data_8XS2
# 
_entry.id   8XS2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XS2         pdb_00008xs2 10.2210/pdb8xs2/pdb 
WWPDB D_1300044014 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-15 
2 'Structure model' 1 1 2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.country'                 
2 2 'Structure model' '_citation.journal_abbrev'          
3 2 'Structure model' '_citation.journal_id_CSD'          
4 2 'Structure model' '_citation.journal_id_ISSN'         
5 2 'Structure model' '_citation.journal_volume'          
6 2 'Structure model' '_citation.pdbx_database_id_DOI'    
7 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8 2 'Structure model' '_citation.title'                   
9 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XS2 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'The same antibody Fab fragment without addition of fluorophore'              5X5X unspecified 
PDB 'The same antibody Fab complexed with osteocalcin C-terminal peptide antigen' 8XS1 unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rarai@shinshu-u.ac.jp 
_pdbx_contact_author.name_first         Ryoichi 
_pdbx_contact_author.name_last          Arai 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5606-8483 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yazaki, S.' 1 ?                   
'Ueda, H.'   2 0000-0001-8849-4217 
'Arai, R.'   3 0000-0001-5606-8483 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? CH ? ? primary 'Int J Mol Sci'   ? ? 1422-0067 ? ? 26 ? ?    ? 
'Crystal Structures of Antigen-Binding Fragment of Anti-Osteocalcin Antibody KTM219.'                                          
2025 ? 10.3390/ijms26020648         39859361 ? ? 
? ? ? ? ? ? ? UK ? ? 1       'Sci Rep'         ? ? 2045-2322 ? ? 4  ? 4640 ? 
'Ultra Q-bodies: quench-based antibody probes that utilize dye-dye interactions with enhanced antigen-dependent fluorescence.' 
2014 ? 10.1038/srep04640            24721819 ? ? 
? ? ? ? ? ? ? CH ? ? 2       'Sensors (Basel)' ? ? 1424-8220 ? ? 21 ? ?    ? 
'Recent Advances in Quenchbody, a Fluorescent Immunosensor.'                                                                   
2021 ? 10.1016/j.cplett.2018.03.011 33572319 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yazaki, S.'  1  ?                   
primary 'Komatsu, M.' 2  ?                   
primary 'Dong, J.'    3  ?                   
primary 'Ueda, H.'    4  0000-0001-8849-4217 
primary 'Arai, R.'    5  0000-0001-5606-8483 
1       'Abe, R.'     6  ?                   
1       'Jeong, H.J.' 7  ?                   
1       'Arakawa, D.' 8  ?                   
1       'Dong, J.'    9  ?                   
1       'Ohashi, H.'  10 ?                   
1       'Kaigome, R.' 11 ?                   
1       'Saiki, F.'   12 ?                   
1       'Yamane, K.'  13 ?                   
1       'Takagi, H.'  14 ?                   
1       'Ueda, H.'    15 0000-0001-8849-4217 
2       'Dong, J.'    16 ?                   
2       'Ueda, H.'    17 0000-0001-8849-4217 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Heavy chain fragment (Fd) of anti-osteocalcin antibody KTM219' 26202.979 1   ? ? ? ? 
2 polymer     man 'Light chain of anti-osteocalcin antibody KTM219'               25259.844 1   ? ? ? ? 
3 non-polymer syn 'ACETATE ION'                                                   59.044    2   ? ? ? ? 
4 water       nat water                                                           18.015    257 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MATGQVKLQQSGAEFVKAGASVKLSCKTSGYTFNNYWIHWVKQSPGQGLEWIGEIDPSDGYSNYNQKFKGKATLTVDKSS
STAYMHLNSLTSEDSAVYYCTSSTSVGGSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSASAAHHHHHHGAAEQKLI
SEEDLNGAA
;
;MATGQVKLQQSGAEFVKAGASVKLSCKTSGYTFNNYWIHWVKQSPGQGLEWIGEIDPSDGYSNYNQKFKGKATLTVDKSS
STAYMHLNSLTSEDSAVYYCTSSTSVGGSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSASAAHHHHHHGAAEQKLI
SEEDLNGAA
;
H ? 
2 'polypeptide(L)' no no 
;MSDIELTQSPLSLPVSLGDQASISCTSSQSLLHSNGDTYLHWYLQKPGQSPKLLIYTLSNRFSGVPDRFSGSGSGTDFTL
KISRVEAADLGIYFCSQTTHVPYTFGGGTKLEIKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA
LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEGGGSDYKDDDDK
;
;MSDIELTQSPLSLPVSLGDQASISCTSSQSLLHSNGDTYLHWYLQKPGQSPKLLIYTLSNRFSGVPDRFSGSGSGTDFTL
KISRVEAADLGIYFCSQTTHVPYTFGGGTKLEIKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA
LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEGGGSDYKDDDDK
;
L ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'ACETATE ION' ACT 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   GLY n 
1 5   GLN n 
1 6   VAL n 
1 7   LYS n 
1 8   LEU n 
1 9   GLN n 
1 10  GLN n 
1 11  SER n 
1 12  GLY n 
1 13  ALA n 
1 14  GLU n 
1 15  PHE n 
1 16  VAL n 
1 17  LYS n 
1 18  ALA n 
1 19  GLY n 
1 20  ALA n 
1 21  SER n 
1 22  VAL n 
1 23  LYS n 
1 24  LEU n 
1 25  SER n 
1 26  CYS n 
1 27  LYS n 
1 28  THR n 
1 29  SER n 
1 30  GLY n 
1 31  TYR n 
1 32  THR n 
1 33  PHE n 
1 34  ASN n 
1 35  ASN n 
1 36  TYR n 
1 37  TRP n 
1 38  ILE n 
1 39  HIS n 
1 40  TRP n 
1 41  VAL n 
1 42  LYS n 
1 43  GLN n 
1 44  SER n 
1 45  PRO n 
1 46  GLY n 
1 47  GLN n 
1 48  GLY n 
1 49  LEU n 
1 50  GLU n 
1 51  TRP n 
1 52  ILE n 
1 53  GLY n 
1 54  GLU n 
1 55  ILE n 
1 56  ASP n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  GLY n 
1 61  TYR n 
1 62  SER n 
1 63  ASN n 
1 64  TYR n 
1 65  ASN n 
1 66  GLN n 
1 67  LYS n 
1 68  PHE n 
1 69  LYS n 
1 70  GLY n 
1 71  LYS n 
1 72  ALA n 
1 73  THR n 
1 74  LEU n 
1 75  THR n 
1 76  VAL n 
1 77  ASP n 
1 78  LYS n 
1 79  SER n 
1 80  SER n 
1 81  SER n 
1 82  THR n 
1 83  ALA n 
1 84  TYR n 
1 85  MET n 
1 86  HIS n 
1 87  LEU n 
1 88  ASN n 
1 89  SER n 
1 90  LEU n 
1 91  THR n 
1 92  SER n 
1 93  GLU n 
1 94  ASP n 
1 95  SER n 
1 96  ALA n 
1 97  VAL n 
1 98  TYR n 
1 99  TYR n 
1 100 CYS n 
1 101 THR n 
1 102 SER n 
1 103 SER n 
1 104 THR n 
1 105 SER n 
1 106 VAL n 
1 107 GLY n 
1 108 GLY n 
1 109 SER n 
1 110 TRP n 
1 111 GLY n 
1 112 GLN n 
1 113 GLY n 
1 114 THR n 
1 115 THR n 
1 116 VAL n 
1 117 THR n 
1 118 VAL n 
1 119 SER n 
1 120 SER n 
1 121 ALA n 
1 122 SER n 
1 123 THR n 
1 124 LYS n 
1 125 GLY n 
1 126 PRO n 
1 127 SER n 
1 128 VAL n 
1 129 PHE n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 PRO n 
1 134 SER n 
1 135 SER n 
1 136 LYS n 
1 137 SER n 
1 138 THR n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 ALA n 
1 144 ALA n 
1 145 LEU n 
1 146 GLY n 
1 147 CYS n 
1 148 LEU n 
1 149 VAL n 
1 150 LYS n 
1 151 ASP n 
1 152 TYR n 
1 153 PHE n 
1 154 PRO n 
1 155 GLU n 
1 156 PRO n 
1 157 VAL n 
1 158 THR n 
1 159 VAL n 
1 160 SER n 
1 161 TRP n 
1 162 ASN n 
1 163 SER n 
1 164 GLY n 
1 165 ALA n 
1 166 LEU n 
1 167 THR n 
1 168 SER n 
1 169 GLY n 
1 170 VAL n 
1 171 HIS n 
1 172 THR n 
1 173 PHE n 
1 174 PRO n 
1 175 ALA n 
1 176 VAL n 
1 177 LEU n 
1 178 GLN n 
1 179 SER n 
1 180 SER n 
1 181 GLY n 
1 182 LEU n 
1 183 TYR n 
1 184 SER n 
1 185 LEU n 
1 186 SER n 
1 187 SER n 
1 188 VAL n 
1 189 VAL n 
1 190 THR n 
1 191 VAL n 
1 192 PRO n 
1 193 SER n 
1 194 SER n 
1 195 SER n 
1 196 LEU n 
1 197 GLY n 
1 198 THR n 
1 199 GLN n 
1 200 THR n 
1 201 TYR n 
1 202 ILE n 
1 203 CYS n 
1 204 ASN n 
1 205 VAL n 
1 206 ASN n 
1 207 HIS n 
1 208 LYS n 
1 209 PRO n 
1 210 SER n 
1 211 ASN n 
1 212 THR n 
1 213 LYS n 
1 214 VAL n 
1 215 ASP n 
1 216 LYS n 
1 217 LYS n 
1 218 VAL n 
1 219 GLU n 
1 220 PRO n 
1 221 LYS n 
1 222 SER n 
1 223 ALA n 
1 224 SER n 
1 225 ALA n 
1 226 ALA n 
1 227 HIS n 
1 228 HIS n 
1 229 HIS n 
1 230 HIS n 
1 231 HIS n 
1 232 HIS n 
1 233 GLY n 
1 234 ALA n 
1 235 ALA n 
1 236 GLU n 
1 237 GLN n 
1 238 LYS n 
1 239 LEU n 
1 240 ILE n 
1 241 SER n 
1 242 GLU n 
1 243 GLU n 
1 244 ASP n 
1 245 LEU n 
1 246 ASN n 
1 247 GLY n 
1 248 ALA n 
1 249 ALA n 
2 1   MET n 
2 2   SER n 
2 3   ASP n 
2 4   ILE n 
2 5   GLU n 
2 6   LEU n 
2 7   THR n 
2 8   GLN n 
2 9   SER n 
2 10  PRO n 
2 11  LEU n 
2 12  SER n 
2 13  LEU n 
2 14  PRO n 
2 15  VAL n 
2 16  SER n 
2 17  LEU n 
2 18  GLY n 
2 19  ASP n 
2 20  GLN n 
2 21  ALA n 
2 22  SER n 
2 23  ILE n 
2 24  SER n 
2 25  CYS n 
2 26  THR n 
2 27  SER n 
2 28  SER n 
2 29  GLN n 
2 30  SER n 
2 31  LEU n 
2 32  LEU n 
2 33  HIS n 
2 34  SER n 
2 35  ASN n 
2 36  GLY n 
2 37  ASP n 
2 38  THR n 
2 39  TYR n 
2 40  LEU n 
2 41  HIS n 
2 42  TRP n 
2 43  TYR n 
2 44  LEU n 
2 45  GLN n 
2 46  LYS n 
2 47  PRO n 
2 48  GLY n 
2 49  GLN n 
2 50  SER n 
2 51  PRO n 
2 52  LYS n 
2 53  LEU n 
2 54  LEU n 
2 55  ILE n 
2 56  TYR n 
2 57  THR n 
2 58  LEU n 
2 59  SER n 
2 60  ASN n 
2 61  ARG n 
2 62  PHE n 
2 63  SER n 
2 64  GLY n 
2 65  VAL n 
2 66  PRO n 
2 67  ASP n 
2 68  ARG n 
2 69  PHE n 
2 70  SER n 
2 71  GLY n 
2 72  SER n 
2 73  GLY n 
2 74  SER n 
2 75  GLY n 
2 76  THR n 
2 77  ASP n 
2 78  PHE n 
2 79  THR n 
2 80  LEU n 
2 81  LYS n 
2 82  ILE n 
2 83  SER n 
2 84  ARG n 
2 85  VAL n 
2 86  GLU n 
2 87  ALA n 
2 88  ALA n 
2 89  ASP n 
2 90  LEU n 
2 91  GLY n 
2 92  ILE n 
2 93  TYR n 
2 94  PHE n 
2 95  CYS n 
2 96  SER n 
2 97  GLN n 
2 98  THR n 
2 99  THR n 
2 100 HIS n 
2 101 VAL n 
2 102 PRO n 
2 103 TYR n 
2 104 THR n 
2 105 PHE n 
2 106 GLY n 
2 107 GLY n 
2 108 GLY n 
2 109 THR n 
2 110 LYS n 
2 111 LEU n 
2 112 GLU n 
2 113 ILE n 
2 114 LYS n 
2 115 ARG n 
2 116 ALA n 
2 117 ASP n 
2 118 ALA n 
2 119 ALA n 
2 120 PRO n 
2 121 SER n 
2 122 VAL n 
2 123 PHE n 
2 124 ILE n 
2 125 PHE n 
2 126 PRO n 
2 127 PRO n 
2 128 SER n 
2 129 ASP n 
2 130 GLU n 
2 131 GLN n 
2 132 LEU n 
2 133 LYS n 
2 134 SER n 
2 135 GLY n 
2 136 THR n 
2 137 ALA n 
2 138 SER n 
2 139 VAL n 
2 140 VAL n 
2 141 CYS n 
2 142 LEU n 
2 143 LEU n 
2 144 ASN n 
2 145 ASN n 
2 146 PHE n 
2 147 TYR n 
2 148 PRO n 
2 149 ARG n 
2 150 GLU n 
2 151 ALA n 
2 152 LYS n 
2 153 VAL n 
2 154 GLN n 
2 155 TRP n 
2 156 LYS n 
2 157 VAL n 
2 158 ASP n 
2 159 ASN n 
2 160 ALA n 
2 161 LEU n 
2 162 GLN n 
2 163 SER n 
2 164 GLY n 
2 165 ASN n 
2 166 SER n 
2 167 GLN n 
2 168 GLU n 
2 169 SER n 
2 170 VAL n 
2 171 THR n 
2 172 GLU n 
2 173 GLN n 
2 174 ASP n 
2 175 SER n 
2 176 LYS n 
2 177 ASP n 
2 178 SER n 
2 179 THR n 
2 180 TYR n 
2 181 SER n 
2 182 LEU n 
2 183 SER n 
2 184 SER n 
2 185 THR n 
2 186 LEU n 
2 187 THR n 
2 188 LEU n 
2 189 SER n 
2 190 LYS n 
2 191 ALA n 
2 192 ASP n 
2 193 TYR n 
2 194 GLU n 
2 195 LYS n 
2 196 HIS n 
2 197 LYS n 
2 198 VAL n 
2 199 TYR n 
2 200 ALA n 
2 201 CYS n 
2 202 GLU n 
2 203 VAL n 
2 204 THR n 
2 205 HIS n 
2 206 GLN n 
2 207 GLY n 
2 208 LEU n 
2 209 SER n 
2 210 SER n 
2 211 PRO n 
2 212 VAL n 
2 213 THR n 
2 214 LYS n 
2 215 SER n 
2 216 PHE n 
2 217 ASN n 
2 218 ARG n 
2 219 GLY n 
2 220 GLU n 
2 221 GLY n 
2 222 GLY n 
2 223 GLY n 
2 224 SER n 
2 225 ASP n 
2 226 TYR n 
2 227 LYS n 
2 228 ASP n 
2 229 ASP n 
2 230 ASP n 
2 231 ASP n 
2 232 LYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 249 ? ? ? ? ? ? ? ? ? 'Mus musculus' 10090 ? 'HYBRIDOMA KTM-219' ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? 'SHuffle T7 Express lysY' ? ? ? ? ? ? ? PLASMID ? ? ? 'pET-Fab(KTM219)' ? ? 
2 1 sample 'Biological sequence' 1 232 ? ? ? ? ? ? ? ? ? 'Mus musculus' 10090 ? 'HYBRIDOMA KTM-219' ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? 'SHuffle T7 Express lysY' ? ? ? ? ? ? ? PLASMID ? ? ? 'pET-Fab(KTM219)' ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'   ? 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   H . n 
A 1 2   ALA 2   -2  ?   ?   ?   H . n 
A 1 3   THR 3   -1  ?   ?   ?   H . n 
A 1 4   GLY 4   0   ?   ?   ?   H . n 
A 1 5   GLN 5   1   1   GLN GLN H . n 
A 1 6   VAL 6   2   2   VAL VAL H . n 
A 1 7   LYS 7   3   3   LYS LYS H . n 
A 1 8   LEU 8   4   4   LEU LEU H . n 
A 1 9   GLN 9   5   5   GLN GLN H . n 
A 1 10  GLN 10  6   6   GLN GLN H . n 
A 1 11  SER 11  7   7   SER SER H . n 
A 1 12  GLY 12  8   8   GLY GLY H . n 
A 1 13  ALA 13  9   9   ALA ALA H . n 
A 1 14  GLU 14  10  10  GLU GLU H . n 
A 1 15  PHE 15  11  11  PHE PHE H . n 
A 1 16  VAL 16  12  12  VAL VAL H . n 
A 1 17  LYS 17  13  13  LYS LYS H . n 
A 1 18  ALA 18  14  14  ALA ALA H . n 
A 1 19  GLY 19  15  15  GLY GLY H . n 
A 1 20  ALA 20  16  16  ALA ALA H . n 
A 1 21  SER 21  17  17  SER SER H . n 
A 1 22  VAL 22  18  18  VAL VAL H . n 
A 1 23  LYS 23  19  19  LYS LYS H . n 
A 1 24  LEU 24  20  20  LEU LEU H . n 
A 1 25  SER 25  21  21  SER SER H . n 
A 1 26  CYS 26  22  22  CYS CYS H . n 
A 1 27  LYS 27  23  23  LYS LYS H . n 
A 1 28  THR 28  24  24  THR THR H . n 
A 1 29  SER 29  25  25  SER SER H . n 
A 1 30  GLY 30  26  26  GLY GLY H . n 
A 1 31  TYR 31  27  27  TYR TYR H . n 
A 1 32  THR 32  28  28  THR THR H . n 
A 1 33  PHE 33  29  29  PHE PHE H . n 
A 1 34  ASN 34  30  30  ASN ASN H . n 
A 1 35  ASN 35  31  31  ASN ASN H . n 
A 1 36  TYR 36  32  32  TYR TYR H . n 
A 1 37  TRP 37  33  33  TRP TRP H . n 
A 1 38  ILE 38  34  34  ILE ILE H . n 
A 1 39  HIS 39  35  35  HIS HIS H . n 
A 1 40  TRP 40  36  36  TRP TRP H . n 
A 1 41  VAL 41  37  37  VAL VAL H . n 
A 1 42  LYS 42  38  38  LYS LYS H . n 
A 1 43  GLN 43  39  39  GLN GLN H . n 
A 1 44  SER 44  40  40  SER SER H . n 
A 1 45  PRO 45  41  41  PRO PRO H . n 
A 1 46  GLY 46  42  42  GLY GLY H . n 
A 1 47  GLN 47  43  43  GLN GLN H . n 
A 1 48  GLY 48  44  44  GLY GLY H . n 
A 1 49  LEU 49  45  45  LEU LEU H . n 
A 1 50  GLU 50  46  46  GLU GLU H . n 
A 1 51  TRP 51  47  47  TRP TRP H . n 
A 1 52  ILE 52  48  48  ILE ILE H . n 
A 1 53  GLY 53  49  49  GLY GLY H . n 
A 1 54  GLU 54  50  50  GLU GLU H . n 
A 1 55  ILE 55  51  51  ILE ILE H . n 
A 1 56  ASP 56  52  52  ASP ASP H . n 
A 1 57  PRO 57  52  52  PRO PRO H A n 
A 1 58  SER 58  53  53  SER SER H . n 
A 1 59  ASP 59  54  54  ASP ASP H . n 
A 1 60  GLY 60  55  55  GLY GLY H . n 
A 1 61  TYR 61  56  56  TYR TYR H . n 
A 1 62  SER 62  57  57  SER SER H . n 
A 1 63  ASN 63  58  58  ASN ASN H . n 
A 1 64  TYR 64  59  59  TYR TYR H . n 
A 1 65  ASN 65  60  60  ASN ASN H . n 
A 1 66  GLN 66  61  61  GLN GLN H . n 
A 1 67  LYS 67  62  62  LYS LYS H . n 
A 1 68  PHE 68  63  63  PHE PHE H . n 
A 1 69  LYS 69  64  64  LYS LYS H . n 
A 1 70  GLY 70  65  65  GLY GLY H . n 
A 1 71  LYS 71  66  66  LYS LYS H . n 
A 1 72  ALA 72  67  67  ALA ALA H . n 
A 1 73  THR 73  68  68  THR THR H . n 
A 1 74  LEU 74  69  69  LEU LEU H . n 
A 1 75  THR 75  70  70  THR THR H . n 
A 1 76  VAL 76  71  71  VAL VAL H . n 
A 1 77  ASP 77  72  72  ASP ASP H . n 
A 1 78  LYS 78  73  73  LYS LYS H . n 
A 1 79  SER 79  74  74  SER SER H . n 
A 1 80  SER 80  75  75  SER SER H . n 
A 1 81  SER 81  76  76  SER SER H . n 
A 1 82  THR 82  77  77  THR THR H . n 
A 1 83  ALA 83  78  78  ALA ALA H . n 
A 1 84  TYR 84  79  79  TYR TYR H . n 
A 1 85  MET 85  80  80  MET MET H . n 
A 1 86  HIS 86  81  81  HIS HIS H . n 
A 1 87  LEU 87  82  82  LEU LEU H . n 
A 1 88  ASN 88  82  82  ASN ASN H A n 
A 1 89  SER 89  82  82  SER SER H B n 
A 1 90  LEU 90  82  82  LEU LEU H C n 
A 1 91  THR 91  83  83  THR THR H . n 
A 1 92  SER 92  84  84  SER SER H . n 
A 1 93  GLU 93  85  85  GLU GLU H . n 
A 1 94  ASP 94  86  86  ASP ASP H . n 
A 1 95  SER 95  87  87  SER SER H . n 
A 1 96  ALA 96  88  88  ALA ALA H . n 
A 1 97  VAL 97  89  89  VAL VAL H . n 
A 1 98  TYR 98  90  90  TYR TYR H . n 
A 1 99  TYR 99  91  91  TYR TYR H . n 
A 1 100 CYS 100 92  92  CYS CYS H . n 
A 1 101 THR 101 93  93  THR THR H . n 
A 1 102 SER 102 94  94  SER SER H . n 
A 1 103 SER 103 95  95  SER SER H . n 
A 1 104 THR 104 96  96  THR THR H . n 
A 1 105 SER 105 97  97  SER SER H . n 
A 1 106 VAL 106 98  98  VAL VAL H . n 
A 1 107 GLY 107 99  99  GLY GLY H . n 
A 1 108 GLY 108 101 101 GLY GLY H . n 
A 1 109 SER 109 102 102 SER SER H . n 
A 1 110 TRP 110 103 103 TRP TRP H . n 
A 1 111 GLY 111 104 104 GLY GLY H . n 
A 1 112 GLN 112 105 105 GLN GLN H . n 
A 1 113 GLY 113 106 106 GLY GLY H . n 
A 1 114 THR 114 107 107 THR THR H . n 
A 1 115 THR 115 108 108 THR THR H . n 
A 1 116 VAL 116 109 109 VAL VAL H . n 
A 1 117 THR 117 110 110 THR THR H . n 
A 1 118 VAL 118 111 111 VAL VAL H . n 
A 1 119 SER 119 112 112 SER SER H . n 
A 1 120 SER 120 113 113 SER SER H . n 
A 1 121 ALA 121 114 114 ALA ALA H . n 
A 1 122 SER 122 115 115 SER SER H . n 
A 1 123 THR 123 116 116 THR THR H . n 
A 1 124 LYS 124 117 117 LYS LYS H . n 
A 1 125 GLY 125 118 118 GLY GLY H . n 
A 1 126 PRO 126 119 119 PRO PRO H . n 
A 1 127 SER 127 120 120 SER SER H . n 
A 1 128 VAL 128 121 121 VAL VAL H . n 
A 1 129 PHE 129 122 122 PHE PHE H . n 
A 1 130 PRO 130 123 123 PRO PRO H . n 
A 1 131 LEU 131 124 124 LEU LEU H . n 
A 1 132 ALA 132 125 125 ALA ALA H . n 
A 1 133 PRO 133 126 126 PRO PRO H . n 
A 1 134 SER 134 127 127 SER SER H . n 
A 1 135 SER 135 128 ?   ?   ?   H . n 
A 1 136 LYS 136 129 ?   ?   ?   H . n 
A 1 137 SER 137 130 ?   ?   ?   H . n 
A 1 138 THR 138 131 ?   ?   ?   H . n 
A 1 139 SER 139 132 ?   ?   ?   H . n 
A 1 140 GLY 140 133 133 GLY GLY H . n 
A 1 141 GLY 141 134 134 GLY GLY H . n 
A 1 142 THR 142 135 135 THR THR H . n 
A 1 143 ALA 143 136 136 ALA ALA H . n 
A 1 144 ALA 144 137 137 ALA ALA H . n 
A 1 145 LEU 145 138 138 LEU LEU H . n 
A 1 146 GLY 146 139 139 GLY GLY H . n 
A 1 147 CYS 147 140 140 CYS CYS H . n 
A 1 148 LEU 148 141 141 LEU LEU H . n 
A 1 149 VAL 149 142 142 VAL VAL H . n 
A 1 150 LYS 150 143 143 LYS LYS H . n 
A 1 151 ASP 151 144 144 ASP ASP H . n 
A 1 152 TYR 152 145 145 TYR TYR H . n 
A 1 153 PHE 153 146 146 PHE PHE H . n 
A 1 154 PRO 154 147 147 PRO PRO H . n 
A 1 155 GLU 155 148 148 GLU GLU H . n 
A 1 156 PRO 156 149 149 PRO PRO H . n 
A 1 157 VAL 157 150 150 VAL VAL H . n 
A 1 158 THR 158 151 151 THR THR H . n 
A 1 159 VAL 159 152 152 VAL VAL H . n 
A 1 160 SER 160 153 153 SER SER H . n 
A 1 161 TRP 161 154 154 TRP TRP H . n 
A 1 162 ASN 162 155 155 ASN ASN H . n 
A 1 163 SER 163 156 156 SER SER H . n 
A 1 164 GLY 164 157 157 GLY GLY H . n 
A 1 165 ALA 165 158 158 ALA ALA H . n 
A 1 166 LEU 166 159 159 LEU LEU H . n 
A 1 167 THR 167 160 160 THR THR H . n 
A 1 168 SER 168 161 161 SER SER H . n 
A 1 169 GLY 169 162 162 GLY GLY H . n 
A 1 170 VAL 170 163 163 VAL VAL H . n 
A 1 171 HIS 171 164 164 HIS HIS H . n 
A 1 172 THR 172 165 165 THR THR H . n 
A 1 173 PHE 173 166 166 PHE PHE H . n 
A 1 174 PRO 174 167 167 PRO PRO H . n 
