data_8Y0H
# 
_entry.id   8Y0H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Y0H         pdb_00008y0h 10.2210/pdb8y0h/pdb 
WWPDB D_1300044582 ?            ?                   
EMDB  EMD-38803    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 FSC               1 0 2025-02-26 ? 
4 'Half map'        1 0 2025-02-26 1 
5 'Half map'        1 0 2025-02-26 2 
6 Image             1 0 2025-02-26 ? 
7 'Primary map'     1 0 2025-02-26 ? 
8 'Structure model' 1 1 2025-04-09 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'     
2 8 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' citation        
2 8 'Structure model' citation_author 
3 8 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8 'Structure model' '_citation.country'                 
2  8 'Structure model' '_citation.journal_abbrev'          
3  8 'Structure model' '_citation.journal_id_CSD'          
4  8 'Structure model' '_citation.journal_id_ISSN'         
5  8 'Structure model' '_citation.journal_volume'          
6  8 'Structure model' '_citation.page_first'              
7  8 'Structure model' '_citation.page_last'               
8  8 'Structure model' '_citation.pdbx_database_id_DOI'    
9  8 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 8 'Structure model' '_citation.title'                   
11 8 'Structure model' '_citation.year'                    
12 8 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Y0H 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)' 
_pdbx_database_related.db_id          EMD-38803 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 arshukla@iitk.ac.in       Arun  Shukla K 'principal investigator/group leader' 0000-0003-2910-8288 
3 nureki@bs.s.u-tokyo.ac.jp Osamu Nureki ? 'principal investigator/group leader' 0000-0003-1813-7008 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sano, F.K.'   1 0000-0002-8965-788X 
'Saha, S.'     2 0000-0002-0036-4969 
'Sharma, S.'   3 0009-0005-9109-9054 
'Ganguly, M.'  4 0009-0007-6165-3063 
'Shihoya, W.'  5 0000-0003-4813-5740 
'Nureki, O.'   6 0000-0003-1813-7008 
'Shukla, A.K.' 7 0000-0003-2910-8288 
'Banerjee, R.' 8 0000-0002-7751-2317 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                3047 
_citation.page_last                 3047 
_citation.title                     
'Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-58264-w 
_citation.pdbx_database_id_PubMed   40155369 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Saha, S.'        1  ?                   
primary 'Sano, F.K.'      2  0000-0002-8965-788X 
primary 'Sharma, S.'      3  0009-0005-9109-9054 
primary 'Ganguly, M.'     4  ?                   
primary 'Dalal, A.'       5  ?                   
primary 'Mishra, S.'      6  ?                   
primary 'Tiwari, D.'      7  ?                   
primary 'Akasaka, H.'     8  0000-0003-2118-0912 
primary 'Kobayashi, T.A.' 9  0009-0007-4740-006X 
primary 'Roy, N.'         10 ?                   
primary 'Zaidi, N.'       11 ?                   
primary 'Itoh, Y.'        12 0000-0001-7802-5572 
primary 'Leurs, R.'       13 0000-0003-1354-2848 
primary 'Banerjee, R.'    14 0000-0002-7751-2317 
primary 'Shihoya, W.'     15 0000-0003-4813-5740 
primary 'Nureki, O.'      16 0000-0003-1813-7008 
primary 'Shukla, A.K.'    17 0000-0003-2910-8288 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'C-X-C chemokine receptor type 3' 46597.906 1 ? ? ? ? 
2 non-polymer syn 
'[(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium' 472.425   1 
? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        CXC-R3,CXCR-3,CKR-L2 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSVLEVSDHQVLNDAEVAALLENFS
SSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVL
TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFAL
PDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAF
ALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGL
QRQPSSSRRDSSWSETSEASYSGL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSVLEVSDHQVLNDAEVAALLENFS
SSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVL
TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFAL
PDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAF
ALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGL
QRQPSSSRRDSSWSETSEASYSGL
;
_entity_poly.pdbx_strand_id                 R 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        
'[(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium' 
_pdbx_entity_nonpoly.comp_id     A1LW2 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   LYS n 
1 4   THR n 
1 5   ILE n 
1 6   ILE n 
1 7   ALA n 
1 8   LEU n 
1 9   SER n 
1 10  TYR n 
1 11  ILE n 
1 12  PHE n 
1 13  CYS n 
1 14  LEU n 
1 15  VAL n 
1 16  PHE n 
1 17  ALA n 
1 18  ASP n 
1 19  TYR n 
1 20  LYS n 
1 21  ASP n 
1 22  ASP n 
1 23  ASP n 
1 24  ASP n 
1 25  ALA n 
1 26  ALA n 
1 27  ASN n 
1 28  PHE n 
1 29  THR n 
1 30  PRO n 
1 31  VAL n 
1 32  ASN n 
1 33  GLY n 
1 34  SER n 
1 35  SER n 
1 36  GLY n 
1 37  ASN n 
1 38  GLN n 
1 39  SER n 
1 40  VAL n 
1 41  ARG n 
1 42  LEU n 
1 43  VAL n 
1 44  THR n 
1 45  SER n 
1 46  SER n 
1 47  SER n 
1 48  LEU n 
1 49  GLU n 
1 50  VAL n 
1 51  LEU n 
1 52  PHE n 
1 53  GLN n 
1 54  GLY n 
1 55  PRO n 
1 56  GLY n 
1 57  SER n 
1 58  VAL n 
1 59  LEU n 
1 60  GLU n 
1 61  VAL n 
1 62  SER n 
1 63  ASP n 
1 64  HIS n 
1 65  GLN n 
1 66  VAL n 
1 67  LEU n 
1 68  ASN n 
1 69  ASP n 
1 70  ALA n 
1 71  GLU n 
1 72  VAL n 
1 73  ALA n 
1 74  ALA n 
1 75  LEU n 
1 76  LEU n 
1 77  GLU n 
1 78  ASN n 
1 79  PHE n 
1 80  SER n 
1 81  SER n 
1 82  SER n 
1 83  TYR n 
1 84  ASP n 
1 85  TYR n 
1 86  GLY n 
1 87  GLU n 
1 88  ASN n 
1 89  GLU n 
1 90  SER n 
1 91  ASP n 
1 92  SER n 
1 93  CYS n 
1 94  CYS n 
1 95  THR n 
1 96  SER n 
1 97  PRO n 
1 98  PRO n 
1 99  CYS n 
1 100 PRO n 
1 101 GLN n 
1 102 ASP n 
1 103 PHE n 
1 104 SER n 
1 105 LEU n 
1 106 ASN n 
1 107 PHE n 
1 108 ASP n 
1 109 ARG n 
1 110 ALA n 
1 111 PHE n 
1 112 LEU n 
1 113 PRO n 
1 114 ALA n 
1 115 LEU n 
1 116 TYR n 
1 117 SER n 
1 118 LEU n 
1 119 LEU n 
1 120 PHE n 
1 121 LEU n 
1 122 LEU n 
1 123 GLY n 
1 124 LEU n 
1 125 LEU n 
1 126 GLY n 
1 127 ASN n 
1 128 GLY n 
1 129 ALA n 
1 130 VAL n 
1 131 ALA n 
1 132 ALA n 
1 133 VAL n 
1 134 LEU n 
1 135 LEU n 
1 136 SER n 
1 137 ARG n 
1 138 ARG n 
1 139 THR n 
1 140 ALA n 
1 141 LEU n 
1 142 SER n 
1 143 SER n 
1 144 THR n 
1 145 ASP n 
1 146 THR n 
1 147 PHE n 
1 148 LEU n 
1 149 LEU n 
1 150 HIS n 
1 151 LEU n 
1 152 ALA n 
1 153 VAL n 
1 154 ALA n 
1 155 ASP n 
1 156 THR n 
1 157 LEU n 
1 158 LEU n 
1 159 VAL n 
1 160 LEU n 
1 161 THR n 
1 162 LEU n 
1 163 PRO n 
1 164 LEU n 
1 165 TRP n 
1 166 ALA n 
1 167 VAL n 
1 168 ASP n 
1 169 ALA n 
1 170 ALA n 
1 171 VAL n 
1 172 GLN n 
1 173 TRP n 
1 174 VAL n 
1 175 PHE n 
1 176 GLY n 
1 177 SER n 
1 178 GLY n 
1 179 LEU n 
1 180 CYS n 
1 181 LYS n 
1 182 VAL n 
1 183 ALA n 
1 184 GLY n 
1 185 ALA n 
1 186 LEU n 
1 187 PHE n 
1 188 ASN n 
1 189 ILE n 
1 190 ASN n 
1 191 PHE n 
1 192 TYR n 
1 193 ALA n 
1 194 GLY n 
1 195 ALA n 
1 196 LEU n 
1 197 LEU n 
1 198 LEU n 
1 199 ALA n 
1 200 CYS n 
1 201 ILE n 
1 202 SER n 
1 203 PHE n 
1 204 ASP n 
1 205 ARG n 
1 206 TYR n 
1 207 LEU n 
1 208 ASN n 
1 209 ILE n 
1 210 VAL n 
1 211 HIS n 
1 212 ALA n 
1 213 THR n 
1 214 GLN n 
1 215 LEU n 
1 216 TYR n 
1 217 ARG n 
1 218 ARG n 
1 219 GLY n 
1 220 PRO n 
1 221 PRO n 
1 222 ALA n 
1 223 ARG n 
1 224 VAL n 
1 225 THR n 
1 226 LEU n 
1 227 THR n 
1 228 CYS n 
1 229 LEU n 
1 230 ALA n 
1 231 VAL n 
1 232 TRP n 
1 233 GLY n 
1 234 LEU n 
1 235 CYS n 
1 236 LEU n 
1 237 LEU n 
1 238 PHE n 
1 239 ALA n 
1 240 LEU n 
1 241 PRO n 
1 242 ASP n 
1 243 PHE n 
1 244 ILE n 
1 245 PHE n 
1 246 LEU n 
1 247 SER n 
1 248 ALA n 
1 249 HIS n 
1 250 HIS n 
1 251 ASP n 
1 252 GLU n 
1 253 ARG n 
1 254 LEU n 
1 255 ASN n 
1 256 ALA n 
1 257 THR n 
1 258 HIS n 
1 259 CYS n 
1 260 GLN n 
1 261 TYR n 
1 262 ASN n 
1 263 PHE n 
1 264 PRO n 
1 265 GLN n 
1 266 VAL n 
1 267 GLY n 
1 268 ARG n 
1 269 THR n 
1 270 ALA n 
1 271 LEU n 
1 272 ARG n 
1 273 VAL n 
1 274 LEU n 
1 275 GLN n 
1 276 LEU n 
1 277 VAL n 
1 278 ALA n 
1 279 GLY n 
1 280 PHE n 
1 281 LEU n 
1 282 LEU n 
1 283 PRO n 
1 284 LEU n 
1 285 LEU n 
1 286 VAL n 
1 287 MET n 
1 288 ALA n 
1 289 TYR n 
1 290 CYS n 
1 291 TYR n 
1 292 ALA n 
1 293 HIS n 
1 294 ILE n 
1 295 LEU n 
1 296 ALA n 
1 297 VAL n 
1 298 LEU n 
1 299 LEU n 
1 300 VAL n 
1 301 SER n 
1 302 ARG n 
1 303 GLY n 
1 304 GLN n 
1 305 ARG n 
1 306 ARG n 
1 307 LEU n 
1 308 ARG n 
1 309 ALA n 
1 310 MET n 
1 311 ARG n 
1 312 LEU n 
1 313 VAL n 
1 314 VAL n 
1 315 VAL n 
1 316 VAL n 
1 317 VAL n 
1 318 VAL n 
1 319 ALA n 
1 320 PHE n 
1 321 ALA n 
1 322 LEU n 
1 323 CYS n 
1 324 TRP n 
1 325 THR n 
1 326 PRO n 
1 327 TYR n 
1 328 HIS n 
1 329 LEU n 
1 330 VAL n 
1 331 VAL n 
1 332 LEU n 
1 333 VAL n 
1 334 ASP n 
1 335 ILE n 
1 336 LEU n 
1 337 MET n 
1 338 ASP n 
1 339 LEU n 
1 340 GLY n 
1 341 ALA n 
1 342 LEU n 
1 343 ALA n 
1 344 ARG n 
1 345 ASN n 
1 346 CYS n 
1 347 GLY n 
1 348 ARG n 
1 349 GLU n 
1 350 SER n 
1 351 ARG n 
1 352 VAL n 
1 353 ASP n 
1 354 VAL n 
1 355 ALA n 
1 356 LYS n 
1 357 SER n 
1 358 VAL n 
1 359 THR n 
1 360 SER n 
1 361 GLY n 
1 362 LEU n 
1 363 GLY n 
1 364 TYR n 
1 365 MET n 
1 366 HIS n 
1 367 CYS n 
1 368 CYS n 
1 369 LEU n 
1 370 ASN n 
1 371 PRO n 
1 372 LEU n 
1 373 LEU n 
1 374 TYR n 
1 375 ALA n 
1 376 PHE n 
1 377 VAL n 
1 378 GLY n 
1 379 VAL n 
1 380 LYS n 
1 381 PHE n 
1 382 ARG n 
1 383 GLU n 
1 384 ARG n 
1 385 MET n 
1 386 TRP n 
1 387 MET n 
1 388 LEU n 
1 389 LEU n 
1 390 LEU n 
1 391 ARG n 
1 392 LEU n 
1 393 GLY n 
1 394 CYS n 
1 395 PRO n 
1 396 ASN n 
1 397 GLN n 
1 398 ARG n 
1 399 GLY n 
1 400 LEU n 
1 401 GLN n 
1 402 ARG n 
1 403 GLN n 
1 404 PRO n 
1 405 SER n 
1 406 SER n 
1 407 SER n 
1 408 ARG n 
1 409 ARG n 
1 410 ASP n 
1 411 SER n 
1 412 SER n 
1 413 TRP n 
1 414 SER n 
1 415 GLU n 
1 416 THR n 
1 417 SER n 
1 418 GLU n 
1 419 ALA n 
1 420 SER n 
1 421 TYR n 
1 422 SER n 
1 423 GLY n 
1 424 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   424 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CXCR3 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LW2 non-polymer         . 
'[(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium' ? 
'C25 H31 I N 1'  472.425 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -55 ?   ?   ?   R . n 
A 1 2   GLY 2   -54 ?   ?   ?   R . n 
A 1 3   LYS 3   -53 ?   ?   ?   R . n 
A 1 4   THR 4   -52 ?   ?   ?   R . n 
A 1 5   ILE 5   -51 ?   ?   ?   R . n 
A 1 6   ILE 6   -50 ?   ?   ?   R . n 
A 1 7   ALA 7   -49 ?   ?   ?   R . n 
A 1 8   LEU 8   -48 ?   ?   ?   R . n 
A 1 9   SER 9   -47 ?   ?   ?   R . n 
A 1 10  TYR 10  -46 ?   ?   ?   R . n 
A 1 11  ILE 11  -45 ?   ?   ?   R . n 
A 1 12  PHE 12  -44 ?   ?   ?   R . n 
A 1 13  CYS 13  -43 ?   ?   ?   R . n 
A 1 14  LEU 14  -42 ?   ?   ?   R . n 
A 1 15  VAL 15  -41 ?   ?   ?   R . n 
A 1 16  PHE 16  -40 ?   ?   ?   R . n 
A 1 17  ALA 17  -39 ?   ?   ?   R . n 
A 1 18  ASP 18  -38 ?   ?   ?   R . n 
A 1 19  TYR 19  -37 ?   ?   ?   R . n 
A 1 20  LYS 20  -36 ?   ?   ?   R . n 
A 1 21  ASP 21  -35 ?   ?   ?   R . n 
A 1 22  ASP 22  -34 ?   ?   ?   R . n 
A 1 23  ASP 23  -33 ?   ?   ?   R . n 
A 1 24  ASP 24  -32 ?   ?   ?   R . n 
A 1 25  ALA 25  -31 ?   ?   ?   R . n 
A 1 26  ALA 26  -30 ?   ?   ?   R . n 
A 1 27  ASN 27  -29 ?   ?   ?   R . n 
A 1 28  PHE 28  -28 ?   ?   ?   R . n 
A 1 29  THR 29  -27 ?   ?   ?   R . n 
A 1 30  PRO 30  -26 ?   ?   ?   R . n 
A 1 31  VAL 31  -25 ?   ?   ?   R . n 
A 1 32  ASN 32  -24 ?   ?   ?   R . n 
A 1 33  GLY 33  -23 ?   ?   ?   R . n 
A 1 34  SER 34  -22 ?   ?   ?   R . n 
A 1 35  SER 35  -21 ?   ?   ?   R . n 
A 1 36  GLY 36  -20 ?   ?   ?   R . n 
A 1 37  ASN 37  -19 ?   ?   ?   R . n 
A 1 38  GLN 38  -18 ?   ?   ?   R . n 
A 1 39  SER 39  -17 ?   ?   ?   R . n 
A 1 40  VAL 40  -16 ?   ?   ?   R . n 
A 1 41  ARG 41  -15 ?   ?   ?   R . n 
A 1 42  LEU 42  -14 ?   ?   ?   R . n 
A 1 43  VAL 43  -13 ?   ?   ?   R . n 
A 1 44  THR 44  -12 ?   ?   ?   R . n 
A 1 45  SER 45  -11 ?   ?   ?   R . n 
A 1 46  SER 46  -10 ?   ?   ?   R . n 
A 1 47  SER 47  -9  ?   ?   ?   R . n 
A 1 48  LEU 48  -8  ?   ?   ?   R . n 
A 1 49  GLU 49  -7  ?   ?   ?   R . n 
A 1 50  VAL 50  -6  ?   ?   ?   R . n 
A 1 51  LEU 51  -5  ?   ?   ?   R . n 
A 1 52  PHE 52  -4  ?   ?   ?   R . n 
A 1 53  GLN 53  -3  ?   ?   ?   R . n 
A 1 54  GLY 54  -2  ?   ?   ?   R . n 
A 1 55  PRO 55  -1  ?   ?   ?   R . n 
A 1 56  GLY 56  0   ?   ?   ?   R . n 
A 1 57  SER 57  1   ?   ?   ?   R . n 
A 1 58  VAL 58  2   ?   ?   ?   R . n 
A 1 59  LEU 59  3   ?   ?   ?   R . n 
A 1 60  GLU 60  4   ?   ?   ?   R . n 
A 1 61  VAL 61  5   ?   ?   ?   R . n 
A 1 62  SER 62  6   ?   ?   ?   R . n 
A 1 63  ASP 63  7   ?   ?   ?   R . n 
A 1 64  HIS 64  8   ?   ?   ?   R . n 
A 1 65  GLN 65  9   ?   ?   ?   R . n 
A 1 66  VAL 66  10  ?   ?   ?   R . n 
A 1 67  LEU 67  11  ?   ?   ?   R . n 
A 1 68  ASN 68  12  ?   ?   ?   R . n 
A 1 69  ASP 69  13  ?   ?   ?   R . n 
A 1 70  ALA 70  14  ?   ?   ?   R . n 
A 1 71  GLU 71  15  ?   ?   ?   R . n 
A 1 72  VAL 72  16  ?   ?   ?   R . n 
A 1 73  ALA 73  17  ?   ?   ?   R . n 
A 1 74  ALA 74  18  ?   ?   ?   R . n 
A 1 75  LEU 75  19  ?   ?   ?   R . n 
A 1 76  LEU 76  20  ?   ?   ?   R . n 
A 1 77  GLU 77  21  ?   ?   ?   R . n 
A 1 78  ASN 78  22  ?   ?   ?   R . n 
A 1 79  PHE 79  23  ?   ?   ?   R . n 
A 1 80  SER 80  24  ?   ?   ?   R . n 
A 1 81  SER 81  25  ?   ?   ?   R . n 
A 1 82  SER 82  26  ?   ?   ?   R . n 
A 1 83  TYR 83  27  ?   ?   ?   R . n 
A 1 84  ASP 84  28  ?   ?   ?   R . n 
A 1 85  TYR 85  29  ?   ?   ?   R . n 
A 1 86  GLY 86  30  ?   ?   ?   R . n 
A 1 87  GLU 87  31  ?   ?   ?   R . n 
A 1 88  ASN 88  32  ?   ?   ?   R . n 
A 1 89  GLU 89  33  ?   ?   ?   R . n 
A 1 90  SER 90  34  ?   ?   ?   R . n 
A 1 91  ASP 91  35  ?   ?   ?   R . n 
A 1 92  SER 92  36  ?   ?   ?   R . n 
A 1 93  CYS 93  37  ?   ?   ?   R . n 
A 1 94  CYS 94  38  ?   ?   ?   R . n 
A 1 95  THR 95  39  ?   ?   ?   R . n 
A 1 96  SER 96  40  ?   ?   ?   R . n 
A 1 97  PRO 97  41  ?   ?   ?   R . n 
A 1 98  PRO 98  42  ?   ?   ?   R . n 
A 1 99  CYS 99  43  ?   ?   ?   R . n 
A 1 100 PRO 100 44  ?   ?   ?   R . n 
A 1 101 GLN 101 45  ?   ?   ?   R . n 
A 1 102 ASP 102 46  ?   ?   ?   R . n 
A 1 103 PHE 103 47  ?   ?   ?   R . n 
A 1 104 SER 104 48  ?   ?   ?   R . n 
A 1 105 LEU 105 49  ?   ?   ?   R . n 
A 1 106 ASN 106 50  ?   ?   ?   R . n 
A 1 107 PHE 107 51  ?   ?   ?   R . n 
A 1 108 ASP 108 52  ?   ?   ?   R . n 
A 1 109 ARG 109 53  ?   ?   ?   R . n 
A 1 110 ALA 110 54  ?   ?   ?   R . n 
A 1 111 PHE 111 55  ?   ?   ?   R . n 
A 1 112 LEU 112 56  ?   ?   ?   R . n 
A 1 113 PRO 113 57  57  PRO PRO R . n 
A 1 114 ALA 114 58  58  ALA ALA R . n 
A 1 115 LEU 115 59  59  LEU LEU R . n 
A 1 116 TYR 116 60  60  TYR TYR R . n 
A 1 117 SER 117 61  61  SER SER R . n 
A 1 118 LEU 118 62  62  LEU LEU R . n 
A 1 119 LEU 119 63  63  LEU LEU R . n 
A 1 120 PHE 120 64  64  PHE PHE R . n 
A 1 121 LEU 121 65  65  LEU LEU R . n 
A 1 122 LEU 122 66  66  LEU LEU R . n 
A 1 123 GLY 123 67  67  GLY GLY R . n 
A 1 124 LEU 124 68  68  LEU LEU R . n 
A 1 125 LEU 125 69  69  LEU LEU R . n 
A 1 126 GLY 126 70  70  GLY GLY R . n 
A 1 127 ASN 127 71  71  ASN ASN R . n 
A 1 128 GLY 128 72  72  GLY GLY R . n 
A 1 129 ALA 129 73  73  ALA ALA R . n 
A 1 130 VAL 130 74  74  VAL VAL R . n 
A 1 131 ALA 131 75  75  ALA ALA R . n 
A 1 132 ALA 132 76  76  ALA ALA R . n 
A 1 133 VAL 133 77  77  VAL VAL R . n 
A 1 134 LEU 134 78  78  LEU LEU R . n 
A 1 135 LEU 135 79  79  LEU LEU R . n 
A 1 136 SER 136 80  80  SER SER R . n 
A 1 137 ARG 137 81  81  ARG ARG R . n 
A 1 138 ARG 138 82  82  ARG ARG R . n 
A 1 139 THR 139 83  83  THR THR R . n 
A 1 140 ALA 140 84  84  ALA ALA R . n 
A 1 141 LEU 141 85  85  LEU LEU R . n 
A 1 142 SER 142 86  86  SER SER R . n 
A 1 143 SER 143 87  87  SER SER R . n 
A 1 144 THR 144 88  88  THR THR R . n 
A 1 145 ASP 145 89  89  ASP ASP R . n 
A 1 146 THR 146 90  90  THR THR R . n 
A 1 147 PHE 147 91  91  PHE PHE R . n 
A 1 148 LEU 148 92  92  LEU LEU R . n 
A 1 149 LEU 149 93  93  LEU LEU R . n 
A 1 150 HIS 150 94  94  HIS HIS R . n 
A 1 151 LEU 151 95  95  LEU LEU R . n 
A 1 152 ALA 152 96  96  ALA ALA R . n 
A 1 153 VAL 153 97  97  VAL VAL R . n 
A 1 154 ALA 154 98  98  ALA ALA R . n 
A 1 155 ASP 155 99  99  ASP ASP R . n 
A 1 156 THR 156 100 100 THR THR R . n 
A 1 157 LEU 157 101 101 LEU LEU R . n 
A 1 158 LEU 158 102 102 LEU LEU R . n 
A 1 159 VAL 159 103 103 VAL VAL R . n 
A 1 160 LEU 160 104 104 LEU LEU R . n 
A 1 161 THR 161 105 105 THR THR R . n 
A 1 162 LEU 162 106 106 LEU LEU R . n 
A 1 163 PRO 163 107 107 PRO PRO R . n 
A 1 164 LEU 164 108 108 LEU LEU R . n 
A 1 165 TRP 165 109 109 TRP TRP R . n 
A 1 166 ALA 166 110 110 ALA ALA R . n 
A 1 167 VAL 167 111 111 VAL VAL R . n 
A 1 168 ASP 168 112 112 ASP ASP R . n 
A 1 169 ALA 169 113 113 ALA ALA R . n 
A 1 170 ALA 170 114 114 ALA ALA R . n 
A 1 171 VAL 171 115 115 VAL VAL R . n 
A 1 172 GLN 172 116 116 GLN GLN R . n 
A 1 173 TRP 173 117 117 TRP TRP R . n 
A 1 174 VAL 174 118 118 VAL VAL R . n 
A 1 175 PHE 175 119 119 PHE PHE R . n 
A 1 176 GLY 176 120 120 GLY GLY R . n 
A 1 177 SER 177 121 121 SER SER R . n 
A 1 178 GLY 178 122 122 GLY GLY R . n 
A 1 179 LEU 179 123 123 LEU LEU R . n 
A 1 180 CYS 180 124 124 CYS CYS R . n 
A 1 181 LYS 181 125 125 LYS LYS R . n 
A 1 182 VAL 182 126 126 VAL VAL R . n 
A 1 183 ALA 183 127 127 ALA ALA R . n 
A 1 184 GLY 184 128 128 GLY GLY R . n 
A 1 185 ALA 185 129 129 ALA ALA R . n 
A 1 186 LEU 186 130 130 LEU LEU R . n 
A 1 187 PHE 187 131 131 PHE PHE R . n 
A 1 188 ASN 188 132 132 ASN ASN R . n 
A 1 189 ILE 189 133 133 ILE ILE R . n 
A 1 190 ASN 190 134 134 ASN ASN R . n 
A 1 191 PHE 191 135 135 PHE PHE R . n 
A 1 192 TYR 192 136 136 TYR TYR R . n 
A 1 193 ALA 193 137 137 ALA ALA R . n 
A 1 194 GLY 194 138 138 GLY GLY R . n 
A 1 195 ALA 195 139 139 ALA ALA R . n 
A 1 196 LEU 196 140 140 LEU LEU R . n 
A 1 197 LEU 197 141 141 LEU LEU R . n 
A 1 198 LEU 198 142 142 LEU LEU R . n 
A 1 199 ALA 199 143 143 ALA ALA R . n 
A 1 200 CYS 200 144 144 CYS CYS R . n 
A 1 201 ILE 201 145 145 ILE ILE R . n 
A 1 202 SER 202 146 146 SER SER R . n 
A 1 203 PHE 203 147 147 PHE PHE R . n 
A 1 204 ASP 204 148 148 ASP ASP R . n 
A 1 205 ARG 205 149 149 ARG ARG R . n 
A 1 206 TYR 206 150 150 TYR TYR R . n 
A 1 207 LEU 207 151 151 LEU LEU R . n 
A 1 208 ASN 208 152 152 ASN ASN R . n 
A 1 209 ILE 209 153 153 ILE ILE R . n 
A 1 210 VAL 210 154 154 VAL VAL R . n 
A 1 211 HIS 211 155 155 HIS HIS R . n 
A 1 212 ALA 212 156 156 ALA ALA R . n 
A 1 213 THR 213 157 157 THR THR R . n 
A 1 214 GLN 214 158 158 GLN GLN R . n 
A 1 215 LEU 215 159 159 LEU LEU R . n 
A 1 216 TYR 216 160 160 TYR TYR R . n 
A 1 217 ARG 217 161 161 ARG ARG R . n 
A 1 218 ARG 218 162 162 ARG ARG R . n 
A 1 219 GLY 219 163 163 GLY GLY R . n 
A 1 220 PRO 220 164 164 PRO PRO R . n 
A 1 221 PRO 221 165 165 PRO PRO R . n 
A 1 222 ALA 222 166 166 ALA ALA R . n 
A 1 223 ARG 223 167 167 ARG ARG R . n 
A 1 224 VAL 224 168 168 VAL VAL R . n 
A 1 225 THR 225 169 169 THR THR R . n 
A 1 226 LEU 226 170 170 LEU LEU R . n 
A 1 227 THR 227 171 171 THR THR R . n 
A 1 228 CYS 228 172 172 CYS CYS R . n 
A 1 229 LEU 229 173 173 LEU LEU R . n 
A 1 230 ALA 230 174 174 ALA ALA R . n 
A 1 231 VAL 231 175 175 VAL VAL R . n 
A 1 232 TRP 232 176 176 TRP TRP R . n 
A 1 233 GLY 233 177 177 GLY GLY R . n 
A 1 234 LEU 234 178 178 LEU LEU R . n 
A 1 235 CYS 235 179 179 CYS CYS R . n 
A 1 236 LEU 236 180 180 LEU LEU R . n 
A 1 237 LEU 237 181 181 LEU LEU R . n 
A 1 238 PHE 238 182 182 PHE PHE R . n 
A 1 239 ALA 239 183 183 ALA ALA R . n 
A 1 240 LEU 240 184 184 LEU LEU R . n 
A 1 241 PRO 241 185 185 PRO PRO R . n 
A 1 242 ASP 242 186 186 ASP ASP R . n 
A 1 243 PHE 243 187 187 PHE PHE R . n 
A 1 244 ILE 244 188 188 ILE ILE R . n 
A 1 245 PHE 245 189 189 PHE PHE R . n 
A 1 246 LEU 246 190 190 LEU LEU R . n 
A 1 247 SER 247 191 191 SER SER R . n 
A 1 248 ALA 248 192 192 ALA ALA R . n 
A 1 249 HIS 249 193 193 HIS HIS R . n 
A 1 250 HIS 250 194 194 HIS HIS R . n 
A 1 251 ASP 251 195 195 ASP ASP R . n 
A 1 252 GLU 252 196 196 GLU GLU R . n 
A 1 253 ARG 253 197 197 ARG ARG R . n 
A 1 254 LEU 254 198 198 LEU LEU R . n 
A 1 255 ASN 255 199 199 ASN ASN R . n 
A 1 256 ALA 256 200 200 ALA ALA R . n 
A 1 257 THR 257 201 201 THR THR R . n 
A 1 258 HIS 258 202 202 HIS HIS R . n 
A 1 259 CYS 259 203 203 CYS CYS R . n 
A 1 260 GLN 260 204 204 GLN GLN R . n 
A 1 261 TYR 261 205 205 TYR TYR R . n 
A 1 262 ASN 262 206 206 ASN ASN R . n 
A 1 263 PHE 263 207 207 PHE PHE R . n 
A 1 264 PRO 264 208 208 PRO PRO R . n 
A 1 265 GLN 265 209 209 GLN GLN R . n 
A 1 266 VAL 266 210 210 VAL VAL R . n 
A 1 267 GLY 267 211 211 GLY GLY R . n 
A 1 268 ARG 268 212 212 ARG ARG R . n 
A 1 269 THR 269 213 213 THR THR R . n 
A 1 270 ALA 270 214 214 ALA ALA R . n 
A 1 271 LEU 271 215 215 LEU LEU R . n 
A 1 272 ARG 272 216 216 ARG ARG R . n 
A 1 273 VAL 273 217 217 VAL VAL R . n 
A 1 274 LEU 274 218 218 LEU LEU R . n 
A 1 275 GLN 275 219 219 GLN GLN R . n 
A 1 276 LEU 276 220 220 LEU LEU R . n 
A 1 277 VAL 277 221 221 VAL VAL R . n 
A 1 278 ALA 278 222 222 ALA ALA R . n 
A 1 279 GLY 279 223 223 GLY GLY R . n 
A 1 280 PHE 280 224 224 PHE PHE R . n 
A 1 281 LEU 281 225 225 LEU LEU R . n 
A 1 282 LEU 282 226 226 LEU LEU R . n 
A 1 283 PRO 283 227 227 PRO PRO R . n 
A 1 284 LEU 284 228 228 LEU LEU R . n 
A 1 285 LEU 285 229 229 LEU LEU R . n 
A 1 286 VAL 286 230 230 VAL VAL R . n 
A 1 287 MET 287 231 231 MET MET R . n 
A 1 288 ALA 288 232 232 ALA ALA R . n 
A 1 289 TYR 289 233 233 TYR TYR R . n 
A 1 290 CYS 290 234 234 CYS CYS R . n 
A 1 291 TYR 291 235 235 TYR TYR R . n 
A 1 292 ALA 292 236 236 ALA ALA R . n 
A 1 293 HIS 293 237 237 HIS HIS R . n 
A 1 294 ILE 294 238 238 ILE ILE R . n 
A 1 295 LEU 295 239 239 LEU LEU R . n 
A 1 296 ALA 296 240 240 ALA ALA R . n 
A 1 297 VAL 297 241 241 VAL VAL R . n 
A 1 298 LEU 298 242 242 LEU LEU R . n 
A 1 299 LEU 299 243 243 LEU LEU R . n 
A 1 300 VAL 300 244 244 VAL VAL R . n 
A 1 301 SER 301 245 245 SER SER R . n 
A 1 302 ARG 302 246 246 ARG ARG R . n 
A 1 303 GLY 303 247 247 GLY GLY R . n 
A 1 304 GLN 304 248 248 GLN GLN R . n 
A 1 305 ARG 305 249 249 ARG ARG R . n 
A 1 306 ARG 306 250 250 ARG ARG R . n 
A 1 307 LEU 307 251 251 LEU LEU R . n 
A 1 308 ARG 308 252 252 ARG ARG R . n 
A 1 309 ALA 309 253 253 ALA ALA R . n 
A 1 310 MET 310 254 254 MET MET R . n 
A 1 311 ARG 311 255 255 ARG ARG R . n 
A 1 312 LEU 312 256 256 LEU LEU R . n 
A 1 313 VAL 313 257 257 VAL VAL R . n 
A 1 314 VAL 314 258 258 VAL VAL R . n 
A 1 315 VAL 315 259 259 VAL VAL R . n 
A 1 316 VAL 316 260 260 VAL VAL R . n 
A 1 317 VAL 317 261 261 VAL VAL R . n 
A 1 318 VAL 318 262 262 VAL VAL R . n 
A 1 319 ALA 319 263 263 ALA ALA R . n 
A 1 320 PHE 320 264 264 PHE PHE R . n 
A 1 321 ALA 321 265 265 ALA ALA R . n 
A 1 322 LEU 322 266 266 LEU LEU R . n 
A 1 323 CYS 323 267 267 CYS CYS R . n 
A 1 324 TRP 324 268 268 TRP TRP R . n 
A 1 325 THR 325 269 269 THR THR R . n 
A 1 326 PRO 326 270 270 PRO PRO R . n 
A 1 327 TYR 327 271 271 TYR TYR R . n 
A 1 328 HIS 328 272 272 HIS HIS R . n 
A 1 329 LEU 329 273 273 LEU LEU R . n 
A 1 330 VAL 330 274 274 VAL VAL R . n 
A 1 331 VAL 331 275 275 VAL VAL R . n 
A 1 332 LEU 332 276 276 LEU LEU R . n 
A 1 333 VAL 333 277 277 VAL VAL R . n 
A 1 334 ASP 334 278 278 ASP ASP R . n 
A 1 335 ILE 335 279 279 ILE ILE R . n 
A 1 336 LEU 336 280 280 LEU LEU R . n 
A 1 337 MET 337 281 281 MET MET R . n 
A 1 338 ASP 338 282 282 ASP ASP R . n 
A 1 339 LEU 339 283 283 LEU LEU R . n 
A 1 340 GLY 340 284 284 GLY GLY R . n 
A 1 341 ALA 341 285 285 ALA ALA R . n 
A 1 342 LEU 342 286 286 LEU LEU R . n 
A 1 343 ALA 343 287 287 ALA ALA R . n 
A 1 344 ARG 344 288 288 ARG ARG R . n 
A 1 345 ASN 345 289 289 ASN ASN R . n 
A 1 346 CYS 346 290 290 CYS CYS R . n 
A 1 347 GLY 347 291 291 GLY GLY R . n 
A 1 348 ARG 348 292 292 ARG ARG R . n 
A 1 349 GLU 349 293 293 GLU GLU R . n 
A 1 350 SER 350 294 294 SER SER R . n 
A 1 351 ARG 351 295 295 ARG ARG R . n 
A 1 352 VAL 352 296 296 VAL VAL R . n 
A 1 353 ASP 353 297 297 ASP ASP R . n 
A 1 354 VAL 354 298 298 VAL VAL R . n 
A 1 355 ALA 355 299 299 ALA ALA R . n 
A 1 356 LYS 356 300 300 LYS LYS R . n 
A 1 357 SER 357 301 301 SER SER R . n 
A 1 358 VAL 358 302 302 VAL VAL R . n 
A 1 359 THR 359 303 303 THR THR R . n 
A 1 360 SER 360 304 304 SER SER R . n 
A 1 361 GLY 361 305 305 GLY GLY R . n 
A 1 362 LEU 362 306 306 LEU LEU R . n 
A 1 363 GLY 363 307 307 GLY GLY R . n 
A 1 364 TYR 364 308 308 TYR TYR R . n 
A 1 365 MET 365 309 309 MET MET R . n 
A 1 366 HIS 366 310 310 HIS HIS R . n 
A 1 367 CYS 367 311 311 CYS CYS R . n 
A 1 368 CYS 368 312 312 CYS CYS R . n 
A 1 369 LEU 369 313 313 LEU LEU R . n 
A 1 370 ASN 370 314 314 ASN ASN R . n 
A 1 371 PRO 371 315 315 PRO PRO R . n 
A 1 372 LEU 372 316 316 LEU LEU R . n 
A 1 373 LEU 373 317 317 LEU LEU R . n 
A 1 374 TYR 374 318 318 TYR TYR R . n 
A 1 375 ALA 375 319 319 ALA ALA R . n 
A 1 376 PHE 376 320 320 PHE PHE R . n 
A 1 377 VAL 377 321 321 VAL VAL R . n 
A 1 378 GLY 378 322 322 GLY GLY R . n 
A 1 379 VAL 379 323 323 VAL VAL R . n 
A 1 380 LYS 380 324 324 LYS LYS R . n 
A 1 381 PHE 381 325 325 PHE PHE R . n 
A 1 382 ARG 382 326 326 ARG ARG R . n 
A 1 383 GLU 383 327 327 GLU GLU R . n 
A 1 384 ARG 384 328 328 ARG ARG R . n 
A 1 385 MET 385 329 329 MET MET R . n 
A 1 386 TRP 386 330 330 TRP TRP R . n 
A 1 387 MET 387 331 331 MET MET R . n 
A 1 388 LEU 388 332 332 LEU LEU R . n 
A 1 389 LEU 389 333 333 LEU LEU R . n 
A 1 390 LEU 390 334 334 LEU LEU R . n 
A 1 391 ARG 391 335 335 ARG ARG R . n 
A 1 392 LEU 392 336 ?   ?   ?   R . n 
A 1 393 GLY 393 337 ?   ?   ?   R . n 
A 1 394 CYS 394 338 ?   ?   ?   R . n 
A 1 395 PRO 395 339 ?   ?   ?   R . n 
A 1 396 ASN 396 340 ?   ?   ?   R . n 
A 1 397 GLN 397 341 ?   ?   ?   R . n 
A 1 398 ARG 398 342 ?   ?   ?   R . n 
A 1 399 GLY 399 343 ?   ?   ?   R . n 
A 1 400 LEU 400 344 ?   ?   ?   R . n 
A 1 401 GLN 401 345 ?   ?   ?   R . n 
A 1 402 ARG 402 346 ?   ?   ?   R . n 
A 1 403 GLN 403 347 ?   ?   ?   R . n 
A 1 404 PRO 404 348 ?   ?   ?   R . n 
A 1 405 SER 405 349 ?   ?   ?   R . n 
A 1 406 SER 406 350 ?   ?   ?   R . n 
A 1 407 SER 407 351 ?   ?   ?   R . n 
A 1 408 ARG 408 352 ?   ?   ?   R . n 
A 1 409 ARG 409 353 ?   ?   ?   R . n 
A 1 410 ASP 410 354 ?   ?   ?   R . n 
A 1 411 SER 411 355 ?   ?   ?   R . n 
A 1 412 SER 412 356 ?   ?   ?   R . n 
A 1 413 TRP 413 357 ?   ?   ?   R . n 
A 1 414 SER 414 358 ?   ?   ?   R . n 
A 1 415 GLU 415 359 ?   ?   ?   R . n 
A 1 416 THR 416 360 ?   ?   ?   R . n 
A 1 417 SER 417 361 ?   ?   ?   R . n 
A 1 418 GLU 418 362 ?   ?   ?   R . n 
A 1 419 ALA 419 363 ?   ?   ?   R . n 
A 1 420 SER 420 364 ?   ?   ?   R . n 
A 1 421 TYR 421 365 ?   ?   ?   R . n 
A 1 422 SER 422 366 ?   ?   ?   R . n 
A 1 423 GLY 423 367 ?   ?   ?   R . n 
A 1 424 LEU 424 368 ?   ?   ?   R . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LW2 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LW2 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          A1LW2 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     401 
_pdbx_nonpoly_scheme.auth_seq_num    401 
_pdbx_nonpoly_scheme.pdb_mon_id      A1LW2 
_pdbx_nonpoly_scheme.auth_mon_id     LIG 
_pdbx_nonpoly_scheme.pdb_strand_id   R 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Y0H 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Y0H 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Y0H 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8Y0H 
_struct.title                        'Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Y0H 
_struct_keywords.text            'GPCR, Arrestin, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CXCR3_HUMAN 
_struct_ref.pdbx_db_accession          P49682 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;VLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSR
RTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR
RGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAV
LLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV
GVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Y0H 
_struct_ref_seq.pdbx_strand_id                R 
_struct_ref_seq.seq_align_beg                 58 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 424 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P49682 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  368 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       368 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8Y0H MET R 1  ? UNP P49682 ? ? 'initiating methionine' -55 1  
1 8Y0H GLY R 2  ? UNP P49682 ? ? 'expression tag'        -54 2  
1 8Y0H LYS R 3  ? UNP P49682 ? ? 'expression tag'        -53 3  
1 8Y0H THR R 4  ? UNP P49682 ? ? 'expression tag'        -52 4  
1 8Y0H ILE R 5  ? UNP P49682 ? ? 'expression tag'        -51 5  
1 8Y0H ILE R 6  ? UNP P49682 ? ? 'expression tag'        -50 6  
1 8Y0H ALA R 7  ? UNP P49682 ? ? 'expression tag'        -49 7  
1 8Y0H LEU R 8  ? UNP P49682 ? ? 'expression tag'        -48 8  
1 8Y0H SER R 9  ? UNP P49682 ? ? 'expression tag'        -47 9  
1 8Y0H TYR R 10 ? UNP P49682 ? ? 'expression tag'        -46 10 
1 8Y0H ILE R 11 ? UNP P49682 ? ? 'expression tag'        -45 11 
1 8Y0H PHE R 12 ? UNP P49682 ? ? 'expression tag'        -44 12 
1 8Y0H CYS R 13 ? UNP P49682 ? ? 'expression tag'        -43 13 
1 8Y0H LEU R 14 ? UNP P49682 ? ? 'expression tag'        -42 14 
1 8Y0H VAL R 15 ? UNP P49682 ? ? 'expression tag'        -41 15 
1 8Y0H PHE R 16 ? UNP P49682 ? ? 'expression tag'        -40 16 
1 8Y0H ALA R 17 ? UNP P49682 ? ? 'expression tag'        -39 17 
1 8Y0H ASP R 18 ? UNP P49682 ? ? 'expression tag'        -38 18 
1 8Y0H TYR R 19 ? UNP P49682 ? ? 'expression tag'        -37 19 
1 8Y0H LYS R 20 ? UNP P49682 ? ? 'expression tag'        -36 20 
1 8Y0H ASP R 21 ? UNP P49682 ? ? 'expression tag'        -35 21 
1 8Y0H ASP R 22 ? UNP P49682 ? ? 'expression tag'        -34 22 
1 8Y0H ASP R 23 ? UNP P49682 ? ? 'expression tag'        -33 23 
1 8Y0H ASP R 24 ? UNP P49682 ? ? 'expression tag'        -32 24 
1 8Y0H ALA R 25 ? UNP P49682 ? ? 'expression tag'        -31 25 
1 8Y0H ALA R 26 ? UNP P49682 ? ? 'expression tag'        -30 26 
1 8Y0H ASN R 27 ? UNP P49682 ? ? 'expression tag'        -29 27 
1 8Y0H PHE R 28 ? UNP P49682 ? ? 'expression tag'        -28 28 
1 8Y0H THR R 29 ? UNP P49682 ? ? 'expression tag'        -27 29 
1 8Y0H PRO R 30 ? UNP P49682 ? ? 'expression tag'        -26 30 
1 8Y0H VAL R 31 ? UNP P49682 ? ? 'expression tag'        -25 31 
1 8Y0H ASN R 32 ? UNP P49682 ? ? 'expression tag'        -24 32 
1 8Y0H GLY R 33 ? UNP P49682 ? ? 'expression tag'        -23 33 
1 8Y0H SER R 34 ? UNP P49682 ? ? 'expression tag'        -22 34 
1 8Y0H SER R 35 ? UNP P49682 ? ? 'expression tag'        -21 35 
1 8Y0H GLY R 36 ? UNP P49682 ? ? 'expression tag'        -20 36 
1 8Y0H ASN R 37 ? UNP P49682 ? ? 'expression tag'        -19 37 
1 8Y0H GLN R 38 ? UNP P49682 ? ? 'expression tag'        -18 38 
1 8Y0H SER R 39 ? UNP P49682 ? ? 'expression tag'        -17 39 
1 8Y0H VAL R 40 ? UNP P49682 ? ? 'expression tag'        -16 40 
1 8Y0H ARG R 41 ? UNP P49682 ? ? 'expression tag'        -15 41 
1 8Y0H LEU R 42 ? UNP P49682 ? ? 'expression tag'        -14 42 
1 8Y0H VAL R 43 ? UNP P49682 ? ? 'expression tag'        -13 43 
1 8Y0H THR R 44 ? UNP P49682 ? ? 'expression tag'        -12 44 
1 8Y0H SER R 45 ? UNP P49682 ? ? 'expression tag'        -11 45 
1 8Y0H SER R 46 ? UNP P49682 ? ? 'expression tag'        -10 46 
1 8Y0H SER R 47 ? UNP P49682 ? ? 'expression tag'        -9  47 
1 8Y0H LEU R 48 ? UNP P49682 ? ? 'expression tag'        -8  48 
1 8Y0H GLU R 49 ? UNP P49682 ? ? 'expression tag'        -7  49 
1 8Y0H VAL R 50 ? UNP P49682 ? ? 'expression tag'        -6  50 
1 8Y0H LEU R 51 ? UNP P49682 ? ? 'expression tag'        -5  51 
1 8Y0H PHE R 52 ? UNP P49682 ? ? 'expression tag'        -4  52 
1 8Y0H GLN R 53 ? UNP P49682 ? ? 'expression tag'        -3  53 
1 8Y0H GLY R 54 ? UNP P49682 ? ? 'expression tag'        -2  54 
1 8Y0H PRO R 55 ? UNP P49682 ? ? 'expression tag'        -1  55 
1 8Y0H GLY R 56 ? UNP P49682 ? ? 'expression tag'        0   56 
1 8Y0H SER R 57 ? UNP P49682 ? ? 'expression tag'        1   57 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 113 ? LEU A 135 ? PRO R 57  LEU R 79  1 ? 23 
HELX_P HELX_P2  AA2 SER A 142 ? LEU A 160 ? SER R 86  LEU R 104 1 ? 19 
HELX_P HELX_P3  AA3 THR A 161 ? VAL A 171 ? THR R 105 VAL R 115 1 ? 11 
HELX_P HELX_P4  AA4 PHE A 175 ? VAL A 210 ? PHE R 119 VAL R 154 1 ? 36 
HELX_P HELX_P5  AA5 HIS A 211 ? TYR A 216 ? HIS R 155 TYR R 160 5 ? 6  
HELX_P HELX_P6  AA6 VAL A 224 ? PHE A 245 ? VAL R 168 PHE R 189 1 ? 22 
HELX_P HELX_P7  AA7 PRO A 264 ? PHE A 280 ? PRO R 208 PHE R 224 1 ? 17 
HELX_P HELX_P8  AA8 PHE A 280 ? LEU A 299 ? PHE R 224 LEU R 243 1 ? 20 
HELX_P HELX_P9  AA9 ARG A 305 ? LEU A 339 ? ARG R 249 LEU R 283 1 ? 35 
HELX_P HELX_P10 AB1 ASN A 345 ? ALA A 375 ? ASN R 289 ALA R 319 1 ? 31 
HELX_P HELX_P11 AB2 GLY A 378 ? ARG A 391 ? GLY R 322 ARG R 335 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            180 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            259 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            R 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             124 
_struct_conn.ptnr2_auth_asym_id            R 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             203 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.031 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       180 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      259 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       R 
_pdbx_modification_feature.auth_seq_id                        124 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      R 
_pdbx_modification_feature.modified_residue_auth_seq_id       203 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 247 ? HIS A 250 ? SER R 191 HIS R 194 
AA1 2 THR A 257 ? GLN A 260 ? THR R 201 GLN R 204 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   SER 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    247 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    SER 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    R 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     191 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   GLN 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    260 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    GLN 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    R 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     204 
# 
_pdbx_entry_details.entry_id                   8Y0H 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8Y0H 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'FLEXIBLE FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  . 
_em_3d_fitting_list.pdb_chain_id                  . 
_em_3d_fitting_list.pdb_chain_residue_range       . 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   AlphaFold 
_em_3d_fitting_list.type                          'in silico model' 
_em_3d_fitting_list.accession_code                ? 
_em_3d_fitting_list.initial_refinement_model_id   ? 
