data_8XWT
# 
_entry.id   8XWT 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XWT         pdb_00008xwt 10.2210/pdb8xwt/pdb 
WWPDB D_1300042050 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XWT 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              huqi@westlake.edu.cn 
_pdbx_contact_author.name_first         Qi 
_pdbx_contact_author.name_last          Hu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7803-7821 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, L.J.' 1 0000-0002-5541-3051 
'Hu, Q.'      2 0000-0001-7803-7821 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of SARS-CoV-2 3CLpro-L50F mutant with its peptidyl substrate' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, L.J.' 1 0000-0002-5541-3051 
primary 'Hu, Q.'      2 0000-0001-7803-7821 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase nsp5'                               33827.496 1   3.4.22.69 'L50F, C145A' ? ? 
2 polymer syn CYS-SER-GLY-VAL-THR-PHE-GLN-SER-ALA-VAL-LYS-ARG-THR-ILE 1498.746  1   ?         ?             ? ? 
3 water   nat water                                                   18.015    233 ?         ?             ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSAGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSAGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
A ? 
2 'polypeptide(L)' no no CSGVTFQSAVKRTI CSGVTFQSAVKRTI B ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 ALA n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
2 1   CYS n 
2 2   SER n 
2 3   GLY n 
2 4   VAL n 
2 5   THR n 
2 6   PHE n 
2 7   GLN n 
2 8   SER n 
2 9   ALA n 
2 10  VAL n 
2 11  LYS n 
2 12  ARG n 
2 13  THR n 
2 14  ILE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       14 
_pdbx_entity_src_syn.organism_scientific    'Severe acute respiratory syndrome coronavirus 2' 
_pdbx_entity_src_syn.organism_common_name   '2019-nCoV, SARS-CoV-2' 
_pdbx_entity_src_syn.ncbi_taxonomy_id       2697049 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
B 2 1   CYS 1   0   ?   ?   ?   B . n 
B 2 2   SER 2   1   1   SER SER B . n 
B 2 3   GLY 3   2   2   GLY GLY B . n 
B 2 4   VAL 4   3   3   VAL VAL B . n 
B 2 5   THR 5   4   4   THR THR B . n 
B 2 6   PHE 6   5   5   PHE PHE B . n 
B 2 7   GLN 7   6   6   GLN GLN B . n 
B 2 8   SER 8   7   7   SER SER B . n 
B 2 9   ALA 9   8   8   ALA ALA B . n 
B 2 10  VAL 10  9   9   VAL VAL B . n 
B 2 11  LYS 11  10  10  LYS LYS B . n 
B 2 12  ARG 12  11  ?   ?   ?   B . n 
B 2 13  THR 13  12  ?   ?   ?   B . n 
B 2 14  ILE 14  13  ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   401 74  HOH HOH A . 
C 3 HOH 2   402 139 HOH HOH A . 
C 3 HOH 3   403 169 HOH HOH A . 
C 3 HOH 4   404 80  HOH HOH A . 
C 3 HOH 5   405 67  HOH HOH A . 
C 3 HOH 6   406 87  HOH HOH A . 
C 3 HOH 7   407 100 HOH HOH A . 
C 3 HOH 8   408 215 HOH HOH A . 
C 3 HOH 9   409 122 HOH HOH A . 
C 3 HOH 10  410 47  HOH HOH A . 
C 3 HOH 11  411 147 HOH HOH A . 
C 3 HOH 12  412 144 HOH HOH A . 
C 3 HOH 13  413 31  HOH HOH A . 
C 3 HOH 14  414 124 HOH HOH A . 
C 3 HOH 15  415 233 HOH HOH A . 
C 3 HOH 16  416 53  HOH HOH A . 
C 3 HOH 17  417 94  HOH HOH A . 
C 3 HOH 18  418 17  HOH HOH A . 
C 3 HOH 19  419 210 HOH HOH A . 
C 3 HOH 20  420 141 HOH HOH A . 
C 3 HOH 21  421 150 HOH HOH A . 
C 3 HOH 22  422 168 HOH HOH A . 
C 3 HOH 23  423 30  HOH HOH A . 
C 3 HOH 24  424 57  HOH HOH A . 
C 3 HOH 25  425 128 HOH HOH A . 
C 3 HOH 26  426 97  HOH HOH A . 
C 3 HOH 27  427 162 HOH HOH A . 
C 3 HOH 28  428 225 HOH HOH A . 
C 3 HOH 29  429 79  HOH HOH A . 
C 3 HOH 30  430 160 HOH HOH A . 
C 3 HOH 31  431 114 HOH HOH A . 
C 3 HOH 32  432 129 HOH HOH A . 
C 3 HOH 33  433 43  HOH HOH A . 
C 3 HOH 34  434 112 HOH HOH A . 
C 3 HOH 35  435 62  HOH HOH A . 
C 3 HOH 36  436 23  HOH HOH A . 
C 3 HOH 37  437 230 HOH HOH A . 
C 3 HOH 38  438 212 HOH HOH A . 
C 3 HOH 39  439 38  HOH HOH A . 
C 3 HOH 40  440 37  HOH HOH A . 
C 3 HOH 41  441 110 HOH HOH A . 
C 3 HOH 42  442 41  HOH HOH A . 
C 3 HOH 43  443 196 HOH HOH A . 
C 3 HOH 44  444 44  HOH HOH A . 
C 3 HOH 45  445 125 HOH HOH A . 
C 3 HOH 46  446 98  HOH HOH A . 
C 3 HOH 47  447 18  HOH HOH A . 
C 3 HOH 48  448 81  HOH HOH A . 
C 3 HOH 49  449 69  HOH HOH A . 
C 3 HOH 50  450 51  HOH HOH A . 
C 3 HOH 51  451 26  HOH HOH A . 
C 3 HOH 52  452 65  HOH HOH A . 
C 3 HOH 53  453 187 HOH HOH A . 
C 3 HOH 54  454 2   HOH HOH A . 
C 3 HOH 55  455 48  HOH HOH A . 
C 3 HOH 56  456 14  HOH HOH A . 
C 3 HOH 57  457 91  HOH HOH A . 
C 3 HOH 58  458 70  HOH HOH A . 
C 3 HOH 59  459 159 HOH HOH A . 
C 3 HOH 60  460 50  HOH HOH A . 
C 3 HOH 61  461 46  HOH HOH A . 
C 3 HOH 62  462 56  HOH HOH A . 
C 3 HOH 63  463 190 HOH HOH A . 
C 3 HOH 64  464 7   HOH HOH A . 
C 3 HOH 65  465 29  HOH HOH A . 
C 3 HOH 66  466 131 HOH HOH A . 
C 3 HOH 67  467 34  HOH HOH A . 
C 3 HOH 68  468 5   HOH HOH A . 
C 3 HOH 69  469 4   HOH HOH A . 
C 3 HOH 70  470 27  HOH HOH A . 
C 3 HOH 71  471 180 HOH HOH A . 
C 3 HOH 72  472 223 HOH HOH A . 
C 3 HOH 73  473 204 HOH HOH A . 
C 3 HOH 74  474 92  HOH HOH A . 
C 3 HOH 75  475 20  HOH HOH A . 
C 3 HOH 76  476 10  HOH HOH A . 
C 3 HOH 77  477 25  HOH HOH A . 
C 3 HOH 78  478 78  HOH HOH A . 
C 3 HOH 79  479 163 HOH HOH A . 
C 3 HOH 80  480 58  HOH HOH A . 
C 3 HOH 81  481 3   HOH HOH A . 
C 3 HOH 82  482 15  HOH HOH A . 
C 3 HOH 83  483 155 HOH HOH A . 
C 3 HOH 84  484 178 HOH HOH A . 
C 3 HOH 85  485 156 HOH HOH A . 
C 3 HOH 86  486 42  HOH HOH A . 
C 3 HOH 87  487 109 HOH HOH A . 
C 3 HOH 88  488 105 HOH HOH A . 
C 3 HOH 89  489 9   HOH HOH A . 
C 3 HOH 90  490 191 HOH HOH A . 
C 3 HOH 91  491 89  HOH HOH A . 
C 3 HOH 92  492 6   HOH HOH A . 
C 3 HOH 93  493 33  HOH HOH A . 
C 3 HOH 94  494 93  HOH HOH A . 
C 3 HOH 95  495 66  HOH HOH A . 
C 3 HOH 96  496 108 HOH HOH A . 
C 3 HOH 97  497 21  HOH HOH A . 
C 3 HOH 98  498 145 HOH HOH A . 
C 3 HOH 99  499 8   HOH HOH A . 
C 3 HOH 100 500 213 HOH HOH A . 
C 3 HOH 101 501 165 HOH HOH A . 
C 3 HOH 102 502 54  HOH HOH A . 
C 3 HOH 103 503 11  HOH HOH A . 
C 3 HOH 104 504 82  HOH HOH A . 
C 3 HOH 105 505 116 HOH HOH A . 
C 3 HOH 106 506 111 HOH HOH A . 
C 3 HOH 107 507 172 HOH HOH A . 
C 3 HOH 108 508 39  HOH HOH A . 
C 3 HOH 109 509 13  HOH HOH A . 
C 3 HOH 110 510 96  HOH HOH A . 
C 3 HOH 111 511 55  HOH HOH A . 
C 3 HOH 112 512 142 HOH HOH A . 
C 3 HOH 113 513 175 HOH HOH A . 
C 3 HOH 114 514 95  HOH HOH A . 
C 3 HOH 115 515 28  HOH HOH A . 
C 3 HOH 116 516 221 HOH HOH A . 
C 3 HOH 117 517 118 HOH HOH A . 
C 3 HOH 118 518 52  HOH HOH A . 
C 3 HOH 119 519 59  HOH HOH A . 
C 3 HOH 120 520 88  HOH HOH A . 
C 3 HOH 121 521 71  HOH HOH A . 
C 3 HOH 122 522 19  HOH HOH A . 
C 3 HOH 123 523 143 HOH HOH A . 
C 3 HOH 124 524 136 HOH HOH A . 
C 3 HOH 125 525 119 HOH HOH A . 
C 3 HOH 126 526 123 HOH HOH A . 
C 3 HOH 127 527 209 HOH HOH A . 
C 3 HOH 128 528 227 HOH HOH A . 
C 3 HOH 129 529 200 HOH HOH A . 
C 3 HOH 130 530 158 HOH HOH A . 
C 3 HOH 131 531 61  HOH HOH A . 
C 3 HOH 132 532 16  HOH HOH A . 
C 3 HOH 133 533 106 HOH HOH A . 
C 3 HOH 134 534 63  HOH HOH A . 
C 3 HOH 135 535 103 HOH HOH A . 
C 3 HOH 136 536 121 HOH HOH A . 
C 3 HOH 137 537 72  HOH HOH A . 
C 3 HOH 138 538 45  HOH HOH A . 
C 3 HOH 139 539 24  HOH HOH A . 
C 3 HOH 140 540 173 HOH HOH A . 
C 3 HOH 141 541 217 HOH HOH A . 
C 3 HOH 142 542 22  HOH HOH A . 
C 3 HOH 143 543 157 HOH HOH A . 
C 3 HOH 144 544 77  HOH HOH A . 
C 3 HOH 145 545 182 HOH HOH A . 
C 3 HOH 146 546 197 HOH HOH A . 
C 3 HOH 147 547 133 HOH HOH A . 
C 3 HOH 148 548 120 HOH HOH A . 
C 3 HOH 149 549 222 HOH HOH A . 
C 3 HOH 150 550 40  HOH HOH A . 
C 3 HOH 151 551 189 HOH HOH A . 
C 3 HOH 152 552 208 HOH HOH A . 
C 3 HOH 153 553 86  HOH HOH A . 
C 3 HOH 154 554 151 HOH HOH A . 
C 3 HOH 155 555 192 HOH HOH A . 
C 3 HOH 156 556 226 HOH HOH A . 
C 3 HOH 157 557 177 HOH HOH A . 
C 3 HOH 158 558 104 HOH HOH A . 
C 3 HOH 159 559 193 HOH HOH A . 
C 3 HOH 160 560 1   HOH HOH A . 
C 3 HOH 161 561 127 HOH HOH A . 
C 3 HOH 162 562 179 HOH HOH A . 
C 3 HOH 163 563 64  HOH HOH A . 
C 3 HOH 164 564 36  HOH HOH A . 
C 3 HOH 165 565 202 HOH HOH A . 
C 3 HOH 166 566 203 HOH HOH A . 
C 3 HOH 167 567 231 HOH HOH A . 
C 3 HOH 168 568 135 HOH HOH A . 
C 3 HOH 169 569 219 HOH HOH A . 
C 3 HOH 170 570 195 HOH HOH A . 
C 3 HOH 171 571 181 HOH HOH A . 
C 3 HOH 172 572 152 HOH HOH A . 
C 3 HOH 173 573 205 HOH HOH A . 
C 3 HOH 174 574 154 HOH HOH A . 
C 3 HOH 175 575 148 HOH HOH A . 
C 3 HOH 176 576 229 HOH HOH A . 
C 3 HOH 177 577 232 HOH HOH A . 
C 3 HOH 178 578 206 HOH HOH A . 
C 3 HOH 179 579 201 HOH HOH A . 
C 3 HOH 180 580 115 HOH HOH A . 
C 3 HOH 181 581 134 HOH HOH A . 
C 3 HOH 182 582 167 HOH HOH A . 
C 3 HOH 183 583 90  HOH HOH A . 
C 3 HOH 184 584 85  HOH HOH A . 
C 3 HOH 185 585 101 HOH HOH A . 
C 3 HOH 186 586 99  HOH HOH A . 
C 3 HOH 187 587 12  HOH HOH A . 
C 3 HOH 188 588 137 HOH HOH A . 
C 3 HOH 189 589 174 HOH HOH A . 
C 3 HOH 190 590 194 HOH HOH A . 
C 3 HOH 191 591 176 HOH HOH A . 
C 3 HOH 192 592 126 HOH HOH A . 
C 3 HOH 193 593 49  HOH HOH A . 
C 3 HOH 194 594 32  HOH HOH A . 
C 3 HOH 195 595 117 HOH HOH A . 
C 3 HOH 196 596 199 HOH HOH A . 
C 3 HOH 197 597 216 HOH HOH A . 
C 3 HOH 198 598 84  HOH HOH A . 
C 3 HOH 199 599 188 HOH HOH A . 
C 3 HOH 200 600 153 HOH HOH A . 
C 3 HOH 201 601 228 HOH HOH A . 
C 3 HOH 202 602 75  HOH HOH A . 
C 3 HOH 203 603 198 HOH HOH A . 
C 3 HOH 204 604 35  HOH HOH A . 
C 3 HOH 205 605 164 HOH HOH A . 
C 3 HOH 206 606 140 HOH HOH A . 
C 3 HOH 207 607 102 HOH HOH A . 
C 3 HOH 208 608 171 HOH HOH A . 
C 3 HOH 209 609 184 HOH HOH A . 
C 3 HOH 210 610 161 HOH HOH A . 
C 3 HOH 211 611 224 HOH HOH A . 
C 3 HOH 212 612 113 HOH HOH A . 
C 3 HOH 213 613 220 HOH HOH A . 
C 3 HOH 214 614 185 HOH HOH A . 
C 3 HOH 215 615 186 HOH HOH A . 
C 3 HOH 216 616 132 HOH HOH A . 
C 3 HOH 217 617 214 HOH HOH A . 
C 3 HOH 218 618 146 HOH HOH A . 
C 3 HOH 219 619 73  HOH HOH A . 
C 3 HOH 220 620 138 HOH HOH A . 
C 3 HOH 221 621 68  HOH HOH A . 
C 3 HOH 222 622 149 HOH HOH A . 
C 3 HOH 223 623 107 HOH HOH A . 
C 3 HOH 224 624 207 HOH HOH A . 
C 3 HOH 225 625 83  HOH HOH A . 
D 3 HOH 1   101 60  HOH HOH B . 
D 3 HOH 2   102 166 HOH HOH B . 
D 3 HOH 3   103 76  HOH HOH B . 
D 3 HOH 4   104 130 HOH HOH B . 
D 3 HOH 5   105 170 HOH HOH B . 
D 3 HOH 6   106 211 HOH HOH B . 
D 3 HOH 7   107 183 HOH HOH B . 
D 3 HOH 8   108 218 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 1.171.40.73a 1 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.19.1_4122  2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 1.171.40.73a 3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 1.171.40.73a 4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.19.1_4122  5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   96.500 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XWT 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.570 
_cell.length_a_esd                 ? 
_cell.length_b                     81.222 
_cell.length_b_esd                 ? 
_cell.length_c                     87.056 
_cell.length_c_esd                 ? 
_cell.volume                       383372.560 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XWT 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XWT 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.71 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.05 M HEPES, pH = 7.0, 1% w/v Tryptone, 1 mM NaN3, 20% w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-6000HE' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    M 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.541 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-X' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.541 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          17.76 
_reflns.entry_id                                       8XWT 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.7 
_reflns.d_resolution_low                               29.84 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     41481 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.84 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          32.01 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.0611 
_reflns.pdbx_Rpim_I_all                                0.01843 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.05814 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.7 
_reflns_shell.d_res_low                                     1.761 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.58 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4126 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.3524 
_reflns_shell.pdbx_Rpim_I_all                               0.1461 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.954 
_reflns_shell.pdbx_CC_star                                  0.988 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.88 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.32 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               26.07 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XWT 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.70 
_refine.ls_d_res_low                             29.84 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     41024 
_refine.ls_number_reflns_R_free                  1977 
_refine.ls_number_reflns_R_work                  39047 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.86 
_refine.ls_percent_reflns_R_free                 4.82 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2167 
_refine.ls_R_factor_R_free                       0.2500 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2150 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.7712 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2263 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        29.84 
_refine_hist.number_atoms_solvent             233 
_refine_hist.number_atoms_total               2664 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2431 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0122 ? 2485 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2390 ? 3375 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0699 ? 381  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0100 ? 438  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.7552 ? 335  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.70 1.74  . . 141 2791 99.83  . . . . 0.2370 . . . . . . . . . . . 0.3080 
'X-RAY DIFFRACTION' 1.74 1.79  . . 141 2783 100.00 . . . . 0.2306 . . . . . . . . . . . 0.2488 
'X-RAY DIFFRACTION' 1.79 1.84  . . 144 2834 100.00 . . . . 0.2395 . . . . . . . . . . . 0.2913 
'X-RAY DIFFRACTION' 1.84 1.90  . . 136 2630 93.79  . . . . 0.4484 . . . . . . . . . . . 0.5796 
'X-RAY DIFFRACTION' 1.90 1.97  . . 138 2752 97.83  . . . . 0.3793 . . . . . . . . . . . 0.4220 
'X-RAY DIFFRACTION' 1.97 2.05  . . 144 2823 99.80  . . . . 0.2461 . . . . . . . . . . . 0.2874 
'X-RAY DIFFRACTION' 2.05 2.14  . . 141 2779 100.00 . . . . 0.2278 . . . . . . . . . . . 0.2682 
'X-RAY DIFFRACTION' 2.14 2.25  . . 137 2767 96.90  . . . . 0.2851 . . . . . . . . . . . 0.3073 
'X-RAY DIFFRACTION' 2.25 2.40  . . 136 2716 96.78  . . . . 0.2461 . . . . . . . . . . . 0.2964 
'X-RAY DIFFRACTION' 2.40 2.58  . . 143 2808 100.00 . . . . 0.2138 . . . . . . . . . . . 0.2559 
'X-RAY DIFFRACTION' 2.58 2.84  . . 143 2832 100.00 . . . . 0.2113 . . . . . . . . . . . 0.2072 
'X-RAY DIFFRACTION' 2.84 3.25  . . 144 2837 100.00 . . . . 0.2013 . . . . . . . . . . . 0.2330 
'X-RAY DIFFRACTION' 3.25 4.09  . . 143 2804 99.23  . . . . 0.1679 . . . . . . . . . . . 0.2217 
'X-RAY DIFFRACTION' 4.09 29.84 . . 146 2891 99.93  . . . . 0.1427 . . . . . . . . . . . 0.1515 
# 
_struct.entry_id                     8XWT 
_struct.title                        'Crystal structure of SARS-CoV-2 3CLpro-L50F mutant with its peptidyl substrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XWT 
_struct_keywords.text            'SARS-CoV-2 3CLpro, mutant, substrate, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP R1AB_SARS2 P0DTD1 ? 1 
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
3264 
2 PDB 8XWT       8XWT   ? 2 ? 1    
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XWT A 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1 306 
2 2 8XWT B 1 ? 14  ? 8XWT   0    ? 13   ? 0 13  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8XWT PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 8XWT ALA A 145 ? UNP P0DTD1 CYS 3408 'engineered mutation' 145 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6030  ? 
1 MORE         -26   ? 
1 'SSA (A^2)'  25260 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 45  ? MET A 49  ? THR A 45  MET A 49  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA2 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA2 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA2 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA2 5 ALA B 9   ? VAL B 10  ? ALA B 8   VAL B 9   
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
AA4 1 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA4 2 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA4 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA4 4 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA4 5 THR B 5   ? PHE B 6   ? THR B 4   PHE B 5   
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA2 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA2 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA2 4 5 N THR A 26  ? N THR A 26  O ALA B 9   ? O ALA B 8   
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
AA4 1 2 O TYR A 126 ? O TYR A 126 N VAL A 114 ? N VAL A 114 
AA4 2 3 N SER A 113 ? N SER A 113 O PHE A 150 ? O PHE A 150 
AA4 3 4 N ASN A 151 ? N ASN A 151 O SER A 158 ? O SER A 158 
AA4 4 5 N GLU A 166 ? N GLU A 166 O THR B 5   ? O THR B 4   
# 
_pdbx_entry_details.entry_id                   8XWT 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CB 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_1             128 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            SG 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            CYS 
_pdbx_validate_rmsd_bond.auth_seq_id_2             128 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.671 
_pdbx_validate_rmsd_bond.bond_target_value         1.812 
_pdbx_validate_rmsd_bond.bond_deviation            -0.141 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.016 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 53.85   -133.12 
2 1 ASN A 72  ? ? -109.40 50.63   
3 1 ASN A 84  ? ? 56.09   -124.37 
4 1 TYR A 154 ? ? 47.55   -110.95 
5 1 GLN B 6   ? ? -99.13  40.58   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 436 ? C HOH . 
2 1 A HOH 560 ? C HOH . 
3 1 A HOH 565 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       625 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.94 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLN 306 ? A GLN 306 
2 1 Y 1 B CYS 0   ? B CYS 1   
3 1 Y 1 B ARG 11  ? B ARG 12  
4 1 Y 1 B THR 12  ? B THR 13  
5 1 Y 1 B ILE 13  ? B ILE 14  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7EN8 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8XWT 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018325 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002088 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012312 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011561 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? -8.25971 -22.89069 14.84099  1.000 14.27216  ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? -7.78384 -24.17595 14.26578  1.000 15.96997  ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? -7.46665 -24.03185 12.77737  1.000 18.19591  ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? -7.84735 -23.02938 12.17457  1.000 15.08440  ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? -8.84415 -25.26466 14.45430  1.000 22.63766  ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? -9.17334 -25.34348 15.82583  1.000 29.54877  ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? -6.87849 -25.09048 12.19530  1.000 18.06487  ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? -6.44939 -25.20301 10.81769  1.000 15.12807  ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? -4.96219 -24.89610 10.68399  1.000 15.60621  ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? -4.33180 -24.31490 11.56691  1.000 17.35873  ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? -4.37733 -25.30563 9.56715   1.000 17.89349  ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? -2.95358 -25.03494 9.35907   1.000 16.19563  ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? -2.72441 -24.94658 7.86459   1.000 11.68734  ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? -2.94438 -25.92646 7.13316   1.000 21.63156  ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? -2.07090 -26.11539 9.99866   1.000 13.02771  ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? -0.67489 -25.63314 10.29592  1.000 16.45771  ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? -0.44683 -24.69683 11.27362  1.000 21.17765  ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? 0.39910  -26.08217 9.52043   1.000 16.51546  ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? 0.86466  -24.20762 11.51328  1.000 27.33779  ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? 1.71163  -25.61104 9.75624   1.000 12.98366  ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? 1.93436  -24.67477 10.74432  1.000 18.04554  ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? -2.34571 -23.76808 7.39363   1.000 13.71172  ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? -2.21685 -23.51959 5.97443   1.000 13.40356  ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? -0.78505 -23.11655 5.63321   1.000 14.60819  ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? -0.06613 -22.55861 6.47475   1.000 15.60268  ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? -3.18007 -22.40051 5.55955   1.000 13.63107  ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? -4.62660 -22.85556 5.33478   1.000 17.24707  ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? -4.74427 -23.66416 4.04920   1.000 21.16613  ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? -6.14578 -23.90616 3.71353   1.000 18.86527  ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? -6.57114 -24.44439 2.57044   1.000 20.06662  ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? -5.72886 -24.76587 1.59225   1.000 19.16061  ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? -7.86610 -24.73486 2.43369   1.000 16.48443  ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? -0.40359 -23.30306 4.36948   1.000 13.61989  ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? 0.84344  -22.71279 3.88962   1.000 12.37920  ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? 0.63291  -21.21479 3.82284   1.000 15.79638  ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? -0.10162 -20.73380 2.95257   1.000 21.41492  ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? 1.21616  -23.26138 2.50679   1.000 20.95593  ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? 2.19583  -24.39092 2.47579   1.000 37.38316  ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? 3.53890  -23.96165 3.02419   1.000 26.88532  ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? 4.45202  -25.17825 3.06677   1.000 30.48497  ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? 4.26723  -26.03875 1.87856   1.000 30.75352  ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? 1.20040  -20.46973 4.76750   1.000 13.51715  ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? 0.79689  -19.07904 4.95307   1.000 11.62226  ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? 1.95842  -18.15310 4.63062   1.000 16.19987  ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? 3.05269  -18.28172 5.21924   1.000 15.26102  ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? 0.32163  -18.87712 6.39941   1.000 15.54237  ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? 0.00564  -17.47276 6.77980   1.000 17.55232  ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? -0.96236 -17.44334 8.31790   1.000 33.26088  ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? -2.19390 -18.68155 8.02974   1.000 29.12340  ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? 1.71705  -17.21330 3.71574   1.000 14.23405  ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? 2.70467  -16.21451 3.31827   1.000 11.26799  ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? 2.49739  -14.93108 4.12030   1.000 13.34198  ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? 1.42028  -14.68264 4.69417   1.000 16.73170  ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? 2.60328  -15.93718 1.83083   1.000 13.81507  ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? 3.56237  -14.12672 4.22323   1.000 12.57998  ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? 3.38110  -12.79314 4.78913   1.000 15.80715  ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? 2.55210  -11.90096 3.86200   1.000 10.08463  ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? 2.58931  -12.04951 2.64159   1.000 18.10777  ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? 4.73571  -12.12806 5.07072   1.000 15.12510  ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? 5.48171  -12.78404 6.16118   1.000 18.07934  ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? 5.22900  -12.46875 7.47128   1.000 16.29975  ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? 6.48221  -13.72444 5.87599   1.000 17.35493  ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? 5.93168  -13.09767 8.47884   1.000 21.95920  ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? 7.17008  -14.35136 6.91010   1.000 13.53581  ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? 6.87967  -14.03349 8.19664   1.000 17.70817  ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? 1.81239  -10.94386 4.43818   1.000 13.68783  ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? 1.13270  -9.90935  3.64432   1.000 19.03890  ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? 2.13917  -9.20663  2.75064   1.000 17.10917  ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? 3.21357  -8.81273  3.20879   1.000 19.37282  ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? 0.57753  -8.96283  4.70964   1.000 16.90145  ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? 0.51897  -9.79224  5.98726   1.000 19.15898  ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? 1.69558  -10.73989 5.88527   1.000 17.01891  ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? 1.82657  -9.12921  1.45918   1.000 17.48574  ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? 2.78577  -8.70201  0.44359   1.000 13.97199  ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? 2.78046  -7.20140  0.16351   1.000 20.20625  ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? 3.58374  -6.75860  -0.66940  1.000 18.65497  ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? 2.53364  -9.43315  -0.87269  1.000 18.57403  ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? 1.18475  -9.21562  -1.32131  1.000 18.15573  ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? 1.89169  -6.42550  0.81071   1.000 16.07622  ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? 1.71236  -5.01846  0.43683   1.000 14.72308  ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? 2.98571  -4.18952  0.50364   1.000 16.51591  ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? 3.28886  -3.42267  -0.42035  1.000 19.72609  ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? 3.75437  -4.35501  1.57771   1.000 16.04088  ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? 4.99134  -3.58688  1.72268   1.000 17.26833  ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? 5.94897  -3.85545  0.56905   1.000 19.57512  ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? 6.72945  -2.96678  0.17622   1.000 20.04593  ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? 5.64692  -3.91235  3.06654   1.000 14.22756  ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? 5.24791  -2.96817  4.20864   1.000 24.86327  ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? 5.36349  -3.60850  5.58085   1.000 26.97038  ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? 4.62982  -2.78832  6.62932   1.000 28.74201  ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? 3.15330  -2.95376  6.50989   1.000 32.61986  ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? 5.90298  -5.05065  -0.00499  1.000 14.93485  ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? 6.81117  -5.37118  -1.11071  1.000 20.14638  ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? 6.23127  -4.94213  -2.45796  1.000 18.86076  ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? 6.97627  -4.55444  -3.35942  1.000 18.28264  ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? 7.13574  -6.88508  -1.08286  1.000 16.46196  ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? 8.03802  -7.31440  -2.23127  1.000 13.81759  ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? 7.73063  -7.22034  0.21680   1.000 15.91033  ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? 4.89657  -5.05253  -2.62834  1.000 14.63894  ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? 4.26393  -4.64628  -3.87780  1.000 15.93835  ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? 4.65205  -3.22474  -4.24911  1.000 14.66677  ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? 4.90095  -2.92158  -5.42442  1.000 20.43859  ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? 2.74220  -4.75722  -3.74317  1.000 17.08417  ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? 2.26213  -6.19060  -3.54527  1.000 17.75855  ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? 0.79307  -6.27565  -3.14407  1.000 21.63517  ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -0.01999 -5.61606  -3.78796  1.000 21.49935  ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? 0.47276  -6.92329  -2.13791  1.000 19.25647  ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? 4.68067  -2.34857  -3.26582  1.000 19.16551  ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? 5.02719  -0.95853  -3.51777  1.000 22.21831  ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? 6.46271  -0.72843  -3.92484  1.000 23.62930  ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? 6.83538  0.42095   -4.15670  1.000 19.18412  ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? 7.27412  -1.77980  -4.02353  1.000 19.73399  ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? 8.67232  -1.63822  -4.38309  1.000 19.90641  ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? 8.96477  -2.21744  -5.75426  1.000 20.38852  ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? 10.08847 -2.11729  -6.23508  1.000 17.39526  ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? 9.57338  -2.30429  -3.32545  1.000 13.66067  ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? 9.42753  -1.71327  -1.68326  1.000 21.54856  ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? 7.97788  -2.80349  -6.41999  1.000 16.43872  ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? 8.27820  -3.61173  -7.58197  1.000 16.64122  ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? 8.25144  -2.68655  -8.79771  1.000 18.66114  ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? 7.31189  -1.89458  -8.93560  1.000 20.40951  ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? 7.20815  -4.69580  -7.68660  1.000 21.25085  ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? 7.38293  -5.90779  -6.78086  1.000 18.35618  ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? 9.07756  -6.36828  -6.27062  1.000 18.54578  ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? 9.68479  -6.82746  -7.87085  1.000 15.21879  ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? 9.25078  -2.79902  -9.68390  1.000 21.66132  ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? 9.31648  -1.99228  -10.90349 1.000 14.68503  ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? 9.73944  -2.86878  -12.06917 1.000 22.13898  ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? 10.12662 -4.02672  -11.91101 1.000 17.21568  ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? 10.27305 -0.78321  -10.76462 1.000 19.68785  ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? 9.80903  0.12294   -9.65158  1.000 17.76977  ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? 11.72998 -1.25178  -10.56689 1.000 16.77305  ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? 9.68351  -2.28921  -13.25864 1.000 20.49460  ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? 10.07099 -2.97055  -14.46984 1.000 14.85487  ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? 11.41371 -2.41008  -14.89269 1.000 21.12525  ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? 11.62127 -1.19584  -14.84678 1.000 31.36749  ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? 9.04221  -2.75175  -15.57324 1.000 20.60595  ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? 9.38798  -3.35931  -16.90197 1.000 24.45682  ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? 8.13219  -3.53797  -17.77932 1.000 33.40738  ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? 7.16838  -2.78192  -17.65165 1.000 41.91692  ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? 8.14355  -4.53532  -18.65131 1.000 36.73936  ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? 12.32519 -3.28209  -15.28583 1.000 25.26910  ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? 13.62902 -2.86425  -15.77105 1.000 27.74621  ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? 13.84745 -3.47628  -17.14752 1.000 28.12012  ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? 13.71345 -4.69335  -17.33588 1.000 21.05255  ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? 14.75527 -3.25509  -14.78473 1.000 20.02243  ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? 16.12624 -2.80693  -15.32475 1.000 21.12017  ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? 14.49343 -2.64345  -13.42915 1.000 19.58877  ? 20  VAL A CG2 1 
ATOM   149  N N   . THR A 1 21  ? 14.20256 -2.63420  -18.11775 1.000 27.97966  ? 21  THR A N   1 
ATOM   150  C CA  . THR A 1 21  ? 14.41454 -3.09431  -19.47822 1.000 24.70950  ? 21  THR A CA  1 
ATOM   151  C C   . THR A 1 21  ? 15.74956 -2.57319  -19.98703 1.000 21.79336  ? 21  THR A C   1 
ATOM   152  O O   . THR A 1 21  ? 16.13361 -1.43911  -19.70333 1.000 33.20483  ? 21  THR A O   1 
ATOM   153  C CB  . THR A 1 21  ? 13.27408 -2.62530  -20.39499 1.000 30.35207  ? 21  THR A CB  1 
ATOM   154  O OG1 . THR A 1 21  ? 12.04201 -3.15670  -19.90952 1.000 27.31036  ? 21  THR A OG1 1 
ATOM   155  C CG2 . THR A 1 21  ? 13.49730 -3.15175  -21.81355 1.000 32.88391  ? 21  THR A CG2 1 
ATOM   156  N N   . CYS A 1 22  ? 16.46360 -3.42000  -20.70697 1.000 30.45396  ? 22  CYS A N   1 
ATOM   157  C CA  . CYS A 1 22  ? 17.74096 -3.05907  -21.29635 1.000 27.85249  ? 22  CYS A CA  1 
ATOM   158  C C   . CYS A 1 22  ? 17.76393 -3.74320  -22.65534 1.000 32.91307  ? 22  CYS A C   1 