A 1 175 ALA 175 168 168 ALA ALA H . n 
A 1 176 VAL 176 169 169 VAL VAL H . n 
A 1 177 LEU 177 170 170 LEU LEU H . n 
A 1 178 GLN 178 171 171 GLN GLN H . n 
A 1 179 SER 179 172 172 SER SER H . n 
A 1 180 SER 180 173 173 SER SER H . n 
A 1 181 GLY 181 174 174 GLY GLY H . n 
A 1 182 LEU 182 175 175 LEU LEU H . n 
A 1 183 TYR 183 176 176 TYR TYR H . n 
A 1 184 SER 184 177 177 SER SER H . n 
A 1 185 LEU 185 178 178 LEU LEU H . n 
A 1 186 SER 186 179 179 SER SER H . n 
A 1 187 SER 187 180 180 SER SER H . n 
A 1 188 VAL 188 181 181 VAL VAL H . n 
A 1 189 VAL 189 182 182 VAL VAL H . n 
A 1 190 THR 190 183 183 THR THR H . n 
A 1 191 VAL 191 184 184 VAL VAL H . n 
A 1 192 PRO 192 185 185 PRO PRO H . n 
A 1 193 SER 193 186 186 SER SER H . n 
A 1 194 SER 194 187 187 SER SER H . n 
A 1 195 SER 195 188 188 SER SER H . n 
A 1 196 LEU 196 189 189 LEU LEU H . n 
A 1 197 GLY 197 190 190 GLY GLY H . n 
A 1 198 THR 198 191 191 THR THR H . n 
A 1 199 GLN 199 192 192 GLN GLN H . n 
A 1 200 THR 200 193 193 THR THR H . n 
A 1 201 TYR 201 194 194 TYR TYR H . n 
A 1 202 ILE 202 195 195 ILE ILE H . n 
A 1 203 CYS 203 196 196 CYS CYS H . n 
A 1 204 ASN 204 197 197 ASN ASN H . n 
A 1 205 VAL 205 198 198 VAL VAL H . n 
A 1 206 ASN 206 199 199 ASN ASN H . n 
A 1 207 HIS 207 200 200 HIS HIS H . n 
A 1 208 LYS 208 201 201 LYS LYS H . n 
A 1 209 PRO 209 202 202 PRO PRO H . n 
A 1 210 SER 210 203 203 SER SER H . n 
A 1 211 ASN 211 204 204 ASN ASN H . n 
A 1 212 THR 212 205 205 THR THR H . n 
A 1 213 LYS 213 206 206 LYS LYS H . n 
A 1 214 VAL 214 207 207 VAL VAL H . n 
A 1 215 ASP 215 208 208 ASP ASP H . n 
A 1 216 LYS 216 209 209 LYS LYS H . n 
A 1 217 LYS 217 210 210 LYS LYS H . n 
A 1 218 VAL 218 211 211 VAL VAL H . n 
A 1 219 GLU 219 212 212 GLU GLU H . n 
A 1 220 PRO 220 213 213 PRO PRO H . n 
A 1 221 LYS 221 214 ?   ?   ?   H . n 
A 1 222 SER 222 215 ?   ?   ?   H . n 
A 1 223 ALA 223 216 ?   ?   ?   H . n 
A 1 224 SER 224 217 ?   ?   ?   H . n 
A 1 225 ALA 225 218 ?   ?   ?   H . n 
A 1 226 ALA 226 219 ?   ?   ?   H . n 
A 1 227 HIS 227 220 ?   ?   ?   H . n 
A 1 228 HIS 228 221 ?   ?   ?   H . n 
A 1 229 HIS 229 222 ?   ?   ?   H . n 
A 1 230 HIS 230 223 ?   ?   ?   H . n 
A 1 231 HIS 231 224 ?   ?   ?   H . n 
A 1 232 HIS 232 225 ?   ?   ?   H . n 
A 1 233 GLY 233 226 ?   ?   ?   H . n 
A 1 234 ALA 234 227 ?   ?   ?   H . n 
A 1 235 ALA 235 228 ?   ?   ?   H . n 
A 1 236 GLU 236 229 ?   ?   ?   H . n 
A 1 237 GLN 237 230 ?   ?   ?   H . n 
A 1 238 LYS 238 231 ?   ?   ?   H . n 
A 1 239 LEU 239 232 ?   ?   ?   H . n 
A 1 240 ILE 240 233 ?   ?   ?   H . n 
A 1 241 SER 241 234 ?   ?   ?   H . n 
A 1 242 GLU 242 235 ?   ?   ?   H . n 
A 1 243 GLU 243 236 ?   ?   ?   H . n 
A 1 244 ASP 244 237 ?   ?   ?   H . n 
A 1 245 LEU 245 238 ?   ?   ?   H . n 
A 1 246 ASN 246 239 ?   ?   ?   H . n 
A 1 247 GLY 247 240 ?   ?   ?   H . n 
A 1 248 ALA 248 241 ?   ?   ?   H . n 
A 1 249 ALA 249 242 ?   ?   ?   H . n 
B 2 1   MET 1   -1  ?   ?   ?   L . n 
B 2 2   SER 2   0   0   SER SER L . n 
B 2 3   ASP 3   1   1   ASP ASP L . n 
B 2 4   ILE 4   2   2   ILE ILE L . n 
B 2 5   GLU 5   3   3   GLU GLU L . n 
B 2 6   LEU 6   4   4   LEU LEU L . n 
B 2 7   THR 7   5   5   THR THR L . n 
B 2 8   GLN 8   6   6   GLN GLN L . n 
B 2 9   SER 9   7   7   SER SER L . n 
B 2 10  PRO 10  8   8   PRO PRO L . n 
B 2 11  LEU 11  9   9   LEU LEU L . n 
B 2 12  SER 12  10  10  SER SER L . n 
B 2 13  LEU 13  11  11  LEU LEU L . n 
B 2 14  PRO 14  12  12  PRO PRO L . n 
B 2 15  VAL 15  13  13  VAL VAL L . n 
B 2 16  SER 16  14  14  SER SER L . n 
B 2 17  LEU 17  15  15  LEU LEU L . n 
B 2 18  GLY 18  16  16  GLY GLY L . n 
B 2 19  ASP 19  17  17  ASP ASP L . n 
B 2 20  GLN 20  18  18  GLN GLN L . n 
B 2 21  ALA 21  19  19  ALA ALA L . n 
B 2 22  SER 22  20  20  SER SER L . n 
B 2 23  ILE 23  21  21  ILE ILE L . n 
B 2 24  SER 24  22  22  SER SER L . n 
B 2 25  CYS 25  23  23  CYS CYS L . n 
B 2 26  THR 26  24  24  THR THR L . n 
B 2 27  SER 27  25  25  SER SER L . n 
B 2 28  SER 28  26  26  SER SER L . n 
B 2 29  GLN 29  27  27  GLN GLN L . n 
B 2 30  SER 30  27  27  SER SER L A n 
B 2 31  LEU 31  27  27  LEU LEU L B n 
B 2 32  LEU 32  27  27  LEU LEU L C n 
B 2 33  HIS 33  27  27  HIS HIS L D n 
B 2 34  SER 34  27  27  SER SER L E n 
B 2 35  ASN 35  28  28  ASN ASN L . n 
B 2 36  GLY 36  29  29  GLY GLY L . n 
B 2 37  ASP 37  30  30  ASP ASP L . n 
B 2 38  THR 38  31  31  THR THR L . n 
B 2 39  TYR 39  32  32  TYR TYR L . n 
B 2 40  LEU 40  33  33  LEU LEU L . n 
B 2 41  HIS 41  34  34  HIS HIS L . n 
B 2 42  TRP 42  35  35  TRP TRP L . n 
B 2 43  TYR 43  36  36  TYR TYR L . n 
B 2 44  LEU 44  37  37  LEU LEU L . n 
B 2 45  GLN 45  38  38  GLN GLN L . n 
B 2 46  LYS 46  39  39  LYS LYS L . n 
B 2 47  PRO 47  40  40  PRO PRO L . n 
B 2 48  GLY 48  41  41  GLY GLY L . n 
B 2 49  GLN 49  42  42  GLN GLN L . n 
B 2 50  SER 50  43  43  SER SER L . n 
B 2 51  PRO 51  44  44  PRO PRO L . n 
B 2 52  LYS 52  45  45  LYS LYS L . n 
B 2 53  LEU 53  46  46  LEU LEU L . n 
B 2 54  LEU 54  47  47  LEU LEU L . n 
B 2 55  ILE 55  48  48  ILE ILE L . n 
B 2 56  TYR 56  49  49  TYR TYR L . n 
B 2 57  THR 57  50  50  THR THR L . n 
B 2 58  LEU 58  51  51  LEU LEU L . n 
B 2 59  SER 59  52  52  SER SER L . n 
B 2 60  ASN 60  53  53  ASN ASN L . n 
B 2 61  ARG 61  54  54  ARG ARG L . n 
B 2 62  PHE 62  55  55  PHE PHE L . n 
B 2 63  SER 63  56  56  SER SER L . n 
B 2 64  GLY 64  57  57  GLY GLY L . n 
B 2 65  VAL 65  58  58  VAL VAL L . n 
B 2 66  PRO 66  59  59  PRO PRO L . n 
B 2 67  ASP 67  60  60  ASP ASP L . n 
B 2 68  ARG 68  61  61  ARG ARG L . n 
B 2 69  PHE 69  62  62  PHE PHE L . n 
B 2 70  SER 70  63  63  SER SER L . n 
B 2 71  GLY 71  64  64  GLY GLY L . n 
B 2 72  SER 72  65  65  SER SER L . n 
B 2 73  GLY 73  66  66  GLY GLY L . n 
B 2 74  SER 74  67  67  SER SER L . n 
B 2 75  GLY 75  68  68  GLY GLY L . n 
B 2 76  THR 76  69  69  THR THR L . n 
B 2 77  ASP 77  70  70  ASP ASP L . n 
B 2 78  PHE 78  71  71  PHE PHE L . n 
B 2 79  THR 79  72  72  THR THR L . n 
B 2 80  LEU 80  73  73  LEU LEU L . n 
B 2 81  LYS 81  74  74  LYS LYS L . n 
B 2 82  ILE 82  75  75  ILE ILE L . n 
B 2 83  SER 83  76  76  SER SER L . n 
B 2 84  ARG 84  77  77  ARG ARG L . n 
B 2 85  VAL 85  78  78  VAL VAL L . n 
B 2 86  GLU 86  79  79  GLU GLU L . n 
B 2 87  ALA 87  80  80  ALA ALA L . n 
B 2 88  ALA 88  81  81  ALA ALA L . n 
B 2 89  ASP 89  82  82  ASP ASP L . n 
B 2 90  LEU 90  83  83  LEU LEU L . n 
B 2 91  GLY 91  84  84  GLY GLY L . n 
B 2 92  ILE 92  85  85  ILE ILE L . n 
B 2 93  TYR 93  86  86  TYR TYR L . n 
B 2 94  PHE 94  87  87  PHE PHE L . n 
B 2 95  CYS 95  88  88  CYS CYS L . n 
B 2 96  SER 96  89  89  SER SER L . n 
B 2 97  GLN 97  90  90  GLN GLN L . n 
B 2 98  THR 98  91  91  THR THR L . n 
B 2 99  THR 99  92  92  THR THR L . n 
B 2 100 HIS 100 93  93  HIS HIS L . n 
B 2 101 VAL 101 94  94  VAL VAL L . n 
B 2 102 PRO 102 95  95  PRO PRO L . n 
B 2 103 TYR 103 96  96  TYR TYR L . n 
B 2 104 THR 104 97  97  THR THR L . n 
B 2 105 PHE 105 98  98  PHE PHE L . n 
B 2 106 GLY 106 99  99  GLY GLY L . n 
B 2 107 GLY 107 100 100 GLY GLY L . n 
B 2 108 GLY 108 101 101 GLY GLY L . n 
B 2 109 THR 109 102 102 THR THR L . n 
B 2 110 LYS 110 103 103 LYS LYS L . n 
B 2 111 LEU 111 104 104 LEU LEU L . n 
B 2 112 GLU 112 105 105 GLU GLU L . n 
B 2 113 ILE 113 106 106 ILE ILE L . n 
B 2 114 LYS 114 107 107 LYS LYS L . n 
B 2 115 ARG 115 108 108 ARG ARG L . n 
B 2 116 ALA 116 109 109 ALA ALA L . n 
B 2 117 ASP 117 110 110 ASP ASP L . n 
B 2 118 ALA 118 111 111 ALA ALA L . n 
B 2 119 ALA 119 112 112 ALA ALA L . n 
B 2 120 PRO 120 113 113 PRO PRO L . n 
B 2 121 SER 121 114 114 SER SER L . n 
B 2 122 VAL 122 115 115 VAL VAL L . n 
B 2 123 PHE 123 116 116 PHE PHE L . n 
B 2 124 ILE 124 117 117 ILE ILE L . n 
B 2 125 PHE 125 118 118 PHE PHE L . n 
B 2 126 PRO 126 119 119 PRO PRO L . n 
B 2 127 PRO 127 120 120 PRO PRO L . n 
B 2 128 SER 128 121 121 SER SER L . n 
B 2 129 ASP 129 122 122 ASP ASP L . n 
B 2 130 GLU 130 123 123 GLU GLU L . n 
B 2 131 GLN 131 124 124 GLN GLN L . n 
B 2 132 LEU 132 125 125 LEU LEU L . n 
B 2 133 LYS 133 126 126 LYS LYS L . n 
B 2 134 SER 134 127 127 SER SER L . n 
B 2 135 GLY 135 128 128 GLY GLY L . n 
B 2 136 THR 136 129 129 THR THR L . n 
B 2 137 ALA 137 130 130 ALA ALA L . n 
B 2 138 SER 138 131 131 SER SER L . n 
B 2 139 VAL 139 132 132 VAL VAL L . n 
B 2 140 VAL 140 133 133 VAL VAL L . n 
B 2 141 CYS 141 134 134 CYS CYS L . n 
B 2 142 LEU 142 135 135 LEU LEU L . n 
B 2 143 LEU 143 136 136 LEU LEU L . n 
B 2 144 ASN 144 137 137 ASN ASN L . n 
B 2 145 ASN 145 138 138 ASN ASN L . n 
B 2 146 PHE 146 139 139 PHE PHE L . n 
B 2 147 TYR 147 140 140 TYR TYR L . n 
B 2 148 PRO 148 141 141 PRO PRO L . n 
B 2 149 ARG 149 142 142 ARG ARG L . n 
B 2 150 GLU 150 143 143 GLU GLU L . n 
B 2 151 ALA 151 144 144 ALA ALA L . n 
B 2 152 LYS 152 145 145 LYS LYS L . n 
B 2 153 VAL 153 146 146 VAL VAL L . n 
B 2 154 GLN 154 147 147 GLN GLN L . n 
B 2 155 TRP 155 148 148 TRP TRP L . n 
B 2 156 LYS 156 149 149 LYS LYS L . n 
B 2 157 VAL 157 150 150 VAL VAL L . n 
B 2 158 ASP 158 151 151 ASP ASP L . n 
B 2 159 ASN 159 152 152 ASN ASN L . n 
B 2 160 ALA 160 153 153 ALA ALA L . n 
B 2 161 LEU 161 154 154 LEU LEU L . n 
B 2 162 GLN 162 155 155 GLN GLN L . n 
B 2 163 SER 163 156 156 SER SER L . n 
B 2 164 GLY 164 157 157 GLY GLY L . n 
B 2 165 ASN 165 158 158 ASN ASN L . n 
B 2 166 SER 166 159 159 SER SER L . n 
B 2 167 GLN 167 160 160 GLN GLN L . n 
B 2 168 GLU 168 161 161 GLU GLU L . n 
B 2 169 SER 169 162 162 SER SER L . n 
B 2 170 VAL 170 163 163 VAL VAL L . n 
B 2 171 THR 171 164 164 THR THR L . n 
B 2 172 GLU 172 165 165 GLU GLU L . n 
B 2 173 GLN 173 166 166 GLN GLN L . n 
B 2 174 ASP 174 167 167 ASP ASP L . n 
B 2 175 SER 175 168 168 SER SER L . n 
B 2 176 LYS 176 169 169 LYS LYS L . n 
B 2 177 ASP 177 170 170 ASP ASP L . n 
B 2 178 SER 178 171 171 SER SER L . n 
B 2 179 THR 179 172 172 THR THR L . n 
B 2 180 TYR 180 173 173 TYR TYR L . n 
B 2 181 SER 181 174 174 SER SER L . n 
B 2 182 LEU 182 175 175 LEU LEU L . n 
B 2 183 SER 183 176 176 SER SER L . n 
B 2 184 SER 184 177 177 SER SER L . n 
B 2 185 THR 185 178 178 THR THR L . n 
B 2 186 LEU 186 179 179 LEU LEU L . n 
B 2 187 THR 187 180 180 THR THR L . n 
B 2 188 LEU 188 181 181 LEU LEU L . n 
B 2 189 SER 189 182 182 SER SER L . n 
B 2 190 LYS 190 183 183 LYS LYS L . n 
B 2 191 ALA 191 184 184 ALA ALA L . n 
B 2 192 ASP 192 185 185 ASP ASP L . n 
B 2 193 TYR 193 186 186 TYR TYR L . n 
B 2 194 GLU 194 187 187 GLU GLU L . n 
B 2 195 LYS 195 188 188 LYS LYS L . n 
B 2 196 HIS 196 189 189 HIS HIS L . n 
B 2 197 LYS 197 190 190 LYS LYS L . n 
B 2 198 VAL 198 191 191 VAL VAL L . n 
B 2 199 TYR 199 192 192 TYR TYR L . n 
B 2 200 ALA 200 193 193 ALA ALA L . n 
B 2 201 CYS 201 194 194 CYS CYS L . n 
B 2 202 GLU 202 195 195 GLU GLU L . n 
B 2 203 VAL 203 196 196 VAL VAL L . n 
B 2 204 THR 204 197 197 THR THR L . n 
B 2 205 HIS 205 198 198 HIS HIS L . n 
B 2 206 GLN 206 199 199 GLN GLN L . n 
B 2 207 GLY 207 200 200 GLY GLY L . n 
B 2 208 LEU 208 201 201 LEU LEU L . n 
B 2 209 SER 209 202 202 SER SER L . n 
B 2 210 SER 210 203 203 SER SER L . n 
B 2 211 PRO 211 204 204 PRO PRO L . n 
B 2 212 VAL 212 205 205 VAL VAL L . n 
B 2 213 THR 213 206 206 THR THR L . n 
B 2 214 LYS 214 207 207 LYS LYS L . n 
B 2 215 SER 215 208 208 SER SER L . n 
B 2 216 PHE 216 209 209 PHE PHE L . n 
B 2 217 ASN 217 210 210 ASN ASN L . n 
B 2 218 ARG 218 211 211 ARG ARG L . n 
B 2 219 GLY 219 212 ?   ?   ?   L . n 
B 2 220 GLU 220 213 ?   ?   ?   L . n 
B 2 221 GLY 221 214 ?   ?   ?   L . n 
B 2 222 GLY 222 215 ?   ?   ?   L . n 
B 2 223 GLY 223 216 ?   ?   ?   L . n 
B 2 224 SER 224 217 ?   ?   ?   L . n 
B 2 225 ASP 225 218 ?   ?   ?   L . n 
B 2 226 TYR 226 219 ?   ?   ?   L . n 
B 2 227 LYS 227 220 ?   ?   ?   L . n 
B 2 228 ASP 228 221 ?   ?   ?   L . n 
B 2 229 ASP 229 222 ?   ?   ?   L . n 
B 2 230 ASP 230 223 ?   ?   ?   L . n 
B 2 231 ASP 231 224 ?   ?   ?   L . n 
B 2 232 LYS 232 225 ?   ?   ?   L . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 ACT 1   301 2   ACT ACT H . 
D 3 ACT 1   301 1   ACT ACT L . 
E 4 HOH 1   401 4   HOH HOH H . 
E 4 HOH 2   402 89  HOH HOH H . 
E 4 HOH 3   403 10  HOH HOH H . 
E 4 HOH 4   404 5   HOH HOH H . 
E 4 HOH 5   405 25  HOH HOH H . 
E 4 HOH 6   406 48  HOH HOH H . 
E 4 HOH 7   407 85  HOH HOH H . 
E 4 HOH 8   408 210 HOH HOH H . 
E 4 HOH 9   409 127 HOH HOH H . 
E 4 HOH 10  410 16  HOH HOH H . 
E 4 HOH 11  411 218 HOH HOH H . 
E 4 HOH 12  412 2   HOH HOH H . 
E 4 HOH 13  413 73  HOH HOH H . 
E 4 HOH 14  414 90  HOH HOH H . 
E 4 HOH 15  415 120 HOH HOH H . 
E 4 HOH 16  416 30  HOH HOH H . 
E 4 HOH 17  417 66  HOH HOH H . 
E 4 HOH 18  418 109 HOH HOH H . 
E 4 HOH 19  419 132 HOH HOH H . 
E 4 HOH 20  420 13  HOH HOH H . 
E 4 HOH 21  421 87  HOH HOH H . 
E 4 HOH 22  422 45  HOH HOH H . 
E 4 HOH 23  423 154 HOH HOH H . 
E 4 HOH 24  424 234 HOH HOH H . 
E 4 HOH 25  425 24  HOH HOH H . 
E 4 HOH 26  426 169 HOH HOH H . 
E 4 HOH 27  427 155 HOH HOH H . 
E 4 HOH 28  428 138 HOH HOH H . 
E 4 HOH 29  429 189 HOH HOH H . 
E 4 HOH 30  430 20  HOH HOH H . 
E 4 HOH 31  431 22  HOH HOH H . 
E 4 HOH 32  432 246 HOH HOH H . 
E 4 HOH 33  433 74  HOH HOH H . 
E 4 HOH 34  434 29  HOH HOH H . 
E 4 HOH 35  435 1   HOH HOH H . 
E 4 HOH 36  436 141 HOH HOH H . 
E 4 HOH 37  437 80  HOH HOH H . 
E 4 HOH 38  438 67  HOH HOH H . 
E 4 HOH 39  439 193 HOH HOH H . 
E 4 HOH 40  440 51  HOH HOH H . 
E 4 HOH 41  441 143 HOH HOH H . 
E 4 HOH 42  442 166 HOH HOH H . 
E 4 HOH 43  443 84  HOH HOH H . 
E 4 HOH 44  444 42  HOH HOH H . 
E 4 HOH 45  445 58  HOH HOH H . 
E 4 HOH 46  446 79  HOH HOH H . 
E 4 HOH 47  447 164 HOH HOH H . 
E 4 HOH 48  448 215 HOH HOH H . 
E 4 HOH 49  449 46  HOH HOH H . 
E 4 HOH 50  450 39  HOH HOH H . 
E 4 HOH 51  451 78  HOH HOH H . 
E 4 HOH 52  452 12  HOH HOH H . 
E 4 HOH 53  453 77  HOH HOH H . 
E 4 HOH 54  454 17  HOH HOH H . 
E 4 HOH 55  455 149 HOH HOH H . 
E 4 HOH 56  456 223 HOH HOH H . 
E 4 HOH 57  457 170 HOH HOH H . 
E 4 HOH 58  458 76  HOH HOH H . 
E 4 HOH 59  459 238 HOH HOH H . 
E 4 HOH 60  460 137 HOH HOH H . 
E 4 HOH 61  461 15  HOH HOH H . 
E 4 HOH 62  462 146 HOH HOH H . 
E 4 HOH 63  463 151 HOH HOH H . 
E 4 HOH 64  464 242 HOH HOH H . 
E 4 HOH 65  465 150 HOH HOH H . 
E 4 HOH 66  466 111 HOH HOH H . 
E 4 HOH 67  467 110 HOH HOH H . 
E 4 HOH 68  468 167 HOH HOH H . 
E 4 HOH 69  469 82  HOH HOH H . 
E 4 HOH 70  470 124 HOH HOH H . 
E 4 HOH 71  471 209 HOH HOH H . 
E 4 HOH 72  472 70  HOH HOH H . 
E 4 HOH 73  473 145 HOH HOH H . 
E 4 HOH 74  474 11  HOH HOH H . 
E 4 HOH 75  475 221 HOH HOH H . 
E 4 HOH 76  476 197 HOH HOH H . 
E 4 HOH 77  477 44  HOH HOH H . 
E 4 HOH 78  478 165 HOH HOH H . 
E 4 HOH 79  479 171 HOH HOH H . 
E 4 HOH 80  480 194 HOH HOH H . 
E 4 HOH 81  481 116 HOH HOH H . 
E 4 HOH 82  482 131 HOH HOH H . 
E 4 HOH 83  483 52  HOH HOH H . 
E 4 HOH 84  484 134 HOH HOH H . 
E 4 HOH 85  485 102 HOH HOH H . 
E 4 HOH 86  486 250 HOH HOH H . 
E 4 HOH 87  487 168 HOH HOH H . 
E 4 HOH 88  488 121 HOH HOH H . 
E 4 HOH 89  489 249 HOH HOH H . 
E 4 HOH 90  490 133 HOH HOH H . 
E 4 HOH 91  491 50  HOH HOH H . 
E 4 HOH 92  492 7   HOH HOH H . 
E 4 HOH 93  493 91  HOH HOH H . 
E 4 HOH 94  494 159 HOH HOH H . 
E 4 HOH 95  495 217 HOH HOH H . 
E 4 HOH 96  496 213 HOH HOH H . 
E 4 HOH 97  497 148 HOH HOH H . 
E 4 HOH 98  498 228 HOH HOH H . 
E 4 HOH 99  499 229 HOH HOH H . 
E 4 HOH 100 500 208 HOH HOH H . 
E 4 HOH 101 501 252 HOH HOH H . 
E 4 HOH 102 502 241 HOH HOH H . 
E 4 HOH 103 503 219 HOH HOH H . 
E 4 HOH 104 504 106 HOH HOH H . 
E 4 HOH 105 505 180 HOH HOH H . 
E 4 HOH 106 506 86  HOH HOH H . 
E 4 HOH 107 507 98  HOH HOH H . 
E 4 HOH 108 508 186 HOH HOH H . 
E 4 HOH 109 509 139 HOH HOH H . 
E 4 HOH 110 510 119 HOH HOH H . 
E 4 HOH 111 511 156 HOH HOH H . 
E 4 HOH 112 512 247 HOH HOH H . 
E 4 HOH 113 513 83  HOH HOH H . 
E 4 HOH 114 514 122 HOH HOH H . 
E 4 HOH 115 515 220 HOH HOH H . 
E 4 HOH 116 516 123 HOH HOH H . 
E 4 HOH 117 517 203 HOH HOH H . 
E 4 HOH 118 518 136 HOH HOH H . 
E 4 HOH 119 519 244 HOH HOH H . 
E 4 HOH 120 520 179 HOH HOH H . 
E 4 HOH 121 521 31  HOH HOH H . 
E 4 HOH 122 522 176 HOH HOH H . 
E 4 HOH 123 523 227 HOH HOH H . 
E 4 HOH 124 524 225 HOH HOH H . 
E 4 HOH 125 525 183 HOH HOH H . 
E 4 HOH 126 526 230 HOH HOH H . 
E 4 HOH 127 527 205 HOH HOH H . 
E 4 HOH 128 528 178 HOH HOH H . 
E 4 HOH 129 529 105 HOH HOH H . 
E 4 HOH 130 530 162 HOH HOH H . 
E 4 HOH 131 531 214 HOH HOH H . 
E 4 HOH 132 532 163 HOH HOH H . 
E 4 HOH 133 533 222 HOH HOH H . 
E 4 HOH 134 534 195 HOH HOH H . 
E 4 HOH 135 535 182 HOH HOH H . 
E 4 HOH 136 536 202 HOH HOH H . 
E 4 HOH 137 537 240 HOH HOH H . 
E 4 HOH 138 538 201 HOH HOH H . 
E 4 HOH 139 539 61  HOH HOH H . 
E 4 HOH 140 540 177 HOH HOH H . 
E 4 HOH 141 541 251 HOH HOH H . 
E 4 HOH 142 542 175 HOH HOH H . 
F 4 HOH 1   401 35  HOH HOH L . 
F 4 HOH 2   402 47  HOH HOH L . 
F 4 HOH 3   403 49  HOH HOH L . 
F 4 HOH 4   404 88  HOH HOH L . 
F 4 HOH 5   405 72  HOH HOH L . 
F 4 HOH 6   406 34  HOH HOH L . 
F 4 HOH 7   407 43  HOH HOH L . 
F 4 HOH 8   408 27  HOH HOH L . 
F 4 HOH 9   409 37  HOH HOH L . 
F 4 HOH 10  410 71  HOH HOH L . 
F 4 HOH 11  411 68  HOH HOH L . 
F 4 HOH 12  412 191 HOH HOH L . 
F 4 HOH 13  413 200 HOH HOH L . 
F 4 HOH 14  414 81  HOH HOH L . 
F 4 HOH 15  415 253 HOH HOH L . 
F 4 HOH 16  416 174 HOH HOH L . 
F 4 HOH 17  417 40  HOH HOH L . 
F 4 HOH 18  418 14  HOH HOH L . 
F 4 HOH 19  419 93  HOH HOH L . 
F 4 HOH 20  420 94  HOH HOH L . 
F 4 HOH 21  421 33  HOH HOH L . 
F 4 HOH 22  422 112 HOH HOH L . 
F 4 HOH 23  423 32  HOH HOH L . 
F 4 HOH 24  424 57  HOH HOH L . 
F 4 HOH 25  425 54  HOH HOH L . 
F 4 HOH 26  426 60  HOH HOH L . 
F 4 HOH 27  427 113 HOH HOH L . 
F 4 HOH 28  428 21  HOH HOH L . 
F 4 HOH 29  429 99  HOH HOH L . 
F 4 HOH 30  430 95  HOH HOH L . 
F 4 HOH 31  431 236 HOH HOH L . 
F 4 HOH 32  432 101 HOH HOH L . 
F 4 HOH 33  433 144 HOH HOH L . 
F 4 HOH 34  434 192 HOH HOH L . 
F 4 HOH 35  435 232 HOH HOH L . 
F 4 HOH 36  436 28  HOH HOH L . 
F 4 HOH 37  437 196 HOH HOH L . 
F 4 HOH 38  438 55  HOH HOH L . 
F 4 HOH 39  439 172 HOH HOH L . 
F 4 HOH 40  440 104 HOH HOH L . 
F 4 HOH 41  441 75  HOH HOH L . 