# 
_em_3d_reconstruction.entry_id                    8Y0H 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.53 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               150213 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'C-X-C chemokine receptor type 3 in complex with VUF11418' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8Y0H 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_vitrification.entry_id              8Y0H 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8Y0H 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 R MET -55 ? A MET 1   
2   1 Y 1 R GLY -54 ? A GLY 2   
3   1 Y 1 R LYS -53 ? A LYS 3   
4   1 Y 1 R THR -52 ? A THR 4   
5   1 Y 1 R ILE -51 ? A ILE 5   
6   1 Y 1 R ILE -50 ? A ILE 6   
7   1 Y 1 R ALA -49 ? A ALA 7   
8   1 Y 1 R LEU -48 ? A LEU 8   
9   1 Y 1 R SER -47 ? A SER 9   
10  1 Y 1 R TYR -46 ? A TYR 10  
11  1 Y 1 R ILE -45 ? A ILE 11  
12  1 Y 1 R PHE -44 ? A PHE 12  
13  1 Y 1 R CYS -43 ? A CYS 13  
14  1 Y 1 R LEU -42 ? A LEU 14  
15  1 Y 1 R VAL -41 ? A VAL 15  
16  1 Y 1 R PHE -40 ? A PHE 16  
17  1 Y 1 R ALA -39 ? A ALA 17  
18  1 Y 1 R ASP -38 ? A ASP 18  
19  1 Y 1 R TYR -37 ? A TYR 19  
20  1 Y 1 R LYS -36 ? A LYS 20  
21  1 Y 1 R ASP -35 ? A ASP 21  
22  1 Y 1 R ASP -34 ? A ASP 22  
23  1 Y 1 R ASP -33 ? A ASP 23  
24  1 Y 1 R ASP -32 ? A ASP 24  
25  1 Y 1 R ALA -31 ? A ALA 25  
26  1 Y 1 R ALA -30 ? A ALA 26  
27  1 Y 1 R ASN -29 ? A ASN 27  
28  1 Y 1 R PHE -28 ? A PHE 28  
29  1 Y 1 R THR -27 ? A THR 29  
30  1 Y 1 R PRO -26 ? A PRO 30  
31  1 Y 1 R VAL -25 ? A VAL 31  
32  1 Y 1 R ASN -24 ? A ASN 32  
33  1 Y 1 R GLY -23 ? A GLY 33  
34  1 Y 1 R SER -22 ? A SER 34  
35  1 Y 1 R SER -21 ? A SER 35  
36  1 Y 1 R GLY -20 ? A GLY 36  
37  1 Y 1 R ASN -19 ? A ASN 37  
38  1 Y 1 R GLN -18 ? A GLN 38  
39  1 Y 1 R SER -17 ? A SER 39  
40  1 Y 1 R VAL -16 ? A VAL 40  
41  1 Y 1 R ARG -15 ? A ARG 41  
42  1 Y 1 R LEU -14 ? A LEU 42  
43  1 Y 1 R VAL -13 ? A VAL 43  
44  1 Y 1 R THR -12 ? A THR 44  
45  1 Y 1 R SER -11 ? A SER 45  
46  1 Y 1 R SER -10 ? A SER 46  
47  1 Y 1 R SER -9  ? A SER 47  
48  1 Y 1 R LEU -8  ? A LEU 48  
49  1 Y 1 R GLU -7  ? A GLU 49  
50  1 Y 1 R VAL -6  ? A VAL 50  
51  1 Y 1 R LEU -5  ? A LEU 51  
52  1 Y 1 R PHE -4  ? A PHE 52  
53  1 Y 1 R GLN -3  ? A GLN 53  
54  1 Y 1 R GLY -2  ? A GLY 54  
55  1 Y 1 R PRO -1  ? A PRO 55  
56  1 Y 1 R GLY 0   ? A GLY 56  
57  1 Y 1 R SER 1   ? A SER 57  
58  1 Y 1 R VAL 2   ? A VAL 58  
59  1 Y 1 R LEU 3   ? A LEU 59  
60  1 Y 1 R GLU 4   ? A GLU 60  
61  1 Y 1 R VAL 5   ? A VAL 61  
62  1 Y 1 R SER 6   ? A SER 62  
63  1 Y 1 R ASP 7   ? A ASP 63  
64  1 Y 1 R HIS 8   ? A HIS 64  
65  1 Y 1 R GLN 9   ? A GLN 65  
66  1 Y 1 R VAL 10  ? A VAL 66  
67  1 Y 1 R LEU 11  ? A LEU 67  
68  1 Y 1 R ASN 12  ? A ASN 68  
69  1 Y 1 R ASP 13  ? A ASP 69  
70  1 Y 1 R ALA 14  ? A ALA 70  
71  1 Y 1 R GLU 15  ? A GLU 71  
72  1 Y 1 R VAL 16  ? A VAL 72  
73  1 Y 1 R ALA 17  ? A ALA 73  
74  1 Y 1 R ALA 18  ? A ALA 74  
75  1 Y 1 R LEU 19  ? A LEU 75  
76  1 Y 1 R LEU 20  ? A LEU 76  
77  1 Y 1 R GLU 21  ? A GLU 77  
78  1 Y 1 R ASN 22  ? A ASN 78  
79  1 Y 1 R PHE 23  ? A PHE 79  
80  1 Y 1 R SER 24  ? A SER 80  
81  1 Y 1 R SER 25  ? A SER 81  
82  1 Y 1 R SER 26  ? A SER 82  
83  1 Y 1 R TYR 27  ? A TYR 83  
84  1 Y 1 R ASP 28  ? A ASP 84  
85  1 Y 1 R TYR 29  ? A TYR 85  
86  1 Y 1 R GLY 30  ? A GLY 86  
87  1 Y 1 R GLU 31  ? A GLU 87  
88  1 Y 1 R ASN 32  ? A ASN 88  
89  1 Y 1 R GLU 33  ? A GLU 89  
90  1 Y 1 R SER 34  ? A SER 90  
91  1 Y 1 R ASP 35  ? A ASP 91  
92  1 Y 1 R SER 36  ? A SER 92  
93  1 Y 1 R CYS 37  ? A CYS 93  
94  1 Y 1 R CYS 38  ? A CYS 94  
95  1 Y 1 R THR 39  ? A THR 95  
96  1 Y 1 R SER 40  ? A SER 96  
97  1 Y 1 R PRO 41  ? A PRO 97  
98  1 Y 1 R PRO 42  ? A PRO 98  
99  1 Y 1 R CYS 43  ? A CYS 99  
100 1 Y 1 R PRO 44  ? A PRO 100 
101 1 Y 1 R GLN 45  ? A GLN 101 
102 1 Y 1 R ASP 46  ? A ASP 102 
103 1 Y 1 R PHE 47  ? A PHE 103 
104 1 Y 1 R SER 48  ? A SER 104 
105 1 Y 1 R LEU 49  ? A LEU 105 
106 1 Y 1 R ASN 50  ? A ASN 106 
107 1 Y 1 R PHE 51  ? A PHE 107 
108 1 Y 1 R ASP 52  ? A ASP 108 
109 1 Y 1 R ARG 53  ? A ARG 109 
110 1 Y 1 R ALA 54  ? A ALA 110 
111 1 Y 1 R PHE 55  ? A PHE 111 
112 1 Y 1 R LEU 56  ? A LEU 112 
113 1 Y 1 R LEU 336 ? A LEU 392 
114 1 Y 1 R GLY 337 ? A GLY 393 
115 1 Y 1 R CYS 338 ? A CYS 394 
116 1 Y 1 R PRO 339 ? A PRO 395 
117 1 Y 1 R ASN 340 ? A ASN 396 
118 1 Y 1 R GLN 341 ? A GLN 397 
119 1 Y 1 R ARG 342 ? A ARG 398 
120 1 Y 1 R GLY 343 ? A GLY 399 
121 1 Y 1 R LEU 344 ? A LEU 400 
122 1 Y 1 R GLN 345 ? A GLN 401 
123 1 Y 1 R ARG 346 ? A ARG 402 
124 1 Y 1 R GLN 347 ? A GLN 403 
125 1 Y 1 R PRO 348 ? A PRO 404 
126 1 Y 1 R SER 349 ? A SER 405 
127 1 Y 1 R SER 350 ? A SER 406 
128 1 Y 1 R SER 351 ? A SER 407 
129 1 Y 1 R ARG 352 ? A ARG 408 
130 1 Y 1 R ARG 353 ? A ARG 409 
131 1 Y 1 R ASP 354 ? A ASP 410 
132 1 Y 1 R SER 355 ? A SER 411 
133 1 Y 1 R SER 356 ? A SER 412 
134 1 Y 1 R TRP 357 ? A TRP 413 
135 1 Y 1 R SER 358 ? A SER 414 
136 1 Y 1 R GLU 359 ? A GLU 415 
137 1 Y 1 R THR 360 ? A THR 416 
138 1 Y 1 R SER 361 ? A SER 417 
139 1 Y 1 R GLU 362 ? A GLU 418 
140 1 Y 1 R ALA 363 ? A ALA 419 
141 1 Y 1 R SER 364 ? A SER 420 
142 1 Y 1 R TYR 365 ? A TYR 421 
143 1 Y 1 R SER 366 ? A SER 422 
144 1 Y 1 R GLY 367 ? A GLY 423 
145 1 Y 1 R LEU 368 ? A LEU 424 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LW2 C4   C N N 1   
A1LW2 C5   C N N 2   
A1LW2 C6   C N N 3   
A1LW2 C7   C N R 4   
A1LW2 C8   C N N 5   
A1LW2 C13  C N N 6   
A1LW2 C15  C Y N 7   
A1LW2 C17  C Y N 8   
A1LW2 C20  C Y N 9   
A1LW2 C21  C Y N 10  
A1LW2 C22  C Y N 11  
A1LW2 C24  C Y N 12  
A1LW2 C1   C N N 13  
A1LW2 C11  C N N 14  
A1LW2 C12  C N N 15  
A1LW2 C14  C Y N 16  
A1LW2 C16  C Y N 17  
A1LW2 C18  C Y N 18  
A1LW2 C19  C Y N 19  
A1LW2 C2   C N N 20  
A1LW2 C23  C Y N 21  
A1LW2 C25  C Y N 22  
A1LW2 C27  C N N 23  
A1LW2 C3   C N S 24  
A1LW2 C9   C N N 25  
A1LW2 I26  I N N 26  
A1LW2 N10  N N N 27  
A1LW2 H1   H N N 28  
A1LW2 H2   H N N 29  
A1LW2 H3   H N N 30  
A1LW2 H6   H N N 31  
A1LW2 H7   H N N 32  
A1LW2 H8   H N N 33  
A1LW2 H9   H N N 34  
A1LW2 H10  H N N 35  
A1LW2 H11  H N N 36  
A1LW2 H12  H N N 37  
A1LW2 H13  H N N 38  
A1LW2 H14  H N N 39  
A1LW2 H15  H N N 40  
A1LW2 H16  H N N 41  
A1LW2 H17  H N N 42  
A1LW2 H18  H N N 43  
A1LW2 H19  H N N 44  
A1LW2 H20  H N N 45  
A1LW2 H21  H N N 46  
A1LW2 H22  H N N 47  
A1LW2 H23  H N N 48  
A1LW2 H24  H N N 49  
A1LW2 H25  H N N 50  
A1LW2 H26  H N N 51  
A1LW2 H27  H N N 52  
A1LW2 H28  H N N 53  
A1LW2 H29  H N N 54  
A1LW2 H30  H N N 55  
A1LW2 H31  H N N 56  
A1LW2 H32  H N N 57  
A1LW2 H33  H N N 58  
ALA   N    N N N 59  
ALA   CA   C N S 60  
ALA   C    C N N 61  
ALA   O    O N N 62  
ALA   CB   C N N 63  
ALA   OXT  O N N 64  
ALA   H    H N N 65  
ALA   H2   H N N 66  
ALA   HA   H N N 67  
ALA   HB1  H N N 68  
ALA   HB2  H N N 69  
ALA   HB3  H N N 70  
ALA   HXT  H N N 71  
ARG   N    N N N 72  
ARG   CA   C N S 73  
ARG   C    C N N 74  
ARG   O    O N N 75  
ARG   CB   C N N 76  
ARG   CG   C N N 77  
ARG   CD   C N N 78  
ARG   NE   N N N 79  
ARG   CZ   C N N 80  
ARG   NH1  N N N 81  
ARG   NH2  N N N 82  
ARG   OXT  O N N 83  
ARG   H    H N N 84  
ARG   H2   H N N 85  
ARG   HA   H N N 86  
ARG   HB2  H N N 87  
ARG   HB3  H N N 88  
ARG   HG2  H N N 89  
ARG   HG3  H N N 90  
ARG   HD2  H N N 91  
ARG   HD3  H N N 92  
ARG   HE   H N N 93  
ARG   HH11 H N N 94  
ARG   HH12 H N N 95  
ARG   HH21 H N N 96  
ARG   HH22 H N N 97  
ARG   HXT  H N N 98  
ASN   N    N N N 99  
ASN   CA   C N S 100 
ASN   C    C N N 101 
ASN   O    O N N 102 
ASN   CB   C N N 103 
ASN   CG   C N N 104 
ASN   OD1  O N N 105 
ASN   ND2  N N N 106 
ASN   OXT  O N N 107 
ASN   H    H N N 108 
ASN   H2   H N N 109 
ASN   HA   H N N 110 
ASN   HB2  H N N 111 
ASN   HB3  H N N 112 
ASN   HD21 H N N 113 
ASN   HD22 H N N 114 
ASN   HXT  H N N 115 
ASP   N    N N N 116 
ASP   CA   C N S 117 
ASP   C    C N N 118 
ASP   O    O N N 119 
ASP   CB   C N N 120 
ASP   CG   C N N 121 
ASP   OD1  O N N 122 
ASP   OD2  O N N 123 
ASP   OXT  O N N 124 
ASP   H    H N N 125 
ASP   H2   H N N 126 
ASP   HA   H N N 127 
ASP   HB2  H N N 128 
ASP   HB3  H N N 129 
ASP   HD2  H N N 130 
ASP   HXT  H N N 131 
CYS   N    N N N 132 
CYS   CA   C N R 133 
CYS   C    C N N 134 
CYS   O    O N N 135 
CYS   CB   C N N 136 
CYS   SG   S N N 137 
CYS   OXT  O N N 138 
CYS   H    H N N 139 
CYS   H2   H N N 140 
CYS   HA   H N N 141 
CYS   HB2  H N N 142 
CYS   HB3  H N N 143 
CYS   HG   H N N 144 
CYS   HXT  H N N 145 
GLN   N    N N N 146 
GLN   CA   C N S 147 
GLN   C    C N N 148 
GLN   O    O N N 149 
GLN   CB   C N N 150 
GLN   CG   C N N 151 
GLN   CD   C N N 152 
GLN   OE1  O N N 153 
GLN   NE2  N N N 154 
GLN   OXT  O N N 155 
GLN   H    H N N 156 
GLN   H2   H N N 157 
GLN   HA   H N N 158 
GLN   HB2  H N N 159 
GLN   HB3  H N N 160 
GLN   HG2  H N N 161 
GLN   HG3  H N N 162 
GLN   HE21 H N N 163 
GLN   HE22 H N N 164 
GLN   HXT  H N N 165 
GLU   N    N N N 166 
GLU   CA   C N S 167 
GLU   C    C N N 168 
GLU   O    O N N 169 
GLU   CB   C N N 170 
GLU   CG   C N N 171 
GLU   CD   C N N 172 
GLU   OE1  O N N 173 
GLU   OE2  O N N 174 
GLU   OXT  O N N 175 
GLU   H    H N N 176 
GLU   H2   H N N 177 
GLU   HA   H N N 178 
GLU   HB2  H N N 179 
GLU   HB3  H N N 180 
GLU   HG2  H N N 181 
GLU   HG3  H N N 182 
GLU   HE2  H N N 183 
GLU   HXT  H N N 184 
GLY   N    N N N 185 
GLY   CA   C N N 186 
GLY   C    C N N 187 
GLY   O    O N N 188 
GLY   OXT  O N N 189 
GLY   H    H N N 190 
GLY   H2   H N N 191 
GLY   HA2  H N N 192 
GLY   HA3  H N N 193 
GLY   HXT  H N N 194 
HIS   N    N N N 195 
HIS   CA   C N S 196 
HIS   C    C N N 197 
HIS   O    O N N 198 
HIS   CB   C N N 199 
HIS   CG   C Y N 200 
HIS   ND1  N Y N 201 
HIS   CD2  C Y N 202 
HIS   CE1  C Y N 203 
HIS   NE2  N Y N 204 
HIS   OXT  O N N 205 
HIS   H    H N N 206 
HIS   H2   H N N 207 
HIS   HA   H N N 208 
HIS   HB2  H N N 209 
HIS   HB3  H N N 210 
HIS   HD1  H N N 211 
HIS   HD2  H N N 212 
HIS   HE1  H N N 213 
HIS   HE2  H N N 214 
HIS   HXT  H N N 215 
ILE   N    N N N 216 
ILE   CA   C N S 217 
ILE   C    C N N 218 
ILE   O    O N N 219 
ILE   CB   C N S 220 
ILE   CG1  C N N 221 
ILE   CG2  C N N 222 
ILE   CD1  C N N 223 
ILE   OXT  O N N 224 
ILE   H    H N N 225 
ILE   H2   H N N 226 
ILE   HA   H N N 227 
ILE   HB   H N N 228 
ILE   HG12 H N N 229 
ILE   HG13 H N N 230 
ILE   HG21 H N N 231 
ILE   HG22 H N N 232 
ILE   HG23 H N N 233 
ILE   HD11 H N N 234 
ILE   HD12 H N N 235 
ILE   HD13 H N N 236 
ILE   HXT  H N N 237 
LEU   N    N N N 238 
LEU   CA   C N S 239 
LEU   C    C N N 240 
LEU   O    O N N 241 
LEU   CB   C N N 242 
LEU   CG   C N N 243 
LEU   CD1  C N N 244 
LEU   CD2  C N N 245 
LEU   OXT  O N N 246 
LEU   H    H N N 247 
LEU   H2   H N N 248 
LEU   HA   H N N 249 
LEU   HB2  H N N 250 
LEU   HB3  H N N 251 
LEU   HG   H N N 252 
LEU   HD11 H N N 253 
LEU   HD12 H N N 254 
LEU   HD13 H N N 255 
LEU   HD21 H N N 256 
LEU   HD22 H N N 257 
LEU   HD23 H N N 258 
LEU   HXT  H N N 259 
LYS   N    N N N 260 
LYS   CA   C N S 261 
LYS   C    C N N 262 
LYS   O    O N N 263 
LYS   CB   C N N 264 
LYS   CG   C N N 265 
LYS   CD   C N N 266 
LYS   CE   C N N 267 
LYS   NZ   N N N 268 
LYS   OXT  O N N 269 
LYS   H    H N N 270 
LYS   H2   H N N 271 
LYS   HA   H N N 272 
LYS   HB2  H N N 273 
LYS   HB3  H N N 274 
LYS   HG2  H N N 275 
LYS   HG3  H N N 276 
LYS   HD2  H N N 277 
LYS   HD3  H N N 278 
LYS   HE2  H N N 279 
LYS   HE3  H N N 280 
LYS   HZ1  H N N 281 
LYS   HZ2  H N N 282 
LYS   HZ3  H N N 283 
LYS   HXT  H N N 284 
MET   N    N N N 285 
MET   CA   C N S 286 
MET   C    C N N 287 
MET   O    O N N 288 
MET   CB   C N N 289 
MET   CG   C N N 290 
MET   SD   S N N 291 
MET   CE   C N N 292 
MET   OXT  O N N 293 
MET   H    H N N 294 
MET   H2   H N N 295 
MET   HA   H N N 296 
MET   HB2  H N N 297 
MET   HB3  H N N 298 
MET   HG2  H N N 299 
MET   HG3  H N N 300 
MET   HE1  H N N 301 
MET   HE2  H N N 302 
MET   HE3  H N N 303 
MET   HXT  H N N 304 
PHE   N    N N N 305 
PHE   CA   C N S 306 
PHE   C    C N N 307 
PHE   O    O N N 308 
PHE   CB   C N N 309 
PHE   CG   C Y N 310 
PHE   CD1  C Y N 311 
PHE   CD2  C Y N 312 
PHE   CE1  C Y N 313 
PHE   CE2  C Y N 314 
PHE   CZ   C Y N 315 
PHE   OXT  O N N 316 
PHE   H    H N N 317 
PHE   H2   H N N 318 
PHE   HA   H N N 319 
PHE   HB2  H N N 320 
PHE   HB3  H N N 321 
PHE   HD1  H N N 322 
PHE   HD2  H N N 323 
PHE   HE1  H N N 324 
PHE   HE2  H N N 325 
PHE   HZ   H N N 326 
PHE   HXT  H N N 327 
PRO   N    N N N 328 
PRO   CA   C N S 329 
PRO   C    C N N 330 
PRO   O    O N N 331 
PRO   CB   C N N 332 
PRO   CG   C N N 333 
PRO   CD   C N N 334 
PRO   OXT  O N N 335 
PRO   H    H N N 336 
PRO   HA   H N N 337 
PRO   HB2  H N N 338 
PRO   HB3  H N N 339 
PRO   HG2  H N N 340 
PRO   HG3  H N N 341 
PRO   HD2  H N N 342 
PRO   HD3  H N N 343 
PRO   HXT  H N N 344 
SER   N    N N N 345 
SER   CA   C N S 346 
SER   C    C N N 347 
SER   O    O N N 348 
SER   CB   C N N 349 
SER   OG   O N N 350 
SER   OXT  O N N 351 
SER   H    H N N 352 
SER   H2   H N N 353 
SER   HA   H N N 354 
SER   HB2  H N N 355 
SER   HB3  H N N 356 
SER   HG   H N N 357 
SER   HXT  H N N 358 
THR   N    N N N 359 
THR   CA   C N S 360 
THR   C    C N N 361 
THR   O    O N N 362 
THR   CB   C N R 363 
THR   OG1  O N N 364 
THR   CG2  C N N 365 
THR   OXT  O N N 366 
THR   H    H N N 367 
THR   H2   H N N 368 
THR   HA   H N N 369 
THR   HB   H N N 370 
THR   HG1  H N N 371 
THR   HG21 H N N 372 
THR   HG22 H N N 373 
THR   HG23 H N N 374 
THR   HXT  H N N 375 
TRP   N    N N N 376 
TRP   CA   C N S 377 
TRP   C    C N N 378 
TRP   O    O N N 379 
TRP   CB   C N N 380 
TRP   CG   C Y N 381 
TRP   CD1  C Y N 382 
TRP   CD2  C Y N 383 
TRP   NE1  N Y N 384 
TRP   CE2  C Y N 385 
TRP   CE3  C Y N 386 
TRP   CZ2  C Y N 387 
TRP   CZ3  C Y N 388 
TRP   CH2  C Y N 389 
TRP   OXT  O N N 390 
TRP   H    H N N 391 
TRP   H2   H N N 392 
TRP   HA   H N N 393 
TRP   HB2  H N N 394 
TRP   HB3  H N N 395 
TRP   HD1  H N N 396 
TRP   HE1  H N N 397 
TRP   HE3  H N N 398 
TRP   HZ2  H N N 399 
TRP   HZ3  H N N 400 
TRP   HH2  H N N 401 
TRP   HXT  H N N 402 
TYR   N    N N N 403 
TYR   CA   C N S 404 
TYR   C    C N N 405 
TYR   O    O N N 406 
TYR   CB   C N N 407 
TYR   CG   C Y N 408 
TYR   CD1  C Y N 409 
TYR   CD2  C Y N 410 
TYR   CE1  C Y N 411 
TYR   CE2  C Y N 412 
TYR   CZ   C Y N 413 
TYR   OH   O N N 414 
TYR   OXT  O N N 415 
TYR   H    H N N 416 
TYR   H2   H N N 417 
TYR   HA   H N N 418 
TYR   HB2  H N N 419 
TYR   HB3  H N N 420 
TYR   HD1  H N N 421 
TYR   HD2  H N N 422 
TYR   HE1  H N N 423 
TYR   HE2  H N N 424 
TYR   HH   H N N 425 
TYR   HXT  H N N 426 
VAL   N    N N N 427 
VAL   CA   C N S 428 
VAL   C    C N N 429 
VAL   O    O N N 430 
VAL   CB   C N N 431 
VAL   CG1  C N N 432 
VAL   CG2  C N N 433 
VAL   OXT  O N N 434 
VAL   H    H N N 435 
VAL   H2   H N N 436 
VAL   HA   H N N 437 
VAL   HB   H N N 438 
VAL   HG11 H N N 439 
VAL   HG12 H N N 440 
VAL   HG13 H N N 441 
VAL   HG21 H N N 442 
VAL   HG22 H N N 443 
VAL   HG23 H N N 444 
VAL   HXT  H N N 445 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LW2 I26 C25  sing N N 1   
A1LW2 C24 C25  doub Y N 2   
A1LW2 C24 C23  sing Y N 3   
A1LW2 C25 C20  sing Y N 4   
A1LW2 C23 C22  doub Y N 5   
A1LW2 C20 C17  sing N N 6   
A1LW2 C20 C21  doub Y N 7   
A1LW2 C22 C21  sing Y N 8   
A1LW2 C1  C2   sing N N 9   
A1LW2 C17 C16  doub Y N 10  
A1LW2 C17 C18  sing Y N 11  
A1LW2 C16 C15  sing Y N 12  
A1LW2 C4  C3   sing N N 13  
A1LW2 C4  C5   sing N N 14  
A1LW2 C18 C19  doub Y N 15  
A1LW2 C3  C2   sing N N 16  
A1LW2 C3  C8   sing N N 17  
A1LW2 C27 C2   sing N N 18  
A1LW2 C2  C7   sing N N 19  
A1LW2 C15 C14  doub Y N 20  
A1LW2 C19 C14  sing Y N 21  
A1LW2 C14 C13  sing N N 22  
A1LW2 C13 N10  sing N N 23  
A1LW2 C5  C6   doub N N 24  
A1LW2 C8  C7   sing N N 25  
A1LW2 C7  C6   sing N N 26  
A1LW2 C6  C9   sing N N 27  
A1LW2 N10 C11  sing N N 28  
A1LW2 N10 C9   sing N N 29  
A1LW2 N10 C12  sing N N 30  
A1LW2 C4  H1   sing N N 31  
A1LW2 C4  H2   sing N N 32  
A1LW2 C5  H3   sing N N 33  
A1LW2 C7  H6   sing N N 34  
A1LW2 C8  H7   sing N N 35  
A1LW2 C8  H8   sing N N 36  
A1LW2 C13 H9   sing N N 37  
A1LW2 C13 H10  sing N N 38  
A1LW2 C15 H11  sing N N 39  
A1LW2 C21 H12  sing N N 40  
A1LW2 C22 H13  sing N N 41  
A1LW2 C24 H14  sing N N 42  
A1LW2 C1  H15  sing N N 43  
A1LW2 C1  H16  sing N N 44  
A1LW2 C1  H17  sing N N 45  
A1LW2 C11 H18  sing N N 46  
A1LW2 C11 H19  sing N N 47  
A1LW2 C11 H20  sing N N 48  
A1LW2 C12 H21  sing N N 49  
A1LW2 C12 H22  sing N N 50  
A1LW2 C12 H23  sing N N 51  
A1LW2 C16 H24  sing N N 52  
A1LW2 C18 H25  sing N N 53  
A1LW2 C19 H26  sing N N 54  
A1LW2 C23 H27  sing N N 55  
A1LW2 C27 H28  sing N N 56  
A1LW2 C27 H29  sing N N 57  
A1LW2 C27 H30  sing N N 58  
A1LW2 C3  H31  sing N N 59  
A1LW2 C9  H32  sing N N 60  
A1LW2 C9  H33  sing N N 61  
ALA   N   CA   sing N N 62  
ALA   N   H    sing N N 63  
ALA   N   H2   sing N N 64  
ALA   CA  C    sing N N 65  
ALA   CA  CB   sing N N 66  
ALA   CA  HA   sing N N 67  
ALA   C   O    doub N N 68  
ALA   C   OXT  sing N N 69  
ALA   CB  HB1  sing N N 70  
ALA   CB  HB2  sing N N 71  
ALA   CB  HB3  sing N N 72  
ALA   OXT HXT  sing N N 73  
ARG   N   CA   sing N N 74  
ARG   N   H    sing N N 75  
ARG   N   H2   sing N N 76  
ARG   CA  C    sing N N 77  
ARG   CA  CB   sing N N 78  
ARG   CA  HA   sing N N 79  
ARG   C   O    doub N N 80  
ARG   C   OXT  sing N N 81  
ARG   CB  CG   sing N N 82  
ARG   CB  HB2  sing N N 83  
ARG   CB  HB3  sing N N 84  
ARG   CG  CD   sing N N 85  
ARG   CG  HG2  sing N N 86  
ARG   CG  HG3  sing N N 87  
ARG   CD  NE   sing N N 88  
ARG   CD  HD2  sing N N 89  
ARG   CD  HD3  sing N N 90  
ARG   NE  CZ   sing N N 91  
ARG   NE  HE   sing N N 92  
ARG   CZ  NH1  sing N N 93  
ARG   CZ  NH2  doub N N 94  
ARG   NH1 HH11 sing N N 95  
ARG   NH1 HH12 sing N N 96  
ARG   NH2 HH21 sing N N 97  
ARG   NH2 HH22 sing N N 98  
ARG   OXT HXT  sing N N 99  
ASN   N   CA   sing N N 100 
ASN   N   H    sing N N 101 
ASN   N   H2   sing N N 102 
ASN   CA  C    sing N N 103 
ASN   CA  CB   sing N N 104 
ASN   CA  HA   sing N N 105 
ASN   C   O    doub N N 106 
ASN   C   OXT  sing N N 107 
ASN   CB  CG   sing N N 108 
ASN   CB  HB2  sing N N 109 
ASN   CB  HB3  sing N N 110 
ASN   CG  OD1  doub N N 111 
ASN   CG  ND2  sing N N 112 
ASN   ND2 HD21 sing N N 113 
ASN   ND2 HD22 sing N N 114 
ASN   OXT HXT  sing N N 115 
ASP   N   CA   sing N N 116 
ASP   N   H    sing N N 117 
ASP   N   H2   sing N N 118 
ASP   CA  C    sing N N 119 
ASP   CA  CB   sing N N 120 
ASP   CA  HA   sing N N 121 
ASP   C   O    doub N N 122 
ASP   C   OXT  sing N N 123 
ASP   CB  CG   sing N N 124 
ASP   CB  HB2  sing N N 125 
ASP   CB  HB3  sing N N 126 
ASP   CG  OD1  doub N N 127 
ASP   CG  OD2  sing N N 128 
ASP   OD2 HD2  sing N N 129 
ASP   OXT HXT  sing N N 130 
CYS   N   CA   sing N N 131 
CYS   N   H    sing N N 132 
CYS   N   H2   sing N N 133 
CYS   CA  C    sing N N 134 
CYS   CA  CB   sing N N 135 
CYS   CA  HA   sing N N 136 
CYS   C   O    doub N N 137 
CYS   C   OXT  sing N N 138 
CYS   CB  SG   sing N N 139 
CYS   CB  HB2  sing N N 140 
CYS   CB  HB3  sing N N 141 
CYS   SG  HG   sing N N 142 
CYS   OXT HXT  sing N N 143 
GLN   N   CA   sing N N 144 
GLN   N   H    sing N N 145 
GLN   N   H2   sing N N 146 
GLN   CA  C    sing N N 147 
GLN   CA  CB   sing N N 148 
GLN   CA  HA   sing N N 149 
GLN   C   O    doub N N 150 
GLN   C   OXT  sing N N 151 
GLN   CB  CG   sing N N 152 
GLN   CB  HB2  sing N N 153 
GLN   CB  HB3  sing N N 154 
GLN   CG  CD   sing N N 155 
GLN   CG  HG2  sing N N 156 
GLN   CG  HG3  sing N N 157 
GLN   CD  OE1  doub N N 158 
GLN   CD  NE2  sing N N 159 
GLN   NE2 HE21 sing N N 160 
GLN   NE2 HE22 sing N N 161 
GLN   OXT HXT  sing N N 162 
GLU   N   CA   sing N N 163 
GLU   N   H    sing N N 164 
GLU   N   H2   sing N N 165 
GLU   CA  C    sing N N 166 
GLU   CA  CB   sing N N 167 
GLU   CA  HA   sing N N 168 
GLU   C   O    doub N N 169 
GLU   C   OXT  sing N N 170 
GLU   CB  CG   sing N N 171 
GLU   CB  HB2  sing N N 172 
GLU   CB  HB3  sing N N 173 
GLU   CG  CD   sing N N 174 
GLU   CG  HG2  sing N N 175 
GLU   CG  HG3  sing N N 176 
GLU   CD  OE1  doub N N 177 
GLU   CD  OE2  sing N N 178 
GLU   OE2 HE2  sing N N 179 
GLU   OXT HXT  sing N N 180 
GLY   N   CA   sing N N 181 
GLY   N   H    sing N N 182 
GLY   N   H2   sing N N 183 
GLY   CA  C    sing N N 184 
GLY   CA  HA2  sing N N 185 
GLY   CA  HA3  sing N N 186 
GLY   C   O    doub N N 187 
GLY   C   OXT  sing N N 188 
GLY   OXT HXT  sing N N 189 
HIS   N   CA   sing N N 190 
HIS   N   H    sing N N 191 
HIS   N   H2   sing N N 192 
HIS   CA  C    sing N N 193 
HIS   CA  CB   sing N N 194 
HIS   CA  HA   sing N N 195 
HIS   C   O    doub N N 196 
HIS   C   OXT  sing N N 197 
HIS   CB  CG   sing N N 198 
HIS   CB  HB2  sing N N 199 
HIS   CB  HB3  sing N N 200 
HIS   CG  ND1  sing Y N 201 
HIS   CG  CD2  doub Y N 202 
HIS   ND1 CE1  doub Y N 203 
HIS   ND1 HD1  sing N N 204 
HIS   CD2 NE2  sing Y N 205 
HIS   CD2 HD2  sing N N 206 
HIS   CE1 NE2  sing Y N 207 
HIS   CE1 HE1  sing N N 208 
HIS   NE2 HE2  sing N N 209 
HIS   OXT HXT  sing N N 210 
ILE   N   CA   sing N N 211 
ILE   N   H    sing N N 212 
ILE   N   H2   sing N N 213 
ILE   CA  C    sing N N 214 
ILE   CA  CB   sing N N 215 
ILE   CA  HA   sing N N 216 
ILE   C   O    doub N N 217 
ILE   C   OXT  sing N N 218 
ILE   CB  CG1  sing N N 219 
ILE   CB  CG2  sing N N 220 
ILE   CB  HB   sing N N 221 
ILE   CG1 CD1  sing N N 222 
ILE   CG1 HG12 sing N N 223 
ILE   CG1 HG13 sing N N 224 
ILE   CG2 HG21 sing N N 225 
ILE   CG2 HG22 sing N N 226 
ILE   CG2 HG23 sing N N 227 
ILE   CD1 HD11 sing N N 228 
ILE   CD1 HD12 sing N N 229 
ILE   CD1 HD13 sing N N 230 
ILE   OXT HXT  sing N N 231 
LEU   N   CA   sing N N 232 
LEU   N   H    sing N N 233 
LEU   N   H2   sing N N 234 
LEU   CA  C    sing N N 235 
LEU   CA  CB   sing N N 236 
LEU   CA  HA   sing N N 237 
LEU   C   O    doub N N 238 
LEU   C   OXT  sing N N 239 
LEU   CB  CG   sing N N 240 
LEU   CB  HB2  sing N N 241 
LEU   CB  HB3  sing N N 242 
LEU   CG  CD1  sing N N 243 
LEU   CG  CD2  sing N N 244 
LEU   CG  HG   sing N N 245 
LEU   CD1 HD11 sing N N 246 
LEU   CD1 HD12 sing N N 247 
LEU   CD1 HD13 sing N N 248 
LEU   CD2 HD21 sing N N 249 
LEU   CD2 HD22 sing N N 250 
LEU   CD2 HD23 sing N N 251 
LEU   OXT HXT  sing N N 252 
LYS   N   CA   sing N N 253 
LYS   N   H    sing N N 254 
LYS   N   H2   sing N N 255 
LYS   CA  C    sing N N 256 
LYS   CA  CB   sing N N 257 
LYS   CA  HA   sing N N 258 
LYS   C   O    doub N N 259 
LYS   C   OXT  sing N N 260 
LYS   CB  CG   sing N N 261 
LYS   CB  HB2  sing N N 262 
LYS   CB  HB3  sing N N 263 
LYS   CG  CD   sing N N 264 
LYS   CG  HG2  sing N N 265 
LYS   CG  HG3  sing N N 266 
LYS   CD  CE   sing N N 267 
LYS   CD  HD2  sing N N 268 
LYS   CD  HD3  sing N N 269 
LYS   CE  NZ   sing N N 270 
LYS   CE  HE2  sing N N 271 
LYS   CE  HE3  sing N N 272 
LYS   NZ  HZ1  sing N N 273 
LYS   NZ  HZ2  sing N N 274 
LYS   NZ  HZ3  sing N N 275 
LYS   OXT HXT  sing N N 276 
MET   N   CA   sing N N 277 
MET   N   H    sing N N 278 
MET   N   H2   sing N N 279 
MET   CA  C    sing N N 280 
MET   CA  CB   sing N N 281 
MET   CA  HA   sing N N 282 
MET   C   O    doub N N 283 
MET   C   OXT  sing N N 284 
MET   CB  CG   sing N N 285 
MET   CB  HB2  sing N N 286 
MET   CB  HB3  sing N N 287 
MET   CG  SD   sing N N 288 
MET   CG  HG2  sing N N 289 
MET   CG  HG3  sing N N 290 
MET   SD  CE   sing N N 291 
MET   CE  HE1  sing N N 292 
MET   CE  HE2  sing N N 293 
MET   CE  HE3  sing N N 294 
MET   OXT HXT  sing N N 295 
PHE   N   CA   sing N N 296 
PHE   N   H    sing N N 297 
PHE   N   H2   sing N N 298 
PHE   CA  C    sing N N 299 
PHE   CA  CB   sing N N 300 
PHE   CA  HA   sing N N 301 
PHE   C   O    doub N N 302 
PHE   C   OXT  sing N N 303 
PHE   CB  CG   sing N N 304 
PHE   CB  HB2  sing N N 305 
PHE   CB  HB3  sing N N 306 
PHE   CG  CD1  doub Y N 307 
PHE   CG  CD2  sing Y N 308 
PHE   CD1 CE1  sing Y N 309 
PHE   CD1 HD1  sing N N 310 
PHE   CD2 CE2  doub Y N 311 
PHE   CD2 HD2  sing N N 312 
PHE   CE1 CZ   doub Y N 313 
PHE   CE1 HE1  sing N N 314 
PHE   CE2 CZ   sing Y N 315 
PHE   CE2 HE2  sing N N 316 
PHE   CZ  HZ   sing N N 317 
PHE   OXT HXT  sing N N 318 
PRO   N   CA   sing N N 319 
PRO   N   CD   sing N N 320 
PRO   N   H    sing N N 321 
PRO   CA  C    sing N N 322 
PRO   CA  CB   sing N N 323 
PRO   CA  HA   sing N N 324 
PRO   C   O    doub N N 325 
PRO   C   OXT  sing N N 326 
PRO   CB  CG   sing N N 327 
PRO   CB  HB2  sing N N 328 
PRO   CB  HB3  sing N N 329 
PRO   CG  CD   sing N N 330 
PRO   CG  HG2  sing N N 331 
PRO   CG  HG3  sing N N 332 
PRO   CD  HD2  sing N N 333 
PRO   CD  HD3  sing N N 334 
PRO   OXT HXT  sing N N 335 
SER   N   CA   sing N N 336 
SER   N   H    sing N N 337 
SER   N   H2   sing N N 338 
SER   CA  C    sing N N 339 
SER   CA  CB   sing N N 340 
SER   CA  HA   sing N N 341 
SER   C   O    doub N N 342 
SER   C   OXT  sing N N 343 
SER   CB  OG   sing N N 344 
SER   CB  HB2  sing N N 345 
SER   CB  HB3  sing N N 346 
SER   OG  HG   sing N N 347 
SER   OXT HXT  sing N N 348 
THR   N   CA   sing N N 349 
THR   N   H    sing N N 350 
THR   N   H2   sing N N 351 
THR   CA  C    sing N N 352 
THR   CA  CB   sing N N 353 
THR   CA  HA   sing N N 354 
THR   C   O    doub N N 355 
THR   C   OXT  sing N N 356 
THR   CB  OG1  sing N N 357 
THR   CB  CG2  sing N N 358 
THR   CB  HB   sing N N 359 
THR   OG1 HG1  sing N N 360 
THR   CG2 HG21 sing N N 361 
THR   CG2 HG22 sing N N 362 
THR   CG2 HG23 sing N N 363 
THR   OXT HXT  sing N N 364 
TRP   N   CA   sing N N 365 
TRP   N   H    sing N N 366 
TRP   N   H2   sing N N 367 
TRP   CA  C    sing N N 368 
TRP   CA  CB   sing N N 369 
TRP   CA  HA   sing N N 370 
TRP   C   O    doub N N 371 
TRP   C   OXT  sing N N 372 
TRP   CB  CG   sing N N 373 
TRP   CB  HB2  sing N N 374 
TRP   CB  HB3  sing N N 375 
TRP   CG  CD1  doub Y N 376 
TRP   CG  CD2  sing Y N 377 
TRP   CD1 NE1  sing Y N 378 
TRP   CD1 HD1  sing N N 379 
TRP   CD2 CE2  doub Y N 380 
TRP   CD2 CE3  sing Y N 381 
TRP   NE1 CE2  sing Y N 382 
TRP   NE1 HE1  sing N N 383 
TRP   CE2 CZ2  sing Y N 384 
TRP   CE3 CZ3  doub Y N 385 
TRP   CE3 HE3  sing N N 386 
TRP   CZ2 CH2  doub Y N 387 
TRP   CZ2 HZ2  sing N N 388 
TRP   CZ3 CH2  sing Y N 389 
TRP   CZ3 HZ3  sing N N 390 
TRP   CH2 HH2  sing N N 391 
TRP   OXT HXT  sing N N 392 
TYR   N   CA   sing N N 393 
TYR   N   H    sing N N 394 
TYR   N   H2   sing N N 395 
TYR   CA  C    sing N N 396 
TYR   CA  CB   sing N N 397 
TYR   CA  HA   sing N N 398 
TYR   C   O    doub N N 399 
TYR   C   OXT  sing N N 400 
TYR   CB  CG   sing N N 401 
TYR   CB  HB2  sing N N 402 
TYR   CB  HB3  sing N N 403 
TYR   CG  CD1  doub Y N 404 
TYR   CG  CD2  sing Y N 405 
TYR   CD1 CE1  sing Y N 406 
TYR   CD1 HD1  sing N N 407 
TYR   CD2 CE2  doub Y N 408 
TYR   CD2 HD2  sing N N 409 
TYR   CE1 CZ   doub Y N 410 
TYR   CE1 HE1  sing N N 411 
TYR   CE2 CZ   sing Y N 412 
TYR   CE2 HE2  sing N N 413 
TYR   CZ  OH   sing N N 414 
TYR   OH  HH   sing N N 415 
TYR   OXT HXT  sing N N 416 
VAL   N   CA   sing N N 417 
VAL   N   H    sing N N 418 
VAL   N   H2   sing N N 419 
VAL   CA  C    sing N N 420 
VAL   CA  CB   sing N N 421 
VAL   CA  HA   sing N N 422 
VAL   C   O    doub N N 423 
VAL   C   OXT  sing N N 424 
VAL   CB  CG1  sing N N 425 
VAL   CB  CG2  sing N N 426 
VAL   CB  HB   sing N N 427 
VAL   CG1 HG11 sing N N 428 
VAL   CG1 HG12 sing N N 429 
VAL   CG1 HG13 sing N N 430 
VAL   CG2 HG21 sing N N 431 
VAL   CG2 HG22 sing N N 432 
VAL   CG2 HG23 sing N N 433 
VAL   OXT HXT  sing N N 434 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-01-22 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8Y0H 
_em_admin.last_update        2025-04-09 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50.1 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ?         ?   
'IMAGE ACQUISITION'        ? 2  ? ? 1 ?         ?   
MASKING                    ? 3  ? ? ? ?         ?   
'CTF CORRECTION'           ? 4  1 ? ? ?         ?   
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ?   
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ?   
'MODEL FITTING'            ? 7  ? 1 ? Coot      ?   
OTHER                      ? 8  ? ? ? ?         ?   
'INITIAL EULER ASSIGNMENT' ? 9  1 ? ? ?         ?   
'FINAL EULER ASSIGNMENT'   ? 10 1 ? ? ?         ?   
CLASSIFICATION             ? 11 1 ? ? cryoSPARC 4.4 
RECONSTRUCTION             ? 12 1 ? ? cryoSPARC 4.4 
'MODEL REFINEMENT'         ? 13 ? 1 ? PHENIX    ?   
