321  1.00 59.49  ? 25  LEU A CD2  1 
ATOM   388  H H    . LEU A 1 25  ? -55.651 7.213  -1.841  1.00 73.56  ? 25  LEU A H    1 
ATOM   389  H HA   . LEU A 1 25  ? -54.656 9.598  -2.568  1.00 69.12  ? 25  LEU A HA   1 
ATOM   390  H HB2  . LEU A 1 25  ? -54.002 7.105  -3.703  1.00 63.76  ? 25  LEU A HB2  1 
ATOM   391  H HB3  . LEU A 1 25  ? -53.146 8.440  -3.810  1.00 63.76  ? 25  LEU A HB3  1 
ATOM   392  H HG   . LEU A 1 25  ? -53.424 6.957  -1.435  1.00 63.78  ? 25  LEU A HG   1 
ATOM   393  H HD11 . LEU A 1 25  ? -51.244 6.238  -1.704  1.00 68.10  ? 25  LEU A HD11 1 
ATOM   394  H HD12 . LEU A 1 25  ? -52.129 5.751  -2.930  1.00 68.10  ? 25  LEU A HD12 1 
ATOM   395  H HD13 . LEU A 1 25  ? -51.157 6.997  -3.097  1.00 68.10  ? 25  LEU A HD13 1 
ATOM   396  H HD21 . LEU A 1 25  ? -51.800 9.214  -1.956  1.00 71.44  ? 25  LEU A HD21 1 
ATOM   397  H HD22 . LEU A 1 25  ? -51.691 8.361  -0.620  1.00 71.44  ? 25  LEU A HD22 1 
ATOM   398  H HD23 . LEU A 1 25  ? -53.017 9.176  -0.936  1.00 71.44  ? 25  LEU A HD23 1 
ATOM   399  N N    . ASN A 1 26  ? -55.515 9.981  -4.838  1.00 53.76  ? 26  ASN A N    1 
ATOM   400  C CA   . ASN A 1 26  ? -56.231 10.300 -6.056  1.00 50.69  ? 26  ASN A CA   1 
ATOM   401  C C    . ASN A 1 26  ? -55.385 11.327 -6.800  1.00 56.70  ? 26  ASN A C    1 
ATOM   402  O O    . ASN A 1 26  ? -55.820 12.456 -7.057  1.00 55.21  ? 26  ASN A O    1 
ATOM   403  C CB   . ASN A 1 26  ? -57.626 10.830 -5.767  1.00 58.59  ? 26  ASN A CB   1 
ATOM   404  C CG   . ASN A 1 26  ? -58.347 11.239 -7.022  1.00 64.55  ? 26  ASN A CG   1 
ATOM   405  O OD1  . ASN A 1 26  ? -58.257 10.574 -8.057  1.00 66.84  ? 26  ASN A OD1  1 
ATOM   406  N ND2  . ASN A 1 26  ? -59.048 12.356 -6.955  1.00 67.39  ? 26  ASN A ND2  1 
ATOM   407  H H    . ASN A 1 26  ? -54.887 10.536 -4.648  1.00 64.57  ? 26  ASN A H    1 
ATOM   408  H HA   . ASN A 1 26  ? -56.371 9.511  -6.603  1.00 60.88  ? 26  ASN A HA   1 
ATOM   409  H HB2  . ASN A 1 26  ? -58.146 10.136 -5.331  1.00 70.36  ? 26  ASN A HB2  1 
ATOM   410  H HB3  . ASN A 1 26  ? -57.559 11.606 -5.189  1.00 70.36  ? 26  ASN A HB3  1 
ATOM   411  H HD21 . ASN A 1 26  ? -59.073 12.804 -6.222  1.00 80.92  ? 26  ASN A HD21 1 
ATOM   412  H HD22 . ASN A 1 26  ? -59.479 12.635 -7.645  1.00 80.92  ? 26  ASN A HD22 1 
ATOM   413  N N    . LEU A 1 27  ? -54.159 10.928 -7.130  1.00 50.98  ? 27  LEU A N    1 
ATOM   414  C CA   . LEU A 1 27  ? -53.268 11.727 -7.950  1.00 53.07  ? 27  LEU A CA   1 
ATOM   415  C C    . LEU A 1 27  ? -53.953 12.186 -9.224  1.00 50.11  ? 27  LEU A C    1 
ATOM   416  O O    . LEU A 1 27  ? -54.573 11.385 -9.920  1.00 51.07  ? 27  LEU A O    1 
ATOM   417  C CB   . LEU A 1 27  ? -52.039 10.902 -8.307  1.00 55.30  ? 27  LEU A CB   1 
ATOM   418  C CG   . LEU A 1 27  ? -51.022 11.575 -9.231  1.00 50.48  ? 27  LEU A CG   1 
ATOM   419  C CD1  . LEU A 1 27  ? -50.560 12.898 -8.703  1.00 44.27  ? 27  LEU A CD1  1 
ATOM   420  C CD2  . LEU A 1 27  ? -49.853 10.584 -9.445  1.00 49.98  ? 27  LEU A CD2  1 
ATOM   421  H H    . LEU A 1 27  ? -53.816 10.180 -6.883  1.00 61.22  ? 27  LEU A H    1 
ATOM   422  H HA   . LEU A 1 27  ? -52.994 12.511 -7.450  1.00 63.74  ? 27  LEU A HA   1 
ATOM   423  H HB2  . LEU A 1 27  ? -51.575 10.679 -7.485  1.00 66.41  ? 27  LEU A HB2  1 
ATOM   424  H HB3  . LEU A 1 27  ? -52.337 10.092 -8.750  1.00 66.41  ? 27  LEU A HB3  1 
ATOM   425  H HG   . LEU A 1 27  ? -51.429 11.783 -10.086 1.00 60.63  ? 27  LEU A HG   1 
ATOM   426  H HD11 . LEU A 1 27  ? -51.303 13.522 -8.722  1.00 53.17  ? 27  LEU A HD11 1 
ATOM   427  H HD12 . LEU A 1 27  ? -50.247 12.784 -7.792  1.00 53.17  ? 27  LEU A HD12 1 
ATOM   428  H HD13 . LEU A 1 27  ? -49.839 13.227 -9.262  1.00 53.17  ? 27  LEU A HD13 1 
ATOM   429  H HD21 . LEU A 1 27  ? -49.142 11.034 -9.926  1.00 60.03  ? 27  LEU A HD21 1 
ATOM   430  H HD22 . LEU A 1 27  ? -50.172 9.826  -9.959  1.00 60.03  ? 27  LEU A HD22 1 
ATOM   431  H HD23 . LEU A 1 27  ? -49.530 10.285 -8.580  1.00 60.03  ? 27  LEU A HD23 1 
ATOM   432  N N    . SER A 1 28  ? -53.753 13.464 -9.560  1.00 48.54  ? 28  SER A N    1 
ATOM   433  C CA   . SER A 1 28  ? -54.284 14.139 -10.743 1.00 49.15  ? 28  SER A CA   1 
ATOM   434  C C    . SER A 1 28  ? -53.213 15.123 -11.186 1.00 54.52  ? 28  SER A C    1 
ATOM   435  O O    . SER A 1 28  ? -52.762 15.915 -10.352 1.00 48.23  ? 28  SER A O    1 
ATOM   436  C CB   . SER A 1 28  ? -55.571 14.903 -10.407 1.00 48.40  ? 28  SER A CB   1 
ATOM   437  O OG   . SER A 1 28  ? -56.111 15.533 -11.552 1.00 53.32  ? 28  SER A OG   1 
ATOM   438  H H    . SER A 1 28  ? -53.277 13.998 -9.082  1.00 58.30  ? 28  SER A H    1 
ATOM   439  H HA   . SER A 1 28  ? -54.485 13.505 -11.450 1.00 59.03  ? 28  SER A HA   1 
ATOM   440  H HB2  . SER A 1 28  ? -56.225 14.278 -10.056 1.00 58.13  ? 28  SER A HB2  1 
ATOM   441  H HB3  . SER A 1 28  ? -55.369 15.580 -9.742  1.00 58.13  ? 28  SER A HB3  1 
ATOM   442  H HG   . SER A 1 28  ? -56.916 15.732 -11.417 1.00 64.04  ? 28  SER A HG   1 
ATOM   443  N N    . LEU A 1 29  ? -52.787 15.090 -12.455 1.00 49.16  ? 29  LEU A N    1 
ATOM   444  C CA   . LEU A 1 29  ? -51.679 15.940 -12.899 1.00 53.07  ? 29  LEU A CA   1 
ATOM   445  C C    . LEU A 1 29  ? -52.195 17.076 -13.773 1.00 52.74  ? 29  LEU A C    1 
ATOM   446  O O    . LEU A 1 29  ? -53.036 16.866 -14.647 1.00 64.17  ? 29  LEU A O    1 
ATOM   447  C CB   . LEU A 1 29  ? -50.604 15.143 -13.650 1.00 46.88  ? 29  LEU A CB   1 
ATOM   448  C CG   . LEU A 1 29  ? -49.945 14.029 -12.815 1.00 48.86  ? 29  LEU A CG   1 
ATOM   449  C CD1  . LEU A 1 29  ? -49.352 12.913 -13.697 1.00 56.43  ? 29  LEU A CD1  1 
ATOM   450  C CD2  . LEU A 1 29  ? -48.869 14.520 -11.852 1.00 38.67  ? 29  LEU A CD2  1 
ATOM   451  H H    . LEU A 1 29  ? -53.121 14.589 -13.068 1.00 59.04  ? 29  LEU A H    1 
ATOM   452  H HA   . LEU A 1 29  ? -51.268 16.329 -12.111 1.00 63.74  ? 29  LEU A HA   1 
ATOM   453  H HB2  . LEU A 1 29  ? -51.011 14.728 -14.426 1.00 56.30  ? 29  LEU A HB2  1 
ATOM   454  H HB3  . LEU A 1 29  ? -49.904 15.754 -13.930 1.00 56.30  ? 29  LEU A HB3  1 
ATOM   455  H HG   . LEU A 1 29  ? -50.668 13.668 -12.278 1.00 58.68  ? 29  LEU A HG   1 
ATOM   456  H HD11 . LEU A 1 29  ? -50.030 12.610 -14.322 1.00 67.77  ? 29  LEU A HD11 1 
ATOM   457  H HD12 . LEU A 1 29  ? -49.072 12.177 -13.131 1.00 67.77  ? 29  LEU A HD12 1 
ATOM   458  H HD13 . LEU A 1 29  ? -48.590 13.266 -14.182 1.00 67.77  ? 29  LEU A HD13 1 
ATOM   459  H HD21 . LEU A 1 29  ? -48.481 13.756 -11.396 1.00 46.45  ? 29  LEU A HD21 1 
ATOM   460  H HD22 . LEU A 1 29  ? -48.184 14.987 -12.355 1.00 46.45  ? 29  LEU A HD22 1 
ATOM   461  H HD23 . LEU A 1 29  ? -49.273 15.120 -11.206 1.00 46.45  ? 29  LEU A HD23 1 
ATOM   462  N N    . GLY A 1 30  ? -51.693 18.279 -13.529 1.00 50.78  ? 30  GLY A N    1 
ATOM   463  C CA   . GLY A 1 30  ? -52.015 19.421 -14.365 1.00 48.61  ? 30  GLY A CA   1 
ATOM   464  C C    . GLY A 1 30  ? -52.188 20.718 -13.597 1.00 60.14  ? 30  GLY A C    1 
ATOM   465  O O    . GLY A 1 30  ? -51.728 21.792 -14.029 1.00 51.73  ? 30  GLY A O    1 
ATOM   466  H H    . GLY A 1 30  ? -51.159 18.460 -12.880 1.00 60.98  ? 30  GLY A H    1 
ATOM   467  H HA2  . GLY A 1 30  ? -51.303 19.549 -15.011 1.00 58.38  ? 30  GLY A HA2  1 
ATOM   468  H HA3  . GLY A 1 30  ? -52.842 19.241 -14.838 1.00 58.38  ? 30  GLY A HA3  1 
ATOM   469  N N    . LYS A 1 31  ? -52.895 20.635 -12.463 1.00 58.22  ? 31  LYS A N    1 
ATOM   470  C CA   . LYS A 1 31  ? -53.300 21.815 -11.696 1.00 57.87  ? 31  LYS A CA   1 
ATOM   471  C C    . LYS A 1 31  ? -53.200 21.472 -10.215 1.00 51.11  ? 31  LYS A C    1 
ATOM   472  O O    . LYS A 1 31  ? -53.485 20.346 -9.791  1.00 49.93  ? 31  LYS A O    1 
ATOM   473  C CB   . LYS A 1 31  ? -54.710 22.270 -12.142 1.00 55.40  ? 31  LYS A CB   1 
ATOM   474  C CG   . LYS A 1 31  ? -54.504 22.730 -13.604 1.00 67.59  ? 31  LYS A CG   1 
ATOM   475  C CD   . LYS A 1 31  ? -55.707 23.204 -14.422 1.00 69.14  ? 31  LYS A CD   1 
ATOM   476  C CE   . LYS A 1 31  ? -55.705 22.620 -15.890 1.00 79.08  ? 31  LYS A CE   1 
ATOM   477  N NZ   . LYS A 1 31  ? -54.268 22.382 -16.556 1.00 66.52  ? 31  LYS A NZ   1 
ATOM   478  H H    . LYS A 1 31  ? -53.156 19.893 -12.115 1.00 69.91  ? 31  LYS A H    1 
ATOM   479  H HA   . LYS A 1 31  ? -52.712 22.575 -11.832 1.00 69.50  ? 31  LYS A HA   1 
ATOM   480  H HB2  . LYS A 1 31  ? -55.342 21.535 -12.106 1.00 66.53  ? 31  LYS A HB2  1 
ATOM   481  H HB3  . LYS A 1 31  ? -55.027 23.008 -11.598 1.00 66.53  ? 31  LYS A HB3  1 
ATOM   482  H HG2  . LYS A 1 31  ? -53.878 23.471 -13.589 1.00 81.16  ? 31  LYS A HG2  1 
ATOM   483  H HG3  . LYS A 1 31  ? -54.122 21.983 -14.092 1.00 81.16  ? 31  LYS A HG3  1 
ATOM   484  H HD2  . LYS A 1 31  ? -56.523 22.915 -13.984 1.00 83.02  ? 31  LYS A HD2  1 
ATOM   485  H HD3  . LYS A 1 31  ? -55.689 24.172 -14.483 1.00 83.02  ? 31  LYS A HD3  1 
ATOM   486  H HE2  . LYS A 1 31  ? -56.157 21.761 -15.875 1.00 94.95  ? 31  LYS A HE2  1 
ATOM   487  H HE3  . LYS A 1 31  ? -56.186 23.238 -16.463 1.00 94.95  ? 31  LYS A HE3  1 
ATOM   488  H HZ1  . LYS A 1 31  ? -54.318 21.737 -17.167 1.00 79.87  ? 31  LYS A HZ1  1 
ATOM   489  H HZ2  . LYS A 1 31  ? -53.987 23.130 -16.949 1.00 79.87  ? 31  LYS A HZ2  1 
ATOM   490  H HZ3  . LYS A 1 31  ? -53.679 22.145 -15.933 1.00 79.87  ? 31  LYS A HZ3  1 
ATOM   491  N N    . SER A 1 32  ? -52.722 22.410 -9.454  1.00 53.03  ? 32  SER A N    1 
ATOM   492  C CA   . SER A 1 32  ? -52.573 22.115 -8.038  1.00 55.47  ? 32  SER A CA   1 
ATOM   493  C C    . SER A 1 32  ? -53.810 22.488 -7.233  1.00 49.16  ? 32  SER A C    1 
ATOM   494  O O    . SER A 1 32  ? -54.669 23.240 -7.700  1.00 47.96  ? 32  SER A O    1 
ATOM   495  C CB   . SER A 1 32  ? -51.307 22.790 -7.491  1.00 57.47  ? 32  SER A CB   1 
ATOM   496  O OG   . SER A 1 32  ? -51.044 24.029 -8.099  1.00 49.83  ? 32  SER A OG   1 
ATOM   497  H H    . SER A 1 32  ? -52.483 23.196 -9.710  1.00 63.68  ? 32  SER A H    1 
ATOM   498  H HA   . SER A 1 32  ? -52.467 21.158 -7.921  1.00 66.62  ? 32  SER A HA   1 
ATOM   499  H HB2  . SER A 1 32  ? -51.421 22.933 -6.539  1.00 69.02  ? 32  SER A HB2  1 
ATOM   500  H HB3  . SER A 1 32  ? -50.552 22.203 -7.651  1.00 69.02  ? 32  SER A HB3  1 
ATOM   501  H HG   . SER A 1 32  ? -50.215 24.136 -8.187  1.00 59.85  ? 32  SER A HG   1 
ATOM   502  N N    . PRO A 1 33  ? -53.958 21.947 -6.022  1.00 44.52  ? 33  PRO A N    1 
ATOM   503  C CA   . PRO A 1 33  ? -55.113 22.339 -5.212  1.00 46.15  ? 33  PRO A CA   1 
ATOM   504  C C    . PRO A 1 33  ? -55.014 23.808 -4.850  1.00 48.48  ? 33  PRO A C    1 
ATOM   505  O O    . PRO A 1 33  ? -53.917 24.364 -4.726  1.00 46.28  ? 33  PRO A O    1 
ATOM   506  C CB   . PRO A 1 33  ? -55.032 21.434 -3.971  1.00 47.84  ? 33  PRO A CB   1 
ATOM   507  C CG   . PRO A 1 33  ? -53.632 20.949 -3.910  1.00 49.69  ? 33  PRO A CG   1 
ATOM   508  C CD   . PRO A 1 33  ? -53.047 21.034 -5.309  1.00 42.04  ? 33  PRO A CD   1 
ATOM   509  H HA   . PRO A 1 33  ? -55.951 22.156 -5.666  1.00 55.43  ? 33  PRO A HA   1 
ATOM   510  H HB2  . PRO A 1 33  ? -55.252 21.947 -3.178  1.00 57.46  ? 33  PRO A HB2  1 
ATOM   511  H HB3  . PRO A 1 33  ? -55.648 20.692 -4.068  1.00 57.46  ? 33  PRO A HB3  1 
ATOM   512  H HG2  . PRO A 1 33  ? -53.126 21.509 -3.300  1.00 59.68  ? 33  PRO A HG2  1 
ATOM   513  H HG3  . PRO A 1 33  ? -53.626 20.030 -3.599  1.00 59.68  ? 33  PRO A HG3  1 
ATOM   514  H HD2  . PRO A 1 33  ? -52.148 21.398 -5.283  1.00 50.49  ? 33  PRO A HD2  1 
ATOM   515  H HD3  . PRO A 1 33  ? -53.039 20.160 -5.731  1.00 50.49  ? 33  PRO A HD3  1 
ATOM   516  N N    . LEU A 1 34  ? -56.175 24.431 -4.667  1.00 52.60  ? 34  LEU A N    1 
ATOM   517  C CA   . LEU A 1 34  ? -56.197 25.880 -4.469  1.00 48.52  ? 34  LEU A CA   1 
ATOM   518  C C    . LEU A 1 34  ? -55.796 26.202 -3.032  1.00 43.45  ? 34  LEU A C    1 
ATOM   519  O O    . LEU A 1 34  ? -56.183 25.476 -2.122  1.00 46.70  ? 34  LEU A O    1 
ATOM   520  C CB   . LEU A 1 34  ? -57.584 26.458 -4.723  1.00 52.98  ? 34  LEU A CB   1 
ATOM   521  C CG   . LEU A 1 34  ? -58.315 26.339 -6.063  1.00 61.46  ? 34  LEU A CG   1 
ATOM   522  C CD1  . LEU A 1 34  ? -58.938 24.841 -5.955  1.00 71.31  ? 34  LEU A CD1  1 
ATOM   523  C CD2  . LEU A 1 34  ? -59.276 27.363 -6.456  1.00 56.29  ? 34  LEU A CD2  1 
ATOM   524  H H    . LEU A 1 34  ? -56.946 24.049 -4.653  1.00 63.17  ? 34  LEU A H    1 
ATOM   525  H HA   . LEU A 1 34  ? -55.576 26.292 -5.090  1.00 58.28  ? 34  LEU A HA   1 
ATOM   526  H HB2  . LEU A 1 34  ? -58.174 26.047 -4.073  1.00 63.63  ? 34  LEU A HB2  1 
ATOM   527  H HB3  . LEU A 1 34  ? -57.517 27.411 -4.554  1.00 63.63  ? 34  LEU A HB3  1 
ATOM   528  H HG   . LEU A 1 34  ? -57.707 26.491 -6.803  1.00 73.80  ? 34  LEU A HG   1 
ATOM   529  H HD11 . LEU A 1 34  ? -59.491 24.673 -6.734  1.00 85.62  ? 34  LEU A HD11 1 
ATOM   530  H HD12 . LEU A 1 34  ? -58.211 24.199 -5.920  1.00 85.62  ? 34  LEU A HD12 1 
ATOM   531  H HD13 . LEU A 1 34  ? -59.473 24.779 -5.149  1.00 85.62  ? 34  LEU A HD13 1 
ATOM   532  H HD21 . LEU A 1 34  ? -59.623 27.148 -7.335  1.00 67.60  ? 34  LEU A HD21 1 
ATOM   533  H HD22 . LEU A 1 34  ? -59.999 27.382 -5.810  1.00 67.60  ? 34  LEU A HD22 1 
ATOM   534  H HD23 . LEU A 1 34  ? -58.828 28.223 -6.477  1.00 67.60  ? 34  LEU A HD23 1 
ATOM   535  N N    . PRO A 1 35  ? -55.084 27.295 -2.775  1.00 38.57  ? 35  PRO A N    1 
ATOM   536  C CA   . PRO A 1 35  ? -54.989 27.762 -1.384  1.00 40.32  ? 35  PRO A CA   1 
ATOM   537  C C    . PRO A 1 35  ? -56.373 28.117 -0.830  1.00 38.14  ? 35  PRO A C    1 
ATOM   538  O O    . PRO A 1 35  ? -57.281 28.501 -1.564  1.00 43.14  ? 35  PRO A O    1 
ATOM   539  C CB   . PRO A 1 35  ? -54.088 29.009 -1.471  1.00 41.58  ? 35  PRO A CB   1 
ATOM   540  C CG   . PRO A 1 35  ? -53.624 29.104 -2.906  1.00 48.44  ? 35  PRO A CG   1 
ATOM   541  C CD   . PRO A 1 35  ? -54.560 28.277 -3.739  1.00 46.63  ? 35  PRO A CD   1 
ATOM   542  H HA   . PRO A 1 35  ? -54.564 27.094 -0.824  1.00 48.44  ? 35  PRO A HA   1 
ATOM   543  H HB2  . PRO A 1 35  ? -54.599 29.796 -1.225  1.00 49.95  ? 35  PRO A HB2  1 
ATOM   544  H HB3  . PRO A 1 35  ? -53.331 28.905 -0.873  1.00 49.95  ? 35  PRO A HB3  1 
ATOM   545  H HG2  . PRO A 1 35  ? -53.648 30.031 -3.190  1.00 58.17  ? 35  PRO A HG2  1 
ATOM   546  H HG3  . PRO A 1 35  ? -52.719 28.760 -2.973  1.00 58.17  ? 35  PRO A HG3  1 
ATOM   547  H HD2  . PRO A 1 35  ? -55.276 28.823 -4.100  1.00 56.00  ? 35  PRO A HD2  1 
ATOM   548  H HD3  . PRO A 1 35  ? -54.084 27.835 -4.459  1.00 56.00  ? 35  PRO A HD3  1 
ATOM   549  N N    . SER A 1 36  ? -56.527 27.975 0.482   1.00 38.44  ? 36  SER A N    1 
ATOM   550  C CA   . SER A 1 36  ? -57.821 28.119 1.121   1.00 41.16  ? 36  SER A CA   1 
ATOM   551  C C    . SER A 1 36  ? -57.553 28.481 2.570   1.00 41.28  ? 36  SER A C    1 
ATOM   552  O O    . SER A 1 36  ? -56.470 28.214 3.101   1.00 35.69  ? 36  SER A O    1 
ATOM   553  C CB   . SER A 1 36  ? -58.627 26.827 1.059   1.00 39.45  ? 36  SER A CB   1 
ATOM   554  O OG   . SER A 1 36  ? -58.148 26.054 2.125   1.00 38.38  ? 36  SER A OG   1 
ATOM   555  H H    . SER A 1 36  ? -55.887 27.793 1.027   1.00 46.18  ? 36  SER A H    1 
ATOM   556  H HA   . SER A 1 36  ? -58.334 28.818 0.685   1.00 49.45  ? 36  SER A HA   1 
ATOM   557  H HB2  . SER A 1 36  ? -59.573 27.012 1.172   1.00 47.40  ? 36  SER A HB2  1 
ATOM   558  H HB3  . SER A 1 36  ? -58.476 26.373 0.216   1.00 47.40  ? 36  SER A HB3  1 
ATOM   559  H HG   . SER A 1 36  ? -58.351 25.247 2.009   1.00 46.11  ? 36  SER A HG   1 
ATOM   560  N N    . LEU A 1 37  ? -58.564 29.074 3.206   1.00 44.92  ? 37  LEU A N    1 
ATOM   561  C CA   . LEU A 1 37  ? -58.425 29.501 4.587   1.00 39.57  ? 37  LEU A CA   1 
ATOM   562  C C    . LEU A 1 37  ? -58.449 28.299 5.507   1.00 38.06  ? 37  LEU A C    1 
ATOM   563  O O    . LEU A 1 37  ? -57.741 28.263 6.528   1.00 39.67  ? 37  LEU A O    1 
ATOM   564  C CB   . LEU A 1 37  ? -59.547 30.508 4.899   1.00 41.67  ? 37  LEU A CB   1 
ATOM   565  C CG   . LEU A 1 37  ? -59.408 31.842 4.164   1.00 47.71  ? 37  LEU A CG   1 
ATOM   566  C CD1  . LEU A 1 37  ? -60.788 32.498 4.067   1.00 48.37  ? 37  LEU A CD1  1 
ATOM   567  C CD2  . LEU A 1 37  ? -58.386 32.743 4.851   1.00 45.16  ? 37  LEU A CD2  1 
ATOM   568  H H    . LEU A 1 37  ? -59.334 29.237 2.859   1.00 53.95  ? 37  LEU A H    1 
ATOM   569  H HA   . LEU A 1 37  ? -57.580 29.953 4.736   1.00 47.53  ? 37  LEU A HA   1 
ATOM   570  H HB2  . LEU A 1 37  ? -60.396 30.116 4.642   1.00 50.05  ? 37  LEU A HB2  1 
ATOM   571  H HB3  . LEU A 1 37  ? -59.542 30.693 5.851   1.00 50.05  ? 37  LEU A HB3  1 
ATOM   572  H HG   . LEU A 1 37  ? -59.073 31.699 3.264   1.00 57.30  ? 37  LEU A HG   1 
ATOM   573  H HD11 . LEU A 1 37  ? -60.687 33.395 3.710   1.00 58.09  ? 37  LEU A HD11 1 
ATOM   574  H HD12 . LEU A 1 37  ? -61.349 31.969 3.479   1.00 58.09  ? 37  LEU A HD12 1 
ATOM   575  H HD13 . LEU A 1 37  ? -61.182 32.537 4.953   1.00 58.09  ? 37  LEU A HD13 1 
ATOM   576  H HD21 . LEU A 1 37  ? -58.270 33.549 4.323   1.00 54.24  ? 37  LEU A HD21 1 
ATOM   577  H HD22 . LEU A 1 37  ? -58.712 32.972 5.736   1.00 54.24  ? 37  LEU A HD22 1 
ATOM   578  H HD23 . LEU A 1 37  ? -57.543 32.269 4.921   1.00 54.24  ? 37  LEU A HD23 1 
ATOM   579  N N    . GLU A 1 38  ? -59.204 27.268 5.110   1.00 37.59  ? 38  GLU A N    1 
ATOM   580  C CA   . GLU A 1 38  ? -59.165 26.001 5.841   1.00 45.66  ? 38  GLU A CA   1 
ATOM   581  C C    . GLU A 1 38  ? -57.733 25.448 5.924   1.00 44.88  ? 38  GLU A C    1 
ATOM   582  O O    . GLU A 1 38  ? -57.375 24.742 6.882   1.00 41.81  ? 38  GLU A O    1 
ATOM   583  C CB   . GLU A 1 38  ? -60.029 24.916 5.209   1.00 50.68  ? 38  GLU A CB   1 
ATOM   584  C CG   . GLU A 1 38  ? -59.845 23.603 6.149   1.00 69.54  ? 38  GLU A CG   1 
ATOM   585  C CD   . GLU A 1 38  ? -60.817 22.435 5.861   1.00 79.67  ? 38  GLU A CD   1 
ATOM   586  O OE1  . GLU A 1 38  ? -61.809 22.473 5.057   1.00 106.67 ? 38  GLU A OE1  1 
ATOM   587  O OE2  . GLU A 1 38  ? -60.692 21.533 6.633   1.00 76.25  ? 38  GLU A OE2  1 
ATOM   588  H H    . GLU A 1 38  ? -59.735 27.278 4.434   1.00 45.16  ? 38  GLU A H    1 
ATOM   589  H HA   . GLU A 1 38  ? -59.524 26.193 6.722   1.00 54.85  ? 38  GLU A HA   1 
ATOM   590  H HB2  . GLU A 1 38  ? -60.961 25.185 5.197   1.00 60.87  ? 38  GLU A HB2  1 
ATOM   591  H HB3  . GLU A 1 38  ? -59.728 24.721 4.308   1.00 60.87  ? 38  GLU A HB3  1 
ATOM   592  H HG2  . GLU A 1 38  ? -58.944 23.265 6.028   1.00 83.50  ? 38  GLU A HG2  1 
ATOM   593  H HG3  . GLU A 1 38  ? -59.979 23.868 7.073   1.00 83.50  ? 38  GLU A HG3  1 
ATOM   594  N N    . TYR A 1 39  ? -56.899 25.714 4.917   1.00 46.06  ? 39  TYR A N    1 
ATOM   595  C CA   . TYR A 1 39  ? -55.519 25.264 4.969   1.00 44.92  ? 39  TYR A CA   1 
ATOM   596  C C    . TYR A 1 39  ? -54.590 26.354 5.457   1.00 44.13  ? 39  TYR A C    1 
ATOM   597  O O    . TYR A 1 39  ? -53.380 26.311 5.196   1.00 42.80  ? 39  TYR A O    1 
ATOM   598  C CB   . TYR A 1 39  ? -55.109 24.739 3.605   1.00 43.66  ? 39  TYR A CB   1 
ATOM   599  C CG   . TYR A 1 39  ? -55.381 23.250 3.423   1.00 48.63  ? 39  TYR A CG   1 
ATOM   600  C CD1  . TYR A 1 39  ? -56.642 22.787 3.056   1.00 48.05  ? 39  TYR A CD1  1 
ATOM   601  C CD2  . TYR A 1 39  ? -54.364 22.306 3.604   1.00 37.06  ? 39  TYR A CD2  1 
ATOM   602  C CE1  . TYR A 1 39  ? -56.877 21.417 2.869   1.00 50.15  ? 39  TYR A CE1  1 
ATOM   603  C CE2  . TYR A 1 39  ? -54.591 20.965 3.405   1.00 45.13  ? 39  TYR A CE2  1 
ATOM   604  C CZ   . TYR A 1 39  ? -55.845 20.514 3.050   1.00 48.12  ? 39  TYR A CZ   1 
ATOM   605  O OH   . TYR A 1 39  ? -56.064 19.160 2.869   1.00 46.92  ? 39  TYR A OH   1 
ATOM   606  H H    . TYR A 1 39  ? -57.113 26.148 4.205   1.00 55.33  ? 39  TYR A H    1 
ATOM   607  H HA   . TYR A 1 39  ? -55.436 24.527 5.594   1.00 53.96  ? 39  TYR A HA   1 
ATOM   608  H HB2  . TYR A 1 39  ? -55.605 25.218 2.923   1.00 52.44  ? 39  TYR A HB2  1 
ATOM   609  H HB3  . TYR A 1 39  ? -54.157 24.885 3.487   1.00 52.44  ? 39  TYR A HB3  1 
ATOM   610  H HD1  . TYR A 1 39  ? -57.336 23.393 2.933   1.00 57.72  ? 39  TYR A HD1  1 
ATOM   611  H HD2  . TYR A 1 39  ? -53.518 22.592 3.865   1.00 44.53  ? 39  TYR A HD2  1 
ATOM   612  H HE1  . TYR A 1 39  ? -57.723 21.116 2.624   1.00 60.23  ? 39  TYR A HE1  1 
ATOM   613  H HE2  . TYR A 1 39  ? -53.894 20.357 3.510   1.00 54.21  ? 39  TYR A HE2  1 
ATOM   614  H HH   . TYR A 1 39  ? -55.334 18.746 2.883   1.00 56.36  ? 39  TYR A HH   1 
ATOM   615  N N    . GLY A 1 40  ? -55.120 27.315 6.211   1.00 40.98  ? 40  GLY A N    1 
ATOM   616  C CA   . GLY A 1 40  ? -54.249 28.252 6.896   1.00 41.05  ? 40  GLY A CA   1 
ATOM   617  C C    . GLY A 1 40  ? -53.778 29.425 6.069   1.00 37.52  ? 40  GLY A C    1 
ATOM   618  O O    . GLY A 1 40  ? -52.954 30.210 6.548   1.00 45.36  ? 40  GLY A O    1 
ATOM   619  H H    . GLY A 1 40  ? -55.962 27.438 6.336   1.00 49.23  ? 40  GLY A H    1 
ATOM   620  H HA2  . GLY A 1 40  ? -54.721 28.606 7.665   1.00 49.31  ? 40  GLY A HA2  1 
ATOM   621  H HA3  . GLY A 1 40  ? -53.462 27.774 7.201   1.00 49.31  ? 40  GLY A HA3  1 
ATOM   622  N N    . ALA A 1 41  ? -54.322 29.608 4.875   1.00 42.17  ? 41  ALA A N    1 
ATOM   623  C CA   . ALA A 1 41  ? -54.011 30.782 4.074   1.00 38.72  ? 41  ALA A CA   1 
ATOM   624  C C    . ALA A 1 41  ? -54.379 32.077 4.796   1.00 43.22  ? 41  ALA A C    1 
ATOM   625  O O    . ALA A 1 41  ? -55.516 32.270 5.237   1.00 44.03  ? 41  ALA A O    1 
ATOM   626  C CB   . ALA A 1 41  ? -54.747 30.706 2.740   1.00 34.49  ? 41  ALA A CB   1 
ATOM   627  H H    . ALA A 1 41  ? -54.877 29.066 4.504   1.00 50.66  ? 41  ALA A H    1 
ATOM   628  H HA   . ALA A 1 41  ? -53.055 30.798 3.913   1.00 46.51  ? 41  ALA A HA   1 
ATOM   629  H HB1  . ALA A 1 41  ? -55.698 30.613 2.909   1.00 41.44  ? 41  ALA A HB1  1 
ATOM   630  H HB2  . ALA A 1 41  ? -54.422 29.938 2.244   1.00 41.44  ? 41  ALA A HB2  1 
ATOM   631  H HB3  . ALA A 1 41  ? -54.578 31.519 2.239   1.00 41.44  ? 41  ALA A HB3  1 
ATOM   632  N N    . ASN A 1 42  ? -53.409 32.982 4.889   1.00 42.47  ? 42  ASN A N    1 
ATOM   633  C CA   . ASN A 1 42  ? -53.562 34.263 5.582   1.00 41.28  ? 42  ASN A CA   1 
ATOM   634  C C    . ASN A 1 42  ? -52.966 35.339 4.677   1.00 39.30  ? 42  ASN A C    1 
ATOM   635  O O    . ASN A 1 42  ? -51.748 35.565 4.660   1.00 31.66  ? 42  ASN A O    1 
ATOM   636  C CB   . ASN A 1 42  ? -52.876 34.231 6.945   1.00 40.09  ? 42  ASN A CB   1 
ATOM   637  C CG   . ASN A 1 42  ? -53.064 35.522 7.715   1.00 43.00  ? 42  ASN A CG   1 
ATOM   638  O OD1  . ASN A 1 42  ? -53.328 36.578 7.124   1.00 40.66  ? 42  ASN A OD1  1 
ATOM   639  N ND2  . ASN A 1 42  ? -52.920 35.454 9.030   1.00 48.01  ? 42  ASN A ND2  1 
ATOM   640  H H    . ASN A 1 42  ? -52.627 32.876 4.547   1.00 51.01  ? 42  ASN A H    1 
ATOM   641  H HA   . ASN A 1 42  ? -54.502 34.457 5.718   1.00 49.58  ? 42  ASN A HA   1 
ATOM   642  H HB2  . ASN A 1 42  ? -53.251 33.508 7.472   1.00 48.16  ? 42  ASN A HB2  1 
ATOM   643  H HB3  . ASN A 1 42  ? -51.925 34.091 6.819   1.00 48.16  ? 42  ASN A HB3  1 
ATOM   644  H HD21 . ASN A 1 42  ? -52.729 34.703 9.403   1.00 57.66  ? 42  ASN A HD21 1 
ATOM   645  H HD22 . ASN A 1 42  ? -53.017 36.160 9.511   1.00 57.66  ? 42  ASN A HD22 1 
ATOM   646  N N    . TYR A 1 43  ? -53.829 36.013 3.935   1.00 37.67  ? 43  TYR A N    1 
ATOM   647  C CA   . TYR A 1 43  ? -53.321 36.899 2.908   1.00 43.54  ? 43  TYR A CA   1 
ATOM   648  C C    . TYR A 1 43  ? -52.617 38.108 3.497   1.00 39.30  ? 43  TYR A C    1 
ATOM   649  O O    . TYR A 1 43  ? -51.628 38.573 2.937   1.00 34.60  ? 43  TYR A O    1 
ATOM   650  C CB   . TYR A 1 43  ? -54.463 37.235 1.965   1.00 45.13  ? 43  TYR A CB   1 
ATOM   651  C CG   . TYR A 1 43  ? -54.625 36.112 0.881   1.00 61.21  ? 43  TYR A CG   1 
ATOM   652  C CD1  . TYR A 1 43  ? -55.282 34.887 1.145   1.00 58.64  ? 43  TYR A CD1  1 
ATOM   653  C CD2  . TYR A 1 43  ? -54.092 36.280 -0.401  1.00 62.24  ? 43  TYR A CD2  1 
ATOM   654  C CE1  . TYR A 1 43  ? -55.417 33.898 0.131   1.00 60.93  ? 43  TYR A CE1  1 
ATOM   655  C CE2  . TYR A 1 43  ? -54.226 35.309 -1.401  1.00 53.26  ? 43  TYR A CE2  1 
ATOM   656  C CZ   . TYR A 1 43  ? -54.874 34.134 -1.142  1.00 60.01  ? 43  TYR A CZ   1 
ATOM   657  O OH   . TYR A 1 43  ? -54.959 33.223 -2.174  1.00 62.16  ? 43  TYR A OH   1 
ATOM   658  H H    . TYR A 1 43  ? -54.685 35.976 4.004   1.00 45.26  ? 43  TYR A H    1 
ATOM   659  H HA   . TYR A 1 43  ? -52.639 36.466 2.372   1.00 52.30  ? 43  TYR A HA   1 
ATOM   660  H HB2  . TYR A 1 43  ? -55.290 37.302 2.467   1.00 54.21  ? 43  TYR A HB2  1 
ATOM   661  H HB3  . TYR A 1 43  ? -54.277 38.074 1.517   1.00 54.21  ? 43  TYR A HB3  1 
ATOM   662  H HD1  . TYR A 1 43  ? -55.629 34.726 1.993   1.00 70.42  ? 43  TYR A HD1  1 
ATOM   663  H HD2  . TYR A 1 43  ? -53.632 37.065 -0.596  1.00 74.73  ? 43  TYR A HD2  1 
ATOM   664  H HE1  . TYR A 1 43  ? -55.862 33.102 0.310   1.00 73.17  ? 43  TYR A HE1  1 
ATOM   665  H HE2  . TYR A 1 43  ? -53.872 35.465 -2.246  1.00 63.97  ? 43  TYR A HE2  1 
ATOM   666  H HH   . TYR A 1 43  ? -54.673 33.567 -2.885  1.00 74.64  ? 43  TYR A HH   1 
ATOM   667  N N    . PHE A 1 44  ? -53.012 38.560 4.669   1.00 35.86  ? 44  PHE A N    1 
ATOM   668  C CA   . PHE A 1 44  ? -52.304 39.689 5.250   1.00 38.34  ? 44  PHE A CA   1 
ATOM   669  C C    . PHE A 1 44  ? -50.905 39.309 5.725   1.00 41.40  ? 44  PHE A C    1 
ATOM   670  O O    . PHE A 1 44  ? -49.990 40.128 5.653   1.00 35.65  ? 44  PHE A O    1 
ATOM   671  C CB   . PHE A 1 44  ? -53.131 40.258 6.378   1.00 38.57  ? 44  PHE A CB   1 
ATOM   672  C CG   . PHE A 1 44  ? -54.544 40.516 5.954   1.00 37.65  ? 44  PHE A CG   1 
ATOM   673  C CD1  . PHE A 1 44  ? -55.496 39.483 5.978   1.00 52.60  ? 44  PHE A CD1  1 
ATOM   674  C CD2  . PHE A 1 44  ? -54.910 41.743 5.434   1.00 42.45  ? 44  PHE A CD2  1 
ATOM   675  C CE1  . PHE A 1 44  ? -56.823 39.711 5.535   1.00 54.73  ? 44  PHE A CE1  1 
ATOM   676  C CE2  . PHE A 1 44  ? -56.222 41.971 5.000   1.00 43.15  ? 44  PHE A CE2  1 
ATOM   677  C CZ   . PHE A 1 44  ? -57.176 40.956 5.066   1.00 53.61  ? 44  PHE A CZ   1 
ATOM   678  H H    . PHE A 1 44  ? -53.663 38.246 5.135   1.00 43.08  ? 44  PHE A H    1 
ATOM   679  H HA   . PHE A 1 44  ? -52.188 40.379 4.579   1.00 46.06  ? 44  PHE A HA   1 
ATOM   680  H HB2  . PHE A 1 44  ? -53.144 39.628 7.115   1.00 46.33  ? 44  PHE A HB2  1 
ATOM   681  H HB3  . PHE A 1 44  ? -52.742 41.098 6.668   1.00 46.33  ? 44  PHE A HB3  1 
ATOM   682  H HD1  . PHE A 1 44  ? -55.254 38.641 6.289   1.00 63.17  ? 44  PHE A HD1  1 
ATOM   683  H HD2  . PHE A 1 44  ? -54.280 42.424 5.372   1.00 50.99  ? 44  PHE A HD2  1 
ATOM   684  H HE1  . PHE A 1 44  ? -57.450 39.025 5.561   1.00 65.72  ? 44  PHE A HE1  1 
ATOM   685  H HE2  . PHE A 1 44  ? -56.459 42.806 4.666   1.00 51.84  ? 44  PHE A HE2  1 
ATOM   686  H HZ   . PHE A 1 44  ? -58.049 41.120 4.793   1.00 64.38  ? 44  PHE A HZ   1 
ATOM   687  N N    . LEU A 1 45  ? -50.711 38.091 6.215   1.00 39.23  ? 45  LEU A N    1 
ATOM   688  C CA   . LEU A 1 45  ? -49.390 37.686 6.665   1.00 38.13  ? 45  LEU A CA   1 
ATOM   689  C C    . LEU A 1 45  ? -48.567 37.106 5.534   1.00 35.32  ? 45  LEU A C    1 
ATOM   690  O O    . LEU A 1 45  ? -47.383 37.401 5.420   1.00 38.37  ? 45  LEU A O    1 
ATOM   691  C CB   . LEU A 1 45  ? -49.533 36.649 7.783   1.00 38.26  ? 45  LEU A CB   1 
ATOM   692  C CG   . LEU A 1 45  ? -48.382 35.717 8.095   1.00 40.12  ? 45  LEU A CG   1 
ATOM   693  C CD1  . LEU A 1 45  ? -47.280 36.486 8.730   1.00 40.09  ? 45  LEU A CD1  1 
ATOM   694  C CD2  . LEU A 1 45  ? -48.858 34.551 8.988   1.00 38.10  ? 45  LEU A CD2  1 
ATOM   695  H H    . LEU A 1 45  ? -51.320 37.490 6.295   1.00 47.13  ? 45  LEU A H    1 
ATOM   696  H HA   . LEU A 1 45  ? -48.917 38.455 7.020   1.00 45.80  ? 45  LEU A HA   1 
ATOM   697  H HB2  . LEU A 1 45  ? -49.718 37.134 8.603   1.00 45.96  ? 45  LEU A HB2  1 
ATOM   698  H HB3  . LEU A 1 45  ? -50.286 36.082 7.555   1.00 45.96  ? 45  LEU A HB3  1 
ATOM   699  H HG   . LEU A 1 45  ? -48.038 35.323 7.278   1.00 48.20  ? 45  LEU A HG   1 
ATOM   700  H HD11 . LEU A 1 45  ? -46.857 37.045 8.059   1.00 48.16  ? 45  LEU A HD11 1 
ATOM   701  H HD12 . LEU A 1 45  ? -46.633 35.865 9.100   1.00 48.16  ? 45  LEU A HD12 1 
ATOM   702  H HD13 . LEU A 1 45  ? -47.648 37.040 9.437   1.00 48.16  ? 45  LEU A HD13 1 
ATOM   703  H HD21 . LEU A 1 45  ? -49.288 34.913 9.779   1.00 45.77  ? 45  LEU A HD21 1 
ATOM   704  H HD22 . LEU A 1 45  ? -48.090 34.016 9.245   1.00 45.77  ? 45  LEU A HD22 1 
ATOM   705  H HD23 . LEU A 1 45  ? -49.487 34.007 8.489   1.00 45.77  ? 45  LEU A HD23 1 
ATOM   706  N N    . GLN A 1 46  ? -49.163 36.267 4.703   1.00 34.69  ? 46  GLN A N    1 
ATOM   707  C CA   . GLN A 1 46  ? -48.387 35.508 3.741   1.00 38.55  ? 46  GLN A CA   1 
ATOM   708  C C    . GLN A 1 46  ? -48.182 36.239 2.426   1.00 28.49  ? 46  GLN A C    1 
ATOM   709  O O    . GLN A 1 46  ? -47.215 35.935 1.717   1.00 27.64  ? 46  GLN A O    1 
ATOM   710  C CB   . GLN A 1 46  ? -49.079 34.150 3.483   1.00 32.06  ? 46  GLN A CB   1 
ATOM   711  C CG   . GLN A 1 46  ? -49.156 33.292 4.749   1.00 36.96  ? 46  GLN A CG   1 
ATOM   712  C CD   . GLN A 1 46  ? -50.136 32.171 4.656   1.00 37.39  ? 46  GLN A CD   1 
ATOM   713  O OE1  . GLN A 1 46  ? -50.940 32.098 3.726   1.00 34.62  ? 46  GLN A OE1  1 
ATOM   714  N NE2  . GLN A 1 46  ? -50.056 31.250 5.617   1.00 44.68  ? 46  GLN A NE2  1 
ATOM   715  H H    . GLN A 1 46  ? -50.010 36.122 4.676   1.00 41.68  ? 46  GLN A H    1 
ATOM   716  H HA   . GLN A 1 46  ? -47.507 35.332 4.108   1.00 46.31  ? 46  GLN A HA   1 
ATOM   717  H HB2  . GLN A 1 46  ? -49.982 34.308 3.168   1.00 38.52  ? 46  GLN A HB2  1 
ATOM   718  H HB3  . GLN A 1 46  ? -48.576 33.659 2.814   1.00 38.52  ? 46  GLN A HB3  1 
ATOM   719  H HG2  . GLN A 1 46  ? -48.282 32.907 4.920   1.00 44.41  ? 46  GLN A HG2  1 
ATOM   720  H HG3  . GLN A 1 46  ? -49.421 33.856 5.493   1.00 44.41  ? 46  GLN A HG3  1 
ATOM   721  H HE21 . GLN A 1 46  ? -49.466 31.325 6.237   1.00 53.67  ? 46  GLN A HE21 1 
ATOM   722  H HE22 . GLN A 1 46  ? -50.596 30.580 5.616   1.00 53.67  ? 46  GLN A HE22 1 
ATOM   723  N N    . ILE A 1 47  ? -49.026 37.208 2.103   1.00 29.66  ? 47  ILE A N    1 
ATOM   724  C CA   . ILE A 1 47  ? -49.143 37.642 0.717   1.00 38.99  ? 47  ILE A CA   1 
ATOM   725  C C    . ILE A 1 47  ? -49.005 39.152 0.537   1.00 39.41  ? 47  ILE A C    1 
ATOM   726  O O    . ILE A 1 47  ? -48.524 39.625 -0.513  1.00 30.47  ? 47  ILE A O    1 
ATOM   727  C CB   . ILE A 1 47  ? -50.483 37.171 0.123   1.00 32.13  ? 47  ILE A CB   1 
ATOM   728  C CG1  . ILE A 1 47  ? -50.487 35.678 -0.201  1.00 36.92  ? 47  ILE A CG1  1 
ATOM   729  C CG2  . ILE A 1 47  ? -50.871 37.954 -1.168  1.00 37.96  ? 47  ILE A CG2  1 
ATOM   730  C CD1  . ILE A 1 47  ? -49.675 35.332 -1.458  1.00 35.67  ? 47  ILE A CD1  1 
ATOM   731  H H    . ILE A 1 47  ? -49.535 37.623 2.658   1.00 35.64  ? 47  ILE A H    1 
ATOM   732  H HA   . ILE A 1 47  ? -48.389 37.251 0.248   1.00 46.84  ? 47  ILE A HA   1 
ATOM   733  H HB   . ILE A 1 47  ? -51.136 37.350 0.817   1.00 38.60  ? 47  ILE A HB   1 
ATOM   734  H HG12 . ILE A 1 47  ? -50.101 35.193 0.546   1.00 44.36  ? 47  ILE A HG12 1 
ATOM   735  H HG13 . ILE A 1 47  ? -51.401 35.390 -0.346  1.00 44.36  ? 47  ILE A HG13 1 
ATOM   736  H HG21 . ILE A 1 47  ? -51.282 38.795 -0.916  1.00 45.60  ? 47  ILE A HG21 1 
ATOM   737  H HG22 . ILE A 1 47  ? -51.497 37.422 -1.684  1.00 45.60  ? 47  ILE A HG22 1 
ATOM   738  H HG23 . ILE A 1 47  ? -50.070 38.120 -1.690  1.00 45.60  ? 47  ILE A HG23 1 
ATOM   739  H HD11 . ILE A 1 47  ? -50.181 35.597 -2.243  1.00 42.85  ? 47  ILE A HD11 1 
ATOM   740  H HD12 . ILE A 1 47  ? -48.832 35.810 -1.431  1.00 42.85  ? 47  ILE A HD12 1 
ATOM   741  H HD13 . ILE A 1 47  ? -49.513 34.376 -1.477  1.00 42.85  ? 47  ILE A HD13 1 
ATOM   742  N N    . SER A 1 48  ? -49.358 39.933 1.550   1.00 33.30  ? 48  SER A N    1 
ATOM   743  C CA   . SER A 1 48  ? -49.559 41.339 1.225   1.00 38.42  ? 48  SER A CA   1 
ATOM   744  C C    . SER A 1 48  ? -48.239 42.074 1.014   1.00 37.15  ? 48  SER A C    1 
ATOM   745  O O    . SER A 1 48  ? -48.138 42.936 0.135   1.00 33.25  ? 48  SER A O    1 
ATOM   746  C CB   . SER A 1 48  ? -50.413 42.019 2.282   1.00 37.01  ? 48  SER A CB   1 
ATOM   747  O OG   . SER A 1 48  ? -49.691 42.378 3.415   1.00 44.55  ? 48  SER A OG   1 
ATOM   748  H H    . SER A 1 48  ? -49.478 39.694 2.367   1.00 40.01  ? 48  SER A H    1 
ATOM   749  H HA   . SER A 1 48  ? -50.051 41.391 0.391   1.00 46.15  ? 48  SER A HA   1 
ATOM   750  H HB2  . SER A 1 48  ? -50.797 42.822 1.896   1.00 44.46  ? 48  SER A HB2  1 
ATOM   751  H HB3  . SER A 1 48  ? -51.117 41.408 2.548   1.00 44.46  ? 48  SER A HB3  1 
ATOM   752  H HG   . SER A 1 48  ? -49.542 41.699 3.887   1.00 53.51  ? 48  SER A HG   1 
ATOM   753  N N    . ARG A 1 49  ? -47.219 41.779 1.794   1.00 35.68  ? 49  ARG A N    1 
ATOM   754  C CA   . ARG A 1 49  ? -45.917 42.347 1.472   1.00 36.25  ? 49  ARG A CA   1 
ATOM   755  C C    . ARG A 1 49  ? -45.356 41.786 0.168   1.00 36.94  ? 49  ARG A C    1 
ATOM   756  O O    . ARG A 1 49  ? -44.636 42.489 -0.549  1.00 35.08  ? 49  ARG A O    1 
ATOM   757  C CB   . ARG A 1 49  ? -44.960 42.100 2.619   1.00 37.99  ? 49  ARG A CB   1 
ATOM   758  C CG   . ARG A 1 49  ? -45.212 43.018 3.801   1.00 42.70  ? 49  ARG A CG   1 
ATOM   759  C CD   . ARG A 1 49  ? -45.032 44.555 3.452   1.00 38.18  ? 49  ARG A CD   1 
ATOM   760  N NE   . ARG A 1 49  ? -45.198 45.360 4.668   1.00 41.11  ? 49  ARG A NE   1 
ATOM   761  C CZ   . ARG A 1 49  ? -45.687 46.596 4.710   1.00 36.22  ? 49  ARG A CZ   1 
ATOM   762  N NH1  . ARG A 1 49  ? -46.069 47.179 3.594   1.00 37.39  ? 49  ARG A NH1  1 
ATOM   763  N NH2  . ARG A 1 49  ? -45.789 47.224 5.866   1.00 36.11  ? 49  ARG A NH2  1 
ATOM   764  H H    . ARG A 1 49  ? -47.246 41.272 2.488   1.00 42.87  ? 49  ARG A H    1 
ATOM   765  H HA   . ARG A 1 49  ? -46.011 43.305 1.356   1.00 43.55  ? 49  ARG A HA   1 
ATOM   766  H HB2  . ARG A 1 49  ? -45.061 41.185 2.922   1.00 45.63  ? 49  ARG A HB2  1 
ATOM   767  H HB3  . ARG A 1 49  ? -44.053 42.250 2.310   1.00 45.63  ? 49  ARG A HB3  1 
ATOM   768  H HG2  . ARG A 1 49  ? -46.122 42.888 4.111   1.00 51.29  ? 49  ARG A HG2  1 
ATOM   769  H HG3  . ARG A 1 49  ? -44.586 42.798 4.509   1.00 51.29  ? 49  ARG A HG3  1 
ATOM   770  H HD2  . ARG A 1 49  ? -44.143 44.708 3.095   1.00 45.87  ? 49  ARG A HD2  1 
ATOM   771  H HD3  . ARG A 1 49  ? -45.701 44.825 2.804   1.00 45.87  ? 49  ARG A HD3  1 
ATOM   772  H HE   . ARG A 1 49  ? -44.961 45.003 5.413   1.00 49.39  ? 49  ARG A HE   1 
ATOM   773  H HH11 . ARG A 1 49  ? -46.002 46.760 2.845   1.00 44.92  ? 49  ARG A HH11 1 
ATOM   774  H HH12 . ARG A 1 49  ? -46.386 47.978 3.612   1.00 44.92  ? 49  ARG A HH12 1 
ATOM   775  H HH21 . ARG A 1 49  ? -45.541 46.834 6.591   1.00 43.39  ? 49  ARG A HH21 1 
ATOM   776  H HH22 . ARG A 1 49  ? -46.105 48.024 5.895   1.00 43.39  ? 49  ARG A HH22 1 
ATOM   777  N N    . VAL A 1 50  ? -45.703 40.554 -0.192  1.00 33.60  ? 50  VAL A N    1 
ATOM   778  C CA   . VAL A 1 50  ? -45.251 40.043 -1.475  1.00 38.53  ? 50  VAL A CA   1 
ATOM   779  C C    . VAL A 1 50  ? -45.878 40.830 -2.615  1.00 40.40  ? 50  VAL A C    1 
ATOM   780  O O    . VAL A 1 50  ? -45.253 41.023 -3.669  1.00 37.96  ? 50  VAL A O    1 
ATOM   781  C CB   . VAL A 1 50  ? -45.556 38.535 -1.580  1.00 34.87  ? 50  VAL A CB   1 
ATOM   782  C CG1  . VAL A 1 50  ? -45.265 38.030 -2.954  1.00 40.17  ? 50  VAL A CG1  1 
ATOM   783  C CG2  . VAL A 1 50  ? -44.695 37.751 -0.579  1.00 39.18  ? 50  VAL A CG2  1 
ATOM   784  H H    . VAL A 1 50  ? -46.183 40.014 0.274   1.00 40.36  ? 50  VAL A H    1 
ATOM   785  H HA   . VAL A 1 50  ? -44.289 40.159 -1.534  1.00 46.29  ? 50  VAL A HA   1 
ATOM   786  H HB   . VAL A 1 50  ? -46.497 38.402 -1.383  1.00 41.89  ? 50  VAL A HB   1 
ATOM   787  H HG11 . VAL A 1 50  ? -44.672 37.265 -2.890  1.00 48.25  ? 50  VAL A HG11 1 
ATOM   788  H HG12 . VAL A 1 50  ? -44.841 38.735 -3.466  1.00 48.25  ? 50  VAL A HG12 1 
ATOM   789  H HG13 . VAL A 1 50  ? -46.098 37.768 -3.377  1.00 48.25  ? 50  VAL A HG13 1 
ATOM   790  H HG21 . VAL A 1 50  ? -43.788 38.092 -0.608  1.00 47.07  ? 50  VAL A HG21 1 
ATOM   791  H HG22 . VAL A 1 50  ? -45.063 37.865 0.311   1.00 47.07  ? 50  VAL A HG22 1 
ATOM   792  H HG23 . VAL A 1 50  ? -44.704 36.812 -0.824  1.00 47.07  ? 50  VAL A HG23 1 
ATOM   793  N N    . ASN A 1 51  ? -47.132 41.247 -2.443  1.00 35.50  ? 51  ASN A N    1 
ATOM   794  C CA   . ASN A 1 51  ? -47.799 42.023 -3.469  1.00 33.88  ? 51  ASN A CA   1 
ATOM   795  C C    . ASN A 1 51  ? -47.167 43.406 -3.606  1.00 37.65  ? 51  ASN A C    1 
ATOM   796  O O    . ASN A 1 51  ? -46.964 43.883 -4.725  1.00 33.72  ? 51  ASN A O    1 
ATOM   797  C CB   . ASN A 1 51  ? -49.294 42.094 -3.133  1.00 34.10  ? 51  ASN A CB   1 
ATOM   798  C CG   . ASN A 1 51  ? -50.079 43.018 -4.068  1.00 39.20  ? 51  ASN A CG   1 
ATOM   799  O OD1  . ASN A 1 51  ? -50.200 42.758 -5.274  1.00 43.04  ? 51  ASN A OD1  1 
ATOM   800  N ND2  . ASN A 1 51  ? -50.652 44.089 -3.502  1.00 38.89  ? 51  ASN A ND2  1 
ATOM   801  H H    . ASN A 1 51  ? -47.610 41.092 -1.745  1.00 42.65  ? 51  ASN A H    1 
ATOM   802  H HA   . ASN A 1 51  ? -47.710 41.593 -4.334  1.00 40.70  ? 51  ASN A HA   1 
ATOM   803  H HB2  . ASN A 1 51  ? -49.675 41.204 -3.205  1.00 40.97  ? 51  ASN A HB2  1 
ATOM   804  H HB3  . ASN A 1 51  ? -49.398 42.427 -2.228  1.00 40.97  ? 51  ASN A HB3  1 
ATOM   805  H HD21 . ASN A 1 51  ? -50.568 44.226 -2.657  1.00 46.72  ? 51  ASN A HD21 1 
ATOM   806  H HD22 . ASN A 1 51  ? -51.105 44.640 -3.983  1.00 46.72  ? 51  ASN A HD22 1 
ATOM   807  N N    . ASP A 1 52  ? -46.788 44.024 -2.493  1.00 32.92  ? 52  ASP A N    1 
ATOM   808  C CA   . ASP A 1 52  ? -46.060 45.278 -2.533  1.00 39.23  ? 52  ASP A CA   1 
ATOM   809  C C    . ASP A 1 52  ? -44.764 45.147 -3.326  1.00 41.05  ? 52  ASP A C    1 
ATOM   810  O O    . ASP A 1 52  ? -44.422 46.031 -4.112  1.00 32.27  ? 52  ASP A O    1 
ATOM   811  C CB   . ASP A 1 52  ? -45.748 45.738 -1.106  1.00 36.16  ? 52  ASP A CB   1 
ATOM   812  C CG   . ASP A 1 52  ? -47.001 46.114 -0.299  1.00 43.24  ? 52  ASP A CG   1 
ATOM   813  O OD1  . ASP A 1 52  ? -48.000 46.510 -0.911  1.00 44.66  ? 52  ASP A OD1  1 
ATOM   814  O OD2  . ASP A 1 52  ? -46.976 46.066 0.971   1.00 38.97  ? 52  ASP A OD2  1 
ATOM   815  H H    . ASP A 1 52  ? -46.942 43.734 -1.698  1.00 39.55  ? 52  ASP A H    1 
ATOM   816  H HA   . ASP A 1 52  ? -46.617 45.943 -2.967  1.00 47.13  ? 52  ASP A HA   1 
ATOM   817  H HB2  . ASP A 1 52  ? -45.296 45.019 -0.636  1.00 43.44  ? 52  ASP A HB2  1 
ATOM   818  H HB3  . ASP A 1 52  ? -45.174 46.519 -1.146  1.00 43.44  ? 52  ASP A HB3  1 
ATOM   819  N N    . LEU A 1 53  ? -43.980 44.076 -3.089  1.00 40.20  ? 53  LEU A N    1 
ATOM   820  C CA   . LEU A 1 53  ? -42.676 43.989 -3.755  1.00 35.19  ? 53  LEU A CA   1 
ATOM   821  C C    . LEU A 1 53  ? -42.784 43.542 -5.223  1.00 38.46  ? 53  LEU A C    1 
ATOM   822  O O    . LEU A 1 53  ? -42.002 43.995 -6.072  1.00 33.01  ? 53  LEU A O    1 
ATOM   823  C CB   . LEU A 1 53  ? -41.760 43.059 -2.973  1.00 31.10  ? 53  LEU A CB   1 
ATOM   824  C CG   . LEU A 1 53  ? -41.446 43.481 -1.519  1.00 33.88  ? 53  LEU A CG   1 
ATOM   825  C CD1  . LEU A 1 53  ? -40.969 42.259 -0.685  1.00 37.17  ? 53  LEU A CD1  1 
ATOM   826  C CD2  . LEU A 1 53  ? -40.392 44.595 -1.440  1.00 35.86  ? 53  LEU A CD2  1 
ATOM   827  H H    . LEU A 1 53  ? -44.175 43.419 -2.569  1.00 48.29  ? 53  LEU A H    1 
ATOM   828  H HA   . LEU A 1 53  ? -42.272 44.871 -3.763  1.00 42.28  ? 53  LEU A HA   1 
ATOM   829  H HB2  . LEU A 1 53  ? -42.179 42.185 -2.934  1.00 37.38  ? 53  LEU A HB2  1 
ATOM   830  H HB3  . LEU A 1 53  ? -40.914 43.001 -3.444  1.00 37.38  ? 53  LEU A HB3  1 
ATOM   831  H HG   . LEU A 1 53  ? -42.268 43.832 -1.142  1.00 40.70  ? 53  LEU A HG   1 
ATOM   832  H HD11 . LEU A 1 53  ? -41.701 41.627 -0.603  1.00 44.65  ? 53  LEU A HD11 1 
ATOM   833  H HD12 . LEU A 1 53  ? -40.695 42.564 0.194   1.00 44.65  ? 53  LEU A HD12 1 
ATOM   834  H HD13 . LEU A 1 53  ? -40.220 41.840 -1.138  1.00 44.65  ? 53  LEU A HD13 1 
ATOM   835  H HD21 . LEU A 1 53  ? -40.209 44.791 -0.508  1.00 43.08  ? 53  LEU A HD21 1 
ATOM   836  H HD22 . LEU A 1 53  ? -39.582 44.295 -1.881  1.00 43.08  ? 53  LEU A HD22 1 
ATOM   837  H HD23 . LEU A 1 53  ? -40.735 45.387 -1.883  1.00 43.08  ? 53  LEU A HD23 1 
ATOM   838  N N    . ASN A 1 54  ? -43.725 42.674 -5.557  1.00 33.78  ? 54  ASN A N    1 
ATOM   839  C CA   . ASN A 1 54  ? -44.149 42.495 -6.946  1.00 38.11  ? 54  ASN A CA   1 
ATOM   840  C C    . ASN A 1 54  ? -44.310 43.785 -7.716  1.00 41.69  ? 54  ASN A C    1 
ATOM   841  O O    . ASN A 1 54  ? -43.965 43.866 -8.902  1.00 46.17  ? 54  ASN A O    1 
ATOM   842  C CB   . ASN A 1 54  ? -45.514 41.794 -6.939  1.00 44.94  ? 54  ASN A CB   1 
ATOM   843  C CG   . ASN A 1 54  ? -45.417 40.307 -7.208  1.00 43.46  ? 54  ASN A CG   1 
ATOM   844  O OD1  . ASN A 1 54  ? -45.220 39.880 -8.323  1.00 40.94  ? 54  ASN A OD1  1 
ATOM   845  N ND2  . ASN A 1 54  ? -45.301 39.552 -6.134  1.00 46.16  ? 54  ASN A ND2  1 
ATOM   846  H H    . ASN A 1 54  ? -44.141 42.169 -4.999  1.00 40.59  ? 54  ASN A H    1 
ATOM   847  H HA   . ASN A 1 54  ? -43.460 41.974 -7.387  1.00 45.78  ? 54  ASN A HA   1 
ATOM   848  H HB2  . ASN A 1 54  ? -45.925 41.913 -6.068  1.00 53.98  ? 54  ASN A HB2  1 
ATOM   849  H HB3  . ASN A 1 54  ? -46.074 42.186 -7.627  1.00 53.98  ? 54  ASN A HB3  1 
ATOM   850  H HD21 . ASN A 1 54  ? -45.284 39.914 -5.354  1.00 55.44  ? 54  ASN A HD21 1 
ATOM   851  H HD22 . ASN A 1 54  ? -45.241 38.698 -6.213  1.00 55.44  ? 54  ASN A HD22 1 
ATOM   852  N N    . ARG A 1 55  ? -45.018 44.749 -7.125  1.00 39.22  ? 55  ARG A N    1 
ATOM   853  C CA   . ARG A 1 55  ? -45.420 45.953 -7.823  1.00 43.72  ? 55  ARG A CA   1 
ATOM   854  C C    . ARG A 1 55  ? -44.264 46.904 -8.041  1.00 47.07  ? 55  ARG A C    1 
ATOM   855  O O    . ARG A 1 55  ? -44.413 47.862 -8.815  1.00 52.30  ? 55  ARG A O    1 
ATOM   856  C CB   . ARG A 1 55  ? -46.538 46.605 -7.007  1.00 41.85  ? 55  ARG A CB   1 
ATOM   857  C CG   . ARG A 1 55  ? -47.803 45.731 -6.873  1.00 41.48  ? 55  ARG A CG   1 
ATOM   858  C CD   . ARG A 1 55  ? -48.857 46.362 -5.910  1.00 41.27  ? 55  ARG A CD   1 
ATOM   859  N NE   . ARG A 1 55  ? -49.240 47.687 -6.417  1.00 37.05  ? 55  ARG A NE   1 
ATOM   860  C CZ   . ARG A 1 55  ? -50.044 47.864 -7.457  1.00 45.13  ? 55  ARG A CZ   1 
ATOM   861  N NH1  . ARG A 1 55  ? -50.352 49.076 -7.901  1.00 45.86  ? 55  ARG A NH1  1 
ATOM   862  N NH2  . ARG A 1 55  ? -50.589 46.796 -8.018  1.00 49.20  ? 55  ARG A NH2  1 
ATOM   863  H H    . ARG A 1 55  ? -45.278 44.722 -6.306  1.00 47.11  ? 55  ARG A H    1 
ATOM   864  H HA   . ARG A 1 55  ? -45.770 45.753 -8.705  1.00 52.51  ? 55  ARG A HA   1 
ATOM   865  H HB2  . ARG A 1 55  ? -46.207 46.784 -6.113  1.00 50.27  ? 55  ARG A HB2  1 
ATOM   866  H HB3  . ARG A 1 55  ? -46.795 47.435 -7.438  1.00 50.27  ? 55  ARG A HB3  1 
ATOM   867  H HG2  . ARG A 1 55  ? -48.214 45.631 -7.746  1.00 49.83  ? 55  ARG A HG2  1 
ATOM   868  H HG3  . ARG A 1 55  ? -47.555 44.862 -6.522  1.00 49.83  ? 55  ARG A HG3  1 
ATOM   869  H HD2  . ARG A 1 55  ? -49.647 45.800 -5.870  1.00 49.58  ? 55  ARG A HD2  1 
ATOM   870  H HD3  . ARG A 1 55  ? -48.476 46.462 -5.023  1.00 49.58  ? 55  ARG A HD3  1 
ATOM   871  H HE   . ARG A 1 55  ? -48.927 48.382 -6.020  1.00 44.52  ? 55  ARG A HE   1 
ATOM   872  H HH11 . ARG A 1 55  ? -50.875 49.167 -8.577  1.00 55.08  ? 55  ARG A HH11 1 
ATOM   873  H HH12 . ARG A 1 55  ? -50.028 49.772 -7.512  1.00 55.08  ? 55  ARG A HH12 1 
ATOM   874  H HH21 . ARG A 1 55  ? -50.418 46.013 -7.707  1.00 59.09  ? 55  ARG A HH21 1 
ATOM   875  H HH22 . ARG A 1 55  ? -51.113 46.885 -8.694  1.00 59.09  ? 55  ARG A HH22 1 
ATOM   876  N N    . MET A 1 56  ? -43.110 46.644 -7.417  1.00 45.37  ? 56  MET A N    1 
ATOM   877  C CA   . MET A 1 56  ? -41.940 47.451 -7.699  1.00 43.95  ? 56  MET A CA   1 
ATOM   878  C C    . MET A 1 56  ? -41.314 47.017 -9.019  1.00 41.01  ? 56  MET A C    1 
ATOM   879  O O    . MET A 1 56  ? -41.536 45.894 -9.493  1.00 45.09  ? 56  MET A O    1 
ATOM   880  C CB   . MET A 1 56  ? -40.925 47.347 -6.570  1.00 32.71  ? 56  MET A CB   1 
ATOM   881  C CG   . MET A 1 56  ? -41.451 47.812 -5.208  1.00 39.10  ? 56  MET A CG   1 
ATOM   882  S SD   . MET A 1 56  ? -42.079 49.473 -5.419  1.00 52.64  ? 56  MET A SD   1 
ATOM   883  C CE   . MET A 1 56  ? -41.796 50.166 -3.785  1.00 53.85  ? 56  MET A CE   1 
ATOM   884  H H    . MET A 1 56  ? -42.991 46.017 -6.840  1.00 54.50  ? 56  MET A H    1 
ATOM   885  H HA   . MET A 1 56  ? -42.200 48.384 -7.757  1.00 52.79  ? 56  MET A HA   1 
ATOM   886  H HB2  . MET A 1 56  ? -40.656 46.419 -6.480  1.00 39.31  ? 56  MET A HB2  1 
ATOM   887  H HB3  . MET A 1 56  ? -40.157 47.896 -6.792  1.00 39.31  ? 56  MET A HB3  1 
ATOM   888  H HG2  . MET A 1 56  ? -42.169 47.231 -4.908  1.00 46.97  ? 56  MET A HG2  1 
ATOM   889  H HG3  . MET A 1 56  ? -40.735 47.818 -4.555  1.00 46.97  ? 56  MET A HG3  1 
ATOM   890  H HE1  . MET A 1 56  ? -42.327 49.676 -3.138  1.00 64.67  ? 56  MET A HE1  1 
ATOM   891  H HE2  . MET A 1 56  ? -42.058 51.100 -3.788  1.00 64.67  ? 56  MET A HE2  1 
ATOM   892  H HE3  . MET A 1 56  ? -40.854 50.087 -3.567  1.00 64.67  ? 56  MET A HE3  1 
ATOM   893  N N    . PRO A 1 57  ? -40.539 47.905 -9.646  1.00 44.94  ? 57  PRO A N    1 
ATOM   894  C CA   . PRO A 1 57  ? -39.741 47.488 -10.807 1.00 42.62  ? 57  PRO A CA   1 
ATOM   895  C C    . PRO A 1 57  ? -38.672 46.474 -10.391 1.00 41.96  ? 57  PRO A C    1 
ATOM   896  O O    . PRO A 1 57  ? -38.031 46.612 -9.341  1.00 33.51  ? 57  PRO A O    1 
ATOM   897  C CB   . PRO A 1 57  ? -39.133 48.803 -11.328 1.00 48.74  ? 57  PRO A CB   1 
ATOM   898  C CG   . PRO A 1 57  ? -39.166 49.781 -10.168 1.00 41.35  ? 57  PRO A CG   1 
ATOM   899  C CD   . PRO A 1 57  ? -40.224 49.266 -9.167  1.00 40.16  ? 57  PRO A CD   1 
ATOM   900  H HA   . PRO A 1 57  ? -40.299 47.108 -11.504 1.00 51.20  ? 57  PRO A HA   1 
ATOM   901  H HB2  . PRO A 1 57  ? -38.221 48.646 -11.617 1.00 58.54  ? 57  PRO A HB2  1 
ATOM   902  H HB3  . PRO A 1 57  ? -39.664 49.134 -12.070 1.00 58.54  ? 57  PRO A HB3  1 
