data_8XTC
# 
_entry.id   8XTC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XTC         pdb_00008xtc 10.2210/pdb8xtc/pdb 
WWPDB D_1300044107 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'Structure model' 1 1 2025-02-19 ? 
3 'Structure model' 1 2 2025-04-16 ? 
4 'Structure model' 1 3 2025-04-30 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
3 4 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
4 3 'Structure model' citation_author 
5 4 'Structure model' citation        
6 4 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.page_first'              
6  2 'Structure model' '_citation.page_last'               
7  2 'Structure model' '_citation.pdbx_database_id_DOI'    
8  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
9  2 'Structure model' '_citation.title'                   
10 2 'Structure model' '_citation.year'                    
11 3 'Structure model' '_citation.journal_volume'          
12 3 'Structure model' '_citation.page_first'              
13 3 'Structure model' '_citation.page_last'               
14 3 'Structure model' '_citation_author.identifier_ORCID' 
15 4 'Structure model' '_citation.page_first'              
16 4 'Structure model' '_citation.page_last'               
17 4 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XTC 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              liu_wd@tib.cas.cn 
_pdbx_contact_author.name_first         Weidong 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7954-7700 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Cong, L.'          1 ? 
'Li, Z.S.'          2 ? 
'Zheng, Z.R.'       3 ? 
'Han, X.'           4 ? 
'Gert, W.'          5 ? 
'Wei, R.'           6 ? 
'Liu, W.D.'         7 ? 
'Bornscheuer, U.T.' 8 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   DE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Adv Sci' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2198-3844 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            12 
_citation.language                  ? 
_citation.page_first                e2416019 
_citation.page_last                 e2416019 
_citation.title                     
'Structure-Guided Engineering of a Versatile Urethanase Improves Its Polyurethane Depolymerization Activity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/advs.202416019 
_citation.pdbx_database_id_PubMed   39921299 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, Z.'            1  ?                   
primary 'Han, X.'           2  ?                   
primary 'Cong, L.'          3  ?                   
primary 'Singh, P.'         4  ?                   
primary 'Paiva, P.'         5  0000-0002-7003-6055 
primary 'Branson, Y.'       6  0000-0002-0282-7090 
primary 'Li, W.'            7  ?                   
primary 'Chen, Y.'          8  ?                   
primary 'Jaradat, D.M.M.'   9  ?                   
primary 'Lennartz, F.'      10 ?                   
primary 'Bayer, T.'         11 0000-0002-0656-3280 
primary 'Schmidt, L.'       12 ?                   
primary 'Garscha, U.'       13 ?                   
primary 'You, S.'           14 ?                   
primary 'Fernandes, P.A.'   15 0000-0003-2748-4722 
primary 'Ramos, M.J.'       16 0000-0002-7554-8324 
primary 'Bornscheuer, U.T.' 17 0000-0003-0685-2696 
primary 'Weber, G.'         18 0000-0003-3624-1060 
primary 'Wei, R.'           19 0000-0003-3876-1350 
primary 'Liu, W.'           20 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man umgsp2-mut                                      47028.090 2   ? ? ? ? 
2 non-polymer syn '4-oxidanylbutyl ~{N}-(4-aminophenyl)carbamate' 224.256   3   ? ? ? ? 
3 non-polymer nat GLYCEROL                                        92.094    2   ? ? ? ? 
4 water       nat water                                           18.015    384 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;NLYFQGAGAGAGAGAMSELSAIETAAAIAGGSMTALEACDAAIARIEQRDGPINAVVVRDFDRARDAAKAADAEIAAAVR
KPLLGVPMTIKESFDIAGLPTSWGFAEHADHIATADSLVVSRLKAAGAVFLGKSNIPVGLADWQSVNPNYGRTNNPHDHS
RSAGGSSGGAAAALAAGMVPLEYGSDIGGAIRVPAHFCGVWGLKTTFDAVSLEGHYFPRTDSAKADLSVVGPMARTPADL
ALALDITSKVPLPQSRIANLSGLRILLLTAHPETVADSATISAVERAAAACEASGATVATSSPDLPDLSALVADYTRMLL
VVLARGLAPEGTEPVSLNAWYAMLDDQARMMRAFDRLFESFDAIFCPVLGTTAFAHSDEPDWAKRSLSIDGGIAPFAAQL
GWISMATYGGMPALSMPLGADGNGLPINLQIITRNWSDHDAIRIGALVAEALDR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;NLYFQGAGAGAGAGAMSELSAIETAAAIAGGSMTALEACDAAIARIEQRDGPINAVVVRDFDRARDAAKAADAEIAAAVR
KPLLGVPMTIKESFDIAGLPTSWGFAEHADHIATADSLVVSRLKAAGAVFLGKSNIPVGLADWQSVNPNYGRTNNPHDHS
RSAGGSSGGAAAALAAGMVPLEYGSDIGGAIRVPAHFCGVWGLKTTFDAVSLEGHYFPRTDSAKADLSVVGPMARTPADL
ALALDITSKVPLPQSRIANLSGLRILLLTAHPETVADSATISAVERAAAACEASGATVATSSPDLPDLSALVADYTRMLL
VVLARGLAPEGTEPVSLNAWYAMLDDQARMMRAFDRLFESFDAIFCPVLGTTAFAHSDEPDWAKRSLSIDGGIAPFAAQL
GWISMATYGGMPALSMPLGADGNGLPINLQIITRNWSDHDAIRIGALVAEALDR
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '4-oxidanylbutyl ~{N}-(4-aminophenyl)carbamate' A1D5H 
3 GLYCEROL                                        GOL   
4 water                                           HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASN n 
1 2   LEU n 
1 3   TYR n 
1 4   PHE n 
1 5   GLN n 
1 6   GLY n 
1 7   ALA n 
1 8   GLY n 
1 9   ALA n 
1 10  GLY n 
1 11  ALA n 
1 12  GLY n 
1 13  ALA n 
1 14  GLY n 
1 15  ALA n 
1 16  MET n 
1 17  SER n 
1 18  GLU n 
1 19  LEU n 
1 20  SER n 
1 21  ALA n 
1 22  ILE n 
1 23  GLU n 
1 24  THR n 
1 25  ALA n 
1 26  ALA n 
1 27  ALA n 
1 28  ILE n 
1 29  ALA n 
1 30  GLY n 
1 31  GLY n 
1 32  SER n 
1 33  MET n 
1 34  THR n 
1 35  ALA n 
1 36  LEU n 
1 37  GLU n 
1 38  ALA n 
1 39  CYS n 
1 40  ASP n 
1 41  ALA n 
1 42  ALA n 
1 43  ILE n 
1 44  ALA n 
1 45  ARG n 
1 46  ILE n 
1 47  GLU n 
1 48  GLN n 
1 49  ARG n 
1 50  ASP n 
1 51  GLY n 
1 52  PRO n 
1 53  ILE n 
1 54  ASN n 
1 55  ALA n 
1 56  VAL n 
1 57  VAL n 
1 58  VAL n 
1 59  ARG n 
1 60  ASP n 
1 61  PHE n 
1 62  ASP n 
1 63  ARG n 
1 64  ALA n 
1 65  ARG n 
1 66  ASP n 
1 67  ALA n 
1 68  ALA n 
1 69  LYS n 
1 70  ALA n 
1 71  ALA n 
1 72  ASP n 
1 73  ALA n 
1 74  GLU n 
1 75  ILE n 
1 76  ALA n 
1 77  ALA n 
1 78  ALA n 
1 79  VAL n 
1 80  ARG n 
1 81  LYS n 
1 82  PRO n 
1 83  LEU n 
1 84  LEU n 
1 85  GLY n 
1 86  VAL n 
1 87  PRO n 
1 88  MET n 
1 89  THR n 
1 90  ILE n 
1 91  LYS n 
1 92  GLU n 
1 93  SER n 
1 94  PHE n 
1 95  ASP n 
1 96  ILE n 
1 97  ALA n 
1 98  GLY n 
1 99  LEU n 
1 100 PRO n 
1 101 THR n 
1 102 SER n 
1 103 TRP n 
1 104 GLY n 
1 105 PHE n 
1 106 ALA n 
1 107 GLU n 
1 108 HIS n 
1 109 ALA n 
1 110 ASP n 
1 111 HIS n 
1 112 ILE n 
1 113 ALA n 
1 114 THR n 
1 115 ALA n 
1 116 ASP n 
1 117 SER n 
1 118 LEU n 
1 119 VAL n 
1 120 VAL n 
1 121 SER n 
1 122 ARG n 
1 123 LEU n 
1 124 LYS n 
1 125 ALA n 
1 126 ALA n 
1 127 GLY n 
1 128 ALA n 
1 129 VAL n 
1 130 PHE n 
1 131 LEU n 
1 132 GLY n 
1 133 LYS n 
1 134 SER n 
1 135 ASN n 
1 136 ILE n 
1 137 PRO n 
1 138 VAL n 
1 139 GLY n 
1 140 LEU n 
1 141 ALA n 
1 142 ASP n 
1 143 TRP n 
1 144 GLN n 
1 145 SER n 
1 146 VAL n 
1 147 ASN n 
1 148 PRO n 
1 149 ASN n 
1 150 TYR n 
1 151 GLY n 
1 152 ARG n 
1 153 THR n 
1 154 ASN n 
1 155 ASN n 
1 156 PRO n 
1 157 HIS n 
1 158 ASP n 
1 159 HIS n 
1 160 SER n 
1 161 ARG n 
1 162 SER n 
1 163 ALA n 
1 164 GLY n 
1 165 GLY n 
1 166 SER n 
1 167 SER n 
1 168 GLY n 
1 169 GLY n 
1 170 ALA n 
1 171 ALA n 
1 172 ALA n 
1 173 ALA n 
1 174 LEU n 
1 175 ALA n 
1 176 ALA n 
1 177 GLY n 
1 178 MET n 
1 179 VAL n 
1 180 PRO n 
1 181 LEU n 
1 182 GLU n 
1 183 TYR n 
1 184 GLY n 
1 185 SER n 
1 186 ASP n 
1 187 ILE n 
1 188 GLY n 
1 189 GLY n 
1 190 ALA n 
1 191 ILE n 
1 192 ARG n 
1 193 VAL n 
1 194 PRO n 
1 195 ALA n 
1 196 HIS n 
1 197 PHE n 
1 198 CYS n 
1 199 GLY n 
1 200 VAL n 
1 201 TRP n 
1 202 GLY n 
1 203 LEU n 
1 204 LYS n 
1 205 THR n 
1 206 THR n 
1 207 PHE n 
1 208 ASP n 
1 209 ALA n 
1 210 VAL n 
1 211 SER n 
1 212 LEU n 
1 213 GLU n 
1 214 GLY n 
1 215 HIS n 
1 216 TYR n 
1 217 PHE n 
1 218 PRO n 
1 219 ARG n 
1 220 THR n 
1 221 ASP n 
1 222 SER n 
1 223 ALA n 
1 224 LYS n 
1 225 ALA n 
1 226 ASP n 
1 227 LEU n 
1 228 SER n 
1 229 VAL n 
1 230 VAL n 
1 231 GLY n 
1 232 PRO n 
1 233 MET n 
1 234 ALA n 
1 235 ARG n 
1 236 THR n 
1 237 PRO n 
1 238 ALA n 
1 239 ASP n 
1 240 LEU n 
1 241 ALA n 
1 242 LEU n 
1 243 ALA n 
1 244 LEU n 
1 245 ASP n 
1 246 ILE n 
1 247 THR n 
1 248 SER n 
1 249 LYS n 
1 250 VAL n 
1 251 PRO n 
1 252 LEU n 
1 253 PRO n 
1 254 GLN n 
1 255 SER n 
1 256 ARG n 
1 257 ILE n 
1 258 ALA n 
1 259 ASN n 
1 260 LEU n 
1 261 SER n 
1 262 GLY n 
1 263 LEU n 
1 264 ARG n 
1 265 ILE n 
1 266 LEU n 
1 267 LEU n 
1 268 LEU n 
1 269 THR n 
1 270 ALA n 
1 271 HIS n 
1 272 PRO n 
1 273 GLU n 
1 274 THR n 
1 275 VAL n 
1 276 ALA n 
1 277 ASP n 
1 278 SER n 
1 279 ALA n 
1 280 THR n 
1 281 ILE n 
1 282 SER n 
1 283 ALA n 
1 284 VAL n 
1 285 GLU n 
1 286 ARG n 
1 287 ALA n 
1 288 ALA n 
1 289 ALA n 
1 290 ALA n 
1 291 CYS n 
1 292 GLU n 
1 293 ALA n 
1 294 SER n 
1 295 GLY n 
1 296 ALA n 
1 297 THR n 
1 298 VAL n 
1 299 ALA n 
1 300 THR n 
1 301 SER n 
1 302 SER n 
1 303 PRO n 
1 304 ASP n 
1 305 LEU n 
1 306 PRO n 
1 307 ASP n 
1 308 LEU n 
1 309 SER n 
1 310 ALA n 
1 311 LEU n 
1 312 VAL n 
1 313 ALA n 
1 314 ASP n 
1 315 TYR n 
1 316 THR n 
1 317 ARG n 
1 318 MET n 
1 319 LEU n 
1 320 LEU n 
1 321 VAL n 
1 322 VAL n 
1 323 LEU n 
1 324 ALA n 
1 325 ARG n 
1 326 GLY n 
1 327 LEU n 
1 328 ALA n 
1 329 PRO n 
1 330 GLU n 
1 331 GLY n 
1 332 THR n 
1 333 GLU n 
1 334 PRO n 
1 335 VAL n 
1 336 SER n 
1 337 LEU n 
1 338 ASN n 
1 339 ALA n 
1 340 TRP n 
1 341 TYR n 
1 342 ALA n 
1 343 MET n 
1 344 LEU n 
1 345 ASP n 
1 346 ASP n 
1 347 GLN n 
1 348 ALA n 
1 349 ARG n 
1 350 MET n 
1 351 MET n 
1 352 ARG n 
1 353 ALA n 
1 354 PHE n 
1 355 ASP n 
1 356 ARG n 
1 357 LEU n 
1 358 PHE n 
1 359 GLU n 
1 360 SER n 
1 361 PHE n 
1 362 ASP n 
1 363 ALA n 
1 364 ILE n 
1 365 PHE n 
1 366 CYS n 
1 367 PRO n 
1 368 VAL n 
1 369 LEU n 
1 370 GLY n 
1 371 THR n 
1 372 THR n 
1 373 ALA n 
1 374 PHE n 
1 375 ALA n 
1 376 HIS n 
1 377 SER n 
1 378 ASP n 
1 379 GLU n 
1 380 PRO n 
1 381 ASP n 
1 382 TRP n 
1 383 ALA n 
1 384 LYS n 
1 385 ARG n 
1 386 SER n 
1 387 LEU n 
1 388 SER n 
1 389 ILE n 
1 390 ASP n 
1 391 GLY n 
1 392 GLY n 
1 393 ILE n 
1 394 ALA n 
1 395 PRO n 
1 396 PHE n 
1 397 ALA n 
1 398 ALA n 
1 399 GLN n 
1 400 LEU n 
1 401 GLY n 
1 402 TRP n 
1 403 ILE n 
1 404 SER n 
1 405 MET n 
1 406 ALA n 
1 407 THR n 
1 408 TYR n 
1 409 GLY n 
1 410 GLY n 
1 411 MET n 
1 412 PRO n 
1 413 ALA n 
1 414 LEU n 
1 415 SER n 
1 416 MET n 
1 417 PRO n 
1 418 LEU n 
1 419 GLY n 
1 420 ALA n 
1 421 ASP n 
1 422 GLY n 
1 423 ASN n 
1 424 GLY n 
1 425 LEU n 
1 426 PRO n 
1 427 ILE n 
1 428 ASN n 
1 429 LEU n 
1 430 GLN n 
1 431 ILE n 
1 432 ILE n 
1 433 THR n 
1 434 ARG n 
1 435 ASN n 
1 436 TRP n 
1 437 SER n 
1 438 ASP n 
1 439 HIS n 
1 440 ASP n 
1 441 ALA n 
1 442 ILE n 
1 443 ARG n 
1 444 ILE n 
1 445 GLY n 
1 446 ALA n 
1 447 LEU n 
1 448 VAL n 
1 449 ALA n 
1 450 GLU n 
1 451 ALA n 
1 452 LEU n 
1 453 ASP n 
1 454 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   454 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      metagenome 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     256318 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D5H non-polymer         . '4-oxidanylbutyl ~{N}-(4-aminophenyl)carbamate' ?                               'C11 H16 N2 O3'  
224.256 
ALA   'L-peptide linking' y ALANINE                                         ?                               'C3 H7 N O2'     
89.093  
ARG   'L-peptide linking' y ARGININE                                        ?                               'C6 H15 N4 O2 1' 
175.209 
ASN   'L-peptide linking' y ASPARAGINE                                      ?                               'C4 H8 N2 O3'    
132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                 ?                               'C4 H7 N O4'     
133.103 
CYS   'L-peptide linking' y CYSTEINE                                        ?                               'C3 H7 N O2 S'   
121.158 
GLN   'L-peptide linking' y GLUTAMINE                                       ?                               'C5 H10 N2 O3'   
146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                 ?                               'C5 H9 N O4'     
147.129 
GLY   'peptide linking'   y GLYCINE                                         ?                               'C2 H5 N O2'     
75.067  
GOL   non-polymer         . GLYCEROL                                        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       
92.094  
HIS   'L-peptide linking' y HISTIDINE                                       ?                               'C6 H10 N3 O2 1' 
156.162 
HOH   non-polymer         . WATER                                           ?                               'H2 O'           
18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                      ?                               'C6 H13 N O2'    
131.173 
LEU   'L-peptide linking' y LEUCINE                                         ?                               'C6 H13 N O2'    
131.173 
LYS   'L-peptide linking' y LYSINE                                          ?                               'C6 H15 N2 O2 1' 
147.195 
MET   'L-peptide linking' y METHIONINE                                      ?                               'C5 H11 N O2 S'  
149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                   ?                               'C9 H11 N O2'    
165.189 
PRO   'L-peptide linking' y PROLINE                                         ?                               'C5 H9 N O2'     
115.130 
SER   'L-peptide linking' y SERINE                                          ?                               'C3 H7 N O3'     
105.093 
THR   'L-peptide linking' y THREONINE                                       ?                               'C4 H9 N O3'     
119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                      ?                               'C11 H12 N2 O2'  
204.225 
TYR   'L-peptide linking' y TYROSINE                                        ?                               'C9 H11 N O3'    
181.189 
VAL   'L-peptide linking' y VALINE                                          ?                               'C5 H11 N O2'    
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASN 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   TYR 3   3   ?   ?   ?   A . n 
A 1 4   PHE 4   4   ?   ?   ?   A . n 
A 1 5   GLN 5   5   ?   ?   ?   A . n 
A 1 6   GLY 6   6   ?   ?   ?   A . n 
A 1 7   ALA 7   7   ?   ?   ?   A . n 
A 1 8   GLY 8   8   ?   ?   ?   A . n 
A 1 9   ALA 9   9   ?   ?   ?   A . n 
A 1 10  GLY 10  10  ?   ?   ?   A . n 
A 1 11  ALA 11  11  ?   ?   ?   A . n 
A 1 12  GLY 12  12  ?   ?   ?   A . n 
A 1 13  ALA 13  13  ?   ?   ?   A . n 
A 1 14  GLY 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  15  ALA ALA A . n 
A 1 16  MET 16  16  16  MET MET A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  GLU 18  18  18  GLU GLU A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  ALA 21  21  21  ALA ALA A . n 
A 1 22  ILE 22  22  22  ILE ILE A . n 
A 1 23  GLU 23  23  23  GLU GLU A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  ALA 25  25  25  ALA ALA A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  ALA 27  27  27  ALA ALA A . n 
A 1 28  ILE 28  28  28  ILE ILE A . n 
A 1 29  ALA 29  29  29  ALA ALA A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  GLY 31  31  31  GLY GLY A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  MET 33  33  33  MET MET A . n 
A 1 34  THR 34  34  34  THR THR A . n 
A 1 35  ALA 35  35  35  ALA ALA A . n 
A 1 36  LEU 36  36  36  LEU LEU A . n 
A 1 37  GLU 37  37  37  GLU GLU A . n 
A 1 38  ALA 38  38  38  ALA ALA A . n 
A 1 39  CYS 39  39  39  CYS CYS A . n 
A 1 40  ASP 40  40  40  ASP ASP A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  ARG 45  45  45  ARG ARG A . n 
A 1 46  ILE 46  46  46  ILE ILE A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  GLN 48  48  48  GLN GLN A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  ASP 50  50  50  ASP ASP A . n 
A 1 51  GLY 51  51  51  GLY GLY A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ILE 53  53  53  ILE ILE A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  VAL 57  57  57  VAL VAL A . n 
A 1 58  VAL 58  58  58  VAL VAL A . n 
A 1 59  ARG 59  59  59  ARG ARG A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  PHE 61  61  61  PHE PHE A . n 
A 1 62  ASP 62  62  62  ASP ASP A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  ARG 65  65  65  ARG ARG A . n 
A 1 66  ASP 66  66  66  ASP ASP A . n 
A 1 67  ALA 67  67  67  ALA ALA A . n 
A 1 68  ALA 68  68  68  ALA ALA A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  ALA 71  71  71  ALA ALA A . n 
A 1 72  ASP 72  72  72  ASP ASP A . n 
A 1 73  ALA 73  73  73  ALA ALA A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  ILE 75  75  75  ILE ILE A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  LYS 81  81  81  LYS LYS A . n 
A 1 82  PRO 82  82  82  PRO PRO A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  MET 88  88  88  MET MET A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  LYS 91  91  91  LYS LYS A . n 
A 1 92  GLU 92  92  92  GLU GLU A . n 
A 1 93  SER 93  93  93  SER SER A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  ILE 96  96  96  ILE ILE A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  GLY 98  98  98  GLY GLY A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 PRO 100 100 100 PRO PRO A . n 
A 1 101 THR 101 101 101 THR THR A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 TRP 103 103 103 TRP TRP A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 GLU 107 107 107 GLU GLU A . n 
A 1 108 HIS 108 108 108 HIS HIS A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 HIS 111 111 111 HIS HIS A . n 
A 1 112 ILE 112 112 112 ILE ILE A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 THR 114 114 114 THR THR A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 ALA 128 128 128 ALA ALA A . n 
A 1 129 VAL 129 129 129 VAL VAL A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 SER 134 134 134 SER SER A . n 
A 1 135 ASN 135 135 135 ASN ASN A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 PRO 137 137 137 PRO PRO A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 GLY 139 139 139 GLY GLY A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 ALA 141 141 141 ALA ALA A . n 
A 1 142 ASP 142 142 142 ASP ASP A . n 
A 1 143 TRP 143 143 143 TRP TRP A . n 
A 1 144 GLN 144 144 144 GLN GLN A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 VAL 146 146 146 VAL VAL A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 PRO 148 148 148 PRO PRO A . n 
A 1 149 ASN 149 149 149 ASN ASN A . n 
A 1 150 TYR 150 150 150 TYR TYR A . n 
A 1 151 GLY 151 151 151 GLY GLY A . n 
A 1 152 ARG 152 152 152 ARG ARG A . n 
A 1 153 THR 153 153 153 THR THR A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 ASN 155 155 155 ASN ASN A . n 
A 1 156 PRO 156 156 156 PRO PRO A . n 
A 1 157 HIS 157 157 157 HIS HIS A . n 
A 1 158 ASP 158 158 158 ASP ASP A . n 
A 1 159 HIS 159 159 159 HIS HIS A . n 
A 1 160 SER 160 160 160 SER SER A . n 
A 1 161 ARG 161 161 161 ARG ARG A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ALA 163 163 163 ALA ALA A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 SER 166 166 166 SER SER A . n 
A 1 167 SER 167 167 167 SER SER A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 ALA 170 170 170 ALA ALA A . n 
A 1 171 ALA 171 171 171 ALA ALA A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 MET 178 178 178 MET MET A . n 
A 1 179 VAL 179 179 179 VAL VAL A . n 
A 1 180 PRO 180 180 180 PRO PRO A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 TYR 183 183 183 TYR TYR A . n 
A 1 184 GLY 184 184 184 GLY GLY A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 ILE 187 187 187 ILE ILE A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 GLY 189 189 189 GLY GLY A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 ILE 191 191 191 ILE ILE A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 VAL 193 193 193 VAL VAL A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 ALA 195 195 195 ALA ALA A . n 
A 1 196 HIS 196 196 196 HIS HIS A . n 
A 1 197 PHE 197 197 197 PHE PHE A . n 
A 1 198 CYS 198 198 198 CYS CYS A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 VAL 200 200 200 VAL VAL A . n 
A 1 201 TRP 201 201 201 TRP TRP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 LEU 203 203 203 LEU LEU A . n 
A 1 204 LYS 204 204 204 LYS LYS A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 THR 206 206 206 THR THR A . n 
A 1 207 PHE 207 207 207 PHE PHE A . n 
A 1 208 ASP 208 208 208 ASP ASP A . n 
A 1 209 ALA 209 209 209 ALA ALA A . n 
A 1 210 VAL 210 210 210 VAL VAL A . n 
A 1 211 SER 211 211 211 SER SER A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 GLY 214 214 214 GLY GLY A . n 
A 1 215 HIS 215 215 215 HIS HIS A . n 
A 1 216 TYR 216 216 216 TYR TYR A . n 
A 1 217 PHE 217 217 217 PHE PHE A . n 
A 1 218 PRO 218 218 218 PRO PRO A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 THR 220 220 220 THR THR A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 LYS 224 224 224 LYS LYS A . n 
A 1 225 ALA 225 225 225 ALA ALA A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 SER 228 228 228 SER SER A . n 
A 1 229 VAL 229 229 229 VAL VAL A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 GLY 231 231 231 GLY GLY A . n 
A 1 232 PRO 232 232 232 PRO PRO A . n 
A 1 233 MET 233 233 233 MET MET A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 ARG 235 235 235 ARG ARG A . n 
A 1 236 THR 236 236 236 THR THR A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 ASP 239 239 239 ASP ASP A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 LEU 244 244 244 LEU LEU A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 ILE 246 246 246 ILE ILE A . n 
A 1 247 THR 247 247 247 THR THR A . n 
A 1 248 SER 248 248 248 SER SER A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 VAL 250 250 250 VAL VAL A . n 
A 1 251 PRO 251 251 251 PRO PRO A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 GLN 254 254 254 GLN GLN A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ALA 258 258 258 ALA ALA A . n 
A 1 259 ASN 259 259 259 ASN ASN A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 SER 261 261 261 SER SER A . n 
A 1 262 GLY 262 262 262 GLY GLY A . n 
A 1 263 LEU 263 263 263 LEU LEU A . n 
A 1 264 ARG 264 264 264 ARG ARG A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 LEU 267 267 267 LEU LEU A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 THR 269 269 269 THR THR A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 HIS 271 271 271 HIS HIS A . n 
A 1 272 PRO 272 272 272 PRO PRO A . n 
A 1 273 GLU 273 273 273 GLU GLU A . n 
A 1 274 THR 274 274 274 THR THR A . n 
A 1 275 VAL 275 275 275 VAL VAL A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 ASP 277 277 277 ASP ASP A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 ALA 279 279 279 ALA ALA A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 SER 282 282 282 SER SER A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 GLU 285 285 285 GLU GLU A . n 
A 1 286 ARG 286 286 286 ARG ARG A . n 
A 1 287 ALA 287 287 287 ALA ALA A . n 
A 1 288 ALA 288 288 288 ALA ALA A . n 
A 1 289 ALA 289 289 289 ALA ALA A . n 
A 1 290 ALA 290 290 290 ALA ALA A . n 
A 1 291 CYS 291 291 291 CYS CYS A . n 
A 1 292 GLU 292 292 292 GLU GLU A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 THR 297 297 297 THR THR A . n 
A 1 298 VAL 298 298 298 VAL VAL A . n 
A 1 299 ALA 299 299 299 ALA ALA A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 SER 302 302 302 SER SER A . n 
A 1 303 PRO 303 303 303 PRO PRO A . n 
A 1 304 ASP 304 304 304 ASP ASP A . n 
A 1 305 LEU 305 305 305 LEU LEU A . n 
A 1 306 PRO 306 306 306 PRO PRO A . n 
A 1 307 ASP 307 307 307 ASP ASP A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 SER 309 309 309 SER SER A . n 
A 1 310 ALA 310 310 310 ALA ALA A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 VAL 312 312 312 VAL VAL A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 ASP 314 314 314 ASP ASP A . n 
A 1 315 TYR 315 315 315 TYR TYR A . n 
A 1 316 THR 316 316 316 THR THR A . n 
A 1 317 ARG 317 317 317 ARG ARG A . n 
A 1 318 MET 318 318 318 MET MET A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 LEU 320 320 320 LEU LEU A . n 
A 1 321 VAL 321 321 321 VAL VAL A . n 
A 1 322 VAL 322 322 322 VAL VAL A . n 
A 1 323 LEU 323 323 323 LEU LEU A . n 
A 1 324 ALA 324 324 324 ALA ALA A . n 
A 1 325 ARG 325 325 325 ARG ARG A . n 
A 1 326 GLY 326 326 326 GLY GLY A . n 
A 1 327 LEU 327 327 327 LEU LEU A . n 
A 1 328 ALA 328 328 328 ALA ALA A . n 
A 1 329 PRO 329 329 329 PRO PRO A . n 
A 1 330 GLU 330 330 330 GLU GLU A . n 
A 1 331 GLY 331 331 331 GLY GLY A . n 
A 1 332 THR 332 332 332 THR THR A . n 
A 1 333 GLU 333 333 333 GLU GLU A . n 
A 1 334 PRO 334 334 334 PRO PRO A . n 
A 1 335 VAL 335 335 335 VAL VAL A . n 
A 1 336 SER 336 336 336 SER SER A . n 
A 1 337 LEU 337 337 337 LEU LEU A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 ALA 339 339 339 ALA ALA A . n 
A 1 340 TRP 340 340 340 TRP TRP A . n 
A 1 341 TYR 341 341 341 TYR TYR A . n 
A 1 342 ALA 342 342 342 ALA ALA A . n 
A 1 343 MET 343 343 343 MET MET A . n 
A 1 344 LEU 344 344 344 LEU LEU A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ASP 346 346 346 ASP ASP A . n 
A 1 347 GLN 347 347 347 GLN GLN A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 ARG 349 349 349 ARG ARG A . n 
A 1 350 MET 350 350 350 MET MET A . n 
A 1 351 MET 351 351 351 MET MET A . n 
A 1 352 ARG 352 352 352 ARG ARG A . n 
A 1 353 ALA 353 353 353 ALA ALA A . n 
A 1 354 PHE 354 354 354 PHE PHE A . n 
A 1 355 ASP 355 355 355 ASP ASP A . n 
A 1 356 ARG 356 356 356 ARG ARG A . n 
A 1 357 LEU 357 357 357 LEU LEU A . n 
A 1 358 PHE 358 358 358 PHE PHE A . n 
A 1 359 GLU 359 359 359 GLU GLU A . n 
A 1 360 SER 360 360 360 SER SER A . n 
A 1 361 PHE 361 361 361 PHE PHE A . n 
A 1 362 ASP 362 362 362 ASP ASP A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 ILE 364 364 364 ILE ILE A . n 
A 1 365 PHE 365 365 365 PHE PHE A . n 
A 1 366 CYS 366 366 366 CYS CYS A . n 
A 1 367 PRO 367 367 367 PRO PRO A . n 
A 1 368 VAL 368 368 368 VAL VAL A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 GLY 370 370 370 GLY GLY A . n 
A 1 371 THR 371 371 371 THR THR A . n 
A 1 372 THR 372 372 372 THR THR A . n 
A 1 373 ALA 373 373 373 ALA ALA A . n 
A 1 374 PHE 374 374 374 PHE PHE A . n 
A 1 375 ALA 375 375 375 ALA ALA A . n 
A 1 376 HIS 376 376 376 HIS HIS A . n 
A 1 377 SER 377 377 377 SER SER A . n 
A 1 378 ASP 378 378 378 ASP ASP A . n 
A 1 379 GLU 379 379 379 GLU GLU A . n 
A 1 380 PRO 380 380 380 PRO PRO A . n 
A 1 381 ASP 381 381 381 ASP ASP A . n 
A 1 382 TRP 382 382 382 TRP TRP A . n 
A 1 383 ALA 383 383 383 ALA ALA A . n 
A 1 384 LYS 384 384 384 LYS LYS A . n 
A 1 385 ARG 385 385 385 ARG ARG A . n 
A 1 386 SER 386 386 386 SER SER A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 SER 388 388 388 SER SER A . n 
A 1 389 ILE 389 389 389 ILE ILE A . n 
A 1 390 ASP 390 390 390 ASP ASP A . n 
A 1 391 GLY 391 391 391 GLY GLY A . n 
A 1 392 GLY 392 392 392 GLY GLY A . n 
A 1 393 ILE 393 393 393 ILE ILE A . n 
A 1 394 ALA 394 394 394 ALA ALA A . n 
A 1 395 PRO 395 395 395 PRO PRO A . n 
A 1 396 PHE 396 396 396 PHE PHE A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 ALA 398 398 398 ALA ALA A . n 
A 1 399 GLN 399 399 399 GLN GLN A . n 
A 1 400 LEU 400 400 400 LEU LEU A . n 
A 1 401 GLY 401 401 401 GLY GLY A . n 
A 1 402 TRP 402 402 402 TRP TRP A . n 
A 1 403 ILE 403 403 403 ILE ILE A . n 
A 1 404 SER 404 404 404 SER SER A . n 
A 1 405 MET 405 405 405 MET MET A . n 
A 1 406 ALA 406 406 406 ALA ALA A . n 
A 1 407 THR 407 407 407 THR THR A . n 
A 1 408 TYR 408 408 408 TYR TYR A . n 
A 1 409 GLY 409 409 409 GLY GLY A . n 
A 1 410 GLY 410 410 410 GLY GLY A . n 
A 1 411 MET 411 411 411 MET MET A . n 
A 1 412 PRO 412 412 412 PRO PRO A . n 
A 1 413 ALA 413 413 413 ALA ALA A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 SER 415 415 415 SER SER A . n 
A 1 416 MET 416 416 416 MET MET A . n 
A 1 417 PRO 417 417 417 PRO PRO A . n 
A 1 418 LEU 418 418 418 LEU LEU A . n 
A 1 419 GLY 419 419 419 GLY GLY A . n 
A 1 420 ALA 420 420 420 ALA ALA A . n 
A 1 421 ASP 421 421 421 ASP ASP A . n 
A 1 422 GLY 422 422 422 GLY GLY A . n 
A 1 423 ASN 423 423 423 ASN ASN A . n 
A 1 424 GLY 424 424 424 GLY GLY A . n 
A 1 425 LEU 425 425 425 LEU LEU A . n 
A 1 426 PRO 426 426 426 PRO PRO A . n 
A 1 427 ILE 427 427 427 ILE ILE A . n 
A 1 428 ASN 428 428 428 ASN ASN A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 GLN 430 430 430 GLN GLN A . n 
A 1 431 ILE 431 431 431 ILE ILE A . n 
A 1 432 ILE 432 432 432 ILE ILE A . n 
A 1 433 THR 433 433 433 THR THR A . n 
A 1 434 ARG 434 434 434 ARG ARG A . n 
A 1 435 ASN 435 435 435 ASN ASN A . n 
A 1 436 TRP 436 436 436 TRP TRP A . n 
A 1 437 SER 437 437 437 SER SER A . n 
A 1 438 ASP 438 438 438 ASP ASP A . n 
A 1 439 HIS 439 439 439 HIS HIS A . n 
A 1 440 ASP 440 440 440 ASP ASP A . n 
A 1 441 ALA 441 441 441 ALA ALA A . n 
A 1 442 ILE 442 442 442 ILE ILE A . n 
A 1 443 ARG 443 443 443 ARG ARG A . n 
A 1 444 ILE 444 444 444 ILE ILE A . n 
A 1 445 GLY 445 445 445 GLY GLY A . n 
A 1 446 ALA 446 446 446 ALA ALA A . n 
A 1 447 LEU 447 447 447 LEU LEU A . n 
A 1 448 VAL 448 448 448 VAL VAL A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 GLU 450 450 450 GLU GLU A . n 
A 1 451 ALA 451 451 451 ALA ALA A . n 
A 1 452 LEU 452 452 452 LEU LEU A . n 
A 1 453 ASP 453 453 453 ASP ASP A . n 
A 1 454 ARG 454 454 454 ARG ARG A . n 
B 1 1   ASN 1   1   ?   ?   ?   B . n 
B 1 2   LEU 2   2   ?   ?   ?   B . n 
B 1 3   TYR 3   3   ?   ?   ?   B . n 
B 1 4   PHE 4   4   ?   ?   ?   B . n 
B 1 5   GLN 5   5   ?   ?   ?   B . n 
B 1 6   GLY 6   6   ?   ?   ?   B . n 
B 1 7   ALA 7   7   ?   ?   ?   B . n 
B 1 8   GLY 8   8   ?   ?   ?   B . n 
B 1 9   ALA 9   9   ?   ?   ?   B . n 
B 1 10  GLY 10  10  ?   ?   ?   B . n 
B 1 11  ALA 11  11  ?   ?   ?   B . n 
B 1 12  GLY 12  12  ?   ?   ?   B . n 
B 1 13  ALA 13  13  ?   ?   ?   B . n 
B 1 14  GLY 14  14  ?   ?   ?   B . n 
B 1 15  ALA 15  15  ?   ?   ?   B . n 
B 1 16  MET 16  16  ?   ?   ?   B . n 
B 1 17  SER 17  17  ?   ?   ?   B . n 
B 1 18  GLU 18  18  18  GLU GLU B . n 
B 1 19  LEU 19  19  19  LEU LEU B . n 
B 1 20  SER 20  20  20  SER SER B . n 
B 1 21  ALA 21  21  21  ALA ALA B . n 
B 1 22  ILE 22  22  22  ILE ILE B . n 
B 1 23  GLU 23  23  23  GLU GLU B . n 
B 1 24  THR 24  24  24  THR THR B . n 
B 1 25  ALA 25  25  25  ALA ALA B . n 
B 1 26  ALA 26  26  26  ALA ALA B . n 
B 1 27  ALA 27  27  27  ALA ALA B . n 
B 1 28  ILE 28  28  28  ILE ILE B . n 
B 1 29  ALA 29  29  29  ALA ALA B . n 
B 1 30  GLY 30  30  30  GLY GLY B . n 
B 1 31  GLY 31  31  31  GLY GLY B . n 
B 1 32  SER 32  32  32  SER SER B . n 
B 1 33  MET 33  33  33  MET MET B . n 
B 1 34  THR 34  34  34  THR THR B . n 
B 1 35  ALA 35  35  35  ALA ALA B . n 
B 1 36  LEU 36  36  36  LEU LEU B . n 
B 1 37  GLU 37  37  37  GLU GLU B . n 
B 1 38  ALA 38  38  38  ALA ALA B . n 
B 1 39  CYS 39  39  39  CYS CYS B . n 
B 1 40  ASP 40  40  40  ASP ASP B . n 
B 1 41  ALA 41  41  41  ALA ALA B . n 
B 1 42  ALA 42  42  42  ALA ALA B . n 
B 1 43  ILE 43  43  43  ILE ILE B . n 
B 1 44  ALA 44  44  44  ALA ALA B . n 
B 1 45  ARG 45  45  45  ARG ARG B . n 
B 1 46  ILE 46  46  46  ILE ILE B . n 
B 1 47  GLU 47  47  47  GLU GLU B . n 
B 1 48  GLN 48  48  48  GLN GLN B . n 
B 1 49  ARG 49  49  49  ARG ARG B . n 
B 1 50  ASP 50  50  50  ASP ASP B . n 
B 1 51  GLY 51  51  51  GLY GLY B . n 
B 1 52  PRO 52  52  52  PRO PRO B . n 
B 1 53  ILE 53  53  53  ILE ILE B . n 
B 1 54  ASN 54  54  54  ASN ASN B . n 
B 1 55  ALA 55  55  55  ALA ALA B . n 
B 1 56  VAL 56  56  56  VAL VAL B . n 
B 1 57  VAL 57  57  57  VAL VAL B . n 
B 1 58  VAL 58  58  58  VAL VAL B . n 
B 1 59  ARG 59  59  59  ARG ARG B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  PHE 61  61  61  PHE PHE B . n 
B 1 62  ASP 62  62  62  ASP ASP B . n 
B 1 63  ARG 63  63  63  ARG ARG B . n 
B 1 64  ALA 64  64  64  ALA ALA B . n 
B 1 65  ARG 65  65  65  ARG ARG B . n 
B 1 66  ASP 66  66  66  ASP ASP B . n 
B 1 67  ALA 67  67  67  ALA ALA B . n 
B 1 68  ALA 68  68  68  ALA ALA B . n 
B 1 69  LYS 69  69  69  LYS LYS B . n 
B 1 70  ALA 70  70  70  ALA ALA B . n 
B 1 71  ALA 71  71  71  ALA ALA B . n 
B 1 72  ASP 72  72  72  ASP ASP B . n 
B 1 73  ALA 73  73  73  ALA ALA B . n 
B 1 74  GLU 74  74  74  GLU GLU B . n 
B 1 75  ILE 75  75  75  ILE ILE B . n 
B 1 76  ALA 76  76  76  ALA ALA B . n 
B 1 77  ALA 77  77  77  ALA ALA B . n 
B 1 78  ALA 78  78  78  ALA ALA B . n 
B 1 79  VAL 79  79  79  VAL VAL B . n 
B 1 80  ARG 80  80  80  ARG ARG B . n 
B 1 81  LYS 81  81  81  LYS LYS B . n 
B 1 82  PRO 82  82  82  PRO PRO B . n 
B 1 83  LEU 83  83  83  LEU LEU B . n 
B 1 84  LEU 84  84  84  LEU LEU B . n 
B 1 85  GLY 85  85  85  GLY GLY B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  PRO 87  87  87  PRO PRO B . n 
B 1 88  MET 88  88  88  MET MET B . n 
B 1 89  THR 89  89  89  THR THR B . n 
B 1 90  ILE 90  90  90  ILE ILE B . n 
B 1 91  LYS 91  91  91  LYS LYS B . n 
B 1 92  GLU 92  92  92  GLU GLU B . n 
B 1 93  SER 93  93  93  SER SER B . n 
B 1 94  PHE 94  94  94  PHE PHE B . n 
B 1 95  ASP 95  95  95  ASP ASP B . n 
B 1 96  ILE 96  96  96  ILE ILE B . n 
B 1 97  ALA 97  97  97  ALA ALA B . n 
B 1 98  GLY 98  98  98  GLY GLY B . n 
B 1 99  LEU 99  99  99  LEU LEU B . n 
B 1 100 PRO 100 100 100 PRO PRO B . n 
B 1 101 THR 101 101 101 THR THR B . n 
B 1 102 SER 102 102 102 SER SER B . n 
B 1 103 TRP 103 103 103 TRP TRP B . n 
B 1 104 GLY 104 104 104 GLY GLY B . n 
B 1 105 PHE 105 105 105 PHE PHE B . n 
B 1 106 ALA 106 106 106 ALA ALA B . n 
B 1 107 GLU 107 107 107 GLU GLU B . n 
B 1 108 HIS 108 108 108 HIS HIS B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 ASP 110 110 110 ASP ASP B . n 
B 1 111 HIS 111 111 111 HIS HIS B . n 
B 1 112 ILE 112 112 112 ILE ILE B . n 
B 1 113 ALA 113 113 113 ALA ALA B . n 
B 1 114 THR 114 114 114 THR THR B . n 
B 1 115 ALA 115 115 115 ALA ALA B . n 
B 1 116 ASP 116 116 116 ASP ASP B . n 
B 1 117 SER 117 117 117 SER SER B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 VAL 119 119 119 VAL VAL B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 ARG 122 122 122 ARG ARG B . n 
B 1 123 LEU 123 123 123 LEU LEU B . n 
B 1 124 LYS 124 124 124 LYS LYS B . n 
B 1 125 ALA 125 125 125 ALA ALA B . n 
B 1 126 ALA 126 126 126 ALA ALA B . n 
B 1 127 GLY 127 127 127 GLY GLY B . n 
B 1 128 ALA 128 128 128 ALA ALA B . n 
B 1 129 VAL 129 129 129 VAL VAL B . n 
B 1 130 PHE 130 130 130 PHE PHE B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 GLY 132 132 132 GLY GLY B . n 
B 1 133 LYS 133 133 133 LYS LYS B . n 
B 1 134 SER 134 134 134 SER SER B . n 
B 1 135 ASN 135 135 135 ASN ASN B . n 
B 1 136 ILE 136 136 136 ILE ILE B . n 
B 1 137 PRO 137 137 137 PRO PRO B . n 
B 1 138 VAL 138 138 138 VAL VAL B . n 
B 1 139 GLY 139 139 139 GLY GLY B . n 
B 1 140 LEU 140 140 140 LEU LEU B . n 
B 1 141 ALA 141 141 141 ALA ALA B . n 
B 1 142 ASP 142 142 142 ASP ASP B . n 
B 1 143 TRP 143 143 143 TRP TRP B . n 
B 1 144 GLN 144 144 144 GLN GLN B . n 
B 1 145 SER 145 145 145 SER SER B . n 
B 1 146 VAL 146 146 146 VAL VAL B . n 
B 1 147 ASN 147 147 147 ASN ASN B . n 
B 1 148 PRO 148 148 148 PRO PRO B . n 
B 1 149 ASN 149 149 149 ASN ASN B . n 
B 1 150 TYR 150 150 150 TYR TYR B . n 
B 1 151 GLY 151 151 151 GLY GLY B . n 
B 1 152 ARG 152 152 152 ARG ARG B . n 
B 1 153 THR 153 153 153 THR THR B . n 
B 1 154 ASN 154 154 154 ASN ASN B . n 
B 1 155 ASN 155 155 155 ASN ASN B . n 
B 1 156 PRO 156 156 156 PRO PRO B . n 
B 1 157 HIS 157 157 157 HIS HIS B . n 
B 1 158 ASP 158 158 158 ASP ASP B . n 
B 1 159 HIS 159 159 159 HIS HIS B . n 
B 1 160 SER 160 160 160 SER SER B . n 
B 1 161 ARG 161 161 161 ARG ARG B . n 
B 1 162 SER 162 162 162 SER SER B . n 
B 1 163 ALA 163 163 163 ALA ALA B . n 
B 1 164 GLY 164 164 164 GLY GLY B . n 
B 1 165 GLY 165 165 165 GLY GLY B . n 
B 1 166 SER 166 166 166 SER SER B . n 
B 1 167 SER 167 167 167 SER SER B . n 
B 1 168 GLY 168 168 168 GLY GLY B . n 
B 1 169 GLY 169 169 169 GLY GLY B . n 
B 1 170 ALA 170 170 170 ALA ALA B . n 
B 1 171 ALA 171 171 171 ALA ALA B . n 
B 1 172 ALA 172 172 172 ALA ALA B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 LEU 174 174 174 LEU LEU B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 ALA 176 176 176 ALA ALA B . n 
B 1 177 GLY 177 177 177 GLY GLY B . n 
B 1 178 MET 178 178 178 MET MET B . n 
B 1 179 VAL 179 179 179 VAL VAL B . n 
B 1 180 PRO 180 180 180 PRO PRO B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 TYR 183 183 183 TYR TYR B . n 
B 1 184 GLY 184 184 184 GLY GLY B . n 
B 1 185 SER 185 185 185 SER SER B . n 
B 1 186 ASP 186 186 186 ASP ASP B . n 
B 1 187 ILE 187 187 187 ILE ILE B . n 
B 1 188 GLY 188 188 188 GLY GLY B . n 
B 1 189 GLY 189 189 189 GLY GLY B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 ILE 191 191 191 ILE ILE B . n 
B 1 192 ARG 192 192 192 ARG ARG B . n 
B 1 193 VAL 193 193 193 VAL VAL B . n 
B 1 194 PRO 194 194 194 PRO PRO B . n 
B 1 195 ALA 195 195 195 ALA ALA B . n 
B 1 196 HIS 196 196 196 HIS HIS B . n 
B 1 197 PHE 197 197 197 PHE PHE B . n 
B 1 198 CYS 198 198 198 CYS CYS B . n 
B 1 199 GLY 199 199 199 GLY GLY B . n 
B 1 200 VAL 200 200 200 VAL VAL B . n 
B 1 201 TRP 201 201 201 TRP TRP B . n 
B 1 202 GLY 202 202 202 GLY GLY B . n 
B 1 203 LEU 203 203 203 LEU LEU B . n 
B 1 204 LYS 204 204 204 LYS LYS B . n 
B 1 205 THR 205 205 205 THR THR B . n 
B 1 206 THR 206 206 206 THR THR B . n 
B 1 207 PHE 207 207 207 PHE PHE B . n 
B 1 208 ASP 208 208 208 ASP ASP B . n 
B 1 209 ALA 209 209 209 ALA ALA B . n 
B 1 210 VAL 210 210 210 VAL VAL B . n 
B 1 211 SER 211 211 211 SER SER B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 GLU 213 213 213 GLU GLU B . n 
B 1 214 GLY 214 214 214 GLY GLY B . n 
B 1 215 HIS 215 215 215 HIS HIS B . n 
B 1 216 TYR 216 216 216 TYR TYR B . n 
B 1 217 PHE 217 217 217 PHE PHE B . n 
B 1 218 PRO 218 218 218 PRO PRO B . n 
B 1 219 ARG 219 219 219 ARG ARG B . n 
B 1 220 THR 220 220 220 THR THR B . n 
B 1 221 ASP 221 221 221 ASP ASP B . n 
B 1 222 SER 222 222 222 SER SER B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 LYS 224 224 224 LYS LYS B . n 
B 1 225 ALA 225 225 225 ALA ALA B . n 
B 1 226 ASP 226 226 226 ASP ASP B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 SER 228 228 228 SER SER B . n 
B 1 229 VAL 229 229 229 VAL VAL B . n 
B 1 230 VAL 230 230 230 VAL VAL B . n 
B 1 231 GLY 231 231 231 GLY GLY B . n 
B 1 232 PRO 232 232 232 PRO PRO B . n 
B 1 233 MET 233 233 233 MET MET B . n 
B 1 234 ALA 234 234 234 ALA ALA B . n 
B 1 235 ARG 235 235 235 ARG ARG B . n 
B 1 236 THR 236 236 236 THR THR B . n 
B 1 237 PRO 237 237 237 PRO PRO B . n 
B 1 238 ALA 238 238 238 ALA ALA B . n 
B 1 239 ASP 239 239 239 ASP ASP B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 ALA 241 241 241 ALA ALA B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 ALA 243 243 243 ALA ALA B . n 
B 1 244 LEU 244 244 244 LEU LEU B . n 
B 1 245 ASP 245 245 245 ASP ASP B . n 
B 1 246 ILE 246 246 246 ILE ILE B . n 
B 1 247 THR 247 247 247 THR THR B . n 
B 1 248 SER 248 248 248 SER SER B . n 
B 1 249 LYS 249 249 249 LYS LYS B . n 
B 1 250 VAL 250 250 250 VAL VAL B . n 
B 1 251 PRO 251 251 251 PRO PRO B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 PRO 253 253 253 PRO PRO B . n 
B 1 254 GLN 254 254 254 GLN GLN B . n 
B 1 255 SER 255 255 255 SER SER B . n 
B 1 256 ARG 256 256 256 ARG ARG B . n 
B 1 257 ILE 257 257 257 ILE ILE B . n 
B 1 258 ALA 258 258 258 ALA ALA B . n 
B 1 259 ASN 259 259 259 ASN ASN B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 SER 261 261 261 SER SER B . n 
B 1 262 GLY 262 262 262 GLY GLY B . n 
B 1 263 LEU 263 263 263 LEU LEU B . n 
B 1 264 ARG 264 264 264 ARG ARG B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 LEU 266 266 266 LEU LEU B . n 
B 1 267 LEU 267 267 267 LEU LEU B . n 
B 1 268 LEU 268 268 268 LEU LEU B . n 
B 1 269 THR 269 269 269 THR THR B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 HIS 271 271 271 HIS HIS B . n 
B 1 272 PRO 272 272 272 PRO PRO B . n 
B 1 273 GLU 273 273 273 GLU GLU B . n 
B 1 274 THR 274 274 274 THR THR B . n 
B 1 275 VAL 275 275 275 VAL VAL B . n 
B 1 276 ALA 276 276 276 ALA ALA B . n 
B 1 277 ASP 277 277 277 ASP ASP B . n 
B 1 278 SER 278 278 278 SER SER B . n 
B 1 279 ALA 279 279 279 ALA ALA B . n 
B 1 280 THR 280 280 280 THR THR B . n 
B 1 281 ILE 281 281 281 ILE ILE B . n 
B 1 282 SER 282 282 282 SER SER B . n 
B 1 283 ALA 283 283 283 ALA ALA B . n 
B 1 284 VAL 284 284 284 VAL VAL B . n 
B 1 285 GLU 285 285 285 GLU GLU B . n 
B 1 286 ARG 286 286 286 ARG ARG B . n 
B 1 287 ALA 287 287 287 ALA ALA B . n 
B 1 288 ALA 288 288 288 ALA ALA B . n 
B 1 289 ALA 289 289 289 ALA ALA B . n 
B 1 290 ALA 290 290 290 ALA ALA B . n 
B 1 291 CYS 291 291 291 CYS CYS B . n 
B 1 292 GLU 292 292 292 GLU GLU B . n 
B 1 293 ALA 293 293 293 ALA ALA B . n 
B 1 294 SER 294 294 294 SER SER B . n 
B 1 295 GLY 295 295 295 GLY GLY B . n 
B 1 296 ALA 296 296 296 ALA ALA B . n 
B 1 297 THR 297 297 297 THR THR B . n 
B 1 298 VAL 298 298 298 VAL VAL B . n 
B 1 299 ALA 299 299 299 ALA ALA B . n 
B 1 300 THR 300 300 300 THR THR B . n 
B 1 301 SER 301 301 301 SER SER B . n 
B 1 302 SER 302 302 302 SER SER B . n 
B 1 303 PRO 303 303 303 PRO PRO B . n 
B 1 304 ASP 304 304 304 ASP ASP B . n 
B 1 305 LEU 305 305 305 LEU LEU B . n 
B 1 306 PRO 306 306 306 PRO PRO B . n 
B 1 307 ASP 307 307 307 ASP ASP B . n 
B 1 308 LEU 308 308 308 LEU LEU B . n 
B 1 309 SER 309 309 309 SER SER B . n 
B 1 310 ALA 310 310 310 ALA ALA B . n 
B 1 311 LEU 311 311 311 LEU LEU B . n 
B 1 312 VAL 312 312 312 VAL VAL B . n 
B 1 313 ALA 313 313 313 ALA ALA B . n 
B 1 314 ASP 314 314 314 ASP ASP B . n 
B 1 315 TYR 315 315 315 TYR TYR B . n 
B 1 316 THR 316 316 316 THR THR B . n 
B 1 317 ARG 317 317 317 ARG ARG B . n 
B 1 318 MET 318 318 318 MET MET B . n 
B 1 319 LEU 319 319 319 LEU LEU B . n 
B 1 320 LEU 320 320 320 LEU LEU B . n 
B 1 321 VAL 321 321 321 VAL VAL B . n 
B 1 322 VAL 322 322 322 VAL VAL B . n 
B 1 323 LEU 323 323 323 LEU LEU B . n 
B 1 324 ALA 324 324 324 ALA ALA B . n 
B 1 325 ARG 325 325 325 ARG ARG B . n 
B 1 326 GLY 326 326 326 GLY GLY B . n 
B 1 327 LEU 327 327 327 LEU LEU B . n 
B 1 328 ALA 328 328 328 ALA ALA B . n 
B 1 329 PRO 329 329 329 PRO PRO B . n 
B 1 330 GLU 330 330 330 GLU GLU B . n 
B 1 331 GLY 331 331 331 GLY GLY B . n 
B 1 332 THR 332 332 332 THR THR B . n 
B 1 333 GLU 333 333 333 GLU GLU B . n 
B 1 334 PRO 334 334 334 PRO PRO B . n 
B 1 335 VAL 335 335 335 VAL VAL B . n 
B 1 336 SER 336 336 336 SER SER B . n 
B 1 337 LEU 337 337 337 LEU LEU B . n 
B 1 338 ASN 338 338 338 ASN ASN B . n 
B 1 339 ALA 339 339 339 ALA ALA B . n 
B 1 340 TRP 340 340 340 TRP TRP B . n 
B 1 341 TYR 341 341 341 TYR TYR B . n 
B 1 342 ALA 342 342 342 ALA ALA B . n 
B 1 343 MET 343 343 343 MET MET B . n 
B 1 344 LEU 344 344 344 LEU LEU B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 ASP 346 346 346 ASP ASP B . n 
B 1 347 GLN 347 347 347 GLN GLN B . n 
B 1 348 ALA 348 348 348 ALA ALA B . n 
B 1 349 ARG 349 349 349 ARG ARG B . n 
B 1 350 MET 350 350 350 MET MET B . n 
B 1 351 MET 351 351 351 MET MET B . n 
B 1 352 ARG 352 352 352 ARG ARG B . n 
B 1 353 ALA 353 353 353 ALA ALA B . n 
B 1 354 PHE 354 354 354 PHE PHE B . n 
B 1 355 ASP 355 355 355 ASP ASP B . n 
B 1 356 ARG 356 356 356 ARG ARG B . n 
B 1 357 LEU 357 357 357 LEU LEU B . n 
B 1 358 PHE 358 358 358 PHE PHE B . n 
B 1 359 GLU 359 359 359 GLU GLU B . n 
B 1 360 SER 360 360 360 SER SER B . n 
B 1 361 PHE 361 361 361 PHE PHE B . n 
B 1 362 ASP 362 362 362 ASP ASP B . n 
B 1 363 ALA 363 363 363 ALA ALA B . n 
B 1 364 ILE 364 364 364 ILE ILE B . n 
B 1 365 PHE 365 365 365 PHE PHE B . n 
B 1 366 CYS 366 366 366 CYS CYS B . n 
B 1 367 PRO 367 367 367 PRO PRO B . n 
B 1 368 VAL 368 368 368 VAL VAL B . n 
B 1 369 LEU 369 369 369 LEU LEU B . n 
B 1 370 GLY 370 370 370 GLY GLY B . n 
B 1 371 THR 371 371 371 THR THR B . n 
B 1 372 THR 372 372 372 THR THR B . n 
B 1 373 ALA 373 373 373 ALA ALA B . n 
B 1 374 PHE 374 374 374 PHE PHE B . n 
B 1 375 ALA 375 375 375 ALA ALA B . n 
B 1 376 HIS 376 376 376 HIS HIS B . n 
B 1 377 SER 377 377 377 SER SER B . n 
B 1 378 ASP 378 378 378 ASP ASP B . n 
B 1 379 GLU 379 379 379 GLU GLU B . n 
B 1 380 PRO 380 380 380 PRO PRO B . n 
B 1 381 ASP 381 381 381 ASP ASP B . n 
B 1 382 TRP 382 382 382 TRP TRP B . n 
B 1 383 ALA 383 383 383 ALA ALA B . n 
B 1 384 LYS 384 384 384 LYS LYS B . n 
B 1 385 ARG 385 385 385 ARG ARG B . n 
B 1 386 SER 386 386 386 SER SER B . n 
B 1 387 LEU 387 387 387 LEU LEU B . n 
B 1 388 SER 388 388 388 SER SER B . n 
B 1 389 ILE 389 389 389 ILE ILE B . n 
B 1 390 ASP 390 390 390 ASP ASP B . n 
B 1 391 GLY 391 391 391 GLY GLY B . n 
B 1 392 GLY 392 392 392 GLY GLY B . n 
B 1 393 ILE 393 393 393 ILE ILE B . n 
B 1 394 ALA 394 394 394 ALA ALA B . n 
B 1 395 PRO 395 395 395 PRO PRO B . n 
B 1 396 PHE 396 396 396 PHE PHE B . n 
B 1 397 ALA 397 397 397 ALA ALA B . n 
B 1 398 ALA 398 398 398 ALA ALA B . n 
B 1 399 GLN 399 399 399 GLN GLN B . n 
B 1 400 LEU 400 400 400 LEU LEU B . n 
B 1 401 GLY 401 401 401 GLY GLY B . n 
B 1 402 TRP 402 402 402 TRP TRP B . n 
B 1 403 ILE 403 403 403 ILE ILE B . n 
B 1 404 SER 404 404 404 SER SER B . n 
B 1 405 MET 405 405 405 MET MET B . n 
B 1 406 ALA 406 406 406 ALA ALA B . n 
B 1 407 THR 407 407 407 THR THR B . n 
B 1 408 TYR 408 408 408 TYR TYR B . n 
B 1 409 GLY 409 409 409 GLY GLY B . n 
B 1 410 GLY 410 410 410 GLY GLY B . n 
B 1 411 MET 411 411 411 MET MET B . n 
B 1 412 PRO 412 412 412 PRO PRO B . n 
B 1 413 ALA 413 413 413 ALA ALA B . n 
B 1 414 LEU 414 414 414 LEU LEU B . n 
B 1 415 SER 415 415 415 SER SER B . n 
B 1 416 MET 416 416 416 MET MET B . n 
B 1 417 PRO 417 417 417 PRO PRO B . n 
B 1 418 LEU 418 418 418 LEU LEU B . n 
B 1 419 GLY 419 419 419 GLY GLY B . n 
B 1 420 ALA 420 420 420 ALA ALA B . n 
B 1 421 ASP 421 421 421 ASP ASP B . n 
B 1 422 GLY 422 422 422 GLY GLY B . n 
B 1 423 ASN 423 423 423 ASN ASN B . n 
B 1 424 GLY 424 424 424 GLY GLY B . n 
B 1 425 LEU 425 425 425 LEU LEU B . n 
B 1 426 PRO 426 426 426 PRO PRO B . n 
B 1 427 ILE 427 427 427 ILE ILE B . n 
B 1 428 ASN 428 428 428 ASN ASN B . n 
B 1 429 LEU 429 429 429 LEU LEU B . n 
B 1 430 GLN 430 430 430 GLN GLN B . n 
B 1 431 ILE 431 431 431 ILE ILE B . n 
B 1 432 ILE 432 432 432 ILE ILE B . n 
B 1 433 THR 433 433 433 THR THR B . n 
B 1 434 ARG 434 434 434 ARG ARG B . n 
B 1 435 ASN 435 435 435 ASN ASN B . n 
B 1 436 TRP 436 436 436 TRP TRP B . n 
B 1 437 SER 437 437 437 SER SER B . n 
B 1 438 ASP 438 438 438 ASP ASP B . n 
B 1 439 HIS 439 439 439 HIS HIS B . n 
B 1 440 ASP 440 440 440 ASP ASP B . n 
B 1 441 ALA 441 441 441 ALA ALA B . n 
B 1 442 ILE 442 442 442 ILE ILE B . n 
B 1 443 ARG 443 443 443 ARG ARG B . n 
B 1 444 ILE 444 444 444 ILE ILE B . n 
B 1 445 GLY 445 445 445 GLY GLY B . n 
B 1 446 ALA 446 446 446 ALA ALA B . n 
B 1 447 LEU 447 447 447 LEU LEU B . n 
B 1 448 VAL 448 448 448 VAL VAL B . n 
B 1 449 ALA 449 449 449 ALA ALA B . n 
B 1 450 GLU 450 450 450 GLU GLU B . n 
B 1 451 ALA 451 451 451 ALA ALA B . n 
B 1 452 LEU 452 452 452 LEU LEU B . n 
B 1 453 ASP 453 453 453 ASP ASP B . n 
B 1 454 ARG 454 454 454 ARG ARG B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D5H 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D5H 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 A1D5H 1   501 502 A1D5H BBC A . 
D 3 GOL   1   502 503 GOL   GOL A . 
E 3 GOL   1   503 504 GOL   GOL A . 
F 2 A1D5H 1   504 501 A1D5H BBC A . 
G 2 A1D5H 1   501 501 A1D5H BBC B . 
H 4 HOH   1   601 261 HOH   HOH A . 
H 4 HOH   2   602 245 HOH   HOH A . 
H 4 HOH   3   603 297 HOH   HOH A . 
H 4 HOH   4   604 65  HOH   HOH A . 
H 4 HOH   5   605 73  HOH   HOH A . 
H 4 HOH   6   606 24  HOH   HOH A . 
H 4 HOH   7   607 304 HOH   HOH A . 
H 4 HOH   8   608 99  HOH   HOH A . 
H 4 HOH   9   609 70  HOH   HOH A . 
H 4 HOH   10  610 100 HOH   HOH A . 
H 4 HOH   11  611 6   HOH   HOH A . 
H 4 HOH   12  612 40  HOH   HOH A . 
H 4 HOH   13  613 185 HOH   HOH A . 
H 4 HOH   14  614 191 HOH   HOH A . 
H 4 HOH   15  615 89  HOH   HOH A . 
H 4 HOH   16  616 113 HOH   HOH A . 
H 4 HOH   17  617 47  HOH   HOH A . 
H 4 HOH   18  618 165 HOH   HOH A . 
H 4 HOH   19  619 270 HOH   HOH A . 
H 4 HOH   20  620 23  HOH   HOH A . 
H 4 HOH   21  621 232 HOH   HOH A . 
H 4 HOH   22  622 51  HOH   HOH A . 
H 4 HOH   23  623 172 HOH   HOH A . 
H 4 HOH   24  624 379 HOH   HOH A . 
H 4 HOH   25  625 101 HOH   HOH A . 
H 4 HOH   26  626 257 HOH   HOH A . 
H 4 HOH   27  627 213 HOH   HOH A . 
H 4 HOH   28  628 1   HOH   HOH A . 
H 4 HOH   29  629 94  HOH   HOH A . 
H 4 HOH   30  630 326 HOH   HOH A . 
H 4 HOH   31  631 152 HOH   HOH A . 
H 4 HOH   32  632 55  HOH   HOH A . 
H 4 HOH   33  633 18  HOH   HOH A . 
H 4 HOH   34  634 91  HOH   HOH A . 
H 4 HOH   35  635 179 HOH   HOH A . 
H 4 HOH   36  636 109 HOH   HOH A . 
H 4 HOH   37  637 170 HOH   HOH A . 
H 4 HOH   38  638 45  HOH   HOH A . 
H 4 HOH   39  639 250 HOH   HOH A . 
H 4 HOH   40  640 315 HOH   HOH A . 
H 4 HOH   41  641 370 HOH   HOH A . 
H 4 HOH   42  642 130 HOH   HOH A . 
H 4 HOH   43  643 102 HOH   HOH A . 
H 4 HOH   44  644 8   HOH   HOH A . 
H 4 HOH   45  645 181 HOH   HOH A . 
H 4 HOH   46  646 342 HOH   HOH A . 
H 4 HOH   47  647 39  HOH   HOH A . 
H 4 HOH   48  648 162 HOH   HOH A . 
H 4 HOH   49  649 110 HOH   HOH A . 
H 4 HOH   50  650 325 HOH   HOH A . 
H 4 HOH   51  651 34  HOH   HOH A . 
H 4 HOH   52  652 160 HOH   HOH A . 
H 4 HOH   53  653 12  HOH   HOH A . 
H 4 HOH   54  654 343 HOH   HOH A . 
H 4 HOH   55  655 348 HOH   HOH A . 
H 4 HOH   56  656 331 HOH   HOH A . 
H 4 HOH   57  657 15  HOH   HOH A . 
H 4 HOH   58  658 280 HOH   HOH A . 
H 4 HOH   59  659 52  HOH   HOH A . 
H 4 HOH   60  660 87  HOH   HOH A . 
H 4 HOH   61  661 243 HOH   HOH A . 
H 4 HOH   62  662 25  HOH   HOH A . 
H 4 HOH   63  663 161 HOH   HOH A . 
H 4 HOH   64  664 71  HOH   HOH A . 
H 4 HOH   65  665 60  HOH   HOH A . 
H 4 HOH   66  666 376 HOH   HOH A . 
H 4 HOH   67  667 56  HOH   HOH A . 
H 4 HOH   68  668 382 HOH   HOH A . 
H 4 HOH   69  669 268 HOH   HOH A . 
H 4 HOH   70  670 146 HOH   HOH A . 
H 4 HOH   71  671 93  HOH   HOH A . 
H 4 HOH   72  672 105 HOH   HOH A . 
H 4 HOH   73  673 134 HOH   HOH A . 
H 4 HOH   74  674 171 HOH   HOH A . 
H 4 HOH   75  675 106 HOH   HOH A . 
H 4 HOH   76  676 380 HOH   HOH A . 
H 4 HOH   77  677 371 HOH   HOH A . 
H 4 HOH   78  678 41  HOH   HOH A . 
H 4 HOH   79  679 328 HOH   HOH A . 
H 4 HOH   80  680 247 HOH   HOH A . 
H 4 HOH   81  681 324 HOH   HOH A . 
H 4 HOH   82  682 166 HOH   HOH A . 
H 4 HOH   83  683 307 HOH   HOH A . 
H 4 HOH   84  684 67  HOH   HOH A . 
H 4 HOH   85  685 377 HOH   HOH A . 
H 4 HOH   86  686 20  HOH   HOH A . 
H 4 HOH   87  687 229 HOH   HOH A . 
H 4 HOH   88  688 224 HOH   HOH A . 
H 4 HOH   89  689 334 HOH   HOH A . 
H 4 HOH   90  690 234 HOH   HOH A . 
H 4 HOH   91  691 367 HOH   HOH A . 
H 4 HOH   92  692 238 HOH   HOH A . 
H 4 HOH   93  693 13  HOH   HOH A . 
H 4 HOH   94  694 194 HOH   HOH A . 
H 4 HOH   95  695 76  HOH   HOH A . 
H 4 HOH   96  696 378 HOH   HOH A . 
H 4 HOH   97  697 151 HOH   HOH A . 
H 4 HOH   98  698 38  HOH   HOH A . 
H 4 HOH   99  699 372 HOH   HOH A . 
H 4 HOH   100 700 158 HOH   HOH A . 
H 4 HOH   101 701 294 HOH   HOH A . 
H 4 HOH   102 702 311 HOH   HOH A . 
H 4 HOH   103 703 54  HOH   HOH A . 
H 4 HOH   104 704 36  HOH   HOH A . 
H 4 HOH   105 705 249 HOH   HOH A . 
H 4 HOH   106 706 4   HOH   HOH A . 
H 4 HOH   107 707 264 HOH   HOH A . 
H 4 HOH   108 708 22  HOH   HOH A . 
H 4 HOH   109 709 16  HOH   HOH A . 
H 4 HOH   110 710 262 HOH   HOH A . 
H 4 HOH   111 711 137 HOH   HOH A . 
H 4 HOH   112 712 360 HOH   HOH A . 
H 4 HOH   113 713 157 HOH   HOH A . 
H 4 HOH   114 714 241 HOH   HOH A . 
H 4 HOH   115 715 290 HOH   HOH A . 
H 4 HOH   116 716 344 HOH   HOH A . 
H 4 HOH   117 717 44  HOH   HOH A . 
H 4 HOH   118 718 233 HOH   HOH A . 
H 4 HOH   119 719 182 HOH   HOH A . 
H 4 HOH   120 720 58  HOH   HOH A . 
H 4 HOH   121 721 337 HOH   HOH A . 
H 4 HOH   122 722 122 HOH   HOH A . 
H 4 HOH   123 723 98  HOH   HOH A . 
H 4 HOH   124 724 69  HOH   HOH A . 
H 4 HOH   125 725 327 HOH   HOH A . 
H 4 HOH   126 726 310 HOH   HOH A . 
H 4 HOH   127 727 216 HOH   HOH A . 
H 4 HOH   128 728 228 HOH   HOH A . 
H 4 HOH   129 729 176 HOH   HOH A . 
H 4 HOH   130 730 291 HOH   HOH A . 
H 4 HOH   131 731 338 HOH   HOH A . 
H 4 HOH   132 732 96  HOH   HOH A . 
H 4 HOH   133 733 289 HOH   HOH A . 
H 4 HOH   134 734 128 HOH   HOH A . 
H 4 HOH   135 735 330 HOH   HOH A . 
H 4 HOH   136 736 359 HOH   HOH A . 
H 4 HOH   137 737 269 HOH   HOH A . 
H 4 HOH   138 738 354 HOH   HOH A . 
H 4 HOH   139 739 258 HOH   HOH A . 
H 4 HOH   140 740 205 HOH   HOH A . 
H 4 HOH   141 741 190 HOH   HOH A . 
H 4 HOH   142 742 352 HOH   HOH A . 
H 4 HOH   143 743 222 HOH   HOH A . 
H 4 HOH   144 744 316 HOH   HOH A . 
H 4 HOH   145 745 301 HOH   HOH A . 
H 4 HOH   146 746 358 HOH   HOH A . 
H 4 HOH   147 747 78  HOH   HOH A . 
H 4 HOH   148 748 186 HOH   HOH A . 
H 4 HOH   149 749 178 HOH   HOH A . 
H 4 HOH   150 750 329 HOH   HOH A . 
H 4 HOH   151 751 208 HOH   HOH A . 
H 4 HOH   152 752 332 HOH   HOH A . 
H 4 HOH   153 753 292 HOH   HOH A . 
H 4 HOH   154 754 351 HOH   HOH A . 
H 4 HOH   155 755 363 HOH   HOH A . 
H 4 HOH   156 756 357 HOH   HOH A . 
H 4 HOH   157 757 333 HOH   HOH A . 
H 4 HOH   158 758 225 HOH   HOH A . 
H 4 HOH   159 759 362 HOH   HOH A . 
H 4 HOH   160 760 365 HOH   HOH A . 
H 4 HOH   161 761 140 HOH   HOH A . 
H 4 HOH   162 762 308 HOH   HOH A . 
H 4 HOH   163 763 127 HOH   HOH A . 
H 4 HOH   164 764 368 HOH   HOH A . 
H 4 HOH   165 765 124 HOH   HOH A . 
H 4 HOH   166 766 384 HOH   HOH A . 
H 4 HOH   167 767 132 HOH   HOH A . 
H 4 HOH   168 768 244 HOH   HOH A . 
H 4 HOH   169 769 281 HOH   HOH A . 
H 4 HOH   170 770 49  HOH   HOH A . 
H 4 HOH   171 771 150 HOH   HOH A . 
H 4 HOH   172 772 383 HOH   HOH A . 
H 4 HOH   173 773 199 HOH   HOH A . 
H 4 HOH   174 774 309 HOH   HOH A . 
H 4 HOH   175 775 230 HOH   HOH A . 
H 4 HOH   176 776 206 HOH   HOH A . 
H 4 HOH   177 777 256 HOH   HOH A . 
H 4 HOH   178 778 284 HOH   HOH A . 
H 4 HOH   179 779 366 HOH   HOH A . 
H 4 HOH   180 780 155 HOH   HOH A . 
H 4 HOH   181 781 149 HOH   HOH A . 
I 4 HOH   1   601 33  HOH   HOH B . 
I 4 HOH   2   602 318 HOH   HOH B . 
I 4 HOH   3   603 272 HOH   HOH B . 
I 4 HOH   4   604 92  HOH   HOH B . 
I 4 HOH   5   605 196 HOH   HOH B . 
I 4 HOH   6   606 27  HOH   HOH B . 
I 4 HOH   7   607 142 HOH   HOH B . 
I 4 HOH   8   608 120 HOH   HOH B . 
I 4 HOH   9   609 9   HOH   HOH B . 
I 4 HOH   10  610 210 HOH   HOH B . 
I 4 HOH   11  611 240 HOH   HOH B . 
I 4 HOH   12  612 68  HOH   HOH B . 
I 4 HOH   13  613 235 HOH   HOH B . 
I 4 HOH   14  614 203 HOH   HOH B . 
I 4 HOH   15  615 83  HOH   HOH B . 
I 4 HOH   16  616 323 HOH   HOH B . 
I 4 HOH   17  617 43  HOH   HOH B . 
I 4 HOH   18  618 195 HOH   HOH B . 
I 4 HOH   19  619 287 HOH   HOH B . 
I 4 HOH   20  620 314 HOH   HOH B . 
I 4 HOH   21  621 202 HOH   HOH B . 
I 4 HOH   22  622 53  HOH   HOH B . 
I 4 HOH   23  623 35  HOH   HOH B . 
I 4 HOH   24  624 136 HOH   HOH B . 
I 4 HOH   25  625 48  HOH   HOH B . 
I 4 HOH   26  626 61  HOH   HOH B . 
I 4 HOH   27  627 46  HOH   HOH B . 
I 4 HOH   28  628 135 HOH   HOH B . 
I 4 HOH   29  629 88  HOH   HOH B . 
I 4 HOH   30  630 183 HOH   HOH B . 
I 4 HOH   31  631 29  HOH   HOH B . 
I 4 HOH   32  632 42  HOH   HOH B . 
I 4 HOH   33  633 173 HOH   HOH B . 
I 4 HOH   34  634 30  HOH   HOH B . 
I 4 HOH   35  635 84  HOH   HOH B . 
I 4 HOH   36  636 219 HOH   HOH B . 
I 4 HOH   37  637 50  HOH   HOH B . 
I 4 HOH   38  638 252 HOH   HOH B . 
I 4 HOH   39  639 119 HOH   HOH B . 
I 4 HOH   40  640 374 HOH   HOH B . 
I 4 HOH   41  641 373 HOH   HOH B . 
I 4 HOH   42  642 189 HOH   HOH B . 
I 4 HOH   43  643 236 HOH   HOH B . 
I 4 HOH   44  644 114 HOH   HOH B . 
I 4 HOH   45  645 85  HOH   HOH B . 
I 4 HOH   46  646 126 HOH   HOH B . 
I 4 HOH   47  647 231 HOH   HOH B . 
I 4 HOH   48  648 10  HOH   HOH B . 
I 4 HOH   49  649 133 HOH   HOH B . 
I 4 HOH   50  650 66  HOH   HOH B . 
I 4 HOH   51  651 107 HOH   HOH B . 
I 4 HOH   52  652 2   HOH   HOH B . 
I 4 HOH   53  653 19  HOH   HOH B . 
I 4 HOH   54  654 3   HOH   HOH B . 
I 4 HOH   55  655 14  HOH   HOH B . 
I 4 HOH   56  656 283 HOH   HOH B . 
I 4 HOH   57  657 26  HOH   HOH B . 
I 4 HOH   58  658 112 HOH   HOH B . 
I 4 HOH   59  659 260 HOH   HOH B . 
I 4 HOH   60  660 72  HOH   HOH B . 
I 4 HOH   61  661 116 HOH   HOH B . 
I 4 HOH   62  662 198 HOH   HOH B . 
I 4 HOH   63  663 263 HOH   HOH B . 
I 4 HOH   64  664 168 HOH   HOH B . 
I 4 HOH   65  665 214 HOH   HOH B . 
I 4 HOH   66  666 163 HOH   HOH B . 
I 4 HOH   67  667 11  HOH   HOH B . 
I 4 HOH   68  668 154 HOH   HOH B . 
I 4 HOH   69  669 108 HOH   HOH B . 
I 4 HOH   70  670 75  HOH   HOH B . 
I 4 HOH   71  671 117 HOH   HOH B . 
I 4 HOH   72  672 5   HOH   HOH B . 
I 4 HOH   73  673 184 HOH   HOH B . 
I 4 HOH   74  674 104 HOH   HOH B . 
I 4 HOH   75  675 103 HOH   HOH B . 
I 4 HOH   76  676 143 HOH   HOH B . 
I 4 HOH   77  677 144 HOH   HOH B . 
I 4 HOH   78  678 57  HOH   HOH B . 
I 4 HOH   79  679 138 HOH   HOH B . 
I 4 HOH   80  680 62  HOH   HOH B . 
I 4 HOH   81  681 336 HOH   HOH B . 
I 4 HOH   82  682 174 HOH   HOH B . 
I 4 HOH   83  683 32  HOH   HOH B . 
I 4 HOH   84  684 187 HOH   HOH B . 
I 4 HOH   85  685 129 HOH   HOH B . 
I 4 HOH   86  686 64  HOH   HOH B . 
I 4 HOH   87  687 118 HOH   HOH B . 
I 4 HOH   88  688 111 HOH   HOH B . 
I 4 HOH   89  689 121 HOH   HOH B . 
I 4 HOH   90  690 139 HOH   HOH B . 
I 4 HOH   91  691 90  HOH   HOH B . 
I 4 HOH   92  692 97  HOH   HOH B . 
I 4 HOH   93  693 255 HOH   HOH B . 
I 4 HOH   94  694 63  HOH   HOH B . 
I 4 HOH   95  695 201 HOH   HOH B . 
I 4 HOH   96  696 28  HOH   HOH B . 
I 4 HOH   97  697 217 HOH   HOH B . 
I 4 HOH   98  698 141 HOH   HOH B . 
I 4 HOH   99  699 74  HOH   HOH B . 
I 4 HOH   100 700 7   HOH   HOH B . 
I 4 HOH   101 701 341 HOH   HOH B . 
I 4 HOH   102 702 86  HOH   HOH B . 
I 4 HOH   103 703 82  HOH   HOH B . 
I 4 HOH   104 704 169 HOH   HOH B . 
I 4 HOH   105 705 248 HOH   HOH B . 
I 4 HOH   106 706 180 HOH   HOH B . 
I 4 HOH   107 707 226 HOH   HOH B . 
I 4 HOH   108 708 223 HOH   HOH B . 
I 4 HOH   109 709 218 HOH   HOH B . 
I 4 HOH   110 710 79  HOH   HOH B . 
I 4 HOH   111 711 347 HOH   HOH B . 
I 4 HOH   112 712 237 HOH   HOH B . 
I 4 HOH   113 713 37  HOH   HOH B . 
I 4 HOH   114 714 175 HOH   HOH B . 
I 4 HOH   115 715 221 HOH   HOH B . 
I 4 HOH   116 716 288 HOH   HOH B . 
I 4 HOH   117 717 227 HOH   HOH B . 
I 4 HOH   118 718 271 HOH   HOH B . 
I 4 HOH   119 719 145 HOH   HOH B . 
I 4 HOH   120 720 286 HOH   HOH B . 
I 4 HOH   121 721 115 HOH   HOH B . 
I 4 HOH   122 722 340 HOH   HOH B . 
I 4 HOH   123 723 303 HOH   HOH B . 
I 4 HOH   124 724 123 HOH   HOH B . 
I 4 HOH   125 725 188 HOH   HOH B . 
I 4 HOH   126 726 167 HOH   HOH B . 
I 4 HOH   127 727 317 HOH   HOH B . 
I 4 HOH   128 728 266 HOH   HOH B . 
I 4 HOH   129 729 279 HOH   HOH B . 
I 4 HOH   130 730 153 HOH   HOH B . 
I 4 HOH   131 731 265 HOH   HOH B . 
I 4 HOH   132 732 299 HOH   HOH B . 
I 4 HOH   133 733 349 HOH   HOH B . 
I 4 HOH   134 734 239 HOH   HOH B . 
I 4 HOH   135 735 212 HOH   HOH B . 
I 4 HOH   136 736 346 HOH   HOH B . 
I 4 HOH   137 737 375 HOH   HOH B . 
I 4 HOH   138 738 302 HOH   HOH B . 
I 4 HOH   139 739 254 HOH   HOH B . 
I 4 HOH   140 740 200 HOH   HOH B . 
I 4 HOH   141 741 242 HOH   HOH B . 
I 4 HOH   142 742 207 HOH   HOH B . 
I 4 HOH   143 743 156 HOH   HOH B . 
I 4 HOH   144 744 381 HOH   HOH B . 
I 4 HOH   145 745 355 HOH   HOH B . 
I 4 HOH   146 746 77  HOH   HOH B . 
I 4 HOH   147 747 320 HOH   HOH B . 
I 4 HOH   148 748 305 HOH   HOH B . 
I 4 HOH   149 749 192 HOH   HOH B . 
I 4 HOH   150 750 353 HOH   HOH B . 
I 4 HOH   151 751 356 HOH   HOH B . 
I 4 HOH   152 752 59  HOH   HOH B . 
I 4 HOH   153 753 306 HOH   HOH B . 
I 4 HOH   154 754 312 HOH   HOH B . 
I 4 HOH   155 755 274 HOH   HOH B . 
I 4 HOH   156 756 345 HOH   HOH B . 
I 4 HOH   157 757 197 HOH   HOH B . 
I 4 HOH   158 758 81  HOH   HOH B . 
I 4 HOH   159 759 31  HOH   HOH B . 
I 4 HOH   160 760 319 HOH   HOH B . 
I 4 HOH   161 761 267 HOH   HOH B . 
I 4 HOH   162 762 253 HOH   HOH B . 
I 4 HOH   163 763 177 HOH   HOH B . 
I 4 HOH   164 764 148 HOH   HOH B . 
I 4 HOH   165 765 361 HOH   HOH B . 
I 4 HOH   166 766 313 HOH   HOH B . 
I 4 HOH   167 767 321 HOH   HOH B . 
I 4 HOH   168 768 322 HOH   HOH B . 
I 4 HOH   169 769 278 HOH   HOH B . 
I 4 HOH   170 770 364 HOH   HOH B . 
I 4 HOH   171 771 296 HOH   HOH B . 
I 4 HOH   172 772 335 HOH   HOH B . 
I 4 HOH   173 773 246 HOH   HOH B . 
I 4 HOH   174 774 209 HOH   HOH B . 
I 4 HOH   175 775 220 HOH   HOH B . 
I 4 HOH   176 776 125 HOH   HOH B . 
I 4 HOH   177 777 369 HOH   HOH B . 
I 4 HOH   178 778 147 HOH   HOH B . 
I 4 HOH   179 779 95  HOH   HOH B . 
I 4 HOH   180 780 298 HOH   HOH B . 
I 4 HOH   181 781 251 HOH   HOH B . 
I 4 HOH   182 782 17  HOH   HOH B . 
I 4 HOH   183 783 21  HOH   HOH B . 
I 4 HOH   184 784 350 HOH   HOH B . 
I 4 HOH   185 785 211 HOH   HOH B . 
I 4 HOH   186 786 300 HOH   HOH B . 
I 4 HOH   187 787 204 HOH   HOH B . 
I 4 HOH   188 788 285 HOH   HOH B . 
I 4 HOH   189 789 339 HOH   HOH B . 
I 4 HOH   190 790 259 HOH   HOH B . 
I 4 HOH   191 791 273 HOH   HOH B . 
I 4 HOH   192 792 215 HOH   HOH B . 
I 4 HOH   193 793 80  HOH   HOH B . 
I 4 HOH   194 794 277 HOH   HOH B . 
I 4 HOH   195 795 193 HOH   HOH B . 
I 4 HOH   196 796 159 HOH   HOH B . 
I 4 HOH   197 797 131 HOH   HOH B . 
I 4 HOH   198 798 293 HOH   HOH B . 
I 4 HOH   199 799 164 HOH   HOH B . 
I 4 HOH   200 800 276 HOH   HOH B . 
I 4 HOH   201 801 275 HOH   HOH B . 
I 4 HOH   202 802 282 HOH   HOH B . 
I 4 HOH   203 803 295 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.21_5207: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                  2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                  3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                  4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XTC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     86.800 
_cell.length_a_esd                 ? 
_cell.length_b                     86.800 
_cell.length_b_esd                 ? 
_cell.length_c                     276.730 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        16 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XTC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XTC 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.85 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.91 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Mgcl2, 0.1M Tris pH8.5, 30% PEG4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8XTC 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.4 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     42385 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                25.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.69 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.46 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3050 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               25.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.59 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XTC 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             19.27 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42279 
_refine.ls_number_reflns_R_free                  2115 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.78 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2086 
_refine.ls_R_factor_R_free                       0.2540 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2062 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.56 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.32 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.40 
_refine_hist.d_res_low                        19.27 
_refine_hist.number_atoms_solvent             384 
_refine_hist.number_atoms_total               6853 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6441 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         28 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.002  ? 6599 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.513  ? 8990 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 12.162 ? 2323 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.041  ? 1035 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.004  ? 1181 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.40 2.46  . . 137 2604 99.00  . . . . 0.2927 . . . . . . . . . . . 0.3210 
'X-RAY DIFFRACTION' 2.46 2.52  . . 138 2617 100.00 . . . . 0.2763 . . . . . . . . . . . 0.2924 
'X-RAY DIFFRACTION' 2.52 2.58  . . 139 2640 100.00 . . . . 0.2709 . . . . . . . . . . . 0.2980 
'X-RAY DIFFRACTION' 2.59 2.66  . . 139 2640 100.00 . . . . 0.2705 . . . . . . . . . . . 0.3339 
'X-RAY DIFFRACTION' 2.66 2.75  . . 138 2624 100.00 . . . . 0.2518 . . . . . . . . . . . 0.2940 
'X-RAY DIFFRACTION' 2.75 2.84  . . 139 2644 100.00 . . . . 0.2561 . . . . . . . . . . . 0.3056 
'X-RAY DIFFRACTION' 2.84 2.96  . . 139 2638 100.00 . . . . 0.2472 . . . . . . . . . . . 0.3149 
'X-RAY DIFFRACTION' 2.96 3.09  . . 140 2666 100.00 . . . . 0.2446 . . . . . . . . . . . 0.2788 
'X-RAY DIFFRACTION' 3.09 3.25  . . 140 2660 100.00 . . . . 0.2291 . . . . . . . . . . . 0.2628 
'X-RAY DIFFRACTION' 3.25 3.46  . . 141 2672 100.00 . . . . 0.2119 . . . . . . . . . . . 0.2801 
'X-RAY DIFFRACTION' 3.46 3.72  . . 141 2667 100.00 . . . . 0.1939 . . . . . . . . . . . 0.2282 
'X-RAY DIFFRACTION' 3.72 4.09  . . 142 2697 100.00 . . . . 0.1747 . . . . . . . . . . . 0.2388 
'X-RAY DIFFRACTION' 4.09 4.68  . . 142 2717 100.00 . . . . 0.1588 . . . . . . . . . . . 0.2094 
'X-RAY DIFFRACTION' 4.68 5.87  . . 146 2764 100.00 . . . . 0.1805 . . . . . . . . . . . 0.2206 
'X-RAY DIFFRACTION' 5.87 19.27 . . 154 2914 100.00 . . . . 0.1857 . . . . . . . . . . . 0.2360 
# 
_struct.entry_id                     8XTC 
_struct.title                        
'Crystal structure of a novel PU plastic degradation urethanase UMG-SP2 mutant from uncultured bacterium in complex with ligand' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XTC 
_struct_keywords.text            'PU, degradation, mutant, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 2 ? 
G N N 2 ? 
H N N 4 ? 
I N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8XTC 
_struct_ref.pdbx_db_accession          8XTC 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XTC A 1 ? 454 ? 8XTC 1 ? 454 ? 1 454 
2 1 8XTC B 1 ? 454 ? 8XTC 1 ? 454 ? 1 454 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3000  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  30580 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 20  ? GLY A 31  ? SER A 20  GLY A 31  1 ? 12 
HELX_P HELX_P2  AA2 THR A 34  ? ASP A 50  ? THR A 34  ASP A 50  1 ? 17 
HELX_P HELX_P3  AA3 ASP A 60  ? ALA A 77  ? ASP A 60  ALA A 77  1 ? 18 
HELX_P HELX_P4  AA4 PHE A 105 ? ALA A 109 ? PHE A 105 ALA A 109 5 ? 5  
HELX_P HELX_P5  AA5 SER A 117 ? ALA A 126 ? SER A 117 ALA A 126 1 ? 10 
HELX_P HELX_P6  AA6 PRO A 137 ? ALA A 141 ? PRO A 137 ALA A 141 5 ? 5  
HELX_P HELX_P7  AA7 SER A 167 ? ALA A 176 ? SER A 167 ALA A 176 1 ? 10 
HELX_P HELX_P8  AA8 ILE A 191 ? GLY A 199 ? ILE A 191 GLY A 199 1 ? 9  
HELX_P HELX_P9  AA9 THR A 236 ? SER A 248 ? THR A 236 SER A 248 1 ? 13 
HELX_P HELX_P10 AB1 ASP A 277 ? ALA A 293 ? ASP A 277 ALA A 293 1 ? 17 
HELX_P HELX_P11 AB2 ASP A 307 ? ALA A 324 ? ASP A 307 ALA A 324 1 ? 18 
HELX_P HELX_P12 AB3 SER A 336 ? PHE A 358 ? SER A 336 PHE A 358 1 ? 23 
HELX_P HELX_P13 AB4 ASP A 381 ? LYS A 384 ? ASP A 381 LYS A 384 5 ? 4  
HELX_P HELX_P14 AB5 ALA A 397 ? GLN A 399 ? ALA A 397 GLN A 399 5 ? 3  
HELX_P HELX_P15 AB6 LEU A 400 ? GLY A 410 ? LEU A 400 GLY A 410 1 ? 11 
HELX_P HELX_P16 AB7 SER A 437 ? ARG A 454 ? SER A 437 ARG A 454 1 ? 18 
HELX_P HELX_P17 AB8 SER B 20  ? GLY B 30  ? SER B 20  GLY B 30  1 ? 11 
HELX_P HELX_P18 AB9 THR B 34  ? ASP B 50  ? THR B 34  ASP B 50  1 ? 17 
HELX_P HELX_P19 AC1 ASP B 60  ? ALA B 77  ? ASP B 60  ALA B 77  1 ? 18 
HELX_P HELX_P20 AC2 SER B 117 ? ALA B 126 ? SER B 117 ALA B 126 1 ? 10 
HELX_P HELX_P21 AC3 PRO B 137 ? ALA B 141 ? PRO B 137 ALA B 141 5 ? 5  
HELX_P HELX_P22 AC4 SER B 167 ? ALA B 176 ? SER B 167 ALA B 176 1 ? 10 
HELX_P HELX_P23 AC5 ILE B 191 ? GLY B 199 ? ILE B 191 GLY B 199 1 ? 9  
HELX_P HELX_P24 AC6 THR B 236 ? SER B 248 ? THR B 236 SER B 248 1 ? 13 
HELX_P HELX_P25 AC7 ASP B 277 ? SER B 294 ? ASP B 277 SER B 294 1 ? 18 
HELX_P HELX_P26 AC8 ASP B 307 ? ALA B 324 ? ASP B 307 ALA B 324 1 ? 18 
HELX_P HELX_P27 AC9 SER B 336 ? PHE B 358 ? SER B 336 PHE B 358 1 ? 23 
HELX_P HELX_P28 AD1 ASP B 381 ? LYS B 384 ? ASP B 381 LYS B 384 5 ? 4  
HELX_P HELX_P29 AD2 ALA B 397 ? GLN B 399 ? ALA B 397 GLN B 399 5 ? 3  
HELX_P HELX_P30 AD3 LEU B 400 ? GLY B 410 ? LEU B 400 GLY B 410 1 ? 11 
HELX_P HELX_P31 AD4 SER B 437 ? LEU B 452 ? SER B 437 LEU B 452 1 ? 16 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 8 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
AA7 ? 2 ? 
AA8 ? 2 ? 
AA9 ? 8 ? 
AB1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? parallel      
AA4 7 8 ? parallel      
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? parallel      
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AA9 4 5 ? anti-parallel 
AA9 5 6 ? anti-parallel 
AA9 6 7 ? parallel      
AA9 7 8 ? parallel      
AB1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 56  ? ARG A 59  ? VAL A 56  ARG A 59  
AA1 2 VAL A 129 ? SER A 134 ? VAL A 129 SER A 134 
AA1 3 PRO A 87  ? LYS A 91  ? PRO A 87  LYS A 91  
AA2 1 VAL A 146 ? ASN A 147 ? VAL A 146 ASN A 147 
AA2 2 GLY A 151 ? ARG A 152 ? GLY A 151 ARG A 152 
AA3 1 ASN A 154 ? ASN A 155 ? ASN A 154 ASN A 155 
AA3 2 ASP A 158 ? SER A 162 ? ASP A 158 SER A 162 
AA4 1 LEU A 181 ? ASP A 186 ? LEU A 181 ASP A 186 
AA4 2 VAL A 229 ? ALA A 234 ? VAL A 229 ALA A 234 
AA4 3 TRP A 201 ? LYS A 204 ? TRP A 201 LYS A 204 
AA4 4 ALA A 413 ? ALA A 420 ? ALA A 413 ALA A 420 
AA4 5 PRO A 426 ? ILE A 432 ? PRO A 426 ILE A 432 
AA4 6 ALA A 363 ? PRO A 367 ? ALA A 363 PRO A 367 
AA4 7 ARG A 264 ? LEU A 267 ? ARG A 264 LEU A 267 
AA4 8 THR A 297 ? ALA A 299 ? THR A 297 ALA A 299 
AA5 1 SER A 386 ? ILE A 389 ? SER A 386 ILE A 389 
AA5 2 GLY A 392 ? PRO A 395 ? GLY A 392 PRO A 395 
AA6 1 VAL B 56  ? ARG B 59  ? VAL B 56  ARG B 59  
AA6 2 VAL B 129 ? SER B 134 ? VAL B 129 SER B 134 
AA6 3 PRO B 87  ? LYS B 91  ? PRO B 87  LYS B 91  
AA7 1 VAL B 146 ? ASN B 147 ? VAL B 146 ASN B 147 
AA7 2 GLY B 151 ? ARG B 152 ? GLY B 151 ARG B 152 
AA8 1 ASN B 154 ? ASN B 155 ? ASN B 154 ASN B 155 
AA8 2 ASP B 158 ? SER B 162 ? ASP B 158 SER B 162 
AA9 1 LEU B 181 ? ASP B 186 ? LEU B 181 ASP B 186 
AA9 2 VAL B 229 ? ALA B 234 ? VAL B 229 ALA B 234 
AA9 3 TRP B 201 ? LYS B 204 ? TRP B 201 LYS B 204 
AA9 4 ALA B 413 ? ALA B 420 ? ALA B 413 ALA B 420 
AA9 5 PRO B 426 ? ILE B 432 ? PRO B 426 ILE B 432 
AA9 6 ALA B 363 ? PRO B 367 ? ALA B 363 PRO B 367 
AA9 7 ARG B 264 ? LEU B 267 ? ARG B 264 LEU B 267 
AA9 8 THR B 297 ? ALA B 299 ? THR B 297 ALA B 299 
AB1 1 SER B 386 ? ILE B 389 ? SER B 386 ILE B 389 
AB1 2 GLY B 392 ? PRO B 395 ? GLY B 392 PRO B 395 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 58  ? N VAL A 58  O LYS A 133 ? O LYS A 133 
AA1 2 3 O LEU A 131 ? O LEU A 131 N MET A 88  ? N MET A 88  
AA2 1 2 N ASN A 147 ? N ASN A 147 O GLY A 151 ? O GLY A 151 
AA3 1 2 N ASN A 155 ? N ASN A 155 O ARG A 161 ? O ARG A 161 
AA4 1 2 N ASP A 186 ? N ASP A 186 O VAL A 229 ? O VAL A 229 
AA4 2 3 O ALA A 234 ? O ALA A 234 N TRP A 201 ? N TRP A 201 
AA4 3 4 N GLY A 202 ? N GLY A 202 O SER A 415 ? O SER A 415 
AA4 4 5 N GLY A 419 ? N GLY A 419 O ILE A 427 ? O ILE A 427 
AA4 5 6 O ILE A 432 ? O ILE A 432 N ILE A 364 ? N ILE A 364 
AA4 6 7 O PHE A 365 ? O PHE A 365 N LEU A 266 ? N LEU A 266 
AA4 7 8 N ILE A 265 ? N ILE A 265 O ALA A 299 ? O ALA A 299 
AA5 1 2 N ILE A 389 ? N ILE A 389 O GLY A 392 ? O GLY A 392 
AA6 1 2 N VAL B 58  ? N VAL B 58  O LYS B 133 ? O LYS B 133 
AA6 2 3 O LEU B 131 ? O LEU B 131 N MET B 88  ? N MET B 88  
AA7 1 2 N ASN B 147 ? N ASN B 147 O GLY B 151 ? O GLY B 151 
AA8 1 2 N ASN B 155 ? N ASN B 155 O ARG B 161 ? O ARG B 161 
AA9 1 2 N GLU B 182 ? N GLU B 182 O MET B 233 ? O MET B 233 
AA9 2 3 O ALA B 234 ? O ALA B 234 N TRP B 201 ? N TRP B 201 
AA9 3 4 N LYS B 204 ? N LYS B 204 O ALA B 413 ? O ALA B 413 
AA9 4 5 N LEU B 414 ? N LEU B 414 O ILE B 431 ? O ILE B 431 
AA9 5 6 O GLN B 430 ? O GLN B 430 N CYS B 366 ? N CYS B 366 
AA9 6 7 O PHE B 365 ? O PHE B 365 N LEU B 266 ? N LEU B 266 
AA9 7 8 N LEU B 267 ? N LEU B 267 O ALA B 299 ? O ALA B 299 
AB1 1 2 N LEU B 387 ? N LEU B 387 O ALA B 394 ? O ALA B 394 
# 
_pdbx_entry_details.entry_id                   8XTC 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 77  ? ? -79.94  21.48   
2  1 ALA A 141 ? ? -110.93 55.04   
3  1 ASP A 158 ? ? -166.30 104.08  
4  1 SER A 166 ? ? 97.09   -17.94  
5  1 HIS A 215 ? ? -81.23  49.21   
6  1 LEU A 227 ? ? 71.05   -35.95  
7  1 SER A 437 ? ? -98.70  42.64   
8  1 TRP B 143 ? ? -87.44  32.23   
9  1 ASP B 158 ? ? -163.33 109.76  
10 1 SER B 166 ? ? 64.65   -65.51  
11 1 SER B 167 ? ? -96.51  39.84   
12 1 ASP B 186 ? ? -161.64 111.53  
13 1 LEU B 227 ? ? 77.51   -39.59  
14 1 ASP B 421 ? ? -94.27  -158.26 
15 1 SER B 437 ? ? -103.94 44.50   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     737 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   I 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 781 ? 7.03 . 
2 1 O ? B HOH 801 ? 6.47 . 
3 1 O ? B HOH 802 ? 7.54 . 
4 1 O ? B HOH 803 ? 8.45 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ASN 1  ? A ASN 1  
2  1 Y 1 A LEU 2  ? A LEU 2  
3  1 Y 1 A TYR 3  ? A TYR 3  
4  1 Y 1 A PHE 4  ? A PHE 4  
5  1 Y 1 A GLN 5  ? A GLN 5  
6  1 Y 1 A GLY 6  ? A GLY 6  
7  1 Y 1 A ALA 7  ? A ALA 7  
8  1 Y 1 A GLY 8  ? A GLY 8  
9  1 Y 1 A ALA 9  ? A ALA 9  
10 1 Y 1 A GLY 10 ? A GLY 10 
11 1 Y 1 A ALA 11 ? A ALA 11 
12 1 Y 1 A GLY 12 ? A GLY 12 
13 1 Y 1 A ALA 13 ? A ALA 13 
14 1 Y 1 A GLY 14 ? A GLY 14 
15 1 Y 1 B ASN 1  ? B ASN 1  
16 1 Y 1 B LEU 2  ? B LEU 2  
17 1 Y 1 B TYR 3  ? B TYR 3  
18 1 Y 1 B PHE 4  ? B PHE 4  
19 1 Y 1 B GLN 5  ? B GLN 5  
20 1 Y 1 B GLY 6  ? B GLY 6  
21 1 Y 1 B ALA 7  ? B ALA 7  
22 1 Y 1 B GLY 8  ? B GLY 8  
23 1 Y 1 B ALA 9  ? B ALA 9  
24 1 Y 1 B GLY 10 ? B GLY 10 
25 1 Y 1 B ALA 11 ? B ALA 11 
26 1 Y 1 B GLY 12 ? B GLY 12 
27 1 Y 1 B ALA 13 ? B ALA 13 
28 1 Y 1 B GLY 14 ? B GLY 14 
29 1 Y 1 B ALA 15 ? B ALA 15 
30 1 Y 1 B MET 16 ? B MET 16 
31 1 Y 1 B SER 17 ? B SER 17 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D5H C05  C Y N 1   
A1D5H C09  C N N 2   
A1D5H C10  C N N 3   
A1D5H C02  C Y N 4   
A1D5H C03  C Y N 5   
A1D5H C04  C Y N 6   
A1D5H C07  C N N 7   
A1D5H C11  C N N 8   
A1D5H C12  C N N 9   
A1D5H C15  C Y N 10  
A1D5H C16  C Y N 11  
A1D5H N01  N N N 12  
A1D5H N06  N N N 13  
A1D5H O08  O N N 14  
A1D5H O13  O N N 15  
A1D5H O14  O N N 16  
A1D5H H1   H N N 17  
A1D5H H2   H N N 18  
A1D5H H3   H N N 19  
A1D5H H4   H N N 20  
A1D5H H5   H N N 21  
A1D5H H6   H N N 22  
A1D5H H7   H N N 23  
A1D5H H8   H N N 24  
A1D5H H9   H N N 25  
A1D5H H10  H N N 26  
A1D5H H11  H N N 27  
A1D5H H12  H N N 28  
A1D5H H13  H N N 29  
A1D5H H14  H N N 30  
A1D5H H15  H N N 31  
A1D5H H16  H N N 32  
ALA   N    N N N 33  
ALA   CA   C N S 34  
ALA   C    C N N 35  
ALA   O    O N N 36  
ALA   CB   C N N 37  
ALA   OXT  O N N 38  
ALA   H    H N N 39  
ALA   H2   H N N 40  
ALA   HA   H N N 41  
ALA   HB1  H N N 42  
ALA   HB2  H N N 43  
ALA   HB3  H N N 44  
ALA   HXT  H N N 45  
ARG   N    N N N 46  
ARG   CA   C N S 47  
ARG   C    C N N 48  
ARG   O    O N N 49  
ARG   CB   C N N 50  
ARG   CG   C N N 51  
ARG   CD   C N N 52  
ARG   NE   N N N 53  
ARG   CZ   C N N 54  
ARG   NH1  N N N 55  
ARG   NH2  N N N 56  
ARG   OXT  O N N 57  
ARG   H    H N N 58  
ARG   H2   H N N 59  
ARG   HA   H N N 60  
ARG   HB2  H N N 61  
ARG   HB3  H N N 62  
ARG   HG2  H N N 63  
ARG   HG3  H N N 64  
ARG   HD2  H N N 65  
ARG   HD3  H N N 66  
ARG   HE   H N N 67  
ARG   HH11 H N N 68  
ARG   HH12 H N N 69  
ARG   HH21 H N N 70  
ARG   HH22 H N N 71  
ARG   HXT  H N N 72  
ASN   N    N N N 73  
ASN   CA   C N S 74  
ASN   C    C N N 75  
ASN   O    O N N 76  
ASN   CB   C N N 77  
ASN   CG   C N N 78  
ASN   OD1  O N N 79  
ASN   ND2  N N N 80  
ASN   OXT  O N N 81  
ASN   H    H N N 82  
ASN   H2   H N N 83  
ASN   HA   H N N 84  
ASN   HB2  H N N 85  
ASN   HB3  H N N 86  
ASN   HD21 H N N 87  
ASN   HD22 H N N 88  
ASN   HXT  H N N 89  
ASP   N    N N N 90  
ASP   CA   C N S 91  
ASP   C    C N N 92  
ASP   O    O N N 93  
ASP   CB   C N N 94  
ASP   CG   C N N 95  
ASP   OD1  O N N 96  
ASP   OD2  O N N 97  
ASP   OXT  O N N 98  
ASP   H    H N N 99  
ASP   H2   H N N 100 
ASP   HA   H N N 101 
ASP   HB2  H N N 102 
ASP   HB3  H N N 103 
ASP   HD2  H N N 104 
ASP   HXT  H N N 105 
CYS   N    N N N 106 
CYS   CA   C N R 107 
CYS   C    C N N 108 
CYS   O    O N N 109 
CYS   CB   C N N 110 
CYS   SG   S N N 111 
CYS   OXT  O N N 112 
CYS   H    H N N 113 
CYS   H2   H N N 114 
CYS   HA   H N N 115 
CYS   HB2  H N N 116 
CYS   HB3  H N N 117 
CYS   HG   H N N 118 
CYS   HXT  H N N 119 
GLN   N    N N N 120 
GLN   CA   C N S 121 
GLN   C    C N N 122 
GLN   O    O N N 123 
GLN   CB   C N N 124 
GLN   CG   C N N 125 
GLN   CD   C N N 126 
GLN   OE1  O N N 127 
GLN   NE2  N N N 128 
GLN   OXT  O N N 129 
GLN   H    H N N 130 
GLN   H2   H N N 131 
GLN   HA   H N N 132 
GLN   HB2  H N N 133 
GLN   HB3  H N N 134 
GLN   HG2  H N N 135 
GLN   HG3  H N N 136 
GLN   HE21 H N N 137 
GLN   HE22 H N N 138 
GLN   HXT  H N N 139 
GLU   N    N N N 140 
GLU   CA   C N S 141 
GLU   C    C N N 142 
GLU   O    O N N 143 
GLU   CB   C N N 144 
GLU   CG   C N N 145 
GLU   CD   C N N 146 
GLU   OE1  O N N 147 
GLU   OE2  O N N 148 
GLU   OXT  O N N 149 
GLU   H    H N N 150 
GLU   H2   H N N 151 
GLU   HA   H N N 152 
GLU   HB2  H N N 153 
GLU   HB3  H N N 154 
GLU   HG2  H N N 155 
GLU   HG3  H N N 156 
GLU   HE2  H N N 157 
GLU   HXT  H N N 158 
GLY   N    N N N 159 
GLY   CA   C N N 160 
GLY   C    C N N 161 
GLY   O    O N N 162 
GLY   OXT  O N N 163 
GLY   H    H N N 164 
GLY   H2   H N N 165 
GLY   HA2  H N N 166 
GLY   HA3  H N N 167 
GLY   HXT  H N N 168 
GOL   C1   C N N 169 
GOL   O1   O N N 170 
GOL   C2   C N N 171 
GOL   O2   O N N 172 
GOL   C3   C N N 173 
GOL   O3   O N N 174 
GOL   H11  H N N 175 
GOL   H12  H N N 176 
GOL   HO1  H N N 177 
GOL   H2   H N N 178 
GOL   HO2  H N N 179 
GOL   H31  H N N 180 
GOL   H32  H N N 181 
GOL   HO3  H N N 182 
HIS   N    N N N 183 
HIS   CA   C N S 184 
HIS   C    C N N 185 
HIS   O    O N N 186 
HIS   CB   C N N 187 
HIS   CG   C Y N 188 
HIS   ND1  N Y N 189 
HIS   CD2  C Y N 190 
HIS   CE1  C Y N 191 
HIS   NE2  N Y N 192 
HIS   OXT  O N N 193 
HIS   H    H N N 194 
HIS   H2   H N N 195 
HIS   HA   H N N 196 
HIS   HB2  H N N 197 
HIS   HB3  H N N 198 
HIS   HD1  H N N 199 
HIS   HD2  H N N 200 
HIS   HE1  H N N 201 
HIS   HE2  H N N 202 
HIS   HXT  H N N 203 
HOH   O    O N N 204 
HOH   H1   H N N 205 
HOH   H2   H N N 206 
ILE   N    N N N 207 
ILE   CA   C N S 208 
ILE   C    C N N 209 
ILE   O    O N N 210 
ILE   CB   C N S 211 
ILE   CG1  C N N 212 
ILE   CG2  C N N 213 
ILE   CD1  C N N 214 
ILE   OXT  O N N 215 
ILE   H    H N N 216 
ILE   H2   H N N 217 
ILE   HA   H N N 218 
ILE   HB   H N N 219 
ILE   HG12 H N N 220 
ILE   HG13 H N N 221 
ILE   HG21 H N N 222 
ILE   HG22 H N N 223 
ILE   HG23 H N N 224 
ILE   HD11 H N N 225 
ILE   HD12 H N N 226 
ILE   HD13 H N N 227 
ILE   HXT  H N N 228 
LEU   N    N N N 229 
LEU   CA   C N S 230 
LEU   C    C N N 231 
LEU   O    O N N 232 
LEU   CB   C N N 233 
LEU   CG   C N N 234 
LEU   CD1  C N N 235 
LEU   CD2  C N N 236 
LEU   OXT  O N N 237 
LEU   H    H N N 238 
LEU   H2   H N N 239 
LEU   HA   H N N 240 
LEU   HB2  H N N 241 
LEU   HB3  H N N 242 
LEU   HG   H N N 243 
LEU   HD11 H N N 244 
LEU   HD12 H N N 245 
LEU   HD13 H N N 246 
LEU   HD21 H N N 247 
LEU   HD22 H N N 248 
LEU   HD23 H N N 249 
LEU   HXT  H N N 250 
LYS   N    N N N 251 
LYS   CA   C N S 252 
LYS   C    C N N 253 
LYS   O    O N N 254 
LYS   CB   C N N 255 
LYS   CG   C N N 256 
LYS   CD   C N N 257 
LYS   CE   C N N 258 
LYS   NZ   N N N 259 
LYS   OXT  O N N 260 
LYS   H    H N N 261 
LYS   H2   H N N 262 
LYS   HA   H N N 263 
LYS   HB2  H N N 264 
LYS   HB3  H N N 265 
LYS   HG2  H N N 266 
LYS   HG3  H N N 267 
LYS   HD2  H N N 268 
LYS   HD3  H N N 269 
LYS   HE2  H N N 270 
LYS   HE3  H N N 271 
LYS   HZ1  H N N 272 
LYS   HZ2  H N N 273 
LYS   HZ3  H N N 274 
LYS   HXT  H N N 275 
MET   N    N N N 276 
MET   CA   C N S 277 
MET   C    C N N 278 
MET   O    O N N 279 
MET   CB   C N N 280 
MET   CG   C N N 281 
MET   SD   S N N 282 
MET   CE   C N N 283 
MET   OXT  O N N 284 
MET   H    H N N 285 
MET   H2   H N N 286 
MET   HA   H N N 287 
MET   HB2  H N N 288 
MET   HB3  H N N 289 
MET   HG2  H N N 290 
MET   HG3  H N N 291 
MET   HE1  H N N 292 
MET   HE2  H N N 293 
MET   HE3  H N N 294 
MET   HXT  H N N 295 
PHE   N    N N N 296 
PHE   CA   C N S 297 
PHE   C    C N N 298 
PHE   O    O N N 299 
PHE   CB   C N N 300 
PHE   CG   C Y N 301 
PHE   CD1  C Y N 302 
PHE   CD2  C Y N 303 
PHE   CE1  C Y N 304 
PHE   CE2  C Y N 305 
PHE   CZ   C Y N 306 
PHE   OXT  O N N 307 
PHE   H    H N N 308 
PHE   H2   H N N 309 
PHE   HA   H N N 310 
PHE   HB2  H N N 311 
PHE   HB3  H N N 312 
PHE   HD1  H N N 313 
PHE   HD2  H N N 314 
PHE   HE1  H N N 315 
PHE   HE2  H N N 316 
PHE   HZ   H N N 317 
PHE   HXT  H N N 318 
PRO   N    N N N 319 
PRO   CA   C N S 320 
PRO   C    C N N 321 
PRO   O    O N N 322 
PRO   CB   C N N 323 
PRO   CG   C N N 324 
PRO   CD   C N N 325 
PRO   OXT  O N N 326 
PRO   H    H N N 327 
PRO   HA   H N N 328 
PRO   HB2  H N N 329 
PRO   HB3  H N N 330 
PRO   HG2  H N N 331 
PRO   HG3  H N N 332 
PRO   HD2  H N N 333 
PRO   HD3  H N N 334 
PRO   HXT  H N N 335 
SER   N    N N N 336 
SER   CA   C N S 337 
SER   C    C N N 338 
SER   O    O N N 339 
SER   CB   C N N 340 
SER   OG   O N N 341 
SER   OXT  O N N 342 
SER   H    H N N 343 
SER   H2   H N N 344 
SER   HA   H N N 345 
SER   HB2  H N N 346 
SER   HB3  H N N 347 
SER   HG   H N N 348 
SER   HXT  H N N 349 
THR   N    N N N 350 
THR   CA   C N S 351 
THR   C    C N N 352 
THR   O    O N N 353 
THR   CB   C N R 354 
THR   OG1  O N N 355 
THR   CG2  C N N 356 
THR   OXT  O N N 357 
THR   H    H N N 358 
THR   H2   H N N 359 
THR   HA   H N N 360 
THR   HB   H N N 361 
THR   HG1  H N N 362 
THR   HG21 H N N 363 
THR   HG22 H N N 364 
THR   HG23 H N N 365 
THR   HXT  H N N 366 
TRP   N    N N N 367 
TRP   CA   C N S 368 
TRP   C    C N N 369 
TRP   O    O N N 370 
TRP   CB   C N N 371 
TRP   CG   C Y N 372 
TRP   CD1  C Y N 373 
TRP   CD2  C Y N 374 
TRP   NE1  N Y N 375 
TRP   CE2  C Y N 376 
TRP   CE3  C Y N 377 
TRP   CZ2  C Y N 378 
TRP   CZ3  C Y N 379 
TRP   CH2  C Y N 380 
TRP   OXT  O N N 381 
TRP   H    H N N 382 
TRP   H2   H N N 383 
TRP   HA   H N N 384 
TRP   HB2  H N N 385 
TRP   HB3  H N N 386 
TRP   HD1  H N N 387 
TRP   HE1  H N N 388 
TRP   HE3  H N N 389 
TRP   HZ2  H N N 390 
TRP   HZ3  H N N 391 
TRP   HH2  H N N 392 
TRP   HXT  H N N 393 
TYR   N    N N N 394 
TYR   CA   C N S 395 
TYR   C    C N N 396 
TYR   O    O N N 397 
TYR   CB   C N N 398 
TYR   CG   C Y N 399 
TYR   CD1  C Y N 400 
TYR   CD2  C Y N 401 
TYR   CE1  C Y N 402 
TYR   CE2  C Y N 403 
TYR   CZ   C Y N 404 
TYR   OH   O N N 405 
TYR   OXT  O N N 406 
TYR   H    H N N 407 
TYR   H2   H N N 408 
TYR   HA   H N N 409 
TYR   HB2  H N N 410 
TYR   HB3  H N N 411 
TYR   HD1  H N N 412 
TYR   HD2  H N N 413 
TYR   HE1  H N N 414 
TYR   HE2  H N N 415 
TYR   HH   H N N 416 
TYR   HXT  H N N 417 
VAL   N    N N N 418 
VAL   CA   C N S 419 
VAL   C    C N N 420 
VAL   O    O N N 421 
VAL   CB   C N N 422 
VAL   CG1  C N N 423 
VAL   CG2  C N N 424 
VAL   OXT  O N N 425 
VAL   H    H N N 426 
VAL   H2   H N N 427 
VAL   HA   H N N 428 
VAL   HB   H N N 429 
VAL   HG11 H N N 430 
VAL   HG12 H N N 431 
VAL   HG13 H N N 432 
VAL   HG21 H N N 433 
VAL   HG22 H N N 434 
VAL   HG23 H N N 435 
VAL   HXT  H N N 436 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D5H O13 C12  sing N N 1   
A1D5H C12 C11  sing N N 2   
A1D5H C11 C10  sing N N 3   
A1D5H C10 C09  sing N N 4   
A1D5H N01 C02  sing N N 5   
A1D5H C03 C02  doub Y N 6   
A1D5H C03 C04  sing Y N 7   
A1D5H C09 O08  sing N N 8   
A1D5H O08 C07  sing N N 9   
A1D5H C02 C16  sing Y N 10  
A1D5H C04 C05  doub Y N 11  
A1D5H C07 O14  doub N N 12  
A1D5H C07 N06  sing N N 13  
A1D5H C16 C15  doub Y N 14  
A1D5H C05 C15  sing Y N 15  
A1D5H C05 N06  sing N N 16  
A1D5H C09 H1   sing N N 17  
A1D5H C09 H2   sing N N 18  
A1D5H C10 H3   sing N N 19  
A1D5H C10 H4   sing N N 20  
A1D5H C03 H5   sing N N 21  
A1D5H C04 H6   sing N N 22  
A1D5H C11 H7   sing N N 23  
A1D5H C11 H8   sing N N 24  
A1D5H C12 H9   sing N N 25  
A1D5H C12 H10  sing N N 26  
A1D5H C15 H11  sing N N 27  
A1D5H C16 H12  sing N N 28  
A1D5H N01 H13  sing N N 29  
A1D5H N01 H14  sing N N 30  
A1D5H N06 H15  sing N N 31  
A1D5H O13 H16  sing N N 32  
ALA   N   CA   sing N N 33  
ALA   N   H    sing N N 34  
ALA   N   H2   sing N N 35  
ALA   CA  C    sing N N 36  
ALA   CA  CB   sing N N 37  
ALA   CA  HA   sing N N 38  
ALA   C   O    doub N N 39  
ALA   C   OXT  sing N N 40  
ALA   CB  HB1  sing N N 41  
ALA   CB  HB2  sing N N 42  
ALA   CB  HB3  sing N N 43  
ALA   OXT HXT  sing N N 44  
ARG   N   CA   sing N N 45  
ARG   N   H    sing N N 46  
ARG   N   H2   sing N N 47  
ARG   CA  C    sing N N 48  
ARG   CA  CB   sing N N 49  
ARG   CA  HA   sing N N 50  
ARG   C   O    doub N N 51  
ARG   C   OXT  sing N N 52  
ARG   CB  CG   sing N N 53  
ARG   CB  HB2  sing N N 54  
ARG   CB  HB3  sing N N 55  
ARG   CG  CD   sing N N 56  
ARG   CG  HG2  sing N N 57  
ARG   CG  HG3  sing N N 58  
ARG   CD  NE   sing N N 59  
ARG   CD  HD2  sing N N 60  
ARG   CD  HD3  sing N N 61  
ARG   NE  CZ   sing N N 62  
ARG   NE  HE   sing N N 63  
ARG   CZ  NH1  sing N N 64  
ARG   CZ  NH2  doub N N 65  
ARG   NH1 HH11 sing N N 66  
ARG   NH1 HH12 sing N N 67  
ARG   NH2 HH21 sing N N 68  
ARG   NH2 HH22 sing N N 69  
ARG   OXT HXT  sing N N 70  
ASN   N   CA   sing N N 71  
ASN   N   H    sing N N 72  
ASN   N   H2   sing N N 73  
ASN   CA  C    sing N N 74  
ASN   CA  CB   sing N N 75  
ASN   CA  HA   sing N N 76  
ASN   C   O    doub N N 77  
ASN   C   OXT  sing N N 78  
ASN   CB  CG   sing N N 79  
ASN   CB  HB2  sing N N 80  
ASN   CB  HB3  sing N N 81  
ASN   CG  OD1  doub N N 82  
ASN   CG  ND2  sing N N 83  
ASN   ND2 HD21 sing N N 84  
ASN   ND2 HD22 sing N N 85  
ASN   OXT HXT  sing N N 86  
ASP   N   CA   sing N N 87  
ASP   N   H    sing N N 88  
ASP   N   H2   sing N N 89  
ASP   CA  C    sing N N 90  
ASP   CA  CB   sing N N 91  
ASP   CA  HA   sing N N 92  
ASP   C   O    doub N N 93  
ASP   C   OXT  sing N N 94  
ASP   CB  CG   sing N N 95  
ASP   CB  HB2  sing N N 96  
ASP   CB  HB3  sing N N 97  
ASP   CG  OD1  doub N N 98  
ASP   CG  OD2  sing N N 99  
ASP   OD2 HD2  sing N N 100 
ASP   OXT HXT  sing N N 101 
CYS   N   CA   sing N N 102 
CYS   N   H    sing N N 103 
CYS   N   H2   sing N N 104 
CYS   CA  C    sing N N 105 
CYS   CA  CB   sing N N 106 
CYS   CA  HA   sing N N 107 
CYS   C   O    doub N N 108 
CYS   C   OXT  sing N N 109 
CYS   CB  SG   sing N N 110 
CYS   CB  HB2  sing N N 111 
CYS   CB  HB3  sing N N 112 
CYS   SG  HG   sing N N 113 
CYS   OXT HXT  sing N N 114 
GLN   N   CA   sing N N 115 
GLN   N   H    sing N N 116 
GLN   N   H2   sing N N 117 
GLN   CA  C    sing N N 118 
GLN   CA  CB   sing N N 119 
GLN   CA  HA   sing N N 120 
GLN   C   O    doub N N 121 
GLN   C   OXT  sing N N 122 
GLN   CB  CG   sing N N 123 
GLN   CB  HB2  sing N N 124 
GLN   CB  HB3  sing N N 125 
GLN   CG  CD   sing N N 126 
GLN   CG  HG2  sing N N 127 
GLN   CG  HG3  sing N N 128 
GLN   CD  OE1  doub N N 129 
GLN   CD  NE2  sing N N 130 
GLN   NE2 HE21 sing N N 131 
GLN   NE2 HE22 sing N N 132 
GLN   OXT HXT  sing N N 133 
GLU   N   CA   sing N N 134 
GLU   N   H    sing N N 135 
GLU   N   H2   sing N N 136 
GLU   CA  C    sing N N 137 
GLU   CA  CB   sing N N 138 
GLU   CA  HA   sing N N 139 
GLU   C   O    doub N N 140 
GLU   C   OXT  sing N N 141 
GLU   CB  CG   sing N N 142 
GLU   CB  HB2  sing N N 143 
GLU   CB  HB3  sing N N 144 
GLU   CG  CD   sing N N 145 
GLU   CG  HG2  sing N N 146 
GLU   CG  HG3  sing N N 147 
GLU   CD  OE1  doub N N 148 
GLU   CD  OE2  sing N N 149 
GLU   OE2 HE2  sing N N 150 
GLU   OXT HXT  sing N N 151 
GLY   N   CA   sing N N 152 
GLY   N   H    sing N N 153 
GLY   N   H2   sing N N 154 
GLY   CA  C    sing N N 155 
GLY   CA  HA2  sing N N 156 
GLY   CA  HA3  sing N N 157 
GLY   C   O    doub N N 158 
GLY   C   OXT  sing N N 159 
GLY   OXT HXT  sing N N 160 
GOL   C1  O1   sing N N 161 
GOL   C1  C2   sing N N 162 
GOL   C1  H11  sing N N 163 
GOL   C1  H12  sing N N 164 
GOL   O1  HO1  sing N N 165 
GOL   C2  O2   sing N N 166 
GOL   C2  C3   sing N N 167 
GOL   C2  H2   sing N N 168 
GOL   O2  HO2  sing N N 169 
GOL   C3  O3   sing N N 170 
GOL   C3  H31  sing N N 171 
GOL   C3  H32  sing N N 172 
GOL   O3  HO3  sing N N 173 
HIS   N   CA   sing N N 174 
HIS   N   H    sing N N 175 
HIS   N   H2   sing N N 176 
HIS   CA  C    sing N N 177 
HIS   CA  CB   sing N N 178 
HIS   CA  HA   sing N N 179 
HIS   C   O    doub N N 180 
HIS   C   OXT  sing N N 181 
HIS   CB  CG   sing N N 182 
HIS   CB  HB2  sing N N 183 
HIS   CB  HB3  sing N N 184 
HIS   CG  ND1  sing Y N 185 
HIS   CG  CD2  doub Y N 186 
HIS   ND1 CE1  doub Y N 187 
HIS   ND1 HD1  sing N N 188 
HIS   CD2 NE2  sing Y N 189 
HIS   CD2 HD2  sing N N 190 
HIS   CE1 NE2  sing Y N 191 
HIS   CE1 HE1  sing N N 192 
HIS   NE2 HE2  sing N N 193 
HIS   OXT HXT  sing N N 194 
HOH   O   H1   sing N N 195 
HOH   O   H2   sing N N 196 
ILE   N   CA   sing N N 197 
ILE   N   H    sing N N 198 
ILE   N   H2   sing N N 199 
ILE   CA  C    sing N N 200 
ILE   CA  CB   sing N N 201 
ILE   CA  HA   sing N N 202 
ILE   C   O    doub N N 203 
ILE   C   OXT  sing N N 204 
ILE   CB  CG1  sing N N 205 
ILE   CB  CG2  sing N N 206 
ILE   CB  HB   sing N N 207 
ILE   CG1 CD1  sing N N 208 
ILE   CG1 HG12 sing N N 209 
ILE   CG1 HG13 sing N N 210 
ILE   CG2 HG21 sing N N 211 
ILE   CG2 HG22 sing N N 212 
ILE   CG2 HG23 sing N N 213 
ILE   CD1 HD11 sing N N 214 
ILE   CD1 HD12 sing N N 215 
ILE   CD1 HD13 sing N N 216 
ILE   OXT HXT  sing N N 217 
LEU   N   CA   sing N N 218 
LEU   N   H    sing N N 219 
LEU   N   H2   sing N N 220 
LEU   CA  C    sing N N 221 
LEU   CA  CB   sing N N 222 
LEU   CA  HA   sing N N 223 