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Science and Engineering Research Board (SERB)' 
_pdbx_audit_support.country                India 
_pdbx_audit_support.grant_number           IPA/2020/000405 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
# 
_atom_sites.entry_id                    8Y0H 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
I 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO   A 1 113 ? 143.804 120.548 157.920 1.00 94.38  ? 57  PRO   R N   1 
ATOM   2    C CA  . PRO   A 1 113 ? 144.000 121.378 156.730 1.00 94.38  ? 57  PRO   R CA  1 
ATOM   3    C C   . PRO   A 1 113 ? 144.254 120.558 155.469 1.00 94.38  ? 57  PRO   R C   1 
ATOM   4    O O   . PRO   A 1 113 ? 143.963 121.020 154.368 1.00 94.38  ? 57  PRO   R O   1 
ATOM   5    C CB  . PRO   A 1 113 ? 145.226 122.213 157.094 1.00 94.38  ? 57  PRO   R CB  1 
ATOM   6    C CG  . PRO   A 1 113 ? 146.013 121.343 158.025 1.00 94.38  ? 57  PRO   R CG  1 
ATOM   7    C CD  . PRO   A 1 113 ? 145.058 120.368 158.673 1.00 94.38  ? 57  PRO   R CD  1 
ATOM   8    N N   . ALA   A 1 114 ? 144.795 119.349 155.635 1.00 94.14  ? 58  ALA   R N   1 
ATOM   9    C CA  . ALA   A 1 114 ? 145.040 118.493 154.480 1.00 94.14  ? 58  ALA   R CA  1 
ATOM   10   C C   . ALA   A 1 114 ? 143.738 118.140 153.774 1.00 94.14  ? 58  ALA   R C   1 
ATOM   11   O O   . ALA   A 1 114 ? 143.666 118.160 152.540 1.00 94.14  ? 58  ALA   R O   1 
ATOM   12   C CB  . ALA   A 1 114 ? 145.777 117.226 154.913 1.00 94.14  ? 58  ALA   R CB  1 
ATOM   13   N N   . LEU   A 1 115 ? 142.695 117.814 154.542 1.00 94.92  ? 59  LEU   R N   1 
ATOM   14   C CA  . LEU   A 1 115 ? 141.401 117.523 153.936 1.00 94.92  ? 59  LEU   R CA  1 
ATOM   15   C C   . LEU   A 1 115 ? 140.823 118.760 153.260 1.00 94.92  ? 59  LEU   R C   1 
ATOM   16   O O   . LEU   A 1 115 ? 140.190 118.660 152.202 1.00 94.92  ? 59  LEU   R O   1 
ATOM   17   C CB  . LEU   A 1 115 ? 140.437 116.978 154.991 1.00 94.92  ? 59  LEU   R CB  1 
ATOM   18   C CG  . LEU   A 1 115 ? 139.955 117.960 156.059 1.00 94.92  ? 59  LEU   R CG  1 
ATOM   19   C CD1 . LEU   A 1 115 ? 138.575 118.498 155.714 1.00 94.92  ? 59  LEU   R CD1 1 
ATOM   20   C CD2 . LEU   A 1 115 ? 139.946 117.294 157.427 1.00 94.92  ? 59  LEU   R CD2 1 
ATOM   21   N N   . TYR   A 1 116 ? 141.027 119.937 153.856 1.00 94.64  ? 60  TYR   R N   1 
ATOM   22   C CA  . TYR   A 1 116 ? 140.608 121.172 153.203 1.00 94.64  ? 60  TYR   R CA  1 
ATOM   23   C C   . TYR   A 1 116 ? 141.266 121.309 151.836 1.00 94.64  ? 60  TYR   R C   1 
ATOM   24   O O   . TYR   A 1 116 ? 140.592 121.557 150.830 1.00 94.64  ? 60  TYR   R O   1 
ATOM   25   C CB  . TYR   A 1 116 ? 140.952 122.380 154.079 1.00 94.64  ? 60  TYR   R CB  1 
ATOM   26   C CG  . TYR   A 1 116 ? 140.143 122.498 155.354 1.00 94.64  ? 60  TYR   R CG  1 
ATOM   27   C CD1 . TYR   A 1 116 ? 140.314 121.599 156.399 1.00 94.64  ? 60  TYR   R CD1 1 
ATOM   28   C CD2 . TYR   A 1 116 ? 139.214 123.518 155.516 1.00 94.64  ? 60  TYR   R CD2 1 
ATOM   29   C CE1 . TYR   A 1 116 ? 139.579 121.710 157.567 1.00 94.64  ? 60  TYR   R CE1 1 
ATOM   30   C CE2 . TYR   A 1 116 ? 138.475 123.636 156.679 1.00 94.64  ? 60  TYR   R CE2 1 
ATOM   31   C CZ  . TYR   A 1 116 ? 138.661 122.731 157.700 1.00 94.64  ? 60  TYR   R CZ  1 
ATOM   32   O OH  . TYR   A 1 116 ? 137.927 122.845 158.859 1.00 94.64  ? 60  TYR   R OH  1 
ATOM   33   N N   . SER   A 1 117 ? 142.589 121.143 151.782 1.00 95.24  ? 61  SER   R N   1 
ATOM   34   C CA  . SER   A 1 117 ? 143.299 121.274 150.514 1.00 95.24  ? 61  SER   R CA  1 
ATOM   35   C C   . SER   A 1 117 ? 142.862 120.204 149.523 1.00 95.24  ? 61  SER   R C   1 
ATOM   36   O O   . SER   A 1 117 ? 142.689 120.484 148.331 1.00 95.24  ? 61  SER   R O   1 
ATOM   37   C CB  . SER   A 1 117 ? 144.808 121.202 150.747 1.00 95.24  ? 61  SER   R CB  1 
ATOM   38   O OG  . SER   A 1 117 ? 145.515 121.302 149.523 1.00 95.24  ? 61  SER   R OG  1 
ATOM   39   N N   . LEU   A 1 118 ? 142.681 118.968 149.993 1.00 92.28  ? 62  LEU   R N   1 
ATOM   40   C CA  . LEU   A 1 118 ? 142.224 117.906 149.103 1.00 92.28  ? 62  LEU   R CA  1 
ATOM   41   C C   . LEU   A 1 118 ? 140.852 118.239 148.533 1.00 92.28  ? 62  LEU   R C   1 
ATOM   42   O O   . LEU   A 1 118 ? 140.588 118.019 147.346 1.00 92.28  ? 62  LEU   R O   1 
ATOM   43   C CB  . LEU   A 1 118 ? 142.196 116.572 149.848 1.00 92.28  ? 62  LEU   R CB  1 
ATOM   44   C CG  . LEU   A 1 118 ? 141.559 115.396 149.104 1.00 92.28  ? 62  LEU   R CG  1 
ATOM   45   C CD1 . LEU   A 1 118 ? 142.261 115.151 147.779 1.00 92.28  ? 62  LEU   R CD1 1 
ATOM   46   C CD2 . LEU   A 1 118 ? 141.598 114.145 149.966 1.00 92.28  ? 62  LEU   R CD2 1 
ATOM   47   N N   . LEU   A 1 119 ? 139.964 118.780 149.369 1.00 89.52  ? 63  LEU   R N   1 
ATOM   48   C CA  . LEU   A 1 119 ? 138.667 119.236 148.884 1.00 89.52  ? 63  LEU   R CA  1 
ATOM   49   C C   . LEU   A 1 119 ? 138.845 120.290 147.799 1.00 89.52  ? 63  LEU   R C   1 
ATOM   50   O O   . LEU   A 1 119 ? 138.152 120.278 146.776 1.00 89.52  ? 63  LEU   R O   1 
ATOM   51   C CB  . LEU   A 1 119 ? 137.842 119.790 150.049 1.00 89.52  ? 63  LEU   R CB  1 
ATOM   52   C CG  . LEU   A 1 119 ? 136.711 118.905 150.581 1.00 89.52  ? 63  LEU   R CG  1 
ATOM   53   C CD1 . LEU   A 1 119 ? 136.087 119.520 151.822 1.00 89.52  ? 63  LEU   R CD1 1 
ATOM   54   C CD2 . LEU   A 1 119 ? 135.652 118.681 149.519 1.00 89.52  ? 63  LEU   R CD2 1 
ATOM   55   N N   . PHE   A 1 120 ? 139.782 121.213 148.011 1.00 90.29  ? 64  PHE   R N   1 
ATOM   56   C CA  . PHE   A 1 120 ? 140.052 122.282 147.056 1.00 90.29  ? 64  PHE   R CA  1 
ATOM   57   C C   . PHE   A 1 120 ? 140.479 121.726 145.704 1.00 90.29  ? 64  PHE   R C   1 
ATOM   58   O O   . PHE   A 1 120 ? 139.929 122.111 144.668 1.00 90.29  ? 64  PHE   R O   1 
ATOM   59   C CB  . PHE   A 1 120 ? 141.132 123.216 147.606 1.00 90.29  ? 64  PHE   R CB  1 
ATOM   60   C CG  . PHE   A 1 120 ? 141.319 124.467 146.800 1.00 90.29  ? 64  PHE   R CG  1 
ATOM   61   C CD1 . PHE   A 1 120 ? 140.328 125.430 146.752 1.00 90.29  ? 64  PHE   R CD1 1 
ATOM   62   C CD2 . PHE   A 1 120 ? 142.492 124.685 146.098 1.00 90.29  ? 64  PHE   R CD2 1 
ATOM   63   C CE1 . PHE   A 1 120 ? 140.499 126.586 146.014 1.00 90.29  ? 64  PHE   R CE1 1 
ATOM   64   C CE2 . PHE   A 1 120 ? 142.668 125.838 145.358 1.00 90.29  ? 64  PHE   R CE2 1 
ATOM   65   C CZ  . PHE   A 1 120 ? 141.670 126.790 145.317 1.00 90.29  ? 64  PHE   R CZ  1 
ATOM   66   N N   . LEU   A 1 121 ? 141.455 120.817 145.702 1.00 91.20  ? 65  LEU   R N   1 
ATOM   67   C CA  . LEU   A 1 121 ? 141.988 120.305 144.445 1.00 91.20  ? 65  LEU   R CA  1 
ATOM   68   C C   . LEU   A 1 121 ? 140.911 119.587 143.639 1.00 91.20  ? 65  LEU   R C   1 
ATOM   69   O O   . LEU   A 1 121 ? 140.743 119.834 142.440 1.00 91.20  ? 65  LEU   R O   1 
ATOM   70   C CB  . LEU   A 1 121 ? 143.172 119.376 144.723 1.00 91.20  ? 65  LEU   R CB  1 
ATOM   71   C CG  . LEU   A 1 121 ? 144.359 120.042 145.422 1.00 91.20  ? 65  LEU   R CG  1 
ATOM   72   C CD1 . LEU   A 1 121 ? 145.012 119.089 146.410 1.00 91.20  ? 65  LEU   R CD1 1 
ATOM   73   C CD2 . LEU   A 1 121 ? 145.373 120.544 144.407 1.00 91.20  ? 65  LEU   R CD2 1 
ATOM   74   N N   . LEU   A 1 122 ? 140.160 118.695 144.288 1.00 90.53  ? 66  LEU   R N   1 
ATOM   75   C CA  . LEU   A 1 122 ? 139.119 117.956 143.582 1.00 90.53  ? 66  LEU   R CA  1 
ATOM   76   C C   . LEU   A 1 122 ? 138.064 118.904 143.024 1.00 90.53  ? 66  LEU   R C   1 
ATOM   77   O O   . LEU   A 1 122 ? 137.626 118.766 141.877 1.00 90.53  ? 66  LEU   R O   1 
ATOM   78   C CB  . LEU   A 1 122 ? 138.480 116.923 144.515 1.00 90.53  ? 66  LEU   R CB  1 
ATOM   79   C CG  . LEU   A 1 122 ? 139.404 115.881 145.155 1.00 90.53  ? 66  LEU   R CG  1 
ATOM   80   C CD1 . LEU   A 1 122 ? 138.620 114.626 145.515 1.00 90.53  ? 66  LEU   R CD1 1 
ATOM   81   C CD2 . LEU   A 1 122 ? 140.578 115.534 144.249 1.00 90.53  ? 66  LEU   R CD2 1 
ATOM   82   N N   . GLY   A 1 123 ? 137.650 119.880 143.826 1.00 87.09  ? 67  GLY   R N   1 
ATOM   83   C CA  . GLY   A 1 123 ? 136.643 120.826 143.390 1.00 87.09  ? 67  GLY   R CA  1 
ATOM   84   C C   . GLY   A 1 123 ? 137.066 121.595 142.156 1.00 87.09  ? 67  GLY   R C   1 
ATOM   85   O O   . GLY   A 1 123 ? 136.298 121.713 141.197 1.00 87.09  ? 67  GLY   R O   1 
ATOM   86   N N   . LEU   A 1 124 ? 138.291 122.122 142.166 1.00 86.16  ? 68  LEU   R N   1 
ATOM   87   C CA  . LEU   A 1 124 ? 138.807 122.845 141.011 1.00 86.16  ? 68  LEU   R CA  1 
ATOM   88   C C   . LEU   A 1 124 ? 138.910 121.934 139.793 1.00 86.16  ? 68  LEU   R C   1 
ATOM   89   O O   . LEU   A 1 124 ? 138.508 122.303 138.684 1.00 86.16  ? 68  LEU   R O   1 
ATOM   90   C CB  . LEU   A 1 124 ? 140.174 123.453 141.348 1.00 86.16  ? 68  LEU   R CB  1 
ATOM   91   C CG  . LEU   A 1 124 ? 140.183 124.863 141.948 1.00 86.16  ? 68  LEU   R CG  1 
ATOM   92   C CD1 . LEU   A 1 124 ? 139.646 125.879 140.953 1.00 86.16  ? 68  LEU   R CD1 1 
ATOM   93   C CD2 . LEU   A 1 124 ? 139.389 124.916 143.246 1.00 86.16  ? 68  LEU   R CD2 1 
ATOM   94   N N   . LEU   A 1 125 ? 139.448 120.731 139.991 1.00 86.61  ? 69  LEU   R N   1 
ATOM   95   C CA  . LEU   A 1 125 ? 139.629 119.785 138.899 1.00 86.61  ? 69  LEU   R CA  1 
ATOM   96   C C   . LEU   A 1 125 ? 138.289 119.326 138.337 1.00 86.61  ? 69  LEU   R C   1 
ATOM   97   O O   . LEU   A 1 125 ? 138.104 119.283 137.117 1.00 86.61  ? 69  LEU   R O   1 
ATOM   98   C CB  . LEU   A 1 125 ? 140.445 118.578 139.370 1.00 86.61  ? 69  LEU   R CB  1 
ATOM   99   C CG  . LEU   A 1 125 ? 141.961 118.680 139.180 1.00 86.61  ? 69  LEU   R CG  1 
ATOM   100  C CD1 . LEU   A 1 125 ? 142.579 119.656 140.169 1.00 86.61  ? 69  LEU   R CD1 1 
ATOM   101  C CD2 . LEU   A 1 125 ? 142.604 117.307 139.310 1.00 86.61  ? 69  LEU   R CD2 1 
ATOM   102  N N   . GLY   A 1 126 ? 137.350 118.976 139.217 1.00 81.29  ? 70  GLY   R N   1 
ATOM   103  C CA  . GLY   A 1 126 ? 136.071 118.467 138.748 1.00 81.29  ? 70  GLY   R CA  1 
ATOM   104  C C   . GLY   A 1 126 ? 135.282 119.495 137.965 1.00 81.29  ? 70  GLY   R C   1 
ATOM   105  O O   . GLY   A 1 126 ? 134.893 119.261 136.819 1.00 81.29  ? 70  GLY   R O   1 
ATOM   106  N N   . ASN   A 1 127 ? 135.036 120.657 138.573 1.00 76.87  ? 71  ASN   R N   1 
ATOM   107  C CA  . ASN   A 1 127 ? 134.250 121.684 137.898 1.00 76.87  ? 71  ASN   R CA  1 
ATOM   108  C C   . ASN   A 1 127 ? 134.970 122.207 136.664 1.00 76.87  ? 71  ASN   R C   1 
ATOM   109  O O   . ASN   A 1 127 ? 134.345 122.442 135.623 1.00 76.87  ? 71  ASN   R O   1 
ATOM   110  C CB  . ASN   A 1 127 ? 133.940 122.825 138.864 1.00 76.87  ? 71  ASN   R CB  1 
ATOM   111  C CG  . ASN   A 1 127 ? 132.938 122.428 139.927 1.00 76.87  ? 71  ASN   R CG  1 
ATOM   112  O OD1 . ASN   A 1 127 ? 131.773 122.817 139.875 1.00 76.87  ? 71  ASN   R OD1 1 
ATOM   113  N ND2 . ASN   A 1 127 ? 133.390 121.653 140.903 1.00 76.87  ? 71  ASN   R ND2 1 
ATOM   114  N N   . GLY   A 1 128 ? 136.286 122.400 136.758 1.00 78.08  ? 72  GLY   R N   1 
ATOM   115  C CA  . GLY   A 1 128 ? 137.030 122.882 135.606 1.00 78.08  ? 72  GLY   R CA  1 
ATOM   116  C C   . GLY   A 1 128 ? 136.890 121.971 134.403 1.00 78.08  ? 72  GLY   R C   1 
ATOM   117  O O   . GLY   A 1 128 ? 136.734 122.438 133.272 1.00 78.08  ? 72  GLY   R O   1 
ATOM   118  N N   . ALA   A 1 129 ? 136.943 120.657 134.627 1.00 76.35  ? 73  ALA   R N   1 
ATOM   119  C CA  . ALA   A 1 129 ? 136.757 119.715 133.530 1.00 76.35  ? 73  ALA   R CA  1 
ATOM   120  C C   . ALA   A 1 129 ? 135.361 119.844 132.934 1.00 76.35  ? 73  ALA   R C   1 
ATOM   121  O O   . ALA   A 1 129 ? 135.194 119.864 131.709 1.00 76.35  ? 73  ALA   R O   1 
ATOM   122  C CB  . ALA   A 1 129 ? 137.005 118.288 134.019 1.00 76.35  ? 73  ALA   R CB  1 
ATOM   123  N N   . VAL   A 1 130 ? 134.342 119.943 133.791 1.00 72.26  ? 74  VAL   R N   1 
ATOM   124  C CA  . VAL   A 1 130 ? 132.969 120.037 133.303 1.00 72.26  ? 74  VAL   R CA  1 
ATOM   125  C C   . VAL   A 1 130 ? 132.801 121.280 132.441 1.00 72.26  ? 74  VAL   R C   1 
ATOM   126  O O   . VAL   A 1 130 ? 132.232 121.227 131.346 1.00 72.26  ? 74  VAL   R O   1 
ATOM   127  C CB  . VAL   A 1 130 ? 131.981 120.032 134.482 1.00 72.26  ? 74  VAL   R CB  1 
ATOM   128  C CG1 . VAL   A 1 130 ? 130.594 120.438 134.015 1.00 72.26  ? 74  VAL   R CG1 1 
ATOM   129  C CG2 . VAL   A 1 130 ? 131.948 118.662 135.136 1.00 72.26  ? 74  VAL   R CG2 1 
ATOM   130  N N   . ALA   A 1 131 ? 133.298 122.421 132.922 1.00 72.27  ? 75  ALA   R N   1 
ATOM   131  C CA  . ALA   A 1 131 ? 133.233 123.638 132.122 1.00 72.27  ? 75  ALA   R CA  1 
ATOM   132  C C   . ALA   A 1 131 ? 134.048 123.494 130.845 1.00 72.27  ? 75  ALA   R C   1 
ATOM   133  O O   . ALA   A 1 131 ? 133.633 123.960 129.778 1.00 72.27  ? 75  ALA   R O   1 
ATOM   134  C CB  . ALA   A 1 131 ? 133.722 124.832 132.939 1.00 72.27  ? 75  ALA   R CB  1 
ATOM   135  N N   . ALA   A 1 132 ? 135.215 122.854 130.935 1.00 74.81  ? 76  ALA   R N   1 
ATOM   136  C CA  . ALA   A 1 132 ? 136.055 122.679 129.755 1.00 74.81  ? 76  ALA   R CA  1 
ATOM   137  C C   . ALA   A 1 132 ? 135.345 121.841 128.699 1.00 74.81  ? 76  ALA   R C   1 
ATOM   138  O O   . ALA   A 1 132 ? 135.356 122.179 127.510 1.00 74.81  ? 76  ALA   R O   1 
ATOM   139  C CB  . ALA   A 1 132 ? 137.382 122.033 130.150 1.00 74.81  ? 76  ALA   R CB  1 
ATOM   140  N N   . VAL   A 1 133 ? 134.716 120.742 129.118 1.00 76.22  ? 77  VAL   R N   1 
ATOM   141  C CA  . VAL   A 1 133 ? 134.064 119.855 128.160 1.00 76.22  ? 77  VAL   R CA  1 
ATOM   142  C C   . VAL   A 1 133 ? 132.914 120.572 127.466 1.00 76.22  ? 77  VAL   R C   1 
ATOM   143  O O   . VAL   A 1 133 ? 132.766 120.497 126.241 1.00 76.22  ? 77  VAL   R O   1 
ATOM   144  C CB  . VAL   A 1 133 ? 133.585 118.573 128.863 1.00 76.22  ? 77  VAL   R CB  1 
ATOM   145  C CG1 . VAL   A 1 133 ? 132.640 117.800 127.964 1.00 76.22  ? 77  VAL   R CG1 1 
ATOM   146  C CG2 . VAL   A 1 133 ? 134.772 117.713 129.260 1.00 76.22  ? 77  VAL   R CG2 1 
ATOM   147  N N   . LEU   A 1 134 ? 132.085 121.280 128.233 1.00 71.01  ? 78  LEU   R N   1 
ATOM   148  C CA  . LEU   A 1 134 ? 130.920 121.930 127.644 1.00 71.01  ? 78  LEU   R CA  1 
ATOM   149  C C   . LEU   A 1 134 ? 131.318 123.087 126.738 1.00 71.01  ? 78  LEU   R C   1 
ATOM   150  O O   . LEU   A 1 134 ? 130.570 123.434 125.818 1.00 71.01  ? 78  LEU   R O   1 
ATOM   151  C CB  . LEU   A 1 134 ? 129.980 122.413 128.748 1.00 71.01  ? 78  LEU   R CB  1 
ATOM   152  C CG  . LEU   A 1 134 ? 129.390 121.308 129.630 1.00 71.01  ? 78  LEU   R CG  1 
ATOM   153  C CD1 . LEU   A 1 134 ? 128.714 121.897 130.854 1.00 71.01  ? 78  LEU   R CD1 1 
ATOM   154  C CD2 . LEU   A 1 134 ? 128.414 120.451 128.844 1.00 71.01  ? 78  LEU   R CD2 1 
ATOM   155  N N   . LEU   A 1 135 ? 132.481 123.695 126.977 1.00 72.53  ? 79  LEU   R N   1 
ATOM   156  C CA  . LEU   A 1 135 ? 132.959 124.787 126.139 1.00 72.53  ? 79  LEU   R CA  1 
ATOM   157  C C   . LEU   A 1 135 ? 133.721 124.305 124.913 1.00 72.53  ? 79  LEU   R C   1 
ATOM   158  O O   . LEU   A 1 135 ? 134.162 125.136 124.111 1.00 72.53  ? 79  LEU   R O   1 
ATOM   159  C CB  . LEU   A 1 135 ? 133.857 125.727 126.949 1.00 72.53  ? 79  LEU   R CB  1 
ATOM   160  C CG  . LEU   A 1 135 ? 133.149 126.639 127.953 1.00 72.53  ? 79  LEU   R CG  1 
ATOM   161  C CD1 . LEU   A 1 135 ? 134.166 127.470 128.716 1.00 72.53  ? 79  LEU   R CD1 1 
ATOM   162  C CD2 . LEU   A 1 135 ? 132.133 127.537 127.263 1.00 72.53  ? 79  LEU   R CD2 1 
ATOM   163  N N   . SER   A 1 136 ? 133.896 122.995 124.755 1.00 78.59  ? 80  SER   R N   1 
ATOM   164  C CA  . SER   A 1 136 ? 134.529 122.438 123.567 1.00 78.59  ? 80  SER   R CA  1 
ATOM   165  C C   . SER   A 1 136 ? 133.521 122.004 122.512 1.00 78.59  ? 80  SER   R C   1 
ATOM   166  O O   . SER   A 1 136 ? 133.893 121.271 121.589 1.00 78.59  ? 80  SER   R O   1 
ATOM   167  C CB  . SER   A 1 136 ? 135.411 121.251 123.953 1.00 78.59  ? 80  SER   R CB  1 
ATOM   168  O OG  . SER   A 1 136 ? 136.393 121.640 124.895 1.00 78.59  ? 80  SER   R OG  1 
ATOM   169  N N   . ARG   A 1 137 ? 132.265 122.427 122.627 1.00 84.22  ? 81  ARG   R N   1 
ATOM   170  C CA  . ARG   A 1 137 ? 131.245 122.079 121.646 1.00 84.22  ? 81  ARG   R CA  1 
ATOM   171  C C   . ARG   A 1 137 ? 131.151 123.155 120.573 1.00 84.22  ? 81  ARG   R C   1 
ATOM   172  O O   . ARG   A 1 137 ? 131.081 124.350 120.880 1.00 84.22  ? 81  ARG   R O   1 
ATOM   173  C CB  . ARG   A 1 137 ? 129.893 121.895 122.332 1.00 84.22  ? 81  ARG   R CB  1 
ATOM   174  C CG  . ARG   A 1 137 ? 129.777 120.598 123.107 1.00 84.22  ? 81  ARG   R CG  1 
ATOM   175  C CD  . ARG   A 1 137 ? 129.656 119.407 122.170 1.00 84.22  ? 81  ARG   R CD  1 
ATOM   176  N NE  . ARG   A 1 137 ? 128.379 119.405 121.462 1.00 84.22  ? 81  ARG   R NE  1 
ATOM   177  C CZ  . ARG   A 1 137 ? 128.229 119.540 120.150 1.00 84.22  ? 81  ARG   R CZ  1 
ATOM   178  N NH1 . ARG   A 1 137 ? 129.264 119.708 119.343 1.00 84.22  ? 81  ARG   R NH1 1 
ATOM   179  N NH2 . ARG   A 1 137 ? 127.004 119.508 119.633 1.00 84.22  ? 81  ARG   R NH2 1 
ATOM   180  N N   . ARG   A 1 138 ? 131.141 122.727 119.314 1.00 93.79  ? 82  ARG   R N   1 
ATOM   181  C CA  . ARG   A 1 138 ? 131.117 123.633 118.175 1.00 93.79  ? 82  ARG   R CA  1 
ATOM   182  C C   . ARG   A 1 138 ? 129.704 124.023 117.757 1.00 93.79  ? 82  ARG   R C   1 
ATOM   183  O O   . ARG   A 1 138 ? 129.546 124.781 116.795 1.00 93.79  ? 82  ARG   R O   1 
ATOM   184  C CB  . ARG   A 1 138 ? 131.845 123.007 116.978 1.00 93.79  ? 82  ARG   R CB  1 
ATOM   185  C CG  . ARG   A 1 138 ? 132.972 122.036 117.325 1.00 93.79  ? 82  ARG   R CG  1 
ATOM   186  C CD  . ARG   A 1 138 ? 133.530 121.378 116.071 1.00 93.79  ? 82  ARG   R CD  1 
ATOM   187  N NE  . ARG   A 1 138 ? 134.567 120.396 116.372 1.00 93.79  ? 82  ARG   R NE  1 
ATOM   188  C CZ  . ARG   A 1 138 ? 135.849 120.516 116.051 1.00 93.79  ? 82  ARG   R CZ  1 
ATOM   189  N NH1 . ARG   A 1 138 ? 136.319 121.597 115.448 1.00 93.79  ? 82  ARG   R NH1 1 
ATOM   190  N NH2 . ARG   A 1 138 ? 136.687 119.526 116.348 1.00 93.79  ? 82  ARG   R NH2 1 
ATOM   191  N N   . THR   A 1 139 ? 128.680 123.532 118.451 1.00 89.39  ? 83  THR   R N   1 
ATOM   192  C CA  . THR   A 1 139 ? 127.296 123.752 118.049 1.00 89.39  ? 83  THR   R CA  1 
ATOM   193  C C   . THR   A 1 139 ? 126.487 124.127 119.287 1.00 89.39  ? 83  THR   R C   1 
ATOM   194  O O   . THR   A 1 139 ? 127.038 124.391 120.360 1.00 89.39  ? 83  THR   R O   1 
ATOM   195  C CB  . THR   A 1 139 ? 126.728 122.510 117.347 1.00 89.39  ? 83  THR   R CB  1 
ATOM   196  O OG1 . THR   A 1 139 ? 126.287 121.561 118.325 1.00 89.39  ? 83  THR   R OG1 1 
ATOM   197  C CG2 . THR   A 1 139 ? 127.783 121.866 116.455 1.00 89.39  ? 83  THR   R CG2 1 
ATOM   198  N N   . ALA   A 1 140 ? 125.165 124.151 119.131 1.00 83.87  ? 84  ALA   R N   1 
ATOM   199  C CA  . ALA   A 1 140 ? 124.290 124.574 120.214 1.00 83.87  ? 84  ALA   R CA  1 
ATOM   200  C C   . ALA   A 1 140 ? 124.366 123.597 121.381 1.00 83.87  ? 84  ALA   R C   1 
ATOM   201  O O   . ALA   A 1 140 ? 124.669 122.413 121.214 1.00 83.87  ? 84  ALA   R O   1 
ATOM   202  C CB  . ALA   A 1 140 ? 122.849 124.686 119.719 1.00 83.87  ? 84  ALA   R CB  1 
ATOM   203  N N   . LEU   A 1 141 ? 124.084 124.110 122.575 1.00 71.80  ? 85  LEU   R N   1 
ATOM   204  C CA  . LEU   A 1 141 ? 124.112 123.331 123.804 1.00 71.80  ? 85  LEU   R CA  1 
ATOM   205  C C   . LEU   A 1 141 ? 122.703 123.228 124.365 1.00 71.80  ? 85  LEU   R C   1 
ATOM   206  O O   . LEU   A 1 141 ? 121.986 124.229 124.451 1.00 71.80  ? 85  LEU   R O   1 
ATOM   207  C CB  . LEU   A 1 141 ? 125.037 123.975 124.844 1.00 71.80  ? 85  LEU   R CB  1 
ATOM   208  C CG  . LEU   A 1 141 ? 126.438 123.394 125.048 1.00 71.80  ? 85  LEU   R CG  1 
ATOM   209  C CD1 . LEU   A 1 141 ? 127.024 123.922 126.347 1.00 71.80  ? 85  LEU   R CD1 1 
ATOM   210  C CD2 . LEU   A 1 141 ? 126.438 121.872 125.043 1.00 71.80  ? 85  LEU   R CD2 1 
ATOM   211  N N   . SER   A 1 142 ? 122.310 122.015 124.749 1.00 66.45  ? 86  SER   R N   1 
ATOM   212  C CA  . SER   A 1 142 ? 120.977 121.791 125.295 1.00 66.45  ? 86  SER   R CA  1 
ATOM   213  C C   . SER   A 1 142 ? 120.744 122.691 126.500 1.00 66.45  ? 86  SER   R C   1 
ATOM   214  O O   . SER   A 1 142 ? 121.700 123.192 127.100 1.00 66.45  ? 86  SER   R O   1 
ATOM   215  C CB  . SER   A 1 142 ? 120.793 120.325 125.685 1.00 66.45  ? 86  SER   R CB  1 
ATOM   216  O OG  . SER   A 1 142 ? 119.565 120.136 126.367 1.00 66.45  ? 86  SER   R OG  1 
ATOM   217  N N   . SER   A 1 143 ? 119.477 122.903 126.864 1.00 63.67  ? 87  SER   R N   1 
ATOM   218  C CA  . SER   A 1 143 ? 119.170 123.784 127.986 1.00 63.67  ? 87  SER   R CA  1 
ATOM   219  C C   . SER   A 1 143 ? 119.862 123.308 129.257 1.00 63.67  ? 87  SER   R C   1 
ATOM   220  O O   . SER   A 1 143 ? 120.535 124.087 129.946 1.00 63.67  ? 87  SER   R O   1 
ATOM   221  C CB  . SER   A 1 143 ? 117.658 123.851 128.192 1.00 63.67  ? 87  SER   R CB  1 
ATOM   222  O OG  . SER   A 1 143 ? 116.994 124.118 126.971 1.00 63.67  ? 87  SER   R OG  1 
ATOM   223  N N   . THR   A 1 144 ? 119.713 122.022 129.580 1.00 59.86  ? 88  THR   R N   1 
ATOM   224  C CA  . THR   A 1 144 ? 120.367 121.494 130.769 1.00 59.86  ? 88  THR   R CA  1 
ATOM   225  C C   . THR   A 1 144 ? 121.879 121.600 130.658 1.00 59.86  ? 88  THR   R C   1 
ATOM   226  O O   . THR   A 1 144 ? 122.555 121.801 131.669 1.00 59.86  ? 88  THR   R O   1 
ATOM   227  C CB  . THR   A 1 144 ? 119.952 120.044 131.004 1.00 59.86  ? 88  THR   R CB  1 
ATOM   228  O OG1 . THR   A 1 144 ? 118.535 119.979 131.199 1.00 59.86  ? 88  THR   R OG1 1 
ATOM   229  C CG2 . THR   A 1 144 ? 120.652 119.482 132.229 1.00 59.86  ? 88  THR   R CG2 1 
ATOM   230  N N   . ASP   A 1 145 ? 122.428 121.486 129.449 1.00 65.95  ? 89  ASP   R N   1 
ATOM   231  C CA  . ASP   A 1 145 ? 123.867 121.657 129.281 1.00 65.95  ? 89  ASP   R CA  1 
ATOM   232  C C   . ASP   A 1 145 ? 124.289 123.080 129.625 1.00 65.95  ? 89  ASP   R C   1 
ATOM   233  O O   . ASP   A 1 145 ? 125.306 123.296 130.294 1.00 65.95  ? 89  ASP   R O   1 
ATOM   234  C CB  . ASP   A 1 145 ? 124.270 121.304 127.851 1.00 65.95  ? 89  ASP   R CB  1 
ATOM   235  C CG  . ASP   A 1 145 ? 124.071 119.836 127.536 1.00 65.95  ? 89  ASP   R CG  1 
ATOM   236  O OD1 . ASP   A 1 145 ? 123.595 119.096 128.422 1.00 65.95  ? 89  ASP   R OD1 1 
ATOM   237  O OD2 . ASP   A 1 145 ? 124.391 119.420 126.402 1.00 65.95  ? 89  ASP   R OD2 1 
ATOM   238  N N   . THR   A 1 146 ? 123.515 124.069 129.171 1.00 63.92  ? 90  THR   R N   1 
ATOM   239  C CA  . THR   A 1 146 ? 123.817 125.459 129.493 1.00 63.92  ? 90  THR   R CA  1 
ATOM   240  C C   . THR   A 1 146 ? 123.758 125.688 130.997 1.00 63.92  ? 90  THR   R C   1 
ATOM   241  O O   . THR   A 1 146 ? 124.647 126.319 131.586 1.00 63.92  ? 90  THR   R O   1 
ATOM   242  C CB  . THR   A 1 146 ? 122.831 126.383 128.778 1.00 63.92  ? 90  THR   R CB  1 
ATOM   243  O OG1 . THR   A 1 146 ? 122.736 126.014 127.398 1.00 63.92  ? 90  THR   R OG1 1 
ATOM   244  C CG2 . THR   A 1 146 ? 123.285 127.823 128.874 1.00 63.92  ? 90  THR   R CG2 1 
ATOM   245  N N   . PHE   A 1 147 ? 122.706 125.173 131.636 1.00 60.32  ? 91  PHE   R N   1 
ATOM   246  C CA  . PHE   A 1 147 ? 122.579 125.335 133.079 1.00 60.32  ? 91  PHE   R CA  1 
ATOM   247  C C   . PHE   A 1 147 ? 123.734 124.664 133.806 1.00 60.32  ? 91  PHE   R C   1 
ATOM   248  O O   . PHE   A 1 147 ? 124.257 125.204 134.785 1.00 60.32  ? 91  PHE   R O   1 
ATOM   249  C CB  . PHE   A 1 147 ? 121.247 124.766 133.558 1.00 60.32  ? 91  PHE   R CB  1 
ATOM   250  C CG  . PHE   A 1 147 ? 120.061 125.583 133.151 1.00 60.32  ? 91  PHE   R CG  1 
ATOM   251  C CD1 . PHE   A 1 147 ? 119.920 126.884 133.591 1.00 60.32  ? 91  PHE   R CD1 1 
ATOM   252  C CD2 . PHE   A 1 147 ? 119.083 125.047 132.336 1.00 60.32  ? 91  PHE   R CD2 1 
ATOM   253  C CE1 . PHE   A 1 147 ? 118.829 127.636 133.221 1.00 60.32  ? 91  PHE   R CE1 1 
ATOM   254  C CE2 . PHE   A 1 147 ? 117.991 125.796 131.963 1.00 60.32  ? 91  PHE   R CE2 1 
ATOM   255  C CZ  . PHE   A 1 147 ? 117.863 127.090 132.406 1.00 60.32  ? 91  PHE   R CZ  1 
ATOM   256  N N   . LEU   A 1 148 ? 124.143 123.482 133.347 1.00 64.77  ? 92  LEU   R N   1 
ATOM   257  C CA  . LEU   A 1 148 ? 125.245 122.773 133.984 1.00 64.77  ? 92  LEU   R CA  1 
ATOM   258  C C   . LEU   A 1 148 ? 126.552 123.542 133.836 1.00 64.77  ? 92  LEU   R C   1 
ATOM   259  O O   . LEU   A 1 148 ? 127.352 123.608 134.774 1.00 64.77  ? 92  LEU   R O   1 
ATOM   260  C CB  . LEU   A 1 148 ? 125.364 121.371 133.389 1.00 64.77  ? 92  LEU   R CB  1 
ATOM   261  C CG  . LEU   A 1 148 ? 126.492 120.491 133.922 1.00 64.77  ? 92  LEU   R CG  1 
ATOM   262  C CD1 . LEU   A 1 148 ? 126.360 120.293 135.421 1.00 64.77  ? 92  LEU   R CD1 1 
ATOM   263  C CD2 . LEU   A 1 148 ? 126.486 119.158 133.199 1.00 64.77  ? 92  LEU   R CD2 1 
ATOM   264  N N   . LEU   A 1 149 ? 126.792 124.127 132.661 1.00 67.05  ? 93  LEU   R N   1 
ATOM   265  C CA  . LEU   A 1 149 ? 127.996 124.932 132.481 1.00 67.05  ? 93  LEU   R CA  1 
ATOM   266  C C   . LEU   A 1 149 ? 127.996 126.133 133.417 1.00 67.05  ? 93  LEU   R C   1 
ATOM   267  O O   . LEU   A 1 149 ? 129.016 126.444 134.049 1.00 67.05  ? 93  LEU   R O   1 
ATOM   268  C CB  . LEU   A 1 149 ? 128.109 125.393 131.028 1.00 67.05  ? 93  LEU   R CB  1 
ATOM   269  C CG  . LEU   A 1 149 ? 129.183 126.443 130.735 1.00 67.05  ? 93  LEU   R CG  1 
ATOM   270  C CD1 . LEU   A 1 149 ? 130.539 125.986 131.237 1.00 67.05  ? 93  LEU   R CD1 1 
ATOM   271  C CD2 . LEU   A 1 149 ? 129.240 126.741 129.247 1.00 67.05  ? 93  LEU   R CD2 1 
ATOM   272  N N   . HIS   A 1 150 ? 126.861 126.824 133.516 1.00 64.91  ? 94  HIS   R N   1 
ATOM   273  C CA  . HIS   A 1 150 ? 126.788 127.980 134.405 1.00 64.91  ? 94  HIS   R CA  1 
ATOM   274  C C   . HIS   A 1 150 ? 126.981 127.563 135.858 1.00 64.91  ? 94  HIS   R C   1 
ATOM   275  O O   . HIS   A 1 150 ? 127.650 128.255 136.634 1.00 64.91  ? 94  HIS   R O   1 
ATOM   276  C CB  . HIS   A 1 150 ? 125.456 128.701 134.212 1.00 64.91  ? 94  HIS   R CB  1 
ATOM   277  C CG  . HIS   A 1 150 ? 125.455 129.655 133.061 1.00 64.91  ? 94  HIS   R CG  1 
ATOM   278  N ND1 . HIS   A 1 150 ? 126.185 130.823 133.062 1.00 64.91  ? 94  HIS   R ND1 1 
ATOM   279  C CD2 . HIS   A 1 150 ? 124.830 129.604 131.862 1.00 64.91  ? 94  HIS   R CD2 1 
ATOM   280  C CE1 . HIS   A 1 150 ? 125.999 131.457 131.919 1.00 64.91  ? 94  HIS   R CE1 1 
ATOM   281  N NE2 . HIS   A 1 150 ? 125.180 130.738 131.173 1.00 64.91  ? 94  HIS   R NE2 1 
ATOM   282  N N   . LEU   A 1 151 ? 126.404 126.423 136.242 1.00 65.12  ? 95  LEU   R N   1 
ATOM   283  C CA  . LEU   A 1 151 ? 126.595 125.909 137.592 1.00 65.12  ? 95  LEU   R CA  1 
ATOM   284  C C   . LEU   A 1 151 ? 128.057 125.579 137.850 1.00 65.12  ? 95  LEU   R C   1 
ATOM   285  O O   . LEU   A 1 151 ? 128.572 125.825 138.944 1.00 65.12  ? 95  LEU   R O   1 
ATOM   286  C CB  . LEU   A 1 151 ? 125.719 124.674 137.807 1.00 65.12  ? 95  LEU   R CB  1 
ATOM   287  C CG  . LEU   A 1 151 ? 125.888 123.929 139.131 1.00 65.12  ? 95  LEU   R CG  1 
ATOM   288  C CD1 . LEU   A 1 151 ? 125.454 124.796 140.296 1.00 65.12  ? 95  LEU   R CD1 1 
ATOM   289  C CD2 . LEU   A 1 151 ? 125.099 122.634 139.108 1.00 65.12  ? 95  LEU   R CD2 1 
ATOM   290  N N   . ALA   A 1 152 ? 128.739 125.009 136.858 1.00 69.34  ? 96  ALA   R N   1 
ATOM   291  C CA  . ALA   A 1 152 ? 130.155 124.700 137.018 1.00 69.34  ? 96  ALA   R CA  1 
ATOM   292  C C   . ALA   A 1 152 ? 130.968 125.970 137.223 1.00 69.34  ? 96  ALA   R C   1 
ATOM   293  O O   . ALA   A 1 152 ? 131.857 126.020 138.080 1.00 69.34  ? 96  ALA   R O   1 
ATOM   294  C CB  . ALA   A 1 152 ? 130.663 123.926 135.803 1.00 69.34  ? 96  ALA   R CB  1 
ATOM   295  N N   . VAL   A 1 153 ? 130.673 127.012 136.444 1.00 69.77  ? 97  VAL   R N   1 
ATOM   296  C CA  . VAL   A 1 153 ? 131.384 128.280 136.611 1.00 69.77  ? 97  VAL   R CA  1 
ATOM   297  C C   . VAL   A 1 153 ? 131.136 128.842 138.007 1.00 69.77  ? 97  VAL   R C   1 
ATOM   298  O O   . VAL   A 1 153 ? 132.065 129.284 138.702 1.00 69.77  ? 97  VAL   R O   1 
ATOM   299  C CB  . VAL   A 1 153 ? 130.959 129.279 135.519 1.00 69.77  ? 97  VAL   R CB  1 
ATOM   300  C CG1 . VAL   A 1 153 ? 131.386 130.689 135.890 1.00 69.77  ? 97  VAL   R CG1 1 
ATOM   301  C CG2 . VAL   A 1 153 ? 131.547 128.876 134.177 1.00 69.77  ? 97  VAL   R CG2 1 
ATOM   302  N N   . ALA   A 1 154 ? 129.873 128.833 138.437 1.00 71.86  ? 98  ALA   R N   1 
ATOM   303  C CA  . ALA   A 1 154 ? 129.531 129.372 139.748 1.00 71.86  ? 98  ALA   R CA  1 
ATOM   304  C C   . ALA   A 1 154 ? 130.237 128.601 140.854 1.00 71.86  ? 98  ALA   R C   1 
ATOM   305  O O   . ALA   A 1 154 ? 130.771 129.193 141.798 1.00 71.86  ? 98  ALA   R O   1 
ATOM   306  C CB  . ALA   A 1 154 ? 128.017 129.336 139.951 1.00 71.86  ? 98  ALA   R CB  1 
ATOM   307  N N   . ASP   A 1 155 ? 130.256 127.273 140.752 1.00 74.21  ? 99  ASP   R N   1 
ATOM   308  C CA  . ASP   A 1 155 ? 130.902 126.466 141.776 1.00 74.21  ? 99  ASP   R CA  1 
ATOM   309  C C   . ASP   A 1 155 ? 132.411 126.657 141.772 1.00 74.21  ? 99  ASP   R C   1 
ATOM   310  O O   . ASP   A 1 155 ? 133.034 126.624 142.835 1.00 74.21  ? 99  ASP   R O   1 
ATOM   311  C CB  . ASP   A 1 155 ? 130.550 124.994 141.581 1.00 74.21  ? 99  ASP   R CB  1 
ATOM   312  C CG  . ASP   A 1 155 ? 129.108 124.694 141.922 1.00 74.21  ? 99  ASP   R CG  1 
ATOM   313  O OD1 . ASP   A 1 155 ? 128.694 124.978 143.065 1.00 74.21  ? 99  ASP   R OD1 1 
ATOM   314  O OD2 . ASP   A 1 155 ? 128.386 124.173 141.049 1.00 74.21  ? 99  ASP   R OD2 1 
ATOM   315  N N   . THR   A 1 156 ? 133.019 126.848 140.600 1.00 77.42  ? 100 THR   R N   1 
ATOM   316  C CA  . THR   A 1 156 ? 134.446 127.152 140.561 1.00 77.42  ? 100 THR   R CA  1 
ATOM   317  C C   . THR   A 1 156 ? 134.736 128.450 141.301 1.00 77.42  ? 100 THR   R C   1 
ATOM   318  O O   . THR   A 1 156 ? 135.645 128.519 142.143 1.00 77.42  ? 100 THR   R O   1 
ATOM   319  C CB  . THR   A 1 156 ? 134.922 127.245 139.112 1.00 77.42  ? 100 THR   R CB  1 
ATOM   320  O OG1 . THR   A 1 156 ? 134.447 126.113 138.376 1.00 77.42  ? 100 THR   R OG1 1 
ATOM   321  C CG2 . THR   A 1 156 ? 136.440 127.287 139.052 1.00 77.42  ? 100 THR   R CG2 1 
ATOM   322  N N   . LEU   A 1 157 ? 133.951 129.490 141.016 1.00 77.92  ? 101 LEU   R N   1 
ATOM   323  C CA  . LEU   A 1 157 ? 134.142 130.758 141.711 1.00 77.92  ? 101 LEU   R CA  1 
ATOM   324  C C   . LEU   A 1 157 ? 133.940 130.587 143.211 1.00 77.92  ? 101 LEU   R C   1 
ATOM   325  O O   . LEU   A 1 157 ? 134.683 131.153 144.020 1.00 77.92  ? 101 LEU   R O   1 
ATOM   326  C CB  . LEU   A 1 157 ? 133.186 131.813 141.153 1.00 77.92  ? 101 LEU   R CB  1 
ATOM   327  C CG  . LEU   A 1 157 ? 133.459 132.336 139.740 1.00 77.92  ? 101 LEU   R CG  1 
ATOM   328  C CD1 . LEU   A 1 157 ? 132.644 133.593 139.482 1.00 77.92  ? 101 LEU   R CD1 1 
ATOM   329  C CD2 . LEU   A 1 157 ? 134.940 132.612 139.515 1.00 77.92  ? 101 LEU   R CD2 1 
ATOM   330  N N   . LEU   A 1 158 ? 132.936 129.801 143.601 1.00 78.35  ? 102 LEU   R N   1 
ATOM   331  C CA  . LEU   A 1 158 ? 132.642 129.602 145.014 1.00 78.35  ? 102 LEU   R CA  1 
ATOM   332  C C   . LEU   A 1 158 ? 133.738 128.827 145.736 1.00 78.35  ? 102 LEU   R C   1 
ATOM   333  O O   . LEU   A 1 158 ? 134.047 129.149 146.888 1.00 78.35  ? 102 LEU   R O   1 
ATOM   334  C CB  . LEU   A 1 158 ? 131.303 128.879 145.159 1.00 78.35  ? 102 LEU   R CB  1 
ATOM   335  C CG  . LEU   A 1 158 ? 130.760 128.678 146.572 1.00 78.35  ? 102 LEU   R CG  1 
ATOM   336  C CD1 . LEU   A 1 158 ? 130.700 129.995 147.318 1.00 78.35  ? 102 LEU   R CD1 1 
ATOM   337  C CD2 . LEU   A 1 158 ? 129.384 128.038 146.511 1.00 78.35  ? 102 LEU   R CD2 1 
ATOM   338  N N   . VAL   A 1 159 ? 134.329 127.822 145.095 1.00 81.83  ? 103 VAL   R N   1 
ATOM   339  C CA  . VAL   A 1 159 ? 135.400 127.050 145.720 1.00 81.83  ? 103 VAL   R CA  1 
ATOM   340  C C   . VAL   A 1 159 ? 136.700 127.835 145.743 1.00 81.83  ? 103 VAL   R C   1 
ATOM   341  O O   . VAL   A 1 159 ? 137.588 127.547 146.548 1.00 81.83  ? 103 VAL   R O   1 
ATOM   342  C CB  . VAL   A 1 159 ? 135.588 125.694 145.010 1.00 81.83  ? 103 VAL   R CB  1 
ATOM   343  C CG1 . VAL   A 1 159 ? 134.327 124.863 145.107 1.00 81.83  ? 103 VAL   R CG1 1 
ATOM   344  C CG2 . VAL   A 1 159 ? 136.008 125.892 143.563 1.00 81.83  ? 103 VAL   R CG2 1 
ATOM   345  N N   . LEU   A 1 160 ? 136.844 128.831 144.867 1.00 82.77  ? 104 LEU   R N   1 
ATOM   346  C CA  . LEU   A 1 160 ? 138.048 129.650 144.920 1.00 82.77  ? 104 LEU   R CA  1 
ATOM   347  C C   . LEU   A 1 160 ? 138.251 130.284 146.292 1.00 82.77  ? 104 LEU   R C   1 
ATOM   348  O O   . LEU   A 1 160 ? 139.382 130.644 146.636 1.00 82.77  ? 104 LEU   R O   1 
ATOM   349  C CB  . LEU   A 1 160 ? 137.996 130.742 143.848 1.00 82.77  ? 104 LEU   R CB  1 
ATOM   350  C CG  . LEU   A 1 160 ? 138.704 130.417 142.530 1.00 82.77  ? 104 LEU   R CG  1 
ATOM   351  C CD1 . LEU   A 1 160 ? 138.380 131.468 141.484 1.00 82.77  ? 104 LEU   R CD1 1 
ATOM   352  C CD2 . LEU   A 1 160 ? 140.208 130.309 142.725 1.00 82.77  ? 104 LEU   R CD2 1 
ATOM   353  N N   . THR   A 1 161 ? 137.186 130.427 147.083 1.00 85.58  ? 105 THR   R N   1 
ATOM   354  C CA  . THR   A 1 161 ? 137.276 131.091 148.379 1.00 85.58  ? 105 THR   R CA  1 
ATOM   355  C C   . THR   A 1 161 ? 137.513 130.132 149.539 1.00 85.58  ? 105 THR   R C   1 
ATOM   356  O O   . THR   A 1 161 ? 137.591 130.580 150.689 1.00 85.58  ? 105 THR   R O   1 
ATOM   357  C CB  . THR   A 1 161 ? 135.996 131.887 148.652 1.00 85.58  ? 105 THR   R CB  1 
ATOM   358  O OG1 . THR   A 1 161 ? 134.942 130.990 149.024 1.00 85.58  ? 105 THR   R OG1 1 
ATOM   359  C CG2 . THR   A 1 161 ? 135.576 132.668 147.416 1.00 85.58  ? 105 THR   R CG2 1 
ATOM   360  N N   . LEU   A 1 162 ? 137.626 128.831 149.279 1.00 88.81  ? 106 LEU   R N   1 
ATOM   361  C CA  . LEU   A 1 162 ? 137.787 127.848 150.345 1.00 88.81  ? 106 LEU   R CA  1 
ATOM   362  C C   . LEU   A 1 162 ? 138.964 128.175 151.260 1.00 88.81  ? 106 LEU   R C   1 
ATOM   363  O O   . LEU   A 1 162 ? 138.803 128.167 152.488 1.00 88.81  ? 106 LEU   R O   1 