ATOM   903  H HG2  . PRO A 1 57  ? -38.292 49.815 -9.750  1.00 49.67  ? 57  PRO A HG2  1 
ATOM   904  H HG3  . PRO A 1 57  ? -39.411 50.661 -10.496 1.00 49.67  ? 57  PRO A HG3  1 
ATOM   905  H HD2  . PRO A 1 57  ? -39.859 49.236 -8.269  1.00 48.24  ? 57  PRO A HD2  1 
ATOM   906  H HD3  . PRO A 1 57  ? -41.015 49.827 -9.186  1.00 48.24  ? 57  PRO A HD3  1 
ATOM   907  N N    . THR A 1 58  ? -38.509 45.429 -11.221 1.00 41.37  ? 58  THR A N    1 
ATOM   908  C CA   . THR A 1 58  ? -37.502 44.401 -10.924 1.00 46.86  ? 58  THR A CA   1 
ATOM   909  C C    . THR A 1 58  ? -36.076 44.968 -10.916 1.00 45.14  ? 58  THR A C    1 
ATOM   910  O O    . THR A 1 58  ? -35.249 44.545 -10.096 1.00 44.93  ? 58  THR A O    1 
ATOM   911  C CB   . THR A 1 58  ? -37.607 43.239 -11.909 1.00 48.57  ? 58  THR A CB   1 
ATOM   912  O OG1  . THR A 1 58  ? -37.585 43.723 -13.256 1.00 42.01  ? 58  THR A OG1  1 
ATOM   913  C CG2  . THR A 1 58  ? -38.904 42.428 -11.668 1.00 43.34  ? 58  THR A CG2  1 
ATOM   914  H H    . THR A 1 58  ? -38.958 45.296 -11.942 1.00 49.70  ? 58  THR A H    1 
ATOM   915  H HA   . THR A 1 58  ? -37.686 44.054 -10.037 1.00 56.28  ? 58  THR A HA   1 
ATOM   916  H HB   . THR A 1 58  ? -36.850 42.647 -11.778 1.00 58.34  ? 58  THR A HB   1 
ATOM   917  H HG1  . THR A 1 58  ? -36.823 44.024 -13.440 1.00 50.46  ? 58  THR A HG1  1 
ATOM   918  H HG21 . THR A 1 58  ? -39.679 42.968 -11.889 1.00 52.06  ? 58  THR A HG21 1 
ATOM   919  H HG22 . THR A 1 58  ? -38.905 41.632 -12.222 1.00 52.06  ? 58  THR A HG22 1 
ATOM   920  H HG23 . THR A 1 58  ? -38.961 42.163 -10.736 1.00 52.06  ? 58  THR A HG23 1 
ATOM   921  N N    . ASP A 1 59  ? -35.771 45.953 -11.768 1.00 50.24  ? 59  ASP A N    1 
ATOM   922  C CA   . ASP A 1 59  ? -34.470 46.645 -11.655 1.00 48.18  ? 59  ASP A CA   1 
ATOM   923  C C    . ASP A 1 59  ? -34.246 47.189 -10.249 1.00 38.54  ? 59  ASP A C    1 
ATOM   924  O O    . ASP A 1 59  ? -33.141 47.134 -9.714  1.00 43.08  ? 59  ASP A O    1 
ATOM   925  C CB   . ASP A 1 59  ? -34.381 47.803 -12.650 1.00 50.72  ? 59  ASP A CB   1 
ATOM   926  C CG   . ASP A 1 59  ? -34.023 47.352 -14.058 1.00 61.17  ? 59  ASP A CG   1 
ATOM   927  O OD1  . ASP A 1 59  ? -33.658 46.165 -14.225 1.00 67.55  ? 59  ASP A OD1  1 
ATOM   928  O OD2  . ASP A 1 59  ? -34.097 48.198 -14.992 1.00 69.31  ? 59  ASP A OD2  1 
ATOM   929  H H    . ASP A 1 59  ? -36.279 46.235 -12.402 1.00 60.34  ? 59  ASP A H    1 
ATOM   930  H HA   . ASP A 1 59  ? -33.777 45.999 -11.865 1.00 57.86  ? 59  ASP A HA   1 
ATOM   931  H HB2  . ASP A 1 59  ? -35.241 48.251 -12.689 1.00 60.91  ? 59  ASP A HB2  1 
ATOM   932  H HB3  . ASP A 1 59  ? -33.697 48.422 -12.351 1.00 60.91  ? 59  ASP A HB3  1 
ATOM   933  N N    . MET A 1 60  ? -35.287 47.726 -9.628  1.00 47.04  ? 60  MET A N    1 
ATOM   934  C CA   . MET A 1 60  ? -35.117 48.275 -8.285  1.00 47.62  ? 60  MET A CA   1 
ATOM   935  C C    . MET A 1 60  ? -35.050 47.166 -7.231  1.00 41.56  ? 60  MET A C    1 
ATOM   936  O O    . MET A 1 60  ? -34.218 47.218 -6.319  1.00 42.50  ? 60  MET A O    1 
ATOM   937  C CB   . MET A 1 60  ? -36.257 49.263 -8.012  1.00 42.55  ? 60  MET A CB   1 
ATOM   938  C CG   . MET A 1 60  ? -36.032 50.320 -6.921  1.00 47.40  ? 60  MET A CG   1 
ATOM   939  S SD   . MET A 1 60  ? -37.630 51.207 -6.655  1.00 61.65  ? 60  MET A SD   1 
ATOM   940  C CE   . MET A 1 60  ? -37.325 52.076 -5.118  1.00 52.12  ? 60  MET A CE   1 
ATOM   941  H H    . MET A 1 60  ? -36.082 47.785 -9.951  1.00 56.49  ? 60  MET A H    1 
ATOM   942  H HA   . MET A 1 60  ? -34.284 48.770 -8.230  1.00 57.19  ? 60  MET A HA   1 
ATOM   943  H HB2  . MET A 1 60  ? -36.439 49.743 -8.835  1.00 51.12  ? 60  MET A HB2  1 
ATOM   944  H HB3  . MET A 1 60  ? -37.037 48.750 -7.748  1.00 51.12  ? 60  MET A HB3  1 
ATOM   945  H HG2  . MET A 1 60  ? -35.759 49.895 -6.093  1.00 56.93  ? 60  MET A HG2  1 
ATOM   946  H HG3  . MET A 1 60  ? -35.356 50.956 -7.206  1.00 56.93  ? 60  MET A HG3  1 
ATOM   947  H HE1  . MET A 1 60  ? -37.068 51.434 -4.438  1.00 62.59  ? 60  MET A HE1  1 
ATOM   948  H HE2  . MET A 1 60  ? -38.136 52.535 -4.849  1.00 62.59  ? 60  MET A HE2  1 
ATOM   949  H HE3  . MET A 1 60  ? -36.611 52.718 -5.254  1.00 62.59  ? 60  MET A HE3  1 
ATOM   950  N N    . LEU A 1 61  ? -35.902 46.150 -7.330  1.00 44.77  ? 61  LEU A N    1 
ATOM   951  C CA   . LEU A 1 61  ? -35.772 45.025 -6.411  1.00 44.92  ? 61  LEU A CA   1 
ATOM   952  C C    . LEU A 1 61  ? -34.367 44.460 -6.475  1.00 44.42  ? 61  LEU A C    1 
ATOM   953  O O    . LEU A 1 61  ? -33.731 44.218 -5.438  1.00 38.14  ? 61  LEU A O    1 
ATOM   954  C CB   . LEU A 1 61  ? -36.787 43.945 -6.767  1.00 39.64  ? 61  LEU A CB   1 
ATOM   955  C CG   . LEU A 1 61  ? -36.911 42.743 -5.849  1.00 39.25  ? 61  LEU A CG   1 
ATOM   956  C CD1  . LEU A 1 61  ? -37.459 43.155 -4.541  1.00 37.51  ? 61  LEU A CD1  1 
ATOM   957  C CD2  . LEU A 1 61  ? -37.830 41.783 -6.566  1.00 41.93  ? 61  LEU A CD2  1 
ATOM   958  H H    . LEU A 1 61  ? -36.542 46.089 -7.901  1.00 53.78  ? 61  LEU A H    1 
ATOM   959  H HA   . LEU A 1 61  ? -35.954 45.322 -5.506  1.00 53.96  ? 61  LEU A HA   1 
ATOM   960  H HB2  . LEU A 1 61  ? -37.662 44.363 -6.797  1.00 47.62  ? 61  LEU A HB2  1 
ATOM   961  H HB3  . LEU A 1 61  ? -36.554 43.601 -7.644  1.00 47.62  ? 61  LEU A HB3  1 
ATOM   962  H HG   . LEU A 1 61  ? -36.059 42.321 -5.658  1.00 47.15  ? 61  LEU A HG   1 
ATOM   963  H HD11 . LEU A 1 61  ? -38.280 43.652 -4.685  1.00 45.06  ? 61  LEU A HD11 1 
ATOM   964  H HD12 . LEU A 1 61  ? -36.809 43.715 -4.088  1.00 45.06  ? 61  LEU A HD12 1 
ATOM   965  H HD13 . LEU A 1 61  ? -37.641 42.364 -4.011  1.00 45.06  ? 61  LEU A HD13 1 
ATOM   966  H HD21 . LEU A 1 61  ? -38.175 41.139 -5.928  1.00 50.36  ? 61  LEU A HD21 1 
ATOM   967  H HD22 . LEU A 1 61  ? -37.329 41.325 -7.260  1.00 50.36  ? 61  LEU A HD22 1 
ATOM   968  H HD23 . LEU A 1 61  ? -38.562 42.282 -6.962  1.00 50.36  ? 61  LEU A HD23 1 
ATOM   969  N N    . LYS A 1 62  ? -33.855 44.267 -7.695  1.00 49.18  ? 62  LYS A N    1 
ATOM   970  C CA   . LYS A 1 62  ? -32.497 43.744 -7.863  1.00 45.94  ? 62  LYS A CA   1 
ATOM   971  C C    . LYS A 1 62  ? -31.499 44.583 -7.082  1.00 42.34  ? 62  LYS A C    1 
ATOM   972  O O    . LYS A 1 62  ? -30.639 44.050 -6.368  1.00 42.86  ? 62  LYS A O    1 
ATOM   973  C CB   . LYS A 1 62  ? -32.141 43.707 -9.354  1.00 49.08  ? 62  LYS A CB   1 
ATOM   974  C CG   . LYS A 1 62  ? -30.943 42.869 -9.728  1.00 49.54  ? 62  LYS A CG   1 
ATOM   975  C CD   . LYS A 1 62  ? -30.514 43.061 -11.190 1.00 60.93  ? 62  LYS A CD   1 
ATOM   976  C CE   . LYS A 1 62  ? -31.529 42.523 -12.200 1.00 73.23  ? 62  LYS A CE   1 
ATOM   977  N NZ   . LYS A 1 62  ? -31.086 42.628 -13.631 1.00 77.40  ? 62  LYS A NZ   1 
ATOM   978  H H    . LYS A 1 62  ? -34.268 44.428 -8.431  1.00 59.07  ? 62  LYS A H    1 
ATOM   979  H HA   . LYS A 1 62  ? -32.453 42.836 -7.524  1.00 55.18  ? 62  LYS A HA   1 
ATOM   980  H HB2  . LYS A 1 62  ? -32.902 43.351 -9.839  1.00 58.95  ? 62  LYS A HB2  1 
ATOM   981  H HB3  . LYS A 1 62  ? -31.958 44.614 -9.645  1.00 58.95  ? 62  LYS A HB3  1 
ATOM   982  H HG2  . LYS A 1 62  ? -30.196 43.115 -9.161  1.00 59.50  ? 62  LYS A HG2  1 
ATOM   983  H HG3  . LYS A 1 62  ? -31.161 41.932 -9.601  1.00 59.50  ? 62  LYS A HG3  1 
ATOM   984  H HD2  . LYS A 1 62  ? -30.399 44.009 -11.361 1.00 73.17  ? 62  LYS A HD2  1 
ATOM   985  H HD3  . LYS A 1 62  ? -29.676 42.595 -11.335 1.00 73.17  ? 62  LYS A HD3  1 
ATOM   986  H HE2  . LYS A 1 62  ? -31.690 41.585 -12.010 1.00 87.92  ? 62  LYS A HE2  1 
ATOM   987  H HE3  . LYS A 1 62  ? -32.354 43.026 -12.110 1.00 87.92  ? 62  LYS A HE3  1 
ATOM   988  H HZ1  . LYS A 1 62  ? -31.788 42.552 -14.174 1.00 92.93  ? 62  LYS A HZ1  1 
ATOM   989  H HZ2  . LYS A 1 62  ? -30.696 43.415 -13.772 1.00 92.93  ? 62  LYS A HZ2  1 
ATOM   990  H HZ3  . LYS A 1 62  ? -30.505 41.980 -13.818 1.00 92.93  ? 62  LYS A HZ3  1 
ATOM   991  N N    . LEU A 1 63  ? -31.610 45.911 -7.192  1.00 46.21  ? 63  LEU A N    1 
ATOM   992  C CA   . LEU A 1 63  ? -30.636 46.791 -6.543  1.00 50.57  ? 63  LEU A CA   1 
ATOM   993  C C    . LEU A 1 63  ? -30.747 46.716 -5.025  1.00 50.64  ? 63  LEU A C    1 
ATOM   994  O O    . LEU A 1 63  ? -29.741 46.632 -4.317  1.00 52.14  ? 63  LEU A O    1 
ATOM   995  C CB   . LEU A 1 63  ? -30.824 48.238 -7.007  1.00 53.12  ? 63  LEU A CB   1 
ATOM   996  C CG   . LEU A 1 63  ? -29.838 49.279 -6.452  1.00 59.66  ? 63  LEU A CG   1 
ATOM   997  C CD1  . LEU A 1 63  ? -28.447 48.933 -7.003  1.00 68.58  ? 63  LEU A CD1  1 
ATOM   998  C CD2  . LEU A 1 63  ? -30.239 50.706 -6.798  1.00 62.58  ? 63  LEU A CD2  1 
ATOM   999  H H    . LEU A 1 63  ? -32.228 46.320 -7.629  1.00 55.50  ? 63  LEU A H    1 
ATOM   1000 H HA   . LEU A 1 63  ? -29.748 46.499 -6.804  1.00 60.73  ? 63  LEU A HA   1 
ATOM   1001 H HB2  . LEU A 1 63  ? -30.741 48.256 -7.973  1.00 63.79  ? 63  LEU A HB2  1 
ATOM   1002 H HB3  . LEU A 1 63  ? -31.714 48.523 -6.745  1.00 63.79  ? 63  LEU A HB3  1 
ATOM   1003 H HG   . LEU A 1 63  ? -29.832 49.250 -5.483  1.00 71.64  ? 63  LEU A HG   1 
ATOM   1004 H HD11 . LEU A 1 63  ? -28.107 48.155 -6.535  1.00 82.35  ? 63  LEU A HD11 1 
ATOM   1005 H HD12 . LEU A 1 63  ? -27.855 49.688 -6.864  1.00 82.35  ? 63  LEU A HD12 1 
ATOM   1006 H HD13 . LEU A 1 63  ? -28.522 48.741 -7.951  1.00 82.35  ? 63  LEU A HD13 1 
ATOM   1007 H HD21 . LEU A 1 63  ? -30.288 50.795 -7.763  1.00 75.15  ? 63  LEU A HD21 1 
ATOM   1008 H HD22 . LEU A 1 63  ? -29.574 51.316 -6.443  1.00 75.15  ? 63  LEU A HD22 1 
ATOM   1009 H HD23 . LEU A 1 63  ? -31.105 50.895 -6.404  1.00 75.15  ? 63  LEU A HD23 1 
ATOM   1010 N N    . PHE A 1 64  ? -31.959 46.801 -4.500  1.00 46.95  ? 64  PHE A N    1 
ATOM   1011 C CA   . PHE A 1 64  ? -32.087 46.849 -3.060  1.00 42.42  ? 64  PHE A CA   1 
ATOM   1012 C C    . PHE A 1 64  ? -31.896 45.489 -2.414  1.00 36.62  ? 64  PHE A C    1 
ATOM   1013 O O    . PHE A 1 64  ? -31.791 45.422 -1.189  1.00 37.58  ? 64  PHE A O    1 
ATOM   1014 C CB   . PHE A 1 64  ? -33.449 47.432 -2.687  1.00 44.69  ? 64  PHE A CB   1 
ATOM   1015 C CG   . PHE A 1 64  ? -33.507 48.925 -2.743  1.00 47.89  ? 64  PHE A CG   1 
ATOM   1016 C CD1  . PHE A 1 64  ? -33.567 49.592 -3.953  1.00 45.92  ? 64  PHE A CD1  1 
ATOM   1017 C CD2  . PHE A 1 64  ? -33.500 49.665 -1.585  1.00 49.41  ? 64  PHE A CD2  1 
ATOM   1018 C CE1  . PHE A 1 64  ? -33.640 50.961 -3.984  1.00 48.22  ? 64  PHE A CE1  1 
ATOM   1019 C CE2  . PHE A 1 64  ? -33.552 51.023 -1.632  1.00 52.49  ? 64  PHE A CE2  1 
ATOM   1020 C CZ   . PHE A 1 64  ? -33.642 51.668 -2.828  1.00 46.82  ? 64  PHE A CZ   1 
ATOM   1021 H H    . PHE A 1 64  ? -32.695 46.831 -4.944  1.00 56.39  ? 64  PHE A H    1 
ATOM   1022 H HA   . PHE A 1 64  ? -31.408 47.438 -2.695  1.00 50.96  ? 64  PHE A HA   1 
ATOM   1023 H HB2  . PHE A 1 64  ? -34.114 47.087 -3.303  1.00 53.67  ? 64  PHE A HB2  1 
ATOM   1024 H HB3  . PHE A 1 64  ? -33.665 47.162 -1.780  1.00 53.67  ? 64  PHE A HB3  1 
ATOM   1025 H HD1  . PHE A 1 64  ? -33.558 49.111 -4.748  1.00 55.15  ? 64  PHE A HD1  1 
ATOM   1026 H HD2  . PHE A 1 64  ? -33.460 49.234 -0.762  1.00 59.34  ? 64  PHE A HD2  1 
ATOM   1027 H HE1  . PHE A 1 64  ? -33.689 51.405 -4.800  1.00 57.92  ? 64  PHE A HE1  1 
ATOM   1028 H HE2  . PHE A 1 64  ? -33.525 51.514 -0.842  1.00 63.03  ? 64  PHE A HE2  1 
ATOM   1029 H HZ   . PHE A 1 64  ? -33.704 52.595 -2.851  1.00 56.24  ? 64  PHE A HZ   1 
ATOM   1030 N N    . THR A 1 65  ? -31.836 44.405 -3.178  1.00 39.07  ? 65  THR A N    1 
ATOM   1031 C CA   . THR A 1 65  ? -31.543 43.112 -2.573  1.00 47.67  ? 65  THR A CA   1 
ATOM   1032 C C    . THR A 1 65  ? -30.168 42.583 -2.946  1.00 51.59  ? 65  THR A C    1 
ATOM   1033 O O    . THR A 1 65  ? -29.827 41.470 -2.557  1.00 51.00  ? 65  THR A O    1 
ATOM   1034 C CB   . THR A 1 65  ? -32.606 42.074 -2.944  1.00 42.53  ? 65  THR A CB   1 
ATOM   1035 O OG1  . THR A 1 65  ? -32.742 42.003 -4.358  1.00 43.28  ? 65  THR A OG1  1 
ATOM   1036 C CG2  . THR A 1 65  ? -33.957 42.452 -2.352  1.00 49.60  ? 65  THR A CG2  1 
ATOM   1037 H H    . THR A 1 65  ? -31.958 44.394 -4.029  1.00 46.93  ? 65  THR A H    1 
ATOM   1038 H HA   . THR A 1 65  ? -31.571 43.232 -1.611  1.00 57.25  ? 65  THR A HA   1 
ATOM   1039 H HB   . THR A 1 65  ? -32.336 41.211 -2.593  1.00 51.08  ? 65  THR A HB   1 
ATOM   1040 H HG1  . THR A 1 65  ? -31.984 41.980 -4.719  1.00 51.99  ? 65  THR A HG1  1 
ATOM   1041 H HG21 . THR A 1 65  ? -34.000 42.180 -1.422  1.00 59.57  ? 65  THR A HG21 1 
ATOM   1042 H HG22 . THR A 1 65  ? -34.669 42.012 -2.843  1.00 59.57  ? 65  THR A HG22 1 
ATOM   1043 H HG23 . THR A 1 65  ? -34.086 43.412 -2.405  1.00 59.57  ? 65  THR A HG23 1 
ATOM   1044 N N    . HIS A 1 66  ? -29.356 43.360 -3.662  1.00 57.10  ? 66  HIS A N    1 
ATOM   1045 C CA   . HIS A 1 66  ? -28.051 42.864 -4.101  1.00 67.13  ? 66  HIS A CA   1 
ATOM   1046 C C    . HIS A 1 66  ? -27.205 42.339 -2.942  1.00 62.15  ? 66  HIS A C    1 
ATOM   1047 O O    . HIS A 1 66  ? -26.608 41.266 -3.040  1.00 64.25  ? 66  HIS A O    1 
ATOM   1048 C CB   . HIS A 1 66  ? -27.279 43.962 -4.844  1.00 72.67  ? 66  HIS A CB   1 
ATOM   1049 C CG   . HIS A 1 66  ? -25.896 43.552 -5.261  1.00 75.98  ? 66  HIS A CG   1 
ATOM   1050 N ND1  . HIS A 1 66  ? -24.783 43.761 -4.471  1.00 73.15  ? 66  HIS A ND1  1 
ATOM   1051 C CD2  . HIS A 1 66  ? -25.450 42.932 -6.380  1.00 79.09  ? 66  HIS A CD2  1 
ATOM   1052 C CE1  . HIS A 1 66  ? -23.712 43.295 -5.089  1.00 78.82  ? 66  HIS A CE1  1 
ATOM   1053 N NE2  . HIS A 1 66  ? -24.089 42.791 -6.252  1.00 78.64  ? 66  HIS A NE2  1 
ATOM   1054 H H    . HIS A 1 66  ? -29.534 44.166 -3.904  1.00 68.57  ? 66  HIS A H    1 
ATOM   1055 H HA   . HIS A 1 66  ? -28.216 42.129 -4.711  1.00 80.61  ? 66  HIS A HA   1 
ATOM   1056 H HB2  . HIS A 1 66  ? -27.771 44.202 -5.644  1.00 87.26  ? 66  HIS A HB2  1 
ATOM   1057 H HB3  . HIS A 1 66  ? -27.196 44.734 -4.261  1.00 87.26  ? 66  HIS A HB3  1 
ATOM   1058 H HD1  . HIS A 1 66  ? -24.787 44.136 -3.697  1.00 87.83  ? 66  HIS A HD1  1 
ATOM   1059 H HD2  . HIS A 1 66  ? -25.968 42.654 -7.100  1.00 94.96  ? 66  HIS A HD2  1 
ATOM   1060 H HE1  . HIS A 1 66  ? -22.842 43.319 -4.763  1.00 94.64  ? 66  HIS A HE1  1 
ATOM   1061 N N    . ASP A 1 67  ? -27.108 43.095 -1.854  1.00 57.52  ? 67  ASP A N    1 
ATOM   1062 C CA   . ASP A 1 67  ? -26.129 42.781 -0.822  1.00 67.93  ? 67  ASP A CA   1 
ATOM   1063 C C    . ASP A 1 67  ? -26.617 41.754 0.189   1.00 67.07  ? 67  ASP A C    1 
ATOM   1064 O O    . ASP A 1 67  ? -25.819 41.319 1.029   1.00 69.59  ? 67  ASP A O    1 
ATOM   1065 C CB   . ASP A 1 67  ? -25.735 44.053 -0.077  1.00 78.09  ? 67  ASP A CB   1 
ATOM   1066 C CG   . ASP A 1 67  ? -24.768 44.899 -0.866  1.00 84.59  ? 67  ASP A CG   1 
ATOM   1067 O OD1  . ASP A 1 67  ? -23.605 44.465 -1.083  1.00 89.75  ? 67  ASP A OD1  1 
ATOM   1068 O OD2  . ASP A 1 67  ? -25.196 45.993 -1.276  1.00 73.27  ? 67  ASP A OD2  1 
ATOM   1069 H H    . ASP A 1 67  ? -27.592 43.787 -1.692  1.00 69.07  ? 67  ASP A H    1 
ATOM   1070 H HA   . ASP A 1 67  ? -25.342 42.416 -1.258  1.00 81.57  ? 67  ASP A HA   1 
ATOM   1071 H HB2  . ASP A 1 67  ? -26.530 44.581 0.093   1.00 93.76  ? 67  ASP A HB2  1 
ATOM   1072 H HB3  . ASP A 1 67  ? -25.311 43.812 0.762   1.00 93.76  ? 67  ASP A HB3  1 
ATOM   1073 N N    . ILE A 1 68  ? -27.878 41.352 0.114   1.00 54.16  ? 68  ILE A N    1 
ATOM   1074 C CA   . ILE A 1 68  ? -28.465 40.421 1.071   1.00 65.65  ? 68  ILE A CA   1 
ATOM   1075 C C    . ILE A 1 68  ? -28.885 39.111 0.428   1.00 65.01  ? 68  ILE A C    1 
ATOM   1076 O O    . ILE A 1 68  ? -29.186 38.150 1.156   1.00 69.27  ? 68  ILE A O    1 
ATOM   1077 C CB   . ILE A 1 68  ? -29.669 41.064 1.794   1.00 55.68  ? 68  ILE A CB   1 
ATOM   1078 C CG1  . ILE A 1 68  ? -30.774 41.381 0.790   1.00 47.82  ? 68  ILE A CG1  1 
ATOM   1079 C CG2  . ILE A 1 68  ? -29.240 42.347 2.484   1.00 53.05  ? 68  ILE A CG2  1 
ATOM   1080 C CD1  . ILE A 1 68  ? -31.994 42.043 1.408   1.00 57.30  ? 68  ILE A CD1  1 
ATOM   1081 H H    . ILE A 1 68  ? -28.428 41.610 -0.495  1.00 65.05  ? 68  ILE A H    1 
ATOM   1082 H HA   . ILE A 1 68  ? -27.798 40.206 1.742   1.00 78.83  ? 68  ILE A HA   1 
ATOM   1083 H HB   . ILE A 1 68  ? -30.001 40.435 2.453   1.00 66.86  ? 68  ILE A HB   1 
ATOM   1084 H HG12 . ILE A 1 68  ? -30.420 41.983 0.117   1.00 57.43  ? 68  ILE A HG12 1 
ATOM   1085 H HG13 . ILE A 1 68  ? -31.065 40.554 0.375   1.00 57.43  ? 68  ILE A HG13 1 
ATOM   1086 H HG21 . ILE A 1 68  ? -28.538 42.143 3.122   1.00 63.72  ? 68  ILE A HG21 1 
ATOM   1087 H HG22 . ILE A 1 68  ? -30.004 42.730 2.944   1.00 63.72  ? 68  ILE A HG22 1 
ATOM   1088 H HG23 . ILE A 1 68  ? -28.910 42.970 1.817   1.00 63.72  ? 68  ILE A HG23 1 
ATOM   1089 H HD11 . ILE A 1 68  ? -32.729 42.003 0.776   1.00 68.81  ? 68  ILE A HD11 1 
ATOM   1090 H HD12 . ILE A 1 68  ? -32.231 41.572 2.222   1.00 68.81  ? 68  ILE A HD12 1 
ATOM   1091 H HD13 . ILE A 1 68  ? -31.783 42.968 1.611   1.00 68.81  ? 68  ILE A HD13 1 
ATOM   1092 N N    . MET A 1 69  ? -28.959 39.031 -0.904  1.00 69.00  ? 69  MET A N    1 
ATOM   1093 C CA   . MET A 1 69  ? -29.098 37.731 -1.552  1.00 74.65  ? 69  MET A CA   1 
ATOM   1094 C C    . MET A 1 69  ? -27.760 37.015 -1.408  1.00 73.74  ? 69  MET A C    1 
ATOM   1095 O O    . MET A 1 69  ? -26.751 37.462 -1.973  1.00 79.64  ? 69  MET A O    1 
ATOM   1096 C CB   . MET A 1 69  ? -29.479 37.866 -3.027  1.00 70.39  ? 69  MET A CB   1 
ATOM   1097 C CG   . MET A 1 69  ? -30.845 38.403 -3.273  1.00 56.84  ? 69  MET A CG   1 
ATOM   1098 S SD   . MET A 1 69  ? -32.064 37.162 -3.634  1.00 78.29  ? 69  MET A SD   1 
ATOM   1099 C CE   . MET A 1 69  ? -31.826 36.837 -5.394  1.00 65.56  ? 69  MET A CE   1 
ATOM   1100 H H    . MET A 1 69  ? -28.932 39.702 -1.440  1.00 82.86  ? 69  MET A H    1 
ATOM   1101 H HA   . MET A 1 69  ? -29.817 37.237 -1.129  1.00 89.63  ? 69  MET A HA   1 
ATOM   1102 H HB2  . MET A 1 69  ? -28.849 38.467 -3.454  1.00 84.52  ? 69  MET A HB2  1 
ATOM   1103 H HB3  . MET A 1 69  ? -29.432 36.989 -3.438  1.00 84.52  ? 69  MET A HB3  1 
ATOM   1104 H HG2  . MET A 1 69  ? -31.138 38.880 -2.482  1.00 68.26  ? 69  MET A HG2  1 
ATOM   1105 H HG3  . MET A 1 69  ? -30.808 39.007 -4.031  1.00 68.26  ? 69  MET A HG3  1 
ATOM   1106 H HE1  . MET A 1 69  ? -32.429 36.128 -5.668  1.00 78.72  ? 69  MET A HE1  1 
ATOM   1107 H HE2  . MET A 1 69  ? -32.019 37.646 -5.894  1.00 78.72  ? 69  MET A HE2  1 
ATOM   1108 H HE3  . MET A 1 69  ? -30.907 36.566 -5.544  1.00 78.72  ? 69  MET A HE3  1 
ATOM   1109 N N    . LEU A 1 70  ? -27.736 35.978 -0.623  1.00 68.27  ? 70  LEU A N    1 
ATOM   1110 C CA   . LEU A 1 70  ? -26.556 35.140 -0.531  1.00 72.67  ? 70  LEU A CA   1 
ATOM   1111 C C    . LEU A 1 70  ? -26.751 33.886 -1.373  1.00 71.79  ? 70  LEU A C    1 
ATOM   1112 O O    . LEU A 1 70  ? -27.892 33.504 -1.691  1.00 54.89  ? 70  LEU A O    1 
ATOM   1113 C CB   . LEU A 1 70  ? -26.278 34.765 0.936   1.00 75.11  ? 70  LEU A CB   1 
ATOM   1114 C CG   . LEU A 1 70  ? -26.392 35.911 1.967   1.00 78.91  ? 70  LEU A CG   1 
ATOM   1115 C CD1  . LEU A 1 70  ? -26.106 35.474 3.422   1.00 73.77  ? 70  LEU A CD1  1 
ATOM   1116 C CD2  . LEU A 1 70  ? -25.468 37.078 1.539   1.00 70.59  ? 70  LEU A CD2  1 
ATOM   1117 H H    . LEU A 1 70  ? -28.391 35.728 -0.125  1.00 81.97  ? 70  LEU A H    1 
ATOM   1118 H HA   . LEU A 1 70  ? -25.776 35.615 -0.859  1.00 87.26  ? 70  LEU A HA   1 
ATOM   1119 H HB2  . LEU A 1 70  ? -26.914 34.080 1.197   1.00 90.19  ? 70  LEU A HB2  1 
ATOM   1120 H HB3  . LEU A 1 70  ? -25.374 34.418 0.993   1.00 90.19  ? 70  LEU A HB3  1 
ATOM   1121 H HG   . LEU A 1 70  ? -27.315 36.210 1.977   1.00 94.74  ? 70  LEU A HG   1 
ATOM   1122 H HD11 . LEU A 1 70  ? -26.942 35.235 3.850   1.00 88.58  ? 70  LEU A HD11 1 
ATOM   1123 H HD12 . LEU A 1 70  ? -25.690 36.211 3.897   1.00 88.58  ? 70  LEU A HD12 1 
ATOM   1124 H HD13 . LEU A 1 70  ? -25.509 34.710 3.410   1.00 88.58  ? 70  LEU A HD13 1 
ATOM   1125 H HD21 . LEU A 1 70  ? -25.716 37.365 0.646   1.00 84.76  ? 70  LEU A HD21 1 
ATOM   1126 H HD22 . LEU A 1 70  ? -24.548 36.771 1.545   1.00 84.76  ? 70  LEU A HD22 1 
ATOM   1127 H HD23 . LEU A 1 70  ? -25.576 37.812 2.164   1.00 84.76  ? 70  LEU A HD23 1 
ATOM   1128 N N    . PRO A 1 71  ? -25.660 33.239 -1.790  1.00 71.16  ? 71  PRO A N    1 
ATOM   1129 C CA   . PRO A 1 71  ? -25.788 31.859 -2.279  1.00 67.88  ? 71  PRO A CA   1 
ATOM   1130 C C    . PRO A 1 71  ? -26.483 31.016 -1.214  1.00 52.44  ? 71  PRO A C    1 
ATOM   1131 O O    . PRO A 1 71  ? -26.061 31.033 -0.055  1.00 60.83  ? 71  PRO A O    1 
ATOM   1132 C CB   . PRO A 1 71  ? -24.334 31.418 -2.525  1.00 80.23  ? 71  PRO A CB   1 
ATOM   1133 C CG   . PRO A 1 71  ? -23.461 32.666 -2.414  1.00 78.71  ? 71  PRO A CG   1 
ATOM   1134 C CD   . PRO A 1 71  ? -24.259 33.675 -1.610  1.00 74.77  ? 71  PRO A CD   1 
ATOM   1135 H HA   . PRO A 1 71  ? -26.267 31.812 -3.121  1.00 81.51  ? 71  PRO A HA   1 
ATOM   1136 H HB2  . PRO A 1 71  ? -24.078 30.764 -1.855  1.00 96.32  ? 71  PRO A HB2  1 
ATOM   1137 H HB3  . PRO A 1 71  ? -24.261 31.030 -3.411  1.00 96.32  ? 71  PRO A HB3  1 
ATOM   1138 H HG2  . PRO A 1 71  ? -22.633 32.445 -1.959  1.00 94.51  ? 71  PRO A HG2  1 
ATOM   1139 H HG3  . PRO A 1 71  ? -23.270 33.010 -3.301  1.00 94.51  ? 71  PRO A HG3  1 
ATOM   1140 H HD2  . PRO A 1 71  ? -24.007 33.644 -0.673  1.00 89.77  ? 71  PRO A HD2  1 
ATOM   1141 H HD3  . PRO A 1 71  ? -24.131 34.571 -1.958  1.00 89.77  ? 71  PRO A HD3  1 
ATOM   1142 N N    . GLU A 1 72  ? -27.589 30.324 -1.589  1.00 54.17  ? 72  GLU A N    1 
ATOM   1143 C CA   . GLU A 1 72  ? -28.295 29.482 -0.625  1.00 44.05  ? 72  GLU A CA   1 
ATOM   1144 C C    . GLU A 1 72  ? -27.464 28.207 -0.477  1.00 49.30  ? 72  GLU A C    1 
ATOM   1145 O O    . GLU A 1 72  ? -27.182 27.490 -1.452  1.00 45.39  ? 72  GLU A O    1 
ATOM   1146 C CB   . GLU A 1 72  ? -29.692 29.210 -1.096  1.00 50.24  ? 72  GLU A CB   1 
ATOM   1147 C CG   . GLU A 1 72  ? -30.274 30.700 -1.416  1.00 54.52  ? 72  GLU A CG   1 
ATOM   1148 C CD   . GLU A 1 72  ? -31.622 30.633 -2.032  1.00 46.27  ? 72  GLU A CD   1 
ATOM   1149 O OE1  . GLU A 1 72  ? -32.291 29.623 -2.338  1.00 54.73  ? 72  GLU A OE1  1 
ATOM   1150 O OE2  . GLU A 1 72  ? -31.804 31.613 -2.632  1.00 58.60  ? 72  GLU A OE2  1 
ATOM   1151 H H    . GLU A 1 72  ? -27.930 30.334 -2.379  1.00 65.05  ? 72  GLU A H    1 
ATOM   1152 H HA   . GLU A 1 72  ? -28.385 29.911 0.241   1.00 52.91  ? 72  GLU A HA   1 
ATOM   1153 H HB2  . GLU A 1 72  ? -29.692 28.666 -1.899  1.00 60.34  ? 72  GLU A HB2  1 
ATOM   1154 H HB3  . GLU A 1 72  ? -30.219 28.780 -0.405  1.00 60.34  ? 72  GLU A HB3  1 
ATOM   1155 H HG2  . GLU A 1 72  ? -30.340 31.204 -0.589  1.00 65.48  ? 72  GLU A HG2  1 
ATOM   1156 H HG3  . GLU A 1 72  ? -29.677 31.153 -2.032  1.00 65.48  ? 72  GLU A HG3  1 
ATOM   1157 N N    . SER A 1 73  ? -27.008 27.954 0.734   1.00 43.86  ? 73  SER A N    1 
ATOM   1158 C CA   . SER A 1 73  ? -26.219 26.760 0.985   1.00 53.10  ? 73  SER A CA   1 
ATOM   1159 C C    . SER A 1 73  ? -26.830 25.845 2.040   1.00 50.90  ? 73  SER A C    1 
ATOM   1160 O O    . SER A 1 73  ? -26.106 25.044 2.647   1.00 40.37  ? 73  SER A O    1 
ATOM   1161 C CB   . SER A 1 73  ? -24.809 27.150 1.410   1.00 49.82  ? 73  SER A CB   1 
ATOM   1162 O OG   . SER A 1 73  ? -24.902 27.817 2.650   1.00 49.35  ? 73  SER A OG   1 
ATOM   1163 H H    . SER A 1 73  ? -27.140 28.453 1.422   1.00 52.69  ? 73  SER A H    1 
ATOM   1164 H HA   . SER A 1 73  ? -26.179 26.255 0.158   1.00 63.77  ? 73  SER A HA   1 
ATOM   1165 H HB2  . SER A 1 73  ? -24.263 26.354 1.506   1.00 59.83  ? 73  SER A HB2  1 
ATOM   1166 H HB3  . SER A 1 73  ? -24.419 27.742 0.748   1.00 59.83  ? 73  SER A HB3  1 
ATOM   1167 H HG   . SER A 1 73  ? -25.478 28.426 2.606   1.00 59.27  ? 73  SER A HG   1 
ATOM   1168 N N    . ASP A 1 74  ? -28.129 25.837 2.263   1.00 46.91  ? 74  ASP A N    1 
ATOM   1169 C CA   . ASP A 1 74  ? -28.724 25.063 3.385   1.00 50.64  ? 74  ASP A CA   1 
ATOM   1170 C C    . ASP A 1 74  ? -28.644 23.532 3.156   1.00 52.18  ? 74  ASP A C    1 
ATOM   1171 O O    . ASP A 1 74  ? -28.313 22.842 4.101   1.00 50.93  ? 74  ASP A O    1 
ATOM   1172 C CB   . ASP A 1 74  ? -30.097 25.657 3.675   1.00 41.02  ? 74  ASP A CB   1 
ATOM   1173 C CG   . ASP A 1 74  ? -31.110 25.418 2.599   1.00 36.92  ? 74  ASP A CG   1 
ATOM   1174 O OD1  . ASP A 1 74  ? -30.801 24.666 1.695   1.00 40.90  ? 74  ASP A OD1  1 
ATOM   1175 O OD2  . ASP A 1 74  ? -32.192 25.915 2.731   1.00 36.58  ? 74  ASP A OD2  1 
ATOM   1176 H H    . ASP A 1 74  ? -28.729 26.305 1.760   1.00 56.35  ? 74  ASP A H    1 
ATOM   1177 H HA   . ASP A 1 74  ? -28.184 25.246 4.180   1.00 60.82  ? 74  ASP A HA   1 
ATOM   1178 H HB2  . ASP A 1 74  ? -30.439 25.254 4.495   1.00 49.27  ? 74  ASP A HB2  1 
ATOM   1179 H HB3  . ASP A 1 74  ? -30.012 26.621 3.816   1.00 49.27  ? 74  ASP A HB3  1 
ATOM   1180 N N    . LEU A 1 75  ? -28.870 23.021 1.957   1.00 44.28  ? 75  LEU A N    1 
ATOM   1181 C CA   . LEU A 1 75  ? -28.881 21.565 1.702   1.00 50.68  ? 75  LEU A CA   1 
ATOM   1182 C C    . LEU A 1 75  ? -27.472 20.999 1.875   1.00 57.04  ? 75  LEU A C    1 
ATOM   1183 O O    . LEU A 1 75  ? -27.368 19.912 2.402   1.00 52.45  ? 75  LEU A O    1 
ATOM   1184 C CB   . LEU A 1 75  ? -29.423 21.289 0.302   1.00 51.52  ? 75  LEU A CB   1 
ATOM   1185 C CG   . LEU A 1 75  ? -30.936 21.152 0.166   1.00 52.88  ? 75  LEU A CG   1 
ATOM   1186 C CD1  . LEU A 1 75  ? -31.329 21.016 -1.291  1.00 46.01  ? 75  LEU A CD1  1 
ATOM   1187 C CD2  . LEU A 1 75  ? -31.457 19.967 0.951   1.00 51.04  ? 75  LEU A CD2  1 
ATOM   1188 H H    . LEU A 1 75  ? -29.023 23.533 1.221   1.00 53.18  ? 75  LEU A H    1 
ATOM   1189 H HA   . LEU A 1 75  ? -29.468 21.143 2.368   1.00 60.87  ? 75  LEU A HA   1 
ATOM   1190 H HB2  . LEU A 1 75  ? -29.126 22.010 -0.287  1.00 61.88  ? 75  LEU A HB2  1 
ATOM   1191 H HB3  . LEU A 1 75  ? -29.012 20.462 -0.021  1.00 61.88  ? 75  LEU A HB3  1 
ATOM   1192 H HG   . LEU A 1 75  ? -31.356 21.972 0.526   1.00 63.51  ? 75  LEU A HG   1 
ATOM   1193 H HD11 . LEU A 1 75  ? -31.096 21.831 -1.768  1.00 55.26  ? 75  LEU A HD11 1 
ATOM   1194 H HD12 . LEU A 1 75  ? -30.856 20.262 -1.685  1.00 55.26  ? 75  LEU A HD12 1 
ATOM   1195 H HD13 . LEU A 1 75  ? -32.288 20.865 -1.357  1.00 55.26  ? 75  LEU A HD13 1 
ATOM   1196 H HD21 . LEU A 1 75  ? -30.837 19.222 0.863   1.00 61.30  ? 75  LEU A HD21 1 
ATOM   1197 H HD22 . LEU A 1 75  ? -31.540 20.209 1.890   1.00 61.30  ? 75  LEU A HD22 1 
ATOM   1198 H HD23 . LEU A 1 75  ? -32.329 19.707 0.606   1.00 61.30  ? 75  LEU A HD23 1 
ATOM   1199 N N    . ASP A 1 76  ? -26.437 21.737 1.479   1.00 59.83  ? 76  ASP A N    1 
ATOM   1200 C CA   . ASP A 1 76  ? -25.023 21.296 1.593   1.00 59.09  ? 76  ASP A CA   1 
ATOM   1201 C C    . ASP A 1 76  ? -24.705 21.094 3.068   1.00 60.61  ? 76  ASP A C    1 
ATOM   1202 O O    . ASP A 1 76  ? -24.182 20.053 3.428   1.00 59.50  ? 76  ASP A O    1 
ATOM   1203 C CB   . ASP A 1 76  ? -24.060 22.295 0.960   1.00 56.59  ? 76  ASP A CB   1 
ATOM   1204 C CG   . ASP A 1 76  ? -24.024 22.283 -0.554  1.00 55.82  ? 76  ASP A CG   1 
ATOM   1205 O OD1  . ASP A 1 76  ? -24.349 21.241 -1.146  1.00 59.55  ? 76  ASP A OD1  1 
ATOM   1206 O OD2  . ASP A 1 76  ? -23.664 23.324 -1.125  1.00 59.27  ? 76  ASP A OD2  1 
ATOM   1207 H H    . ASP A 1 76  ? -26.537 22.569 1.124   1.00 71.85  ? 76  ASP A H    1 
ATOM   1208 H HA   . ASP A 1 76  ? -24.931 20.429 1.137   1.00 70.95  ? 76  ASP A HA   1 
ATOM   1209 H HB2  . ASP A 1 76  ? -24.315 23.195 1.250   1.00 67.96  ? 76  ASP A HB2  1 
ATOM   1210 H HB3  . ASP A 1 76  ? -23.158 22.112 1.291   1.00 67.96  ? 76  ASP A HB3  1 
ATOM   1211 N N    . LYS A 1 77  ? -25.097 22.049 3.878   1.00 30.00  ? 77  LYS A N    1 
ATOM   1212 C CA   . LYS A 1 77  ? -24.877 21.904 5.326   1.00 30.00  ? 77  LYS A CA   1 
ATOM   1213 C C    . LYS A 1 77  ? -25.709 20.747 5.889   1.00 30.00  ? 77  LYS A C    1 
ATOM   1214 O O    . LYS A 1 77  ? -25.204 20.075 6.752   1.00 30.00  ? 77  LYS A O    1 
ATOM   1215 C CB   . LYS A 1 77  ? -25.151 23.233 6.026   1.00 30.00  ? 77  LYS A CB   1 
ATOM   1216 C CG   . LYS A 1 77  ? -24.007 24.235 5.992   1.00 30.00  ? 77  LYS A CG   1 
ATOM   1217 C CD   . LYS A 1 77  ? -24.404 25.550 5.363   1.00 30.00  ? 77  LYS A CD   1 
ATOM   1218 C CE   . LYS A 1 77  ? -23.241 26.493 5.149   1.00 30.00  ? 77  LYS A CE   1 
ATOM   1219 N NZ   . LYS A 1 77  ? -23.125 27.473 6.253   1.00 30.00  ? 77  LYS A NZ   1 
ATOM   1220 N N    . VAL A 1 78  ? -26.930 20.541 5.430   1.00 55.24  ? 78  VAL A N    1 
ATOM   1221 C CA   . VAL A 1 78  ? -27.797 19.464 5.947   1.00 56.02  ? 78  VAL A CA   1 
ATOM   1222 C C    . VAL A 1 78  ? -27.035 18.179 5.669   1.00 65.88  ? 78  VAL A C    1 
ATOM   1223 O O    . VAL A 1 78  ? -26.876 17.399 6.593   1.00 68.06  ? 78  VAL A O    1 
ATOM   1224 C CB   . VAL A 1 78  ? -29.206 19.448 5.336   1.00 30.00  ? 78  VAL A CB   1 
ATOM   1225 C CG1  . VAL A 1 78  ? -29.895 18.117 5.561   1.00 30.00  ? 78  VAL A CG1  1 
ATOM   1226 C CG2  . VAL A 1 78  ? -30.054 20.586 5.866   1.00 30.00  ? 78  VAL A CG2  1 
ATOM   1227 H H    . VAL A 1 78  ? -27.303 21.034 4.762   1.00 66.34  ? 78  VAL A H    1 
ATOM   1228 H HA   . VAL A 1 78  ? -27.879 19.571 6.911   1.00 67.28  ? 78  VAL A HA   1 
ATOM   1229 N N    . TYR A 1 79  ? -26.536 18.017 4.456   1.00 67.69  ? 79  TYR A N    1 
ATOM   1230 C CA   . TYR A 1 79  ? -25.719 16.836 4.092   1.00 71.03  ? 79  TYR A CA   1 
ATOM   1231 C C    . TYR A 1 79  ? -24.626 16.692 5.126   1.00 66.72  ? 79  TYR A C    1 
ATOM   1232 O O    . TYR A 1 79  ? -24.571 15.678 5.781   1.00 74.08  ? 79  TYR A O    1 
ATOM   1233 C CB   . TYR A 1 79  ? -25.139 16.945 2.678   1.00 68.90  ? 79  TYR A CB   1 
ATOM   1234 C CG   . TYR A 1 79  ? -26.137 17.127 1.548   1.00 68.87  ? 79  TYR A CG   1 
ATOM   1235 C CD1  . TYR A 1 79  ? -27.439 16.649 1.628   1.00 65.29  ? 79  TYR A CD1  1 
ATOM   1236 C CD2  . TYR A 1 79  ? -25.751 17.771 0.385   1.00 76.00  ? 79  TYR A CD2  1 
ATOM   1237 C CE1  . TYR A 1 79  ? -28.327 16.820 0.581   1.00 69.39  ? 79  TYR A CE1  1 
ATOM   1238 C CE2  . TYR A 1 79  ? -26.626 17.945 -0.670  1.00 72.50  ? 79  TYR A CE2  1 
ATOM   1239 C CZ   . TYR A 1 79  ? -27.917 17.471 -0.567  1.00 72.25  ? 79  TYR A CZ   1 
ATOM   1240 O OH   . TYR A 1 79  ? -28.752 17.660 -1.619  1.00 70.41  ? 79  TYR A OH   1 
ATOM   1241 H H    . TYR A 1 79  ? -26.656 18.637 3.812   1.00 81.28  ? 79  TYR A H    1 
ATOM   1242 H HA   . TYR A 1 79  ? -26.297 16.030 4.135   1.00 85.29  ? 79  TYR A HA   1 
ATOM   1243 H HB2  . TYR A 1 79  ? -24.510 17.694 2.660   1.00 82.74  ? 79  TYR A HB2  1 
ATOM   1244 H HB3  . TYR A 1 79  ? -24.619 16.130 2.503   1.00 82.74  ? 79  TYR A HB3  1 
ATOM   1245 H HD1  . TYR A 1 79  ? -27.726 16.202 2.407   1.00 78.40  ? 79  TYR A HD1  1 
ATOM   1246 H HD2  . TYR A 1 79  ? -24.871 18.103 0.311   1.00 91.25  ? 79  TYR A HD2  1 
ATOM   1247 H HE1  . TYR A 1 79  ? -29.209 16.493 0.650   1.00 83.32  ? 79  TYR A HE1  1 
ATOM   1248 H HE2  . TYR A 1 79  ? -26.348 18.393 -1.449  1.00 87.05  ? 79  TYR A HE2  1 
ATOM   1249 H HH   . TYR A 1 79  ? -28.877 16.914 -2.022  1.00 84.54  ? 79  TYR A HH   1 
ATOM   1250 N N    . GLU A 1 80  ? -23.840 17.716 5.346   1.00 65.84  ? 80  GLU A N    1 
ATOM   1251 C CA   . GLU A 1 80  ? -22.693 17.619 6.264   1.00 72.90  ? 80  GLU A CA   1 
ATOM   1252 C C    . GLU A 1 80  ? -23.131 17.165 7.645   1.00 68.67  ? 80  GLU A C    1 
ATOM   1253 O O    . GLU A 1 80  ? -22.508 16.250 8.161   1.00 67.84  ? 80  GLU A O    1 
ATOM   1254 C CB   . GLU A 1 80  ? -22.016 18.978 6.393   1.00 77.94  ? 80  GLU A CB   1 
ATOM   1255 C CG   . GLU A 1 80  ? -21.103 19.313 5.235   1.00 84.41  ? 80  GLU A CG   1 
ATOM   1256 C CD   . GLU A 1 80  ? -20.069 20.386 5.532   1.00 87.74  ? 80  GLU A CD   1 
ATOM   1257 O OE1  . GLU A 1 80  ? -20.419 21.380 6.192   1.00 90.69  ? 80  GLU A OE1  1 
ATOM   1258 O OE2  . GLU A 1 80  ? -18.914 20.224 5.100   1.00 85.93  ? 80  GLU A OE2  1 
ATOM   1259 H H    . GLU A 1 80  ? -23.960 18.534 4.964   1.00 79.06  ? 80  GLU A H    1 
ATOM   1260 H HA   . GLU A 1 80  ? -22.051 16.970 5.900   1.00 87.53  ? 80  GLU A HA   1 
ATOM   1261 H HB2  . GLU A 1 80  ? -22.706 19.665 6.461   1.00 93.58  ? 80  GLU A HB2  1 
ATOM   1262 H HB3  . GLU A 1 80  ? -21.497 18.989 7.223   1.00 93.58  ? 80  GLU A HB3  1 
ATOM   1263 H HG2  . GLU A 1 80  ? -20.634 18.498 4.957   1.00 101.34 ? 80  GLU A HG2  1 
ATOM   1264 H HG3  . GLU A 1 80  ? -21.650 19.611 4.479   1.00 101.34 ? 80  GLU A HG3  1 
ATOM   1265 N N    . ILE A 1 81  ? -24.108 17.818 8.237   1.00 68.63  ? 81  ILE A N    1 
ATOM   1266 C CA   . ILE A 1 81  ? -24.559 17.553 9.629   1.00 68.89  ? 81  ILE A CA   1 
ATOM   1267 C C    . ILE A 1 81  ? -25.007 16.102 9.728   1.00 73.94  ? 81  ILE A C    1 
ATOM   1268 O O    . ILE A 1 81  ? -24.706 15.496 10.735  1.00 71.85  ? 81  ILE A O    1 
ATOM   1269 C CB   . ILE A 1 81  ? -25.669 18.541 9.995   1.00 62.07  ? 81  ILE A CB   1 
ATOM   1270 C CG1  . ILE A 1 81  ? -25.119 19.961 10.135  1.00 76.05  ? 81  ILE A CG1  1 
ATOM   1271 C CG2  . ILE A 1 81  ? -26.420 18.102 11.236  1.00 65.66  ? 81  ILE A CG2  1 
ATOM   1272 C CD1  . ILE A 1 81  ? -24.289 20.193 11.377  1.00 88.89  ? 81  ILE A CD1  1 
ATOM   1273 H H    . ILE A 1 81  ? -24.596 18.454 7.812   1.00 82.40  ? 81  ILE A H    1 
ATOM   1274 H HA   . ILE A 1 81  ? -23.808 17.688 10.229  1.00 82.72  ? 81  ILE A HA   1 
ATOM   1275 H HB   . ILE A 1 81  ? -26.313 18.548 9.244   1.00 74.53  ? 81  ILE A HB   1 
ATOM   1276 H HG12 . ILE A 1 81  ? -24.568 20.163 9.351   1.00 91.32  ? 81  ILE A HG12 1 
ATOM   1277 H HG13 . ILE A 1 81  ? -25.872 20.588 10.140  1.00 91.32  ? 81  ILE A HG13 1 
ATOM   1278 H HG21 . ILE A 1 81  ? -26.891 18.863 11.615  1.00 78.84  ? 81  ILE A HG21 1 
ATOM   1279 H HG22 . ILE A 1 81  ? -27.063 17.410 11.002  1.00 78.84  ? 81  ILE A HG22 1 
ATOM   1280 H HG23 . ILE A 1 81  ? -25.793 17.753 11.892  1.00 78.84  ? 81  ILE A HG23 1 
ATOM   1281 H HD11 . ILE A 1 81  ? -24.877 20.364 12.133  1.00 106.71 ? 81  ILE A HD11 1 
ATOM   1282 H HD12 . ILE A 1 81  ? -23.708 20.960 11.240  1.00 106.71 ? 81  ILE A HD12 1 
ATOM   1283 H HD13 . ILE A 1 81  ? -23.747 19.407 11.560  1.00 106.71 ? 81  ILE A HD13 1 
ATOM   1284 N N    . LEU A 1 82  ? -25.630 15.572 8.688   1.00 67.57  ? 82  LEU A N    1 
ATOM   1285 C CA   . LEU A 1 82  ? -26.100 14.168 8.645   1.00 75.32  ? 82  LEU A CA   1 
ATOM   1286 C C    . LEU A 1 82  ? -25.026 13.284 8.006   1.00 76.07  ? 82  LEU A C    1 
ATOM   1287 O O    . LEU A 1 82  ? -25.381 12.215 7.527   1.00 80.82  ? 82  LEU A O    1 
ATOM   1288 C CB   . LEU A 1 82  ? -27.403 14.110 7.850   1.00 66.98  ? 82  LEU A CB   1 
ATOM   1289 C CG   . LEU A 1 82  ? -28.539 15.001 8.339   1.00 70.50  ? 82  LEU A CG   1 
ATOM   1290 C CD1  . LEU A 1 82  ? -29.832 14.618 7.648   1.00 69.23  ? 82  LEU A CD1  1 
ATOM   1291 C CD2  . LEU A 1 82  ? -28.694 14.920 9.843   1.00 76.83  ? 82  LEU A CD2  1 
ATOM   1292 H H    . LEU A 1 82  ? -25.806 16.043 7.928   1.00 81.14  ? 82  LEU A H    1 
ATOM   1293 H HA   . LEU A 1 82  ? -26.258 13.857 9.562   1.00 90.44  ? 82  LEU A HA   1 
ATOM   1294 H HB2  . LEU A 1 82  ? -27.202 14.359 6.927   1.00 80.43  ? 82  LEU A HB2  1 
ATOM   1295 H HB3  . LEU A 1 82  ? -27.723 13.187 7.844   1.00 80.43  ? 82  LEU A HB3  1 
ATOM   1296 H HG   . LEU A 1 82  ? -28.327 15.934 8.101   1.00 84.65  ? 82  LEU A HG   1 
ATOM   1297 H HD11 . LEU A 1 82  ? -29.667 14.498 6.697   1.00 83.12  ? 82  LEU A HD11 1 
ATOM   1298 H HD12 . LEU A 1 82  ? -30.491 15.322 7.777   1.00 83.12  ? 82  LEU A HD12 1 
ATOM   1299 H HD13 . LEU A 1 82  ? -30.166 13.787 8.027   1.00 83.12  ? 82  LEU A HD13 1 
ATOM   1300 H HD21 . LEU A 1 82  ? -29.590 15.203 10.091  1.00 92.24  ? 82  LEU A HD21 1 
ATOM   1301 H HD22 . LEU A 1 82  ? -28.552 14.003 10.134  1.00 92.24  ? 82  LEU A HD22 1 
ATOM   1302 H HD23 . LEU A 1 82  ? -28.040 15.501 10.270  1.00 92.24  ? 82  LEU A HD23 1 
ATOM   1303 N N    . LYS A 1 83  ? -23.764 13.692 8.031   1.00 76.77  ? 83  LYS A N    1 
ATOM   1304 C CA   . LYS A 1 83  ? -22.630 12.919 7.479   1.00 77.55  ? 83  LYS A CA   1 
ATOM   1305 C C    . LYS A 1 83  ? -23.146 12.073 6.333   1.00 83.42  ? 83  LYS A C    1 
ATOM   1306 O O    . LYS A 1 83  ? -23.081 10.859 6.446   1.00 96.55  ? 83  LYS A O    1 
ATOM   1307 C CB   . LYS A 1 83  ? -21.966 12.048 8.540   1.00 30.00  ? 83  LYS A CB   1 
ATOM   1308 H H    . LYS A 1 83  ? -23.514 14.479 8.391   1.00 92.17  ? 83  LYS A H    1 
ATOM   1309 H HA   . LYS A 1 83  ? -21.966 13.555 7.125   1.00 93.11  ? 83  LYS A HA   1 
ATOM   1310 N N    . ILE A 1 84  ? -23.604 12.706 5.275   1.00 82.72  ? 84  ILE A N    1 
ATOM   1311 C CA   . ILE A 1 84  ? -24.091 12.007 4.073   1.00 91.14  ? 84  ILE A CA   1 
ATOM   1312 C C    . ILE A 1 84  ? -22.936 12.049 3.073   1.00 102.73 ? 84  ILE A C    1 
ATOM   1313 O O    . ILE A 1 84  ? -22.216 13.045 3.092   1.00 93.63  ? 84  ILE A O    1 
ATOM   1314 C CB   . ILE A 1 84  ? -25.395 12.655 3.560   1.00 87.51  ? 84  ILE A CB   1 
ATOM   1315 C CG1  . ILE A 1 84  ? -26.409 12.878 4.683   1.00 80.27  ? 84  ILE A CG1  1 
ATOM   1316 C CG2  . ILE A 1 84  ? -26.004 11.847 2.425   1.00 84.68  ? 84  ILE A CG2  1 
ATOM   1317 C CD1  . ILE A 1 84  ? -27.718 13.463 4.226   1.00 72.90  ? 84  ILE A CD1  1 
ATOM   1318 H H    . ILE A 1 84  ? -23.654 13.615 5.223   1.00 99.32  ? 84  ILE A H    1 
ATOM   1319 H HA   . ILE A 1 84  ? -24.279 11.082 4.295   1.00 109.42 ? 84  ILE A HA   1 
ATOM   1320 H HB   . ILE A 1 84  ? -25.158 13.545 3.200   1.00 105.07 ? 84  ILE A HB   1 
ATOM   1321 H HG12 . ILE A 1 84  ? -26.583 12.021 5.125   1.00 96.38  ? 84  ILE A HG12 1 
ATOM   1322 H HG13 . ILE A 1 84  ? -26.019 13.485 5.343   1.00 96.38  ? 84  ILE A HG13 1 
ATOM   1323 H HG21 . ILE A 1 84  ? -26.298 12.448 1.719   1.00 101.67 ? 84  ILE A HG21 1 
ATOM   1324 H HG22 . ILE A 1 84  ? -26.767 11.343 2.756   1.00 101.67 ? 84  ILE A HG22 1 
ATOM   1325 H HG23 . ILE A 1 84  ? -25.346 11.230 2.068   1.00 101.67 ? 84  ILE A HG23 1 
ATOM   1326 H HD11 . ILE A 1 84  ? -28.130 13.950 4.961   1.00 87.53  ? 84  ILE A HD11 1 
ATOM   1327 H HD12 . ILE A 1 84  ? -27.561 14.073 3.484   1.00 87.53  ? 84  ILE A HD12 1 
ATOM   1328 H HD13 . ILE A 1 84  ? -28.313 12.749 3.939   1.00 87.53  ? 84  ILE A HD13 1 
ATOM   1329 N N    . ASN A 1 85  ? -22.766 11.011 2.248   1.00 105.53 ? 85  ASN A N    1 
ATOM   1330 C CA   . ASN A 1 85  ? -21.720 10.892 1.228   1.00 105.88 ? 85  ASN A CA   1 
ATOM   1331 C C    . ASN A 1 85  ? -22.132 9.850  0.207   1.00 103.19 ? 85  ASN A C    1 
ATOM   1332 O O    . ASN A 1 85  ? -23.265 9.871  -0.277  1.00 95.63  ? 85  ASN A O    1 
ATOM   1333 C CB   . ASN A 1 85  ? -20.380 10.549 1.890   1.00 116.13 ? 85  ASN A CB   1 
ATOM   1334 C CG   . ASN A 1 85  ? -20.483 9.379  2.855   1.00 130.24 ? 85  ASN A CG   1 
ATOM   1335 O OD1  . ASN A 1 85  ? -21.321 8.490  2.701   1.00 137.41 ? 85  ASN A OD1  1 
ATOM   1336 N ND2  . ASN A 1 85  ? -19.637 9.394  3.883   1.00 123.84 ? 85  ASN A ND2  1 
ATOM   1337 H H    . ASN A 1 85  ? -23.318 10.352 2.253   1.00 126.68 ? 85  ASN A H    1 
ATOM   1338 H HA   . ASN A 1 85  ? -21.589 11.731 0.758   1.00 127.10 ? 85  ASN A HA   1 
ATOM   1339 H HB2  . ASN A 1 85  ? -19.738 10.315 1.202   1.00 139.41 ? 85  ASN A HB2  1 
ATOM   1340 H HB3  . ASN A 1 85  ? -20.067 11.321 2.387   1.00 139.41 ? 85  ASN A HB3  1 
ATOM   1341 H HD21 . ASN A 1 85  ? -19.077 10.042 3.969   1.00 148.66 ? 85  ASN A HD21 1 
ATOM   1342 H HD22 . ASN A 1 85  ? -19.650 8.758  4.461   1.00 148.66 ? 85  ASN A HD22 1 
ATOM   1343 N N    . ASP A 1 97  ? -27.255 6.657  3.418   1.00 70.27  ? 97  ASP A N    1 
ATOM   1344 C CA   . ASP A 1 97  ? -27.180 7.737  2.410   1.00 73.01  ? 97  ASP A CA   1 
ATOM   1345 C C    . ASP A 1 97  ? -28.512 8.483  2.420   1.00 71.68  ? 97  ASP A C    1 
ATOM   1346 O O    . ASP A 1 97  ? -29.153 8.492  3.473   1.00 61.16  ? 97  ASP A O    1 
ATOM   1347 C CB   . ASP A 1 97  ? -26.808 7.144  1.053   1.00 84.14  ? 97  ASP A CB   1 
ATOM   1348 C CG   . ASP A 1 97  ? -25.922 8.046  0.217   1.00 98.03  ? 97  ASP A CG   1 
ATOM   1349 O OD1  . ASP A 1 97  ? -26.038 9.276  0.352   1.00 104.06 ? 97  ASP A OD1  1 
ATOM   1350 O OD2  . ASP A 1 97  ? -25.129 7.506  -0.568  1.00 104.62 ? 97  ASP A OD2  1 
ATOM   1351 H H    . ASP A 1 97  ? -27.882 6.861  4.048   1.00 84.37  ? 97  ASP A H    1 
ATOM   1352 H HA   . ASP A 1 97  ? -26.470 8.361  2.686   1.00 87.67  ? 97  ASP A HA   1 
ATOM   1353 H HB2  . ASP A 1 97  ? -26.329 6.304  1.201   1.00 101.02 ? 97  ASP A HB2  1 
ATOM   1354 H HB3  . ASP A 1 97  ? -27.621 6.943  0.547   1.00 101.02 ? 97  ASP A HB3  1 
ATOM   1355 N N    . ALA A 1 98  ? -28.922 9.046  1.294   1.00 67.39  ? 98  ALA A N    1 
ATOM   1356 C CA   . ALA A 1 98  ? -30.121 9.883  1.202   1.00 60.65  ? 98  ALA A CA   1 
ATOM   1357 C C    . ALA A 1 98  ? -30.521 10.129 -0.231  1.00 53.14  ? 98  ALA A C    1 
ATOM   1358 O O    . ALA A 1 98  ? -29.635 10.237 -1.063  1.00 53.12  ? 98  ALA A O    1 
ATOM   1359 C CB   . ALA A 1 98  ? -29.857 11.204 1.838   1.00 59.95  ? 98  ALA A CB   1 
ATOM   1360 H H    . ALA A 1 98  ? -28.490 8.989  0.501   1.00 80.92  ? 98  ALA A H    1 
ATOM   1361 H HA   . ALA A 1 98  ? -30.850 9.433  1.668   1.00 72.83  ? 98  ALA A HA   1 
ATOM   1362 H HB1  . ALA A 1 98  ? -29.715 11.086 2.792   1.00 71.99  ? 98  ALA A HB1  1 
ATOM   1363 H HB2  . ALA A 1 98  ? -29.065 11.603 1.442   1.00 71.99  ? 98  ALA A HB2  1 
ATOM   1364 H HB3  . ALA A 1 98  ? -30.620 11.790 1.695   1.00 71.99  ? 98  ALA A HB3  1 
ATOM   1365 N N    . VAL A 1 99  ? -31.808 10.150 -0.474  1.00 52.11  ? 99  VAL A N    1 
ATOM   1366 C CA   . VAL A 1 99  ? -32.383 10.532 -1.777  1.00 50.80  ? 99  VAL A CA   1 
ATOM   1367 C C    . VAL A 1 99  ? -32.687 12.021 -1.602  1.00 54.61  ? 99  VAL A C    1 
ATOM   1368 O O    . VAL A 1 99  ? -32.879 12.401 -0.464  1.00 46.95  ? 99  VAL A O    1 
ATOM   1369 C CB   . VAL A 1 99  ? -33.608 9.665  -2.089  1.00 52.42  ? 99  VAL A CB   1 
ATOM   1370 C CG1  . VAL A 1 99  ? -33.264 8.188  -2.050  1.00 57.23  ? 99  VAL A CG1  1 
ATOM   1371 C CG2  . VAL A 1 99  ? -34.783 9.939  -1.163  1.00 52.18  ? 99  VAL A CG2  1 
ATOM   1372 H H    . VAL A 1 99  ? -32.426 9.944  0.159   1.00 62.59  ? 99  VAL A H    1 
ATOM   1373 H HA   . VAL A 1 99  ? -31.719 10.416 -2.476  1.00 61.01  ? 99  VAL A HA   1 
ATOM   1374 H HB   . VAL A 1 99  ? -33.897 9.882  -3.009  1.00 62.95  ? 99  VAL A HB   1 
ATOM   1375 H HG11 . VAL A 1 99  ? -33.898 7.690  -2.597  1.00 68.72  ? 99  VAL A HG11 1 
ATOM   1376 H HG12 . VAL A 1 99  ? -32.364 8.054  -2.392  1.00 68.72  ? 99  VAL A HG12 1 
ATOM   1377 H HG13 . VAL A 1 99  ? -33.312 7.869  -1.131  1.00 68.72  ? 99  VAL A HG13 1 
ATOM   1378 H HG21 . VAL A 1 99  ? -35.508 9.324  -1.373  1.00 62.67  ? 99  VAL A HG21 1 
ATOM   1379 H HG22 . VAL A 1 99  ? -34.509 9.809  -0.240  1.00 62.67  ? 99  VAL A HG22 1 
ATOM   1380 H HG23 . VAL A 1 99  ? -35.092 10.852 -1.283  1.00 62.67  ? 99  VAL A HG23 1 
ATOM   1381 N N    . VAL A 1 100 ? -32.631 12.837 -2.648  1.00 57.36  ? 100 VAL A N    1 
ATOM   1382 C CA   . VAL A 1 100 ? -32.841 14.305 -2.532  1.00 47.53  ? 100 VAL A CA   1 
ATOM   1383 C C    . VAL A 1 100 ? -33.625 14.884 -3.700  1.00 45.77  ? 100 VAL A C    1 
ATOM   1384 O O    . VAL A 1 100 ? -33.607 14.286 -4.769  1.00 43.40  ? 100 VAL A O    1 
ATOM   1385 C CB   . VAL A 1 100 ? -31.521 15.073 -2.363  1.00 46.36  ? 100 VAL A CB   1 
ATOM   1386 C CG1  . VAL A 1 100 ? -31.760 16.560 -2.181  1.00 47.30  ? 100 VAL A CG1  1 
ATOM   1387 C CG2  . VAL A 1 100 ? -30.701 14.548 -1.201  1.00 52.93  ? 100 VAL A CG2  1 
ATOM   1388 H H    . VAL A 1 100 ? -32.470 12.549 -3.495  1.00 68.88  ? 100 VAL A H    1 
ATOM   1389 H HA   . VAL A 1 100 ? -33.363 14.456 -1.741  1.00 57.08  ? 100 VAL A HA   1 
ATOM   1390 H HB   . VAL A 1 100 ? -30.995 14.947 -3.188  1.00 55.69  ? 100 VAL A HB   1 
ATOM   1391 H HG11 . VAL A 1 100 ? -31.725 17.008 -3.043  1.00 56.81  ? 100 VAL A HG11 1 
ATOM   1392 H HG12 . VAL A 1 100 ? -32.628 16.704 -1.773  1.00 56.81  ? 100 VAL A HG12 1 
ATOM   1393 H HG13 . VAL A 1 100 ? -31.081 16.924 -1.597  1.00 56.81  ? 100 VAL A HG13 1 
ATOM   1394 H HG21 . VAL A 1 100 ? -31.245 14.550 -0.394  1.00 63.57  ? 100 VAL A HG21 1 
ATOM   1395 H HG22 . VAL A 1 100 ? -30.402 13.643 -1.391  1.00 63.57  ? 100 VAL A HG22 1 
ATOM   1396 H HG23 . VAL A 1 100 ? -29.928 15.121 -1.068  1.00 63.57  ? 100 VAL A HG23 1 
ATOM   1397 N N    . ALA A 1 101 ? -34.345 15.967 -3.452  1.00 46.22  ? 101 ALA A N    1 
ATOM   1398 C CA   . ALA A 1 101 ? -35.015 16.762 -4.477  1.00 37.99  ? 101 ALA A CA   1 
ATOM   1399 C C    . ALA A 1 101 ? -34.880 18.209 -4.034  1.00 47.52  ? 101 ALA A C    1 
ATOM   1400 O O    . ALA A 1 101 ? -34.876 18.420 -2.851  1.00 46.36  ? 101 ALA A O    1 
ATOM   1401 C CB   . ALA A 1 101 ? -36.435 16.382 -4.617  1.00 46.58  ? 101 ALA A CB   1 
ATOM   1402 H H    . ALA A 1 101 ? -34.519 16.270 -2.611  1.00 55.52  ? 101 ALA A H    1 
ATOM   1403 H HA   . ALA A 1 101 ? -34.555 16.645 -5.338  1.00 45.64  ? 101 ALA A HA   1 
ATOM   1404 H HB1  . ALA A 1 101 ? -36.780 16.095 -3.754  1.00 55.94  ? 101 ALA A HB1  1 
ATOM   1405 H HB2  . ALA A 1 101 ? -36.518 15.656 -5.257  1.00 55.94  ? 101 ALA A HB2  1 
ATOM   1406 H HB3  . ALA A 1 101 ? -36.946 17.148 -4.928  1.00 55.94  ? 101 ALA A HB3  1 
ATOM   1407 N N    . ASP A 1 102 ? -34.704 19.141 -4.956  1.00 43.80  ? 102 ASP A N    1 
ATOM   1408 C CA   . ASP A 1 102 ? -34.601 20.587 -4.679  1.00 38.68  ? 102 ASP A CA   1 
ATOM   1409 C C    . ASP A 1 102 ? -35.539 21.286 -5.651  1.00 39.71  ? 102 ASP A C    1 
ATOM   1410 O O    . ASP A 1 102 ? -35.216 21.337 -6.822  1.00 42.71  ? 102 ASP A O    1 
ATOM   1411 C CB   . ASP A 1 102 ? -33.159 21.051 -4.770  1.00 37.40  ? 102 ASP A CB   1 
ATOM   1412 C CG   . ASP A 1 102 ? -32.958 22.526 -4.522  1.00 39.42  ? 102 ASP A CG   1 
ATOM   1413 O OD1  . ASP A 1 102 ? -33.874 23.157 -4.021  1.00 46.01  ? 102 ASP A OD1  1 
ATOM   1414 O OD2  . ASP A 1 102 ? -31.883 23.009 -4.831  1.00 39.97  ? 102 ASP A OD2  1 
ATOM   1415 H H    . ASP A 1 102 ? -34.641 18.940 -5.841  1.00 52.61  ? 102 ASP A H    1 
ATOM   1416 H HA   . ASP A 1 102 ? -34.925 20.755 -3.762  1.00 46.47  ? 102 ASP A HA   1 
ATOM   1417 H HB2  . ASP A 1 102 ? -32.636 20.559 -4.105  1.00 44.93  ? 102 ASP A HB2  1 