ATOM   159  O O   . CYS A 1 22  ? 17.76649 -4.97694  -22.74044 1.000 28.24332  ? 22  CYS A O   1 
ATOM   160  C CB  . CYS A 1 22  ? 18.90807 -3.48669  -20.39784 1.000 24.93535  ? 22  CYS A CB  1 
ATOM   161  S SG  . CYS A 1 22  ? 20.54972 -2.99119  -21.00474 1.000 34.99473  ? 22  CYS A SG  1 
ATOM   162  N N   . GLY A 1 23  ? 17.70008 -2.94868  -23.71553 1.000 32.68260  ? 23  GLY A N   1 
ATOM   163  C CA  . GLY A 1 23  ? 17.64229 -3.53754  -25.04197 1.000 39.87988  ? 23  GLY A CA  1 
ATOM   164  C C   . GLY A 1 23  ? 16.30398 -4.20952  -25.23604 1.000 34.28046  ? 23  GLY A C   1 
ATOM   165  O O   . GLY A 1 23  ? 15.24011 -3.62101  -24.98025 1.000 35.47683  ? 23  GLY A O   1 
ATOM   166  N N   . THR A 1 24  ? 16.35022 -5.47628  -25.65137 1.000 33.94284  ? 24  THR A N   1 
ATOM   167  C CA  . THR A 1 24  ? 15.14472 -6.26982  -25.82877 1.000 43.52944  ? 24  THR A CA  1 
ATOM   168  C C   . THR A 1 24  ? 14.89869 -7.22547  -24.64693 1.000 40.68953  ? 24  THR A C   1 
ATOM   169  O O   . THR A 1 24  ? 14.10188 -8.16119  -24.76172 1.000 40.20768  ? 24  THR A O   1 
ATOM   170  C CB  . THR A 1 24  ? 15.22324 -7.02575  -27.16491 1.000 30.70812  ? 24  THR A CB  1 
ATOM   171  O OG1 . THR A 1 24  ? 14.09145 -7.88834  -27.30526 1.000 58.61632  ? 24  THR A OG1 1 
ATOM   172  C CG2 . THR A 1 24  ? 16.48024 -7.85571  -27.26108 1.000 44.14431  ? 24  THR A CG2 1 
ATOM   173  N N   . THR A 1 25  ? 15.55053 -6.99433  -23.50889 1.000 35.38521  ? 25  THR A N   1 
ATOM   174  C CA  . THR A 1 25  ? 15.44751 -7.86976  -22.33824 1.000 29.70871  ? 25  THR A CA  1 
ATOM   175  C C   . THR A 1 25  ? 14.77565 -7.12359  -21.19798 1.000 25.41377  ? 25  THR A C   1 
ATOM   176  O O   . THR A 1 25  ? 15.21957 -6.03647  -20.81219 1.000 28.66249  ? 25  THR A O   1 
ATOM   177  C CB  . THR A 1 25  ? 16.83227 -8.37338  -21.91816 1.000 25.43119  ? 25  THR A CB  1 
ATOM   178  O OG1 . THR A 1 25  ? 17.39556 -9.14352  -22.98269 1.000 34.57848  ? 25  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 25  ? 16.76016 -9.25007  -20.63912 1.000 23.78472  ? 25  THR A CG2 1 
ATOM   180  N N   . THR A 1 26  ? 13.71636 -7.70386  -20.64248 1.000 24.94526  ? 26  THR A N   1 
ATOM   181  C CA  . THR A 1 26  ? 13.03058 -7.03665  -19.55840 1.000 25.60482  ? 26  THR A CA  1 
ATOM   182  C C   . THR A 1 26  ? 12.82980 -8.02246  -18.41207 1.000 17.71602  ? 26  THR A C   1 
ATOM   183  O O   . THR A 1 26  ? 12.79663 -9.23682  -18.61838 1.000 21.54305  ? 26  THR A O   1 
ATOM   184  C CB  . THR A 1 26  ? 11.70296 -6.46382  -20.01220 1.000 26.17138  ? 26  THR A CB  1 
ATOM   185  O OG1 . THR A 1 26  ? 11.12336 -5.73889  -18.93184 1.000 24.31891  ? 26  THR A OG1 1 
ATOM   186  C CG2 . THR A 1 26  ? 10.76513 -7.57594  -20.40239 1.000 29.09384  ? 26  THR A CG2 1 
ATOM   187  N N   . LEU A 1 27  ? 12.77810 -7.48085  -17.20589 1.000 19.18478  ? 27  LEU A N   1 
ATOM   188  C CA  . LEU A 1 27  ? 12.53591 -8.26727  -15.99225 1.000 26.54422  ? 27  LEU A CA  1 
ATOM   189  C C   . LEU A 1 27  ? 12.12606 -7.28821  -14.90078 1.000 19.65964  ? 27  LEU A C   1 
ATOM   190  O O   . LEU A 1 27  ? 11.88028 -6.10877  -15.16888 1.000 21.26918  ? 27  LEU A O   1 
ATOM   191  C CB  . LEU A 1 27  ? 13.75775 -9.11473  -15.62124 1.000 17.11683  ? 27  LEU A CB  1 
ATOM   192  C CG  . LEU A 1 27  ? 15.15784 -8.49928  -15.68871 1.000 14.33235  ? 27  LEU A CG  1 
ATOM   193  C CD1 . LEU A 1 27  ? 15.34026 -7.31747  -14.74429 1.000 20.19015  ? 27  LEU A CD1 1 
ATOM   194  C CD2 . LEU A 1 27  ? 16.17488 -9.57892  -15.36123 1.000 17.59572  ? 27  LEU A CD2 1 
ATOM   195  N N   . ASN A 1 28  ? 12.04531 -7.76075  -13.66165 1.000 14.86170  ? 28  ASN A N   1 
ATOM   196  C CA  . ASN A 1 28  ? 11.55569 -6.94514  -12.55544 1.000 13.29289  ? 28  ASN A CA  1 
ATOM   197  C C   . ASN A 1 28  ? 12.72743 -6.40518  -11.74136 1.000 11.97121  ? 28  ASN A C   1 
ATOM   198  O O   . ASN A 1 28  ? 13.77655 -7.03751  -11.66023 1.000 15.29695  ? 28  ASN A O   1 
ATOM   199  C CB  . ASN A 1 28  ? 10.65999 -7.76392  -11.62032 1.000 17.37534  ? 28  ASN A CB  1 
ATOM   200  C CG  . ASN A 1 28  ? 9.53348  -8.44276  -12.34655 1.000 16.47451  ? 28  ASN A CG  1 
ATOM   201  O OD1 . ASN A 1 28  ? 8.55341  -7.78915  -12.69360 1.000 16.44216  ? 28  ASN A OD1 1 
ATOM   202  N ND2 . ASN A 1 28  ? 9.63881  -9.76486  -12.54458 1.000 17.88415  ? 28  ASN A ND2 1 
ATOM   203  N N   . GLY A 1 29  ? 12.51887 -5.26867  -11.07897 1.000 16.86651  ? 29  GLY A N   1 
ATOM   204  C CA  . GLY A 1 29  ? 13.49454 -4.74816  -10.14815 1.000 19.54579  ? 29  GLY A CA  1 
ATOM   205  C C   . GLY A 1 29  ? 12.83926 -4.38560  -8.82620  1.000 17.79805  ? 29  GLY A C   1 
ATOM   206  O O   . GLY A 1 29  ? 11.61478 -4.28899  -8.72533  1.000 18.76462  ? 29  GLY A O   1 
ATOM   207  N N   . LEU A 1 30  ? 13.68572 -4.11437  -7.82871  1.000 13.83785  ? 30  LEU A N   1 
ATOM   208  C CA  . LEU A 1 30  ? 13.24230 -3.79392  -6.47254  1.000 16.52538  ? 30  LEU A CA  1 
ATOM   209  C C   . LEU A 1 30  ? 13.69247 -2.38298  -6.12701  1.000 19.32614  ? 30  LEU A C   1 
ATOM   210  O O   . LEU A 1 30  ? 14.89517 -2.12607  -5.96671  1.000 17.85291  ? 30  LEU A O   1 
ATOM   211  C CB  . LEU A 1 30  ? 13.78458 -4.79950  -5.43897  1.000 15.61986  ? 30  LEU A CB  1 
ATOM   212  C CG  . LEU A 1 30  ? 13.29089 -4.62230  -3.99298  1.000 13.54839  ? 30  LEU A CG  1 
ATOM   213  C CD1 . LEU A 1 30  ? 11.79137 -5.00923  -3.95831  1.000 14.53255  ? 30  LEU A CD1 1 
ATOM   214  C CD2 . LEU A 1 30  ? 14.08456 -5.40357  -2.89417  1.000 13.84285  ? 30  LEU A CD2 1 
ATOM   215  N N   . TRP A 1 31  ? 12.72490 -1.48123  -5.95418  1.000 16.46170  ? 31  TRP A N   1 
ATOM   216  C CA  . TRP A 1 31  ? 12.98645 -0.04893  -5.76729  1.000 17.26540  ? 31  TRP A CA  1 
ATOM   217  C C   . TRP A 1 31  ? 12.95897 0.28833   -4.26839  1.000 16.84111  ? 31  TRP A C   1 
ATOM   218  O O   . TRP A 1 31  ? 11.90308 0.27098   -3.63973  1.000 16.88151  ? 31  TRP A O   1 
ATOM   219  C CB  . TRP A 1 31  ? 11.93952 0.73740   -6.56130  1.000 22.05294  ? 31  TRP A CB  1 
ATOM   220  C CG  . TRP A 1 31  ? 12.09731 2.24006   -6.59482  1.000 17.76798  ? 31  TRP A CG  1 
ATOM   221  C CD1 . TRP A 1 31  ? 13.23466 2.95856   -6.37485  1.000 27.01259  ? 31  TRP A CD1 1 
ATOM   222  C CD2 . TRP A 1 31  ? 11.06088 3.20375   -6.88593  1.000 20.69782  ? 31  TRP A CD2 1 
ATOM   223  N NE1 . TRP A 1 31  ? 12.96649 4.32144   -6.49792  1.000 24.82996  ? 31  TRP A NE1 1 
ATOM   224  C CE2 . TRP A 1 31  ? 11.64258 4.48591   -6.81236  1.000 27.12305  ? 31  TRP A CE2 1 
ATOM   225  C CE3 . TRP A 1 31  ? 9.70052  3.09861   -7.18356  1.000 30.70170  ? 31  TRP A CE3 1 
ATOM   226  C CZ2 . TRP A 1 31  ? 10.91147 5.65568   -7.04111  1.000 29.69007  ? 31  TRP A CZ2 1 
ATOM   227  C CZ3 . TRP A 1 31  ? 8.97739  4.25604   -7.41030  1.000 26.54719  ? 31  TRP A CZ3 1 
ATOM   228  C CH2 . TRP A 1 31  ? 9.58611  5.51928   -7.32913  1.000 28.37273  ? 31  TRP A CH2 1 
ATOM   229  N N   . LEU A 1 32  ? 14.13519 0.54891   -3.67371  1.000 14.33919  ? 32  LEU A N   1 
ATOM   230  C CA  . LEU A 1 32  ? 14.21603 0.92290   -2.26704  1.000 15.32624  ? 32  LEU A CA  1 
ATOM   231  C C   . LEU A 1 32  ? 14.99981 2.22355   -2.18808  1.000 19.83172  ? 32  LEU A C   1 
ATOM   232  O O   . LEU A 1 32  ? 16.11675 2.28115   -2.69768  1.000 21.17487  ? 32  LEU A O   1 
ATOM   233  C CB  . LEU A 1 32  ? 14.91170 -0.16954  -1.44818  1.000 16.08888  ? 32  LEU A CB  1 
ATOM   234  C CG  . LEU A 1 32  ? 14.19325 -1.53042  -1.41511  1.000 13.47997  ? 32  LEU A CG  1 
ATOM   235  C CD1 . LEU A 1 32  ? 15.21331 -2.54293  -0.85614  1.000 13.51624  ? 32  LEU A CD1 1 
ATOM   236  C CD2 . LEU A 1 32  ? 12.94018 -1.47506  -0.59286  1.000 17.02599  ? 32  LEU A CD2 1 
ATOM   237  N N   . ASP A 1 33  ? 14.39626 3.25905   -1.60166  1.000 20.03310  ? 33  ASP A N   1 
ATOM   238  C CA  . ASP A 1 33  ? 14.99562 4.61634   -1.57829  1.000 21.38169  ? 33  ASP A CA  1 
ATOM   239  C C   . ASP A 1 33  ? 15.30781 4.97569   -3.03138  1.000 19.84767  ? 33  ASP A C   1 
ATOM   240  O O   . ASP A 1 33  ? 14.47072 4.76627   -3.92278  1.000 22.38378  ? 33  ASP A O   1 
ATOM   241  C CB  . ASP A 1 33  ? 16.18885 4.62801   -0.63081  1.000 24.98816  ? 33  ASP A CB  1 
ATOM   242  C CG  . ASP A 1 33  ? 15.82591 4.22129   0.78687   1.000 29.67727  ? 33  ASP A CG  1 
ATOM   243  O OD1 . ASP A 1 33  ? 14.88965 4.79626   1.36212   1.000 31.08205  ? 33  ASP A OD1 1 
ATOM   244  O OD2 . ASP A 1 33  ? 16.51527 3.33789   1.35397   1.000 36.87557  ? 33  ASP A OD2 1 
ATOM   245  N N   . ASP A 1 34  ? 16.49553 5.49006   -3.35019  1.000 22.89584  ? 34  ASP A N   1 
ATOM   246  C CA  . ASP A 1 34  ? 16.74258 5.89915   -4.72512  1.000 25.39200  ? 34  ASP A CA  1 
ATOM   247  C C   . ASP A 1 34  ? 17.54886 4.85960   -5.51148  1.000 27.79476  ? 34  ASP A C   1 
ATOM   248  O O   . ASP A 1 34  ? 18.29981 5.20426   -6.43191  1.000 23.19598  ? 34  ASP A O   1 
ATOM   249  C CB  . ASP A 1 34  ? 17.40250 7.28854   -4.73053  1.000 28.58397  ? 34  ASP A CB  1 
ATOM   250  C CG  . ASP A 1 34  ? 18.77307 7.30204   -4.09598  1.000 38.62843  ? 34  ASP A CG  1 
ATOM   251  O OD1 . ASP A 1 34  ? 19.09769 6.36886   -3.31191  1.000 29.83972  ? 34  ASP A OD1 1 
ATOM   252  O OD2 . ASP A 1 34  ? 19.51576 8.29520   -4.34680  1.000 27.28957  ? 34  ASP A OD2 1 
ATOM   253  N N   . VAL A 1 35  ? 17.38691 3.56928   -5.19725  1.000 21.13620  ? 35  VAL A N   1 
ATOM   254  C CA  . VAL A 1 35  ? 18.13837 2.52125   -5.87810  1.000 20.76723  ? 35  VAL A CA  1 
ATOM   255  C C   . VAL A 1 35  ? 17.18424 1.43196   -6.34755  1.000 21.57276  ? 35  VAL A C   1 
ATOM   256  O O   . VAL A 1 35  ? 16.25756 1.06163   -5.61734  1.000 20.06552  ? 35  VAL A O   1 
ATOM   257  C CB  . VAL A 1 35  ? 19.22015 1.91731   -4.96160  1.000 22.74704  ? 35  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 35  ? 19.92611 0.77410   -5.68057  1.000 14.29972  ? 35  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 35  ? 20.22785 3.02308   -4.54671  1.000 24.18440  ? 35  VAL A CG2 1 
ATOM   260  N N   . VAL A 1 36  ? 17.42950 0.90824   -7.54989  1.000 17.64786  ? 36  VAL A N   1 
ATOM   261  C CA  . VAL A 1 36  ? 16.66699 -0.20694  -8.09349  1.000 23.19601  ? 36  VAL A CA  1 
ATOM   262  C C   . VAL A 1 36  ? 17.61589 -1.38411  -8.25042  1.000 20.24148  ? 36  VAL A C   1 
ATOM   263  O O   . VAL A 1 36  ? 18.63632 -1.29449  -8.94461  1.000 19.51539  ? 36  VAL A O   1 
ATOM   264  C CB  . VAL A 1 36  ? 15.98324 0.16612   -9.41785  1.000 23.07905  ? 36  VAL A CB  1 
ATOM   265  C CG1 . VAL A 1 36  ? 15.28319 -1.05373  -10.04143 1.000 20.57613  ? 36  VAL A CG1 1 
ATOM   266  C CG2 . VAL A 1 36  ? 14.99593 1.31450   -9.15025  1.000 18.49741  ? 36  VAL A CG2 1 
ATOM   267  N N   . TYR A 1 37  ? 17.28816 -2.49214  -7.58848  1.000 15.60514  ? 37  TYR A N   1 
ATOM   268  C CA  . TYR A 1 37  ? 18.07665 -3.71246  -7.61498  1.000 14.61573  ? 37  TYR A CA  1 
ATOM   269  C C   . TYR A 1 37  ? 17.47001 -4.70197  -8.60100  1.000 17.93511  ? 37  TYR A C   1 
ATOM   270  O O   . TYR A 1 37  ? 16.25524 -4.89237  -8.59652  1.000 20.80780  ? 37  TYR A O   1 
ATOM   271  C CB  . TYR A 1 37  ? 18.10468 -4.33109  -6.21242  1.000 12.53409  ? 37  TYR A CB  1 
ATOM   272  C CG  . TYR A 1 37  ? 18.61747 -3.41441  -5.11773  1.000 18.96793  ? 37  TYR A CG  1 
ATOM   273  C CD1 . TYR A 1 37  ? 17.81599 -2.41116  -4.57999  1.000 13.77683  ? 37  TYR A CD1 1 
ATOM   274  C CD2 . TYR A 1 37  ? 19.92977 -3.52193  -4.67608  1.000 17.85521  ? 37  TYR A CD2 1 
ATOM   275  C CE1 . TYR A 1 37  ? 18.27567 -1.56934  -3.58954  1.000 17.57550  ? 37  TYR A CE1 1 
ATOM   276  C CE2 . TYR A 1 37  ? 20.42008 -2.68865  -3.67909  1.000 17.87770  ? 37  TYR A CE2 1 
ATOM   277  C CZ  . TYR A 1 37  ? 19.61901 -1.71657  -3.15973  1.000 16.56633  ? 37  TYR A CZ  1 
ATOM   278  O OH  . TYR A 1 37  ? 20.08983 -0.88860  -2.20617  1.000 18.87584  ? 37  TYR A OH  1 
ATOM   279  N N   . CYS A 1 38  ? 18.29502 -5.34870  -9.42039  1.000 17.19867  ? 38  CYS A N   1 
ATOM   280  C CA  . CYS A 1 38  ? 17.74370 -6.31631  -10.36410 1.000 14.69886  ? 38  CYS A CA  1 
ATOM   281  C C   . CYS A 1 38  ? 18.83985 -7.28302  -10.78835 1.000 17.81810  ? 38  CYS A C   1 
ATOM   282  O O   . CYS A 1 38  ? 20.02597 -7.03450  -10.53776 1.000 15.53297  ? 38  CYS A O   1 
ATOM   283  C CB  . CYS A 1 38  ? 17.10404 -5.61635  -11.58309 1.000 17.91067  ? 38  CYS A CB  1 
ATOM   284  S SG  . CYS A 1 38  ? 18.32947 -4.95963  -12.73572 1.000 21.29979  ? 38  CYS A SG  1 
ATOM   285  N N   . PRO A 1 39  ? 18.47470 -8.41199  -11.40249 1.000 16.22414  ? 39  PRO A N   1 
ATOM   286  C CA  . PRO A 1 39  ? 19.48856 -9.37216  -11.85012 1.000 12.08875  ? 39  PRO A CA  1 
ATOM   287  C C   . PRO A 1 39  ? 20.36342 -8.75042  -12.92539 1.000 18.31259  ? 39  PRO A C   1 
ATOM   288  O O   . PRO A 1 39  ? 19.86940 -8.07132  -13.83392 1.000 19.44346  ? 39  PRO A O   1 
ATOM   289  C CB  . PRO A 1 39  ? 18.65853 -10.52353 -12.42492 1.000 14.53839  ? 39  PRO A CB  1 
ATOM   290  C CG  . PRO A 1 39  ? 17.30872 -10.39503 -11.63238 1.000 12.01574  ? 39  PRO A CG  1 
ATOM   291  C CD  . PRO A 1 39  ? 17.09493 -8.93856  -11.54857 1.000 14.95493  ? 39  PRO A CD  1 
ATOM   292  N N   . ARG A 1 40  ? 21.65746 -9.00754  -12.83490 1.000 15.05845  ? 40  ARG A N   1 
ATOM   293  C CA  . ARG A 1 40  ? 22.54031 -8.38014  -13.81833 1.000 17.92967  ? 40  ARG A CA  1 
ATOM   294  C C   . ARG A 1 40  ? 22.35965 -8.99943  -15.19434 1.000 25.84578  ? 40  ARG A C   1 
ATOM   295  O O   . ARG A 1 40  ? 22.73681 -8.36230  -16.19403 1.000 17.47558  ? 40  ARG A O   1 
ATOM   296  C CB  . ARG A 1 40  ? 23.99974 -8.43246  -13.36094 1.000 12.54710  ? 40  ARG A CB  1 
ATOM   297  C CG  . ARG A 1 40  ? 24.60268 -9.80667  -13.36327 1.000 11.57072  ? 40  ARG A CG  1 
ATOM   298  C CD  . ARG A 1 40  ? 26.10088 -9.79540  -12.97730 1.000 13.27713  ? 40  ARG A CD  1 
ATOM   299  N NE  . ARG A 1 40  ? 26.65853 -11.14538 -12.95539 1.000 14.44536  ? 40  ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 40  ? 27.94321 -11.41733 -12.76562 1.000 17.20698  ? 40  ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 40  ? 28.84199 -10.44587 -12.60313 1.000 20.94360  ? 40  ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 40  ? 28.36220 -12.68069 -12.84349 1.000 15.53856  ? 40  ARG A NH2 1 
ATOM   303  N N   . HIS A 1 41  ? 21.71340 -10.18177 -15.29031 1.000 18.47823  ? 41  HIS A N   1 
ATOM   304  C CA  . HIS A 1 41  ? 21.56823 -10.74719 -16.63345 1.000 17.26383  ? 41  HIS A CA  1 
ATOM   305  C C   . HIS A 1 41  ? 20.58026 -9.95724  -17.49112 1.000 19.01028  ? 41  HIS A C   1 
ATOM   306  O O   . HIS A 1 41  ? 20.45763 -10.27687 -18.67025 1.000 25.50366  ? 41  HIS A O   1 
ATOM   307  C CB  . HIS A 1 41  ? 21.26782 -12.27047 -16.58321 1.000 21.01378  ? 41  HIS A CB  1 
ATOM   308  C CG  . HIS A 1 41  ? 19.90258 -12.67611 -16.09094 1.000 20.92998  ? 41  HIS A CG  1 
ATOM   309  N ND1 . HIS A 1 41  ? 18.73079 -12.40190 -16.77114 1.000 22.59597  ? 41  HIS A ND1 1 
ATOM   310  C CD2 . HIS A 1 41  ? 19.53735 -13.39547 -14.99747 1.000 20.54225  ? 41  HIS A CD2 1 
ATOM   311  C CE1 . HIS A 1 41  ? 17.70230 -12.91185 -16.10513 1.000 25.24266  ? 41  HIS A CE1 1 
ATOM   312  N NE2 . HIS A 1 41  ? 18.16541 -13.52670 -15.02819 1.000 16.95373  ? 41  HIS A NE2 1 
ATOM   313  N N   . VAL A 1 42  ? 19.94449 -8.90995  -16.95740 1.000 17.07924  ? 42  VAL A N   1 
ATOM   314  C CA  . VAL A 1 42  ? 19.14259 -8.00531  -17.79553 1.000 19.98169  ? 42  VAL A CA  1 
ATOM   315  C C   . VAL A 1 42  ? 19.99661 -7.36681  -18.90123 1.000 25.11320  ? 42  VAL A C   1 
ATOM   316  O O   . VAL A 1 42  ? 19.45778 -6.94584  -19.93837 1.000 24.00575  ? 42  VAL A O   1 
ATOM   317  C CB  . VAL A 1 42  ? 18.46519 -6.89220  -16.95634 1.000 12.91398  ? 42  VAL A CB  1 
ATOM   318  C CG1 . VAL A 1 42  ? 19.50881 -5.90934  -16.40319 1.000 22.26693  ? 42  VAL A CG1 1 
ATOM   319  C CG2 . VAL A 1 42  ? 17.26995 -6.14555  -17.72990 1.000 16.17386  ? 42  VAL A CG2 1 
ATOM   320  N N   . ILE A 1 43  ? 21.31698 -7.24444  -18.69762 1.000 25.34955  ? 43  ILE A N   1 
ATOM   321  C CA  . ILE A 1 43  ? 22.15647 -6.53019  -19.67156 1.000 27.40215  ? 43  ILE A CA  1 
ATOM   322  C C   . ILE A 1 43  ? 22.61205 -7.46376  -20.77900 1.000 26.29927  ? 43  ILE A C   1 
ATOM   323  O O   . ILE A 1 43  ? 23.44176 -7.09454  -21.62079 1.000 35.37155  ? 43  ILE A O   1 
ATOM   324  C CB  . ILE A 1 43  ? 23.37718 -5.86489  -19.01010 1.000 19.79874  ? 43  ILE A CB  1 
ATOM   325  C CG1 . ILE A 1 43  ? 24.40078 -6.89343  -18.50856 1.000 25.87479  ? 43  ILE A CG1 1 
ATOM   326  C CG2 . ILE A 1 43  ? 22.92920 -4.92886  -17.94856 1.000 22.69683  ? 43  ILE A CG2 1 
ATOM   327  C CD1 . ILE A 1 43  ? 25.65570 -6.24076  -17.91752 1.000 20.05279  ? 43  ILE A CD1 1 
ATOM   328  N N   . CYS A 1 44  ? 22.08087 -8.67575  -20.78517 1.000 30.39640  ? 44  CYS A N   1 
ATOM   329  C CA  . CYS A 1 44  ? 22.54729 -9.74732  -21.64520 1.000 32.48414  ? 44  CYS A CA  1 
ATOM   330  C C   . CYS A 1 44  ? 21.58342 -9.92616  -22.80528 1.000 34.27001  ? 44  CYS A C   1 
ATOM   331  O O   . CYS A 1 44  ? 20.36949 -10.03220 -22.59780 1.000 50.99249  ? 44  CYS A O   1 
ATOM   332  C CB  . CYS A 1 44  ? 22.61500 -11.06116 -20.87495 1.000 37.89384  ? 44  CYS A CB  1 
ATOM   333  S SG  . CYS A 1 44  ? 24.03716 -11.26172 -19.86621 1.000 44.72183  ? 44  CYS A SG  1 
ATOM   334  N N   . THR A 1 45  ? 22.12242 -9.98257  -24.01429 1.000 49.73458  ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? 21.38026 -10.56767 -25.11624 1.000 57.58412  ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? 21.49432 -12.07907 -24.99427 1.000 58.75638  ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? 22.45346 -12.59438 -24.41122 1.000 61.27559  ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? 21.92905 -10.09155 -26.46838 1.000 62.39109  ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? 23.24749 -10.62048 -26.67167 1.000 55.20422  ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? 22.01355 -8.57396  -26.51048 1.000 42.63950  ? 45  THR A CG2 1 
ATOM   341  N N   . SER A 1 46  ? 20.50170 -12.79322 -25.53233 1.000 57.18551  ? 46  SER A N   1 
ATOM   342  C CA  . SER A 1 46  ? 20.55019 -14.25517 -25.49791 1.000 69.94600  ? 46  SER A CA  1 
ATOM   343  C C   . SER A 1 46  ? 21.85633 -14.79289 -26.08096 1.000 69.68836  ? 46  SER A C   1 
ATOM   344  O O   . SER A 1 46  ? 22.37501 -15.81860 -25.61944 1.000 68.62546  ? 46  SER A O   1 
ATOM   345  C CB  . SER A 1 46  ? 19.34755 -14.83341 -26.24682 1.000 65.73210  ? 46  SER A CB  1 
ATOM   346  O OG  . SER A 1 46  ? 18.71398 -13.83878 -27.03363 1.000 62.41217  ? 46  SER A OG  1 
ATOM   347  N N   . GLU A 1 47  ? 22.41123 -14.09677 -27.07656 1.000 73.17669  ? 47  GLU A N   1 
ATOM   348  C CA  . GLU A 1 47  ? 23.69828 -14.45549 -27.65834 1.000 62.46787  ? 47  GLU A CA  1 
ATOM   349  C C   . GLU A 1 47  ? 24.84546 -14.32651 -26.65820 1.000 60.55577  ? 47  GLU A C   1 
ATOM   350  O O   . GLU A 1 47  ? 25.88949 -14.96105 -26.84212 1.000 62.64485  ? 47  GLU A O   1 
ATOM   351  C CB  . GLU A 1 47  ? 23.97530 -13.57845 -28.88941 1.000 63.90958  ? 47  GLU A CB  1 
ATOM   352  C CG  . GLU A 1 47  ? 22.83116 -13.48640 -29.92073 1.000 69.60138  ? 47  GLU A CG  1 
ATOM   353  C CD  . GLU A 1 47  ? 21.62545 -12.66472 -29.44382 1.000 82.72822  ? 47  GLU A CD  1 
ATOM   354  O OE1 . GLU A 1 47  ? 20.69224 -13.26474 -28.85813 1.000 80.93801  ? 47  GLU A OE1 1 
ATOM   355  O OE2 . GLU A 1 47  ? 21.60567 -11.42678 -29.65665 1.000 69.80405  ? 47  GLU A OE2 1 
ATOM   356  N N   . ASP A 1 48  ? 24.68262 -13.52618 -25.60675 1.000 65.40775  ? 48  ASP A N   1 
ATOM   357  C CA  . ASP A 1 48  ? 25.73581 -13.31402 -24.61925 1.000 69.96598  ? 48  ASP A CA  1 
ATOM   358  C C   . ASP A 1 48  ? 25.76900 -14.36370 -23.50991 1.000 64.54145  ? 48  ASP A C   1 
ATOM   359  O O   . ASP A 1 48  ? 26.57606 -14.22098 -22.59078 1.000 59.99814  ? 48  ASP A O   1 
ATOM   360  C CB  . ASP A 1 48  ? 25.60269 -11.92632 -23.97014 1.000 50.83742  ? 48  ASP A CB  1 
ATOM   361  C CG  . ASP A 1 48  ? 25.81223 -10.78591 -24.95436 1.000 70.13750  ? 48  ASP A CG  1 
ATOM   362  O OD1 . ASP A 1 48  ? 26.87123 -10.77400 -25.62719 1.000 65.80339  ? 48  ASP A OD1 1 
ATOM   363  O OD2 . ASP A 1 48  ? 24.92873 -9.89660  -25.04340 1.000 64.54438  ? 48  ASP A OD2 1 
ATOM   364  N N   . MET A 1 49  ? 24.94712 -15.41879 -23.57255 1.000 64.60824  ? 49  MET A N   1 
ATOM   365  C CA  . MET A 1 49  ? 24.66858 -16.18313 -22.35825 1.000 61.43665  ? 49  MET A CA  1 
ATOM   366  C C   . MET A 1 49  ? 25.60031 -17.36022 -22.08879 1.000 61.32266  ? 49  MET A C   1 
ATOM   367  O O   . MET A 1 49  ? 25.69770 -17.77317 -20.92998 1.000 64.18209  ? 49  MET A O   1 
ATOM   368  C CB  . MET A 1 49  ? 23.22308 -16.69566 -22.34484 1.000 50.23854  ? 49  MET A CB  1 
ATOM   369  C CG  . MET A 1 49  ? 22.20288 -15.69400 -21.80805 1.000 49.64268  ? 49  MET A CG  1 
ATOM   370  S SD  . MET A 1 49  ? 22.90757 -14.48747 -20.63359 1.000 64.67767  ? 49  MET A SD  1 
ATOM   371  C CE  . MET A 1 49  ? 22.72113 -15.24623 -19.01134 1.000 37.46036  ? 49  MET A CE  1 
ATOM   372  N N   . PHE A 1 50  ? 26.28900 -17.93113 -23.07682 1.000 57.76572  ? 50  PHE A N   1 
ATOM   373  C CA  . PHE A 1 50  ? 27.04393 -19.13338 -22.73107 1.000 60.69390  ? 50  PHE A CA  1 
ATOM   374  C C   . PHE A 1 50  ? 28.22521 -18.79795 -21.80715 1.000 66.54153  ? 50  PHE A C   1 
ATOM   375  O O   . PHE A 1 50  ? 28.50638 -19.55003 -20.85896 1.000 54.83412  ? 50  PHE A O   1 
ATOM   376  C CB  . PHE A 1 50  ? 27.51799 -19.88953 -23.97919 1.000 39.74000  ? 50  PHE A CB  1 
ATOM   377  C CG  . PHE A 1 50  ? 28.45852 -21.02885 -23.65641 1.000 64.04772  ? 50  PHE A CG  1 
ATOM   378  C CD1 . PHE A 1 50  ? 27.97229 -22.20274 -23.08370 1.000 56.48002  ? 50  PHE A CD1 1 
ATOM   379  C CD2 . PHE A 1 50  ? 29.83217 -20.90526 -23.85638 1.000 70.46979  ? 50  PHE A CD2 1 
ATOM   380  C CE1 . PHE A 1 50  ? 28.83179 -23.24816 -22.74377 1.000 57.84704  ? 50  PHE A CE1 1 
ATOM   381  C CE2 . PHE A 1 50  ? 30.70222 -21.94413 -23.52151 1.000 69.18318  ? 50  PHE A CE2 1 
ATOM   382  C CZ  . PHE A 1 50  ? 30.19857 -23.11764 -22.96527 1.000 72.67572  ? 50  PHE A CZ  1 
ATOM   383  N N   . ASN A 1 51  ? 28.90802 -17.66239 -22.03542 1.000 48.53431  ? 51  ASN A N   1 
ATOM   384  C CA  . ASN A 1 51  ? 30.01312 -17.23081 -21.16967 1.000 46.67981  ? 51  ASN A CA  1 
ATOM   385  C C   . ASN A 1 51  ? 30.08177 -15.70452 -21.06725 1.000 52.08145  ? 51  ASN A C   1 
ATOM   386  O O   . ASN A 1 51  ? 31.07084 -15.08641 -21.48290 1.000 43.37707  ? 51  ASN A O   1 
ATOM   387  C CB  . ASN A 1 51  ? 31.34137 -17.78018 -21.68969 1.000 56.70131  ? 51  ASN A CB  1 
ATOM   388  C CG  . ASN A 1 51  ? 32.18377 -18.39284 -20.59815 1.000 57.87757  ? 51  ASN A CG  1 
ATOM   389  O OD1 . ASN A 1 51  ? 32.40215 -17.77814 -19.55222 1.000 63.20159  ? 51  ASN A OD1 1 
ATOM   390  N ND2 . ASN A 1 51  ? 32.70510 -19.58760 -20.85144 1.000 53.62205  ? 51  ASN A ND2 1 
ATOM   391  N N   . PRO A 1 52  ? 29.06683 -15.06792 -20.46282 1.000 46.13157  ? 52  PRO A N   1 
ATOM   392  C CA  . PRO A 1 52  ? 29.03401 -13.59497 -20.45140 1.000 35.10618  ? 52  PRO A CA  1 
ATOM   393  C C   . PRO A 1 52  ? 30.21998 -13.05390 -19.67821 1.000 37.90706  ? 52  PRO A C   1 
ATOM   394  O O   . PRO A 1 52  ? 30.59675 -13.60244 -18.64244 1.000 38.93785  ? 52  PRO A O   1 
ATOM   395  C CB  . PRO A 1 52  ? 27.74161 -13.26383 -19.70039 1.000 42.35310  ? 52  PRO A CB  1 
ATOM   396  C CG  . PRO A 1 52  ? 26.93490 -14.48649 -19.67277 1.000 44.71716  ? 52  PRO A CG  1 
ATOM   397  C CD  . PRO A 1 52  ? 27.75573 -15.64830 -20.14124 1.000 44.20786  ? 52  PRO A CD  1 
ATOM   398  N N   . ASN A 1 53  ? 30.81273 -11.96577 -20.15844 1.000 31.82538  ? 53  ASN A N   1 
ATOM   399  C CA  . ASN A 1 53  ? 31.71029 -11.21167 -19.29247 1.000 31.92343  ? 53  ASN A CA  1 
ATOM   400  C C   . ASN A 1 53  ? 30.92514 -9.95921  -18.93435 1.000 38.81062  ? 53  ASN A C   1 
ATOM   401  O O   . ASN A 1 53  ? 30.79787 -9.04435  -19.75496 1.000 35.01838  ? 53  ASN A O   1 
ATOM   402  C CB  . ASN A 1 53  ? 33.05113 -10.84755 -19.91494 1.000 39.30441  ? 53  ASN A CB  1 
ATOM   403  C CG  . ASN A 1 53  ? 33.97135 -10.20231 -18.89106 1.000 32.74779  ? 53  ASN A CG  1 
ATOM   404  O OD1 . ASN A 1 53  ? 34.02355 -8.97760  -18.76790 1.000 40.13238  ? 53  ASN A OD1 1 
ATOM   405  N ND2 . ASN A 1 53  ? 34.70928 -11.02840 -18.14637 1.000 44.03513  ? 53  ASN A ND2 1 
ATOM   406  N N   . TYR A 1 54  ? 30.38625 -9.93031  -17.70826 1.000 28.75744  ? 54  TYR A N   1 
ATOM   407  C CA  . TYR A 1 54  ? 29.46736 -8.86173  -17.33742 1.000 28.84027  ? 54  TYR A CA  1 
ATOM   408  C C   . TYR A 1 54  ? 30.19164 -7.53743  -17.14198 1.000 32.83301  ? 54  TYR A C   1 
ATOM   409  O O   . TYR A 1 54  ? 29.61034 -6.46886  -17.38677 1.000 23.58073  ? 54  TYR A O   1 
ATOM   410  C CB  . TYR A 1 54  ? 28.71372 -9.23209  -16.04978 1.000 25.38295  ? 54  TYR A CB  1 
ATOM   411  C CG  . TYR A 1 54  ? 27.68657 -10.31821 -16.23304 1.000 26.40100  ? 54  TYR A CG  1 
ATOM   412  C CD1 . TYR A 1 54  ? 26.39913 -10.02475 -16.64163 1.000 25.05321  ? 54  TYR A CD1 1 
ATOM   413  C CD2 . TYR A 1 54  ? 28.02666 -11.64405 -16.00759 1.000 23.89769  ? 54  TYR A CD2 1 
ATOM   414  C CE1 . TYR A 1 54  ? 25.46221 -11.01470 -16.78560 1.000 24.38803  ? 54  TYR A CE1 1 
ATOM   415  C CE2 . TYR A 1 54  ? 27.13746 -12.63522 -16.17870 1.000 18.16680  ? 54  TYR A CE2 1 
ATOM   416  C CZ  . TYR A 1 54  ? 25.83219 -12.32179 -16.56679 1.000 17.73478  ? 54  TYR A CZ  1 
ATOM   417  O OH  . TYR A 1 54  ? 24.91644 -13.33624 -16.73275 1.000 22.99421  ? 54  TYR A OH  1 
ATOM   418  N N   . GLU A 1 55  ? 31.42969 -7.57734  -16.65073 1.000 29.62406  ? 55  GLU A N   1 
ATOM   419  C CA  . GLU A 1 55  ? 32.17906 -6.33687  -16.52773 1.000 30.98086  ? 55  GLU A CA  1 
ATOM   420  C C   . GLU A 1 55  ? 32.30239 -5.68078  -17.90208 1.000 33.19674  ? 55  GLU A C   1 
ATOM   421  O O   . GLU A 1 55  ? 32.02493 -4.48821  -18.05553 1.000 26.24468  ? 55  GLU A O   1 
ATOM   422  C CB  . GLU A 1 55  ? 33.55072 -6.61615  -15.89519 1.000 34.68287  ? 55  GLU A CB  1 
ATOM   423  C CG  . GLU A 1 55  ? 34.42922 -5.35905  -15.67448 1.000 54.75282  ? 55  GLU A CG  1 
ATOM   424  C CD  . GLU A 1 55  ? 35.69514 -5.61398  -14.82150 1.000 66.86670  ? 55  GLU A CD  1 
ATOM   425  O OE1 . GLU A 1 55  ? 35.99438 -6.78910  -14.51062 1.000 60.38085  ? 55  GLU A OE1 1 
ATOM   426  O OE2 . GLU A 1 55  ? 36.39894 -4.63576  -14.46907 1.000 56.10289  ? 55  GLU A OE2 1 
ATOM   427  N N   . ASP A 1 56  ? 32.61577 -6.48111  -18.92850 1.000 31.24396  ? 56  ASP A N   1 
ATOM   428  C CA  . ASP A 1 56  ? 32.64815 -5.98884  -20.30650 1.000 38.20544  ? 56  ASP A CA  1 
ATOM   429  C C   . ASP A 1 56  ? 31.28482 -5.50505  -20.77521 1.000 44.68370  ? 56  ASP A C   1 
ATOM   430  O O   . ASP A 1 56  ? 31.16252 -4.40114  -21.32632 1.000 36.26490  ? 56  ASP A O   1 
ATOM   431  C CB  . ASP A 1 56  ? 33.14866 -7.08080  -21.25156 1.000 44.25928  ? 56  ASP A CB  1 
ATOM   432  C CG  . ASP A 1 56  ? 34.49504 -6.77914  -21.81895 1.000 44.16717  ? 56  ASP A CG  1 
ATOM   433  O OD1 . ASP A 1 56  ? 35.21723 -5.95203  -21.23645 1.000 39.84549  ? 56  ASP A OD1 1 
ATOM   434  O OD2 . ASP A 1 56  ? 34.79828 -7.32675  -22.89371 1.000 61.43547  ? 56  ASP A OD2 1 
ATOM   435  N N   . LEU A 1 57  ? 30.24758 -6.34018  -20.62120 1.000 28.10663  ? 57  LEU A N   1 
ATOM   436  C CA  . LEU A 1 57  ? 28.94187 -5.92219  -21.11732 1.000 36.18186  ? 57  LEU A CA  1 
ATOM   437  C C   . LEU A 1 57  ? 28.45921 -4.66104  -20.42639 1.000 28.53830  ? 57  LEU A C   1 
ATOM   438  O O   . LEU A 1 57  ? 27.71411 -3.87398  -21.02400 1.000 36.16581  ? 57  LEU A O   1 
ATOM   439  C CB  . LEU A 1 57  ? 27.90756 -7.04954  -20.98555 1.000 27.66333  ? 57  LEU A CB  1 
ATOM   440  C CG  . LEU A 1 57  ? 28.22907 -8.38664  -21.63054 1.000 32.29938  ? 57  LEU A CG  1 
ATOM   441  C CD1 . LEU A 1 57  ? 27.30451 -9.45061  -21.08588 1.000 38.83235  ? 57  LEU A CD1 1 
ATOM   442  C CD2 . LEU A 1 57  ? 27.99464 -8.26355  -23.13726 1.000 40.06599  ? 57  LEU A CD2 1 
ATOM   443  N N   . LEU A 1 58  ? 28.86483 -4.44738  -19.17582 1.000 27.16853  ? 58  LEU A N   1 
ATOM   444  C CA  . LEU A 1 58  ? 28.36613 -3.28540  -18.45046 1.000 24.59044  ? 58  LEU A CA  1 
ATOM   445  C C   . LEU A 1 58  ? 29.14792 -2.01082  -18.79645 1.000 21.14474  ? 58  LEU A C   1 
ATOM   446  O O   . LEU A 1 58  ? 28.55379 -0.93512  -18.87435 1.000 24.68693  ? 58  LEU A O   1 
ATOM   447  C CB  . LEU A 1 58  ? 28.39430 -3.55070  -16.93270 1.000 23.12618  ? 58  LEU A CB  1 
ATOM   448  C CG  . LEU A 1 58  ? 27.73462 -2.45119  -16.08629 1.000 32.27459  ? 58  LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 58  ? 26.29812 -2.13463  -16.48817 1.000 30.89608  ? 58  LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 58  ? 27.82564 -2.72410  -14.58871 1.000 30.65306  ? 58  LEU A CD2 1 
ATOM   451  N N   . ILE A 1 59  ? 30.47124 -2.10043  -18.96719 1.000 31.07474  ? 59  ILE A N   1 
ATOM   452  C CA  . ILE A 1 59  ? 31.24268 -0.91462  -19.36378 1.000 24.78338  ? 59  ILE A CA  1 
ATOM   453  C C   . ILE A 1 59  ? 30.74314 -0.35645  -20.68882 1.000 35.06494  ? 59  ILE A C   1 
ATOM   454  O O   . ILE A 1 59  ? 30.87079 0.84909   -20.94451 1.000 30.99386  ? 59  ILE A O   1 
ATOM   455  C CB  . ILE A 1 59  ? 32.75874 -1.25248  -19.39736 1.000 30.44630  ? 59  ILE A CB  1 
ATOM   456  C CG1 . ILE A 1 59  ? 33.60658 0.00342   -19.20247 1.000 37.21599  ? 59  ILE A CG1 1 
ATOM   457  C CG2 . ILE A 1 59  ? 33.13592 -1.95935  -20.69463 1.000 39.38708  ? 59  ILE A CG2 1 
ATOM   458  C CD1 . ILE A 1 59  ? 33.62703 0.52493   -17.79086 1.000 40.22349  ? 59  ILE A CD1 1 
ATOM   459  N N   . ARG A 1 60  ? 30.12310 -1.19739  -21.51935 1.000 30.30839  ? 60  ARG A N   1 
ATOM   460  C CA  . ARG A 1 60  ? 29.59770 -0.79387  -22.81585 1.000 28.00037  ? 60  ARG A CA  1 
ATOM   461  C C   . ARG A 1 60  ? 28.22553 -0.15856  -22.73885 1.000 24.78718  ? 60  ARG A C   1 
ATOM   462  O O   . ARG A 1 60  ? 27.69614 0.21133   -23.78245 1.000 33.06196  ? 60  ARG A O   1 
ATOM   463  C CB  . ARG A 1 60  ? 29.54301 -1.99625  -23.76196 1.000 23.76046  ? 60  ARG A CB  1 
ATOM   464  C CG  . ARG A 1 60  ? 30.89154 -2.64759  -23.95785 1.000 24.82335  ? 60  ARG A CG  1 
ATOM   465  C CD  . ARG A 1 60  ? 30.90969 -3.78772  -24.96842 1.000 25.60509  ? 60  ARG A CD  1 
ATOM   466  N NE  . ARG A 1 60  ? 32.10416 -4.60672  -24.78751 1.000 25.04039  ? 60  ARG A NE  1 
ATOM   467  C CZ  . ARG A 1 60  ? 33.07636 -4.68820  -25.69334 1.000 42.48145  ? 60  ARG A CZ  1 
ATOM   468  N NH1 . ARG A 1 60  ? 33.02245 -4.00765  -26.83282 1.000 34.94829  ? 60  ARG A NH1 1 
ATOM   469  N NH2 . ARG A 1 60  ? 34.15298 -5.42866  -25.43527 1.000 31.82721  ? 60  ARG A NH2 1 
ATOM   470  N N   . LYS A 1 61  ? 27.61586 -0.04694  -21.55752 1.000 27.96494  ? 61  LYS A N   1 
ATOM   471  C CA  . LYS A 1 61  ? 26.29492 0.54862   -21.41246 1.000 28.67998  ? 61  LYS A CA  1 
ATOM   472  C C   . LYS A 1 61  ? 26.38756 1.92407   -20.76493 1.000 32.30482  ? 61  LYS A C   1 
ATOM   473  O O   . LYS A 1 61  ? 27.31615 2.21570   -20.00644 1.000 28.95511  ? 61  LYS A O   1 
ATOM   474  C CB  . LYS A 1 61  ? 25.34689 -0.33080  -20.56385 1.000 32.45480  ? 61  LYS A CB  1 
ATOM   475  C CG  . LYS A 1 61  ? 25.15149 -1.76272  -21.07133 1.000 29.02619  ? 61  LYS A CG  1 
ATOM   476  C CD  . LYS A 1 61  ? 24.22948 -1.81252  -22.25308 1.000 39.11388  ? 61  LYS A CD  1 
ATOM   477  C CE  . LYS A 1 61  ? 23.55110 -3.15762  -22.39769 1.000 37.52449  ? 61  LYS A CE  1 
ATOM   478  N NZ  . LYS A 1 61  ? 24.51762 -4.22673  -22.79559 1.000 50.37325  ? 61  LYS A NZ  1 
ATOM   479  N N   . SER A 1 62  ? 25.38125 2.74391   -21.04617 1.000 32.60602  ? 62  SER A N   1 
ATOM   480  C CA  . SER A 1 62  ? 25.16158 4.05309   -20.44745 1.000 39.24631  ? 62  SER A CA  1 
ATOM   481  C C   . SER A 1 62  ? 23.91675 4.01693   -19.56246 1.000 33.49599  ? 62  SER A C   1 
ATOM   482  O O   . SER A 1 62  ? 23.06751 3.12509   -19.68491 1.000 37.50772  ? 62  SER A O   1 
ATOM   483  C CB  . SER A 1 62  ? 24.99497 5.13898   -21.53079 1.000 44.46781  ? 62  SER A CB  1 
ATOM   484  O OG  . SER A 1 62  ? 25.96805 5.04418   -22.57701 1.000 47.30095  ? 62  SER A OG  1 
ATOM   485  N N   . ASN A 1 63  ? 23.80867 5.00775   -18.66612 1.000 30.51240  ? 63  ASN A N   1 
ATOM   486  C CA  . ASN A 1 63  ? 22.60183 5.13557   -17.84457 1.000 30.19667  ? 63  ASN A CA  1 
ATOM   487  C C   . ASN A 1 63  ? 21.32309 5.10986   -18.69148 1.000 44.16938  ? 63  ASN A C   1 
ATOM   488  O O   . ASN A 1 63  ? 20.32836 4.47290   -18.31473 1.000 34.74570  ? 63  ASN A O   1 
ATOM   489  C CB  . ASN A 1 63  ? 22.64448 6.41922   -17.01507 1.000 27.13827  ? 63  ASN A CB  1 
ATOM   490  C CG  . ASN A 1 63  ? 23.59853 6.34536   -15.84004 1.000 41.29525  ? 63  ASN A CG  1 
ATOM   491  O OD1 . ASN A 1 63  ? 24.00533 5.26318   -15.39647 1.000 33.58807  ? 63  ASN A OD1 1 
ATOM   492  N ND2 . ASN A 1 63  ? 23.97250 7.51635   -15.32121 1.000 35.33351  ? 63  ASN A ND2 1 
ATOM   493  N N   . HIS A 1 64  ? 21.31983 5.80243   -19.83936 1.000 45.16091  ? 64  HIS A N   1 
ATOM   494  C CA  . HIS A 1 64  ? 20.12006 5.83625   -20.68170 1.000 40.00901  ? 64  HIS A CA  1 
ATOM   495  C C   . HIS A 1 64  ? 19.82297 4.48591   -21.32542 1.000 33.08649  ? 64  HIS A C   1 
ATOM   496  O O   . HIS A 1 64  ? 18.74958 4.31337   -21.91127 1.000 30.22768  ? 64  HIS A O   1 
ATOM   497  C CB  . HIS A 1 64  ? 20.24350 6.93906   -21.76062 1.000 32.10971  ? 64  HIS A CB  1 
ATOM   498  C CG  . HIS A 1 64  ? 21.20193 6.60769   -22.86805 1.000 30.73025  ? 64  HIS A CG  1 
ATOM   499  N ND1 . HIS A 1 64  ? 22.47594 7.13314   -22.93023 1.000 39.43002  ? 64  HIS A ND1 1 
ATOM   500  C CD2 . HIS A 1 64  ? 21.06959 5.81617   -23.96137 1.000 45.62693  ? 64  HIS A CD2 1 
ATOM   501  C CE1 . HIS A 1 64  ? 23.09664 6.65824   -23.99928 1.000 32.56502  ? 64  HIS A CE1 1 
ATOM   502  N NE2 . HIS A 1 64  ? 22.26347 5.86027   -24.64356 1.000 40.96169  ? 64  HIS A NE2 1 
ATOM   503  N N   . ASN A 1 65  ? 20.73425 3.51790   -21.23068 1.000 36.78294  ? 65  ASN A N   1 
ATOM   504  C CA  . ASN A 1 65  ? 20.40760 2.20248   -21.76108 1.000 31.01035  ? 65  ASN A CA  1 
ATOM   505  C C   . ASN A 1 65  ? 19.42667 1.42790   -20.87201 1.000 34.52514  ? 65  ASN A C   1 
ATOM   506  O O   . ASN A 1 65  ? 18.96617 0.36165   -21.29369 1.000 37.93750  ? 65  ASN A O   1 
ATOM   507  C CB  . ASN A 1 65  ? 21.67496 1.37937   -21.93361 1.000 26.74541  ? 65  ASN A CB  1 
ATOM   508  C CG  . ASN A 1 65  ? 22.50174 1.81217   -23.11406 1.000 35.58562  ? 65  ASN A CG  1 
ATOM   509  O OD1 . ASN A 1 65  ? 23.67438 2.12435   -22.95985 1.000 33.92204  ? 65  ASN A OD1 1 
ATOM   510  N ND2 . ASN A 1 65  ? 21.90366 1.82814   -24.29537 1.000 42.14177  ? 65  ASN A ND2 1 
ATOM   511  N N   . PHE A 1 66  ? 19.09874 1.92798   -19.66543 1.000 29.82595  ? 66  PHE A N   1 
ATOM   512  C CA  . PHE A 1 66  ? 18.24209 1.22253   -18.69163 1.000 32.60607  ? 66  PHE A CA  1 
ATOM   513  C C   . PHE A 1 66  ? 16.89835 1.93500   -18.53477 1.000 33.27538  ? 66  PHE A C   1 
ATOM   514  O O   . PHE A 1 66  ? 16.82511 3.02836   -17.96035 1.000 35.82944  ? 66  PHE A O   1 
ATOM   515  C CB  . PHE A 1 66  ? 18.91081 1.11330   -17.31461 1.000 24.70058  ? 66  PHE A CB  1 