ATOM   364  C CB  . LEU   A 1 162 ? 137.958 126.447 149.752 1.00 88.81  ? 106 LEU   R CB  1 
ATOM   365  C CG  . LEU   A 1 162 ? 137.693 125.259 150.684 1.00 88.81  ? 106 LEU   R CG  1 
ATOM   366  C CD1 . LEU   A 1 162 ? 137.658 123.968 149.885 1.00 88.81  ? 106 LEU   R CD1 1 
ATOM   367  C CD2 . LEU   A 1 162 ? 138.736 125.162 151.786 1.00 88.81  ? 106 LEU   R CD2 1 
ATOM   368  N N   . PRO   A 1 163 ? 140.162 128.447 150.725 1.00 90.00  ? 107 PRO   R N   1 
ATOM   369  C CA  . PRO   A 1 163 ? 141.294 128.739 151.617 1.00 90.00  ? 107 PRO   R CA  1 
ATOM   370  C C   . PRO   A 1 163 ? 141.008 129.911 152.537 1.00 90.00  ? 107 PRO   R C   1 
ATOM   371  O O   . PRO   A 1 163 ? 141.389 129.899 153.712 1.00 90.00  ? 107 PRO   R O   1 
ATOM   372  C CB  . PRO   A 1 163 ? 142.445 129.049 150.649 1.00 90.00  ? 107 PRO   R CB  1 
ATOM   373  C CG  . PRO   A 1 163 ? 141.806 129.285 149.327 1.00 90.00  ? 107 PRO   R CG  1 
ATOM   374  C CD  . PRO   A 1 163 ? 140.579 128.442 149.314 1.00 90.00  ? 107 PRO   R CD  1 
ATOM   375  N N   . LEU   A 1 164 ? 140.329 130.930 152.009 1.00 90.99  ? 108 LEU   R N   1 
ATOM   376  C CA  . LEU   A 1 164 ? 140.004 132.099 152.817 1.00 90.99  ? 108 LEU   R CA  1 
ATOM   377  C C   . LEU   A 1 164 ? 139.119 131.717 153.995 1.00 90.99  ? 108 LEU   R C   1 
ATOM   378  O O   . LEU   A 1 164 ? 139.389 132.098 155.139 1.00 90.99  ? 108 LEU   R O   1 
ATOM   379  C CB  . LEU   A 1 164 ? 139.316 133.155 151.951 1.00 90.99  ? 108 LEU   R CB  1 
ATOM   380  C CG  . LEU   A 1 164 ? 140.099 133.705 150.758 1.00 90.99  ? 108 LEU   R CG  1 
ATOM   381  C CD1 . LEU   A 1 164 ? 139.575 135.081 150.386 1.00 90.99  ? 108 LEU   R CD1 1 
ATOM   382  C CD2 . LEU   A 1 164 ? 141.593 133.758 151.046 1.00 90.99  ? 108 LEU   R CD2 1 
ATOM   383  N N   . TRP   A 1 165 ? 138.052 130.960 153.732 1.00 89.66  ? 109 TRP   R N   1 
ATOM   384  C CA  . TRP   A 1 165 ? 137.148 130.556 154.802 1.00 89.66  ? 109 TRP   R CA  1 
ATOM   385  C C   . TRP   A 1 165 ? 137.873 129.697 155.826 1.00 89.66  ? 109 TRP   R C   1 
ATOM   386  O O   . TRP   A 1 165 ? 137.685 129.852 157.037 1.00 89.66  ? 109 TRP   R O   1 
ATOM   387  C CB  . TRP   A 1 165 ? 135.950 129.798 154.227 1.00 89.66  ? 109 TRP   R CB  1 
ATOM   388  C CG  . TRP   A 1 165 ? 135.137 129.105 155.283 1.00 89.66  ? 109 TRP   R CG  1 
ATOM   389  C CD1 . TRP   A 1 165 ? 134.231 129.680 156.124 1.00 89.66  ? 109 TRP   R CD1 1 
ATOM   390  C CD2 . TRP   A 1 165 ? 135.165 127.711 155.617 1.00 89.66  ? 109 TRP   R CD2 1 
ATOM   391  N NE1 . TRP   A 1 165 ? 133.690 128.732 156.958 1.00 89.66  ? 109 TRP   R NE1 1 
ATOM   392  C CE2 . TRP   A 1 165 ? 134.247 127.515 156.666 1.00 89.66  ? 109 TRP   R CE2 1 
ATOM   393  C CE3 . TRP   A 1 165 ? 135.875 126.611 155.129 1.00 89.66  ? 109 TRP   R CE3 1 
ATOM   394  C CZ2 . TRP   A 1 165 ? 134.020 126.265 157.235 1.00 89.66  ? 109 TRP   R CZ2 1 
ATOM   395  C CZ3 . TRP   A 1 165 ? 135.647 125.370 155.696 1.00 89.66  ? 109 TRP   R CZ3 1 
ATOM   396  C CH2 . TRP   A 1 165 ? 134.729 125.208 156.737 1.00 89.66  ? 109 TRP   R CH2 1 
ATOM   397  N N   . ALA   A 1 166 ? 138.701 128.765 155.351 1.00 92.52  ? 110 ALA   R N   1 
ATOM   398  C CA  . ALA   A 1 166 ? 139.427 127.896 156.270 1.00 92.52  ? 110 ALA   R CA  1 
ATOM   399  C C   . ALA   A 1 166 ? 140.343 128.708 157.175 1.00 92.52  ? 110 ALA   R C   1 
ATOM   400  O O   . ALA   A 1 166 ? 140.351 128.525 158.398 1.00 92.52  ? 110 ALA   R O   1 
ATOM   401  C CB  . ALA   A 1 166 ? 140.226 126.857 155.484 1.00 92.52  ? 110 ALA   R CB  1 
ATOM   402  N N   . VAL   A 1 167 ? 141.116 129.624 156.590 1.00 93.38  ? 111 VAL   R N   1 
ATOM   403  C CA  . VAL   A 1 167 ? 142.038 130.438 157.379 1.00 93.38  ? 111 VAL   R CA  1 
ATOM   404  C C   . VAL   A 1 167 ? 141.264 131.289 158.375 1.00 93.38  ? 111 VAL   R C   1 
ATOM   405  O O   . VAL   A 1 167 ? 141.653 131.427 159.540 1.00 93.38  ? 111 VAL   R O   1 
ATOM   406  C CB  . VAL   A 1 167 ? 142.910 131.304 156.453 1.00 93.38  ? 111 VAL   R CB  1 
ATOM   407  C CG1 . VAL   A 1 167 ? 143.626 132.383 157.246 1.00 93.38  ? 111 VAL   R CG1 1 
ATOM   408  C CG2 . VAL   A 1 167 ? 143.909 130.434 155.707 1.00 93.38  ? 111 VAL   R CG2 1 
ATOM   409  N N   . ASP   A 1 168 ? 140.152 131.875 157.928 1.00 96.26  ? 112 ASP   R N   1 
ATOM   410  C CA  . ASP   A 1 168 ? 139.357 132.725 158.806 1.00 96.26  ? 112 ASP   R CA  1 
ATOM   411  C C   . ASP   A 1 168 ? 138.817 131.932 159.989 1.00 96.26  ? 112 ASP   R C   1 
ATOM   412  O O   . ASP   A 1 168 ? 138.881 132.384 161.137 1.00 96.26  ? 112 ASP   R O   1 
ATOM   413  C CB  . ASP   A 1 168 ? 138.217 133.361 158.011 1.00 96.26  ? 112 ASP   R CB  1 
ATOM   414  C CG  . ASP   A 1 168 ? 137.171 134.007 158.897 1.00 96.26  ? 112 ASP   R CG  1 
ATOM   415  O OD1 . ASP   A 1 168 ? 136.402 133.272 159.552 1.00 96.26  ? 112 ASP   R OD1 1 
ATOM   416  O OD2 . ASP   A 1 168 ? 137.118 135.253 158.938 1.00 96.26  ? 112 ASP   R OD2 1 
ATOM   417  N N   . ALA   A 1 169 ? 138.278 130.741 159.725 1.00 95.48  ? 113 ALA   R N   1 
ATOM   418  C CA  . ALA   A 1 169 ? 137.726 129.927 160.801 1.00 95.48  ? 113 ALA   R CA  1 
ATOM   419  C C   . ALA   A 1 169 ? 138.816 129.405 161.725 1.00 95.48  ? 113 ALA   R C   1 
ATOM   420  O O   . ALA   A 1 169 ? 138.566 129.170 162.912 1.00 95.48  ? 113 ALA   R O   1 
ATOM   421  C CB  . ALA   A 1 169 ? 136.923 128.764 160.217 1.00 95.48  ? 113 ALA   R CB  1 
ATOM   422  N N   . ALA   A 1 170 ? 140.029 129.217 161.206 1.00 96.55  ? 114 ALA   R N   1 
ATOM   423  C CA  . ALA   A 1 170 ? 141.114 128.669 162.010 1.00 96.55  ? 114 ALA   R CA  1 
ATOM   424  C C   . ALA   A 1 170 ? 141.703 129.690 162.976 1.00 96.55  ? 114 ALA   R C   1 
ATOM   425  O O   . ALA   A 1 170 ? 141.679 129.465 164.191 1.00 96.55  ? 114 ALA   R O   1 
ATOM   426  C CB  . ALA   A 1 170 ? 142.217 128.122 161.100 1.00 96.55  ? 114 ALA   R CB  1 
ATOM   427  N N   . VAL   A 1 171 ? 142.230 130.811 162.474 1.00 99.82  ? 115 VAL   R N   1 
ATOM   428  C CA  . VAL   A 1 171 ? 142.899 131.805 163.304 1.00 99.82  ? 115 VAL   R CA  1 
ATOM   429  C C   . VAL   A 1 171 ? 142.129 133.120 163.336 1.00 99.82  ? 115 VAL   R C   1 
ATOM   430  O O   . VAL   A 1 171 ? 141.557 133.491 164.365 1.00 99.82  ? 115 VAL   R O   1 
ATOM   431  C CB  . VAL   A 1 171 ? 144.351 132.042 162.831 1.00 99.82  ? 115 VAL   R CB  1 
ATOM   432  C CG1 . VAL   A 1 171 ? 144.999 133.152 163.641 1.00 99.82  ? 115 VAL   R CG1 1 
ATOM   433  C CG2 . VAL   A 1 171 ? 145.162 130.758 162.925 1.00 99.82  ? 115 VAL   R CG2 1 
ATOM   434  N N   . GLN   A 1 172 ? 142.091 133.834 162.209 1.00 99.77  ? 116 GLN   R N   1 
ATOM   435  C CA  . GLN   A 1 172 ? 141.365 135.098 162.121 1.00 99.77  ? 116 GLN   R CA  1 
ATOM   436  C C   . GLN   A 1 172 ? 141.484 135.687 160.721 1.00 99.77  ? 116 GLN   R C   1 
ATOM   437  O O   . GLN   A 1 172 ? 142.397 135.333 159.969 1.00 99.77  ? 116 GLN   R O   1 
ATOM   438  C CB  . GLN   A 1 172 ? 141.888 136.114 163.143 1.00 99.77  ? 116 GLN   R CB  1 
ATOM   439  C CG  . GLN   A 1 172 ? 143.282 136.636 162.840 1.00 99.77  ? 116 GLN   R CG  1 
ATOM   440  C CD  . GLN   A 1 172 ? 144.005 137.136 164.075 1.00 99.77  ? 116 GLN   R CD  1 
ATOM   441  O OE1 . GLN   A 1 172 ? 143.523 138.030 164.770 1.00 99.77  ? 116 GLN   R OE1 1 
ATOM   442  N NE2 . GLN   A 1 172 ? 145.178 136.574 164.344 1.00 99.77  ? 116 GLN   R NE2 1 
ATOM   443  N N   . TRP   A 1 173 ? 140.581 136.599 160.372 1.00 95.33  ? 117 TRP   R N   1 
ATOM   444  C CA  . TRP   A 1 173 ? 140.721 137.384 159.152 1.00 95.33  ? 117 TRP   R CA  1 
ATOM   445  C C   . TRP   A 1 173 ? 141.873 138.365 159.320 1.00 95.33  ? 117 TRP   R C   1 
ATOM   446  O O   . TRP   A 1 173 ? 141.921 139.110 160.304 1.00 95.33  ? 117 TRP   R O   1 
ATOM   447  C CB  . TRP   A 1 173 ? 139.426 138.128 158.846 1.00 95.33  ? 117 TRP   R CB  1 
ATOM   448  C CG  . TRP   A 1 173 ? 139.331 138.621 157.440 1.00 95.33  ? 117 TRP   R CG  1 
ATOM   449  C CD1 . TRP   A 1 173 ? 139.602 139.880 156.997 1.00 95.33  ? 117 TRP   R CD1 1 
ATOM   450  C CD2 . TRP   A 1 173 ? 138.931 137.868 156.290 1.00 95.33  ? 117 TRP   R CD2 1 
ATOM   451  N NE1 . TRP   A 1 173 ? 139.395 139.958 155.641 1.00 95.33  ? 117 TRP   R NE1 1 
ATOM   452  C CE2 . TRP   A 1 173 ? 138.984 138.734 155.185 1.00 95.33  ? 117 TRP   R CE2 1 
ATOM   453  C CE3 . TRP   A 1 173 ? 138.535 136.545 156.090 1.00 95.33  ? 117 TRP   R CE3 1 
ATOM   454  C CZ2 . TRP   A 1 173 ? 138.651 138.322 153.901 1.00 95.33  ? 117 TRP   R CZ2 1 
ATOM   455  C CZ3 . TRP   A 1 173 ? 138.208 136.136 154.812 1.00 95.33  ? 117 TRP   R CZ3 1 
ATOM   456  C CH2 . TRP   A 1 173 ? 138.270 137.020 153.733 1.00 95.33  ? 117 TRP   R CH2 1 
ATOM   457  N N   . VAL   A 1 174 ? 142.801 138.365 158.365 1.00 96.10  ? 118 VAL   R N   1 
ATOM   458  C CA  . VAL   A 1 174 ? 143.979 139.221 158.445 1.00 96.10  ? 118 VAL   R CA  1 
ATOM   459  C C   . VAL   A 1 174 ? 144.211 139.918 157.110 1.00 96.10  ? 118 VAL   R C   1 
ATOM   460  O O   . VAL   A 1 174 ? 145.273 140.509 156.885 1.00 96.10  ? 118 VAL   R O   1 
ATOM   461  C CB  . VAL   A 1 174 ? 145.215 138.405 158.863 1.00 96.10  ? 118 VAL   R CB  1 
ATOM   462  C CG1 . VAL   A 1 174 ? 145.053 137.904 160.287 1.00 96.10  ? 118 VAL   R CG1 1 
ATOM   463  C CG2 . VAL   A 1 174 ? 145.435 137.242 157.906 1.00 96.10  ? 118 VAL   R CG2 1 
ATOM   464  N N   . PHE   A 1 175 ? 143.222 139.862 156.220 1.00 94.41  ? 119 PHE   R N   1 
ATOM   465  C CA  . PHE   A 1 175 ? 143.354 140.409 154.878 1.00 94.41  ? 119 PHE   R CA  1 
ATOM   466  C C   . PHE   A 1 175 ? 142.685 141.765 154.707 1.00 94.41  ? 119 PHE   R C   1 
ATOM   467  O O   . PHE   A 1 175 ? 142.652 142.283 153.585 1.00 94.41  ? 119 PHE   R O   1 
ATOM   468  C CB  . PHE   A 1 175 ? 142.776 139.429 153.851 1.00 94.41  ? 119 PHE   R CB  1 
ATOM   469  C CG  . PHE   A 1 175 ? 143.143 137.995 154.102 1.00 94.41  ? 119 PHE   R CG  1 
ATOM   470  C CD1 . PHE   A 1 175 ? 144.459 137.632 154.330 1.00 94.41  ? 119 PHE   R CD1 1 
ATOM   471  C CD2 . PHE   A 1 175 ? 142.172 137.010 154.101 1.00 94.41  ? 119 PHE   R CD2 1 
ATOM   472  C CE1 . PHE   A 1 175 ? 144.797 136.312 154.557 1.00 94.41  ? 119 PHE   R CE1 1 
ATOM   473  C CE2 . PHE   A 1 175 ? 142.505 135.690 154.328 1.00 94.41  ? 119 PHE   R CE2 1 
ATOM   474  C CZ  . PHE   A 1 175 ? 143.818 135.341 154.556 1.00 94.41  ? 119 PHE   R CZ  1 
ATOM   475  N N   . GLY   A 1 176 ? 142.150 142.353 155.772 1.00 93.43  ? 120 GLY   R N   1 
ATOM   476  C CA  . GLY   A 1 176 ? 141.528 143.658 155.675 1.00 93.43  ? 120 GLY   R CA  1 
ATOM   477  C C   . GLY   A 1 176 ? 140.072 143.590 155.261 1.00 93.43  ? 120 GLY   R C   1 
ATOM   478  O O   . GLY   A 1 176 ? 139.532 142.547 154.882 1.00 93.43  ? 120 GLY   R O   1 
ATOM   479  N N   . SER   A 1 177 ? 139.422 144.753 155.338 1.00 89.62  ? 121 SER   R N   1 
ATOM   480  C CA  . SER   A 1 177 ? 137.990 144.833 155.070 1.00 89.62  ? 121 SER   R CA  1 
ATOM   481  C C   . SER   A 1 177 ? 137.667 144.805 153.580 1.00 89.62  ? 121 SER   R C   1 
ATOM   482  O O   . SER   A 1 177 ? 136.627 144.264 153.190 1.00 89.62  ? 121 SER   R O   1 
ATOM   483  C CB  . SER   A 1 177 ? 137.415 146.098 155.706 1.00 89.62  ? 121 SER   R CB  1 
ATOM   484  O OG  . SER   A 1 177 ? 138.233 147.222 155.435 1.00 89.62  ? 121 SER   R OG  1 
ATOM   485  N N   . GLY   A 1 178 ? 138.522 145.386 152.737 1.00 91.18  ? 122 GLY   R N   1 
ATOM   486  C CA  . GLY   A 1 178 ? 138.241 145.385 151.308 1.00 91.18  ? 122 GLY   R CA  1 
ATOM   487  C C   . GLY   A 1 178 ? 138.169 143.981 150.738 1.00 91.18  ? 122 GLY   R C   1 
ATOM   488  O O   . GLY   A 1 178 ? 137.263 143.648 149.961 1.00 91.18  ? 122 GLY   R O   1 
ATOM   489  N N   . LEU   A 1 179 ? 139.132 143.137 151.113 1.00 92.22  ? 123 LEU   R N   1 
ATOM   490  C CA  . LEU   A 1 179 ? 139.103 141.756 150.656 1.00 92.22  ? 123 LEU   R CA  1 
ATOM   491  C C   . LEU   A 1 179 ? 137.876 141.043 151.208 1.00 92.22  ? 123 LEU   R C   1 
ATOM   492  O O   . LEU   A 1 179 ? 137.299 140.182 150.539 1.00 92.22  ? 123 LEU   R O   1 
ATOM   493  C CB  . LEU   A 1 179 ? 140.395 141.041 151.056 1.00 92.22  ? 123 LEU   R CB  1 
ATOM   494  C CG  . LEU   A 1 179 ? 140.651 139.707 150.345 1.00 92.22  ? 123 LEU   R CG  1 
ATOM   495  C CD1 . LEU   A 1 179 ? 142.128 139.558 150.029 1.00 92.22  ? 123 LEU   R CD1 1 
ATOM   496  C CD2 . LEU   A 1 179 ? 140.176 138.525 151.166 1.00 92.22  ? 123 LEU   R CD2 1 
ATOM   497  N N   . CYS   A 1 180 ? 137.445 141.409 152.416 1.00 90.83  ? 124 CYS   R N   1 
ATOM   498  C CA  . CYS   A 1 180 ? 136.146 140.978 152.916 1.00 90.83  ? 124 CYS   R CA  1 
ATOM   499  C C   . CYS   A 1 180 ? 135.002 141.331 151.980 1.00 90.83  ? 124 CYS   R C   1 
ATOM   500  O O   . CYS   A 1 180 ? 134.189 140.467 151.649 1.00 90.83  ? 124 CYS   R O   1 
ATOM   501  C CB  . CYS   A 1 180 ? 135.854 141.579 154.288 1.00 90.83  ? 124 CYS   R CB  1 
ATOM   502  S SG  . CYS   A 1 180 ? 136.350 140.600 155.702 1.00 90.83  ? 124 CYS   R SG  1 
ATOM   503  N N   . LYS   A 1 181 ? 134.898 142.594 151.577 1.00 86.51  ? 125 LYS   R N   1 
ATOM   504  C CA  . LYS   A 1 181 ? 133.780 142.990 150.732 1.00 86.51  ? 125 LYS   R CA  1 
ATOM   505  C C   . LYS   A 1 181 ? 133.797 142.171 149.450 1.00 86.51  ? 125 LYS   R C   1 
ATOM   506  O O   . LYS   A 1 181 ? 132.767 141.620 149.037 1.00 86.51  ? 125 LYS   R O   1 
ATOM   507  C CB  . LYS   A 1 181 ? 133.833 144.484 150.413 1.00 86.51  ? 125 LYS   R CB  1 
ATOM   508  C CG  . LYS   A 1 181 ? 133.485 145.385 151.590 1.00 86.51  ? 125 LYS   R CG  1 
ATOM   509  C CD  . LYS   A 1 181 ? 134.449 146.553 151.712 1.00 86.51  ? 125 LYS   R CD  1 
ATOM   510  C CE  . LYS   A 1 181 ? 134.370 147.197 153.083 1.00 86.51  ? 125 LYS   R CE  1 
ATOM   511  N NZ  . LYS   A 1 181 ? 135.386 148.272 153.248 1.00 86.51  ? 125 LYS   R NZ  1 
ATOM   512  N N   . VAL   A 1 182 ? 134.972 142.059 148.835 1.00 86.57  ? 126 VAL   R N   1 
ATOM   513  C CA  . VAL   A 1 182 ? 135.079 141.376 147.549 1.00 86.57  ? 126 VAL   R CA  1 
ATOM   514  C C   . VAL   A 1 182 ? 134.714 139.903 147.706 1.00 86.57  ? 126 VAL   R C   1 
ATOM   515  O O   . VAL   A 1 182 ? 133.898 139.369 146.943 1.00 86.57  ? 126 VAL   R O   1 
ATOM   516  C CB  . VAL   A 1 182 ? 136.489 141.530 146.953 1.00 86.57  ? 126 VAL   R CB  1 
ATOM   517  C CG1 . VAL   A 1 182 ? 136.598 140.747 145.658 1.00 86.57  ? 126 VAL   R CG1 1 
ATOM   518  C CG2 . VAL   A 1 182 ? 136.807 142.998 146.722 1.00 86.57  ? 126 VAL   R CG2 1 
ATOM   519  N N   . ALA   A 1 183 ? 135.311 139.235 148.697 1.00 85.79  ? 127 ALA   R N   1 
ATOM   520  C CA  . ALA   A 1 183 ? 135.072 137.808 148.881 1.00 85.79  ? 127 ALA   R CA  1 
ATOM   521  C C   . ALA   A 1 183 ? 133.626 137.532 149.260 1.00 85.79  ? 127 ALA   R C   1 
ATOM   522  O O   . ALA   A 1 183 ? 133.035 136.552 148.799 1.00 85.79  ? 127 ALA   R O   1 
ATOM   523  C CB  . ALA   A 1 183 ? 136.017 137.253 149.945 1.00 85.79  ? 127 ALA   R CB  1 
ATOM   524  N N   . GLY   A 1 184 ? 133.041 138.373 150.114 1.00 83.63  ? 128 GLY   R N   1 
ATOM   525  C CA  . GLY   A 1 184 ? 131.655 138.174 150.496 1.00 83.63  ? 128 GLY   R CA  1 
ATOM   526  C C   . GLY   A 1 184 ? 130.710 138.331 149.323 1.00 83.63  ? 128 GLY   R C   1 
ATOM   527  O O   . GLY   A 1 184 ? 129.767 137.552 149.160 1.00 83.63  ? 128 GLY   R O   1 
ATOM   528  N N   . ALA   A 1 185 ? 130.946 139.345 148.487 1.00 81.00  ? 129 ALA   R N   1 
ATOM   529  C CA  . ALA   A 1 185 ? 130.127 139.497 147.292 1.00 81.00  ? 129 ALA   R CA  1 
ATOM   530  C C   . ALA   A 1 185 ? 130.270 138.283 146.386 1.00 81.00  ? 129 ALA   R C   1 
ATOM   531  O O   . ALA   A 1 185 ? 129.275 137.741 145.889 1.00 81.00  ? 129 ALA   R O   1 
ATOM   532  C CB  . ALA   A 1 185 ? 130.514 140.775 146.550 1.00 81.00  ? 129 ALA   R CB  1 
ATOM   533  N N   . LEU   A 1 186 ? 131.506 137.832 146.173 1.00 80.25  ? 130 LEU   R N   1 
ATOM   534  C CA  . LEU   A 1 186 ? 131.757 136.648 145.363 1.00 80.25  ? 130 LEU   R CA  1 
ATOM   535  C C   . LEU   A 1 186 ? 130.943 135.474 145.886 1.00 80.25  ? 130 LEU   R C   1 
ATOM   536  O O   . LEU   A 1 186 ? 130.212 134.818 145.131 1.00 80.25  ? 130 LEU   R O   1 
ATOM   537  C CB  . LEU   A 1 186 ? 133.247 136.296 145.382 1.00 80.25  ? 130 LEU   R CB  1 
ATOM   538  C CG  . LEU   A 1 186 ? 134.076 136.510 144.115 1.00 80.25  ? 130 LEU   R CG  1 
ATOM   539  C CD1 . LEU   A 1 186 ? 135.514 136.095 144.380 1.00 80.25  ? 130 LEU   R CD1 1 
ATOM   540  C CD2 . LEU   A 1 186 ? 133.516 135.735 142.935 1.00 80.25  ? 130 LEU   R CD2 1 
ATOM   541  N N   . PHE   A 1 187 ? 131.067 135.214 147.187 1.00 81.24  ? 131 PHE   R N   1 
ATOM   542  C CA  . PHE   A 1 187 ? 130.438 134.044 147.783 1.00 81.24  ? 131 PHE   R CA  1 
ATOM   543  C C   . PHE   A 1 187 ? 128.923 134.124 147.690 1.00 81.24  ? 131 PHE   R C   1 
ATOM   544  O O   . PHE   A 1 187 ? 128.263 133.144 147.343 1.00 81.24  ? 131 PHE   R O   1 
ATOM   545  C CB  . PHE   A 1 187 ? 130.878 133.894 149.239 1.00 81.24  ? 131 PHE   R CB  1 
ATOM   546  C CG  . PHE   A 1 187 ? 130.616 132.532 149.803 1.00 81.24  ? 131 PHE   R CG  1 
ATOM   547  C CD1 . PHE   A 1 187 ? 129.323 132.106 150.045 1.00 81.24  ? 131 PHE   R CD1 1 
ATOM   548  C CD2 . PHE   A 1 187 ? 131.661 131.672 150.078 1.00 81.24  ? 131 PHE   R CD2 1 
ATOM   549  C CE1 . PHE   A 1 187 ? 129.080 130.854 150.557 1.00 81.24  ? 131 PHE   R CE1 1 
ATOM   550  C CE2 . PHE   A 1 187 ? 131.422 130.417 150.592 1.00 81.24  ? 131 PHE   R CE2 1 
ATOM   551  C CZ  . PHE   A 1 187 ? 130.130 130.007 150.830 1.00 81.24  ? 131 PHE   R CZ  1 
ATOM   552  N N   . ASN   A 1 188 ? 128.345 135.280 148.019 1.00 78.03  ? 132 ASN   R N   1 
ATOM   553  C CA  . ASN   A 1 188 ? 126.891 135.397 147.974 1.00 78.03  ? 132 ASN   R CA  1 
ATOM   554  C C   . ASN   A 1 188 ? 126.376 135.209 146.552 1.00 78.03  ? 132 ASN   R C   1 
ATOM   555  O O   . ASN   A 1 188 ? 125.407 134.470 146.318 1.00 78.03  ? 132 ASN   R O   1 
ATOM   556  C CB  . ASN   A 1 188 ? 126.452 136.748 148.538 1.00 78.03  ? 132 ASN   R CB  1 
ATOM   557  C CG  . ASN   A 1 188 ? 126.006 136.658 149.985 1.00 78.03  ? 132 ASN   R CG  1 
ATOM   558  O OD1 . ASN   A 1 188 ? 126.451 135.784 150.730 1.00 78.03  ? 132 ASN   R OD1 1 
ATOM   559  N ND2 . ASN   A 1 188 ? 125.120 137.560 150.390 1.00 78.03  ? 132 ASN   R ND2 1 
ATOM   560  N N   . ILE   A 1 189 ? 127.025 135.858 145.581 1.00 75.49  ? 133 ILE   R N   1 
ATOM   561  C CA  . ILE   A 1 189 ? 126.600 135.721 144.190 1.00 75.49  ? 133 ILE   R CA  1 
ATOM   562  C C   . ILE   A 1 189 ? 126.630 134.256 143.782 1.00 75.49  ? 133 ILE   R C   1 
ATOM   563  O O   . ILE   A 1 189 ? 125.654 133.718 143.245 1.00 75.49  ? 133 ILE   R O   1 
ATOM   564  C CB  . ILE   A 1 189 ? 127.485 136.573 143.265 1.00 75.49  ? 133 ILE   R CB  1 
ATOM   565  C CG1 . ILE   A 1 189 ? 127.392 138.054 143.635 1.00 75.49  ? 133 ILE   R CG1 1 
ATOM   566  C CG2 . ILE   A 1 189 ? 127.081 136.375 141.815 1.00 75.49  ? 133 ILE   R CG2 1 
ATOM   567  C CD1 . ILE   A 1 189 ? 128.581 138.868 143.173 1.00 75.49  ? 133 ILE   R CD1 1 
ATOM   568  N N   . ASN   A 1 190 ? 127.749 133.582 144.051 1.00 76.27  ? 134 ASN   R N   1 
ATOM   569  C CA  . ASN   A 1 190 ? 127.909 132.214 143.572 1.00 76.27  ? 134 ASN   R CA  1 
ATOM   570  C C   . ASN   A 1 190 ? 126.981 131.256 144.310 1.00 76.27  ? 134 ASN   R C   1 
ATOM   571  O O   . ASN   A 1 190 ? 126.472 130.297 143.725 1.00 76.27  ? 134 ASN   R O   1 
ATOM   572  C CB  . ASN   A 1 190 ? 129.367 131.785 143.712 1.00 76.27  ? 134 ASN   R CB  1 
ATOM   573  C CG  . ASN   A 1 190 ? 130.294 132.606 142.841 1.00 76.27  ? 134 ASN   R CG  1 
ATOM   574  O OD1 . ASN   A 1 190 ? 130.146 132.640 141.620 1.00 76.27  ? 134 ASN   R OD1 1 
ATOM   575  N ND2 . ASN   A 1 190 ? 131.249 133.281 143.464 1.00 76.27  ? 134 ASN   R ND2 1 
ATOM   576  N N   . PHE   A 1 191 ? 126.741 131.505 145.597 1.00 75.99  ? 135 PHE   R N   1 
ATOM   577  C CA  . PHE   A 1 191 ? 125.841 130.660 146.375 1.00 75.99  ? 135 PHE   R CA  1 
ATOM   578  C C   . PHE   A 1 191 ? 124.422 130.735 145.826 1.00 75.99  ? 135 PHE   R C   1 
ATOM   579  O O   . PHE   A 1 191 ? 123.781 129.707 145.555 1.00 75.99  ? 135 PHE   R O   1 
ATOM   580  C CB  . PHE   A 1 191 ? 125.887 131.106 147.839 1.00 75.99  ? 135 PHE   R CB  1 
ATOM   581  C CG  . PHE   A 1 191 ? 125.286 130.129 148.812 1.00 75.99  ? 135 PHE   R CG  1 
ATOM   582  C CD1 . PHE   A 1 191 ? 124.743 128.928 148.393 1.00 75.99  ? 135 PHE   R CD1 1 
ATOM   583  C CD2 . PHE   A 1 191 ? 125.273 130.424 150.163 1.00 75.99  ? 135 PHE   R CD2 1 
ATOM   584  C CE1 . PHE   A 1 191 ? 124.201 128.047 149.304 1.00 75.99  ? 135 PHE   R CE1 1 
ATOM   585  C CE2 . PHE   A 1 191 ? 124.732 129.547 151.074 1.00 75.99  ? 135 PHE   R CE2 1 
ATOM   586  C CZ  . PHE   A 1 191 ? 124.196 128.357 150.645 1.00 75.99  ? 135 PHE   R CZ  1 
ATOM   587  N N   . TYR   A 1 192 ? 123.911 131.957 145.656 1.00 72.35  ? 136 TYR   R N   1 
ATOM   588  C CA  . TYR   A 1 192 ? 122.564 132.106 145.119 1.00 72.35  ? 136 TYR   R CA  1 
ATOM   589  C C   . TYR   A 1 192 ? 122.482 131.556 143.701 1.00 72.35  ? 136 TYR   R C   1 
ATOM   590  O O   . TYR   A 1 192 ? 121.471 130.953 143.318 1.00 72.35  ? 136 TYR   R O   1 
ATOM   591  C CB  . TYR   A 1 192 ? 122.138 133.572 145.159 1.00 72.35  ? 136 TYR   R CB  1 
ATOM   592  C CG  . TYR   A 1 192 ? 121.833 134.087 146.548 1.00 72.35  ? 136 TYR   R CG  1 
ATOM   593  C CD1 . TYR   A 1 192 ? 122.766 133.989 147.571 1.00 72.35  ? 136 TYR   R CD1 1 
ATOM   594  C CD2 . TYR   A 1 192 ? 120.610 134.675 146.836 1.00 72.35  ? 136 TYR   R CD2 1 
ATOM   595  C CE1 . TYR   A 1 192 ? 122.491 134.459 148.837 1.00 72.35  ? 136 TYR   R CE1 1 
ATOM   596  C CE2 . TYR   A 1 192 ? 120.326 135.148 148.100 1.00 72.35  ? 136 TYR   R CE2 1 
ATOM   597  C CZ  . TYR   A 1 192 ? 121.270 135.038 149.096 1.00 72.35  ? 136 TYR   R CZ  1 
ATOM   598  O OH  . TYR   A 1 192 ? 120.991 135.508 150.357 1.00 72.35  ? 136 TYR   R OH  1 
ATOM   599  N N   . ALA   A 1 193 ? 123.536 131.751 142.906 1.00 69.03  ? 137 ALA   R N   1 
ATOM   600  C CA  . ALA   A 1 193 ? 123.545 131.210 141.553 1.00 69.03  ? 137 ALA   R CA  1 
ATOM   601  C C   . ALA   A 1 193 ? 123.472 129.691 141.573 1.00 69.03  ? 137 ALA   R C   1 
ATOM   602  O O   . ALA   A 1 193 ? 122.717 129.087 140.809 1.00 69.03  ? 137 ALA   R O   1 
ATOM   603  C CB  . ALA   A 1 193 ? 124.794 131.681 140.810 1.00 69.03  ? 137 ALA   R CB  1 
ATOM   604  N N   . GLY   A 1 194 ? 124.250 129.052 142.445 1.00 66.91  ? 138 GLY   R N   1 
ATOM   605  C CA  . GLY   A 1 194 ? 124.195 127.604 142.535 1.00 66.91  ? 138 GLY   R CA  1 
ATOM   606  C C   . GLY   A 1 194 ? 122.815 127.109 142.911 1.00 66.91  ? 138 GLY   R C   1 
ATOM   607  O O   . GLY   A 1 194 ? 122.281 126.183 142.296 1.00 66.91  ? 138 GLY   R O   1 
ATOM   608  N N   . ALA   A 1 195 ? 122.208 127.733 143.922 1.00 65.60  ? 139 ALA   R N   1 
ATOM   609  C CA  . ALA   A 1 195 ? 120.870 127.315 144.334 1.00 65.60  ? 139 ALA   R CA  1 
ATOM   610  C C   . ALA   A 1 195 ? 119.873 127.459 143.188 1.00 65.60  ? 139 ALA   R C   1 
ATOM   611  O O   . ALA   A 1 195 ? 119.150 126.511 142.844 1.00 65.60  ? 139 ALA   R O   1 
ATOM   612  C CB  . ALA   A 1 195 ? 120.414 128.132 145.542 1.00 65.60  ? 139 ALA   R CB  1 
ATOM   613  N N   . LEU   A 1 196 ? 119.826 128.643 142.576 1.00 63.83  ? 140 LEU   R N   1 
ATOM   614  C CA  . LEU   A 1 196 ? 118.824 128.892 141.548 1.00 63.83  ? 140 LEU   R CA  1 
ATOM   615  C C   . LEU   A 1 196 ? 119.071 128.047 140.307 1.00 63.83  ? 140 LEU   R C   1 
ATOM   616  O O   . LEU   A 1 196 ? 118.116 127.632 139.644 1.00 63.83  ? 140 LEU   R O   1 
ATOM   617  C CB  . LEU   A 1 196 ? 118.798 130.378 141.199 1.00 63.83  ? 140 LEU   R CB  1 
ATOM   618  C CG  . LEU   A 1 196 ? 118.392 131.290 142.361 1.00 63.83  ? 140 LEU   R CG  1 
ATOM   619  C CD1 . LEU   A 1 196 ? 118.517 132.752 141.972 1.00 63.83  ? 140 LEU   R CD1 1 
ATOM   620  C CD2 . LEU   A 1 196 ? 116.978 130.983 142.831 1.00 63.83  ? 140 LEU   R CD2 1 
ATOM   621  N N   . LEU   A 1 197 ? 120.332 127.761 139.981 1.00 61.91  ? 141 LEU   R N   1 
ATOM   622  C CA  . LEU   A 1 197 ? 120.623 126.908 138.837 1.00 61.91  ? 141 LEU   R CA  1 
ATOM   623  C C   . LEU   A 1 197 ? 120.268 125.456 139.110 1.00 61.91  ? 141 LEU   R C   1 
ATOM   624  O O   . LEU   A 1 197 ? 119.788 124.764 138.207 1.00 61.91  ? 141 LEU   R O   1 
ATOM   625  C CB  . LEU   A 1 197 ? 122.099 127.028 138.455 1.00 61.91  ? 141 LEU   R CB  1 
ATOM   626  C CG  . LEU   A 1 197 ? 122.557 128.355 137.840 1.00 61.91  ? 141 LEU   R CG  1 
ATOM   627  C CD1 . LEU   A 1 197 ? 123.953 128.208 137.268 1.00 61.91  ? 141 LEU   R CD1 1 
ATOM   628  C CD2 . LEU   A 1 197 ? 121.599 128.838 136.765 1.00 61.91  ? 141 LEU   R CD2 1 
ATOM   629  N N   . LEU   A 1 198 ? 120.485 124.973 140.336 1.00 61.08  ? 142 LEU   R N   1 
ATOM   630  C CA  . LEU   A 1 198 ? 120.022 123.639 140.687 1.00 61.08  ? 142 LEU   R CA  1 
ATOM   631  C C   . LEU   A 1 198 ? 118.507 123.534 140.639 1.00 61.08  ? 142 LEU   R C   1 
ATOM   632  O O   . LEU   A 1 198 ? 117.982 122.464 140.313 1.00 61.08  ? 142 LEU   R O   1 
ATOM   633  C CB  . LEU   A 1 198 ? 120.516 123.252 142.081 1.00 61.08  ? 142 LEU   R CB  1 
ATOM   634  C CG  . LEU   A 1 198 ? 122.012 122.985 142.225 1.00 61.08  ? 142 LEU   R CG  1 
ATOM   635  C CD1 . LEU   A 1 198 ? 122.348 122.668 143.668 1.00 61.08  ? 142 LEU   R CD1 1 
ATOM   636  C CD2 . LEU   A 1 198 ? 122.447 121.853 141.316 1.00 61.08  ? 142 LEU   R CD2 1 
ATOM   637  N N   . ALA   A 1 199 ? 117.795 124.613 140.959 1.00 57.74  ? 143 ALA   R N   1 
ATOM   638  C CA  . ALA   A 1 199 ? 116.347 124.622 140.781 1.00 57.74  ? 143 ALA   R CA  1 
ATOM   639  C C   . ALA   A 1 199 ? 115.935 124.660 139.313 1.00 57.74  ? 143 ALA   R C   1 
ATOM   640  O O   . ALA   A 1 199 ? 114.992 123.961 138.917 1.00 57.74  ? 143 ALA   R O   1 
ATOM   641  C CB  . ALA   A 1 199 ? 115.735 125.821 141.509 1.00 57.74  ? 143 ALA   R CB  1 
ATOM   642  N N   . CYS   A 1 200 ? 116.625 125.460 138.498 1.00 56.68  ? 144 CYS   R N   1 
ATOM   643  C CA  . CYS   A 1 200 ? 116.274 125.591 137.089 1.00 56.68  ? 144 CYS   R CA  1 
ATOM   644  C C   . CYS   A 1 200 ? 116.551 124.306 136.319 1.00 56.68  ? 144 CYS   R C   1 
ATOM   645  O O   . CYS   A 1 200 ? 115.800 123.957 135.403 1.00 56.68  ? 144 CYS   R O   1 
ATOM   646  C CB  . CYS   A 1 200 ? 117.042 126.756 136.467 1.00 56.68  ? 144 CYS   R CB  1 
ATOM   647  S SG  . CYS   A 1 200 ? 116.429 128.385 136.948 1.00 56.68  ? 144 CYS   R SG  1 
ATOM   648  N N   . ILE   A 1 201 ? 117.625 123.596 136.666 1.00 55.90  ? 145 ILE   R N   1 
ATOM   649  C CA  . ILE   A 1 201 ? 117.902 122.311 136.026 1.00 55.90  ? 145 ILE   R CA  1 
ATOM   650  C C   . ILE   A 1 201 ? 116.757 121.344 136.290 1.00 55.90  ? 145 ILE   R C   1 
ATOM   651  O O   . ILE   A 1 201 ? 116.297 120.631 135.392 1.00 55.90  ? 145 ILE   R O   1 
ATOM   652  C CB  . ILE   A 1 201 ? 119.241 121.743 136.525 1.00 55.90  ? 145 ILE   R CB  1 
ATOM   653  C CG1 . ILE   A 1 201 ? 120.401 122.568 135.975 1.00 55.90  ? 145 ILE   R CG1 1 
ATOM   654  C CG2 . ILE   A 1 201 ? 119.380 120.287 136.116 1.00 55.90  ? 145 ILE   R CG2 1 
ATOM   655  C CD1 . ILE   A 1 201 ? 121.744 122.196 136.551 1.00 55.90  ? 145 ILE   R CD1 1 
ATOM   656  N N   . SER   A 1 202 ? 116.285 121.305 137.536 1.00 52.28  ? 146 SER   R N   1 
ATOM   657  C CA  . SER   A 1 202 ? 115.174 120.425 137.877 1.00 52.28  ? 146 SER   R CA  1 
ATOM   658  C C   . SER   A 1 202 ? 113.903 120.831 137.145 1.00 52.28  ? 146 SER   R C   1 
ATOM   659  O O   . SER   A 1 202 ? 113.142 119.970 136.692 1.00 52.28  ? 146 SER   R O   1 
ATOM   660  C CB  . SER   A 1 202 ? 114.950 120.431 139.385 1.00 52.28  ? 146 SER   R CB  1 
ATOM   661  O OG  . SER   A 1 202 ? 116.127 120.040 140.066 1.00 52.28  ? 146 SER   R OG  1 
ATOM   662  N N   . PHE   A 1 203 ? 113.647 122.135 137.023 1.00 49.04  ? 147 PHE   R N   1 
ATOM   663  C CA  . PHE   A 1 203 ? 112.473 122.568 136.270 1.00 49.04  ? 147 PHE   R CA  1 
ATOM   664  C C   . PHE   A 1 203 ? 112.572 122.163 134.805 1.00 49.04  ? 147 PHE   R C   1 
ATOM   665  O O   . PHE   A 1 203 ? 111.578 121.751 134.198 1.00 49.04  ? 147 PHE   R O   1 
ATOM   666  C CB  . PHE   A 1 203 ? 112.281 124.077 136.384 1.00 49.04  ? 147 PHE   R CB  1 
ATOM   667  C CG  . PHE   A 1 203 ? 110.939 124.542 135.904 1.00 49.04  ? 147 PHE   R CG  1 
ATOM   668  C CD1 . PHE   A 1 203 ? 109.781 124.110 136.524 1.00 49.04  ? 147 PHE   R CD1 1 
ATOM   669  C CD2 . PHE   A 1 203 ? 110.833 125.398 134.824 1.00 49.04  ? 147 PHE   R CD2 1 
ATOM   670  C CE1 . PHE   A 1 203 ? 108.545 124.528 136.082 1.00 49.04  ? 147 PHE   R CE1 1 
ATOM   671  C CE2 . PHE   A 1 203 ? 109.599 125.821 134.378 1.00 49.04  ? 147 PHE   R CE2 1 
ATOM   672  C CZ  . PHE   A 1 203 ? 108.454 125.385 135.008 1.00 49.04  ? 147 PHE   R CZ  1 
ATOM   673  N N   . ASP   A 1 204 ? 113.757 122.296 134.211 1.00 51.72  ? 148 ASP   R N   1 
ATOM   674  C CA  . ASP   A 1 204 ? 113.939 121.867 132.829 1.00 51.72  ? 148 ASP   R CA  1 
ATOM   675  C C   . ASP   A 1 204 ? 113.697 120.370 132.692 1.00 51.72  ? 148 ASP   R C   1 
ATOM   676  O O   . ASP   A 1 204 ? 113.042 119.916 131.746 1.00 51.72  ? 148 ASP   R O   1 
ATOM   677  C CB  . ASP   A 1 204 ? 115.343 122.231 132.350 1.00 51.72  ? 148 ASP   R CB  1 
ATOM   678  C CG  . ASP   A 1 204 ? 115.549 121.935 130.883 1.00 51.72  ? 148 ASP   R CG  1 
ATOM   679  O OD1 . ASP   A 1 204 ? 114.734 122.401 130.060 1.00 51.72  ? 148 ASP   R OD1 1 
ATOM   680  O OD2 . ASP   A 1 204 ? 116.529 121.238 130.552 1.00 51.72  ? 148 ASP   R OD2 1 
ATOM   681  N N   . ARG   A 1 205 ? 114.221 119.585 133.633 1.00 50.44  ? 149 ARG   R N   1 
ATOM   682  C CA  . ARG   A 1 205 ? 114.000 118.144 133.595 1.00 50.44  ? 149 ARG   R CA  1 
ATOM   683  C C   . ARG   A 1 205 ? 112.515 117.825 133.688 1.00 50.44  ? 149 ARG   R C   1 
ATOM   684  O O   . ARG   A 1 205 ? 112.007 116.954 132.973 1.00 50.44  ? 149 ARG   R O   1 
ATOM   685  C CB  . ARG   A 1 205 ? 114.768 117.463 134.727 1.00 50.44  ? 149 ARG   R CB  1 
ATOM   686  C CG  . ARG   A 1 205 ? 116.248 117.781 134.747 1.00 50.44  ? 149 ARG   R CG  1 
ATOM   687  C CD  . ARG   A 1 205 ? 117.076 116.516 134.738 1.00 50.44  ? 149 ARG   R CD  1 
ATOM   688  N NE  . ARG   A 1 205 ? 118.500 116.799 134.871 1.00 50.44  ? 149 ARG   R NE  1 
ATOM   689  C CZ  . ARG   A 1 205 ? 119.270 116.396 135.873 1.00 50.44  ? 149 ARG   R CZ  1 
ATOM   690  N NH1 . ARG   A 1 205 ? 118.788 115.685 136.880 1.00 50.44  ? 149 ARG   R NH1 1 
ATOM   691  N NH2 . ARG   A 1 205 ? 120.559 116.716 135.867 1.00 50.44  ? 149 ARG   R NH2 1 
ATOM   692  N N   . TYR   A 1 206 ? 111.802 118.520 134.574 1.00 46.14  ? 150 TYR   R N   1 
ATOM   693  C CA  . TYR   A 1 206 ? 110.362 118.323 134.689 1.00 46.14  ? 150 TYR   R CA  1 
ATOM   694  C C   . TYR   A 1 206 ? 109.668 118.626 133.370 1.00 46.14  ? 150 TYR   R C   1 
ATOM   695  O O   . TYR   A 1 206 ? 108.899 117.810 132.853 1.00 46.14  ? 150 TYR   R O   1 
ATOM   696  C CB  . TYR   A 1 206 ? 109.803 119.209 135.801 1.00 46.14  ? 150 TYR   R CB  1 
ATOM   697  C CG  . TYR   A 1 206 ? 108.299 119.311 135.801 1.00 46.14  ? 150 TYR   R CG  1 
ATOM   698  C CD1 . TYR   A 1 206 ? 107.511 118.198 136.033 1.00 46.14  ? 150 TYR   R CD1 1 
ATOM   699  C CD2 . TYR   A 1 206 ? 107.666 120.521 135.572 1.00 46.14  ? 150 TYR   R CD2 1 
ATOM   700  C CE1 . TYR   A 1 206 ? 106.137 118.286 136.037 1.00 46.14  ? 150 TYR   R CE1 1 
ATOM   701  C CE2 . TYR   A 1 206 ? 106.293 120.618 135.572 1.00 46.14  ? 150 TYR   R CE2 1 
ATOM   702  C CZ  . TYR   A 1 206 ? 105.534 119.498 135.806 1.00 46.14  ? 150 TYR   R CZ  1 
ATOM   703  O OH  . TYR   A 1 206 ? 104.163 119.584 135.808 1.00 46.14  ? 150 TYR   R OH  1 
ATOM   704  N N   . LEU   A 1 207 ? 109.939 119.800 132.801 1.00 47.90  ? 151 LEU   R N   1 
ATOM   705  C CA  . LEU   A 1 207 ? 109.287 120.186 131.557 1.00 47.90  ? 151 LEU   R CA  1 
ATOM   706  C C   . LEU   A 1 207 ? 109.607 119.231 130.422 1.00 47.90  ? 151 LEU   R C   1 
ATOM   707  O O   . LEU   A 1 207 ? 108.786 119.072 129.514 1.00 47.90  ? 151 LEU   R O   1 
ATOM   708  C CB  . LEU   A 1 207 ? 109.700 121.603 131.162 1.00 47.90  ? 151 LEU   R CB  1 
ATOM   709  C CG  . LEU   A 1 207 ? 108.968 122.762 131.836 1.00 47.90  ? 151 LEU   R CG  1 
ATOM   710  C CD1 . LEU   A 1 207 ? 109.492 124.075 131.296 1.00 47.90  ? 151 LEU   R CD1 1 
ATOM   711  C CD2 . LEU   A 1 207 ? 107.468 122.663 131.628 1.00 47.90  ? 151 LEU   R CD2 1 
ATOM   712  N N   . ASN   A 1 208 ? 110.776 118.592 130.450 1.00 46.72  ? 152 ASN   R N   1 
ATOM   713  C CA  . ASN   A 1 208 ? 111.179 117.722 129.354 1.00 46.72  ? 152 ASN   R CA  1 
ATOM   714  C C   . ASN   A 1 208 ? 110.747 116.274 129.542 1.00 46.72  ? 152 ASN   R C   1 
ATOM   715  O O   . ASN   A 1 208 ? 110.658 115.537 128.554 1.00 46.72  ? 152 ASN   R O   1 
ATOM   716  C CB  . ASN   A 1 208 ? 112.698 117.774 129.180 1.00 46.72  ? 152 ASN   R CB  1 
ATOM   717  C CG  . ASN   A 1 208 ? 113.142 118.859 128.219 1.00 46.72  ? 152 ASN   R CG  1 
ATOM   718  O OD1 . ASN   A 1 208 ? 112.331 119.442 127.503 1.00 46.72  ? 152 ASN   R OD1 1 
ATOM   719  N ND2 . ASN   A 1 208 ? 114.438 119.136 128.201 1.00 46.72  ? 152 ASN   R ND2 1 
ATOM   720  N N   . ILE   A 1 209 ? 110.471 115.846 130.775 1.00 45.54  ? 153 ILE   R N   1 
ATOM   721  C CA  . ILE   A 1 209 ? 110.158 114.446 131.055 1.00 45.54  ? 153 ILE   R CA  1 
ATOM   722  C C   . ILE   A 1 209 ? 108.704 114.215 131.434 1.00 45.54  ? 153 ILE   R C   1 
ATOM   723  O O   . ILE   A 1 209 ? 108.208 113.093 131.242 1.00 45.54  ? 153 ILE   R O   1 
ATOM   724  C CB  . ILE   A 1 209 ? 111.068 113.878 132.163 1.00 45.54  ? 153 ILE   R CB  1 
ATOM   725  C CG1 . ILE   A 1 209 ? 112.541 114.098 131.825 1.00 45.54  ? 153 ILE   R CG1 1 
ATOM   726  C CG2 . ILE   A 1 209 ? 110.784 112.413 132.359 1.00 45.54  ? 153 ILE   R CG2 1 
ATOM   727  C CD1 . ILE   A 1 209 ? 113.461 113.922 133.008 1.00 45.54  ? 153 ILE   R CD1 1 
ATOM   728  N N   . VAL   A 1 210 ? 108.007 115.214 131.975 1.00 46.88  ? 154 VAL   R N   1 
ATOM   729  C CA  . VAL   A 1 210 ? 106.610 115.087 132.369 1.00 46.88  ? 154 VAL   R CA  1 
ATOM   730  C C   . VAL   A 1 210 ? 105.682 115.605 131.278 1.00 46.88  ? 154 VAL   R C   1 