ATOM   1418 H HB3  . ASP A 1 102 ? -32.808 20.833 -5.656  1.00 44.93  ? 102 ASP A HB3  1 
ATOM   1419 N N    . LEU A 1 103 ? -36.650 21.800 -5.165  1.00 40.93  ? 103 LEU A N    1 
ATOM   1420 C CA   . LEU A 1 103 ? -37.653 22.494 -5.981  1.00 39.16  ? 103 LEU A CA   1 
ATOM   1421 C C    . LEU A 1 103 ? -37.453 23.996 -5.794  1.00 38.39  ? 103 LEU A C    1 
ATOM   1422 O O    . LEU A 1 103 ? -38.179 24.744 -6.415  1.00 40.19  ? 103 LEU A O    1 
ATOM   1423 C CB   . LEU A 1 103 ? -39.023 21.992 -5.542  1.00 39.94  ? 103 LEU A CB   1 
ATOM   1424 C CG   . LEU A 1 103 ? -39.596 20.810 -6.319  1.00 45.46  ? 103 LEU A CG   1 
ATOM   1425 C CD1  . LEU A 1 103 ? -38.810 19.540 -6.051  1.00 47.49  ? 103 LEU A CD1  1 
ATOM   1426 C CD2  . LEU A 1 103 ? -41.065 20.605 -5.977  1.00 48.22  ? 103 LEU A CD2  1 
ATOM   1427 H H    . LEU A 1 103 ? -36.864 21.753 -4.280  1.00 49.17  ? 103 LEU A H    1 
ATOM   1428 H HA   . LEU A 1 103 ? -37.513 22.269 -6.927  1.00 47.04  ? 103 LEU A HA   1 
ATOM   1429 H HB2  . LEU A 1 103 ? -38.965 21.738 -4.599  1.00 47.97  ? 103 LEU A HB2  1 
ATOM   1430 H HB3  . LEU A 1 103 ? -39.657 22.734 -5.603  1.00 47.97  ? 103 LEU A HB3  1 
ATOM   1431 H HG   . LEU A 1 103 ? -39.531 21.015 -7.283  1.00 54.60  ? 103 LEU A HG   1 
ATOM   1432 H HD11 . LEU A 1 103 ? -39.364 18.767 -6.260  1.00 57.04  ? 103 LEU A HD11 1 
ATOM   1433 H HD12 . LEU A 1 103 ? -38.012 19.528 -6.607  1.00 57.04  ? 103 LEU A HD12 1 
ATOM   1434 H HD13 . LEU A 1 103 ? -38.552 19.510 -5.113  1.00 57.04  ? 103 LEU A HD13 1 
ATOM   1435 H HD21 . LEU A 1 103 ? -41.407 19.836 -6.465  1.00 57.91  ? 103 LEU A HD21 1 
ATOM   1436 H HD22 . LEU A 1 103 ? -41.156 20.448 -5.021  1.00 57.91  ? 103 LEU A HD22 1 
ATOM   1437 H HD23 . LEU A 1 103 ? -41.571 21.398 -6.226  1.00 57.91  ? 103 LEU A HD23 1 
ATOM   1438 N N    . SER A 1 104 ? -36.440 24.398 -5.044  1.00 38.90  ? 104 SER A N    1 
ATOM   1439 C CA   . SER A 1 104 ? -36.109 25.810 -4.776  1.00 37.31  ? 104 SER A CA   1 
ATOM   1440 C C    . SER A 1 104 ? -35.688 26.550 -6.030  1.00 41.38  ? 104 SER A C    1 
ATOM   1441 O O    . SER A 1 104 ? -35.356 25.895 -7.011  1.00 38.29  ? 104 SER A O    1 
ATOM   1442 C CB   . SER A 1 104 ? -34.997 25.940 -3.813  1.00 34.11  ? 104 SER A CB   1 
ATOM   1443 O OG   . SER A 1 104 ? -33.745 25.923 -4.460  1.00 39.61  ? 104 SER A OG   1 
ATOM   1444 H H    . SER A 1 104 ? -35.873 23.827 -4.621  1.00 46.73  ? 104 SER A H    1 
ATOM   1445 H HA   . SER A 1 104 ? -36.915 26.256 -4.399  1.00 44.83  ? 104 SER A HA   1 
ATOM   1446 H HB2  . SER A 1 104 ? -35.095 26.786 -3.322  1.00 40.99  ? 104 SER A HB2  1 
ATOM   1447 H HB3  . SER A 1 104 ? -35.045 25.208 -3.160  1.00 40.99  ? 104 SER A HB3  1 
ATOM   1448 H HG   . SER A 1 104 ? -33.633 25.169 -4.820  1.00 47.59  ? 104 SER A HG   1 
ATOM   1449 N N    . ALA A 1 105 ? -35.700 27.867 -5.966  1.00 39.09  ? 105 ALA A N    1 
ATOM   1450 C CA   . ALA A 1 105 ? -35.168 28.721 -7.043  1.00 41.21  ? 105 ALA A CA   1 
ATOM   1451 C C    . ALA A 1 105 ? -33.848 29.309 -6.563  1.00 39.13  ? 105 ALA A C    1 
ATOM   1452 O O    . ALA A 1 105 ? -33.757 30.474 -6.144  1.00 37.06  ? 105 ALA A O    1 
ATOM   1453 C CB   . ALA A 1 105 ? -36.145 29.798 -7.391  1.00 41.40  ? 105 ALA A CB   1 
ATOM   1454 H H    . ALA A 1 105 ? -36.026 28.311 -5.306  1.00 46.96  ? 105 ALA A H    1 
ATOM   1455 H HA   . ALA A 1 105 ? -35.018 28.186 -7.838  1.00 49.50  ? 105 ALA A HA   1 
ATOM   1456 H HB1  . ALA A 1 105 ? -36.915 29.397 -7.826  1.00 49.73  ? 105 ALA A HB1  1 
ATOM   1457 H HB2  . ALA A 1 105 ? -35.718 30.429 -7.991  1.00 49.73  ? 105 ALA A HB2  1 
ATOM   1458 H HB3  . ALA A 1 105 ? -36.422 30.248 -6.578  1.00 49.73  ? 105 ALA A HB3  1 
ATOM   1459 N N    . ARG A 1 106 ? -32.835 28.454 -6.536  1.00 37.66  ? 106 ARG A N    1 
ATOM   1460 C CA   . ARG A 1 106 ? -31.559 28.801 -5.918  1.00 47.97  ? 106 ARG A CA   1 
ATOM   1461 C C    . ARG A 1 106 ? -31.045 30.114 -6.492  1.00 37.47  ? 106 ARG A C    1 
ATOM   1462 O O    . ARG A 1 106 ? -30.975 30.276 -7.705  1.00 43.69  ? 106 ARG A O    1 
ATOM   1463 C CB   . ARG A 1 106 ? -30.555 27.671 -6.144  1.00 44.76  ? 106 ARG A CB   1 
ATOM   1464 C CG   . ARG A 1 106 ? -29.158 27.818 -5.490  1.00 60.94  ? 106 ARG A CG   1 
ATOM   1465 C CD   . ARG A 1 106 ? -28.281 26.645 -5.953  1.00 70.08  ? 106 ARG A CD   1 
ATOM   1466 N NE   . ARG A 1 106 ? -26.844 26.918 -6.007  1.00 85.16  ? 106 ARG A NE   1 
ATOM   1467 C CZ   . ARG A 1 106 ? -26.188 27.351 -7.087  1.00 85.32  ? 106 ARG A CZ   1 
ATOM   1468 N NH1  . ARG A 1 106 ? -26.832 27.587 -8.223  1.00 79.13  ? 106 ARG A NH1  1 
ATOM   1469 N NH2  . ARG A 1 106 ? -24.874 27.556 -7.033  1.00 95.90  ? 106 ARG A NH2  1 
ATOM   1470 H H    . ARG A 1 106 ? -32.859 27.662 -6.870  1.00 45.24  ? 106 ARG A H    1 
ATOM   1471 H HA   . ARG A 1 106 ? -31.667 28.912 -4.961  1.00 57.62  ? 106 ARG A HA   1 
ATOM   1472 H HB2  . ARG A 1 106 ? -30.944 26.854 -5.794  1.00 53.76  ? 106 ARG A HB2  1 
ATOM   1473 H HB3  . ARG A 1 106 ? -30.411 27.588 -7.099  1.00 53.76  ? 106 ARG A HB3  1 
ATOM   1474 H HG2  . ARG A 1 106 ? -28.747 28.652 -5.768  1.00 73.17  ? 106 ARG A HG2  1 
ATOM   1475 H HG3  . ARG A 1 106 ? -29.238 27.794 -4.524  1.00 73.17  ? 106 ARG A HG3  1 
ATOM   1476 H HD2  . ARG A 1 106 ? -28.411 25.905 -5.340  1.00 84.15  ? 106 ARG A HD2  1 
ATOM   1477 H HD3  . ARG A 1 106 ? -28.559 26.388 -6.846  1.00 84.15  ? 106 ARG A HD3  1 
ATOM   1478 H HE   . ARG A 1 106 ? -26.388 26.790 -5.289  1.00 102.24 ? 106 ARG A HE   1 
ATOM   1479 H HH11 . ARG A 1 106 ? -27.681 27.461 -8.270  1.00 95.01  ? 106 ARG A HH11 1 
ATOM   1480 H HH12 . ARG A 1 106 ? -26.400 27.865 -8.912  1.00 95.01  ? 106 ARG A HH12 1 
ATOM   1481 H HH21 . ARG A 1 106 ? -24.445 27.409 -6.302  1.00 115.13 ? 106 ARG A HH21 1 
ATOM   1482 H HH22 . ARG A 1 106 ? -24.453 27.835 -7.730  1.00 115.13 ? 106 ARG A HH22 1 
ATOM   1483 N N    . ASN A 1 107 ? -30.754 31.053 -5.604  1.00 39.96  ? 107 ASN A N    1 
ATOM   1484 C CA   . ASN A 1 107 ? -30.204 32.380 -5.882  1.00 50.19  ? 107 ASN A CA   1 
ATOM   1485 C C    . ASN A 1 107 ? -31.063 33.227 -6.815  1.00 43.52  ? 107 ASN A C    1 
ATOM   1486 O O    . ASN A 1 107 ? -30.533 34.094 -7.488  1.00 43.94  ? 107 ASN A O    1 
ATOM   1487 C CB   . ASN A 1 107 ? -28.781 32.313 -6.446  1.00 53.81  ? 107 ASN A CB   1 
ATOM   1488 C CG   . ASN A 1 107 ? -27.946 31.278 -5.763  1.00 62.08  ? 107 ASN A CG   1 
ATOM   1489 O OD1  . ASN A 1 107 ? -27.847 31.266 -4.524  1.00 63.27  ? 107 ASN A OD1  1 
ATOM   1490 N ND2  . ASN A 1 107 ? -27.340 30.383 -6.554  1.00 65.27  ? 107 ASN A ND2  1 
ATOM   1491 H H    . ASN A 1 107 ? -30.876 30.940 -4.761  1.00 48.00  ? 107 ASN A H    1 
ATOM   1492 H HA   . ASN A 1 107 ? -30.179 32.833 -5.025  1.00 60.28  ? 107 ASN A HA   1 
ATOM   1493 H HB2  . ASN A 1 107 ? -28.823 32.092 -7.390  1.00 64.63  ? 107 ASN A HB2  1 
ATOM   1494 H HB3  . ASN A 1 107 ? -28.351 33.174 -6.326  1.00 64.63  ? 107 ASN A HB3  1 
ATOM   1495 H HD21 . ASN A 1 107 ? -27.443 30.423 -7.407  1.00 78.37  ? 107 ASN A HD21 1 
ATOM   1496 H HD22 . ASN A 1 107 ? -26.849 29.767 -6.209  1.00 78.37  ? 107 ASN A HD22 1 
ATOM   1497 N N    . LYS A 1 108 ? -32.362 32.962 -6.923  1.00 38.83  ? 108 LYS A N    1 
ATOM   1498 C CA   . LYS A 1 108 ? -33.246 33.770 -7.738  1.00 39.50  ? 108 LYS A CA   1 
ATOM   1499 C C    . LYS A 1 108 ? -34.333 34.366 -6.842  1.00 43.46  ? 108 LYS A C    1 
ATOM   1500 O O    . LYS A 1 108 ? -34.717 33.779 -5.827  1.00 39.84  ? 108 LYS A O    1 
ATOM   1501 C CB   . LYS A 1 108 ? -33.880 32.925 -8.846  1.00 49.51  ? 108 LYS A CB   1 
ATOM   1502 C CG   . LYS A 1 108 ? -32.895 32.510 -9.923  1.00 55.92  ? 108 LYS A CG   1 
ATOM   1503 C CD   . LYS A 1 108 ? -33.605 31.997 -11.159 1.00 60.72  ? 108 LYS A CD   1 
ATOM   1504 C CE   . LYS A 1 108 ? -33.660 30.473 -11.224 1.00 63.10  ? 108 LYS A CE   1 
ATOM   1505 N NZ   . LYS A 1 108 ? -34.572 30.045 -12.342 1.00 66.03  ? 108 LYS A NZ   1 
ATOM   1506 H H    . LYS A 1 108 ? -32.754 32.308 -6.526  1.00 46.65  ? 108 LYS A H    1 
ATOM   1507 H HA   . LYS A 1 108 ? -32.759 34.498 -8.156  1.00 47.45  ? 108 LYS A HA   1 
ATOM   1508 H HB2  . LYS A 1 108 ? -34.250 32.119 -8.454  1.00 59.46  ? 108 LYS A HB2  1 
ATOM   1509 H HB3  . LYS A 1 108 ? -34.584 33.441 -9.270  1.00 59.46  ? 108 LYS A HB3  1 
ATOM   1510 H HG2  . LYS A 1 108 ? -32.355 33.275 -10.176 1.00 67.15  ? 108 LYS A HG2  1 
ATOM   1511 H HG3  . LYS A 1 108 ? -32.327 31.801 -9.582  1.00 67.15  ? 108 LYS A HG3  1 
ATOM   1512 H HD2  . LYS A 1 108 ? -34.516 32.330 -11.161 1.00 72.92  ? 108 LYS A HD2  1 
ATOM   1513 H HD3  . LYS A 1 108 ? -33.135 32.313 -11.947 1.00 72.92  ? 108 LYS A HD3  1 
ATOM   1514 H HE2  . LYS A 1 108 ? -32.773 30.119 -11.393 1.00 75.77  ? 108 LYS A HE2  1 
ATOM   1515 H HE3  . LYS A 1 108 ? -34.005 30.121 -10.388 1.00 75.77  ? 108 LYS A HE3  1 
ATOM   1516 H HZ1  . LYS A 1 108 ? -35.408 30.296 -12.166 1.00 79.29  ? 108 LYS A HZ1  1 
ATOM   1517 H HZ2  . LYS A 1 108 ? -34.549 29.159 -12.431 1.00 79.29  ? 108 LYS A HZ2  1 
ATOM   1518 H HZ3  . LYS A 1 108 ? -34.313 30.419 -13.106 1.00 79.29  ? 108 LYS A HZ3  1 
ATOM   1519 N N    . LEU A 1 109 ? -34.823 35.521 -7.207  1.00 41.81  ? 109 LEU A N    1 
ATOM   1520 C CA   . LEU A 1 109 ? -35.889 36.187 -6.481  1.00 39.55  ? 109 LEU A CA   1 
ATOM   1521 C C    . LEU A 1 109 ? -37.113 36.467 -7.343  1.00 45.18  ? 109 LEU A C    1 
ATOM   1522 O O    . LEU A 1 109 ? -38.264 36.319 -6.860  1.00 41.03  ? 109 LEU A O    1 
ATOM   1523 C CB   . LEU A 1 109 ? -35.321 37.495 -5.880  1.00 39.48  ? 109 LEU A CB   1 
ATOM   1524 C CG   . LEU A 1 109 ? -36.278 38.197 -4.936  1.00 45.29  ? 109 LEU A CG   1 
ATOM   1525 C CD1  . LEU A 1 109 ? -36.766 37.293 -3.777  1.00 51.66  ? 109 LEU A CD1  1 
ATOM   1526 C CD2  . LEU A 1 109 ? -35.611 39.412 -4.374  1.00 49.43  ? 109 LEU A CD2  1 
ATOM   1527 H H    . LEU A 1 109 ? -34.550 35.960 -7.894  1.00 50.22  ? 109 LEU A H    1 
ATOM   1528 H HA   . LEU A 1 109 ? -36.200 35.633 -5.748  1.00 47.51  ? 109 LEU A HA   1 
ATOM   1529 H HB2  . LEU A 1 109 ? -34.514 37.285 -5.384  1.00 47.43  ? 109 LEU A HB2  1 
ATOM   1530 H HB3  . LEU A 1 109 ? -35.115 38.106 -6.604  1.00 47.43  ? 109 LEU A HB3  1 
ATOM   1531 H HG   . LEU A 1 109 ? -37.067 38.441 -5.445  1.00 54.40  ? 109 LEU A HG   1 
ATOM   1532 H HD11 . LEU A 1 109 ? -37.292 36.566 -4.143  1.00 62.04  ? 109 LEU A HD11 1 
ATOM   1533 H HD12 . LEU A 1 109 ? -37.309 37.822 -3.172  1.00 62.04  ? 109 LEU A HD12 1 
ATOM   1534 H HD13 . LEU A 1 109 ? -35.995 36.940 -3.306  1.00 62.04  ? 109 LEU A HD13 1 
ATOM   1535 H HD21 . LEU A 1 109 ? -36.065 39.672 -3.557  1.00 59.37  ? 109 LEU A HD21 1 
ATOM   1536 H HD22 . LEU A 1 109 ? -35.663 40.130 -5.024  1.00 59.37  ? 109 LEU A HD22 1 
ATOM   1537 H HD23 . LEU A 1 109 ? -34.683 39.204 -4.185  1.00 59.37  ? 109 LEU A HD23 1 
ATOM   1538 N N    . PHE A 1 110 ? -36.904 36.859 -8.612  1.00 43.64  ? 110 PHE A N    1 
ATOM   1539 C CA   . PHE A 1 110 ? -37.981 37.161 -9.547  1.00 39.28  ? 110 PHE A CA   1 
ATOM   1540 C C    . PHE A 1 110 ? -37.773 36.369 -10.824 1.00 40.54  ? 110 PHE A C    1 
ATOM   1541 O O    . PHE A 1 110 ? -36.674 35.893 -11.114 1.00 41.78  ? 110 PHE A O    1 
ATOM   1542 C CB   . PHE A 1 110 ? -38.099 38.666 -9.856  1.00 44.40  ? 110 PHE A CB   1 
ATOM   1543 C CG   . PHE A 1 110 ? -36.845 39.316 -10.420 1.00 47.15  ? 110 PHE A CG   1 
ATOM   1544 C CD1  . PHE A 1 110 ? -36.612 39.336 -11.786 1.00 47.66  ? 110 PHE A CD1  1 
ATOM   1545 C CD2  . PHE A 1 110 ? -35.954 39.985 -9.579  1.00 46.60  ? 110 PHE A CD2  1 
ATOM   1546 C CE1  . PHE A 1 110 ? -35.481 39.995 -12.291 1.00 52.37  ? 110 PHE A CE1  1 
ATOM   1547 C CE2  . PHE A 1 110 ? -34.834 40.604 -10.067 1.00 48.07  ? 110 PHE A CE2  1 
ATOM   1548 C CZ   . PHE A 1 110 ? -34.605 40.622 -11.419 1.00 49.04  ? 110 PHE A CZ   1 
ATOM   1549 H H    . PHE A 1 110 ? -36.122 36.958 -8.955  1.00 52.42  ? 110 PHE A H    1 
ATOM   1550 H HA   . PHE A 1 110 ? -38.824 36.889 -9.154  1.00 47.19  ? 110 PHE A HA   1 
ATOM   1551 H HB2  . PHE A 1 110 ? -38.807 38.790 -10.507 1.00 53.33  ? 110 PHE A HB2  1 
ATOM   1552 H HB3  . PHE A 1 110 ? -38.320 39.131 -9.033  1.00 53.33  ? 110 PHE A HB3  1 
ATOM   1553 H HD1  . PHE A 1 110 ? -37.204 38.913 -12.366 1.00 57.24  ? 110 PHE A HD1  1 
ATOM   1554 H HD2  . PHE A 1 110 ? -36.125 40.011 -8.666  1.00 55.97  ? 110 PHE A HD2  1 
ATOM   1555 H HE1  . PHE A 1 110 ? -35.320 40.011 -13.207 1.00 62.89  ? 110 PHE A HE1  1 
ATOM   1556 H HE2  . PHE A 1 110 ? -34.232 41.009 -9.485  1.00 57.74  ? 110 PHE A HE2  1 
ATOM   1557 H HZ   . PHE A 1 110 ? -33.855 41.059 -11.754 1.00 58.90  ? 110 PHE A HZ   1 
ATOM   1558 N N    . LYS A 1 111 ? -38.869 36.206 -11.559 1.00 44.21  ? 111 LYS A N    1 
ATOM   1559 C CA   . LYS A 1 111 ? -38.954 35.282 -12.682 1.00 50.10  ? 111 LYS A CA   1 
ATOM   1560 C C    . LYS A 1 111 ? -38.635 35.938 -14.019 1.00 48.88  ? 111 LYS A C    1 
ATOM   1561 O O    . LYS A 1 111 ? -38.088 35.288 -14.911 1.00 49.57  ? 111 LYS A O    1 
ATOM   1562 C CB   . LYS A 1 111 ? -40.375 34.705 -12.767 1.00 49.36  ? 111 LYS A CB   1 
ATOM   1563 C CG   . LYS A 1 111 ? -40.870 34.021 -11.517 1.00 48.44  ? 111 LYS A CG   1 
ATOM   1564 C CD   . LYS A 1 111 ? -42.372 33.746 -11.568 1.00 45.00  ? 111 LYS A CD   1 
ATOM   1565 C CE   . LYS A 1 111 ? -42.887 33.116 -10.240 1.00 46.03  ? 111 LYS A CE   1 
ATOM   1566 N NZ   . LYS A 1 111 ? -44.293 32.553 -10.391 1.00 47.93  ? 111 LYS A NZ   1 
ATOM   1567 H H    . LYS A 1 111 ? -39.602 36.635 -11.423 1.00 53.10  ? 111 LYS A H    1 
ATOM   1568 H HA   . LYS A 1 111 ? -38.321 34.562 -12.532 1.00 60.17  ? 111 LYS A HA   1 
ATOM   1569 H HB2  . LYS A 1 111 ? -40.989 35.430 -12.963 1.00 59.28  ? 111 LYS A HB2  1 
ATOM   1570 H HB3  . LYS A 1 111 ? -40.397 34.050 -13.483 1.00 59.28  ? 111 LYS A HB3  1 
ATOM   1571 H HG2  . LYS A 1 111 ? -40.411 33.173 -11.414 1.00 58.18  ? 111 LYS A HG2  1 
ATOM   1572 H HG3  . LYS A 1 111 ? -40.693 34.590 -10.751 1.00 58.18  ? 111 LYS A HG3  1 
ATOM   1573 H HD2  . LYS A 1 111 ? -42.846 34.580 -11.712 1.00 54.05  ? 111 LYS A HD2  1 
ATOM   1574 H HD3  . LYS A 1 111 ? -42.560 33.128 -12.291 1.00 54.05  ? 111 LYS A HD3  1 
ATOM   1575 H HE2  . LYS A 1 111 ? -42.296 32.392 -9.979  1.00 55.29  ? 111 LYS A HE2  1 
ATOM   1576 H HE3  . LYS A 1 111 ? -42.904 33.796 -9.548  1.00 55.29  ? 111 LYS A HE3  1 
ATOM   1577 H HZ1  . LYS A 1 111 ? -44.323 31.989 -11.079 1.00 57.57  ? 111 LYS A HZ1  1 
ATOM   1578 H HZ2  . LYS A 1 111 ? -44.528 32.119 -9.651  1.00 57.57  ? 111 LYS A HZ2  1 
ATOM   1579 H HZ3  . LYS A 1 111 ? -44.871 33.214 -10.535 1.00 57.57  ? 111 LYS A HZ3  1 
ATOM   1580 N N    . ARG A 1 112 ? -39.001 37.203 -14.182 1.00 47.30  ? 112 ARG A N    1 
ATOM   1581 C CA   . ARG A 1 112 ? -38.719 37.965 -15.390 1.00 46.56  ? 112 ARG A CA   1 
ATOM   1582 C C    . ARG A 1 112 ? -38.617 39.436 -15.049 1.00 51.30  ? 112 ARG A C    1 
ATOM   1583 O O    . ARG A 1 112 ? -39.285 39.914 -14.121 1.00 45.20  ? 112 ARG A O    1 
ATOM   1584 C CB   . ARG A 1 112 ? -39.815 37.819 -16.464 1.00 44.48  ? 112 ARG A CB   1 
ATOM   1585 C CG   . ARG A 1 112 ? -41.330 38.088 -16.080 1.00 45.55  ? 112 ARG A CG   1 
ATOM   1586 C CD   . ARG A 1 112 ? -42.064 38.061 -17.590 1.00 49.80  ? 112 ARG A CD   1 
ATOM   1587 N NE   . ARG A 1 112 ? -41.887 39.413 -18.087 1.00 57.94  ? 112 ARG A NE   1 
ATOM   1588 C CZ   . ARG A 1 112 ? -42.802 40.364 -18.082 1.00 47.27  ? 112 ARG A CZ   1 
ATOM   1589 N NH1  . ARG A 1 112 ? -44.069 40.007 -18.087 1.00 46.70  ? 112 ARG A NH1  1 
ATOM   1590 N NH2  . ARG A 1 112 ? -42.483 41.612 -18.417 1.00 54.29  ? 112 ARG A NH2  1 
ATOM   1591 H H    . ARG A 1 112 ? -39.428 37.656 -13.588 1.00 56.81  ? 112 ARG A H    1 
ATOM   1592 H HA   . ARG A 1 112 ? -37.876 37.640 -15.743 1.00 55.93  ? 112 ARG A HA   1 
ATOM   1593 H HB2  . ARG A 1 112 ? -39.603 38.439 -17.179 1.00 53.42  ? 112 ARG A HB2  1 
ATOM   1594 H HB3  . ARG A 1 112 ? -39.778 36.907 -16.792 1.00 53.42  ? 112 ARG A HB3  1 
ATOM   1595 H HG2  . ARG A 1 112 ? -41.686 37.389 -15.510 1.00 54.71  ? 112 ARG A HG2  1 
ATOM   1596 H HG3  . ARG A 1 112 ? -41.445 38.953 -15.656 1.00 54.71  ? 112 ARG A HG3  1 
ATOM   1597 H HD2  . ARG A 1 112 ? -41.627 37.426 -18.179 1.00 59.82  ? 112 ARG A HD2  1 
ATOM   1598 H HD3  . ARG A 1 112 ? -43.008 37.850 -17.516 1.00 59.82  ? 112 ARG A HD3  1 
ATOM   1599 H HE   . ARG A 1 112 ? -41.117 39.613 -18.414 1.00 69.57  ? 112 ARG A HE   1 
ATOM   1600 H HH11 . ARG A 1 112 ? -44.282 39.174 -18.094 1.00 56.09  ? 112 ARG A HH11 1 
ATOM   1601 H HH12 . ARG A 1 112 ? -44.685 40.608 -18.084 1.00 56.09  ? 112 ARG A HH12 1 
ATOM   1602 H HH21 . ARG A 1 112 ? -41.675 41.805 -18.639 1.00 65.20  ? 112 ARG A HH21 1 
ATOM   1603 H HH22 . ARG A 1 112 ? -43.086 42.226 -18.411 1.00 65.20  ? 112 ARG A HH22 1 
ATOM   1604 N N    . GLU A 1 113 ? -37.827 40.148 -15.849 1.00 48.52  ? 113 GLU A N    1 
ATOM   1605 C CA   . GLU A 1 113 ? -37.729 41.591 -15.731 1.00 41.35  ? 113 GLU A CA   1 
ATOM   1606 C C    . GLU A 1 113 ? -39.094 42.211 -16.014 1.00 44.41  ? 113 GLU A C    1 
ATOM   1607 O O    . GLU A 1 113 ? -39.806 41.794 -16.931 1.00 42.61  ? 113 GLU A O    1 
ATOM   1608 C CB   . GLU A 1 113 ? -36.649 42.127 -16.688 1.00 49.32  ? 113 GLU A CB   1 
ATOM   1609 C CG   . GLU A 1 113 ? -35.254 41.989 -16.069 1.00 58.21  ? 113 GLU A CG   1 
ATOM   1610 C CD   . GLU A 1 113 ? -34.093 42.093 -17.070 1.00 69.83  ? 113 GLU A CD   1 
ATOM   1611 O OE1  . GLU A 1 113 ? -34.264 42.606 -18.205 1.00 70.01  ? 113 GLU A OE1  1 
ATOM   1612 O OE2  . GLU A 1 113 ? -32.984 41.668 -16.688 1.00 74.09  ? 113 GLU A OE2  1 
ATOM   1613 H H    . GLU A 1 113 ? -37.335 39.814 -16.470 1.00 58.28  ? 113 GLU A H    1 
ATOM   1614 H HA   . GLU A 1 113 ? -37.462 41.848 -14.834 1.00 49.67  ? 113 GLU A HA   1 
ATOM   1615 H HB2  . GLU A 1 113 ? -36.671 41.620 -17.515 1.00 59.24  ? 113 GLU A HB2  1 
ATOM   1616 H HB3  . GLU A 1 113 ? -36.815 43.065 -16.870 1.00 59.24  ? 113 GLU A HB3  1 
ATOM   1617 H HG2  . GLU A 1 113 ? -35.137 42.694 -15.413 1.00 69.90  ? 113 GLU A HG2  1 
ATOM   1618 H HG3  . GLU A 1 113 ? -35.192 41.122 -15.638 1.00 69.90  ? 113 GLU A HG3  1 
ATOM   1619 N N    . ARG A 1 114 ? -39.479 43.177 -15.182 1.00 39.92  ? 114 ARG A N    1 
ATOM   1620 C CA   . ARG A 1 114 ? -40.775 43.807 -15.325 1.00 49.88  ? 114 ARG A CA   1 
ATOM   1621 C C    . ARG A 1 114 ? -40.711 45.212 -14.761 1.00 41.45  ? 114 ARG A C    1 
ATOM   1622 O O    . ARG A 1 114 ? -40.008 45.468 -13.778 1.00 46.04  ? 114 ARG A O    1 
ATOM   1623 C CB   . ARG A 1 114 ? -41.860 43.014 -14.609 1.00 46.21  ? 114 ARG A CB   1 
ATOM   1624 C CG   . ARG A 1 114 ? -43.247 43.489 -14.910 1.00 52.18  ? 114 ARG A CG   1 
ATOM   1625 C CD   . ARG A 1 114 ? -44.272 42.501 -14.370 1.00 50.43  ? 114 ARG A CD   1 
ATOM   1626 N NE   . ARG A 1 114 ? -44.329 42.581 -12.913 1.00 46.44  ? 114 ARG A NE   1 
ATOM   1627 C CZ   . ARG A 1 114 ? -45.031 41.754 -12.149 1.00 47.86  ? 114 ARG A CZ   1 
ATOM   1628 N NH1  . ARG A 1 114 ? -45.720 40.780 -12.714 1.00 43.09  ? 114 ARG A NH1  1 
ATOM   1629 N NH2  . ARG A 1 114 ? -45.050 41.897 -10.820 1.00 47.68  ? 114 ARG A NH2  1 
ATOM   1630 H H    . ARG A 1 114 ? -39.004 43.479 -14.532 1.00 47.96  ? 114 ARG A H    1 
ATOM   1631 H HA   . ARG A 1 114 ? -41.002 43.864 -16.266 1.00 59.90  ? 114 ARG A HA   1 
ATOM   1632 H HB2  . ARG A 1 114 ? -41.799 42.085 -14.882 1.00 55.50  ? 114 ARG A HB2  1 
ATOM   1633 H HB3  . ARG A 1 114 ? -41.722 43.088 -13.652 1.00 55.50  ? 114 ARG A HB3  1 
ATOM   1634 H HG2  . ARG A 1 114 ? -43.395 44.350 -14.490 1.00 62.67  ? 114 ARG A HG2  1 
ATOM   1635 H HG3  . ARG A 1 114 ? -43.365 43.564 -15.870 1.00 62.67  ? 114 ARG A HG3  1 
ATOM   1636 H HD2  . ARG A 1 114 ? -45.149 42.712 -14.727 1.00 60.57  ? 114 ARG A HD2  1 
ATOM   1637 H HD3  . ARG A 1 114 ? -44.019 41.599 -14.621 1.00 60.57  ? 114 ARG A HD3  1 
ATOM   1638 H HE   . ARG A 1 114 ? -43.880 43.204 -12.526 1.00 55.78  ? 114 ARG A HE   1 
ATOM   1639 H HH11 . ARG A 1 114 ? -45.711 40.687 -13.569 1.00 51.76  ? 114 ARG A HH11 1 
ATOM   1640 H HH12 . ARG A 1 114 ? -46.178 40.239 -12.227 1.00 51.76  ? 114 ARG A HH12 1 
ATOM   1641 H HH21 . ARG A 1 114 ? -44.603 42.532 -10.449 1.00 57.27  ? 114 ARG A HH21 1 
ATOM   1642 H HH22 . ARG A 1 114 ? -45.508 41.354 -10.335 1.00 57.27  ? 114 ARG A HH22 1 
ATOM   1643 N N    . ASP A 1 115 ? -41.421 46.120 -15.412 1.00 45.48  ? 115 ASP A N    1 
ATOM   1644 C CA   . ASP A 1 115 ? -41.487 47.491 -14.929 1.00 51.33  ? 115 ASP A CA   1 
ATOM   1645 C C    . ASP A 1 115 ? -42.400 47.585 -13.713 1.00 49.01  ? 115 ASP A C    1 
ATOM   1646 O O    . ASP A 1 115 ? -43.122 46.646 -13.370 1.00 50.37  ? 115 ASP A O    1 
ATOM   1647 C CB   . ASP A 1 115 ? -42.042 48.430 -15.995 1.00 52.66  ? 115 ASP A CB   1 
ATOM   1648 C CG   . ASP A 1 115 ? -41.149 48.544 -17.181 1.00 60.22  ? 115 ASP A CG   1 
ATOM   1649 O OD1  . ASP A 1 115 ? -39.916 48.372 -17.017 1.00 67.01  ? 115 ASP A OD1  1 
ATOM   1650 O OD2  . ASP A 1 115 ? -41.696 48.799 -18.277 1.00 71.89  ? 115 ASP A OD2  1 
ATOM   1651 H H    . ASP A 1 115 ? -41.869 45.970 -16.130 1.00 54.63  ? 115 ASP A H    1 
ATOM   1652 H HA   . ASP A 1 115 ? -40.585 47.762 -14.697 1.00 61.65  ? 115 ASP A HA   1 
ATOM   1653 H HB2  . ASP A 1 115 ? -42.900 48.094 -16.296 1.00 63.24  ? 115 ASP A HB2  1 
ATOM   1654 H HB3  . ASP A 1 115 ? -42.147 49.315 -15.612 1.00 63.24  ? 115 ASP A HB3  1 
ATOM   1655 N N    . ALA A 1 116 ? -42.389 48.753 -13.082 1.00 42.48  ? 116 ALA A N    1 
ATOM   1656 C CA   . ALA A 1 116 ? -43.372 49.052 -12.055 1.00 51.59  ? 116 ALA A CA   1 
ATOM   1657 C C    . ALA A 1 116 ? -44.772 48.767 -12.574 1.00 50.53  ? 116 ALA A C    1 
ATOM   1658 O O    . ALA A 1 116 ? -45.088 48.968 -13.752 1.00 44.70  ? 116 ALA A O    1 
ATOM   1659 C CB   . ALA A 1 116 ? -43.273 50.521 -11.618 1.00 48.37  ? 116 ALA A CB   1 
ATOM   1660 H H    . ALA A 1 116 ? -41.825 49.385 -13.231 1.00 51.03  ? 116 ALA A H    1 
ATOM   1661 H HA   . ALA A 1 116 ? -43.200 48.496 -11.279 1.00 61.95  ? 116 ALA A HA   1 
ATOM   1662 H HB1  . ALA A 1 116 ? -42.375 50.694 -11.294 1.00 58.09  ? 116 ALA A HB1  1 
ATOM   1663 H HB2  . ALA A 1 116 ? -43.916 50.685 -10.911 1.00 58.09  ? 116 ALA A HB2  1 
ATOM   1664 H HB3  . ALA A 1 116 ? -43.465 51.091 -12.379 1.00 58.09  ? 116 ALA A HB3  1 
ATOM   1665 N N    . ILE A 1 117 ? -45.588 48.206 -11.719 1.00 50.01  ? 117 ILE A N    1 
ATOM   1666 C CA   . ILE A 1 117 ? -47.005 48.122 -12.005 1.00 46.45  ? 117 ILE A CA   1 
ATOM   1667 C C    . ILE A 1 117 ? -47.647 49.431 -11.574 1.00 45.66  ? 117 ILE A C    1 
ATOM   1668 O O    . ILE A 1 117 ? -47.405 49.921 -10.459 1.00 43.20  ? 117 ILE A O    1 
ATOM   1669 C CB   . ILE A 1 117 ? -47.632 46.917 -11.316 1.00 48.71  ? 117 ILE A CB   1 
ATOM   1670 C CG1  . ILE A 1 117 ? -46.983 45.687 -11.938 1.00 43.75  ? 117 ILE A CG1  1 
ATOM   1671 C CG2  . ILE A 1 117 ? -49.122 46.920 -11.561 1.00 42.24  ? 117 ILE A CG2  1 
ATOM   1672 C CD1  . ILE A 1 117 ? -46.787 44.653 -10.959 1.00 50.99  ? 117 ILE A CD1  1 
ATOM   1673 H H    . ILE A 1 117 ? -45.350 47.865 -10.966 1.00 60.07  ? 117 ILE A H    1 
ATOM   1674 H HA   . ILE A 1 117 ? -47.150 48.014 -12.959 1.00 55.79  ? 117 ILE A HA   1 
ATOM   1675 H HB   . ILE A 1 117 ? -47.489 46.933 -10.357 1.00 58.50  ? 117 ILE A HB   1 
ATOM   1676 H HG12 . ILE A 1 117 ? -47.557 45.341 -12.639 1.00 52.55  ? 117 ILE A HG12 1 
ATOM   1677 H HG13 . ILE A 1 117 ? -46.119 45.930 -12.305 1.00 52.55  ? 117 ILE A HG13 1 
ATOM   1678 H HG21 . ILE A 1 117 ? -49.478 46.042 -11.351 1.00 50.74  ? 117 ILE A HG21 1 
ATOM   1679 H HG22 . ILE A 1 117 ? -49.534 47.589 -10.991 1.00 50.74  ? 117 ILE A HG22 1 
ATOM   1680 H HG23 . ILE A 1 117 ? -49.289 47.131 -12.493 1.00 50.74  ? 117 ILE A HG23 1 
ATOM   1681 H HD11 . ILE A 1 117 ? -47.505 44.695 -10.307 1.00 61.23  ? 117 ILE A HD11 1 
ATOM   1682 H HD12 . ILE A 1 117 ? -46.795 43.791 -11.404 1.00 61.23  ? 117 ILE A HD12 1 
ATOM   1683 H HD13 . ILE A 1 117 ? -45.933 44.791 -10.520 1.00 61.23  ? 117 ILE A HD13 1 
ATOM   1684 N N    . LYS A 1 118 ? -48.408 50.044 -12.484 1.00 46.31  ? 118 LYS A N    1 
ATOM   1685 C CA   . LYS A 1 118 ? -48.942 51.373 -12.174 1.00 59.70  ? 118 LYS A CA   1 
ATOM   1686 C C    . LYS A 1 118 ? -49.959 51.273 -11.046 1.00 52.71  ? 118 LYS A C    1 
ATOM   1687 O O    . LYS A 1 118 ? -50.599 50.234 -10.854 1.00 46.69  ? 118 LYS A O    1 
ATOM   1688 C CB   . LYS A 1 118 ? -49.433 52.098 -13.418 1.00 64.78  ? 118 LYS A CB   1 
ATOM   1689 C CG   . LYS A 1 118 ? -48.124 52.682 -13.907 1.00 82.96  ? 118 LYS A CG   1 
ATOM   1690 C CD   . LYS A 1 118 ? -47.273 51.578 -14.510 1.00 93.20  ? 118 LYS A CD   1 
ATOM   1691 C CE   . LYS A 1 118 ? -45.863 52.178 -14.866 1.00 74.42  ? 118 LYS A CE   1 
ATOM   1692 N NZ   . LYS A 1 118 ? -44.940 51.057 -15.229 1.00 65.11  ? 118 LYS A NZ   1 
ATOM   1693 N N    . SER A 1 119 ? -50.030 52.352 -10.257 1.00 50.91  ? 119 SER A N    1 
ATOM   1694 C CA   . SER A 1 119 ? -50.867 52.420 -9.060  1.00 48.34  ? 119 SER A CA   1 
ATOM   1695 C C    . SER A 1 119 ? -52.277 51.927 -9.322  1.00 53.35  ? 119 SER A C    1 
ATOM   1696 O O    . SER A 1 119 ? -52.886 51.239 -8.486  1.00 49.73  ? 119 SER A O    1 
ATOM   1697 C CB   . SER A 1 119 ? -50.960 53.863 -8.568  1.00 49.80  ? 119 SER A CB   1 
ATOM   1698 O OG   . SER A 1 119 ? -49.809 54.236 -7.866  1.00 58.48  ? 119 SER A OG   1 
ATOM   1699 N N    . ASN A 1 120 ? -52.835 52.358 -10.441 1.00 46.99  ? 120 ASN A N    1 
ATOM   1700 C CA   . ASN A 1 120 ? -54.238 52.111 -10.710 1.00 46.91  ? 120 ASN A CA   1 
ATOM   1701 C C    . ASN A 1 120 ? -54.459 50.739 -11.340 1.00 52.52  ? 120 ASN A C    1 
ATOM   1702 O O    . ASN A 1 120 ? -55.590 50.434 -11.741 1.00 53.86  ? 120 ASN A O    1 
ATOM   1703 C CB   . ASN A 1 120 ? -54.800 53.236 -11.603 1.00 54.05  ? 120 ASN A CB   1 
ATOM   1704 C CG   . ASN A 1 120 ? -54.660 54.650 -10.973 1.00 54.93  ? 120 ASN A CG   1 
ATOM   1705 O OD1  . ASN A 1 120 ? -54.721 54.829 -9.748  1.00 50.02  ? 120 ASN A OD1  1 
ATOM   1706 N ND2  . ASN A 1 120 ? -54.453 55.652 -11.826 1.00 67.24  ? 120 ASN A ND2  1 
ATOM   1707 N N    . ASN A 1 121 ? -53.421 49.888 -11.380 1.00 49.94  ? 121 ASN A N    1 
ATOM   1708 C CA   . ASN A 1 121 ? -53.501 48.558 -11.968 1.00 45.26  ? 121 ASN A CA   1 
ATOM   1709 C C    . ASN A 1 121 ? -53.346 47.492 -10.892 1.00 46.59  ? 121 ASN A C    1 
ATOM   1710 O O    . ASN A 1 121 ? -52.326 47.434 -10.205 1.00 42.56  ? 121 ASN A O    1 
ATOM   1711 C CB   . ASN A 1 121 ? -52.427 48.388 -13.040 1.00 52.19  ? 121 ASN A CB   1 
ATOM   1712 C CG   . ASN A 1 121 ? -52.805 49.039 -14.343 1.00 57.51  ? 121 ASN A CG   1 
ATOM   1713 O OD1  . ASN A 1 121 ? -53.984 49.306 -14.595 1.00 60.91  ? 121 ASN A OD1  1 
ATOM   1714 N ND2  . ASN A 1 121 ? -51.817 49.299 -15.181 1.00 57.16  ? 121 ASN A ND2  1 
ATOM   1715 N N    . HIS A 1 122 ? -54.312 46.604 -10.780 1.00 44.35  ? 122 HIS A N    1 
ATOM   1716 C CA   . HIS A 1 122 ? -54.198 45.628 -9.712  1.00 46.79  ? 122 HIS A CA   1 
ATOM   1717 C C    . HIS A 1 122 ? -53.424 44.411 -10.209 1.00 47.93  ? 122 HIS A C    1 
ATOM   1718 O O    . HIS A 1 122 ? -53.499 44.049 -11.387 1.00 45.46  ? 122 HIS A O    1 
ATOM   1719 C CB   . HIS A 1 122 ? -55.580 45.229 -9.223  1.00 47.74  ? 122 HIS A CB   1 
ATOM   1720 C CG   . HIS A 1 122 ? -56.421 44.617 -10.294 1.00 45.70  ? 122 HIS A CG   1 
ATOM   1721 N ND1  . HIS A 1 122 ? -56.487 43.253 -10.489 1.00 48.00  ? 122 HIS A ND1  1 
ATOM   1722 C CD2  . HIS A 1 122 ? -57.251 45.174 -11.210 1.00 46.83  ? 122 HIS A CD2  1 
ATOM   1723 C CE1  . HIS A 1 122 ? -57.320 42.990 -11.482 1.00 49.24  ? 122 HIS A CE1  1 
ATOM   1724 N NE2  . HIS A 1 122 ? -57.790 44.143 -11.943 1.00 52.53  ? 122 HIS A NE2  1 
ATOM   1725 N N    . LEU A 1 123 ? -52.681 43.782 -9.295  1.00 45.69  ? 123 LEU A N    1 
ATOM   1726 C CA   . LEU A 1 123 ? -51.663 42.809 -9.685  1.00 51.75  ? 123 LEU A CA   1 
ATOM   1727 C C    . LEU A 1 123 ? -52.299 41.571 -10.314 1.00 56.98  ? 123 LEU A C    1 
ATOM   1728 O O    . LEU A 1 123 ? -53.300 41.043 -9.818  1.00 49.09  ? 123 LEU A O    1 
ATOM   1729 C CB   . LEU A 1 123 ? -50.807 42.397 -8.477  1.00 50.31  ? 123 LEU A CB   1 
ATOM   1730 C CG   . LEU A 1 123 ? -49.699 41.394 -8.828  1.00 54.42  ? 123 LEU A CG   1 
ATOM   1731 C CD1  . LEU A 1 123 ? -48.950 41.856 -10.088 1.00 54.94  ? 123 LEU A CD1  1 
ATOM   1732 C CD2  . LEU A 1 123 ? -48.714 41.135 -7.653  1.00 65.87  ? 123 LEU A CD2  1 
ATOM   1733 N N    . THR A 1 124 ? -51.689 41.089 -11.396 1.00 63.38  ? 124 THR A N    1 
ATOM   1734 C CA   . THR A 1 124 ? -52.242 40.004 -12.217 1.00 69.06  ? 124 THR A CA   1 
ATOM   1735 C C    . THR A 1 124 ? -51.544 38.661 -12.033 1.00 67.60  ? 124 THR A C    1 
ATOM   1736 O O    . THR A 1 124 ? -52.211 37.611 -12.094 1.00 66.02  ? 124 THR A O    1 
ATOM   1737 C CB   . THR A 1 124 ? -52.141 40.382 -13.701 1.00 71.38  ? 124 THR A CB   1 
ATOM   1738 O OG1  . THR A 1 124 ? -52.555 39.264 -14.495 1.00 80.66  ? 124 THR A OG1  1 
ATOM   1739 C CG2  . THR A 1 124 ? -50.678 40.774 -14.075 1.00 74.12  ? 124 THR A CG2  1 
ATOM   1740 H H    . THR A 1 124 ? -50.933 41.379 -11.685 1.00 76.11  ? 124 THR A H    1 
ATOM   1741 H HA   . THR A 1 124 ? -53.172 39.891 -11.965 1.00 82.92  ? 124 THR A HA   1 
ATOM   1742 H HB   . THR A 1 124 ? -52.711 41.145 -13.886 1.00 85.71  ? 124 THR A HB   1 
ATOM   1743 H HG1  . THR A 1 124 ? -52.254 39.338 -15.275 1.00 96.84  ? 124 THR A HG1  1 
ATOM   1744 H HG21 . THR A 1 124 ? -50.659 41.181 -14.955 1.00 88.99  ? 124 THR A HG21 1 
ATOM   1745 H HG22 . THR A 1 124 ? -50.329 41.406 -13.428 1.00 88.99  ? 124 THR A HG22 1 
ATOM   1746 H HG23 . THR A 1 124 ? -50.115 39.984 -14.081 1.00 88.99  ? 124 THR A HG23 1 
ATOM   1747 N N    . GLU A 1 125 ? -50.205 38.640 -11.960 1.00 61.42  ? 125 GLU A N    1 
ATOM   1748 C CA   . GLU A 1 125 ? -49.529 37.416 -11.484 1.00 59.19  ? 125 GLU A CA   1 
ATOM   1749 C C    . GLU A 1 125 ? -48.237 37.691 -10.713 1.00 53.19  ? 125 GLU A C    1 
ATOM   1750 O O    . GLU A 1 125 ? -47.608 38.763 -10.799 1.00 49.76  ? 125 GLU A O    1 
ATOM   1751 C CB   . GLU A 1 125 ? -49.086 36.375 -12.573 1.00 67.65  ? 125 GLU A CB   1 
ATOM   1752 C CG   . GLU A 1 125 ? -50.001 35.196 -12.986 1.00 70.22  ? 125 GLU A CG   1 
ATOM   1753 C CD   . GLU A 1 125 ? -50.131 34.127 -11.795 1.00 73.85  ? 125 GLU A CD   1 
ATOM   1754 O OE1  . GLU A 1 125 ? -49.313 34.067 -10.809 1.00 52.40  ? 125 GLU A OE1  1 
ATOM   1755 O OE2  . GLU A 1 125 ? -50.930 33.191 -11.925 1.00 77.53  ? 125 GLU A OE2  1 
ATOM   1756 H H    . GLU A 1 125 ? -49.685 39.291 -12.172 1.00 73.75  ? 125 GLU A H    1 
ATOM   1757 H HA   . GLU A 1 125 ? -50.226 37.054 -10.915 1.00 71.07  ? 125 GLU A HA   1 
ATOM   1758 H HB2  . GLU A 1 125 ? -48.918 36.874 -13.388 1.00 81.23  ? 125 GLU A HB2  1 
ATOM   1759 H HB3  . GLU A 1 125 ? -48.264 35.969 -12.257 1.00 81.23  ? 125 GLU A HB3  1 
ATOM   1760 H HG2  . GLU A 1 125 ? -50.886 35.532 -13.196 1.00 84.32  ? 125 GLU A HG2  1 
ATOM   1761 H HG3  . GLU A 1 125 ? -49.623 34.750 -13.760 1.00 84.32  ? 125 GLU A HG3  1 
ATOM   1762 N N    . ASN A 1 126 ? -47.826 36.627 -10.016 1.00 52.74  ? 126 ASN A N    1 
ATOM   1763 C CA   . ASN A 1 126 ? -46.775 36.644 -9.025  1.00 45.67  ? 126 ASN A CA   1 
ATOM   1764 C C    . ASN A 1 126 ? -45.444 36.466 -9.739  1.00 47.25  ? 126 ASN A C    1 
ATOM   1765 O O    . ASN A 1 126 ? -45.145 35.388 -10.267 1.00 43.49  ? 126 ASN A O    1 
ATOM   1766 C CB   . ASN A 1 126 ? -46.970 35.549 -7.974  1.00 44.37  ? 126 ASN A CB   1 
ATOM   1767 C CG   . ASN A 1 126 ? -46.025 35.745 -6.819  1.00 44.79  ? 126 ASN A CG   1 
ATOM   1768 O OD1  . ASN A 1 126 ? -45.259 36.691 -6.845  1.00 30.64  ? 126 ASN A OD1  1 
ATOM   1769 N ND2  . ASN A 1 126 ? -46.053 34.852 -5.816  1.00 41.70  ? 126 ASN A ND2  1 
ATOM   1770 H H    . ASN A 1 126 ? -48.167 35.844 -10.114 1.00 63.33  ? 126 ASN A H    1 
ATOM   1771 H HA   . ASN A 1 126 ? -46.790 37.501 -8.570  1.00 54.86  ? 126 ASN A HA   1 
ATOM   1772 H HB2  . ASN A 1 126 ? -47.879 35.580 -7.638  1.00 53.30  ? 126 ASN A HB2  1 
ATOM   1773 H HB3  . ASN A 1 126 ? -46.793 34.682 -8.373  1.00 53.30  ? 126 ASN A HB3  1 
ATOM   1774 H HD21 . ASN A 1 126 ? -46.601 34.190 -5.845  1.00 50.09  ? 126 ASN A HD21 1 
ATOM   1775 H HD22 . ASN A 1 126 ? -45.523 34.942 -5.145  1.00 50.09  ? 126 ASN A HD22 1 
ATOM   1776 N N    . ASN A 1 127 ? -44.640 37.518 -9.746  1.00 47.81  ? 127 ASN A N    1 
ATOM   1777 C CA   . ASN A 1 127 ? -43.351 37.489 -10.412 1.00 45.94  ? 127 ASN A CA   1 
ATOM   1778 C C    . ASN A 1 127 ? -42.227 37.010 -9.524  1.00 45.97  ? 127 ASN A C    1 
ATOM   1779 O O    . ASN A 1 127 ? -41.096 36.869 -10.009 1.00 43.02  ? 127 ASN A O    1 
ATOM   1780 C CB   . ASN A 1 127 ? -42.977 38.883 -10.900 1.00 45.05  ? 127 ASN A CB   1 
ATOM   1781 C CG   . ASN A 1 127 ? -41.910 38.853 -11.960 1.00 42.10  ? 127 ASN A CG   1 
ATOM   1782 O OD1  . ASN A 1 127 ? -41.896 37.958 -12.831 1.00 41.75  ? 127 ASN A OD1  1 
ATOM   1783 N ND2  . ASN A 1 127 ? -40.995 39.819 -11.896 1.00 40.30  ? 127 ASN A ND2  1 
ATOM   1784 H H    . ASN A 1 127 ? -44.822 38.269 -9.368  1.00 57.42  ? 127 ASN A H    1 
ATOM   1785 H HA   . ASN A 1 127 ? -43.430 36.892 -11.172 1.00 55.18  ? 127 ASN A HA   1 
ATOM   1786 H HB2  . ASN A 1 127 ? -43.763 39.310 -11.276 1.00 54.12  ? 127 ASN A HB2  1 
ATOM   1787 H HB3  . ASN A 1 127 ? -42.643 39.402 -10.152 1.00 54.12  ? 127 ASN A HB3  1 
ATOM   1788 H HD21 . ASN A 1 127 ? -41.038 40.411 -11.274 1.00 48.42  ? 127 ASN A HD21 1 
ATOM   1789 H HD22 . ASN A 1 127 ? -40.362 39.851 -12.477 1.00 48.42  ? 127 ASN A HD22 1 
ATOM   1790 N N    . LEU A 1 128 ? -42.501 36.794 -8.247  1.00 41.61  ? 128 LEU A N    1 
ATOM   1791 C CA   . LEU A 1 128 ? -41.479 36.454 -7.284  1.00 40.45  ? 128 LEU A CA   1 
ATOM   1792 C C    . LEU A 1 128 ? -41.550 34.979 -6.924  1.00 37.70  ? 128 LEU A C    1 
ATOM   1793 O O    . LEU A 1 128 ? -42.600 34.347 -7.016  1.00 38.90  ? 128 LEU A O    1 
ATOM   1794 C CB   . LEU A 1 128 ? -41.649 37.324 -6.045  1.00 35.67  ? 128 LEU A CB   1 
ATOM   1795 C CG   . LEU A 1 128 ? -41.797 38.829 -6.362  1.00 44.71  ? 128 LEU A CG   1 
ATOM   1796 C CD1  . LEU A 1 128 ? -41.914 39.657 -5.084  1.00 33.00  ? 128 LEU A CD1  1 
ATOM   1797 C CD2  . LEU A 1 128 ? -40.598 39.359 -7.182  1.00 44.16  ? 128 LEU A CD2  1 
ATOM   1798 H H    . LEU A 1 128 ? -43.291 36.840 -7.911  1.00 49.98  ? 128 LEU A H    1 
ATOM   1799 H HA   . LEU A 1 128 ? -40.595 36.605 -7.655  1.00 48.59  ? 128 LEU A HA   1 
ATOM   1800 H HB2  . LEU A 1 128 ? -42.446 37.040 -5.571  1.00 42.86  ? 128 LEU A HB2  1 
ATOM   1801 H HB3  . LEU A 1 128 ? -40.869 37.215 -5.478  1.00 42.86  ? 128 LEU A HB3  1 
ATOM   1802 H HG   . LEU A 1 128 ? -42.607 38.930 -6.886  1.00 53.70  ? 128 LEU A HG   1 
ATOM   1803 H HD11 . LEU A 1 128 ? -42.802 39.539 -4.711  1.00 39.65  ? 128 LEU A HD11 1 
ATOM   1804 H HD12 . LEU A 1 128 ? -41.766 40.591 -5.298  1.00 39.65  ? 128 LEU A HD12 1 
ATOM   1805 H HD13 . LEU A 1 128 ? -41.246 39.353 -4.449  1.00 39.65  ? 128 LEU A HD13 1 
ATOM   1806 H HD21 . LEU A 1 128 ? -40.730 40.303 -7.361  1.00 53.04  ? 128 LEU A HD21 1 
ATOM   1807 H HD22 . LEU A 1 128 ? -39.784 39.229 -6.672  1.00 53.04  ? 128 LEU A HD22 1 
ATOM   1808 H HD23 . LEU A 1 128 ? -40.546 38.868 -8.018  1.00 53.04  ? 128 LEU A HD23 1 
ATOM   1809 N N    . TYR A 1 129 ? -40.415 34.442 -6.506  1.00 37.69  ? 129 TYR A N    1 
ATOM   1810 C CA   . TYR A 1 129 ? -40.357 33.085 -5.976  1.00 39.89  ? 129 TYR A CA   1 
ATOM   1811 C C    . TYR A 1 129 ? -40.635 33.099 -4.472  1.00 37.58  ? 129 TYR A C    1 
ATOM   1812 O O    . TYR A 1 129 ? -39.846 32.624 -3.655  1.00 32.60  ? 129 TYR A O    1 
ATOM   1813 C CB   . TYR A 1 129 ? -38.997 32.479 -6.278  1.00 35.67  ? 129 TYR A CB   1 
ATOM   1814 C CG   . TYR A 1 129 ? -38.743 32.310 -7.764  1.00 39.42  ? 129 TYR A CG   1 
ATOM   1815 C CD1  . TYR A 1 129 ? -39.487 31.435 -8.538  1.00 34.93  ? 129 TYR A CD1  1 
ATOM   1816 C CD2  . TYR A 1 129 ? -37.740 33.033 -8.396  1.00 40.15  ? 129 TYR A CD2  1 
ATOM   1817 C CE1  . TYR A 1 129 ? -39.223 31.266 -9.887  1.00 37.15  ? 129 TYR A CE1  1 
ATOM   1818 C CE2  . TYR A 1 129 ? -37.500 32.883 -9.745  1.00 38.56  ? 129 TYR A CE2  1 
ATOM   1819 C CZ   . TYR A 1 129 ? -38.233 32.012 -10.469 1.00 37.23  ? 129 TYR A CZ   1 
ATOM   1820 O OH   . TYR A 1 129 ? -37.957 31.868 -11.803 1.00 47.65  ? 129 TYR A OH   1 
ATOM   1821 H H    . TYR A 1 129 ? -39.656 34.845 -6.517  1.00 45.28  ? 129 TYR A H    1 
ATOM   1822 H HA   . TYR A 1 129 ? -41.037 32.542 -6.405  1.00 47.92  ? 129 TYR A HA   1 
ATOM   1823 H HB2  . TYR A 1 129 ? -38.307 33.059 -5.920  1.00 42.85  ? 129 TYR A HB2  1 
ATOM   1824 H HB3  . TYR A 1 129 ? -38.943 31.604 -5.864  1.00 42.85  ? 129 TYR A HB3  1 
ATOM   1825 H HD1  . TYR A 1 129 ? -40.177 30.951 -8.144  1.00 41.97  ? 129 TYR A HD1  1 
ATOM   1826 H HD2  . TYR A 1 129 ? -37.223 33.627 -7.902  1.00 48.23  ? 129 TYR A HD2  1 
ATOM   1827 H HE1  . TYR A 1 129 ? -39.711 30.655 -10.390 1.00 44.63  ? 129 TYR A HE1  1 
ATOM   1828 H HE2  . TYR A 1 129 ? -36.833 33.383 -10.156 1.00 46.33  ? 129 TYR A HE2  1 
ATOM   1829 H HH   . TYR A 1 129 ? -38.355 31.194 -12.107 1.00 57.24  ? 129 TYR A HH   1 
ATOM   1830 N N    . ILE A 1 130 ? -41.806 33.644 -4.127  1.00 28.87  ? 130 ILE A N    1 
ATOM   1831 C CA   . ILE A 1 130 ? -42.244 33.811 -2.746  1.00 32.01  ? 130 ILE A CA   1 
ATOM   1832 C C    . ILE A 1 130 ? -43.739 33.554 -2.711  1.00 33.81  ? 130 ILE A C    1 
ATOM   1833 O O    . ILE A 1 130 ? -44.475 34.092 -3.549  1.00 32.43  ? 130 ILE A O    1 
ATOM   1834 C CB   . ILE A 1 130 ? -41.985 35.236 -2.191  1.00 30.62  ? 130 ILE A CB   1 
ATOM   1835 C CG1  . ILE A 1 130 ? -40.570 35.713 -2.414  1.00 38.33  ? 130 ILE A CG1  1 
ATOM   1836 C CG2  . ILE A 1 130 ? -42.279 35.281 -0.651  1.00 38.27  ? 130 ILE A CG2  1 
ATOM   1837 C CD1  . ILE A 1 130 ? -40.410 37.232 -2.215  1.00 40.77  ? 130 ILE A CD1  1 
ATOM   1838 H H    . ILE A 1 130 ? -42.380 33.933 -4.698  1.00 34.70  ? 130 ILE A H    1 
ATOM   1839 H HA   . ILE A 1 130 ? -41.766 33.171 -2.196  1.00 38.47  ? 130 ILE A HA   1 
ATOM   1840 H HB   . ILE A 1 130 ? -42.583 35.823 -2.680  1.00 36.80  ? 130 ILE A HB   1 
ATOM   1841 H HG12 . ILE A 1 130 ? -39.983 35.264 -1.786  1.00 46.05  ? 130 ILE A HG12 1 
ATOM   1842 H HG13 . ILE A 1 130 ? -40.306 35.501 -3.323  1.00 46.05  ? 130 ILE A HG13 1 
ATOM   1843 H HG21 . ILE A 1 130 ? -41.716 34.631 -0.202  1.00 45.97  ? 130 ILE A HG21 1 
ATOM   1844 H HG22 . ILE A 1 130 ? -42.085 36.172 -0.318  1.00 45.97  ? 130 ILE A HG22 1 
ATOM   1845 H HG23 . ILE A 1 130 ? -43.214 35.069 -0.501  1.00 45.97  ? 130 ILE A HG23 1 
ATOM   1846 H HD11 . ILE A 1 130 ? -41.002 37.696 -2.828  1.00 48.98  ? 130 ILE A HD11 1 
ATOM   1847 H HD12 . ILE A 1 130 ? -40.640 37.456 -1.299  1.00 48.98  ? 130 ILE A HD12 1 
ATOM   1848 H HD13 . ILE A 1 130 ? -39.489 37.479 -2.394  1.00 48.98  ? 130 ILE A HD13 1 
ATOM   1849 N N    . SER A 1 131 ? -44.195 32.741 -1.763  1.00 32.74  ? 131 SER A N    1 
ATOM   1850 C CA   . SER A 1 131 ? -45.610 32.475 -1.573  1.00 35.29  ? 131 SER A CA   1 
ATOM   1851 C C    . SER A 1 131 ? -46.307 32.103 -2.888  1.00 38.09  ? 131 SER A C    1 
ATOM   1852 O O    . SER A 1 131 ? -47.428 32.520 -3.187  1.00 38.48  ? 131 SER A O    1 
ATOM   1853 C CB   . SER A 1 131 ? -46.273 33.675 -0.903  1.00 31.93  ? 131 SER A CB   1 
ATOM   1854 O OG   . SER A 1 131 ? -45.703 33.921 0.376   1.00 35.24  ? 131 SER A OG   1 
ATOM   1855 H H    . SER A 1 131 ? -43.690 32.324 -1.205  1.00 39.34  ? 131 SER A H    1 
ATOM   1856 H HA   . SER A 1 131 ? -45.705 31.702 -0.994  1.00 42.40  ? 131 SER A HA   1 
ATOM   1857 H HB2  . SER A 1 131 ? -46.146 34.458 -1.461  1.00 38.37  ? 131 SER A HB2  1 
ATOM   1858 H HB3  . SER A 1 131 ? -47.220 33.494 -0.797  1.00 38.37  ? 131 SER A HB3  1 
ATOM   1859 H HG   . SER A 1 131 ? -45.843 34.717 0.606   1.00 42.34  ? 131 SER A HG   1 
ATOM   1860 N N    . ASP A 1 132 ? -45.653 31.259 -3.662  1.00 36.88  ? 132 ASP A N    1 
ATOM   1861 C CA   . ASP A 1 132 ? -46.133 30.857 -4.990  1.00 34.41  ? 132 ASP A CA   1 
ATOM   1862 C C    . ASP A 1 132 ? -46.402 29.352 -4.934  1.00 40.38  ? 132 ASP A C    1 
ATOM   1863 O O    . ASP A 1 132 ? -45.469 28.557 -5.064  1.00 36.04  ? 132 ASP A O    1 
ATOM   1864 C CB   . ASP A 1 132 ? -45.074 31.197 -6.037  1.00 36.79  ? 132 ASP A CB   1 
ATOM   1865 C CG   . ASP A 1 132 ? -45.466 30.800 -7.428  1.00 41.83  ? 132 ASP A CG   1 
ATOM   1866 O OD1  . ASP A 1 132 ? -46.611 30.368 -7.637  1.00 41.68  ? 132 ASP A OD1  1 
ATOM   1867 O OD2  . ASP A 1 132 ? -44.634 30.916 -8.326  1.00 42.40  ? 132 ASP A OD2  1 
ATOM   1868 H H    . ASP A 1 132 ? -44.907 30.891 -3.443  1.00 44.30  ? 132 ASP A H    1 
ATOM   1869 H HA   . ASP A 1 132 ? -46.960 31.311 -5.213  1.00 41.34  ? 132 ASP A HA   1 
ATOM   1870 H HB2  . ASP A 1 132 ? -44.923 32.155 -6.032  1.00 44.20  ? 132 ASP A HB2  1 
ATOM   1871 H HB3  . ASP A 1 132 ? -44.252 30.731 -5.815  1.00 44.20  ? 132 ASP A HB3  1 
ATOM   1872 N N    . TYR A 1 133 ? -47.657 28.970 -4.700  1.00 31.53  ? 133 TYR A N    1 
ATOM   1873 C CA   . TYR A 1 133 ? -48.032 27.590 -4.555  1.00 37.18  ? 133 TYR A CA   1 
ATOM   1874 C C    . TYR A 1 133 ? -47.811 26.827 -5.845  1.00 38.85  ? 133 TYR A C    1 
ATOM   1875 O O    . TYR A 1 133 ? -47.730 25.597 -5.814  1.00 35.77  ? 133 TYR A O    1 
ATOM   1876 C CB   . TYR A 1 133 ? -49.506 27.500 -4.076  1.00 36.25  ? 133 TYR A CB   1 
ATOM   1877 C CG   . TYR A 1 133 ? -50.522 27.991 -5.054  1.00 39.39  ? 133 TYR A CG   1 
ATOM   1878 C CD1  . TYR A 1 133 ? -50.835 29.327 -5.150  1.00 40.35  ? 133 TYR A CD1  1 
ATOM   1879 C CD2  . TYR A 1 133 ? -51.162 27.098 -5.903  1.00 40.98  ? 133 TYR A CD2  1 
ATOM   1880 C CE1  . TYR A 1 133 ? -51.745 29.771 -6.091  1.00 41.24  ? 133 TYR A CE1  1 
ATOM   1881 C CE2  . TYR A 1 133 ? -52.058 27.512 -6.819  1.00 44.77  ? 133 TYR A CE2  1 
ATOM   1882 C CZ   . TYR A 1 133 ? -52.350 28.849 -6.926  1.00 47.50  ? 133 TYR A CZ   1 
ATOM   1883 O OH   . TYR A 1 133 ? -53.257 29.252 -7.870  1.00 56.29  ? 133 TYR A OH   1 
ATOM   1884 H H    . TYR A 1 133 ? -48.320 29.513 -4.622  1.00 37.89  ? 133 TYR A H    1 
ATOM   1885 H HA   . TYR A 1 133 ? -47.492 27.163 -3.872  1.00 44.66  ? 133 TYR A HA   1 
ATOM   1886 H HB2  . TYR A 1 133 ? -49.711 26.571 -3.887  1.00 43.56  ? 133 TYR A HB2  1 
ATOM   1887 H HB3  . TYR A 1 133 ? -49.600 28.031 -3.269  1.00 43.56  ? 133 TYR A HB3  1 
ATOM   1888 H HD1  . TYR A 1 133 ? -50.430 29.938 -4.576  1.00 48.47  ? 133 TYR A HD1  1 
ATOM   1889 H HD2  . TYR A 1 133 ? -50.967 26.191 -5.837  1.00 49.22  ? 133 TYR A HD2  1 
ATOM   1890 H HE1  . TYR A 1 133 ? -51.948 30.676 -6.162  1.00 49.54  ? 133 TYR A HE1  1 
ATOM   1891 H HE2  . TYR A 1 133 ? -52.476 26.896 -7.377  1.00 53.77  ? 133 TYR A HE2  1 
ATOM   1892 H HH   . TYR A 1 133 ? -53.307 30.091 -7.880  1.00 67.60  ? 133 TYR A HH   1 
ATOM   1893 N N    . LYS A 1 134 ? -47.685 27.522 -6.971  1.00 37.47  ? 134 LYS A N    1 
ATOM   1894 C CA   . LYS A 1 134 ? -47.497 26.851 -8.246  1.00 39.36  ? 134 LYS A CA   1 
ATOM   1895 C C    . LYS A 1 134 ? -46.075 26.317 -8.453  1.00 42.16  ? 134 LYS A C    1 
ATOM   1896 O O    . LYS A 1 134 ? -45.849 25.509 -9.356  1.00 35.79  ? 134 LYS A O    1 
ATOM   1897 C CB   . LYS A 1 134 ? -47.855 27.822 -9.371  1.00 47.81  ? 134 LYS A CB   1 
ATOM   1898 C CG   . LYS A 1 134 ? -49.360 28.137 -9.500  1.00 48.16  ? 134 LYS A CG   1 
ATOM   1899 C CD   . LYS A 1 134 ? -49.617 29.192 -10.589 1.00 50.90  ? 134 LYS A CD   1 
ATOM   1900 C CE   . LYS A 1 134 ? -51.105 29.538 -10.774 1.00 54.49  ? 134 LYS A CE   1 
ATOM   1901 N NZ   . LYS A 1 134 ? -51.267 30.624 -11.800 1.00 67.81  ? 134 LYS A NZ   1 
ATOM   1902 H H    . LYS A 1 134 ? -47.705 28.380 -7.020  1.00 45.02  ? 134 LYS A H    1 
ATOM   1903 H HA   . LYS A 1 134 ? -48.092 26.085 -8.292  1.00 47.28  ? 134 LYS A HA   1 
ATOM   1904 H HB2  . LYS A 1 134 ? -47.394 28.661 -9.212  1.00 57.43  ? 134 LYS A HB2  1 
ATOM   1905 H HB3  . LYS A 1 134 ? -47.564 27.438 -10.213 1.00 57.43  ? 134 LYS A HB3  1 
ATOM   1906 H HG2  . LYS A 1 134 ? -49.839 27.328 -9.738  1.00 57.84  ? 134 LYS A HG2  1 
ATOM   1907 H HG3  . LYS A 1 134 ? -49.691 28.481 -8.656  1.00 57.84  ? 134 LYS A HG3  1 
ATOM   1908 H HD2  . LYS A 1 134 ? -49.151 30.008 -10.350 1.00 61.13  ? 134 LYS A HD2  1 
ATOM   1909 H HD3  . LYS A 1 134 ? -49.285 28.855 -11.435 1.00 61.13  ? 134 LYS A HD3  1 
ATOM   1910 H HE2  . LYS A 1 134 ? -51.587 28.753 -11.076 1.00 65.44  ? 134 LYS A HE2  1 
ATOM   1911 H HE3  . LYS A 1 134 ? -51.474 29.850 -9.932  1.00 65.44  ? 134 LYS A HE3  1 
ATOM   1912 H HZ1  . LYS A 1 134 ? -52.126 30.844 -11.878 1.00 81.42  ? 134 LYS A HZ1  1 
ATOM   1913 H HZ2  . LYS A 1 134 ? -50.805 31.345 -11.555 1.00 81.42  ? 134 LYS A HZ2  1 
ATOM   1914 H HZ3  . LYS A 1 134 ? -50.967 30.344 -12.589 1.00 81.42  ? 134 LYS A HZ3  1 
ATOM   1915 N N    . MET A 1 135 ? -45.119 26.717 -7.622  1.00 35.69  ? 135 MET A N    1 
ATOM   1916 C CA   . MET A 1 135 ? -43.795 26.135 -7.661  1.00 36.13  ? 135 MET A CA   1 
ATOM   1917 C C    . MET A 1 135 ? -43.771 24.688 -7.246  1.00 40.69  ? 135 MET A C    1 
ATOM   1918 O O    . MET A 1 135 ? -42.732 24.047 -7.404  1.00 41.11  ? 135 MET A O    1 
ATOM   1919 C CB   . MET A 1 135 ? -42.887 26.884 -6.726  1.00 34.83  ? 135 MET A CB   1 
ATOM   1920 C CG   . MET A 1 135 ? -42.577 28.285 -7.185  1.00 41.32  ? 135 MET A CG   1 
ATOM   1921 S SD   . MET A 1 135 ? -41.493 29.199 -6.121  1.00 34.55  ? 135 MET A SD   1 
ATOM   1922 C CE   . MET A 1 135 ? -39.853 28.593 -6.541  1.00 39.25  ? 135 MET A CE   1 
ATOM   1923 H H    . MET A 1 135 ? -45.217 27.327 -7.024  1.00 42.88  ? 135 MET A H    1 
ATOM   1924 H HA   . MET A 1 135 ? -43.470 26.217 -8.571  1.00 43.40  ? 135 MET A HA   1 
ATOM   1925 H HB2  . MET A 1 135 ? -43.314 26.944 -5.856  1.00 41.84  ? 135 MET A HB2  1 
ATOM   1926 H HB3  . MET A 1 135 ? -42.049 26.403 -6.651  1.00 41.84  ? 135 MET A HB3  1 
ATOM   1927 H HG2  . MET A 1 135 ? -42.154 28.236 -8.057  1.00 49.64  ? 135 MET A HG2  1 
ATOM   1928 H HG3  . MET A 1 135 ? -43.409 28.780 -7.247  1.00 49.64  ? 135 MET A HG3  1 
ATOM   1929 H HE1  . MET A 1 135 ? -39.826 27.634 -6.401  1.00 47.15  ? 135 MET A HE1  1 
ATOM   1930 H HE2  . MET A 1 135 ? -39.200 29.029 -5.971  1.00 47.15  ? 135 MET A HE2  1 
ATOM   1931 H HE3  . MET A 1 135 ? -39.669 28.798 -7.471  1.00 47.15  ? 135 MET A HE3  1 
ATOM   1932 N N    . LEU A 1 136 ? -44.840 24.190 -6.629  1.00 41.44  ? 136 LEU A N    1 