ATOM   516  C CG  . PHE A 1 66  ? 20.19035 0.31800   -17.30880 1.000 29.83604  ? 66  PHE A CG  1 
ATOM   517  C CD1 . PHE A 1 66  ? 20.16692 -1.07063  -17.28589 1.000 23.12203  ? 66  PHE A CD1 1 
ATOM   518  C CD2 . PHE A 1 66  ? 21.41669 0.95693   -17.35918 1.000 19.08281  ? 66  PHE A CD2 1 
ATOM   519  C CE1 . PHE A 1 66  ? 21.35956 -1.80428  -17.30625 1.000 33.57682  ? 66  PHE A CE1 1 
ATOM   520  C CE2 . PHE A 1 66  ? 22.60285 0.22145   -17.37633 1.000 23.15982  ? 66  PHE A CE2 1 
ATOM   521  C CZ  . PHE A 1 66  ? 22.57043 -1.15608  -17.35291 1.000 31.68874  ? 66  PHE A CZ  1 
ATOM   522  N N   . LEU A 1 67  ? 15.82714 1.28037   -18.96673 1.000 23.87693  ? 67  LEU A N   1 
ATOM   523  C CA  . LEU A 1 67  ? 14.48653 1.82423   -18.83910 1.000 24.11472  ? 67  LEU A CA  1 
ATOM   524  C C   . LEU A 1 67  ? 13.85467 1.25180   -17.58366 1.000 27.57680  ? 67  LEU A C   1 
ATOM   525  O O   . LEU A 1 67  ? 13.63496 0.03696   -17.50197 1.000 33.98783  ? 67  LEU A O   1 
ATOM   526  C CB  . LEU A 1 67  ? 13.64004 1.46417   -20.05767 1.000 30.73433  ? 67  LEU A CB  1 
ATOM   527  C CG  . LEU A 1 67  ? 13.95318 1.94009   -21.48753 1.000 45.84475  ? 67  LEU A CG  1 
ATOM   528  C CD1 . LEU A 1 67  ? 15.39071 1.64192   -21.97474 1.000 44.53294  ? 67  LEU A CD1 1 
ATOM   529  C CD2 . LEU A 1 67  ? 12.91513 1.32453   -22.43781 1.000 55.18879  ? 67  LEU A CD2 1 
ATOM   530  N N   . VAL A 1 68  ? 13.56859 2.11059   -16.61247 1.000 29.36043  ? 68  VAL A N   1 
ATOM   531  C CA  . VAL A 1 68  ? 12.92788 1.71728   -15.36109 1.000 34.46402  ? 68  VAL A CA  1 
ATOM   532  C C   . VAL A 1 68  ? 11.52531 2.31178   -15.33401 1.000 33.62470  ? 68  VAL A C   1 
ATOM   533  O O   . VAL A 1 68  ? 11.35600 3.53664   -15.40664 1.000 32.91760  ? 68  VAL A O   1 
ATOM   534  C CB  . VAL A 1 68  ? 13.74034 2.17188   -14.13711 1.000 28.15440  ? 68  VAL A CB  1 
ATOM   535  C CG1 . VAL A 1 68  ? 13.03954 1.75622   -12.85448 1.000 27.67160  ? 68  VAL A CG1 1 
ATOM   536  C CG2 . VAL A 1 68  ? 15.15166 1.59374   -14.18806 1.000 26.68872  ? 68  VAL A CG2 1 
ATOM   537  N N   . GLN A 1 69  ? 10.51363 1.45481   -15.22031 1.000 26.84394  ? 69  GLN A N   1 
ATOM   538  C CA  . GLN A 1 69  ? 9.12639  1.91511   -15.13211 1.000 34.25354  ? 69  GLN A CA  1 
ATOM   539  C C   . GLN A 1 69  ? 8.47636  1.45990   -13.83183 1.000 32.39620  ? 69  GLN A C   1 
ATOM   540  O O   . GLN A 1 69  ? 8.42312  0.26184   -13.54004 1.000 30.05610  ? 69  GLN A O   1 
ATOM   541  C CB  . GLN A 1 69  ? 8.31506  1.44984   -16.34720 1.000 31.19254  ? 69  GLN A CB  1 
ATOM   542  C CG  . GLN A 1 69  ? 9.14068  1.48027   -17.61745 1.000 41.99293  ? 69  GLN A CG  1 
ATOM   543  C CD  . GLN A 1 69  ? 8.49347  0.75128   -18.76423 1.000 61.56275  ? 69  GLN A CD  1 
ATOM   544  O OE1 . GLN A 1 69  ? 9.18564  0.22243   -19.64428 1.000 47.53168  ? 69  GLN A OE1 1 
ATOM   545  N NE2 . GLN A 1 69  ? 7.15820  0.68631   -18.75299 1.000 66.66733  ? 69  GLN A NE2 1 
ATOM   546  N N   . ALA A 1 70  ? 7.98749  2.42904   -13.06612 1.000 23.24297  ? 70  ALA A N   1 
ATOM   547  C CA  . ALA A 1 70  ? 7.22834  2.23154   -11.84271 1.000 27.38817  ? 70  ALA A CA  1 
ATOM   548  C C   . ALA A 1 70  ? 5.77776  2.54245   -12.18587 1.000 42.24979  ? 70  ALA A C   1 
ATOM   549  O O   . ALA A 1 70  ? 5.39107  3.70953   -12.25806 1.000 33.65802  ? 70  ALA A O   1 
ATOM   550  C CB  . ALA A 1 70  ? 7.74672  3.13019   -10.72686 1.000 34.41654  ? 70  ALA A CB  1 
ATOM   551  N N   . GLY A 1 71  ? 4.98836  1.50317   -12.41191 1.000 49.85363  ? 71  GLY A N   1 
ATOM   552  C CA  . GLY A 1 71  ? 3.62538  1.70867   -12.86936 1.000 42.47556  ? 71  GLY A CA  1 
ATOM   553  C C   . GLY A 1 71  ? 3.66561  2.45418   -14.18437 1.000 50.39573  ? 71  GLY A C   1 
ATOM   554  O O   . GLY A 1 71  ? 4.30341  2.02153   -15.15639 1.000 50.55209  ? 71  GLY A O   1 
ATOM   555  N N   . ASN A 1 72  ? 3.01260  3.61464   -14.21240 1.000 54.38707  ? 72  ASN A N   1 
ATOM   556  C CA  . ASN A 1 72  ? 3.01132  4.45060   -15.40583 1.000 61.55869  ? 72  ASN A CA  1 
ATOM   557  C C   . ASN A 1 72  ? 3.84303  5.70351   -15.17434 1.000 56.97471  ? 72  ASN A C   1 
ATOM   558  O O   . ASN A 1 72  ? 3.37983  6.82435   -15.41165 1.000 62.64663  ? 72  ASN A O   1 
ATOM   559  C CB  . ASN A 1 72  ? 1.57925  4.81287   -15.80806 1.000 65.76669  ? 72  ASN A CB  1 
ATOM   560  C CG  . ASN A 1 72  ? 0.77344  3.59670   -16.24157 1.000 75.41373  ? 72  ASN A CG  1 
ATOM   561  O OD1 . ASN A 1 72  ? 1.28243  2.70869   -16.94201 1.000 63.95096  ? 72  ASN A OD1 1 
ATOM   562  N ND2 . ASN A 1 72  ? -0.48915 3.54858   -15.82606 1.000 76.91015  ? 72  ASN A ND2 1 
ATOM   563  N N   . VAL A 1 73  ? 5.06797  5.51868   -14.69043 1.000 48.48709  ? 73  VAL A N   1 
ATOM   564  C CA  . VAL A 1 73  ? 6.02970  6.60372   -14.55526 1.000 31.16893  ? 73  VAL A CA  1 
ATOM   565  C C   . VAL A 1 73  ? 7.39119  6.05044   -14.93591 1.000 50.28303  ? 73  VAL A C   1 
ATOM   566  O O   . VAL A 1 73  ? 7.82425  5.03076   -14.38139 1.000 38.99136  ? 73  VAL A O   1 
ATOM   567  C CB  . VAL A 1 73  ? 6.06877  7.19393   -13.13600 1.000 37.83131  ? 73  VAL A CB  1 
ATOM   568  C CG1 . VAL A 1 73  ? 7.36010  7.97324   -12.93343 1.000 40.48411  ? 73  VAL A CG1 1 
ATOM   569  C CG2 . VAL A 1 73  ? 4.86163  8.08387   -12.89498 1.000 44.67678  ? 73  VAL A CG2 1 
ATOM   570  N N   . GLN A 1 74  ? 8.04063  6.68384   -15.91361 1.000 53.95298  ? 74  GLN A N   1 
ATOM   571  C CA  . GLN A 1 74  ? 9.43233  6.38256   -16.19810 1.000 33.85085  ? 74  GLN A CA  1 
ATOM   572  C C   . GLN A 1 74  ? 10.29684 7.00092   -15.11084 1.000 47.72547  ? 74  GLN A C   1 
ATOM   573  O O   . GLN A 1 74  ? 10.11145 8.16665   -14.74292 1.000 38.37509  ? 74  GLN A O   1 
ATOM   574  C CB  . GLN A 1 74  ? 9.83098  6.89401   -17.58540 1.000 44.34164  ? 74  GLN A CB  1 
ATOM   575  C CG  . GLN A 1 74  ? 10.94907 6.08901   -18.26351 1.000 51.19946  ? 74  GLN A CG  1 
ATOM   576  C CD  . GLN A 1 74  ? 11.94349 6.95905   -19.04812 1.000 63.87054  ? 74  GLN A CD  1 
ATOM   577  O OE1 . GLN A 1 74  ? 12.18632 8.11905   -18.70107 1.000 68.64034  ? 74  GLN A OE1 1 
ATOM   578  N NE2 . GLN A 1 74  ? 12.54854 6.38082   -20.08762 1.000 56.22591  ? 74  GLN A NE2 1 
ATOM   579  N N   . LEU A 1 75  ? 11.19196 6.19160   -14.54700 1.000 42.78593  ? 75  LEU A N   1 
ATOM   580  C CA  . LEU A 1 75  ? 12.19257 6.66231   -13.60291 1.000 31.93189  ? 75  LEU A CA  1 
ATOM   581  C C   . LEU A 1 75  ? 13.49438 6.84709   -14.36667 1.000 30.27026  ? 75  LEU A C   1 
ATOM   582  O O   . LEU A 1 75  ? 13.86318 6.00964   -15.20450 1.000 48.75998  ? 75  LEU A O   1 
ATOM   583  C CB  . LEU A 1 75  ? 12.38937 5.67157   -12.45051 1.000 36.88200  ? 75  LEU A CB  1 
ATOM   584  C CG  . LEU A 1 75  ? 11.22768 5.42333   -11.47877 1.000 42.54820  ? 75  LEU A CG  1 
ATOM   585  C CD1 . LEU A 1 75  ? 11.60933 4.37539   -10.42478 1.000 38.09572  ? 75  LEU A CD1 1 
ATOM   586  C CD2 . LEU A 1 75  ? 10.74463 6.70932   -10.82183 1.000 37.56448  ? 75  LEU A CD2 1 
ATOM   587  N N   . ARG A 1 76  ? 14.18066 7.95526   -14.11706 1.000 36.79502  ? 76  ARG A N   1 
ATOM   588  C CA  . ARG A 1 76  ? 15.42412 8.19515   -14.83143 1.000 45.60203  ? 76  ARG A CA  1 
ATOM   589  C C   . ARG A 1 76  ? 16.58377 7.63119   -14.01854 1.000 24.92440  ? 76  ARG A C   1 
ATOM   590  O O   . ARG A 1 76  ? 16.71677 7.92818   -12.82444 1.000 30.96914  ? 76  ARG A O   1 
ATOM   591  C CB  . ARG A 1 76  ? 15.62167 9.68274   -15.13201 1.000 35.88395  ? 76  ARG A CB  1 
ATOM   592  C CG  . ARG A 1 76  ? 16.84211 9.99336   -16.02324 1.000 33.96955  ? 76  ARG A CG  1 
ATOM   593  C CD  . ARG A 1 76  ? 16.88503 11.48256  -16.33970 1.000 50.44530  ? 76  ARG A CD  1 
ATOM   594  N NE  . ARG A 1 76  ? 16.87197 12.26838  -15.11331 1.000 54.69790  ? 76  ARG A NE  1 
ATOM   595  C CZ  . ARG A 1 76  ? 17.89790 12.97797  -14.66532 1.000 64.42956  ? 76  ARG A CZ  1 
ATOM   596  N NH1 . ARG A 1 76  ? 19.01912 13.08139  -15.36019 1.000 65.59510  ? 76  ARG A NH1 1 
ATOM   597  N NH2 . ARG A 1 76  ? 17.79047 13.61171  -13.49766 1.000 54.55175  ? 76  ARG A NH2 1 
ATOM   598  N N   . VAL A 1 77  ? 17.39476 6.80362   -14.67729 1.000 29.67119  ? 77  VAL A N   1 
ATOM   599  C CA  . VAL A 1 77  ? 18.59586 6.21195   -14.09201 1.000 38.88095  ? 77  VAL A CA  1 
ATOM   600  C C   . VAL A 1 77  ? 19.72173 7.23148   -14.16931 1.000 37.67203  ? 77  VAL A C   1 
ATOM   601  O O   . VAL A 1 77  ? 20.11295 7.65221   -15.26556 1.000 26.53386  ? 77  VAL A O   1 
ATOM   602  C CB  . VAL A 1 77  ? 18.98201 4.91851   -14.82630 1.000 30.95737  ? 77  VAL A CB  1 
ATOM   603  C CG1 . VAL A 1 77  ? 20.38614 4.45739   -14.46234 1.000 23.79314  ? 77  VAL A CG1 1 
ATOM   604  C CG2 . VAL A 1 77  ? 17.93615 3.82966   -14.56531 1.000 33.78982  ? 77  VAL A CG2 1 
ATOM   605  N N   . ILE A 1 78  ? 20.26309 7.60317   -13.01008 1.000 42.41289  ? 78  ILE A N   1 
ATOM   606  C CA  . ILE A 1 78  ? 21.33683 8.58564   -12.91661 1.000 34.44545  ? 78  ILE A CA  1 
ATOM   607  C C   . ILE A 1 78  ? 22.66974 7.93855   -12.55692 1.000 36.81736  ? 78  ILE A C   1 
ATOM   608  O O   . ILE A 1 78  ? 23.65076 8.64140   -12.30231 1.000 29.95962  ? 78  ILE A O   1 
ATOM   609  C CB  . ILE A 1 78  ? 20.96418 9.69842   -11.92479 1.000 37.11457  ? 78  ILE A CB  1 
ATOM   610  C CG1 . ILE A 1 78  ? 20.57519 9.12929   -10.56267 1.000 26.59727  ? 78  ILE A CG1 1 
ATOM   611  C CG2 . ILE A 1 78  ? 19.75108 10.43517  -12.44177 1.000 30.31553  ? 78  ILE A CG2 1 
ATOM   612  C CD1 . ILE A 1 78  ? 20.82436 10.08578  -9.42179  1.000 34.40670  ? 78  ILE A CD1 1 
ATOM   613  N N   . GLY A 1 79  ? 22.73455 6.61490   -12.54294 1.000 33.65812  ? 79  GLY A N   1 
ATOM   614  C CA  . GLY A 1 79  ? 23.96193 5.92173   -12.18937 1.000 25.61594  ? 79  GLY A CA  1 
ATOM   615  C C   . GLY A 1 79  ? 23.69657 4.43254   -12.12967 1.000 29.51763  ? 79  GLY A C   1 
ATOM   616  O O   . GLY A 1 79  ? 22.54785 3.98884   -12.00828 1.000 32.81581  ? 79  GLY A O   1 
ATOM   617  N N   . HIS A 1 80  ? 24.78078 3.66831   -12.20938 1.000 25.54192  ? 80  HIS A N   1 
ATOM   618  C CA  . HIS A 1 80  ? 24.61891 2.22147   -12.17841 1.000 26.96463  ? 80  HIS A CA  1 
ATOM   619  C C   . HIS A 1 80  ? 25.91138 1.58753   -11.68346 1.000 39.85698  ? 80  HIS A C   1 
ATOM   620  O O   . HIS A 1 80  ? 26.99435 2.13063   -11.88394 1.000 25.20762  ? 80  HIS A O   1 
ATOM   621  C CB  . HIS A 1 80  ? 24.26417 1.66504   -13.55700 1.000 26.61826  ? 80  HIS A CB  1 
ATOM   622  C CG  . HIS A 1 80  ? 25.27955 1.96635   -14.61391 1.000 31.64326  ? 80  HIS A CG  1 
ATOM   623  N ND1 . HIS A 1 80  ? 25.25519 3.12062   -15.36689 1.000 36.30706  ? 80  HIS A ND1 1 
ATOM   624  C CD2 . HIS A 1 80  ? 26.35254 1.25614   -15.04437 1.000 39.27262  ? 80  HIS A CD2 1 
ATOM   625  C CE1 . HIS A 1 80  ? 26.27899 3.11438   -16.20948 1.000 31.48272  ? 80  HIS A CE1 1 
ATOM   626  N NE2 . HIS A 1 80  ? 26.94974 1.99011   -16.04218 1.000 35.69546  ? 80  HIS A NE2 1 
ATOM   627  N N   . SER A 1 81  ? 25.78914 0.42855   -11.04666 1.000 22.12782  ? 81  SER A N   1 
ATOM   628  C CA  . SER A 1 81  ? 26.96114 -0.36790  -10.71509 1.000 23.66316  ? 81  SER A CA  1 
ATOM   629  C C   . SER A 1 81  ? 26.54287 -1.82248  -10.62572 1.000 23.65354  ? 81  SER A C   1 
ATOM   630  O O   . SER A 1 81  ? 25.36040 -2.14342  -10.60245 1.000 22.47256  ? 81  SER A O   1 
ATOM   631  C CB  . SER A 1 81  ? 27.56950 0.04483   -9.38557  1.000 22.71608  ? 81  SER A CB  1 
ATOM   632  O OG  . SER A 1 81  ? 26.56436 -0.02700  -8.40065  1.000 27.74966  ? 81  SER A OG  1 
ATOM   633  N N   . MET A 1 82  ? 27.53721 -2.68832  -10.58512 1.000 20.81343  ? 82  MET A N   1 
ATOM   634  C CA  . MET A 1 82  ? 27.40400 -4.11568  -10.32328 1.000 18.19193  ? 82  MET A CA  1 
ATOM   635  C C   . MET A 1 82  ? 27.89611 -4.45437  -8.92927  1.000 18.48444  ? 82  MET A C   1 
ATOM   636  O O   . MET A 1 82  ? 29.01331 -4.08470  -8.57541  1.000 22.41274  ? 82  MET A O   1 
ATOM   637  C CB  . MET A 1 82  ? 28.24534 -4.94795  -11.27904 1.000 29.69020  ? 82  MET A CB  1 
ATOM   638  C CG  . MET A 1 82  ? 27.64760 -6.23340  -11.63759 1.000 25.84365  ? 82  MET A CG  1 
ATOM   639  S SD  . MET A 1 82  ? 28.22396 -6.99071  -13.10848 1.000 26.12092  ? 82  MET A SD  1 
ATOM   640  C CE  . MET A 1 82  ? 29.97586 -6.51666  -13.15747 1.000 27.55591  ? 82  MET A CE  1 
ATOM   641  N N   . GLN A 1 83  ? 27.09104 -5.20354  -8.16752  1.000 18.71480  ? 83  GLN A N   1 
ATOM   642  C CA  . GLN A 1 83  ? 27.54008 -5.82680  -6.92322  1.000 22.68618  ? 83  GLN A CA  1 
ATOM   643  C C   . GLN A 1 83  ? 27.26932 -7.31727  -7.06058  1.000 18.85905  ? 83  GLN A C   1 
ATOM   644  O O   . GLN A 1 83  ? 26.10609 -7.73916  -7.03582  1.000 15.76077  ? 83  GLN A O   1 
ATOM   645  C CB  . GLN A 1 83  ? 26.82974 -5.25950  -5.70420  1.000 19.79863  ? 83  GLN A CB  1 
ATOM   646  C CG  . GLN A 1 83  ? 27.23130 -5.93200  -4.38682  1.000 16.05103  ? 83  GLN A CG  1 
ATOM   647  C CD  . GLN A 1 83  ? 26.49529 -5.40002  -3.18929  1.000 18.37362  ? 83  GLN A CD  1 
ATOM   648  O OE1 . GLN A 1 83  ? 25.51102 -4.67102  -3.31379  1.000 20.06504  ? 83  GLN A OE1 1 
ATOM   649  N NE2 . GLN A 1 83  ? 26.93678 -5.78914  -2.01818  1.000 20.17615  ? 83  GLN A NE2 1 
ATOM   650  N N   . ASN A 1 84  ? 28.33216 -8.12610  -7.22848  1.000 15.18563  ? 84  ASN A N   1 
ATOM   651  C CA  . ASN A 1 84  ? 28.16471 -9.57374  -7.42083  1.000 13.99615  ? 84  ASN A CA  1 
ATOM   652  C C   . ASN A 1 84  ? 27.24929 -9.81719  -8.61450  1.000 18.37669  ? 84  ASN A C   1 
ATOM   653  O O   . ASN A 1 84  ? 27.53634 -9.30262  -9.71054  1.000 19.53072  ? 84  ASN A O   1 
ATOM   654  C CB  . ASN A 1 84  ? 27.67364 -10.16828 -6.11026  1.000 14.52052  ? 84  ASN A CB  1 
ATOM   655  C CG  . ASN A 1 84  ? 28.59746 -9.85382  -4.99339  1.000 13.54661  ? 84  ASN A CG  1 
ATOM   656  O OD1 . ASN A 1 84  ? 29.78500 -10.06521 -5.13740  1.000 16.62056  ? 84  ASN A OD1 1 
ATOM   657  N ND2 . ASN A 1 84  ? 28.07019 -9.35491  -3.87670  1.000 13.05490  ? 84  ASN A ND2 1 
ATOM   658  N N   . CYS A 1 85  ? 26.14971 -10.55652 -8.46923  1.000 10.65284  ? 85  CYS A N   1 
ATOM   659  C CA  . CYS A 1 85  ? 25.29001 -10.81622 -9.60977  1.000 14.12504  ? 85  CYS A CA  1 
ATOM   660  C C   . CYS A 1 85  ? 24.07395 -9.89145  -9.66271  1.000 11.65073  ? 85  CYS A C   1 
ATOM   661  O O   . CYS A 1 85  ? 23.11758 -10.18248 -10.38030 1.000 14.89398  ? 85  CYS A O   1 
ATOM   662  C CB  . CYS A 1 85  ? 24.88792 -12.29352 -9.63696  1.000 13.77463  ? 85  CYS A CB  1 
ATOM   663  S SG  . CYS A 1 85  ? 26.30005 -13.39587 -9.79374  1.000 15.55342  ? 85  CYS A SG  1 
ATOM   664  N N   . VAL A 1 86  ? 24.08298 -8.77469  -8.95183  1.000 12.29435  ? 86  VAL A N   1 
ATOM   665  C CA  . VAL A 1 86  ? 22.95614 -7.84239  -9.07577  1.000 15.17369  ? 86  VAL A CA  1 
ATOM   666  C C   . VAL A 1 86  ? 23.45133 -6.51346  -9.61567  1.000 22.63292  ? 86  VAL A C   1 
ATOM   667  O O   . VAL A 1 86  ? 24.58770 -6.10667  -9.37258  1.000 23.44821  ? 86  VAL A O   1 
ATOM   668  C CB  . VAL A 1 86  ? 22.16797 -7.61268  -7.76518  1.000 19.22940  ? 86  VAL A CB  1 
ATOM   669  C CG1 . VAL A 1 86  ? 21.38523 -8.91411  -7.37897  1.000 19.91364  ? 86  VAL A CG1 1 
ATOM   670  C CG2 . VAL A 1 86  ? 23.04141 -7.06625  -6.65118  1.000 23.20664  ? 86  VAL A CG2 1 
ATOM   671  N N   . LEU A 1 87  ? 22.57163 -5.83820  -10.34946 1.000 18.64428  ? 87  LEU A N   1 
ATOM   672  C CA  . LEU A 1 87  ? 22.78435 -4.47036  -10.80280 1.000 19.42306  ? 87  LEU A CA  1 
ATOM   673  C C   . LEU A 1 87  ? 22.11278 -3.52285  -9.82697  1.000 18.07267  ? 87  LEU A C   1 
ATOM   674  O O   . LEU A 1 87  ? 21.00797 -3.80175  -9.34455  1.000 18.98104  ? 87  LEU A O   1 
ATOM   675  C CB  . LEU A 1 87  ? 22.16882 -4.26709  -12.18478 1.000 25.97837  ? 87  LEU A CB  1 
ATOM   676  C CG  . LEU A 1 87  ? 22.85381 -4.67953  -13.47198 1.000 37.30886  ? 87  LEU A CG  1 
ATOM   677  C CD1 . LEU A 1 87  ? 22.15906 -3.88424  -14.59089 1.000 28.74534  ? 87  LEU A CD1 1 
ATOM   678  C CD2 . LEU A 1 87  ? 24.39690 -4.47095  -13.45162 1.000 34.75842  ? 87  LEU A CD2 1 
ATOM   679  N N   . LYS A 1 88  ? 22.75391 -2.38687  -9.54294  1.000 19.49494  ? 88  LYS A N   1 
ATOM   680  C CA  . LYS A 1 88  ? 22.11534 -1.33664  -8.74953  1.000 18.98909  ? 88  LYS A CA  1 
ATOM   681  C C   . LYS A 1 88  ? 21.99899 -0.08441  -9.60497  1.000 31.79758  ? 88  LYS A C   1 
ATOM   682  O O   . LYS A 1 88  ? 23.00450 0.53336   -9.95705  1.000 24.45484  ? 88  LYS A O   1 
ATOM   683  C CB  . LYS A 1 88  ? 22.86500 -1.06793  -7.44239  1.000 17.45579  ? 88  LYS A CB  1 
ATOM   684  C CG  . LYS A 1 88  ? 23.05166 -2.32421  -6.60010  1.000 19.24936  ? 88  LYS A CG  1 
ATOM   685  C CD  . LYS A 1 88  ? 23.66175 -2.04246  -5.23690  1.000 19.41644  ? 88  LYS A CD  1 
ATOM   686  C CE  . LYS A 1 88  ? 25.14510 -1.85665  -5.31732  1.000 25.62516  ? 88  LYS A CE  1 
ATOM   687  N NZ  . LYS A 1 88  ? 25.64497 -1.97018  -3.92319  1.000 24.56271  ? 88  LYS A NZ  1 
ATOM   688  N N   . LEU A 1 89  ? 20.77941 0.28083   -9.93907  1.000 21.24086  ? 89  LEU A N   1 
ATOM   689  C CA  . LEU A 1 89  ? 20.50252 1.44748   -10.78356 1.000 18.86965  ? 89  LEU A CA  1 
ATOM   690  C C   . LEU A 1 89  ? 20.11022 2.57337   -9.85725  1.000 24.14159  ? 89  LEU A C   1 
ATOM   691  O O   . LEU A 1 89  ? 19.08029 2.48934   -9.19015  1.000 22.67385  ? 89  LEU A O   1 
ATOM   692  C CB  . LEU A 1 89  ? 19.38222 1.15216   -11.78402 1.000 17.93688  ? 89  LEU A CB  1 
ATOM   693  C CG  . LEU A 1 89  ? 19.61243 -0.06555  -12.66839 1.000 19.16595  ? 89  LEU A CG  1 
ATOM   694  C CD1 . LEU A 1 89  ? 18.42379 -0.26772  -13.62302 1.000 20.49657  ? 89  LEU A CD1 1 
ATOM   695  C CD2 . LEU A 1 89  ? 20.94612 0.00240   -13.43240 1.000 23.08755  ? 89  LEU A CD2 1 
ATOM   696  N N   . LYS A 1 90  ? 20.93307 3.61895   -9.78627  1.000 18.80791  ? 90  LYS A N   1 
ATOM   697  C CA  . LYS A 1 90  ? 20.56181 4.76094   -8.97367  1.000 18.70023  ? 90  LYS A CA  1 
ATOM   698  C C   . LYS A 1 90  ? 19.59241 5.61114   -9.79474  1.000 25.66572  ? 90  LYS A C   1 
ATOM   699  O O   . LYS A 1 90  ? 19.79780 5.80417   -10.99667 1.000 27.33294  ? 90  LYS A O   1 
ATOM   700  C CB  . LYS A 1 90  ? 21.80457 5.55291   -8.53161  1.000 25.25175  ? 90  LYS A CB  1 
ATOM   701  C CG  . LYS A 1 90  ? 21.47617 6.70930   -7.59150  1.000 25.80479  ? 90  LYS A CG  1 
ATOM   702  C CD  . LYS A 1 90  ? 22.70394 7.10638   -6.76937  1.000 45.29651  ? 90  LYS A CD  1 
ATOM   703  C CE  . LYS A 1 90  ? 22.46501 8.37422   -5.95787  1.000 49.89545  ? 90  LYS A CE  1 
ATOM   704  N NZ  . LYS A 1 90  ? 22.98960 9.60856   -6.63330  1.000 49.11947  ? 90  LYS A NZ  1 
ATOM   705  N N   . VAL A 1 91  ? 18.49443 6.04514   -9.16648  1.000 25.86659  ? 91  VAL A N   1 
ATOM   706  C CA  . VAL A 1 91  ? 17.43873 6.75721   -9.87137  1.000 28.69437  ? 91  VAL A CA  1 
ATOM   707  C C   . VAL A 1 91  ? 17.24053 8.10465   -9.19678  1.000 26.67606  ? 91  VAL A C   1 
ATOM   708  O O   . VAL A 1 91  ? 17.61936 8.31573   -8.03964  1.000 31.37314  ? 91  VAL A O   1 
ATOM   709  C CB  . VAL A 1 91  ? 16.11225 5.95839   -9.93579  1.000 32.22354  ? 91  VAL A CB  1 
ATOM   710  C CG1 . VAL A 1 91  ? 16.22998 4.82674   -10.94963 1.000 33.08292  ? 91  VAL A CG1 1 
ATOM   711  C CG2 . VAL A 1 91  ? 15.69549 5.43484   -8.56248  1.000 30.58672  ? 91  VAL A CG2 1 
ATOM   712  N N   . ASP A 1 92  ? 16.64448 9.03720   -9.95405  1.000 40.20575  ? 92  ASP A N   1 
ATOM   713  C CA  . ASP A 1 92  ? 16.48668 10.41166  -9.48479  1.000 38.61058  ? 92  ASP A CA  1 
ATOM   714  C C   . ASP A 1 92  ? 15.46001 10.55119  -8.36968  1.000 43.48810  ? 92  ASP A C   1 
ATOM   715  O O   . ASP A 1 92  ? 15.46323 11.56800  -7.66390  1.000 38.27990  ? 92  ASP A O   1 
ATOM   716  C CB  . ASP A 1 92  ? 16.12103 11.31326  -10.66811 1.000 42.38637  ? 92  ASP A CB  1 
ATOM   717  C CG  . ASP A 1 92  ? 14.78317 10.93294  -11.31535 1.000 53.67662  ? 92  ASP A CG  1 
ATOM   718  O OD1 . ASP A 1 92  ? 14.49216 11.46593  -12.40680 1.000 65.64475  ? 92  ASP A OD1 1 
ATOM   719  O OD2 . ASP A 1 92  ? 14.03603 10.08633  -10.77301 1.000 58.03672  ? 92  ASP A OD2 1 
ATOM   720  N N   . THR A 1 93  ? 14.58346 9.56182   -8.19447  1.000 32.06417  ? 93  THR A N   1 
ATOM   721  C CA  . THR A 1 93  ? 13.49542 9.64105   -7.23068  1.000 33.76587  ? 93  THR A CA  1 
ATOM   722  C C   . THR A 1 93  ? 13.65245 8.55234   -6.17818  1.000 35.25400  ? 93  THR A C   1 
ATOM   723  O O   . THR A 1 93  ? 13.87271 7.38756   -6.52088  1.000 30.03244  ? 93  THR A O   1 
ATOM   724  C CB  . THR A 1 93  ? 12.13266 9.47470   -7.91102  1.000 36.67193  ? 93  THR A CB  1 
ATOM   725  O OG1 . THR A 1 93  ? 12.12497 10.15325  -9.17415  1.000 38.59670  ? 93  THR A OG1 1 
ATOM   726  C CG2 . THR A 1 93  ? 11.08248 10.07954  -7.03622  1.000 29.42596  ? 93  THR A CG2 1 
ATOM   727  N N   . ALA A 1 94  ? 13.53566 8.92589   -4.91085  1.000 26.40071  ? 94  ALA A N   1 
ATOM   728  C CA  . ALA A 1 94  ? 13.40183 7.91714   -3.87211  1.000 25.05963  ? 94  ALA A CA  1 
ATOM   729  C C   . ALA A 1 94  ? 11.99549 7.33348   -3.91757  1.000 30.93296  ? 94  ALA A C   1 
ATOM   730  O O   . ALA A 1 94  ? 11.03522 8.00329   -4.29816  1.000 28.49775  ? 94  ALA A O   1 
ATOM   731  C CB  . ALA A 1 94  ? 13.66904 8.50186   -2.49875  1.000 22.11787  ? 94  ALA A CB  1 
ATOM   732  N N   . ASN A 1 95  ? 11.88485 6.05988   -3.57693  1.000 21.41062  ? 95  ASN A N   1 
ATOM   733  C CA  . ASN A 1 95  ? 10.57634 5.42115   -3.52532  1.000 23.35531  ? 95  ASN A CA  1 
ATOM   734  C C   . ASN A 1 95  ? 9.83010  5.87521   -2.27404  1.000 20.04125  ? 95  ASN A C   1 
ATOM   735  O O   . ASN A 1 95  ? 10.27954 5.58603   -1.16190  1.000 22.25288  ? 95  ASN A O   1 
ATOM   736  C CB  . ASN A 1 95  ? 10.73993 3.90192   -3.53703  1.000 20.73651  ? 95  ASN A CB  1 
ATOM   737  C CG  . ASN A 1 95  ? 9.40200  3.17264   -3.64509  1.000 24.99719  ? 95  ASN A CG  1 
ATOM   738  O OD1 . ASN A 1 95  ? 8.32607  3.78672   -3.62414  1.000 22.21034  ? 95  ASN A OD1 1 
ATOM   739  N ND2 . ASN A 1 95  ? 9.47340  1.86594   -3.81612  1.000 23.21144  ? 95  ASN A ND2 1 
ATOM   740  N N   . PRO A 1 96  ? 8.69727  6.57668   -2.40619  1.000 23.03602  ? 96  PRO A N   1 
ATOM   741  C CA  . PRO A 1 96  ? 8.00458  7.04935   -1.20230  1.000 28.18150  ? 96  PRO A CA  1 
ATOM   742  C C   . PRO A 1 96  ? 7.34819  5.92394   -0.43090  1.000 28.94633  ? 96  PRO A C   1 
ATOM   743  O O   . PRO A 1 96  ? 7.01942  6.10020   0.74763   1.000 27.01784  ? 96  PRO A O   1 
ATOM   744  C CB  . PRO A 1 96  ? 6.97631  8.04895   -1.75787  1.000 22.83452  ? 96  PRO A CB  1 
ATOM   745  C CG  . PRO A 1 96  ? 6.73772  7.60498   -3.13753  1.000 20.67352  ? 96  PRO A CG  1 
ATOM   746  C CD  . PRO A 1 96  ? 8.01591  6.97987   -3.64295  1.000 27.28456  ? 96  PRO A CD  1 
ATOM   747  N N   . LYS A 1 97  ? 7.19352  4.75998   -1.04841  1.000 30.96161  ? 97  LYS A N   1 
ATOM   748  C CA  . LYS A 1 97  ? 6.67454  3.59499   -0.36256  1.000 25.38134  ? 97  LYS A CA  1 
ATOM   749  C C   . LYS A 1 97  ? 7.75308  2.67297   0.18267   1.000 24.15408  ? 97  LYS A C   1 
ATOM   750  O O   . LYS A 1 97  ? 7.43167  1.53792   0.54398   1.000 24.13870  ? 97  LYS A O   1 
ATOM   751  C CB  . LYS A 1 97  ? 5.74963  2.81118   -1.28276  1.000 20.16634  ? 97  LYS A CB  1 
ATOM   752  C CG  . LYS A 1 97  ? 4.66258  3.68238   -1.93287  1.000 34.59576  ? 97  LYS A CG  1 
ATOM   753  C CD  . LYS A 1 97  ? 3.75395  2.81891   -2.77518  1.000 38.83169  ? 97  LYS A CD  1 
ATOM   754  C CE  . LYS A 1 97  ? 2.81473  3.63219   -3.62485  1.000 40.63707  ? 97  LYS A CE  1 
ATOM   755  N NZ  . LYS A 1 97  ? 1.54445  2.86816   -3.74965  1.000 40.97877  ? 97  LYS A NZ  1 
ATOM   756  N N   . THR A 1 98  ? 9.00069  3.11635   0.26321   1.000 27.63199  ? 98  THR A N   1 
ATOM   757  C CA  . THR A 1 98  ? 10.04580 2.23926   0.78618   1.000 23.49271  ? 98  THR A CA  1 
ATOM   758  C C   . THR A 1 98  ? 9.66528  1.82617   2.20829   1.000 18.98271  ? 98  THR A C   1 
ATOM   759  O O   . THR A 1 98  ? 9.50650  2.70601   3.06749   1.000 23.62049  ? 98  THR A O   1 
ATOM   760  C CB  . THR A 1 98  ? 11.41403 2.95602   0.80226   1.000 21.20029  ? 98  THR A CB  1 
ATOM   761  O OG1 . THR A 1 98  ? 11.74417 3.38744   -0.51300  1.000 26.55242  ? 98  THR A OG1 1 
ATOM   762  C CG2 . THR A 1 98  ? 12.50121 1.95957   1.20230   1.000 21.26774  ? 98  THR A CG2 1 
ATOM   763  N N   . PRO A 1 99  ? 9.47489  0.51985   2.50026   1.000 16.47688  ? 99  PRO A N   1 
ATOM   764  C CA  . PRO A 1 99  ? 9.29887  0.09283   3.88949   1.000 16.67054  ? 99  PRO A CA  1 
ATOM   765  C C   . PRO A 1 99  ? 10.62130 0.11865   4.63555   1.000 22.16647  ? 99  PRO A C   1 
ATOM   766  O O   . PRO A 1 99  ? 11.70648 0.22338   4.05617   1.000 21.70232  ? 99  PRO A O   1 
ATOM   767  C CB  . PRO A 1 99  ? 8.78075  -1.34927  3.75746   1.000 18.57114  ? 99  PRO A CB  1 
ATOM   768  C CG  . PRO A 1 99  ? 9.53227  -1.83777  2.57371   1.000 16.12263  ? 99  PRO A CG  1 
ATOM   769  C CD  . PRO A 1 99  ? 9.67852  -0.63987  1.62409   1.000 20.13171  ? 99  PRO A CD  1 
ATOM   770  N N   . LYS A 1 100 ? 10.50520 -0.00587  5.94856   1.000 20.17308  ? 100 LYS A N   1 
ATOM   771  C CA  . LYS A 1 100 ? 11.63577 -0.40534  6.76655   1.000 18.11377  ? 100 LYS A CA  1 
ATOM   772  C C   . LYS A 1 100 ? 12.11521 -1.77180  6.29476   1.000 26.50648  ? 100 LYS A C   1 
ATOM   773  O O   . LYS A 1 100 ? 11.31216 -2.69578  6.13912   1.000 20.14917  ? 100 LYS A O   1 
ATOM   774  C CB  . LYS A 1 100 ? 11.22026 -0.47020  8.23111   1.000 20.20534  ? 100 LYS A CB  1 
ATOM   775  C CG  . LYS A 1 100 ? 12.36545 -0.47334  9.21900   1.000 31.65812  ? 100 LYS A CG  1 
ATOM   776  C CD  . LYS A 1 100 ? 11.90975 -0.01278  10.61403  1.000 44.33425  ? 100 LYS A CD  1 
ATOM   777  C CE  . LYS A 1 100 ? 12.30365 -1.03209  11.69839  1.000 56.51098  ? 100 LYS A CE  1 
ATOM   778  N NZ  . LYS A 1 100 ? 12.72553 -0.41418  13.00057  1.000 40.98935  ? 100 LYS A NZ  1 
ATOM   779  N N   . TYR A 1 101 ? 13.41558 -1.91225  6.04675   1.000 20.29047  ? 101 TYR A N   1 
ATOM   780  C CA  . TYR A 1 101 ? 13.84962 -3.18158  5.46321   1.000 15.07586  ? 101 TYR A CA  1 
ATOM   781  C C   . TYR A 1 101 ? 15.28240 -3.50098  5.83804   1.000 19.01252  ? 101 TYR A C   1 
ATOM   782  O O   . TYR A 1 101 ? 16.04831 -2.62852  6.23103   1.000 18.29504  ? 101 TYR A O   1 
ATOM   783  C CB  . TYR A 1 101 ? 13.71391 -3.16738  3.93235   1.000 14.34432  ? 101 TYR A CB  1 
ATOM   784  C CG  . TYR A 1 101 ? 14.78355 -2.34050  3.25878   1.000 23.10900  ? 101 TYR A CG  1 
ATOM   785  C CD1 . TYR A 1 101 ? 14.63068 -0.96315  3.11792   1.000 22.72237  ? 101 TYR A CD1 1 
ATOM   786  C CD2 . TYR A 1 101 ? 15.94183 -2.93037  2.78222   1.000 20.07575  ? 101 TYR A CD2 1 
ATOM   787  C CE1 . TYR A 1 101 ? 15.60418 -0.17198  2.50348   1.000 24.10889  ? 101 TYR A CE1 1 
ATOM   788  C CE2 . TYR A 1 101 ? 16.94431 -2.13466  2.17848   1.000 21.29302  ? 101 TYR A CE2 1 
ATOM   789  C CZ  . TYR A 1 101 ? 16.75010 -0.76011  2.04222   1.000 25.09623  ? 101 TYR A CZ  1 
ATOM   790  O OH  . TYR A 1 101 ? 17.71077 0.03008   1.43266   1.000 34.41169  ? 101 TYR A OH  1 
ATOM   791  N N   . LYS A 1 102 ? 15.64311 -4.77166  5.66045   1.000 16.97289  ? 102 LYS A N   1 
ATOM   792  C CA  . LYS A 1 102 ? 17.04054 -5.17280  5.70305   1.000 15.65505  ? 102 LYS A CA  1 
ATOM   793  C C   . LYS A 1 102 ? 17.21851 -6.23651  4.63300   1.000 17.42637  ? 102 LYS A C   1 
ATOM   794  O O   . LYS A 1 102 ? 16.24001 -6.79425  4.11740   1.000 14.85867  ? 102 LYS A O   1 
ATOM   795  C CB  . LYS A 1 102 ? 17.46834 -5.75885  7.06378   1.000 18.69398  ? 102 LYS A CB  1 
ATOM   796  C CG  . LYS A 1 102 ? 16.38330 -6.39725  7.84809   1.000 30.82113  ? 102 LYS A CG  1 
ATOM   797  C CD  . LYS A 1 102 ? 16.82686 -6.93495  9.24346   1.000 37.87028  ? 102 LYS A CD  1 
ATOM   798  C CE  . LYS A 1 102 ? 16.64065 -5.90104  10.35503  1.000 48.52174  ? 102 LYS A CE  1 
ATOM   799  N NZ  . LYS A 1 102 ? 17.12239 -6.38261  11.68509  1.000 39.71964  ? 102 LYS A NZ  1 
ATOM   800  N N   . PHE A 1 103 ? 18.47680 -6.47867  4.28350   1.000 13.58180  ? 103 PHE A N   1 
ATOM   801  C CA  . PHE A 1 103 ? 18.88210 -7.57487  3.41748   1.000 15.73218  ? 103 PHE A CA  1 
ATOM   802  C C   . PHE A 1 103 ? 19.48350 -8.66441  4.30267   1.000 10.78858  ? 103 PHE A C   1 
ATOM   803  O O   . PHE A 1 103 ? 20.34413 -8.37545  5.14359   1.000 13.82237  ? 103 PHE A O   1 
ATOM   804  C CB  . PHE A 1 103 ? 19.91532 -7.12064  2.38246   1.000 12.69655  ? 103 PHE A CB  1 
ATOM   805  C CG  . PHE A 1 103 ? 19.38573 -6.20676  1.30470   1.000 14.25004  ? 103 PHE A CG  1 
ATOM   806  C CD1 . PHE A 1 103 ? 18.01665 -6.01009  1.12451   1.000 15.56509  ? 103 PHE A CD1 1 
ATOM   807  C CD2 . PHE A 1 103 ? 20.27166 -5.54518  0.47104   1.000 15.45432  ? 103 PHE A CD2 1 
ATOM   808  C CE1 . PHE A 1 103 ? 17.54254 -5.17735  0.13225   1.000 13.93259  ? 103 PHE A CE1 1 
ATOM   809  C CE2 . PHE A 1 103 ? 19.80765 -4.69831  -0.51713  1.000 14.93639  ? 103 PHE A CE2 1 
ATOM   810  C CZ  . PHE A 1 103 ? 18.43785 -4.53240  -0.70116  1.000 16.62273  ? 103 PHE A CZ  1 
ATOM   811  N N   . VAL A 1 104 ? 19.02339 -9.90864  4.14644   1.000 9.69496   ? 104 VAL A N   1 
ATOM   812  C CA  . VAL A 1 104 ? 19.57110 -11.02961 4.90200   1.000 11.88305  ? 104 VAL A CA  1 
ATOM   813  C C   . VAL A 1 104 ? 19.85274 -12.19317 3.97488   1.000 12.14108  ? 104 VAL A C   1 
ATOM   814  O O   . VAL A 1 104 ? 19.07536 -12.49294 3.05931   1.000 12.19201  ? 104 VAL A O   1 
ATOM   815  C CB  . VAL A 1 104 ? 18.64339 -11.48342 6.04222   1.000 14.80161  ? 104 VAL A CB  1 
ATOM   816  C CG1 . VAL A 1 104 ? 18.27342 -10.27069 6.87685   1.000 19.41190  ? 104 VAL A CG1 1 
ATOM   817  C CG2 . VAL A 1 104 ? 17.41317 -12.00030 5.47886   1.000 17.67609  ? 104 VAL A CG2 1 
ATOM   818  N N   . ARG A 1 105 ? 20.93503 -12.89125 4.25766   1.000 10.36426  ? 105 ARG A N   1 
ATOM   819  C CA  . ARG A 1 105 ? 21.23345 -14.12565 3.55981   1.000 10.30500  ? 105 ARG A CA  1 
ATOM   820  C C   . ARG A 1 105 ? 20.83190 -15.29643 4.44961   1.000 9.73399   ? 105 ARG A C   1 
ATOM   821  O O   . ARG A 1 105 ? 21.41775 -15.49079 5.50864   1.000 10.92116  ? 105 ARG A O   1 
ATOM   822  C CB  . ARG A 1 105 ? 22.71947 -14.15130 3.18198   1.000 9.17922   ? 105 ARG A CB  1 
ATOM   823  C CG  . ARG A 1 105 ? 23.16441 -15.39283 2.38413   1.000 10.64343  ? 105 ARG A CG  1 
ATOM   824  C CD  . ARG A 1 105 ? 24.64916 -15.27349 1.93217   1.000 9.99120   ? 105 ARG A CD  1 
ATOM   825  N NE  . ARG A 1 105 ? 25.01673 -16.49819 1.25398   1.000 8.02515   ? 105 ARG A NE  1 
ATOM   826  C CZ  . ARG A 1 105 ? 24.74483 -16.73363 -0.02722  1.000 10.24100  ? 105 ARG A CZ  1 
ATOM   827  N NH1 . ARG A 1 105 ? 24.10265 -15.83764 -0.77299  1.000 11.10559  ? 105 ARG A NH1 1 
ATOM   828  N NH2 . ARG A 1 105 ? 25.07738 -17.91180 -0.55562  1.000 9.08128   ? 105 ARG A NH2 1 
ATOM   829  N N   . ILE A 1 106 ? 19.86963 -16.10217 4.00377   1.000 10.37709  ? 106 ILE A N   1 
ATOM   830  C CA  . ILE A 1 106 ? 19.31566 -17.13421 4.86642   1.000 10.62293  ? 106 ILE A CA  1 
ATOM   831  C C   . ILE A 1 106 ? 20.09278 -18.43194 4.72351   1.000 12.05835  ? 106 ILE A C   1 
ATOM   832  O O   . ILE A 1 106 ? 20.84851 -18.63789 3.77168   1.000 14.46859  ? 106 ILE A O   1 
ATOM   833  C CB  . ILE A 1 106 ? 17.82442 -17.35069 4.55642   1.000 8.97666   ? 106 ILE A CB  1 
ATOM   834  C CG1 . ILE A 1 106 ? 17.64949 -17.69144 3.08660   1.000 12.51129  ? 106 ILE A CG1 1 
ATOM   835  C CG2 . ILE A 1 106 ? 17.08210 -16.12139 4.91325   1.000 16.48073  ? 106 ILE A CG2 1 
ATOM   836  C CD1 . ILE A 1 106 ? 16.25294 -18.34068 2.74781   1.000 12.51960  ? 106 ILE A CD1 1 
ATOM   837  N N   . GLN A 1 107 ? 19.92261 -19.28373 5.70257   1.000 11.28986  ? 107 GLN A N   1 
ATOM   838  C CA  . GLN A 1 107 ? 20.42884 -20.63662 5.72799   1.000 12.17924  ? 107 GLN A CA  1 
ATOM   839  C C   . GLN A 1 107 ? 19.43923 -21.57849 5.06207   1.000 17.51972  ? 107 GLN A C   1 
ATOM   840  O O   . GLN A 1 107 ? 18.22967 -21.28975 4.98137   1.000 13.06992  ? 107 GLN A O   1 
ATOM   841  C CB  . GLN A 1 107 ? 20.67220 -21.12517 7.15884   1.000 13.55984  ? 107 GLN A CB  1 
ATOM   842  C CG  . GLN A 1 107 ? 21.74008 -20.45765 7.95346   1.000 17.82249  ? 107 GLN A CG  1 
ATOM   843  C CD  . GLN A 1 107 ? 23.13184 -20.88416 7.48613   1.000 18.08505  ? 107 GLN A CD  1 
ATOM   844  O OE1 . GLN A 1 107 ? 23.29966 -21.95914 6.86736   1.000 19.29214  ? 107 GLN A OE1 1 
ATOM   845  N NE2 . GLN A 1 107 ? 24.13884 -20.09978 7.85708   1.000 18.22228  ? 107 GLN A NE2 1 
ATOM   846  N N   . PRO A 1 108 ? 19.96410 -22.67267 4.53805   1.000 10.56540  ? 108 PRO A N   1 
ATOM   847  C CA  . PRO A 1 108 ? 19.09687 -23.70838 3.99745   1.000 11.31545  ? 108 PRO A CA  1 
ATOM   848  C C   . PRO A 1 108 ? 18.15695 -24.20318 5.08292   1.000 11.93874  ? 108 PRO A C   1 
ATOM   849  O O   . PRO A 1 108 ? 18.51898 -24.25990 6.26967   1.000 16.64722  ? 108 PRO A O   1 
ATOM   850  C CB  . PRO A 1 108 ? 20.08820 -24.78691 3.52079   1.000 14.41163  ? 108 PRO A CB  1 
ATOM   851  C CG  . PRO A 1 108 ? 21.39978 -24.46315 4.20758   1.000 19.52206  ? 108 PRO A CG  1 
ATOM   852  C CD  . PRO A 1 108 ? 21.40355 -22.98864 4.38735   1.000 19.81824  ? 108 PRO A CD  1 
ATOM   853  N N   . GLY A 1 109 ? 16.91967 -24.46551 4.67098   1.000 11.72431  ? 109 GLY A N   1 
ATOM   854  C CA  . GLY A 1 109 ? 15.86447 -24.89705 5.54073   1.000 15.41432  ? 109 GLY A CA  1 
ATOM   855  C C   . GLY A 1 109 ? 14.94832 -23.77860 5.98190   1.000 17.61320  ? 109 GLY A C   1 
ATOM   856  O O   . GLY A 1 109 ? 13.85658 -24.04423 6.45198   1.000 15.16459  ? 109 GLY A O   1 
ATOM   857  N N   . GLN A 1 110 ? 15.38226 -22.53057 5.86134   1.000 10.06469  ? 110 GLN A N   1 
ATOM   858  C CA  . GLN A 1 110 ? 14.54067 -21.38360 6.19245   1.000 8.70037   ? 110 GLN A CA  1 
ATOM   859  C C   . GLN A 1 110 ? 13.52128 -21.11950 5.08333   1.000 8.33961   ? 110 GLN A C   1 
ATOM   860  O O   . GLN A 1 110 ? 13.76585 -21.34271 3.89946   1.000 12.46064  ? 110 GLN A O   1 
ATOM   861  C CB  . GLN A 1 110 ? 15.39595 -20.13388 6.39433   1.000 15.64163  ? 110 GLN A CB  1 
ATOM   862  C CG  . GLN A 1 110 ? 16.23946 -20.23416 7.62679   1.000 18.71604  ? 110 GLN A CG  1 
ATOM   863  C CD  . GLN A 1 110 ? 15.38221 -20.40700 8.86012   1.000 31.75566  ? 110 GLN A CD  1 
ATOM   864  O OE1 . GLN A 1 110 ? 14.58622 -19.50706 9.19864   1.000 29.45202  ? 110 GLN A OE1 1 
ATOM   865  N NE2 . GLN A 1 110 ? 15.50882 -21.58121 9.53051   1.000 24.04408  ? 110 GLN A NE2 1 
ATOM   866  N N   . THR A 1 111 ? 12.37632 -20.59014 5.48684   1.000 9.20165   ? 111 THR A N   1 
ATOM   867  C CA  . THR A 1 111 ? 11.27730 -20.33999 4.55533   1.000 10.48948  ? 111 THR A CA  1 
ATOM   868  C C   . THR A 1 111 ? 11.15281 -18.84924 4.31947   1.000 12.11546  ? 111 THR A C   1 
ATOM   869  O O   . THR A 1 111 ? 11.72082 -18.03279 5.06176   1.000 14.67463  ? 111 THR A O   1 
ATOM   870  C CB  . THR A 1 111 ? 9.95757  -20.87127 5.12423   1.000 10.83895  ? 111 THR A CB  1 
ATOM   871  O OG1 . THR A 1 111 ? 9.81870  -20.28851 6.40847   1.000 12.71951  ? 111 THR A OG1 1 
ATOM   872  C CG2 . THR A 1 111 ? 9.96878  -22.39289 5.28544   1.000 10.78436  ? 111 THR A CG2 1 
ATOM   873  N N   . PHE A 1 112 ? 10.37632 -18.49881 3.28292   1.000 10.80805  ? 112 PHE A N   1 