ATOM   731  O O   . VAL   A 1 210 ? 104.680 114.968 130.944 1.00 46.88  ? 154 VAL   R O   1 
ATOM   732  C CB  . VAL   A 1 210 ? 106.334 115.816 133.701 1.00 46.88  ? 154 VAL   R CB  1 
ATOM   733  C CG1 . VAL   A 1 210 ? 104.843 116.047 133.877 1.00 46.88  ? 154 VAL   R CG1 1 
ATOM   734  C CG2 . VAL   A 1 210 ? 106.897 115.033 134.869 1.00 46.88  ? 154 VAL   R CG2 1 
ATOM   735  N N   . HIS   A 1 211 ? 105.997 116.770 130.721 1.00 50.60  ? 155 HIS   R N   1 
ATOM   736  C CA  . HIS   A 1 211 ? 105.257 117.355 129.607 1.00 50.60  ? 155 HIS   R CA  1 
ATOM   737  C C   . HIS   A 1 211 ? 105.936 117.055 128.280 1.00 50.60  ? 155 HIS   R C   1 
ATOM   738  O O   . HIS   A 1 211 ? 105.815 117.819 127.321 1.00 50.60  ? 155 HIS   R O   1 
ATOM   739  C CB  . HIS   A 1 211 ? 105.112 118.859 129.808 1.00 50.60  ? 155 HIS   R CB  1 
ATOM   740  C CG  . HIS   A 1 211 ? 104.166 119.233 130.905 1.00 50.60  ? 155 HIS   R CG  1 
ATOM   741  N ND1 . HIS   A 1 211 ? 102.803 119.057 130.804 1.00 50.60  ? 155 HIS   R ND1 1 
ATOM   742  C CD2 . HIS   A 1 211 ? 104.387 119.772 132.126 1.00 50.60  ? 155 HIS   R CD2 1 
ATOM   743  C CE1 . HIS   A 1 211 ? 102.225 119.472 131.917 1.00 50.60  ? 155 HIS   R CE1 1 
ATOM   744  N NE2 . HIS   A 1 211 ? 103.164 119.910 132.735 1.00 50.60  ? 155 HIS   R NE2 1 
ATOM   745  N N   . ALA   A 1 212 ? 106.656 115.934 128.205 1.00 52.54  ? 156 ALA   R N   1 
ATOM   746  C CA  . ALA   A 1 212 ? 107.504 115.673 127.047 1.00 52.54  ? 156 ALA   R CA  1 
ATOM   747  C C   . ALA   A 1 212 ? 106.724 115.736 125.744 1.00 52.54  ? 156 ALA   R C   1 
ATOM   748  O O   . ALA   A 1 212 ? 107.248 116.221 124.735 1.00 52.54  ? 156 ALA   R O   1 
ATOM   749  C CB  . ALA   A 1 212 ? 108.173 114.309 127.187 1.00 52.54  ? 156 ALA   R CB  1 
ATOM   750  N N   . THR   A 1 213 ? 105.484 115.258 125.738 1.00 59.35  ? 157 THR   R N   1 
ATOM   751  C CA  . THR   A 1 213 ? 104.676 115.285 124.527 1.00 59.35  ? 157 THR   R CA  1 
ATOM   752  C C   . THR   A 1 213 ? 104.268 116.693 124.122 1.00 59.35  ? 157 THR   R C   1 
ATOM   753  O O   . THR   A 1 213 ? 104.081 116.949 122.927 1.00 59.35  ? 157 THR   R O   1 
ATOM   754  C CB  . THR   A 1 213 ? 103.418 114.432 124.711 1.00 59.35  ? 157 THR   R CB  1 
ATOM   755  O OG1 . THR   A 1 213 ? 103.789 113.061 124.902 1.00 59.35  ? 157 THR   R OG1 1 
ATOM   756  C CG2 . THR   A 1 213 ? 102.512 114.545 123.493 1.00 59.35  ? 157 THR   R CG2 1 
ATOM   757  N N   . GLN   A 1 214 ? 104.133 117.607 125.078 1.00 58.98  ? 158 GLN   R N   1 
ATOM   758  C CA  . GLN   A 1 214 ? 103.695 118.967 124.800 1.00 58.98  ? 158 GLN   R CA  1 
ATOM   759  C C   . GLN   A 1 214 ? 104.845 119.910 124.470 1.00 58.98  ? 158 GLN   R C   1 
ATOM   760  O O   . GLN   A 1 214 ? 104.592 121.051 124.074 1.00 58.98  ? 158 GLN   R O   1 
ATOM   761  C CB  . GLN   A 1 214 ? 102.912 119.518 125.996 1.00 58.98  ? 158 GLN   R CB  1 
ATOM   762  C CG  . GLN   A 1 214 ? 101.847 118.570 126.528 1.00 58.98  ? 158 GLN   R CG  1 
ATOM   763  C CD  . GLN   A 1 214 ? 101.081 119.151 127.699 1.00 58.98  ? 158 GLN   R CD  1 
ATOM   764  O OE1 . GLN   A 1 214 ? 101.271 120.310 128.067 1.00 58.98  ? 158 GLN   R OE1 1 
ATOM   765  N NE2 . GLN   A 1 214 ? 100.209 118.345 128.294 1.00 58.98  ? 158 GLN   R NE2 1 
ATOM   766  N N   . LEU   A 1 215 ? 106.095 119.465 124.618 1.00 58.72  ? 159 LEU   R N   1 
ATOM   767  C CA  . LEU   A 1 215 ? 107.260 120.293 124.326 1.00 58.72  ? 159 LEU   R CA  1 
ATOM   768  C C   . LEU   A 1 215 ? 108.177 119.651 123.293 1.00 58.72  ? 159 LEU   R C   1 
ATOM   769  O O   . LEU   A 1 215 ? 109.370 119.967 123.251 1.00 58.72  ? 159 LEU   R O   1 
ATOM   770  C CB  . LEU   A 1 215 ? 108.050 120.582 125.603 1.00 58.72  ? 159 LEU   R CB  1 
ATOM   771  C CG  . LEU   A 1 215 ? 107.277 121.177 126.776 1.00 58.72  ? 159 LEU   R CG  1 
ATOM   772  C CD1 . LEU   A 1 215 ? 108.236 121.465 127.908 1.00 58.72  ? 159 LEU   R CD1 1 
ATOM   773  C CD2 . LEU   A 1 215 ? 106.537 122.440 126.374 1.00 58.72  ? 159 LEU   R CD2 1 
ATOM   774  N N   . TYR   A 1 216 ? 107.654 118.753 122.462 1.00 83.20  ? 160 TYR   R N   1 
ATOM   775  C CA  . TYR   A 1 216 ? 108.488 118.110 121.457 1.00 83.20  ? 160 TYR   R CA  1 
ATOM   776  C C   . TYR   A 1 216 ? 108.984 119.132 120.444 1.00 83.20  ? 160 TYR   R C   1 
ATOM   777  O O   . TYR   A 1 216 ? 108.238 120.019 120.018 1.00 83.20  ? 160 TYR   R O   1 
ATOM   778  C CB  . TYR   A 1 216 ? 107.714 117.003 120.746 1.00 83.20  ? 160 TYR   R CB  1 
ATOM   779  C CG  . TYR   A 1 216 ? 108.571 116.195 119.797 1.00 83.20  ? 160 TYR   R CG  1 
ATOM   780  C CD1 . TYR   A 1 216 ? 109.720 115.557 120.243 1.00 83.20  ? 160 TYR   R CD1 1 
ATOM   781  C CD2 . TYR   A 1 216 ? 108.238 116.081 118.455 1.00 83.20  ? 160 TYR   R CD2 1 
ATOM   782  C CE1 . TYR   A 1 216 ? 110.510 114.822 119.381 1.00 83.20  ? 160 TYR   R CE1 1 
ATOM   783  C CE2 . TYR   A 1 216 ? 109.021 115.348 117.584 1.00 83.20  ? 160 TYR   R CE2 1 
ATOM   784  C CZ  . TYR   A 1 216 ? 110.156 114.721 118.053 1.00 83.20  ? 160 TYR   R CZ  1 
ATOM   785  O OH  . TYR   A 1 216 ? 110.940 113.989 117.191 1.00 83.20  ? 160 TYR   R OH  1 
ATOM   786  N N   . ARG   A 1 217 ? 110.252 119.006 120.063 1.00 94.70  ? 161 ARG   R N   1 
ATOM   787  C CA  . ARG   A 1 217 ? 110.871 119.874 119.072 1.00 94.70  ? 161 ARG   R CA  1 
ATOM   788  C C   . ARG   A 1 217 ? 111.712 119.013 118.142 1.00 94.70  ? 161 ARG   R C   1 
ATOM   789  O O   . ARG   A 1 217 ? 112.413 118.105 118.601 1.00 94.70  ? 161 ARG   R O   1 
ATOM   790  C CB  . ARG   A 1 217 ? 111.733 120.947 119.744 1.00 94.70  ? 161 ARG   R CB  1 
ATOM   791  C CG  . ARG   A 1 217 ? 111.058 121.635 120.923 1.00 94.70  ? 161 ARG   R CG  1 
ATOM   792  C CD  . ARG   A 1 217 ? 111.497 123.085 121.060 1.00 94.70  ? 161 ARG   R CD  1 
ATOM   793  N NE  . ARG   A 1 217 ? 111.136 123.888 119.898 1.00 94.70  ? 161 ARG   R NE  1 
ATOM   794  C CZ  . ARG   A 1 217 ? 111.328 125.196 119.801 1.00 94.70  ? 161 ARG   R CZ  1 
ATOM   795  N NH1 . ARG   A 1 217 ? 111.881 125.889 120.783 1.00 94.70  ? 161 ARG   R NH1 1 
ATOM   796  N NH2 . ARG   A 1 217 ? 110.957 125.826 118.690 1.00 94.70  ? 161 ARG   R NH2 1 
ATOM   797  N N   . ARG   A 1 218 ? 111.645 119.296 116.839 1.00 103.64 ? 162 ARG   R N   1 
ATOM   798  C CA  . ARG   A 1 218 ? 112.298 118.456 115.832 1.00 103.64 ? 162 ARG   R CA  1 
ATOM   799  C C   . ARG   A 1 218 ? 113.726 118.958 115.627 1.00 103.64 ? 162 ARG   R C   1 
ATOM   800  O O   . ARG   A 1 218 ? 114.151 119.321 114.528 1.00 103.64 ? 162 ARG   R O   1 
ATOM   801  C CB  . ARG   A 1 218 ? 111.493 118.458 114.535 1.00 103.64 ? 162 ARG   R CB  1 
ATOM   802  C CG  . ARG   A 1 218 ? 112.094 117.645 113.384 1.00 103.64 ? 162 ARG   R CG  1 
ATOM   803  C CD  . ARG   A 1 218 ? 112.348 116.193 113.771 1.00 103.64 ? 162 ARG   R CD  1 
ATOM   804  N NE  . ARG   A 1 218 ? 113.049 115.462 112.720 1.00 103.64 ? 162 ARG   R NE  1 
ATOM   805  C CZ  . ARG   A 1 218 ? 114.329 115.112 112.758 1.00 103.64 ? 162 ARG   R CZ  1 
ATOM   806  N NH1 . ARG   A 1 218 ? 115.106 115.425 113.784 1.00 103.64 ? 162 ARG   R NH1 1 
ATOM   807  N NH2 . ARG   A 1 218 ? 114.845 114.433 111.738 1.00 103.64 ? 162 ARG   R NH2 1 
ATOM   808  N N   . GLY   A 1 219 ? 114.473 118.993 116.728 1.00 106.97 ? 163 GLY   R N   1 
ATOM   809  C CA  . GLY   A 1 219 ? 115.881 119.306 116.693 1.00 106.97 ? 163 GLY   R CA  1 
ATOM   810  C C   . GLY   A 1 219 ? 116.275 120.772 116.569 1.00 106.97 ? 163 GLY   R C   1 
ATOM   811  O O   . GLY   A 1 219 ? 117.334 121.076 116.009 1.00 106.97 ? 163 GLY   R O   1 
ATOM   812  N N   . PRO   A 1 220 ? 115.468 121.710 117.067 1.00 100.35 ? 164 PRO   R N   1 
ATOM   813  C CA  . PRO   A 1 220 ? 115.973 123.070 117.244 1.00 100.35 ? 164 PRO   R CA  1 
ATOM   814  C C   . PRO   A 1 220 ? 116.500 123.265 118.654 1.00 100.35 ? 164 PRO   R C   1 
ATOM   815  O O   . PRO   A 1 220 ? 115.880 122.801 119.623 1.00 100.35 ? 164 PRO   R O   1 
ATOM   816  C CB  . PRO   A 1 220 ? 114.738 123.940 116.987 1.00 100.35 ? 164 PRO   R CB  1 
ATOM   817  C CG  . PRO   A 1 220 ? 113.593 123.096 117.425 1.00 100.35 ? 164 PRO   R CG  1 
ATOM   818  C CD  . PRO   A 1 220 ? 114.042 121.646 117.437 1.00 100.35 ? 164 PRO   R CD  1 
ATOM   819  N N   . PRO   A 1 221 ? 117.632 123.947 118.819 1.00 92.05  ? 165 PRO   R N   1 
ATOM   820  C CA  . PRO   A 1 221 ? 118.125 124.214 120.175 1.00 92.05  ? 165 PRO   R CA  1 
ATOM   821  C C   . PRO   A 1 221 ? 117.412 125.388 120.821 1.00 92.05  ? 165 PRO   R C   1 
ATOM   822  O O   . PRO   A 1 221 ? 117.646 126.542 120.450 1.00 92.05  ? 165 PRO   R O   1 
ATOM   823  C CB  . PRO   A 1 221 ? 119.611 124.506 119.950 1.00 92.05  ? 165 PRO   R CB  1 
ATOM   824  C CG  . PRO   A 1 221 ? 119.671 125.095 118.575 1.00 92.05  ? 165 PRO   R CG  1 
ATOM   825  C CD  . PRO   A 1 221 ? 118.493 124.560 117.791 1.00 92.05  ? 165 PRO   R CD  1 
ATOM   826  N N   . ALA   A 1 222 ? 116.543 125.111 121.788 1.00 85.94  ? 166 ALA   R N   1 
ATOM   827  C CA  . ALA   A 1 222 ? 115.808 126.164 122.483 1.00 85.94  ? 166 ALA   R CA  1 
ATOM   828  C C   . ALA   A 1 222 ? 116.793 126.984 123.303 1.00 85.94  ? 166 ALA   R C   1 
ATOM   829  O O   . ALA   A 1 222 ? 117.419 126.476 124.236 1.00 85.94  ? 166 ALA   R O   1 
ATOM   830  C CB  . ALA   A 1 222 ? 114.722 125.563 123.367 1.00 85.94  ? 166 ALA   R CB  1 
ATOM   831  N N   . ARG   A 1 223 ? 116.945 128.258 122.954 1.00 75.49  ? 167 ARG   R N   1 
ATOM   832  C CA  . ARG   A 1 223 ? 117.867 129.110 123.683 1.00 75.49  ? 167 ARG   R CA  1 
ATOM   833  C C   . ARG   A 1 223 ? 117.294 129.450 125.056 1.00 75.49  ? 167 ARG   R C   1 
ATOM   834  O O   . ARG   A 1 223 ? 116.096 129.698 125.217 1.00 75.49  ? 167 ARG   R O   1 
ATOM   835  C CB  . ARG   A 1 223 ? 118.157 130.385 122.890 1.00 75.49  ? 167 ARG   R CB  1 
ATOM   836  C CG  . ARG   A 1 223 ? 118.740 130.146 121.498 1.00 75.49  ? 167 ARG   R CG  1 
ATOM   837  C CD  . ARG   A 1 223 ? 120.068 129.403 121.537 1.00 75.49  ? 167 ARG   R CD  1 
ATOM   838  N NE  . ARG   A 1 223 ? 121.123 130.212 122.137 1.00 75.49  ? 167 ARG   R NE  1 
ATOM   839  C CZ  . ARG   A 1 223 ? 121.644 130.014 123.342 1.00 75.49  ? 167 ARG   R CZ  1 
ATOM   840  N NH1 . ARG   A 1 223 ? 121.259 129.008 124.112 1.00 75.49  ? 167 ARG   R NH1 1 
ATOM   841  N NH2 . ARG   A 1 223 ? 122.580 130.848 123.787 1.00 75.49  ? 167 ARG   R NH2 1 
ATOM   842  N N   . VAL   A 1 224 ? 118.173 129.456 126.057 1.00 67.59  ? 168 VAL   R N   1 
ATOM   843  C CA  . VAL   A 1 224 ? 117.766 129.648 127.444 1.00 67.59  ? 168 VAL   R CA  1 
ATOM   844  C C   . VAL   A 1 224 ? 118.601 130.746 128.089 1.00 67.59  ? 168 VAL   R C   1 
ATOM   845  O O   . VAL   A 1 224 ? 118.696 130.824 129.318 1.00 67.59  ? 168 VAL   R O   1 
ATOM   846  C CB  . VAL   A 1 224 ? 117.887 128.332 128.232 1.00 67.59  ? 168 VAL   R CB  1 
ATOM   847  C CG1 . VAL   A 1 224 ? 119.347 128.021 128.523 1.00 67.59  ? 168 VAL   R CG1 1 
ATOM   848  C CG2 . VAL   A 1 224 ? 117.078 128.402 129.517 1.00 67.59  ? 168 VAL   R CG2 1 
ATOM   849  N N   . THR   A 1 225 ? 119.215 131.600 127.269 1.00 68.53  ? 169 THR   R N   1 
ATOM   850  C CA  . THR   A 1 225 ? 120.091 132.633 127.812 1.00 68.53  ? 169 THR   R CA  1 
ATOM   851  C C   . THR   A 1 225 ? 119.331 133.607 128.701 1.00 68.53  ? 169 THR   R C   1 
ATOM   852  O O   . THR   A 1 225 ? 119.905 134.168 129.644 1.00 68.53  ? 169 THR   R O   1 
ATOM   853  C CB  . THR   A 1 225 ? 120.777 133.385 126.674 1.00 68.53  ? 169 THR   R CB  1 
ATOM   854  O OG1 . THR   A 1 225 ? 121.769 132.544 126.072 1.00 68.53  ? 169 THR   R OG1 1 
ATOM   855  C CG2 . THR   A 1 225 ? 121.438 134.651 127.191 1.00 68.53  ? 169 THR   R CG2 1 
ATOM   856  N N   . LEU   A 1 226 ? 118.046 133.824 128.420 1.00 66.80  ? 170 LEU   R N   1 
ATOM   857  C CA  . LEU   A 1 226 ? 117.265 134.784 129.191 1.00 66.80  ? 170 LEU   R CA  1 
ATOM   858  C C   . LEU   A 1 226 ? 117.238 134.404 130.667 1.00 66.80  ? 170 LEU   R C   1 
ATOM   859  O O   . LEU   A 1 226 ? 117.495 135.238 131.544 1.00 66.80  ? 170 LEU   R O   1 
ATOM   860  C CB  . LEU   A 1 226 ? 115.846 134.865 128.624 1.00 66.80  ? 170 LEU   R CB  1 
ATOM   861  C CG  . LEU   A 1 226 ? 114.841 135.741 129.376 1.00 66.80  ? 170 LEU   R CG  1 
ATOM   862  C CD1 . LEU   A 1 226 ? 115.060 137.208 129.048 1.00 66.80  ? 170 LEU   R CD1 1 
ATOM   863  C CD2 . LEU   A 1 226 ? 113.417 135.322 129.043 1.00 66.80  ? 170 LEU   R CD2 1 
ATOM   864  N N   . THR   A 1 227 ? 116.931 133.139 130.959 1.00 65.90  ? 171 THR   R N   1 
ATOM   865  C CA  . THR   A 1 227 ? 116.839 132.709 132.351 1.00 65.90  ? 171 THR   R CA  1 
ATOM   866  C C   . THR   A 1 227 ? 118.194 132.791 133.038 1.00 65.90  ? 171 THR   R C   1 
ATOM   867  O O   . THR   A 1 227 ? 118.283 133.171 134.210 1.00 65.90  ? 171 THR   R O   1 
ATOM   868  C CB  . THR   A 1 227 ? 116.286 131.285 132.441 1.00 65.90  ? 171 THR   R CB  1 
ATOM   869  O OG1 . THR   A 1 227 ? 117.348 130.344 132.243 1.00 65.90  ? 171 THR   R OG1 1 
ATOM   870  C CG2 . THR   A 1 227 ? 115.192 131.049 131.405 1.00 65.90  ? 171 THR   R CG2 1 
ATOM   871  N N   . CYS   A 1 228 ? 119.262 132.433 132.327 1.00 66.47  ? 172 CYS   R N   1 
ATOM   872  C CA  . CYS   A 1 228 ? 120.598 132.496 132.907 1.00 66.47  ? 172 CYS   R CA  1 
ATOM   873  C C   . CYS   A 1 228 ? 120.958 133.927 133.289 1.00 66.47  ? 172 CYS   R C   1 
ATOM   874  O O   . CYS   A 1 228 ? 121.439 134.193 134.399 1.00 66.47  ? 172 CYS   R O   1 
ATOM   875  C CB  . CYS   A 1 228 ? 121.613 131.927 131.916 1.00 66.47  ? 172 CYS   R CB  1 
ATOM   876  S SG  . CYS   A 1 228 ? 121.583 130.128 131.796 1.00 66.47  ? 172 CYS   R SG  1 
ATOM   877  N N   . LEU   A 1 229 ? 120.733 134.870 132.370 1.00 67.49  ? 173 LEU   R N   1 
ATOM   878  C CA  . LEU   A 1 229 ? 121.039 136.264 132.668 1.00 67.49  ? 173 LEU   R CA  1 
ATOM   879  C C   . LEU   A 1 229 ? 120.177 136.781 133.810 1.00 67.49  ? 173 LEU   R C   1 
ATOM   880  O O   . LEU   A 1 229 ? 120.664 137.513 134.681 1.00 67.49  ? 173 LEU   R O   1 
ATOM   881  C CB  . LEU   A 1 229 ? 120.846 137.128 131.421 1.00 67.49  ? 173 LEU   R CB  1 
ATOM   882  C CG  . LEU   A 1 229 ? 121.835 136.946 130.264 1.00 67.49  ? 173 LEU   R CG  1 
ATOM   883  C CD1 . LEU   A 1 229 ? 121.937 138.238 129.468 1.00 67.49  ? 173 LEU   R CD1 1 
ATOM   884  C CD2 . LEU   A 1 229 ? 123.215 136.506 130.741 1.00 67.49  ? 173 LEU   R CD2 1 
ATOM   885  N N   . ALA   A 1 230 ? 118.893 136.415 133.826 1.00 66.78  ? 174 ALA   R N   1 
ATOM   886  C CA  . ALA   A 1 230 ? 118.022 136.848 134.913 1.00 66.78  ? 174 ALA   R CA  1 
ATOM   887  C C   . ALA   A 1 230 ? 118.523 136.321 136.250 1.00 66.78  ? 174 ALA   R C   1 
ATOM   888  O O   . ALA   A 1 230 ? 118.560 137.052 137.246 1.00 66.78  ? 174 ALA   R O   1 
ATOM   889  C CB  . ALA   A 1 230 ? 116.590 136.382 134.653 1.00 66.78  ? 174 ALA   R CB  1 
ATOM   890  N N   . VAL   A 1 231 ? 118.927 135.050 136.287 1.00 66.53  ? 175 VAL   R N   1 
ATOM   891  C CA  . VAL   A 1 231 ? 119.424 134.452 137.524 1.00 66.53  ? 175 VAL   R CA  1 
ATOM   892  C C   . VAL   A 1 231 ? 120.669 135.189 137.998 1.00 66.53  ? 175 VAL   R C   1 
ATOM   893  O O   . VAL   A 1 231 ? 120.798 135.542 139.175 1.00 66.53  ? 175 VAL   R O   1 
ATOM   894  C CB  . VAL   A 1 231 ? 119.708 132.954 137.320 1.00 66.53  ? 175 VAL   R CB  1 
ATOM   895  C CG1 . VAL   A 1 231 ? 120.669 132.438 138.381 1.00 66.53  ? 175 VAL   R CG1 1 
ATOM   896  C CG2 . VAL   A 1 231 ? 118.412 132.165 137.345 1.00 66.53  ? 175 VAL   R CG2 1 
ATOM   897  N N   . TRP   A 1 232 ? 121.609 135.428 137.082 1.00 68.11  ? 176 TRP   R N   1 
ATOM   898  C CA  . TRP   A 1 232 ? 122.858 136.070 137.480 1.00 68.11  ? 176 TRP   R CA  1 
ATOM   899  C C   . TRP   A 1 232 ? 122.619 137.494 137.966 1.00 68.11  ? 176 TRP   R C   1 
ATOM   900  O O   . TRP   A 1 232 ? 123.200 137.923 138.972 1.00 68.11  ? 176 TRP   R O   1 
ATOM   901  C CB  . TRP   A 1 232 ? 123.847 136.051 136.317 1.00 68.11  ? 176 TRP   R CB  1 
ATOM   902  C CG  . TRP   A 1 232 ? 124.615 134.774 136.232 1.00 68.11  ? 176 TRP   R CG  1 
ATOM   903  C CD1 . TRP   A 1 232 ? 124.445 133.779 135.319 1.00 68.11  ? 176 TRP   R CD1 1 
ATOM   904  C CD2 . TRP   A 1 232 ? 125.670 134.347 137.100 1.00 68.11  ? 176 TRP   R CD2 1 
ATOM   905  N NE1 . TRP   A 1 232 ? 125.330 132.759 135.561 1.00 68.11  ? 176 TRP   R NE1 1 
ATOM   906  C CE2 . TRP   A 1 232 ? 126.094 133.084 136.650 1.00 68.11  ? 176 TRP   R CE2 1 
ATOM   907  C CE3 . TRP   A 1 232 ? 126.298 134.911 138.213 1.00 68.11  ? 176 TRP   R CE3 1 
ATOM   908  C CZ2 . TRP   A 1 232 ? 127.118 132.376 137.272 1.00 68.11  ? 176 TRP   R CZ2 1 
ATOM   909  C CZ3 . TRP   A 1 232 ? 127.314 134.206 138.829 1.00 68.11  ? 176 TRP   R CZ3 1 
ATOM   910  C CH2 . TRP   A 1 232 ? 127.713 132.953 138.358 1.00 68.11  ? 176 TRP   R CH2 1 
ATOM   911  N N   . GLY   A 1 233 ? 121.763 138.242 137.274 1.00 70.80  ? 177 GLY   R N   1 
ATOM   912  C CA  . GLY   A 1 233 ? 121.453 139.596 137.686 1.00 70.80  ? 177 GLY   R CA  1 
ATOM   913  C C   . GLY   A 1 233 ? 120.774 139.646 139.039 1.00 70.80  ? 177 GLY   R C   1 
ATOM   914  O O   . GLY   A 1 233 ? 121.122 140.471 139.893 1.00 70.80  ? 177 GLY   R O   1 
ATOM   915  N N   . LEU   A 1 234 ? 119.799 138.759 139.247 1.00 71.29  ? 178 LEU   R N   1 
ATOM   916  C CA  . LEU   A 1 234 ? 119.121 138.703 140.535 1.00 71.29  ? 178 LEU   R CA  1 
ATOM   917  C C   . LEU   A 1 234 ? 120.098 138.338 141.643 1.00 71.29  ? 178 LEU   R C   1 
ATOM   918  O O   . LEU   A 1 234 ? 120.021 138.876 142.751 1.00 71.29  ? 178 LEU   R O   1 
ATOM   919  C CB  . LEU   A 1 234 ? 117.968 137.700 140.470 1.00 71.29  ? 178 LEU   R CB  1 
ATOM   920  C CG  . LEU   A 1 234 ? 117.166 137.490 141.755 1.00 71.29  ? 178 LEU   R CG  1 
ATOM   921  C CD1 . LEU   A 1 234 ? 116.102 138.564 141.894 1.00 71.29  ? 178 LEU   R CD1 1 
ATOM   922  C CD2 . LEU   A 1 234 ? 116.535 136.109 141.771 1.00 71.29  ? 178 LEU   R CD2 1 
ATOM   923  N N   . CYS   A 1 235 ? 121.028 137.425 141.362 1.00 72.20  ? 179 CYS   R N   1 
ATOM   924  C CA  . CYS   A 1 235 ? 122.034 137.055 142.352 1.00 72.20  ? 179 CYS   R CA  1 
ATOM   925  C C   . CYS   A 1 235 ? 122.908 138.250 142.711 1.00 72.20  ? 179 CYS   R C   1 
ATOM   926  O O   . CYS   A 1 235 ? 123.207 138.491 143.886 1.00 72.20  ? 179 CYS   R O   1 
ATOM   927  C CB  . CYS   A 1 235 ? 122.886 135.909 141.812 1.00 72.20  ? 179 CYS   R CB  1 
ATOM   928  S SG  . CYS   A 1 235 ? 122.022 134.335 141.710 1.00 72.20  ? 179 CYS   R SG  1 
ATOM   929  N N   . LEU   A 1 236 ? 123.339 139.007 141.702 1.00 73.78  ? 180 LEU   R N   1 
ATOM   930  C CA  . LEU   A 1 236 ? 124.151 140.192 141.960 1.00 73.78  ? 180 LEU   R CA  1 
ATOM   931  C C   . LEU   A 1 236 ? 123.392 141.194 142.823 1.00 73.78  ? 180 LEU   R C   1 
ATOM   932  O O   . LEU   A 1 236 ? 123.937 141.754 143.783 1.00 73.78  ? 180 LEU   R O   1 
ATOM   933  C CB  . LEU   A 1 236 ? 124.571 140.835 140.636 1.00 73.78  ? 180 LEU   R CB  1 
ATOM   934  C CG  . LEU   A 1 236 ? 126.022 140.625 140.202 1.00 73.78  ? 180 LEU   R CG  1 
ATOM   935  C CD1 . LEU   A 1 236 ? 126.219 141.103 138.774 1.00 73.78  ? 180 LEU   R CD1 1 
ATOM   936  C CD2 . LEU   A 1 236 ? 126.974 141.347 141.142 1.00 73.78  ? 180 LEU   R CD2 1 
ATOM   937  N N   . LEU   A 1 237 ? 122.121 141.425 142.493 1.00 75.13  ? 181 LEU   R N   1 
ATOM   938  C CA  . LEU   A 1 237 ? 121.330 142.386 143.256 1.00 75.13  ? 181 LEU   R CA  1 
ATOM   939  C C   . LEU   A 1 237 ? 121.095 141.894 144.680 1.00 75.13  ? 181 LEU   R C   1 
ATOM   940  O O   . LEU   A 1 237 ? 121.032 142.693 145.620 1.00 75.13  ? 181 LEU   R O   1 
ATOM   941  C CB  . LEU   A 1 237 ? 120.004 142.657 142.545 1.00 75.13  ? 181 LEU   R CB  1 
ATOM   942  C CG  . LEU   A 1 237 ? 120.077 143.271 141.141 1.00 75.13  ? 181 LEU   R CG  1 
ATOM   943  C CD1 . LEU   A 1 237 ? 118.887 144.191 140.908 1.00 75.13  ? 181 LEU   R CD1 1 
ATOM   944  C CD2 . LEU   A 1 237 ? 121.384 144.022 140.895 1.00 75.13  ? 181 LEU   R CD2 1 
ATOM   945  N N   . PHE   A 1 238 ? 120.952 140.579 144.857 1.00 74.89  ? 182 PHE   R N   1 
ATOM   946  C CA  . PHE   A 1 238 ? 120.827 140.021 146.200 1.00 74.89  ? 182 PHE   R CA  1 
ATOM   947  C C   . PHE   A 1 238 ? 122.111 140.213 146.994 1.00 74.89  ? 182 PHE   R C   1 
ATOM   948  O O   . PHE   A 1 238 ? 122.074 140.496 148.197 1.00 74.89  ? 182 PHE   R O   1 
ATOM   949  C CB  . PHE   A 1 238 ? 120.478 138.533 146.118 1.00 74.89  ? 182 PHE   R CB  1 
ATOM   950  C CG  . PHE   A 1 238 ? 119.006 138.242 146.215 1.00 74.89  ? 182 PHE   R CG  1 
ATOM   951  C CD1 . PHE   A 1 238 ? 118.253 138.720 147.275 1.00 74.89  ? 182 PHE   R CD1 1 
ATOM   952  C CD2 . PHE   A 1 238 ? 118.376 137.482 145.245 1.00 74.89  ? 182 PHE   R CD2 1 
ATOM   953  C CE1 . PHE   A 1 238 ? 116.902 138.450 147.360 1.00 74.89  ? 182 PHE   R CE1 1 
ATOM   954  C CE2 . PHE   A 1 238 ? 117.025 137.208 145.326 1.00 74.89  ? 182 PHE   R CE2 1 
ATOM   955  C CZ  . PHE   A 1 238 ? 116.288 137.692 146.385 1.00 74.89  ? 182 PHE   R CZ  1 
ATOM   956  N N   . ALA   A 1 239 ? 123.261 140.049 146.337 1.00 77.11  ? 183 ALA   R N   1 
ATOM   957  C CA  . ALA   A 1 239 ? 124.537 140.130 147.039 1.00 77.11  ? 183 ALA   R CA  1 
ATOM   958  C C   . ALA   A 1 239 ? 124.975 141.571 147.266 1.00 77.11  ? 183 ALA   R C   1 
ATOM   959  O O   . ALA   A 1 239 ? 125.923 141.812 148.022 1.00 77.11  ? 183 ALA   R O   1 
ATOM   960  C CB  . ALA   A 1 239 ? 125.609 139.373 146.260 1.00 77.11  ? 183 ALA   R CB  1 
ATOM   961  N N   . LEU   A 1 240 ? 124.315 142.531 146.615 1.00 78.70  ? 184 LEU   R N   1 
ATOM   962  C CA  . LEU   A 1 240 ? 124.623 143.953 146.777 1.00 78.70  ? 184 LEU   R CA  1 
ATOM   963  C C   . LEU   A 1 240 ? 125.060 144.325 148.193 1.00 78.70  ? 184 LEU   R C   1 
ATOM   964  O O   . LEU   A 1 240 ? 126.114 144.950 148.360 1.00 78.70  ? 184 LEU   R O   1 
ATOM   965  C CB  . LEU   A 1 240 ? 123.407 144.801 146.397 1.00 78.70  ? 184 LEU   R CB  1 
ATOM   966  C CG  . LEU   A 1 240 ? 123.459 145.527 145.052 1.00 78.70  ? 184 LEU   R CG  1 
ATOM   967  C CD1 . LEU   A 1 240 ? 122.101 146.113 144.712 1.00 78.70  ? 184 LEU   R CD1 1 
ATOM   968  C CD2 . LEU   A 1 240 ? 124.511 146.620 145.078 1.00 78.70  ? 184 LEU   R CD2 1 
ATOM   969  N N   . PRO   A 1 241 ? 124.290 143.973 149.237 1.00 80.98  ? 185 PRO   R N   1 
ATOM   970  C CA  . PRO   A 1 241 ? 124.624 144.448 150.589 1.00 80.98  ? 185 PRO   R CA  1 
ATOM   971  C C   . PRO   A 1 241 ? 126.048 144.139 151.029 1.00 80.98  ? 185 PRO   R C   1 
ATOM   972  O O   . PRO   A 1 241 ? 126.611 144.863 151.857 1.00 80.98  ? 185 PRO   R O   1 
ATOM   973  C CB  . PRO   A 1 241 ? 123.608 143.719 151.484 1.00 80.98  ? 185 PRO   R CB  1 
ATOM   974  C CG  . PRO   A 1 241 ? 122.784 142.848 150.574 1.00 80.98  ? 185 PRO   R CG  1 
ATOM   975  C CD  . PRO   A 1 241 ? 122.946 143.380 149.199 1.00 80.98  ? 185 PRO   R CD  1 
ATOM   976  N N   . ASP   A 1 242 ? 126.629 143.058 150.506 1.00 82.85  ? 186 ASP   R N   1 
ATOM   977  C CA  . ASP   A 1 242 ? 127.994 142.697 150.875 1.00 82.85  ? 186 ASP   R CA  1 
ATOM   978  C C   . ASP   A 1 242 ? 128.980 143.779 150.451 1.00 82.85  ? 186 ASP   R C   1 
ATOM   979  O O   . ASP   A 1 242 ? 129.913 144.114 151.189 1.00 82.85  ? 186 ASP   R O   1 
ATOM   980  C CB  . ASP   A 1 242 ? 128.363 141.353 150.249 1.00 82.85  ? 186 ASP   R CB  1 
ATOM   981  C CG  . ASP   A 1 242 ? 127.467 140.229 150.719 1.00 82.85  ? 186 ASP   R CG  1 
ATOM   982  O OD1 . ASP   A 1 242 ? 126.471 140.515 151.415 1.00 82.85  ? 186 ASP   R OD1 1 
ATOM   983  O OD2 . ASP   A 1 242 ? 127.760 139.059 150.396 1.00 82.85  ? 186 ASP   R OD2 1 
ATOM   984  N N   . PHE   A 1 243 ? 128.787 144.341 149.257 1.00 80.72  ? 187 PHE   R N   1 
ATOM   985  C CA  . PHE   A 1 243 ? 129.677 145.391 148.778 1.00 80.72  ? 187 PHE   R CA  1 
ATOM   986  C C   . PHE   A 1 243 ? 129.718 146.590 149.713 1.00 80.72  ? 187 PHE   R C   1 
ATOM   987  O O   . PHE   A 1 243 ? 130.710 147.327 149.717 1.00 80.72  ? 187 PHE   R O   1 
ATOM   988  C CB  . PHE   A 1 243 ? 129.242 145.854 147.387 1.00 80.72  ? 187 PHE   R CB  1 
ATOM   989  C CG  . PHE   A 1 243 ? 129.576 144.886 146.293 1.00 80.72  ? 187 PHE   R CG  1 
ATOM   990  C CD1 . PHE   A 1 243 ? 130.891 144.654 145.937 1.00 80.72  ? 187 PHE   R CD1 1 
ATOM   991  C CD2 . PHE   A 1 243 ? 128.576 144.210 145.619 1.00 80.72  ? 187 PHE   R CD2 1 
ATOM   992  C CE1 . PHE   A 1 243 ? 131.204 143.768 144.929 1.00 80.72  ? 187 PHE   R CE1 1 
ATOM   993  C CE2 . PHE   A 1 243 ? 128.883 143.321 144.610 1.00 80.72  ? 187 PHE   R CE2 1 
ATOM   994  C CZ  . PHE   A 1 243 ? 130.199 143.101 144.264 1.00 80.72  ? 187 PHE   R CZ  1 
ATOM   995  N N   . ILE   A 1 244 ? 128.668 146.806 150.500 1.00 84.41  ? 188 ILE   R N   1 
ATOM   996  C CA  . ILE   A 1 244 ? 128.515 148.019 151.288 1.00 84.41  ? 188 ILE   R CA  1 
ATOM   997  C C   . ILE   A 1 244 ? 128.839 147.786 152.759 1.00 84.41  ? 188 ILE   R C   1 
ATOM   998  O O   . ILE   A 1 244 ? 129.532 148.597 153.377 1.00 84.41  ? 188 ILE   R O   1 
ATOM   999  C CB  . ILE   A 1 244 ? 127.090 148.593 151.129 1.00 84.41  ? 188 ILE   R CB  1 
ATOM   1000 C CG1 . ILE   A 1 244 ? 126.757 148.841 149.655 1.00 84.41  ? 188 ILE   R CG1 1 
ATOM   1001 C CG2 . ILE   A 1 244 ? 126.946 149.881 151.919 1.00 84.41  ? 188 ILE   R CG2 1 
ATOM   1002 C CD1 . ILE   A 1 244 ? 125.367 148.387 149.265 1.00 84.41  ? 188 ILE   R CD1 1 
ATOM   1003 N N   . PHE   A 1 245 ? 128.352 146.689 153.335 1.00 85.04  ? 189 PHE   R N   1 
ATOM   1004 C CA  . PHE   A 1 245 ? 128.283 146.575 154.787 1.00 85.04  ? 189 PHE   R CA  1 
ATOM   1005 C C   . PHE   A 1 245 ? 129.330 145.638 155.377 1.00 85.04  ? 189 PHE   R C   1 
ATOM   1006 O O   . PHE   A 1 245 ? 129.964 145.973 156.382 1.00 85.04  ? 189 PHE   R O   1 
ATOM   1007 C CB  . PHE   A 1 245 ? 126.880 146.124 155.181 1.00 85.04  ? 189 PHE   R CB  1 
ATOM   1008 C CG  . PHE   A 1 245 ? 125.805 147.044 154.689 1.00 85.04  ? 189 PHE   R CG  1 
ATOM   1009 C CD1 . PHE   A 1 245 ? 125.665 148.310 155.229 1.00 85.04  ? 189 PHE   R CD1 1 
ATOM   1010 C CD2 . PHE   A 1 245 ? 124.962 146.662 153.663 1.00 85.04  ? 189 PHE   R CD2 1 
ATOM   1011 C CE1 . PHE   A 1 245 ? 124.685 149.168 154.773 1.00 85.04  ? 189 PHE   R CE1 1 
ATOM   1012 C CE2 . PHE   A 1 245 ? 123.978 147.517 153.202 1.00 85.04  ? 189 PHE   R CE2 1 
ATOM   1013 C CZ  . PHE   A 1 245 ? 123.841 148.771 153.758 1.00 85.04  ? 189 PHE   R CZ  1 
ATOM   1014 N N   . LEU   A 1 246 ? 129.508 144.463 154.778 1.00 87.47  ? 190 LEU   R N   1 
ATOM   1015 C CA  . LEU   A 1 246 ? 130.449 143.481 155.305 1.00 87.47  ? 190 LEU   R CA  1 
ATOM   1016 C C   . LEU   A 1 246 ? 131.803 144.123 155.587 1.00 87.47  ? 190 LEU   R C   1 
ATOM   1017 O O   . LEU   A 1 246 ? 132.368 144.795 154.719 1.00 87.47  ? 190 LEU   R O   1 
ATOM   1018 C CB  . LEU   A 1 246 ? 130.605 142.321 154.320 1.00 87.47  ? 190 LEU   R CB  1 
ATOM   1019 C CG  . LEU   A 1 246 ? 130.773 140.925 154.918 1.00 87.47  ? 190 LEU   R CG  1 
ATOM   1020 C CD1 . LEU   A 1 246 ? 129.572 140.556 155.769 1.00 87.47  ? 190 LEU   R CD1 1 
ATOM   1021 C CD2 . LEU   A 1 246 ? 130.977 139.903 153.817 1.00 87.47  ? 190 LEU   R CD2 1 
ATOM   1022 N N   . SER   A 1 247 ? 132.326 143.929 156.792 1.00 90.67  ? 191 SER   R N   1 
ATOM   1023 C CA  . SER   A 1 247 ? 133.614 144.498 157.180 1.00 90.67  ? 191 SER   R CA  1 
ATOM   1024 C C   . SER   A 1 247 ? 134.255 143.562 158.201 1.00 90.67  ? 191 SER   R C   1 
ATOM   1025 O O   . SER   A 1 247 ? 133.814 142.421 158.374 1.00 90.67  ? 191 SER   R O   1 
ATOM   1026 C CB  . SER   A 1 247 ? 133.428 145.929 157.712 1.00 90.67  ? 191 SER   R CB  1 
ATOM   1027 O OG  . SER   A 1 247 ? 134.632 146.426 158.269 1.00 90.67  ? 191 SER   R OG  1 
ATOM   1028 N N   . ALA   A 1 248 ? 135.295 144.041 158.881 1.00 95.61  ? 192 ALA   R N   1 
ATOM   1029 C CA  . ALA   A 1 248 ? 136.010 143.271 159.899 1.00 95.61  ? 192 ALA   R CA  1 
ATOM   1030 C C   . ALA   A 1 248 ? 135.841 143.975 161.242 1.00 95.61  ? 192 ALA   R C   1 
ATOM   1031 O O   . ALA   A 1 248 ? 136.268 145.122 161.408 1.00 95.61  ? 192 ALA   R O   1 
ATOM   1032 C CB  . ALA   A 1 248 ? 137.483 143.118 159.539 1.00 95.61  ? 192 ALA   R CB  1 
ATOM   1033 N N   . HIS   A 1 249 ? 135.221 143.286 162.196 1.00 103.58 ? 193 HIS   R N   1 
ATOM   1034 C CA  . HIS   A 1 249 ? 134.978 143.851 163.512 1.00 103.58 ? 193 HIS   R CA  1 
ATOM   1035 C C   . HIS   A 1 249 ? 135.911 143.224 164.546 1.00 103.58 ? 193 HIS   R C   1 
ATOM   1036 O O   . HIS   A 1 249 ? 136.403 142.105 164.383 1.00 103.58 ? 193 HIS   R O   1 
ATOM   1037 C CB  . HIS   A 1 249 ? 133.520 143.634 163.919 1.00 103.58 ? 193 HIS   R CB  1 
ATOM   1038 C CG  . HIS   A 1 249 ? 133.242 143.937 165.358 1.00 103.58 ? 193 HIS   R CG  1 
ATOM   1039 N ND1 . HIS   A 1 249 ? 133.452 145.183 165.909 1.00 103.58 ? 193 HIS   R ND1 1 
ATOM   1040 C CD2 . HIS   A 1 249 ? 132.782 143.155 166.362 1.00 103.58 ? 193 HIS   R CD2 1 
ATOM   1041 C CE1 . HIS   A 1 249 ? 133.126 145.156 167.189 1.00 103.58 ? 193 HIS   R CE1 1 
ATOM   1042 N NE2 . HIS   A 1 249 ? 132.716 143.937 167.489 1.00 103.58 ? 193 HIS   R NE2 1 
ATOM   1043 N N   . HIS   A 1 250 ? 136.153 143.968 165.622 1.00 110.26 ? 194 HIS   R N   1 
ATOM   1044 C CA  . HIS   A 1 250 ? 136.941 143.500 166.762 1.00 110.26 ? 194 HIS   R CA  1 
ATOM   1045 C C   . HIS   A 1 250 ? 135.956 143.166 167.882 1.00 110.26 ? 194 HIS   R C   1 
ATOM   1046 O O   . HIS   A 1 250 ? 135.529 144.041 168.636 1.00 110.26 ? 194 HIS   R O   1 
ATOM   1047 C CB  . HIS   A 1 250 ? 137.958 144.553 167.198 1.00 110.26 ? 194 HIS   R CB  1 
ATOM   1048 C CG  . HIS   A 1 250 ? 138.944 144.060 168.210 1.00 110.26 ? 194 HIS   R CG  1 
ATOM   1049 N ND1 . HIS   A 1 250 ? 139.912 143.125 167.911 1.00 110.26 ? 194 HIS   R ND1 1 
ATOM   1050 C CD2 . HIS   A 1 250 ? 139.111 144.368 169.518 1.00 110.26 ? 194 HIS   R CD2 1 
ATOM   1051 C CE1 . HIS   A 1 250 ? 140.634 142.881 168.990 1.00 110.26 ? 194 HIS   R CE1 1 
ATOM   1052 N NE2 . HIS   A 1 250 ? 140.169 143.622 169.980 1.00 110.26 ? 194 HIS   R NE2 1 
ATOM   1053 N N   . ASP   A 1 251 ? 135.598 141.889 167.983 1.00 112.27 ? 195 ASP   R N   1 
ATOM   1054 C CA  . ASP   A 1 251 ? 134.621 141.460 168.972 1.00 112.27 ? 195 ASP   R CA  1 
ATOM   1055 C C   . ASP   A 1 251 ? 135.207 141.503 170.379 1.00 112.27 ? 195 ASP   R C   1 
ATOM   1056 O O   . ASP   A 1 251 ? 136.418 141.375 170.580 1.00 112.27 ? 195 ASP   R O   1 
ATOM   1057 C CB  . ASP   A 1 251 ? 134.135 140.044 168.661 1.00 112.27 ? 195 ASP   R CB  1 
ATOM   1058 C CG  . ASP   A 1 251 ? 133.009 140.023 167.648 1.00 112.27 ? 195 ASP   R CG  1 
ATOM   1059 O OD1 . ASP   A 1 251 ? 131.997 140.719 167.870 1.00 112.27 ? 195 ASP   R OD1 1 
ATOM   1060 O OD2 . ASP   A 1 251 ? 133.136 139.309 166.630 1.00 112.27 ? 195 ASP   R OD2 1 
ATOM   1061 N N   . GLU   A 1 252 ? 134.324 141.690 171.360 1.00 115.58 ? 196 GLU   R N   1 
ATOM   1062 C CA  . GLU   A 1 252 ? 134.680 141.618 172.770 1.00 115.58 ? 196 GLU   R CA  1 
ATOM   1063 C C   . GLU   A 1 252 ? 134.238 140.314 173.419 1.00 115.58 ? 196 GLU   R C   1 
ATOM   1064 O O   . GLU   A 1 252 ? 134.629 140.042 174.559 1.00 115.58 ? 196 GLU   R O   1 
ATOM   1065 C CB  . GLU   A 1 252 ? 134.061 142.798 173.530 1.00 115.58 ? 196 GLU   R CB  1 
ATOM   1066 C CG  . GLU   A 1 252 ? 134.984 143.442 174.555 1.00 115.58 ? 196 GLU   R CG  1 
ATOM   1067 C CD  . GLU   A 1 252 ? 135.204 142.573 175.777 1.00 115.58 ? 196 GLU   R CD  1 
ATOM   1068 O OE1 . GLU   A 1 252 ? 134.205 142.129 176.381 1.00 115.58 ? 196 GLU   R OE1 1 
ATOM   1069 O OE2 . GLU   A 1 252 ? 136.376 142.335 176.135 1.00 115.58 ? 196 GLU   R OE2 1 
ATOM   1070 N N   . ARG   A 1 253 ? 133.439 139.505 172.723 1.00 115.55 ? 197 ARG   R N   1 
ATOM   1071 C CA  . ARG   A 1 253 ? 132.938 138.244 173.254 1.00 115.55 ? 197 ARG   R CA  1 
ATOM   1072 C C   . ARG   A 1 253 ? 133.924 137.098 173.065 1.00 115.55 ? 197 ARG   R C   1 
ATOM   1073 O O   . ARG   A 1 253 ? 134.080 136.264 173.964 1.00 115.55 ? 197 ARG   R O   1 
ATOM   1074 C CB  . ARG   A 1 253 ? 131.605 137.900 172.584 1.00 115.55 ? 197 ARG   R CB  1 
ATOM   1075 C CG  . ARG   A 1 253 ? 130.897 136.687 173.158 1.00 115.55 ? 197 ARG   R CG  1 
ATOM   1076 C CD  . ARG   A 1 253 ? 129.723 136.297 172.277 1.00 115.55 ? 197 ARG   R CD  1 
ATOM   1077 N NE  . ARG   A 1 253 ? 130.157 135.718 171.012 1.00 115.55 ? 197 ARG   R NE  1 
ATOM   1078 C CZ  . ARG   A 1 253 ? 129.342 135.406 170.012 1.00 115.55 ? 197 ARG   R CZ  1 
ATOM   1079 N NH1 . ARG   A 1 253 ? 128.037 135.610 170.093 1.00 115.55 ? 197 ARG   R NH1 1 
ATOM   1080 N NH2 . ARG   A 1 253 ? 129.850 134.878 168.902 1.00 115.55 ? 197 ARG   R NH2 1 
ATOM   1081 N N   . LEU   A 1 254 ? 134.594 137.039 171.912 1.00 114.93 ? 198 LEU   R N   1 
ATOM   1082 C CA  . LEU   A 1 254 ? 135.551 135.981 171.623 1.00 114.93 ? 198 LEU   R CA  1 
ATOM   1083 C C   . LEU   A 1 254 ? 136.997 136.451 171.612 1.00 114.93 ? 198 LEU   R C   1 
ATOM   1084 O O   . LEU   A 1 254 ? 137.900 135.609 171.580 1.00 114.93 ? 198 LEU   R O   1 
ATOM   1085 C CB  . LEU   A 1 254 ? 135.238 135.336 170.264 1.00 114.93 ? 198 LEU   R CB  1 
ATOM   1086 C CG  . LEU   A 1 254 ? 133.766 135.035 169.975 1.00 114.93 ? 198 LEU   R CG  1 
ATOM   1087 C CD1 . LEU   A 1 254 ? 133.614 134.408 168.597 1.00 114.93 ? 198 LEU   R CD1 1 
ATOM   1088 C CD2 . LEU   A 1 254 ? 133.182 134.128 171.046 1.00 114.93 ? 198 LEU   R CD2 1 
ATOM   1089 N N   . ASN   A 1 255 ? 137.241 137.759 171.635 1.00 113.18 ? 199 ASN   R N   1 
ATOM   1090 C CA  . ASN   A 1 255 ? 138.588 138.317 171.565 1.00 113.18 ? 199 ASN   R CA  1 
ATOM   1091 C C   . ASN   A 1 255 ? 139.279 137.981 170.250 1.00 113.18 ? 199 ASN   R C   1 
ATOM   1092 O O   . ASN   A 1 255 ? 140.508 138.055 170.154 1.00 113.18 ? 199 ASN   R O   1 
ATOM   1093 C CB  . ASN   A 1 255 ? 139.446 137.840 172.742 1.00 113.18 ? 199 ASN   R CB  1 
ATOM   1094 C CG  . ASN   A 1 255 ? 140.554 138.817 173.090 1.00 113.18 ? 199 ASN   R CG  1 
ATOM   1095 O OD1 . ASN   A 1 255 ? 140.758 139.813 172.398 1.00 113.18 ? 199 ASN   R OD1 1 
ATOM   1096 N ND2 . ASN   A 1 255 ? 141.275 138.535 174.169 1.00 113.18 ? 199 ASN   R ND2 1 
ATOM   1097 N N   . ALA   A 1 256 ? 138.510 137.608 169.232 1.00 110.41 ? 200 ALA   R N   1 