F 4 HOH 42  442 161 HOH HOH L . 
F 4 HOH 43  443 142 HOH HOH L . 
F 4 HOH 44  444 211 HOH HOH L . 
F 4 HOH 45  445 152 HOH HOH L . 
F 4 HOH 46  446 63  HOH HOH L . 
F 4 HOH 47  447 19  HOH HOH L . 
F 4 HOH 48  448 92  HOH HOH L . 
F 4 HOH 49  449 36  HOH HOH L . 
F 4 HOH 50  450 147 HOH HOH L . 
F 4 HOH 51  451 135 HOH HOH L . 
F 4 HOH 52  452 103 HOH HOH L . 
F 4 HOH 53  453 254 HOH HOH L . 
F 4 HOH 54  454 69  HOH HOH L . 
F 4 HOH 55  455 108 HOH HOH L . 
F 4 HOH 56  456 23  HOH HOH L . 
F 4 HOH 57  457 56  HOH HOH L . 
F 4 HOH 58  458 128 HOH HOH L . 
F 4 HOH 59  459 235 HOH HOH L . 
F 4 HOH 60  460 256 HOH HOH L . 
F 4 HOH 61  461 199 HOH HOH L . 
F 4 HOH 62  462 8   HOH HOH L . 
F 4 HOH 63  463 140 HOH HOH L . 
F 4 HOH 64  464 216 HOH HOH L . 
F 4 HOH 65  465 173 HOH HOH L . 
F 4 HOH 66  466 41  HOH HOH L . 
F 4 HOH 67  467 64  HOH HOH L . 
F 4 HOH 68  468 237 HOH HOH L . 
F 4 HOH 69  469 9   HOH HOH L . 
F 4 HOH 70  470 3   HOH HOH L . 
F 4 HOH 71  471 239 HOH HOH L . 
F 4 HOH 72  472 26  HOH HOH L . 
F 4 HOH 73  473 125 HOH HOH L . 
F 4 HOH 74  474 188 HOH HOH L . 
F 4 HOH 75  475 117 HOH HOH L . 
F 4 HOH 76  476 126 HOH HOH L . 
F 4 HOH 77  477 97  HOH HOH L . 
F 4 HOH 78  478 115 HOH HOH L . 
F 4 HOH 79  479 212 HOH HOH L . 
F 4 HOH 80  480 6   HOH HOH L . 
F 4 HOH 81  481 62  HOH HOH L . 
F 4 HOH 82  482 198 HOH HOH L . 
F 4 HOH 83  483 160 HOH HOH L . 
F 4 HOH 84  484 129 HOH HOH L . 
F 4 HOH 85  485 257 HOH HOH L . 
F 4 HOH 86  486 153 HOH HOH L . 
F 4 HOH 87  487 157 HOH HOH L . 
F 4 HOH 88  488 245 HOH HOH L . 
F 4 HOH 89  489 53  HOH HOH L . 
F 4 HOH 90  490 107 HOH HOH L . 
F 4 HOH 91  491 18  HOH HOH L . 
F 4 HOH 92  492 59  HOH HOH L . 
F 4 HOH 93  493 114 HOH HOH L . 
F 4 HOH 94  494 231 HOH HOH L . 
F 4 HOH 95  495 243 HOH HOH L . 
F 4 HOH 96  496 65  HOH HOH L . 
F 4 HOH 97  497 233 HOH HOH L . 
F 4 HOH 98  498 206 HOH HOH L . 
F 4 HOH 99  499 38  HOH HOH L . 
F 4 HOH 100 500 187 HOH HOH L . 
F 4 HOH 101 501 130 HOH HOH L . 
F 4 HOH 102 502 96  HOH HOH L . 
F 4 HOH 103 503 255 HOH HOH L . 
F 4 HOH 104 504 204 HOH HOH L . 
F 4 HOH 105 505 224 HOH HOH L . 
F 4 HOH 106 506 118 HOH HOH L . 
F 4 HOH 107 507 184 HOH HOH L . 
F 4 HOH 108 508 190 HOH HOH L . 
F 4 HOH 109 509 207 HOH HOH L . 
F 4 HOH 110 510 248 HOH HOH L . 
F 4 HOH 111 511 226 HOH HOH L . 
F 4 HOH 112 512 100 HOH HOH L . 
F 4 HOH 113 513 158 HOH HOH L . 
F 4 HOH 114 514 181 HOH HOH L . 
F 4 HOH 115 515 185 HOH HOH L . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0135 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XS2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     66.185 
_cell.length_a_esd                 ? 
_cell.length_b                     69.520 
_cell.length_b_esd                 ? 
_cell.length_c                     96.653 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XS2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XS2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.16 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.07 
_exptl_crystal.description                  'Plate-like crystal' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES, 0.3 M Ammonium Acetate, 25% PEG 3350, 0.6 mM TAMRA' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-02-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Numerical link type Si(111) double crystal' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-5A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-5A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          27.6 
_reflns.entry_id                                       8XS2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.14 
_reflns.d_resolution_low                               50.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24972 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.6 
_reflns.pdbx_netI_over_av_sigmaI                       23.6 
_reflns.pdbx_netI_over_sigmaI                          5.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.993 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.120 
_reflns.pdbx_Rpim_I_all                                0.033 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1.000 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.115 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.14 2.18  ? 2.47 ? ? ? ? 1216 ? ? ? ? ? ? ? ? ? ? ? 11.8 0.918 ? ? 1.060 0.302 ? 1  1 0.815 0.948 ? 98.1  ? 1.015 ? ? ? ? ? ? ? ? 
? 
2.18 2.22  ? 2.80 ? ? ? ? 1220 ? ? ? ? ? ? ? ? ? ? ? 12.2 0.957 ? ? 0.960 0.270 ? 2  1 0.867 0.964 ? 99.9  ? 0.921 ? ? ? ? ? ? ? ? 
? 
2.22 2.26  ? 3.21 ? ? ? ? 1217 ? ? ? ? ? ? ? ? ? ? ? 12.3 0.945 ? ? 0.875 0.246 ? 3  1 0.894 0.972 ? 98.5  ? 0.839 ? ? ? ? ? ? ? ? 
? 
2.26 2.31  ? 3.43 ? ? ? ? 1234 ? ? ? ? ? ? ? ? ? ? ? 12.3 0.949 ? ? 0.815 0.229 ? 4  1 0.908 0.975 ? 99.6  ? 0.782 ? ? ? ? ? ? ? ? 
? 
2.31 2.36  ? 4.31 ? ? ? ? 1212 ? ? ? ? ? ? ? ? ? ? ? 12.2 0.957 ? ? 0.685 0.194 ? 5  1 0.933 0.983 ? 99.1  ? 0.657 ? ? ? ? ? ? ? ? 
? 
2.36 2.41  ? 4.31 ? ? ? ? 1220 ? ? ? ? ? ? ? ? ? ? ? 11.8 0.972 ? ? 0.662 0.190 ? 6  1 0.930 0.982 ? 98.9  ? 0.634 ? ? ? ? ? ? ? ? 
? 
2.41 2.47  ? 5.42 ? ? ? ? 1245 ? ? ? ? ? ? ? ? ? ? ? 12.5 0.983 ? ? 0.564 0.157 ? 7  1 0.963 0.991 ? 99.7  ? 0.541 ? ? ? ? ? ? ? ? 
? 
2.47 2.54  ? 6.67 ? ? ? ? 1225 ? ? ? ? ? ? ? ? ? ? ? 12.2 0.981 ? ? 0.444 0.125 ? 8  1 0.970 0.992 ? 99.4  ? 0.426 ? ? ? ? ? ? ? ? 
? 
2.54 2.61  ? 8.18 ? ? ? ? 1228 ? ? ? ? ? ? ? ? ? ? ? 13.3 0.971 ? ? 0.376 0.102 ? 9  1 0.979 0.995 ? 99.3  ? 0.361 ? ? ? ? ? ? ? ? 
? 
2.61 2.70  ? 9.91 ? ? ? ? 1220 ? ? ? ? ? ? ? ? ? ? ? 13.2 0.996 ? ? 0.320 0.087 ? 10 1 0.985 0.996 ? 99.3  ? 0.307 ? ? ? ? ? ? ? ? 
? 
2.70 2.79  ? 11.2 ? ? ? ? 1244 ? ? ? ? ? ? ? ? ? ? ? 13.1 1.019 ? ? 0.260 0.071 ? 11 1 0.987 0.997 ? 99.5  ? 0.250 ? ? ? ? ? ? ? ? 
? 
2.79 2.90  ? 14.3 ? ? ? ? 1261 ? ? ? ? ? ? ? ? ? ? ? 13.1 1.043 ? ? 0.216 0.059 ? 12 1 0.991 0.998 ? 99.6  ? 0.208 ? ? ? ? ? ? ? ? 
? 
2.90 3.04  ? 16.9 ? ? ? ? 1230 ? ? ? ? ? ? ? ? ? ? ? 12.7 1.068 ? ? 0.175 0.049 ? 13 1 0.994 0.998 ? 99.7  ? 0.168 ? ? ? ? ? ? ? ? 
? 
3.04 3.20  ? 20.7 ? ? ? ? 1246 ? ? ? ? ? ? ? ? ? ? ? 12.5 1.073 ? ? 0.137 0.038 ? 14 1 0.996 0.999 ? 99.8  ? 0.131 ? ? ? ? ? ? ? ? 
? 
3.20 3.40  ? 28.4 ? ? ? ? 1261 ? ? ? ? ? ? ? ? ? ? ? 12.9 1.118 ? ? 0.105 0.029 ? 15 1 0.997 0.999 ? 99.8  ? 0.101 ? ? ? ? ? ? ? ? 
? 
3.40 3.66  ? 40.3 ? ? ? ? 1264 ? ? ? ? ? ? ? ? ? ? ? 13.5 1.130 ? ? 0.078 0.021 ? 16 1 0.999 1.000 ? 99.8  ? 0.075 ? ? ? ? ? ? ? ? 
? 
3.66 4.03  ? 44.8 ? ? ? ? 1267 ? ? ? ? ? ? ? ? ? ? ? 13.3 1.077 ? ? 0.065 0.018 ? 17 1 0.999 1.000 ? 100.0 ? 0.063 ? ? ? ? ? ? ? ? 
? 
4.03 4.61  ? 53.2 ? ? ? ? 1270 ? ? ? ? ? ? ? ? ? ? ? 12.3 1.041 ? ? 0.050 0.014 ? 18 1 0.999 1.000 ? 100.0 ? 0.048 ? ? ? ? ? ? ? ? 
? 
4.61 5.81  ? 57.8 ? ? ? ? 1304 ? ? ? ? ? ? ? ? ? ? ? 12.8 0.913 ? ? 0.043 0.012 ? 19 1 0.999 1.000 ? 99.9  ? 0.041 ? ? ? ? ? ? ? ? 
? 
5.81 50.00 ? 58.9 ? ? ? ? 1388 ? ? ? ? ? ? ? ? ? ? ? 12.0 0.736 ? ? 0.035 0.010 ? 20 1 1.000 1.000 ? 99.9  ? 0.033 ? ? ? ? ? ? ? ? 
? 
# 
_refine.aniso_B[1][1]                            -0.40 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            -0.24 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            0.64 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               30.028 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.945 
_refine.correlation_coeff_Fo_to_Fc_free          0.919 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XS2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.14 
_refine.ls_d_res_low                             50.0 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23209 
_refine.ls_number_reflns_R_free                  1193 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.95 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20438 
_refine.ls_R_factor_R_free                       0.24426 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20245 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5X5X 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.275 
_refine.pdbx_overall_ESU_R_Free                  0.209 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             6.033 
_refine.overall_SU_ML                            0.150 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.14 
_refine_hist.d_res_low                        50.0 
_refine_hist.number_atoms_solvent             257 
_refine_hist.number_atoms_total               3502 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3237 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.019  3327 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  3039 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.456  1.947  4523 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.903  3.000  7054 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.019  5.000  427  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 36.081 25.079 126  ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 14.215 15.000 531  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 21.643 15.000 6    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.076  0.200  513  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.005  0.021  3757 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  731  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 1.640  2.934  1712 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.637  2.930  1709 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 2.711  4.383  2134 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.711  4.385  2135 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 1.729  3.034  1614 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.728  3.035  1615 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.879  4.471  2389 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.151  23.477 3685 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 5.157  23.479 3685 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.143 
_refine_ls_shell.d_res_low                        2.199 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             63 
_refine_ls_shell.number_reflns_R_work             1265 
_refine_ls_shell.percent_reflns_obs               72.37 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.276 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.329 
# 
_struct.entry_id                     8XS2 
_struct.title                        
'Crystal structure of Fab fragment of anti-osteocalcin C-terminal peptide antibody KTM219 with addition of fluorophore TAMRA' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XS2 
_struct_keywords.text            
'Antibody, Immunoglobulin fold, Osteocalcin, Quenchbody (Q-body), Open sandwich immunoassay, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8XS2 8XS2 ? 1 ? 1 
2 PDB 8XS2 8XS2 ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XS2 H 1 ? 249 ? 8XS2 -3 ? 242 ? -3 242 
2 2 8XS2 L 1 ? 232 ? 8XS2 -1 ? 225 ? -1 225 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3190  ? 
1 MORE         -23   ? 
1 'SSA (A^2)'  19650 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 32  ? TYR A 36  ? THR H 28  TYR H 32  5 ? 5 
HELX_P HELX_P2 AA2 THR A 91  ? SER A 95  ? THR H 83  SER H 87  5 ? 5 
HELX_P HELX_P3 AA3 SER A 103 ? GLY A 107 ? SER H 95  GLY H 99  5 ? 5 
HELX_P HELX_P4 AA4 SER A 194 ? LEU A 196 ? SER H 187 LEU H 189 5 ? 3 
HELX_P HELX_P5 AA5 GLU B 86  ? LEU B 90  ? GLU L 79  LEU L 83  5 ? 5 
HELX_P HELX_P6 AA6 SER B 128 ? SER B 134 ? SER L 121 SER L 127 1 ? 7 
HELX_P HELX_P7 AA7 LYS B 190 ? GLU B 194 ? LYS L 183 GLU L 187 1 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 26  SG ? ? ? 1_555 A CYS 100 SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.139 ? ? 
disulf2 disulf ? ? A CYS 147 SG ? ? ? 1_555 A CYS 203 SG ? ? H CYS 140 H CYS 196 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf3 disulf ? ? B CYS 25  SG ? ? ? 1_555 B CYS 95  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.067 ? ? 
disulf4 disulf ? ? B CYS 141 SG ? ? ? 1_555 B CYS 201 SG ? ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.049 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 26  ? CYS A 100 ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 147 ? CYS A 203 ? CYS H 140 ? 1_555 CYS H 196 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 25  ? CYS B 95  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 141 ? CYS B 201 ? CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 153 A . ? PHE 146 H PRO 154 A ? PRO 147 H 1 -8.15 
2 GLU 155 A . ? GLU 148 H PRO 156 A ? PRO 149 H 1 -5.79 
3 SER 9   B . ? SER 7   L PRO 10  B ? PRO 8   L 1 -6.25 
4 VAL 101 B . ? VAL 94  L PRO 102 B ? PRO 95  L 1 2.19  
5 TYR 147 B . ? TYR 140 L PRO 148 B ? PRO 141 L 1 3.06  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
AA7 ? 6 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA7 5 6 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LYS A 7   ? GLN A 10  ? LYS H 3   GLN H 6   
AA1 2 VAL A 22  ? SER A 29  ? VAL H 18  SER H 25  
AA1 3 THR A 82  ? LEU A 87  ? THR H 77  LEU H 82  
AA1 4 ALA A 72  ? ASP A 77  ? ALA H 67  ASP H 72  
AA2 1 GLU A 14  ? VAL A 16  ? GLU H 10  VAL H 12  
AA2 2 THR A 114 ? VAL A 118 ? THR H 107 VAL H 111 
AA2 3 ALA A 96  ? THR A 101 ? ALA H 88  THR H 93  
AA2 4 ILE A 38  ? SER A 44  ? ILE H 34  SER H 40  
AA2 5 GLY A 48  ? ILE A 55  ? GLY H 44  ILE H 51  
AA2 6 SER A 62  ? TYR A 64  ? SER H 57  TYR H 59  
AA3 1 SER A 127 ? LEU A 131 ? SER H 120 LEU H 124 
AA3 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA3 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA3 4 VAL A 170 ? THR A 172 ? VAL H 163 THR H 165 
AA4 1 SER A 127 ? LEU A 131 ? SER H 120 LEU H 124 
AA4 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA4 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA4 4 VAL A 176 ? LEU A 177 ? VAL H 169 LEU H 170 
AA5 1 THR A 158 ? TRP A 161 ? THR H 151 TRP H 154 
AA5 2 TYR A 201 ? HIS A 207 ? TYR H 194 HIS H 200 
AA5 3 THR A 212 ? VAL A 218 ? THR H 205 VAL H 211 
AA6 1 LEU B 6   ? SER B 9   ? LEU L 4   SER L 7   
AA6 2 ALA B 21  ? SER B 27  ? ALA L 19  SER L 25  
AA6 3 ASP B 77  ? ILE B 82  ? ASP L 70  ILE L 75  
AA6 4 PHE B 69  ? SER B 74  ? PHE L 62  SER L 67  
AA7 1 SER B 12  ? VAL B 15  ? SER L 10  VAL L 13  
AA7 2 THR B 109 ? ILE B 113 ? THR L 102 ILE L 106 
AA7 3 GLY B 91  ? GLN B 97  ? GLY L 84  GLN L 90  
AA7 4 LEU B 40  ? GLN B 45  ? LEU L 33  GLN L 38  
AA7 5 LYS B 52  ? TYR B 56  ? LYS L 45  TYR L 49  
AA7 6 ASN B 60  ? ARG B 61  ? ASN L 53  ARG L 54  
AA8 1 SER B 12  ? VAL B 15  ? SER L 10  VAL L 13  
AA8 2 THR B 109 ? ILE B 113 ? THR L 102 ILE L 106 
AA8 3 GLY B 91  ? GLN B 97  ? GLY L 84  GLN L 90  
AA8 4 THR B 104 ? PHE B 105 ? THR L 97  PHE L 98  
AA9 1 SER B 121 ? PHE B 125 ? SER L 114 PHE L 118 
AA9 2 THR B 136 ? PHE B 146 ? THR L 129 PHE L 139 
AA9 3 TYR B 180 ? SER B 189 ? TYR L 173 SER L 182 
AA9 4 SER B 166 ? VAL B 170 ? SER L 159 VAL L 163 
AB1 1 ALA B 160 ? LEU B 161 ? ALA L 153 LEU L 154 
AB1 2 LYS B 152 ? VAL B 157 ? LYS L 145 VAL L 150 
AB1 3 VAL B 198 ? THR B 204 ? VAL L 191 THR L 197 
AB1 4 VAL B 212 ? ASN B 217 ? VAL L 205 ASN L 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 9   ? N GLN H 5   O LYS A 27  ? O LYS H 23  
AA1 2 3 N LEU A 24  ? N LEU H 20  O MET A 85  ? O MET H 80  
AA1 3 4 O TYR A 84  ? O TYR H 79  N THR A 75  ? N THR H 70  
AA2 1 2 N GLU A 14  ? N GLU H 10  O THR A 117 ? O THR H 110 
AA2 2 3 O VAL A 116 ? O VAL H 109 N ALA A 96  ? N ALA H 88  
AA2 3 4 O TYR A 99  ? O TYR H 91  N VAL A 41  ? N VAL H 37  
AA2 4 5 N LYS A 42  ? N LYS H 38  O GLU A 50  ? O GLU H 46  
AA2 5 6 N GLU A 54  ? N GLU H 50  O ASN A 63  ? O ASN H 58  
AA3 1 2 N PHE A 129 ? N PHE H 122 O LEU A 148 ? O LEU H 141 
AA3 2 3 N VAL A 149 ? N VAL H 142 O LEU A 185 ? O LEU H 178 
AA3 3 4 O VAL A 188 ? O VAL H 181 N HIS A 171 ? N HIS H 164 
AA4 1 2 N PHE A 129 ? N PHE H 122 O LEU A 148 ? O LEU H 141 
AA4 2 3 N VAL A 149 ? N VAL H 142 O LEU A 185 ? O LEU H 178 
AA4 3 4 O SER A 184 ? O SER H 177 N VAL A 176 ? N VAL H 169 
AA5 1 2 N SER A 160 ? N SER H 153 O ASN A 204 ? O ASN H 197 
AA5 2 3 N VAL A 205 ? N VAL H 198 O VAL A 214 ? O VAL H 207 
AA6 1 2 N THR B 7   ? N THR L 5   O THR B 26  ? O THR L 24  
AA6 2 3 N ILE B 23  ? N ILE L 21  O LEU B 80  ? O LEU L 73  
AA6 3 4 O LYS B 81  ? O LYS L 74  N SER B 70  ? N SER L 63  
AA7 1 2 N LEU B 13  ? N LEU L 11  O LYS B 110 ? O LYS L 103 
AA7 2 3 O LEU B 111 ? O LEU L 104 N GLY B 91  ? N GLY L 84  
AA7 3 4 O PHE B 94  ? O PHE L 87  N TYR B 43  ? N TYR L 36  
AA7 4 5 N TRP B 42  ? N TRP L 35  O ILE B 55  ? O ILE L 48  
AA7 5 6 N TYR B 56  ? N TYR L 49  O ASN B 60  ? O ASN L 53  
AA8 1 2 N LEU B 13  ? N LEU L 11  O LYS B 110 ? O LYS L 103 
AA8 2 3 O LEU B 111 ? O LEU L 104 N GLY B 91  ? N GLY L 84  
AA8 3 4 N GLN B 97  ? N GLN L 90  O THR B 104 ? O THR L 97  
AA9 1 2 N PHE B 123 ? N PHE L 116 O LEU B 142 ? O LEU L 135 
AA9 2 3 N VAL B 139 ? N VAL L 132 O LEU B 186 ? O LEU L 179 
AA9 3 4 O THR B 185 ? O THR L 178 N GLN B 167 ? N GLN L 160 
AB1 1 2 O ALA B 160 ? O ALA L 153 N VAL B 157 ? N VAL L 150 
AB1 2 3 N GLN B 154 ? N GLN L 147 O GLU B 202 ? O GLU L 195 
AB1 3 4 N VAL B 203 ? N VAL L 196 O VAL B 212 ? O VAL L 205 
# 
_pdbx_entry_details.entry_id                   8XS2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             H 
_pdbx_validate_rmsd_angle.auth_comp_id_1             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_1              22 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             H 
_pdbx_validate_rmsd_angle.auth_comp_id_2             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_2              22 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             SG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             H 
_pdbx_validate_rmsd_angle.auth_comp_id_3             CYS 
_pdbx_validate_rmsd_angle.auth_seq_id_3              22 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                123.23 
_pdbx_validate_rmsd_angle.angle_target_value         114.20 
_pdbx_validate_rmsd_angle.angle_deviation            9.03 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.10 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA H 114 ? ? -37.65  144.13 
2 1 THR H 160 ? ? -132.46 -32.17 
3 1 THR L 50  ? ? 33.74   63.70  
4 1 LEU L 51  ? ? 84.29   -64.04 
5 1 ASN L 138 ? ? 47.87   71.50  
6 1 ASN L 152 ? ? 69.45   -1.10  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 H MET -3  ? A MET 1   
2  1 Y 1 H ALA -2  ? A ALA 2   
3  1 Y 1 H THR -1  ? A THR 3   
4  1 Y 1 H GLY 0   ? A GLY 4   
5  1 Y 1 H SER 128 ? A SER 135 
6  1 Y 1 H LYS 129 ? A LYS 136 
7  1 Y 1 H SER 130 ? A SER 137 
8  1 Y 1 H THR 131 ? A THR 138 
9  1 Y 1 H SER 132 ? A SER 139 
10 1 Y 1 H LYS 214 ? A LYS 221 
11 1 Y 1 H SER 215 ? A SER 222 
12 1 Y 1 H ALA 216 ? A ALA 223 
13 1 Y 1 H SER 217 ? A SER 224 
14 1 Y 1 H ALA 218 ? A ALA 225 