ATOM   874  C CA  . PHE A 1 112 ? 10.12246 -17.11562 2.94292   1.000 12.11095  ? 112 PHE A CA  1 
ATOM   875  C C   . PHE A 1 112 ? 8.95868  -17.06205 1.97884   1.000 12.92767  ? 112 PHE A C   1 
ATOM   876  O O   . PHE A 1 112 ? 8.60476  -18.05398 1.33252   1.000 10.06260  ? 112 PHE A O   1 
ATOM   877  C CB  . PHE A 1 112 ? 11.36793 -16.40444 2.32957   1.000 11.82512  ? 112 PHE A CB  1 
ATOM   878  C CG  . PHE A 1 112 ? 11.96970 -17.11908 1.13537   1.000 15.80219  ? 112 PHE A CG  1 
ATOM   879  C CD1 . PHE A 1 112 ? 12.96187 -18.08995 1.31005   1.000 20.00899  ? 112 PHE A CD1 1 
ATOM   880  C CD2 . PHE A 1 112 ? 11.60499 -16.78892 -0.15849  1.000 8.75713   ? 112 PHE A CD2 1 
ATOM   881  C CE1 . PHE A 1 112 ? 13.56339 -18.72225 0.23281   1.000 17.04806  ? 112 PHE A CE1 1 
ATOM   882  C CE2 . PHE A 1 112 ? 12.18860 -17.44463 -1.25277  1.000 13.86280  ? 112 PHE A CE2 1 
ATOM   883  C CZ  . PHE A 1 112 ? 13.19120 -18.41926 -1.03758  1.000 14.43608  ? 112 PHE A CZ  1 
ATOM   884  N N   . SER A 1 113 ? 8.37665  -15.87846 1.89722   1.000 11.67142  ? 113 SER A N   1 
ATOM   885  C CA  . SER A 1 113 ? 7.30932  -15.59739 0.94985   1.000 13.66999  ? 113 SER A CA  1 
ATOM   886  C C   . SER A 1 113 ? 7.89499  -15.09538 -0.35109  1.000 12.08362  ? 113 SER A C   1 
ATOM   887  O O   . SER A 1 113 ? 8.84963  -14.32632 -0.33857  1.000 13.65872  ? 113 SER A O   1 
ATOM   888  C CB  . SER A 1 113 ? 6.40119  -14.52820 1.52954   1.000 14.04473  ? 113 SER A CB  1 
ATOM   889  O OG  . SER A 1 113 ? 5.84699  -14.97318 2.72534   1.000 13.90707  ? 113 SER A OG  1 
ATOM   890  N N   . VAL A 1 114 ? 7.28650  -15.48144 -1.46586  1.000 11.23314  ? 114 VAL A N   1 
ATOM   891  C CA  . VAL A 1 114 ? 7.71820  -15.00020 -2.78102  1.000 12.06541  ? 114 VAL A CA  1 
ATOM   892  C C   . VAL A 1 114 ? 6.58426  -14.18230 -3.37431  1.000 13.07474  ? 114 VAL A C   1 
ATOM   893  O O   . VAL A 1 114 ? 5.44862  -14.65579 -3.41542  1.000 13.64811  ? 114 VAL A O   1 
ATOM   894  C CB  . VAL A 1 114 ? 8.07260  -16.15814 -3.72429  1.000 14.10754  ? 114 VAL A CB  1 
ATOM   895  C CG1 . VAL A 1 114 ? 8.22862  -15.61788 -5.16352  1.000 10.83232  ? 114 VAL A CG1 1 
ATOM   896  C CG2 . VAL A 1 114 ? 9.33554  -16.96107 -3.21918  1.000 12.62722  ? 114 VAL A CG2 1 
ATOM   897  N N   . LEU A 1 115 ? 6.89702  -12.97045 -3.84739  1.000 10.45734  ? 115 LEU A N   1 
ATOM   898  C CA  . LEU A 1 115 ? 5.93746  -12.14292 -4.58413  1.000 12.06162  ? 115 LEU A CA  1 
ATOM   899  C C   . LEU A 1 115 ? 6.29104  -12.29389 -6.05351  1.000 14.57271  ? 115 LEU A C   1 
ATOM   900  O O   . LEU A 1 115 ? 7.26708  -11.69659 -6.54166  1.000 16.70049  ? 115 LEU A O   1 
ATOM   901  C CB  . LEU A 1 115 ? 5.99154  -10.69984 -4.10126  1.000 11.22053  ? 115 LEU A CB  1 
ATOM   902  C CG  . LEU A 1 115 ? 4.95951  -9.88441  -4.83953  1.000 11.12555  ? 115 LEU A CG  1 
ATOM   903  C CD1 . LEU A 1 115 ? 3.48152  -10.35659 -4.41121  1.000 13.80201  ? 115 LEU A CD1 1 
ATOM   904  C CD2 . LEU A 1 115 ? 5.16035  -8.45118  -4.46470  1.000 16.23120  ? 115 LEU A CD2 1 
ATOM   905  N N   . ALA A 1 116 ? 5.58875  -13.19105 -6.73678  1.000 10.87672  ? 116 ALA A N   1 
ATOM   906  C CA  . ALA A 1 116 ? 5.91705  -13.44174 -8.12312  1.000 10.47770  ? 116 ALA A CA  1 
ATOM   907  C C   . ALA A 1 116 ? 5.40406  -12.25546 -8.95695  1.000 18.93312  ? 116 ALA A C   1 
ATOM   908  O O   . ALA A 1 116 ? 4.28437  -11.78880 -8.74837  1.000 20.52333  ? 116 ALA A O   1 
ATOM   909  C CB  . ALA A 1 116 ? 5.33392  -14.76711 -8.58690  1.000 15.68386  ? 116 ALA A CB  1 
ATOM   910  N N   . CYS A 1 117 ? 6.24888  -11.73184 -9.85688  1.000 14.07517  ? 117 CYS A N   1 
ATOM   911  C CA  . CYS A 1 117 ? 5.93033  -10.50619 -10.58914 1.000 15.63720  ? 117 CYS A CA  1 
ATOM   912  C C   . CYS A 1 117 ? 6.30093  -10.64555 -12.06204 1.000 15.26428  ? 117 CYS A C   1 
ATOM   913  O O   . CYS A 1 117 ? 7.23407  -11.36686 -12.42530 1.000 15.57980  ? 117 CYS A O   1 
ATOM   914  C CB  . CYS A 1 117 ? 6.67706  -9.28744  -10.03456 1.000 17.67726  ? 117 CYS A CB  1 
ATOM   915  S SG  . CYS A 1 117 ? 6.34614  -8.81924  -8.38079  1.000 21.46480  ? 117 CYS A SG  1 
ATOM   916  N N   . TYR A 1 118 ? 5.55067  -9.93705  -12.91926 1.000 22.10181  ? 118 TYR A N   1 
ATOM   917  C CA  . TYR A 1 118 ? 5.82778  -9.85373  -14.35235 1.000 16.38507  ? 118 TYR A CA  1 
ATOM   918  C C   . TYR A 1 118 ? 5.63882  -8.39934  -14.77660 1.000 18.27361  ? 118 TYR A C   1 
ATOM   919  O O   . TYR A 1 118 ? 4.65977  -7.75582  -14.38807 1.000 22.67851  ? 118 TYR A O   1 
ATOM   920  C CB  . TYR A 1 118 ? 4.92060  -10.80494 -15.17941 1.000 18.81841  ? 118 TYR A CB  1 
ATOM   921  C CG  . TYR A 1 118 ? 5.12320  -12.23546 -14.73235 1.000 16.77677  ? 118 TYR A CG  1 
ATOM   922  C CD1 . TYR A 1 118 ? 6.13716  -13.01877 -15.30409 1.000 18.35569  ? 118 TYR A CD1 1 
ATOM   923  C CD2 . TYR A 1 118 ? 4.41713  -12.75000 -13.65054 1.000 18.46911  ? 118 TYR A CD2 1 
ATOM   924  C CE1 . TYR A 1 118 ? 6.38618  -14.31147 -14.87093 1.000 15.80808  ? 118 TYR A CE1 1 
ATOM   925  C CE2 . TYR A 1 118 ? 4.67975  -14.05120 -13.19318 1.000 19.07847  ? 118 TYR A CE2 1 
ATOM   926  C CZ  . TYR A 1 118 ? 5.66249  -14.80246 -13.80212 1.000 15.08696  ? 118 TYR A CZ  1 
ATOM   927  O OH  . TYR A 1 118 ? 5.96807  -16.09211 -13.36363 1.000 16.30399  ? 118 TYR A OH  1 
ATOM   928  N N   . ASN A 1 119 ? 6.59949  -7.87503  -15.54634 1.000 21.85918  ? 119 ASN A N   1 
ATOM   929  C CA  . ASN A 1 119 ? 6.53014  -6.49399  -16.04896 1.000 20.39383  ? 119 ASN A CA  1 
ATOM   930  C C   . ASN A 1 119 ? 6.37160  -5.47833  -14.91118 1.000 18.21290  ? 119 ASN A C   1 
ATOM   931  O O   . ASN A 1 119 ? 5.66149  -4.47362  -15.03923 1.000 23.90737  ? 119 ASN A O   1 
ATOM   932  C CB  . ASN A 1 119 ? 5.39244  -6.34191  -17.07014 1.000 26.91688  ? 119 ASN A CB  1 
ATOM   933  C CG  . ASN A 1 119 ? 5.38496  -7.44632  -18.11564 1.000 17.77049  ? 119 ASN A CG  1 
ATOM   934  O OD1 . ASN A 1 119 ? 6.24264  -7.48863  -19.00758 1.000 39.85138  ? 119 ASN A OD1 1 
ATOM   935  N ND2 . ASN A 1 119 ? 4.36297  -8.31796  -18.05180 1.000 31.81771  ? 119 ASN A ND2 1 
ATOM   936  N N   . GLY A 1 120 ? 7.01391  -5.74917  -13.77212 1.000 17.82176  ? 120 GLY A N   1 
ATOM   937  C CA  . GLY A 1 120 ? 6.93709  -4.90577  -12.60079 1.000 21.98693  ? 120 GLY A CA  1 
ATOM   938  C C   . GLY A 1 120 ? 5.63560  -4.97266  -11.83781 1.000 18.43704  ? 120 GLY A C   1 
ATOM   939  O O   . GLY A 1 120 ? 5.45886  -4.21844  -10.86986 1.000 24.34287  ? 120 GLY A O   1 
ATOM   940  N N   . SER A 1 121 ? 4.71861  -5.85711  -12.24730 1.000 18.92703  ? 121 SER A N   1 
ATOM   941  C CA  . SER A 1 121 ? 3.39276  -5.94590  -11.64656 1.000 22.16494  ? 121 SER A CA  1 
ATOM   942  C C   . SER A 1 121 ? 3.24657  -7.22593  -10.82830 1.000 21.17183  ? 121 SER A C   1 
ATOM   943  O O   . SER A 1 121 ? 3.46469  -8.32709  -11.35433 1.000 24.64934  ? 121 SER A O   1 
ATOM   944  C CB  . SER A 1 121 ? 2.31391  -5.88869  -12.72749 1.000 24.91108  ? 121 SER A CB  1 
ATOM   945  O OG  . SER A 1 121 ? 2.36601  -4.64636  -13.39780 1.000 35.32110  ? 121 SER A OG  1 
ATOM   946  N N   . PRO A 1 122 ? 2.92341  -7.13238  -9.54737  1.000 18.96382  ? 122 PRO A N   1 
ATOM   947  C CA  . PRO A 1 122 ? 2.79114  -8.36014  -8.74520  1.000 28.24842  ? 122 PRO A CA  1 
ATOM   948  C C   . PRO A 1 122 ? 1.64746  -9.22648  -9.24301  1.000 24.90528  ? 122 PRO A C   1 
ATOM   949  O O   . PRO A 1 122 ? 0.56230  -8.72870  -9.54898  1.000 24.64149  ? 122 PRO A O   1 
ATOM   950  C CB  . PRO A 1 122 ? 2.54717  -7.83315  -7.33498  1.000 22.55844  ? 122 PRO A CB  1 
ATOM   951  C CG  . PRO A 1 122 ? 3.29367  -6.53842  -7.29695  1.000 32.97776  ? 122 PRO A CG  1 
ATOM   952  C CD  . PRO A 1 122 ? 3.03910  -5.93609  -8.69337  1.000 22.37515  ? 122 PRO A CD  1 
ATOM   953  N N   . SER A 1 123 ? 1.90539  -10.53254 -9.34884  1.000 28.37410  ? 123 SER A N   1 
ATOM   954  C CA  . SER A 1 123 ? 0.88114  -11.46859 -9.78354  1.000 23.63994  ? 123 SER A CA  1 
ATOM   955  C C   . SER A 1 123 ? 0.37923  -12.42864 -8.70609  1.000 22.98647  ? 123 SER A C   1 
ATOM   956  O O   . SER A 1 123 ? -0.80501 -12.80332 -8.74387  1.000 18.78439  ? 123 SER A O   1 
ATOM   957  C CB  . SER A 1 123 ? 1.37840  -12.28781 -10.96960 1.000 26.50293  ? 123 SER A CB  1 
ATOM   958  O OG  . SER A 1 123 ? 2.47759  -13.07233 -10.59582 1.000 39.56672  ? 123 SER A OG  1 
ATOM   959  N N   . GLY A 1 124 ? 1.21952  -12.85608 -7.76496  1.000 15.38746  ? 124 GLY A N   1 
ATOM   960  C CA  . GLY A 1 124 ? 0.76881  -13.82450 -6.78133  1.000 12.18232  ? 124 GLY A CA  1 
ATOM   961  C C   . GLY A 1 124 ? 1.78788  -13.95433 -5.68132  1.000 21.40738  ? 124 GLY A C   1 
ATOM   962  O O   . GLY A 1 124 ? 2.94513  -13.55560 -5.83853  1.000 14.96592  ? 124 GLY A O   1 
ATOM   963  N N   . VAL A 1 125 ? 1.34041  -14.49641 -4.55778  1.000 15.65278  ? 125 VAL A N   1 
ATOM   964  C CA  . VAL A 1 125 ? 2.21653  -14.68999 -3.40203  1.000 12.89237  ? 125 VAL A CA  1 
ATOM   965  C C   . VAL A 1 125 ? 2.15020  -16.14843 -2.94794  1.000 14.90652  ? 125 VAL A C   1 
ATOM   966  O O   . VAL A 1 125 ? 1.07792  -16.75841 -2.89445  1.000 15.87491  ? 125 VAL A O   1 
ATOM   967  C CB  . VAL A 1 125 ? 1.86181  -13.72222 -2.25073  1.000 17.51480  ? 125 VAL A CB  1 
ATOM   968  C CG1 . VAL A 1 125 ? 0.56909  -14.11179 -1.65024  1.000 25.86650  ? 125 VAL A CG1 1 
ATOM   969  C CG2 . VAL A 1 125 ? 2.90575  -13.75093 -1.18372  1.000 18.89423  ? 125 VAL A CG2 1 
ATOM   970  N N   . TYR A 1 126 ? 3.31039  -16.73816 -2.66353  1.000 16.34200  ? 126 TYR A N   1 
ATOM   971  C CA  . TYR A 1 126 ? 3.32651  -18.10017 -2.13766  1.000 16.42618  ? 126 TYR A CA  1 
ATOM   972  C C   . TYR A 1 126 ? 4.50622  -18.24874 -1.20448  1.000 18.40577  ? 126 TYR A C   1 
ATOM   973  O O   . TYR A 1 126 ? 5.41237  -17.41175 -1.16454  1.000 16.02664  ? 126 TYR A O   1 
ATOM   974  C CB  . TYR A 1 126 ? 3.36880  -19.18883 -3.23813  1.000 15.81367  ? 126 TYR A CB  1 
ATOM   975  C CG  . TYR A 1 126 ? 4.44891  -19.01498 -4.25190  1.000 16.89615  ? 126 TYR A CG  1 
ATOM   976  C CD1 . TYR A 1 126 ? 5.71909  -19.52281 -4.04167  1.000 14.34358  ? 126 TYR A CD1 1 
ATOM   977  C CD2 . TYR A 1 126 ? 4.19433  -18.33988 -5.43196  1.000 21.07532  ? 126 TYR A CD2 1 
ATOM   978  C CE1 . TYR A 1 126 ? 6.71054  -19.36028 -4.99657  1.000 14.34390  ? 126 TYR A CE1 1 
ATOM   979  C CE2 . TYR A 1 126 ? 5.18217  -18.15974 -6.37949  1.000 21.52331  ? 126 TYR A CE2 1 
ATOM   980  C CZ  . TYR A 1 126 ? 6.42135  -18.66998 -6.15048  1.000 16.35857  ? 126 TYR A CZ  1 
ATOM   981  O OH  . TYR A 1 126 ? 7.37978  -18.50972 -7.11669  1.000 23.42749  ? 126 TYR A OH  1 
ATOM   982  N N   . GLN A 1 127 ? 4.49187  -19.35323 -0.46582  1.000 13.44112  ? 127 GLN A N   1 
ATOM   983  C CA  . GLN A 1 127 ? 5.56064  -19.65625 0.47648   1.000 14.86909  ? 127 GLN A CA  1 
ATOM   984  C C   . GLN A 1 127 ? 6.47741  -20.73362 -0.07732  1.000 11.81660  ? 127 GLN A C   1 
ATOM   985  O O   . GLN A 1 127 ? 6.05474  -21.65145 -0.78988  1.000 19.14277  ? 127 GLN A O   1 
ATOM   986  C CB  . GLN A 1 127 ? 4.92441  -20.10431 1.80059   1.000 21.39468  ? 127 GLN A CB  1 
ATOM   987  C CG  . GLN A 1 127 ? 5.82739  -20.15261 2.95801   1.000 34.07815  ? 127 GLN A CG  1 
ATOM   988  C CD  . GLN A 1 127 ? 6.01973  -18.77618 3.58479   1.000 26.44358  ? 127 GLN A CD  1 
ATOM   989  O OE1 . GLN A 1 127 ? 5.64138  -17.72393 3.00865   1.000 17.03597  ? 127 GLN A OE1 1 
ATOM   990  N NE2 . GLN A 1 127 ? 6.64364  -18.77047 4.74806   1.000 21.88204  ? 127 GLN A NE2 1 
ATOM   991  N N   . CYS A 1 128 ? 7.74966  -20.64408 0.26712   1.000 12.71044  ? 128 CYS A N   1 
ATOM   992  C CA  . CYS A 1 128 ? 8.62850  -21.74310 -0.09310  1.000 19.25372  ? 128 CYS A CA  1 
ATOM   993  C C   . CYS A 1 128 ? 9.80220  -21.74158 0.86329   1.000 13.99377  ? 128 CYS A C   1 
ATOM   994  O O   . CYS A 1 128 ? 9.86951  -20.92407 1.78085   1.000 18.42928  ? 128 CYS A O   1 
ATOM   995  C CB  . CYS A 1 128 ? 8.96982  -21.67714 -1.56970  1.000 34.68210  ? 128 CYS A CB  1 
ATOM   996  S SG  . CYS A 1 128 ? 9.91242  -20.32488 -1.84636  1.000 35.52547  ? 128 CYS A SG  1 
ATOM   997  N N   . ALA A 1 129 ? 10.66851 -22.74347 0.71078   1.000 15.71060  ? 129 ALA A N   1 
ATOM   998  C CA  . ALA A 1 129 ? 11.84804 -22.89570 1.56147   1.000 13.21825  ? 129 ALA A CA  1 
ATOM   999  C C   . ALA A 1 129 ? 13.11003 -22.90700 0.71419   1.000 12.76104  ? 129 ALA A C   1 
ATOM   1000 O O   . ALA A 1 129 ? 13.12015 -23.39485 -0.42444  1.000 16.62254  ? 129 ALA A O   1 
ATOM   1001 C CB  . ALA A 1 129 ? 11.79596 -24.19916 2.40666   1.000 15.46576  ? 129 ALA A CB  1 
ATOM   1002 N N   . MET A 1 130 ? 14.21405 -22.47992 1.31904   1.000 12.82741  ? 130 MET A N   1 
ATOM   1003 C CA  . MET A 1 130 ? 15.47616 -22.67714 0.65101   1.000 10.58728  ? 130 MET A CA  1 
ATOM   1004 C C   . MET A 1 130 ? 15.82263 -24.15503 0.87646   1.000 10.60938  ? 130 MET A C   1 
ATOM   1005 O O   . MET A 1 130 ? 15.98763 -24.58848 2.02759   1.000 12.07066  ? 130 MET A O   1 
ATOM   1006 C CB  . MET A 1 130 ? 16.53266 -21.70812 1.17871   1.000 12.10506  ? 130 MET A CB  1 
ATOM   1007 C CG  . MET A 1 130 ? 17.95408 -22.18384 0.75360   1.000 13.85573  ? 130 MET A CG  1 
ATOM   1008 S SD  . MET A 1 130 ? 18.12811 -21.53317 -0.96302  1.000 13.62173  ? 130 MET A SD  1 
ATOM   1009 C CE  . MET A 1 130 ? 17.34590 -19.92739 -0.98983  1.000 19.08460  ? 130 MET A CE  1 
ATOM   1010 N N   . ARG A 1 131 ? 15.92326 -24.93082 -0.20251  1.000 11.36830  ? 131 ARG A N   1 
ATOM   1011 C CA  . ARG A 1 131 ? 16.20435 -26.36299 -0.02715  1.000 13.48091  ? 131 ARG A CA  1 
ATOM   1012 C C   . ARG A 1 131 ? 17.63680 -26.57040 0.47359   1.000 13.01874  ? 131 ARG A C   1 
ATOM   1013 O O   . ARG A 1 131 ? 18.52365 -25.71531 0.29104   1.000 10.59718  ? 131 ARG A O   1 
ATOM   1014 C CB  . ARG A 1 131 ? 15.99386 -27.12131 -1.34109  1.000 13.99395  ? 131 ARG A CB  1 
ATOM   1015 C CG  . ARG A 1 131 ? 14.62517 -26.96817 -2.00394  1.000 11.48515  ? 131 ARG A CG  1 
ATOM   1016 C CD  . ARG A 1 131 ? 13.49328 -27.45524 -1.10959  1.000 10.41240  ? 131 ARG A CD  1 
ATOM   1017 N NE  . ARG A 1 131 ? 13.76594 -28.74044 -0.48106  1.000 12.36072  ? 131 ARG A NE  1 
ATOM   1018 C CZ  . ARG A 1 131 ? 13.02966 -29.25372 0.50402   1.000 17.09788  ? 131 ARG A CZ  1 
ATOM   1019 N NH1 . ARG A 1 131 ? 11.96269 -28.60645 0.99095   1.000 13.39726  ? 131 ARG A NH1 1 
ATOM   1020 N NH2 . ARG A 1 131 ? 13.38532 -30.43624 1.03529   1.000 14.33613  ? 131 ARG A NH2 1 
ATOM   1021 N N   . PRO A 1 132 ? 17.91830 -27.74242 1.06675   1.000 9.71544   ? 132 PRO A N   1 
ATOM   1022 C CA  . PRO A 1 132 ? 19.30229 -28.06824 1.43009   1.000 12.66249  ? 132 PRO A CA  1 
ATOM   1023 C C   . PRO A 1 132 ? 20.27641 -27.96934 0.27912   1.000 11.89176  ? 132 PRO A C   1 
ATOM   1024 O O   . PRO A 1 132 ? 21.45815 -27.67706 0.51870   1.000 12.12494  ? 132 PRO A O   1 
ATOM   1025 C CB  . PRO A 1 132 ? 19.18703 -29.50700 1.96615   1.000 13.29166  ? 132 PRO A CB  1 
ATOM   1026 C CG  . PRO A 1 132 ? 17.82198 -29.54881 2.53312   1.000 15.22982  ? 132 PRO A CG  1 
ATOM   1027 C CD  . PRO A 1 132 ? 16.94138 -28.70890 1.63010   1.000 11.39648  ? 132 PRO A CD  1 
ATOM   1028 N N   . ASN A 1 133 ? 19.82164 -28.17858 -0.96368  1.000 10.85724  ? 133 ASN A N   1 
ATOM   1029 C CA  . ASN A 1 133 ? 20.72166 -28.04833 -2.10685  1.000 12.63851  ? 133 ASN A CA  1 
ATOM   1030 C C   . ASN A 1 133 ? 20.69048 -26.65095 -2.68375  1.000 13.70816  ? 133 ASN A C   1 
ATOM   1031 O O   . ASN A 1 133 ? 21.20062 -26.42797 -3.78272  1.000 11.25327  ? 133 ASN A O   1 
ATOM   1032 C CB  . ASN A 1 133 ? 20.41376 -29.11325 -3.18035  1.000 12.06664  ? 133 ASN A CB  1 
ATOM   1033 C CG  . ASN A 1 133 ? 19.06787 -28.88066 -3.88256  1.000 13.16933  ? 133 ASN A CG  1 
ATOM   1034 O OD1 . ASN A 1 133 ? 18.34468 -27.96721 -3.55125  1.000 11.89222  ? 133 ASN A OD1 1 
ATOM   1035 N ND2 . ASN A 1 133 ? 18.72309 -29.75152 -4.81906  1.000 18.20819  ? 133 ASN A ND2 1 
ATOM   1036 N N   . PHE A 1 134 ? 20.10538 -25.69972 -1.96717  1.000 11.41225  ? 134 PHE A N   1 
ATOM   1037 C CA  . PHE A 1 134 ? 20.14696 -24.28621 -2.34272  1.000 11.73143  ? 134 PHE A CA  1 
ATOM   1038 C C   . PHE A 1 134 ? 19.39297 -23.97895 -3.63234  1.000 13.52648  ? 134 PHE A C   1 
ATOM   1039 O O   . PHE A 1 134 ? 19.62906 -22.93833 -4.27120  1.000 13.04175  ? 134 PHE A O   1 
ATOM   1040 C CB  . PHE A 1 134 ? 21.58122 -23.78013 -2.42203  1.000 11.64606  ? 134 PHE A CB  1 
ATOM   1041 C CG  . PHE A 1 134 ? 22.24403 -23.65580 -1.06159  1.000 10.95862  ? 134 PHE A CG  1 
ATOM   1042 C CD1 . PHE A 1 134 ? 21.84857 -22.65328 -0.19985  1.000 13.86465  ? 134 PHE A CD1 1 
ATOM   1043 C CD2 . PHE A 1 134 ? 23.17880 -24.56519 -0.64393  1.000 14.78518  ? 134 PHE A CD2 1 
ATOM   1044 C CE1 . PHE A 1 134 ? 22.41757 -22.52489 1.07006   1.000 14.79939  ? 134 PHE A CE1 1 
ATOM   1045 C CE2 . PHE A 1 134 ? 23.79162 -24.45886 0.62698   1.000 15.22649  ? 134 PHE A CE2 1 
ATOM   1046 C CZ  . PHE A 1 134 ? 23.41974 -23.43271 1.48166   1.000 17.40652  ? 134 PHE A CZ  1 
ATOM   1047 N N   . THR A 1 135 ? 18.45258 -24.81605 -4.01058  1.000 10.74551  ? 135 THR A N   1 
ATOM   1048 C CA  . THR A 1 135 ? 17.40110 -24.43083 -4.94191  1.000 8.70399   ? 135 THR A CA  1 
ATOM   1049 C C   . THR A 1 135 ? 16.12937 -24.10314 -4.16382  1.000 16.53627  ? 135 THR A C   1 
ATOM   1050 O O   . THR A 1 135 ? 16.00474 -24.39014 -2.97135  1.000 12.97616  ? 135 THR A O   1 
ATOM   1051 C CB  . THR A 1 135 ? 17.11508 -25.56233 -5.92812  1.000 12.19691  ? 135 THR A CB  1 
ATOM   1052 O OG1 . THR A 1 135 ? 16.54118 -26.67441 -5.22603  1.000 14.06253  ? 135 THR A OG1 1 
ATOM   1053 C CG2 . THR A 1 135 ? 18.42583 -26.07648 -6.60328  1.000 11.74333  ? 135 THR A CG2 1 
ATOM   1054 N N   . ILE A 1 136 ? 15.18015 -23.48633 -4.85839  1.000 9.61308   ? 136 ILE A N   1 
ATOM   1055 C CA  . ILE A 1 136 ? 13.82508 -23.35932 -4.33436  1.000 10.80789  ? 136 ILE A CA  1 
ATOM   1056 C C   . ILE A 1 136 ? 12.83003 -23.94849 -5.31930  1.000 13.17816  ? 136 ILE A C   1 
ATOM   1057 O O   . ILE A 1 136 ? 13.00892 -23.90434 -6.54242  1.000 12.36280  ? 136 ILE A O   1 
ATOM   1058 C CB  . ILE A 1 136 ? 13.46848 -21.90099 -3.94367  1.000 19.19137  ? 136 ILE A CB  1 
ATOM   1059 C CG1 . ILE A 1 136 ? 13.16813 -21.01385 -5.14941  1.000 15.91633  ? 136 ILE A CG1 1 
ATOM   1060 C CG2 . ILE A 1 136 ? 14.65819 -21.25430 -3.13998  1.000 15.48448  ? 136 ILE A CG2 1 
ATOM   1061 C CD1 . ILE A 1 136 ? 12.64795 -19.65413 -4.72249  1.000 17.53195  ? 136 ILE A CD1 1 
ATOM   1062 N N   . LYS A 1 137 ? 11.76903 -24.54281 -4.76542  1.000 12.64518  ? 137 LYS A N   1 
ATOM   1063 C CA  . LYS A 1 137 ? 10.70730 -25.11784 -5.59478  1.000 11.27664  ? 137 LYS A CA  1 
ATOM   1064 C C   . LYS A 1 137 ? 9.65006  -24.03588 -5.75431  1.000 13.66444  ? 137 LYS A C   1 
ATOM   1065 O O   . LYS A 1 137 ? 8.65076  -23.98287 -5.03790  1.000 16.44595  ? 137 LYS A O   1 
ATOM   1066 C CB  . LYS A 1 137 ? 10.15869 -26.38834 -4.96580  1.000 13.51341  ? 137 LYS A CB  1 
ATOM   1067 C CG  . LYS A 1 137 ? 11.25230 -27.43532 -4.79128  1.000 16.53746  ? 137 LYS A CG  1 
ATOM   1068 C CD  . LYS A 1 137 ? 10.71894 -28.87258 -4.78209  1.000 30.72534  ? 137 LYS A CD  1 
ATOM   1069 C CE  . LYS A 1 137 ? 11.34371 -29.66640 -3.63257  1.000 43.60106  ? 137 LYS A CE  1 
ATOM   1070 N NZ  . LYS A 1 137 ? 11.32514 -31.15031 -3.84559  1.000 52.29195  ? 137 LYS A NZ  1 
ATOM   1071 N N   . GLY A 1 138 ? 9.90409  -23.13451 -6.70976  1.000 12.92869  ? 138 GLY A N   1 
ATOM   1072 C CA  . GLY A 1 138 ? 9.08722  -21.95938 -6.88875  1.000 14.96744  ? 138 GLY A CA  1 
ATOM   1073 C C   . GLY A 1 138 ? 8.06691  -22.17584 -7.99279  1.000 15.06503  ? 138 GLY A C   1 
ATOM   1074 O O   . GLY A 1 138 ? 7.91208  -23.27627 -8.53858  1.000 15.04265  ? 138 GLY A O   1 
ATOM   1075 N N   . SER A 1 139 ? 7.39826  -21.08870 -8.35294  1.000 11.60379  ? 139 SER A N   1 
ATOM   1076 C CA  . SER A 1 139 ? 6.49017  -21.10758 -9.51298  1.000 13.70828  ? 139 SER A CA  1 
ATOM   1077 C C   . SER A 1 139 ? 6.78962  -19.83602 -10.30775 1.000 11.91089  ? 139 SER A C   1 
ATOM   1078 O O   . SER A 1 139 ? 6.36307  -18.72561 -9.94801  1.000 11.91244  ? 139 SER A O   1 
ATOM   1079 C CB  . SER A 1 139 ? 5.02868  -21.20369 -9.09691  1.000 12.44426  ? 139 SER A CB  1 
ATOM   1080 O OG  . SER A 1 139 ? 4.22520  -21.12473 -10.27807 1.000 16.03877  ? 139 SER A OG  1 
ATOM   1081 N N   . PHE A 1 140 ? 7.53733  -20.02175 -11.39635 1.000 12.96211  ? 140 PHE A N   1 
ATOM   1082 C CA  . PHE A 1 140 ? 8.15175  -18.92396 -12.12386 1.000 14.78520  ? 140 PHE A CA  1 
ATOM   1083 C C   . PHE A 1 140 ? 8.14286  -19.21141 -13.61780 1.000 10.79071  ? 140 PHE A C   1 
ATOM   1084 O O   . PHE A 1 140 ? 8.57977  -20.28903 -14.05110 1.000 14.93021  ? 140 PHE A O   1 
ATOM   1085 C CB  . PHE A 1 140 ? 9.61228  -18.72677 -11.67052 1.000 13.35286  ? 140 PHE A CB  1 
ATOM   1086 C CG  . PHE A 1 140 ? 9.78272  -18.14224 -10.27138 1.000 13.10102  ? 140 PHE A CG  1 
ATOM   1087 C CD1 . PHE A 1 140 ? 9.29083  -16.88994 -9.94726  1.000 14.26433  ? 140 PHE A CD1 1 
ATOM   1088 C CD2 . PHE A 1 140 ? 10.52803 -18.82784 -9.32239  1.000 13.22006  ? 140 PHE A CD2 1 
ATOM   1089 C CE1 . PHE A 1 140 ? 9.53044  -16.33077 -8.71100  1.000 13.72531  ? 140 PHE A CE1 1 
ATOM   1090 C CE2 . PHE A 1 140 ? 10.79476 -18.26161 -8.07718  1.000 15.79306  ? 140 PHE A CE2 1 
ATOM   1091 C CZ  . PHE A 1 140 ? 10.28377 -17.01597 -7.76844  1.000 17.47100  ? 140 PHE A CZ  1 
ATOM   1092 N N   . LEU A 1 141 ? 7.76171  -18.19905 -14.39665 1.000 17.27390  ? 141 LEU A N   1 
ATOM   1093 C CA  . LEU A 1 141 ? 7.76836  -18.22560 -15.85193 1.000 23.00738  ? 141 LEU A CA  1 
ATOM   1094 C C   . LEU A 1 141 ? 8.76709  -17.19917 -16.39465 1.000 17.87888  ? 141 LEU A C   1 
ATOM   1095 O O   . LEU A 1 141 ? 9.37307  -16.41032 -15.65137 1.000 17.44201  ? 141 LEU A O   1 
ATOM   1096 C CB  . LEU A 1 141 ? 6.36968  -17.91804 -16.38412 1.000 16.49667  ? 141 LEU A CB  1 
ATOM   1097 C CG  . LEU A 1 141 ? 5.27057  -18.82105 -15.81468 1.000 17.27873  ? 141 LEU A CG  1 
ATOM   1098 C CD1 . LEU A 1 141 ? 3.94170  -18.22875 -16.25148 1.000 18.28374  ? 141 LEU A CD1 1 
ATOM   1099 C CD2 . LEU A 1 141 ? 5.40262  -20.27144 -16.26258 1.000 19.87136  ? 141 LEU A CD2 1 
ATOM   1100 N N   . ASN A 1 142 ? 8.95166  -17.20365 -17.71382 1.000 19.34194  ? 142 ASN A N   1 
ATOM   1101 C CA  . ASN A 1 142 ? 9.79972  -16.17508 -18.29597 1.000 21.03233  ? 142 ASN A CA  1 
ATOM   1102 C C   . ASN A 1 142 ? 9.21346  -14.81994 -17.92516 1.000 17.32684  ? 142 ASN A C   1 
ATOM   1103 O O   . ASN A 1 142 ? 7.98960  -14.61790 -17.96959 1.000 21.15069  ? 142 ASN A O   1 
ATOM   1104 C CB  . ASN A 1 142 ? 9.88023  -16.35248 -19.81811 1.000 23.48029  ? 142 ASN A CB  1 
ATOM   1105 C CG  . ASN A 1 142 ? 10.82902 -17.45847 -20.21892 1.000 26.77464  ? 142 ASN A CG  1 
ATOM   1106 O OD1 . ASN A 1 142 ? 11.61275 -17.95444 -19.39888 1.000 30.46481  ? 142 ASN A OD1 1 
ATOM   1107 N ND2 . ASN A 1 142 ? 10.71920 -17.90836 -21.45637 1.000 38.84617  ? 142 ASN A ND2 1 
ATOM   1108 N N   . GLY A 1 143 ? 10.07364 -13.88638 -17.53078 1.000 17.41814  ? 143 GLY A N   1 
ATOM   1109 C CA  . GLY A 1 143 ? 9.63236  -12.59288 -17.06897 1.000 17.50027  ? 143 GLY A CA  1 
ATOM   1110 C C   . GLY A 1 143 ? 9.65227  -12.43030 -15.56997 1.000 16.86551  ? 143 GLY A C   1 
ATOM   1111 O O   . GLY A 1 143 ? 9.50391  -11.30051 -15.07826 1.000 18.13687  ? 143 GLY A O   1 
ATOM   1112 N N   . SER A 1 144 ? 9.84224  -13.52744 -14.81799 1.000 14.27087  ? 144 SER A N   1 
ATOM   1113 C CA  . SER A 1 144 ? 9.70363  -13.43569 -13.38012 1.000 15.74597  ? 144 SER A CA  1 
ATOM   1114 C C   . SER A 1 144 ? 11.00638 -13.08183 -12.68725 1.000 10.50811  ? 144 SER A C   1 
ATOM   1115 O O   . SER A 1 144 ? 10.98314 -12.76922 -11.49638 1.000 13.61092  ? 144 SER A O   1 
ATOM   1116 C CB  . SER A 1 144 ? 9.19551  -14.76519 -12.82844 1.000 13.33680  ? 144 SER A CB  1 
ATOM   1117 O OG  . SER A 1 144 ? 10.14967 -15.75415 -13.10388 1.000 14.14520  ? 144 SER A OG  1 
ATOM   1118 N N   . ALA A 1 145 ? 12.13649 -13.16033 -13.38476 1.000 11.30236  ? 145 ALA A N   1 
ATOM   1119 C CA  . ALA A 1 145 ? 13.39065 -12.76342 -12.75512 1.000 12.84766  ? 145 ALA A CA  1 
ATOM   1120 C C   . ALA A 1 145 ? 13.29031 -11.37715 -12.11952 1.000 16.22592  ? 145 ALA A C   1 
ATOM   1121 O O   . ALA A 1 145 ? 12.61637 -10.47345 -12.63245 1.000 18.32986  ? 145 ALA A O   1 
ATOM   1122 C CB  . ALA A 1 145 ? 14.52007 -12.80899 -13.79421 1.000 17.84291  ? 145 ALA A CB  1 
ATOM   1123 N N   . GLY A 1 146 ? 13.95087 -11.20077 -10.96910 1.000 13.98621  ? 146 GLY A N   1 
ATOM   1124 C CA  . GLY A 1 146 ? 13.76280 -9.99110  -10.18851 1.000 13.28189  ? 146 GLY A CA  1 
ATOM   1125 C C   . GLY A 1 146 ? 12.67565 -10.03602 -9.13687  1.000 16.06930  ? 146 GLY A C   1 
ATOM   1126 O O   . GLY A 1 146 ? 12.65133 -9.17116  -8.24820  1.000 12.75546  ? 146 GLY A O   1 
ATOM   1127 N N   . SER A 1 147 ? 11.75039 -10.99307 -9.20858  1.000 11.09832  ? 147 SER A N   1 
ATOM   1128 C CA  . SER A 1 147 ? 10.83529 -11.20061 -8.08569  1.000 8.16924   ? 147 SER A CA  1 
ATOM   1129 C C   . SER A 1 147 ? 11.64920 -11.52686 -6.85023  1.000 10.71058  ? 147 SER A C   1 
ATOM   1130 O O   . SER A 1 147 ? 12.70063 -12.15655 -6.95640  1.000 12.82264  ? 147 SER A O   1 
ATOM   1131 C CB  . SER A 1 147 ? 9.87269  -12.36270 -8.37322  1.000 15.90983  ? 147 SER A CB  1 
ATOM   1132 O OG  . SER A 1 147 ? 9.11153  -12.12286 -9.55031  1.000 18.98917  ? 147 SER A OG  1 
ATOM   1133 N N   . VAL A 1 148 ? 11.15952 -11.11937 -5.68019  1.000 11.31721  ? 148 VAL A N   1 
ATOM   1134 C CA  . VAL A 1 148 ? 11.92551 -11.27150 -4.44889  1.000 11.89865  ? 148 VAL A CA  1 
ATOM   1135 C C   . VAL A 1 148 ? 11.22228 -12.17798 -3.45167  1.000 11.48617  ? 148 VAL A C   1 
ATOM   1136 O O   . VAL A 1 148 ? 9.99335  -12.32150 -3.44712  1.000 10.81262  ? 148 VAL A O   1 
ATOM   1137 C CB  . VAL A 1 148 ? 12.23032 -9.90887  -3.79880  1.000 11.20760  ? 148 VAL A CB  1 
ATOM   1138 C CG1 . VAL A 1 148 ? 13.14982 -9.10939  -4.74865  1.000 15.52376  ? 148 VAL A CG1 1 
ATOM   1139 C CG2 . VAL A 1 148 ? 10.92235 -9.13792  -3.43924  1.000 13.77923  ? 148 VAL A CG2 1 
ATOM   1140 N N   . GLY A 1 149 ? 12.03403 -12.79832 -2.58577  1.000 7.84961   ? 149 GLY A N   1 
ATOM   1141 C CA  . GLY A 1 149 ? 11.53926 -13.52523 -1.42622  1.000 10.62865  ? 149 GLY A CA  1 
ATOM   1142 C C   . GLY A 1 149 ? 11.81599 -12.72212 -0.16831  1.000 12.54786  ? 149 GLY A C   1 
ATOM   1143 O O   . GLY A 1 149 ? 12.81968 -11.98987 -0.08764  1.000 15.56230  ? 149 GLY A O   1 
ATOM   1144 N N   . PHE A 1 150 ? 10.93924 -12.87105 0.84098   1.000 9.77247   ? 150 PHE A N   1 
ATOM   1145 C CA  . PHE A 1 150 ? 11.06001 -12.01347 2.01564   1.000 11.40360  ? 150 PHE A CA  1 
ATOM   1146 C C   . PHE A 1 150 ? 10.38847 -12.63271 3.22267   1.000 13.21047  ? 150 PHE A C   1 
ATOM   1147 O O   . PHE A 1 150 ? 9.51536  -13.50320 3.10390   1.000 12.36046  ? 150 PHE A O   1 
ATOM   1148 C CB  . PHE A 1 150 ? 10.44451 -10.61751 1.77198   1.000 12.35970  ? 150 PHE A CB  1 
ATOM   1149 C CG  . PHE A 1 150 ? 8.99295  -10.65870 1.41049   1.000 14.61672  ? 150 PHE A CG  1 
ATOM   1150 C CD1 . PHE A 1 150 ? 8.62278  -10.93490 0.10955   1.000 12.68061  ? 150 PHE A CD1 1 
ATOM   1151 C CD2 . PHE A 1 150 ? 7.99985  -10.43086 2.36078   1.000 15.37366  ? 150 PHE A CD2 1 
ATOM   1152 C CE1 . PHE A 1 150 ? 7.26226  -11.01366 -0.25556  1.000 17.04285  ? 150 PHE A CE1 1 
ATOM   1153 C CE2 . PHE A 1 150 ? 6.65388  -10.48103 2.00644   1.000 18.95753  ? 150 PHE A CE2 1 
ATOM   1154 C CZ  . PHE A 1 150 ? 6.29268  -10.78442 0.70034   1.000 17.43050  ? 150 PHE A CZ  1 
ATOM   1155 N N   . ASN A 1 151 ? 10.78935 -12.13876 4.38166   1.000 14.05250  ? 151 ASN A N   1 
ATOM   1156 C CA  . ASN A 1 151 ? 10.08910 -12.35270 5.63700   1.000 16.23854  ? 151 ASN A CA  1 
ATOM   1157 C C   . ASN A 1 151 ? 9.77263  -10.99692 6.23922   1.000 16.44646  ? 151 ASN A C   1 
ATOM   1158 O O   . ASN A 1 151 ? 10.42703 -9.99405  5.93432   1.000 15.70746  ? 151 ASN A O   1 
ATOM   1159 C CB  . ASN A 1 151 ? 10.91481 -13.18271 6.61155   1.000 13.14801  ? 151 ASN A CB  1 
ATOM   1160 C CG  . ASN A 1 151 ? 10.96342 -14.64939 6.22174   1.000 22.67996  ? 151 ASN A CG  1 
ATOM   1161 O OD1 . ASN A 1 151 ? 10.07104 -15.41939 6.56155   1.000 18.25721  ? 151 ASN A OD1 1 
ATOM   1162 N ND2 . ASN A 1 151 ? 12.01053 -15.04545 5.51297   1.000 12.59494  ? 151 ASN A ND2 1 
ATOM   1163 N N   . ILE A 1 152 ? 8.73796  -10.93879 7.05966   1.000 15.18371  ? 152 ILE A N   1 
ATOM   1164 C CA  . ILE A 1 152 ? 8.39264  -9.68624  7.72063   1.000 17.80312  ? 152 ILE A CA  1 
ATOM   1165 C C   . ILE A 1 152 ? 8.40923  -9.92641  9.21851   1.000 31.21587  ? 152 ILE A C   1 
ATOM   1166 O O   . ILE A 1 152 ? 7.94965  -10.96959 9.69508   1.000 28.74091  ? 152 ILE A O   1 
ATOM   1167 C CB  . ILE A 1 152 ? 7.04994  -9.10178  7.23422   1.000 21.07283  ? 152 ILE A CB  1 
ATOM   1168 C CG1 . ILE A 1 152 ? 7.05941  -9.05863  5.69420   1.000 24.60340  ? 152 ILE A CG1 1 
ATOM   1169 C CG2 . ILE A 1 152 ? 6.84533  -7.70441  7.85744   1.000 20.08619  ? 152 ILE A CG2 1 
ATOM   1170 C CD1 . ILE A 1 152 ? 5.93387  -8.26685  4.98004   1.000 21.88248  ? 152 ILE A CD1 1 
ATOM   1171 N N   . ASP A 1 153 ? 9.02854  -8.99641  9.94318   1.000 22.02985  ? 153 ASP A N   1 
ATOM   1172 C CA  . ASP A 1 153 ? 9.09276  -8.99497  11.40215  1.000 35.19830  ? 153 ASP A CA  1 
ATOM   1173 C C   . ASP A 1 153 ? 8.65536  -7.62561  11.89251  1.000 25.34831  ? 153 ASP A C   1 
ATOM   1174 O O   . ASP A 1 153 ? 9.28819  -6.61674  11.56280  1.000 38.46241  ? 153 ASP A O   1 
ATOM   1175 C CB  . ASP A 1 153 ? 10.49487 -9.31249  11.91354  1.000 26.14210  ? 153 ASP A CB  1 
ATOM   1176 C CG  . ASP A 1 153 ? 10.50224 -9.58425  13.39968  1.000 59.89935  ? 153 ASP A CG  1 
ATOM   1177 O OD1 . ASP A 1 153 ? 9.49027  -10.14399 13.88619  1.000 61.90044  ? 153 ASP A OD1 1 
ATOM   1178 O OD2 . ASP A 1 153 ? 11.51518 -9.26907  14.07310  1.000 61.19305  ? 153 ASP A OD2 1 
ATOM   1179 N N   . TYR A 1 154 ? 7.58565  -7.59447  12.68856  1.000 39.19510  ? 154 TYR A N   1 
ATOM   1180 C CA  . TYR A 1 154 ? 6.87058  -6.35000  12.92806  1.000 33.32548  ? 154 TYR A CA  1 
ATOM   1181 C C   . TYR A 1 154 ? 6.59633  -5.61421  11.62657  1.000 37.06392  ? 154 TYR A C   1 
ATOM   1182 O O   . TYR A 1 154 ? 5.78073  -6.06989  10.81706  1.000 53.65249  ? 154 TYR A O   1 
ATOM   1183 C CB  . TYR A 1 154 ? 7.63533  -5.47121  13.92069  1.000 54.47403  ? 154 TYR A CB  1 
ATOM   1184 C CG  . TYR A 1 154 ? 8.35667  -6.26382  14.99442  1.000 66.95918  ? 154 TYR A CG  1 
ATOM   1185 C CD1 . TYR A 1 154 ? 7.63882  -6.88458  16.02466  1.000 66.53775  ? 154 TYR A CD1 1 
ATOM   1186 C CD2 . TYR A 1 154 ? 9.74430  -6.38324  14.99427  1.000 72.44241  ? 154 TYR A CD2 1 
ATOM   1187 C CE1 . TYR A 1 154 ? 8.28374  -7.60754  17.02189  1.000 71.83693  ? 154 TYR A CE1 1 
ATOM   1188 C CE2 . TYR A 1 154 ? 10.40239 -7.10455  15.99010  1.000 82.30856  ? 154 TYR A CE2 1 
ATOM   1189 C CZ  . TYR A 1 154 ? 9.66657  -7.71442  17.00010  1.000 91.03365  ? 154 TYR A CZ  1 
ATOM   1190 O OH  . TYR A 1 154 ? 10.31708 -8.42985  17.98745  1.000 100.12646 ? 154 TYR A OH  1 
ATOM   1191 N N   . ASP A 1 155 ? 7.25150  -4.47271  11.40805  1.000 26.76978  ? 155 ASP A N   1 
ATOM   1192 C CA  . ASP A 1 155 ? 7.06421  -3.73745  10.16031  1.000 39.70284  ? 155 ASP A CA  1 
ATOM   1193 C C   . ASP A 1 155 ? 8.33018  -3.73193  9.30742   1.000 28.32230  ? 155 ASP A C   1 
ATOM   1194 O O   . ASP A 1 155 ? 8.44116  -2.94007  8.36196   1.000 25.38730  ? 155 ASP A O   1 
ATOM   1195 C CB  . ASP A 1 155 ? 6.59535  -2.30415  10.43328  1.000 29.31300  ? 155 ASP A CB  1 
ATOM   1196 C CG  . ASP A 1 155 ? 5.06736  -2.18298  10.55184  1.000 63.54628  ? 155 ASP A CG  1 
ATOM   1197 O OD1 . ASP A 1 155 ? 4.59007  -1.05539  10.81843  1.000 66.04492  ? 155 ASP A OD1 1 
ATOM   1198 O OD2 . ASP A 1 155 ? 4.34054  -3.18817  10.35165  1.000 56.12596  ? 155 ASP A OD2 1 
ATOM   1199 N N   . CYS A 1 156 ? 9.27422  -4.60691  9.61957   1.000 23.90525  ? 156 CYS A N   1 
ATOM   1200 C CA  . CYS A 1 156 ? 10.55607 -4.64702  8.93277   1.000 21.49814  ? 156 CYS A CA  1 
ATOM   1201 C C   . CYS A 1 156 ? 10.54992 -5.79543  7.93293   1.000 18.58199  ? 156 CYS A C   1 
ATOM   1202 O O   . CYS A 1 156 ? 10.37738 -6.96210  8.31983   1.000 24.07572  ? 156 CYS A O   1 
ATOM   1203 C CB  . CYS A 1 156 ? 11.71060 -4.80590  9.91630   1.000 18.32465  ? 156 CYS A CB  1 
ATOM   1204 S SG  . CYS A 1 156 ? 13.32137 -4.75883  8.97305   1.000 25.87724  ? 156 CYS A SG  1 
ATOM   1205 N N   . VAL A 1 157 ? 10.73695 -5.46806  6.66340   1.000 21.45231  ? 157 VAL A N   1 
ATOM   1206 C CA  . VAL A 1 157 ? 10.79958 -6.47132  5.60618   1.000 17.30718  ? 157 VAL A CA  1 
ATOM   1207 C C   . VAL A 1 157 ? 12.24740 -6.92023  5.46897   1.000 20.28900  ? 157 VAL A C   1 
ATOM   1208 O O   . VAL A 1 157 ? 13.11026 -6.10834  5.13210   1.000 17.23484  ? 157 VAL A O   1 
ATOM   1209 C CB  . VAL A 1 157 ? 10.29411 -5.91250  4.26962   1.000 12.81614  ? 157 VAL A CB  1 
ATOM   1210 C CG1 . VAL A 1 157 ? 10.45525 -6.95927  3.15067   1.000 14.25113  ? 157 VAL A CG1 1 
ATOM   1211 C CG2 . VAL A 1 157 ? 8.82686  -5.39516  4.43263   1.000 14.55355  ? 157 VAL A CG2 1 
ATOM   1212 N N   . SER A 1 158 ? 12.50423 -8.21040  5.67304   1.000 14.81651  ? 158 SER A N   1 
ATOM   1213 C CA  . SER A 1 158 ? 13.83780 -8.77999  5.45530   1.000 11.72825  ? 158 SER A CA  1 
ATOM   1214 C C   . SER A 1 158 ? 13.83656 -9.48533  4.11970   1.000 12.58026  ? 158 SER A C   1 
ATOM   1215 O O   . SER A 1 158 ? 13.26329 -10.57263 3.99033   1.000 12.10592  ? 158 SER A O   1 
ATOM   1216 C CB  . SER A 1 158 ? 14.19365 -9.76965  6.55479   1.000 11.89781  ? 158 SER A CB  1 
ATOM   1217 O OG  . SER A 1 158 ? 14.51704 -9.07266  7.73895   1.000 20.36617  ? 158 SER A OG  1 
ATOM   1218 N N   . PHE A 1 159 ? 14.46870 -8.87487  3.11790   1.000 13.89418  ? 159 PHE A N   1 
ATOM   1219 C CA  . PHE A 1 159 ? 14.54022 -9.47162  1.79649   1.000 11.38621  ? 159 PHE A CA  1 
ATOM   1220 C C   . PHE A 1 159 ? 15.64765 -10.50184 1.84840   1.000 12.44264  ? 159 PHE A C   1 
ATOM   1221 O O   . PHE A 1 159 ? 16.73313 -10.21509 2.36667   1.000 12.14596  ? 159 PHE A O   1 
ATOM   1222 C CB  . PHE A 1 159 ? 14.85221 -8.40214  0.73649   1.000 13.32691  ? 159 PHE A CB  1 
ATOM   1223 C CG  . PHE A 1 159 ? 13.75517 -7.40171  0.53928   1.000 13.74272  ? 159 PHE A CG  1 
ATOM   1224 C CD1 . PHE A 1 159 ? 12.64467 -7.73733  -0.23324  1.000 13.67910  ? 159 PHE A CD1 1 
ATOM   1225 C CD2 . PHE A 1 159 ? 13.84838 -6.12445  1.09489   1.000 12.22295  ? 159 PHE A CD2 1 
ATOM   1226 C CE1 . PHE A 1 159 ? 11.60812 -6.82762  -0.43282  1.000 12.89670  ? 159 PHE A CE1 1 
ATOM   1227 C CE2 . PHE A 1 159 ? 12.82161 -5.19625  0.90441   1.000 14.34336  ? 159 PHE A CE2 1 
ATOM   1228 C CZ  . PHE A 1 159 ? 11.68988 -5.56687  0.14655   1.000 13.51620  ? 159 PHE A CZ  1 
ATOM   1229 N N   . CYS A 1 160 ? 15.37744 -11.68905 1.32852   1.000 10.12324  ? 160 CYS A N   1 
ATOM   1230 C CA  . CYS A 1 160 ? 16.38204 -12.76190 1.34199   1.000 13.39806  ? 160 CYS A CA  1 
ATOM   1231 C C   . CYS A 1 160 ? 16.60852 -13.47581 0.01263   1.000 13.04220  ? 160 CYS A C   1 