ATOM   1098 C CA  . ALA   A 1 256 ? 139.035 137.287 167.918 1.00 110.41 ? 200 ALA   R CA  1 
ATOM   1099 C C   . ALA   A 1 256 ? 138.653 138.390 166.933 1.00 110.41 ? 200 ALA   R C   1 
ATOM   1100 O O   . ALA   A 1 256 ? 138.032 139.394 167.296 1.00 110.41 ? 200 ALA   R O   1 
ATOM   1101 C CB  . ALA   A 1 256 ? 138.518 135.920 167.470 1.00 110.41 ? 200 ALA   R CB  1 
ATOM   1102 N N   . THR   A 1 257 ? 139.028 138.207 165.667 1.00 104.54 ? 201 THR   R N   1 
ATOM   1103 C CA  . THR   A 1 257 ? 138.705 139.176 164.621 1.00 104.54 ? 201 THR   R CA  1 
ATOM   1104 C C   . THR   A 1 257 ? 138.218 138.386 163.410 1.00 104.54 ? 201 THR   R C   1 
ATOM   1105 O O   . THR   A 1 257 ? 138.989 137.634 162.806 1.00 104.54 ? 201 THR   R O   1 
ATOM   1106 C CB  . THR   A 1 257 ? 139.910 140.041 164.276 1.00 104.54 ? 201 THR   R CB  1 
ATOM   1107 O OG1 . THR   A 1 257 ? 140.414 140.660 165.466 1.00 104.54 ? 201 THR   R OG1 1 
ATOM   1108 C CG2 . THR   A 1 257 ? 139.526 141.118 163.272 1.00 104.54 ? 201 THR   R CG2 1 
ATOM   1109 N N   . HIS   A 1 258 ? 136.947 138.560 163.066 1.00 103.14 ? 202 HIS   R N   1 
ATOM   1110 C CA  . HIS   A 1 258 ? 136.327 137.855 161.956 1.00 103.14 ? 202 HIS   R CA  1 
ATOM   1111 C C   . HIS   A 1 258 ? 135.718 138.855 160.983 1.00 103.14 ? 202 HIS   R C   1 
ATOM   1112 O O   . HIS   A 1 258 ? 135.806 140.072 161.165 1.00 103.14 ? 202 HIS   R O   1 
ATOM   1113 C CB  . HIS   A 1 258 ? 135.253 136.881 162.455 1.00 103.14 ? 202 HIS   R CB  1 
ATOM   1114 C CG  . HIS   A 1 258 ? 135.788 135.794 163.331 1.00 103.14 ? 202 HIS   R CG  1 
ATOM   1115 N ND1 . HIS   A 1 258 ? 136.796 134.944 162.931 1.00 103.14 ? 202 HIS   R ND1 1 
ATOM   1116 C CD2 . HIS   A 1 258 ? 135.453 135.416 164.587 1.00 103.14 ? 202 HIS   R CD2 1 
ATOM   1117 C CE1 . HIS   A 1 258 ? 137.059 134.089 163.904 1.00 103.14 ? 202 HIS   R CE1 1 
ATOM   1118 N NE2 . HIS   A 1 258 ? 136.258 134.355 164.920 1.00 103.14 ? 202 HIS   R NE2 1 
ATOM   1119 N N   . CYS   A 1 259 ? 135.104 138.320 159.932 1.00 96.90  ? 203 CYS   R N   1 
ATOM   1120 C CA  . CYS   A 1 259 ? 134.388 139.126 158.946 1.00 96.90  ? 203 CYS   R CA  1 
ATOM   1121 C C   . CYS   A 1 259 ? 132.894 138.976 159.210 1.00 96.90  ? 203 CYS   R C   1 
ATOM   1122 O O   . CYS   A 1 259 ? 132.341 137.878 159.112 1.00 96.90  ? 203 CYS   R O   1 
ATOM   1123 C CB  . CYS   A 1 259 ? 134.760 138.702 157.532 1.00 96.90  ? 203 CYS   R CB  1 
ATOM   1124 S SG  . CYS   A 1 259 ? 134.511 140.003 156.324 1.00 96.90  ? 203 CYS   R SG  1 
ATOM   1125 N N   . GLN   A 1 260 ? 132.238 140.084 159.544 1.00 93.69  ? 204 GLN   R N   1 
ATOM   1126 C CA  . GLN   A 1 260 ? 130.843 140.080 159.955 1.00 93.69  ? 204 GLN   R CA  1 
ATOM   1127 C C   . GLN   A 1 260 ? 130.137 141.315 159.414 1.00 93.69  ? 204 GLN   R C   1 
ATOM   1128 O O   . GLN   A 1 260 ? 130.747 142.188 158.789 1.00 93.69  ? 204 GLN   R O   1 
ATOM   1129 C CB  . GLN   A 1 260 ? 130.725 140.032 161.482 1.00 93.69  ? 204 GLN   R CB  1 
ATOM   1130 C CG  . GLN   A 1 260 ? 131.493 141.138 162.185 1.00 93.69  ? 204 GLN   R CG  1 
ATOM   1131 C CD  . GLN   A 1 260 ? 130.804 141.612 163.445 1.00 93.69  ? 204 GLN   R CD  1 
ATOM   1132 O OE1 . GLN   A 1 260 ? 131.274 141.364 164.554 1.00 93.69  ? 204 GLN   R OE1 1 
ATOM   1133 N NE2 . GLN   A 1 260 ? 129.683 142.303 163.281 1.00 93.69  ? 204 GLN   R NE2 1 
ATOM   1134 N N   . TYR   A 1 261 ? 128.831 141.378 159.660 1.00 88.21  ? 205 TYR   R N   1 
ATOM   1135 C CA  . TYR   A 1 261 ? 128.026 142.523 159.273 1.00 88.21  ? 205 TYR   R CA  1 
ATOM   1136 C C   . TYR   A 1 261 ? 128.045 143.583 160.373 1.00 88.21  ? 205 TYR   R C   1 
ATOM   1137 O O   . TYR   A 1 261 ? 128.464 143.336 161.506 1.00 88.21  ? 205 TYR   R O   1 
ATOM   1138 C CB  . TYR   A 1 261 ? 126.589 142.090 158.991 1.00 88.21  ? 205 TYR   R CB  1 
ATOM   1139 C CG  . TYR   A 1 261 ? 126.423 141.237 157.755 1.00 88.21  ? 205 TYR   R CG  1 
ATOM   1140 C CD1 . TYR   A 1 261 ? 126.855 139.919 157.733 1.00 88.21  ? 205 TYR   R CD1 1 
ATOM   1141 C CD2 . TYR   A 1 261 ? 125.822 141.746 156.612 1.00 88.21  ? 205 TYR   R CD2 1 
ATOM   1142 C CE1 . TYR   A 1 261 ? 126.699 139.134 156.606 1.00 88.21  ? 205 TYR   R CE1 1 
ATOM   1143 C CE2 . TYR   A 1 261 ? 125.663 140.970 155.481 1.00 88.21  ? 205 TYR   R CE2 1 
ATOM   1144 C CZ  . TYR   A 1 261 ? 126.102 139.666 155.484 1.00 88.21  ? 205 TYR   R CZ  1 
ATOM   1145 O OH  . TYR   A 1 261 ? 125.944 138.891 154.359 1.00 88.21  ? 205 TYR   R OH  1 
ATOM   1146 N N   . ASN   A 1 262 ? 127.582 144.783 160.026 1.00 89.00  ? 206 ASN   R N   1 
ATOM   1147 C CA  . ASN   A 1 262 ? 127.397 145.868 160.985 1.00 89.00  ? 206 ASN   R CA  1 
ATOM   1148 C C   . ASN   A 1 262 ? 125.980 146.415 160.896 1.00 89.00  ? 206 ASN   R C   1 
ATOM   1149 O O   . ASN   A 1 262 ? 125.728 147.597 161.146 1.00 89.00  ? 206 ASN   R O   1 
ATOM   1150 C CB  . ASN   A 1 262 ? 128.422 146.978 160.768 1.00 89.00  ? 206 ASN   R CB  1 
ATOM   1151 C CG  . ASN   A 1 262 ? 128.431 147.493 159.346 1.00 89.00  ? 206 ASN   R CG  1 
ATOM   1152 O OD1 . ASN   A 1 262 ? 127.661 148.385 158.991 1.00 89.00  ? 206 ASN   R OD1 1 
ATOM   1153 N ND2 . ASN   A 1 262 ? 129.308 146.933 158.521 1.00 89.00  ? 206 ASN   R ND2 1 
ATOM   1154 N N   . PHE   A 1 263 ? 125.036 145.552 160.533 1.00 89.22  ? 207 PHE   R N   1 
ATOM   1155 C CA  . PHE   A 1 263 ? 123.617 145.878 160.525 1.00 89.22  ? 207 PHE   R CA  1 
ATOM   1156 C C   . PHE   A 1 263 ? 123.079 145.903 161.949 1.00 89.22  ? 207 PHE   R C   1 
ATOM   1157 O O   . PHE   A 1 263 ? 123.718 145.365 162.861 1.00 89.22  ? 207 PHE   R O   1 
ATOM   1158 C CB  . PHE   A 1 263 ? 122.829 144.851 159.710 1.00 89.22  ? 207 PHE   R CB  1 
ATOM   1159 C CG  . PHE   A 1 263 ? 122.741 145.161 158.247 1.00 89.22  ? 207 PHE   R CG  1 
ATOM   1160 C CD1 . PHE   A 1 263 ? 122.003 146.242 157.799 1.00 89.22  ? 207 PHE   R CD1 1 
ATOM   1161 C CD2 . PHE   A 1 263 ? 123.375 144.357 157.318 1.00 89.22  ? 207 PHE   R CD2 1 
ATOM   1162 C CE1 . PHE   A 1 263 ? 121.910 146.522 156.455 1.00 89.22  ? 207 PHE   R CE1 1 
ATOM   1163 C CE2 . PHE   A 1 263 ? 123.285 144.633 155.974 1.00 89.22  ? 207 PHE   R CE2 1 
ATOM   1164 C CZ  . PHE   A 1 263 ? 122.549 145.717 155.542 1.00 89.22  ? 207 PHE   R CZ  1 
ATOM   1165 N N   . PRO   A 1 264 ? 121.921 146.511 162.184 1.00 90.37  ? 208 PRO   R N   1 
ATOM   1166 C CA  . PRO   A 1 264 ? 121.215 146.279 163.446 1.00 90.37  ? 208 PRO   R CA  1 
ATOM   1167 C C   . PRO   A 1 264 ? 120.748 144.833 163.530 1.00 90.37  ? 208 PRO   R C   1 
ATOM   1168 O O   . PRO   A 1 264 ? 120.496 144.169 162.523 1.00 90.37  ? 208 PRO   R O   1 
ATOM   1169 C CB  . PRO   A 1 264 ? 120.037 147.255 163.390 1.00 90.37  ? 208 PRO   R CB  1 
ATOM   1170 C CG  . PRO   A 1 264 ? 119.830 147.518 161.938 1.00 90.37  ? 208 PRO   R CG  1 
ATOM   1171 C CD  . PRO   A 1 264 ? 121.183 147.423 161.294 1.00 90.37  ? 208 PRO   R CD  1 
ATOM   1172 N N   . GLN   A 1 265 ? 120.641 144.341 164.767 1.00 94.40  ? 209 GLN   R N   1 
ATOM   1173 C CA  . GLN   A 1 265 ? 120.278 142.942 164.967 1.00 94.40  ? 209 GLN   R CA  1 
ATOM   1174 C C   . GLN   A 1 265 ? 118.989 142.590 164.235 1.00 94.40  ? 209 GLN   R C   1 
ATOM   1175 O O   . GLN   A 1 265 ? 118.853 141.473 163.723 1.00 94.40  ? 209 GLN   R O   1 
ATOM   1176 C CB  . GLN   A 1 265 ? 120.149 142.645 166.462 1.00 94.40  ? 209 GLN   R CB  1 
ATOM   1177 C CG  . GLN   A 1 265 ? 119.378 141.375 166.795 1.00 94.40  ? 209 GLN   R CG  1 
ATOM   1178 C CD  . GLN   A 1 265 ? 119.392 141.061 168.278 1.00 94.40  ? 209 GLN   R CD  1 
ATOM   1179 O OE1 . GLN   A 1 265 ? 120.063 141.734 169.061 1.00 94.40  ? 209 GLN   R OE1 1 
ATOM   1180 N NE2 . GLN   A 1 265 ? 118.645 140.037 168.674 1.00 94.40  ? 209 GLN   R NE2 1 
ATOM   1181 N N   . VAL   A 1 266 ? 118.040 143.526 164.166 1.00 92.41  ? 210 VAL   R N   1 
ATOM   1182 C CA  . VAL   A 1 266 ? 116.825 143.292 163.391 1.00 92.41  ? 210 VAL   R CA  1 
ATOM   1183 C C   . VAL   A 1 266 ? 117.161 143.159 161.911 1.00 92.41  ? 210 VAL   R C   1 
ATOM   1184 O O   . VAL   A 1 266 ? 116.592 142.320 161.202 1.00 92.41  ? 210 VAL   R O   1 
ATOM   1185 C CB  . VAL   A 1 266 ? 115.808 144.420 163.644 1.00 92.41  ? 210 VAL   R CB  1 
ATOM   1186 C CG1 . VAL   A 1 266 ? 114.676 144.355 162.630 1.00 92.41  ? 210 VAL   R CG1 1 
ATOM   1187 C CG2 . VAL   A 1 266 ? 115.269 144.333 165.064 1.00 92.41  ? 210 VAL   R CG2 1 
ATOM   1188 N N   . GLY   A 1 267 ? 118.084 143.986 161.418 1.00 90.98  ? 211 GLY   R N   1 
ATOM   1189 C CA  . GLY   A 1 267 ? 118.528 143.840 160.042 1.00 90.98  ? 211 GLY   R CA  1 
ATOM   1190 C C   . GLY   A 1 267 ? 119.214 142.509 159.799 1.00 90.98  ? 211 GLY   R C   1 
ATOM   1191 O O   . GLY   A 1 267 ? 119.035 141.889 158.747 1.00 90.98  ? 211 GLY   R O   1 
ATOM   1192 N N   . ARG   A 1 268 ? 120.012 142.054 160.767 1.00 89.98  ? 212 ARG   R N   1 
ATOM   1193 C CA  . ARG   A 1 268 ? 120.628 140.737 160.651 1.00 89.98  ? 212 ARG   R CA  1 
ATOM   1194 C C   . ARG   A 1 268 ? 119.566 139.649 160.572 1.00 89.98  ? 212 ARG   R C   1 
ATOM   1195 O O   . ARG   A 1 268 ? 119.678 138.717 159.767 1.00 89.98  ? 212 ARG   R O   1 
ATOM   1196 C CB  . ARG   A 1 268 ? 121.556 140.489 161.838 1.00 89.98  ? 212 ARG   R CB  1 
ATOM   1197 C CG  . ARG   A 1 268 ? 122.964 140.082 161.456 1.00 89.98  ? 212 ARG   R CG  1 
ATOM   1198 C CD  . ARG   A 1 268 ? 123.820 139.891 162.694 1.00 89.98  ? 212 ARG   R CD  1 
ATOM   1199 N NE  . ARG   A 1 268 ? 125.227 140.173 162.445 1.00 89.98  ? 212 ARG   R NE  1 
ATOM   1200 C CZ  . ARG   A 1 268 ? 126.159 140.212 163.387 1.00 89.98  ? 212 ARG   R CZ  1 
ATOM   1201 N NH1 . ARG   A 1 268 ? 125.865 140.003 164.660 1.00 89.98  ? 212 ARG   R NH1 1 
ATOM   1202 N NH2 . ARG   A 1 268 ? 127.418 140.467 163.043 1.00 89.98  ? 212 ARG   R NH2 1 
ATOM   1203 N N   . THR   A 1 269 ? 118.527 139.750 161.404 1.00 88.41  ? 213 THR   R N   1 
ATOM   1204 C CA  . THR   A 1 269 ? 117.443 138.775 161.356 1.00 88.41  ? 213 THR   R CA  1 
ATOM   1205 C C   . THR   A 1 269 ? 116.742 138.801 160.004 1.00 88.41  ? 213 THR   R C   1 
ATOM   1206 O O   . THR   A 1 269 ? 116.414 137.749 159.444 1.00 88.41  ? 213 THR   R O   1 
ATOM   1207 C CB  . THR   A 1 269 ? 116.442 139.048 162.478 1.00 88.41  ? 213 THR   R CB  1 
ATOM   1208 O OG1 . THR   A 1 269 ? 117.104 138.961 163.745 1.00 88.41  ? 213 THR   R OG1 1 
ATOM   1209 C CG2 . THR   A 1 269 ? 115.300 138.047 162.433 1.00 88.41  ? 213 THR   R CG2 1 
ATOM   1210 N N   . ALA   A 1 270 ? 116.494 139.996 159.470 1.00 86.10  ? 214 ALA   R N   1 
ATOM   1211 C CA  . ALA   A 1 270 ? 115.846 140.108 158.167 1.00 86.10  ? 214 ALA   R CA  1 
ATOM   1212 C C   . ALA   A 1 270 ? 116.697 139.459 157.083 1.00 86.10  ? 214 ALA   R C   1 
ATOM   1213 O O   . ALA   A 1 270 ? 116.190 138.722 156.231 1.00 86.10  ? 214 ALA   R O   1 
ATOM   1214 C CB  . ALA   A 1 270 ? 115.581 141.577 157.840 1.00 86.10  ? 214 ALA   R CB  1 
ATOM   1215 N N   . LEU   A 1 271 ? 118.004 139.726 157.101 1.00 84.66  ? 215 LEU   R N   1 
ATOM   1216 C CA  . LEU   A 1 271 ? 118.891 139.123 156.112 1.00 84.66  ? 215 LEU   R CA  1 
ATOM   1217 C C   . LEU   A 1 271 ? 118.904 137.606 156.240 1.00 84.66  ? 215 LEU   R C   1 
ATOM   1218 O O   . LEU   A 1 271 ? 118.887 136.888 155.232 1.00 84.66  ? 215 LEU   R O   1 
ATOM   1219 C CB  . LEU   A 1 271 ? 120.305 139.683 156.262 1.00 84.66  ? 215 LEU   R CB  1 
ATOM   1220 C CG  . LEU   A 1 271 ? 121.075 139.895 154.958 1.00 84.66  ? 215 LEU   R CG  1 
ATOM   1221 C CD1 . LEU   A 1 271 ? 120.624 141.169 154.260 1.00 84.66  ? 215 LEU   R CD1 1 
ATOM   1222 C CD2 . LEU   A 1 271 ? 122.571 139.929 155.225 1.00 84.66  ? 215 LEU   R CD2 1 
ATOM   1223 N N   . ARG   A 1 272 ? 118.946 137.097 157.471 1.00 84.87  ? 216 ARG   R N   1 
ATOM   1224 C CA  . ARG   A 1 272 ? 118.961 135.653 157.676 1.00 84.87  ? 216 ARG   R CA  1 
ATOM   1225 C C   . ARG   A 1 272 ? 117.671 135.020 157.168 1.00 84.87  ? 216 ARG   R C   1 
ATOM   1226 O O   . ARG   A 1 272 ? 117.690 133.954 156.542 1.00 84.87  ? 216 ARG   R O   1 
ATOM   1227 C CB  . ARG   A 1 272 ? 119.175 135.339 159.157 1.00 84.87  ? 216 ARG   R CB  1 
ATOM   1228 C CG  . ARG   A 1 272 ? 120.452 135.928 159.740 1.00 84.87  ? 216 ARG   R CG  1 
ATOM   1229 C CD  . ARG   A 1 272 ? 121.491 134.855 160.017 1.00 84.87  ? 216 ARG   R CD  1 
ATOM   1230 N NE  . ARG   A 1 272 ? 122.587 135.359 160.838 1.00 84.87  ? 216 ARG   R NE  1 
ATOM   1231 C CZ  . ARG   A 1 272 ? 123.812 135.621 160.399 1.00 84.87  ? 216 ARG   R CZ  1 
ATOM   1232 N NH1 . ARG   A 1 272 ? 124.147 135.454 159.129 1.00 84.87  ? 216 ARG   R NH1 1 
ATOM   1233 N NH2 . ARG   A 1 272 ? 124.726 136.065 161.257 1.00 84.87  ? 216 ARG   R NH2 1 
ATOM   1234 N N   . VAL   A 1 273 ? 116.534 135.669 157.428 1.00 81.47  ? 217 VAL   R N   1 
ATOM   1235 C CA  . VAL   A 1 273 ? 115.258 135.151 156.939 1.00 81.47  ? 217 VAL   R CA  1 
ATOM   1236 C C   . VAL   A 1 273 ? 115.231 135.162 155.418 1.00 81.47  ? 217 VAL   R C   1 
ATOM   1237 O O   . VAL   A 1 273 ? 114.728 134.228 154.783 1.00 81.47  ? 217 VAL   R O   1 
ATOM   1238 C CB  . VAL   A 1 273 ? 114.088 135.961 157.530 1.00 81.47  ? 217 VAL   R CB  1 
ATOM   1239 C CG1 . VAL   A 1 273 ? 112.783 135.580 156.850 1.00 81.47  ? 217 VAL   R CG1 1 
ATOM   1240 C CG2 . VAL   A 1 273 ? 113.987 135.733 159.027 1.00 81.47  ? 217 VAL   R CG2 1 
ATOM   1241 N N   . LEU   A 1 274 ? 115.757 136.226 154.809 1.00 77.97  ? 218 LEU   R N   1 
ATOM   1242 C CA  . LEU   A 1 274 ? 115.810 136.284 153.352 1.00 77.97  ? 218 LEU   R CA  1 
ATOM   1243 C C   . LEU   A 1 274 ? 116.651 135.142 152.802 1.00 77.97  ? 218 LEU   R C   1 
ATOM   1244 O O   . LEU   A 1 274 ? 116.267 134.484 151.829 1.00 77.97  ? 218 LEU   R O   1 
ATOM   1245 C CB  . LEU   A 1 274 ? 116.370 137.634 152.900 1.00 77.97  ? 218 LEU   R CB  1 
ATOM   1246 C CG  . LEU   A 1 274 ? 116.579 137.819 151.393 1.00 77.97  ? 218 LEU   R CG  1 
ATOM   1247 C CD1 . LEU   A 1 274 ? 115.360 138.479 150.769 1.00 77.97  ? 218 LEU   R CD1 1 
ATOM   1248 C CD2 . LEU   A 1 274 ? 117.834 138.632 151.116 1.00 77.97  ? 218 LEU   R CD2 1 
ATOM   1249 N N   . GLN   A 1 275 ? 117.808 134.891 153.415 1.00 78.29  ? 219 GLN   R N   1 
ATOM   1250 C CA  . GLN   A 1 275 ? 118.647 133.778 152.987 1.00 78.29  ? 219 GLN   R CA  1 
ATOM   1251 C C   . GLN   A 1 275 ? 117.887 132.464 153.095 1.00 78.29  ? 219 GLN   R C   1 
ATOM   1252 O O   . GLN   A 1 275 ? 117.869 131.656 152.161 1.00 78.29  ? 219 GLN   R O   1 
ATOM   1253 C CB  . GLN   A 1 275 ? 119.921 133.730 153.832 1.00 78.29  ? 219 GLN   R CB  1 
ATOM   1254 C CG  . GLN   A 1 275 ? 120.881 134.871 153.573 1.00 78.29  ? 219 GLN   R CG  1 
ATOM   1255 C CD  . GLN   A 1 275 ? 122.075 134.841 154.500 1.00 78.29  ? 219 GLN   R CD  1 
ATOM   1256 O OE1 . GLN   A 1 275 ? 122.010 134.287 155.596 1.00 78.29  ? 219 GLN   R OE1 1 
ATOM   1257 N NE2 . GLN   A 1 275 ? 123.175 135.441 154.065 1.00 78.29  ? 219 GLN   R NE2 1 
ATOM   1258 N N   . LEU   A 1 276 ? 117.227 132.251 154.233 1.00 77.02  ? 220 LEU   R N   1 
ATOM   1259 C CA  . LEU   A 1 276 ? 116.523 130.996 154.464 1.00 77.02  ? 220 LEU   R CA  1 
ATOM   1260 C C   . LEU   A 1 276 ? 115.427 130.779 153.428 1.00 77.02  ? 220 LEU   R C   1 
ATOM   1261 O O   . LEU   A 1 276 ? 115.278 129.680 152.883 1.00 77.02  ? 220 LEU   R O   1 
ATOM   1262 C CB  . LEU   A 1 276 ? 115.939 130.990 155.878 1.00 77.02  ? 220 LEU   R CB  1 
ATOM   1263 C CG  . LEU   A 1 276 ? 115.145 129.750 156.284 1.00 77.02  ? 220 LEU   R CG  1 
ATOM   1264 C CD1 . LEU   A 1 276 ? 116.060 128.546 156.362 1.00 77.02  ? 220 LEU   R CD1 1 
ATOM   1265 C CD2 . LEU   A 1 276 ? 114.436 129.973 157.608 1.00 77.02  ? 220 LEU   R CD2 1 
ATOM   1266 N N   . VAL   A 1 277 ? 114.651 131.828 153.133 1.00 74.75  ? 221 VAL   R N   1 
ATOM   1267 C CA  . VAL   A 1 277 ? 113.465 131.677 152.289 1.00 74.75  ? 221 VAL   R CA  1 
ATOM   1268 C C   . VAL   A 1 277 ? 113.746 131.889 150.811 1.00 74.75  ? 221 VAL   R C   1 
ATOM   1269 O O   . VAL   A 1 277 ? 112.851 131.661 149.987 1.00 74.75  ? 221 VAL   R O   1 
ATOM   1270 C CB  . VAL   A 1 277 ? 112.354 132.648 152.738 1.00 74.75  ? 221 VAL   R CB  1 
ATOM   1271 C CG1 . VAL   A 1 277 ? 111.069 132.384 151.971 1.00 74.75  ? 221 VAL   R CG1 1 
ATOM   1272 C CG2 . VAL   A 1 277 ? 112.106 132.519 154.233 1.00 74.75  ? 221 VAL   R CG2 1 
ATOM   1273 N N   . ALA   A 1 278 ? 114.955 132.308 150.440 1.00 72.51  ? 222 ALA   R N   1 
ATOM   1274 C CA  . ALA   A 1 278 ? 115.300 132.482 149.035 1.00 72.51  ? 222 ALA   R CA  1 
ATOM   1275 C C   . ALA   A 1 278 ? 116.450 131.610 148.564 1.00 72.51  ? 222 ALA   R C   1 
ATOM   1276 O O   . ALA   A 1 278 ? 116.720 131.590 147.358 1.00 72.51  ? 222 ALA   R O   1 
ATOM   1277 C CB  . ALA   A 1 278 ? 115.653 133.949 148.748 1.00 72.51  ? 222 ALA   R CB  1 
ATOM   1278 N N   . GLY   A 1 279 ? 117.134 130.897 149.455 1.00 71.24  ? 223 GLY   R N   1 
ATOM   1279 C CA  . GLY   A 1 279 ? 118.233 130.045 149.050 1.00 71.24  ? 223 GLY   R CA  1 
ATOM   1280 C C   . GLY   A 1 279 ? 117.969 128.577 149.304 1.00 71.24  ? 223 GLY   R C   1 
ATOM   1281 O O   . GLY   A 1 279 ? 118.536 127.717 148.625 1.00 71.24  ? 223 GLY   R O   1 
ATOM   1282 N N   . PHE   A 1 280 ? 117.112 128.273 150.283 1.00 70.69  ? 224 PHE   R N   1 
ATOM   1283 C CA  . PHE   A 1 280 ? 116.821 126.888 150.642 1.00 70.69  ? 224 PHE   R CA  1 
ATOM   1284 C C   . PHE   A 1 280 ? 115.368 126.529 150.359 1.00 70.69  ? 224 PHE   R C   1 
ATOM   1285 O O   . PHE   A 1 280 ? 115.115 125.582 149.612 1.00 70.69  ? 224 PHE   R O   1 
ATOM   1286 C CB  . PHE   A 1 280 ? 117.170 126.654 152.112 1.00 70.69  ? 224 PHE   R CB  1 
ATOM   1287 C CG  . PHE   A 1 280 ? 116.961 125.238 152.568 1.00 70.69  ? 224 PHE   R CG  1 
ATOM   1288 C CD1 . PHE   A 1 280 ? 117.625 124.192 151.953 1.00 70.69  ? 224 PHE   R CD1 1 
ATOM   1289 C CD2 . PHE   A 1 280 ? 116.102 124.954 153.615 1.00 70.69  ? 224 PHE   R CD2 1 
ATOM   1290 C CE1 . PHE   A 1 280 ? 117.435 122.891 152.372 1.00 70.69  ? 224 PHE   R CE1 1 
ATOM   1291 C CE2 . PHE   A 1 280 ? 115.909 123.655 154.037 1.00 70.69  ? 224 PHE   R CE2 1 
ATOM   1292 C CZ  . PHE   A 1 280 ? 116.577 122.622 153.414 1.00 70.69  ? 224 PHE   R CZ  1 
ATOM   1293 N N   . LEU   A 1 281 ? 114.402 127.257 150.921 1.00 69.81  ? 225 LEU   R N   1 
ATOM   1294 C CA  . LEU   A 1 281 ? 113.015 126.814 150.881 1.00 69.81  ? 225 LEU   R CA  1 
ATOM   1295 C C   . LEU   A 1 281 ? 112.462 126.765 149.461 1.00 69.81  ? 225 LEU   R C   1 
ATOM   1296 O O   . LEU   A 1 281 ? 111.912 125.746 149.034 1.00 69.81  ? 225 LEU   R O   1 
ATOM   1297 C CB  . LEU   A 1 281 ? 112.156 127.728 151.759 1.00 69.81  ? 225 LEU   R CB  1 
ATOM   1298 C CG  . LEU   A 1 281 ? 112.381 127.593 153.266 1.00 69.81  ? 225 LEU   R CG  1 
ATOM   1299 C CD1 . LEU   A 1 281 ? 111.518 128.589 154.018 1.00 69.81  ? 225 LEU   R CD1 1 
ATOM   1300 C CD2 . LEU   A 1 281 ? 112.106 126.175 153.745 1.00 69.81  ? 225 LEU   R CD2 1 
ATOM   1301 N N   . LEU   A 1 282 ? 112.585 127.863 148.715 1.00 65.21  ? 226 LEU   R N   1 
ATOM   1302 C CA  . LEU   A 1 282 ? 112.022 127.892 147.365 1.00 65.21  ? 226 LEU   R CA  1 
ATOM   1303 C C   . LEU   A 1 282 ? 112.714 126.902 146.437 1.00 65.21  ? 226 LEU   R C   1 
ATOM   1304 O O   . LEU   A 1 282 ? 112.019 126.128 145.752 1.00 65.21  ? 226 LEU   R O   1 
ATOM   1305 C CB  . LEU   A 1 282 ? 112.065 129.326 146.831 1.00 65.21  ? 226 LEU   R CB  1 
ATOM   1306 C CG  . LEU   A 1 282 ? 111.795 129.506 145.337 1.00 65.21  ? 226 LEU   R CG  1 
ATOM   1307 C CD1 . LEU   A 1 282 ? 110.952 130.746 145.100 1.00 65.21  ? 226 LEU   R CD1 1 
ATOM   1308 C CD2 . LEU   A 1 282 ? 113.095 129.593 144.554 1.00 65.21  ? 226 LEU   R CD2 1 
ATOM   1309 N N   . PRO   A 1 283 ? 114.051 126.873 146.345 1.00 63.23  ? 227 PRO   R N   1 
ATOM   1310 C CA  . PRO   A 1 283 ? 114.701 125.856 145.512 1.00 63.23  ? 227 PRO   R CA  1 
ATOM   1311 C C   . PRO   A 1 283 ? 114.323 124.449 145.933 1.00 63.23  ? 227 PRO   R C   1 
ATOM   1312 O O   . PRO   A 1 283 ? 114.108 123.577 145.087 1.00 63.23  ? 227 PRO   R O   1 
ATOM   1313 C CB  . PRO   A 1 283 ? 116.194 126.122 145.733 1.00 63.23  ? 227 PRO   R CB  1 
ATOM   1314 C CG  . PRO   A 1 283 ? 116.270 127.548 146.086 1.00 63.23  ? 227 PRO   R CG  1 
ATOM   1315 C CD  . PRO   A 1 283 ? 115.023 127.850 146.865 1.00 63.23  ? 227 PRO   R CD  1 
ATOM   1316 N N   . LEU   A 1 284 ? 114.232 124.220 147.245 1.00 62.72  ? 228 LEU   R N   1 
ATOM   1317 C CA  . LEU   A 1 284 ? 113.914 122.885 147.739 1.00 62.72  ? 228 LEU   R CA  1 
ATOM   1318 C C   . LEU   A 1 284 ? 112.514 122.467 147.315 1.00 62.72  ? 228 LEU   R C   1 
ATOM   1319 O O   . LEU   A 1 284 ? 112.300 121.332 146.881 1.00 62.72  ? 228 LEU   R O   1 
ATOM   1320 C CB  . LEU   A 1 284 ? 114.048 122.839 149.259 1.00 62.72  ? 228 LEU   R CB  1 
ATOM   1321 C CG  . LEU   A 1 284 ? 113.784 121.469 149.886 1.00 62.72  ? 228 LEU   R CG  1 
ATOM   1322 C CD1 . LEU   A 1 284 ? 114.973 120.551 149.667 1.00 62.72  ? 228 LEU   R CD1 1 
ATOM   1323 C CD2 . LEU   A 1 284 ? 113.472 121.611 151.364 1.00 62.72  ? 228 LEU   R CD2 1 
ATOM   1324 N N   . LEU   A 1 285 ? 111.542 123.370 147.444 1.00 59.11  ? 229 LEU   R N   1 
ATOM   1325 C CA  . LEU   A 1 285 ? 110.179 123.040 147.046 1.00 59.11  ? 229 LEU   R CA  1 
ATOM   1326 C C   . LEU   A 1 285 ? 110.089 122.797 145.546 1.00 59.11  ? 229 LEU   R C   1 
ATOM   1327 O O   . LEU   A 1 285 ? 109.411 121.862 145.097 1.00 59.11  ? 229 LEU   R O   1 
ATOM   1328 C CB  . LEU   A 1 285 ? 109.227 124.158 147.466 1.00 59.11  ? 229 LEU   R CB  1 
ATOM   1329 C CG  . LEU   A 1 285 ? 109.063 124.341 148.976 1.00 59.11  ? 229 LEU   R CG  1 
ATOM   1330 C CD1 . LEU   A 1 285 ? 108.273 125.602 149.277 1.00 59.11  ? 229 LEU   R CD1 1 
ATOM   1331 C CD2 . LEU   A 1 285 ? 108.392 123.128 149.596 1.00 59.11  ? 229 LEU   R CD2 1 
ATOM   1332 N N   . VAL   A 1 286 ? 110.769 123.626 144.752 1.00 56.38  ? 230 VAL   R N   1 
ATOM   1333 C CA  . VAL   A 1 286 ? 110.751 123.434 143.303 1.00 56.38  ? 230 VAL   R CA  1 
ATOM   1334 C C   . VAL   A 1 286 ? 111.336 122.072 142.951 1.00 56.38  ? 230 VAL   R C   1 
ATOM   1335 O O   . VAL   A 1 286 ? 110.766 121.309 142.159 1.00 56.38  ? 230 VAL   R O   1 
ATOM   1336 C CB  . VAL   A 1 286 ? 111.513 124.569 142.599 1.00 56.38  ? 230 VAL   R CB  1 
ATOM   1337 C CG1 . VAL   A 1 286 ? 111.754 124.222 141.142 1.00 56.38  ? 230 VAL   R CG1 1 
ATOM   1338 C CG2 . VAL   A 1 286 ? 110.747 125.873 142.720 1.00 56.38  ? 230 VAL   R CG2 1 
ATOM   1339 N N   . MET   A 1 287 ? 112.484 121.745 143.548 1.00 56.10  ? 231 MET   R N   1 
ATOM   1340 C CA  . MET   A 1 287 ? 113.125 120.463 143.300 1.00 56.10  ? 231 MET   R CA  1 
ATOM   1341 C C   . MET   A 1 287 ? 112.214 119.316 143.702 1.00 56.10  ? 231 MET   R C   1 
ATOM   1342 O O   . MET   A 1 287 ? 112.082 118.328 142.975 1.00 56.10  ? 231 MET   R O   1 
ATOM   1343 C CB  . MET   A 1 287 ? 114.440 120.384 144.075 1.00 56.10  ? 231 MET   R CB  1 
ATOM   1344 C CG  . MET   A 1 287 ? 115.585 121.138 143.446 1.00 56.10  ? 231 MET   R CG  1 
ATOM   1345 S SD  . MET   A 1 287 ? 117.163 120.333 143.754 1.00 56.10  ? 231 MET   R SD  1 
ATOM   1346 C CE  . MET   A 1 287 ? 118.174 121.753 144.144 1.00 56.10  ? 231 MET   R CE  1 
ATOM   1347 N N   . ALA   A 1 288 ? 111.581 119.427 144.866 1.00 53.72  ? 232 ALA   R N   1 
ATOM   1348 C CA  . ALA   A 1 288 ? 110.719 118.367 145.361 1.00 53.72  ? 232 ALA   R CA  1 
ATOM   1349 C C   . ALA   A 1 288 ? 109.584 118.121 144.383 1.00 53.72  ? 232 ALA   R C   1 
ATOM   1350 O O   . ALA   A 1 288 ? 109.371 116.987 143.952 1.00 53.72  ? 232 ALA   R O   1 
ATOM   1351 C CB  . ALA   A 1 288 ? 110.163 118.722 146.739 1.00 53.72  ? 232 ALA   R CB  1 
ATOM   1352 N N   . TYR   A 1 289 ? 108.863 119.179 144.012 1.00 49.26  ? 233 TYR   R N   1 
ATOM   1353 C CA  . TYR   A 1 289 ? 107.746 119.022 143.087 1.00 49.26  ? 233 TYR   R CA  1 
ATOM   1354 C C   . TYR   A 1 289 ? 108.203 118.393 141.777 1.00 49.26  ? 233 TYR   R C   1 
ATOM   1355 O O   . TYR   A 1 289 ? 107.656 117.373 141.329 1.00 49.26  ? 233 TYR   R O   1 
ATOM   1356 C CB  . TYR   A 1 289 ? 107.100 120.386 142.835 1.00 49.26  ? 233 TYR   R CB  1 
ATOM   1357 C CG  . TYR   A 1 289 ? 105.842 120.333 142.003 1.00 49.26  ? 233 TYR   R CG  1 
ATOM   1358 C CD1 . TYR   A 1 289 ? 104.744 119.595 142.415 1.00 49.26  ? 233 TYR   R CD1 1 
ATOM   1359 C CD2 . TYR   A 1 289 ? 105.750 121.031 140.809 1.00 49.26  ? 233 TYR   R CD2 1 
ATOM   1360 C CE1 . TYR   A 1 289 ? 103.593 119.548 141.657 1.00 49.26  ? 233 TYR   R CE1 1 
ATOM   1361 C CE2 . TYR   A 1 289 ? 104.604 120.990 140.045 1.00 49.26  ? 233 TYR   R CE2 1 
ATOM   1362 C CZ  . TYR   A 1 289 ? 103.529 120.247 140.473 1.00 49.26  ? 233 TYR   R CZ  1 
ATOM   1363 O OH  . TYR   A 1 289 ? 102.384 120.203 139.715 1.00 49.26  ? 233 TYR   R OH  1 
ATOM   1364 N N   . CYS   A 1 290 ? 109.231 118.980 141.163 1.00 48.58  ? 234 CYS   R N   1 
ATOM   1365 C CA  . CYS   A 1 290 ? 109.691 118.534 139.856 1.00 48.58  ? 234 CYS   R CA  1 
ATOM   1366 C C   . CYS   A 1 290 ? 110.140 117.081 139.897 1.00 48.58  ? 234 CYS   R C   1 
ATOM   1367 O O   . CYS   A 1 290 ? 109.685 116.265 139.089 1.00 48.58  ? 234 CYS   R O   1 
ATOM   1368 C CB  . CYS   A 1 290 ? 110.830 119.428 139.370 1.00 48.58  ? 234 CYS   R CB  1 
ATOM   1369 S SG  . CYS   A 1 290 ? 110.349 121.145 139.106 1.00 48.58  ? 234 CYS   R SG  1 
ATOM   1370 N N   . TYR   A 1 291 ? 111.020 116.736 140.838 1.00 49.15  ? 235 TYR   R N   1 
ATOM   1371 C CA  . TYR   A 1 291 ? 111.589 115.396 140.847 1.00 49.15  ? 235 TYR   R CA  1 
ATOM   1372 C C   . TYR   A 1 291 ? 110.577 114.356 141.304 1.00 49.15  ? 235 TYR   R C   1 
ATOM   1373 O O   . TYR   A 1 291 ? 110.615 113.215 140.834 1.00 49.15  ? 235 TYR   R O   1 
ATOM   1374 C CB  . TYR   A 1 291 ? 112.831 115.366 141.734 1.00 49.15  ? 235 TYR   R CB  1 
ATOM   1375 C CG  . TYR   A 1 291 ? 114.072 115.911 141.064 1.00 49.15  ? 235 TYR   R CG  1 
ATOM   1376 C CD1 . TYR   A 1 291 ? 114.411 115.545 139.769 1.00 49.15  ? 235 TYR   R CD1 1 
ATOM   1377 C CD2 . TYR   A 1 291 ? 114.905 116.795 141.728 1.00 49.15  ? 235 TYR   R CD2 1 
ATOM   1378 C CE1 . TYR   A 1 291 ? 115.540 116.042 139.160 1.00 49.15  ? 235 TYR   R CE1 1 
ATOM   1379 C CE2 . TYR   A 1 291 ? 116.037 117.297 141.126 1.00 49.15  ? 235 TYR   R CE2 1 
ATOM   1380 C CZ  . TYR   A 1 291 ? 116.349 116.918 139.843 1.00 49.15  ? 235 TYR   R CZ  1 
ATOM   1381 O OH  . TYR   A 1 291 ? 117.479 117.418 139.243 1.00 49.15  ? 235 TYR   R OH  1 
ATOM   1382 N N   . ALA   A 1 292 ? 109.661 114.713 142.206 1.00 46.21  ? 236 ALA   R N   1 
ATOM   1383 C CA  . ALA   A 1 292 ? 108.614 113.773 142.574 1.00 46.21  ? 236 ALA   R CA  1 
ATOM   1384 C C   . ALA   A 1 292 ? 107.722 113.451 141.386 1.00 46.21  ? 236 ALA   R C   1 
ATOM   1385 O O   . ALA   A 1 292 ? 107.389 112.283 141.157 1.00 46.21  ? 236 ALA   R O   1 
ATOM   1386 C CB  . ALA   A 1 292 ? 107.787 114.331 143.729 1.00 46.21  ? 236 ALA   R CB  1 
ATOM   1387 N N   . HIS   A 1 293 ? 107.333 114.462 140.602 1.00 48.11  ? 237 HIS   R N   1 
ATOM   1388 C CA  . HIS   A 1 293 ? 106.540 114.160 139.414 1.00 48.11  ? 237 HIS   R CA  1 
ATOM   1389 C C   . HIS   A 1 293 ? 107.353 113.399 138.375 1.00 48.11  ? 237 HIS   R C   1 
ATOM   1390 O O   . HIS   A 1 293 ? 106.804 112.557 137.653 1.00 48.11  ? 237 HIS   R O   1 
ATOM   1391 C CB  . HIS   A 1 293 ? 105.962 115.438 138.818 1.00 48.11  ? 237 HIS   R CB  1 
ATOM   1392 C CG  . HIS   A 1 293 ? 104.580 115.742 139.299 1.00 48.11  ? 237 HIS   R CG  1 
ATOM   1393 N ND1 . HIS   A 1 293 ? 103.501 115.841 138.448 1.00 48.11  ? 237 HIS   R ND1 1 
ATOM   1394 C CD2 . HIS   A 1 293 ? 104.097 115.947 140.546 1.00 48.11  ? 237 HIS   R CD2 1 
ATOM   1395 C CE1 . HIS   A 1 293 ? 102.414 116.106 139.150 1.00 48.11  ? 237 HIS   R CE1 1 
ATOM   1396 N NE2 . HIS   A 1 293 ? 102.748 116.176 140.426 1.00 48.11  ? 237 HIS   R NE2 1 
ATOM   1397 N N   . ILE   A 1 294 ? 108.656 113.667 138.286 1.00 47.34  ? 238 ILE   R N   1 
ATOM   1398 C CA  . ILE   A 1 294 ? 109.506 112.896 137.383 1.00 47.34  ? 238 ILE   R CA  1 
ATOM   1399 C C   . ILE   A 1 294 ? 109.493 111.426 137.780 1.00 47.34  ? 238 ILE   R C   1 
ATOM   1400 O O   . ILE   A 1 294 ? 109.365 110.536 136.932 1.00 47.34  ? 238 ILE   R O   1 
ATOM   1401 C CB  . ILE   A 1 294 ? 110.934 113.466 137.373 1.00 47.34  ? 238 ILE   R CB  1 
ATOM   1402 C CG1 . ILE   A 1 294 ? 110.967 114.777 136.589 1.00 47.34  ? 238 ILE   R CG1 1 
ATOM   1403 C CG2 . ILE   A 1 294 ? 111.900 112.448 136.785 1.00 47.34  ? 238 ILE   R CG2 1 
ATOM   1404 C CD1 . ILE   A 1 294 ? 112.307 115.476 136.602 1.00 47.34  ? 238 ILE   R CD1 1 
ATOM   1405 N N   . LEU   A 1 295 ? 109.632 111.151 139.077 1.00 49.27  ? 239 LEU   R N   1 
ATOM   1406 C CA  . LEU   A 1 295 ? 109.570 109.774 139.555 1.00 49.27  ? 239 LEU   R CA  1 
ATOM   1407 C C   . LEU   A 1 295 ? 108.217 109.156 139.241 1.00 49.27  ? 239 LEU   R C   1 
ATOM   1408 O O   . LEU   A 1 295 ? 108.130 108.005 138.800 1.00 49.27  ? 239 LEU   R O   1 
ATOM   1409 C CB  . LEU   A 1 295 ? 109.835 109.726 141.059 1.00 49.27  ? 239 LEU   R CB  1 
ATOM   1410 C CG  . LEU   A 1 295 ? 111.233 109.309 141.502 1.00 49.27  ? 239 LEU   R CG  1 
ATOM   1411 C CD1 . LEU   A 1 295 ? 112.272 110.275 140.985 1.00 49.27  ? 239 LEU   R CD1 1 
ATOM   1412 C CD2 . LEU   A 1 295 ? 111.292 109.223 143.014 1.00 49.27  ? 239 LEU   R CD2 1 
ATOM   1413 N N   . ALA   A 1 296 ? 107.144 109.917 139.460 1.00 49.64  ? 240 ALA   R N   1 
ATOM   1414 C CA  . ALA   A 1 296 ? 105.802 109.394 139.231 1.00 49.64  ? 240 ALA   R CA  1 
ATOM   1415 C C   . ALA   A 1 296 ? 105.614 109.000 137.772 1.00 49.64  ? 240 ALA   R C   1 
ATOM   1416 O O   . ALA   A 1 296 ? 105.024 107.959 137.465 1.00 49.64  ? 240 ALA   R O   1 
ATOM   1417 C CB  . ALA   A 1 296 ? 104.757 110.428 139.651 1.00 49.64  ? 240 ALA   R CB  1 
ATOM   1418 N N   . VAL   A 1 297 ? 106.105 109.831 136.852 1.00 48.69  ? 241 VAL   R N   1 
ATOM   1419 C CA  . VAL   A 1 297 ? 105.961 109.522 135.432 1.00 48.69  ? 241 VAL   R CA  1 
ATOM   1420 C C   . VAL   A 1 297 ? 106.844 108.339 135.052 1.00 48.69  ? 241 VAL   R C   1 
ATOM   1421 O O   . VAL   A 1 297 ? 106.411 107.420 134.348 1.00 48.69  ? 241 VAL   R O   1 
ATOM   1422 C CB  . VAL   A 1 297 ? 106.277 110.761 134.577 1.00 48.69  ? 241 VAL   R CB  1 
ATOM   1423 C CG1 . VAL   A 1 297 ? 106.463 110.371 133.120 1.00 48.69  ? 241 VAL   R CG1 1 
ATOM   1424 C CG2 . VAL   A 1 297 ? 105.164 111.781 134.717 1.00 48.69  ? 241 VAL   R CG2 1 
ATOM   1425 N N   . LEU   A 1 298 ? 108.094 108.338 135.516 1.00 52.39  ? 242 LEU   R N   1 
ATOM   1426 C CA  . LEU   A 1 298 ? 109.016 107.275 135.135 1.00 52.39  ? 242 LEU   R CA  1 
ATOM   1427 C C   . LEU   A 1 298 ? 108.549 105.915 135.633 1.00 52.39  ? 242 LEU   R C   1 
ATOM   1428 O O   . LEU   A 1 298 ? 108.718 104.911 134.932 1.00 52.39  ? 242 LEU   R O   1 
ATOM   1429 C CB  . LEU   A 1 298 ? 110.415 107.582 135.664 1.00 52.39  ? 242 LEU   R CB  1 
ATOM   1430 C CG  . LEU   A 1 298 ? 111.323 108.385 134.734 1.00 52.39  ? 242 LEU   R CG  1 
ATOM   1431 C CD1 . LEU   A 1 298 ? 110.570 109.504 134.058 1.00 52.39  ? 242 LEU   R CD1 1 
ATOM   1432 C CD2 . LEU   A 1 298 ? 112.494 108.948 135.513 1.00 52.39  ? 242 LEU   R CD2 1 
ATOM   1433 N N   . LEU   A 1 299 ? 107.968 105.851 136.832 1.00 56.62  ? 243 LEU   R N   1 
ATOM   1434 C CA  . LEU   A 1 299 ? 107.472 104.583 137.353 1.00 56.62  ? 243 LEU   R CA  1 
ATOM   1435 C C   . LEU   A 1 299 ? 106.275 104.054 136.576 1.00 56.62  ? 243 LEU   R C   1 
ATOM   1436 O O   . LEU   A 1 299 ? 105.895 102.893 136.770 1.00 56.62  ? 243 LEU   R O   1 
ATOM   1437 C CB  . LEU   A 1 299 ? 107.088 104.718 138.829 1.00 56.62  ? 243 LEU   R CB  1 
ATOM   1438 C CG  . LEU   A 1 299 ? 108.254 104.922 139.796 1.00 56.62  ? 243 LEU   R CG  1 
ATOM   1439 C CD1 . LEU   A 1 299 ? 107.872 105.857 140.931 1.00 56.62  ? 243 LEU   R CD1 1 
ATOM   1440 C CD2 . LEU   A 1 299 ? 108.714 103.583 140.340 1.00 56.62  ? 243 LEU   R CD2 1 
ATOM   1441 N N   . VAL   A 1 300 ? 105.677 104.867 135.712 1.00 58.65  ? 244 VAL   R N   1 
ATOM   1442 C CA  . VAL   A 1 300 ? 104.550 104.442 134.895 1.00 58.65  ? 244 VAL   R CA  1 
ATOM   1443 C C   . VAL   A 1 300 ? 104.925 104.396 133.411 1.00 58.65  ? 244 VAL   R C   1 
ATOM   1444 O O   . VAL   A 1 300 ? 104.047 104.396 132.550 1.00 58.65  ? 244 VAL   R O   1 
ATOM   1445 C CB  . VAL   A 1 300 ? 103.323 105.335 135.135 1.00 58.65  ? 244 VAL   R CB  1 
ATOM   1446 C CG1 . VAL   A 1 300 ? 102.086 104.748 134.467 1.00 58.65  ? 244 VAL   R CG1 1 
ATOM   1447 C CG2 . VAL   A 1 300 ? 103.082 105.516 136.628 1.00 58.65  ? 244 VAL   R CG2 1 
ATOM   1448 N N   . SER   A 1 301 ? 106.218 104.352 133.100 1.00 64.14  ? 245 SER   R N   1 
ATOM   1449 C CA  . SER   A 1 301 ? 106.695 104.290 131.729 1.00 64.14  ? 245 SER   R CA  1 
ATOM   1450 C C   . SER   A 1 301 ? 107.057 102.850 131.370 1.00 64.14  ? 245 SER   R C   1 
ATOM   1451 O O   . SER   A 1 301 ? 106.835 101.915 132.145 1.00 64.14  ? 245 SER   R O   1 
ATOM   1452 C CB  . SER   A 1 301 ? 107.890 105.226 131.546 1.00 64.14  ? 245 SER   R CB  1 
ATOM   1453 O OG  . SER   A 1 301 ? 109.062 104.668 132.116 1.00 64.14  ? 245 SER   R OG  1 
ATOM   1454 N N   . ARG   A 1 302 ? 107.624 102.667 130.179 1.00 70.94  ? 246 ARG   R N   1 
ATOM   1455 C CA  . ARG   A 1 302 ? 108.052 101.356 129.707 1.00 70.94  ? 246 ARG   R CA  1 
ATOM   1456 C C   . ARG   A 1 302 ? 109.419 101.501 129.058 1.00 70.94  ? 246 ARG   R C   1 
ATOM   1457 O O   . ARG   A 1 302 ? 109.550 102.171 128.029 1.00 70.94  ? 246 ARG   R O   1 
ATOM   1458 C CB  . ARG   A 1 302 ? 107.045 100.771 128.712 1.00 70.94  ? 246 ARG   R CB  1 
ATOM   1459 C CG  . ARG   A 1 302 ? 107.244 99.290  128.427 1.00 70.94  ? 246 ARG   R CG  1 
ATOM   1460 C CD  . ARG   A 1 302 ? 107.077 98.974  126.947 1.00 70.94  ? 246 ARG   R CD  1 
ATOM   1461 N NE  . ARG   A 1 302 ? 105.867 99.569  126.389 1.00 70.94  ? 246 ARG   R NE  1 
ATOM   1462 C CZ  . ARG   A 1 302 ? 104.717 98.931  126.214 1.00 70.94  ? 246 ARG   R CZ  1 
ATOM   1463 N NH1 . ARG   A 1 302 ? 104.567 97.661  126.557 1.00 70.94  ? 246 ARG   R NH1 1 
ATOM   1464 N NH2 . ARG   A 1 302 ? 103.688 99.585  125.682 1.00 70.94  ? 246 ARG   R NH2 1 