ATOM   1933 C CA   . LEU A 1 136 ? -44.811 22.889 -5.984  1.00 43.26  ? 136 LEU A CA   1 
ATOM   1934 C C    . LEU A 1 136 ? -45.240 21.861 -7.039  1.00 43.31  ? 136 LEU A C    1 
ATOM   1935 O O    . LEU A 1 136 ? -46.415 21.521 -7.183  1.00 41.59  ? 136 LEU A O    1 
ATOM   1936 C CB   . LEU A 1 136 ? -45.734 22.884 -4.770  1.00 42.85  ? 136 LEU A CB   1 
ATOM   1937 C CG   . LEU A 1 136 ? -45.482 21.591 -3.979  1.00 48.87  ? 136 LEU A CG   1 
ATOM   1938 C CD1  . LEU A 1 136 ? -44.290 21.723 -3.062  1.00 42.62  ? 136 LEU A CD1  1 
ATOM   1939 C CD2  . LEU A 1 136 ? -46.627 21.195 -3.122  1.00 40.71  ? 136 LEU A CD2  1 
ATOM   1940 H H    . LEU A 1 136 ? -45.598 24.593 -6.573  1.00 49.78  ? 136 LEU A H    1 
ATOM   1941 H HA   . LEU A 1 136 ? -43.914 22.676 -5.682  1.00 51.97  ? 136 LEU A HA   1 
ATOM   1942 H HB2  . LEU A 1 136 ? -45.543 23.648 -4.203  1.00 51.47  ? 136 LEU A HB2  1 
ATOM   1943 H HB3  . LEU A 1 136 ? -46.661 22.908 -5.056  1.00 51.47  ? 136 LEU A HB3  1 
ATOM   1944 H HG   . LEU A 1 136 ? -45.331 20.910 -4.653  1.00 58.70  ? 136 LEU A HG   1 
ATOM   1945 H HD11 . LEU A 1 136 ? -44.445 22.457 -2.447  1.00 51.19  ? 136 LEU A HD11 1 
ATOM   1946 H HD12 . LEU A 1 136 ? -44.178 20.896 -2.568  1.00 51.19  ? 136 LEU A HD12 1 
ATOM   1947 H HD13 . LEU A 1 136 ? -43.500 21.900 -3.595  1.00 51.19  ? 136 LEU A HD13 1 
ATOM   1948 H HD21 . LEU A 1 136 ? -46.448 20.323 -2.738  1.00 48.90  ? 136 LEU A HD21 1 
ATOM   1949 H HD22 . LEU A 1 136 ? -46.736 21.851 -2.416  1.00 48.90  ? 136 LEU A HD22 1 
ATOM   1950 H HD23 . LEU A 1 136 ? -47.430 21.158 -3.666  1.00 48.90  ? 136 LEU A HD23 1 
ATOM   1951 N N    . THR A 1 137 ? -44.267 21.359 -7.787  1.00 41.01  ? 137 THR A N    1 
ATOM   1952 C CA   . THR A 1 137 ? -44.514 20.435 -8.881  1.00 45.93  ? 137 THR A CA   1 
ATOM   1953 C C    . THR A 1 137 ? -44.360 18.983 -8.392  1.00 34.21  ? 137 THR A C    1 
ATOM   1954 O O    . THR A 1 137 ? -43.845 18.689 -7.299  1.00 32.23  ? 137 THR A O    1 
ATOM   1955 C CB   . THR A 1 137 ? -43.557 20.739 -10.056 1.00 39.12  ? 137 THR A CB   1 
ATOM   1956 O OG1  . THR A 1 137 ? -42.194 20.797 -9.585  1.00 44.71  ? 137 THR A OG1  1 
ATOM   1957 C CG2  . THR A 1 137 ? -43.976 21.997 -10.774 1.00 44.99  ? 137 THR A CG2  1 
ATOM   1958 H H    . THR A 1 137 ? -43.434 21.544 -7.676  1.00 49.27  ? 137 THR A H    1 
ATOM   1959 H HA   . THR A 1 137 ? -45.422 20.540 -9.205  1.00 55.16  ? 137 THR A HA   1 
ATOM   1960 H HB   . THR A 1 137 ? -43.597 20.028 -10.714 1.00 47.00  ? 137 THR A HB   1 
ATOM   1961 H HG1  . THR A 1 137 ? -41.870 21.557 -9.736  1.00 53.70  ? 137 THR A HG1  1 
ATOM   1962 H HG21 . THR A 1 137 ? -43.264 22.297 -11.361 1.00 54.03  ? 137 THR A HG21 1 
ATOM   1963 H HG22 . THR A 1 137 ? -44.170 22.697 -10.131 1.00 54.03  ? 137 THR A HG22 1 
ATOM   1964 H HG23 . THR A 1 137 ? -44.771 21.827 -11.304 1.00 54.03  ? 137 THR A HG23 1 
ATOM   1965 N N    . PHE A 1 138 ? -44.878 18.066 -9.213  1.00 40.62  ? 138 PHE A N    1 
ATOM   1966 C CA   . PHE A 1 138 ? -44.980 16.665 -8.831  1.00 38.45  ? 138 PHE A CA   1 
ATOM   1967 C C    . PHE A 1 138 ? -43.624 16.009 -8.630  1.00 42.00  ? 138 PHE A C    1 
ATOM   1968 O O    . PHE A 1 138 ? -43.577 14.920 -8.031  1.00 35.98  ? 138 PHE A O    1 
ATOM   1969 C CB   . PHE A 1 138 ? -45.768 15.881 -9.878  1.00 43.47  ? 138 PHE A CB   1 
ATOM   1970 C CG   . PHE A 1 138 ? -46.026 14.431 -9.479  1.00 41.75  ? 138 PHE A CG   1 
ATOM   1971 C CD1  . PHE A 1 138 ? -46.590 14.119 -8.260  1.00 44.95  ? 138 PHE A CD1  1 
ATOM   1972 C CD2  . PHE A 1 138 ? -45.716 13.390 -10.343 1.00 47.64  ? 138 PHE A CD2  1 
ATOM   1973 C CE1  . PHE A 1 138 ? -46.828 12.789 -7.941  1.00 47.14  ? 138 PHE A CE1  1 
ATOM   1974 C CE2  . PHE A 1 138 ? -45.930 12.085 -9.992  1.00 42.97  ? 138 PHE A CE2  1 
ATOM   1975 C CZ   . PHE A 1 138 ? -46.470 11.794 -8.804  1.00 46.26  ? 138 PHE A CZ   1 
ATOM   1976 H H    . PHE A 1 138 ? -45.178 18.235 -10.002 1.00 48.79  ? 138 PHE A H    1 
ATOM   1977 H HA   . PHE A 1 138 ? -45.467 16.618 -7.994  1.00 46.19  ? 138 PHE A HA   1 
ATOM   1978 H HB2  . PHE A 1 138 ? -46.628 16.311 -10.010 1.00 52.22  ? 138 PHE A HB2  1 
ATOM   1979 H HB3  . PHE A 1 138 ? -45.268 15.877 -10.709 1.00 52.22  ? 138 PHE A HB3  1 
ATOM   1980 H HD1  . PHE A 1 138 ? -46.810 14.793 -7.658  1.00 53.99  ? 138 PHE A HD1  1 
ATOM   1981 H HD2  . PHE A 1 138 ? -45.355 13.583 -11.178 1.00 57.22  ? 138 PHE A HD2  1 
ATOM   1982 H HE1  . PHE A 1 138 ? -47.234 12.575 -7.132  1.00 56.61  ? 138 PHE A HE1  1 
ATOM   1983 H HE2  . PHE A 1 138 ? -45.700 11.401 -10.579 1.00 51.61  ? 138 PHE A HE2  1 
ATOM   1984 H HZ   . PHE A 1 138 ? -46.604 10.905 -8.563  1.00 55.56  ? 138 PHE A HZ   1 
ATOM   1985 N N    . ASP A 1 139 ? -42.529 16.650 -9.090  1.00 41.99  ? 139 ASP A N    1 
ATOM   1986 C CA   . ASP A 1 139 ? -41.205 16.125 -8.795  1.00 37.41  ? 139 ASP A CA   1 
ATOM   1987 C C    . ASP A 1 139 ? -40.893 16.209 -7.315  1.00 43.50  ? 139 ASP A C    1 
ATOM   1988 O O    . ASP A 1 139 ? -39.884 15.645 -6.885  1.00 36.52  ? 139 ASP A O    1 
ATOM   1989 C CB   . ASP A 1 139 ? -40.116 16.822 -9.633  1.00 36.42  ? 139 ASP A CB   1 
ATOM   1990 C CG   . ASP A 1 139 ? -40.063 18.305 -9.457  1.00 45.32  ? 139 ASP A CG   1 
ATOM   1991 O OD1  . ASP A 1 139 ? -41.085 18.960 -9.107  1.00 44.87  ? 139 ASP A OD1  1 
ATOM   1992 O OD2  . ASP A 1 139 ? -38.978 18.837 -9.725  1.00 39.07  ? 139 ASP A OD2  1 
ATOM   1993 H H    . ASP A 1 139 ? -42.538 17.369 -9.561  1.00 50.44  ? 139 ASP A H    1 
ATOM   1994 H HA   . ASP A 1 139 ? -41.170 15.193 -9.062  1.00 44.94  ? 139 ASP A HA   1 
ATOM   1995 N N    . VAL A 1 140 ? -41.753 16.842 -6.507  1.00 38.96  ? 140 VAL A N    1 
ATOM   1996 C CA   . VAL A 1 140 ? -41.588 16.751 -5.056  1.00 36.57  ? 140 VAL A CA   1 
ATOM   1997 C C    . VAL A 1 140 ? -41.624 15.297 -4.586  1.00 47.08  ? 140 VAL A C    1 
ATOM   1998 O O    . VAL A 1 140 ? -41.149 14.974 -3.472  1.00 38.13  ? 140 VAL A O    1 
ATOM   1999 C CB   . VAL A 1 140 ? -42.676 17.591 -4.355  1.00 41.66  ? 140 VAL A CB   1 
ATOM   2000 C CG1  . VAL A 1 140 ? -44.037 16.947 -4.489  1.00 35.80  ? 140 VAL A CG1  1 
ATOM   2001 C CG2  . VAL A 1 140 ? -42.286 17.815 -2.894  1.00 39.37  ? 140 VAL A CG2  1 
ATOM   2002 H H    . VAL A 1 140 ? -42.420 17.317 -6.769  1.00 46.80  ? 140 VAL A H    1 
ATOM   2003 H HA   . VAL A 1 140 ? -40.723 17.117 -4.814  1.00 43.93  ? 140 VAL A HA   1 
ATOM   2004 H HB   . VAL A 1 140 ? -42.745 18.458 -4.784  1.00 50.05  ? 140 VAL A HB   1 
ATOM   2005 H HG11 . VAL A 1 140 ? -44.254 16.860 -5.430  1.00 43.01  ? 140 VAL A HG11 1 
ATOM   2006 H HG12 . VAL A 1 140 ? -44.695 17.506 -4.047  1.00 43.01  ? 140 VAL A HG12 1 
ATOM   2007 H HG13 . VAL A 1 140 ? -44.013 16.071 -4.072  1.00 43.01  ? 140 VAL A HG13 1 
ATOM   2008 H HG21 . VAL A 1 140 ? -41.322 17.899 -2.833  1.00 47.30  ? 140 VAL A HG21 1 
ATOM   2009 H HG22 . VAL A 1 140 ? -42.709 18.628 -2.575  1.00 47.30  ? 140 VAL A HG22 1 
ATOM   2010 H HG23 . VAL A 1 140 ? -42.586 17.058 -2.367  1.00 47.30  ? 140 VAL A HG23 1 
ATOM   2011 N N    . PHE A 1 141 ? -42.198 14.411 -5.406  1.00 40.81  ? 141 PHE A N    1 
ATOM   2012 C CA   . PHE A 1 141 ? -42.201 12.985 -5.130  1.00 46.90  ? 141 PHE A CA   1 
ATOM   2013 C C    . PHE A 1 141 ? -41.190 12.237 -5.970  1.00 40.93  ? 141 PHE A C    1 
ATOM   2014 O O    . PHE A 1 141 ? -41.138 11.010 -5.895  1.00 43.83  ? 141 PHE A O    1 
ATOM   2015 C CB   . PHE A 1 141 ? -43.604 12.401 -5.351  1.00 42.76  ? 141 PHE A CB   1 
ATOM   2016 C CG   . PHE A 1 141 ? -44.546 12.735 -4.254  1.00 42.48  ? 141 PHE A CG   1 
ATOM   2017 C CD1  . PHE A 1 141 ? -44.292 12.314 -2.961  1.00 45.33  ? 141 PHE A CD1  1 
ATOM   2018 C CD2  . PHE A 1 141 ? -45.668 13.488 -4.509  1.00 42.62  ? 141 PHE A CD2  1 
ATOM   2019 C CE1  . PHE A 1 141 ? -45.147 12.635 -1.946  1.00 46.60  ? 141 PHE A CE1  1 
ATOM   2020 C CE2  . PHE A 1 141 ? -46.537 13.816 -3.495  1.00 44.85  ? 141 PHE A CE2  1 
ATOM   2021 C CZ   . PHE A 1 141 ? -46.281 13.403 -2.218  1.00 33.86  ? 141 PHE A CZ   1 
ATOM   2022 H H    . PHE A 1 141 ? -42.596 14.622 -6.138  1.00 49.02  ? 141 PHE A H    1 
ATOM   2023 H HA   . PHE A 1 141 ? -41.974 12.851 -4.197  1.00 56.33  ? 141 PHE A HA   1 
ATOM   2024 H HB2  . PHE A 1 141 ? -43.967 12.758 -6.177  1.00 51.36  ? 141 PHE A HB2  1 
ATOM   2025 H HB3  . PHE A 1 141 ? -43.538 11.435 -5.407  1.00 51.36  ? 141 PHE A HB3  1 
ATOM   2026 H HD1  . PHE A 1 141 ? -43.532 11.808 -2.781  1.00 54.45  ? 141 PHE A HD1  1 
ATOM   2027 H HD2  . PHE A 1 141 ? -45.841 13.778 -5.375  1.00 51.20  ? 141 PHE A HD2  1 
ATOM   2028 H HE1  . PHE A 1 141 ? -44.975 12.344 -1.080  1.00 55.97  ? 141 PHE A HE1  1 
ATOM   2029 H HE2  . PHE A 1 141 ? -47.298 14.318 -3.678  1.00 53.87  ? 141 PHE A HE2  1 
ATOM   2030 H HZ   . PHE A 1 141 ? -46.862 13.633 -1.529  1.00 40.69  ? 141 PHE A HZ   1 
ATOM   2031 N N    . ARG A 1 142 ? -40.367 12.942 -6.744  1.00 45.66  ? 142 ARG A N    1 
ATOM   2032 C CA   . ARG A 1 142 ? -39.317 12.254 -7.485  1.00 39.65  ? 142 ARG A CA   1 
ATOM   2033 C C    . ARG A 1 142 ? -38.426 11.419 -6.588  1.00 44.75  ? 142 ARG A C    1 
ATOM   2034 O O    . ARG A 1 142 ? -38.098 10.284 -6.986  1.00 46.80  ? 142 ARG A O    1 
ATOM   2035 C CB   . ARG A 1 142 ? -38.452 13.235 -8.276  1.00 46.30  ? 142 ARG A CB   1 
ATOM   2036 C CG   . ARG A 1 142 ? -37.653 12.530 -9.347  1.00 47.42  ? 142 ARG A CG   1 
ATOM   2037 C CD   . ARG A 1 142 ? -36.516 13.409 -9.830  1.00 67.41  ? 142 ARG A CD   1 
ATOM   2038 N NE   . ARG A 1 142 ? -35.485 12.662 -10.547 1.00 72.63  ? 142 ARG A NE   1 
ATOM   2039 C CZ   . ARG A 1 142 ? -34.322 12.284 -10.025 1.00 78.16  ? 142 ARG A CZ   1 
ATOM   2040 N NH1  . ARG A 1 142 ? -34.013 12.569 -8.764  1.00 145.12 ? 142 ARG A NH1  1 
ATOM   2041 N NH2  . ARG A 1 142 ? -33.462 11.622 -10.775 1.00 74.51  ? 142 ARG A NH2  1 
ATOM   2042 H H    . ARG A 1 142 ? -40.396 13.794 -6.854  1.00 54.84  ? 142 ARG A H    1 
ATOM   2043 H HA   . ARG A 1 142 ? -39.765 11.680 -8.127  1.00 47.63  ? 142 ARG A HA   1 
ATOM   2044 H HB2  . ARG A 1 142 ? -39.022 13.893 -8.703  1.00 55.61  ? 142 ARG A HB2  1 
ATOM   2045 H HB3  . ARG A 1 142 ? -37.832 13.674 -7.672  1.00 55.61  ? 142 ARG A HB3  1 
ATOM   2046 H HG2  . ARG A 1 142 ? -37.279 11.711 -8.987  1.00 56.96  ? 142 ARG A HG2  1 
ATOM   2047 H HG3  . ARG A 1 142 ? -38.229 12.328 -10.101 1.00 56.96  ? 142 ARG A HG3  1 
ATOM   2048 H HD2  . ARG A 1 142 ? -36.871 14.083 -10.432 1.00 80.94  ? 142 ARG A HD2  1 
ATOM   2049 H HD3  . ARG A 1 142 ? -36.099 13.835 -9.064  1.00 80.94  ? 142 ARG A HD3  1 
ATOM   2050 H HE   . ARG A 1 142 ? -35.641 12.452 -11.366 1.00 87.21  ? 142 ARG A HE   1 
ATOM   2051 H HH11 . ARG A 1 142 ? -34.568 13.005 -8.273  1.00 174.19 ? 142 ARG A HH11 1 
ATOM   2052 H HH12 . ARG A 1 142 ? -33.257 12.318 -8.440  1.00 174.19 ? 142 ARG A HH12 1 
ATOM   2053 H HH21 . ARG A 1 142 ? -33.656 11.440 -11.593 1.00 89.46  ? 142 ARG A HH21 1 
ATOM   2054 H HH22 . ARG A 1 142 ? -32.707 11.373 -10.447 1.00 89.46  ? 142 ARG A HH22 1 
ATOM   2055 N N    . PRO A 1 143 ? -38.022 11.846 -5.395  1.00 46.75  ? 143 PRO A N    1 
ATOM   2056 C CA   . PRO A 1 143 ? -37.119 10.997 -4.599  1.00 44.81  ? 143 PRO A CA   1 
ATOM   2057 C C    . PRO A 1 143 ? -37.696 9.610  -4.275  1.00 51.71  ? 143 PRO A C    1 
ATOM   2058 O O    . PRO A 1 143 ? -36.922 8.674  -4.058  1.00 49.72  ? 143 PRO A O    1 
ATOM   2059 C CB   . PRO A 1 143 ? -36.864 11.827 -3.333  1.00 46.17  ? 143 PRO A CB   1 
ATOM   2060 C CG   . PRO A 1 143 ? -37.169 13.278 -3.770  1.00 46.41  ? 143 PRO A CG   1 
ATOM   2061 C CD   . PRO A 1 143 ? -38.302 13.147 -4.731  1.00 43.70  ? 143 PRO A CD   1 
ATOM   2062 H HA   . PRO A 1 143 ? -36.277 10.882 -5.067  1.00 53.83  ? 143 PRO A HA   1 
ATOM   2063 H HB2  . PRO A 1 143 ? -37.459 11.543 -2.622  1.00 55.45  ? 143 PRO A HB2  1 
ATOM   2064 H HB3  . PRO A 1 143 ? -35.941 11.732 -3.052  1.00 55.45  ? 143 PRO A HB3  1 
ATOM   2065 H HG2  . PRO A 1 143 ? -37.424 13.810 -3.000  1.00 55.74  ? 143 PRO A HG2  1 
ATOM   2066 H HG3  . PRO A 1 143 ? -36.390 13.666 -4.199  1.00 55.74  ? 143 PRO A HG3  1 
ATOM   2067 H HD2  . PRO A 1 143 ? -39.152 13.123 -4.265  1.00 52.50  ? 143 PRO A HD2  1 
ATOM   2068 H HD3  . PRO A 1 143 ? -38.297 13.874 -5.374  1.00 52.50  ? 143 PRO A HD3  1 
ATOM   2069 N N    . LEU A 1 144 ? -39.024 9.422  -4.273  1.00 55.77  ? 144 LEU A N    1 
ATOM   2070 C CA   . LEU A 1 144 ? -39.548 8.100  -3.934  1.00 57.48  ? 144 LEU A CA   1 
ATOM   2071 C C    . LEU A 1 144 ? -39.372 7.071  -5.052  1.00 59.77  ? 144 LEU A C    1 
ATOM   2072 O O    . LEU A 1 144 ? -39.376 5.871  -4.770  1.00 56.73  ? 144 LEU A O    1 
ATOM   2073 C CB   . LEU A 1 144 ? -41.019 8.202  -3.559  1.00 49.84  ? 144 LEU A CB   1 
ATOM   2074 C CG   . LEU A 1 144 ? -41.326 9.088  -2.345  1.00 52.74  ? 144 LEU A CG   1 
ATOM   2075 C CD1  . LEU A 1 144 ? -42.806 9.063  -1.986  1.00 53.08  ? 144 LEU A CD1  1 
ATOM   2076 C CD2  . LEU A 1 144 ? -40.462 8.655  -1.184  1.00 51.46  ? 144 LEU A CD2  1 
ATOM   2077 H H    . LEU A 1 144 ? -39.614 10.020 -4.457  1.00 66.98  ? 144 LEU A H    1 
ATOM   2078 H HA   . LEU A 1 144 ? -39.055 7.775  -3.165  1.00 69.03  ? 144 LEU A HA   1 
ATOM   2079 H HB2  . LEU A 1 144 ? -41.502 8.569  -4.315  1.00 59.86  ? 144 LEU A HB2  1 
ATOM   2080 H HB3  . LEU A 1 144 ? -41.345 7.311  -3.357  1.00 59.86  ? 144 LEU A HB3  1 
ATOM   2081 H HG   . LEU A 1 144 ? -41.121 10.011 -2.558  1.00 63.34  ? 144 LEU A HG   1 
ATOM   2082 H HD11 . LEU A 1 144 ? -42.962 9.671  -1.247  1.00 63.75  ? 144 LEU A HD11 1 
ATOM   2083 H HD12 . LEU A 1 144 ? -43.323 9.341  -2.759  1.00 63.75  ? 144 LEU A HD12 1 
ATOM   2084 H HD13 . LEU A 1 144 ? -43.053 8.160  -1.730  1.00 63.75  ? 144 LEU A HD13 1 
ATOM   2085 H HD21 . LEU A 1 144 ? -39.581 9.050  -1.281  1.00 61.80  ? 144 LEU A HD21 1 
ATOM   2086 H HD22 . LEU A 1 144 ? -40.393 7.688  -1.184  1.00 61.80  ? 144 LEU A HD22 1 
ATOM   2087 H HD23 . LEU A 1 144 ? -40.869 8.957  -0.357  1.00 61.80  ? 144 LEU A HD23 1 
ATOM   2088 N N    . PHE A 1 145 ? -39.188 7.499  -6.302  1.00 60.81  ? 145 PHE A N    1 
ATOM   2089 C CA   . PHE A 1 145 ? -38.949 6.547  -7.383  1.00 56.57  ? 145 PHE A CA   1 
ATOM   2090 C C    . PHE A 1 145 ? -37.591 5.887  -7.251  1.00 69.56  ? 145 PHE A C    1 
ATOM   2091 O O    . PHE A 1 145 ? -37.498 4.662  -7.129  1.00 75.82  ? 145 PHE A O    1 
ATOM   2092 C CB   . PHE A 1 145 ? -39.071 7.236  -8.716  1.00 52.39  ? 145 PHE A CB   1 
ATOM   2093 C CG   . PHE A 1 145 ? -40.455 7.579  -9.047  1.00 52.89  ? 145 PHE A CG   1 
ATOM   2094 C CD1  . PHE A 1 145 ? -41.136 8.520  -8.302  1.00 55.35  ? 145 PHE A CD1  1 
ATOM   2095 C CD2  . PHE A 1 145 ? -41.114 6.919  -10.066 1.00 58.53  ? 145 PHE A CD2  1 
ATOM   2096 C CE1  . PHE A 1 145 ? -42.449 8.839  -8.609  1.00 55.76  ? 145 PHE A CE1  1 
ATOM   2097 C CE2  . PHE A 1 145 ? -42.426 7.218  -10.364 1.00 63.71  ? 145 PHE A CE2  1 
ATOM   2098 C CZ   . PHE A 1 145 ? -43.095 8.188  -9.636  1.00 59.50  ? 145 PHE A CZ   1 
ATOM   2099 H H    . PHE A 1 145 ? -39.196 8.323  -6.546  1.00 73.03  ? 145 PHE A H    1 
ATOM   2100 H HA   . PHE A 1 145 ? -39.627 5.854  -7.334  1.00 67.93  ? 145 PHE A HA   1 
ATOM   2101 H HB2  . PHE A 1 145 ? -38.554 8.056  -8.697  1.00 62.92  ? 145 PHE A HB2  1 
ATOM   2102 H HB3  . PHE A 1 145 ? -38.733 6.646  -9.409  1.00 62.92  ? 145 PHE A HB3  1 
ATOM   2103 H HD1  . PHE A 1 145 ? -40.712 8.942  -7.591  1.00 66.47  ? 145 PHE A HD1  1 
ATOM   2104 H HD2  . PHE A 1 145 ? -40.668 6.267  -10.556 1.00 70.29  ? 145 PHE A HD2  1 
ATOM   2105 H HE1  . PHE A 1 145 ? -42.895 9.493  -8.120  1.00 66.96  ? 145 PHE A HE1  1 
ATOM   2106 H HE2  . PHE A 1 145 ? -42.861 6.769  -11.052 1.00 76.50  ? 145 PHE A HE2  1 
ATOM   2107 H HZ   . PHE A 1 145 ? -43.977 8.400  -9.841  1.00 71.45  ? 145 PHE A HZ   1 
ATOM   2108 N N    . ASP A 1 146 ? -36.525 6.681  -7.239  1.00 70.75  ? 146 ASP A N    1 
ATOM   2109 C CA   . ASP A 1 146 ? -35.197 6.119  -7.028  1.00 76.69  ? 146 ASP A CA   1 
ATOM   2110 C C    . ASP A 1 146 ? -34.932 5.901  -5.544  1.00 78.00  ? 146 ASP A C    1 
ATOM   2111 O O    . ASP A 1 146 ? -33.783 6.011  -5.097  1.00 74.86  ? 146 ASP A O    1 
ATOM   2112 C CB   . ASP A 1 146 ? -34.102 6.995  -7.651  1.00 91.52  ? 146 ASP A CB   1 
ATOM   2113 C CG   . ASP A 1 146 ? -34.223 8.462  -7.253  1.00 94.39  ? 146 ASP A CG   1 
ATOM   2114 O OD1  . ASP A 1 146 ? -35.232 8.819  -6.612  1.00 79.64  ? 146 ASP A OD1  1 
ATOM   2115 O OD2  . ASP A 1 146 ? -33.323 9.260  -7.604  1.00 129.17 ? 146 ASP A OD2  1 
ATOM   2116 H H    . ASP A 1 146 ? -36.545 7.534  -7.349  1.00 84.94  ? 146 ASP A H    1 
ATOM   2117 H HA   . ASP A 1 146 ? -35.158 5.258  -7.473  1.00 92.08  ? 146 ASP A HA   1 
ATOM   2118 H HB2  . ASP A 1 146 ? -33.235 6.675  -7.356  1.00 109.88 ? 146 ASP A HB2  1 
ATOM   2119 H HB3  . ASP A 1 146 ? -34.165 6.940  -8.617  1.00 109.88 ? 146 ASP A HB3  1 
ATOM   2120 N N    . PHE A 1 147 ? -35.967 5.581  -4.759  1.00 71.14  ? 147 PHE A N    1 
ATOM   2121 C CA   . PHE A 1 147 ? -35.765 5.148  -3.361  1.00 68.03  ? 147 PHE A CA   1 
ATOM   2122 C C    . PHE A 1 147 ? -35.530 3.646  -3.402  1.00 65.06  ? 147 PHE A C    1 
ATOM   2123 O O    . PHE A 1 147 ? -36.122 2.988  -4.260  1.00 58.98  ? 147 PHE A O    1 
ATOM   2124 C CB   . PHE A 1 147 ? -36.956 5.412  -2.455  1.00 58.74  ? 147 PHE A CB   1 
ATOM   2125 C CG   . PHE A 1 147 ? -36.660 5.172  -1.001  1.00 60.86  ? 147 PHE A CG   1 
ATOM   2126 C CD1  . PHE A 1 147 ? -36.011 6.128  -0.243  1.00 49.97  ? 147 PHE A CD1  1 
ATOM   2127 C CD2  . PHE A 1 147 ? -36.996 3.971  -0.405  1.00 62.09  ? 147 PHE A CD2  1 
ATOM   2128 C CE1  . PHE A 1 147 ? -35.730 5.898  1.091   1.00 54.88  ? 147 PHE A CE1  1 
ATOM   2129 C CE2  . PHE A 1 147 ? -36.709 3.741  0.927   1.00 57.42  ? 147 PHE A CE2  1 
ATOM   2130 C CZ   . PHE A 1 147 ? -36.081 4.704  1.672   1.00 59.58  ? 147 PHE A CZ   1 
ATOM   2131 H H    . PHE A 1 147 ? -36.836 5.690  -4.954  1.00 85.42  ? 147 PHE A H    1 
ATOM   2132 H HA   . PHE A 1 147 ? -34.968 5.592  -2.982  1.00 81.69  ? 147 PHE A HA   1 
ATOM   2133 H HB2  . PHE A 1 147 ? -37.240 6.342  -2.576  1.00 70.54  ? 147 PHE A HB2  1 
ATOM   2134 H HB3  . PHE A 1 147 ? -37.694 4.831  -2.731  1.00 70.54  ? 147 PHE A HB3  1 
ATOM   2135 H HD1  . PHE A 1 147 ? -35.768 6.951  -0.639  1.00 60.02  ? 147 PHE A HD1  1 
ATOM   2136 H HD2  . PHE A 1 147 ? -37.431 3.306  -0.914  1.00 74.56  ? 147 PHE A HD2  1 
ATOM   2137 H HE1  . PHE A 1 147 ? -35.296 6.562  1.602   1.00 65.91  ? 147 PHE A HE1  1 
ATOM   2138 H HE2  . PHE A 1 147 ? -36.957 2.923  1.327   1.00 68.95  ? 147 PHE A HE2  1 
ATOM   2139 H HZ   . PHE A 1 147 ? -35.896 4.547  2.582   1.00 71.54  ? 147 PHE A HZ   1 
ATOM   2140 N N    . VAL A 1 148 ? -34.699 3.150  -2.508  1.00 66.45  ? 148 VAL A N    1 
ATOM   2141 C CA   . VAL A 1 148 ? -34.388 1.710  -2.390  1.00 62.85  ? 148 VAL A CA   1 
ATOM   2142 C C    . VAL A 1 148 ? -34.170 1.421  -0.916  1.00 67.12  ? 148 VAL A C    1 
ATOM   2143 O O    . VAL A 1 148 ? -35.082 0.868  -0.322  1.00 71.14  ? 148 VAL A O    1 
ATOM   2144 C CB   . VAL A 1 148 ? -33.158 1.348  -3.225  1.00 30.00  ? 148 VAL A CB   1 
ATOM   2145 H H    . VAL A 1 148 ? -34.296 3.660  -1.882  1.00 79.79  ? 148 VAL A H    1 
ATOM   2146 H HA   . VAL A 1 148 ? -35.150 1.192  -2.702  1.00 75.47  ? 148 VAL A HA   1 
ATOM   2147 N N    . ASN A 1 149 ? -33.054 1.847  -0.346  1.00 66.55  ? 149 ASN A N    1 
ATOM   2148 C CA   . ASN A 1 149 ? -32.702 1.524  1.049   1.00 75.96  ? 149 ASN A CA   1 
ATOM   2149 C C    . ASN A 1 149 ? -32.055 2.712  1.744   1.00 81.69  ? 149 ASN A C    1 
ATOM   2150 O O    . ASN A 1 149 ? -31.301 2.489  2.709   1.00 82.04  ? 149 ASN A O    1 
ATOM   2151 C CB   . ASN A 1 149 ? -31.729 0.351  1.089   1.00 94.44  ? 149 ASN A CB   1 
ATOM   2152 C CG   . ASN A 1 149 ? -31.801 -0.444 2.374   1.00 91.44  ? 149 ASN A CG   1 
ATOM   2153 O OD1  . ASN A 1 149 ? -32.825 -1.048 2.681   1.00 97.45  ? 149 ASN A OD1  1 
ATOM   2154 N ND2  . ASN A 1 149 ? -30.719 -0.443 3.132   1.00 86.51  ? 149 ASN A ND2  1 
ATOM   2155 H H    . ASN A 1 149 ? -32.443 2.366  -0.776  1.00 79.91  ? 149 ASN A H    1 
ATOM   2156 H HA   . ASN A 1 149 ? -33.514 1.272  1.541   1.00 91.21  ? 149 ASN A HA   1 
ATOM   2157 H HB2  . ASN A 1 149 ? -31.929 -0.244 0.339   1.00 113.38 ? 149 ASN A HB2  1 
ATOM   2158 H HB3  . ASN A 1 149 ? -30.818 0.687  0.969   1.00 113.38 ? 149 ASN A HB3  1 
ATOM   2159 H HD21 . ASN A 1 149 ? -29.936 -0.229 2.784   1.00 103.87 ? 149 ASN A HD21 1 
ATOM   2160 H HD22 . ASN A 1 149 ? -30.781 -0.649 3.990   1.00 103.87 ? 149 ASN A HD22 1 
ATOM   2161 N N    . GLU A 1 150 ? -32.379 3.926  1.325   1.00 79.74  ? 150 GLU A N    1 
ATOM   2162 C CA   . GLU A 1 150 ? -31.729 5.134  1.884   1.00 68.73  ? 150 GLU A CA   1 
ATOM   2163 C C    . GLU A 1 150 ? -32.392 5.495  3.214   1.00 63.60  ? 150 GLU A C    1 
ATOM   2164 O O    . GLU A 1 150 ? -33.588 5.282  3.350   1.00 63.14  ? 150 GLU A O    1 
ATOM   2165 C CB   . GLU A 1 150 ? -31.707 6.231  0.824   1.00 62.63  ? 150 GLU A CB   1 
ATOM   2166 C CG   . GLU A 1 150 ? -30.964 5.840  -0.436  1.00 57.68  ? 150 GLU A CG   1 
ATOM   2167 C CD   . GLU A 1 150 ? -31.811 5.187  -1.511  1.00 60.47  ? 150 GLU A CD   1 
ATOM   2168 O OE1  . GLU A 1 150 ? -31.317 5.006  -2.632  1.00 62.88  ? 150 GLU A OE1  1 
ATOM   2169 O OE2  . GLU A 1 150 ? -32.963 4.871  -1.226  1.00 67.58  ? 150 GLU A OE2  1 
ATOM   2170 H H    . GLU A 1 150 ? -33.037 4.088  0.717   1.00 95.74  ? 150 GLU A H    1 
ATOM   2171 H HA   . GLU A 1 150 ? -30.794 4.902  2.076   1.00 82.53  ? 150 GLU A HA   1 
ATOM   2172 H HB2  . GLU A 1 150 ? -32.629 6.475  0.600   1.00 75.21  ? 150 GLU A HB2  1 
ATOM   2173 H HB3  . GLU A 1 150 ? -31.277 7.023  1.209   1.00 75.21  ? 150 GLU A HB3  1 
ATOM   2174 H HG2  . GLU A 1 150 ? -30.550 6.643  -0.817  1.00 69.26  ? 150 GLU A HG2  1 
ATOM   2175 H HG3  . GLU A 1 150 ? -30.242 5.222  -0.195  1.00 69.26  ? 150 GLU A HG3  1 
ATOM   2176 N N    . LYS A 1 151 ? -31.624 5.950  4.175   1.00 55.11  ? 151 LYS A N    1 
ATOM   2177 C CA   . LYS A 1 151 ? -32.026 6.344  5.524   1.00 59.89  ? 151 LYS A CA   1 
ATOM   2178 C C    . LYS A 1 151 ? -32.795 7.657  5.550   1.00 56.03  ? 151 LYS A C    1 
ATOM   2179 O O    . LYS A 1 151 ? -33.610 7.891  6.458   1.00 54.12  ? 151 LYS A O    1 
ATOM   2180 C CB   . LYS A 1 151 ? -30.744 6.460  6.324   1.00 53.63  ? 151 LYS A CB   1 
ATOM   2181 C CG   . LYS A 1 151 ? -30.754 6.850  7.740   1.00 56.09  ? 151 LYS A CG   1 
ATOM   2182 C CD   . LYS A 1 151 ? -29.284 7.258  8.048   1.00 69.25  ? 151 LYS A CD   1 
ATOM   2183 C CE   . LYS A 1 151 ? -28.272 6.144  7.564   1.00 75.60  ? 151 LYS A CE   1 
ATOM   2184 N NZ   . LYS A 1 151 ? -26.851 6.629  7.337   1.00 79.38  ? 151 LYS A NZ   1 
ATOM   2185 H H    . LYS A 1 151 ? -30.786 6.091  4.042   1.00 66.18  ? 151 LYS A H    1 
ATOM   2186 H HA   . LYS A 1 151 ? -32.621 5.683  5.913   1.00 71.92  ? 151 LYS A HA   1 
ATOM   2187 H HB2  . LYS A 1 151 ? -30.315 5.591  6.295   1.00 64.41  ? 151 LYS A HB2  1 
ATOM   2188 H HB3  . LYS A 1 151 ? -30.192 7.119  5.875   1.00 64.41  ? 151 LYS A HB3  1 
ATOM   2189 H HG2  . LYS A 1 151 ? -31.347 7.604  7.888   1.00 67.36  ? 151 LYS A HG2  1 
ATOM   2190 H HG3  . LYS A 1 151 ? -31.018 6.106  8.303   1.00 67.36  ? 151 LYS A HG3  1 
ATOM   2191 H HD2  . LYS A 1 151 ? -29.074 8.085  7.585   1.00 83.16  ? 151 LYS A HD2  1 
ATOM   2192 H HD3  . LYS A 1 151 ? -29.175 7.377  9.004   1.00 83.16  ? 151 LYS A HD3  1 
ATOM   2193 H HE2  . LYS A 1 151 ? -28.238 5.446  8.237   1.00 90.77  ? 151 LYS A HE2  1 
ATOM   2194 H HE3  . LYS A 1 151 ? -28.593 5.780  6.724   1.00 90.77  ? 151 LYS A HE3  1 
ATOM   2195 H HZ1  . LYS A 1 151 ? -26.367 5.987  6.956   1.00 95.30  ? 151 LYS A HZ1  1 
ATOM   2196 H HZ2  . LYS A 1 151 ? -26.855 7.342  6.804   1.00 95.30  ? 151 LYS A HZ2  1 
ATOM   2197 H HZ3  . LYS A 1 151 ? -26.477 6.851  8.113   1.00 95.30  ? 151 LYS A HZ3  1 
ATOM   2198 N N    . TYR A 1 152 ? -32.523 8.532  4.586   1.00 51.61  ? 152 TYR A N    1 
ATOM   2199 C CA   . TYR A 1 152 ? -33.070 9.880  4.576   1.00 51.59  ? 152 TYR A CA   1 
ATOM   2200 C C    . TYR A 1 152 ? -33.700 10.162 3.232   1.00 53.81  ? 152 TYR A C    1 
ATOM   2201 O O    . TYR A 1 152 ? -33.165 9.756  2.190   1.00 51.91  ? 152 TYR A O    1 
ATOM   2202 C CB   . TYR A 1 152 ? -32.005 10.927 4.826   1.00 48.58  ? 152 TYR A CB   1 
ATOM   2203 C CG   . TYR A 1 152 ? -31.468 10.917 6.205   1.00 50.49  ? 152 TYR A CG   1 
ATOM   2204 C CD1  . TYR A 1 152 ? -32.234 11.356 7.248   1.00 48.51  ? 152 TYR A CD1  1 
ATOM   2205 C CD2  . TYR A 1 152 ? -30.196 10.450 6.477   1.00 59.25  ? 152 TYR A CD2  1 
ATOM   2206 C CE1  . TYR A 1 152 ? -31.770 11.351 8.524   1.00 47.75  ? 152 TYR A CE1  1 
ATOM   2207 C CE2  . TYR A 1 152 ? -29.709 10.450 7.766   1.00 56.30  ? 152 TYR A CE2  1 
ATOM   2208 C CZ   . TYR A 1 152 ? -30.508 10.895 8.792   1.00 60.10  ? 152 TYR A CZ   1 
ATOM   2209 O OH   . TYR A 1 152 ? -30.052 10.905 10.104  1.00 57.17  ? 152 TYR A OH   1 
ATOM   2210 H H    . TYR A 1 152 ? -32.013 8.362  3.915   1.00 61.99  ? 152 TYR A H    1 
ATOM   2211 H HA   . TYR A 1 152 ? -33.743 9.941  5.271   1.00 61.96  ? 152 TYR A HA   1 
ATOM   2212 H HB2  . TYR A 1 152 ? -31.264 10.770 4.219   1.00 58.34  ? 152 TYR A HB2  1 
ATOM   2213 H HB3  . TYR A 1 152 ? -32.386 11.804 4.663   1.00 58.34  ? 152 TYR A HB3  1 
ATOM   2214 H HD1  . TYR A 1 152 ? -33.095 11.665 7.080   1.00 58.26  ? 152 TYR A HD1  1 
ATOM   2215 H HD2  . TYR A 1 152 ? -29.664 10.132 5.783   1.00 71.15  ? 152 TYR A HD2  1 
ATOM   2216 H HE1  . TYR A 1 152 ? -32.310 11.658 9.216   1.00 57.35  ? 152 TYR A HE1  1 
ATOM   2217 H HE2  . TYR A 1 152 ? -28.846 10.151 7.940   1.00 67.62  ? 152 TYR A HE2  1 
ATOM   2218 H HH   . TYR A 1 152 ? -29.246 10.672 10.129  1.00 68.66  ? 152 TYR A HH   1 
ATOM   2219 N N    . CYS A 1 153 ? -34.824 10.882 3.272   1.00 48.07  ? 153 CYS A N    1 
ATOM   2220 C CA   . CYS A 1 153 ? -35.366 11.589 2.122   1.00 44.47  ? 153 CYS A CA   1 
ATOM   2221 C C    . CYS A 1 153 ? -35.425 13.078 2.474   1.00 50.58  ? 153 CYS A C    1 
ATOM   2222 O O    . CYS A 1 153 ? -36.166 13.480 3.388   1.00 47.47  ? 153 CYS A O    1 
ATOM   2223 C CB   . CYS A 1 153 ? -36.731 11.014 1.757   1.00 37.51  ? 153 CYS A CB   1 
ATOM   2224 S SG   . CYS A 1 153 ? -37.551 11.923 0.472   1.00 44.06  ? 153 CYS A SG   1 
ATOM   2225 H H    . CYS A 1 153 ? -35.302 10.976 3.980   1.00 57.73  ? 153 CYS A H    1 
ATOM   2226 H HA   . CYS A 1 153 ? -34.788 11.498 1.349   1.00 53.42  ? 153 CYS A HA   1 
ATOM   2227 H HB2  . CYS A 1 153 ? -36.615 10.101 1.450   1.00 45.06  ? 153 CYS A HB2  1 
ATOM   2228 H HB3  . CYS A 1 153 ? -37.299 11.030 2.543   1.00 45.06  ? 153 CYS A HB3  1 
ATOM   2229 H HG   . CYS A 1 153 ? -38.564 11.352 0.175   1.00 52.92  ? 153 CYS A HG   1 
ATOM   2230 N N    . ILE A 1 154 ? -34.618 13.886 1.774   1.00 46.41  ? 154 ILE A N    1 
ATOM   2231 C CA   . ILE A 1 154 ? -34.432 15.308 2.055   1.00 44.10  ? 154 ILE A CA   1 
ATOM   2232 C C    . ILE A 1 154 ? -35.009 16.083 0.894   1.00 46.24  ? 154 ILE A C    1 
ATOM   2233 O O    . ILE A 1 154 ? -34.611 15.874 -0.263  1.00 42.11  ? 154 ILE A O    1 
ATOM   2234 C CB   . ILE A 1 154 ? -32.955 15.666 2.240   1.00 46.25  ? 154 ILE A CB   1 
ATOM   2235 C CG1  . ILE A 1 154 ? -32.338 14.742 3.258   1.00 48.15  ? 154 ILE A CG1  1 
ATOM   2236 C CG2  . ILE A 1 154 ? -32.740 17.115 2.688   1.00 45.30  ? 154 ILE A CG2  1 
ATOM   2237 C CD1  . ILE A 1 154 ? -30.806 14.875 3.307   1.00 56.33  ? 154 ILE A CD1  1 
ATOM   2238 H H    . ILE A 1 154 ? -34.150 13.617 1.104   1.00 55.74  ? 154 ILE A H    1 
ATOM   2239 H HA   . ILE A 1 154 ? -34.913 15.534 2.867   1.00 52.97  ? 154 ILE A HA   1 
ATOM   2240 H HB   . ILE A 1 154 ? -32.534 15.562 1.372   1.00 55.55  ? 154 ILE A HB   1 
ATOM   2241 H HG12 . ILE A 1 154 ? -32.689 14.957 4.137   1.00 57.83  ? 154 ILE A HG12 1 
ATOM   2242 H HG13 . ILE A 1 154 ? -32.555 13.825 3.029   1.00 57.83  ? 154 ILE A HG13 1 
ATOM   2243 H HG21 . ILE A 1 154 ? -33.257 17.703 2.115   1.00 54.42  ? 154 ILE A HG21 1 
ATOM   2244 H HG22 . ILE A 1 154 ? -31.797 17.330 2.619   1.00 54.42  ? 154 ILE A HG22 1 
ATOM   2245 H HG23 . ILE A 1 154 ? -33.034 17.208 3.608   1.00 54.42  ? 154 ILE A HG23 1 
ATOM   2246 H HD11 . ILE A 1 154 ? -30.449 14.197 3.902   1.00 67.65  ? 154 ILE A HD11 1 
ATOM   2247 H HD12 . ILE A 1 154 ? -30.450 14.753 2.413   1.00 67.65  ? 154 ILE A HD12 1 
ATOM   2248 H HD13 . ILE A 1 154 ? -30.576 15.758 3.637   1.00 67.65  ? 154 ILE A HD13 1 
ATOM   2249 N N    . ILE A 1 155 ? -35.951 16.973 1.188   1.00 39.70  ? 155 ILE A N    1 
ATOM   2250 C CA   . ILE A 1 155 ? -36.529 17.787 0.151   1.00 37.52  ? 155 ILE A CA   1 
ATOM   2251 C C    . ILE A 1 155 ? -36.430 19.259 0.542   1.00 43.67  ? 155 ILE A C    1 
ATOM   2252 O O    . ILE A 1 155 ? -36.792 19.651 1.665   1.00 39.39  ? 155 ILE A O    1 
ATOM   2253 C CB   . ILE A 1 155 ? -37.962 17.358 -0.132  1.00 37.65  ? 155 ILE A CB   1 
ATOM   2254 C CG1  . ILE A 1 155 ? -37.908 15.911 -0.629  1.00 36.01  ? 155 ILE A CG1  1 
ATOM   2255 C CG2  . ILE A 1 155 ? -38.548 18.255 -1.166  1.00 43.34  ? 155 ILE A CG2  1 
ATOM   2256 C CD1  . ILE A 1 155 ? -39.217 15.404 -1.077  1.00 47.23  ? 155 ILE A CD1  1 
ATOM   2257 H H    . ILE A 1 155 ? -36.262 17.115 1.977   1.00 47.69  ? 155 ILE A H    1 
ATOM   2258 H HA   . ILE A 1 155 ? -36.015 17.696 -0.667  1.00 45.07  ? 155 ILE A HA   1 
ATOM   2259 H HB   . ILE A 1 155 ? -38.514 17.417 0.663   1.00 45.23  ? 155 ILE A HB   1 
ATOM   2260 H HG12 . ILE A 1 155 ? -37.295 15.859 -1.379  1.00 43.27  ? 155 ILE A HG12 1 
ATOM   2261 H HG13 . ILE A 1 155 ? -37.599 15.342 0.093   1.00 43.27  ? 155 ILE A HG13 1 
ATOM   2262 H HG21 . ILE A 1 155 ? -38.540 19.167 -0.834  1.00 52.06  ? 155 ILE A HG21 1 
ATOM   2263 H HG22 . ILE A 1 155 ? -39.460 17.977 -1.345  1.00 52.06  ? 155 ILE A HG22 1 
ATOM   2264 H HG23 . ILE A 1 155 ? -38.018 18.193 -1.976  1.00 52.06  ? 155 ILE A HG23 1 
ATOM   2265 H HD11 . ILE A 1 155 ? -39.310 14.480 -0.798  1.00 56.72  ? 155 ILE A HD11 1 
ATOM   2266 H HD12 . ILE A 1 155 ? -39.264 15.464 -2.044  1.00 56.72  ? 155 ILE A HD12 1 
ATOM   2267 H HD13 . ILE A 1 155 ? -39.918 15.943 -0.678  1.00 56.72  ? 155 ILE A HD13 1 
ATOM   2268 N N    . LYS A 1 156 ? -35.914 20.077 -0.370  1.00 39.18  ? 156 LYS A N    1 
ATOM   2269 C CA   . LYS A 1 156 ? -36.013 21.524 -0.202  1.00 39.54  ? 156 LYS A CA   1 
ATOM   2270 C C    . LYS A 1 156 ? -37.300 21.979 -0.872  1.00 39.62  ? 156 LYS A C    1 
ATOM   2271 O O    . LYS A 1 156 ? -37.438 21.949 -2.103  1.00 37.92  ? 156 LYS A O    1 
ATOM   2272 C CB   . LYS A 1 156 ? -34.807 22.259 -0.762  1.00 38.87  ? 156 LYS A CB   1 
ATOM   2273 C CG   . LYS A 1 156 ? -34.859 23.760 -0.430  1.00 35.17  ? 156 LYS A CG   1 
ATOM   2274 C CD   . LYS A 1 156 ? -33.527 24.495 -0.643  1.00 39.93  ? 156 LYS A CD   1 
ATOM   2275 C CE   . LYS A 1 156 ? -33.495 25.899 -0.016  1.00 36.53  ? 156 LYS A CE   1 
ATOM   2276 N NZ   . LYS A 1 156 ? -32.170 26.562 -0.189  1.00 52.87  ? 156 LYS A NZ   1 
ATOM   2277 H H    . LYS A 1 156 ? -35.507 19.822 -1.083  1.00 47.06  ? 156 LYS A H    1 
ATOM   2278 H HA   . LYS A 1 156 ? -36.046 21.729 0.746   1.00 47.50  ? 156 LYS A HA   1 
ATOM   2279 H HB2  . LYS A 1 156 ? -33.998 21.888 -0.377  1.00 46.70  ? 156 LYS A HB2  1 
ATOM   2280 H HB3  . LYS A 1 156 ? -34.791 22.159 -1.727  1.00 46.70  ? 156 LYS A HB3  1 
ATOM   2281 H HG2  . LYS A 1 156 ? -35.522 24.183 -0.999  1.00 42.26  ? 156 LYS A HG2  1 
ATOM   2282 H HG3  . LYS A 1 156 ? -35.107 23.865 0.502   1.00 42.26  ? 156 LYS A HG3  1 
ATOM   2283 H HD2  . LYS A 1 156 ? -32.814 23.974 -0.241  1.00 47.97  ? 156 LYS A HD2  1 
ATOM   2284 H HD3  . LYS A 1 156 ? -33.371 24.592 -1.595  1.00 47.97  ? 156 LYS A HD3  1 
ATOM   2285 H HE2  . LYS A 1 156 ? -34.168 26.453 -0.441  1.00 43.88  ? 156 LYS A HE2  1 
ATOM   2286 H HE3  . LYS A 1 156 ? -33.675 25.828 0.934   1.00 43.88  ? 156 LYS A HE3  1 
ATOM   2287 H HZ1  . LYS A 1 156 ? -31.981 26.645 -1.055  1.00 63.50  ? 156 LYS A HZ1  1 
ATOM   2288 H HZ2  . LYS A 1 156 ? -32.183 27.371 0.182   1.00 63.50  ? 156 LYS A HZ2  1 
ATOM   2289 H HZ3  . LYS A 1 156 ? -31.533 26.077 0.200   1.00 63.50  ? 156 LYS A HZ3  1 
ATOM   2290 N N    . LEU A 1 157 ? -38.226 22.389 -0.081  1.00 34.50  ? 157 LEU A N    1 
ATOM   2291 C CA   . LEU A 1 157 ? -39.470 22.826 -0.659  1.00 38.74  ? 157 LEU A CA   1 
ATOM   2292 C C    . LEU A 1 157 ? -39.350 24.252 -1.157  1.00 33.23  ? 157 LEU A C    1 
ATOM   2293 O O    . LEU A 1 157 ? -38.576 25.034 -0.612  1.00 30.18  ? 157 LEU A O    1 
ATOM   2294 C CB   . LEU A 1 157 ? -40.553 22.750 0.389   1.00 43.16  ? 157 LEU A CB   1 
ATOM   2295 C CG   . LEU A 1 157 ? -40.804 21.360 0.931   1.00 42.76  ? 157 LEU A CG   1 
ATOM   2296 C CD1  . LEU A 1 157 ? -41.482 21.423 2.261   1.00 43.80  ? 157 LEU A CD1  1 
ATOM   2297 C CD2  . LEU A 1 157 ? -41.642 20.688 -0.172  1.00 45.34  ? 157 LEU A CD2  1 
ATOM   2298 H H    . LEU A 1 157 ? -38.174 22.429 0.776   1.00 41.45  ? 157 LEU A H    1 
ATOM   2299 H HA   . LEU A 1 157 ? -39.714 22.264 -1.411  1.00 46.54  ? 157 LEU A HA   1 
ATOM   2300 H HB2  . LEU A 1 157 ? -40.299 23.315 1.135   1.00 51.84  ? 157 LEU A HB2  1 
ATOM   2301 H HB3  . LEU A 1 157 ? -41.382 23.068 -0.001  1.00 51.84  ? 157 LEU A HB3  1 
ATOM   2302 H HG   . LEU A 1 157 ? -40.003 20.845 1.113   1.00 51.37  ? 157 LEU A HG   1 
ATOM   2303 H HD11 . LEU A 1 157 ? -40.892 21.858 2.896   1.00 52.61  ? 157 LEU A HD11 1 
ATOM   2304 H HD12 . LEU A 1 157 ? -41.680 20.521 2.558   1.00 52.61  ? 157 LEU A HD12 1 
ATOM   2305 H HD13 . LEU A 1 157 ? -42.304 21.930 2.173   1.00 52.61  ? 157 LEU A HD13 1 
ATOM   2306 H HD21 . LEU A 1 157 ? -41.045 20.327 -0.846  1.00 54.46  ? 157 LEU A HD21 1 
ATOM   2307 H HD22 . LEU A 1 157 ? -42.229 21.350 -0.569  1.00 54.46  ? 157 LEU A HD22 1 
ATOM   2308 H HD23 . LEU A 1 157 ? -42.167 19.974 0.222   1.00 54.46  ? 157 LEU A HD23 1 
ATOM   2309 N N    . PRO A 1 158 ? -40.143 24.666 -2.147  1.00 33.02  ? 158 PRO A N    1 
ATOM   2310 C CA   . PRO A 1 158 ? -40.028 26.047 -2.656  1.00 35.71  ? 158 PRO A CA   1 
ATOM   2311 C C    . PRO A 1 158 ? -40.979 27.046 -2.002  1.00 38.88  ? 158 PRO A C    1 
ATOM   2312 O O    . PRO A 1 158 ? -40.804 28.269 -2.109  1.00 32.52  ? 158 PRO A O    1 
ATOM   2313 C CB   . PRO A 1 158 ? -40.376 25.885 -4.142  1.00 36.15  ? 158 PRO A CB   1 
ATOM   2314 C CG   . PRO A 1 158 ? -41.457 24.799 -4.142  1.00 32.42  ? 158 PRO A CG   1 
ATOM   2315 C CD   . PRO A 1 158 ? -41.127 23.887 -2.906  1.00 32.19  ? 158 PRO A CD   1 
ATOM   2316 H HA   . PRO A 1 158 ? -39.117 26.354 -2.533  1.00 42.90  ? 158 PRO A HA   1 
ATOM   2317 H HB2  . PRO A 1 158 ? -40.715 26.720 -4.500  1.00 43.43  ? 158 PRO A HB2  1 
ATOM   2318 H HB3  . PRO A 1 158 ? -39.594 25.603 -4.641  1.00 43.43  ? 158 PRO A HB3  1 
ATOM   2319 H HG2  . PRO A 1 158 ? -42.332 25.206 -4.048  1.00 38.95  ? 158 PRO A HG2  1 
ATOM   2320 H HG3  . PRO A 1 158 ? -41.414 24.292 -4.967  1.00 38.95  ? 158 PRO A HG3  1 
ATOM   2321 H HD2  . PRO A 1 158 ? -41.923 23.729 -2.374  1.00 38.67  ? 158 PRO A HD2  1 
ATOM   2322 H HD3  . PRO A 1 158 ? -40.748 23.043 -3.194  1.00 38.67  ? 158 PRO A HD3  1 
ATOM   2323 N N    . THR A 1 159 ? -42.028 26.540 -1.363  1.00 37.33  ? 159 THR A N    1 
ATOM   2324 C CA   . THR A 1 159 ? -43.026 27.402 -0.780  1.00 33.87  ? 159 THR A CA   1 
ATOM   2325 C C    . THR A 1 159 ? -43.598 26.716 0.438   1.00 34.80  ? 159 THR A C    1 
ATOM   2326 O O    . THR A 1 159 ? -43.503 25.499 0.571   1.00 32.36  ? 159 THR A O    1 
ATOM   2327 C CB   . THR A 1 159 ? -44.134 27.685 -1.781  1.00 31.82  ? 159 THR A CB   1 
ATOM   2328 O OG1  . THR A 1 159 ? -45.014 28.643 -1.211  1.00 32.66  ? 159 THR A OG1  1 
ATOM   2329 C CG2  . THR A 1 159 ? -44.938 26.409 -2.090  1.00 32.66  ? 159 THR A CG2  1 
ATOM   2330 H H    . THR A 1 159 ? -42.178 25.700 -1.258  1.00 44.85  ? 159 THR A H    1 
ATOM   2331 H HA   . THR A 1 159 ? -42.623 28.240 -0.504  1.00 40.70  ? 159 THR A HA   1 
ATOM   2332 H HB   . THR A 1 159 ? -43.752 28.013 -2.610  1.00 38.23  ? 159 THR A HB   1 
ATOM   2333 H HG1  . THR A 1 159 ? -44.572 29.244 -0.825  1.00 39.24  ? 159 THR A HG1  1 
ATOM   2334 H HG21 . THR A 1 159 ? -45.362 26.486 -2.959  1.00 39.25  ? 159 THR A HG21 1 
ATOM   2335 H HG22 . THR A 1 159 ? -45.623 26.276 -1.416  1.00 39.25  ? 159 THR A HG22 1 
ATOM   2336 H HG23 . THR A 1 159 ? -44.348 25.638 -2.095  1.00 39.25  ? 159 THR A HG23 1 
ATOM   2337 N N    . LEU A 1 160 ? -44.192 27.510 1.339   1.00 37.60  ? 160 LEU A N    1 
ATOM   2338 C CA   . LEU A 1 160 ? -45.064 27.010 2.408   1.00 40.77  ? 160 LEU A CA   1 
ATOM   2339 C C    . LEU A 1 160 ? -46.495 27.498 2.242   1.00 34.84  ? 160 LEU A C    1 
ATOM   2340 O O    . LEU A 1 160 ? -47.304 27.449 3.180   1.00 39.32  ? 160 LEU A O    1 
ATOM   2341 C CB   . LEU A 1 160 ? -44.526 27.449 3.759   1.00 30.73  ? 160 LEU A CB   1 
ATOM   2342 C CG   . LEU A 1 160 ? -43.096 27.040 4.048   1.00 35.67  ? 160 LEU A CG   1 
ATOM   2343 C CD1  . LEU A 1 160 ? -42.621 27.832 5.202   1.00 31.73  ? 160 LEU A CD1  1 
ATOM   2344 C CD2  . LEU A 1 160 ? -42.959 25.510 4.328   1.00 32.80  ? 160 LEU A CD2  1 
ATOM   2345 H H    . LEU A 1 160 ? -44.102 28.365 1.351   1.00 45.17  ? 160 LEU A H    1 
ATOM   2346 H HA   . LEU A 1 160 ? -45.070 26.041 2.379   1.00 48.97  ? 160 LEU A HA   1 
ATOM   2347 H HB2  . LEU A 1 160 ? -44.566 28.417 3.804   1.00 36.92  ? 160 LEU A HB2  1 
ATOM   2348 H HB3  . LEU A 1 160 ? -45.084 27.062 4.451   1.00 36.92  ? 160 LEU A HB3  1 
ATOM   2349 H HG   . LEU A 1 160 ? -42.544 27.214 3.269   1.00 42.85  ? 160 LEU A HG   1 
ATOM   2350 H HD11 . LEU A 1 160 ? -41.824 27.414 5.565   1.00 38.13  ? 160 LEU A HD11 1 
ATOM   2351 H HD12 . LEU A 1 160 ? -42.417 28.732 4.905   1.00 38.13  ? 160 LEU A HD12 1 
ATOM   2352 H HD13 . LEU A 1 160 ? -43.317 27.856 5.877   1.00 38.13  ? 160 LEU A HD13 1 
ATOM   2353 H HD21 . LEU A 1 160 ? -43.262 25.018 3.549   1.00 39.41  ? 160 LEU A HD21 1 
ATOM   2354 H HD22 . LEU A 1 160 ? -43.503 25.279 5.097   1.00 39.41  ? 160 LEU A HD22 1 
ATOM   2355 H HD23 . LEU A 1 160 ? -42.028 25.303 4.508   1.00 39.41  ? 160 LEU A HD23 1 
ATOM   2356 N N    . PHE A 1 161 ? -46.822 27.963 1.059   1.00 31.10  ? 161 PHE A N    1 
ATOM   2357 C CA   . PHE A 1 161 ? -48.094 28.599 0.768   1.00 35.64  ? 161 PHE A CA   1 
ATOM   2358 C C    . PHE A 1 161 ? -48.978 27.627 -0.010  1.00 37.55  ? 161 PHE A C    1 
ATOM   2359 O O    . PHE A 1 161 ? -48.519 26.970 -0.955  1.00 32.82  ? 161 PHE A O    1 
ATOM   2360 C CB   . PHE A 1 161 ? -47.853 29.894 -0.018  1.00 33.12  ? 161 PHE A CB   1 
ATOM   2361 C CG   . PHE A 1 161 ? -49.104 30.678 -0.224  1.00 40.01  ? 161 PHE A CG   1 
ATOM   2362 C CD1  . PHE A 1 161 ? -49.680 31.364 0.829   1.00 35.58  ? 161 PHE A CD1  1 
ATOM   2363 C CD2  . PHE A 1 161 ? -49.729 30.726 -1.450  1.00 40.43  ? 161 PHE A CD2  1 
ATOM   2364 C CE1  . PHE A 1 161 ? -50.875 32.073 0.663   1.00 37.32  ? 161 PHE A CE1  1 
ATOM   2365 C CE2  . PHE A 1 161 ? -50.943 31.466 -1.623  1.00 42.85  ? 161 PHE A CE2  1 
ATOM   2366 C CZ   . PHE A 1 161 ? -51.512 32.117 -0.566  1.00 37.75  ? 161 PHE A CZ   1 
ATOM   2367 H H    . PHE A 1 161 ? -46.303 27.922 0.375   1.00 37.38  ? 161 PHE A H    1 
ATOM   2368 H HA   . PHE A 1 161 ? -48.569 28.827 1.582   1.00 42.82  ? 161 PHE A HA   1 
ATOM   2369 H HB2  . PHE A 1 161 ? -47.226 30.449 0.471   1.00 39.79  ? 161 PHE A HB2  1 
ATOM   2370 H HB3  . PHE A 1 161 ? -47.490 29.672 -0.890  1.00 39.79  ? 161 PHE A HB3  1 
ATOM   2371 H HD1  . PHE A 1 161 ? -49.267 31.353 1.662   1.00 42.74  ? 161 PHE A HD1  1 
ATOM   2372 H HD2  . PHE A 1 161 ? -49.360 30.272 -2.173  1.00 48.57  ? 161 PHE A HD2  1 
ATOM   2373 H HE1  . PHE A 1 161 ? -51.247 32.520 1.389   1.00 44.83  ? 161 PHE A HE1  1 
ATOM   2374 H HE2  . PHE A 1 161 ? -51.346 31.503 -2.460  1.00 51.47  ? 161 PHE A HE2  1 
ATOM   2375 H HZ   . PHE A 1 161 ? -52.312 32.581 -0.669  1.00 45.35  ? 161 PHE A HZ   1 
ATOM   2376 N N    . GLY A 1 162 ? -50.246 27.542 0.379   1.00 34.43  ? 162 GLY A N    1 
ATOM   2377 C CA   . GLY A 1 162 ? -51.224 26.835 -0.413  1.00 36.51  ? 162 GLY A CA   1 
ATOM   2378 C C    . GLY A 1 162 ? -51.555 25.474 0.175   1.00 33.94  ? 162 GLY A C    1 
ATOM   2379 O O    . GLY A 1 162 ? -50.990 25.039 1.176   1.00 36.92  ? 162 GLY A O    1 
ATOM   2380 H H    . GLY A 1 162 ? -50.557 27.888 1.102   1.00 41.37  ? 162 GLY A H    1 
ATOM   2381 H HA2  . GLY A 1 162 ? -52.040 27.357 -0.460  1.00 43.86  ? 162 GLY A HA2  1 
ATOM   2382 H HA3  . GLY A 1 162 ? -50.880 26.706 -1.311  1.00 43.86  ? 162 GLY A HA3  1 
ATOM   2383 N N    . ARG A 1 163 ? -52.493 24.784 -0.474  1.00 38.37  ? 163 ARG A N    1 
ATOM   2384 C CA   . ARG A 1 163 ? -52.947 23.498 0.051   1.00 44.21  ? 163 ARG A CA   1 
ATOM   2385 C C    . ARG A 1 163 ? -52.015 22.346 -0.324  1.00 33.72  ? 163 ARG A C    1 
ATOM   2386 O O    . ARG A 1 163 ? -51.809 21.427 0.472   1.00 39.60  ? 163 ARG A O    1 
ATOM   2387 C CB   . ARG A 1 163 ? -54.349 23.194 -0.453  1.00 39.80  ? 163 ARG A CB   1 
ATOM   2388 C CG   . ARG A 1 163 ? -54.711 21.760 -0.120  1.00 44.76  ? 163 ARG A CG   1 
ATOM   2389 C CD   . ARG A 1 163 ? -56.130 21.363 -0.608  1.00 45.92  ? 163 ARG A CD   1 
ATOM   2390 N NE   . ARG A 1 163 ? -56.449 19.999 -0.163  1.00 48.78  ? 163 ARG A NE   1 
ATOM   2391 C CZ   . ARG A 1 163 ? -57.601 19.356 -0.389  1.00 61.22  ? 163 ARG A CZ   1 
ATOM   2392 N NH1  . ARG A 1 163 ? -58.595 19.935 -1.056  1.00 57.38  ? 163 ARG A NH1  1 
ATOM   2393 N NH2  . ARG A 1 163 ? -57.759 18.112 0.056   1.00 63.25  ? 163 ARG A NH2  1 
ATOM   2394 H H    . ARG A 1 163 ? -52.874 25.032 -1.204  1.00 46.09  ? 163 ARG A H    1 
ATOM   2395 H HA   . ARG A 1 163 ? -52.964 23.566 1.019   1.00 53.11  ? 163 ARG A HA   1 
ATOM   2396 H HB2  . ARG A 1 163 ? -54.987 23.786 -0.024  1.00 47.81  ? 163 ARG A HB2  1 
ATOM   2397 H HB3  . ARG A 1 163 ? -54.384 23.311 -1.416  1.00 47.81  ? 163 ARG A HB3  1 
ATOM   2398 H HG2  . ARG A 1 163 ? -54.072 21.167 -0.545  1.00 53.76  ? 163 ARG A HG2  1 
ATOM   2399 H HG3  . ARG A 1 163 ? -54.683 21.643 0.842   1.00 53.76  ? 163 ARG A HG3  1 
ATOM   2400 H HD2  . ARG A 1 163 ? -56.786 21.973 -0.238  1.00 55.15  ? 163 ARG A HD2  1 
ATOM   2401 H HD3  . ARG A 1 163 ? -56.161 21.390 -1.577  1.00 55.15  ? 163 ARG A HD3  1 
ATOM   2402 H HE   . ARG A 1 163 ? -55.844 19.578 0.281   1.00 58.59  ? 163 ARG A HE   1 
ATOM   2403 H HH11 . ARG A 1 163 ? -58.505 20.737 -1.351  1.00 68.91  ? 163 ARG A HH11 1 
ATOM   2404 H HH12 . ARG A 1 163 ? -59.329 19.506 -1.192  1.00 68.91  ? 163 ARG A HH12 1 
ATOM   2405 H HH21 . ARG A 1 163 ? -57.123 17.725 0.486   1.00 75.96  ? 163 ARG A HH21 1 
ATOM   2406 H HH22 . ARG A 1 163 ? -58.498 17.695 -0.087  1.00 75.96  ? 163 ARG A HH22 1 
ATOM   2407 N N    . GLY A 1 164 ? -51.471 22.372 -1.534  1.00 34.89  ? 164 GLY A N    1 
ATOM   2408 C CA   . GLY A 1 164 ? -50.615 21.276 -2.007  1.00 39.77  ? 164 GLY A CA   1 
ATOM   2409 C C    . GLY A 1 164 ? -49.403 20.960 -1.141  1.00 37.82  ? 164 GLY A C    1 
ATOM   2410 O O    . GLY A 1 164 ? -49.023 19.785 -0.985  1.00 38.16  ? 164 GLY A O    1 
ATOM   2411 H H    . GLY A 1 164 ? -51.577 23.007 -2.104  1.00 41.92  ? 164 GLY A H    1 
ATOM   2412 H HA2  . GLY A 1 164 ? -51.151 20.470 -2.063  1.00 47.78  ? 164 GLY A HA2  1 
ATOM   2413 H HA3  . GLY A 1 164 ? -50.289 21.502 -2.893  1.00 47.78  ? 164 GLY A HA3  1 
ATOM   2414 N N    . VAL A 1 165 ? -48.766 21.968 -0.561  1.00 35.71  ? 165 VAL A N    1 
ATOM   2415 C CA   . VAL A 1 165 ? -47.580 21.673 0.230   1.00 38.39  ? 165 VAL A CA   1 
ATOM   2416 C C    . VAL A 1 165 ? -47.963 20.974 1.517   1.00 40.63  ? 165 VAL A C    1 
ATOM   2417 O O    . VAL A 1 165 ? -47.180 20.173 2.060   1.00 32.04  ? 165 VAL A O    1 
ATOM   2418 C CB   . VAL A 1 165 ? -46.746 22.935 0.519   1.00 41.52  ? 165 VAL A CB   1 
ATOM   2419 C CG1  . VAL A 1 165 ? -47.501 23.990 1.387   1.00 37.73  ? 165 VAL A CG1  1 
ATOM   2420 C CG2  . VAL A 1 165 ? -45.430 22.524 1.181   1.00 38.70  ? 165 VAL A CG2  1 
ATOM   2421 H H    . VAL A 1 165 ? -48.989 22.797 -0.608  1.00 42.90  ? 165 VAL A H    1 
ATOM   2422 H HA   . VAL A 1 165 ? -47.025 21.081 -0.302  1.00 46.12  ? 165 VAL A HA   1 
ATOM   2423 H HB   . VAL A 1 165 ? -46.568 23.376 -0.326  1.00 49.87  ? 165 VAL A HB   1 
ATOM   2424 H HG11 . VAL A 1 165 ? -47.158 23.956 2.294   1.00 45.33  ? 165 VAL A HG11 1 
ATOM   2425 H HG12 . VAL A 1 165 ? -48.449 23.782 1.384   1.00 45.33  ? 165 VAL A HG12 1 
ATOM   2426 H HG13 . VAL A 1 165 ? -47.354 24.871 1.011   1.00 45.33  ? 165 VAL A HG13 1 
ATOM   2427 H HG21 . VAL A 1 165 ? -45.024 21.813 0.662   1.00 46.49  ? 165 VAL A HG21 1 
ATOM   2428 H HG22 . VAL A 1 165 ? -44.838 23.292 1.210   1.00 46.49  ? 165 VAL A HG22 1 
ATOM   2429 H HG23 . VAL A 1 165 ? -45.613 22.213 2.082   1.00 46.49  ? 165 VAL A HG23 1 
ATOM   2430 N N    . ILE A 1 166 ? -49.149 21.274 2.047   1.00 37.99  ? 166 ILE A N    1 
ATOM   2431 C CA   . ILE A 1 166 ? -49.594 20.602 3.268   1.00 35.10  ? 166 ILE A CA   1 
ATOM   2432 C C    . ILE A 1 166 ? -50.010 19.154 2.969   1.00 38.48  ? 166 ILE A C    1 
ATOM   2433 O O    . ILE A 1 166 ? -49.655 18.224 3.712   1.00 31.20  ? 166 ILE A O    1 
ATOM   2434 C CB   . ILE A 1 166 ? -50.746 21.402 3.919   1.00 39.61  ? 166 ILE A CB   1 
ATOM   2435 C CG1  . ILE A 1 166 ? -50.250 22.751 4.486   1.00 36.02  ? 166 ILE A CG1  1 
ATOM   2436 C CG2  . ILE A 1 166 ? -51.416 20.594 5.032   1.00 39.79  ? 166 ILE A CG2  1 
ATOM   2437 C CD1  . ILE A 1 166 ? -51.302 23.575 5.227   1.00 39.97  ? 166 ILE A CD1  1 
ATOM   2438 H H    . ILE A 1 166 ? -49.703 21.849 1.727   1.00 45.64  ? 166 ILE A H    1 
ATOM   2439 H HA   . ILE A 1 166 ? -48.853 20.569 3.893   1.00 42.18  ? 166 ILE A HA   1 
ATOM   2440 H HB   . ILE A 1 166 ? -51.394 21.580 3.220   1.00 47.58  ? 166 ILE A HB   1 
ATOM   2441 H HG12 . ILE A 1 166 ? -49.528 22.574 5.110   1.00 43.28  ? 166 ILE A HG12 1 
ATOM   2442 H HG13 . ILE A 1 166 ? -49.925 23.292 3.749   1.00 43.28  ? 166 ILE A HG13 1 
ATOM   2443 H HG21 . ILE A 1 166 ? -51.781 19.779 4.654   1.00 47.80  ? 166 ILE A HG21 1 
ATOM   2444 H HG22 . ILE A 1 166 ? -52.127 21.125 5.423   1.00 47.80  ? 166 ILE A HG22 1 
ATOM   2445 H HG23 . ILE A 1 166 ? -50.754 20.378 5.708   1.00 47.80  ? 166 ILE A HG23 1 
ATOM   2446 H HD11 . ILE A 1 166 ? -52.067 23.706 4.645   1.00 48.02  ? 166 ILE A HD11 1 
ATOM   2447 H HD12 . ILE A 1 166 ? -50.919 24.432 5.469   1.00 48.02  ? 166 ILE A HD12 1 