15 1 Y 1 H ALA 219 ? A ALA 226 
16 1 Y 1 H HIS 220 ? A HIS 227 
17 1 Y 1 H HIS 221 ? A HIS 228 
18 1 Y 1 H HIS 222 ? A HIS 229 
19 1 Y 1 H HIS 223 ? A HIS 230 
20 1 Y 1 H HIS 224 ? A HIS 231 
21 1 Y 1 H HIS 225 ? A HIS 232 
22 1 Y 1 H GLY 226 ? A GLY 233 
23 1 Y 1 H ALA 227 ? A ALA 234 
24 1 Y 1 H ALA 228 ? A ALA 235 
25 1 Y 1 H GLU 229 ? A GLU 236 
26 1 Y 1 H GLN 230 ? A GLN 237 
27 1 Y 1 H LYS 231 ? A LYS 238 
28 1 Y 1 H LEU 232 ? A LEU 239 
29 1 Y 1 H ILE 233 ? A ILE 240 
30 1 Y 1 H SER 234 ? A SER 241 
31 1 Y 1 H GLU 235 ? A GLU 242 
32 1 Y 1 H GLU 236 ? A GLU 243 
33 1 Y 1 H ASP 237 ? A ASP 244 
34 1 Y 1 H LEU 238 ? A LEU 245 
35 1 Y 1 H ASN 239 ? A ASN 246 
36 1 Y 1 H GLY 240 ? A GLY 247 
37 1 Y 1 H ALA 241 ? A ALA 248 
38 1 Y 1 H ALA 242 ? A ALA 249 
39 1 Y 1 L MET -1  ? B MET 1   
40 1 Y 1 L GLY 212 ? B GLY 219 
41 1 Y 1 L GLU 213 ? B GLU 220 
42 1 Y 1 L GLY 214 ? B GLY 221 
43 1 Y 1 L GLY 215 ? B GLY 222 
44 1 Y 1 L GLY 216 ? B GLY 223 
45 1 Y 1 L SER 217 ? B SER 224 
46 1 Y 1 L ASP 218 ? B ASP 225 
47 1 Y 1 L TYR 219 ? B TYR 226 
48 1 Y 1 L LYS 220 ? B LYS 227 
49 1 Y 1 L ASP 221 ? B ASP 228 
50 1 Y 1 L ASP 222 ? B ASP 229 
51 1 Y 1 L ASP 223 ? B ASP 230 
52 1 Y 1 L ASP 224 ? B ASP 231 
53 1 Y 1 L LYS 225 ? B LYS 232 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
HIS N    N N N 144 
HIS CA   C N S 145 
HIS C    C N N 146 
HIS O    O N N 147 
HIS CB   C N N 148 
HIS CG   C Y N 149 
HIS ND1  N Y N 150 
HIS CD2  C Y N 151 
HIS CE1  C Y N 152 
HIS NE2  N Y N 153 
HIS OXT  O N N 154 
HIS H    H N N 155 
HIS H2   H N N 156 
HIS HA   H N N 157 
HIS HB2  H N N 158 
HIS HB3  H N N 159 
HIS HD1  H N N 160 
HIS HD2  H N N 161 
HIS HE1  H N N 162 
HIS HE2  H N N 163 
HIS HXT  H N N 164 
HOH O    O N N 165 
HOH H1   H N N 166 
HOH H2   H N N 167 
ILE N    N N N 168 
ILE CA   C N S 169 
ILE C    C N N 170 
ILE O    O N N 171 
ILE CB   C N S 172 
ILE CG1  C N N 173 
ILE CG2  C N N 174 
ILE CD1  C N N 175 
ILE OXT  O N N 176 
ILE H    H N N 177 
ILE H2   H N N 178 
ILE HA   H N N 179 
ILE HB   H N N 180 
ILE HG12 H N N 181 
ILE HG13 H N N 182 
ILE HG21 H N N 183 
ILE HG22 H N N 184 
ILE HG23 H N N 185 
ILE HD11 H N N 186 
ILE HD12 H N N 187 
ILE HD13 H N N 188 
ILE HXT  H N N 189 
LEU N    N N N 190 
LEU CA   C N S 191 
LEU C    C N N 192 
LEU O    O N N 193 
LEU CB   C N N 194 
LEU CG   C N N 195 
LEU CD1  C N N 196 
LEU CD2  C N N 197 
LEU OXT  O N N 198 
LEU H    H N N 199 
LEU H2   H N N 200 
LEU HA   H N N 201 
LEU HB2  H N N 202 
LEU HB3  H N N 203 
LEU HG   H N N 204 
LEU HD11 H N N 205 
LEU HD12 H N N 206 
LEU HD13 H N N 207 
LEU HD21 H N N 208 
LEU HD22 H N N 209 
LEU HD23 H N N 210 
LEU HXT  H N N 211 
LYS N    N N N 212 
LYS CA   C N S 213 
LYS C    C N N 214 
LYS O    O N N 215 
LYS CB   C N N 216 
LYS CG   C N N 217 
LYS CD   C N N 218 
LYS CE   C N N 219 
LYS NZ   N N N 220 
LYS OXT  O N N 221 
LYS H    H N N 222 
LYS H2   H N N 223 
LYS HA   H N N 224 
LYS HB2  H N N 225 
LYS HB3  H N N 226 
LYS HG2  H N N 227 
LYS HG3  H N N 228 
LYS HD2  H N N 229 
LYS HD3  H N N 230 
LYS HE2  H N N 231 
LYS HE3  H N N 232 
LYS HZ1  H N N 233 
LYS HZ2  H N N 234 
LYS HZ3  H N N 235 
LYS HXT  H N N 236 
MET N    N N N 237 
MET CA   C N S 238 
MET C    C N N 239 
MET O    O N N 240 
MET CB   C N N 241 
MET CG   C N N 242 
MET SD   S N N 243 
MET CE   C N N 244 
MET OXT  O N N 245 
MET H    H N N 246 
MET H2   H N N 247 
MET HA   H N N 248 
MET HB2  H N N 249 
MET HB3  H N N 250 
MET HG2  H N N 251 
MET HG3  H N N 252 
MET HE1  H N N 253 
MET HE2  H N N 254 
MET HE3  H N N 255 
MET HXT  H N N 256 
PHE N    N N N 257 
PHE CA   C N S 258 
PHE C    C N N 259 
PHE O    O N N 260 
PHE CB   C N N 261 
PHE CG   C Y N 262 
PHE CD1  C Y N 263 
PHE CD2  C Y N 264 
PHE CE1  C Y N 265 
PHE CE2  C Y N 266 
PHE CZ   C Y N 267 
PHE OXT  O N N 268 
PHE H    H N N 269 
PHE H2   H N N 270 
PHE HA   H N N 271 
PHE HB2  H N N 272 
PHE HB3  H N N 273 
PHE HD1  H N N 274 
PHE HD2  H N N 275 
PHE HE1  H N N 276 
PHE HE2  H N N 277 
PHE HZ   H N N 278 
PHE HXT  H N N 279 
PRO N    N N N 280 
PRO CA   C N S 281 
PRO C    C N N 282 
PRO O    O N N 283 
PRO CB   C N N 284 
PRO CG   C N N 285 
PRO CD   C N N 286 
PRO OXT  O N N 287 
PRO H    H N N 288 
PRO HA   H N N 289 
PRO HB2  H N N 290 
PRO HB3  H N N 291 
PRO HG2  H N N 292 
PRO HG3  H N N 293 
PRO HD2  H N N 294 
PRO HD3  H N N 295 
PRO HXT  H N N 296 
SER N    N N N 297 
SER CA   C N S 298 
SER C    C N N 299 
SER O    O N N 300 
SER CB   C N N 301 
SER OG   O N N 302 
SER OXT  O N N 303 
SER H    H N N 304 
SER H2   H N N 305 
SER HA   H N N 306 
SER HB2  H N N 307 
SER HB3  H N N 308 
SER HG   H N N 309 
SER HXT  H N N 310 
THR N    N N N 311 
THR CA   C N S 312 
THR C    C N N 313 
THR O    O N N 314 
THR CB   C N R 315 
THR OG1  O N N 316 
THR CG2  C N N 317 
THR OXT  O N N 318 
THR H    H N N 319 
THR H2   H N N 320 
THR HA   H N N 321 
THR HB   H N N 322 
THR HG1  H N N 323 
THR HG21 H N N 324 
THR HG22 H N N 325 
THR HG23 H N N 326 
THR HXT  H N N 327 
TRP N    N N N 328 
TRP CA   C N S 329 
TRP C    C N N 330 
TRP O    O N N 331 
TRP CB   C N N 332 
TRP CG   C Y N 333 
TRP CD1  C Y N 334 
TRP CD2  C Y N 335 
TRP NE1  N Y N 336 
TRP CE2  C Y N 337 
TRP CE3  C Y N 338 
TRP CZ2  C Y N 339 
TRP CZ3  C Y N 340 
TRP CH2  C Y N 341 
TRP OXT  O N N 342 
TRP H    H N N 343 
TRP H2   H N N 344 
TRP HA   H N N 345 
TRP HB2  H N N 346 
TRP HB3  H N N 347 
TRP HD1  H N N 348 
TRP HE1  H N N 349 
TRP HE3  H N N 350 
TRP HZ2  H N N 351 
TRP HZ3  H N N 352 
TRP HH2  H N N 353 
TRP HXT  H N N 354 
TYR N    N N N 355 
TYR CA   C N S 356 
TYR C    C N N 357 
TYR O    O N N 358 
TYR CB   C N N 359 
TYR CG   C Y N 360 
TYR CD1  C Y N 361 
TYR CD2  C Y N 362 
TYR CE1  C Y N 363 
TYR CE2  C Y N 364 
TYR CZ   C Y N 365 
TYR OH   O N N 366 
TYR OXT  O N N 367 
TYR H    H N N 368 
TYR H2   H N N 369 
TYR HA   H N N 370 
TYR HB2  H N N 371 
TYR HB3  H N N 372 
TYR HD1  H N N 373 
TYR HD2  H N N 374 
TYR HE1  H N N 375 
TYR HE2  H N N 376 
TYR HH   H N N 377 
TYR HXT  H N N 378 
VAL N    N N N 379 
VAL CA   C N S 380 
VAL C    C N N 381 
VAL O    O N N 382 
VAL CB   C N N 383 
VAL CG1  C N N 384 
VAL CG2  C N N 385 
VAL OXT  O N N 386 
VAL H    H N N 387 
VAL H2   H N N 388 
VAL HA   H N N 389 
VAL HB   H N N 390 
VAL HG11 H N N 391 
VAL HG12 H N N 392 
VAL HG13 H N N 393 
VAL HG21 H N N 394 
VAL HG22 H N N 395 
VAL HG23 H N N 396 
VAL HXT  H N N 397 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
HIS N   CA   sing N N 135 
HIS N   H    sing N N 136 
HIS N   H2   sing N N 137 
HIS CA  C    sing N N 138 
HIS CA  CB   sing N N 139 
HIS CA  HA   sing N N 140 
HIS C   O    doub N N 141 
HIS C   OXT  sing N N 142 
HIS CB  CG   sing N N 143 
HIS CB  HB2  sing N N 144 
HIS CB  HB3  sing N N 145 
HIS CG  ND1  sing Y N 146 
HIS CG  CD2  doub Y N 147 
HIS ND1 CE1  doub Y N 148 
HIS ND1 HD1  sing N N 149 
HIS CD2 NE2  sing Y N 150 
HIS CD2 HD2  sing N N 151 
HIS CE1 NE2  sing Y N 152 
HIS CE1 HE1  sing N N 153 
HIS NE2 HE2  sing N N 154 
HIS OXT HXT  sing N N 155 
HOH O   H1   sing N N 156 
HOH O   H2   sing N N 157 
ILE N   CA   sing N N 158 
ILE N   H    sing N N 159 
ILE N   H2   sing N N 160 
ILE CA  C    sing N N 161 
ILE CA  CB   sing N N 162 
ILE CA  HA   sing N N 163 
ILE C   O    doub N N 164 
ILE C   OXT  sing N N 165 
ILE CB  CG1  sing N N 166 
ILE CB  CG2  sing N N 167 
ILE CB  HB   sing N N 168 
ILE CG1 CD1  sing N N 169 
ILE CG1 HG12 sing N N 170 
ILE CG1 HG13 sing N N 171 
ILE CG2 HG21 sing N N 172 
ILE CG2 HG22 sing N N 173 
ILE CG2 HG23 sing N N 174 
ILE CD1 HD11 sing N N 175 
ILE CD1 HD12 sing N N 176 
ILE CD1 HD13 sing N N 177 
ILE OXT HXT  sing N N 178 
LEU N   CA   sing N N 179 
LEU N   H    sing N N 180 
LEU N   H2   sing N N 181 
LEU CA  C    sing N N 182 
LEU CA  CB   sing N N 183 
LEU CA  HA   sing N N 184 
LEU C   O    doub N N 185 
LEU C   OXT  sing N N 186 
LEU CB  CG   sing N N 187 
LEU CB  HB2  sing N N 188 
LEU CB  HB3  sing N N 189 
LEU CG  CD1  sing N N 190 
LEU CG  CD2  sing N N 191 
LEU CG  HG   sing N N 192 
LEU CD1 HD11 sing N N 193 
LEU CD1 HD12 sing N N 194 
LEU CD1 HD13 sing N N 195 
LEU CD2 HD21 sing N N 196 
LEU CD2 HD22 sing N N 197 
LEU CD2 HD23 sing N N 198 
LEU OXT HXT  sing N N 199 
LYS N   CA   sing N N 200 
LYS N   H    sing N N 201 
LYS N   H2   sing N N 202 
LYS CA  C    sing N N 203 
LYS CA  CB   sing N N 204 
LYS CA  HA   sing N N 205 
LYS C   O    doub N N 206 
LYS C   OXT  sing N N 207 
LYS CB  CG   sing N N 208 
LYS CB  HB2  sing N N 209 
LYS CB  HB3  sing N N 210 
LYS CG  CD   sing N N 211 
LYS CG  HG2  sing N N 212 
LYS CG  HG3  sing N N 213 
LYS CD  CE   sing N N 214 
LYS CD  HD2  sing N N 215 
LYS CD  HD3  sing N N 216 
LYS CE  NZ   sing N N 217 
LYS CE  HE2  sing N N 218 
LYS CE  HE3  sing N N 219 
LYS NZ  HZ1  sing N N 220 
LYS NZ  HZ2  sing N N 221 
LYS NZ  HZ3  sing N N 222 
LYS OXT HXT  sing N N 223 
MET N   CA   sing N N 224 
MET N   H    sing N N 225 
MET N   H2   sing N N 226 
MET CA  C    sing N N 227 
MET CA  CB   sing N N 228 
MET CA  HA   sing N N 229 
MET C   O    doub N N 230 
MET C   OXT  sing N N 231 
MET CB  CG   sing N N 232 
MET CB  HB2  sing N N 233 
MET CB  HB3  sing N N 234 
MET CG  SD   sing N N 235 
MET CG  HG2  sing N N 236 
MET CG  HG3  sing N N 237 
MET SD  CE   sing N N 238 
MET CE  HE1  sing N N 239 
MET CE  HE2  sing N N 240 
MET CE  HE3  sing N N 241 
MET OXT HXT  sing N N 242 
PHE N   CA   sing N N 243 
PHE N   H    sing N N 244 
PHE N   H2   sing N N 245 
PHE CA  C    sing N N 246 
PHE CA  CB   sing N N 247 
PHE CA  HA   sing N N 248 
PHE C   O    doub N N 249 
PHE C   OXT  sing N N 250 
PHE CB  CG   sing N N 251 
PHE CB  HB2  sing N N 252 
PHE CB  HB3  sing N N 253 
PHE CG  CD1  doub Y N 254 
PHE CG  CD2  sing Y N 255 
PHE CD1 CE1  sing Y N 256 
PHE CD1 HD1  sing N N 257 
PHE CD2 CE2  doub Y N 258 
PHE CD2 HD2  sing N N 259 
PHE CE1 CZ   doub Y N 260 
PHE CE1 HE1  sing N N 261 
PHE CE2 CZ   sing Y N 262 
PHE CE2 HE2  sing N N 263 
PHE CZ  HZ   sing N N 264 
PHE OXT HXT  sing N N 265 
PRO N   CA   sing N N 266 
PRO N   CD   sing N N 267 
PRO N   H    sing N N 268 
PRO CA  C    sing N N 269 
PRO CA  CB   sing N N 270 
PRO CA  HA   sing N N 271 
PRO C   O    doub N N 272 
PRO C   OXT  sing N N 273 
PRO CB  CG   sing N N 274 
PRO CB  HB2  sing N N 275 
PRO CB  HB3  sing N N 276 
PRO CG  CD   sing N N 277 
PRO CG  HG2  sing N N 278 
PRO CG  HG3  sing N N 279 
PRO CD  HD2  sing N N 280 
PRO CD  HD3  sing N N 281 
PRO OXT HXT  sing N N 282 
SER N   CA   sing N N 283 
SER N   H    sing N N 284 
SER N   H2   sing N N 285 
SER CA  C    sing N N 286 
SER CA  CB   sing N N 287 
SER CA  HA   sing N N 288 
SER C   O    doub N N 289 
SER C   OXT  sing N N 290 
SER CB  OG   sing N N 291 
SER CB  HB2  sing N N 292 
SER CB  HB3  sing N N 293 
SER OG  HG   sing N N 294 
SER OXT HXT  sing N N 295 
THR N   CA   sing N N 296 
THR N   H    sing N N 297 
THR N   H2   sing N N 298 
THR CA  C    sing N N 299 
THR CA  CB   sing N N 300 
THR CA  HA   sing N N 301 
THR C   O    doub N N 302 
THR C   OXT  sing N N 303 
THR CB  OG1  sing N N 304 
THR CB  CG2  sing N N 305 
THR CB  HB   sing N N 306 
THR OG1 HG1  sing N N 307 
THR CG2 HG21 sing N N 308 
THR CG2 HG22 sing N N 309 
THR CG2 HG23 sing N N 310 
THR OXT HXT  sing N N 311 
TRP N   CA   sing N N 312 
TRP N   H    sing N N 313 
TRP N   H2   sing N N 314 
TRP CA  C    sing N N 315 
TRP CA  CB   sing N N 316 
TRP CA  HA   sing N N 317 
TRP C   O    doub N N 318 
TRP C   OXT  sing N N 319 
TRP CB  CG   sing N N 320 
TRP CB  HB2  sing N N 321 
TRP CB  HB3  sing N N 322 
TRP CG  CD1  doub Y N 323 
TRP CG  CD2  sing Y N 324 
TRP CD1 NE1  sing Y N 325 
TRP CD1 HD1  sing N N 326 
TRP CD2 CE2  doub Y N 327 
TRP CD2 CE3  sing Y N 328 
TRP NE1 CE2  sing Y N 329 
TRP NE1 HE1  sing N N 330 
TRP CE2 CZ2  sing Y N 331 
TRP CE3 CZ3  doub Y N 332 
TRP CE3 HE3  sing N N 333 
TRP CZ2 CH2  doub Y N 334 
TRP CZ2 HZ2  sing N N 335 
TRP CZ3 CH2  sing Y N 336 
TRP CZ3 HZ3  sing N N 337 
TRP CH2 HH2  sing N N 338 
TRP OXT HXT  sing N N 339 
TYR N   CA   sing N N 340 
TYR N   H    sing N N 341 
TYR N   H2   sing N N 342 
TYR CA  C    sing N N 343 
TYR CA  CB   sing N N 344 
TYR CA  HA   sing N N 345 
TYR C   O    doub N N 346 
TYR C   OXT  sing N N 347 
TYR CB  CG   sing N N 348 
TYR CB  HB2  sing N N 349 
TYR CB  HB3  sing N N 350 
TYR CG  CD1  doub Y N 351 
TYR CG  CD2  sing Y N 352 
TYR CD1 CE1  sing Y N 353 
TYR CD1 HD1  sing N N 354 
TYR CD2 CE2  doub Y N 355 
TYR CD2 HD2  sing N N 356 
TYR CE1 CZ   doub Y N 357 
TYR CE1 HE1  sing N N 358 
TYR CE2 CZ   sing Y N 359 
TYR CE2 HE2  sing N N 360 
TYR CZ  OH   sing N N 361 
TYR OH  HH   sing N N 362 
TYR OXT HXT  sing N N 363 
VAL N   CA   sing N N 364 
VAL N   H    sing N N 365 
VAL N   H2   sing N N 366 
VAL CA  C    sing N N 367 
VAL CA  CB   sing N N 368 
VAL CA  HA   sing N N 369 
VAL C   O    doub N N 370 
VAL C   OXT  sing N N 371 
VAL CB  CG1  sing N N 372 
VAL CB  CG2  sing N N 373 
VAL CB  HB   sing N N 374 
VAL CG1 HG11 sing N N 375 
VAL CG1 HG12 sing N N 376 
VAL CG1 HG13 sing N N 377 
VAL CG2 HG21 sing N N 378 
VAL CG2 HG22 sing N N 379 
VAL CG2 HG23 sing N N 380 
VAL OXT HXT  sing N N 381 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)'                      Japan 
'JP19H02522, JP17KK0104, JP16K05841, JP16H00761, JP24780097, JP15H04191, JP18H03851'      1 
'Ministry of Education, Culture, Sports, Science and Technology (Japan)' Japan 
'Cooperative Research Program of Network Joint Research Center for Materials and Devices' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5X5X 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8XS2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015109 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014384 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010346 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 5   ? 85.840  56.601  115.272 1.00 56.05 ? 1   GLN H N   1 
ATOM   2    C CA  . GLN A 1 5   ? 85.173  56.129  114.020 1.00 56.35 ? 1   GLN H CA  1 
ATOM   3    C C   . GLN A 1 5   ? 84.318  57.249  113.411 1.00 50.10 ? 1   GLN H C   1 
ATOM   4    O O   . GLN A 1 5   ? 84.807  57.960  112.545 1.00 49.69 ? 1   GLN H O   1 
ATOM   5    C CB  . GLN A 1 5   ? 84.360  54.838  114.251 1.00 60.30 ? 1   GLN H CB  1 
ATOM   6    C CG  . GLN A 1 5   ? 85.173  53.634  114.736 1.00 66.09 ? 1   GLN H CG  1 
ATOM   7    C CD  . GLN A 1 5   ? 86.097  53.040  113.682 1.00 69.78 ? 1   GLN H CD  1 
ATOM   8    O OE1 . GLN A 1 5   ? 87.321  53.124  113.803 1.00 74.70 ? 1   GLN H OE1 1 
ATOM   9    N NE2 . GLN A 1 5   ? 85.516  52.418  112.655 1.00 70.84 ? 1   GLN H NE2 1 
ATOM   10   N N   . VAL A 1 6   ? 83.088  57.440  113.894 1.00 45.99 ? 2   VAL H N   1 
ATOM   11   C CA  . VAL A 1 6   ? 82.123  58.358  113.249 1.00 44.91 ? 2   VAL H CA  1 
ATOM   12   C C   . VAL A 1 6   ? 82.567  59.824  113.260 1.00 43.20 ? 2   VAL H C   1 
ATOM   13   O O   . VAL A 1 6   ? 82.883  60.376  114.309 1.00 42.76 ? 2   VAL H O   1 
ATOM   14   C CB  . VAL A 1 6   ? 80.719  58.264  113.875 1.00 43.98 ? 2   VAL H CB  1 
ATOM   15   C CG1 . VAL A 1 6   ? 79.778  59.323  113.303 1.00 44.27 ? 2   VAL H CG1 1 
ATOM   16   C CG2 . VAL A 1 6   ? 80.138  56.888  113.617 1.00 44.34 ? 2   VAL H CG2 1 
ATOM   17   N N   . LYS A 1 7   ? 82.560  60.440  112.079 1.00 40.14 ? 3   LYS H N   1 
ATOM   18   C CA  . LYS A 1 7   ? 82.968  61.832  111.907 1.00 38.15 ? 3   LYS H CA  1 
ATOM   19   C C   . LYS A 1 7   ? 82.061  62.549  110.933 1.00 36.62 ? 3   LYS H C   1 
ATOM   20   O O   . LYS A 1 7   ? 81.680  61.986  109.915 1.00 34.07 ? 3   LYS H O   1 
ATOM   21   C CB  . LYS A 1 7   ? 84.402  61.916  111.405 1.00 38.86 ? 3   LYS H CB  1 
ATOM   22   C CG  . LYS A 1 7   ? 85.407  61.530  112.470 1.00 39.91 ? 3   LYS H CG  1 
ATOM   23   C CD  . LYS A 1 7   ? 86.816  61.544  111.930 1.00 39.46 ? 3   LYS H CD  1 
ATOM   24   C CE  . LYS A 1 7   ? 87.743  60.792  112.864 1.00 40.62 ? 3   LYS H CE  1 
ATOM   25   N NZ  . LYS A 1 7   ? 89.109  61.370  112.801 1.00 41.16 ? 3   LYS H NZ  1 
ATOM   26   N N   . LEU A 1 8   ? 81.729  63.792  111.274 1.00 34.07 ? 4   LEU H N   1 
ATOM   27   C CA  . LEU A 1 8   ? 80.932  64.662  110.442 1.00 33.91 ? 4   LEU H CA  1 
ATOM   28   C C   . LEU A 1 8   ? 81.742  65.931  110.228 1.00 33.11 ? 4   LEU H C   1 
ATOM   29   O O   . LEU A 1 8   ? 81.812  66.784  111.107 1.00 34.15 ? 4   LEU H O   1 
ATOM   30   C CB  . LEU A 1 8   ? 79.603  64.953  111.127 1.00 34.58 ? 4   LEU H CB  1 
ATOM   31   C CG  . LEU A 1 8   ? 78.806  63.668  111.395 1.00 36.61 ? 4   LEU H CG  1 
ATOM   32   C CD1 . LEU A 1 8   ? 78.031  63.703  112.701 1.00 38.46 ? 4   LEU H CD1 1 
ATOM   33   C CD2 . LEU A 1 8   ? 77.864  63.400  110.259 1.00 37.06 ? 4   LEU H CD2 1 
ATOM   34   N N   . GLN A 1 9   ? 82.375  66.034  109.065 1.00 29.76 ? 5   GLN H N   1 
ATOM   35   C CA  . GLN A 1 9   ? 83.255  67.151  108.761 1.00 30.06 ? 5   GLN H CA  1 
ATOM   36   C C   . GLN A 1 9   ? 82.549  68.196  107.891 1.00 27.43 ? 5   GLN H C   1 
ATOM   37   O O   . GLN A 1 9   ? 82.416  68.030  106.684 1.00 27.00 ? 5   GLN H O   1 
ATOM   38   C CB  . GLN A 1 9   ? 84.532  66.652  108.059 1.00 31.87 ? 5   GLN H CB  1 
ATOM   39   C CG  . GLN A 1 9   ? 85.564  67.749  107.797 1.00 34.52 ? 5   GLN H CG  1 
ATOM   40   C CD  . GLN A 1 9   ? 86.114  68.357  109.080 1.00 38.11 ? 5   GLN H CD  1 
ATOM   41   O OE1 . GLN A 1 9   ? 86.134  67.702  110.127 1.00 40.58 ? 5   GLN H OE1 1 
ATOM   42   N NE2 . GLN A 1 9   ? 86.580  69.607  109.005 1.00 39.64 ? 5   GLN H NE2 1 
ATOM   43   N N   . GLN A 1 10  ? 82.116  69.278  108.517 1.00 25.36 ? 6   GLN H N   1 
ATOM   44   C CA  . GLN A 1 10  ? 81.413  70.344  107.827 1.00 23.91 ? 6   GLN H CA  1 
ATOM   45   C C   . GLN A 1 10  ? 82.377  71.297  107.107 1.00 25.21 ? 6   GLN H C   1 
ATOM   46   O O   . GLN A 1 10  ? 83.561  71.340  107.401 1.00 22.67 ? 6   GLN H O   1 
ATOM   47   C CB  . GLN A 1 10  ? 80.497  71.104  108.791 1.00 21.86 ? 6   GLN H CB  1 
ATOM   48   C CG  . GLN A 1 10  ? 79.312  70.256  109.267 1.00 21.07 ? 6   GLN H CG  1 
ATOM   49   C CD  . GLN A 1 10  ? 78.320  71.036  110.118 1.00 20.24 ? 6   GLN H CD  1 
ATOM   50   O OE1 . GLN A 1 10  ? 78.159  70.760  111.305 1.00 18.99 ? 6   GLN H OE1 1 
ATOM   51   N NE2 . GLN A 1 10  ? 77.660  72.020  109.519 1.00 20.06 ? 6   GLN H NE2 1 
ATOM   52   N N   . SER A 1 11  ? 81.837  72.049  106.153 1.00 25.77 ? 7   SER H N   1 
ATOM   53   C CA  . SER A 1 11  ? 82.621  73.001  105.360 1.00 25.14 ? 7   SER H CA  1 
ATOM   54   C C   . SER A 1 11  ? 82.864  74.276  106.154 1.00 24.79 ? 7   SER H C   1 
ATOM   55   O O   . SER A 1 11  ? 82.195  74.533  107.148 1.00 25.66 ? 7   SER H O   1 
ATOM   56   C CB  . SER A 1 11  ? 81.892  73.335  104.041 1.00 24.49 ? 7   SER H CB  1 
ATOM   57   O OG  . SER A 1 11  ? 80.498  73.599  104.247 1.00 23.58 ? 7   SER H OG  1 