ATOM   1465 N N   . GLY   A 1 303 ? 110.428 100.878 129.653 1.00 74.08  ? 247 GLY   R N   1 
ATOM   1466 C CA  . GLY   A 1 303 ? 111.767 100.927 129.101 1.00 74.08  ? 247 GLY   R CA  1 
ATOM   1467 C C   . GLY   A 1 303 ? 112.774 100.414 130.102 1.00 74.08  ? 247 GLY   R C   1 
ATOM   1468 O O   . GLY   A 1 303 ? 112.450 100.109 131.253 1.00 74.08  ? 247 GLY   R O   1 
ATOM   1469 N N   . GLN   A 1 304 ? 114.018 100.318 129.636 1.00 77.37  ? 248 GLN   R N   1 
ATOM   1470 C CA  . GLN   A 1 304 ? 115.130 99.862  130.460 1.00 77.37  ? 248 GLN   R CA  1 
ATOM   1471 C C   . GLN   A 1 304 ? 115.959 101.015 131.014 1.00 77.37  ? 248 GLN   R C   1 
ATOM   1472 O O   . GLN   A 1 304 ? 116.905 100.776 131.771 1.00 77.37  ? 248 GLN   R O   1 
ATOM   1473 C CB  . GLN   A 1 304 ? 116.029 98.916  129.660 1.00 77.37  ? 248 GLN   R CB  1 
ATOM   1474 C CG  . GLN   A 1 304 ? 115.299 97.742  129.022 1.00 77.37  ? 248 GLN   R CG  1 
ATOM   1475 C CD  . GLN   A 1 304 ? 115.080 96.597  129.991 1.00 77.37  ? 248 GLN   R CD  1 
ATOM   1476 O OE1 . GLN   A 1 304 ? 114.274 96.697  130.917 1.00 77.37  ? 248 GLN   R OE1 1 
ATOM   1477 N NE2 . GLN   A 1 304 ? 115.798 95.500  129.783 1.00 77.37  ? 248 GLN   R NE2 1 
ATOM   1478 N N   . ARG   A 1 305 ? 115.628 102.256 130.659 1.00 71.22  ? 249 ARG   R N   1 
ATOM   1479 C CA  . ARG   A 1 305 ? 116.341 103.426 131.154 1.00 71.22  ? 249 ARG   R CA  1 
ATOM   1480 C C   . ARG   A 1 305 ? 115.640 104.115 132.311 1.00 71.22  ? 249 ARG   R C   1 
ATOM   1481 O O   . ARG   A 1 305 ? 116.239 104.981 132.952 1.00 71.22  ? 249 ARG   R O   1 
ATOM   1482 C CB  . ARG   A 1 305 ? 116.542 104.441 130.023 1.00 71.22  ? 249 ARG   R CB  1 
ATOM   1483 C CG  . ARG   A 1 305 ? 117.477 103.959 128.927 1.00 71.22  ? 249 ARG   R CG  1 
ATOM   1484 C CD  . ARG   A 1 305 ? 117.468 104.896 127.732 1.00 71.22  ? 249 ARG   R CD  1 
ATOM   1485 N NE  . ARG   A 1 305 ? 118.643 104.713 126.889 1.00 71.22  ? 249 ARG   R NE  1 
ATOM   1486 C CZ  . ARG   A 1 305 ? 118.849 105.342 125.740 1.00 71.22  ? 249 ARG   R CZ  1 
ATOM   1487 N NH1 . ARG   A 1 305 ? 117.975 106.212 125.261 1.00 71.22  ? 249 ARG   R NH1 1 
ATOM   1488 N NH2 . ARG   A 1 305 ? 119.961 105.092 125.054 1.00 71.22  ? 249 ARG   R NH2 1 
ATOM   1489 N N   . ARG   A 1 306 ? 114.386 103.756 132.590 1.00 64.25  ? 250 ARG   R N   1 
ATOM   1490 C CA  . ARG   A 1 306 ? 113.674 104.352 133.714 1.00 64.25  ? 250 ARG   R CA  1 
ATOM   1491 C C   . ARG   A 1 306 ? 114.329 104.003 135.044 1.00 64.25  ? 250 ARG   R C   1 
ATOM   1492 O O   . ARG   A 1 306 ? 114.284 104.800 135.987 1.00 64.25  ? 250 ARG   R O   1 
ATOM   1493 C CB  . ARG   A 1 306 ? 112.215 103.894 133.698 1.00 64.25  ? 250 ARG   R CB  1 
ATOM   1494 C CG  . ARG   A 1 306 ? 112.044 102.391 133.874 1.00 64.25  ? 250 ARG   R CG  1 
ATOM   1495 C CD  . ARG   A 1 306 ? 110.923 101.843 133.004 1.00 64.25  ? 250 ARG   R CD  1 
ATOM   1496 N NE  . ARG   A 1 306 ? 109.601 102.206 133.498 1.00 64.25  ? 250 ARG   R NE  1 
ATOM   1497 C CZ  . ARG   A 1 306 ? 109.038 101.689 134.582 1.00 64.25  ? 250 ARG   R CZ  1 
ATOM   1498 N NH1 . ARG   A 1 306 ? 109.660 100.784 135.321 1.00 64.25  ? 250 ARG   R NH1 1 
ATOM   1499 N NH2 . ARG   A 1 306 ? 107.818 102.085 134.930 1.00 64.25  ? 250 ARG   R NH2 1 
ATOM   1500 N N   . LEU   A 1 307 ? 114.942 102.823 135.141 1.00 64.53  ? 251 LEU   R N   1 
ATOM   1501 C CA  . LEU   A 1 307 ? 115.566 102.384 136.384 1.00 64.53  ? 251 LEU   R CA  1 
ATOM   1502 C C   . LEU   A 1 307 ? 116.644 103.364 136.830 1.00 64.53  ? 251 LEU   R C   1 
ATOM   1503 O O   . LEU   A 1 307 ? 116.545 103.964 137.909 1.00 64.53  ? 251 LEU   R O   1 
ATOM   1504 C CB  . LEU   A 1 307 ? 116.167 100.986 136.216 1.00 64.53  ? 251 LEU   R CB  1 
ATOM   1505 C CG  . LEU   A 1 307 ? 115.212 99.789  136.281 1.00 64.53  ? 251 LEU   R CG  1 
ATOM   1506 C CD1 . LEU   A 1 307 ? 114.667 99.600  137.690 1.00 64.53  ? 251 LEU   R CD1 1 
ATOM   1507 C CD2 . LEU   A 1 307 ? 114.073 99.939  135.283 1.00 64.53  ? 251 LEU   R CD2 1 
ATOM   1508 N N   . ARG   A 1 308 ? 117.683 103.523 136.006 1.00 61.57  ? 252 ARG   R N   1 
ATOM   1509 C CA  . ARG   A 1 308 ? 118.750 104.450 136.355 1.00 61.57  ? 252 ARG   R CA  1 
ATOM   1510 C C   . ARG   A 1 308 ? 118.230 105.871 136.480 1.00 61.57  ? 252 ARG   R C   1 
ATOM   1511 O O   . ARG   A 1 308 ? 118.776 106.660 137.253 1.00 61.57  ? 252 ARG   R O   1 
ATOM   1512 C CB  . ARG   A 1 308 ? 119.872 104.396 135.321 1.00 61.57  ? 252 ARG   R CB  1 
ATOM   1513 C CG  . ARG   A 1 308 ? 121.022 103.493 135.717 1.00 61.57  ? 252 ARG   R CG  1 
ATOM   1514 C CD  . ARG   A 1 308 ? 121.992 103.306 134.570 1.00 61.57  ? 252 ARG   R CD  1 
ATOM   1515 N NE  . ARG   A 1 308 ? 122.595 104.572 134.167 1.00 61.57  ? 252 ARG   R NE  1 
ATOM   1516 C CZ  . ARG   A 1 308 ? 123.892 104.767 133.959 1.00 61.57  ? 252 ARG   R CZ  1 
ATOM   1517 N NH1 . ARG   A 1 308 ? 124.774 103.790 134.094 1.00 61.57  ? 252 ARG   R NH1 1 
ATOM   1518 N NH2 . ARG   A 1 308 ? 124.314 105.977 133.603 1.00 61.57  ? 252 ARG   R NH2 1 
ATOM   1519 N N   . ALA   A 1 309 ? 117.178 106.219 135.740 1.00 59.12  ? 253 ALA   R N   1 
ATOM   1520 C CA  . ALA   A 1 309 ? 116.616 107.559 135.856 1.00 59.12  ? 253 ALA   R CA  1 
ATOM   1521 C C   . ALA   A 1 309 ? 116.083 107.801 137.263 1.00 59.12  ? 253 ALA   R C   1 
ATOM   1522 O O   . ALA   A 1 309 ? 116.435 108.793 137.914 1.00 59.12  ? 253 ALA   R O   1 
ATOM   1523 C CB  . ALA   A 1 309 ? 115.516 107.756 134.814 1.00 59.12  ? 253 ALA   R CB  1 
ATOM   1524 N N   . MET   A 1 310 ? 115.238 106.892 137.757 1.00 57.54  ? 254 MET   R N   1 
ATOM   1525 C CA  . MET   A 1 310 ? 114.727 107.038 139.115 1.00 57.54  ? 254 MET   R CA  1 
ATOM   1526 C C   . MET   A 1 310 ? 115.862 107.015 140.126 1.00 57.54  ? 254 MET   R C   1 
ATOM   1527 O O   . MET   A 1 310 ? 115.874 107.806 141.076 1.00 57.54  ? 254 MET   R O   1 
ATOM   1528 C CB  . MET   A 1 310 ? 113.728 105.929 139.447 1.00 57.54  ? 254 MET   R CB  1 
ATOM   1529 C CG  . MET   A 1 310 ? 112.567 105.785 138.495 1.00 57.54  ? 254 MET   R CG  1 
ATOM   1530 S SD  . MET   A 1 310 ? 111.771 104.187 138.734 1.00 57.54  ? 254 MET   R SD  1 
ATOM   1531 C CE  . MET   A 1 310 ? 111.049 103.914 137.122 1.00 57.54  ? 254 MET   R CE  1 
ATOM   1532 N N   . ARG   A 1 311 ? 116.820 106.104 139.951 1.00 58.06  ? 255 ARG   R N   1 
ATOM   1533 C CA  . ARG   A 1 311 ? 117.897 105.996 140.928 1.00 58.06  ? 255 ARG   R CA  1 
ATOM   1534 C C   . ARG   A 1 311 ? 118.711 107.284 140.985 1.00 58.06  ? 255 ARG   R C   1 
ATOM   1535 O O   . ARG   A 1 311 ? 119.020 107.789 142.070 1.00 58.06  ? 255 ARG   R O   1 
ATOM   1536 C CB  . ARG   A 1 311 ? 118.787 104.801 140.598 1.00 58.06  ? 255 ARG   R CB  1 
ATOM   1537 C CG  . ARG   A 1 311 ? 118.168 103.473 140.992 1.00 58.06  ? 255 ARG   R CG  1 
ATOM   1538 C CD  . ARG   A 1 311 ? 119.121 102.314 140.774 1.00 58.06  ? 255 ARG   R CD  1 
ATOM   1539 N NE  . ARG   A 1 311 ? 118.691 101.127 141.502 1.00 58.06  ? 255 ARG   R NE  1 
ATOM   1540 C CZ  . ARG   A 1 311 ? 119.361 99.983  141.540 1.00 58.06  ? 255 ARG   R CZ  1 
ATOM   1541 N NH1 . ARG   A 1 311 ? 120.505 99.830  140.894 1.00 58.06  ? 255 ARG   R NH1 1 
ATOM   1542 N NH2 . ARG   A 1 311 ? 118.870 98.967  142.243 1.00 58.06  ? 255 ARG   R NH2 1 
ATOM   1543 N N   . LEU   A 1 312 ? 119.051 107.842 139.822 1.00 56.38  ? 256 LEU   R N   1 
ATOM   1544 C CA  . LEU   A 1 312 ? 119.817 109.081 139.790 1.00 56.38  ? 256 LEU   R CA  1 
ATOM   1545 C C   . LEU   A 1 312 ? 119.025 110.237 140.380 1.00 56.38  ? 256 LEU   R C   1 
ATOM   1546 O O   . LEU   A 1 312 ? 119.581 111.062 141.113 1.00 56.38  ? 256 LEU   R O   1 
ATOM   1547 C CB  . LEU   A 1 312 ? 120.236 109.404 138.357 1.00 56.38  ? 256 LEU   R CB  1 
ATOM   1548 C CG  . LEU   A 1 312 ? 121.681 109.072 137.983 1.00 56.38  ? 256 LEU   R CG  1 
ATOM   1549 C CD1 . LEU   A 1 312 ? 121.923 109.358 136.514 1.00 56.38  ? 256 LEU   R CD1 1 
ATOM   1550 C CD2 . LEU   A 1 312 ? 122.657 109.858 138.842 1.00 56.38  ? 256 LEU   R CD2 1 
ATOM   1551 N N   . VAL   A 1 313 ? 117.729 110.324 140.073 1.00 51.68  ? 257 VAL   R N   1 
ATOM   1552 C CA  . VAL   A 1 313 ? 116.923 111.411 140.620 1.00 51.68  ? 257 VAL   R CA  1 
ATOM   1553 C C   . VAL   A 1 313 ? 116.875 111.318 142.139 1.00 51.68  ? 257 VAL   R C   1 
ATOM   1554 O O   . VAL   A 1 313 ? 117.026 112.321 142.850 1.00 51.68  ? 257 VAL   R O   1 
ATOM   1555 C CB  . VAL   A 1 313 ? 115.512 111.393 140.012 1.00 51.68  ? 257 VAL   R CB  1 
ATOM   1556 C CG1 . VAL   A 1 313 ? 114.610 112.346 140.768 1.00 51.68  ? 257 VAL   R CG1 1 
ATOM   1557 C CG2 . VAL   A 1 313 ? 115.568 111.761 138.543 1.00 51.68  ? 257 VAL   R CG2 1 
ATOM   1558 N N   . VAL   A 1 314 ? 116.660 110.109 142.660 1.00 53.05  ? 258 VAL   R N   1 
ATOM   1559 C CA  . VAL   A 1 314 ? 116.593 109.925 144.106 1.00 53.05  ? 258 VAL   R CA  1 
ATOM   1560 C C   . VAL   A 1 314 ? 117.926 110.282 144.745 1.00 53.05  ? 258 VAL   R C   1 
ATOM   1561 O O   . VAL   A 1 314 ? 117.976 110.936 145.793 1.00 53.05  ? 258 VAL   R O   1 
ATOM   1562 C CB  . VAL   A 1 314 ? 116.175 108.483 144.444 1.00 53.05  ? 258 VAL   R CB  1 
ATOM   1563 C CG1 . VAL   A 1 314 ? 116.332 108.225 145.930 1.00 53.05  ? 258 VAL   R CG1 1 
ATOM   1564 C CG2 . VAL   A 1 314 ? 114.743 108.236 144.011 1.00 53.05  ? 258 VAL   R CG2 1 
ATOM   1565 N N   . VAL   A 1 315 ? 119.029 109.851 144.131 1.00 55.02  ? 259 VAL   R N   1 
ATOM   1566 C CA  . VAL   A 1 315 ? 120.347 110.156 144.680 1.00 55.02  ? 259 VAL   R CA  1 
ATOM   1567 C C   . VAL   A 1 315 ? 120.568 111.662 144.709 1.00 55.02  ? 259 VAL   R C   1 
ATOM   1568 O O   . VAL   A 1 315 ? 121.078 112.214 145.689 1.00 55.02  ? 259 VAL   R O   1 
ATOM   1569 C CB  . VAL   A 1 315 ? 121.444 109.440 143.874 1.00 55.02  ? 259 VAL   R CB  1 
ATOM   1570 C CG1 . VAL   A 1 315 ? 122.804 110.028 144.190 1.00 55.02  ? 259 VAL   R CG1 1 
ATOM   1571 C CG2 . VAL   A 1 315 ? 121.427 107.952 144.172 1.00 55.02  ? 259 VAL   R CG2 1 
ATOM   1572 N N   . VAL   A 1 316 ? 120.190 112.349 143.631 1.00 55.22  ? 260 VAL   R N   1 
ATOM   1573 C CA  . VAL   A 1 316 ? 120.378 113.796 143.568 1.00 55.22  ? 260 VAL   R CA  1 
ATOM   1574 C C   . VAL   A 1 316 ? 119.577 114.483 144.668 1.00 55.22  ? 260 VAL   R C   1 
ATOM   1575 O O   . VAL   A 1 316 ? 120.083 115.366 145.374 1.00 55.22  ? 260 VAL   R O   1 
ATOM   1576 C CB  . VAL   A 1 316 ? 119.987 114.325 142.177 1.00 55.22  ? 260 VAL   R CB  1 
ATOM   1577 C CG1 . VAL   A 1 316 ? 119.885 115.836 142.194 1.00 55.22  ? 260 VAL   R CG1 1 
ATOM   1578 C CG2 . VAL   A 1 316 ? 120.993 113.873 141.135 1.00 55.22  ? 260 VAL   R CG2 1 
ATOM   1579 N N   . VAL   A 1 317 ? 118.312 114.090 144.828 1.00 54.24  ? 261 VAL   R N   1 
ATOM   1580 C CA  . VAL   A 1 317 ? 117.462 114.734 145.827 1.00 54.24  ? 261 VAL   R CA  1 
ATOM   1581 C C   . VAL   A 1 317 ? 118.004 114.478 147.228 1.00 54.24  ? 261 VAL   R C   1 
ATOM   1582 O O   . VAL   A 1 317 ? 118.056 115.384 148.070 1.00 54.24  ? 261 VAL   R O   1 
ATOM   1583 C CB  . VAL   A 1 317 ? 116.008 114.250 145.687 1.00 54.24  ? 261 VAL   R CB  1 
ATOM   1584 C CG1 . VAL   A 1 317 ? 115.170 114.747 146.849 1.00 54.24  ? 261 VAL   R CG1 1 
ATOM   1585 C CG2 . VAL   A 1 317 ? 115.422 114.723 144.370 1.00 54.24  ? 261 VAL   R CG2 1 
ATOM   1586 N N   . VAL   A 1 318 ? 118.413 113.237 147.501 1.00 57.14  ? 262 VAL   R N   1 
ATOM   1587 C CA  . VAL   A 1 318 ? 118.939 112.899 148.821 1.00 57.14  ? 262 VAL   R CA  1 
ATOM   1588 C C   . VAL   A 1 318 ? 120.215 113.681 149.099 1.00 57.14  ? 262 VAL   R C   1 
ATOM   1589 O O   . VAL   A 1 318 ? 120.429 114.179 150.210 1.00 57.14  ? 262 VAL   R O   1 
ATOM   1590 C CB  . VAL   A 1 318 ? 119.173 111.383 148.931 1.00 57.14  ? 262 VAL   R CB  1 
ATOM   1591 C CG1 . VAL   A 1 318 ? 120.025 111.064 150.145 1.00 57.14  ? 262 VAL   R CG1 1 
ATOM   1592 C CG2 . VAL   A 1 318 ? 117.847 110.648 149.006 1.00 57.14  ? 262 VAL   R CG2 1 
ATOM   1593 N N   . ALA   A 1 319 ? 121.095 113.779 148.102 1.00 59.37  ? 263 ALA   R N   1 
ATOM   1594 C CA  . ALA   A 1 319 ? 122.326 114.538 148.276 1.00 59.37  ? 263 ALA   R CA  1 
ATOM   1595 C C   . ALA   A 1 319 ? 122.017 115.990 148.606 1.00 59.37  ? 263 ALA   R C   1 
ATOM   1596 O O   . ALA   A 1 319 ? 122.548 116.548 149.572 1.00 59.37  ? 263 ALA   R O   1 
ATOM   1597 C CB  . ALA   A 1 319 ? 123.184 114.441 147.015 1.00 59.37  ? 263 ALA   R CB  1 
ATOM   1598 N N   . PHE   A 1 320 ? 121.143 116.618 147.818 1.00 63.21  ? 264 PHE   R N   1 
ATOM   1599 C CA  . PHE   A 1 320 ? 120.795 118.009 148.078 1.00 63.21  ? 264 PHE   R CA  1 
ATOM   1600 C C   . PHE   A 1 320 ? 120.252 118.178 149.490 1.00 63.21  ? 264 PHE   R C   1 
ATOM   1601 O O   . PHE   A 1 320 ? 120.685 119.061 150.238 1.00 63.21  ? 264 PHE   R O   1 
ATOM   1602 C CB  . PHE   A 1 320 ? 119.773 118.504 147.056 1.00 63.21  ? 264 PHE   R CB  1 
ATOM   1603 C CG  . PHE   A 1 320 ? 119.431 119.957 147.209 1.00 63.21  ? 264 PHE   R CG  1 
ATOM   1604 C CD1 . PHE   A 1 320 ? 120.301 120.938 146.773 1.00 63.21  ? 264 PHE   R CD1 1 
ATOM   1605 C CD2 . PHE   A 1 320 ? 118.244 120.341 147.805 1.00 63.21  ? 264 PHE   R CD2 1 
ATOM   1606 C CE1 . PHE   A 1 320 ? 119.989 122.275 146.918 1.00 63.21  ? 264 PHE   R CE1 1 
ATOM   1607 C CE2 . PHE   A 1 320 ? 117.927 121.676 147.953 1.00 63.21  ? 264 PHE   R CE2 1 
ATOM   1608 C CZ  . PHE   A 1 320 ? 118.802 122.644 147.509 1.00 63.21  ? 264 PHE   R CZ  1 
ATOM   1609 N N   . ALA   A 1 321 ? 119.300 117.328 149.876 1.00 64.65  ? 265 ALA   R N   1 
ATOM   1610 C CA  . ALA   A 1 321 ? 118.697 117.449 151.196 1.00 64.65  ? 265 ALA   R CA  1 
ATOM   1611 C C   . ALA   A 1 321 ? 119.746 117.309 152.292 1.00 64.65  ? 265 ALA   R C   1 
ATOM   1612 O O   . ALA   A 1 321 ? 119.942 118.216 153.107 1.00 64.65  ? 265 ALA   R O   1 
ATOM   1613 C CB  . ALA   A 1 321 ? 117.596 116.401 151.363 1.00 64.65  ? 265 ALA   R CB  1 
ATOM   1614 N N   . LEU   A 1 322 ? 120.453 116.180 152.312 1.00 65.91  ? 266 LEU   R N   1 
ATOM   1615 C CA  . LEU   A 1 322 ? 121.368 115.892 153.409 1.00 65.91  ? 266 LEU   R CA  1 
ATOM   1616 C C   . LEU   A 1 322 ? 122.673 116.668 153.321 1.00 65.91  ? 266 LEU   R C   1 
ATOM   1617 O O   . LEU   A 1 322 ? 123.530 116.481 154.192 1.00 65.91  ? 266 LEU   R O   1 
ATOM   1618 C CB  . LEU   A 1 322 ? 121.663 114.391 153.463 1.00 65.91  ? 266 LEU   R CB  1 
ATOM   1619 C CG  . LEU   A 1 322 ? 120.515 113.461 153.878 1.00 65.91  ? 266 LEU   R CG  1 
ATOM   1620 C CD1 . LEU   A 1 322 ? 121.067 112.145 154.400 1.00 65.91  ? 266 LEU   R CD1 1 
ATOM   1621 C CD2 . LEU   A 1 322 ? 119.598 114.099 154.916 1.00 65.91  ? 266 LEU   R CD2 1 
ATOM   1622 N N   . CYS   A 1 323 ? 122.860 117.516 152.311 1.00 71.57  ? 267 CYS   R N   1 
ATOM   1623 C CA  . CYS   A 1 323 ? 124.009 118.410 152.282 1.00 71.57  ? 267 CYS   R CA  1 
ATOM   1624 C C   . CYS   A 1 323 ? 123.651 119.872 152.486 1.00 71.57  ? 267 CYS   R C   1 
ATOM   1625 O O   . CYS   A 1 323 ? 124.531 120.659 152.839 1.00 71.57  ? 267 CYS   R O   1 
ATOM   1626 C CB  . CYS   A 1 323 ? 124.759 118.269 150.953 1.00 71.57  ? 267 CYS   R CB  1 
ATOM   1627 S SG  . CYS   A 1 323 ? 126.018 116.970 150.958 1.00 71.57  ? 267 CYS   R SG  1 
ATOM   1628 N N   . TRP   A 1 324 ? 122.393 120.261 152.275 1.00 72.06  ? 268 TRP   R N   1 
ATOM   1629 C CA  . TRP   A 1 324 ? 121.998 121.649 152.482 1.00 72.06  ? 268 TRP   R CA  1 
ATOM   1630 C C   . TRP   A 1 324 ? 121.200 121.850 153.764 1.00 72.06  ? 268 TRP   R C   1 
ATOM   1631 O O   . TRP   A 1 324 ? 121.381 122.864 154.445 1.00 72.06  ? 268 TRP   R O   1 
ATOM   1632 C CB  . TRP   A 1 324 ? 121.184 122.146 151.287 1.00 72.06  ? 268 TRP   R CB  1 
ATOM   1633 C CG  . TRP   A 1 324 ? 122.035 122.594 150.144 1.00 72.06  ? 268 TRP   R CG  1 
ATOM   1634 C CD1 . TRP   A 1 324 ? 123.093 121.927 149.604 1.00 72.06  ? 268 TRP   R CD1 1 
ATOM   1635 C CD2 . TRP   A 1 324 ? 121.903 123.808 149.398 1.00 72.06  ? 268 TRP   R CD2 1 
ATOM   1636 N NE1 . TRP   A 1 324 ? 123.630 122.651 148.567 1.00 72.06  ? 268 TRP   R NE1 1 
ATOM   1637 C CE2 . TRP   A 1 324 ? 122.916 123.810 148.421 1.00 72.06  ? 268 TRP   R CE2 1 
ATOM   1638 C CE3 . TRP   A 1 324 ? 121.027 124.894 149.462 1.00 72.06  ? 268 TRP   R CE3 1 
ATOM   1639 C CZ2 . TRP   A 1 324 ? 123.077 124.852 147.516 1.00 72.06  ? 268 TRP   R CZ2 1 
ATOM   1640 C CZ3 . TRP   A 1 324 ? 121.190 125.928 148.562 1.00 72.06  ? 268 TRP   R CZ3 1 
ATOM   1641 C CH2 . TRP   A 1 324 ? 122.206 125.899 147.602 1.00 72.06  ? 268 TRP   R CH2 1 
ATOM   1642 N N   . THR   A 1 325 ? 120.320 120.912 154.113 1.00 74.15  ? 269 THR   R N   1 
ATOM   1643 C CA  . THR   A 1 325 ? 119.453 121.091 155.275 1.00 74.15  ? 269 THR   R CA  1 
ATOM   1644 C C   . THR   A 1 325 ? 120.211 121.428 156.552 1.00 74.15  ? 269 THR   R C   1 
ATOM   1645 O O   . THR   A 1 325 ? 119.719 122.262 157.326 1.00 74.15  ? 269 THR   R O   1 
ATOM   1646 C CB  . THR   A 1 325 ? 118.607 119.826 155.471 1.00 74.15  ? 269 THR   R CB  1 
ATOM   1647 O OG1 . THR   A 1 325 ? 117.941 119.500 154.245 1.00 74.15  ? 269 THR   R OG1 1 
ATOM   1648 C CG2 . THR   A 1 325 ? 117.570 120.040 156.562 1.00 74.15  ? 269 THR   R CG2 1 
ATOM   1649 N N   . PRO   A 1 326 ? 121.360 120.822 156.855 1.00 78.53  ? 270 PRO   R N   1 
ATOM   1650 C CA  . PRO   A 1 326 ? 122.030 121.139 158.129 1.00 78.53  ? 270 PRO   R CA  1 
ATOM   1651 C C   . PRO   A 1 326 ? 122.396 122.607 158.296 1.00 78.53  ? 270 PRO   R C   1 
ATOM   1652 O O   . PRO   A 1 326 ? 122.143 123.186 159.361 1.00 78.53  ? 270 PRO   R O   1 
ATOM   1653 C CB  . PRO   A 1 326 ? 123.277 120.246 158.085 1.00 78.53  ? 270 PRO   R CB  1 
ATOM   1654 C CG  . PRO   A 1 326 ? 122.899 119.122 157.191 1.00 78.53  ? 270 PRO   R CG  1 
ATOM   1655 C CD  . PRO   A 1 326 ? 122.062 119.753 156.126 1.00 78.53  ? 270 PRO   R CD  1 
ATOM   1656 N N   . TYR   A 1 327 ? 122.996 123.227 157.278 1.00 83.04  ? 271 TYR   R N   1 
ATOM   1657 C CA  . TYR   A 1 327 ? 123.430 124.613 157.423 1.00 83.04  ? 271 TYR   R CA  1 
ATOM   1658 C C   . TYR   A 1 327 ? 122.244 125.543 157.631 1.00 83.04  ? 271 TYR   R C   1 
ATOM   1659 O O   . TYR   A 1 327 ? 122.289 126.437 158.483 1.00 83.04  ? 271 TYR   R O   1 
ATOM   1660 C CB  . TYR   A 1 327 ? 124.244 125.041 156.202 1.00 83.04  ? 271 TYR   R CB  1 
ATOM   1661 C CG  . TYR   A 1 327 ? 124.620 126.508 156.187 1.00 83.04  ? 271 TYR   R CG  1 
ATOM   1662 C CD1 . TYR   A 1 327 ? 123.714 127.476 155.778 1.00 83.04  ? 271 TYR   R CD1 1 
ATOM   1663 C CD2 . TYR   A 1 327 ? 125.883 126.925 156.583 1.00 83.04  ? 271 TYR   R CD2 1 
ATOM   1664 C CE1 . TYR   A 1 327 ? 124.054 128.812 155.761 1.00 83.04  ? 271 TYR   R CE1 1 
ATOM   1665 C CE2 . TYR   A 1 327 ? 126.232 128.260 156.569 1.00 83.04  ? 271 TYR   R CE2 1 
ATOM   1666 C CZ  . TYR   A 1 327 ? 125.314 129.198 156.158 1.00 83.04  ? 271 TYR   R CZ  1 
ATOM   1667 O OH  . TYR   A 1 327 ? 125.652 130.531 156.141 1.00 83.04  ? 271 TYR   R OH  1 
ATOM   1668 N N   . HIS   A 1 328 ? 121.172 125.353 156.864 1.00 78.95  ? 272 HIS   R N   1 
ATOM   1669 C CA  . HIS   A 1 328 ? 120.009 126.214 157.021 1.00 78.95  ? 272 HIS   R CA  1 
ATOM   1670 C C   . HIS   A 1 328 ? 119.244 125.904 158.298 1.00 78.95  ? 272 HIS   R C   1 
ATOM   1671 O O   . HIS   A 1 328 ? 118.595 126.797 158.849 1.00 78.95  ? 272 HIS   R O   1 
ATOM   1672 C CB  . HIS   A 1 328 ? 119.110 126.089 155.795 1.00 78.95  ? 272 HIS   R CB  1 
ATOM   1673 C CG  . HIS   A 1 328 ? 119.774 126.530 154.528 1.00 78.95  ? 272 HIS   R CG  1 
ATOM   1674 N ND1 . HIS   A 1 328 ? 120.057 127.852 154.258 1.00 78.95  ? 272 HIS   R ND1 1 
ATOM   1675 C CD2 . HIS   A 1 328 ? 120.241 125.823 153.473 1.00 78.95  ? 272 HIS   R CD2 1 
ATOM   1676 C CE1 . HIS   A 1 328 ? 120.652 127.941 153.083 1.00 78.95  ? 272 HIS   R CE1 1 
ATOM   1677 N NE2 . HIS   A 1 328 ? 120.776 126.724 152.585 1.00 78.95  ? 272 HIS   R NE2 1 
ATOM   1678 N N   . LEU   A 1 329 ? 119.332 124.674 158.801 1.00 82.82  ? 273 LEU   R N   1 
ATOM   1679 C CA  . LEU   A 1 329 ? 118.806 124.374 160.128 1.00 82.82  ? 273 LEU   R CA  1 
ATOM   1680 C C   . LEU   A 1 329 ? 119.567 125.152 161.193 1.00 82.82  ? 273 LEU   R C   1 
ATOM   1681 O O   . LEU   A 1 329 ? 118.970 125.701 162.126 1.00 82.82  ? 273 LEU   R O   1 
ATOM   1682 C CB  . LEU   A 1 329 ? 118.891 122.870 160.390 1.00 82.82  ? 273 LEU   R CB  1 
ATOM   1683 C CG  . LEU   A 1 329 ? 118.446 122.376 161.766 1.00 82.82  ? 273 LEU   R CG  1 
ATOM   1684 C CD1 . LEU   A 1 329 ? 116.949 122.567 161.948 1.00 82.82  ? 273 LEU   R CD1 1 
ATOM   1685 C CD2 . LEU   A 1 329 ? 118.830 120.917 161.948 1.00 82.82  ? 273 LEU   R CD2 1 
ATOM   1686 N N   . VAL   A 1 330 ? 120.891 125.218 161.062 1.00 86.07  ? 274 VAL   R N   1 
ATOM   1687 C CA  . VAL   A 1 330 ? 121.689 126.018 161.987 1.00 86.07  ? 274 VAL   R CA  1 
ATOM   1688 C C   . VAL   A 1 330 ? 121.323 127.491 161.867 1.00 86.07  ? 274 VAL   R C   1 
ATOM   1689 O O   . VAL   A 1 330 ? 121.259 128.218 162.866 1.00 86.07  ? 274 VAL   R O   1 
ATOM   1690 C CB  . VAL   A 1 330 ? 123.188 125.787 161.731 1.00 86.07  ? 274 VAL   R CB  1 
ATOM   1691 C CG1 . VAL   A 1 330 ? 124.019 126.800 162.499 1.00 86.07  ? 274 VAL   R CG1 1 
ATOM   1692 C CG2 . VAL   A 1 330 ? 123.573 124.370 162.112 1.00 86.07  ? 274 VAL   R CG2 1 
ATOM   1693 N N   . VAL   A 1 331 ? 121.099 127.961 160.640 1.00 84.32  ? 275 VAL   R N   1 
ATOM   1694 C CA  . VAL   A 1 331 ? 120.712 129.353 160.437 1.00 84.32  ? 275 VAL   R CA  1 
ATOM   1695 C C   . VAL   A 1 331 ? 119.374 129.636 161.109 1.00 84.32  ? 275 VAL   R C   1 
ATOM   1696 O O   . VAL   A 1 331 ? 119.190 130.684 161.738 1.00 84.32  ? 275 VAL   R O   1 
ATOM   1697 C CB  . VAL   A 1 331 ? 120.672 129.683 158.934 1.00 84.32  ? 275 VAL   R CB  1 
ATOM   1698 C CG1 . VAL   A 1 331 ? 119.883 130.958 158.688 1.00 84.32  ? 275 VAL   R CG1 1 
ATOM   1699 C CG2 . VAL   A 1 331 ? 122.083 129.817 158.385 1.00 84.32  ? 275 VAL   R CG2 1 
ATOM   1700 N N   . LEU   A 1 332 ? 118.416 128.719 160.977 1.00 86.59  ? 276 LEU   R N   1 
ATOM   1701 C CA  . LEU   A 1 332 ? 117.138 128.883 161.661 1.00 86.59  ? 276 LEU   R CA  1 
ATOM   1702 C C   . LEU   A 1 332 ? 117.320 128.863 163.172 1.00 86.59  ? 276 LEU   R C   1 
ATOM   1703 O O   . LEU   A 1 332 ? 116.629 129.587 163.894 1.00 86.59  ? 276 LEU   R O   1 
ATOM   1704 C CB  . LEU   A 1 332 ? 116.161 127.791 161.229 1.00 86.59  ? 276 LEU   R CB  1 
ATOM   1705 C CG  . LEU   A 1 332 ? 114.708 128.014 161.657 1.00 86.59  ? 276 LEU   R CG  1 
ATOM   1706 C CD1 . LEU   A 1 332 ? 113.998 128.951 160.699 1.00 86.59  ? 276 LEU   R CD1 1 
ATOM   1707 C CD2 . LEU   A 1 332 ? 113.970 126.690 161.753 1.00 86.59  ? 276 LEU   R CD2 1 
ATOM   1708 N N   . VAL   A 1 333 ? 118.237 128.032 163.670 1.00 90.13  ? 277 VAL   R N   1 
ATOM   1709 C CA  . VAL   A 1 333 ? 118.516 128.006 165.104 1.00 90.13  ? 277 VAL   R CA  1 
ATOM   1710 C C   . VAL   A 1 333 ? 119.021 129.368 165.560 1.00 90.13  ? 277 VAL   R C   1 
ATOM   1711 O O   . VAL   A 1 333 ? 118.609 129.892 166.602 1.00 90.13  ? 277 VAL   R O   1 
ATOM   1712 C CB  . VAL   A 1 333 ? 119.527 126.893 165.432 1.00 90.13  ? 277 VAL   R CB  1 
ATOM   1713 C CG1 . VAL   A 1 333 ? 120.117 127.098 166.818 1.00 90.13  ? 277 VAL   R CG1 1 
ATOM   1714 C CG2 . VAL   A 1 333 ? 118.865 125.530 165.330 1.00 90.13  ? 277 VAL   R CG2 1 
ATOM   1715 N N   . ASP   A 1 334 ? 119.932 129.956 164.786 1.00 92.49  ? 278 ASP   R N   1 
ATOM   1716 C CA  . ASP   A 1 334 ? 120.456 131.278 165.119 1.00 92.49  ? 278 ASP   R CA  1 
ATOM   1717 C C   . ASP   A 1 334 ? 119.352 132.330 165.073 1.00 92.49  ? 278 ASP   R C   1 
ATOM   1718 O O   . ASP   A 1 334 ? 119.270 133.209 165.939 1.00 92.49  ? 278 ASP   R O   1 
ATOM   1719 C CB  . ASP   A 1 334 ? 121.590 131.644 164.163 1.00 92.49  ? 278 ASP   R CB  1 
ATOM   1720 C CG  . ASP   A 1 334 ? 122.286 132.930 164.554 1.00 92.49  ? 278 ASP   R CG  1 
ATOM   1721 O OD1 . ASP   A 1 334 ? 122.802 133.005 165.689 1.00 92.49  ? 278 ASP   R OD1 1 
ATOM   1722 O OD2 . ASP   A 1 334 ? 122.317 133.865 163.728 1.00 92.49  ? 278 ASP   R OD2 1 
ATOM   1723 N N   . ILE   A 1 335 ? 118.491 132.256 164.057 1.00 88.79  ? 279 ILE   R N   1 
ATOM   1724 C CA  . ILE   A 1 335 ? 117.382 133.201 163.957 1.00 88.79  ? 279 ILE   R CA  1 
ATOM   1725 C C   . ILE   A 1 335 ? 116.488 133.087 165.182 1.00 88.79  ? 279 ILE   R C   1 
ATOM   1726 O O   . ILE   A 1 335 ? 116.069 134.094 165.761 1.00 88.79  ? 279 ILE   R O   1 
ATOM   1727 C CB  . ILE   A 1 335 ? 116.591 132.961 162.658 1.00 88.79  ? 279 ILE   R CB  1 
ATOM   1728 C CG1 . ILE   A 1 335 ? 117.389 133.470 161.456 1.00 88.79  ? 279 ILE   R CG1 1 
ATOM   1729 C CG2 . ILE   A 1 335 ? 115.218 133.631 162.743 1.00 88.79  ? 279 ILE   R CG2 1 
ATOM   1730 C CD1 . ILE   A 1 335 ? 116.675 133.319 160.130 1.00 88.79  ? 279 ILE   R CD1 1 
ATOM   1731 N N   . LEU   A 1 336 ? 116.178 131.857 165.592 1.00 94.20  ? 280 LEU   R N   1 
ATOM   1732 C CA  . LEU   A 1 336 ? 115.339 131.656 166.768 1.00 94.20  ? 280 LEU   R CA  1 
ATOM   1733 C C   . LEU   A 1 336 ? 116.012 132.200 168.021 1.00 94.20  ? 280 LEU   R C   1 
ATOM   1734 O O   . LEU   A 1 336 ? 115.365 132.851 168.850 1.00 94.20  ? 280 LEU   R O   1 
ATOM   1735 C CB  . LEU   A 1 336 ? 115.021 130.172 166.933 1.00 94.20  ? 280 LEU   R CB  1 
ATOM   1736 C CG  . LEU   A 1 336 ? 114.212 129.546 165.797 1.00 94.20  ? 280 LEU   R CG  1 
ATOM   1737 C CD1 . LEU   A 1 336 ? 114.469 128.049 165.726 1.00 94.20  ? 280 LEU   R CD1 1 
ATOM   1738 C CD2 . LEU   A 1 336 ? 112.729 129.830 165.975 1.00 94.20  ? 280 LEU   R CD2 1 
ATOM   1739 N N   . MET   A 1 337 ? 117.310 131.945 168.177 1.00 100.04 ? 281 MET   R N   1 
ATOM   1740 C CA  . MET   A 1 337 ? 118.049 132.477 169.315 1.00 100.04 ? 281 MET   R CA  1 
ATOM   1741 C C   . MET   A 1 337 ? 118.093 133.997 169.319 1.00 100.04 ? 281 MET   R C   1 
ATOM   1742 O O   . MET   A 1 337 ? 118.228 134.592 170.394 1.00 100.04 ? 281 MET   R O   1 
ATOM   1743 C CB  . MET   A 1 337 ? 119.474 131.920 169.318 1.00 100.04 ? 281 MET   R CB  1 
ATOM   1744 C CG  . MET   A 1 337 ? 119.599 130.561 169.990 1.00 100.04 ? 281 MET   R CG  1 
ATOM   1745 S SD  . MET   A 1 337 ? 121.294 129.946 170.033 1.00 100.04 ? 281 MET   R SD  1 
ATOM   1746 C CE  . MET   A 1 337 ? 121.802 130.466 171.669 1.00 100.04 ? 281 MET   R CE  1 
ATOM   1747 N N   . ASP   A 1 338 ? 117.990 134.632 168.150 1.00 97.41  ? 282 ASP   R N   1 
ATOM   1748 C CA  . ASP   A 1 338 ? 117.891 136.081 168.063 1.00 97.41  ? 282 ASP   R CA  1 
ATOM   1749 C C   . ASP   A 1 338 ? 116.461 136.600 168.108 1.00 97.41  ? 282 ASP   R C   1 
ATOM   1750 O O   . ASP   A 1 338 ? 116.269 137.817 168.206 1.00 97.41  ? 282 ASP   R O   1 
ATOM   1751 C CB  . ASP   A 1 338 ? 118.559 136.587 166.774 1.00 97.41  ? 282 ASP   R CB  1 
ATOM   1752 C CG  . ASP   A 1 338 ? 120.017 136.182 166.673 1.00 97.41  ? 282 ASP   R CG  1 
ATOM   1753 O OD1 . ASP   A 1 338 ? 120.511 135.504 167.597 1.00 97.41  ? 282 ASP   R OD1 1 
ATOM   1754 O OD2 . ASP   A 1 338 ? 120.668 136.543 165.670 1.00 97.41  ? 282 ASP   R OD2 1 
ATOM   1755 N N   . LEU   A 1 339 ? 115.460 135.725 168.040 1.00 93.01  ? 283 LEU   R N   1 
ATOM   1756 C CA  . LEU   A 1 339 ? 114.059 136.124 168.049 1.00 93.01  ? 283 LEU   R CA  1 
ATOM   1757 C C   . LEU   A 1 339 ? 113.399 135.954 169.410 1.00 93.01  ? 283 LEU   R C   1 
ATOM   1758 O O   . LEU   A 1 339 ? 112.196 136.200 169.534 1.00 93.01  ? 283 LEU   R O   1 
ATOM   1759 C CB  . LEU   A 1 339 ? 113.280 135.322 167.002 1.00 93.01  ? 283 LEU   R CB  1 
ATOM   1760 C CG  . LEU   A 1 339 ? 113.473 135.731 165.541 1.00 93.01  ? 283 LEU   R CG  1 
ATOM   1761 C CD1 . LEU   A 1 339 ? 112.742 134.767 164.624 1.00 93.01  ? 283 LEU   R CD1 1 
ATOM   1762 C CD2 . LEU   A 1 339 ? 112.994 137.155 165.307 1.00 93.01  ? 283 LEU   R CD2 1 
ATOM   1763 N N   . GLY   A 1 340 ? 114.148 135.542 170.427 1.00 95.58  ? 284 GLY   R N   1 
ATOM   1764 C CA  . GLY   A 1 340 ? 113.597 135.356 171.752 1.00 95.58  ? 284 GLY   R CA  1 
ATOM   1765 C C   . GLY   A 1 340 ? 112.969 134.005 172.004 1.00 95.58  ? 284 GLY   R C   1 
ATOM   1766 O O   . GLY   A 1 340 ? 112.562 133.734 173.140 1.00 95.58  ? 284 GLY   R O   1 
ATOM   1767 N N   . ALA   A 1 341 ? 112.876 133.147 170.989 1.00 98.09  ? 285 ALA   R N   1 
ATOM   1768 C CA  . ALA   A 1 341 ? 112.318 131.815 171.167 1.00 98.09  ? 285 ALA   R CA  1 
ATOM   1769 C C   . ALA   A 1 341 ? 113.259 130.872 171.899 1.00 98.09  ? 285 ALA   R C   1 
ATOM   1770 O O   . ALA   A 1 341 ? 112.792 129.900 172.503 1.00 98.09  ? 285 ALA   R O   1 
ATOM   1771 C CB  . ALA   A 1 341 ? 111.958 131.206 169.809 1.00 98.09  ? 285 ALA   R CB  1 
ATOM   1772 N N   . LEU   A 1 342 ? 114.562 131.134 171.863 1.00 100.28 ? 286 LEU   R N   1 
ATOM   1773 C CA  . LEU   A 1 342 ? 115.556 130.291 172.506 1.00 100.28 ? 286 LEU   R CA  1 
ATOM   1774 C C   . LEU   A 1 342 ? 116.439 131.154 173.396 1.00 100.28 ? 286 LEU   R C   1 
ATOM   1775 O O   . LEU   A 1 342 ? 116.602 132.356 173.173 1.00 100.28 ? 286 LEU   R O   1 
ATOM   1776 C CB  . LEU   A 1 342 ? 116.403 129.543 171.469 1.00 100.28 ? 286 LEU   R CB  1 
ATOM   1777 C CG  . LEU   A 1 342 ? 115.665 128.463 170.673 1.00 100.28 ? 286 LEU   R CG  1 
ATOM   1778 C CD1 . LEU   A 1 342 ? 116.557 127.897 169.580 1.00 100.28 ? 286 LEU   R CD1 1 
ATOM   1779 C CD2 . LEU   A 1 342 ? 115.175 127.354 171.590 1.00 100.28 ? 286 LEU   R CD2 1 
ATOM   1780 N N   . ALA   A 1 343 ? 117.014 130.524 174.414 1.00 103.63 ? 287 ALA   R N   1 
ATOM   1781 C CA  . ALA   A 1 343 ? 117.806 131.217 175.418 1.00 103.63 ? 287 ALA   R CA  1 
ATOM   1782 C C   . ALA   A 1 343 ? 119.277 131.206 175.029 1.00 103.63 ? 287 ALA   R C   1 
ATOM   1783 O O   . ALA   A 1 343 ? 119.811 130.179 174.603 1.00 103.63 ? 287 ALA   R O   1 
ATOM   1784 C CB  . ALA   A 1 343 ? 117.626 130.571 176.793 1.00 103.63 ? 287 ALA   R CB  1 
ATOM   1785 N N   . ARG   A 1 344 ? 119.926 132.359 175.174 1.00 103.26 ? 288 ARG   R N   1 
ATOM   1786 C CA  . ARG   A 1 344 ? 121.346 132.479 174.873 1.00 103.26 ? 288 ARG   R CA  1 
ATOM   1787 C C   . ARG   A 1 344 ? 122.178 132.071 176.081 1.00 103.26 ? 288 ARG   R C   1 
ATOM   1788 O O   . ARG   A 1 344 ? 121.905 132.496 177.208 1.00 103.26 ? 288 ARG   R O   1 
ATOM   1789 C CB  . ARG   A 1 344 ? 121.690 133.911 174.467 1.00 103.26 ? 288 ARG   R CB  1 
ATOM   1790 C CG  . ARG   A 1 344 ? 121.303 134.278 173.047 1.00 103.26 ? 288 ARG   R CG  1 
ATOM   1791 C CD  . ARG   A 1 344 ? 121.671 135.722 172.749 1.00 103.26 ? 288 ARG   R CD  1 
ATOM   1792 N NE  . ARG   A 1 344 ? 121.568 136.041 171.329 1.00 103.26 ? 288 ARG   R NE  1 
ATOM   1793 C CZ  . ARG   A 1 344 ? 120.683 136.874 170.794 1.00 103.26 ? 288 ARG   R CZ  1 
ATOM   1794 N NH1 . ARG   A 1 344 ? 119.760 137.476 171.528 1.00 103.26 ? 288 ARG   R NH1 1 
ATOM   1795 N NH2 . ARG   A 1 344 ? 120.724 137.109 169.486 1.00 103.26 ? 288 ARG   R NH2 1 
ATOM   1796 N N   . ASN   A 1 345 ? 123.193 131.245 175.841 1.00 107.74 ? 289 ASN   R N   1 
ATOM   1797 C CA  . ASN   A 1 345 ? 124.139 130.863 176.878 1.00 107.74 ? 289 ASN   R CA  1 
ATOM   1798 C C   . ASN   A 1 345 ? 125.430 130.410 176.215 1.00 107.74 ? 289 ASN   R C   1 
ATOM   1799 O O   . ASN   A 1 345 ? 125.463 130.130 175.013 1.00 107.74 ? 289 ASN   R O   1 
ATOM   1800 C CB  . ASN   A 1 345 ? 123.578 129.759 177.783 1.00 107.74 ? 289 ASN   R CB  1 
ATOM   1801 C CG  . ASN   A 1 345 ? 123.135 128.539 177.007 1.00 107.74 ? 289 ASN   R CG  1 
ATOM   1802 O OD1 . ASN   A 1 345 ? 123.922 127.627 176.757 1.00 107.74 ? 289 ASN   R OD1 1 
ATOM   1803 N ND2 . ASN   A 1 345 ? 121.865 128.515 176.622 1.00 107.74 ? 289 ASN   R ND2 1 
ATOM   1804 N N   . CYS   A 1 346 ? 126.497 130.344 177.013 1.00 110.46 ? 290 CYS   R N   1 
ATOM   1805 C CA  . CYS   A 1 346 ? 127.818 130.025 176.488 1.00 110.46 ? 290 CYS   R CA  1 
ATOM   1806 C C   . CYS   A 1 346 ? 127.830 128.682 175.764 1.00 110.46 ? 290 CYS   R C   1 
ATOM   1807 O O   . CYS   A 1 346 ? 128.325 128.572 174.636 1.00 110.46 ? 290 CYS   R O   1 
ATOM   1808 C CB  . CYS   A 1 346 ? 128.835 130.025 177.633 1.00 110.46 ? 290 CYS   R CB  1 
ATOM   1809 S SG  . CYS   A 1 346 ? 128.559 131.320 178.865 1.00 110.46 ? 290 CYS   R SG  1 
ATOM   1810 N N   . GLY   A 1 347 ? 127.284 127.648 176.406 1.00 109.91 ? 291 GLY   R N   1 
ATOM   1811 C CA  . GLY   A 1 347 ? 127.299 126.326 175.799 1.00 109.91 ? 291 GLY   R CA  1 
ATOM   1812 C C   . GLY   A 1 347 ? 126.486 126.264 174.520 1.00 109.91 ? 291 GLY   R C   1 
ATOM   1813 O O   . GLY   A 1 347 ? 126.921 125.691 173.517 1.00 109.91 ? 291 GLY   R O   1 
ATOM   1814 N N   . ARG   A 1 348 ? 125.287 126.850 174.540 1.00 105.44 ? 292 ARG   R N   1 
ATOM   1815 C CA  . ARG   A 1 348 ? 124.454 126.851 173.344 1.00 105.44 ? 292 ARG   R CA  1 
ATOM   1816 C C   . ARG   A 1 348 ? 125.142 127.587 172.203 1.00 105.44 ? 292 ARG   R C   1 
ATOM   1817 O O   . ARG   A 1 348 ? 125.135 127.121 171.058 1.00 105.44 ? 292 ARG   R O   1 
ATOM   1818 C CB  . ARG   A 1 348 ? 123.100 127.486 173.655 1.00 105.44 ? 292 ARG   R CB  1 
ATOM   1819 C CG  . ARG   A 1 348 ? 121.958 126.965 172.801 1.00 105.44 ? 292 ARG   R CG  1 
ATOM   1820 C CD  . ARG   A 1 348 ? 121.176 125.884 173.531 1.00 105.44 ? 292 ARG   R CD  1 
ATOM   1821 N NE  . ARG   A 1 348 ? 120.065 126.430 174.301 1.00 105.44 ? 292 ARG   R NE  1 
ATOM   1822 C CZ  . ARG   A 1 348 ? 118.951 126.918 173.772 1.00 105.44 ? 292 ARG   R CZ  1 
ATOM   1823 N NH1 . ARG   A 1 348 ? 118.755 126.934 172.463 1.00 105.44 ? 292 ARG   R NH1 1 
ATOM   1824 N NH2 . ARG   A 1 348 ? 118.008 127.400 174.577 1.00 105.44 ? 292 ARG   R NH2 1 
ATOM   1825 N N   . GLU   A 1 349 ? 125.747 128.737 172.497 1.00 106.99 ? 293 GLU   R N   1 
ATOM   1826 C CA  . GLU   A 1 349 ? 126.422 129.507 171.459 1.00 106.99 ? 293 GLU   R CA  1 
ATOM   1827 C C   . GLU   A 1 349 ? 127.614 128.737 170.898 1.00 106.99 ? 293 GLU   R C   1 
ATOM   1828 O O   . GLU   A 1 349 ? 127.847 128.724 169.682 1.00 106.99 ? 293 GLU   R O   1 
ATOM   1829 C CB  . GLU   A 1 349 ? 126.852 130.859 172.029 1.00 106.99 ? 293 GLU   R CB  1 
ATOM   1830 C CG  . GLU   A 1 349 ? 127.666 131.726 171.089 1.00 106.99 ? 293 GLU   R CG  1 
ATOM   1831 C CD  . GLU   A 1 349 ? 128.107 133.018 171.745 1.00 106.99 ? 293 GLU   R CD  1 