ATOM   2448 H HD13 . ILE A 1 166 ? -51.573 23.096 6.026   1.00 48.02  ? 166 ILE A HD13 1 
ATOM   2449 N N    . ASP A 1 167 ? -50.784 18.941 1.885   1.00 30.32  ? 167 ASP A N    1 
ATOM   2450 C CA   . ASP A 1 167 ? -51.165 17.581 1.524   1.00 35.87  ? 167 ASP A CA   1 
ATOM   2451 C C    . ASP A 1 167 ? -49.929 16.740 1.248   1.00 45.08  ? 167 ASP A C    1 
ATOM   2452 O O    . ASP A 1 167 ? -49.910 15.543 1.562   1.00 37.22  ? 167 ASP A O    1 
ATOM   2453 C CB   . ASP A 1 167 ? -52.063 17.539 0.288   1.00 35.43  ? 167 ASP A CB   1 
ATOM   2454 C CG   . ASP A 1 167 ? -53.489 18.030 0.561   1.00 41.90  ? 167 ASP A CG   1 
ATOM   2455 O OD1  . ASP A 1 167 ? -53.804 18.293 1.752   1.00 39.70  ? 167 ASP A OD1  1 
ATOM   2456 O OD2  . ASP A 1 167 ? -54.277 18.164 -0.416  1.00 40.32  ? 167 ASP A OD2  1 
ATOM   2457 H H    . ASP A 1 167 ? -51.088 19.555 1.365   1.00 36.43  ? 167 ASP A H    1 
ATOM   2458 H HA   . ASP A 1 167 ? -51.674 17.217 2.265   1.00 43.10  ? 167 ASP A HA   1 
ATOM   2459 H HB2  . ASP A 1 167 ? -51.678 18.106 -0.399  1.00 42.57  ? 167 ASP A HB2  1 
ATOM   2460 H HB3  . ASP A 1 167 ? -52.118 16.624 -0.029  1.00 42.57  ? 167 ASP A HB3  1 
ATOM   2461 N N    . THR A 1 168 ? -48.883 17.354 0.667   1.00 36.10  ? 168 THR A N    1 
ATOM   2462 C CA   . THR A 1 168 ? -47.648 16.626 0.380   1.00 38.44  ? 168 THR A CA   1 
ATOM   2463 C C    . THR A 1 168 ? -46.931 16.227 1.658   1.00 36.01  ? 168 THR A C    1 
ATOM   2464 O O    . THR A 1 168 ? -46.427 15.103 1.769   1.00 36.94  ? 168 THR A O    1 
ATOM   2465 C CB   . THR A 1 168 ? -46.729 17.483 -0.502  1.00 35.11  ? 168 THR A CB   1 
ATOM   2466 O OG1  . THR A 1 168 ? -47.350 17.702 -1.784  1.00 34.51  ? 168 THR A OG1  1 
ATOM   2467 C CG2  . THR A 1 168 ? -45.414 16.783 -0.727  1.00 38.28  ? 168 THR A CG2  1 
ATOM   2468 H H    . THR A 1 168 ? -48.868 18.182 0.433   1.00 43.37  ? 168 THR A H    1 
ATOM   2469 H HA   . THR A 1 168 ? -47.870 15.816 -0.105  1.00 46.17  ? 168 THR A HA   1 
ATOM   2470 H HB   . THR A 1 168 ? -46.567 18.332 -0.062  1.00 42.18  ? 168 THR A HB   1 
ATOM   2471 H HG1  . THR A 1 168 ? -48.045 18.165 -1.691  1.00 41.46  ? 168 THR A HG1  1 
ATOM   2472 H HG21 . THR A 1 168 ? -45.568 15.852 -0.948  1.00 45.98  ? 168 THR A HG21 1 
ATOM   2473 H HG22 . THR A 1 168 ? -44.872 16.831 0.076   1.00 45.98  ? 168 THR A HG22 1 
ATOM   2474 H HG23 . THR A 1 168 ? -44.934 17.206 -1.456  1.00 45.98  ? 168 THR A HG23 1 
ATOM   2475 N N    . MET A 1 169 ? -46.846 17.135 2.631   1.00 34.57  ? 169 MET A N    1 
ATOM   2476 C CA   . MET A 1 169 ? -46.242 16.738 3.888   1.00 34.26  ? 169 MET A CA   1 
ATOM   2477 C C    . MET A 1 169 ? -47.092 15.666 4.597   1.00 41.93  ? 169 MET A C    1 
ATOM   2478 O O    . MET A 1 169 ? -46.542 14.804 5.287   1.00 37.22  ? 169 MET A O    1 
ATOM   2479 C CB   . MET A 1 169 ? -46.037 17.952 4.800   1.00 38.52  ? 169 MET A CB   1 
ATOM   2480 C CG   . MET A 1 169 ? -44.964 18.913 4.345   1.00 41.57  ? 169 MET A CG   1 
ATOM   2481 S SD   . MET A 1 169 ? -43.296 18.228 4.206   1.00 39.44  ? 169 MET A SD   1 
ATOM   2482 C CE   . MET A 1 169 ? -43.341 17.960 2.454   1.00 37.11  ? 169 MET A CE   1 
ATOM   2483 H H    . MET A 1 169 ? -47.121 17.949 2.585   1.00 41.54  ? 169 MET A H    1 
ATOM   2484 H HA   . MET A 1 169 ? -45.362 16.373 3.703   1.00 41.16  ? 169 MET A HA   1 
ATOM   2485 H HB2  . MET A 1 169 ? -46.871 18.446 4.846   1.00 46.27  ? 169 MET A HB2  1 
ATOM   2486 H HB3  . MET A 1 169 ? -45.791 17.636 5.683   1.00 46.27  ? 169 MET A HB3  1 
ATOM   2487 H HG2  . MET A 1 169 ? -45.209 19.249 3.469   1.00 49.93  ? 169 MET A HG2  1 
ATOM   2488 H HG3  . MET A 1 169 ? -44.921 19.644 4.982   1.00 49.93  ? 169 MET A HG3  1 
ATOM   2489 H HE1  . MET A 1 169 ? -42.508 17.547 2.176   1.00 44.58  ? 169 MET A HE1  1 
ATOM   2490 H HE2  . MET A 1 169 ? -44.086 17.376 2.243   1.00 44.58  ? 169 MET A HE2  1 
ATOM   2491 H HE3  . MET A 1 169 ? -43.453 18.813 2.007   1.00 44.58  ? 169 MET A HE3  1 
ATOM   2492 N N    . ARG A 1 170 ? -48.421 15.672 4.429   1.00 38.91  ? 170 ARG A N    1 
ATOM   2493 C CA   . ARG A 1 170 ? -49.242 14.614 5.033   1.00 45.43  ? 170 ARG A CA   1 
ATOM   2494 C C    . ARG A 1 170 ? -48.906 13.240 4.440   1.00 36.87  ? 170 ARG A C    1 
ATOM   2495 O O    . ARG A 1 170 ? -48.780 12.246 5.173   1.00 40.96  ? 170 ARG A O    1 
ATOM   2496 C CB   . ARG A 1 170 ? -50.731 14.938 4.843   1.00 41.83  ? 170 ARG A CB   1 
ATOM   2497 C CG   . ARG A 1 170 ? -51.674 13.792 5.250   1.00 41.06  ? 170 ARG A CG   1 
ATOM   2498 C CD   . ARG A 1 170 ? -51.491 13.451 6.729   1.00 40.12  ? 170 ARG A CD   1 
ATOM   2499 N NE   . ARG A 1 170 ? -52.343 12.363 7.157   1.00 53.20  ? 170 ARG A NE   1 
ATOM   2500 C CZ   . ARG A 1 170 ? -51.997 11.091 7.103   1.00 49.65  ? 170 ARG A CZ   1 
ATOM   2501 N NH1  . ARG A 1 170 ? -50.796 10.741 6.637   1.00 44.42  ? 170 ARG A NH1  1 
ATOM   2502 N NH2  . ARG A 1 170 ? -52.855 10.171 7.515   1.00 52.04  ? 170 ARG A NH2  1 
ATOM   2503 H H    . ARG A 1 170 ? -48.861 16.261 3.982   1.00 46.74  ? 170 ARG A H    1 
ATOM   2504 H HA   . ARG A 1 170 ? -49.060 14.578 5.985   1.00 54.57  ? 170 ARG A HA   1 
ATOM   2505 H HB2  . ARG A 1 170 ? -50.953 15.711 5.386   1.00 50.24  ? 170 ARG A HB2  1 
ATOM   2506 H HB3  . ARG A 1 170 ? -50.890 15.134 3.907   1.00 50.24  ? 170 ARG A HB3  1 
ATOM   2507 H HG2  . ARG A 1 170 ? -52.595 14.061 5.106   1.00 49.32  ? 170 ARG A HG2  1 
ATOM   2508 H HG3  . ARG A 1 170 ? -51.473 13.003 4.723   1.00 49.32  ? 170 ARG A HG3  1 
ATOM   2509 H HD2  . ARG A 1 170 ? -50.569 13.189 6.882   1.00 48.19  ? 170 ARG A HD2  1 
ATOM   2510 H HD3  . ARG A 1 170 ? -51.708 14.231 7.263   1.00 48.19  ? 170 ARG A HD3  1 
ATOM   2511 H HE   . ARG A 1 170 ? -53.123 12.557 7.464   1.00 63.89  ? 170 ARG A HE   1 
ATOM   2512 H HH11 . ARG A 1 170 ? -50.245 11.346 6.371   1.00 53.35  ? 170 ARG A HH11 1 
ATOM   2513 H HH12 . ARG A 1 170 ? -50.572 9.911  6.604   1.00 53.35  ? 170 ARG A HH12 1 
ATOM   2514 H HH21 . ARG A 1 170 ? -52.640 9.339  7.485   1.00 62.50  ? 170 ARG A HH21 1 
ATOM   2515 H HH22 . ARG A 1 170 ? -53.627 10.406 7.813   1.00 62.50  ? 170 ARG A HH22 1 
ATOM   2516 N N    . ILE A 1 171 ? -48.729 13.160 3.120   1.00 37.20  ? 171 ILE A N    1 
ATOM   2517 C CA   . ILE A 1 171 ? -48.298 11.902 2.514   1.00 41.95  ? 171 ILE A CA   1 
ATOM   2518 C C    . ILE A 1 171 ? -46.938 11.474 3.055   1.00 42.18  ? 171 ILE A C    1 
ATOM   2519 O O    . ILE A 1 171 ? -46.775 10.349 3.535   1.00 43.41  ? 171 ILE A O    1 
ATOM   2520 C CB   . ILE A 1 171 ? -48.318 12.021 0.982   1.00 43.51  ? 171 ILE A CB   1 
ATOM   2521 C CG1  . ILE A 1 171 ? -49.785 12.197 0.587   1.00 41.20  ? 171 ILE A CG1  1 
ATOM   2522 C CG2  . ILE A 1 171 ? -47.682 10.792 0.353   1.00 47.71  ? 171 ILE A CG2  1 
ATOM   2523 C CD1  . ILE A 1 171 ? -50.044 12.471 -0.849  1.00 50.78  ? 171 ILE A CD1  1 
ATOM   2524 H H    . ILE A 1 171 ? -48.850 13.806 2.565   1.00 44.69  ? 171 ILE A H    1 
ATOM   2525 H HA   . ILE A 1 171 ? -48.924 11.205 2.762   1.00 50.39  ? 171 ILE A HA   1 
ATOM   2526 H HB   . ILE A 1 171 ? -47.800 12.778 0.667   1.00 52.27  ? 171 ILE A HB   1 
ATOM   2527 H HG12 . ILE A 1 171 ? -50.259 11.382 0.814   1.00 49.49  ? 171 ILE A HG12 1 
ATOM   2528 H HG13 . ILE A 1 171 ? -50.147 12.943 1.091   1.00 49.49  ? 171 ILE A HG13 1 
ATOM   2529 H HG21 . ILE A 1 171 ? -48.073 9.997  0.748   1.00 57.30  ? 171 ILE A HG21 1 
ATOM   2530 H HG22 . ILE A 1 171 ? -46.727 10.809 0.520   1.00 57.30  ? 171 ILE A HG22 1 
ATOM   2531 H HG23 . ILE A 1 171 ? -47.851 10.803 -0.603  1.00 57.30  ? 171 ILE A HG23 1 
ATOM   2532 H HD11 . ILE A 1 171 ? -50.999 12.574 -0.983  1.00 60.99  ? 171 ILE A HD11 1 
ATOM   2533 H HD12 . ILE A 1 171 ? -49.584 13.286 -1.103  1.00 60.99  ? 171 ILE A HD12 1 
ATOM   2534 H HD13 . ILE A 1 171 ? -49.714 11.727 -1.377  1.00 60.99  ? 171 ILE A HD13 1 
ATOM   2535 N N    . TYR A 1 172 ? -45.933 12.355 3.015   1.00 38.84  ? 172 TYR A N    1 
ATOM   2536 C CA   . TYR A 1 172 ? -44.620 11.945 3.517   1.00 43.48  ? 172 TYR A CA   1 
ATOM   2537 C C    . TYR A 1 172 ? -44.708 11.417 4.950   1.00 44.69  ? 172 TYR A C    1 
ATOM   2538 O O    . TYR A 1 172 ? -43.957 10.499 5.333   1.00 34.19  ? 172 TYR A O    1 
ATOM   2539 C CB   . TYR A 1 172 ? -43.611 13.094 3.427   1.00 39.13  ? 172 TYR A CB   1 
ATOM   2540 C CG   . TYR A 1 172 ? -42.944 13.098 2.065   1.00 44.93  ? 172 TYR A CG   1 
ATOM   2541 C CD1  . TYR A 1 172 ? -41.866 12.262 1.817   1.00 44.64  ? 172 TYR A CD1  1 
ATOM   2542 C CD2  . TYR A 1 172 ? -43.434 13.882 1.013   1.00 41.35  ? 172 TYR A CD2  1 
ATOM   2543 C CE1  . TYR A 1 172 ? -41.255 12.218 0.572   1.00 45.79  ? 172 TYR A CE1  1 
ATOM   2544 C CE2  . TYR A 1 172 ? -42.820 13.854 -0.261  1.00 41.09  ? 172 TYR A CE2  1 
ATOM   2545 C CZ   . TYR A 1 172 ? -41.730 12.996 -0.457  1.00 47.26  ? 172 TYR A CZ   1 
ATOM   2546 O OH   . TYR A 1 172 ? -41.094 12.909 -1.667  1.00 44.66  ? 172 TYR A OH   1 
ATOM   2547 H H    . TYR A 1 172 ? -45.983 13.160 2.715   1.00 46.65  ? 172 TYR A H    1 
ATOM   2548 H HA   . TYR A 1 172 ? -44.286 11.232 2.951   1.00 52.23  ? 172 TYR A HA   1 
ATOM   2549 H HB2  . TYR A 1 172 ? -44.069 13.940 3.552   1.00 47.00  ? 172 TYR A HB2  1 
ATOM   2550 H HB3  . TYR A 1 172 ? -42.929 12.982 4.107   1.00 47.00  ? 172 TYR A HB3  1 
ATOM   2551 H HD1  . TYR A 1 172 ? -41.545 11.720 2.501   1.00 53.62  ? 172 TYR A HD1  1 
ATOM   2552 H HD2  . TYR A 1 172 ? -44.173 14.429 1.154   1.00 49.67  ? 172 TYR A HD2  1 
ATOM   2553 H HE1  . TYR A 1 172 ? -40.524 11.661 0.433   1.00 55.00  ? 172 TYR A HE1  1 
ATOM   2554 H HE2  . TYR A 1 172 ? -43.133 14.391 -0.952  1.00 49.35  ? 172 TYR A HE2  1 
ATOM   2555 H HH   . TYR A 1 172 ? -40.396 12.448 -1.593  1.00 53.65  ? 172 TYR A HH   1 
ATOM   2556 N N    . CYS A 1 173 ? -45.616 11.977 5.755   1.00 40.17  ? 173 CYS A N    1 
ATOM   2557 C CA   . CYS A 1 173 ? -45.737 11.589 7.159   1.00 43.80  ? 173 CYS A CA   1 
ATOM   2558 C C    . CYS A 1 173 ? -46.344 10.203 7.374   1.00 47.27  ? 173 CYS A C    1 
ATOM   2559 O O    . CYS A 1 173 ? -46.418 9.759  8.532   1.00 46.70  ? 173 CYS A O    1 
ATOM   2560 C CB   . CYS A 1 173 ? -46.587 12.611 7.913   1.00 44.57  ? 173 CYS A CB   1 
ATOM   2561 S SG   . CYS A 1 173 ? -45.734 14.161 8.319   1.00 44.50  ? 173 CYS A SG   1 
ATOM   2562 H H    . CYS A 1 173 ? -46.173 12.584 5.510   1.00 48.25  ? 173 CYS A H    1 
ATOM   2563 H HA   . CYS A 1 173 ? -44.841 11.580 7.532   1.00 52.61  ? 173 CYS A HA   1 
ATOM   2564 H HB2  . CYS A 1 173 ? -47.355 12.836 7.364   1.00 53.53  ? 173 CYS A HB2  1 
ATOM   2565 H HB3  . CYS A 1 173 ? -46.880 12.212 8.747   1.00 53.53  ? 173 CYS A HB3  1 
ATOM   2566 H HG   . CYS A 1 173 ? -46.430 14.810 9.050   1.00 53.45  ? 173 CYS A HG   1 
ATOM   2567 N N    . SER A 1 174 ? -46.861 9.566  6.316   1.00 42.14  ? 174 SER A N    1 
ATOM   2568 C CA   . SER A 1 174 ? -47.233 8.153  6.331   1.00 46.93  ? 174 SER A CA   1 
ATOM   2569 C C    . SER A 1 174 ? -46.125 7.262  5.761   1.00 51.48  ? 174 SER A C    1 
ATOM   2570 O O    . SER A 1 174 ? -46.121 6.052  6.017   1.00 51.56  ? 174 SER A O    1 
ATOM   2571 C CB   . SER A 1 174 ? -48.516 7.928  5.510   1.00 41.23  ? 174 SER A CB   1 
ATOM   2572 O OG   . SER A 1 174 ? -49.698 8.260  6.221   1.00 50.71  ? 174 SER A OG   1 
ATOM   2573 H H    . SER A 1 174 ? -47.010 9.945  5.558   1.00 50.62  ? 174 SER A H    1 
ATOM   2574 H HA   . SER A 1 174 ? -47.418 7.880  7.243   1.00 56.37  ? 174 SER A HA   1 
ATOM   2575 H HB2  . SER A 1 174 ? -48.471 8.481  4.714   1.00 49.53  ? 174 SER A HB2  1 
ATOM   2576 H HB3  . SER A 1 174 ? -48.561 6.991  5.262   1.00 49.53  ? 174 SER A HB3  1 
ATOM   2577 H HG   . SER A 1 174 ? -49.684 7.908  6.983   1.00 60.90  ? 174 SER A HG   1 
ATOM   2578 N N    . LEU A 1 175 ? -45.211 7.842  4.976   1.00 45.95  ? 175 LEU A N    1 
ATOM   2579 C CA   . LEU A 1 175 ? -44.131 7.137  4.306   1.00 45.84  ? 175 LEU A CA   1 
ATOM   2580 C C    . LEU A 1 175 ? -42.901 7.003  5.180   1.00 46.49  ? 175 LEU A C    1 
ATOM   2581 O O    . LEU A 1 175 ? -42.137 6.034  5.034   1.00 49.36  ? 175 LEU A O    1 
ATOM   2582 C CB   . LEU A 1 175 ? -43.775 7.866  3.008   1.00 38.14  ? 175 LEU A CB   1 
ATOM   2583 C CG   . LEU A 1 175 ? -44.984 7.903  2.073   1.00 46.81  ? 175 LEU A CG   1 
ATOM   2584 C CD1  . LEU A 1 175 ? -44.653 8.703  0.813   1.00 48.25  ? 175 LEU A CD1  1 
ATOM   2585 C CD2  . LEU A 1 175 ? -45.439 6.548  1.670   1.00 50.28  ? 175 LEU A CD2  1 
ATOM   2586 H H    . LEU A 1 175 ? -45.199 8.686  4.812   1.00 55.19  ? 175 LEU A H    1 
ATOM   2587 H HA   . LEU A 1 175 ? -44.421 6.241  4.074   1.00 55.06  ? 175 LEU A HA   1 
ATOM   2588 H HB2  . LEU A 1 175 ? -43.509 8.777  3.210   1.00 45.82  ? 175 LEU A HB2  1 
ATOM   2589 H HB3  . LEU A 1 175 ? -43.050 7.400  2.562   1.00 45.82  ? 175 LEU A HB3  1 
ATOM   2590 H HG   . LEU A 1 175 ? -45.709 8.326  2.560   1.00 56.22  ? 175 LEU A HG   1 
ATOM   2591 H HD11 . LEU A 1 175 ? -44.456 9.619  1.064   1.00 57.96  ? 175 LEU A HD11 1 
ATOM   2592 H HD12 . LEU A 1 175 ? -43.881 8.305  0.381   1.00 57.96  ? 175 LEU A HD12 1 
ATOM   2593 H HD13 . LEU A 1 175 ? -45.415 8.680  0.215   1.00 57.96  ? 175 LEU A HD13 1 
ATOM   2594 H HD21 . LEU A 1 175 ? -45.986 6.175  2.379   1.00 60.39  ? 175 LEU A HD21 1 
ATOM   2595 H HD22 . LEU A 1 175 ? -44.662 5.986  1.521   1.00 60.39  ? 175 LEU A HD22 1 
ATOM   2596 H HD23 . LEU A 1 175 ? -45.958 6.619  0.854   1.00 60.39  ? 175 LEU A HD23 1 
ATOM   2597 N N    . PHE A 1 176 ? -42.695 7.953  6.077   1.00 44.28  ? 176 PHE A N    1 
ATOM   2598 C CA   . PHE A 1 176 ? -41.565 7.942  6.981   1.00 44.81  ? 176 PHE A CA   1 
ATOM   2599 C C    . PHE A 1 176 ? -42.085 8.148  8.394   1.00 52.42  ? 176 PHE A C    1 
ATOM   2600 O O    . PHE A 1 176 ? -43.132 8.777  8.606   1.00 48.04  ? 176 PHE A O    1 
ATOM   2601 C CB   . PHE A 1 176 ? -40.529 9.006  6.558   1.00 48.40  ? 176 PHE A CB   1 
ATOM   2602 C CG   . PHE A 1 176 ? -39.909 8.707  5.234   1.00 43.51  ? 176 PHE A CG   1 
ATOM   2603 C CD1  . PHE A 1 176 ? -40.608 8.989  4.067   1.00 42.89  ? 176 PHE A CD1  1 
ATOM   2604 C CD2  . PHE A 1 176 ? -38.659 8.074  5.146   1.00 48.69  ? 176 PHE A CD2  1 
ATOM   2605 C CE1  . PHE A 1 176 ? -40.071 8.675  2.812   1.00 45.23  ? 176 PHE A CE1  1 
ATOM   2606 C CE2  . PHE A 1 176 ? -38.111 7.752  3.896   1.00 46.61  ? 176 PHE A CE2  1 
ATOM   2607 C CZ   . PHE A 1 176 ? -38.828 8.049  2.722   1.00 39.77  ? 176 PHE A CZ   1 
ATOM   2608 H H    . PHE A 1 176 ? -43.212 8.632  6.182   1.00 53.18  ? 176 PHE A H    1 
ATOM   2609 H HA   . PHE A 1 176 ? -41.099 7.091  6.980   1.00 53.83  ? 176 PHE A HA   1 
ATOM   2610 H HB2  . PHE A 1 176 ? -40.968 9.868  6.497   1.00 58.13  ? 176 PHE A HB2  1 
ATOM   2611 H HB3  . PHE A 1 176 ? -39.821 9.040  7.221   1.00 58.13  ? 176 PHE A HB3  1 
ATOM   2612 H HD1  . PHE A 1 176 ? -41.445 9.393  4.120   1.00 51.51  ? 176 PHE A HD1  1 
ATOM   2613 H HD2  . PHE A 1 176 ? -38.191 7.865  5.922   1.00 58.48  ? 176 PHE A HD2  1 
ATOM   2614 H HE1  . PHE A 1 176 ? -40.543 8.883  2.038   1.00 54.33  ? 176 PHE A HE1  1 
ATOM   2615 H HE2  . PHE A 1 176 ? -37.277 7.345  3.843   1.00 55.98  ? 176 PHE A HE2  1 
ATOM   2616 H HZ   . PHE A 1 176 ? -38.474 7.829  1.890   1.00 47.77  ? 176 PHE A HZ   1 
ATOM   2617 N N    . LYS A 1 177 ? -41.351 7.582  9.355   1.00 46.96  ? 177 LYS A N    1 
ATOM   2618 C CA   . LYS A 1 177 ? -41.750 7.604  10.753  1.00 53.03  ? 177 LYS A CA   1 
ATOM   2619 C C    . LYS A 1 177 ? -41.154 8.788  11.495  1.00 50.96  ? 177 LYS A C    1 
ATOM   2620 O O    . LYS A 1 177 ? -41.604 9.087  12.607  1.00 46.71  ? 177 LYS A O    1 
ATOM   2621 C CB   . LYS A 1 177 ? -41.339 6.277  11.431  1.00 59.51  ? 177 LYS A CB   1 
ATOM   2622 C CG   . LYS A 1 177 ? -42.046 5.034  10.815  1.00 58.24  ? 177 LYS A CG   1 
ATOM   2623 C CD   . LYS A 1 177 ? -41.498 3.693  11.356  1.00 73.04  ? 177 LYS A CD   1 
ATOM   2624 C CE   . LYS A 1 177 ? -39.967 3.569  11.220  1.00 85.78  ? 177 LYS A CE   1 
ATOM   2625 N NZ   . LYS A 1 177 ? -39.505 2.146  11.272  1.00 81.74  ? 177 LYS A NZ   1 
ATOM   2626 H H    . LYS A 1 177 ? -40.608 7.173  9.215   1.00 56.40  ? 177 LYS A H    1 
ATOM   2627 H HA   . LYS A 1 177 ? -42.715 7.672  10.823  1.00 63.68  ? 177 LYS A HA   1 
ATOM   2628 H HB2  . LYS A 1 177 ? -40.382 6.156  11.332  1.00 71.46  ? 177 LYS A HB2  1 
ATOM   2629 H HB3  . LYS A 1 177 ? -41.573 6.319  12.372  1.00 71.46  ? 177 LYS A HB3  1 
ATOM   2630 H HG2  . LYS A 1 177 ? -42.992 5.075  11.023  1.00 69.94  ? 177 LYS A HG2  1 
ATOM   2631 H HG3  . LYS A 1 177 ? -41.917 5.043  9.854   1.00 69.94  ? 177 LYS A HG3  1 
ATOM   2632 H HD2  . LYS A 1 177 ? -41.721 3.617  12.297  1.00 87.70  ? 177 LYS A HD2  1 
ATOM   2633 H HD3  . LYS A 1 177 ? -41.902 2.964  10.860  1.00 87.70  ? 177 LYS A HD3  1 
ATOM   2634 H HE2  . LYS A 1 177 ? -39.692 3.944  10.369  1.00 102.98 ? 177 LYS A HE2  1 
ATOM   2635 H HE3  . LYS A 1 177 ? -39.543 4.051  11.947  1.00 102.98 ? 177 LYS A HE3  1 
ATOM   2636 H HZ1  . LYS A 1 177 ? -39.695 1.793  12.068  1.00 98.14  ? 177 LYS A HZ1  1 
ATOM   2637 H HZ2  . LYS A 1 177 ? -38.626 2.106  11.141  1.00 98.14  ? 177 LYS A HZ2  1 
ATOM   2638 H HZ3  . LYS A 1 177 ? -39.914 1.670  10.641  1.00 98.14  ? 177 LYS A HZ3  1 
ATOM   2639 N N    . ASN A 1 178 ? -40.160 9.460  10.910  1.00 48.32  ? 178 ASN A N    1 
ATOM   2640 C CA   . ASN A 1 178 ? -39.553 10.647 11.491  1.00 51.02  ? 178 ASN A CA   1 
ATOM   2641 C C    . ASN A 1 178 ? -39.483 11.695 10.394  1.00 57.51  ? 178 ASN A C    1 
ATOM   2642 O O    . ASN A 1 178 ? -38.739 11.519 9.422   1.00 44.73  ? 178 ASN A O    1 
ATOM   2643 C CB   . ASN A 1 178 ? -38.169 10.347 12.056  1.00 60.75  ? 178 ASN A CB   1 
ATOM   2644 C CG   . ASN A 1 178 ? -38.239 9.581  13.371  1.00 76.17  ? 178 ASN A CG   1 
ATOM   2645 O OD1  . ASN A 1 178 ? -38.053 8.359  13.409  1.00 83.99  ? 178 ASN A OD1  1 
ATOM   2646 N ND2  . ASN A 1 178 ? -38.540 10.300 14.456  1.00 85.93  ? 178 ASN A ND2  1 
ATOM   2647 H H    . ASN A 1 178 ? -39.814 9.237  10.154  1.00 58.03  ? 178 ASN A H    1 
ATOM   2648 H HA   . ASN A 1 178 ? -40.101 10.981 12.219  1.00 61.28  ? 178 ASN A HA   1 
ATOM   2649 H HB2  . ASN A 1 178 ? -37.674 9.809  11.418  1.00 72.95  ? 178 ASN A HB2  1 
ATOM   2650 H HB3  . ASN A 1 178 ? -37.703 11.182 12.217  1.00 72.95  ? 178 ASN A HB3  1 
ATOM   2651 H HD21 . ASN A 1 178 ? -38.680 11.146 14.387  1.00 103.17 ? 178 ASN A HD21 1 
ATOM   2652 H HD22 . ASN A 1 178 ? -38.592 9.918  15.225  1.00 103.17 ? 178 ASN A HD22 1 
ATOM   2653 N N    . VAL A 1 179 ? -40.290 12.753 10.533  1.00 51.11  ? 179 VAL A N    1 
ATOM   2654 C CA   . VAL A 1 179 ? -40.354 13.859 9.584   1.00 50.30  ? 179 VAL A CA   1 
ATOM   2655 C C    . VAL A 1 179 ? -40.171 15.176 10.334  1.00 42.60  ? 179 VAL A C    1 
ATOM   2656 O O    . VAL A 1 179 ? -40.928 15.485 11.266  1.00 39.95  ? 179 VAL A O    1 
ATOM   2657 C CB   . VAL A 1 179 ? -41.689 13.885 8.808   1.00 45.87  ? 179 VAL A CB   1 
ATOM   2658 C CG1  . VAL A 1 179 ? -41.766 15.184 7.994   1.00 47.28  ? 179 VAL A CG1  1 
ATOM   2659 C CG2  . VAL A 1 179 ? -41.876 12.678 7.908   1.00 40.78  ? 179 VAL A CG2  1 
ATOM   2660 H H    . VAL A 1 179 ? -40.829 12.852 11.196  1.00 61.39  ? 179 VAL A H    1 
ATOM   2661 H HA   . VAL A 1 179 ? -39.620 13.761 8.958   1.00 60.41  ? 179 VAL A HA   1 
ATOM   2662 H HB   . VAL A 1 179 ? -42.415 13.849 9.450   1.00 55.09  ? 179 VAL A HB   1 
ATOM   2663 H HG11 . VAL A 1 179 ? -42.411 15.071 7.279   1.00 56.79  ? 179 VAL A HG11 1 
ATOM   2664 H HG12 . VAL A 1 179 ? -42.043 15.907 8.579   1.00 56.79  ? 179 VAL A HG12 1 
ATOM   2665 H HG13 . VAL A 1 179 ? -40.891 15.376 7.623   1.00 56.79  ? 179 VAL A HG13 1 
ATOM   2666 H HG21 . VAL A 1 179 ? -41.160 12.658 7.253   1.00 48.99  ? 179 VAL A HG21 1 
ATOM   2667 H HG22 . VAL A 1 179 ? -42.733 12.748 7.459   1.00 48.99  ? 179 VAL A HG22 1 
ATOM   2668 H HG23 . VAL A 1 179 ? -41.851 11.873 8.449   1.00 48.99  ? 179 VAL A HG23 1 
ATOM   2669 N N    . ARG A 1 180 ? -39.204 15.962 9.909   1.00 47.59  ? 180 ARG A N    1 
ATOM   2670 C CA   . ARG A 1 180 ? -38.909 17.263 10.494  1.00 44.83  ? 180 ARG A CA   1 
ATOM   2671 C C    . ARG A 1 180 ? -39.046 18.296 9.386   1.00 43.44  ? 180 ARG A C    1 
ATOM   2672 O O    . ARG A 1 180 ? -38.564 18.077 8.282   1.00 39.01  ? 180 ARG A O    1 
ATOM   2673 C CB   . ARG A 1 180 ? -37.479 17.273 11.064  1.00 44.58  ? 180 ARG A CB   1 
ATOM   2674 C CG   . ARG A 1 180 ? -37.070 18.568 11.760  1.00 54.49  ? 180 ARG A CG   1 
ATOM   2675 C CD   . ARG A 1 180 ? -35.576 18.543 12.222  1.00 56.17  ? 180 ARG A CD   1 
ATOM   2676 N NE   . ARG A 1 180 ? -35.456 18.083 13.606  1.00 64.10  ? 180 ARG A NE   1 
ATOM   2677 C CZ   . ARG A 1 180 ? -34.777 18.714 14.563  1.00 61.73  ? 180 ARG A CZ   1 
ATOM   2678 N NH1  . ARG A 1 180 ? -34.126 19.849 14.299  1.00 55.01  ? 180 ARG A NH1  1 
ATOM   2679 N NH2  . ARG A 1 180 ? -34.752 18.211 15.798  1.00 56.15  ? 180 ARG A NH2  1 
ATOM   2680 H H    . ARG A 1 180 ? -38.681 15.761 9.256   1.00 57.16  ? 180 ARG A H    1 
ATOM   2681 H HA   . ARG A 1 180 ? -39.525 17.479 11.212  1.00 53.85  ? 180 ARG A HA   1 
ATOM   2682 H HB2  . ARG A 1 180 ? -37.403 16.557 11.714  1.00 53.55  ? 180 ARG A HB2  1 
ATOM   2683 H HB3  . ARG A 1 180 ? -36.857 17.126 10.334  1.00 53.55  ? 180 ARG A HB3  1 
ATOM   2684 H HG2  . ARG A 1 180 ? -37.183 19.310 11.145  1.00 65.44  ? 180 ARG A HG2  1 
ATOM   2685 H HG3  . ARG A 1 180 ? -37.626 18.698 12.544  1.00 65.44  ? 180 ARG A HG3  1 
ATOM   2686 H HD2  . ARG A 1 180 ? -35.074 17.938 11.653  1.00 67.46  ? 180 ARG A HD2  1 
ATOM   2687 H HD3  . ARG A 1 180 ? -35.206 19.437 12.163  1.00 67.46  ? 180 ARG A HD3  1 
ATOM   2688 H HE   . ARG A 1 180 ? -35.852 17.349 13.817  1.00 76.97  ? 180 ARG A HE   1 
ATOM   2689 H HH11 . ARG A 1 180 ? -34.141 20.179 13.505  1.00 66.07  ? 180 ARG A HH11 1 
ATOM   2690 H HH12 . ARG A 1 180 ? -33.690 20.250 14.923  1.00 66.07  ? 180 ARG A HH12 1 
ATOM   2691 H HH21 . ARG A 1 180 ? -35.173 17.481 15.973  1.00 67.43  ? 180 ARG A HH21 1 
ATOM   2692 H HH22 . ARG A 1 180 ? -34.316 18.615 16.419  1.00 67.43  ? 180 ARG A HH22 1 
ATOM   2693 N N    . LEU A 1 181 ? -39.721 19.397 9.655   1.00 43.42  ? 181 LEU A N    1 
ATOM   2694 C CA   . LEU A 1 181 ? -39.698 20.559 8.790   1.00 34.00  ? 181 LEU A CA   1 
ATOM   2695 C C    . LEU A 1 181 ? -38.809 21.615 9.403   1.00 42.05  ? 181 LEU A C    1 
ATOM   2696 O O    . LEU A 1 181 ? -38.989 21.965 10.565  1.00 45.49  ? 181 LEU A O    1 
ATOM   2697 C CB   . LEU A 1 181 ? -41.075 21.163 8.575   1.00 43.71  ? 181 LEU A CB   1 
ATOM   2698 C CG   . LEU A 1 181 ? -41.841 20.839 7.313   1.00 49.88  ? 181 LEU A CG   1 
ATOM   2699 C CD1  . LEU A 1 181 ? -43.117 21.714 7.341   1.00 38.53  ? 181 LEU A CD1  1 
ATOM   2700 C CD2  . LEU A 1 181 ? -40.997 21.068 6.093   1.00 38.82  ? 181 LEU A CD2  1 
ATOM   2701 H H    . LEU A 1 181 ? -40.214 19.498 10.353  1.00 52.16  ? 181 LEU A H    1 
ATOM   2702 H HA   . LEU A 1 181 ? -39.355 20.278 7.927   1.00 40.86  ? 181 LEU A HA   1 
ATOM   2703 H HB2  . LEU A 1 181 ? -41.634 20.877 9.314   1.00 52.50  ? 181 LEU A HB2  1 
ATOM   2704 H HB3  . LEU A 1 181 ? -40.972 22.128 8.591   1.00 52.50  ? 181 LEU A HB3  1 
ATOM   2705 H HG   . LEU A 1 181 ? -42.092 19.903 7.264   1.00 59.91  ? 181 LEU A HG   1 
ATOM   2706 H HD11 . LEU A 1 181 ? -43.607 21.584 6.514   1.00 46.29  ? 181 LEU A HD11 1 
ATOM   2707 H HD12 . LEU A 1 181 ? -42.860 22.645 7.430   1.00 46.29  ? 181 LEU A HD12 1 
ATOM   2708 H HD13 . LEU A 1 181 ? -43.665 21.448 8.096   1.00 46.29  ? 181 LEU A HD13 1 
ATOM   2709 H HD21 . LEU A 1 181 ? -40.516 20.252 5.884   1.00 46.63  ? 181 LEU A HD21 1 
ATOM   2710 H HD22 . LEU A 1 181 ? -41.573 21.313 5.352   1.00 46.63  ? 181 LEU A HD22 1 
ATOM   2711 H HD23 . LEU A 1 181 ? -40.369 21.785 6.274   1.00 46.63  ? 181 LEU A HD23 1 
ATOM   2712 N N    . LEU A 1 182 ? -37.900 22.173 8.612   1.00 39.52  ? 182 LEU A N    1 
ATOM   2713 C CA   . LEU A 1 182 ? -37.030 23.212 9.139   1.00 43.96  ? 182 LEU A CA   1 
ATOM   2714 C C    . LEU A 1 182 ? -36.663 24.230 8.070   1.00 33.81  ? 182 LEU A C    1 
ATOM   2715 O O    . LEU A 1 182 ? -36.812 24.004 6.867   1.00 36.17  ? 182 LEU A O    1 
ATOM   2716 C CB   . LEU A 1 182 ? -35.761 22.579 9.699   1.00 43.82  ? 182 LEU A CB   1 
ATOM   2717 C CG   . LEU A 1 182 ? -35.026 21.792 8.627   1.00 40.17  ? 182 LEU A CG   1 
ATOM   2718 C CD1  . LEU A 1 182 ? -33.966 22.678 8.009   1.00 48.65  ? 182 LEU A CD1  1 
ATOM   2719 C CD2  . LEU A 1 182 ? -34.442 20.567 9.268   1.00 47.16  ? 182 LEU A CD2  1 
ATOM   2720 H H    . LEU A 1 182 ? -37.771 21.969 7.787   1.00 47.47  ? 182 LEU A H    1 
ATOM   2721 H HA   . LEU A 1 182 ? -37.517 23.695 9.824   1.00 52.80  ? 182 LEU A HA   1 
ATOM   2722 H HB2  . LEU A 1 182 ? -35.172 23.275 10.029  1.00 52.64  ? 182 LEU A HB2  1 
ATOM   2723 H HB3  . LEU A 1 182 ? -35.995 21.974 10.420  1.00 52.64  ? 182 LEU A HB3  1 
ATOM   2724 H HG   . LEU A 1 182 ? -35.614 21.505 7.911   1.00 48.25  ? 182 LEU A HG   1 
ATOM   2725 H HD11 . LEU A 1 182 ? -34.385 23.271 7.366   1.00 58.43  ? 182 LEU A HD11 1 
ATOM   2726 H HD12 . LEU A 1 182 ? -33.308 22.120 7.565   1.00 58.43  ? 182 LEU A HD12 1 
ATOM   2727 H HD13 . LEU A 1 182 ? -33.541 23.197 8.710   1.00 58.43  ? 182 LEU A HD13 1 
ATOM   2728 H HD21 . LEU A 1 182 ? -33.715 20.833 9.852   1.00 56.64  ? 182 LEU A HD21 1 
ATOM   2729 H HD22 . LEU A 1 182 ? -34.109 19.976 8.574   1.00 56.64  ? 182 LEU A HD22 1 
ATOM   2730 H HD23 . LEU A 1 182 ? -35.133 20.120 9.781   1.00 56.64  ? 182 LEU A HD23 1 
ATOM   2731 N N    . LYS A 1 183 ? -36.125 25.340 8.547   1.00 33.82  ? 183 LYS A N    1 
ATOM   2732 C CA   . LYS A 1 183 ? -35.612 26.412 7.724   1.00 40.22  ? 183 LYS A CA   1 
ATOM   2733 C C    . LYS A 1 183 ? -34.268 26.751 8.306   1.00 41.71  ? 183 LYS A C    1 
ATOM   2734 O O    . LYS A 1 183 ? -34.197 27.057 9.498   1.00 38.54  ? 183 LYS A O    1 
ATOM   2735 C CB   . LYS A 1 183 ? -36.525 27.642 7.718   1.00 34.75  ? 183 LYS A CB   1 
ATOM   2736 C CG   . LYS A 1 183 ? -36.225 28.492 6.458   1.00 36.43  ? 183 LYS A CG   1 
ATOM   2737 C CD   . LYS A 1 183 ? -37.165 29.697 6.310   1.00 32.86  ? 183 LYS A CD   1 
ATOM   2738 C CE   . LYS A 1 183 ? -36.559 30.757 5.339   1.00 29.65  ? 183 LYS A CE   1 
ATOM   2739 N NZ   . LYS A 1 183 ? -36.570 30.282 3.943   1.00 28.43  ? 183 LYS A NZ   1 
ATOM   2740 H H    . LYS A 1 183 ? -36.043 25.500 9.388   1.00 40.63  ? 183 LYS A H    1 
ATOM   2741 H HA   . LYS A 1 183 ? -35.533 26.127 6.800   1.00 48.31  ? 183 LYS A HA   1 
ATOM   2742 H HB2  . LYS A 1 183 ? -37.454 27.363 7.696   1.00 41.75  ? 183 LYS A HB2  1 
ATOM   2743 H HB3  . LYS A 1 183 ? -36.359 28.180 8.508   1.00 41.75  ? 183 LYS A HB3  1 
ATOM   2744 H HG2  . LYS A 1 183 ? -35.317 28.827 6.512   1.00 43.76  ? 183 LYS A HG2  1 
ATOM   2745 H HG3  . LYS A 1 183 ? -36.327 27.936 5.670   1.00 43.76  ? 183 LYS A HG3  1 
ATOM   2746 H HD2  . LYS A 1 183 ? -38.016 29.401 5.952   1.00 39.49  ? 183 LYS A HD2  1 
ATOM   2747 H HD3  . LYS A 1 183 ? -37.297 30.113 7.177   1.00 39.49  ? 183 LYS A HD3  1 
ATOM   2748 H HE2  . LYS A 1 183 ? -37.082 31.572 5.388   1.00 35.63  ? 183 LYS A HE2  1 
ATOM   2749 H HE3  . LYS A 1 183 ? -35.640 30.936 5.593   1.00 35.63  ? 183 LYS A HE3  1 
ATOM   2750 H HZ1  . LYS A 1 183 ? -36.238 30.909 3.406   1.00 34.17  ? 183 LYS A HZ1  1 
ATOM   2751 H HZ2  . LYS A 1 183 ? -36.075 29.546 3.868   1.00 34.17  ? 183 LYS A HZ2  1 
ATOM   2752 H HZ3  . LYS A 1 183 ? -37.403 30.097 3.691   1.00 34.17  ? 183 LYS A HZ3  1 
ATOM   2753 N N    . CYS A 1 184 ? -33.211 26.672 7.483   1.00 41.37  ? 184 CYS A N    1 
ATOM   2754 C CA   . CYS A 1 184 ? -31.845 26.860 7.960   1.00 40.32  ? 184 CYS A CA   1 
ATOM   2755 C C    . CYS A 1 184 ? -31.434 28.328 7.924   1.00 40.82  ? 184 CYS A C    1 
ATOM   2756 O O    . CYS A 1 184 ? -31.987 29.160 7.175   1.00 37.34  ? 184 CYS A O    1 
ATOM   2757 C CB   . CYS A 1 184 ? -30.863 26.047 7.135   1.00 42.93  ? 184 CYS A CB   1 
ATOM   2758 S SG   . CYS A 1 184 ? -31.163 24.287 7.321   1.00 51.51  ? 184 CYS A SG   1 
ATOM   2759 H H    . CYS A 1 184 ? -33.266 26.509 6.641   1.00 49.70  ? 184 CYS A H    1 
ATOM   2760 H HA   . CYS A 1 184 ? -31.806 26.556 8.881   1.00 48.43  ? 184 CYS A HA   1 
ATOM   2761 H HB2  . CYS A 1 184 ? -30.962 26.279 6.198   1.00 51.57  ? 184 CYS A HB2  1 
ATOM   2762 H HB3  . CYS A 1 184 ? -29.959 26.238 7.430   1.00 51.57  ? 184 CYS A HB3  1 
ATOM   2763 H HG   . CYS A 1 184 ? -30.494 23.690 6.523   1.00 61.86  ? 184 CYS A HG   1 
ATOM   2764 N N    . VAL A 1 185 ? -30.465 28.639 8.793   1.00 35.34  ? 185 VAL A N    1 
ATOM   2765 C CA   . VAL A 1 185 ? -29.841 29.952 8.841   1.00 40.68  ? 185 VAL A CA   1 
ATOM   2766 C C    . VAL A 1 185 ? -29.267 30.351 7.491   1.00 44.21  ? 185 VAL A C    1 
ATOM   2767 O O    . VAL A 1 185 ? -29.302 31.529 7.133   1.00 41.28  ? 185 VAL A O    1 
ATOM   2768 C CB   . VAL A 1 185 ? -28.751 29.981 9.903   1.00 37.08  ? 185 VAL A CB   1 
ATOM   2769 C CG1  . VAL A 1 185 ? -27.922 31.239 9.715   1.00 43.92  ? 185 VAL A CG1  1 
ATOM   2770 C CG2  . VAL A 1 185 ? -29.395 29.915 11.276  1.00 40.00  ? 185 VAL A CG2  1 
ATOM   2771 H H    . VAL A 1 185 ? -30.148 28.092 9.375   1.00 42.46  ? 185 VAL A H    1 
ATOM   2772 H HA   . VAL A 1 185 ? -30.533 30.591 9.075   1.00 48.87  ? 185 VAL A HA   1 
ATOM   2773 H HB   . VAL A 1 185 ? -28.155 29.219 9.825   1.00 44.54  ? 185 VAL A HB   1 
ATOM   2774 H HG11 . VAL A 1 185 ? -27.486 31.458 10.553  1.00 52.75  ? 185 VAL A HG11 1 
ATOM   2775 H HG12 . VAL A 1 185 ? -27.256 31.079 9.028   1.00 52.75  ? 185 VAL A HG12 1 
ATOM   2776 H HG13 . VAL A 1 185 ? -28.506 31.965 9.446   1.00 52.75  ? 185 VAL A HG13 1 
ATOM   2777 H HG21 . VAL A 1 185 ? -30.179 29.346 11.230  1.00 48.05  ? 185 VAL A HG21 1 
ATOM   2778 H HG22 . VAL A 1 185 ? -28.756 29.547 11.907  1.00 48.05  ? 185 VAL A HG22 1 
ATOM   2779 H HG23 . VAL A 1 185 ? -29.651 30.810 11.548  1.00 48.05  ? 185 VAL A HG23 1 
ATOM   2780 N N    . SER A 1 186 ? -28.743 29.389 6.730   1.00 32.76  ? 186 SER A N    1 
ATOM   2781 C CA   . SER A 1 186 ? -28.058 29.625 5.480   1.00 37.16  ? 186 SER A CA   1 
ATOM   2782 C C    . SER A 1 186 ? -28.971 29.457 4.280   1.00 38.61  ? 186 SER A C    1 
ATOM   2783 O O    . SER A 1 186 ? -28.483 29.416 3.143   1.00 40.00  ? 186 SER A O    1 
ATOM   2784 C CB   . SER A 1 186 ? -26.870 28.655 5.364   1.00 47.32  ? 186 SER A CB   1 
ATOM   2785 O OG   . SER A 1 186 ? -27.329 27.443 4.764   1.00 52.94  ? 186 SER A OG   1 
ATOM   2786 H H    . SER A 1 186 ? -28.779 28.554 6.935   1.00 39.36  ? 186 SER A H    1 
ATOM   2787 H HA   . SER A 1 186 ? -27.720 30.534 5.472   1.00 44.64  ? 186 SER A HA   1 
ATOM   2788 H HB2  . SER A 1 186 ? -26.181 29.051 4.808   1.00 56.83  ? 186 SER A HB2  1 
ATOM   2789 H HB3  . SER A 1 186 ? -26.517 28.466 6.247   1.00 56.83  ? 186 SER A HB3  1 
ATOM   2790 H HG   . SER A 1 186 ? -26.705 26.882 4.736   1.00 63.58  ? 186 SER A HG   1 
ATOM   2791 N N    . ASP A 1 187 ? -30.276 29.318 4.501   1.00 43.03  ? 187 ASP A N    1 
ATOM   2792 C CA   . ASP A 1 187 ? -31.282 29.501 3.464   1.00 40.57  ? 187 ASP A CA   1 
ATOM   2793 C C    . ASP A 1 187 ? -31.531 31.013 3.280   1.00 31.19  ? 187 ASP A C    1 
ATOM   2794 O O    . ASP A 1 187 ? -31.052 31.857 4.040   1.00 26.52  ? 187 ASP A O    1 
ATOM   2795 C CB   . ASP A 1 187 ? -32.532 28.687 3.874   1.00 36.47  ? 187 ASP A CB   1 
ATOM   2796 C CG   . ASP A 1 187 ? -33.568 28.519 2.786   1.00 37.38  ? 187 ASP A CG   1 
ATOM   2797 O OD1  . ASP A 1 187 ? -33.396 28.838 1.592   1.00 40.27  ? 187 ASP A OD1  1 
ATOM   2798 O OD2  . ASP A 1 187 ? -34.646 28.047 3.193   1.00 40.15  ? 187 ASP A OD2  1 
ATOM   2799 H H    . ASP A 1 187 ? -30.612 29.112 5.266   1.00 51.68  ? 187 ASP A H    1 
ATOM   2800 H HA   . ASP A 1 187 ? -31.011 29.171 2.592   1.00 48.73  ? 187 ASP A HA   1 
ATOM   2801 H HB2  . ASP A 1 187 ? -32.247 27.800 4.143   1.00 43.82  ? 187 ASP A HB2  1 
ATOM   2802 H HB3  . ASP A 1 187 ? -32.962 29.138 4.617   1.00 43.82  ? 187 ASP A HB3  1 
ATOM   2803 N N    . SER A 1 188 ? -32.231 31.355 2.219   1.00 32.01  ? 188 SER A N    1 
ATOM   2804 C CA   . SER A 1 188 ? -32.718 32.716 2.061   1.00 35.35  ? 188 SER A CA   1 
ATOM   2805 C C    . SER A 1 188 ? -33.919 32.951 2.968   1.00 38.23  ? 188 SER A C    1 
ATOM   2806 O O    . SER A 1 188 ? -34.907 32.221 2.899   1.00 36.22  ? 188 SER A O    1 
ATOM   2807 C CB   . SER A 1 188 ? -33.155 32.951 0.624   1.00 35.80  ? 188 SER A CB   1 
ATOM   2808 O OG   . SER A 1 188 ? -33.841 34.198 0.519   1.00 38.89  ? 188 SER A OG   1 
ATOM   2809 H H    . SER A 1 188 ? -32.439 30.823 1.576   1.00 38.46  ? 188 SER A H    1 
ATOM   2810 H HA   . SER A 1 188 ? -32.007 33.332 2.294   1.00 42.47  ? 188 SER A HA   1 
ATOM   2811 H HB2  . SER A 1 188 ? -32.372 32.969 0.052   1.00 43.02  ? 188 SER A HB2  1 
ATOM   2812 H HB3  . SER A 1 188 ? -33.750 32.235 0.351   1.00 43.02  ? 188 SER A HB3  1 
ATOM   2813 H HG   . SER A 1 188 ? -33.290 34.831 0.540   1.00 46.72  ? 188 SER A HG   1 
ATOM   2814 N N    . TRP A 1 189 ? -33.857 34.006 3.758   1.00 36.46  ? 189 TRP A N    1 
ATOM   2815 C CA   . TRP A 1 189 ? -34.972 34.522 4.526   1.00 35.64  ? 189 TRP A CA   1 
ATOM   2816 C C    . TRP A 1 189 ? -35.644 35.684 3.804   1.00 37.10  ? 189 TRP A C    1 
ATOM   2817 O O    . TRP A 1 189 ? -36.340 36.497 4.417   1.00 39.58  ? 189 TRP A O    1 
ATOM   2818 C CB   . TRP A 1 189 ? -34.457 34.896 5.916   1.00 33.98  ? 189 TRP A CB   1 
ATOM   2819 C CG   . TRP A 1 189 ? -34.196 33.626 6.669   1.00 33.95  ? 189 TRP A CG   1 
ATOM   2820 C CD1  . TRP A 1 189 ? -33.101 32.787 6.540   1.00 43.29  ? 189 TRP A CD1  1 
ATOM   2821 C CD2  . TRP A 1 189 ? -35.072 32.992 7.577   1.00 36.86  ? 189 TRP A CD2  1 
ATOM   2822 N NE1  . TRP A 1 189 ? -33.243 31.680 7.358   1.00 39.77  ? 189 TRP A NE1  1 
ATOM   2823 C CE2  . TRP A 1 189 ? -34.441 31.788 8.006   1.00 37.83  ? 189 TRP A CE2  1 
ATOM   2824 C CE3  . TRP A 1 189 ? -36.322 33.330 8.109   1.00 35.36  ? 189 TRP A CE3  1 
ATOM   2825 C CZ2  . TRP A 1 189 ? -35.019 30.935 8.921   1.00 38.04  ? 189 TRP A CZ2  1 
ATOM   2826 C CZ3  . TRP A 1 189 ? -36.911 32.458 8.998   1.00 41.31  ? 189 TRP A CZ3  1 
ATOM   2827 C CH2  . TRP A 1 189 ? -36.247 31.280 9.417   1.00 41.45  ? 189 TRP A CH2  1 
ATOM   2828 H H    . TRP A 1 189 ? -33.139 34.466 3.872   1.00 43.80  ? 189 TRP A H    1 
ATOM   2829 H HA   . TRP A 1 189 ? -35.663 33.852 4.647   1.00 42.82  ? 189 TRP A HA   1 
ATOM   2830 H HB2  . TRP A 1 189 ? -33.632 35.400 5.842   1.00 40.83  ? 189 TRP A HB2  1 
ATOM   2831 H HB3  . TRP A 1 189 ? -35.124 35.418 6.389   1.00 40.83  ? 189 TRP A HB3  1 
ATOM   2832 H HD1  . TRP A 1 189 ? -32.373 32.945 5.982   1.00 52.00  ? 189 TRP A HD1  1 
ATOM   2833 H HE1  . TRP A 1 189 ? -32.678 31.038 7.444   1.00 47.77  ? 189 TRP A HE1  1 
ATOM   2834 H HE3  . TRP A 1 189 ? -36.743 34.123 7.868   1.00 42.48  ? 189 TRP A HE3  1 
ATOM   2835 H HZ2  . TRP A 1 189 ? -34.591 30.155 9.192   1.00 45.70  ? 189 TRP A HZ2  1 
ATOM   2836 H HZ3  . TRP A 1 189 ? -37.759 32.646 9.328   1.00 49.62  ? 189 TRP A HZ3  1 
ATOM   2837 H HH2  . TRP A 1 189 ? -36.655 30.728 10.044  1.00 49.79  ? 189 TRP A HH2  1 
ATOM   2838 N N    . LEU A 1 190 ? -35.463 35.759 2.490   1.00 36.82  ? 190 LEU A N    1 
ATOM   2839 C CA   . LEU A 1 190 ? -36.364 36.516 1.635   1.00 38.53  ? 190 LEU A CA   1 
ATOM   2840 C C    . LEU A 1 190 ? -37.455 35.644 1.059   1.00 39.17  ? 190 LEU A C    1 
ATOM   2841 O O    . LEU A 1 190 ? -38.452 36.171 0.543   1.00 36.92  ? 190 LEU A O    1 
ATOM   2842 C CB   . LEU A 1 190 ? -35.569 37.157 0.484   1.00 38.31  ? 190 LEU A CB   1 
ATOM   2843 C CG   . LEU A 1 190 ? -34.730 38.379 0.876   1.00 39.57  ? 190 LEU A CG   1 
ATOM   2844 C CD1  . LEU A 1 190 ? -33.696 38.621 -0.259  1.00 39.01  ? 190 LEU A CD1  1 
ATOM   2845 C CD2  . LEU A 1 190 ? -35.552 39.631 1.083   1.00 41.42  ? 190 LEU A CD2  1 
ATOM   2846 H H    . LEU A 1 190 ? -34.820 35.376 2.067   1.00 44.24  ? 190 LEU A H    1 
ATOM   2847 H HA   . LEU A 1 190 ? -36.777 37.230 2.144   1.00 46.28  ? 190 LEU A HA   1 
ATOM   2848 H HB2  . LEU A 1 190 ? -34.962 36.492 0.123   1.00 46.02  ? 190 LEU A HB2  1 
ATOM   2849 H HB3  . LEU A 1 190 ? -36.195 37.441 -0.199  1.00 46.02  ? 190 LEU A HB3  1 
ATOM   2850 H HG   . LEU A 1 190 ? -34.300 38.201 1.727   1.00 47.54  ? 190 LEU A HG   1 
ATOM   2851 H HD11 . LEU A 1 190 ? -33.051 39.283 0.037   1.00 46.86  ? 190 LEU A HD11 1 
ATOM   2852 H HD12 . LEU A 1 190 ? -33.244 37.786 -0.457  1.00 46.86  ? 190 LEU A HD12 1 
ATOM   2853 H HD13 . LEU A 1 190 ? -34.161 38.941 -1.047  1.00 46.86  ? 190 LEU A HD13 1 
ATOM   2854 H HD21 . LEU A 1 190 ? -36.370 39.399 1.550   1.00 49.75  ? 190 LEU A HD21 1 
ATOM   2855 H HD22 . LEU A 1 190 ? -35.038 40.263 1.610   1.00 49.75  ? 190 LEU A HD22 1 
ATOM   2856 H HD23 . LEU A 1 190 ? -35.763 40.017 0.218   1.00 49.75  ? 190 LEU A HD23 1 
ATOM   2857 N N    . LYS A 1 191 ? -37.320 34.328 1.173   1.00 33.08  ? 191 LYS A N    1 
ATOM   2858 C CA   . LYS A 1 191 ? -38.193 33.413 0.484   1.00 35.70  ? 191 LYS A CA   1 
ATOM   2859 C C    . LYS A 1 191 ? -38.748 32.370 1.444   1.00 33.74  ? 191 LYS A C    1 
ATOM   2860 O O    . LYS A 1 191 ? -38.132 32.062 2.478   1.00 33.00  ? 191 LYS A O    1 
ATOM   2861 C CB   . LYS A 1 191 ? -37.415 32.773 -0.666  1.00 38.26  ? 191 LYS A CB   1 
ATOM   2862 C CG   . LYS A 1 191 ? -37.059 33.764 -1.764  1.00 35.37  ? 191 LYS A CG   1 
ATOM   2863 C CD   . LYS A 1 191 ? -36.491 33.091 -3.004  1.00 37.96  ? 191 LYS A CD   1 
ATOM   2864 C CE   . LYS A 1 191 ? -35.363 32.178 -2.607  1.00 37.87  ? 191 LYS A CE   1 
ATOM   2865 N NZ   . LYS A 1 191 ? -34.301 31.924 -3.612  1.00 39.23  ? 191 LYS A NZ   1 
ATOM   2866 H H    . LYS A 1 191 ? -36.718 33.944 1.652   1.00 39.74  ? 191 LYS A H    1 
ATOM   2867 H HA   . LYS A 1 191 ? -38.974 33.866 0.129   1.00 42.90  ? 191 LYS A HA   1 
ATOM   2868 H HB2  . LYS A 1 191 ? -36.589 32.401 -0.319  1.00 45.97  ? 191 LYS A HB2  1 
ATOM   2869 H HB3  . LYS A 1 191 ? -37.955 32.070 -1.060  1.00 45.97  ? 191 LYS A HB3  1 
ATOM   2870 H HG2  . LYS A 1 191 ? -37.858 34.247 -2.025  1.00 42.49  ? 191 LYS A HG2  1 
ATOM   2871 H HG3  . LYS A 1 191 ? -36.392 34.382 -1.428  1.00 42.49  ? 191 LYS A HG3  1 
ATOM   2872 H HD2  . LYS A 1 191 ? -37.182 32.565 -3.438  1.00 45.60  ? 191 LYS A HD2  1 
ATOM   2873 H HD3  . LYS A 1 191 ? -36.151 33.762 -3.616  1.00 45.60  ? 191 LYS A HD3  1 
ATOM   2874 H HE2  . LYS A 1 191 ? -34.927 32.564 -1.832  1.00 45.50  ? 191 LYS A HE2  1 
ATOM   2875 H HE3  . LYS A 1 191 ? -35.744 31.316 -2.379  1.00 45.50  ? 191 LYS A HE3  1 
ATOM   2876 H HZ1  . LYS A 1 191 ? -34.667 31.749 -4.404  1.00 47.12  ? 191 LYS A HZ1  1 
ATOM   2877 H HZ2  . LYS A 1 191 ? -33.807 31.227 -3.362  1.00 47.12  ? 191 LYS A HZ2  1 
ATOM   2878 H HZ3  . LYS A 1 191 ? -33.776 32.638 -3.687  1.00 47.12  ? 191 LYS A HZ3  1 
ATOM   2879 N N    . ASP A 1 192 ? -39.913 31.838 1.101   1.00 31.62  ? 192 ASP A N    1 
ATOM   2880 C CA   . ASP A 1 192 ? -40.592 30.885 1.982   1.00 37.39  ? 192 ASP A CA   1 
ATOM   2881 C C    . ASP A 1 192 ? -40.231 29.447 1.643   1.00 35.51  ? 192 ASP A C    1 
ATOM   2882 O O    . ASP A 1 192 ? -41.092 28.558 1.557   1.00 35.20  ? 192 ASP A O    1 
ATOM   2883 C CB   . ASP A 1 192 ? -42.110 31.118 1.940   1.00 37.21  ? 192 ASP A CB   1 
ATOM   2884 C CG   . ASP A 1 192 ? -42.723 30.924 0.552   1.00 36.94  ? 192 ASP A CG   1 
ATOM   2885 O OD1  . ASP A 1 192 ? -42.131 31.329 -0.441  1.00 34.62  ? 192 ASP A OD1  1 
ATOM   2886 O OD2  . ASP A 1 192 ? -43.875 30.369 0.437   1.00 33.37  ? 192 ASP A OD2  1 
ATOM   2887 H H    . ASP A 1 192 ? -40.331 32.010 0.370   1.00 38.00  ? 192 ASP A H    1 
ATOM   2888 H HA   . ASP A 1 192 ? -40.301 31.044 2.894   1.00 44.92  ? 192 ASP A HA   1 
ATOM   2889 H HB2  . ASP A 1 192 ? -42.539 30.492 2.543   1.00 44.71  ? 192 ASP A HB2  1 
ATOM   2890 H HB3  . ASP A 1 192 ? -42.294 32.028 2.220   1.00 44.71  ? 192 ASP A HB3  1 
ATOM   2891 N N    . SER A 1 193 ? -38.945 29.181 1.422   1.00 30.67  ? 193 SER A N    1 
ATOM   2892 C CA   . SER A 1 193 ? -38.452 27.836 1.216   1.00 29.11  ? 193 SER A CA   1 
ATOM   2893 C C    . SER A 1 193 ? -38.204 27.213 2.584   1.00 27.47  ? 193 SER A C    1 
ATOM   2894 O O    . SER A 1 193 ? -38.205 27.888 3.615   1.00 29.14  ? 193 SER A O    1 
ATOM   2895 C CB   . SER A 1 193 ? -37.170 27.834 0.365   1.00 36.16  ? 193 SER A CB   1 
ATOM   2896 O OG   . SER A 1 193 ? -36.227 28.786 0.833   1.00 27.68  ? 193 SER A OG   1 
ATOM   2897 H H    . SER A 1 193 ? -38.330 29.782 1.386   1.00 36.86  ? 193 SER A H    1 
ATOM   2898 H HA   . SER A 1 193 ? -39.102 27.307 0.727   1.00 34.98  ? 193 SER A HA   1 
ATOM   2899 H HB2  . SER A 1 193 ? -36.769 26.951 0.406   1.00 43.44  ? 193 SER A HB2  1 
ATOM   2900 H HB3  . SER A 1 193 ? -37.403 28.050 -0.552  1.00 43.44  ? 193 SER A HB3  1 
ATOM   2901 H HG   . SER A 1 193 ? -35.766 28.454 1.452   1.00 33.26  ? 193 SER A HG   1 
ATOM   2902 N N    . ALA A 1 194 ? -38.048 25.901 2.590   1.00 32.56  ? 194 ALA A N    1 
ATOM   2903 C CA   . ALA A 1 194 ? -37.833 25.129 3.803   1.00 32.69  ? 194 ALA A CA   1 
ATOM   2904 C C    . ALA A 1 194 ? -37.328 23.762 3.362   1.00 37.61  ? 194 ALA A C    1 
ATOM   2905 O O    . ALA A 1 194 ? -37.390 23.408 2.172   1.00 39.28  ? 194 ALA A O    1 
ATOM   2906 C CB   . ALA A 1 194 ? -39.139 25.068 4.621   1.00 35.37  ? 194 ALA A CB   1 
ATOM   2907 H H    . ALA A 1 194 ? -38.062 25.415 1.880   1.00 39.13  ? 194 ALA A H    1 
ATOM   2908 H HA   . ALA A 1 194 ? -37.155 25.519 4.377   1.00 39.28  ? 194 ALA A HA   1 
ATOM   2909 H HB1  . ALA A 1 194 ? -39.394 25.968 4.877   1.00 42.50  ? 194 ALA A HB1  1 
ATOM   2910 H HB2  . ALA A 1 194 ? -39.835 24.669 4.076   1.00 42.50  ? 194 ALA A HB2  1 
ATOM   2911 H HB3  . ALA A 1 194 ? -38.990 24.529 5.414   1.00 42.50  ? 194 ALA A HB3  1 
ATOM   2912 N N    . ILE A 1 195 ? -36.826 22.987 4.328   1.00 38.92  ? 195 ILE A N    1 
ATOM   2913 C CA   . ILE A 1 195 ? -36.360 21.623 4.070   1.00 36.85  ? 195 ILE A CA   1 
ATOM   2914 C C    . ILE A 1 195 ? -37.173 20.637 4.904   1.00 33.90  ? 195 ILE A C    1 
ATOM   2915 O O    . ILE A 1 195 ? -37.380 20.840 6.107   1.00 35.82  ? 195 ILE A O    1 
ATOM   2916 C CB   . ILE A 1 195 ? -34.856 21.489 4.371   1.00 39.87  ? 195 ILE A CB   1 
ATOM   2917 C CG1  . ILE A 1 195 ? -34.067 22.380 3.407   1.00 35.14  ? 195 ILE A CG1  1 
ATOM   2918 C CG2  . ILE A 1 195 ? -34.397 20.077 4.212   1.00 41.22  ? 195 ILE A CG2  1 
ATOM   2919 C CD1  . ILE A 1 195 ? -32.552 22.488 3.655   1.00 41.72  ? 195 ILE A CD1  1 
ATOM   2920 H H    . ILE A 1 195 ? -36.745 23.233 5.148   1.00 46.76  ? 195 ILE A H    1 
ATOM   2921 H HA   . ILE A 1 195 ? -36.519 21.406 3.138   1.00 44.27  ? 195 ILE A HA   1 
ATOM   2922 H HB   . ILE A 1 195 ? -34.706 21.764 5.290   1.00 47.90  ? 195 ILE A HB   1 
ATOM   2923 H HG12 . ILE A 1 195 ? -34.183 22.030 2.510   1.00 42.22  ? 195 ILE A HG12 1 
ATOM   2924 H HG13 . ILE A 1 195 ? -34.428 23.278 3.462   1.00 42.22  ? 195 ILE A HG13 1 
ATOM   2925 H HG21 . ILE A 1 195 ? -34.561 19.793 3.299   1.00 49.52  ? 195 ILE A HG21 1 
ATOM   2926 H HG22 . ILE A 1 195 ? -33.448 20.029 4.408   1.00 49.52  ? 195 ILE A HG22 1 
ATOM   2927 H HG23 . ILE A 1 195 ? -34.890 19.513 4.828   1.00 49.52  ? 195 ILE A HG23 1 
ATOM   2928 H HD11 . ILE A 1 195 ? -32.183 23.165 3.067   1.00 50.11  ? 195 ILE A HD11 1 
ATOM   2929 H HD12 . ILE A 1 195 ? -32.400 22.735 4.580   1.00 50.11  ? 195 ILE A HD12 1 
ATOM   2930 H HD13 . ILE A 1 195 ? -32.140 21.629 3.470   1.00 50.11  ? 195 ILE A HD13 1 
ATOM   2931 N N    . MET A 1 196 ? -37.641 19.583 4.252   1.00 36.31  ? 196 MET A N    1 
ATOM   2932 C CA   . MET A 1 196 ? -38.179 18.410 4.906   1.00 38.23  ? 196 MET A CA   1 
ATOM   2933 C C    . MET A 1 196 ? -37.073 17.376 5.022   1.00 37.23  ? 196 MET A C    1 
ATOM   2934 O O    . MET A 1 196 ? -36.514 16.959 4.007   1.00 41.03  ? 196 MET A O    1 
ATOM   2935 C CB   . MET A 1 196 ? -39.347 17.827 4.095   1.00 37.92  ? 196 MET A CB   1 
ATOM   2936 C CG   . MET A 1 196 ? -40.097 16.689 4.791   1.00 38.59  ? 196 MET A CG   1 
ATOM   2937 S SD   . MET A 1 196 ? -40.927 15.546 3.649   1.00 42.70  ? 196 MET A SD   1 
ATOM   2938 C CE   . MET A 1 196 ? -39.519 14.669 3.097   1.00 44.52  ? 196 MET A CE   1 
ATOM   2939 H H    . MET A 1 196 ? -37.657 19.525 3.394   1.00 43.62  ? 196 MET A H    1 
ATOM   2940 H HA   . MET A 1 196 ? -38.506 18.654 5.786   1.00 45.92  ? 196 MET A HA   1 
ATOM   2941 H HB2  . MET A 1 196 ? -39.986 18.536 3.922   1.00 45.55  ? 196 MET A HB2  1 
ATOM   2942 H HB3  . MET A 1 196 ? -39.000 17.481 3.258   1.00 45.55  ? 196 MET A HB3  1 
ATOM   2943 H HG2  . MET A 1 196 ? -39.464 16.175 5.315   1.00 46.35  ? 196 MET A HG2  1 
ATOM   2944 H HG3  . MET A 1 196 ? -40.775 17.071 5.370   1.00 46.35  ? 196 MET A HG3  1 
ATOM   2945 H HE1  . MET A 1 196 ? -38.905 15.291 2.676   1.00 53.48  ? 196 MET A HE1  1 
ATOM   2946 H HE2  . MET A 1 196 ? -39.797 13.995 2.458   1.00 53.48  ? 196 MET A HE2  1 
ATOM   2947 H HE3  . MET A 1 196 ? -39.091 14.246 3.858   1.00 53.48  ? 196 MET A HE3  1 
ATOM   2948 N N    . VAL A 1 197 ? -36.799 16.925 6.241   1.00 39.47  ? 197 VAL A N    1 
ATOM   2949 C CA   . VAL A 1 197 ? -35.939 15.760 6.478   1.00 47.04  ? 197 VAL A CA   1 
ATOM   2950 C C    . VAL A 1 197 ? -36.795 14.638 7.032   1.00 46.73  ? 197 VAL A C    1 
ATOM   2951 O O    . VAL A 1 197 ? -37.235 14.696 8.184   1.00 48.45  ? 197 VAL A O    1 
ATOM   2952 C CB   . VAL A 1 197 ? -34.797 16.069 7.438   1.00 40.88  ? 197 VAL A CB   1 
ATOM   2953 C CG1  . VAL A 1 197 ? -34.039 14.808 7.751   1.00 45.44  ? 197 VAL A CG1  1 
ATOM   2954 C CG2  . VAL A 1 197 ? -33.930 17.094 6.817   1.00 43.77  ? 197 VAL A CG2  1 
ATOM   2955 H H    . VAL A 1 197 ? -37.103 17.280 6.962   1.00 47.42  ? 197 VAL A H    1 
ATOM   2956 H HA   . VAL A 1 197 ? -35.571 15.481 5.625   1.00 56.50  ? 197 VAL A HA   1 
ATOM   2957 H HB   . VAL A 1 197 ? -35.131 16.417 8.280   1.00 49.11  ? 197 VAL A HB   1 
ATOM   2958 H HG11 . VAL A 1 197 ? -33.096 15.019 7.835   1.00 54.58  ? 197 VAL A HG11 1 
ATOM   2959 H HG12 . VAL A 1 197 ? -34.172 14.173 7.030   1.00 54.58  ? 197 VAL A HG12 1 
ATOM   2960 H HG13 . VAL A 1 197 ? -34.370 14.438 8.584   1.00 54.58  ? 197 VAL A HG13 1 
ATOM   2961 H HG21 . VAL A 1 197 ? -33.455 17.571 7.516   1.00 52.58  ? 197 VAL A HG21 1 
ATOM   2962 H HG22 . VAL A 1 197 ? -34.483 17.711 6.313   1.00 52.58  ? 197 VAL A HG22 1 