LEU   C   O    doub N N 224 
LEU   C   OXT  sing N N 225 
LEU   CB  CG   sing N N 226 
LEU   CB  HB2  sing N N 227 
LEU   CB  HB3  sing N N 228 
LEU   CG  CD1  sing N N 229 
LEU   CG  CD2  sing N N 230 
LEU   CG  HG   sing N N 231 
LEU   CD1 HD11 sing N N 232 
LEU   CD1 HD12 sing N N 233 
LEU   CD1 HD13 sing N N 234 
LEU   CD2 HD21 sing N N 235 
LEU   CD2 HD22 sing N N 236 
LEU   CD2 HD23 sing N N 237 
LEU   OXT HXT  sing N N 238 
LYS   N   CA   sing N N 239 
LYS   N   H    sing N N 240 
LYS   N   H2   sing N N 241 
LYS   CA  C    sing N N 242 
LYS   CA  CB   sing N N 243 
LYS   CA  HA   sing N N 244 
LYS   C   O    doub N N 245 
LYS   C   OXT  sing N N 246 
LYS   CB  CG   sing N N 247 
LYS   CB  HB2  sing N N 248 
LYS   CB  HB3  sing N N 249 
LYS   CG  CD   sing N N 250 
LYS   CG  HG2  sing N N 251 
LYS   CG  HG3  sing N N 252 
LYS   CD  CE   sing N N 253 
LYS   CD  HD2  sing N N 254 
LYS   CD  HD3  sing N N 255 
LYS   CE  NZ   sing N N 256 
LYS   CE  HE2  sing N N 257 
LYS   CE  HE3  sing N N 258 
LYS   NZ  HZ1  sing N N 259 
LYS   NZ  HZ2  sing N N 260 
LYS   NZ  HZ3  sing N N 261 
LYS   OXT HXT  sing N N 262 
MET   N   CA   sing N N 263 
MET   N   H    sing N N 264 
MET   N   H2   sing N N 265 
MET   CA  C    sing N N 266 
MET   CA  CB   sing N N 267 
MET   CA  HA   sing N N 268 
MET   C   O    doub N N 269 
MET   C   OXT  sing N N 270 
MET   CB  CG   sing N N 271 
MET   CB  HB2  sing N N 272 
MET   CB  HB3  sing N N 273 
MET   CG  SD   sing N N 274 
MET   CG  HG2  sing N N 275 
MET   CG  HG3  sing N N 276 
MET   SD  CE   sing N N 277 
MET   CE  HE1  sing N N 278 
MET   CE  HE2  sing N N 279 
MET   CE  HE3  sing N N 280 
MET   OXT HXT  sing N N 281 
PHE   N   CA   sing N N 282 
PHE   N   H    sing N N 283 
PHE   N   H2   sing N N 284 
PHE   CA  C    sing N N 285 
PHE   CA  CB   sing N N 286 
PHE   CA  HA   sing N N 287 
PHE   C   O    doub N N 288 
PHE   C   OXT  sing N N 289 
PHE   CB  CG   sing N N 290 
PHE   CB  HB2  sing N N 291 
PHE   CB  HB3  sing N N 292 
PHE   CG  CD1  doub Y N 293 
PHE   CG  CD2  sing Y N 294 
PHE   CD1 CE1  sing Y N 295 
PHE   CD1 HD1  sing N N 296 
PHE   CD2 CE2  doub Y N 297 
PHE   CD2 HD2  sing N N 298 
PHE   CE1 CZ   doub Y N 299 
PHE   CE1 HE1  sing N N 300 
PHE   CE2 CZ   sing Y N 301 
PHE   CE2 HE2  sing N N 302 
PHE   CZ  HZ   sing N N 303 
PHE   OXT HXT  sing N N 304 
PRO   N   CA   sing N N 305 
PRO   N   CD   sing N N 306 
PRO   N   H    sing N N 307 
PRO   CA  C    sing N N 308 
PRO   CA  CB   sing N N 309 
PRO   CA  HA   sing N N 310 
PRO   C   O    doub N N 311 
PRO   C   OXT  sing N N 312 
PRO   CB  CG   sing N N 313 
PRO   CB  HB2  sing N N 314 
PRO   CB  HB3  sing N N 315 
PRO   CG  CD   sing N N 316 
PRO   CG  HG2  sing N N 317 
PRO   CG  HG3  sing N N 318 
PRO   CD  HD2  sing N N 319 
PRO   CD  HD3  sing N N 320 
PRO   OXT HXT  sing N N 321 
SER   N   CA   sing N N 322 
SER   N   H    sing N N 323 
SER   N   H2   sing N N 324 
SER   CA  C    sing N N 325 
SER   CA  CB   sing N N 326 
SER   CA  HA   sing N N 327 
SER   C   O    doub N N 328 
SER   C   OXT  sing N N 329 
SER   CB  OG   sing N N 330 
SER   CB  HB2  sing N N 331 
SER   CB  HB3  sing N N 332 
SER   OG  HG   sing N N 333 
SER   OXT HXT  sing N N 334 
THR   N   CA   sing N N 335 
THR   N   H    sing N N 336 
THR   N   H2   sing N N 337 
THR   CA  C    sing N N 338 
THR   CA  CB   sing N N 339 
THR   CA  HA   sing N N 340 
THR   C   O    doub N N 341 
THR   C   OXT  sing N N 342 
THR   CB  OG1  sing N N 343 
THR   CB  CG2  sing N N 344 
THR   CB  HB   sing N N 345 
THR   OG1 HG1  sing N N 346 
THR   CG2 HG21 sing N N 347 
THR   CG2 HG22 sing N N 348 
THR   CG2 HG23 sing N N 349 
THR   OXT HXT  sing N N 350 
TRP   N   CA   sing N N 351 
TRP   N   H    sing N N 352 
TRP   N   H2   sing N N 353 
TRP   CA  C    sing N N 354 
TRP   CA  CB   sing N N 355 
TRP   CA  HA   sing N N 356 
TRP   C   O    doub N N 357 
TRP   C   OXT  sing N N 358 
TRP   CB  CG   sing N N 359 
TRP   CB  HB2  sing N N 360 
TRP   CB  HB3  sing N N 361 
TRP   CG  CD1  doub Y N 362 
TRP   CG  CD2  sing Y N 363 
TRP   CD1 NE1  sing Y N 364 
TRP   CD1 HD1  sing N N 365 
TRP   CD2 CE2  doub Y N 366 
TRP   CD2 CE3  sing Y N 367 
TRP   NE1 CE2  sing Y N 368 
TRP   NE1 HE1  sing N N 369 
TRP   CE2 CZ2  sing Y N 370 
TRP   CE3 CZ3  doub Y N 371 
TRP   CE3 HE3  sing N N 372 
TRP   CZ2 CH2  doub Y N 373 
TRP   CZ2 HZ2  sing N N 374 
TRP   CZ3 CH2  sing Y N 375 
TRP   CZ3 HZ3  sing N N 376 
TRP   CH2 HH2  sing N N 377 
TRP   OXT HXT  sing N N 378 
TYR   N   CA   sing N N 379 
TYR   N   H    sing N N 380 
TYR   N   H2   sing N N 381 
TYR   CA  C    sing N N 382 
TYR   CA  CB   sing N N 383 
TYR   CA  HA   sing N N 384 
TYR   C   O    doub N N 385 
TYR   C   OXT  sing N N 386 
TYR   CB  CG   sing N N 387 
TYR   CB  HB2  sing N N 388 
TYR   CB  HB3  sing N N 389 
TYR   CG  CD1  doub Y N 390 
TYR   CG  CD2  sing Y N 391 
TYR   CD1 CE1  sing Y N 392 
TYR   CD1 HD1  sing N N 393 
TYR   CD2 CE2  doub Y N 394 
TYR   CD2 HD2  sing N N 395 
TYR   CE1 CZ   doub Y N 396 
TYR   CE1 HE1  sing N N 397 
TYR   CE2 CZ   sing Y N 398 
TYR   CE2 HE2  sing N N 399 
TYR   CZ  OH   sing N N 400 
TYR   OH  HH   sing N N 401 
TYR   OXT HXT  sing N N 402 
VAL   N   CA   sing N N 403 
VAL   N   H    sing N N 404 
VAL   N   H2   sing N N 405 
VAL   CA  C    sing N N 406 
VAL   CA  CB   sing N N 407 
VAL   CA  HA   sing N N 408 
VAL   C   O    doub N N 409 
VAL   C   OXT  sing N N 410 
VAL   CB  CG1  sing N N 411 
VAL   CB  CG2  sing N N 412 
VAL   CB  HB   sing N N 413 
VAL   CG1 HG11 sing N N 414 
VAL   CG1 HG12 sing N N 415 
VAL   CG1 HG13 sing N N 416 
VAL   CG2 HG21 sing N N 417 
VAL   CG2 HG22 sing N N 418 
VAL   CG2 HG23 sing N N 419 
VAL   OXT HXT  sing N N 420 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8XTC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011521 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011521 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003614 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA   A 1 15  ? -22.271 -14.938 0.922   1.00 54.30 ? 15  ALA   A N   1 
ATOM   2    C CA  . ALA   A 1 15  ? -20.942 -15.315 0.456   1.00 58.52 ? 15  ALA   A CA  1 
ATOM   3    C C   . ALA   A 1 15  ? -20.019 -14.101 0.395   1.00 60.12 ? 15  ALA   A C   1 
ATOM   4    O O   . ALA   A 1 15  ? -20.413 -12.987 0.744   1.00 56.65 ? 15  ALA   A O   1 
ATOM   5    C CB  . ALA   A 1 15  ? -21.027 -15.987 -0.912  1.00 55.98 ? 15  ALA   A CB  1 
ATOM   6    N N   . MET   A 1 16  ? -18.785 -14.327 -0.045  1.00 59.57 ? 16  MET   A N   1 
ATOM   7    C CA  . MET   A 1 16  ? -17.804 -13.270 -0.235  1.00 58.53 ? 16  MET   A CA  1 
ATOM   8    C C   . MET   A 1 16  ? -17.500 -13.132 -1.722  1.00 59.72 ? 16  MET   A C   1 
ATOM   9    O O   . MET   A 1 16  ? -17.373 -14.134 -2.432  1.00 62.89 ? 16  MET   A O   1 
ATOM   10   C CB  . MET   A 1 16  ? -16.526 -13.566 0.556   1.00 58.76 ? 16  MET   A CB  1 
ATOM   11   C CG  . MET   A 1 16  ? -16.748 -14.470 1.763   1.00 57.13 ? 16  MET   A CG  1 
ATOM   12   S SD  . MET   A 1 16  ? -15.562 -14.189 3.090   1.00 62.65 ? 16  MET   A SD  1 
ATOM   13   C CE  . MET   A 1 16  ? -14.027 -14.162 2.169   1.00 57.97 ? 16  MET   A CE  1 
ATOM   14   N N   . SER   A 1 17  ? -17.396 -11.892 -2.195  1.00 54.71 ? 17  SER   A N   1 
ATOM   15   C CA  . SER   A 1 17  ? -17.318 -11.617 -3.621  1.00 53.75 ? 17  SER   A CA  1 
ATOM   16   C C   . SER   A 1 17  ? -16.031 -10.880 -3.969  1.00 53.58 ? 17  SER   A C   1 
ATOM   17   O O   . SER   A 1 17  ? -15.394 -10.250 -3.121  1.00 54.55 ? 17  SER   A O   1 
ATOM   18   C CB  . SER   A 1 17  ? -18.525 -10.791 -4.091  1.00 55.60 ? 17  SER   A CB  1 
ATOM   19   O OG  . SER   A 1 17  ? -18.515 -9.493  -3.520  1.00 56.58 ? 17  SER   A OG  1 
ATOM   20   N N   . GLU   A 1 18  ? -15.658 -10.977 -5.243  1.00 50.46 ? 18  GLU   A N   1 
ATOM   21   C CA  . GLU   A 1 18  ? -14.556 -10.226 -5.822  1.00 48.26 ? 18  GLU   A CA  1 
ATOM   22   C C   . GLU   A 1 18  ? -15.029 -9.613  -7.132  1.00 50.92 ? 18  GLU   A C   1 
ATOM   23   O O   . GLU   A 1 18  ? -16.131 -9.892  -7.610  1.00 47.52 ? 18  GLU   A O   1 
ATOM   24   C CB  . GLU   A 1 18  ? -13.325 -11.112 -6.062  1.00 45.56 ? 18  GLU   A CB  1 
ATOM   25   C CG  . GLU   A 1 18  ? -12.890 -11.928 -4.857  1.00 49.76 ? 18  GLU   A CG  1 
ATOM   26   C CD  . GLU   A 1 18  ? -12.273 -11.084 -3.760  1.00 51.11 ? 18  GLU   A CD  1 
ATOM   27   O OE1 . GLU   A 1 18  ? -11.960 -9.900  -4.013  1.00 51.90 ? 18  GLU   A OE1 1 
ATOM   28   O OE2 . GLU   A 1 18  ? -12.094 -11.606 -2.640  1.00 50.28 ? 18  GLU   A OE2 1 
ATOM   29   N N   . LEU   A 1 19  ? -14.185 -8.769  -7.717  1.00 49.48 ? 19  LEU   A N   1 
ATOM   30   C CA  . LEU   A 1 19  ? -14.505 -8.202  -9.019  1.00 48.61 ? 19  LEU   A CA  1 
ATOM   31   C C   . LEU   A 1 19  ? -14.298 -9.244  -10.108 1.00 48.79 ? 19  LEU   A C   1 
ATOM   32   O O   . LEU   A 1 19  ? -13.370 -10.056 -10.048 1.00 47.81 ? 19  LEU   A O   1 
ATOM   33   C CB  . LEU   A 1 19  ? -13.638 -6.978  -9.311  1.00 49.02 ? 19  LEU   A CB  1 
ATOM   34   C CG  . LEU   A 1 19  ? -13.700 -5.793  -8.350  1.00 49.89 ? 19  LEU   A CG  1 
ATOM   35   C CD1 . LEU   A 1 19  ? -13.052 -4.577  -8.991  1.00 48.67 ? 19  LEU   A CD1 1 
ATOM   36   C CD2 . LEU   A 1 19  ? -15.131 -5.493  -7.940  1.00 50.19 ? 19  LEU   A CD2 1 
ATOM   37   N N   . SER   A 1 20  ? -15.171 -9.224  -11.107 1.00 47.62 ? 20  SER   A N   1 
ATOM   38   C CA  . SER   A 1 20  ? -14.913 -10.031 -12.284 1.00 48.35 ? 20  SER   A CA  1 
ATOM   39   C C   . SER   A 1 20  ? -13.788 -9.403  -13.103 1.00 48.02 ? 20  SER   A C   1 
ATOM   40   O O   . SER   A 1 20  ? -13.267 -8.328  -12.780 1.00 47.05 ? 20  SER   A O   1 
ATOM   41   C CB  . SER   A 1 20  ? -16.179 -10.177 -13.129 1.00 48.77 ? 20  SER   A CB  1 
ATOM   42   O OG  . SER   A 1 20  ? -16.584 -8.926  -13.646 1.00 47.13 ? 20  SER   A OG  1 
ATOM   43   N N   . ALA   A 1 21  ? -13.400 -10.105 -14.170 1.00 47.87 ? 21  ALA   A N   1 
ATOM   44   C CA  . ALA   A 1 21  ? -12.381 -9.576  -15.068 1.00 45.31 ? 21  ALA   A CA  1 
ATOM   45   C C   . ALA   A 1 21  ? -12.836 -8.272  -15.710 1.00 45.57 ? 21  ALA   A C   1 
ATOM   46   O O   . ALA   A 1 21  ? -12.066 -7.308  -15.791 1.00 47.23 ? 21  ALA   A O   1 
ATOM   47   C CB  . ALA   A 1 21  ? -12.042 -10.616 -16.137 1.00 47.84 ? 21  ALA   A CB  1 
ATOM   48   N N   . ILE   A 1 22  ? -14.090 -8.219  -16.163 1.00 47.93 ? 22  ILE   A N   1 
ATOM   49   C CA  . ILE   A 1 22  ? -14.595 -7.013  -16.812 1.00 48.94 ? 22  ILE   A CA  1 
ATOM   50   C C   . ILE   A 1 22  ? -14.814 -5.905  -15.789 1.00 50.50 ? 22  ILE   A C   1 
ATOM   51   O O   . ILE   A 1 22  ? -14.524 -4.732  -16.051 1.00 48.86 ? 22  ILE   A O   1 
ATOM   52   C CB  . ILE   A 1 22  ? -15.880 -7.330  -17.599 1.00 47.04 ? 22  ILE   A CB  1 
ATOM   53   C CG1 . ILE   A 1 22  ? -15.572 -8.309  -18.733 1.00 45.72 ? 22  ILE   A CG1 1 
ATOM   54   C CG2 . ILE   A 1 22  ? -16.506 -6.056  -18.146 1.00 44.33 ? 22  ILE   A CG2 1 
ATOM   55   C CD1 . ILE   A 1 22  ? -16.793 -8.761  -19.504 1.00 45.84 ? 22  ILE   A CD1 1 
ATOM   56   N N   . GLU   A 1 23  ? -15.316 -6.259  -14.604 1.00 46.91 ? 23  GLU   A N   1 
ATOM   57   C CA  . GLU   A 1 23  ? -15.496 -5.265  -13.550 1.00 48.67 ? 23  GLU   A CA  1 
ATOM   58   C C   . GLU   A 1 23  ? -14.167 -4.640  -13.146 1.00 48.51 ? 23  GLU   A C   1 
ATOM   59   O O   . GLU   A 1 23  ? -14.101 -3.440  -12.854 1.00 48.78 ? 23  GLU   A O   1 
ATOM   60   C CB  . GLU   A 1 23  ? -16.176 -5.899  -12.335 1.00 47.90 ? 23  GLU   A CB  1 
ATOM   61   C CG  . GLU   A 1 23  ? -17.667 -6.144  -12.487 1.00 48.78 ? 23  GLU   A CG  1 
ATOM   62   C CD  . GLU   A 1 23  ? -18.256 -6.876  -11.297 1.00 53.30 ? 23  GLU   A CD  1 
ATOM   63   O OE1 . GLU   A 1 23  ? -17.480 -7.370  -10.451 1.00 53.48 ? 23  GLU   A OE1 1 
ATOM   64   O OE2 . GLU   A 1 23  ? -19.495 -6.957  -11.204 1.00 56.21 ? 23  GLU   A OE2 1 
ATOM   65   N N   . THR   A 1 24  ? -13.099 -5.440  -13.114 1.00 47.24 ? 24  THR   A N   1 
ATOM   66   C CA  . THR   A 1 24  ? -11.785 -4.918  -12.753 1.00 48.68 ? 24  THR   A CA  1 
ATOM   67   C C   . THR   A 1 24  ? -11.297 -3.906  -13.782 1.00 48.37 ? 24  THR   A C   1 
ATOM   68   O O   . THR   A 1 24  ? -10.815 -2.823  -13.427 1.00 47.81 ? 24  THR   A O   1 
ATOM   69   C CB  . THR   A 1 24  ? -10.787 -6.068  -12.612 1.00 45.64 ? 24  THR   A CB  1 
ATOM   70   O OG1 . THR   A 1 24  ? -11.259 -6.998  -11.628 1.00 46.42 ? 24  THR   A OG1 1 
ATOM   71   C CG2 . THR   A 1 24  ? -9.423  -5.547  -12.194 1.00 47.67 ? 24  THR   A CG2 1 
ATOM   72   N N   . ALA   A 1 25  ? -11.413 -4.245  -15.069 1.00 47.82 ? 25  ALA   A N   1 
ATOM   73   C CA  . ALA   A 1 25  ? -11.040 -3.299  -16.116 1.00 49.77 ? 25  ALA   A CA  1 
ATOM   74   C C   . ALA   A 1 25  ? -11.904 -2.046  -16.055 1.00 50.99 ? 25  ALA   A C   1 
ATOM   75   O O   . ALA   A 1 25  ? -11.429 -0.939  -16.333 1.00 49.99 ? 25  ALA   A O   1 
ATOM   76   C CB  . ALA   A 1 25  ? -11.150 -3.961  -17.487 1.00 47.55 ? 25  ALA   A CB  1 
ATOM   77   N N   . ALA   A 1 26  ? -13.179 -2.202  -15.692 1.00 50.51 ? 26  ALA   A N   1 
ATOM   78   C CA  . ALA   A 1 26  ? -14.059 -1.047  -15.555 1.00 49.19 ? 26  ALA   A CA  1 
ATOM   79   C C   . ALA   A 1 26  ? -13.607 -0.147  -14.414 1.00 48.80 ? 26  ALA   A C   1 
ATOM   80   O O   . ALA   A 1 26  ? -13.626 1.083   -14.538 1.00 47.25 ? 26  ALA   A O   1 
ATOM   81   C CB  . ALA   A 1 26  ? -15.501 -1.510  -15.338 1.00 46.64 ? 26  ALA   A CB  1 
ATOM   82   N N   . ALA   A 1 27  ? -13.192 -0.746  -13.294 1.00 45.94 ? 27  ALA   A N   1 
ATOM   83   C CA  . ALA   A 1 27  ? -12.723 0.042   -12.160 1.00 49.60 ? 27  ALA   A CA  1 
ATOM   84   C C   . ALA   A 1 27  ? -11.433 0.777   -12.494 1.00 47.91 ? 27  ALA   A C   1 
ATOM   85   O O   . ALA   A 1 27  ? -11.255 1.938   -12.105 1.00 48.33 ? 27  ALA   A O   1 
ATOM   86   C CB  . ALA   A 1 27  ? -12.529 -0.861  -10.941 1.00 48.45 ? 27  ALA   A CB  1 
ATOM   87   N N   . ILE   A 1 28  ? -10.521 0.116   -13.210 1.00 48.45 ? 28  ILE   A N   1 
ATOM   88   C CA  . ILE   A 1 28  ? -9.272  0.761   -13.601 1.00 49.51 ? 28  ILE   A CA  1 
ATOM   89   C C   . ILE   A 1 28  ? -9.541  1.876   -14.603 1.00 49.40 ? 28  ILE   A C   1 
ATOM   90   O O   . ILE   A 1 28  ? -8.973  2.970   -14.504 1.00 51.10 ? 28  ILE   A O   1 
ATOM   91   C CB  . ILE   A 1 28  ? -8.287  -0.279  -14.163 1.00 50.13 ? 28  ILE   A CB  1 
ATOM   92   C CG1 . ILE   A 1 28  ? -7.922  -1.301  -13.088 1.00 50.55 ? 28  ILE   A CG1 1 
ATOM   93   C CG2 . ILE   A 1 28  ? -7.038  0.401   -14.710 1.00 49.70 ? 28  ILE   A CG2 1 
ATOM   94   C CD1 . ILE   A 1 28  ? -7.014  -2.402  -13.579 1.00 51.16 ? 28  ILE   A CD1 1 
ATOM   95   N N   . ALA   A 1 29  ? -10.414 1.621   -15.580 1.00 46.59 ? 29  ALA   A N   1 
ATOM   96   C CA  . ALA   A 1 29  ? -10.724 2.638   -16.579 1.00 48.74 ? 29  ALA   A CA  1 
ATOM   97   C C   . ALA   A 1 29  ? -11.477 3.811   -15.965 1.00 47.62 ? 29  ALA   A C   1 
ATOM   98   O O   . ALA   A 1 29  ? -11.295 4.959   -16.384 1.00 47.58 ? 29  ALA   A O   1 
ATOM   99   C CB  . ALA   A 1 29  ? -11.530 2.022   -17.722 1.00 45.08 ? 29  ALA   A CB  1 
ATOM   100  N N   . GLY   A 1 30  ? -12.328 3.545   -14.970 1.00 46.23 ? 30  GLY   A N   1 
ATOM   101  C CA  . GLY   A 1 30  ? -13.099 4.604   -14.343 1.00 46.96 ? 30  GLY   A CA  1 
ATOM   102  C C   . GLY   A 1 30  ? -12.341 5.417   -13.316 1.00 49.65 ? 30  GLY   A C   1 
ATOM   103  O O   . GLY   A 1 30  ? -12.770 6.524   -12.978 1.00 47.00 ? 30  GLY   A O   1 
ATOM   104  N N   . GLY   A 1 31  ? -11.230 4.892   -12.803 1.00 50.29 ? 31  GLY   A N   1 
ATOM   105  C CA  . GLY   A 1 31  ? -10.422 5.605   -11.838 1.00 48.89 ? 31  GLY   A CA  1 
ATOM   106  C C   . GLY   A 1 31  ? -10.713 5.292   -10.388 1.00 52.50 ? 31  GLY   A C   1 
ATOM   107  O O   . GLY   A 1 31  ? -10.045 5.851   -9.509  1.00 53.46 ? 31  GLY   A O   1 
ATOM   108  N N   . SER   A 1 32  ? -11.689 4.424   -10.104 1.00 51.32 ? 32  SER   A N   1 
ATOM   109  C CA  . SER   A 1 32  ? -11.948 4.028   -8.724  1.00 52.06 ? 32  SER   A CA  1 
ATOM   110  C C   . SER   A 1 32  ? -10.786 3.243   -8.131  1.00 55.67 ? 32  SER   A C   1 
ATOM   111  O O   . SER   A 1 32  ? -10.651 3.187   -6.904  1.00 57.25 ? 32  SER   A O   1 
ATOM   112  C CB  . SER   A 1 32  ? -13.234 3.204   -8.638  1.00 50.27 ? 32  SER   A CB  1 
ATOM   113  O OG  . SER   A 1 32  ? -13.123 2.001   -9.376  1.00 51.11 ? 32  SER   A OG  1 
ATOM   114  N N   . MET   A 1 33  ? -9.954  2.637   -8.974  1.00 54.69 ? 33  MET   A N   1 
ATOM   115  C CA  . MET   A 1 33  ? -8.710  2.016   -8.541  1.00 56.94 ? 33  MET   A CA  1 
ATOM   116  C C   . MET   A 1 33  ? -7.756  2.005   -9.728  1.00 55.45 ? 33  MET   A C   1 
ATOM   117  O O   . MET   A 1 33  ? -8.148  2.269   -10.868 1.00 56.40 ? 33  MET   A O   1 
ATOM   118  C CB  . MET   A 1 33  ? -8.938  0.599   -8.003  1.00 55.71 ? 33  MET   A CB  1 
ATOM   119  C CG  . MET   A 1 33  ? -9.198  -0.438  -9.082  1.00 56.68 ? 33  MET   A CG  1 
ATOM   120  S SD  . MET   A 1 33  ? -9.243  -2.127  -8.449  1.00 64.63 ? 33  MET   A SD  1 
ATOM   121  C CE  . MET   A 1 33  ? -10.722 -2.077  -7.441  1.00 52.29 ? 33  MET   A CE  1 
ATOM   122  N N   . THR   A 1 34  ? -6.494  1.697   -9.448  1.00 57.39 ? 34  THR   A N   1 
ATOM   123  C CA  . THR   A 1 34  ? -5.468  1.651   -10.477 1.00 57.87 ? 34  THR   A CA  1 
ATOM   124  C C   . THR   A 1 34  ? -5.027  0.212   -10.716 1.00 57.27 ? 34  THR   A C   1 
ATOM   125  O O   . THR   A 1 34  ? -5.399  -0.711  -9.987  1.00 54.15 ? 34  THR   A O   1 
ATOM   126  C CB  . THR   A 1 34  ? -4.268  2.524   -10.094 1.00 57.11 ? 34  THR   A CB  1 
ATOM   127  O OG1 . THR   A 1 34  ? -3.501  1.867   -9.079  1.00 58.98 ? 34  THR   A OG1 1 
ATOM   128  C CG2 . THR   A 1 34  ? -4.739  3.875   -9.572  1.00 58.00 ? 34  THR   A CG2 1 
ATOM   129  N N   . ALA   A 1 35  ? -4.220  0.033   -11.765 1.00 52.70 ? 35  ALA   A N   1 
ATOM   130  C CA  . ALA   A 1 35  ? -3.731  -1.300  -12.104 1.00 52.87 ? 35  ALA   A CA  1 
ATOM   131  C C   . ALA   A 1 35  ? -2.801  -1.838  -11.023 1.00 55.11 ? 35  ALA   A C   1 
ATOM   132  O O   . ALA   A 1 35  ? -2.840  -3.031  -10.697 1.00 53.39 ? 35  ALA   A O   1 
ATOM   133  C CB  . ALA   A 1 35  ? -3.024  -1.269  -13.459 1.00 51.88 ? 35  ALA   A CB  1 
ATOM   134  N N   . LEU   A 1 36  ? -1.962  -0.972  -10.449 1.00 53.08 ? 36  LEU   A N   1 
ATOM   135  C CA  . LEU   A 1 36  ? -1.072  -1.403  -9.377  1.00 54.35 ? 36  LEU   A CA  1 
ATOM   136  C C   . LEU   A 1 36  ? -1.846  -1.755  -8.113  1.00 53.15 ? 36  LEU   A C   1 
ATOM   137  O O   . LEU   A 1 36  ? -1.409  -2.613  -7.339  1.00 50.31 ? 36  LEU   A O   1 
ATOM   138  C CB  . LEU   A 1 36  ? -0.038  -0.313  -9.087  1.00 55.38 ? 36  LEU   A CB  1 
ATOM   139  C CG  . LEU   A 1 36  ? 1.178   -0.739  -8.265  1.00 57.42 ? 36  LEU   A CG  1 
ATOM   140  C CD1 . LEU   A 1 36  ? 1.927   -1.851  -8.979  1.00 56.74 ? 36  LEU   A CD1 1 
ATOM   141  C CD2 . LEU   A 1 36  ? 2.098   0.442   -7.985  1.00 52.39 ? 36  LEU   A CD2 1 
ATOM   142  N N   . GLU   A 1 37  ? -2.993  -1.111  -7.885  1.00 54.87 ? 37  GLU   A N   1 
ATOM   143  C CA  . GLU   A 1 37  ? -3.789  -1.435  -6.706  1.00 53.37 ? 37  GLU   A CA  1 
ATOM   144  C C   . GLU   A 1 37  ? -4.516  -2.762  -6.879  1.00 52.19 ? 37  GLU   A C   1 
ATOM   145  O O   . GLU   A 1 37  ? -4.603  -3.557  -5.936  1.00 53.08 ? 37  GLU   A O   1 
ATOM   146  C CB  . GLU   A 1 37  ? -4.779  -0.307  -6.416  1.00 56.47 ? 37  GLU   A CB  1 
ATOM   147  C CG  . GLU   A 1 37  ? -4.122  1.005   -6.019  1.00 62.21 ? 37  GLU   A CG  1 
ATOM   148  C CD  . GLU   A 1 37  ? -5.131  2.091   -5.723  1.00 65.18 ? 37  GLU   A CD  1 
ATOM   149  O OE1 . GLU   A 1 37  ? -6.223  2.072   -6.327  1.00 62.34 ? 37  GLU   A OE1 1 
ATOM   150  O OE2 . GLU   A 1 37  ? -4.835  2.963   -4.883  1.00 62.66 ? 37  GLU   A OE2 1 
ATOM   151  N N   . ALA   A 1 38  ? -5.045  -3.018  -8.078  1.00 54.87 ? 38  ALA   A N   1 
ATOM   152  C CA  . ALA   A 1 38  ? -5.674  -4.306  -8.351  1.00 52.80 ? 38  ALA   A CA  1 
ATOM   153  C C   . ALA   A 1 38  ? -4.647  -5.431  -8.358  1.00 53.37 ? 38  ALA   A C   1 
ATOM   154  O O   . ALA   A 1 38  ? -4.930  -6.541  -7.894  1.00 51.81 ? 38  ALA   A O   1 
ATOM   155  C CB  . ALA   A 1 38  ? -6.421  -4.252  -9.684  1.00 50.12 ? 38  ALA   A CB  1 
ATOM   156  N N   . CYS   A 1 39  ? -3.449  -5.164  -8.884  1.00 53.84 ? 39  CYS   A N   1 
ATOM   157  C CA  . CYS   A 1 39  ? -2.398  -6.177  -8.884  1.00 50.45 ? 39  CYS   A CA  1 
ATOM   158  C C   . CYS   A 1 39  ? -1.943  -6.497  -7.466  1.00 52.21 ? 39  CYS   A C   1 
ATOM   159  O O   . CYS   A 1 39  ? -1.765  -7.668  -7.113  1.00 51.54 ? 39  CYS   A O   1 
ATOM   160  C CB  . CYS   A 1 39  ? -1.218  -5.706  -9.734  1.00 52.37 ? 39  CYS   A CB  1 
ATOM   161  S SG  . CYS   A 1 39  ? 0.245   -6.759  -9.623  1.00 56.90 ? 39  CYS   A SG  1 
ATOM   162  N N   . ASP   A 1 40  ? -1.752  -5.466  -6.638  1.00 53.48 ? 40  ASP   A N   1 
ATOM   163  C CA  . ASP   A 1 40  ? -1.343  -5.690  -5.255  1.00 49.93 ? 40  ASP   A CA  1 
ATOM   164  C C   . ASP   A 1 40  ? -2.441  -6.380  -4.455  1.00 48.32 ? 40  ASP   A C   1 
ATOM   165  O O   . ASP   A 1 40  ? -2.151  -7.186  -3.562  1.00 50.43 ? 40  ASP   A O   1 
ATOM   166  C CB  . ASP   A 1 40  ? -0.956  -4.364  -4.598  1.00 48.09 ? 40  ASP   A CB  1 
ATOM   167  C CG  . ASP   A 1 40  ? 0.388   -3.847  -5.075  1.00 51.61 ? 40  ASP   A CG  1 
ATOM   168  O OD1 . ASP   A 1 40  ? 1.213   -4.666  -5.530  1.00 50.90 ? 40  ASP   A OD1 1 
ATOM   169  O OD2 . ASP   A 1 40  ? 0.623   -2.623  -4.988  1.00 51.51 ? 40  ASP   A OD2 1 
ATOM   170  N N   . ALA   A 1 41  ? -3.708  -6.075  -4.755  1.00 48.43 ? 41  ALA   A N   1 
ATOM   171  C CA  . ALA   A 1 41  ? -4.805  -6.753  -4.074  1.00 45.72 ? 41  ALA   A CA  1 
ATOM   172  C C   . ALA   A 1 41  ? -4.831  -8.236  -4.420  1.00 47.83 ? 41  ALA   A C   1 
ATOM   173  O O   . ALA   A 1 41  ? -5.113  -9.078  -3.560  1.00 50.24 ? 41  ALA   A O   1 
ATOM   174  C CB  . ALA   A 1 41  ? -6.136  -6.092  -4.430  1.00 46.90 ? 41  ALA   A CB  1 
ATOM   175  N N   . ALA   A 1 42  ? -4.529  -8.575  -5.674  1.00 48.23 ? 42  ALA   A N   1 
ATOM   176  C CA  . ALA   A 1 42  ? -4.497  -9.978  -6.071  1.00 46.93 ? 42  ALA   A CA  1 
ATOM   177  C C   . ALA   A 1 42  ? -3.311  -10.702 -5.447  1.00 45.87 ? 42  ALA   A C   1 
ATOM   178  O O   . ALA   A 1 42  ? -3.423  -11.875 -5.073  1.00 44.15 ? 42  ALA   A O   1 
ATOM   179  C CB  . ALA   A 1 42  ? -4.459  -10.091 -7.594  1.00 43.85 ? 42  ALA   A CB  1 
ATOM   180  N N   . ILE   A 1 43  ? -2.167  -10.022 -5.331  1.00 47.37 ? 43  ILE   A N   1 
ATOM   181  C CA  . ILE   A 1 43  ? -1.004  -10.623 -4.680  1.00 46.96 ? 43  ILE   A CA  1 
ATOM   182  C C   . ILE   A 1 43  ? -1.316  -10.923 -3.219  1.00 48.60 ? 43  ILE   A C   1 
ATOM   183  O O   . ILE   A 1 43  ? -1.009  -12.006 -2.706  1.00 52.13 ? 43  ILE   A O   1 
ATOM   184  C CB  . ILE   A 1 43  ? 0.225   -9.705  -4.813  1.00 46.63 ? 43  ILE   A CB  1 
ATOM   185  C CG1 . ILE   A 1 43  ? 0.687   -9.623  -6.269  1.00 49.74 ? 43  ILE   A CG1 1 
ATOM   186  C CG2 . ILE   A 1 43  ? 1.356   -10.193 -3.918  1.00 47.18 ? 43  ILE   A CG2 1 
ATOM   187  C CD1 . ILE   A 1 43  ? 1.945   -8.799  -6.464  1.00 48.54 ? 43  ILE   A CD1 1 
ATOM   188  N N   . ALA   A 1 44  ? -1.942  -9.965  -2.531  1.00 48.02 ? 44  ALA   A N   1 
ATOM   189  C CA  . ALA   A 1 44  ? -2.281  -10.156 -1.125  1.00 48.90 ? 44  ALA   A CA  1 
ATOM   190  C C   . ALA   A 1 44  ? -3.294  -11.280 -0.946  1.00 49.97 ? 44  ALA   A C   1 
ATOM   191  O O   . ALA   A 1 44  ? -3.206  -12.059 0.008   1.00 46.90 ? 44  ALA   A O   1 
ATOM   192  C CB  . ALA   A 1 44  ? -2.820  -8.853  -0.537  1.00 44.11 ? 44  ALA   A CB  1 
ATOM   193  N N   . ARG   A 1 45  ? -4.269  -11.378 -1.853  1.00 46.64 ? 45  ARG   A N   1 
ATOM   194  C CA  . ARG   A 1 45  ? -5.250  -12.456 -1.770  1.00 47.31 ? 45  ARG   A CA  1 
ATOM   195  C C   . ARG   A 1 45  ? -4.589  -13.816 -1.942  1.00 47.22 ? 45  ARG   A C   1 
ATOM   196  O O   . ARG   A 1 45  ? -4.970  -14.788 -1.280  1.00 46.01 ? 45  ARG   A O   1 
ATOM   197  C CB  . ARG   A 1 45  ? -6.345  -12.257 -2.820  1.00 47.00 ? 45  ARG   A CB  1 
ATOM   198  C CG  . ARG   A 1 45  ? -7.338  -11.161 -2.489  1.00 45.97 ? 45  ARG   A CG  1 
ATOM   199  C CD  . ARG   A 1 45  ? -8.541  -11.237 -3.415  1.00 50.49 ? 45  ARG   A CD  1 
ATOM   200  N NE  . ARG   A 1 45  ? -8.158  -11.172 -4.821  1.00 46.70 ? 45  ARG   A NE  1 
ATOM   201  C CZ  . ARG   A 1 45  ? -8.175  -10.066 -5.552  1.00 46.41 ? 45  ARG   A CZ  1 
ATOM   202  N NH1 . ARG   A 1 45  ? -8.567  -8.908  -5.046  1.00 45.63 ? 45  ARG   A NH1 1 
ATOM   203  N NH2 . ARG   A 1 45  ? -7.787  -10.122 -6.824  1.00 45.06 ? 45  ARG   A NH2 1 
ATOM   204  N N   . ILE   A 1 46  ? -3.597  -13.905 -2.828  1.00 45.91 ? 46  ILE   A N   1 
ATOM   205  C CA  . ILE   A 1 46  ? -2.893  -15.167 -3.028  1.00 47.12 ? 46  ILE   A CA  1 
ATOM   206  C C   . ILE   A 1 46  ? -2.085  -15.525 -1.789  1.00 49.33 ? 46  ILE   A C   1 
ATOM   207  O O   . ILE   A 1 46  ? -2.191  -16.635 -1.259  1.00 49.53 ? 46  ILE   A O   1 
ATOM   208  C CB  . ILE   A 1 46  ? -1.999  -15.091 -4.278  1.00 44.83 ? 46  ILE   A CB  1 
ATOM   209  C CG1 . ILE   A 1 46  ? -2.854  -14.956 -5.540  1.00 44.79 ? 46  ILE   A CG1 1 
ATOM   210  C CG2 . ILE   A 1 46  ? -1.109  -16.319 -4.373  1.00 45.26 ? 46  ILE   A CG2 1 
ATOM   211  C CD1 . ILE   A 1 46  ? -2.046  -14.698 -6.791  1.00 40.39 ? 46  ILE   A CD1 1 
ATOM   212  N N   . GLU   A 1 47  ? -1.277  -14.585 -1.300  1.00 50.09 ? 47  GLU   A N   1 
ATOM   213  C CA  . GLU   A 1 47  ? -0.460  -14.853 -0.123  1.00 50.11 ? 47  GLU   A CA  1 
ATOM   214  C C   . GLU   A 1 47  ? -1.302  -15.096 1.124   1.00 50.77 ? 47  GLU   A C   1 
ATOM   215  O O   . GLU   A 1 47  ? -0.800  -15.673 2.093   1.00 53.97 ? 47  GLU   A O   1 
ATOM   216  C CB  . GLU   A 1 47  ? 0.514   -13.695 0.114   1.00 51.92 ? 47  GLU   A CB  1 
ATOM   217  C CG  . GLU   A 1 47  ? 1.506   -13.468 -1.022  1.00 53.39 ? 47  GLU   A CG  1 
ATOM   218  C CD  . GLU   A 1 47  ? 2.441   -12.303 -0.758  1.00 59.19 ? 47  GLU   A CD  1 
ATOM   219  O OE1 . GLU   A 1 47  ? 2.096   -11.437 0.071   1.00 59.25 ? 47  GLU   A OE1 1 
ATOM   220  O OE2 . GLU   A 1 47  ? 3.524   -12.256 -1.376  1.00 62.37 ? 47  GLU   A OE2 1 
ATOM   221  N N   . GLN   A 1 48  ? -2.569  -14.680 1.120   1.00 51.30 ? 48  GLN   A N   1 
ATOM   222  C CA  . GLN   A 1 48  ? -3.432  -14.882 2.276   1.00 48.04 ? 48  GLN   A CA  1 
ATOM   223  C C   . GLN   A 1 48  ? -4.242  -16.168 2.194   1.00 48.41 ? 48  GLN   A C   1 
ATOM   224  O O   . GLN   A 1 48  ? -4.526  -16.776 3.233   1.00 52.84 ? 48  GLN   A O   1 
ATOM   225  C CB  . GLN   A 1 48  ? -4.382  -13.689 2.447   1.00 49.74 ? 48  GLN   A CB  1 
ATOM   226  C CG  . GLN   A 1 48  ? -5.132  -13.680 3.768   1.00 54.04 ? 48  GLN   A CG  1 
ATOM   227  C CD  . GLN   A 1 48  ? -6.627  -13.859 3.595   1.00 57.76 ? 48  GLN   A CD  1 
ATOM   228  O OE1 . GLN   A 1 48  ? -7.258  -13.171 2.795   1.00 57.96 ? 48  GLN   A OE1 1 
ATOM   229  N NE2 . GLN   A 1 48  ? -7.203  -14.781 4.353   1.00 56.46 ? 48  GLN   A NE2 1 
ATOM   230  N N   . ARG   A 1 49  ? -4.604  -16.611 0.989   1.00 50.12 ? 49  ARG   A N   1 
ATOM   231  C CA  . ARG   A 1 49  ? -5.516  -17.736 0.831   1.00 49.27 ? 49  ARG   A CA  1 
ATOM   232  C C   . ARG   A 1 49  ? -4.890  -18.982 0.220   1.00 47.09 ? 49  ARG   A C   1 
ATOM   233  O O   . ARG   A 1 49  ? -5.482  -20.061 0.331   1.00 47.57 ? 49  ARG   A O   1 
ATOM   234  C CB  . ARG   A 1 49  ? -6.721  -17.327 -0.033  1.00 49.17 ? 49  ARG   A CB  1 
ATOM   235  C CG  . ARG   A 1 49  ? -7.940  -16.887 0.760   1.00 51.70 ? 49  ARG   A CG  1 
ATOM   236  C CD  . ARG   A 1 49  ? -8.271  -15.420 0.520   1.00 54.52 ? 49  ARG   A CD  1 
ATOM   237  N NE  . ARG   A 1 49  ? -9.303  -15.241 -0.495  1.00 51.08 ? 49  ARG   A NE  1 
ATOM   238  C CZ  . ARG   A 1 49  ? -9.871  -14.078 -0.786  1.00 52.51 ? 49  ARG   A CZ  1 
ATOM   239  N NH1 . ARG   A 1 49  ? -9.526  -12.964 -0.161  1.00 53.45 ? 49  ARG   A NH1 1 
ATOM   240  N NH2 . ARG   A 1 49  ? -10.814 -14.033 -1.723  1.00 52.56 ? 49  ARG   A NH2 1 
ATOM   241  N N   . ASP   A 1 50  ? -3.722  -18.875 -0.415  1.00 46.41 ? 50  ASP   A N   1 
ATOM   242  C CA  . ASP   A 1 50  ? -3.160  -20.021 -1.122  1.00 46.18 ? 50  ASP   A CA  1 
ATOM   243  C C   . ASP   A 1 50  ? -2.487  -21.031 -0.203  1.00 47.15 ? 50  ASP   A C   1 
ATOM   244  O O   . ASP   A 1 50  ? -2.101  -22.106 -0.677  1.00 47.83 ? 50  ASP   A O   1 
ATOM   245  C CB  . ASP   A 1 50  ? -2.151  -19.561 -2.178  1.00 48.42 ? 50  ASP   A CB  1 
ATOM   246  C CG  . ASP   A 1 50  ? -2.018  -20.546 -3.317  1.00 47.24 ? 50  ASP   A CG  1 
ATOM   247  O OD1 . ASP   A 1 50  ? -2.982  -21.302 -3.558  1.00 44.92 ? 50  ASP   A OD1 1 
ATOM   248  O OD2 . ASP   A 1 50  ? -0.954  -20.570 -3.969  1.00 47.84 ? 50  ASP   A OD2 1 
ATOM   249  N N   . GLY   A 1 51  ? -2.334  -20.716 1.082   1.00 50.00 ? 51  GLY   A N   1 
ATOM   250  C CA  . GLY   A 1 51  ? -1.693  -21.604 2.024   1.00 48.14 ? 51  GLY   A CA  1 
ATOM   251  C C   . GLY   A 1 51  ? -2.282  -23.001 2.036   1.00 49.90 ? 51  GLY   A C   1 
ATOM   252  O O   . GLY   A 1 51  ? -1.620  -23.980 1.674   1.00 50.22 ? 51  GLY   A O   1 
ATOM   253  N N   . PRO   A 1 52  ? -3.542  -23.124 2.462   1.00 45.30 ? 52  PRO   A N   1 
ATOM   254  C CA  . PRO   A 1 52  ? -4.196  -24.439 2.490   1.00 44.60 ? 52  PRO   A CA  1 
ATOM   255  C C   . PRO   A 1 52  ? -4.777  -24.888 1.157   1.00 44.31 ? 52  PRO   A C   1 
ATOM   256  O O   . PRO   A 1 52  ? -5.383  -25.964 1.102   1.00 40.53 ? 52  PRO   A O   1 
ATOM   257  C CB  . PRO   A 1 52  ? -5.309  -24.236 3.527   1.00 48.51 ? 52  PRO   A CB  1 
ATOM   258  C CG  . PRO   A 1 52  ? -5.660  -22.790 3.393   1.00 49.10 ? 52  PRO   A CG  1 
ATOM   259  C CD  . PRO   A 1 52  ? -4.359  -22.086 3.115   1.00 47.84 ? 52  PRO   A CD  1 
ATOM   260  N N   . ILE   A 1 53  ? -4.612  -24.112 0.088   1.00 45.53 ? 53  ILE   A N   1 
ATOM   261  C CA  . ILE   A 1 53  ? -5.161  -24.445 -1.217  1.00 43.11 ? 53  ILE   A CA  1 
ATOM   262  C C   . ILE   A 1 53  ? -4.069  -24.836 -2.205  1.00 43.82 ? 53  ILE   A C   1 
ATOM   263  O O   . ILE   A 1 53  ? -4.212  -25.823 -2.931  1.00 40.36 ? 53  ILE   A O   1 
ATOM   264  C CB  . ILE   A 1 53  ? -6.012  -23.276 -1.762  1.00 43.53 ? 53  ILE   A CB  1 
ATOM   265  C CG1 . ILE   A 1 53  ? -7.207  -23.021 -0.840  1.00 41.84 ? 53  ILE   A CG1 1 
ATOM   266  C CG2 . ILE   A 1 53  ? -6.474  -23.561 -3.182  1.00 38.98 ? 53  ILE   A CG2 1 
ATOM   267  C CD1 . ILE   A 1 53  ? -8.009  -21.788 -1.194  1.00 45.95 ? 53  ILE   A CD1 1 
ATOM   268  N N   . ASN   A 1 54  ? -2.971  -24.077 -2.245  1.00 45.35 ? 54  ASN   A N   1 
ATOM   269  C CA  . ASN   A 1 54  ? -1.795  -24.397 -3.057  1.00 42.62 ? 54  ASN   A CA  1 
ATOM   270  C C   . ASN   A 1 54  ? -2.160  -24.501 -4.540  1.00 44.01 ? 54  ASN   A C   1 
ATOM   271  O O   . ASN   A 1 54  ? -1.966  -25.531 -5.186  1.00 41.74 ? 54  ASN   A O   1 
ATOM   272  C CB  . ASN   A 1 54  ? -1.124  -25.683 -2.555  1.00 39.18 ? 54  ASN   A CB  1 
ATOM   273  C CG  . ASN   A 1 54  ? 0.254   -25.905 -3.159  1.00 41.67 ? 54  ASN   A CG  1 
ATOM   274  O OD1 . ASN   A 1 54  ? 0.971   -24.954 -3.473  1.00 43.93 ? 54  ASN   A OD1 1 
ATOM   275  N ND2 . ASN   A 1 54  ? 0.630   -27.168 -3.321  1.00 41.77 ? 54  ASN   A ND2 1 
ATOM   276  N N   . ALA   A 1 55  ? -2.701  -23.406 -5.072  1.00 44.67 ? 55  ALA   A N   1 
ATOM   277  C CA  . ALA   A 1 55  ? -3.114  -23.344 -6.469  1.00 38.19 ? 55  ALA   A CA  1 
ATOM   278  C C   . ALA   A 1 55  ? -2.164  -22.531 -7.336  1.00 40.79 ? 55  ALA   A C   1 
ATOM   279  O O   . ALA   A 1 55  ? -1.881  -22.923 -8.472  1.00 40.87 ? 55  ALA   A O   1 
ATOM   280  C CB  . ALA   A 1 55  ? -4.528  -22.764 -6.579  1.00 38.87 ? 55  ALA   A CB  1 
ATOM   281  N N   . VAL   A 1 56  ? -1.662  -21.409 -6.824  1.00 42.39 ? 56  VAL   A N   1 
ATOM   282  C CA  . VAL   A 1 56  ? -0.748  -20.543 -7.570  1.00 39.99 ? 56  VAL   A CA  1 
ATOM   283  C C   . VAL   A 1 56  ? 0.663   -21.005 -7.217  1.00 43.68 ? 56  VAL   A C   1 
ATOM   284  O O   . VAL   A 1 56  ? 1.287   -20.516 -6.275  1.00 43.26 ? 56  VAL   A O   1 
ATOM   285  C CB  . VAL   A 1 56  ? -0.976  -19.068 -7.253  1.00 40.45 ? 56  VAL   A CB  1 
ATOM   286  C CG1 . VAL   A 1 56  ? -0.090  -18.189 -8.119  1.00 41.43 ? 56  VAL   A CG1 1 
ATOM   287  C CG2 . VAL   A 1 56  ? -2.446  -18.712 -7.435  1.00 37.17 ? 56  VAL   A CG2 1 
ATOM   288  N N   . VAL   A 1 57  ? 1.174   -21.961 -7.993  1.00 42.18 ? 57  VAL   A N   1 
ATOM   289  C CA  . VAL   A 1 57  ? 2.440   -22.608 -7.663  1.00 39.93 ? 57  VAL   A CA  1 
ATOM   290  C C   . VAL   A 1 57  ? 3.648   -21.943 -8.317  1.00 40.12 ? 57  VAL   A C   1 
ATOM   291  O O   . VAL   A 1 57  ? 4.780   -22.141 -7.852  1.00 39.68 ? 57  VAL   A O   1 
ATOM   292  C CB  . VAL   A 1 57  ? 2.379   -24.095 -8.045  1.00 40.00 ? 57  VAL   A CB  1 
ATOM   293  C CG1 . VAL   A 1 57  ? 1.318   -24.800 -7.214  1.00 39.80 ? 57  VAL   A CG1 1 
ATOM   294  C CG2 . VAL   A 1 57  ? 2.086   -24.246 -9.531  1.00 42.09 ? 57  VAL   A CG2 1 
ATOM   295  N N   . VAL   A 1 58  ? 3.445   -21.178 -9.385  1.00 41.17 ? 58  VAL   A N   1 
ATOM   296  C CA  . VAL   A 1 58  ? 4.492   -20.368 -9.994  1.00 41.05 ? 58  VAL   A CA  1 
ATOM   297  C C   . VAL   A 1 58  ? 4.085   -18.913 -9.844  1.00 43.45 ? 58  VAL   A C   1 
ATOM   298  O O   . VAL   A 1 58  ? 2.950   -18.548 -10.173 1.00 45.02 ? 58  VAL   A O   1 
ATOM   299  C CB  . VAL   A 1 58  ? 4.718   -20.733 -11.472 1.00 42.92 ? 58  VAL   A CB  1 
ATOM   300  C CG1 . VAL   A 1 58  ? 5.662   -19.730 -12.128 1.00 42.08 ? 58  VAL   A CG1 1 
ATOM   301  C CG2 . VAL   A 1 58  ? 5.277   -22.140 -11.587 1.00 40.72 ? 58  VAL   A CG2 1 
ATOM   302  N N   . ARG   A 1 59  ? 5.000   -18.088 -9.336  1.00 43.52 ? 59  ARG   A N   1 
ATOM   303  C CA  . ARG   A 1 59  ? 4.692   -16.706 -8.995  1.00 46.27 ? 59  ARG   A CA  1 
ATOM   304  C C   . ARG   A 1 59  ? 5.709   -15.772 -9.631  1.00 46.89 ? 59  ARG   A C   1 
ATOM   305  O O   . ARG   A 1 59  ? 6.918   -16.018 -9.564  1.00 47.16 ? 59  ARG   A O   1 
ATOM   306  C CB  . ARG   A 1 59  ? 4.650   -16.522 -7.473  1.00 45.37 ? 59  ARG   A CB  1 
ATOM   307  C CG  . ARG   A 1 59  ? 3.683   -17.491 -6.799  1.00 45.40 ? 59  ARG   A CG  1 
ATOM   308  C CD  . ARG   A 1 59  ? 3.430   -17.181 -5.334  1.00 42.85 ? 59  ARG   A CD  1 
ATOM   309  N NE  . ARG   A 1 59  ? 2.430   -18.093 -4.788  1.00 45.70 ? 59  ARG   A NE  1 
ATOM   310  C CZ  . ARG   A 1 59  ? 1.955   -18.047 -3.550  1.00 45.87 ? 59  ARG   A CZ  1 
ATOM   311  N NH1 . ARG   A 1 59  ? 2.368   -17.137 -2.681  1.00 47.43 ? 59  ARG   A NH1 1 
ATOM   312  N NH2 . ARG   A 1 59  ? 1.041   -18.936 -3.172  1.00 47.17 ? 59  ARG   A NH2 1 
ATOM   313  N N   . ASP   A 1 60  ? 5.208   -14.705 -10.244 1.00 47.82 ? 60  ASP   A N   1 
ATOM   314  C CA  . ASP   A 1 60  ? 5.990   -13.730 -10.994 1.00 52.21 ? 60  ASP   A CA  1 
ATOM   315  C C   . ASP   A 1 60  ? 5.644   -12.325 -10.525 1.00 50.68 ? 60  ASP   A C   1 
ATOM   316  O O   . ASP   A 1 60  ? 5.342   -11.429 -11.314 1.00 51.04 ? 60  ASP   A O   1 
ATOM   317  C CB  . ASP   A 1 60  ? 5.729   -13.898 -12.490 1.00 47.49 ? 60  ASP   A CB  1 
ATOM   318  C CG  . ASP   A 1 60  ? 6.834   -13.321 -13.352 1.00 52.27 ? 60  ASP   A CG  1 
ATOM   319  O OD1 . ASP   A 1 60  ? 7.814   -12.793 -12.793 1.00 54.33 ? 60  ASP   A OD1 1 
ATOM   320  O OD2 . ASP   A 1 60  ? 6.720   -13.402 -14.592 1.00 53.43 ? 60  ASP   A OD2 1 
ATOM   321  N N   . PHE   A 1 61  ? 5.689   -12.122 -9.207  1.00 48.27 ? 61  PHE   A N   1 
ATOM   322  C CA  . PHE   A 1 61  ? 5.071   -10.939 -8.615  1.00 46.94 ? 61  PHE   A CA  1 
ATOM   323  C C   . PHE   A 1 61  ? 5.859   -9.671  -8.917  1.00 47.94 ? 61  PHE   A C   1 
ATOM   324  O O   . PHE   A 1 61  ? 5.265   -8.607  -9.130  1.00 50.17 ? 61  PHE   A O   1 
ATOM   325  C CB  . PHE   A 1 61  ? 4.918   -11.126 -7.106  1.00 51.04 ? 61  PHE   A CB  1 
ATOM   326  C CG  . PHE   A 1 61  ? 3.875   -12.135 -6.723  1.00 49.67 ? 61  PHE   A CG  1 
ATOM   327  C CD1 . PHE   A 1 61  ? 3.039   -12.691 -7.680  1.00 48.01 ? 61  PHE   A CD1 1 
ATOM   328  C CD2 . PHE   A 1 61  ? 3.720   -12.519 -5.403  1.00 46.00 ? 61  PHE   A CD2 1 
ATOM   329  C CE1 . PHE   A 1 61  ? 2.077   -13.619 -7.329  1.00 48.16 ? 61  PHE   A CE1 1 
ATOM   330  C CE2 . PHE   A 1 61  ? 2.757   -13.445 -5.043  1.00 45.99 ? 61  PHE   A CE2 1 
ATOM   331  C CZ  . PHE   A 1 61  ? 1.934   -13.994 -6.008  1.00 48.28 ? 61  PHE   A CZ  1 
ATOM   332  N N   . ASP   A 1 62  ? 7.191   -9.756  -8.932  1.00 49.70 ? 62  ASP   A N   1 
ATOM   333  C CA  . ASP   A 1 62  ? 7.999   -8.565  -9.177  1.00 53.07 ? 62  ASP   A CA  1 
ATOM   334  C C   . ASP   A 1 62  ? 7.766   -8.021  -10.580 1.00 53.29 ? 62  ASP   A C   1 
ATOM   335  O O   . ASP   A 1 62  ? 7.503   -6.826  -10.761 1.00 53.93 ? 62  ASP   A O   1 
ATOM   336  C CB  . ASP   A 1 62  ? 9.477   -8.877  -8.965  1.00 53.84 ? 62  ASP   A CB  1 
ATOM   337  C CG  . ASP   A 1 62  ? 9.809   -9.157  -7.515  1.00 62.71 ? 62  ASP   A CG  1 
ATOM   338  O OD1 . ASP   A 1 62  ? 9.073   -8.671  -6.633  1.00 65.71 ? 62  ASP   A OD1 1 
ATOM   339  O OD2 . ASP   A 1 62  ? 10.810  -9.857  -7.261  1.00 66.06 ? 62  ASP   A OD2 1 
ATOM   340  N N   . ARG   A 1 63  ? 7.863   -8.889  -11.590 1.00 49.69 ? 63  ARG   A N   1 
ATOM   341  C CA  . ARG   A 1 63  ? 7.639   -8.450  -12.963 1.00 53.18 ? 63  ARG   A CA  1 
ATOM   342  C C   . ARG   A 1 63  ? 6.182   -8.081  -13.205 1.00 52.48 ? 63  ARG   A C   1 
ATOM   343  O O   . ARG   A 1 63  ? 5.894   -7.244  -14.068 1.00 49.98 ? 63  ARG   A O   1 
ATOM   344  C CB  . ARG   A 1 63  ? 8.080   -9.535  -13.947 1.00 48.77 ? 63  ARG   A CB  1 
ATOM   345  C CG  . ARG   A 1 63  ? 9.562   -9.870  -13.890 1.00 49.72 ? 63  ARG   A CG  1 
ATOM   346  C CD  . ARG   A 1 63  ? 9.978   -10.693 -15.098 1.00 48.70 ? 63  ARG   A CD  1 
ATOM   347  N NE  . ARG   A 1 63  ? 9.203   -11.921 -15.221 1.00 51.15 ? 63  ARG   A NE  1 
ATOM   348  C CZ  . ARG   A 1 63  ? 9.251   -12.735 -16.266 1.00 50.88 ? 63  ARG   A CZ  1 
ATOM   349  N NH1 . ARG   A 1 63  ? 10.018  -12.472 -17.311 1.00 45.63 ? 63  ARG   A NH1 1 
ATOM   350  N NH2 . ARG   A 1 63  ? 8.508   -13.838 -16.265 1.00 48.16 ? 63  ARG   A NH2 1 
ATOM   351  N N   . ALA   A 1 64  ? 5.253   -8.685  -12.460 1.00 51.93 ? 64  ALA   A N   1 
ATOM   352  C CA  . ALA   A 1 64  ? 3.846   -8.343  -12.630 1.00 49.82 ? 64  ALA   A CA  1 
ATOM   353  C C   . ALA   A 1 64  ? 3.557   -6.927  -12.145 1.00 52.49 ? 64  ALA   A C   1 
ATOM   354  O O   . ALA   A 1 64  ? 2.732   -6.223  -12.735 1.00 50.44 ? 64  ALA   A O   1 
ATOM   355  C CB  . ALA   A 1 64  ? 2.960   -9.351  -11.901 1.00 49.68 ? 64  ALA   A CB  1 
ATOM   356  N N   . ARG   A 1 65  ? 4.219   -6.494  -11.068 1.00 53.45 ? 65  ARG   A N   1 
ATOM   357  C CA  . ARG   A 1 65  ? 4.040   -5.122  -10.602 1.00 50.98 ? 65  ARG   A CA  1 
ATOM   358  C C   . ARG   A 1 65  ? 4.551   -4.122  -11.629 1.00 53.34 ? 65  ARG   A C   1 
ATOM   359  O O   . ARG   A 1 65  ? 3.990   -3.030  -11.777 1.00 56.84 ? 65  ARG   A O   1 
ATOM   360  C CB  . ARG   A 1 65  ? 4.743   -4.919  -9.259  1.00 51.44 ? 65  ARG   A CB  1 
ATOM   361  C CG  . ARG   A 1 65  ? 4.009   -5.532  -8.077  1.00 49.83 ? 65  ARG   A CG  1 
ATOM   362  C CD  . ARG   A 1 65  ? 4.730   -5.251  -6.768  1.00 52.71 ? 65  ARG   A CD  1 
ATOM   363  N NE  . ARG   A 1 65  ? 4.060   -4.238  -5.959  1.00 52.60 ? 65  ARG   A NE  1 
ATOM   364  C CZ  . ARG   A 1 65  ? 4.395   -2.956  -5.924  1.00 52.24 ? 65  ARG   A CZ  1 
ATOM   365  N NH1 . ARG   A 1 65  ? 5.390   -2.481  -6.655  1.00 55.65 ? 65  ARG   A NH1 1 
ATOM   366  N NH2 . ARG   A 1 65  ? 3.716   -2.129  -5.134  1.00 45.96 ? 65  ARG   A NH2 1 
ATOM   367  N N   . ASP   A 1 66  ? 5.620   -4.476  -12.348 1.00 53.66 ? 66  ASP   A N   1 
ATOM   368  C CA  . ASP   A 1 66  ? 6.120   -3.607  -13.408 1.00 54.23 ? 66  ASP   A CA  1 
ATOM   369  C C   . ASP   A 1 66  ? 5.118   -3.494  -14.549 1.00 53.11 ? 66  ASP   A C   1 
ATOM   370  O O   . ASP   A 1 66  ? 4.899   -2.400  -15.084 1.00 55.22 ? 66  ASP   A O   1 
ATOM   371  C CB  . ASP   A 1 66  ? 7.465   -4.125  -13.921 1.00 53.18 ? 66  ASP   A CB  1 
ATOM   372  C CG  . ASP   A 1 66  ? 8.612   -3.785  -12.991 1.00 60.53 ? 66  ASP   A CG  1 
ATOM   373  O OD1 . ASP   A 1 66  ? 8.609   -2.666  -12.437 1.00 64.33 ? 66  ASP   A OD1 1 
ATOM   374  O OD2 . ASP   A 1 66  ? 9.516   -4.629  -12.811 1.00 63.41 ? 66  ASP   A OD2 1 
ATOM   375  N N   . ALA   A 1 67  ? 4.496   -4.612  -14.933 1.00 52.18 ? 67  ALA   A N   1 
ATOM   376  C CA  . ALA   A 1 67  ? 3.519   -4.579  -16.016 1.00 52.86 ? 67  ALA   A CA  1 
ATOM   377  C C   . ALA   A 1 67  ? 2.267   -3.814  -15.607 1.00 51.41 ? 67  ALA   A C   1 
ATOM   378  O O   . ALA   A 1 67  ? 1.658   -3.120  -16.430 1.00 54.44 ? 67  ALA   A O   1 
ATOM   379  C CB  . ALA   A 1 67  ? 3.164   -6.002  -16.446 1.00 48.70 ? 67  ALA   A CB  1 
ATOM   380  N N   . ALA   A 1 68  ? 1.864   -3.934  -14.339 1.00 49.30 ? 68  ALA   A N   1 
ATOM   381  C CA  . ALA   A 1 68  ? 0.731   -3.158  -13.848 1.00 51.36 ? 68  ALA   A CA  1 
ATOM   382  C C   . ALA   A 1 68  ? 1.054   -1.669  -13.821 1.00 53.85 ? 68  ALA   A C   1 
ATOM   383  O O   . ALA   A 1 68  ? 0.182   -0.836  -14.091 1.00 51.43 ? 68  ALA   A O   1 
ATOM   384  C CB  . ALA   A 1 68  ? 0.321   -3.645  -12.459 1.00 50.01 ? 68  ALA   A CB  1 
ATOM   385  N N   . LYS   A 1 69  ? 2.298   -1.314  -13.488 1.00 53.07 ? 69  LYS   A N   1 
ATOM   386  C CA  . LYS   A 1 69  ? 2.717   0.081   -13.589 1.00 55.62 ? 69  LYS   A CA  1 
ATOM   387  C C   . LYS   A 1 69  ? 2.701   0.552   -15.037 1.00 50.78 ? 69  LYS   A C   1 
ATOM   388  O O   . LYS   A 1 69  ? 2.349   1.703   -15.321 1.00 53.43 ? 69  LYS   A O   1 
ATOM   389  C CB  . LYS   A 1 69  ? 4.108   0.265   -12.979 1.00 53.83 ? 69  LYS   A CB  1 
ATOM   390  C CG  . LYS   A 1 69  ? 4.110   0.571   -11.491 1.00 55.07 ? 69  LYS   A CG  1 
ATOM   391  C CD  . LYS   A 1 69  ? 5.485   1.036   -11.026 1.00 56.74 ? 69  LYS   A CD  1 
ATOM   392  C CE  . LYS   A 1 69  ? 6.369   -0.130  -10.612 1.00 59.37 ? 69  LYS   A CE  1 
ATOM   393  N NZ  . LYS   A 1 69  ? 6.006   -0.642  -9.261  1.00 59.00 ? 69  LYS   A NZ  1 
ATOM   394  N N   . ALA   A 1 70  ? 3.081   -0.327  -15.970 1.00 51.87 ? 70  ALA   A N   1 
ATOM   395  C CA  . ALA   A 1 70  ? 3.005   0.021   -17.384 1.00 51.27 ? 70  ALA   A CA  1 
ATOM   396  C C   . ALA   A 1 70  ? 1.560   0.167   -17.844 1.00 49.64 ? 70  ALA   A C   1 
ATOM   397  O O   . ALA   A 1 70  ? 1.271   0.976   -18.735 1.00 52.75 ? 70  ALA   A O   1 
ATOM   398  C CB  . ALA   A 1 70  ? 3.728   -1.031  -18.225 1.00 46.51 ? 70  ALA   A CB  1 
ATOM   399  N N   . ALA   A 1 71  ? 0.642   -0.598  -17.249 1.00 51.03 ? 71  ALA   A N   1 
ATOM   400  C CA  . ALA   A 1 71  ? -0.769  -0.470  -17.599 1.00 51.96 ? 71  ALA   A CA  1 
ATOM   401  C C   . ALA   A 1 71  ? -1.346  0.844   -17.091 1.00 53.72 ? 71  ALA   A C   1 
ATOM   402  O O   . ALA   A 1 71  ? -2.153  1.481   -17.779 1.00 54.78 ? 71  ALA   A O   1 
ATOM   403  C CB  . ALA   A 1 71  ? -1.555  -1.655  -17.041 1.00 47.95 ? 71  ALA   A CB  1 
ATOM   404  N N   . ASP   A 1 72  ? -0.950  1.261   -15.884 1.00 55.30 ? 72  ASP   A N   1 
ATOM   405  C CA  . ASP   A 1 72  ? -1.378  2.559   -15.372 1.00 54.42 ? 72  ASP   A CA  1 
ATOM   406  C C   . ASP   A 1 72  ? -0.853  3.697   -16.238 1.00 54.38 ? 72  ASP   A C   1 
ATOM   407  O O   . ASP   A 1 72  ? -1.532  4.715   -16.416 1.00 54.55 ? 72  ASP   A O   1 
ATOM   408  C CB  . ASP   A 1 72  ? -0.917  2.732   -13.924 1.00 54.39 ? 72  ASP   A CB  1 
ATOM   409  C CG  . ASP   A 1 72  ? -1.900  2.155   -12.926 1.00 56.38 ? 72  ASP   A CG  1 
ATOM   410  O OD1 . ASP   A 1 72  ? -3.110  2.128   -13.234 1.00 57.82 ? 72  ASP   A OD1 1 
ATOM   411  O OD2 . ASP   A 1 72  ? -1.465  1.737   -11.833 1.00 57.73 ? 72  ASP   A OD2 1 
ATOM   412  N N   . ALA   A 1 73  ? 0.358   3.544   -16.781 1.00 52.83 ? 73  ALA   A N   1 
ATOM   413  C CA  . ALA   A 1 73  ? 0.884   4.548   -17.700 1.00 52.93 ? 73  ALA   A CA  1 
ATOM   414  C C   . ALA   A 1 73  ? 0.089   4.587   -18.997 1.00 55.57 ? 73  ALA   A C   1 
ATOM   415  O O   . ALA   A 1 73  ? -0.046  5.652   -19.609 1.00 55.35 ? 73  ALA   A O   1 
ATOM   416  C CB  . ALA   A 1 73  ? 2.362   4.280   -17.985 1.00 50.71 ? 73  ALA   A CB  1 
ATOM   417  N N   . GLU   A 1 74  ? -0.445  3.443   -19.432 1.00 55.28 ? 74  GLU   A N   1 
ATOM   418  C CA  . GLU   A 1 74  ? -1.299  3.436   -20.614 1.00 54.99 ? 74  GLU   A CA  1 
ATOM   419  C C   . GLU   A 1 74  ? -2.663  4.040   -20.308 1.00 54.48 ? 74  GLU   A C   1 
ATOM   420  O O   . GLU   A 1 74  ? -3.191  4.828   -21.102 1.00 57.93 ? 74  GLU   A O   1 
ATOM   421  C CB  . GLU   A 1 74  ? -1.442  2.013   -21.150 1.00 55.75 ? 74  GLU   A CB  1 
ATOM   422  C CG  . GLU   A 1 74  ? -0.211  1.501   -21.881 1.00 53.66 ? 74  GLU   A CG  1 
ATOM   423  C CD  . GLU   A 1 74  ? -0.405  0.106   -22.444 1.00 57.76 ? 74  GLU   A CD  1 
ATOM   424  O OE1 . GLU   A 1 74  ? -0.782  -0.799  -21.671 1.00 59.11 ? 74  GLU   A OE1 1 
ATOM   425  O OE2 . GLU   A 1 74  ? -0.193  -0.083  -23.661 1.00 62.48 ? 74  GLU   A OE2 1 
ATOM   426  N N   . ILE   A 1 75  ? -3.243  3.685   -19.159 1.00 54.30 ? 75  ILE   A N   1 
ATOM   427  C CA  . ILE   A 1 75  ? -4.503  4.286   -18.730 1.00 54.77 ? 75  ILE   A CA  1 
ATOM   428  C C   . ILE   A 1 75  ? -4.375  5.803   -18.672 1.00 55.82 ? 75  ILE   A C   1 
ATOM   429  O O   . ILE   A 1 75  ? -5.290  6.535   -19.068 1.00 54.23 ? 75  ILE   A O   1 
ATOM   430  C CB  . ILE   A 1 75  ? -4.934  3.701   -17.371 1.00 54.82 ? 75  ILE   A CB  1 
ATOM   431  C CG1 . ILE   A 1 75  ? -5.476  2.281   -17.542 1.00 51.52 ? 75  ILE   A CG1 1 
ATOM   432  C CG2 . ILE   A 1 75  ? -5.981  4.583   -16.704 1.00 48.74 ? 75  ILE   A CG2 1 
ATOM   433  C CD1 . ILE   A 1 75  ? -6.890  2.236   -18.075 1.00 49.02 ? 75  ILE   A CD1 1 
ATOM   434  N N   . ALA   A 1 76  ? -3.233  6.301   -18.192 1.00 55.56 ? 76  ALA   A N   1 
ATOM   435  C CA  . ALA   A 1 76  ? -3.038  7.744   -18.099 1.00 54.03 ? 76  ALA   A CA  1 
ATOM   436  C C   . ALA   A 1 76  ? -3.009  8.388   -19.479 1.00 54.66 ? 76  ALA   A C   1 
ATOM   437  O O   . ALA   A 1 76  ? -3.495  9.510   -19.658 1.00 57.04 ? 76  ALA   A O   1 
ATOM   438  C CB  . ALA   A 1 76  ? -1.751  8.055   -17.333 1.00 51.06 ? 76  ALA   A CB  1 
ATOM   439  N N   . ALA   A 1 77  ? -2.448  7.691   -20.468 1.00 52.64 ? 77  ALA   A N   1 
ATOM   440  C CA  . ALA   A 1 77  ? -2.381  8.183   -21.839 1.00 54.05 ? 77  ALA   A CA  1 
ATOM   441  C C   . ALA   A 1 77  ? -3.684  7.996   -22.601 1.00 55.49 ? 77  ALA   A C   1 
ATOM   442  O O   . ALA   A 1 77  ? -3.668  7.985   -23.839 1.00 53.08 ? 77  ALA   A O   1 
ATOM   443  C CB  . ALA   A 1 77  ? -1.232  7.503   -22.585 1.00 51.05 ? 77  ALA   A CB  1 
ATOM   444  N N   . ALA   A 1 78  ? -4.802  7.849   -21.886 1.00 57.15 ? 78  ALA   A N   1 
ATOM   445  C CA  . ALA   A 1 78  ? -6.137  7.663   -22.449 1.00 55.39 ? 78  ALA   A CA  1 
ATOM   446  C C   . ALA   A 1 78  ? -6.271  6.374   -23.251 1.00 53.27 ? 78  ALA   A C   1 
ATOM   447  O O   . ALA   A 1 78  ? -7.222  6.221   -24.022 1.00 52.55 ? 78  ALA   A O   1 
ATOM   448  C CB  . ALA   A 1 78  ? -6.558  8.856   -23.312 1.00 54.49 ? 78  ALA   A CB  1 
ATOM   449  N N   . VAL   A 1 79  ? -5.345  5.433   -23.076 1.00 54.29 ? 79  VAL   A N   1 
ATOM   450  C CA  . VAL   A 1 79  ? -5.426  4.134   -23.737 1.00 53.94 ? 79  VAL   A CA  1 
ATOM   451  C C   . VAL   A 1 79  ? -6.438  3.265   -23.005 1.00 51.48 ? 79  VAL   A C   1 
ATOM   452  O O   . VAL   A 1 79  ? -6.484  3.238   -21.768 1.00 52.67 ? 79  VAL   A O   1 
ATOM   453  C CB  . VAL   A 1 79  ? -4.042  3.456   -23.789 1.00 54.77 ? 79  VAL   A CB  1 
ATOM   454  C CG1 . VAL   A 1 79  ? -4.121  2.123   -24.514 1.00 50.87 ? 79  VAL   A CG1 1 
ATOM   455  C CG2 . VAL   A 1 79  ? -3.026  4.382   -24.450 1.00 53.87 ? 79  VAL   A CG2 1 
ATOM   456  N N   . ARG   A 1 80  ? -7.252  2.540   -23.769 1.00 47.52 ? 80  ARG   A N   1 
ATOM   457  C CA  . ARG   A 1 80  ? -8.224  1.608   -23.210 1.00 49.36 ? 80  ARG   A CA  1 
ATOM   458  C C   . ARG   A 1 80  ? -8.168  0.300   -23.983 1.00 52.59 ? 80  ARG   A C   1 
ATOM   459  O O   . ARG   A 1 80  ? -8.287  0.295   -25.213 1.00 55.29 ? 80  ARG   A O   1 
ATOM   460  C CB  . ARG   A 1 80  ? -9.642  2.189   -23.256 1.00 48.43 ? 80  ARG   A CB  1 
ATOM   461  C CG  . ARG   A 1 80  ? -9.860  3.395   -22.354 1.00 50.50 ? 80  ARG   A CG  1 
ATOM   462  C CD  . ARG   A 1 80  ? -9.603  3.052   -20.896 1.00 52.17 ? 80  ARG   A CD  1 
ATOM   463  N NE  . ARG   A 1 80  ? -9.850  4.189   -20.017 1.00 52.50 ? 80  ARG   A NE  1 
ATOM   464  C CZ  . ARG   A 1 80  ? -8.961  5.134   -19.745 1.00 52.56 ? 80  ARG   A CZ  1 
ATOM   465  N NH1 . ARG   A 1 80  ? -7.747  5.110   -20.267 1.00 52.62 ? 80  ARG   A NH1 1 
ATOM   466  N NH2 . ARG   A 1 80  ? -9.302  6.130   -18.931 1.00 48.23 ? 80  ARG   A NH2 1 
ATOM   467  N N   . LYS   A 1 81  ? -7.985  -0.798  -23.259 1.00 50.74 ? 81  LYS   A N   1 
ATOM   468  C CA  . LYS   A 1 81  ? -7.996  -2.144  -23.802 1.00 48.20 ? 81  LYS   A CA  1 
ATOM   469  C C   . LYS   A 1 81  ? -8.924  -3.007  -22.960 1.00 49.23 ? 81  LYS   A C   1 
ATOM   470  O O   . LYS   A 1 81  ? -9.108  -2.742  -21.767 1.00 47.17 ? 81  LYS   A O   1 
ATOM   471  C CB  . LYS   A 1 81  ? -6.581  -2.743  -23.821 1.00 48.29 ? 81  LYS   A CB  1 
ATOM   472  C CG  . LYS   A 1 81  ? -5.607  -1.989  -24.717 1.00 48.79 ? 81  LYS   A CG  1 
ATOM   473  C CD  . LYS   A 1 81  ? -4.224  -2.616  -24.700 1.00 48.91 ? 81  LYS   A CD  1 
ATOM   474  C CE  . LYS   A 1 81  ? -3.253  -1.836  -25.572 1.00 51.50 ? 81  LYS   A CE  1 
ATOM   475  N NZ  . LYS   A 1 81  ? -1.898  -2.453  -25.572 1.00 57.02 ? 81  LYS   A NZ  1 
ATOM   476  N N   . PRO   A 1 82  ? -9.532  -4.037  -23.555 1.00 49.10 ? 82  PRO   A N   1 
ATOM   477  C CA  . PRO   A 1 82  ? -10.570 -4.797  -22.832 1.00 46.48 ? 82  PRO   A CA  1 
ATOM   478  C C   . PRO   A 1 82  ? -10.122 -5.380  -21.500 1.00 44.52 ? 82  PRO   A C   1 
ATOM   479  O O   . PRO   A 1 82  ? -10.950 -5.503  -20.588 1.00 44.27 ? 82  PRO   A O   1 
ATOM   480  C CB  . PRO   A 1 82  ? -10.951 -5.904  -23.830 1.00 45.78 ? 82  PRO   A CB  1 
ATOM   481  C CG  . PRO   A 1 82  ? -9.866  -5.911  -24.861 1.00 49.07 ? 82  PRO   A CG  1 
ATOM   482  C CD  . PRO   A 1 82  ? -9.385  -4.502  -24.943 1.00 46.29 ? 82  PRO   A CD  1 
ATOM   483  N N   . LEU   A 1 83  ? -8.847  -5.740  -21.350 1.00 46.33 ? 83  LEU   A N   1 
ATOM   484  C CA  . LEU   A 1 83  ? -8.340  -6.315  -20.108 1.00 48.52 ? 83  LEU   A CA  1 
ATOM   485  C C   . LEU   A 1 83  ? -7.189  -5.499  -19.531 1.00 50.41 ? 83  LEU   A C   1 
ATOM   486  O O   . LEU   A 1 83  ? -6.292  -6.052  -18.893 1.00 49.99 ? 83  LEU   A O   1 
ATOM   487  C CB  . LEU   A 1 83  ? -7.898  -7.761  -20.323 1.00 46.65 ? 83  LEU   A CB  1 
ATOM   488  C CG  . LEU   A 1 83  ? -8.981  -8.802  -20.593 1.00 44.92 ? 83  LEU   A CG  1 
ATOM   489  C CD1 . LEU   A 1 83  ? -8.355  -10.179 -20.712 1.00 44.48 ? 83  LEU   A CD1 1 
ATOM   490  C CD2 . LEU   A 1 83  ? -10.024 -8.779  -19.488 1.00 46.00 ? 83  LEU   A CD2 1 
ATOM   491  N N   . LEU   A 1 84  ? -7.208  -4.182  -19.734 1.00 48.59 ? 84  LEU   A N   1 
ATOM   492  C CA  . LEU   A 1 84  ? -6.085  -3.337  -19.343 1.00 48.96 ? 84  LEU   A CA  1 
ATOM   493  C C   . LEU   A 1 84  ? -5.878  -3.335  -17.832 1.00 48.44 ? 84  LEU   A C   1 
ATOM   494  O O   . LEU   A 1 84  ? -6.713  -2.819  -17.082 1.00 49.00 ? 84  LEU   A O   1 
ATOM   495  C CB  . LEU   A 1 84  ? -6.291  -1.909  -19.861 1.00 48.13 ? 84  LEU   A CB  1 
ATOM   496  C CG  . LEU   A 1 84  ? -5.067  -0.990  -19.830 1.00 48.35 ? 84  LEU   A CG  1 
ATOM   497  C CD1 . LEU   A 1 84  ? -3.841  -1.724  -20.340 1.00 47.38 ? 84  LEU   A CD1 1 
ATOM   498  C CD2 . LEU   A 1 84  ? -5.306  0.272   -20.654 1.00 49.04 ? 84  LEU   A CD2 1 
ATOM   499  N N   . GLY   A 1 85  ? -4.769  -3.917  -17.380 1.00 47.14 ? 85  GLY   A N   1 
ATOM   500  C CA  . GLY   A 1 85  ? -4.433  -3.939  -15.972 1.00 48.38 ? 85  GLY   A CA  1 
ATOM   501  C C   . GLY   A 1 85  ? -5.134  -4.998  -15.155 1.00 49.86 ? 85  GLY   A C   1 
ATOM   502  O O   . GLY   A 1 85  ? -5.060  -4.955  -13.921 1.00 49.77 ? 85  GLY   A O   1 
ATOM   503  N N   . VAL   A 1 86  ? -5.801  -5.952  -15.793 1.00 48.96 ? 86  VAL   A N   1 
ATOM   504  C CA  . VAL   A 1 86  ? -6.557  -6.984  -15.093 1.00 48.80 ? 86  VAL   A CA  1 
ATOM   505  C C   . VAL   A 1 86  ? -5.591  -8.094  -14.694 1.00 48.14 ? 86  VAL   A C   1 
ATOM   506  O O   . VAL   A 1 86  ? -4.977  -8.709  -15.581 1.00 47.04 ? 86  VAL   A O   1 
ATOM   507  C CB  . VAL   A 1 86  ? -7.696  -7.533  -15.959 1.00 48.03 ? 86  VAL   A CB  1 
ATOM   508  C CG1 . VAL   A 1 86  ? -8.437  -8.640  -15.221 1.00 47.31 ? 86  VAL   A CG1 1 
ATOM   509  C CG2 . VAL   A 1 86  ? -8.649  -6.416  -16.346 1.00 46.09 ? 86  VAL   A CG2 1 
ATOM   510  N N   . PRO   A 1 87  ? -5.430  -8.385  -13.405 1.00 49.44 ? 87  PRO   A N   1 
ATOM   511  C CA  . PRO   A 1 87  ? -4.516  -9.454  -12.998 1.00 50.52 ? 87  PRO   A CA  1 
ATOM   512  C C   . PRO   A 1 87  ? -5.138  -10.825 -13.209 1.00 48.55 ? 87  PRO   A C   1 
ATOM   513  O O   . PRO   A 1 87  ? -6.332  -11.033 -12.983 1.00 47.98 ? 87  PRO   A O   1 
ATOM   514  C CB  . PRO   A 1 87  ? -4.290  -9.170  -11.509 1.00 48.91 ? 87  PRO   A CB  1 
ATOM   515  C CG  . PRO   A 1 87  ? -5.567  -8.530  -11.067 1.00 48.73 ? 87  PRO   A CG  1 
ATOM   516  C CD  . PRO   A 1 87  ? -6.070  -7.732  -12.249 1.00 48.30 ? 87  PRO   A CD  1 
ATOM   517  N N   . MET   A 1 88  ? -4.308  -11.766 -13.649 1.00 43.14 ? 88  MET   A N   1 
ATOM   518  C CA  . MET   A 1 88  ? -4.759  -13.128 -13.879 1.00 45.63 ? 88  MET   A CA  1 
ATOM   519  C C   . MET   A 1 88  ? -3.561  -14.063 -13.820 1.00 45.86 ? 88  MET   A C   1 
ATOM   520  O O   . MET   A 1 88  ? -2.405  -13.634 -13.823 1.00 47.77 ? 88  MET   A O   1 
ATOM   521  C CB  . MET   A 1 88  ? -5.479  -13.268 -15.226 1.00 45.61 ? 88  MET   A CB  1 
ATOM   522  C CG  . MET   A 1 88  ? -4.586  -13.019 -16.432 1.00 45.26 ? 88  MET   A CG  1 
ATOM   523  S SD  . MET   A 1 88  ? -5.420  -13.247 -18.017 1.00 49.16 ? 88  MET   A SD  1 
ATOM   524  C CE  . MET   A 1 88  ? -5.860  -14.981 -17.932 1.00 44.18 ? 88  MET   A CE  1 
ATOM   525  N N   . THR   A 1 89  ? -3.862  -15.355 -13.760 1.00 43.19 ? 89  THR   A N   1 
ATOM   526  C CA  . THR   A 1 89  ? -2.890  -16.425 -13.898 1.00 45.16 ? 89  THR   A CA  1 
ATOM   527  C C   . THR   A 1 89  ? -3.314  -17.326 -15.051 1.00 43.66 ? 89  THR   A C   1 
ATOM   528  O O   . THR   A 1 89  ? -4.420  -17.213 -15.584 1.00 46.85 ? 89  THR   A O   1 
ATOM   529  C CB  . THR   A 1 89  ? -2.764  -17.241 -12.603 1.00 44.77 ? 89  THR   A CB  1 
ATOM   530  O OG1 . THR   A 1 89  ? -4.056  -17.722 -12.209 1.00 43.56 ? 89  THR   A OG1 1 
ATOM   531  C CG2 . THR   A 1 89  ? -2.182  -16.387 -11.486 1.00 46.50 ? 89  THR   A CG2 1 
ATOM   532  N N   . ILE   A 1 90  ? -2.416  -18.233 -15.438 1.00 44.29 ? 90  ILE   A N   1 
ATOM   533  C CA  . ILE   A 1 90  ? -2.690  -19.200 -16.492 1.00 44.96 ? 90  ILE   A CA  1 
ATOM   534  C C   . ILE   A 1 90  ? -2.130  -20.552 -16.070 1.00 44.45 ? 90  ILE   A C   1 
ATOM   535  O O   . ILE   A 1 90  ? -1.228  -20.645 -15.240 1.00 43.49 ? 90  ILE   A O   1 
ATOM   536  C CB  . ILE   A 1 90  ? -2.104  -18.768 -17.858 1.00 42.09 ? 90  ILE   A CB  1 
ATOM   537  C CG1 . ILE   A 1 90  ? -2.810  -19.504 -18.994 1.00 40.81 ? 90  ILE   A CG1 1 
ATOM   538  C CG2 . ILE   A 1 90  ? -0.614  -19.038 -17.904 1.00 42.16 ? 90  ILE   A CG2 1 
ATOM   539  C CD1 . ILE   A 1 90  ? -2.481  -18.976 -20.368 1.00 43.01 ? 90  ILE   A CD1 1 
ATOM   540  N N   . LYS   A 1 91  ? -2.695  -21.609 -16.646 1.00 42.91 ? 91  LYS   A N   1 
ATOM   541  C CA  . LYS   A 1 91  ? -2.265  -22.971 -16.351 1.00 39.30 ? 91  LYS   A CA  1 
ATOM   542  C C   . LYS   A 1 91  ? -0.761  -23.128 -16.556 1.00 40.93 ? 91  LYS   A C   1 
ATOM   543  O O   . LYS   A 1 91  ? -0.166  -22.512 -17.446 1.00 40.49 ? 91  LYS   A O   1 
ATOM   544  C CB  . LYS   A 1 91  ? -3.034  -23.948 -17.241 1.00 43.12 ? 91  LYS   A CB  1 
ATOM   545  C CG  . LYS   A 1 91  ? -2.903  -25.403 -16.871 1.00 39.77 ? 91  LYS   A CG  1 
ATOM   546  C CD  . LYS   A 1 91  ? -3.908  -26.202 -17.665 1.00 40.96 ? 91  LYS   A CD  1 
ATOM   547  C CE  . LYS   A 1 91  ? -3.681  -27.690 -17.547 1.00 41.27 ? 91  LYS   A CE  1 
ATOM   548  N NZ  . LYS   A 1 91  ? -4.669  -28.414 -18.385 1.00 44.33 ? 91  LYS   A NZ  1 
ATOM   549  N N   . GLU   A 1 92  ? -0.141  -23.969 -15.721 1.00 41.24 ? 92  GLU   A N   1 
ATOM   550  C CA  . GLU   A 1 92  ? 1.316   -24.070 -15.723 1.00 39.98 ? 92  GLU   A CA  1 
ATOM   551  C C   . GLU   A 1 92  ? 1.849   -24.620 -17.038 1.00 44.27 ? 92  GLU   A C   1 
ATOM   552  O O   . GLU   A 1 92  ? 2.999   -24.347 -17.402 1.00 42.71 ? 92  GLU   A O   1 
ATOM   553  C CB  . GLU   A 1 92  ? 1.794   -24.936 -14.557 1.00 40.95 ? 92  GLU   A CB  1 
ATOM   554  C CG  . GLU   A 1 92  ? 3.253   -24.727 -14.180 1.00 40.18 ? 92  GLU   A CG  1 
ATOM   555  C CD  . GLU   A 1 92  ? 4.179   -25.758 -14.795 1.00 42.68 ? 92  GLU   A CD  1 
ATOM   556  O OE1 . GLU   A 1 92  ? 3.710   -26.585 -15.604 1.00 41.61 ? 92  GLU   A OE1 1 
ATOM   557  O OE2 . GLU   A 1 92  ? 5.382   -25.744 -14.463 1.00 42.02 ? 92  GLU   A OE2 1 
ATOM   558  N N   . SER   A 1 93  ? 1.037   -25.387 -17.764 1.00 42.53 ? 93  SER   A N   1 
ATOM   559  C CA  . SER   A 1 93  ? 1.494   -25.960 -19.023 1.00 39.68 ? 93  SER   A CA  1 
ATOM   560  C C   . SER   A 1 93  ? 1.683   -24.906 -20.106 1.00 42.88 ? 93  SER   A C   1 
ATOM   561  O O   . SER   A 1 93  ? 2.404   -25.159 -21.078 1.00 41.30 ? 93  SER   A O   1 
ATOM   562  C CB  . SER   A 1 93  ? 0.513   -27.034 -19.494 1.00 39.74 ? 93  SER   A CB  1 
ATOM   563  O OG  . SER   A 1 93  ? -0.822  -26.666 -19.197 1.00 39.95 ? 93  SER   A OG  1 
ATOM   564  N N   . PHE   A 1 94  ? 1.063   -23.737 -19.964 1.00 43.76 ? 94  PHE   A N   1 
ATOM   565  C CA  . PHE   A 1 94  ? 1.286   -22.661 -20.918 1.00 41.70 ? 94  PHE   A CA  1 
ATOM   566  C C   . PHE   A 1 94  ? 2.646   -22.012 -20.691 1.00 44.22 ? 94  PHE   A C   1 
ATOM   567  O O   . PHE   A 1 94  ? 3.119   -21.896 -19.556 1.00 48.01 ? 94  PHE   A O   1 
ATOM   568  C CB  . PHE   A 1 94  ? 0.189   -21.605 -20.805 1.00 40.53 ? 94  PHE   A CB  1 
ATOM   569  C CG  . PHE   A 1 94  ? -1.131  -22.034 -21.372 1.00 43.52 ? 94  PHE   A CG  1 
ATOM   570  C CD1 . PHE   A 1 94  ? -1.423  -21.840 -22.715 1.00 43.26 ? 94  PHE   A CD1 1 
ATOM   571  C CD2 . PHE   A 1 94  ? -2.088  -22.621 -20.563 1.00 43.23 ? 94  PHE   A CD2 1 
ATOM   572  C CE1 . PHE   A 1 94  ? -2.643  -22.233 -23.239 1.00 41.12 ? 94  PHE   A CE1 1 
ATOM   573  C CE2 . PHE   A 1 94  ? -3.311  -23.016 -21.080 1.00 41.85 ? 94  PHE   A CE2 1 
ATOM   574  C CZ  . PHE   A 1 94  ? -3.588  -22.822 -22.420 1.00 43.20 ? 94  PHE   A CZ  1 
ATOM   575  N N   . ASP   A 1 95  ? 3.271   -21.580 -21.783 1.00 44.91 ? 95  ASP   A N   1 
ATOM   576  C CA  . ASP   A 1 95  ? 4.557   -20.905 -21.703 1.00 44.96 ? 95  ASP   A CA  1 
ATOM   577  C C   . ASP   A 1 95  ? 4.369   -19.431 -21.372 1.00 48.39 ? 95  ASP   A C   1 
ATOM   578  O O   . ASP   A 1 95  ? 3.529   -18.750 -21.967 1.00 48.34 ? 95  ASP   A O   1 
ATOM   579  C CB  . ASP   A 1 95  ? 5.322   -21.043 -23.019 1.00 45.02 ? 95  ASP   A CB  1 
ATOM   580  C CG  . ASP   A 1 95  ? 6.030   -22.376 -23.149 1.00 48.18 ? 95  ASP   A CG  1 
ATOM   581  O OD1 . ASP   A 1 95  ? 5.931   -23.198 -22.217 1.00 48.32 ? 95  ASP   A OD1 1 
ATOM   582  O OD2 . ASP   A 1 95  ? 6.692   -22.597 -24.184 1.00 48.94 ? 95  ASP   A OD2 1 
ATOM   583  N N   . ILE   A 1 96  ? 5.151   -18.946 -20.415 1.00 46.54 ? 96  ILE   A N   1 
ATOM   584  C CA  . ILE   A 1 96  ? 5.344   -17.520 -20.183 1.00 45.47 ? 96  ILE   A CA  1 
ATOM   585  C C   . ILE   A 1 96  ? 6.846   -17.286 -20.122 1.00 46.84 ? 96  ILE   A C   1 
ATOM   586  O O   . ILE   A 1 96  ? 7.539   -17.918 -19.314 1.00 46.87 ? 96  ILE   A O   1 
ATOM   587  C CB  . ILE   A 1 96  ? 4.657   -17.033 -18.896 1.00 45.73 ? 96  ILE   A CB  1 
ATOM   588  C CG1 . ILE   A 1 96  ? 3.136   -17.169 -19.007 1.00 44.31 ? 96  ILE   A CG1 1 
ATOM   589  C CG2 . ILE   A 1 96  ? 5.035   -15.591 -18.604 1.00 45.70 ? 96  ILE   A CG2 1 
ATOM   590  C CD1 . ILE   A 1 96  ? 2.389   -16.674 -17.783 1.00 46.09 ? 96  ILE   A CD1 1 
ATOM   591  N N   . ALA   A 1 97  ? 7.348   -16.403 -20.987 1.00 45.52 ? 97  ALA   A N   1 
ATOM   592  C CA  . ALA   A 1 97  ? 8.787   -16.204 -21.115 1.00 47.02 ? 97  ALA   A CA  1 
ATOM   593  C C   . ALA   A 1 97  ? 9.404   -15.826 -19.774 1.00 45.41 ? 97  ALA   A C   1 
ATOM   594  O O   . ALA   A 1 97  ? 8.936   -14.908 -19.094 1.00 46.53 ? 97  ALA   A O   1 
ATOM   595  C CB  . ALA   A 1 97  ? 9.083   -15.125 -22.155 1.00 44.40 ? 97  ALA   A CB  1 
ATOM   596  N N   . GLY   A 1 98  ? 10.459  -16.548 -19.395 1.00 42.51 ? 98  GLY   A N   1 
ATOM   597  C CA  . GLY   A 1 98  ? 11.112  -16.366 -18.122 1.00 43.08 ? 98  GLY   A CA  1 
ATOM   598  C C   . GLY   A 1 98  ? 10.612  -17.272 -17.017 1.00 46.64 ? 98  GLY   A C   1 
ATOM   599  O O   . GLY   A 1 98  ? 11.266  -17.375 -15.974 1.00 46.74 ? 98  GLY   A O   1 
ATOM   600  N N   . LEU   A 1 99  ? 9.483   -17.928 -17.216 1.00 46.60 ? 99  LEU   A N   1 
ATOM   601  C CA  . LEU   A 1 99  ? 8.854   -18.788 -16.232 1.00 46.76 ? 99  LEU   A CA  1 
ATOM   602  C C   . LEU   A 1 99  ? 9.044   -20.251 -16.599 1.00 45.66 ? 99  LEU   A C   1 
ATOM   603  O O   . LEU   A 1 99  ? 9.242   -20.592 -17.770 1.00 45.49 ? 99  LEU   A O   1 
ATOM   604  C CB  . LEU   A 1 99  ? 7.360   -18.465 -16.129 1.00 44.08 ? 99  LEU   A CB  1 
ATOM   605  C CG  . LEU   A 1 99  ? 6.918   -17.632 -14.923 1.00 45.95 ? 99  LEU   A CG  1 
ATOM   606  C CD1 . LEU   A 1 99  ? 7.962   -16.585 -14.556 1.00 47.53 ? 99  LEU   A CD1 1 
ATOM   607  C CD2 . LEU   A 1 99  ? 5.580   -16.970 -15.212 1.00 45.13 ? 99  LEU   A CD2 1 
ATOM   608  N N   . PRO   A 1 100 ? 9.005   -21.147 -15.619 1.00 45.43 ? 100 PRO   A N   1 
ATOM   609  C CA  . PRO   A 1 100 ? 9.168   -22.570 -15.922 1.00 43.21 ? 100 PRO   A CA  1 
ATOM   610  C C   . PRO   A 1 100 ? 7.901   -23.194 -16.486 1.00 43.69 ? 100 PRO   A C   1 
ATOM   611  O O   . PRO   A 1 100 ? 6.778   -22.772 -16.198 1.00 41.81 ? 100 PRO   A O   1 
ATOM   612  C CB  . PRO   A 1 100 ? 9.520   -23.182 -14.561 1.00 42.29 ? 100 PRO   A CB  1 
ATOM   613  C CG  . PRO   A 1 100 ? 8.885   -22.272 -13.575 1.00 41.93 ? 100 PRO   A CG  1 
ATOM   614  C CD  . PRO   A 1 100 ? 8.980   -20.893 -14.167 1.00 41.65 ? 100 PRO   A CD  1 
ATOM   615  N N   . THR   A 1 101 ? 8.107   -24.218 -17.314 1.00 40.92 ? 101 THR   A N   1 
ATOM   616  C CA  . THR   A 1 101 ? 7.039   -25.086 -17.800 1.00 41.42 ? 101 THR   A CA  1 
ATOM   617  C C   . THR   A 1 101 ? 7.499   -26.521 -17.589 1.00 41.79 ? 101 THR   A C   1 
ATOM   618  O O   . THR   A 1 101 ? 8.412   -26.988 -18.277 1.00 42.52 ? 101 THR   A O   1 
ATOM   619  C CB  . THR   A 1 101 ? 6.718   -24.828 -19.272 1.00 44.45 ? 101 THR   A CB  1 
ATOM   620  O OG1 . THR   A 1 101 ? 6.324   -23.461 -19.448 1.00 46.78 ? 101 THR   A OG1 1 
ATOM   621  C CG2 . THR   A 1 101 ? 5.590   -25.741 -19.733 1.00 40.77 ? 101 THR   A CG2 1 
ATOM   622  N N   . SER   A 1 102 ? 6.874   -27.216 -16.640 1.00 39.36 ? 102 SER   A N   1 
ATOM   623  C CA  . SER   A 1 102 ? 7.313   -28.545 -16.244 1.00 40.52 ? 102 SER   A CA  1 
ATOM   624  C C   . SER   A 1 102 ? 6.296   -29.645 -16.501 1.00 40.64 ? 102 SER   A C   1 
ATOM   625  O O   . SER   A 1 102 ? 6.694   -30.813 -16.589 1.00 44.83 ? 102 SER   A O   1 
ATOM   626  C CB  . SER   A 1 102 ? 7.676   -28.561 -14.751 1.00 39.53 ? 102 SER   A CB  1 
ATOM   627  O OG  . SER   A 1 102 ? 6.543   -28.262 -13.955 1.00 37.38 ? 102 SER   A OG  1 
ATOM   628  N N   . TRP   A 1 103 ? 5.011   -29.313 -16.630 1.00 38.87 ? 103 TRP   A N   1 
ATOM   629  C CA  . TRP   A 1 103 ? 3.919   -30.290 -16.674 1.00 41.43 ? 103 TRP   A CA  1 
ATOM   630  C C   . TRP   A 1 103 ? 3.963   -31.249 -15.492 1.00 43.76 ? 103 TRP   A C   1 
ATOM   631  O O   . TRP   A 1 103 ? 3.487   -32.383 -15.589 1.00 44.24 ? 103 TRP   A O   1 
ATOM   632  C CB  . TRP   A 1 103 ? 3.908   -31.084 -17.986 1.00 42.33 ? 103 TRP   A CB  1 
ATOM   633  C CG  . TRP   A 1 103 ? 3.519   -30.282 -19.185 1.00 42.55 ? 103 TRP   A CG  1 
ATOM   634  C CD1 . TRP   A 1 103 ? 3.773   -28.960 -19.408 1.00 43.37 ? 103 TRP   A CD1 1 
ATOM   635  C CD2 . TRP   A 1 103 ? 2.795   -30.749 -20.331 1.00 42.91 ? 103 TRP   A CD2 1 
ATOM   636  N NE1 . TRP   A 1 103 ? 3.257   -28.575 -20.620 1.00 41.64 ? 103 TRP   A NE1 1 
ATOM   637  C CE2 . TRP   A 1 103 ? 2.650   -29.654 -21.207 1.00 42.51 ? 103 TRP   A CE2 1 
ATOM   638  C CE3 . TRP   A 1 103 ? 2.255   -31.984 -20.701 1.00 45.14 ? 103 TRP   A CE3 1 
ATOM   639  C CZ2 . TRP   A 1 103 ? 1.991   -29.757 -22.428 1.00 43.70 ? 103 TRP   A CZ2 1 
ATOM   640  C CZ3 . TRP   A 1 103 ? 1.600   -32.082 -21.917 1.00 43.58 ? 103 TRP   A CZ3 1 
ATOM   641  C CH2 . TRP   A 1 103 ? 1.476   -30.976 -22.765 1.00 45.57 ? 103 TRP   A CH2 1 
ATOM   642  N N   . GLY   A 1 104 ? 4.517   -30.809 -14.365 1.00 41.93 ? 104 GLY   A N   1 
ATOM   643  C CA  . GLY   A 1 104 ? 4.565   -31.622 -13.174 1.00 45.33 ? 104 GLY   A CA  1 
ATOM   644  C C   . GLY   A 1 104 ? 5.761   -32.535 -13.070 1.00 44.63 ? 104 GLY   A C   1 
ATOM   645  O O   . GLY   A 1 104 ? 6.043   -33.033 -11.971 1.00 47.44 ? 104 GLY   A O   1 
ATOM   646  N N   . PHE   A 1 105 ? 6.476   -32.772 -14.166 1.00 43.56 ? 105 PHE   A N   1 
ATOM   647  C CA  . PHE   A 1 105 ? 7.626   -33.663 -14.131 1.00 45.70 ? 105 PHE   A CA  1 
ATOM   648  C C   . PHE   A 1 105 ? 8.753   -33.044 -13.313 1.00 45.29 ? 105 PHE   A C   1 
ATOM   649  O O   . PHE   A 1 105 ? 9.088   -31.868 -13.484 1.00 45.12 ? 105 PHE   A O   1 
ATOM   650  C CB  . PHE   A 1 105 ? 8.104   -33.962 -15.550 1.00 46.88 ? 105 PHE   A CB  1 
ATOM   651  C CG  . PHE   A 1 105 ? 7.064   -34.614 -16.419 1.00 46.74 ? 105 PHE   A CG  1 
ATOM   652  C CD1 . PHE   A 1 105 ? 6.783   -35.964 -16.290 1.00 47.07 ? 105 PHE   A CD1 1 
ATOM   653  C CD2 . PHE   A 1 105 ? 6.377   -33.881 -17.372 1.00 44.40 ? 105 PHE   A CD2 1 
ATOM   654  C CE1 . PHE   A 1 105 ? 5.831   -36.570 -17.090 1.00 45.12 ? 105 PHE   A CE1 1 
ATOM   655  C CE2 . PHE   A 1 105 ? 5.422   -34.481 -18.175 1.00 46.71 ? 105 PHE   A CE2 1 
ATOM   656  C CZ  . PHE   A 1 105 ? 5.150   -35.827 -18.034 1.00 47.18 ? 105 PHE   A CZ  1 
ATOM   657  N N   . ALA   A 1 106 ? 9.335   -33.838 -12.413 1.00 46.22 ? 106 ALA   A N   1 
ATOM   658  C CA  . ALA   A 1 106 ? 10.493  -33.367 -11.662 1.00 46.31 ? 106 ALA   A CA  1 
ATOM   659  C C   . ALA   A 1 106 ? 11.693  -33.137 -12.571 1.00 47.35 ? 106 ALA   A C   1 
ATOM   660  O O   . ALA   A 1 106 ? 12.566  -32.322 -12.251 1.00 46.56 ? 106 ALA   A O   1 
ATOM   661  C CB  . ALA   A 1 106 ? 10.846  -34.362 -10.555 1.00 42.99 ? 106 ALA   A CB  1 
ATOM   662  N N   . GLU   A 1 107 ? 11.745  -33.834 -13.709 1.00 46.39 ? 107 GLU   A N   1 
ATOM   663  C CA  . GLU   A 1 107 ? 12.880  -33.720 -14.616 1.00 46.93 ? 107 GLU   A CA  1 
ATOM   664  C C   . GLU   A 1 107 ? 12.864  -32.421 -15.407 1.00 46.53 ? 107 GLU   A C   1 
ATOM   665  O O   . GLU   A 1 107 ? 13.905  -32.022 -15.943 1.00 46.43 ? 107 GLU   A O   1 
ATOM   666  C CB  . GLU   A 1 107 ? 12.907  -34.907 -15.586 1.00 48.88 ? 107 GLU   A CB  1 
ATOM   667  C CG  . GLU   A 1 107 ? 12.596  -36.257 -14.952 1.00 56.04 ? 107 GLU   A CG  1 
ATOM   668  C CD  . GLU   A 1 107 ? 11.108  -36.544 -14.871 1.00 53.15 ? 107 GLU   A CD  1 
ATOM   669  O OE1 . GLU   A 1 107 ? 10.453  -36.612 -15.931 1.00 58.31 ? 107 GLU   A OE1 1 
ATOM   670  O OE2 . GLU   A 1 107 ? 10.590  -36.698 -13.745 1.00 45.96 ? 107 GLU   A OE2 1 
ATOM   671  N N   . HIS   A 1 108 ? 11.709  -31.763 -15.499 1.00 43.76 ? 108 HIS   A N   1 
ATOM   672  C CA  . HIS   A 1 108 ? 11.543  -30.537 -16.267 1.00 45.75 ? 108 HIS   A CA  1 
ATOM   673  C C   . HIS   A 1 108 ? 11.230  -29.344 -15.371 1.00 46.58 ? 108 HIS   A C   1 
ATOM   674  O O   . HIS   A 1 108 ? 10.632  -28.366 -15.821 1.00 47.18 ? 108 HIS   A O   1 
ATOM   675  C CB  . HIS   A 1 108 ? 10.446  -30.711 -17.315 1.00 43.12 ? 108 HIS   A CB  1 
ATOM   676  C CG  . HIS   A 1 108 ? 10.620  -31.917 -18.185 1.00 44.12 ? 108 HIS   A CG  1 
ATOM   677  N ND1 . HIS   A 1 108 ? 11.744  -32.125 -18.954 1.00 41.72 ? 108 HIS   A ND1 1 
ATOM   678  C CD2 . HIS   A 1 108 ? 9.809   -32.979 -18.410 1.00 43.90 ? 108 HIS   A CD2 1 
ATOM   679  C CE1 . HIS   A 1 108 ? 11.619  -33.262 -19.615 1.00 45.91 ? 108 HIS   A CE1 1 
ATOM   680  N NE2 . HIS   A 1 108 ? 10.453  -33.800 -19.303 1.00 43.62 ? 108 HIS   A NE2 1 
ATOM   681  N N   . ALA   A 1 109 ? 11.631  -29.416 -14.100 1.00 44.55 ? 109 ALA   A N   1 
ATOM   682  C CA  . ALA   A 1 109 ? 11.344  -28.340 -13.156 1.00 44.59 ? 109 ALA   A CA  1 
ATOM   683  C C   . ALA   A 1 109 ? 12.105  -27.068 -13.500 1.00 43.52 ? 109 ALA   A C   1 
ATOM   684  O O   . ALA   A 1 109 ? 11.593  -25.963 -13.281 1.00 43.86 ? 109 ALA   A O   1 
ATOM   685  C CB  . ALA   A 1 109 ? 11.678  -28.789 -11.730 1.00 43.49 ? 109 ALA   A CB  1 
ATOM   686  N N   . ASP   A 1 110 ? 13.319  -27.197 -14.038 1.00 41.79 ? 110 ASP   A N   1 
ATOM   687  C CA  . ASP   A 1 110 ? 14.146  -26.049 -14.378 1.00 44.13 ? 110 ASP   A CA  1 
ATOM   688  C C   . ASP   A 1 110 ? 14.152  -25.750 -15.875 1.00 46.38 ? 110 ASP   A C   1 
ATOM   689  O O   . ASP   A 1 110 ? 15.076  -25.093 -16.364 1.00 45.52 ? 110 ASP   A O   1 
ATOM   690  C CB  . ASP   A 1 110 ? 15.574  -26.253 -13.867 1.00 41.76 ? 110 ASP   A CB  1 
ATOM   691  C CG  . ASP   A 1 110 ? 16.145  -27.602 -14.249 1.00 47.92 ? 110 ASP   A CG  1 
ATOM   692  O OD1 . ASP   A 1 110 ? 15.374  -28.467 -14.714 1.00 49.33 ? 110 ASP   A OD1 1 
ATOM   693  O OD2 . ASP   A 1 110 ? 17.369  -27.792 -14.087 1.00 49.25 ? 110 ASP   A OD2 1 
ATOM   694  N N   . HIS   A 1 111 ? 13.139  -26.208 -16.609 1.00 45.83 ? 111 HIS   A N   1 
ATOM   695  C CA  . HIS   A 1 111 ? 12.959  -25.787 -17.994 1.00 46.02 ? 111 HIS   A CA  1 
ATOM   696  C C   . HIS   A 1 111 ? 12.231  -24.449 -18.015 1.00 45.99 ? 111 HIS   A C   1 
ATOM   697  O O   . HIS   A 1 111 ? 11.066  -24.368 -17.615 1.00 45.52 ? 111 HIS   A O   1 
ATOM   698  C CB  . HIS   A 1 111 ? 12.180  -26.830 -18.791 1.00 44.77 ? 111 HIS   A CB  1 
ATOM   699  C CG  . HIS   A 1 111 ? 11.691  -26.329 -20.116 1.00 49.58 ? 111 HIS   A CG  1 
ATOM   700  N ND1 . HIS   A 1 111 ? 10.381  -25.961 -20.335 1.00 48.82 ? 111 HIS   A ND1 1 
ATOM   701  C CD2 . HIS   A 1 111 ? 12.342  -26.118 -21.284 1.00 46.25 ? 111 HIS   A CD2 1 
ATOM   702  C CE1 . HIS   A 1 111 ? 10.243  -25.554 -21.585 1.00 46.58 ? 111 HIS   A CE1 1 
ATOM   703  N NE2 . HIS   A 1 111 ? 11.418  -25.642 -22.183 1.00 47.11 ? 111 HIS   A NE2 1 
ATOM   704  N N   . ILE   A 1 112 ? 12.914  -23.404 -18.475 1.00 46.50 ? 112 ILE   A N   1 
ATOM   705  C CA  . ILE   A 1 112 ? 12.374  -22.050 -18.490 1.00 46.14 ? 112 ILE   A CA  1 
ATOM   706  C C   . ILE   A 1 112 ? 12.046  -21.682 -19.929 1.00 47.81 ? 112 ILE   A C   1 
ATOM   707  O O   . ILE   A 1 112 ? 12.893  -21.817 -20.821 1.00 52.63 ? 112 ILE   A O   1 
ATOM   708  C CB  . ILE   A 1 112 ? 13.355  -21.044 -17.861 1.00 47.58 ? 112 ILE   A CB  1 
ATOM   709  C CG1 . ILE   A 1 112 ? 13.183  -20.999 -16.339 1.00 48.15 ? 112 ILE   A CG1 1 
ATOM   710  C CG2 . ILE   A 1 112 ? 13.167  -19.655 -18.459 1.00 46.60 ? 112 ILE   A CG2 1 
ATOM   711  C CD1 . ILE   A 1 112 ? 13.676  -22.233 -15.610 1.00 47.97 ? 112 ILE   A CD1 1 
ATOM   712  N N   . ALA   A 1 113 ? 10.814  -21.233 -20.155 1.00 46.52 ? 113 ALA   A N   1 
ATOM   713  C CA  . ALA   A 1 113 ? 10.391  -20.826 -21.486 1.00 49.39 ? 113 ALA   A CA  1 
ATOM   714  C C   . ALA   A 1 113 ? 11.049  -19.509 -21.882 1.00 48.35 ? 113 ALA   A C   1 
ATOM   715  O O   . ALA   A 1 113 ? 11.290  -18.632 -21.048 1.00 47.36 ? 113 ALA   A O   1 
ATOM   716  C CB  . ALA   A 1 113 ? 8.870   -20.687 -21.538 1.00 48.52 ? 113 ALA   A CB  1 
ATOM   717  N N   . THR   A 1 114 ? 11.340  -19.374 -23.175 1.00 47.76 ? 114 THR   A N   1 
ATOM   718  C CA  . THR   A 1 114 ? 11.968  -18.174 -23.708 1.00 46.88 ? 114 THR   A CA  1 
ATOM   719  C C   . THR   A 1 114 ? 11.010  -17.328 -24.535 1.00 46.54 ? 114 THR   A C   1 
ATOM   720  O O   . THR   A 1 114 ? 11.399  -16.250 -24.999 1.00 44.10 ? 114 THR   A O   1 
ATOM   721  C CB  . THR   A 1 114 ? 13.190  -18.544 -24.559 1.00 44.47 ? 114 THR   A CB  1 
ATOM   722  O OG1 . THR   A 1 114 ? 12.760  -18.921 -25.872 1.00 48.01 ? 114 THR   A OG1 1 
ATOM   723  C CG2 . THR   A 1 114 ? 13.938  -19.711 -23.937 1.00 44.63 ? 114 THR   A CG2 1 
ATOM   724  N N   . ALA   A 1 115 ? 9.775   -17.784 -24.730 1.00 47.89 ? 115 ALA   A N   1 
ATOM   725  C CA  . ALA   A 1 115 ? 8.793   -17.043 -25.505 1.00 46.63 ? 115 ALA   A CA  1 
ATOM   726  C C   . ALA   A 1 115 ? 7.410   -17.295 -24.924 1.00 46.34 ? 115 ALA   A C   1 
ATOM   727  O O   . ALA   A 1 115 ? 7.121   -18.379 -24.415 1.00 46.91 ? 115 ALA   A O   1 
ATOM   728  C CB  . ALA   A 1 115 ? 8.832   -17.437 -26.985 1.00 40.78 ? 115 ALA   A CB  1 
ATOM   729  N N   . ASP   A 1 116 ? 6.560   -16.279 -25.004 1.00 44.47 ? 116 ASP   A N   1 
ATOM   730  C CA  . ASP   A 1 116 ? 5.191   -16.391 -24.524 1.00 44.65 ? 116 ASP   A CA  1 
ATOM   731  C C   . ASP   A 1 116 ? 4.349   -17.224 -25.483 1.00 46.59 ? 116 ASP   A C   1 
ATOM   732  O O   . ASP   A 1 116 ? 4.540   -17.176 -26.701 1.00 44.83 ? 116 ASP   A O   1 
ATOM   733  C CB  . ASP   A 1 116 ? 4.569   -15.003 -24.358 1.00 45.82 ? 116 ASP   A CB  1 
ATOM   734  C CG  . ASP   A 1 116 ? 5.069   -14.283 -23.121 1.00 49.83 ? 116 ASP   A CG  1 
ATOM   735  O OD1 . ASP   A 1 116 ? 5.801   -14.905 -22.321 1.00 49.65 ? 116 ASP   A OD1 1 
ATOM   736  O OD2 . ASP   A 1 116 ? 4.728   -13.097 -22.948 1.00 51.62 ? 116 ASP   A OD2 1 
ATOM   737  N N   . SER   A 1 117 ? 3.417   -17.993 -24.925 1.00 46.08 ? 117 SER   A N   1 
ATOM   738  C CA  . SER   A 1 117 ? 2.478   -18.734 -25.752 1.00 43.45 ? 117 SER   A CA  1 
ATOM   739  C C   . SER   A 1 117 ? 1.539   -17.776 -26.484 1.00 43.72 ? 117 SER   A C   1 
ATOM   740  O O   . SER   A 1 117 ? 1.414   -16.597 -26.137 1.00 44.77 ? 117 SER   A O   1 
ATOM   741  C CB  . SER   A 1 117 ? 1.675   -19.720 -24.902 1.00 44.74 ? 117 SER   A CB  1 
ATOM   742  O OG  . SER   A 1 117 ? 0.958   -19.057 -23.879 1.00 46.40 ? 117 SER   A OG  1 
ATOM   743  N N   . LEU   A 1 118 ? 0.879   -18.301 -27.521 1.00 46.95 ? 118 LEU   A N   1 
ATOM   744  C CA  . LEU   A 1 118 ? -0.033  -17.483 -28.317 1.00 45.00 ? 118 LEU   A CA  1 
ATOM   745  C C   . LEU   A 1 118 ? -1.165  -16.926 -27.462 1.00 47.51 ? 118 LEU   A C   1 
ATOM   746  O O   . LEU   A 1 118 ? -1.521  -15.748 -27.583 1.00 46.84 ? 118 LEU   A O   1 
ATOM   747  C CB  . LEU   A 1 118 ? -0.586  -18.306 -29.484 1.00 41.85 ? 118 LEU   A CB  1 
ATOM   748  C CG  . LEU   A 1 118 ? -1.364  -17.614 -30.612 1.00 46.93 ? 118 LEU   A CG  1 
ATOM   749  C CD1 . LEU   A 1 118 ? -2.838  -17.398 -30.269 1.00 44.85 ? 118 LEU   A CD1 1 
ATOM   750  C CD2 . LEU   A 1 118 ? -0.701  -16.303 -30.999 1.00 44.17 ? 118 LEU   A CD2 1 
ATOM   751  N N   . VAL   A 1 119 ? -1.740  -17.759 -26.592 1.00 43.16 ? 119 VAL   A N   1 
ATOM   752  C CA  . VAL   A 1 119 ? -2.847  -17.313 -25.749 1.00 44.74 ? 119 VAL   A CA  1 
ATOM   753  C C   . VAL   A 1 119 ? -2.382  -16.231 -24.783 1.00 44.48 ? 119 VAL   A C   1 
ATOM   754  O O   . VAL   A 1 119 ? -3.092  -15.246 -24.542 1.00 44.73 ? 119 VAL   A O   1 
ATOM   755  C CB  . VAL   A 1 119 ? -3.470  -18.513 -25.010 1.00 44.75 ? 119 VAL   A CB  1 
ATOM   756  C CG1 . VAL   A 1 119 ? -4.123  -18.066 -23.712 1.00 40.34 ? 119 VAL   A CG1 1 
ATOM   757  C CG2 . VAL   A 1 119 ? -4.480  -19.216 -25.900 1.00 40.49 ? 119 VAL   A CG2 1 
ATOM   758  N N   . VAL   A 1 120 ? -1.179  -16.385 -24.226 1.00 44.14 ? 120 VAL   A N   1 
ATOM   759  C CA  . VAL   A 1 120 ? -0.639  -15.356 -23.344 1.00 43.04 ? 120 VAL   A CA  1 
ATOM   760  C C   . VAL   A 1 120 ? -0.370  -14.073 -24.122 1.00 43.03 ? 120 VAL   A C   1 
ATOM   761  O O   . VAL   A 1 120 ? -0.607  -12.967 -23.621 1.00 42.33 ? 120 VAL   A O   1 
ATOM   762  C CB  . VAL   A 1 120 ? 0.628   -15.872 -22.638 1.00 44.54 ? 120 VAL   A CB  1 
ATOM   763  C CG1 . VAL   A 1 120 ? 1.330   -14.741 -21.914 1.00 44.95 ? 120 VAL   A CG1 1 
ATOM   764  C CG2 . VAL   A 1 120 ? 0.270   -16.971 -21.657 1.00 43.77 ? 120 VAL   A CG2 1 
ATOM   765  N N   . SER   A 1 121 ? 0.115   -14.197 -25.360 1.00 43.18 ? 121 SER   A N   1 
ATOM   766  C CA  . SER   A 1 121 ? 0.396   -13.009 -26.159 1.00 42.10 ? 121 SER   A CA  1 
ATOM   767  C C   . SER   A 1 121 ? -0.879  -12.235 -26.460 1.00 41.20 ? 121 SER   A C   1 
ATOM   768  O O   . SER   A 1 121 ? -0.899  -11.000 -26.376 1.00 40.81 ? 121 SER   A O   1 
ATOM   769  C CB  . SER   A 1 121 ? 1.110   -13.404 -27.453 1.00 43.21 ? 121 SER   A CB  1 
ATOM   770  O OG  . SER   A 1 121 ? 2.374   -13.983 -27.173 1.00 48.32 ? 121 SER   A OG  1 
ATOM   771  N N   . ARG   A 1 122 ? -1.961  -12.945 -26.790 1.00 42.05 ? 122 ARG   A N   1 
ATOM   772  C CA  . ARG   A 1 122 ? -3.227  -12.281 -27.079 1.00 41.24 ? 122 ARG   A CA  1 
ATOM   773  C C   . ARG   A 1 122 ? -3.781  -11.581 -25.843 1.00 42.65 ? 122 ARG   A C   1 
ATOM   774  O O   . ARG   A 1 122 ? -4.230  -10.430 -25.916 1.00 43.07 ? 122 ARG   A O   1 
ATOM   775  C CB  . ARG   A 1 122 ? -4.234  -13.297 -27.615 1.00 39.22 ? 122 ARG   A CB  1 
ATOM   776  C CG  . ARG   A 1 122 ? -3.888  -13.864 -28.978 1.00 43.62 ? 122 ARG   A CG  1 
ATOM   777  C CD  . ARG   A 1 122 ? -4.174  -12.862 -30.082 1.00 40.94 ? 122 ARG   A CD  1 
ATOM   778  N NE  . ARG   A 1 122 ? -4.350  -13.520 -31.371 1.00 43.25 ? 122 ARG   A NE  1 
ATOM   779  C CZ  . ARG   A 1 122 ? -5.496  -14.029 -31.802 1.00 43.28 ? 122 ARG   A CZ  1 
ATOM   780  N NH1 . ARG   A 1 122 ? -6.596  -13.977 -31.068 1.00 40.30 ? 122 ARG   A NH1 1 
ATOM   781  N NH2 . ARG   A 1 122 ? -5.542  -14.604 -33.001 1.00 39.51 ? 122 ARG   A NH2 1 
ATOM   782  N N   . LEU   A 1 123 ? -3.764  -12.262 -24.695 1.00 44.08 ? 123 LEU   A N   1 
ATOM   783  C CA  . LEU   A 1 123 ? -4.289  -11.660 -23.473 1.00 43.39 ? 123 LEU   A CA  1 
ATOM   784  C C   . LEU   A 1 123 ? -3.434  -10.482 -23.021 1.00 42.55 ? 123 LEU   A C   1 
ATOM   785  O O   . LEU   A 1 123 ? -3.959  -9.496  -22.491 1.00 42.15 ? 123 LEU   A O   1 
ATOM   786  C CB  . LEU   A 1 123 ? -4.388  -12.716 -22.371 1.00 42.25 ? 123 LEU   A CB  1 
ATOM   787  C CG  . LEU   A 1 123 ? -5.465  -13.781 -22.580 1.00 42.23 ? 123 LEU   A CG  1 
ATOM   788  C CD1 . LEU   A 1 123 ? -5.218  -14.973 -21.675 1.00 39.43 ? 123 LEU   A CD1 1 
ATOM   789  C CD2 . LEU   A 1 123 ? -6.848  -13.191 -22.335 1.00 39.41 ? 123 LEU   A CD2 1 
ATOM   790  N N   . LYS   A 1 124 ? -2.117  -10.563 -23.226 1.00 43.65 ? 124 LYS   A N   1 
ATOM   791  C CA  . LYS   A 1 124 ? -1.243  -9.447  -22.877 1.00 46.13 ? 124 LYS   A CA  1 
ATOM   792  C C   . LYS   A 1 124 ? -1.502  -8.246  -23.776 1.00 43.88 ? 124 LYS   A C   1 
ATOM   793  O O   . LYS   A 1 124 ? -1.553  -7.102  -23.306 1.00 42.99 ? 124 LYS   A O   1 
ATOM   794  C CB  . LYS   A 1 124 ? 0.222   -9.869  -22.973 1.00 41.94 ? 124 LYS   A CB  1 
ATOM   795  C CG  . LYS   A 1 124 ? 0.724   -10.703 -21.810 1.00 43.65 ? 124 LYS   A CG  1 
ATOM   796  C CD  . LYS   A 1 124 ? 2.226   -10.897 -21.909 1.00 47.38 ? 124 LYS   A CD  1 
ATOM   797  C CE  . LYS   A 1 124 ? 2.758   -11.684 -20.731 1.00 43.65 ? 124 LYS   A CE  1 
ATOM   798  N NZ  . LYS   A 1 124 ? 4.249   -11.761 -20.726 1.00 47.81 ? 124 LYS   A NZ  1 
ATOM   799  N N   . ALA   A 1 125 ? -1.657  -8.490  -25.080 1.00 42.25 ? 125 ALA   A N   1 
ATOM   800  C CA  . ALA   A 1 125 ? -1.929  -7.401  -26.012 1.00 44.96 ? 125 ALA   A CA  1 
ATOM   801  C C   . ALA   A 1 125 ? -3.211  -6.663  -25.655 1.00 46.07 ? 125 ALA   A C   1 
ATOM   802  O O   . ALA   A 1 125 ? -3.367  -5.488  -26.004 1.00 45.79 ? 125 ALA   A O   1 
ATOM   803  C CB  . ALA   A 1 125 ? -2.000  -7.936  -27.442 1.00 43.45 ? 125 ALA   A CB  1 
ATOM   804  N N   . ALA   A 1 126 ? -4.135  -7.325  -24.964 1.00 48.18 ? 126 ALA   A N   1 
ATOM   805  C CA  . ALA   A 1 126 ? -5.343  -6.680  -24.475 1.00 43.00 ? 126 ALA   A CA  1 
ATOM   806  C C   . ALA   A 1 126 ? -5.166  -6.080  -23.084 1.00 46.70 ? 126 ALA   A C   1 
ATOM   807  O O   . ALA   A 1 126 ? -6.141  -5.594  -22.504 1.00 50.34 ? 126 ALA   A O   1 
ATOM   808  C CB  . ALA   A 1 126 ? -6.511  -7.668  -24.477 1.00 44.28 ? 126 ALA   A CB  1 
ATOM   809  N N   . GLY   A 1 127 ? -3.954  -6.117  -22.534 1.00 44.43 ? 127 GLY   A N   1 
ATOM   810  C CA  . GLY   A 1 127 ? -3.634  -5.421  -21.305 1.00 45.80 ? 127 GLY   A CA  1 
ATOM   811  C C   . GLY   A 1 127 ? -3.571  -6.273  -20.057 1.00 44.89 ? 127 GLY   A C   1 
ATOM   812  O O   . GLY   A 1 127 ? -3.289  -5.734  -18.979 1.00 48.00 ? 127 GLY   A O   1 
ATOM   813  N N   . ALA   A 1 128 ? -3.826  -7.575  -20.158 1.00 43.43 ? 128 ALA   A N   1 
ATOM   814  C CA  . ALA   A 1 128 ? -3.875  -8.414  -18.969 1.00 45.54 ? 128 ALA   A CA  1 
ATOM   815  C C   . ALA   A 1 128 ? -2.492  -8.551  -18.346 1.00 47.42 ? 128 ALA   A C   1 
ATOM   816  O O   . ALA   A 1 128 ? -1.480  -8.632  -19.048 1.00 46.96 ? 128 ALA   A O   1 
ATOM   817  C CB  . ALA   A 1 128 ? -4.438  -9.792  -19.311 1.00 43.16 ? 128 ALA   A CB  1 
ATOM   818  N N   . VAL   A 1 129 ? -2.454  -8.575  -17.016 1.00 43.03 ? 129 VAL   A N   1 
ATOM   819  C CA  . VAL   A 1 129 ? -1.220  -8.728  -16.255 1.00 47.66 ? 129 VAL   A CA  1 
ATOM   820  C C   . VAL   A 1 129 ? -1.200  -10.130 -15.662 1.00 45.79 ? 129 VAL   A C   1 
ATOM   821  O O   . VAL   A 1 129 ? -2.157  -10.542 -14.994 1.00 48.33 ? 129 VAL   A O   1 
ATOM   822  C CB  . VAL   A 1 129 ? -1.101  -7.658  -15.157 1.00 50.51 ? 129 VAL   A CB  1 
ATOM   823  C CG1 . VAL   A 1 129 ? 0.324   -7.591  -14.641 1.00 48.62 ? 129 VAL   A CG1 1 
ATOM   824  C CG2 . VAL   A 1 129 ? -1.554  -6.303  -15.690 1.00 48.32 ? 129 VAL   A CG2 1 
ATOM   825  N N   . PHE   A 1 130 ? -0.119  -10.866 -15.915 1.00 45.00 ? 130 PHE   A N   1 
ATOM   826  C CA  . PHE   A 1 130 ? 0.011   -12.251 -15.472 1.00 45.93 ? 130 PHE   A CA  1 
ATOM   827  C C   . PHE   A 1 130 ? 0.866   -12.286 -14.211 1.00 49.99 ? 130 PHE   A C   1 
ATOM   828  O O   . PHE   A 1 130 ? 2.055   -11.955 -14.249 1.00 47.04 ? 130 PHE   A O   1 
ATOM   829  C CB  . PHE   A 1 130 ? 0.610   -13.123 -16.572 1.00 48.17 ? 130 PHE   A CB  1 
ATOM   830  C CG  . PHE   A 1 130 ? -0.380  -13.532 -17.621 1.00 45.46 ? 130 PHE   A CG  1 
ATOM   831  C CD1 . PHE   A 1 130 ? -0.658  -12.699 -18.689 1.00 43.03 ? 130 PHE   A CD1 1 
ATOM   832  C CD2 . PHE   A 1 130 ? -1.042  -14.746 -17.531 1.00 42.18 ? 130 PHE   A CD2 1 
ATOM   833  C CE1 . PHE   A 1 130 ? -1.573  -13.068 -19.654 1.00 43.60 ? 130 PHE   A CE1 1 
ATOM   834  C CE2 . PHE   A 1 130 ? -1.958  -15.124 -18.493 1.00 42.47 ? 130 PHE   A CE2 1 
ATOM   835  C CZ  . PHE   A 1 130 ? -2.225  -14.283 -19.557 1.00 44.22 ? 130 PHE   A CZ  1 
ATOM   836  N N   . LEU   A 1 131 ? 0.250   -12.684 -13.096 1.00 47.97 ? 131 LEU   A N   1 
ATOM   837  C CA  . LEU   A 1 131 ? 0.945   -12.763 -11.816 1.00 50.19 ? 131 LEU   A CA  1 
ATOM   838  C C   . LEU   A 1 131 ? 1.707   -14.069 -11.653 1.00 47.46 ? 131 LEU   A C   1 
ATOM   839  O O   . LEU   A 1 131 ? 2.736   -14.099 -10.969 1.00 50.09 ? 131 LEU   A O   1 
ATOM   840  C CB  . LEU   A 1 131 ? -0.055  -12.611 -10.669 1.00 47.93 ? 131 LEU   A CB  1 
ATOM   841  C CG  . LEU   A 1 131 ? -1.074  -11.483 -10.784 1.00 50.04 ? 131 LEU   A CG  1 
ATOM   842  C CD1 . LEU   A 1 131 ? -2.239  -11.752 -9.849  1.00 44.75 ? 131 LEU   A CD1 1 
ATOM   843  C CD2 . LEU   A 1 131 ? -0.432  -10.147 -10.461 1.00 48.45 ? 131 LEU   A CD2 1 
ATOM   844  N N   . GLY   A 1 132 ? 1.220   -15.148 -12.251 1.00 47.37 ? 132 GLY   A N   1 
ATOM   845  C CA  . GLY   A 1 132 ? 1.885   -16.425 -12.112 1.00 48.85 ? 132 GLY   A CA  1 
ATOM   846  C C   . GLY   A 1 132 ? 1.139   -17.513 -12.848 1.00 45.22 ? 132 GLY   A C   1 
ATOM   847  O O   . GLY   A 1 132 ? 0.376   -17.242 -13.777 1.00 43.63 ? 132 GLY   A O   1 
ATOM   848  N N   . LYS   A 1 133 ? 1.361   -18.756 -12.418 1.00 41.16 ? 133 LYS   A N   1 
ATOM   849  C CA  . LYS   A 1 133 ? 0.796   -19.912 -13.099 1.00 41.53 ? 133 LYS   A CA  1 
ATOM   850  C C   . LYS   A 1 133 ? 0.300   -20.935 -12.085 1.00 41.84 ? 133 LYS   A C   1 
ATOM   851  O O   . LYS   A 1 133 ? 0.855   -21.072 -10.992 1.00 41.35 ? 133 LYS   A O   1 
ATOM   852  C CB  . LYS   A 1 133 ? 1.820   -20.534 -14.061 1.00 39.34 ? 133 LYS   A CB  1 
ATOM   853  C CG  . LYS   A 1 133 ? 1.997   -19.720 -15.341 1.00 43.39 ? 133 LYS   A CG  1 
ATOM   854  C CD  . LYS   A 1 133 ? 3.351   -19.944 -15.991 1.00 42.59 ? 133 LYS   A CD  1 
ATOM   855  C CE  . LYS   A 1 133 ? 3.561   -21.402 -16.341 1.00 41.02 ? 133 LYS   A CE  1 
ATOM   856  N NZ  . LYS   A 1 133 ? 4.759   -21.601 -17.206 1.00 43.88 ? 133 LYS   A NZ  1 
ATOM   857  N N   . SER   A 1 134 ? -0.752  -21.658 -12.467 1.00 40.77 ? 134 SER   A N   1 
ATOM   858  C CA  . SER   A 1 134 ? -1.517  -22.498 -11.555 1.00 38.86 ? 134 SER   A CA  1 
ATOM   859  C C   . SER   A 1 134 ? -1.126  -23.970 -11.670 1.00 37.85 ? 134 SER   A C   1 
ATOM   860  O O   . SER   A 1 134 ? -0.518  -24.405 -12.649 1.00 40.04 ? 134 SER   A O   1 
ATOM   861  C CB  . SER   A 1 134 ? -3.018  -22.333 -11.809 1.00 38.86 ? 134 SER   A CB  1 
ATOM   862  O OG  . SER   A 1 134 ? -3.332  -22.528 -13.176 1.00 40.74 ? 134 SER   A OG  1 
ATOM   863  N N   . ASN   A 1 135 ? -1.516  -24.738 -10.653 1.00 35.73 ? 135 ASN   A N   1 
ATOM   864  C CA  . ASN   A 1 135 ? -1.004  -26.087 -10.452 1.00 37.43 ? 135 ASN   A CA  1 
ATOM   865  C C   . ASN   A 1 135 ? -1.659  -27.095 -11.390 1.00 40.60 ? 135 ASN   A C   1 
ATOM   866  O O   . ASN   A 1 135 ? -2.784  -26.907 -11.859 1.00 38.14 ? 135 ASN   A O   1 
ATOM   867  C CB  . ASN   A 1 135 ? -1.219  -26.525 -9.005  1.00 39.49 ? 135 ASN   A CB  1 
ATOM   868  C CG  . ASN   A 1 135 ? -0.375  -27.723 -8.630  1.00 38.68 ? 135 ASN   A CG  1 
ATOM   869  O OD1 . ASN   A 1 135 ? 0.704   -27.933 -9.188  1.00 39.70 ? 135 ASN   A OD1 1 
ATOM   870  N ND2 . ASN   A 1 135 ? -0.862  -28.522 -7.687  1.00 40.39 ? 135 ASN   A ND2 1 
ATOM   871  N N   . ILE   A 1 136 ? -0.942  -28.190 -11.633 1.00 39.18 ? 136 ILE   A N   1 
ATOM   872  C CA  . ILE   A 1 136 ? -1.335  -29.217 -12.594 1.00 40.42 ? 136 ILE   A CA  1 
ATOM   873  C C   . ILE   A 1 136 ? -0.868  -30.580 -12.087 1.00 40.17 ? 136 ILE   A C   1 
ATOM   874  O O   . ILE   A 1 136 ? 0.011   -30.644 -11.215 1.00 43.24 ? 136 ILE   A O   1 
ATOM   875  C CB  . ILE   A 1 136 ? -0.755  -28.912 -13.986 1.00 42.56 ? 136 ILE   A CB  1 
ATOM   876  C CG1 . ILE   A 1 136 ? 0.692   -28.443 -13.875 1.00 44.56 ? 136 ILE   A CG1 1 
ATOM   877  C CG2 . ILE   A 1 136 ? -1.533  -27.827 -14.677 1.00 39.07 ? 136 ILE   A CG2 1 
ATOM   878  C CD1 . ILE   A 1 136 ? 1.680   -29.546 -13.798 1.00 45.05 ? 136 ILE   A CD1 1 
ATOM   879  N N   . PRO   A 1 137 ? -1.418  -31.682 -12.585 1.00 41.96 ? 137 PRO   A N   1 
ATOM   880  C CA  . PRO   A 1 137 ? -0.851  -33.000 -12.292 1.00 41.74 ? 137 PRO   A CA  1 
ATOM   881  C C   . PRO   A 1 137 ? 0.293   -33.329 -13.242 1.00 43.14 ? 137 PRO   A C   1 
ATOM   882  O O   . PRO   A 1 137 ? 0.563   -32.620 -14.212 1.00 44.99 ? 137 PRO   A O   1 
ATOM   883  C CB  . PRO   A 1 137 ? -2.035  -33.944 -12.514 1.00 41.98 ? 137 PRO   A CB  1 
ATOM   884  C CG  . PRO   A 1 137 ? -2.808  -33.273 -13.588 1.00 42.93 ? 137 PRO   A CG  1 
ATOM   885  C CD  . PRO   A 1 137 ? -2.712  -31.799 -13.270 1.00 43.39 ? 137 PRO   A CD  1 
ATOM   886  N N   . VAL   A 1 138 ? 0.956   -34.445 -12.948 1.00 43.24 ? 138 VAL   A N   1 
ATOM   887  C CA  . VAL   A 1 138 ? 2.109   -34.870 -13.733 1.00 46.85 ? 138 VAL   A CA  1 
ATOM   888  C C   . VAL   A 1 138 ? 1.643   -35.303 -15.117 1.00 43.71 ? 138 VAL   A C   1 
ATOM   889  O O   . VAL   A 1 138 ? 0.828   -36.223 -15.255 1.00 44.55 ? 138 VAL   A O   1 
ATOM   890  C CB  . VAL   A 1 138 ? 2.863   -36.001 -13.025 1.00 46.11 ? 138 VAL   A CB  1 
ATOM   891  C CG1 . VAL   A 1 138 ? 4.106   -36.377 -13.818 1.00 43.78 ? 138 VAL   A CG1 1 
ATOM   892  C CG2 . VAL   A 1 138 ? 3.223   -35.586 -11.608 1.00 40.57 ? 138 VAL   A CG2 1 
ATOM   893  N N   . GLY   A 1 139 ? 2.165   -34.644 -16.150 1.00 44.27 ? 139 GLY   A N   1 
ATOM   894  C CA  . GLY   A 1 139 ? 1.793   -34.977 -17.509 1.00 47.03 ? 139 GLY   A CA  1 
ATOM   895  C C   . GLY   A 1 139 ? 0.379   -34.606 -17.880 1.00 44.17 ? 139 GLY   A C   1 
ATOM   896  O O   . GLY   A 1 139 ? -0.120  -35.064 -18.910 1.00 46.28 ? 139 GLY   A O   1 
ATOM   897  N N   . LEU   A 1 140 ? -0.284  -33.786 -17.064 1.00 44.63 ? 140 LEU   A N   1 
ATOM   898  C CA  . LEU   A 1 140 ? -1.665  -33.363 -17.284 1.00 44.97 ? 140 LEU   A CA  1 
ATOM   899  C C   . LEU   A 1 140 ? -2.627  -34.543 -17.399 1.00 46.46 ? 140 LEU   A C   1 
ATOM   900  O O   . LEU   A 1 140 ? -3.692  -34.419 -18.008 1.00 48.57 ? 140 LEU   A O   1 
ATOM   901  C CB  . LEU   A 1 140 ? -1.785  -32.474 -18.527 1.00 42.56 ? 140 LEU   A CB  1 
ATOM   902  C CG  . LEU   A 1 140 ? -0.797  -31.315 -18.676 1.00 44.13 ? 140 LEU   A CG  1 
ATOM   903  C CD1 . LEU   A 1 140 ? -1.121  -30.488 -19.909 1.00 40.85 ? 140 LEU   A CD1 1 
ATOM   904  C CD2 . LEU   A 1 140 ? -0.777  -30.440 -17.429 1.00 37.95 ? 140 LEU   A CD2 1 
ATOM   905  N N   . ALA   A 1 141 ? -2.284  -35.691 -16.815 1.00 45.83 ? 141 ALA   A N   1 
ATOM   906  C CA  . ALA   A 1 141 ? -3.062  -36.905 -17.027 1.00 46.60 ? 141 ALA   A CA  1 
ATOM   907  C C   . ALA   A 1 141 ? -3.813  -37.341 -15.773 1.00 45.32 ? 141 ALA   A C   1 
ATOM   908  O O   . ALA   A 1 141 ? -3.677  -38.485 -15.327 1.00 43.90 ? 141 ALA   A O   1 
ATOM   909  C CB  . ALA   A 1 141 ? -2.143  -38.028 -17.521 1.00 46.42 ? 141 ALA   A CB  1 
ATOM   910  N N   . ASP   A 1 142 ? -4.622  -36.451 -15.203 1.00 44.09 ? 142 ASP   A N   1 
ATOM   911  C CA  . ASP   A 1 142 ? -5.375  -36.815 -14.012 1.00 46.31 ? 142 ASP   A CA  1 
ATOM   912  C C   . ASP   A 1 142 ? -6.491  -35.807 -13.800 1.00 45.76 ? 142 ASP   A C   1 
ATOM   913  O O   . ASP   A 1 142 ? -6.417  -34.666 -14.260 1.00 45.29 ? 142 ASP   A O   1 
ATOM   914  C CB  . ASP   A 1 142 ? -4.475  -36.875 -12.771 1.00 43.67 ? 142 ASP   A CB  1 
ATOM   915  C CG  . ASP   A 1 142 ? -5.161  -37.516 -11.576 1.00 44.02 ? 142 ASP   A CG  1 
ATOM   916  O OD1 . ASP   A 1 142 ? -6.292  -38.019 -11.735 1.00 44.61 ? 142 ASP   A OD1 1 
ATOM   917  O OD2 . ASP   A 1 142 ? -4.567  -37.513 -10.476 1.00 43.76 ? 142 ASP   A OD2 1 
ATOM   918  N N   . TRP   A 1 143 ? -7.532  -36.255 -13.094 1.00 44.60 ? 143 TRP   A N   1 
ATOM   919  C CA  . TRP   A 1 143 ? -8.562  -35.376 -12.555 1.00 43.85 ? 143 TRP   A CA  1 
ATOM   920  C C   . TRP   A 1 143 ? -8.206  -34.852 -11.165 1.00 44.51 ? 143 TRP   A C   1 
ATOM   921  O O   . TRP   A 1 143 ? -9.101  -34.542 -10.369 1.00 43.99 ? 143 TRP   A O   1 
ATOM   922  C CB  . TRP   A 1 143 ? -9.913  -36.089 -12.545 1.00 44.49 ? 143 TRP   A CB  1 
ATOM   923  C CG  . TRP   A 1 143 ? -10.514 -36.172 -13.911 1.00 45.52 ? 143 TRP   A CG  1 