ATOM   58   N N   . GLY A 1 12  ? 83.805  75.083  105.675 1.00 23.78 ? 8   GLY H N   1 
ATOM   59   C CA  . GLY A 1 12  ? 84.200  76.322  106.331 1.00 23.93 ? 8   GLY H CA  1 
ATOM   60   C C   . GLY A 1 12  ? 83.202  77.466  106.294 1.00 24.61 ? 8   GLY H C   1 
ATOM   61   O O   . GLY A 1 12  ? 82.182  77.415  105.603 1.00 25.39 ? 8   GLY H O   1 
ATOM   62   N N   . ALA A 1 13  ? 83.525  78.512  107.052 1.00 25.18 ? 9   ALA H N   1 
ATOM   63   C CA  . ALA A 1 13  ? 82.713  79.721  107.166 1.00 26.31 ? 9   ALA H CA  1 
ATOM   64   C C   . ALA A 1 13  ? 82.367  80.333  105.814 1.00 27.51 ? 9   ALA H C   1 
ATOM   65   O O   . ALA A 1 13  ? 83.118  80.177  104.863 1.00 26.53 ? 9   ALA H O   1 
ATOM   66   C CB  . ALA A 1 13  ? 83.439  80.737  108.009 1.00 26.25 ? 9   ALA H CB  1 
ATOM   67   N N   . GLU A 1 14  ? 81.225  81.024  105.750 1.00 29.06 ? 10  GLU H N   1 
ATOM   68   C CA  . GLU A 1 14  ? 80.725  81.633  104.517 1.00 29.45 ? 10  GLU H CA  1 
ATOM   69   C C   . GLU A 1 14  ? 80.410  83.080  104.814 1.00 31.24 ? 10  GLU H C   1 
ATOM   70   O O   . GLU A 1 14  ? 79.785  83.387  105.836 1.00 34.09 ? 10  GLU H O   1 
ATOM   71   C CB  . GLU A 1 14  ? 79.455  80.934  104.031 1.00 31.24 ? 10  GLU H CB  1 
ATOM   72   C CG  . GLU A 1 14  ? 79.635  79.470  103.642 1.00 30.49 ? 10  GLU H CG  1 
ATOM   73   C CD  . GLU A 1 14  ? 80.235  79.272  102.258 1.00 30.97 ? 10  GLU H CD  1 
ATOM   74   O OE1 . GLU A 1 14  ? 80.383  80.258  101.498 1.00 30.91 ? 10  GLU H OE1 1 
ATOM   75   O OE2 . GLU A 1 14  ? 80.561  78.113  101.931 1.00 31.61 ? 10  GLU H OE2 1 
ATOM   76   N N   . PHE A 1 15  ? 80.878  83.970  103.943 1.00 30.90 ? 11  PHE H N   1 
ATOM   77   C CA  . PHE A 1 15  ? 80.562  85.378  104.030 1.00 30.39 ? 11  PHE H CA  1 
ATOM   78   C C   . PHE A 1 15  ? 79.952  85.740  102.702 1.00 33.61 ? 11  PHE H C   1 
ATOM   79   O O   . PHE A 1 15  ? 80.631  85.698  101.685 1.00 32.93 ? 11  PHE H O   1 
ATOM   80   C CB  . PHE A 1 15  ? 81.810  86.198  104.288 1.00 28.74 ? 11  PHE H CB  1 
ATOM   81   C CG  . PHE A 1 15  ? 82.447  85.907  105.609 1.00 25.94 ? 11  PHE H CG  1 
ATOM   82   C CD1 . PHE A 1 15  ? 82.042  86.583  106.751 1.00 24.85 ? 11  PHE H CD1 1 
ATOM   83   C CD2 . PHE A 1 15  ? 83.449  84.957  105.714 1.00 25.83 ? 11  PHE H CD2 1 
ATOM   84   C CE1 . PHE A 1 15  ? 82.620  86.314  107.989 1.00 24.15 ? 11  PHE H CE1 1 
ATOM   85   C CE2 . PHE A 1 15  ? 84.048  84.693  106.949 1.00 25.87 ? 11  PHE H CE2 1 
ATOM   86   C CZ  . PHE A 1 15  ? 83.624  85.373  108.086 1.00 24.49 ? 11  PHE H CZ  1 
ATOM   87   N N   . VAL A 1 16  ? 78.653  86.041  102.716 1.00 35.41 ? 12  VAL H N   1 
ATOM   88   C CA  . VAL A 1 16  ? 77.897  86.268  101.495 1.00 37.32 ? 12  VAL H CA  1 
ATOM   89   C C   . VAL A 1 16  ? 76.916  87.387  101.704 1.00 39.39 ? 12  VAL H C   1 
ATOM   90   O O   . VAL A 1 16  ? 76.639  87.787  102.833 1.00 41.95 ? 12  VAL H O   1 
ATOM   91   C CB  . VAL A 1 16  ? 77.152  85.007  101.032 1.00 38.22 ? 12  VAL H CB  1 
ATOM   92   C CG1 . VAL A 1 16  ? 78.141  83.882  100.790 1.00 38.97 ? 12  VAL H CG1 1 
ATOM   93   C CG2 . VAL A 1 16  ? 76.091  84.581  102.032 1.00 38.68 ? 12  VAL H CG2 1 
ATOM   94   N N   . LYS A 1 17  ? 76.387  87.886  100.601 1.00 40.93 ? 13  LYS H N   1 
ATOM   95   C CA  . LYS A 1 17  ? 75.538  89.072  100.625 1.00 41.24 ? 13  LYS H CA  1 
ATOM   96   C C   . LYS A 1 17  ? 74.086  88.668  100.554 1.00 36.82 ? 13  LYS H C   1 
ATOM   97   O O   . LYS A 1 17  ? 73.766  87.550  100.162 1.00 33.23 ? 13  LYS H O   1 
ATOM   98   C CB  . LYS A 1 17  ? 75.927  89.998  99.475  1.00 46.72 ? 13  LYS H CB  1 
ATOM   99   C CG  . LYS A 1 17  ? 77.429  90.298  99.473  1.00 50.49 ? 13  LYS H CG  1 
ATOM   100  C CD  . LYS A 1 17  ? 77.946  90.722  98.114  1.00 55.04 ? 13  LYS H CD  1 
ATOM   101  C CE  . LYS A 1 17  ? 79.411  90.340  97.947  1.00 59.42 ? 13  LYS H CE  1 
ATOM   102  N NZ  . LYS A 1 17  ? 79.931  90.759  96.615  1.00 63.24 ? 13  LYS H NZ  1 
ATOM   103  N N   . ALA A 1 18  ? 73.210  89.578  100.965 1.00 35.21 ? 14  ALA H N   1 
ATOM   104  C CA  . ALA A 1 18  ? 71.781  89.330  100.919 1.00 35.27 ? 14  ALA H CA  1 
ATOM   105  C C   . ALA A 1 18  ? 71.344  89.037  99.480  1.00 35.85 ? 14  ALA H C   1 
ATOM   106  O O   . ALA A 1 18  ? 71.927  89.546  98.522  1.00 37.12 ? 14  ALA H O   1 
ATOM   107  C CB  . ALA A 1 18  ? 71.009  90.502  101.499 1.00 35.32 ? 14  ALA H CB  1 
ATOM   108  N N   . GLY A 1 19  ? 70.370  88.151  99.340  1.00 35.39 ? 15  GLY H N   1 
ATOM   109  C CA  . GLY A 1 19  ? 69.940  87.666  98.036  1.00 34.85 ? 15  GLY H CA  1 
ATOM   110  C C   . GLY A 1 19  ? 70.775  86.530  97.479  1.00 33.83 ? 15  GLY H C   1 
ATOM   111  O O   . GLY A 1 19  ? 70.296  85.780  96.634  1.00 34.59 ? 15  GLY H O   1 
ATOM   112  N N   . ALA A 1 20  ? 72.020  86.396  97.929  1.00 33.40 ? 16  ALA H N   1 
ATOM   113  C CA  . ALA A 1 20  ? 72.887  85.316  97.471  1.00 32.78 ? 16  ALA H CA  1 
ATOM   114  C C   . ALA A 1 20  ? 72.422  83.967  98.005  1.00 32.00 ? 16  ALA H C   1 
ATOM   115  O O   . ALA A 1 20  ? 71.533  83.886  98.852  1.00 31.08 ? 16  ALA H O   1 
ATOM   116  C CB  . ALA A 1 20  ? 74.328  85.577  97.900  1.00 32.67 ? 16  ALA H CB  1 
ATOM   117  N N   . SER A 1 21  ? 73.046  82.919  97.489  1.00 31.84 ? 17  SER H N   1 
ATOM   118  C CA  . SER A 1 21  ? 72.872  81.563  97.977  1.00 32.05 ? 17  SER H CA  1 
ATOM   119  C C   . SER A 1 21  ? 74.189  81.047  98.511  1.00 30.10 ? 17  SER H C   1 
ATOM   120  O O   . SER A 1 21  ? 75.239  81.522  98.115  1.00 30.78 ? 17  SER H O   1 
ATOM   121  C CB  . SER A 1 21  ? 72.425  80.650  96.851  1.00 32.90 ? 17  SER H CB  1 
ATOM   122  O OG  . SER A 1 21  ? 71.123  80.997  96.450  1.00 37.70 ? 17  SER H OG  1 
ATOM   123  N N   . VAL A 1 22  ? 74.119  80.074  99.412  1.00 29.62 ? 18  VAL H N   1 
ATOM   124  C CA  . VAL A 1 22  ? 75.269  79.235  99.763  1.00 28.48 ? 18  VAL H CA  1 
ATOM   125  C C   . VAL A 1 22  ? 74.825  77.799  99.816  1.00 27.73 ? 18  VAL H C   1 
ATOM   126  O O   . VAL A 1 22  ? 73.654  77.503  100.037 1.00 28.68 ? 18  VAL H O   1 
ATOM   127  C CB  . VAL A 1 22  ? 75.907  79.525  101.146 1.00 30.02 ? 18  VAL H CB  1 
ATOM   128  C CG1 . VAL A 1 22  ? 76.655  80.834  101.142 1.00 32.10 ? 18  VAL H CG1 1 
ATOM   129  C CG2 . VAL A 1 22  ? 74.880  79.482  102.274 1.00 29.82 ? 18  VAL H CG2 1 
ATOM   130  N N   . LYS A 1 23  ? 75.807  76.925  99.671  1.00 26.59 ? 19  LYS H N   1 
ATOM   131  C CA  . LYS A 1 23  ? 75.647  75.507  99.790  1.00 26.40 ? 19  LYS H CA  1 
ATOM   132  C C   . LYS A 1 23  ? 76.660  75.005  100.825 1.00 25.95 ? 19  LYS H C   1 
ATOM   133  O O   . LYS A 1 23  ? 77.857  75.088  100.605 1.00 23.96 ? 19  LYS H O   1 
ATOM   134  C CB  . LYS A 1 23  ? 75.906  74.856  98.454  1.00 27.19 ? 19  LYS H CB  1 
ATOM   135  C CG  . LYS A 1 23  ? 75.307  73.480  98.376  1.00 28.15 ? 19  LYS H CG  1 
ATOM   136  C CD  . LYS A 1 23  ? 75.684  72.808  97.082  1.00 28.72 ? 19  LYS H CD  1 
ATOM   137  C CE  . LYS A 1 23  ? 74.871  71.550  96.881  1.00 29.73 ? 19  LYS H CE  1 
ATOM   138  N NZ  . LYS A 1 23  ? 74.969  71.068  95.474  1.00 31.65 ? 19  LYS H NZ  1 
ATOM   139  N N   . LEU A 1 24  ? 76.158  74.502  101.951 1.00 25.32 ? 20  LEU H N   1 
ATOM   140  C CA  . LEU A 1 24  ? 76.993  73.937  103.016 1.00 23.38 ? 20  LEU H CA  1 
ATOM   141  C C   . LEU A 1 24  ? 77.077  72.441  102.816 1.00 22.22 ? 20  LEU H C   1 
ATOM   142  O O   . LEU A 1 24  ? 76.149  71.831  102.292 1.00 22.11 ? 20  LEU H O   1 
ATOM   143  C CB  . LEU A 1 24  ? 76.405  74.252  104.388 1.00 23.20 ? 20  LEU H CB  1 
ATOM   144  C CG  . LEU A 1 24  ? 75.869  75.656  104.647 1.00 23.13 ? 20  LEU H CG  1 
ATOM   145  C CD1 . LEU A 1 24  ? 75.457  75.773  106.109 1.00 22.15 ? 20  LEU H CD1 1 
ATOM   146  C CD2 . LEU A 1 24  ? 76.887  76.737  104.302 1.00 23.52 ? 20  LEU H CD2 1 
ATOM   147  N N   . SER A 1 25  ? 78.192  71.859  103.236 1.00 21.04 ? 21  SER H N   1 
ATOM   148  C CA  . SER A 1 25  ? 78.422  70.430  103.088 1.00 21.30 ? 21  SER H CA  1 
ATOM   149  C C   . SER A 1 25  ? 78.929  69.817  104.395 1.00 21.63 ? 21  SER H C   1 
ATOM   150  O O   . SER A 1 25  ? 79.461  70.519  105.259 1.00 21.19 ? 21  SER H O   1 
ATOM   151  C CB  . SER A 1 25  ? 79.402  70.158  101.953 1.00 21.36 ? 21  SER H CB  1 
ATOM   152  O OG  . SER A 1 25  ? 80.707  70.541  102.305 1.00 19.85 ? 21  SER H OG  1 
ATOM   153  N N   . CYS A 1 26  ? 78.748  68.509  104.509 1.00 22.70 ? 22  CYS H N   1 
ATOM   154  C CA  . CYS A 1 26  ? 79.043  67.756  105.722 1.00 25.05 ? 22  CYS H CA  1 
ATOM   155  C C   . CYS A 1 26  ? 79.517  66.394  105.261 1.00 23.62 ? 22  CYS H C   1 
ATOM   156  O O   . CYS A 1 26  ? 78.728  65.531  104.904 1.00 22.11 ? 22  CYS H O   1 
ATOM   157  C CB  . CYS A 1 26  ? 77.770  67.695  106.590 1.00 29.16 ? 22  CYS H CB  1 
ATOM   158  S SG  . CYS A 1 26  ? 77.591  66.581  108.031 1.00 36.67 ? 22  CYS H SG  1 
ATOM   159  N N   . LYS A 1 27  ? 80.832  66.223  105.221 1.00 25.25 ? 23  LYS H N   1 
ATOM   160  C CA  . LYS A 1 27  ? 81.426  64.966  104.750 1.00 26.62 ? 23  LYS H CA  1 
ATOM   161  C C   . LYS A 1 27  ? 81.471  63.988  105.896 1.00 25.81 ? 23  LYS H C   1 
ATOM   162  O O   . LYS A 1 27  ? 82.037  64.297  106.927 1.00 24.38 ? 23  LYS H O   1 
ATOM   163  C CB  . LYS A 1 27  ? 82.841  65.187  104.194 1.00 28.45 ? 23  LYS H CB  1 
ATOM   164  C CG  . LYS A 1 27  ? 83.579  63.877  103.938 1.00 31.77 ? 23  LYS H CG  1 
ATOM   165  C CD  . LYS A 1 27  ? 84.580  63.921  102.792 1.00 34.09 ? 23  LYS H CD  1 
ATOM   166  C CE  . LYS A 1 27  ? 85.218  62.546  102.572 1.00 35.63 ? 23  LYS H CE  1 
ATOM   167  N NZ  . LYS A 1 27  ? 84.252  61.418  102.340 1.00 37.51 ? 23  LYS H NZ  1 
ATOM   168  N N   . THR A 1 28  ? 80.904  62.801  105.697 1.00 26.74 ? 24  THR H N   1 
ATOM   169  C CA  . THR A 1 28  ? 80.821  61.799  106.749 1.00 26.49 ? 24  THR H CA  1 
ATOM   170  C C   . THR A 1 28  ? 81.760  60.632  106.490 1.00 28.54 ? 24  THR H C   1 
ATOM   171  O O   . THR A 1 28  ? 82.180  60.385  105.362 1.00 29.14 ? 24  THR H O   1 
ATOM   172  C CB  . THR A 1 28  ? 79.386  61.274  106.943 1.00 26.72 ? 24  THR H CB  1 
ATOM   173  O OG1 . THR A 1 28  ? 79.067  60.311  105.940 1.00 28.65 ? 24  THR H OG1 1 
ATOM   174  C CG2 . THR A 1 28  ? 78.365  62.413  106.871 1.00 27.12 ? 24  THR H CG2 1 
ATOM   175  N N   . SER A 1 29  ? 82.053  59.914  107.567 1.00 30.68 ? 25  SER H N   1 
ATOM   176  C CA  . SER A 1 29  ? 82.835  58.687  107.541 1.00 31.57 ? 25  SER H CA  1 
ATOM   177  C C   . SER A 1 29  ? 82.596  57.873  108.807 1.00 32.08 ? 25  SER H C   1 
ATOM   178  O O   . SER A 1 29  ? 82.082  58.381  109.818 1.00 31.31 ? 25  SER H O   1 
ATOM   179  C CB  . SER A 1 29  ? 84.318  59.018  107.445 1.00 33.02 ? 25  SER H CB  1 
ATOM   180  O OG  . SER A 1 29  ? 84.714  59.830  108.540 1.00 34.89 ? 25  SER H OG  1 
ATOM   181  N N   . GLY A 1 30  ? 82.988  56.607  108.745 1.00 32.99 ? 26  GLY H N   1 
ATOM   182  C CA  . GLY A 1 30  ? 83.001  55.731  109.915 1.00 31.88 ? 26  GLY H CA  1 
ATOM   183  C C   . GLY A 1 30  ? 81.689  55.044  110.187 1.00 33.96 ? 26  GLY H C   1 
ATOM   184  O O   . GLY A 1 30  ? 81.507  54.450  111.250 1.00 36.04 ? 26  GLY H O   1 
ATOM   185  N N   . TYR A 1 31  ? 80.764  55.132  109.237 1.00 34.60 ? 27  TYR H N   1 
ATOM   186  C CA  . TYR A 1 31  ? 79.510  54.407  109.294 1.00 33.14 ? 27  TYR H CA  1 
ATOM   187  C C   . TYR A 1 31  ? 78.961  54.270  107.872 1.00 34.78 ? 27  TYR H C   1 
ATOM   188  O O   . TYR A 1 31  ? 79.426  54.949  106.949 1.00 34.03 ? 27  TYR H O   1 
ATOM   189  C CB  . TYR A 1 31  ? 78.524  55.101  110.243 1.00 33.99 ? 27  TYR H CB  1 
ATOM   190  C CG  . TYR A 1 31  ? 77.866  56.350  109.713 1.00 33.74 ? 27  TYR H CG  1 
ATOM   191  C CD1 . TYR A 1 31  ? 78.460  57.608  109.866 1.00 33.88 ? 27  TYR H CD1 1 
ATOM   192  C CD2 . TYR A 1 31  ? 76.634  56.276  109.074 1.00 33.99 ? 27  TYR H CD2 1 
ATOM   193  C CE1 . TYR A 1 31  ? 77.839  58.750  109.372 1.00 33.34 ? 27  TYR H CE1 1 
ATOM   194  C CE2 . TYR A 1 31  ? 76.006  57.405  108.585 1.00 33.62 ? 27  TYR H CE2 1 
ATOM   195  C CZ  . TYR A 1 31  ? 76.609  58.640  108.737 1.00 33.34 ? 27  TYR H CZ  1 
ATOM   196  O OH  . TYR A 1 31  ? 75.964  59.751  108.239 1.00 32.22 ? 27  TYR H OH  1 
ATOM   197  N N   . THR A 1 32  ? 77.986  53.385  107.701 1.00 35.00 ? 28  THR H N   1 
ATOM   198  C CA  . THR A 1 32  ? 77.402  53.137  106.384 1.00 36.76 ? 28  THR H CA  1 
ATOM   199  C C   . THR A 1 32  ? 76.458  54.288  106.018 1.00 34.05 ? 28  THR H C   1 
ATOM   200  O O   . THR A 1 32  ? 75.304  54.302  106.414 1.00 35.21 ? 28  THR H O   1 
ATOM   201  C CB  . THR A 1 32  ? 76.651  51.784  106.339 1.00 39.31 ? 28  THR H CB  1 
ATOM   202  O OG1 . THR A 1 32  ? 77.433  50.798  107.012 1.00 41.46 ? 28  THR H OG1 1 
ATOM   203  C CG2 . THR A 1 32  ? 76.405  51.341  104.891 1.00 39.21 ? 28  THR H CG2 1 
ATOM   204  N N   . PHE A 1 33  ? 76.975  55.239  105.253 1.00 33.40 ? 29  PHE H N   1 
ATOM   205  C CA  . PHE A 1 33  ? 76.281  56.475  104.924 1.00 34.56 ? 29  PHE H CA  1 
ATOM   206  C C   . PHE A 1 33  ? 74.817  56.261  104.523 1.00 38.38 ? 29  PHE H C   1 
ATOM   207  O O   . PHE A 1 33  ? 73.927  56.961  105.021 1.00 37.16 ? 29  PHE H O   1 
ATOM   208  C CB  . PHE A 1 33  ? 77.044  57.189  103.806 1.00 34.25 ? 29  PHE H CB  1 
ATOM   209  C CG  . PHE A 1 33  ? 76.445  58.508  103.387 1.00 33.08 ? 29  PHE H CG  1 
ATOM   210  C CD1 . PHE A 1 33  ? 76.475  59.600  104.239 1.00 32.57 ? 29  PHE H CD1 1 
ATOM   211  C CD2 . PHE A 1 33  ? 75.877  58.664  102.130 1.00 32.54 ? 29  PHE H CD2 1 
ATOM   212  C CE1 . PHE A 1 33  ? 75.939  60.821  103.852 1.00 31.82 ? 29  PHE H CE1 1 
ATOM   213  C CE2 . PHE A 1 33  ? 75.341  59.879  101.738 1.00 31.40 ? 29  PHE H CE2 1 
ATOM   214  C CZ  . PHE A 1 33  ? 75.371  60.958  102.600 1.00 31.66 ? 29  PHE H CZ  1 
ATOM   215  N N   . ASN A 1 34  ? 74.571  55.264  103.675 1.00 38.61 ? 30  ASN H N   1 
ATOM   216  C CA  . ASN A 1 34  ? 73.236  55.061  103.097 1.00 40.30 ? 30  ASN H CA  1 
ATOM   217  C C   . ASN A 1 34  ? 72.131  54.576  104.055 1.00 39.44 ? 30  ASN H C   1 
ATOM   218  O O   . ASN A 1 34  ? 70.953  54.642  103.706 1.00 37.82 ? 30  ASN H O   1 
ATOM   219  C CB  . ASN A 1 34  ? 73.313  54.121  101.881 1.00 40.90 ? 30  ASN H CB  1 
ATOM   220  C CG  . ASN A 1 34  ? 72.276  54.453  100.821 1.00 43.34 ? 30  ASN H CG  1 
ATOM   221  O OD1 . ASN A 1 34  ? 72.049  55.626  100.498 1.00 46.53 ? 30  ASN H OD1 1 
ATOM   222  N ND2 . ASN A 1 34  ? 71.641  53.426  100.268 1.00 44.33 ? 30  ASN H ND2 1 
ATOM   223  N N   . ASN A 1 35  ? 72.507  54.095  105.238 1.00 38.44 ? 31  ASN H N   1 
ATOM   224  C CA  . ASN A 1 35  ? 71.558  53.470  106.171 1.00 39.40 ? 31  ASN H CA  1 
ATOM   225  C C   . ASN A 1 35  ? 71.008  54.337  107.309 1.00 37.21 ? 31  ASN H C   1 
ATOM   226  O O   . ASN A 1 35  ? 70.241  53.844  108.140 1.00 34.71 ? 31  ASN H O   1 
ATOM   227  C CB  . ASN A 1 35  ? 72.224  52.244  106.788 1.00 40.36 ? 31  ASN H CB  1 
ATOM   228  C CG  . ASN A 1 35  ? 72.720  51.251  105.746 1.00 42.84 ? 31  ASN H CG  1 
ATOM   229  O OD1 . ASN A 1 35  ? 72.421  51.370  104.558 1.00 45.06 ? 31  ASN H OD1 1 
ATOM   230  N ND2 . ASN A 1 35  ? 73.482  50.258  106.196 1.00 43.90 ? 31  ASN H ND2 1 
ATOM   231  N N   . TYR A 1 36  ? 71.408  55.607  107.372 1.00 36.66 ? 32  TYR H N   1 
ATOM   232  C CA  . TYR A 1 36  ? 70.958  56.501  108.455 1.00 35.59 ? 32  TYR H CA  1 
ATOM   233  C C   . TYR A 1 36  ? 70.646  57.879  107.952 1.00 32.58 ? 32  TYR H C   1 
ATOM   234  O O   . TYR A 1 36  ? 71.301  58.387  107.044 1.00 35.35 ? 32  TYR H O   1 
ATOM   235  C CB  . TYR A 1 36  ? 71.988  56.605  109.571 1.00 36.76 ? 32  TYR H CB  1 
ATOM   236  C CG  . TYR A 1 36  ? 72.400  55.276  110.131 1.00 38.83 ? 32  TYR H CG  1 
ATOM   237  C CD1 . TYR A 1 36  ? 71.682  54.672  111.166 1.00 40.00 ? 32  TYR H CD1 1 
ATOM   238  C CD2 . TYR A 1 36  ? 73.509  54.604  109.611 1.00 40.49 ? 32  TYR H CD2 1 
ATOM   239  C CE1 . TYR A 1 36  ? 72.073  53.436  111.672 1.00 41.18 ? 32  TYR H CE1 1 
ATOM   240  C CE2 . TYR A 1 36  ? 73.906  53.370  110.107 1.00 40.44 ? 32  TYR H CE2 1 
ATOM   241  C CZ  . TYR A 1 36  ? 73.187  52.787  111.134 1.00 41.14 ? 32  TYR H CZ  1 
ATOM   242  O OH  . TYR A 1 36  ? 73.586  51.560  111.620 1.00 40.43 ? 32  TYR H OH  1 
ATOM   243  N N   . TRP A 1 37  ? 69.648  58.495  108.567 1.00 29.51 ? 33  TRP H N   1 
ATOM   244  C CA  . TRP A 1 37  ? 69.152  59.782  108.119 1.00 27.73 ? 33  TRP H CA  1 
ATOM   245  C C   . TRP A 1 37  ? 70.082  60.870  108.604 1.00 25.28 ? 33  TRP H C   1 
ATOM   246  O O   . TRP A 1 37  ? 70.846  60.671  109.539 1.00 23.90 ? 33  TRP H O   1 
ATOM   247  C CB  . TRP A 1 37  ? 67.757  60.049  108.657 1.00 28.14 ? 33  TRP H CB  1 
ATOM   248  C CG  . TRP A 1 37  ? 66.701  59.103  108.145 1.00 29.52 ? 33  TRP H CG  1 
ATOM   249  C CD1 . TRP A 1 37  ? 66.762  57.738  108.100 1.00 30.76 ? 33  TRP H CD1 1 
ATOM   250  C CD2 . TRP A 1 37  ? 65.420  59.457  107.642 1.00 28.27 ? 33  TRP H CD2 1 
ATOM   251  N NE1 . TRP A 1 37  ? 65.613  57.229  107.586 1.00 30.58 ? 33  TRP H NE1 1 
ATOM   252  C CE2 . TRP A 1 37  ? 64.763  58.258  107.301 1.00 29.19 ? 33  TRP H CE2 1 
ATOM   253  C CE3 . TRP A 1 37  ? 64.765  60.675  107.430 1.00 28.33 ? 33  TRP H CE3 1 
ATOM   254  C CZ2 . TRP A 1 37  ? 63.477  58.233  106.767 1.00 28.63 ? 33  TRP H CZ2 1 
ATOM   255  C CZ3 . TRP A 1 37  ? 63.486  60.653  106.900 1.00 29.31 ? 33  TRP H CZ3 1 
ATOM   256  C CH2 . TRP A 1 37  ? 62.852  59.437  106.577 1.00 28.70 ? 33  TRP H CH2 1 
ATOM   257  N N   . ILE A 1 38  ? 69.994  62.023  107.957 1.00 24.02 ? 34  ILE H N   1 
ATOM   258  C CA  . ILE A 1 38  ? 70.844  63.167  108.265 1.00 23.20 ? 34  ILE H CA  1 
ATOM   259  C C   . ILE A 1 38  ? 69.927  64.347  108.530 1.00 20.79 ? 34  ILE H C   1 
ATOM   260  O O   . ILE A 1 38  ? 68.940  64.557  107.821 1.00 21.09 ? 34  ILE H O   1 
ATOM   261  C CB  . ILE A 1 38  ? 71.795  63.508  107.095 1.00 25.21 ? 34  ILE H CB  1 
ATOM   262  C CG1 . ILE A 1 38  ? 72.699  62.298  106.748 1.00 26.35 ? 34  ILE H CG1 1 
ATOM   263  C CG2 . ILE A 1 38  ? 72.604  64.771  107.404 1.00 24.70 ? 34  ILE H CG2 1 
ATOM   264  C CD1 . ILE A 1 38  ? 74.125  62.369  107.252 1.00 27.64 ? 34  ILE H CD1 1 
ATOM   265  N N   . HIS A 1 39  ? 70.274  65.116  109.551 1.00 17.72 ? 35  HIS H N   1 
ATOM   266  C CA  . HIS A 1 39  ? 69.503  66.250  109.964 1.00 16.92 ? 35  HIS H CA  1 
ATOM   267  C C   . HIS A 1 39  ? 70.362  67.488  109.933 1.00 15.91 ? 35  HIS H C   1 
ATOM   268  O O   . HIS A 1 39  ? 71.575  67.410  110.148 1.00 14.12 ? 35  HIS H O   1 
ATOM   269  C CB  . HIS A 1 39  ? 69.031  66.058  111.398 1.00 17.14 ? 35  HIS H CB  1 
ATOM   270  C CG  . HIS A 1 39  ? 68.212  64.827  111.617 1.00 16.90 ? 35  HIS H CG  1 