ATOM   2963 H HG23 . VAL A 1 197 ? -33.298 16.656 6.226   1.00 52.58  ? 197 VAL A HG23 1 
ATOM   2964 N N    . ALA A 1 198 ? -37.010 13.620 6.210   1.00 46.67  ? 198 ALA A N    1 
ATOM   2965 C CA   . ALA A 1 198 ? -37.633 12.374 6.610   1.00 46.78  ? 198 ALA A CA   1 
ATOM   2966 C C    . ALA A 1 198 ? -36.603 11.251 6.750   1.00 50.56  ? 198 ALA A C    1 
ATOM   2967 O O    . ALA A 1 198 ? -35.598 11.220 6.036   1.00 44.67  ? 198 ALA A O    1 
ATOM   2968 C CB   . ALA A 1 198 ? -38.677 11.987 5.576   1.00 41.85  ? 198 ALA A CB   1 
ATOM   2969 H H    . ALA A 1 198 ? -36.792 13.631 5.378   1.00 56.05  ? 198 ALA A H    1 
ATOM   2970 H HA   . ALA A 1 198 ? -38.053 12.482 7.478   1.00 56.19  ? 198 ALA A HA   1 
ATOM   2971 H HB1  . ALA A 1 198 ? -39.187 11.232 5.910   1.00 50.28  ? 198 ALA A HB1  1 
ATOM   2972 H HB2  . ALA A 1 198 ? -38.228 11.744 4.751   1.00 50.28  ? 198 ALA A HB2  1 
ATOM   2973 H HB3  . ALA A 1 198 ? -39.265 12.742 5.423   1.00 50.28  ? 198 ALA A HB3  1 
ATOM   2974 N N    . SER A 1 199 ? -36.863 10.331 7.687   1.00 50.02  ? 199 SER A N    1 
ATOM   2975 C CA   . SER A 1 199 ? -36.038 9.137  7.858   1.00 52.29  ? 199 SER A CA   1 
ATOM   2976 C C    . SER A 1 199 ? -36.893 7.972  8.379   1.00 51.37  ? 199 SER A C    1 
ATOM   2977 O O    . SER A 1 199 ? -38.020 8.155  8.847   1.00 43.98  ? 199 SER A O    1 
ATOM   2978 C CB   . SER A 1 199 ? -34.861 9.416  8.803   1.00 48.86  ? 199 SER A CB   1 
ATOM   2979 O OG   . SER A 1 199 ? -35.297 9.966  10.041  1.00 45.95  ? 199 SER A OG   1 
ATOM   2980 H H    . SER A 1 199 ? -37.519 10.379 8.241   1.00 60.08  ? 199 SER A H    1 
ATOM   2981 H HA   . SER A 1 199 ? -35.689 8.865  6.995   1.00 62.80  ? 199 SER A HA   1 
ATOM   2982 H HB2  . SER A 1 199 ? -34.397 8.583  8.978   1.00 58.68  ? 199 SER A HB2  1 
ATOM   2983 H HB3  . SER A 1 199 ? -34.261 10.047 8.376   1.00 58.68  ? 199 SER A HB3  1 
ATOM   2984 H HG   . SER A 1 199 ? -35.860 9.455  10.400  1.00 55.19  ? 199 SER A HG   1 
ATOM   2985 N N    . ASP A 1 200 ? -36.355 6.754  8.253   1.00 61.19  ? 200 ASP A N    1 
ATOM   2986 C CA   . ASP A 1 200 ? -37.013 5.545  8.749   1.00 55.44  ? 200 ASP A CA   1 
ATOM   2987 C C    . ASP A 1 200 ? -38.260 5.239  7.942   1.00 54.05  ? 200 ASP A C    1 
ATOM   2988 O O    . ASP A 1 200 ? -39.377 5.438  8.414   1.00 52.79  ? 200 ASP A O    1 
ATOM   2989 C CB   . ASP A 1 200 ? -37.352 5.690  10.230  1.00 68.98  ? 200 ASP A CB   1 
ATOM   2990 C CG   . ASP A 1 200 ? -36.108 5.833  11.077  1.00 88.56  ? 200 ASP A CG   1 
ATOM   2991 O OD1  . ASP A 1 200 ? -35.076 5.215  10.731  1.00 84.09  ? 200 ASP A OD1  1 
ATOM   2992 O OD2  . ASP A 1 200 ? -36.136 6.580  12.071  1.00 71.47  ? 200 ASP A OD2  1 
ATOM   2993 H H    . ASP A 1 200 ? -35.596 6.601  7.878   1.00 73.48  ? 200 ASP A H    1 
ATOM   2994 H HA   . ASP A 1 200 ? -36.407 4.793  8.655   1.00 66.58  ? 200 ASP A HA   1 
ATOM   2995 H HB2  . ASP A 1 200 ? -37.900 6.480  10.357  1.00 82.83  ? 200 ASP A HB2  1 
ATOM   2996 H HB3  . ASP A 1 200 ? -37.833 4.901  10.527  1.00 82.83  ? 200 ASP A HB3  1 
ATOM   2997 N N    . VAL A 1 201 ? -38.062 4.725  6.731   1.00 48.63  ? 201 VAL A N    1 
ATOM   2998 C CA   . VAL A 1 201 ? -39.148 4.505  5.800   1.00 41.48  ? 201 VAL A CA   1 
ATOM   2999 C C    . VAL A 1 201 ? -40.091 3.426  6.314   1.00 51.08  ? 201 VAL A C    1 
ATOM   3000 O O    . VAL A 1 201 ? -39.735 2.573  7.135   1.00 51.97  ? 201 VAL A O    1 
ATOM   3001 C CB   . VAL A 1 201 ? -38.549 4.112  4.444   1.00 53.27  ? 201 VAL A CB   1 
ATOM   3002 C CG1  . VAL A 1 201 ? -37.853 2.759  4.602   1.00 56.57  ? 201 VAL A CG1  1 
ATOM   3003 C CG2  . VAL A 1 201 ? -39.576 4.069  3.345   1.00 45.15  ? 201 VAL A CG2  1 
ATOM   3004 H H    . VAL A 1 201 ? -37.293 4.492  6.423   1.00 58.41  ? 201 VAL A H    1 
ATOM   3005 H HA   . VAL A 1 201 ? -39.675 5.314  5.711   1.00 49.83  ? 201 VAL A HA   1 
ATOM   3006 H HB   . VAL A 1 201 ? -37.909 4.789  4.172   1.00 63.98  ? 201 VAL A HB   1 
ATOM   3007 H HG11 . VAL A 1 201 ? -37.560 2.660  5.521   1.00 67.93  ? 201 VAL A HG11 1 
ATOM   3008 H HG12 . VAL A 1 201 ? -38.479 2.054  4.376   1.00 67.93  ? 201 VAL A HG12 1 
ATOM   3009 H HG13 . VAL A 1 201 ? -37.089 2.726  4.005   1.00 67.93  ? 201 VAL A HG13 1 
ATOM   3010 H HG21 . VAL A 1 201 ? -40.219 4.782  3.485   1.00 54.23  ? 201 VAL A HG21 1 
ATOM   3011 H HG22 . VAL A 1 201 ? -39.131 4.188  2.492   1.00 54.23  ? 201 VAL A HG22 1 
ATOM   3012 H HG23 . VAL A 1 201 ? -40.026 3.210  3.367   1.00 54.23  ? 201 VAL A HG23 1 
ATOM   3013 N N    . TYR A 1 202 ? -41.310 3.451  5.789   1.00 56.47  ? 202 TYR A N    1 
ATOM   3014 C CA   . TYR A 1 202 ? -42.381 2.523  6.142   1.00 53.34  ? 202 TYR A CA   1 
ATOM   3015 C C    . TYR A 1 202 ? -42.810 1.861  4.837   1.00 57.92  ? 202 TYR A C    1 
ATOM   3016 O O    . TYR A 1 202 ? -43.620 2.417  4.085   1.00 52.29  ? 202 TYR A O    1 
ATOM   3017 C CB   . TYR A 1 202 ? -43.532 3.254  6.825   1.00 58.27  ? 202 TYR A CB   1 
ATOM   3018 C CG   . TYR A 1 202 ? -44.596 2.350  7.418   1.00 65.54  ? 202 TYR A CG   1 
ATOM   3019 C CD1  . TYR A 1 202 ? -44.249 1.257  8.221   1.00 65.82  ? 202 TYR A CD1  1 
ATOM   3020 C CD2  . TYR A 1 202 ? -45.950 2.598  7.194   1.00 59.44  ? 202 TYR A CD2  1 
ATOM   3021 C CE1  . TYR A 1 202 ? -45.215 0.433  8.767   1.00 71.43  ? 202 TYR A CE1  1 
ATOM   3022 C CE2  . TYR A 1 202 ? -46.928 1.787  7.745   1.00 65.93  ? 202 TYR A CE2  1 
ATOM   3023 C CZ   . TYR A 1 202 ? -46.547 0.704  8.526   1.00 75.08  ? 202 TYR A CZ   1 
ATOM   3024 O OH   . TYR A 1 202 ? -47.491 -0.111 9.073   1.00 79.29  ? 202 TYR A OH   1 
ATOM   3025 H H    . TYR A 1 202 ? -41.554 4.024  5.196   1.00 67.82  ? 202 TYR A H    1 
ATOM   3026 H HA   . TYR A 1 202 ? -42.064 1.844  6.758   1.00 64.06  ? 202 TYR A HA   1 
ATOM   3027 H HB2  . TYR A 1 202 ? -43.171 3.792  7.547   1.00 69.97  ? 202 TYR A HB2  1 
ATOM   3028 H HB3  . TYR A 1 202 ? -43.966 3.824  6.171   1.00 69.97  ? 202 TYR A HB3  1 
ATOM   3029 H HD1  . TYR A 1 202 ? -43.351 1.082  8.391   1.00 79.03  ? 202 TYR A HD1  1 
ATOM   3030 H HD2  . TYR A 1 202 ? -46.201 3.322  6.666   1.00 71.38  ? 202 TYR A HD2  1 
ATOM   3031 H HE1  . TYR A 1 202 ? -44.971 -0.296 9.290   1.00 85.77  ? 202 TYR A HE1  1 
ATOM   3032 H HE2  . TYR A 1 202 ? -47.829 1.965  7.594   1.00 79.17  ? 202 TYR A HE2  1 
ATOM   3033 H HH   . TYR A 1 202 ? -47.143 -0.601 9.659   1.00 95.20  ? 202 TYR A HH   1 
ATOM   3034 N N    . LYS A 1 203 ? -42.250 0.680  4.557   1.00 55.76  ? 203 LYS A N    1 
ATOM   3035 C CA   . LYS A 1 203 ? -42.398 0.093  3.231   1.00 59.67  ? 203 LYS A CA   1 
ATOM   3036 C C    . LYS A 1 203 ? -43.863 -0.101 2.864   1.00 56.63  ? 203 LYS A C    1 
ATOM   3037 O O    . LYS A 1 203 ? -44.257 0.105  1.710   1.00 55.82  ? 203 LYS A O    1 
ATOM   3038 C CB   . LYS A 1 203 ? -41.645 -1.237 3.175   1.00 79.33  ? 203 LYS A CB   1 
ATOM   3039 C CG   . LYS A 1 203 ? -41.636 -1.912 1.804   1.00 111.63 ? 203 LYS A CG   1 
ATOM   3040 C CD   . LYS A 1 203 ? -40.929 -1.044 0.782   1.00 103.71 ? 203 LYS A CD   1 
ATOM   3041 C CE   . LYS A 1 203 ? -40.170 -1.875 -0.224  1.00 130.02 ? 203 LYS A CE   1 
ATOM   3042 N NZ   . LYS A 1 203 ? -39.657 -0.987 -1.297  1.00 92.96  ? 203 LYS A NZ   1 
ATOM   3043 H H    . LYS A 1 203 ? -41.788 0.210  5.110   1.00 66.97  ? 203 LYS A H    1 
ATOM   3044 H HA   . LYS A 1 203 ? -42.011 0.694  2.575   1.00 71.66  ? 203 LYS A HA   1 
ATOM   3045 H HB2  . LYS A 1 203 ? -40.722 -1.079 3.427   1.00 95.24  ? 203 LYS A HB2  1 
ATOM   3046 H HB3  . LYS A 1 203 ? -42.059 -1.852 3.800   1.00 95.24  ? 203 LYS A HB3  1 
ATOM   3047 H HG2  . LYS A 1 203 ? -41.170 -2.761 1.863   1.00 134.01 ? 203 LYS A HG2  1 
ATOM   3048 H HG3  . LYS A 1 203 ? -42.549 -2.056 1.507   1.00 134.01 ? 203 LYS A HG3  1 
ATOM   3049 H HD2  . LYS A 1 203 ? -41.585 -0.512 0.304   1.00 124.51 ? 203 LYS A HD2  1 
ATOM   3050 H HD3  . LYS A 1 203 ? -40.298 -0.464 1.235   1.00 124.51 ? 203 LYS A HD3  1 
ATOM   3051 H HE2  . LYS A 1 203 ? -39.420 -2.313 0.208   1.00 156.08 ? 203 LYS A HE2  1 
ATOM   3052 H HE3  . LYS A 1 203 ? -40.760 -2.537 -0.617  1.00 156.08 ? 203 LYS A HE3  1 
ATOM   3053 H HZ1  . LYS A 1 203 ? -39.214 -1.466 -1.903  1.00 111.60 ? 203 LYS A HZ1  1 
ATOM   3054 H HZ2  . LYS A 1 203 ? -40.335 -0.571 -1.697  1.00 111.60 ? 203 LYS A HZ2  1 
ATOM   3055 H HZ3  . LYS A 1 203 ? -39.108 -0.378 -0.952  1.00 111.60 ? 203 LYS A HZ3  1 
ATOM   3056 N N    . LYS A 1 204 ? -44.683 -0.503 3.829   1.00 51.82  ? 204 LYS A N    1 
ATOM   3057 C CA   . LYS A 1 204 ? -46.079 -0.806 3.554   1.00 56.84  ? 204 LYS A CA   1 
ATOM   3058 C C    . LYS A 1 204 ? -46.717 0.300  2.738   1.00 52.49  ? 204 LYS A C    1 
ATOM   3059 O O    . LYS A 1 204 ? -47.412 0.059  1.744   1.00 51.79  ? 204 LYS A O    1 
ATOM   3060 C CB   . LYS A 1 204 ? -46.801 -0.977 4.886   1.00 57.52  ? 204 LYS A CB   1 
ATOM   3061 C CG   . LYS A 1 204 ? -48.300 -0.997 4.802   1.00 66.60  ? 204 LYS A CG   1 
ATOM   3062 C CD   . LYS A 1 204 ? -48.884 -1.197 6.200   1.00 68.39  ? 204 LYS A CD   1 
ATOM   3063 C CE   . LYS A 1 204 ? -50.365 -1.550 6.155   1.00 71.11  ? 204 LYS A CE   1 
ATOM   3064 N NZ   . LYS A 1 204 ? -51.122 -0.631 5.277   1.00 77.22  ? 204 LYS A NZ   1 
ATOM   3065 H H    . LYS A 1 204 ? -44.454 -0.609 4.651   1.00 62.24  ? 204 LYS A H    1 
ATOM   3066 H HA   . LYS A 1 204 ? -46.150 -1.629 3.045   1.00 68.26  ? 204 LYS A HA   1 
ATOM   3067 H HB2  . LYS A 1 204 ? -46.521 -1.818 5.280   1.00 69.08  ? 204 LYS A HB2  1 
ATOM   3068 H HB3  . LYS A 1 204 ? -46.553 -0.240 5.465   1.00 69.08  ? 204 LYS A HB3  1 
ATOM   3069 H HG2  . LYS A 1 204 ? -48.621 -0.154 4.445   1.00 79.97  ? 204 LYS A HG2  1 
ATOM   3070 H HG3  . LYS A 1 204 ? -48.588 -1.729 4.234   1.00 79.97  ? 204 LYS A HG3  1 
ATOM   3071 H HD2  . LYS A 1 204 ? -48.414 -1.921 6.642   1.00 82.12  ? 204 LYS A HD2  1 
ATOM   3072 H HD3  . LYS A 1 204 ? -48.783 -0.377 6.708   1.00 82.12  ? 204 LYS A HD3  1 
ATOM   3073 H HE2  . LYS A 1 204 ? -50.469 -2.451 5.813   1.00 85.38  ? 204 LYS A HE2  1 
ATOM   3074 H HE3  . LYS A 1 204 ? -50.736 -1.489 7.050   1.00 85.38  ? 204 LYS A HE3  1 
ATOM   3075 H HZ1  . LYS A 1 204 ? -51.996 -0.777 5.365   1.00 92.71  ? 204 LYS A HZ1  1 
ATOM   3076 H HZ2  . LYS A 1 204 ? -50.947 0.213  5.497   1.00 92.71  ? 204 LYS A HZ2  1 
ATOM   3077 H HZ3  . LYS A 1 204 ? -50.892 -0.763 4.428   1.00 92.71  ? 204 LYS A HZ3  1 
ATOM   3078 N N    . ASN A 1 205 ? -46.481 1.529  3.153   1.00 59.44  ? 205 ASN A N    1 
ATOM   3079 C CA   . ASN A 1 205 ? -47.148 2.661  2.550   1.00 53.86  ? 205 ASN A CA   1 
ATOM   3080 C C    . ASN A 1 205 ? -46.358 3.226  1.395   1.00 51.06  ? 205 ASN A C    1 
ATOM   3081 O O    . ASN A 1 205 ? -46.958 3.685  0.420   1.00 53.01  ? 205 ASN A O    1 
ATOM   3082 C CB   . ASN A 1 205 ? -47.389 3.721  3.607   1.00 47.05  ? 205 ASN A CB   1 
ATOM   3083 C CG   . ASN A 1 205 ? -48.629 3.438  4.407   1.00 58.19  ? 205 ASN A CG   1 
ATOM   3084 O OD1  . ASN A 1 205 ? -49.632 3.005  3.848   1.00 57.66  ? 205 ASN A OD1  1 
ATOM   3085 N ND2  . ASN A 1 205 ? -48.582 3.689  5.713   1.00 58.13  ? 205 ASN A ND2  1 
ATOM   3086 H H    . ASN A 1 205 ? -45.935 1.734  3.786   1.00 71.38  ? 205 ASN A H    1 
ATOM   3087 H HA   . ASN A 1 205 ? -48.015 2.398  2.205   1.00 64.68  ? 205 ASN A HA   1 
ATOM   3088 H HB2  . ASN A 1 205 ? -46.634 3.745  4.215   1.00 56.51  ? 205 ASN A HB2  1 
ATOM   3089 H HB3  . ASN A 1 205 ? -47.496 4.584  3.176   1.00 56.51  ? 205 ASN A HB3  1 
ATOM   3090 H HD21 . ASN A 1 205 ? -49.272 3.540  6.204   1.00 69.81  ? 205 ASN A HD21 1 
ATOM   3091 H HD22 . ASN A 1 205 ? -47.862 4.001  6.065   1.00 69.81  ? 205 ASN A HD22 1 
ATOM   3092 N N    . LEU A 1 206 ? -45.025 3.194  1.481   1.00 53.27  ? 206 LEU A N    1 
ATOM   3093 C CA   . LEU A 1 206 ? -44.250 3.515  0.302   1.00 55.64  ? 206 LEU A CA   1 
ATOM   3094 C C    . LEU A 1 206 ? -44.766 2.695  -0.874  1.00 54.94  ? 206 LEU A C    1 
ATOM   3095 O O    . LEU A 1 206 ? -45.035 3.241  -1.954  1.00 51.52  ? 206 LEU A O    1 
ATOM   3096 C CB   . LEU A 1 206 ? -42.768 3.275  0.573   1.00 49.69  ? 206 LEU A CB   1 
ATOM   3097 C CG   . LEU A 1 206 ? -41.889 3.710  -0.597  1.00 52.80  ? 206 LEU A CG   1 
ATOM   3098 C CD1  . LEU A 1 206 ? -42.079 5.164  -1.003  1.00 58.22  ? 206 LEU A CD1  1 
ATOM   3099 C CD2  . LEU A 1 206 ? -40.451 3.452  -0.238  1.00 55.23  ? 206 LEU A CD2  1 
ATOM   3100 H H    . LEU A 1 206 ? -44.572 2.996  2.185   1.00 63.97  ? 206 LEU A H    1 
ATOM   3101 H HA   . LEU A 1 206 ? -44.332 4.455  0.076   1.00 66.81  ? 206 LEU A HA   1 
ATOM   3102 H HB2  . LEU A 1 206 ? -42.502 3.781  1.356   1.00 59.68  ? 206 LEU A HB2  1 
ATOM   3103 H HB3  . LEU A 1 206 ? -42.623 2.328  0.725   1.00 59.68  ? 206 LEU A HB3  1 
ATOM   3104 H HG   . LEU A 1 206 ? -42.149 3.193  -1.376  1.00 63.42  ? 206 LEU A HG   1 
ATOM   3105 H HD11 . LEU A 1 206 ? -42.918 5.251  -1.482  1.00 69.91  ? 206 LEU A HD11 1 
ATOM   3106 H HD12 . LEU A 1 206 ? -41.343 5.432  -1.574  1.00 69.91  ? 206 LEU A HD12 1 
ATOM   3107 H HD13 . LEU A 1 206 ? -42.096 5.715  -0.204  1.00 69.91  ? 206 LEU A HD13 1 
ATOM   3108 H HD21 . LEU A 1 206 ? -39.881 3.829  -0.926  1.00 66.33  ? 206 LEU A HD21 1 
ATOM   3109 H HD22 . LEU A 1 206 ? -40.259 3.870  0.616   1.00 66.33  ? 206 LEU A HD22 1 
ATOM   3110 H HD23 . LEU A 1 206 ? -40.308 2.495  -0.177  1.00 66.33  ? 206 LEU A HD23 1 
ATOM   3111 N N    . ASP A 1 207 ? -45.035 1.404  -0.638  1.00 53.64  ? 207 ASP A N    1 
ATOM   3112 C CA   . ASP A 1 207 ? -45.490 0.531  -1.713  1.00 59.53  ? 207 ASP A CA   1 
ATOM   3113 C C    . ASP A 1 207 ? -46.897 0.899  -2.159  1.00 54.84  ? 207 ASP A C    1 
ATOM   3114 O O    . ASP A 1 207 ? -47.175 0.993  -3.364  1.00 45.93  ? 207 ASP A O    1 
ATOM   3115 C CB   . ASP A 1 207 ? -45.429 -0.929 -1.257  1.00 79.87  ? 207 ASP A CB   1 
ATOM   3116 C CG   . ASP A 1 207 ? -44.004 -1.392 -0.971  1.00 99.90  ? 207 ASP A CG   1 
ATOM   3117 O OD1  . ASP A 1 207 ? -43.063 -0.721 -1.450  1.00 84.18  ? 207 ASP A OD1  1 
ATOM   3118 O OD2  . ASP A 1 207 ? -43.831 -2.424 -0.278  1.00 92.56  ? 207 ASP A OD2  1 
ATOM   3119 H H    . ASP A 1 207 ? -44.962 1.019  0.127   1.00 64.42  ? 207 ASP A H    1 
ATOM   3120 H HA   . ASP A 1 207 ? -44.899 0.633  -2.475  1.00 71.49  ? 207 ASP A HA   1 
ATOM   3121 H HB2  . ASP A 1 207 ? -45.946 -1.028 -0.442  1.00 95.90  ? 207 ASP A HB2  1 
ATOM   3122 H HB3  . ASP A 1 207 ? -45.795 -1.494 -1.954  1.00 95.90  ? 207 ASP A HB3  1 
ATOM   3123 N N    . LEU A 1 208 ? -47.810 1.129  -1.209  1.00 46.66  ? 208 LEU A N    1 
ATOM   3124 C CA   . LEU A 1 208 ? -49.145 1.540  -1.626  1.00 52.50  ? 208 LEU A CA   1 
ATOM   3125 C C    . LEU A 1 208 ? -49.087 2.847  -2.414  1.00 49.04  ? 208 LEU A C    1 
ATOM   3126 O O    . LEU A 1 208 ? -49.715 2.971  -3.473  1.00 47.05  ? 208 LEU A O    1 
ATOM   3127 C CB   . LEU A 1 208 ? -50.059 1.658  -0.406  1.00 54.74  ? 208 LEU A CB   1 
ATOM   3128 C CG   . LEU A 1 208 ? -50.499 0.282  0.115   1.00 54.41  ? 208 LEU A CG   1 
ATOM   3129 C CD1  . LEU A 1 208 ? -50.697 0.392  1.609   1.00 55.55  ? 208 LEU A CD1  1 
ATOM   3130 C CD2  . LEU A 1 208 ? -51.718 -0.197 -0.645  1.00 48.77  ? 208 LEU A CD2  1 
ATOM   3131 H H    . LEU A 1 208 ? -47.684 1.057  -0.362  1.00 56.04  ? 208 LEU A H    1 
ATOM   3132 H HA   . LEU A 1 208 ? -49.527 0.864  -2.206  1.00 63.05  ? 208 LEU A HA   1 
ATOM   3133 H HB2  . LEU A 1 208 ? -49.584 2.115  0.305   1.00 65.74  ? 208 LEU A HB2  1 
ATOM   3134 H HB3  . LEU A 1 208 ? -50.853 2.159  -0.651  1.00 65.74  ? 208 LEU A HB3  1 
ATOM   3135 H HG   . LEU A 1 208 ? -49.830 -0.404 -0.034  1.00 65.34  ? 208 LEU A HG   1 
ATOM   3136 H HD11 . LEU A 1 208 ? -50.906 -0.486 1.966   1.00 66.72  ? 208 LEU A HD11 1 
ATOM   3137 H HD12 . LEU A 1 208 ? -51.429 1.003  1.787   1.00 66.72  ? 208 LEU A HD12 1 
ATOM   3138 H HD13 . LEU A 1 208 ? -49.881 0.727  2.012   1.00 66.72  ? 208 LEU A HD13 1 
ATOM   3139 H HD21 . LEU A 1 208 ? -52.336 0.544  -0.750  1.00 58.57  ? 208 LEU A HD21 1 
ATOM   3140 H HD22 . LEU A 1 208 ? -52.141 -0.912 -0.145  1.00 58.57  ? 208 LEU A HD22 1 
ATOM   3141 H HD23 . LEU A 1 208 ? -51.440 -0.521 -1.515  1.00 58.57  ? 208 LEU A HD23 1 
ATOM   3142 N N    . PHE A 1 209 ? -48.307 3.820  -1.937  1.00 48.55  ? 209 PHE A N    1 
ATOM   3143 C CA   . PHE A 1 209 ? -48.192 5.086  -2.655  1.00 48.74  ? 209 PHE A CA   1 
ATOM   3144 C C    . PHE A 1 209 ? -47.662 4.857  -4.065  1.00 46.84  ? 209 PHE A C    1 
ATOM   3145 O O    . PHE A 1 209 ? -48.272 5.282  -5.051  1.00 45.73  ? 209 PHE A O    1 
ATOM   3146 C CB   . PHE A 1 209 ? -47.273 6.036  -1.876  1.00 48.25  ? 209 PHE A CB   1 
ATOM   3147 C CG   . PHE A 1 209 ? -47.186 7.411  -2.458  1.00 52.61  ? 209 PHE A CG   1 
ATOM   3148 C CD1  . PHE A 1 209 ? -48.255 8.302  -2.346  1.00 52.19  ? 209 PHE A CD1  1 
ATOM   3149 C CD2  . PHE A 1 209 ? -46.034 7.823  -3.101  1.00 51.69  ? 209 PHE A CD2  1 
ATOM   3150 C CE1  . PHE A 1 209 ? -48.187 9.558  -2.892  1.00 52.07  ? 209 PHE A CE1  1 
ATOM   3151 C CE2  . PHE A 1 209 ? -45.957 9.095  -3.628  1.00 55.82  ? 209 PHE A CE2  1 
ATOM   3152 C CZ   . PHE A 1 209 ? -47.044 9.961  -3.522  1.00 50.38  ? 209 PHE A CZ   1 
ATOM   3153 H H    . PHE A 1 209 ? -47.844 3.772  -1.214  1.00 58.31  ? 209 PHE A H    1 
ATOM   3154 H HA   . PHE A 1 209 ? -49.066 5.501  -2.724  1.00 58.54  ? 209 PHE A HA   1 
ATOM   3155 H HB2  . PHE A 1 209 ? -47.609 6.120  -0.970  1.00 57.95  ? 209 PHE A HB2  1 
ATOM   3156 H HB3  . PHE A 1 209 ? -46.378 5.663  -1.864  1.00 57.95  ? 209 PHE A HB3  1 
ATOM   3157 H HD1  . PHE A 1 209 ? -49.025 8.039  -1.895  1.00 62.68  ? 209 PHE A HD1  1 
ATOM   3158 H HD2  . PHE A 1 209 ? -45.312 7.243  -3.179  1.00 62.08  ? 209 PHE A HD2  1 
ATOM   3159 H HE1  . PHE A 1 209 ? -48.915 10.133 -2.833  1.00 62.53  ? 209 PHE A HE1  1 
ATOM   3160 H HE2  . PHE A 1 209 ? -45.180 9.375  -4.053  1.00 67.04  ? 209 PHE A HE2  1 
ATOM   3161 H HZ   . PHE A 1 209 ? -46.991 10.817 -3.883  1.00 60.50  ? 209 PHE A HZ   1 
ATOM   3162 N N    . MET A 1 210 ? -46.525 4.172  -4.180  1.00 45.72  ? 210 MET A N    1 
ATOM   3163 C CA   . MET A 1 210 ? -45.928 3.989  -5.494  1.00 47.45  ? 210 MET A CA   1 
ATOM   3164 C C    . MET A 1 210 ? -46.853 3.224  -6.429  1.00 49.77  ? 210 MET A C    1 
ATOM   3165 O O    . MET A 1 210 ? -46.929 3.541  -7.622  1.00 45.83  ? 210 MET A O    1 
ATOM   3166 C CB   . MET A 1 210 ? -44.574 3.278  -5.366  1.00 48.47  ? 210 MET A CB   1 
ATOM   3167 C CG   . MET A 1 210 ? -43.427 4.159  -4.846  1.00 46.28  ? 210 MET A CG   1 
ATOM   3168 S SD   . MET A 1 210 ? -43.298 5.818  -5.609  1.00 49.93  ? 210 MET A SD   1 
ATOM   3169 C CE   . MET A 1 210 ? -43.693 5.473  -7.331  1.00 54.26  ? 210 MET A CE   1 
ATOM   3170 H H    . MET A 1 210 ? -46.092 3.815  -3.529  1.00 54.92  ? 210 MET A H    1 
ATOM   3171 H HA   . MET A 1 210 ? -45.764 4.864  -5.878  1.00 56.99  ? 210 MET A HA   1 
ATOM   3172 H HB2  . MET A 1 210 ? -44.674 2.536  -4.749  1.00 58.22  ? 210 MET A HB2  1 
ATOM   3173 H HB3  . MET A 1 210 ? -44.315 2.950  -6.241  1.00 58.22  ? 210 MET A HB3  1 
ATOM   3174 H HG2  . MET A 1 210 ? -43.550 4.289  -3.892  1.00 55.58  ? 210 MET A HG2  1 
ATOM   3175 H HG3  . MET A 1 210 ? -42.590 3.699  -5.012  1.00 55.58  ? 210 MET A HG3  1 
ATOM   3176 H HE1  . MET A 1 210 ? -42.973 4.953  -7.722  1.00 65.17  ? 210 MET A HE1  1 
ATOM   3177 H HE2  . MET A 1 210 ? -43.792 6.312  -7.807  1.00 65.17  ? 210 MET A HE2  1 
ATOM   3178 H HE3  . MET A 1 210 ? -44.522 4.971  -7.370  1.00 65.17  ? 210 MET A HE3  1 
ATOM   3179 N N    . SER A 1 211 ? -47.581 2.222  -5.913  1.00 48.40  ? 211 SER A N    1 
ATOM   3180 C CA   . SER A 1 211 ? -48.549 1.532  -6.761  1.00 46.27  ? 211 SER A CA   1 
ATOM   3181 C C    . SER A 1 211 ? -49.571 2.514  -7.297  1.00 47.94  ? 211 SER A C    1 
ATOM   3182 O O    . SER A 1 211 ? -49.866 2.540  -8.497  1.00 45.06  ? 211 SER A O    1 
ATOM   3183 C CB   . SER A 1 211 ? -49.263 0.403  -6.010  1.00 55.62  ? 211 SER A CB   1 
ATOM   3184 O OG   . SER A 1 211 ? -48.449 -0.724 -5.813  1.00 74.66  ? 211 SER A OG   1 
ATOM   3185 H H    . SER A 1 211 ? -47.532 1.936  -5.103  1.00 58.13  ? 211 SER A H    1 
ATOM   3186 H HA   . SER A 1 211 ? -48.062 1.126  -7.495  1.00 55.58  ? 211 SER A HA   1 
ATOM   3187 H HB2  . SER A 1 211 ? -49.540 0.738  -5.142  1.00 66.79  ? 211 SER A HB2  1 
ATOM   3188 H HB3  . SER A 1 211 ? -50.040 0.135  -6.525  1.00 66.79  ? 211 SER A HB3  1 
ATOM   3189 H HG   . SER A 1 211 ? -48.925 -1.408 -5.711  1.00 89.64  ? 211 SER A HG   1 
ATOM   3190 N N    . HIS A 1 212 ? -50.128 3.344  -6.422  1.00 50.16  ? 212 HIS A N    1 
ATOM   3191 C CA   . HIS A 1 212 ? -51.078 4.332  -6.913  1.00 44.42  ? 212 HIS A CA   1 
ATOM   3192 C C    . HIS A 1 212 ? -50.445 5.236  -7.971  1.00 49.64  ? 212 HIS A C    1 
ATOM   3193 O O    . HIS A 1 212 ? -50.997 5.444  -9.054  1.00 48.98  ? 212 HIS A O    1 
ATOM   3194 C CB   . HIS A 1 212 ? -51.607 5.195  -5.788  1.00 47.35  ? 212 HIS A CB   1 
ATOM   3195 C CG   . HIS A 1 212 ? -52.476 6.303  -6.286  1.00 50.68  ? 212 HIS A CG   1 
ATOM   3196 N ND1  . HIS A 1 212 ? -53.778 6.091  -6.678  1.00 51.95  ? 212 HIS A ND1  1 
ATOM   3197 C CD2  . HIS A 1 212 ? -52.224 7.612  -6.520  1.00 51.39  ? 212 HIS A CD2  1 
ATOM   3198 C CE1  . HIS A 1 212 ? -54.305 7.226  -7.094  1.00 56.16  ? 212 HIS A CE1  1 
ATOM   3199 N NE2  . HIS A 1 212 ? -53.386 8.168  -7.000  1.00 50.14  ? 212 HIS A NE2  1 
ATOM   3200 H H    . HIS A 1 212 ? -49.979 3.355  -5.575  1.00 60.24  ? 212 HIS A H    1 
ATOM   3201 H HA   . HIS A 1 212 ? -51.819 3.843  -7.302  1.00 53.35  ? 212 HIS A HA   1 
ATOM   3202 H HB2  . HIS A 1 212 ? -52.132 4.645  -5.186  1.00 56.87  ? 212 HIS A HB2  1 
ATOM   3203 H HB3  . HIS A 1 212 ? -50.859 5.588  -5.311  1.00 56.87  ? 212 HIS A HB3  1 
ATOM   3204 H HD2  . HIS A 1 212 ? -51.417 8.053  -6.381  1.00 61.71  ? 212 HIS A HD2  1 
ATOM   3205 H HE1  . HIS A 1 212 ? -55.175 7.342  -7.401  1.00 67.44  ? 212 HIS A HE1  1 
ATOM   3206 H HE2  . HIS A 1 212 ? -53.495 8.996  -7.206  1.00 60.22  ? 212 HIS A HE2  1 
ATOM   3207 N N    . VAL A 1 213 ? -49.290 5.809  -7.656  1.00 45.00  ? 213 VAL A N    1 
ATOM   3208 C CA   . VAL A 1 213 ? -48.661 6.741  -8.595  1.00 56.73  ? 213 VAL A CA   1 
ATOM   3209 C C    . VAL A 1 213 ? -48.390 6.057  -9.942  1.00 54.63  ? 213 VAL A C    1 
ATOM   3210 O O    . VAL A 1 213 ? -48.644 6.631  -11.017 1.00 50.85  ? 213 VAL A O    1 
ATOM   3211 C CB   . VAL A 1 213 ? -47.381 7.319  -7.964  1.00 50.22  ? 213 VAL A CB   1 
ATOM   3212 C CG1  . VAL A 1 213 ? -46.452 7.864  -9.036  1.00 59.58  ? 213 VAL A CG1  1 
ATOM   3213 C CG2  . VAL A 1 213 ? -47.746 8.387  -6.917  1.00 50.66  ? 213 VAL A CG2  1 
ATOM   3214 H H    . VAL A 1 213 ? -48.856 5.681  -6.924  1.00 54.05  ? 213 VAL A H    1 
ATOM   3215 H HA   . VAL A 1 213 ? -49.271 7.475  -8.771  1.00 68.13  ? 213 VAL A HA   1 
ATOM   3216 H HB   . VAL A 1 213 ? -46.897 6.614  -7.506  1.00 60.32  ? 213 VAL A HB   1 
ATOM   3217 H HG11 . VAL A 1 213 ? -45.795 8.444  -8.620  1.00 71.54  ? 213 VAL A HG11 1 
ATOM   3218 H HG12 . VAL A 1 213 ? -46.008 7.123  -9.476  1.00 71.54  ? 213 VAL A HG12 1 
ATOM   3219 H HG13 . VAL A 1 213 ? -46.975 8.366  -9.681  1.00 71.54  ? 213 VAL A HG13 1 
ATOM   3220 H HG21 . VAL A 1 213 ? -48.327 9.047  -7.327  1.00 60.84  ? 213 VAL A HG21 1 
ATOM   3221 H HG22 . VAL A 1 213 ? -46.932 8.813  -6.603  1.00 60.84  ? 213 VAL A HG22 1 
ATOM   3222 H HG23 . VAL A 1 213 ? -48.202 7.960  -6.175  1.00 60.84  ? 213 VAL A HG23 1 
ATOM   3223 N N    . LYS A 1 214 ? -47.883 4.815  -9.910  1.00 55.66  ? 214 LYS A N    1 
ATOM   3224 C CA   . LYS A 1 214 ? -47.514 4.130  -11.142 1.00 53.80  ? 214 LYS A CA   1 
ATOM   3225 C C    . LYS A 1 214 ? -48.726 3.766  -11.964 1.00 51.54  ? 214 LYS A C    1 
ATOM   3226 O O    . LYS A 1 214 ? -48.641 3.745  -13.191 1.00 59.07  ? 214 LYS A O    1 
ATOM   3227 C CB   . LYS A 1 214 ? -46.694 2.880  -10.829 1.00 57.50  ? 214 LYS A CB   1 
ATOM   3228 C CG   . LYS A 1 214 ? -45.199 3.187  -10.707 1.00 60.83  ? 214 LYS A CG   1 
ATOM   3229 C CD   . LYS A 1 214 ? -44.409 2.040  -10.044 1.00 86.57  ? 214 LYS A CD   1 
ATOM   3230 C CE   . LYS A 1 214 ? -43.248 2.572  -9.158  1.00 68.83  ? 214 LYS A CE   1 
ATOM   3231 N NZ   . LYS A 1 214 ? -42.365 1.501  -8.580  1.00 68.41  ? 214 LYS A NZ   1 
ATOM   3232 H H    . LYS A 1 214 ? -47.747 4.358  -9.194  1.00 66.85  ? 214 LYS A H    1 
ATOM   3233 H HA   . LYS A 1 214 ? -46.960 4.726  -11.670 1.00 64.61  ? 214 LYS A HA   1 
ATOM   3234 H HB2  . LYS A 1 214 ? -46.996 2.504  -9.988  1.00 69.05  ? 214 LYS A HB2  1 
ATOM   3235 H HB3  . LYS A 1 214 ? -46.814 2.235  -11.543 1.00 69.05  ? 214 LYS A HB3  1 
ATOM   3236 H HG2  . LYS A 1 214 ? -44.832 3.330  -11.593 1.00 73.04  ? 214 LYS A HG2  1 
ATOM   3237 H HG3  . LYS A 1 214 ? -45.083 3.983  -10.166 1.00 73.04  ? 214 LYS A HG3  1 
ATOM   3238 H HD2  . LYS A 1 214 ? -45.007 1.523  -9.481  1.00 103.94 ? 214 LYS A HD2  1 
ATOM   3239 H HD3  . LYS A 1 214 ? -44.029 1.473  -10.733 1.00 103.94 ? 214 LYS A HD3  1 
ATOM   3240 H HE2  . LYS A 1 214 ? -42.689 3.153  -9.697  1.00 82.65  ? 214 LYS A HE2  1 
ATOM   3241 H HE3  . LYS A 1 214 ? -43.627 3.071  -8.417  1.00 82.65  ? 214 LYS A HE3  1 
ATOM   3242 H HZ1  . LYS A 1 214 ? -41.720 1.869  -8.090  1.00 82.14  ? 214 LYS A HZ1  1 
ATOM   3243 H HZ2  . LYS A 1 214 ? -42.845 0.956  -8.064  1.00 82.14  ? 214 LYS A HZ2  1 
ATOM   3244 H HZ3  . LYS A 1 214 ? -41.995 1.025  -9.235  1.00 82.14  ? 214 LYS A HZ3  1 
ATOM   3245 N N    . SER A 1 215 ? -49.866 3.490  -11.333 1.00 55.60  ? 215 SER A N    1 
ATOM   3246 C CA   . SER A 1 215 ? -51.036 3.215  -12.147 1.00 57.61  ? 215 SER A CA   1 
ATOM   3247 C C    . SER A 1 215 ? -51.526 4.448  -12.881 1.00 55.99  ? 215 SER A C    1 
ATOM   3248 O O    . SER A 1 215 ? -52.354 4.313  -13.792 1.00 58.10  ? 215 SER A O    1 
ATOM   3249 C CB   . SER A 1 215 ? -52.185 2.677  -11.296 1.00 64.78  ? 215 SER A CB   1 
ATOM   3250 O OG   . SER A 1 215 ? -52.799 3.715  -10.550 1.00 65.91  ? 215 SER A OG   1 
ATOM   3251 H H    . SER A 1 215 ? -49.977 3.458  -10.480 1.00 66.77  ? 215 SER A H    1 
ATOM   3252 H HA   . SER A 1 215 ? -50.794 2.530  -12.789 1.00 69.18  ? 215 SER A HA   1 
ATOM   3253 H HB2  . SER A 1 215 ? -52.847 2.275  -11.879 1.00 77.78  ? 215 SER A HB2  1 
ATOM   3254 H HB3  . SER A 1 215 ? -51.837 2.012  -10.682 1.00 77.78  ? 215 SER A HB3  1 
ATOM   3255 H HG   . SER A 1 215 ? -53.634 3.626  -10.568 1.00 79.14  ? 215 SER A HG   1 
ATOM   3256 N N    . VAL A 1 216 ? -51.021 5.630  -12.525 1.00 55.77  ? 216 VAL A N    1 
ATOM   3257 C CA   . VAL A 1 216 ? -51.464 6.899  -13.114 1.00 53.12  ? 216 VAL A CA   1 
ATOM   3258 C C    . VAL A 1 216 ? -50.496 7.345  -14.192 1.00 54.35  ? 216 VAL A C    1 
ATOM   3259 O O    . VAL A 1 216 ? -50.897 7.628  -15.322 1.00 52.38  ? 216 VAL A O    1 
ATOM   3260 C CB   . VAL A 1 216 ? -51.572 7.992  -12.034 1.00 56.92  ? 216 VAL A CB   1 
ATOM   3261 C CG1  . VAL A 1 216 ? -52.094 9.264  -12.643 1.00 55.59  ? 216 VAL A CG1  1 
ATOM   3262 C CG2  . VAL A 1 216 ? -52.463 7.560  -10.877 1.00 59.31  ? 216 VAL A CG2  1 
ATOM   3263 H H    . VAL A 1 216 ? -50.406 5.728  -11.931 1.00 66.97  ? 216 VAL A H    1 
ATOM   3264 H HA   . VAL A 1 216 ? -52.331 6.753  -13.524 1.00 63.80  ? 216 VAL A HA   1 
ATOM   3265 H HB   . VAL A 1 216 ? -50.686 8.149  -11.673 1.00 68.36  ? 216 VAL A HB   1 
ATOM   3266 H HG11 . VAL A 1 216 ? -51.445 9.598  -13.282 1.00 66.76  ? 216 VAL A HG11 1 
ATOM   3267 H HG12 . VAL A 1 216 ? -52.232 9.917  -11.940 1.00 66.76  ? 216 VAL A HG12 1 
ATOM   3268 H HG13 . VAL A 1 216 ? -52.934 9.078  -13.092 1.00 66.76  ? 216 VAL A HG13 1 
ATOM   3269 H HG21 . VAL A 1 216 ? -52.494 8.273  -10.220 1.00 71.23  ? 216 VAL A HG21 1 
ATOM   3270 H HG22 . VAL A 1 216 ? -53.354 7.381  -11.214 1.00 71.23  ? 216 VAL A HG22 1 
ATOM   3271 H HG23 . VAL A 1 216 ? -52.093 6.757  -10.477 1.00 71.23  ? 216 VAL A HG23 1 
ATOM   3272 N N    . THR A 1 217 ? -49.211 7.454  -13.825 1.00 59.29  ? 217 THR A N    1 
ATOM   3273 C CA   . THR A 1 217 ? -48.169 7.778  -14.789 1.00 54.90  ? 217 THR A CA   1 
ATOM   3274 C C    . THR A 1 217 ? -47.910 6.623  -15.742 1.00 61.07  ? 217 THR A C    1 
ATOM   3275 O O    . THR A 1 217 ? -47.420 6.853  -16.854 1.00 63.50  ? 217 THR A O    1 
ATOM   3276 C CB   . THR A 1 217 ? -46.886 8.158  -14.046 1.00 55.78  ? 217 THR A CB   1 
ATOM   3277 O OG1  . THR A 1 217 ? -46.330 6.995  -13.404 1.00 55.09  ? 217 THR A OG1  1 
ATOM   3278 C CG2  . THR A 1 217 ? -47.218 9.209  -12.983 1.00 50.99  ? 217 THR A CG2  1 
ATOM   3279 H H    . THR A 1 217 ? -48.923 7.344  -13.022 1.00 71.19  ? 217 THR A H    1 
ATOM   3280 H HA   . THR A 1 217 ? -48.440 8.544  -15.320 1.00 65.93  ? 217 THR A HA   1 
ATOM   3281 H HB   . THR A 1 217 ? -46.233 8.517  -14.666 1.00 66.99  ? 217 THR A HB   1 
ATOM   3282 H HG1  . THR A 1 217 ? -46.794 6.786  -12.736 1.00 66.16  ? 217 THR A HG1  1 
ATOM   3283 H HG21 . THR A 1 217 ? -47.692 8.796  -12.245 1.00 61.24  ? 217 THR A HG21 1 
ATOM   3284 H HG22 . THR A 1 217 ? -46.401 9.610  -12.648 1.00 61.24  ? 217 THR A HG22 1 
ATOM   3285 H HG23 . THR A 1 217 ? -47.776 9.903  -13.367 1.00 61.24  ? 217 THR A HG23 1 
ATOM   3286 N N    . LYS A 1 218 ? -48.259 5.397  -15.334 1.00 59.86  ? 218 LYS A N    1 
ATOM   3287 C CA   . LYS A 1 218 ? -48.067 4.193  -16.142 1.00 61.29  ? 218 LYS A CA   1 
ATOM   3288 C C    . LYS A 1 218 ? -46.601 4.023  -16.526 1.00 65.08  ? 218 LYS A C    1 
ATOM   3289 O O    . LYS A 1 218 ? -46.255 3.580  -17.624 1.00 62.67  ? 218 LYS A O    1 
ATOM   3290 C CB   . LYS A 1 218 ? -49.012 4.198  -17.351 1.00 66.71  ? 218 LYS A CB   1 
ATOM   3291 C CG   . LYS A 1 218 ? -50.472 4.006  -16.856 1.00 66.65  ? 218 LYS A CG   1 
ATOM   3292 C CD   . LYS A 1 218 ? -51.553 3.913  -17.906 1.00 64.30  ? 218 LYS A CD   1 
ATOM   3293 C CE   . LYS A 1 218 ? -52.928 3.871  -17.229 1.00 73.63  ? 218 LYS A CE   1 
ATOM   3294 N NZ   . LYS A 1 218 ? -52.968 2.990  -16.011 1.00 104.09 ? 218 LYS A NZ   1 
ATOM   3295 H H    . LYS A 1 218 ? -48.620 5.235  -14.571 1.00 71.89  ? 218 LYS A H    1 
ATOM   3296 H HA   . LYS A 1 218 ? -48.293 3.407  -15.620 1.00 73.60  ? 218 LYS A HA   1 
ATOM   3297 H HB2  . LYS A 1 218 ? -48.946 5.046  -17.817 1.00 80.10  ? 218 LYS A HB2  1 
ATOM   3298 H HB3  . LYS A 1 218 ? -48.784 3.471  -17.951 1.00 80.10  ? 218 LYS A HB3  1 
ATOM   3299 H HG2  . LYS A 1 218 ? -50.507 3.183  -16.344 1.00 80.03  ? 218 LYS A HG2  1 
ATOM   3300 H HG3  . LYS A 1 218 ? -50.696 4.760  -16.288 1.00 80.03  ? 218 LYS A HG3  1 
ATOM   3301 H HD2  . LYS A 1 218 ? -51.515 4.690  -18.486 1.00 77.21  ? 218 LYS A HD2  1 
ATOM   3302 H HD3  . LYS A 1 218 ? -51.436 3.103  -18.427 1.00 77.21  ? 218 LYS A HD3  1 
ATOM   3303 H HE2  . LYS A 1 218 ? -53.170 4.769  -16.954 1.00 88.41  ? 218 LYS A HE2  1 
ATOM   3304 H HE3  . LYS A 1 218 ? -53.579 3.531  -17.863 1.00 88.41  ? 218 LYS A HE3  1 
ATOM   3305 H HZ1  . LYS A 1 218 ? -52.421 2.296  -16.120 1.00 124.96 ? 218 LYS A HZ1  1 
ATOM   3306 H HZ2  . LYS A 1 218 ? -53.795 2.689  -15.880 1.00 124.96 ? 218 LYS A HZ2  1 
ATOM   3307 H HZ3  . LYS A 1 218 ? -52.711 3.450  -15.294 1.00 124.96 ? 218 LYS A HZ3  1 
ATOM   3308 N N    . SER A 1 219 ? -45.731 4.344  -15.576 1.00 62.23  ? 219 SER A N    1 
ATOM   3309 C CA   . SER A 1 219 ? -44.311 4.069  -15.700 1.00 60.02  ? 219 SER A CA   1 
ATOM   3310 C C    . SER A 1 219 ? -43.762 3.861  -14.300 1.00 58.98  ? 219 SER A C    1 
ATOM   3311 O O    . SER A 1 219 ? -44.227 4.487  -13.349 1.00 61.37  ? 219 SER A O    1 
ATOM   3312 C CB   . SER A 1 219 ? -43.589 5.217  -16.416 1.00 66.89  ? 219 SER A CB   1 
ATOM   3313 O OG   . SER A 1 219 ? -42.266 4.839  -16.765 1.00 70.87  ? 219 SER A OG   1 
ATOM   3314 H H    . SER A 1 219 ? -45.944 4.728  -14.837 1.00 74.73  ? 219 SER A H    1 
ATOM   3315 H HA   . SER A 1 219 ? -44.153 3.261  -16.213 1.00 72.08  ? 219 SER A HA   1 
ATOM   3316 H HB2  . SER A 1 219 ? -44.077 5.442  -17.223 1.00 80.32  ? 219 SER A HB2  1 
ATOM   3317 H HB3  . SER A 1 219 ? -43.553 5.985  -15.825 1.00 80.32  ? 219 SER A HB3  1 
ATOM   3318 H HG   . SER A 1 219 ? -41.792 4.783  -16.074 1.00 85.10  ? 219 SER A HG   1 
ATOM   3319 N N    . SER A 1 220 ? -42.786 2.973  -14.185 1.00 60.72  ? 220 SER A N    1 
ATOM   3320 C CA   . SER A 1 220 ? -42.068 2.674  -12.963 1.00 57.47  ? 220 SER A CA   1 
ATOM   3321 C C    . SER A 1 220 ? -40.775 3.522  -12.783 1.00 60.15  ? 220 SER A C    1 
ATOM   3322 O O    . SER A 1 220 ? -40.227 3.565  -11.672 1.00 55.97  ? 220 SER A O    1 
ATOM   3323 C CB   . SER A 1 220 ? -41.859 1.147  -13.014 1.00 72.63  ? 220 SER A CB   1 
ATOM   3324 O OG   . SER A 1 220 ? -41.270 0.736  -14.258 1.00 83.94  ? 220 SER A OG   1 
ATOM   3325 H H    . SER A 1 220 ? -42.505 2.501  -14.846 1.00 72.92  ? 220 SER A H    1 
ATOM   3326 H HA   . SER A 1 220 ? -42.547 2.886  -12.146 1.00 69.02  ? 220 SER A HA   1 
ATOM   3327 H HB2  . SER A 1 220 ? -41.271 0.887  -12.288 1.00 87.21  ? 220 SER A HB2  1 
ATOM   3328 H HB3  . SER A 1 220 ? -42.720 0.711  -12.916 1.00 87.21  ? 220 SER A HB3  1 
ATOM   3329 H HG   . SER A 1 220 ? -41.582 -0.009 -14.491 1.00 100.78 ? 220 SER A HG   1 
ATOM   3330 N N    . SER A 1 221 ? -40.406 4.359  -13.751 1.00 55.28  ? 221 SER A N    1 
ATOM   3331 C CA   . SER A 1 221 ? -39.328 5.313  -13.578 1.00 55.64  ? 221 SER A CA   1 
ATOM   3332 C C    . SER A 1 221 ? -39.826 6.734  -13.816 1.00 47.10  ? 221 SER A C    1 
ATOM   3333 O O    . SER A 1 221 ? -40.832 6.968  -14.487 1.00 52.35  ? 221 SER A O    1 
ATOM   3334 C CB   . SER A 1 221 ? -38.220 5.026  -14.551 1.00 56.67  ? 221 SER A CB   1 
ATOM   3335 O OG   . SER A 1 221 ? -38.750 5.313  -15.830 1.00 54.00  ? 221 SER A OG   1 
ATOM   3336 H H    . SER A 1 221 ? -40.775 4.389  -14.528 1.00 66.39  ? 221 SER A H    1 
ATOM   3337 H HA   . SER A 1 221 ? -38.996 5.255  -12.668 1.00 66.82  ? 221 SER A HA   1 
ATOM   3338 H HB2  . SER A 1 221 ? -37.456 5.595  -14.369 1.00 68.05  ? 221 SER A HB2  1 
ATOM   3339 H HB3  . SER A 1 221 ? -37.959 4.093  -14.498 1.00 68.05  ? 221 SER A HB3  1 
ATOM   3340 H HG   . SER A 1 221 ? -38.216 5.060  -16.427 1.00 64.85  ? 221 SER A HG   1 
ATOM   3341 N N    . TRP A 1 222 ? -39.066 7.687  -13.305 1.00 48.36  ? 222 TRP A N    1 
ATOM   3342 C CA   . TRP A 1 222 ? -39.445 9.095  -13.393 1.00 46.06  ? 222 TRP A CA   1 
ATOM   3343 C C    . TRP A 1 222 ? -39.364 9.625  -14.821 1.00 47.67  ? 222 TRP A C    1 
ATOM   3344 O O    . TRP A 1 222 ? -38.363 9.424  -15.511 1.00 52.16  ? 222 TRP A O    1 
ATOM   3345 C CB   . TRP A 1 222 ? -38.526 9.924  -12.499 1.00 43.97  ? 222 TRP A CB   1 
ATOM   3346 C CG   . TRP A 1 222 ? -38.913 11.343 -12.545 1.00 51.99  ? 222 TRP A CG   1 
ATOM   3347 C CD1  . TRP A 1 222 ? -38.302 12.369 -13.232 1.00 45.99  ? 222 TRP A CD1  1 
ATOM   3348 C CD2  . TRP A 1 222 ? -40.057 11.900 -11.917 1.00 52.45  ? 222 TRP A CD2  1 
ATOM   3349 N NE1  . TRP A 1 222 ? -39.016 13.534 -13.066 1.00 46.51  ? 222 TRP A NE1  1 
ATOM   3350 C CE2  . TRP A 1 222 ? -40.099 13.264 -12.257 1.00 49.63  ? 222 TRP A CE2  1 
ATOM   3351 C CE3  . TRP A 1 222 ? -41.062 11.367 -11.091 1.00 51.15  ? 222 TRP A CE3  1 
ATOM   3352 C CZ2  . TRP A 1 222 ? -41.096 14.100 -11.795 1.00 49.12  ? 222 TRP A CZ2  1 
ATOM   3353 C CZ3  . TRP A 1 222 ? -42.052 12.200 -10.634 1.00 48.37  ? 222 TRP A CZ3  1 
ATOM   3354 C CH2  . TRP A 1 222 ? -42.057 13.554 -10.975 1.00 48.63  ? 222 TRP A CH2  1 
ATOM   3355 H H    . TRP A 1 222 ? -38.320 7.550  -12.899 1.00 58.08  ? 222 TRP A H    1 
ATOM   3356 H HA   . TRP A 1 222 ? -40.365 9.186  -13.100 1.00 55.32  ? 222 TRP A HA   1 
ATOM   3357 H HB2  . TRP A 1 222 ? -38.595 9.613  -11.583 1.00 52.82  ? 222 TRP A HB2  1 
ATOM   3358 H HB3  . TRP A 1 222 ? -37.610 9.842  -12.809 1.00 52.82  ? 222 TRP A HB3  1 
ATOM   3359 H HD1  . TRP A 1 222 ? -37.524 12.286 -13.734 1.00 55.24  ? 222 TRP A HD1  1 
ATOM   3360 H HE1  . TRP A 1 222 ? -38.820 14.299 -13.407 1.00 55.86  ? 222 TRP A HE1  1 
ATOM   3361 H HE3  . TRP A 1 222 ? -41.057 10.466 -10.859 1.00 61.43  ? 222 TRP A HE3  1 
ATOM   3362 H HZ2  . TRP A 1 222 ? -41.118 15.000 -12.029 1.00 58.99  ? 222 TRP A HZ2  1 
ATOM   3363 H HZ3  . TRP A 1 222 ? -42.726 11.860 -10.091 1.00 58.09  ? 222 TRP A HZ3  1 
ATOM   3364 H HH2  . TRP A 1 222 ? -42.730 14.102 -10.640 1.00 58.41  ? 222 TRP A HH2  1 
ATOM   3365 N N    . LYS A 1 223 ? -40.389 10.371 -15.251 1.00 46.53  ? 223 LYS A N    1 
ATOM   3366 C CA   . LYS A 1 223 ? -40.314 11.159 -16.485 1.00 42.68  ? 223 LYS A CA   1 
ATOM   3367 C C    . LYS A 1 223 ? -40.512 12.643 -16.182 1.00 47.75  ? 223 LYS A C    1 
ATOM   3368 O O    . LYS A 1 223 ? -41.526 13.030 -15.594 1.00 45.14  ? 223 LYS A O    1 
ATOM   3369 C CB   . LYS A 1 223 ? -41.374 10.763 -17.506 1.00 48.32  ? 223 LYS A CB   1 
ATOM   3370 C CG   . LYS A 1 223 ? -41.451 9.301  -17.955 1.00 61.18  ? 223 LYS A CG   1 
ATOM   3371 C CD   . LYS A 1 223 ? -40.340 8.942  -18.893 1.00 57.30  ? 223 LYS A CD   1 
ATOM   3372 C CE   . LYS A 1 223 ? -39.454 7.940  -18.198 1.00 66.07  ? 223 LYS A CE   1 
ATOM   3373 N NZ   . LYS A 1 223 ? -38.450 7.329  -19.098 1.00 63.08  ? 223 LYS A NZ   1 
ATOM   3374 H H    . LYS A 1 223 ? -41.142 10.436 -14.841 1.00 55.89  ? 223 LYS A H    1 
ATOM   3375 H HA   . LYS A 1 223 ? -39.431 11.006 -16.856 1.00 51.26  ? 223 LYS A HA   1 
ATOM   3376 H HB2  . LYS A 1 223 ? -42.241 10.981 -17.127 1.00 58.03  ? 223 LYS A HB2  1 
ATOM   3377 H HB3  . LYS A 1 223 ? -41.221 11.289 -18.306 1.00 58.03  ? 223 LYS A HB3  1 
ATOM   3378 H HG2  . LYS A 1 223 ? -41.389 8.725  -17.177 1.00 73.46  ? 223 LYS A HG2  1 
ATOM   3379 H HG3  . LYS A 1 223 ? -42.294 9.152  -18.412 1.00 73.46  ? 223 LYS A HG3  1 
ATOM   3380 H HD2  . LYS A 1 223 ? -40.700 8.544  -19.702 1.00 68.81  ? 223 LYS A HD2  1 
ATOM   3381 H HD3  . LYS A 1 223 ? -39.820 9.730  -19.114 1.00 68.81  ? 223 LYS A HD3  1 
ATOM   3382 H HE2  . LYS A 1 223 ? -38.979 8.386  -17.480 1.00 79.34  ? 223 LYS A HE2  1 
ATOM   3383 H HE3  . LYS A 1 223 ? -40.006 7.228  -17.839 1.00 79.34  ? 223 LYS A HE3  1 
ATOM   3384 H HZ1  . LYS A 1 223 ? -38.849 7.015  -19.829 1.00 75.74  ? 223 LYS A HZ1  1 
ATOM   3385 H HZ2  . LYS A 1 223 ? -38.037 6.659  -18.683 1.00 75.74  ? 223 LYS A HZ2  1 
ATOM   3386 H HZ3  . LYS A 1 223 ? -37.846 7.937  -19.337 1.00 75.74  ? 223 LYS A HZ3  1 
ATOM   3387 N N    . ASP A 1 224 ? -39.593 13.480 -16.644 1.00 48.46  ? 224 ASP A N    1 
ATOM   3388 C CA   . ASP A 1 224 ? -39.679 14.905 -16.340 1.00 51.21  ? 224 ASP A CA   1 
ATOM   3389 C C    . ASP A 1 224 ? -40.924 15.541 -16.946 1.00 51.98  ? 224 ASP A C    1 
ATOM   3390 O O    . ASP A 1 224 ? -41.390 16.589 -16.483 1.00 48.17  ? 224 ASP A O    1 
ATOM   3391 C CB   . ASP A 1 224 ? -38.422 15.615 -16.837 1.00 42.97  ? 224 ASP A CB   1 
ATOM   3392 C CG   . ASP A 1 224 ? -38.306 17.013 -16.316 1.00 48.89  ? 224 ASP A CG   1 
ATOM   3393 O OD1  . ASP A 1 224 ? -37.983 17.176 -15.108 1.00 55.40  ? 224 ASP A OD1  1 
ATOM   3394 O OD2  . ASP A 1 224 ? -38.527 17.938 -17.133 1.00 49.44  ? 224 ASP A OD2  1 
ATOM   3395 H H    . ASP A 1 224 ? -38.918 13.254 -17.128 1.00 58.20  ? 224 ASP A H    1 
ATOM   3396 H HA   . ASP A 1 224 ? -39.727 15.024 -15.379 1.00 61.50  ? 224 ASP A HA   1 
ATOM   3397 H HB2  . ASP A 1 224 ? -37.642 15.119 -16.544 1.00 51.62  ? 224 ASP A HB2  1 
ATOM   3398 H HB3  . ASP A 1 224 ? -38.445 15.657 -17.806 1.00 51.62  ? 224 ASP A HB3  1 
ATOM   3399 N N    . VAL A 1 225 ? -41.523 14.916 -17.951 1.00 50.54  ? 225 VAL A N    1 
ATOM   3400 C CA   . VAL A 1 225 ? -42.782 15.464 -18.417 1.00 52.92  ? 225 VAL A CA   1 
ATOM   3401 C C    . VAL A 1 225 ? -43.831 15.502 -17.303 1.00 43.76  ? 225 VAL A C    1 
ATOM   3402 O O    . VAL A 1 225 ? -44.849 16.176 -17.451 1.00 44.25  ? 225 VAL A O    1 
ATOM   3403 C CB   . VAL A 1 225 ? -43.285 14.666 -19.648 1.00 53.70  ? 225 VAL A CB   1 
ATOM   3404 C CG1  . VAL A 1 225 ? -42.194 14.628 -20.737 1.00 58.72  ? 225 VAL A CG1  1 
ATOM   3405 C CG2  . VAL A 1 225 ? -43.750 13.272 -19.252 1.00 43.49  ? 225 VAL A CG2  1 
ATOM   3406 H H    . VAL A 1 225 ? -41.235 14.214 -18.356 1.00 60.70  ? 225 VAL A H    1 
ATOM   3407 H HA   . VAL A 1 225 ? -42.634 16.380 -18.700 1.00 63.55  ? 225 VAL A HA   1 
ATOM   3408 H HB   . VAL A 1 225 ? -44.060 15.114 -20.022 1.00 64.49  ? 225 VAL A HB   1 
ATOM   3409 H HG11 . VAL A 1 225 ? -42.007 15.534 -21.028 1.00 70.51  ? 225 VAL A HG11 1 
ATOM   3410 H HG12 . VAL A 1 225 ? -42.513 14.099 -21.485 1.00 70.51  ? 225 VAL A HG12 1 
ATOM   3411 H HG13 . VAL A 1 225 ? -41.392 14.227 -20.367 1.00 70.51  ? 225 VAL A HG13 1 
ATOM   3412 H HG21 . VAL A 1 225 ? -43.010 12.797 -18.840 1.00 52.24  ? 225 VAL A HG21 1 
ATOM   3413 H HG22 . VAL A 1 225 ? -44.044 12.799 -20.046 1.00 52.24  ? 225 VAL A HG22 1 
ATOM   3414 H HG23 . VAL A 1 225 ? -44.484 13.350 -18.623 1.00 52.24  ? 225 VAL A HG23 1 
ATOM   3415 N N    . ASN A 1 226 ? -43.634 14.758 -16.217 1.00 42.59  ? 226 ASN A N    1 
ATOM   3416 C CA   . ASN A 1 226 ? -44.539 14.743 -15.074 1.00 42.97  ? 226 ASN A CA   1 
ATOM   3417 C C    . ASN A 1 226 ? -44.158 15.764 -13.987 1.00 43.46  ? 226 ASN A C    1 
ATOM   3418 O O    . ASN A 1 226 ? -44.820 15.824 -12.933 1.00 41.81  ? 226 ASN A O    1 
ATOM   3419 C CB   . ASN A 1 226 ? -44.613 13.328 -14.502 1.00 45.64  ? 226 ASN A CB   1 
ATOM   3420 C CG   . ASN A 1 226 ? -45.309 12.347 -15.473 1.00 44.24  ? 226 ASN A CG   1 
ATOM   3421 O OD1  . ASN A 1 226 ? -46.286 12.681 -16.133 1.00 46.62  ? 226 ASN A OD1  1 
ATOM   3422 N ND2  . ASN A 1 226 ? -44.790 11.150 -15.570 1.00 44.23  ? 226 ASN A ND2  1 
ATOM   3423 H H    . ASN A 1 226 ? -42.958 14.236 -16.117 1.00 51.15  ? 226 ASN A H    1 
ATOM   3424 H HA   . ASN A 1 226 ? -45.430 14.984 -15.372 1.00 51.61  ? 226 ASN A HA   1 
ATOM   3425 H HB2  . ASN A 1 226 ? -43.715 13.004 -14.335 1.00 54.82  ? 226 ASN A HB2  1 
ATOM   3426 H HB3  . ASN A 1 226 ? -45.119 13.345 -13.674 1.00 54.82  ? 226 ASN A HB3  1 
ATOM   3427 H HD21 . ASN A 1 226 ? -45.142 10.570 -16.098 1.00 53.12  ? 226 ASN A HD21 1 
ATOM   3428 H HD22 . ASN A 1 226 ? -44.096 10.943 -15.106 1.00 53.12  ? 226 ASN A HD22 1 
ATOM   3429 N N    . THR A 1 227 ? -43.149 16.592 -14.238 1.00 42.47  ? 227 THR A N    1 
ATOM   3430 C CA   . THR A 1 227 ? -42.834 17.733 -13.382 1.00 44.03  ? 227 THR A CA   1 
ATOM   3431 C C    . THR A 1 227 ? -43.814 18.864 -13.697 1.00 48.51  ? 227 THR A C    1 
ATOM   3432 O O    . THR A 1 227 ? -43.493 19.851 -14.370 1.00 46.88  ? 227 THR A O    1 
ATOM   3433 C CB   . THR A 1 227 ? -41.401 18.215 -13.587 1.00 45.04  ? 227 THR A CB   1 
ATOM   3434 O OG1  . THR A 1 227 ? -40.460 17.186 -13.260 1.00 45.77  ? 227 THR A OG1  1 
ATOM   3435 C CG2  . THR A 1 227 ? -41.148 19.433 -12.690 1.00 43.09  ? 227 THR A CG2  1 
ATOM   3436 H H    . THR A 1 227 ? -42.622 16.514 -14.913 1.00 51.01  ? 227 THR A H    1 
ATOM   3437 H HA   . THR A 1 227 ? -42.940 17.449 -12.461 1.00 52.89  ? 227 THR A HA   1 
ATOM   3438 H HB   . THR A 1 227 ? -41.272 18.456 -14.518 1.00 54.10  ? 227 THR A HB   1 
ATOM   3439 H HG1  . THR A 1 227 ? -40.683 16.809 -12.544 1.00 54.97  ? 227 THR A HG1  1 
ATOM   3440 H HG21 . THR A 1 227 ? -41.475 20.237 -13.124 1.00 51.76  ? 227 THR A HG21 1 
ATOM   3441 H HG22 . THR A 1 227 ? -41.608 19.323 -11.844 1.00 51.76  ? 227 THR A HG22 1 
ATOM   3442 H HG23 . THR A 1 227 ? -40.198 19.530 -12.522 1.00 51.76  ? 227 THR A HG23 1 
ATOM   3443 N N    . VAL A 1 228 ? -45.039 18.706 -13.214 1.00 46.35  ? 228 VAL A N    1 
ATOM   3444 C CA   . VAL A 1 228 ? -46.125 19.643 -13.449 1.00 38.87  ? 228 VAL A CA   1 
ATOM   3445 C C    . VAL A 1 228 ? -46.807 19.886 -12.112 1.00 49.57  ? 228 VAL A C    1 
ATOM   3446 O O    . VAL A 1 228 ? -46.525 19.218 -11.121 1.00 43.32  ? 228 VAL A O    1 
ATOM   3447 C CB   . VAL A 1 228 ? -47.146 19.133 -14.480 1.00 44.57  ? 228 VAL A CB   1 
ATOM   3448 C CG1  . VAL A 1 228 ? -46.520 19.037 -15.874 1.00 44.13  ? 228 VAL A CG1  1 
ATOM   3449 C CG2  . VAL A 1 228 ? -47.712 17.787 -14.045 1.00 46.25  ? 228 VAL A CG2  1 
ATOM   3450 H H    . VAL A 1 228 ? -45.273 18.036 -12.729 1.00 55.66  ? 228 VAL A H    1 
ATOM   3451 H HA   . VAL A 1 228 ? -45.761 20.477 -13.785 1.00 46.69  ? 228 VAL A HA   1 
ATOM   3452 H HB   . VAL A 1 228 ? -47.877 19.768 -14.533 1.00 53.53  ? 228 VAL A HB   1 
ATOM   3453 H HG11 . VAL A 1 228 ? -46.137 19.896 -16.108 1.00 53.01  ? 228 VAL A HG11 1 
ATOM   3454 H HG12 . VAL A 1 228 ? -45.827 18.358 -15.863 1.00 53.01  ? 228 VAL A HG12 1 
ATOM   3455 H HG13 . VAL A 1 228 ? -47.209 18.796 -16.513 1.00 53.01  ? 228 VAL A HG13 1 
ATOM   3456 H HG21 . VAL A 1 228 ? -48.337 17.475 -14.717 1.00 55.55  ? 228 VAL A HG21 1 
ATOM   3457 H HG22 . VAL A 1 228 ? -46.984 17.154 -13.951 1.00 55.55  ? 228 VAL A HG22 1 
ATOM   3458 H HG23 . VAL A 1 228 ? -48.168 17.896 -13.195 1.00 55.55  ? 228 VAL A HG23 1 
ATOM   3459 N N    . GLN A 1 229 ? -47.730 20.841 -12.080 1.00 46.84  ? 229 GLN A N    1 
ATOM   3460 C CA   . GLN A 1 229 ? -48.498 20.959 -10.851 1.00 48.23  ? 229 GLN A CA   1 
ATOM   3461 C C    . GLN A 1 229 ? -49.460 19.781 -10.723 1.00 48.84  ? 229 GLN A C    1 
ATOM   3462 O O    . GLN A 1 229 ? -49.807 19.132 -11.711 1.00 46.71  ? 229 GLN A O    1 
ATOM   3463 C CB   . GLN A 1 229 ? -49.264 22.268 -10.835 1.00 51.08  ? 229 GLN A CB   1 
ATOM   3464 C CG   . GLN A 1 229 ? -48.383 23.475 -10.963 1.00 47.84  ? 229 GLN A CG   1 
ATOM   3465 C CD   . GLN A 1 229 ? -49.255 24.679 -11.163 1.00 53.75  ? 229 GLN A CD   1 
ATOM   3466 O OE1  . GLN A 1 229 ? -50.171 24.925 -10.364 1.00 49.76  ? 229 GLN A OE1  1 
ATOM   3467 N NE2  . GLN A 1 229 ? -49.012 25.418 -12.229 1.00 50.98  ? 229 GLN A NE2  1 
ATOM   3468 H H    . GLN A 1 229 ? -47.917 21.392 -12.713 1.00 56.26  ? 229 GLN A H    1 
ATOM   3469 H HA   . GLN A 1 229 ? -47.902 20.954 -10.085 1.00 57.93  ? 229 GLN A HA   1 
ATOM   3470 H HB2  . GLN A 1 229 ? -49.888 22.274 -11.578 1.00 61.35  ? 229 GLN A HB2  1 
ATOM   3471 H HB3  . GLN A 1 229 ? -49.747 22.338 -9.997  1.00 61.35  ? 229 GLN A HB3  1 
ATOM   3472 H HG2  . GLN A 1 229 ? -47.861 23.592 -10.154 1.00 57.46  ? 229 GLN A HG2  1 
ATOM   3473 H HG3  . GLN A 1 229 ? -47.795 23.377 -11.727 1.00 57.46  ? 229 GLN A HG3  1 
ATOM   3474 H HE21 . GLN A 1 229 ? -49.487 26.118 -12.385 1.00 61.22  ? 229 GLN A HE21 1 
ATOM   3475 H HE22 . GLN A 1 229 ? -48.379 25.200 -12.768 1.00 61.22  ? 229 GLN A HE22 1 
ATOM   3476 N N    . PHE A 1 230 ? -49.918 19.528 -9.495  1.00 48.92  ? 230 PHE A N    1 
ATOM   3477 C CA   . PHE A 1 230 ? -50.720 18.334 -9.233  1.00 48.98  ? 230 PHE A CA   1 