ATOM   924  C CD1 . TRP   A 1 143 ? -10.230 -35.368 -14.976 1.00 46.23 ? 143 TRP   A CD1 1 
ATOM   925  C CD2 . TRP   A 1 143 ? -11.486 -37.120 -14.370 1.00 45.29 ? 143 TRP   A CD2 1 
ATOM   926  N NE1 . TRP   A 1 143 ? -10.971 -35.750 -16.066 1.00 44.62 ? 143 TRP   A NE1 1 
ATOM   927  C CE2 . TRP   A 1 143 ? -11.750 -36.824 -15.721 1.00 45.65 ? 143 TRP   A CE2 1 
ATOM   928  C CE3 . TRP   A 1 143 ? -12.161 -38.187 -13.771 1.00 43.46 ? 143 TRP   A CE3 1 
ATOM   929  C CZ2 . TRP   A 1 143 ? -12.659 -37.556 -16.482 1.00 45.07 ? 143 TRP   A CZ2 1 
ATOM   930  C CZ3 . TRP   A 1 143 ? -13.065 -38.913 -14.531 1.00 47.99 ? 143 TRP   A CZ3 1 
ATOM   931  C CH2 . TRP   A 1 143 ? -13.305 -38.594 -15.869 1.00 45.30 ? 143 TRP   A CH2 1 
ATOM   932  N N   . GLN   A 1 144 ? -6.912  -34.738 -10.866 1.00 46.19 ? 144 GLN   A N   1 
ATOM   933  C CA  . GLN   A 1 144 ? -6.402  -34.042 -9.695  1.00 42.64 ? 144 GLN   A CA  1 
ATOM   934  C C   . GLN   A 1 144 ? -5.298  -33.095 -10.145 1.00 42.29 ? 144 GLN   A C   1 
ATOM   935  O O   . GLN   A 1 144 ? -4.936  -33.047 -11.323 1.00 44.04 ? 144 GLN   A O   1 
ATOM   936  C CB  . GLN   A 1 144 ? -5.875  -35.019 -8.634  1.00 42.34 ? 144 GLN   A CB  1 
ATOM   937  C CG  . GLN   A 1 144 ? -6.858  -36.117 -8.254  1.00 42.31 ? 144 GLN   A CG  1 
ATOM   938  C CD  . GLN   A 1 144 ? -6.328  -37.029 -7.165  1.00 44.88 ? 144 GLN   A CD  1 
ATOM   939  O OE1 . GLN   A 1 144 ? -6.734  -36.932 -6.009  1.00 41.46 ? 144 GLN   A OE1 1 
ATOM   940  N NE2 . GLN   A 1 144 ? -5.414  -37.920 -7.530  1.00 45.98 ? 144 GLN   A NE2 1 
ATOM   941  N N   . SER   A 1 145 ? -4.758  -32.329 -9.196  1.00 43.02 ? 145 SER   A N   1 
ATOM   942  C CA  . SER   A 1 145 ? -3.628  -31.431 -9.448  1.00 43.38 ? 145 SER   A CA  1 
ATOM   943  C C   . SER   A 1 145 ? -2.611  -31.651 -8.333  1.00 41.73 ? 145 SER   A C   1 
ATOM   944  O O   . SER   A 1 145 ? -2.681  -31.010 -7.281  1.00 42.07 ? 145 SER   A O   1 
ATOM   945  C CB  . SER   A 1 145 ? -4.075  -29.977 -9.535  1.00 42.75 ? 145 SER   A CB  1 
ATOM   946  O OG  . SER   A 1 145 ? -4.670  -29.714 -10.793 1.00 43.47 ? 145 SER   A OG  1 
ATOM   947  N N   . VAL   A 1 146 ? -1.673  -32.563 -8.574  1.00 40.72 ? 146 VAL   A N   1 
ATOM   948  C CA  . VAL   A 1 146 ? -0.662  -32.939 -7.590  1.00 39.98 ? 146 VAL   A CA  1 
ATOM   949  C C   . VAL   A 1 146 ? 0.584   -33.399 -8.339  1.00 43.19 ? 146 VAL   A C   1 
ATOM   950  O O   . VAL   A 1 146 ? 0.491   -34.174 -9.297  1.00 43.59 ? 146 VAL   A O   1 
ATOM   951  C CB  . VAL   A 1 146 ? -1.190  -34.029 -6.634  1.00 42.21 ? 146 VAL   A CB  1 
ATOM   952  C CG1 . VAL   A 1 146 ? -1.847  -35.163 -7.418  1.00 37.24 ? 146 VAL   A CG1 1 
ATOM   953  C CG2 . VAL   A 1 146 ? -0.076  -34.555 -5.738  1.00 44.17 ? 146 VAL   A CG2 1 
ATOM   954  N N   . ASN   A 1 147 ? 1.747   -32.908 -7.917  1.00 43.68 ? 147 ASN   A N   1 
ATOM   955  C CA  . ASN   A 1 147 ? 2.999   -33.192 -8.603  1.00 43.96 ? 147 ASN   A CA  1 
ATOM   956  C C   . ASN   A 1 147 ? 4.146   -32.979 -7.622  1.00 43.15 ? 147 ASN   A C   1 
ATOM   957  O O   . ASN   A 1 147 ? 3.996   -32.245 -6.639  1.00 44.59 ? 147 ASN   A O   1 
ATOM   958  C CB  . ASN   A 1 147 ? 3.166   -32.299 -9.846  1.00 43.58 ? 147 ASN   A CB  1 
ATOM   959  C CG  . ASN   A 1 147 ? 3.244   -30.826 -9.498  1.00 44.30 ? 147 ASN   A CG  1 
ATOM   960  O OD1 . ASN   A 1 147 ? 4.314   -30.309 -9.186  1.00 45.06 ? 147 ASN   A OD1 1 
ATOM   961  N ND2 . ASN   A 1 147 ? 2.110   -30.142 -9.556  1.00 41.39 ? 147 ASN   A ND2 1 
ATOM   962  N N   . PRO   A 1 148 ? 5.302   -33.612 -7.859  1.00 43.48 ? 148 PRO   A N   1 
ATOM   963  C CA  . PRO   A 1 148 ? 6.426   -33.476 -6.915  1.00 41.53 ? 148 PRO   A CA  1 
ATOM   964  C C   . PRO   A 1 148 ? 7.122   -32.123 -6.960  1.00 43.25 ? 148 PRO   A C   1 
ATOM   965  O O   . PRO   A 1 148 ? 7.913   -31.831 -6.053  1.00 43.01 ? 148 PRO   A O   1 
ATOM   966  C CB  . PRO   A 1 148 ? 7.381   -34.594 -7.347  1.00 40.10 ? 148 PRO   A CB  1 
ATOM   967  C CG  . PRO   A 1 148 ? 7.067   -34.818 -8.785  1.00 45.42 ? 148 PRO   A CG  1 
ATOM   968  C CD  . PRO   A 1 148 ? 5.589   -34.597 -8.917  1.00 46.48 ? 148 PRO   A CD  1 
ATOM   969  N N   . ASN   A 1 149 ? 6.863   -31.297 -7.977  1.00 42.14 ? 149 ASN   A N   1 
ATOM   970  C CA  . ASN   A 1 149 ? 7.487   -29.980 -8.050  1.00 42.06 ? 149 ASN   A CA  1 
ATOM   971  C C   . ASN   A 1 149 ? 6.829   -28.987 -7.100  1.00 43.07 ? 149 ASN   A C   1 
ATOM   972  O O   . ASN   A 1 149 ? 7.517   -28.171 -6.476  1.00 45.57 ? 149 ASN   A O   1 
ATOM   973  C CB  . ASN   A 1 149 ? 7.426   -29.445 -9.482  1.00 43.58 ? 149 ASN   A CB  1 
ATOM   974  C CG  . ASN   A 1 149 ? 8.237   -30.274 -10.450 1.00 45.07 ? 149 ASN   A CG  1 
ATOM   975  O OD1 . ASN   A 1 149 ? 9.103   -31.044 -10.043 1.00 45.53 ? 149 ASN   A OD1 1 
ATOM   976  N ND2 . ASN   A 1 149 ? 7.970   -30.110 -11.743 1.00 42.27 ? 149 ASN   A ND2 1 
ATOM   977  N N   . TYR   A 1 150 ? 5.504   -29.038 -6.978  1.00 42.29 ? 150 TYR   A N   1 
ATOM   978  C CA  . TYR   A 1 150 ? 4.758   -28.026 -6.245  1.00 42.54 ? 150 TYR   A CA  1 
ATOM   979  C C   . TYR   A 1 150 ? 3.878   -28.570 -5.134  1.00 44.08 ? 150 TYR   A C   1 
ATOM   980  O O   . TYR   A 1 150 ? 3.511   -27.799 -4.239  1.00 44.46 ? 150 TYR   A O   1 
ATOM   981  C CB  . TYR   A 1 150 ? 3.873   -27.219 -7.204  1.00 43.08 ? 150 TYR   A CB  1 
ATOM   982  C CG  . TYR   A 1 150 ? 4.591   -26.744 -8.442  1.00 43.47 ? 150 TYR   A CG  1 
ATOM   983  C CD1 . TYR   A 1 150 ? 5.564   -25.759 -8.366  1.00 43.86 ? 150 TYR   A CD1 1 
ATOM   984  C CD2 . TYR   A 1 150 ? 4.286   -27.271 -9.689  1.00 44.56 ? 150 TYR   A CD2 1 
ATOM   985  C CE1 . TYR   A 1 150 ? 6.221   -25.319 -9.497  1.00 40.73 ? 150 TYR   A CE1 1 
ATOM   986  C CE2 . TYR   A 1 150 ? 4.939   -26.840 -10.824 1.00 43.11 ? 150 TYR   A CE2 1 
ATOM   987  C CZ  . TYR   A 1 150 ? 5.905   -25.866 -10.723 1.00 45.39 ? 150 TYR   A CZ  1 
ATOM   988  O OH  . TYR   A 1 150 ? 6.557   -25.431 -11.852 1.00 46.78 ? 150 TYR   A OH  1 
ATOM   989  N N   . GLY   A 1 151 ? 3.518   -29.847 -5.155  1.00 43.91 ? 151 GLY   A N   1 
ATOM   990  C CA  . GLY   A 1 151 ? 2.624   -30.376 -4.147  1.00 41.30 ? 151 GLY   A CA  1 
ATOM   991  C C   . GLY   A 1 151 ? 1.215   -30.571 -4.665  1.00 42.98 ? 151 GLY   A C   1 
ATOM   992  O O   . GLY   A 1 151 ? 1.012   -30.774 -5.865  1.00 44.62 ? 151 GLY   A O   1 
ATOM   993  N N   . ARG   A 1 152 ? 0.229   -30.495 -3.778  1.00 40.52 ? 152 ARG   A N   1 
ATOM   994  C CA  . ARG   A 1 152 ? -1.146  -30.836 -4.107  1.00 42.25 ? 152 ARG   A CA  1 
ATOM   995  C C   . ARG   A 1 152 ? -2.047  -29.618 -3.953  1.00 39.40 ? 152 ARG   A C   1 
ATOM   996  O O   . ARG   A 1 152 ? -1.849  -28.796 -3.052  1.00 40.41 ? 152 ARG   A O   1 
ATOM   997  C CB  . ARG   A 1 152 ? -1.638  -31.976 -3.210  1.00 38.17 ? 152 ARG   A CB  1 
ATOM   998  C CG  . ARG   A 1 152 ? -2.941  -32.628 -3.630  1.00 40.32 ? 152 ARG   A CG  1 
ATOM   999  C CD  . ARG   A 1 152 ? -3.379  -33.613 -2.563  1.00 39.69 ? 152 ARG   A CD  1 
ATOM   1000 N NE  . ARG   A 1 152 ? -3.658  -32.930 -1.305  1.00 41.29 ? 152 ARG   A NE  1 
ATOM   1001 C CZ  . ARG   A 1 152 ? -3.852  -33.539 -0.144  1.00 41.55 ? 152 ARG   A CZ  1 
ATOM   1002 N NH1 . ARG   A 1 152 ? -3.773  -34.855 -0.032  1.00 40.69 ? 152 ARG   A NH1 1 
ATOM   1003 N NH2 . ARG   A 1 152 ? -4.127  -32.809 0.933   1.00 39.50 ? 152 ARG   A NH2 1 
ATOM   1004 N N   . THR   A 1 153 ? -3.035  -29.509 -4.841  1.00 39.11 ? 153 THR   A N   1 
ATOM   1005 C CA  . THR   A 1 153 ? -4.061  -28.476 -4.767  1.00 39.69 ? 153 THR   A CA  1 
ATOM   1006 C C   . THR   A 1 153 ? -5.310  -29.057 -4.115  1.00 36.95 ? 153 THR   A C   1 
ATOM   1007 O O   . THR   A 1 153 ? -5.751  -30.154 -4.475  1.00 38.86 ? 153 THR   A O   1 
ATOM   1008 C CB  . THR   A 1 153 ? -4.401  -27.931 -6.156  1.00 40.34 ? 153 THR   A CB  1 
ATOM   1009 O OG1 . THR   A 1 153 ? -3.206  -27.480 -6.802  1.00 38.17 ? 153 THR   A OG1 1 
ATOM   1010 C CG2 . THR   A 1 153 ? -5.379  -26.767 -6.049  1.00 37.96 ? 153 THR   A CG2 1 
ATOM   1011 N N   . ASN   A 1 154 ? -5.875  -28.319 -3.162  1.00 39.82 ? 154 ASN   A N   1 
ATOM   1012 C CA  . ASN   A 1 154 ? -7.013  -28.772 -2.377  1.00 40.09 ? 154 ASN   A CA  1 
ATOM   1013 C C   . ASN   A 1 154 ? -8.249  -27.957 -2.736  1.00 41.13 ? 154 ASN   A C   1 
ATOM   1014 O O   . ASN   A 1 154 ? -8.164  -26.742 -2.938  1.00 45.21 ? 154 ASN   A O   1 
ATOM   1015 C CB  . ASN   A 1 154 ? -6.717  -28.650 -0.881  1.00 40.91 ? 154 ASN   A CB  1 
ATOM   1016 C CG  . ASN   A 1 154 ? -5.458  -29.388 -0.475  1.00 39.70 ? 154 ASN   A CG  1 
ATOM   1017 O OD1 . ASN   A 1 154 ? -5.305  -30.575 -0.757  1.00 40.28 ? 154 ASN   A OD1 1 
ATOM   1018 N ND2 . ASN   A 1 154 ? -4.539  -28.682 0.177   1.00 37.43 ? 154 ASN   A ND2 1 
ATOM   1019 N N   . ASN   A 1 155 ? -9.392  -28.634 -2.819  1.00 41.49 ? 155 ASN   A N   1 
ATOM   1020 C CA  . ASN   A 1 155 ? -10.641 -27.971 -3.176  1.00 38.44 ? 155 ASN   A CA  1 
ATOM   1021 C C   . ASN   A 1 155 ? -10.978 -26.902 -2.138  1.00 42.36 ? 155 ASN   A C   1 
ATOM   1022 O O   . ASN   A 1 155 ? -11.010 -27.201 -0.937  1.00 43.40 ? 155 ASN   A O   1 
ATOM   1023 C CB  . ASN   A 1 155 ? -11.778 -28.992 -3.278  1.00 38.36 ? 155 ASN   A CB  1 
ATOM   1024 C CG  . ASN   A 1 155 ? -13.028 -28.427 -3.945  1.00 40.55 ? 155 ASN   A CG  1 
ATOM   1025 O OD1 . ASN   A 1 155 ? -13.534 -27.372 -3.565  1.00 38.70 ? 155 ASN   A OD1 1 
ATOM   1026 N ND2 . ASN   A 1 155 ? -13.531 -29.138 -4.947  1.00 39.24 ? 155 ASN   A ND2 1 
ATOM   1027 N N   . PRO   A 1 156 ? -11.224 -25.656 -2.553  1.00 43.63 ? 156 PRO   A N   1 
ATOM   1028 C CA  . PRO   A 1 156 ? -11.544 -24.605 -1.572  1.00 44.35 ? 156 PRO   A CA  1 
ATOM   1029 C C   . PRO   A 1 156 ? -12.828 -24.855 -0.798  1.00 43.73 ? 156 PRO   A C   1 
ATOM   1030 O O   . PRO   A 1 156 ? -12.974 -24.324 0.310   1.00 50.06 ? 156 PRO   A O   1 
ATOM   1031 C CB  . PRO   A 1 156 ? -11.649 -23.340 -2.436  1.00 43.71 ? 156 PRO   A CB  1 
ATOM   1032 C CG  . PRO   A 1 156 ? -10.861 -23.656 -3.666  1.00 42.00 ? 156 PRO   A CG  1 
ATOM   1033 C CD  . PRO   A 1 156 ? -11.078 -25.116 -3.913  1.00 40.32 ? 156 PRO   A CD  1 
ATOM   1034 N N   . HIS   A 1 157 ? -13.765 -25.637 -1.339  1.00 43.40 ? 157 HIS   A N   1 
ATOM   1035 C CA  . HIS   A 1 157 ? -14.988 -25.953 -0.611  1.00 43.73 ? 157 HIS   A CA  1 
ATOM   1036 C C   . HIS   A 1 157 ? -14.800 -27.089 0.386   1.00 44.98 ? 157 HIS   A C   1 
ATOM   1037 O O   . HIS   A 1 157 ? -15.620 -27.238 1.298   1.00 47.21 ? 157 HIS   A O   1 
ATOM   1038 C CB  . HIS   A 1 157 ? -16.101 -26.312 -1.595  1.00 47.27 ? 157 HIS   A CB  1 
ATOM   1039 C CG  . HIS   A 1 157 ? -16.344 -25.266 -2.640  1.00 46.21 ? 157 HIS   A CG  1 
ATOM   1040 N ND1 . HIS   A 1 157 ? -17.322 -24.301 -2.519  1.00 46.82 ? 157 HIS   A ND1 1 
ATOM   1041 C CD2 . HIS   A 1 157 ? -15.724 -25.025 -3.818  1.00 42.26 ? 157 HIS   A CD2 1 
ATOM   1042 C CE1 . HIS   A 1 157 ? -17.297 -23.514 -3.580  1.00 42.13 ? 157 HIS   A CE1 1 
ATOM   1043 N NE2 . HIS   A 1 157 ? -16.336 -23.932 -4.384  1.00 45.36 ? 157 HIS   A NE2 1 
ATOM   1044 N N   . ASP   A 1 158 ? -13.739 -27.882 0.233   1.00 44.14 ? 158 ASP   A N   1 
ATOM   1045 C CA  . ASP   A 1 158 ? -13.427 -28.996 1.119   1.00 46.19 ? 158 ASP   A CA  1 
ATOM   1046 C C   . ASP   A 1 158 ? -11.997 -29.441 0.845   1.00 46.29 ? 158 ASP   A C   1 
ATOM   1047 O O   . ASP   A 1 158 ? -11.729 -30.100 -0.163  1.00 42.94 ? 158 ASP   A O   1 
ATOM   1048 C CB  . ASP   A 1 158 ? -14.416 -30.150 0.915   1.00 47.44 ? 158 ASP   A CB  1 
ATOM   1049 C CG  . ASP   A 1 158 ? -14.304 -31.226 1.988   1.00 47.07 ? 158 ASP   A CG  1 
ATOM   1050 O OD1 . ASP   A 1 158 ? -13.232 -31.355 2.618   1.00 46.06 ? 158 ASP   A OD1 1 
ATOM   1051 O OD2 . ASP   A 1 158 ? -15.297 -31.954 2.196   1.00 49.11 ? 158 ASP   A OD2 1 
ATOM   1052 N N   . HIS   A 1 159 ? -11.072 -29.080 1.738   1.00 43.68 ? 159 HIS   A N   1 
ATOM   1053 C CA  . HIS   A 1 159 ? -9.655  -29.358 1.526   1.00 44.85 ? 159 HIS   A CA  1 
ATOM   1054 C C   . HIS   A 1 159 ? -9.337  -30.849 1.481   1.00 46.99 ? 159 HIS   A C   1 
ATOM   1055 O O   . HIS   A 1 159 ? -8.214  -31.213 1.112   1.00 44.41 ? 159 HIS   A O   1 
ATOM   1056 C CB  . HIS   A 1 159 ? -8.829  -28.677 2.620   1.00 43.79 ? 159 HIS   A CB  1 
ATOM   1057 C CG  . HIS   A 1 159 ? -8.993  -27.188 2.661   1.00 47.87 ? 159 HIS   A CG  1 
ATOM   1058 N ND1 . HIS   A 1 159 ? -8.766  -26.444 3.799   1.00 44.51 ? 159 HIS   A ND1 1 
ATOM   1059 C CD2 . HIS   A 1 159 ? -9.362  -26.305 1.702   1.00 43.33 ? 159 HIS   A CD2 1 
ATOM   1060 C CE1 . HIS   A 1 159 ? -8.986  -25.168 3.539   1.00 47.27 ? 159 HIS   A CE1 1 
ATOM   1061 N NE2 . HIS   A 1 159 ? -9.350  -25.057 2.274   1.00 46.11 ? 159 HIS   A NE2 1 
ATOM   1062 N N   . SER   A 1 160 ? -10.285 -31.714 1.840   1.00 43.88 ? 160 SER   A N   1 
ATOM   1063 C CA  . SER   A 1 160 ? -10.072 -33.153 1.766   1.00 45.72 ? 160 SER   A CA  1 
ATOM   1064 C C   . SER   A 1 160 ? -10.364 -33.728 0.386   1.00 47.72 ? 160 SER   A C   1 
ATOM   1065 O O   . SER   A 1 160 ? -10.130 -34.923 0.172   1.00 49.07 ? 160 SER   A O   1 
ATOM   1066 C CB  . SER   A 1 160 ? -10.942 -33.869 2.805   1.00 45.39 ? 160 SER   A CB  1 
ATOM   1067 O OG  . SER   A 1 160 ? -12.319 -33.709 2.516   1.00 45.06 ? 160 SER   A OG  1 
ATOM   1068 N N   . ARG   A 1 161 ? -10.861 -32.919 -0.547  1.00 43.79 ? 161 ARG   A N   1 
ATOM   1069 C CA  . ARG   A 1 161 ? -11.292 -33.392 -1.853  1.00 44.44 ? 161 ARG   A CA  1 
ATOM   1070 C C   . ARG   A 1 161 ? -10.416 -32.798 -2.949  1.00 43.15 ? 161 ARG   A C   1 
ATOM   1071 O O   . ARG   A 1 161 ? -9.811  -31.736 -2.776  1.00 40.46 ? 161 ARG   A O   1 
ATOM   1072 C CB  . ARG   A 1 161 ? -12.760 -33.028 -2.115  1.00 44.46 ? 161 ARG   A CB  1 
ATOM   1073 C CG  . ARG   A 1 161 ? -13.658 -33.130 -0.895  1.00 47.49 ? 161 ARG   A CG  1 
ATOM   1074 C CD  . ARG   A 1 161 ? -13.773 -34.553 -0.382  1.00 48.52 ? 161 ARG   A CD  1 
ATOM   1075 N NE  . ARG   A 1 161 ? -14.523 -35.411 -1.291  1.00 50.63 ? 161 ARG   A NE  1 
ATOM   1076 C CZ  . ARG   A 1 161 ? -14.946 -36.631 -0.989  1.00 49.79 ? 161 ARG   A CZ  1 
ATOM   1077 N NH1 . ARG   A 1 161 ? -14.719 -37.166 0.200   1.00 49.87 ? 161 ARG   A NH1 1 
ATOM   1078 N NH2 . ARG   A 1 161 ? -15.615 -37.330 -1.901  1.00 46.19 ? 161 ARG   A NH2 1 
ATOM   1079 N N   . SER   A 1 162 ? -10.434 -33.445 -4.115  1.00 41.50 ? 162 SER   A N   1 
ATOM   1080 C CA  . SER   A 1 162 ? -9.615  -32.975 -5.261  1.00 40.87 ? 162 SER   A CA  1 
ATOM   1081 C C   . SER   A 1 162 ? -10.221 -31.735 -5.925  1.00 39.44 ? 162 SER   A C   1 
ATOM   1082 O O   . SER   A 1 162 ? -11.454 -31.695 -6.086  1.00 39.25 ? 162 SER   A O   1 
ATOM   1083 C CB  . SER   A 1 162 ? -9.438  -34.073 -6.280  1.00 41.20 ? 162 SER   A CB  1 
ATOM   1084 O OG  . SER   A 1 162 ? -9.244  -33.539 -7.583  1.00 40.54 ? 162 SER   A OG  1 
ATOM   1085 N N   . ALA   A 1 163 ? -9.388  -30.750 -6.253  1.00 37.68 ? 163 ALA   A N   1 
ATOM   1086 C CA  . ALA   A 1 163 ? -9.822  -29.561 -7.020  1.00 39.20 ? 163 ALA   A CA  1 
ATOM   1087 C C   . ALA   A 1 163 ? -9.357  -29.779 -8.451  1.00 42.67 ? 163 ALA   A C   1 
ATOM   1088 O O   . ALA   A 1 163 ? -9.589  -28.864 -9.252  1.00 44.93 ? 163 ALA   A O   1 
ATOM   1089 C CB  . ALA   A 1 163 ? -9.159  -28.348 -6.435  1.00 36.48 ? 163 ALA   A CB  1 
ATOM   1090 N N   . GLY   A 1 164 ? -8.886  -30.979 -8.796  1.00 40.20 ? 164 GLY   A N   1 
ATOM   1091 C CA  . GLY   A 1 164 ? -8.148  -31.266 -10.043 1.00 41.80 ? 164 GLY   A CA  1 
ATOM   1092 C C   . GLY   A 1 164 ? -8.930  -31.526 -11.300 1.00 45.49 ? 164 GLY   A C   1 
ATOM   1093 O O   . GLY   A 1 164 ? -10.137 -31.216 -11.314 1.00 39.81 ? 164 GLY   A O   1 
ATOM   1094 N N   . GLY   A 1 165 ? -8.279  -32.109 -12.311 1.00 45.90 ? 165 GLY   A N   1 
ATOM   1095 C CA  . GLY   A 1 165 ? -8.847  -32.241 -13.664 1.00 46.40 ? 165 GLY   A CA  1 
ATOM   1096 C C   . GLY   A 1 165 ? -7.767  -31.727 -14.579 1.00 48.81 ? 165 GLY   A C   1 
ATOM   1097 O O   . GLY   A 1 165 ? -7.953  -31.882 -15.789 1.00 48.84 ? 165 GLY   A O   1 
ATOM   1098 N N   . SER   A 1 166 ? -6.675  -31.203 -14.012 1.00 51.91 ? 166 SER   A N   1 
ATOM   1099 C CA  . SER   A 1 166 ? -5.461  -30.688 -14.711 1.00 42.55 ? 166 SER   A CA  1 
ATOM   1100 C C   . SER   A 1 166 ? -5.544  -29.170 -14.869 1.00 40.89 ? 166 SER   A C   1 
ATOM   1101 O O   . SER   A 1 166 ? -4.483  -28.552 -14.889 1.00 43.97 ? 166 SER   A O   1 
ATOM   1102 C CB  . SER   A 1 166 ? -5.158  -31.395 -16.025 1.00 47.11 ? 166 SER   A CB  1 
ATOM   1103 O OG  . SER   A 1 166 ? -5.362  -30.540 -17.138 1.00 51.19 ? 166 SER   A OG  1 
ATOM   1104 N N   . SER   A 1 167 ? -6.724  -28.584 -14.740 1.00 38.19 ? 167 SER   A N   1 
ATOM   1105 C CA  . SER   A 1 167 ? -6.837  -27.105 -14.698 1.00 42.79 ? 167 SER   A CA  1 
ATOM   1106 C C   . SER   A 1 167 ? -7.260  -26.770 -13.265 1.00 42.60 ? 167 SER   A C   1 
ATOM   1107 O O   . SER   A 1 167 ? -7.829  -25.692 -13.052 1.00 41.21 ? 167 SER   A O   1 
ATOM   1108 C CB  . SER   A 1 167 ? -7.755  -26.546 -15.746 1.00 42.19 ? 167 SER   A CB  1 
ATOM   1109 O OG  . SER   A 1 167 ? -7.342  -26.946 -17.045 1.00 40.01 ? 167 SER   A OG  1 
ATOM   1110 N N   . GLY   A 1 168 ? -7.102  -27.730 -12.351 1.00 40.91 ? 168 GLY   A N   1 
ATOM   1111 C CA  . GLY   A 1 168 ? -7.595  -27.535 -10.977 1.00 41.49 ? 168 GLY   A CA  1 
ATOM   1112 C C   . GLY   A 1 168 ? -6.930  -26.390 -10.258 1.00 40.48 ? 168 GLY   A C   1 
ATOM   1113 O O   . GLY   A 1 168 ? -7.651  -25.647 -9.571  1.00 40.65 ? 168 GLY   A O   1 
ATOM   1114 N N   . GLY   A 1 169 ? -5.617  -26.232 -10.408 1.00 39.75 ? 169 GLY   A N   1 
ATOM   1115 C CA  . GLY   A 1 169 ? -4.980  -25.048 -9.811  1.00 38.85 ? 169 GLY   A CA  1 
ATOM   1116 C C   . GLY   A 1 169 ? -5.703  -23.821 -10.315 1.00 42.03 ? 169 GLY   A C   1 
ATOM   1117 O O   . GLY   A 1 169 ? -5.929  -22.892 -9.519  1.00 42.24 ? 169 GLY   A O   1 
ATOM   1118 N N   . ALA   A 1 170 ? -6.087  -23.838 -11.592 1.00 41.22 ? 170 ALA   A N   1 
ATOM   1119 C CA  . ALA   A 1 170 ? -6.772  -22.693 -12.184 1.00 39.70 ? 170 ALA   A CA  1 
ATOM   1120 C C   . ALA   A 1 170 ? -8.157  -22.510 -11.573 1.00 39.84 ? 170 ALA   A C   1 
ATOM   1121 O O   . ALA   A 1 170 ? -8.550  -21.393 -11.211 1.00 42.55 ? 170 ALA   A O   1 
ATOM   1122 C CB  . ALA   A 1 170 ? -6.867  -22.870 -13.699 1.00 40.15 ? 170 ALA   A CB  1 
ATOM   1123 N N   . ALA   A 1 171 ? -8.909  -23.607 -11.446 1.00 38.42 ? 171 ALA   A N   1 
ATOM   1124 C CA  . ALA   A 1 171 ? -10.260 -23.539 -10.900 1.00 37.02 ? 171 ALA   A CA  1 
ATOM   1125 C C   . ALA   A 1 171 ? -10.258 -23.218 -9.412  1.00 40.60 ? 171 ALA   A C   1 
ATOM   1126 O O   . ALA   A 1 171 ? -11.163 -22.530 -8.927  1.00 39.92 ? 171 ALA   A O   1 
ATOM   1127 C CB  . ALA   A 1 171 ? -10.990 -24.856 -11.159 1.00 36.52 ? 171 ALA   A CB  1 
ATOM   1128 N N   . ALA   A 1 172 ? -9.263  -23.710 -8.672  1.00 39.30 ? 172 ALA   A N   1 
ATOM   1129 C CA  . ALA   A 1 172 ? -9.188  -23.413 -7.246  1.00 38.35 ? 172 ALA   A CA  1 
ATOM   1130 C C   . ALA   A 1 172 ? -8.893  -21.938 -7.006  1.00 40.50 ? 172 ALA   A C   1 
ATOM   1131 O O   . ALA   A 1 172 ? -9.444  -21.331 -6.081  1.00 41.54 ? 172 ALA   A O   1 
ATOM   1132 C CB  . ALA   A 1 172 ? -8.125  -24.288 -6.582  1.00 37.23 ? 172 ALA   A CB  1 
ATOM   1133 N N   . ALA   A 1 173 ? -8.032  -21.345 -7.836  1.00 42.35 ? 173 ALA   A N   1 
ATOM   1134 C CA  . ALA   A 1 173 ? -7.724  -19.925 -7.699  1.00 41.46 ? 173 ALA   A CA  1 
ATOM   1135 C C   . ALA   A 1 173 ? -8.953  -19.068 -7.970  1.00 42.73 ? 173 ALA   A C   1 
ATOM   1136 O O   . ALA   A 1 173 ? -9.149  -18.031 -7.327  1.00 39.57 ? 173 ALA   A O   1 
ATOM   1137 C CB  . ALA   A 1 173 ? -6.584  -19.544 -8.643  1.00 37.96 ? 173 ALA   A CB  1 
ATOM   1138 N N   . LEU   A 1 174 ? -9.792  -19.484 -8.922  1.00 38.23 ? 174 LEU   A N   1 
ATOM   1139 C CA  . LEU   A 1 174 ? -11.017 -18.744 -9.206  1.00 39.15 ? 174 LEU   A CA  1 
ATOM   1140 C C   . LEU   A 1 174 ? -12.038 -18.917 -8.089  1.00 40.82 ? 174 LEU   A C   1 
ATOM   1141 O O   . LEU   A 1 174 ? -12.690 -17.948 -7.682  1.00 39.21 ? 174 LEU   A O   1 
ATOM   1142 C CB  . LEU   A 1 174 ? -11.603 -19.196 -10.543 1.00 40.91 ? 174 LEU   A CB  1 
ATOM   1143 C CG  . LEU   A 1 174 ? -10.860 -18.738 -11.797 1.00 40.77 ? 174 LEU   A CG  1 
ATOM   1144 C CD1 . LEU   A 1 174 ? -11.240 -19.615 -12.977 1.00 42.06 ? 174 LEU   A CD1 1 
ATOM   1145 C CD2 . LEU   A 1 174 ? -11.176 -17.284 -12.097 1.00 39.82 ? 174 LEU   A CD2 1 
ATOM   1146 N N   . ALA   A 1 175 ? -12.196 -20.145 -7.589  1.00 40.90 ? 175 ALA   A N   1 
ATOM   1147 C CA  . ALA   A 1 175 ? -13.141 -20.392 -6.505  1.00 39.90 ? 175 ALA   A CA  1 
ATOM   1148 C C   . ALA   A 1 175 ? -12.714 -19.704 -5.215  1.00 43.69 ? 175 ALA   A C   1 
ATOM   1149 O O   . ALA   A 1 175 ? -13.567 -19.311 -4.412  1.00 42.97 ? 175 ALA   A O   1 
ATOM   1150 C CB  . ALA   A 1 175 ? -13.298 -21.896 -6.279  1.00 38.68 ? 175 ALA   A CB  1 
ATOM   1151 N N   . ALA   A 1 176 ? -11.411 -19.547 -4.999  1.00 44.32 ? 176 ALA   A N   1 
ATOM   1152 C CA  . ALA   A 1 176 ? -10.915 -18.865 -3.812  1.00 43.66 ? 176 ALA   A CA  1 
ATOM   1153 C C   . ALA   A 1 176 ? -10.867 -17.352 -3.975  1.00 47.16 ? 176 ALA   A C   1 
ATOM   1154 O O   . ALA   A 1 176 ? -10.512 -16.654 -3.019  1.00 51.03 ? 176 ALA   A O   1 
ATOM   1155 C CB  . ALA   A 1 176 ? -9.525  -19.390 -3.444  1.00 44.45 ? 176 ALA   A CB  1 
ATOM   1156 N N   . GLY   A 1 177 ? -11.208 -16.833 -5.152  1.00 44.73 ? 177 GLY   A N   1 
ATOM   1157 C CA  . GLY   A 1 177 ? -11.231 -15.404 -5.380  1.00 44.43 ? 177 GLY   A CA  1 
ATOM   1158 C C   . GLY   A 1 177 ? -9.879  -14.751 -5.548  1.00 44.02 ? 177 GLY   A C   1 
ATOM   1159 O O   . GLY   A 1 177 ? -9.788  -13.522 -5.444  1.00 44.68 ? 177 GLY   A O   1 
ATOM   1160 N N   . MET   A 1 178 ? -8.825  -15.525 -5.808  1.00 43.36 ? 178 MET   A N   1 
ATOM   1161 C CA  . MET   A 1 178 ? -7.496  -14.938 -5.936  1.00 43.63 ? 178 MET   A CA  1 
ATOM   1162 C C   . MET   A 1 178 ? -7.380  -14.110 -7.211  1.00 46.45 ? 178 MET   A C   1 
ATOM   1163 O O   . MET   A 1 178 ? -6.874  -12.983 -7.187  1.00 43.96 ? 178 MET   A O   1 
ATOM   1164 C CB  . MET   A 1 178 ? -6.431  -16.033 -5.908  1.00 42.37 ? 178 MET   A CB  1 
ATOM   1165 C CG  . MET   A 1 178 ? -6.565  -16.994 -4.740  1.00 41.98 ? 178 MET   A CG  1 
ATOM   1166 S SD  . MET   A 1 178 ? -5.220  -18.195 -4.681  1.00 44.86 ? 178 MET   A SD  1 
ATOM   1167 C CE  . MET   A 1 178 ? -5.857  -19.356 -3.478  1.00 43.95 ? 178 MET   A CE  1 
ATOM   1168 N N   . VAL   A 1 179 ? -7.834  -14.653 -8.336  1.00 44.87 ? 179 VAL   A N   1 
ATOM   1169 C CA  . VAL   A 1 179 ? -7.774  -13.955 -9.619  1.00 44.26 ? 179 VAL   A CA  1 
ATOM   1170 C C   . VAL   A 1 179 ? -9.125  -14.074 -10.316 1.00 43.77 ? 179 VAL   A C   1 
ATOM   1171 O O   . VAL   A 1 179 ? -9.843  -15.063 -10.106 1.00 44.23 ? 179 VAL   A O   1 
ATOM   1172 C CB  . VAL   A 1 179 ? -6.637  -14.503 -10.498 1.00 47.96 ? 179 VAL   A CB  1 
ATOM   1173 C CG1 . VAL   A 1 179 ? -5.287  -14.033 -9.970  1.00 48.05 ? 179 VAL   A CG1 1 
ATOM   1174 C CG2 . VAL   A 1 179 ? -6.690  -16.023 -10.547 1.00 46.77 ? 179 VAL   A CG2 1 
ATOM   1175 N N   . PRO   A 1 180 ? -9.522  -13.094 -11.133 1.00 44.36 ? 180 PRO   A N   1 
ATOM   1176 C CA  . PRO   A 1 180 ? -10.835 -13.151 -11.787 1.00 45.40 ? 180 PRO   A CA  1 
ATOM   1177 C C   . PRO   A 1 180 ? -10.884 -13.904 -13.108 1.00 43.53 ? 180 PRO   A C   1 
ATOM   1178 O O   . PRO   A 1 180 ? -11.987 -14.078 -13.646 1.00 45.52 ? 180 PRO   A O   1 
ATOM   1179 C CB  . PRO   A 1 180 ? -11.156 -11.664 -12.008 1.00 47.47 ? 180 PRO   A CB  1 
ATOM   1180 C CG  . PRO   A 1 180 ? -9.817  -11.035 -12.210 1.00 46.04 ? 180 PRO   A CG  1 
ATOM   1181 C CD  . PRO   A 1 180 ? -8.873  -11.781 -11.305 1.00 44.17 ? 180 PRO   A CD  1 
ATOM   1182 N N   . LEU   A 1 181 ? -9.752  -14.355 -13.644 1.00 44.16 ? 181 LEU   A N   1 
ATOM   1183 C CA  . LEU   A 1 181 ? -9.742  -14.987 -14.956 1.00 45.72 ? 181 LEU   A CA  1 
ATOM   1184 C C   . LEU   A 1 181 ? -8.600  -15.988 -15.031 1.00 45.63 ? 181 LEU   A C   1 
ATOM   1185 O O   . LEU   A 1 181 ? -7.546  -15.798 -14.417 1.00 46.93 ? 181 LEU   A O   1 
ATOM   1186 C CB  . LEU   A 1 181 ? -9.609  -13.945 -16.072 1.00 43.66 ? 181 LEU   A CB  1 
ATOM   1187 C CG  . LEU   A 1 181 ? -9.630  -14.421 -17.525 1.00 45.05 ? 181 LEU   A CG  1 
ATOM   1188 C CD1 . LEU   A 1 181 ? -11.002 -14.950 -17.912 1.00 42.44 ? 181 LEU   A CD1 1 
ATOM   1189 C CD2 . LEU   A 1 181 ? -9.197  -13.295 -18.450 1.00 38.97 ? 181 LEU   A CD2 1 
ATOM   1190 N N   . GLU   A 1 182 ? -8.819  -17.056 -15.796 1.00 43.61 ? 182 GLU   A N   1 
ATOM   1191 C CA  . GLU   A 1 182 ? -7.814  -18.090 -15.989 1.00 43.01 ? 182 GLU   A CA  1 
ATOM   1192 C C   . GLU   A 1 182 ? -8.015  -18.717 -17.365 1.00 40.31 ? 182 GLU   A C   1 
ATOM   1193 O O   . GLU   A 1 182 ? -8.949  -18.377 -18.095 1.00 39.03 ? 182 GLU   A O   1 
ATOM   1194 C CB  . GLU   A 1 182 ? -7.880  -19.133 -14.868 1.00 43.25 ? 182 GLU   A CB  1 
ATOM   1195 C CG  . GLU   A 1 182 ? -6.674  -19.131 -13.938 1.00 45.09 ? 182 GLU   A CG  1 
ATOM   1196 C CD  . GLU   A 1 182 ? -5.513  -19.925 -14.492 1.00 46.72 ? 182 GLU   A CD  1 
ATOM   1197 O OE1 . GLU   A 1 182 ? -5.583  -20.336 -15.666 1.00 48.89 ? 182 GLU   A OE1 1 
ATOM   1198 O OE2 . GLU   A 1 182 ? -4.537  -20.154 -13.751 1.00 45.83 ? 182 GLU   A OE2 1 
ATOM   1199 N N   . TYR   A 1 183 ? -7.121  -19.641 -17.715 1.00 37.41 ? 183 TYR   A N   1 
ATOM   1200 C CA  . TYR   A 1 183 ? -7.141  -20.299 -19.017 1.00 42.00 ? 183 TYR   A CA  1 
ATOM   1201 C C   . TYR   A 1 183 ? -6.516  -21.677 -18.871 1.00 40.44 ? 183 TYR   A C   1 
ATOM   1202 O O   . TYR   A 1 183 ? -5.412  -21.799 -18.333 1.00 40.69 ? 183 TYR   A O   1 
ATOM   1203 C CB  . TYR   A 1 183 ? -6.373  -19.483 -20.064 1.00 38.99 ? 183 TYR   A CB  1 
ATOM   1204 C CG  . TYR   A 1 183 ? -7.025  -19.447 -21.429 1.00 40.94 ? 183 TYR   A CG  1 
ATOM   1205 C CD1 . TYR   A 1 183 ? -6.801  -20.451 -22.364 1.00 39.79 ? 183 TYR   A CD1 1 
ATOM   1206 C CD2 . TYR   A 1 183 ? -7.861  -18.400 -21.782 1.00 39.96 ? 183 TYR   A CD2 1 
ATOM   1207 C CE1 . TYR   A 1 183 ? -7.399  -20.410 -23.611 1.00 36.96 ? 183 TYR   A CE1 1 
ATOM   1208 C CE2 . TYR   A 1 183 ? -8.460  -18.348 -23.022 1.00 39.43 ? 183 TYR   A CE2 1 
ATOM   1209 C CZ  . TYR   A 1 183 ? -8.229  -19.354 -23.932 1.00 38.55 ? 183 TYR   A CZ  1 
ATOM   1210 O OH  . TYR   A 1 183 ? -8.833  -19.299 -25.167 1.00 39.80 ? 183 TYR   A OH  1 
ATOM   1211 N N   . GLY   A 1 184 ? -7.216  -22.706 -19.352 1.00 37.40 ? 184 GLY   A N   1 
ATOM   1212 C CA  . GLY   A 1 184 ? -6.748  -24.070 -19.271 1.00 37.49 ? 184 GLY   A CA  1 
ATOM   1213 C C   . GLY   A 1 184 ? -6.779  -24.781 -20.614 1.00 41.21 ? 184 GLY   A C   1 
ATOM   1214 O O   . GLY   A 1 184 ? -7.128  -24.207 -21.647 1.00 39.56 ? 184 GLY   A O   1 
ATOM   1215 N N   . SER   A 1 185 ? -6.383  -26.049 -20.574 1.00 40.95 ? 185 SER   A N   1 
ATOM   1216 C CA  . SER   A 1 185 ? -6.459  -26.951 -21.711 1.00 42.21 ? 185 SER   A CA  1 
ATOM   1217 C C   . SER   A 1 185 ? -7.443  -28.062 -21.376 1.00 43.83 ? 185 SER   A C   1 
ATOM   1218 O O   . SER   A 1 185 ? -7.881  -28.197 -20.234 1.00 39.22 ? 185 SER   A O   1 
ATOM   1219 C CB  . SER   A 1 185 ? -5.080  -27.527 -22.058 1.00 43.15 ? 185 SER   A CB  1 
ATOM   1220 O OG  . SER   A 1 185 ? -4.471  -28.124 -20.926 1.00 44.07 ? 185 SER   A OG  1 
ATOM   1221 N N   . ASP   A 1 186 ? -7.801  -28.861 -22.383 1.00 42.02 ? 186 ASP   A N   1 
ATOM   1222 C CA  . ASP   A 1 186 ? -8.798  -29.916 -22.186 1.00 40.86 ? 186 ASP   A CA  1 
ATOM   1223 C C   . ASP   A 1 186 ? -8.642  -30.973 -23.273 1.00 43.90 ? 186 ASP   A C   1 
ATOM   1224 O O   . ASP   A 1 186 ? -8.879  -30.691 -24.452 1.00 44.35 ? 186 ASP   A O   1 
ATOM   1225 C CB  . ASP   A 1 186 ? -10.210 -29.330 -22.191 1.00 41.96 ? 186 ASP   A CB  1 
ATOM   1226 C CG  . ASP   A 1 186 ? -11.276 -30.334 -21.753 1.00 41.93 ? 186 ASP   A CG  1 
ATOM   1227 O OD1 . ASP   A 1 186 ? -11.273 -31.484 -22.239 1.00 43.73 ? 186 ASP   A OD1 1 
ATOM   1228 O OD2 . ASP   A 1 186 ? -12.127 -29.967 -20.915 1.00 39.87 ? 186 ASP   A OD2 1 
ATOM   1229 N N   . ILE   A 1 187 ? -8.264  -32.184 -22.872 1.00 45.42 ? 187 ILE   A N   1 
ATOM   1230 C CA  . ILE   A 1 187 ? -8.314  -33.335 -23.763 1.00 44.59 ? 187 ILE   A CA  1 
ATOM   1231 C C   . ILE   A 1 187 ? -9.207  -34.446 -23.230 1.00 45.64 ? 187 ILE   A C   1 
ATOM   1232 O O   . ILE   A 1 187 ? -9.628  -35.312 -24.014 1.00 46.90 ? 187 ILE   A O   1 
ATOM   1233 C CB  . ILE   A 1 187 ? -6.899  -33.880 -24.053 1.00 44.72 ? 187 ILE   A CB  1 
ATOM   1234 C CG1 . ILE   A 1 187 ? -6.871  -34.577 -25.414 1.00 47.01 ? 187 ILE   A CG1 1 
ATOM   1235 C CG2 . ILE   A 1 187 ? -6.464  -34.859 -22.972 1.00 46.91 ? 187 ILE   A CG2 1 
ATOM   1236 C CD1 . ILE   A 1 187 ? -5.512  -35.117 -25.795 1.00 45.45 ? 187 ILE   A CD1 1 
ATOM   1237 N N   . GLY   A 1 188 ? -9.523  -34.453 -21.939 1.00 47.14 ? 188 GLY   A N   1 
ATOM   1238 C CA  . GLY   A 1 188 ? -10.410 -35.439 -21.356 1.00 44.46 ? 188 GLY   A CA  1 
ATOM   1239 C C   . GLY   A 1 188 ? -11.203 -34.860 -20.203 1.00 44.02 ? 188 GLY   A C   1 
ATOM   1240 O O   . GLY   A 1 188 ? -11.434 -35.531 -19.194 1.00 42.10 ? 188 GLY   A O   1 
ATOM   1241 N N   . GLY   A 1 189 ? -11.619 -33.605 -20.344 1.00 40.79 ? 189 GLY   A N   1 
ATOM   1242 C CA  . GLY   A 1 189 ? -12.364 -32.909 -19.314 1.00 42.83 ? 189 GLY   A CA  1 
ATOM   1243 C C   . GLY   A 1 189 ? -11.567 -31.928 -18.493 1.00 36.95 ? 189 GLY   A C   1 
ATOM   1244 O O   . GLY   A 1 189 ? -12.078 -31.437 -17.480 1.00 38.98 ? 189 GLY   A O   1 
ATOM   1245 N N   . ALA   A 1 190 ? -10.337 -31.619 -18.903 1.00 40.14 ? 190 ALA   A N   1 
ATOM   1246 C CA  . ALA   A 1 190 ? -9.409  -30.827 -18.110 1.00 40.79 ? 190 ALA   A CA  1 
ATOM   1247 C C   . ALA   A 1 190 ? -9.903  -29.420 -17.806 1.00 38.30 ? 190 ALA   A C   1 
ATOM   1248 O O   . ALA   A 1 190 ? -9.358  -28.783 -16.898 1.00 40.04 ? 190 ALA   A O   1 
ATOM   1249 C CB  . ALA   A 1 190 ? -8.073  -30.756 -18.832 1.00 44.83 ? 190 ALA   A CB  1 
ATOM   1250 N N   . ILE   A 1 191 ? -10.903 -28.921 -18.523 1.00 38.27 ? 191 ILE   A N   1 
ATOM   1251 C CA  . ILE   A 1 191 ? -11.505 -27.626 -18.225 1.00 39.47 ? 191 ILE   A CA  1 
ATOM   1252 C C   . ILE   A 1 191 ? -12.857 -27.787 -17.548 1.00 40.69 ? 191 ILE   A C   1 
ATOM   1253 O O   . ILE   A 1 191 ? -13.145 -27.128 -16.549 1.00 41.53 ? 191 ILE   A O   1 
ATOM   1254 C CB  . ILE   A 1 191 ? -11.619 -26.777 -19.511 1.00 40.19 ? 191 ILE   A CB  1 
ATOM   1255 C CG1 . ILE   A 1 191 ? -10.235 -26.334 -19.979 1.00 41.30 ? 191 ILE   A CG1 1 
ATOM   1256 C CG2 . ILE   A 1 191 ? -12.513 -25.564 -19.286 1.00 36.61 ? 191 ILE   A CG2 1 
ATOM   1257 C CD1 . ILE   A 1 191 ? -10.236 -25.602 -21.308 1.00 39.68 ? 191 ILE   A CD1 1 
ATOM   1258 N N   . ARG   A 1 192 ? -13.688 -28.690 -18.067 1.00 38.63 ? 192 ARG   A N   1 
ATOM   1259 C CA  . ARG   A 1 192 ? -15.033 -28.864 -17.532 1.00 40.30 ? 192 ARG   A CA  1 
ATOM   1260 C C   . ARG   A 1 192 ? -15.007 -29.488 -16.142 1.00 36.71 ? 192 ARG   A C   1 
ATOM   1261 O O   . ARG   A 1 192 ? -15.809 -29.114 -15.278 1.00 36.27 ? 192 ARG   A O   1 
ATOM   1262 C CB  . ARG   A 1 192 ? -15.868 -29.715 -18.492 1.00 37.13 ? 192 ARG   A CB  1 
ATOM   1263 C CG  . ARG   A 1 192 ? -16.145 -29.042 -19.825 1.00 40.63 ? 192 ARG   A CG  1 
ATOM   1264 C CD  . ARG   A 1 192 ? -16.511 -30.057 -20.893 1.00 39.72 ? 192 ARG   A CD  1 
ATOM   1265 N NE  . ARG   A 1 192 ? -15.337 -30.757 -21.401 1.00 39.95 ? 192 ARG   A NE  1 
ATOM   1266 C CZ  . ARG   A 1 192 ? -15.376 -31.765 -22.260 1.00 41.71 ? 192 ARG   A CZ  1 
ATOM   1267 N NH1 . ARG   A 1 192 ? -16.523 -32.238 -22.718 1.00 41.11 ? 192 ARG   A NH1 1 
ATOM   1268 N NH2 . ARG   A 1 192 ? -14.237 -32.321 -22.660 1.00 40.38 ? 192 ARG   A NH2 1 
ATOM   1269 N N   . VAL   A 1 193 ? -14.098 -30.430 -15.906 1.00 36.46 ? 193 VAL   A N   1 
ATOM   1270 C CA  . VAL   A 1 193 ? -14.050 -31.159 -14.638 1.00 40.34 ? 193 VAL   A CA  1 
ATOM   1271 C C   . VAL   A 1 193 ? -13.559 -30.261 -13.502 1.00 36.44 ? 193 VAL   A C   1 
ATOM   1272 O O   . VAL   A 1 193 ? -14.217 -30.216 -12.453 1.00 35.89 ? 193 VAL   A O   1 
ATOM   1273 C CB  . VAL   A 1 193 ? -13.199 -32.436 -14.758 1.00 39.35 ? 193 VAL   A CB  1 
ATOM   1274 C CG1 . VAL   A 1 193 ? -12.861 -32.992 -13.379 1.00 37.98 ? 193 VAL   A CG1 1 
ATOM   1275 C CG2 . VAL   A 1 193 ? -13.931 -33.479 -15.590 1.00 37.81 ? 193 VAL   A CG2 1 
ATOM   1276 N N   . PRO   A 1 194 ? -12.437 -29.536 -13.631 1.00 40.41 ? 194 PRO   A N   1 
ATOM   1277 C CA  . PRO   A 1 194 ? -12.034 -28.655 -12.516 1.00 37.98 ? 194 PRO   A CA  1 
ATOM   1278 C C   . PRO   A 1 194 ? -13.044 -27.564 -12.214 1.00 37.31 ? 194 PRO   A C   1 
ATOM   1279 O O   . PRO   A 1 194 ? -13.287 -27.252 -11.041 1.00 37.01 ? 194 PRO   A O   1 
ATOM   1280 C CB  . PRO   A 1 194 ? -10.696 -28.076 -12.996 1.00 40.20 ? 194 PRO   A CB  1 
ATOM   1281 C CG  . PRO   A 1 194 ? -10.188 -29.070 -13.946 1.00 40.49 ? 194 PRO   A CG  1 
ATOM   1282 C CD  . PRO   A 1 194 ? -11.396 -29.568 -14.675 1.00 38.74 ? 194 PRO   A CD  1 
ATOM   1283 N N   . ALA   A 1 195 ? -13.637 -26.969 -13.250 1.00 37.67 ? 195 ALA   A N   1 
ATOM   1284 C CA  . ALA   A 1 195 ? -14.730 -26.029 -13.042 1.00 38.52 ? 195 ALA   A CA  1 
ATOM   1285 C C   . ALA   A 1 195 ? -15.909 -26.689 -12.338 1.00 38.45 ? 195 ALA   A C   1 
ATOM   1286 O O   . ALA   A 1 195 ? -16.625 -26.027 -11.577 1.00 39.01 ? 195 ALA   A O   1 
ATOM   1287 C CB  . ALA   A 1 195 ? -15.169 -25.434 -14.382 1.00 37.59 ? 195 ALA   A CB  1 
ATOM   1288 N N   . HIS   A 1 196 ? -16.122 -27.986 -12.568 1.00 36.68 ? 196 HIS   A N   1 
ATOM   1289 C CA  . HIS   A 1 196 ? -17.229 -28.678 -11.916 1.00 36.37 ? 196 HIS   A CA  1 
ATOM   1290 C C   . HIS   A 1 196 ? -16.916 -28.954 -10.449 1.00 40.35 ? 196 HIS   A C   1 
ATOM   1291 O O   . HIS   A 1 196 ? -17.735 -28.675 -9.564  1.00 42.20 ? 196 HIS   A O   1 
ATOM   1292 C CB  . HIS   A 1 196 ? -17.546 -29.974 -12.663 1.00 37.46 ? 196 HIS   A CB  1 
ATOM   1293 C CG  . HIS   A 1 196 ? -18.329 -30.964 -11.855 1.00 37.74 ? 196 HIS   A CG  1 
ATOM   1294 N ND1 . HIS   A 1 196 ? -19.535 -30.658 -11.259 1.00 39.82 ? 196 HIS   A ND1 1 
ATOM   1295 C CD2 . HIS   A 1 196 ? -18.076 -32.258 -11.543 1.00 38.96 ? 196 HIS   A CD2 1 
ATOM   1296 C CE1 . HIS   A 1 196 ? -19.991 -31.721 -10.618 1.00 42.40 ? 196 HIS   A CE1 1 
ATOM   1297 N NE2 . HIS   A 1 196 ? -19.124 -32.704 -10.775 1.00 43.02 ? 196 HIS   A NE2 1 
ATOM   1298 N N   . PHE   A 1 197 ? -15.720 -29.480 -10.171 1.00 37.27 ? 197 PHE   A N   1 
ATOM   1299 C CA  . PHE   A 1 197 ? -15.350 -29.805 -8.796  1.00 36.69 ? 197 PHE   A CA  1 
ATOM   1300 C C   . PHE   A 1 197 ? -15.265 -28.555 -7.930  1.00 37.81 ? 197 PHE   A C   1 
ATOM   1301 O O   . PHE   A 1 197 ? -15.645 -28.581 -6.752  1.00 42.95 ? 197 PHE   A O   1 
ATOM   1302 C CB  . PHE   A 1 197 ? -14.017 -30.554 -8.770  1.00 38.09 ? 197 PHE   A CB  1 
ATOM   1303 C CG  . PHE   A 1 197 ? -14.121 -32.012 -9.132  1.00 37.28 ? 197 PHE   A CG  1 
ATOM   1304 C CD1 . PHE   A 1 197 ? -15.348 -32.595 -9.396  1.00 36.57 ? 197 PHE   A CD1 1 
ATOM   1305 C CD2 . PHE   A 1 197 ? -12.984 -32.801 -9.192  1.00 37.19 ? 197 PHE   A CD2 1 
ATOM   1306 C CE1 . PHE   A 1 197 ? -15.439 -33.938 -9.722  1.00 41.77 ? 197 PHE   A CE1 1 
ATOM   1307 C CE2 . PHE   A 1 197 ? -13.065 -34.143 -9.517  1.00 37.33 ? 197 PHE   A CE2 1 
ATOM   1308 C CZ  . PHE   A 1 197 ? -14.295 -34.714 -9.781  1.00 39.26 ? 197 PHE   A CZ  1 
ATOM   1309 N N   . CYS   A 1 198 ? -14.765 -27.454 -8.491  1.00 37.10 ? 198 CYS   A N   1 
ATOM   1310 C CA  . CYS   A 1 198 ? -14.572 -26.212 -7.754  1.00 39.18 ? 198 CYS   A CA  1 
ATOM   1311 C C   . CYS   A 1 198 ? -15.721 -25.227 -7.927  1.00 39.28 ? 198 CYS   A C   1 
ATOM   1312 O O   . CYS   A 1 198 ? -15.721 -24.178 -7.277  1.00 42.62 ? 198 CYS   A O   1 
ATOM   1313 C CB  . CYS   A 1 198 ? -13.258 -25.548 -8.180  1.00 39.12 ? 198 CYS   A CB  1 
ATOM   1314 S SG  . CYS   A 1 198 ? -11.770 -26.376 -7.583  1.00 38.20 ? 198 CYS   A SG  1 
ATOM   1315 N N   . GLY   A 1 199 ? -16.685 -25.526 -8.791  1.00 38.88 ? 199 GLY   A N   1 
ATOM   1316 C CA  . GLY   A 1 199 ? -17.870 -24.693 -8.923  1.00 38.41 ? 199 GLY   A CA  1 
ATOM   1317 C C   . GLY   A 1 199 ? -17.657 -23.355 -9.597  1.00 39.96 ? 199 GLY   A C   1 
ATOM   1318 O O   . GLY   A 1 199 ? -18.203 -22.342 -9.141  1.00 37.30 ? 199 GLY   A O   1 
ATOM   1319 N N   . VAL   A 1 200 ? -16.873 -23.323 -10.669 1.00 40.12 ? 200 VAL   A N   1 
ATOM   1320 C CA  . VAL   A 1 200 ? -16.662 -22.093 -11.423 1.00 38.63 ? 200 VAL   A CA  1 
ATOM   1321 C C   . VAL   A 1 200 ? -17.064 -22.339 -12.869 1.00 39.03 ? 200 VAL   A C   1 
ATOM   1322 O O   . VAL   A 1 200 ? -17.583 -23.411 -13.206 1.00 40.22 ? 200 VAL   A O   1 
ATOM   1323 C CB  . VAL   A 1 200 ? -15.204 -21.605 -11.322 1.00 39.90 ? 200 VAL   A CB  1 
ATOM   1324 C CG1 . VAL   A 1 200 ? -14.874 -21.215 -9.892  1.00 40.77 ? 200 VAL   A CG1 1 
ATOM   1325 C CG2 . VAL   A 1 200 ? -14.252 -22.674 -11.824 1.00 36.87 ? 200 VAL   A CG2 1 
ATOM   1326 N N   . TRP   A 1 201 ? -16.834 -21.348 -13.728 1.00 42.05 ? 201 TRP   A N   1 
ATOM   1327 C CA  . TRP   A 1 201 ? -17.211 -21.442 -15.129 1.00 38.19 ? 201 TRP   A CA  1 
ATOM   1328 C C   . TRP   A 1 201 ? -16.013 -21.862 -15.966 1.00 37.25 ? 201 TRP   A C   1 
ATOM   1329 O O   . TRP   A 1 201 ? -14.922 -21.302 -15.831 1.00 39.24 ? 201 TRP   A O   1 
ATOM   1330 C CB  . TRP   A 1 201 ? -17.761 -20.108 -15.632 1.00 38.18 ? 201 TRP   A CB  1 
ATOM   1331 C CG  . TRP   A 1 201 ? -19.046 -19.676 -15.006 1.00 42.77 ? 201 TRP   A CG  1 
ATOM   1332 C CD1 . TRP   A 1 201 ? -19.238 -19.273 -13.719 1.00 41.75 ? 201 TRP   A CD1 1 
ATOM   1333 C CD2 . TRP   A 1 201 ? -20.320 -19.576 -15.652 1.00 43.11 ? 201 TRP   A CD2 1 
ATOM   1334 N NE1 . TRP   A 1 201 ? -20.555 -18.937 -13.517 1.00 42.22 ? 201 TRP   A NE1 1 
ATOM   1335 C CE2 . TRP   A 1 201 ? -21.241 -19.116 -14.690 1.00 43.75 ? 201 TRP   A CE2 1 
ATOM   1336 C CE3 . TRP   A 1 201 ? -20.770 -19.833 -16.950 1.00 43.73 ? 201 TRP   A CE3 1 
ATOM   1337 C CZ2 . TRP   A 1 201 ? -22.587 -18.913 -14.983 1.00 43.10 ? 201 TRP   A CZ2 1 
ATOM   1338 C CZ3 . TRP   A 1 201 ? -22.101 -19.629 -17.241 1.00 43.25 ? 201 TRP   A CZ3 1 
ATOM   1339 C CH2 . TRP   A 1 201 ? -22.997 -19.175 -16.263 1.00 40.96 ? 201 TRP   A CH2 1 
ATOM   1340 N N   . GLY   A 1 202 ? -16.227 -22.847 -16.831 1.00 39.29 ? 202 GLY   A N   1 
ATOM   1341 C CA  . GLY   A 1 202 ? -15.198 -23.302 -17.743 1.00 39.70 ? 202 GLY   A CA  1 
ATOM   1342 C C   . GLY   A 1 202 ? -15.791 -23.636 -19.093 1.00 37.01 ? 202 GLY   A C   1 
ATOM   1343 O O   . GLY   A 1 202 ? -16.852 -24.264 -19.177 1.00 36.23 ? 202 GLY   A O   1 
ATOM   1344 N N   . LEU   A 1 203 ? -15.117 -23.215 -20.157 1.00 38.45 ? 203 LEU   A N   1 
ATOM   1345 C CA  . LEU   A 1 203 ? -15.599 -23.413 -21.517 1.00 41.18 ? 203 LEU   A CA  1 
ATOM   1346 C C   . LEU   A 1 203 ? -14.589 -24.248 -22.293 1.00 39.25 ? 203 LEU   A C   1 
ATOM   1347 O O   . LEU   A 1 203 ? -13.503 -23.765 -22.633 1.00 35.81 ? 203 LEU   A O   1 
ATOM   1348 C CB  . LEU   A 1 203 ? -15.843 -22.075 -22.213 1.00 36.73 ? 203 LEU   A CB  1 
ATOM   1349 C CG  . LEU   A 1 203 ? -16.181 -22.222 -23.700 1.00 38.94 ? 203 LEU   A CG  1 
ATOM   1350 C CD1 . LEU   A 1 203 ? -17.481 -22.995 -23.870 1.00 38.76 ? 203 LEU   A CD1 1 
ATOM   1351 C CD2 . LEU   A 1 203 ? -16.259 -20.870 -24.385 1.00 40.14 ? 203 LEU   A CD2 1 
ATOM   1352 N N   . LYS   A 1 204 ? -14.945 -25.501 -22.562 1.00 37.97 ? 204 LYS   A N   1 
ATOM   1353 C CA  . LYS   A 1 204 ? -14.238 -26.288 -23.564 1.00 38.09 ? 204 LYS   A CA  1 
ATOM   1354 C C   . LYS   A 1 204 ? -14.635 -25.773 -24.943 1.00 40.58 ? 204 LYS   A C   1 
ATOM   1355 O O   . LYS   A 1 204 ? -15.821 -25.760 -25.288 1.00 39.90 ? 204 LYS   A O   1 
ATOM   1356 C CB  . LYS   A 1 204 ? -14.573 -27.773 -23.409 1.00 38.92 ? 204 LYS   A CB  1 
ATOM   1357 C CG  . LYS   A 1 204 ? -13.795 -28.712 -24.328 1.00 40.36 ? 204 LYS   A CG  1 
ATOM   1358 C CD  . LYS   A 1 204 ? -14.530 -28.980 -25.634 1.00 37.35 ? 204 LYS   A CD  1 
ATOM   1359 C CE  . LYS   A 1 204 ? -13.689 -29.827 -26.581 1.00 39.44 ? 204 LYS   A CE  1 
ATOM   1360 N NZ  . LYS   A 1 204 ? -14.348 -29.987 -27.905 1.00 37.39 ? 204 LYS   A NZ  1 
ATOM   1361 N N   . THR   A 1 205 ? -13.653 -25.334 -25.722 1.00 38.79 ? 205 THR   A N   1 
ATOM   1362 C CA  . THR   A 1 205 ? -13.927 -24.654 -26.977 1.00 40.15 ? 205 THR   A CA  1 
ATOM   1363 C C   . THR   A 1 205 ? -13.966 -25.635 -28.143 1.00 41.78 ? 205 THR   A C   1 
ATOM   1364 O O   . THR   A 1 205 ? -13.494 -26.772 -28.053 1.00 42.04 ? 205 THR   A O   1 
ATOM   1365 C CB  . THR   A 1 205 ? -12.878 -23.577 -27.248 1.00 39.48 ? 205 THR   A CB  1 
ATOM   1366 O OG1 . THR   A 1 205 ? -11.570 -24.112 -27.014 1.00 39.05 ? 205 THR   A OG1 1 
ATOM   1367 C CG2 . THR   A 1 205 ? -13.102 -22.377 -26.342 1.00 34.70 ? 205 THR   A CG2 1 
ATOM   1368 N N   . THR   A 1 206 ? -14.539 -25.169 -29.250 1.00 40.60 ? 206 THR   A N   1 
ATOM   1369 C CA  . THR   A 1 206 ? -14.573 -25.951 -30.478 1.00 39.08 ? 206 THR   A CA  1 
ATOM   1370 C C   . THR   A 1 206 ? -13.158 -26.334 -30.889 1.00 40.82 ? 206 THR   A C   1 
ATOM   1371 O O   . THR   A 1 206 ? -12.230 -25.527 -30.791 1.00 42.80 ? 206 THR   A O   1 
ATOM   1372 C CB  . THR   A 1 206 ? -15.256 -25.150 -31.591 1.00 39.94 ? 206 THR   A CB  1 
ATOM   1373 O OG1 . THR   A 1 206 ? -16.580 -24.795 -31.177 1.00 42.11 ? 206 THR   A OG1 1 
ATOM   1374 C CG2 . THR   A 1 206 ? -15.339 -25.966 -32.875 1.00 41.25 ? 206 THR   A CG2 1 
ATOM   1375 N N   . PHE   A 1 207 ? -12.993 -27.583 -31.318 1.00 39.19 ? 207 PHE   A N   1 
ATOM   1376 C CA  . PHE   A 1 207 ? -11.677 -28.063 -31.715 1.00 39.53 ? 207 PHE   A CA  1 
ATOM   1377 C C   . PHE   A 1 207 ? -11.131 -27.222 -32.860 1.00 39.87 ? 207 PHE   A C   1 
ATOM   1378 O O   . PHE   A 1 207 ? -11.861 -26.860 -33.787 1.00 43.71 ? 207 PHE   A O   1 
ATOM   1379 C CB  . PHE   A 1 207 ? -11.749 -29.537 -32.121 1.00 40.31 ? 207 PHE   A CB  1 
ATOM   1380 C CG  . PHE   A 1 207 ? -10.425 -30.121 -32.524 1.00 42.86 ? 207 PHE   A CG  1 
ATOM   1381 C CD1 . PHE   A 1 207 ? -9.444  -30.366 -31.577 1.00 38.67 ? 207 PHE   A CD1 1 
ATOM   1382 C CD2 . PHE   A 1 207 ? -10.167 -30.437 -33.846 1.00 42.58 ? 207 PHE   A CD2 1 
ATOM   1383 C CE1 . PHE   A 1 207 ? -8.225  -30.903 -31.946 1.00 41.97 ? 207 PHE   A CE1 1 
ATOM   1384 C CE2 . PHE   A 1 207 ? -8.951  -30.977 -34.221 1.00 43.81 ? 207 PHE   A CE2 1 
ATOM   1385 C CZ  . PHE   A 1 207 ? -7.979  -31.211 -33.269 1.00 46.77 ? 207 PHE   A CZ  1 
ATOM   1386 N N   . ASP   A 1 208 ? -9.842  -26.889 -32.769 1.00 39.64 ? 208 ASP   A N   1 
ATOM   1387 C CA  . ASP   A 1 208 ? -9.099  -26.082 -33.735 1.00 41.43 ? 208 ASP   A CA  1 
ATOM   1388 C C   . ASP   A 1 208 ? -9.497  -24.613 -33.729 1.00 41.63 ? 208 ASP   A C   1 
ATOM   1389 O O   . ASP   A 1 208 ? -9.073  -23.865 -34.619 1.00 38.70 ? 208 ASP   A O   1 
ATOM   1390 C CB  . ASP   A 1 208 ? -9.231  -26.631 -35.162 1.00 42.40 ? 208 ASP   A CB  1 
ATOM   1391 C CG  . ASP   A 1 208 ? -8.038  -27.463 -35.576 1.00 49.23 ? 208 ASP   A CG  1 
ATOM   1392 O OD1 . ASP   A 1 208 ? -6.905  -27.080 -35.223 1.00 48.79 ? 208 ASP   A OD1 1 
ATOM   1393 O OD2 . ASP   A 1 208 ? -8.234  -28.497 -36.248 1.00 54.18 ? 208 ASP   A OD2 1 
ATOM   1394 N N   . ALA   A 1 209 ? -10.286 -24.167 -32.751 1.00 40.51 ? 209 ALA   A N   1 
ATOM   1395 C CA  . ALA   A 1 209 ? -10.722 -22.776 -32.719 1.00 39.58 ? 209 ALA   A CA  1 
ATOM   1396 C C   . ALA   A 1 209 ? -9.717  -21.849 -32.048 1.00 39.17 ? 209 ALA   A C   1 
ATOM   1397 O O   . ALA   A 1 209 ? -9.680  -20.656 -32.370 1.00 38.83 ? 209 ALA   A O   1 
ATOM   1398 C CB  . ALA   A 1 209 ? -12.073 -22.654 -32.011 1.00 37.58 ? 209 ALA   A CB  1 
ATOM   1399 N N   . VAL   A 1 210 ? -8.908  -22.357 -31.121 1.00 39.90 ? 210 VAL   A N   1 
ATOM   1400 C CA  . VAL   A 1 210 ? -7.899  -21.556 -30.439 1.00 39.43 ? 210 VAL   A CA  1 
ATOM   1401 C C   . VAL   A 1 210 ? -6.547  -22.235 -30.607 1.00 39.95 ? 210 VAL   A C   1 
ATOM   1402 O O   . VAL   A 1 210 ? -6.431  -23.456 -30.459 1.00 40.07 ? 210 VAL   A O   1 
ATOM   1403 C CB  . VAL   A 1 210 ? -8.231  -21.360 -28.944 1.00 38.64 ? 210 VAL   A CB  1 
ATOM   1404 C CG1 . VAL   A 1 210 ? -7.281  -20.350 -28.319 1.00 36.89 ? 210 VAL   A CG1 1 
ATOM   1405 C CG2 . VAL   A 1 210 ? -9.677  -20.917 -28.768 1.00 36.14 ? 210 VAL   A CG2 1 
ATOM   1406 N N   . SER   A 1 211 ? -5.528  -21.443 -30.921 1.00 40.03 ? 211 SER   A N   1 
ATOM   1407 C CA  . SER   A 1 211 ? -4.202  -21.993 -31.164 1.00 39.12 ? 211 SER   A CA  1 
ATOM   1408 C C   . SER   A 1 211 ? -3.603  -22.554 -29.880 1.00 42.32 ? 211 SER   A C   1 
ATOM   1409 O O   . SER   A 1 211 ? -3.733  -21.967 -28.803 1.00 39.44 ? 211 SER   A O   1 
ATOM   1410 C CB  . SER   A 1 211 ? -3.281  -20.922 -31.745 1.00 37.06 ? 211 SER   A CB  1 
ATOM   1411 O OG  . SER   A 1 211 ? -1.954  -21.406 -31.847 1.00 44.53 ? 211 SER   A OG  1 
ATOM   1412 N N   . LEU   A 1 212 ? -2.945  -23.704 -30.003 1.00 44.19 ? 212 LEU   A N   1 
ATOM   1413 C CA  . LEU   A 1 212 ? -2.252  -24.329 -28.885 1.00 40.15 ? 212 LEU   A CA  1 
ATOM   1414 C C   . LEU   A 1 212 ? -0.775  -23.960 -28.838 1.00 42.34 ? 212 LEU   A C   1 
ATOM   1415 O O   . LEU   A 1 212 ? -0.014  -24.588 -28.095 1.00 41.86 ? 212 LEU   A O   1 
ATOM   1416 C CB  . LEU   A 1 212 ? -2.399  -25.855 -28.941 1.00 40.69 ? 212 LEU   A CB  1 
ATOM   1417 C CG  . LEU   A 1 212 ? -3.780  -26.522 -29.013 1.00 43.91 ? 212 LEU   A CG  1 
ATOM   1418 C CD1 . LEU   A 1 212 ? -3.722  -27.925 -28.420 1.00 47.07 ? 212 LEU   A CD1 1 
ATOM   1419 C CD2 . LEU   A 1 212 ? -4.861  -25.696 -28.336 1.00 46.95 ? 212 LEU   A CD2 1 
ATOM   1420 N N   . GLU   A 1 213 ? -0.354  -22.958 -29.609 1.00 42.88 ? 213 GLU   A N   1 
ATOM   1421 C CA  . GLU   A 1 213 ? 1.054   -22.584 -29.647 1.00 44.94 ? 213 GLU   A CA  1 
ATOM   1422 C C   . GLU   A 1 213 ? 1.519   -22.117 -28.275 1.00 45.07 ? 213 GLU   A C   1 
ATOM   1423 O O   . GLU   A 1 213 ? 0.846   -21.323 -27.611 1.00 43.54 ? 213 GLU   A O   1 
ATOM   1424 C CB  . GLU   A 1 213 ? 1.284   -21.489 -30.688 1.00 42.43 ? 213 GLU   A CB  1 
ATOM   1425 C CG  . GLU   A 1 213 ? 2.714   -20.980 -30.739 1.00 45.29 ? 213 GLU   A CG  1 
ATOM   1426 C CD  . GLU   A 1 213 ? 2.904   -19.889 -31.766 1.00 51.02 ? 213 GLU   A CD  1 
ATOM   1427 O OE1 . GLU   A 1 213 ? 2.405   -20.042 -32.899 1.00 53.25 ? 213 GLU   A OE1 1 
ATOM   1428 O OE2 . GLU   A 1 213 ? 3.551   -18.875 -31.442 1.00 51.23 ? 213 GLU   A OE2 1 
ATOM   1429 N N   . GLY   A 1 214 ? 2.681   -22.612 -27.854 1.00 42.28 ? 214 GLY   A N   1 
ATOM   1430 C CA  . GLY   A 1 214 ? 3.200   -22.335 -26.538 1.00 44.57 ? 214 GLY   A CA  1 
ATOM   1431 C C   . GLY   A 1 214 ? 2.731   -23.287 -25.460 1.00 45.42 ? 214 GLY   A C   1 
ATOM   1432 O O   . GLY   A 1 214 ? 3.330   -23.312 -24.377 1.00 46.18 ? 214 GLY   A O   1 
ATOM   1433 N N   . HIS   A 1 215 ? 1.679   -24.067 -25.715 1.00 43.91 ? 215 HIS   A N   1 
ATOM   1434 C CA  . HIS   A 1 215 ? 1.290   -25.151 -24.821 1.00 42.53 ? 215 HIS   A CA  1 
ATOM   1435 C C   . HIS   A 1 215 ? 2.171   -26.359 -25.115 1.00 42.16 ? 215 HIS   A C   1 
ATOM   1436 O O   . HIS   A 1 215 ? 1.679   -27.478 -25.297 1.00 40.48 ? 215 HIS   A O   1 
ATOM   1437 C CB  . HIS   A 1 215 ? -0.194  -25.494 -24.993 1.00 40.83 ? 215 HIS   A CB  1 
ATOM   1438 C CG  . HIS   A 1 215 ? -0.753  -26.344 -23.895 1.00 42.31 ? 215 HIS   A CG  1 
ATOM   1439 N ND1 . HIS   A 1 215 ? -0.732  -27.722 -23.934 1.00 43.20 ? 215 HIS   A ND1 1 
ATOM   1440 C CD2 . HIS   A 1 215 ? -1.361  -26.012 -22.731 1.00 45.51 ? 215 HIS   A CD2 1 
ATOM   1441 C CE1 . HIS   A 1 215 ? -1.294  -28.201 -22.839 1.00 41.16 ? 215 HIS   A CE1 1 
ATOM   1442 N NE2 . HIS   A 1 215 ? -1.687  -27.184 -22.094 1.00 42.19 ? 215 HIS   A NE2 1 
ATOM   1443 N N   . TYR   A 1 216 ? 3.479   -26.129 -25.171 1.00 43.29 ? 216 TYR   A N   1 
ATOM   1444 C CA  . TYR   A 1 216 ? 4.425   -27.150 -25.588 1.00 43.56 ? 216 TYR   A CA  1 
ATOM   1445 C C   . TYR   A 1 216 ? 4.691   -28.133 -24.459 1.00 43.14 ? 216 TYR   A C   1 
ATOM   1446 O O   . TYR   A 1 216 ? 4.709   -27.759 -23.281 1.00 45.04 ? 216 TYR   A O   1 
ATOM   1447 C CB  . TYR   A 1 216 ? 5.743   -26.507 -26.026 1.00 44.73 ? 216 TYR   A CB  1 
ATOM   1448 C CG  . TYR   A 1 216 ? 5.637   -25.591 -27.227 1.00 47.20 ? 216 TYR   A CG  1 
ATOM   1449 C CD1 . TYR   A 1 216 ? 4.958   -25.989 -28.369 1.00 43.49 ? 216 TYR   A CD1 1 
ATOM   1450 C CD2 . TYR   A 1 216 ? 6.217   -24.328 -27.219 1.00 46.04 ? 216 TYR   A CD2 1 
ATOM   1451 C CE1 . TYR   A 1 216 ? 4.856   -25.160 -29.470 1.00 45.83 ? 216 TYR   A CE1 1 
ATOM   1452 C CE2 . TYR   A 1 216 ? 6.122   -23.490 -28.319 1.00 42.84 ? 216 TYR   A CE2 1 
ATOM   1453 C CZ  . TYR   A 1 216 ? 5.440   -23.912 -29.441 1.00 45.96 ? 216 TYR   A CZ  1 
ATOM   1454 O OH  . TYR   A 1 216 ? 5.338   -23.084 -30.535 1.00 46.00 ? 216 TYR   A OH  1 
ATOM   1455 N N   . PHE   A 1 217 ? 4.881   -29.396 -24.822 1.00 43.30 ? 217 PHE   A N   1 
ATOM   1456 C CA  . PHE   A 1 217 ? 5.493   -30.328 -23.892 1.00 44.02 ? 217 PHE   A CA  1 
ATOM   1457 C C   . PHE   A 1 217 ? 6.895   -29.828 -23.550 1.00 46.01 ? 217 PHE   A C   1 
ATOM   1458 O O   . PHE   A 1 217 ? 7.605   -29.331 -24.434 1.00 41.20 ? 217 PHE   A O   1 
ATOM   1459 C CB  . PHE   A 1 217 ? 5.561   -31.733 -24.495 1.00 44.59 ? 217 PHE   A CB  1 
ATOM   1460 C CG  . PHE   A 1 217 ? 6.083   -32.776 -23.547 1.00 48.53 ? 217 PHE   A CG  1 
ATOM   1461 C CD1 . PHE   A 1 217 ? 5.226   -33.431 -22.679 1.00 48.97 ? 217 PHE   A CD1 1 
ATOM   1462 C CD2 . PHE   A 1 217 ? 7.430   -33.101 -23.521 1.00 47.78 ? 217 PHE   A CD2 1 
ATOM   1463 C CE1 . PHE   A 1 217 ? 5.702   -34.387 -21.801 1.00 49.07 ? 217 PHE   A CE1 1 
ATOM   1464 C CE2 . PHE   A 1 217 ? 7.912   -34.056 -22.646 1.00 45.87 ? 217 PHE   A CE2 1 
ATOM   1465 C CZ  . PHE   A 1 217 ? 7.047   -34.699 -21.785 1.00 45.16 ? 217 PHE   A CZ  1 
ATOM   1466 N N   . PRO   A 1 218 ? 7.314   -29.919 -22.287 1.00 44.43 ? 218 PRO   A N   1 
ATOM   1467 C CA  . PRO   A 1 218 ? 8.593   -29.317 -21.883 1.00 45.46 ? 218 PRO   A CA  1 
ATOM   1468 C C   . PRO   A 1 218 ? 9.757   -29.807 -22.735 1.00 45.18 ? 218 PRO   A C   1 
ATOM   1469 O O   . PRO   A 1 218 ? 9.868   -30.995 -23.044 1.00 43.33 ? 218 PRO   A O   1 
ATOM   1470 C CB  . PRO   A 1 218 ? 8.739   -29.752 -20.421 1.00 45.49 ? 218 PRO   A CB  1 
ATOM   1471 C CG  . PRO   A 1 218 ? 7.334   -29.935 -19.949 1.00 45.56 ? 218 PRO   A CG  1 
ATOM   1472 C CD  . PRO   A 1 218 ? 6.569   -30.459 -21.136 1.00 44.50 ? 218 PRO   A CD  1 
ATOM   1473 N N   . ARG   A 1 219 ? 10.617  -28.863 -23.123 1.00 44.46 ? 219 ARG   A N   1 
ATOM   1474 C CA  . ARG   A 1 219 ? 11.855  -29.061 -23.882 1.00 44.55 ? 219 ARG   A CA  1 
ATOM   1475 C C   . ARG   A 1 219 ? 11.602  -29.453 -25.334 1.00 48.57 ? 219 ARG   A C   1 
ATOM   1476 O O   . ARG   A 1 219 ? 12.548  -29.862 -26.026 1.00 45.72 ? 219 ARG   A O   1 
ATOM   1477 C CB  . ARG   A 1 219 ? 12.775  -30.093 -23.217 1.00 43.68 ? 219 ARG   A CB  1 
ATOM   1478 C CG  . ARG   A 1 219 ? 12.893  -29.919 -21.703 1.00 45.61 ? 219 ARG   A CG  1 
ATOM   1479 C CD  . ARG   A 1 219 ? 14.178  -30.508 -21.156 1.00 47.72 ? 219 ARG   A CD  1 
ATOM   1480 N NE  . ARG   A 1 219 ? 14.925  -29.525 -20.379 1.00 48.32 ? 219 ARG   A NE  1 
ATOM   1481 C CZ  . ARG   A 1 219 ? 14.858  -29.402 -19.060 1.00 48.01 ? 219 ARG   A CZ  1 
ATOM   1482 N NH1 . ARG   A 1 219 ? 14.095  -30.199 -18.329 1.00 48.75 ? 219 ARG   A NH1 1 
ATOM   1483 N NH2 . ARG   A 1 219 ? 15.576  -28.458 -18.460 1.00 50.79 ? 219 ARG   A NH2 1 
ATOM   1484 N N   . THR   A 1 220 ? 10.367  -29.344 -25.821 1.00 50.20 ? 220 THR   A N   1 
ATOM   1485 C CA  . THR   A 1 220 ? 10.036  -29.568 -27.221 1.00 45.00 ? 220 THR   A CA  1 
ATOM   1486 C C   . THR   A 1 220 ? 9.206   -28.393 -27.723 1.00 45.79 ? 220 THR   A C   1 
ATOM   1487 O O   . THR   A 1 220 ? 8.839   -27.493 -26.963 1.00 44.95 ? 220 THR   A O   1 
ATOM   1488 C CB  . THR   A 1 220 ? 9.262   -30.883 -27.425 1.00 46.24 ? 220 THR   A CB  1 
ATOM   1489 O OG1 . THR   A 1 220 ? 7.924   -30.736 -26.930 1.00 46.27 ? 220 THR   A OG1 1 
ATOM   1490 C CG2 . THR   A 1 220 ? 9.937   -32.039 -26.691 1.00 44.25 ? 220 THR   A CG2 1 
ATOM   1491 N N   . ASP   A 1 221 ? 8.908   -28.402 -29.021 1.00 46.50 ? 221 ASP   A N   1 
ATOM   1492 C CA  . ASP   A 1 221 ? 7.927   -27.495 -29.610 1.00 46.71 ? 221 ASP   A CA  1 
ATOM   1493 C C   . ASP   A 1 221 ? 6.732   -28.276 -30.147 1.00 45.48 ? 221 ASP   A C   1 
ATOM   1494 O O   . ASP   A 1 221 ? 6.151   -27.936 -31.178 1.00 47.04 ? 221 ASP   A O   1 
ATOM   1495 C CB  . ASP   A 1 221 ? 8.552   -26.628 -30.701 1.00 44.76 ? 221 ASP   A CB  1 
ATOM   1496 C CG  . ASP   A 1 221 ? 9.113   -27.437 -31.854 1.00 46.56 ? 221 ASP   A CG  1 
ATOM   1497 O OD1 . ASP   A 1 221 ? 9.115   -28.682 -31.775 1.00 48.93 ? 221 ASP   A OD1 1 
ATOM   1498 O OD2 . ASP   A 1 221 ? 9.554   -26.817 -32.845 1.00 46.56 ? 221 ASP   A OD2 1 
ATOM   1499 N N   . SER   A 1 222 ? 6.363   -29.344 -29.446 1.00 48.12 ? 222 SER   A N   1 
ATOM   1500 C CA  . SER   A 1 222 ? 5.211   -30.165 -29.796 1.00 47.00 ? 222 SER   A CA  1 
ATOM   1501 C C   . SER   A 1 222 ? 4.027   -29.708 -28.951 1.00 44.82 ? 222 SER   A C   1 
ATOM   1502 O O   . SER   A 1 222 ? 4.012   -29.914 -27.733 1.00 47.42 ? 222 SER   A O   1 
ATOM   1503 C CB  . SER   A 1 222 ? 5.509   -31.646 -29.569 1.00 44.00 ? 222 SER   A CB  1 
ATOM   1504 O OG  . SER   A 1 222 ? 6.689   -32.043 -30.246 1.00 48.86 ? 222 SER   A OG  1 
ATOM   1505 N N   . ALA   A 1 223 ? 3.040   -29.089 -29.595 1.00 43.58 ? 223 ALA   A N   1 
ATOM   1506 C CA  . ALA   A 1 223 ? 1.850   -28.601 -28.908 1.00 46.97 ? 223 ALA   A CA  1 
ATOM   1507 C C   . ALA   A 1 223 ? 0.565   -29.150 -29.501 1.00 51.05 ? 223 ALA   A C   1 
ATOM   1508 O O   . ALA   A 1 223 ? -0.322  -29.582 -28.753 1.00 51.14 ? 223 ALA   A O   1 
ATOM   1509 C CB  . ALA   A 1 223 ? 1.813   -27.066 -28.932 1.00 44.95 ? 223 ALA   A CB  1 
ATOM   1510 N N   . LYS   A 1 224 ? 0.436   -29.141 -30.826 1.00 53.33 ? 224 LYS   A N   1 
ATOM   1511 C CA  . LYS   A 1 224 ? -0.792  -29.599 -31.461 1.00 54.82 ? 224 LYS   A CA  1 
ATOM   1512 C C   . LYS   A 1 224 ? -1.040  -31.072 -31.167 1.00 53.88 ? 224 LYS   A C   1 
ATOM   1513 O O   . LYS   A 1 224 ? -0.119  -31.895 -31.188 1.00 55.23 ? 224 LYS   A O   1 
ATOM   1514 C CB  . LYS   A 1 224 ? -0.728  -29.368 -32.971 1.00 53.73 ? 224 LYS   A CB  1 
ATOM   1515 C CG  . LYS   A 1 224 ? -1.557  -28.191 -33.450 1.00 54.88 ? 224 LYS   A CG  1 
ATOM   1516 C CD  . LYS   A 1 224 ? -1.471  -28.042 -34.956 1.00 62.36 ? 224 LYS   A CD  1 
ATOM   1517 C CE  . LYS   A 1 224 ? -2.396  -26.944 -35.455 1.00 61.25 ? 224 LYS   A CE  1 
ATOM   1518 N NZ  . LYS   A 1 224 ? -3.828  -27.314 -35.298 1.00 57.81 ? 224 LYS   A NZ  1 
ATOM   1519 N N   . ALA   A 1 225 ? -2.300  -31.398 -30.887 1.00 53.30 ? 225 ALA   A N   1 
ATOM   1520 C CA  . ALA   A 1 225 ? -2.708  -32.772 -30.635 1.00 55.34 ? 225 ALA   A CA  1 
ATOM   1521 C C   . ALA   A 1 225 ? -4.210  -32.859 -30.844 1.00 54.15 ? 225 ALA   A C   1 
ATOM   1522 O O   . ALA   A 1 225 ? -4.951  -31.988 -30.379 1.00 51.80 ? 225 ALA   A O   1 
ATOM   1523 C CB  . ALA   A 1 225 ? -2.330  -33.215 -29.218 1.00 52.63 ? 225 ALA   A CB  1 
ATOM   1524 N N   . ASP   A 1 226 ? -4.652  -33.898 -31.548 1.00 51.74 ? 226 ASP   A N   1 
ATOM   1525 C CA  . ASP   A 1 226 ? -6.073  -34.075 -31.806 1.00 48.03 ? 226 ASP   A CA  1 
ATOM   1526 C C   . ASP   A 1 226 ? -6.848  -34.166 -30.493 1.00 47.37 ? 226 ASP   A C   1 
ATOM   1527 O O   . ASP   A 1 226 ? -6.295  -34.479 -29.434 1.00 45.35 ? 226 ASP   A O   1 
ATOM   1528 C CB  . ASP   A 1 226 ? -6.309  -35.324 -32.654 1.00 50.57 ? 226 ASP   A CB  1 
ATOM   1529 C CG  . ASP   A 1 226 ? -5.837  -35.153 -34.083 1.00 52.35 ? 226 ASP   A CG  1 
ATOM   1530 O OD1 . ASP   A 1 226 ? -6.386  -34.287 -34.796 1.00 51.00 ? 226 ASP   A OD1 1 
ATOM   1531 O OD2 . ASP   A 1 226 ? -4.909  -35.879 -34.491 1.00 50.45 ? 226 ASP   A OD2 1 
ATOM   1532 N N   . LEU   A 1 227 ? -8.144  -33.846 -30.574 1.00 45.37 ? 227 LEU   A N   1 
ATOM   1533 C CA  . LEU   A 1 227 ? -9.070  -33.852 -29.441 1.00 44.82 ? 227 LEU   A CA  1 
ATOM   1534 C C   . LEU   A 1 227 ? -8.799  -32.712 -28.462 1.00 42.01 ? 227 LEU   A C   1 
ATOM   1535 O O   . LEU   A 1 227 ? -9.738  -32.147 -27.890 1.00 40.27 ? 227 LEU   A O   1 
ATOM   1536 C CB  . LEU   A 1 227 ? -9.024  -35.195 -28.703 1.00 42.74 ? 227 LEU   A CB  1 
ATOM   1537 C CG  . LEU   A 1 227 ? -9.287  -36.460 -29.520 1.00 43.38 ? 227 LEU   A CG  1 
ATOM   1538 C CD1 . LEU   A 1 227 ? -8.786  -37.683 -28.769 1.00 42.03 ? 227 LEU   A CD1 1 
ATOM   1539 C CD2 . LEU   A 1 227 ? -10.768 -36.593 -29.832 1.00 39.72 ? 227 LEU   A CD2 1 
ATOM   1540 N N   . SER   A 1 228 ? -7.531  -32.362 -28.262 1.00 43.05 ? 228 SER   A N   1 
ATOM   1541 C CA  . SER   A 1 228 ? -7.173  -31.371 -27.256 1.00 43.65 ? 228 SER   A CA  1 
ATOM   1542 C C   . SER   A 1 228 ? -7.543  -29.961 -27.702 1.00 43.63 ? 228 SER   A C   1 
ATOM   1543 O O   . SER   A 1 228 ? -7.386  -29.598 -28.871 1.00 41.97 ? 228 SER   A O   1 
ATOM   1544 C CB  . SER   A 1 228 ? -5.677  -31.445 -26.955 1.00 41.78 ? 228 SER   A CB  1 
ATOM   1545 O OG  . SER   A 1 228 ? -5.273  -30.364 -26.135 1.00 53.47 ? 228 SER   A OG  1 
ATOM   1546 N N   . VAL   A 1 229 ? -8.043  -29.163 -26.753 1.00 41.53 ? 229 VAL   A N   1 
ATOM   1547 C CA  . VAL   A 1 229 ? -8.366  -27.756 -26.965 1.00 42.32 ? 229 VAL   A CA  1 
ATOM   1548 C C   . VAL   A 1 229 ? -7.905  -26.965 -25.747 1.00 41.53 ? 229 VAL   A C   1 
ATOM   1549 O O   . VAL   A 1 229 ? -7.566  -27.525 -24.703 1.00 41.04 ? 229 VAL   A O   1 
ATOM   1550 C CB  . VAL   A 1 229 ? -9.874  -27.514 -27.199 1.00 40.21 ? 229 VAL   A CB  1 
ATOM   1551 C CG1 . VAL   A 1 229 ? -10.433 -28.460 -28.252 1.00 39.27 ? 229 VAL   A CG1 1 
ATOM   1552 C CG2 . VAL   A 1 229 ? -10.639 -27.634 -25.888 1.00 40.30 ? 229 VAL   A CG2 1 
ATOM   1553 N N   . VAL   A 1 230 ? -7.904  -25.642 -25.894 1.00 42.51 ? 230 VAL   A N   1 
ATOM   1554 C CA  . VAL   A 1 230 ? -7.679  -24.727 -24.784 1.00 38.66 ? 230 VAL   A CA  1 
ATOM   1555 C C   . VAL   A 1 230 ? -8.844  -23.748 -24.737 1.00 38.64 ? 230 VAL   A C   1 
ATOM   1556 O O   . VAL   A 1 230 ? -9.425  -23.397 -25.769 1.00 37.83 ? 230 VAL   A O   1 
ATOM   1557 C CB  . VAL   A 1 230 ? -6.333  -23.977 -24.894 1.00 41.51 ? 230 VAL   A CB  1 
ATOM   1558 C CG1 . VAL   A 1 230 ? -5.172  -24.954 -24.820 1.00 38.13 ? 230 VAL   A CG1 1 
ATOM   1559 C CG2 . VAL   A 1 230 ? -6.274  -23.159 -26.174 1.00 37.47 ? 230 VAL   A CG2 1 
ATOM   1560 N N   . GLY   A 1 231 ? -9.191  -23.318 -23.527 1.00 36.05 ? 231 GLY   A N   1 
ATOM   1561 C CA  . GLY   A 1 231 ? -10.341 -22.471 -23.322 1.00 36.59 ? 231 GLY   A CA  1 
ATOM   1562 C C   . GLY   A 1 231 ? -10.285 -21.688 -22.026 1.00 38.52 ? 231 GLY   A C   1 
ATOM   1563 O O   . GLY   A 1 231 ? -9.523  -22.006 -21.109 1.00 39.27 ? 231 GLY   A O   1 
ATOM   1564 N N   . PRO   A 1 232 ? -11.102 -20.644 -21.926 1.00 39.51 ? 232 PRO   A N   1 
ATOM   1565 C CA  . PRO   A 1 232 ? -11.055 -19.777 -20.747 1.00 38.06 ? 232 PRO   A CA  1 
ATOM   1566 C C   . PRO   A 1 232 ? -11.830 -20.345 -19.569 1.00 39.83 ? 232 PRO   A C   1 
ATOM   1567 O O   . PRO   A 1 232 ? -12.772 -21.129 -19.721 1.00 39.53 ? 232 PRO   A O   1 
ATOM   1568 C CB  . PRO   A 1 232 ? -11.695 -18.479 -21.250 1.00 37.51 ? 232 PRO   A CB  1 
ATOM   1569 C CG  . PRO   A 1 232 ? -12.687 -18.950 -22.267 1.00 38.74 ? 232 PRO   A CG  1 
ATOM   1570 C CD  . PRO   A 1 232 ? -12.067 -20.160 -22.932 1.00 39.03 ? 232 PRO   A CD  1 
ATOM   1571 N N   . MET   A 1 233 ? -11.406 -19.927 -18.375 1.00 38.12 ? 233 MET   A N   1 
ATOM   1572 C CA  . MET   A 1 233 ? -12.071 -20.267 -17.124 1.00 42.02 ? 233 MET   A CA  1 
ATOM   1573 C C   . MET   A 1 233 ? -12.202 -19.001 -16.291 1.00 42.92 ? 233 MET   A C   1 
ATOM   1574 O O   . MET   A 1 233 ? -11.236 -18.242 -16.159 1.00 42.42 ? 233 MET   A O   1 
ATOM   1575 C CB  . MET   A 1 233 ? -11.289 -21.342 -16.353 1.00 42.05 ? 233 MET   A CB  1 
ATOM   1576 C CG  . MET   A 1 233 ? -11.003 -22.613 -17.147 1.00 40.61 ? 233 MET   A CG  1 
ATOM   1577 S SD  . MET   A 1 233 ? -9.875  -23.740 -16.301 1.00 49.51 ? 233 MET   A SD  1 
ATOM   1578 C CE  . MET   A 1 233 ? -10.851 -24.200 -14.870 1.00 35.81 ? 233 MET   A CE  1 
ATOM   1579 N N   . ALA   A 1 234 ? -13.388 -18.770 -15.737 1.00 40.07 ? 234 ALA   A N   1 
ATOM   1580 C CA  . ALA   A 1 234 ? -13.661 -17.548 -14.988 1.00 42.33 ? 234 ALA   A CA  1 
ATOM   1581 C C   . ALA   A 1 234 ? -14.820 -17.809 -14.031 1.00 43.94 ? 234 ALA   A C   1 
ATOM   1582 O O   . ALA   A 1 234 ? -15.229 -18.956 -13.820 1.00 42.12 ? 234 ALA   A O   1 
ATOM   1583 C CB  . ALA   A 1 234 ? -13.951 -16.382 -15.941 1.00 42.32 ? 234 ALA   A CB  1 
ATOM   1584 N N   . ARG   A 1 235 ? -15.351 -16.735 -13.446 1.00 42.05 ? 235 ARG   A N   1 
ATOM   1585 C CA  . ARG   A 1 235 ? -16.485 -16.822 -12.538 1.00 41.22 ? 235 ARG   A CA  1 
ATOM   1586 C C   . ARG   A 1 235 ? -17.784 -16.296 -13.129 1.00 40.95 ? 235 ARG   A C   1 
ATOM   1587 O O   . ARG   A 1 235 ? -18.844 -16.518 -12.534 1.00 38.96 ? 235 ARG   A O   1 
ATOM   1588 C CB  . ARG   A 1 235 ? -16.188 -16.066 -11.234 1.00 38.98 ? 235 ARG   A CB  1 
ATOM   1589 C CG  . ARG   A 1 235 ? -15.264 -16.807 -10.287 1.00 41.25 ? 235 ARG   A CG  1 
ATOM   1590 C CD  . ARG   A 1 235 ? -15.174 -16.100 -8.947  1.00 36.31 ? 235 ARG   A CD  1 
ATOM   1591 N NE  . ARG   A 1 235 ? -14.554 -14.787 -9.063  1.00 39.72 ? 235 ARG   A NE  1 
ATOM   1592 C CZ  . ARG   A 1 235 ? -13.257 -14.560 -8.913  1.00 41.64 ? 235 ARG   A CZ  1 
ATOM   1593 N NH1 . ARG   A 1 235 ? -12.409 -15.543 -8.656  1.00 39.32 ? 235 ARG   A NH1 1 
ATOM   1594 N NH2 . ARG   A 1 235 ? -12.799 -13.317 -9.018  1.00 41.74 ? 235 ARG   A NH2 1 
ATOM   1595 N N   . THR   A 1 236 ? -17.737 -15.599 -14.261 1.00 42.31 ? 236 THR   A N   1 
ATOM   1596 C CA  . THR   A 1 236 ? -18.924 -15.108 -14.941 1.00 42.73 ? 236 THR   A CA  1 
ATOM   1597 C C   . THR   A 1 236 ? -18.871 -15.509 -16.406 1.00 42.79 ? 236 THR   A C   1 
ATOM   1598 O O   . THR   A 1 236 ? -17.785 -15.612 -16.985 1.00 41.20 ? 236 THR   A O   1 
ATOM   1599 C CB  . THR   A 1 236 ? -19.053 -13.580 -14.842 1.00 43.55 ? 236 THR   A CB  1 
ATOM   1600 O OG1 . THR   A 1 236 ? -18.163 -12.963 -15.778 1.00 45.07 ? 236 THR   A OG1 1 
ATOM   1601 C CG2 . THR   A 1 236 ? -18.717 -13.096 -13.437 1.00 36.26 ? 236 THR   A CG2 1 
ATOM   1602 N N   . PRO   A 1 237 ? -20.028 -15.742 -17.033 1.00 44.78 ? 237 PRO   A N   1 
ATOM   1603 C CA  . PRO   A 1 237 ? -20.016 -16.093 -18.461 1.00 41.43 ? 237 PRO   A CA  1 
ATOM   1604 C C   . PRO   A 1 237 ? -19.558 -14.958 -19.358 1.00 42.42 ? 237 PRO   A C   1 
ATOM   1605 O O   . PRO   A 1 237 ? -18.983 -15.222 -20.421 1.00 40.99 ? 237 PRO   A O   1 
ATOM   1606 C CB  . PRO   A 1 237 ? -21.475 -16.479 -18.739 1.00 40.95 ? 237 PRO   A CB  1 
ATOM   1607 C CG  . PRO   A 1 237 ? -22.258 -15.752 -17.696 1.00 43.81 ? 237 PRO   A CG  1 
ATOM   1608 C CD  . PRO   A 1 237 ? -21.390 -15.765 -16.472 1.00 42.89 ? 237 PRO   A CD  1 
ATOM   1609 N N   . ALA   A 1 238 ? -19.800 -13.702 -18.971 1.00 41.69 ? 238 ALA   A N   1 
ATOM   1610 C CA  . ALA   A 1 238 ? -19.366 -12.580 -19.797 1.00 42.16 ? 238 ALA   A CA  1 
ATOM   1611 C C   . ALA   A 1 238 ? -17.847 -12.523 -19.893 1.00 43.52 ? 238 ALA   A C   1 
ATOM   1612 O O   . ALA   A 1 238 ? -17.298 -12.156 -20.937 1.00 43.18 ? 238 ALA   A O   1 
ATOM   1613 C CB  . ALA   A 1 238 ? -19.920 -11.268 -19.242 1.00 41.04 ? 238 ALA   A CB  1 
ATOM   1614 N N   . ASP   A 1 239 ? -17.149 -12.883 -18.813 1.00 40.25 ? 239 ASP   A N   1 
ATOM   1615 C CA  . ASP   A 1 239 ? -15.692 -12.952 -18.868 1.00 42.31 ? 239 ASP   A CA  1 
ATOM   1616 C C   . ASP   A 1 239 ? -15.232 -14.018 -19.852 1.00 41.89 ? 239 ASP   A C   1 
ATOM   1617 O O   . ASP   A 1 239 ? -14.230 -13.833 -20.555 1.00 42.09 ? 239 ASP   A O   1 
ATOM   1618 C CB  . ASP   A 1 239 ? -15.125 -13.226 -17.475 1.00 42.23 ? 239 ASP   A CB  1 
ATOM   1619 C CG  . ASP   A 1 239 ? -15.328 -12.063 -16.531 1.00 47.54 ? 239 ASP   A CG  1 
ATOM   1620 O OD1 . ASP   A 1 239 ? -15.841 -11.023 -16.988 1.00 50.32 ? 239 ASP   A OD1 1 
ATOM   1621 O OD2 . ASP   A 1 239 ? -14.977 -12.187 -15.339 1.00 47.99 ? 239 ASP   A OD2 1 
ATOM   1622 N N   . LEU   A 1 240 ? -15.953 -15.140 -19.916 1.00 38.88 ? 240 LEU   A N   1 
ATOM   1623 C CA  . LEU   A 1 240 ? -15.623 -16.184 -20.880 1.00 40.96 ? 240 LEU   A CA  1 
ATOM   1624 C C   . LEU   A 1 240 ? -15.767 -15.674 -22.308 1.00 42.08 ? 240 LEU   A C   1 
ATOM   1625 O O   . LEU   A 1 240 ? -14.913 -15.932 -23.164 1.00 41.12 ? 240 LEU   A O   1 
ATOM   1626 C CB  . LEU   A 1 240 ? -16.518 -17.401 -20.655 1.00 38.50 ? 240 LEU   A CB  1 
ATOM   1627 C CG  . LEU   A 1 240 ? -16.437 -18.109 -19.302 1.00 40.31 ? 240 LEU   A CG  1 
ATOM   1628 C CD1 . LEU   A 1 240 ? -17.483 -19.203 -19.234 1.00 38.29 ? 240 LEU   A CD1 1 
ATOM   1629 C CD2 . LEU   A 1 240 ? -15.047 -18.675 -19.080 1.00 38.59 ? 240 LEU   A CD2 1 
ATOM   1630 N N   . ALA   A 1 241 ? -16.850 -14.942 -22.580 1.00 42.16 ? 241 ALA   A N   1 
ATOM   1631 C CA  . ALA   A 1 241 ? -17.084 -14.420 -23.922 1.00 43.53 ? 241 ALA   A CA  1 
ATOM   1632 C C   . ALA   A 1 241 ? -16.002 -13.429 -24.327 1.00 41.50 ? 241 ALA   A C   1 
ATOM   1633 O O   . ALA   A 1 241 ? -15.574 -13.407 -25.487 1.00 43.98 ? 241 ALA   A O   1 
ATOM   1634 C CB  . ALA   A 1 241 ? -18.465 -13.767 -23.996 1.00 42.50 ? 241 ALA   A CB  1 
ATOM   1635 N N   . LEU   A 1 242 ? -15.545 -12.599 -23.387 1.00 40.26 ? 242 LEU   A N   1 
ATOM   1636 C CA  . LEU   A 1 242 ? -14.505 -11.629 -23.710 1.00 41.63 ? 242 LEU   A CA  1 
ATOM   1637 C C   . LEU   A 1 242 ? -13.173 -12.323 -23.969 1.00 42.32 ? 242 LEU   A C   1 
ATOM   1638 O O   . LEU   A 1 242 ? -12.516 -12.069 -24.984 1.00 40.93 ? 242 LEU   A O   1 
ATOM   1639 C CB  . LEU   A 1 242 ? -14.370 -10.605 -22.583 1.00 43.05 ? 242 LEU   A CB  1 
ATOM   1640 C CG  . LEU   A 1 242 ? -13.212 -9.616  -22.747 1.00 43.17 ? 242 LEU   A CG  1 
ATOM   1641 C CD1 . LEU   A 1 242 ? -13.350 -8.837  -24.046 1.00 41.35 ? 242 LEU   A CD1 1 
ATOM   1642 C CD2 . LEU   A 1 242 ? -13.107 -8.672  -21.556 1.00 43.71 ? 242 LEU   A CD2 1 
ATOM   1643 N N   . ALA   A 1 243 ? -12.760 -13.207 -23.059 1.00 41.20 ? 243 ALA   A N   1 
ATOM   1644 C CA  . ALA   A 1 243 ? -11.505 -13.930 -23.233 1.00 38.91 ? 243 ALA   A CA  1 
ATOM   1645 C C   . ALA   A 1 243 ? -11.511 -14.765 -24.505 1.00 38.78 ? 243 ALA   A C   1 
ATOM   1646 O O   . ALA   A 1 243 ? -10.466 -14.922 -25.148 1.00 36.15 ? 243 ALA   A O   1 
ATOM   1647 C CB  . ALA   A 1 243 ? -11.233 -14.812 -22.010 1.00 36.30 ? 243 ALA   A CB  1 
ATOM   1648 N N   . LEU   A 1 244 ? -12.673 -15.297 -24.891 1.00 39.21 ? 244 LEU   A N   1 
ATOM   1649 C CA  . LEU   A 1 244 ? -12.751 -16.066 -26.129 1.00 40.46 ? 244 LEU   A CA  1 
ATOM   1650 C C   . LEU   A 1 244 ? -12.546 -15.176 -27.350 1.00 39.79 ? 244 LEU   A C   1 
ATOM   1651 O O   . LEU   A 1 244 ? -11.838 -15.554 -28.292 1.00 40.98 ? 244 LEU   A O   1 
ATOM   1652 C CB  . LEU   A 1 244 ? -14.095 -16.788 -26.219 1.00 39.38 ? 244 LEU   A CB  1 
ATOM   1653 C CG  . LEU   A 1 244 ? -14.284 -17.701 -27.439 1.00 41.30 ? 244 LEU   A CG  1 
ATOM   1654 C CD1 . LEU   A 1 244 ? -13.300 -18.856 -27.396 1.00 41.37 ? 244 LEU   A CD1 1 
ATOM   1655 C CD2 . LEU   A 1 244 ? -15.715 -18.213 -27.527 1.00 38.73 ? 244 LEU   A CD2 1 
ATOM   1656 N N   . ASP   A 1 245 ? -13.154 -13.987 -27.349 1.00 38.66 ? 245 ASP   A N   1 
ATOM   1657 C CA  . ASP   A 1 245 ? -12.960 -13.059 -28.458 1.00 40.05 ? 245 ASP   A CA  1 
ATOM   1658 C C   . ASP   A 1 245 ? -11.521 -12.570 -28.531 1.00 40.72 ? 245 ASP   A C   1 
ATOM   1659 O O   . ASP   A 1 245 ? -11.028 -12.245 -29.617 1.00 43.10 ? 245 ASP   A O   1 
ATOM   1660 C CB  . ASP   A 1 245 ? -13.914 -11.870 -28.329 1.00 38.28 ? 245 ASP   A CB  1 
ATOM   1661 C CG  . ASP   A 1 245 ? -15.356 -12.244 -28.605 1.00 41.61 ? 245 ASP   A CG  1 
ATOM   1662 O OD1 . ASP   A 1 245 ? -15.585 -13.282 -29.261 1.00 44.34 ? 245 ASP   A OD1 1 
ATOM   1663 O OD2 . ASP   A 1 245 ? -16.259 -11.497 -28.172 1.00 45.14 ? 245 ASP   A OD2 1 
ATOM   1664 N N   . ILE   A 1 246 ? -10.830 -12.517 -27.392 1.00 41.49 ? 246 ILE   A N   1 
ATOM   1665 C CA  . ILE   A 1 246 ? -9.447  -12.054 -27.381 1.00 39.24 ? 246 ILE   A CA  1 
ATOM   1666 C C   . ILE   A 1 246 ? -8.504  -13.134 -27.902 1.00 38.02 ? 246 ILE   A C   1 
ATOM   1667 O O   . ILE   A 1 246 ? -7.461  -12.825 -28.493 1.00 39.29 ? 246 ILE   A O   1 
ATOM   1668 C CB  . ILE   A 1 246 ? -9.070  -11.598 -25.957 1.00 39.12 ? 246 ILE   A CB  1 
ATOM   1669 C CG1 . ILE   A 1 246 ? -9.897  -10.375 -25.552 1.00 39.53 ? 246 ILE   A CG1 1 
ATOM   1670 C CG2 . ILE   A 1 246 ? -7.584  -11.285 -25.849 1.00 38.83 ? 246 ILE   A CG2 1 
ATOM   1671 C CD1 . ILE   A 1 246 ? -9.664  -9.928  -24.127 1.00 39.52 ? 246 ILE   A CD1 1 
ATOM   1672 N N   . THR   A 1 247 ? -8.858  -14.409 -27.724 1.00 36.10 ? 247 THR   A N   1 
ATOM   1673 C CA  . THR   A 1 247 ? -7.918  -15.505 -27.922 1.00 37.33 ? 247 THR   A CA  1 
ATOM   1674 C C   . THR   A 1 247 ? -8.176  -16.361 -29.155 1.00 41.70 ? 247 THR   A C   1 
ATOM   1675 O O   . THR   A 1 247 ? -7.248  -17.033 -29.617 1.00 41.42 ? 247 THR   A O   1 
ATOM   1676 C CB  . THR   A 1 247 ? -7.914  -16.426 -26.693 1.00 40.38 ? 247 THR   A CB  1 
ATOM   1677 O OG1 . THR   A 1 247 ? -9.259  -16.804 -26.377 1.00 41.08 ? 247 THR   A OG1 1 
ATOM   1678 C CG2 . THR   A 1 247 ? -7.301  -15.718 -25.496 1.00 36.87 ? 247 THR   A CG2 1 
ATOM   1679 N N   . SER   A 1 248 ? -9.393  -16.365 -29.693 1.00 40.39 ? 248 SER   A N   1 
ATOM   1680 C CA  . SER   A 1 248 ? -9.704  -17.254 -30.804 1.00 41.53 ? 248 SER   A CA  1 
ATOM   1681 C C   . SER   A 1 248 ? -8.908  -16.871 -32.048 1.00 40.36 ? 248 SER   A C   1 
ATOM   1682 O O   . SER   A 1 248 ? -8.488  -15.722 -32.217 1.00 42.10 ? 248 SER   A O   1 
ATOM   1683 C CB  . SER   A 1 248 ? -11.202 -17.227 -31.109 1.00 40.74 ? 248 SER   A CB  1 
ATOM   1684 O OG  . SER   A 1 248 ? -11.630 -15.927 -31.475 1.00 40.85 ? 248 SER   A OG  1 
ATOM   1685 N N   . LYS   A 1 249 ? -8.695  -17.860 -32.922 1.00 40.74 ? 249 LYS   A N   1 
ATOM   1686 C CA  . LYS   A 1 249 ? -7.950  -17.624 -34.156 1.00 40.46 ? 249 LYS   A CA  1 
ATOM   1687 C C   . LYS   A 1 249 ? -8.599  -16.524 -34.985 1.00 41.27 ? 249 LYS   A C   1 
ATOM   1688 O O   . LYS   A 1 249 ? -7.922  -15.607 -35.463 1.00 39.51 ? 249 LYS   A O   1 
ATOM   1689 C CB  . LYS   A 1 249 ? -7.848  -18.921 -34.962 1.00 38.99 ? 249 LYS   A CB  1 
ATOM   1690 C CG  . LYS   A 1 249 ? -6.885  -19.949 -34.385 1.00 39.79 ? 249 LYS   A CG  1 
ATOM   1691 C CD  . LYS   A 1 249 ? -6.948  -21.261 -35.152 1.00 40.77 ? 249 LYS   A CD  1 
ATOM   1692 C CE  . LYS   A 1 249 ? -5.923  -22.256 -34.625 1.00 39.78 ? 249 LYS   A CE  1 
ATOM   1693 N NZ  . LYS   A 1 249 ? -6.094  -23.619 -35.208 1.00 37.32 ? 249 LYS   A NZ  1 
ATOM   1694 N N   . VAL   A 1 250 ? -9.912  -16.603 -35.169 1.00 42.03 ? 250 VAL   A N   1 
ATOM   1695 C CA  . VAL   A 1 250 ? -10.675 -15.523 -35.793 1.00 41.19 ? 250 VAL   A CA  1 
ATOM   1696 C C   . VAL   A 1 250 ? -11.880 -15.234 -34.909 1.00 41.94 ? 250 VAL   A C   1 
ATOM   1697 O O   . VAL   A 1 250 ? -12.283 -16.078 -34.092 1.00 44.27 ? 250 VAL   A O   1 
ATOM   1698 C CB  . VAL   A 1 250 ? -11.110 -15.884 -37.233 1.00 41.06 ? 250 VAL   A CB  1 
ATOM   1699 C CG1 . VAL   A 1 250 ? -9.896  -16.195 -38.098 1.00 40.51 ? 250 VAL   A CG1 1 
ATOM   1700 C CG2 . VAL   A 1 250 ? -12.093 -17.048 -37.223 1.00 36.52 ? 250 VAL   A CG2 1 
ATOM   1701 N N   . PRO   A 1 251 ? -12.457 -14.038 -35.021 1.00 41.97 ? 251 PRO   A N   1 
ATOM   1702 C CA  . PRO   A 1 251 ? -13.683 -13.742 -34.265 1.00 41.27 ? 251 PRO   A CA  1 
ATOM   1703 C C   . PRO   A 1 251 ? -14.788 -14.731 -34.603 1.00 40.88 ? 251 PRO   A C   1 
ATOM   1704 O O   . PRO   A 1 251 ? -15.218 -14.847 -35.754 1.00 42.92 ? 251 PRO   A O   1 
ATOM   1705 C CB  . PRO   A 1 251 ? -14.030 -12.317 -34.707 1.00 37.01 ? 251 PRO   A CB  1 
ATOM   1706 C CG  . PRO   A 1 251 ? -12.708 -11.717 -35.077 1.00 41.87 ? 251 PRO   A CG  1 
ATOM   1707 C CD  . PRO   A 1 251 ? -11.927 -12.840 -35.700 1.00 40.55 ? 251 PRO   A CD  1 
ATOM   1708 N N   . LEU   A 1 252 ? -15.240 -15.454 -33.586 1.00 41.07 ? 252 LEU   A N   1 
ATOM   1709 C CA  . LEU   A 1 252 ? -16.278 -16.456 -33.751 1.00 43.23 ? 252 LEU   A CA  1 
ATOM   1710 C C   . LEU   A 1 252 ? -17.659 -15.804 -33.758 1.00 44.20 ? 252 LEU   A C   1 
ATOM   1711 O O   . LEU   A 1 252 ? -17.837 -14.703 -33.233 1.00 41.98 ? 252 LEU   A O   1 
ATOM   1712 C CB  . LEU   A 1 252 ? -16.174 -17.494 -32.637 1.00 42.77 ? 252 LEU   A CB  1 
ATOM   1713 C CG  . LEU   A 1 252 ? -15.016 -18.486 -32.783 1.00 45.01 ? 252 LEU   A CG  1 
ATOM   1714 C CD1 . LEU   A 1 252 ? -14.986 -19.483 -31.634 1.00 44.25 ? 252 LEU   A CD1 1 
ATOM   1715 C CD2 . LEU   A 1 252 ? -15.108 -19.208 -34.121 1.00 41.98 ? 252 LEU   A CD2 1 
ATOM   1716 N N   . PRO   A 1 253 ? -18.651 -16.461 -34.362 1.00 42.20 ? 253 PRO   A N   1 
ATOM   1717 C CA  . PRO   A 1 253 ? -19.983 -15.849 -34.470 1.00 43.05 ? 253 PRO   A CA  1 
ATOM   1718 C C   . PRO   A 1 253 ? -20.589 -15.558 -33.104 1.00 41.52 ? 253 PRO   A C   1 
ATOM   1719 O O   . PRO   A 1 253 ? -20.664 -16.432 -32.238 1.00 43.87 ? 253 PRO   A O   1 
ATOM   1720 C CB  . PRO   A 1 253 ? -20.793 -16.903 -35.234 1.00 45.28 ? 253 PRO   A CB  1 
ATOM   1721 C CG  . PRO   A 1 253 ? -19.784 -17.686 -35.988 1.00 43.72 ? 253 PRO   A CG  1 
ATOM   1722 C CD  . PRO   A 1 253 ? -18.567 -17.729 -35.110 1.00 42.03 ? 253 PRO   A CD  1 
ATOM   1723 N N   . GLN   A 1 254 ? -21.023 -14.314 -32.920 1.00 41.59 ? 254 GLN   A N   1 
ATOM   1724 C CA  . GLN   A 1 254 ? -21.684 -13.927 -31.683 1.00 38.02 ? 254 GLN   A CA  1 
ATOM   1725 C C   . GLN   A 1 254 ? -23.073 -14.547 -31.603 1.00 40.63 ? 254 GLN   A C   1 
ATOM   1726 O O   . GLN   A 1 254 ? -23.710 -14.839 -32.620 1.00 44.11 ? 254 GLN   A O   1 
ATOM   1727 C CB  . GLN   A 1 254 ? -21.790 -12.406 -31.583 1.00 37.41 ? 254 GLN   A CB  1 
ATOM   1728 C CG  . GLN   A 1 254 ? -20.455 -11.687 -31.530 1.00 37.58 ? 254 GLN   A CG  1 
ATOM   1729 C CD  . GLN   A 1 254 ? -19.736 -11.879 -30.210 1.00 39.78 ? 254 GLN   A CD  1 
ATOM   1730 O OE1 . GLN   A 1 254 ? -20.359 -12.134 -29.180 1.00 42.08 ? 254 GLN   A OE1 1 
ATOM   1731 N NE2 . GLN   A 1 254 ? -18.415 -11.755 -30.234 1.00 37.82 ? 254 GLN   A NE2 1 
ATOM   1732 N N   . SER   A 1 255 ? -23.549 -14.736 -30.376 1.00 43.17 ? 255 SER   A N   1 
ATOM   1733 C CA  . SER   A 1 255 ? -24.846 -15.359 -30.164 1.00 43.45 ? 255 SER   A CA  1 
ATOM   1734 C C   . SER   A 1 255 ? -25.965 -14.345 -30.354 1.00 47.45 ? 255 SER   A C   1 
ATOM   1735 O O   . SER   A 1 255 ? -25.871 -13.200 -29.903 1.00 46.96 ? 255 SER   A O   1 
ATOM   1736 C CB  . SER   A 1 255 ? -24.927 -15.969 -28.766 1.00 46.38 ? 255 SER   A CB  1 
ATOM   1737 O OG  . SER   A 1 255 ? -26.201 -16.551 -28.541 1.00 42.55 ? 255 SER   A OG  1 
ATOM   1738 N N   . ARG   A 1 256 ? -27.026 -14.776 -31.033 1.00 49.08 ? 256 ARG   A N   1 
ATOM   1739 C CA  . ARG   A 1 256 ? -28.231 -13.977 -31.196 1.00 51.32 ? 256 ARG   A CA  1 
ATOM   1740 C C   . ARG   A 1 256 ? -29.385 -14.489 -30.346 1.00 51.04 ? 256 ARG   A C   1 
ATOM   1741 O O   . ARG   A 1 256 ? -30.486 -13.934 -30.421 1.00 52.01 ? 256 ARG   A O   1 
ATOM   1742 C CB  . ARG   A 1 256 ? -28.644 -13.934 -32.673 1.00 53.23 ? 256 ARG   A CB  1 
ATOM   1743 C CG  . ARG   A 1 256 ? -27.472 -13.791 -33.636 1.00 55.79 ? 256 ARG   A CG  1 
ATOM   1744 C CD  . ARG   A 1 256 ? -27.806 -12.912 -34.840 1.00 66.27 ? 256 ARG   A CD  1 
ATOM   1745 N NE  . ARG   A 1 256 ? -28.970 -13.382 -35.584 1.00 73.35 ? 256 ARG   A NE  1 
ATOM   1746 C CZ  . ARG   A 1 256 ? -30.164 -12.806 -35.552 1.00 76.00 ? 256 ARG   A CZ  1 
ATOM   1747 N NH1 . ARG   A 1 256 ? -30.392 -11.728 -34.821 1.00 72.41 ? 256 ARG   A NH1 1 
ATOM   1748 N NH2 . ARG   A 1 256 ? -31.154 -13.325 -36.274 1.00 78.92 ? 256 ARG   A NH2 1 
ATOM   1749 N N   . ILE   A 1 257 ? -29.162 -15.530 -29.544 1.00 51.00 ? 257 ILE   A N   1 
ATOM   1750 C CA  . ILE   A 1 257 ? -30.178 -16.072 -28.649 1.00 48.61 ? 257 ILE   A CA  1 
ATOM   1751 C C   . ILE   A 1 257 ? -30.551 -15.012 -27.622 1.00 49.06 ? 257 ILE   A C   1 
ATOM   1752 O O   . ILE   A 1 257 ? -29.781 -14.729 -26.697 1.00 47.60 ? 257 ILE   A O   1 
ATOM   1753 C CB  . ILE   A 1 257 ? -29.681 -17.358 -27.963 1.00 48.61 ? 257 ILE   A CB  1 
ATOM   1754 C CG1 . ILE   A 1 257 ? -29.329 -18.414 -29.012 1.00 49.19 ? 257 ILE   A CG1 1 
ATOM   1755 C CG2 . ILE   A 1 257 ? -30.720 -17.883 -26.985 1.00 47.70 ? 257 ILE   A CG2 1 
ATOM   1756 C CD1 . ILE   A 1 257 ? -28.788 -19.700 -28.433 1.00 46.01 ? 257 ILE   A CD1 1 
ATOM   1757 N N   . ALA   A 1 258 ? -31.733 -14.416 -27.780 1.00 51.36 ? 258 ALA   A N   1 
ATOM   1758 C CA  . ALA   A 1 258 ? -32.145 -13.345 -26.881 1.00 49.67 ? 258 ALA   A CA  1 
ATOM   1759 C C   . ALA   A 1 258 ? -32.643 -13.887 -25.546 1.00 48.60 ? 258 ALA   A C   1 
ATOM   1760 O O   . ALA   A 1 258 ? -32.322 -13.328 -24.491 1.00 45.22 ? 258 ALA   A O   1 
ATOM   1761 C CB  . ALA   A 1 258 ? -33.218 -12.484 -27.548 1.00 50.68 ? 258 ALA   A CB  1 
ATOM   1762 N N   . ASN   A 1 259 ? -33.423 -14.964 -25.568 1.00 48.86 ? 259 ASN   A N   1 
ATOM   1763 C CA  . ASN   A 1 259 ? -33.947 -15.563 -24.344 1.00 50.22 ? 259 ASN   A CA  1 
ATOM   1764 C C   . ASN   A 1 259 ? -34.086 -17.067 -24.561 1.00 50.85 ? 259 ASN   A C   1 
ATOM   1765 O O   . ASN   A 1 259 ? -33.595 -17.618 -25.551 1.00 48.15 ? 259 ASN   A O   1 
ATOM   1766 C CB  . ASN   A 1 259 ? -35.275 -14.910 -23.937 1.00 49.62 ? 259 ASN   A CB  1 
ATOM   1767 C CG  . ASN   A 1 259 ? -36.284 -14.893 -25.065 1.00 46.13 ? 259 ASN   A CG  1 
ATOM   1768 O OD1 . ASN   A 1 259 ? -36.804 -15.936 -25.465 1.00 46.29 ? 259 ASN   A OD1 1 
ATOM   1769 N ND2 . ASN   A 1 259 ? -36.577 -13.703 -25.578 1.00 49.16 ? 259 ASN   A ND2 1 
ATOM   1770 N N   . LEU   A 1 260 ? -34.773 -17.732 -23.630 1.00 49.81 ? 260 LEU   A N   1 
ATOM   1771 C CA  . LEU   A 1 260 ? -34.858 -19.187 -23.612 1.00 50.59 ? 260 LEU   A CA  1 
ATOM   1772 C C   . LEU   A 1 260 ? -36.084 -19.744 -24.326 1.00 48.86 ? 260 LEU   A C   1 
ATOM   1773 O O   . LEU   A 1 260 ? -36.138 -20.954 -24.568 1.00 48.15 ? 260 LEU   A O   1 
ATOM   1774 C CB  . LEU   A 1 260 ? -34.852 -19.696 -22.165 1.00 47.89 ? 260 LEU   A CB  1 
ATOM   1775 C CG  . LEU   A 1 260 ? -33.533 -19.616 -21.393 1.00 48.48 ? 260 LEU   A CG  1 
ATOM   1776 C CD1 . LEU   A 1 260 ? -33.748 -19.972 -19.930 1.00 52.99 ? 260 LEU   A CD1 1 
ATOM   1777 C CD2 . LEU   A 1 260 ? -32.490 -20.529 -22.017 1.00 49.12 ? 260 LEU   A CD2 1 
ATOM   1778 N N   . SER   A 1 261 ? -37.060 -18.907 -24.667 1.00 48.60 ? 261 SER   A N   1 
ATOM   1779 C CA  . SER   A 1 261 ? -38.269 -19.402 -25.310 1.00 54.00 ? 261 SER   A CA  1 
ATOM   1780 C C   . SER   A 1 261 ? -37.954 -19.946 -26.698 1.00 51.49 ? 261 SER   A C   1 
ATOM   1781 O O   . SER   A 1 261 ? -37.188 -19.350 -27.459 1.00 52.00 ? 261 SER   A O   1 
ATOM   1782 C CB  . SER   A 1 261 ? -39.315 -18.293 -25.404 1.00 53.30 ? 261 SER   A CB  1 
ATOM   1783 O OG  . SER   A 1 261 ? -38.948 -17.326 -26.372 1.00 53.69 ? 261 SER   A OG  1 
ATOM   1784 N N   . GLY   A 1 262 ? -38.552 -21.092 -27.024 1.00 50.03 ? 262 GLY   A N   1 
ATOM   1785 C CA  . GLY   A 1 262 ? -38.291 -21.770 -28.273 1.00 49.29 ? 262 GLY   A CA  1 
ATOM   1786 C C   . GLY   A 1 262 ? -37.021 -22.591 -28.302 1.00 51.82 ? 262 GLY   A C   1 
ATOM   1787 O O   . GLY   A 1 262 ? -36.853 -23.410 -29.214 1.00 54.61 ? 262 GLY   A O   1 
ATOM   1788 N N   . LEU   A 1 263 ? -36.124 -22.404 -27.336 1.00 50.06 ? 263 LEU   A N   1 
ATOM   1789 C CA  . LEU   A 1 263 ? -34.874 -23.151 -27.318 1.00 50.00 ? 263 LEU   A CA  1 
ATOM   1790 C C   . LEU   A 1 263 ? -35.151 -24.638 -27.137 1.00 48.61 ? 263 LEU   A C   1 
ATOM   1791 O O   . LEU   A 1 263 ? -35.935 -25.038 -26.271 1.00 47.22 ? 263 LEU   A O   1 
ATOM   1792 C CB  . LEU   A 1 263 ? -33.970 -22.636 -26.196 1.00 51.65 ? 263 LEU   A CB  1 
ATOM   1793 C CG  . LEU   A 1 263 ? -32.467 -22.890 -26.323 1.00 51.71 ? 263 LEU   A CG  1 
ATOM   1794 C CD1 . LEU   A 1 263 ? -31.880 -22.078 -27.469 1.00 47.39 ? 263 LEU   A CD1 1 
ATOM   1795 C CD2 . LEU   A 1 263 ? -31.754 -22.574 -25.018 1.00 46.90 ? 263 LEU   A CD2 1 
ATOM   1796 N N   . ARG   A 1 264 ? -34.508 -25.456 -27.964 1.00 50.07 ? 264 ARG   A N   1 
ATOM   1797 C CA  . ARG   A 1 264 ? -34.702 -26.899 -27.954 1.00 49.09 ? 264 ARG   A CA  1 
ATOM   1798 C C   . ARG   A 1 264 ? -33.556 -27.551 -27.193 1.00 46.87 ? 264 ARG   A C   1 
ATOM   1799 O O   . ARG   A 1 264 ? -32.385 -27.342 -27.529 1.00 49.94 ? 264 ARG   A O   1 
ATOM   1800 C CB  . ARG   A 1 264 ? -34.782 -27.436 -29.381 1.00 45.30 ? 264 ARG   A CB  1 
ATOM   1801 C CG  . ARG   A 1 264 ? -35.808 -26.726 -30.243 1.00 48.96 ? 264 ARG   A CG  1 
ATOM   1802 C CD  . ARG   A 1 264 ? -35.509 -26.940 -31.712 1.00 48.26 ? 264 ARG   A CD  1 
ATOM   1803 N NE  . ARG   A 1 264 ? -34.258 -26.301 -32.103 1.00 49.51 ? 264 ARG   A NE  1 
ATOM   1804 C CZ  . ARG   A 1 264 ? -33.632 -26.515 -33.252 1.00 48.93 ? 264 ARG   A CZ  1 
ATOM   1805 N NH1 . ARG   A 1 264 ? -34.097 -27.376 -34.140 1.00 49.99 ? 264 ARG   A NH1 1 
ATOM   1806 N NH2 . ARG   A 1 264 ? -32.512 -25.847 -33.515 1.00 45.09 ? 264 ARG   A NH2 1 
ATOM   1807 N N   . ILE   A 1 265 ? -33.892 -28.345 -26.180 1.00 45.36 ? 265 ILE   A N   1 
ATOM   1808 C CA  . ILE   A 1 265 ? -32.912 -28.947 -25.285 1.00 45.61 ? 265 ILE   A CA  1 
ATOM   1809 C C   . ILE   A 1 265 ? -33.060 -30.461 -25.332 1.00 45.43 ? 265 ILE   A C   1 
ATOM   1810 O O   . ILE   A 1 265 ? -34.181 -30.983 -25.281 1.00 46.57 ? 265 ILE   A O   1 
ATOM   1811 C CB  . ILE   A 1 265 ? -33.075 -28.438 -23.841 1.00 43.78 ? 265 ILE   A CB  1 
ATOM   1812 C CG1 . ILE   A 1 265 ? -32.949 -26.916 -23.776 1.00 46.35 ? 265 ILE   A CG1 1 
ATOM   1813 C CG2 . ILE   A 1 265 ? -32.051 -29.090 -22.923 1.00 45.10 ? 265 ILE   A CG2 1 
ATOM   1814 C CD1 . ILE   A 1 265 ? -33.166 -26.352 -22.386 1.00 44.99 ? 265 ILE   A CD1 1 
ATOM   1815 N N   . LEU   A 1 266 ? -31.931 -31.160 -25.425 1.00 43.78 ? 266 LEU   A N   1 
ATOM   1816 C CA  . LEU   A 1 266 ? -31.878 -32.600 -25.214 1.00 42.26 ? 266 LEU   A CA  1 
ATOM   1817 C C   . LEU   A 1 266 ? -31.325 -32.852 -23.819 1.00 46.99 ? 266 LEU   A C   1 
ATOM   1818 O O   . LEU   A 1 266 ? -30.188 -32.475 -23.519 1.00 43.08 ? 266 LEU   A O   1 
ATOM   1819 C CB  . LEU   A 1 266 ? -31.018 -33.290 -26.271 1.00 42.26 ? 266 LEU   A CB  1 
ATOM   1820 C CG  . LEU   A 1 266 ? -30.899 -34.810 -26.114 1.00 42.01 ? 266 LEU   A CG  1 
ATOM   1821 C CD1 . LEU   A 1 266 ? -32.275 -35.460 -26.149 1.00 42.77 ? 266 LEU   A CD1 1 
ATOM   1822 C CD2 . LEU   A 1 266 ? -29.994 -35.408 -27.185 1.00 41.62 ? 266 LEU   A CD2 1 
ATOM   1823 N N   . LEU   A 1 267 ? -32.132 -33.477 -22.972 1.00 46.48 ? 267 LEU   A N   1 
ATOM   1824 C CA  . LEU   A 1 267 ? -31.789 -33.689 -21.570 1.00 42.16 ? 267 LEU   A CA  1 
ATOM   1825 C C   . LEU   A 1 267 ? -31.317 -35.127 -21.386 1.00 44.07 ? 267 LEU   A C   1 
ATOM   1826 O O   . LEU   A 1 267 ? -32.088 -36.073 -21.575 1.00 45.68 ? 267 LEU   A O   1 
ATOM   1827 C CB  . LEU   A 1 267 ? -32.980 -33.379 -20.669 1.00 45.56 ? 267 LEU   A CB  1 
ATOM   1828 C CG  . LEU   A 1 267 ? -32.769 -33.628 -19.177 1.00 47.95 ? 267 LEU   A CG  1 
ATOM   1829 C CD1 . LEU   A 1 267 ? -31.558 -32.863 -18.679 1.00 46.21 ? 267 LEU   A CD1 1 
ATOM   1830 C CD2 . LEU   A 1 267 ? -34.010 -33.252 -18.383 1.00 45.79 ? 267 LEU   A CD2 1 
ATOM   1831 N N   . LEU   A 1 268 ? -30.048 -35.284 -21.016 1.00 44.22 ? 268 LEU   A N   1 
ATOM   1832 C CA  . LEU   A 1 268 ? -29.441 -36.585 -20.766 1.00 42.90 ? 268 LEU   A CA  1 
ATOM   1833 C C   . LEU   A 1 268 ? -28.995 -36.648 -19.312 1.00 44.17 ? 268 LEU   A C   1 
ATOM   1834 O O   . LEU   A 1 268 ? -28.110 -35.891 -18.896 1.00 44.82 ? 268 LEU   A O   1 
ATOM   1835 C CB  . LEU   A 1 268 ? -28.250 -36.827 -21.698 1.00 43.65 ? 268 LEU   A CB  1 
ATOM   1836 C CG  . LEU   A 1 268 ? -28.472 -36.725 -23.209 1.00 47.16 ? 268 LEU   A CG  1 
ATOM   1837 C CD1 . LEU   A 1 268 ? -27.171 -37.000 -23.951 1.00 45.06 ? 268 LEU   A CD1 1 
ATOM   1838 C CD2 . LEU   A 1 268 ? -29.564 -37.683 -23.659 1.00 45.97 ? 268 LEU   A CD2 1 
ATOM   1839 N N   . THR   A 1 269 ? -29.618 -37.538 -18.538 1.00 41.84 ? 269 THR   A N   1 
ATOM   1840 C CA  . THR   A 1 269 ? -29.200 -37.815 -17.169 1.00 44.61 ? 269 THR   A CA  1 
ATOM   1841 C C   . THR   A 1 269 ? -28.694 -39.241 -17.012 1.00 45.04 ? 269 THR   A C   1 
ATOM   1842 O O   . THR   A 1 269 ? -28.524 -39.711 -15.880 1.00 46.82 ? 269 THR   A O   1 
ATOM   1843 C CB  . THR   A 1 269 ? -30.350 -37.557 -16.192 1.00 40.97 ? 269 THR   A CB  1 
ATOM   1844 O OG1 . THR   A 1 269 ? -31.461 -38.393 -16.533 1.00 45.39 ? 269 THR   A OG1 1 
ATOM   1845 C CG2 . THR   A 1 269 ? -30.780 -36.101 -16.252 1.00 43.13 ? 269 THR   A CG2 1 
ATOM   1846 N N   . ALA   A 1 270 ? -28.460 -39.943 -18.117 1.00 43.44 ? 270 ALA   A N   1 
ATOM   1847 C CA  . ALA   A 1 270 ? -27.945 -41.301 -18.088 1.00 42.17 ? 270 ALA   A CA  1 
ATOM   1848 C C   . ALA   A 1 270 ? -26.970 -41.494 -19.240 1.00 46.48 ? 270 ALA   A C   1 
ATOM   1849 O O   . ALA   A 1 270 ? -27.067 -40.832 -20.278 1.00 48.58 ? 270 ALA   A O   1 
ATOM   1850 C CB  . ALA   A 1 270 ? -29.072 -42.340 -18.170 1.00 39.11 ? 270 ALA   A CB  1 
ATOM   1851 N N   . HIS   A 1 271 ? -26.022 -42.412 -19.039 1.00 47.33 ? 271 HIS   A N   1 
ATOM   1852 C CA  . HIS   A 1 271 ? -25.016 -42.748 -20.030 1.00 47.87 ? 271 HIS   A CA  1 
ATOM   1853 C C   . HIS   A 1 271 ? -24.903 -44.268 -20.048 1.00 49.15 ? 271 HIS   A C   1 
ATOM   1854 O O   . HIS   A 1 271 ? -24.853 -44.895 -18.973 1.00 51.88 ? 271 HIS   A O   1 
ATOM   1855 C CB  . HIS   A 1 271 ? -23.665 -42.109 -19.707 1.00 47.47 ? 271 HIS   A CB  1 
ATOM   1856 C CG  . HIS   A 1 271 ? -22.676 -42.179 -20.829 1.00 48.30 ? 271 HIS   A CG  1 
ATOM   1857 N ND1 . HIS   A 1 271 ? -21.986 -43.329 -21.145 1.00 48.01 ? 271 HIS   A ND1 1 
ATOM   1858 C CD2 . HIS   A 1 271 ? -22.258 -41.236 -21.705 1.00 46.73 ? 271 HIS   A CD2 1 
ATOM   1859 C CE1 . HIS   A 1 271 ? -21.185 -43.092 -22.169 1.00 46.49 ? 271 HIS   A CE1 1 
ATOM   1860 N NE2 . HIS   A 1 271 ? -21.331 -41.829 -22.528 1.00 47.21 ? 271 HIS   A NE2 1 
ATOM   1861 N N   . PRO   A 1 272 ? -24.859 -44.892 -21.229 1.00 49.47 ? 272 PRO   A N   1 
ATOM   1862 C CA  . PRO   A 1 272 ? -24.845 -46.365 -21.286 1.00 48.50 ? 272 PRO   A CA  1 
ATOM   1863 C C   . PRO   A 1 272 ? -23.593 -47.001 -20.703 1.00 53.21 ? 272 PRO   A C   1 
ATOM   1864 O O   . PRO   A 1 272 ? -23.596 -48.218 -20.478 1.00 52.45 ? 272 PRO   A O   1 
ATOM   1865 C CB  . PRO   A 1 272 ? -24.964 -46.659 -22.788 1.00 49.08 ? 272 PRO   A CB  1 
ATOM   1866 C CG  . PRO   A 1 272 ? -24.418 -45.423 -23.449 1.00 46.08 ? 272 PRO   A CG  1 
ATOM   1867 C CD  . PRO   A 1 272 ? -24.851 -44.284 -22.569 1.00 50.08 ? 272 PRO   A CD  1 
ATOM   1868 N N   . GLU   A 1 273 ? -22.541 -46.229 -20.431 1.00 50.91 ? 273 GLU   A N   1 
ATOM   1869 C CA  . GLU   A 1 273 ? -21.279 -46.787 -19.969 1.00 48.23 ? 273 GLU   A CA  1 
ATOM   1870 C C   . GLU   A 1 273 ? -20.820 -46.257 -18.617 1.00 52.94 ? 273 GLU   A C   1 
ATOM   1871 O O   . GLU   A 1 273 ? -19.749 -46.660 -18.149 1.00 52.73 ? 273 GLU   A O   1 
ATOM   1872 C CB  . GLU   A 1 273 ? -20.180 -46.532 -21.010 1.00 47.63 ? 273 GLU   A CB  1 
ATOM   1873 C CG  . GLU   A 1 273 ? -20.528 -47.029 -22.398 1.00 54.49 ? 273 GLU   A CG  1 
ATOM   1874 C CD  . GLU   A 1 273 ? -20.784 -48.520 -22.428 1.00 56.66 ? 273 GLU   A CD  1 
ATOM   1875 O OE1 . GLU   A 1 273 ? -20.020 -49.264 -21.782 1.00 59.50 ? 273 GLU   A OE1 1 
ATOM   1876 O OE2 . GLU   A 1 273 ? -21.747 -48.951 -23.093 1.00 53.76 ? 273 GLU   A OE2 1 
ATOM   1877 N N   . THR   A 1 274 ? -21.582 -45.376 -17.977 1.00 50.02 ? 274 THR   A N   1 
ATOM   1878 C CA  . THR   A 1 274 ? -21.197 -44.846 -16.672 1.00 49.82 ? 274 THR   A CA  1 
ATOM   1879 C C   . THR   A 1 274 ? -22.457 -44.416 -15.929 1.00 48.11 ? 274 THR   A C   1 
ATOM   1880 O O   . THR   A 1 274 ? -23.579 -44.587 -16.420 1.00 50.74 ? 274 THR   A O   1 
ATOM   1881 C CB  . THR   A 1 274 ? -20.190 -43.699 -16.813 1.00 51.30 ? 274 THR   A CB  1 
ATOM   1882 O OG1 . THR   A 1 274 ? -19.870 -43.178 -15.515 1.00 46.05 ? 274 THR   A OG1 1 
ATOM   1883 C CG2 . THR   A 1 274 ? -20.756 -42.594 -17.681 1.00 49.86 ? 274 THR   A CG2 1 
ATOM   1884 N N   . VAL   A 1 275 ? -22.268 -43.851 -14.733 1.00 48.36 ? 275 VAL   A N   1 
ATOM   1885 C CA  . VAL   A 1 275 ? -23.362 -43.572 -13.813 1.00 47.52 ? 275 VAL   A CA  1 
ATOM   1886 C C   . VAL   A 1 275 ? -23.230 -42.157 -13.269 1.00 47.41 ? 275 VAL   A C   1 
ATOM   1887 O O   . VAL   A 1 275 ? -22.199 -41.499 -13.423 1.00 48.08 ? 275 VAL   A O   1 
ATOM   1888 C CB  . VAL   A 1 275 ? -23.404 -44.589 -12.652 1.00 46.52 ? 275 VAL   A CB  1 
ATOM   1889 C CG1 . VAL   A 1 275 ? -23.845 -45.951 -13.155 1.00 43.35 ? 275 VAL   A CG1 1 
ATOM   1890 C CG2 . VAL   A 1 275 ? -22.038 -44.685 -11.988 1.00 45.54 ? 275 VAL   A CG2 1 
ATOM   1891 N N   . ALA   A 1 276 ? -24.295 -41.700 -12.605 1.00 49.23 ? 276 ALA   A N   1 
ATOM   1892 C CA  . ALA   A 1 276 ? -24.360 -40.347 -12.071 1.00 47.72 ? 276 ALA   A CA  1 
ATOM   1893 C C   . ALA   A 1 276 ? -25.013 -40.351 -10.695 1.00 51.98 ? 276 ALA   A C   1 
ATOM   1894 O O   . ALA   A 1 276 ? -25.809 -41.236 -10.369 1.00 55.23 ? 276 ALA   A O   1 
ATOM   1895 C CB  . ALA   A 1 276 ? -25.128 -39.408 -13.014 1.00 46.66 ? 276 ALA   A CB  1 
ATOM   1896 N N   . ASP   A 1 277 ? -24.658 -39.348 -9.888  1.00 53.68 ? 277 ASP   A N   1 
ATOM   1897 C CA  . ASP   A 1 277 ? -25.299 -39.155 -8.594  1.00 53.05 ? 277 ASP   A CA  1 
ATOM   1898 C C   . ASP   A 1 277 ? -26.790 -38.902 -8.776  1.00 50.87 ? 277 ASP   A C   1 
ATOM   1899 O O   . ASP   A 1 277 ? -27.230 -38.364 -9.794  1.00 50.32 ? 277 ASP   A O   1 
ATOM   1900 C CB  . ASP   A 1 277 ? -24.676 -37.969 -7.849  1.00 49.02 ? 277 ASP   A CB  1 
ATOM   1901 C CG  . ASP   A 1 277 ? -23.421 -38.342 -7.077  1.00 56.14 ? 277 ASP   A CG  1 
ATOM   1902 O OD1 . ASP   A 1 277 ? -23.220 -39.541 -6.802  1.00 62.70 ? 277 ASP   A OD1 1 
ATOM   1903 O OD2 . ASP   A 1 277 ? -22.649 -37.423 -6.730  1.00 58.29 ? 277 ASP   A OD2 1 
ATOM   1904 N N   . SER   A 1 278 ? -27.575 -39.301 -7.772  1.00 51.35 ? 278 SER   A N   1 
ATOM   1905 C CA  . SER   A 1 278 ? -28.973 -38.889 -7.738  1.00 53.38 ? 278 SER   A CA  1 
ATOM   1906 C C   . SER   A 1 278 ? -29.098 -37.401 -7.437  1.00 50.52 ? 278 SER   A C   1 
ATOM   1907 O O   . SER   A 1 278 ? -30.075 -36.765 -7.849  1.00 50.12 ? 278 SER   A O   1 
ATOM   1908 C CB  . SER   A 1 278 ? -29.746 -39.712 -6.708  1.00 52.01 ? 278 SER   A CB  1 
ATOM   1909 O OG  . SER   A 1 278 ? -29.122 -39.654 -5.438  1.00 55.71 ? 278 SER   A OG  1 
ATOM   1910 N N   . ALA   A 1 279 ? -28.125 -36.835 -6.719  1.00 48.36 ? 279 ALA   A N   1 
ATOM   1911 C CA  . ALA   A 1 279 ? -28.085 -35.390 -6.533  1.00 48.32 ? 279 ALA   A CA  1 
ATOM   1912 C C   . ALA   A 1 279 ? -27.697 -34.682 -7.827  1.00 49.92 ? 279 ALA   A C   1 