ATOM   271  N ND1 . HIS A 1 39  ? 66.845  64.835  111.554 1.00 16.79 ? 35  HIS H ND1 1 
ATOM   272  C CD2 . HIS A 1 39  ? 68.557  63.560  111.935 1.00 18.31 ? 35  HIS H CD2 1 
ATOM   273  C CE1 . HIS A 1 39  ? 66.373  63.630  111.796 1.00 16.72 ? 35  HIS H CE1 1 
ATOM   274  N NE2 . HIS A 1 39  ? 67.390  62.834  112.037 1.00 17.64 ? 35  HIS H NE2 1 
ATOM   275  N N   . TRP A 1 40  ? 69.721  68.628  109.691 1.00 14.95 ? 36  TRP H N   1 
ATOM   276  C CA  . TRP A 1 40  ? 70.376  69.906  109.838 1.00 15.03 ? 36  TRP H CA  1 
ATOM   277  C C   . TRP A 1 40  ? 69.661  70.760  110.874 1.00 14.91 ? 36  TRP H C   1 
ATOM   278  O O   . TRP A 1 40  ? 68.429  70.764  110.964 1.00 13.80 ? 36  TRP H O   1 
ATOM   279  C CB  . TRP A 1 40  ? 70.480  70.644  108.507 1.00 15.40 ? 36  TRP H CB  1 
ATOM   280  C CG  . TRP A 1 40  ? 71.375  69.960  107.503 1.00 16.05 ? 36  TRP H CG  1 
ATOM   281  C CD1 . TRP A 1 40  ? 71.070  68.869  106.783 1.00 16.71 ? 36  TRP H CD1 1 
ATOM   282  C CD2 . TRP A 1 40  ? 72.713  70.324  107.137 1.00 16.92 ? 36  TRP H CD2 1 
ATOM   283  N NE1 . TRP A 1 40  ? 72.114  68.521  105.961 1.00 17.24 ? 36  TRP H NE1 1 
ATOM   284  C CE2 . TRP A 1 40  ? 73.132  69.412  106.144 1.00 17.35 ? 36  TRP H CE2 1 
ATOM   285  C CE3 . TRP A 1 40  ? 73.581  71.351  107.521 1.00 17.09 ? 36  TRP H CE3 1 
ATOM   286  C CZ2 . TRP A 1 40  ? 74.390  69.476  105.539 1.00 17.55 ? 36  TRP H CZ2 1 
ATOM   287  C CZ3 . TRP A 1 40  ? 74.851  71.419  106.909 1.00 17.55 ? 36  TRP H CZ3 1 
ATOM   288  C CH2 . TRP A 1 40  ? 75.233  70.482  105.932 1.00 17.34 ? 36  TRP H CH2 1 
ATOM   289  N N   . VAL A 1 41  ? 70.473  71.513  111.620 1.00 14.77 ? 37  VAL H N   1 
ATOM   290  C CA  . VAL A 1 41  ? 70.030  72.323  112.729 1.00 14.71 ? 37  VAL H CA  1 
ATOM   291  C C   . VAL A 1 41  ? 70.639  73.710  112.602 1.00 14.58 ? 37  VAL H C   1 
ATOM   292  O O   . VAL A 1 41  ? 71.802  73.847  112.269 1.00 14.25 ? 37  VAL H O   1 
ATOM   293  C CB  . VAL A 1 41  ? 70.426  71.651  114.062 1.00 14.86 ? 37  VAL H CB  1 
ATOM   294  C CG1 . VAL A 1 41  ? 70.198  72.572  115.265 1.00 15.23 ? 37  VAL H CG1 1 
ATOM   295  C CG2 . VAL A 1 41  ? 69.652  70.361  114.243 1.00 14.82 ? 37  VAL H CG2 1 
ATOM   296  N N   . LYS A 1 42  ? 69.825  74.728  112.857 1.00 14.92 ? 38  LYS H N   1 
ATOM   297  C CA  . LYS A 1 42  ? 70.275  76.109  112.919 1.00 15.52 ? 38  LYS H CA  1 
ATOM   298  C C   . LYS A 1 42  ? 70.383  76.549  114.375 1.00 15.09 ? 38  LYS H C   1 
ATOM   299  O O   . LYS A 1 42  ? 69.552  76.181  115.196 1.00 14.88 ? 38  LYS H O   1 
ATOM   300  C CB  . LYS A 1 42  ? 69.289  77.011  112.187 1.00 16.13 ? 38  LYS H CB  1 
ATOM   301  C CG  . LYS A 1 42  ? 69.604  78.508  112.201 1.00 16.74 ? 38  LYS H CG  1 
ATOM   302  C CD  . LYS A 1 42  ? 68.497  79.259  111.474 1.00 17.23 ? 38  LYS H CD  1 
ATOM   303  C CE  . LYS A 1 42  ? 68.756  80.739  111.410 1.00 18.37 ? 38  LYS H CE  1 
ATOM   304  N NZ  . LYS A 1 42  ? 67.631  81.414  110.694 1.00 19.06 ? 38  LYS H NZ  1 
ATOM   305  N N   . GLN A 1 43  ? 71.398  77.356  114.658 1.00 15.36 ? 39  GLN H N   1 
ATOM   306  C CA  . GLN A 1 43  ? 71.600  77.978  115.964 1.00 15.70 ? 39  GLN H CA  1 
ATOM   307  C C   . GLN A 1 43  ? 71.901  79.450  115.773 1.00 16.82 ? 39  GLN H C   1 
ATOM   308  O O   . GLN A 1 43  ? 72.894  79.817  115.154 1.00 16.26 ? 39  GLN H O   1 
ATOM   309  C CB  . GLN A 1 43  ? 72.742  77.329  116.749 1.00 15.55 ? 39  GLN H CB  1 
ATOM   310  C CG  . GLN A 1 43  ? 72.726  77.793  118.202 1.00 15.21 ? 39  GLN H CG  1 
ATOM   311  C CD  . GLN A 1 43  ? 73.663  77.041  119.113 1.00 15.01 ? 39  GLN H CD  1 
ATOM   312  O OE1 . GLN A 1 43  ? 74.690  76.537  118.685 1.00 13.84 ? 39  GLN H OE1 1 
ATOM   313  N NE2 . GLN A 1 43  ? 73.311  76.983  120.413 1.00 15.34 ? 39  GLN H NE2 1 
ATOM   314  N N   . SER A 1 44  ? 71.035  80.298  116.311 1.00 19.19 ? 40  SER H N   1 
ATOM   315  C CA  . SER A 1 44  ? 71.093  81.740  116.069 1.00 19.83 ? 40  SER H CA  1 
ATOM   316  C C   . SER A 1 44  ? 70.767  82.436  117.368 1.00 21.80 ? 40  SER H C   1 
ATOM   317  O O   . SER A 1 44  ? 69.983  81.913  118.152 1.00 22.06 ? 40  SER H O   1 
ATOM   318  C CB  . SER A 1 44  ? 70.068  82.149  115.007 1.00 20.21 ? 40  SER H CB  1 
ATOM   319  O OG  . SER A 1 44  ? 68.736  82.101  115.513 1.00 19.37 ? 40  SER H OG  1 
ATOM   320  N N   . PRO A 1 45  ? 71.346  83.630  117.602 1.00 24.25 ? 41  PRO H N   1 
ATOM   321  C CA  . PRO A 1 45  ? 71.043  84.358  118.841 1.00 25.53 ? 41  PRO H CA  1 
ATOM   322  C C   . PRO A 1 45  ? 69.552  84.661  119.000 1.00 25.90 ? 41  PRO H C   1 
ATOM   323  O O   . PRO A 1 45  ? 69.025  84.602  120.113 1.00 27.50 ? 41  PRO H O   1 
ATOM   324  C CB  . PRO A 1 45  ? 71.817  85.680  118.684 1.00 25.28 ? 41  PRO H CB  1 
ATOM   325  C CG  . PRO A 1 45  ? 72.762  85.459  117.567 1.00 24.60 ? 41  PRO H CG  1 
ATOM   326  C CD  . PRO A 1 45  ? 72.134  84.454  116.669 1.00 24.46 ? 41  PRO H CD  1 
ATOM   327  N N   . GLY A 1 46  ? 68.902  84.979  117.883 1.00 25.53 ? 42  GLY H N   1 
ATOM   328  C CA  . GLY A 1 46  ? 67.492  85.323  117.861 1.00 26.73 ? 42  GLY H CA  1 
ATOM   329  C C   . GLY A 1 46  ? 66.504  84.207  118.153 1.00 26.63 ? 42  GLY H C   1 
ATOM   330  O O   . GLY A 1 46  ? 65.471  84.454  118.773 1.00 27.81 ? 42  GLY H O   1 
ATOM   331  N N   . GLN A 1 47  ? 66.779  82.999  117.670 1.00 25.78 ? 43  GLN H N   1 
ATOM   332  C CA  . GLN A 1 47  ? 65.827  81.870  117.797 1.00 25.40 ? 43  GLN H CA  1 
ATOM   333  C C   . GLN A 1 47  ? 66.384  80.652  118.509 1.00 22.73 ? 43  GLN H C   1 
ATOM   334  O O   . GLN A 1 47  ? 65.694  79.639  118.609 1.00 23.82 ? 43  GLN H O   1 
ATOM   335  C CB  . GLN A 1 47  ? 65.383  81.414  116.407 1.00 28.49 ? 43  GLN H CB  1 
ATOM   336  C CG  . GLN A 1 47  ? 64.802  82.489  115.522 1.00 30.19 ? 43  GLN H CG  1 
ATOM   337  C CD  . GLN A 1 47  ? 63.535  83.062  116.095 1.00 33.79 ? 43  GLN H CD  1 
ATOM   338  O OE1 . GLN A 1 47  ? 62.650  82.327  116.531 1.00 33.87 ? 43  GLN H OE1 1 
ATOM   339  N NE2 . GLN A 1 47  ? 63.438  84.391  116.106 1.00 38.47 ? 43  GLN H NE2 1 
ATOM   340  N N   . GLY A 1 48  ? 67.616  80.728  118.995 1.00 20.24 ? 44  GLY H N   1 
ATOM   341  C CA  . GLY A 1 48  ? 68.252  79.573  119.613 1.00 19.48 ? 44  GLY H CA  1 
ATOM   342  C C   . GLY A 1 48  ? 68.413  78.452  118.595 1.00 18.70 ? 44  GLY H C   1 
ATOM   343  O O   . GLY A 1 48  ? 68.743  78.721  117.431 1.00 18.44 ? 44  GLY H O   1 
ATOM   344  N N   . LEU A 1 49  ? 68.131  77.219  119.032 1.00 16.73 ? 45  LEU H N   1 
ATOM   345  C CA  . LEU A 1 49  ? 68.318  76.025  118.219 1.00 16.26 ? 45  LEU H CA  1 
ATOM   346  C C   . LEU A 1 49  ? 67.020  75.648  117.505 1.00 15.99 ? 45  LEU H C   1 
ATOM   347  O O   . LEU A 1 49  ? 65.982  75.563  118.129 1.00 14.81 ? 45  LEU H O   1 
ATOM   348  C CB  . LEU A 1 49  ? 68.771  74.840  119.066 1.00 15.78 ? 45  LEU H CB  1 
ATOM   349  C CG  . LEU A 1 49  ? 70.244  74.796  119.486 1.00 15.89 ? 45  LEU H CG  1 
ATOM   350  C CD1 . LEU A 1 49  ? 70.426  73.890  120.693 1.00 16.15 ? 45  LEU H CD1 1 
ATOM   351  C CD2 . LEU A 1 49  ? 71.133  74.327  118.347 1.00 15.87 ? 45  LEU H CD2 1 
ATOM   352  N N   . GLU A 1 50  ? 67.104  75.396  116.203 1.00 16.79 ? 46  GLU H N   1 
ATOM   353  C CA  . GLU A 1 50  ? 65.951  74.970  115.422 1.00 18.35 ? 46  GLU H CA  1 
ATOM   354  C C   . GLU A 1 50  ? 66.348  73.829  114.511 1.00 18.56 ? 46  GLU H C   1 
ATOM   355  O O   . GLU A 1 50  ? 67.411  73.860  113.873 1.00 19.38 ? 46  GLU H O   1 
ATOM   356  C CB  . GLU A 1 50  ? 65.391  76.109  114.578 1.00 19.57 ? 46  GLU H CB  1 
ATOM   357  C CG  . GLU A 1 50  ? 64.988  77.352  115.363 1.00 20.53 ? 46  GLU H CG  1 
ATOM   358  C CD  . GLU A 1 50  ? 64.727  78.516  114.451 1.00 22.56 ? 46  GLU H CD  1 
ATOM   359  O OE1 . GLU A 1 50  ? 65.717  79.092  113.943 1.00 26.52 ? 46  GLU H OE1 1 
ATOM   360  O OE2 . GLU A 1 50  ? 63.550  78.838  114.214 1.00 21.81 ? 46  GLU H OE2 1 
ATOM   361  N N   . TRP A 1 51  ? 65.486  72.827  114.468 1.00 17.86 ? 47  TRP H N   1 
ATOM   362  C CA  . TRP A 1 51  ? 65.602  71.738  113.525 1.00 18.15 ? 47  TRP H CA  1 
ATOM   363  C C   . TRP A 1 51  ? 65.096  72.206  112.154 1.00 17.23 ? 47  TRP H C   1 
ATOM   364  O O   . TRP A 1 51  ? 63.999  72.750  112.033 1.00 16.98 ? 47  TRP H O   1 
ATOM   365  C CB  . TRP A 1 51  ? 64.802  70.556  114.042 1.00 18.77 ? 47  TRP H CB  1 
ATOM   366  C CG  . TRP A 1 51  ? 64.790  69.397  113.124 1.00 19.57 ? 47  TRP H CG  1 
ATOM   367  C CD1 . TRP A 1 51  ? 65.774  68.492  112.945 1.00 19.65 ? 47  TRP H CD1 1 
ATOM   368  C CD2 . TRP A 1 51  ? 63.719  69.017  112.251 1.00 19.42 ? 47  TRP H CD2 1 
ATOM   369  N NE1 . TRP A 1 51  ? 65.398  67.569  111.995 1.00 19.22 ? 47  TRP H NE1 1 
ATOM   370  C CE2 . TRP A 1 51  ? 64.140  67.874  111.550 1.00 20.03 ? 47  TRP H CE2 1 
ATOM   371  C CE3 . TRP A 1 51  ? 62.455  69.552  111.977 1.00 19.84 ? 47  TRP H CE3 1 
ATOM   372  C CZ2 . TRP A 1 51  ? 63.326  67.227  110.611 1.00 20.07 ? 47  TRP H CZ2 1 
ATOM   373  C CZ3 . TRP A 1 51  ? 61.647  68.916  111.039 1.00 19.69 ? 47  TRP H CZ3 1 
ATOM   374  C CH2 . TRP A 1 51  ? 62.086  67.769  110.369 1.00 19.55 ? 47  TRP H CH2 1 
ATOM   375  N N   . ILE A 1 52  ? 65.934  72.028  111.136 1.00 17.13 ? 48  ILE H N   1 
ATOM   376  C CA  . ILE A 1 52  ? 65.642  72.491  109.789 1.00 16.13 ? 48  ILE H CA  1 
ATOM   377  C C   . ILE A 1 52  ? 64.918  71.405  109.021 1.00 16.08 ? 48  ILE H C   1 
ATOM   378  O O   . ILE A 1 52  ? 63.890  71.664  108.429 1.00 16.01 ? 48  ILE H O   1 
ATOM   379  C CB  . ILE A 1 52  ? 66.912  72.901  109.015 1.00 15.81 ? 48  ILE H CB  1 
ATOM   380  C CG1 . ILE A 1 52  ? 67.538  74.139  109.649 1.00 15.60 ? 48  ILE H CG1 1 
ATOM   381  C CG2 . ILE A 1 52  ? 66.583  73.217  107.555 1.00 15.67 ? 48  ILE H CG2 1 
ATOM   382  C CD1 . ILE A 1 52  ? 68.935  74.426  109.155 1.00 15.25 ? 48  ILE H CD1 1 
ATOM   383  N N   . GLY A 1 53  ? 65.483  70.209  109.000 1.00 16.69 ? 49  GLY H N   1 
ATOM   384  C CA  . GLY A 1 53  ? 64.958  69.136  108.169 1.00 17.49 ? 49  GLY H CA  1 
ATOM   385  C C   . GLY A 1 53  ? 65.774  67.872  108.275 1.00 18.04 ? 49  GLY H C   1 
ATOM   386  O O   . GLY A 1 53  ? 66.844  67.861  108.901 1.00 17.94 ? 49  GLY H O   1 
ATOM   387  N N   . GLU A 1 54  ? 65.248  66.813  107.664 1.00 19.38 ? 50  GLU H N   1 
ATOM   388  C CA  . GLU A 1 54  ? 65.877  65.496  107.625 1.00 20.97 ? 50  GLU H CA  1 
ATOM   389  C C   . GLU A 1 54  ? 65.840  64.905  106.215 1.00 21.32 ? 50  GLU H C   1 
ATOM   390  O O   . GLU A 1 54  ? 64.934  65.184  105.452 1.00 21.59 ? 50  GLU H O   1 
ATOM   391  C CB  . GLU A 1 54  ? 65.186  64.541  108.589 1.00 21.90 ? 50  GLU H CB  1 
ATOM   392  C CG  . GLU A 1 54  ? 63.721  64.303  108.294 1.00 23.52 ? 50  GLU H CG  1 
ATOM   393  C CD  . GLU A 1 54  ? 62.979  63.534  109.380 1.00 26.26 ? 50  GLU H CD  1 
ATOM   394  O OE1 . GLU A 1 54  ? 61.752  63.401  109.235 1.00 27.27 ? 50  GLU H OE1 1 
ATOM   395  O OE2 . GLU A 1 54  ? 63.590  63.066  110.371 1.00 28.04 ? 50  GLU H OE2 1 
ATOM   396  N N   . ILE A 1 55  ? 66.831  64.078  105.895 1.00 22.50 ? 51  ILE H N   1 
ATOM   397  C CA  . ILE A 1 55  ? 66.934  63.446  104.583 1.00 22.43 ? 51  ILE H CA  1 
ATOM   398  C C   . ILE A 1 55  ? 67.386  62.017  104.783 1.00 22.67 ? 51  ILE H C   1 
ATOM   399  O O   . ILE A 1 55  ? 68.279  61.733  105.598 1.00 21.20 ? 51  ILE H O   1 
ATOM   400  C CB  . ILE A 1 55  ? 67.866  64.221  103.609 1.00 23.60 ? 51  ILE H CB  1 
ATOM   401  C CG1 . ILE A 1 55  ? 67.953  63.521  102.235 1.00 23.25 ? 51  ILE H CG1 1 
ATOM   402  C CG2 . ILE A 1 55  ? 69.263  64.403  104.184 1.00 23.54 ? 51  ILE H CG2 1 
ATOM   403  C CD1 . ILE A 1 55  ? 68.234  64.454  101.073 1.00 22.93 ? 51  ILE H CD1 1 
ATOM   404  N N   . ASP A 1 56  ? 66.721  61.116  104.073 1.00 22.73 ? 52  ASP H N   1 
ATOM   405  C CA  . ASP A 1 56  ? 67.113  59.711  103.990 1.00 24.63 ? 52  ASP H CA  1 
ATOM   406  C C   . ASP A 1 56  ? 68.003  59.531  102.722 1.00 25.83 ? 52  ASP H C   1 
ATOM   407  O O   . ASP A 1 56  ? 67.502  59.574  101.611 1.00 25.37 ? 52  ASP H O   1 
ATOM   408  C CB  . ASP A 1 56  ? 65.851  58.862  103.885 1.00 24.51 ? 52  ASP H CB  1 
ATOM   409  C CG  . ASP A 1 56  ? 66.126  57.393  103.941 1.00 26.33 ? 52  ASP H CG  1 
ATOM   410  O OD1 . ASP A 1 56  ? 67.278  56.972  103.706 1.00 27.05 ? 52  ASP H OD1 1 
ATOM   411  O OD2 . ASP A 1 56  ? 65.165  56.642  104.219 1.00 27.85 ? 52  ASP H OD2 1 
ATOM   412  N N   . PRO A 1 57  A 69.321  59.347  102.884 1.00 28.82 ? 52  PRO H N   1 
ATOM   413  C CA  . PRO A 1 57  A 70.125  59.165  101.657 1.00 30.94 ? 52  PRO H CA  1 
ATOM   414  C C   . PRO A 1 57  A 69.754  57.934  100.816 1.00 32.75 ? 52  PRO H C   1 
ATOM   415  O O   . PRO A 1 57  A 69.917  57.985  99.602  1.00 36.34 ? 52  PRO H O   1 
ATOM   416  C CB  . PRO A 1 57  A 71.553  59.052  102.179 1.00 29.29 ? 52  PRO H CB  1 
ATOM   417  C CG  . PRO A 1 57  A 71.409  58.659  103.604 1.00 29.88 ? 52  PRO H CG  1 
ATOM   418  C CD  . PRO A 1 57  A 70.167  59.334  104.086 1.00 29.59 ? 52  PRO H CD  1 
ATOM   419  N N   . SER A 1 58  ? 69.240  56.870  101.444 1.00 32.89 ? 53  SER H N   1 
ATOM   420  C CA  . SER A 1 58  ? 68.860  55.640  100.734 1.00 33.03 ? 53  SER H CA  1 
ATOM   421  C C   . SER A 1 58  ? 67.997  55.896  99.501  1.00 34.48 ? 53  SER H C   1 
ATOM   422  O O   . SER A 1 58  ? 68.222  55.289  98.450  1.00 35.65 ? 53  SER H O   1 
ATOM   423  C CB  . SER A 1 58  ? 68.159  54.649  101.664 1.00 31.47 ? 53  SER H CB  1 
ATOM   424  O OG  . SER A 1 58  ? 66.824  55.030  101.904 1.00 32.42 ? 53  SER H OG  1 
ATOM   425  N N   . ASP A 1 59  ? 67.018  56.790  99.642  1.00 33.49 ? 54  ASP H N   1 
ATOM   426  C CA  . ASP A 1 59  ? 66.118  57.141  98.538  1.00 32.59 ? 54  ASP H CA  1 
ATOM   427  C C   . ASP A 1 59  ? 65.943  58.646  98.287  1.00 31.76 ? 54  ASP H C   1 
ATOM   428  O O   . ASP A 1 59  ? 65.099  59.059  97.478  1.00 34.10 ? 54  ASP H O   1 
ATOM   429  C CB  . ASP A 1 59  ? 64.750  56.481  98.761  1.00 32.89 ? 54  ASP H CB  1 
ATOM   430  C CG  . ASP A 1 59  ? 64.079  56.927  100.034 1.00 33.47 ? 54  ASP H CG  1 
ATOM   431  O OD1 . ASP A 1 59  ? 64.556  57.886  100.687 1.00 34.55 ? 54  ASP H OD1 1 
ATOM   432  O OD2 . ASP A 1 59  ? 63.063  56.299  100.398 1.00 33.13 ? 54  ASP H OD2 1 
ATOM   433  N N   . GLY A 1 60  ? 66.729  59.468  98.970  1.00 28.80 ? 55  GLY H N   1 
ATOM   434  C CA  . GLY A 1 60  ? 66.587  60.915  98.864  1.00 29.24 ? 55  GLY H CA  1 
ATOM   435  C C   . GLY A 1 60  ? 65.316  61.524  99.435  1.00 27.26 ? 55  GLY H C   1 
ATOM   436  O O   . GLY A 1 60  ? 65.069  62.697  99.249  1.00 27.49 ? 55  GLY H O   1 
ATOM   437  N N   . TYR A 1 61  ? 64.519  60.744  100.157 1.00 27.15 ? 56  TYR H N   1 
ATOM   438  C CA  . TYR A 1 61  ? 63.318  61.258  100.778 1.00 26.20 ? 56  TYR H CA  1 
ATOM   439  C C   . TYR A 1 61  ? 63.734  62.306  101.796 1.00 25.85 ? 56  TYR H C   1 
ATOM   440  O O   . TYR A 1 61  ? 64.697  62.120  102.529 1.00 23.66 ? 56  TYR H O   1 
ATOM   441  C CB  . TYR A 1 61  ? 62.583  60.142  101.508 1.00 27.02 ? 56  TYR H CB  1 
ATOM   442  C CG  . TYR A 1 61  ? 61.337  60.611  102.195 1.00 28.12 ? 56  TYR H CG  1 
ATOM   443  C CD1 . TYR A 1 61  ? 60.133  60.702  101.497 1.00 30.32 ? 56  TYR H CD1 1 
ATOM   444  C CD2 . TYR A 1 61  ? 61.348  60.963  103.551 1.00 29.66 ? 56  TYR H CD2 1 
ATOM   445  C CE1 . TYR A 1 61  ? 58.971  61.136  102.131 1.00 31.85 ? 56  TYR H CE1 1 
ATOM   446  C CE2 . TYR A 1 61  ? 60.201  61.402  104.195 1.00 29.45 ? 56  TYR H CE2 1 
ATOM   447  C CZ  . TYR A 1 61  ? 59.018  61.490  103.479 1.00 31.30 ? 56  TYR H CZ  1 
ATOM   448  O OH  . TYR A 1 61  ? 57.876  61.921  104.100 1.00 33.13 ? 56  TYR H OH  1 
ATOM   449  N N   . SER A 1 62  ? 63.008  63.399  101.849 1.00 25.92 ? 57  SER H N   1 
ATOM   450  C CA  . SER A 1 62  ? 63.309  64.418  102.821 1.00 28.03 ? 57  SER H CA  1 
ATOM   451  C C   . SER A 1 62  ? 62.043  64.966  103.455 1.00 30.50 ? 57  SER H C   1 
ATOM   452  O O   . SER A 1 62  ? 60.944  64.826  102.915 1.00 31.17 ? 57  SER H O   1 
ATOM   453  C CB  . SER A 1 62  ? 64.112  65.547  102.190 1.00 26.85 ? 57  SER H CB  1 
ATOM   454  O OG  . SER A 1 62  ? 63.301  66.268  101.280 1.00 25.56 ? 57  SER H OG  1 
ATOM   455  N N   . ASN A 1 63  ? 62.227  65.605  104.605 1.00 30.82 ? 58  ASN H N   1 
ATOM   456  C CA  . ASN A 1 63  ? 61.118  66.067  105.419 1.00 30.09 ? 58  ASN H CA  1 
ATOM   457  C C   . ASN A 1 63  ? 61.564  67.312  106.170 1.00 28.80 ? 58  ASN H C   1 
ATOM   458  O O   . ASN A 1 63  ? 62.581  67.288  106.877 1.00 26.16 ? 58  ASN H O   1 
ATOM   459  C CB  . ASN A 1 63  ? 60.707  64.928  106.368 1.00 33.00 ? 58  ASN H CB  1 
ATOM   460  C CG  . ASN A 1 63  ? 59.383  65.174  107.064 1.00 34.25 ? 58  ASN H CG  1 
ATOM   461  O OD1 . ASN A 1 63  ? 58.531  65.923  106.582 1.00 35.61 ? 58  ASN H OD1 1 
ATOM   462  N ND2 . ASN A 1 63  ? 59.200  64.527  108.211 1.00 33.73 ? 58  ASN H ND2 1 
ATOM   463  N N   . TYR A 1 64  ? 60.820  68.400  105.990 1.00 26.75 ? 59  TYR H N   1 
ATOM   464  C CA  . TYR A 1 64  ? 61.215  69.694  106.496 1.00 26.68 ? 59  TYR H CA  1 
ATOM   465  C C   . TYR A 1 64  ? 60.354  70.286  107.616 1.00 28.14 ? 59  TYR H C   1 
ATOM   466  O O   . TYR A 1 64  ? 59.142  70.069  107.691 1.00 27.36 ? 59  TYR H O   1 
ATOM   467  C CB  . TYR A 1 64  ? 61.243  70.702  105.355 1.00 26.52 ? 59  TYR H CB  1 
ATOM   468  C CG  . TYR A 1 64  ? 62.278  70.400  104.301 1.00 27.02 ? 59  TYR H CG  1 
ATOM   469  C CD1 . TYR A 1 64  ? 61.999  69.534  103.227 1.00 26.26 ? 59  TYR H CD1 1 
ATOM   470  C CD2 . TYR A 1 64  ? 63.543  70.981  104.369 1.00 26.24 ? 59  TYR H CD2 1 
ATOM   471  C CE1 . TYR A 1 64  ? 62.960  69.266  102.255 1.00 25.81 ? 59  TYR H CE1 1 
ATOM   472  C CE2 . TYR A 1 64  ? 64.509  70.725  103.396 1.00 26.76 ? 59  TYR H CE2 1 
ATOM   473  C CZ  . TYR A 1 64  ? 64.214  69.869  102.343 1.00 26.36 ? 59  TYR H CZ  1 
ATOM   474  O OH  . TYR A 1 64  ? 65.185  69.600  101.405 1.00 25.65 ? 59  TYR H OH  1 
ATOM   475  N N   . ASN A 1 65  ? 61.030  71.054  108.474 1.00 27.21 ? 60  ASN H N   1 
ATOM   476  C CA  . ASN A 1 65  ? 60.406  72.082  109.273 1.00 26.64 ? 60  ASN H CA  1 
ATOM   477  C C   . ASN A 1 65  ? 59.760  73.094  108.332 1.00 28.45 ? 60  ASN H C   1 
ATOM   478  O O   . ASN A 1 65  ? 60.444  73.844  107.629 1.00 28.44 ? 60  ASN H O   1 
ATOM   479  C CB  . ASN A 1 65  ? 61.455  72.771  110.163 1.00 24.98 ? 60  ASN H CB  1 
ATOM   480  C CG  . ASN A 1 65  ? 60.835  73.689  111.223 1.00 23.15 ? 60  ASN H CG  1 
ATOM   481  O OD1 . ASN A 1 65  ? 59.740  74.206  111.042 1.00 20.82 ? 60  ASN H OD1 1 
ATOM   482  N ND2 . ASN A 1 65  ? 61.550  73.893  112.332 1.00 21.29 ? 60  ASN H ND2 1 
ATOM   483  N N   . GLN A 1 66  ? 58.436  73.132  108.344 1.00 29.57 ? 61  GLN H N   1 