ATOM   3478 C C    . PHE A 1 230 ? -51.538 18.443 -7.946  1.00 45.20  ? 230 PHE A C    1 
ATOM   3479 O O    . PHE A 1 230 ? -51.190 19.174 -7.012  1.00 42.93  ? 230 PHE A O    1 
ATOM   3480 C CB   . PHE A 1 230 ? -49.807 17.122 -9.072  1.00 44.27  ? 230 PHE A CB   1 
ATOM   3481 C CG   . PHE A 1 230 ? -49.072 17.153 -7.758  1.00 42.81  ? 230 PHE A CG   1 
ATOM   3482 C CD1  . PHE A 1 230 ? -48.043 18.050 -7.557  1.00 43.15  ? 230 PHE A CD1  1 
ATOM   3483 C CD2  . PHE A 1 230 ? -49.481 16.362 -6.699  1.00 41.33  ? 230 PHE A CD2  1 
ATOM   3484 C CE1  . PHE A 1 230 ? -47.408 18.114 -6.328  1.00 37.83  ? 230 PHE A CE1  1 
ATOM   3485 C CE2  . PHE A 1 230 ? -48.847 16.408 -5.501  1.00 36.66  ? 230 PHE A CE2  1 
ATOM   3486 C CZ   . PHE A 1 230 ? -47.807 17.276 -5.316  1.00 36.61  ? 230 PHE A CZ   1 
ATOM   3487 H H    . PHE A 1 230 ? -49.781 20.027 -8.808  1.00 58.75  ? 230 PHE A H    1 
ATOM   3488 H HA   . PHE A 1 230 ? -51.341 18.251 -9.973  1.00 58.83  ? 230 PHE A HA   1 
ATOM   3489 H HB2  . PHE A 1 230 ? -50.341 16.312 -9.104  1.00 53.18  ? 230 PHE A HB2  1 
ATOM   3490 H HB3  . PHE A 1 230 ? -49.153 17.116 -9.788  1.00 53.18  ? 230 PHE A HB3  1 
ATOM   3491 H HD1  . PHE A 1 230 ? -47.776 18.612 -8.248  1.00 51.83  ? 230 PHE A HD1  1 
ATOM   3492 H HD2  . PHE A 1 230 ? -50.205 15.788 -6.811  1.00 49.64  ? 230 PHE A HD2  1 
ATOM   3493 H HE1  . PHE A 1 230 ? -46.716 18.719 -6.189  1.00 45.45  ? 230 PHE A HE1  1 
ATOM   3494 H HE2  . PHE A 1 230 ? -49.119 15.851 -4.808  1.00 44.04  ? 230 PHE A HE2  1 
ATOM   3495 H HZ   . PHE A 1 230 ? -47.366 17.299 -4.498  1.00 43.99  ? 230 PHE A HZ   1 
ATOM   3496 N N    . SER A 1 231 ? -52.583 17.636 -7.875  1.00 43.89  ? 231 SER A N    1 
ATOM   3497 C CA   . SER A 1 231 ? -53.287 17.413 -6.628  1.00 47.34  ? 231 SER A CA   1 
ATOM   3498 C C    . SER A 1 231 ? -53.337 15.923 -6.373  1.00 50.38  ? 231 SER A C    1 
ATOM   3499 O O    . SER A 1 231 ? -53.400 15.129 -7.317  1.00 50.12  ? 231 SER A O    1 
ATOM   3500 C CB   . SER A 1 231 ? -54.700 17.977 -6.662  1.00 53.28  ? 231 SER A CB   1 
ATOM   3501 O OG   . SER A 1 231 ? -55.515 17.305 -7.604  1.00 51.04  ? 231 SER A OG   1 
ATOM   3502 H H    . SER A 1 231 ? -52.905 17.202 -8.544  1.00 52.72  ? 231 SER A H    1 
ATOM   3503 H HA   . SER A 1 231 ? -52.818 17.849 -5.899  1.00 56.85  ? 231 SER A HA   1 
ATOM   3504 H HB2  . SER A 1 231 ? -55.096 17.879 -5.781  1.00 63.99  ? 231 SER A HB2  1 
ATOM   3505 H HB3  . SER A 1 231 ? -54.655 18.916 -6.902  1.00 63.99  ? 231 SER A HB3  1 
ATOM   3506 H HG   . SER A 1 231 ? -55.988 16.729 -7.216  1.00 61.30  ? 231 SER A HG   1 
ATOM   3507 N N    . ILE A 1 232 ? -53.346 15.546 -5.092  1.00 53.27  ? 232 ILE A N    1 
ATOM   3508 C CA   . ILE A 1 232 ? -53.231 14.140 -4.735  1.00 50.32  ? 232 ILE A CA   1 
ATOM   3509 C C    . ILE A 1 232 ? -54.256 13.669 -3.703  1.00 56.78  ? 232 ILE A C    1 
ATOM   3510 O O    . ILE A 1 232 ? -54.710 12.520 -3.770  1.00 58.05  ? 232 ILE A O    1 
ATOM   3511 C CB   . ILE A 1 232 ? -51.782 13.885 -4.277  1.00 52.52  ? 232 ILE A CB   1 
ATOM   3512 C CG1  . ILE A 1 232 ? -51.539 12.440 -3.856  1.00 53.06  ? 232 ILE A CG1  1 
ATOM   3513 C CG2  . ILE A 1 232 ? -51.398 14.783 -3.114  1.00 40.86  ? 232 ILE A CG2  1 
ATOM   3514 C CD1  . ILE A 1 232 ? -51.550 11.499 -4.990  1.00 55.73  ? 232 ILE A CD1  1 
ATOM   3515 H H    . ILE A 1 232 ? -53.418 16.083 -4.424  1.00 63.97  ? 232 ILE A H    1 
ATOM   3516 H HA   . ILE A 1 232 ? -53.456 13.608 -5.514  1.00 60.43  ? 232 ILE A HA   1 
ATOM   3517 H HB   . ILE A 1 232 ? -51.235 14.083 -5.054  1.00 63.08  ? 232 ILE A HB   1 
ATOM   3518 H HG12 . ILE A 1 232 ? -50.672 12.380 -3.425  1.00 63.73  ? 232 ILE A HG12 1 
ATOM   3519 H HG13 . ILE A 1 232 ? -52.237 12.172 -3.238  1.00 63.73  ? 232 ILE A HG13 1 
ATOM   3520 H HG21 . ILE A 1 232 ? -50.434 14.776 -3.014  1.00 49.09  ? 232 ILE A HG21 1 
ATOM   3521 H HG22 . ILE A 1 232 ? -51.818 14.449 -2.305  1.00 49.09  ? 232 ILE A HG22 1 
ATOM   3522 H HG23 . ILE A 1 232 ? -51.705 15.685 -3.297  1.00 49.09  ? 232 ILE A HG23 1 
ATOM   3523 H HD11 . ILE A 1 232 ? -51.054 11.888 -5.727  1.00 66.93  ? 232 ILE A HD11 1 
ATOM   3524 H HD12 . ILE A 1 232 ? -51.135 10.668 -4.714  1.00 66.93  ? 232 ILE A HD12 1 
ATOM   3525 H HD13 . ILE A 1 232 ? -52.468 11.338 -5.258  1.00 66.93  ? 232 ILE A HD13 1 
ATOM   3526 N N    . LEU A 1 233 ? -54.671 14.534 -2.777  1.00 53.61  ? 233 LEU A N    1 
ATOM   3527 C CA   . LEU A 1 233 ? -55.738 14.182 -1.844  1.00 58.15  ? 233 LEU A CA   1 
ATOM   3528 C C    . LEU A 1 233 ? -57.043 14.889 -2.185  1.00 60.33  ? 233 LEU A C    1 
ATOM   3529 O O    . LEU A 1 233 ? -57.048 15.967 -2.784  1.00 67.66  ? 233 LEU A O    1 
ATOM   3530 C CB   . LEU A 1 233 ? -55.384 14.537 -0.400  1.00 49.08  ? 233 LEU A CB   1 
ATOM   3531 C CG   . LEU A 1 233 ? -53.984 14.185 0.082   1.00 49.00  ? 233 LEU A CG   1 
ATOM   3532 C CD1  . LEU A 1 233 ? -53.643 14.709 1.448   1.00 42.66  ? 233 LEU A CD1  1 
ATOM   3533 C CD2  . LEU A 1 233 ? -53.873 12.650 0.042   1.00 54.47  ? 233 LEU A CD2  1 
ATOM   3534 H H    . LEU A 1 233 ? -54.350 15.325 -2.672  1.00 64.39  ? 233 LEU A H    1 
ATOM   3535 H HA   . LEU A 1 233 ? -55.869 13.224 -1.918  1.00 69.83  ? 233 LEU A HA   1 
ATOM   3536 H HB2  . LEU A 1 233 ? -55.485 15.496 -0.296  1.00 58.95  ? 233 LEU A HB2  1 
ATOM   3537 H HB3  . LEU A 1 233 ? -56.007 14.073 0.181   1.00 58.95  ? 233 LEU A HB3  1 
ATOM   3538 H HG   . LEU A 1 233 ? -53.334 14.612 -0.498  1.00 58.85  ? 233 LEU A HG   1 
ATOM   3539 H HD11 . LEU A 1 233 ? -54.062 14.145 2.117   1.00 51.24  ? 233 LEU A HD11 1 
ATOM   3540 H HD12 . LEU A 1 233 ? -52.680 14.696 1.560   1.00 51.24  ? 233 LEU A HD12 1 
ATOM   3541 H HD13 . LEU A 1 233 ? -53.973 15.618 1.529   1.00 51.24  ? 233 LEU A HD13 1 
ATOM   3542 H HD21 . LEU A 1 233 ? -54.629 12.266 0.514   1.00 65.42  ? 233 LEU A HD21 1 
ATOM   3543 H HD22 . LEU A 1 233 ? -53.878 12.357 -0.883  1.00 65.42  ? 233 LEU A HD22 1 
ATOM   3544 H HD23 . LEU A 1 233 ? -53.045 12.382 0.469   1.00 65.42  ? 233 LEU A HD23 1 
ATOM   3545 N N    . ASN A 1 234 ? -58.152 14.275 -1.766  1.00 66.96  ? 234 ASN A N    1 
ATOM   3546 C CA   . ASN A 1 234 ? -59.488 14.856 -1.918  1.00 65.93  ? 234 ASN A CA   1 
ATOM   3547 C C    . ASN A 1 234 ? -59.988 15.431 -0.595  1.00 66.79  ? 234 ASN A C    1 
ATOM   3548 O O    . ASN A 1 234 ? -60.184 16.646 -0.446  1.00 64.61  ? 234 ASN A O    1 
ATOM   3549 C CB   . ASN A 1 234 ? -60.492 13.801 -2.386  1.00 67.15  ? 234 ASN A CB   1 
ATOM   3550 C CG   . ASN A 1 234 ? -60.017 13.035 -3.585  1.00 73.18  ? 234 ASN A CG   1 
ATOM   3551 O OD1  . ASN A 1 234 ? -59.778 13.630 -4.630  1.00 75.80  ? 234 ASN A OD1  1 
ATOM   3552 N ND2  . ASN A 1 234 ? -59.864 11.704 -3.449  1.00 71.19  ? 234 ASN A ND2  1 
ATOM   3553 H H    . ASN A 1 234 ? -58.158 13.506 -1.382  1.00 80.40  ? 234 ASN A H    1 
ATOM   3554 H HA   . ASN A 1 234 ? -59.430 15.562 -2.580  1.00 79.17  ? 234 ASN A HA   1 
ATOM   3555 H HB2  . ASN A 1 234 ? -60.643 13.168 -1.667  1.00 80.63  ? 234 ASN A HB2  1 
ATOM   3556 H HB3  . ASN A 1 234 ? -61.325 14.240 -2.621  1.00 80.63  ? 234 ASN A HB3  1 
ATOM   3557 H HD21 . ASN A 1 234 ? -60.037 11.326 -2.696  1.00 85.48  ? 234 ASN A HD21 1 
ATOM   3558 H HD22 . ASN A 1 234 ? -59.593 11.232 -4.115  1.00 85.48  ? 234 ASN A HD22 1 
ATOM   3559 N N    . ASP A 1 235 ? -60.224 14.573 0.349   1.00 64.98  ? 235 ASP A N    1 
ATOM   3560 C CA   . ASP A 1 235 ? -60.725 15.018 1.632   1.00 74.28  ? 235 ASP A CA   1 
ATOM   3561 C C    . ASP A 1 235 ? -59.623 15.791 2.347   1.00 67.36  ? 235 ASP A C    1 
ATOM   3562 O O    . ASP A 1 235 ? -58.512 15.265 2.530   1.00 63.38  ? 235 ASP A O    1 
ATOM   3563 C CB   . ASP A 1 235 ? -61.185 13.797 2.415   1.00 91.99  ? 235 ASP A CB   1 
ATOM   3564 C CG   . ASP A 1 235 ? -62.071 12.893 1.566   1.00 82.41  ? 235 ASP A CG   1 
ATOM   3565 O OD1  . ASP A 1 235 ? -62.836 13.436 0.734   1.00 97.48  ? 235 ASP A OD1  1 
ATOM   3566 O OD2  . ASP A 1 235 ? -61.965 11.654 1.703   1.00 79.53  ? 235 ASP A OD2  1 
ATOM   3567 H H    . ASP A 1 235 ? -60.105 13.724 0.284   1.00 78.03  ? 235 ASP A H    1 
ATOM   3568 H HA   . ASP A 1 235 ? -61.484 15.615 1.543   1.00 89.18  ? 235 ASP A HA   1 
ATOM   3569 H HB2  . ASP A 1 235 ? -60.410 13.287 2.699   1.00 110.43 ? 235 ASP A HB2  1 
ATOM   3570 H HB3  . ASP A 1 235 ? -61.694 14.085 3.189   1.00 110.43 ? 235 ASP A HB3  1 
ATOM   3571 N N    . PRO A 1 236 ? -59.853 17.039 2.745   1.00 63.05  ? 236 PRO A N    1 
ATOM   3572 C CA   . PRO A 1 236 ? -58.875 17.741 3.582   1.00 60.11  ? 236 PRO A CA   1 
ATOM   3573 C C    . PRO A 1 236 ? -58.314 16.884 4.702   1.00 67.59  ? 236 PRO A C    1 
ATOM   3574 O O    . PRO A 1 236 ? -58.841 15.814 5.049   1.00 60.85  ? 236 PRO A O    1 
ATOM   3575 C CB   . PRO A 1 236 ? -59.657 18.943 4.136   1.00 71.62  ? 236 PRO A CB   1 
ATOM   3576 C CG   . PRO A 1 236 ? -60.951 19.063 3.229   1.00 61.11  ? 236 PRO A CG   1 
ATOM   3577 C CD   . PRO A 1 236 ? -60.865 17.959 2.188   1.00 67.51  ? 236 PRO A CD   1 
ATOM   3578 H HA   . PRO A 1 236 ? -58.146 18.058 3.026   1.00 72.18  ? 236 PRO A HA   1 
ATOM   3579 H HB2  . PRO A 1 236 ? -59.898 18.780 5.061   1.00 85.99  ? 236 PRO A HB2  1 
ATOM   3580 H HB3  . PRO A 1 236 ? -59.115 19.745 4.071   1.00 85.99  ? 236 PRO A HB3  1 
ATOM   3581 H HG2  . PRO A 1 236 ? -61.742 18.950 3.779   1.00 73.39  ? 236 PRO A HG2  1 
ATOM   3582 H HG3  . PRO A 1 236 ? -60.966 19.933 2.801   1.00 73.39  ? 236 PRO A HG3  1 
ATOM   3583 H HD2  . PRO A 1 236 ? -61.720 17.511 2.088   1.00 81.06  ? 236 PRO A HD2  1 
ATOM   3584 H HD3  . PRO A 1 236 ? -60.575 18.313 1.333   1.00 81.06  ? 236 PRO A HD3  1 
ATOM   3585 N N    . VAL A 1 237 ? -57.215 17.353 5.263   1.00 62.70  ? 237 VAL A N    1 
ATOM   3586 C CA   . VAL A 1 237 ? -56.483 16.596 6.242   1.00 64.43  ? 237 VAL A CA   1 
ATOM   3587 C C    . VAL A 1 237 ? -56.951 17.017 7.618   1.00 71.56  ? 237 VAL A C    1 
ATOM   3588 O O    . VAL A 1 237 ? -57.680 18.005 7.800   1.00 64.22  ? 237 VAL A O    1 
ATOM   3589 C CB   . VAL A 1 237 ? -54.955 16.788 6.041   1.00 53.27  ? 237 VAL A CB   1 
ATOM   3590 C CG1  . VAL A 1 237 ? -54.523 16.409 4.613   1.00 53.71  ? 237 VAL A CG1  1 
ATOM   3591 C CG2  . VAL A 1 237 ? -54.560 18.210 6.302   1.00 51.11  ? 237 VAL A CG2  1 
ATOM   3592 H H    . VAL A 1 237 ? -56.871 18.122 5.085   1.00 75.30  ? 237 VAL A H    1 
ATOM   3593 H HA   . VAL A 1 237 ? -56.675 15.649 6.155   1.00 77.37  ? 237 VAL A HA   1 
ATOM   3594 H HB   . VAL A 1 237 ? -54.505 16.203 6.671   1.00 63.97  ? 237 VAL A HB   1 
ATOM   3595 H HG11 . VAL A 1 237 ? -54.956 17.006 3.983   1.00 64.50  ? 237 VAL A HG11 1 
ATOM   3596 H HG12 . VAL A 1 237 ? -53.559 16.496 4.541   1.00 64.50  ? 237 VAL A HG12 1 
ATOM   3597 H HG13 . VAL A 1 237 ? -54.786 15.493 4.435   1.00 64.50  ? 237 VAL A HG13 1 
ATOM   3598 H HG21 . VAL A 1 237 ? -53.615 18.315 6.107   1.00 61.39  ? 237 VAL A HG21 1 
ATOM   3599 H HG22 . VAL A 1 237 ? -55.083 18.793 5.730   1.00 61.39  ? 237 VAL A HG22 1 
ATOM   3600 H HG23 . VAL A 1 237 ? -54.731 18.420 7.233   1.00 61.39  ? 237 VAL A HG23 1 
ATOM   3601 N N    . ASP A 1 238 ? -56.545 16.244 8.649   1.00 62.95  ? 238 ASP A N    1 
ATOM   3602 C CA   . ASP A 1 238 ? -57.004 16.499 10.010  1.00 73.65  ? 238 ASP A CA   1 
ATOM   3603 C C    . ASP A 1 238 ? -56.564 17.885 10.451  1.00 71.40  ? 238 ASP A C    1 
ATOM   3604 O O    . ASP A 1 238 ? -55.361 18.180 10.469  1.00 55.36  ? 238 ASP A O    1 
ATOM   3605 C CB   . ASP A 1 238 ? -56.476 15.442 10.997  1.00 81.53  ? 238 ASP A CB   1 
ATOM   3606 C CG   . ASP A 1 238 ? -57.211 14.090 10.898  1.00 96.11  ? 238 ASP A CG   1 
ATOM   3607 O OD1  . ASP A 1 238 ? -58.380 14.058 10.414  1.00 91.65  ? 238 ASP A OD1  1 
ATOM   3608 O OD2  . ASP A 1 238 ? -56.610 13.069 11.333  1.00 82.63  ? 238 ASP A OD2  1 
ATOM   3609 H H    . ASP A 1 238 ? -56.009 15.576 8.576   1.00 75.59  ? 238 ASP A H    1 
ATOM   3610 H HA   . ASP A 1 238 ? -57.973 16.444 10.019  1.00 88.43  ? 238 ASP A HA   1 
ATOM   3611 H HB2  . ASP A 1 238 ? -55.537 15.283 10.814  1.00 97.89  ? 238 ASP A HB2  1 
ATOM   3612 H HB3  . ASP A 1 238 ? -56.586 15.775 11.901  1.00 97.89  ? 238 ASP A HB3  1 
ATOM   3613 N N    . THR A 1 239 ? -57.544 18.728 10.795  1.00 72.35  ? 239 THR A N    1 
ATOM   3614 C CA   . THR A 1 239 ? -57.293 20.095 11.236  1.00 63.12  ? 239 THR A CA   1 
ATOM   3615 C C    . THR A 1 239 ? -56.045 20.183 12.099  1.00 62.42  ? 239 THR A C    1 
ATOM   3616 O O    . THR A 1 239 ? -55.264 21.137 11.987  1.00 57.14  ? 239 THR A O    1 
ATOM   3617 C CB   . THR A 1 239 ? -58.495 20.638 12.015  1.00 70.35  ? 239 THR A CB   1 
ATOM   3618 O OG1  . THR A 1 239 ? -59.692 20.438 11.259  1.00 98.88  ? 239 THR A OG1  1 
ATOM   3619 C CG2  . THR A 1 239 ? -58.313 22.111 12.282  1.00 66.87  ? 239 THR A CG2  1 
ATOM   3620 H H    . THR A 1 239 ? -58.379 18.524 10.781  1.00 86.88  ? 239 THR A H    1 
ATOM   3621 H HA   . THR A 1 239 ? -57.156 20.646 10.449  1.00 75.79  ? 239 THR A HA   1 
ATOM   3622 H HB   . THR A 1 239 ? -58.571 20.172 12.862  1.00 84.47  ? 239 THR A HB   1 
ATOM   3623 H HG1  . THR A 1 239 ? -60.350 20.751 11.676  1.00 118.71 ? 239 THR A HG1  1 
ATOM   3624 H HG21 . THR A 1 239 ? -57.518 22.255 12.818  1.00 80.29  ? 239 THR A HG21 1 
ATOM   3625 H HG22 . THR A 1 239 ? -59.083 22.459 12.759  1.00 80.29  ? 239 THR A HG22 1 
ATOM   3626 H HG23 . THR A 1 239 ? -58.219 22.591 11.444  1.00 80.29  ? 239 THR A HG23 1 
ATOM   3627 N N    . GLU A 1 240 ? -55.864 19.184 12.965  1.00 58.26  ? 240 GLU A N    1 
ATOM   3628 C CA   . GLU A 1 240 ? -54.698 19.129 13.843  1.00 60.93  ? 240 GLU A CA   1 
ATOM   3629 C C    . GLU A 1 240 ? -53.395 19.160 13.047  1.00 62.09  ? 240 GLU A C    1 
ATOM   3630 O O    . GLU A 1 240 ? -52.348 19.626 13.540  1.00 51.54  ? 240 GLU A O    1 
ATOM   3631 C CB   . GLU A 1 240 ? -54.793 17.842 14.689  1.00 66.67  ? 240 GLU A CB   1 
ATOM   3632 C CG   . GLU A 1 240 ? -54.132 17.900 16.069  1.00 59.64  ? 240 GLU A CG   1 
ATOM   3633 C CD   . GLU A 1 240 ? -54.801 18.910 16.992  1.00 65.84  ? 240 GLU A CD   1 
ATOM   3634 O OE1  . GLU A 1 240 ? -54.185 19.971 17.251  1.00 60.34  ? 240 GLU A OE1  1 
ATOM   3635 O OE2  . GLU A 1 240 ? -55.941 18.648 17.443  1.00 64.94  ? 240 GLU A OE2  1 
ATOM   3636 H H    . GLU A 1 240 ? -56.404 18.523 13.063  1.00 69.97  ? 240 GLU A H    1 
ATOM   3637 H HA   . GLU A 1 240 ? -54.688 19.896 14.436  1.00 73.17  ? 240 GLU A HA   1 
ATOM   3638 H HB2  . GLU A 1 240 ? -55.731 17.638 14.828  1.00 80.05  ? 240 GLU A HB2  1 
ATOM   3639 H HB3  . GLU A 1 240 ? -54.368 17.122 14.196  1.00 80.05  ? 240 GLU A HB3  1 
ATOM   3640 H HG2  . GLU A 1 240 ? -54.189 17.027 16.486  1.00 71.62  ? 240 GLU A HG2  1 
ATOM   3641 H HG3  . GLU A 1 240 ? -53.202 18.158 15.965  1.00 71.62  ? 240 GLU A HG3  1 
ATOM   3642 N N    . PHE A 1 241 ? -53.426 18.619 11.835  1.00 62.71  ? 241 PHE A N    1 
ATOM   3643 C CA   . PHE A 1 241 ? -52.201 18.483 11.074  1.00 57.84  ? 241 PHE A CA   1 
ATOM   3644 C C    . PHE A 1 241 ? -51.828 19.824 10.463  1.00 47.27  ? 241 PHE A C    1 
ATOM   3645 O O    . PHE A 1 241 ? -50.692 20.285 10.610  1.00 45.29  ? 241 PHE A O    1 
ATOM   3646 C CB   . PHE A 1 241 ? -52.368 17.407 9.992   1.00 56.01  ? 241 PHE A CB   1 
ATOM   3647 C CG   . PHE A 1 241 ? -51.118 17.157 9.240   1.00 49.24  ? 241 PHE A CG   1 
ATOM   3648 C CD1  . PHE A 1 241 ? -50.087 16.469 9.832   1.00 48.95  ? 241 PHE A CD1  1 
ATOM   3649 C CD2  . PHE A 1 241 ? -50.933 17.699 7.967   1.00 47.46  ? 241 PHE A CD2  1 
ATOM   3650 C CE1  . PHE A 1 241 ? -48.881 16.287 9.158   1.00 50.72  ? 241 PHE A CE1  1 
ATOM   3651 C CE2  . PHE A 1 241 ? -49.738 17.540 7.300   1.00 44.47  ? 241 PHE A CE2  1 
ATOM   3652 C CZ   . PHE A 1 241 ? -48.719 16.834 7.875   1.00 43.99  ? 241 PHE A CZ   1 
ATOM   3653 H H    . PHE A 1 241 ? -54.133 18.329 11.441  1.00 75.30  ? 241 PHE A H    1 
ATOM   3654 H HA   . PHE A 1 241 ? -51.479 18.192 11.652  1.00 69.46  ? 241 PHE A HA   1 
ATOM   3655 H HB2  . PHE A 1 241 ? -52.637 16.575 10.412  1.00 67.26  ? 241 PHE A HB2  1 
ATOM   3656 H HB3  . PHE A 1 241 ? -53.046 17.695 9.361   1.00 67.26  ? 241 PHE A HB3  1 
ATOM   3657 H HD1  . PHE A 1 241 ? -50.195 16.121 10.688  1.00 58.79  ? 241 PHE A HD1  1 
ATOM   3658 H HD2  . PHE A 1 241 ? -51.625 18.172 7.564   1.00 57.01  ? 241 PHE A HD2  1 
ATOM   3659 H HE1  . PHE A 1 241 ? -48.189 15.808 9.555   1.00 60.92  ? 241 PHE A HE1  1 
ATOM   3660 H HE2  . PHE A 1 241 ? -49.625 17.914 6.456   1.00 53.42  ? 241 PHE A HE2  1 
ATOM   3661 H HZ   . PHE A 1 241 ? -47.918 16.717 7.416   1.00 52.84  ? 241 PHE A HZ   1 
ATOM   3662 N N    . ILE A 1 242 ? -52.799 20.455 9.791   1.00 49.38  ? 242 ILE A N    1 
ATOM   3663 C CA   . ILE A 1 242 ? -52.682 21.840 9.320   1.00 52.42  ? 242 ILE A CA   1 
ATOM   3664 C C    . ILE A 1 242 ? -52.121 22.730 10.422  1.00 51.20  ? 242 ILE A C    1 
ATOM   3665 O O    . ILE A 1 242 ? -51.152 23.484 10.221  1.00 50.17  ? 242 ILE A O    1 
ATOM   3666 C CB   . ILE A 1 242 ? -54.056 22.323 8.814   1.00 42.25  ? 242 ILE A CB   1 
ATOM   3667 C CG1  . ILE A 1 242 ? -54.474 21.471 7.608   1.00 47.48  ? 242 ILE A CG1  1 
ATOM   3668 C CG2  . ILE A 1 242 ? -54.045 23.781 8.397   1.00 47.39  ? 242 ILE A CG2  1 
ATOM   3669 C CD1  . ILE A 1 242 ? -55.939 21.655 7.119   1.00 45.30  ? 242 ILE A CD1  1 
ATOM   3670 H H    . ILE A 1 242 ? -53.553 20.094 9.589   1.00 59.30  ? 242 ILE A H    1 
ATOM   3671 H HA   . ILE A 1 242 ? -52.056 21.881 8.579   1.00 62.96  ? 242 ILE A HA   1 
ATOM   3672 H HB   . ILE A 1 242 ? -54.682 22.229 9.549   1.00 50.75  ? 242 ILE A HB   1 
ATOM   3673 H HG12 . ILE A 1 242 ? -53.893 21.694 6.864   1.00 57.02  ? 242 ILE A HG12 1 
ATOM   3674 H HG13 . ILE A 1 242 ? -54.366 20.537 7.845   1.00 57.02  ? 242 ILE A HG13 1 
ATOM   3675 H HG21 . ILE A 1 242 ? -53.304 23.930 7.790   1.00 56.92  ? 242 ILE A HG21 1 
ATOM   3676 H HG22 . ILE A 1 242 ? -54.882 23.989 7.954   1.00 56.92  ? 242 ILE A HG22 1 
ATOM   3677 H HG23 . ILE A 1 242 ? -53.942 24.334 9.187   1.00 56.92  ? 242 ILE A HG23 1 
ATOM   3678 H HD11 . ILE A 1 242 ? -56.479 21.983 7.855   1.00 54.41  ? 242 ILE A HD11 1 
ATOM   3679 H HD12 . ILE A 1 242 ? -55.950 22.295 6.390   1.00 54.41  ? 242 ILE A HD12 1 
ATOM   3680 H HD13 . ILE A 1 242 ? -56.279 20.800 6.814   1.00 54.41  ? 242 ILE A HD13 1 
ATOM   3681 N N    . ASN A 1 243 ? -52.668 22.602 11.624  1.00 50.75  ? 243 ASN A N    1 
ATOM   3682 C CA   . ASN A 1 243 ? -52.246 23.491 12.704  1.00 46.95  ? 243 ASN A CA   1 
ATOM   3683 C C    . ASN A 1 243 ? -50.794 23.248 13.107  1.00 50.92  ? 243 ASN A C    1 
ATOM   3684 O O    . ASN A 1 243 ? -50.084 24.195 13.482  1.00 46.20  ? 243 ASN A O    1 
ATOM   3685 C CB   . ASN A 1 243 ? -53.141 23.276 13.918  1.00 51.58  ? 243 ASN A CB   1 
ATOM   3686 C CG   . ASN A 1 243 ? -54.374 24.121 13.894  1.00 57.48  ? 243 ASN A CG   1 
ATOM   3687 O OD1  . ASN A 1 243 ? -54.728 24.780 12.881  1.00 51.60  ? 243 ASN A OD1  1 
ATOM   3688 N ND2  . ASN A 1 243 ? -55.076 24.097 15.029  1.00 66.35  ? 243 ASN A ND2  1 
ATOM   3689 H H    . ASN A 1 243 ? -53.269 22.026 11.838  1.00 60.95  ? 243 ASN A H    1 
ATOM   3690 H HA   . ASN A 1 243 ? -52.332 24.407 12.398  1.00 56.39  ? 243 ASN A HA   1 
ATOM   3691 H HB2  . ASN A 1 243 ? -53.417 22.347 13.945  1.00 61.95  ? 243 ASN A HB2  1 
ATOM   3692 H HB3  . ASN A 1 243 ? -52.642 23.498 14.719  1.00 61.95  ? 243 ASN A HB3  1 
ATOM   3693 H HD21 . ASN A 1 243 ? -54.805 23.622 15.692  1.00 79.67  ? 243 ASN A HD21 1 
ATOM   3694 H HD22 . ASN A 1 243 ? -55.799 24.557 15.097  1.00 79.67  ? 243 ASN A HD22 1 
ATOM   3695 N N    . LYS A 1 244 ? -50.335 21.985 13.083  1.00 49.54  ? 244 LYS A N    1 
ATOM   3696 C CA   . LYS A 1 244 ? -48.945 21.741 13.441  1.00 53.19  ? 244 LYS A CA   1 
ATOM   3697 C C    . LYS A 1 244 ? -48.011 22.275 12.352  1.00 40.41  ? 244 LYS A C    1 
ATOM   3698 O O    . LYS A 1 244 ? -46.986 22.879 12.658  1.00 51.20  ? 244 LYS A O    1 
ATOM   3699 C CB   . LYS A 1 244 ? -48.750 20.242 13.733  1.00 57.23  ? 244 LYS A CB   1 
ATOM   3700 C CG   . LYS A 1 244 ? -47.364 19.785 14.357  1.00 53.56  ? 244 LYS A CG   1 
ATOM   3701 C CD   . LYS A 1 244 ? -46.803 20.639 15.526  1.00 66.70  ? 244 LYS A CD   1 
ATOM   3702 C CE   . LYS A 1 244 ? -46.024 19.773 16.595  1.00 72.63  ? 244 LYS A CE   1 
ATOM   3703 N NZ   . LYS A 1 244 ? -44.830 20.392 17.339  1.00 66.50  ? 244 LYS A NZ   1 
ATOM   3704 H H    . LYS A 1 244 ? -50.794 21.288 12.872  1.00 59.50  ? 244 LYS A H    1 
ATOM   3705 H HA   . LYS A 1 244 ? -48.706 22.206 14.259  1.00 63.87  ? 244 LYS A HA   1 
ATOM   3706 H HB2  . LYS A 1 244 ? -49.440 19.969 14.358  1.00 68.73  ? 244 LYS A HB2  1 
ATOM   3707 H HB3  . LYS A 1 244 ? -48.851 19.761 12.897  1.00 68.73  ? 244 LYS A HB3  1 
ATOM   3708 H HG2  . LYS A 1 244 ? -47.469 18.882 14.694  1.00 64.32  ? 244 LYS A HG2  1 
ATOM   3709 H HG3  . LYS A 1 244 ? -46.698 19.801 13.652  1.00 64.32  ? 244 LYS A HG3  1 
ATOM   3710 H HD2  . LYS A 1 244 ? -46.188 21.299 15.169  1.00 80.09  ? 244 LYS A HD2  1 
ATOM   3711 H HD3  . LYS A 1 244 ? -47.539 21.081 15.977  1.00 80.09  ? 244 LYS A HD3  1 
ATOM   3712 H HE2  . LYS A 1 244 ? -46.662 19.509 17.277  1.00 87.21  ? 244 LYS A HE2  1 
ATOM   3713 H HE3  . LYS A 1 244 ? -45.682 18.987 16.140  1.00 87.21  ? 244 LYS A HE3  1 
ATOM   3714 H HZ1  . LYS A 1 244 ? -44.109 20.387 16.817  1.00 79.85  ? 244 LYS A HZ1  1 
ATOM   3715 H HZ2  . LYS A 1 244 ? -44.656 19.925 18.077  1.00 79.85  ? 244 LYS A HZ2  1 
ATOM   3716 H HZ3  . LYS A 1 244 ? -45.016 21.232 17.567  1.00 79.85  ? 244 LYS A HZ3  1 
ATOM   3717 N N    . PHE A 1 245 ? -48.388 22.134 11.087  1.00 45.05  ? 245 PHE A N    1 
ATOM   3718 C CA   . PHE A 1 245 ? -47.646 22.773 9.990   1.00 51.09  ? 245 PHE A CA   1 
ATOM   3719 C C    . PHE A 1 245 ? -47.541 24.277 10.207  1.00 41.21  ? 245 PHE A C    1 
ATOM   3720 O O    . PHE A 1 245 ? -46.456 24.858 10.120  1.00 41.41  ? 245 PHE A O    1 
ATOM   3721 C CB   . PHE A 1 245 ? -48.360 22.471 8.661   1.00 46.88  ? 245 PHE A CB   1 
ATOM   3722 C CG   . PHE A 1 245 ? -47.679 22.995 7.410   1.00 45.64  ? 245 PHE A CG   1 
ATOM   3723 C CD1  . PHE A 1 245 ? -47.864 24.301 6.990   1.00 47.65  ? 245 PHE A CD1  1 
ATOM   3724 C CD2  . PHE A 1 245 ? -46.949 22.134 6.591   1.00 47.09  ? 245 PHE A CD2  1 
ATOM   3725 C CE1  . PHE A 1 245 ? -47.274 24.757 5.807   1.00 42.97  ? 245 PHE A CE1  1 
ATOM   3726 C CE2  . PHE A 1 245 ? -46.358 22.563 5.412   1.00 40.97  ? 245 PHE A CE2  1 
ATOM   3727 C CZ   . PHE A 1 245 ? -46.526 23.883 5.006   1.00 44.85  ? 245 PHE A CZ   1 
ATOM   3728 H H    . PHE A 1 245 ? -49.068 21.675 10.829  1.00 54.11  ? 245 PHE A H    1 
ATOM   3729 H HA   . PHE A 1 245 ? -46.746 22.413 9.954   1.00 61.35  ? 245 PHE A HA   1 
ATOM   3730 H HB2  . PHE A 1 245 ? -48.432 21.508 8.567   1.00 56.31  ? 245 PHE A HB2  1 
ATOM   3731 H HB3  . PHE A 1 245 ? -49.245 22.868 8.694   1.00 56.31  ? 245 PHE A HB3  1 
ATOM   3732 H HD1  . PHE A 1 245 ? -48.385 24.879 7.499   1.00 57.24  ? 245 PHE A HD1  1 
ATOM   3733 H HD2  . PHE A 1 245 ? -46.855 21.244 6.845   1.00 56.56  ? 245 PHE A HD2  1 
ATOM   3734 H HE1  . PHE A 1 245 ? -47.378 25.645 5.551   1.00 51.62  ? 245 PHE A HE1  1 
ATOM   3735 H HE2  . PHE A 1 245 ? -45.855 21.973 4.898   1.00 49.21  ? 245 PHE A HE2  1 
ATOM   3736 H HZ   . PHE A 1 245 ? -46.146 24.183 4.212   1.00 53.87  ? 245 PHE A HZ   1 
ATOM   3737 N N    . LEU A 1 246 ? -48.677 24.918 10.494  1.00 41.80  ? 246 LEU A N    1 
ATOM   3738 C CA   . LEU A 1 246 ? -48.708 26.358 10.672  1.00 41.45  ? 246 LEU A CA   1 
ATOM   3739 C C    . LEU A 1 246 ? -47.899 26.790 11.864  1.00 41.98  ? 246 LEU A C    1 
ATOM   3740 O O    . LEU A 1 246 ? -47.472 27.940 11.920  1.00 39.64  ? 246 LEU A O    1 
ATOM   3741 C CB   . LEU A 1 246 ? -50.143 26.836 10.829  1.00 43.64  ? 246 LEU A CB   1 
ATOM   3742 C CG   . LEU A 1 246 ? -51.030 26.588 9.617   1.00 41.02  ? 246 LEU A CG   1 
ATOM   3743 C CD1  . LEU A 1 246 ? -52.483 26.806 9.953   1.00 44.58  ? 246 LEU A CD1  1 
ATOM   3744 C CD2  . LEU A 1 246 ? -50.576 27.512 8.468   1.00 44.45  ? 246 LEU A CD2  1 
ATOM   3745 H H    . LEU A 1 246 ? -49.442 24.537 10.590  1.00 50.22  ? 246 LEU A H    1 
ATOM   3746 H HA   . LEU A 1 246 ? -48.331 26.771 9.880   1.00 49.79  ? 246 LEU A HA   1 
ATOM   3747 H HB2  . LEU A 1 246 ? -50.540 26.373 11.583  1.00 52.42  ? 246 LEU A HB2  1 
ATOM   3748 H HB3  . LEU A 1 246 ? -50.132 27.791 10.994  1.00 52.42  ? 246 LEU A HB3  1 
ATOM   3749 H HG   . LEU A 1 246 ? -50.948 25.666 9.330   1.00 49.27  ? 246 LEU A HG   1 
ATOM   3750 H HD11 . LEU A 1 246 ? -52.589 27.690 10.338  1.00 53.55  ? 246 LEU A HD11 1 
ATOM   3751 H HD12 . LEU A 1 246 ? -52.764 26.131 10.591  1.00 53.55  ? 246 LEU A HD12 1 
ATOM   3752 H HD13 . LEU A 1 246 ? -53.009 26.733 9.141   1.00 53.55  ? 246 LEU A HD13 1 
ATOM   3753 H HD21 . LEU A 1 246 ? -50.333 28.376 8.835   1.00 53.39  ? 246 LEU A HD21 1 
ATOM   3754 H HD22 . LEU A 1 246 ? -51.305 27.613 7.837   1.00 53.39  ? 246 LEU A HD22 1 
ATOM   3755 H HD23 . LEU A 1 246 ? -49.810 27.113 8.026   1.00 53.39  ? 246 LEU A HD23 1 
ATOM   3756 N N    . GLU A 1 247 ? -47.720 25.928 12.861  1.00 42.77  ? 247 GLU A N    1 
ATOM   3757 C CA   . GLU A 1 247 ? -46.767 26.275 13.913  1.00 47.33  ? 247 GLU A CA   1 
ATOM   3758 C C    . GLU A 1 247 ? -45.431 26.662 13.306  1.00 48.94  ? 247 GLU A C    1 
ATOM   3759 O O    . GLU A 1 247 ? -44.741 27.556 13.809  1.00 46.20  ? 247 GLU A O    1 
ATOM   3760 C CB   . GLU A 1 247 ? -46.541 25.100 14.868  1.00 52.22  ? 247 GLU A CB   1 
ATOM   3761 C CG   . GLU A 1 247 ? -47.563 24.878 15.970  1.00 55.90  ? 247 GLU A CG   1 
ATOM   3762 C CD   . GLU A 1 247 ? -47.162 23.678 16.845  1.00 60.16  ? 247 GLU A CD   1 
ATOM   3763 O OE1  . GLU A 1 247 ? -48.058 22.889 17.229  1.00 62.94  ? 247 GLU A OE1  1 
ATOM   3764 O OE2  . GLU A 1 247 ? -45.949 23.508 17.118  1.00 56.07  ? 247 GLU A OE2  1 
ATOM   3765 H H    . GLU A 1 247 ? -48.118 25.171 12.949  1.00 51.37  ? 247 GLU A H    1 
ATOM   3766 H HA   . GLU A 1 247 ? -47.138 27.013 14.422  1.00 56.84  ? 247 GLU A HA   1 
ATOM   3767 H HB2  . GLU A 1 247 ? -46.520 24.288 14.338  1.00 62.72  ? 247 GLU A HB2  1 
ATOM   3768 H HB3  . GLU A 1 247 ? -45.684 25.233 15.304  1.00 62.72  ? 247 GLU A HB3  1 
ATOM   3769 H HG2  . GLU A 1 247 ? -47.611 25.667 16.532  1.00 67.13  ? 247 GLU A HG2  1 
ATOM   3770 H HG3  . GLU A 1 247 ? -48.431 24.697 15.577  1.00 67.13  ? 247 GLU A HG3  1 
ATOM   3771 N N    . PHE A 1 248 ? -45.021 25.934 12.258  1.00 48.32  ? 248 PHE A N    1 
ATOM   3772 C CA   . PHE A 1 248 ? -43.783 26.236 11.550  1.00 44.66  ? 248 PHE A CA   1 
ATOM   3773 C C    . PHE A 1 248 ? -43.993 27.389 10.570  1.00 37.21  ? 248 PHE A C    1 
ATOM   3774 O O    . PHE A 1 248 ? -43.301 28.399 10.636  1.00 39.77  ? 248 PHE A O    1 
ATOM   3775 C CB   . PHE A 1 248 ? -43.297 24.982 10.818  1.00 39.61  ? 248 PHE A CB   1 
ATOM   3776 C CG   . PHE A 1 248 ? -42.084 25.200 9.980   1.00 42.65  ? 248 PHE A CG   1 
ATOM   3777 C CD1  . PHE A 1 248 ? -40.824 25.344 10.568  1.00 41.98  ? 248 PHE A CD1  1 
ATOM   3778 C CD2  . PHE A 1 248 ? -42.184 25.219 8.603   1.00 38.49  ? 248 PHE A CD2  1 
ATOM   3779 C CE1  . PHE A 1 248 ? -39.665 25.530 9.777   1.00 45.81  ? 248 PHE A CE1  1 
ATOM   3780 C CE2  . PHE A 1 248 ? -41.047 25.391 7.799   1.00 38.15  ? 248 PHE A CE2  1 
ATOM   3781 C CZ   . PHE A 1 248 ? -39.776 25.570 8.388   1.00 41.11  ? 248 PHE A CZ   1 
ATOM   3782 H H    . PHE A 1 248 ? -45.447 25.259 11.939  1.00 58.04  ? 248 PHE A H    1 
ATOM   3783 H HA   . PHE A 1 248 ? -43.098 26.500 12.184  1.00 53.64  ? 248 PHE A HA   1 
ATOM   3784 H HB2  . PHE A 1 248 ? -43.083 24.301 11.475  1.00 47.58  ? 248 PHE A HB2  1 
ATOM   3785 H HB3  . PHE A 1 248 ? -44.006 24.668 10.235  1.00 47.58  ? 248 PHE A HB3  1 
ATOM   3786 H HD1  . PHE A 1 248 ? -40.746 25.316 11.494  1.00 50.42  ? 248 PHE A HD1  1 
ATOM   3787 H HD2  . PHE A 1 248 ? -43.018 25.116 8.203   1.00 46.24  ? 248 PHE A HD2  1 
ATOM   3788 H HE1  . PHE A 1 248 ? -38.834 25.625 10.182  1.00 55.02  ? 248 PHE A HE1  1 
ATOM   3789 H HE2  . PHE A 1 248 ? -41.131 25.387 6.873   1.00 45.84  ? 248 PHE A HE2  1 
ATOM   3790 H HZ   . PHE A 1 248 ? -39.025 25.713 7.858   1.00 49.38  ? 248 PHE A HZ   1 
ATOM   3791 N N    . SER A 1 249 ? -44.956 27.269 9.665   1.00 32.63  ? 249 SER A N    1 
ATOM   3792 C CA   . SER A 1 249 ? -45.034 28.265 8.608   1.00 31.43  ? 249 SER A CA   1 
ATOM   3793 C C    . SER A 1 249 ? -45.415 29.635 9.160   1.00 39.69  ? 249 SER A C    1 
ATOM   3794 O O    . SER A 1 249 ? -44.978 30.658 8.612   1.00 36.33  ? 249 SER A O    1 
ATOM   3795 C CB   . SER A 1 249 ? -46.011 27.808 7.526   1.00 39.67  ? 249 SER A CB   1 
ATOM   3796 O OG   . SER A 1 249 ? -47.357 27.783 7.995   1.00 40.85  ? 249 SER A OG   1 
ATOM   3797 H H    . SER A 1 249 ? -45.551 26.649 9.641   1.00 39.20  ? 249 SER A H    1 
ATOM   3798 H HA   . SER A 1 249 ? -44.165 28.354 8.187   1.00 37.77  ? 249 SER A HA   1 
ATOM   3799 H HB2  . SER A 1 249 ? -45.955 28.422 6.777   1.00 47.65  ? 249 SER A HB2  1 
ATOM   3800 H HB3  . SER A 1 249 ? -45.765 26.914 7.242   1.00 47.65  ? 249 SER A HB3  1 
ATOM   3801 H HG   . SER A 1 249 ? -47.724 28.525 7.853   1.00 49.06  ? 249 SER A HG   1 
ATOM   3802 N N    . ASN A 1 250 ? -46.161 29.690 10.272  1.00 32.78  ? 250 ASN A N    1 
ATOM   3803 C CA   . ASN A 1 250 ? -46.460 30.984 10.866  1.00 38.46  ? 250 ASN A CA   1 
ATOM   3804 C C    . ASN A 1 250 ? -45.196 31.703 11.289  1.00 39.39  ? 250 ASN A C    1 
ATOM   3805 O O    . ASN A 1 250 ? -45.094 32.925 11.146  1.00 35.79  ? 250 ASN A O    1 
ATOM   3806 C CB   . ASN A 1 250 ? -47.379 30.834 12.080  1.00 38.96  ? 250 ASN A CB   1 
ATOM   3807 C CG   . ASN A 1 250 ? -48.816 30.822 11.712  1.00 43.55  ? 250 ASN A CG   1 
ATOM   3808 O OD1  . ASN A 1 250 ? -49.202 31.162 10.604  1.00 43.08  ? 250 ASN A OD1  1 
ATOM   3809 N ND2  . ASN A 1 250 ? -49.645 30.444 12.653  1.00 47.09  ? 250 ASN A ND2  1 
ATOM   3810 H H    . ASN A 1 250 ? -46.493 29.012 10.684  1.00 39.38  ? 250 ASN A H    1 
ATOM   3811 H HA   . ASN A 1 250 ? -46.920 31.513 10.195  1.00 46.20  ? 250 ASN A HA   1 
ATOM   3812 H HB2  . ASN A 1 250 ? -47.177 29.998 12.528  1.00 46.80  ? 250 ASN A HB2  1 
ATOM   3813 H HB3  . ASN A 1 250 ? -47.230 31.579 12.684  1.00 46.80  ? 250 ASN A HB3  1 
ATOM   3814 H HD21 . ASN A 1 250 ? -50.490 30.418 12.496  1.00 56.56  ? 250 ASN A HD21 1 
ATOM   3815 H HD22 . ASN A 1 250 ? -49.345 30.222 13.428  1.00 56.56  ? 250 ASN A HD22 1 
ATOM   3816 N N    . ARG A 1 251 ? -44.254 30.976 11.878  1.00 39.96  ? 251 ARG A N    1 
ATOM   3817 C CA   . ARG A 1 251 ? -43.005 31.580 12.329  1.00 40.35  ? 251 ARG A CA   1 
ATOM   3818 C C    . ARG A 1 251 ? -42.153 32.039 11.158  1.00 38.64  ? 251 ARG A C    1 
ATOM   3819 O O    . ARG A 1 251 ? -41.471 33.063 11.240  1.00 34.15  ? 251 ARG A O    1 
ATOM   3820 C CB   . ARG A 1 251 ? -42.206 30.583 13.184  1.00 45.51  ? 251 ARG A CB   1 
ATOM   3821 C CG   . ARG A 1 251 ? -42.770 30.433 14.614  1.00 50.77  ? 251 ARG A CG   1 
ATOM   3822 C CD   . ARG A 1 251 ? -41.866 29.671 15.565  1.00 54.67  ? 251 ARG A CD   1 
ATOM   3823 N NE   . ARG A 1 251 ? -41.526 28.356 15.051  1.00 58.15  ? 251 ARG A NE   1 
ATOM   3824 C CZ   . ARG A 1 251 ? -41.948 27.207 15.562  1.00 63.35  ? 251 ARG A CZ   1 
ATOM   3825 N NH1  . ARG A 1 251 ? -42.756 27.186 16.624  1.00 62.08  ? 251 ARG A NH1  1 
ATOM   3826 N NH2  . ARG A 1 251 ? -41.545 26.067 15.012  1.00 53.33  ? 251 ARG A NH2  1 
ATOM   3827 H H    . ARG A 1 251 ? -44.311 30.132 12.030  1.00 48.00  ? 251 ARG A H    1 
ATOM   3828 H HA   . ARG A 1 251 ? -43.226 32.350 12.875  1.00 48.47  ? 251 ARG A HA   1 
ATOM   3829 H HB2  . ARG A 1 251 ? -42.231 29.711 12.759  1.00 54.67  ? 251 ARG A HB2  1 
ATOM   3830 H HB3  . ARG A 1 251 ? -41.289 30.892 13.255  1.00 54.67  ? 251 ARG A HB3  1 
ATOM   3831 H HG2  . ARG A 1 251 ? -42.909 31.318 14.987  1.00 60.97  ? 251 ARG A HG2  1 
ATOM   3832 H HG3  . ARG A 1 251 ? -43.614 29.957 14.566  1.00 60.97  ? 251 ARG A HG3  1 
ATOM   3833 H HD2  . ARG A 1 251 ? -41.043 30.169 15.692  1.00 65.65  ? 251 ARG A HD2  1 
ATOM   3834 H HD3  . ARG A 1 251 ? -42.319 29.557 16.415  1.00 65.65  ? 251 ARG A HD3  1 
ATOM   3835 H HE   . ARG A 1 251 ? -41.011 28.319 14.363  1.00 69.83  ? 251 ARG A HE   1 
ATOM   3836 H HH11 . ARG A 1 251 ? -43.009 27.924 16.986  1.00 74.55  ? 251 ARG A HH11 1 
ATOM   3837 H HH12 . ARG A 1 251 ? -43.023 26.435 16.946  1.00 74.55  ? 251 ARG A HH12 1 
ATOM   3838 H HH21 . ARG A 1 251 ? -41.017 26.080 14.333  1.00 64.05  ? 251 ARG A HH21 1 
ATOM   3839 H HH22 . ARG A 1 251 ? -41.812 25.316 15.334  1.00 64.05  ? 251 ARG A HH22 1 
ATOM   3840 N N    . VAL A 1 252 ? -42.158 31.267 10.076  1.00 36.52  ? 252 VAL A N    1 
ATOM   3841 C CA   . VAL A 1 252 ? -41.399 31.641 8.890   1.00 41.93  ? 252 VAL A CA   1 
ATOM   3842 C C    . VAL A 1 252 ? -42.034 32.858 8.235   1.00 38.80  ? 252 VAL A C    1 
ATOM   3843 O O    . VAL A 1 252 ? -41.343 33.818 7.886   1.00 35.85  ? 252 VAL A O    1 
ATOM   3844 C CB   . VAL A 1 252 ? -41.306 30.455 7.905   1.00 35.15  ? 252 VAL A CB   1 
ATOM   3845 C CG1  . VAL A 1 252 ? -40.748 30.909 6.547   1.00 36.07  ? 252 VAL A CG1  1 
ATOM   3846 C CG2  . VAL A 1 252 ? -40.441 29.323 8.471   1.00 40.70  ? 252 VAL A CG2  1 
ATOM   3847 H H    . VAL A 1 252 ? -42.589 30.527 10.003  1.00 43.87  ? 252 VAL A H    1 
ATOM   3848 H HA   . VAL A 1 252 ? -40.495 31.871 9.159   1.00 50.37  ? 252 VAL A HA   1 
ATOM   3849 H HB   . VAL A 1 252 ? -42.204 30.112 7.774   1.00 42.23  ? 252 VAL A HB   1 
ATOM   3850 H HG11 . VAL A 1 252 ? -39.904 31.367 6.689   1.00 43.34  ? 252 VAL A HG11 1 
ATOM   3851 H HG12 . VAL A 1 252 ? -41.384 31.510 6.129   1.00 43.34  ? 252 VAL A HG12 1 
ATOM   3852 H HG13 . VAL A 1 252 ? -40.611 30.130 5.985   1.00 43.34  ? 252 VAL A HG13 1 
ATOM   3853 H HG21 . VAL A 1 252 ? -39.517 29.617 8.499   1.00 48.89  ? 252 VAL A HG21 1 
ATOM   3854 H HG22 . VAL A 1 252 ? -40.524 28.545 7.897   1.00 48.89  ? 252 VAL A HG22 1 
ATOM   3855 H HG23 . VAL A 1 252 ? -40.748 29.108 9.366   1.00 48.89  ? 252 VAL A HG23 1 
ATOM   3856 N N    . TYR A 1 253 ? -43.365 32.852 8.072   1.00 32.07  ? 253 TYR A N    1 
ATOM   3857 C CA   . TYR A 1 253 ? -44.008 33.990 7.439   1.00 38.77  ? 253 TYR A CA   1 
ATOM   3858 C C    . TYR A 1 253 ? -43.946 35.229 8.329   1.00 39.39  ? 253 TYR A C    1 
ATOM   3859 O O    . TYR A 1 253 ? -43.902 36.360 7.818   1.00 35.01  ? 253 TYR A O    1 
ATOM   3860 C CB   . TYR A 1 253 ? -45.453 33.652 7.059   1.00 34.59  ? 253 TYR A CB   1 
ATOM   3861 C CG   . TYR A 1 253 ? -45.506 32.818 5.810   1.00 30.59  ? 253 TYR A CG   1 
ATOM   3862 C CD1  . TYR A 1 253 ? -45.023 33.289 4.611   1.00 32.61  ? 253 TYR A CD1  1 
ATOM   3863 C CD2  . TYR A 1 253 ? -46.103 31.558 5.830   1.00 39.27  ? 253 TYR A CD2  1 
ATOM   3864 C CE1  . TYR A 1 253 ? -45.078 32.501 3.435   1.00 31.98  ? 253 TYR A CE1  1 
ATOM   3865 C CE2  . TYR A 1 253 ? -46.179 30.793 4.705   1.00 32.67  ? 253 TYR A CE2  1 
ATOM   3866 C CZ   . TYR A 1 253 ? -45.663 31.238 3.512   1.00 32.14  ? 253 TYR A CZ   1 
ATOM   3867 O OH   . TYR A 1 253 ? -45.751 30.419 2.405   1.00 32.41  ? 253 TYR A OH   1 
ATOM   3868 H H    . TYR A 1 253 ? -43.894 32.218 8.313   1.00 38.53  ? 253 TYR A H    1 
ATOM   3869 H HA   . TYR A 1 253 ? -43.541 34.195 6.614   1.00 46.57  ? 253 TYR A HA   1 
ATOM   3870 H HB2  . TYR A 1 253 ? -45.867 33.152 7.780   1.00 41.56  ? 253 TYR A HB2  1 
ATOM   3871 H HB3  . TYR A 1 253 ? -45.945 34.474 6.901   1.00 41.56  ? 253 TYR A HB3  1 
ATOM   3872 H HD1  . TYR A 1 253 ? -44.653 34.141 4.571   1.00 39.18  ? 253 TYR A HD1  1 
ATOM   3873 H HD2  . TYR A 1 253 ? -46.456 31.234 6.627   1.00 47.17  ? 253 TYR A HD2  1 
ATOM   3874 H HE1  . TYR A 1 253 ? -44.732 32.818 2.632   1.00 38.42  ? 253 TYR A HE1  1 
ATOM   3875 H HE2  . TYR A 1 253 ? -46.585 29.958 4.746   1.00 39.26  ? 253 TYR A HE2  1 
ATOM   3876 H HH   . TYR A 1 253 ? -46.419 29.915 2.473   1.00 38.94  ? 253 TYR A HH   1 
ATOM   3877 N N    . GLU A 1 254 ? -43.924 35.043 9.652   1.00 39.05  ? 254 GLU A N    1 
ATOM   3878 C CA   . GLU A 1 254 ? -43.763 36.187 10.533  1.00 40.90  ? 254 GLU A CA   1 
ATOM   3879 C C    . GLU A 1 254 ? -42.381 36.808 10.363  1.00 39.43  ? 254 GLU A C    1 
ATOM   3880 O O    . GLU A 1 254 ? -42.251 38.036 10.356  1.00 35.69  ? 254 GLU A O    1 
ATOM   3881 C CB   . GLU A 1 254 ? -43.996 35.779 11.998  1.00 41.95  ? 254 GLU A CB   1 
ATOM   3882 C CG   . GLU A 1 254 ? -45.435 35.323 12.338  1.00 53.76  ? 254 GLU A CG   1 
ATOM   3883 C CD   . GLU A 1 254 ? -46.339 36.472 12.813  1.00 56.02  ? 254 GLU A CD   1 
ATOM   3884 O OE1  . GLU A 1 254 ? -47.596 36.271 12.933  1.00 59.01  ? 254 GLU A OE1  1 
ATOM   3885 O OE2  . GLU A 1 254 ? -45.781 37.570 13.067  1.00 61.42  ? 254 GLU A OE2  1 
ATOM   3886 H H    . GLU A 1 254 ? -43.999 34.284 10.048  1.00 46.91  ? 254 GLU A H    1 
ATOM   3887 H HA   . GLU A 1 254 ? -44.431 36.853 10.307  1.00 49.13  ? 254 GLU A HA   1 
ATOM   3888 H HB2  . GLU A 1 254 ? -43.401 35.042 12.208  1.00 50.40  ? 254 GLU A HB2  1 
ATOM   3889 H HB3  . GLU A 1 254 ? -43.792 36.540 12.564  1.00 50.40  ? 254 GLU A HB3  1 
ATOM   3890 H HG2  . GLU A 1 254 ? -45.837 34.935 11.546  1.00 64.56  ? 254 GLU A HG2  1 
ATOM   3891 H HG3  . GLU A 1 254 ? -45.395 34.663 13.048  1.00 64.56  ? 254 GLU A HG3  1 
ATOM   3892 N N    . ALA A 1 255 ? -41.337 35.975 10.245  1.00 39.82  ? 255 ALA A N    1 
ATOM   3893 C CA   . ALA A 1 255 ? -40.006 36.496 9.966   1.00 44.02  ? 255 ALA A CA   1 
ATOM   3894 C C    . ALA A 1 255 ? -39.952 37.131 8.588   1.00 40.28  ? 255 ALA A C    1 
ATOM   3895 O O    . ALA A 1 255 ? -39.455 38.256 8.434   1.00 37.22  ? 255 ALA A O    1 
ATOM   3896 C CB   . ALA A 1 255 ? -38.949 35.392 10.071  1.00 38.71  ? 255 ALA A CB   1 
ATOM   3897 H H    . ALA A 1 255 ? -41.378 35.119 10.323  1.00 47.83  ? 255 ALA A H    1 
ATOM   3898 H HA   . ALA A 1 255 ? -39.801 37.169 10.634  1.00 52.88  ? 255 ALA A HA   1 
ATOM   3899 H HB1  . ALA A 1 255 ? -38.072 35.779 9.922   1.00 46.51  ? 255 ALA A HB1  1 
ATOM   3900 H HB2  . ALA A 1 255 ? -39.131 34.716 9.400   1.00 46.51  ? 255 ALA A HB2  1 
ATOM   3901 H HB3  . ALA A 1 255 ? -38.991 34.999 10.957  1.00 46.51  ? 255 ALA A HB3  1 
ATOM   3902 N N    . LEU A 1 256 ? -40.474 36.436 7.567   1.00 35.91  ? 256 LEU A N    1 
ATOM   3903 C CA   . LEU A 1 256 ? -40.508 37.039 6.234   1.00 37.38  ? 256 LEU A CA   1 
ATOM   3904 C C    . LEU A 1 256 ? -41.227 38.380 6.269   1.00 38.81  ? 256 LEU A C    1 
ATOM   3905 O O    . LEU A 1 256 ? -40.810 39.342 5.617   1.00 39.92  ? 256 LEU A O    1 
ATOM   3906 C CB   . LEU A 1 256 ? -41.200 36.119 5.216   1.00 34.90  ? 256 LEU A CB   1 
ATOM   3907 C CG   . LEU A 1 256 ? -40.548 34.769 4.860   1.00 41.49  ? 256 LEU A CG   1 
ATOM   3908 C CD1  . LEU A 1 256 ? -41.073 34.045 3.622   1.00 41.37  ? 256 LEU A CD1  1 
ATOM   3909 C CD2  . LEU A 1 256 ? -39.029 34.964 4.710   1.00 39.75  ? 256 LEU A CD2  1 
ATOM   3910 H H    . LEU A 1 256 ? -40.803 35.643 7.621   1.00 43.14  ? 256 LEU A H    1 
ATOM   3911 H HA   . LEU A 1 256 ? -39.591 37.165 5.944   1.00 44.91  ? 256 LEU A HA   1 
ATOM   3912 H HB2  . LEU A 1 256 ? -42.082 35.914 5.564   1.00 41.93  ? 256 LEU A HB2  1 
ATOM   3913 H HB3  . LEU A 1 256 ? -41.277 36.613 4.385   1.00 41.93  ? 256 LEU A HB3  1 
ATOM   3914 H HG   . LEU A 1 256 ? -40.785 34.183 5.595   1.00 49.84  ? 256 LEU A HG   1 
ATOM   3915 H HD11 . LEU A 1 256 ? -41.041 34.650 2.865   1.00 49.70  ? 256 LEU A HD11 1 
ATOM   3916 H HD12 . LEU A 1 256 ? -41.987 33.765 3.784   1.00 49.70  ? 256 LEU A HD12 1 
ATOM   3917 H HD13 . LEU A 1 256 ? -40.515 33.270 3.450   1.00 49.70  ? 256 LEU A HD13 1 
ATOM   3918 H HD21 . LEU A 1 256 ? -38.673 34.255 4.152   1.00 47.75  ? 256 LEU A HD21 1 
ATOM   3919 H HD22 . LEU A 1 256 ? -38.861 35.826 4.298   1.00 47.75  ? 256 LEU A HD22 1 
ATOM   3920 H HD23 . LEU A 1 256 ? -38.619 34.932 5.588   1.00 47.75  ? 256 LEU A HD23 1 
ATOM   3921 N N    . TYR A 1 257 ? -42.309 38.475 7.033   1.00 36.80  ? 257 TYR A N    1 
ATOM   3922 C CA   . TYR A 1 257 ? -43.092 39.698 6.972   1.00 43.52  ? 257 TYR A CA   1 
ATOM   3923 C C    . TYR A 1 257 ? -42.257 40.897 7.406   1.00 35.95  ? 257 TYR A C    1 
ATOM   3924 O O    . TYR A 1 257 ? -42.222 41.926 6.726   1.00 37.11  ? 257 TYR A O    1 
ATOM   3925 C CB   . TYR A 1 257 ? -44.355 39.560 7.826   1.00 38.51  ? 257 TYR A CB   1 
ATOM   3926 C CG   . TYR A 1 257 ? -45.190 40.768 7.639   1.00 34.29  ? 257 TYR A CG   1 
ATOM   3927 C CD1  . TYR A 1 257 ? -46.105 40.840 6.586   1.00 41.60  ? 257 TYR A CD1  1 
ATOM   3928 C CD2  . TYR A 1 257 ? -45.025 41.885 8.459   1.00 40.94  ? 257 TYR A CD2  1 
ATOM   3929 C CE1  . TYR A 1 257 ? -46.902 41.978 6.398   1.00 41.64  ? 257 TYR A CE1  1 
ATOM   3930 C CE2  . TYR A 1 257 ? -45.796 43.062 8.273   1.00 41.90  ? 257 TYR A CE2  1 
ATOM   3931 C CZ   . TYR A 1 257 ? -46.727 43.114 7.241   1.00 41.73  ? 257 TYR A CZ   1 
ATOM   3932 O OH   . TYR A 1 257 ? -47.430 44.324 7.123   1.00 41.57  ? 257 TYR A OH   1 
ATOM   3933 H H    . TYR A 1 257 ? -42.599 37.870 7.572   1.00 44.21  ? 257 TYR A H    1 
ATOM   3934 H HA   . TYR A 1 257 ? -43.377 39.848 6.057   1.00 52.27  ? 257 TYR A HA   1 
ATOM   3935 H HB2  . TYR A 1 257 ? -44.859 38.780 7.549   1.00 46.26  ? 257 TYR A HB2  1 
ATOM   3936 H HB3  . TYR A 1 257 ? -44.114 39.484 8.763   1.00 46.26  ? 257 TYR A HB3  1 
ATOM   3937 H HD1  . TYR A 1 257 ? -46.188 40.122 6.001   1.00 49.97  ? 257 TYR A HD1  1 
ATOM   3938 H HD2  . TYR A 1 257 ? -44.395 41.858 9.143   1.00 49.17  ? 257 TYR A HD2  1 
ATOM   3939 H HE1  . TYR A 1 257 ? -47.543 41.992 5.724   1.00 50.02  ? 257 TYR A HE1  1 
ATOM   3940 H HE2  . TYR A 1 257 ? -45.680 43.792 8.836   1.00 50.33  ? 257 TYR A HE2  1 
ATOM   3941 H HH   . TYR A 1 257 ? -47.160 44.870 7.701   1.00 49.94  ? 257 TYR A HH   1 
ATOM   3942 N N    . TYR A 1 258 ? -41.522 40.745 8.503   1.00 38.66  ? 258 TYR A N    1 
ATOM   3943 C CA   . TYR A 1 258 ? -40.590 41.774 8.951   1.00 42.58  ? 258 TYR A CA   1 
ATOM   3944 C C    . TYR A 1 258 ? -39.484 42.026 7.912   1.00 45.15  ? 258 TYR A C    1 
ATOM   3945 O O    . TYR A 1 258 ? -39.221 43.169 7.519   1.00 40.61  ? 258 TYR A O    1 
ATOM   3946 C CB   . TYR A 1 258 ? -40.014 41.355 10.307  1.00 40.95  ? 258 TYR A CB   1 
ATOM   3947 C CG   . TYR A 1 258 ? -39.040 42.311 10.959  1.00 50.69  ? 258 TYR A CG   1 
ATOM   3948 C CD1  . TYR A 1 258 ? -39.400 43.611 11.260  1.00 53.50  ? 258 TYR A CD1  1 
ATOM   3949 C CD2  . TYR A 1 258 ? -37.747 41.893 11.261  1.00 51.93  ? 258 TYR A CD2  1 
ATOM   3950 C CE1  . TYR A 1 258 ? -38.508 44.484 11.856  1.00 51.40  ? 258 TYR A CE1  1 
ATOM   3951 C CE2  . TYR A 1 258 ? -36.848 42.746 11.850  1.00 55.03  ? 258 TYR A CE2  1 
ATOM   3952 C CZ   . TYR A 1 258 ? -37.228 44.047 12.148  1.00 60.20  ? 258 TYR A CZ   1 
ATOM   3953 O OH   . TYR A 1 258 ? -36.308 44.889 12.738  1.00 64.99  ? 258 TYR A OH   1 
ATOM   3954 N N    . VAL A 1 259 ? -38.817 40.965 7.456   1.00 40.68  ? 259 VAL A N    1 
ATOM   3955 C CA   . VAL A 1 259 ? -37.822 41.138 6.400   1.00 42.76  ? 259 VAL A CA   1 
ATOM   3956 C C    . VAL A 1 259 ? -38.407 41.963 5.261   1.00 44.05  ? 259 VAL A C    1 
ATOM   3957 O O    . VAL A 1 259 ? -37.849 42.992 4.854   1.00 35.21  ? 259 VAL A O    1 
ATOM   3958 C CB   . VAL A 1 259 ? -37.334 39.765 5.904   1.00 38.86  ? 259 VAL A CB   1 
ATOM   3959 C CG1  . VAL A 1 259 ? -36.518 39.930 4.657   1.00 33.37  ? 259 VAL A CG1  1 
ATOM   3960 C CG2  . VAL A 1 259 ? -36.528 39.095 6.968   1.00 44.93  ? 259 VAL A CG2  1 
ATOM   3961 H H    . VAL A 1 259 ? -38.920 40.157 7.733   1.00 48.87  ? 259 VAL A H    1 
ATOM   3962 H HA   . VAL A 1 259 ? -37.061 41.618 6.761   1.00 51.36  ? 259 VAL A HA   1 
ATOM   3963 H HB   . VAL A 1 259 ? -38.099 39.205 5.699   1.00 46.68  ? 259 VAL A HB   1 
ATOM   3964 H HG11 . VAL A 1 259 ? -36.147 39.069 4.406   1.00 40.10  ? 259 VAL A HG11 1 
ATOM   3965 H HG12 . VAL A 1 259 ? -37.089 40.264 3.948   1.00 40.10  ? 259 VAL A HG12 1 
ATOM   3966 H HG13 . VAL A 1 259 ? -35.801 40.561 4.830   1.00 40.10  ? 259 VAL A HG13 1 
ATOM   3967 H HG21 . VAL A 1 259 ? -35.898 39.735 7.336   1.00 53.97  ? 259 VAL A HG21 1 
ATOM   3968 H HG22 . VAL A 1 259 ? -37.125 38.780 7.665   1.00 53.97  ? 259 VAL A HG22 1 
ATOM   3969 H HG23 . VAL A 1 259 ? -36.050 38.347 6.578   1.00 53.97  ? 259 VAL A HG23 1 
ATOM   3970 N N    . HIS A 1 260 ? -39.543 41.515 4.698   1.00 36.76  ? 260 HIS A N    1 
ATOM   3971 C CA   . HIS A 1 260 ? -40.092 42.204 3.543   1.00 34.69  ? 260 HIS A CA   1 
ATOM   3972 C C    . HIS A 1 260 ? -40.573 43.628 3.875   1.00 41.81  ? 260 HIS A C    1 
ATOM   3973 O O    . HIS A 1 260 ? -40.516 44.514 3.005   1.00 34.25  ? 260 HIS A O    1 
ATOM   3974 C CB   . HIS A 1 260 ? -41.248 41.390 2.964   1.00 40.44  ? 260 HIS A CB   1 
ATOM   3975 C CG   . HIS A 1 260 ? -40.864 40.038 2.464   1.00 39.93  ? 260 HIS A CG   1 
ATOM   3976 N ND1  . HIS A 1 260 ? -41.784 39.021 2.320   1.00 33.99  ? 260 HIS A ND1  1 
ATOM   3977 C CD2  . HIS A 1 260 ? -39.674 39.546 2.040   1.00 36.89  ? 260 HIS A CD2  1 
ATOM   3978 C CE1  . HIS A 1 260 ? -41.170 37.953 1.837   1.00 41.56  ? 260 HIS A CE1  1 
ATOM   3979 N NE2  . HIS A 1 260 ? -39.891 38.244 1.660   1.00 42.55  ? 260 HIS A NE2  1 
ATOM   3980 H H    . HIS A 1 260 ? -39.994 40.833 4.965   1.00 44.17  ? 260 HIS A H    1 
ATOM   3981 H HA   . HIS A 1 260 ? -39.392 42.282 2.876   1.00 41.68  ? 260 HIS A HA   1 
ATOM   3982 H HB2  . HIS A 1 260 ? -41.917 41.267 3.655   1.00 48.57  ? 260 HIS A HB2  1 
ATOM   3983 H HB3  . HIS A 1 260 ? -41.629 41.880 2.218   1.00 48.57  ? 260 HIS A HB3  1 
ATOM   3984 H HD2  . HIS A 1 260 ? -38.864 40.003 2.012   1.00 44.32  ? 260 HIS A HD2  1 
ATOM   3985 H HE1  . HIS A 1 260 ? -41.570 37.134 1.653   1.00 49.93  ? 260 HIS A HE1  1 
ATOM   3986 H HE2  . HIS A 1 260 ? -39.294 37.705 1.356   1.00 51.11  ? 260 HIS A HE2  1 
ATOM   3987 N N    . SER A 1 261 ? -41.070 43.862 5.103   1.00 32.12  ? 261 SER A N    1 
ATOM   3988 C CA   . SER A 1 261 ? -41.415 45.217 5.520   1.00 42.07  ? 261 SER A CA   1 
ATOM   3989 C C    . SER A 1 261 ? -40.174 46.128 5.560   1.00 41.93  ? 261 SER A C    1 
ATOM   3990 O O    . SER A 1 261 ? -40.232 47.292 5.149   1.00 32.55  ? 261 SER A O    1 
ATOM   3991 C CB   . SER A 1 261 ? -42.117 45.164 6.886   1.00 43.91  ? 261 SER A CB   1 
ATOM   3992 O OG   . SER A 1 261 ? -43.421 44.533 6.837   1.00 40.94  ? 261 SER A OG   1 