ATOM   1913 O O   . ALA   A 1 279 ? -28.220 -33.605 -8.131  1.00 49.26 ? 279 ALA   A O   1 
ATOM   1914 C CB  . ALA   A 1 279 ? -27.113 -35.032 -5.409  1.00 45.16 ? 279 ALA   A CB  1 
ATOM   1915 N N   . THR   A 1 280 ? -26.781 -35.272 -8.601  1.00 46.77 ? 280 THR   A N   1 
ATOM   1916 C CA  . THR   A 1 280 ? -26.416 -34.689 -9.888  1.00 44.21 ? 280 THR   A CA  1 
ATOM   1917 C C   . THR   A 1 280 ? -27.560 -34.806 -10.888 1.00 47.31 ? 280 THR   A C   1 
ATOM   1918 O O   . THR   A 1 280 ? -27.853 -33.853 -11.619 1.00 45.38 ? 280 THR   A O   1 
ATOM   1919 C CB  . THR   A 1 280 ? -25.155 -35.364 -10.435 1.00 46.60 ? 280 THR   A CB  1 
ATOM   1920 O OG1 . THR   A 1 280 ? -24.033 -35.056 -9.596  1.00 47.81 ? 280 THR   A OG1 1 
ATOM   1921 C CG2 . THR   A 1 280 ? -24.865 -34.888 -11.847 1.00 44.26 ? 280 THR   A CG2 1 
ATOM   1922 N N   . ILE   A 1 281 ? -28.222 -35.966 -10.925 1.00 45.78 ? 281 ILE   A N   1 
ATOM   1923 C CA  . ILE   A 1 281 ? -29.327 -36.176 -11.859 1.00 48.99 ? 281 ILE   A CA  1 
ATOM   1924 C C   . ILE   A 1 281 ? -30.442 -35.166 -11.607 1.00 48.04 ? 281 ILE   A C   1 
ATOM   1925 O O   . ILE   A 1 281 ? -30.984 -34.568 -12.546 1.00 51.63 ? 281 ILE   A O   1 
ATOM   1926 C CB  . ILE   A 1 281 ? -29.834 -37.629 -11.758 1.00 47.98 ? 281 ILE   A CB  1 
ATOM   1927 C CG1 . ILE   A 1 281 ? -28.861 -38.593 -12.444 1.00 45.89 ? 281 ILE   A CG1 1 
ATOM   1928 C CG2 . ILE   A 1 281 ? -31.230 -37.762 -12.351 1.00 45.84 ? 281 ILE   A CG2 1 
ATOM   1929 C CD1 . ILE   A 1 281 ? -29.182 -40.058 -12.209 1.00 48.85 ? 281 ILE   A CD1 1 
ATOM   1930 N N   . SER   A 1 282 ? -30.789 -34.946 -10.333 1.00 46.90 ? 282 SER   A N   1 
ATOM   1931 C CA  . SER   A 1 282 ? -31.846 -33.995 -10.007 1.00 51.01 ? 282 SER   A CA  1 
ATOM   1932 C C   . SER   A 1 282 ? -31.421 -32.559 -10.288 1.00 50.33 ? 282 SER   A C   1 
ATOM   1933 O O   . SER   A 1 282 ? -32.256 -31.736 -10.688 1.00 52.50 ? 282 SER   A O   1 
ATOM   1934 C CB  . SER   A 1 282 ? -32.262 -34.159 -8.545  1.00 44.99 ? 282 SER   A CB  1 
ATOM   1935 O OG  . SER   A 1 282 ? -31.153 -33.978 -7.678  1.00 51.70 ? 282 SER   A OG  1 
ATOM   1936 N N   . ALA   A 1 283 ? -30.141 -32.237 -10.085 1.00 49.08 ? 283 ALA   A N   1 
ATOM   1937 C CA  . ALA   A 1 283 ? -29.672 -30.885 -10.371 1.00 47.86 ? 283 ALA   A CA  1 
ATOM   1938 C C   . ALA   A 1 283 ? -29.766 -30.573 -11.859 1.00 49.72 ? 283 ALA   A C   1 
ATOM   1939 O O   . ALA   A 1 283 ? -30.174 -29.472 -12.248 1.00 50.89 ? 283 ALA   A O   1 
ATOM   1940 C CB  . ALA   A 1 283 ? -28.238 -30.712 -9.876  1.00 47.29 ? 283 ALA   A CB  1 
ATOM   1941 N N   . VAL   A 1 284 ? -29.397 -31.535 -12.707 1.00 49.47 ? 284 VAL   A N   1 
ATOM   1942 C CA  . VAL   A 1 284 ? -29.515 -31.338 -14.147 1.00 48.97 ? 284 VAL   A CA  1 
ATOM   1943 C C   . VAL   A 1 284 ? -30.981 -31.262 -14.552 1.00 48.39 ? 284 VAL   A C   1 
ATOM   1944 O O   . VAL   A 1 284 ? -31.358 -30.471 -15.426 1.00 48.00 ? 284 VAL   A O   1 
ATOM   1945 C CB  . VAL   A 1 284 ? -28.770 -32.455 -14.902 1.00 43.40 ? 284 VAL   A CB  1 
ATOM   1946 C CG1 . VAL   A 1 284 ? -28.870 -32.239 -16.399 1.00 47.63 ? 284 VAL   A CG1 1 
ATOM   1947 C CG2 . VAL   A 1 284 ? -27.314 -32.501 -14.476 1.00 44.83 ? 284 VAL   A CG2 1 
ATOM   1948 N N   . GLU   A 1 285 ? -31.832 -32.075 -13.921 1.00 48.30 ? 285 GLU   A N   1 
ATOM   1949 C CA  . GLU   A 1 285 ? -33.263 -32.002 -14.193 1.00 50.14 ? 285 GLU   A CA  1 
ATOM   1950 C C   . GLU   A 1 285 ? -33.853 -30.686 -13.702 1.00 50.93 ? 285 GLU   A C   1 
ATOM   1951 O O   . GLU   A 1 285 ? -34.772 -30.140 -14.323 1.00 50.63 ? 285 GLU   A O   1 
ATOM   1952 C CB  . GLU   A 1 285 ? -33.978 -33.189 -13.549 1.00 50.90 ? 285 GLU   A CB  1 
ATOM   1953 C CG  . GLU   A 1 285 ? -33.808 -34.502 -14.302 1.00 51.86 ? 285 GLU   A CG  1 
ATOM   1954 C CD  . GLU   A 1 285 ? -34.364 -35.686 -13.538 1.00 55.86 ? 285 GLU   A CD  1 
ATOM   1955 O OE1 . GLU   A 1 285 ? -34.026 -35.832 -12.346 1.00 57.52 ? 285 GLU   A OE1 1 
ATOM   1956 O OE2 . GLU   A 1 285 ? -35.144 -36.465 -14.124 1.00 58.20 ? 285 GLU   A OE2 1 
ATOM   1957 N N   . ARG   A 1 286 ? -33.343 -30.162 -12.584 1.00 48.38 ? 286 ARG   A N   1 
ATOM   1958 C CA  . ARG   A 1 286 ? -33.795 -28.860 -12.108 1.00 47.45 ? 286 ARG   A CA  1 
ATOM   1959 C C   . ARG   A 1 286 ? -33.399 -27.749 -13.070 1.00 50.28 ? 286 ARG   A C   1 
ATOM   1960 O O   . ARG   A 1 286 ? -34.132 -26.764 -13.213 1.00 51.16 ? 286 ARG   A O   1 
ATOM   1961 C CB  . ARG   A 1 286 ? -33.234 -28.578 -10.711 1.00 51.15 ? 286 ARG   A CB  1 
ATOM   1962 C CG  . ARG   A 1 286 ? -33.766 -27.299 -10.080 1.00 54.31 ? 286 ARG   A CG  1 
ATOM   1963 C CD  . ARG   A 1 286 ? -33.240 -27.096 -8.666  1.00 55.41 ? 286 ARG   A CD  1 
ATOM   1964 N NE  . ARG   A 1 286 ? -31.840 -26.688 -8.637  1.00 55.63 ? 286 ARG   A NE  1 
ATOM   1965 C CZ  . ARG   A 1 286 ? -30.831 -27.478 -8.299  1.00 56.87 ? 286 ARG   A CZ  1 
ATOM   1966 N NH1 . ARG   A 1 286 ? -31.028 -28.738 -7.951  1.00 55.11 ? 286 ARG   A NH1 1 
ATOM   1967 N NH2 . ARG   A 1 286 ? -29.594 -26.991 -8.309  1.00 50.61 ? 286 ARG   A NH2 1 
ATOM   1968 N N   . ALA   A 1 287 ? -32.253 -27.889 -13.737 1.00 48.79 ? 287 ALA   A N   1 
ATOM   1969 C CA  . ALA   A 1 287 ? -31.822 -26.873 -14.690 1.00 50.13 ? 287 ALA   A CA  1 
ATOM   1970 C C   . ALA   A 1 287 ? -32.713 -26.863 -15.926 1.00 49.10 ? 287 ALA   A C   1 
ATOM   1971 O O   . ALA   A 1 287 ? -33.134 -25.798 -16.393 1.00 48.67 ? 287 ALA   A O   1 
ATOM   1972 C CB  . ALA   A 1 287 ? -30.367 -27.109 -15.084 1.00 50.64 ? 287 ALA   A CB  1 
ATOM   1973 N N   . ALA   A 1 288 ? -33.004 -28.047 -16.472 1.00 48.44 ? 288 ALA   A N   1 
ATOM   1974 C CA  . ALA   A 1 288 ? -33.866 -28.133 -17.646 1.00 50.71 ? 288 ALA   A CA  1 
ATOM   1975 C C   . ALA   A 1 288 ? -35.285 -27.687 -17.321 1.00 53.53 ? 288 ALA   A C   1 
ATOM   1976 O O   . ALA   A 1 288 ? -35.966 -27.101 -18.170 1.00 53.34 ? 288 ALA   A O   1 
ATOM   1977 C CB  . ALA   A 1 288 ? -33.863 -29.558 -18.196 1.00 47.11 ? 288 ALA   A CB  1 
ATOM   1978 N N   . ALA   A 1 289 ? -35.750 -27.958 -16.099 1.00 49.62 ? 289 ALA   A N   1 
ATOM   1979 C CA  . ALA   A 1 289 ? -37.093 -27.538 -15.712 1.00 49.69 ? 289 ALA   A CA  1 
ATOM   1980 C C   . ALA   A 1 289 ? -37.194 -26.020 -15.645 1.00 50.75 ? 289 ALA   A C   1 
ATOM   1981 O O   . ALA   A 1 289 ? -38.218 -25.439 -16.023 1.00 53.55 ? 289 ALA   A O   1 
ATOM   1982 C CB  . ALA   A 1 289 ? -37.475 -28.163 -14.370 1.00 46.33 ? 289 ALA   A CB  1 
ATOM   1983 N N   . ALA   A 1 290 ? -36.136 -25.360 -15.167 1.00 49.87 ? 290 ALA   A N   1 
ATOM   1984 C CA  . ALA   A 1 290 ? -36.107 -23.902 -15.150 1.00 50.77 ? 290 ALA   A CA  1 
ATOM   1985 C C   . ALA   A 1 290 ? -36.136 -23.310 -16.552 1.00 52.71 ? 290 ALA   A C   1 
ATOM   1986 O O   . ALA   A 1 290 ? -36.528 -22.146 -16.711 1.00 54.23 ? 290 ALA   A O   1 
ATOM   1987 C CB  . ALA   A 1 290 ? -34.866 -23.401 -14.407 1.00 49.67 ? 290 ALA   A CB  1 
ATOM   1988 N N   . CYS   A 1 291 ? -35.722 -24.074 -17.570 1.00 52.25 ? 291 CYS   A N   1 
ATOM   1989 C CA  . CYS   A 1 291 ? -35.801 -23.571 -18.937 1.00 54.77 ? 291 CYS   A CA  1 
ATOM   1990 C C   . CYS   A 1 291 ? -37.185 -23.794 -19.540 1.00 54.51 ? 291 CYS   A C   1 
ATOM   1991 O O   . CYS   A 1 291 ? -37.676 -22.948 -20.293 1.00 55.43 ? 291 CYS   A O   1 
ATOM   1992 C CB  . CYS   A 1 291 ? -34.726 -24.226 -19.797 1.00 50.49 ? 291 CYS   A CB  1 
ATOM   1993 S SG  . CYS   A 1 291 ? -33.032 -23.890 -19.257 1.00 48.85 ? 291 CYS   A SG  1 
ATOM   1994 N N   . GLU   A 1 292 ? -37.828 -24.923 -19.222 1.00 54.91 ? 292 GLU   A N   1 
ATOM   1995 C CA  . GLU   A 1 292 ? -39.219 -25.123 -19.625 1.00 55.42 ? 292 GLU   A CA  1 
ATOM   1996 C C   . GLU   A 1 292 ? -40.108 -24.012 -19.084 1.00 55.07 ? 292 GLU   A C   1 
ATOM   1997 O O   . GLU   A 1 292 ? -40.992 -23.514 -19.790 1.00 53.29 ? 292 GLU   A O   1 
ATOM   1998 C CB  . GLU   A 1 292 ? -39.731 -26.484 -19.143 1.00 56.21 ? 292 GLU   A CB  1 
ATOM   1999 C CG  . GLU   A 1 292 ? -39.371 -27.661 -20.036 1.00 56.53 ? 292 GLU   A CG  1 
ATOM   2000 C CD  . GLU   A 1 292 ? -40.233 -28.876 -19.759 1.00 60.35 ? 292 GLU   A CD  1 
ATOM   2001 O OE1 . GLU   A 1 292 ? -41.401 -28.889 -20.198 1.00 61.78 ? 292 GLU   A OE1 1 
ATOM   2002 O OE2 . GLU   A 1 292 ? -39.747 -29.814 -19.097 1.00 62.64 ? 292 GLU   A OE2 1 
ATOM   2003 N N   . ALA   A 1 293 ? -39.891 -23.615 -17.829 1.00 53.97 ? 293 ALA   A N   1 
ATOM   2004 C CA  . ALA   A 1 293 ? -40.634 -22.506 -17.246 1.00 55.04 ? 293 ALA   A CA  1 
ATOM   2005 C C   . ALA   A 1 293 ? -40.319 -21.173 -17.912 1.00 57.53 ? 293 ALA   A C   1 
ATOM   2006 O O   . ALA   A 1 293 ? -41.063 -20.209 -17.705 1.00 57.06 ? 293 ALA   A O   1 
ATOM   2007 C CB  . ALA   A 1 293 ? -40.351 -22.417 -15.746 1.00 52.73 ? 293 ALA   A CB  1 
ATOM   2008 N N   . SER   A 1 294 ? -39.245 -21.095 -18.700 1.00 54.82 ? 294 SER   A N   1 
ATOM   2009 C CA  . SER   A 1 294 ? -38.880 -19.885 -19.426 1.00 53.93 ? 294 SER   A CA  1 
ATOM   2010 C C   . SER   A 1 294 ? -39.204 -19.980 -20.914 1.00 52.47 ? 294 SER   A C   1 
ATOM   2011 O O   . SER   A 1 294 ? -38.720 -19.161 -21.703 1.00 55.24 ? 294 SER   A O   1 
ATOM   2012 C CB  . SER   A 1 294 ? -37.394 -19.574 -19.230 1.00 57.00 ? 294 SER   A CB  1 
ATOM   2013 O OG  . SER   A 1 294 ? -37.089 -19.345 -17.863 1.00 59.03 ? 294 SER   A OG  1 
ATOM   2014 N N   . GLY   A 1 295 ? -40.007 -20.960 -21.314 1.00 53.10 ? 295 GLY   A N   1 
ATOM   2015 C CA  . GLY   A 1 295 ? -40.434 -21.090 -22.691 1.00 54.41 ? 295 GLY   A CA  1 
ATOM   2016 C C   . GLY   A 1 295 ? -39.667 -22.076 -23.541 1.00 54.78 ? 295 GLY   A C   1 
ATOM   2017 O O   . GLY   A 1 295 ? -39.957 -22.186 -24.737 1.00 55.73 ? 295 GLY   A O   1 
ATOM   2018 N N   . ALA   A 1 296 ? -38.704 -22.792 -22.972 1.00 53.94 ? 296 ALA   A N   1 
ATOM   2019 C CA  . ALA   A 1 296 ? -37.938 -23.755 -23.746 1.00 50.08 ? 296 ALA   A CA  1 
ATOM   2020 C C   . ALA   A 1 296 ? -38.668 -25.093 -23.822 1.00 51.66 ? 296 ALA   A C   1 
ATOM   2021 O O   . ALA   A 1 296 ? -39.575 -25.388 -23.038 1.00 54.78 ? 296 ALA   A O   1 
ATOM   2022 C CB  . ALA   A 1 296 ? -36.547 -23.953 -23.142 1.00 48.17 ? 296 ALA   A CB  1 
ATOM   2023 N N   . THR   A 1 297 ? -38.258 -25.905 -24.792 1.00 51.56 ? 297 THR   A N   1 
ATOM   2024 C CA  . THR   A 1 297 ? -38.756 -27.262 -24.955 1.00 52.38 ? 297 THR   A CA  1 
ATOM   2025 C C   . THR   A 1 297 ? -37.634 -28.241 -24.640 1.00 49.40 ? 297 THR   A C   1 
ATOM   2026 O O   . THR   A 1 297 ? -36.491 -28.047 -25.066 1.00 50.02 ? 297 THR   A O   1 
ATOM   2027 C CB  . THR   A 1 297 ? -39.272 -27.498 -26.376 1.00 50.01 ? 297 THR   A CB  1 
ATOM   2028 O OG1 . THR   A 1 297 ? -38.177 -27.845 -27.230 1.00 52.07 ? 297 THR   A OG1 1 
ATOM   2029 C CG2 . THR   A 1 297 ? -39.941 -26.246 -26.915 1.00 49.01 ? 297 THR   A CG2 1 
ATOM   2030 N N   . VAL   A 1 298 ? -37.966 -29.293 -23.896 1.00 47.72 ? 298 VAL   A N   1 
ATOM   2031 C CA  . VAL   A 1 298 ? -36.983 -30.246 -23.397 1.00 46.90 ? 298 VAL   A CA  1 
ATOM   2032 C C   . VAL   A 1 298 ? -37.396 -31.647 -23.822 1.00 48.08 ? 298 VAL   A C   1 
ATOM   2033 O O   . VAL   A 1 298 ? -38.468 -32.128 -23.434 1.00 50.76 ? 298 VAL   A O   1 
ATOM   2034 C CB  . VAL   A 1 298 ? -36.833 -30.172 -21.868 1.00 47.52 ? 298 VAL   A CB  1 
ATOM   2035 C CG1 . VAL   A 1 298 ? -35.943 -31.300 -21.367 1.00 47.86 ? 298 VAL   A CG1 1 
ATOM   2036 C CG2 . VAL   A 1 298 ? -36.269 -28.821 -21.457 1.00 46.70 ? 298 VAL   A CG2 1 
ATOM   2037 N N   . ALA   A 1 299 ? -36.553 -32.295 -24.618 1.00 47.84 ? 299 ALA   A N   1 
ATOM   2038 C CA  . ALA   A 1 299 ? -36.697 -33.710 -24.919 1.00 46.98 ? 299 ALA   A CA  1 
ATOM   2039 C C   . ALA   A 1 299 ? -35.802 -34.533 -23.998 1.00 49.44 ? 299 ALA   A C   1 
ATOM   2040 O O   . ALA   A 1 299 ? -34.811 -34.039 -23.456 1.00 49.72 ? 299 ALA   A O   1 
ATOM   2041 C CB  . ALA   A 1 299 ? -36.346 -33.993 -26.379 1.00 44.14 ? 299 ALA   A CB  1 
ATOM   2042 N N   . THR   A 1 300 ? -36.162 -35.806 -23.828 1.00 47.38 ? 300 THR   A N   1 
ATOM   2043 C CA  . THR   A 1 300 ? -35.383 -36.733 -23.018 1.00 48.58 ? 300 THR   A CA  1 
ATOM   2044 C C   . THR   A 1 300 ? -34.799 -37.881 -23.831 1.00 47.13 ? 300 THR   A C   1 
ATOM   2045 O O   . THR   A 1 300 ? -34.144 -38.760 -23.255 1.00 49.66 ? 300 THR   A O   1 
ATOM   2046 C CB  . THR   A 1 300 ? -36.236 -37.293 -21.869 1.00 49.54 ? 300 THR   A CB  1 
ATOM   2047 O OG1 . THR   A 1 300 ? -37.487 -37.768 -22.381 1.00 49.50 ? 300 THR   A OG1 1 
ATOM   2048 C CG2 . THR   A 1 300 ? -36.487 -36.218 -20.817 1.00 47.48 ? 300 THR   A CG2 1 
ATOM   2049 N N   . SER   A 1 301 ? -35.018 -37.898 -25.144 1.00 47.49 ? 301 SER   A N   1 
ATOM   2050 C CA  . SER   A 1 301 ? -34.441 -38.884 -26.043 1.00 49.65 ? 301 SER   A CA  1 
ATOM   2051 C C   . SER   A 1 301 ? -34.617 -38.372 -27.463 1.00 51.56 ? 301 SER   A C   1 
ATOM   2052 O O   . SER   A 1 301 ? -35.428 -37.465 -27.723 1.00 47.43 ? 301 SER   A O   1 
ATOM   2053 C CB  . SER   A 1 301 ? -35.087 -40.265 -25.885 1.00 50.76 ? 301 SER   A CB  1 
ATOM   2054 O OG  . SER   A 1 301 ? -36.437 -40.247 -26.319 1.00 54.55 ? 301 SER   A OG  1 
ATOM   2055 N N   . SER   A 1 302 ? -33.847 -38.983 -28.388 1.00 50.21 ? 302 SER   A N   1 
ATOM   2056 C CA  . SER   A 1 302 ? -33.911 -38.605 -29.788 1.00 50.99 ? 302 SER   A CA  1 
ATOM   2057 C C   . SER   A 1 302 ? -33.410 -39.767 -30.630 1.00 52.82 ? 302 SER   A C   1 
ATOM   2058 O O   . SER   A 1 302 ? -32.398 -40.382 -30.265 1.00 53.11 ? 302 SER   A O   1 
ATOM   2059 C CB  . SER   A 1 302 ? -33.072 -37.353 -30.061 1.00 51.68 ? 302 SER   A CB  1 
ATOM   2060 O OG  . SER   A 1 302 ? -32.892 -37.155 -31.449 1.00 53.68 ? 302 SER   A OG  1 
ATOM   2061 N N   . PRO   A 1 303 ? -34.073 -40.092 -31.744 1.00 53.35 ? 303 PRO   A N   1 
ATOM   2062 C CA  . PRO   A 1 303 ? -33.531 -41.122 -32.645 1.00 53.03 ? 303 PRO   A CA  1 
ATOM   2063 C C   . PRO   A 1 303 ? -32.216 -40.719 -33.280 1.00 51.67 ? 303 PRO   A C   1 
ATOM   2064 O O   . PRO   A 1 303 ? -31.556 -41.575 -33.877 1.00 51.02 ? 303 PRO   A O   1 
ATOM   2065 C CB  . PRO   A 1 303 ? -34.641 -41.286 -33.694 1.00 52.64 ? 303 PRO   A CB  1 
ATOM   2066 C CG  . PRO   A 1 303 ? -35.389 -39.995 -33.655 1.00 53.22 ? 303 PRO   A CG  1 
ATOM   2067 C CD  . PRO   A 1 303 ? -35.363 -39.567 -32.221 1.00 53.66 ? 303 PRO   A CD  1 
ATOM   2068 N N   . ASP   A 1 304 ? -31.803 -39.459 -33.144 1.00 52.65 ? 304 ASP   A N   1 
ATOM   2069 C CA  . ASP   A 1 304 ? -30.588 -38.962 -33.774 1.00 52.53 ? 304 ASP   A CA  1 
ATOM   2070 C C   . ASP   A 1 304 ? -29.410 -38.856 -32.816 1.00 49.59 ? 304 ASP   A C   1 
ATOM   2071 O O   . ASP   A 1 304 ? -28.338 -38.396 -33.225 1.00 49.15 ? 304 ASP   A O   1 
ATOM   2072 C CB  . ASP   A 1 304 ? -30.847 -37.601 -34.424 1.00 54.49 ? 304 ASP   A CB  1 
ATOM   2073 C CG  . ASP   A 1 304 ? -31.774 -37.695 -35.619 1.00 59.12 ? 304 ASP   A CG  1 
ATOM   2074 O OD1 . ASP   A 1 304 ? -31.678 -38.691 -36.365 1.00 61.59 ? 304 ASP   A OD1 1 
ATOM   2075 O OD2 . ASP   A 1 304 ? -32.597 -36.777 -35.812 1.00 59.16 ? 304 ASP   A OD2 1 
ATOM   2076 N N   . LEU   A 1 305 ? -29.573 -39.262 -31.568 1.00 48.37 ? 305 LEU   A N   1 
ATOM   2077 C CA  . LEU   A 1 305 ? -28.442 -39.282 -30.652 1.00 46.60 ? 305 LEU   A CA  1 
ATOM   2078 C C   . LEU   A 1 305 ? -27.484 -40.385 -31.077 1.00 47.04 ? 305 LEU   A C   1 
ATOM   2079 O O   . LEU   A 1 305 ? -27.899 -41.548 -31.172 1.00 45.56 ? 305 LEU   A O   1 
ATOM   2080 C CB  . LEU   A 1 305 ? -28.899 -39.505 -29.213 1.00 48.99 ? 305 LEU   A CB  1 
ATOM   2081 C CG  . LEU   A 1 305 ? -27.771 -39.447 -28.176 1.00 49.80 ? 305 LEU   A CG  1 
ATOM   2082 C CD1 . LEU   A 1 305 ? -27.279 -38.017 -27.978 1.00 43.85 ? 305 LEU   A CD1 1 
ATOM   2083 C CD2 . LEU   A 1 305 ? -28.197 -40.066 -26.852 1.00 48.72 ? 305 LEU   A CD2 1 
ATOM   2084 N N   . PRO   A 1 306 ? -26.220 -40.075 -31.358 1.00 45.29 ? 306 PRO   A N   1 
ATOM   2085 C CA  . PRO   A 1 306 ? -25.276 -41.123 -31.752 1.00 46.98 ? 306 PRO   A CA  1 
ATOM   2086 C C   . PRO   A 1 306 ? -25.092 -42.140 -30.637 1.00 49.13 ? 306 PRO   A C   1 
ATOM   2087 O O   . PRO   A 1 306 ? -25.384 -41.883 -29.467 1.00 47.15 ? 306 PRO   A O   1 
ATOM   2088 C CB  . PRO   A 1 306 ? -23.980 -40.351 -32.026 1.00 43.06 ? 306 PRO   A CB  1 
ATOM   2089 C CG  . PRO   A 1 306 ? -24.418 -38.935 -32.265 1.00 44.06 ? 306 PRO   A CG  1 
ATOM   2090 C CD  . PRO   A 1 306 ? -25.604 -38.738 -31.376 1.00 46.05 ? 306 PRO   A CD  1 
ATOM   2091 N N   . ASP   A 1 307 ? -24.617 -43.324 -31.021 1.00 49.55 ? 307 ASP   A N   1 
ATOM   2092 C CA  . ASP   A 1 307 ? -24.341 -44.368 -30.044 1.00 49.97 ? 307 ASP   A CA  1 
ATOM   2093 C C   . ASP   A 1 307 ? -23.254 -43.894 -29.091 1.00 49.50 ? 307 ASP   A C   1 
ATOM   2094 O O   . ASP   A 1 307 ? -22.070 -43.891 -29.441 1.00 49.98 ? 307 ASP   A O   1 
ATOM   2095 C CB  . ASP   A 1 307 ? -23.928 -45.671 -30.736 1.00 49.10 ? 307 ASP   A CB  1 
ATOM   2096 C CG  . ASP   A 1 307 ? -23.774 -46.832 -29.763 1.00 51.48 ? 307 ASP   A CG  1 
ATOM   2097 O OD1 . ASP   A 1 307 ? -24.123 -46.677 -28.573 1.00 53.31 ? 307 ASP   A OD1 1 
ATOM   2098 O OD2 . ASP   A 1 307 ? -23.302 -47.907 -30.192 1.00 54.92 ? 307 ASP   A OD2 1 
ATOM   2099 N N   . LEU   A 1 308 ? -23.653 -43.474 -27.889 1.00 48.04 ? 308 LEU   A N   1 
ATOM   2100 C CA  . LEU   A 1 308 ? -22.678 -43.018 -26.904 1.00 47.42 ? 308 LEU   A CA  1 
ATOM   2101 C C   . LEU   A 1 308 ? -21.767 -44.153 -26.454 1.00 47.37 ? 308 LEU   A C   1 
ATOM   2102 O O   . LEU   A 1 308 ? -20.610 -43.910 -26.092 1.00 45.57 ? 308 LEU   A O   1 
ATOM   2103 C CB  . LEU   A 1 308 ? -23.395 -42.397 -25.705 1.00 43.60 ? 308 LEU   A CB  1 
ATOM   2104 C CG  . LEU   A 1 308 ? -24.370 -41.261 -26.025 1.00 46.27 ? 308 LEU   A CG  1 
ATOM   2105 C CD1 . LEU   A 1 308 ? -24.918 -40.649 -24.746 1.00 44.22 ? 308 LEU   A CD1 1 
ATOM   2106 C CD2 . LEU   A 1 308 ? -23.703 -40.201 -26.893 1.00 44.21 ? 308 LEU   A CD2 1 
ATOM   2107 N N   . SER   A 1 309 ? -22.264 -45.391 -26.474 1.00 46.11 ? 309 SER   A N   1 
ATOM   2108 C CA  . SER   A 1 309 ? -21.427 -46.531 -26.119 1.00 47.08 ? 309 SER   A CA  1 
ATOM   2109 C C   . SER   A 1 309 ? -20.294 -46.709 -27.122 1.00 47.68 ? 309 SER   A C   1 
ATOM   2110 O O   . SER   A 1 309 ? -19.130 -46.872 -26.742 1.00 46.24 ? 309 SER   A O   1 
ATOM   2111 C CB  . SER   A 1 309 ? -22.276 -47.798 -26.035 1.00 47.59 ? 309 SER   A CB  1 
ATOM   2112 O OG  . SER   A 1 309 ? -21.475 -48.916 -25.699 1.00 55.26 ? 309 SER   A OG  1 
ATOM   2113 N N   . ALA   A 1 310 ? -20.621 -46.681 -28.416 1.00 49.59 ? 310 ALA   A N   1 
ATOM   2114 C CA  . ALA   A 1 310 ? -19.587 -46.772 -29.441 1.00 48.67 ? 310 ALA   A CA  1 
ATOM   2115 C C   . ALA   A 1 310 ? -18.729 -45.515 -29.487 1.00 46.57 ? 310 ALA   A C   1 
ATOM   2116 O O   . ALA   A 1 310 ? -17.572 -45.570 -29.916 1.00 47.43 ? 310 ALA   A O   1 
ATOM   2117 C CB  . ALA   A 1 310 ? -20.222 -47.028 -30.807 1.00 45.15 ? 310 ALA   A CB  1 
ATOM   2118 N N   . LEU   A 1 311 ? -19.278 -44.378 -29.055 1.00 45.41 ? 311 LEU   A N   1 
ATOM   2119 C CA  . LEU   A 1 311 ? -18.524 -43.129 -29.077 1.00 47.00 ? 311 LEU   A CA  1 
ATOM   2120 C C   . LEU   A 1 311 ? -17.344 -43.190 -28.115 1.00 46.22 ? 311 LEU   A C   1 
ATOM   2121 O O   . LEU   A 1 311 ? -16.202 -42.902 -28.494 1.00 47.52 ? 311 LEU   A O   1 
ATOM   2122 C CB  . LEU   A 1 311 ? -19.452 -41.960 -28.733 1.00 44.47 ? 311 LEU   A CB  1 
ATOM   2123 C CG  . LEU   A 1 311 ? -19.024 -40.521 -29.051 1.00 42.11 ? 311 LEU   A CG  1 
ATOM   2124 C CD1 . LEU   A 1 311 ? -20.234 -39.607 -29.018 1.00 42.94 ? 311 LEU   A CD1 1 
ATOM   2125 C CD2 . LEU   A 1 311 ? -17.964 -40.003 -28.082 1.00 38.72 ? 311 LEU   A CD2 1 
ATOM   2126 N N   . VAL   A 1 312 ? -17.604 -43.567 -26.861 1.00 41.68 ? 312 VAL   A N   1 
ATOM   2127 C CA  . VAL   A 1 312 ? -16.558 -43.558 -25.844 1.00 45.02 ? 312 VAL   A CA  1 
ATOM   2128 C C   . VAL   A 1 312 ? -15.492 -44.607 -26.144 1.00 44.15 ? 312 VAL   A C   1 
ATOM   2129 O O   . VAL   A 1 312 ? -14.320 -44.428 -25.790 1.00 46.12 ? 312 VAL   A O   1 
ATOM   2130 C CB  . VAL   A 1 312 ? -17.179 -43.752 -24.446 1.00 42.28 ? 312 VAL   A CB  1 
ATOM   2131 C CG1 . VAL   A 1 312 ? -17.820 -45.127 -24.320 1.00 41.46 ? 312 VAL   A CG1 1 
ATOM   2132 C CG2 . VAL   A 1 312 ? -16.137 -43.531 -23.357 1.00 39.79 ? 312 VAL   A CG2 1 
ATOM   2133 N N   . ALA   A 1 313 ? -15.867 -45.706 -26.804 1.00 43.95 ? 313 ALA   A N   1 
ATOM   2134 C CA  . ALA   A 1 313 ? -14.876 -46.716 -27.160 1.00 47.03 ? 313 ALA   A CA  1 
ATOM   2135 C C   . ALA   A 1 313 ? -13.930 -46.201 -28.237 1.00 46.71 ? 313 ALA   A C   1 
ATOM   2136 O O   . ALA   A 1 313 ? -12.710 -46.382 -28.138 1.00 45.02 ? 313 ALA   A O   1 
ATOM   2137 C CB  . ALA   A 1 313 ? -15.573 -47.997 -27.618 1.00 48.37 ? 313 ALA   A CB  1 
ATOM   2138 N N   . ASP   A 1 314 ? -14.473 -45.552 -29.270 1.00 48.29 ? 314 ASP   A N   1 
ATOM   2139 C CA  . ASP   A 1 314 ? -13.624 -44.972 -30.306 1.00 49.38 ? 314 ASP   A CA  1 
ATOM   2140 C C   . ASP   A 1 314 ? -12.806 -43.808 -29.761 1.00 48.44 ? 314 ASP   A C   1 
ATOM   2141 O O   . ASP   A 1 314 ? -11.634 -43.642 -30.120 1.00 46.75 ? 314 ASP   A O   1 
ATOM   2142 C CB  . ASP   A 1 314 ? -14.474 -44.521 -31.493 1.00 48.75 ? 314 ASP   A CB  1 
ATOM   2143 C CG  . ASP   A 1 314 ? -15.187 -45.674 -32.171 1.00 54.68 ? 314 ASP   A CG  1 
ATOM   2144 O OD1 . ASP   A 1 314 ? -15.106 -46.811 -31.660 1.00 56.49 ? 314 ASP   A OD1 1 
ATOM   2145 O OD2 . ASP   A 1 314 ? -15.828 -45.445 -33.218 1.00 52.16 ? 314 ASP   A OD2 1 
ATOM   2146 N N   . TYR   A 1 315 ? -13.406 -42.993 -28.889 1.00 43.75 ? 315 TYR   A N   1 
ATOM   2147 C CA  . TYR   A 1 315 ? -12.678 -41.869 -28.311 1.00 43.12 ? 315 TYR   A CA  1 
ATOM   2148 C C   . TYR   A 1 315 ? -11.545 -42.350 -27.416 1.00 45.31 ? 315 TYR   A C   1 
ATOM   2149 O O   . TYR   A 1 315 ? -10.446 -41.784 -27.439 1.00 46.90 ? 315 TYR   A O   1 
ATOM   2150 C CB  . TYR   A 1 315 ? -13.634 -40.966 -27.529 1.00 43.56 ? 315 TYR   A CB  1 
ATOM   2151 C CG  . TYR   A 1 315 ? -12.941 -40.061 -26.534 1.00 43.94 ? 315 TYR   A CG  1 
ATOM   2152 C CD1 . TYR   A 1 315 ? -12.058 -39.077 -26.955 1.00 42.54 ? 315 TYR   A CD1 1 
ATOM   2153 C CD2 . TYR   A 1 315 ? -13.179 -40.185 -25.171 1.00 45.00 ? 315 TYR   A CD2 1 
ATOM   2154 C CE1 . TYR   A 1 315 ? -11.425 -38.250 -26.049 1.00 43.01 ? 315 TYR   A CE1 1 
ATOM   2155 C CE2 . TYR   A 1 315 ? -12.553 -39.359 -24.256 1.00 45.38 ? 315 TYR   A CE2 1 
ATOM   2156 C CZ  . TYR   A 1 315 ? -11.675 -38.395 -24.699 1.00 43.87 ? 315 TYR   A CZ  1 
ATOM   2157 O OH  . TYR   A 1 315 ? -11.049 -37.570 -23.789 1.00 46.11 ? 315 TYR   A OH  1 
ATOM   2158 N N   . THR   A 1 316 ? -11.794 -43.394 -26.621 1.00 45.89 ? 316 THR   A N   1 
ATOM   2159 C CA  . THR   A 1 316 ? -10.768 -43.890 -25.711 1.00 43.69 ? 316 THR   A CA  1 
ATOM   2160 C C   . THR   A 1 316 ? -9.557  -44.409 -26.476 1.00 46.80 ? 316 THR   A C   1 
ATOM   2161 O O   . THR   A 1 316 ? -8.411  -44.135 -26.099 1.00 47.56 ? 316 THR   A O   1 
ATOM   2162 C CB  . THR   A 1 316 ? -11.347 -44.985 -24.813 1.00 42.86 ? 316 THR   A CB  1 
ATOM   2163 O OG1 . THR   A 1 316 ? -12.359 -44.426 -23.964 1.00 44.64 ? 316 THR   A OG1 1 
ATOM   2164 C CG2 . THR   A 1 316 ? -10.259 -45.609 -23.954 1.00 43.75 ? 316 THR   A CG2 1 
ATOM   2165 N N   . ARG   A 1 317 ? -9.789  -45.140 -27.569 1.00 44.94 ? 317 ARG   A N   1 
ATOM   2166 C CA  . ARG   A 1 317 ? -8.676  -45.708 -28.319 1.00 45.66 ? 317 ARG   A CA  1 
ATOM   2167 C C   . ARG   A 1 317 ? -7.941  -44.652 -29.134 1.00 46.54 ? 317 ARG   A C   1 
ATOM   2168 O O   . ARG   A 1 317 ? -6.740  -44.800 -29.382 1.00 47.93 ? 317 ARG   A O   1 
ATOM   2169 C CB  . ARG   A 1 317 ? -9.167  -46.844 -29.222 1.00 48.08 ? 317 ARG   A CB  1 
ATOM   2170 C CG  . ARG   A 1 317 ? -9.854  -46.407 -30.509 1.00 52.77 ? 317 ARG   A CG  1 
ATOM   2171 C CD  . ARG   A 1 317 ? -10.186 -47.610 -31.378 1.00 59.02 ? 317 ARG   A CD  1 
ATOM   2172 N NE  . ARG   A 1 317 ? -11.537 -48.115 -31.156 1.00 63.24 ? 317 ARG   A NE  1 
ATOM   2173 C CZ  . ARG   A 1 317 ? -11.861 -49.052 -30.275 1.00 62.86 ? 317 ARG   A CZ  1 
ATOM   2174 N NH1 . ARG   A 1 317 ? -10.954 -49.607 -29.489 1.00 60.53 ? 317 ARG   A NH1 1 
ATOM   2175 N NH2 . ARG   A 1 317 ? -13.130 -49.438 -30.177 1.00 60.32 ? 317 ARG   A NH2 1 
ATOM   2176 N N   . MET   A 1 318 ? -8.622  -43.582 -29.552 1.00 45.94 ? 318 MET   A N   1 
ATOM   2177 C CA  . MET   A 1 318 ? -7.899  -42.474 -30.168 1.00 44.68 ? 318 MET   A CA  1 
ATOM   2178 C C   . MET   A 1 318 ? -7.134  -41.678 -29.119 1.00 45.50 ? 318 MET   A C   1 
ATOM   2179 O O   . MET   A 1 318 ? -6.017  -41.215 -29.375 1.00 44.06 ? 318 MET   A O   1 
ATOM   2180 C CB  . MET   A 1 318 ? -8.860  -41.568 -30.939 1.00 44.32 ? 318 MET   A CB  1 
ATOM   2181 C CG  . MET   A 1 318 ? -8.194  -40.327 -31.520 1.00 44.41 ? 318 MET   A CG  1 
ATOM   2182 S SD  . MET   A 1 318 ? -9.327  -39.288 -32.462 1.00 48.97 ? 318 MET   A SD  1 
ATOM   2183 C CE  . MET   A 1 318 ? -9.664  -40.354 -33.859 1.00 43.73 ? 318 MET   A CE  1 
ATOM   2184 N N   . LEU   A 1 319 ? -7.717  -41.527 -27.929 1.00 43.89 ? 319 LEU   A N   1 
ATOM   2185 C CA  . LEU   A 1 319 ? -7.062  -40.786 -26.856 1.00 45.40 ? 319 LEU   A CA  1 
ATOM   2186 C C   . LEU   A 1 319 ? -5.751  -41.449 -26.449 1.00 46.33 ? 319 LEU   A C   1 
ATOM   2187 O O   . LEU   A 1 319 ? -4.712  -40.787 -26.346 1.00 46.85 ? 319 LEU   A O   1 
ATOM   2188 C CB  . LEU   A 1 319 ? -8.006  -40.673 -25.660 1.00 43.70 ? 319 LEU   A CB  1 
ATOM   2189 C CG  . LEU   A 1 319 ? -7.491  -39.980 -24.397 1.00 46.57 ? 319 LEU   A CG  1 
ATOM   2190 C CD1 . LEU   A 1 319 ? -7.215  -38.508 -24.662 1.00 47.48 ? 319 LEU   A CD1 1 
ATOM   2191 C CD2 . LEU   A 1 319 ? -8.485  -40.148 -23.260 1.00 49.84 ? 319 LEU   A CD2 1 
ATOM   2192 N N   . LEU   A 1 320 ? -5.781  -42.764 -26.218 1.00 45.12 ? 320 LEU   A N   1 
ATOM   2193 C CA  . LEU   A 1 320 ? -4.571  -43.481 -25.822 1.00 46.47 ? 320 LEU   A CA  1 
ATOM   2194 C C   . LEU   A 1 320 ? -3.501  -43.420 -26.904 1.00 47.39 ? 320 LEU   A C   1 
ATOM   2195 O O   . LEU   A 1 320 ? -2.306  -43.374 -26.593 1.00 45.73 ? 320 LEU   A O   1 
ATOM   2196 C CB  . LEU   A 1 320 ? -4.909  -44.936 -25.493 1.00 44.74 ? 320 LEU   A CB  1 
ATOM   2197 C CG  . LEU   A 1 320 ? -5.840  -45.170 -24.303 1.00 47.56 ? 320 LEU   A CG  1 
ATOM   2198 C CD1 . LEU   A 1 320 ? -6.269  -46.626 -24.240 1.00 46.97 ? 320 LEU   A CD1 1 
ATOM   2199 C CD2 . LEU   A 1 320 ? -5.166  -44.744 -23.010 1.00 42.92 ? 320 LEU   A CD2 1 
ATOM   2200 N N   . VAL   A 1 321 ? -3.909  -43.421 -28.175 1.00 47.93 ? 321 VAL   A N   1 
ATOM   2201 C CA  . VAL   A 1 321 ? -2.947  -43.322 -29.268 1.00 46.09 ? 321 VAL   A CA  1 
ATOM   2202 C C   . VAL   A 1 321 ? -2.308  -41.940 -29.291 1.00 46.32 ? 321 VAL   A C   1 
ATOM   2203 O O   . VAL   A 1 321 ? -1.089  -41.804 -29.451 1.00 44.60 ? 321 VAL   A O   1 
ATOM   2204 C CB  . VAL   A 1 321 ? -3.627  -43.655 -30.609 1.00 47.29 ? 321 VAL   A CB  1 
ATOM   2205 C CG1 . VAL   A 1 321 ? -2.793  -43.138 -31.766 1.00 42.81 ? 321 VAL   A CG1 1 
ATOM   2206 C CG2 . VAL   A 1 321 ? -3.843  -45.153 -30.736 1.00 48.67 ? 321 VAL   A CG2 1 
ATOM   2207 N N   . VAL   A 1 322 ? -3.121  -40.893 -29.133 1.00 44.76 ? 322 VAL   A N   1 
ATOM   2208 C CA  . VAL   A 1 322 ? -2.595  -39.532 -29.166 1.00 47.14 ? 322 VAL   A CA  1 
ATOM   2209 C C   . VAL   A 1 322 ? -1.645  -39.296 -27.999 1.00 47.85 ? 322 VAL   A C   1 
ATOM   2210 O O   . VAL   A 1 322 ? -0.574  -38.699 -28.161 1.00 47.38 ? 322 VAL   A O   1 
ATOM   2211 C CB  . VAL   A 1 322 ? -3.750  -38.513 -29.174 1.00 46.39 ? 322 VAL   A CB  1 
ATOM   2212 C CG1 . VAL   A 1 322 ? -3.215  -37.104 -28.983 1.00 48.77 ? 322 VAL   A CG1 1 
ATOM   2213 C CG2 . VAL   A 1 322 ? -4.532  -38.607 -30.479 1.00 45.37 ? 322 VAL   A CG2 1 
ATOM   2214 N N   . LEU   A 1 323 ? -2.017  -39.768 -26.806 1.00 47.01 ? 323 LEU   A N   1 
ATOM   2215 C CA  . LEU   A 1 323 ? -1.184  -39.545 -25.628 1.00 49.72 ? 323 LEU   A CA  1 
ATOM   2216 C C   . LEU   A 1 323 ? 0.137   -40.300 -25.726 1.00 48.59 ? 323 LEU   A C   1 
ATOM   2217 O O   . LEU   A 1 323 ? 1.175   -39.803 -25.274 1.00 46.59 ? 323 LEU   A O   1 
ATOM   2218 C CB  . LEU   A 1 323 ? -1.945  -39.950 -24.365 1.00 50.22 ? 323 LEU   A CB  1 
ATOM   2219 C CG  . LEU   A 1 323 ? -3.188  -39.119 -24.046 1.00 50.14 ? 323 LEU   A CG  1 
ATOM   2220 C CD1 . LEU   A 1 323 ? -3.852  -39.601 -22.766 1.00 54.04 ? 323 LEU   A CD1 1 
ATOM   2221 C CD2 . LEU   A 1 323 ? -2.833  -37.643 -23.949 1.00 48.62 ? 323 LEU   A CD2 1 
ATOM   2222 N N   . ALA   A 1 324 ? 0.122   -41.498 -26.305 1.00 46.86 ? 324 ALA   A N   1 
ATOM   2223 C CA  . ALA   A 1 324 ? 1.338   -42.276 -26.503 1.00 48.84 ? 324 ALA   A CA  1 
ATOM   2224 C C   . ALA   A 1 324 ? 2.080   -41.897 -27.780 1.00 47.33 ? 324 ALA   A C   1 
ATOM   2225 O O   . ALA   A 1 324 ? 3.125   -42.489 -28.070 1.00 46.33 ? 324 ALA   A O   1 
ATOM   2226 C CB  . ALA   A 1 324 ? 1.011   -43.774 -26.518 1.00 47.19 ? 324 ALA   A CB  1 
ATOM   2227 N N   . ARG   A 1 325 ? 1.566   -40.927 -28.540 1.00 44.58 ? 325 ARG   A N   1 
ATOM   2228 C CA  . ARG   A 1 325 ? 2.192   -40.462 -29.781 1.00 48.08 ? 325 ARG   A CA  1 
ATOM   2229 C C   . ARG   A 1 325 ? 2.449   -41.617 -30.748 1.00 48.77 ? 325 ARG   A C   1 
ATOM   2230 O O   . ARG   A 1 325 ? 3.485   -41.682 -31.411 1.00 46.55 ? 325 ARG   A O   1 
ATOM   2231 C CB  . ARG   A 1 325 ? 3.485   -39.694 -29.496 1.00 49.83 ? 325 ARG   A CB  1 
ATOM   2232 C CG  . ARG   A 1 325 ? 3.271   -38.309 -28.917 1.00 50.97 ? 325 ARG   A CG  1 
ATOM   2233 C CD  . ARG   A 1 325 ? 4.570   -37.527 -28.891 1.00 53.60 ? 325 ARG   A CD  1 
ATOM   2234 N NE  . ARG   A 1 325 ? 5.050   -37.200 -30.228 1.00 53.13 ? 325 ARG   A NE  1 
ATOM   2235 C CZ  . ARG   A 1 325 ? 4.838   -36.041 -30.836 1.00 50.40 ? 325 ARG   A CZ  1 
ATOM   2236 N NH1 . ARG   A 1 325 ? 4.174   -35.063 -30.243 1.00 52.58 ? 325 ARG   A NH1 1 
ATOM   2237 N NH2 . ARG   A 1 325 ? 5.305   -35.859 -32.067 1.00 48.92 ? 325 ARG   A NH2 1 
ATOM   2238 N N   . GLY   A 1 326 ? 1.488   -42.534 -30.836 1.00 46.40 ? 326 GLY   A N   1 
ATOM   2239 C CA  . GLY   A 1 326 ? 1.610   -43.644 -31.760 1.00 45.81 ? 326 GLY   A CA  1 
ATOM   2240 C C   . GLY   A 1 326 ? 2.593   -44.721 -31.362 1.00 48.39 ? 326 GLY   A C   1 
ATOM   2241 O O   . GLY   A 1 326 ? 2.836   -45.637 -32.152 1.00 50.70 ? 326 GLY   A O   1 
ATOM   2242 N N   . LEU   A 1 327 ? 3.173   -44.639 -30.170 1.00 49.52 ? 327 LEU   A N   1 
ATOM   2243 C CA  . LEU   A 1 327 ? 4.096   -45.652 -29.682 1.00 51.16 ? 327 LEU   A CA  1 
ATOM   2244 C C   . LEU   A 1 327 ? 3.332   -46.758 -28.965 1.00 52.85 ? 327 LEU   A C   1 
ATOM   2245 O O   . LEU   A 1 327 ? 2.274   -46.530 -28.375 1.00 56.05 ? 327 LEU   A O   1 
ATOM   2246 C CB  . LEU   A 1 327 ? 5.134   -45.037 -28.740 1.00 46.81 ? 327 LEU   A CB  1 
ATOM   2247 C CG  . LEU   A 1 327 ? 6.058   -43.975 -29.342 1.00 45.03 ? 327 LEU   A CG  1 
ATOM   2248 C CD1 . LEU   A 1 327 ? 6.981   -43.399 -28.278 1.00 45.69 ? 327 LEU   A CD1 1 
ATOM   2249 C CD2 . LEU   A 1 327 ? 6.864   -44.562 -30.485 1.00 47.38 ? 327 LEU   A CD2 1 
ATOM   2250 N N   . ALA   A 1 328 ? 3.878   -47.964 -29.031 1.00 53.61 ? 328 ALA   A N   1 
ATOM   2251 C CA  . ALA   A 1 328 ? 3.289   -49.154 -28.445 1.00 61.77 ? 328 ALA   A CA  1 
ATOM   2252 C C   . ALA   A 1 328 ? 4.259   -49.779 -27.453 1.00 65.97 ? 328 ALA   A C   1 
ATOM   2253 O O   . ALA   A 1 328 ? 5.470   -49.541 -27.528 1.00 64.53 ? 328 ALA   A O   1 
ATOM   2254 C CB  . ALA   A 1 328 ? 2.926   -50.173 -29.536 1.00 60.01 ? 328 ALA   A CB  1 
ATOM   2255 N N   . PRO   A 1 329 ? 3.761   -50.586 -26.502 1.00 69.14 ? 329 PRO   A N   1 
ATOM   2256 C CA  . PRO   A 1 329 ? 4.664   -51.252 -25.550 1.00 71.08 ? 329 PRO   A CA  1 
ATOM   2257 C C   . PRO   A 1 329 ? 5.649   -52.205 -26.210 1.00 75.57 ? 329 PRO   A C   1 
ATOM   2258 O O   . PRO   A 1 329 ? 5.634   -52.388 -27.431 1.00 76.81 ? 329 PRO   A O   1 
ATOM   2259 C CB  . PRO   A 1 329 ? 3.699   -52.003 -24.624 1.00 71.04 ? 329 PRO   A CB  1 
ATOM   2260 C CG  . PRO   A 1 329 ? 2.421   -51.237 -24.714 1.00 70.42 ? 329 PRO   A CG  1 
ATOM   2261 C CD  . PRO   A 1 329 ? 2.345   -50.771 -26.140 1.00 71.27 ? 329 PRO   A CD  1 
ATOM   2262 N N   . GLU   A 1 330 ? 6.509   -52.821 -25.405 1.00 76.19 ? 330 GLU   A N   1 
ATOM   2263 C CA  . GLU   A 1 330 ? 7.514   -53.728 -25.940 1.00 80.34 ? 330 GLU   A CA  1 
ATOM   2264 C C   . GLU   A 1 330 ? 6.850   -54.954 -26.559 1.00 81.62 ? 330 GLU   A C   1 
ATOM   2265 O O   . GLU   A 1 330 ? 6.036   -55.626 -25.919 1.00 80.31 ? 330 GLU   A O   1 
ATOM   2266 C CB  . GLU   A 1 330 ? 8.483   -54.150 -24.838 1.00 84.38 ? 330 GLU   A CB  1 
ATOM   2267 C CG  . GLU   A 1 330 ? 9.636   -55.007 -25.329 1.00 85.13 ? 330 GLU   A CG  1 
ATOM   2268 C CD  . GLU   A 1 330 ? 10.502  -54.281 -26.335 1.00 88.66 ? 330 GLU   A CD  1 
ATOM   2269 O OE1 . GLU   A 1 330 ? 11.018  -53.198 -25.997 1.00 90.55 ? 330 GLU   A OE1 1 
ATOM   2270 O OE2 . GLU   A 1 330 ? 10.660  -54.785 -27.466 1.00 87.17 ? 330 GLU   A OE2 1 
ATOM   2271 N N   . GLY   A 1 331 ? 7.202   -55.249 -27.810 1.00 80.30 ? 331 GLY   A N   1 
ATOM   2272 C CA  . GLY   A 1 331 ? 6.644   -56.380 -28.518 1.00 80.63 ? 331 GLY   A CA  1 
ATOM   2273 C C   . GLY   A 1 331 ? 5.258   -56.159 -29.065 1.00 82.12 ? 331 GLY   A C   1 
ATOM   2274 O O   . GLY   A 1 331 ? 4.867   -56.838 -30.026 1.00 84.70 ? 331 GLY   A O   1 
ATOM   2275 N N   . THR   A 1 332 ? 4.503   -55.230 -28.486 1.00 79.12 ? 332 THR   A N   1 
ATOM   2276 C CA  . THR   A 1 332 ? 3.198   -54.886 -29.021 1.00 76.42 ? 332 THR   A CA  1 
ATOM   2277 C C   . THR   A 1 332 ? 3.354   -54.146 -30.343 1.00 75.04 ? 332 THR   A C   1 
ATOM   2278 O O   . THR   A 1 332 ? 4.224   -53.284 -30.496 1.00 73.53 ? 332 THR   A O   1 
ATOM   2279 C CB  . THR   A 1 332 ? 2.412   -54.033 -28.023 1.00 76.09 ? 332 THR   A CB  1 
ATOM   2280 O OG1 . THR   A 1 332 ? 2.364   -54.702 -26.756 1.00 79.49 ? 332 THR   A OG1 1 
ATOM   2281 C CG2 . THR   A 1 332 ? 0.987   -53.795 -28.524 1.00 75.16 ? 332 THR   A CG2 1 
ATOM   2282 N N   . GLU   A 1 333 ? 2.515   -54.503 -31.308 1.00 74.00 ? 333 GLU   A N   1 
ATOM   2283 C CA  . GLU   A 1 333 ? 2.536   -53.845 -32.602 1.00 72.13 ? 333 GLU   A CA  1 
ATOM   2284 C C   . GLU   A 1 333 ? 1.793   -52.514 -32.525 1.00 65.49 ? 333 GLU   A C   1 
ATOM   2285 O O   . GLU   A 1 333 ? 0.704   -52.437 -31.943 1.00 64.56 ? 333 GLU   A O   1 
ATOM   2286 C CB  . GLU   A 1 333 ? 1.891   -54.731 -33.665 1.00 69.98 ? 333 GLU   A CB  1 
ATOM   2287 C CG  . GLU   A 1 333 ? 2.741   -55.931 -34.073 1.00 78.02 ? 333 GLU   A CG  1 
ATOM   2288 C CD  . GLU   A 1 333 ? 2.828   -56.990 -32.989 1.00 87.02 ? 333 GLU   A CD  1 
ATOM   2289 O OE1 . GLU   A 1 333 ? 1.977   -56.988 -32.076 1.00 84.14 ? 333 GLU   A OE1 1 
ATOM   2290 O OE2 . GLU   A 1 333 ? 3.745   -57.832 -33.047 1.00 87.26 ? 333 GLU   A OE2 1 
ATOM   2291 N N   . PRO   A 1 334 ? 2.357   -51.459 -33.094 1.00 59.81 ? 334 PRO   A N   1 
ATOM   2292 C CA  . PRO   A 1 334 ? 1.730   -50.141 -33.005 1.00 55.99 ? 334 PRO   A CA  1 
ATOM   2293 C C   . PRO   A 1 334 ? 0.623   -49.985 -34.039 1.00 51.45 ? 334 PRO   A C   1 
ATOM   2294 O O   . PRO   A 1 334 ? 0.490   -50.766 -34.982 1.00 50.97 ? 334 PRO   A O   1 
ATOM   2295 C CB  . PRO   A 1 334 ? 2.889   -49.169 -33.283 1.00 55.23 ? 334 PRO   A CB  1 
ATOM   2296 C CG  . PRO   A 1 334 ? 4.092   -50.034 -33.648 1.00 57.18 ? 334 PRO   A CG  1 
ATOM   2297 C CD  . PRO   A 1 334 ? 3.587   -51.419 -33.895 1.00 57.35 ? 334 PRO   A CD  1 
ATOM   2298 N N   . VAL   A 1 335 ? -0.189  -48.948 -33.835 1.00 48.75 ? 335 VAL   A N   1 
ATOM   2299 C CA  . VAL   A 1 335 ? -1.189  -48.583 -34.827 1.00 45.99 ? 335 VAL   A CA  1 
ATOM   2300 C C   . VAL   A 1 335 ? -0.485  -48.027 -36.055 1.00 45.23 ? 335 VAL   A C   1 
ATOM   2301 O O   . VAL   A 1 335 ? 0.338   -47.107 -35.955 1.00 47.77 ? 335 VAL   A O   1 
ATOM   2302 C CB  . VAL   A 1 335 ? -2.183  -47.567 -34.247 1.00 44.25 ? 335 VAL   A CB  1 
ATOM   2303 C CG1 . VAL   A 1 335 ? -3.225  -47.196 -35.293 1.00 43.39 ? 335 VAL   A CG1 1 
ATOM   2304 C CG2 . VAL   A 1 335 ? -2.847  -48.124 -32.996 1.00 41.73 ? 335 VAL   A CG2 1 
ATOM   2305 N N   . SER   A 1 336 ? -0.796  -48.589 -37.219 1.00 43.54 ? 336 SER   A N   1 
ATOM   2306 C CA  . SER   A 1 336 ? -0.205  -48.099 -38.452 1.00 46.61 ? 336 SER   A CA  1 
ATOM   2307 C C   . SER   A 1 336 ? -0.769  -46.725 -38.800 1.00 46.72 ? 336 SER   A C   1 
ATOM   2308 O O   . SER   A 1 336 ? -1.846  -46.330 -38.348 1.00 46.50 ? 336 SER   A O   1 
ATOM   2309 C CB  . SER   A 1 336 ? -0.461  -49.075 -39.599 1.00 46.67 ? 336 SER   A CB  1 
ATOM   2310 O OG  . SER   A 1 336 ? -1.835  -49.096 -39.949 1.00 48.75 ? 336 SER   A OG  1 
ATOM   2311 N N   . LEU   A 1 337 ? -0.015  -45.989 -39.618 1.00 43.81 ? 337 LEU   A N   1 
ATOM   2312 C CA  . LEU   A 1 337 ? -0.483  -44.682 -40.065 1.00 42.54 ? 337 LEU   A CA  1 
ATOM   2313 C C   . LEU   A 1 337 ? -1.747  -44.801 -40.907 1.00 46.02 ? 337 LEU   A C   1 
ATOM   2314 O O   . LEU   A 1 337 ? -2.601  -43.909 -40.873 1.00 45.88 ? 337 LEU   A O   1 
ATOM   2315 C CB  . LEU   A 1 337 ? 0.623   -43.971 -40.844 1.00 43.42 ? 337 LEU   A CB  1 
ATOM   2316 C CG  . LEU   A 1 337 ? 0.292   -42.592 -41.408 1.00 44.03 ? 337 LEU   A CG  1 
ATOM   2317 C CD1 . LEU   A 1 337 ? -0.280  -41.682 -40.335 1.00 44.07 ? 337 LEU   A CD1 1 
ATOM   2318 C CD2 . LEU   A 1 337 ? 1.537   -41.981 -42.014 1.00 41.51 ? 337 LEU   A CD2 1 
ATOM   2319 N N   . ASN   A 1 338 ? -1.892  -45.898 -41.654 1.00 46.63 ? 338 ASN   A N   1 
ATOM   2320 C CA  . ASN   A 1 338 ? -3.107  -46.099 -42.438 1.00 45.39 ? 338 ASN   A CA  1 
ATOM   2321 C C   . ASN   A 1 338 ? -4.316  -46.306 -41.534 1.00 45.39 ? 338 ASN   A C   1 
ATOM   2322 O O   . ASN   A 1 338 ? -5.389  -45.744 -41.784 1.00 46.42 ? 338 ASN   A O   1 
ATOM   2323 C CB  . ASN   A 1 338 ? -2.933  -47.285 -43.388 1.00 47.24 ? 338 ASN   A CB  1 
ATOM   2324 C CG  . ASN   A 1 338 ? -4.168  -47.543 -44.230 1.00 47.67 ? 338 ASN   A CG  1 
ATOM   2325 O OD1 . ASN   A 1 338 ? -4.392  -46.878 -45.240 1.00 48.87 ? 338 ASN   A OD1 1 
ATOM   2326 N ND2 . ASN   A 1 338 ? -4.979  -48.508 -43.815 1.00 46.77 ? 338 ASN   A ND2 1 
ATOM   2327 N N   . ALA   A 1 339 ? -4.163  -47.105 -40.476 1.00 43.36 ? 339 ALA   A N   1 
ATOM   2328 C CA  . ALA   A 1 339 ? -5.248  -47.266 -39.516 1.00 43.16 ? 339 ALA   A CA  1 
ATOM   2329 C C   . ALA   A 1 339 ? -5.570  -45.953 -38.816 1.00 44.83 ? 339 ALA   A C   1 
ATOM   2330 O O   . ALA   A 1 339 ? -6.720  -45.722 -38.428 1.00 44.94 ? 339 ALA   A O   1 
ATOM   2331 C CB  . ALA   A 1 339 ? -4.890  -48.342 -38.492 1.00 42.82 ? 339 ALA   A CB  1 
ATOM   2332 N N   . TRP   A 1 340 ? -4.570  -45.084 -38.648 1.00 44.18 ? 340 TRP   A N   1 
ATOM   2333 C CA  . TRP   A 1 340 ? -4.805  -43.782 -38.032 1.00 42.75 ? 340 TRP   A CA  1 
ATOM   2334 C C   . TRP   A 1 340 ? -5.696  -42.915 -38.912 1.00 44.46 ? 340 TRP   A C   1 
ATOM   2335 O O   . TRP   A 1 340 ? -6.627  -42.265 -38.425 1.00 42.73 ? 340 TRP   A O   1 
ATOM   2336 C CB  . TRP   A 1 340 ? -3.470  -43.086 -37.762 1.00 42.62 ? 340 TRP   A CB  1 
ATOM   2337 C CG  . TRP   A 1 340 ? -3.604  -41.650 -37.359 1.00 43.73 ? 340 TRP   A CG  1 
ATOM   2338 C CD1 . TRP   A 1 340 ? -3.242  -40.556 -38.089 1.00 43.42 ? 340 TRP   A CD1 1 
ATOM   2339 C CD2 . TRP   A 1 340 ? -4.141  -41.151 -36.129 1.00 43.23 ? 340 TRP   A CD2 1 
ATOM   2340 N NE1 . TRP   A 1 340 ? -3.516  -39.407 -37.388 1.00 43.82 ? 340 TRP   A NE1 1 
ATOM   2341 C CE2 . TRP   A 1 340 ? -4.072  -39.745 -36.182 1.00 45.44 ? 340 TRP   A CE2 1 
ATOM   2342 C CE3 . TRP   A 1 340 ? -4.677  -41.758 -34.987 1.00 45.21 ? 340 TRP   A CE3 1 
ATOM   2343 C CZ2 . TRP   A 1 340 ? -4.517  -38.937 -35.139 1.00 45.17 ? 340 TRP   A CZ2 1 
ATOM   2344 C CZ3 . TRP   A 1 340 ? -5.116  -40.955 -33.952 1.00 46.54 ? 340 TRP   A CZ3 1 
ATOM   2345 C CH2 . TRP   A 1 340 ? -5.034  -39.560 -34.034 1.00 44.66 ? 340 TRP   A CH2 1 
ATOM   2346 N N   . TYR   A 1 341 ? -5.419  -42.890 -40.218 1.00 43.83 ? 341 TYR   A N   1 
ATOM   2347 C CA  . TYR   A 1 341 ? -6.261  -42.143 -41.146 1.00 44.03 ? 341 TYR   A CA  1 
ATOM   2348 C C   . TYR   A 1 341 ? -7.689  -42.671 -41.137 1.00 44.33 ? 341 TYR   A C   1 
ATOM   2349 O O   . TYR   A 1 341 ? -8.644  -41.899 -41.268 1.00 41.67 ? 341 TYR   A O   1 
ATOM   2350 C CB  . TYR   A 1 341 ? -5.671  -42.207 -42.557 1.00 42.83 ? 341 TYR   A CB  1 
ATOM   2351 C CG  . TYR   A 1 341 ? -4.394  -41.416 -42.731 1.00 42.04 ? 341 TYR   A CG  1 
ATOM   2352 C CD1 . TYR   A 1 341 ? -4.174  -40.248 -42.011 1.00 42.85 ? 341 TYR   A CD1 1 
ATOM   2353 C CD2 . TYR   A 1 341 ? -3.408  -41.838 -43.613 1.00 44.36 ? 341 TYR   A CD2 1 
ATOM   2354 C CE1 . TYR   A 1 341 ? -3.010  -39.522 -42.167 1.00 41.65 ? 341 TYR   A CE1 1 
ATOM   2355 C CE2 . TYR   A 1 341 ? -2.239  -41.116 -43.776 1.00 43.95 ? 341 TYR   A CE2 1 
ATOM   2356 C CZ  . TYR   A 1 341 ? -2.047  -39.960 -43.050 1.00 43.09 ? 341 TYR   A CZ  1 
ATOM   2357 O OH  . TYR   A 1 341 ? -0.886  -39.239 -43.205 1.00 43.25 ? 341 TYR   A OH  1 
ATOM   2358 N N   . ALA   A 1 342 ? -7.853  -43.986 -40.987 1.00 44.40 ? 342 ALA   A N   1 
ATOM   2359 C CA  . ALA   A 1 342 ? -9.189  -44.560 -40.879 1.00 41.61 ? 342 ALA   A CA  1 
ATOM   2360 C C   . ALA   A 1 342 ? -9.866  -44.146 -39.580 1.00 42.16 ? 342 ALA   A C   1 
ATOM   2361 O O   . ALA   A 1 342 ? -11.093 -43.998 -39.539 1.00 44.39 ? 342 ALA   A O   1 
ATOM   2362 C CB  . ALA   A 1 342 ? -9.115  -46.086 -40.976 1.00 40.22 ? 342 ALA   A CB  1 
ATOM   2363 N N   . MET   A 1 343 ? -9.084  -43.947 -38.517 1.00 41.46 ? 343 MET   A N   1 
ATOM   2364 C CA  . MET   A 1 343 ? -9.660  -43.523 -37.246 1.00 43.77 ? 343 MET   A CA  1 
ATOM   2365 C C   . MET   A 1 343 ? -10.166 -42.089 -37.319 1.00 43.04 ? 343 MET   A C   1 
ATOM   2366 O O   . MET   A 1 343 ? -11.226 -41.770 -36.767 1.00 42.56 ? 343 MET   A O   1 
ATOM   2367 C CB  . MET   A 1 343 ? -8.630  -43.675 -36.131 1.00 43.34 ? 343 MET   A CB  1 
ATOM   2368 C CG  . MET   A 1 343 ? -8.348  -45.119 -35.749 1.00 43.63 ? 343 MET   A CG  1 
ATOM   2369 S SD  . MET   A 1 343 ? -6.976  -45.265 -34.591 1.00 53.26 ? 343 MET   A SD  1 
ATOM   2370 C CE  . MET   A 1 343 ? -7.499  -44.121 -33.322 1.00 43.28 ? 343 MET   A CE  1 
ATOM   2371 N N   . LEU   A 1 344 ? -9.417  -41.209 -37.989 1.00 43.58 ? 344 LEU   A N   1 
ATOM   2372 C CA  . LEU   A 1 344 ? -9.882  -39.840 -38.183 1.00 40.60 ? 344 LEU   A CA  1 
ATOM   2373 C C   . LEU   A 1 344 ? -11.139 -39.801 -39.039 1.00 41.12 ? 344 LEU   A C   1 
ATOM   2374 O O   . LEU   A 1 344 ? -11.984 -38.918 -38.860 1.00 41.95 ? 344 LEU   A O   1 
ATOM   2375 C CB  . LEU   A 1 344 ? -8.779  -38.992 -38.815 1.00 37.72 ? 344 LEU   A CB  1 
ATOM   2376 C CG  . LEU   A 1 344 ? -7.540  -38.756 -37.947 1.00 44.12 ? 344 LEU   A CG  1 
ATOM   2377 C CD1 . LEU   A 1 344 ? -6.465  -38.023 -38.731 1.00 43.84 ? 344 LEU   A CD1 1 
ATOM   2378 C CD2 . LEU   A 1 344 ? -7.908  -37.985 -36.690 1.00 42.12 ? 344 LEU   A CD2 1 
ATOM   2379 N N   . ASP   A 1 345 ? -11.278 -40.743 -39.975 1.00 41.33 ? 345 ASP   A N   1 
ATOM   2380 C CA  . ASP   A 1 345 ? -12.527 -40.864 -40.719 1.00 43.02 ? 345 ASP   A CA  1 
ATOM   2381 C C   . ASP   A 1 345 ? -13.667 -41.279 -39.803 1.00 43.22 ? 345 ASP   A C   1 
ATOM   2382 O O   . ASP   A 1 345 ? -14.795 -40.796 -39.946 1.00 44.82 ? 345 ASP   A O   1 
ATOM   2383 C CB  . ASP   A 1 345 ? -12.372 -41.872 -41.858 1.00 43.41 ? 345 ASP   A CB  1 
ATOM   2384 C CG  . ASP   A 1 345 ? -11.553 -41.329 -43.001 1.00 45.67 ? 345 ASP   A CG  1 
ATOM   2385 O OD1 . ASP   A 1 345 ? -11.596 -40.103 -43.223 1.00 45.34 ? 345 ASP   A OD1 1 
ATOM   2386 O OD2 . ASP   A 1 345 ? -10.870 -42.123 -43.681 1.00 42.10 ? 345 ASP   A OD2 1 
ATOM   2387 N N   . ASP   A 1 346 ? -13.391 -42.182 -38.860 1.00 41.90 ? 346 ASP   A N   1 
ATOM   2388 C CA  . ASP   A 1 346 ? -14.410 -42.577 -37.895 1.00 42.16 ? 346 ASP   A CA  1 
ATOM   2389 C C   . ASP   A 1 346 ? -14.850 -41.389 -37.053 1.00 43.48 ? 346 ASP   A C   1 
ATOM   2390 O O   . ASP   A 1 346 ? -16.021 -41.288 -36.670 1.00 43.57 ? 346 ASP   A O   1 
ATOM   2391 C CB  . ASP   A 1 346 ? -13.884 -43.697 -36.998 1.00 43.90 ? 346 ASP   A CB  1 
ATOM   2392 C CG  . ASP   A 1 346 ? -13.636 -44.987 -37.755 1.00 49.17 ? 346 ASP   A CG  1 
ATOM   2393 O OD1 . ASP   A 1 346 ? -14.197 -45.156 -38.856 1.00 51.63 ? 346 ASP   A OD1 1 
ATOM   2394 O OD2 . ASP   A 1 346 ? -12.887 -45.839 -37.237 1.00 49.45 ? 346 ASP   A OD2 1 
ATOM   2395 N N   . GLN   A 1 347 ? -13.923 -40.475 -36.760 1.00 41.63 ? 347 GLN   A N   1 
ATOM   2396 C CA  . GLN   A 1 347 ? -14.270 -39.285 -35.993 1.00 41.46 ? 347 GLN   A CA  1 
ATOM   2397 C C   . GLN   A 1 347 ? -15.164 -38.356 -36.802 1.00 41.93 ? 347 GLN   A C   1 
ATOM   2398 O O   . GLN   A 1 347 ? -16.203 -37.899 -36.315 1.00 40.72 ? 347 GLN   A O   1 
ATOM   2399 C CB  . GLN   A 1 347 ? -13.001 -38.558 -35.549 1.00 43.77 ? 347 GLN   A CB  1 
ATOM   2400 C CG  . GLN   A 1 347 ? -13.271 -37.292 -34.758 1.00 43.16 ? 347 GLN   A CG  1 
ATOM   2401 C CD  . GLN   A 1 347 ? -12.003 -36.617 -34.280 1.00 44.02 ? 347 GLN   A CD  1 
ATOM   2402 O OE1 . GLN   A 1 347 ? -10.950 -36.726 -34.909 1.00 44.09 ? 347 GLN   A OE1 1 
ATOM   2403 N NE2 . GLN   A 1 347 ? -12.097 -35.914 -33.157 1.00 43.85 ? 347 GLN   A NE2 1 
ATOM   2404 N N   . ALA   A 1 348 ? -14.775 -38.069 -38.047 1.00 42.34 ? 348 ALA   A N   1 
ATOM   2405 C CA  . ALA   A 1 348 ? -15.578 -37.203 -38.905 1.00 42.92 ? 348 ALA   A CA  1 
ATOM   2406 C C   . ALA   A 1 348 ? -16.968 -37.779 -39.140 1.00 42.87 ? 348 ALA   A C   1 
ATOM   2407 O O   . ALA   A 1 348 ? -17.935 -37.023 -39.284 1.00 43.09 ? 348 ALA   A O   1 
ATOM   2408 C CB  . ALA   A 1 348 ? -14.863 -36.974 -40.239 1.00 38.70 ? 348 ALA   A CB  1 
ATOM   2409 N N   . ARG   A 1 349 ? -17.087 -39.108 -39.182 1.00 40.34 ? 349 ARG   A N   1 
ATOM   2410 C CA  . ARG   A 1 349 ? -18.401 -39.732 -39.297 1.00 41.02 ? 349 ARG   A CA  1 
ATOM   2411 C C   . ARG   A 1 349 ? -19.253 -39.441 -38.067 1.00 42.32 ? 349 ARG   A C   1 
ATOM   2412 O O   . ARG   A 1 349 ? -20.452 -39.162 -38.183 1.00 40.44 ? 349 ARG   A O   1 
ATOM   2413 C CB  . ARG   A 1 349 ? -18.243 -41.239 -39.503 1.00 40.95 ? 349 ARG   A CB  1 
ATOM   2414 C CG  . ARG   A 1 349 ? -19.537 -41.978 -39.795 1.00 41.64 ? 349 ARG   A CG  1 
ATOM   2415 C CD  . ARG   A 1 349 ? -19.294 -43.462 -40.061 1.00 39.69 ? 349 ARG   A CD  1 
ATOM   2416 N NE  . ARG   A 1 349 ? -18.252 -43.691 -41.056 1.00 42.13 ? 349 ARG   A NE  1 
ATOM   2417 C CZ  . ARG   A 1 349 ? -17.032 -44.131 -40.777 1.00 44.07 ? 349 ARG   A CZ  1 
ATOM   2418 N NH1 . ARG   A 1 349 ? -16.669 -44.418 -39.538 1.00 43.18 ? 349 ARG   A NH1 1 
ATOM   2419 N NH2 . ARG   A 1 349 ? -16.157 -44.291 -41.765 1.00 46.02 ? 349 ARG   A NH2 1 
ATOM   2420 N N   . MET   A 1 350 ? -18.646 -39.497 -36.878 1.00 44.93 ? 350 MET   A N   1 
ATOM   2421 C CA  . MET   A 1 350 ? -19.372 -39.175 -35.654 1.00 41.98 ? 350 MET   A CA  1 
ATOM   2422 C C   . MET   A 1 350 ? -19.713 -37.692 -35.590 1.00 41.36 ? 350 MET   A C   1 
ATOM   2423 O O   . MET   A 1 350 ? -20.778 -37.315 -35.087 1.00 39.37 ? 350 MET   A O   1 
ATOM   2424 C CB  . MET   A 1 350 ? -18.548 -39.589 -34.434 1.00 42.19 ? 350 MET   A CB  1 
ATOM   2425 C CG  . MET   A 1 350 ? -19.278 -39.467 -33.114 1.00 48.73 ? 350 MET   A CG  1 
ATOM   2426 S SD  . MET   A 1 350 ? -20.599 -40.677 -32.949 1.00 53.25 ? 350 MET   A SD  1 
ATOM   2427 C CE  . MET   A 1 350 ? -19.669 -42.205 -33.014 1.00 44.34 ? 350 MET   A CE  1 
ATOM   2428 N N   . MET   A 1 351 ? -18.819 -36.836 -36.095 1.00 42.53 ? 351 MET   A N   1 
ATOM   2429 C CA  . MET   A 1 351 ? -19.087 -35.401 -36.114 1.00 42.66 ? 351 MET   A CA  1 
ATOM   2430 C C   . MET   A 1 351 ? -20.297 -35.079 -36.982 1.00 44.21 ? 351 MET   A C   1 
ATOM   2431 O O   . MET   A 1 351 ? -21.124 -34.231 -36.622 1.00 44.91 ? 351 MET   A O   1 
ATOM   2432 C CB  . MET   A 1 351 ? -17.854 -34.649 -36.615 1.00 42.90 ? 351 MET   A CB  1 
ATOM   2433 C CG  . MET   A 1 351 ? -16.624 -34.812 -35.740 1.00 45.82 ? 351 MET   A CG  1 
ATOM   2434 S SD  . MET   A 1 351 ? -15.135 -34.097 -36.467 1.00 48.52 ? 351 MET   A SD  1 
ATOM   2435 C CE  . MET   A 1 351 ? -15.653 -32.400 -36.705 1.00 43.03 ? 351 MET   A CE  1 
ATOM   2436 N N   . ARG   A 1 352 ? -20.415 -35.746 -38.133 1.00 39.82 ? 352 ARG   A N   1 
ATOM   2437 C CA  . ARG   A 1 352 ? -21.592 -35.568 -38.973 1.00 42.61 ? 352 ARG   A CA  1 
ATOM   2438 C C   . ARG   A 1 352 ? -22.844 -36.097 -38.291 1.00 40.40 ? 352 ARG   A C   1 
ATOM   2439 O O   . ARG   A 1 352 ? -23.940 -35.574 -38.516 1.00 41.07 ? 352 ARG   A O   1 
ATOM   2440 C CB  . ARG   A 1 352 ? -21.385 -36.260 -40.320 1.00 43.16 ? 352 ARG   A CB  1 
ATOM   2441 C CG  . ARG   A 1 352 ? -20.266 -35.659 -41.149 1.00 43.71 ? 352 ARG   A CG  1 
ATOM   2442 C CD  . ARG   A 1 352 ? -20.330 -36.144 -42.583 1.00 44.78 ? 352 ARG   A CD  1 
ATOM   2443 N NE  . ARG   A 1 352 ? -20.322 -37.599 -42.663 1.00 47.55 ? 352 ARG   A NE  1 
ATOM   2444 C CZ  . ARG   A 1 352 ? -19.224 -38.338 -42.715 1.00 45.33 ? 352 ARG   A CZ  1 
ATOM   2445 N NH1 . ARG   A 1 352 ? -18.021 -37.791 -42.676 1.00 42.89 ? 352 ARG   A NH1 1 
ATOM   2446 N NH2 . ARG   A 1 352 ? -19.335 -39.660 -42.812 1.00 41.08 ? 352 ARG   A NH2 1 
ATOM   2447 N N   . ALA   A 1 353 ? -22.704 -37.130 -37.457 1.00 41.23 ? 353 ALA   A N   1 
ATOM   2448 C CA  . ALA   A 1 353 ? -23.856 -37.639 -36.722 1.00 42.74 ? 353 ALA   A CA  1 
ATOM   2449 C C   . ALA   A 1 353 ? -24.369 -36.603 -35.734 1.00 43.60 ? 353 ALA   A C   1 
ATOM   2450 O O   . ALA   A 1 353 ? -25.583 -36.444 -35.561 1.00 40.90 ? 353 ALA   A O   1 
ATOM   2451 C CB  . ALA   A 1 353 ? -23.492 -38.937 -36.002 1.00 38.56 ? 353 ALA   A CB  1 
ATOM   2452 N N   . PHE   A 1 354 ? -23.457 -35.881 -35.081 1.00 39.39 ? 354 PHE   A N   1 
ATOM   2453 C CA  . PHE   A 1 354 ? -23.871 -34.774 -34.229 1.00 43.94 ? 354 PHE   A CA  1 
ATOM   2454 C C   . PHE   A 1 354 ? -24.399 -33.603 -35.045 1.00 42.84 ? 354 PHE   A C   1 
ATOM   2455 O O   . PHE   A 1 354 ? -25.207 -32.818 -34.539 1.00 41.86 ? 354 PHE   A O   1 
ATOM   2456 C CB  . PHE   A 1 354 ? -22.712 -34.323 -33.341 1.00 40.64 ? 354 PHE   A CB  1 
ATOM   2457 C CG  . PHE   A 1 354 ? -22.582 -35.112 -32.073 1.00 40.46 ? 354 PHE   A CG  1 
ATOM   2458 C CD1 . PHE   A 1 354 ? -23.536 -34.998 -31.076 1.00 40.99 ? 354 PHE   A CD1 1 
ATOM   2459 C CD2 . PHE   A 1 354 ? -21.508 -35.964 -31.873 1.00 40.86 ? 354 PHE   A CD2 1 
ATOM   2460 C CE1 . PHE   A 1 354 ? -23.427 -35.722 -29.902 1.00 38.90 ? 354 PHE   A CE1 1 
ATOM   2461 C CE2 . PHE   A 1 354 ? -21.393 -36.692 -30.701 1.00 43.52 ? 354 PHE   A CE2 1 
ATOM   2462 C CZ  . PHE   A 1 354 ? -22.354 -36.570 -29.715 1.00 38.40 ? 354 PHE   A CZ  1 
ATOM   2463 N N   . ASP   A 1 355 ? -23.952 -33.457 -36.295 1.00 45.15 ? 355 ASP   A N   1 
ATOM   2464 C CA  . ASP   A 1 355 ? -24.510 -32.412 -37.148 1.00 45.11 ? 355 ASP   A CA  1 
ATOM   2465 C C   . ASP   A 1 355 ? -25.999 -32.636 -37.376 1.00 45.37 ? 355 ASP   A C   1 
ATOM   2466 O O   . ASP   A 1 355 ? -26.787 -31.684 -37.347 1.00 48.66 ? 355 ASP   A O   1 
ATOM   2467 C CB  . ASP   A 1 355 ? -23.765 -32.352 -38.483 1.00 45.98 ? 355 ASP   A CB  1 
ATOM   2468 C CG  . ASP   A 1 355 ? -22.397 -31.706 -38.364 1.00 50.76 ? 355 ASP   A CG  1 
ATOM   2469 O OD1 . ASP   A 1 355 ? -22.270 -30.697 -37.638 1.00 53.77 ? 355 ASP   A OD1 1 
ATOM   2470 O OD2 . ASP   A 1 355 ? -21.448 -32.207 -39.001 1.00 52.17 ? 355 ASP   A OD2 1 
ATOM   2471 N N   . ARG   A 1 356 ? -26.406 -33.891 -37.588 1.00 46.00 ? 356 ARG   A N   1 
ATOM   2472 C CA  . ARG   A 1 356 ? -27.826 -34.180 -37.762 1.00 49.86 ? 356 ARG   A CA  1 
ATOM   2473 C C   . ARG   A 1 356 ? -28.598 -33.971 -36.464 1.00 48.61 ? 356 ARG   A C   1 
ATOM   2474 O O   . ARG   A 1 356 ? -29.741 -33.499 -36.485 1.00 51.78 ? 356 ARG   A O   1 
ATOM   2475 C CB  . ARG   A 1 356 ? -28.015 -35.607 -38.271 1.00 53.36 ? 356 ARG   A CB  1 
ATOM   2476 C CG  . ARG   A 1 356 ? -29.467 -35.981 -38.488 1.00 59.95 ? 356 ARG   A CG  1 
ATOM   2477 C CD  . ARG   A 1 356 ? -29.620 -37.383 -39.049 1.00 63.68 ? 356 ARG   A CD  1 
ATOM   2478 N NE  . ARG   A 1 356 ? -31.016 -37.679 -39.351 1.00 70.35 ? 356 ARG   A NE  1 
ATOM   2479 C CZ  . ARG   A 1 356 ? -31.608 -37.419 -40.508 1.00 72.86 ? 356 ARG   A CZ  1 
ATOM   2480 N NH1 . ARG   A 1 356 ? -30.948 -36.870 -41.513 1.00 66.11 ? 356 ARG   A NH1 1 
ATOM   2481 N NH2 . ARG   A 1 356 ? -32.894 -37.720 -40.661 1.00 73.53 ? 356 ARG   A NH2 1 
ATOM   2482 N N   . LEU   A 1 357 ? -27.989 -34.317 -35.327 1.00 45.99 ? 357 LEU   A N   1 
ATOM   2483 C CA  . LEU   A 1 357 ? -28.649 -34.126 -34.039 1.00 44.92 ? 357 LEU   A CA  1 
ATOM   2484 C C   . LEU   A 1 357 ? -28.923 -32.652 -33.775 1.00 44.22 ? 357 LEU   A C   1 
ATOM   2485 O O   . LEU   A 1 357 ? -30.032 -32.274 -33.376 1.00 44.66 ? 357 LEU   A O   1 
ATOM   2486 C CB  . LEU   A 1 357 ? -27.794 -34.717 -32.919 1.00 44.58 ? 357 LEU   A CB  1 
ATOM   2487 C CG  . LEU   A 1 357 ? -28.267 -34.396 -31.501 1.00 44.37 ? 357 LEU   A CG  1 
ATOM   2488 C CD1 . LEU   A 1 357 ? -29.490 -35.228 -31.139 1.00 42.72 ? 357 LEU   A CD1 1 
ATOM   2489 C CD2 . LEU   A 1 357 ? -27.152 -34.600 -30.489 1.00 45.62 ? 357 LEU   A CD2 1 
ATOM   2490 N N   . PHE   A 1 358 ? -27.920 -31.801 -33.993 1.00 44.14 ? 358 PHE   A N   1 
ATOM   2491 C CA  . PHE   A 1 358 ? -28.080 -30.376 -33.734 1.00 44.80 ? 358 PHE   A CA  1 
ATOM   2492 C C   . PHE   A 1 358 ? -28.947 -29.675 -34.770 1.00 46.35 ? 358 PHE   A C   1 
ATOM   2493 O O   . PHE   A 1 358 ? -29.203 -28.475 -34.623 1.00 49.24 ? 358 PHE   A O   1 
ATOM   2494 C CB  . PHE   A 1 358 ? -26.710 -29.703 -33.640 1.00 43.48 ? 358 PHE   A CB  1 
ATOM   2495 C CG  . PHE   A 1 358 ? -26.025 -29.918 -32.320 1.00 44.51 ? 358 PHE   A CG  1 
ATOM   2496 C CD1 . PHE   A 1 358 ? -26.552 -29.378 -31.160 1.00 40.95 ? 358 PHE   A CD1 1 
ATOM   2497 C CD2 . PHE   A 1 358 ? -24.858 -30.659 -32.239 1.00 44.46 ? 358 PHE   A CD2 1 
ATOM   2498 C CE1 . PHE   A 1 358 ? -25.932 -29.575 -29.941 1.00 43.60 ? 358 PHE   A CE1 1 
ATOM   2499 C CE2 . PHE   A 1 358 ? -24.231 -30.859 -31.022 1.00 41.17 ? 358 PHE   A CE2 1 
ATOM   2500 C CZ  . PHE   A 1 358 ? -24.769 -30.316 -29.872 1.00 41.04 ? 358 PHE   A CZ  1 
ATOM   2501 N N   . GLU   A 1 359 ? -29.403 -30.379 -35.807 1.00 47.91 ? 359 GLU   A N   1 
ATOM   2502 C CA  . GLU   A 1 359 ? -30.464 -29.839 -36.646 1.00 50.17 ? 359 GLU   A CA  1 
ATOM   2503 C C   . GLU   A 1 359 ? -31.811 -29.879 -35.941 1.00 48.82 ? 359 GLU   A C   1 
ATOM   2504 O O   . GLU   A 1 359 ? -32.740 -29.179 -36.358 1.00 49.32 ? 359 GLU   A O   1 
ATOM   2505 C CB  . GLU   A 1 359 ? -30.543 -30.609 -37.965 1.00 48.05 ? 359 GLU   A CB  1 
ATOM   2506 C CG  . GLU   A 1 359 ? -29.318 -30.451 -38.849 1.00 52.14 ? 359 GLU   A CG  1 
ATOM   2507 C CD  . GLU   A 1 359 ? -29.337 -31.388 -40.037 1.00 56.70 ? 359 GLU   A CD  1 
ATOM   2508 O OE1 . GLU   A 1 359 ? -30.242 -32.244 -40.104 1.00 56.96 ? 359 GLU   A OE1 1 
ATOM   2509 O OE2 . GLU   A 1 359 ? -28.448 -31.272 -40.906 1.00 57.20 ? 359 GLU   A OE2 1 
ATOM   2510 N N   . SER   A 1 360 ? -31.933 -30.686 -34.884 1.00 44.57 ? 360 SER   A N   1 
ATOM   2511 C CA  . SER   A 1 360 ? -33.163 -30.816 -34.120 1.00 46.26 ? 360 SER   A CA  1 
ATOM   2512 C C   . SER   A 1 360 ? -33.096 -30.162 -32.749 1.00 47.86 ? 360 SER   A C   1 
ATOM   2513 O O   . SER   A 1 360 ? -34.147 -29.870 -32.170 1.00 48.54 ? 360 SER   A O   1 
ATOM   2514 C CB  . SER   A 1 360 ? -33.519 -32.300 -33.939 1.00 47.30 ? 360 SER   A CB  1 
ATOM   2515 O OG  . SER   A 1 360 ? -33.251 -33.038 -35.119 1.00 52.55 ? 360 SER   A OG  1 
ATOM   2516 N N   . PHE   A 1 361 ? -31.898 -29.929 -32.218 1.00 47.47 ? 361 PHE   A N   1 
ATOM   2517 C CA  . PHE   A 1 361 ? -31.728 -29.362 -30.891 1.00 46.36 ? 361 PHE   A CA  1 
ATOM   2518 C C   . PHE   A 1 361 ? -30.721 -28.225 -30.941 1.00 45.45 ? 361 PHE   A C   1 
ATOM   2519 O O   . PHE   A 1 361 ? -29.846 -28.181 -31.811 1.00 49.52 ? 361 PHE   A O   1 
ATOM   2520 C CB  . PHE   A 1 361 ? -31.258 -30.418 -29.882 1.00 45.35 ? 361 PHE   A CB  1 
ATOM   2521 C CG  . PHE   A 1 361 ? -32.202 -31.571 -29.730 1.00 45.41 ? 361 PHE   A CG  1 
ATOM   2522 C CD1 . PHE   A 1 361 ? -33.279 -31.489 -28.865 1.00 41.79 ? 361 PHE   A CD1 1 
ATOM   2523 C CD2 . PHE   A 1 361 ? -32.014 -32.735 -30.455 1.00 43.86 ? 361 PHE   A CD2 1 
ATOM   2524 C CE1 . PHE   A 1 361 ? -34.153 -32.550 -28.724 1.00 43.31 ? 361 PHE   A CE1 1 
ATOM   2525 C CE2 . PHE   A 1 361 ? -32.884 -33.801 -30.319 1.00 45.30 ? 361 PHE   A CE2 1 
ATOM   2526 C CZ  . PHE   A 1 361 ? -33.956 -33.708 -29.451 1.00 46.03 ? 361 PHE   A CZ  1 
ATOM   2527 N N   . ASP   A 1 362 ? -30.860 -27.303 -29.991 1.00 46.37 ? 362 ASP   A N   1 
ATOM   2528 C CA  . ASP   A 1 362 ? -29.931 -26.194 -29.839 1.00 46.97 ? 362 ASP   A CA  1 
ATOM   2529 C C   . ASP   A 1 362 ? -28.826 -26.478 -28.831 1.00 46.66 ? 362 ASP   A C   1 
ATOM   2530 O O   . ASP   A 1 362 ? -27.746 -25.886 -28.935 1.00 47.22 ? 362 ASP   A O   1 
ATOM   2531 C CB  . ASP   A 1 362 ? -30.686 -24.932 -29.411 1.00 48.14 ? 362 ASP   A CB  1 
ATOM   2532 C CG  . ASP   A 1 362 ? -31.743 -24.514 -30.415 1.00 51.74 ? 362 ASP   A CG  1 
ATOM   2533 O OD1 . ASP   A 1 362 ? -31.373 -24.154 -31.551 1.00 53.26 ? 362 ASP   A OD1 1 
ATOM   2534 O OD2 . ASP   A 1 362 ? -32.943 -24.556 -30.070 1.00 53.02 ? 362 ASP   A OD2 1 
ATOM   2535 N N   . ALA   A 1 363 ? -29.064 -27.361 -27.863 1.00 44.22 ? 363 ALA   A N   1 
ATOM   2536 C CA  . ALA   A 1 363 ? -28.063 -27.642 -26.841 1.00 44.88 ? 363 ALA   A CA  1 
ATOM   2537 C C   . ALA   A 1 363 ? -28.405 -28.947 -26.139 1.00 46.12 ? 363 ALA   A C   1 
ATOM   2538 O O   . ALA   A 1 363 ? -29.578 -29.312 -26.013 1.00 46.52 ? 363 ALA   A O   1 
ATOM   2539 C CB  . ALA   A 1 363 ? -27.972 -26.504 -25.815 1.00 43.66 ? 363 ALA   A CB  1 
ATOM   2540 N N   . ILE   A 1 364 ? -27.365 -29.642 -25.686 1.00 45.71 ? 364 ILE   A N   1 
ATOM   2541 C CA  . ILE   A 1 364 ? -27.505 -30.833 -24.857 1.00 41.93 ? 364 ILE   A CA  1 
ATOM   2542 C C   . ILE   A 1 364 ? -27.207 -30.447 -23.417 1.00 39.22 ? 364 ILE   A C   1 
ATOM   2543 O O   . ILE   A 1 364 ? -26.166 -29.841 -23.131 1.00 41.97 ? 364 ILE   A O   1 
ATOM   2544 C CB  . ILE   A 1 364 ? -26.566 -31.960 -25.322 1.00 42.02 ? 364 ILE   A CB  1 
ATOM   2545 C CG1 . ILE   A 1 364 ? -26.951 -32.460 -26.712 1.00 41.88 ? 364 ILE   A CG1 1 
ATOM   2546 C CG2 . ILE   A 1 364 ? -26.583 -33.111 -24.325 1.00 41.49 ? 364 ILE   A CG2 1 
ATOM   2547 C CD1 . ILE   A 1 364 ? -25.970 -33.464 -27.274 1.00 39.52 ? 364 ILE   A CD1 1 
ATOM   2548 N N   . PHE   A 1 365 ? -28.120 -30.786 -22.512 1.00 41.33 ? 365 PHE   A N   1 
ATOM   2549 C CA  . PHE   A 1 365 ? -27.902 -30.624 -21.081 1.00 41.37 ? 365 PHE   A CA  1 
ATOM   2550 C C   . PHE   A 1 365 ? -27.600 -31.988 -20.475 1.00 44.70 ? 365 PHE   A C   1 
ATOM   2551 O O   . PHE   A 1 365 ? -28.386 -32.929 -20.629 1.00 44.74 ? 365 PHE   A O   1 
ATOM   2552 C CB  . PHE   A 1 365 ? -29.117 -29.995 -20.396 1.00 43.27 ? 365 PHE   A CB  1 
ATOM   2553 C CG  . PHE   A 1 365 ? -29.272 -28.515 -20.649 1.00 44.01 ? 365 PHE   A CG  1 
ATOM   2554 C CD1 . PHE   A 1 365 ? -28.485 -27.859 -21.584 1.00 44.11 ? 365 PHE   A CD1 1 
ATOM   2555 C CD2 . PHE   A 1 365 ? -30.200 -27.778 -19.931 1.00 39.82 ? 365 PHE   A CD2 1 
ATOM   2556 C CE1 . PHE   A 1 365 ? -28.634 -26.502 -21.810 1.00 41.01 ? 365 PHE   A CE1 1 
ATOM   2557 C CE2 . PHE   A 1 365 ? -30.350 -26.420 -20.149 1.00 39.87 ? 365 PHE   A CE2 1 
ATOM   2558 C CZ  . PHE   A 1 365 ? -29.567 -25.782 -21.090 1.00 43.62 ? 365 PHE   A CZ  1 
ATOM   2559 N N   . CYS   A 1 366 ? -26.463 -32.092 -19.799 1.00 43.80 ? 366 CYS   A N   1 
ATOM   2560 C CA  . CYS   A 1 366 ? -26.005 -33.356 -19.239 1.00 44.61 ? 366 CYS   A CA  1 
ATOM   2561 C C   . CYS   A 1 366 ? -25.019 -33.048 -18.120 1.00 43.24 ? 366 CYS   A C   1 
ATOM   2562 O O   . CYS   A 1 366 ? -24.531 -31.914 -18.007 1.00 41.33 ? 366 CYS   A O   1 
ATOM   2563 C CB  . CYS   A 1 366 ? -25.360 -34.243 -20.320 1.00 39.77 ? 366 CYS   A CB  1 
ATOM   2564 S SG  . CYS   A 1 366 ? -23.748 -33.670 -20.899 1.00 44.61 ? 366 CYS   A SG  1 
ATOM   2565 N N   . PRO   A 1 367 ? -24.726 -34.021 -17.258 1.00 43.24 ? 367 PRO   A N   1 
ATOM   2566 C CA  . PRO   A 1 367 ? -23.729 -33.787 -16.208 1.00 42.73 ? 367 PRO   A CA  1 
ATOM   2567 C C   . PRO   A 1 367 ? -22.322 -33.678 -16.775 1.00 42.35 ? 367 PRO   A C   1 
ATOM   2568 O O   . PRO   A 1 367 ? -21.990 -34.270 -17.805 1.00 44.86 ? 367 PRO   A O   1 
ATOM   2569 C CB  . PRO   A 1 367 ? -23.860 -35.021 -15.306 1.00 44.76 ? 367 PRO   A CB  1 
ATOM   2570 C CG  . PRO   A 1 367 ? -25.190 -35.607 -15.625 1.00 44.16 ? 367 PRO   A CG  1 
ATOM   2571 C CD  . PRO   A 1 367 ? -25.424 -35.304 -17.070 1.00 43.20 ? 367 PRO   A CD  1 
ATOM   2572 N N   . VAL   A 1 368 ? -21.492 -32.895 -16.082 1.00 39.43 ? 368 VAL   A N   1 
ATOM   2573 C CA  . VAL   A 1 368 ? -20.064 -32.872 -16.387 1.00 40.68 ? 368 VAL   A CA  1 
ATOM   2574 C C   . VAL   A 1 368 ? -19.426 -34.193 -15.982 1.00 43.73 ? 368 VAL   A C   1 
ATOM   2575 O O   . VAL   A 1 368 ? -18.687 -34.810 -16.756 1.00 41.93 ? 368 VAL   A O   1 
ATOM   2576 C CB  . VAL   A 1 368 ? -19.381 -31.683 -15.687 1.00 39.44 ? 368 VAL   A CB  1 
ATOM   2577 C CG1 . VAL   A 1 368 ? -17.877 -31.722 -15.921 1.00 35.74 ? 368 VAL   A CG1 1 
ATOM   2578 C CG2 . VAL   A 1 368 ? -19.973 -30.369 -16.166 1.00 40.25 ? 368 VAL   A CG2 1 
ATOM   2579 N N   . LEU   A 1 369 ? -19.712 -34.647 -14.766 1.00 41.52 ? 369 LEU   A N   1 
ATOM   2580 C CA  . LEU   A 1 369 ? -19.247 -35.928 -14.263 1.00 41.48 ? 369 LEU   A CA  1 
ATOM   2581 C C   . LEU   A 1 369 ? -20.352 -36.541 -13.412 1.00 44.47 ? 369 LEU   A C   1 
ATOM   2582 O O   . LEU   A 1 369 ? -21.296 -35.863 -12.998 1.00 42.07 ? 369 LEU   A O   1 
ATOM   2583 C CB  . LEU   A 1 369 ? -17.954 -35.778 -13.450 1.00 42.98 ? 369 LEU   A CB  1 
ATOM   2584 C CG  . LEU   A 1 369 ? -16.771 -36.675 -13.828 1.00 44.03 ? 369 LEU   A CG  1 
ATOM   2585 C CD1 . LEU   A 1 369 ? -16.577 -36.707 -15.334 1.00 42.00 ? 369 LEU   A CD1 1 
ATOM   2586 C CD2 . LEU   A 1 369 ? -15.514 -36.182 -13.138 1.00 42.02 ? 369 LEU   A CD2 1 
ATOM   2587 N N   . GLY   A 1 370 ? -20.228 -37.844 -13.155 1.00 43.09 ? 370 GLY   A N   1 
ATOM   2588 C CA  . GLY   A 1 370 ? -21.270 -38.548 -12.427 1.00 43.97 ? 370 GLY   A CA  1 
ATOM   2589 C C   . GLY   A 1 370 ? -21.397 -38.129 -10.977 1.00 48.05 ? 370 GLY   A C   1 
ATOM   2590 O O   . GLY   A 1 370 ? -22.482 -38.219 -10.397 1.00 49.20 ? 370 GLY   A O   1 
ATOM   2591 N N   . THR   A 1 371 ? -20.303 -37.672 -10.370 1.00 45.64 ? 371 THR   A N   1 
ATOM   2592 C CA  . THR   A 1 371 ? -20.304 -37.282 -8.969  1.00 46.70 ? 371 THR   A CA  1 
ATOM   2593 C C   . THR   A 1 371 ? -19.494 -36.005 -8.803  1.00 45.58 ? 371 THR   A C   1 
ATOM   2594 O O   . THR   A 1 371 ? -18.890 -35.496 -9.751  1.00 47.13 ? 371 THR   A O   1 
ATOM   2595 C CB  . THR   A 1 371 ? -19.735 -38.390 -8.074  1.00 49.47 ? 371 THR   A CB  1 
ATOM   2596 O OG1 . THR   A 1 371 ? -19.965 -38.063 -6.697  1.00 53.28 ? 371 THR   A OG1 1 
ATOM   2597 C CG2 . THR   A 1 371 ? -18.241 -38.541 -8.307  1.00 43.89 ? 371 THR   A CG2 1 
ATOM   2598 N N   . THR   A 1 372 ? -19.480 -35.490 -7.578  1.00 48.78 ? 372 THR   A N   1 
ATOM   2599 C CA  . THR   A 1 372 ? -18.737 -34.280 -7.268  1.00 46.76 ? 372 THR   A CA  1 
ATOM   2600 C C   . THR   A 1 372 ? -17.310 -34.645 -6.858  1.00 46.53 ? 372 THR   A C   1 
ATOM   2601 O O   . THR   A 1 372 ? -16.874 -35.790 -7.005  1.00 47.02 ? 372 THR   A O   1 
ATOM   2602 C CB  . THR   A 1 372 ? -19.468 -33.473 -6.198  1.00 45.49 ? 372 THR   A CB  1 
ATOM   2603 O OG1 . THR   A 1 372 ? -19.607 -34.257 -5.007  1.00 49.59 ? 372 THR   A OG1 1 
ATOM   2604 C CG2 . THR   A 1 372 ? -20.845 -33.075 -6.699  1.00 44.09 ? 372 THR   A CG2 1 
ATOM   2605 N N   . ALA   A 1 373 ? -16.573 -33.664 -6.331  1.00 40.51 ? 373 ALA   A N   1 
ATOM   2606 C CA  . ALA   A 1 373 ? -15.147 -33.832 -6.074  1.00 41.45 ? 373 ALA   A CA  1 
ATOM   2607 C C   . ALA   A 1 373 ? -14.885 -35.016 -5.150  1.00 44.31 ? 373 ALA   A C   1 
ATOM   2608 O O   . ALA   A 1 373 ? -15.445 -35.102 -4.054  1.00 47.41 ? 373 ALA   A O   1 
ATOM   2609 C CB  . ALA   A 1 373 ? -14.570 -32.554 -5.467  1.00 40.28 ? 373 ALA   A CB  1 
ATOM   2610 N N   . PHE   A 1 374 ? -14.024 -35.925 -5.601  1.00 41.69 ? 374 PHE   A N   1 
ATOM   2611 C CA  . PHE   A 1 374 ? -13.648 -37.104 -4.836  1.00 46.10 ? 374 PHE   A CA  1 
ATOM   2612 C C   . PHE   A 1 374 ? -12.472 -36.800 -3.912  1.00 45.09 ? 374 PHE   A C   1 
ATOM   2613 O O   . PHE   A 1 374 ? -11.765 -35.802 -4.069  1.00 45.93 ? 374 PHE   A O   1 
ATOM   2614 C CB  . PHE   A 1 374 ? -13.296 -38.269 -5.769  1.00 45.88 ? 374 PHE   A CB  1 
ATOM   2615 C CG  . PHE   A 1 374 ? -12.224 -37.948 -6.785  1.00 44.37 ? 374 PHE   A CG  1 
ATOM   2616 C CD1 . PHE   A 1 374 ? -10.879 -38.076 -6.468  1.00 42.85 ? 374 PHE   A CD1 1 
ATOM   2617 C CD2 . PHE   A 1 374 ? -12.564 -37.535 -8.065  1.00 43.04 ? 374 PHE   A CD2 1 
ATOM   2618 C CE1 . PHE   A 1 374 ? -9.896  -37.787 -7.401  1.00 45.30 ? 374 PHE   A CE1 1 
ATOM   2619 C CE2 . PHE   A 1 374 ? -11.585 -37.247 -9.003  1.00 41.00 ? 374 PHE   A CE2 1 
ATOM   2620 C CZ  . PHE   A 1 374 ? -10.252 -37.374 -8.669  1.00 39.86 ? 374 PHE   A CZ  1 
ATOM   2621 N N   . ALA   A 1 375 ? -12.267 -37.687 -2.941  1.00 44.31 ? 375 ALA   A N   1 
ATOM   2622 C CA  . ALA   A 1 375 ? -11.176 -37.525 -1.992  1.00 46.41 ? 375 ALA   A CA  1 
ATOM   2623 C C   . ALA   A 1 375 ? -9.830  -37.733 -2.677  1.00 45.35 ? 375 ALA   A C   1 
ATOM   2624 O O   . ALA   A 1 375 ? -9.724  -38.427 -3.691  1.00 46.88 ? 375 ALA   A O   1 
ATOM   2625 C CB  . ALA   A 1 375 ? -11.329 -38.505 -0.830  1.00 46.53 ? 375 ALA   A CB  1 
ATOM   2626 N N   . HIS   A 1 376 ? -8.793  -37.122 -2.105  1.00 44.54 ? 376 HIS   A N   1 
ATOM   2627 C CA  . HIS   A 1 376 ? -7.456  -37.188 -2.683  1.00 43.54 ? 376 HIS   A CA  1 
ATOM   2628 C C   . HIS   A 1 376 ? -7.013  -38.632 -2.874  1.00 45.24 ? 376 HIS   A C   1 
ATOM   2629 O O   . HIS   A 1 376 ? -7.149  -39.463 -1.973  1.00 45.87 ? 376 HIS   A O   1 
ATOM   2630 C CB  . HIS   A 1 376 ? -6.457  -36.448 -1.789  1.00 45.30 ? 376 HIS   A CB  1 
ATOM   2631 C CG  . HIS   A 1 376 ? -6.761  -34.993 -1.611  1.00 42.41 ? 376 HIS   A CG  1 
ATOM   2632 N ND1 . HIS   A 1 376 ? -6.594  -34.068 -2.618  1.00 43.07 ? 376 HIS   A ND1 1 
ATOM   2633 C CD2 . HIS   A 1 376 ? -7.207  -34.302 -0.535  1.00 42.99 ? 376 HIS   A CD2 1 
ATOM   2634 C CE1 . HIS   A 1 376 ? -6.930  -32.870 -2.172  1.00 42.44 ? 376 HIS   A CE1 1 
ATOM   2635 N NE2 . HIS   A 1 376 ? -7.305  -32.985 -0.911  1.00 41.37 ? 376 HIS   A NE2 1 
ATOM   2636 N N   . SER   A 1 377 ? -6.486  -38.925 -4.057  1.00 44.66 ? 377 SER   A N   1 
ATOM   2637 C CA  . SER   A 1 377 ? -5.980  -40.249 -4.387  1.00 47.87 ? 377 SER   A CA  1 
ATOM   2638 C C   . SER   A 1 377 ? -4.477  -40.183 -4.616  1.00 48.32 ? 377 SER   A C   1 
ATOM   2639 O O   . SER   A 1 377 ? -3.968  -39.216 -5.191  1.00 46.08 ? 377 SER   A O   1 
ATOM   2640 C CB  . SER   A 1 377 ? -6.672  -40.816 -5.630  1.00 48.83 ? 377 SER   A CB  1 
ATOM   2641 O OG  . SER   A 1 377 ? -6.168  -42.104 -5.945  1.00 48.41 ? 377 SER   A OG  1 
ATOM   2642 N N   . ASP   A 1 378 ? -3.769  -41.210 -4.152  1.00 52.21 ? 378 ASP   A N   1 
ATOM   2643 C CA  . ASP   A 1 378 ? -2.336  -41.327 -4.374  1.00 52.36 ? 378 ASP   A CA  1 
ATOM   2644 C C   . ASP   A 1 378 ? -2.006  -42.320 -5.477  1.00 52.69 ? 378 ASP   A C   1 
ATOM   2645 O O   . ASP   A 1 378 ? -0.827  -42.596 -5.718  1.00 56.00 ? 378 ASP   A O   1 
ATOM   2646 C CB  . ASP   A 1 378 ? -1.627  -41.729 -3.079  1.00 59.06 ? 378 ASP   A CB  1 
ATOM   2647 C CG  . ASP   A 1 378 ? -1.852  -43.185 -2.716  1.00 60.91 ? 378 ASP   A CG  1 
ATOM   2648 O OD1 . ASP   A 1 378 ? -2.975  -43.688 -2.924  1.00 54.26 ? 378 ASP   A OD1 1 
ATOM   2649 O OD2 . ASP   A 1 378 ? -0.903  -43.829 -2.223  1.00 63.98 ? 378 ASP   A OD2 1 
ATOM   2650 N N   . GLU   A 1 379 ? -3.020  -42.868 -6.144  1.00 52.40 ? 379 GLU   A N   1 
ATOM   2651 C CA  . GLU   A 1 379 ? -2.810  -43.875 -7.170  1.00 52.25 ? 379 GLU   A CA  1 
ATOM   2652 C C   . GLU   A 1 379 ? -2.836  -43.221 -8.541  1.00 52.49 ? 379 GLU   A C   1 
ATOM   2653 O O   . GLU   A 1 379 ? -3.900  -42.747 -8.969  1.00 51.41 ? 379 GLU   A O   1 
ATOM   2654 C CB  . GLU   A 1 379 ? -3.878  -44.963 -7.079  1.00 50.31 ? 379 GLU   A CB  1 
ATOM   2655 C CG  . GLU   A 1 379 ? -3.802  -45.983 -8.197  1.00 50.87 ? 379 GLU   A CG  1 
ATOM   2656 C CD  . GLU   A 1 379 ? -2.449  -46.662 -8.268  1.00 53.56 ? 379 GLU   A CD  1 
ATOM   2657 O OE1 . GLU   A 1 379 ? -2.055  -47.302 -7.273  1.00 54.48 ? 379 GLU   A OE1 1 
ATOM   2658 O OE2 . GLU   A 1 379 ? -1.776  -46.546 -9.313  1.00 54.31 ? 379 GLU   A OE2 1 
ATOM   2659 N N   . PRO   A 1 380 ? -1.714  -43.166 -9.264  1.00 53.44 ? 380 PRO   A N   1 
ATOM   2660 C CA  . PRO   A 1 380 ? -1.745  -42.548 -10.599 1.00 51.14 ? 380 PRO   A CA  1 
ATOM   2661 C C   . PRO   A 1 380 ? -2.587  -43.321 -11.598 1.00 51.72 ? 380 PRO   A C   1 
ATOM   2662 O O   . PRO   A 1 380 ? -3.275  -42.713 -12.428 1.00 54.50 ? 380 PRO   A O   1 
ATOM   2663 C CB  . PRO   A 1 380 ? -0.261  -42.519 -11.006 1.00 48.79 ? 380 PRO   A CB  1 
ATOM   2664 C CG  . PRO   A 1 380 ? 0.500   -42.674 -9.722  1.00 55.17 ? 380 PRO   A CG  1 
ATOM   2665 C CD  . PRO   A 1 380 ? -0.352  -43.562 -8.874  1.00 53.68 ? 380 PRO   A CD  1 
ATOM   2666 N N   . ASP   A 1 381 ? -2.561  -44.649 -11.534 1.00 49.41 ? 381 ASP   A N   1 
ATOM   2667 C CA  . ASP   A 1 381 ? -3.273  -45.469 -12.506 1.00 49.43 ? 381 ASP   A CA  1 
ATOM   2668 C C   . ASP   A 1 381 ? -4.776  -45.379 -12.269 1.00 51.76 ? 381 ASP   A C   1 
ATOM   2669 O O   . ASP   A 1 381 ? -5.266  -45.751 -11.197 1.00 55.62 ? 381 ASP   A O   1 
ATOM   2670 C CB  . ASP   A 1 381 ? -2.796  -46.916 -12.415 1.00 52.32 ? 381 ASP   A CB  1 
ATOM   2671 C CG  . ASP   A 1 381 ? -3.246  -47.754 -13.593 1.00 54.10 ? 381 ASP   A CG  1 
ATOM   2672 O OD1 . ASP   A 1 381 ? -3.992  -47.238 -14.452 1.00 51.89 ? 381 ASP   A OD1 1 
ATOM   2673 O OD2 . ASP   A 1 381 ? -2.844  -48.933 -13.663 1.00 58.51 ? 381 ASP   A OD2 1 
ATOM   2674 N N   . TRP   A 1 382 ? -5.508  -44.884 -13.272 1.00 50.39 ? 382 TRP   A N   1 
ATOM   2675 C CA  . TRP   A 1 382 ? -6.960  -44.814 -13.150 1.00 49.79 ? 382 TRP   A CA  1 
ATOM   2676 C C   . TRP   A 1 382 ? -7.585  -46.200 -13.056 1.00 50.24 ? 382 TRP   A C   1 
ATOM   2677 O O   . TRP   A 1 382 ? -8.601  -46.377 -12.375 1.00 50.74 ? 382 TRP   A O   1 
ATOM   2678 C CB  . TRP   A 1 382 ? -7.556  -44.050 -14.330 1.00 54.41 ? 382 TRP   A CB  1 
ATOM   2679 C CG  . TRP   A 1 382 ? -7.461  -42.563 -14.207 1.00 51.92 ? 382 TRP   A CG  1 
ATOM   2680 C CD1 . TRP   A 1 382 ? -6.647  -41.857 -13.372 1.00 51.14 ? 382 TRP   A CD1 1 
ATOM   2681 C CD2 . TRP   A 1 382 ? -8.222  -41.597 -14.938 1.00 49.16 ? 382 TRP   A CD2 1 
ATOM   2682 N NE1 . TRP   A 1 382 ? -6.848  -40.508 -13.545 1.00 51.31 ? 382 TRP   A NE1 1 
ATOM   2683 C CE2 . TRP   A 1 382 ? -7.811  -40.324 -14.502 1.00 50.38 ? 382 TRP   A CE2 1 
ATOM   2684 C CE3 . TRP   A 1 382 ? -9.207  -41.686 -15.927 1.00 49.05 ? 382 TRP   A CE3 1 
ATOM   2685 C CZ2 . TRP   A 1 382 ? -8.348  -39.149 -15.020 1.00 49.03 ? 382 TRP   A CZ2 1 
ATOM   2686 C CZ3 . TRP   A 1 382 ? -9.740  -40.520 -16.438 1.00 49.53 ? 382 TRP   A CZ3 1 
ATOM   2687 C CH2 . TRP   A 1 382 ? -9.313  -39.269 -15.982 1.00 49.35 ? 382 TRP   A CH2 1 
ATOM   2688 N N   . ALA   A 1 383 ? -6.994  -47.192 -13.728 1.00 51.82 ? 383 ALA   A N   1 
ATOM   2689 C CA  . ALA   A 1 383 ? -7.505  -48.557 -13.669 1.00 52.29 ? 383 ALA   A CA  1 
ATOM   2690 C C   . ALA   A 1 383 ? -7.410  -49.158 -12.275 1.00 53.30 ? 383 ALA   A C   1 
ATOM   2691 O O   . ALA   A 1 383 ? -8.005  -50.213 -12.031 1.00 54.01 ? 383 ALA   A O   1 
ATOM   2692 C CB  . ALA   A 1 383 ? -6.758  -49.441 -14.671 1.00 48.42 ? 383 ALA   A CB  1 
ATOM   2693 N N   . LYS   A 1 384 ? -6.682  -48.515 -11.360 1.00 51.02 ? 384 LYS   A N   1 
ATOM   2694 C CA  . LYS   A 1 384 ? -6.572  -48.958 -9.977  1.00 51.71 ? 384 LYS   A CA  1 
ATOM   2695 C C   . LYS   A 1 384 ? -7.320  -48.038 -9.017  1.00 52.21 ? 384 LYS   A C   1 
ATOM   2696 O O   . LYS   A 1 384 ? -6.995  -47.989 -7.826  1.00 52.32 ? 384 LYS   A O   1 
ATOM   2697 C CB  . LYS   A 1 384 ? -5.102  -49.069 -9.576  1.00 52.03 ? 384 LYS   A CB  1 
ATOM   2698 C CG  . LYS   A 1 384 ? -4.338  -50.125 -10.356 1.00 54.84 ? 384 LYS   A CG  1 
ATOM   2699 C CD  . LYS   A 1 384 ? -2.841  -50.004 -10.141 1.00 55.74 ? 384 LYS   A CD  1 
ATOM   2700 C CE  . LYS   A 1 384 ? -2.468  -50.191 -8.685  1.00 62.61 ? 384 LYS   A CE  1 
ATOM   2701 N NZ  . LYS   A 1 384 ? -1.029  -49.891 -8.467  1.00 65.98 ? 384 LYS   A NZ  1 
ATOM   2702 N N   . ARG   A 1 385 ? -8.313  -47.305 -9.511  1.00 52.58 ? 385 ARG   A N   1 
ATOM   2703 C CA  . ARG   A 1 385 ? -9.128  -46.421 -8.694  1.00 46.91 ? 385 ARG   A CA  1 
ATOM   2704 C C   . ARG   A 1 385 ? -10.590 -46.835 -8.780  1.00 50.34 ? 385 ARG   A C   1 
ATOM   2705 O O   . ARG   A 1 385 ? -10.988 -47.647 -9.621  1.00 47.21 ? 385 ARG   A O   1 
ATOM   2706 C CB  . ARG   A 1 385 ? -8.990  -44.957 -9.135  1.00 49.63 ? 385 ARG   A CB  1 
ATOM   2707 C CG  . ARG   A 1 385 ? -7.621  -44.335 -8.938  1.00 48.40 ? 385 ARG   A CG  1 
ATOM   2708 C CD  . ARG   A 1 385 ? -7.701  -42.838 -9.208  1.00 47.91 ? 385 ARG   A CD  1 
ATOM   2709 N NE  . ARG   A 1 385 ? -6.398  -42.238 -9.466  1.00 50.75 ? 385 ARG   A NE  1 
ATOM   2710 C CZ  . ARG   A 1 385 ? -6.216  -40.973 -9.823  1.00 47.17 ? 385 ARG   A CZ  1 
ATOM   2711 N NH1 . ARG   A 1 385 ? -7.236  -40.142 -9.966  1.00 48.68 ? 385 ARG   A NH1 1 
ATOM   2712 N NH2 . ARG   A 1 385 ? -4.981  -40.532 -10.046 1.00 46.54 ? 385 ARG   A NH2 1 
ATOM   2713 N N   . SER   A 1 386 ? -11.393 -46.249 -7.895  1.00 50.42 ? 386 SER   A N   1 
ATOM   2714 C CA  . SER   A 1 386 ? -12.840 -46.396 -7.934  1.00 48.76 ? 386 SER   A CA  1 
ATOM   2715 C C   . SER   A 1 386 ? -13.463 -45.100 -7.430  1.00 49.77 ? 386 SER   A C   1 
ATOM   2716 O O   . SER   A 1 386 ? -12.764 -44.176 -7.003  1.00 48.58 ? 386 SER   A O   1 
ATOM   2717 C CB  . SER   A 1 386 ? -13.304 -47.598 -7.108  1.00 51.92 ? 386 SER   A CB  1 
ATOM   2718 O OG  . SER   A 1 386 ? -13.074 -47.387 -5.726  1.00 51.58 ? 386 SER   A OG  1 
ATOM   2719 N N   . LEU   A 1 387 ? -14.791 -45.034 -7.483  1.00 50.90 ? 387 LEU   A N   1 
ATOM   2720 C CA  . LEU   A 1 387 ? -15.520 -43.845 -7.073  1.00 50.64 ? 387 LEU   A CA  1 
ATOM   2721 C C   . LEU   A 1 387 ? -16.703 -44.229 -6.198  1.00 52.68 ? 387 LEU   A C   1 
ATOM   2722 O O   . LEU   A 1 387 ? -17.239 -45.335 -6.297  1.00 53.45 ? 387 LEU   A O   1 
ATOM   2723 C CB  . LEU   A 1 387 ? -16.010 -43.037 -8.283  1.00 50.42 ? 387 LEU   A CB  1 
ATOM   2724 C CG  . LEU   A 1 387 ? -14.993 -42.104 -8.941  1.00 49.87 ? 387 LEU   A CG  1 
ATOM   2725 C CD1 . LEU   A 1 387 ? -15.568 -41.473 -10.194 1.00 46.82 ? 387 LEU   A CD1 1 
ATOM   2726 C CD2 . LEU   A 1 387 ? -14.540 -41.030 -7.962  1.00 46.45 ? 387 LEU   A CD2 1 
ATOM   2727 N N   . SER   A 1 388 ? -17.101 -43.295 -5.339  1.00 49.93 ? 388 SER   A N   1 
ATOM   2728 C CA  . SER   A 1 388 ? -18.267 -43.453 -4.479  1.00 53.00 ? 388 SER   A CA  1 
ATOM   2729 C C   . SER   A 1 388 ? -19.420 -42.665 -5.089  1.00 54.05 ? 388 SER   A C   1 
ATOM   2730 O O   . SER   A 1 388 ? -19.363 -41.433 -5.173  1.00 53.51 ? 388 SER   A O   1 
ATOM   2731 C CB  . SER   A 1 388 ? -17.966 -42.977 -3.059  1.00 53.23 ? 388 SER   A CB  1 
ATOM   2732 O OG  . SER   A 1 388 ? -19.119 -43.058 -2.240  1.00 54.93 ? 388 SER   A OG  1 
ATOM   2733 N N   . ILE   A 1 389 ? -20.460 -43.373 -5.520  1.00 55.01 ? 389 ILE   A N   1 
ATOM   2734 C CA  . ILE   A 1 389 ? -21.653 -42.763 -6.096  1.00 55.58 ? 389 ILE   A CA  1 
ATOM   2735 C C   . ILE   A 1 389 ? -22.846 -43.254 -5.289  1.00 55.35 ? 389 ILE   A C   1 
ATOM   2736 O O   . ILE   A 1 389 ? -23.184 -44.445 -5.331  1.00 54.42 ? 389 ILE   A O   1 
ATOM   2737 C CB  . ILE   A 1 389 ? -21.807 -43.092 -7.587  1.00 56.76 ? 389 ILE   A CB  1 
ATOM   2738 C CG1 . ILE   A 1 389 ? -20.786 -42.301 -8.407  1.00 55.65 ? 389 ILE   A CG1 1 
ATOM   2739 C CG2 . ILE   A 1 389 ? -23.223 -42.796 -8.062  1.00 55.10 ? 389 ILE   A CG2 1 
ATOM   2740 C CD1 . ILE   A 1 389 ? -19.978 -43.142 -9.367  1.00 54.53 ? 389 ILE   A CD1 1 
ATOM   2741 N N   . ASP   A 1 390 ? -23.472 -42.340 -4.543  1.00 54.24 ? 390 ASP   A N   1 
ATOM   2742 C CA  . ASP   A 1 390 ? -24.615 -42.651 -3.682  1.00 56.93 ? 390 ASP   A CA  1 
ATOM   2743 C C   . ASP   A 1 390 ? -24.295 -43.767 -2.691  1.00 56.82 ? 390 ASP   A C   1 
ATOM   2744 O O   . ASP   A 1 390 ? -25.159 -44.581 -2.353  1.00 56.51 ? 390 ASP   A O   1 
ATOM   2745 C CB  . ASP   A 1 390 ? -25.855 -43.007 -4.509  1.00 56.33 ? 390 ASP   A CB  1 
ATOM   2746 C CG  . ASP   A 1 390 ? -26.450 -41.804 -5.210  1.00 58.53 ? 390 ASP   A CG  1 
ATOM   2747 O OD1 . ASP   A 1 390 ? -26.340 -40.686 -4.666  1.00 60.57 ? 390 ASP   A OD1 1 
ATOM   2748 O OD2 . ASP   A 1 390 ? -27.027 -41.975 -6.303  1.00 55.11 ? 390 ASP   A OD2 1 
ATOM   2749 N N   . GLY   A 1 391 ? -23.055 -43.809 -2.208  1.00 55.02 ? 391 GLY   A N   1 
ATOM   2750 C CA  . GLY   A 1 391 ? -22.627 -44.847 -1.296  1.00 53.63 ? 391 GLY   A CA  1 
ATOM   2751 C C   . GLY   A 1 391 ? -22.193 -46.139 -1.951  1.00 57.77 ? 391 GLY   A C   1 
ATOM   2752 O O   . GLY   A 1 391 ? -21.736 -47.049 -1.246  1.00 63.20 ? 391 GLY   A O   1 
ATOM   2753 N N   . GLY   A 1 392 ? -22.321 -46.252 -3.269  1.00 54.18 ? 392 GLY   A N   1 
ATOM   2754 C CA  . GLY   A 1 392 ? -21.891 -47.430 -3.993  1.00 55.75 ? 392 GLY   A CA  1 
ATOM   2755 C C   . GLY   A 1 392 ? -20.580 -47.193 -4.719  1.00 54.12 ? 392 GLY   A C   1 
ATOM   2756 O O   . GLY   A 1 392 ? -20.256 -46.071 -5.099  1.00 55.71 ? 392 GLY   A O   1 
ATOM   2757 N N   . ILE   A 1 393 ? -19.830 -48.271 -4.907  1.00 51.31 ? 393 ILE   A N   1 
ATOM   2758 C CA  . ILE   A 1 393 ? -18.527 -48.222 -5.561  1.00 51.31 ? 393 ILE   A CA  1 
ATOM   2759 C C   . ILE   A 1 393 ? -18.710 -48.476 -7.050  1.00 57.85 ? 393 ILE   A C   1 
ATOM   2760 O O   . ILE   A 1 393 ? -19.441 -49.387 -7.455  1.00 59.02 ? 393 ILE   A O   1 
ATOM   2761 C CB  . ILE   A 1 393 ? -17.566 -49.245 -4.929  1.00 50.08 ? 393 ILE   A CB  1 
ATOM   2762 C CG1 . ILE   A 1 393 ? -17.520 -49.056 -3.410  1.00 54.02 ? 393 ILE   A CG1 1 
ATOM   2763 C CG2 . ILE   A 1 393 ? -16.178 -49.107 -5.520  1.00 52.36 ? 393 ILE   A CG2 1 
ATOM   2764 C CD1 . ILE   A 1 393 ? -16.595 -50.016 -2.699  1.00 54.02 ? 393 ILE   A CD1 1 
ATOM   2765 N N   . ALA   A 1 394 ? -18.046 -47.667 -7.867  1.00 54.66 ? 394 ALA   A N   1 
ATOM   2766 C CA  . ALA   A 1 394 ? -18.159 -47.709 -9.316  1.00 50.71 ? 394 ALA   A CA  1 
ATOM   2767 C C   . ALA   A 1 394 ? -16.781 -47.524 -9.929  1.00 52.19 ? 394 ALA   A C   1 
ATOM   2768 O O   . ALA   A 1 394 ? -15.863 -47.023 -9.269  1.00 51.31 ? 394 ALA   A O   1 
ATOM   2769 C CB  . ALA   A 1 394 ? -19.116 -46.625 -9.832  1.00 50.28 ? 394 ALA   A CB  1 
ATOM   2770 N N   . PRO   A 1 395 ? -16.595 -47.936 -11.186 1.00 48.36 ? 395 PRO   A N   1 
ATOM   2771 C CA  . PRO   A 1 395 ? -15.311 -47.697 -11.857 1.00 49.88 ? 395 PRO   A CA  1 
ATOM   2772 C C   . PRO   A 1 395 ? -14.991 -46.213 -11.949 1.00 51.02 ? 395 PRO   A C   1 
ATOM   2773 O O   . PRO   A 1 395 ? -15.882 -45.364 -12.033 1.00 53.60 ? 395 PRO   A O   1 
ATOM   2774 C CB  . PRO   A 1 395 ? -15.517 -48.309 -13.248 1.00 47.53 ? 395 PRO   A CB  1 
ATOM   2775 C CG  . PRO   A 1 395 ? -16.571 -49.339 -13.051 1.00 50.02 ? 395 PRO   A CG  1 
ATOM   2776 C CD  . PRO   A 1 395 ? -17.485 -48.793 -11.991 1.00 46.94 ? 395 PRO   A CD  1 
ATOM   2777 N N   . PHE   A 1 396 ? -13.693 -45.905 -11.936 1.00 50.94 ? 396 PHE   A N   1 
ATOM   2778 C CA  . PHE   A 1 396 ? -13.252 -44.516 -12.019 1.00 49.96 ? 396 PHE   A CA  1 
ATOM   2779 C C   . PHE   A 1 396 ? -13.176 -44.045 -13.467 1.00 48.64 ? 396 PHE   A C   1 
ATOM   2780 O O   . PHE   A 1 396 ? -13.830 -43.068 -13.849 1.00 46.41 ? 396 PHE   A O   1 
ATOM   2781 C CB  . PHE   A 1 396 ? -11.893 -44.355 -11.328 1.00 48.67 ? 396 PHE   A CB  1 
ATOM   2782 C CG  . PHE   A 1 396 ? -11.454 -42.924 -11.168 1.00 50.23 ? 396 PHE   A CG  1 
ATOM   2783 C CD1 . PHE   A 1 396 ? -10.829 -42.253 -12.207 1.00 48.90 ? 396 PHE   A CD1 1 
ATOM   2784 C CD2 . PHE   A 1 396 ? -11.658 -42.255 -9.973  1.00 49.05 ? 396 PHE   A CD2 1 
ATOM   2785 C CE1 . PHE   A 1 396 ? -10.428 -40.938 -12.061 1.00 49.04 ? 396 PHE   A CE1 1 
ATOM   2786 C CE2 . PHE   A 1 396 ? -11.256 -40.939 -9.820  1.00 46.49 ? 396 PHE   A CE2 1 
ATOM   2787 C CZ  . PHE   A 1 396 ? -10.642 -40.280 -10.865 1.00 47.05 ? 396 PHE   A CZ  1 
ATOM   2788 N N   . ALA   A 1 397 ? -12.380 -44.737 -14.286 1.00 48.41 ? 397 ALA   A N   1 
ATOM   2789 C CA  . ALA   A 1 397 ? -12.153 -44.320 -15.666 1.00 45.86 ? 397 ALA   A CA  1 
ATOM   2790 C C   . ALA   A 1 397 ? -13.422 -44.347 -16.509 1.00 46.43 ? 397 ALA   A C   1 
ATOM   2791 O O   . ALA   A 1 397 ? -13.477 -43.673 -17.544 1.00 46.37 ? 397 ALA   A O   1 
ATOM   2792 C CB  . ALA   A 1 397 ? -11.087 -45.207 -16.314 1.00 41.87 ? 397 ALA   A CB  1 
ATOM   2793 N N   . ALA   A 1 398 ? -14.441 -45.103 -16.094 1.00 46.52 ? 398 ALA   A N   1 
ATOM   2794 C CA  . ALA   A 1 398 ? -15.687 -45.149 -16.852 1.00 46.95 ? 398 ALA   A CA  1 
ATOM   2795 C C   . ALA   A 1 398 ? -16.363 -43.787 -16.939 1.00 48.04 ? 398 ALA   A C   1 
ATOM   2796 O O   . ALA   A 1 398 ? -17.149 -43.557 -17.864 1.00 52.14 ? 398 ALA   A O   1 
ATOM   2797 C CB  . ALA   A 1 398 ? -16.645 -46.167 -16.232 1.00 47.61 ? 398 ALA   A CB  1 
ATOM   2798 N N   . GLN   A 1 399 ? -16.062 -42.875 -16.009 1.00 44.32 ? 399 GLN   A N   1 
ATOM   2799 C CA  . GLN   A 1 399 ? -16.678 -41.554 -15.998 1.00 44.89 ? 399 GLN   A CA  1 
ATOM   2800 C C   . GLN   A 1 399 ? -16.247 -40.686 -17.172 1.00 43.14 ? 399 GLN   A C   1 
ATOM   2801 O O   . GLN   A 1 399 ? -16.809 -39.600 -17.352 1.00 43.28 ? 399 GLN   A O   1 
ATOM   2802 C CB  . GLN   A 1 399 ? -16.354 -40.839 -14.687 1.00 45.31 ? 399 GLN   A CB  1 
ATOM   2803 C CG  . GLN   A 1 399 ? -16.922 -41.520 -13.462 1.00 42.27 ? 399 GLN   A CG  1 
ATOM   2804 C CD  . GLN   A 1 399 ? -18.421 -41.345 -13.341 1.00 42.27 ? 399 GLN   A CD  1 
ATOM   2805 O OE1 . GLN   A 1 399 ? -18.962 -40.292 -13.674 1.00 43.88 ? 399 GLN   A OE1 1 
ATOM   2806 N NE2 . GLN   A 1 399 ? -19.102 -42.384 -12.872 1.00 42.00 ? 399 GLN   A NE2 1 
ATOM   2807 N N   . LEU   A 1 400 ? -15.270 -41.131 -17.966 1.00 44.05 ? 400 LEU   A N   1 
ATOM   2808 C CA  . LEU   A 1 400 ? -14.859 -40.384 -19.148 1.00 45.33 ? 400 LEU   A CA  1 
ATOM   2809 C C   . LEU   A 1 400 ? -15.976 -40.282 -20.180 1.00 42.04 ? 400 LEU   A C   1 
ATOM   2810 O O   . LEU   A 1 400 ? -15.910 -39.420 -21.064 1.00 42.40 ? 400 LEU   A O   1 
ATOM   2811 C CB  . LEU   A 1 400 ? -13.624 -41.038 -19.777 1.00 45.44 ? 400 LEU   A CB  1 
ATOM   2812 C CG  . LEU   A 1 400 ? -12.269 -40.784 -19.119 1.00 47.34 ? 400 LEU   A CG  1 
ATOM   2813 C CD1 . LEU   A 1 400 ? -11.237 -41.787 -19.605 1.00 49.53 ? 400 LEU   A CD1 1 
ATOM   2814 C CD2 . LEU   A 1 400 ? -11.806 -39.365 -19.413 1.00 44.37 ? 400 LEU   A CD2 1 
ATOM   2815 N N   . GLY   A 1 401 ? -16.996 -41.143 -20.089 1.00 44.35 ? 401 GLY   A N   1 
ATOM   2816 C CA  . GLY   A 1 401 ? -18.083 -41.103 -21.053 1.00 43.56 ? 401 GLY   A CA  1 
ATOM   2817 C C   . GLY   A 1 401 ? -18.869 -39.808 -21.026 1.00 43.06 ? 401 GLY   A C   1 
ATOM   2818 O O   . GLY   A 1 401 ? -19.347 -39.348 -22.069 1.00 44.75 ? 401 GLY   A O   1 
ATOM   2819 N N   . TRP   A 1 402 ? -19.026 -39.209 -19.841 1.00 43.25 ? 402 TRP   A N   1 
ATOM   2820 C CA  . TRP   A 1 402 ? -19.713 -37.924 -19.758 1.00 43.96 ? 402 TRP   A CA  1 
ATOM   2821 C C   . TRP   A 1 402 ? -18.980 -36.844 -20.538 1.00 42.07 ? 402 TRP   A C   1 
ATOM   2822 O O   . TRP   A 1 402 ? -19.604 -35.882 -21.005 1.00 38.84 ? 402 TRP   A O   1 
ATOM   2823 C CB  . TRP   A 1 402 ? -19.862 -37.494 -18.302 1.00 42.00 ? 402 TRP   A CB  1 
ATOM   2824 C CG  . TRP   A 1 402 ? -20.697 -38.409 -17.476 1.00 46.55 ? 402 TRP   A CG  1 
ATOM   2825 C CD1 . TRP   A 1 402 ? -20.276 -39.187 -16.439 1.00 45.05 ? 402 TRP   A CD1 1 
ATOM   2826 C CD2 . TRP   A 1 402 ? -22.102 -38.649 -17.617 1.00 45.87 ? 402 TRP   A CD2 1 
ATOM   2827 N NE1 . TRP   A 1 402 ? -21.335 -39.894 -15.921 1.00 47.49 ? 402 TRP   A NE1 1 
ATOM   2828 C CE2 . TRP   A 1 402 ? -22.466 -39.583 -16.630 1.00 48.36 ? 402 TRP   A CE2 1 
ATOM   2829 C CE3 . TRP   A 1 402 ? -23.086 -38.163 -18.481 1.00 43.42 ? 402 TRP   A CE3 1 
ATOM   2830 C CZ2 . TRP   A 1 402 ? -23.773 -40.042 -16.482 1.00 48.08 ? 402 TRP   A CZ2 1 
ATOM   2831 C CZ3 . TRP   A 1 402 ? -24.384 -38.620 -18.333 1.00 45.76 ? 402 TRP   A CZ3 1 
ATOM   2832 C CH2 . TRP   A 1 402 ? -24.715 -39.550 -17.342 1.00 45.87 ? 402 TRP   A CH2 1 
ATOM   2833 N N   . ILE   A 1 403 ? -17.662 -36.985 -20.690 1.00 42.14 ? 403 ILE   A N   1 
ATOM   2834 C CA  . ILE   A 1 403 ? -16.839 -35.952 -21.308 1.00 41.96 ? 403 ILE   A CA  1 
ATOM   2835 C C   . ILE   A 1 403 ? -16.512 -36.252 -22.768 1.00 39.30 ? 403 ILE   A C   1 
ATOM   2836 O O   . ILE   A 1 403 ? -16.025 -35.357 -23.481 1.00 38.67 ? 403 ILE   A O   1 
ATOM   2837 C CB  . ILE   A 1 403 ? -15.553 -35.742 -20.474 1.00 40.50 ? 403 ILE   A CB  1 
ATOM   2838 C CG1 . ILE   A 1 403 ? -15.397 -34.268 -20.087 1.00 41.95 ? 403 ILE   A CG1 1 
ATOM   2839 C CG2 . ILE   A 1 403 ? -14.311 -36.275 -21.188 1.00 43.39 ? 403 ILE   A CG2 1 
ATOM   2840 C CD1 . ILE   A 1 403 ? -16.526 -33.733 -19.229 1.00 45.55 ? 403 ILE   A CD1 1 
ATOM   2841 N N   . SER   A 1 404 ? -16.826 -37.457 -23.251 1.00 40.93 ? 404 SER   A N   1 
ATOM   2842 C CA  . SER   A 1 404 ? -16.339 -37.899 -24.555 1.00 41.42 ? 404 SER   A CA  1 
ATOM   2843 C C   . SER   A 1 404 ? -17.026 -37.171 -25.707 1.00 40.92 ? 404 SER   A C   1 
ATOM   2844 O O   . SER   A 1 404 ? -16.401 -36.922 -26.743 1.00 41.05 ? 404 SER   A O   1 
ATOM   2845 C CB  . SER   A 1 404 ? -16.540 -39.407 -24.695 1.00 41.33 ? 404 SER   A CB  1 
ATOM   2846 O OG  . SER   A 1 404 ? -17.893 -39.761 -24.466 1.00 46.10 ? 404 SER   A OG  1 
ATOM   2847 N N   . MET   A 1 405 ? -18.308 -36.829 -25.554 1.00 39.98 ? 405 MET   A N   1 
ATOM   2848 C CA  . MET   A 1 405 ? -19.085 -36.314 -26.681 1.00 38.23 ? 405 MET   A CA  1 
ATOM   2849 C C   . MET   A 1 405 ? -18.469 -35.040 -27.250 1.00 39.81 ? 405 MET   A C   1 
ATOM   2850 O O   . MET   A 1 405 ? -18.211 -34.945 -28.454 1.00 38.75 ? 405 MET   A O   1 
ATOM   2851 C CB  . MET   A 1 405 ? -20.534 -36.067 -26.251 1.00 39.42 ? 405 MET   A CB  1 
ATOM   2852 C CG  . MET   A 1 405 ? -21.308 -37.327 -25.903 1.00 42.82 ? 405 MET   A CG  1 
ATOM   2853 S SD  . MET   A 1 405 ? -21.152 -37.820 -24.174 1.00 47.58 ? 405 MET   A SD  1 
ATOM   2854 C CE  . MET   A 1 405 ? -22.308 -36.696 -23.394 1.00 46.67 ? 405 MET   A CE  1 
ATOM   2855 N N   . ALA   A 1 406 ? -18.222 -34.050 -26.393 1.00 37.24 ? 406 ALA   A N   1 
ATOM   2856 C CA  . ALA   A 1 406 ? -17.694 -32.773 -26.864 1.00 39.17 ? 406 ALA   A CA  1 
ATOM   2857 C C   . ALA   A 1 406 ? -16.257 -32.905 -27.351 1.00 38.61 ? 406 ALA   A C   1 
ATOM   2858 O O   . ALA   A 1 406 ? -15.868 -32.262 -28.333 1.00 38.39 ? 406 ALA   A O   1 
ATOM   2859 C CB  . ALA   A 1 406 ? -17.784 -31.729 -25.752 1.00 39.06 ? 406 ALA   A CB  1 
ATOM   2860 N N   . THR   A 1 407 ? -15.455 -33.729 -26.676 1.00 36.45 ? 407 THR   A N   1 
ATOM   2861 C CA  . THR   A 1 407 ? -14.058 -33.885 -27.064 1.00 39.70 ? 407 THR   A CA  1 
ATOM   2862 C C   . THR   A 1 407 ? -13.934 -34.643 -28.381 1.00 39.24 ? 407 THR   A C   1 
ATOM   2863 O O   . THR   A 1 407 ? -13.215 -34.214 -29.291 1.00 38.22 ? 407 THR   A O   1 
ATOM   2864 C CB  . THR   A 1 407 ? -13.284 -34.601 -25.957 1.00 41.18 ? 407 THR   A CB  1 
ATOM   2865 O OG1 . THR   A 1 407 ? -13.316 -33.812 -24.760 1.00 43.21 ? 407 THR   A OG1 1 
ATOM   2866 C CG2 . THR   A 1 407 ? -11.841 -34.817 -26.374 1.00 41.15 ? 407 THR   A CG2 1 
ATOM   2867 N N   . TYR   A 1 408 ? -14.634 -35.772 -28.504 1.00 41.21 ? 408 TYR   A N   1 
ATOM   2868 C CA  . TYR   A 1 408 ? -14.528 -36.572 -29.720 1.00 40.40 ? 408 TYR   A CA  1 
ATOM   2869 C C   . TYR   A 1 408 ? -15.235 -35.891 -30.887 1.00 40.95 ? 408 TYR   A C   1 
ATOM   2870 O O   . TYR   A 1 408 ? -14.674 -35.771 -31.981 1.00 38.81 ? 408 TYR   A O   1 
ATOM   2871 C CB  . TYR   A 1 408 ? -15.093 -37.973 -29.480 1.00 38.63 ? 408 TYR   A CB  1 
ATOM   2872 C CG  . TYR   A 1 408 ? -14.734 -38.972 -30.556 1.00 39.64 ? 408 TYR   A CG  1 
ATOM   2873 C CD1 . TYR   A 1 408 ? -13.424 -39.398 -30.724 1.00 38.82 ? 408 TYR   A CD1 1 
ATOM   2874 C CD2 . TYR   A 1 408 ? -15.706 -39.493 -31.399 1.00 41.14 ? 408 TYR   A CD2 1 
ATOM   2875 C CE1 . TYR   A 1 408 ? -13.088 -40.313 -31.703 1.00 43.41 ? 408 TYR   A CE1 1 
ATOM   2876 C CE2 . TYR   A 1 408 ? -15.380 -40.408 -32.381 1.00 39.39 ? 408 TYR   A CE2 1 
ATOM   2877 C CZ  . TYR   A 1 408 ? -14.070 -40.815 -32.529 1.00 40.58 ? 408 TYR   A CZ  1 
ATOM   2878 O OH  . TYR   A 1 408 ? -13.749 -41.726 -33.511 1.00 38.16 ? 408 TYR   A OH  1 
ATOM   2879 N N   . GLY   A 1 409 ? -16.470 -35.432 -30.671 1.00 40.73 ? 409 GLY   A N   1 
ATOM   2880 C CA  . GLY   A 1 409 ? -17.193 -34.731 -31.718 1.00 39.27 ? 409 GLY   A CA  1 
ATOM   2881 C C   . GLY   A 1 409 ? -16.644 -33.357 -32.032 1.00 40.63 ? 409 GLY   A C   1 
ATOM   2882 O O   . GLY   A 1 409 ? -16.945 -32.811 -33.098 1.00 44.98 ? 409 GLY   A O   1 
ATOM   2883 N N   . GLY   A 1 410 ? -15.842 -32.790 -31.134 1.00 38.50 ? 410 GLY   A N   1 
ATOM   2884 C CA  . GLY   A 1 410 ? -15.274 -31.475 -31.327 1.00 39.46 ? 410 GLY   A CA  1 
ATOM   2885 C C   . GLY   A 1 410 ? -16.156 -30.320 -30.908 1.00 38.89 ? 410 GLY   A C   1 
ATOM   2886 O O   . GLY   A 1 410 ? -15.726 -29.166 -31.016 1.00 39.63 ? 410 GLY   A O   1 
ATOM   2887 N N   . MET   A 1 411 ? -17.363 -30.589 -30.422 1.00 39.57 ? 411 MET   A N   1 
ATOM   2888 C CA  . MET   A 1 411 ? -18.289 -29.520 -30.094 1.00 40.01 ? 411 MET   A CA  1 
ATOM   2889 C C   . MET   A 1 411 ? -17.784 -28.716 -28.897 1.00 37.13 ? 411 MET   A C   1 
ATOM   2890 O O   . MET   A 1 411 ? -17.006 -29.217 -28.082 1.00 40.19 ? 411 MET   A O   1 
ATOM   2891 C CB  . MET   A 1 411 ? -19.680 -30.086 -29.802 1.00 39.64 ? 411 MET   A CB  1 
ATOM   2892 C CG  . MET   A 1 411 ? -20.375 -30.709 -31.006 1.00 39.04 ? 411 MET   A CG  1 
ATOM   2893 S SD  . MET   A 1 411 ? -20.135 -32.490 -31.125 1.00 42.00 ? 411 MET   A SD  1 
ATOM   2894 C CE  . MET   A 1 411 ? -20.909 -33.035 -29.604 1.00 36.20 ? 411 MET   A CE  1 
ATOM   2895 N N   . PRO   A 1 412 ? -18.188 -27.453 -28.786 1.00 38.76 ? 412 PRO   A N   1 
ATOM   2896 C CA  . PRO   A 1 412 ? -17.910 -26.701 -27.561 1.00 38.29 ? 412 PRO   A CA  1 
ATOM   2897 C C   . PRO   A 1 412 ? -18.806 -27.181 -26.432 1.00 39.40 ? 412 PRO   A C   1 
ATOM   2898 O O   . PRO   A 1 412 ? -19.913 -27.677 -26.657 1.00 38.48 ? 412 PRO   A O   1 
ATOM   2899 C CB  . PRO   A 1 412 ? -18.226 -25.252 -27.950 1.00 36.34 ? 412 PRO   A CB  1 
ATOM   2900 C CG  . PRO   A 1 412 ? -19.238 -25.386 -29.039 1.00 38.68 ? 412 PRO   A CG  1 