ATOM   1832 O OE1 . GLU   A 1 349 ? 127.231 133.830 172.108 1.00 106.99 ? 293 GLU   R OE1 1 
ATOM   1833 O OE2 . GLU   A 1 349 ? 129.329 133.219 171.906 1.00 106.99 ? 293 GLU   R OE2 1 
ATOM   1834 N N   . SER   A 1 350 ? 128.381 128.083 171.772 1.00 103.76 ? 294 SER   R N   1 
ATOM   1835 C CA  . SER   A 1 350 ? 129.500 127.276 171.299 1.00 103.76 ? 294 SER   R CA  1 
ATOM   1836 C C   . SER   A 1 350 ? 129.023 126.138 170.407 1.00 103.76 ? 294 SER   R C   1 
ATOM   1837 O O   . SER   A 1 350 ? 129.634 125.862 169.366 1.00 103.76 ? 294 SER   R O   1 
ATOM   1838 C CB  . SER   A 1 350 ? 130.288 126.722 172.487 1.00 103.76 ? 294 SER   R CB  1 
ATOM   1839 O OG  . SER   A 1 350 ? 130.734 127.765 173.336 1.00 103.76 ? 294 SER   R OG  1 
ATOM   1840 N N   . ARG   A 1 351 ? 127.938 125.467 170.797 1.00 102.82 ? 295 ARG   R N   1 
ATOM   1841 C CA  . ARG   A 1 351 ? 127.405 124.392 169.969 1.00 102.82 ? 295 ARG   R CA  1 
ATOM   1842 C C   . ARG   A 1 351 ? 126.941 124.926 168.621 1.00 102.82 ? 295 ARG   R C   1 
ATOM   1843 O O   . ARG   A 1 351 ? 127.147 124.282 167.585 1.00 102.82 ? 295 ARG   R O   1 
ATOM   1844 C CB  . ARG   A 1 351 ? 126.262 123.688 170.700 1.00 102.82 ? 295 ARG   R CB  1 
ATOM   1845 C CG  . ARG   A 1 351 ? 126.733 122.815 171.858 1.00 102.82 ? 295 ARG   R CG  1 
ATOM   1846 C CD  . ARG   A 1 351 ? 125.774 122.843 173.042 1.00 102.82 ? 295 ARG   R CD  1 
ATOM   1847 N NE  . ARG   A 1 351 ? 124.701 121.864 172.896 1.00 102.82 ? 295 ARG   R NE  1 
ATOM   1848 C CZ  . ARG   A 1 351 ? 123.407 122.149 172.812 1.00 102.82 ? 295 ARG   R CZ  1 
ATOM   1849 N NH1 . ARG   A 1 351 ? 122.961 123.395 172.865 1.00 102.82 ? 295 ARG   R NH1 1 
ATOM   1850 N NH2 . ARG   A 1 351 ? 122.533 121.156 172.675 1.00 102.82 ? 295 ARG   R NH2 1 
ATOM   1851 N N   . VAL   A 1 352 ? 126.316 126.105 168.613 1.00 96.23  ? 296 VAL   R N   1 
ATOM   1852 C CA  . VAL   A 1 352 ? 125.907 126.716 167.353 1.00 96.23  ? 296 VAL   R CA  1 
ATOM   1853 C C   . VAL   A 1 352 ? 127.117 126.986 166.474 1.00 96.23  ? 296 VAL   R C   1 
ATOM   1854 O O   . VAL   A 1 352 ? 127.073 126.765 165.260 1.00 96.23  ? 296 VAL   R O   1 
ATOM   1855 C CB  . VAL   A 1 352 ? 125.103 128.004 167.620 1.00 96.23  ? 296 VAL   R CB  1 
ATOM   1856 C CG1 . VAL   A 1 352 ? 124.886 128.773 166.329 1.00 96.23  ? 296 VAL   R CG1 1 
ATOM   1857 C CG2 . VAL   A 1 352 ? 123.768 127.670 168.265 1.00 96.23  ? 296 VAL   R CG2 1 
ATOM   1858 N N   . ASP   A 1 353 ? 128.210 127.475 167.060 1.00 94.83  ? 297 ASP   R N   1 
ATOM   1859 C CA  . ASP   A 1 353 ? 129.419 127.727 166.279 1.00 94.83  ? 297 ASP   R CA  1 
ATOM   1860 C C   . ASP   A 1 353 ? 129.978 126.434 165.690 1.00 94.83  ? 297 ASP   R C   1 
ATOM   1861 O O   . ASP   A 1 353 ? 130.385 126.392 164.518 1.00 94.83  ? 297 ASP   R O   1 
ATOM   1862 C CB  . ASP   A 1 353 ? 130.468 128.416 167.152 1.00 94.83  ? 297 ASP   R CB  1 
ATOM   1863 C CG  . ASP   A 1 353 ? 131.473 129.207 166.341 1.00 94.83  ? 297 ASP   R CG  1 
ATOM   1864 O OD1 . ASP   A 1 353 ? 131.046 130.059 165.533 1.00 94.83  ? 297 ASP   R OD1 1 
ATOM   1865 O OD2 . ASP   A 1 353 ? 132.689 128.979 166.511 1.00 94.83  ? 297 ASP   R OD2 1 
ATOM   1866 N N   . VAL   A 1 354 ? 130.009 125.369 166.493 1.00 92.11  ? 298 VAL   R N   1 
ATOM   1867 C CA  . VAL   A 1 354 ? 130.508 124.086 166.000 1.00 92.11  ? 298 VAL   R CA  1 
ATOM   1868 C C   . VAL   A 1 354 ? 129.647 123.604 164.839 1.00 92.11  ? 298 VAL   R C   1 
ATOM   1869 O O   . VAL   A 1 354 ? 130.152 123.109 163.820 1.00 92.11  ? 298 VAL   R O   1 
ATOM   1870 C CB  . VAL   A 1 354 ? 130.549 123.050 167.138 1.00 92.11  ? 298 VAL   R CB  1 
ATOM   1871 C CG1 . VAL   A 1 354 ? 131.177 121.753 166.654 1.00 92.11  ? 298 VAL   R CG1 1 
ATOM   1872 C CG2 . VAL   A 1 354 ? 131.314 123.596 168.334 1.00 92.11  ? 298 VAL   R CG2 1 
ATOM   1873 N N   . ALA   A 1 355 ? 128.330 123.734 164.985 1.00 89.42  ? 299 ALA   R N   1 
ATOM   1874 C CA  . ALA   A 1 355 ? 127.401 123.332 163.939 1.00 89.42  ? 299 ALA   R CA  1 
ATOM   1875 C C   . ALA   A 1 355 ? 127.653 124.144 162.678 1.00 89.42  ? 299 ALA   R C   1 
ATOM   1876 O O   . ALA   A 1 355 ? 127.650 123.595 161.574 1.00 89.42  ? 299 ALA   R O   1 
ATOM   1877 C CB  . ALA   A 1 355 ? 125.957 123.505 164.410 1.00 89.42  ? 299 ALA   R CB  1 
ATOM   1878 N N   . LYS   A 1 356 ? 127.864 125.452 162.830 1.00 87.51  ? 300 LYS   R N   1 
ATOM   1879 C CA  . LYS   A 1 356 ? 128.197 126.301 161.695 1.00 87.51  ? 300 LYS   R CA  1 
ATOM   1880 C C   . LYS   A 1 356 ? 129.399 125.750 160.943 1.00 87.51  ? 300 LYS   R C   1 
ATOM   1881 O O   . LYS   A 1 356 ? 129.362 125.565 159.720 1.00 87.51  ? 300 LYS   R O   1 
ATOM   1882 C CB  . LYS   A 1 356 ? 128.486 127.728 162.174 1.00 87.51  ? 300 LYS   R CB  1 
ATOM   1883 C CG  . LYS   A 1 356 ? 127.261 128.581 162.437 1.00 87.51  ? 300 LYS   R CG  1 
ATOM   1884 C CD  . LYS   A 1 356 ? 126.718 129.180 161.148 1.00 87.51  ? 300 LYS   R CD  1 
ATOM   1885 C CE  . LYS   A 1 356 ? 125.652 130.233 161.412 1.00 87.51  ? 300 LYS   R CE  1 
ATOM   1886 N NZ  . LYS   A 1 356 ? 126.073 131.244 162.422 1.00 87.51  ? 300 LYS   R NZ  1 
ATOM   1887 N N   . SER   A 1 357 ? 130.481 125.482 161.675 1.00 86.55  ? 301 SER   R N   1 
ATOM   1888 C CA  . SER   A 1 357 ? 131.708 125.017 161.035 1.00 86.55  ? 301 SER   R CA  1 
ATOM   1889 C C   . SER   A 1 357 ? 131.472 123.713 160.278 1.00 86.55  ? 301 SER   R C   1 
ATOM   1890 O O   . SER   A 1 357 ? 131.804 123.588 159.089 1.00 86.55  ? 301 SER   R O   1 
ATOM   1891 C CB  . SER   A 1 357 ? 132.805 124.839 162.085 1.00 86.55  ? 301 SER   R CB  1 
ATOM   1892 O OG  . SER   A 1 357 ? 132.719 125.836 163.088 1.00 86.55  ? 301 SER   R OG  1 
ATOM   1893 N N   . VAL   A 1 358 ? 130.885 122.725 160.957 1.00 86.04  ? 302 VAL   R N   1 
ATOM   1894 C CA  . VAL   A 1 358 ? 130.726 121.408 160.343 1.00 86.04  ? 302 VAL   R CA  1 
ATOM   1895 C C   . VAL   A 1 358 ? 129.786 121.483 159.146 1.00 86.04  ? 302 VAL   R C   1 
ATOM   1896 O O   . VAL   A 1 358 ? 130.022 120.848 158.110 1.00 86.04  ? 302 VAL   R O   1 
ATOM   1897 C CB  . VAL   A 1 358 ? 130.243 120.385 161.387 1.00 86.04  ? 302 VAL   R CB  1 
ATOM   1898 C CG1 . VAL   A 1 358 ? 130.097 119.014 160.753 1.00 86.04  ? 302 VAL   R CG1 1 
ATOM   1899 C CG2 . VAL   A 1 358 ? 131.218 120.320 162.553 1.00 86.04  ? 302 VAL   R CG2 1 
ATOM   1900 N N   . THR   A 1 359 ? 128.704 122.254 159.265 1.00 84.51  ? 303 THR   R N   1 
ATOM   1901 C CA  . THR   A 1 359 ? 127.750 122.360 158.169 1.00 84.51  ? 303 THR   R CA  1 
ATOM   1902 C C   . THR   A 1 359 ? 128.367 123.064 156.968 1.00 84.51  ? 303 THR   R C   1 
ATOM   1903 O O   . THR   A 1 359 ? 128.085 122.702 155.821 1.00 84.51  ? 303 THR   R O   1 
ATOM   1904 C CB  . THR   A 1 359 ? 126.499 123.094 158.642 1.00 84.51  ? 303 THR   R CB  1 
ATOM   1905 O OG1 . THR   A 1 359 ? 126.880 124.253 159.391 1.00 84.51  ? 303 THR   R OG1 1 
ATOM   1906 C CG2 . THR   A 1 359 ? 125.661 122.187 159.528 1.00 84.51  ? 303 THR   R CG2 1 
ATOM   1907 N N   . SER   A 1 360 ? 129.207 124.075 157.203 1.00 86.40  ? 304 SER   R N   1 
ATOM   1908 C CA  . SER   A 1 360 ? 129.913 124.701 156.091 1.00 86.40  ? 304 SER   R CA  1 
ATOM   1909 C C   . SER   A 1 360 ? 130.840 123.704 155.409 1.00 86.40  ? 304 SER   R C   1 
ATOM   1910 O O   . SER   A 1 360 ? 130.953 123.684 154.174 1.00 86.40  ? 304 SER   R O   1 
ATOM   1911 C CB  . SER   A 1 360 ? 130.695 125.917 156.585 1.00 86.40  ? 304 SER   R CB  1 
ATOM   1912 O OG  . SER   A 1 360 ? 129.820 126.958 156.981 1.00 86.40  ? 304 SER   R OG  1 
ATOM   1913 N N   . GLY   A 1 361 ? 131.519 122.872 156.195 1.00 84.78  ? 305 GLY   R N   1 
ATOM   1914 C CA  . GLY   A 1 361 ? 132.340 121.824 155.617 1.00 84.78  ? 305 GLY   R CA  1 
ATOM   1915 C C   . GLY   A 1 361 ? 131.531 120.902 154.724 1.00 84.78  ? 305 GLY   R C   1 
ATOM   1916 O O   . GLY   A 1 361 ? 131.945 120.564 153.608 1.00 84.78  ? 305 GLY   R O   1 
ATOM   1917 N N   . LEU   A 1 362 ? 130.358 120.495 155.213 1.00 82.48  ? 306 LEU   R N   1 
ATOM   1918 C CA  . LEU   A 1 362 ? 129.484 119.635 154.418 1.00 82.48  ? 306 LEU   R CA  1 
ATOM   1919 C C   . LEU   A 1 362 ? 129.037 120.332 153.138 1.00 82.48  ? 306 LEU   R C   1 
ATOM   1920 O O   . LEU   A 1 362 ? 128.940 119.706 152.075 1.00 82.48  ? 306 LEU   R O   1 
ATOM   1921 C CB  . LEU   A 1 362 ? 128.269 119.211 155.243 1.00 82.48  ? 306 LEU   R CB  1 
ATOM   1922 C CG  . LEU   A 1 362 ? 128.221 117.735 155.641 1.00 82.48  ? 306 LEU   R CG  1 
ATOM   1923 C CD1 . LEU   A 1 362 ? 129.389 117.376 156.544 1.00 82.48  ? 306 LEU   R CD1 1 
ATOM   1924 C CD2 . LEU   A 1 362 ? 126.903 117.416 156.320 1.00 82.48  ? 306 LEU   R CD2 1 
ATOM   1925 N N   . GLY   A 1 363 ? 128.738 121.627 153.227 1.00 83.56  ? 307 GLY   R N   1 
ATOM   1926 C CA  . GLY   A 1 363 ? 128.342 122.363 152.038 1.00 83.56  ? 307 GLY   R CA  1 
ATOM   1927 C C   . GLY   A 1 363 ? 129.436 122.384 150.988 1.00 83.56  ? 307 GLY   R C   1 
ATOM   1928 O O   . GLY   A 1 363 ? 129.178 122.187 149.796 1.00 83.56  ? 307 GLY   R O   1 
ATOM   1929 N N   . TYR   A 1 364 ? 130.676 122.628 151.415 1.00 83.94  ? 308 TYR   R N   1 
ATOM   1930 C CA  . TYR   A 1 364 ? 131.785 122.573 150.468 1.00 83.94  ? 308 TYR   R CA  1 
ATOM   1931 C C   . TYR   A 1 364 ? 131.955 121.174 149.895 1.00 83.94  ? 308 TYR   R C   1 
ATOM   1932 O O   . TYR   A 1 364 ? 132.298 121.018 148.716 1.00 83.94  ? 308 TYR   R O   1 
ATOM   1933 C CB  . TYR   A 1 364 ? 133.080 123.034 151.133 1.00 83.94  ? 308 TYR   R CB  1 
ATOM   1934 C CG  . TYR   A 1 364 ? 133.317 124.520 151.012 1.00 83.94  ? 308 TYR   R CG  1 
ATOM   1935 C CD1 . TYR   A 1 364 ? 132.531 125.428 151.703 1.00 83.94  ? 308 TYR   R CD1 1 
ATOM   1936 C CD2 . TYR   A 1 364 ? 134.318 125.013 150.191 1.00 83.94  ? 308 TYR   R CD2 1 
ATOM   1937 C CE1 . TYR   A 1 364 ? 132.745 126.785 151.589 1.00 83.94  ? 308 TYR   R CE1 1 
ATOM   1938 C CE2 . TYR   A 1 364 ? 134.538 126.368 150.070 1.00 83.94  ? 308 TYR   R CE2 1 
ATOM   1939 C CZ  . TYR   A 1 364 ? 133.750 127.248 150.770 1.00 83.94  ? 308 TYR   R CZ  1 
ATOM   1940 O OH  . TYR   A 1 364 ? 133.969 128.599 150.649 1.00 83.94  ? 308 TYR   R OH  1 
ATOM   1941 N N   . MET   A 1 365 ? 131.719 120.143 150.708 1.00 83.00  ? 309 MET   R N   1 
ATOM   1942 C CA  . MET   A 1 365 ? 131.756 118.778 150.192 1.00 83.00  ? 309 MET   R CA  1 
ATOM   1943 C C   . MET   A 1 365 ? 130.741 118.601 149.070 1.00 83.00  ? 309 MET   R C   1 
ATOM   1944 O O   . MET   A 1 365 ? 131.038 118.008 148.027 1.00 83.00  ? 309 MET   R O   1 
ATOM   1945 C CB  . MET   A 1 365 ? 131.490 117.780 151.321 1.00 83.00  ? 309 MET   R CB  1 
ATOM   1946 C CG  . MET   A 1 365 ? 132.261 116.477 151.186 1.00 83.00  ? 309 MET   R CG  1 
ATOM   1947 S SD  . MET   A 1 365 ? 132.423 115.591 152.748 1.00 83.00  ? 309 MET   R SD  1 
ATOM   1948 C CE  . MET   A 1 365 ? 130.924 114.611 152.738 1.00 83.00  ? 309 MET   R CE  1 
ATOM   1949 N N   . HIS   A 1 366 ? 129.527 119.114 149.271 1.00 75.78  ? 310 HIS   R N   1 
ATOM   1950 C CA  . HIS   A 1 366 ? 128.514 119.036 148.221 1.00 75.78  ? 310 HIS   R CA  1 
ATOM   1951 C C   . HIS   A 1 366 ? 128.953 119.795 146.978 1.00 75.78  ? 310 HIS   R C   1 
ATOM   1952 O O   . HIS   A 1 366 ? 128.731 119.342 145.849 1.00 75.78  ? 310 HIS   R O   1 
ATOM   1953 C CB  . HIS   A 1 366 ? 127.182 119.590 148.720 1.00 75.78  ? 310 HIS   R CB  1 
ATOM   1954 C CG  . HIS   A 1 366 ? 126.070 119.475 147.724 1.00 75.78  ? 310 HIS   R CG  1 
ATOM   1955 N ND1 . HIS   A 1 366 ? 124.857 120.109 147.886 1.00 75.78  ? 310 HIS   R ND1 1 
ATOM   1956 C CD2 . HIS   A 1 366 ? 125.986 118.801 146.552 1.00 75.78  ? 310 HIS   R CD2 1 
ATOM   1957 C CE1 . HIS   A 1 366 ? 124.076 119.833 146.857 1.00 75.78  ? 310 HIS   R CE1 1 
ATOM   1958 N NE2 . HIS   A 1 366 ? 124.737 119.041 146.033 1.00 75.78  ? 310 HIS   R NE2 1 
ATOM   1959 N N   . CYS   A 1 367 ? 129.546 120.971 147.167 1.00 78.74  ? 311 CYS   R N   1 
ATOM   1960 C CA  . CYS   A 1 367 ? 129.976 121.770 146.026 1.00 78.74  ? 311 CYS   R CA  1 
ATOM   1961 C C   . CYS   A 1 367 ? 131.038 121.029 145.224 1.00 78.74  ? 311 CYS   R C   1 
ATOM   1962 O O   . CYS   A 1 367 ? 131.104 121.144 143.995 1.00 78.74  ? 311 CYS   R O   1 
ATOM   1963 C CB  . CYS   A 1 367 ? 130.498 123.126 146.500 1.00 78.74  ? 311 CYS   R CB  1 
ATOM   1964 S SG  . CYS   A 1 367 ? 131.152 124.147 145.172 1.00 78.74  ? 311 CYS   R SG  1 
ATOM   1965 N N   . CYS   A 1 368 ? 131.889 120.265 145.912 1.00 80.69  ? 312 CYS   R N   1 
ATOM   1966 C CA  . CYS   A 1 368 ? 132.885 119.461 145.208 1.00 80.69  ? 312 CYS   R CA  1 
ATOM   1967 C C   . CYS   A 1 368 ? 132.255 118.238 144.553 1.00 80.69  ? 312 CYS   R C   1 
ATOM   1968 O O   . CYS   A 1 368 ? 132.745 117.765 143.522 1.00 80.69  ? 312 CYS   R O   1 
ATOM   1969 C CB  . CYS   A 1 368 ? 133.989 119.018 146.167 1.00 80.69  ? 312 CYS   R CB  1 
ATOM   1970 S SG  . CYS   A 1 368 ? 133.722 117.371 146.866 1.00 80.69  ? 312 CYS   R SG  1 
ATOM   1971 N N   . LEU   A 1 369 ? 131.189 117.698 145.146 1.00 75.30  ? 313 LEU   R N   1 
ATOM   1972 C CA  . LEU   A 1 369 ? 130.553 116.507 144.588 1.00 75.30  ? 313 LEU   R CA  1 
ATOM   1973 C C   . LEU   A 1 369 ? 129.725 116.838 143.352 1.00 75.30  ? 313 LEU   R C   1 
ATOM   1974 O O   . LEU   A 1 369 ? 129.546 115.985 142.474 1.00 75.30  ? 313 LEU   R O   1 
ATOM   1975 C CB  . LEU   A 1 369 ? 129.670 115.836 145.643 1.00 75.30  ? 313 LEU   R CB  1 
ATOM   1976 C CG  . LEU   A 1 369 ? 130.340 115.062 146.782 1.00 75.30  ? 313 LEU   R CG  1 
ATOM   1977 C CD1 . LEU   A 1 369 ? 129.310 114.204 147.500 1.00 75.30  ? 313 LEU   R CD1 1 
ATOM   1978 C CD2 . LEU   A 1 369 ? 131.485 114.198 146.279 1.00 75.30  ? 313 LEU   R CD2 1 
ATOM   1979 N N   . ASN   A 1 370 ? 129.203 118.062 143.272 1.00 70.27  ? 314 ASN   R N   1 
ATOM   1980 C CA  . ASN   A 1 370 ? 128.262 118.449 142.222 1.00 70.27  ? 314 ASN   R CA  1 
ATOM   1981 C C   . ASN   A 1 370 ? 128.668 117.933 140.845 1.00 70.27  ? 314 ASN   R C   1 
ATOM   1982 O O   . ASN   A 1 370 ? 127.833 117.357 140.138 1.00 70.27  ? 314 ASN   R O   1 
ATOM   1983 C CB  . ASN   A 1 370 ? 128.119 119.972 142.170 1.00 70.27  ? 314 ASN   R CB  1 
ATOM   1984 C CG  . ASN   A 1 370 ? 126.675 120.430 142.258 1.00 70.27  ? 314 ASN   R CG  1 
ATOM   1985 O OD1 . ASN   A 1 370 ? 125.748 119.623 142.217 1.00 70.27  ? 314 ASN   R OD1 1 
ATOM   1986 N ND2 . ASN   A 1 370 ? 126.479 121.737 142.379 1.00 70.27  ? 314 ASN   R ND2 1 
ATOM   1987 N N   . PRO   A 1 371 ? 129.920 118.119 140.418 1.00 71.69  ? 315 PRO   R N   1 
ATOM   1988 C CA  . PRO   A 1 371 ? 130.313 117.642 139.086 1.00 71.69  ? 315 PRO   R CA  1 
ATOM   1989 C C   . PRO   A 1 371 ? 130.029 116.165 138.872 1.00 71.69  ? 315 PRO   R C   1 
ATOM   1990 O O   . PRO   A 1 371 ? 129.592 115.763 137.790 1.00 71.69  ? 315 PRO   R O   1 
ATOM   1991 C CB  . PRO   A 1 371 ? 131.817 117.927 139.050 1.00 71.69  ? 315 PRO   R CB  1 
ATOM   1992 C CG  . PRO   A 1 371 ? 131.980 119.107 139.923 1.00 71.69  ? 315 PRO   R CG  1 
ATOM   1993 C CD  . PRO   A 1 371 ? 130.982 118.930 141.038 1.00 71.69  ? 315 PRO   R CD  1 
ATOM   1994 N N   . LEU   A 1 372 ? 130.276 115.345 139.896 1.00 67.96  ? 316 LEU   R N   1 
ATOM   1995 C CA  . LEU   A 1 372 ? 130.060 113.909 139.755 1.00 67.96  ? 316 LEU   R CA  1 
ATOM   1996 C C   . LEU   A 1 372 ? 128.582 113.565 139.644 1.00 67.96  ? 316 LEU   R C   1 
ATOM   1997 O O   . LEU   A 1 372 ? 128.201 112.734 138.814 1.00 67.96  ? 316 LEU   R O   1 
ATOM   1998 C CB  . LEU   A 1 372 ? 130.680 113.165 140.938 1.00 67.96  ? 316 LEU   R CB  1 
ATOM   1999 C CG  . LEU   A 1 372 ? 130.357 111.672 141.018 1.00 67.96  ? 316 LEU   R CG  1 
ATOM   2000 C CD1 . LEU   A 1 372 ? 131.610 110.879 141.338 1.00 67.96  ? 316 LEU   R CD1 1 
ATOM   2001 C CD2 . LEU   A 1 372 ? 129.277 111.406 142.055 1.00 67.96  ? 316 LEU   R CD2 1 
ATOM   2002 N N   . LEU   A 1 373 ? 127.736 114.188 140.464 1.00 63.09  ? 317 LEU   R N   1 
ATOM   2003 C CA  . LEU   A 1 373 ? 126.329 113.822 140.553 1.00 63.09  ? 317 LEU   R CA  1 
ATOM   2004 C C   . LEU   A 1 373 ? 125.477 114.403 139.435 1.00 63.09  ? 317 LEU   R C   1 
ATOM   2005 O O   . LEU   A 1 373 ? 124.342 113.953 139.252 1.00 63.09  ? 317 LEU   R O   1 
ATOM   2006 C CB  . LEU   A 1 373 ? 125.750 114.276 141.898 1.00 63.09  ? 317 LEU   R CB  1 
ATOM   2007 C CG  . LEU   A 1 373 ? 125.932 113.321 143.075 1.00 63.09  ? 317 LEU   R CG  1 
ATOM   2008 C CD1 . LEU   A 1 373 ? 125.474 113.981 144.366 1.00 63.09  ? 317 LEU   R CD1 1 
ATOM   2009 C CD2 . LEU   A 1 373 ? 125.176 112.026 142.836 1.00 63.09  ? 317 LEU   R CD2 1 
ATOM   2010 N N   . TYR   A 1 374 ? 125.986 115.383 138.691 1.00 61.08  ? 318 TYR   R N   1 
ATOM   2011 C CA  . TYR   A 1 374 ? 125.205 116.063 137.670 1.00 61.08  ? 318 TYR   R CA  1 
ATOM   2012 C C   . TYR   A 1 374 ? 125.778 115.946 136.269 1.00 61.08  ? 318 TYR   R C   1 
ATOM   2013 O O   . TYR   A 1 374 ? 125.009 116.015 135.305 1.00 61.08  ? 318 TYR   R O   1 
ATOM   2014 C CB  . TYR   A 1 374 ? 125.066 117.555 138.013 1.00 61.08  ? 318 TYR   R CB  1 
ATOM   2015 C CG  . TYR   A 1 374 ? 123.754 117.910 138.668 1.00 61.08  ? 318 TYR   R CG  1 
ATOM   2016 C CD1 . TYR   A 1 374 ? 122.605 118.072 137.911 1.00 61.08  ? 318 TYR   R CD1 1 
ATOM   2017 C CD2 . TYR   A 1 374 ? 123.663 118.083 140.042 1.00 61.08  ? 318 TYR   R CD2 1 
ATOM   2018 C CE1 . TYR   A 1 374 ? 121.402 118.395 138.501 1.00 61.08  ? 318 TYR   R CE1 1 
ATOM   2019 C CE2 . TYR   A 1 374 ? 122.464 118.407 140.641 1.00 61.08  ? 318 TYR   R CE2 1 
ATOM   2020 C CZ  . TYR   A 1 374 ? 121.337 118.562 139.866 1.00 61.08  ? 318 TYR   R CZ  1 
ATOM   2021 O OH  . TYR   A 1 374 ? 120.136 118.885 140.452 1.00 61.08  ? 318 TYR   R OH  1 
ATOM   2022 N N   . ALA   A 1 375 ? 127.091 115.766 136.123 1.00 68.69  ? 319 ALA   R N   1 
ATOM   2023 C CA  . ALA   A 1 375 ? 127.734 115.794 134.815 1.00 68.69  ? 319 ALA   R CA  1 
ATOM   2024 C C   . ALA   A 1 375 ? 128.305 114.440 134.418 1.00 68.69  ? 319 ALA   R C   1 
ATOM   2025 O O   . ALA   A 1 375 ? 127.950 113.917 133.358 1.00 68.69  ? 319 ALA   R O   1 
ATOM   2026 C CB  . ALA   A 1 375 ? 128.837 116.859 134.812 1.00 68.69  ? 319 ALA   R CB  1 
ATOM   2027 N N   . PHE   A 1 376 ? 129.171 113.847 135.240 1.00 70.50  ? 320 PHE   R N   1 
ATOM   2028 C CA  . PHE   A 1 376 ? 129.914 112.664 134.822 1.00 70.50  ? 320 PHE   R CA  1 
ATOM   2029 C C   . PHE   A 1 376 ? 129.049 111.418 134.694 1.00 70.50  ? 320 PHE   R C   1 
ATOM   2030 O O   . PHE   A 1 376 ? 129.513 110.430 134.114 1.00 70.50  ? 320 PHE   R O   1 
ATOM   2031 C CB  . PHE   A 1 376 ? 131.051 112.390 135.805 1.00 70.50  ? 320 PHE   R CB  1 
ATOM   2032 C CG  . PHE   A 1 376 ? 132.292 113.187 135.531 1.00 70.50  ? 320 PHE   R CG  1 
ATOM   2033 C CD1 . PHE   A 1 376 ? 132.245 114.569 135.470 1.00 70.50  ? 320 PHE   R CD1 1 
ATOM   2034 C CD2 . PHE   A 1 376 ? 133.509 112.556 135.341 1.00 70.50  ? 320 PHE   R CD2 1 
ATOM   2035 C CE1 . PHE   A 1 376 ? 133.387 115.304 135.219 1.00 70.50  ? 320 PHE   R CE1 1 
ATOM   2036 C CE2 . PHE   A 1 376 ? 134.654 113.287 135.090 1.00 70.50  ? 320 PHE   R CE2 1 
ATOM   2037 C CZ  . PHE   A 1 376 ? 134.592 114.663 135.030 1.00 70.50  ? 320 PHE   R CZ  1 
ATOM   2038 N N   . VAL   A 1 377 ? 127.814 111.428 135.211 1.00 65.17  ? 321 VAL   R N   1 
ATOM   2039 C CA  . VAL   A 1 377 ? 126.970 110.236 135.168 1.00 65.17  ? 321 VAL   R CA  1 
ATOM   2040 C C   . VAL   A 1 377 ? 126.210 110.100 133.859 1.00 65.17  ? 321 VAL   R C   1 
ATOM   2041 O O   . VAL   A 1 377 ? 125.692 109.014 133.567 1.00 65.17  ? 321 VAL   R O   1 
ATOM   2042 C CB  . VAL   A 1 377 ? 125.955 110.220 136.328 1.00 65.17  ? 321 VAL   R CB  1 
ATOM   2043 C CG1 . VAL   A 1 377 ? 126.627 110.616 137.622 1.00 65.17  ? 321 VAL   R CG1 1 
ATOM   2044 C CG2 . VAL   A 1 377 ? 124.785 111.145 136.024 1.00 65.17  ? 321 VAL   R CG2 1 
ATOM   2045 N N   . GLY   A 1 378 ? 126.121 111.161 133.063 1.00 69.75  ? 322 GLY   R N   1 
ATOM   2046 C CA  . GLY   A 1 378 ? 125.382 111.141 131.815 1.00 69.75  ? 322 GLY   R CA  1 
ATOM   2047 C C   . GLY   A 1 378 ? 126.234 110.558 130.699 1.00 69.75  ? 322 GLY   R C   1 
ATOM   2048 O O   . GLY   A 1 378 ? 127.418 110.875 130.580 1.00 69.75  ? 322 GLY   R O   1 
ATOM   2049 N N   . VAL   A 1 379 ? 125.609 109.703 129.888 1.00 75.69  ? 323 VAL   R N   1 
ATOM   2050 C CA  . VAL   A 1 379 ? 126.312 109.116 128.751 1.00 75.69  ? 323 VAL   R CA  1 
ATOM   2051 C C   . VAL   A 1 379 ? 126.748 110.207 127.785 1.00 75.69  ? 323 VAL   R C   1 
ATOM   2052 O O   . VAL   A 1 379 ? 127.849 110.160 127.222 1.00 75.69  ? 323 VAL   R O   1 
ATOM   2053 C CB  . VAL   A 1 379 ? 125.422 108.068 128.058 1.00 75.69  ? 323 VAL   R CB  1 
ATOM   2054 C CG1 . VAL   A 1 379 ? 126.075 107.583 126.773 1.00 75.69  ? 323 VAL   R CG1 1 
ATOM   2055 C CG2 . VAL   A 1 379 ? 125.142 106.905 128.998 1.00 75.69  ? 323 VAL   R CG2 1 
ATOM   2056 N N   . LYS   A 1 380 ? 125.886 111.202 127.572 1.00 76.52  ? 324 LYS   R N   1 
ATOM   2057 C CA  . LYS   A 1 380 ? 126.226 112.305 126.680 1.00 76.52  ? 324 LYS   R CA  1 
ATOM   2058 C C   . LYS   A 1 380 ? 127.525 112.975 127.108 1.00 76.52  ? 324 LYS   R C   1 
ATOM   2059 O O   . LYS   A 1 380 ? 128.445 113.149 126.300 1.00 76.52  ? 324 LYS   R O   1 
ATOM   2060 C CB  . LYS   A 1 380 ? 125.076 113.314 126.654 1.00 76.52  ? 324 LYS   R CB  1 
ATOM   2061 C CG  . LYS   A 1 380 ? 125.456 114.702 126.162 1.00 76.52  ? 324 LYS   R CG  1 
ATOM   2062 C CD  . LYS   A 1 380 ? 124.238 115.608 126.051 1.00 76.52  ? 324 LYS   R CD  1 
ATOM   2063 C CE  . LYS   A 1 380 ? 123.315 115.186 124.919 1.00 76.52  ? 324 LYS   R CE  1 
ATOM   2064 N NZ  . LYS   A 1 380 ? 122.381 116.279 124.529 1.00 76.52  ? 324 LYS   R NZ  1 
ATOM   2065 N N   . PHE   A 1 381 ? 127.622 113.353 128.384 1.00 73.13  ? 325 PHE   R N   1 
ATOM   2066 C CA  . PHE   A 1 381 ? 128.800 114.082 128.836 1.00 73.13  ? 325 PHE   R CA  1 
ATOM   2067 C C   . PHE   A 1 381 ? 130.034 113.193 128.830 1.00 73.13  ? 325 PHE   R C   1 
ATOM   2068 O O   . PHE   A 1 381 ? 131.138 113.667 128.553 1.00 73.13  ? 325 PHE   R O   1 
ATOM   2069 C CB  . PHE   A 1 381 ? 128.565 114.666 130.227 1.00 73.13  ? 325 PHE   R CB  1 
ATOM   2070 C CG  . PHE   A 1 381 ? 129.760 115.376 130.792 1.00 73.13  ? 325 PHE   R CG  1 
ATOM   2071 C CD1 . PHE   A 1 381 ? 130.779 114.672 131.411 1.00 73.13  ? 325 PHE   R CD1 1 
ATOM   2072 C CD2 . PHE   A 1 381 ? 129.871 116.750 130.694 1.00 73.13  ? 325 PHE   R CD2 1 
ATOM   2073 C CE1 . PHE   A 1 381 ? 131.879 115.324 131.926 1.00 73.13  ? 325 PHE   R CE1 1 
ATOM   2074 C CE2 . PHE   A 1 381 ? 130.969 117.408 131.207 1.00 73.13  ? 325 PHE   R CE2 1 
ATOM   2075 C CZ  . PHE   A 1 381 ? 131.975 116.693 131.824 1.00 73.13  ? 325 PHE   R CZ  1 
ATOM   2076 N N   . ARG   A 1 382 ? 129.881 111.908 129.152 1.00 76.07  ? 326 ARG   R N   1 
ATOM   2077 C CA  . ARG   A 1 382 ? 131.036 111.017 129.122 1.00 76.07  ? 326 ARG   R CA  1 
ATOM   2078 C C   . ARG   A 1 382 ? 131.561 110.850 127.702 1.00 76.07  ? 326 ARG   R C   1 
ATOM   2079 O O   . ARG   A 1 382 ? 132.779 110.850 127.476 1.00 76.07  ? 326 ARG   R O   1 
ATOM   2080 C CB  . ARG   A 1 382 ? 130.680 109.661 129.733 1.00 76.07  ? 326 ARG   R CB  1 
ATOM   2081 C CG  . ARG   A 1 382 ? 131.217 109.480 131.145 1.00 76.07  ? 326 ARG   R CG  1 
ATOM   2082 C CD  . ARG   A 1 382 ? 130.679 108.227 131.812 1.00 76.07  ? 326 ARG   R CD  1 
ATOM   2083 N NE  . ARG   A 1 382 ? 129.230 108.267 131.973 1.00 76.07  ? 326 ARG   R NE  1 
ATOM   2084 C CZ  . ARG   A 1 382 ? 128.374 107.432 131.397 1.00 76.07  ? 326 ARG   R CZ  1 
ATOM   2085 N NH1 . ARG   A 1 382 ? 128.780 106.456 130.600 1.00 76.07  ? 326 ARG   R NH1 1 
ATOM   2086 N NH2 . ARG   A 1 382 ? 127.073 107.578 131.630 1.00 76.07  ? 326 ARG   R NH2 1 
ATOM   2087 N N   . GLU   A 1 383 ? 130.659 110.712 126.729 1.00 81.78  ? 327 GLU   R N   1 
ATOM   2088 C CA  . GLU   A 1 383 ? 131.087 110.657 125.335 1.00 81.78  ? 327 GLU   R CA  1 
ATOM   2089 C C   . GLU   A 1 383 ? 131.771 111.956 124.931 1.00 81.78  ? 327 GLU   R C   1 
ATOM   2090 O O   . GLU   A 1 383 ? 132.798 111.941 124.242 1.00 81.78  ? 327 GLU   R O   1 
ATOM   2091 C CB  . GLU   A 1 383 ? 129.890 110.373 124.427 1.00 81.78  ? 327 GLU   R CB  1 
ATOM   2092 C CG  . GLU   A 1 383 ? 129.396 108.937 124.480 1.00 81.78  ? 327 GLU   R CG  1 
ATOM   2093 C CD  . GLU   A 1 383 ? 128.653 108.530 123.223 1.00 81.78  ? 327 GLU   R CD  1 
ATOM   2094 O OE1 . GLU   A 1 383 ? 127.663 109.206 122.871 1.00 81.78  ? 327 GLU   R OE1 1 
ATOM   2095 O OE2 . GLU   A 1 383 ? 129.059 107.536 122.585 1.00 81.78  ? 327 GLU   R OE2 1 
ATOM   2096 N N   . ARG   A 1 384 ? 131.214 113.094 125.353 1.00 80.20  ? 328 ARG   R N   1 
ATOM   2097 C CA  . ARG   A 1 384 ? 131.844 114.374 125.053 1.00 80.20  ? 328 ARG   R CA  1 
ATOM   2098 C C   . ARG   A 1 384 ? 133.252 114.433 125.624 1.00 80.20  ? 328 ARG   R C   1 
ATOM   2099 O O   . ARG   A 1 384 ? 134.190 114.866 124.947 1.00 80.20  ? 328 ARG   R O   1 
ATOM   2100 C CB  . ARG   A 1 384 ? 131.001 115.518 125.618 1.00 80.20  ? 328 ARG   R CB  1 
ATOM   2101 C CG  . ARG   A 1 384 ? 129.832 115.935 124.744 1.00 80.20  ? 328 ARG   R CG  1 
ATOM   2102 C CD  . ARG   A 1 384 ? 129.265 117.274 125.200 1.00 80.20  ? 328 ARG   R CD  1 
ATOM   2103 N NE  . ARG   A 1 384 ? 127.827 117.415 124.989 1.00 80.20  ? 328 ARG   R NE  1 
ATOM   2104 C CZ  . ARG   A 1 384 ? 127.197 117.239 123.832 1.00 80.20  ? 328 ARG   R CZ  1 
ATOM   2105 N NH1 . ARG   A 1 384 ? 127.844 116.889 122.732 1.00 80.20  ? 328 ARG   R NH1 1 
ATOM   2106 N NH2 . ARG   A 1 384 ? 125.881 117.424 123.777 1.00 80.20  ? 328 ARG   R NH2 1 
ATOM   2107 N N   . MET   A 1 385 ? 133.414 113.999 126.873 1.00 83.45  ? 329 MET   R N   1 
ATOM   2108 C CA  . MET   A 1 385 ? 134.715 114.043 127.531 1.00 83.45  ? 329 MET   R CA  1 
ATOM   2109 C C   . MET   A 1 385 ? 135.719 113.157 126.808 1.00 83.45  ? 329 MET   R C   1 
ATOM   2110 O O   . MET   A 1 385 ? 136.862 113.561 126.567 1.00 83.45  ? 329 MET   R O   1 
ATOM   2111 C CB  . MET   A 1 385 ? 134.570 113.611 128.991 1.00 83.45  ? 329 MET   R CB  1 
ATOM   2112 C CG  . MET   A 1 385 ? 135.876 113.534 129.763 1.00 83.45  ? 329 MET   R CG  1 
ATOM   2113 S SD  . MET   A 1 385 ? 135.607 113.146 131.503 1.00 83.45  ? 329 MET   R SD  1 
ATOM   2114 C CE  . MET   A 1 385 ? 136.897 114.116 132.278 1.00 83.45  ? 329 MET   R CE  1 
ATOM   2115 N N   . TRP   A 1 386 ? 135.311 111.937 126.455 1.00 88.93  ? 330 TRP   R N   1 
ATOM   2116 C CA  . TRP   A 1 386 ? 136.230 111.040 125.764 1.00 88.93  ? 330 TRP   R CA  1 
ATOM   2117 C C   . TRP   A 1 386 ? 136.611 111.592 124.396 1.00 88.93  ? 330 TRP   R C   1 
ATOM   2118 O O   . TRP   A 1 386 ? 137.782 111.538 123.999 1.00 88.93  ? 330 TRP   R O   1 
ATOM   2119 C CB  . TRP   A 1 386 ? 135.611 109.647 125.636 1.00 88.93  ? 330 TRP   R CB  1 
ATOM   2120 C CG  . TRP   A 1 386 ? 135.564 108.871 126.930 1.00 88.93  ? 330 TRP   R CG  1 
ATOM   2121 C CD1 . TRP   A 1 386 ? 134.513 108.141 127.403 1.00 88.93  ? 330 TRP   R CD1 1 
ATOM   2122 C CD2 . TRP   A 1 386 ? 136.614 108.735 127.902 1.00 88.93  ? 330 TRP   R CD2 1 
ATOM   2123 N NE1 . TRP   A 1 386 ? 134.837 107.568 128.609 1.00 88.93  ? 330 TRP   R NE1 1 
ATOM   2124 C CE2 . TRP   A 1 386 ? 136.121 107.916 128.936 1.00 88.93  ? 330 TRP   R CE2 1 
ATOM   2125 C CE3 . TRP   A 1 386 ? 137.921 109.226 127.998 1.00 88.93  ? 330 TRP   R CE3 1 
ATOM   2126 C CZ2 . TRP   A 1 386 ? 136.885 107.580 130.052 1.00 88.93  ? 330 TRP   R CZ2 1 
ATOM   2127 C CZ3 . TRP   A 1 386 ? 138.676 108.892 129.107 1.00 88.93  ? 330 TRP   R CZ3 1 
ATOM   2128 C CH2 . TRP   A 1 386 ? 138.157 108.076 130.118 1.00 88.93  ? 330 TRP   R CH2 1 
ATOM   2129 N N   . MET   A 1 387 ? 135.641 112.144 123.664 1.00 90.97  ? 331 MET   R N   1 
ATOM   2130 C CA  . MET   A 1 387 ? 135.943 112.725 122.361 1.00 90.97  ? 331 MET   R CA  1 
ATOM   2131 C C   . MET   A 1 387 ? 136.907 113.897 122.498 1.00 90.97  ? 331 MET   R C   1 
ATOM   2132 O O   . MET   A 1 387 ? 137.854 114.032 121.713 1.00 90.97  ? 331 MET   R O   1 
ATOM   2133 C CB  . MET   A 1 387 ? 134.652 113.171 121.675 1.00 90.97  ? 331 MET   R CB  1 
ATOM   2134 C CG  . MET   A 1 387 ? 134.035 112.122 120.764 1.00 90.97  ? 331 MET   R CG  1 
ATOM   2135 S SD  . MET   A 1 387 ? 132.946 112.840 119.518 1.00 90.97  ? 331 MET   R SD  1 
ATOM   2136 C CE  . MET   A 1 387 ? 131.712 113.620 120.556 1.00 90.97  ? 331 MET   R CE  1 
ATOM   2137 N N   . LEU   A 1 388 ? 136.682 114.757 123.493 1.00 86.05  ? 332 LEU   R N   1 
ATOM   2138 C CA  . LEU   A 1 388 ? 137.558 115.905 123.691 1.00 86.05  ? 332 LEU   R CA  1 
ATOM   2139 C C   . LEU   A 1 388 ? 138.966 115.472 124.078 1.00 86.05  ? 332 LEU   R C   1 
ATOM   2140 O O   . LEU   A 1 388 ? 139.946 116.054 123.599 1.00 86.05  ? 332 LEU   R O   1 
ATOM   2141 C CB  . LEU   A 1 388 ? 136.965 116.829 124.754 1.00 86.05  ? 332 LEU   R CB  1 
ATOM   2142 C CG  . LEU   A 1 388 ? 137.881 117.923 125.301 1.00 86.05  ? 332 LEU   R CG  1 
ATOM   2143 C CD1 . LEU   A 1 388 ? 138.366 118.824 124.178 1.00 86.05  ? 332 LEU   R CD1 1 
ATOM   2144 C CD2 . LEU   A 1 388 ? 137.150 118.727 126.358 1.00 86.05  ? 332 LEU   R CD2 1 
ATOM   2145 N N   . LEU   A 1 389 ? 139.091 114.461 124.942 1.00 90.37  ? 333 LEU   R N   1 
ATOM   2146 C CA  . LEU   A 1 389 ? 140.415 113.961 125.294 1.00 90.37  ? 333 LEU   R CA  1 
ATOM   2147 C C   . LEU   A 1 389 ? 141.112 113.355 124.083 1.00 90.37  ? 333 LEU   R C   1 
ATOM   2148 O O   . LEU   A 1 389 ? 142.329 113.504 123.921 1.00 90.37  ? 333 LEU   R O   1 
ATOM   2149 C CB  . LEU   A 1 389 ? 140.317 112.932 126.422 1.00 90.37  ? 333 LEU   R CB  1 
ATOM   2150 C CG  . LEU   A 1 389 ? 139.734 113.380 127.766 1.00 90.37  ? 333 LEU   R CG  1 
ATOM   2151 C CD1 . LEU   A 1 389 ? 140.330 112.550 128.894 1.00 90.37  ? 333 LEU   R CD1 1 
ATOM   2152 C CD2 . LEU   A 1 389 ? 139.955 114.866 128.019 1.00 90.37  ? 333 LEU   R CD2 1 
ATOM   2153 N N   . LEU   A 1 390 ? 140.360 112.664 123.222 1.00 94.22  ? 334 LEU   R N   1 
ATOM   2154 C CA  . LEU   A 1 390 ? 140.955 112.118 122.007 1.00 94.22  ? 334 LEU   R CA  1 
ATOM   2155 C C   . LEU   A 1 390 ? 141.521 113.226 121.129 1.00 94.22  ? 334 LEU   R C   1 
ATOM   2156 O O   . LEU   A 1 390 ? 142.616 113.086 120.570 1.00 94.22  ? 334 LEU   R O   1 
ATOM   2157 C CB  . LEU   A 1 390 ? 139.920 111.300 121.236 1.00 94.22  ? 334 LEU   R CB  1 
ATOM   2158 C CG  . LEU   A 1 390 ? 139.527 109.956 121.853 1.00 94.22  ? 334 LEU   R CG  1 
ATOM   2159 C CD1 . LEU   A 1 390 ? 138.273 109.410 121.188 1.00 94.22  ? 334 LEU   R CD1 1 
ATOM   2160 C CD2 . LEU   A 1 390 ? 140.670 108.959 121.742 1.00 94.22  ? 334 LEU   R CD2 1 
ATOM   2161 N N   . ARG   A 1 391 ? 140.794 114.330 120.994 1.00 95.36  ? 335 ARG   R N   1 
ATOM   2162 C CA  . ARG   A 1 391 ? 141.253 115.464 120.201 1.00 95.36  ? 335 ARG   R CA  1 
ATOM   2163 C C   . ARG   A 1 391 ? 142.481 116.108 120.836 1.00 95.36  ? 335 ARG   R C   1 
ATOM   2164 O O   . ARG   A 1 391 ? 143.581 115.557 120.782 1.00 95.36  ? 335 ARG   R O   1 
ATOM   2165 C CB  . ARG   A 1 391 ? 140.136 116.499 120.053 1.00 95.36  ? 335 ARG   R CB  1 
ATOM   2166 C CG  . ARG   A 1 391 ? 139.886 116.944 118.623 1.00 95.36  ? 335 ARG   R CG  1 
ATOM   2167 C CD  . ARG   A 1 391 ? 138.640 117.809 118.529 1.00 95.36  ? 335 ARG   R CD  1 
ATOM   2168 N NE  . ARG   A 1 391 ? 137.428 117.045 118.802 1.00 95.36  ? 335 ARG   R NE  1 
ATOM   2169 C CZ  . ARG   A 1 391 ? 136.246 117.582 119.076 1.00 95.36  ? 335 ARG   R CZ  1 
ATOM   2170 N NH1 . ARG   A 1 391 ? 136.078 118.893 119.137 1.00 95.36  ? 335 ARG   R NH1 1 
ATOM   2171 N NH2 . ARG   A 1 391 ? 135.207 116.782 119.298 1.00 95.36  ? 335 ARG   R NH2 1 
HETATM 2172 C C4  . A1LW2 B 2 .   ? 131.388 134.965 153.246 1.00 96.60  ? 401 A1LW2 R C4  1 
HETATM 2173 C C5  . A1LW2 B 2 .   ? 130.864 134.213 154.430 1.00 96.60  ? 401 A1LW2 R C5  1 
HETATM 2174 C C6  . A1LW2 B 2 .   ? 131.735 133.583 155.203 1.00 96.60  ? 401 A1LW2 R C6  1 
HETATM 2175 C C7  . A1LW2 B 2 .   ? 133.178 134.030 155.108 1.00 96.60  ? 401 A1LW2 R C7  1 
HETATM 2176 C C8  . A1LW2 B 2 .   ? 133.141 135.569 154.913 1.00 96.60  ? 401 A1LW2 R C8  1 
HETATM 2177 C C13 . A1LW2 B 2 .   ? 130.567 131.015 154.396 1.00 96.60  ? 401 A1LW2 R C13 1 
HETATM 2178 C C15 . A1LW2 B 2 .   ? 128.361 130.063 153.644 1.00 96.60  ? 401 A1LW2 R C15 1 
HETATM 2179 C C17 . A1LW2 B 2 .   ? 128.114 127.750 152.983 1.00 96.60  ? 401 A1LW2 R C17 1 
HETATM 2180 C C20 . A1LW2 B 2 .   ? 127.291 126.648 152.414 1.00 96.60  ? 401 A1LW2 R C20 1 
HETATM 2181 C C21 . A1LW2 B 2 .   ? 126.176 126.208 153.132 1.00 96.60  ? 401 A1LW2 R C21 1 
HETATM 2182 C C22 . A1LW2 B 2 .   ? 125.362 125.199 152.640 1.00 96.60  ? 401 A1LW2 R C22 1 
HETATM 2183 C C24 . A1LW2 B 2 .   ? 126.738 125.021 150.691 1.00 96.60  ? 401 A1LW2 R C24 1 
HETATM 2184 C C1  . A1LW2 B 2 .   ? 133.242 132.733 152.791 1.00 96.60  ? 401 A1LW2 R C1  1 
HETATM 2185 C C11 . A1LW2 B 2 .   ? 128.957 132.296 155.809 1.00 96.60  ? 401 A1LW2 R C11 1 
HETATM 2186 C C12 . A1LW2 B 2 .   ? 130.207 130.448 156.791 1.00 96.60  ? 401 A1LW2 R C12 1 
HETATM 2187 C C14 . A1LW2 B 2 .   ? 129.695 129.864 153.968 1.00 96.60  ? 401 A1LW2 R C14 1 
HETATM 2188 C C16 . A1LW2 B 2 .   ? 127.583 129.027 153.159 1.00 96.60  ? 401 A1LW2 R C16 1 
HETATM 2189 C C18 . A1LW2 B 2 .   ? 129.454 127.555 153.314 1.00 96.60  ? 401 A1LW2 R C18 1 
HETATM 2190 C C19 . A1LW2 B 2 .   ? 130.229 128.595 153.798 1.00 96.60  ? 401 A1LW2 R C19 1 
HETATM 2191 C C2  . A1LW2 B 2 .   ? 133.681 133.938 153.625 1.00 96.60  ? 401 A1LW2 R C2  1 
HETATM 2192 C C23 . A1LW2 B 2 .   ? 125.642 124.609 151.426 1.00 96.60  ? 401 A1LW2 R C23 1 
HETATM 2193 C C25 . A1LW2 B 2 .   ? 127.554 126.031 151.183 1.00 96.60  ? 401 A1LW2 R C25 1 
HETATM 2194 C C27 . A1LW2 B 2 .   ? 135.192 134.102 153.458 1.00 96.60  ? 401 A1LW2 R C27 1 
HETATM 2195 C C3  . A1LW2 B 2 .   ? 132.877 135.253 153.425 1.00 96.60  ? 401 A1LW2 R C3  1 
HETATM 2196 C C9  . A1LW2 B 2 .   ? 131.388 132.503 156.187 1.00 96.60  ? 401 A1LW2 R C9  1 
HETATM 2197 I I26 . A1LW2 B 2 .   ? 129.199 126.597 150.013 1.00 96.60  ? 401 A1LW2 R I26 1 
HETATM 2198 N N10 . A1LW2 B 2 .   ? 130.270 131.567 155.792 1.00 96.60  ? 401 A1LW2 R N10 1 
# 