ATOM   484  C CA  . GLN A 1 66  ? 57.666  74.046  107.508 1.00 30.51 ? 61  GLN H CA  1 
ATOM   485  C C   . GLN A 1 66  ? 58.223  75.468  107.463 1.00 29.04 ? 61  GLN H C   1 
ATOM   486  O O   . GLN A 1 66  ? 58.147  76.122  106.441 1.00 31.25 ? 61  GLN H O   1 
ATOM   487  C CB  . GLN A 1 66  ? 56.195  74.055  107.964 1.00 33.36 ? 61  GLN H CB  1 
ATOM   488  C CG  . GLN A 1 66  ? 55.210  74.702  106.992 1.00 35.94 ? 61  GLN H CG  1 
ATOM   489  C CD  . GLN A 1 66  ? 55.177  74.088  105.586 1.00 39.07 ? 61  GLN H CD  1 
ATOM   490  O OE1 . GLN A 1 66  ? 54.917  74.804  104.615 1.00 43.11 ? 61  GLN H OE1 1 
ATOM   491  N NE2 . GLN A 1 66  ? 55.419  72.772  105.466 1.00 40.21 ? 61  GLN H NE2 1 
ATOM   492  N N   . LYS A 1 67  ? 58.797  75.946  108.558 1.00 29.01 ? 62  LYS H N   1 
ATOM   493  C CA  . LYS A 1 67  ? 59.430  77.270  108.601 1.00 27.94 ? 62  LYS H CA  1 
ATOM   494  C C   . LYS A 1 67  ? 60.573  77.456  107.575 1.00 27.03 ? 62  LYS H C   1 
ATOM   495  O O   . LYS A 1 67  ? 60.821  78.560  107.116 1.00 27.53 ? 62  LYS H O   1 
ATOM   496  C CB  . LYS A 1 67  ? 59.974  77.539  110.011 1.00 29.13 ? 62  LYS H CB  1 
ATOM   497  C CG  . LYS A 1 67  ? 60.580  78.927  110.154 1.00 33.10 ? 62  LYS H CG  1 
ATOM   498  C CD  . LYS A 1 67  ? 61.276  79.237  111.487 1.00 36.35 ? 62  LYS H CD  1 
ATOM   499  C CE  . LYS A 1 67  ? 62.436  80.216  111.246 1.00 37.48 ? 62  LYS H CE  1 
ATOM   500  N NZ  . LYS A 1 67  ? 62.802  81.072  112.400 1.00 39.04 ? 62  LYS H NZ  1 
ATOM   501  N N   . PHE A 1 68  ? 61.277  76.381  107.258 1.00 26.08 ? 63  PHE H N   1 
ATOM   502  C CA  . PHE A 1 68  ? 62.422  76.408  106.325 1.00 27.06 ? 63  PHE H CA  1 
ATOM   503  C C   . PHE A 1 68  ? 62.164  75.810  104.926 1.00 28.31 ? 63  PHE H C   1 
ATOM   504  O O   . PHE A 1 68  ? 63.053  75.873  104.077 1.00 26.28 ? 63  PHE H O   1 
ATOM   505  C CB  . PHE A 1 68  ? 63.601  75.667  106.954 1.00 24.69 ? 63  PHE H CB  1 
ATOM   506  C CG  . PHE A 1 68  ? 64.138  76.326  108.184 1.00 23.46 ? 63  PHE H CG  1 
ATOM   507  C CD1 . PHE A 1 68  ? 65.078  77.349  108.087 1.00 22.73 ? 63  PHE H CD1 1 
ATOM   508  C CD2 . PHE A 1 68  ? 63.708  75.926  109.448 1.00 22.02 ? 63  PHE H CD2 1 
ATOM   509  C CE1 . PHE A 1 68  ? 65.585  77.955  109.235 1.00 22.07 ? 63  PHE H CE1 1 
ATOM   510  C CE2 . PHE A 1 68  ? 64.214  76.523  110.593 1.00 21.47 ? 63  PHE H CE2 1 
ATOM   511  C CZ  . PHE A 1 68  ? 65.149  77.540  110.487 1.00 21.57 ? 63  PHE H CZ  1 
ATOM   512  N N   . LYS A 1 69  ? 60.983  75.218  104.711 1.00 30.53 ? 64  LYS H N   1 
ATOM   513  C CA  . LYS A 1 69  ? 60.598  74.615  103.410 1.00 33.07 ? 64  LYS H CA  1 
ATOM   514  C C   . LYS A 1 69  ? 60.768  75.660  102.293 1.00 31.10 ? 64  LYS H C   1 
ATOM   515  O O   . LYS A 1 69  ? 60.286  76.779  102.411 1.00 28.95 ? 64  LYS H O   1 
ATOM   516  C CB  . LYS A 1 69  ? 59.147  74.065  103.454 1.00 36.00 ? 64  LYS H CB  1 
ATOM   517  C CG  . LYS A 1 69  ? 58.914  72.804  102.630 1.00 38.47 ? 64  LYS H CG  1 
ATOM   518  C CD  . LYS A 1 69  ? 57.707  71.988  103.096 1.00 40.42 ? 64  LYS H CD  1 
ATOM   519  C CE  . LYS A 1 69  ? 57.694  70.572  102.519 1.00 42.13 ? 64  LYS H CE  1 
ATOM   520  N NZ  . LYS A 1 69  ? 58.300  69.541  103.428 1.00 44.96 ? 64  LYS H NZ  1 
ATOM   521  N N   . GLY A 1 70  ? 61.519  75.307  101.253 1.00 31.76 ? 65  GLY H N   1 
ATOM   522  C CA  . GLY A 1 70  ? 61.841  76.248  100.181 1.00 33.49 ? 65  GLY H CA  1 
ATOM   523  C C   . GLY A 1 70  ? 63.146  77.005  100.391 1.00 35.42 ? 65  GLY H C   1 
ATOM   524  O O   . GLY A 1 70  ? 63.963  77.067  99.463  1.00 35.98 ? 65  GLY H O   1 
ATOM   525  N N   . LYS A 1 71  ? 63.349  77.583  101.588 1.00 32.56 ? 66  LYS H N   1 
ATOM   526  C CA  . LYS A 1 71  ? 64.638  78.217  101.939 1.00 30.27 ? 66  LYS H CA  1 
ATOM   527  C C   . LYS A 1 71  ? 65.822  77.233  101.964 1.00 28.56 ? 66  LYS H C   1 
ATOM   528  O O   . LYS A 1 71  ? 66.886  77.527  101.404 1.00 27.45 ? 66  LYS H O   1 
ATOM   529  C CB  . LYS A 1 71  ? 64.554  78.944  103.280 1.00 30.97 ? 66  LYS H CB  1 
ATOM   530  C CG  . LYS A 1 71  ? 65.911  79.255  103.906 1.00 31.38 ? 66  LYS H CG  1 
ATOM   531  C CD  . LYS A 1 71  ? 65.996  80.667  104.415 1.00 32.10 ? 66  LYS H CD  1 
ATOM   532  C CE  . LYS A 1 71  ? 66.244  81.621  103.267 1.00 32.30 ? 66  LYS H CE  1 
ATOM   533  N NZ  . LYS A 1 71  ? 66.098  83.058  103.597 1.00 30.83 ? 66  LYS H NZ  1 
ATOM   534  N N   . ALA A 1 72  ? 65.640  76.098  102.639 1.00 25.74 ? 67  ALA H N   1 
ATOM   535  C CA  . ALA A 1 72  ? 66.683  75.084  102.765 1.00 24.33 ? 67  ALA H CA  1 
ATOM   536  C C   . ALA A 1 72  ? 66.382  73.916  101.876 1.00 22.64 ? 67  ALA H C   1 
ATOM   537  O O   . ALA A 1 72  ? 65.251  73.476  101.813 1.00 22.23 ? 67  ALA H O   1 
ATOM   538  C CB  . ALA A 1 72  ? 66.805  74.596  104.201 1.00 25.05 ? 67  ALA H CB  1 
ATOM   539  N N   . THR A 1 73  ? 67.402  73.383  101.216 1.00 21.44 ? 68  THR H N   1 
ATOM   540  C CA  . THR A 1 73  ? 67.228  72.218  100.390 1.00 21.09 ? 68  THR H CA  1 
ATOM   541  C C   . THR A 1 73  ? 68.277  71.215  100.762 1.00 20.17 ? 68  THR H C   1 
ATOM   542  O O   . THR A 1 73  ? 69.458  71.524  100.717 1.00 20.26 ? 68  THR H O   1 
ATOM   543  C CB  . THR A 1 73  ? 67.361  72.569  98.892  1.00 22.32 ? 68  THR H CB  1 
ATOM   544  O OG1 . THR A 1 73  ? 66.464  73.639  98.559  1.00 21.74 ? 68  THR H OG1 1 
ATOM   545  C CG2 . THR A 1 73  ? 67.051  71.375  98.043  1.00 22.25 ? 68  THR H CG2 1 
ATOM   546  N N   . LEU A 1 74  ? 67.849  70.003  101.108 1.00 20.42 ? 69  LEU H N   1 
ATOM   547  C CA  . LEU A 1 74  ? 68.774  68.943  101.487 1.00 21.04 ? 69  LEU H CA  1 
ATOM   548  C C   . LEU A 1 74  ? 68.970  67.990  100.348 1.00 22.24 ? 69  LEU H C   1 
ATOM   549  O O   . LEU A 1 74  ? 67.995  67.531  99.752  1.00 23.45 ? 69  LEU H O   1 
ATOM   550  C CB  . LEU A 1 74  ? 68.269  68.155  102.695 1.00 21.35 ? 69  LEU H CB  1 
ATOM   551  C CG  . LEU A 1 74  ? 67.918  68.937  103.959 1.00 21.96 ? 69  LEU H CG  1 
ATOM   552  C CD1 . LEU A 1 74  ? 67.585  67.990  105.108 1.00 21.72 ? 69  LEU H CD1 1 
ATOM   553  C CD2 . LEU A 1 74  ? 69.033  69.900  104.349 1.00 22.11 ? 69  LEU H CD2 1 
ATOM   554  N N   . THR A 1 75  ? 70.237  67.694  100.071 1.00 22.88 ? 70  THR H N   1 
ATOM   555  C CA  . THR A 1 75  ? 70.649  66.707  99.072  1.00 24.09 ? 70  THR H CA  1 
ATOM   556  C C   . THR A 1 75  ? 71.803  65.914  99.650  1.00 25.70 ? 70  THR H C   1 
ATOM   557  O O   . THR A 1 75  ? 72.480  66.390  100.579 1.00 24.94 ? 70  THR H O   1 
ATOM   558  C CB  . THR A 1 75  ? 71.119  67.372  97.753  1.00 23.45 ? 70  THR H CB  1 
ATOM   559  O OG1 . THR A 1 75  ? 72.171  68.318  98.000  1.00 22.36 ? 70  THR H OG1 1 
ATOM   560  C CG2 . THR A 1 75  ? 69.940  68.110  97.071  1.00 23.73 ? 70  THR H CG2 1 
ATOM   561  N N   . VAL A 1 76  ? 72.021  64.719  99.099  1.00 26.95 ? 71  VAL H N   1 
ATOM   562  C CA  . VAL A 1 76  ? 73.241  63.938  99.362  1.00 28.69 ? 71  VAL H CA  1 
ATOM   563  C C   . VAL A 1 76  ? 74.067  63.611  98.089  1.00 31.04 ? 71  VAL H C   1 
ATOM   564  O O   . VAL A 1 76  ? 73.579  63.724  96.955  1.00 31.34 ? 71  VAL H O   1 
ATOM   565  C CB  . VAL A 1 76  ? 72.915  62.638  100.142 1.00 30.09 ? 71  VAL H CB  1 
ATOM   566  C CG1 . VAL A 1 76  ? 72.238  62.971  101.479 1.00 30.00 ? 71  VAL H CG1 1 
ATOM   567  C CG2 . VAL A 1 76  ? 72.051  61.684  99.324  1.00 31.12 ? 71  VAL H CG2 1 
ATOM   568  N N   . ASP A 1 77  ? 75.326  63.224  98.301  1.00 31.98 ? 72  ASP H N   1 
ATOM   569  C CA  . ASP A 1 77  ? 76.181  62.605  97.276  1.00 31.13 ? 72  ASP H CA  1 
ATOM   570  C C   . ASP A 1 77  ? 76.760  61.352  97.898  1.00 33.52 ? 72  ASP H C   1 
ATOM   571  O O   . ASP A 1 77  ? 77.640  61.440  98.767  1.00 35.07 ? 72  ASP H O   1 
ATOM   572  C CB  . ASP A 1 77  ? 77.311  63.553  96.830  1.00 31.78 ? 72  ASP H CB  1 
ATOM   573  C CG  . ASP A 1 77  ? 78.340  62.876  95.881  1.00 31.60 ? 72  ASP H CG  1 
ATOM   574  O OD1 . ASP A 1 77  ? 78.017  61.887  95.217  1.00 34.10 ? 72  ASP H OD1 1 
ATOM   575  O OD2 . ASP A 1 77  ? 79.483  63.330  95.803  1.00 32.06 ? 72  ASP H OD2 1 
ATOM   576  N N   . LYS A 1 78  ? 76.286  60.190  97.463  1.00 33.99 ? 73  LYS H N   1 
ATOM   577  C CA  . LYS A 1 78  ? 76.814  58.926  97.978  1.00 37.21 ? 73  LYS H CA  1 
ATOM   578  C C   . LYS A 1 78  ? 78.296  58.690  97.693  1.00 35.59 ? 73  LYS H C   1 
ATOM   579  O O   . LYS A 1 78  ? 79.028  58.283  98.590  1.00 35.30 ? 73  LYS H O   1 
ATOM   580  C CB  . LYS A 1 78  ? 75.994  57.756  97.460  1.00 38.53 ? 73  LYS H CB  1 
ATOM   581  C CG  . LYS A 1 78  ? 74.664  57.654  98.175  1.00 40.13 ? 73  LYS H CG  1 
ATOM   582  C CD  . LYS A 1 78  ? 73.572  57.089  97.294  1.00 41.76 ? 73  LYS H CD  1 
ATOM   583  C CE  . LYS A 1 78  ? 72.222  57.564  97.785  1.00 44.35 ? 73  LYS H CE  1 
ATOM   584  N NZ  . LYS A 1 78  ? 71.175  56.531  97.577  1.00 45.37 ? 73  LYS H NZ  1 
ATOM   585  N N   . SER A 1 79  ? 78.745  58.980  96.472  1.00 35.74 ? 74  SER H N   1 
ATOM   586  C CA  . SER A 1 79  ? 80.140  58.735  96.095  1.00 35.51 ? 74  SER H CA  1 
ATOM   587  C C   . SER A 1 79  ? 81.114  59.261  97.167  1.00 35.50 ? 74  SER H C   1 
ATOM   588  O O   . SER A 1 79  ? 82.092  58.603  97.493  1.00 35.33 ? 74  SER H O   1 
ATOM   589  C CB  . SER A 1 79  ? 80.459  59.357  94.732  1.00 35.14 ? 74  SER H CB  1 
ATOM   590  O OG  . SER A 1 79  ? 79.596  58.854  93.732  1.00 35.26 ? 74  SER H OG  1 
ATOM   591  N N   . SER A 1 80  ? 80.821  60.437  97.728  1.00 34.19 ? 75  SER H N   1 
ATOM   592  C CA  . SER A 1 80  ? 81.693  61.047  98.730  1.00 33.17 ? 75  SER H CA  1 
ATOM   593  C C   . SER A 1 80  ? 81.192  60.959  100.192 1.00 30.28 ? 75  SER H C   1 
ATOM   594  O O   . SER A 1 80  ? 81.836  61.513  101.087 1.00 28.46 ? 75  SER H O   1 
ATOM   595  C CB  . SER A 1 80  ? 81.969  62.502  98.337  1.00 33.08 ? 75  SER H CB  1 
ATOM   596  O OG  . SER A 1 80  ? 80.777  63.265  98.287  1.00 34.72 ? 75  SER H OG  1 
ATOM   597  N N   . SER A 1 81  ? 80.086  60.247  100.421 1.00 29.17 ? 76  SER H N   1 
ATOM   598  C CA  . SER A 1 81  ? 79.384  60.193  101.738 1.00 28.58 ? 76  SER H CA  1 
ATOM   599  C C   . SER A 1 81  ? 79.163  61.607  102.323 1.00 26.74 ? 76  SER H C   1 
ATOM   600  O O   . SER A 1 81  ? 79.466  61.861  103.503 1.00 26.40 ? 76  SER H O   1 
ATOM   601  C CB  . SER A 1 81  ? 80.172  59.346  102.752 1.00 29.22 ? 76  SER H CB  1 
ATOM   602  O OG  . SER A 1 81  ? 79.958  57.969  102.576 1.00 31.32 ? 76  SER H OG  1 
ATOM   603  N N   . THR A 1 82  ? 78.681  62.513  101.487 1.00 22.95 ? 77  THR H N   1 
ATOM   604  C CA  . THR A 1 82  ? 78.512  63.902  101.866 1.00 22.92 ? 77  THR H CA  1 
ATOM   605  C C   . THR A 1 82  ? 77.043  64.281  101.781 1.00 21.72 ? 77  THR H C   1 
ATOM   606  O O   . THR A 1 82  ? 76.322  63.852  100.855 1.00 21.02 ? 77  THR H O   1 
ATOM   607  C CB  . THR A 1 82  ? 79.358  64.838  100.979 1.00 22.87 ? 77  THR H CB  1 
ATOM   608  O OG1 . THR A 1 82  ? 80.717  64.392  100.983 1.00 23.95 ? 77  THR H OG1 1 
ATOM   609  C CG2 . THR A 1 82  ? 79.329  66.242  101.500 1.00 23.12 ? 77  THR H CG2 1 
ATOM   610  N N   . ALA A 1 83  ? 76.613  65.061  102.775 1.00 19.79 ? 78  ALA H N   1 
ATOM   611  C CA  . ALA A 1 83  ? 75.301  65.688  102.784 1.00 19.49 ? 78  ALA H CA  1 
ATOM   612  C C   . ALA A 1 83  ? 75.503  67.163  102.578 1.00 18.49 ? 78  ALA H C   1 
ATOM   613  O O   . ALA A 1 83  ? 76.513  67.714  102.994 1.00 18.59 ? 78  ALA H O   1 
ATOM   614  C CB  . ALA A 1 83  ? 74.586  65.432  104.104 1.00 19.98 ? 78  ALA H CB  1 
ATOM   615  N N   . TYR A 1 84  ? 74.524  67.786  101.933 1.00 18.78 ? 79  TYR H N   1 
ATOM   616  C CA  . TYR A 1 84  ? 74.540  69.192  101.617 1.00 19.23 ? 79  TYR H CA  1 
ATOM   617  C C   . TYR A 1 84  ? 73.289  69.883  102.061 1.00 19.33 ? 79  TYR H C   1 
ATOM   618  O O   . TYR A 1 84  ? 72.233  69.282  102.125 1.00 19.79 ? 79  TYR H O   1 
ATOM   619  C CB  . TYR A 1 84  ? 74.580  69.362  100.113 1.00 20.39 ? 79  TYR H CB  1 
ATOM   620  C CG  . TYR A 1 84  ? 75.810  68.813  99.491  1.00 21.09 ? 79  TYR H CG  1 
ATOM   621  C CD1 . TYR A 1 84  ? 76.962  69.578  99.455  1.00 22.22 ? 79  TYR H CD1 1 
ATOM   622  C CD2 . TYR A 1 84  ? 75.838  67.541  98.928  1.00 21.99 ? 79  TYR H CD2 1 
ATOM   623  C CE1 . TYR A 1 84  ? 78.116  69.111  98.867  1.00 21.40 ? 79  TYR H CE1 1 
ATOM   624  C CE2 . TYR A 1 84  ? 77.005  67.058  98.353  1.00 22.96 ? 79  TYR H CE2 1 
ATOM   625  C CZ  . TYR A 1 84  ? 78.130  67.870  98.337  1.00 21.82 ? 79  TYR H CZ  1 
ATOM   626  O OH  . TYR A 1 84  ? 79.299  67.464  97.794  1.00 24.97 ? 79  TYR H OH  1 
ATOM   627  N N   . MET A 1 85  ? 73.418  71.171  102.329 1.00 19.55 ? 80  MET H N   1 
ATOM   628  C CA  . MET A 1 85  ? 72.289  72.009  102.550 1.00 19.92 ? 80  MET H CA  1 
ATOM   629  C C   . MET A 1 85  ? 72.506  73.276  101.775 1.00 20.08 ? 80  MET H C   1 
ATOM   630  O O   . MET A 1 85  ? 73.500  73.976  101.992 1.00 21.10 ? 80  MET H O   1 
ATOM   631  C CB  . MET A 1 85  ? 72.093  72.356  104.023 1.00 19.98 ? 80  MET H CB  1 
ATOM   632  C CG  . MET A 1 85  ? 70.935  73.333  104.192 1.00 19.46 ? 80  MET H CG  1 
ATOM   633  S SD  . MET A 1 85  ? 70.317  73.452  105.876 1.00 20.06 ? 80  MET H SD  1 
ATOM   634  C CE  . MET A 1 85  ? 71.700  74.359  106.582 1.00 19.86 ? 80  MET H CE  1 
ATOM   635  N N   . HIS A 1 86  ? 71.542  73.574  100.904 1.00 20.24 ? 81  HIS H N   1 
ATOM   636  C CA  . HIS A 1 86  ? 71.535  74.782  100.107 1.00 20.74 ? 81  HIS H CA  1 
ATOM   637  C C   . HIS A 1 86  ? 70.572  75.755  100.747 1.00 19.64 ? 81  HIS H C   1 
ATOM   638  O O   . HIS A 1 86  ? 69.455  75.381  101.032 1.00 19.57 ? 81  HIS H O   1 
ATOM   639  C CB  . HIS A 1 86  ? 71.079  74.462  98.674  1.00 22.53 ? 81  HIS H CB  1 
ATOM   640  C CG  . HIS A 1 86  ? 71.136  75.633  97.744  1.00 23.67 ? 81  HIS H CG  1 
ATOM   641  N ND1 . HIS A 1 86  ? 70.126  76.570  97.655  1.00 25.08 ? 81  HIS H ND1 1 
ATOM   642  C CD2 . HIS A 1 86  ? 72.082  76.016  96.855  1.00 24.79 ? 81  HIS H CD2 1 
ATOM   643  C CE1 . HIS A 1 86  ? 70.446  77.475  96.748  1.00 25.87 ? 81  HIS H CE1 1 
ATOM   644  N NE2 . HIS A 1 86  ? 71.626  77.160  96.250  1.00 25.29 ? 81  HIS H NE2 1 
ATOM   645  N N   . LEU A 1 87  ? 71.015  76.993  100.956 1.00 19.96 ? 82  LEU H N   1 
ATOM   646  C CA  . LEU A 1 87  ? 70.196  78.072  101.475 1.00 20.95 ? 82  LEU H CA  1 
ATOM   647  C C   . LEU A 1 87  ? 70.135  79.157  100.412 1.00 23.49 ? 82  LEU H C   1 
ATOM   648  O O   . LEU A 1 87  ? 71.167  79.508  99.821  1.00 25.82 ? 82  LEU H O   1 
ATOM   649  C CB  . LEU A 1 87  ? 70.803  78.614  102.772 1.00 20.86 ? 82  LEU H CB  1 
ATOM   650  C CG  . LEU A 1 87  ? 70.862  77.673  103.985 1.00 21.10 ? 82  LEU H CG  1 
ATOM   651  C CD1 . LEU A 1 87  ? 71.791  78.198  105.078 1.00 21.23 ? 82  LEU H CD1 1 
ATOM   652  C CD2 . LEU A 1 87  ? 69.481  77.470  104.575 1.00 21.15 ? 82  LEU H CD2 1 
ATOM   653  N N   . ASN A 1 88  A 68.933  79.680  100.148 1.00 24.64 ? 82  ASN H N   1 
ATOM   654  C CA  . ASN A 1 88  A 68.725  80.642  99.053  1.00 24.28 ? 82  ASN H CA  1 
ATOM   655  C C   . ASN A 1 88  A 68.088  81.923  99.556  1.00 28.20 ? 82  ASN H C   1 
ATOM   656  O O   . ASN A 1 88  A 67.535  81.951  100.656 1.00 29.75 ? 82  ASN H O   1 
ATOM   657  C CB  . ASN A 1 88  A 67.887  80.021  97.949  1.00 23.56 ? 82  ASN H CB  1 
ATOM   658  C CG  . ASN A 1 88  A 66.420  79.876  98.333  1.00 22.90 ? 82  ASN H CG  1 
ATOM   659  O OD1 . ASN A 1 88  A 65.701  80.869  98.452  1.00 24.26 ? 82  ASN H OD1 1 
ATOM   660  N ND2 . ASN A 1 88  A 65.975  78.654  98.522  1.00 21.33 ? 82  ASN H ND2 1 
ATOM   661  N N   . SER A 1 89  B 68.172  82.978  98.750  1.00 29.33 ? 82  SER H N   1 
ATOM   662  C CA  . SER A 1 89  B 67.601  84.299  99.087  1.00 32.83 ? 82  SER H CA  1 
ATOM   663  C C   . SER A 1 89  B 67.972  84.725  100.509 1.00 34.17 ? 82  SER H C   1 
ATOM   664  O O   . SER A 1 89  B 67.102  85.030  101.326 1.00 34.49 ? 82  SER H O   1 
ATOM   665  C CB  . SER A 1 89  B 66.060  84.333  98.911  1.00 33.86 ? 82  SER H CB  1 
ATOM   666  O OG  . SER A 1 89  B 65.590  83.329  98.023  1.00 37.38 ? 82  SER H OG  1 
ATOM   667  N N   . LEU A 1 90  C 69.271  84.752  100.797 1.00 33.71 ? 82  LEU H N   1 
ATOM   668  C CA  . LEU A 1 90  C 69.729  84.958  102.168 1.00 33.36 ? 82  LEU H CA  1 
ATOM   669  C C   . LEU A 1 90  C 69.420  86.355  102.687 1.00 34.56 ? 82  LEU H C   1 
ATOM   670  O O   . LEU A 1 90  C 69.603  87.341  101.961 1.00 34.07 ? 82  LEU H O   1 
ATOM   671  C CB  . LEU A 1 90  C 71.221  84.684  102.279 1.00 33.61 ? 82  LEU H CB  1 
ATOM   672  C CG  . LEU A 1 90  C 71.601  83.235  101.994 1.00 33.59 ? 82  LEU H CG  1 
ATOM   673  C CD1 . LEU A 1 90  C 73.045  83.134  101.556 1.00 34.17 ? 82  LEU H CD1 1 
ATOM   674  C CD2 . LEU A 1 90  C 71.350  82.346  103.204 1.00 34.33 ? 82  LEU H CD2 1 
ATOM   675  N N   . THR A 1 91  ? 68.914  86.417  103.923 1.00 33.84 ? 83  THR H N   1 
ATOM   676  C CA  . THR A 1 91  ? 68.738  87.674  104.672 1.00 34.90 ? 83  THR H CA  1 
ATOM   677  C C   . THR A 1 91  ? 69.630  87.628  105.895 1.00 33.43 ? 83  THR H C   1 
ATOM   678  O O   . THR A 1 91  ? 70.269  86.618  106.165 1.00 32.23 ? 83  THR H O   1 
ATOM   679  C CB  . THR A 1 91  ? 67.279  87.898  105.126 1.00 35.51 ? 83  THR H CB  1 
ATOM   680  O OG1 . THR A 1 91  ? 66.873  86.848  106.012 1.00 36.02 ? 83  THR H OG1 1 
ATOM   681  C CG2 . THR A 1 91  ? 66.341  87.937  103.918 1.00 35.88 ? 83  THR H CG2 1 
ATOM   682  N N   . SER A 1 92  ? 69.687  88.716  106.643 1.00 33.91 ? 84  SER H N   1 
ATOM   683  C CA  . SER A 1 92  ? 70.542  88.740  107.820 1.00 36.11 ? 84  SER H CA  1 
ATOM   684  C C   . SER A 1 92  ? 69.999  87.815  108.918 1.00 35.07 ? 84  SER H C   1 
ATOM   685  O O   . SER A 1 92  ? 70.766  87.285  109.686 1.00 36.26 ? 84  SER H O   1 
ATOM   686  C CB  . SER A 1 92  ? 70.789  90.167  108.307 1.00 36.43 ? 84  SER H CB  1 
ATOM   687  O OG  . SER A 1 92  ? 69.619  90.727  108.848 1.00 39.42 ? 84  SER H OG  1 
ATOM   688  N N   . GLU A 1 93  ? 68.694  87.563  108.918 1.00 36.23 ? 85  GLU H N   1 
ATOM   689  C CA  . GLU A 1 93  ? 68.077  86.464  109.683 1.00 36.80 ? 85  GLU H CA  1 
ATOM   690  C C   . GLU A 1 93  ? 68.643  85.058  109.439 1.00 32.95 ? 85  GLU H C   1 
ATOM   691  O O   . GLU A 1 93  ? 68.444  84.166  110.270 1.00 31.79 ? 85  GLU H O   1 
ATOM   692  C CB  . GLU A 1 93  ? 66.575  86.416  109.403 1.00 41.32 ? 85  GLU H CB  1 
ATOM   693  C CG  . GLU A 1 93  ? 65.767  87.417  110.196 1.00 46.61 ? 85  GLU H CG  1 
ATOM   694  C CD  . GLU A 1 93  ? 64.362  87.553  109.667 1.00 53.01 ? 85  GLU H CD  1 
ATOM   695  O OE1 . GLU A 1 93  ? 64.159  88.414  108.780 1.00 60.02 ? 85  GLU H OE1 1 
ATOM   696  O OE2 . GLU A 1 93  ? 63.470  86.802  110.132 1.00 56.37 ? 85  GLU H OE2 1 
ATOM   697  N N   . ASP A 1 94  ? 69.291  84.848  108.296 1.00 29.31 ? 86  ASP H N   1 