ATOM   2901 C CD  . PRO   A 1 412 ? -18.864 -26.626 -29.800 1.00 39.18 ? 412 PRO   A CD  1 
ATOM   2902 N N   . ALA   A 1 413 ? -18.307 -27.044 -25.205 1.00 36.39 ? 413 ALA   A N   1 
ATOM   2903 C CA  . ALA   A 1 413 ? -19.051 -27.505 -24.037 1.00 38.64 ? 413 ALA   A CA  1 
ATOM   2904 C C   . ALA   A 1 413 ? -18.787 -26.567 -22.871 1.00 39.80 ? 413 ALA   A C   1 
ATOM   2905 O O   . ALA   A 1 413 ? -17.633 -26.369 -22.478 1.00 37.46 ? 413 ALA   A O   1 
ATOM   2906 C CB  . ALA   A 1 413 ? -18.664 -28.938 -23.673 1.00 38.10 ? 413 ALA   A CB  1 
ATOM   2907 N N   . LEU   A 1 414 ? -19.851 -25.999 -22.316 1.00 38.52 ? 414 LEU   A N   1 
ATOM   2908 C CA  . LEU   A 1 414 ? -19.737 -25.115 -21.166 1.00 39.27 ? 414 LEU   A CA  1 
ATOM   2909 C C   . LEU   A 1 414 ? -19.953 -25.900 -19.879 1.00 37.61 ? 414 LEU   A C   1 
ATOM   2910 O O   . LEU   A 1 414 ? -20.779 -26.816 -19.827 1.00 40.03 ? 414 LEU   A O   1 
ATOM   2911 C CB  . LEU   A 1 414 ? -20.750 -23.973 -21.254 1.00 41.23 ? 414 LEU   A CB  1 
ATOM   2912 C CG  . LEU   A 1 414 ? -20.714 -22.953 -20.117 1.00 39.68 ? 414 LEU   A CG  1 
ATOM   2913 C CD1 . LEU   A 1 414 ? -19.407 -22.171 -20.142 1.00 40.04 ? 414 LEU   A CD1 1 
ATOM   2914 C CD2 . LEU   A 1 414 ? -21.901 -22.021 -20.193 1.00 39.77 ? 414 LEU   A CD2 1 
ATOM   2915 N N   . SER   A 1 415 ? -19.199 -25.540 -18.844 1.00 39.98 ? 415 SER   A N   1 
ATOM   2916 C CA  . SER   A 1 415 ? -19.372 -26.089 -17.503 1.00 38.49 ? 415 SER   A CA  1 
ATOM   2917 C C   . SER   A 1 415 ? -19.719 -24.936 -16.570 1.00 37.38 ? 415 SER   A C   1 
ATOM   2918 O O   . SER   A 1 415 ? -18.854 -24.116 -16.243 1.00 39.88 ? 415 SER   A O   1 
ATOM   2919 C CB  . SER   A 1 415 ? -18.115 -26.823 -17.037 1.00 39.25 ? 415 SER   A CB  1 
ATOM   2920 O OG  . SER   A 1 415 ? -18.309 -27.400 -15.755 1.00 39.90 ? 415 SER   A OG  1 
ATOM   2921 N N   . MET   A 1 416 ? -20.980 -24.871 -16.147 1.00 39.58 ? 416 MET   A N   1 
ATOM   2922 C CA  . MET   A 1 416 ? -21.474 -23.753 -15.360 1.00 42.45 ? 416 MET   A CA  1 
ATOM   2923 C C   . MET   A 1 416 ? -22.021 -24.227 -14.019 1.00 41.89 ? 416 MET   A C   1 
ATOM   2924 O O   . MET   A 1 416 ? -22.561 -25.334 -13.918 1.00 42.06 ? 416 MET   A O   1 
ATOM   2925 C CB  . MET   A 1 416 ? -22.567 -22.984 -16.113 1.00 38.17 ? 416 MET   A CB  1 
ATOM   2926 C CG  . MET   A 1 416 ? -23.765 -23.829 -16.512 1.00 38.01 ? 416 MET   A CG  1 
ATOM   2927 S SD  . MET   A 1 416 ? -25.214 -22.826 -16.886 1.00 47.04 ? 416 MET   A SD  1 
ATOM   2928 C CE  . MET   A 1 416 ? -25.516 -22.042 -15.302 1.00 40.53 ? 416 MET   A CE  1 
ATOM   2929 N N   . PRO   A 1 417 ? -21.902 -23.404 -12.977 1.00 41.05 ? 417 PRO   A N   1 
ATOM   2930 C CA  . PRO   A 1 417 ? -22.371 -23.816 -11.647 1.00 43.51 ? 417 PRO   A CA  1 
ATOM   2931 C C   . PRO   A 1 417 ? -23.882 -24.003 -11.609 1.00 44.61 ? 417 PRO   A C   1 
ATOM   2932 O O   . PRO   A 1 417 ? -24.641 -23.163 -12.095 1.00 44.09 ? 417 PRO   A O   1 
ATOM   2933 C CB  . PRO   A 1 417 ? -21.929 -22.661 -10.740 1.00 38.90 ? 417 PRO   A CB  1 
ATOM   2934 C CG  . PRO   A 1 417 ? -20.797 -22.021 -11.478 1.00 42.34 ? 417 PRO   A CG  1 
ATOM   2935 C CD  . PRO   A 1 417 ? -21.156 -22.137 -12.925 1.00 39.36 ? 417 PRO   A CD  1 
ATOM   2936 N N   . LEU   A 1 418 ? -24.310 -25.120 -11.024 1.00 43.11 ? 418 LEU   A N   1 
ATOM   2937 C CA  . LEU   A 1 418 ? -25.710 -25.395 -10.725 1.00 44.43 ? 418 LEU   A CA  1 
ATOM   2938 C C   . LEU   A 1 418 ? -26.032 -25.227 -9.249  1.00 51.98 ? 418 LEU   A C   1 
ATOM   2939 O O   . LEU   A 1 418 ? -26.957 -24.491 -8.893  1.00 51.97 ? 418 LEU   A O   1 
ATOM   2940 C CB  . LEU   A 1 418 ? -26.078 -26.820 -11.166 1.00 45.41 ? 418 LEU   A CB  1 
ATOM   2941 C CG  . LEU   A 1 418 ? -26.584 -27.036 -12.589 1.00 47.73 ? 418 LEU   A CG  1 
ATOM   2942 C CD1 . LEU   A 1 418 ? -26.910 -28.502 -12.808 1.00 45.27 ? 418 LEU   A CD1 1 
ATOM   2943 C CD2 . LEU   A 1 418 ? -27.799 -26.174 -12.840 1.00 47.50 ? 418 LEU   A CD2 1 
ATOM   2944 N N   . GLY   A 1 419 ? -25.283 -25.900 -8.381  1.00 48.33 ? 419 GLY   A N   1 
ATOM   2945 C CA  . GLY   A 1 419 ? -25.502 -25.850 -6.951  1.00 48.29 ? 419 GLY   A CA  1 
ATOM   2946 C C   . GLY   A 1 419 ? -24.486 -26.698 -6.218  1.00 48.65 ? 419 GLY   A C   1 
ATOM   2947 O O   . GLY   A 1 419 ? -23.334 -26.792 -6.648  1.00 48.00 ? 419 GLY   A O   1 
ATOM   2948 N N   . ALA   A 1 420 ? -24.892 -27.332 -5.121  1.00 50.16 ? 420 ALA   A N   1 
ATOM   2949 C CA  . ALA   A 1 420 ? -23.998 -28.197 -4.368  1.00 50.29 ? 420 ALA   A CA  1 
ATOM   2950 C C   . ALA   A 1 420 ? -24.772 -29.405 -3.866  1.00 49.30 ? 420 ALA   A C   1 
ATOM   2951 O O   . ALA   A 1 420 ? -25.987 -29.342 -3.665  1.00 50.37 ? 420 ALA   A O   1 
ATOM   2952 C CB  . ALA   A 1 420 ? -23.345 -27.455 -3.192  1.00 49.41 ? 420 ALA   A CB  1 
ATOM   2953 N N   . ASP   A 1 421 ? -24.059 -30.509 -3.663  1.00 47.63 ? 421 ASP   A N   1 
ATOM   2954 C CA  . ASP   A 1 421 ? -24.705 -31.701 -3.142  1.00 51.87 ? 421 ASP   A CA  1 
ATOM   2955 C C   . ASP   A 1 421 ? -24.860 -31.587 -1.625  1.00 50.42 ? 421 ASP   A C   1 
ATOM   2956 O O   . ASP   A 1 421 ? -24.570 -30.550 -1.018  1.00 50.33 ? 421 ASP   A O   1 
ATOM   2957 C CB  . ASP   A 1 421 ? -23.934 -32.956 -3.555  1.00 49.08 ? 421 ASP   A CB  1 
ATOM   2958 C CG  . ASP   A 1 421 ? -22.541 -33.034 -2.947  1.00 52.84 ? 421 ASP   A CG  1 
ATOM   2959 O OD1 . ASP   A 1 421 ? -22.128 -32.108 -2.217  1.00 52.14 ? 421 ASP   A OD1 1 
ATOM   2960 O OD2 . ASP   A 1 421 ? -21.853 -34.043 -3.205  1.00 52.41 ? 421 ASP   A OD2 1 
ATOM   2961 N N   . GLY   A 1 422 ? -25.322 -32.677 -1.005  1.00 52.53 ? 422 GLY   A N   1 
ATOM   2962 C CA  . GLY   A 1 422 ? -25.588 -32.658 0.424   1.00 53.15 ? 422 GLY   A CA  1 
ATOM   2963 C C   . GLY   A 1 422 ? -24.371 -32.340 1.271   1.00 53.86 ? 422 GLY   A C   1 
ATOM   2964 O O   . GLY   A 1 422 ? -24.504 -31.821 2.382   1.00 52.09 ? 422 GLY   A O   1 
ATOM   2965 N N   . ASN   A 1 423 ? -23.177 -32.640 0.767   1.00 55.73 ? 423 ASN   A N   1 
ATOM   2966 C CA  . ASN   A 1 423 ? -21.939 -32.374 1.486   1.00 52.48 ? 423 ASN   A CA  1 
ATOM   2967 C C   . ASN   A 1 423 ? -21.318 -31.029 1.120   1.00 52.84 ? 423 ASN   A C   1 
ATOM   2968 O O   . ASN   A 1 423 ? -20.167 -30.773 1.488   1.00 54.08 ? 423 ASN   A O   1 
ATOM   2969 C CB  . ASN   A 1 423 ? -20.932 -33.501 1.234   1.00 52.90 ? 423 ASN   A CB  1 
ATOM   2970 C CG  . ASN   A 1 423 ? -21.434 -34.852 1.714   1.00 56.60 ? 423 ASN   A CG  1 
ATOM   2971 O OD1 . ASN   A 1 423 ? -22.022 -34.966 2.789   1.00 61.14 ? 423 ASN   A OD1 1 
ATOM   2972 N ND2 . ASN   A 1 423 ? -21.202 -35.885 0.912   1.00 56.00 ? 423 ASN   A ND2 1 
ATOM   2973 N N   . GLY   A 1 424 ? -22.048 -30.168 0.412   1.00 53.69 ? 424 GLY   A N   1 
ATOM   2974 C CA  . GLY   A 1 424 ? -21.538 -28.863 0.044   1.00 53.25 ? 424 GLY   A CA  1 
ATOM   2975 C C   . GLY   A 1 424 ? -20.583 -28.851 -1.126  1.00 51.83 ? 424 GLY   A C   1 
ATOM   2976 O O   . GLY   A 1 424 ? -19.926 -27.830 -1.359  1.00 52.03 ? 424 GLY   A O   1 
ATOM   2977 N N   . LEU   A 1 425 ? -20.491 -29.940 -1.869  1.00 49.38 ? 425 LEU   A N   1 
ATOM   2978 C CA  . LEU   A 1 425 ? -19.572 -30.014 -2.997  1.00 52.13 ? 425 LEU   A CA  1 
ATOM   2979 C C   . LEU   A 1 425 ? -20.278 -29.570 -4.273  1.00 49.18 ? 425 LEU   A C   1 
ATOM   2980 O O   . LEU   A 1 425 ? -21.382 -30.050 -4.561  1.00 47.54 ? 425 LEU   A O   1 
ATOM   2981 C CB  . LEU   A 1 425 ? -19.036 -31.427 -3.157  1.00 51.65 ? 425 LEU   A CB  1 
ATOM   2982 C CG  . LEU   A 1 425 ? -18.197 -31.915 -1.975  1.00 51.22 ? 425 LEU   A CG  1 
ATOM   2983 C CD1 . LEU   A 1 425 ? -17.902 -33.401 -2.101  1.00 49.63 ? 425 LEU   A CD1 1 
ATOM   2984 C CD2 . LEU   A 1 425 ? -16.906 -31.113 -1.870  1.00 48.29 ? 425 LEU   A CD2 1 
ATOM   2985 N N   . PRO   A 1 426 ? -19.677 -28.665 -5.047  1.00 49.19 ? 426 PRO   A N   1 
ATOM   2986 C CA  . PRO   A 1 426 ? -20.401 -28.044 -6.163  1.00 45.93 ? 426 PRO   A CA  1 
ATOM   2987 C C   . PRO   A 1 426 ? -20.797 -29.048 -7.236  1.00 42.26 ? 426 PRO   A C   1 
ATOM   2988 O O   . PRO   A 1 426 ? -20.065 -29.995 -7.531  1.00 44.12 ? 426 PRO   A O   1 
ATOM   2989 C CB  . PRO   A 1 426 ? -19.398 -27.016 -6.701  1.00 44.01 ? 426 PRO   A CB  1 
ATOM   2990 C CG  . PRO   A 1 426 ? -18.480 -26.740 -5.557  1.00 45.88 ? 426 PRO   A CG  1 
ATOM   2991 C CD  . PRO   A 1 426 ? -18.356 -28.047 -4.833  1.00 48.42 ? 426 PRO   A CD  1 
ATOM   2992 N N   . ILE   A 1 427 ? -21.979 -28.829 -7.809  1.00 44.66 ? 427 ILE   A N   1 
ATOM   2993 C CA  . ILE   A 1 427 ? -22.465 -29.570 -8.966  1.00 45.10 ? 427 ILE   A CA  1 
ATOM   2994 C C   . ILE   A 1 427 ? -22.596 -28.591 -10.121 1.00 42.90 ? 427 ILE   A C   1 
ATOM   2995 O O   . ILE   A 1 427 ? -23.181 -27.512 -9.966  1.00 43.91 ? 427 ILE   A O   1 
ATOM   2996 C CB  . ILE   A 1 427 ? -23.811 -30.260 -8.684  1.00 45.01 ? 427 ILE   A CB  1 
ATOM   2997 C CG1 . ILE   A 1 427 ? -23.730 -31.114 -7.423  1.00 44.16 ? 427 ILE   A CG1 1 
ATOM   2998 C CG2 . ILE   A 1 427 ? -24.233 -31.105 -9.875  1.00 40.83 ? 427 ILE   A CG2 1 
ATOM   2999 C CD1 . ILE   A 1 427 ? -24.992 -31.897 -7.137  1.00 43.73 ? 427 ILE   A CD1 1 
ATOM   3000 N N   . ASN   A 1 428 ? -22.049 -28.959 -11.273 1.00 43.12 ? 428 ASN   A N   1 
ATOM   3001 C CA  . ASN   A 1 428 ? -22.078 -28.113 -12.453 1.00 41.49 ? 428 ASN   A CA  1 
ATOM   3002 C C   . ASN   A 1 428 ? -22.868 -28.782 -13.569 1.00 41.85 ? 428 ASN   A C   1 
ATOM   3003 O O   . ASN   A 1 428 ? -23.100 -29.994 -13.562 1.00 42.30 ? 428 ASN   A O   1 
ATOM   3004 C CB  . ASN   A 1 428 ? -20.661 -27.787 -12.939 1.00 39.87 ? 428 ASN   A CB  1 
ATOM   3005 C CG  . ASN   A 1 428 ? -20.083 -26.561 -12.263 1.00 40.62 ? 428 ASN   A CG  1 
ATOM   3006 O OD1 . ASN   A 1 428 ? -20.383 -26.283 -11.102 1.00 44.48 ? 428 ASN   A OD1 1 
ATOM   3007 N ND2 . ASN   A 1 428 ? -19.255 -25.815 -12.988 1.00 39.03 ? 428 ASN   A ND2 1 
ATOM   3008 N N   . LEU   A 1 429 ? -23.277 -27.966 -14.534 1.00 43.35 ? 429 LEU   A N   1 
ATOM   3009 C CA  . LEU   A 1 429 ? -24.006 -28.427 -15.705 1.00 41.17 ? 429 LEU   A CA  1 
ATOM   3010 C C   . LEU   A 1 429 ? -23.100 -28.371 -16.926 1.00 39.98 ? 429 LEU   A C   1 
ATOM   3011 O O   . LEU   A 1 429 ? -22.293 -27.449 -17.071 1.00 40.98 ? 429 LEU   A O   1 
ATOM   3012 C CB  . LEU   A 1 429 ? -25.254 -27.572 -15.938 1.00 39.86 ? 429 LEU   A CB  1 
ATOM   3013 C CG  . LEU   A 1 429 ? -25.997 -27.708 -17.271 1.00 38.97 ? 429 LEU   A CG  1 
ATOM   3014 C CD1 . LEU   A 1 429 ? -26.584 -29.104 -17.446 1.00 40.74 ? 429 LEU   A CD1 1 
ATOM   3015 C CD2 . LEU   A 1 429 ? -27.085 -26.651 -17.384 1.00 39.85 ? 429 LEU   A CD2 1 
ATOM   3016 N N   . GLN   A 1 430 ? -23.226 -29.368 -17.795 1.00 41.12 ? 430 GLN   A N   1 
ATOM   3017 C CA  . GLN   A 1 430 ? -22.520 -29.381 -19.068 1.00 40.00 ? 430 GLN   A CA  1 
ATOM   3018 C C   . GLN   A 1 430 ? -23.503 -29.031 -20.177 1.00 40.19 ? 430 GLN   A C   1 
ATOM   3019 O O   . GLN   A 1 430 ? -24.522 -29.710 -20.350 1.00 39.43 ? 430 GLN   A O   1 
ATOM   3020 C CB  . GLN   A 1 430 ? -21.868 -30.736 -19.337 1.00 40.10 ? 430 GLN   A CB  1 
ATOM   3021 C CG  . GLN   A 1 430 ? -21.246 -30.819 -20.718 1.00 38.65 ? 430 GLN   A CG  1 
ATOM   3022 C CD  . GLN   A 1 430 ? -20.373 -32.039 -20.899 1.00 42.77 ? 430 GLN   A CD  1 
ATOM   3023 O OE1 . GLN   A 1 430 ? -19.355 -31.987 -21.590 1.00 42.81 ? 430 GLN   A OE1 1 
ATOM   3024 N NE2 . GLN   A 1 430 ? -20.773 -33.151 -20.293 1.00 44.81 ? 430 GLN   A NE2 1 
ATOM   3025 N N   . ILE   A 1 431 ? -23.197 -27.973 -20.918 1.00 41.73 ? 431 ILE   A N   1 
ATOM   3026 C CA  . ILE   A 1 431 ? -24.026 -27.502 -22.019 1.00 40.98 ? 431 ILE   A CA  1 
ATOM   3027 C C   . ILE   A 1 431 ? -23.224 -27.674 -23.301 1.00 41.11 ? 431 ILE   A C   1 
ATOM   3028 O O   . ILE   A 1 431 ? -22.246 -26.955 -23.535 1.00 41.39 ? 431 ILE   A O   1 
ATOM   3029 C CB  . ILE   A 1 431 ? -24.457 -26.043 -21.827 1.00 37.49 ? 431 ILE   A CB  1 
ATOM   3030 C CG1 . ILE   A 1 431 ? -25.209 -25.880 -20.503 1.00 39.27 ? 431 ILE   A CG1 1 
ATOM   3031 C CG2 . ILE   A 1 431 ? -25.310 -25.584 -22.995 1.00 41.97 ? 431 ILE   A CG2 1 
ATOM   3032 C CD1 . ILE   A 1 431 ? -25.682 -24.472 -20.239 1.00 36.93 ? 431 ILE   A CD1 1 
ATOM   3033 N N   . ILE   A 1 432 ? -23.639 -28.621 -24.133 1.00 39.92 ? 432 ILE   A N   1 
ATOM   3034 C CA  . ILE   A 1 432 ? -22.972 -28.912 -25.395 1.00 40.32 ? 432 ILE   A CA  1 
ATOM   3035 C C   . ILE   A 1 432 ? -23.805 -28.317 -26.523 1.00 40.85 ? 432 ILE   A C   1 
ATOM   3036 O O   . ILE   A 1 432 ? -24.993 -28.633 -26.661 1.00 40.40 ? 432 ILE   A O   1 
ATOM   3037 C CB  . ILE   A 1 432 ? -22.782 -30.424 -25.592 1.00 42.85 ? 432 ILE   A CB  1 
ATOM   3038 C CG1 . ILE   A 1 432 ? -22.245 -31.069 -24.317 1.00 39.69 ? 432 ILE   A CG1 1 
ATOM   3039 C CG2 . ILE   A 1 432 ? -21.844 -30.690 -26.766 1.00 39.87 ? 432 ILE   A CG2 1 
ATOM   3040 C CD1 . ILE   A 1 432 ? -22.189 -32.579 -24.374 1.00 39.28 ? 432 ILE   A CD1 1 
ATOM   3041 N N   . THR   A 1 433 ? -23.189 -27.457 -27.328 1.00 40.30 ? 433 THR   A N   1 
ATOM   3042 C CA  . THR   A 1 433 ? -23.817 -26.889 -28.511 1.00 39.24 ? 433 THR   A CA  1 
ATOM   3043 C C   . THR   A 1 433 ? -23.044 -27.328 -29.748 1.00 42.42 ? 433 THR   A C   1 
ATOM   3044 O O   . THR   A 1 433 ? -21.971 -27.929 -29.657 1.00 39.98 ? 433 THR   A O   1 
ATOM   3045 C CB  . THR   A 1 433 ? -23.881 -25.359 -28.429 1.00 41.34 ? 433 THR   A CB  1 
ATOM   3046 O OG1 . THR   A 1 433 ? -22.554 -24.821 -28.407 1.00 40.64 ? 433 THR   A OG1 1 
ATOM   3047 C CG2 . THR   A 1 433 ? -24.622 -24.925 -27.167 1.00 41.25 ? 433 THR   A CG2 1 
ATOM   3048 N N   . ARG   A 1 434 ? -23.599 -27.015 -30.917 1.00 42.50 ? 434 ARG   A N   1 
ATOM   3049 C CA  . ARG   A 1 434 ? -22.993 -27.445 -32.167 1.00 42.40 ? 434 ARG   A CA  1 
ATOM   3050 C C   . ARG   A 1 434 ? -21.637 -26.775 -32.370 1.00 42.18 ? 434 ARG   A C   1 
ATOM   3051 O O   . ARG   A 1 434 ? -21.301 -25.777 -31.723 1.00 41.94 ? 434 ARG   A O   1 
ATOM   3052 C CB  . ARG   A 1 434 ? -23.915 -27.139 -33.349 1.00 44.20 ? 434 ARG   A CB  1 
ATOM   3053 C CG  . ARG   A 1 434 ? -24.028 -25.661 -33.696 1.00 44.75 ? 434 ARG   A CG  1 
ATOM   3054 C CD  . ARG   A 1 434 ? -25.006 -25.447 -34.839 1.00 47.13 ? 434 ARG   A CD  1 
ATOM   3055 N NE  . ARG   A 1 434 ? -25.156 -24.037 -35.180 1.00 51.15 ? 434 ARG   A NE  1 
ATOM   3056 C CZ  . ARG   A 1 434 ? -24.485 -23.423 -36.144 1.00 56.62 ? 434 ARG   A CZ  1 
ATOM   3057 N NH1 . ARG   A 1 434 ? -23.609 -24.068 -36.894 1.00 56.43 ? 434 ARG   A NH1 1 
ATOM   3058 N NH2 . ARG   A 1 434 ? -24.703 -22.129 -36.363 1.00 59.31 ? 434 ARG   A NH2 1 
ATOM   3059 N N   . ASN   A 1 435 ? -20.851 -27.351 -33.280 1.00 44.55 ? 435 ASN   A N   1 
ATOM   3060 C CA  . ASN   A 1 435 ? -19.507 -26.854 -33.542 1.00 41.70 ? 435 ASN   A CA  1 
ATOM   3061 C C   . ASN   A 1 435 ? -19.541 -25.387 -33.952 1.00 42.34 ? 435 ASN   A C   1 
ATOM   3062 O O   . ASN   A 1 435 ? -20.456 -24.937 -34.643 1.00 47.35 ? 435 ASN   A O   1 
ATOM   3063 C CB  . ASN   A 1 435 ? -18.835 -27.689 -34.636 1.00 40.13 ? 435 ASN   A CB  1 
ATOM   3064 C CG  . ASN   A 1 435 ? -18.137 -28.921 -34.088 1.00 43.72 ? 435 ASN   A CG  1 
ATOM   3065 O OD1 . ASN   A 1 435 ? -16.947 -28.884 -33.774 1.00 46.85 ? 435 ASN   A OD1 1 
ATOM   3066 N ND2 . ASN   A 1 435 ? -18.871 -30.022 -33.978 1.00 46.22 ? 435 ASN   A ND2 1 
ATOM   3067 N N   . TRP   A 1 436 ? -18.534 -24.641 -33.502 1.00 40.96 ? 436 TRP   A N   1 
ATOM   3068 C CA  . TRP   A 1 436 ? -18.319 -23.227 -33.806 1.00 43.15 ? 436 TRP   A CA  1 
ATOM   3069 C C   . TRP   A 1 436 ? -19.386 -22.315 -33.215 1.00 42.32 ? 436 TRP   A C   1 
ATOM   3070 O O   . TRP   A 1 436 ? -19.370 -21.105 -33.479 1.00 41.88 ? 436 TRP   A O   1 
ATOM   3071 C CB  . TRP   A 1 436 ? -18.214 -22.985 -35.315 1.00 40.20 ? 436 TRP   A CB  1 
ATOM   3072 C CG  . TRP   A 1 436 ? -17.138 -23.793 -35.967 1.00 37.75 ? 436 TRP   A CG  1 
ATOM   3073 C CD1 . TRP   A 1 436 ? -17.304 -24.871 -36.785 1.00 43.40 ? 436 TRP   A CD1 1 
ATOM   3074 C CD2 . TRP   A 1 436 ? -15.726 -23.596 -35.844 1.00 40.59 ? 436 TRP   A CD2 1 
ATOM   3075 N NE1 . TRP   A 1 436 ? -16.081 -25.361 -37.176 1.00 42.13 ? 436 TRP   A NE1 1 
ATOM   3076 C CE2 . TRP   A 1 436 ? -15.096 -24.593 -36.612 1.00 41.13 ? 436 TRP   A CE2 1 
ATOM   3077 C CE3 . TRP   A 1 436 ? -14.932 -22.674 -35.154 1.00 39.60 ? 436 TRP   A CE3 1 
ATOM   3078 C CZ2 . TRP   A 1 436 ? -13.712 -24.692 -36.712 1.00 42.13 ? 436 TRP   A CZ2 1 
ATOM   3079 C CZ3 . TRP   A 1 436 ? -13.560 -22.775 -35.257 1.00 39.98 ? 436 TRP   A CZ3 1 
ATOM   3080 C CH2 . TRP   A 1 436 ? -12.964 -23.775 -36.028 1.00 43.24 ? 436 TRP   A CH2 1 
ATOM   3081 N N   . SER   A 1 437 ? -20.318 -22.854 -32.430 1.00 43.24 ? 437 SER   A N   1 
ATOM   3082 C CA  . SER   A 1 437 ? -21.309 -22.059 -31.707 1.00 41.64 ? 437 SER   A CA  1 
ATOM   3083 C C   . SER   A 1 437 ? -20.898 -21.848 -30.256 1.00 42.01 ? 437 SER   A C   1 
ATOM   3084 O O   . SER   A 1 437 ? -21.724 -21.945 -29.341 1.00 42.91 ? 437 SER   A O   1 
ATOM   3085 C CB  . SER   A 1 437 ? -22.681 -22.721 -31.786 1.00 42.72 ? 437 SER   A CB  1 
ATOM   3086 O OG  . SER   A 1 437 ? -22.664 -24.003 -31.183 1.00 43.40 ? 437 SER   A OG  1 
ATOM   3087 N N   . ASP   A 1 438 ? -19.613 -21.553 -30.030 1.00 42.12 ? 438 ASP   A N   1 
ATOM   3088 C CA  . ASP   A 1 438 ? -19.107 -21.380 -28.673 1.00 41.86 ? 438 ASP   A CA  1 
ATOM   3089 C C   . ASP   A 1 438 ? -19.834 -20.265 -27.936 1.00 41.16 ? 438 ASP   A C   1 
ATOM   3090 O O   . ASP   A 1 438 ? -20.012 -20.344 -26.716 1.00 40.88 ? 438 ASP   A O   1 
ATOM   3091 C CB  . ASP   A 1 438 ? -17.604 -21.091 -28.704 1.00 40.15 ? 438 ASP   A CB  1 
ATOM   3092 C CG  . ASP   A 1 438 ? -16.805 -22.193 -29.377 1.00 40.34 ? 438 ASP   A CG  1 
ATOM   3093 O OD1 . ASP   A 1 438 ? -17.106 -22.521 -30.544 1.00 42.71 ? 438 ASP   A OD1 1 
ATOM   3094 O OD2 . ASP   A 1 438 ? -15.867 -22.724 -28.743 1.00 39.15 ? 438 ASP   A OD2 1 
ATOM   3095 N N   . HIS   A 1 439 ? -20.252 -19.218 -28.650 1.00 41.33 ? 439 HIS   A N   1 
ATOM   3096 C CA  . HIS   A 1 439 ? -20.953 -18.119 -27.997 1.00 40.92 ? 439 HIS   A CA  1 
ATOM   3097 C C   . HIS   A 1 439 ? -22.387 -18.487 -27.642 1.00 41.91 ? 439 HIS   A C   1 
ATOM   3098 O O   . HIS   A 1 439 ? -22.968 -17.883 -26.733 1.00 44.39 ? 439 HIS   A O   1 
ATOM   3099 C CB  . HIS   A 1 439 ? -20.931 -16.873 -28.881 1.00 38.44 ? 439 HIS   A CB  1 
ATOM   3100 C CG  . HIS   A 1 439 ? -19.644 -16.114 -28.814 1.00 40.01 ? 439 HIS   A CG  1 
ATOM   3101 N ND1 . HIS   A 1 439 ? -19.271 -15.381 -27.709 1.00 39.68 ? 439 HIS   A ND1 1 
ATOM   3102 C CD2 . HIS   A 1 439 ? -18.638 -15.982 -29.710 1.00 43.18 ? 439 HIS   A CD2 1 
ATOM   3103 C CE1 . HIS   A 1 439 ? -18.094 -14.824 -27.929 1.00 39.70 ? 439 HIS   A CE1 1 
ATOM   3104 N NE2 . HIS   A 1 439 ? -17.688 -15.172 -29.136 1.00 38.82 ? 439 HIS   A NE2 1 
ATOM   3105 N N   . ASP   A 1 440 ? -22.973 -19.458 -28.345 1.00 40.89 ? 440 ASP   A N   1 
ATOM   3106 C CA  . ASP   A 1 440 ? -24.286 -19.957 -27.953 1.00 41.51 ? 440 ASP   A CA  1 
ATOM   3107 C C   . ASP   A 1 440 ? -24.215 -20.650 -26.599 1.00 40.69 ? 440 ASP   A C   1 
ATOM   3108 O O   . ASP   A 1 440 ? -25.054 -20.413 -25.724 1.00 42.11 ? 440 ASP   A O   1 
ATOM   3109 C CB  . ASP   A 1 440 ? -24.831 -20.908 -29.019 1.00 43.94 ? 440 ASP   A CB  1 
ATOM   3110 C CG  . ASP   A 1 440 ? -25.336 -20.179 -30.244 1.00 44.54 ? 440 ASP   A CG  1 
ATOM   3111 O OD1 . ASP   A 1 440 ? -25.627 -18.971 -30.134 1.00 43.55 ? 440 ASP   A OD1 1 
ATOM   3112 O OD2 . ASP   A 1 440 ? -25.455 -20.815 -31.314 1.00 42.85 ? 440 ASP   A OD2 1 
ATOM   3113 N N   . ALA   A 1 441 ? -23.206 -21.505 -26.410 1.00 40.41 ? 441 ALA   A N   1 
ATOM   3114 C CA  . ALA   A 1 441 ? -23.031 -22.213 -25.144 1.00 41.65 ? 441 ALA   A CA  1 
ATOM   3115 C C   . ALA   A 1 441 ? -22.885 -21.241 -23.980 1.00 39.23 ? 441 ALA   A C   1 
ATOM   3116 O O   . ALA   A 1 441 ? -23.475 -21.437 -22.912 1.00 43.60 ? 441 ALA   A O   1 
ATOM   3117 C CB  . ALA   A 1 441 ? -21.814 -23.135 -25.230 1.00 39.42 ? 441 ALA   A CB  1 
ATOM   3118 N N   . ILE   A 1 442 ? -22.094 -20.184 -24.172 1.00 38.84 ? 442 ILE   A N   1 
ATOM   3119 C CA  . ILE   A 1 442 ? -21.936 -19.169 -23.133 1.00 42.67 ? 442 ILE   A CA  1 
ATOM   3120 C C   . ILE   A 1 442 ? -23.262 -18.466 -22.873 1.00 44.12 ? 442 ILE   A C   1 
ATOM   3121 O O   . ILE   A 1 442 ? -23.692 -18.314 -21.724 1.00 44.99 ? 442 ILE   A O   1 
ATOM   3122 C CB  . ILE   A 1 442 ? -20.837 -18.167 -23.530 1.00 42.18 ? 442 ILE   A CB  1 
ATOM   3123 C CG1 . ILE   A 1 442 ? -19.504 -18.885 -23.754 1.00 39.75 ? 442 ILE   A CG1 1 
ATOM   3124 C CG2 . ILE   A 1 442 ? -20.693 -17.083 -22.476 1.00 39.94 ? 442 ILE   A CG2 1 
ATOM   3125 C CD1 . ILE   A 1 442 ? -18.393 -17.959 -24.206 1.00 38.30 ? 442 ILE   A CD1 1 
ATOM   3126 N N   . ARG   A 1 443 ? -23.931 -18.030 -23.943 1.00 40.58 ? 443 ARG   A N   1 
ATOM   3127 C CA  . ARG   A 1 443 ? -25.197 -17.316 -23.801 1.00 41.73 ? 443 ARG   A CA  1 
ATOM   3128 C C   . ARG   A 1 443 ? -26.262 -18.194 -23.157 1.00 41.95 ? 443 ARG   A C   1 
ATOM   3129 O O   . ARG   A 1 443 ? -27.001 -17.737 -22.277 1.00 41.36 ? 443 ARG   A O   1 
ATOM   3130 C CB  . ARG   A 1 443 ? -25.665 -16.814 -25.168 1.00 41.91 ? 443 ARG   A CB  1 
ATOM   3131 C CG  . ARG   A 1 443 ? -27.075 -16.246 -25.185 1.00 43.46 ? 443 ARG   A CG  1 
ATOM   3132 C CD  . ARG   A 1 443 ? -27.191 -14.992 -24.335 1.00 43.45 ? 443 ARG   A CD  1 
ATOM   3133 N NE  . ARG   A 1 443 ? -26.117 -14.045 -24.611 1.00 49.15 ? 443 ARG   A NE  1 
ATOM   3134 C CZ  . ARG   A 1 443 ? -26.024 -13.303 -25.706 1.00 50.80 ? 443 ARG   A CZ  1 
ATOM   3135 N NH1 . ARG   A 1 443 ? -26.927 -13.374 -26.668 1.00 46.86 ? 443 ARG   A NH1 1 
ATOM   3136 N NH2 . ARG   A 1 443 ? -24.993 -12.474 -25.842 1.00 52.68 ? 443 ARG   A NH2 1 
ATOM   3137 N N   . ILE   A 1 444 ? -26.363 -19.453 -23.588 1.00 43.67 ? 444 ILE   A N   1 
ATOM   3138 C CA  . ILE   A 1 444 ? -27.304 -20.380 -22.964 1.00 43.05 ? 444 ILE   A CA  1 
ATOM   3139 C C   . ILE   A 1 444 ? -26.993 -20.527 -21.481 1.00 42.52 ? 444 ILE   A C   1 
ATOM   3140 O O   . ILE   A 1 444 ? -27.895 -20.497 -20.636 1.00 42.46 ? 444 ILE   A O   1 
ATOM   3141 C CB  . ILE   A 1 444 ? -27.281 -21.739 -23.690 1.00 42.85 ? 444 ILE   A CB  1 
ATOM   3142 C CG1 . ILE   A 1 444 ? -27.853 -21.595 -25.101 1.00 39.27 ? 444 ILE   A CG1 1 
ATOM   3143 C CG2 . ILE   A 1 444 ? -28.064 -22.784 -22.907 1.00 41.66 ? 444 ILE   A CG2 1 
ATOM   3144 C CD1 . ILE   A 1 444 ? -27.686 -22.831 -25.963 1.00 42.96 ? 444 ILE   A CD1 1 
ATOM   3145 N N   . GLY   A 1 445 ? -25.709 -20.657 -21.141 1.00 39.78 ? 445 GLY   A N   1 
ATOM   3146 C CA  . GLY   A 1 445 ? -25.328 -20.743 -19.740 1.00 42.27 ? 445 GLY   A CA  1 
ATOM   3147 C C   . GLY   A 1 445 ? -25.684 -19.494 -18.957 1.00 48.12 ? 445 GLY   A C   1 
ATOM   3148 O O   . GLY   A 1 445 ? -26.075 -19.571 -17.793 1.00 44.02 ? 445 GLY   A O   1 
ATOM   3149 N N   . ALA   A 1 446 ? -25.558 -18.327 -19.588 1.00 42.36 ? 446 ALA   A N   1 
ATOM   3150 C CA  . ALA   A 1 446 ? -25.959 -17.079 -18.946 1.00 45.45 ? 446 ALA   A CA  1 
ATOM   3151 C C   . ALA   A 1 446 ? -27.459 -17.059 -18.687 1.00 48.89 ? 446 ALA   A C   1 
ATOM   3152 O O   . ALA   A 1 446 ? -27.909 -16.669 -17.605 1.00 48.65 ? 446 ALA   A O   1 
ATOM   3153 C CB  . ALA   A 1 446 ? -25.540 -15.887 -19.812 1.00 39.59 ? 446 ALA   A CB  1 
ATOM   3154 N N   . LEU   A 1 447 ? -28.252 -17.488 -19.670 1.00 47.02 ? 447 LEU   A N   1 
ATOM   3155 C CA  . LEU   A 1 447 ? -29.701 -17.496 -19.502 1.00 50.31 ? 447 LEU   A CA  1 
ATOM   3156 C C   . LEU   A 1 447 ? -30.151 -18.568 -18.517 1.00 50.50 ? 447 LEU   A C   1 
ATOM   3157 O O   . LEU   A 1 447 ? -31.168 -18.392 -17.838 1.00 53.07 ? 447 LEU   A O   1 
ATOM   3158 C CB  . LEU   A 1 447 ? -30.382 -17.697 -20.855 1.00 49.15 ? 447 LEU   A CB  1 
ATOM   3159 C CG  . LEU   A 1 447 ? -30.118 -16.611 -21.899 1.00 48.37 ? 447 LEU   A CG  1 
ATOM   3160 C CD1 . LEU   A 1 447 ? -30.629 -17.050 -23.262 1.00 46.69 ? 447 LEU   A CD1 1 
ATOM   3161 C CD2 . LEU   A 1 447 ? -30.760 -15.295 -21.481 1.00 46.05 ? 447 LEU   A CD2 1 
ATOM   3162 N N   . VAL   A 1 448 ? -29.417 -19.679 -18.429 1.00 50.57 ? 448 VAL   A N   1 
ATOM   3163 C CA  . VAL   A 1 448 ? -29.778 -20.729 -17.482 1.00 49.12 ? 448 VAL   A CA  1 
ATOM   3164 C C   . VAL   A 1 448 ? -29.560 -20.255 -16.050 1.00 51.13 ? 448 VAL   A C   1 
ATOM   3165 O O   . VAL   A 1 448 ? -30.364 -20.547 -15.156 1.00 53.33 ? 448 VAL   A O   1 
ATOM   3166 C CB  . VAL   A 1 448 ? -28.989 -22.016 -17.788 1.00 49.20 ? 448 VAL   A CB  1 
ATOM   3167 C CG1 . VAL   A 1 448 ? -29.058 -22.985 -16.616 1.00 47.13 ? 448 VAL   A CG1 1 
ATOM   3168 C CG2 . VAL   A 1 448 ? -29.528 -22.679 -19.049 1.00 45.10 ? 448 VAL   A CG2 1 
ATOM   3169 N N   . ALA   A 1 449 ? -28.483 -19.503 -15.812 1.00 52.27 ? 449 ALA   A N   1 
ATOM   3170 C CA  . ALA   A 1 449 ? -28.222 -18.988 -14.471 1.00 50.50 ? 449 ALA   A CA  1 
ATOM   3171 C C   . ALA   A 1 449 ? -29.309 -18.017 -14.030 1.00 55.34 ? 449 ALA   A C   1 
ATOM   3172 O O   . ALA   A 1 449 ? -29.737 -18.037 -12.870 1.00 57.31 ? 449 ALA   A O   1 
ATOM   3173 C CB  . ALA   A 1 449 ? -26.850 -18.315 -14.424 1.00 46.64 ? 449 ALA   A CB  1 
ATOM   3174 N N   . GLU   A 1 450 ? -29.769 -17.157 -14.943 1.00 55.70 ? 450 GLU   A N   1 
ATOM   3175 C CA  . GLU   A 1 450 ? -30.854 -16.237 -14.614 1.00 59.68 ? 450 GLU   A CA  1 
ATOM   3176 C C   . GLU   A 1 450 ? -32.154 -16.986 -14.353 1.00 60.74 ? 450 GLU   A C   1 
ATOM   3177 O O   . GLU   A 1 450 ? -32.921 -16.618 -13.454 1.00 62.41 ? 450 GLU   A O   1 
ATOM   3178 C CB  . GLU   A 1 450 ? -31.043 -15.218 -15.741 1.00 59.72 ? 450 GLU   A CB  1 
ATOM   3179 C CG  . GLU   A 1 450 ? -29.982 -14.126 -15.794 1.00 64.24 ? 450 GLU   A CG  1 
ATOM   3180 C CD  . GLU   A 1 450 ? -30.171 -13.194 -16.972 1.00 76.85 ? 450 GLU   A CD  1 
ATOM   3181 O OE1 . GLU   A 1 450 ? -31.199 -13.315 -17.668 1.00 74.19 ? 450 GLU   A OE1 1 
ATOM   3182 O OE2 . GLU   A 1 450 ? -29.294 -12.341 -17.206 1.00 75.09 ? 450 GLU   A OE2 1 
ATOM   3183 N N   . ALA   A 1 451 ? -32.430 -18.030 -15.138 1.00 58.33 ? 451 ALA   A N   1 
ATOM   3184 C CA  . ALA   A 1 451 ? -33.644 -18.810 -14.926 1.00 57.99 ? 451 ALA   A CA  1 
ATOM   3185 C C   . ALA   A 1 451 ? -33.611 -19.523 -13.581 1.00 59.32 ? 451 ALA   A C   1 
ATOM   3186 O O   . ALA   A 1 451 ? -34.643 -19.641 -12.909 1.00 59.46 ? 451 ALA   A O   1 
ATOM   3187 C CB  . ALA   A 1 451 ? -33.835 -19.810 -16.066 1.00 54.75 ? 451 ALA   A CB  1 
ATOM   3188 N N   . LEU   A 1 452 ? -32.435 -20.005 -13.170 1.00 58.24 ? 452 LEU   A N   1 
ATOM   3189 C CA  . LEU   A 1 452 ? -32.305 -20.600 -11.845 1.00 58.08 ? 452 LEU   A CA  1 
ATOM   3190 C C   . LEU   A 1 452 ? -32.468 -19.558 -10.748 1.00 61.23 ? 452 LEU   A C   1 
ATOM   3191 O O   . LEU   A 1 452 ? -32.892 -19.891 -9.635  1.00 64.87 ? 452 LEU   A O   1 
ATOM   3192 C CB  . LEU   A 1 452 ? -30.955 -21.301 -11.710 1.00 56.44 ? 452 LEU   A CB  1 
ATOM   3193 C CG  . LEU   A 1 452 ? -30.728 -22.517 -12.608 1.00 53.84 ? 452 LEU   A CG  1 
ATOM   3194 C CD1 . LEU   A 1 452 ? -29.282 -22.960 -12.522 1.00 48.70 ? 452 LEU   A CD1 1 
ATOM   3195 C CD2 . LEU   A 1 452 ? -31.667 -23.652 -12.226 1.00 50.49 ? 452 LEU   A CD2 1 
ATOM   3196 N N   . ASP   A 1 453 ? -32.130 -18.299 -11.037 1.00 62.94 ? 453 ASP   A N   1 
ATOM   3197 C CA  . ASP   A 1 453 ? -32.384 -17.230 -10.079 1.00 67.92 ? 453 ASP   A CA  1 
ATOM   3198 C C   . ASP   A 1 453 ? -33.876 -17.029 -9.853  1.00 70.21 ? 453 ASP   A C   1 
ATOM   3199 O O   . ASP   A 1 453 ? -34.290 -16.650 -8.752  1.00 69.81 ? 453 ASP   A O   1 
ATOM   3200 C CB  . ASP   A 1 453 ? -31.743 -15.929 -10.559 1.00 69.35 ? 453 ASP   A CB  1 
ATOM   3201 C CG  . ASP   A 1 453 ? -30.854 -15.298 -9.509  1.00 76.90 ? 453 ASP   A CG  1 
ATOM   3202 O OD1 . ASP   A 1 453 ? -30.570 -15.964 -8.492  1.00 75.35 ? 453 ASP   A OD1 1 
ATOM   3203 O OD2 . ASP   A 1 453 ? -30.438 -14.136 -9.701  1.00 81.34 ? 453 ASP   A OD2 1 
ATOM   3204 N N   . ARG   A 1 454 ? -34.691 -17.276 -10.874 1.00 68.44 ? 454 ARG   A N   1 
ATOM   3205 C CA  . ARG   A 1 454 ? -36.140 -17.180 -10.750 1.00 69.25 ? 454 ARG   A CA  1 
ATOM   3206 C C   . ARG   A 1 454 ? -36.721 -18.479 -10.203 1.00 71.59 ? 454 ARG   A C   1 
ATOM   3207 O O   . ARG   A 1 454 ? -36.360 -18.921 -9.112  1.00 70.79 ? 454 ARG   A O   1 
ATOM   3208 C CB  . ARG   A 1 454 ? -36.774 -16.846 -12.101 1.00 66.24 ? 454 ARG   A CB  1 
ATOM   3209 C CG  . ARG   A 1 454 ? -36.471 -15.445 -12.607 1.00 69.98 ? 454 ARG   A CG  1 
ATOM   3210 C CD  . ARG   A 1 454 ? -36.973 -15.265 -14.030 1.00 64.81 ? 454 ARG   A CD  1 
ATOM   3211 N NE  . ARG   A 1 454 ? -36.268 -16.135 -14.962 1.00 67.67 ? 454 ARG   A NE  1 
ATOM   3212 C CZ  . ARG   A 1 454 ? -36.542 -16.229 -16.256 1.00 63.65 ? 454 ARG   A CZ  1 
ATOM   3213 N NH1 . ARG   A 1 454 ? -37.518 -15.528 -16.808 1.00 68.86 ? 454 ARG   A NH1 1 
ATOM   3214 N NH2 . ARG   A 1 454 ? -35.818 -17.047 -17.015 1.00 59.62 ? 454 ARG   A NH2 1 
ATOM   3215 N N   . GLU   B 1 18  ? -18.911 -11.510 -70.611 1.00 48.14 ? 18  GLU   B N   1 
ATOM   3216 C CA  . GLU   B 1 18  ? -20.011 -12.264 -70.025 1.00 50.07 ? 18  GLU   B CA  1 
ATOM   3217 C C   . GLU   B 1 18  ? -20.348 -11.753 -68.628 1.00 48.43 ? 18  GLU   B C   1 
ATOM   3218 O O   . GLU   B 1 18  ? -19.489 -11.209 -67.934 1.00 48.82 ? 18  GLU   B O   1 
ATOM   3219 C CB  . GLU   B 1 18  ? -19.669 -13.754 -69.976 1.00 46.37 ? 18  GLU   B CB  1 
ATOM   3220 C CG  . GLU   B 1 18  ? -19.360 -14.373 -71.331 1.00 48.07 ? 18  GLU   B CG  1 
ATOM   3221 C CD  . GLU   B 1 18  ? -20.596 -14.603 -72.178 1.00 51.08 ? 18  GLU   B CD  1 
ATOM   3222 O OE1 . GLU   B 1 18  ? -21.705 -14.236 -71.739 1.00 50.33 ? 18  GLU   B OE1 1 
ATOM   3223 O OE2 . GLU   B 1 18  ? -20.457 -15.159 -73.287 1.00 55.46 ? 18  GLU   B OE2 1 
ATOM   3224 N N   . LEU   B 1 19  ? -21.607 -11.916 -68.226 1.00 47.96 ? 19  LEU   B N   1 
ATOM   3225 C CA  . LEU   B 1 19  ? -22.014 -11.511 -66.888 1.00 45.52 ? 19  LEU   B CA  1 
ATOM   3226 C C   . LEU   B 1 19  ? -21.318 -12.371 -65.842 1.00 49.73 ? 19  LEU   B C   1 
ATOM   3227 O O   . LEU   B 1 19  ? -21.193 -13.588 -66.000 1.00 49.21 ? 19  LEU   B O   1 
ATOM   3228 C CB  . LEU   B 1 19  ? -23.531 -11.625 -66.726 1.00 44.64 ? 19  LEU   B CB  1 
ATOM   3229 C CG  . LEU   B 1 19  ? -24.410 -10.660 -67.522 1.00 48.05 ? 19  LEU   B CG  1 
ATOM   3230 C CD1 . LEU   B 1 19  ? -25.844 -10.707 -67.012 1.00 46.98 ? 19  LEU   B CD1 1 
ATOM   3231 C CD2 . LEU   B 1 19  ? -23.850 -9.251  -67.447 1.00 45.94 ? 19  LEU   B CD2 1 
ATOM   3232 N N   . SER   B 1 20  ? -20.867 -11.733 -64.765 1.00 48.69 ? 20  SER   B N   1 
ATOM   3233 C CA  . SER   B 1 20  ? -20.249 -12.455 -63.662 1.00 46.50 ? 20  SER   B CA  1 
ATOM   3234 C C   . SER   B 1 20  ? -21.347 -13.073 -62.796 1.00 47.09 ? 20  SER   B C   1 
ATOM   3235 O O   . SER   B 1 20  ? -22.527 -13.078 -63.156 1.00 48.49 ? 20  SER   B O   1 
ATOM   3236 C CB  . SER   B 1 20  ? -19.334 -11.532 -62.861 1.00 46.94 ? 20  SER   B CB  1 
ATOM   3237 O OG  . SER   B 1 20  ? -20.078 -10.665 -62.027 1.00 47.84 ? 20  SER   B OG  1 
ATOM   3238 N N   . ALA   B 1 21  ? -20.967 -13.607 -61.634 1.00 42.38 ? 21  ALA   B N   1 
ATOM   3239 C CA  . ALA   B 1 21  ? -21.939 -14.239 -60.747 1.00 43.67 ? 21  ALA   B CA  1 
ATOM   3240 C C   . ALA   B 1 21  ? -22.843 -13.206 -60.086 1.00 45.66 ? 21  ALA   B C   1 
ATOM   3241 O O   . ALA   B 1 21  ? -24.070 -13.359 -60.074 1.00 43.26 ? 21  ALA   B O   1 
ATOM   3242 C CB  . ALA   B 1 21  ? -21.218 -15.079 -59.690 1.00 46.31 ? 21  ALA   B CB  1 
ATOM   3243 N N   . ILE   B 1 22  ? -22.252 -12.146 -59.527 1.00 46.69 ? 22  ILE   B N   1 
ATOM   3244 C CA  . ILE   B 1 22  ? -23.053 -11.100 -58.896 1.00 44.49 ? 22  ILE   B CA  1 
ATOM   3245 C C   . ILE   B 1 22  ? -23.874 -10.360 -59.943 1.00 47.15 ? 22  ILE   B C   1 
ATOM   3246 O O   . ILE   B 1 22  ? -25.051 -10.045 -59.723 1.00 48.97 ? 22  ILE   B O   1 
ATOM   3247 C CB  . ILE   B 1 22  ? -22.147 -10.144 -58.097 1.00 45.86 ? 22  ILE   B CB  1 
ATOM   3248 C CG1 . ILE   B 1 22  ? -21.541 -10.865 -56.889 1.00 42.65 ? 22  ILE   B CG1 1 
ATOM   3249 C CG2 . ILE   B 1 22  ? -22.921 -8.908  -57.654 1.00 45.38 ? 22  ILE   B CG2 1 
ATOM   3250 C CD1 . ILE   B 1 22  ? -20.520 -10.039 -56.132 1.00 42.58 ? 22  ILE   B CD1 1 
ATOM   3251 N N   . GLU   B 1 23  ? -23.271 -10.081 -61.103 1.00 46.15 ? 23  GLU   B N   1 
ATOM   3252 C CA  . GLU   B 1 23  ? -23.998 -9.426  -62.185 1.00 47.84 ? 23  GLU   B CA  1 
ATOM   3253 C C   . GLU   B 1 23  ? -25.186 -10.264 -62.641 1.00 48.00 ? 23  GLU   B C   1 
ATOM   3254 O O   . GLU   B 1 23  ? -26.262 -9.726  -62.926 1.00 47.95 ? 23  GLU   B O   1 
ATOM   3255 C CB  . GLU   B 1 23  ? -23.058 -9.158  -63.361 1.00 49.02 ? 23  GLU   B CB  1 
ATOM   3256 C CG  . GLU   B 1 23  ? -21.897 -8.228  -63.044 1.00 50.44 ? 23  GLU   B CG  1 
ATOM   3257 C CD  . GLU   B 1 23  ? -20.948 -8.061  -64.216 1.00 55.06 ? 23  GLU   B CD  1 
ATOM   3258 O OE1 . GLU   B 1 23  ? -21.165 -8.716  -65.256 1.00 56.56 ? 23  GLU   B OE1 1 
ATOM   3259 O OE2 . GLU   B 1 23  ? -19.982 -7.277  -64.098 1.00 62.97 ? 23  GLU   B OE2 1 
ATOM   3260 N N   . THR   B 1 24  ? -25.007 -11.586 -62.727 1.00 46.64 ? 24  THR   B N   1 
ATOM   3261 C CA  . THR   B 1 24  ? -26.109 -12.455 -63.126 1.00 46.51 ? 24  THR   B CA  1 
ATOM   3262 C C   . THR   B 1 24  ? -27.246 -12.389 -62.117 1.00 46.68 ? 24  THR   B C   1 
ATOM   3263 O O   . THR   B 1 24  ? -28.419 -12.311 -62.498 1.00 46.53 ? 24  THR   B O   1 
ATOM   3264 C CB  . THR   B 1 24  ? -25.620 -13.897 -63.284 1.00 43.66 ? 24  THR   B CB  1 
ATOM   3265 O OG1 . THR   B 1 24  ? -24.512 -13.931 -64.192 1.00 44.12 ? 24  THR   B OG1 1 
ATOM   3266 C CG2 . THR   B 1 24  ? -26.734 -14.787 -63.820 1.00 40.88 ? 24  THR   B CG2 1 
ATOM   3267 N N   . ALA   B 1 25  ? -26.915 -12.408 -60.823 1.00 46.95 ? 25  ALA   B N   1 
ATOM   3268 C CA  . ALA   B 1 25  ? -27.945 -12.301 -59.797 1.00 45.91 ? 25  ALA   B CA  1 
ATOM   3269 C C   . ALA   B 1 25  ? -28.660 -10.958 -59.870 1.00 47.74 ? 25  ALA   B C   1 
ATOM   3270 O O   . ALA   B 1 25  ? -29.883 -10.885 -59.695 1.00 49.17 ? 25  ALA   B O   1 
ATOM   3271 C CB  . ALA   B 1 25  ? -27.332 -12.507 -58.412 1.00 45.73 ? 25  ALA   B CB  1 
ATOM   3272 N N   . ALA   B 1 26  ? -27.914 -9.882  -60.132 1.00 49.68 ? 26  ALA   B N   1 
ATOM   3273 C CA  . ALA   B 1 26  ? -28.534 -8.565  -60.214 1.00 49.40 ? 26  ALA   B CA  1 
ATOM   3274 C C   . ALA   B 1 26  ? -29.379 -8.425  -61.473 1.00 50.70 ? 26  ALA   B C   1 
ATOM   3275 O O   . ALA   B 1 26  ? -30.427 -7.769  -61.453 1.00 51.74 ? 26  ALA   B O   1 
ATOM   3276 C CB  . ALA   B 1 26  ? -27.465 -7.476  -60.160 1.00 47.36 ? 26  ALA   B CB  1 
ATOM   3277 N N   . ALA   B 1 27  ? -28.941 -9.033  -62.580 1.00 50.53 ? 27  ALA   B N   1 
ATOM   3278 C CA  . ALA   B 1 27  ? -29.697 -8.938  -63.825 1.00 47.59 ? 27  ALA   B CA  1 
ATOM   3279 C C   . ALA   B 1 27  ? -31.018 -9.691  -63.731 1.00 49.81 ? 27  ALA   B C   1 
ATOM   3280 O O   . ALA   B 1 27  ? -32.055 -9.196  -64.190 1.00 51.58 ? 27  ALA   B O   1 
ATOM   3281 C CB  . ALA   B 1 27  ? -28.860 -9.463  -64.992 1.00 47.29 ? 27  ALA   B CB  1 
ATOM   3282 N N   . ILE   B 1 28  ? -31.002 -10.886 -63.138 1.00 50.17 ? 28  ILE   B N   1 
ATOM   3283 C CA  . ILE   B 1 28  ? -32.238 -11.645 -62.959 1.00 49.88 ? 28  ILE   B CA  1 
ATOM   3284 C C   . ILE   B 1 28  ? -33.182 -10.904 -62.023 1.00 52.71 ? 28  ILE   B C   1 
ATOM   3285 O O   . ILE   B 1 28  ? -34.382 -10.781 -62.290 1.00 51.96 ? 28  ILE   B O   1 
ATOM   3286 C CB  . ILE   B 1 28  ? -31.934 -13.060 -62.438 1.00 48.50 ? 28  ILE   B CB  1 
ATOM   3287 C CG1 . ILE   B 1 28  ? -31.002 -13.800 -63.393 1.00 49.15 ? 28  ILE   B CG1 1 
ATOM   3288 C CG2 . ILE   B 1 28  ? -33.222 -13.841 -62.252 1.00 47.91 ? 28  ILE   B CG2 1 
ATOM   3289 C CD1 . ILE   B 1 28  ? -30.503 -15.112 -62.838 1.00 45.05 ? 28  ILE   B CD1 1 
ATOM   3290 N N   . ALA   B 1 29  ? -32.654 -10.407 -60.903 1.00 48.75 ? 29  ALA   B N   1 
ATOM   3291 C CA  . ALA   B 1 29  ? -33.489 -9.685  -59.950 1.00 49.57 ? 29  ALA   B CA  1 
ATOM   3292 C C   . ALA   B 1 29  ? -34.057 -8.413  -60.562 1.00 53.28 ? 29  ALA   B C   1 
ATOM   3293 O O   . ALA   B 1 29  ? -35.182 -8.018  -60.238 1.00 55.31 ? 29  ALA   B O   1 
ATOM   3294 C CB  . ALA   B 1 29  ? -32.687 -9.359  -58.687 1.00 49.71 ? 29  ALA   B CB  1 
ATOM   3295 N N   . GLY   B 1 30  ? -33.312 -7.777  -61.460 1.00 52.51 ? 30  GLY   B N   1 
ATOM   3296 C CA  . GLY   B 1 30  ? -33.725 -6.553  -62.111 1.00 50.91 ? 30  GLY   B CA  1 
ATOM   3297 C C   . GLY   B 1 30  ? -34.588 -6.717  -63.344 1.00 52.57 ? 30  GLY   B C   1 
ATOM   3298 O O   . GLY   B 1 30  ? -34.905 -5.717  -63.997 1.00 52.24 ? 30  GLY   B O   1 
ATOM   3299 N N   . GLY   B 1 31  ? -34.974 -7.940  -63.692 1.00 52.18 ? 31  GLY   B N   1 
ATOM   3300 C CA  . GLY   B 1 31  ? -35.859 -8.160  -64.816 1.00 51.10 ? 31  GLY   B CA  1 
ATOM   3301 C C   . GLY   B 1 31  ? -35.191 -8.262  -66.167 1.00 55.41 ? 31  GLY   B C   1 
ATOM   3302 O O   . GLY   B 1 31  ? -35.896 -8.375  -67.177 1.00 59.49 ? 31  GLY   B O   1 
ATOM   3303 N N   . SER   B 1 32  ? -33.859 -8.216  -66.229 1.00 51.06 ? 32  SER   B N   1 
ATOM   3304 C CA  . SER   B 1 32  ? -33.178 -8.401  -67.505 1.00 54.20 ? 32  SER   B CA  1 
ATOM   3305 C C   . SER   B 1 32  ? -33.397 -9.797  -68.067 1.00 53.98 ? 32  SER   B C   1 
ATOM   3306 O O   . SER   B 1 32  ? -33.296 -9.989  -69.284 1.00 55.17 ? 32  SER   B O   1 
ATOM   3307 C CB  . SER   B 1 32  ? -31.679 -8.130  -67.352 1.00 54.88 ? 32  SER   B CB  1 
ATOM   3308 O OG  . SER   B 1 32  ? -31.423 -6.743  -67.224 1.00 57.19 ? 32  SER   B OG  1 
ATOM   3309 N N   . MET   B 1 33  ? -33.697 -10.765 -67.208 1.00 53.48 ? 33  MET   B N   1 
ATOM   3310 C CA  . MET   B 1 33  ? -33.908 -12.152 -67.595 1.00 52.57 ? 33  MET   B CA  1 
ATOM   3311 C C   . MET   B 1 33  ? -34.469 -12.884 -66.387 1.00 52.64 ? 33  MET   B C   1 
ATOM   3312 O O   . MET   B 1 33  ? -34.320 -12.433 -65.249 1.00 52.77 ? 33  MET   B O   1 
ATOM   3313 C CB  . MET   B 1 33  ? -32.609 -12.812 -68.074 1.00 52.18 ? 33  MET   B CB  1 
ATOM   3314 C CG  . MET   B 1 33  ? -31.557 -12.969 -66.987 1.00 54.51 ? 33  MET   B CG  1 
ATOM   3315 S SD  . MET   B 1 33  ? -29.912 -13.332 -67.633 1.00 62.05 ? 33  MET   B SD  1 
ATOM   3316 C CE  . MET   B 1 33  ? -29.355 -11.693 -68.091 1.00 57.38 ? 33  MET   B CE  1 
ATOM   3317 N N   . THR   B 1 34  ? -35.123 -14.008 -66.647 1.00 52.96 ? 34  THR   B N   1 
ATOM   3318 C CA  . THR   B 1 34  ? -35.584 -14.873 -65.574 1.00 48.36 ? 34  THR   B CA  1 
ATOM   3319 C C   . THR   B 1 34  ? -34.515 -15.909 -65.245 1.00 49.55 ? 34  THR   B C   1 
ATOM   3320 O O   . THR   B 1 34  ? -33.569 -16.124 -66.007 1.00 48.34 ? 34  THR   B O   1 
ATOM   3321 C CB  . THR   B 1 34  ? -36.892 -15.571 -65.952 1.00 49.03 ? 34  THR   B CB  1 
ATOM   3322 O OG1 . THR   B 1 34  ? -36.709 -16.306 -67.167 1.00 51.48 ? 34  THR   B OG1 1 
ATOM   3323 C CG2 . THR   B 1 34  ? -38.005 -14.554 -66.148 1.00 51.14 ? 34  THR   B CG2 1 
ATOM   3324 N N   . ALA   B 1 35  ? -34.673 -16.547 -64.083 1.00 51.27 ? 35  ALA   B N   1 
ATOM   3325 C CA  . ALA   B 1 35  ? -33.736 -17.593 -63.685 1.00 49.05 ? 35  ALA   B CA  1 
ATOM   3326 C C   . ALA   B 1 35  ? -33.738 -18.738 -64.688 1.00 46.82 ? 35  ALA   B C   1 
ATOM   3327 O O   . ALA   B 1 35  ? -32.695 -19.350 -64.947 1.00 47.46 ? 35  ALA   B O   1 
ATOM   3328 C CB  . ALA   B 1 35  ? -34.076 -18.104 -62.285 1.00 45.02 ? 35  ALA   B CB  1 
ATOM   3329 N N   . LEU   B 1 36  ? -34.905 -19.041 -65.263 1.00 47.34 ? 36  LEU   B N   1 
ATOM   3330 C CA  . LEU   B 1 36  ? -34.975 -20.048 -66.316 1.00 49.69 ? 36  LEU   B CA  1 
ATOM   3331 C C   . LEU   B 1 36  ? -34.316 -19.551 -67.595 1.00 46.68 ? 36  LEU   B C   1 
ATOM   3332 O O   . LEU   B 1 36  ? -33.621 -20.313 -68.278 1.00 46.74 ? 36  LEU   B O   1 
ATOM   3333 C CB  . LEU   B 1 36  ? -36.429 -20.435 -66.577 1.00 50.63 ? 36  LEU   B CB  1 
ATOM   3334 C CG  . LEU   B 1 36  ? -36.665 -21.495 -67.653 1.00 51.72 ? 36  LEU   B CG  1 
ATOM   3335 C CD1 . LEU   B 1 36  ? -35.984 -22.799 -67.272 1.00 48.33 ? 36  LEU   B CD1 1 
ATOM   3336 C CD2 . LEU   B 1 36  ? -38.153 -21.706 -67.888 1.00 51.42 ? 36  LEU   B CD2 1 
ATOM   3337 N N   . GLU   B 1 37  ? -34.527 -18.277 -67.940 1.00 48.13 ? 37  GLU   B N   1 
ATOM   3338 C CA  . GLU   B 1 37  ? -33.865 -17.721 -69.116 1.00 48.90 ? 37  GLU   B CA  1 
ATOM   3339 C C   . GLU   B 1 37  ? -32.355 -17.677 -68.924 1.00 47.74 ? 37  GLU   B C   1 
ATOM   3340 O O   . GLU   B 1 37  ? -31.596 -18.024 -69.837 1.00 45.40 ? 37  GLU   B O   1 
ATOM   3341 C CB  . GLU   B 1 37  ? -34.412 -16.326 -69.423 1.00 50.29 ? 37  GLU   B CB  1 
ATOM   3342 C CG  . GLU   B 1 37  ? -35.715 -16.326 -70.207 1.00 53.04 ? 37  GLU   B CG  1 
ATOM   3343 C CD  . GLU   B 1 37  ? -36.339 -14.949 -70.277 1.00 54.41 ? 37  GLU   B CD  1 
ATOM   3344 O OE1 . GLU   B 1 37  ? -35.912 -14.066 -69.505 1.00 53.57 ? 37  GLU   B OE1 1 
ATOM   3345 O OE2 . GLU   B 1 37  ? -37.253 -14.747 -71.104 1.00 58.65 ? 37  GLU   B OE2 1 
ATOM   3346 N N   . ALA   B 1 38  ? -31.898 -17.258 -67.741 1.00 47.75 ? 38  ALA   B N   1 
ATOM   3347 C CA  . ALA   B 1 38  ? -30.467 -17.278 -67.461 1.00 46.00 ? 38  ALA   B CA  1 
ATOM   3348 C C   . ALA   B 1 38  ? -29.919 -18.699 -67.460 1.00 44.09 ? 38  ALA   B C   1 
ATOM   3349 O O   . ALA   B 1 38  ? -28.763 -18.920 -67.839 1.00 41.06 ? 38  ALA   B O   1 
ATOM   3350 C CB  . ALA   B 1 38  ? -30.182 -16.596 -66.124 1.00 46.26 ? 38  ALA   B CB  1 
ATOM   3351 N N   . CYS   B 1 39  ? -30.731 -19.672 -67.040 1.00 45.37 ? 39  CYS   B N   1 
ATOM   3352 C CA  . CYS   B 1 39  ? -30.312 -21.069 -67.095 1.00 45.64 ? 39  CYS   B CA  1 
ATOM   3353 C C   . CYS   B 1 39  ? -30.225 -21.554 -68.537 1.00 46.43 ? 39  CYS   B C   1 
ATOM   3354 O O   . CYS   B 1 39  ? -29.256 -22.219 -68.922 1.00 47.48 ? 39  CYS   B O   1 
ATOM   3355 C CB  . CYS   B 1 39  ? -31.282 -21.934 -66.289 1.00 42.37 ? 39  CYS   B CB  1 
ATOM   3356 S SG  . CYS   B 1 39  ? -30.954 -23.709 -66.340 1.00 48.86 ? 39  CYS   B SG  1 
ATOM   3357 N N   . ASP   B 1 40  ? -31.235 -21.229 -69.350 1.00 47.66 ? 40  ASP   B N   1 
ATOM   3358 C CA  . ASP   B 1 40  ? -31.217 -21.639 -70.750 1.00 45.08 ? 40  ASP   B CA  1 
ATOM   3359 C C   . ASP   B 1 40  ? -30.068 -20.983 -71.503 1.00 44.71 ? 40  ASP   B C   1 
ATOM   3360 O O   . ASP   B 1 40  ? -29.446 -21.609 -72.369 1.00 46.32 ? 40  ASP   B O   1 
ATOM   3361 C CB  . ASP   B 1 40  ? -32.551 -21.298 -71.414 1.00 45.66 ? 40  ASP   B CB  1 
ATOM   3362 C CG  . ASP   B 1 40  ? -33.689 -22.162 -70.915 1.00 52.35 ? 40  ASP   B CG  1 
ATOM   3363 O OD1 . ASP   B 1 40  ? -33.444 -23.341 -70.586 1.00 51.52 ? 40  ASP   B OD1 1 
ATOM   3364 O OD2 . ASP   B 1 40  ? -34.831 -21.663 -70.860 1.00 56.15 ? 40  ASP   B OD2 1 
ATOM   3365 N N   . ALA   B 1 41  ? -29.770 -19.721 -71.185 1.00 41.61 ? 41  ALA   B N   1 
ATOM   3366 C CA  . ALA   B 1 41  ? -28.699 -19.014 -71.880 1.00 43.33 ? 41  ALA   B CA  1 
ATOM   3367 C C   . ALA   B 1 41  ? -27.343 -19.655 -71.610 1.00 45.04 ? 41  ALA   B C   1 
ATOM   3368 O O   . ALA   B 1 41  ? -26.491 -19.719 -72.504 1.00 45.68 ? 41  ALA   B O   1 
ATOM   3369 C CB  . ALA   B 1 41  ? -28.688 -17.541 -71.470 1.00 44.44 ? 41  ALA   B CB  1 
ATOM   3370 N N   . ALA   B 1 42  ? -27.121 -20.135 -70.384 1.00 43.99 ? 42  ALA   B N   1 
ATOM   3371 C CA  . ALA   B 1 42  ? -25.855 -20.791 -70.074 1.00 44.85 ? 42  ALA   B CA  1 
ATOM   3372 C C   . ALA   B 1 42  ? -25.776 -22.166 -70.726 1.00 43.51 ? 42  ALA   B C   1 
ATOM   3373 O O   . ALA   B 1 42  ? -24.704 -22.581 -71.182 1.00 42.94 ? 42  ALA   B O   1 
ATOM   3374 C CB  . ALA   B 1 42  ? -25.672 -20.898 -68.561 1.00 43.05 ? 42  ALA   B CB  1 
ATOM   3375 N N   . ILE   B 1 43  ? -26.898 -22.890 -70.768 1.00 44.10 ? 43  ILE   B N   1 
ATOM   3376 C CA  . ILE   B 1 43  ? -26.933 -24.179 -71.457 1.00 45.19 ? 43  ILE   B CA  1 
ATOM   3377 C C   . ILE   B 1 43  ? -26.585 -24.002 -72.930 1.00 47.85 ? 43  ILE   B C   1 
ATOM   3378 O O   . ILE   B 1 43  ? -25.893 -24.836 -73.527 1.00 50.82 ? 43  ILE   B O   1 
ATOM   3379 C CB  . ILE   B 1 43  ? -28.311 -24.842 -71.274 1.00 45.33 ? 43  ILE   B CB  1 
ATOM   3380 C CG1 . ILE   B 1 43  ? -28.500 -25.277 -69.819 1.00 46.83 ? 43  ILE   B CG1 1 
ATOM   3381 C CG2 . ILE   B 1 43  ? -28.482 -26.021 -72.229 1.00 47.67 ? 43  ILE   B CG2 1 
ATOM   3382 C CD1 . ILE   B 1 43  ? -29.874 -25.829 -69.519 1.00 47.16 ? 43  ILE   B CD1 1 
ATOM   3383 N N   . ALA   B 1 44  ? -27.052 -22.907 -73.535 1.00 47.84 ? 44  ALA   B N   1 
ATOM   3384 C CA  . ALA   B 1 44  ? -26.726 -22.627 -74.929 1.00 49.18 ? 44  ALA   B CA  1 
ATOM   3385 C C   . ALA   B 1 44  ? -25.243 -22.321 -75.100 1.00 48.36 ? 44  ALA   B C   1 
ATOM   3386 O O   . ALA   B 1 44  ? -24.603 -22.830 -76.026 1.00 50.15 ? 44  ALA   B O   1 
ATOM   3387 C CB  . ALA   B 1 44  ? -27.574 -21.465 -75.445 1.00 46.23 ? 44  ALA   B CB  1 
ATOM   3388 N N   . ARG   B 1 45  ? -24.681 -21.491 -74.218 1.00 43.68 ? 45  ARG   B N   1 
ATOM   3389 C CA  . ARG   B 1 45  ? -23.256 -21.184 -74.295 1.00 45.00 ? 45  ARG   B CA  1 
ATOM   3390 C C   . ARG   B 1 45  ? -22.410 -22.445 -74.174 1.00 44.98 ? 45  ARG   B C   1 
ATOM   3391 O O   . ARG   B 1 45  ? -21.362 -22.561 -74.818 1.00 45.25 ? 45  ARG   B O   1 
ATOM   3392 C CB  . ARG   B 1 45  ? -22.870 -20.177 -73.211 1.00 46.79 ? 45  ARG   B CB  1 
ATOM   3393 C CG  . ARG   B 1 45  ? -23.451 -18.787 -73.408 1.00 47.96 ? 45  ARG   B CG  1 
ATOM   3394 C CD  . ARG   B 1 45  ? -22.764 -17.778 -72.503 1.00 46.63 ? 45  ARG   B CD  1 
ATOM   3395 N NE  . ARG   B 1 45  ? -22.798 -18.186 -71.103 1.00 45.35 ? 45  ARG   B NE  1 
ATOM   3396 C CZ  . ARG   B 1 45  ? -23.754 -17.857 -70.246 1.00 46.61 ? 45  ARG   B CZ  1 
ATOM   3397 N NH1 . ARG   B 1 45  ? -24.786 -17.116 -70.613 1.00 46.07 ? 45  ARG   B NH1 1 
ATOM   3398 N NH2 . ARG   B 1 45  ? -23.672 -18.283 -68.988 1.00 43.58 ? 45  ARG   B NH2 1 
ATOM   3399 N N   . ILE   B 1 46  ? -22.847 -23.402 -73.354 1.00 45.52 ? 46  ILE   B N   1 
ATOM   3400 C CA  . ILE   B 1 46  ? -22.104 -24.650 -73.204 1.00 48.46 ? 46  ILE   B CA  1 
ATOM   3401 C C   . ILE   B 1 46  ? -22.171 -25.466 -74.489 1.00 48.99 ? 46  ILE   B C   1 
ATOM   3402 O O   . ILE   B 1 46  ? -21.141 -25.853 -75.053 1.00 49.24 ? 46  ILE   B O   1 
ATOM   3403 C CB  . ILE   B 1 46  ? -22.635 -25.448 -72.000 1.00 47.69 ? 46  ILE   B CB  1 
ATOM   3404 C CG1 . ILE   B 1 46  ? -22.296 -24.731 -70.691 1.00 45.89 ? 46  ILE   B CG1 1 
ATOM   3405 C CG2 . ILE   B 1 46  ? -22.082 -26.864 -72.012 1.00 46.15 ? 46  ILE   B CG2 1 
ATOM   3406 C CD1 . ILE   B 1 46  ? -22.830 -25.433 -69.456 1.00 47.20 ? 46  ILE   B CD1 1 
ATOM   3407 N N   . GLU   B 1 47  ? -23.387 -25.727 -74.979 1.00 48.36 ? 47  GLU   B N   1 
ATOM   3408 C CA  . GLU   B 1 47  ? -23.556 -26.520 -76.193 1.00 50.99 ? 47  GLU   B CA  1 
ATOM   3409 C C   . GLU   B 1 47  ? -22.964 -25.832 -77.416 1.00 49.89 ? 47  GLU   B C   1 
ATOM   3410 O O   . GLU   B 1 47  ? -22.702 -26.497 -78.425 1.00 52.38 ? 47  GLU   B O   1 
ATOM   3411 C CB  . GLU   B 1 47  ? -25.041 -26.818 -76.421 1.00 50.77 ? 47  GLU   B CB  1 
ATOM   3412 C CG  . GLU   B 1 47  ? -25.664 -27.687 -75.331 1.00 52.66 ? 47  GLU   B CG  1 
ATOM   3413 C CD  . GLU   B 1 47  ? -27.171 -27.791 -75.440 1.00 56.97 ? 47  GLU   B CD  1 
ATOM   3414 O OE1 . GLU   B 1 47  ? -27.772 -27.022 -76.214 1.00 56.38 ? 47  GLU   B OE1 1 
ATOM   3415 O OE2 . GLU   B 1 47  ? -27.756 -28.642 -74.743 1.00 52.92 ? 47  GLU   B OE2 1 
ATOM   3416 N N   . GLN   B 1 48  ? -22.749 -24.518 -77.356 1.00 50.68 ? 48  GLN   B N   1 
ATOM   3417 C CA  . GLN   B 1 48  ? -22.144 -23.809 -78.475 1.00 49.81 ? 48  GLN   B CA  1 
ATOM   3418 C C   . GLN   B 1 48  ? -20.627 -23.745 -78.387 1.00 48.20 ? 48  GLN   B C   1 
ATOM   3419 O O   . GLN   B 1 48  ? -19.965 -23.608 -79.421 1.00 48.17 ? 48  GLN   B O   1 
ATOM   3420 C CB  . GLN   B 1 48  ? -22.700 -22.385 -78.567 1.00 50.40 ? 48  GLN   B CB  1 
ATOM   3421 C CG  . GLN   B 1 48  ? -23.863 -22.223 -79.538 1.00 56.47 ? 48  GLN   B CG  1 
ATOM   3422 C CD  . GLN   B 1 48  ? -25.187 -22.026 -78.836 1.00 63.83 ? 48  GLN   B CD  1 
ATOM   3423 O OE1 . GLN   B 1 48  ? -25.902 -22.986 -78.557 1.00 63.34 ? 48  GLN   B OE1 1 
ATOM   3424 N NE2 . GLN   B 1 48  ? -25.521 -20.777 -78.542 1.00 63.44 ? 48  GLN   B NE2 1 
ATOM   3425 N N   . ARG   B 1 49  ? -20.058 -23.850 -77.183 1.00 50.38 ? 49  ARG   B N   1 
ATOM   3426 C CA  . ARG   B 1 49  ? -18.639 -23.603 -76.975 1.00 48.73 ? 49  ARG   B CA  1 
ATOM   3427 C C   . ARG   B 1 49  ? -17.857 -24.787 -76.419 1.00 46.59 ? 49  ARG   B C   1 
ATOM   3428 O O   . ARG   B 1 49  ? -16.625 -24.780 -76.509 1.00 48.26 ? 49  ARG   B O   1 
ATOM   3429 C CB  . ARG   B 1 49  ? -18.443 -22.404 -76.033 1.00 46.79 ? 49  ARG   B CB  1 
ATOM   3430 C CG  . ARG   B 1 49  ? -19.076 -21.108 -76.522 1.00 47.96 ? 49  ARG   B CG  1 
ATOM   3431 C CD  . ARG   B 1 49  ? -18.959 -20.003 -75.481 1.00 45.53 ? 49  ARG   B CD  1 
ATOM   3432 N NE  . ARG   B 1 49  ? -19.788 -18.853 -75.825 1.00 47.02 ? 49  ARG   B NE  1 
ATOM   3433 C CZ  . ARG   B 1 49  ? -19.847 -17.731 -75.121 1.00 47.51 ? 49  ARG   B CZ  1 
ATOM   3434 N NH1 . ARG   B 1 49  ? -19.124 -17.561 -74.026 1.00 47.67 ? 49  ARG   B NH1 1 
ATOM   3435 N NH2 . ARG   B 1 49  ? -20.649 -16.752 -75.529 1.00 46.84 ? 49  ARG   B NH2 1 
ATOM   3436 N N   . ASP   B 1 50  ? -18.515 -25.795 -75.848 1.00 46.79 ? 50  ASP   B N   1 
ATOM   3437 C CA  . ASP   B 1 50  ? -17.800 -26.888 -75.196 1.00 47.64 ? 50  ASP   B CA  1 
ATOM   3438 C C   . ASP   B 1 50  ? -17.337 -27.975 -76.159 1.00 46.61 ? 50  ASP   B C   1 
ATOM   3439 O O   . ASP   B 1 50  ? -16.673 -28.921 -75.720 1.00 45.79 ? 50  ASP   B O   1 
ATOM   3440 C CB  . ASP   B 1 50  ? -18.670 -27.525 -74.104 1.00 44.41 ? 50  ASP   B CB  1 
ATOM   3441 C CG  . ASP   B 1 50  ? -17.845 -28.174 -73.006 1.00 45.66 ? 50  ASP   B CG  1 
ATOM   3442 O OD1 . ASP   B 1 50  ? -16.673 -27.778 -72.830 1.00 43.55 ? 50  ASP   B OD1 1 
ATOM   3443 O OD2 . ASP   B 1 50  ? -18.363 -29.079 -72.321 1.00 48.94 ? 50  ASP   B OD2 1 
ATOM   3444 N N   . GLY   B 1 51  ? -17.670 -27.869 -77.443 1.00 48.67 ? 51  GLY   B N   1 
ATOM   3445 C CA  . GLY   B 1 51  ? -17.258 -28.841 -78.429 1.00 47.13 ? 51  GLY   B CA  1 
ATOM   3446 C C   . GLY   B 1 51  ? -15.761 -29.076 -78.433 1.00 46.46 ? 51  GLY   B C   1 
ATOM   3447 O O   . GLY   B 1 51  ? -15.281 -30.165 -78.104 1.00 47.94 ? 51  GLY   B O   1 
ATOM   3448 N N   . PRO   B 1 52  ? -14.987 -28.050 -78.805 1.00 43.48 ? 52  PRO   B N   1 
ATOM   3449 C CA  . PRO   B 1 52  ? -13.524 -28.183 -78.781 1.00 43.10 ? 52  PRO   B CA  1 
ATOM   3450 C C   . PRO   B 1 52  ? -12.904 -28.037 -77.400 1.00 46.66 ? 52  PRO   B C   1 
ATOM   3451 O O   . PRO   B 1 52  ? -11.690 -28.252 -77.266 1.00 46.34 ? 52  PRO   B O   1 
ATOM   3452 C CB  . PRO   B 1 52  ? -13.061 -27.049 -79.704 1.00 44.53 ? 52  PRO   B CB  1 
ATOM   3453 C CG  . PRO   B 1 52  ? -14.119 -26.015 -79.559 1.00 43.82 ? 52  PRO   B CG  1 
ATOM   3454 C CD  . PRO   B 1 52  ? -15.413 -26.770 -79.397 1.00 42.74 ? 52  PRO   B CD  1 
ATOM   3455 N N   . ILE   B 1 53  ? -13.681 -27.674 -76.383 1.00 48.25 ? 53  ILE   B N   1 
ATOM   3456 C CA  . ILE   B 1 53  ? -13.139 -27.459 -75.043 1.00 44.31 ? 53  ILE   B CA  1 
ATOM   3457 C C   . ILE   B 1 53  ? -13.257 -28.713 -74.187 1.00 43.80 ? 53  ILE   B C   1 
ATOM   3458 O O   . ILE   B 1 53  ? -12.273 -29.166 -73.597 1.00 44.31 ? 53  ILE   B O   1 
ATOM   3459 C CB  . ILE   B 1 53  ? -13.842 -26.256 -74.375 1.00 43.85 ? 53  ILE   B CB  1 
ATOM   3460 C CG1 . ILE   B 1 53  ? -13.691 -24.995 -75.233 1.00 44.64 ? 53  ILE   B CG1 1 
ATOM   3461 C CG2 . ILE   B 1 53  ? -13.289 -26.026 -72.973 1.00 42.01 ? 53  ILE   B CG2 1 
ATOM   3462 C CD1 . ILE   B 1 53  ? -12.259 -24.544 -75.422 1.00 45.24 ? 53  ILE   B CD1 1 
ATOM   3463 N N   . ASN   B 1 54  ? -14.461 -29.284 -74.109 1.00 43.95 ? 54  ASN   B N   1 
ATOM   3464 C CA  . ASN   B 1 54  ? -14.746 -30.463 -73.289 1.00 42.34 ? 54  ASN   B CA  1 
ATOM   3465 C C   . ASN   B 1 54  ? -14.425 -30.188 -71.817 1.00 44.39 ? 54  ASN   B C   1 
ATOM   3466 O O   . ASN   B 1 54  ? -13.571 -30.829 -71.200 1.00 42.15 ? 54  ASN   B O   1 
ATOM   3467 C CB  . ASN   B 1 54  ? -13.992 -31.695 -73.804 1.00 41.72 ? 54  ASN   B CB  1 
ATOM   3468 C CG  . ASN   B 1 54  ? -14.571 -32.993 -73.275 1.00 42.15 ? 54  ASN   B CG  1 
ATOM   3469 O OD1 . ASN   B 1 54  ? -15.787 -33.129 -73.133 1.00 44.36 ? 54  ASN   B OD1 1 
ATOM   3470 N ND2 . ASN   B 1 54  ? -13.704 -33.949 -72.968 1.00 38.35 ? 54  ASN   B ND2 1 
ATOM   3471 N N   . ALA   B 1 55  ? -15.135 -29.208 -71.260 1.00 44.96 ? 55  ALA   B N   1 
ATOM   3472 C CA  . ALA   B 1 55  ? -14.966 -28.809 -69.868 1.00 43.55 ? 55  ALA   B CA  1 
ATOM   3473 C C   . ALA   B 1 55  ? -16.110 -29.288 -68.983 1.00 42.45 ? 55  ALA   B C   1 
ATOM   3474 O O   . ALA   B 1 55  ? -15.872 -29.899 -67.938 1.00 42.46 ? 55  ALA   B O   1 
ATOM   3475 C CB  . ALA   B 1 55  ? -14.830 -27.284 -69.771 1.00 41.89 ? 55  ALA   B CB  1 
ATOM   3476 N N   . VAL   B 1 56  ? -17.351 -29.029 -69.391 1.00 44.42 ? 56  VAL   B N   1 
ATOM   3477 C CA  . VAL   B 1 56  ? -18.534 -29.442 -68.633 1.00 41.55 ? 56  VAL   B CA  1 
ATOM   3478 C C   . VAL   B 1 56  ? -18.880 -30.848 -69.114 1.00 42.52 ? 56  VAL   B C   1 
ATOM   3479 O O   . VAL   B 1 56  ? -19.618 -31.038 -70.081 1.00 42.53 ? 56  VAL   B O   1 
ATOM   3480 C CB  . VAL   B 1 56  ? -19.692 -28.464 -68.804 1.00 41.44 ? 56  VAL   B CB  1 
ATOM   3481 C CG1 . VAL   B 1 56  ? -20.835 -28.828 -67.871 1.00 41.70 ? 56  VAL   B CG1 1 
ATOM   3482 C CG2 . VAL   B 1 56  ? -19.219 -27.040 -68.557 1.00 40.62 ? 56  VAL   B CG2 1 
ATOM   3483 N N   . VAL   B 1 57  ? -18.339 -31.848 -68.419 1.00 42.63 ? 57  VAL   B N   1 
ATOM   3484 C CA  . VAL   B 1 57  ? -18.453 -33.235 -68.851 1.00 41.53 ? 57  VAL   B CA  1 
ATOM   3485 C C   . VAL   B 1 57  ? -19.618 -33.979 -68.204 1.00 41.88 ? 57  VAL   B C   1 
ATOM   3486 O O   . VAL   B 1 57  ? -20.037 -35.022 -68.730 1.00 43.26 ? 57  VAL   B O   1 
ATOM   3487 C CB  . VAL   B 1 57  ? -17.134 -33.985 -68.581 1.00 40.56 ? 57  VAL   B CB  1 
ATOM   3488 C CG1 . VAL   B 1 57  ? -16.002 -33.349 -69.366 1.00 42.36 ? 57  VAL   B CG1 1 
ATOM   3489 C CG2 . VAL   B 1 57  ? -16.820 -33.980 -67.095 1.00 42.49 ? 57  VAL   B CG2 1 
ATOM   3490 N N   . VAL   B 1 58  ? -20.137 -33.495 -67.080 1.00 42.14 ? 58  VAL   B N   1 
ATOM   3491 C CA  . VAL   B 1 58  ? -21.326 -34.057 -66.445 1.00 42.85 ? 58  VAL   B CA  1 
ATOM   3492 C C   . VAL   B 1 58  ? -22.419 -33.005 -66.519 1.00 42.04 ? 58  VAL   B C   1 
ATOM   3493 O O   . VAL   B 1 58  ? -22.232 -31.877 -66.047 1.00 44.98 ? 58  VAL   B O   1 
ATOM   3494 C CB  . VAL   B 1 58  ? -21.068 -34.479 -64.990 1.00 44.81 ? 58  VAL   B CB  1 
ATOM   3495 C CG1 . VAL   B 1 58  ? -22.365 -34.956 -64.342 1.00 42.59 ? 58  VAL   B CG1 1 
ATOM   3496 C CG2 . VAL   B 1 58  ? -20.009 -35.565 -64.930 1.00 42.89 ? 58  VAL   B CG2 1 
ATOM   3497 N N   . ARG   B 1 59  ? -23.556 -33.367 -67.107 1.00 41.36 ? 59  ARG   B N   1 
ATOM   3498 C CA  . ARG   B 1 59  ? -24.609 -32.411 -67.414 1.00 47.68 ? 59  ARG   B CA  1 
ATOM   3499 C C   . ARG   B 1 59  ? -25.911 -32.822 -66.740 1.00 46.76 ? 59  ARG   B C   1 
ATOM   3500 O O   . ARG   B 1 59  ? -26.321 -33.985 -66.819 1.00 46.41 ? 59  ARG   B O   1 
ATOM   3501 C CB  . ARG   B 1 59  ? -24.790 -32.281 -68.928 1.00 43.80 ? 59  ARG   B CB  1 
ATOM   3502 C CG  . ARG   B 1 59  ? -23.487 -31.951 -69.638 1.00 45.34 ? 59  ARG   B CG  1 
ATOM   3503 C CD  . ARG   B 1 59  ? -23.683 -31.470 -71.065 1.00 43.95 ? 59  ARG   B CD  1 
ATOM   3504 N NE  . ARG   B 1 59  ? -22.421 -31.012 -71.633 1.00 45.91 ? 59  ARG   B NE  1 
ATOM   3505 C CZ  . ARG   B 1 59  ? -22.280 -30.501 -72.847 1.00 46.75 ? 59  ARG   B CZ  1 
ATOM   3506 N NH1 . ARG   B 1 59  ? -23.311 -30.369 -73.663 1.00 45.14 ? 59  ARG   B NH1 1 
ATOM   3507 N NH2 . ARG   B 1 59  ? -21.074 -30.114 -73.252 1.00 42.55 ? 59  ARG   B NH2 1 
ATOM   3508 N N   . ASP   B 1 60  ? -26.553 -31.858 -66.085 1.00 47.79 ? 60  ASP   B N   1 
ATOM   3509 C CA  . ASP   B 1 60  ? -27.787 -32.046 -65.331 1.00 50.05 ? 60  ASP   B CA  1 
ATOM   3510 C C   . ASP   B 1 60  ? -28.813 -31.002 -65.752 1.00 49.16 ? 60  ASP   B C   1 
ATOM   3511 O O   . ASP   B 1 60  ? -29.462 -30.354 -64.929 1.00 48.86 ? 60  ASP   B O   1 
ATOM   3512 C CB  . ASP   B 1 60  ? -27.505 -31.971 -63.832 1.00 45.66 ? 60  ASP   B CB  1 
ATOM   3513 C CG  . ASP   B 1 60  ? -28.525 -32.730 -63.004 1.00 50.55 ? 60  ASP   B CG  1 
ATOM   3514 O OD1 . ASP   B 1 60  ? -29.432 -33.350 -63.596 1.00 54.74 ? 60  ASP   B OD1 1 
ATOM   3515 O OD2 . ASP   B 1 60  ? -28.415 -32.710 -61.761 1.00 53.87 ? 60  ASP   B OD2 1 
ATOM   3516 N N   . PHE   B 1 61  ? -28.975 -30.843 -67.068 1.00 50.56 ? 61  PHE   B N   1 
ATOM   3517 C CA  . PHE   B 1 61  ? -29.746 -29.724 -67.601 1.00 48.11 ? 61  PHE   B CA  1 
ATOM   3518 C C   . PHE   B 1 61  ? -31.229 -29.835 -67.274 1.00 51.35 ? 61  PHE   B C   1 
ATOM   3519 O O   . PHE   B 1 61  ? -31.889 -28.811 -67.064 1.00 53.33 ? 61  PHE   B O   1 
ATOM   3520 C CB  . PHE   B 1 61  ? -29.550 -29.623 -69.115 1.00 49.83 ? 61  PHE   B CB  1 
ATOM   3521 C CG  . PHE   B 1 61  ? -28.155 -29.236 -69.524 1.00 49.98 ? 61  PHE   B CG  1 
ATOM   3522 C CD1 . PHE   B 1 61  ? -27.263 -28.712 -68.600 1.00 48.01 ? 61  PHE   B CD1 1 
ATOM   3523 C CD2 . PHE   B 1 61  ? -27.738 -29.389 -70.836 1.00 46.27 ? 61  PHE   B CD2 1 
ATOM   3524 C CE1 . PHE   B 1 61  ? -25.980 -28.356 -68.975 1.00 48.11 ? 61  PHE   B CE1 1 
ATOM   3525 C CE2 . PHE   B 1 61  ? -26.456 -29.029 -71.221 1.00 43.31 ? 61  PHE   B CE2 1 
ATOM   3526 C CZ  . PHE   B 1 61  ? -25.575 -28.514 -70.287 1.00 47.55 ? 61  PHE   B CZ  1 
ATOM   3527 N N   . ASP   B 1 62  ? -31.774 -31.052 -67.230 1.00 53.24 ? 62  ASP   B N   1 
ATOM   3528 C CA  . ASP   B 1 62  ? -33.199 -31.211 -66.954 1.00 52.25 ? 62  ASP   B CA  1 
ATOM   3529 C C   . ASP   B 1 62  ? -33.542 -30.744 -65.544 1.00 53.27 ? 62  ASP   B C   1 
ATOM   3530 O O   . ASP   B 1 62  ? -34.487 -29.971 -65.348 1.00 52.74 ? 62  ASP   B O   1 
ATOM   3531 C CB  . ASP   B 1 62  ? -33.618 -32.669 -67.158 1.00 55.79 ? 62  ASP   B CB  1 
ATOM   3532 C CG  . ASP   B 1 62  ? -33.460 -33.126 -68.597 1.00 62.46 ? 62  ASP   B CG  1 
ATOM   3533 O OD1 . ASP   B 1 62  ? -33.768 -32.334 -69.511 1.00 66.84 ? 62  ASP   B OD1 1 
ATOM   3534 O OD2 . ASP   B 1 62  ? -33.028 -34.277 -68.814 1.00 66.80 ? 62  ASP   B OD2 1 
ATOM   3535 N N   . ARG   B 1 63  ? -32.779 -31.197 -64.546 1.00 53.20 ? 63  ARG   B N   1 
ATOM   3536 C CA  . ARG   B 1 63  ? -33.055 -30.791 -63.172 1.00 49.76 ? 63  ARG   B CA  1 
ATOM   3537 C C   . ARG   B 1 63  ? -32.632 -29.351 -62.911 1.00 48.31 ? 63  ARG   B C   1 
ATOM   3538 O O   . ARG   B 1 63  ? -33.171 -28.706 -62.004 1.00 50.31 ? 63  ARG   B O   1 
ATOM   3539 C CB  . ARG   B 1 63  ? -32.360 -31.733 -62.189 1.00 49.66 ? 63  ARG   B CB  1 
ATOM   3540 C CG  . ARG   B 1 63  ? -32.790 -33.183 -62.323 1.00 50.37 ? 63  ARG   B CG  1 
ATOM   3541 C CD  . ARG   B 1 63  ? -32.390 -33.995 -61.102 1.00 51.09 ? 63  ARG   B CD  1 
ATOM   3542 N NE  . ARG   B 1 63  ? -30.946 -34.032 -60.908 1.00 52.13 ? 63  ARG   B NE  1 
ATOM   3543 C CZ  . ARG   B 1 63  ? -30.347 -34.552 -59.845 1.00 47.57 ? 63  ARG   B CZ  1 
ATOM   3544 N NH1 . ARG   B 1 63  ? -31.042 -35.078 -58.851 1.00 49.05 ? 63  ARG   B NH1 1 
ATOM   3545 N NH2 . ARG   B 1 63  ? -29.019 -34.541 -59.778 1.00 44.93 ? 63  ARG   B NH2 1 
ATOM   3546 N N   . ALA   B 1 64  ? -31.677 -28.832 -63.685 1.00 49.95 ? 64  ALA   B N   1 
ATOM   3547 C CA  . ALA   B 1 64  ? -31.273 -27.438 -63.529 1.00 49.80 ? 64  ALA   B CA  1 
ATOM   3548 C C   . ALA   B 1 64  ? -32.404 -26.492 -63.921 1.00 51.19 ? 64  ALA   B C   1 
ATOM   3549 O O   . ALA   B 1 64  ? -32.648 -25.485 -63.247 1.00 50.78 ? 64  ALA   B O   1 
ATOM   3550 C CB  . ALA   B 1 64  ? -30.021 -27.158 -64.360 1.00 48.42 ? 64  ALA   B CB  1 
ATOM   3551 N N   . ARG   B 1 65  ? -33.105 -26.802 -65.015 1.00 50.47 ? 65  ARG   B N   1 
ATOM   3552 C CA  . ARG   B 1 65  ? -34.209 -25.952 -65.454 1.00 51.31 ? 65  ARG   B CA  1 
ATOM   3553 C C   . ARG   B 1 65  ? -35.353 -25.970 -64.448 1.00 50.73 ? 65  ARG   B C   1 
ATOM   3554 O O   . ARG   B 1 65  ? -35.973 -24.934 -64.183 1.00 49.63 ? 65  ARG   B O   1 
ATOM   3555 C CB  . ARG   B 1 65  ? -34.696 -26.392 -66.838 1.00 49.49 ? 65  ARG   B CB  1 
ATOM   3556 C CG  . ARG   B 1 65  ? -33.631 -26.314 -67.922 1.00 50.96 ? 65  ARG   B CG  1 
ATOM   3557 C CD  . ARG   B 1 65  ? -34.178 -26.708 -69.292 1.00 52.19 ? 65  ARG   B CD  1 
ATOM   3558 N NE  . ARG   B 1 65  ? -34.888 -25.610 -69.940 1.00 57.63 ? 65  ARG   B NE  1 
ATOM   3559 C CZ  . ARG   B 1 65  ? -36.203 -25.441 -69.912 1.00 54.73 ? 65  ARG   B CZ  1 
ATOM   3560 N NH1 . ARG   B 1 65  ? -36.996 -26.292 -69.284 1.00 54.87 ? 65  ARG   B NH1 1 
ATOM   3561 N NH2 . ARG   B 1 65  ? -36.735 -24.394 -70.536 1.00 48.79 ? 65  ARG   B NH2 1 
ATOM   3562 N N   . ASP   B 1 66  ? -35.643 -27.140 -63.872 1.00 50.11 ? 66  ASP   B N   1 
ATOM   3563 C CA  . ASP   B 1 66  ? -36.662 -27.212 -62.830 1.00 52.16 ? 66  ASP   B CA  1 
ATOM   3564 C C   . ASP   B 1 66  ? -36.233 -26.445 -61.585 1.00 50.69 ? 66  ASP   B C   1 
ATOM   3565 O O   . ASP   B 1 66  ? -37.065 -25.820 -60.917 1.00 51.95 ? 66  ASP   B O   1 
ATOM   3566 C CB  . ASP   B 1 66  ? -36.963 -28.671 -62.490 1.00 51.06 ? 66  ASP   B CB  1 
ATOM   3567 C CG  . ASP   B 1 66  ? -37.802 -29.355 -63.551 1.00 57.77 ? 66  ASP   B CG  1 
ATOM   3568 O OD1 . ASP   B 1 66  ? -38.215 -28.674 -64.511 1.00 57.13 ? 66  ASP   B OD1 1 
ATOM   3569 O OD2 . ASP   B 1 66  ? -38.054 -30.571 -63.421 1.00 60.36 ? 66  ASP   B OD2 1 
ATOM   3570 N N   . ALA   B 1 67  ? -34.939 -26.483 -61.256 1.00 49.85 ? 67  ALA   B N   1 
ATOM   3571 C CA  . ALA   B 1 67  ? -34.432 -25.657 -60.165 1.00 49.97 ? 67  ALA   B CA  1 
ATOM   3572 C C   . ALA   B 1 67  ? -34.437 -24.182 -60.540 1.00 50.58 ? 67  ALA   B C   1 
ATOM   3573 O O   . ALA   B 1 67  ? -34.618 -23.321 -59.671 1.00 47.98 ? 67  ALA   B O   1 
ATOM   3574 C CB  . ALA   B 1 67  ? -33.023 -26.104 -59.773 1.00 44.84 ? 67  ALA   B CB  1 
ATOM   3575 N N   . ALA   B 1 68  ? -34.245 -23.873 -61.824 1.00 46.72 ? 68  ALA   B N   1 
ATOM   3576 C CA  . ALA   B 1 68  ? -34.318 -22.487 -62.271 1.00 48.03 ? 68  ALA   B CA  1 
ATOM   3577 C C   . ALA   B 1 68  ? -35.745 -21.962 -62.197 1.00 51.25 ? 68  ALA   B C   1 
ATOM   3578 O O   . ALA   B 1 68  ? -35.969 -20.808 -61.812 1.00 50.39 ? 68  ALA   B O   1 
ATOM   3579 C CB  . ALA   B 1 68  ? -33.771 -22.361 -63.692 1.00 46.06 ? 68  ALA   B CB  1 
ATOM   3580 N N   . LYS   B 1 69  ? -36.725 -22.794 -62.560 1.00 50.78 ? 69  LYS   B N   1 
ATOM   3581 C CA  . LYS   B 1 69  ? -38.121 -22.391 -62.429 1.00 50.31 ? 69  LYS   B CA  1 
ATOM   3582 C C   . LYS   B 1 69  ? -38.501 -22.204 -60.966 1.00 48.96 ? 69  LYS   B C   1 
ATOM   3583 O O   . LYS   B 1 69  ? -39.306 -21.326 -60.634 1.00 51.12 ? 69  LYS   B O   1 
ATOM   3584 C CB  . LYS   B 1 69  ? -39.030 -23.425 -63.091 1.00 50.72 ? 69  LYS   B CB  1 
ATOM   3585 C CG  . LYS   B 1 69  ? -38.834 -23.555 -64.591 1.00 51.30 ? 69  LYS   B CG  1 
ATOM   3586 C CD  . LYS   B 1 69  ? -39.574 -24.766 -65.144 1.00 50.78 ? 69  LYS   B CD  1 
ATOM   3587 C CE  . LYS   B 1 69  ? -39.303 -24.939 -66.633 1.00 57.77 ? 69  LYS   B CE  1 
ATOM   3588 N NZ  . LYS   B 1 69  ? -39.913 -26.184 -67.175 1.00 56.99 ? 69  LYS   B NZ  1 
ATOM   3589 N N   . ALA   B 1 70  ? -37.931 -23.023 -60.077 1.00 51.51 ? 70  ALA   B N   1 
ATOM   3590 C CA  . ALA   B 1 70  ? -38.187 -22.853 -58.651 1.00 47.82 ? 70  ALA   B CA  1 
ATOM   3591 C C   . ALA   B 1 70  ? -37.604 -21.542 -58.143 1.00 48.34 ? 70  ALA   B C   1 
ATOM   3592 O O   . ALA   B 1 70  ? -38.210 -20.873 -57.296 1.00 52.49 ? 70  ALA   B O   1 
ATOM   3593 C CB  . ALA   B 1 70  ? -37.618 -24.035 -57.868 1.00 47.66 ? 70  ALA   B CB  1 
ATOM   3594 N N   . ALA   B 1 71  ? -36.431 -21.156 -58.652 1.00 49.16 ? 71  ALA   B N   1 
ATOM   3595 C CA  . ALA   B 1 71  ? -35.850 -19.874 -58.271 1.00 48.68 ? 71  ALA   B CA  1 
ATOM   3596 C C   . ALA   B 1 71  ? -36.715 -18.715 -58.751 1.00 51.87 ? 71  ALA   B C   1 
ATOM   3597 O O   . ALA   B 1 71  ? -36.889 -17.724 -58.034 1.00 51.82 ? 71  ALA   B O   1 
ATOM   3598 C CB  . ALA   B 1 71  ? -34.432 -19.751 -58.825 1.00 46.31 ? 71  ALA   B CB  1 
ATOM   3599 N N   . ASP   B 1 72  ? -37.270 -18.825 -59.962 1.00 51.38 ? 72  ASP   B N   1 
ATOM   3600 C CA  . ASP   B 1 72  ? -38.167 -17.788 -60.464 1.00 51.42 ? 72  ASP   B CA  1 
ATOM   3601 C C   . ASP   B 1 72  ? -39.398 -17.640 -59.578 1.00 53.21 ? 72  ASP   B C   1 
ATOM   3602 O O   . ASP   B 1 72  ? -39.909 -16.529 -59.395 1.00 53.15 ? 72  ASP   B O   1 
ATOM   3603 C CB  . ASP   B 1 72  ? -38.579 -18.100 -61.903 1.00 50.13 ? 72  ASP   B CB  1 
ATOM   3604 C CG  . ASP   B 1 72  ? -37.550 -17.644 -62.914 1.00 51.88 ? 72  ASP   B CG  1 
ATOM   3605 O OD1 . ASP   B 1 72  ? -36.898 -16.609 -62.665 1.00 48.78 ? 72  ASP   B OD1 1 
ATOM   3606 O OD2 . ASP   B 1 72  ? -37.397 -18.310 -63.957 1.00 53.93 ? 72  ASP   B OD2 1 
ATOM   3607 N N   . ALA   B 1 73  ? -39.888 -18.749 -59.019 1.00 50.50 ? 73  ALA   B N   1 
ATOM   3608 C CA  . ALA   B 1 73  ? -41.016 -18.669 -58.097 1.00 53.34 ? 73  ALA   B CA  1 
ATOM   3609 C C   . ALA   B 1 73  ? -40.630 -17.965 -56.802 1.00 56.37 ? 73  ALA   B C   1 
ATOM   3610 O O   . ALA   B 1 73  ? -41.453 -17.254 -56.216 1.00 56.00 ? 73  ALA   B O   1 
ATOM   3611 C CB  . ALA   B 1 73  ? -41.561 -20.068 -57.807 1.00 51.00 ? 73  ALA   B CB  1 
ATOM   3612 N N   . GLU   B 1 74  ? -39.388 -18.143 -56.346 1.00 55.39 ? 74  GLU   B N   1 
ATOM   3613 C CA  . GLU   B 1 74  ? -38.938 -17.440 -55.149 1.00 55.70 ? 74  GLU   B CA  1 
ATOM   3614 C C   . GLU   B 1 74  ? -38.723 -15.958 -55.432 1.00 56.72 ? 74  GLU   B C   1 
ATOM   3615 O O   . GLU   B 1 74  ? -38.997 -15.109 -54.575 1.00 59.39 ? 74  GLU   B O   1 
ATOM   3616 C CB  . GLU   B 1 74  ? -37.655 -18.078 -54.612 1.00 51.84 ? 74  GLU   B CB  1 
ATOM   3617 C CG  . GLU   B 1 74  ? -37.773 -19.567 -54.315 1.00 54.36 ? 74  GLU   B CG  1 
ATOM   3618 C CD  . GLU   B 1 74  ? -36.501 -20.145 -53.729 1.00 62.02 ? 74  GLU   B CD  1 
ATOM   3619 O OE1 . GLU   B 1 74  ? -36.000 -19.589 -52.730 1.00 57.41 ? 74  GLU   B OE1 1 
ATOM   3620 O OE2 . GLU   B 1 74  ? -35.996 -21.147 -54.273 1.00 67.38 ? 74  GLU   B OE2 1 
ATOM   3621 N N   . ILE   B 1 75  ? -38.228 -15.632 -56.629 1.00 55.91 ? 75  ILE   B N   1 
ATOM   3622 C CA  . ILE   B 1 75  ? -38.091 -14.234 -57.032 1.00 58.26 ? 75  ILE   B CA  1 
ATOM   3623 C C   . ILE   B 1 75  ? -39.453 -13.554 -57.040 1.00 59.21 ? 75  ILE   B C   1 
ATOM   3624 O O   . ILE   B 1 75  ? -39.631 -12.465 -56.480 1.00 61.19 ? 75  ILE   B O   1 
ATOM   3625 C CB  . ILE   B 1 75  ? -37.411 -14.139 -58.410 1.00 56.70 ? 75  ILE   B CB  1 
ATOM   3626 C CG1 . ILE   B 1 75  ? -36.013 -14.754 -58.364 1.00 56.27 ? 75  ILE   B CG1 1 
ATOM   3627 C CG2 . ILE   B 1 75  ? -37.349 -12.692 -58.880 1.00 61.25 ? 75  ILE   B CG2 1 
ATOM   3628 C CD1 . ILE   B 1 75  ? -35.449 -15.078 -59.724 1.00 54.99 ? 75  ILE   B CD1 1 
ATOM   3629 N N   . ALA   B 1 76  ? -40.436 -14.190 -57.682 1.00 58.52 ? 76  ALA   B N   1 
ATOM   3630 C CA  . ALA   B 1 76  ? -41.791 -13.650 -57.691 1.00 59.43 ? 76  ALA   B CA  1 
ATOM   3631 C C   . ALA   B 1 76  ? -42.388 -13.617 -56.291 1.00 58.37 ? 76  ALA   B C   1 
ATOM   3632 O O   . ALA   B 1 76  ? -43.292 -12.818 -56.020 1.00 58.25 ? 76  ALA   B O   1 
ATOM   3633 C CB  . ALA   B 1 76  ? -42.678 -14.473 -58.625 1.00 58.47 ? 76  ALA   B CB  1 
ATOM   3634 N N   . ALA   B 1 77  ? -41.901 -14.471 -55.390 1.00 58.64 ? 77  ALA   B N   1 
ATOM   3635 C CA  . ALA   B 1 77  ? -42.348 -14.460 -54.003 1.00 58.90 ? 77  ALA   B CA  1 
ATOM   3636 C C   . ALA   B 1 77  ? -41.578 -13.470 -53.140 1.00 59.41 ? 77  ALA   B C   1 
ATOM   3637 O O   . ALA   B 1 77  ? -41.749 -13.483 -51.916 1.00 60.63 ? 77  ALA   B O   1 
ATOM   3638 C CB  . ALA   B 1 77  ? -42.240 -15.864 -53.404 1.00 54.12 ? 77  ALA   B CB  1 
ATOM   3639 N N   . ALA   B 1 78  ? -40.737 -12.631 -53.749 1.00 61.30 ? 78  ALA   B N   1 
ATOM   3640 C CA  . ALA   B 1 78  ? -39.955 -11.556 -53.131 1.00 60.14 ? 78  ALA   B CA  1 
ATOM   3641 C C   . ALA   B 1 78  ? -38.797 -12.059 -52.278 1.00 62.85 ? 78  ALA   B C   1 
ATOM   3642 O O   . ALA   B 1 78  ? -38.196 -11.258 -51.546 1.00 63.76 ? 78  ALA   B O   1 
ATOM   3643 C CB  . ALA   B 1 78  ? -40.820 -10.618 -52.282 1.00 54.50 ? 78  ALA   B CB  1 
ATOM   3644 N N   . VAL   B 1 79  ? -38.456 -13.347 -52.339 1.00 62.30 ? 79  VAL   B N   1 
ATOM   3645 C CA  . VAL   B 1 79  ? -37.278 -13.836 -51.634 1.00 59.95 ? 79  VAL   B CA  1 
ATOM   3646 C C   . VAL   B 1 79  ? -36.025 -13.367 -52.363 1.00 58.88 ? 79  VAL   B C   1 
ATOM   3647 O O   . VAL   B 1 79  ? -35.952 -13.405 -53.599 1.00 60.00 ? 79  VAL   B O   1 
ATOM   3648 C CB  . VAL   B 1 79  ? -37.316 -15.370 -51.516 1.00 59.39 ? 79  VAL   B CB  1 
ATOM   3649 C CG1 . VAL   B 1 79  ? -36.050 -15.890 -50.848 1.00 58.63 ? 79  VAL   B CG1 1 
ATOM   3650 C CG2 . VAL   B 1 79  ? -38.549 -15.811 -50.744 1.00 57.27 ? 79  VAL   B CG2 1 
ATOM   3651 N N   . ARG   B 1 80  ? -35.033 -12.910 -51.600 1.00 59.45 ? 80  ARG   B N   1 
ATOM   3652 C CA  . ARG   B 1 80  ? -33.783 -12.411 -52.161 1.00 59.47 ? 80  ARG   B CA  1 
ATOM   3653 C C   . ARG   B 1 80  ? -32.602 -13.110 -51.506 1.00 57.66 ? 80  ARG   B C   1 
ATOM   3654 O O   . ARG   B 1 80  ? -32.474 -13.110 -50.277 1.00 54.66 ? 80  ARG   B O   1 
ATOM   3655 C CB  . ARG   B 1 80  ? -33.661 -10.894 -51.988 1.00 64.22 ? 80  ARG   B CB  1 
ATOM   3656 C CG  . ARG   B 1 80  ? -34.513 -10.101 -52.963 1.00 63.24 ? 80  ARG   B CG  1 
ATOM   3657 C CD  . ARG   B 1 80  ? -34.168 -10.465 -54.398 1.00 64.81 ? 80  ARG   B CD  1 
ATOM   3658 N NE  . ARG   B 1 80  ? -35.061 -9.827  -55.357 1.00 65.09 ? 80  ARG   B NE  1 
ATOM   3659 C CZ  . ARG   B 1 80  ? -36.208 -10.345 -55.774 1.00 65.78 ? 80  ARG   B CZ  1 
ATOM   3660 N NH1 . ARG   B 1 80  ? -36.643 -11.509 -55.325 1.00 65.08 ? 80  ARG   B NH1 1 
ATOM   3661 N NH2 . ARG   B 1 80  ? -36.938 -9.675  -56.662 1.00 59.48 ? 80  ARG   B NH2 1 
ATOM   3662 N N   . LYS   B 1 81  ? -31.742 -13.698 -52.333 1.00 53.50 ? 81  LYS   B N   1 
ATOM   3663 C CA  . LYS   B 1 81  ? -30.533 -14.389 -51.916 1.00 51.55 ? 81  LYS   B CA  1 
ATOM   3664 C C   . LYS   B 1 81  ? -29.403 -13.964 -52.842 1.00 50.15 ? 81  LYS   B C   1 
ATOM   3665 O O   . LYS   B 1 81  ? -29.652 -13.619 -54.004 1.00 52.89 ? 81  LYS   B O   1 
ATOM   3666 C CB  . LYS   B 1 81  ? -30.721 -15.914 -51.957 1.00 49.49 ? 81  LYS   B CB  1 
ATOM   3667 C CG  . LYS   B 1 81  ? -31.846 -16.413 -51.060 1.00 52.13 ? 81  LYS   B CG  1 
ATOM   3668 C CD  . LYS   B 1 81  ? -32.084 -17.904 -51.223 1.00 50.20 ? 81  LYS   B CD  1 
ATOM   3669 C CE  . LYS   B 1 81  ? -33.248 -18.372 -50.361 1.00 52.74 ? 81  LYS   B CE  1 
ATOM   3670 N NZ  . LYS   B 1 81  ? -33.477 -19.837 -50.494 1.00 51.69 ? 81  LYS   B NZ  1 
ATOM   3671 N N   . PRO   B 1 82  ? -28.154 -13.975 -52.361 1.00 47.19 ? 82  PRO   B N   1 
ATOM   3672 C CA  . PRO   B 1 82  ? -27.061 -13.369 -53.146 1.00 49.16 ? 82  PRO   B CA  1 
ATOM   3673 C C   . PRO   B 1 82  ? -26.763 -14.065 -54.466 1.00 47.28 ? 82  PRO   B C   1 
ATOM   3674 O O   . PRO   B 1 82  ? -26.125 -13.452 -55.330 1.00 48.77 ? 82  PRO   B O   1 
ATOM   3675 C CB  . PRO   B 1 82  ? -25.859 -13.446 -52.193 1.00 41.92 ? 82  PRO   B CB  1 
ATOM   3676 C CG  . PRO   B 1 82  ? -26.202 -14.540 -51.238 1.00 42.03 ? 82  PRO   B CG  1 
ATOM   3677 C CD  . PRO   B 1 82  ? -27.684 -14.469 -51.055 1.00 44.97 ? 82  PRO   B CD  1 
ATOM   3678 N N   . LEU   B 1 83  ? -27.196 -15.312 -54.659 1.00 45.51 ? 83  LEU   B N   1 
ATOM   3679 C CA  . LEU   B 1 83  ? -26.916 -16.045 -55.889 1.00 46.80 ? 83  LEU   B CA  1 
ATOM   3680 C C   . LEU   B 1 83  ? -28.192 -16.610 -56.498 1.00 46.34 ? 83  LEU   B C   1 
ATOM   3681 O O   . LEU   B 1 83  ? -28.155 -17.636 -57.183 1.00 45.21 ? 83  LEU   B O   1 
ATOM   3682 C CB  . LEU   B 1 83  ? -25.907 -17.166 -55.641 1.00 43.81 ? 83  LEU   B CB  1 
ATOM   3683 C CG  . LEU   B 1 83  ? -24.461 -16.765 -55.353 1.00 45.51 ? 83  LEU   B CG  1 
ATOM   3684 C CD1 . LEU   B 1 83  ? -23.591 -18.005 -55.219 1.00 40.43 ? 83  LEU   B CD1 1 
ATOM   3685 C CD2 . LEU   B 1 83  ? -23.931 -15.851 -56.445 1.00 45.22 ? 83  LEU   B CD2 1 
ATOM   3686 N N   . LEU   B 1 84  ? -29.323 -15.949 -56.264 1.00 46.30 ? 84  LEU   B N   1 
ATOM   3687 C CA  . LEU   B 1 84  ? -30.615 -16.490 -56.671 1.00 48.04 ? 84  LEU   B CA  1 
ATOM   3688 C C   . LEU   B 1 84  ? -30.697 -16.629 -58.187 1.00 47.72 ? 84  LEU   B C   1 
ATOM   3689 O O   . LEU   B 1 84  ? -30.604 -15.636 -58.917 1.00 45.61 ? 84  LEU   B O   1 
ATOM   3690 C CB  . LEU   B 1 84  ? -31.738 -15.591 -56.153 1.00 49.95 ? 84  LEU   B CB  1 
ATOM   3691 C CG  . LEU   B 1 84  ? -33.171 -16.101 -56.298 1.00 52.23 ? 84  LEU   B CG  1 
ATOM   3692 C CD1 . LEU   B 1 84  ? -33.257 -17.571 -55.924 1.00 51.28 ? 84  LEU   B CD1 1 
ATOM   3693 C CD2 . LEU   B 1 84  ? -34.090 -15.277 -55.423 1.00 55.45 ? 84  LEU   B CD2 1 
ATOM   3694 N N   . GLY   B 1 85  ? -30.875 -17.864 -58.655 1.00 47.40 ? 85  GLY   B N   1 
ATOM   3695 C CA  . GLY   B 1 85  ? -31.031 -18.135 -60.069 1.00 45.76 ? 85  GLY   B CA  1 
ATOM   3696 C C   . GLY   B 1 85  ? -29.751 -18.171 -60.870 1.00 45.65 ? 85  GLY   B C   1 
ATOM   3697 O O   . GLY   B 1 85  ? -29.810 -18.320 -62.096 1.00 42.84 ? 85  GLY   B O   1 
ATOM   3698 N N   . VAL   B 1 86  ? -28.597 -18.044 -60.224 1.00 45.47 ? 86  VAL   B N   1 
ATOM   3699 C CA  . VAL   B 1 86  ? -27.313 -18.008 -60.919 1.00 43.92 ? 86  VAL   B CA  1 
ATOM   3700 C C   . VAL   B 1 86  ? -26.914 -19.422 -61.325 1.00 45.18 ? 86  VAL   B C   1 
ATOM   3701 O O   . VAL   B 1 86  ? -26.743 -20.290 -60.458 1.00 43.83 ? 86  VAL   B O   1 
ATOM   3702 C CB  . VAL   B 1 86  ? -26.225 -17.364 -60.047 1.00 41.52 ? 86  VAL   B CB  1 
ATOM   3703 C CG1 . VAL   B 1 86  ? -24.870 -17.443 -60.739 1.00 40.96 ? 86  VAL   B CG1 1 
ATOM   3704 C CG2 . VAL   B 1 86  ? -26.583 -15.927 -59.736 1.00 42.49 ? 86  VAL   B CG2 1 
ATOM   3705 N N   . PRO   B 1 87  ? -26.749 -19.698 -62.618 1.00 43.93 ? 87  PRO   B N   1 
ATOM   3706 C CA  . PRO   B 1 87  ? -26.290 -21.025 -63.041 1.00 43.88 ? 87  PRO   B CA  1 
ATOM   3707 C C   . PRO   B 1 87  ? -24.775 -21.148 -62.962 1.00 43.87 ? 87  PRO   B C   1 
ATOM   3708 O O   . PRO   B 1 87  ? -24.034 -20.212 -63.276 1.00 44.16 ? 87  PRO   B O   1 
ATOM   3709 C CB  . PRO   B 1 87  ? -26.778 -21.113 -64.491 1.00 44.21 ? 87  PRO   B CB  1 
ATOM   3710 C CG  . PRO   B 1 87  ? -26.732 -19.697 -64.966 1.00 45.11 ? 87  PRO   B CG  1 
ATOM   3711 C CD  . PRO   B 1 87  ? -27.059 -18.828 -63.765 1.00 43.68 ? 87  PRO   B CD  1 
ATOM   3712 N N   . MET   B 1 88  ? -24.317 -22.323 -62.538 1.00 41.06 ? 88  MET   B N   1 
ATOM   3713 C CA  . MET   B 1 88  ? -22.895 -22.561 -62.350 1.00 42.20 ? 88  MET   B CA  1 
ATOM   3714 C C   . MET   B 1 88  ? -22.625 -24.053 -62.446 1.00 41.77 ? 88  MET   B C   1 
ATOM   3715 O O   . MET   B 1 88  ? -23.544 -24.866 -62.566 1.00 40.86 ? 88  MET   B O   1 
ATOM   3716 C CB  . MET   B 1 88  ? -22.406 -22.009 -61.006 1.00 45.83 ? 88  MET   B CB  1 
ATOM   3717 C CG  . MET   B 1 88  ? -22.953 -22.754 -59.798 1.00 43.83 ? 88  MET   B CG  1 
ATOM   3718 S SD  . MET   B 1 88  ? -22.236 -22.184 -58.247 1.00 49.86 ? 88  MET   B SD  1 
ATOM   3719 C CE  . MET   B 1 88  ? -22.650 -20.445 -58.316 1.00 48.15 ? 88  MET   B CE  1 
ATOM   3720 N N   . THR   B 1 89  ? -21.344 -24.405 -62.380 1.00 43.67 ? 89  THR   B N   1 
ATOM   3721 C CA  . THR   B 1 89  ? -20.891 -25.783 -62.293 1.00 44.31 ? 89  THR   B CA  1 
ATOM   3722 C C   . THR   B 1 89  ? -19.912 -25.898 -61.133 1.00 44.34 ? 89  THR   B C   1 
ATOM   3723 O O   . THR   B 1 89  ? -19.475 -24.898 -60.557 1.00 43.83 ? 89  THR   B O   1 
ATOM   3724 C CB  . THR   B 1 89  ? -20.223 -26.255 -63.595 1.00 42.97 ? 89  THR   B CB  1 
ATOM   3725 O OG1 . THR   B 1 89  ? -19.105 -25.411 -63.895 1.00 45.22 ? 89  THR   B OG1 1 
ATOM   3726 C CG2 . THR   B 1 89  ? -21.199 -26.213 -64.754 1.00 44.63 ? 89  THR   B CG2 1 
ATOM   3727 N N   . ILE   B 1 90  ? -19.562 -27.135 -60.792 1.00 41.18 ? 90  ILE   B N   1 
ATOM   3728 C CA  . ILE   B 1 90  ? -18.584 -27.395 -59.745 1.00 42.97 ? 90  ILE   B CA  1 
ATOM   3729 C C   . ILE   B 1 90  ? -17.688 -28.538 -60.197 1.00 42.05 ? 90  ILE   B C   1 
ATOM   3730 O O   . ILE   B 1 90  ? -18.061 -29.343 -61.056 1.00 40.23 ? 90  ILE   B O   1 
ATOM   3731 C CB  . ILE   B 1 90  ? -19.257 -27.711 -58.389 1.00 41.20 ? 90  ILE   B CB  1 
ATOM   3732 C CG1 . ILE   B 1 90  ? -18.243 -27.588 -57.245 1.00 41.02 ? 90  ILE   B CG1 1 
ATOM   3733 C CG2 . ILE   B 1 90  ? -19.899 -29.096 -58.410 1.00 41.52 ? 90  ILE   B CG2 1 
ATOM   3734 C CD1 . ILE   B 1 90  ? -18.867 -27.558 -55.874 1.00 40.90 ? 90  ILE   B CD1 1 
ATOM   3735 N N   . LYS   B 1 91  ? -16.487 -28.589 -59.622 1.00 41.87 ? 91  LYS   B N   1 
ATOM   3736 C CA  . LYS   B 1 91  ? -15.551 -29.662 -59.916 1.00 40.85 ? 91  LYS   B CA  1 
ATOM   3737 C C   . LYS   B 1 91  ? -16.211 -31.016 -59.693 1.00 39.46 ? 91  LYS   B C   1 
ATOM   3738 O O   . LYS   B 1 91  ? -16.980 -31.203 -58.746 1.00 40.78 ? 91  LYS   B O   1 
ATOM   3739 C CB  . LYS   B 1 91  ? -14.315 -29.509 -59.034 1.00 41.94 ? 91  LYS   B CB  1 
ATOM   3740 C CG  . LYS   B 1 91  ? -13.186 -30.473 -59.322 1.00 39.94 ? 91  LYS   B CG  1 
ATOM   3741 C CD  . LYS   B 1 91  ? -11.970 -30.096 -58.496 1.00 42.45 ? 91  LYS   B CD  1 
ATOM   3742 C CE  . LYS   B 1 91  ? -10.779 -30.982 -58.796 1.00 41.09 ? 91  LYS   B CE  1 
ATOM   3743 N NZ  . LYS   B 1 91  ? -9.531  -30.402 -58.234 1.00 44.37 ? 91  LYS   B NZ  1 
ATOM   3744 N N   . GLU   B 1 92  ? -15.911 -31.962 -60.588 1.00 40.37 ? 92  GLU   B N   1 
ATOM   3745 C CA  . GLU   B 1 92  ? -16.573 -33.263 -60.557 1.00 40.44 ? 92  GLU   B CA  1 
ATOM   3746 C C   . GLU   B 1 92  ? -16.338 -34.015 -59.254 1.00 42.89 ? 92  GLU   B C   1 
ATOM   3747 O O   . GLU   B 1 92  ? -17.133 -34.900 -58.915 1.00 42.24 ? 92  GLU   B O   1 
ATOM   3748 C CB  . GLU   B 1 92  ? -16.106 -34.113 -61.742 1.00 41.18 ? 92  GLU   B CB  1 
ATOM   3749 C CG  . GLU   B 1 92  ? -17.015 -35.285 -62.074 1.00 42.44 ? 92  GLU   B CG  1 
ATOM   3750 C CD  . GLU   B 1 92  ? -16.496 -36.604 -61.540 1.00 43.32 ? 92  GLU   B CD  1 
ATOM   3751 O OE1 . GLU   B 1 92  ? -15.549 -36.589 -60.727 1.00 43.41 ? 92  GLU   B OE1 1 
ATOM   3752 O OE2 . GLU   B 1 92  ? -17.030 -37.659 -61.943 1.00 43.03 ? 92  GLU   B OE2 1 
ATOM   3753 N N   . SER   B 1 93  ? -15.274 -33.688 -58.516 1.00 43.86 ? 93  SER   B N   1 
ATOM   3754 C CA  . SER   B 1 93  ? -14.978 -34.424 -57.292 1.00 41.14 ? 93  SER   B CA  1 
ATOM   3755 C C   . SER   B 1 93  ? -15.909 -34.043 -56.146 1.00 40.74 ? 93  SER   B C   1 
ATOM   3756 O O   . SER   B 1 93  ? -15.982 -34.775 -55.153 1.00 41.64 ? 93  SER   B O   1 
ATOM   3757 C CB  . SER   B 1 93  ? -13.522 -34.201 -56.888 1.00 40.54 ? 93  SER   B CB  1 
ATOM   3758 O OG  . SER   B 1 93  ? -13.153 -32.839 -57.023 1.00 40.03 ? 93  SER   B OG  1 
ATOM   3759 N N   . PHE   B 1 94  ? -16.613 -32.918 -56.256 1.00 40.06 ? 94  PHE   B N   1 
ATOM   3760 C CA  . PHE   B 1 94  ? -17.622 -32.554 -55.271 1.00 41.98 ? 94  PHE   B CA  1 
ATOM   3761 C C   . PHE   B 1 94  ? -18.902 -33.348 -55.501 1.00 42.07 ? 94  PHE   B C   1 
ATOM   3762 O O   . PHE   B 1 94  ? -19.317 -33.574 -56.641 1.00 44.45 ? 94  PHE   B O   1 
ATOM   3763 C CB  . PHE   B 1 94  ? -17.921 -31.056 -55.332 1.00 41.76 ? 94  PHE   B CB  1 
ATOM   3764 C CG  . PHE   B 1 94  ? -16.775 -30.189 -54.896 1.00 41.15 ? 94  PHE   B CG  1 
ATOM   3765 C CD1 . PHE   B 1 94  ? -15.768 -29.845 -55.784 1.00 40.89 ? 94  PHE   B CD1 1 
ATOM   3766 C CD2 . PHE   B 1 94  ? -16.711 -29.706 -53.600 1.00 43.73 ? 94  PHE   B CD2 1 
ATOM   3767 C CE1 . PHE   B 1 94  ? -14.711 -29.041 -55.384 1.00 41.36 ? 94  PHE   B CE1 1 
ATOM   3768 C CE2 . PHE   B 1 94  ? -15.659 -28.902 -53.192 1.00 43.49 ? 94  PHE   B CE2 1 
ATOM   3769 C CZ  . PHE   B 1 94  ? -14.656 -28.570 -54.085 1.00 42.12 ? 94  PHE   B CZ  1 
ATOM   3770 N N   . ASP   B 1 95  ? -19.532 -33.761 -54.404 1.00 41.61 ? 95  ASP   B N   1 
ATOM   3771 C CA  . ASP   B 1 95  ? -20.759 -34.540 -54.477 1.00 42.57 ? 95  ASP   B CA  1 
ATOM   3772 C C   . ASP   B 1 95  ? -21.958 -33.636 -54.730 1.00 43.52 ? 95  ASP   B C   1 
ATOM   3773 O O   . ASP   B 1 95  ? -22.148 -32.628 -54.042 1.00 43.30 ? 95  ASP   B O   1 
ATOM   3774 C CB  . ASP   B 1 95  ? -20.973 -35.330 -53.186 1.00 43.77 ? 95  ASP   B CB  1 
ATOM   3775 C CG  . ASP   B 1 95  ? -20.244 -36.656 -53.188 1.00 43.51 ? 95  ASP   B CG  1 
ATOM   3776 O OD1 . ASP   B 1 95  ? -19.528 -36.942 -54.168 1.00 41.43 ? 95  ASP   B OD1 1 
ATOM   3777 O OD2 . ASP   B 1 95  ? -20.397 -37.420 -52.212 1.00 42.48 ? 95  ASP   B OD2 1 
ATOM   3778 N N   . ILE   B 1 96  ? -22.759 -33.993 -55.728 1.00 40.90 ? 96  ILE   B N   1 
ATOM   3779 C CA  . ILE   B 1 96  ? -24.080 -33.416 -55.939 1.00 39.09 ? 96  ILE   B CA  1 
ATOM   3780 C C   . ILE   B 1 96  ? -25.075 -34.567 -55.954 1.00 40.91 ? 96  ILE   B C   1 
ATOM   3781 O O   . ILE   B 1 96  ? -24.843 -35.581 -56.625 1.00 41.84 ? 96  ILE   B O   1 
ATOM   3782 C CB  . ILE   B 1 96  ? -24.155 -32.599 -57.244 1.00 43.50 ? 96  ILE   B CB  1 
ATOM   3783 C CG1 . ILE   B 1 96  ? -23.247 -31.370 -57.164 1.00 43.73 ? 96  ILE   B CG1 1 
ATOM   3784 C CG2 . ILE   B 1 96  ? -25.586 -32.176 -57.532 1.00 41.20 ? 96  ILE   B CG2 1 
ATOM   3785 C CD1 . ILE   B 1 96  ? -23.395 -30.426 -58.343 1.00 43.85 ? 96  ILE   B CD1 1 
ATOM   3786 N N   . ALA   B 1 97  ? -26.163 -34.423 -55.201 1.00 42.23 ? 97  ALA   B N   1 
ATOM   3787 C CA  . ALA   B 1 97  ? -27.131 -35.504 -55.064 1.00 41.72 ? 97  ALA   B CA  1 
ATOM   3788 C C   . ALA   B 1 97  ? -27.705 -35.887 -56.421 1.00 43.30 ? 97  ALA   B C   1 
ATOM   3789 O O   . ALA   B 1 97  ? -28.331 -35.064 -57.096 1.00 43.95 ? 97  ALA   B O   1 
ATOM   3790 C CB  . ALA   B 1 97  ? -28.251 -35.091 -54.111 1.00 42.84 ? 97  ALA   B CB  1 
ATOM   3791 N N   . GLY   B 1 98  ? -27.485 -37.140 -56.821 1.00 44.11 ? 98  GLY   B N   1 
ATOM   3792 C CA  . GLY   B 1 98  ? -28.010 -37.667 -58.062 1.00 45.79 ? 98  GLY   B CA  1 
ATOM   3793 C C   . GLY   B 1 98  ? -27.027 -37.701 -59.213 1.00 43.14 ? 98  GLY   B C   1 
ATOM   3794 O O   . GLY   B 1 98  ? -27.344 -38.285 -60.256 1.00 45.14 ? 98  GLY   B O   1 
ATOM   3795 N N   . LEU   B 1 99  ? -25.848 -37.096 -59.058 1.00 42.55 ? 99  LEU   B N   1 
ATOM   3796 C CA  . LEU   B 1 99  ? -24.855 -37.054 -60.117 1.00 45.10 ? 99  LEU   B CA  1 
ATOM   3797 C C   . LEU   B 1 99  ? -23.661 -37.944 -59.777 1.00 43.39 ? 99  LEU   B C   1 
ATOM   3798 O O   . LEU   B 1 99  ? -23.371 -38.183 -58.601 1.00 42.17 ? 99  LEU   B O   1 
ATOM   3799 C CB  . LEU   B 1 99  ? -24.369 -35.620 -60.363 1.00 42.66 ? 99  LEU   B CB  1 
ATOM   3800 C CG  . LEU   B 1 99  ? -25.405 -34.649 -60.938 1.00 43.75 ? 99  LEU   B CG  1 
ATOM   3801 C CD1 . LEU   B 1 99  ? -24.777 -33.293 -61.247 1.00 43.51 ? 99  LEU   B CD1 1 
ATOM   3802 C CD2 . LEU   B 1 99  ? -26.069 -35.228 -62.180 1.00 42.11 ? 99  LEU   B CD2 1 
ATOM   3803 N N   . PRO   B 1 100 ? -22.956 -38.455 -60.784 1.00 47.17 ? 100 PRO   B N   1 
ATOM   3804 C CA  . PRO   B 1 100 ? -21.805 -39.322 -60.509 1.00 45.81 ? 100 PRO   B CA  1 
ATOM   3805 C C   . PRO   B 1 100 ? -20.641 -38.546 -59.913 1.00 43.95 ? 100 PRO   B C   1 
ATOM   3806 O O   . PRO   B 1 100 ? -20.468 -37.350 -60.156 1.00 42.62 ? 100 PRO   B O   1 
ATOM   3807 C CB  . PRO   B 1 100 ? -21.442 -39.882 -61.892 1.00 39.77 ? 100 PRO   B CB  1 
ATOM   3808 C CG  . PRO   B 1 100 ? -22.651 -39.632 -62.749 1.00 40.11 ? 100 PRO   B CG  1 
ATOM   3809 C CD  . PRO   B 1 100 ? -23.253 -38.375 -62.223 1.00 44.98 ? 100 PRO   B CD  1 
ATOM   3810 N N   . THR   B 1 101 ? -19.840 -39.249 -59.115 1.00 42.52 ? 101 THR   B N   1 
ATOM   3811 C CA  . THR   B 1 101 ? -18.582 -38.731 -58.584 1.00 41.75 ? 101 THR   B CA  1 
ATOM   3812 C C   . THR   B 1 101 ? -17.536 -39.824 -58.754 1.00 41.28 ? 101 THR   B C   1 
ATOM   3813 O O   . THR   B 1 101 ? -17.540 -40.811 -58.010 1.00 43.18 ? 101 THR   B O   1 
ATOM   3814 C CB  . THR   B 1 101 ? -18.717 -38.320 -57.115 1.00 41.15 ? 101 THR   B CB  1 
ATOM   3815 O OG1 . THR   B 1 101 ? -19.755 -37.342 -56.985 1.00 42.95 ? 101 THR   B OG1 1 
ATOM   3816 C CG2 . THR   B 1 101 ? -17.409 -37.727 -56.601 1.00 39.05 ? 101 THR   B CG2 1 
ATOM   3817 N N   . SER   B 1 102 ? -16.644 -39.652 -59.733 1.00 39.28 ? 102 SER   B N   1 
ATOM   3818 C CA  . SER   B 1 102 ? -15.708 -40.697 -60.121 1.00 40.55 ? 102 SER   B CA  1 
ATOM   3819 C C   . SER   B 1 102 ? -14.244 -40.342 -59.920 1.00 42.23 ? 102 SER   B C   1 
ATOM   3820 O O   . SER   B 1 102 ? -13.423 -41.259 -59.818 1.00 40.51 ? 102 SER   B O   1 
ATOM   3821 C CB  . SER   B 1 102 ? -15.909 -41.078 -61.598 1.00 44.26 ? 102 SER   B CB  1 
ATOM   3822 O OG  . SER   B 1 102 ? -15.633 -39.981 -62.451 1.00 41.30 ? 102 SER   B OG  1 
ATOM   3823 N N   . TRP   B 1 103 ? -13.895 -39.056 -59.870 1.00 38.80 ? 103 TRP   B N   1 
ATOM   3824 C CA  . TRP   B 1 103 ? -12.502 -38.607 -59.828 1.00 41.69 ? 103 TRP   B CA  1 
ATOM   3825 C C   . TRP   B 1 103 ? -11.706 -39.125 -61.024 1.00 44.15 ? 103 TRP   B C   1 
ATOM   3826 O O   . TRP   B 1 103 ? -10.484 -39.282 -60.952 1.00 46.64 ? 103 TRP   B O   1 
ATOM   3827 C CB  . TRP   B 1 103 ? -11.814 -39.011 -58.522 1.00 41.57 ? 103 TRP   B CB  1 
ATOM   3828 C CG  . TRP   B 1 103 ? -12.352 -38.331 -57.301 1.00 39.84 ? 103 TRP   B CG  1 
ATOM   3829 C CD1 . TRP   B 1 103 ? -13.629 -37.901 -57.089 1.00 38.39 ? 103 TRP   B CD1 1 
ATOM   3830 C CD2 . TRP   B 1 103 ? -11.615 -37.995 -56.122 1.00 38.71 ? 103 TRP   B CD2 1 
ATOM   3831 N NE1 . TRP   B 1 103 ? -13.733 -37.327 -55.845 1.00 39.60 ? 103 TRP   B NE1 1 
ATOM   3832 C CE2 . TRP   B 1 103 ? -12.509 -37.369 -55.233 1.00 40.08 ? 103 TRP   B CE2 1 
ATOM   3833 C CE3 . TRP   B 1 103 ? -10.283 -38.164 -55.731 1.00 39.96 ? 103 TRP   B CE3 1 
ATOM   3834 C CZ2 . TRP   B 1 103 ? -12.114 -36.911 -53.976 1.00 41.73 ? 103 TRP   B CZ2 1 
ATOM   3835 C CZ3 . TRP   B 1 103 ? -9.893  -37.709 -54.483 1.00 37.49 ? 103 TRP   B CZ3 1 
ATOM   3836 C CH2 . TRP   B 1 103 ? -10.806 -37.091 -53.620 1.00 39.59 ? 103 TRP   B CH2 1 
ATOM   3837 N N   . GLY   B 1 104 ? -12.393 -39.400 -62.132 1.00 40.28 ? 104 GLY   B N   1 
ATOM   3838 C CA  . GLY   B 1 104 ? -11.746 -39.833 -63.350 1.00 42.16 ? 104 GLY   B CA  1 
ATOM   3839 C C   . GLY   B 1 104 ? -11.487 -41.317 -63.452 1.00 43.94 ? 104 GLY   B C   1 
ATOM   3840 O O   . GLY   B 1 104 ? -10.924 -41.760 -64.462 1.00 45.40 ? 104 GLY   B O   1 
ATOM   3841 N N   . PHE   B 1 105 ? -11.877 -42.099 -62.450 1.00 43.23 ? 105 PHE   B N   1 
ATOM   3842 C CA  . PHE   B 1 105 ? -11.677 -43.539 -62.489 1.00 43.47 ? 105 PHE   B CA  1 
ATOM   3843 C C   . PHE   B 1 105 ? -12.797 -44.211 -63.270 1.00 44.32 ? 105 PHE   B C   1 
ATOM   3844 O O   . PHE   B 1 105 ? -13.958 -43.799 -63.201 1.00 44.52 ? 105 PHE   B O   1 
ATOM   3845 C CB  . PHE   B 1 105 ? -11.615 -44.111 -61.071 1.00 43.83 ? 105 PHE   B CB  1 
ATOM   3846 C CG  . PHE   B 1 105 ? -10.445 -43.619 -60.268 1.00 43.30 ? 105 PHE   B CG  1 
ATOM   3847 C CD1 . PHE   B 1 105 ? -9.170  -44.099 -60.518 1.00 43.98 ? 105 PHE   B CD1 1 
ATOM   3848 C CD2 . PHE   B 1 105 ? -10.618 -42.684 -59.261 1.00 38.82 ? 105 PHE   B CD2 1 
ATOM   3849 C CE1 . PHE   B 1 105 ? -8.087  -43.652 -59.784 1.00 43.16 ? 105 PHE   B CE1 1 
ATOM   3850 C CE2 . PHE   B 1 105 ? -9.537  -42.237 -58.516 1.00 42.32 ? 105 PHE   B CE2 1 
ATOM   3851 C CZ  . PHE   B 1 105 ? -8.271  -42.721 -58.781 1.00 42.30 ? 105 PHE   B CZ  1 
ATOM   3852 N N   . ALA   B 1 106 ? -12.440 -45.253 -64.022 1.00 44.77 ? 106 ALA   B N   1 
ATOM   3853 C CA  . ALA   B 1 106 ? -13.452 -46.034 -64.724 1.00 45.43 ? 106 ALA   B CA  1 
ATOM   3854 C C   . ALA   B 1 106 ? -14.292 -46.844 -63.746 1.00 46.09 ? 106 ALA   B C   1 
ATOM   3855 O O   . ALA   B 1 106 ? -15.510 -46.968 -63.918 1.00 49.19 ? 106 ALA   B O   1 
ATOM   3856 C CB  . ALA   B 1 106 ? -12.789 -46.951 -65.751 1.00 43.34 ? 106 ALA   B CB  1 
ATOM   3857 N N   . GLU   B 1 107 ? -13.654 -47.396 -62.709 1.00 45.35 ? 107 GLU   B N   1 
ATOM   3858 C CA  . GLU   B 1 107 ? -14.368 -48.210 -61.729 1.00 47.05 ? 107 GLU   B CA  1 
ATOM   3859 C C   . GLU   B 1 107 ? -15.469 -47.424 -61.035 1.00 46.85 ? 107 GLU   B C   1 
ATOM   3860 O O   . GLU   B 1 107 ? -16.511 -47.990 -60.684 1.00 49.41 ? 107 GLU   B O   1 
ATOM   3861 C CB  . GLU   B 1 107 ? -13.390 -48.749 -60.685 1.00 47.58 ? 107 GLU   B CB  1 
ATOM   3862 C CG  . GLU   B 1 107 ? -12.010 -49.086 -61.220 1.00 55.21 ? 107 GLU   B CG  1 
ATOM   3863 C CD  . GLU   B 1 107 ? -10.957 -49.042 -60.134 1.00 60.53 ? 107 GLU   B CD  1 
ATOM   3864 O OE1 . GLU   B 1 107 ? -11.332 -49.061 -58.945 1.00 57.44 ? 107 GLU   B OE1 1 
ATOM   3865 O OE2 . GLU   B 1 107 ? -9.756  -48.983 -60.465 1.00 67.09 ? 107 GLU   B OE2 1 
ATOM   3866 N N   . HIS   B 1 108 ? -15.255 -46.126 -60.822 1.00 47.47 ? 108 HIS   B N   1 
ATOM   3867 C CA  . HIS   B 1 108 ? -16.169 -45.281 -60.070 1.00 45.07 ? 108 HIS   B CA  1 
ATOM   3868 C C   . HIS   B 1 108 ? -17.037 -44.411 -60.970 1.00 46.49 ? 108 HIS   B C   1 
ATOM   3869 O O   . HIS   B 1 108 ? -17.637 -43.443 -60.490 1.00 45.64 ? 108 HIS   B O   1 
ATOM   3870 C CB  . HIS   B 1 108 ? -15.382 -44.407 -59.092 1.00 44.64 ? 108 HIS   B CB  1 
ATOM   3871 C CG  . HIS   B 1 108 ? -14.443 -45.177 -58.216 1.00 42.92 ? 108 HIS   B CG  1 
ATOM   3872 N ND1 . HIS   B 1 108 ? -14.835 -46.295 -57.511 1.00 39.58 ? 108 HIS   B ND1 1 
ATOM   3873 C CD2 . HIS   B 1 108 ? -13.133 -44.991 -57.929 1.00 42.75 ? 108 HIS   B CD2 1 
ATOM   3874 C CE1 . HIS   B 1 108 ? -13.806 -46.765 -56.829 1.00 41.88 ? 108 HIS   B CE1 1 
ATOM   3875 N NE2 . HIS   B 1 108 ? -12.761 -45.991 -57.064 1.00 41.01 ? 108 HIS   B NE2 1 
ATOM   3876 N N   . ALA   B 1 109 ? -17.123 -44.741 -62.262 1.00 47.37 ? 109 ALA   B N   1 
ATOM   3877 C CA  . ALA   B 1 109 ? -17.885 -43.918 -63.196 1.00 45.87 ? 109 ALA   B CA  1 
ATOM   3878 C C   . ALA   B 1 109 ? -19.366 -43.884 -62.840 1.00 46.94 ? 109 ALA   B C   1 
ATOM   3879 O O   . ALA   B 1 109 ? -20.034 -42.866 -63.061 1.00 49.25 ? 109 ALA   B O   1 
ATOM   3880 C CB  . ALA   B 1 109 ? -17.695 -44.430 -64.625 1.00 47.60 ? 109 ALA   B CB  1 
ATOM   3881 N N   . ASP   B 1 110 ? -19.896 -44.974 -62.279 1.00 48.93 ? 110 ASP   B N   1 
ATOM   3882 C CA  . ASP   B 1 110 ? -21.310 -45.067 -61.936 1.00 48.63 ? 110 ASP   B CA  1 
ATOM   3883 C C   . ASP   B 1 110 ? -21.546 -44.992 -60.429 1.00 48.75 ? 110 ASP   B C   1 
ATOM   3884 O O   . ASP   B 1 110 ? -22.499 -45.582 -59.917 1.00 48.88 ? 110 ASP   B O   1 
ATOM   3885 C CB  . ASP   B 1 110 ? -21.915 -46.348 -62.510 1.00 48.66 ? 110 ASP   B CB  1 
ATOM   3886 C CG  . ASP   B 1 110 ? -21.299 -47.602 -61.921 1.00 53.52 ? 110 ASP   B CG  1 
ATOM   3887 O OD1 . ASP   B 1 110 ? -20.147 -47.535 -61.450 1.00 52.62 ? 110 ASP   B OD1 1 
ATOM   3888 O OD2 . ASP   B 1 110 ? -21.965 -48.656 -61.935 1.00 52.77 ? 110 ASP   B OD2 1 