ATOM   1232 O O   . CYS A 1 160 ? 17.58914 -14.23987 -0.09425  1.000 10.20409  ? 160 CYS A O   1 
ATOM   1233 C CB  . CYS A 1 160 ? 16.02950 -13.81649 2.39792   1.000 10.25555  ? 160 CYS A CB  1 
ATOM   1234 S SG  . CYS A 1 160 ? 14.44024 -14.61910 2.06238   1.000 12.16644  ? 160 CYS A SG  1 
ATOM   1235 N N   . TYR A 1 161 ? 15.81547 -13.19260 -1.01642  1.000 9.89099   ? 161 TYR A N   1 
ATOM   1236 C CA  . TYR A 1 161 ? 15.97231 -13.88247 -2.28778  1.000 9.15265   ? 161 TYR A CA  1 
ATOM   1237 C C   . TYR A 1 161 ? 15.59069 -12.94033 -3.42437  1.000 10.93350  ? 161 TYR A C   1 
ATOM   1238 O O   . TYR A 1 161 ? 14.65110 -12.15995 -3.29986  1.000 12.80402  ? 161 TYR A O   1 
ATOM   1239 C CB  . TYR A 1 161 ? 15.11035 -15.15112 -2.32639  1.000 12.01560  ? 161 TYR A CB  1 
ATOM   1240 C CG  . TYR A 1 161 ? 15.16019 -15.93861 -3.61846  1.000 10.05643  ? 161 TYR A CG  1 
ATOM   1241 C CD1 . TYR A 1 161 ? 16.19444 -16.81462 -3.88888  1.000 11.11296  ? 161 TYR A CD1 1 
ATOM   1242 C CD2 . TYR A 1 161 ? 14.12061 -15.84539 -4.56175  1.000 8.37708   ? 161 TYR A CD2 1 
ATOM   1243 C CE1 . TYR A 1 161 ? 16.20488 -17.55574 -5.03487  1.000 10.97969  ? 161 TYR A CE1 1 
ATOM   1244 C CE2 . TYR A 1 161 ? 14.14299 -16.56439 -5.71129  1.000 8.43811   ? 161 TYR A CE2 1 
ATOM   1245 C CZ  . TYR A 1 161 ? 15.19956 -17.43890 -5.95087  1.000 12.38612  ? 161 TYR A CZ  1 
ATOM   1246 O OH  . TYR A 1 161 ? 15.30320 -18.19712 -7.10078  1.000 11.79880  ? 161 TYR A OH  1 
ATOM   1247 N N   . MET A 1 162 ? 16.36016 -12.99156 -4.49478  1.000 8.31009   ? 162 MET A N   1 
ATOM   1248 C CA  . MET A 1 162 ? 16.01142 -12.36797 -5.78200  1.000 10.75362  ? 162 MET A CA  1 
ATOM   1249 C C   . MET A 1 162 ? 16.08029 -13.45432 -6.83618  1.000 11.92995  ? 162 MET A C   1 
ATOM   1250 O O   . MET A 1 162 ? 17.09563 -14.14680 -6.94671  1.000 8.50252   ? 162 MET A O   1 
ATOM   1251 C CB  . MET A 1 162 ? 16.96738 -11.25579 -6.18898  1.000 10.98679  ? 162 MET A CB  1 
ATOM   1252 C CG  . MET A 1 162 ? 16.52191 -10.63607 -7.54354  1.000 13.15394  ? 162 MET A CG  1 
ATOM   1253 S SD  . MET A 1 162 ? 17.08549 -8.93055  -7.77738  1.000 21.47595  ? 162 MET A SD  1 
ATOM   1254 C CE  . MET A 1 162 ? 15.65147 -7.99508  -7.23132  1.000 21.56515  ? 162 MET A CE  1 
ATOM   1255 N N   . HIS A 1 163 ? 14.99642 -13.62814 -7.61351  1.000 10.55778  ? 163 HIS A N   1 
ATOM   1256 C CA  . HIS A 1 163 ? 14.95680 -14.75444 -8.52422  1.000 10.73066  ? 163 HIS A CA  1 
ATOM   1257 C C   . HIS A 1 163 ? 15.74676 -14.48238 -9.79969  1.000 13.70677  ? 163 HIS A C   1 
ATOM   1258 O O   . HIS A 1 163 ? 15.65659 -13.38790 -10.34537 1.000 13.35869  ? 163 HIS A O   1 
ATOM   1259 C CB  . HIS A 1 163 ? 13.49898 -15.05976 -8.88656  1.000 10.41575  ? 163 HIS A CB  1 
ATOM   1260 C CG  . HIS A 1 163 ? 13.38293 -16.19706 -9.82158  1.000 12.30590  ? 163 HIS A CG  1 
ATOM   1261 N ND1 . HIS A 1 163 ? 13.96224 -17.41817 -9.56769  1.000 9.24456   ? 163 HIS A ND1 1 
ATOM   1262 C CD2 . HIS A 1 163 ? 12.86391 -16.27892 -11.06760 1.000 11.55403  ? 163 HIS A CD2 1 
ATOM   1263 C CE1 . HIS A 1 163 ? 13.78806 -18.21501 -10.60475 1.000 15.06063  ? 163 HIS A CE1 1 
ATOM   1264 N NE2 . HIS A 1 163 ? 13.09624 -17.55527 -11.52288 1.000 10.01950  ? 163 HIS A NE2 1 
ATOM   1265 N N   . HIS A 1 164 ? 16.51932 -15.48855 -10.27247 1.000 10.95433  ? 164 HIS A N   1 
ATOM   1266 C CA  . HIS A 1 164 ? 17.28929 -15.33456 -11.51338 1.000 10.97550  ? 164 HIS A CA  1 
ATOM   1267 C C   . HIS A 1 164 ? 16.90980 -16.32075 -12.60479 1.000 14.93400  ? 164 HIS A C   1 
ATOM   1268 O O   . HIS A 1 164 ? 16.82222 -15.91797 -13.76758 1.000 14.13330  ? 164 HIS A O   1 
ATOM   1269 C CB  . HIS A 1 164 ? 18.80152 -15.47898 -11.26212 1.000 11.46226  ? 164 HIS A CB  1 
ATOM   1270 C CG  . HIS A 1 164 ? 19.41115 -14.30999 -10.57308 1.000 11.82869  ? 164 HIS A CG  1 
ATOM   1271 N ND1 . HIS A 1 164 ? 20.46497 -13.57624 -11.10459 1.000 11.65368  ? 164 HIS A ND1 1 
ATOM   1272 C CD2 . HIS A 1 164 ? 19.10443 -13.73509 -9.38961  1.000 10.80476  ? 164 HIS A CD2 1 
ATOM   1273 C CE1 . HIS A 1 164 ? 20.77769 -12.60853 -10.26005 1.000 11.62426  ? 164 HIS A CE1 1 
ATOM   1274 N NE2 . HIS A 1 164 ? 19.97511 -12.69206 -9.20618  1.000 11.52553  ? 164 HIS A NE2 1 
ATOM   1275 N N   . MET A 1 165 ? 16.77955 -17.61326 -12.30010 1.000 12.87973  ? 165 MET A N   1 
ATOM   1276 C CA  . MET A 1 165 ? 16.81185 -18.58778 -13.38027 1.000 10.94141  ? 165 MET A CA  1 
ATOM   1277 C C   . MET A 1 165 ? 16.15563 -19.87996 -12.94794 1.000 16.20578  ? 165 MET A C   1 
ATOM   1278 O O   . MET A 1 165 ? 15.91770 -20.12042 -11.76105 1.000 13.83546  ? 165 MET A O   1 
ATOM   1279 C CB  . MET A 1 165 ? 18.24936 -18.91816 -13.80878 1.000 14.39669  ? 165 MET A CB  1 
ATOM   1280 C CG  . MET A 1 165 ? 19.12968 -19.21703 -12.61057 1.000 11.70064  ? 165 MET A CG  1 
ATOM   1281 S SD  . MET A 1 165 ? 20.85269 -19.03791 -13.10709 1.000 20.14475  ? 165 MET A SD  1 
ATOM   1282 C CE  . MET A 1 165 ? 21.61775 -20.31487 -12.16720 1.000 16.56689  ? 165 MET A CE  1 
ATOM   1283 N N   . GLU A 1 166 ? 15.92992 -20.73501 -13.93519 1.000 14.17606  ? 166 GLU A N   1 
ATOM   1284 C CA  . GLU A 1 166 ? 15.31160 -22.02978 -13.72802 1.000 13.75073  ? 166 GLU A CA  1 
ATOM   1285 C C   . GLU A 1 166 ? 16.26075 -23.10277 -14.24778 1.000 19.19453  ? 166 GLU A C   1 
ATOM   1286 O O   . GLU A 1 166 ? 16.78104 -22.99725 -15.36355 1.000 19.25021  ? 166 GLU A O   1 
ATOM   1287 C CB  . GLU A 1 166 ? 13.94224 -22.10179 -14.41953 1.000 14.35910  ? 166 GLU A CB  1 
ATOM   1288 C CG  . GLU A 1 166 ? 13.28630 -23.45072 -14.25977 1.000 17.43330  ? 166 GLU A CG  1 
ATOM   1289 C CD  . GLU A 1 166 ? 11.85572 -23.49592 -14.76415 1.000 21.49951  ? 166 GLU A CD  1 
ATOM   1290 O OE1 . GLU A 1 166 ? 10.98843 -22.70140 -14.31418 1.000 16.09063  ? 166 GLU A OE1 1 
ATOM   1291 O OE2 . GLU A 1 166 ? 11.61075 -24.33881 -15.65076 1.000 22.84972  ? 166 GLU A OE2 1 
ATOM   1292 N N   . LEU A 1 167 ? 16.49348 -24.11077 -13.42765 1.000 15.47776  ? 167 LEU A N   1 
ATOM   1293 C CA  . LEU A 1 167 ? 17.35791 -25.22236 -13.75800 1.000 15.84351  ? 167 LEU A CA  1 
ATOM   1294 C C   . LEU A 1 167 ? 16.56973 -26.24381 -14.58150 1.000 18.63696  ? 167 LEU A C   1 
ATOM   1295 O O   . LEU A 1 167 ? 15.33749 -26.19769 -14.62997 1.000 20.55679  ? 167 LEU A O   1 
ATOM   1296 C CB  . LEU A 1 167 ? 17.93205 -25.84766 -12.47256 1.000 16.77032  ? 167 LEU A CB  1 
ATOM   1297 C CG  . LEU A 1 167 ? 18.59651 -24.83679 -11.51500 1.000 20.74206  ? 167 LEU A CG  1 
ATOM   1298 C CD1 . LEU A 1 167 ? 19.07569 -25.47410 -10.20750 1.000 21.94041  ? 167 LEU A CD1 1 
ATOM   1299 C CD2 . LEU A 1 167 ? 19.75852 -24.12591 -12.17199 1.000 31.36140  ? 167 LEU A CD2 1 
ATOM   1300 N N   . PRO A 1 168 ? 17.26673 -27.17443 -15.24829 1.000 30.47111  ? 168 PRO A N   1 
ATOM   1301 C CA  . PRO A 1 168 ? 16.56998 -28.13808 -16.11763 1.000 25.11527  ? 168 PRO A CA  1 
ATOM   1302 C C   . PRO A 1 168 ? 15.51606 -28.98235 -15.41940 1.000 32.03354  ? 168 PRO A C   1 
ATOM   1303 O O   . PRO A 1 168 ? 14.57002 -29.42750 -16.08065 1.000 31.73631  ? 168 PRO A O   1 
ATOM   1304 C CB  . PRO A 1 168 ? 17.72485 -29.01200 -16.64232 1.000 25.27287  ? 168 PRO A CB  1 
ATOM   1305 C CG  . PRO A 1 168 ? 18.90218 -28.16503 -16.55922 1.000 30.53817  ? 168 PRO A CG  1 
ATOM   1306 C CD  . PRO A 1 168 ? 18.73488 -27.30232 -15.36710 1.000 27.37060  ? 168 PRO A CD  1 
ATOM   1307 N N   . THR A 1 169 ? 15.64444 -29.23731 -14.11878 1.000 24.32503  ? 169 THR A N   1 
ATOM   1308 C CA  . THR A 1 169 ? 14.64891 -30.00610 -13.38546 1.000 25.12372  ? 169 THR A CA  1 
ATOM   1309 C C   . THR A 1 169 ? 13.44025 -29.16349 -13.01809 1.000 21.55491  ? 169 THR A C   1 
ATOM   1310 O O   . THR A 1 169 ? 12.49833 -29.67738 -12.41953 1.000 26.33173  ? 169 THR A O   1 
ATOM   1311 C CB  . THR A 1 169 ? 15.26889 -30.60454 -12.11815 1.000 30.00285  ? 169 THR A CB  1 
ATOM   1312 O OG1 . THR A 1 169 ? 15.91183 -29.56603 -11.37650 1.000 25.55463  ? 169 THR A OG1 1 
ATOM   1313 C CG2 . THR A 1 169 ? 16.34781 -31.63675 -12.48693 1.000 21.49126  ? 169 THR A CG2 1 
ATOM   1314 N N   . GLY A 1 170 ? 13.42587 -27.88635 -13.36646 1.000 18.70100  ? 170 GLY A N   1 
ATOM   1315 C CA  . GLY A 1 170 ? 12.24004 -27.09398 -13.09596 1.000 24.58428  ? 170 GLY A CA  1 
ATOM   1316 C C   . GLY A 1 170 ? 12.22307 -26.44995 -11.73339 1.000 24.65238  ? 170 GLY A C   1 
ATOM   1317 O O   . GLY A 1 170 ? 11.19326 -25.88961 -11.33957 1.000 22.79297  ? 170 GLY A O   1 
ATOM   1318 N N   . VAL A 1 171 ? 13.32392 -26.51537 -10.99899 1.000 20.91078  ? 171 VAL A N   1 
ATOM   1319 C CA  . VAL A 1 171 ? 13.45004 -25.81866 -9.73915  1.000 11.83268  ? 171 VAL A CA  1 
ATOM   1320 C C   . VAL A 1 171 ? 14.28370 -24.56456 -9.99243  1.000 12.16989  ? 171 VAL A C   1 
ATOM   1321 O O   . VAL A 1 171 ? 14.80690 -24.35144 -11.08068 1.000 17.72067  ? 171 VAL A O   1 
ATOM   1322 C CB  . VAL A 1 171 ? 14.10400 -26.69341 -8.66616  1.000 12.44842  ? 171 VAL A CB  1 
ATOM   1323 C CG1 . VAL A 1 171 ? 13.23341 -27.94181 -8.35188  1.000 15.33951  ? 171 VAL A CG1 1 
ATOM   1324 C CG2 . VAL A 1 171 ? 15.52719 -27.04712 -9.04786  1.000 14.96547  ? 171 VAL A CG2 1 
ATOM   1325 N N   . HIS A 1 172 ? 14.42266 -23.73387 -8.97874  1.000 13.00302  ? 172 HIS A N   1 
ATOM   1326 C CA  . HIS A 1 172 ? 14.78487 -22.33628 -9.22286  1.000 11.56322  ? 172 HIS A CA  1 
ATOM   1327 C C   . HIS A 1 172 ? 16.00925 -21.91957 -8.43313  1.000 13.09845  ? 172 HIS A C   1 
ATOM   1328 O O   . HIS A 1 172 ? 16.31707 -22.49661 -7.39547  1.000 13.06608  ? 172 HIS A O   1 
ATOM   1329 C CB  . HIS A 1 172 ? 13.58362 -21.44470 -8.94381  1.000 10.20160  ? 172 HIS A CB  1 
ATOM   1330 C CG  . HIS A 1 172 ? 12.43295 -21.75986 -9.84106  1.000 11.12889  ? 172 HIS A CG  1 
ATOM   1331 N ND1 . HIS A 1 172 ? 11.29621 -22.44787 -9.43550  1.000 14.21869  ? 172 HIS A ND1 1 
ATOM   1332 C CD2 . HIS A 1 172 ? 12.28712 -21.53537 -11.16731 1.000 12.54243  ? 172 HIS A CD2 1 
ATOM   1333 C CE1 . HIS A 1 172 ? 10.48294 -22.58072 -10.47696 1.000 14.77493  ? 172 HIS A CE1 1 
ATOM   1334 N NE2 . HIS A 1 172 ? 11.08499 -22.07012 -11.54688 1.000 15.28094  ? 172 HIS A NE2 1 
ATOM   1335 N N   . ALA A 1 173 ? 16.75367 -20.95717 -9.00318  1.000 12.02891  ? 173 ALA A N   1 
ATOM   1336 C CA  . ALA A 1 173 ? 18.04167 -20.54095 -8.47383  1.000 11.40540  ? 173 ALA A CA  1 
ATOM   1337 C C   . ALA A 1 173 ? 18.09885 -19.02504 -8.50755  1.000 14.25991  ? 173 ALA A C   1 
ATOM   1338 O O   . ALA A 1 173 ? 17.56697 -18.38716 -9.43294  1.000 12.91956  ? 173 ALA A O   1 
ATOM   1339 C CB  . ALA A 1 173 ? 19.24444 -21.17961 -9.26441  1.000 12.92293  ? 173 ALA A CB  1 
ATOM   1340 N N   . GLY A 1 174 ? 18.70294 -18.44586 -7.47246  1.000 9.37205   ? 174 GLY A N   1 
ATOM   1341 C CA  . GLY A 1 174 ? 18.78272 -17.00359 -7.40938  1.000 12.24318  ? 174 GLY A CA  1 
ATOM   1342 C C   . GLY A 1 174 ? 19.77991 -16.59457 -6.35159  1.000 9.96640   ? 174 GLY A C   1 
ATOM   1343 O O   . GLY A 1 174 ? 20.53729 -17.42514 -5.84730  1.000 11.21448  ? 174 GLY A O   1 
ATOM   1344 N N   . THR A 1 175 ? 19.74084 -15.31319 -6.00143  1.000 10.62214  ? 175 THR A N   1 
ATOM   1345 C CA  . THR A 1 175 ? 20.74389 -14.69838 -5.13882  1.000 11.45928  ? 175 THR A CA  1 
ATOM   1346 C C   . THR A 1 175 ? 20.10730 -14.10033 -3.89870  1.000 13.22269  ? 175 THR A C   1 
ATOM   1347 O O   . THR A 1 175 ? 18.88077 -13.95069 -3.79521  1.000 9.54363   ? 175 THR A O   1 
ATOM   1348 C CB  . THR A 1 175 ? 21.51809 -13.59921 -5.89008  1.000 8.81230   ? 175 THR A CB  1 
ATOM   1349 O OG1 . THR A 1 175 ? 20.62213 -12.51740 -6.20527  1.000 10.87797  ? 175 THR A OG1 1 
ATOM   1350 C CG2 . THR A 1 175 ? 22.10464 -14.17427 -7.15649  1.000 9.79815   ? 175 THR A CG2 1 
ATOM   1351 N N   . ASP A 1 176 ? 20.97278 -13.72317 -2.95937  1.000 11.84724  ? 176 ASP A N   1 
ATOM   1352 C CA  . ASP A 1 176 ? 20.56085 -12.78520 -1.92502  1.000 11.60112  ? 176 ASP A CA  1 
ATOM   1353 C C   . ASP A 1 176 ? 20.46241 -11.39042 -2.56624  1.000 12.11254  ? 176 ASP A C   1 
ATOM   1354 O O   . ASP A 1 176 ? 20.74341 -11.20453 -3.75749  1.000 11.17698  ? 176 ASP A O   1 
ATOM   1355 C CB  . ASP A 1 176 ? 21.52343 -12.89143 -0.71764  1.000 10.08031  ? 176 ASP A CB  1 
ATOM   1356 C CG  . ASP A 1 176 ? 22.95991 -12.53687 -1.04891  1.000 13.98852  ? 176 ASP A CG  1 
ATOM   1357 O OD1 . ASP A 1 176 ? 23.18907 -11.69417 -1.92909  1.000 12.10941  ? 176 ASP A OD1 1 
ATOM   1358 O OD2 . ASP A 1 176 ? 23.88089 -13.07435 -0.38271  1.000 10.63478  ? 176 ASP A OD2 1 
ATOM   1359 N N   . LEU A 1 177 ? 20.06008 -10.39623 -1.79710  1.000 10.32814  ? 177 LEU A N   1 
ATOM   1360 C CA  . LEU A 1 177 ? 19.84944 -9.09968  -2.42859  1.000 12.04226  ? 177 LEU A CA  1 
ATOM   1361 C C   . LEU A 1 177 ? 21.16075 -8.34926  -2.59912  1.000 14.09979  ? 177 LEU A C   1 
ATOM   1362 O O   . LEU A 1 177 ? 21.16422 -7.24301  -3.14736  1.000 14.33514  ? 177 LEU A O   1 
ATOM   1363 C CB  . LEU A 1 177 ? 18.87135 -8.25320  -1.61777  1.000 8.99986   ? 177 LEU A CB  1 
ATOM   1364 C CG  . LEU A 1 177 ? 17.39543 -8.29936  -2.02902  1.000 11.53977  ? 177 LEU A CG  1 
ATOM   1365 C CD1 . LEU A 1 177 ? 17.18038 -7.68774  -3.41115  1.000 18.44453  ? 177 LEU A CD1 1 
ATOM   1366 C CD2 . LEU A 1 177 ? 16.86254 -9.81385  -1.91799  1.000 12.92393  ? 177 LEU A CD2 1 
ATOM   1367 N N   . GLU A 1 178 ? 22.26215 -8.91396  -2.11490  1.000 11.71277  ? 178 GLU A N   1 
ATOM   1368 C CA  . GLU A 1 178 ? 23.58407 -8.39190  -2.44978  1.000 11.39624  ? 178 GLU A CA  1 
ATOM   1369 C C   . GLU A 1 178 ? 24.20407 -9.15229  -3.62963  1.000 13.72962  ? 178 GLU A C   1 
ATOM   1370 O O   . GLU A 1 178 ? 25.35417 -8.90940  -3.99397  1.000 16.07714  ? 178 GLU A O   1 
ATOM   1371 C CB  . GLU A 1 178 ? 24.48918 -8.37150  -1.18388  1.000 15.03435  ? 178 GLU A CB  1 
ATOM   1372 C CG  . GLU A 1 178 ? 23.85074 -7.46747  -0.10927  1.000 21.12793  ? 178 GLU A CG  1 
ATOM   1373 C CD  . GLU A 1 178 ? 24.73522 -7.08689  1.06187   1.000 38.96053  ? 178 GLU A CD  1 
ATOM   1374 O OE1 . GLU A 1 178 ? 25.70529 -7.80432  1.34461   1.000 23.63062  ? 178 GLU A OE1 1 
ATOM   1375 O OE2 . GLU A 1 178 ? 24.43305 -6.06260  1.71058   1.000 38.44158  ? 178 GLU A OE2 1 
ATOM   1376 N N   . GLY A 1 179 ? 23.42020 -9.98750  -4.31741  1.000 16.70166  ? 179 GLY A N   1 
ATOM   1377 C CA  . GLY A 1 179 ? 23.86452 -10.59897 -5.55702  1.000 9.63342   ? 179 GLY A CA  1 
ATOM   1378 C C   . GLY A 1 179 ? 24.66172 -11.88336 -5.44012  1.000 12.51599  ? 179 GLY A C   1 
ATOM   1379 O O   . GLY A 1 179 ? 25.16232 -12.37669 -6.45791  1.000 11.91206  ? 179 GLY A O   1 
ATOM   1380 N N   . ASN A 1 180 ? 24.80848 -12.45958 -4.25240  1.000 11.03380  ? 180 ASN A N   1 
ATOM   1381 C CA  . ASN A 1 180 ? 25.53500 -13.72481 -4.16265  1.000 9.98270   ? 180 ASN A CA  1 
ATOM   1382 C C   . ASN A 1 180 ? 24.53756 -14.86719 -4.35745  1.000 10.33864  ? 180 ASN A C   1 
ATOM   1383 O O   . ASN A 1 180 ? 23.55344 -14.95863 -3.61451  1.000 11.95557  ? 180 ASN A O   1 
ATOM   1384 C CB  . ASN A 1 180 ? 26.19966 -13.86984 -2.80300  1.000 8.77929   ? 180 ASN A CB  1 
ATOM   1385 C CG  . ASN A 1 180 ? 27.11571 -12.68302 -2.47217  1.000 15.01146  ? 180 ASN A CG  1 
ATOM   1386 O OD1 . ASN A 1 180 ? 28.14424 -12.47482 -3.13818  1.000 14.18187  ? 180 ASN A OD1 1 
ATOM   1387 N ND2 . ASN A 1 180 ? 26.66801 -11.84365 -1.51023  1.000 12.86250  ? 180 ASN A ND2 1 
ATOM   1388 N N   . PHE A 1 181 ? 24.81172 -15.76158 -5.30547  1.000 9.78041   ? 181 PHE A N   1 
ATOM   1389 C CA  . PHE A 1 181 ? 23.93105 -16.91836 -5.48126  1.000 10.01124  ? 181 PHE A CA  1 
ATOM   1390 C C   . PHE A 1 181 ? 23.86277 -17.77631 -4.22037  1.000 8.99186   ? 181 PHE A C   1 
ATOM   1391 O O   . PHE A 1 181 ? 24.82361 -17.89652 -3.47144  1.000 10.58845  ? 181 PHE A O   1 
ATOM   1392 C CB  . PHE A 1 181 ? 24.41351 -17.77338 -6.64454  1.000 9.46815   ? 181 PHE A CB  1 
ATOM   1393 C CG  . PHE A 1 181 ? 23.73696 -17.41796 -7.94775  1.000 12.38073  ? 181 PHE A CG  1 
ATOM   1394 C CD1 . PHE A 1 181 ? 22.51523 -17.97198 -8.29160  1.000 11.54726  ? 181 PHE A CD1 1 
ATOM   1395 C CD2 . PHE A 1 181 ? 24.32331 -16.48673 -8.78545  1.000 12.25841  ? 181 PHE A CD2 1 
ATOM   1396 C CE1 . PHE A 1 181 ? 21.83021 -17.60326 -9.45920  1.000 11.68225  ? 181 PHE A CE1 1 
ATOM   1397 C CE2 . PHE A 1 181 ? 23.68398 -16.09957 -9.99085  1.000 12.83514  ? 181 PHE A CE2 1 
ATOM   1398 C CZ  . PHE A 1 181 ? 22.42667 -16.66941 -10.33182 1.000 14.79941  ? 181 PHE A CZ  1 
ATOM   1399 N N   . TYR A 1 182 ? 22.68647 -18.35866 -3.97048  1.000 7.39069   ? 182 TYR A N   1 
ATOM   1400 C CA  . TYR A 1 182 ? 22.60474 -19.52296 -3.10752  1.000 6.98307   ? 182 TYR A CA  1 
ATOM   1401 C C   . TYR A 1 182 ? 23.07573 -20.73973 -3.86944  1.000 12.27002  ? 182 TYR A C   1 
ATOM   1402 O O   . TYR A 1 182 ? 22.67793 -20.92157 -5.00815  1.000 11.87581  ? 182 TYR A O   1 
ATOM   1403 C CB  . TYR A 1 182 ? 21.15630 -19.69240 -2.66785  1.000 8.83993   ? 182 TYR A CB  1 
ATOM   1404 C CG  . TYR A 1 182 ? 20.72354 -18.59937 -1.70220  1.000 9.71223   ? 182 TYR A CG  1 
ATOM   1405 C CD1 . TYR A 1 182 ? 21.09409 -18.66735 -0.33338  1.000 9.75278   ? 182 TYR A CD1 1 
ATOM   1406 C CD2 . TYR A 1 182 ? 20.00800 -17.46598 -2.14082  1.000 8.31476   ? 182 TYR A CD2 1 
ATOM   1407 C CE1 . TYR A 1 182 ? 20.70401 -17.68046 0.58735   1.000 9.05547   ? 182 TYR A CE1 1 
ATOM   1408 C CE2 . TYR A 1 182 ? 19.59102 -16.47703 -1.22950  1.000 8.77186   ? 182 TYR A CE2 1 
ATOM   1409 C CZ  . TYR A 1 182 ? 19.93374 -16.60249 0.12477   1.000 9.06352   ? 182 TYR A CZ  1 
ATOM   1410 O OH  . TYR A 1 182 ? 19.53240 -15.63753 1.00061   1.000 11.32058  ? 182 TYR A OH  1 
ATOM   1411 N N   . GLY A 1 183 ? 23.92944 -21.56584 -3.25910  1.000 9.13529   ? 183 GLY A N   1 
ATOM   1412 C CA  . GLY A 1 183 ? 24.41495 -22.74866 -3.96168  1.000 10.16963  ? 183 GLY A CA  1 
ATOM   1413 C C   . GLY A 1 183 ? 25.55088 -22.43438 -4.90587  1.000 10.33477  ? 183 GLY A C   1 
ATOM   1414 O O   . GLY A 1 183 ? 26.10427 -21.33826 -4.91214  1.000 11.36562  ? 183 GLY A O   1 
ATOM   1415 N N   . PRO A 1 184 ? 25.92292 -23.43714 -5.70247  1.000 11.62177  ? 184 PRO A N   1 
ATOM   1416 C CA  . PRO A 1 184 ? 27.08864 -23.35568 -6.60475  1.000 12.14391  ? 184 PRO A CA  1 
ATOM   1417 C C   . PRO A 1 184 ? 26.79668 -22.72957 -7.95946  1.000 20.37163  ? 184 PRO A C   1 
ATOM   1418 O O   . PRO A 1 184 ? 27.64781 -22.80738 -8.84806  1.000 15.93140  ? 184 PRO A O   1 
ATOM   1419 C CB  . PRO A 1 184 ? 27.44921 -24.83327 -6.79347  1.000 15.38512  ? 184 PRO A CB  1 
ATOM   1420 C CG  . PRO A 1 184 ? 26.06084 -25.53471 -6.75863  1.000 11.14582  ? 184 PRO A CG  1 
ATOM   1421 C CD  . PRO A 1 184 ? 25.22136 -24.72746 -5.76123  1.000 15.67857  ? 184 PRO A CD  1 
ATOM   1422 N N   . PHE A 1 185 ? 25.62657 -22.13735 -8.13328  1.000 11.43269  ? 185 PHE A N   1 
ATOM   1423 C CA  . PHE A 1 185 ? 25.15278 -21.72088 -9.44232  1.000 13.90717  ? 185 PHE A CA  1 
ATOM   1424 C C   . PHE A 1 185 ? 25.78132 -20.41323 -9.89339  1.000 17.94632  ? 185 PHE A C   1 
ATOM   1425 O O   . PHE A 1 185 ? 26.25058 -19.60455 -9.08410  1.000 16.23800  ? 185 PHE A O   1 
ATOM   1426 C CB  . PHE A 1 185 ? 23.63040 -21.63780 -9.40539  1.000 15.53791  ? 185 PHE A CB  1 
ATOM   1427 C CG  . PHE A 1 185 ? 23.01378 -22.87481 -8.86137  1.000 12.59851  ? 185 PHE A CG  1 
ATOM   1428 C CD1 . PHE A 1 185 ? 23.10981 -24.07123 -9.56626  1.000 10.67493  ? 185 PHE A CD1 1 
ATOM   1429 C CD2 . PHE A 1 185 ? 22.36211 -22.88080 -7.63098  1.000 14.54242  ? 185 PHE A CD2 1 
ATOM   1430 C CE1 . PHE A 1 185 ? 22.57995 -25.25657 -9.03865  1.000 21.06775  ? 185 PHE A CE1 1 
ATOM   1431 C CE2 . PHE A 1 185 ? 21.85228 -24.04724 -7.10881  1.000 9.35488   ? 185 PHE A CE2 1 
ATOM   1432 C CZ  . PHE A 1 185 ? 21.93387 -25.24642 -7.80898  1.000 16.52693  ? 185 PHE A CZ  1 
ATOM   1433 N N   . VAL A 1 186 ? 25.87507 -20.26486 -11.22764 1.000 16.61894  ? 186 VAL A N   1 
ATOM   1434 C CA  . VAL A 1 186 ? 26.40273 -19.06832 -11.85547 1.000 12.40091  ? 186 VAL A CA  1 
ATOM   1435 C C   . VAL A 1 186 ? 25.41337 -18.57971 -12.90967 1.000 18.39836  ? 186 VAL A C   1 
ATOM   1436 O O   . VAL A 1 186 ? 24.65080 -19.37722 -13.47443 1.000 19.47262  ? 186 VAL A O   1 
ATOM   1437 C CB  . VAL A 1 186 ? 27.78937 -19.36637 -12.47121 1.000 13.62845  ? 186 VAL A CB  1 
ATOM   1438 C CG1 . VAL A 1 186 ? 28.73766 -19.63078 -11.34661 1.000 19.12957  ? 186 VAL A CG1 1 
ATOM   1439 C CG2 . VAL A 1 186 ? 27.73048 -20.56102 -13.41927 1.000 21.34432  ? 186 VAL A CG2 1 
ATOM   1440 N N   . ASP A 1 187 ? 25.37518 -17.25625 -13.12515 1.000 12.87421  ? 187 ASP A N   1 
ATOM   1441 C CA  . ASP A 1 187 ? 24.48366 -16.67720 -14.14891 1.000 15.78807  ? 187 ASP A CA  1 
ATOM   1442 C C   . ASP A 1 187 ? 25.12441 -16.76848 -15.53449 1.000 22.26094  ? 187 ASP A C   1 
ATOM   1443 O O   . ASP A 1 187 ? 25.37860 -15.76215 -16.21629 1.000 20.11775  ? 187 ASP A O   1 
ATOM   1444 C CB  . ASP A 1 187 ? 24.03921 -15.23278 -13.87610 1.000 13.95791  ? 187 ASP A CB  1 
ATOM   1445 C CG  . ASP A 1 187 ? 25.15450 -14.29258 -13.40261 1.000 14.57916  ? 187 ASP A CG  1 
ATOM   1446 O OD1 . ASP A 1 187 ? 26.33747 -14.68807 -13.36979 1.000 16.51708  ? 187 ASP A OD1 1 
ATOM   1447 O OD2 . ASP A 1 187 ? 24.82572 -13.12669 -13.08836 1.000 15.41275  ? 187 ASP A OD2 1 
ATOM   1448 N N   . ARG A 1 188 ? 25.35908 -18.00998 -15.94096 1.000 23.97259  ? 188 ARG A N   1 
ATOM   1449 C CA  . ARG A 1 188 ? 25.79792 -18.33716 -17.29090 1.000 33.15321  ? 188 ARG A CA  1 
ATOM   1450 C C   . ARG A 1 188 ? 24.92852 -19.45431 -17.81708 1.000 47.04257  ? 188 ARG A C   1 
ATOM   1451 O O   . ARG A 1 188 ? 24.45506 -20.31449 -17.06700 1.000 36.08643  ? 188 ARG A O   1 
ATOM   1452 C CB  . ARG A 1 188 ? 27.27201 -18.81714 -17.42716 1.000 36.37502  ? 188 ARG A CB  1 
ATOM   1453 C CG  . ARG A 1 188 ? 28.30163 -18.23968 -16.51901 1.000 38.24682  ? 188 ARG A CG  1 
ATOM   1454 C CD  . ARG A 1 188 ? 29.52608 -19.13918 -16.48093 1.000 43.60395  ? 188 ARG A CD  1 
ATOM   1455 N NE  . ARG A 1 188 ? 29.81198 -19.71689 -17.79277 1.000 51.33667  ? 188 ARG A NE  1 
ATOM   1456 C CZ  . ARG A 1 188 ? 30.54508 -20.80968 -17.99163 1.000 57.50598  ? 188 ARG A CZ  1 
ATOM   1457 N NH1 . ARG A 1 188 ? 31.17454 -21.41716 -16.99267 1.000 31.23626  ? 188 ARG A NH1 1 
ATOM   1458 N NH2 . ARG A 1 188 ? 30.66930 -21.29353 -19.22621 1.000 49.29198  ? 188 ARG A NH2 1 
ATOM   1459 N N   . GLN A 1 189 ? 24.70529 -19.41651 -19.11754 1.000 58.52065  ? 189 GLN A N   1 
ATOM   1460 C CA  . GLN A 1 189 ? 24.18153 -20.57901 -19.80872 1.000 55.30679  ? 189 GLN A CA  1 
ATOM   1461 C C   . GLN A 1 189 ? 25.26594 -21.64459 -19.81014 1.000 64.47049  ? 189 GLN A C   1 
ATOM   1462 O O   . GLN A 1 189 ? 26.23755 -21.57233 -20.56950 1.000 53.09275  ? 189 GLN A O   1 
ATOM   1463 C CB  . GLN A 1 189 ? 23.76426 -20.23112 -21.22818 1.000 62.50699  ? 189 GLN A CB  1 
ATOM   1464 C CG  . GLN A 1 189 ? 23.12467 -21.41179 -21.83330 1.000 58.27576  ? 189 GLN A CG  1 
ATOM   1465 C CD  . GLN A 1 189 ? 21.94718 -21.77950 -20.98973 1.000 56.07575  ? 189 GLN A CD  1 
ATOM   1466 O OE1 . GLN A 1 189 ? 21.77938 -22.93836 -20.61252 1.000 65.94424  ? 189 GLN A OE1 1 
ATOM   1467 N NE2 . GLN A 1 189 ? 21.13934 -20.77439 -20.63463 1.000 53.77684  ? 189 GLN A NE2 1 
ATOM   1468 N N   . THR A 1 190 ? 25.12430 -22.62848 -18.93817 1.000 51.19366  ? 190 THR A N   1 
ATOM   1469 C CA  . THR A 1 190 ? 26.04624 -23.74531 -18.93740 1.000 40.08868  ? 190 THR A CA  1 
ATOM   1470 C C   . THR A 1 190 ? 25.28430 -24.92462 -18.36178 1.000 47.92438  ? 190 THR A C   1 
ATOM   1471 O O   . THR A 1 190 ? 24.14487 -24.78616 -17.90331 1.000 44.05890  ? 190 THR A O   1 
ATOM   1472 C CB  . THR A 1 190 ? 27.34599 -23.39277 -18.18178 1.000 47.07272  ? 190 THR A CB  1 
ATOM   1473 O OG1 . THR A 1 190 ? 28.34109 -24.41671 -18.35817 1.000 56.23380  ? 190 THR A OG1 1 
ATOM   1474 C CG2 . THR A 1 190 ? 27.09802 -23.16596 -16.70273 1.000 48.25034  ? 190 THR A CG2 1 
ATOM   1475 N N   . ALA A 1 191 ? 25.88239 -26.10396 -18.46836 1.000 49.52399  ? 191 ALA A N   1 
ATOM   1476 C CA  . ALA A 1 191 ? 25.36152 -27.24511 -17.73583 1.000 43.10863  ? 191 ALA A CA  1 
ATOM   1477 C C   . ALA A 1 191 ? 25.55706 -26.96105 -16.25852 1.000 31.58169  ? 191 ALA A C   1 
ATOM   1478 O O   . ALA A 1 191 ? 26.67876 -26.70534 -15.80835 1.000 31.44642  ? 191 ALA A O   1 
ATOM   1479 C CB  . ALA A 1 191 ? 26.06686 -28.53949 -18.14198 1.000 33.51761  ? 191 ALA A CB  1 
ATOM   1480 N N   . GLN A 1 192 ? 24.45696 -26.91525 -15.52835 1.000 28.87020  ? 192 GLN A N   1 
ATOM   1481 C CA  . GLN A 1 192 ? 24.46116 -26.77563 -14.08608 1.000 29.74577  ? 192 GLN A CA  1 
ATOM   1482 C C   . GLN A 1 192 ? 23.31846 -27.62525 -13.57863 1.000 34.22503  ? 192 GLN A C   1 
ATOM   1483 O O   . GLN A 1 192 ? 22.25918 -27.70025 -14.21725 1.000 34.10834  ? 192 GLN A O   1 
ATOM   1484 C CB  . GLN A 1 192 ? 24.23606 -25.32687 -13.62971 1.000 25.22385  ? 192 GLN A CB  1 
ATOM   1485 C CG  . GLN A 1 192 ? 25.25108 -24.34647 -14.10016 1.000 30.97148  ? 192 GLN A CG  1 
ATOM   1486 C CD  . GLN A 1 192 ? 24.90844 -22.93954 -13.69354 1.000 28.82193  ? 192 GLN A CD  1 
ATOM   1487 O OE1 . GLN A 1 192 ? 24.92734 -22.59949 -12.50747 1.000 25.14384  ? 192 GLN A OE1 1 
ATOM   1488 N NE2 . GLN A 1 192 ? 24.58448 -22.10672 -14.66797 1.000 17.99644  ? 192 GLN A NE2 1 
ATOM   1489 N N   . ALA A 1 193 ? 23.53985 -28.25747 -12.43653 1.000 26.81185  ? 193 ALA A N   1 
ATOM   1490 C CA  . ALA A 1 193 ? 22.55015 -29.16578 -11.87935 1.000 41.34408  ? 193 ALA A CA  1 
ATOM   1491 C C   . ALA A 1 193 ? 22.64318 -29.12357 -10.36352 1.000 28.32357  ? 193 ALA A C   1 
ATOM   1492 O O   . ALA A 1 193 ? 23.74845 -29.13239 -9.79662  1.000 35.08512  ? 193 ALA A O   1 
ATOM   1493 C CB  . ALA A 1 193 ? 22.75280 -30.60231 -12.38759 1.000 41.31536  ? 193 ALA A CB  1 
ATOM   1494 N N   . ALA A 1 194 ? 21.47144 -29.06445 -9.73354  1.000 48.72276  ? 194 ALA A N   1 
ATOM   1495 C CA  . ALA A 1 194 ? 21.36874 -29.12288 -8.28331  1.000 34.44318  ? 194 ALA A CA  1 
ATOM   1496 C C   . ALA A 1 194 ? 21.99837 -30.40010 -7.74302  1.000 35.82968  ? 194 ALA A C   1 
ATOM   1497 O O   . ALA A 1 194 ? 21.87102 -31.47818 -8.33673  1.000 38.15143  ? 194 ALA A O   1 
ATOM   1498 C CB  . ALA A 1 194 ? 19.90589 -29.05795 -7.87181  1.000 39.65213  ? 194 ALA A CB  1 
ATOM   1499 N N   . GLY A 1 195 ? 22.69481 -30.26443 -6.61857  1.000 31.35842  ? 195 GLY A N   1 
ATOM   1500 C CA  . GLY A 1 195 ? 23.06739 -31.42609 -5.84229  1.000 43.95843  ? 195 GLY A CA  1 
ATOM   1501 C C   . GLY A 1 195 ? 21.84257 -32.17098 -5.36032  1.000 26.64703  ? 195 GLY A C   1 
ATOM   1502 O O   . GLY A 1 195 ? 20.71951 -31.66026 -5.38807  1.000 28.61742  ? 195 GLY A O   1 
ATOM   1503 N N   . THR A 1 196 ? 22.04055 -33.41659 -4.94835  1.000 33.62767  ? 196 THR A N   1 
ATOM   1504 C CA  . THR A 1 196 ? 20.88603 -34.19711 -4.52845  1.000 34.05977  ? 196 THR A CA  1 
ATOM   1505 C C   . THR A 1 196 ? 20.26782 -33.56744 -3.28152  1.000 22.56425  ? 196 THR A C   1 
ATOM   1506 O O   . THR A 1 196 ? 20.96579 -33.11662 -2.37181  1.000 38.04610  ? 196 THR A O   1 
ATOM   1507 C CB  . THR A 1 196 ? 21.27965 -35.64455 -4.26109  1.000 36.50712  ? 196 THR A CB  1 
ATOM   1508 O OG1 . THR A 1 196 ? 22.12784 -35.67734 -3.11526  1.000 50.43302  ? 196 THR A OG1 1 
ATOM   1509 C CG2 . THR A 1 196 ? 22.03837 -36.22944 -5.46764  1.000 26.08906  ? 196 THR A CG2 1 
ATOM   1510 N N   . ASP A 1 197 ? 18.95734 -33.50308 -3.25885  1.000 21.27384  ? 197 ASP A N   1 
ATOM   1511 C CA  . ASP A 1 197 ? 18.32892 -32.82433 -2.14765  1.000 24.89081  ? 197 ASP A CA  1 
ATOM   1512 C C   . ASP A 1 197 ? 18.00327 -33.79950 -1.04057  1.000 27.68898  ? 197 ASP A C   1 
ATOM   1513 O O   . ASP A 1 197 ? 17.96377 -35.01379 -1.23736  1.000 39.01124  ? 197 ASP A O   1 
ATOM   1514 C CB  . ASP A 1 197 ? 17.05913 -32.13287 -2.57787  1.000 14.93457  ? 197 ASP A CB  1 
ATOM   1515 C CG  . ASP A 1 197 ? 16.68679 -30.94257 -1.66599  1.000 18.58054  ? 197 ASP A CG  1 
ATOM   1516 O OD1 . ASP A 1 197 ? 17.55584 -30.39086 -0.92889  1.000 17.09364  ? 197 ASP A OD1 1 
ATOM   1517 O OD2 . ASP A 1 197 ? 15.50579 -30.56899 -1.71415  1.000 17.05576  ? 197 ASP A OD2 1 
ATOM   1518 N N   . THR A 1 198 ? 17.73822 -33.22892 0.12570   1.000 26.91665  ? 198 THR A N   1 
ATOM   1519 C CA  . THR A 1 198 ? 17.41037 -33.93838 1.35606   1.000 13.41563  ? 198 THR A CA  1 
ATOM   1520 C C   . THR A 1 198 ? 16.20686 -33.28010 2.00986   1.000 19.64338  ? 198 THR A C   1 
ATOM   1521 O O   . THR A 1 198 ? 15.84715 -32.13482 1.68915   1.000 14.87698  ? 198 THR A O   1 
ATOM   1522 C CB  . THR A 1 198 ? 18.56947 -33.92002 2.30815   1.000 22.98974  ? 198 THR A CB  1 
ATOM   1523 O OG1 . THR A 1 198 ? 18.91846 -32.56401 2.56507   1.000 19.46470  ? 198 THR A OG1 1 
ATOM   1524 C CG2 . THR A 1 198 ? 19.76728 -34.60580 1.65227   1.000 31.24340  ? 198 THR A CG2 1 
ATOM   1525 N N   . THR A 1 199 ? 15.57557 -34.02661 2.92476   1.000 16.26510  ? 199 THR A N   1 
ATOM   1526 C CA  . THR A 1 199 ? 14.39594 -33.51851 3.58589   1.000 14.45643  ? 199 THR A CA  1 
ATOM   1527 C C   . THR A 1 199 ? 14.84221 -32.77547 4.83353   1.000 16.08347  ? 199 THR A C   1 
ATOM   1528 O O   . THR A 1 199 ? 15.77781 -33.19507 5.51290   1.000 15.99790  ? 199 THR A O   1 
ATOM   1529 C CB  . THR A 1 199 ? 13.40334 -34.64514 3.90904   1.000 14.13215  ? 199 THR A CB  1 
ATOM   1530 O OG1 . THR A 1 199 ? 12.99659 -35.30852 2.68634   1.000 16.95578  ? 199 THR A OG1 1 
ATOM   1531 C CG2 . THR A 1 199 ? 12.15176 -34.08052 4.54504   1.000 13.14960  ? 199 THR A CG2 1 
ATOM   1532 N N   . ILE A 1 200 ? 14.21893 -31.61943 5.09089   1.000 12.60086  ? 200 ILE A N   1 
ATOM   1533 C CA  . ILE A 1 200 ? 14.55850 -30.80308 6.23428   1.000 9.80512   ? 200 ILE A CA  1 
ATOM   1534 C C   . ILE A 1 200 ? 13.93270 -31.33069 7.52406   1.000 13.99440  ? 200 ILE A C   1 
ATOM   1535 O O   . ILE A 1 200 ? 12.82610 -30.93494 7.89968   1.000 13.11194  ? 200 ILE A O   1 
ATOM   1536 C CB  . ILE A 1 200 ? 14.12671 -29.34542 6.02033   1.000 14.36898  ? 200 ILE A CB  1 
ATOM   1537 C CG1 . ILE A 1 200 ? 14.63985 -28.83135 4.66069   1.000 10.08649  ? 200 ILE A CG1 1 
ATOM   1538 C CG2 . ILE A 1 200 ? 14.61518 -28.47367 7.17049   1.000 11.28114  ? 200 ILE A CG2 1 
ATOM   1539 C CD1 . ILE A 1 200 ? 13.79507 -27.68172 4.08283   1.000 9.05038   ? 200 ILE A CD1 1 
ATOM   1540 N N   . THR A 1 201 ? 14.69053 -32.15108 8.24039   1.000 17.54490  ? 201 THR A N   1 
ATOM   1541 C CA  . THR A 1 201 ? 14.18648 -32.87387 9.41479   1.000 15.27267  ? 201 THR A CA  1 
ATOM   1542 C C   . THR A 1 201 ? 13.54362 -31.98293 10.47802  1.000 16.41270  ? 201 THR A C   1 
ATOM   1543 O O   . THR A 1 201 ? 12.45359 -32.29533 10.98638  1.000 16.67476  ? 201 THR A O   1 
ATOM   1544 C CB  . THR A 1 201 ? 15.36734 -33.63203 10.02923  1.000 13.21716  ? 201 THR A CB  1 
ATOM   1545 O OG1 . THR A 1 201 ? 15.94592 -34.44906 9.02020   1.000 13.82221  ? 201 THR A OG1 1 
ATOM   1546 C CG2 . THR A 1 201 ? 14.83309 -34.51857 11.17849  1.000 14.04531  ? 201 THR A CG2 1 
ATOM   1547 N N   . VAL A 1 202 ? 14.24032 -30.92722 10.89820  1.000 13.59816  ? 202 VAL A N   1 
ATOM   1548 C CA  . VAL A 1 202 ? 13.74610 -30.05681 11.95454  1.000 13.89641  ? 202 VAL A CA  1 
ATOM   1549 C C   . VAL A 1 202 ? 12.41187 -29.44642 11.55207  1.000 13.26608  ? 202 VAL A C   1 
ATOM   1550 O O   . VAL A 1 202 ? 11.55763 -29.23384 12.40903  1.000 13.46259  ? 202 VAL A O   1 
ATOM   1551 C CB  . VAL A 1 202 ? 14.76397 -28.95019 12.32284  1.000 15.45853  ? 202 VAL A CB  1 
ATOM   1552 C CG1 . VAL A 1 202 ? 14.96166 -27.98700 11.10977  1.000 12.35162  ? 202 VAL A CG1 1 
ATOM   1553 C CG2 . VAL A 1 202 ? 14.29856 -28.14674 13.52068  1.000 16.39493  ? 202 VAL A CG2 1 
ATOM   1554 N N   . ASN A 1 203 ? 12.19109 -29.19922 10.24952  1.000 13.23792  ? 203 ASN A N   1 
ATOM   1555 C CA  . ASN A 1 203 ? 10.90676 -28.66883 9.79978   1.000 11.48118  ? 203 ASN A CA  1 
ATOM   1556 C C   . ASN A 1 203 ? 9.80470  -29.72323 9.86376   1.000 14.82932  ? 203 ASN A C   1 
ATOM   1557 O O   . ASN A 1 203 ? 8.64944  -29.40871 10.19175  1.000 12.73507  ? 203 ASN A O   1 
ATOM   1558 C CB  . ASN A 1 203 ? 11.00976 -28.14935 8.38257   1.000 10.39440  ? 203 ASN A CB  1 
ATOM   1559 C CG  . ASN A 1 203 ? 11.76383 -26.84339 8.30120   1.000 10.50048  ? 203 ASN A CG  1 
ATOM   1560 O OD1 . ASN A 1 203 ? 12.29314 -26.31121 9.30171   1.000 11.46525  ? 203 ASN A OD1 1 
ATOM   1561 N ND2 . ASN A 1 203 ? 11.84382 -26.31605 7.07433   1.000 12.10362  ? 203 ASN A ND2 1 
ATOM   1562 N N   . VAL A 1 204 ? 10.12702 -30.96584 9.49128   1.000 13.00498  ? 204 VAL A N   1 
ATOM   1563 C CA  . VAL A 1 204 ? 9.13322  -32.03240 9.58208   1.000 11.00634  ? 204 VAL A CA  1 
ATOM   1564 C C   . VAL A 1 204 ? 8.66270  -32.15581 11.01915  1.000 12.73957  ? 204 VAL A C   1 
ATOM   1565 O O   . VAL A 1 204 ? 7.45896  -32.28830 11.28897  1.000 14.71936  ? 204 VAL A O   1 
ATOM   1566 C CB  . VAL A 1 204 ? 9.70578  -33.37189 9.08186   1.000 11.06923  ? 204 VAL A CB  1 
ATOM   1567 C CG1 . VAL A 1 204 ? 8.69604  -34.45841 9.33446   1.000 14.40291  ? 204 VAL A CG1 1 
ATOM   1568 C CG2 . VAL A 1 204 ? 9.99263  -33.32364 7.57037   1.000 15.53654  ? 204 VAL A CG2 1 
ATOM   1569 N N   . LEU A 1 205 ? 9.62112  -32.14828 11.96038  1.000 12.30352  ? 205 LEU A N   1 
ATOM   1570 C CA  . LEU A 1 205 ? 9.28147  -32.21998 13.37892  1.000 14.49470  ? 205 LEU A CA  1 
ATOM   1571 C C   . LEU A 1 205 ? 8.39845  -31.05247 13.80160  1.000 12.22642  ? 205 LEU A C   1 
ATOM   1572 O O   . LEU A 1 205 ? 7.41319  -31.25260 14.53074  1.000 16.06021  ? 205 LEU A O   1 
ATOM   1573 C CB  . LEU A 1 205 ? 10.55400 -32.26489 14.24100  1.000 13.82878  ? 205 LEU A CB  1 
ATOM   1574 C CG  . LEU A 1 205 ? 11.37584 -33.54778 14.16792  1.000 19.10819  ? 205 LEU A CG  1 
ATOM   1575 C CD1 . LEU A 1 205 ? 12.69991 -33.24787 14.82477  1.000 15.25438  ? 205 LEU A CD1 1 
ATOM   1576 C CD2 . LEU A 1 205 ? 10.65678 -34.73521 14.89131  1.000 12.33373  ? 205 LEU A CD2 1 
ATOM   1577 N N   . ALA A 1 206 ? 8.71889  -29.82652 13.35718  1.000 12.90709  ? 206 ALA A N   1 
ATOM   1578 C CA  . ALA A 1 206 ? 7.88619  -28.68099 13.70941  1.000 13.74220  ? 206 ALA A CA  1 
ATOM   1579 C C   . ALA A 1 206 ? 6.44718  -28.87588 13.24522  1.000 10.66014  ? 206 ALA A C   1 
ATOM   1580 O O   . ALA A 1 206 ? 5.50987  -28.53849 13.95711  1.000 14.17310  ? 206 ALA A O   1 
ATOM   1581 C CB  . ALA A 1 206 ? 8.47123  -27.40244 13.09685  1.000 10.20992  ? 206 ALA A CB  1 
ATOM   1582 N N   . TRP A 1 207 ? 6.27337  -29.39764 12.04221  1.000 11.68075  ? 207 TRP A N   1 
ATOM   1583 C CA  . TRP A 1 207 ? 4.95197  -29.61666 11.45597  1.000 9.84056   ? 207 TRP A CA  1 
ATOM   1584 C C   . TRP A 1 207 ? 4.20604  -30.73979 12.17377  1.000 11.86168  ? 207 TRP A C   1 
ATOM   1585 O O   . TRP A 1 207 ? 2.98173  -30.65483 12.38158  1.000 12.71427  ? 207 TRP A O   1 
ATOM   1586 C CB  . TRP A 1 207 ? 5.16182  -29.90718 9.98606   1.000 10.71095  ? 207 TRP A CB  1 
ATOM   1587 C CG  . TRP A 1 207 ? 3.99640  -30.42115 9.19483   1.000 10.32337  ? 207 TRP A CG  1 
ATOM   1588 C CD1 . TRP A 1 207 ? 2.98676  -29.69826 8.65250   1.000 14.88673  ? 207 TRP A CD1 1 
ATOM   1589 C CD2 . TRP A 1 207 ? 3.75400  -31.78339 8.85675   1.000 11.58684  ? 207 TRP A CD2 1 