ATOM   3993 H H    . SER A 1 261 ? -41.212 43.259 5.699   1.00 38.60  ? 261 SER A H    1 
ATOM   3994 H HA   . SER A 1 261 ? -42.031 45.606 4.879   1.00 50.54  ? 261 SER A HA   1 
ATOM   3995 H HB2  . SER A 1 261 ? -41.557 44.661 7.498   1.00 52.74  ? 261 SER A HB2  1 
ATOM   3996 H HB3  . SER A 1 261 ? -42.229 46.072 7.208   1.00 52.74  ? 261 SER A HB3  1 
ATOM   3997 H HG   . SER A 1 261 ? -43.572 44.128 7.558   1.00 49.18  ? 261 SER A HG   1 
ATOM   3998 N N    . LEU A 1 262 ? -39.041 45.641 6.061   1.00 45.23  ? 262 LEU A N    1 
ATOM   3999 C CA   . LEU A 1 262 ? -37.862 46.510 6.044   1.00 41.55  ? 262 LEU A CA   1 
ATOM   4000 C C    . LEU A 1 262 ? -37.477 46.865 4.618   1.00 43.89  ? 262 LEU A C    1 
ATOM   4001 O O    . LEU A 1 262 ? -37.234 48.036 4.288   1.00 44.37  ? 262 LEU A O    1 
ATOM   4002 C CB   . LEU A 1 262 ? -36.705 45.837 6.754   1.00 42.14  ? 262 LEU A CB   1 
ATOM   4003 C CG   . LEU A 1 262 ? -37.032 45.574 8.194   1.00 42.20  ? 262 LEU A CG   1 
ATOM   4004 C CD1  . LEU A 1 262 ? -35.951 44.663 8.743   1.00 45.42  ? 262 LEU A CD1  1 
ATOM   4005 C CD2  . LEU A 1 262 ? -37.115 46.864 8.973   1.00 48.60  ? 262 LEU A CD2  1 
ATOM   4006 H H    . LEU A 1 262 ? -38.933 44.858 6.398   1.00 54.32  ? 262 LEU A H    1 
ATOM   4007 H HA   . LEU A 1 262 ? -38.069 47.329 6.520   1.00 49.91  ? 262 LEU A HA   1 
ATOM   4008 H HB2  . LEU A 1 262 ? -36.513 44.990 6.323   1.00 50.62  ? 262 LEU A HB2  1 
ATOM   4009 H HB3  . LEU A 1 262 ? -35.926 46.413 6.716   1.00 50.62  ? 262 LEU A HB3  1 
ATOM   4010 H HG   . LEU A 1 262 ? -37.898 45.148 8.285   1.00 50.69  ? 262 LEU A HG   1 
ATOM   4011 H HD11 . LEU A 1 262 ? -35.976 44.691 9.712   1.00 54.56  ? 262 LEU A HD11 1 
ATOM   4012 H HD12 . LEU A 1 262 ? -35.087 44.971 8.426   1.00 54.56  ? 262 LEU A HD12 1 
ATOM   4013 H HD13 . LEU A 1 262 ? -36.113 43.758 8.434   1.00 54.56  ? 262 LEU A HD13 1 
ATOM   4014 H HD21 . LEU A 1 262 ? -36.956 46.677 9.911   1.00 58.37  ? 262 LEU A HD21 1 
ATOM   4015 H HD22 . LEU A 1 262 ? -36.442 47.478 8.639   1.00 58.37  ? 262 LEU A HD22 1 
ATOM   4016 H HD23 . LEU A 1 262 ? -37.999 47.246 8.856   1.00 58.37  ? 262 LEU A HD23 1 
ATOM   4017 N N    . LEU A 1 263 ? -37.399 45.844 3.762   1.00 37.24  ? 263 LEU A N    1 
ATOM   4018 C CA   . LEU A 1 263 ? -37.167 46.033 2.336   1.00 42.82  ? 263 LEU A CA   1 
ATOM   4019 C C    . LEU A 1 263 ? -38.152 47.017 1.705   1.00 39.19  ? 263 LEU A C    1 
ATOM   4020 O O    . LEU A 1 263 ? -37.755 47.881 0.921   1.00 33.25  ? 263 LEU A O    1 
ATOM   4021 C CB   . LEU A 1 263 ? -37.268 44.688 1.615   1.00 39.52  ? 263 LEU A CB   1 
ATOM   4022 C CG   . LEU A 1 263 ? -37.016 44.598 0.115   1.00 36.64  ? 263 LEU A CG   1 
ATOM   4023 C CD1  . LEU A 1 263 ? -35.658 45.294 -0.088  1.00 40.45  ? 263 LEU A CD1  1 
ATOM   4024 C CD2  . LEU A 1 263 ? -37.095 43.154 -0.350  1.00 36.68  ? 263 LEU A CD2  1 
ATOM   4025 H H    . LEU A 1 263 ? -37.479 45.018 3.988   1.00 44.74  ? 263 LEU A H    1 
ATOM   4026 H HA   . LEU A 1 263 ? -36.274 46.397 2.232   1.00 51.43  ? 263 LEU A HA   1 
ATOM   4027 H HB2  . LEU A 1 263 ? -36.626 44.092 2.032   1.00 47.48  ? 263 LEU A HB2  1 
ATOM   4028 H HB3  . LEU A 1 263 ? -38.169 44.356 1.756   1.00 47.48  ? 263 LEU A HB3  1 
ATOM   4029 H HG   . LEU A 1 263 ? -37.678 45.037 -0.441  1.00 44.02  ? 263 LEU A HG   1 
ATOM   4030 H HD11 . LEU A 1 263 ? -35.802 46.249 -0.175  1.00 48.60  ? 263 LEU A HD11 1 
ATOM   4031 H HD12 . LEU A 1 263 ? -35.242 44.948 -0.893  1.00 48.60  ? 263 LEU A HD12 1 
ATOM   4032 H HD13 . LEU A 1 263 ? -35.093 45.114 0.680   1.00 48.60  ? 263 LEU A HD13 1 
ATOM   4033 H HD21 . LEU A 1 263 ? -36.864 43.112 -1.291  1.00 44.07  ? 263 LEU A HD21 1 
ATOM   4034 H HD22 . LEU A 1 263 ? -36.472 42.620 0.168   1.00 44.07  ? 263 LEU A HD22 1 
ATOM   4035 H HD23 . LEU A 1 263 ? -37.999 42.828 -0.217  1.00 44.07  ? 263 LEU A HD23 1 
ATOM   4036 N N    . TYR A 1 264 ? -39.450 46.845 1.934   1.00 36.24  ? 264 TYR A N    1 
ATOM   4037 C CA   . TYR A 1 264 ? -40.380 47.774 1.286   1.00 43.02  ? 264 TYR A CA   1 
ATOM   4038 C C    . TYR A 1 264 ? -40.191 49.198 1.805   1.00 39.86  ? 264 TYR A C    1 
ATOM   4039 O O    . TYR A 1 264 ? -40.228 50.156 1.032   1.00 39.02  ? 264 TYR A O    1 
ATOM   4040 C CB   . TYR A 1 264 ? -41.831 47.354 1.504   1.00 34.85  ? 264 TYR A CB   1 
ATOM   4041 C CG   . TYR A 1 264 ? -42.821 48.036 0.604   1.00 39.51  ? 264 TYR A CG   1 
ATOM   4042 C CD1  . TYR A 1 264 ? -42.741 47.898 -0.760  1.00 43.18  ? 264 TYR A CD1  1 
ATOM   4043 C CD2  . TYR A 1 264 ? -43.888 48.754 1.110   1.00 45.52  ? 264 TYR A CD2  1 
ATOM   4044 C CE1  . TYR A 1 264 ? -43.665 48.456 -1.597  1.00 46.25  ? 264 TYR A CE1  1 
ATOM   4045 C CE2  . TYR A 1 264 ? -44.838 49.323 0.261   1.00 40.97  ? 264 TYR A CE2  1 
ATOM   4046 C CZ   . TYR A 1 264 ? -44.702 49.195 -1.096  1.00 49.26  ? 264 TYR A CZ   1 
ATOM   4047 O OH   . TYR A 1 264 ? -45.610 49.753 -1.988  1.00 52.46  ? 264 TYR A OH   1 
ATOM   4048 H H    . TYR A 1 264 ? -39.801 46.236 2.429   1.00 43.54  ? 264 TYR A H    1 
ATOM   4049 H HA   . TYR A 1 264 ? -40.195 47.747 0.334   1.00 51.67  ? 264 TYR A HA   1 
ATOM   4050 H HB2  . TYR A 1 264 ? -41.903 46.400 1.348   1.00 41.87  ? 264 TYR A HB2  1 
ATOM   4051 H HB3  . TYR A 1 264 ? -42.078 47.560 2.419   1.00 41.87  ? 264 TYR A HB3  1 
ATOM   4052 H HD1  . TYR A 1 264 ? -42.038 47.409 -1.124  1.00 51.87  ? 264 TYR A HD1  1 
ATOM   4053 H HD2  . TYR A 1 264 ? -43.975 48.859 2.030   1.00 54.68  ? 264 TYR A HD2  1 
ATOM   4054 H HE1  . TYR A 1 264 ? -43.588 48.333 -2.516  1.00 55.55  ? 264 TYR A HE1  1 
ATOM   4055 H HE2  . TYR A 1 264 ? -45.560 49.789 0.615   1.00 49.21  ? 264 TYR A HE2  1 
ATOM   4056 H HH   . TYR A 1 264 ? -46.212 50.161 -1.567  1.00 63.00  ? 264 TYR A HH   1 
ATOM   4057 N N    . SER A 1 265 ? -40.076 49.347 3.127   1.00 43.22  ? 265 SER A N    1 
ATOM   4058 C CA   . SER A 1 265 ? -39.825 50.659 3.713   1.00 47.40  ? 265 SER A CA   1 
ATOM   4059 C C    . SER A 1 265 ? -38.560 51.273 3.116   1.00 51.71  ? 265 SER A C    1 
ATOM   4060 O O    . SER A 1 265 ? -38.527 52.459 2.776   1.00 48.50  ? 265 SER A O    1 
ATOM   4061 C CB   . SER A 1 265 ? -39.696 50.550 5.241   1.00 46.54  ? 265 SER A CB   1 
ATOM   4062 O OG   . SER A 1 265 ? -40.922 50.173 5.880   1.00 43.56  ? 265 SER A OG   1 
ATOM   4063 H H    . SER A 1 265 ? -40.138 48.708 3.700   1.00 51.91  ? 265 SER A H    1 
ATOM   4064 H HA   . SER A 1 265 ? -40.578 51.240 3.524   1.00 56.93  ? 265 SER A HA   1 
ATOM   4065 H HB2  . SER A 1 265 ? -39.024 49.881 5.446   1.00 55.90  ? 265 SER A HB2  1 
ATOM   4066 H HB3  . SER A 1 265 ? -39.421 51.413 5.589   1.00 55.90  ? 265 SER A HB3  1 
ATOM   4067 H HG   . SER A 1 265 ? -41.224 49.471 5.530   1.00 52.32  ? 265 SER A HG   1 
ATOM   4068 N N    . SER A 1 266 ? -37.499 50.485 2.983   1.00 47.80  ? 266 SER A N    1 
ATOM   4069 C CA   . SER A 1 266 ? -36.283 51.016 2.388   1.00 47.95  ? 266 SER A CA   1 
ATOM   4070 C C    . SER A 1 266 ? -36.548 51.472 0.960   1.00 51.34  ? 266 SER A C    1 
ATOM   4071 O O    . SER A 1 266 ? -36.271 52.627 0.594   1.00 46.33  ? 266 SER A O    1 
ATOM   4072 C CB   . SER A 1 266 ? -35.189 49.949 2.458   1.00 50.89  ? 266 SER A CB   1 
ATOM   4073 O OG   . SER A 1 266 ? -34.122 50.202 1.576   1.00 49.37  ? 266 SER A OG   1 
ATOM   4074 H H    . SER A 1 266 ? -37.460 49.660 3.223   1.00 57.41  ? 266 SER A H    1 
ATOM   4075 H HA   . SER A 1 266 ? -35.971 51.788 2.885   1.00 57.59  ? 266 SER A HA   1 
ATOM   4076 H HB2  . SER A 1 266 ? -34.840 49.925 3.363   1.00 61.12  ? 266 SER A HB2  1 
ATOM   4077 H HB3  . SER A 1 266 ? -35.580 49.091 2.231   1.00 61.12  ? 266 SER A HB3  1 
ATOM   4078 H HG   . SER A 1 266 ? -33.556 49.583 1.624   1.00 59.30  ? 266 SER A HG   1 
ATOM   4079 N N    . MET A 1 267 ? -37.140 50.589 0.153   1.00 46.21  ? 267 MET A N    1 
ATOM   4080 C CA   . MET A 1 267 ? -37.392 50.912 -1.240  1.00 43.37  ? 267 MET A CA   1 
ATOM   4081 C C    . MET A 1 267 ? -38.362 52.062 -1.399  1.00 47.98  ? 267 MET A C    1 
ATOM   4082 O O    . MET A 1 267 ? -38.459 52.617 -2.497  1.00 54.25  ? 267 MET A O    1 
ATOM   4083 C CB   . MET A 1 267 ? -37.938 49.703 -2.004  1.00 44.95  ? 267 MET A CB   1 
ATOM   4084 C CG   . MET A 1 267 ? -36.982 48.532 -2.131  1.00 45.50  ? 267 MET A CG   1 
ATOM   4085 S SD   . MET A 1 267 ? -37.830 47.097 -2.865  1.00 40.30  ? 267 MET A SD   1 
ATOM   4086 C CE   . MET A 1 267 ? -37.931 47.503 -4.584  1.00 41.04  ? 267 MET A CE   1 
ATOM   4087 H H    . MET A 1 267 ? -37.400 49.804 0.390   1.00 55.50  ? 267 MET A H    1 
ATOM   4088 H HA   . MET A 1 267 ? -36.537 51.147 -1.632  1.00 52.09  ? 267 MET A HA   1 
ATOM   4089 H HB2  . MET A 1 267 ? -38.730 49.383 -1.543  1.00 53.99  ? 267 MET A HB2  1 
ATOM   4090 H HB3  . MET A 1 267 ? -38.170 49.988 -2.902  1.00 53.99  ? 267 MET A HB3  1 
ATOM   4091 H HG2  . MET A 1 267 ? -36.240 48.780 -2.705  1.00 54.65  ? 267 MET A HG2  1 
ATOM   4092 H HG3  . MET A 1 267 ? -36.654 48.283 -1.253  1.00 54.65  ? 267 MET A HG3  1 
ATOM   4093 H HE1  . MET A 1 267 ? -38.372 46.779 -5.054  1.00 49.29  ? 267 MET A HE1  1 
ATOM   4094 H HE2  . MET A 1 267 ? -38.440 48.322 -4.685  1.00 49.29  ? 267 MET A HE2  1 
ATOM   4095 H HE3  . MET A 1 267 ? -37.034 47.626 -4.932  1.00 49.29  ? 267 MET A HE3  1 
ATOM   4096 N N    . THR A 1 268 ? -39.121 52.404 -0.356  1.00 52.72  ? 268 THR A N    1 
ATOM   4097 C CA   . THR A 1 268 ? -40.051 53.531 -0.420  1.00 56.06  ? 268 THR A CA   1 
ATOM   4098 C C    . THR A 1 268 ? -39.637 54.688 0.502   1.00 53.02  ? 268 THR A C    1 
ATOM   4099 O O    . THR A 1 268 ? -40.474 55.536 0.842   1.00 53.02  ? 268 THR A O    1 
ATOM   4100 C CB   . THR A 1 268 ? -41.492 53.084 -0.087  1.00 45.63  ? 268 THR A CB   1 
ATOM   4101 O OG1  . THR A 1 268 ? -41.569 52.512 1.231   1.00 49.56  ? 268 THR A OG1  1 
ATOM   4102 C CG2  . THR A 1 268 ? -42.008 52.063 -1.068  1.00 47.06  ? 268 THR A CG2  1 
ATOM   4103 H H    . THR A 1 268 ? -39.115 51.996 0.401   1.00 63.31  ? 268 THR A H    1 
ATOM   4104 H HA   . THR A 1 268 ? -40.047 53.860 -1.332  1.00 67.33  ? 268 THR A HA   1 
ATOM   4105 H HB   . THR A 1 268 ? -42.051 53.875 -0.135  1.00 54.81  ? 268 THR A HB   1 
ATOM   4106 H HG1  . THR A 1 268 ? -41.573 53.121 1.809   1.00 59.52  ? 268 THR A HG1  1 
ATOM   4107 H HG21 . THR A 1 268 ? -41.446 51.273 -1.050  1.00 56.52  ? 268 THR A HG21 1 
ATOM   4108 H HG22 . THR A 1 268 ? -42.915 51.810 -0.836  1.00 56.52  ? 268 THR A HG22 1 
ATOM   4109 H HG23 . THR A 1 268 ? -42.003 52.433 -1.964  1.00 56.52  ? 268 THR A HG23 1 
ATOM   4110 N N    . SER A 1 269 ? -38.369 54.743 0.921   1.00 54.85  ? 269 SER A N    1 
ATOM   4111 C CA   . SER A 1 269 ? -37.957 55.733 1.915   1.00 61.36  ? 269 SER A CA   1 
ATOM   4112 C C    . SER A 1 269 ? -38.067 57.148 1.346   1.00 67.28  ? 269 SER A C    1 
ATOM   4113 O O    . SER A 1 269 ? -37.921 57.376 0.130   1.00 50.78  ? 269 SER A O    1 
ATOM   4114 C CB   . SER A 1 269 ? -36.513 55.483 2.372   1.00 61.94  ? 269 SER A CB   1 
ATOM   4115 O OG   . SER A 1 269 ? -36.213 56.172 3.585   1.00 72.14  ? 269 SER A OG   1 
ATOM   4116 H H    . SER A 1 269 ? -37.739 54.224 0.649   1.00 65.88  ? 269 SER A H    1 
ATOM   4117 H HA   . SER A 1 269 ? -38.538 55.659 2.689   1.00 73.68  ? 269 SER A HA   1 
ATOM   4118 H HB2  . SER A 1 269 ? -36.392 54.532 2.516   1.00 74.38  ? 269 SER A HB2  1 
ATOM   4119 H HB3  . SER A 1 269 ? -35.909 55.794 1.680   1.00 74.38  ? 269 SER A HB3  1 
ATOM   4120 H HG   . SER A 1 269 ? -35.398 56.083 3.772   1.00 86.61  ? 269 SER A HG   1 
ATOM   4121 N N    . ASP A 1 270 ? -38.338 58.101 2.251   1.00 66.78  ? 270 ASP A N    1 
ATOM   4122 C CA   . ASP A 1 270 ? -38.293 59.515 1.879   1.00 71.93  ? 270 ASP A CA   1 
ATOM   4123 C C    . ASP A 1 270 ? -36.914 59.887 1.358   1.00 70.21  ? 270 ASP A C    1 
ATOM   4124 O O    . ASP A 1 270 ? -36.790 60.587 0.348   1.00 76.00  ? 270 ASP A O    1 
ATOM   4125 C CB   . ASP A 1 270 ? -38.652 60.387 3.078   1.00 64.87  ? 270 ASP A CB   1 
ATOM   4126 C CG   . ASP A 1 270 ? -40.138 60.434 3.344   1.00 82.37  ? 270 ASP A CG   1 
ATOM   4127 O OD1  . ASP A 1 270 ? -40.929 60.166 2.415   1.00 66.34  ? 270 ASP A OD1  1 
ATOM   4128 O OD2  . ASP A 1 270 ? -40.520 60.738 4.494   1.00 76.63  ? 270 ASP A OD2  1 
ATOM   4129 H H    . ASP A 1 270 ? -38.548 57.954 3.072   1.00 80.18  ? 270 ASP A H    1 
ATOM   4130 H HA   . ASP A 1 270 ? -38.946 59.679 1.181   1.00 86.36  ? 270 ASP A HA   1 
ATOM   4131 H HB2  . ASP A 1 270 ? -38.217 60.032 3.868   1.00 77.89  ? 270 ASP A HB2  1 
ATOM   4132 H HB3  . ASP A 1 270 ? -38.349 61.294 2.911   1.00 77.89  ? 270 ASP A HB3  1 
ATOM   4133 N N    . SER A 1 271 ? -35.865 59.416 2.036   1.00 74.56  ? 271 SER A N    1 
ATOM   4134 C CA   . SER A 1 271 ? -34.485 59.550 1.575   1.00 75.39  ? 271 SER A CA   1 
ATOM   4135 C C    . SER A 1 271 ? -34.377 59.294 0.076   1.00 74.88  ? 271 SER A C    1 
ATOM   4136 O O    . SER A 1 271 ? -33.514 59.854 -0.603  1.00 75.50  ? 271 SER A O    1 
ATOM   4137 C CB   . SER A 1 271 ? -33.569 58.559 2.317   1.00 76.14  ? 271 SER A CB   1 
ATOM   4138 O OG   . SER A 1 271 ? -33.464 58.838 3.712   1.00 84.39  ? 271 SER A OG   1 
ATOM   4139 H H    . SER A 1 271 ? -35.930 59.003 2.787   1.00 89.52  ? 271 SER A H    1 
ATOM   4140 H HA   . SER A 1 271 ? -34.191 60.455 1.761   1.00 90.52  ? 271 SER A HA   1 
ATOM   4141 H HB2  . SER A 1 271 ? -33.930 57.666 2.208   1.00 91.42  ? 271 SER A HB2  1 
ATOM   4142 H HB3  . SER A 1 271 ? -32.682 58.609 1.927   1.00 91.42  ? 271 SER A HB3  1 
ATOM   4143 H HG   . SER A 1 271 ? -32.884 58.341 4.061   1.00 101.31 ? 271 SER A HG   1 
ATOM   4144 N N    . LYS A 1 272 ? -35.230 58.421 -0.450  1.00 77.97  ? 272 LYS A N    1 
ATOM   4145 C CA   . LYS A 1 272 ? -35.189 58.058 -1.864  1.00 74.28  ? 272 LYS A CA   1 
ATOM   4146 C C    . LYS A 1 272 ? -33.795 57.589 -2.270  1.00 72.46  ? 272 LYS A C    1 
ATOM   4147 O O    . LYS A 1 272 ? -33.366 57.794 -3.408  1.00 69.30  ? 272 LYS A O    1 
ATOM   4148 C CB   . LYS A 1 272 ? -35.645 59.222 -2.746  1.00 76.81  ? 272 LYS A CB   1 
ATOM   4149 C CG   . LYS A 1 272 ? -36.090 58.801 -4.147  1.00 79.71  ? 272 LYS A CG   1 
ATOM   4150 C CD   . LYS A 1 272 ? -36.771 59.937 -4.920  1.00 74.22  ? 272 LYS A CD   1 
ATOM   4151 C CE   . LYS A 1 272 ? -38.161 60.252 -4.360  1.00 82.34  ? 272 LYS A CE   1 
ATOM   4152 N NZ   . LYS A 1 272 ? -39.231 59.305 -4.823  1.00 80.09  ? 272 LYS A NZ   1 
ATOM   4153 H H    . LYS A 1 272 ? -35.849 58.022 -0.006  1.00 93.61  ? 272 LYS A H    1 
ATOM   4154 H HA   . LYS A 1 272 ? -35.800 57.319 -2.008  1.00 89.19  ? 272 LYS A HA   1 
ATOM   4155 H HB2  . LYS A 1 272 ? -36.396 59.662 -2.318  1.00 92.22  ? 272 LYS A HB2  1 
ATOM   4156 H HB3  . LYS A 1 272 ? -34.908 59.845 -2.845  1.00 92.22  ? 272 LYS A HB3  1 
ATOM   4157 H HG2  . LYS A 1 272 ? -35.313 58.518 -4.654  1.00 95.71  ? 272 LYS A HG2  1 
ATOM   4158 H HG3  . LYS A 1 272 ? -36.722 58.069 -4.071  1.00 95.71  ? 272 LYS A HG3  1 
ATOM   4159 H HD2  . LYS A 1 272 ? -36.229 60.739 -4.855  1.00 89.11  ? 272 LYS A HD2  1 
ATOM   4160 H HD3  . LYS A 1 272 ? -36.869 59.678 -5.850  1.00 89.11  ? 272 LYS A HD3  1 
ATOM   4161 H HE2  . LYS A 1 272 ? -38.125 60.206 -3.392  1.00 98.85  ? 272 LYS A HE2  1 
ATOM   4162 H HE3  . LYS A 1 272 ? -38.416 61.145 -4.640  1.00 98.85  ? 272 LYS A HE3  1 
ATOM   4163 H HZ1  . LYS A 1 272 ? -39.297 59.331 -5.710  1.00 96.16  ? 272 LYS A HZ1  1 
ATOM   4164 H HZ2  . LYS A 1 272 ? -40.014 59.533 -4.468  1.00 96.16  ? 272 LYS A HZ2  1 
ATOM   4165 H HZ3  . LYS A 1 272 ? -39.032 58.474 -4.573  1.00 96.16  ? 272 LYS A HZ3  1 
ATOM   4166 N N    . SER A 1 273 ? -33.074 56.954 -1.344  1.00 99.57  ? 273 SER A N    1 
ATOM   4167 C CA   . SER A 1 273 ? -31.793 56.339 -1.671  1.00 83.82  ? 273 SER A CA   1 
ATOM   4168 C C    . SER A 1 273 ? -31.689 54.980 -0.984  1.00 70.53  ? 273 SER A C    1 
ATOM   4169 O O    . SER A 1 273 ? -32.568 54.560 -0.235  1.00 63.24  ? 273 SER A O    1 
ATOM   4170 C CB   . SER A 1 273 ? -30.606 57.220 -1.244  1.00 82.41  ? 273 SER A CB   1 
ATOM   4171 O OG   . SER A 1 273 ? -30.323 57.112 0.150   1.00 76.26  ? 273 SER A OG   1 
ATOM   4172 H H    . SER A 1 273 ? -33.309 56.868 -0.521  1.00 119.53 ? 273 SER A H    1 
ATOM   4173 H HA   . SER A 1 273 ? -31.770 56.216 -2.632  1.00 100.64 ? 273 SER A HA   1 
ATOM   4174 H HB2  . SER A 1 273 ? -29.821 56.943 -1.742  1.00 98.94  ? 273 SER A HB2  1 
ATOM   4175 H HB3  . SER A 1 273 ? -30.819 58.145 -1.447  1.00 98.94  ? 273 SER A HB3  1 
ATOM   4176 H HG   . SER A 1 273 ? -29.547 57.391 0.308   1.00 91.57  ? 273 SER A HG   1 
ATOM   4177 N N    . ILE A 1 274 ? -30.659 54.216 -1.318  1.00 66.61  ? 274 ILE A N    1 
ATOM   4178 C CA   . ILE A 1 274 ? -30.424 52.862 -0.756  1.00 65.54  ? 274 ILE A CA   1 
ATOM   4179 C C    . ILE A 1 274 ? -29.717 52.992 0.576   1.00 68.83  ? 274 ILE A C    1 
ATOM   4180 O O    . ILE A 1 274 ? -29.436 51.974 1.168   1.00 66.76  ? 274 ILE A O    1 
ATOM   4181 C CB   . ILE A 1 274 ? -29.589 52.009 -1.723  1.00 74.50  ? 274 ILE A CB   1 
ATOM   4182 C CG1  . ILE A 1 274 ? -29.826 50.516 -1.504  1.00 62.98  ? 274 ILE A CG1  1 
ATOM   4183 C CG2  . ILE A 1 274 ? -28.111 52.359 -1.639  1.00 63.48  ? 274 ILE A CG2  1 
ATOM   4184 C CD1  . ILE A 1 274 ? -29.859 49.731 -2.778  1.00 61.61  ? 274 ILE A CD1  1 
ATOM   4185 H H    . ILE A 1 274 ? -30.023 54.467 -1.924  1.00 79.98  ? 274 ILE A H    1 
ATOM   4186 H HA   . ILE A 1 274 ? -31.279 52.422 -0.617  1.00 78.70  ? 274 ILE A HA   1 
ATOM   4187 H HB   . ILE A 1 274 ? -29.895 52.222 -2.637  1.00 89.44  ? 274 ILE A HB   1 
ATOM   4188 H HG12 . ILE A 1 274 ? -29.113 50.163 -0.932  1.00 75.63  ? 274 ILE A HG12 1 
ATOM   4189 H HG13 . ILE A 1 274 ? -30.679 50.395 -1.035  1.00 75.63  ? 274 ILE A HG13 1 
ATOM   4190 H HG21 . ILE A 1 274 ? -28.007 53.317 -1.504  1.00 76.23  ? 274 ILE A HG21 1 
ATOM   4191 H HG22 . ILE A 1 274 ? -27.674 52.103 -2.469  1.00 76.23  ? 274 ILE A HG22 1 
ATOM   4192 H HG23 . ILE A 1 274 ? -27.700 51.879 -0.900  1.00 76.23  ? 274 ILE A HG23 1 
ATOM   4193 H HD11 . ILE A 1 274 ? -29.695 48.792 -2.586  1.00 73.98  ? 274 ILE A HD11 1 
ATOM   4194 H HD12 . ILE A 1 274 ? -30.732 49.826 -3.197  1.00 73.98  ? 274 ILE A HD12 1 
ATOM   4195 H HD13 . ILE A 1 274 ? -29.174 50.062 -3.383  1.00 73.98  ? 274 ILE A HD13 1 
ATOM   4196 N N    . GLU A 1 275 ? -29.365 54.195 0.974   1.00 68.07  ? 275 GLU A N    1 
ATOM   4197 C CA   . GLU A 1 275 ? -28.777 54.427 2.308   1.00 68.10  ? 275 GLU A CA   1 
ATOM   4198 C C    . GLU A 1 275 ? -29.884 55.052 3.122   1.00 63.60  ? 275 GLU A C    1 
ATOM   4199 O O    . GLU A 1 275 ? -30.156 56.232 2.935   1.00 70.46  ? 275 GLU A O    1 
ATOM   4200 C CB   . GLU A 1 275 ? -27.523 55.295 2.259   1.00 30.00  ? 275 GLU A CB   1 
ATOM   4201 H H    . GLU A 1 275 ? -29.428 54.938 0.455   1.00 81.74  ? 275 GLU A H    1 
ATOM   4202 H HA   . GLU A 1 275 ? -28.542 53.566 2.714   1.00 81.78  ? 275 GLU A HA   1 
ATOM   4203 N N    . ASN A 1 276 ? -30.512 54.246 3.953   1.00 66.64  ? 276 ASN A N    1 
ATOM   4204 C CA   . ASN A 1 276 ? -31.589 54.726 4.827   1.00 65.98  ? 276 ASN A CA   1 
ATOM   4205 C C    . ASN A 1 276 ? -31.577 53.843 6.056   1.00 59.10  ? 276 ASN A C    1 
ATOM   4206 O O    . ASN A 1 276 ? -30.877 52.862 6.039   1.00 56.24  ? 276 ASN A O    1 
ATOM   4207 C CB   . ASN A 1 276 ? -32.908 54.776 4.062   1.00 59.54  ? 276 ASN A CB   1 
ATOM   4208 C CG   . ASN A 1 276 ? -33.383 53.445 3.544   1.00 58.88  ? 276 ASN A CG   1 
ATOM   4209 O OD1  . ASN A 1 276 ? -34.177 52.797 4.202   1.00 50.97  ? 276 ASN A OD1  1 
ATOM   4210 N ND2  . ASN A 1 276 ? -32.970 53.074 2.348   1.00 54.22  ? 276 ASN A ND2  1 
ATOM   4211 H H    . ASN A 1 276 ? -30.329 53.356 4.025   1.00 80.02  ? 276 ASN A H    1 
ATOM   4212 H HA   . ASN A 1 276 ? -31.374 55.644 5.108   1.00 79.23  ? 276 ASN A HA   1 
ATOM   4213 H HB2  . ASN A 1 276 ? -33.594 55.142 4.655   1.00 71.49  ? 276 ASN A HB2  1 
ATOM   4214 H HB3  . ASN A 1 276 ? -32.809 55.391 3.307   1.00 71.49  ? 276 ASN A HB3  1 
ATOM   4215 H HD21 . ASN A 1 276 ? -33.207 52.286 2.022   1.00 65.11  ? 276 ASN A HD21 1 
ATOM   4216 H HD22 . ASN A 1 276 ? -32.451 53.611 1.872   1.00 65.11  ? 276 ASN A HD22 1 
ATOM   4217 N N    . LYS A 1 277 ? -32.284 54.244 7.086   1.00 56.24  ? 277 LYS A N    1 
ATOM   4218 C CA   . LYS A 1 277 ? -32.364 53.484 8.346   1.00 55.82  ? 277 LYS A CA   1 
ATOM   4219 C C    . LYS A 1 277 ? -32.961 52.095 8.107   1.00 57.17  ? 277 LYS A C    1 
ATOM   4220 O O    . LYS A 1 277 ? -32.560 51.211 8.814   1.00 53.17  ? 277 LYS A O    1 
ATOM   4221 C CB   . LYS A 1 277 ? -33.201 54.263 9.350   1.00 56.54  ? 277 LYS A CB   1 
ATOM   4222 C CG   . LYS A 1 277 ? -34.669 54.437 8.996   1.00 59.43  ? 277 LYS A CG   1 
ATOM   4223 C CD   . LYS A 1 277 ? -35.234 55.716 9.561   1.00 65.43  ? 277 LYS A CD   1 
ATOM   4224 C CE   . LYS A 1 277 ? -36.531 55.530 10.312  1.00 65.42  ? 277 LYS A CE   1 
ATOM   4225 N NZ   . LYS A 1 277 ? -36.374 54.615 11.464  1.00 70.99  ? 277 LYS A NZ   1 
ATOM   4226 H H    . LYS A 1 277 ? -32.756 55.021 7.085   1.00 67.54  ? 277 LYS A H    1 
ATOM   4227 H HA   . LYS A 1 277 ? -31.458 53.376 8.703   1.00 67.04  ? 277 LYS A HA   1 
ATOM   4228 H HB2  . LYS A 1 277 ? -33.144 53.809 10.216  1.00 67.90  ? 277 LYS A HB2  1 
ATOM   4229 H HB3  . LYS A 1 277 ? -32.801 55.151 9.453   1.00 67.90  ? 277 LYS A HB3  1 
ATOM   4230 H HG2  . LYS A 1 277 ? -34.767 54.445 8.021   1.00 71.37  ? 277 LYS A HG2  1 
ATOM   4231 H HG3  . LYS A 1 277 ? -35.176 53.673 9.344   1.00 71.37  ? 277 LYS A HG3  1 
ATOM   4232 H HD2  . LYS A 1 277 ? -34.575 56.111 10.168  1.00 78.56  ? 277 LYS A HD2  1 
ATOM   4233 H HD3  . LYS A 1 277 ? -35.383 56.348 8.827   1.00 78.56  ? 277 LYS A HD3  1 
ATOM   4234 H HE2  . LYS A 1 277 ? -36.847 56.394 10.634  1.00 78.55  ? 277 LYS A HE2  1 
ATOM   4235 H HE3  . LYS A 1 277 ? -37.206 55.169 9.710   1.00 78.55  ? 277 LYS A HE3  1 
ATOM   4236 H HZ1  . LYS A 1 277 ? -36.658 53.784 11.235  1.00 85.24  ? 277 LYS A HZ1  1 
ATOM   4237 H HZ2  . LYS A 1 277 ? -36.864 54.914 12.166  1.00 85.24  ? 277 LYS A HZ2  1 
ATOM   4238 H HZ3  . LYS A 1 277 ? -35.502 54.572 11.706  1.00 85.24  ? 277 LYS A HZ3  1 
ATOM   4239 N N    . HIS A 1 278 ? -33.925 51.929 7.206   1.00 57.47  ? 278 HIS A N    1 
ATOM   4240 C CA   . HIS A 1 278 ? -34.530 50.610 7.017   1.00 52.01  ? 278 HIS A CA   1 
ATOM   4241 C C    . HIS A 1 278 ? -33.555 49.664 6.313   1.00 51.89  ? 278 HIS A C    1 
ATOM   4242 O O    . HIS A 1 278 ? -33.346 48.524 6.752   1.00 49.43  ? 278 HIS A O    1 
ATOM   4243 C CB   . HIS A 1 278 ? -35.841 50.739 6.230   1.00 50.83  ? 278 HIS A CB   1 
ATOM   4244 C CG   . HIS A 1 278 ? -36.677 51.927 6.621   1.00 53.67  ? 278 HIS A CG   1 
ATOM   4245 N ND1  . HIS A 1 278 ? -37.278 52.047 7.857   1.00 55.44  ? 278 HIS A ND1  1 
ATOM   4246 C CD2  . HIS A 1 278 ? -37.005 53.050 5.938   1.00 48.09  ? 278 HIS A CD2  1 
ATOM   4247 C CE1  . HIS A 1 278 ? -37.929 53.192 7.919   1.00 49.90  ? 278 HIS A CE1  1 
ATOM   4248 N NE2  . HIS A 1 278 ? -37.789 53.815 6.763   1.00 53.32  ? 278 HIS A NE2  1 
ATOM   4249 H H    . HIS A 1 278 ? -34.226 52.546 6.687   1.00 69.02  ? 278 HIS A H    1 
ATOM   4250 H HA   . HIS A 1 278 ? -34.745 50.231 7.884   1.00 62.46  ? 278 HIS A HA   1 
ATOM   4251 H HB2  . HIS A 1 278 ? -35.630 50.824 5.287   1.00 61.05  ? 278 HIS A HB2  1 
ATOM   4252 H HB3  . HIS A 1 278 ? -36.373 49.942 6.380   1.00 61.05  ? 278 HIS A HB3  1 
ATOM   4253 H HD1  . HIS A 1 278 ? -37.235 51.465 8.489   1.00 66.58  ? 278 HIS A HD1  1 
ATOM   4254 H HD2  . HIS A 1 278 ? -36.746 53.263 5.070   1.00 57.76  ? 278 HIS A HD2  1 
ATOM   4255 H HE1  . HIS A 1 278 ? -38.406 53.508 8.653   1.00 59.93  ? 278 HIS A HE1  1 
ATOM   4256 N N    . GLN A 1 279 ? -32.938 50.123 5.219   1.00 47.52  ? 279 GLN A N    1 
ATOM   4257 C CA   . GLN A 1 279 ? -31.961 49.294 4.518   1.00 53.09  ? 279 GLN A CA   1 
ATOM   4258 C C    . GLN A 1 279 ? -30.865 48.851 5.465   1.00 52.99  ? 279 GLN A C    1 
ATOM   4259 O O    . GLN A 1 279 ? -30.449 47.688 5.453   1.00 54.28  ? 279 GLN A O    1 
ATOM   4260 C CB   . GLN A 1 279 ? -31.358 50.053 3.334   1.00 54.04  ? 279 GLN A CB   1 
ATOM   4261 C CG   . GLN A 1 279 ? -30.472 49.187 2.440   1.00 53.62  ? 279 GLN A CG   1 
ATOM   4262 C CD   . GLN A 1 279 ? -31.271 48.120 1.701   1.00 51.64  ? 279 GLN A CD   1 
ATOM   4263 O OE1  . GLN A 1 279 ? -32.459 48.291 1.436   1.00 49.86  ? 279 GLN A OE1  1 
ATOM   4264 N NE2  . GLN A 1 279 ? -30.624 47.025 1.359   1.00 45.76  ? 279 GLN A NE2  1 
ATOM   4265 H H    . GLN A 1 279 ? -33.066 50.899 4.869   1.00 57.07  ? 279 GLN A H    1 
ATOM   4266 H HA   . GLN A 1 279 ? -32.412 48.511 4.165   1.00 63.76  ? 279 GLN A HA   1 
ATOM   4267 H HB2  . GLN A 1 279 ? -32.078 50.404 2.788   1.00 64.90  ? 279 GLN A HB2  1 
ATOM   4268 H HB3  . GLN A 1 279 ? -30.814 50.781 3.674   1.00 64.90  ? 279 GLN A HB3  1 
ATOM   4269 H HG2  . GLN A 1 279 ? -30.037 49.750 1.781   1.00 64.40  ? 279 GLN A HG2  1 
ATOM   4270 H HG3  . GLN A 1 279 ? -29.806 48.742 2.987   1.00 64.40  ? 279 GLN A HG3  1 
ATOM   4271 H HE21 . GLN A 1 279 ? -31.035 46.395 0.941   1.00 54.96  ? 279 GLN A HE21 1 
ATOM   4272 H HE22 . GLN A 1 279 ? -29.791 46.939 1.555   1.00 54.96  ? 279 GLN A HE22 1 
ATOM   4273 N N    . ARG A 1 280 ? -30.407 49.761 6.320   1.00 52.58  ? 280 ARG A N    1 
ATOM   4274 C CA   . ARG A 1 280 ? -29.341 49.423 7.253   1.00 53.16  ? 280 ARG A CA   1 
ATOM   4275 C C    . ARG A 1 280 ? -29.799 48.353 8.236   1.00 53.17  ? 280 ARG A C    1 
ATOM   4276 O O    . ARG A 1 280 ? -29.075 47.401 8.509   1.00 49.75  ? 280 ARG A O    1 
ATOM   4277 C CB   . ARG A 1 280 ? -28.886 50.673 8.011   1.00 59.57  ? 280 ARG A CB   1 
ATOM   4278 C CG   . ARG A 1 280 ? -27.883 51.549 7.273   1.00 79.37  ? 280 ARG A CG   1 
ATOM   4279 C CD   . ARG A 1 280 ? -27.487 52.784 8.118   1.00 92.71  ? 280 ARG A CD   1 
ATOM   4280 N NE   . ARG A 1 280 ? -28.224 53.974 7.673   1.00 77.11  ? 280 ARG A NE   1 
ATOM   4281 C CZ   . ARG A 1 280 ? -29.038 54.705 8.432   1.00 68.10  ? 280 ARG A CZ   1 
ATOM   4282 N NH1  . ARG A 1 280 ? -29.230 54.419 9.727   1.00 66.09  ? 280 ARG A NH1  1 
ATOM   4283 N NH2  . ARG A 1 280 ? -29.666 55.738 7.883   1.00 59.29  ? 280 ARG A NH2  1 
ATOM   4284 H H    . ARG A 1 280 ? -30.693 50.570 6.380   1.00 63.15  ? 280 ARG A H    1 
ATOM   4285 H HA   . ARG A 1 280 ? -28.586 49.080 6.750   1.00 63.84  ? 280 ARG A HA   1 
ATOM   4286 H HB2  . ARG A 1 280 ? -29.666 51.219 8.197   1.00 71.54  ? 280 ARG A HB2  1 
ATOM   4287 H HB3  . ARG A 1 280 ? -28.471 50.394 8.842   1.00 71.54  ? 280 ARG A HB3  1 
ATOM   4288 H HG2  . ARG A 1 280 ? -27.081 51.035 7.088   1.00 95.29  ? 280 ARG A HG2  1 
ATOM   4289 H HG3  . ARG A 1 280 ? -28.277 51.860 6.443   1.00 95.29  ? 280 ARG A HG3  1 
ATOM   4290 H HD2  . ARG A 1 280 ? -27.700 52.620 9.051   1.00 111.30 ? 280 ARG A HD2  1 
ATOM   4291 H HD3  . ARG A 1 280 ? -26.538 52.954 8.020   1.00 111.30 ? 280 ARG A HD3  1 
ATOM   4292 H HE   . ARG A 1 280 ? -28.121 54.218 6.855   1.00 92.58  ? 280 ARG A HE   1 
ATOM   4293 H HH11 . ARG A 1 280 ? -28.823 53.751 10.084  1.00 79.36  ? 280 ARG A HH11 1 
ATOM   4294 H HH12 . ARG A 1 280 ? -29.760 54.903 10.200  1.00 79.36  ? 280 ARG A HH12 1 
ATOM   4295 H HH21 . ARG A 1 280 ? -29.543 55.924 7.052   1.00 71.20  ? 280 ARG A HH21 1 
ATOM   4296 H HH22 . ARG A 1 280 ? -30.196 56.222 8.357   1.00 71.20  ? 280 ARG A HH22 1 
ATOM   4297 N N    . ARG A 1 281 ? -30.987 48.508 8.813   1.00 55.73  ? 281 ARG A N    1 
ATOM   4298 C CA   . ARG A 1 281 ? -31.466 47.512 9.771   1.00 54.99  ? 281 ARG A CA   1 
ATOM   4299 C C    . ARG A 1 281 ? -31.676 46.146 9.100   1.00 49.50  ? 281 ARG A C    1 
ATOM   4300 O O    . ARG A 1 281 ? -31.461 45.098 9.725   1.00 43.35  ? 281 ARG A O    1 
ATOM   4301 C CB   . ARG A 1 281 ? -32.741 48.063 10.415  1.00 59.29  ? 281 ARG A CB   1 
ATOM   4302 C CG   . ARG A 1 281 ? -33.229 47.403 11.685  1.00 70.11  ? 281 ARG A CG   1 
ATOM   4303 C CD   . ARG A 1 281 ? -34.559 48.035 12.140  1.00 81.10  ? 281 ARG A CD   1 
ATOM   4304 N NE   . ARG A 1 281 ? -34.431 49.470 12.439  1.00 100.41 ? 281 ARG A NE   1 
ATOM   4305 C CZ   . ARG A 1 281 ? -35.405 50.372 12.283  1.00 97.68  ? 281 ARG A CZ   1 
ATOM   4306 N NH1  . ARG A 1 281 ? -36.600 50.009 11.824  1.00 120.45 ? 281 ARG A NH1  1 
ATOM   4307 N NH2  . ARG A 1 281 ? -35.187 51.652 12.588  1.00 84.44  ? 281 ARG A NH2  1 
ATOM   4308 H H    . ARG A 1 281 ? -31.525 49.164 8.673   1.00 66.93  ? 281 ARG A H    1 
ATOM   4309 H HA   . ARG A 1 281 ? -30.820 47.359 10.477  1.00 66.04  ? 281 ARG A HA   1 
ATOM   4310 H HB2  . ARG A 1 281 ? -32.586 48.996 10.627  1.00 71.20  ? 281 ARG A HB2  1 
ATOM   4311 H HB3  . ARG A 1 281 ? -33.458 47.984 9.766   1.00 71.20  ? 281 ARG A HB3  1 
ATOM   4312 H HG2  . ARG A 1 281 ? -33.375 46.457 11.526  1.00 84.19  ? 281 ARG A HG2  1 
ATOM   4313 H HG3  . ARG A 1 281 ? -32.573 47.524 12.388  1.00 84.19  ? 281 ARG A HG3  1 
ATOM   4314 H HD2  . ARG A 1 281 ? -35.216 47.933 11.433  1.00 97.38  ? 281 ARG A HD2  1 
ATOM   4315 H HD3  . ARG A 1 281 ? -34.864 47.586 12.944  1.00 97.38  ? 281 ARG A HD3  1 
ATOM   4316 H HE   . ARG A 1 281 ? -33.674 49.749 12.736  1.00 120.54 ? 281 ARG A HE   1 
ATOM   4317 H HH11 . ARG A 1 281 ? -36.752 49.187 11.624  1.00 144.59 ? 281 ARG A HH11 1 
ATOM   4318 H HH12 . ARG A 1 281 ? -37.220 50.597 11.727  1.00 144.59 ? 281 ARG A HH12 1 
ATOM   4319 H HH21 . ARG A 1 281 ? -34.418 51.897 12.886  1.00 101.38 ? 281 ARG A HH21 1 
ATOM   4320 H HH22 . ARG A 1 281 ? -35.814 52.231 12.487  1.00 101.38 ? 281 ARG A HH22 1 
ATOM   4321 N N    . LEU A 1 282 ? -32.048 46.145 7.818   1.00 50.88  ? 282 LEU A N    1 
ATOM   4322 C CA   . LEU A 1 282 ? -32.255 44.904 7.084   1.00 45.97  ? 282 LEU A CA   1 
ATOM   4323 C C    . LEU A 1 282 ? -30.949 44.151 6.874   1.00 50.16  ? 282 LEU A C    1 
ATOM   4324 O O    . LEU A 1 282 ? -30.950 42.910 6.871   1.00 43.14  ? 282 LEU A O    1 
ATOM   4325 C CB   . LEU A 1 282 ? -32.889 45.207 5.728   1.00 44.66  ? 282 LEU A CB   1 
ATOM   4326 C CG   . LEU A 1 282 ? -33.107 44.014 4.791   1.00 48.51  ? 282 LEU A CG   1 
ATOM   4327 C CD1  . LEU A 1 282 ? -34.168 43.040 5.293   1.00 50.53  ? 282 LEU A CD1  1 
ATOM   4328 C CD2  . LEU A 1 282 ? -33.498 44.538 3.379   1.00 45.21  ? 282 LEU A CD2  1 
ATOM   4329 H H    . LEU A 1 282 ? -32.187 46.853 7.351   1.00 61.10  ? 282 LEU A H    1 
ATOM   4330 H HA   . LEU A 1 282 ? -32.856 44.339 7.594   1.00 55.22  ? 282 LEU A HA   1 
ATOM   4331 H HB2  . LEU A 1 282 ? -33.759 45.606 5.887   1.00 53.64  ? 282 LEU A HB2  1 
ATOM   4332 H HB3  . LEU A 1 282 ? -32.316 45.834 5.262   1.00 53.64  ? 282 LEU A HB3  1 
ATOM   4333 H HG   . LEU A 1 282 ? -32.277 43.513 4.750   1.00 58.26  ? 282 LEU A HG   1 
ATOM   4334 H HD11 . LEU A 1 282 ? -34.238 42.300 4.670   1.00 60.69  ? 282 LEU A HD11 1 
ATOM   4335 H HD12 . LEU A 1 282 ? -33.908 42.713 6.168   1.00 60.69  ? 282 LEU A HD12 1 
ATOM   4336 H HD13 . LEU A 1 282 ? -35.019 43.503 5.352   1.00 60.69  ? 282 LEU A HD13 1 
ATOM   4337 H HD21 . LEU A 1 282 ? -33.752 43.786 2.822   1.00 54.31  ? 282 LEU A HD21 1 
ATOM   4338 H HD22 . LEU A 1 282 ? -32.736 44.996 2.990   1.00 54.31  ? 282 LEU A HD22 1 
ATOM   4339 H HD23 . LEU A 1 282 ? -34.244 45.152 3.466   1.00 54.31  ? 282 LEU A HD23 1 
ATOM   4340 N N    . VAL A 1 283 ? -29.844 44.882 6.648   1.00 45.06  ? 283 VAL A N    1 
ATOM   4341 C CA   . VAL A 1 283 ? -28.535 44.264 6.468   1.00 50.18  ? 283 VAL A CA   1 
ATOM   4342 C C    . VAL A 1 283 ? -28.080 43.582 7.747   1.00 50.23  ? 283 VAL A C    1 
ATOM   4343 O O    . VAL A 1 283 ? -27.591 42.442 7.724   1.00 50.60  ? 283 VAL A O    1 
ATOM   4344 C CB   . VAL A 1 283 ? -27.513 45.318 6.012   1.00 53.30  ? 283 VAL A CB   1 
ATOM   4345 C CG1  . VAL A 1 283 ? -26.127 44.794 6.124   1.00 55.08  ? 283 VAL A CG1  1 
ATOM   4346 C CG2  . VAL A 1 283 ? -27.754 45.615 4.517   1.00 50.11  ? 283 VAL A CG2  1 
ATOM   4347 H H    . VAL A 1 283 ? -29.832 45.741 6.595   1.00 54.13  ? 283 VAL A H    1 
ATOM   4348 H HA   . VAL A 1 283 ? -28.611 43.586 5.779   1.00 60.27  ? 283 VAL A HA   1 
ATOM   4349 H HB   . VAL A 1 283 ? -27.614 46.108 6.565   1.00 64.01  ? 283 VAL A HB   1 
ATOM   4350 H HG11 . VAL A 1 283 ? -25.528 45.379 5.634   1.00 66.14  ? 283 VAL A HG11 1 
ATOM   4351 H HG12 . VAL A 1 283 ? -25.873 44.769 7.060   1.00 66.14  ? 283 VAL A HG12 1 
ATOM   4352 H HG13 . VAL A 1 283 ? -26.096 43.900 5.749   1.00 66.14  ? 283 VAL A HG13 1 
ATOM   4353 H HG21 . VAL A 1 283 ? -27.113 46.280 4.220   1.00 60.18  ? 283 VAL A HG21 1 
ATOM   4354 H HG22 . VAL A 1 283 ? -27.639 44.797 4.009   1.00 60.18  ? 283 VAL A HG22 1 
ATOM   4355 H HG23 . VAL A 1 283 ? -28.656 45.952 4.403   1.00 60.18  ? 283 VAL A HG23 1 
ATOM   4356 N N    . LYS A 1 284 ? -28.190 44.282 8.886   1.00 49.26  ? 284 LYS A N    1 
ATOM   4357 C CA   . LYS A 1 284 ? -27.810 43.675 10.163  1.00 52.87  ? 284 LYS A CA   1 
ATOM   4358 C C    . LYS A 1 284 ? -28.614 42.409 10.406  1.00 48.06  ? 284 LYS A C    1 
ATOM   4359 O O    . LYS A 1 284 ? -28.082 41.409 10.898  1.00 55.62  ? 284 LYS A O    1 
ATOM   4360 C CB   . LYS A 1 284 ? -28.037 44.648 11.316  1.00 53.49  ? 284 LYS A CB   1 
ATOM   4361 C CG   . LYS A 1 284 ? -26.954 45.712 11.486  1.00 65.89  ? 284 LYS A CG   1 
ATOM   4362 C CD   . LYS A 1 284 ? -26.823 46.550 10.214  1.00 73.02  ? 284 LYS A CD   1 
ATOM   4363 C CE   . LYS A 1 284 ? -26.327 47.976 10.476  1.00 86.82  ? 284 LYS A CE   1 
ATOM   4364 N NZ   . LYS A 1 284 ? -25.985 48.627 9.154   1.00 78.55  ? 284 LYS A NZ   1 
ATOM   4365 H H    . LYS A 1 284 ? -28.475 45.091 8.943   1.00 59.16  ? 284 LYS A H    1 
ATOM   4366 H HA   . LYS A 1 284 ? -26.864 43.463 10.133  1.00 63.50  ? 284 LYS A HA   1 
ATOM   4367 H HB2  . LYS A 1 284 ? -28.877 45.109 11.168  1.00 64.24  ? 284 LYS A HB2  1 
ATOM   4368 H HB3  . LYS A 1 284 ? -28.079 44.141 12.142  1.00 64.24  ? 284 LYS A HB3  1 
ATOM   4369 H HG2  . LYS A 1 284 ? -27.189 46.300 12.221  1.00 79.12  ? 284 LYS A HG2  1 
ATOM   4370 H HG3  . LYS A 1 284 ? -26.102 45.283 11.663  1.00 79.12  ? 284 LYS A HG3  1 
ATOM   4371 H HD2  . LYS A 1 284 ? -26.189 46.121 9.618   1.00 87.68  ? 284 LYS A HD2  1 
ATOM   4372 H HD3  . LYS A 1 284 ? -27.691 46.611 9.786   1.00 87.68  ? 284 LYS A HD3  1 
ATOM   4373 H HE2  . LYS A 1 284 ? -27.023 48.493 10.912  1.00 104.23 ? 284 LYS A HE2  1 
ATOM   4374 H HE3  . LYS A 1 284 ? -25.533 47.953 11.032  1.00 104.23 ? 284 LYS A HE3  1 
ATOM   4375 H HZ1  . LYS A 1 284 ? -25.200 48.326 8.860   1.00 94.32  ? 284 LYS A HZ1  1 
ATOM   4376 H HZ2  . LYS A 1 284 ? -25.937 49.510 9.253   1.00 94.32  ? 284 LYS A HZ2  1 
ATOM   4377 H HZ3  . LYS A 1 284 ? -26.611 48.437 8.550   1.00 94.32  ? 284 LYS A HZ3  1 
ATOM   4378 N N    . LEU A 1 285 ? -29.924 42.467 10.128  1.00 46.75  ? 285 LEU A N    1 
ATOM   4379 C CA   . LEU A 1 285 ? -30.788 41.321 10.363  1.00 46.31  ? 285 LEU A CA   1 
ATOM   4380 C C    . LEU A 1 285 ? -30.268 40.091 9.640   1.00 39.48  ? 285 LEU A C    1 
ATOM   4381 O O    . LEU A 1 285 ? -30.071 39.041 10.257  1.00 45.80  ? 285 LEU A O    1 
ATOM   4382 C CB   . LEU A 1 285 ? -32.216 41.634 9.916   1.00 47.54  ? 285 LEU A CB   1 
ATOM   4383 C CG   . LEU A 1 285 ? -33.276 40.567 10.192  1.00 45.64  ? 285 LEU A CG   1 
ATOM   4384 C CD1  . LEU A 1 285 ? -33.319 40.279 11.697  1.00 48.47  ? 285 LEU A CD1  1 
ATOM   4385 C CD2  . LEU A 1 285 ? -34.689 40.928 9.725   1.00 47.69  ? 285 LEU A CD2  1 
ATOM   4386 H H    . LEU A 1 285 ? -30.327 43.155 9.806   1.00 56.15  ? 285 LEU A H    1 
ATOM   4387 H HA   . LEU A 1 285 ? -30.803 41.135 11.315  1.00 55.62  ? 285 LEU A HA   1 
ATOM   4388 H HB2  . LEU A 1 285 ? -32.502 42.441 10.372  1.00 57.10  ? 285 LEU A HB2  1 
ATOM   4389 H HB3  . LEU A 1 285 ? -32.204 41.780 8.957   1.00 57.10  ? 285 LEU A HB3  1 
ATOM   4390 H HG   . LEU A 1 285 ? -33.016 39.786 9.679   1.00 54.82  ? 285 LEU A HG   1 
ATOM   4391 H HD11 . LEU A 1 285 ? -32.535 39.764 11.943  1.00 58.22  ? 285 LEU A HD11 1 
ATOM   4392 H HD12 . LEU A 1 285 ? -34.123 39.775 11.899  1.00 58.22  ? 285 LEU A HD12 1 
ATOM   4393 H HD13 . LEU A 1 285 ? -33.327 41.121 12.179  1.00 58.22  ? 285 LEU A HD13 1 
ATOM   4394 H HD21 . LEU A 1 285 ? -34.666 41.125 8.775   1.00 57.28  ? 285 LEU A HD21 1 
ATOM   4395 H HD22 . LEU A 1 285 ? -35.278 40.176 9.893   1.00 57.28  ? 285 LEU A HD22 1 
ATOM   4396 H HD23 . LEU A 1 285 ? -34.995 41.705 10.217  1.00 57.28  ? 285 LEU A HD23 1 
ATOM   4397 N N    . LEU A 1 286 ? -30.002 40.210 8.345   1.00 37.36  ? 286 LEU A N    1 
ATOM   4398 C CA   . LEU A 1 286 ? -29.834 39.029 7.505   1.00 46.23  ? 286 LEU A CA   1 
ATOM   4399 C C    . LEU A 1 286 ? -28.385 38.552 7.365   1.00 48.33  ? 286 LEU A C    1 
ATOM   4400 O O    . LEU A 1 286 ? -28.154 37.421 6.904   1.00 45.85  ? 286 LEU A O    1 
ATOM   4401 C CB   . LEU A 1 286 ? -30.404 39.285 6.101   1.00 42.29  ? 286 LEU A CB   1 
ATOM   4402 C CG   . LEU A 1 286 ? -31.888 39.653 6.009   1.00 43.17  ? 286 LEU A CG   1 
ATOM   4403 C CD1  . LEU A 1 286 ? -32.404 39.953 4.589   1.00 41.28  ? 286 LEU A CD1  1 
ATOM   4404 C CD2  . LEU A 1 286 ? -32.731 38.530 6.614   1.00 48.34  ? 286 LEU A CD2  1 
ATOM   4405 H H    . LEU A 1 286 ? -29.913 40.959 7.930   1.00 44.89  ? 286 LEU A H    1 
ATOM   4406 H HA   . LEU A 1 286 ? -30.336 38.309 7.918   1.00 55.53  ? 286 LEU A HA   1 
ATOM   4407 H HB2  . LEU A 1 286 ? -29.906 40.018 5.705   1.00 50.80  ? 286 LEU A HB2  1 
ATOM   4408 H HB3  . LEU A 1 286 ? -30.280 38.479 5.576   1.00 50.80  ? 286 LEU A HB3  1 
ATOM   4409 H HG   . LEU A 1 286 ? -31.985 40.482 6.503   1.00 51.86  ? 286 LEU A HG   1 
ATOM   4410 H HD11 . LEU A 1 286 ? -31.773 39.601 3.942   1.00 49.59  ? 286 LEU A HD11 1 
ATOM   4411 H HD12 . LEU A 1 286 ? -33.269 39.530 4.471   1.00 49.59  ? 286 LEU A HD12 1 
ATOM   4412 H HD13 . LEU A 1 286 ? -32.489 40.913 4.480   1.00 49.59  ? 286 LEU A HD13 1 
ATOM   4413 H HD21 . LEU A 1 286 ? -33.666 38.699 6.420   1.00 58.06  ? 286 LEU A HD21 1 
ATOM   4414 H HD22 . LEU A 1 286 ? -32.590 38.511 7.573   1.00 58.06  ? 286 LEU A HD22 1 
ATOM   4415 H HD23 . LEU A 1 286 ? -32.459 37.685 6.223   1.00 58.06  ? 286 LEU A HD23 1 
ATOM   4416 N N    . LEU A 1 287 ? -27.408 39.373 7.711   1.00 50.04  ? 287 LEU A N    1 
ATOM   4417 C CA   . LEU A 1 287 ? -26.019 38.969 7.535   1.00 52.30  ? 287 LEU A CA   1 
ATOM   4418 C C    . LEU A 1 287 ? -25.276 38.800 8.854   1.00 57.15  ? 287 LEU A C    1 
ATOM   4419 O O    . LEU A 1 287 ? -24.416 37.918 8.979   1.00 67.02  ? 287 LEU A O    1 
ATOM   4420 C CB   . LEU A 1 287 ? -25.307 39.977 6.647   1.00 55.70  ? 287 LEU A CB   1 
ATOM   4421 C CG   . LEU A 1 287 ? -26.053 40.338 5.367   1.00 57.88  ? 287 LEU A CG   1 
ATOM   4422 C CD1  . LEU A 1 287 ? -25.194 41.295 4.553   1.00 56.46  ? 287 LEU A CD1  1 
ATOM   4423 C CD2  . LEU A 1 287 ? -26.417 39.124 4.540   1.00 59.90  ? 287 LEU A CD2  1 
ATOM   4424 O OXT  . LEU A 1 287 ? -25.537 39.518 9.818   1.00 63.03  ? 287 LEU A OXT  1 
ATOM   4425 H H    . LEU A 1 287 ? -27.519 40.157 8.045   1.00 60.10  ? 287 LEU A H    1 
ATOM   4426 H HA   . LEU A 1 287 ? -26.003 38.099 7.106   1.00 62.81  ? 287 LEU A HA   1 
ATOM   4427 H HB2  . LEU A 1 287 ? -25.179 40.796 7.152   1.00 66.89  ? 287 LEU A HB2  1 
ATOM   4428 H HB3  . LEU A 1 287 ? -24.447 39.608 6.391   1.00 66.89  ? 287 LEU A HB3  1 
ATOM   4429 H HG   . LEU A 1 287 ? -26.892 40.761 5.606   1.00 69.51  ? 287 LEU A HG   1 
ATOM   4430 H HD11 . LEU A 1 287 ? -24.386 40.835 4.274   1.00 67.80  ? 287 LEU A HD11 1 
ATOM   4431 H HD12 . LEU A 1 287 ? -24.965 42.060 5.103   1.00 67.80  ? 287 LEU A HD12 1 
ATOM   4432 H HD13 . LEU A 1 287 ? -25.695 41.585 3.774   1.00 67.80  ? 287 LEU A HD13 1 
ATOM   4433 H HD21 . LEU A 1 287 ? -27.026 38.567 5.049   1.00 71.93  ? 287 LEU A HD21 1 
ATOM   4434 H HD22 . LEU A 1 287 ? -25.609 38.629 4.333   1.00 71.93  ? 287 LEU A HD22 1 
ATOM   4435 H HD23 . LEU A 1 287 ? -26.844 39.417 3.720   1.00 71.93  ? 287 LEU A HD23 1 
HETATM 4436 O O    . HOH B 2 .   ? -29.167 33.026 4.658   1.00 41.80  ? 301 HOH A O    1 
HETATM 4437 O O    . HOH B 2 .   ? -49.174 24.183 -4.708  1.00 33.24  ? 302 HOH A O    1 
HETATM 4438 O O    . HOH B 2 .   ? -53.613 56.171 -8.202  1.00 48.95  ? 303 HOH A O    1 
HETATM 4439 O O    . HOH B 2 .   ? -36.944 7.616  -17.346 1.00 48.83  ? 304 HOH A O    1 
HETATM 4440 O O    . HOH B 2 .   ? -52.492 24.895 -10.738 1.00 47.53  ? 305 HOH A O    1 
HETATM 4441 O O    . HOH B 2 .   ? -38.641 21.136 -10.195 1.00 48.54  ? 306 HOH A O    1 
HETATM 4442 O O    . HOH B 2 .   ? -40.620 34.012 13.305  1.00 39.01  ? 307 HOH A O    1 
HETATM 4443 O O    . HOH B 2 .   ? -33.864 29.081 19.006  1.00 47.29  ? 308 HOH A O    1 
HETATM 4444 O O    . HOH B 2 .   ? -40.565 24.340 -8.559  1.00 38.58  ? 309 HOH A O    1 
HETATM 4445 O O    . HOH B 2 .   ? -35.760 15.583 13.800  1.00 44.39  ? 310 HOH A O    1 
HETATM 4446 O O    . HOH B 2 .   ? -35.326 29.362 16.656  1.00 42.90  ? 311 HOH A O    1 
HETATM 4447 O O    . HOH B 2 .   ? -58.050 50.739 -12.259 1.00 42.30  ? 312 HOH A O    1 
HETATM 4448 O O    . HOH B 2 .   ? -42.992 44.388 -11.186 1.00 43.99  ? 313 HOH A O    1 
HETATM 4449 O O    . HOH B 2 .   ? -42.564 11.840 12.245  1.00 46.23  ? 314 HOH A O    1 
HETATM 4450 O O    . HOH B 2 .   ? -51.794 24.688 -3.333  1.00 42.79  ? 315 HOH A O    1 
HETATM 4451 O O    . HOH B 2 .   ? -54.876 45.876 -13.171 1.00 53.35  ? 316 HOH A O    1 
HETATM 4452 O O    . HOH B 2 .   ? -43.947 39.597 11.506  1.00 43.66  ? 317 HOH A O    1 
HETATM 4453 O O    . HOH B 2 .   ? -53.999 17.381 -2.875  1.00 46.46  ? 318 HOH A O    1 
HETATM 4454 O O    . HOH B 2 .   ? -57.013 13.226 3.166   1.00 47.18  ? 319 HOH A O    1 
HETATM 4455 O O    . HOH B 2 .   ? -30.560 24.628 -3.267  1.00 38.91  ? 320 HOH A O    1 
HETATM 4456 O O    . HOH B 2 .   ? -30.730 25.932 12.310  1.00 46.82  ? 321 HOH A O    1 
HETATM 4457 O O    . HOH B 2 .   ? -31.903 27.071 -2.822  1.00 35.63  ? 322 HOH A O    1 
HETATM 4458 O O    . HOH B 2 .   ? -48.724 45.676 2.895   1.00 43.11  ? 323 HOH A O    1 
HETATM 4459 O O    . HOH B 2 .   ? -30.304 33.665 8.304   1.00 35.98  ? 324 HOH A O    1 
HETATM 4460 O O    . HOH B 2 .   ? -60.617 29.559 1.618   1.00 40.49  ? 325 HOH A O    1 
HETATM 4461 O O    . HOH B 2 .   ? -34.010 26.034 4.788   1.00 37.23  ? 326 HOH A O    1 
HETATM 4462 O O    . HOH B 2 .   ? -48.690 30.624 7.816   1.00 32.69  ? 327 HOH A O    1 
HETATM 4463 O O    . HOH B 2 .   ? -49.523 25.983 3.394   1.00 43.46  ? 328 HOH A O    1 
HETATM 4464 O O    . HOH B 2 .   ? -48.568 28.372 5.688   1.00 39.78  ? 329 HOH A O    1 
HETATM 4465 O O    . HOH B 2 .   ? -43.834 36.570 -14.048 1.00 46.79  ? 330 HOH A O    1 
HETATM 4466 O O    . HOH B 2 .   ? -39.070 30.054 -3.119  1.00 36.28  ? 331 HOH A O    1 
HETATM 4467 O O    . HOH B 2 .   ? -49.222 48.754 -14.731 1.00 49.84  ? 332 HOH A O    1 
HETATM 4468 O O    . HOH B 2 .   ? -48.702 24.456 -1.909  1.00 36.15  ? 333 HOH A O    1 
HETATM 4469 O O    . HOH B 2 .   ? -49.088 44.571 5.011   1.00 35.81  ? 334 HOH A O    1 
HETATM 4470 O O    . HOH B 2 .   ? -28.066 37.656 11.415  1.00 54.32  ? 335 HOH A O    1 
HETATM 4471 O O    . HOH B 2 .   ? -44.743 36.839 5.248   1.00 29.47  ? 336 HOH A O    1 
HETATM 4472 O O    . HOH B 2 .   ? -33.692 36.944 -9.215  1.00 41.33  ? 337 HOH A O    1 
HETATM 4473 O O    . HOH B 2 .   ? -50.138 44.660 -0.520  1.00 44.85  ? 338 HOH A O    1 
HETATM 4474 O O    . HOH B 2 .   ? -40.809 22.972 -10.460 1.00 45.06  ? 339 HOH A O    1 
HETATM 4475 O O    . HOH B 2 .   ? -44.087 39.026 3.780   1.00 33.58  ? 340 HOH A O    1 
HETATM 4476 O O    . HOH B 2 .   ? -42.110 20.108 17.309  1.00 47.76  ? 341 HOH A O    1 
HETATM 4477 O O    . HOH B 2 .   ? -56.523 36.128 4.427   1.00 42.26  ? 342 HOH A O    1 
HETATM 4478 O O    . HOH B 2 .   ? -41.989 52.663 6.356   1.00 50.62  ? 343 HOH A O    1 
HETATM 4479 O O    . HOH B 2 .   ? -48.985 48.942 0.000   0.50 45.17  ? 344 HOH A O    1 
HETATM 4480 O O    . HOH B 2 .   ? -54.682 18.450 -11.435 1.00 55.64  ? 345 HOH A O    1 
HETATM 4481 O O    . HOH B 2 .   ? -33.675 44.170 13.305  1.00 50.98  ? 346 HOH A O    1 
HETATM 4482 O O    . HOH B 2 .   ? -34.966 29.182 -1.687  1.00 33.18  ? 347 HOH A O    1 
HETATM 4483 O O    . HOH B 2 .   ? -54.226 14.500 13.298  1.00 56.32  ? 348 HOH A O    1 
HETATM 4484 O O    . HOH B 2 .   ? -40.466 43.511 -8.491  1.00 48.62  ? 349 HOH A O    1 
HETATM 4485 O O    . HOH B 2 .   ? -36.842 19.695 -15.677 1.00 47.14  ? 350 HOH A O    1 
HETATM 4486 O O    . HOH B 2 .   ? -41.833 41.765 -10.024 1.00 40.16  ? 351 HOH A O    1 
HETATM 4487 O O    . HOH B 2 .   ? -36.322 29.383 -3.662  1.00 30.93  ? 352 HOH A O    1 
HETATM 4488 O O    . HOH B 2 .   ? -30.291 35.595 6.546   1.00 43.27  ? 353 HOH A O    1 
HETATM 4489 O O    . HOH B 2 .   ? -51.387 28.839 2.662   1.00 40.48  ? 354 HOH A O    1 
HETATM 4490 O O    . HOH B 2 .   ? -43.674 10.881 10.473  1.00 47.03  ? 355 HOH A O    1 
HETATM 4491 O O    . HOH B 2 .   ? -51.608 32.607 9.974   1.00 48.64  ? 356 HOH A O    1 
HETATM 4492 O O    . HOH B 2 .   ? -33.314 57.424 6.227   1.00 58.88  ? 357 HOH A O    1 
HETATM 4493 O O    . HOH B 2 .   ? -46.083 9.334  -17.502 1.00 56.08  ? 358 HOH A O    1 
HETATM 4494 O O    . HOH B 2 .   ? -48.737 29.404 15.200  1.00 47.06  ? 359 HOH A O    1 
HETATM 4495 O O    . HOH B 2 .   ? -42.617 30.343 -3.154  1.00 33.19  ? 360 HOH A O    1 
HETATM 4496 O O    . HOH B 2 .   ? -52.582 44.291 -6.262  1.00 45.72  ? 361 HOH A O    1 
HETATM 4497 O O    . HOH B 2 .   ? -32.964 25.060 11.377  1.00 46.84  ? 362 HOH A O    1 
HETATM 4498 O O    . HOH B 2 .   ? -29.059 24.706 -0.787  1.00 46.78  ? 363 HOH A O    1 
HETATM 4499 O O    . HOH B 2 .   ? -27.188 50.528 2.629   1.00 56.16  ? 364 HOH A O    1 
HETATM 4500 O O    . HOH B 2 .   ? -53.629 12.909 -14.488 1.00 57.63  ? 365 HOH A O    1 
HETATM 4501 O O    . HOH B 2 .   ? -53.571 27.499 2.118   1.00 38.27  ? 366 HOH A O    1 
HETATM 4502 O O    . HOH B 2 .   ? -48.401 32.751 -6.470  1.00 49.46  ? 367 HOH A O    1 
HETATM 4503 O O    . HOH B 2 .   ? -37.266 47.003 -14.443 1.00 49.94  ? 368 HOH A O    1 
HETATM 4504 O O    . HOH B 2 .   ? -43.388 45.209 -17.847 1.00 49.81  ? 369 HOH A O    1 
HETATM 4505 O O    . HOH B 2 .   ? -32.306 58.147 8.333   1.00 61.57  ? 370 HOH A O    1 
HETATM 4506 O O    . HOH B 2 .   ? -42.059 24.806 -11.516 1.00 44.27  ? 371 HOH A O    1 
HETATM 4507 O O    . HOH B 2 .   ? -28.994 23.945 8.137   1.00 55.63  ? 372 HOH A O    1 
# 