ATOM   3889 N N   . HIS   B 1 111 ? -20.691 -44.272 -59.705 1.00 51.00 ? 111 HIS   B N   1 
ATOM   3890 C CA  . HIS   B 1 111 ? -20.910 -44.006 -58.286 1.00 45.89 ? 111 HIS   B CA  1 
ATOM   3891 C C   . HIS   B 1 111 ? -21.766 -42.753 -58.157 1.00 43.69 ? 111 HIS   B C   1 
ATOM   3892 O O   . HIS   B 1 111 ? -21.291 -41.640 -58.404 1.00 44.03 ? 111 HIS   B O   1 
ATOM   3893 C CB  . HIS   B 1 111 ? -19.588 -43.837 -57.543 1.00 43.98 ? 111 HIS   B CB  1 
ATOM   3894 C CG  . HIS   B 1 111 ? -19.733 -43.199 -56.196 1.00 47.17 ? 111 HIS   B CG  1 
ATOM   3895 N ND1 . HIS   B 1 111 ? -20.452 -43.778 -55.172 1.00 45.47 ? 111 HIS   B ND1 1 
ATOM   3896 C CD2 . HIS   B 1 111 ? -19.261 -42.027 -55.708 1.00 44.58 ? 111 HIS   B CD2 1 
ATOM   3897 C CE1 . HIS   B 1 111 ? -20.413 -42.993 -54.111 1.00 45.82 ? 111 HIS   B CE1 1 
ATOM   3898 N NE2 . HIS   B 1 111 ? -19.697 -41.924 -54.410 1.00 45.22 ? 111 HIS   B NE2 1 
ATOM   3899 N N   . ILE   B 1 112 ? -23.024 -42.931 -57.764 1.00 43.23 ? 112 ILE   B N   1 
ATOM   3900 C CA  . ILE   B 1 112 ? -23.979 -41.836 -57.655 1.00 43.20 ? 112 ILE   B CA  1 
ATOM   3901 C C   . ILE   B 1 112 ? -24.015 -41.359 -56.211 1.00 45.11 ? 112 ILE   B C   1 
ATOM   3902 O O   . ILE   B 1 112 ? -24.166 -42.167 -55.285 1.00 42.84 ? 112 ILE   B O   1 
ATOM   3903 C CB  . ILE   B 1 112 ? -25.378 -42.267 -58.125 1.00 42.23 ? 112 ILE   B CB  1 
ATOM   3904 C CG1 . ILE   B 1 112 ? -25.301 -42.909 -59.511 1.00 43.52 ? 112 ILE   B CG1 1 
ATOM   3905 C CG2 . ILE   B 1 112 ? -26.323 -41.076 -58.139 1.00 40.16 ? 112 ILE   B CG2 1 
ATOM   3906 C CD1 . ILE   B 1 112 ? -24.677 -42.024 -60.566 1.00 43.99 ? 112 ILE   B CD1 1 
ATOM   3907 N N   . ALA   B 1 113 ? -23.875 -40.051 -56.019 1.00 44.93 ? 113 ALA   B N   1 
ATOM   3908 C CA  . ALA   B 1 113 ? -23.954 -39.472 -54.687 1.00 42.27 ? 113 ALA   B CA  1 
ATOM   3909 C C   . ALA   B 1 113 ? -25.409 -39.340 -54.259 1.00 44.98 ? 113 ALA   B C   1 
ATOM   3910 O O   . ALA   B 1 113 ? -26.286 -39.033 -55.072 1.00 42.16 ? 113 ALA   B O   1 
ATOM   3911 C CB  . ALA   B 1 113 ? -23.264 -38.108 -54.652 1.00 41.98 ? 113 ALA   B CB  1 
ATOM   3912 N N   . THR   B 1 114 ? -25.665 -39.577 -52.972 1.00 43.00 ? 114 THR   B N   1 
ATOM   3913 C CA  . THR   B 1 114 ? -27.017 -39.485 -52.437 1.00 40.75 ? 114 THR   B CA  1 
ATOM   3914 C C   . THR   B 1 114 ? -27.316 -38.143 -51.786 1.00 44.24 ? 114 THR   B C   1 
ATOM   3915 O O   . THR   B 1 114 ? -28.490 -37.825 -51.566 1.00 45.62 ? 114 THR   B O   1 
ATOM   3916 C CB  . THR   B 1 114 ? -27.266 -40.598 -51.410 1.00 41.83 ? 114 THR   B CB  1 
ATOM   3917 O OG1 . THR   B 1 114 ? -26.386 -40.428 -50.293 1.00 49.15 ? 114 THR   B OG1 1 
ATOM   3918 C CG2 . THR   B 1 114 ? -27.011 -41.955 -52.030 1.00 43.35 ? 114 THR   B CG2 1 
ATOM   3919 N N   . ALA   B 1 115 ? -26.292 -37.355 -51.474 1.00 45.40 ? 115 ALA   B N   1 
ATOM   3920 C CA  . ALA   B 1 115 ? -26.484 -36.079 -50.806 1.00 44.78 ? 115 ALA   B CA  1 
ATOM   3921 C C   . ALA   B 1 115 ? -25.454 -35.086 -51.317 1.00 41.97 ? 115 ALA   B C   1 
ATOM   3922 O O   . ALA   B 1 115 ? -24.333 -35.459 -51.675 1.00 42.14 ? 115 ALA   B O   1 
ATOM   3923 C CB  . ALA   B 1 115 ? -26.375 -36.220 -49.283 1.00 44.32 ? 115 ALA   B CB  1 
ATOM   3924 N N   . ASP   B 1 116 ? -25.849 -33.818 -51.340 1.00 40.70 ? 116 ASP   B N   1 
ATOM   3925 C CA  . ASP   B 1 116 ? -24.946 -32.758 -51.760 1.00 41.39 ? 116 ASP   B CA  1 
ATOM   3926 C C   . ASP   B 1 116 ? -23.752 -32.652 -50.818 1.00 43.06 ? 116 ASP   B C   1 
ATOM   3927 O O   . ASP   B 1 116 ? -23.841 -32.946 -49.622 1.00 44.44 ? 116 ASP   B O   1 
ATOM   3928 C CB  . ASP   B 1 116 ? -25.684 -31.420 -51.806 1.00 41.86 ? 116 ASP   B CB  1 
ATOM   3929 C CG  . ASP   B 1 116 ? -26.776 -31.398 -52.846 1.00 47.13 ? 116 ASP   B CG  1 
ATOM   3930 O OD1 . ASP   B 1 116 ? -26.555 -31.935 -53.948 1.00 43.07 ? 116 ASP   B OD1 1 
ATOM   3931 O OD2 . ASP   B 1 116 ? -27.852 -30.837 -52.564 1.00 47.50 ? 116 ASP   B OD2 1 
ATOM   3932 N N   . SER   B 1 117 ? -22.618 -32.243 -51.379 1.00 42.14 ? 117 SER   B N   1 
ATOM   3933 C CA  . SER   B 1 117 ? -21.496 -31.838 -50.551 1.00 42.91 ? 117 SER   B CA  1 
ATOM   3934 C C   . SER   B 1 117 ? -21.858 -30.563 -49.790 1.00 42.08 ? 117 SER   B C   1 
ATOM   3935 O O   . SER   B 1 117 ? -22.847 -29.886 -50.092 1.00 40.38 ? 117 SER   B O   1 
ATOM   3936 C CB  . SER   B 1 117 ? -20.245 -31.627 -51.404 1.00 42.41 ? 117 SER   B CB  1 
ATOM   3937 O OG  . SER   B 1 117 ? -20.455 -30.629 -52.383 1.00 44.79 ? 117 SER   B OG  1 
ATOM   3938 N N   . LEU   B 1 118 ? -21.052 -30.242 -48.774 1.00 42.56 ? 118 LEU   B N   1 
ATOM   3939 C CA  . LEU   B 1 118 ? -21.340 -29.062 -47.965 1.00 43.25 ? 118 LEU   B CA  1 
ATOM   3940 C C   . LEU   B 1 118 ? -21.240 -27.788 -48.794 1.00 41.27 ? 118 LEU   B C   1 
ATOM   3941 O O   . LEU   B 1 118 ? -22.081 -26.890 -48.670 1.00 42.81 ? 118 LEU   B O   1 
ATOM   3942 C CB  . LEU   B 1 118 ? -20.398 -29.001 -46.763 1.00 40.08 ? 118 LEU   B CB  1 
ATOM   3943 C CG  . LEU   B 1 118 ? -20.677 -27.885 -45.750 1.00 44.94 ? 118 LEU   B CG  1 
ATOM   3944 C CD1 . LEU   B 1 118 ? -20.548 -28.410 -44.331 1.00 47.86 ? 118 LEU   B CD1 1 
ATOM   3945 C CD2 . LEU   B 1 118 ? -19.761 -26.683 -45.962 1.00 43.48 ? 118 LEU   B CD2 1 
ATOM   3946 N N   . VAL   B 1 119 ? -20.216 -27.692 -49.645 1.00 38.27 ? 119 VAL   B N   1 
ATOM   3947 C CA  . VAL   B 1 119 ? -20.052 -26.507 -50.481 1.00 40.95 ? 119 VAL   B CA  1 
ATOM   3948 C C   . VAL   B 1 119 ? -21.230 -26.362 -51.435 1.00 40.99 ? 119 VAL   B C   1 
ATOM   3949 O O   . VAL   B 1 119 ? -21.764 -25.261 -51.625 1.00 40.41 ? 119 VAL   B O   1 
ATOM   3950 C CB  . VAL   B 1 119 ? -18.708 -26.569 -51.232 1.00 40.34 ? 119 VAL   B CB  1 
ATOM   3951 C CG1 . VAL   B 1 119 ? -18.734 -25.666 -52.457 1.00 42.80 ? 119 VAL   B CG1 1 
ATOM   3952 C CG2 . VAL   B 1 119 ? -17.569 -26.172 -50.302 1.00 36.59 ? 119 VAL   B CG2 1 
ATOM   3953 N N   . VAL   B 1 120 ? -21.661 -27.469 -52.043 1.00 40.77 ? 120 VAL   B N   1 
ATOM   3954 C CA  . VAL   B 1 120 ? -22.831 -27.428 -52.915 1.00 41.48 ? 120 VAL   B CA  1 
ATOM   3955 C C   . VAL   B 1 120 ? -24.072 -27.039 -52.120 1.00 40.85 ? 120 VAL   B C   1 
ATOM   3956 O O   . VAL   B 1 120 ? -24.886 -26.226 -52.572 1.00 43.08 ? 120 VAL   B O   1 
ATOM   3957 C CB  . VAL   B 1 120 ? -23.011 -28.779 -53.632 1.00 40.96 ? 120 VAL   B CB  1 
ATOM   3958 C CG1 . VAL   B 1 120 ? -24.371 -28.852 -54.307 1.00 40.88 ? 120 VAL   B CG1 1 
ATOM   3959 C CG2 . VAL   B 1 120 ? -21.910 -28.975 -54.661 1.00 39.85 ? 120 VAL   B CG2 1 
ATOM   3960 N N   . SER   B 1 121 ? -24.227 -27.599 -50.917 1.00 40.76 ? 121 SER   B N   1 
ATOM   3961 C CA  . SER   B 1 121 ? -25.400 -27.293 -50.103 1.00 41.95 ? 121 SER   B CA  1 
ATOM   3962 C C   . SER   B 1 121 ? -25.445 -25.818 -49.720 1.00 42.09 ? 121 SER   B C   1 
ATOM   3963 O O   . SER   B 1 121 ? -26.517 -25.202 -49.729 1.00 41.12 ? 121 SER   B O   1 
ATOM   3964 C CB  . SER   B 1 121 ? -25.415 -28.171 -48.853 1.00 42.06 ? 121 SER   B CB  1 
ATOM   3965 O OG  . SER   B 1 121 ? -26.530 -27.859 -48.032 1.00 52.05 ? 121 SER   B OG  1 
ATOM   3966 N N   . ARG   B 1 122 ? -24.295 -25.235 -49.376 1.00 40.42 ? 122 ARG   B N   1 
ATOM   3967 C CA  . ARG   B 1 122 ? -24.252 -23.812 -49.049 1.00 40.51 ? 122 ARG   B CA  1 
ATOM   3968 C C   . ARG   B 1 122 ? -24.571 -22.960 -50.271 1.00 41.15 ? 122 ARG   B C   1 
ATOM   3969 O O   . ARG   B 1 122 ? -25.374 -22.023 -50.196 1.00 41.47 ? 122 ARG   B O   1 
ATOM   3970 C CB  . ARG   B 1 122 ? -22.877 -23.444 -48.491 1.00 41.54 ? 122 ARG   B CB  1 
ATOM   3971 C CG  . ARG   B 1 122 ? -22.545 -24.081 -47.155 1.00 40.70 ? 122 ARG   B CG  1 
ATOM   3972 C CD  . ARG   B 1 122 ? -23.100 -23.266 -46.004 1.00 41.64 ? 122 ARG   B CD  1 
ATOM   3973 N NE  . ARG   B 1 122 ? -22.354 -23.494 -44.773 1.00 43.82 ? 122 ARG   B NE  1 
ATOM   3974 C CZ  . ARG   B 1 122 ? -21.348 -22.739 -44.356 1.00 43.44 ? 122 ARG   B CZ  1 
ATOM   3975 N NH1 . ARG   B 1 122 ? -20.944 -21.686 -45.045 1.00 45.76 ? 122 ARG   B NH1 1 
ATOM   3976 N NH2 . ARG   B 1 122 ? -20.732 -23.050 -43.219 1.00 42.70 ? 122 ARG   B NH2 1 
ATOM   3977 N N   . LEU   B 1 123 ? -23.939 -23.267 -51.406 1.00 39.29 ? 123 LEU   B N   1 
ATOM   3978 C CA  . LEU   B 1 123 ? -24.161 -22.485 -52.618 1.00 42.76 ? 123 LEU   B CA  1 
ATOM   3979 C C   . LEU   B 1 123 ? -25.604 -22.598 -53.091 1.00 41.36 ? 123 LEU   B C   1 
ATOM   3980 O O   . LEU   B 1 123 ? -26.187 -21.616 -53.563 1.00 40.65 ? 123 LEU   B O   1 
ATOM   3981 C CB  . LEU   B 1 123 ? -23.192 -22.934 -53.711 1.00 39.64 ? 123 LEU   B CB  1 
ATOM   3982 C CG  . LEU   B 1 123 ? -21.727 -22.555 -53.489 1.00 41.42 ? 123 LEU   B CG  1 
ATOM   3983 C CD1 . LEU   B 1 123 ? -20.825 -23.311 -54.451 1.00 36.85 ? 123 LEU   B CD1 1 
ATOM   3984 C CD2 . LEU   B 1 123 ? -21.533 -21.052 -53.640 1.00 39.80 ? 123 LEU   B CD2 1 
ATOM   3985 N N   . LYS   B 1 124 ? -26.199 -23.788 -52.968 1.00 40.35 ? 124 LYS   B N   1 
ATOM   3986 C CA  . LYS   B 1 124 ? -27.608 -23.947 -53.316 1.00 41.05 ? 124 LYS   B CA  1 
ATOM   3987 C C   . LYS   B 1 124 ? -28.497 -23.124 -52.393 1.00 44.05 ? 124 LYS   B C   1 
ATOM   3988 O O   . LYS   B 1 124 ? -29.468 -22.506 -52.841 1.00 44.50 ? 124 LYS   B O   1 
ATOM   3989 C CB  . LYS   B 1 124 ? -28.005 -25.422 -53.254 1.00 38.80 ? 124 LYS   B CB  1 
ATOM   3990 C CG  . LYS   B 1 124 ? -27.604 -26.244 -54.464 1.00 42.57 ? 124 LYS   B CG  1 
ATOM   3991 C CD  . LYS   B 1 124 ? -28.002 -27.699 -54.285 1.00 43.79 ? 124 LYS   B CD  1 
ATOM   3992 C CE  . LYS   B 1 124 ? -27.791 -28.487 -55.568 1.00 44.20 ? 124 LYS   B CE  1 
ATOM   3993 N NZ  . LYS   B 1 124 ? -28.088 -29.938 -55.394 1.00 44.67 ? 124 LYS   B NZ  1 
ATOM   3994 N N   . ALA   B 1 125 ? -28.183 -23.112 -51.094 1.00 41.66 ? 125 ALA   B N   1 
ATOM   3995 C CA  . ALA   B 1 125 ? -28.969 -22.336 -50.139 1.00 39.53 ? 125 ALA   B CA  1 
ATOM   3996 C C   . ALA   B 1 125 ? -28.909 -20.847 -50.443 1.00 41.84 ? 125 ALA   B C   1 
ATOM   3997 O O   . ALA   B 1 125 ? -29.854 -20.113 -50.135 1.00 41.48 ? 125 ALA   B O   1 
ATOM   3998 C CB  . ALA   B 1 125 ? -28.483 -22.611 -48.715 1.00 43.72 ? 125 ALA   B CB  1 
ATOM   3999 N N   . ALA   B 1 126 ? -27.814 -20.383 -51.042 1.00 42.10 ? 126 ALA   B N   1 
ATOM   4000 C CA  . ALA   B 1 126 ? -27.722 -19.003 -51.499 1.00 41.14 ? 126 ALA   B CA  1 
ATOM   4001 C C   . ALA   B 1 126 ? -28.456 -18.767 -52.812 1.00 45.19 ? 126 ALA   B C   1 
ATOM   4002 O O   . ALA   B 1 126 ? -28.427 -17.643 -53.323 1.00 45.54 ? 126 ALA   B O   1 
ATOM   4003 C CB  . ALA   B 1 126 ? -26.255 -18.591 -51.643 1.00 40.63 ? 126 ALA   B CB  1 
ATOM   4004 N N   . GLY   B 1 127 ? -29.097 -19.790 -53.368 1.00 46.37 ? 127 GLY   B N   1 
ATOM   4005 C CA  . GLY   B 1 127 ? -29.879 -19.650 -54.576 1.00 45.11 ? 127 GLY   B CA  1 
ATOM   4006 C C   . GLY   B 1 127 ? -29.206 -20.086 -55.858 1.00 45.31 ? 127 GLY   B C   1 
ATOM   4007 O O   . GLY   B 1 127 ? -29.789 -19.897 -56.932 1.00 47.88 ? 127 GLY   B O   1 
ATOM   4008 N N   . ALA   B 1 128 ? -28.010 -20.664 -55.788 1.00 41.99 ? 128 ALA   B N   1 
ATOM   4009 C CA  . ALA   B 1 128 ? -27.299 -21.043 -57.000 1.00 43.06 ? 128 ALA   B CA  1 
ATOM   4010 C C   . ALA   B 1 128 ? -27.958 -22.247 -57.661 1.00 43.88 ? 128 ALA   B C   1 
ATOM   4011 O O   . ALA   B 1 128 ? -28.467 -23.152 -56.994 1.00 44.87 ? 128 ALA   B O   1 
ATOM   4012 C CB  . ALA   B 1 128 ? -25.835 -21.356 -56.694 1.00 43.24 ? 128 ALA   B CB  1 
ATOM   4013 N N   . VAL   B 1 129 ? -27.945 -22.249 -58.991 1.00 43.10 ? 129 VAL   B N   1 
ATOM   4014 C CA  . VAL   B 1 129 ? -28.476 -23.346 -59.793 1.00 43.11 ? 129 VAL   B CA  1 
ATOM   4015 C C   . VAL   B 1 129 ? -27.297 -24.065 -60.434 1.00 43.26 ? 129 VAL   B C   1 
ATOM   4016 O O   . VAL   B 1 129 ? -26.463 -23.437 -61.098 1.00 44.51 ? 129 VAL   B O   1 
ATOM   4017 C CB  . VAL   B 1 129 ? -29.471 -22.848 -60.853 1.00 42.44 ? 129 VAL   B CB  1 
ATOM   4018 C CG1 . VAL   B 1 129 ? -29.818 -23.964 -61.831 1.00 45.72 ? 129 VAL   B CG1 1 
ATOM   4019 C CG2 . VAL   B 1 129 ? -30.731 -22.315 -60.186 1.00 43.68 ? 129 VAL   B CG2 1 
ATOM   4020 N N   . PHE   B 1 130 ? -27.225 -25.378 -60.239 1.00 40.96 ? 130 PHE   B N   1 
ATOM   4021 C CA  . PHE   B 1 130 ? -26.094 -26.172 -60.703 1.00 43.85 ? 130 PHE   B CA  1 
ATOM   4022 C C   . PHE   B 1 130 ? -26.450 -26.886 -62.003 1.00 44.99 ? 130 PHE   B C   1 
ATOM   4023 O O   . PHE   B 1 130 ? -27.329 -27.756 -62.025 1.00 47.38 ? 130 PHE   B O   1 
ATOM   4024 C CB  . PHE   B 1 130 ? -25.655 -27.168 -59.630 1.00 39.23 ? 130 PHE   B CB  1 
ATOM   4025 C CG  . PHE   B 1 130 ? -24.791 -26.559 -58.559 1.00 43.08 ? 130 PHE   B CG  1 
ATOM   4026 C CD1 . PHE   B 1 130 ? -25.360 -25.912 -57.474 1.00 40.72 ? 130 PHE   B CD1 1 
ATOM   4027 C CD2 . PHE   B 1 130 ? -23.410 -26.628 -58.642 1.00 42.03 ? 130 PHE   B CD2 1 
ATOM   4028 C CE1 . PHE   B 1 130 ? -24.568 -25.351 -56.490 1.00 39.66 ? 130 PHE   B CE1 1 
ATOM   4029 C CE2 . PHE   B 1 130 ? -22.612 -26.066 -57.661 1.00 40.42 ? 130 PHE   B CE2 1 
ATOM   4030 C CZ  . PHE   B 1 130 ? -23.191 -25.430 -56.585 1.00 41.32 ? 130 PHE   B CZ  1 
ATOM   4031 N N   . LEU   B 1 131 ? -25.753 -26.519 -63.081 1.00 43.44 ? 131 LEU   B N   1 
ATOM   4032 C CA  . LEU   B 1 131 ? -25.975 -27.110 -64.395 1.00 46.80 ? 131 LEU   B CA  1 
ATOM   4033 C C   . LEU   B 1 131 ? -25.266 -28.443 -64.575 1.00 46.72 ? 131 LEU   B C   1 
ATOM   4034 O O   . LEU   B 1 131 ? -25.705 -29.258 -65.394 1.00 48.42 ? 131 LEU   B O   1 
ATOM   4035 C CB  . LEU   B 1 131 ? -25.509 -26.149 -65.490 1.00 42.57 ? 131 LEU   B CB  1 
ATOM   4036 C CG  . LEU   B 1 131 ? -26.105 -24.744 -65.503 1.00 47.92 ? 131 LEU   B CG  1 
ATOM   4037 C CD1 . LEU   B 1 131 ? -25.428 -23.905 -66.567 1.00 44.52 ? 131 LEU   B CD1 1 
ATOM   4038 C CD2 . LEU   B 1 131 ? -27.601 -24.805 -65.736 1.00 46.59 ? 131 LEU   B CD2 1 
ATOM   4039 N N   . GLY   B 1 132 ? -24.180 -28.673 -63.849 1.00 46.54 ? 132 GLY   B N   1 
ATOM   4040 C CA  . GLY   B 1 132 ? -23.427 -29.902 -63.998 1.00 43.25 ? 132 GLY   B CA  1 
ATOM   4041 C C   . GLY   B 1 132 ? -22.063 -29.769 -63.343 1.00 43.73 ? 132 GLY   B C   1 
ATOM   4042 O O   . GLY   B 1 132 ? -21.858 -28.925 -62.472 1.00 41.98 ? 132 GLY   B O   1 
ATOM   4043 N N   . LYS   B 1 133 ? -21.142 -30.622 -63.785 1.00 43.37 ? 133 LYS   B N   1 
ATOM   4044 C CA  . LYS   B 1 133 ? -19.819 -30.697 -63.189 1.00 40.66 ? 133 LYS   B CA  1 
ATOM   4045 C C   . LYS   B 1 133 ? -18.749 -30.686 -64.274 1.00 41.41 ? 133 LYS   B C   1 
ATOM   4046 O O   . LYS   B 1 133 ? -19.004 -31.017 -65.436 1.00 43.73 ? 133 LYS   B O   1 
ATOM   4047 C CB  . LYS   B 1 133 ? -19.688 -31.939 -62.293 1.00 41.80 ? 133 LYS   B CB  1 
ATOM   4048 C CG  . LYS   B 1 133 ? -20.747 -31.990 -61.196 1.00 40.44 ? 133 LYS   B CG  1 
ATOM   4049 C CD  . LYS   B 1 133 ? -20.285 -32.745 -59.966 1.00 45.38 ? 133 LYS   B CD  1 
ATOM   4050 C CE  . LYS   B 1 133 ? -20.294 -34.242 -60.188 1.00 46.22 ? 133 LYS   B CE  1 
ATOM   4051 N NZ  . LYS   B 1 133 ? -19.885 -34.981 -58.957 1.00 41.07 ? 133 LYS   B NZ  1 
ATOM   4052 N N   . SER   B 1 134 ? -17.543 -30.288 -63.876 1.00 40.92 ? 134 SER   B N   1 
ATOM   4053 C CA  . SER   B 1 134 ? -16.450 -30.023 -64.799 1.00 41.95 ? 134 SER   B CA  1 
ATOM   4054 C C   . SER   B 1 134 ? -15.372 -31.095 -64.699 1.00 40.53 ? 134 SER   B C   1 
ATOM   4055 O O   . SER   B 1 134 ? -15.251 -31.801 -63.694 1.00 42.74 ? 134 SER   B O   1 
ATOM   4056 C CB  . SER   B 1 134 ? -15.837 -28.643 -64.539 1.00 42.51 ? 134 SER   B CB  1 
ATOM   4057 O OG  . SER   B 1 134 ? -15.503 -28.478 -63.173 1.00 42.47 ? 134 SER   B OG  1 
ATOM   4058 N N   . ASN   B 1 135 ? -14.564 -31.176 -65.755 1.00 39.58 ? 135 ASN   B N   1 
ATOM   4059 C CA  . ASN   B 1 135 ? -13.651 -32.292 -65.961 1.00 41.19 ? 135 ASN   B CA  1 
ATOM   4060 C C   . ASN   B 1 135 ? -12.452 -32.227 -65.016 1.00 42.85 ? 135 ASN   B C   1 
ATOM   4061 O O   . ASN   B 1 135 ? -12.089 -31.172 -64.485 1.00 43.51 ? 135 ASN   B O   1 
ATOM   4062 C CB  . ASN   B 1 135 ? -13.170 -32.321 -67.410 1.00 39.60 ? 135 ASN   B CB  1 
ATOM   4063 C CG  . ASN   B 1 135 ? -12.584 -33.661 -67.805 1.00 39.42 ? 135 ASN   B CG  1 
ATOM   4064 O OD1 . ASN   B 1 135 ? -12.871 -34.682 -67.182 1.00 37.11 ? 135 ASN   B OD1 1 
ATOM   4065 N ND2 . ASN   B 1 135 ? -11.760 -33.664 -68.846 1.00 38.06 ? 135 ASN   B ND2 1 
ATOM   4066 N N   . ILE   B 1 136 ? -11.825 -33.386 -64.832 1.00 42.39 ? 136 ILE   B N   1 
ATOM   4067 C CA  . ILE   B 1 136 ? -10.753 -33.585 -63.861 1.00 44.71 ? 136 ILE   B CA  1 
ATOM   4068 C C   . ILE   B 1 136 ? -9.800  -34.654 -64.388 1.00 45.30 ? 136 ILE   B C   1 
ATOM   4069 O O   . ILE   B 1 136 ? -10.175 -35.427 -65.281 1.00 46.08 ? 136 ILE   B O   1 
ATOM   4070 C CB  . ILE   B 1 136 ? -11.328 -33.976 -62.488 1.00 45.12 ? 136 ILE   B CB  1 
ATOM   4071 C CG1 . ILE   B 1 136 ? -12.512 -34.926 -62.652 1.00 43.92 ? 136 ILE   B CG1 1 
ATOM   4072 C CG2 . ILE   B 1 136 ? -11.828 -32.770 -61.738 1.00 42.56 ? 136 ILE   B CG2 1 
ATOM   4073 C CD1 . ILE   B 1 136 ? -12.135 -36.343 -62.900 1.00 47.34 ? 136 ILE   B CD1 1 
ATOM   4074 N N   . PRO   B 1 137 ? -8.572  -34.732 -63.886 1.00 45.74 ? 137 PRO   B N   1 
ATOM   4075 C CA  . PRO   B 1 137 ? -7.709  -35.874 -64.192 1.00 46.57 ? 137 PRO   B CA  1 
ATOM   4076 C C   . PRO   B 1 137 ? -8.044  -37.066 -63.306 1.00 45.50 ? 137 PRO   B C   1 
ATOM   4077 O O   . PRO   B 1 137 ? -8.818  -36.977 -62.352 1.00 43.92 ? 137 PRO   B O   1 
ATOM   4078 C CB  . PRO   B 1 137 ? -6.305  -35.342 -63.889 1.00 44.80 ? 137 PRO   B CB  1 
ATOM   4079 C CG  . PRO   B 1 137 ? -6.535  -34.327 -62.828 1.00 43.92 ? 137 PRO   B CG  1 
ATOM   4080 C CD  . PRO   B 1 137 ? -7.831  -33.664 -63.204 1.00 46.13 ? 137 PRO   B CD  1 
ATOM   4081 N N   . VAL   B 1 138 ? -7.429  -38.198 -63.642 1.00 44.48 ? 138 VAL   B N   1 
ATOM   4082 C CA  . VAL   B 1 138 ? -7.655  -39.430 -62.895 1.00 44.98 ? 138 VAL   B CA  1 
ATOM   4083 C C   . VAL   B 1 138 ? -7.064  -39.279 -61.500 1.00 42.11 ? 138 VAL   B C   1 
ATOM   4084 O O   . VAL   B 1 138 ? -5.864  -39.023 -61.344 1.00 42.30 ? 138 VAL   B O   1 
ATOM   4085 C CB  . VAL   B 1 138 ? -7.051  -40.633 -63.629 1.00 41.73 ? 138 VAL   B CB  1 
ATOM   4086 C CG1 . VAL   B 1 138 ? -7.344  -41.918 -62.872 1.00 43.10 ? 138 VAL   B CG1 1 
ATOM   4087 C CG2 . VAL   B 1 138 ? -7.590  -40.710 -65.046 1.00 42.49 ? 138 VAL   B CG2 1 
ATOM   4088 N N   . GLY   B 1 139 ? -7.908  -39.434 -60.481 1.00 42.92 ? 139 GLY   B N   1 
ATOM   4089 C CA  . GLY   B 1 139 ? -7.448  -39.299 -59.114 1.00 41.65 ? 139 GLY   B CA  1 
ATOM   4090 C C   . GLY   B 1 139 ? -7.030  -37.905 -58.717 1.00 43.78 ? 139 GLY   B C   1 
ATOM   4091 O O   . GLY   B 1 139 ? -6.396  -37.736 -57.673 1.00 42.18 ? 139 GLY   B O   1 
ATOM   4092 N N   . LEU   B 1 140 ? -7.358  -36.897 -59.528 1.00 42.93 ? 140 LEU   B N   1 
ATOM   4093 C CA  . LEU   B 1 140 ? -6.986  -35.509 -59.247 1.00 43.35 ? 140 LEU   B CA  1 
ATOM   4094 C C   . LEU   B 1 140 ? -5.475  -35.366 -59.068 1.00 46.28 ? 140 LEU   B C   1 
ATOM   4095 O O   . LEU   B 1 140 ? -5.007  -34.607 -58.220 1.00 49.68 ? 140 LEU   B O   1 
ATOM   4096 C CB  . LEU   B 1 140 ? -7.719  -34.975 -58.011 1.00 43.94 ? 140 LEU   B CB  1 
ATOM   4097 C CG  . LEU   B 1 140 ? -9.227  -35.215 -57.869 1.00 42.35 ? 140 LEU   B CG  1 
ATOM   4098 C CD1 . LEU   B 1 140 ? -9.744  -34.581 -56.582 1.00 40.55 ? 140 LEU   B CD1 1 
ATOM   4099 C CD2 . LEU   B 1 140 ? -10.005 -34.701 -59.066 1.00 38.03 ? 140 LEU   B CD2 1 
ATOM   4100 N N   . ALA   B 1 141 ? -4.703  -36.103 -59.865 1.00 42.70 ? 141 ALA   B N   1 
ATOM   4101 C CA  . ALA   B 1 141 ? -3.270  -36.265 -59.649 1.00 45.76 ? 141 ALA   B CA  1 
ATOM   4102 C C   . ALA   B 1 141 ? -2.456  -35.841 -60.865 1.00 46.59 ? 141 ALA   B C   1 
ATOM   4103 O O   . ALA   B 1 141 ? -1.500  -36.513 -61.254 1.00 45.56 ? 141 ALA   B O   1 
ATOM   4104 C CB  . ALA   B 1 141 ? -2.946  -37.709 -59.274 1.00 45.68 ? 141 ALA   B CB  1 
ATOM   4105 N N   . ASP   B 1 142 ? -2.803  -34.709 -61.471 1.00 45.55 ? 142 ASP   B N   1 
ATOM   4106 C CA  . ASP   B 1 142 ? -2.008  -34.205 -62.583 1.00 46.80 ? 142 ASP   B CA  1 
ATOM   4107 C C   . ASP   B 1 142 ? -2.328  -32.738 -62.814 1.00 45.84 ? 142 ASP   B C   1 
ATOM   4108 O O   . ASP   B 1 142 ? -3.378  -32.237 -62.403 1.00 41.17 ? 142 ASP   B O   1 
ATOM   4109 C CB  . ASP   B 1 142 ? -2.251  -35.007 -63.867 1.00 45.21 ? 142 ASP   B CB  1 
ATOM   4110 C CG  . ASP   B 1 142 ? -1.241  -34.681 -64.955 1.00 45.23 ? 142 ASP   B CG  1 
ATOM   4111 O OD1 . ASP   B 1 142 ? -0.274  -33.945 -64.667 1.00 42.80 ? 142 ASP   B OD1 1 
ATOM   4112 O OD2 . ASP   B 1 142 ? -1.414  -35.157 -66.094 1.00 48.64 ? 142 ASP   B OD2 1 
ATOM   4113 N N   . TRP   B 1 143 ? -1.395  -32.052 -63.479 1.00 46.91 ? 143 TRP   B N   1 
ATOM   4114 C CA  . TRP   B 1 143 ? -1.615  -30.689 -63.943 1.00 44.94 ? 143 TRP   B CA  1 
ATOM   4115 C C   . TRP   B 1 143 ? -2.264  -30.640 -65.321 1.00 47.64 ? 143 TRP   B C   1 
ATOM   4116 O O   . TRP   B 1 143 ? -2.012  -29.709 -66.098 1.00 45.95 ? 143 TRP   B O   1 
ATOM   4117 C CB  . TRP   B 1 143 ? -0.309  -29.899 -63.911 1.00 45.06 ? 143 TRP   B CB  1 
ATOM   4118 C CG  . TRP   B 1 143 ? 0.022   -29.463 -62.516 1.00 46.50 ? 143 TRP   B CG  1 
ATOM   4119 C CD1 . TRP   B 1 143 ? -0.845  -29.366 -61.466 1.00 45.35 ? 143 TRP   B CD1 1 
ATOM   4120 C CD2 . TRP   B 1 143 ? 1.306   -29.084 -62.010 1.00 46.55 ? 143 TRP   B CD2 1 
ATOM   4121 N NE1 . TRP   B 1 143 ? -0.184  -28.942 -60.343 1.00 46.47 ? 143 TRP   B NE1 1 
ATOM   4122 C CE2 . TRP   B 1 143 ? 1.139   -28.761 -60.649 1.00 46.66 ? 143 TRP   B CE2 1 
ATOM   4123 C CE3 . TRP   B 1 143 ? 2.579   -28.980 -62.575 1.00 44.77 ? 143 TRP   B CE3 1 
ATOM   4124 C CZ2 . TRP   B 1 143 ? 2.197   -28.346 -59.846 1.00 46.48 ? 143 TRP   B CZ2 1 
ATOM   4125 C CZ3 . TRP   B 1 143 ? 3.628   -28.566 -61.775 1.00 48.12 ? 143 TRP   B CZ3 1 
ATOM   4126 C CH2 . TRP   B 1 143 ? 3.431   -28.255 -60.427 1.00 48.98 ? 143 TRP   B CH2 1 
ATOM   4127 N N   . GLN   B 1 144 ? -3.108  -31.625 -65.629 1.00 47.24 ? 144 GLN   B N   1 
ATOM   4128 C CA  . GLN   B 1 144 ? -3.971  -31.625 -66.801 1.00 44.98 ? 144 GLN   B CA  1 
ATOM   4129 C C   . GLN   B 1 144 ? -5.344  -32.119 -66.367 1.00 44.50 ? 144 GLN   B C   1 
ATOM   4130 O O   . GLN   B 1 144 ? -5.533  -32.556 -65.230 1.00 47.68 ? 144 GLN   B O   1 
ATOM   4131 C CB  . GLN   B 1 144 ? -3.411  -32.509 -67.923 1.00 46.99 ? 144 GLN   B CB  1 
ATOM   4132 C CG  . GLN   B 1 144 ? -1.951  -32.255 -68.255 1.00 48.73 ? 144 GLN   B CG  1 
ATOM   4133 C CD  . GLN   B 1 144 ? -1.384  -33.293 -69.202 1.00 46.97 ? 144 GLN   B CD  1 
ATOM   4134 O OE1 . GLN   B 1 144 ? -1.324  -33.081 -70.414 1.00 44.21 ? 144 GLN   B OE1 1 
ATOM   4135 N NE2 . GLN   B 1 144 ? -0.961  -34.427 -68.651 1.00 46.85 ? 144 GLN   B NE2 1 
ATOM   4136 N N   . SER   B 1 145 ? -6.311  -32.046 -67.277 1.00 47.85 ? 145 SER   B N   1 
ATOM   4137 C CA  . SER   B 1 145 ? -7.658  -32.560 -67.032 1.00 42.69 ? 145 SER   B CA  1 
ATOM   4138 C C   . SER   B 1 145 ? -8.009  -33.532 -68.153 1.00 45.71 ? 145 SER   B C   1 
ATOM   4139 O O   . SER   B 1 145 ? -8.500  -33.124 -69.210 1.00 43.05 ? 145 SER   B O   1 
ATOM   4140 C CB  . SER   B 1 145 ? -8.676  -31.430 -66.931 1.00 42.95 ? 145 SER   B CB  1 
ATOM   4141 O OG  . SER   B 1 145 ? -8.622  -30.830 -65.650 1.00 44.95 ? 145 SER   B OG  1 
ATOM   4142 N N   . VAL   B 1 146 ? -7.766  -34.818 -67.910 1.00 44.28 ? 146 VAL   B N   1 
ATOM   4143 C CA  . VAL   B 1 146 ? -8.029  -35.872 -68.885 1.00 42.79 ? 146 VAL   B CA  1 
ATOM   4144 C C   . VAL   B 1 146 ? -8.274  -37.172 -68.130 1.00 45.05 ? 146 VAL   B C   1 
ATOM   4145 O O   . VAL   B 1 146 ? -7.586  -37.476 -67.150 1.00 44.61 ? 146 VAL   B O   1 
ATOM   4146 C CB  . VAL   B 1 146 ? -6.867  -36.006 -69.895 1.00 43.08 ? 146 VAL   B CB  1 
ATOM   4147 C CG1 . VAL   B 1 146 ? -5.548  -36.256 -69.174 1.00 43.10 ? 146 VAL   B CG1 1 
ATOM   4148 C CG2 . VAL   B 1 146 ? -7.152  -37.107 -70.907 1.00 44.36 ? 146 VAL   B CG2 1 
ATOM   4149 N N   . ASN   B 1 147 ? -9.266  -37.936 -68.580 1.00 43.49 ? 147 ASN   B N   1 
ATOM   4150 C CA  . ASN   B 1 147 ? -9.653  -39.168 -67.908 1.00 43.41 ? 147 ASN   B CA  1 
ATOM   4151 C C   . ASN   B 1 147 ? -10.408 -40.041 -68.900 1.00 43.14 ? 147 ASN   B C   1 
ATOM   4152 O O   . ASN   B 1 147 ? -10.958 -39.533 -69.885 1.00 42.95 ? 147 ASN   B O   1 
ATOM   4153 C CB  . ASN   B 1 147 ? -10.516 -38.879 -66.667 1.00 42.15 ? 147 ASN   B CB  1 
ATOM   4154 C CG  . ASN   B 1 147 ? -11.839 -38.226 -67.015 1.00 43.92 ? 147 ASN   B CG  1 
ATOM   4155 O OD1 . ASN   B 1 147 ? -12.803 -38.903 -67.367 1.00 43.36 ? 147 ASN   B OD1 1 
ATOM   4156 N ND2 . ASN   B 1 147 ? -11.895 -36.903 -66.906 1.00 44.30 ? 147 ASN   B ND2 1 
ATOM   4157 N N   . PRO   B 1 148 ? -10.454 -41.358 -68.671 1.00 42.10 ? 148 PRO   B N   1 
ATOM   4158 C CA  . PRO   B 1 148 ? -11.162 -42.239 -69.614 1.00 41.96 ? 148 PRO   B CA  1 
ATOM   4159 C C   . PRO   B 1 148 ? -12.674 -42.093 -69.585 1.00 42.65 ? 148 PRO   B C   1 
ATOM   4160 O O   . PRO   B 1 148 ? -13.333 -42.515 -70.543 1.00 43.09 ? 148 PRO   B O   1 
ATOM   4161 C CB  . PRO   B 1 148 ? -10.733 -43.643 -69.169 1.00 39.92 ? 148 PRO   B CB  1 
ATOM   4162 C CG  . PRO   B 1 148 ? -10.370 -43.490 -67.737 1.00 42.09 ? 148 PRO   B CG  1 
ATOM   4163 C CD  . PRO   B 1 148 ? -9.759  -42.124 -67.621 1.00 37.90 ? 148 PRO   B CD  1 
ATOM   4164 N N   . ASN   B 1 149 ? -13.250 -41.522 -68.526 1.00 41.93 ? 149 ASN   B N   1 
ATOM   4165 C CA  . ASN   B 1 149 ? -14.702 -41.409 -68.446 1.00 41.31 ? 149 ASN   B CA  1 
ATOM   4166 C C   . ASN   B 1 149 ? -15.249 -40.305 -69.343 1.00 42.93 ? 149 ASN   B C   1 
ATOM   4167 O O   . ASN   B 1 149 ? -16.339 -40.455 -69.907 1.00 43.06 ? 149 ASN   B O   1 
ATOM   4168 C CB  . ASN   B 1 149 ? -15.137 -41.156 -67.000 1.00 43.45 ? 149 ASN   B CB  1 
ATOM   4169 C CG  . ASN   B 1 149 ? -14.875 -42.343 -66.093 1.00 44.47 ? 149 ASN   B CG  1 
ATOM   4170 O OD1 . ASN   B 1 149 ? -14.892 -43.492 -66.535 1.00 46.48 ? 149 ASN   B OD1 1 
ATOM   4171 N ND2 . ASN   B 1 149 ? -14.636 -42.071 -64.815 1.00 44.32 ? 149 ASN   B ND2 1 
ATOM   4172 N N   . TYR   B 1 150 ? -14.519 -39.200 -69.487 1.00 41.77 ? 150 TYR   B N   1 
ATOM   4173 C CA  . TYR   B 1 150 ? -15.027 -38.026 -70.186 1.00 42.24 ? 150 TYR   B CA  1 
ATOM   4174 C C   . TYR   B 1 150 ? -14.124 -37.509 -71.295 1.00 43.28 ? 150 TYR   B C   1 
ATOM   4175 O O   . TYR   B 1 150 ? -14.618 -36.795 -72.176 1.00 42.58 ? 150 TYR   B O   1 
ATOM   4176 C CB  . TYR   B 1 150 ? -15.274 -36.881 -69.191 1.00 42.98 ? 150 TYR   B CB  1 
ATOM   4177 C CG  . TYR   B 1 150 ? -16.040 -37.292 -67.953 1.00 42.48 ? 150 TYR   B CG  1 
ATOM   4178 C CD1 . TYR   B 1 150 ? -17.364 -37.696 -68.036 1.00 43.12 ? 150 TYR   B CD1 1 
ATOM   4179 C CD2 . TYR   B 1 150 ? -15.439 -37.265 -66.701 1.00 42.81 ? 150 TYR   B CD2 1 
ATOM   4180 C CE1 . TYR   B 1 150 ? -18.067 -38.074 -66.910 1.00 42.29 ? 150 TYR   B CE1 1 
ATOM   4181 C CE2 . TYR   B 1 150 ? -16.135 -37.640 -65.567 1.00 43.61 ? 150 TYR   B CE2 1 
ATOM   4182 C CZ  . TYR   B 1 150 ? -17.449 -38.045 -65.678 1.00 42.44 ? 150 TYR   B CZ  1 
ATOM   4183 O OH  . TYR   B 1 150 ? -18.147 -38.419 -64.551 1.00 42.24 ? 150 TYR   B OH  1 
ATOM   4184 N N   . GLY   B 1 151 ? -12.838 -37.823 -71.283 1.00 42.38 ? 151 GLY   B N   1 
ATOM   4185 C CA  . GLY   B 1 151 ? -11.920 -37.295 -72.266 1.00 40.64 ? 151 GLY   B CA  1 
ATOM   4186 C C   . GLY   B 1 151 ? -11.041 -36.194 -71.708 1.00 41.77 ? 151 GLY   B C   1 
ATOM   4187 O O   . GLY   B 1 151 ? -10.831 -36.066 -70.500 1.00 38.58 ? 151 GLY   B O   1 
ATOM   4188 N N   . ARG   B 1 152 ? -10.529 -35.375 -72.620 1.00 41.61 ? 152 ARG   B N   1 
ATOM   4189 C CA  . ARG   B 1 152 ? -9.543  -34.350 -72.309 1.00 40.28 ? 152 ARG   B CA  1 
ATOM   4190 C C   . ARG   B 1 152 ? -10.161 -32.960 -72.407 1.00 44.65 ? 152 ARG   B C   1 
ATOM   4191 O O   . ARG   B 1 152 ? -11.009 -32.702 -73.269 1.00 43.56 ? 152 ARG   B O   1 
ATOM   4192 C CB  . ARG   B 1 152 ? -8.350  -34.453 -73.262 1.00 40.15 ? 152 ARG   B CB  1 
ATOM   4193 C CG  . ARG   B 1 152 ? -7.141  -33.631 -72.863 1.00 43.05 ? 152 ARG   B CG  1 
ATOM   4194 C CD  . ARG   B 1 152 ? -6.095  -33.681 -73.959 1.00 43.69 ? 152 ARG   B CD  1 
ATOM   4195 N NE  . ARG   B 1 152 ? -6.523  -32.944 -75.141 1.00 43.12 ? 152 ARG   B NE  1 
ATOM   4196 C CZ  . ARG   B 1 152 ? -6.186  -33.253 -76.385 1.00 44.92 ? 152 ARG   B CZ  1 
ATOM   4197 N NH1 . ARG   B 1 152 ? -5.443  -34.314 -76.657 1.00 43.45 ? 152 ARG   B NH1 1 
ATOM   4198 N NH2 . ARG   B 1 152 ? -6.617  -32.488 -77.383 1.00 43.94 ? 152 ARG   B NH2 1 
ATOM   4199 N N   . THR   B 1 153 ? -9.730  -32.064 -71.523 1.00 44.00 ? 153 THR   B N   1 
ATOM   4200 C CA  . THR   B 1 153 ? -10.123 -30.662 -71.576 1.00 41.41 ? 153 THR   B CA  1 
ATOM   4201 C C   . THR   B 1 153 ? -8.997  -29.860 -72.212 1.00 41.51 ? 153 THR   B C   1 
ATOM   4202 O O   . THR   B 1 153 ? -7.833  -30.002 -71.825 1.00 41.27 ? 153 THR   B O   1 
ATOM   4203 C CB  . THR   B 1 153 ? -10.442 -30.117 -70.184 1.00 42.30 ? 153 THR   B CB  1 
ATOM   4204 O OG1 . THR   B 1 153 ? -11.458 -30.923 -69.580 1.00 42.23 ? 153 THR   B OG1 1 
ATOM   4205 C CG2 . THR   B 1 153 ? -10.946 -28.687 -70.280 1.00 39.77 ? 153 THR   B CG2 1 
ATOM   4206 N N   . ASN   B 1 154 ? -9.345  -29.028 -73.188 1.00 42.18 ? 154 ASN   B N   1 
ATOM   4207 C CA  . ASN   B 1 154 ? -8.375  -28.254 -73.951 1.00 42.04 ? 154 ASN   B CA  1 
ATOM   4208 C C   . ASN   B 1 154 ? -8.437  -26.792 -73.530 1.00 42.91 ? 154 ASN   B C   1 
ATOM   4209 O O   . ASN   B 1 154 ? -9.528  -26.239 -73.345 1.00 46.15 ? 154 ASN   B O   1 
ATOM   4210 C CB  . ASN   B 1 154 ? -8.635  -28.391 -75.453 1.00 43.75 ? 154 ASN   B CB  1 
ATOM   4211 C CG  . ASN   B 1 154 ? -8.800  -29.837 -75.883 1.00 42.07 ? 154 ASN   B CG  1 
ATOM   4212 O OD1 . ASN   B 1 154 ? -7.835  -30.602 -75.913 1.00 42.16 ? 154 ASN   B OD1 1 
ATOM   4213 N ND2 . ASN   B 1 154 ? -10.027 -30.218 -76.224 1.00 41.61 ? 154 ASN   B ND2 1 
ATOM   4214 N N   . ASN   B 1 155 ? -7.267  -26.180 -73.374 1.00 43.44 ? 155 ASN   B N   1 
ATOM   4215 C CA  . ASN   B 1 155 ? -7.165  -24.780 -72.988 1.00 43.87 ? 155 ASN   B CA  1 
ATOM   4216 C C   . ASN   B 1 155 ? -7.911  -23.907 -73.990 1.00 44.54 ? 155 ASN   B C   1 
ATOM   4217 O O   . ASN   B 1 155 ? -7.622  -23.976 -75.194 1.00 45.25 ? 155 ASN   B O   1 
ATOM   4218 C CB  . ASN   B 1 155 ? -5.693  -24.365 -72.904 1.00 42.08 ? 155 ASN   B CB  1 
ATOM   4219 C CG  . ASN   B 1 155 ? -5.494  -23.011 -72.237 1.00 43.29 ? 155 ASN   B CG  1 
ATOM   4220 O OD1 . ASN   B 1 155 ? -6.279  -22.084 -72.429 1.00 44.42 ? 155 ASN   B OD1 1 
ATOM   4221 N ND2 . ASN   B 1 155 ? -4.431  -22.895 -71.450 1.00 41.71 ? 155 ASN   B ND2 1 
ATOM   4222 N N   . PRO   B 1 156 ? -8.872  -23.091 -73.550 1.00 45.46 ? 156 PRO   B N   1 
ATOM   4223 C CA  . PRO   B 1 156 ? -9.612  -22.251 -74.504 1.00 43.21 ? 156 PRO   B CA  1 
ATOM   4224 C C   . PRO   B 1 156 ? -8.749  -21.218 -75.214 1.00 45.75 ? 156 PRO   B C   1 
ATOM   4225 O O   . PRO   B 1 156 ? -9.150  -20.737 -76.281 1.00 49.94 ? 156 PRO   B O   1 
ATOM   4226 C CB  . PRO   B 1 156 ? -10.679 -21.583 -73.626 1.00 43.45 ? 156 PRO   B CB  1 
ATOM   4227 C CG  . PRO   B 1 156 ? -10.811 -22.484 -72.434 1.00 40.96 ? 156 PRO   B CG  1 
ATOM   4228 C CD  . PRO   B 1 156 ? -9.429  -23.008 -72.189 1.00 41.04 ? 156 PRO   B CD  1 
ATOM   4229 N N   . HIS   B 1 157 ? -7.585  -20.861 -74.667 1.00 47.16 ? 157 HIS   B N   1 
ATOM   4230 C CA  . HIS   B 1 157 ? -6.690  -19.938 -75.351 1.00 47.18 ? 157 HIS   B CA  1 
ATOM   4231 C C   . HIS   B 1 157 ? -5.843  -20.627 -76.410 1.00 47.68 ? 157 HIS   B C   1 
ATOM   4232 O O   . HIS   B 1 157 ? -5.352  -19.954 -77.326 1.00 45.18 ? 157 HIS   B O   1 
ATOM   4233 C CB  . HIS   B 1 157 ? -5.775  -19.247 -74.338 1.00 46.54 ? 157 HIS   B CB  1 
ATOM   4234 C CG  . HIS   B 1 157 ? -6.506  -18.525 -73.255 1.00 47.99 ? 157 HIS   B CG  1 
ATOM   4235 N ND1 . HIS   B 1 157 ? -6.758  -17.172 -73.306 1.00 47.43 ? 157 HIS   B ND1 1 
ATOM   4236 C CD2 . HIS   B 1 157 ? -7.046  -18.968 -72.097 1.00 45.40 ? 157 HIS   B CD2 1 
ATOM   4237 C CE1 . HIS   B 1 157 ? -7.419  -16.811 -72.222 1.00 45.73 ? 157 HIS   B CE1 1 
ATOM   4238 N NE2 . HIS   B 1 157 ? -7.606  -17.882 -71.472 1.00 45.48 ? 157 HIS   B NE2 1 
ATOM   4239 N N   . ASP   B 1 158 ? -5.671  -21.945 -76.296 1.00 48.34 ? 158 ASP   B N   1 
ATOM   4240 C CA  . ASP   B 1 158 ? -4.887  -22.728 -77.249 1.00 47.50 ? 158 ASP   B CA  1 
ATOM   4241 C C   . ASP   B 1 158 ? -5.265  -24.188 -77.034 1.00 47.07 ? 158 ASP   B C   1 
ATOM   4242 O O   . ASP   B 1 158 ? -4.911  -24.772 -76.006 1.00 45.94 ? 158 ASP   B O   1 
ATOM   4243 C CB  . ASP   B 1 158 ? -3.390  -22.485 -77.046 1.00 47.52 ? 158 ASP   B CB  1 
ATOM   4244 C CG  . ASP   B 1 158 ? -2.520  -23.169 -78.094 1.00 46.75 ? 158 ASP   B CG  1 
ATOM   4245 O OD1 . ASP   B 1 158 ? -2.982  -24.129 -78.747 1.00 47.08 ? 158 ASP   B OD1 1 
ATOM   4246 O OD2 . ASP   B 1 158 ? -1.348  -22.763 -78.246 1.00 46.82 ? 158 ASP   B OD2 1 
ATOM   4247 N N   . HIS   B 1 159 ? -5.978  -24.764 -78.002 1.00 43.54 ? 159 HIS   B N   1 
ATOM   4248 C CA  . HIS   B 1 159 ? -6.519  -26.104 -77.838 1.00 43.75 ? 159 HIS   B CA  1 
ATOM   4249 C C   . HIS   B 1 159 ? -5.431  -27.162 -77.715 1.00 45.30 ? 159 HIS   B C   1 
ATOM   4250 O O   . HIS   B 1 159 ? -5.706  -28.265 -77.228 1.00 46.86 ? 159 HIS   B O   1 
ATOM   4251 C CB  . HIS   B 1 159 ? -7.443  -26.436 -79.007 1.00 44.59 ? 159 HIS   B CB  1 
ATOM   4252 C CG  . HIS   B 1 159 ? -8.651  -25.551 -79.095 1.00 45.49 ? 159 HIS   B CG  1 
ATOM   4253 N ND1 . HIS   B 1 159 ? -8.806  -24.412 -78.333 1.00 48.65 ? 159 HIS   B ND1 1 
ATOM   4254 C CD2 . HIS   B 1 159 ? -9.763  -25.640 -79.863 1.00 46.31 ? 159 HIS   B CD2 1 
ATOM   4255 C CE1 . HIS   B 1 159 ? -9.961  -23.840 -78.625 1.00 48.92 ? 159 HIS   B CE1 1 
ATOM   4256 N NE2 . HIS   B 1 159 ? -10.561 -24.566 -79.551 1.00 46.85 ? 159 HIS   B NE2 1 
ATOM   4257 N N   . SER   B 1 160 ? -4.203  -26.850 -78.124 1.00 43.61 ? 160 SER   B N   1 
ATOM   4258 C CA  . SER   B 1 160 ? -3.112  -27.807 -78.015 1.00 44.01 ? 160 SER   B CA  1 
ATOM   4259 C C   . SER   B 1 160 ? -2.459  -27.810 -76.640 1.00 46.65 ? 160 SER   B C   1 
ATOM   4260 O O   . SER   B 1 160 ? -1.672  -28.717 -76.350 1.00 44.44 ? 160 SER   B O   1 
ATOM   4261 C CB  . SER   B 1 160 ? -2.054  -27.524 -79.084 1.00 44.37 ? 160 SER   B CB  1 
ATOM   4262 O OG  . SER   B 1 160 ? -1.393  -26.294 -78.842 1.00 46.71 ? 160 SER   B OG  1 
ATOM   4263 N N   . ARG   B 1 161 ? -2.762  -26.832 -75.794 1.00 45.13 ? 161 ARG   B N   1 
ATOM   4264 C CA  . ARG   B 1 161 ? -2.170  -26.729 -74.469 1.00 46.47 ? 161 ARG   B CA  1 
ATOM   4265 C C   . ARG   B 1 161 ? -3.136  -27.254 -73.413 1.00 44.73 ? 161 ARG   B C   1 
ATOM   4266 O O   . ARG   B 1 161 ? -4.355  -27.265 -73.601 1.00 46.02 ? 161 ARG   B O   1 
ATOM   4267 C CB  . ARG   B 1 161 ? -1.787  -25.280 -74.151 1.00 46.07 ? 161 ARG   B CB  1 
ATOM   4268 C CG  . ARG   B 1 161 ? -1.114  -24.546 -75.297 1.00 46.79 ? 161 ARG   B CG  1 
ATOM   4269 C CD  . ARG   B 1 161 ? 0.147   -25.246 -75.772 1.00 48.15 ? 161 ARG   B CD  1 
ATOM   4270 N NE  . ARG   B 1 161 ? 1.262   -25.062 -74.851 1.00 53.94 ? 161 ARG   B NE  1 
ATOM   4271 C CZ  . ARG   B 1 161 ? 2.525   -25.350 -75.138 1.00 54.10 ? 161 ARG   B CZ  1 
ATOM   4272 N NH1 . ARG   B 1 161 ? 2.871   -25.833 -76.320 1.00 52.61 ? 161 ARG   B NH1 1 
ATOM   4273 N NH2 . ARG   B 1 161 ? 3.464   -25.141 -74.220 1.00 53.26 ? 161 ARG   B NH2 1 
ATOM   4274 N N   . SER   B 1 162 ? -2.571  -27.691 -72.289 1.00 47.19 ? 162 SER   B N   1 
ATOM   4275 C CA  . SER   B 1 162 ? -3.379  -28.219 -71.199 1.00 45.53 ? 162 SER   B CA  1 
ATOM   4276 C C   . SER   B 1 162 ? -4.223  -27.116 -70.571 1.00 44.36 ? 162 SER   B C   1 
ATOM   4277 O O   . SER   B 1 162 ? -3.811  -25.954 -70.507 1.00 42.72 ? 162 SER   B O   1 
ATOM   4278 C CB  . SER   B 1 162 ? -2.484  -28.864 -70.144 1.00 44.51 ? 162 SER   B CB  1 
ATOM   4279 O OG  . SER   B 1 162 ? -3.248  -29.349 -69.054 1.00 46.47 ? 162 SER   B OG  1 
ATOM   4280 N N   . ALA   B 1 163 ? -5.413  -27.487 -70.100 1.00 45.24 ? 163 ALA   B N   1 
ATOM   4281 C CA  . ALA   B 1 163 ? -6.331  -26.516 -69.518 1.00 43.54 ? 163 ALA   B CA  1 
ATOM   4282 C C   . ALA   B 1 163 ? -6.056  -26.240 -68.047 1.00 44.75 ? 163 ALA   B C   1 
ATOM   4283 O O   . ALA   B 1 163 ? -6.702  -25.360 -67.469 1.00 48.06 ? 163 ALA   B O   1 
ATOM   4284 C CB  . ALA   B 1 163 ? -7.776  -26.993 -69.679 1.00 40.04 ? 163 ALA   B CB  1 
ATOM   4285 N N   . GLY   B 1 164 ? -5.123  -26.949 -67.433 1.00 43.76 ? 164 GLY   B N   1 
ATOM   4286 C CA  . GLY   B 1 164 ? -4.895  -26.856 -66.007 1.00 45.37 ? 164 GLY   B CA  1 
ATOM   4287 C C   . GLY   B 1 164 ? -5.158  -28.181 -65.312 1.00 46.54 ? 164 GLY   B C   1 
ATOM   4288 O O   . GLY   B 1 164 ? -5.742  -29.112 -65.867 1.00 45.30 ? 164 GLY   B O   1 
ATOM   4289 N N   . GLY   B 1 165 ? -4.727  -28.245 -64.063 1.00 48.88 ? 165 GLY   B N   1 
ATOM   4290 C CA  . GLY   B 1 165 ? -4.645  -29.503 -63.336 1.00 49.04 ? 165 GLY   B CA  1 
ATOM   4291 C C   . GLY   B 1 165 ? -5.636  -29.642 -62.201 1.00 48.99 ? 165 GLY   B C   1 
ATOM   4292 O O   . GLY   B 1 165 ? -5.812  -28.721 -61.399 1.00 49.39 ? 165 GLY   B O   1 
ATOM   4293 N N   . SER   B 1 166 ? -6.236  -30.829 -62.107 1.00 52.56 ? 166 SER   B N   1 
ATOM   4294 C CA  . SER   B 1 166 ? -7.264  -31.153 -61.129 1.00 42.24 ? 166 SER   B CA  1 
ATOM   4295 C C   . SER   B 1 166 ? -8.513  -30.310 -61.369 1.00 43.95 ? 166 SER   B C   1 
ATOM   4296 O O   . SER   B 1 166 ? -9.556  -30.848 -61.741 1.00 46.83 ? 166 SER   B O   1 
ATOM   4297 C CB  . SER   B 1 166 ? -6.726  -31.002 -59.713 1.00 48.24 ? 166 SER   B CB  1 
ATOM   4298 O OG  . SER   B 1 166 ? -7.632  -31.534 -58.770 1.00 50.48 ? 166 SER   B OG  1 
ATOM   4299 N N   . SER   B 1 167 ? -8.429  -28.996 -61.194 1.00 43.01 ? 167 SER   B N   1 
ATOM   4300 C CA  . SER   B 1 167 ? -9.560  -28.121 -61.489 1.00 44.20 ? 167 SER   B CA  1 
ATOM   4301 C C   . SER   B 1 167 ? -9.457  -27.507 -62.877 1.00 42.86 ? 167 SER   B C   1 
ATOM   4302 O O   . SER   B 1 167 ? -9.773  -26.327 -63.076 1.00 42.43 ? 167 SER   B O   1 
ATOM   4303 C CB  . SER   B 1 167 ? -9.687  -27.039 -60.427 1.00 43.14 ? 167 SER   B CB  1 
ATOM   4304 O OG  . SER   B 1 167 ? -9.652  -27.596 -59.124 1.00 39.77 ? 167 SER   B OG  1 
ATOM   4305 N N   . GLY   B 1 168 ? -9.013  -28.286 -63.860 1.00 42.44 ? 168 GLY   B N   1 
ATOM   4306 C CA  . GLY   B 1 168 ? -8.867  -27.782 -65.215 1.00 44.06 ? 168 GLY   B CA  1 
ATOM   4307 C C   . GLY   B 1 168 ? -10.173 -27.512 -65.935 1.00 41.30 ? 168 GLY   B C   1 
ATOM   4308 O O   . GLY   B 1 168 ? -10.292 -26.492 -66.621 1.00 40.35 ? 168 GLY   B O   1 
ATOM   4309 N N   . GLY   B 1 169 ? -11.156 -28.409 -65.813 1.00 41.72 ? 169 GLY   B N   1 
ATOM   4310 C CA  . GLY   B 1 169 ? -12.441 -28.153 -66.441 1.00 39.14 ? 169 GLY   B CA  1 
ATOM   4311 C C   . GLY   B 1 169 ? -13.142 -26.934 -65.873 1.00 42.58 ? 169 GLY   B C   1 
ATOM   4312 O O   . GLY   B 1 169 ? -13.907 -26.266 -66.574 1.00 41.64 ? 169 GLY   B O   1 
ATOM   4313 N N   . ALA   B 1 170 ? -12.907 -26.637 -64.594 1.00 42.74 ? 170 ALA   B N   1 
ATOM   4314 C CA  . ALA   B 1 170 ? -13.480 -25.444 -63.978 1.00 41.82 ? 170 ALA   B CA  1 
ATOM   4315 C C   . ALA   B 1 170 ? -12.900 -24.175 -64.591 1.00 40.45 ? 170 ALA   B C   1 
ATOM   4316 O O   . ALA   B 1 170 ? -13.635 -23.238 -64.923 1.00 39.09 ? 170 ALA   B O   1 
ATOM   4317 C CB  . ALA   B 1 170 ? -13.237 -25.472 -62.466 1.00 41.11 ? 170 ALA   B CB  1 
ATOM   4318 N N   . ALA   B 1 171 ? -11.575 -24.125 -64.747 1.00 41.55 ? 171 ALA   B N   1 
ATOM   4319 C CA  . ALA   B 1 171 ? -10.945 -22.927 -65.292 1.00 40.35 ? 171 ALA   B CA  1 
ATOM   4320 C C   . ALA   B 1 171 ? -11.251 -22.750 -66.772 1.00 41.29 ? 171 ALA   B C   1 
ATOM   4321 O O   . ALA   B 1 171 ? -11.376 -21.614 -67.245 1.00 40.17 ? 171 ALA   B O   1 
ATOM   4322 C CB  . ALA   B 1 171 ? -9.436  -22.976 -65.063 1.00 39.92 ? 171 ALA   B CB  1 
ATOM   4323 N N   . ALA   B 1 172 ? -11.374 -23.850 -67.517 1.00 42.45 ? 172 ALA   B N   1 
ATOM   4324 C CA  . ALA   B 1 172 ? -11.705 -23.747 -68.934 1.00 39.62 ? 172 ALA   B CA  1 
ATOM   4325 C C   . ALA   B 1 172 ? -13.123 -23.227 -69.133 1.00 41.34 ? 172 ALA   B C   1 
ATOM   4326 O O   . ALA   B 1 172 ? -13.375 -22.422 -70.038 1.00 43.91 ? 172 ALA   B O   1 
ATOM   4327 C CB  . ALA   B 1 172 ? -11.531 -25.105 -69.616 1.00 40.50 ? 172 ALA   B CB  1 
ATOM   4328 N N   . ALA   B 1 173 ? -14.063 -23.671 -68.295 1.00 39.94 ? 173 ALA   B N   1 
ATOM   4329 C CA  . ALA   B 1 173 ? -15.436 -23.192 -68.407 1.00 42.24 ? 173 ALA   B CA  1 
ATOM   4330 C C   . ALA   B 1 173 ? -15.539 -21.713 -68.069 1.00 41.75 ? 173 ALA   B C   1 
ATOM   4331 O O   . ALA   B 1 173 ? -16.385 -21.007 -68.629 1.00 43.10 ? 173 ALA   B O   1 
ATOM   4332 C CB  . ALA   B 1 173 ? -16.354 -24.011 -67.501 1.00 39.61 ? 173 ALA   B CB  1 
ATOM   4333 N N   . LEU   B 1 174 ? -14.686 -21.228 -67.163 1.00 40.86 ? 174 LEU   B N   1 
ATOM   4334 C CA  . LEU   B 1 174 ? -14.700 -19.811 -66.814 1.00 39.72 ? 174 LEU   B CA  1 
ATOM   4335 C C   . LEU   B 1 174 ? -14.087 -18.958 -67.918 1.00 40.89 ? 174 LEU   B C   1 
ATOM   4336 O O   . LEU   B 1 174 ? -14.603 -17.879 -68.234 1.00 43.08 ? 174 LEU   B O   1 
ATOM   4337 C CB  . LEU   B 1 174 ? -13.961 -19.587 -65.493 1.00 39.48 ? 174 LEU   B CB  1 
ATOM   4338 C CG  . LEU   B 1 174 ? -14.628 -20.139 -64.230 1.00 41.95 ? 174 LEU   B CG  1 
ATOM   4339 C CD1 . LEU   B 1 174 ? -13.687 -20.044 -63.036 1.00 40.66 ? 174 LEU   B CD1 1 
ATOM   4340 C CD2 . LEU   B 1 174 ? -15.925 -19.402 -63.951 1.00 41.12 ? 174 LEU   B CD2 1 
ATOM   4341 N N   . ALA   B 1 175 ? -12.984 -19.418 -68.513 1.00 39.56 ? 175 ALA   B N   1 
ATOM   4342 C CA  . ALA   B 1 175 ? -12.324 -18.632 -69.550 1.00 41.71 ? 175 ALA   B CA  1 
ATOM   4343 C C   . ALA   B 1 175 ? -13.146 -18.577 -70.830 1.00 44.56 ? 175 ALA   B C   1 
ATOM   4344 O O   . ALA   B 1 175 ? -13.029 -17.616 -71.597 1.00 42.94 ? 175 ALA   B O   1 
ATOM   4345 C CB  . ALA   B 1 175 ? -10.931 -19.196 -69.833 1.00 41.06 ? 175 ALA   B CB  1 
ATOM   4346 N N   . ALA   B 1 176 ? -13.975 -19.586 -71.077 1.00 43.79 ? 176 ALA   B N   1 
ATOM   4347 C CA  . ALA   B 1 176 ? -14.810 -19.628 -72.270 1.00 38.89 ? 176 ALA   B CA  1 
ATOM   4348 C C   . ALA   B 1 176 ? -16.167 -18.961 -72.074 1.00 41.97 ? 176 ALA   B C   1 
ATOM   4349 O O   . ALA   B 1 176 ? -16.977 -18.954 -73.008 1.00 43.08 ? 176 ALA   B O   1 
ATOM   4350 C CB  . ALA   B 1 176 ? -15.007 -21.077 -72.725 1.00 39.69 ? 176 ALA   B CB  1 
ATOM   4351 N N   . GLY   B 1 177 ? -16.434 -18.408 -70.893 1.00 41.90 ? 177 GLY   B N   1 
ATOM   4352 C CA  . GLY   B 1 177 ? -17.683 -17.711 -70.662 1.00 41.68 ? 177 GLY   B CA  1 
ATOM   4353 C C   . GLY   B 1 177 ? -18.898 -18.602 -70.562 1.00 44.55 ? 177 GLY   B C   1 
ATOM   4354 O O   . GLY   B 1 177 ? -20.019 -18.126 -70.763 1.00 47.49 ? 177 GLY   B O   1 
ATOM   4355 N N   . MET   B 1 178 ? -18.708 -19.890 -70.252 1.00 42.90 ? 178 MET   B N   1 
ATOM   4356 C CA  . MET   B 1 178 ? -19.844 -20.798 -70.113 1.00 44.38 ? 178 MET   B CA  1 
ATOM   4357 C C   . MET   B 1 178 ? -20.619 -20.515 -68.831 1.00 42.18 ? 178 MET   B C   1 
ATOM   4358 O O   . MET   B 1 178 ? -21.832 -20.283 -68.865 1.00 40.46 ? 178 MET   B O   1 
ATOM   4359 C CB  . MET   B 1 178 ? -19.373 -22.256 -70.150 1.00 42.80 ? 178 MET   B CB  1 
ATOM   4360 C CG  . MET   B 1 178 ? -18.470 -22.595 -71.322 1.00 47.67 ? 178 MET   B CG  1 
ATOM   4361 S SD  . MET   B 1 178 ? -18.079 -24.355 -71.424 1.00 52.17 ? 178 MET   B SD  1 
ATOM   4362 C CE  . MET   B 1 178 ? -16.829 -24.356 -72.709 1.00 45.68 ? 178 MET   B CE  1 
ATOM   4363 N N   . VAL   B 1 179 ? -19.935 -20.533 -67.689 1.00 41.85 ? 179 VAL   B N   1 
ATOM   4364 C CA  . VAL   B 1 179 ? -20.546 -20.244 -66.395 1.00 42.21 ? 179 VAL   B CA  1 
ATOM   4365 C C   . VAL   B 1 179 ? -19.686 -19.205 -65.677 1.00 44.20 ? 179 VAL   B C   1 
ATOM   4366 O O   . VAL   B 1 179 ? -18.481 -19.084 -65.948 1.00 44.11 ? 179 VAL   B O   1 
ATOM   4367 C CB  . VAL   B 1 179 ? -20.704 -21.517 -65.533 1.00 42.38 ? 179 VAL   B CB  1 
ATOM   4368 C CG1 . VAL   B 1 179 ? -21.643 -22.503 -66.229 1.00 43.41 ? 179 VAL   B CG1 1 
ATOM   4369 C CG2 . VAL   B 1 179 ? -19.354 -22.160 -65.277 1.00 41.52 ? 179 VAL   B CG2 1 
ATOM   4370 N N   . PRO   B 1 180 ? -20.292 -18.417 -64.786 1.00 41.64 ? 180 PRO   B N   1 
ATOM   4371 C CA  . PRO   B 1 180 ? -19.557 -17.330 -64.132 1.00 40.43 ? 180 PRO   B CA  1 
ATOM   4372 C C   . PRO   B 1 180 ? -18.876 -17.675 -62.818 1.00 45.33 ? 180 PRO   B C   1 
ATOM   4373 O O   . PRO   B 1 180 ? -18.044 -16.879 -62.356 1.00 45.04 ? 180 PRO   B O   1 
ATOM   4374 C CB  . PRO   B 1 180 ? -20.654 -16.280 -63.910 1.00 40.53 ? 180 PRO   B CB  1 
ATOM   4375 C CG  . PRO   B 1 180 ? -21.857 -17.116 -63.600 1.00 41.56 ? 180 PRO   B CG  1 
ATOM   4376 C CD  . PRO   B 1 180 ? -21.733 -18.315 -64.528 1.00 40.83 ? 180 PRO   B CD  1 
ATOM   4377 N N   . LEU   B 1 181 ? -19.176 -18.822 -62.217 1.00 43.93 ? 181 LEU   B N   1 
ATOM   4378 C CA  . LEU   B 1 181 ? -18.605 -19.184 -60.931 1.00 44.90 ? 181 LEU   B CA  1 
ATOM   4379 C C   . LEU   B 1 181 ? -18.326 -20.679 -60.881 1.00 44.35 ? 181 LEU   B C   1 
ATOM   4380 O O   . LEU   B 1 181 ? -19.092 -21.484 -61.421 1.00 44.17 ? 181 LEU   B O   1 
ATOM   4381 C CB  . LEU   B 1 181 ? -19.545 -18.786 -59.787 1.00 46.61 ? 181 LEU   B CB  1 
ATOM   4382 C CG  . LEU   B 1 181 ? -19.008 -18.837 -58.349 1.00 43.76 ? 181 LEU   B CG  1 
ATOM   4383 C CD1 . LEU   B 1 181 ? -17.661 -18.166 -58.247 1.00 44.16 ? 181 LEU   B CD1 1 
ATOM   4384 C CD2 . LEU   B 1 181 ? -19.976 -18.202 -57.345 1.00 44.78 ? 181 LEU   B CD2 1 
ATOM   4385 N N   . GLU   B 1 182 ? -17.228 -21.041 -60.217 1.00 45.22 ? 182 GLU   B N   1 
ATOM   4386 C CA  . GLU   B 1 182 ? -16.817 -22.431 -60.080 1.00 42.57 ? 182 GLU   B CA  1 
ATOM   4387 C C   . GLU   B 1 182 ? -16.257 -22.669 -58.681 1.00 41.08 ? 182 GLU   B C   1 
ATOM   4388 O O   . GLU   B 1 182 ? -16.207 -21.764 -57.842 1.00 38.94 ? 182 GLU   B O   1 
ATOM   4389 C CB  . GLU   B 1 182 ? -15.794 -22.800 -61.156 1.00 42.07 ? 182 GLU   B CB  1 
ATOM   4390 C CG  . GLU   B 1 182 ? -16.394 -23.494 -62.370 1.00 46.97 ? 182 GLU   B CG  1 
ATOM   4391 C CD  . GLU   B 1 182 ? -16.603 -24.977 -62.159 1.00 49.93 ? 182 GLU   B CD  1 
ATOM   4392 O OE1 . GLU   B 1 182 ? -16.395 -25.453 -61.029 1.00 45.58 ? 182 GLU   B OE1 1 
ATOM   4393 O OE2 . GLU   B 1 182 ? -16.962 -25.672 -63.130 1.00 48.73 ? 182 GLU   B OE2 1 
ATOM   4394 N N   . TYR   B 1 183 ? -15.830 -23.907 -58.431 1.00 40.26 ? 183 TYR   B N   1 
ATOM   4395 C CA  . TYR   B 1 183 ? -15.275 -24.273 -57.133 1.00 41.16 ? 183 TYR   B CA  1 
ATOM   4396 C C   . TYR   B 1 183 ? -14.427 -25.524 -57.293 1.00 40.94 ? 183 TYR   B C   1 
ATOM   4397 O O   . TYR   B 1 183 ? -14.883 -26.509 -57.880 1.00 43.09 ? 183 TYR   B O   1 
ATOM   4398 C CB  . TYR   B 1 183 ? -16.386 -24.517 -56.108 1.00 40.67 ? 183 TYR   B CB  1 
ATOM   4399 C CG  . TYR   B 1 183 ? -16.069 -24.018 -54.716 1.00 39.18 ? 183 TYR   B CG  1 
ATOM   4400 C CD1 . TYR   B 1 183 ? -15.260 -24.750 -53.857 1.00 37.35 ? 183 TYR   B CD1 1 
ATOM   4401 C CD2 . TYR   B 1 183 ? -16.596 -22.819 -54.256 1.00 39.37 ? 183 TYR   B CD2 1 
ATOM   4402 C CE1 . TYR   B 1 183 ? -14.977 -24.294 -52.579 1.00 38.07 ? 183 TYR   B CE1 1 
ATOM   4403 C CE2 . TYR   B 1 183 ? -16.322 -22.357 -52.981 1.00 39.66 ? 183 TYR   B CE2 1 
ATOM   4404 C CZ  . TYR   B 1 183 ? -15.510 -23.095 -52.148 1.00 39.55 ? 183 TYR   B CZ  1 
ATOM   4405 O OH  . TYR   B 1 183 ? -15.237 -22.627 -50.883 1.00 36.76 ? 183 TYR   B OH  1 
ATOM   4406 N N   . GLY   B 1 184 ? -13.202 -25.485 -56.774 1.00 37.42 ? 184 GLY   B N   1 
ATOM   4407 C CA  . GLY   B 1 184 ? -12.320 -26.631 -56.868 1.00 38.26 ? 184 GLY   B CA  1 
ATOM   4408 C C   . GLY   B 1 184 ? -11.640 -26.965 -55.557 1.00 38.76 ? 184 GLY   B C   1 
ATOM   4409 O O   . GLY   B 1 184 ? -11.920 -26.345 -54.526 1.00 40.79 ? 184 GLY   B O   1 
ATOM   4410 N N   . SER   B 1 185 ? -10.758 -27.958 -55.583 1.00 37.52 ? 185 SER   B N   1 
ATOM   4411 C CA  . SER   B 1 185 ? -9.929  -28.317 -54.445 1.00 41.79 ? 185 SER   B CA  1 
ATOM   4412 C C   . SER   B 1 185 ? -8.478  -28.007 -54.785 1.00 46.05 ? 185 SER   B C   1 
ATOM   4413 O O   . SER   B 1 185 ? -8.164  -27.593 -55.899 1.00 42.81 ? 185 SER   B O   1 
ATOM   4414 C CB  . SER   B 1 185 ? -10.104 -29.794 -54.074 1.00 42.71 ? 185 SER   B CB  1 
ATOM   4415 O OG  . SER   B 1 185 ? -9.865  -30.636 -55.189 1.00 46.20 ? 185 SER   B OG  1 
ATOM   4416 N N   . ASP   B 1 186 ? -7.584  -28.205 -53.815 1.00 43.39 ? 186 ASP   B N   1 
ATOM   4417 C CA  . ASP   B 1 186 ? -6.173  -27.882 -54.031 1.00 45.19 ? 186 ASP   B CA  1 
ATOM   4418 C C   . ASP   B 1 186 ? -5.322  -28.600 -52.992 1.00 44.19 ? 186 ASP   B C   1 
ATOM   4419 O O   . ASP   B 1 186 ? -5.376  -28.258 -51.808 1.00 46.67 ? 186 ASP   B O   1 
ATOM   4420 C CB  . ASP   B 1 186 ? -5.949  -26.371 -53.972 1.00 43.35 ? 186 ASP   B CB  1 
ATOM   4421 C CG  . ASP   B 1 186 ? -4.568  -25.958 -54.469 1.00 45.17 ? 186 ASP   B CG  1 
ATOM   4422 O OD1 . ASP   B 1 186 ? -3.563  -26.586 -54.074 1.00 47.81 ? 186 ASP   B OD1 1 
ATOM   4423 O OD2 . ASP   B 1 186 ? -4.485  -24.997 -55.261 1.00 38.26 ? 186 ASP   B OD2 1 
ATOM   4424 N N   . ILE   B 1 187 ? -4.534  -29.575 -53.440 1.00 44.98 ? 187 ILE   B N   1 
ATOM   4425 C CA  . ILE   B 1 187 ? -3.495  -30.165 -52.607 1.00 45.69 ? 187 ILE   B CA  1 
ATOM   4426 C C   . ILE   B 1 187 ? -2.098  -29.949 -53.171 1.00 47.31 ? 187 ILE   B C   1 
ATOM   4427 O O   . ILE   B 1 187 ? -1.118  -30.062 -52.417 1.00 44.36 ? 187 ILE   B O   1 
ATOM   4428 C CB  . ILE   B 1 187 ? -3.747  -31.670 -52.376 1.00 46.58 ? 187 ILE   B CB  1 
ATOM   4429 C CG1 . ILE   B 1 187 ? -3.107  -32.120 -51.061 1.00 42.74 ? 187 ILE   B CG1 1 
ATOM   4430 C CG2 . ILE   B 1 187 ? -3.187  -32.491 -53.523 1.00 45.58 ? 187 ILE   B CG2 1 
ATOM   4431 C CD1 . ILE   B 1 187 ? -3.191  -33.610 -50.823 1.00 44.08 ? 187 ILE   B CD1 1 
ATOM   4432 N N   . GLY   B 1 188 ? -1.961  -29.642 -54.458 1.00 47.62 ? 188 GLY   B N   1 
ATOM   4433 C CA  . GLY   B 1 188 ? -0.673  -29.355 -55.054 1.00 45.40 ? 188 GLY   B CA  1 
ATOM   4434 C C   . GLY   B 1 188 ? -0.778  -28.300 -56.135 1.00 47.73 ? 188 GLY   B C   1 
ATOM   4435 O O   . GLY   B 1 188 ? -0.114  -28.391 -57.172 1.00 48.24 ? 188 GLY   B O   1 
ATOM   4436 N N   . GLY   B 1 189 ? -1.609  -27.292 -55.896 1.00 45.41 ? 189 GLY   B N   1 
ATOM   4437 C CA  . GLY   B 1 189 ? -1.860  -26.247 -56.865 1.00 41.54 ? 189 GLY   B CA  1 
ATOM   4438 C C   . GLY   B 1 189 ? -3.089  -26.443 -57.719 1.00 41.45 ? 189 GLY   B C   1 
ATOM   4439 O O   . GLY   B 1 189 ? -3.169  -25.851 -58.801 1.00 42.29 ? 189 GLY   B O   1 
ATOM   4440 N N   . ALA   B 1 190 ? -4.052  -27.241 -57.262 1.00 43.19 ? 190 ALA   B N   1 
ATOM   4441 C CA  . ALA   B 1 190 ? -5.176  -27.621 -58.103 1.00 44.49 ? 190 ALA   B CA  1 
ATOM   4442 C C   . ALA   B 1 190 ? -6.098  -26.456 -58.423 1.00 40.12 ? 190 ALA   B C   1 
ATOM   4443 O O   . ALA   B 1 190 ? -6.849  -26.535 -59.396 1.00 41.25 ? 190 ALA   B O   1 
ATOM   4444 C CB  . ALA   B 1 190 ? -5.958  -28.739 -57.430 1.00 46.89 ? 190 ALA   B CB  1 
ATOM   4445 N N   . ILE   B 1 191 ? -6.062  -25.387 -57.636 1.00 38.92 ? 191 ILE   B N   1 
ATOM   4446 C CA  . ILE   B 1 191 ? -6.857  -24.198 -57.907 1.00 41.09 ? 191 ILE   B CA  1 
ATOM   4447 C C   . ILE   B 1 191 ? -6.025  -23.111 -58.577 1.00 40.10 ? 191 ILE   B C   1 
ATOM   4448 O O   . ILE   B 1 191 ? -6.494  -22.451 -59.504 1.00 40.59 ? 191 ILE   B O   1 
ATOM   4449 C CB  . ILE   B 1 191 ? -7.501  -23.690 -56.598 1.00 38.59 ? 191 ILE   B CB  1 
ATOM   4450 C CG1 . ILE   B 1 191 ? -8.587  -24.661 -56.140 1.00 38.44 ? 191 ILE   B CG1 1 
ATOM   4451 C CG2 . ILE   B 1 191 ? -8.094  -22.304 -56.775 1.00 36.74 ? 191 ILE   B CG2 1 
ATOM   4452 C CD1 . ILE   B 1 191 ? -9.119  -24.407 -54.750 1.00 41.00 ? 191 ILE   B CD1 1 
ATOM   4453 N N   . ARG   B 1 192 ? -4.775  -22.946 -58.138 1.00 40.36 ? 192 ARG   B N   1 
ATOM   4454 C CA  . ARG   B 1 192 ? -3.931  -21.873 -58.652 1.00 41.94 ? 192 ARG   B CA  1 
ATOM   4455 C C   . ARG   B 1 192 ? -3.442  -22.171 -60.069 1.00 40.06 ? 192 ARG   B C   1 
ATOM   4456 O O   . ARG   B 1 192 ? -3.446  -21.281 -60.926 1.00 38.71 ? 192 ARG   B O   1 
ATOM   4457 C CB  . ARG   B 1 192 ? -2.747  -21.650 -57.711 1.00 41.40 ? 192 ARG   B CB  1 
ATOM   4458 C CG  . ARG   B 1 192 ? -3.142  -21.148 -56.336 1.00 38.20 ? 192 ARG   B CG  1 
ATOM   4459 C CD  . ARG   B 1 192 ? -2.009  -21.334 -55.339 1.00 38.25 ? 192 ARG   B CD  1 
ATOM   4460 N NE  . ARG   B 1 192 ? -1.832  -22.732 -54.965 1.00 39.97 ? 192 ARG   B NE  1 
ATOM   4461 C CZ  . ARG   B 1 192 ? -0.913  -23.169 -54.117 1.00 42.23 ? 192 ARG   B CZ  1 
ATOM   4462 N NH1 . ARG   B 1 192 ? -0.058  -22.342 -53.541 1.00 39.11 ? 192 ARG   B NH1 1 
ATOM   4463 N NH2 . ARG   B 1 192 ? -0.852  -24.468 -53.838 1.00 42.00 ? 192 ARG   B NH2 1 
ATOM   4464 N N   . VAL   B 1 193 ? -3.015  -23.404 -60.341 1.00 42.37 ? 193 VAL   B N   1 
ATOM   4465 C CA  . VAL   B 1 193 ? -2.438  -23.756 -61.642 1.00 39.10 ? 193 VAL   B CA  1 
ATOM   4466 C C   . VAL   B 1 193 ? -3.468  -23.677 -62.768 1.00 41.93 ? 193 VAL   B C   1 
ATOM   4467 O O   . VAL   B 1 193 ? -3.170  -23.090 -63.818 1.00 40.77 ? 193 VAL   B O   1 
ATOM   4468 C CB  . VAL   B 1 193 ? -1.789  -25.147 -61.607 1.00 41.03 ? 193 VAL   B CB  1 
ATOM   4469 C CG1 . VAL   B 1 193 ? -1.417  -25.584 -63.011 1.00 41.99 ? 193 VAL   B CG1 1 
ATOM   4470 C CG2 . VAL   B 1 193 ? -0.575  -25.150 -60.680 1.00 40.95 ? 193 VAL   B CG2 1 
ATOM   4471 N N   . PRO   B 1 194 ? -4.671  -24.253 -62.633 1.00 42.93 ? 194 PRO   B N   1 
ATOM   4472 C CA  . PRO   B 1 194 ? -5.648  -24.112 -63.731 1.00 40.76 ? 194 PRO   B CA  1 
ATOM   4473 C C   . PRO   B 1 194 ? -6.085  -22.678 -63.954 1.00 41.92 ? 194 PRO   B C   1 
ATOM   4474 O O   . PRO   B 1 194 ? -6.250  -22.250 -65.104 1.00 43.28 ? 194 PRO   B O   1 
ATOM   4475 C CB  . PRO   B 1 194 ? -6.821  -25.000 -63.277 1.00 42.63 ? 194 PRO   B CB  1 
ATOM   4476 C CG  . PRO   B 1 194 ? -6.221  -25.944 -62.336 1.00 45.52 ? 194 PRO   B CG  1 
ATOM   4477 C CD  . PRO   B 1 194 ? -5.168  -25.187 -61.610 1.00 40.99 ? 194 PRO   B CD  1 
ATOM   4478 N N   . ALA   B 1 195 ? -6.279  -21.919 -62.874 1.00 40.79 ? 195 ALA   B N   1 
ATOM   4479 C CA  . ALA   B 1 195 ? -6.547  -20.494 -63.014 1.00 42.92 ? 195 ALA   B CA  1 
ATOM   4480 C C   . ALA   B 1 195 ? -5.392  -19.782 -63.700 1.00 38.83 ? 195 ALA   B C   1 
ATOM   4481 O O   . ALA   B 1 195 ? -5.608  -18.792 -64.410 1.00 40.37 ? 195 ALA   B O   1 
ATOM   4482 C CB  . ALA   B 1 195 ? -6.824  -19.869 -61.645 1.00 39.31 ? 195 ALA   B CB  1 
ATOM   4483 N N   . HIS   B 1 196 ? -4.165  -20.277 -63.511 1.00 38.66 ? 196 HIS   B N   1 
ATOM   4484 C CA  . HIS   B 1 196 ? -3.012  -19.684 -64.179 1.00 39.42 ? 196 HIS   B CA  1 
ATOM   4485 C C   . HIS   B 1 196 ? -2.984  -20.049 -65.659 1.00 42.91 ? 196 HIS   B C   1 
ATOM   4486 O O   . HIS   B 1 196 ? -2.749  -19.191 -66.519 1.00 43.74 ? 196 HIS   B O   1 
ATOM   4487 C CB  . HIS   B 1 196 ? -1.729  -20.135 -63.483 1.00 40.97 ? 196 HIS   B CB  1 
ATOM   4488 C CG  . HIS   B 1 196 ? -0.488  -19.920 -64.295 1.00 39.64 ? 196 HIS   B CG  1 
ATOM   4489 N ND1 . HIS   B 1 196 ? -0.166  -18.707 -64.863 1.00 42.07 ? 196 HIS   B ND1 1 
ATOM   4490 C CD2 . HIS   B 1 196 ? 0.514   -20.768 -64.631 1.00 41.05 ? 196 HIS   B CD2 1 
ATOM   4491 C CE1 . HIS   B 1 196 ? 0.980   -18.815 -65.512 1.00 45.15 ? 196 HIS   B CE1 1 
ATOM   4492 N NE2 . HIS   B 1 196 ? 1.413   -20.056 -65.388 1.00 43.44 ? 196 HIS   B NE2 1 
ATOM   4493 N N   . PHE   B 1 197 ? -3.245  -21.319 -65.972 1.00 40.28 ? 197 PHE   B N   1 
ATOM   4494 C CA  . PHE   B 1 197 ? -3.188  -21.776 -67.355 1.00 39.60 ? 197 PHE   B CA  1 
ATOM   4495 C C   . PHE   B 1 197 ? -4.319  -21.199 -68.197 1.00 42.09 ? 197 PHE   B C   1 
ATOM   4496 O O   . PHE   B 1 197 ? -4.170  -21.059 -69.417 1.00 41.13 ? 197 PHE   B O   1 
ATOM   4497 C CB  . PHE   B 1 197 ? -3.224  -23.305 -67.404 1.00 39.35 ? 197 PHE   B CB  1 
ATOM   4498 C CG  . PHE   B 1 197 ? -1.913  -23.960 -67.062 1.00 40.76 ? 197 PHE   B CG  1 
ATOM   4499 C CD1 . PHE   B 1 197 ? -0.797  -23.200 -66.746 1.00 41.63 ? 197 PHE   B CD1 1 
ATOM   4500 C CD2 . PHE   B 1 197 ? -1.793  -25.339 -67.081 1.00 41.96 ? 197 PHE   B CD2 1 
ATOM   4501 C CE1 . PHE   B 1 197 ? 0.412   -23.807 -66.439 1.00 41.45 ? 197 PHE   B CE1 1 
ATOM   4502 C CE2 . PHE   B 1 197 ? -0.590  -25.952 -66.777 1.00 42.76 ? 197 PHE   B CE2 1 
ATOM   4503 C CZ  . PHE   B 1 197 ? 0.514   -25.185 -66.456 1.00 40.26 ? 197 PHE   B CZ  1 
ATOM   4504 N N   . CYS   B 1 198 ? -5.449  -20.863 -67.577 1.00 41.39 ? 198 CYS   B N   1 
ATOM   4505 C CA  . CYS   B 1 198 ? -6.609  -20.358 -68.297 1.00 40.75 ? 198 CYS   B CA  1 
ATOM   4506 C C   . CYS   B 1 198 ? -6.867  -18.876 -68.067 1.00 43.55 ? 198 CYS   B C   1 
ATOM   4507 O O   . CYS   B 1 198 ? -7.785  -18.322 -68.680 1.00 46.20 ? 198 CYS   B O   1 
ATOM   4508 C CB  . CYS   B 1 198 ? -7.857  -21.162 -67.917 1.00 42.66 ? 198 CYS   B CB  1 
ATOM   4509 S SG  . CYS   B 1 198 ? -7.932  -22.805 -68.658 1.00 44.24 ? 198 CYS   B SG  1 
ATOM   4510 N N   . GLY   B 1 199 ? -6.095  -18.222 -67.205 1.00 41.37 ? 199 GLY   B N   1 
ATOM   4511 C CA  . GLY   B 1 199 ? -6.238  -16.790 -66.998 1.00 39.70 ? 199 GLY   B CA  1 
ATOM   4512 C C   . GLY   B 1 199 ? -7.518  -16.366 -66.312 1.00 43.15 ? 199 GLY   B C   1 
ATOM   4513 O O   . GLY   B 1 199 ? -8.147  -15.385 -66.731 1.00 42.16 ? 199 GLY   B O   1 
ATOM   4514 N N   . VAL   B 1 200 ? -7.922  -17.082 -65.266 1.00 42.04 ? 200 VAL   B N   1 
ATOM   4515 C CA  . VAL   B 1 200 ? -9.088  -16.704 -64.476 1.00 40.10 ? 200 VAL   B CA  1 
ATOM   4516 C C   . VAL   B 1 200 ? -8.665  -16.539 -63.023 1.00 42.24 ? 200 VAL   B C   1 
ATOM   4517 O O   . VAL   B 1 200 ? -7.475  -16.612 -62.698 1.00 43.52 ? 200 VAL   B O   1 
ATOM   4518 C CB  . VAL   B 1 200 ? -10.224 -17.736 -64.610 1.00 39.59 ? 200 VAL   B CB  1 
ATOM   4519 C CG1 . VAL   B 1 200 ? -10.796 -17.720 -66.018 1.00 39.94 ? 200 VAL   B CG1 1 
ATOM   4520 C CG2 . VAL   B 1 200 ? -9.723  -19.126 -64.247 1.00 37.31 ? 200 VAL   B CG2 1 
ATOM   4521 N N   . TRP   B 1 201 ? -9.635  -16.317 -62.140 1.00 42.44 ? 201 TRP   B N   1 
ATOM   4522 C CA  . TRP   B 1 201 ? -9.371  -16.105 -60.724 1.00 38.54 ? 201 TRP   B CA  1 
ATOM   4523 C C   . TRP   B 1 201 ? -9.634  -17.387 -59.946 1.00 41.75 ? 201 TRP   B C   1 
ATOM   4524 O O   . TRP   B 1 201 ? -10.642 -18.065 -60.174 1.00 41.81 ? 201 TRP   B O   1 
ATOM   4525 C CB  . TRP   B 1 201 ? -10.237 -14.973 -60.175 1.00 40.41 ? 201 TRP   B CB  1 
ATOM   4526 C CG  . TRP   B 1 201 ? -9.944  -13.622 -60.767 1.00 43.11 ? 201 TRP   B CG  1 
ATOM   4527 C CD1 . TRP   B 1 201 ? -10.209 -13.210 -62.040 1.00 41.83 ? 201 TRP   B CD1 1 
ATOM   4528 C CD2 . TRP   B 1 201 ? -9.347  -12.503 -60.099 1.00 41.14 ? 201 TRP   B CD2 1 
ATOM   4529 N NE1 . TRP   B 1 201 ? -9.811  -11.904 -62.207 1.00 41.53 ? 201 TRP   B NE1 1 
ATOM   4530 C CE2 . TRP   B 1 201 ? -9.276  -11.448 -61.031 1.00 42.89 ? 201 TRP   B CE2 1 
ATOM   4531 C CE3 . TRP   B 1 201 ? -8.864  -12.292 -58.803 1.00 39.27 ? 201 TRP   B CE3 1 
ATOM   4532 C CZ2 . TRP   B 1 201 ? -8.741  -10.200 -60.707 1.00 42.76 ? 201 TRP   B CZ2 1 
ATOM   4533 C CZ3 . TRP   B 1 201 ? -8.335  -11.053 -58.486 1.00 42.43 ? 201 TRP   B CZ3 1 
ATOM   4534 C CH2 . TRP   B 1 201 ? -8.275  -10.025 -59.436 1.00 44.03 ? 201 TRP   B CH2 1 
ATOM   4535 N N   . GLY   B 1 202 ? -8.726  -17.711 -59.031 1.00 42.64 ? 202 GLY   B N   1 
ATOM   4536 C CA  . GLY   B 1 202 ? -8.871  -18.870 -58.174 1.00 42.00 ? 202 GLY   B CA  1 
ATOM   4537 C C   . GLY   B 1 202 ? -8.217  -18.621 -56.832 1.00 39.65 ? 202 GLY   B C   1 
ATOM   4538 O O   . GLY   B 1 202 ? -7.108  -18.079 -56.772 1.00 40.32 ? 202 GLY   B O   1 
ATOM   4539 N N   . LEU   B 1 203 ? -8.885  -19.004 -55.749 1.00 41.63 ? 203 LEU   B N   1 
ATOM   4540 C CA  . LEU   B 1 203 ? -8.398  -18.735 -54.400 1.00 41.07 ? 203 LEU   B CA  1 
ATOM   4541 C C   . LEU   B 1 203 ? -8.126  -20.049 -53.682 1.00 39.17 ? 203 LEU   B C   1 
ATOM   4542 O O   . LEU   B 1 203 ? -9.060  -20.776 -53.327 1.00 38.94 ? 203 LEU   B O   1 
ATOM   4543 C CB  . LEU   B 1 203 ? -9.396  -17.885 -53.613 1.00 37.42 ? 203 LEU   B CB  1 
ATOM   4544 C CG  . LEU   B 1 203 ? -8.952  -17.596 -52.176 1.00 39.51 ? 203 LEU   B CG  1 
ATOM   4545 C CD1 . LEU   B 1 203 ? -7.649  -16.808 -52.171 1.00 39.48 ? 203 LEU   B CD1 1 
ATOM   4546 C CD2 . LEU   B 1 203 ? -10.027 -16.867 -51.382 1.00 38.21 ? 203 LEU   B CD2 1 
ATOM   4547 N N   . LYS   B 1 204 ? -6.846  -20.353 -53.474 1.00 38.47 ? 204 LYS   B N   1 
ATOM   4548 C CA  . LYS   B 1 204 ? -6.443  -21.395 -52.537 1.00 37.86 ? 204 LYS   B CA  1 
ATOM   4549 C C   . LYS   B 1 204 ? -6.623  -20.828 -51.135 1.00 37.31 ? 204 LYS   B C   1 
ATOM   4550 O O   . LYS   B 1 204 ? -5.935  -19.878 -50.753 1.00 36.32 ? 204 LYS   B O   1 
ATOM   4551 C CB  . LYS   B 1 204 ? -5.000  -21.823 -52.794 1.00 37.15 ? 204 LYS   B CB  1 
ATOM   4552 C CG  . LYS   B 1 204 ? -4.516  -22.996 -51.942 1.00 38.86 ? 204 LYS   B CG  1 
ATOM   4553 C CD  . LYS   B 1 204 ? -3.896  -22.535 -50.627 1.00 36.22 ? 204 LYS   B CD  1 
ATOM   4554 C CE  . LYS   B 1 204 ? -3.683  -23.696 -49.670 1.00 39.99 ? 204 LYS   B CE  1 
ATOM   4555 N NZ  . LYS   B 1 204 ? -3.369  -23.214 -48.299 1.00 40.50 ? 204 LYS   B NZ  1 
ATOM   4556 N N   . THR   B 1 205 ? -7.549  -21.395 -50.371 1.00 38.09 ? 205 THR   B N   1 
ATOM   4557 C CA  . THR   B 1 205 ? -7.943  -20.795 -49.107 1.00 36.78 ? 205 THR   B CA  1 
ATOM   4558 C C   . THR   B 1 205 ? -7.069  -21.290 -47.956 1.00 36.99 ? 205 THR   B C   1 
ATOM   4559 O O   . THR   B 1 205 ? -6.258  -22.207 -48.099 1.00 36.25 ? 205 THR   B O   1 
ATOM   4560 C CB  . THR   B 1 205 ? -9.415  -21.087 -48.816 1.00 35.51 ? 205 THR   B CB  1 
ATOM   4561 O OG1 . THR   B 1 205 ? -9.646  -22.502 -48.871 1.00 36.13 ? 205 THR   B OG1 1 
ATOM   4562 C CG2 . THR   B 1 205 ? -10.300 -20.394 -49.836 1.00 36.84 ? 205 THR   B CG2 1 
ATOM   4563 N N   . THR   B 1 206 ? -7.245  -20.655 -46.798 1.00 38.72 ? 206 THR   B N   1 
ATOM   4564 C CA  . THR   B 1 206 ? -6.565  -21.090 -45.585 1.00 37.24 ? 206 THR   B CA  1 
ATOM   4565 C C   . THR   B 1 206 ? -6.981  -22.511 -45.231 1.00 39.64 ? 206 THR   B C   1 
ATOM   4566 O O   . THR   B 1 206 ? -8.153  -22.879 -45.347 1.00 39.09 ? 206 THR   B O   1 
ATOM   4567 C CB  . THR   B 1 206 ? -6.884  -20.141 -44.423 1.00 41.89 ? 206 THR   B CB  1 
ATOM   4568 O OG1 . THR   B 1 206 ? -6.344  -18.843 -44.700 1.00 40.69 ? 206 THR   B OG1 1 
ATOM   4569 C CG2 . THR   B 1 206 ? -6.298  -20.660 -43.112 1.00 40.54 ? 206 THR   B CG2 1 
ATOM   4570 N N   . PHE   B 1 207 ? -6.006  -23.316 -44.815 1.00 38.90 ? 207 PHE   B N   1 
ATOM   4571 C CA  . PHE   B 1 207 ? -6.280  -24.697 -44.444 1.00 41.18 ? 207 PHE   B CA  1 
ATOM   4572 C C   . PHE   B 1 207 ? -7.289  -24.757 -43.304 1.00 43.45 ? 207 PHE   B C   1 
ATOM   4573 O O   . PHE   B 1 207 ? -7.211  -23.990 -42.341 1.00 43.17 ? 207 PHE   B O   1 
ATOM   4574 C CB  . PHE   B 1 207 ? -4.980  -25.400 -44.044 1.00 41.71 ? 207 PHE   B CB  1 
ATOM   4575 C CG  . PHE   B 1 207 ? -5.164  -26.833 -43.629 1.00 44.96 ? 207 PHE   B CG  1 
ATOM   4576 C CD1 . PHE   B 1 207 ? -5.508  -27.802 -44.559 1.00 41.82 ? 207 PHE   B CD1 1 
ATOM   4577 C CD2 . PHE   B 1 207 ? -4.976  -27.214 -42.311 1.00 43.15 ? 207 PHE   B CD2 1 
ATOM   4578 C CE1 . PHE   B 1 207 ? -5.673  -29.123 -44.178 1.00 43.79 ? 207 PHE   B CE1 1 
ATOM   4579 C CE2 . PHE   B 1 207 ? -5.136  -28.533 -41.924 1.00 46.14 ? 207 PHE   B CE2 1 
ATOM   4580 C CZ  . PHE   B 1 207 ? -5.486  -29.488 -42.858 1.00 48.39 ? 207 PHE   B CZ  1 
ATOM   4581 N N   . ASP   B 1 208 ? -8.258  -25.664 -43.438 1.00 44.14 ? 208 ASP   B N   1 
ATOM   4582 C CA  . ASP   B 1 208 ? -9.333  -25.914 -42.477 1.00 41.95 ? 208 ASP   B CA  1 
ATOM   4583 C C   . ASP   B 1 208 ? -10.346 -24.782 -42.392 1.00 41.84 ? 208 ASP   B C   1 
ATOM   4584 O O   . ASP   B 1 208 ? -11.197 -24.791 -41.494 1.00 42.01 ? 208 ASP   B O   1 
ATOM   4585 C CB  . ASP   B 1 208 ? -8.792  -26.206 -41.074 1.00 44.13 ? 208 ASP   B CB  1 
ATOM   4586 C CG  . ASP   B 1 208 ? -8.720  -27.685 -40.777 1.00 51.07 ? 208 ASP   B CG  1 
ATOM   4587 O OD1 . ASP   B 1 208 ? -9.676  -28.406 -41.132 1.00 50.38 ? 208 ASP   B OD1 1 
ATOM   4588 O OD2 . ASP   B 1 208 ? -7.711  -28.126 -40.190 1.00 58.19 ? 208 ASP   B OD2 1 
ATOM   4589 N N   . ALA   B 1 209 ? -10.300 -23.816 -43.308 1.00 42.28 ? 209 ALA   B N   1 
ATOM   4590 C CA  . ALA   B 1 209 ? -11.250 -22.714 -43.264 1.00 39.47 ? 209 ALA   B CA  1 
ATOM   4591 C C   . ALA   B 1 209 ? -12.571 -23.046 -43.942 1.00 41.27 ? 209 ALA   B C   1 
ATOM   4592 O O   . ALA   B 1 209 ? -13.591 -22.430 -43.616 1.00 41.67 ? 209 ALA   B O   1 
ATOM   4593 C CB  . ALA   B 1 209 ? -10.639 -21.466 -43.904 1.00 38.85 ? 209 ALA   B CB  1 
ATOM   4594 N N   . VAL   B 1 210 ? -12.579 -23.992 -44.874 1.00 39.75 ? 210 VAL   B N   1 
ATOM   4595 C CA  . VAL   B 1 210 ? -13.791 -24.410 -45.565 1.00 40.63 ? 210 VAL   B CA  1 
ATOM   4596 C C   . VAL   B 1 210 ? -13.897 -25.925 -45.468 1.00 43.79 ? 210 VAL   B C   1 
ATOM   4597 O O   . VAL   B 1 210 ? -12.899 -26.637 -45.624 1.00 43.06 ? 210 VAL   B O   1 
ATOM   4598 C CB  . VAL   B 1 210 ? -13.802 -23.956 -47.040 1.00 40.38 ? 210 VAL   B CB  1 
ATOM   4599 C CG1 . VAL   B 1 210 ? -15.136 -24.278 -47.686 1.00 40.26 ? 210 VAL   B CG1 1 
ATOM   4600 C CG2 . VAL   B 1 210 ? -13.504 -22.468 -47.142 1.00 36.55 ? 210 VAL   B CG2 1 
ATOM   4601 N N   . SER   B 1 211 ? -15.105 -26.413 -45.201 1.00 42.44 ? 211 SER   B N   1 
ATOM   4602 C CA  . SER   B 1 211 ? -15.315 -27.841 -44.997 1.00 43.95 ? 211 SER   B CA  1 
ATOM   4603 C C   . SER   B 1 211 ? -15.106 -28.607 -46.297 1.00 44.83 ? 211 SER   B C   1 
ATOM   4604 O O   . SER   B 1 211 ? -15.629 -28.227 -47.348 1.00 43.07 ? 211 SER   B O   1 
ATOM   4605 C CB  . SER   B 1 211 ? -16.720 -28.099 -44.454 1.00 42.97 ? 211 SER   B CB  1 
ATOM   4606 O OG  . SER   B 1 211 ? -16.956 -29.485 -44.281 1.00 43.32 ? 211 SER   B OG  1 
ATOM   4607 N N   . LEU   B 1 212 ? -14.343 -29.693 -46.217 1.00 47.22 ? 212 LEU   B N   1 
ATOM   4608 C CA  . LEU   B 1 212 ? -14.144 -30.602 -47.335 1.00 43.96 ? 212 LEU   B CA  1 
ATOM   4609 C C   . LEU   B 1 212 ? -15.229 -31.667 -47.422 1.00 44.12 ? 212 LEU   B C   1 
ATOM   4610 O O   . LEU   B 1 212 ? -15.113 -32.585 -48.238 1.00 43.16 ? 212 LEU   B O   1 
ATOM   4611 C CB  . LEU   B 1 212 ? -12.774 -31.276 -47.231 1.00 47.50 ? 212 LEU   B CB  1 
ATOM   4612 C CG  . LEU   B 1 212 ? -11.693 -30.839 -48.221 1.00 47.22 ? 212 LEU   B CG  1 
ATOM   4613 C CD1 . LEU   B 1 212 ? -11.338 -29.371 -48.040 1.00 46.93 ? 212 LEU   B CD1 1 
ATOM   4614 C CD2 . LEU   B 1 212 ? -10.455 -31.709 -48.078 1.00 50.23 ? 212 LEU   B CD2 1 
ATOM   4615 N N   . GLU   B 1 213 ? -16.272 -31.562 -46.601 1.00 44.68 ? 213 GLU   B N   1 
ATOM   4616 C CA  . GLU   B 1 213 ? -17.317 -32.578 -46.560 1.00 43.70 ? 213 GLU   B CA  1 
ATOM   4617 C C   . GLU   B 1 213 ? -18.006 -32.702 -47.912 1.00 43.49 ? 213 GLU   B C   1 
ATOM   4618 O O   . GLU   B 1 213 ? -18.353 -31.701 -48.546 1.00 44.52 ? 213 GLU   B O   1 
ATOM   4619 C CB  . GLU   B 1 213 ? -18.341 -32.240 -45.475 1.00 42.54 ? 213 GLU   B CB  1 
ATOM   4620 C CG  . GLU   B 1 213 ? -19.504 -33.220 -45.397 1.00 42.67 ? 213 GLU   B CG  1 
ATOM   4621 C CD  . GLU   B 1 213 ? -20.533 -32.813 -44.362 1.00 49.43 ? 213 GLU   B CD  1 
ATOM   4622 O OE1 . GLU   B 1 213 ? -20.260 -31.878 -43.581 1.00 48.40 ? 213 GLU   B OE1 1 
ATOM   4623 O OE2 . GLU   B 1 213 ? -21.618 -33.428 -44.332 1.00 52.18 ? 213 GLU   B OE2 1 
ATOM   4624 N N   . GLY   B 1 214 ? -18.212 -33.939 -48.350 1.00 38.62 ? 214 GLY   B N   1 
ATOM   4625 C CA  . GLY   B 1 214 ? -18.757 -34.207 -49.657 1.00 43.15 ? 214 GLY   B CA  1 
ATOM   4626 C C   . GLY   B 1 214 ? -17.737 -34.297 -50.774 1.00 42.91 ? 214 GLY   B C   1 
ATOM   4627 O O   . GLY   B 1 214 ? -18.035 -34.891 -51.815 1.00 39.34 ? 214 GLY   B O   1 
ATOM   4628 N N   . HIS   B 1 215 ? -16.554 -33.705 -50.603 1.00 44.50 ? 215 HIS   B N   1 
ATOM   4629 C CA  . HIS   B 1 215 ? -15.437 -33.941 -51.512 1.00 42.45 ? 215 HIS   B CA  1 
ATOM   4630 C C   . HIS   B 1 215 ? -14.819 -35.308 -51.224 1.00 43.32 ? 215 HIS   B C   1 
ATOM   4631 O O   . HIS   B 1 215 ? -13.602 -35.431 -51.027 1.00 45.95 ? 215 HIS   B O   1 
ATOM   4632 C CB  . HIS   B 1 215 ? -14.406 -32.810 -51.391 1.00 40.71 ? 215 HIS   B CB  1 
ATOM   4633 C CG  . HIS   B 1 215 ? -13.388 -32.787 -52.488 1.00 42.69 ? 215 HIS   B CG  1 
ATOM   4634 N ND1 . HIS   B 1 215 ? -12.211 -33.499 -52.413 1.00 42.84 ? 215 HIS   B ND1 1 
ATOM   4635 C CD2 . HIS   B 1 215 ? -13.361 -32.134 -53.674 1.00 40.86 ? 215 HIS   B CD2 1 
ATOM   4636 C CE1 . HIS   B 1 215 ? -11.506 -33.292 -53.510 1.00 41.86 ? 215 HIS   B CE1 1 
ATOM   4637 N NE2 . HIS   B 1 215 ? -12.181 -32.468 -54.292 1.00 41.71 ? 215 HIS   B NE2 1 
ATOM   4638 N N   . TYR   B 1 216 ? -15.655 -36.343 -51.232 1.00 42.61 ? 216 TYR   B N   1 
ATOM   4639 C CA  . TYR   B 1 216 ? -15.220 -37.669 -50.838 1.00 42.89 ? 216 TYR   B CA  1 
ATOM   4640 C C   . TYR   B 1 216 ? -14.517 -38.372 -51.987 1.00 41.45 ? 216 TYR   B C   1 
ATOM   4641 O O   . TYR   B 1 216 ? -14.814 -38.139 -53.164 1.00 43.16 ? 216 TYR   B O   1 
ATOM   4642 C CB  . TYR   B 1 216 ? -16.408 -38.517 -50.394 1.00 44.21 ? 216 TYR   B CB  1 
ATOM   4643 C CG  . TYR   B 1 216 ? -17.150 -38.014 -49.174 1.00 43.51 ? 216 TYR   B CG  1 
ATOM   4644 C CD1 . TYR   B 1 216 ? -16.475 -37.672 -48.015 1.00 44.22 ? 216 TYR   B CD1 1 
ATOM   4645 C CD2 . TYR   B 1 216 ? -18.537 -37.895 -49.180 1.00 42.10 ? 216 TYR   B CD2 1 
ATOM   4646 C CE1 . TYR   B 1 216 ? -17.149 -37.218 -46.896 1.00 44.49 ? 216 TYR   B CE1 1 
ATOM   4647 C CE2 . TYR   B 1 216 ? -19.220 -37.440 -48.068 1.00 42.73 ? 216 TYR   B CE2 1 
ATOM   4648 C CZ  . TYR   B 1 216 ? -18.521 -37.102 -46.929 1.00 43.00 ? 216 TYR   B CZ  1 
ATOM   4649 O OH  . TYR   B 1 216 ? -19.189 -36.651 -45.813 1.00 44.17 ? 216 TYR   B OH  1 
ATOM   4650 N N   . PHE   B 1 217 ? -13.575 -39.235 -51.632 1.00 40.45 ? 217 PHE   B N   1 
ATOM   4651 C CA  . PHE   B 1 217 ? -13.131 -40.243 -52.577 1.00 41.49 ? 217 PHE   B CA  1 
ATOM   4652 C C   . PHE   B 1 217 ? -14.318 -41.135 -52.928 1.00 43.41 ? 217 PHE   B C   1 
ATOM   4653 O O   . PHE   B 1 217 ? -15.134 -41.450 -52.052 1.00 41.95 ? 217 PHE   B O   1 
ATOM   4654 C CB  . PHE   B 1 217 ? -11.993 -41.082 -51.989 1.00 41.22 ? 217 PHE   B CB  1 
ATOM   4655 C CG  . PHE   B 1 217 ? -11.313 -41.980 -52.994 1.00 42.70 ? 217 PHE   B CG  1 
ATOM   4656 C CD1 . PHE   B 1 217 ? -11.758 -43.277 -53.211 1.00 41.95 ? 217 PHE   B CD1 1 
ATOM   4657 C CD2 . PHE   B 1 217 ? -10.232 -41.520 -53.730 1.00 39.91 ? 217 PHE   B CD2 1 
ATOM   4658 C CE1 . PHE   B 1 217 ? -11.134 -44.097 -54.142 1.00 43.03 ? 217 PHE   B CE1 1 
ATOM   4659 C CE2 . PHE   B 1 217 ? -9.606  -42.334 -54.660 1.00 42.55 ? 217 PHE   B CE2 1 
ATOM   4660 C CZ  . PHE   B 1 217 ? -10.057 -43.623 -54.865 1.00 45.36 ? 217 PHE   B CZ  1 
ATOM   4661 N N   . PRO   B 1 218 ? -14.462 -41.536 -54.190 1.00 43.17 ? 218 PRO   B N   1 
ATOM   4662 C CA  . PRO   B 1 218 ? -15.657 -42.286 -54.595 1.00 44.31 ? 218 PRO   B CA  1 
ATOM   4663 C C   . PRO   B 1 218 ? -15.900 -43.518 -53.731 1.00 43.95 ? 218 PRO   B C   1 
ATOM   4664 O O   . PRO   B 1 218 ? -14.983 -44.291 -53.442 1.00 44.37 ? 218 PRO   B O   1 
ATOM   4665 C CB  . PRO   B 1 218 ? -15.349 -42.665 -56.046 1.00 42.89 ? 218 PRO   B CB  1 
ATOM   4666 C CG  . PRO   B 1 218 ? -14.456 -41.577 -56.529 1.00 42.13 ? 218 PRO   B CG  1 
ATOM   4667 C CD  . PRO   B 1 218 ? -13.609 -41.192 -55.344 1.00 42.49 ? 218 PRO   B CD  1 
ATOM   4668 N N   . ARG   B 1 219 ? -17.156 -43.677 -53.305 1.00 45.66 ? 219 ARG   B N   1 
ATOM   4669 C CA  . ARG   B 1 219 ? -17.652 -44.814 -52.528 1.00 44.53 ? 219 ARG   B CA  1 
ATOM   4670 C C   . ARG   B 1 219 ? -17.109 -44.852 -51.103 1.00 45.38 ? 219 ARG   B C   1 
ATOM   4671 O O   . ARG   B 1 219 ? -17.182 -45.894 -50.442 1.00 46.84 ? 219 ARG   B O   1 
ATOM   4672 C CB  . ARG   B 1 219 ? -17.365 -46.144 -53.234 1.00 42.63 ? 219 ARG   B CB  1 
ATOM   4673 C CG  . ARG   B 1 219 ? -17.776 -46.152 -54.694 1.00 45.82 ? 219 ARG   B CG  1 
ATOM   4674 C CD  . ARG   B 1 219 ? -17.424 -47.460 -55.382 1.00 45.15 ? 219 ARG   B CD  1 
ATOM   4675 N NE  . ARG   B 1 219 ? -17.599 -47.361 -56.827 1.00 48.91 ? 219 ARG   B NE  1 
ATOM   4676 C CZ  . ARG   B 1 219 ? -18.760 -47.494 -57.453 1.00 48.24 ? 219 ARG   B CZ  1 
ATOM   4677 N NH1 . ARG   B 1 219 ? -19.878 -47.735 -56.791 1.00 48.84 ? 219 ARG   B NH1 1 
ATOM   4678 N NH2 . ARG   B 1 219 ? -18.798 -47.382 -58.778 1.00 47.76 ? 219 ARG   B NH2 1 
ATOM   4679 N N   . THR   B 1 220 ? -16.572 -43.740 -50.609 1.00 45.90 ? 220 THR   B N   1 
ATOM   4680 C CA  . THR   B 1 220 ? -16.145 -43.611 -49.226 1.00 45.60 ? 220 THR   B CA  1 
ATOM   4681 C C   . THR   B 1 220 ? -16.768 -42.362 -48.616 1.00 45.69 ? 220 THR   B C   1 
ATOM   4682 O O   . THR   B 1 220 ? -17.431 -41.570 -49.291 1.00 43.65 ? 220 THR   B O   1 
ATOM   4683 C CB  . THR   B 1 220 ? -14.615 -43.519 -49.110 1.00 44.87 ? 220 THR   B CB  1 
ATOM   4684 O OG1 . THR   B 1 220 ? -14.187 -42.208 -49.505 1.00 42.69 ? 220 THR   B OG1 1 
ATOM   4685 C CG2 . THR   B 1 220 ? -13.934 -44.557 -49.991 1.00 42.78 ? 220 THR   B CG2 1 
ATOM   4686 N N   . ASP   B 1 221 ? -16.551 -42.190 -47.314 1.00 43.93 ? 221 ASP   B N   1 
ATOM   4687 C CA  . ASP   B 1 221 ? -16.780 -40.911 -46.656 1.00 42.64 ? 221 ASP   B CA  1 
ATOM   4688 C C   . ASP   B 1 221 ? -15.462 -40.294 -46.204 1.00 43.91 ? 221 ASP   B C   1 
ATOM   4689 O O   . ASP   B 1 221 ? -15.405 -39.590 -45.193 1.00 46.39 ? 221 ASP   B O   1 
ATOM   4690 C CB  . ASP   B 1 221 ? -17.754 -41.055 -45.486 1.00 47.29 ? 221 ASP   B CB  1 
ATOM   4691 C CG  . ASP   B 1 221 ? -17.332 -42.114 -44.488 1.00 45.03 ? 221 ASP   B CG  1 
ATOM   4692 O OD1 . ASP   B 1 221 ? -16.165 -42.558 -44.518 1.00 44.69 ? 221 ASP   B OD1 1 
ATOM   4693 O OD2 . ASP   B 1 221 ? -18.182 -42.512 -43.665 1.00 45.73 ? 221 ASP   B OD2 1 
ATOM   4694 N N   . SER   B 1 222 ? -14.395 -40.568 -46.951 1.00 42.49 ? 222 SER   B N   1 
ATOM   4695 C CA  . SER   B 1 222 ? -13.069 -40.029 -46.676 1.00 42.69 ? 222 SER   B CA  1 
ATOM   4696 C C   . SER   B 1 222 ? -12.885 -38.756 -47.493 1.00 44.89 ? 222 SER   B C   1 
ATOM   4697 O O   . SER   B 1 222 ? -12.664 -38.816 -48.708 1.00 46.42 ? 222 SER   B O   1 
ATOM   4698 C CB  . SER   B 1 222 ? -11.993 -41.057 -47.015 1.00 41.74 ? 222 SER   B CB  1 
ATOM   4699 O OG  . SER   B 1 222 ? -12.168 -42.248 -46.267 1.00 48.05 ? 222 SER   B OG  1 
ATOM   4700 N N   . ALA   B 1 223 ? -12.986 -37.610 -46.834 1.00 43.84 ? 223 ALA   B N   1 
ATOM   4701 C CA  . ALA   B 1 223 ? -12.738 -36.322 -47.467 1.00 45.83 ? 223 ALA   B CA  1 
ATOM   4702 C C   . ALA   B 1 223 ? -11.588 -35.568 -46.826 1.00 51.33 ? 223 ALA   B C   1 
ATOM   4703 O O   . ALA   B 1 223 ? -10.803 -34.928 -47.534 1.00 50.43 ? 223 ALA   B O   1 
ATOM   4704 C CB  . ALA   B 1 223 ? -14.000 -35.450 -47.428 1.00 44.36 ? 223 ALA   B CB  1 
ATOM   4705 N N   . LYS   B 1 224 ? -11.465 -35.637 -45.501 1.00 55.38 ? 224 LYS   B N   1 
ATOM   4706 C CA  . LYS   B 1 224 ? -10.395 -34.939 -44.806 1.00 55.60 ? 224 LYS   B CA  1 
ATOM   4707 C C   . LYS   B 1 224 ? -9.034  -35.444 -45.266 1.00 57.94 ? 224 LYS   B C   1 
ATOM   4708 O O   . LYS   B 1 224 ? -8.838  -36.640 -45.508 1.00 59.73 ? 224 LYS   B O   1 
ATOM   4709 C CB  . LYS   B 1 224 ? -10.539 -35.119 -43.295 1.00 56.83 ? 224 LYS   B CB  1 
ATOM   4710 C CG  . LYS   B 1 224 ? -10.880 -33.836 -42.555 1.00 58.51 ? 224 LYS   B CG  1 
ATOM   4711 C CD  . LYS   B 1 224 ? -12.076 -33.147 -43.187 1.00 57.05 ? 224 LYS   B CD  1 
ATOM   4712 C CE  . LYS   B 1 224 ? -12.332 -31.801 -42.541 1.00 58.22 ? 224 LYS   B CE  1 
ATOM   4713 N NZ  . LYS   B 1 224 ? -13.374 -31.039 -43.270 1.00 54.46 ? 224 LYS   B NZ  1 
ATOM   4714 N N   . ALA   B 1 225 ? -8.096  -34.508 -45.389 1.00 57.77 ? 225 ALA   B N   1 
ATOM   4715 C CA  . ALA   B 1 225 ? -6.721  -34.804 -45.758 1.00 54.86 ? 225 ALA   B CA  1 
ATOM   4716 C C   . ALA   B 1 225 ? -5.861  -33.579 -45.486 1.00 52.94 ? 225 ALA   B C   1 
ATOM   4717 O O   . ALA   B 1 225 ? -6.248  -32.458 -45.829 1.00 51.94 ? 225 ALA   B O   1 
ATOM   4718 C CB  . ALA   B 1 225 ? -6.624  -35.218 -47.227 1.00 51.33 ? 225 ALA   B CB  1 
ATOM   4719 N N   . ASP   B 1 226 ? -4.708  -33.776 -44.857 1.00 50.29 ? 226 ASP   B N   1 
ATOM   4720 C CA  . ASP   B 1 226 ? -3.799  -32.666 -44.616 1.00 49.47 ? 226 ASP   B CA  1 
ATOM   4721 C C   . ASP   B 1 226 ? -3.409  -32.008 -45.936 1.00 47.72 ? 226 ASP   B C   1 
ATOM   4722 O O   . ASP   B 1 226 ? -3.409  -32.645 -46.993 1.00 48.31 ? 226 ASP   B O   1 
ATOM   4723 C CB  . ASP   B 1 226 ? -2.557  -33.153 -43.868 1.00 49.79 ? 226 ASP   B CB  1 
ATOM   4724 C CG  . ASP   B 1 226 ? -2.877  -33.646 -42.468 1.00 50.32 ? 226 ASP   B CG  1 
ATOM   4725 O OD1 . ASP   B 1 226 ? -3.059  -32.803 -41.563 1.00 53.58 ? 226 ASP   B OD1 1 
ATOM   4726 O OD2 . ASP   B 1 226 ? -2.963  -34.877 -42.276 1.00 51.23 ? 226 ASP   B OD2 1 
ATOM   4727 N N   . LEU   B 1 227 ? -3.110  -30.707 -45.862 1.00 46.74 ? 227 LEU   B N   1 
ATOM   4728 C CA  . LEU   B 1 227 ? -2.641  -29.884 -46.978 1.00 45.29 ? 227 LEU   B CA  1 
ATOM   4729 C C   . LEU   B 1 227 ? -3.760  -29.471 -47.933 1.00 43.59 ? 227 LEU   B C   1 
ATOM   4730 O O   . LEU   B 1 227 ? -3.773  -28.333 -48.410 1.00 41.33 ? 227 LEU   B O   1 
ATOM   4731 C CB  . LEU   B 1 227 ? -1.531  -30.598 -47.759 1.00 42.53 ? 227 LEU   B CB  1 
ATOM   4732 C CG  . LEU   B 1 227 ? -0.311  -31.068 -46.965 1.00 43.46 ? 227 LEU   B CG  1 
ATOM   4733 C CD1 . LEU   B 1 227 ? 0.469   -32.103 -47.756 1.00 44.34 ? 227 LEU   B CD1 1 
ATOM   4734 C CD2 . LEU   B 1 227 ? 0.574   -29.886 -46.605 1.00 41.56 ? 227 LEU   B CD2 1 
ATOM   4735 N N   . SER   B 1 228 ? -4.699  -30.369 -48.221 1.00 41.51 ? 228 SER   B N   1 
ATOM   4736 C CA  . SER   B 1 228 ? -5.708  -30.088 -49.236 1.00 42.12 ? 228 SER   B CA  1 
ATOM   4737 C C   . SER   B 1 228 ? -6.743  -29.087 -48.732 1.00 42.02 ? 228 SER   B C   1 
ATOM   4738 O O   . SER   B 1 228 ? -7.199  -29.161 -47.588 1.00 40.41 ? 228 SER   B O   1 
ATOM   4739 C CB  . SER   B 1 228 ? -6.405  -31.377 -49.668 1.00 41.75 ? 228 SER   B CB  1 
ATOM   4740 O OG  . SER   B 1 228 ? -7.226  -31.884 -48.632 1.00 45.80 ? 228 SER   B OG  1 
ATOM   4741 N N   . VAL   B 1 229 ? -7.114  -28.142 -49.602 1.00 39.00 ? 229 VAL   B N   1 
ATOM   4742 C CA  . VAL   B 1 229 ? -8.138  -27.144 -49.310 1.00 42.14 ? 229 VAL   B CA  1 
ATOM   4743 C C   . VAL   B 1 229 ? -9.059  -27.016 -50.517 1.00 38.88 ? 229 VAL   B C   1 
ATOM   4744 O O   . VAL   B 1 229 ? -8.733  -27.442 -51.625 1.00 41.17 ? 229 VAL   B O   1 
ATOM   4745 C CB  . VAL   B 1 229 ? -7.546  -25.757 -48.963 1.00 40.78 ? 229 VAL   B CB  1 
ATOM   4746 C CG1 . VAL   B 1 229 ? -6.472  -25.872 -47.897 1.00 38.53 ? 229 VAL   B CG1 1 
ATOM   4747 C CG2 . VAL   B 1 229 ? -7.009  -25.080 -50.217 1.00 37.71 ? 229 VAL   B CG2 1 
ATOM   4748 N N   . VAL   B 1 230 ? -10.222 -26.410 -50.286 1.00 41.63 ? 230 VAL   B N   1 
ATOM   4749 C CA  . VAL   B 1 230 ? -11.163 -26.070 -51.347 1.00 40.73 ? 230 VAL   B CA  1 
ATOM   4750 C C   . VAL   B 1 230 ? -11.345 -24.560 -51.358 1.00 38.52 ? 230 VAL   B C   1 
ATOM   4751 O O   . VAL   B 1 230 ? -11.194 -23.884 -50.332 1.00 40.82 ? 230 VAL   B O   1 
ATOM   4752 C CB  . VAL   B 1 230 ? -12.524 -26.780 -51.190 1.00 39.04 ? 230 VAL   B CB  1 
ATOM   4753 C CG1 . VAL   B 1 230 ? -12.372 -28.281 -51.372 1.00 38.32 ? 230 VAL   B CG1 1 
ATOM   4754 C CG2 . VAL   B 1 230 ? -13.136 -26.462 -49.834 1.00 37.33 ? 230 VAL   B CG2 1 
ATOM   4755 N N   . GLY   B 1 231 ? -11.673 -24.030 -52.531 1.00 36.90 ? 231 GLY   B N   1 
ATOM   4756 C CA  . GLY   B 1 231 ? -11.801 -22.605 -52.704 1.00 39.80 ? 231 GLY   B CA  1 
ATOM   4757 C C   . GLY   B 1 231 ? -12.557 -22.240 -53.964 1.00 39.98 ? 231 GLY   B C   1 
ATOM   4758 O O   . GLY   B 1 231 ? -12.747 -23.063 -54.865 1.00 37.48 ? 231 GLY   B O   1 
ATOM   4759 N N   . PRO   B 1 232 ? -13.003 -20.991 -54.053 1.00 39.18 ? 232 PRO   B N   1 
ATOM   4760 C CA  . PRO   B 1 232 ? -13.789 -20.567 -55.212 1.00 40.14 ? 232 PRO   B CA  1 
ATOM   4761 C C   . PRO   B 1 232 ? -12.911 -20.214 -56.404 1.00 41.12 ? 232 PRO   B C   1 
ATOM   4762 O O   . PRO   B 1 232 ? -11.724 -19.904 -56.280 1.00 43.04 ? 232 PRO   B O   1 
ATOM   4763 C CB  . PRO   B 1 232 ? -14.530 -19.332 -54.692 1.00 38.16 ? 232 PRO   B CB  1 
ATOM   4764 C CG  . PRO   B 1 232 ? -13.581 -18.747 -53.700 1.00 38.38 ? 232 PRO   B CG  1 
ATOM   4765 C CD  . PRO   B 1 232 ? -12.876 -19.915 -53.052 1.00 38.68 ? 232 PRO   B CD  1 
ATOM   4766 N N   . MET   B 1 233 ? -13.533 -20.278 -57.579 1.00 38.87 ? 233 MET   B N   1 
ATOM   4767 C CA  . MET   B 1 233 ? -12.914 -19.907 -58.844 1.00 39.97 ? 233 MET   B CA  1 
ATOM   4768 C C   . MET   B 1 233 ? -13.926 -19.107 -59.653 1.00 39.60 ? 233 MET   B C   1 
ATOM   4769 O O   . MET   B 1 233 ? -15.083 -19.522 -59.785 1.00 40.06 ? 233 MET   B O   1 
ATOM   4770 C CB  . MET   B 1 233 ? -12.459 -21.146 -59.628 1.00 40.17 ? 233 MET   B CB  1 
ATOM   4771 C CG  . MET   B 1 233 ? -11.470 -22.039 -58.889 1.00 39.47 ? 233 MET   B CG  1 
ATOM   4772 S SD  . MET   B 1 233 ? -11.071 -23.538 -59.808 1.00 41.18 ? 233 MET   B SD  1 
ATOM   4773 C CE  . MET   B 1 233 ? -10.255 -22.850 -61.250 1.00 41.54 ? 233 MET   B CE  1 
ATOM   4774 N N   . ALA   B 1 234 ? -13.497 -17.967 -60.187 1.00 39.29 ? 234 ALA   B N   1 
ATOM   4775 C CA  . ALA   B 1 234 ? -14.409 -17.043 -60.853 1.00 40.42 ? 234 ALA   B CA  1 
ATOM   4776 C C   . ALA   B 1 234 ? -13.619 -16.193 -61.842 1.00 40.23 ? 234 ALA   B C   1 
ATOM   4777 O O   . ALA   B 1 234 ? -12.435 -16.441 -62.092 1.00 41.16 ? 234 ALA   B O   1 
ATOM   4778 C CB  . ALA   B 1 234 ? -15.145 -16.174 -59.829 1.00 40.20 ? 234 ALA   B CB  1 
ATOM   4779 N N   . ARG   B 1 235 ? -14.284 -15.180 -62.404 1.00 41.78 ? 235 ARG   B N   1 
ATOM   4780 C CA  . ARG   B 1 235 ? -13.647 -14.210 -63.282 1.00 40.88 ? 235 ARG   B CA  1 
ATOM   4781 C C   . ARG   B 1 235 ? -13.470 -12.840 -62.643 1.00 41.28 ? 235 ARG   B C   1 
ATOM   4782 O O   . ARG   B 1 235 ? -12.756 -12.002 -63.207 1.00 40.63 ? 235 ARG   B O   1 
ATOM   4783 C CB  . ARG   B 1 235 ? -14.449 -14.050 -64.582 1.00 39.52 ? 235 ARG   B CB  1 
ATOM   4784 C CG  . ARG   B 1 235 ? -14.363 -15.238 -65.523 1.00 43.71 ? 235 ARG   B CG  1 
ATOM   4785 C CD  . ARG   B 1 235 ? -14.960 -14.903 -66.881 1.00 33.70 ? 235 ARG   B CD  1 
ATOM   4786 N NE  . ARG   B 1 235 ? -16.388 -14.623 -66.799 1.00 36.09 ? 235 ARG   B NE  1 
ATOM   4787 C CZ  . ARG   B 1 235 ? -17.339 -15.537 -66.938 1.00 39.59 ? 235 ARG   B CZ  1 
ATOM   4788 N NH1 . ARG   B 1 235 ? -17.048 -16.808 -67.161 1.00 38.50 ? 235 ARG   B NH1 1 
ATOM   4789 N NH2 . ARG   B 1 235 ? -18.613 -15.166 -66.857 1.00 37.94 ? 235 ARG   B NH2 1 
ATOM   4790 N N   . THR   B 1 236 ? -14.100 -12.585 -61.499 1.00 40.19 ? 236 THR   B N   1 
ATOM   4791 C CA  . THR   B 1 236 ? -13.960 -11.332 -60.775 1.00 39.76 ? 236 THR   B CA  1 
ATOM   4792 C C   . THR   B 1 236 ? -13.605 -11.615 -59.323 1.00 43.00 ? 236 THR   B C   1 
ATOM   4793 O O   . THR   B 1 236 ? -14.050 -12.619 -58.753 1.00 41.12 ? 236 THR   B O   1 
ATOM   4794 C CB  . THR   B 1 236 ? -15.249 -10.494 -60.822 1.00 40.52 ? 236 THR   B CB  1 
ATOM   4795 O OG1 . THR   B 1 236 ? -16.210 -11.043 -59.911 1.00 41.34 ? 236 THR   B OG1 1 
ATOM   4796 C CG2 . THR   B 1 236 ? -15.840 -10.482 -62.225 1.00 42.17 ? 236 THR   B CG2 1 
ATOM   4797 N N   . PRO   B 1 237 ? -12.796 -10.753 -58.702 1.00 43.84 ? 237 PRO   B N   1 
ATOM   4798 C CA  . PRO   B 1 237 ? -12.485 -10.946 -57.276 1.00 39.52 ? 237 PRO   B CA  1 
ATOM   4799 C C   . PRO   B 1 237 ? -13.692 -10.768 -56.371 1.00 39.49 ? 237 PRO   B C   1 
ATOM   4800 O O   . PRO   B 1 237 ? -13.733 -11.350 -55.279 1.00 41.31 ? 237 PRO   B O   1 
ATOM   4801 C CB  . PRO   B 1 237 ? -11.409 -9.885  -57.007 1.00 38.30 ? 237 PRO   B CB  1 
ATOM   4802 C CG  . PRO   B 1 237 ? -11.607 -8.857  -58.075 1.00 41.15 ? 237 PRO   B CG  1 
ATOM   4803 C CD  . PRO   B 1 237 ? -12.062 -9.618  -59.286 1.00 41.82 ? 237 PRO   B CD  1 
ATOM   4804 N N   . ALA   B 1 238 ? -14.679 -9.972  -56.793 1.00 40.89 ? 238 ALA   B N   1 
ATOM   4805 C CA  . ALA   B 1 238 ? -15.902 -9.822  -56.010 1.00 42.35 ? 238 ALA   B CA  1 
ATOM   4806 C C   . ALA   B 1 238 ? -16.680 -11.127 -55.926 1.00 42.78 ? 238 ALA   B C   1 
ATOM   4807 O O   . ALA   B 1 238 ? -17.320 -11.399 -54.904 1.00 42.47 ? 238 ALA   B O   1 
ATOM   4808 C CB  . ALA   B 1 238 ? -16.779 -8.722  -56.606 1.00 40.35 ? 238 ALA   B CB  1 
ATOM   4809 N N   . ASP   B 1 239 ? -16.649 -11.940 -56.985 1.00 40.89 ? 239 ASP   B N   1 
ATOM   4810 C CA  . ASP   B 1 239 ? -17.312 -13.238 -56.933 1.00 39.05 ? 239 ASP   B CA  1 
ATOM   4811 C C   . ASP   B 1 239 ? -16.591 -14.198 -55.999 1.00 41.34 ? 239 ASP   B C   1 
ATOM   4812 O O   . ASP   B 1 239 ? -17.233 -15.050 -55.372 1.00 39.76 ? 239 ASP   B O   1 
ATOM   4813 C CB  . ASP   B 1 239 ? -17.409 -13.835 -58.335 1.00 42.60 ? 239 ASP   B CB  1 
ATOM   4814 C CG  . ASP   B 1 239 ? -18.341 -13.056 -59.229 1.00 43.98 ? 239 ASP   B CG  1 
ATOM   4815 O OD1 . ASP   B 1 239 ? -19.001 -12.124 -58.723 1.00 44.66 ? 239 ASP   B OD1 1 
ATOM   4816 O OD2 . ASP   B 1 239 ? -18.410 -13.369 -60.434 1.00 43.40 ? 239 ASP   B OD2 1 
ATOM   4817 N N   . LEU   B 1 240 ? -15.266 -14.077 -55.894 1.00 42.18 ? 240 LEU   B N   1 
ATOM   4818 C CA  . LEU   B 1 240 ? -14.513 -14.925 -54.977 1.00 40.38 ? 240 LEU   B CA  1 
ATOM   4819 C C   . LEU   B 1 240 ? -14.868 -14.614 -53.528 1.00 39.88 ? 240 LEU   B C   1 
ATOM   4820 O O   . LEU   B 1 240 ? -15.062 -15.523 -52.714 1.00 38.23 ? 240 LEU   B O   1 
ATOM   4821 C CB  . LEU   B 1 240 ? -13.012 -14.746 -55.211 1.00 41.04 ? 240 LEU   B CB  1 
ATOM   4822 C CG  . LEU   B 1 240 ? -12.437 -15.151 -56.569 1.00 40.37 ? 240 LEU   B CG  1 
ATOM   4823 C CD1 . LEU   B 1 240 ? -10.944 -14.860 -56.618 1.00 39.79 ? 240 LEU   B CD1 1 
ATOM   4824 C CD2 . LEU   B 1 240 ? -12.704 -16.620 -56.843 1.00 39.40 ? 240 LEU   B CD2 1 
ATOM   4825 N N   . ALA   B 1 241 ? -14.958 -13.325 -53.190 1.00 41.73 ? 241 ALA   B N   1 
ATOM   4826 C CA  . ALA   B 1 241 ? -15.258 -12.927 -51.818 1.00 39.82 ? 241 ALA   B CA  1 
ATOM   4827 C C   . ALA   B 1 241 ? -16.646 -13.397 -51.401 1.00 40.02 ? 241 ALA   B C   1 
ATOM   4828 O O   . ALA   B 1 241 ? -16.827 -13.935 -50.303 1.00 40.12 ? 241 ALA   B O   1 
ATOM   4829 C CB  . ALA   B 1 241 ? -15.136 -11.408 -51.677 1.00 37.45 ? 241 ALA   B CB  1 
ATOM   4830 N N   . LEU   B 1 242 ? -17.640 -13.206 -52.270 1.00 36.97 ? 242 LEU   B N   1 
ATOM   4831 C CA  . LEU   B 1 242 ? -18.997 -13.642 -51.950 1.00 39.98 ? 242 LEU   B CA  1 
ATOM   4832 C C   . LEU   B 1 242 ? -19.077 -15.158 -51.833 1.00 39.86 ? 242 LEU   B C   1 
ATOM   4833 O O   . LEU   B 1 242 ? -19.702 -15.679 -50.903 1.00 40.97 ? 242 LEU   B O   1 
ATOM   4834 C CB  . LEU   B 1 242 ? -19.984 -13.129 -53.003 1.00 38.90 ? 242 LEU   B CB  1 
ATOM   4835 C CG  . LEU   B 1 242 ? -21.428 -13.634 -52.889 1.00 36.18 ? 242 LEU   B CG  1 
ATOM   4836 C CD1 . LEU   B 1 242 ? -22.021 -13.301 -51.520 1.00 34.84 ? 242 LEU   B CD1 1 
ATOM   4837 C CD2 . LEU   B 1 242 ? -22.294 -13.060 -53.995 1.00 41.23 ? 242 LEU   B CD2 1 
ATOM   4838 N N   . ALA   B 1 243 ? -18.448 -15.885 -52.758 1.00 36.32 ? 243 ALA   B N   1 
ATOM   4839 C CA  . ALA   B 1 243 ? -18.468 -17.342 -52.677 1.00 36.11 ? 243 ALA   B CA  1 
ATOM   4840 C C   . ALA   B 1 243 ? -17.744 -17.835 -51.430 1.00 39.24 ? 243 ALA   B C   1 
ATOM   4841 O O   . ALA   B 1 243 ? -18.116 -18.864 -50.853 1.00 42.11 ? 243 ALA   B O   1 
ATOM   4842 C CB  . ALA   B 1 243 ? -17.852 -17.948 -53.938 1.00 38.91 ? 243 ALA   B CB  1 
ATOM   4843 N N   . LEU   B 1 244 ? -16.711 -17.108 -50.994 1.00 41.34 ? 244 LEU   B N   1 
ATOM   4844 C CA  . LEU   B 1 244 ? -15.998 -17.487 -49.778 1.00 38.39 ? 244 LEU   B CA  1 
ATOM   4845 C C   . LEU   B 1 244 ? -16.872 -17.295 -48.545 1.00 41.25 ? 244 LEU   B C   1 
ATOM   4846 O O   . LEU   B 1 244 ? -16.899 -18.155 -47.655 1.00 44.29 ? 244 LEU   B O   1 
ATOM   4847 C CB  . LEU   B 1 244 ? -14.709 -16.674 -49.653 1.00 37.13 ? 244 LEU   B CB  1 
ATOM   4848 C CG  . LEU   B 1 244 ? -13.821 -16.999 -48.447 1.00 40.55 ? 244 LEU   B CG  1 
ATOM   4849 C CD1 . LEU   B 1 244 ? -13.164 -18.357 -48.618 1.00 40.41 ? 244 LEU   B CD1 1 
ATOM   4850 C CD2 . LEU   B 1 244 ? -12.775 -15.914 -48.211 1.00 42.16 ? 244 LEU   B CD2 1 
ATOM   4851 N N   . ASP   B 1 245 ? -17.592 -16.172 -48.478 1.00 41.63 ? 245 ASP   B N   1 
ATOM   4852 C CA  . ASP   B 1 245 ? -18.482 -15.918 -47.349 1.00 43.26 ? 245 ASP   B CA  1 
ATOM   4853 C C   . ASP   B 1 245 ? -19.611 -16.938 -47.282 1.00 41.58 ? 245 ASP   B C   1 
ATOM   4854 O O   . ASP   B 1 245 ? -20.110 -17.242 -46.192 1.00 41.78 ? 245 ASP   B O   1 
ATOM   4855 C CB  . ASP   B 1 245 ? -19.052 -14.503 -47.442 1.00 40.00 ? 245 ASP   B CB  1 
ATOM   4856 C CG  . ASP   B 1 245 ? -18.009 -13.431 -47.179 1.00 46.80 ? 245 ASP   B CG  1 
ATOM   4857 O OD1 . ASP   B 1 245 ? -17.156 -13.635 -46.294 1.00 45.97 ? 245 ASP   B OD1 1 
ATOM   4858 O OD2 . ASP   B 1 245 ? -18.050 -12.381 -47.853 1.00 49.48 ? 245 ASP   B OD2 1 
ATOM   4859 N N   . ILE   B 1 246 ? -20.017 -17.486 -48.429 1.00 40.77 ? 246 ILE   B N   1 
ATOM   4860 C CA  . ILE   B 1 246 ? -21.126 -18.434 -48.460 1.00 40.40 ? 246 ILE   B CA  1 
ATOM   4861 C C   . ILE   B 1 246 ? -20.695 -19.806 -47.953 1.00 40.81 ? 246 ILE   B C   1 
ATOM   4862 O O   . ILE   B 1 246 ? -21.476 -20.507 -47.297 1.00 41.42 ? 246 ILE   B O   1 
ATOM   4863 C CB  . ILE   B 1 246 ? -21.703 -18.512 -49.888 1.00 38.78 ? 246 ILE   B CB  1 
ATOM   4864 C CG1 . ILE   B 1 246 ? -22.411 -17.205 -50.254 1.00 36.99 ? 246 ILE   B CG1 1 
ATOM   4865 C CG2 . ILE   B 1 246 ? -22.655 -19.696 -50.038 1.00 38.75 ? 246 ILE   B CG2 1 
ATOM   4866 C CD1 . ILE   B 1 246 ? -22.787 -17.104 -51.720 1.00 34.87 ? 246 ILE   B CD1 1 
ATOM   4867 N N   . THR   B 1 247 ? -19.451 -20.203 -48.215 1.00 41.66 ? 247 THR   B N   1 
ATOM   4868 C CA  . THR   B 1 247 ? -19.030 -21.584 -48.031 1.00 40.88 ? 247 THR   B CA  1 
ATOM   4869 C C   . THR   B 1 247 ? -18.129 -21.818 -46.826 1.00 42.79 ? 247 THR   B C   1 
ATOM   4870 O O   . THR   B 1 247 ? -17.974 -22.974 -46.415 1.00 41.55 ? 247 THR   B O   1 
ATOM   4871 C CB  . THR   B 1 247 ? -18.311 -22.084 -49.291 1.00 39.57 ? 247 THR   B CB  1 
ATOM   4872 O OG1 . THR   B 1 247 ? -17.216 -21.211 -49.596 1.00 41.44 ? 247 THR   B OG1 1 
ATOM   4873 C CG2 . THR   B 1 247 ? -19.271 -22.119 -50.470 1.00 40.47 ? 247 THR   B CG2 1 
ATOM   4874 N N   . SER   B 1 248 ? -17.528 -20.779 -46.254 1.00 39.25 ? 248 SER   B N   1 
ATOM   4875 C CA  . SER   B 1 248 ? -16.624 -20.978 -45.129 1.00 42.24 ? 248 SER   B CA  1 
ATOM   4876 C C   . SER   B 1 248 ? -17.368 -21.514 -43.907 1.00 41.83 ? 248 SER   B C   1 