ATOM   1590 N NE1 . TRP A 1 207 ? 2.13247  -30.52042 7.96719   1.000 16.04095  ? 207 TRP A NE1 1 
ATOM   1591 C CE2 . TRP A 1 207 ? 2.58531  -31.81207 8.07042   1.000 12.95980  ? 207 TRP A CE2 1 
ATOM   1592 C CE3 . TRP A 1 207 ? 4.45996  -32.96132 9.06725   1.000 14.97054  ? 207 TRP A CE3 1 
ATOM   1593 C CZ2 . TRP A 1 207 ? 2.07347  -32.97969 7.53131   1.000 15.54665  ? 207 TRP A CZ2 1 
ATOM   1594 C CZ3 . TRP A 1 207 ? 3.91975  -34.16181 8.52768   1.000 19.36581  ? 207 TRP A CZ3 1 
ATOM   1595 C CH2 . TRP A 1 207 ? 2.75107  -34.14476 7.77783   1.000 17.71902  ? 207 TRP A CH2 1 
ATOM   1596 N N   . LEU A 1 208 ? 4.93771  -31.75106 12.64035  1.000 11.15470  ? 208 LEU A N   1 
ATOM   1597 C CA  . LEU A 1 208 ? 4.26926  -32.72334 13.52217  1.000 8.39047   ? 208 LEU A CA  1 
ATOM   1598 C C   . LEU A 1 208 ? 3.80776  -32.06473 14.81587  1.000 20.83394  ? 208 LEU A C   1 
ATOM   1599 O O   . LEU A 1 208 ? 2.75209  -32.42895 15.34583  1.000 15.73637  ? 208 LEU A O   1 
ATOM   1600 C CB  . LEU A 1 208 ? 5.20215  -33.90897 13.82912  1.000 11.12635  ? 208 LEU A CB  1 
ATOM   1601 C CG  . LEU A 1 208 ? 5.52048  -34.83977 12.62998  1.000 12.01108  ? 208 LEU A CG  1 
ATOM   1602 C CD1 . LEU A 1 208 ? 6.56500  -35.85301 13.07363  1.000 17.42036  ? 208 LEU A CD1 1 
ATOM   1603 C CD2 . LEU A 1 208 ? 4.29312  -35.57774 12.04160  1.000 14.77874  ? 208 LEU A CD2 1 
ATOM   1604 N N   . TYR A 1 209 ? 4.57769  -31.10393 15.35621  1.000 14.65395  ? 209 TYR A N   1 
ATOM   1605 C CA  . TYR A 1 209 ? 4.07989  -30.35994 16.51603  1.000 14.14580  ? 209 TYR A CA  1 
ATOM   1606 C C   . TYR A 1 209 ? 2.85988  -29.53628 16.15205  1.000 18.77370  ? 209 TYR A C   1 
ATOM   1607 O O   . TYR A 1 209 ? 1.91971  -29.39452 16.96496  1.000 15.86601  ? 209 TYR A O   1 
ATOM   1608 C CB  . TYR A 1 209 ? 5.14940  -29.42910 17.09922  1.000 10.75907  ? 209 TYR A CB  1 
ATOM   1609 C CG  . TYR A 1 209 ? 6.11723  -30.15465 17.98689  1.000 18.05231  ? 209 TYR A CG  1 
ATOM   1610 C CD1 . TYR A 1 209 ? 5.72087  -30.59383 19.26620  1.000 16.07329  ? 209 TYR A CD1 1 
ATOM   1611 C CD2 . TYR A 1 209 ? 7.40069  -30.39984 17.55295  1.000 18.21077  ? 209 TYR A CD2 1 
ATOM   1612 C CE1 . TYR A 1 209 ? 6.60421  -31.30199 20.10190  1.000 17.32013  ? 209 TYR A CE1 1 
ATOM   1613 C CE2 . TYR A 1 209 ? 8.29992  -31.11208 18.36353  1.000 18.24804  ? 209 TYR A CE2 1 
ATOM   1614 C CZ  . TYR A 1 209 ? 7.88872  -31.54167 19.62574  1.000 21.24425  ? 209 TYR A CZ  1 
ATOM   1615 O OH  . TYR A 1 209 ? 8.78373  -32.22152 20.42220  1.000 21.85388  ? 209 TYR A OH  1 
ATOM   1616 N N   . ALA A 1 210 ? 2.87290  -28.91765 14.95237  1.000 13.76913  ? 210 ALA A N   1 
ATOM   1617 C CA  . ALA A 1 210 ? 1.69034  -28.18096 14.53756  1.000 13.69920  ? 210 ALA A CA  1 
ATOM   1618 C C   . ALA A 1 210 ? 0.46622  -29.09282 14.51017  1.000 14.48765  ? 210 ALA A C   1 
ATOM   1619 O O   . ALA A 1 210 ? -0.64201 -28.66233 14.84878  1.000 16.14560  ? 210 ALA A O   1 
ATOM   1620 C CB  . ALA A 1 210 ? 1.89793  -27.55701 13.16971  1.000 13.90225  ? 210 ALA A CB  1 
ATOM   1621 N N   . ALA A 1 211 ? 0.64806  -30.33837 14.06388  1.000 12.94177  ? 211 ALA A N   1 
ATOM   1622 C CA  . ALA A 1 211 ? -0.47554 -31.26590 13.97672  1.000 17.81674  ? 211 ALA A CA  1 
ATOM   1623 C C   . ALA A 1 211 ? -1.02733 -31.57585 15.36456  1.000 19.10913  ? 211 ALA A C   1 
ATOM   1624 O O   . ALA A 1 211 ? -2.24789 -31.59113 15.56447  1.000 18.27645  ? 211 ALA A O   1 
ATOM   1625 C CB  . ALA A 1 211 ? -0.03065 -32.54084 13.25393  1.000 14.59177  ? 211 ALA A CB  1 
ATOM   1626 N N   . VAL A 1 212 ? -0.13722 -31.81199 16.33580  1.000 17.76342  ? 212 VAL A N   1 
ATOM   1627 C CA  . VAL A 1 212 ? -0.55794 -32.02307 17.72417  1.000 17.40239  ? 212 VAL A CA  1 
ATOM   1628 C C   . VAL A 1 212 ? -1.30400 -30.81149 18.26484  1.000 23.09515  ? 212 VAL A C   1 
ATOM   1629 O O   . VAL A 1 212 ? -2.36019 -30.94490 18.91371  1.000 21.36453  ? 212 VAL A O   1 
ATOM   1630 C CB  . VAL A 1 212 ? 0.66300  -32.39012 18.59906  1.000 18.07067  ? 212 VAL A CB  1 
ATOM   1631 C CG1 . VAL A 1 212 ? 0.27027  -32.38993 20.08631  1.000 16.02597  ? 212 VAL A CG1 1 
ATOM   1632 C CG2 . VAL A 1 212 ? 1.18282  -33.76834 18.16987  1.000 17.26087  ? 212 VAL A CG2 1 
ATOM   1633 N N   . ILE A 1 213 ? -0.78938 -29.61342 18.00460  1.000 16.00289  ? 213 ILE A N   1 
ATOM   1634 C CA  . ILE A 1 213 ? -1.45122 -28.40527 18.48861  1.000 23.82298  ? 213 ILE A CA  1 
ATOM   1635 C C   . ILE A 1 213 ? -2.85499 -28.32728 17.93702  1.000 21.83805  ? 213 ILE A C   1 
ATOM   1636 O O   . ILE A 1 213 ? -3.78381 -27.87094 18.62161  1.000 25.33677  ? 213 ILE A O   1 
ATOM   1637 C CB  . ILE A 1 213 ? -0.61671 -27.16627 18.11741  1.000 14.72631  ? 213 ILE A CB  1 
ATOM   1638 C CG1 . ILE A 1 213 ? 0.68906  -27.17663 18.91330  1.000 14.37685  ? 213 ILE A CG1 1 
ATOM   1639 C CG2 . ILE A 1 213 ? -1.36667 -25.85052 18.36717  1.000 19.67801  ? 213 ILE A CG2 1 
ATOM   1640 C CD1 . ILE A 1 213 ? 1.69502  -26.16437 18.43633  1.000 17.48213  ? 213 ILE A CD1 1 
ATOM   1641 N N   . ASN A 1 214 ? -3.04720 -28.79428 16.71783  1.000 15.21494  ? 214 ASN A N   1 
ATOM   1642 C CA  . ASN A 1 214 ? -4.35911 -28.74407 16.08216  1.000 24.16022  ? 214 ASN A CA  1 
ATOM   1643 C C   . ASN A 1 214 ? -5.21292 -29.97534 16.33852  1.000 29.53604  ? 214 ASN A C   1 
ATOM   1644 O O   . ASN A 1 214 ? -6.25282 -30.14320 15.68512  1.000 34.21931  ? 214 ASN A O   1 
ATOM   1645 C CB  . ASN A 1 214 ? -4.24785 -28.52477 14.57436  1.000 19.64254  ? 214 ASN A CB  1 
ATOM   1646 C CG  . ASN A 1 214 ? -4.06400 -27.09032 14.22915  1.000 37.85221  ? 214 ASN A CG  1 
ATOM   1647 O OD1 . ASN A 1 214 ? -4.90423 -26.51669 13.53680  1.000 42.27422  ? 214 ASN A OD1 1 
ATOM   1648 N ND2 . ASN A 1 214 ? -2.95867 -26.49656 14.66790  1.000 35.32015  ? 214 ASN A ND2 1 
ATOM   1649 N N   . GLY A 1 215 ? -4.79674 -30.84123 17.24397  1.000 18.45018  ? 215 GLY A N   1 
ATOM   1650 C CA  . GLY A 1 215 ? -5.66295 -31.89652 17.73643  1.000 29.22628  ? 215 GLY A CA  1 
ATOM   1651 C C   . GLY A 1 215 ? -5.45275 -33.25572 17.12064  1.000 38.28008  ? 215 GLY A C   1 
ATOM   1652 O O   . GLY A 1 215 ? -6.31383 -34.12366 17.27026  1.000 39.88663  ? 215 GLY A O   1 
ATOM   1653 N N   . ASP A 1 216 ? -4.33466 -33.47765 16.45557  1.000 31.76366  ? 216 ASP A N   1 
ATOM   1654 C CA  . ASP A 1 216 ? -4.05599 -34.72117 15.74795  1.000 28.12322  ? 216 ASP A CA  1 
ATOM   1655 C C   . ASP A 1 216 ? -2.90549 -35.44949 16.45062  1.000 35.62173  ? 216 ASP A C   1 
ATOM   1656 O O   . ASP A 1 216 ? -1.76306 -34.98252 16.39789  1.000 31.74388  ? 216 ASP A O   1 
ATOM   1657 C CB  . ASP A 1 216 ? -3.68230 -34.40031 14.31001  1.000 30.27635  ? 216 ASP A CB  1 
ATOM   1658 C CG  . ASP A 1 216 ? -4.17821 -35.41426 13.35040  1.000 47.48666  ? 216 ASP A CG  1 
ATOM   1659 O OD1 . ASP A 1 216 ? -4.26910 -35.08620 12.14000  1.000 52.67401  ? 216 ASP A OD1 1 
ATOM   1660 O OD2 . ASP A 1 216 ? -4.49034 -36.52795 13.82478  1.000 52.36428  ? 216 ASP A OD2 1 
ATOM   1661 N N   . ARG A 1 217 ? -3.18384 -36.59975 17.07725  1.000 30.36493  ? 217 ARG A N   1 
ATOM   1662 C CA  . ARG A 1 217 ? -2.15345 -37.32888 17.82064  1.000 20.58921  ? 217 ARG A CA  1 
ATOM   1663 C C   . ARG A 1 217 ? -1.92636 -38.76266 17.33240  1.000 16.14845  ? 217 ARG A C   1 
ATOM   1664 O O   . ARG A 1 217 ? -1.17331 -39.50050 17.99109  1.000 23.98704  ? 217 ARG A O   1 
ATOM   1665 C CB  . ARG A 1 217 ? -2.46486 -37.37153 19.32681  1.000 27.60969  ? 217 ARG A CB  1 
ATOM   1666 C CG  . ARG A 1 217 ? -2.37580 -36.04488 20.08672  1.000 35.46649  ? 217 ARG A CG  1 
ATOM   1667 C CD  . ARG A 1 217 ? -2.93014 -36.17218 21.53639  1.000 20.23696  ? 217 ARG A CD  1 
ATOM   1668 N NE  . ARG A 1 217 ? -2.00088 -36.90463 22.38548  1.000 28.97456  ? 217 ARG A NE  1 
ATOM   1669 C CZ  . ARG A 1 217 ? -1.03077 -36.37591 23.12660  1.000 23.94417  ? 217 ARG A CZ  1 
ATOM   1670 N NH1 . ARG A 1 217 ? -0.84038 -35.06640 23.20204  1.000 34.52890  ? 217 ARG A NH1 1 
ATOM   1671 N NH2 . ARG A 1 217 ? -0.23636 -37.18710 23.82824  1.000 39.87565  ? 217 ARG A NH2 1 
ATOM   1672 N N   . TRP A 1 218 ? -2.49462 -39.16656 16.18345  1.000 19.13155  ? 218 TRP A N   1 
ATOM   1673 C CA  . TRP A 1 218 ? -2.56372 -40.59129 15.84749  1.000 20.99295  ? 218 TRP A CA  1 
ATOM   1674 C C   . TRP A 1 218 ? -1.19390 -41.18771 15.63715  1.000 20.35269  ? 218 TRP A C   1 
ATOM   1675 O O   . TRP A 1 218 ? -1.02241 -42.40552 15.78109  1.000 27.81135  ? 218 TRP A O   1 
ATOM   1676 C CB  . TRP A 1 218 ? -3.38848 -40.86135 14.59392  1.000 22.22831  ? 218 TRP A CB  1 
ATOM   1677 C CG  . TRP A 1 218 ? -2.83618 -40.34823 13.22875  1.000 26.57124  ? 218 TRP A CG  1 
ATOM   1678 C CD1 . TRP A 1 218 ? -3.23729 -39.21769 12.56871  1.000 25.10024  ? 218 TRP A CD1 1 
ATOM   1679 C CD2 . TRP A 1 218 ? -1.82939 -40.95872 12.38836  1.000 21.52758  ? 218 TRP A CD2 1 
ATOM   1680 N NE1 . TRP A 1 218 ? -2.55597 -39.08422 11.38040  1.000 23.44222  ? 218 TRP A NE1 1 
ATOM   1681 C CE2 . TRP A 1 218 ? -1.68543 -40.13367 11.24137  1.000 26.04403  ? 218 TRP A CE2 1 
ATOM   1682 C CE3 . TRP A 1 218 ? -1.03168 -42.11094 12.48859  1.000 19.22215  ? 218 TRP A CE3 1 
ATOM   1683 C CZ2 . TRP A 1 218 ? -0.78680 -40.42980 10.20924  1.000 20.57128  ? 218 TRP A CZ2 1 
ATOM   1684 C CZ3 . TRP A 1 218 ? -0.13670 -42.39943 11.45818  1.000 27.20891  ? 218 TRP A CZ3 1 
ATOM   1685 C CH2 . TRP A 1 218 ? -0.02189 -41.55957 10.33536  1.000 28.84097  ? 218 TRP A CH2 1 
ATOM   1686 N N   . PHE A 1 219 ? -0.22629 -40.35680 15.24880  1.000 19.35765  ? 219 PHE A N   1 
ATOM   1687 C CA  . PHE A 1 219 ? 1.12572  -40.79272 14.93710  1.000 23.21628  ? 219 PHE A CA  1 
ATOM   1688 C C   . PHE A 1 219 ? 2.03971  -40.82484 16.15661  1.000 21.10797  ? 219 PHE A C   1 
ATOM   1689 O O   . PHE A 1 219 ? 3.17645  -41.27941 16.03717  1.000 22.86253  ? 219 PHE A O   1 
ATOM   1690 C CB  . PHE A 1 219 ? 1.73504  -39.85889 13.85572  1.000 22.09289  ? 219 PHE A CB  1 
ATOM   1691 C CG  . PHE A 1 219 ? 1.58699  -38.40412 14.18809  1.000 18.87878  ? 219 PHE A CG  1 
ATOM   1692 C CD1 . PHE A 1 219 ? 2.51318  -37.77723 15.00948  1.000 20.12006  ? 219 PHE A CD1 1 
ATOM   1693 C CD2 . PHE A 1 219 ? 0.48829  -37.66874 13.72456  1.000 20.43065  ? 219 PHE A CD2 1 
ATOM   1694 C CE1 . PHE A 1 219 ? 2.36485  -36.43132 15.35164  1.000 19.60653  ? 219 PHE A CE1 1 
ATOM   1695 C CE2 . PHE A 1 219 ? 0.31923  -36.33649 14.07608  1.000 20.68956  ? 219 PHE A CE2 1 
ATOM   1696 C CZ  . PHE A 1 219 ? 1.26371  -35.70641 14.88614  1.000 17.00213  ? 219 PHE A CZ  1 
ATOM   1697 N N   . LEU A 1 220 ? 1.59603  -40.35724 17.32376  1.000 20.07382  ? 220 LEU A N   1 
ATOM   1698 C CA  . LEU A 1 220 ? 2.44983  -40.41963 18.50029  1.000 21.90185  ? 220 LEU A CA  1 
ATOM   1699 C C   . LEU A 1 220 ? 2.61102  -41.87228 18.96634  1.000 21.44913  ? 220 LEU A C   1 
ATOM   1700 O O   . LEU A 1 220 ? 1.84801  -42.76321 18.58353  1.000 22.07342  ? 220 LEU A O   1 
ATOM   1701 C CB  . LEU A 1 220 ? 1.88859  -39.56718 19.63563  1.000 21.17655  ? 220 LEU A CB  1 
ATOM   1702 C CG  . LEU A 1 220 ? 1.74676  -38.08950 19.32642  1.000 24.74761  ? 220 LEU A CG  1 
ATOM   1703 C CD1 . LEU A 1 220 ? 1.22840  -37.34232 20.50109  1.000 25.52563  ? 220 LEU A CD1 1 
ATOM   1704 C CD2 . LEU A 1 220 ? 3.09663  -37.51705 18.87988  1.000 18.36721  ? 220 LEU A CD2 1 
ATOM   1705 N N   . ASN A 1 221 ? 3.64434  -42.10894 19.77480  1.000 25.15241  ? 221 ASN A N   1 
ATOM   1706 C CA  . ASN A 1 221 ? 3.83133  -43.41590 20.40155  1.000 26.53727  ? 221 ASN A CA  1 
ATOM   1707 C C   . ASN A 1 221 ? 4.49730  -43.20761 21.75453  1.000 19.73611  ? 221 ASN A C   1 
ATOM   1708 O O   . ASN A 1 221 ? 4.77239  -42.08066 22.17104  1.000 22.84219  ? 221 ASN A O   1 
ATOM   1709 C CB  . ASN A 1 221 ? 4.62268  -44.38134 19.51171  1.000 24.94965  ? 221 ASN A CB  1 
ATOM   1710 C CG  . ASN A 1 221 ? 5.96357  -43.82038 19.05093  1.000 33.76382  ? 221 ASN A CG  1 
ATOM   1711 O OD1 . ASN A 1 221 ? 6.76327  -43.34683 19.86077  1.000 27.72860  ? 221 ASN A OD1 1 
ATOM   1712 N ND2 . ASN A 1 221 ? 6.23799  -43.93656 17.74955  1.000 36.49144  ? 221 ASN A ND2 1 
ATOM   1713 N N   . ARG A 1 222 ? 4.74594  -44.31187 22.46688  1.000 30.04387  ? 222 ARG A N   1 
ATOM   1714 C CA  . ARG A 1 222 ? 5.29607  -44.18744 23.81111  1.000 35.09044  ? 222 ARG A CA  1 
ATOM   1715 C C   . ARG A 1 222 ? 6.81522  -44.30695 23.82763  1.000 34.48365  ? 222 ARG A C   1 
ATOM   1716 O O   . ARG A 1 222 ? 7.43211  -44.11641 24.88023  1.000 43.06420  ? 222 ARG A O   1 
ATOM   1717 C CB  . ARG A 1 222 ? 4.68597  -45.24726 24.74076  1.000 43.46605  ? 222 ARG A CB  1 
ATOM   1718 C CG  . ARG A 1 222 ? 5.16915  -46.63351 24.39015  1.000 43.31383  ? 222 ARG A CG  1 
ATOM   1719 C CD  . ARG A 1 222 ? 4.75024  -47.70389 25.38024  1.000 50.75174  ? 222 ARG A CD  1 
ATOM   1720 N NE  . ARG A 1 222 ? 5.54505  -48.90699 25.16717  1.000 59.90629  ? 222 ARG A NE  1 
ATOM   1721 C CZ  . ARG A 1 222 ? 5.36169  -49.76346 24.17120  1.000 59.90436  ? 222 ARG A CZ  1 
ATOM   1722 N NH1 . ARG A 1 222 ? 4.42726  -49.56604 23.25355  1.000 57.89620  ? 222 ARG A NH1 1 
ATOM   1723 N NH2 . ARG A 1 222 ? 6.14663  -50.83768 24.08491  1.000 60.63708  ? 222 ARG A NH2 1 
ATOM   1724 N N   . PHE A 1 223 ? 7.43599  -44.58138 22.68943  1.000 33.95800  ? 223 PHE A N   1 
ATOM   1725 C CA  . PHE A 1 223 ? 8.87948  -44.73391 22.66565  1.000 39.51615  ? 223 PHE A CA  1 
ATOM   1726 C C   . PHE A 1 223 ? 9.59032  -43.38461 22.70711  1.000 46.09736  ? 223 PHE A C   1 
ATOM   1727 O O   . PHE A 1 223 ? 9.00754  -42.33007 22.42730  1.000 40.21088  ? 223 PHE A O   1 
ATOM   1728 C CB  . PHE A 1 223 ? 9.29549  -45.51841 21.43339  1.000 34.32287  ? 223 PHE A CB  1 
ATOM   1729 C CG  . PHE A 1 223 ? 8.48606  -46.75378 21.22650  1.000 50.77088  ? 223 PHE A CG  1 
ATOM   1730 C CD1 . PHE A 1 223 ? 8.67159  -47.85617 22.05636  1.000 54.91514  ? 223 PHE A CD1 1 
ATOM   1731 C CD2 . PHE A 1 223 ? 7.55058  -46.83056 20.20609  1.000 51.53872  ? 223 PHE A CD2 1 
ATOM   1732 C CE1 . PHE A 1 223 ? 7.93056  -49.01199 21.88273  1.000 48.38376  ? 223 PHE A CE1 1 
ATOM   1733 C CE2 . PHE A 1 223 ? 6.80531  -47.98835 20.01927  1.000 64.28990  ? 223 PHE A CE2 1 
ATOM   1734 C CZ  . PHE A 1 223 ? 6.99816  -49.08248 20.86081  1.000 63.79081  ? 223 PHE A CZ  1 
ATOM   1735 N N   . THR A 1 224 ? 10.85498 -43.43212 23.11922  1.000 42.59263  ? 224 THR A N   1 
ATOM   1736 C CA  . THR A 1 224 ? 11.81918 -42.35991 22.93772  1.000 37.96933  ? 224 THR A CA  1 
ATOM   1737 C C   . THR A 1 224 ? 12.94428 -42.95331 22.10318  1.000 40.19805  ? 224 THR A C   1 
ATOM   1738 O O   . THR A 1 224 ? 13.01482 -44.16763 21.87799  1.000 35.45700  ? 224 THR A O   1 
ATOM   1739 C CB  . THR A 1 224 ? 12.35639 -41.81577 24.27955  1.000 37.66929  ? 224 THR A CB  1 
ATOM   1740 O OG1 . THR A 1 224 ? 11.26378 -41.36919 25.08604  1.000 69.00834  ? 224 THR A OG1 1 
ATOM   1741 C CG2 . THR A 1 224 ? 13.24242 -40.57721 24.07863  1.000 40.15812  ? 224 THR A CG2 1 
ATOM   1742 N N   . THR A 1 225 ? 13.80250 -42.08253 21.60411  1.000 44.21656  ? 225 THR A N   1 
ATOM   1743 C CA  . THR A 1 225 ? 14.96299 -42.49556 20.83823  1.000 32.15480  ? 225 THR A CA  1 
ATOM   1744 C C   . THR A 1 225 ? 16.10093 -41.60990 21.29570  1.000 24.67755  ? 225 THR A C   1 
ATOM   1745 O O   . THR A 1 225 ? 15.88771 -40.57230 21.92489  1.000 28.80611  ? 225 THR A O   1 
ATOM   1746 C CB  . THR A 1 225 ? 14.69765 -42.37289 19.33379  1.000 28.05516  ? 225 THR A CB  1 
ATOM   1747 O OG1 . THR A 1 225 ? 15.77818 -42.94485 18.58734  1.000 33.32438  ? 225 THR A OG1 1 
ATOM   1748 C CG2 . THR A 1 225 ? 14.56274 -40.88189 18.96373  1.000 26.36902  ? 225 THR A CG2 1 
ATOM   1749 N N   . THR A 1 226 ? 17.32340 -42.05632 21.05241  1.000 32.51051  ? 226 THR A N   1 
ATOM   1750 C CA  . THR A 1 226 ? 18.46555 -41.18043 21.25320  1.000 33.40179  ? 226 THR A CA  1 
ATOM   1751 C C   . THR A 1 226 ? 18.68685 -40.35055 20.00025  1.000 29.35867  ? 226 THR A C   1 
ATOM   1752 O O   . THR A 1 226 ? 18.29217 -40.74431 18.89471  1.000 30.24574  ? 226 THR A O   1 
ATOM   1753 C CB  . THR A 1 226 ? 19.72421 -41.98875 21.61073  1.000 29.89359  ? 226 THR A CB  1 
ATOM   1754 O OG1 . THR A 1 226 ? 20.27874 -42.59511 20.43208  1.000 30.70427  ? 226 THR A OG1 1 
ATOM   1755 C CG2 . THR A 1 226 ? 19.40027 -43.07442 22.63329  1.000 28.81075  ? 226 THR A CG2 1 
ATOM   1756 N N   . LEU A 1 227 ? 19.31349 -39.18732 20.18275  1.000 24.16900  ? 227 LEU A N   1 
ATOM   1757 C CA  . LEU A 1 227 ? 19.67429 -38.37994 19.02233  1.000 35.16089  ? 227 LEU A CA  1 
ATOM   1758 C C   . LEU A 1 227 ? 20.49885 -39.19745 18.03130  1.000 36.37021  ? 227 LEU A C   1 
ATOM   1759 O O   . LEU A 1 227 ? 20.14320 -39.31355 16.84641  1.000 29.28184  ? 227 LEU A O   1 
ATOM   1760 C CB  . LEU A 1 227 ? 20.41789 -37.13362 19.47759  1.000 31.86384  ? 227 LEU A CB  1 
ATOM   1761 C CG  . LEU A 1 227 ? 20.66171 -36.03727 18.44218  1.000 26.38383  ? 227 LEU A CG  1 
ATOM   1762 C CD1 . LEU A 1 227 ? 19.37860 -35.73970 17.63226  1.000 36.17601  ? 227 LEU A CD1 1 
ATOM   1763 C CD2 . LEU A 1 227 ? 21.10849 -34.77850 19.17864  1.000 31.08581  ? 227 LEU A CD2 1 
ATOM   1764 N N   . ASN A 1 228 ? 21.56675 -39.84320 18.52246  1.000 30.20868  ? 228 ASN A N   1 
ATOM   1765 C CA  . ASN A 1 228 ? 22.40571 -40.66856 17.65352  1.000 29.78745  ? 228 ASN A CA  1 
ATOM   1766 C C   . ASN A 1 228 ? 21.60835 -41.73206 16.90483  1.000 28.31495  ? 228 ASN A C   1 
ATOM   1767 O O   . ASN A 1 228 ? 21.82716 -41.95519 15.70576  1.000 37.71781  ? 228 ASN A O   1 
ATOM   1768 C CB  . ASN A 1 228 ? 23.53224 -41.30623 18.47742  1.000 40.68641  ? 228 ASN A CB  1 
ATOM   1769 C CG  . ASN A 1 228 ? 24.48023 -40.26904 19.09130  1.000 57.02619  ? 228 ASN A CG  1 
ATOM   1770 O OD1 . ASN A 1 228 ? 24.07108 -39.17846 19.51069  1.000 51.69294  ? 228 ASN A OD1 1 
ATOM   1771 N ND2 . ASN A 1 228 ? 25.75959 -40.62719 19.16812  1.000 57.49875  ? 228 ASN A ND2 1 
ATOM   1772 N N   . ASP A 1 229 ? 20.68193 -42.41308 17.58810  1.000 29.59924  ? 229 ASP A N   1 
ATOM   1773 C CA  . ASP A 1 229 ? 19.94277 -43.47119 16.91378  1.000 24.23627  ? 229 ASP A CA  1 
ATOM   1774 C C   . ASP A 1 229 ? 18.95864 -42.88501 15.91129  1.000 34.80355  ? 229 ASP A C   1 
ATOM   1775 O O   . ASP A 1 229 ? 18.75258 -43.44948 14.82796  1.000 35.58837  ? 229 ASP A O   1 
ATOM   1776 C CB  . ASP A 1 229 ? 19.20027 -44.34187 17.93651  1.000 21.45985  ? 229 ASP A CB  1 
ATOM   1777 C CG  . ASP A 1 229 ? 20.10808 -45.36694 18.60782  1.000 47.33939  ? 229 ASP A CG  1 
ATOM   1778 O OD1 . ASP A 1 229 ? 21.21063 -45.63987 18.08818  1.000 34.13632  ? 229 ASP A OD1 1 
ATOM   1779 O OD2 . ASP A 1 229 ? 19.71990 -45.88631 19.66845  1.000 42.01828  ? 229 ASP A OD2 1 
ATOM   1780 N N   . PHE A 1 230 ? 18.31942 -41.76735 16.26645  1.000 26.70673  ? 230 PHE A N   1 
ATOM   1781 C CA  . PHE A 1 230 ? 17.42292 -41.13449 15.30453  1.000 25.66766  ? 230 PHE A CA  1 
ATOM   1782 C C   . PHE A 1 230 ? 18.19706 -40.74077 14.04669  1.000 23.24462  ? 230 PHE A C   1 
ATOM   1783 O O   . PHE A 1 230 ? 17.79491 -41.07503 12.92068  1.000 29.32477  ? 230 PHE A O   1 
ATOM   1784 C CB  . PHE A 1 230 ? 16.70724 -39.92033 15.91284  1.000 19.29721  ? 230 PHE A CB  1 
ATOM   1785 C CG  . PHE A 1 230 ? 15.92321 -39.16784 14.88282  1.000 25.45967  ? 230 PHE A CG  1 
ATOM   1786 C CD1 . PHE A 1 230 ? 14.66069 -39.62166 14.49255  1.000 26.64984  ? 230 PHE A CD1 1 
ATOM   1787 C CD2 . PHE A 1 230 ? 16.47978 -38.07135 14.23762  1.000 26.69633  ? 230 PHE A CD2 1 
ATOM   1788 C CE1 . PHE A 1 230 ? 13.96631 -38.98859 13.50570  1.000 25.68058  ? 230 PHE A CE1 1 
ATOM   1789 C CE2 . PHE A 1 230 ? 15.77335 -37.41752 13.24922  1.000 28.36926  ? 230 PHE A CE2 1 
ATOM   1790 C CZ  . PHE A 1 230 ? 14.51018 -37.88089 12.88625  1.000 26.34103  ? 230 PHE A CZ  1 
ATOM   1791 N N   . ASN A 1 231 ? 19.36138 -40.11549 14.23617  1.000 31.05876  ? 231 ASN A N   1 
ATOM   1792 C CA  . ASN A 1 231 ? 20.15291 -39.64160 13.10159  1.000 29.12431  ? 231 ASN A CA  1 
ATOM   1793 C C   . ASN A 1 231 ? 20.57834 -40.78370 12.20055  1.000 29.25990  ? 231 ASN A C   1 
ATOM   1794 O O   . ASN A 1 231 ? 20.73155 -40.58698 10.98968  1.000 28.48792  ? 231 ASN A O   1 
ATOM   1795 C CB  . ASN A 1 231 ? 21.34215 -38.83902 13.61289  1.000 24.46273  ? 231 ASN A CB  1 
ATOM   1796 C CG  . ASN A 1 231 ? 20.96821 -37.40594 13.89347  1.000 22.25872  ? 231 ASN A CG  1 
ATOM   1797 O OD1 . ASN A 1 231 ? 20.06119 -36.87108 13.23491  1.000 38.30456  ? 231 ASN A OD1 1 
ATOM   1798 N ND2 . ASN A 1 231 ? 21.53668 -36.82059 14.93898  1.000 26.54348  ? 231 ASN A ND2 1 
ATOM   1799 N N   . LEU A 1 232 ? 20.71059 -41.99732 12.75466  1.000 29.98713  ? 232 LEU A N   1 
ATOM   1800 C CA  . LEU A 1 232 ? 20.96458 -43.16296 11.91520  1.000 20.89487  ? 232 LEU A CA  1 
ATOM   1801 C C   . LEU A 1 232 ? 19.80046 -43.44034 10.97858  1.000 33.97335  ? 232 LEU A C   1 
ATOM   1802 O O   . LEU A 1 232 ? 20.01192 -43.77693 9.80609   1.000 34.02034  ? 232 LEU A O   1 
ATOM   1803 C CB  . LEU A 1 232 ? 21.25062 -44.38607 12.78768  1.000 38.74532  ? 232 LEU A CB  1 
ATOM   1804 C CG  . LEU A 1 232 ? 22.59047 -44.39197 13.53033  1.000 37.91569  ? 232 LEU A CG  1 
ATOM   1805 C CD1 . LEU A 1 232 ? 22.71052 -45.61840 14.41650  1.000 39.50252  ? 232 LEU A CD1 1 
ATOM   1806 C CD2 . LEU A 1 232 ? 23.70258 -44.38397 12.52218  1.000 41.24471  ? 232 LEU A CD2 1 
ATOM   1807 N N   . VAL A 1 233 ? 18.56231 -43.32670 11.48007  1.000 24.59788  ? 233 VAL A N   1 
ATOM   1808 C CA  . VAL A 1 233 ? 17.40001 -43.55897 10.62421  1.000 31.66111  ? 233 VAL A CA  1 
ATOM   1809 C C   . VAL A 1 233 ? 17.21883 -42.40143 9.64472   1.000 30.38691  ? 233 VAL A C   1 
ATOM   1810 O O   . VAL A 1 233 ? 16.88028 -42.61009 8.47065   1.000 31.94882  ? 233 VAL A O   1 
ATOM   1811 C CB  . VAL A 1 233 ? 16.14043 -43.79282 11.48268  1.000 41.19237  ? 233 VAL A CB  1 
ATOM   1812 C CG1 . VAL A 1 233 ? 14.89134 -43.89589 10.60167  1.000 30.61806  ? 233 VAL A CG1 1 
ATOM   1813 C CG2 . VAL A 1 233 ? 16.30798 -45.05240 12.32772  1.000 38.16038  ? 233 VAL A CG2 1 
ATOM   1814 N N   . ALA A 1 234 ? 17.46554 -41.16887 10.10908  1.000 29.67592  ? 234 ALA A N   1 
ATOM   1815 C CA  . ALA A 1 234 ? 17.41006 -40.00063 9.23786   1.000 34.09862  ? 234 ALA A CA  1 
ATOM   1816 C C   . ALA A 1 234 ? 18.28080 -40.20314 8.00815   1.000 38.35268  ? 234 ALA A C   1 
ATOM   1817 O O   . ALA A 1 234 ? 17.84190 -39.98639 6.86937   1.000 33.09977  ? 234 ALA A O   1 
ATOM   1818 C CB  . ALA A 1 234 ? 17.86252 -38.74599 9.99850   1.000 27.29414  ? 234 ALA A CB  1 
ATOM   1819 N N   . MET A 1 235 ? 19.52190 -40.64124 8.21803   1.000 33.74522  ? 235 MET A N   1 
ATOM   1820 C CA  . MET A 1 235 ? 20.41289 -40.69949 7.07375   1.000 27.00949  ? 235 MET A CA  1 
ATOM   1821 C C   . MET A 1 235 ? 19.94281 -41.77005 6.10015   1.000 32.72551  ? 235 MET A C   1 
ATOM   1822 O O   . MET A 1 235 ? 19.98975 -41.55004 4.88513   1.000 37.59523  ? 235 MET A O   1 
ATOM   1823 C CB  . MET A 1 235 ? 21.85201 -40.88321 7.53823   1.000 36.43177  ? 235 MET A CB  1 
ATOM   1824 C CG  . MET A 1 235 ? 22.81471 -41.37753 6.47275   1.000 45.49135  ? 235 MET A CG  1 
ATOM   1825 S SD  . MET A 1 235 ? 24.37621 -41.86684 7.22715   1.000 61.11987  ? 235 MET A SD  1 
ATOM   1826 C CE  . MET A 1 235 ? 25.23570 -40.29965 7.24261   1.000 47.26035  ? 235 MET A CE  1 
ATOM   1827 N N   . LYS A 1 236 ? 19.35182 -42.86633 6.60302   1.000 24.54150  ? 236 LYS A N   1 
ATOM   1828 C CA  . LYS A 1 236 ? 18.90349 -43.91617 5.69553   1.000 35.64372  ? 236 LYS A CA  1 
ATOM   1829 C C   . LYS A 1 236 ? 17.73084 -43.46200 4.82102   1.000 33.14017  ? 236 LYS A C   1 
ATOM   1830 O O   . LYS A 1 236 ? 17.58551 -43.93140 3.68703   1.000 34.20849  ? 236 LYS A O   1 
ATOM   1831 C CB  . LYS A 1 236 ? 18.55756 -45.17838 6.49617   1.000 34.05140  ? 236 LYS A CB  1 
ATOM   1832 C CG  . LYS A 1 236 ? 17.36105 -45.95081 5.99187   1.000 42.51737  ? 236 LYS A CG  1 
ATOM   1833 C CD  . LYS A 1 236 ? 17.32239 -47.35859 6.59069   1.000 44.43730  ? 236 LYS A CD  1 
ATOM   1834 C CE  . LYS A 1 236 ? 15.99222 -48.05358 6.26705   1.000 51.58175  ? 236 LYS A CE  1 
ATOM   1835 N NZ  . LYS A 1 236 ? 16.03524 -49.53614 6.43232   1.000 48.80643  ? 236 LYS A NZ  1 
ATOM   1836 N N   . TYR A 1 237 ? 16.90666 -42.52587 5.29404   1.000 32.70536  ? 237 TYR A N   1 
ATOM   1837 C CA  . TYR A 1 237 ? 15.76364 -42.04681 4.52259   1.000 27.15127  ? 237 TYR A CA  1 
ATOM   1838 C C   . TYR A 1 237 ? 16.01543 -40.69371 3.85752   1.000 30.11031  ? 237 TYR A C   1 
ATOM   1839 O O   . TYR A 1 237 ? 15.05304 -40.02711 3.44654   1.000 25.11069  ? 237 TYR A O   1 
ATOM   1840 C CB  . TYR A 1 237 ? 14.52292 -41.97495 5.41211   1.000 30.56290  ? 237 TYR A CB  1 
ATOM   1841 C CG  . TYR A 1 237 ? 13.97607 -43.34250 5.74287   1.000 24.61585  ? 237 TYR A CG  1 
ATOM   1842 C CD1 . TYR A 1 237 ? 13.08165 -43.97298 4.87577   1.000 25.77338  ? 237 TYR A CD1 1 
ATOM   1843 C CD2 . TYR A 1 237 ? 14.34811 -44.00337 6.90923   1.000 33.00427  ? 237 TYR A CD2 1 
ATOM   1844 C CE1 . TYR A 1 237 ? 12.58054 -45.22934 5.15366   1.000 31.12014  ? 237 TYR A CE1 1 
ATOM   1845 C CE2 . TYR A 1 237 ? 13.85566 -45.25852 7.19086   1.000 31.08606  ? 237 TYR A CE2 1 
ATOM   1846 C CZ  . TYR A 1 237 ? 12.97295 -45.86467 6.31262   1.000 32.96858  ? 237 TYR A CZ  1 
ATOM   1847 O OH  . TYR A 1 237 ? 12.45950 -47.11604 6.59442   1.000 37.41750  ? 237 TYR A OH  1 
ATOM   1848 N N   . ASN A 1 238 ? 17.28711 -40.28316 3.73674   1.000 25.51997  ? 238 ASN A N   1 
ATOM   1849 C CA  . ASN A 1 238 ? 17.65877 -39.05850 3.01883   1.000 25.25142  ? 238 ASN A CA  1 
ATOM   1850 C C   . ASN A 1 238 ? 17.14240 -37.80757 3.73978   1.000 25.55392  ? 238 ASN A C   1 
ATOM   1851 O O   . ASN A 1 238 ? 16.71902 -36.84252 3.10782   1.000 22.24042  ? 238 ASN A O   1 
ATOM   1852 C CB  . ASN A 1 238 ? 17.15129 -39.11127 1.57657   1.000 30.85131  ? 238 ASN A CB  1 
ATOM   1853 C CG  . ASN A 1 238 ? 17.85624 -38.14806 0.66707   1.000 38.74558  ? 238 ASN A CG  1 
ATOM   1854 O OD1 . ASN A 1 238 ? 19.07483 -37.96753 0.74053   1.000 48.31604  ? 238 ASN A OD1 1 
ATOM   1855 N ND2 . ASN A 1 238 ? 17.07827 -37.48582 -0.19044  1.000 36.17776  ? 238 ASN A ND2 1 
ATOM   1856 N N   . TYR A 1 239 ? 17.18744 -37.82894 5.06502   1.000 23.02934  ? 239 TYR A N   1 
ATOM   1857 C CA  . TYR A 1 239 ? 16.82061 -36.70759 5.91008   1.000 19.71014  ? 239 TYR A CA  1 
ATOM   1858 C C   . TYR A 1 239 ? 18.07684 -36.01501 6.42351   1.000 28.42167  ? 239 TYR A C   1 
ATOM   1859 O O   . TYR A 1 239 ? 19.09817 -36.66130 6.66388   1.000 25.85518  ? 239 TYR A O   1 
ATOM   1860 C CB  . TYR A 1 239 ? 15.97693 -37.20416 7.09445   1.000 17.45332  ? 239 TYR A CB  1 
ATOM   1861 C CG  . TYR A 1 239 ? 14.48452 -37.19462 6.85947   1.000 15.70777  ? 239 TYR A CG  1 
ATOM   1862 C CD1 . TYR A 1 239 ? 13.91260 -37.83698 5.75898   1.000 20.75169  ? 239 TYR A CD1 1 
ATOM   1863 C CD2 . TYR A 1 239 ? 13.65034 -36.52261 7.73912   1.000 21.89767  ? 239 TYR A CD2 1 
ATOM   1864 C CE1 . TYR A 1 239 ? 12.49357 -37.83277 5.54638   1.000 17.07026  ? 239 TYR A CE1 1 
ATOM   1865 C CE2 . TYR A 1 239 ? 12.28116 -36.50799 7.54451   1.000 14.71881  ? 239 TYR A CE2 1 
ATOM   1866 C CZ  . TYR A 1 239 ? 11.70332 -37.15613 6.46248   1.000 14.49248  ? 239 TYR A CZ  1 
ATOM   1867 O OH  . TYR A 1 239 ? 10.31271 -37.07154 6.32717   1.000 19.09571  ? 239 TYR A OH  1 
ATOM   1868 N N   . GLU A 1 240 ? 17.99735 -34.69245 6.59742   1.000 20.73929  ? 240 GLU A N   1 
ATOM   1869 C CA  . GLU A 1 240 ? 19.12223 -33.93874 7.14477   1.000 21.38095  ? 240 GLU A CA  1 
ATOM   1870 C C   . GLU A 1 240 ? 19.42736 -34.41931 8.55963   1.000 31.61962  ? 240 GLU A C   1 
ATOM   1871 O O   . GLU A 1 240 ? 18.50659 -34.73889 9.31648   1.000 18.91681  ? 240 GLU A O   1 
ATOM   1872 C CB  . GLU A 1 240 ? 18.83505 -32.43465 7.20699   1.000 20.82838  ? 240 GLU A CB  1 
ATOM   1873 C CG  . GLU A 1 240 ? 18.85051 -31.74254 5.85323   1.000 25.10367  ? 240 GLU A CG  1 
ATOM   1874 C CD  . GLU A 1 240 ? 20.24033 -31.38379 5.39949   1.000 48.86119  ? 240 GLU A CD  1 
ATOM   1875 O OE1 . GLU A 1 240 ? 20.83016 -30.45788 6.00106   1.000 43.09820  ? 240 GLU A OE1 1 
ATOM   1876 O OE2 . GLU A 1 240 ? 20.74675 -32.04657 4.45686   1.000 41.72146  ? 240 GLU A OE2 1 
ATOM   1877 N N   . PRO A 1 241 ? 20.69533 -34.46336 8.95506   1.000 33.09628  ? 241 PRO A N   1 
ATOM   1878 C CA  . PRO A 1 241 ? 20.99278 -34.71732 10.36885  1.000 20.44546  ? 241 PRO A CA  1 
ATOM   1879 C C   . PRO A 1 241 ? 20.28321 -33.70076 11.25831  1.000 24.97663  ? 241 PRO A C   1 
ATOM   1880 O O   . PRO A 1 241 ? 20.16324 -32.51623 10.91737  1.000 28.71378  ? 241 PRO A O   1 
ATOM   1881 C CB  . PRO A 1 241 ? 22.52071 -34.57403 10.44641  1.000 26.19817  ? 241 PRO A CB  1 
ATOM   1882 C CG  . PRO A 1 241 ? 23.00215 -34.85868 9.02666   1.000 28.16642  ? 241 PRO A CG  1 
ATOM   1883 C CD  . PRO A 1 241 ? 21.91262 -34.30395 8.13177   1.000 29.04632  ? 241 PRO A CD  1 
ATOM   1884 N N   . LEU A 1 242 ? 19.77187 -34.18212 12.38859  1.000 20.76942  ? 242 LEU A N   1 
ATOM   1885 C CA  . LEU A 1 242 ? 19.22371 -33.32433 13.44244  1.000 20.41176  ? 242 LEU A CA  1 
ATOM   1886 C C   . LEU A 1 242 ? 20.30159 -33.04321 14.48290  1.000 26.69337  ? 242 LEU A C   1 
ATOM   1887 O O   . LEU A 1 242 ? 20.93589 -33.97248 14.99396  1.000 27.60108  ? 242 LEU A O   1 
ATOM   1888 C CB  . LEU A 1 242 ? 18.01645 -33.99397 14.12805  1.000 21.84601  ? 242 LEU A CB  1 
ATOM   1889 C CG  . LEU A 1 242 ? 17.09557 -33.11638 14.97773  1.000 18.81028  ? 242 LEU A CG  1 
ATOM   1890 C CD1 . LEU A 1 242 ? 16.23746 -32.23181 14.06878  1.000 21.15256  ? 242 LEU A CD1 1 
ATOM   1891 C CD2 . LEU A 1 242 ? 16.23065 -33.94264 15.92347  1.000 20.59803  ? 242 LEU A CD2 1 
ATOM   1892 N N   . THR A 1 243 ? 20.48834 -31.77506 14.81865  1.000 28.19185  ? 243 THR A N   1 
ATOM   1893 C CA  . THR A 1 243 ? 21.53734 -31.39046 15.74608  1.000 23.45623  ? 243 THR A CA  1 
ATOM   1894 C C   . THR A 1 243 ? 20.93020 -31.04282 17.09464  1.000 36.83542  ? 243 THR A C   1 
ATOM   1895 O O   . THR A 1 243 ? 19.72893 -30.80429 17.22962  1.000 27.25017  ? 243 THR A O   1 
ATOM   1896 C CB  . THR A 1 243 ? 22.32983 -30.18348 15.22802  1.000 27.20027  ? 243 THR A CB  1 
ATOM   1897 O OG1 . THR A 1 243 ? 21.48902 -29.00905 15.23317  1.000 24.44418  ? 243 THR A OG1 1 
ATOM   1898 C CG2 . THR A 1 243 ? 22.87070 -30.45544 13.81786  1.000 27.68651  ? 243 THR A CG2 1 
ATOM   1899 N N   . GLN A 1 244 ? 21.79352 -30.96358 18.10086  1.000 27.63319  ? 244 GLN A N   1 
ATOM   1900 C CA  . GLN A 1 244 ? 21.34328 -30.45591 19.39205  1.000 30.09719  ? 244 GLN A CA  1 
ATOM   1901 C C   . GLN A 1 244 ? 20.79117 -29.04266 19.27316  1.000 25.37273  ? 244 GLN A C   1 
ATOM   1902 O O   . GLN A 1 244 ? 19.90892 -28.63932 20.05393  1.000 31.59477  ? 244 GLN A O   1 
ATOM   1903 C CB  . GLN A 1 244 ? 22.49991 -30.49591 20.39720  1.000 32.23704  ? 244 GLN A CB  1 
ATOM   1904 C CG  . GLN A 1 244 ? 22.05797 -30.13045 21.80243  1.000 43.96627  ? 244 GLN A CG  1 
ATOM   1905 C CD  . GLN A 1 244 ? 20.89983 -30.99027 22.25805  1.000 31.36093  ? 244 GLN A CD  1 
ATOM   1906 O OE1 . GLN A 1 244 ? 19.93349 -30.49268 22.81360  1.000 34.82325  ? 244 GLN A OE1 1 
ATOM   1907 N NE2 . GLN A 1 244 ? 21.00524 -32.29889 22.02158  1.000 41.06927  ? 244 GLN A NE2 1 
ATOM   1908 N N   . ASP A 1 245 ? 21.29743 -28.26934 18.31677  1.000 22.28080  ? 245 ASP A N   1 
ATOM   1909 C CA  . ASP A 1 245 ? 20.73917 -26.94231 18.08997  1.000 25.67895  ? 245 ASP A CA  1 
ATOM   1910 C C   . ASP A 1 245 ? 19.29535 -27.02785 17.59186  1.000 18.67951  ? 245 ASP A C   1 
ATOM   1911 O O   . ASP A 1 245 ? 18.44221 -26.22450 17.97916  1.000 25.29390  ? 245 ASP A O   1 
ATOM   1912 C CB  . ASP A 1 245 ? 21.58383 -26.18939 17.07661  1.000 29.15034  ? 245 ASP A CB  1 
ATOM   1913 C CG  . ASP A 1 245 ? 21.47476 -24.70152 17.23580  1.000 37.31489  ? 245 ASP A CG  1 
ATOM   1914 O OD1 . ASP A 1 245 ? 21.50832 -24.24046 18.39830  1.000 40.02491  ? 245 ASP A OD1 1 
ATOM   1915 O OD2 . ASP A 1 245 ? 21.32527 -24.00141 16.20016  1.000 42.15109  ? 245 ASP A OD2 1 
ATOM   1916 N N   . HIS A 1 246 ? 19.02045 -27.96597 16.70173  1.000 26.83950  ? 246 HIS A N   1 
ATOM   1917 C CA  . HIS A 1 246 ? 17.64316 -28.16028 16.25380  1.000 17.69676  ? 246 HIS A CA  1 
ATOM   1918 C C   . HIS A 1 246 ? 16.75119 -28.53271 17.41319  1.000 26.51248  ? 246 HIS A C   1 
ATOM   1919 O O   . HIS A 1 246 ? 15.63707 -28.01173 17.54148  1.000 22.36167  ? 246 HIS A O   1 
ATOM   1920 C CB  . HIS A 1 246 ? 17.61062 -29.25263 15.21277  1.000 20.83543  ? 246 HIS A CB  1 
ATOM   1921 C CG  . HIS A 1 246 ? 18.29114 -28.86526 13.95115  1.000 21.76319  ? 246 HIS A CG  1 
ATOM   1922 N ND1 . HIS A 1 246 ? 19.05250 -29.74346 13.20908  1.000 20.15191  ? 246 HIS A ND1 1 
ATOM   1923 C CD2 . HIS A 1 246 ? 18.29699 -27.68770 13.28469  1.000 18.83987  ? 246 HIS A CD2 1 
ATOM   1924 C CE1 . HIS A 1 246 ? 19.50386 -29.11669 12.13438  1.000 30.60111  ? 246 HIS A CE1 1 
ATOM   1925 N NE2 . HIS A 1 246 ? 19.06044 -27.86935 12.15653  1.000 23.48997  ? 246 HIS A NE2 1 
ATOM   1926 N N   . VAL A 1 247 ? 17.22263 -29.45738 18.25423  1.000 19.84418  ? 247 VAL A N   1 
ATOM   1927 C CA  . VAL A 1 247 ? 16.47815 -29.84969 19.44886  1.000 18.55682  ? 247 VAL A CA  1 
ATOM   1928 C C   . VAL A 1 247 ? 16.14395 -28.62760 20.27415  1.000 21.73455  ? 247 VAL A C   1 
ATOM   1929 O O   . VAL A 1 247 ? 14.99531 -28.42530 20.69090  1.000 25.75860  ? 247 VAL A O   1 
ATOM   1930 C CB  . VAL A 1 247 ? 17.28089 -30.88020 20.26830  1.000 24.71765  ? 247 VAL A CB  1 
ATOM   1931 C CG1 . VAL A 1 247 ? 16.55424 -31.19907 21.56951  1.000 30.83192  ? 247 VAL A CG1 1 
ATOM   1932 C CG2 . VAL A 1 247 ? 17.46213 -32.15776 19.47053  1.000 25.16351  ? 247 VAL A CG2 1 
ATOM   1933 N N   . ASP A 1 248 ? 17.15056 -27.78817 20.52464  1.000 26.64596  ? 248 ASP A N   1 
ATOM   1934 C CA  . ASP A 1 248 ? 16.92905 -26.57370 21.30196  1.000 25.74008  ? 248 ASP A CA  1 
ATOM   1935 C C   . ASP A 1 248 ? 15.91712 -25.65452 20.63368  1.000 26.43550  ? 248 ASP A C   1 
ATOM   1936 O O   . ASP A 1 248 ? 15.07232 -25.07247 21.31692  1.000 27.68108  ? 248 ASP A O   1 
ATOM   1937 C CB  . ASP A 1 248 ? 18.24753 -25.83251 21.53170  1.000 32.10132  ? 248 ASP A CB  1 
ATOM   1938 C CG  . ASP A 1 248 ? 19.23504 -26.64314 22.34687  1.000 42.46787  ? 248 ASP A CG  1 
ATOM   1939 O OD1 . ASP A 1 248 ? 18.78651 -27.39309 23.24692  1.000 48.76767  ? 248 ASP A OD1 1 
ATOM   1940 O OD2 . ASP A 1 248 ? 20.45209 -26.53194 22.08823  1.000 44.99005  ? 248 ASP A OD2 1 
ATOM   1941 N N   . ILE A 1 249 ? 15.98581 -25.50684 19.29879  1.000 23.33196  ? 249 ILE A N   1 
ATOM   1942 C CA  . ILE A 1 249 ? 15.04530 -24.62175 18.60521  1.000 21.04776  ? 249 ILE A CA  1 
ATOM   1943 C C   . ILE A 1 249 ? 13.61810 -25.12658 18.75478  1.000 25.81363  ? 249 ILE A C   1 
ATOM   1944 O O   . ILE A 1 249 ? 12.66494 -24.33828 18.84984  1.000 25.77129  ? 249 ILE A O   1 
ATOM   1945 C CB  . ILE A 1 249 ? 15.42405 -24.46276 17.12013  1.000 21.65787  ? 249 ILE A CB  1 
ATOM   1946 C CG1 . ILE A 1 249 ? 16.72614 -23.66646 16.98678  1.000 25.40905  ? 249 ILE A CG1 1 
ATOM   1947 C CG2 . ILE A 1 249 ? 14.29628 -23.82865 16.32969  1.000 23.06931  ? 249 ILE A CG2 1 
ATOM   1948 C CD1 . ILE A 1 249 ? 17.51469 -24.07230 15.78623  1.000 28.04306  ? 249 ILE A CD1 1 