ATOM   4877 O O   . SER   B 1 248 ? -18.555 -21.245 -43.704 1.00 41.85 ? 248 SER   B O   1 
ATOM   4878 C CB  . SER   B 1 248 ? -15.912 -19.671 -44.777 1.00 45.17 ? 248 SER   B CB  1 
ATOM   4879 O OG  . SER   B 1 248 ? -16.842 -18.642 -44.488 1.00 46.92 ? 248 SER   B OG  1 
ATOM   4880 N N   . LYS   B 1 249 ? -16.654 -22.276 -43.076 1.00 38.48 ? 249 LYS   B N   1 
ATOM   4881 C CA  . LYS   B 1 249 ? -17.270 -22.844 -41.849 1.00 41.76 ? 249 LYS   B CA  1 
ATOM   4882 C C   . LYS   B 1 249 ? -17.807 -21.699 -40.986 1.00 40.31 ? 249 LYS   B C   1 
ATOM   4883 O O   . LYS   B 1 249 ? -18.962 -21.791 -40.525 1.00 41.15 ? 249 LYS   B O   1 
ATOM   4884 C CB  . LYS   B 1 249 ? -16.234 -23.649 -41.058 1.00 37.29 ? 249 LYS   B CB  1 
ATOM   4885 C CG  . LYS   B 1 249 ? -15.414 -24.640 -41.863 1.00 42.57 ? 249 LYS   B CG  1 
ATOM   4886 C CD  . LYS   B 1 249 ? -14.415 -25.406 -41.006 1.00 42.14 ? 249 LYS   B CD  1 
ATOM   4887 C CE  . LYS   B 1 249 ? -13.966 -26.677 -41.650 1.00 43.81 ? 249 LYS   B CE  1 
ATOM   4888 N NZ  . LYS   B 1 249 ? -12.669 -27.116 -41.131 1.00 43.99 ? 249 LYS   B NZ  1 
ATOM   4889 N N   . VAL   B 1 250 ? -16.991 -20.670 -40.780 1.00 42.25 ? 250 VAL   B N   1 
ATOM   4890 C CA  . VAL   B 1 250 ? -17.389 -19.501 -39.948 1.00 44.47 ? 250 VAL   B CA  1 
ATOM   4891 C C   . VAL   B 1 250 ? -17.037 -18.253 -40.763 1.00 43.14 ? 250 VAL   B C   1 
ATOM   4892 O O   . VAL   B 1 250 ? -16.092 -18.338 -41.572 1.00 44.58 ? 250 VAL   B O   1 
ATOM   4893 C CB  . VAL   B 1 250 ? -16.631 -19.593 -38.610 1.00 41.07 ? 250 VAL   B CB  1 
ATOM   4894 C CG1 . VAL   B 1 250 ? -16.013 -18.274 -38.161 1.00 43.04 ? 250 VAL   B CG1 1 
ATOM   4895 C CG2 . VAL   B 1 250 ? -17.484 -20.210 -37.512 1.00 37.83 ? 250 VAL   B CG2 1 
ATOM   4896 N N   . PRO   B 1 251 ? -17.752 -17.114 -40.642 1.00 43.24 ? 251 PRO   B N   1 
ATOM   4897 C CA  . PRO   B 1 251 ? -17.398 -15.992 -41.492 1.00 45.69 ? 251 PRO   B CA  1 
ATOM   4898 C C   . PRO   B 1 251 ? -15.985 -15.565 -41.162 1.00 46.13 ? 251 PRO   B C   1 
ATOM   4899 O O   . PRO   B 1 251 ? -15.671 -15.329 -39.982 1.00 48.88 ? 251 PRO   B O   1 
ATOM   4900 C CB  . PRO   B 1 251 ? -18.431 -14.949 -41.064 1.00 45.12 ? 251 PRO   B CB  1 
ATOM   4901 C CG  . PRO   B 1 251 ? -19.577 -15.759 -40.501 1.00 43.37 ? 251 PRO   B CG  1 
ATOM   4902 C CD  . PRO   B 1 251 ? -18.913 -16.924 -39.797 1.00 44.63 ? 251 PRO   B CD  1 
ATOM   4903 N N   . LEU   B 1 252 ? -15.161 -15.410 -42.197 1.00 43.64 ? 252 LEU   B N   1 
ATOM   4904 C CA  . LEU   B 1 252 ? -13.747 -14.992 -42.017 1.00 46.00 ? 252 LEU   B CA  1 
ATOM   4905 C C   . LEU   B 1 252 ? -13.664 -13.471 -41.837 1.00 46.15 ? 252 LEU   B C   1 
ATOM   4906 O O   . LEU   B 1 252 ? -14.543 -12.764 -42.357 1.00 44.45 ? 252 LEU   B O   1 
ATOM   4907 C CB  . LEU   B 1 252 ? -12.916 -15.500 -43.194 1.00 45.57 ? 252 LEU   B CB  1 
ATOM   4908 C CG  . LEU   B 1 252 ? -12.860 -17.023 -43.346 1.00 48.20 ? 252 LEU   B CG  1 
ATOM   4909 C CD1 . LEU   B 1 252 ? -11.996 -17.428 -44.525 1.00 41.97 ? 252 LEU   B CD1 1 
ATOM   4910 C CD2 . LEU   B 1 252 ? -12.368 -17.673 -42.066 1.00 43.43 ? 252 LEU   B CD2 1 
ATOM   4911 N N   . PRO   B 1 253 ? -12.631 -12.936 -41.158 1.00 46.17 ? 253 PRO   B N   1 
ATOM   4912 C CA  . PRO   B 1 253 ? -12.481 -11.492 -41.051 1.00 47.18 ? 253 PRO   B CA  1 
ATOM   4913 C C   . PRO   B 1 253 ? -12.436 -10.791 -42.403 1.00 48.95 ? 253 PRO   B C   1 
ATOM   4914 O O   . PRO   B 1 253 ? -11.674 -11.230 -43.285 1.00 47.65 ? 253 PRO   B O   1 
ATOM   4915 C CB  . PRO   B 1 253 ? -11.158 -11.348 -40.280 1.00 47.99 ? 253 PRO   B CB  1 
ATOM   4916 C CG  . PRO   B 1 253 ? -10.473 -12.685 -40.444 1.00 47.61 ? 253 PRO   B CG  1 
ATOM   4917 C CD  . PRO   B 1 253 ? -11.599 -13.693 -40.480 1.00 44.93 ? 253 PRO   B CD  1 
ATOM   4918 N N   . GLN   B 1 254 ? -13.233 -9.731  -42.574 1.00 50.55 ? 254 GLN   B N   1 
ATOM   4919 C CA  . GLN   B 1 254 ? -13.190 -8.955  -43.800 1.00 45.33 ? 254 GLN   B CA  1 
ATOM   4920 C C   . GLN   B 1 254 ? -11.921 -8.108  -43.857 1.00 46.95 ? 254 GLN   B C   1 
ATOM   4921 O O   . GLN   B 1 254 ? -11.284 -7.820  -42.840 1.00 49.93 ? 254 GLN   B O   1 
ATOM   4922 C CB  . GLN   B 1 254 ? -14.429 -8.065  -43.912 1.00 44.87 ? 254 GLN   B CB  1 
ATOM   4923 C CG  . GLN   B 1 254 ? -15.737 -8.840  -44.029 1.00 47.24 ? 254 GLN   B CG  1 
ATOM   4924 C CD  . GLN   B 1 254 ? -15.904 -9.497  -45.384 1.00 49.65 ? 254 GLN   B CD  1 
ATOM   4925 O OE1 . GLN   B 1 254 ? -15.449 -8.972  -46.398 1.00 50.60 ? 254 GLN   B OE1 1 
ATOM   4926 N NE2 . GLN   B 1 254 ? -16.558 -10.650 -45.408 1.00 50.33 ? 254 GLN   B NE2 1 
ATOM   4927 N N   . SER   B 1 255 ? -11.562 -7.707  -45.074 1.00 50.00 ? 255 SER   B N   1 
ATOM   4928 C CA  . SER   B 1 255 ? -10.354 -6.927  -45.297 1.00 48.60 ? 255 SER   B CA  1 
ATOM   4929 C C   . SER   B 1 255 ? -10.601 -5.455  -44.994 1.00 49.21 ? 255 SER   B C   1 
ATOM   4930 O O   . SER   B 1 255 ? -11.636 -4.893  -45.364 1.00 48.11 ? 255 SER   B O   1 
ATOM   4931 C CB  . SER   B 1 255 ? -9.876  -7.090  -46.740 1.00 46.59 ? 255 SER   B CB  1 
ATOM   4932 O OG  . SER   B 1 255 ? -8.667  -6.384  -46.963 1.00 47.93 ? 255 SER   B OG  1 
ATOM   4933 N N   . ARG   B 1 256 ? -9.642  -4.834  -44.308 1.00 49.21 ? 256 ARG   B N   1 
ATOM   4934 C CA  . ARG   B 1 256 ? -9.659  -3.402  -44.040 1.00 49.96 ? 256 ARG   B CA  1 
ATOM   4935 C C   . ARG   B 1 256 ? -8.715  -2.629  -44.950 1.00 49.22 ? 256 ARG   B C   1 
ATOM   4936 O O   . ARG   B 1 256 ? -8.527  -1.424  -44.755 1.00 51.85 ? 256 ARG   B O   1 
ATOM   4937 C CB  . ARG   B 1 256 ? -9.304  -3.130  -42.578 1.00 52.59 ? 256 ARG   B CB  1 
ATOM   4938 C CG  . ARG   B 1 256 ? -10.351 -3.584  -41.582 1.00 51.54 ? 256 ARG   B CG  1 
ATOM   4939 C CD  . ARG   B 1 256 ? -9.898  -3.269  -40.167 1.00 55.51 ? 256 ARG   B CD  1 
ATOM   4940 N NE  . ARG   B 1 256 ? -9.421  -1.895  -40.059 1.00 61.86 ? 256 ARG   B NE  1 
ATOM   4941 C CZ  . ARG   B 1 256 ? -10.102 -0.901  -39.508 1.00 65.21 ? 256 ARG   B CZ  1 
ATOM   4942 N NH1 . ARG   B 1 256 ? -11.292 -1.097  -38.967 1.00 64.70 ? 256 ARG   B NH1 1 
ATOM   4943 N NH2 . ARG   B 1 256 ? -9.572  0.318   -39.492 1.00 58.80 ? 256 ARG   B NH2 1 
ATOM   4944 N N   . ILE   B 1 257 ? -8.119  -3.295  -45.933 1.00 49.19 ? 257 ILE   B N   1 
ATOM   4945 C CA  . ILE   B 1 257 ? -7.187  -2.651  -46.851 1.00 47.90 ? 257 ILE   B CA  1 
ATOM   4946 C C   . ILE   B 1 257 ? -7.984  -1.888  -47.903 1.00 45.75 ? 257 ILE   B C   1 
ATOM   4947 O O   . ILE   B 1 257 ? -8.705  -2.487  -48.708 1.00 48.37 ? 257 ILE   B O   1 
ATOM   4948 C CB  . ILE   B 1 257 ? -6.253  -3.682  -47.500 1.00 48.70 ? 257 ILE   B CB  1 
ATOM   4949 C CG1 . ILE   B 1 257 ? -5.473  -4.448  -46.429 1.00 46.72 ? 257 ILE   B CG1 1 
ATOM   4950 C CG2 . ILE   B 1 257 ? -5.296  -3.005  -48.465 1.00 46.03 ? 257 ILE   B CG2 1 
ATOM   4951 C CD1 . ILE   B 1 257 ? -4.589  -5.548  -46.986 1.00 45.51 ? 257 ILE   B CD1 1 
ATOM   4952 N N   . ALA   B 1 258 ? -7.852  -0.559  -47.899 1.00 46.27 ? 258 ALA   B N   1 
ATOM   4953 C CA  . ALA   B 1 258 ? -8.579  0.297   -48.827 1.00 46.84 ? 258 ALA   B CA  1 
ATOM   4954 C C   . ALA   B 1 258 ? -7.799  0.624   -50.094 1.00 44.25 ? 258 ALA   B C   1 
ATOM   4955 O O   . ALA   B 1 258 ? -8.420  0.942   -51.115 1.00 46.67 ? 258 ALA   B O   1 
ATOM   4956 C CB  . ALA   B 1 258 ? -8.980  1.605   -48.134 1.00 44.85 ? 258 ALA   B CB  1 
ATOM   4957 N N   . ASN   B 1 259 ? -6.469  0.566   -50.050 1.00 44.62 ? 259 ASN   B N   1 
ATOM   4958 C CA  . ASN   B 1 259 ? -5.634  0.792   -51.226 1.00 46.53 ? 259 ASN   B CA  1 
ATOM   4959 C C   . ASN   B 1 259 ? -4.267  0.165   -50.972 1.00 45.01 ? 259 ASN   B C   1 
ATOM   4960 O O   . ASN   B 1 259 ? -4.034  -0.467  -49.937 1.00 47.89 ? 259 ASN   B O   1 
ATOM   4961 C CB  . ASN   B 1 259 ? -5.529  2.285   -51.561 1.00 46.85 ? 259 ASN   B CB  1 
ATOM   4962 C CG  . ASN   B 1 259 ? -5.016  3.110   -50.398 1.00 52.65 ? 259 ASN   B CG  1 
ATOM   4963 O OD1 . ASN   B 1 259 ? -3.839  3.050   -50.054 1.00 55.43 ? 259 ASN   B OD1 1 
ATOM   4964 N ND2 . ASN   B 1 259 ? -5.894  3.896   -49.798 1.00 50.89 ? 259 ASN   B ND2 1 
ATOM   4965 N N   . LEU   B 1 260 ? -3.356  0.353   -51.928 1.00 47.01 ? 260 LEU   B N   1 
ATOM   4966 C CA  . LEU   B 1 260 ? -2.037  -0.264  -51.883 1.00 45.32 ? 260 LEU   B CA  1 
ATOM   4967 C C   . LEU   B 1 260 ? -0.986  0.593   -51.190 1.00 47.21 ? 260 LEU   B C   1 
ATOM   4968 O O   . LEU   B 1 260 ? 0.132   0.114   -50.975 1.00 47.83 ? 260 LEU   B O   1 
ATOM   4969 C CB  . LEU   B 1 260 ? -1.560  -0.588  -53.302 1.00 44.39 ? 260 LEU   B CB  1 
ATOM   4970 C CG  . LEU   B 1 260 ? -2.309  -1.705  -54.031 1.00 44.97 ? 260 LEU   B CG  1 
ATOM   4971 C CD1 . LEU   B 1 260 ? -2.201  -1.532  -55.535 1.00 47.63 ? 260 LEU   B CD1 1 
ATOM   4972 C CD2 . LEU   B 1 260 ? -1.774  -3.066  -53.610 1.00 42.81 ? 260 LEU   B CD2 1 
ATOM   4973 N N   . SER   B 1 261 ? -1.308  1.833   -50.832 1.00 46.83 ? 261 SER   B N   1 
ATOM   4974 C CA  . SER   B 1 261 ? -0.329  2.717   -50.207 1.00 48.39 ? 261 SER   B CA  1 
ATOM   4975 C C   . SER   B 1 261 ? 0.081   2.173   -48.843 1.00 48.86 ? 261 SER   B C   1 
ATOM   4976 O O   . SER   B 1 261 ? -0.765  1.977   -47.964 1.00 48.14 ? 261 SER   B O   1 
ATOM   4977 C CB  . SER   B 1 261 ? -0.897  4.126   -50.072 1.00 48.25 ? 261 SER   B CB  1 
ATOM   4978 O OG  . SER   B 1 261 ? -0.031  4.953   -49.315 1.00 51.67 ? 261 SER   B OG  1 
ATOM   4979 N N   . GLY   B 1 262 ? 1.380   1.934   -48.668 1.00 49.77 ? 262 GLY   B N   1 
ATOM   4980 C CA  . GLY   B 1 262 ? 1.910   1.413   -47.428 1.00 47.35 ? 262 GLY   B CA  1 
ATOM   4981 C C   . GLY   B 1 262 ? 1.999   -0.096  -47.356 1.00 49.70 ? 262 GLY   B C   1 
ATOM   4982 O O   . GLY   B 1 262 ? 2.537   -0.622  -46.373 1.00 53.70 ? 262 GLY   B O   1 
ATOM   4983 N N   . LEU   B 1 263 ? 1.493   -0.807  -48.361 1.00 49.06 ? 263 LEU   B N   1 
ATOM   4984 C CA  . LEU   B 1 263 ? 1.524   -2.263  -48.340 1.00 49.00 ? 263 LEU   B CA  1 
ATOM   4985 C C   . LEU   B 1 263 ? 2.961   -2.769  -48.406 1.00 50.89 ? 263 LEU   B C   1 
ATOM   4986 O O   . LEU   B 1 263 ? 3.792   -2.242  -49.153 1.00 50.90 ? 263 LEU   B O   1 
ATOM   4987 C CB  . LEU   B 1 263 ? 0.707   -2.826  -49.505 1.00 48.61 ? 263 LEU   B CB  1 
ATOM   4988 C CG  . LEU   B 1 263 ? 0.151   -4.245  -49.350 1.00 50.38 ? 263 LEU   B CG  1 
ATOM   4989 C CD1 . LEU   B 1 263 ? -1.012  -4.260  -48.367 1.00 47.54 ? 263 LEU   B CD1 1 
ATOM   4990 C CD2 . LEU   B 1 263 ? -0.264  -4.826  -50.693 1.00 50.79 ? 263 LEU   B CD2 1 
ATOM   4991 N N   . ARG   B 1 264 ? 3.247   -3.805  -47.621 1.00 49.25 ? 264 ARG   B N   1 
ATOM   4992 C CA  . ARG   B 1 264 ? 4.578   -4.394  -47.539 1.00 50.31 ? 264 ARG   B CA  1 
ATOM   4993 C C   . ARG   B 1 264 ? 4.587   -5.678  -48.363 1.00 47.16 ? 264 ARG   B C   1 
ATOM   4994 O O   . ARG   B 1 264 ? 4.043   -6.702  -47.938 1.00 43.01 ? 264 ARG   B O   1 
ATOM   4995 C CB  . ARG   B 1 264 ? 4.948   -4.660  -46.083 1.00 48.50 ? 264 ARG   B CB  1 
ATOM   4996 C CG  . ARG   B 1 264 ? 4.814   -3.443  -45.187 1.00 49.61 ? 264 ARG   B CG  1 
ATOM   4997 C CD  . ARG   B 1 264 ? 4.939   -3.846  -43.733 1.00 54.36 ? 264 ARG   B CD  1 
ATOM   4998 N NE  . ARG   B 1 264 ? 3.863   -4.746  -43.335 1.00 52.39 ? 264 ARG   B NE  1 
ATOM   4999 C CZ  . ARG   B 1 264 ? 3.796   -5.365  -42.166 1.00 53.45 ? 264 ARG   B CZ  1 
ATOM   5000 N NH1 . ARG   B 1 264 ? 4.742   -5.221  -41.255 1.00 53.79 ? 264 ARG   B NH1 1 
ATOM   5001 N NH2 . ARG   B 1 264 ? 2.755   -6.151  -41.908 1.00 53.54 ? 264 ARG   B NH2 1 
ATOM   5002 N N   . ILE   B 1 265 ? 5.212   -5.622  -49.535 1.00 46.08 ? 265 ILE   B N   1 
ATOM   5003 C CA  . ILE   B 1 265 ? 5.185   -6.710  -50.505 1.00 46.87 ? 265 ILE   B CA  1 
ATOM   5004 C C   . ILE   B 1 265 ? 6.560   -7.360  -50.557 1.00 45.24 ? 265 ILE   B C   1 
ATOM   5005 O O   . ILE   B 1 265 ? 7.580   -6.665  -50.644 1.00 43.71 ? 265 ILE   B O   1 
ATOM   5006 C CB  . ILE   B 1 265 ? 4.764   -6.207  -51.897 1.00 49.19 ? 265 ILE   B CB  1 
ATOM   5007 C CG1 . ILE   B 1 265 ? 3.332   -5.670  -51.867 1.00 49.98 ? 265 ILE   B CG1 1 
ATOM   5008 C CG2 . ILE   B 1 265 ? 4.912   -7.311  -52.936 1.00 46.09 ? 265 ILE   B CG2 1 
ATOM   5009 C CD1 . ILE   B 1 265 ? 2.864   -5.120  -53.192 1.00 47.82 ? 265 ILE   B CD1 1 
ATOM   5010 N N   . LEU   B 1 266 ? 6.584   -8.691  -50.509 1.00 44.58 ? 266 LEU   B N   1 
ATOM   5011 C CA  . LEU   B 1 266 ? 7.803   -9.473  -50.686 1.00 44.30 ? 266 LEU   B CA  1 
ATOM   5012 C C   . LEU   B 1 266 ? 7.770   -10.096 -52.078 1.00 45.56 ? 266 LEU   B C   1 
ATOM   5013 O O   . LEU   B 1 266 ? 6.997   -11.026 -52.331 1.00 44.54 ? 266 LEU   B O   1 
ATOM   5014 C CB  . LEU   B 1 266 ? 7.934   -10.544 -49.606 1.00 42.45 ? 266 LEU   B CB  1 
ATOM   5015 C CG  . LEU   B 1 266 ? 9.194   -11.409 -49.701 1.00 46.92 ? 266 LEU   B CG  1 
ATOM   5016 C CD1 . LEU   B 1 266 ? 10.446  -10.541 -49.691 1.00 46.88 ? 266 LEU   B CD1 1 
ATOM   5017 C CD2 . LEU   B 1 266 ? 9.244   -12.441 -48.584 1.00 49.46 ? 266 LEU   B CD2 1 
ATOM   5018 N N   . LEU   B 1 267 ? 8.618   -9.588  -52.970 1.00 46.56 ? 267 LEU   B N   1 
ATOM   5019 C CA  . LEU   B 1 267 ? 8.637   -10.002 -54.371 1.00 48.34 ? 267 LEU   B CA  1 
ATOM   5020 C C   . LEU   B 1 267 ? 9.650   -11.128 -54.553 1.00 46.41 ? 267 LEU   B C   1 
ATOM   5021 O O   . LEU   B 1 267 ? 10.855  -10.924 -54.375 1.00 49.49 ? 267 LEU   B O   1 
ATOM   5022 C CB  . LEU   B 1 267 ? 8.967   -8.809  -55.264 1.00 45.98 ? 267 LEU   B CB  1 
ATOM   5023 C CG  . LEU   B 1 267 ? 9.451   -9.054  -56.695 1.00 49.18 ? 267 LEU   B CG  1 
ATOM   5024 C CD1 . LEU   B 1 267 ? 8.375   -9.712  -57.537 1.00 51.73 ? 267 LEU   B CD1 1 
ATOM   5025 C CD2 . LEU   B 1 267 ? 9.910   -7.749  -57.327 1.00 50.81 ? 267 LEU   B CD2 1 
ATOM   5026 N N   . LEU   B 1 268 ? 9.161   -12.313 -54.914 1.00 43.87 ? 268 LEU   B N   1 
ATOM   5027 C CA  . LEU   B 1 268 ? 10.002  -13.478 -55.153 1.00 46.42 ? 268 LEU   B CA  1 
ATOM   5028 C C   . LEU   B 1 268 ? 9.849   -13.914 -56.602 1.00 49.21 ? 268 LEU   B C   1 
ATOM   5029 O O   . LEU   B 1 268 ? 8.732   -14.178 -57.060 1.00 49.89 ? 268 LEU   B O   1 
ATOM   5030 C CB  . LEU   B 1 268 ? 9.635   -14.633 -54.215 1.00 46.69 ? 268 LEU   B CB  1 
ATOM   5031 C CG  . LEU   B 1 268 ? 9.739   -14.394 -52.707 1.00 46.22 ? 268 LEU   B CG  1 
ATOM   5032 C CD1 . LEU   B 1 268 ? 9.371   -15.659 -51.941 1.00 45.05 ? 268 LEU   B CD1 1 
ATOM   5033 C CD2 . LEU   B 1 268 ? 11.131  -13.917 -52.325 1.00 47.28 ? 268 LEU   B CD2 1 
ATOM   5034 N N   . THR   B 1 269 ? 10.969  -13.980 -57.325 1.00 49.69 ? 269 THR   B N   1 
ATOM   5035 C CA  . THR   B 1 269 ? 10.976  -14.461 -58.701 1.00 48.90 ? 269 THR   B CA  1 
ATOM   5036 C C   . THR   B 1 269 ? 11.969  -15.598 -58.904 1.00 48.80 ? 269 THR   B C   1 
ATOM   5037 O O   . THR   B 1 269 ? 12.157  -16.046 -60.042 1.00 52.22 ? 269 THR   B O   1 
ATOM   5038 C CB  . THR   B 1 269 ? 11.285  -13.321 -59.682 1.00 50.66 ? 269 THR   B CB  1 
ATOM   5039 O OG1 . THR   B 1 269 ? 12.557  -12.743 -59.366 1.00 50.90 ? 269 THR   B OG1 1 
ATOM   5040 C CG2 . THR   B 1 269 ? 10.211  -12.247 -59.611 1.00 50.98 ? 269 THR   B CG2 1 
ATOM   5041 N N   . ALA   B 1 270 ? 12.609  -16.071 -57.839 1.00 51.25 ? 270 ALA   B N   1 
ATOM   5042 C CA  . ALA   B 1 270 ? 13.520  -17.200 -57.909 1.00 50.82 ? 270 ALA   B CA  1 
ATOM   5043 C C   . ALA   B 1 270 ? 13.173  -18.193 -56.810 1.00 51.11 ? 270 ALA   B C   1 
ATOM   5044 O O   . ALA   B 1 270 ? 12.571  -17.843 -55.792 1.00 49.42 ? 270 ALA   B O   1 
ATOM   5045 C CB  . ALA   B 1 270 ? 14.983  -16.762 -57.776 1.00 49.76 ? 270 ALA   B CB  1 
ATOM   5046 N N   . HIS   B 1 271 ? 13.560  -19.447 -57.037 1.00 50.13 ? 271 HIS   B N   1 
ATOM   5047 C CA  . HIS   B 1 271 ? 13.368  -20.517 -56.076 1.00 51.87 ? 271 HIS   B CA  1 
ATOM   5048 C C   . HIS   B 1 271 ? 14.613  -21.392 -56.104 1.00 52.94 ? 271 HIS   B C   1 
ATOM   5049 O O   . HIS   B 1 271 ? 15.135  -21.690 -57.189 1.00 54.16 ? 271 HIS   B O   1 
ATOM   5050 C CB  . HIS   B 1 271 ? 12.127  -21.361 -56.391 1.00 54.07 ? 271 HIS   B CB  1 
ATOM   5051 C CG  . HIS   B 1 271 ? 11.701  -22.254 -55.267 1.00 53.37 ? 271 HIS   B CG  1 
ATOM   5052 N ND1 . HIS   B 1 271 ? 12.319  -23.455 -54.993 1.00 52.29 ? 271 HIS   B ND1 1 
ATOM   5053 C CD2 . HIS   B 1 271 ? 10.718  -22.119 -54.346 1.00 50.02 ? 271 HIS   B CD2 1 
ATOM   5054 C CE1 . HIS   B 1 271 ? 11.736  -24.021 -53.952 1.00 51.78 ? 271 HIS   B CE1 1 
ATOM   5055 N NE2 . HIS   B 1 271 ? 10.760  -23.231 -53.541 1.00 50.06 ? 271 HIS   B NE2 1 
ATOM   5056 N N   . PRO   B 1 272 ? 15.114  -21.812 -54.940 1.00 52.39 ? 272 PRO   B N   1 
ATOM   5057 C CA  . PRO   B 1 272 ? 16.356  -22.602 -54.918 1.00 52.96 ? 272 PRO   B CA  1 
ATOM   5058 C C   . PRO   B 1 272 ? 16.241  -23.960 -55.595 1.00 54.47 ? 272 PRO   B C   1 
ATOM   5059 O O   . PRO   B 1 272 ? 17.277  -24.594 -55.835 1.00 56.55 ? 272 PRO   B O   1 
ATOM   5060 C CB  . PRO   B 1 272 ? 16.652  -22.750 -53.420 1.00 53.06 ? 272 PRO   B CB  1 
ATOM   5061 C CG  . PRO   B 1 272 ? 15.325  -22.553 -52.746 1.00 49.42 ? 272 PRO   B CG  1 
ATOM   5062 C CD  . PRO   B 1 272 ? 14.603  -21.543 -53.584 1.00 50.80 ? 272 PRO   B CD  1 
ATOM   5063 N N   . GLU   B 1 273 ? 15.031  -24.425 -55.920 1.00 54.86 ? 273 GLU   B N   1 
ATOM   5064 C CA  . GLU   B 1 273 ? 14.855  -25.760 -56.472 1.00 53.61 ? 273 GLU   B CA  1 
ATOM   5065 C C   . GLU   B 1 273 ? 14.064  -25.807 -57.775 1.00 55.17 ? 273 GLU   B C   1 
ATOM   5066 O O   . GLU   B 1 273 ? 13.781  -26.907 -58.262 1.00 57.09 ? 273 GLU   B O   1 
ATOM   5067 C CB  . GLU   B 1 273 ? 14.174  -26.676 -55.441 1.00 56.38 ? 273 GLU   B CB  1 
ATOM   5068 C CG  . GLU   B 1 273 ? 14.911  -26.779 -54.108 1.00 54.30 ? 273 GLU   B CG  1 
ATOM   5069 C CD  . GLU   B 1 273 ? 16.278  -27.430 -54.234 1.00 57.60 ? 273 GLU   B CD  1 
ATOM   5070 O OE1 . GLU   B 1 273 ? 16.508  -28.156 -55.224 1.00 58.64 ? 273 GLU   B OE1 1 
ATOM   5071 O OE2 . GLU   B 1 273 ? 17.124  -27.220 -53.340 1.00 56.36 ? 273 GLU   B OE2 1 
ATOM   5072 N N   . THR   B 1 274 ? 13.700  -24.667 -58.350 1.00 53.91 ? 274 THR   B N   1 
ATOM   5073 C CA  . THR   B 1 274 ? 13.030  -24.640 -59.648 1.00 53.47 ? 274 THR   B CA  1 
ATOM   5074 C C   . THR   B 1 274 ? 13.364  -23.313 -60.326 1.00 51.82 ? 274 THR   B C   1 
ATOM   5075 O O   . THR   B 1 274 ? 14.305  -22.619 -59.924 1.00 53.06 ? 274 THR   B O   1 
ATOM   5076 C CB  . THR   B 1 274 ? 11.517  -24.878 -59.491 1.00 51.82 ? 274 THR   B CB  1 
ATOM   5077 O OG1 . THR   B 1 274 ? 10.878  -24.766 -60.769 1.00 54.01 ? 274 THR   B OG1 1 
ATOM   5078 C CG2 . THR   B 1 274 ? 10.907  -23.877 -58.532 1.00 50.33 ? 274 THR   B CG2 1 
ATOM   5079 N N   . VAL   B 1 275 ? 12.594  -22.953 -61.354 1.00 50.20 ? 275 VAL   B N   1 
ATOM   5080 C CA  . VAL   B 1 275 ? 12.926  -21.812 -62.200 1.00 51.11 ? 275 VAL   B CA  1 
ATOM   5081 C C   . VAL   B 1 275 ? 11.670  -21.375 -62.943 1.00 52.46 ? 275 VAL   B C   1 
ATOM   5082 O O   . VAL   B 1 275 ? 10.768  -22.179 -63.196 1.00 51.39 ? 275 VAL   B O   1 
ATOM   5083 C CB  . VAL   B 1 275 ? 14.080  -22.174 -63.172 1.00 53.38 ? 275 VAL   B CB  1 
ATOM   5084 C CG1 . VAL   B 1 275 ? 13.687  -23.351 -64.050 1.00 52.41 ? 275 VAL   B CG1 1 
ATOM   5085 C CG2 . VAL   B 1 275 ? 14.501  -20.976 -64.012 1.00 50.54 ? 275 VAL   B CG2 1 
ATOM   5086 N N   . ALA   B 1 276 ? 11.608  -20.087 -63.281 1.00 52.62 ? 276 ALA   B N   1 
ATOM   5087 C CA  . ALA   B 1 276 ? 10.533  -19.516 -64.079 1.00 50.97 ? 276 ALA   B CA  1 
ATOM   5088 C C   . ALA   B 1 276 ? 11.118  -18.856 -65.321 1.00 54.86 ? 276 ALA   B C   1 
ATOM   5089 O O   . ALA   B 1 276 ? 12.249  -18.362 -65.302 1.00 55.39 ? 276 ALA   B O   1 
ATOM   5090 C CB  . ALA   B 1 276 ? 9.721   -18.491 -63.274 1.00 49.88 ? 276 ALA   B CB  1 
ATOM   5091 N N   . ASP   B 1 277 ? 10.340  -18.842 -66.402 1.00 52.92 ? 277 ASP   B N   1 
ATOM   5092 C CA  . ASP   B 1 277 ? 10.841  -18.303 -67.658 1.00 55.69 ? 277 ASP   B CA  1 
ATOM   5093 C C   . ASP   B 1 277 ? 10.790  -16.775 -67.648 1.00 54.53 ? 277 ASP   B C   1 
ATOM   5094 O O   . ASP   B 1 277 ? 10.350  -16.142 -66.684 1.00 54.57 ? 277 ASP   B O   1 
ATOM   5095 C CB  . ASP   B 1 277 ? 10.072  -18.882 -68.847 1.00 57.34 ? 277 ASP   B CB  1 
ATOM   5096 C CG  . ASP   B 1 277 ? 8.575   -18.634 -68.771 1.00 56.37 ? 277 ASP   B CG  1 
ATOM   5097 O OD1 . ASP   B 1 277 ? 8.153   -17.497 -68.482 1.00 55.85 ? 277 ASP   B OD1 1 
ATOM   5098 O OD2 . ASP   B 1 277 ? 7.810   -19.580 -69.042 1.00 54.91 ? 277 ASP   B OD2 1 
ATOM   5099 N N   . SER   B 1 278 ? 11.235  -16.179 -68.758 1.00 54.56 ? 278 SER   B N   1 
ATOM   5100 C CA  . SER   B 1 278 ? 11.415  -14.731 -68.823 1.00 54.06 ? 278 SER   B CA  1 
ATOM   5101 C C   . SER   B 1 278 ? 10.091  -13.991 -68.684 1.00 52.61 ? 278 SER   B C   1 
ATOM   5102 O O   . SER   B 1 278 ? 9.956   -13.093 -67.845 1.00 53.79 ? 278 SER   B O   1 
ATOM   5103 C CB  . SER   B 1 278 ? 12.102  -14.352 -70.135 1.00 53.68 ? 278 SER   B CB  1 
ATOM   5104 O OG  . SER   B 1 278 ? 12.003  -12.960 -70.374 1.00 56.00 ? 278 SER   B OG  1 
ATOM   5105 N N   . ALA   B 1 279 ? 9.104   -14.346 -69.510 1.00 49.85 ? 279 ALA   B N   1 
ATOM   5106 C CA  . ALA   B 1 279 ? 7.834   -13.628 -69.502 1.00 51.65 ? 279 ALA   B CA  1 
ATOM   5107 C C   . ALA   B 1 279 ? 7.150   -13.702 -68.144 1.00 52.61 ? 279 ALA   B C   1 
ATOM   5108 O O   . ALA   B 1 279 ? 6.491   -12.741 -67.730 1.00 51.48 ? 279 ALA   B O   1 
ATOM   5109 C CB  . ALA   B 1 279 ? 6.915   -14.176 -70.594 1.00 50.55 ? 279 ALA   B CB  1 
ATOM   5110 N N   . THR   B 1 280 ? 7.294   -14.824 -67.437 1.00 51.14 ? 280 THR   B N   1 
ATOM   5111 C CA  . THR   B 1 280 ? 6.724   -14.929 -66.099 1.00 52.07 ? 280 THR   B CA  1 
ATOM   5112 C C   . THR   B 1 280 ? 7.460   -14.030 -65.112 1.00 52.32 ? 280 THR   B C   1 
ATOM   5113 O O   . THR   B 1 280 ? 6.828   -13.363 -64.284 1.00 46.93 ? 280 THR   B O   1 
ATOM   5114 C CB  . THR   B 1 280 ? 6.757   -16.384 -65.625 1.00 52.45 ? 280 THR   B CB  1 
ATOM   5115 O OG1 . THR   B 1 280 ? 5.923   -17.191 -66.468 1.00 49.76 ? 280 THR   B OG1 1 
ATOM   5116 C CG2 . THR   B 1 280 ? 6.269   -16.490 -64.192 1.00 45.78 ? 280 THR   B CG2 1 
ATOM   5117 N N   . ILE   B 1 281 ? 8.793   -13.991 -65.191 1.00 52.03 ? 281 ILE   B N   1 
ATOM   5118 C CA  . ILE   B 1 281 ? 9.572   -13.196 -64.244 1.00 49.86 ? 281 ILE   B CA  1 
ATOM   5119 C C   . ILE   B 1 281 ? 9.238   -11.715 -64.391 1.00 51.10 ? 281 ILE   B C   1 
ATOM   5120 O O   . ILE   B 1 281 ? 9.008   -11.011 -63.401 1.00 53.64 ? 281 ILE   B O   1 
ATOM   5121 C CB  . ILE   B 1 281 ? 11.078  -13.461 -64.431 1.00 49.16 ? 281 ILE   B CB  1 
ATOM   5122 C CG1 . ILE   B 1 281 ? 11.448  -14.862 -63.939 1.00 50.19 ? 281 ILE   B CG1 1 
ATOM   5123 C CG2 . ILE   B 1 281 ? 11.898  -12.417 -63.697 1.00 49.64 ? 281 ILE   B CG2 1 
ATOM   5124 C CD1 . ILE   B 1 281 ? 12.931  -15.179 -64.058 1.00 49.72 ? 281 ILE   B CD1 1 
ATOM   5125 N N   . SER   B 1 282 ? 9.185   -11.226 -65.632 1.00 53.59 ? 282 SER   B N   1 
ATOM   5126 C CA  . SER   B 1 282 ? 8.888   -9.820  -65.883 1.00 52.03 ? 282 SER   B CA  1 
ATOM   5127 C C   . SER   B 1 282 ? 7.420   -9.477  -65.662 1.00 52.66 ? 282 SER   B C   1 
ATOM   5128 O O   . SER   B 1 282 ? 7.102   -8.306  -65.428 1.00 56.51 ? 282 SER   B O   1 
ATOM   5129 C CB  . SER   B 1 282 ? 9.294   -9.443  -67.310 1.00 54.28 ? 282 SER   B CB  1 
ATOM   5130 O OG  . SER   B 1 282 ? 9.158   -8.050  -67.528 1.00 63.46 ? 282 SER   B OG  1 
ATOM   5131 N N   . ALA   B 1 283 ? 6.521   -10.463 -65.738 1.00 50.31 ? 283 ALA   B N   1 
ATOM   5132 C CA  . ALA   B 1 283 ? 5.119   -10.200 -65.432 1.00 52.36 ? 283 ALA   B CA  1 
ATOM   5133 C C   . ALA   B 1 283 ? 4.909   -10.017 -63.935 1.00 48.24 ? 283 ALA   B C   1 
ATOM   5134 O O   . ALA   B 1 283 ? 4.148   -9.139  -63.512 1.00 45.70 ? 283 ALA   B O   1 
ATOM   5135 C CB  . ALA   B 1 283 ? 4.240   -11.332 -65.963 1.00 48.95 ? 283 ALA   B CB  1 
ATOM   5136 N N   . VAL   B 1 284 ? 5.575   -10.838 -63.120 1.00 48.34 ? 284 VAL   B N   1 
ATOM   5137 C CA  . VAL   B 1 284 ? 5.487   -10.686 -61.671 1.00 51.47 ? 284 VAL   B CA  1 
ATOM   5138 C C   . VAL   B 1 284 ? 6.117   -9.368  -61.236 1.00 50.23 ? 284 VAL   B C   1 
ATOM   5139 O O   . VAL   B 1 284 ? 5.590   -8.668  -60.363 1.00 49.41 ? 284 VAL   B O   1 
ATOM   5140 C CB  . VAL   B 1 284 ? 6.143   -11.890 -60.966 1.00 46.44 ? 284 VAL   B CB  1 
ATOM   5141 C CG1 . VAL   B 1 284 ? 6.077   -11.725 -59.457 1.00 46.39 ? 284 VAL   B CG1 1 
ATOM   5142 C CG2 . VAL   B 1 284 ? 5.465   -13.185 -61.385 1.00 41.72 ? 284 VAL   B CG2 1 
ATOM   5143 N N   . GLU   B 1 285 ? 7.253   -9.007  -61.837 1.00 50.44 ? 285 GLU   B N   1 
ATOM   5144 C CA  . GLU   B 1 285 ? 7.882   -7.730  -61.517 1.00 50.68 ? 285 GLU   B CA  1 
ATOM   5145 C C   . GLU   B 1 285 ? 7.006   -6.561  -61.942 1.00 50.57 ? 285 GLU   B C   1 
ATOM   5146 O O   . GLU   B 1 285 ? 7.006   -5.514  -61.284 1.00 49.64 ? 285 GLU   B O   1 
ATOM   5147 C CB  . GLU   B 1 285 ? 9.257   -7.635  -62.185 1.00 52.87 ? 285 GLU   B CB  1 
ATOM   5148 C CG  . GLU   B 1 285 ? 10.297  -8.581  -61.614 1.00 56.39 ? 285 GLU   B CG  1 
ATOM   5149 C CD  . GLU   B 1 285 ? 11.638  -8.432  -62.296 1.00 63.91 ? 285 GLU   B CD  1 
ATOM   5150 O OE1 . GLU   B 1 285 ? 11.704  -7.724  -63.322 1.00 60.09 ? 285 GLU   B OE1 1 
ATOM   5151 O OE2 . GLU   B 1 285 ? 12.625  -9.016  -61.808 1.00 63.23 ? 285 GLU   B OE2 1 
ATOM   5152 N N   . ARG   B 1 286 ? 6.256   -6.718  -63.034 1.00 51.91 ? 286 ARG   B N   1 
ATOM   5153 C CA  . ARG   B 1 286 ? 5.383   -5.641  -63.484 1.00 52.82 ? 286 ARG   B CA  1 
ATOM   5154 C C   . ARG   B 1 286 ? 4.258   -5.399  -62.485 1.00 52.19 ? 286 ARG   B C   1 
ATOM   5155 O O   . ARG   B 1 286 ? 3.892   -4.248  -62.215 1.00 49.67 ? 286 ARG   B O   1 
ATOM   5156 C CB  . ARG   B 1 286 ? 4.826   -5.970  -64.871 1.00 52.26 ? 286 ARG   B CB  1 
ATOM   5157 C CG  . ARG   B 1 286 ? 3.905   -4.910  -65.447 1.00 57.75 ? 286 ARG   B CG  1 
ATOM   5158 C CD  . ARG   B 1 286 ? 3.755   -5.077  -66.947 1.00 56.82 ? 286 ARG   B CD  1 
ATOM   5159 N NE  . ARG   B 1 286 ? 3.647   -6.480  -67.328 1.00 60.21 ? 286 ARG   B NE  1 
ATOM   5160 C CZ  . ARG   B 1 286 ? 2.515   -7.169  -67.350 1.00 61.05 ? 286 ARG   B CZ  1 
ATOM   5161 N NH1 . ARG   B 1 286 ? 1.363   -6.615  -67.013 1.00 58.45 ? 286 ARG   B NH1 1 
ATOM   5162 N NH2 . ARG   B 1 286 ? 2.541   -8.447  -67.715 1.00 57.82 ? 286 ARG   B NH2 1 
ATOM   5163 N N   . ALA   B 1 287 ? 3.705   -6.473  -61.916 1.00 48.66 ? 287 ALA   B N   1 
ATOM   5164 C CA  . ALA   B 1 287 ? 2.682   -6.317  -60.889 1.00 49.35 ? 287 ALA   B CA  1 
ATOM   5165 C C   . ALA   B 1 287 ? 3.258   -5.660  -59.642 1.00 49.51 ? 287 ALA   B C   1 
ATOM   5166 O O   . ALA   B 1 287 ? 2.606   -4.811  -59.020 1.00 47.30 ? 287 ALA   B O   1 
ATOM   5167 C CB  . ALA   B 1 287 ? 2.065   -7.676  -60.548 1.00 48.20 ? 287 ALA   B CB  1 
ATOM   5168 N N   . ALA   B 1 288 ? 4.485   -6.028  -59.269 1.00 47.83 ? 288 ALA   B N   1 
ATOM   5169 C CA  . ALA   B 1 288 ? 5.104   -5.436  -58.088 1.00 50.35 ? 288 ALA   B CA  1 
ATOM   5170 C C   . ALA   B 1 288 ? 5.391   -3.955  -58.302 1.00 49.51 ? 288 ALA   B C   1 
ATOM   5171 O O   . ALA   B 1 288 ? 5.135   -3.127  -57.421 1.00 51.11 ? 288 ALA   B O   1 
ATOM   5172 C CB  . ALA   B 1 288 ? 6.384   -6.191  -57.735 1.00 50.10 ? 288 ALA   B CB  1 
ATOM   5173 N N   . ALA   B 1 289 ? 5.918   -3.603  -59.479 1.00 52.27 ? 289 ALA   B N   1 
ATOM   5174 C CA  . ALA   B 1 289 ? 6.256   -2.210  -59.750 1.00 50.94 ? 289 ALA   B CA  1 
ATOM   5175 C C   . ALA   B 1 289 ? 5.019   -1.325  -59.797 1.00 51.76 ? 289 ALA   B C   1 
ATOM   5176 O O   . ALA   B 1 289 ? 5.084   -0.149  -59.419 1.00 51.72 ? 289 ALA   B O   1 
ATOM   5177 C CB  . ALA   B 1 289 ? 7.034   -2.104  -61.062 1.00 48.19 ? 289 ALA   B CB  1 
ATOM   5178 N N   . ALA   B 1 290 ? 3.887   -1.864  -60.255 1.00 50.62 ? 290 ALA   B N   1 
ATOM   5179 C CA  . ALA   B 1 290 ? 2.666   -1.068  -60.328 1.00 53.04 ? 290 ALA   B CA  1 
ATOM   5180 C C   . ALA   B 1 290 ? 2.087   -0.798  -58.946 1.00 53.94 ? 290 ALA   B C   1 
ATOM   5181 O O   . ALA   B 1 290 ? 1.463   0.248   -58.729 1.00 57.72 ? 290 ALA   B O   1 
ATOM   5182 C CB  . ALA   B 1 290 ? 1.634   -1.766  -61.211 1.00 53.12 ? 290 ALA   B CB  1 
ATOM   5183 N N   . CYS   B 1 291 ? 2.269   -1.730  -58.008 1.00 50.90 ? 291 CYS   B N   1 
ATOM   5184 C CA  . CYS   B 1 291 ? 1.907   -1.459  -56.621 1.00 52.33 ? 291 CYS   B CA  1 
ATOM   5185 C C   . CYS   B 1 291 ? 2.864   -0.453  -55.997 1.00 53.85 ? 291 CYS   B C   1 
ATOM   5186 O O   . CYS   B 1 291 ? 2.452   0.394   -55.196 1.00 52.87 ? 291 CYS   B O   1 
ATOM   5187 C CB  . CYS   B 1 291 ? 1.895   -2.760  -55.822 1.00 51.12 ? 291 CYS   B CB  1 
ATOM   5188 S SG  . CYS   B 1 291 ? 0.750   -4.006  -56.453 1.00 53.54 ? 291 CYS   B SG  1 
ATOM   5189 N N   . GLU   B 1 292 ? 4.147   -0.532  -56.360 1.00 55.34 ? 292 GLU   B N   1 
ATOM   5190 C CA  . GLU   B 1 292 ? 5.122   0.435   -55.868 1.00 54.37 ? 292 GLU   B CA  1 
ATOM   5191 C C   . GLU   B 1 292 ? 4.777   1.844   -56.337 1.00 52.45 ? 292 GLU   B C   1 
ATOM   5192 O O   . GLU   B 1 292 ? 5.006   2.822   -55.616 1.00 51.51 ? 292 GLU   B O   1 
ATOM   5193 C CB  . GLU   B 1 292 ? 6.523   0.029   -56.326 1.00 50.66 ? 292 GLU   B CB  1 
ATOM   5194 C CG  . GLU   B 1 292 ? 7.666   0.759   -55.642 1.00 56.26 ? 292 GLU   B CG  1 
ATOM   5195 C CD  . GLU   B 1 292 ? 9.005   0.116   -55.937 1.00 64.63 ? 292 GLU   B CD  1 
ATOM   5196 O OE1 . GLU   B 1 292 ? 9.049   -1.126  -56.057 1.00 63.64 ? 292 GLU   B OE1 1 
ATOM   5197 O OE2 . GLU   B 1 292 ? 10.010  0.847   -56.060 1.00 71.52 ? 292 GLU   B OE2 1 
ATOM   5198 N N   . ALA   B 1 293 ? 4.215   1.966   -57.542 1.00 52.73 ? 293 ALA   B N   1 
ATOM   5199 C CA  . ALA   B 1 293 ? 3.751   3.262   -58.018 1.00 54.51 ? 293 ALA   B CA  1 
ATOM   5200 C C   . ALA   B 1 293 ? 2.492   3.722   -57.294 1.00 56.74 ? 293 ALA   B C   1 
ATOM   5201 O O   . ALA   B 1 293 ? 2.191   4.921   -57.300 1.00 57.65 ? 293 ALA   B O   1 
ATOM   5202 C CB  . ALA   B 1 293 ? 3.501   3.210   -59.526 1.00 56.59 ? 293 ALA   B CB  1 
ATOM   5203 N N   . SER   B 1 294 ? 1.759   2.802   -56.669 1.00 56.12 ? 294 SER   B N   1 
ATOM   5204 C CA  . SER   B 1 294 ? 0.537   3.120   -55.942 1.00 55.08 ? 294 SER   B CA  1 
ATOM   5205 C C   . SER   B 1 294 ? 0.778   3.379   -54.459 1.00 52.56 ? 294 SER   B C   1 
ATOM   5206 O O   . SER   B 1 294 ? -0.189  3.540   -53.706 1.00 51.12 ? 294 SER   B O   1 
ATOM   5207 C CB  . SER   B 1 294 ? -0.481  1.987   -56.106 1.00 56.03 ? 294 SER   B CB  1 
ATOM   5208 O OG  . SER   B 1 294 ? -0.746  1.722   -57.471 1.00 56.40 ? 294 SER   B OG  1 
ATOM   5209 N N   . GLY   B 1 295 ? 2.035   3.418   -54.021 1.00 53.15 ? 295 GLY   B N   1 
ATOM   5210 C CA  . GLY   B 1 295 ? 2.360   3.701   -52.637 1.00 50.53 ? 295 GLY   B CA  1 
ATOM   5211 C C   . GLY   B 1 295 ? 2.866   2.520   -51.838 1.00 49.33 ? 295 GLY   B C   1 
ATOM   5212 O O   . GLY   B 1 295 ? 3.183   2.691   -50.655 1.00 49.80 ? 295 GLY   B O   1 
ATOM   5213 N N   . ALA   B 1 296 ? 2.953   1.333   -52.432 1.00 50.39 ? 296 ALA   B N   1 
ATOM   5214 C CA  . ALA   B 1 296 ? 3.441   0.166   -51.717 1.00 51.19 ? 296 ALA   B CA  1 
ATOM   5215 C C   . ALA   B 1 296 ? 4.962   0.107   -51.757 1.00 51.88 ? 296 ALA   B C   1 
ATOM   5216 O O   . ALA   B 1 296 ? 5.604   0.630   -52.672 1.00 50.35 ? 296 ALA   B O   1 
ATOM   5217 C CB  . ALA   B 1 296 ? 2.855   -1.115  -52.313 1.00 48.03 ? 296 ALA   B CB  1 
ATOM   5218 N N   . THR   B 1 297 ? 5.538   -0.536  -50.747 1.00 51.05 ? 297 THR   B N   1 
ATOM   5219 C CA  . THR   B 1 297 ? 6.974   -0.769  -50.682 1.00 50.92 ? 297 THR   B CA  1 
ATOM   5220 C C   . THR   B 1 297 ? 7.252   -2.236  -50.980 1.00 50.95 ? 297 THR   B C   1 
ATOM   5221 O O   . THR   B 1 297 ? 6.552   -3.122  -50.484 1.00 50.16 ? 297 THR   B O   1 
ATOM   5222 C CB  . THR   B 1 297 ? 7.538   -0.385  -49.310 1.00 50.36 ? 297 THR   B CB  1 
ATOM   5223 O OG1 . THR   B 1 297 ? 7.164   -1.373  -48.342 1.00 52.98 ? 297 THR   B OG1 1 
ATOM   5224 C CG2 . THR   B 1 297 ? 6.985   0.971   -48.880 1.00 49.86 ? 297 THR   B CG2 1 
ATOM   5225 N N   . VAL   B 1 298 ? 8.267   -2.489  -51.801 1.00 50.20 ? 298 VAL   B N   1 
ATOM   5226 C CA  . VAL   B 1 298 ? 8.558   -3.822  -52.312 1.00 49.07 ? 298 VAL   B CA  1 
ATOM   5227 C C   . VAL   B 1 298 ? 9.977   -4.202  -51.914 1.00 49.51 ? 298 VAL   B C   1 
ATOM   5228 O O   . VAL   B 1 298 ? 10.908  -3.404  -52.075 1.00 50.08 ? 298 VAL   B O   1 
ATOM   5229 C CB  . VAL   B 1 298 ? 8.377   -3.890  -53.839 1.00 48.99 ? 298 VAL   B CB  1 
ATOM   5230 C CG1 . VAL   B 1 298 ? 8.791   -5.251  -54.369 1.00 49.54 ? 298 VAL   B CG1 1 
ATOM   5231 C CG2 . VAL   B 1 298 ? 6.931   -3.586  -54.210 1.00 49.74 ? 298 VAL   B CG2 1 
ATOM   5232 N N   . ALA   B 1 299 ? 10.132  -5.414  -51.385 1.00 46.79 ? 299 ALA   B N   1 
ATOM   5233 C CA  . ALA   B 1 299 ? 11.429  -5.992  -51.073 1.00 47.65 ? 299 ALA   B CA  1 
ATOM   5234 C C   . ALA   B 1 299 ? 11.632  -7.249  -51.908 1.00 47.99 ? 299 ALA   B C   1 
ATOM   5235 O O   . ALA   B 1 299 ? 10.671  -7.876  -52.361 1.00 49.03 ? 299 ALA   B O   1 
ATOM   5236 C CB  . ALA   B 1 299 ? 11.553  -6.324  -49.581 1.00 43.27 ? 299 ALA   B CB  1 
ATOM   5237 N N   . THR   B 1 300 ? 12.899  -7.611  -52.110 1.00 48.37 ? 300 THR   B N   1 
ATOM   5238 C CA  . THR   B 1 300 ? 13.266  -8.785  -52.891 1.00 48.08 ? 300 THR   B CA  1 
ATOM   5239 C C   . THR   B 1 300 ? 13.954  -9.855  -52.054 1.00 48.44 ? 300 THR   B C   1 
ATOM   5240 O O   . THR   B 1 300 ? 14.406  -10.863 -52.605 1.00 48.90 ? 300 THR   B O   1 
ATOM   5241 C CB  . THR   B 1 300 ? 14.166  -8.389  -54.064 1.00 50.79 ? 300 THR   B CB  1 
ATOM   5242 O OG1 . THR   B 1 300 ? 15.359  -7.769  -53.568 1.00 50.32 ? 300 THR   B OG1 1 
ATOM   5243 C CG2 . THR   B 1 300 ? 13.442  -7.427  -54.995 1.00 50.55 ? 300 THR   B CG2 1 
ATOM   5244 N N   . SER   B 1 301 ? 14.047  -9.660  -50.741 1.00 52.25 ? 301 SER   B N   1 
ATOM   5245 C CA  . SER   B 1 301 ? 14.667  -10.628 -49.843 1.00 50.97 ? 301 SER   B CA  1 
ATOM   5246 C C   . SER   B 1 301 ? 14.274  -10.275 -48.414 1.00 52.21 ? 301 SER   B C   1 
ATOM   5247 O O   . SER   B 1 301 ? 13.799  -9.170  -48.135 1.00 52.64 ? 301 SER   B O   1 
ATOM   5248 C CB  . SER   B 1 301 ? 16.191  -10.653 -50.001 1.00 52.02 ? 301 SER   B CB  1 
ATOM   5249 O OG  . SER   B 1 301 ? 16.748  -9.369  -49.780 1.00 55.47 ? 301 SER   B OG  1 
ATOM   5250 N N   . SER   B 1 302 ? 14.479  -11.234 -47.510 1.00 51.99 ? 302 SER   B N   1 
ATOM   5251 C CA  . SER   B 1 302 ? 14.163  -11.061 -46.098 1.00 53.66 ? 302 SER   B CA  1 
ATOM   5252 C C   . SER   B 1 302 ? 14.873  -12.124 -45.268 1.00 54.44 ? 302 SER   B C   1 
ATOM   5253 O O   . SER   B 1 302 ? 14.864  -13.305 -45.638 1.00 52.84 ? 302 SER   B O   1 
ATOM   5254 C CB  . SER   B 1 302 ? 12.653  -11.139 -45.866 1.00 53.42 ? 302 SER   B CB  1 
ATOM   5255 O OG  . SER   B 1 302 ? 12.347  -11.202 -44.483 1.00 50.69 ? 302 SER   B OG  1 
ATOM   5256 N N   . PRO   B 1 303 ? 15.501  -11.751 -44.150 1.00 56.27 ? 303 PRO   B N   1 
ATOM   5257 C CA  . PRO   B 1 303 ? 16.087  -12.775 -43.269 1.00 54.21 ? 303 PRO   B CA  1 
ATOM   5258 C C   . PRO   B 1 303 ? 15.051  -13.691 -42.647 1.00 56.43 ? 303 PRO   B C   1 
ATOM   5259 O O   . PRO   B 1 303 ? 15.396  -14.809 -42.243 1.00 57.30 ? 303 PRO   B O   1 
ATOM   5260 C CB  . PRO   B 1 303 ? 16.818  -11.947 -42.203 1.00 52.36 ? 303 PRO   B CB  1 
ATOM   5261 C CG  . PRO   B 1 303 ? 16.130  -10.623 -42.212 1.00 53.55 ? 303 PRO   B CG  1 
ATOM   5262 C CD  . PRO   B 1 303 ? 15.728  -10.387 -43.642 1.00 55.20 ? 303 PRO   B CD  1 
ATOM   5263 N N   . ASP   B 1 304 ? 13.794  -13.258 -42.561 1.00 56.55 ? 304 ASP   B N   1 
ATOM   5264 C CA  . ASP   B 1 304 ? 12.716  -14.072 -42.020 1.00 55.38 ? 304 ASP   B CA  1 
ATOM   5265 C C   . ASP   B 1 304 ? 12.039  -14.928 -43.083 1.00 55.53 ? 304 ASP   B C   1 
ATOM   5266 O O   . ASP   B 1 304 ? 10.912  -15.391 -42.872 1.00 57.02 ? 304 ASP   B O   1 
ATOM   5267 C CB  . ASP   B 1 304 ? 11.689  -13.183 -41.317 1.00 54.41 ? 304 ASP   B CB  1 
ATOM   5268 C CG  . ASP   B 1 304 ? 12.288  -12.419 -40.153 1.00 58.42 ? 304 ASP   B CG  1 
ATOM   5269 O OD1 . ASP   B 1 304 ? 13.262  -12.921 -39.552 1.00 61.62 ? 304 ASP   B OD1 1 
ATOM   5270 O OD2 . ASP   B 1 304 ? 11.788  -11.320 -39.838 1.00 58.81 ? 304 ASP   B OD2 1 
ATOM   5271 N N   . LEU   B 1 305 ? 12.696  -15.146 -44.219 1.00 55.06 ? 305 LEU   B N   1 
ATOM   5272 C CA  . LEU   B 1 305 ? 12.173  -16.046 -45.234 1.00 52.44 ? 305 LEU   B CA  1 
ATOM   5273 C C   . LEU   B 1 305 ? 12.628  -17.465 -44.926 1.00 51.54 ? 305 LEU   B C   1 
ATOM   5274 O O   . LEU   B 1 305 ? 13.840  -17.708 -44.836 1.00 51.54 ? 305 LEU   B O   1 
ATOM   5275 C CB  . LEU   B 1 305 ? 12.644  -15.633 -46.619 1.00 52.13 ? 305 LEU   B CB  1 
ATOM   5276 C CG  . LEU   B 1 305 ? 12.007  -16.369 -47.802 1.00 53.73 ? 305 LEU   B CG  1 
ATOM   5277 C CD1 . LEU   B 1 305 ? 10.560  -15.934 -48.004 1.00 54.69 ? 305 LEU   B CD1 1 
ATOM   5278 C CD2 . LEU   B 1 305 ? 12.817  -16.160 -49.071 1.00 55.32 ? 305 LEU   B CD2 1 
ATOM   5279 N N   . PRO   B 1 306 ? 11.715  -18.415 -44.744 1.00 48.35 ? 306 PRO   B N   1 
ATOM   5280 C CA  . PRO   B 1 306 ? 12.125  -19.786 -44.425 1.00 47.92 ? 306 PRO   B CA  1 
ATOM   5281 C C   . PRO   B 1 306 ? 12.898  -20.423 -45.570 1.00 49.45 ? 306 PRO   B C   1 
ATOM   5282 O O   . PRO   B 1 306 ? 12.833  -19.990 -46.726 1.00 49.09 ? 306 PRO   B O   1 
ATOM   5283 C CB  . PRO   B 1 306 ? 10.793  -20.509 -44.180 1.00 47.92 ? 306 PRO   B CB  1 
ATOM   5284 C CG  . PRO   B 1 306 ? 9.805   -19.408 -43.890 1.00 46.47 ? 306 PRO   B CG  1 
ATOM   5285 C CD  . PRO   B 1 306 ? 10.254  -18.256 -44.733 1.00 47.46 ? 306 PRO   B CD  1 
ATOM   5286 N N   . ASP   B 1 307 ? 13.655  -21.463 -45.220 1.00 45.31 ? 307 ASP   B N   1 
ATOM   5287 C CA  . ASP   B 1 307 ? 14.430  -22.212 -46.201 1.00 46.53 ? 307 ASP   B CA  1 
ATOM   5288 C C   . ASP   B 1 307 ? 13.478  -22.887 -47.178 1.00 49.14 ? 307 ASP   B C   1 
ATOM   5289 O O   . ASP   B 1 307 ? 12.836  -23.886 -46.836 1.00 46.15 ? 307 ASP   B O   1 
ATOM   5290 C CB  . ASP   B 1 307 ? 15.314  -23.236 -45.494 1.00 50.58 ? 307 ASP   B CB  1 
ATOM   5291 C CG  . ASP   B 1 307 ? 16.262  -23.947 -46.445 1.00 49.68 ? 307 ASP   B CG  1 
ATOM   5292 O OD1 . ASP   B 1 307 ? 16.278  -23.605 -47.642 1.00 50.36 ? 307 ASP   B OD1 1 
ATOM   5293 O OD2 . ASP   B 1 307 ? 16.997  -24.850 -45.986 1.00 51.34 ? 307 ASP   B OD2 1 
ATOM   5294 N N   . LEU   B 1 308 ? 13.383  -22.342 -48.395 1.00 49.49 ? 308 LEU   B N   1 
ATOM   5295 C CA  . LEU   B 1 308 ? 12.468  -22.909 -49.379 1.00 47.05 ? 308 LEU   B CA  1 
ATOM   5296 C C   . LEU   B 1 308 ? 12.944  -24.267 -49.880 1.00 48.34 ? 308 LEU   B C   1 
ATOM   5297 O O   . LEU   B 1 308 ? 12.126  -25.079 -50.329 1.00 48.51 ? 308 LEU   B O   1 
ATOM   5298 C CB  . LEU   B 1 308 ? 12.285  -21.943 -50.545 1.00 48.37 ? 308 LEU   B CB  1 
ATOM   5299 C CG  . LEU   B 1 308 ? 11.656  -20.595 -50.179 1.00 48.25 ? 308 LEU   B CG  1 
ATOM   5300 C CD1 . LEU   B 1 308 ? 11.458  -19.730 -51.410 1.00 52.31 ? 308 LEU   B CD1 1 
ATOM   5301 C CD2 . LEU   B 1 308 ? 10.335  -20.812 -49.453 1.00 47.85 ? 308 LEU   B CD2 1 
ATOM   5302 N N   . SER   B 1 309 ? 14.252  -24.530 -49.829 1.00 46.65 ? 309 SER   B N   1 
ATOM   5303 C CA  . SER   B 1 309 ? 14.748  -25.856 -50.184 1.00 48.93 ? 309 SER   B CA  1 
ATOM   5304 C C   . SER   B 1 309 ? 14.249  -26.902 -49.196 1.00 50.05 ? 309 SER   B C   1 
ATOM   5305 O O   . SER   B 1 309 ? 13.737  -27.957 -49.591 1.00 49.84 ? 309 SER   B O   1 
ATOM   5306 C CB  . SER   B 1 309 ? 16.276  -25.855 -50.241 1.00 49.95 ? 309 SER   B CB  1 
ATOM   5307 O OG  . SER   B 1 309 ? 16.742  -25.214 -51.414 1.00 56.99 ? 309 SER   B OG  1 
ATOM   5308 N N   . ALA   B 1 310 ? 14.387  -26.621 -47.898 1.00 48.11 ? 310 ALA   B N   1 
ATOM   5309 C CA  . ALA   B 1 310 ? 13.895  -27.545 -46.883 1.00 50.23 ? 310 ALA   B CA  1 
ATOM   5310 C C   . ALA   B 1 310 ? 12.376  -27.644 -46.917 1.00 49.05 ? 310 ALA   B C   1 
ATOM   5311 O O   . ALA   B 1 310 ? 11.810  -28.712 -46.656 1.00 51.29 ? 310 ALA   B O   1 
ATOM   5312 C CB  . ALA   B 1 310 ? 14.374  -27.106 -45.501 1.00 46.42 ? 310 ALA   B CB  1 
ATOM   5313 N N   . LEU   B 1 311 ? 11.699  -26.539 -47.239 1.00 46.16 ? 311 LEU   B N   1 
ATOM   5314 C CA  . LEU   B 1 311 ? 10.239  -26.538 -47.250 1.00 46.82 ? 311 LEU   B CA  1 
ATOM   5315 C C   . LEU   B 1 311 ? 9.698   -27.475 -48.322 1.00 47.11 ? 311 LEU   B C   1 
ATOM   5316 O O   . LEU   B 1 311 ? 8.822   -28.306 -48.052 1.00 47.27 ? 311 LEU   B O   1 
ATOM   5317 C CB  . LEU   B 1 311 ? 9.720   -25.113 -47.462 1.00 45.90 ? 311 LEU   B CB  1 
ATOM   5318 C CG  . LEU   B 1 311 ? 8.243   -24.803 -47.194 1.00 44.04 ? 311 LEU   B CG  1 
ATOM   5319 C CD1 . LEU   B 1 311 ? 8.087   -23.329 -46.913 1.00 47.86 ? 311 LEU   B CD1 1 
ATOM   5320 C CD2 . LEU   B 1 311 ? 7.339   -25.202 -48.359 1.00 45.84 ? 311 LEU   B CD2 1 
ATOM   5321 N N   . VAL   B 1 312 ? 10.204  -27.351 -49.552 1.00 48.47 ? 312 VAL   B N   1 
ATOM   5322 C CA  . VAL   B 1 312 ? 9.691   -28.178 -50.638 1.00 48.92 ? 312 VAL   B CA  1 
ATOM   5323 C C   . VAL   B 1 312 ? 10.059  -29.641 -50.422 1.00 47.72 ? 312 VAL   B C   1 
ATOM   5324 O O   . VAL   B 1 312 ? 9.363   -30.541 -50.909 1.00 50.41 ? 312 VAL   B O   1 
ATOM   5325 C CB  . VAL   B 1 312 ? 10.194  -27.654 -51.998 1.00 49.44 ? 312 VAL   B CB  1 
ATOM   5326 C CG1 . VAL   B 1 312 ? 11.567  -28.222 -52.336 1.00 50.22 ? 312 VAL   B CG1 1 
ATOM   5327 C CG2 . VAL   B 1 312 ? 9.188   -27.977 -53.089 1.00 45.90 ? 312 VAL   B CG2 1 
ATOM   5328 N N   . ALA   B 1 313 ? 11.142  -29.908 -49.689 1.00 49.37 ? 313 ALA   B N   1 
ATOM   5329 C CA  . ALA   B 1 313 ? 11.485  -31.287 -49.364 1.00 50.68 ? 313 ALA   B CA  1 
ATOM   5330 C C   . ALA   B 1 313 ? 10.536  -31.843 -48.310 1.00 52.10 ? 313 ALA   B C   1 
ATOM   5331 O O   . ALA   B 1 313 ? 10.052  -32.974 -48.431 1.00 50.91 ? 313 ALA   B O   1 
ATOM   5332 C CB  . ALA   B 1 313 ? 12.935  -31.371 -48.889 1.00 49.55 ? 313 ALA   B CB  1 
ATOM   5333 N N   . ASP   B 1 314 ? 10.253  -31.054 -47.271 1.00 49.37 ? 314 ASP   B N   1 
ATOM   5334 C CA  . ASP   B 1 314 ? 9.304   -31.485 -46.248 1.00 49.15 ? 314 ASP   B CA  1 
ATOM   5335 C C   . ASP   B 1 314 ? 7.897   -31.616 -46.817 1.00 48.17 ? 314 ASP   B C   1 
ATOM   5336 O O   . ASP   B 1 314 ? 7.147   -32.519 -46.430 1.00 50.95 ? 314 ASP   B O   1 
ATOM   5337 C CB  . ASP   B 1 314 ? 9.312   -30.504 -45.073 1.00 51.30 ? 314 ASP   B CB  1 
ATOM   5338 C CG  . ASP   B 1 314 ? 10.549  -30.635 -44.209 1.00 53.56 ? 314 ASP   B CG  1 
ATOM   5339 O OD1 . ASP   B 1 314 ? 11.319  -31.598 -44.411 1.00 52.57 ? 314 ASP   B OD1 1 
ATOM   5340 O OD2 . ASP   B 1 314 ? 10.754  -29.773 -43.328 1.00 56.83 ? 314 ASP   B OD2 1 
ATOM   5341 N N   . TYR   B 1 315 ? 7.519   -30.727 -47.737 1.00 46.73 ? 315 TYR   B N   1 
ATOM   5342 C CA  . TYR   B 1 315 ? 6.157   -30.743 -48.262 1.00 44.09 ? 315 TYR   B CA  1 
ATOM   5343 C C   . TYR   B 1 315 ? 5.909   -31.969 -49.136 1.00 47.52 ? 315 TYR   B C   1 
ATOM   5344 O O   . TYR   B 1 315 ? 4.888   -32.650 -48.988 1.00 47.79 ? 315 TYR   B O   1 
ATOM   5345 C CB  . TYR   B 1 315 ? 5.876   -29.459 -49.044 1.00 45.03 ? 315 TYR   B CB  1 
ATOM   5346 C CG  . TYR   B 1 315 ? 4.762   -29.607 -50.054 1.00 42.45 ? 315 TYR   B CG  1 
ATOM   5347 C CD1 . TYR   B 1 315 ? 3.436   -29.687 -49.650 1.00 42.37 ? 315 TYR   B CD1 1 
ATOM   5348 C CD2 . TYR   B 1 315 ? 5.036   -29.672 -51.414 1.00 44.94 ? 315 TYR   B CD2 1 
ATOM   5349 C CE1 . TYR   B 1 315 ? 2.415   -29.829 -50.571 1.00 44.40 ? 315 TYR   B CE1 1 
ATOM   5350 C CE2 . TYR   B 1 315 ? 4.021   -29.810 -52.343 1.00 45.18 ? 315 TYR   B CE2 1 
ATOM   5351 C CZ  . TYR   B 1 315 ? 2.713   -29.888 -51.916 1.00 45.36 ? 315 TYR   B CZ  1 
ATOM   5352 O OH  . TYR   B 1 315 ? 1.703   -30.024 -52.841 1.00 43.17 ? 315 TYR   B OH  1 
ATOM   5353 N N   . THR   B 1 316 ? 6.831   -32.260 -50.061 1.00 45.62 ? 316 THR   B N   1 
ATOM   5354 C CA  . THR   B 1 316 ? 6.645   -33.394 -50.964 1.00 46.97 ? 316 THR   B CA  1 
ATOM   5355 C C   . THR   B 1 316 ? 6.721   -34.726 -50.229 1.00 44.18 ? 316 THR   B C   1 
ATOM   5356 O O   . THR   B 1 316 ? 6.127   -35.713 -50.678 1.00 47.35 ? 316 THR   B O   1 
ATOM   5357 C CB  . THR   B 1 316 ? 7.685   -33.361 -52.083 1.00 45.86 ? 316 THR   B CB  1 
ATOM   5358 O OG1 . THR   B 1 316 ? 8.988   -33.162 -51.520 1.00 51.32 ? 316 THR   B OG1 1 
ATOM   5359 C CG2 . THR   B 1 316 ? 7.389   -32.238 -53.059 1.00 50.19 ? 316 THR   B CG2 1 
ATOM   5360 N N   . ARG   B 1 317 ? 7.456   -34.782 -49.116 1.00 46.94 ? 317 ARG   B N   1 
ATOM   5361 C CA  . ARG   B 1 317 ? 7.455   -35.989 -48.296 1.00 48.25 ? 317 ARG   B CA  1 
ATOM   5362 C C   . ARG   B 1 317 ? 6.090   -36.206 -47.660 1.00 46.21 ? 317 ARG   B C   1 
ATOM   5363 O O   . ARG   B 1 317 ? 5.557   -37.322 -47.670 1.00 47.45 ? 317 ARG   B O   1 
ATOM   5364 C CB  . ARG   B 1 317 ? 8.540   -35.903 -47.222 1.00 50.46 ? 317 ARG   B CB  1 
ATOM   5365 C CG  . ARG   B 1 317 ? 8.608   -37.135 -46.327 1.00 56.12 ? 317 ARG   B CG  1 
ATOM   5366 C CD  . ARG   B 1 317 ? 9.597   -36.972 -45.182 1.00 60.34 ? 317 ARG   B CD  1 
ATOM   5367 N NE  . ARG   B 1 317 ? 10.797  -36.245 -45.578 1.00 67.27 ? 317 ARG   B NE  1 
ATOM   5368 C CZ  . ARG   B 1 317 ? 11.174  -35.084 -45.063 1.00 64.04 ? 317 ARG   B CZ  1 
ATOM   5369 N NH1 . ARG   B 1 317 ? 10.490  -34.504 -44.091 1.00 59.14 ? 317 ARG   B NH1 1 
ATOM   5370 N NH2 . ARG   B 1 317 ? 12.268  -34.491 -45.531 1.00 56.16 ? 317 ARG   B NH2 1 
ATOM   5371 N N   . MET   B 1 318 ? 5.507   -35.143 -47.102 1.00 43.79 ? 318 MET   B N   1 
ATOM   5372 C CA  . MET   B 1 318 ? 4.181   -35.252 -46.506 1.00 43.08 ? 318 MET   B CA  1 
ATOM   5373 C C   . MET   B 1 318 ? 3.114   -35.463 -47.573 1.00 42.70 ? 318 MET   B C   1 
ATOM   5374 O O   . MET   B 1 318 ? 2.154   -36.212 -47.360 1.00 40.65 ? 318 MET   B O   1 
ATOM   5375 C CB  . MET   B 1 318 ? 3.879   -34.004 -45.675 1.00 48.37 ? 318 MET   B CB  1 
ATOM   5376 C CG  . MET   B 1 318 ? 2.486   -33.980 -45.070 1.00 43.57 ? 318 MET   B CG  1 
ATOM   5377 S SD  . MET   B 1 318 ? 2.191   -32.582 -43.970 1.00 45.38 ? 318 MET   B SD  1 
ATOM   5378 C CE  . MET   B 1 318 ? 3.262   -33.000 -42.596 1.00 45.70 ? 318 MET   B CE  1 
ATOM   5379 N N   . LEU   B 1 319 ? 3.275   -34.818 -48.731 1.00 46.27 ? 319 LEU   B N   1 
ATOM   5380 C CA  . LEU   B 1 319 ? 2.303   -34.954 -49.813 1.00 43.48 ? 319 LEU   B CA  1 
ATOM   5381 C C   . LEU   B 1 319 ? 2.183   -36.404 -50.271 1.00 43.89 ? 319 LEU   B C   1 
ATOM   5382 O O   . LEU   B 1 319 ? 1.073   -36.920 -50.445 1.00 42.98 ? 319 LEU   B O   1 
ATOM   5383 C CB  . LEU   B 1 319 ? 2.700   -34.048 -50.979 1.00 44.32 ? 319 LEU   B CB  1 
ATOM   5384 C CG  . LEU   B 1 319 ? 1.934   -34.205 -52.291 1.00 47.99 ? 319 LEU   B CG  1 
ATOM   5385 C CD1 . LEU   B 1 319 ? 0.476   -33.813 -52.118 1.00 46.02 ? 319 LEU   B CD1 1 
ATOM   5386 C CD2 . LEU   B 1 319 ? 2.596   -33.385 -53.385 1.00 47.91 ? 319 LEU   B CD2 1 
ATOM   5387 N N   . LEU   B 1 320 ? 3.319   -37.077 -50.474 1.00 43.01 ? 320 LEU   B N   1 
ATOM   5388 C CA  . LEU   B 1 320 ? 3.282   -38.469 -50.915 1.00 42.82 ? 320 LEU   B CA  1 
ATOM   5389 C C   . LEU   B 1 320 ? 2.655   -39.367 -49.859 1.00 44.58 ? 320 LEU   B C   1 
ATOM   5390 O O   . LEU   B 1 320 ? 1.908   -40.296 -50.186 1.00 41.21 ? 320 LEU   B O   1 
ATOM   5391 C CB  . LEU   B 1 320 ? 4.690   -38.961 -51.253 1.00 42.93 ? 320 LEU   B CB  1 
ATOM   5392 C CG  . LEU   B 1 320 ? 5.348   -38.443 -52.532 1.00 48.64 ? 320 LEU   B CG  1 
ATOM   5393 C CD1 . LEU   B 1 320 ? 6.384   -39.443 -53.041 1.00 47.22 ? 320 LEU   B CD1 1 
ATOM   5394 C CD2 . LEU   B 1 320 ? 4.316   -38.133 -53.601 1.00 44.04 ? 320 LEU   B CD2 1 
ATOM   5395 N N   . VAL   B 1 321 ? 2.948   -39.105 -48.585 1.00 43.89 ? 321 VAL   B N   1 
ATOM   5396 C CA  . VAL   B 1 321 ? 2.403   -39.930 -47.513 1.00 43.95 ? 321 VAL   B CA  1 
ATOM   5397 C C   . VAL   B 1 321 ? 0.894   -39.745 -47.410 1.00 43.58 ? 321 VAL   B C   1 
ATOM   5398 O O   . VAL   B 1 321 ? 0.151   -40.712 -47.199 1.00 45.90 ? 321 VAL   B O   1 
ATOM   5399 C CB  . VAL   B 1 321 ? 3.120   -39.611 -46.187 1.00 44.55 ? 321 VAL   B CB  1 
ATOM   5400 C CG1 . VAL   B 1 321 ? 2.395   -40.245 -45.019 1.00 39.96 ? 321 VAL   B CG1 1 
ATOM   5401 C CG2 . VAL   B 1 321 ? 4.563   -40.098 -46.241 1.00 43.47 ? 321 VAL   B CG2 1 
ATOM   5402 N N   . VAL   B 1 322 ? 0.414   -38.511 -47.573 1.00 42.49 ? 322 VAL   B N   1 
ATOM   5403 C CA  . VAL   B 1 322 ? -1.025  -38.265 -47.523 1.00 43.93 ? 322 VAL   B CA  1 
ATOM   5404 C C   . VAL   B 1 322 ? -1.719  -38.935 -48.702 1.00 45.95 ? 322 VAL   B C   1 
ATOM   5405 O O   . VAL   B 1 322 ? -2.760  -39.583 -48.543 1.00 45.22 ? 322 VAL   B O   1 
ATOM   5406 C CB  . VAL   B 1 322 ? -1.311  -36.751 -47.480 1.00 44.87 ? 322 VAL   B CB  1 
ATOM   5407 C CG1 . VAL   B 1 322 ? -2.804  -36.488 -47.610 1.00 45.69 ? 322 VAL   B CG1 1 
ATOM   5408 C CG2 . VAL   B 1 322 ? -0.783  -36.143 -46.190 1.00 46.09 ? 322 VAL   B CG2 1 
ATOM   5409 N N   . LEU   B 1 323 ? -1.148  -38.802 -49.902 1.00 43.98 ? 323 LEU   B N   1 
ATOM   5410 C CA  . LEU   B 1 323 ? -1.749  -39.415 -51.083 1.00 45.89 ? 323 LEU   B CA  1 
ATOM   5411 C C   . LEU   B 1 323 ? -1.708  -40.935 -51.016 1.00 44.36 ? 323 LEU   B C   1 
ATOM   5412 O O   . LEU   B 1 323 ? -2.624  -41.600 -51.514 1.00 44.07 ? 323 LEU   B O   1 
ATOM   5413 C CB  . LEU   B 1 323 ? -1.040  -38.928 -52.347 1.00 45.66 ? 323 LEU   B CB  1 
ATOM   5414 C CG  . LEU   B 1 323 ? -1.227  -37.453 -52.693 1.00 48.19 ? 323 LEU   B CG  1 
ATOM   5415 C CD1 . LEU   B 1 323 ? -0.342  -37.058 -53.862 1.00 46.66 ? 323 LEU   B CD1 1 
ATOM   5416 C CD2 . LEU   B 1 323 ? -2.688  -37.161 -52.996 1.00 42.93 ? 323 LEU   B CD2 1 
ATOM   5417 N N   . ALA   B 1 324 ? -0.664  -41.503 -50.417 1.00 42.99 ? 324 ALA   B N   1 
ATOM   5418 C CA  . ALA   B 1 324 ? -0.561  -42.950 -50.287 1.00 44.99 ? 324 ALA   B CA  1 
ATOM   5419 C C   . ALA   B 1 324 ? -1.358  -43.498 -49.112 1.00 44.33 ? 324 ALA   B C   1 
ATOM   5420 O O   . ALA   B 1 324 ? -1.380  -44.719 -48.922 1.00 44.85 ? 324 ALA   B O   1 
ATOM   5421 C CB  . ALA   B 1 324 ? 0.906   -43.366 -50.149 1.00 42.15 ? 324 ALA   B CB  1 
ATOM   5422 N N   . ARG   B 1 325 ? -2.009  -42.632 -48.331 1.00 42.62 ? 325 ARG   B N   1 
ATOM   5423 C CA  . ARG   B 1 325 ? -2.763  -43.031 -47.141 1.00 46.34 ? 325 ARG   B CA  1 
ATOM   5424 C C   . ARG   B 1 325 ? -1.899  -43.818 -46.159 1.00 46.88 ? 325 ARG   B C   1 
ATOM   5425 O O   . ARG   B 1 325 ? -2.394  -44.678 -45.427 1.00 44.76 ? 325 ARG   B O   1 
ATOM   5426 C CB  . ARG   B 1 325 ? -4.018  -43.826 -47.519 1.00 47.16 ? 325 ARG   B CB  1 
ATOM   5427 C CG  . ARG   B 1 325 ? -5.251  -42.972 -47.738 1.00 44.75 ? 325 ARG   B CG  1 
ATOM   5428 C CD  . ARG   B 1 325 ? -6.308  -43.292 -46.696 1.00 50.22 ? 325 ARG   B CD  1 
ATOM   5429 N NE  . ARG   B 1 325 ? -7.289  -42.225 -46.561 1.00 47.99 ? 325 ARG   B NE  1 
ATOM   5430 C CZ  . ARG   B 1 325 ? -8.197  -42.162 -45.598 1.00 49.44 ? 325 ARG   B CZ  1 
ATOM   5431 N NH1 . ARG   B 1 325 ? -8.284  -43.099 -44.669 1.00 46.14 ? 325 ARG   B NH1 1 
ATOM   5432 N NH2 . ARG   B 1 325 ? -9.035  -41.131 -45.564 1.00 51.71 ? 325 ARG   B NH2 1 
ATOM   5433 N N   . GLY   B 1 326 ? -0.600  -43.522 -46.130 1.00 44.61 ? 326 GLY   B N   1 
ATOM   5434 C CA  . GLY   B 1 326 ? 0.318   -44.200 -45.242 1.00 42.63 ? 326 GLY   B CA  1 
ATOM   5435 C C   . GLY   B 1 326 ? 0.772   -45.567 -45.703 1.00 47.55 ? 326 GLY   B C   1 
ATOM   5436 O O   . GLY   B 1 326 ? 1.517   -46.231 -44.971 1.00 48.01 ? 326 GLY   B O   1 
ATOM   5437 N N   . LEU   B 1 327 ? 0.348   -46.014 -46.883 1.00 47.45 ? 327 LEU   B N   1 
ATOM   5438 C CA  . LEU   B 1 327 ? 0.739   -47.316 -47.401 1.00 50.91 ? 327 LEU   B CA  1 
ATOM   5439 C C   . LEU   B 1 327 ? 2.079   -47.226 -48.118 1.00 55.17 ? 327 LEU   B C   1 
ATOM   5440 O O   . LEU   B 1 327 ? 2.384   -46.227 -48.776 1.00 54.23 ? 327 LEU   B O   1 
ATOM   5441 C CB  . LEU   B 1 327 ? -0.316  -47.868 -48.362 1.00 50.00 ? 327 LEU   B CB  1 
ATOM   5442 C CG  . LEU   B 1 327 ? -1.607  -48.462 -47.792 1.00 50.48 ? 327 LEU   B CG  1 
ATOM   5443 C CD1 . LEU   B 1 327 ? -1.401  -49.002 -46.381 1.00 44.02 ? 327 LEU   B CD1 1 
ATOM   5444 C CD2 . LEU   B 1 327 ? -2.747  -47.455 -47.843 1.00 52.81 ? 327 LEU   B CD2 1 
ATOM   5445 N N   . ALA   B 1 328 ? 2.874   -48.281 -47.980 1.00 55.80 ? 328 ALA   B N   1 
ATOM   5446 C CA  . ALA   B 1 328 ? 4.108   -48.469 -48.715 1.00 62.31 ? 328 ALA   B CA  1 
ATOM   5447 C C   . ALA   B 1 328 ? 4.038   -49.783 -49.482 1.00 70.47 ? 328 ALA   B C   1 
ATOM   5448 O O   . ALA   B 1 328 ? 3.363   -50.720 -49.046 1.00 68.31 ? 328 ALA   B O   1 
ATOM   5449 C CB  . ALA   B 1 328 ? 5.325   -48.483 -47.780 1.00 63.06 ? 328 ALA   B CB  1 
ATOM   5450 N N   . PRO   B 1 329 ? 4.701   -49.879 -50.634 1.00 73.64 ? 329 PRO   B N   1 
ATOM   5451 C CA  . PRO   B 1 329 ? 4.725   -51.155 -51.355 1.00 73.99 ? 329 PRO   B CA  1 
ATOM   5452 C C   . PRO   B 1 329 ? 5.428   -52.226 -50.535 1.00 76.96 ? 329 PRO   B C   1 
ATOM   5453 O O   . PRO   B 1 329 ? 6.236   -51.938 -49.648 1.00 79.00 ? 329 PRO   B O   1 
ATOM   5454 C CB  . PRO   B 1 329 ? 5.500   -50.828 -52.637 1.00 75.76 ? 329 PRO   B CB  1 
ATOM   5455 C CG  . PRO   B 1 329 ? 6.317   -49.626 -52.287 1.00 74.70 ? 329 PRO   B CG  1 
ATOM   5456 C CD  . PRO   B 1 329 ? 5.473   -48.835 -51.331 1.00 71.82 ? 329 PRO   B CD  1 
ATOM   5457 N N   . GLU   B 1 330 ? 5.095   -53.481 -50.833 1.00 79.23 ? 330 GLU   B N   1 
ATOM   5458 C CA  . GLU   B 1 330 ? 5.682   -54.599 -50.108 1.00 81.10 ? 330 GLU   B CA  1 
ATOM   5459 C C   . GLU   B 1 330 ? 7.199   -54.588 -50.251 1.00 81.61 ? 330 GLU   B C   1 
ATOM   5460 O O   . GLU   B 1 330 ? 7.738   -54.309 -51.325 1.00 81.85 ? 330 GLU   B O   1 
ATOM   5461 C CB  . GLU   B 1 330 ? 5.105   -55.922 -50.615 1.00 83.53 ? 330 GLU   B CB  1 
ATOM   5462 C CG  . GLU   B 1 330 ? 3.613   -56.075 -50.358 1.00 86.61 ? 330 GLU   B CG  1 
ATOM   5463 C CD  . GLU   B 1 330 ? 3.073   -57.413 -50.819 1.00 91.65 ? 330 GLU   B CD  1 
ATOM   5464 O OE1 . GLU   B 1 330 ? 3.761   -58.436 -50.620 1.00 92.21 ? 330 GLU   B OE1 1 
ATOM   5465 O OE2 . GLU   B 1 330 ? 1.961   -57.440 -51.386 1.00 95.34 ? 330 GLU   B OE2 1 
ATOM   5466 N N   . GLY   B 1 331 ? 7.886   -54.886 -49.151 1.00 81.97 ? 331 GLY   B N   1 
ATOM   5467 C CA  . GLY   B 1 331 ? 9.324   -54.731 -49.089 1.00 79.90 ? 331 GLY   B CA  1 
ATOM   5468 C C   . GLY   B 1 331 ? 9.696   -53.454 -48.367 1.00 84.64 ? 331 GLY   B C   1 
ATOM   5469 O O   . GLY   B 1 331 ? 10.543  -53.458 -47.469 1.00 87.42 ? 331 GLY   B O   1 
ATOM   5470 N N   . THR   B 1 332 ? 9.060   -52.352 -48.753 1.00 82.65 ? 332 THR   B N   1 
ATOM   5471 C CA  . THR   B 1 332 ? 9.262   -51.080 -48.077 1.00 78.87 ? 332 THR   B CA  1 
ATOM   5472 C C   . THR   B 1 332 ? 8.501   -51.056 -46.756 1.00 76.88 ? 332 THR   B C   1 
ATOM   5473 O O   . THR   B 1 332 ? 7.432   -51.657 -46.618 1.00 77.43 ? 332 THR   B O   1 
ATOM   5474 C CB  . THR   B 1 332 ? 8.799   -49.920 -48.961 1.00 76.96 ? 332 THR   B CB  1 
ATOM   5475 O OG1 . THR   B 1 332 ? 9.061   -50.230 -50.335 1.00 84.11 ? 332 THR   B OG1 1 
ATOM   5476 C CG2 . THR   B 1 332 ? 9.538   -48.639 -48.593 1.00 75.26 ? 332 THR   B CG2 1 
ATOM   5477 N N   . GLU   B 1 333 ? 9.066   -50.355 -45.777 1.00 73.22 ? 333 GLU   B N   1 
ATOM   5478 C CA  . GLU   B 1 333 ? 8.312   -50.219 -44.538 1.00 69.79 ? 333 GLU   B CA  1 
ATOM   5479 C C   . GLU   B 1 333 ? 7.607   -48.875 -44.513 1.00 66.00 ? 333 GLU   B C   1 
ATOM   5480 O O   . GLU   B 1 333 ? 8.236   -47.848 -44.807 1.00 63.32 ? 333 GLU   B O   1 
ATOM   5481 C CB  . GLU   B 1 333 ? 9.223   -50.348 -43.321 1.00 68.86 ? 333 GLU   B CB  1 
ATOM   5482 C CG  . GLU   B 1 333 ? 8.597   -51.152 -42.189 1.00 73.18 ? 333 GLU   B CG  1 
ATOM   5483 C CD  . GLU   B 1 333 ? 8.801   -50.519 -40.828 1.00 78.94 ? 333 GLU   B CD  1 
ATOM   5484 O OE1 . GLU   B 1 333 ? 9.553   -49.528 -40.734 1.00 82.39 ? 333 GLU   B OE1 1 
ATOM   5485 O OE2 . GLU   B 1 333 ? 8.203   -51.013 -39.850 1.00 78.83 ? 333 GLU   B OE2 1 
ATOM   5486 N N   . PRO   B 1 334 ? 6.320   -48.836 -44.184 1.00 63.96 ? 334 PRO   B N   1 
ATOM   5487 C CA  . PRO   B 1 334 ? 5.601   -47.560 -44.175 1.00 59.60 ? 334 PRO   B CA  1 
ATOM   5488 C C   . PRO   B 1 334 ? 6.080   -46.656 -43.050 1.00 57.13 ? 334 PRO   B C   1 
ATOM   5489 O O   . PRO   B 1 334 ? 6.695   -47.093 -42.075 1.00 58.32 ? 334 PRO   B O   1 
ATOM   5490 C CB  . PRO   B 1 334 ? 4.142   -47.977 -43.968 1.00 58.18 ? 334 PRO   B CB  1 
ATOM   5491 C CG  . PRO   B 1 334 ? 4.228   -49.293 -43.268 1.00 58.66 ? 334 PRO   B CG  1 
ATOM   5492 C CD  . PRO   B 1 334 ? 5.446   -49.968 -43.829 1.00 62.64 ? 334 PRO   B CD  1 
ATOM   5493 N N   . VAL   B 1 335 ? 5.791   -45.362 -43.208 1.00 55.87 ? 335 VAL   B N   1 
ATOM   5494 C CA  . VAL   B 1 335 ? 6.093   -44.405 -42.153 1.00 52.28 ? 335 VAL   B CA  1 
ATOM   5495 C C   . VAL   B 1 335 ? 5.248   -44.725 -40.930 1.00 47.49 ? 335 VAL   B C   1 
ATOM   5496 O O   . VAL   B 1 335 ? 4.018   -44.831 -41.015 1.00 48.55 ? 335 VAL   B O   1 
ATOM   5497 C CB  . VAL   B 1 335 ? 5.852   -42.972 -42.648 1.00 52.07 ? 335 VAL   B CB  1 
ATOM   5498 C CG1 . VAL   B 1 335 ? 6.093   -41.973 -41.527 1.00 47.50 ? 335 VAL   B CG1 1 
ATOM   5499 C CG2 . VAL   B 1 335 ? 6.748   -42.669 -43.843 1.00 47.56 ? 335 VAL   B CG2 1 
ATOM   5500 N N   . SER   B 1 336 ? 5.907   -44.897 -39.787 1.00 49.20 ? 336 SER   B N   1 
ATOM   5501 C CA  . SER   B 1 336 ? 5.181   -45.189 -38.563 1.00 48.37 ? 336 SER   B CA  1 
ATOM   5502 C C   . SER   B 1 336 ? 4.337   -43.987 -38.149 1.00 45.41 ? 336 SER   B C   1 
ATOM   5503 O O   . SER   B 1 336 ? 4.568   -42.851 -38.576 1.00 46.86 ? 336 SER   B O   1 
ATOM   5504 C CB  . SER   B 1 336 ? 6.144   -45.574 -37.439 1.00 46.11 ? 336 SER   B CB  1 
ATOM   5505 O OG  . SER   B 1 336 ? 6.770   -44.432 -36.881 1.00 47.70 ? 336 SER   B OG  1 
ATOM   5506 N N   . LEU   B 1 337 ? 3.332   -44.257 -37.313 1.00 45.79 ? 337 LEU   B N   1 
ATOM   5507 C CA  . LEU   B 1 337 ? 2.448   -43.191 -36.855 1.00 44.33 ? 337 LEU   B CA  1 
ATOM   5508 C C   . LEU   B 1 337 ? 3.206   -42.164 -36.026 1.00 45.96 ? 337 LEU   B C   1 
ATOM   5509 O O   . LEU   B 1 337 ? 2.948   -40.959 -36.128 1.00 44.71 ? 337 LEU   B O   1 
ATOM   5510 C CB  . LEU   B 1 337 ? 1.289   -43.780 -36.054 1.00 45.41 ? 337 LEU   B CB  1 
ATOM   5511 C CG  . LEU   B 1 337 ? 0.343   -42.768 -35.409 1.00 44.80 ? 337 LEU   B CG  1 
ATOM   5512 C CD1 . LEU   B 1 337 ? -0.250  -41.847 -36.463 1.00 42.27 ? 337 LEU   B CD1 1 
ATOM   5513 C CD2 . LEU   B 1 337 ? -0.750  -43.481 -34.639 1.00 42.87 ? 337 LEU   B CD2 1 
ATOM   5514 N N   . ASN   B 1 338 ? 4.147   -42.623 -35.198 1.00 45.67 ? 338 ASN   B N   1 
ATOM   5515 C CA  . ASN   B 1 338 ? 4.937   -41.695 -34.397 1.00 46.33 ? 338 ASN   B CA  1 
ATOM   5516 C C   . ASN   B 1 338 ? 5.775   -40.781 -35.282 1.00 42.78 ? 338 ASN   B C   1 
ATOM   5517 O O   . ASN   B 1 338 ? 5.908   -39.584 -35.002 1.00 44.63 ? 338 ASN   B O   1 
ATOM   5518 C CB  . ASN   B 1 338 ? 5.827   -42.462 -33.421 1.00 46.14 ? 338 ASN   B CB  1 
ATOM   5519 C CG  . ASN   B 1 338 ? 6.624   -41.543 -32.521 1.00 44.85 ? 338 ASN   B CG  1 
ATOM   5520 O OD1 . ASN   B 1 338 ? 7.815   -41.324 -32.737 1.00 44.36 ? 338 ASN   B OD1 1 
ATOM   5521 N ND2 . ASN   B 1 338 ? 5.963   -40.983 -31.512 1.00 45.76 ? 338 ASN   B ND2 1 
ATOM   5522 N N   . ALA   B 1 339 ? 6.343   -41.327 -36.361 1.00 44.25 ? 339 ALA   B N   1 
ATOM   5523 C CA  . ALA   B 1 339 ? 7.081   -40.496 -37.305 1.00 45.82 ? 339 ALA   B CA  1 
ATOM   5524 C C   . ALA   B 1 339 ? 6.162   -39.509 -38.012 1.00 45.64 ? 339 ALA   B C   1 
ATOM   5525 O O   . ALA   B 1 339 ? 6.585   -38.396 -38.350 1.00 45.00 ? 339 ALA   B O   1 
ATOM   5526 C CB  . ALA   B 1 339 ? 7.812   -41.378 -38.318 1.00 42.84 ? 339 ALA   B CB  1 
ATOM   5527 N N   . TRP   B 1 340 ? 4.901   -39.891 -38.233 1.00 44.11 ? 340 TRP   B N   1 
ATOM   5528 C CA  . TRP   B 1 340 ? 3.941   -38.969 -38.829 1.00 45.26 ? 340 TRP   B CA  1 
ATOM   5529 C C   . TRP   B 1 340 ? 3.647   -37.802 -37.896 1.00 45.60 ? 340 TRP   B C   1 
ATOM   5530 O O   . TRP   B 1 340 ? 3.517   -36.658 -38.343 1.00 45.35 ? 340 TRP   B O   1 
ATOM   5531 C CB  . TRP   B 1 340 ? 2.653   -39.712 -39.184 1.00 43.79 ? 340 TRP   B CB  1 
ATOM   5532 C CG  . TRP   B 1 340 ? 1.492   -38.812 -39.473 1.00 44.28 ? 340 TRP   B CG  1 
ATOM   5533 C CD1 . TRP   B 1 340 ? 0.408   -38.585 -38.671 1.00 44.02 ? 340 TRP   B CD1 1 
ATOM   5534 C CD2 . TRP   B 1 340 ? 1.299   -38.008 -40.643 1.00 46.08 ? 340 TRP   B CD2 1 
ATOM   5535 N NE1 . TRP   B 1 340 ? -0.447  -37.694 -39.273 1.00 46.42 ? 340 TRP   B NE1 1 
ATOM   5536 C CE2 . TRP   B 1 340 ? 0.077   -37.325 -40.484 1.00 45.30 ? 340 TRP   B CE2 1 
ATOM   5537 C CE3 . TRP   B 1 340 ? 2.040   -37.800 -41.809 1.00 41.63 ? 340 TRP   B CE3 1 
ATOM   5538 C CZ2 . TRP   B 1 340 ? -0.421  -36.452 -41.448 1.00 42.81 ? 340 TRP   B CZ2 1 
ATOM   5539 C CZ3 . TRP   B 1 340 ? 1.543   -36.935 -42.767 1.00 44.78 ? 340 TRP   B CZ3 1 
ATOM   5540 C CH2 . TRP   B 1 340 ? 0.323   -36.272 -42.581 1.00 43.11 ? 340 TRP   B CH2 1 
ATOM   5541 N N   . TYR   B 1 341 ? 3.542   -38.073 -36.593 1.00 45.41 ? 341 TYR   B N   1 
ATOM   5542 C CA  . TYR   B 1 341 ? 3.325   -37.001 -35.626 1.00 45.75 ? 341 TYR   B CA  1 
ATOM   5543 C C   . TYR   B 1 341 ? 4.475   -36.004 -35.645 1.00 45.96 ? 341 TYR   B C   1 
ATOM   5544 O O   . TYR   B 1 341 ? 4.258   -34.790 -35.556 1.00 47.73 ? 341 TYR   B O   1 
ATOM   5545 C CB  . TYR   B 1 341 ? 3.148   -37.588 -34.223 1.00 43.89 ? 341 TYR   B CB  1 
ATOM   5546 C CG  . TYR   B 1 341 ? 1.799   -38.226 -33.985 1.00 45.23 ? 341 TYR   B CG  1 
ATOM   5547 C CD1 . TYR   B 1 341 ? 0.632   -37.631 -34.448 1.00 47.45 ? 341 TYR   B CD1 1 
ATOM   5548 C CD2 . TYR   B 1 341 ? 1.692   -39.429 -33.299 1.00 45.82 ? 341 TYR   B CD2 1 
ATOM   5549 C CE1 . TYR   B 1 341 ? -0.604  -38.217 -34.231 1.00 44.63 ? 341 TYR   B CE1 1 
ATOM   5550 C CE2 . TYR   B 1 341 ? 0.465   -40.020 -33.078 1.00 45.52 ? 341 TYR   B CE2 1 
ATOM   5551 C CZ  . TYR   B 1 341 ? -0.679  -39.412 -33.545 1.00 44.18 ? 341 TYR   B CZ  1 
ATOM   5552 O OH  . TYR   B 1 341 ? -1.904  -39.999 -33.323 1.00 39.84 ? 341 TYR   B OH  1 
ATOM   5553 N N   . ALA   B 1 342 ? 5.709   -36.502 -35.756 1.00 45.92 ? 342 ALA   B N   1 
ATOM   5554 C CA  . ALA   B 1 342 ? 6.867   -35.619 -35.821 1.00 47.16 ? 342 ALA   B CA  1 
ATOM   5555 C C   . ALA   B 1 342 ? 6.875   -34.799 -37.103 1.00 47.44 ? 342 ALA   B C   1 
ATOM   5556 O O   . ALA   B 1 342 ? 7.325   -33.646 -37.098 1.00 46.87 ? 342 ALA   B O   1 
ATOM   5557 C CB  . ALA   B 1 342 ? 8.154   -36.435 -35.700 1.00 43.21 ? 342 ALA   B CB  1 
ATOM   5558 N N   . MET   B 1 343 ? 6.389   -35.377 -38.205 1.00 43.15 ? 343 MET   B N   1 
ATOM   5559 C CA  . MET   B 1 343 ? 6.264   -34.620 -39.446 1.00 48.02 ? 343 MET   B CA  1 
ATOM   5560 C C   . MET   B 1 343 ? 5.285   -33.460 -39.292 1.00 45.08 ? 343 MET   B C   1 
ATOM   5561 O O   . MET   B 1 343 ? 5.507   -32.370 -39.837 1.00 46.87 ? 343 MET   B O   1 
ATOM   5562 C CB  . MET   B 1 343 ? 5.822   -35.544 -40.580 1.00 47.86 ? 343 MET   B CB  1 
ATOM   5563 C CG  . MET   B 1 343 ? 6.915   -36.464 -41.098 1.00 49.98 ? 343 MET   B CG  1 
ATOM   5564 S SD  . MET   B 1 343 ? 6.300   -37.701 -42.258 1.00 53.50 ? 343 MET   B SD  1 
ATOM   5565 C CE  . MET   B 1 343 ? 5.340   -36.681 -43.374 1.00 47.34 ? 343 MET   B CE  1 
ATOM   5566 N N   . LEU   B 1 344 ? 4.193   -33.678 -38.555 1.00 45.00 ? 344 LEU   B N   1 
ATOM   5567 C CA  . LEU   B 1 344 ? 3.237   -32.602 -38.323 1.00 48.78 ? 344 LEU   B CA  1 
ATOM   5568 C C   . LEU   B 1 344 ? 3.832   -31.506 -37.450 1.00 47.10 ? 344 LEU   B C   1 
ATOM   5569 O O   . LEU   B 1 344 ? 3.473   -30.333 -37.600 1.00 47.04 ? 344 LEU   B O   1 
ATOM   5570 C CB  . LEU   B 1 344 ? 1.963   -33.158 -37.692 1.00 48.10 ? 344 LEU   B CB  1 
ATOM   5571 C CG  . LEU   B 1 344 ? 1.132   -34.058 -38.604 1.00 47.86 ? 344 LEU   B CG  1 
ATOM   5572 C CD1 . LEU   B 1 344 ? 0.014   -34.706 -37.818 1.00 49.25 ? 344 LEU   B CD1 1 
ATOM   5573 C CD2 . LEU   B 1 344 ? 0.574   -33.257 -39.772 1.00 47.83 ? 344 LEU   B CD2 1 
ATOM   5574 N N   . ASP   B 1 345 ? 4.735   -31.867 -36.538 1.00 45.40 ? 345 ASP   B N   1 
ATOM   5575 C CA  . ASP   B 1 345 ? 5.462   -30.855 -35.781 1.00 45.40 ? 345 ASP   B CA  1 
ATOM   5576 C C   . ASP   B 1 345 ? 6.420   -30.075 -36.670 1.00 46.34 ? 345 ASP   B C   1 
ATOM   5577 O O   . ASP   B 1 345 ? 6.685   -28.896 -36.409 1.00 44.55 ? 345 ASP   B O   1 
ATOM   5578 C CB  . ASP   B 1 345 ? 6.214   -31.508 -34.625 1.00 47.79 ? 345 ASP   B CB  1 
ATOM   5579 C CG  . ASP   B 1 345 ? 5.292   -31.941 -33.507 1.00 49.90 ? 345 ASP   B CG  1 
ATOM   5580 O OD1 . ASP   B 1 345 ? 4.252   -31.279 -33.313 1.00 49.36 ? 345 ASP   B OD1 1 
ATOM   5581 O OD2 . ASP   B 1 345 ? 5.604   -32.938 -32.825 1.00 50.11 ? 345 ASP   B OD2 1 
ATOM   5582 N N   . ASP   B 1 346 ? 6.948   -30.709 -37.720 1.00 46.68 ? 346 ASP   B N   1 
ATOM   5583 C CA  . ASP   B 1 346 ? 7.786   -29.985 -38.671 1.00 44.51 ? 346 ASP   B CA  1 
ATOM   5584 C C   . ASP   B 1 346 ? 6.971   -28.957 -39.444 1.00 44.34 ? 346 ASP   B C   1 
ATOM   5585 O O   . ASP   B 1 346 ? 7.452   -27.851 -39.718 1.00 44.98 ? 346 ASP   B O   1 
ATOM   5586 C CB  . ASP   B 1 346 ? 8.463   -30.964 -39.631 1.00 44.84 ? 346 ASP   B CB  1 
ATOM   5587 C CG  . ASP   B 1 346 ? 9.382   -31.943 -38.921 1.00 48.86 ? 346 ASP   B CG  1 
ATOM   5588 O OD1 . ASP   B 1 346 ? 9.918   -31.598 -37.847 1.00 49.03 ? 346 ASP   B OD1 1 
ATOM   5589 O OD2 . ASP   B 1 346 ? 9.574   -33.059 -39.447 1.00 51.39 ? 346 ASP   B OD2 1 
ATOM   5590 N N   . GLN   B 1 347 ? 5.729   -29.302 -39.794 1.00 44.07 ? 347 GLN   B N   1 
ATOM   5591 C CA  . GLN   B 1 347 ? 4.860   -28.356 -40.486 1.00 43.11 ? 347 GLN   B CA  1 
ATOM   5592 C C   . GLN   B 1 347 ? 4.485   -27.186 -39.585 1.00 43.28 ? 347 GLN   B C   1 
ATOM   5593 O O   . GLN   B 1 347 ? 4.514   -26.028 -40.018 1.00 43.38 ? 347 GLN   B O   1 
ATOM   5594 C CB  . GLN   B 1 347 ? 3.605   -29.071 -40.985 1.00 42.80 ? 347 GLN   B CB  1 
ATOM   5595 C CG  . GLN   B 1 347 ? 2.601   -28.155 -41.666 1.00 42.78 ? 347 GLN   B CG  1 
ATOM   5596 C CD  . GLN   B 1 347 ? 1.378   -28.890 -42.166 1.00 46.92 ? 347 GLN   B CD  1 
ATOM   5597 O OE1 . GLN   B 1 347 ? 0.880   -29.807 -41.517 1.00 43.13 ? 347 GLN   B OE1 1 
ATOM   5598 N NE2 . GLN   B 1 347 ? 0.886   -28.491 -43.330 1.00 42.33 ? 347 GLN   B NE2 1 
ATOM   5599 N N   . ALA   B 1 348 ? 4.119   -27.473 -38.332 1.00 45.84 ? 348 ALA   B N   1 
ATOM   5600 C CA  . ALA   B 1 348 ? 3.785   -26.409 -37.391 1.00 42.21 ? 348 ALA   B CA  1 
ATOM   5601 C C   . ALA   B 1 348 ? 4.980   -25.498 -37.144 1.00 40.67 ? 348 ALA   B C   1 
ATOM   5602 O O   . ALA   B 1 348 ? 4.820   -24.285 -36.966 1.00 41.45 ? 348 ALA   B O   1 
ATOM   5603 C CB  . ALA   B 1 348 ? 3.286   -27.012 -36.078 1.00 40.02 ? 348 ALA   B CB  1 
ATOM   5604 N N   . ARG   B 1 349 ? 6.188   -26.066 -37.128 1.00 42.11 ? 349 ARG   B N   1 
ATOM   5605 C CA  . ARG   B 1 349 ? 7.388   -25.245 -37.011 1.00 42.49 ? 349 ARG   B CA  1 
ATOM   5606 C C   . ARG   B 1 349 ? 7.545   -24.339 -38.225 1.00 46.28 ? 349 ARG   B C   1 
ATOM   5607 O O   . ARG   B 1 349 ? 7.938   -23.173 -38.097 1.00 45.55 ? 349 ARG   B O   1 
ATOM   5608 C CB  . ARG   B 1 349 ? 8.614   -26.142 -36.841 1.00 41.28 ? 349 ARG   B CB  1 
ATOM   5609 C CG  . ARG   B 1 349 ? 9.867   -25.414 -36.399 1.00 43.82 ? 349 ARG   B CG  1 
ATOM   5610 C CD  . ARG   B 1 349 ? 10.999  -26.386 -36.105 1.00 41.87 ? 349 ARG   B CD  1 
ATOM   5611 N NE  . ARG   B 1 349 ? 10.578  -27.478 -35.235 1.00 44.33 ? 349 ARG   B NE  1 
ATOM   5612 C CZ  . ARG   B 1 349 ? 10.416  -28.734 -35.630 1.00 44.52 ? 349 ARG   B CZ  1 
ATOM   5613 N NH1 . ARG   B 1 349 ? 10.650  -29.102 -36.879 1.00 43.13 ? 349 ARG   B NH1 1 
ATOM   5614 N NH2 . ARG   B 1 349 ? 10.011  -29.644 -34.749 1.00 44.34 ? 349 ARG   B NH2 1 
ATOM   5615 N N   . MET   B 1 350 ? 7.232   -24.860 -39.414 1.00 45.31 ? 350 MET   B N   1 
ATOM   5616 C CA  . MET   B 1 350 ? 7.282   -24.055 -40.629 1.00 44.25 ? 350 MET   B CA  1 
ATOM   5617 C C   . MET   B 1 350 ? 6.197   -22.985 -40.640 1.00 44.29 ? 350 MET   B C   1 
ATOM   5618 O O   . MET   B 1 350 ? 6.401   -21.902 -41.202 1.00 44.73 ? 350 MET   B O   1 
ATOM   5619 C CB  . MET   B 1 350 ? 7.147   -24.962 -41.853 1.00 45.07 ? 350 MET   B CB  1 
ATOM   5620 C CG  . MET   B 1 350 ? 7.313   -24.254 -43.176 1.00 45.64 ? 350 MET   B CG  1 
ATOM   5621 S SD  . MET   B 1 350 ? 8.975   -23.603 -43.384 1.00 49.46 ? 350 MET   B SD  1 
ATOM   5622 C CE  . MET   B 1 350 ? 9.928   -25.119 -43.383 1.00 46.11 ? 350 MET   B CE  1 
ATOM   5623 N N   . MET   B 1 351 ? 5.045   -23.264 -40.025 1.00 43.70 ? 351 MET   B N   1 
ATOM   5624 C CA  . MET   B 1 351 ? 3.965   -22.282 -39.988 1.00 42.87 ? 351 MET   B CA  1 
ATOM   5625 C C   . MET   B 1 351 ? 4.322   -21.097 -39.097 1.00 44.92 ? 351 MET   B C   1 
ATOM   5626 O O   . MET   B 1 351 ? 3.984   -19.951 -39.417 1.00 44.53 ? 351 MET   B O   1 
ATOM   5627 C CB  . MET   B 1 351 ? 2.670   -22.945 -39.515 1.00 40.04 ? 351 MET   B CB  1 
ATOM   5628 C CG  . MET   B 1 351 ? 2.105   -23.976 -40.487 1.00 44.28 ? 351 MET   B CG  1 
ATOM   5629 S SD  . MET   B 1 351 ? 0.774   -24.966 -39.777 1.00 51.58 ? 351 MET   B SD  1 
ATOM   5630 C CE  . MET   B 1 351 ? -0.362  -23.690 -39.235 1.00 42.45 ? 351 MET   B CE  1 
ATOM   5631 N N   . ARG   B 1 352 ? 4.997   -21.351 -37.972 1.00 45.61 ? 352 ARG   B N   1 
ATOM   5632 C CA  . ARG   B 1 352 ? 5.451   -20.254 -37.121 1.00 45.47 ? 352 ARG   B CA  1 
ATOM   5633 C C   . ARG   B 1 352 ? 6.511   -19.419 -37.826 1.00 47.51 ? 352 ARG   B C   1 
ATOM   5634 O O   . ARG   B 1 352 ? 6.585   -18.200 -37.630 1.00 49.47 ? 352 ARG   B O   1 
ATOM   5635 C CB  . ARG   B 1 352 ? 5.991   -20.798 -35.798 1.00 44.27 ? 352 ARG   B CB  1 
ATOM   5636 C CG  . ARG   B 1 352 ? 4.937   -21.423 -34.897 1.00 46.42 ? 352 ARG   B CG  1 
ATOM   5637 C CD  . ARG   B 1 352 ? 5.488   -21.671 -33.499 1.00 43.48 ? 352 ARG   B CD  1 
ATOM   5638 N NE  . ARG   B 1 352 ? 6.606   -22.607 -33.507 1.00 41.20 ? 352 ARG   B NE  1 
ATOM   5639 C CZ  . ARG   B 1 352 ? 6.478   -23.926 -33.480 1.00 43.63 ? 352 ARG   B CZ  1 
ATOM   5640 N NH1 . ARG   B 1 352 ? 5.289   -24.502 -33.439 1.00 44.18 ? 352 ARG   B NH1 1 
ATOM   5641 N NH2 . ARG   B 1 352 ? 7.569   -24.686 -33.498 1.00 43.76 ? 352 ARG   B NH2 1 
ATOM   5642 N N   . ALA   B 1 353 ? 7.345   -20.061 -38.648 1.00 43.42 ? 353 ALA   B N   1 
ATOM   5643 C CA  . ALA   B 1 353 ? 8.346   -19.327 -39.416 1.00 47.52 ? 353 ALA   B CA  1 
ATOM   5644 C C   . ALA   B 1 353 ? 7.691   -18.341 -40.375 1.00 49.96 ? 353 ALA   B C   1 
ATOM   5645 O O   . ALA   B 1 353 ? 8.216   -17.243 -40.604 1.00 52.16 ? 353 ALA   B O   1 
ATOM   5646 C CB  . ALA   B 1 353 ? 9.241   -20.304 -40.177 1.00 49.67 ? 353 ALA   B CB  1 
ATOM   5647 N N   . PHE   B 1 354 ? 6.545   -18.717 -40.949 1.00 45.27 ? 354 PHE   B N   1 
ATOM   5648 C CA  . PHE   B 1 354 ? 5.828   -17.794 -41.821 1.00 44.97 ? 354 PHE   B CA  1 
ATOM   5649 C C   . PHE   B 1 354 ? 5.087   -16.728 -41.026 1.00 45.35 ? 354 PHE   B C   1 
ATOM   5650 O O   . PHE   B 1 354 ? 4.881   -15.618 -41.527 1.00 44.58 ? 354 PHE   B O   1 
ATOM   5651 C CB  . PHE   B 1 354 ? 4.859   -18.563 -42.718 1.00 45.53 ? 354 PHE   B CB  1 
ATOM   5652 C CG  . PHE   B 1 354 ? 5.476   -19.054 -44.000 1.00 44.14 ? 354 PHE   B CG  1 
ATOM   5653 C CD1 . PHE   B 1 354 ? 5.680   -18.185 -45.061 1.00 46.29 ? 354 PHE   B CD1 1 
ATOM   5654 C CD2 . PHE   B 1 354 ? 5.852   -20.378 -44.144 1.00 42.06 ? 354 PHE   B CD2 1 
ATOM   5655 C CE1 . PHE   B 1 354 ? 6.249   -18.630 -46.243 1.00 43.19 ? 354 PHE   B CE1 1 
ATOM   5656 C CE2 . PHE   B 1 354 ? 6.418   -20.826 -45.317 1.00 45.27 ? 354 PHE   B CE2 1 
ATOM   5657 C CZ  . PHE   B 1 354 ? 6.619   -19.952 -46.371 1.00 42.38 ? 354 PHE   B CZ  1 
ATOM   5658 N N   . ASP   B 1 355 ? 4.673   -17.047 -39.796 1.00 48.26 ? 355 ASP   B N   1 
ATOM   5659 C CA  . ASP   B 1 355 ? 4.067   -16.042 -38.929 1.00 47.07 ? 355 ASP   B CA  1 
ATOM   5660 C C   . ASP   B 1 355 ? 5.003   -14.860 -38.725 1.00 47.61 ? 355 ASP   B C   1 
ATOM   5661 O O   . ASP   B 1 355 ? 4.579   -13.701 -38.791 1.00 50.75 ? 355 ASP   B O   1 
ATOM   5662 C CB  . ASP   B 1 355 ? 3.691   -16.661 -37.579 1.00 49.47 ? 355 ASP   B CB  1 
ATOM   5663 C CG  . ASP   B 1 355 ? 2.451   -17.524 -37.662 1.00 51.48 ? 355 ASP   B CG  1 
ATOM   5664 O OD1 . ASP   B 1 355 ? 1.588   -17.231 -38.513 1.00 50.45 ? 355 ASP   B OD1 1 
ATOM   5665 O OD2 . ASP   B 1 355 ? 2.336   -18.486 -36.876 1.00 52.77 ? 355 ASP   B OD2 1 
ATOM   5666 N N   . ARG   B 1 356 ? 6.286   -15.133 -38.486 1.00 48.04 ? 356 ARG   B N   1 
ATOM   5667 C CA  . ARG   B 1 356 ? 7.243   -14.048 -38.308 1.00 50.80 ? 356 ARG   B CA  1 
ATOM   5668 C C   . ARG   B 1 356 ? 7.513   -13.307 -39.613 1.00 50.11 ? 356 ARG   B C   1 
ATOM   5669 O O   . ARG   B 1 356 ? 7.786   -12.100 -39.590 1.00 51.09 ? 356 ARG   B O   1 
ATOM   5670 C CB  . ARG   B 1 356 ? 8.546   -14.588 -37.719 1.00 51.82 ? 356 ARG   B CB  1 
ATOM   5671 C CG  . ARG   B 1 356 ? 8.481   -14.876 -36.230 1.00 53.94 ? 356 ARG   B CG  1 
ATOM   5672 C CD  . ARG   B 1 356 ? 9.816   -15.377 -35.713 1.00 58.52 ? 356 ARG   B CD  1 
ATOM   5673 N NE  . ARG   B 1 356 ? 10.162  -16.672 -36.286 1.00 59.55 ? 356 ARG   B NE  1 
ATOM   5674 C CZ  . ARG   B 1 356 ? 9.737   -17.835 -35.814 1.00 58.46 ? 356 ARG   B CZ  1 
ATOM   5675 N NH1 . ARG   B 1 356 ? 8.941   -17.901 -34.761 1.00 53.23 ? 356 ARG   B NH1 1 
ATOM   5676 N NH2 . ARG   B 1 356 ? 10.117  -18.958 -36.416 1.00 51.40 ? 356 ARG   B NH2 1 
ATOM   5677 N N   . LEU   B 1 357 ? 7.445   -14.001 -40.754 1.00 50.61 ? 357 LEU   B N   1 
ATOM   5678 C CA  . LEU   B 1 357 ? 7.641   -13.326 -42.034 1.00 47.05 ? 357 LEU   B CA  1 
ATOM   5679 C C   . LEU   B 1 357 ? 6.538   -12.308 -42.289 1.00 48.46 ? 357 LEU   B C   1 
ATOM   5680 O O   . LEU   B 1 357 ? 6.806   -11.184 -42.729 1.00 48.61 ? 357 LEU   B O   1 
ATOM   5681 C CB  . LEU   B 1 357 ? 7.695   -14.344 -43.175 1.00 47.40 ? 357 LEU   B CB  1 
ATOM   5682 C CG  . LEU   B 1 357 ? 7.831   -13.737 -44.579 1.00 47.09 ? 357 LEU   B CG  1 
ATOM   5683 C CD1 . LEU   B 1 357 ? 9.213   -13.128 -44.776 1.00 47.86 ? 357 LEU   B CD1 1 
ATOM   5684 C CD2 . LEU   B 1 357 ? 7.522   -14.753 -45.674 1.00 51.85 ? 357 LEU   B CD2 1 
ATOM   5685 N N   . PHE   B 1 358 ? 5.290   -12.682 -42.009 1.00 47.61 ? 358 PHE   B N   1 
ATOM   5686 C CA  . PHE   B 1 358 ? 4.156   -11.794 -42.218 1.00 48.42 ? 358 PHE   B CA  1 
ATOM   5687 C C   . PHE   B 1 358 ? 4.033   -10.723 -41.144 1.00 48.60 ? 358 PHE   B C   1 
ATOM   5688 O O   . PHE   B 1 358 ? 3.090   -9.927  -41.194 1.00 51.37 ? 358 PHE   B O   1 
ATOM   5689 C CB  . PHE   B 1 358 ? 2.863   -12.607 -42.308 1.00 47.40 ? 358 PHE   B CB  1 
ATOM   5690 C CG  . PHE   B 1 358 ? 2.702   -13.332 -43.615 1.00 45.80 ? 358 PHE   B CG  1 
ATOM   5691 C CD1 . PHE   B 1 358 ? 2.501   -12.625 -44.789 1.00 44.21 ? 358 PHE   B CD1 1 
ATOM   5692 C CD2 . PHE   B 1 358 ? 2.760   -14.715 -43.674 1.00 44.13 ? 358 PHE   B CD2 1 
ATOM   5693 C CE1 . PHE   B 1 358 ? 2.357   -13.283 -46.000 1.00 45.92 ? 358 PHE   B CE1 1 
ATOM   5694 C CE2 . PHE   B 1 358 ? 2.616   -15.379 -44.880 1.00 45.90 ? 358 PHE   B CE2 1 
ATOM   5695 C CZ  . PHE   B 1 358 ? 2.414   -14.661 -46.045 1.00 45.18 ? 358 PHE   B CZ  1 
ATOM   5696 N N   . GLU   B 1 359 ? 4.950   -10.687 -40.176 1.00 46.46 ? 359 GLU   B N   1 
ATOM   5697 C CA  . GLU   B 1 359 ? 5.079   -9.521  -39.317 1.00 49.92 ? 359 GLU   B CA  1 
ATOM   5698 C C   . GLU   B 1 359 ? 5.813   -8.385  -40.013 1.00 51.49 ? 359 GLU   B C   1 
ATOM   5699 O O   . GLU   B 1 359 ? 5.673   -7.227  -39.603 1.00 53.63 ? 359 GLU   B O   1 
ATOM   5700 C CB  . GLU   B 1 359 ? 5.806   -9.891  -38.023 1.00 50.87 ? 359 GLU   B CB  1 
ATOM   5701 C CG  . GLU   B 1 359 ? 5.000   -10.769 -37.084 1.00 51.43 ? 359 GLU   B CG  1 
ATOM   5702 C CD  . GLU   B 1 359 ? 5.769   -11.130 -35.831 1.00 56.67 ? 359 GLU   B CD  1 
ATOM   5703 O OE1 . GLU   B 1 359 ? 7.014   -11.058 -35.856 1.00 58.04 ? 359 GLU   B OE1 1 
ATOM   5704 O OE2 . GLU   B 1 359 ? 5.127   -11.482 -34.820 1.00 59.72 ? 359 GLU   B OE2 1 
ATOM   5705 N N   . SER   B 1 360 ? 6.586   -8.696  -41.056 1.00 51.90 ? 360 SER   B N   1 
ATOM   5706 C CA  . SER   B 1 360 ? 7.302   -7.697  -41.835 1.00 50.79 ? 360 SER   B CA  1 
ATOM   5707 C C   . SER   B 1 360 ? 6.658   -7.412  -43.185 1.00 50.09 ? 360 SER   B C   1 
ATOM   5708 O O   . SER   B 1 360 ? 6.951   -6.371  -43.783 1.00 47.41 ? 360 SER   B O   1 
ATOM   5709 C CB  . SER   B 1 360 ? 8.753   -8.141  -42.062 1.00 53.46 ? 360 SER   B CB  1 
ATOM   5710 O OG  . SER   B 1 360 ? 9.395   -8.462  -40.841 1.00 56.10 ? 360 SER   B OG  1 
ATOM   5711 N N   . PHE   B 1 361 ? 5.800   -8.301  -43.679 1.00 50.42 ? 361 PHE   B N   1 
ATOM   5712 C CA  . PHE   B 1 361 ? 5.193   -8.149  -44.992 1.00 47.22 ? 361 PHE   B CA  1 
ATOM   5713 C C   . PHE   B 1 361 ? 3.700   -8.431  -44.926 1.00 48.03 ? 361 PHE   B C   1 
ATOM   5714 O O   . PHE   B 1 361 ? 3.231   -9.208  -44.090 1.00 48.54 ? 361 PHE   B O   1 
ATOM   5715 C CB  . PHE   B 1 361 ? 5.835   -9.083  -46.023 1.00 45.79 ? 361 PHE   B CB  1 
ATOM   5716 C CG  . PHE   B 1 361 ? 7.309   -8.879  -46.186 1.00 47.65 ? 361 PHE   B CG  1 
ATOM   5717 C CD1 . PHE   B 1 361 ? 7.799   -7.853  -46.980 1.00 44.87 ? 361 PHE   B CD1 1 
ATOM   5718 C CD2 . PHE   B 1 361 ? 8.208   -9.721  -45.557 1.00 47.57 ? 361 PHE   B CD2 1 
ATOM   5719 C CE1 . PHE   B 1 361 ? 9.161   -7.667  -47.132 1.00 43.33 ? 361 PHE   B CE1 1 
ATOM   5720 C CE2 . PHE   B 1 361 ? 9.567   -9.541  -45.706 1.00 48.41 ? 361 PHE   B CE2 1 
ATOM   5721 C CZ  . PHE   B 1 361 ? 10.045  -8.511  -46.492 1.00 46.86 ? 361 PHE   B CZ  1 
ATOM   5722 N N   . ASP   B 1 362 ? 2.961   -7.791  -45.830 1.00 45.91 ? 362 ASP   B N   1 
ATOM   5723 C CA  . ASP   B 1 362 ? 1.542   -8.065  -45.997 1.00 45.57 ? 362 ASP   B CA  1 
ATOM   5724 C C   . ASP   B 1 362 ? 1.270   -9.162  -47.015 1.00 42.90 ? 362 ASP   B C   1 
ATOM   5725 O O   . ASP   B 1 362 ? 0.239   -9.837  -46.918 1.00 41.34 ? 362 ASP   B O   1 
ATOM   5726 C CB  . ASP   B 1 362 ? 0.806   -6.794  -46.429 1.00 45.90 ? 362 ASP   B CB  1 
ATOM   5727 C CG  . ASP   B 1 362 ? 0.923   -5.678  -45.413 1.00 48.85 ? 362 ASP   B CG  1 
ATOM   5728 O OD1 . ASP   B 1 362 ? 0.361   -5.819  -44.307 1.00 50.55 ? 362 ASP   B OD1 1 
ATOM   5729 O OD2 . ASP   B 1 362 ? 1.589   -4.664  -45.715 1.00 49.91 ? 362 ASP   B OD2 1 
ATOM   5730 N N   . ALA   B 1 363 ? 2.161   -9.357  -47.984 1.00 42.07 ? 363 ALA   B N   1 
ATOM   5731 C CA  . ALA   B 1 363 ? 1.895   -10.295 -49.063 1.00 42.72 ? 363 ALA   B CA  1 
ATOM   5732 C C   . ALA   B 1 363 ? 3.197   -10.687 -49.742 1.00 38.90 ? 363 ALA   B C   1 
ATOM   5733 O O   . ALA   B 1 363 ? 4.145   -9.899  -49.798 1.00 39.03 ? 363 ALA   B O   1 
ATOM   5734 C CB  . ALA   B 1 363 ? 0.927   -9.702  -50.094 1.00 37.76 ? 363 ALA   B CB  1 
ATOM   5735 N N   . ILE   B 1 364 ? 3.225   -11.916 -50.256 1.00 39.24 ? 364 ILE   B N   1 
ATOM   5736 C CA  . ILE   B 1 364 ? 4.292   -12.398 -51.125 1.00 43.11 ? 364 ILE   B CA  1 
ATOM   5737 C C   . ILE   B 1 364 ? 3.786   -12.369 -52.560 1.00 43.62 ? 364 ILE   B C   1 
ATOM   5738 O O   . ILE   B 1 364 ? 2.670   -12.823 -52.841 1.00 43.68 ? 364 ILE   B O   1 
ATOM   5739 C CB  . ILE   B 1 364 ? 4.738   -13.820 -50.738 1.00 43.28 ? 364 ILE   B CB  1 
ATOM   5740 C CG1 . ILE   B 1 364 ? 5.287   -13.859 -49.311 1.00 39.90 ? 364 ILE   B CG1 1 
ATOM   5741 C CG2 . ILE   B 1 364 ? 5.775   -14.349 -51.721 1.00 40.80 ? 364 ILE   B CG2 1 
ATOM   5742 C CD1 . ILE   B 1 364 ? 5.694   -15.250 -48.858 1.00 44.34 ? 364 ILE   B CD1 1 
ATOM   5743 N N   . PHE   B 1 365 ? 4.594   -11.830 -53.467 1.00 43.73 ? 365 PHE   B N   1 
ATOM   5744 C CA  . PHE   B 1 365 ? 4.310   -11.869 -54.895 1.00 41.66 ? 365 PHE   B CA  1 
ATOM   5745 C C   . PHE   B 1 365 ? 5.287   -12.832 -55.553 1.00 42.89 ? 365 PHE   B C   1 
ATOM   5746 O O   . PHE   B 1 365 ? 6.506   -12.679 -55.410 1.00 45.81 ? 365 PHE   B O   1 
ATOM   5747 C CB  . PHE   B 1 365 ? 4.419   -10.480 -55.534 1.00 44.74 ? 365 PHE   B CB  1 
ATOM   5748 C CG  . PHE   B 1 365 ? 3.246   -9.574  -55.249 1.00 45.29 ? 365 PHE   B CG  1 
ATOM   5749 C CD1 . PHE   B 1 365 ? 2.459   -9.755  -54.122 1.00 43.98 ? 365 PHE   B CD1 1 
ATOM   5750 C CD2 . PHE   B 1 365 ? 2.930   -8.540  -56.117 1.00 43.48 ? 365 PHE   B CD2 1 
ATOM   5751 C CE1 . PHE   B 1 365 ? 1.389   -8.920  -53.859 1.00 43.35 ? 365 PHE   B CE1 1 
ATOM   5752 C CE2 . PHE   B 1 365 ? 1.855   -7.702  -55.863 1.00 44.62 ? 365 PHE   B CE2 1 
ATOM   5753 C CZ  . PHE   B 1 365 ? 1.085   -7.893  -54.731 1.00 46.92 ? 365 PHE   B CZ  1 
ATOM   5754 N N   . CYS   B 1 366 ? 4.755   -13.820 -56.264 1.00 43.39 ? 366 CYS   B N   1 
ATOM   5755 C CA  . CYS   B 1 366 ? 5.579   -14.866 -56.855 1.00 43.40 ? 366 CYS   B CA  1 
ATOM   5756 C C   . CYS   B 1 366 ? 4.787   -15.511 -57.981 1.00 43.67 ? 366 CYS   B C   1 
ATOM   5757 O O   . CYS   B 1 366 ? 3.567   -15.319 -58.080 1.00 44.28 ? 366 CYS   B O   1 
ATOM   5758 C CB  . CYS   B 1 366 ? 5.999   -15.908 -55.800 1.00 43.62 ? 366 CYS   B CB  1 
ATOM   5759 S SG  . CYS   B 1 366 ? 4.656   -16.941 -55.175 1.00 41.79 ? 366 CYS   B SG  1 
ATOM   5760 N N   . PRO   B 1 367 ? 5.448   -16.264 -58.861 1.00 40.79 ? 367 PRO   B N   1 
ATOM   5761 C CA  . PRO   B 1 367 ? 4.707   -16.977 -59.906 1.00 44.43 ? 367 PRO   B CA  1 
ATOM   5762 C C   . PRO   B 1 367 ? 3.818   -18.066 -59.328 1.00 43.09 ? 367 PRO   B C   1 
ATOM   5763 O O   . PRO   B 1 367 ? 4.071   -18.608 -58.248 1.00 40.89 ? 367 PRO   B O   1 
ATOM   5764 C CB  . PRO   B 1 367 ? 5.814   -17.581 -60.781 1.00 45.89 ? 367 PRO   B CB  1 
ATOM   5765 C CG  . PRO   B 1 367 ? 7.024   -16.758 -60.502 1.00 48.12 ? 367 PRO   B CG  1 
ATOM   5766 C CD  . PRO   B 1 367 ? 6.906   -16.360 -59.063 1.00 39.51 ? 367 PRO   B CD  1 
ATOM   5767 N N   . VAL   B 1 368 ? 2.751   -18.374 -60.065 1.00 41.85 ? 368 VAL   B N   1 
ATOM   5768 C CA  . VAL   B 1 368 ? 1.988   -19.586 -59.789 1.00 42.51 ? 368 VAL   B CA  1 
ATOM   5769 C C   . VAL   B 1 368 ? 2.785   -20.809 -60.223 1.00 43.89 ? 368 VAL   B C   1 
ATOM   5770 O O   . VAL   B 1 368 ? 2.984   -21.752 -59.450 1.00 42.82 ? 368 VAL   B O   1 
ATOM   5771 C CB  . VAL   B 1 368 ? 0.618   -19.532 -60.486 1.00 38.70 ? 368 VAL   B CB  1 
ATOM   5772 C CG1 . VAL   B 1 368 ? -0.138  -20.830 -60.260 1.00 39.85 ? 368 VAL   B CG1 1 
ATOM   5773 C CG2 . VAL   B 1 368 ? -0.183  -18.338 -59.992 1.00 38.78 ? 368 VAL   B CG2 1 
ATOM   5774 N N   . LEU   B 1 369 ? 3.260   -20.801 -61.466 1.00 42.99 ? 369 LEU   B N   1 
ATOM   5775 C CA  . LEU   B 1 369 ? 4.153   -21.825 -61.980 1.00 43.06 ? 369 LEU   B CA  1 
ATOM   5776 C C   . LEU   B 1 369 ? 5.232   -21.141 -62.807 1.00 45.25 ? 369 LEU   B C   1 
ATOM   5777 O O   . LEU   B 1 369 ? 5.101   -19.977 -63.194 1.00 44.27 ? 369 LEU   B O   1 
ATOM   5778 C CB  . LEU   B 1 369 ? 3.398   -22.870 -62.815 1.00 43.61 ? 369 LEU   B CB  1 
ATOM   5779 C CG  . LEU   B 1 369 ? 3.589   -24.338 -62.420 1.00 45.06 ? 369 LEU   B CG  1 
ATOM   5780 C CD1 . LEU   B 1 369 ? 3.213   -24.570 -60.963 1.00 43.70 ? 369 LEU   B CD1 1 
ATOM   5781 C CD2 . LEU   B 1 369 ? 2.785   -25.253 -63.332 1.00 41.19 ? 369 LEU   B CD2 1 
ATOM   5782 N N   . GLY   B 1 370 ? 6.311   -21.878 -63.074 1.00 44.05 ? 370 GLY   B N   1 
ATOM   5783 C CA  . GLY   B 1 370 ? 7.440   -21.306 -63.785 1.00 46.88 ? 370 GLY   B CA  1 
ATOM   5784 C C   . GLY   B 1 370 ? 7.159   -20.961 -65.232 1.00 49.35 ? 370 GLY   B C   1 
ATOM   5785 O O   . GLY   B 1 370 ? 7.865   -20.126 -65.806 1.00 49.71 ? 370 GLY   B O   1 
ATOM   5786 N N   . THR   B 1 371 ? 6.147   -21.579 -65.836 1.00 47.79 ? 371 THR   B N   1 
ATOM   5787 C CA  . THR   B 1 371 ? 5.837   -21.347 -67.237 1.00 49.16 ? 371 THR   B CA  1 
ATOM   5788 C C   . THR   B 1 371 ? 4.327   -21.386 -67.424 1.00 46.96 ? 371 THR   B C   1 
ATOM   5789 O O   . THR   B 1 371 ? 3.565   -21.594 -66.475 1.00 44.90 ? 371 THR   B O   1 
ATOM   5790 C CB  . THR   B 1 371 ? 6.534   -22.374 -68.140 1.00 51.74 ? 371 THR   B CB  1 
ATOM   5791 O OG1 . THR   B 1 371 ? 6.443   -21.950 -69.507 1.00 55.25 ? 371 THR   B OG1 1 
ATOM   5792 C CG2 . THR   B 1 371 ? 5.884   -23.742 -67.994 1.00 50.46 ? 371 THR   B CG2 1 
ATOM   5793 N N   . THR   B 1 372 ? 3.896   -21.182 -68.665 1.00 47.73 ? 372 THR   B N   1 
ATOM   5794 C CA  . THR   B 1 372 ? 2.483   -21.169 -68.999 1.00 45.55 ? 372 THR   B CA  1 
ATOM   5795 C C   . THR   B 1 372 ? 2.005   -22.576 -69.360 1.00 43.44 ? 372 THR   B C   1 
ATOM   5796 O O   . THR   B 1 372 ? 2.733   -23.564 -69.230 1.00 42.74 ? 372 THR   B O   1 
ATOM   5797 C CB  . THR   B 1 372 ? 2.217   -20.185 -70.137 1.00 45.66 ? 372 THR   B CB  1 
ATOM   5798 O OG1 . THR   B 1 372 ? 3.132   -20.434 -71.213 1.00 47.34 ? 372 THR   B OG1 1 
ATOM   5799 C CG2 . THR   B 1 372 ? 2.392   -18.757 -69.648 1.00 43.72 ? 372 THR   B CG2 1 
ATOM   5800 N N   . ALA   B 1 373 ? 0.761   -22.661 -69.830 1.00 43.56 ? 373 ALA   B N   1 
ATOM   5801 C CA  . ALA   B 1 373 ? 0.141   -23.950 -70.112 1.00 44.17 ? 373 ALA   B CA  1 
ATOM   5802 C C   . ALA   B 1 373 ? 0.932   -24.717 -71.163 1.00 49.02 ? 373 ALA   B C   1 
ATOM   5803 O O   . ALA   B 1 373 ? 1.216   -24.200 -72.247 1.00 46.51 ? 373 ALA   B O   1 
ATOM   5804 C CB  . ALA   B 1 373 ? -1.299  -23.747 -70.576 1.00 42.91 ? 373 ALA   B CB  1 
ATOM   5805 N N   . PHE   B 1 374 ? 1.285   -25.953 -70.833 1.00 48.52 ? 374 PHE   B N   1 
ATOM   5806 C CA  . PHE   B 1 374 ? 2.080   -26.805 -71.700 1.00 49.88 ? 374 PHE   B CA  1 
ATOM   5807 C C   . PHE   B 1 374 ? 1.179   -27.654 -72.597 1.00 49.57 ? 374 PHE   B C   1 
ATOM   5808 O O   . PHE   B 1 374 ? -0.019  -27.808 -72.358 1.00 50.26 ? 374 PHE   B O   1 
ATOM   5809 C CB  . PHE   B 1 374 ? 3.002   -27.692 -70.859 1.00 48.69 ? 374 PHE   B CB  1 
ATOM   5810 C CG  . PHE   B 1 374 ? 2.284   -28.482 -69.794 1.00 46.42 ? 374 PHE   B CG  1 
ATOM   5811 C CD1 . PHE   B 1 374 ? 2.092   -27.955 -68.525 1.00 48.32 ? 374 PHE   B CD1 1 
ATOM   5812 C CD2 . PHE   B 1 374 ? 1.809   -29.754 -70.063 1.00 46.14 ? 374 PHE   B CD2 1 
ATOM   5813 C CE1 . PHE   B 1 374 ? 1.435   -28.682 -67.549 1.00 47.41 ? 374 PHE   B CE1 1 
ATOM   5814 C CE2 . PHE   B 1 374 ? 1.152   -30.486 -69.092 1.00 45.32 ? 374 PHE   B CE2 1 
ATOM   5815 C CZ  . PHE   B 1 374 ? 0.963   -29.950 -67.833 1.00 50.14 ? 374 PHE   B CZ  1 
ATOM   5816 N N   . ALA   B 1 375 ? 1.779   -28.211 -73.644 1.00 47.31 ? 375 ALA   B N   1 
ATOM   5817 C CA  . ALA   B 1 375 ? 1.052   -29.087 -74.551 1.00 49.69 ? 375 ALA   B CA  1 
ATOM   5818 C C   . ALA   B 1 375 ? 0.640   -30.374 -73.843 1.00 43.86 ? 375 ALA   B C   1 
ATOM   5819 O O   . ALA   B 1 375 ? 1.303   -30.836 -72.910 1.00 46.25 ? 375 ALA   B O   1 
ATOM   5820 C CB  . ALA   B 1 375 ? 1.908   -29.417 -75.775 1.00 46.19 ? 375 ALA   B CB  1 
ATOM   5821 N N   . HIS   B 1 376 ? -0.472  -30.950 -74.300 1.00 44.70 ? 376 HIS   B N   1 
ATOM   5822 C CA  . HIS   B 1 376 ? -1.006  -32.175 -73.715 1.00 46.49 ? 376 HIS   B CA  1 
ATOM   5823 C C   . HIS   B 1 376 ? 0.050   -33.272 -73.685 1.00 47.26 ? 376 HIS   B C   1 
ATOM   5824 O O   . HIS   B 1 376 ? 0.605   -33.644 -74.723 1.00 50.71 ? 376 HIS   B O   1 
ATOM   5825 C CB  . HIS   B 1 376 ? -2.226  -32.643 -74.511 1.00 45.39 ? 376 HIS   B CB  1 
ATOM   5826 C CG  . HIS   B 1 376 ? -3.267  -31.585 -74.709 1.00 45.73 ? 376 HIS   B CG  1 
ATOM   5827 N ND1 . HIS   B 1 376 ? -4.020  -31.078 -73.672 1.00 43.62 ? 376 HIS   B ND1 1 
ATOM   5828 C CD2 . HIS   B 1 376 ? -3.695  -30.953 -75.828 1.00 44.37 ? 376 HIS   B CD2 1 
ATOM   5829 C CE1 . HIS   B 1 376 ? -4.860  -30.172 -74.142 1.00 44.30 ? 376 HIS   B CE1 1 
ATOM   5830 N NE2 . HIS   B 1 376 ? -4.681  -30.077 -75.448 1.00 44.99 ? 376 HIS   B NE2 1 
ATOM   5831 N N   . SER   B 1 377 ? 0.321   -33.791 -72.490 1.00 47.68 ? 377 SER   B N   1 
ATOM   5832 C CA  . SER   B 1 377 ? 1.344   -34.805 -72.280 1.00 51.23 ? 377 SER   B CA  1 
ATOM   5833 C C   . SER   B 1 377 ? 0.692   -36.166 -72.074 1.00 54.52 ? 377 SER   B C   1 
ATOM   5834 O O   . SER   B 1 377 ? -0.286  -36.290 -71.330 1.00 51.60 ? 377 SER   B O   1 
ATOM   5835 C CB  . SER   B 1 377 ? 2.225   -34.456 -71.078 1.00 51.12 ? 377 SER   B CB  1 
ATOM   5836 O OG  . SER   B 1 377 ? 3.299   -35.372 -70.945 1.00 55.85 ? 377 SER   B OG  1 
ATOM   5837 N N   . ASP   B 1 378 ? 1.241   -37.183 -72.739 1.00 59.59 ? 378 ASP   B N   1 
ATOM   5838 C CA  . ASP   B 1 378 ? 0.721   -38.541 -72.652 1.00 56.86 ? 378 ASP   B CA  1 
ATOM   5839 C C   . ASP   B 1 378 ? 1.320   -39.336 -71.501 1.00 54.62 ? 378 ASP   B C   1 
ATOM   5840 O O   . ASP   B 1 378 ? 0.770   -40.383 -71.137 1.00 56.70 ? 378 ASP   B O   1 
ATOM   5841 C CB  . ASP   B 1 378 ? 0.991   -39.290 -73.963 1.00 59.30 ? 378 ASP   B CB  1 
ATOM   5842 C CG  . ASP   B 1 378 ? -0.251  -39.949 -74.533 1.00 63.78 ? 378 ASP   B CG  1 
ATOM   5843 O OD1 . ASP   B 1 378 ? -1.370  -39.561 -74.138 1.00 67.87 ? 378 ASP   B OD1 1 
ATOM   5844 O OD2 . ASP   B 1 378 ? -0.106  -40.854 -75.383 1.00 62.71 ? 378 ASP   B OD2 1 
ATOM   5845 N N   . GLU   B 1 379 ? 2.422   -38.865 -70.919 1.00 55.23 ? 379 GLU   B N   1 
ATOM   5846 C CA  . GLU   B 1 379 ? 3.187   -39.656 -69.964 1.00 58.45 ? 379 GLU   B CA  1 
ATOM   5847 C C   . GLU   B 1 379 ? 2.634   -39.475 -68.557 1.00 56.71 ? 379 GLU   B C   1 
ATOM   5848 O O   . GLU   B 1 379 ? 2.656   -38.353 -68.035 1.00 52.90 ? 379 GLU   B O   1 
ATOM   5849 C CB  . GLU   B 1 379 ? 4.653   -39.262 -69.999 1.00 57.66 ? 379 GLU   B CB  1 
ATOM   5850 C CG  . GLU   B 1 379 ? 5.503   -39.988 -68.973 1.00 57.82 ? 379 GLU   B CG  1 
ATOM   5851 C CD  . GLU   B 1 379 ? 5.360   -41.496 -69.062 1.00 59.76 ? 379 GLU   B CD  1 
ATOM   5852 O OE1 . GLU   B 1 379 ? 5.400   -42.037 -70.188 1.00 63.07 ? 379 GLU   B OE1 1 
ATOM   5853 O OE2 . GLU   B 1 379 ? 5.197   -42.140 -68.005 1.00 59.29 ? 379 GLU   B OE2 1 
ATOM   5854 N N   . PRO   B 1 380 ? 2.145   -40.536 -67.907 1.00 59.46 ? 380 PRO   B N   1 
ATOM   5855 C CA  . PRO   B 1 380 ? 1.624   -40.377 -66.540 1.00 55.82 ? 380 PRO   B CA  1 
ATOM   5856 C C   . PRO   B 1 380 ? 2.704   -40.136 -65.497 1.00 56.60 ? 380 PRO   B C   1 
ATOM   5857 O O   . PRO   B 1 380 ? 2.417   -39.517 -64.464 1.00 54.91 ? 380 PRO   B O   1 
ATOM   5858 C CB  . PRO   B 1 380 ? 0.884   -41.700 -66.292 1.00 54.84 ? 380 PRO   B CB  1 
ATOM   5859 C CG  . PRO   B 1 380 ? 1.547   -42.681 -67.206 1.00 56.95 ? 380 PRO   B CG  1 
ATOM   5860 C CD  . PRO   B 1 380 ? 1.942   -41.900 -68.429 1.00 57.16 ? 380 PRO   B CD  1 
ATOM   5861 N N   . ASP   B 1 381 ? 3.932   -40.599 -65.726 1.00 59.07 ? 381 ASP   B N   1 
ATOM   5862 C CA  . ASP   B 1 381 ? 5.013   -40.416 -64.761 1.00 55.35 ? 381 ASP   B CA  1 
ATOM   5863 C C   . ASP   B 1 381 ? 5.586   -39.012 -64.914 1.00 55.67 ? 381 ASP   B C   1 
ATOM   5864 O O   . ASP   B 1 381 ? 6.136   -38.669 -65.966 1.00 57.62 ? 381 ASP   B O   1 
ATOM   5865 C CB  . ASP   B 1 381 ? 6.092   -41.478 -64.960 1.00 56.63 ? 381 ASP   B CB  1 
ATOM   5866 C CG  . ASP   B 1 381 ? 7.226   -41.361 -63.953 1.00 57.21 ? 381 ASP   B CG  1 
ATOM   5867 O OD1 . ASP   B 1 381 ? 7.062   -40.656 -62.934 1.00 60.66 ? 381 ASP   B OD1 1 
ATOM   5868 O OD2 . ASP   B 1 381 ? 8.290   -41.972 -64.188 1.00 57.72 ? 381 ASP   B OD2 1 
ATOM   5869 N N   . TRP   B 1 382 ? 5.457   -38.200 -63.860 1.00 54.72 ? 382 TRP   B N   1 
ATOM   5870 C CA  . TRP   B 1 382 ? 6.014   -36.851 -63.886 1.00 53.25 ? 382 TRP   B CA  1 
ATOM   5871 C C   . TRP   B 1 382 ? 7.526   -36.869 -64.075 1.00 50.52 ? 382 TRP   B C   1 
ATOM   5872 O O   . TRP   B 1 382 ? 8.089   -35.937 -64.660 1.00 51.29 ? 382 TRP   B O   1 
ATOM   5873 C CB  . TRP   B 1 382 ? 5.658   -36.108 -62.598 1.00 54.84 ? 382 TRP   B CB  1 
ATOM   5874 C CG  . TRP   B 1 382 ? 4.327   -35.417 -62.622 1.00 52.58 ? 382 TRP   B CG  1 
ATOM   5875 C CD1 . TRP   B 1 382 ? 3.229   -35.762 -63.359 1.00 51.72 ? 382 TRP   B CD1 1 
ATOM   5876 C CD2 . TRP   B 1 382 ? 3.959   -34.248 -61.877 1.00 50.31 ? 382 TRP   B CD2 1 
ATOM   5877 N NE1 . TRP   B 1 382 ? 2.199   -34.884 -63.110 1.00 50.75 ? 382 TRP   B NE1 1 
ATOM   5878 C CE2 . TRP   B 1 382 ? 2.623   -33.944 -62.209 1.00 51.35 ? 382 TRP   B CE2 1 
ATOM   5879 C CE3 . TRP   B 1 382 ? 4.630   -33.432 -60.962 1.00 49.16 ? 382 TRP   B CE3 1 
ATOM   5880 C CZ2 . TRP   B 1 382 ? 1.946   -32.856 -61.658 1.00 49.39 ? 382 TRP   B CZ2 1 
ATOM   5881 C CZ3 . TRP   B 1 382 ? 3.956   -32.355 -60.412 1.00 49.20 ? 382 TRP   B CZ3 1 
ATOM   5882 C CH2 . TRP   B 1 382 ? 2.628   -32.077 -60.761 1.00 46.75 ? 382 TRP   B CH2 1 
ATOM   5883 N N   . ALA   B 1 383 ? 8.197   -37.917 -63.589 1.00 54.35 ? 383 ALA   B N   1 
ATOM   5884 C CA  . ALA   B 1 383 ? 9.648   -38.007 -63.705 1.00 57.25 ? 383 ALA   B CA  1 
ATOM   5885 C C   . ALA   B 1 383 ? 10.116  -38.112 -65.150 1.00 55.78 ? 383 ALA   B C   1 
ATOM   5886 O O   . ALA   B 1 383 ? 11.271  -37.782 -65.438 1.00 56.14 ? 383 ALA   B O   1 
ATOM   5887 C CB  . ALA   B 1 383 ? 10.163  -39.204 -62.906 1.00 53.07 ? 383 ALA   B CB  1 
ATOM   5888 N N   . LYS   B 1 384 ? 9.254   -38.558 -66.063 1.00 56.53 ? 384 LYS   B N   1 
ATOM   5889 C CA  . LYS   B 1 384 ? 9.604   -38.679 -67.471 1.00 55.39 ? 384 LYS   B CA  1 
ATOM   5890 C C   . LYS   B 1 384 ? 9.180   -37.468 -68.292 1.00 57.76 ? 384 LYS   B C   1 
ATOM   5891 O O   . LYS   B 1 384 ? 9.342   -37.477 -69.517 1.00 57.87 ? 384 LYS   B O   1 
ATOM   5892 C CB  . LYS   B 1 384 ? 8.986   -39.947 -68.066 1.00 55.58 ? 384 LYS   B CB  1 
ATOM   5893 C CG  . LYS   B 1 384 ? 9.399   -41.241 -67.383 1.00 57.13 ? 384 LYS   B CG  1 
ATOM   5894 C CD  . LYS   B 1 384 ? 8.959   -42.444 -68.203 1.00 61.07 ? 384 LYS   B CD  1 
ATOM   5895 C CE  . LYS   B 1 384 ? 9.332   -43.755 -67.531 1.00 61.32 ? 384 LYS   B CE  1 
ATOM   5896 N NZ  . LYS   B 1 384 ? 8.453   -44.060 -66.370 1.00 62.16 ? 384 LYS   B NZ  1 
ATOM   5897 N N   . ARG   B 1 385 ? 8.640   -36.435 -67.656 1.00 55.13 ? 385 ARG   B N   1 
ATOM   5898 C CA  . ARG   B 1 385 ? 8.191   -35.238 -68.351 1.00 56.91 ? 385 ARG   B CA  1 
ATOM   5899 C C   . ARG   B 1 385 ? 9.255   -34.148 -68.295 1.00 53.48 ? 385 ARG   B C   1 
ATOM   5900 O O   . ARG   B 1 385 ? 10.160  -34.168 -67.458 1.00 55.58 ? 385 ARG   B O   1 
ATOM   5901 C CB  . ARG   B 1 385 ? 6.883   -34.713 -67.752 1.00 53.35 ? 385 ARG   B CB  1 
ATOM   5902 C CG  . ARG   B 1 385 ? 5.691   -35.638 -67.911 1.00 53.12 ? 385 ARG   B CG  1 
ATOM   5903 C CD  . ARG   B 1 385 ? 4.414   -34.948 -67.453 1.00 52.83 ? 385 ARG   B CD  1 
ATOM   5904 N NE  . ARG   B 1 385 ? 3.274   -35.856 -67.422 1.00 53.54 ? 385 ARG   B NE  1 
ATOM   5905 C CZ  . ARG   B 1 385 ? 2.051   -35.513 -67.042 1.00 52.41 ? 385 ARG   B CZ  1 
ATOM   5906 N NH1 . ARG   B 1 385 ? 1.767   -34.279 -66.660 1.00 51.04 ? 385 ARG   B NH1 1 
ATOM   5907 N NH2 . ARG   B 1 385 ? 1.090   -36.432 -67.043 1.00 50.17 ? 385 ARG   B NH2 1 
ATOM   5908 N N   . SER   B 1 386 ? 9.124   -33.185 -69.203 1.00 56.27 ? 386 SER   B N   1 
ATOM   5909 C CA  . SER   B 1 386 ? 10.022  -32.043 -69.266 1.00 55.98 ? 386 SER   B CA  1 
ATOM   5910 C C   . SER   B 1 386 ? 9.215   -30.797 -69.598 1.00 55.67 ? 386 SER   B C   1 
ATOM   5911 O O   . SER   B 1 386 ? 8.078   -30.877 -70.067 1.00 56.50 ? 386 SER   B O   1 
ATOM   5912 C CB  . SER   B 1 386 ? 11.133  -32.248 -70.305 1.00 55.58 ? 386 SER   B CB  1 
ATOM   5913 O OG  . SER   B 1 386 ? 10.610  -32.238 -71.623 1.00 61.81 ? 386 SER   B OG  1 
ATOM   5914 N N   . LEU   B 1 387 ? 9.821   -29.639 -69.347 1.00 57.08 ? 387 LEU   B N   1 
ATOM   5915 C CA  . LEU   B 1 387 ? 9.196   -28.354 -69.624 1.00 57.28 ? 387 LEU   B CA  1 
ATOM   5916 C C   . LEU   B 1 387 ? 10.128  -27.496 -70.464 1.00 58.99 ? 387 LEU   B C   1 
ATOM   5917 O O   . LEU   B 1 387 ? 11.345  -27.493 -70.255 1.00 60.44 ? 387 LEU   B O   1 
ATOM   5918 C CB  . LEU   B 1 387 ? 8.832   -27.613 -68.329 1.00 57.36 ? 387 LEU   B CB  1 
ATOM   5919 C CG  . LEU   B 1 387 ? 7.652   -28.165 -67.530 1.00 54.27 ? 387 LEU   B CG  1 
ATOM   5920 C CD1 . LEU   B 1 387 ? 7.387   -27.303 -66.310 1.00 49.58 ? 387 LEU   B CD1 1 
ATOM   5921 C CD2 . LEU   B 1 387 ? 6.415   -28.251 -68.403 1.00 53.50 ? 387 LEU   B CD2 1 
ATOM   5922 N N   . SER   B 1 388 ? 9.548   -26.775 -71.420 1.00 58.84 ? 388 SER   B N   1 
ATOM   5923 C CA  . SER   B 1 388 ? 10.289  -25.830 -72.247 1.00 61.34 ? 388 SER   B CA  1 
ATOM   5924 C C   . SER   B 1 388 ? 10.312  -24.484 -71.533 1.00 61.38 ? 388 SER   B C   1 
ATOM   5925 O O   . SER   B 1 388 ? 9.302   -23.775 -71.498 1.00 58.97 ? 388 SER   B O   1 
ATOM   5926 C CB  . SER   B 1 388 ? 9.655   -25.711 -73.631 1.00 60.18 ? 388 SER   B CB  1 
ATOM   5927 O OG  . SER   B 1 388 ? 10.303  -24.718 -74.407 1.00 66.88 ? 388 SER   B OG  1 
ATOM   5928 N N   . ILE   B 1 389 ? 11.457  -24.139 -70.953 1.00 60.52 ? 389 ILE   B N   1 
ATOM   5929 C CA  . ILE   B 1 389 ? 11.640  -22.875 -70.250 1.00 63.35 ? 389 ILE   B CA  1 
ATOM   5930 C C   . ILE   B 1 389 ? 12.658  -22.066 -71.045 1.00 63.60 ? 389 ILE   B C   1 
ATOM   5931 O O   . ILE   B 1 389 ? 13.867  -22.315 -70.965 1.00 63.61 ? 389 ILE   B O   1 
ATOM   5932 C CB  . ILE   B 1 389 ? 12.081  -23.083 -68.796 1.00 60.67 ? 389 ILE   B CB  1 
ATOM   5933 C CG1 . ILE   B 1 389 ? 10.985  -23.818 -68.019 1.00 57.49 ? 389 ILE   B CG1 1 
ATOM   5934 C CG2 . ILE   B 1 389 ? 12.415  -21.749 -68.139 1.00 58.00 ? 389 ILE   B CG2 1 
ATOM   5935 C CD1 . ILE   B 1 389 ? 11.123  -23.734 -66.516 1.00 57.19 ? 389 ILE   B CD1 1 
ATOM   5936 N N   . ASP   B 1 390 ? 12.163  -21.101 -71.822 1.00 63.69 ? 390 ASP   B N   1 
ATOM   5937 C CA  . ASP   B 1 390 ? 12.993  -20.250 -72.678 1.00 65.31 ? 390 ASP   B CA  1 
ATOM   5938 C C   . ASP   B 1 390 ? 13.851  -21.092 -73.620 1.00 64.32 ? 390 ASP   B C   1 
ATOM   5939 O O   . ASP   B 1 390 ? 15.050  -20.858 -73.794 1.00 62.87 ? 390 ASP   B O   1 
ATOM   5940 C CB  . ASP   B 1 390 ? 13.858  -19.303 -71.843 1.00 62.51 ? 390 ASP   B CB  1 
ATOM   5941 C CG  . ASP   B 1 390 ? 13.040  -18.243 -71.125 1.00 64.29 ? 390 ASP   B CG  1 
ATOM   5942 O OD1 . ASP   B 1 390 ? 12.014  -17.803 -71.681 1.00 63.00 ? 390 ASP   B OD1 1 
ATOM   5943 O OD2 . ASP   B 1 390 ? 13.428  -17.847 -70.007 1.00 58.81 ? 390 ASP   B OD2 1 
ATOM   5944 N N   . GLY   B 1 391 ? 13.219  -22.087 -74.242 1.00 66.18 ? 391 GLY   B N   1 
ATOM   5945 C CA  . GLY   B 1 391 ? 13.911  -23.013 -75.113 1.00 67.21 ? 391 GLY   B CA  1 
ATOM   5946 C C   . GLY   B 1 391 ? 14.689  -24.100 -74.405 1.00 69.70 ? 391 GLY   B C   1 
ATOM   5947 O O   . GLY   B 1 391 ? 14.908  -25.166 -74.988 1.00 73.93 ? 391 GLY   B O   1 
ATOM   5948 N N   . GLY   B 1 392 ? 15.117  -23.869 -73.170 1.00 67.32 ? 392 GLY   B N   1 
ATOM   5949 C CA  . GLY   B 1 392 ? 15.796  -24.883 -72.399 1.00 65.68 ? 392 GLY   B CA  1 
ATOM   5950 C C   . GLY   B 1 392 ? 14.842  -25.974 -71.947 1.00 67.31 ? 392 GLY   B C   1 
ATOM   5951 O O   . GLY   B 1 392 ? 13.627  -25.929 -72.153 1.00 68.64 ? 392 GLY   B O   1 
ATOM   5952 N N   . ILE   B 1 393 ? 15.421  -26.982 -71.304 1.00 66.49 ? 393 ILE   B N   1 
ATOM   5953 C CA  . ILE   B 1 393 ? 14.685  -28.146 -70.826 1.00 64.45 ? 393 ILE   B CA  1 
ATOM   5954 C C   . ILE   B 1 393 ? 14.845  -28.216 -69.315 1.00 64.77 ? 393 ILE   B C   1 
ATOM   5955 O O   . ILE   B 1 393 ? 15.963  -28.374 -68.810 1.00 65.19 ? 393 ILE   B O   1 
ATOM   5956 C CB  . ILE   B 1 393 ? 15.169  -29.443 -71.493 1.00 64.26 ? 393 ILE   B CB  1 
ATOM   5957 C CG1 . ILE   B 1 393 ? 15.109  -29.308 -73.017 1.00 68.52 ? 393 ILE   B CG1 1 
ATOM   5958 C CG2 . ILE   B 1 393 ? 14.330  -30.623 -71.032 1.00 64.41 ? 393 ILE   B CG2 1 
ATOM   5959 C CD1 . ILE   B 1 393 ? 13.730  -28.988 -73.551 1.00 69.37 ? 393 ILE   B CD1 1 
ATOM   5960 N N   . ALA   B 1 394 ? 13.730  -28.106 -68.598 1.00 60.99 ? 394 ALA   B N   1 
ATOM   5961 C CA  . ALA   B 1 394 ? 13.730  -28.093 -67.146 1.00 57.78 ? 394 ALA   B CA  1 
ATOM   5962 C C   . ALA   B 1 394 ? 12.915  -29.262 -66.606 1.00 55.34 ? 394 ALA   B C   1 
ATOM   5963 O O   . ALA   B 1 394 ? 11.979  -29.725 -67.265 1.00 57.34 ? 394 ALA   B O   1 
ATOM   5964 C CB  . ALA   B 1 394 ? 13.155  -26.775 -66.610 1.00 56.03 ? 394 ALA   B CB  1 
ATOM   5965 N N   . PRO   B 1 395 ? 13.248  -29.765 -65.417 1.00 57.31 ? 395 PRO   B N   1 
ATOM   5966 C CA  . PRO   B 1 395 ? 12.470  -30.871 -64.847 1.00 58.62 ? 395 PRO   B CA  1 
ATOM   5967 C C   . PRO   B 1 395 ? 11.036  -30.451 -64.556 1.00 58.62 ? 395 PRO   B C   1 
ATOM   5968 O O   . PRO   B 1 395 ? 10.771  -29.340 -64.092 1.00 55.35 ? 395 PRO   B O   1 
ATOM   5969 C CB  . PRO   B 1 395 ? 13.231  -31.217 -63.562 1.00 57.30 ? 395 PRO   B CB  1 
ATOM   5970 C CG  . PRO   B 1 395 ? 14.023  -29.987 -63.240 1.00 58.74 ? 395 PRO   B CG  1 
ATOM   5971 C CD  . PRO   B 1 395 ? 14.390  -29.394 -64.562 1.00 57.07 ? 395 PRO   B CD  1 
ATOM   5972 N N   . PHE   B 1 396 ? 10.106  -31.366 -64.836 1.00 57.34 ? 396 PHE   B N   1 
ATOM   5973 C CA  . PHE   B 1 396 ? 8.685   -31.068 -64.684 1.00 52.47 ? 396 PHE   B CA  1 
ATOM   5974 C C   . PHE   B 1 396 ? 8.288   -30.969 -63.216 1.00 52.76 ? 396 PHE   B C   1 
ATOM   5975 O O   . PHE   B 1 396 ? 7.650   -29.993 -62.800 1.00 52.53 ? 396 PHE   B O   1 
ATOM   5976 C CB  . PHE   B 1 396 ? 7.854   -32.143 -65.390 1.00 53.60 ? 396 PHE   B CB  1 
ATOM   5977 C CG  . PHE   B 1 396 ? 6.388   -31.816 -65.501 1.00 52.75 ? 396 PHE   B CG  1 
ATOM   5978 C CD1 . PHE   B 1 396 ? 5.523   -32.024 -64.434 1.00 52.14 ? 396 PHE   B CD1 1 
ATOM   5979 C CD2 . PHE   B 1 396 ? 5.871   -31.324 -66.686 1.00 53.83 ? 396 PHE   B CD2 1 
ATOM   5980 C CE1 . PHE   B 1 396 ? 4.173   -31.729 -64.547 1.00 51.74 ? 396 PHE   B CE1 1 
ATOM   5981 C CE2 . PHE   B 1 396 ? 4.523   -31.031 -66.807 1.00 50.25 ? 396 PHE   B CE2 1 
ATOM   5982 C CZ  . PHE   B 1 396 ? 3.673   -31.232 -65.737 1.00 54.49 ? 396 PHE   B CZ  1 
ATOM   5983 N N   . ALA   B 1 397 ? 8.647   -31.980 -62.420 1.00 54.14 ? 397 ALA   B N   1 
ATOM   5984 C CA  . ALA   B 1 397 ? 8.099   -32.091 -61.073 1.00 51.26 ? 397 ALA   B CA  1 
ATOM   5985 C C   . ALA   B 1 397 ? 8.628   -31.004 -60.142 1.00 49.91 ? 397 ALA   B C   1 
ATOM   5986 O O   . ALA   B 1 397 ? 7.972   -30.674 -59.148 1.00 50.28 ? 397 ALA   B O   1 
ATOM   5987 C CB  . ALA   B 1 397 ? 8.407   -33.471 -60.497 1.00 47.75 ? 397 ALA   B CB  1 
ATOM   5988 N N   . ALA   B 1 398 ? 9.808   -30.445 -60.435 1.00 52.20 ? 398 ALA   B N   1 
ATOM   5989 C CA  . ALA   B 1 398 ? 10.395  -29.422 -59.574 1.00 48.59 ? 398 ALA   B CA  1 
ATOM   5990 C C   . ALA   B 1 398 ? 9.544   -28.162 -59.486 1.00 48.50 ? 398 ALA   B C   1 
ATOM   5991 O O   . ALA   B 1 398 ? 9.736   -27.372 -58.557 1.00 46.94 ? 398 ALA   B O   1 
ATOM   5992 C CB  . ALA   B 1 398 ? 11.802  -29.075 -60.067 1.00 49.86 ? 398 ALA   B CB  1 
ATOM   5993 N N   . GLN   B 1 399 ? 8.615   -27.959 -60.423 1.00 49.13 ? 399 GLN   B N   1 
ATOM   5994 C CA  . GLN   B 1 399 ? 7.739   -26.794 -60.406 1.00 47.75 ? 399 GLN   B CA  1 
ATOM   5995 C C   . GLN   B 1 399 ? 6.756   -26.802 -59.243 1.00 46.17 ? 399 GLN   B C   1 
ATOM   5996 O O   . GLN   B 1 399 ? 6.076   -25.792 -59.028 1.00 45.19 ? 399 GLN   B O   1 
ATOM   5997 C CB  . GLN   B 1 399 ? 6.981   -26.702 -61.729 1.00 47.06 ? 399 GLN   B CB  1 
ATOM   5998 C CG  . GLN   B 1 399 ? 7.886   -26.513 -62.932 1.00 49.20 ? 399 GLN   B CG  1 
ATOM   5999 C CD  . GLN   B 1 399 ? 8.493   -25.129 -62.993 1.00 49.31 ? 399 GLN   B CD  1 
ATOM   6000 O OE1 . GLN   B 1 399 ? 7.866   -24.149 -62.597 1.00 48.32 ? 399 GLN   B OE1 1 
ATOM   6001 N NE2 . GLN   B 1 399 ? 9.719   -25.040 -63.492 1.00 46.04 ? 399 GLN   B NE2 1 
ATOM   6002 N N   . LEU   B 1 400 ? 6.666   -27.902 -58.490 1.00 47.69 ? 400 LEU   B N   1 
ATOM   6003 C CA  . LEU   B 1 400 ? 5.877   -27.908 -57.262 1.00 48.30 ? 400 LEU   B CA  1 
ATOM   6004 C C   . LEU   B 1 400 ? 6.397   -26.907 -56.237 1.00 45.41 ? 400 LEU   B C   1 
ATOM   6005 O O   . LEU   B 1 400 ? 5.702   -26.627 -55.252 1.00 47.03 ? 400 LEU   B O   1 
ATOM   6006 C CB  . LEU   B 1 400 ? 5.869   -29.309 -56.643 1.00 48.62 ? 400 LEU   B CB  1 
ATOM   6007 C CG  . LEU   B 1 400 ? 4.898   -30.352 -57.196 1.00 53.64 ? 400 LEU   B CG  1 
ATOM   6008 C CD1 . LEU   B 1 400 ? 5.345   -31.743 -56.789 1.00 54.41 ? 400 LEU   B CD1 1 
ATOM   6009 C CD2 . LEU   B 1 400 ? 3.488   -30.078 -56.703 1.00 50.04 ? 400 LEU   B CD2 1 
ATOM   6010 N N   . GLY   B 1 401 ? 7.601   -26.368 -56.445 1.00 45.69 ? 401 GLY   B N   1 
ATOM   6011 C CA  . GLY   B 1 401 ? 8.174   -25.448 -55.474 1.00 46.13 ? 401 GLY   B CA  1 
ATOM   6012 C C   . GLY   B 1 401 ? 7.360   -24.179 -55.317 1.00 48.53 ? 401 GLY   B C   1 
ATOM   6013 O O   . GLY   B 1 401 ? 7.082   -23.740 -54.197 1.00 51.57 ? 401 GLY   B O   1 
ATOM   6014 N N   . TRP   B 1 402 ? 6.962   -23.569 -56.439 1.00 46.94 ? 402 TRP   B N   1 
ATOM   6015 C CA  . TRP   B 1 402 ? 6.122   -22.377 -56.371 1.00 46.24 ? 402 TRP   B CA  1 
ATOM   6016 C C   . TRP   B 1 402 ? 4.794   -22.652 -55.680 1.00 45.50 ? 402 TRP   B C   1 
ATOM   6017 O O   . TRP   B 1 402 ? 4.145   -21.714 -55.209 1.00 46.86 ? 402 TRP   B O   1 
ATOM   6018 C CB  . TRP   B 1 402 ? 5.860   -21.827 -57.773 1.00 45.50 ? 402 TRP   B CB  1 
ATOM   6019 C CG  . TRP   B 1 402 ? 7.085   -21.704 -58.622 1.00 45.75 ? 402 TRP   B CG  1 
ATOM   6020 C CD1 . TRP   B 1 402 ? 7.481   -22.553 -59.614 1.00 48.01 ? 402 TRP   B CD1 1 
ATOM   6021 C CD2 . TRP   B 1 402 ? 8.075   -20.670 -58.560 1.00 46.65 ? 402 TRP   B CD2 1 
ATOM   6022 N NE1 . TRP   B 1 402 ? 8.656   -22.113 -60.174 1.00 50.16 ? 402 TRP   B NE1 1 
ATOM   6023 C CE2 . TRP   B 1 402 ? 9.043   -20.960 -59.543 1.00 48.45 ? 402 TRP   B CE2 1 
ATOM   6024 C CE3 . TRP   B 1 402 ? 8.238   -19.529 -57.767 1.00 48.04 ? 402 TRP   B CE3 1 
ATOM   6025 C CZ2 . TRP   B 1 402 ? 10.157  -20.151 -59.756 1.00 50.83 ? 402 TRP   B CZ2 1 
ATOM   6026 C CZ3 . TRP   B 1 402 ? 9.346   -18.728 -57.980 1.00 48.95 ? 402 TRP   B CZ3 1 
ATOM   6027 C CH2 . TRP   B 1 402 ? 10.290  -19.043 -58.967 1.00 47.51 ? 402 TRP   B CH2 1 
ATOM   6028 N N   . ILE   B 1 403 ? 4.385   -23.918 -55.604 1.00 44.77 ? 403 ILE   B N   1 
ATOM   6029 C CA  . ILE   B 1 403 ? 3.112   -24.283 -54.995 1.00 46.12 ? 403 ILE   B CA  1 
ATOM   6030 C C   . ILE   B 1 403 ? 3.244   -24.630 -53.516 1.00 44.50 ? 403 ILE   B C   1 
ATOM   6031 O O   . ILE   B 1 403 ? 2.266   -24.492 -52.766 1.00 43.89 ? 403 ILE   B O   1 
ATOM   6032 C CB  . ILE   B 1 403 ? 2.495   -25.450 -55.793 1.00 45.37 ? 403 ILE   B CB  1 
ATOM   6033 C CG1 . ILE   B 1 403 ? 1.265   -24.971 -56.563 1.00 45.52 ? 403 ILE   B CG1 1 
ATOM   6034 C CG2 . ILE   B 1 403 ? 2.152   -26.645 -54.898 1.00 45.53 ? 403 ILE   B CG2 1 
ATOM   6035 C CD1 . ILE   B 1 403 ? 1.488   -23.709 -57.360 1.00 45.78 ? 403 ILE   B CD1 1 
ATOM   6036 N N   . SER   B 1 404 ? 4.438   -25.020 -53.065 1.00 43.18 ? 404 SER   B N   1 
ATOM   6037 C CA  . SER   B 1 404 ? 4.580   -25.659 -51.759 1.00 44.88 ? 404 SER   B CA  1 
ATOM   6038 C C   . SER   B 1 404 ? 4.374   -24.692 -50.598 1.00 44.66 ? 404 SER   B C   1 
ATOM   6039 O O   . SER   B 1 404 ? 3.892   -25.106 -49.537 1.00 43.94 ? 404 SER   B O   1 
ATOM   6040 C CB  . SER   B 1 404 ? 5.956   -26.315 -51.646 1.00 46.10 ? 404 SER   B CB  1 
ATOM   6041 O OG  . SER   B 1 404 ? 6.990   -25.361 -51.811 1.00 46.38 ? 404 SER   B OG  1 
ATOM   6042 N N   . MET   B 1 405 ? 4.735   -23.417 -50.766 1.00 43.86 ? 405 MET   B N   1 
ATOM   6043 C CA  . MET   B 1 405 ? 4.740   -22.490 -49.635 1.00 43.71 ? 405 MET   B CA  1 
ATOM   6044 C C   . MET   B 1 405 ? 3.347   -22.325 -49.036 1.00 42.09 ? 405 MET   B C   1 
ATOM   6045 O O   . MET   B 1 405 ? 3.163   -22.460 -47.820 1.00 39.10 ? 405 MET   B O   1 
ATOM   6046 C CB  . MET   B 1 405 ? 5.304   -21.135 -50.066 1.00 43.26 ? 405 MET   B CB  1 
ATOM   6047 C CG  . MET   B 1 405 ? 6.768   -21.165 -50.479 1.00 44.90 ? 405 MET   B CG  1 
ATOM   6048 S SD  . MET   B 1 405 ? 7.006   -21.052 -52.262 1.00 58.93 ? 405 MET   B SD  1 
ATOM   6049 C CE  . MET   B 1 405 ? 6.240   -19.467 -52.606 1.00 51.24 ? 405 MET   B CE  1 
ATOM   6050 N N   . ALA   B 1 406 ? 2.349   -22.030 -49.873 1.00 42.27 ? 406 ALA   B N   1 
ATOM   6051 C CA  . ALA   B 1 406 ? 1.003   -21.802 -49.358 1.00 40.79 ? 406 ALA   B CA  1 
ATOM   6052 C C   . ALA   B 1 406 ? 0.339   -23.094 -48.901 1.00 43.27 ? 406 ALA   B C   1 
ATOM   6053 O O   . ALA   B 1 406 ? -0.494  -23.071 -47.988 1.00 40.64 ? 406 ALA   B O   1 
ATOM   6054 C CB  . ALA   B 1 406 ? 0.142   -21.116 -50.416 1.00 37.89 ? 406 ALA   B CB  1 
ATOM   6055 N N   . THR   B 1 407 ? 0.685   -24.224 -49.518 1.00 42.05 ? 407 THR   B N   1 
ATOM   6056 C CA  . THR   B 1 407 ? 0.050   -25.489 -49.164 1.00 43.10 ? 407 THR   B CA  1 
ATOM   6057 C C   . THR   B 1 407 ? 0.631   -26.064 -47.877 1.00 42.10 ? 407 THR   B C   1 
ATOM   6058 O O   . THR   B 1 407 ? -0.113  -26.475 -46.980 1.00 43.39 ? 407 THR   B O   1 
ATOM   6059 C CB  . THR   B 1 407 ? 0.190   -26.486 -50.316 1.00 42.76 ? 407 THR   B CB  1 
ATOM   6060 O OG1 . THR   B 1 407 ? -0.492  -25.977 -51.469 1.00 42.75 ? 407 THR   B OG1 1 
ATOM   6061 C CG2 . THR   B 1 407 ? -0.411  -27.829 -49.940 1.00 43.68 ? 407 THR   B CG2 1 
ATOM   6062 N N   . TYR   B 1 408 ? 1.961   -26.095 -47.771 1.00 42.81 ? 408 TYR   B N   1 
ATOM   6063 C CA  . TYR   B 1 408 ? 2.597   -26.631 -46.572 1.00 40.93 ? 408 TYR   B CA  1 
ATOM   6064 C C   . TYR   B 1 408 ? 2.413   -25.696 -45.383 1.00 41.62 ? 408 TYR   B C   1 
ATOM   6065 O O   . TYR   B 1 408 ? 2.200   -26.152 -44.253 1.00 38.67 ? 408 TYR   B O   1 
ATOM   6066 C CB  . TYR   B 1 408 ? 4.081   -26.883 -46.839 1.00 41.48 ? 408 TYR   B CB  1 
ATOM   6067 C CG  . TYR   B 1 408 ? 4.785   -27.704 -45.779 1.00 45.33 ? 408 TYR   B CG  1 
ATOM   6068 C CD1 . TYR   B 1 408 ? 4.400   -29.013 -45.518 1.00 42.60 ? 408 TYR   B CD1 1 
ATOM   6069 C CD2 . TYR   B 1 408 ? 5.855   -27.181 -45.062 1.00 43.51 ? 408 TYR   B CD2 1 
ATOM   6070 C CE1 . TYR   B 1 408 ? 5.045   -29.769 -44.559 1.00 42.24 ? 408 TYR   B CE1 1 
ATOM   6071 C CE2 . TYR   B 1 408 ? 6.505   -27.931 -44.098 1.00 43.02 ? 408 TYR   B CE2 1 
ATOM   6072 C CZ  . TYR   B 1 408 ? 6.095   -29.223 -43.853 1.00 46.58 ? 408 TYR   B CZ  1 
ATOM   6073 O OH  . TYR   B 1 408 ? 6.740   -29.975 -42.902 1.00 48.15 ? 408 TYR   B OH  1 
ATOM   6074 N N   . GLY   B 1 409 ? 2.489   -24.382 -45.619 1.00 41.89 ? 409 GLY   B N   1 
ATOM   6075 C CA  . GLY   B 1 409 ? 2.283   -23.417 -44.553 1.00 40.38 ? 409 GLY   B CA  1 
ATOM   6076 C C   . GLY   B 1 409 ? 0.833   -23.134 -44.227 1.00 43.28 ? 409 GLY   B C   1 
ATOM   6077 O O   . GLY   B 1 409 ? 0.546   -22.583 -43.160 1.00 43.10 ? 409 GLY   B O   1 
ATOM   6078 N N   . GLY   B 1 410 ? -0.086  -23.493 -45.123 1.00 40.81 ? 410 GLY   B N   1 
ATOM   6079 C CA  . GLY   B 1 410 ? -1.502  -23.317 -44.892 1.00 38.11 ? 410 GLY   B CA  1 
ATOM   6080 C C   . GLY   B 1 410 ? -2.056  -21.962 -45.267 1.00 41.65 ? 410 GLY   B C   1 
ATOM   6081 O O   . GLY   B 1 410 ? -3.273  -21.759 -45.163 1.00 42.15 ? 410 GLY   B O   1 
ATOM   6082 N N   . MET   B 1 411 ? -1.208  -21.031 -45.696 1.00 41.75 ? 411 MET   B N   1 
ATOM   6083 C CA  . MET   B 1 411 ? -1.645  -19.681 -46.002 1.00 38.40 ? 411 MET   B CA  1 
ATOM   6084 C C   . MET   B 1 411 ? -2.603  -19.670 -47.191 1.00 40.94 ? 411 MET   B C   1 
ATOM   6085 O O   . MET   B 1 411 ? -2.579  -20.571 -48.034 1.00 41.28 ? 411 MET   B O   1 
ATOM   6086 C CB  . MET   B 1 411 ? -0.443  -18.787 -46.303 1.00 41.07 ? 411 MET   B CB  1 
ATOM   6087 C CG  . MET   B 1 411 ? 0.487   -18.568 -45.127 1.00 44.41 ? 411 MET   B CG  1 
ATOM   6088 S SD  . MET   B 1 411 ? 1.780   -19.816 -45.030 1.00 43.16 ? 411 MET   B SD  1 
ATOM   6089 C CE  . MET   B 1 411 ? 2.672   -19.467 -46.541 1.00 42.62 ? 411 MET   B CE  1 
ATOM   6090 N N   . PRO   B 1 412 ? -3.465  -18.658 -47.274 1.00 41.37 ? 412 PRO   B N   1 
ATOM   6091 C CA  . PRO   B 1 412 ? -4.287  -18.487 -48.475 1.00 38.93 ? 412 PRO   B CA  1 
ATOM   6092 C C   . PRO   B 1 412 ? -3.467  -17.902 -49.615 1.00 42.52 ? 412 PRO   B C   1 
ATOM   6093 O O   . PRO   B 1 412 ? -2.587  -17.062 -49.410 1.00 41.37 ? 412 PRO   B O   1 
ATOM   6094 C CB  . PRO   B 1 412 ? -5.379  -17.514 -48.016 1.00 37.85 ? 412 PRO   B CB  1 
ATOM   6095 C CG  . PRO   B 1 412 ? -4.719  -16.714 -46.944 1.00 41.07 ? 412 PRO   B CG  1 
ATOM   6096 C CD  . PRO   B 1 412 ? -3.785  -17.660 -46.238 1.00 41.19 ? 412 PRO   B CD  1 
ATOM   6097 N N   . ALA   B 1 413 ? -3.763  -18.359 -50.830 1.00 35.95 ? 413 ALA   B N   1 
ATOM   6098 C CA  . ALA   B 1 413 ? -3.022  -17.939 -52.012 1.00 38.88 ? 413 ALA   B CA  1 
ATOM   6099 C C   . ALA   B 1 413 ? -3.994  -17.619 -53.135 1.00 39.50 ? 413 ALA   B C   1 
ATOM   6100 O O   . ALA   B 1 413 ? -4.837  -18.450 -53.484 1.00 37.08 ? 413 ALA   B O   1 
ATOM   6101 C CB  . ALA   B 1 413 ? -2.035  -19.023 -52.461 1.00 38.78 ? 413 ALA   B CB  1 
ATOM   6102 N N   . LEU   B 1 414 ? -3.871  -16.421 -53.700 1.00 43.78 ? 414 LEU   B N   1 
ATOM   6103 C CA  . LEU   B 1 414 ? -4.719  -15.985 -54.800 1.00 42.25 ? 414 LEU   B CA  1 
ATOM   6104 C C   . LEU   B 1 414 ? -3.973  -16.113 -56.121 1.00 41.19 ? 414 LEU   B C   1 
ATOM   6105 O O   . LEU   B 1 414 ? -2.794  -15.764 -56.216 1.00 41.19 ? 414 LEU   B O   1 
ATOM   6106 C CB  . LEU   B 1 414 ? -5.172  -14.537 -54.600 1.00 40.85 ? 414 LEU   B CB  1 
ATOM   6107 C CG  . LEU   B 1 414 ? -6.094  -13.966 -55.685 1.00 43.92 ? 414 LEU   B CG  1 
ATOM   6108 C CD1 . LEU   B 1 414 ? -7.455  -14.639 -55.650 1.00 43.65 ? 414 LEU   B CD1 1 
ATOM   6109 C CD2 . LEU   B 1 414 ? -6.233  -12.456 -55.557 1.00 43.18 ? 414 LEU   B CD2 1 
ATOM   6110 N N   . SER   B 1 415 ? -4.666  -16.615 -57.140 1.00 41.42 ? 415 SER   B N   1 
ATOM   6111 C CA  . SER   B 1 415 ? -4.138  -16.700 -58.499 1.00 39.37 ? 415 SER   B CA  1 
ATOM   6112 C C   . SER   B 1 415 ? -4.993  -15.811 -59.395 1.00 41.89 ? 415 SER   B C   1 
ATOM   6113 O O   . SER   B 1 415 ? -6.144  -16.148 -59.696 1.00 41.79 ? 415 SER   B O   1 
ATOM   6114 C CB  . SER   B 1 415 ? -4.128  -18.144 -59.001 1.00 41.17 ? 415 SER   B CB  1 
ATOM   6115 O OG  . SER   B 1 415 ? -3.573  -18.222 -60.303 1.00 39.77 ? 415 SER   B OG  1 
ATOM   6116 N N   . MET   B 1 416 ? -4.431  -14.681 -59.824 1.00 40.35 ? 416 MET   B N   1 
ATOM   6117 C CA  . MET   B 1 416 ? -5.181  -13.677 -60.560 1.00 41.41 ? 416 MET   B CA  1 
ATOM   6118 C C   . MET   B 1 416 ? -4.537  -13.393 -61.912 1.00 44.29 ? 416 MET   B C   1 
ATOM   6119 O O   . MET   B 1 416 ? -3.318  -13.517 -62.064 1.00 47.81 ? 416 MET   B O   1 
ATOM   6120 C CB  . MET   B 1 416 ? -5.282  -12.371 -59.760 1.00 40.14 ? 416 MET   B CB  1 
ATOM   6121 C CG  . MET   B 1 416 ? -3.939  -11.772 -59.375 1.00 43.19 ? 416 MET   B CG  1 
ATOM   6122 S SD  . MET   B 1 416 ? -4.075  -10.028 -58.939 1.00 51.73 ? 416 MET   B SD  1 
ATOM   6123 C CE  . MET   B 1 416 ? -4.672  -9.340  -60.482 1.00 41.78 ? 416 MET   B CE  1 
ATOM   6124 N N   . PRO   B 1 417 ? -5.332  -13.009 -62.912 1.00 41.61 ? 417 PRO   B N   1 
ATOM   6125 C CA  . PRO   B 1 417 ? -4.770  -12.749 -64.245 1.00 44.42 ? 417 PRO   B CA  1 
ATOM   6126 C C   . PRO   B 1 417 ? -3.805  -11.571 -64.233 1.00 43.41 ? 417 PRO   B C   1 
ATOM   6127 O O   . PRO   B 1 417 ? -4.110  -10.502 -63.701 1.00 44.16 ? 417 PRO   B O   1 
ATOM   6128 C CB  . PRO   B 1 417 ? -6.008  -12.454 -65.101 1.00 44.26 ? 417 PRO   B CB  1 
ATOM   6129 C CG  . PRO   B 1 417 ? -7.133  -13.127 -64.373 1.00 46.46 ? 417 PRO   B CG  1 
ATOM   6130 C CD  . PRO   B 1 417 ? -6.803  -12.954 -62.920 1.00 40.84 ? 417 PRO   B CD  1 
ATOM   6131 N N   . LEU   B 1 418 ? -2.636  -11.781 -64.836 1.00 44.06 ? 418 LEU   B N   1 
ATOM   6132 C CA  . LEU   B 1 418 ? -1.616  -10.755 -65.028 1.00 47.37 ? 418 LEU   B CA  1 
ATOM   6133 C C   . LEU   B 1 418 ? -1.493  -10.296 -66.470 1.00 49.23 ? 418 LEU   B C   1 
ATOM   6134 O O   . LEU   B 1 418 ? -1.421  -9.095  -66.721 1.00 50.55 ? 418 LEU   B O   1 
ATOM   6135 C CB  . LEU   B 1 418 ? -0.255  -11.275 -64.538 1.00 46.13 ? 418 LEU   B CB  1 
ATOM   6136 C CG  . LEU   B 1 418 ? 0.490   -10.530 -63.426 1.00 47.40 ? 418 LEU   B CG  1 
ATOM   6137 C CD1 . LEU   B 1 418 ? 1.761   -11.275 -63.041 1.00 48.50 ? 418 LEU   B CD1 1 
ATOM   6138 C CD2 . LEU   B 1 418 ? 0.812   -9.107  -63.849 1.00 49.72 ? 418 LEU   B CD2 1 
ATOM   6139 N N   . GLY   B 1 419 ? -1.480  -11.233 -67.415 1.00 50.63 ? 419 GLY   B N   1 
ATOM   6140 C CA  . GLY   B 1 419 ? -1.347  -10.959 -68.833 1.00 47.63 ? 419 GLY   B CA  1 
ATOM   6141 C C   . GLY   B 1 419 ? -1.160  -12.227 -69.641 1.00 48.60 ? 419 GLY   B C   1 
ATOM   6142 O O   . GLY   B 1 419 ? -1.786  -13.243 -69.341 1.00 47.54 ? 419 GLY   B O   1 
ATOM   6143 N N   . ALA   B 1 420 ? -0.298  -12.193 -70.651 1.00 52.81 ? 420 ALA   B N   1 
ATOM   6144 C CA  . ALA   B 1 420 ? -0.030  -13.374 -71.455 1.00 47.98 ? 420 ALA   B CA  1 
ATOM   6145 C C   . ALA   B 1 420 ? 1.424   -13.357 -71.908 1.00 48.02 ? 420 ALA   B C   1 
ATOM   6146 O O   . ALA   B 1 420 ? 2.117   -12.342 -71.808 1.00 50.75 ? 420 ALA   B O   1 
ATOM   6147 C CB  . ALA   B 1 420 ? -0.982  -13.462 -72.656 1.00 48.93 ? 420 ALA   B CB  1 
ATOM   6148 N N   . ASP   B 1 421 ? 1.884   -14.498 -72.427 1.00 50.31 ? 421 ASP   B N   1 
ATOM   6149 C CA  . ASP   B 1 421 ? 3.267   -14.619 -72.865 1.00 52.79 ? 421 ASP   B CA  1 
ATOM   6150 C C   . ASP   B 1 421 ? 3.353   -14.316 -74.366 1.00 53.99 ? 421 ASP   B C   1 
ATOM   6151 O O   . ASP   B 1 421 ? 2.486   -13.641 -74.929 1.00 51.91 ? 421 ASP   B O   1 
ATOM   6152 C CB  . ASP   B 1 421 ? 3.814   -16.000 -72.488 1.00 50.35 ? 421 ASP   B CB  1 
ATOM   6153 C CG  . ASP   B 1 421 ? 3.190   -17.127 -73.292 1.00 53.65 ? 421 ASP   B CG  1 
ATOM   6154 O OD1 . ASP   B 1 421 ? 2.147   -16.910 -73.935 1.00 53.60 ? 421 ASP   B OD1 1 
ATOM   6155 O OD2 . ASP   B 1 421 ? 3.754   -18.245 -73.276 1.00 51.80 ? 421 ASP   B OD2 1 
ATOM   6156 N N   . GLY   B 1 422 ? 4.412   -14.796 -75.024 1.00 55.61 ? 422 GLY   B N   1 
ATOM   6157 C CA  . GLY   B 1 422 ? 4.598   -14.503 -76.435 1.00 56.26 ? 422 GLY   B CA  1 
ATOM   6158 C C   . GLY   B 1 422 ? 3.613   -15.209 -77.341 1.00 58.18 ? 422 GLY   B C   1 
ATOM   6159 O O   . GLY   B 1 422 ? 3.344   -14.743 -78.451 1.00 61.51 ? 422 GLY   B O   1 
ATOM   6160 N N   . ASN   B 1 423 ? 3.064   -16.335 -76.891 1.00 56.88 ? 423 ASN   B N   1 
ATOM   6161 C CA  . ASN   B 1 423 ? 2.127   -17.119 -77.683 1.00 55.00 ? 423 ASN   B CA  1 
ATOM   6162 C C   . ASN   B 1 423 ? 0.673   -16.845 -77.318 1.00 54.08 ? 423 ASN   B C   1 
ATOM   6163 O O   . ASN   B 1 423 ? -0.222  -17.541 -77.810 1.00 53.43 ? 423 ASN   B O   1 
ATOM   6164 C CB  . ASN   B 1 423 ? 2.429   -18.612 -77.531 1.00 56.15 ? 423 ASN   B CB  1 
ATOM   6165 C CG  . ASN   B 1 423 ? 3.855   -18.958 -77.912 1.00 60.93 ? 423 ASN   B CG  1 
ATOM   6166 O OD1 . ASN   B 1 423 ? 4.431   -18.356 -78.820 1.00 60.42 ? 423 ASN   B OD1 1 
ATOM   6167 N ND2 . ASN   B 1 423 ? 4.432   -19.935 -77.223 1.00 63.49 ? 423 ASN   B ND2 1 
ATOM   6168 N N   . GLY   B 1 424 ? 0.417   -15.853 -76.471 1.00 54.04 ? 424 GLY   B N   1 
ATOM   6169 C CA  . GLY   B 1 424 ? -0.938  -15.575 -76.045 1.00 54.37 ? 424 GLY   B CA  1 
ATOM   6170 C C   . GLY   B 1 424 ? -1.446  -16.466 -74.937 1.00 53.28 ? 424 GLY   B C   1 
ATOM   6171 O O   . GLY   B 1 424 ? -2.655  -16.505 -74.691 1.00 50.16 ? 424 GLY   B O   1 
ATOM   6172 N N   . LEU   B 1 425 ? -0.561  -17.188 -74.263 1.00 52.51 ? 425 LEU   B N   1 
ATOM   6173 C CA  . LEU   B 1 425 ? -0.949  -18.056 -73.158 1.00 49.46 ? 425 LEU   B CA  1 
ATOM   6174 C C   . LEU   B 1 425 ? -0.949  -17.265 -71.854 1.00 47.62 ? 425 LEU   B C   1 
ATOM   6175 O O   . LEU   B 1 425 ? 0.019   -16.546 -71.573 1.00 46.19 ? 425 LEU   B O   1 
ATOM   6176 C CB  . LEU   B 1 425 ? -0.005  -19.247 -73.052 1.00 48.40 ? 425 LEU   B CB  1 
ATOM   6177 C CG  . LEU   B 1 425 ? 0.011   -20.195 -74.255 1.00 48.66 ? 425 LEU   B CG  1 
ATOM   6178 C CD1 . LEU   B 1 425 ? 1.024   -21.310 -74.050 1.00 48.59 ? 425 LEU   B CD1 1 
ATOM   6179 C CD2 . LEU   B 1 425 ? -1.381  -20.763 -74.499 1.00 46.34 ? 425 LEU   B CD2 1 
ATOM   6180 N N   . PRO   B 1 426 ? -2.005  -17.367 -71.050 1.00 48.22 ? 426 PRO   B N   1 
ATOM   6181 C CA  . PRO   B 1 426 ? -2.138  -16.482 -69.887 1.00 45.69 ? 426 PRO   B CA  1 
ATOM   6182 C C   . PRO   B 1 426 ? -1.070  -16.738 -68.837 1.00 45.12 ? 426 PRO   B C   1 
ATOM   6183 O O   . PRO   B 1 426 ? -0.589  -17.859 -68.660 1.00 42.66 ? 426 PRO   B O   1 
ATOM   6184 C CB  . PRO   B 1 426 ? -3.536  -16.815 -69.347 1.00 42.52 ? 426 PRO   B CB  1 
ATOM   6185 C CG  . PRO   B 1 426 ? -4.256  -17.450 -70.497 1.00 45.85 ? 426 PRO   B CG  1 
ATOM   6186 C CD  . PRO   B 1 426 ? -3.199  -18.207 -71.241 1.00 45.39 ? 426 PRO   B CD  1 
ATOM   6187 N N   . ILE   B 1 427 ? -0.694  -15.665 -68.145 1.00 45.37 ? 427 ILE   B N   1 
ATOM   6188 C CA  . ILE   B 1 427 ? 0.213   -15.718 -67.005 1.00 45.58 ? 427 ILE   B CA  1 
ATOM   6189 C C   . ILE   B 1 427 ? -0.511  -15.113 -65.812 1.00 45.44 ? 427 ILE   B C   1 
ATOM   6190 O O   . ILE   B 1 427 ? -1.140  -14.054 -65.934 1.00 45.46 ? 427 ILE   B O   1 
ATOM   6191 C CB  . ILE   B 1 427 ? 1.531   -14.969 -67.278 1.00 46.01 ? 427 ILE   B CB  1 
ATOM   6192 C CG1 . ILE   B 1 427 ? 2.062   -15.292 -68.673 1.00 45.78 ? 427 ILE   B CG1 1 
ATOM   6193 C CG2 . ILE   B 1 427 ? 2.569   -15.338 -66.234 1.00 41.98 ? 427 ILE   B CG2 1 
ATOM   6194 C CD1 . ILE   B 1 427 ? 3.317   -14.528 -69.036 1.00 43.17 ? 427 ILE   B CD1 1 
ATOM   6195 N N   . ASN   B 1 428 ? -0.429  -15.785 -64.667 1.00 44.25 ? 428 ASN   B N   1 
ATOM   6196 C CA  . ASN   B 1 428 ? -1.089  -15.341 -63.450 1.00 43.62 ? 428 ASN   B CA  1 
ATOM   6197 C C   . ASN   B 1 428 ? -0.065  -15.004 -62.375 1.00 44.65 ? 428 ASN   B C   1 
ATOM   6198 O O   . ASN   B 1 428 ? 1.091   -15.430 -62.424 1.00 43.95 ? 428 ASN   B O   1 
ATOM   6199 C CB  . ASN   B 1 428 ? -2.063  -16.405 -62.929 1.00 42.03 ? 428 ASN   B CB  1 
ATOM   6200 C CG  . ASN   B 1 428 ? -3.448  -16.282 -63.541 1.00 43.17 ? 428 ASN   B CG  1 
ATOM   6201 O OD1 . ASN   B 1 428 ? -3.609  -15.752 -64.640 1.00 45.60 ? 428 ASN   B OD1 1 
ATOM   6202 N ND2 . ASN   B 1 428 ? -4.458  -16.769 -62.824 1.00 40.78 ? 428 ASN   B ND2 1 
ATOM   6203 N N   . LEU   B 1 429 ? -0.511  -14.219 -61.401 1.00 44.85 ? 429 LEU   B N   1 
ATOM   6204 C CA  . LEU   B 1 429 ? 0.286   -13.872 -60.235 1.00 44.16 ? 429 LEU   B CA  1 
ATOM   6205 C C   . LEU   B 1 429 ? -0.233  -14.639 -59.028 1.00 43.07 ? 429 LEU   B C   1 
ATOM   6206 O O   . LEU   B 1 429 ? -1.444  -14.814 -58.867 1.00 43.99 ? 429 LEU   B O   1 
ATOM   6207 C CB  . LEU   B 1 429 ? 0.228   -12.366 -59.961 1.00 45.46 ? 429 LEU   B CB  1 
ATOM   6208 C CG  . LEU   B 1 429 ? 0.880   -11.866 -58.668 1.00 41.85 ? 429 LEU   B CG  1 
ATOM   6209 C CD1 . LEU   B 1 429 ? 2.388   -12.068 -58.714 1.00 42.20 ? 429 LEU   B CD1 1 
ATOM   6210 C CD2 . LEU   B 1 429 ? 0.533   -10.408 -58.392 1.00 41.53 ? 429 LEU   B CD2 1 
ATOM   6211 N N   . GLN   B 1 430 ? 0.685   -15.108 -58.189 1.00 43.23 ? 430 GLN   B N   1 
ATOM   6212 C CA  . GLN   B 1 430 ? 0.321   -15.741 -56.930 1.00 41.14 ? 430 GLN   B CA  1 
ATOM   6213 C C   . GLN   B 1 430 ? 0.520   -14.745 -55.796 1.00 44.64 ? 430 GLN   B C   1 
ATOM   6214 O O   . GLN   B 1 430 ? 1.608   -14.181 -55.640 1.00 43.58 ? 430 GLN   B O   1 
ATOM   6215 C CB  . GLN   B 1 430 ? 1.142   -17.003 -56.675 1.00 40.22 ? 430 GLN   B CB  1 
ATOM   6216 C CG  . GLN   B 1 430 ? 0.724   -17.744 -55.413 1.00 40.63 ? 430 GLN   B CG  1 
ATOM   6217 C CD  . GLN   B 1 430 ? 1.498   -19.026 -55.209 1.00 41.46 ? 430 GLN   B CD  1 
ATOM   6218 O OE1 . GLN   B 1 430 ? 1.146   -19.849 -54.361 1.00 44.51 ? 430 GLN   B OE1 1 
ATOM   6219 N NE2 . GLN   B 1 430 ? 2.560   -19.207 -55.987 1.00 40.21 ? 430 GLN   B NE2 1 
ATOM   6220 N N   . ILE   B 1 431 ? -0.533  -14.529 -55.014 1.00 43.32 ? 431 ILE   B N   1 
ATOM   6221 C CA  . ILE   B 1 431 ? -0.520  -13.585 -53.904 1.00 42.48 ? 431 ILE   B CA  1 
ATOM   6222 C C   . ILE   B 1 431 ? -0.728  -14.383 -52.626 1.00 42.83 ? 431 ILE   B C   1 
ATOM   6223 O O   . ILE   B 1 431 ? -1.808  -14.947 -52.404 1.00 43.49 ? 431 ILE   B O   1 
ATOM   6224 C CB  . ILE   B 1 431 ? -1.593  -12.499 -54.056 1.00 42.74 ? 431 ILE   B CB  1 
ATOM   6225 C CG1 . ILE   B 1 431 ? -1.431  -11.773 -55.392 1.00 43.11 ? 431 ILE   B CG1 1 
ATOM   6226 C CG2 . ILE   B 1 431 ? -1.512  -11.516 -52.906 1.00 39.63 ? 431 ILE   B CG2 1 
ATOM   6227 C CD1 . ILE   B 1 431 ? -2.444  -10.672 -55.607 1.00 41.22 ? 431 ILE   B CD1 1 
ATOM   6228 N N   . ILE   B 1 432 ? 0.299   -14.431 -51.784 1.00 41.04 ? 432 ILE   B N   1 
ATOM   6229 C CA  . ILE   B 1 432 ? 0.272   -15.179 -50.534 1.00 42.81 ? 432 ILE   B CA  1 
ATOM   6230 C C   . ILE   B 1 432 ? 0.179   -14.187 -49.383 1.00 43.20 ? 432 ILE   B C   1 
ATOM   6231 O O   . ILE   B 1 432 ? 1.010   -13.279 -49.273 1.00 40.11 ? 432 ILE   B O   1 
ATOM   6232 C CB  . ILE   B 1 432 ? 1.518   -16.067 -50.382 1.00 44.03 ? 432 ILE   B CB  1 
ATOM   6233 C CG1 . ILE   B 1 432 ? 1.792   -16.843 -51.669 1.00 42.09 ? 432 ILE   B CG1 1 
ATOM   6234 C CG2 . ILE   B 1 432 ? 1.343   -17.020 -49.210 1.00 41.88 ? 432 ILE   B CG2 1 
ATOM   6235 C CD1 . ILE   B 1 432 ? 3.092   -17.617 -51.637 1.00 40.52 ? 432 ILE   B CD1 1 
ATOM   6236 N N   . THR   B 1 433 ? -0.824  -14.360 -48.531 1.00 42.02 ? 433 THR   B N   1 
ATOM   6237 C CA  . THR   B 1 433 ? -0.991  -13.564 -47.321 1.00 43.41 ? 433 THR   B CA  1 
ATOM   6238 C C   . THR   B 1 433 ? -0.986  -14.492 -46.110 1.00 43.59 ? 433 THR   B C   1 
ATOM   6239 O O   . THR   B 1 433 ? -0.944  -15.717 -46.241 1.00 40.82 ? 433 THR   B O   1 
ATOM   6240 C CB  . THR   B 1 433 ? -2.278  -12.736 -47.380 1.00 43.68 ? 433 THR   B CB  1 
ATOM   6241 O OG1 . THR   B 1 433 ? -3.405  -13.608 -47.523 1.00 46.36 ? 433 THR   B OG1 1 
ATOM   6242 C CG2 . THR   B 1 433 ? -2.236  -11.775 -48.559 1.00 41.23 ? 433 THR   B CG2 1 
ATOM   6243 N N   . ARG   B 1 434 ? -1.035  -13.899 -44.920 1.00 44.07 ? 434 ARG   B N   1 
ATOM   6244 C CA  . ARG   B 1 434 ? -0.953  -14.693 -43.705 1.00 45.72 ? 434 ARG   B CA  1 
ATOM   6245 C C   . ARG   B 1 434 ? -2.210  -15.540 -43.526 1.00 44.18 ? 434 ARG   B C   1 
ATOM   6246 O O   . ARG   B 1 434 ? -3.256  -15.294 -44.135 1.00 43.75 ? 434 ARG   B O   1 
ATOM   6247 C CB  . ARG   B 1 434 ? -0.740  -13.799 -42.483 1.00 44.05 ? 434 ARG   B CB  1 
ATOM   6248 C CG  . ARG   B 1 434 ? -1.921  -12.907 -42.142 1.00 43.56 ? 434 ARG   B CG  1 
ATOM   6249 C CD  . ARG   B 1 434 ? -1.643  -12.115 -40.877 1.00 47.69 ? 434 ARG   B CD  1 
ATOM   6250 N NE  . ARG   B 1 434 ? -2.541  -10.976 -40.731 1.00 48.11 ? 434 ARG   B NE  1 
ATOM   6251 C CZ  . ARG   B 1 434 ? -3.679  -10.995 -40.053 1.00 54.66 ? 434 ARG   B CZ  1 
ATOM   6252 N NH1 . ARG   B 1 434 ? -4.099  -12.089 -39.441 1.00 55.13 ? 434 ARG   B NH1 1 
ATOM   6253 N NH2 . ARG   B 1 434 ? -4.416  -9.890  -39.992 1.00 56.28 ? 434 ARG   B NH2 1 
ATOM   6254 N N   . ASN   B 1 435 ? -2.086  -16.555 -42.675 1.00 42.58 ? 435 ASN   B N   1 
ATOM   6255 C CA  . ASN   B 1 435 ? -3.177  -17.494 -42.455 1.00 42.58 ? 435 ASN   B CA  1 
ATOM   6256 C C   . ASN   B 1 435 ? -4.409  -16.769 -41.920 1.00 44.47 ? 435 ASN   B C   1 
ATOM   6257 O O   . ASN   B 1 435 ? -4.307  -15.878 -41.074 1.00 45.99 ? 435 ASN   B O   1 
ATOM   6258 C CB  . ASN   B 1 435 ? -2.739  -18.587 -41.480 1.00 44.75 ? 435 ASN   B CB  1 
ATOM   6259 C CG  . ASN   B 1 435 ? -1.578  -19.414 -42.010 1.00 48.59 ? 435 ASN   B CG  1 
ATOM   6260 O OD1 . ASN   B 1 435 ? -0.430  -18.969 -42.006 1.00 54.40 ? 435 ASN   B OD1 1 
ATOM   6261 N ND2 . ASN   B 1 435 ? -1.871  -20.628 -42.456 1.00 47.54 ? 435 ASN   B ND2 1 
ATOM   6262 N N   . TRP   B 1 436 ? -5.577  -17.154 -42.433 1.00 40.07 ? 436 TRP   B N   1 
ATOM   6263 C CA  . TRP   B 1 436 ? -6.891  -16.629 -42.067 1.00 43.10 ? 436 TRP   B CA  1 
ATOM   6264 C C   . TRP   B 1 436 ? -7.126  -15.214 -42.574 1.00 44.43 ? 436 TRP   B C   1 
ATOM   6265 O O   . TRP   B 1 436 ? -8.108  -14.574 -42.172 1.00 45.78 ? 436 TRP   B O   1 
ATOM   6266 C CB  . TRP   B 1 436 ? -7.129  -16.671 -40.553 1.00 43.07 ? 436 TRP   B CB  1 
ATOM   6267 C CG  . TRP   B 1 436 ? -6.917  -18.029 -39.973 1.00 44.57 ? 436 TRP   B CG  1 
ATOM   6268 C CD1 . TRP   B 1 436 ? -5.822  -18.468 -39.286 1.00 44.02 ? 436 TRP   B CD1 1 
ATOM   6269 C CD2 . TRP   B 1 436 ? -7.810  -19.140 -40.058 1.00 41.39 ? 436 TRP   B CD2 1 
ATOM   6270 N NE1 . TRP   B 1 436 ? -5.983  -19.786 -38.934 1.00 42.65 ? 436 TRP   B NE1 1 
ATOM   6271 C CE2 . TRP   B 1 436 ? -7.198  -20.221 -39.395 1.00 38.40 ? 436 TRP   B CE2 1 
ATOM   6272 C CE3 . TRP   B 1 436 ? -9.071  -19.326 -40.630 1.00 40.51 ? 436 TRP   B CE3 1 
ATOM   6273 C CZ2 . TRP   B 1 436 ? -7.806  -21.467 -39.285 1.00 38.88 ? 436 TRP   B CZ2 1 
ATOM   6274 C CZ3 . TRP   B 1 436 ? -9.671  -20.559 -40.523 1.00 41.64 ? 436 TRP   B CZ3 1 
ATOM   6275 C CH2 . TRP   B 1 436 ? -9.040  -21.617 -39.857 1.00 38.42 ? 436 TRP   B CH2 1 
ATOM   6276 N N   . SER   B 1 437 ? -6.252  -14.701 -43.438 1.00 42.37 ? 437 SER   B N   1 
ATOM   6277 C CA  . SER   B 1 437 ? -6.461  -13.432 -44.132 1.00 43.67 ? 437 SER   B CA  1 
ATOM   6278 C C   . SER   B 1 437 ? -6.866  -13.662 -45.582 1.00 44.98 ? 437 SER   B C   1 
ATOM   6279 O O   . SER   B 1 437 ? -6.349  -13.012 -46.495 1.00 44.64 ? 437 SER   B O   1 
ATOM   6280 C CB  . SER   B 1 437 ? -5.206  -12.569 -44.058 1.00 42.12 ? 437 SER   B CB  1 
ATOM   6281 O OG  . SER   B 1 437 ? -4.126  -13.198 -44.720 1.00 44.26 ? 437 SER   B OG  1 
ATOM   6282 N N   . ASP   B 1 438 ? -7.788  -14.603 -45.810 1.00 42.33 ? 438 ASP   B N   1 
ATOM   6283 C CA  . ASP   B 1 438 ? -8.208  -14.933 -47.169 1.00 41.75 ? 438 ASP   B CA  1 
ATOM   6284 C C   . ASP   B 1 438 ? -8.808  -13.726 -47.873 1.00 43.49 ? 438 ASP   B C   1 
ATOM   6285 O O   . ASP   B 1 438 ? -8.625  -13.548 -49.082 1.00 41.58 ? 438 ASP   B O   1 
ATOM   6286 C CB  . ASP   B 1 438 ? -9.214  -16.082 -47.136 1.00 41.49 ? 438 ASP   B CB  1 
ATOM   6287 C CG  . ASP   B 1 438 ? -8.679  -17.305 -46.426 1.00 44.60 ? 438 ASP   B CG  1 
ATOM   6288 O OD1 . ASP   B 1 438 ? -8.290  -17.185 -45.246 1.00 41.42 ? 438 ASP   B OD1 1 
ATOM   6289 O OD2 . ASP   B 1 438 ? -8.664  -18.389 -47.040 1.00 41.68 ? 438 ASP   B OD2 1 
ATOM   6290 N N   . HIS   B 1 439 ? -9.532  -12.884 -47.133 1.00 41.90 ? 439 HIS   B N   1 
ATOM   6291 C CA  . HIS   B 1 439 ? -10.120 -11.697 -47.742 1.00 42.49 ? 439 HIS   B CA  1 
ATOM   6292 C C   . HIS   B 1 439 ? -9.062  -10.653 -48.075 1.00 42.79 ? 439 HIS   B C   1 
ATOM   6293 O O   . HIS   B 1 439 ? -9.252  -9.858  -49.001 1.00 42.90 ? 439 HIS   B O   1 
ATOM   6294 C CB  . HIS   B 1 439 ? -11.193 -11.111 -46.823 1.00 42.91 ? 439 HIS   B CB  1 
ATOM   6295 C CG  . HIS   B 1 439 ? -12.511 -11.818 -46.908 1.00 42.55 ? 439 HIS   B CG  1 
ATOM   6296 N ND1 . HIS   B 1 439 ? -13.363 -11.676 -47.981 1.00 45.01 ? 439 HIS   B ND1 1 
ATOM   6297 C CD2 . HIS   B 1 439 ? -13.126 -12.667 -46.051 1.00 46.19 ? 439 HIS   B CD2 1 
ATOM   6298 C CE1 . HIS   B 1 439 ? -14.444 -12.411 -47.785 1.00 43.68 ? 439 HIS   B CE1 1 
ATOM   6299 N NE2 . HIS   B 1 439 ? -14.326 -13.020 -46.619 1.00 45.04 ? 439 HIS   B NE2 1 
ATOM   6300 N N   . ASP   B 1 440 ? -7.947  -10.637 -47.340 1.00 42.42 ? 440 ASP   B N   1 
ATOM   6301 C CA  . ASP   B 1 440 ? -6.852  -9.736  -47.687 1.00 43.48 ? 440 ASP   B CA  1 
ATOM   6302 C C   . ASP   B 1 440 ? -6.250  -10.100 -49.038 1.00 40.89 ? 440 ASP   B C   1 
ATOM   6303 O O   . ASP   B 1 440 ? -5.923  -9.215  -49.840 1.00 40.74 ? 440 ASP   B O   1 
ATOM   6304 C CB  . ASP   B 1 440 ? -5.780  -9.763  -46.597 1.00 43.69 ? 440 ASP   B CB  1 
ATOM   6305 C CG  . ASP   B 1 440 ? -6.137  -8.896  -45.410 1.00 47.74 ? 440 ASP   B CG  1 
ATOM   6306 O OD1 . ASP   B 1 440 ? -7.111  -8.125  -45.516 1.00 49.07 ? 440 ASP   B OD1 1 
ATOM   6307 O OD2 . ASP   B 1 440 ? -5.445  -8.979  -44.374 1.00 46.70 ? 440 ASP   B OD2 1 
ATOM   6308 N N   . ALA   B 1 441 ? -6.103  -11.400 -49.307 1.00 41.25 ? 441 ALA   B N   1 
ATOM   6309 C CA  . ALA   B 1 441 ? -5.570  -11.847 -50.590 1.00 44.25 ? 441 ALA   B CA  1 
ATOM   6310 C C   . ALA   B 1 441 ? -6.475  -11.419 -51.739 1.00 42.34 ? 441 ALA   B C   1 
ATOM   6311 O O   . ALA   B 1 441 ? -6.002  -10.897 -52.756 1.00 41.83 ? 441 ALA   B O   1 
ATOM   6312 C CB  . ALA   B 1 441 ? -5.394  -13.365 -50.577 1.00 41.75 ? 441 ALA   B CB  1 
ATOM   6313 N N   . ILE   B 1 442 ? -7.784  -11.636 -51.594 1.00 41.55 ? 442 ILE   B N   1 
ATOM   6314 C CA  . ILE   B 1 442 ? -8.731  -11.195 -52.615 1.00 42.21 ? 442 ILE   B CA  1 
ATOM   6315 C C   . ILE   B 1 442 ? -8.658  -9.684  -52.781 1.00 42.10 ? 442 ILE   B C   1 
ATOM   6316 O O   . ILE   B 1 442 ? -8.599  -9.164  -53.901 1.00 41.46 ? 442 ILE   B O   1 
ATOM   6317 C CB  . ILE   B 1 442 ? -10.160 -11.643 -52.259 1.00 42.39 ? 442 ILE   B CB  1 
ATOM   6318 C CG1 . ILE   B 1 442 ? -10.203 -13.140 -51.953 1.00 38.98 ? 442 ILE   B CG1 1 
ATOM   6319 C CG2 . ILE   B 1 442 ? -11.116 -11.309 -53.393 1.00 43.06 ? 442 ILE   B CG2 1 
ATOM   6320 C CD1 . ILE   B 1 442 ? -11.527 -13.602 -51.383 1.00 39.79 ? 442 ILE   B CD1 1 
ATOM   6321 N N   . ARG   B 1 443 ? -8.649  -8.958  -51.659 1.00 43.24 ? 443 ARG   B N   1 
ATOM   6322 C CA  . ARG   B 1 443 ? -8.643  -7.499  -51.704 1.00 42.65 ? 443 ARG   B CA  1 
ATOM   6323 C C   . ARG   B 1 443 ? -7.389  -6.969  -52.387 1.00 41.69 ? 443 ARG   B C   1 
ATOM   6324 O O   . ARG   B 1 443 ? -7.462  -6.060  -53.222 1.00 42.89 ? 443 ARG   B O   1 
ATOM   6325 C CB  . ARG   B 1 443 ? -8.768  -6.935  -50.288 1.00 43.82 ? 443 ARG   B CB  1 
ATOM   6326 C CG  . ARG   B 1 443 ? -8.483  -5.445  -50.175 1.00 44.26 ? 443 ARG   B CG  1 
ATOM   6327 C CD  . ARG   B 1 443 ? -9.428  -4.625  -51.038 1.00 44.69 ? 443 ARG   B CD  1 
ATOM   6328 N NE  . ARG   B 1 443 ? -10.815 -5.040  -50.877 1.00 44.34 ? 443 ARG   B NE  1 
ATOM   6329 C CZ  . ARG   B 1 443 ? -11.614 -4.633  -49.902 1.00 48.46 ? 443 ARG   B CZ  1 
ATOM   6330 N NH1 . ARG   B 1 443 ? -11.187 -3.814  -48.957 1.00 48.92 ? 443 ARG   B NH1 1 
ATOM   6331 N NH2 . ARG   B 1 443 ? -12.875 -5.054  -49.879 1.00 48.59 ? 443 ARG   B NH2 1 
ATOM   6332 N N   . ILE   B 1 444 ? -6.224  -7.519  -52.038 1.00 40.95 ? 444 ILE   B N   1 
ATOM   6333 C CA  . ILE   B 1 444 ? -4.983  -7.084  -52.673 1.00 42.06 ? 444 ILE   B CA  1 
ATOM   6334 C C   . ILE   B 1 444 ? -5.016  -7.390  -54.165 1.00 44.40 ? 444 ILE   B C   1 
ATOM   6335 O O   . ILE   B 1 444 ? -4.591  -6.574  -54.991 1.00 44.55 ? 444 ILE   B O   1 
ATOM   6336 C CB  . ILE   B 1 444 ? -3.770  -7.735  -51.982 1.00 41.36 ? 444 ILE   B CB  1 
ATOM   6337 C CG1 . ILE   B 1 444 ? -3.612  -7.187  -50.563 1.00 41.46 ? 444 ILE   B CG1 1 
ATOM   6338 C CG2 . ILE   B 1 444 ? -2.502  -7.502  -52.788 1.00 42.29 ? 444 ILE   B CG2 1 
ATOM   6339 C CD1 . ILE   B 1 444 ? -2.450  -7.789  -49.800 1.00 40.22 ? 444 ILE   B CD1 1 
ATOM   6340 N N   . GLY   B 1 445 ? -5.539  -8.562  -54.535 1.00 44.06 ? 445 GLY   B N   1 
ATOM   6341 C CA  . GLY   B 1 445 ? -5.613  -8.915  -55.943 1.00 44.64 ? 445 GLY   B CA  1 
ATOM   6342 C C   . GLY   B 1 445 ? -6.500  -7.977  -56.737 1.00 44.01 ? 445 GLY   B C   1 
ATOM   6343 O O   . GLY   B 1 445 ? -6.221  -7.680  -57.902 1.00 42.46 ? 445 GLY   B O   1 
ATOM   6344 N N   . ALA   B 1 446 ? -7.584  -7.502  -56.119 1.00 43.61 ? 446 ALA   B N   1 
ATOM   6345 C CA  . ALA   B 1 446 ? -8.448  -6.528  -56.777 1.00 44.66 ? 446 ALA   B CA  1 
ATOM   6346 C C   . ALA   B 1 446 ? -7.734  -5.197  -56.962 1.00 46.32 ? 446 ALA   B C   1 
ATOM   6347 O O   . ALA   B 1 446 ? -7.854  -4.563  -58.018 1.00 49.46 ? 446 ALA   B O   1 
ATOM   6348 C CB  . ALA   B 1 446 ? -9.734  -6.339  -55.973 1.00 39.87 ? 446 ALA   B CB  1 
ATOM   6349 N N   . LEU   B 1 447 ? -6.986  -4.759  -55.947 1.00 45.49 ? 447 LEU   B N   1 
ATOM   6350 C CA  . LEU   B 1 447 ? -6.252  -3.504  -56.058 1.00 47.62 ? 447 LEU   B CA  1 
ATOM   6351 C C   . LEU   B 1 447 ? -5.109  -3.607  -57.060 1.00 47.99 ? 447 LEU   B C   1 
ATOM   6352 O O   . LEU   B 1 447 ? -4.761  -2.610  -57.705 1.00 49.62 ? 447 LEU   B O   1 
ATOM   6353 C CB  . LEU   B 1 447 ? -5.726  -3.085  -54.686 1.00 44.23 ? 447 LEU   B CB  1 
ATOM   6354 C CG  . LEU   B 1 447 ? -6.792  -2.748  -53.643 1.00 44.48 ? 447 LEU   B CG  1 
ATOM   6355 C CD1 . LEU   B 1 447 ? -6.184  -2.690  -52.253 1.00 44.77 ? 447 LEU   B CD1 1 
ATOM   6356 C CD2 . LEU   B 1 447 ? -7.471  -1.427  -53.986 1.00 43.69 ? 447 LEU   B CD2 1 
ATOM   6357 N N   . VAL   B 1 448 ? -4.513  -4.792  -57.201 1.00 44.97 ? 448 VAL   B N   1 
ATOM   6358 C CA  . VAL   B 1 448 ? -3.478  -4.979  -58.212 1.00 46.32 ? 448 VAL   B CA  1 
ATOM   6359 C C   . VAL   B 1 448 ? -4.069  -4.845  -59.610 1.00 51.88 ? 448 VAL   B C   1 
ATOM   6360 O O   . VAL   B 1 448 ? -3.483  -4.198  -60.487 1.00 52.71 ? 448 VAL   B O   1 
ATOM   6361 C CB  . VAL   B 1 448 ? -2.780  -6.338  -58.016 1.00 46.16 ? 448 VAL   B CB  1 
ATOM   6362 C CG1 . VAL   B 1 448 ? -1.881  -6.652  -59.200 1.00 47.69 ? 448 VAL   B CG1 1 
ATOM   6363 C CG2 . VAL   B 1 448 ? -1.971  -6.339  -56.727 1.00 44.08 ? 448 VAL   B CG2 1 
ATOM   6364 N N   . ALA   B 1 449 ? -5.244  -5.437  -59.839 1.00 51.03 ? 449 ALA   B N   1 
ATOM   6365 C CA  . ALA   B 1 449 ? -5.883  -5.339  -61.147 1.00 50.06 ? 449 ALA   B CA  1 
ATOM   6366 C C   . ALA   B 1 449 ? -6.201  -3.891  -61.499 1.00 54.18 ? 449 ALA   B C   1 
ATOM   6367 O O   . ALA   B 1 449 ? -6.038  -3.475  -62.653 1.00 57.10 ? 449 ALA   B O   1 
ATOM   6368 C CB  . ALA   B 1 449 ? -7.153  -6.192  -61.177 1.00 43.97 ? 449 ALA   B CB  1 
ATOM   6369 N N   . GLU   B 1 450 ? -6.656  -3.109  -60.517 1.00 52.81 ? 450 GLU   B N   1 
ATOM   6370 C CA  . GLU   B 1 450 ? -6.898  -1.691  -60.755 1.00 54.79 ? 450 GLU   B CA  1 
ATOM   6371 C C   . GLU   B 1 450 ? -5.600  -0.958  -61.070 1.00 55.33 ? 450 GLU   B C   1 
ATOM   6372 O O   . GLU   B 1 450 ? -5.573  -0.062  -61.923 1.00 58.51 ? 450 GLU   B O   1 
ATOM   6373 C CB  . GLU   B 1 450 ? -7.583  -1.061  -59.542 1.00 52.26 ? 450 GLU   B CB  1 
ATOM   6374 C CG  . GLU   B 1 450 ? -8.973  -1.608  -59.236 1.00 54.13 ? 450 GLU   B CG  1 
ATOM   6375 C CD  . GLU   B 1 450 ? -9.558  -1.014  -57.972 1.00 62.18 ? 450 GLU   B CD  1 
ATOM   6376 O OE1 . GLU   B 1 450 ? -8.885  -0.167  -57.353 1.00 60.80 ? 450 GLU   B OE1 1 
ATOM   6377 O OE2 . GLU   B 1 450 ? -10.684 -1.393  -57.593 1.00 63.85 ? 450 GLU   B OE2 1 
ATOM   6378 N N   . ALA   B 1 451 ? -4.511  -1.325  -60.389 1.00 55.42 ? 451 ALA   B N   1 
ATOM   6379 C CA  . ALA   B 1 451 ? -3.236  -0.649  -60.605 1.00 56.66 ? 451 ALA   B CA  1 
ATOM   6380 C C   . ALA   B 1 451 ? -2.672  -0.934  -61.990 1.00 60.99 ? 451 ALA   B C   1 
ATOM   6381 O O   . ALA   B 1 451 ? -1.903  -0.124  -62.521 1.00 65.74 ? 451 ALA   B O   1 
ATOM   6382 C CB  . ALA   B 1 451 ? -2.232  -1.064  -59.531 1.00 52.55 ? 451 ALA   B CB  1 
ATOM   6383 N N   . LEU   B 1 452 ? -3.034  -2.066  -62.586 1.00 60.14 ? 452 LEU   B N   1 
ATOM   6384 C CA  . LEU   B 1 452 ? -2.525  -2.462  -63.891 1.00 61.35 ? 452 LEU   B CA  1 
ATOM   6385 C C   . LEU   B 1 452 ? -3.366  -1.925  -65.041 1.00 64.15 ? 452 LEU   B C   1 
ATOM   6386 O O   . LEU   B 1 452 ? -3.145  -2.321  -66.191 1.00 65.41 ? 452 LEU   B O   1 
ATOM   6387 C CB  . LEU   B 1 452 ? -2.436  -3.988  -63.982 1.00 58.41 ? 452 LEU   B CB  1 
ATOM   6388 C CG  . LEU   B 1 452 ? -1.157  -4.681  -63.502 1.00 56.42 ? 452 LEU   B CG  1 
ATOM   6389 C CD1 . LEU   B 1 452 ? -0.758  -4.259  -62.100 1.00 59.02 ? 452 LEU   B CD1 1 
ATOM   6390 C CD2 . LEU   B 1 452 ? -1.337  -6.185  -63.564 1.00 52.58 ? 452 LEU   B CD2 1 
ATOM   6391 N N   . ASP   B 1 453 ? -4.323  -1.041  -64.762 1.00 65.68 ? 453 ASP   B N   1 
ATOM   6392 C CA  . ASP   B 1 453 ? -5.158  -0.462  -65.806 1.00 69.49 ? 453 ASP   B CA  1 
ATOM   6393 C C   . ASP   B 1 453 ? -5.019  1.055   -65.826 1.00 73.75 ? 453 ASP   B C   1 
ATOM   6394 O O   . ASP   B 1 453 ? -6.019  1.778   -65.758 1.00 75.98 ? 453 ASP   B O   1 
ATOM   6395 C CB  . ASP   B 1 453 ? -6.624  -0.857  -65.607 1.00 69.07 ? 453 ASP   B CB  1 
ATOM   6396 C CG  . ASP   B 1 453 ? -6.856  -2.346  -65.777 1.00 70.77 ? 453 ASP   B CG  1 
ATOM   6397 O OD1 . ASP   B 1 453 ? -6.061  -2.999  -66.482 1.00 71.53 ? 453 ASP   B OD1 1 
ATOM   6398 O OD2 . ASP   B 1 453 ? -7.842  -2.860  -65.210 1.00 68.35 ? 453 ASP   B OD2 1 
ATOM   6399 N N   . ARG   B 1 454 ? -3.788  1.547   -65.923 1.00 75.00 ? 454 ARG   B N   1 
ATOM   6400 C CA  . ARG   B 1 454 ? -3.541  2.984   -65.939 1.00 76.70 ? 454 ARG   B CA  1 
ATOM   6401 C C   . ARG   B 1 454 ? -3.800  3.569   -67.322 1.00 83.76 ? 454 ARG   B C   1 
ATOM   6402 O O   . ARG   B 1 454 ? -2.873  3.998   -68.008 1.00 86.55 ? 454 ARG   B O   1 
ATOM   6403 C CB  . ARG   B 1 454 ? -2.107  3.290   -65.497 1.00 76.17 ? 454 ARG   B CB  1 
ATOM   6404 C CG  . ARG   B 1 454 ? -1.737  2.674   -64.160 1.00 75.35 ? 454 ARG   B CG  1 
ATOM   6405 C CD  . ARG   B 1 454 ? -0.731  3.530   -63.412 1.00 72.42 ? 454 ARG   B CD  1 
ATOM   6406 N NE  . ARG   B 1 454 ? -0.555  3.074   -62.039 1.00 75.03 ? 454 ARG   B NE  1 
ATOM   6407 C CZ  . ARG   B 1 454 ? 0.421   2.276   -61.631 1.00 69.91 ? 454 ARG   B CZ  1 
ATOM   6408 N NH1 . ARG   B 1 454 ? 1.352   1.841   -62.464 1.00 72.34 ? 454 ARG   B NH1 1 
ATOM   6409 N NH2 . ARG   B 1 454 ? 0.465   1.906   -60.354 1.00 62.39 ? 454 ARG   B NH2 1 
HETATM 6410 C C05 . A1D5H C 2 .   ? 3.316   -35.864 -25.413 1.00 57.43 ? 501 A1D5H A C05 1 
HETATM 6411 C C09 . A1D5H C 2 .   ? 7.031   -35.286 -26.263 1.00 52.95 ? 501 A1D5H A C09 1 
HETATM 6412 C C10 . A1D5H C 2 .   ? 7.558   -34.766 -27.595 1.00 50.99 ? 501 A1D5H A C10 1 
HETATM 6413 C C02 . A1D5H C 2 .   ? 1.668   -33.668 -25.755 1.00 59.35 ? 501 A1D5H A C02 1 
HETATM 6414 C C03 . A1D5H C 2 .   ? 2.614   -33.975 -26.720 1.00 59.43 ? 501 A1D5H A C03 1 
HETATM 6415 C C04 . A1D5H C 2 .   ? 3.435   -35.076 -26.549 1.00 59.17 ? 501 A1D5H A C04 1 
HETATM 6416 C C07 . A1D5H C 2 .   ? 5.612   -36.936 -25.380 1.00 55.75 ? 501 A1D5H A C07 1 
HETATM 6417 C C11 . A1D5H C 2 .   ? 8.883   -35.430 -27.957 1.00 51.87 ? 501 A1D5H A C11 1 
HETATM 6418 C C12 . A1D5H C 2 .   ? 9.417   -34.994 -29.319 1.00 55.10 ? 501 A1D5H A C12 1 
HETATM 6419 C C15 . A1D5H C 2 .   ? 2.373   -35.552 -24.450 1.00 59.68 ? 501 A1D5H A C15 1 
HETATM 6420 C C16 . A1D5H C 2 .   ? 1.548   -34.453 -24.622 1.00 58.08 ? 501 A1D5H A C16 1 
HETATM 6421 N N01 . A1D5H C 2 .   ? 0.802   -32.518 -25.932 1.00 61.60 ? 501 A1D5H A N01 1 
HETATM 6422 N N06 . A1D5H C 2 .   ? 4.172   -37.021 -25.222 1.00 54.95 ? 501 A1D5H A N06 1 
HETATM 6423 O O08 . A1D5H C 2 .   ? 6.173   -36.358 -26.521 1.00 57.33 ? 501 A1D5H A O08 1 
HETATM 6424 O O13 . A1D5H C 2 .   ? 10.681  -35.576 -29.492 1.00 50.61 ? 501 A1D5H A O13 1 
HETATM 6425 O O14 . A1D5H C 2 .   ? 6.321   -37.374 -24.538 1.00 58.11 ? 501 A1D5H A O14 1 
HETATM 6426 C C1  . GOL   D 3 .   ? 3.548   -10.755 -17.414 1.00 50.79 ? 502 GOL   A C1  1 
HETATM 6427 O O1  . GOL   D 3 .   ? 3.118   -9.611  -16.715 1.00 53.73 ? 502 GOL   A O1  1 
HETATM 6428 C C2  . GOL   D 3 .   ? 4.740   -11.374 -16.712 1.00 56.75 ? 502 GOL   A C2  1 
HETATM 6429 O O2  . GOL   D 3 .   ? 4.388   -12.666 -16.269 1.00 58.37 ? 502 GOL   A O2  1 
HETATM 6430 C C3  . GOL   D 3 .   ? 5.930   -11.420 -17.660 1.00 52.23 ? 502 GOL   A C3  1 
HETATM 6431 O O3  . GOL   D 3 .   ? 6.772   -10.328 -17.359 1.00 50.85 ? 502 GOL   A O3  1 
HETATM 6432 C C1  . GOL   E 3 .   ? -6.567  -32.066 -37.370 1.00 64.41 ? 503 GOL   A C1  1 
HETATM 6433 O O1  . GOL   E 3 .   ? -7.432  -31.174 -38.031 1.00 62.88 ? 503 GOL   A O1  1 
HETATM 6434 C C2  . GOL   E 3 .   ? -5.468  -32.495 -38.320 1.00 67.33 ? 503 GOL   A C2  1 
HETATM 6435 O O2  . GOL   E 3 .   ? -4.443  -31.526 -38.285 1.00 68.40 ? 503 GOL   A O2  1 
HETATM 6436 C C3  . GOL   E 3 .   ? -4.951  -33.869 -37.923 1.00 61.98 ? 503 GOL   A C3  1 
HETATM 6437 O O3  . GOL   E 3 .   ? -4.501  -34.519 -39.091 1.00 64.94 ? 503 GOL   A O3  1 
HETATM 6438 C C05 . A1D5H F 2 .   ? -6.616  -36.339 -18.703 1.00 52.34 ? 504 A1D5H A C05 1 
HETATM 6439 C C09 . A1D5H F 2 .   ? -5.593  -33.077 -20.048 1.00 53.41 ? 504 A1D5H A C09 1 
HETATM 6440 C C10 . A1D5H F 2 .   ? -5.375  -31.957 -21.061 1.00 51.41 ? 504 A1D5H A C10 1 
HETATM 6441 C C02 . A1D5H F 2 .   ? -6.974  -38.875 -19.711 1.00 56.80 ? 504 A1D5H A C02 1 
HETATM 6442 C C03 . A1D5H F 2 .   ? -5.841  -38.153 -20.047 1.00 53.98 ? 504 A1D5H A C03 1 
HETATM 6443 C C04 . A1D5H F 2 .   ? -5.663  -36.879 -19.547 1.00 52.01 ? 504 A1D5H A C04 1 
HETATM 6444 C C07 . A1D5H F 2 .   ? -7.329  -34.034 -18.795 1.00 47.60 ? 504 A1D5H A C07 1 
HETATM 6445 C C11 . A1D5H F 2 .   ? -4.107  -32.202 -21.878 1.00 49.29 ? 504 A1D5H A C11 1 
HETATM 6446 C C12 . A1D5H F 2 .   ? -3.962  -31.258 -23.068 1.00 49.87 ? 504 A1D5H A C12 1 
HETATM 6447 C C15 . A1D5H F 2 .   ? -7.757  -37.050 -18.373 1.00 52.33 ? 504 A1D5H A C15 1 
HETATM 6448 C C16 . A1D5H F 2 .   ? -7.932  -38.326 -18.877 1.00 53.70 ? 504 A1D5H A C16 1 
HETATM 6449 N N01 . A1D5H F 2 .   ? -7.149  -40.211 -20.244 1.00 65.46 ? 504 A1D5H A N01 1 
HETATM 6450 N N06 . A1D5H F 2 .   ? -6.441  -35.000 -18.198 1.00 52.42 ? 504 A1D5H A N06 1 
HETATM 6451 O O08 . A1D5H F 2 .   ? -6.954  -33.371 -19.970 1.00 50.86 ? 504 A1D5H A O08 1 
HETATM 6452 O O13 . A1D5H F 2 .   ? -2.922  -31.752 -23.867 1.00 52.63 ? 504 A1D5H A O13 1 
HETATM 6453 O O14 . A1D5H F 2 .   ? -8.389  -33.837 -18.313 1.00 47.79 ? 504 A1D5H A O14 1 
HETATM 6454 C C05 . A1D5H G 2 .   ? -1.782  -32.707 -57.872 1.00 52.74 ? 501 A1D5H B C05 1 
HETATM 6455 C C09 . A1D5H G 2 .   ? -5.094  -32.099 -56.497 1.00 51.03 ? 501 A1D5H B C09 1 
HETATM 6456 C C10 . A1D5H G 2 .   ? -6.245  -31.835 -55.528 1.00 49.65 ? 501 A1D5H B C10 1 
HETATM 6457 C C02 . A1D5H G 2 .   ? 0.519   -33.891 -56.930 1.00 55.18 ? 501 A1D5H B C02 1 
HETATM 6458 C C03 . A1D5H G 2 .   ? -0.715  -34.411 -56.587 1.00 52.26 ? 501 A1D5H B C03 1 
HETATM 6459 C C04 . A1D5H G 2 .   ? -1.870  -33.816 -57.053 1.00 49.47 ? 501 A1D5H B C04 1 
HETATM 6460 C C07 . A1D5H G 2 .   ? -3.374  -30.918 -57.567 1.00 47.37 ? 501 A1D5H B C07 1 
HETATM 6461 C C11 . A1D5H G 2 .   ? -6.569  -33.060 -54.673 1.00 47.49 ? 501 A1D5H B C11 1 
HETATM 6462 C C12 . A1D5H G 2 .   ? -7.541  -32.735 -53.541 1.00 46.53 ? 501 A1D5H B C12 1 
HETATM 6463 C C15 . A1D5H G 2 .   ? -0.551  -32.171 -58.211 1.00 52.57 ? 501 A1D5H B C15 1 
HETATM 6464 C C16 . A1D5H G 2 .   ? 0.606   -32.771 -57.743 1.00 52.77 ? 501 A1D5H B C16 1 
HETATM 6465 N N01 . A1D5H G 2 .   ? 1.720   -34.530 -56.429 1.00 59.25 ? 501 A1D5H B N01 1 
HETATM 6466 N N06 . A1D5H G 2 .   ? -2.995  -32.080 -58.335 1.00 51.62 ? 501 A1D5H B N06 1 
HETATM 6467 O O08 . A1D5H G 2 .   ? -4.169  -31.055 -56.423 1.00 52.30 ? 501 A1D5H B O08 1 
HETATM 6468 O O13 . A1D5H G 2 .   ? -7.637  -33.862 -52.713 1.00 48.75 ? 501 A1D5H B O13 1 
HETATM 6469 O O14 . A1D5H G 2 .   ? -2.973  -29.855 -57.891 1.00 45.98 ? 501 A1D5H B O14 1 
HETATM 6470 O O   . HOH   H 4 .   ? -23.374 -29.099 -36.434 1.00 45.12 ? 601 HOH   A O   1 
HETATM 6471 O O   . HOH   H 4 .   ? -11.241 -48.355 -4.661  1.00 53.97 ? 602 HOH   A O   1 
HETATM 6472 O O   . HOH   H 4 .   ? -33.288 -39.683 -37.781 1.00 59.79 ? 603 HOH   A O   1 
HETATM 6473 O O   . HOH   H 4 .   ? -28.882 -32.134 -6.402  1.00 48.59 ? 604 HOH   A O   1 
HETATM 6474 O O   . HOH   H 4 .   ? 8.864   -30.828 -30.803 1.00 50.18 ? 605 HOH   A O   1 
HETATM 6475 O O   . HOH   H 4 .   ? -18.376 -44.613 -13.279 1.00 42.97 ? 606 HOH   A O   1 
HETATM 6476 O O   . HOH   H 4 .   ? -7.216  -30.539 -40.326 1.00 58.81 ? 607 HOH   A O   1 
HETATM 6477 O O   . HOH   H 4 .   ? -23.295 -36.118 -4.819  1.00 54.59 ? 608 HOH   A O   1 
HETATM 6478 O O   . HOH   H 4 .   ? -17.837 -10.101 -15.987 1.00 44.95 ? 609 HOH   A O   1 
HETATM 6479 O O   . HOH   H 4 .   ? -0.088  -36.098 -10.655 1.00 38.65 ? 610 HOH   A O   1 
HETATM 6480 O O   . HOH   H 4 .   ? -14.751 -13.798 -13.508 1.00 38.98 ? 611 HOH   A O   1 
HETATM 6481 O O   . HOH   H 4 .   ? -25.942 -43.931 -16.336 1.00 50.39 ? 612 HOH   A O   1 
HETATM 6482 O O   . HOH   H 4 .   ? -12.689 -49.421 -9.816  1.00 49.86 ? 613 HOH   A O   1 
HETATM 6483 O O   . HOH   H 4 .   ? 2.739   -46.977 -36.513 1.00 47.15 ? 614 HOH   A O   1 
HETATM 6484 O O   . HOH   H 4 .   ? -28.109 -43.284 -29.428 1.00 52.82 ? 615 HOH   A O   1 
HETATM 6485 O O   . HOH   H 4 .   ? 18.296  -30.086 -14.047 1.00 46.64 ? 616 HOH   A O   1 
HETATM 6486 O O   . HOH   H 4 .   ? -33.024 -38.234 -20.812 1.00 41.69 ? 617 HOH   A O   1 
HETATM 6487 O O   . HOH   H 4 .   ? -3.143  -37.112 -38.239 1.00 48.01 ? 618 HOH   A O   1 
HETATM 6488 O O   . HOH   H 4 .   ? -21.196 -39.796 -4.849  1.00 56.03 ? 619 HOH   A O   1 
HETATM 6489 O O   . HOH   H 4 .   ? -16.288 -39.583 -42.672 1.00 43.55 ? 620 HOH   A O   1 
HETATM 6490 O O   . HOH   H 4 .   ? -1.806  2.844   -7.530  1.00 54.96 ? 621 HOH   A O   1 
HETATM 6491 O O   . HOH   H 4 .   ? -21.912 -34.240 -10.631 1.00 37.98 ? 622 HOH   A O   1 
HETATM 6492 O O   . HOH   H 4 .   ? -10.377 -24.600 -29.397 1.00 37.23 ? 623 HOH   A O   1 
HETATM 6493 O O   . HOH   H 4 .   ? -26.129 -23.148 -31.924 1.00 48.63 ? 624 HOH   A O   1 
HETATM 6494 O O   . HOH   H 4 .   ? -13.353 -4.827  -20.998 1.00 46.46 ? 625 HOH   A O   1 
HETATM 6495 O O   . HOH   H 4 .   ? -2.139  -38.327 -10.485 1.00 50.51 ? 626 HOH   A O   1 
HETATM 6496 O O   . HOH   H 4 .   ? -2.823  -50.426 -15.755 1.00 60.84 ? 627 HOH   A O   1 
HETATM 6497 O O   . HOH   H 4 .   ? -5.935  -18.951 -31.418 1.00 38.38 ? 628 HOH   A O   1 
HETATM 6498 O O   . HOH   H 4 .   ? -22.344 -13.851 -28.281 1.00 40.58 ? 629 HOH   A O   1 
HETATM 6499 O O   . HOH   H 4 .   ? -6.457  -31.550 -6.539  1.00 42.46 ? 630 HOH   A O   1 
HETATM 6500 O O   . HOH   H 4 .   ? 11.145  -33.219 -23.494 1.00 44.68 ? 631 HOH   A O   1 
HETATM 6501 O O   . HOH   H 4 .   ? -11.802 -8.210  -5.992  1.00 44.15 ? 632 HOH   A O   1 
HETATM 6502 O O   . HOH   H 4 .   ? -11.497 -36.510 -37.984 1.00 42.57 ? 633 HOH   A O   1 
HETATM 6503 O O   . HOH   H 4 .   ? -26.318 -25.664 -31.112 1.00 45.08 ? 634 HOH   A O   1 
HETATM 6504 O O   . HOH   H 4 .   ? 8.995   -11.274 -11.022 1.00 51.64 ? 635 HOH   A O   1 
HETATM 6505 O O   . HOH   H 4 .   ? 9.079   -23.650 -24.400 1.00 46.56 ? 636 HOH   A O   1 
HETATM 6506 O O   . HOH   H 4 .   ? -26.908 -17.251 -31.907 1.00 47.22 ? 637 HOH   A O   1 
HETATM 6507 O O   . HOH   H 4 .   ? -33.136 -16.724 -18.345 1.00 53.31 ? 638 HOH   A O   1 
HETATM 6508 O O   . HOH   H 4 .   ? -28.997 -42.198 -33.909 1.00 53.81 ? 639 HOH   A O   1 
HETATM 6509 O O   . HOH   H 4 .   ? -6.976  -27.152 5.598   1.00 47.74 ? 640 HOH   A O   1 
HETATM 6510 O O   . HOH   H 4 .   ? -11.290 -31.511 -25.166 1.00 44.73 ? 641 HOH   A O   1 
HETATM 6511 O O   . HOH   H 4 .   ? 1.940   -3.852  -18.959 1.00 51.30 ? 642 HOH   A O   1 
HETATM 6512 O O   . HOH   H 4 .   ? -22.158 -39.507 -42.618 1.00 45.74 ? 643 HOH   A O   1 
HETATM 6513 O O   . HOH   H 4 .   ? -27.901 -26.414 -33.581 1.00 42.06 ? 644 HOH   A O   1 
HETATM 6514 O O   . HOH   H 4 .   ? -10.268 -13.781 -32.532 1.00 45.74 ? 645 HOH   A O   1 
HETATM 6515 O O   . HOH   H 4 .   ? -9.291  -34.671 -35.189 1.00 50.87 ? 646 HOH   A O   1 
HETATM 6516 O O   . HOH   H 4 .   ? -8.087  -25.007 -29.075 1.00 39.61 ? 647 HOH   A O   1 
HETATM 6517 O O   . HOH   H 4 .   ? -16.568 -42.980 -33.966 1.00 46.68 ? 648 HOH   A O   1 
HETATM 6518 O O   . HOH   H 4 .   ? 3.099   1.865   -20.488 1.00 51.26 ? 649 HOH   A O   1 
HETATM 6519 O O   . HOH   H 4 .   ? -11.165 -9.832  -8.520  1.00 48.70 ? 650 HOH   A O   1 
HETATM 6520 O O   . HOH   H 4 .   ? -22.247 -32.535 -13.152 1.00 37.50 ? 651 HOH   A O   1 
HETATM 6521 O O   . HOH   H 4 .   ? -32.315 -40.611 -24.029 1.00 45.78 ? 652 HOH   A O   1 
HETATM 6522 O O   . HOH   H 4 .   ? 9.184   -26.443 -24.475 1.00 42.62 ? 653 HOH   A O   1 
HETATM 6523 O O   . HOH   H 4 .   ? -10.241 2.857   -4.232  1.00 63.02 ? 654 HOH   A O   1 
HETATM 6524 O O   . HOH   H 4 .   ? -26.474 -33.144 -41.033 1.00 47.70 ? 655 HOH   A O   1 
HETATM 6525 O O   . HOH   H 4 .   ? -17.683 -16.665 -0.921  1.00 64.12 ? 656 HOH   A O   1 
HETATM 6526 O O   . HOH   H 4 .   ? -3.159  -40.069 -13.163 1.00 50.19 ? 657 HOH   A O   1 
HETATM 6527 O O   . HOH   H 4 .   ? 0.035   -46.794 -5.589  1.00 57.39 ? 658 HOH   A O   1 
HETATM 6528 O O   . HOH   H 4 .   ? 6.743   -20.705 -18.889 1.00 42.43 ? 659 HOH   A O   1 
HETATM 6529 O O   . HOH   H 4 .   ? 7.092   -13.570 -7.345  1.00 50.70 ? 660 HOH   A O   1 
HETATM 6530 O O   . HOH   H 4 .   ? -10.540 -12.029 -8.118  1.00 46.20 ? 661 HOH   A O   1 
HETATM 6531 O O   . HOH   H 4 .   ? -11.810 -44.711 -43.859 1.00 41.07 ? 662 HOH   A O   1 
HETATM 6532 O O   . HOH   H 4 .   ? -7.915  -27.407 -30.463 1.00 38.65 ? 663 HOH   A O   1 
HETATM 6533 O O   . HOH   H 4 .   ? -18.400 -10.434 -22.795 1.00 44.31 ? 664 HOH   A O   1 
HETATM 6534 O O   . HOH   H 4 .   ? -9.182  -1.040  -17.938 1.00 48.30 ? 665 HOH   A O   1 
HETATM 6535 O O   . HOH   H 4 .   ? -12.763 -36.523 2.043   1.00 51.01 ? 666 HOH   A O   1 
HETATM 6536 O O   . HOH   H 4 .   ? -17.305 -15.053 -37.554 1.00 44.51 ? 667 HOH   A O   1 
HETATM 6537 O O   . HOH   H 4 .   ? 0.339   -36.499 -26.741 1.00 57.13 ? 668 HOH   A O   1 
HETATM 6538 O O   . HOH   H 4 .   ? 11.068  -37.829 -27.921 1.00 53.47 ? 669 HOH   A O   1 
HETATM 6539 O O   . HOH   H 4 .   ? -7.597  -7.307  -7.870  1.00 44.77 ? 670 HOH   A O   1 
HETATM 6540 O O   . HOH   H 4 .   ? -12.301 -31.469 -29.053 1.00 41.39 ? 671 HOH   A O   1 
HETATM 6541 O O   . HOH   H 4 .   ? -35.174 -35.741 -32.187 1.00 47.70 ? 672 HOH   A O   1 
HETATM 6542 O O   . HOH   H 4 .   ? -1.808  -20.631 -27.119 1.00 40.55 ? 673 HOH   A O   1 
HETATM 6543 O O   . HOH   H 4 .   ? -4.264  -25.138 -13.538 1.00 36.58 ? 674 HOH   A O   1 
HETATM 6544 O O   . HOH   H 4 .   ? 2.401   -47.092 -40.510 1.00 47.79 ? 675 HOH   A O   1 
HETATM 6545 O O   . HOH   H 4 .   ? 11.168  -30.009 -8.457  1.00 47.03 ? 676 HOH   A O   1 
HETATM 6546 O O   . HOH   H 4 .   ? -19.390 -18.894 -31.690 1.00 44.87 ? 677 HOH   A O   1 
HETATM 6547 O O   . HOH   H 4 .   ? -21.780 -26.421 -36.656 1.00 48.36 ? 678 HOH   A O   1 
HETATM 6548 O O   . HOH   H 4 .   ? 4.454   -45.608 -34.476 1.00 48.27 ? 679 HOH   A O   1 
HETATM 6549 O O   . HOH   H 4 .   ? 4.628   -39.790 -24.836 1.00 49.23 ? 680 HOH   A O   1 
HETATM 6550 O O   . HOH   H 4 .   ? 6.979   -25.781 -22.723 1.00 45.83 ? 681 HOH   A O   1 
HETATM 6551 O O   . HOH   H 4 .   ? -25.929 -28.983 -37.284 1.00 47.07 ? 682 HOH   A O   1 
HETATM 6552 O O   . HOH   H 4 .   ? -18.143 -43.108 -36.183 1.00 45.89 ? 683 HOH   A O   1 
HETATM 6553 O O   . HOH   H 4 .   ? -5.849  -34.296 -5.430  1.00 40.26 ? 684 HOH   A O   1 
HETATM 6554 O O   . HOH   H 4 .   ? -5.055  -8.940  -28.194 1.00 49.77 ? 685 HOH   A O   1 
HETATM 6555 O O   . HOH   H 4 .   ? -5.133  -16.170 -35.448 1.00 44.60 ? 686 HOH   A O   1 
HETATM 6556 O O   . HOH   H 4 .   ? -10.997 -22.516 1.283   1.00 51.45 ? 687 HOH   A O   1 
HETATM 6557 O O   . HOH   H 4 .   ? -1.757  -29.341 0.181   1.00 41.69 ? 688 HOH   A O   1 
HETATM 6558 O O   . HOH   H 4 .   ? -5.272  3.986   -12.930 1.00 55.71 ? 689 HOH   A O   1 
HETATM 6559 O O   . HOH   H 4 .   ? -9.085  -37.083 1.753   1.00 46.95 ? 690 HOH   A O   1 
HETATM 6560 O O   . HOH   H 4 .   ? -6.676  4.930   -3.880  1.00 62.14 ? 691 HOH   A O   1 
HETATM 6561 O O   . HOH   H 4 .   ? -19.201 -33.996 -23.641 1.00 41.48 ? 692 HOH   A O   1 
HETATM 6562 O O   . HOH   H 4 .   ? -6.111  -27.211 -32.462 1.00 40.11 ? 693 HOH   A O   1 
HETATM 6563 O O   . HOH   H 4 .   ? -24.755 -50.552 -19.261 1.00 54.94 ? 694 HOH   A O   1 
HETATM 6564 O O   . HOH   H 4 .   ? -2.121  -46.292 -3.815  1.00 49.74 ? 695 HOH   A O   1 
HETATM 6565 O O   . HOH   H 4 .   ? -2.608  -34.922 -35.938 1.00 62.49 ? 696 HOH   A O   1 
HETATM 6566 O O   . HOH   H 4 .   ? -35.043 -16.619 -20.980 1.00 49.17 ? 697 HOH   A O   1 
HETATM 6567 O O   . HOH   H 4 .   ? -9.203  -8.492  -10.231 1.00 43.96 ? 698 HOH   A O   1 
HETATM 6568 O O   . HOH   H 4 .   ? -10.340 -9.050  -1.762  1.00 58.26 ? 699 HOH   A O   1 
HETATM 6569 O O   . HOH   H 4 .   ? -9.990  -33.947 -32.824 1.00 46.66 ? 700 HOH   A O   1 
HETATM 6570 O O   . HOH   H 4 .   ? 3.580   -15.769 -29.126 1.00 50.06 ? 701 HOH   A O   1 
HETATM 6571 O O   . HOH   H 4 .   ? -18.831 -9.008  -8.235  1.00 52.69 ? 702 HOH   A O   1 
HETATM 6572 O O   . HOH   H 4 .   ? 8.081   -36.621 -12.272 1.00 41.20 ? 703 HOH   A O   1 
HETATM 6573 O O   . HOH   H 4 .   ? -2.668  -50.828 -37.147 1.00 42.39 ? 704 HOH   A O   1 
HETATM 6574 O O   . HOH   H 4 .   ? -7.168  3.146   -26.624 1.00 50.96 ? 705 HOH   A O   1 
HETATM 6575 O O   . HOH   H 4 .   ? -17.440 -30.875 -6.462  1.00 37.31 ? 706 HOH   A O   1 
HETATM 6576 O O   . HOH   H 4 .   ? -37.830 -35.301 -14.144 1.00 56.31 ? 707 HOH   A O   1 
HETATM 6577 O O   . HOH   H 4 .   ? -21.843 -29.843 -34.502 1.00 39.65 ? 708 HOH   A O   1 
HETATM 6578 O O   . HOH   H 4 .   ? -16.983 -35.119 -43.365 1.00 39.65 ? 709 HOH   A O   1 
HETATM 6579 O O   . HOH   H 4 .   ? 4.386   -25.008 -3.783  1.00 47.90 ? 710 HOH   A O   1 
HETATM 6580 O O   . HOH   H 4 .   ? -26.398 -44.131 -26.996 1.00 48.65 ? 711 HOH   A O   1 
HETATM 6581 O O   . HOH   H 4 .   ? -28.467 -41.330 -22.840 1.00 48.83 ? 712 HOH   A O   1 
HETATM 6582 O O   . HOH   H 4 .   ? -9.700  -0.309  -20.157 1.00 45.67 ? 713 HOH   A O   1 
HETATM 6583 O O   . HOH   H 4 .   ? 10.344  -27.827 -7.353  1.00 48.06 ? 714 HOH   A O   1 
HETATM 6584 O O   . HOH   H 4 .   ? -7.907  -39.251 0.920   1.00 50.01 ? 715 HOH   A O   1 
HETATM 6585 O O   . HOH   H 4 .   ? -10.607 -47.455 -38.347 1.00 49.50 ? 716 HOH   A O   1 
HETATM 6586 O O   . HOH   H 4 .   ? -19.359 -10.344 -0.258  1.00 51.75 ? 717 HOH   A O   1 
HETATM 6587 O O   . HOH   H 4 .   ? 8.094   -38.611 -27.105 1.00 56.31 ? 718 HOH   A O   1 
HETATM 6588 O O   . HOH   H 4 .   ? -14.754 -3.337  -18.721 1.00 47.43 ? 719 HOH   A O   1 
HETATM 6589 O O   . HOH   H 4 .   ? -16.423 -40.313 -5.265  1.00 46.77 ? 720 HOH   A O   1 
HETATM 6590 O O   . HOH   H 4 .   ? -29.905 -11.065 -29.444 1.00 58.34 ? 721 HOH   A O   1 
HETATM 6591 O O   . HOH   H 4 .   ? -22.558 -21.746 -38.660 1.00 56.08 ? 722 HOH   A O   1 
HETATM 6592 O O   . HOH   H 4 .   ? -28.097 -12.819 -20.029 1.00 57.14 ? 723 HOH   A O   1 
HETATM 6593 O O   . HOH   H 4 .   ? 0.717   -46.156 -3.511  1.00 58.12 ? 724 HOH   A O   1 
HETATM 6594 O O   . HOH   H 4 .   ? -1.887  -30.887 -36.591 1.00 55.17 ? 725 HOH   A O   1 
HETATM 6595 O O   . HOH   H 4 .   ? -1.734  -34.303 -22.481 1.00 54.79 ? 726 HOH   A O   1 
HETATM 6596 O O   . HOH   H 4 .   ? -2.774  4.995   -6.096  1.00 62.58 ? 727 HOH   A O   1 
HETATM 6597 O O   . HOH   H 4 .   ? -27.500 -27.057 -36.864 1.00 53.45 ? 728 HOH   A O   1 
HETATM 6598 O O   . HOH   H 4 .   ? -7.245  -43.272 -19.427 1.00 50.32 ? 729 HOH   A O   1 
HETATM 6599 O O   . HOH   H 4 .   ? 6.203   -47.985 -31.194 1.00 54.35 ? 730 HOH   A O   1 
HETATM 6600 O O   . HOH   H 4 .   ? -16.752 -11.952 -9.988  1.00 46.27 ? 731 HOH   A O   1 
HETATM 6601 O O   . HOH   H 4 .   ? 9.036   -12.502 -7.890  1.00 47.74 ? 732 HOH   A O   1 
HETATM 6602 O O   . HOH   H 4 .   ? -17.360 -10.546 -25.134 1.00 51.18 ? 733 HOH   A O   1 
HETATM 6603 O O   . HOH   H 4 .   ? -21.677 -20.887 -36.097 1.00 51.08 ? 734 HOH   A O   1 
HETATM 6604 O O   . HOH   H 4 .   ? -2.181  -35.912 -32.446 1.00 52.57 ? 735 HOH   A O   1 
HETATM 6605 O O   . HOH   H 4 .   ? 16.940  -33.298 -15.489 1.00 58.06 ? 736 HOH   A O   1 
HETATM 6606 O O   . HOH   H 4 .   ? 11.687  -2.603  -14.394 1.00 59.54 ? 737 HOH   A O   1 
HETATM 6607 O O   . HOH   H 4 .   ? 1.622   -24.504 2.463   1.00 53.59 ? 738 HOH   A O   1 
HETATM 6608 O O   . HOH   H 4 .   ? 12.483  -28.945 -31.902 1.00 56.95 ? 739 HOH   A O   1 
HETATM 6609 O O   . HOH   H 4 .   ? 4.260   -35.578 -5.313  1.00 46.64 ? 740 HOH   A O   1 
HETATM 6610 O O   . HOH   H 4 .   ? 12.302  -26.900 -27.643 1.00 48.65 ? 741 HOH   A O   1 
HETATM 6611 O O   . HOH   H 4 .   ? -23.841 -47.972 -16.461 1.00 54.52 ? 742 HOH   A O   1 
HETATM 6612 O O   . HOH   H 4 .   ? 2.645   -36.143 -7.231  1.00 44.51 ? 743 HOH   A O   1 
HETATM 6613 O O   . HOH   H 4 .   ? -21.702 -12.109 -16.606 1.00 43.07 ? 744 HOH   A O   1 
HETATM 6614 O O   . HOH   H 4 .   ? -22.860 -18.720 -10.960 1.00 51.74 ? 745 HOH   A O   1 
HETATM 6615 O O   . HOH   H 4 .   ? -11.676 -27.845 5.013   1.00 54.33 ? 746 HOH   A O   1 
HETATM 6616 O O   . HOH   H 4 .   ? -3.930  -17.651 -33.448 1.00 40.82 ? 747 HOH   A O   1 
HETATM 6617 O O   . HOH   H 4 .   ? -4.586  -42.474 -19.482 1.00 56.40 ? 748 HOH   A O   1 
HETATM 6618 O O   . HOH   H 4 .   ? -0.895  -13.016 -30.976 1.00 46.29 ? 749 HOH   A O   1 
HETATM 6619 O O   . HOH   H 4 .   ? 1.730   7.892   -17.542 1.00 57.31 ? 750 HOH   A O   1 
HETATM 6620 O O   . HOH   H 4 .   ? -14.202 -44.980 -3.388  1.00 57.18 ? 751 HOH   A O   1 
HETATM 6621 O O   . HOH   H 4 .   ? 0.847   -35.380 -28.902 1.00 58.07 ? 752 HOH   A O   1 
HETATM 6622 O O   . HOH   H 4 .   ? 2.490   -15.389 -31.241 1.00 44.64 ? 753 HOH   A O   1 
HETATM 6623 O O   . HOH   H 4 .   ? -13.969 -40.911 -3.426  1.00 52.02 ? 754 HOH   A O   1 
HETATM 6624 O O   . HOH   H 4 .   ? 16.070  -33.003 -19.918 1.00 59.68 ? 755 HOH   A O   1 
HETATM 6625 O O   . HOH   H 4 .   ? 2.156   -36.824 -21.223 1.00 55.26 ? 756 HOH   A O   1 
HETATM 6626 O O   . HOH   H 4 .   ? 10.267  -24.308 -28.166 1.00 46.75 ? 757 HOH   A O   1 
HETATM 6627 O O   . HOH   H 4 .   ? -1.084  -10.886 -30.065 1.00 37.59 ? 758 HOH   A O   1 
HETATM 6628 O O   . HOH   H 4 .   ? -2.322  -22.853 -35.264 1.00 50.00 ? 759 HOH   A O   1 
HETATM 6629 O O   . HOH   H 4 .   ? -34.552 -21.700 -31.923 1.00 57.21 ? 760 HOH   A O   1 
HETATM 6630 O O   . HOH   H 4 .   ? 13.920  -37.261 -12.045 1.00 49.72 ? 761 HOH   A O   1 
HETATM 6631 O O   . HOH   H 4 .   ? -22.204 -13.015 -23.288 1.00 42.85 ? 762 HOH   A O   1 
HETATM 6632 O O   . HOH   H 4 .   ? 7.356   -24.678 -4.781  1.00 48.51 ? 763 HOH   A O   1 
HETATM 6633 O O   . HOH   H 4 .   ? -15.099 -48.976 -36.422 1.00 60.63 ? 764 HOH   A O   1 
HETATM 6634 O O   . HOH   H 4 .   ? 15.671  -34.697 -12.865 1.00 48.17 ? 765 HOH   A O   1 
HETATM 6635 O O   . HOH   H 4 .   ? 4.440   -8.849  1.958   1.00 66.21 ? 766 HOH   A O   1 
HETATM 6636 O O   . HOH   H 4 .   ? -19.896 -46.994 -14.140 1.00 48.58 ? 767 HOH   A O   1 
HETATM 6637 O O   . HOH   H 4 .   ? 12.787  -27.714 -29.804 1.00 51.67 ? 768 HOH   A O   1 
HETATM 6638 O O   . HOH   H 4 .   ? -25.104 -21.024 -7.787  1.00 58.71 ? 769 HOH   A O   1 
HETATM 6639 O O   . HOH   H 4 .   ? -12.680 -34.535 -38.040 1.00 46.64 ? 770 HOH   A O   1 
HETATM 6640 O O   . HOH   H 4 .   ? -18.763 -13.070 -37.594 1.00 48.97 ? 771 HOH   A O   1 
HETATM 6641 O O   . HOH   H 4 .   ? -11.325 -21.873 -37.819 1.00 55.16 ? 772 HOH   A O   1 
HETATM 6642 O O   . HOH   H 4 .   ? -34.509 -12.199 -10.291 1.00 68.20 ? 773 HOH   A O   1 
HETATM 6643 O O   . HOH   H 4 .   ? -13.712 -7.725  -28.278 1.00 59.11 ? 774 HOH   A O   1 
HETATM 6644 O O   . HOH   H 4 .   ? -15.606 -46.132 -1.988  1.00 54.00 ? 775 HOH   A O   1 
HETATM 6645 O O   . HOH   H 4 .   ? -2.632  -9.174  -30.434 1.00 44.79 ? 776 HOH   A O   1 
HETATM 6646 O O   . HOH   H 4 .   ? 7.171   -42.106 -23.974 1.00 63.14 ? 777 HOH   A O   1 
HETATM 6647 O O   . HOH   H 4 .   ? -22.764 -20.213 -8.568  1.00 47.20 ? 778 HOH   A O   1 
HETATM 6648 O O   . HOH   H 4 .   ? -34.358 -23.625 -37.722 1.00 56.20 ? 779 HOH   A O   1 
HETATM 6649 O O   . HOH   H 4 .   ? -5.000  6.950   -11.243 1.00 45.15 ? 780 HOH   A O   1 
HETATM 6650 O O   . HOH   H 4 .   ? -4.231  9.323   -11.380 1.00 50.74 ? 781 HOH   A O   1 
HETATM 6651 O O   . HOH   I 4 .   ? -31.037 -33.192 -65.228 1.00 47.95 ? 601 HOH   B O   1 
HETATM 6652 O O   . HOH   I 4 .   ? 6.413   -43.800 -71.313 1.00 55.51 ? 602 HOH   B O   1 
HETATM 6653 O O   . HOH   I 4 .   ? 10.425  -16.571 -40.241 1.00 52.30 ? 603 HOH   B O   1 
HETATM 6654 O O   . HOH   I 4 .   ? 18.721  -25.827 -47.226 1.00 53.19 ? 604 HOH   B O   1 
HETATM 6655 O O   . HOH   I 4 .   ? 8.026   -19.593 -33.431 1.00 51.45 ? 605 HOH   B O   1 
HETATM 6656 O O   . HOH   I 4 .   ? 3.039   -23.828 -33.373 1.00 46.57 ? 606 HOH   B O   1 
HETATM 6657 O O   . HOH   I 4 .   ? -18.469 -9.953  -59.579 1.00 44.87 ? 607 HOH   B O   1 
HETATM 6658 O O   . HOH   I 4 .   ? -18.155 -9.785  -72.093 1.00 47.44 ? 608 HOH   B O   1 
HETATM 6659 O O   . HOH   I 4 .   ? 4.196   -18.629 -65.579 1.00 44.24 ? 609 HOH   B O   1 
HETATM 6660 O O   . HOH   I 4 .   ? -16.894 -12.157 -42.410 1.00 50.23 ? 610 HOH   B O   1 
HETATM 6661 O O   . HOH   I 4 .   ? -14.431 -43.850 -45.626 1.00 46.29 ? 611 HOH   B O   1 
HETATM 6662 O O   . HOH   I 4 .   ? -26.735 -18.150 -74.352 1.00 48.71 ? 612 HOH   B O   1 
HETATM 6663 O O   . HOH   I 4 .   ? -43.907 -17.439 -56.175 1.00 58.69 ? 613 HOH   B O   1 
HETATM 6664 O O   . HOH   I 4 .   ? -19.600 -13.518 -74.933 1.00 50.96 ? 614 HOH   B O   1 
HETATM 6665 O O   . HOH   I 4 .   ? -25.579 -11.068 -54.906 1.00 42.07 ? 615 HOH   B O   1 
HETATM 6666 O O   . HOH   I 4 .   ? -5.329  -0.314  -56.946 1.00 46.78 ? 616 HOH   B O   1 
HETATM 6667 O O   . HOH   I 4 .   ? -28.094 -33.249 -50.398 1.00 46.61 ? 617 HOH   B O   1 
HETATM 6668 O O   . HOH   I 4 .   ? 5.875   -7.379  -68.038 1.00 59.99 ? 618 HOH   B O   1 
HETATM 6669 O O   . HOH   I 4 .   ? -10.574 0.030   -44.515 1.00 52.18 ? 619 HOH   B O   1 
HETATM 6670 O O   . HOH   I 4 .   ? -17.010 -14.503 -62.210 1.00 43.36 ? 620 HOH   B O   1 
HETATM 6671 O O   . HOH   I 4 .   ? -34.107 -23.794 -57.227 1.00 51.80 ? 621 HOH   B O   1 
HETATM 6672 O O   . HOH   I 4 .   ? -10.026 -24.159 -46.509 1.00 38.53 ? 622 HOH   B O   1 
HETATM 6673 O O   . HOH   I 4 .   ? -2.498  -15.100 -39.447 1.00 41.55 ? 623 HOH   B O   1 
HETATM 6674 O O   . HOH   I 4 .   ? -26.654 -39.400 -62.454 1.00 48.24 ? 624 HOH   B O   1 
HETATM 6675 O O   . HOH   I 4 .   ? -25.632 -31.365 -74.108 1.00 46.59 ? 625 HOH   B O   1 
HETATM 6676 O O   . HOH   I 4 .   ? 9.981   -0.695  -52.462 1.00 48.19 ? 626 HOH   B O   1 
HETATM 6677 O O   . HOH   I 4 .   ? -17.798 -31.578 -72.744 1.00 44.35 ? 627 HOH   B O   1 
HETATM 6678 O O   . HOH   I 4 .   ? -3.538  -26.721 -50.855 1.00 41.26 ? 628 HOH   B O   1 
HETATM 6679 O O   . HOH   I 4 .   ? 15.172  -18.394 -46.936 1.00 51.75 ? 629 HOH   B O   1 
HETATM 6680 O O   . HOH   I 4 .   ? -31.137 -13.187 -58.300 1.00 49.16 ? 630 HOH   B O   1 
HETATM 6681 O O   . HOH   I 4 .   ? -17.926 -29.222 -49.131 1.00 44.07 ? 631 HOH   B O   1 
HETATM 6682 O O   . HOH   I 4 .   ? -10.359 -28.959 -79.370 1.00 44.95 ? 632 HOH   B O   1 
HETATM 6683 O O   . HOH   I 4 .   ? -6.078  -30.456 -69.967 1.00 45.99 ? 633 HOH   B O   1 
HETATM 6684 O O   . HOH   I 4 .   ? -4.386  -37.919 -63.180 1.00 46.75 ? 634 HOH   B O   1 
HETATM 6685 O O   . HOH   I 4 .   ? -9.771  -29.210 -43.613 1.00 45.84 ? 635 HOH   B O   1 
HETATM 6686 O O   . HOH   I 4 .   ? -33.876 -29.721 -59.700 1.00 52.26 ? 636 HOH   B O   1 
HETATM 6687 O O   . HOH   I 4 .   ? -22.004 -36.040 -57.323 1.00 36.92 ? 637 HOH   B O   1 
HETATM 6688 O O   . HOH   I 4 .   ? -25.722 -26.538 -45.914 1.00 48.64 ? 638 HOH   B O   1 
HETATM 6689 O O   . HOH   I 4 .   ? 9.212   -22.335 -33.718 1.00 47.65 ? 639 HOH   B O   1 
HETATM 6690 O O   . HOH   I 4 .   ? 13.651  -31.951 -45.581 1.00 55.46 ? 640 HOH   B O   1 
HETATM 6691 O O   . HOH   I 4 .   ? -3.568  -14.202 -66.942 1.00 48.21 ? 641 HOH   B O   1 
HETATM 6692 O O   . HOH   I 4 .   ? -3.068  -37.108 -66.730 1.00 52.14 ? 642 HOH   B O   1 
HETATM 6693 O O   . HOH   I 4 .   ? 14.245  -13.870 -61.056 1.00 51.97 ? 643 HOH   B O   1 
HETATM 6694 O O   . HOH   I 4 .   ? -16.963 -35.603 -72.427 1.00 43.01 ? 644 HOH   B O   1 
HETATM 6695 O O   . HOH   I 4 .   ? -10.272 -4.723  -59.079 1.00 48.63 ? 645 HOH   B O   1 
HETATM 6696 O O   . HOH   I 4 .   ? -18.243 -9.534  -53.266 1.00 41.77 ? 646 HOH   B O   1 
HETATM 6697 O O   . HOH   I 4 .   ? -20.798 -47.282 -54.339 1.00 52.04 ? 647 HOH   B O   1 
HETATM 6698 O O   . HOH   I 4 .   ? -17.211 -24.882 -44.637 1.00 40.00 ? 648 HOH   B O   1 
HETATM 6699 O O   . HOH   I 4 .   ? -3.952  -31.769 -71.096 1.00 46.39 ? 649 HOH   B O   1 
HETATM 6700 O O   . HOH   I 4 .   ? 2.733   -21.112 -52.616 1.00 41.64 ? 650 HOH   B O   1 
HETATM 6701 O O   . HOH   I 4 .   ? -24.017 -45.220 -56.775 1.00 50.32 ? 651 HOH   B O   1 
HETATM 6702 O O   . HOH   I 4 .   ? -12.884 -29.003 -62.900 1.00 35.28 ? 652 HOH   B O   1 
HETATM 6703 O O   . HOH   I 4 .   ? -17.359 -12.170 -66.277 1.00 45.22 ? 653 HOH   B O   1 
HETATM 6704 O O   . HOH   I 4 .   ? -22.458 -15.266 -67.681 1.00 46.70 ? 654 HOH   B O   1 
HETATM 6705 O O   . HOH   I 4 .   ? 11.608  -26.912 -63.052 1.00 50.64 ? 655 HOH   B O   1 
HETATM 6706 O O   . HOH   I 4 .   ? -31.865 -21.361 -48.833 1.00 53.30 ? 656 HOH   B O   1 
HETATM 6707 O O   . HOH   I 4 .   ? -14.404 -20.637 -41.759 1.00 43.48 ? 657 HOH   B O   1 
HETATM 6708 O O   . HOH   I 4 .   ? -10.734 -32.855 -76.301 1.00 41.84 ? 658 HOH   B O   1 
HETATM 6709 O O   . HOH   I 4 .   ? -10.704 -26.328 -47.221 1.00 40.31 ? 659 HOH   B O   1 
HETATM 6710 O O   . HOH   I 4 .   ? -14.129 -13.867 -38.264 1.00 43.43 ? 660 HOH   B O   1 
HETATM 6711 O O   . HOH   I 4 .   ? -9.931  -13.481 -44.494 1.00 47.17 ? 661 HOH   B O   1 
HETATM 6712 O O   . HOH   I 4 .   ? -38.205 -16.626 -72.851 1.00 53.31 ? 662 HOH   B O   1 
HETATM 6713 O O   . HOH   I 4 .   ? -8.337  4.500   -50.876 1.00 48.44 ? 663 HOH   B O   1 
HETATM 6714 O O   . HOH   I 4 .   ? -5.179  -15.878 -75.565 1.00 56.29 ? 664 HOH   B O   1 
HETATM 6715 O O   . HOH   I 4 .   ? 0.614   -47.568 -42.746 1.00 50.31 ? 665 HOH   B O   1 
HETATM 6716 O O   . HOH   I 4 .   ? -20.632 -40.163 -52.323 1.00 44.00 ? 666 HOH   B O   1 
HETATM 6717 O O   . HOH   I 4 .   ? -1.161  -20.320 -69.765 1.00 39.31 ? 667 HOH   B O   1 
HETATM 6718 O O   . HOH   I 4 .   ? -26.517 -17.439 -68.450 1.00 47.85 ? 668 HOH   B O   1 
HETATM 6719 O O   . HOH   I 4 .   ? 0.347   -14.901 -39.322 1.00 43.54 ? 669 HOH   B O   1 
HETATM 6720 O O   . HOH   I 4 .   ? -22.164 -36.638 -50.224 1.00 43.89 ? 670 HOH   B O   1 
HETATM 6721 O O   . HOH   I 4 .   ? 12.345  -8.512  -43.792 1.00 50.47 ? 671 HOH   B O   1 
HETATM 6722 O O   . HOH   I 4 .   ? -2.770  -25.680 -47.133 1.00 41.34 ? 672 HOH   B O   1 
HETATM 6723 O O   . HOH   I 4 .   ? 0.785   -9.887  -42.747 1.00 47.31 ? 673 HOH   B O   1 
HETATM 6724 O O   . HOH   I 4 .   ? -29.565 -24.895 -76.172 1.00 50.86 ? 674 HOH   B O   1 
HETATM 6725 O O   . HOH   I 4 .   ? 0.973   -29.364 -38.349 1.00 48.35 ? 675 HOH   B O   1 
HETATM 6726 O O   . HOH   I 4 .   ? -18.422 -41.360 -51.994 1.00 41.43 ? 676 HOH   B O   1 
HETATM 6727 O O   . HOH   I 4 .   ? -0.628  -11.169 -44.514 1.00 43.23 ? 677 HOH   B O   1 
HETATM 6728 O O   . HOH   I 4 .   ? -5.259  -38.446 -65.950 1.00 42.46 ? 678 HOH   B O   1 
HETATM 6729 O O   . HOH   I 4 .   ? -22.246 -18.990 -77.155 1.00 52.40 ? 679 HOH   B O   1 
HETATM 6730 O O   . HOH   I 4 .   ? -2.175  -30.225 -40.929 1.00 48.38 ? 680 HOH   B O   1 
HETATM 6731 O O   . HOH   I 4 .   ? -15.713 -15.947 -44.892 1.00 46.47 ? 681 HOH   B O   1 
HETATM 6732 O O   . HOH   I 4 .   ? 2.962   -17.551 -62.755 1.00 44.53 ? 682 HOH   B O   1 
HETATM 6733 O O   . HOH   I 4 .   ? -19.533 -18.724 -42.899 1.00 46.80 ? 683 HOH   B O   1 
HETATM 6734 O O   . HOH   I 4 .   ? 9.463   -24.191 -51.085 1.00 49.05 ? 684 HOH   B O   1 
HETATM 6735 O O   . HOH   I 4 .   ? -23.874 -35.895 -68.343 1.00 41.29 ? 685 HOH   B O   1 
HETATM 6736 O O   . HOH   I 4 .   ? -7.259  -29.897 -78.945 1.00 44.51 ? 686 HOH   B O   1 
HETATM 6737 O O   . HOH   I 4 .   ? -19.238 -36.305 -71.141 1.00 46.57 ? 687 HOH   B O   1 
HETATM 6738 O O   . HOH   I 4 .   ? 4.224   -35.679 -57.149 1.00 49.49 ? 688 HOH   B O   1 
HETATM 6739 O O   . HOH   I 4 .   ? -29.226 -27.040 -59.068 1.00 42.69 ? 689 HOH   B O   1 
HETATM 6740 O O   . HOH   I 4 .   ? -29.104 -32.940 -69.014 1.00 49.87 ? 690 HOH   B O   1 
HETATM 6741 O O   . HOH   I 4 .   ? -28.313 -28.970 -50.438 1.00 48.58 ? 691 HOH   B O   1 
HETATM 6742 O O   . HOH   I 4 .   ? 0.487   -32.729 -77.440 1.00 45.06 ? 692 HOH   B O   1 
HETATM 6743 O O   . HOH   I 4 .   ? -23.417 -13.803 -69.422 1.00 48.62 ? 693 HOH   B O   1 
HETATM 6744 O O   . HOH   I 4 .   ? -7.130  -5.952  -43.451 1.00 46.57 ? 694 HOH   B O   1 
HETATM 6745 O O   . HOH   I 4 .   ? -10.879 -36.059 -50.191 1.00 45.78 ? 695 HOH   B O   1 
HETATM 6746 O O   . HOH   I 4 .   ? -8.663  -27.577 -45.594 1.00 40.55 ? 696 HOH   B O   1 
HETATM 6747 O O   . HOH   I 4 .   ? 6.712   -26.299 -71.912 1.00 53.10 ? 697 HOH   B O   1 
HETATM 6748 O O   . HOH   I 4 .   ? 9.376   -16.544 -71.775 1.00 56.47 ? 698 HOH   B O   1 
HETATM 6749 O O   . HOH   I 4 .   ? -2.235  -29.111 -43.571 1.00 42.01 ? 699 HOH   B O   1 
HETATM 6750 O O   . HOH   I 4 .   ? -20.400 -17.215 -67.970 1.00 42.28 ? 700 HOH   B O   1 
HETATM 6751 O O   . HOH   I 4 .   ? -23.597 -25.514 -43.028 1.00 51.81 ? 701 HOH   B O   1 
HETATM 6752 O O   . HOH   I 4 .   ? -7.093  1.905   -39.628 1.00 55.84 ? 702 HOH   B O   1 
HETATM 6753 O O   . HOH   I 4 .   ? -37.236 -13.696 -62.238 1.00 52.10 ? 703 HOH   B O   1 
HETATM 6754 O O   . HOH   I 4 .   ? 4.741   -28.467 -73.584 1.00 46.29 ? 704 HOH   B O   1 
HETATM 6755 O O   . HOH   I 4 .   ? -10.042 -46.913 -56.255 1.00 54.66 ? 705 HOH   B O   1 
HETATM 6756 O O   . HOH   I 4 .   ? -12.935 -7.523  -51.555 1.00 44.35 ? 706 HOH   B O   1 
HETATM 6757 O O   . HOH   I 4 .   ? -21.638 -34.516 -71.214 1.00 44.53 ? 707 HOH   B O   1 
HETATM 6758 O O   . HOH   I 4 .   ? -10.029 -47.141 -62.818 1.00 48.94 ? 708 HOH   B O   1 
HETATM 6759 O O   . HOH   I 4 .   ? 7.750   -39.163 -29.929 1.00 46.74 ? 709 HOH   B O   1 
HETATM 6760 O O   . HOH   I 4 .   ? -26.195 -9.155  -57.078 1.00 46.09 ? 710 HOH   B O   1 
HETATM 6761 O O   . HOH   I 4 .   ? 8.521   -33.771 -32.822 1.00 51.42 ? 711 HOH   B O   1 
HETATM 6762 O O   . HOH   I 4 .   ? -14.600 -7.646  -58.739 1.00 47.15 ? 712 HOH   B O   1 
HETATM 6763 O O   . HOH   I 4 .   ? 2.345   -36.700 -58.456 1.00 51.22 ? 713 HOH   B O   1 
HETATM 6764 O O   . HOH   I 4 .   ? -17.581 -39.407 -53.334 1.00 44.90 ? 714 HOH   B O   1 
HETATM 6765 O O   . HOH   I 4 .   ? -9.399  -45.303 -64.286 1.00 38.32 ? 715 HOH   B O   1 
HETATM 6766 O O   . HOH   I 4 .   ? -14.268 -37.044 -43.943 1.00 48.27 ? 716 HOH   B O   1 
HETATM 6767 O O   . HOH   I 4 .   ? 1.630   -36.561 -75.716 1.00 56.70 ? 717 HOH   B O   1 
HETATM 6768 O O   . HOH   I 4 .   ? -21.200 -10.056 -72.069 1.00 55.54 ? 718 HOH   B O   1 
HETATM 6769 O O   . HOH   I 4 .   ? -3.774  -36.142 -74.782 1.00 45.85 ? 719 HOH   B O   1 
HETATM 6770 O O   . HOH   I 4 .   ? -14.984 -8.593  -40.257 1.00 51.00 ? 720 HOH   B O   1 
HETATM 6771 O O   . HOH   I 4 .   ? -16.867 -9.770  -49.095 1.00 48.41 ? 721 HOH   B O   1 
HETATM 6772 O O   . HOH   I 4 .   ? -39.779 -25.060 -70.288 1.00 58.52 ? 722 HOH   B O   1 
HETATM 6773 O O   . HOH   I 4 .   ? 6.154   -34.454 -71.836 1.00 55.28 ? 723 HOH   B O   1 
HETATM 6774 O O   . HOH   I 4 .   ? 18.067  -9.550  -52.613 1.00 50.70 ? 724 HOH   B O   1 
HETATM 6775 O O   . HOH   I 4 .   ? 3.579   -37.432 -74.815 1.00 52.94 ? 725 HOH   B O   1 
HETATM 6776 O O   . HOH   I 4 .   ? 7.017   -33.082 -43.255 1.00 53.85 ? 726 HOH   B O   1 
HETATM 6777 O O   . HOH   I 4 .   ? -31.134 -29.180 -55.599 1.00 46.84 ? 727 HOH   B O   1 
HETATM 6778 O O   . HOH   I 4 .   ? -11.006 -26.573 -38.509 1.00 48.69 ? 728 HOH   B O   1 
HETATM 6779 O O   . HOH   I 4 .   ? 2.907   -28.475 -32.729 1.00 48.19 ? 729 HOH   B O   1 
HETATM 6780 O O   . HOH   I 4 .   ? -5.005  -32.883 -80.087 1.00 48.29 ? 730 HOH   B O   1 
HETATM 6781 O O   . HOH   I 4 .   ? 11.636  -2.455  -57.352 1.00 66.83 ? 731 HOH   B O   1 
HETATM 6782 O O   . HOH   I 4 .   ? -10.637 -44.428 -48.056 1.00 51.97 ? 732 HOH   B O   1 
HETATM 6783 O O   . HOH   I 4 .   ? -12.081 -0.728  -49.042 1.00 50.42 ? 733 HOH   B O   1 
HETATM 6784 O O   . HOH   I 4 .   ? -6.835  -23.117 -80.629 1.00 49.08 ? 734 HOH   B O   1 
HETATM 6785 O O   . HOH   I 4 .   ? 11.084  -18.540 -74.734 1.00 59.87 ? 735 HOH   B O   1 
HETATM 6786 O O   . HOH   I 4 .   ? 14.765  -15.697 -54.603 1.00 54.05 ? 736 HOH   B O   1 
HETATM 6787 O O   . HOH   I 4 .   ? 15.169  -15.169 -69.183 0.50 56.42 ? 737 HOH   B O   1 
HETATM 6788 O O   . HOH   I 4 .   ? -19.175 -41.968 -69.160 1.00 51.95 ? 738 HOH   B O   1 
HETATM 6789 O O   . HOH   I 4 .   ? 9.013   -43.847 -40.165 1.00 45.43 ? 739 HOH   B O   1 
HETATM 6790 O O   . HOH   I 4 .   ? -15.226 -7.293  -50.497 1.00 47.80 ? 740 HOH   B O   1 
HETATM 6791 O O   . HOH   I 4 .   ? 5.351   -24.269 -71.647 1.00 51.58 ? 741 HOH   B O   1 
HETATM 6792 O O   . HOH   I 4 .   ? -18.879 -45.524 -44.911 1.00 52.81 ? 742 HOH   B O   1 
HETATM 6793 O O   . HOH   I 4 .   ? -7.306  -11.621 -40.276 1.00 54.90 ? 743 HOH   B O   1 
HETATM 6794 O O   . HOH   I 4 .   ? -22.234 -51.990 -61.662 1.00 57.81 ? 744 HOH   B O   1 
HETATM 6795 O O   . HOH   I 4 .   ? 12.909  -6.970  -59.122 1.00 51.27 ? 745 HOH   B O   1 
HETATM 6796 O O   . HOH   I 4 .   ? -9.300  -39.831 -72.842 1.00 39.66 ? 746 HOH   B O   1 
HETATM 6797 O O   . HOH   I 4 .   ? -4.062  3.032   -61.982 1.00 66.38 ? 747 HOH   B O   1 
HETATM 6798 O O   . HOH   I 4 .   ? -19.730 -39.725 -69.649 1.00 54.88 ? 748 HOH   B O   1 
HETATM 6799 O O   . HOH   I 4 .   ? -11.931 -16.251 -74.602 1.00 59.56 ? 749 HOH   B O   1 
HETATM 6800 O O   . HOH   I 4 .   ? 8.194   -44.975 -33.743 1.00 52.08 ? 750 HOH   B O   1 
HETATM 6801 O O   . HOH   I 4 .   ? 3.680   -42.289 -52.509 1.00 49.30 ? 751 HOH   B O   1 
HETATM 6802 O O   . HOH   I 4 .   ? -8.462  -42.043 -71.523 1.00 38.71 ? 752 HOH   B O   1 
HETATM 6803 O O   . HOH   I 4 .   ? -35.393 -18.920 -73.038 1.00 56.89 ? 753 HOH   B O   1 
HETATM 6804 O O   . HOH   I 4 .   ? -4.216  -12.222 -35.878 1.00 47.45 ? 754 HOH   B O   1 
HETATM 6805 O O   . HOH   I 4 .   ? 4.761   -31.552 -72.388 1.00 53.90 ? 755 HOH   B O   1 
HETATM 6806 O O   . HOH   I 4 .   ? -26.873 -28.298 -79.443 1.00 51.74 ? 756 HOH   B O   1 
HETATM 6807 O O   . HOH   I 4 .   ? -18.610 -46.050 -47.142 1.00 52.44 ? 757 HOH   B O   1 
HETATM 6808 O O   . HOH   I 4 .   ? -28.707 -10.176 -56.355 1.00 50.10 ? 758 HOH   B O   1 
HETATM 6809 O O   . HOH   I 4 .   ? -19.597 -33.559 -72.667 1.00 48.01 ? 759 HOH   B O   1 
HETATM 6810 O O   . HOH   I 4 .   ? 16.828  -25.211 -60.095 1.00 52.55 ? 760 HOH   B O   1 
HETATM 6811 O O   . HOH   I 4 .   ? -29.037 -4.280  -68.406 1.00 55.25 ? 761 HOH   B O   1 
HETATM 6812 O O   . HOH   I 4 .   ? -7.975  -20.706 -79.716 1.00 54.87 ? 762 HOH   B O   1 
HETATM 6813 O O   . HOH   I 4 .   ? -20.918 -41.529 -48.271 1.00 43.50 ? 763 HOH   B O   1 
HETATM 6814 O O   . HOH   I 4 .   ? -17.016 -11.492 -73.711 1.00 52.64 ? 764 HOH   B O   1 
HETATM 6815 O O   . HOH   I 4 .   ? 8.676   -3.263  -44.550 1.00 55.92 ? 765 HOH   B O   1 
HETATM 6816 O O   . HOH   I 4 .   ? 10.412  -29.165 -74.036 1.00 57.03 ? 766 HOH   B O   1 
HETATM 6817 O O   . HOH   I 4 .   ? 10.822  -24.887 -40.066 1.00 45.61 ? 767 HOH   B O   1 
HETATM 6818 O O   . HOH   I 4 .   ? 1.976   -25.829 -32.548 1.00 47.67 ? 768 HOH   B O   1 
HETATM 6819 O O   . HOH   I 4 .   ? -18.842 -26.159 -42.597 1.00 46.43 ? 769 HOH   B O   1 
HETATM 6820 O O   . HOH   I 4 .   ? -23.727 -16.549 -45.918 1.00 46.78 ? 770 HOH   B O   1 
HETATM 6821 O O   . HOH   I 4 .   ? -4.603  -44.713 -51.857 1.00 54.80 ? 771 HOH   B O   1 
HETATM 6822 O O   . HOH   I 4 .   ? 10.124  -52.375 -36.981 1.00 61.01 ? 772 HOH   B O   1 
HETATM 6823 O O   . HOH   I 4 .   ? -15.195 -11.198 -67.679 1.00 49.69 ? 773 HOH   B O   1 
HETATM 6824 O O   . HOH   I 4 .   ? -14.467 -16.322 -74.808 1.00 54.70 ? 774 HOH   B O   1 
HETATM 6825 O O   . HOH   I 4 .   ? -21.572 -19.261 -41.849 1.00 47.39 ? 775 HOH   B O   1 
HETATM 6826 O O   . HOH   I 4 .   ? -5.158  -9.173  -67.899 1.00 52.70 ? 776 HOH   B O   1 
HETATM 6827 O O   . HOH   I 4 .   ? -8.543  -38.553 -48.948 1.00 48.11 ? 777 HOH   B O   1 
HETATM 6828 O O   . HOH   I 4 .   ? -14.038 -6.083  -56.284 1.00 50.86 ? 778 HOH   B O   1 
HETATM 6829 O O   . HOH   I 4 .   ? -13.515 -7.354  -54.019 1.00 46.00 ? 779 HOH   B O   1 
HETATM 6830 O O   . HOH   I 4 .   ? -18.854 -31.926 -77.233 1.00 60.60 ? 780 HOH   B O   1 
HETATM 6831 O O   . HOH   I 4 .   ? -17.498 -33.509 -78.220 1.00 51.58 ? 781 HOH   B O   1 
HETATM 6832 O O   . HOH   I 4 .   ? -29.496 -29.676 -59.164 1.00 46.28 ? 782 HOH   B O   1 
HETATM 6833 O O   . HOH   I 4 .   ? 14.181  -26.499 -62.481 1.00 49.83 ? 783 HOH   B O   1 
HETATM 6834 O O   . HOH   I 4 .   ? -12.745 -2.187  -53.102 1.00 56.93 ? 784 HOH   B O   1 
HETATM 6835 O O   . HOH   I 4 .   ? -40.752 -15.288 -73.284 1.00 54.96 ? 785 HOH   B O   1 
HETATM 6836 O O   . HOH   I 4 .   ? -9.316  -43.737 -49.882 1.00 44.86 ? 786 HOH   B O   1 
HETATM 6837 O O   . HOH   I 4 .   ? 7.725   -17.425 -74.350 1.00 55.12 ? 787 HOH   B O   1 
HETATM 6838 O O   . HOH   I 4 .   ? -25.333 -38.943 -46.467 1.00 61.94 ? 788 HOH   B O   1 
HETATM 6839 O O   . HOH   I 4 .   ? 9.279   -40.234 -45.363 1.00 63.49 ? 789 HOH   B O   1 
HETATM 6840 O O   . HOH   I 4 .   ? -7.493  -46.520 -57.616 1.00 60.41 ? 790 HOH   B O   1 
HETATM 6841 O O   . HOH   I 4 .   ? -10.993 -19.259 -80.074 1.00 60.17 ? 791 HOH   B O   1 
HETATM 6842 O O   . HOH   I 4 .   ? -15.801 -9.760  -65.777 1.00 44.57 ? 792 HOH   B O   1 
HETATM 6843 O O   . HOH   I 4 .   ? -27.991 -9.441  -53.579 1.00 52.82 ? 793 HOH   B O   1 
HETATM 6844 O O   . HOH   I 4 .   ? -1.155  -34.736 -78.811 1.00 52.74 ? 794 HOH   B O   1 
HETATM 6845 O O   . HOH   I 4 .   ? -22.666 -40.357 -47.288 1.00 55.83 ? 795 HOH   B O   1 
HETATM 6846 O O   . HOH   I 4 .   ? 19.644  -28.105 -48.442 1.00 55.83 ? 796 HOH   B O   1 
HETATM 6847 O O   . HOH   I 4 .   ? -6.995  -10.666 -67.676 1.00 62.97 ? 797 HOH   B O   1 
HETATM 6848 O O   . HOH   I 4 .   ? -7.011  -43.952 -51.290 1.00 51.64 ? 798 HOH   B O   1 
HETATM 6849 O O   . HOH   I 4 .   ? 6.849   -35.750 -56.708 1.00 52.06 ? 799 HOH   B O   1 
HETATM 6850 O O   . HOH   I 4 .   ? -12.993 -17.520 -78.898 1.00 55.07 ? 800 HOH   B O   1 
HETATM 6851 O O   . HOH   I 4 .   ? 0.309   -35.325 -80.967 1.00 60.41 ? 801 HOH   B O   1 
HETATM 6852 O O   . HOH   I 4 .   ? 2.294   -33.893 -82.072 1.00 59.07 ? 802 HOH   B O   1 
HETATM 6853 O O   . HOH   I 4 .   ? -0.455  -36.058 -83.255 1.00 53.41 ? 803 HOH   B O   1 
# 