ATOM   1949 N N   . LEU A 1 250 ? 13.45090 -26.43432 18.77378  1.000 20.64562  ? 250 LEU A N   1 
ATOM   1950 C CA  . LEU A 1 250 ? 12.13500 -27.02791 18.95709  1.000 20.80169  ? 250 LEU A CA  1 
ATOM   1951 C C   . LEU A 1 250 ? 11.66205 -26.98663 20.40402  1.000 30.99745  ? 250 LEU A C   1 
ATOM   1952 O O   . LEU A 1 250 ? 10.61699 -27.57055 20.71717  1.000 25.42487  ? 250 LEU A O   1 
ATOM   1953 C CB  . LEU A 1 250 ? 12.14805 -28.47300 18.48090  1.000 19.65323  ? 250 LEU A CB  1 
ATOM   1954 C CG  . LEU A 1 250 ? 12.25009 -28.68469 16.97560  1.000 17.06587  ? 250 LEU A CG  1 
ATOM   1955 C CD1 . LEU A 1 250 ? 12.64690 -30.06899 16.70838  1.000 17.73028  ? 250 LEU A CD1 1 
ATOM   1956 C CD2 . LEU A 1 250 ? 10.90298 -28.39397 16.32069  1.000 16.80831  ? 250 LEU A CD2 1 
ATOM   1957 N N   . GLY A 1 251 ? 12.41385 -26.32417 21.27639  1.000 30.99370  ? 251 GLY A N   1 
ATOM   1958 C CA  . GLY A 1 251 ? 12.10600 -26.23569 22.68384  1.000 32.65173  ? 251 GLY A CA  1 
ATOM   1959 C C   . GLY A 1 251 ? 10.72987 -25.68172 22.98678  1.000 29.84249  ? 251 GLY A C   1 
ATOM   1960 O O   . GLY A 1 251 ? 9.94818  -26.30343 23.70669  1.000 29.27142  ? 251 GLY A O   1 
ATOM   1961 N N   . PRO A 1 252 ? 10.40929 -24.49244 22.46439  1.000 25.54299  ? 252 PRO A N   1 
ATOM   1962 C CA  . PRO A 1 252 ? 9.08484  -23.91302 22.74478  1.000 22.17416  ? 252 PRO A CA  1 
ATOM   1963 C C   . PRO A 1 252 ? 7.91989  -24.80711 22.33888  1.000 24.87838  ? 252 PRO A C   1 
ATOM   1964 O O   . PRO A 1 252 ? 6.93917  -24.91773 23.08494  1.000 27.40383  ? 252 PRO A O   1 
ATOM   1965 C CB  . PRO A 1 252 ? 9.11212  -22.60541 21.93938  1.000 29.10133  ? 252 PRO A CB  1 
ATOM   1966 C CG  . PRO A 1 252 ? 10.53330 -22.23181 21.89514  1.000 32.36087  ? 252 PRO A CG  1 
ATOM   1967 C CD  . PRO A 1 252 ? 11.30951 -23.52165 21.81513  1.000 29.05760  ? 252 PRO A CD  1 
ATOM   1968 N N   . LEU A 1 253 ? 8.01068  -25.47737 21.18621  1.000 21.38833  ? 253 LEU A N   1 
ATOM   1969 C CA  . LEU A 1 253 ? 6.90812  -26.32975 20.73896  1.000 18.22577  ? 253 LEU A CA  1 
ATOM   1970 C C   . LEU A 1 253 ? 6.80508  -27.59739 21.58278  1.000 22.22843  ? 253 LEU A C   1 
ATOM   1971 O O   . LEU A 1 253 ? 5.69386  -28.06980 21.86311  1.000 22.20836  ? 253 LEU A O   1 
ATOM   1972 C CB  . LEU A 1 253 ? 7.08561  -26.69078 19.25487  1.000 19.06208  ? 253 LEU A CB  1 
ATOM   1973 C CG  . LEU A 1 253 ? 6.83960  -25.57800 18.23274  1.000 17.07697  ? 253 LEU A CG  1 
ATOM   1974 C CD1 . LEU A 1 253 ? 7.30240  -25.98839 16.82993  1.000 19.00309  ? 253 LEU A CD1 1 
ATOM   1975 C CD2 . LEU A 1 253 ? 5.34370  -25.24027 18.20478  1.000 13.94943  ? 253 LEU A CD2 1 
ATOM   1976 N N   . SER A 1 254 ? 7.94963  -28.19979 21.93835  1.000 21.71809  ? 254 SER A N   1 
ATOM   1977 C CA  . SER A 1 254 ? 7.94988  -29.29929 22.90338  1.000 27.46621  ? 254 SER A CA  1 
ATOM   1978 C C   . SER A 1 254 ? 7.28096  -28.88353 24.20902  1.000 24.75193  ? 254 SER A C   1 
ATOM   1979 O O   . SER A 1 254 ? 6.49561  -29.64461 24.78344  1.000 25.58361  ? 254 SER A O   1 
ATOM   1980 C CB  . SER A 1 254 ? 9.38695  -29.76118 23.17067  1.000 26.08802  ? 254 SER A CB  1 
ATOM   1981 O OG  . SER A 1 254 ? 9.38903  -30.95189 23.93222  1.000 29.06937  ? 254 SER A OG  1 
ATOM   1982 N N   . ALA A 1 255 ? 7.57095  -27.66559 24.67744  1.000 30.42273  ? 255 ALA A N   1 
ATOM   1983 C CA  . ALA A 1 255 ? 7.02693  -27.16809 25.94133  1.000 28.70219  ? 255 ALA A CA  1 
ATOM   1984 C C   . ALA A 1 255 ? 5.51630  -26.96808 25.87414  1.000 26.96944  ? 255 ALA A C   1 
ATOM   1985 O O   . ALA A 1 255 ? 4.79200  -27.33378 26.80563  1.000 29.00346  ? 255 ALA A O   1 
ATOM   1986 C CB  . ALA A 1 255 ? 7.70993  -25.85389 26.31246  1.000 30.44074  ? 255 ALA A CB  1 
ATOM   1987 N N   . GLN A 1 256 ? 5.02611  -26.33747 24.80215  1.000 31.80143  ? 256 GLN A N   1 
ATOM   1988 C CA  . GLN A 1 256 ? 3.58773  -26.12560 24.65664  1.000 23.03450  ? 256 GLN A CA  1 
ATOM   1989 C C   . GLN A 1 256 ? 2.81741  -27.43794 24.59240  1.000 30.93372  ? 256 GLN A C   1 
ATOM   1990 O O   . GLN A 1 256 ? 1.71389  -27.54239 25.14277  1.000 32.55526  ? 256 GLN A O   1 
ATOM   1991 C CB  . GLN A 1 256 ? 3.29726  -25.29809 23.40484  1.000 29.39018  ? 256 GLN A CB  1 
ATOM   1992 C CG  . GLN A 1 256 ? 1.81883  -25.13630 23.12023  1.000 36.94954  ? 256 GLN A CG  1 
ATOM   1993 C CD  . GLN A 1 256 ? 1.55459  -24.34490 21.85554  1.000 28.19271  ? 256 GLN A CD  1 
ATOM   1994 O OE1 . GLN A 1 256 ? 2.47640  -23.80547 21.24792  1.000 40.83757  ? 256 GLN A OE1 1 
ATOM   1995 N NE2 . GLN A 1 256 ? 0.28361  -24.25778 21.45847  1.000 26.97150  ? 256 GLN A NE2 1 
ATOM   1996 N N   . THR A 1 257 ? 3.35621  -28.44029 23.90750  1.000 20.60880  ? 257 THR A N   1 
ATOM   1997 C CA  . THR A 1 257 ? 2.61313  -29.67410 23.68337  1.000 18.79626  ? 257 THR A CA  1 
ATOM   1998 C C   . THR A 1 257 ? 2.90653  -30.76482 24.70574  1.000 22.65933  ? 257 THR A C   1 
ATOM   1999 O O   . THR A 1 257 ? 2.22164  -31.78837 24.67900  1.000 25.85765  ? 257 THR A O   1 
ATOM   2000 C CB  . THR A 1 257 ? 2.91199  -30.28948 22.31823  1.000 22.19551  ? 257 THR A CB  1 
ATOM   2001 O OG1 . THR A 1 257 ? 4.30977  -30.64972 22.24973  1.000 22.99683  ? 257 THR A OG1 1 
ATOM   2002 C CG2 . THR A 1 257 ? 2.55607  -29.29867 21.20436  1.000 22.26808  ? 257 THR A CG2 1 
ATOM   2003 N N   . GLY A 1 258 ? 3.91833  -30.59276 25.55008  1.000 28.14788  ? 258 GLY A N   1 
ATOM   2004 C CA  . GLY A 1 258 ? 4.32146  -31.65227 26.45371  1.000 33.52218  ? 258 GLY A CA  1 
ATOM   2005 C C   . GLY A 1 258 ? 4.93644  -32.87678 25.81148  1.000 36.66756  ? 258 GLY A C   1 
ATOM   2006 O O   . GLY A 1 258 ? 5.05181  -33.90561 26.46375  1.000 27.41409  ? 258 GLY A O   1 
ATOM   2007 N N   . ILE A 1 259 ? 5.36237  -32.80487 24.55722  1.000 26.66558  ? 259 ILE A N   1 
ATOM   2008 C CA  . ILE A 1 259 ? 6.00562  -33.93641 23.90178  1.000 25.50597  ? 259 ILE A CA  1 
ATOM   2009 C C   . ILE A 1 259 ? 7.48081  -33.60391 23.77910  1.000 36.96070  ? 259 ILE A C   1 
ATOM   2010 O O   . ILE A 1 259 ? 7.83904  -32.58247 23.17715  1.000 25.39722  ? 259 ILE A O   1 
ATOM   2011 C CB  . ILE A 1 259 ? 5.38287  -34.23274 22.53613  1.000 21.79636  ? 259 ILE A CB  1 
ATOM   2012 C CG1 . ILE A 1 259 ? 3.92353  -34.59328 22.73829  1.000 24.09599  ? 259 ILE A CG1 1 
ATOM   2013 C CG2 . ILE A 1 259 ? 6.08667  -35.40292 21.82564  1.000 22.24689  ? 259 ILE A CG2 1 
ATOM   2014 C CD1 . ILE A 1 259 ? 3.18997  -34.70513 21.45153  1.000 27.83152  ? 259 ILE A CD1 1 
ATOM   2015 N N   . ALA A 1 260 ? 8.33009  -34.43294 24.39816  1.000 26.33928  ? 260 ALA A N   1 
ATOM   2016 C CA  . ALA A 1 260 ? 9.76431  -34.21251 24.32278  1.000 28.78759  ? 260 ALA A CA  1 
ATOM   2017 C C   . ALA A 1 260 ? 10.22046 -34.32201 22.87526  1.000 21.50215  ? 260 ALA A C   1 
ATOM   2018 O O   . ALA A 1 260 ? 9.68522  -35.12606 22.09944  1.000 21.25127  ? 260 ALA A O   1 
ATOM   2019 C CB  . ALA A 1 260 ? 10.50701 -35.23433 25.18950  1.000 28.12787  ? 260 ALA A CB  1 
ATOM   2020 N N   . VAL A 1 261 ? 11.25038 -33.53055 22.52193  1.000 24.92343  ? 261 VAL A N   1 
ATOM   2021 C CA  . VAL A 1 261 ? 11.74608 -33.55593 21.14219  1.000 21.93546  ? 261 VAL A CA  1 
ATOM   2022 C C   . VAL A 1 261 ? 12.12134 -34.96324 20.72904  1.000 21.59446  ? 261 VAL A C   1 
ATOM   2023 O O   . VAL A 1 261 ? 11.79705 -35.41800 19.62478  1.000 22.58726  ? 261 VAL A O   1 
ATOM   2024 C CB  . VAL A 1 261 ? 12.93943 -32.60733 20.95964  1.000 22.50671  ? 261 VAL A CB  1 
ATOM   2025 C CG1 . VAL A 1 261 ? 13.50951 -32.78624 19.54197  1.000 18.85573  ? 261 VAL A CG1 1 
ATOM   2026 C CG2 . VAL A 1 261 ? 12.53407 -31.15431 21.22688  1.000 26.84485  ? 261 VAL A CG2 1 
ATOM   2027 N N   . LEU A 1 262 ? 12.84906 -35.67425 21.60135  1.000 24.44892  ? 262 LEU A N   1 
ATOM   2028 C CA  . LEU A 1 262 ? 13.29251 -37.01105 21.24041  1.000 30.67320  ? 262 LEU A CA  1 
ATOM   2029 C C   . LEU A 1 262 ? 12.11525 -37.97408 21.13671  1.000 25.93215  ? 262 LEU A C   1 
ATOM   2030 O O   . LEU A 1 262 ? 12.18293 -38.95807 20.38970  1.000 21.95698  ? 262 LEU A O   1 
ATOM   2031 C CB  . LEU A 1 262 ? 14.33358 -37.47303 22.26448  1.000 24.91283  ? 262 LEU A CB  1 
ATOM   2032 C CG  . LEU A 1 262 ? 15.64363 -36.66888 22.07101  1.000 38.10816  ? 262 LEU A CG  1 
ATOM   2033 C CD1 . LEU A 1 262 ? 16.69201 -36.95758 23.15584  1.000 32.11083  ? 262 LEU A CD1 1 
ATOM   2034 C CD2 . LEU A 1 262 ? 16.25608 -36.88938 20.69071  1.000 25.31744  ? 262 LEU A CD2 1 
ATOM   2035 N N   . ASP A 1 263 ? 11.01786 -37.69848 21.85073  1.000 24.15043  ? 263 ASP A N   1 
ATOM   2036 C CA  . ASP A 1 263 ? 9.82035  -38.50917 21.67435  1.000 27.56276  ? 263 ASP A CA  1 
ATOM   2037 C C   . ASP A 1 263 ? 9.17717  -38.26087 20.31696  1.000 22.71733  ? 263 ASP A C   1 
ATOM   2038 O O   . ASP A 1 263 ? 8.77409  -39.21038 19.63252  1.000 22.42252  ? 263 ASP A O   1 
ATOM   2039 C CB  . ASP A 1 263 ? 8.80354  -38.23384 22.78135  1.000 27.09323  ? 263 ASP A CB  1 
ATOM   2040 C CG  . ASP A 1 263 ? 9.22404  -38.82163 24.10414  1.000 46.47696  ? 263 ASP A CG  1 
ATOM   2041 O OD1 . ASP A 1 263 ? 10.34010 -39.38842 24.16460  1.000 41.10204  ? 263 ASP A OD1 1 
ATOM   2042 O OD2 . ASP A 1 263 ? 8.43345  -38.74559 25.07038  1.000 43.17753  ? 263 ASP A OD2 1 
ATOM   2043 N N   . MET A 1 264 ? 9.03031  -36.98255 19.92933  1.000 16.62342  ? 264 MET A N   1 
ATOM   2044 C CA  . MET A 1 264 ? 8.58921  -36.70063 18.55947  1.000 21.14519  ? 264 MET A CA  1 
ATOM   2045 C C   . MET A 1 264 ? 9.48280  -37.38173 17.53574  1.000 20.17970  ? 264 MET A C   1 
ATOM   2046 O O   . MET A 1 264 ? 9.01796  -37.81480 16.47521  1.000 18.23776  ? 264 MET A O   1 
ATOM   2047 C CB  . MET A 1 264 ? 8.62082  -35.20705 18.27317  1.000 15.98893  ? 264 MET A CB  1 
ATOM   2048 C CG  . MET A 1 264 ? 7.60199  -34.74046 17.24661  1.000 16.86048  ? 264 MET A CG  1 
ATOM   2049 S SD  . MET A 1 264 ? 5.90789  -35.45575 17.18296  1.000 16.72140  ? 264 MET A SD  1 
ATOM   2050 C CE  . MET A 1 264 ? 5.21875  -34.11681 18.05256  1.000 17.72766  ? 264 MET A CE  1 
ATOM   2051 N N   . CYS A 1 265 ? 10.78533 -37.48441 17.82302  1.000 20.23040  ? 265 CYS A N   1 
ATOM   2052 C CA  . CYS A 1 265 ? 11.67580 -38.13475 16.86672  1.000 20.16172  ? 265 CYS A CA  1 
ATOM   2053 C C   . CYS A 1 265 ? 11.33505 -39.60783 16.71358  1.000 21.80767  ? 265 CYS A C   1 
ATOM   2054 O O   . CYS A 1 265 ? 11.40272 -40.16267 15.61085  1.000 21.44579  ? 265 CYS A O   1 
ATOM   2055 C CB  . CYS A 1 265 ? 13.12951 -37.96339 17.31551  1.000 19.77583  ? 265 CYS A CB  1 
ATOM   2056 S SG  . CYS A 1 265 ? 13.78642 -36.27244 17.09700  1.000 22.32431  ? 265 CYS A SG  1 
ATOM   2057 N N   . ALA A 1 266 ? 10.94421 -40.26048 17.81307  1.000 18.97393  ? 266 ALA A N   1 
ATOM   2058 C CA  . ALA A 1 266 ? 10.49268 -41.64837 17.72036  1.000 22.07029  ? 266 ALA A CA  1 
ATOM   2059 C C   . ALA A 1 266 ? 9.21801  -41.78032 16.88979  1.000 29.50744  ? 266 ALA A C   1 
ATOM   2060 O O   . ALA A 1 266 ? 9.04454  -42.77303 16.16577  1.000 26.65498  ? 266 ALA A O   1 
ATOM   2061 C CB  . ALA A 1 266 ? 10.29392 -42.22833 19.11931  1.000 25.55069  ? 266 ALA A CB  1 
ATOM   2062 N N   . SER A 1 267 ? 8.29932  -40.80194 16.98975  1.000 21.42744  ? 267 SER A N   1 
ATOM   2063 C CA  . SER A 1 267 ? 7.15139  -40.78361 16.08784  1.000 21.26944  ? 267 SER A CA  1 
ATOM   2064 C C   . SER A 1 267 ? 7.59491  -40.71922 14.63408  1.000 19.46721  ? 267 SER A C   1 
ATOM   2065 O O   . SER A 1 267 ? 7.09965  -41.47106 13.78943  1.000 22.58718  ? 267 SER A O   1 
ATOM   2066 C CB  . SER A 1 267 ? 6.24704  -39.58662 16.39437  1.000 31.34007  ? 267 SER A CB  1 
ATOM   2067 O OG  . SER A 1 267 ? 5.56901  -39.77688 17.60571  1.000 38.85342  ? 267 SER A OG  1 
ATOM   2068 N N   . LEU A 1 268 ? 8.51723  -39.78730 14.32556  1.000 22.12663  ? 268 LEU A N   1 
ATOM   2069 C CA  . LEU A 1 268 ? 8.97784  -39.61454 12.95331  1.000 21.44969  ? 268 LEU A CA  1 
ATOM   2070 C C   . LEU A 1 268 ? 9.67189  -40.87775 12.45700  1.000 14.99174  ? 268 LEU A C   1 
ATOM   2071 O O   . LEU A 1 268 ? 9.41713  -41.33040 11.33977  1.000 20.44838  ? 268 LEU A O   1 
ATOM   2072 C CB  . LEU A 1 268 ? 9.90854  -38.39948 12.85875  1.000 19.77845  ? 268 LEU A CB  1 
ATOM   2073 C CG  . LEU A 1 268 ? 10.46249 -38.10183 11.45901  1.000 16.96713  ? 268 LEU A CG  1 
ATOM   2074 C CD1 . LEU A 1 268 ? 9.32808  -37.99913 10.43609  1.000 16.87089  ? 268 LEU A CD1 1 
ATOM   2075 C CD2 . LEU A 1 268 ? 11.27617 -36.81895 11.47871  1.000 18.87473  ? 268 LEU A CD2 1 
ATOM   2076 N N   . LYS A 1 269 ? 10.47214 -41.52333 13.31569  1.000 19.02848  ? 269 LYS A N   1 
ATOM   2077 C CA  . LYS A 1 269 ? 11.12770 -42.76848 12.90869  1.000 19.56354  ? 269 LYS A CA  1 
ATOM   2078 C C   . LYS A 1 269 ? 10.10206 -43.82128 12.49739  1.000 21.87456  ? 269 LYS A C   1 
ATOM   2079 O O   . LYS A 1 269 ? 10.23444 -44.46963 11.44503  1.000 21.55670  ? 269 LYS A O   1 
ATOM   2080 C CB  . LYS A 1 269 ? 12.01712 -43.27580 14.04678  1.000 27.62594  ? 269 LYS A CB  1 
ATOM   2081 C CG  . LYS A 1 269 ? 12.62162 -44.67433 13.83515  1.000 34.85034  ? 269 LYS A CG  1 
ATOM   2082 C CD  . LYS A 1 269 ? 13.20091 -45.18855 15.15553  1.000 41.54489  ? 269 LYS A CD  1 
ATOM   2083 C CE  . LYS A 1 269 ? 14.41574 -44.35812 15.57810  1.000 34.40135  ? 269 LYS A CE  1 
ATOM   2084 N NZ  . LYS A 1 269 ? 15.02589 -44.80214 16.86474  1.000 46.12501  ? 269 LYS A NZ  1 
ATOM   2085 N N   . GLU A 1 270 ? 9.04736  -43.98625 13.31863  1.000 21.58772  ? 270 GLU A N   1 
ATOM   2086 C CA  . GLU A 1 270 ? 7.96709  -44.90901 12.98108  1.000 22.79800  ? 270 GLU A CA  1 
ATOM   2087 C C   . GLU A 1 270 ? 7.29144  -44.53165 11.66859  1.000 32.21151  ? 270 GLU A C   1 
ATOM   2088 O O   . GLU A 1 270 ? 7.03888  -45.40072 10.82485  1.000 27.65094  ? 270 GLU A O   1 
ATOM   2089 C CB  . GLU A 1 270 ? 6.95011  -44.94611 14.12234  1.000 28.36079  ? 270 GLU A CB  1 
ATOM   2090 C CG  . GLU A 1 270 ? 6.02433  -46.14232 14.13072  1.000 32.49224  ? 270 GLU A CG  1 
ATOM   2091 C CD  . GLU A 1 270 ? 5.27296  -46.26915 15.46084  1.000 53.87802  ? 270 GLU A CD  1 
ATOM   2092 O OE1 . GLU A 1 270 ? 5.77481  -46.97167 16.37263  1.000 48.11186  ? 270 GLU A OE1 1 
ATOM   2093 O OE2 . GLU A 1 270 ? 4.21107  -45.60755 15.61049  1.000 46.80197  ? 270 GLU A OE2 1 
ATOM   2094 N N   . LEU A 1 271 ? 7.00403  -43.23581 11.46790  1.000 22.75251  ? 271 LEU A N   1 
ATOM   2095 C CA  . LEU A 1 271 ? 6.39701  -42.80398 10.20875  1.000 23.71318  ? 271 LEU A CA  1 
ATOM   2096 C C   . LEU A 1 271 ? 7.30614  -43.10381 9.02056   1.000 22.45447  ? 271 LEU A C   1 
ATOM   2097 O O   . LEU A 1 271 ? 6.83059  -43.47737 7.93691   1.000 28.19262  ? 271 LEU A O   1 
ATOM   2098 C CB  . LEU A 1 271 ? 6.08685  -41.31039 10.27765  1.000 23.19825  ? 271 LEU A CB  1 
ATOM   2099 C CG  . LEU A 1 271 ? 4.86390  -40.89492 11.09633  1.000 23.92820  ? 271 LEU A CG  1 
ATOM   2100 C CD1 . LEU A 1 271 ? 4.90205  -39.36263 11.27342  1.000 18.78166  ? 271 LEU A CD1 1 
ATOM   2101 C CD2 . LEU A 1 271 ? 3.56846  -41.39447 10.43135  1.000 27.89037  ? 271 LEU A CD2 1 
ATOM   2102 N N   . LEU A 1 272 ? 8.61620  -42.91930 9.19659   1.000 26.61299  ? 272 LEU A N   1 
ATOM   2103 C CA  . LEU A 1 272 ? 9.55975  -43.19519 8.11325   1.000 24.01967  ? 272 LEU A CA  1 
ATOM   2104 C C   . LEU A 1 272 ? 9.59143  -44.67870 7.78356   1.000 25.68954  ? 272 LEU A C   1 
ATOM   2105 O O   . LEU A 1 272 ? 9.62255  -45.05355 6.60316   1.000 26.92131  ? 272 LEU A O   1 
ATOM   2106 C CB  . LEU A 1 272 ? 10.96503 -42.68796 8.46800   1.000 22.49322  ? 272 LEU A CB  1 
ATOM   2107 C CG  . LEU A 1 272 ? 11.04007 -41.15586 8.37496   1.000 28.48385  ? 272 LEU A CG  1 
ATOM   2108 C CD1 . LEU A 1 272 ? 12.39146 -40.56919 8.78498   1.000 21.20234  ? 272 LEU A CD1 1 
ATOM   2109 C CD2 . LEU A 1 272 ? 10.65182 -40.73753 6.96842   1.000 24.98820  ? 272 LEU A CD2 1 
ATOM   2110 N N   . GLN A 1 273 ? 9.54949  -45.52991 8.81632   1.000 27.42266  ? 273 GLN A N   1 
ATOM   2111 C CA  . GLN A 1 273 ? 9.69834  -46.97310 8.63629   1.000 30.01291  ? 273 GLN A CA  1 
ATOM   2112 C C   . GLN A 1 273 ? 8.41324  -47.65382 8.20366   1.000 35.31561  ? 273 GLN A C   1 
ATOM   2113 O O   . GLN A 1 273 ? 8.46597  -48.69788 7.54863   1.000 37.98219  ? 273 GLN A O   1 
ATOM   2114 C CB  . GLN A 1 273 ? 10.21467 -47.60334 9.92832   1.000 28.82723  ? 273 GLN A CB  1 
ATOM   2115 C CG  . GLN A 1 273 ? 11.64001 -47.18748 10.25266  1.000 32.23799  ? 273 GLN A CG  1 
ATOM   2116 C CD  . GLN A 1 273 ? 12.08258 -47.58580 11.64614  1.000 36.39386  ? 273 GLN A CD  1 
ATOM   2117 O OE1 . GLN A 1 273 ? 11.26761 -47.94032 12.49669  1.000 46.66863  ? 273 GLN A OE1 1 
ATOM   2118 N NE2 . GLN A 1 273 ? 13.38123 -47.52952 11.88523  1.000 38.82767  ? 273 GLN A NE2 1 
ATOM   2119 N N   . ASN A 1 274 ? 7.26116  -47.08792 8.54315   1.000 32.30667  ? 274 ASN A N   1 
ATOM   2120 C CA  . ASN A 1 274 ? 5.98872  -47.75386 8.34683   1.000 41.05729  ? 274 ASN A CA  1 
ATOM   2121 C C   . ASN A 1 274 ? 5.05909  -47.03699 7.38743   1.000 42.79517  ? 274 ASN A C   1 
ATOM   2122 O O   . ASN A 1 274 ? 4.03461  -47.61193 7.01176   1.000 38.32360  ? 274 ASN A O   1 
ATOM   2123 C CB  . ASN A 1 274 ? 5.28575  -47.91611 9.69698   1.000 39.11401  ? 274 ASN A CB  1 
ATOM   2124 C CG  . ASN A 1 274 ? 6.00021  -48.90361 10.57901  1.000 54.07383  ? 274 ASN A CG  1 
ATOM   2125 O OD1 . ASN A 1 274 ? 6.32678  -48.60331 11.73346  1.000 49.14366  ? 274 ASN A OD1 1 
ATOM   2126 N ND2 . ASN A 1 274 ? 6.29565  -50.08226 10.02615  1.000 53.84924  ? 274 ASN A ND2 1 
ATOM   2127 N N   . GLY A 1 275 ? 5.38350  -45.81629 6.97104   1.000 37.92930  ? 275 GLY A N   1 
ATOM   2128 C CA  . GLY A 1 275 ? 4.45491  -45.06179 6.17846   1.000 34.74787  ? 275 GLY A CA  1 
ATOM   2129 C C   . GLY A 1 275 ? 3.28862  -44.56264 7.01127   1.000 31.87411  ? 275 GLY A C   1 
ATOM   2130 O O   . GLY A 1 275 ? 3.31837  -44.49872 8.24034   1.000 27.12137  ? 275 GLY A O   1 
ATOM   2131 N N   . MET A 1 276 ? 2.22676  -44.20702 6.31218   1.000 35.53199  ? 276 MET A N   1 
ATOM   2132 C CA  . MET A 1 276 ? 1.14006  -43.52018 6.95940   1.000 34.94003  ? 276 MET A CA  1 
ATOM   2133 C C   . MET A 1 276 ? -0.10263 -44.39678 7.04809   1.000 40.46843  ? 276 MET A C   1 
ATOM   2134 O O   . MET A 1 276 ? -1.02781 -44.06536 7.79930   1.000 33.25784  ? 276 MET A O   1 
ATOM   2135 C CB  . MET A 1 276 ? 0.87800  -42.22161 6.18133   1.000 49.62396  ? 276 MET A CB  1 
ATOM   2136 C CG  . MET A 1 276 ? 1.28231  -40.97435 6.96024   1.000 38.99333  ? 276 MET A CG  1 
ATOM   2137 S SD  . MET A 1 276 ? 0.65608  -39.41410 6.33432   1.000 39.87438  ? 276 MET A SD  1 
ATOM   2138 C CE  . MET A 1 276 ? 2.21643  -38.51646 6.27469   1.000 27.40409  ? 276 MET A CE  1 
ATOM   2139 N N   . ASN A 1 277 ? -0.10219 -45.54124 6.35428   1.000 51.37076  ? 277 ASN A N   1 
ATOM   2140 C CA  . ASN A 1 277 ? -1.22476 -46.48723 6.31307   1.000 53.80130  ? 277 ASN A CA  1 
ATOM   2141 C C   . ASN A 1 277 ? -2.53003 -45.79057 5.95478   1.000 46.20941  ? 277 ASN A C   1 
ATOM   2142 O O   . ASN A 1 277 ? -3.54511 -45.91437 6.65041   1.000 47.15645  ? 277 ASN A O   1 
ATOM   2143 C CB  . ASN A 1 277 ? -1.36373 -47.27171 7.62383   1.000 53.14314  ? 277 ASN A CB  1 
ATOM   2144 C CG  . ASN A 1 277 ? -0.11234 -48.06954 7.97183   1.000 68.73278  ? 277 ASN A CG  1 
ATOM   2145 O OD1 . ASN A 1 277 ? 0.75738  -47.61219 8.72057   1.000 67.58303  ? 277 ASN A OD1 1 
ATOM   2146 N ND2 . ASN A 1 277 ? -0.02373 -49.28183 7.42609   1.000 80.80768  ? 277 ASN A ND2 1 
ATOM   2147 N N   . GLY A 1 278 ? -2.49249 -45.04717 4.84812   1.000 46.02020  ? 278 GLY A N   1 
ATOM   2148 C CA  . GLY A 1 278 ? -3.67359 -44.38521 4.32799   1.000 41.30270  ? 278 GLY A CA  1 
ATOM   2149 C C   . GLY A 1 278 ? -4.21002 -43.25374 5.17272   1.000 45.00244  ? 278 GLY A C   1 
ATOM   2150 O O   . GLY A 1 278 ? -5.33266 -42.80071 4.94012   1.000 39.28880  ? 278 GLY A O   1 
ATOM   2151 N N   . ARG A 1 279 ? -3.45817 -42.79728 6.16101   1.000 37.94223  ? 279 ARG A N   1 
ATOM   2152 C CA  . ARG A 1 279 ? -3.84225 -41.67051 6.99451   1.000 33.31931  ? 279 ARG A CA  1 
ATOM   2153 C C   . ARG A 1 279 ? -3.16755 -40.40133 6.49060   1.000 22.26586  ? 279 ARG A C   1 
ATOM   2154 O O   . ARG A 1 279 ? -2.23394 -40.45038 5.69665   1.000 34.16772  ? 279 ARG A O   1 
ATOM   2155 C CB  . ARG A 1 279 ? -3.49476 -41.97546 8.46157   1.000 30.86488  ? 279 ARG A CB  1 
ATOM   2156 C CG  . ARG A 1 279 ? -4.67780 -42.65034 9.17647   1.000 42.69838  ? 279 ARG A CG  1 
ATOM   2157 C CD  . ARG A 1 279 ? -4.35523 -43.42361 10.45038  1.000 46.67871  ? 279 ARG A CD  1 
ATOM   2158 N NE  . ARG A 1 279 ? -3.05666 -44.09058 10.38714  1.000 53.35403  ? 279 ARG A NE  1 
ATOM   2159 C CZ  . ARG A 1 279 ? -2.54622 -44.84085 11.35977  1.000 51.12249  ? 279 ARG A CZ  1 
ATOM   2160 N NH1 . ARG A 1 279 ? -3.18228 -45.00722 12.51179  1.000 48.71766  ? 279 ARG A NH1 1 
ATOM   2161 N NH2 . ARG A 1 279 ? -1.37304 -45.44683 11.16763  1.000 37.38359  ? 279 ARG A NH2 1 
ATOM   2162 N N   . THR A 1 280 ? -3.68215 -39.26066 6.93250   1.000 24.80164  ? 280 THR A N   1 
ATOM   2163 C CA  . THR A 1 280 ? -3.11422 -37.95795 6.60450   1.000 28.84338  ? 280 THR A CA  1 
ATOM   2164 C C   . THR A 1 280 ? -2.75347 -37.20070 7.87668   1.000 21.44623  ? 280 THR A C   1 
ATOM   2165 O O   . THR A 1 280 ? -3.28470 -37.45923 8.95602   1.000 19.03751  ? 280 THR A O   1 
ATOM   2166 C CB  . THR A 1 280 ? -4.08114 -37.10423 5.75919   1.000 24.87934  ? 280 THR A CB  1 
ATOM   2167 O OG1 . THR A 1 280 ? -5.33295 -36.94897 6.44511   1.000 25.83386  ? 280 THR A OG1 1 
ATOM   2168 C CG2 . THR A 1 280 ? -4.30567 -37.72365 4.38772   1.000 26.77787  ? 280 THR A CG2 1 
ATOM   2169 N N   . ILE A 1 281 ? -1.86128 -36.21781 7.73770   1.000 16.38716  ? 281 ILE A N   1 
ATOM   2170 C CA  . ILE A 1 281 ? -1.51913 -35.29691 8.81432   1.000 16.93436  ? 281 ILE A CA  1 
ATOM   2171 C C   . ILE A 1 281 ? -1.72092 -33.88288 8.28288   1.000 14.94492  ? 281 ILE A C   1 
ATOM   2172 O O   . ILE A 1 281 ? -1.15410 -33.53731 7.24480   1.000 18.08528  ? 281 ILE A O   1 
ATOM   2173 C CB  . ILE A 1 281 ? -0.06331 -35.51207 9.29179   1.000 17.54353  ? 281 ILE A CB  1 
ATOM   2174 C CG1 . ILE A 1 281 ? 0.14146  -36.96702 9.74913   1.000 19.18230  ? 281 ILE A CG1 1 
ATOM   2175 C CG2 . ILE A 1 281 ? 0.34266  -34.49565 10.33627  1.000 19.37685  ? 281 ILE A CG2 1 
ATOM   2176 C CD1 . ILE A 1 281 ? 1.54527  -37.30605 10.25184  1.000 16.11052  ? 281 ILE A CD1 1 
ATOM   2177 N N   . LEU A 1 282 ? -2.50806 -33.06457 8.98710   1.000 14.61947  ? 282 LEU A N   1 
ATOM   2178 C CA  . LEU A 1 282 ? -2.82802 -31.71140 8.51269   1.000 20.74990  ? 282 LEU A CA  1 
ATOM   2179 C C   . LEU A 1 282 ? -3.13573 -31.69831 7.01963   1.000 19.38225  ? 282 LEU A C   1 
ATOM   2180 O O   . LEU A 1 282 ? -2.65242 -30.84568 6.26708   1.000 19.22632  ? 282 LEU A O   1 
ATOM   2181 C CB  . LEU A 1 282 ? -1.67699 -30.76299 8.82101   1.000 17.43413  ? 282 LEU A CB  1 
ATOM   2182 C CG  . LEU A 1 282 ? -1.56415 -30.50779 10.31549  1.000 14.77514  ? 282 LEU A CG  1 
ATOM   2183 C CD1 . LEU A 1 282 ? -0.37195 -29.66115 10.64166  1.000 17.35080  ? 282 LEU A CD1 1 
ATOM   2184 C CD2 . LEU A 1 282 ? -2.85408 -29.82380 10.79718  1.000 13.82769  ? 282 LEU A CD2 1 
ATOM   2185 N N   . GLY A 1 283 ? -3.86755 -32.70526 6.57548   1.000 17.71244  ? 283 GLY A N   1 
ATOM   2186 C CA  . GLY A 1 283 ? -4.34257 -32.75716 5.21355   1.000 17.31083  ? 283 GLY A CA  1 
ATOM   2187 C C   . GLY A 1 283 ? -3.31713 -33.17449 4.19508   1.000 22.99118  ? 283 GLY A C   1 
ATOM   2188 O O   . GLY A 1 283 ? -3.57538 -33.03203 2.99743   1.000 30.18809  ? 283 GLY A O   1 
ATOM   2189 N N   . SER A 1 284 ? -2.16195 -33.67717 4.62463   1.000 14.86594  ? 284 SER A N   1 
ATOM   2190 C CA  . SER A 1 284 ? -1.13617 -34.16635 3.71834   1.000 16.37036  ? 284 SER A CA  1 
ATOM   2191 C C   . SER A 1 284 ? -0.92062 -35.66432 3.88063   1.000 19.10851  ? 284 SER A C   1 
ATOM   2192 O O   . SER A 1 284 ? -0.91325 -36.19440 4.99963   1.000 20.72126  ? 284 SER A O   1 
ATOM   2193 C CB  . SER A 1 284 ? 0.18215  -33.40514 3.94923   1.000 17.83319  ? 284 SER A CB  1 
ATOM   2194 O OG  . SER A 1 284 ? 1.21700  -33.92281 3.13090   1.000 21.69376  ? 284 SER A OG  1 
ATOM   2195 N N   . ALA A 1 285 ? -0.70196 -36.33848 2.75713   1.000 19.23602  ? 285 ALA A N   1 
ATOM   2196 C CA  . ALA A 1 285 ? -0.26395 -37.71863 2.81040   1.000 21.73113  ? 285 ALA A CA  1 
ATOM   2197 C C   . ALA A 1 285 ? 1.24561  -37.86614 2.71295   1.000 20.67861  ? 285 ALA A C   1 
ATOM   2198 O O   . ALA A 1 285 ? 1.73867  -38.99638 2.69469   1.000 26.34378  ? 285 ALA A O   1 
ATOM   2199 C CB  . ALA A 1 285 ? -0.93575 -38.52516 1.70706   1.000 21.65210  ? 285 ALA A CB  1 
ATOM   2200 N N   . LEU A 1 286 ? 1.98944  -36.76042 2.63234   1.000 22.69037  ? 286 LEU A N   1 
ATOM   2201 C CA  . LEU A 1 286 ? 3.44232  -36.75738 2.70999   1.000 19.69050  ? 286 LEU A CA  1 
ATOM   2202 C C   . LEU A 1 286 ? 3.86425  -36.00047 3.95763   1.000 16.22124  ? 286 LEU A C   1 
ATOM   2203 O O   . LEU A 1 286 ? 3.11080  -35.19767 4.49306   1.000 14.15423  ? 286 LEU A O   1 
ATOM   2204 C CB  . LEU A 1 286 ? 4.08383  -36.08987 1.48898   1.000 23.10257  ? 286 LEU A CB  1 
ATOM   2205 C CG  . LEU A 1 286 ? 3.64012  -36.58383 0.11546   1.000 28.85820  ? 286 LEU A CG  1 
ATOM   2206 C CD1 . LEU A 1 286 ? 4.27901  -35.75729 -0.97511  1.000 29.88591  ? 286 LEU A CD1 1 
ATOM   2207 C CD2 . LEU A 1 286 ? 4.00315  -38.04243 -0.01494  1.000 32.00843  ? 286 LEU A CD2 1 
ATOM   2208 N N   . LEU A 1 287 ? 5.07547  -36.26189 4.42136   1.000 14.32208  ? 287 LEU A N   1 
ATOM   2209 C CA  . LEU A 1 287 ? 5.65880  -35.55623 5.55187   1.000 14.04631  ? 287 LEU A CA  1 
ATOM   2210 C C   . LEU A 1 287 ? 6.14124  -34.19148 5.06740   1.000 16.72529  ? 287 LEU A C   1 
ATOM   2211 O O   . LEU A 1 287 ? 7.06348  -34.10541 4.26186   1.000 23.42331  ? 287 LEU A O   1 
ATOM   2212 C CB  . LEU A 1 287 ? 6.80932  -36.36675 6.16338   1.000 12.65720  ? 287 LEU A CB  1 
ATOM   2213 C CG  . LEU A 1 287 ? 6.36253  -37.75261 6.69630   1.000 15.09043  ? 287 LEU A CG  1 
ATOM   2214 C CD1 . LEU A 1 287 ? 7.57203  -38.58295 7.14315   1.000 22.78220  ? 287 LEU A CD1 1 
ATOM   2215 C CD2 . LEU A 1 287 ? 5.44180  -37.53665 7.86676   1.000 23.98047  ? 287 LEU A CD2 1 
ATOM   2216 N N   . GLU A 1 288 ? 5.52881  -33.13625 5.57760   1.000 14.89810  ? 288 GLU A N   1 
ATOM   2217 C CA  . GLU A 1 288 ? 5.76426  -31.78793 5.09125   1.000 13.50887  ? 288 GLU A CA  1 
ATOM   2218 C C   . GLU A 1 288 ? 7.00979  -31.14916 5.72266   1.000 12.93189  ? 288 GLU A C   1 
ATOM   2219 O O   . GLU A 1 288 ? 7.14882  -31.12203 6.94352   1.000 14.04045  ? 288 GLU A O   1 
ATOM   2220 C CB  . GLU A 1 288 ? 4.53524  -30.93850 5.37196   1.000 10.82728  ? 288 GLU A CB  1 
ATOM   2221 C CG  . GLU A 1 288 ? 4.79399  -29.46783 5.12540   1.000 23.95549  ? 288 GLU A CG  1 
ATOM   2222 C CD  . GLU A 1 288 ? 4.86771  -29.14178 3.62098   1.000 37.37864  ? 288 GLU A CD  1 
ATOM   2223 O OE1 . GLU A 1 288 ? 3.94268  -29.59886 2.87471   1.000 29.50680  ? 288 GLU A OE1 1 
ATOM   2224 O OE2 . GLU A 1 288 ? 5.85075  -28.44489 3.21090   1.000 16.19121  ? 288 GLU A OE2 1 
ATOM   2225 N N   . ASP A 1 289 ? 7.89188  -30.54235 4.89974   1.000 14.45795  ? 289 ASP A N   1 
ATOM   2226 C CA  . ASP A 1 289 ? 9.12628  -29.99131 5.46988   1.000 10.45733  ? 289 ASP A CA  1 
ATOM   2227 C C   . ASP A 1 289 ? 9.37893  -28.51929 5.13352   1.000 12.37926  ? 289 ASP A C   1 
ATOM   2228 O O   . ASP A 1 289 ? 10.53831 -28.05169 5.30603   1.000 15.06767  ? 289 ASP A O   1 
ATOM   2229 C CB  . ASP A 1 289 ? 10.36009 -30.83077 5.06856   1.000 11.24692  ? 289 ASP A CB  1 
ATOM   2230 C CG  . ASP A 1 289 ? 10.85319 -30.56661 3.63723   1.000 19.31332  ? 289 ASP A CG  1 
ATOM   2231 O OD1 . ASP A 1 289 ? 10.09180 -30.05244 2.78442   1.000 14.87609  ? 289 ASP A OD1 1 
ATOM   2232 O OD2 . ASP A 1 289 ? 12.01840 -30.94298 3.32865   1.000 15.57413  ? 289 ASP A OD2 1 
ATOM   2233 N N   . GLU A 1 290 ? 8.35385  -27.76726 4.72570   1.000 13.25412  ? 290 GLU A N   1 
ATOM   2234 C CA  . GLU A 1 290 ? 8.52997  -26.34600 4.44340   1.000 13.27351  ? 290 GLU A CA  1 
ATOM   2235 C C   . GLU A 1 290 ? 7.78561  -25.45743 5.43646   1.000 13.01435  ? 290 GLU A C   1 
ATOM   2236 O O   . GLU A 1 290 ? 7.38800  -24.33685 5.10493   1.000 12.09943  ? 290 GLU A O   1 
ATOM   2237 C CB  . GLU A 1 290 ? 8.16395  -26.04086 2.97590   1.000 14.58229  ? 290 GLU A CB  1 
ATOM   2238 C CG  . GLU A 1 290 ? 9.19474  -26.73297 2.03199   1.000 16.48587  ? 290 GLU A CG  1 
ATOM   2239 C CD  . GLU A 1 290 ? 9.37887  -26.10895 0.64041   1.000 19.67921  ? 290 GLU A CD  1 
ATOM   2240 O OE1 . GLU A 1 290 ? 8.61742  -25.15649 0.27562   1.000 13.29109  ? 290 GLU A OE1 1 
ATOM   2241 O OE2 . GLU A 1 290 ? 10.28898 -26.61732 -0.10935  1.000 17.35485  ? 290 GLU A OE2 1 
ATOM   2242 N N   . PHE A 1 291 ? 7.69309  -25.91484 6.69426   1.000 10.19782  ? 291 PHE A N   1 
ATOM   2243 C CA  . PHE A 1 291 ? 7.33434  -25.07138 7.82848   1.000 14.66219  ? 291 PHE A CA  1 
ATOM   2244 C C   . PHE A 1 291 ? 8.46063  -25.10891 8.85030   1.000 13.46527  ? 291 PHE A C   1 
ATOM   2245 O O   . PHE A 1 291 ? 8.79735  -26.18020 9.35986   1.000 12.71131  ? 291 PHE A O   1 
ATOM   2246 C CB  . PHE A 1 291 ? 6.04940  -25.57189 8.48752   1.000 11.88602  ? 291 PHE A CB  1 
ATOM   2247 C CG  . PHE A 1 291 ? 4.83030  -25.43841 7.63784   1.000 12.55023  ? 291 PHE A CG  1 
ATOM   2248 C CD1 . PHE A 1 291 ? 4.13900  -24.22571 7.55717   1.000 12.48405  ? 291 PHE A CD1 1 
ATOM   2249 C CD2 . PHE A 1 291 ? 4.32591  -26.53779 6.99058   1.000 18.64513  ? 291 PHE A CD2 1 
ATOM   2250 C CE1 . PHE A 1 291 ? 2.97997  -24.12345 6.80814   1.000 16.86166  ? 291 PHE A CE1 1 
ATOM   2251 C CE2 . PHE A 1 291 ? 3.15874  -26.44276 6.22913   1.000 18.46280  ? 291 PHE A CE2 1 
ATOM   2252 C CZ  . PHE A 1 291 ? 2.49510  -25.21577 6.13076   1.000 18.68490  ? 291 PHE A CZ  1 
ATOM   2253 N N   . THR A 1 292 ? 9.03013  -23.94776 9.17582   1.000 11.02275  ? 292 THR A N   1 
ATOM   2254 C CA  . THR A 1 292 ? 10.02888 -23.91284 10.24215  1.000 10.94608  ? 292 THR A CA  1 
ATOM   2255 C C   . THR A 1 292 ? 9.36109  -23.92031 11.60860  1.000 11.01055  ? 292 THR A C   1 
ATOM   2256 O O   . THR A 1 292 ? 8.15408  -23.64542 11.73932  1.000 11.42846  ? 292 THR A O   1 
ATOM   2257 C CB  . THR A 1 292 ? 10.88556 -22.65450 10.14045  1.000 16.76828  ? 292 THR A CB  1 
ATOM   2258 O OG1 . THR A 1 292 ? 10.06835 -21.50952 10.39690  1.000 14.45809  ? 292 THR A OG1 1 
ATOM   2259 C CG2 . THR A 1 292 ? 11.55122 -22.54007 8.75086   1.000 12.64275  ? 292 THR A CG2 1 
ATOM   2260 N N   . PRO A 1 293 ? 10.12994 -24.15953 12.65664  1.000 12.40456  ? 293 PRO A N   1 
ATOM   2261 C CA  . PRO A 1 293 ? 9.56817  -24.00321 14.00267  1.000 13.78616  ? 293 PRO A CA  1 
ATOM   2262 C C   . PRO A 1 293 ? 8.95417  -22.63135 14.22175  1.000 18.58379  ? 293 PRO A C   1 
ATOM   2263 O O   . PRO A 1 293 ? 7.87961  -22.50318 14.83131  1.000 15.34792  ? 293 PRO A O   1 
ATOM   2264 C CB  . PRO A 1 293 ? 10.78766 -24.25887 14.89247  1.000 20.48137  ? 293 PRO A CB  1 
ATOM   2265 C CG  . PRO A 1 293 ? 11.58902 -25.24681 14.11734  1.000 22.41874  ? 293 PRO A CG  1 
ATOM   2266 C CD  . PRO A 1 293 ? 11.44460 -24.84928 12.67852  1.000 14.00034  ? 293 PRO A CD  1 
ATOM   2267 N N   . PHE A 1 294 ? 9.58483  -21.59348 13.67943  1.000 15.37633  ? 294 PHE A N   1 
ATOM   2268 C CA  . PHE A 1 294 ? 9.03173  -20.25507 13.81107  1.000 13.73636  ? 294 PHE A CA  1 
ATOM   2269 C C   . PHE A 1 294 ? 7.72064  -20.12935 13.05032  1.000 15.20993  ? 294 PHE A C   1 
ATOM   2270 O O   . PHE A 1 294 ? 6.75403  -19.51922 13.54043  1.000 17.15509  ? 294 PHE A O   1 
ATOM   2271 C CB  . PHE A 1 294 ? 10.04558 -19.24391 13.28760  1.000 19.95411  ? 294 PHE A CB  1 
ATOM   2272 C CG  . PHE A 1 294 ? 9.52239  -17.85366 13.20897  1.000 26.84632  ? 294 PHE A CG  1 
ATOM   2273 C CD1 . PHE A 1 294 ? 8.80133  -17.41362 12.09380  1.000 37.13008  ? 294 PHE A CD1 1 
ATOM   2274 C CD2 . PHE A 1 294 ? 9.76413  -16.95685 14.23272  1.000 34.63977  ? 294 PHE A CD2 1 
ATOM   2275 C CE1 . PHE A 1 294 ? 8.32274  -16.10908 12.02141  1.000 29.29522  ? 294 PHE A CE1 1 
ATOM   2276 C CE2 . PHE A 1 294 ? 9.28768  -15.66015 14.15422  1.000 34.96934  ? 294 PHE A CE2 1 
ATOM   2277 C CZ  . PHE A 1 294 ? 8.56438  -15.24392 13.04715  1.000 30.58240  ? 294 PHE A CZ  1 
ATOM   2278 N N   . ASP A 1 295 ? 7.66242  -20.67607 11.84039  1.000 11.61908  ? 295 ASP A N   1 
ATOM   2279 C CA  . ASP A 1 295 ? 6.39808  -20.62785 11.10498  1.000 15.14287  ? 295 ASP A CA  1 
ATOM   2280 C C   . ASP A 1 295 ? 5.25445  -21.21935 11.93053  1.000 16.00552  ? 295 ASP A C   1 
ATOM   2281 O O   . ASP A 1 295 ? 4.11240  -20.74199 11.86590  1.000 15.80960  ? 295 ASP A O   1 
ATOM   2282 C CB  . ASP A 1 295 ? 6.51621  -21.39496 9.79651   1.000 11.87987  ? 295 ASP A CB  1 
ATOM   2283 C CG  . ASP A 1 295 ? 7.52125  -20.77995 8.84492   1.000 16.32567  ? 295 ASP A CG  1 
ATOM   2284 O OD1 . ASP A 1 295 ? 7.83396  -19.57019 8.97677   1.000 18.08476  ? 295 ASP A OD1 1 
ATOM   2285 O OD2 . ASP A 1 295 ? 7.95832  -21.50900 7.93618   1.000 13.38065  ? 295 ASP A OD2 1 
ATOM   2286 N N   . VAL A 1 296 ? 5.52405  -22.31819 12.64140  1.000 13.49467  ? 296 VAL A N   1 
ATOM   2287 C CA  . VAL A 1 296 ? 4.45129  -22.99097 13.37143  1.000 14.98350  ? 296 VAL A CA  1 
ATOM   2288 C C   . VAL A 1 296 ? 3.97592  -22.11852 14.53047  1.000 14.00407  ? 296 VAL A C   1 
ATOM   2289 O O   . VAL A 1 296 ? 2.77049  -21.94016 14.74487  1.000 17.17249  ? 296 VAL A O   1 
ATOM   2290 C CB  . VAL A 1 296 ? 4.90426  -24.37682 13.85691  1.000 13.85489  ? 296 VAL A CB  1 
ATOM   2291 C CG1 . VAL A 1 296 ? 3.81832  -25.05973 14.80442  1.000 10.95671  ? 296 VAL A CG1 1 
ATOM   2292 C CG2 . VAL A 1 296 ? 5.21764  -25.28443 12.70022  1.000 11.93562  ? 296 VAL A CG2 1 
ATOM   2293 N N   . VAL A 1 297 ? 4.91246  -21.57164 15.29880  1.000 16.02776  ? 297 VAL A N   1 
ATOM   2294 C CA  . VAL A 1 297 ? 4.54912  -20.66655 16.39030  1.000 18.23550  ? 297 VAL A CA  1 
ATOM   2295 C C   . VAL A 1 297 ? 3.80623  -19.44165 15.86264  1.000 20.78406  ? 297 VAL A C   1 
ATOM   2296 O O   . VAL A 1 297 ? 2.81864  -18.99038 16.45135  1.000 21.65996  ? 297 VAL A O   1 
ATOM   2297 C CB  . VAL A 1 297 ? 5.81448  -20.28392 17.18255  1.000 16.13190  ? 297 VAL A CB  1 
ATOM   2298 C CG1 . VAL A 1 297 ? 5.51507  -19.13508 18.11628  1.000 19.85102  ? 297 VAL A CG1 1 
ATOM   2299 C CG2 . VAL A 1 297 ? 6.35803  -21.50215 17.94376  1.000 21.68530  ? 297 VAL A CG2 1 
ATOM   2300 N N   . ARG A 1 298 ? 4.24255  -18.90807 14.71958  1.000 19.83412  ? 298 ARG A N   1 
ATOM   2301 C CA  . ARG A 1 298 ? 3.61786  -17.72988 14.13908  1.000 19.35030  ? 298 ARG A CA  1 
ATOM   2302 C C   . ARG A 1 298 ? 2.15401  -17.97592 13.80983  1.000 25.76010  ? 298 ARG A C   1 
ATOM   2303 O O   . ARG A 1 298 ? 1.30686  -17.10738 14.01705  1.000 25.02382  ? 298 ARG A O   1 
ATOM   2304 C CB  . ARG A 1 298 ? 4.39626  -17.32500 12.87874  1.000 23.88365  ? 298 ARG A CB  1 
ATOM   2305 C CG  . ARG A 1 298 ? 3.88831  -16.12950 12.11671  1.000 32.07462  ? 298 ARG A CG  1 
ATOM   2306 C CD  . ARG A 1 298 ? 4.41023  -16.11847 10.64919  1.000 23.91642  ? 298 ARG A CD  1 
ATOM   2307 N NE  . ARG A 1 298 ? 3.44526  -15.50875 9.73135   1.000 39.26496  ? 298 ARG A NE  1 
ATOM   2308 C CZ  . ARG A 1 298 ? 3.40094  -15.67612 8.41004   1.000 30.14009  ? 298 ARG A CZ  1 
ATOM   2309 N NH1 . ARG A 1 298 ? 4.25646  -16.46898 7.76963   1.000 29.65466  ? 298 ARG A NH1 1 
ATOM   2310 N NH2 . ARG A 1 298 ? 2.46647  -15.03287 7.70723   1.000 19.89551  ? 298 ARG A NH2 1 
ATOM   2311 N N   . GLN A 1 299 ? 1.83279  -19.15047 13.30848  1.000 13.45898  ? 299 GLN A N   1 
ATOM   2312 C CA  . GLN A 1 299 ? 0.49857  -19.38968 12.79955  1.000 19.12312  ? 299 GLN A CA  1 
ATOM   2313 C C   . GLN A 1 299 ? -0.40741 -20.03579 13.83710  1.000 26.10474  ? 299 GLN A C   1 
ATOM   2314 O O   . GLN A 1 299 ? -1.60136 -19.73266 13.88951  1.000 21.48203  ? 299 GLN A O   1 
ATOM   2315 C CB  . GLN A 1 299 ? 0.59791  -20.25874 11.54578  1.000 20.40723  ? 299 GLN A CB  1 
ATOM   2316 C CG  . GLN A 1 299 ? -0.73133 -20.79377 11.13081  1.000 12.41797  ? 299 GLN A CG  1 
ATOM   2317 C CD  . GLN A 1 299 ? -0.76525 -21.46576 9.77349   1.000 15.35033  ? 299 GLN A CD  1 
ATOM   2318 O OE1 . GLN A 1 299 ? -1.84051 -21.88125 9.32740   1.000 17.01525  ? 299 GLN A OE1 1 
ATOM   2319 N NE2 . GLN A 1 299 ? 0.40181  -21.65147 9.14562   1.000 13.58190  ? 299 GLN A NE2 1 
ATOM   2320 N N   . CYS A 1 300 ? 0.12348  -20.88718 14.70106  1.000 20.83705  ? 300 CYS A N   1 
ATOM   2321 C CA  . CYS A 1 300 ? -0.72002 -21.46146 15.73769  1.000 21.25701  ? 300 CYS A CA  1 
ATOM   2322 C C   . CYS A 1 300 ? -0.92500 -20.52381 16.94203  1.000 26.32285  ? 300 CYS A C   1 
ATOM   2323 O O   . CYS A 1 300 ? -1.76508 -20.83478 17.80512  1.000 36.25545  ? 300 CYS A O   1 
ATOM   2324 C CB  . CYS A 1 300 ? -0.11423 -22.79090 16.20538  1.000 18.64736  ? 300 CYS A CB  1 
ATOM   2325 S SG  . CYS A 1 300 ? -0.02268 -24.05798 14.92437  1.000 29.08054  ? 300 CYS A SG  1 
ATOM   2326 N N   . SER A 1 301 ? -0.22865 -19.37230 17.00076  1.000 33.79483  ? 301 SER A N   1 
ATOM   2327 C CA  . SER A 1 301 ? -0.40544 -18.39230 18.07715  1.000 43.47498  ? 301 SER A CA  1 
ATOM   2328 C C   . SER A 1 301 ? -0.92565 -17.02833 17.62218  1.000 48.40542  ? 301 SER A C   1 
ATOM   2329 O O   . SER A 1 301 ? -1.44199 -16.27803 18.46535  1.000 47.45937  ? 301 SER A O   1 
ATOM   2330 C CB  . SER A 1 301 ? 0.91072  -18.14963 18.84015  1.000 57.07855  ? 301 SER A CB  1 
ATOM   2331 O OG  . SER A 1 301 ? 1.84440  -17.40630 18.05706  1.000 55.50176  ? 301 SER A OG  1 
ATOM   2332 N N   . GLY A 1 302 ? -0.78376 -16.66953 16.33805  1.000 50.93417  ? 302 GLY A N   1 
ATOM   2333 C CA  . GLY A 1 302 ? -1.51402 -15.54117 15.76492  1.000 42.74013  ? 302 GLY A CA  1 
ATOM   2334 C C   . GLY A 1 302 ? -0.79542 -14.20434 15.76599  1.000 53.23711  ? 302 GLY A C   1 
ATOM   2335 O O   . GLY A 1 302 ? -1.40752 -13.16322 16.04060  1.000 47.56339  ? 302 GLY A O   1 
ATOM   2336 N N   . VAL A 1 303 ? 0.50380  -14.22421 15.45318  1.000 46.95536  ? 303 VAL A N   1 
ATOM   2337 C CA  . VAL A 1 303 ? 1.31053  -13.00574 15.44084  1.000 68.77639  ? 303 VAL A CA  1 
ATOM   2338 C C   . VAL A 1 303 ? 0.99826  -12.18669 14.18809  1.000 67.65826  ? 303 VAL A C   1 
ATOM   2339 O O   . VAL A 1 303 ? 0.81313  -12.74536 13.09395  1.000 64.95546  ? 303 VAL A O   1 
ATOM   2340 C CB  . VAL A 1 303 ? 2.80687  -13.37210 15.52071  1.000 54.60545  ? 303 VAL A CB  1 
ATOM   2341 C CG1 . VAL A 1 303 ? 3.70428  -12.17676 15.14916  1.000 51.14461  ? 303 VAL A CG1 1 
ATOM   2342 C CG2 . VAL A 1 303 ? 3.15227  -13.91460 16.89936  1.000 44.45252  ? 303 VAL A CG2 1 
ATOM   2343 N N   . THR A 1 304 ? 0.95581  -10.84961 14.33796  1.000 53.90554  ? 304 THR A N   1 
ATOM   2344 C CA  . THR A 1 304 ? 0.62031  -9.89836  13.26596  1.000 53.59490  ? 304 THR A CA  1 
ATOM   2345 C C   . THR A 1 304 ? 1.80343  -8.97725  12.93956  1.000 60.87222  ? 304 THR A C   1 
ATOM   2346 O O   . THR A 1 304 ? 2.88850  -9.06837  13.53978  1.000 57.71950  ? 304 THR A O   1 
ATOM   2347 C CB  . THR A 1 304 ? -0.60940 -9.04776  13.63038  1.000 52.52952  ? 304 THR A CB  1 
ATOM   2348 O OG1 . THR A 1 304 ? -0.34271 -8.26065  14.80248  1.000 54.41811  ? 304 THR A OG1 1 
ATOM   2349 C CG2 . THR A 1 304 ? -1.80722 -9.93509  13.89135  1.000 39.25259  ? 304 THR A CG2 1 
ATOM   2350 N N   . PHE A 1 305 ? 1.56336  -8.06347  11.98346  1.000 56.84811  ? 305 PHE A N   1 
ATOM   2351 C CA  . PHE A 1 305 ? 2.61780  -7.20520  11.38645  1.000 67.98655  ? 305 PHE A CA  1 
ATOM   2352 C C   . PHE A 1 305 ? 2.13647  -5.77750  11.07002  1.000 61.22306  ? 305 PHE A C   1 
ATOM   2353 O O   . PHE A 1 305 ? 1.87417  -4.97414  11.97040  1.000 65.36751  ? 305 PHE A O   1 
ATOM   2354 C CB  . PHE A 1 305 ? 3.16260  -7.87327  10.10497  1.000 60.66778  ? 305 PHE A CB  1 
ATOM   2355 C CG  . PHE A 1 305 ? 3.57834  -9.28867  10.32797  1.000 47.30014  ? 305 PHE A CG  1 
ATOM   2356 C CD1 . PHE A 1 305 ? 4.81963  -9.57658  10.87122  1.000 32.82847  ? 305 PHE A CD1 1 
ATOM   2357 C CD2 . PHE A 1 305 ? 2.67314  -10.33251 10.10373  1.000 29.69161  ? 305 PHE A CD2 1 
ATOM   2358 C CE1 . PHE A 1 305 ? 5.17675  -10.88602 11.13911  1.000 53.33951  ? 305 PHE A CE1 1 
ATOM   2359 C CE2 . PHE A 1 305 ? 3.00186  -11.63057 10.38731  1.000 29.84743  ? 305 PHE A CE2 1 
ATOM   2360 C CZ  . PHE A 1 305 ? 4.26000  -11.92189 10.89790  1.000 59.79523  ? 305 PHE A CZ  1 
ATOM   2361 N N   . SER B 2 2   ? 18.16804 -29.38918 -20.92547 1.000 58.78127  ? 1   SER B N   1 
ATOM   2362 C CA  . SER B 2 2   ? 19.58601 -29.58753 -20.62071 1.000 52.96979  ? 1   SER B CA  1 
ATOM   2363 C C   . SER B 2 2   ? 20.26963 -28.32560 -20.06292 1.000 46.72459  ? 1   SER B C   1 
ATOM   2364 O O   . SER B 2 2   ? 21.25157 -28.42395 -19.32807 1.000 45.03479  ? 1   SER B O   1 
ATOM   2365 C CB  . SER B 2 2   ? 20.32391 -30.07346 -21.87207 1.000 50.96688  ? 1   SER B CB  1 
ATOM   2366 O OG  . SER B 2 2   ? 20.30294 -29.09360 -22.90034 1.000 66.73174  ? 1   SER B OG  1 
ATOM   2367 N N   . GLY B 2 3   ? 19.74969 -27.14498 -20.40674 1.000 50.98869  ? 2   GLY B N   1 
ATOM   2368 C CA  . GLY B 2 3   ? 20.37002 -25.90642 -19.96772 1.000 47.45179  ? 2   GLY B CA  1 
ATOM   2369 C C   . GLY B 2 3   ? 19.58688 -25.07456 -18.96337 1.000 32.34071  ? 2   GLY B C   1 
ATOM   2370 O O   . GLY B 2 3   ? 18.37041 -25.20230 -18.83336 1.000 39.75302  ? 2   GLY B O   1 
ATOM   2371 N N   . VAL B 2 4   ? 20.28945 -24.20127 -18.24077 1.000 37.04499  ? 3   VAL B N   1 
ATOM   2372 C CA  . VAL B 2 4   ? 19.61430 -23.22476 -17.39414 1.000 30.26739  ? 3   VAL B CA  1 
ATOM   2373 C C   . VAL B 2 4   ? 18.83282 -22.25162 -18.28040 1.000 25.75945  ? 3   VAL B C   1 
ATOM   2374 O O   . VAL B 2 4   ? 19.26669 -21.90179 -19.38101 1.000 35.60696  ? 3   VAL B O   1 
ATOM   2375 C CB  . VAL B 2 4   ? 20.66149 -22.48036 -16.54501 1.000 22.74751  ? 3   VAL B CB  1 
ATOM   2376 C CG1 . VAL B 2 4   ? 20.18316 -21.08485 -16.12007 1.000 35.89439  ? 3   VAL B CG1 1 
ATOM   2377 C CG2 . VAL B 2 4   ? 21.15049 -23.32955 -15.39162 1.000 29.33949  ? 3   VAL B CG2 1 
ATOM   2378 N N   . THR B 2 5   ? 17.68376 -21.79273 -17.79556 1.000 21.25587  ? 4   THR B N   1 
ATOM   2379 C CA  . THR B 2 5   ? 16.90922 -20.74389 -18.44962 1.000 21.27072  ? 4   THR B CA  1 
ATOM   2380 C C   . THR B 2 5   ? 16.92644 -19.49539 -17.56576 1.000 21.14764  ? 4   THR B C   1 
ATOM   2381 O O   . THR B 2 5   ? 16.40401 -19.52166 -16.45355 1.000 20.00534  ? 4   THR B O   1 
ATOM   2382 C CB  . THR B 2 5   ? 15.45529 -21.18940 -18.68501 1.000 23.64297  ? 4   THR B CB  1 
ATOM   2383 O OG1 . THR B 2 5   ? 15.41034 -22.41032 -19.43491 1.000 34.39387  ? 4   THR B OG1 1 
ATOM   2384 C CG2 . THR B 2 5   ? 14.68947 -20.12362 -19.42585 1.000 32.58325  ? 4   THR B CG2 1 
ATOM   2385 N N   . PHE B 2 6   ? 17.47468 -18.39539 -18.07219 1.000 19.81705  ? 5   PHE B N   1 
ATOM   2386 C CA  . PHE B 2 6   ? 17.38606 -17.11337 -17.39041 1.000 17.62106  ? 5   PHE B CA  1 
ATOM   2387 C C   . PHE B 2 6   ? 15.99326 -16.53489 -17.58591 1.000 23.11219  ? 5   PHE B C   1 
ATOM   2388 O O   . PHE B 2 6   ? 15.50745 -16.43404 -18.71553 1.000 29.75892  ? 5   PHE B O   1 
ATOM   2389 C CB  . PHE B 2 6   ? 18.49450 -16.18634 -17.88706 1.000 22.76287  ? 5   PHE B CB  1 
ATOM   2390 C CG  . PHE B 2 6   ? 19.83537 -16.79678 -17.70666 1.000 23.53707  ? 5   PHE B CG  1 
ATOM   2391 C CD1 . PHE B 2 6   ? 20.30714 -17.74718 -18.61223 1.000 45.96244  ? 5   PHE B CD1 1 
ATOM   2392 C CD2 . PHE B 2 6   ? 20.53277 -16.59283 -16.54263 1.000 23.45733  ? 5   PHE B CD2 1 
ATOM   2393 C CE1 . PHE B 2 6   ? 21.51906 -18.38810 -18.39958 1.000 46.44354  ? 5   PHE B CE1 1 
ATOM   2394 C CE2 . PHE B 2 6   ? 21.73206 -17.21465 -16.32282 1.000 39.44674  ? 5   PHE B CE2 1 
ATOM   2395 C CZ  . PHE B 2 6   ? 22.22435 -18.11938 -17.24359 1.000 42.45213  ? 5   PHE B CZ  1 
ATOM   2396 N N   . GLN B 2 7   ? 15.30812 -16.21289 -16.49252 1.000 19.74617  ? 6   GLN B N   1 
ATOM   2397 C CA  . GLN B 2 7   ? 13.88229 -15.93491 -16.64645 1.000 16.81942  ? 6   GLN B CA  1 
ATOM   2398 C C   . GLN B 2 7   ? 13.55690 -14.43941 -16.70807 1.000 18.33346  ? 6   GLN B C   1 
ATOM   2399 O O   . GLN B 2 7   ? 12.54142 -13.96709 -16.18528 1.000 16.21351  ? 6   GLN B O   1 
ATOM   2400 C CB  . GLN B 2 7   ? 13.08373 -16.66069 -15.56970 1.000 13.59139  ? 6   GLN B CB  1 
ATOM   2401 C CG  . GLN B 2 7   ? 13.00501 -18.11962 -15.94412 1.000 16.12398  ? 6   GLN B CG  1 
ATOM   2402 C CD  . GLN B 2 7   ? 12.20632 -18.96317 -14.95041 1.000 22.39139  ? 6   GLN B CD  1 
ATOM   2403 O OE1 . GLN B 2 7   ? 12.38932 -18.85989 -13.73826 1.000 18.95397  ? 6   GLN B OE1 1 
ATOM   2404 N NE2 . GLN B 2 7   ? 11.27436 -19.75534 -15.46382 1.000 15.17078  ? 6   GLN B NE2 1 
ATOM   2405 N N   . SER B 2 8   ? 14.39296 -13.67870 -17.41641 1.000 21.47942  ? 7   SER B N   1 
ATOM   2406 C CA  . SER B 2 8   ? 13.92216 -12.44734 -18.03319 1.000 22.61351  ? 7   SER B CA  1 
ATOM   2407 C C   . SER B 2 8   ? 12.92826 -12.80854 -19.13089 1.000 23.03720  ? 7   SER B C   1 
ATOM   2408 O O   . SER B 2 8   ? 12.69435 -13.98212 -19.43463 1.000 21.05636  ? 7   SER B O   1 
ATOM   2409 C CB  . SER B 2 8   ? 15.08237 -11.66389 -18.65603 1.000 20.65616  ? 7   SER B CB  1 
ATOM   2410 O OG  . SER B 2 8   ? 15.82990 -12.48973 -19.52560 1.000 19.79712  ? 7   SER B OG  1 
ATOM   2411 N N   . ALA B 2 9   ? 12.37982 -11.78123 -19.76160 1.000 24.24606  ? 8   ALA B N   1 
ATOM   2412 C CA  . ALA B 2 9   ? 11.53228 -11.94084 -20.93521 1.000 27.32440  ? 8   ALA B CA  1 
ATOM   2413 C C   . ALA B 2 9   ? 12.00017 -11.00460 -22.04395 1.000 29.60680  ? 8   ALA B C   1 
ATOM   2414 O O   . ALA B 2 9   ? 12.67144 -9.99123  -21.80223 1.000 28.65813  ? 8   ALA B O   1 
ATOM   2415 C CB  . ALA B 2 9   ? 10.05614 -11.65138 -20.62986 1.000 18.96626  ? 8   ALA B CB  1 
ATOM   2416 N N   . VAL B 2 10  ? 11.59866 -11.35180 -23.26806 1.000 36.20754  ? 9   VAL B N   1 
ATOM   2417 C CA  . VAL B 2 10  ? 11.79575 -10.47420 -24.41649 1.000 37.34272  ? 9   VAL B CA  1 
ATOM   2418 C C   . VAL B 2 10  ? 10.75036 -9.36498  -24.37752 1.000 30.73753  ? 9   VAL B C   1 
ATOM   2419 O O   . VAL B 2 10  ? 9.56329  -9.61122  -24.12210 1.000 35.83552  ? 9   VAL B O   1 
ATOM   2420 C CB  . VAL B 2 10  ? 11.70748 -11.26279 -25.73130 1.000 27.14115  ? 9   VAL B CB  1 
ATOM   2421 C CG1 . VAL B 2 10  ? 11.70091 -10.28870 -26.90373 1.000 34.63764  ? 9   VAL B CG1 1 
ATOM   2422 C CG2 . VAL B 2 10  ? 12.82525 -12.26933 -25.85190 1.000 30.23635  ? 9   VAL B CG2 1 
ATOM   2423 N N   . LYS B 2 11  ? 11.18595 -8.13271  -24.62111 1.000 36.45386  ? 10  LYS B N   1 
ATOM   2424 C CA  . LYS B 2 11  ? 10.27501 -6.98599  -24.61316 1.000 43.63699  ? 10  LYS B CA  1 
ATOM   2425 C C   . LYS B 2 11  ? 9.32850  -7.07232  -25.79688 1.000 51.32988  ? 10  LYS B C   1 
ATOM   2426 O O   . LYS B 2 11  ? 9.77252  -7.36875  -26.90850 1.000 45.93550  ? 10  LYS B O   1 
ATOM   2427 C CB  . LYS B 2 11  ? 11.06124 -5.67810  -24.66210 1.000 48.34547  ? 10  LYS B CB  1 
ATOM   2428 C CG  . LYS B 2 11  ? 10.22508 -4.42709  -24.40709 1.000 68.43874  ? 10  LYS B CG  1 
ATOM   2429 C CD  . LYS B 2 11  ? 9.56843  -4.39208  -23.01702 1.000 45.89646  ? 10  LYS B CD  1 
ATOM   2430 C CE  . LYS B 2 11  ? 9.32958  -2.93308  -22.63784 1.000 46.00386  ? 10  LYS B CE  1 
ATOM   2431 N NZ  . LYS B 2 11  ? 8.44831  -2.72368  -21.46299 1.000 57.45198  ? 10  LYS B NZ  1 
HETATM 2432 O O   . HOH C 3 .   ? 7.29166  -36.89011 25.87988  1.000 31.27930  ? 401 HOH A O   1 
HETATM 2433 O O   . HOH C 3 .   ? 17.19774 -28.48464 24.57723  1.000 38.59993  ? 402 HOH A O   1 
HETATM 2434 O O   . HOH C 3 .   ? 12.84341 -40.58082 2.72405   1.000 40.99573  ? 403 HOH A O   1 
HETATM 2435 O O   . HOH C 3 .   ? -0.82423 -22.30002 19.52471  1.000 30.71138  ? 404 HOH A O   1 
HETATM 2436 O O   . HOH C 3 .   ? -3.34273 -22.46424 18.73286  1.000 35.40118  ? 405 HOH A O   1 
HETATM 2437 O O   . HOH C 3 .   ? 10.75217 -36.19481 2.18873   1.000 29.15579  ? 406 HOH A O   1 
HETATM 2438 O O   . HOH C 3 .   ? 3.16221  -21.76916 19.97851  1.000 37.40397  ? 407 HOH A O   1 
HETATM 2439 O O   . HOH C 3 .   ? 19.23189 -0.41504  -23.65365 1.000 40.13427  ? 408 HOH A O   1 
HETATM 2440 O O   . HOH C 3 .   ? -2.03677 -7.99771  16.64101  1.000 34.51840  ? 409 HOH A O   1 
HETATM 2441 O O   . HOH C 3 .   ? 6.54588  -23.87945 0.92371   1.000 22.06147  ? 410 HOH A O   1 
HETATM 2442 O O   . HOH C 3 .   ? 22.41971 -39.71284 21.34014  1.000 29.35261  ? 411 HOH A O   1 
HETATM 2443 O O   . HOH C 3 .   ? -2.21832 -32.94301 23.12653  1.000 33.09195  ? 412 HOH A O   1 
HETATM 2444 O O   . HOH C 3 .   ? 4.75700  -17.10936 -11.36931 1.000 19.98430  ? 413 HOH A O   1 
HETATM 2445 O O   . HOH C 3 .   ? 13.33942 -25.90177 -16.67654 1.000 32.50989  ? 414 HOH A O   1 
HETATM 2446 O O   . HOH C 3 .   ? -7.11605 -38.78502 6.38238   1.000 36.24816  ? 415 HOH A O   1 
HETATM 2447 O O   . HOH C 3 .   ? 5.65714  -0.64483  -0.15147  1.000 25.38319  ? 416 HOH A O   1 
HETATM 2448 O O   . HOH C 3 .   ? 32.05891 -2.92379  -16.00564 1.000 34.19893  ? 417 HOH A O   1 
HETATM 2449 O O   . HOH C 3 .   ? 24.83082 -21.85582 4.78724   1.000 17.24141  ? 418 HOH A O   1 
HETATM 2450 O O   . HOH C 3 .   ? 5.35684  -9.61628  14.10378  1.000 45.26030  ? 419 HOH A O   1 
HETATM 2451 O O   . HOH C 3 .   ? 25.06772 -7.35347  -25.56173 1.000 53.23670  ? 420 HOH A O   1 
HETATM 2452 O O   . HOH C 3 .   ? 28.93017 1.65466   -17.69627 1.000 35.26332  ? 421 HOH A O   1 
HETATM 2453 O O   . HOH C 3 .   ? -4.73119 -25.91304 20.05947  1.000 41.03919  ? 422 HOH A O   1 
HETATM 2454 O O   . HOH C 3 .   ? 8.67579  -17.62115 6.39203   1.000 16.46344  ? 423 HOH A O   1 
HETATM 2455 O O   . HOH C 3 .   ? 7.17153  -30.28148 1.89076   1.000 30.58547  ? 424 HOH A O   1 
HETATM 2456 O O   . HOH C 3 .   ? 20.95106 -24.68083 13.69503  1.000 33.31953  ? 425 HOH A O   1 
HETATM 2457 O O   . HOH C 3 .   ? 17.78522 -23.37394 8.63331   1.000 28.67944  ? 426 HOH A O   1 
HETATM 2458 O O   . HOH C 3 .   ? 14.30028 9.60799   -18.21399 1.000 42.95531  ? 427 HOH A O   1 
HETATM 2459 O O   . HOH C 3 .   ? 24.34917 -1.00935  -1.83666  1.000 34.59760  ? 428 HOH A O   1 
HETATM 2460 O O   . HOH C 3 .   ? 9.72466  -31.96055 0.99754   1.000 37.22032  ? 429 HOH A O   1 
HETATM 2461 O O   . HOH C 3 .   ? 24.08213 -41.13682 14.60162  1.000 32.62025  ? 430 HOH A O   1 
HETATM 2462 O O   . HOH C 3 .   ? 21.81518 -30.87201 9.67495   1.000 33.19645  ? 431 HOH A O   1 
HETATM 2463 O O   . HOH C 3 .   ? 12.38068 -8.66023  9.24775   1.000 24.94169  ? 432 HOH A O   1 
HETATM 2464 O O   . HOH C 3 .   ? -3.38163 -32.59460 20.72975  1.000 26.20105  ? 433 HOH A O   1 
HETATM 2465 O O   . HOH C 3 .   ? 18.45422 10.05254  -6.04413  1.000 37.86634  ? 434 HOH A O   1 
HETATM 2466 O O   . HOH C 3 .   ? 31.48577 -8.19356  -4.26736  1.000 25.10202  ? 435 HOH A O   1 
HETATM 2467 O O   . HOH C 3 .   ? 27.28480 -9.49258  0.00000   0.50  26.18836  ? 436 HOH A O   1 
HETATM 2468 O O   . HOH C 3 .   ? 5.43128  -15.20463 -18.49012 1.000 37.16673  ? 437 HOH A O   1 
HETATM 2469 O O   . HOH C 3 .   ? 21.16443 -37.25228 -0.78018  1.000 42.38094  ? 438 HOH A O   1 
HETATM 2470 O O   . HOH C 3 .   ? 8.82061  -9.10754  -16.47139 1.000 21.63367  ? 439 HOH A O   1 
HETATM 2471 O O   . HOH C 3 .   ? 9.49861  -38.22371 4.04073   1.000 21.52934  ? 440 HOH A O   1 
HETATM 2472 O O   . HOH C 3 .   ? 1.21733  -34.04566 25.74113  1.000 34.62696  ? 441 HOH A O   1 
HETATM 2473 O O   . HOH C 3 .   ? 23.99120 -15.90811 6.17017   1.000 17.41770  ? 442 HOH A O   1 
HETATM 2474 O O   . HOH C 3 .   ? -7.97050 -27.49725 16.91341  1.000 35.14369  ? 443 HOH A O   1 
HETATM 2475 O O   . HOH C 3 .   ? -4.91279 -22.63598 13.60208  1.000 22.07294  ? 444 HOH A O   1 
HETATM 2476 O O   . HOH C 3 .   ? 15.71518 -11.01561 -23.96757 1.000 39.29413  ? 445 HOH A O   1 
HETATM 2477 O O   . HOH C 3 .   ? 15.30752 -24.72256 23.99080  1.000 33.73185  ? 446 HOH A O   1 
HETATM 2478 O O   . HOH C 3 .   ? 28.79487 -13.66378 -5.48221  1.000 15.05880  ? 447 HOH A O   1 
HETATM 2479 O O   . HOH C 3 .   ? 11.22470 -1.10998  -18.33495 1.000 29.09414  ? 448 HOH A O   1 
HETATM 2480 O O   . HOH C 3 .   ? 21.54276 -37.34518 7.61710   1.000 25.15144  ? 449 HOH A O   1 
HETATM 2481 O O   . HOH C 3 .   ? 18.35564 1.30474   -1.51984  1.000 22.42703  ? 450 HOH A O   1 
HETATM 2482 O O   . HOH C 3 .   ? 8.79326  -9.54717  -5.88675  1.000 16.02340  ? 451 HOH A O   1 
HETATM 2483 O O   . HOH C 3 .   ? 9.94728  -24.35189 18.98505  1.000 24.89215  ? 452 HOH A O   1 
HETATM 2484 O O   . HOH C 3 .   ? 21.78776 -38.29110 9.98063   1.000 38.41536  ? 453 HOH A O   1 
HETATM 2485 O O   . HOH C 3 .   ? 11.22344 -24.61327 -1.96613  1.000 10.14304  ? 454 HOH A O   1 
HETATM 2486 O O   . HOH C 3 .   ? -7.90275 -22.78231 17.54881  1.000 28.21108  ? 455 HOH A O   1 
HETATM 2487 O O   . HOH C 3 .   ? 27.00847 -20.18433 -2.60481  1.000 13.63519  ? 456 HOH A O   1 
HETATM 2488 O O   . HOH C 3 .   ? -5.61182 -38.39981 15.47204  1.000 31.07307  ? 457 HOH A O   1 
HETATM 2489 O O   . HOH C 3 .   ? 22.36912 -27.12401 13.45728  1.000 27.14680  ? 458 HOH A O   1 
HETATM 2490 O O   . HOH C 3 .   ? 13.21480 11.62593  -4.57857  1.000 36.28396  ? 459 HOH A O   1 
HETATM 2491 O O   . HOH C 3 .   ? 10.67409 -18.98713 9.49839   1.000 20.45575  ? 460 HOH A O   1 
HETATM 2492 O O   . HOH C 3 .   ? 22.53556 -27.63252 3.04593   1.000 20.69674  ? 461 HOH A O   1 
HETATM 2493 O O   . HOH C 3 .   ? 21.12631 -27.91439 4.99995   1.000 29.56320  ? 462 HOH A O   1 
HETATM 2494 O O   . HOH C 3 .   ? 20.57120 -29.12405 8.39207   1.000 44.53037  ? 463 HOH A O   1 
HETATM 2495 O O   . HOH C 3 .   ? 24.51807 -11.23994 1.56886   1.000 12.81981  ? 464 HOH A O   1 
HETATM 2496 O O   . HOH C 3 .   ? 12.61385 -18.26981 7.71625   1.000 21.48520  ? 465 HOH A O   1 
HETATM 2497 O O   . HOH C 3 .   ? 6.18325  4.47887   -5.23009  1.000 35.07009  ? 466 HOH A O   1 
HETATM 2498 O O   . HOH C 3 .   ? 4.25606  -20.05123 -12.82744 1.000 19.23411  ? 467 HOH A O   1 
HETATM 2499 O O   . HOH C 3 .   ? 19.91508 -20.65244 -5.80514  1.000 12.49425  ? 468 HOH A O   1 
HETATM 2500 O O   . HOH C 3 .   ? 7.35460  -28.51200 7.84537   1.000 12.68023  ? 469 HOH A O   1 
HETATM 2501 O O   . HOH C 3 .   ? 23.09123 -27.77947 -5.29384  1.000 20.74267  ? 470 HOH A O   1 
HETATM 2502 O O   . HOH C 3 .   ? 20.61609 -25.01996 7.91852   1.000 31.22046  ? 471 HOH A O   1 
HETATM 2503 O O   . HOH C 3 .   ? -5.80325 -37.37077 10.11636  1.000 38.14578  ? 472 HOH A O   1 
HETATM 2504 O O   . HOH C 3 .   ? -2.95526 -12.25878 18.17265  1.000 44.20371  ? 473 HOH A O   1 
HETATM 2505 O O   . HOH C 3 .   ? 9.63058  -43.36668 4.38304   1.000 34.02385  ? 474 HOH A O   1 
HETATM 2506 O O   . HOH C 3 .   ? 27.69730 -16.07407 -11.36816 1.000 17.14947  ? 475 HOH A O   1 
HETATM 2507 O O   . HOH C 3 .   ? 6.19213  -21.66440 5.78084   1.000 14.58313  ? 476 HOH A O   1 
HETATM 2508 O O   . HOH C 3 .   ? 27.55536 -17.37399 -3.20711  1.000 12.53042  ? 477 HOH A O   1 
HETATM 2509 O O   . HOH C 3 .   ? 20.95588 -16.06522 8.20431   1.000 23.82634  ? 478 HOH A O   1 
HETATM 2510 O O   . HOH C 3 .   ? -1.70060 -41.88924 3.36090   1.000 38.47009  ? 479 HOH A O   1 
HETATM 2511 O O   . HOH C 3 .   ? 22.79440 -4.89515  -2.69584  1.000 21.89104  ? 480 HOH A O   1 
HETATM 2512 O O   . HOH C 3 .   ? 27.68318 -19.80461 -6.63972  1.000 13.90286  ? 481 HOH A O   1 
HETATM 2513 O O   . HOH C 3 .   ? 19.78167 -10.57474 0.98591   1.000 14.85989  ? 482 HOH A O   1 
HETATM 2514 O O   . HOH C 3 .   ? 15.85165 -10.82503 9.47217   1.000 35.26379  ? 483 HOH A O   1 
HETATM 2515 O O   . HOH C 3 .   ? 18.55640 -29.27557 -12.26262 1.000 27.85215  ? 484 HOH A O   1 
HETATM 2516 O O   . HOH C 3 .   ? 18.95292 -34.19367 22.28814  1.000 36.23174  ? 485 HOH A O   1 
HETATM 2517 O O   . HOH C 3 .   ? 23.91018 -17.41490 8.64111   1.000 23.30029  ? 486 HOH A O   1 
HETATM 2518 O O   . HOH C 3 .   ? 30.97600 -7.28713  -7.68646  1.000 25.89734  ? 487 HOH A O   1 
HETATM 2519 O O   . HOH C 3 .   ? 7.70631  -0.62064  6.95181   1.000 25.87412  ? 488 HOH A O   1 
HETATM 2520 O O   . HOH C 3 .   ? 27.13903 -15.34304 -6.82864  1.000 14.45817  ? 489 HOH A O   1 
HETATM 2521 O O   . HOH C 3 .   ? 14.67798 -22.60149 12.01680  1.000 34.73812  ? 490 HOH A O   1 
HETATM 2522 O O   . HOH C 3 .   ? 30.24173 -8.61256  -10.06548 1.000 23.50805  ? 491 HOH A O   1 
HETATM 2523 O O   . HOH C 3 .   ? 23.49258 -19.58903 3.58789   1.000 14.79014  ? 492 HOH A O   1 
HETATM 2524 O O   . HOH C 3 .   ? 31.67517 -11.87375 -6.17958  1.000 22.34050  ? 493 HOH A O   1 
HETATM 2525 O O   . HOH C 3 .   ? 1.33150  -26.07220 27.51498  1.000 44.90435  ? 494 HOH A O   1 
HETATM 2526 O O   . HOH C 3 .   ? 14.53530 -30.84719 -4.34882  1.000 29.51849  ? 495 HOH A O   1 
HETATM 2527 O O   . HOH C 3 .   ? 12.61392 -32.29300 24.66666  1.000 34.23888  ? 496 HOH A O   1 
HETATM 2528 O O   . HOH C 3 .   ? 3.57611  -20.71287 6.56611   1.000 15.04700  ? 497 HOH A O   1 
HETATM 2529 O O   . HOH C 3 .   ? 10.13629 -15.65106 9.38215   1.000 34.53024  ? 498 HOH A O   1 
HETATM 2530 O O   . HOH C 3 .   ? 25.35222 -21.52965 -0.81015  1.000 13.13162  ? 499 HOH A O   1 
HETATM 2531 O O   . HOH C 3 .   ? 6.90013  -17.32237 15.32527  1.000 30.85938  ? 500 HOH A O   1 
HETATM 2532 O O   . HOH C 3 .   ? 8.28261  -33.85189 1.71406   1.000 34.42027  ? 501 HOH A O   1 
HETATM 2533 O O   . HOH C 3 .   ? 20.54658 -4.80788  5.27339   1.000 22.89807  ? 502 HOH A O   1 
HETATM 2534 O O   . HOH C 3 .   ? 22.07721 -12.46033 -13.34259 1.000 13.10085  ? 503 HOH A O   1 
HETATM 2535 O O   . HOH C 3 .   ? 6.20016  -40.38942 20.30563  1.000 32.94484  ? 504 HOH A O   1 
HETATM 2536 O O   . HOH C 3 .   ? -5.30317 -34.80433 8.31961   1.000 30.62847  ? 505 HOH A O   1 
HETATM 2537 O O   . HOH C 3 .   ? 12.06437 -33.51971 0.66096   1.000 31.13187  ? 506 HOH A O   1 
HETATM 2538 O O   . HOH C 3 .   ? 14.21232 -28.98752 23.38754  1.000 40.73140  ? 507 HOH A O   1 
HETATM 2539 O O   . HOH C 3 .   ? -0.01604 -29.77356 5.94606   1.000 21.27400  ? 508 HOH A O   1 
HETATM 2540 O O   . HOH C 3 .   ? 14.11555 -13.13274 5.13331   1.000 16.78982  ? 509 HOH A O   1 
HETATM 2541 O O   . HOH C 3 .   ? 18.31876 -0.91579  5.83917   1.000 36.50815  ? 510 HOH A O   1 
HETATM 2542 O O   . HOH C 3 .   ? 14.66830 -24.72937 9.61749   1.000 20.46768  ? 511 HOH A O   1 
HETATM 2543 O O   . HOH C 3 .   ? 20.19727 -38.59536 22.85067  1.000 39.04019  ? 512 HOH A O   1 
HETATM 2544 O O   . HOH C 3 .   ? -5.62558 -31.51191 1.67320   1.000 35.82274  ? 513 HOH A O   1 
HETATM 2545 O O   . HOH C 3 .   ? 18.63531 -46.31203 14.50117  1.000 32.17757  ? 514 HOH A O   1 
HETATM 2546 O O   . HOH C 3 .   ? 2.96818  -20.22943 9.26717   1.000 18.83881  ? 515 HOH A O   1 
HETATM 2547 O O   . HOH C 3 .   ? 2.13991  -43.51706 3.50498   1.000 44.99457  ? 516 HOH A O   1 
HETATM 2548 O O   . HOH C 3 .   ? 27.38624 -24.26185 -11.33775 1.000 26.96575  ? 517 HOH A O   1 
HETATM 2549 O O   . HOH C 3 .   ? 30.17268 -1.76499  -11.37394 1.000 24.19484  ? 518 HOH A O   1 
HETATM 2550 O O   . HOH C 3 .   ? 11.14429 -20.58556 -18.26314 1.000 26.25601  ? 519 HOH A O   1 
HETATM 2551 O O   . HOH C 3 .   ? 26.64140 7.51704   -14.17671 1.000 31.92158  ? 520 HOH A O   1 
HETATM 2552 O O   . HOH C 3 .   ? 15.97330 -29.38167 -6.14533  1.000 27.43527  ? 521 HOH A O   1 
HETATM 2553 O O   . HOH C 3 .   ? 24.12577 -28.17383 -0.54798  1.000 18.09950  ? 522 HOH A O   1 
HETATM 2554 O O   . HOH C 3 .   ? 10.03476 -45.47934 16.64892  1.000 37.67173  ? 523 HOH A O   1 
HETATM 2555 O O   . HOH C 3 .   ? 22.43865 -34.42484 4.23945   1.000 39.53522  ? 524 HOH A O   1 
HETATM 2556 O O   . HOH C 3 .   ? 23.61321 -37.36641 16.94450  1.000 43.68253  ? 525 HOH A O   1 
HETATM 2557 O O   . HOH C 3 .   ? 16.48842 -17.29569 8.83427   1.000 35.45654  ? 526 HOH A O   1 
HETATM 2558 O O   . HOH C 3 .   ? -3.25321 -44.57898 15.42052  1.000 45.65296  ? 527 HOH A O   1 
HETATM 2559 O O   . HOH C 3 .   ? 4.64966  -39.16388 22.57064  1.000 36.93623  ? 528 HOH A O   1 
HETATM 2560 O O   . HOH C 3 .   ? -2.16298 -17.16119 12.55345  1.000 34.88044  ? 529 HOH A O   1 
HETATM 2561 O O   . HOH C 3 .   ? 17.30754 6.15508   -17.55971 1.000 31.61906  ? 530 HOH A O   1 
HETATM 2562 O O   . HOH C 3 .   ? 6.85576  -38.14876 3.00458   1.000 24.89386  ? 531 HOH A O   1 
HETATM 2563 O O   . HOH C 3 .   ? 25.13062 -20.00249 1.57132   1.000 13.75508  ? 532 HOH A O   1 
HETATM 2564 O O   . HOH C 3 .   ? 9.99303  10.53712  -3.11442  1.000 38.24911  ? 533 HOH A O   1 
HETATM 2565 O O   . HOH C 3 .   ? 13.25559 2.45169   5.32314   1.000 33.13982  ? 534 HOH A O   1 
HETATM 2566 O O   . HOH C 3 .   ? 15.70656 -30.56454 -8.55728  1.000 38.10647  ? 535 HOH A O   1 
HETATM 2567 O O   . HOH C 3 .   ? 1.10132  -30.14869 3.72444   1.000 28.96509  ? 536 HOH A O   1 
HETATM 2568 O O   . HOH C 3 .   ? 15.11062 0.56078   6.37803   1.000 26.63215  ? 537 HOH A O   1 
HETATM 2569 O O   . HOH C 3 .   ? 18.59086 -18.05773 8.11980   1.000 20.89478  ? 538 HOH A O   1 
HETATM 2570 O O   . HOH C 3 .   ? 12.54714 -21.49194 13.08091  1.000 18.08263  ? 539 HOH A O   1 
HETATM 2571 O O   . HOH C 3 .   ? 6.43735  -25.53287 -7.15292  1.000 34.00818  ? 540 HOH A O   1 
HETATM 2572 O O   . HOH C 3 .   ? -6.05250 -39.74193 8.76428   1.000 38.47129  ? 541 HOH A O   1 
HETATM 2573 O O   . HOH C 3 .   ? 27.96967 -17.12983 -8.66376  1.000 14.64341  ? 542 HOH A O   1 
HETATM 2574 O O   . HOH C 3 .   ? 20.09672 -7.00375  -22.91663 1.000 36.39949  ? 543 HOH A O   1 
HETATM 2575 O O   . HOH C 3 .   ? 14.12162 -34.37285 24.05267  1.000 27.08784  ? 544 HOH A O   1 
HETATM 2576 O O   . HOH C 3 .   ? 13.38402 -32.78811 -1.77456  1.000 35.28600  ? 545 HOH A O   1 
HETATM 2577 O O   . HOH C 3 .   ? 6.79181  -42.33882 5.06776   1.000 39.35950  ? 546 HOH A O   1 
HETATM 2578 O O   . HOH C 3 .   ? 1.85189  -1.51466  4.10857   1.000 40.51031  ? 547 HOH A O   1 
HETATM 2579 O O   . HOH C 3 .   ? 23.11397 8.35708   -20.16809 1.000 37.31007  ? 548 HOH A O   1 
HETATM 2580 O O   . HOH C 3 .   ? 4.12939  -10.49298 -20.23365 1.000 44.94956  ? 549 HOH A O   1 
HETATM 2581 O O   . HOH C 3 .   ? 17.23185 -30.57432 10.20117  1.000 19.47775  ? 550 HOH A O   1 
HETATM 2582 O O   . HOH C 3 .   ? 21.28328 -31.83101 0.42527   1.000 30.66737  ? 551 HOH A O   1 
HETATM 2583 O O   . HOH C 3 .   ? -4.651   -28.509   7.213     1.000 41.77393  ? 552 HOH A O   1 
HETATM 2584 O O   . HOH C 3 .   ? 27.40280 5.05585   -13.10926 1.000 29.51695  ? 553 HOH A O   1 
HETATM 2585 O O   . HOH C 3 .   ? 23.94716 -34.35084 14.32226  1.000 37.31195  ? 554 HOH A O   1 
HETATM 2586 O O   . HOH C 3 .   ? 18.25811 -27.34544 5.98464   1.000 28.87017  ? 555 HOH A O   1 
HETATM 2587 O O   . HOH C 3 .   ? 11.13608 -28.00535 26.02554  1.000 37.54065  ? 556 HOH A O   1 
HETATM 2588 O O   . HOH C 3 .   ? 18.75278 -7.54470  -25.28981 1.000 40.91952  ? 557 HOH A O   1 
HETATM 2589 O O   . HOH C 3 .   ? 24.33500 -28.30774 17.54600  1.000 29.93082  ? 558 HOH A O   1 
HETATM 2590 O O   . HOH C 3 .   ? 23.25545 -43.48882 20.84199  1.000 41.82778  ? 559 HOH A O   1 
HETATM 2591 O O   . HOH C 3 .   ? -0.00000 -34.95003 0.00000   0.50  9.29516   ? 560 HOH A O   1 
HETATM 2592 O O   . HOH C 3 .   ? 8.20714  -31.50945 26.83871  1.000 39.43064  ? 561 HOH A O   1 
HETATM 2593 O O   . HOH C 3 .   ? 29.776   -26.928   -14.974   1.000 38.10707  ? 562 HOH A O   1 
HETATM 2594 O O   . HOH C 3 .   ? -3.92030 -23.76286 16.06895  1.000 22.74816  ? 563 HOH A O   1 
HETATM 2595 O O   . HOH C 3 .   ? 28.17209 -23.85739 -3.43124  1.000 18.64952  ? 564 HOH A O   1 
HETATM 2596 O O   . HOH C 3 .   ? -0.00000 -17.73225 0.00000   0.50  25.86184  ? 565 HOH A O   1 
HETATM 2597 O O   . HOH C 3 .   ? 24.43167 -33.17680 -9.36910  1.000 40.06662  ? 566 HOH A O   1 
HETATM 2598 O O   . HOH C 3 .   ? 5.70090  -1.23697  -14.84674 1.000 40.62776  ? 567 HOH A O   1 
HETATM 2599 O O   . HOH C 3 .   ? 5.95270  -27.88974 -0.22714  1.000 35.70135  ? 568 HOH A O   1 
HETATM 2600 O O   . HOH C 3 .   ? 2.92292  -1.80173  -11.84118 1.000 44.14267  ? 569 HOH A O   1 
HETATM 2601 O O   . HOH C 3 .   ? -3.65720 -26.91173 21.76679  1.000 36.82428  ? 570 HOH A O   1 
HETATM 2602 O O   . HOH C 3 .   ? 21.83994 -5.49968  -24.27287 1.000 32.22611  ? 571 HOH A O   1 
HETATM 2603 O O   . HOH C 3 .   ? -9.32560 -24.56249 19.06794  1.000 34.50749  ? 572 HOH A O   1 
HETATM 2604 O O   . HOH C 3 .   ? 26.22369 -29.69320 -7.61828  1.000 33.06757  ? 573 HOH A O   1 
HETATM 2605 O O   . HOH C 3 .   ? 10.21373 -13.42034 10.19239  1.000 36.03283  ? 574 HOH A O   1 
HETATM 2606 O O   . HOH C 3 .   ? 8.74578  -33.80951 27.69412  1.000 37.97143  ? 575 HOH A O   1 
HETATM 2607 O O   . HOH C 3 .   ? -0.86742 -30.89027 23.59337  1.000 39.75136  ? 576 HOH A O   1 
HETATM 2608 O O   . HOH C 3 .   ? -8.528   -28.070   11.947    1.000 39.82569  ? 577 HOH A O   1 
HETATM 2609 O O   . HOH C 3 .   ? 25.50498 4.73938   -9.04362  1.000 37.63875  ? 578 HOH A O   1 
HETATM 2610 O O   . HOH C 3 .   ? 18.44960 -24.47666 12.35106  1.000 40.81949  ? 579 HOH A O   1 
HETATM 2611 O O   . HOH C 3 .   ? 1.84297  -32.64151 -0.02246  1.000 36.53563  ? 580 HOH A O   1 
HETATM 2612 O O   . HOH C 3 .   ? 13.55427 -7.81390  11.62572  1.000 31.92149  ? 581 HOH A O   1 
HETATM 2613 O O   . HOH C 3 .   ? 3.13786  0.08277   0.00660   1.000 33.99230  ? 582 HOH A O   1 
HETATM 2614 O O   . HOH C 3 .   ? 23.45735 -30.21976 3.09776   1.000 33.51465  ? 583 HOH A O   1 
HETATM 2615 O O   . HOH C 3 .   ? 22.38161 -27.70999 10.89115  1.000 28.84800  ? 584 HOH A O   1 
HETATM 2616 O O   . HOH C 3 .   ? 17.17657 -26.05951 9.06249   1.000 29.48468  ? 585 HOH A O   1 
HETATM 2617 O O   . HOH C 3 .   ? 23.10823 -5.75464  5.06315   1.000 39.62695  ? 586 HOH A O   1 
HETATM 2618 O O   . HOH C 3 .   ? 25.30478 -17.98349 5.15790   1.000 14.62159  ? 587 HOH A O   1 
HETATM 2619 O O   . HOH C 3 .   ? 29.42008 0.12721   -13.68472 1.000 39.04327  ? 588 HOH A O   1 
HETATM 2620 O O   . HOH C 3 .   ? 9.47626  -22.08759 18.08002  1.000 34.70017  ? 589 HOH A O   1 
HETATM 2621 O O   . HOH C 3 .   ? 23.35126 -3.24886  -0.72070  1.000 32.19823  ? 590 HOH A O   1 
HETATM 2622 O O   . HOH C 3 .   ? 5.35179  -32.44455 0.90937   1.000 37.97448  ? 591 HOH A O   1 
HETATM 2623 O O   . HOH C 3 .   ? 30.68996 -0.07099  -15.80982 1.000 36.55701  ? 592 HOH A O   1 
HETATM 2624 O O   . HOH C 3 .   ? 18.18848 -28.61542 8.57264   1.000 22.92610  ? 593 HOH A O   1 
HETATM 2625 O O   . HOH C 3 .   ? 22.27272 -10.00775 2.21822   1.000 15.80332  ? 594 HOH A O   1 
HETATM 2626 O O   . HOH C 3 .   ? 14.21400 -15.63352 8.55453   1.000 36.12304  ? 595 HOH A O   1 
HETATM 2627 O O   . HOH C 3 .   ? 12.06486 -11.43129 9.53520   1.000 35.85136  ? 596 HOH A O   1 
HETATM 2628 O O   . HOH C 3 .   ? 23.21497 -41.97116 22.86055  1.000 39.07512  ? 597 HOH A O   1 
HETATM 2629 O O   . HOH C 3 .   ? 26.82719 -26.78993 -9.88080  1.000 32.87850  ? 598 HOH A O   1 
HETATM 2630 O O   . HOH C 3 .   ? 23.20906 -23.36398 12.84731  1.000 39.60349  ? 599 HOH A O   1 
HETATM 2631 O O   . HOH C 3 .   ? 30.17379 -16.12947 -12.26569 1.000 33.54954  ? 600 HOH A O   1 
HETATM 2632 O O   . HOH C 3 .   ? 16.11627 -24.62958 12.05755  1.000 37.96655  ? 601 HOH A O   1 
HETATM 2633 O O   . HOH C 3 .   ? 14.76335 -13.15110 7.92283   1.000 25.20041  ? 602 HOH A O   1 
HETATM 2634 O O   . HOH C 3 .   ? 11.30472 -32.63773 27.17399  1.000 40.95280  ? 603 HOH A O   1 
HETATM 2635 O O   . HOH C 3 .   ? 26.68576 -23.92809 -1.29208  1.000 16.99921  ? 604 HOH A O   1 
HETATM 2636 O O   . HOH C 3 .   ? 20.45520 -36.26887 23.36775  1.000 32.78000  ? 605 HOH A O   1 
HETATM 2637 O O   . HOH C 3 .   ? 24.22959 -38.20046 10.79453  1.000 36.67006  ? 606 HOH A O   1 
HETATM 2638 O O   . HOH C 3 .   ? 25.74609 -28.21699 -4.32658  1.000 33.55990  ? 607 HOH A O   1 
HETATM 2639 O O   . HOH C 3 .   ? 29.10546 -24.05288 -13.26639 1.000 34.26126  ? 608 HOH A O   1 
HETATM 2640 O O   . HOH C 3 .   ? 10.68875 -40.70651 3.43835   1.000 36.93556  ? 609 HOH A O   1 
HETATM 2641 O O   . HOH C 3 .   ? 5.71729  -40.75885 3.46808   1.000 44.73267  ? 610 HOH A O   1 
HETATM 2642 O O   . HOH C 3 .   ? -1.22958 -33.89693 27.45339  1.000 38.48245  ? 611 HOH A O   1 
HETATM 2643 O O   . HOH C 3 .   ? 24.50925 -31.87178 10.33520  1.000 32.18252  ? 612 HOH A O   1 
HETATM 2644 O O   . HOH C 3 .   ? 14.86898 -33.18796 -5.61237  1.000 38.13010  ? 613 HOH A O   1 
HETATM 2645 O O   . HOH C 3 .   ? 27.96261 -5.84248  -25.99561 1.000 34.86021  ? 614 HOH A O   1 
HETATM 2646 O O   . HOH C 3 .   ? 24.02682 -26.46977 6.43016   1.000 36.46409  ? 615 HOH A O   1 
HETATM 2647 O O   . HOH C 3 .   ? 5.65602  -20.43208 21.87348  1.000 37.74769  ? 616 HOH A O   1 
HETATM 2648 O O   . HOH C 3 .   ? 31.49071 -3.56283  -12.93609 1.000 39.30150  ? 617 HOH A O   1 
HETATM 2649 O O   . HOH C 3 .   ? 13.74639 -36.59295 26.11830  1.000 37.77182  ? 618 HOH A O   1 
HETATM 2650 O O   . HOH C 3 .   ? 25.65810 -26.33374 -1.91503  1.000 31.00572  ? 619 HOH A O   1 
HETATM 2651 O O   . HOH C 3 .   ? 26.18699 -28.46325 1.03817   1.000 36.56974  ? 620 HOH A O   1 
HETATM 2652 O O   . HOH C 3 .   ? 29.742   -26.182   -4.018    1.000 24.22104  ? 621 HOH A O   1 
HETATM 2653 O O   . HOH C 3 .   ? 27.69800 -27.40702 -3.18155  1.000 33.79008  ? 622 HOH A O   1 
HETATM 2654 O O   . HOH C 3 .   ? 25.60663 -33.13921 12.24370  1.000 38.98469  ? 623 HOH A O   1 
HETATM 2655 O O   . HOH C 3 .   ? 8.12732  -19.38419 21.05053  1.000 36.88636  ? 624 HOH A O   1 
HETATM 2656 O O   . HOH C 3 .   ? 26.02665 -37.06897 9.27674   1.000 33.24555  ? 625 HOH A O   1 
HETATM 2657 O O   . HOH D 3 .   ? 18.51813 -12.19512 -19.60536 1.000 30.45320  ? 101 HOH B O   1 
HETATM 2658 O O   . HOH D 3 .   ? 20.400   -29.906   -25.531   1.000 46.29437  ? 102 HOH B O   1 
HETATM 2659 O O   . HOH D 3 .   ? 15.75034 -24.63503 -17.81911 1.000 32.20735  ? 103 HOH B O   1 
HETATM 2660 O O   . HOH D 3 .   ? 14.69187 -12.87902 -22.06286 1.000 31.87632  ? 104 HOH B O   1 
HETATM 2661 O O   . HOH D 3 .   ? 10.73186 -14.33985 -23.45666 1.000 41.17075  ? 105 HOH B O   1 
HETATM 2662 O O   . HOH D 3 .   ? 7.69372  -8.49956  -21.73475 1.000 41.58725  ? 106 HOH B O   1 
HETATM 2663 O O   . HOH D 3 .   ? 13.55401 -15.50186 -22.25539 1.000 44.03426  ? 107 HOH B O   1 
HETATM 2664 O O   . HOH D 3 .   ? 6.45885  -6.06934  -25.24854 1.000 49.90190  ? 108 HOH B O   1 
# 