ATOM   698  C CA  . ASP A 1 94  ? 69.977  83.590  108.002 1.00 26.21 ? 86  ASP H CA  1 
ATOM   699  C C   . ASP A 1 94  ? 71.412  83.520  108.558 1.00 24.63 ? 86  ASP H C   1 
ATOM   700  O O   . ASP A 1 94  ? 72.053  82.472  108.464 1.00 24.24 ? 86  ASP H O   1 
ATOM   701  C CB  . ASP A 1 94  ? 69.988  83.348  106.497 1.00 27.20 ? 86  ASP H CB  1 
ATOM   702  C CG  . ASP A 1 94  ? 68.589  83.237  105.909 1.00 29.40 ? 86  ASP H CG  1 
ATOM   703  O OD1 . ASP A 1 94  ? 67.773  82.436  106.401 1.00 29.62 ? 86  ASP H OD1 1 
ATOM   704  O OD2 . ASP A 1 94  ? 68.292  83.940  104.927 1.00 31.00 ? 86  ASP H OD2 1 
ATOM   705  N N   . SER A 1 95  ? 71.918  84.619  109.121 1.00 22.36 ? 87  SER H N   1 
ATOM   706  C CA  . SER A 1 95  ? 73.227  84.610  109.740 1.00 22.65 ? 87  SER H CA  1 
ATOM   707  C C   . SER A 1 95  ? 73.140  83.745  110.993 1.00 21.73 ? 87  SER H C   1 
ATOM   708  O O   . SER A 1 95  ? 72.393  84.055  111.920 1.00 21.76 ? 87  SER H O   1 
ATOM   709  C CB  . SER A 1 95  ? 73.701  86.007  110.131 1.00 22.46 ? 87  SER H CB  1 
ATOM   710  O OG  . SER A 1 95  ? 73.970  86.780  108.984 1.00 22.88 ? 87  SER H OG  1 
ATOM   711  N N   . ALA A 1 96  ? 73.892  82.663  110.999 1.00 19.02 ? 88  ALA H N   1 
ATOM   712  C CA  . ALA A 1 96  ? 73.767  81.674  112.041 1.00 19.16 ? 88  ALA H CA  1 
ATOM   713  C C   . ALA A 1 96  ? 74.882  80.659  111.905 1.00 18.62 ? 88  ALA H C   1 
ATOM   714  O O   . ALA A 1 96  ? 75.647  80.691  110.949 1.00 18.00 ? 88  ALA H O   1 
ATOM   715  C CB  . ALA A 1 96  ? 72.422  80.947  111.918 1.00 19.54 ? 88  ALA H CB  1 
ATOM   716  N N   . VAL A 1 97  ? 74.927  79.747  112.871 1.00 18.09 ? 89  VAL H N   1 
ATOM   717  C CA  . VAL A 1 97  ? 75.731  78.530  112.791 1.00 17.70 ? 89  VAL H CA  1 
ATOM   718  C C   . VAL A 1 97  ? 74.794  77.412  112.410 1.00 16.81 ? 89  VAL H C   1 
ATOM   719  O O   . VAL A 1 97  ? 73.723  77.271  113.017 1.00 18.45 ? 89  VAL H O   1 
ATOM   720  C CB  . VAL A 1 97  ? 76.370  78.174  114.151 1.00 17.48 ? 89  VAL H CB  1 
ATOM   721  C CG1 . VAL A 1 97  ? 77.267  76.954  114.011 1.00 18.24 ? 89  VAL H CG1 1 
ATOM   722  C CG2 . VAL A 1 97  ? 77.188  79.335  114.678 1.00 17.48 ? 89  VAL H CG2 1 
ATOM   723  N N   . TYR A 1 98  ? 75.204  76.600  111.448 1.00 16.07 ? 90  TYR H N   1 
ATOM   724  C CA  . TYR A 1 98  ? 74.395  75.500  110.957 1.00 15.78 ? 90  TYR H CA  1 
ATOM   725  C C   . TYR A 1 98  ? 75.139  74.224  111.224 1.00 15.86 ? 90  TYR H C   1 
ATOM   726  O O   . TYR A 1 98  ? 76.331  74.143  110.925 1.00 15.40 ? 90  TYR H O   1 
ATOM   727  C CB  . TYR A 1 98  ? 74.124  75.659  109.444 1.00 16.00 ? 90  TYR H CB  1 
ATOM   728  C CG  . TYR A 1 98  ? 73.235  76.848  109.139 1.00 16.20 ? 90  TYR H CG  1 
ATOM   729  C CD1 . TYR A 1 98  ? 73.779  78.099  108.906 1.00 15.97 ? 90  TYR H CD1 1 
ATOM   730  C CD2 . TYR A 1 98  ? 71.836  76.720  109.097 1.00 15.91 ? 90  TYR H CD2 1 
ATOM   731  C CE1 . TYR A 1 98  ? 72.964  79.198  108.644 1.00 16.05 ? 90  TYR H CE1 1 
ATOM   732  C CE2 . TYR A 1 98  ? 71.026  77.810  108.834 1.00 15.47 ? 90  TYR H CE2 1 
ATOM   733  C CZ  . TYR A 1 98  ? 71.595  79.045  108.616 1.00 15.47 ? 90  TYR H CZ  1 
ATOM   734  O OH  . TYR A 1 98  ? 70.822  80.146  108.351 1.00 15.79 ? 90  TYR H OH  1 
ATOM   735  N N   . TYR A 1 99  ? 74.434  73.233  111.766 1.00 15.80 ? 91  TYR H N   1 
ATOM   736  C CA  . TYR A 1 99  ? 75.007  71.951  112.109 1.00 16.12 ? 91  TYR H CA  1 
ATOM   737  C C   . TYR A 1 99  ? 74.350  70.860  111.319 1.00 17.31 ? 91  TYR H C   1 
ATOM   738  O O   . TYR A 1 99  ? 73.154  70.899  111.041 1.00 15.20 ? 91  TYR H O   1 
ATOM   739  C CB  . TYR A 1 99  ? 74.766  71.591  113.586 1.00 16.60 ? 91  TYR H CB  1 
ATOM   740  C CG  . TYR A 1 99  ? 75.447  72.492  114.560 1.00 16.57 ? 91  TYR H CG  1 
ATOM   741  C CD1 . TYR A 1 99  ? 76.785  72.313  114.885 1.00 16.92 ? 91  TYR H CD1 1 
ATOM   742  C CD2 . TYR A 1 99  ? 74.763  73.543  115.143 1.00 16.30 ? 91  TYR H CD2 1 
ATOM   743  C CE1 . TYR A 1 99  ? 77.421  73.166  115.788 1.00 16.89 ? 91  TYR H CE1 1 
ATOM   744  C CE2 . TYR A 1 99  ? 75.382  74.387  116.037 1.00 16.93 ? 91  TYR H CE2 1 
ATOM   745  C CZ  . TYR A 1 99  ? 76.710  74.200  116.360 1.00 16.89 ? 91  TYR H CZ  1 
ATOM   746  O OH  . TYR A 1 99  ? 77.294  75.066  117.257 1.00 17.61 ? 91  TYR H OH  1 
ATOM   747  N N   . CYS A 1 100 ? 75.136  69.829  111.067 1.00 19.30 ? 92  CYS H N   1 
ATOM   748  C CA  . CYS A 1 100 ? 74.660  68.629  110.443 1.00 22.98 ? 92  CYS H CA  1 
ATOM   749  C C   . CYS A 1 100 ? 74.836  67.550  111.509 1.00 21.87 ? 92  CYS H C   1 
ATOM   750  O O   . CYS A 1 100 ? 75.816  67.586  112.272 1.00 21.03 ? 92  CYS H O   1 
ATOM   751  C CB  . CYS A 1 100 ? 75.489  68.408  109.177 1.00 26.97 ? 92  CYS H CB  1 
ATOM   752  S SG  . CYS A 1 100 ? 75.496  66.782  108.413 1.00 33.84 ? 92  CYS H SG  1 
ATOM   753  N N   . THR A 1 101 ? 73.881  66.629  111.583 1.00 21.55 ? 93  THR H N   1 
ATOM   754  C CA  . THR A 1 101 ? 73.864  65.591  112.615 1.00 23.31 ? 93  THR H CA  1 
ATOM   755  C C   . THR A 1 101 ? 73.541  64.219  112.065 1.00 24.17 ? 93  THR H C   1 
ATOM   756  O O   . THR A 1 101 ? 72.801  64.058  111.097 1.00 23.00 ? 93  THR H O   1 
ATOM   757  C CB  . THR A 1 101 ? 72.831  65.838  113.762 1.00 24.11 ? 93  THR H CB  1 
ATOM   758  O OG1 . THR A 1 101 ? 71.576  65.249  113.421 1.00 23.46 ? 93  THR H OG1 1 
ATOM   759  C CG2 . THR A 1 101 ? 72.624  67.327  114.056 1.00 23.71 ? 93  THR H CG2 1 
ATOM   760  N N   . SER A 1 102 ? 74.090  63.243  112.762 1.00 26.56 ? 94  SER H N   1 
ATOM   761  C CA  . SER A 1 102 ? 73.927  61.845  112.474 1.00 30.53 ? 94  SER H CA  1 
ATOM   762  C C   . SER A 1 102 ? 72.767  61.269  113.285 1.00 34.06 ? 94  SER H C   1 
ATOM   763  O O   . SER A 1 102 ? 72.302  61.879  114.242 1.00 34.14 ? 94  SER H O   1 
ATOM   764  C CB  . SER A 1 102 ? 75.226  61.111  112.825 1.00 32.17 ? 94  SER H CB  1 
ATOM   765  O OG  . SER A 1 102 ? 75.722  61.443  114.135 1.00 34.10 ? 94  SER H OG  1 
ATOM   766  N N   . SER A 1 103 ? 72.304  60.088  112.894 1.00 40.22 ? 95  SER H N   1 
ATOM   767  C CA  . SER A 1 103 ? 71.346  59.332  113.703 1.00 41.21 ? 95  SER H CA  1 
ATOM   768  C C   . SER A 1 103 ? 71.978  58.973  115.063 1.00 40.12 ? 95  SER H C   1 
ATOM   769  O O   . SER A 1 103 ? 73.189  58.766  115.153 1.00 36.65 ? 95  SER H O   1 
ATOM   770  C CB  . SER A 1 103 ? 70.894  58.076  112.952 1.00 43.42 ? 95  SER H CB  1 
ATOM   771  O OG  . SER A 1 103 ? 70.032  57.278  113.754 1.00 48.46 ? 95  SER H OG  1 
ATOM   772  N N   . THR A 1 104 ? 71.151  58.923  116.113 1.00 40.46 ? 96  THR H N   1 
ATOM   773  C CA  . THR A 1 104 ? 71.601  58.543  117.461 1.00 41.91 ? 96  THR H CA  1 
ATOM   774  C C   . THR A 1 104 ? 72.266  57.152  117.477 1.00 44.60 ? 96  THR H C   1 
ATOM   775  O O   . THR A 1 104 ? 73.275  56.948  118.166 1.00 41.57 ? 96  THR H O   1 
ATOM   776  C CB  . THR A 1 104 ? 70.454  58.590  118.510 1.00 43.41 ? 96  THR H CB  1 
ATOM   777  O OG1 . THR A 1 104 ? 69.400  57.697  118.135 1.00 43.97 ? 96  THR H OG1 1 
ATOM   778  C CG2 . THR A 1 104 ? 69.883  60.020  118.664 1.00 42.62 ? 96  THR H CG2 1 
ATOM   779  N N   . SER A 1 105 ? 71.722  56.227  116.681 1.00 45.39 ? 97  SER H N   1 
ATOM   780  C CA  . SER A 1 105 ? 72.227  54.849  116.584 1.00 49.75 ? 97  SER H CA  1 
ATOM   781  C C   . SER A 1 105 ? 73.672  54.726  116.057 1.00 49.23 ? 97  SER H C   1 
ATOM   782  O O   . SER A 1 105 ? 74.397  53.787  116.438 1.00 43.44 ? 97  SER H O   1 
ATOM   783  C CB  . SER A 1 105 ? 71.285  54.003  115.721 1.00 54.05 ? 97  SER H CB  1 
ATOM   784  O OG  . SER A 1 105 ? 71.208  54.518  114.401 1.00 56.08 ? 97  SER H OG  1 
ATOM   785  N N   . VAL A 1 106 ? 74.094  55.673  115.208 1.00 48.11 ? 98  VAL H N   1 
ATOM   786  C CA  . VAL A 1 106 ? 75.527  55.795  114.847 1.00 48.51 ? 98  VAL H CA  1 
ATOM   787  C C   . VAL A 1 106 ? 76.317  56.687  115.823 1.00 47.56 ? 98  VAL H C   1 
ATOM   788  O O   . VAL A 1 106 ? 77.448  57.056  115.534 1.00 49.72 ? 98  VAL H O   1 
ATOM   789  C CB  . VAL A 1 106 ? 75.757  56.267  113.383 1.00 49.11 ? 98  VAL H CB  1 
ATOM   790  C CG1 . VAL A 1 106 ? 74.919  55.462  112.415 1.00 49.82 ? 98  VAL H CG1 1 
ATOM   791  C CG2 . VAL A 1 106 ? 75.469  57.747  113.181 1.00 48.36 ? 98  VAL H CG2 1 
ATOM   792  N N   . GLY A 1 107 ? 75.744  56.996  116.985 1.00 44.37 ? 99  GLY H N   1 
ATOM   793  C CA  . GLY A 1 107 ? 76.329  57.959  117.901 1.00 42.61 ? 99  GLY H CA  1 
ATOM   794  C C   . GLY A 1 107 ? 75.575  59.277  118.055 1.00 41.72 ? 99  GLY H C   1 
ATOM   795  O O   . GLY A 1 107 ? 75.630  59.908  119.101 1.00 43.15 ? 99  GLY H O   1 
ATOM   796  N N   . GLY A 1 108 ? 74.887  59.725  117.013 1.00 39.68 ? 101 GLY H N   1 
ATOM   797  C CA  . GLY A 1 108 ? 74.225  61.026  117.050 1.00 37.05 ? 101 GLY H CA  1 
ATOM   798  C C   . GLY A 1 108 ? 75.155  62.182  117.364 1.00 35.65 ? 101 GLY H C   1 
ATOM   799  O O   . GLY A 1 108 ? 74.741  63.143  118.006 1.00 34.41 ? 101 GLY H O   1 
ATOM   800  N N   . SER A 1 109 ? 76.416  62.089  116.936 1.00 34.04 ? 102 SER H N   1 
ATOM   801  C CA  . SER A 1 109 ? 77.301  63.252  116.984 1.00 33.62 ? 102 SER H CA  1 
ATOM   802  C C   . SER A 1 109 ? 76.857  64.246  115.910 1.00 29.47 ? 102 SER H C   1 
ATOM   803  O O   . SER A 1 109 ? 76.052  63.946  115.009 1.00 27.43 ? 102 SER H O   1 
ATOM   804  C CB  . SER A 1 109 ? 78.785  62.900  116.824 1.00 34.38 ? 102 SER H CB  1 
ATOM   805  O OG  . SER A 1 109 ? 79.059  62.320  115.550 1.00 35.16 ? 102 SER H OG  1 
ATOM   806  N N   . TRP A 1 110 ? 77.340  65.455  116.106 1.00 26.13 ? 103 TRP H N   1 
ATOM   807  C CA  . TRP A 1 110 ? 77.017  66.583  115.295 1.00 24.83 ? 103 TRP H CA  1 
ATOM   808  C C   . TRP A 1 110 ? 78.331  66.984  114.666 1.00 23.91 ? 103 TRP H C   1 
ATOM   809  O O   . TRP A 1 110 ? 79.398  66.767  115.242 1.00 23.07 ? 103 TRP H O   1 
ATOM   810  C CB  . TRP A 1 110 ? 76.497  67.726  116.166 1.00 23.94 ? 103 TRP H CB  1 
ATOM   811  C CG  . TRP A 1 110 ? 75.085  67.542  116.687 1.00 23.45 ? 103 TRP H CG  1 
ATOM   812  C CD1 . TRP A 1 110 ? 74.461  66.371  117.044 1.00 22.48 ? 103 TRP H CD1 1 
ATOM   813  C CD2 . TRP A 1 110 ? 74.128  68.581  116.912 1.00 22.29 ? 103 TRP H CD2 1 
ATOM   814  N NE1 . TRP A 1 110 ? 73.182  66.625  117.471 1.00 22.30 ? 103 TRP H NE1 1 
ATOM   815  C CE2 . TRP A 1 110 ? 72.949  67.969  117.399 1.00 21.48 ? 103 TRP H CE2 1 
ATOM   816  C CE3 . TRP A 1 110 ? 74.152  69.968  116.743 1.00 21.07 ? 103 TRP H CE3 1 
ATOM   817  C CZ2 . TRP A 1 110 ? 71.814  68.697  117.722 1.00 21.69 ? 103 TRP H CZ2 1 
ATOM   818  C CZ3 . TRP A 1 110 ? 73.017  70.693  117.065 1.00 21.49 ? 103 TRP H CZ3 1 
ATOM   819  C CH2 . TRP A 1 110 ? 71.862  70.058  117.550 1.00 20.87 ? 103 TRP H CH2 1 
ATOM   820  N N   . GLY A 1 111 ? 78.246  67.561  113.478 1.00 22.80 ? 104 GLY H N   1 
ATOM   821  C CA  . GLY A 1 111 ? 79.383  68.223  112.887 1.00 21.58 ? 104 GLY H CA  1 
ATOM   822  C C   . GLY A 1 111 ? 79.773  69.401  113.747 1.00 20.76 ? 104 GLY H C   1 
ATOM   823  O O   . GLY A 1 111 ? 79.077  69.769  114.700 1.00 20.03 ? 104 GLY H O   1 
ATOM   824  N N   . GLN A 1 112 ? 80.904  69.987  113.412 1.00 19.64 ? 105 GLN H N   1 
ATOM   825  C CA  . GLN A 1 112 ? 81.468  71.067  114.215 1.00 20.60 ? 105 GLN H CA  1 
ATOM   826  C C   . GLN A 1 112 ? 80.723  72.379  114.013 1.00 20.07 ? 105 GLN H C   1 
ATOM   827  O O   . GLN A 1 112 ? 80.941  73.329  114.737 1.00 19.66 ? 105 GLN H O   1 
ATOM   828  C CB  . GLN A 1 112 ? 82.959  71.231  113.897 1.00 22.01 ? 105 GLN H CB  1 
ATOM   829  C CG  . GLN A 1 112 ? 83.264  71.945  112.584 1.00 22.80 ? 105 GLN H CG  1 
ATOM   830  C CD  . GLN A 1 112 ? 83.319  71.044  111.355 1.00 23.31 ? 105 GLN H CD  1 
ATOM   831  O OE1 . GLN A 1 112 ? 82.720  69.964  111.296 1.00 22.63 ? 105 GLN H OE1 1 
ATOM   832  N NE2 . GLN A 1 112 ? 84.051  71.500  110.354 1.00 24.60 ? 105 GLN H NE2 1 
ATOM   833  N N   . GLY A 1 113 ? 79.855  72.426  113.001 1.00 20.01 ? 106 GLY H N   1 
ATOM   834  C CA  . GLY A 1 113 ? 79.092  73.616  112.670 1.00 19.41 ? 106 GLY H CA  1 
ATOM   835  C C   . GLY A 1 113 ? 79.775  74.437  111.592 1.00 19.37 ? 106 GLY H C   1 
ATOM   836  O O   . GLY A 1 113 ? 80.994  74.443  111.508 1.00 18.44 ? 106 GLY H O   1 
ATOM   837  N N   . THR A 1 114 ? 78.978  75.117  110.766 1.00 19.65 ? 107 THR H N   1 
ATOM   838  C CA  . THR A 1 114 ? 79.462  76.049  109.759 1.00 19.50 ? 107 THR H CA  1 
ATOM   839  C C   . THR A 1 114 ? 78.790  77.386  109.997 1.00 20.63 ? 107 THR H C   1 
ATOM   840  O O   . THR A 1 114 ? 77.550  77.474  110.041 1.00 20.36 ? 107 THR H O   1 
ATOM   841  C CB  . THR A 1 114 ? 79.100  75.568  108.348 1.00 19.33 ? 107 THR H CB  1 
ATOM   842  O OG1 . THR A 1 114 ? 79.698  74.303  108.100 1.00 18.10 ? 107 THR H OG1 1 
ATOM   843  C CG2 . THR A 1 114 ? 79.589  76.540  107.277 1.00 20.68 ? 107 THR H CG2 1 
ATOM   844  N N   . THR A 1 115 ? 79.591  78.438  110.114 1.00 21.39 ? 108 THR H N   1 
ATOM   845  C CA  . THR A 1 115 ? 79.043  79.778  110.307 1.00 23.13 ? 108 THR H CA  1 
ATOM   846  C C   . THR A 1 115 ? 78.768  80.503  108.993 1.00 23.39 ? 108 THR H C   1 
ATOM   847  O O   . THR A 1 115 ? 79.658  80.651  108.153 1.00 23.55 ? 108 THR H O   1 
ATOM   848  C CB  . THR A 1 115 ? 79.977  80.665  111.107 1.00 23.65 ? 108 THR H CB  1 
ATOM   849  O OG1 . THR A 1 115 ? 80.169  80.090  112.389 1.00 25.67 ? 108 THR H OG1 1 
ATOM   850  C CG2 . THR A 1 115 ? 79.373  82.040  111.312 1.00 24.88 ? 108 THR H CG2 1 
ATOM   851  N N   . VAL A 1 116 ? 77.551  81.016  108.868 1.00 22.39 ? 109 VAL H N   1 
ATOM   852  C CA  . VAL A 1 116 ? 77.155  81.749  107.692 1.00 23.32 ? 109 VAL H CA  1 
ATOM   853  C C   . VAL A 1 116 ? 76.880  83.153  108.161 1.00 23.62 ? 109 VAL H C   1 
ATOM   854  O O   . VAL A 1 116 ? 76.047  83.356  109.033 1.00 23.76 ? 109 VAL H O   1 
ATOM   855  C CB  . VAL A 1 116 ? 75.929  81.119  107.003 1.00 23.21 ? 109 VAL H CB  1 
ATOM   856  C CG1 . VAL A 1 116 ? 75.425  81.994  105.859 1.00 23.31 ? 109 VAL H CG1 1 
ATOM   857  C CG2 . VAL A 1 116 ? 76.306  79.754  106.477 1.00 23.20 ? 109 VAL H CG2 1 
ATOM   858  N N   . THR A 1 117 ? 77.600  84.107  107.569 1.00 24.33 ? 110 THR H N   1 
ATOM   859  C CA  . THR A 1 117 ? 77.482  85.525  107.880 1.00 24.97 ? 110 THR H CA  1 
ATOM   860  C C   . THR A 1 117 ? 76.936  86.278  106.663 1.00 25.59 ? 110 THR H C   1 
ATOM   861  O O   . THR A 1 117 ? 77.610  86.379  105.652 1.00 25.65 ? 110 THR H O   1 
ATOM   862  C CB  . THR A 1 117 ? 78.855  86.100  108.253 1.00 24.85 ? 110 THR H CB  1 
ATOM   863  O OG1 . THR A 1 117 ? 79.476  85.234  109.208 1.00 25.99 ? 110 THR H OG1 1 
ATOM   864  C CG2 . THR A 1 117 ? 78.719  87.507  108.839 1.00 24.49 ? 110 THR H CG2 1 
ATOM   865  N N   . VAL A 1 118 ? 75.718  86.799  106.774 1.00 27.24 ? 111 VAL H N   1 
ATOM   866  C CA  . VAL A 1 118 ? 75.061  87.502  105.674 1.00 28.35 ? 111 VAL H CA  1 
ATOM   867  C C   . VAL A 1 118 ? 75.273  88.998  105.859 1.00 29.48 ? 111 VAL H C   1 
ATOM   868  O O   . VAL A 1 118 ? 74.730  89.602  106.790 1.00 30.58 ? 111 VAL H O   1 
ATOM   869  C CB  . VAL A 1 118 ? 73.558  87.153  105.569 1.00 28.38 ? 111 VAL H CB  1 
ATOM   870  C CG1 . VAL A 1 118 ? 72.909  87.871  104.391 1.00 28.68 ? 111 VAL H CG1 1 
ATOM   871  C CG2 . VAL A 1 118 ? 73.380  85.651  105.373 1.00 28.59 ? 111 VAL H CG2 1 
ATOM   872  N N   . SER A 1 119 ? 76.064  89.585  104.958 1.00 31.02 ? 112 SER H N   1 
ATOM   873  C CA  . SER A 1 119 ? 76.411  91.012  105.011 1.00 32.02 ? 112 SER H CA  1 
ATOM   874  C C   . SER A 1 119 ? 76.743  91.589  103.641 1.00 34.03 ? 112 SER H C   1 
ATOM   875  O O   . SER A 1 119 ? 77.294  90.899  102.780 1.00 33.61 ? 112 SER H O   1 
ATOM   876  C CB  . SER A 1 119 ? 77.634  91.239  105.909 1.00 30.65 ? 112 SER H CB  1 
ATOM   877  O OG  . SER A 1 119 ? 77.853  92.627  106.160 1.00 29.19 ? 112 SER H OG  1 
ATOM   878  N N   . SER A 1 120 ? 76.443  92.880  103.497 1.00 37.78 ? 113 SER H N   1 
ATOM   879  C CA  . SER A 1 120 ? 76.876  93.704  102.364 1.00 41.28 ? 113 SER H CA  1 
ATOM   880  C C   . SER A 1 120 ? 78.338  94.072  102.456 1.00 40.70 ? 113 SER H C   1 
ATOM   881  O O   . SER A 1 120 ? 79.059  94.056  101.453 1.00 44.17 ? 113 SER H O   1 
ATOM   882  C CB  . SER A 1 120 ? 76.121  95.028  102.383 1.00 43.20 ? 113 SER H CB  1 
ATOM   883  O OG  . SER A 1 120 ? 74.751  94.835  102.152 1.00 44.77 ? 113 SER H OG  1 
ATOM   884  N N   . ALA A 1 121 ? 78.728  94.455  103.672 1.00 38.26 ? 114 ALA H N   1 
ATOM   885  C CA  . ALA A 1 121 ? 80.047  94.988  104.011 1.00 36.97 ? 114 ALA H CA  1 
ATOM   886  C C   . ALA A 1 121 ? 81.206  94.337  103.273 1.00 35.38 ? 114 ALA H C   1 
ATOM   887  O O   . ALA A 1 121 ? 81.188  93.150  103.001 1.00 38.73 ? 114 ALA H O   1 
ATOM   888  C CB  . ALA A 1 121 ? 80.264  94.877  105.513 1.00 36.13 ? 114 ALA H CB  1 
ATOM   889  N N   . SER A 1 122 ? 82.204  95.137  102.945 1.00 35.01 ? 115 SER H N   1 
ATOM   890  C CA  . SER A 1 122 ? 83.428  94.631  102.361 1.00 37.34 ? 115 SER H CA  1 
ATOM   891  C C   . SER A 1 122 ? 84.525  94.565  103.424 1.00 37.07 ? 115 SER H C   1 
ATOM   892  O O   . SER A 1 122 ? 84.451  95.211  104.485 1.00 37.16 ? 115 SER H O   1 
ATOM   893  C CB  . SER A 1 122 ? 83.854  95.489  101.178 1.00 38.81 ? 115 SER H CB  1 
ATOM   894  O OG  . SER A 1 122 ? 83.901  96.862  101.534 1.00 40.96 ? 115 SER H OG  1 
ATOM   895  N N   . THR A 1 123 ? 85.532  93.756  103.125 1.00 35.81 ? 116 THR H N   1 
ATOM   896  C CA  . THR A 1 123 ? 86.649  93.555  104.018 1.00 35.24 ? 116 THR H CA  1 
ATOM   897  C C   . THR A 1 123 ? 87.258  94.893  104.330 1.00 34.41 ? 116 THR H C   1 
ATOM   898  O O   . THR A 1 123 ? 87.376  95.755  103.465 1.00 33.58 ? 116 THR H O   1 
ATOM   899  C CB  . THR A 1 123 ? 87.734  92.679  103.401 1.00 35.12 ? 116 THR H CB  1 
ATOM   900  O OG1 . THR A 1 123 ? 87.166  91.421  103.052 1.00 37.19 ? 116 THR H OG1 1 
ATOM   901  C CG2 . THR A 1 123 ? 88.874  92.444  104.381 1.00 35.07 ? 116 THR H CG2 1 
ATOM   902  N N   . LYS A 1 124 ? 87.643  95.044  105.583 1.00 33.85 ? 117 LYS H N   1 
ATOM   903  C CA  . LYS A 1 124 ? 88.134  96.301  106.064 1.00 33.85 ? 117 LYS H CA  1 
ATOM   904  C C   . LYS A 1 124 ? 88.845  96.138  107.405 1.00 31.47 ? 117 LYS H C   1 
ATOM   905  O O   . LYS A 1 124 ? 88.306  95.538  108.336 1.00 29.11 ? 117 LYS H O   1 
ATOM   906  C CB  . LYS A 1 124 ? 86.968  97.283  106.165 1.00 34.90 ? 117 LYS H CB  1 
ATOM   907  C CG  . LYS A 1 124 ? 87.326  98.507  106.966 1.00 36.04 ? 117 LYS H CG  1 
ATOM   908  C CD  . LYS A 1 124 ? 86.486  99.718  106.633 1.00 36.89 ? 117 LYS H CD  1 
ATOM   909  C CE  . LYS A 1 124 ? 87.193  100.949 107.172 1.00 37.96 ? 117 LYS H CE  1 
ATOM   910  N NZ  . LYS A 1 124 ? 87.454  100.888 108.643 1.00 39.12 ? 117 LYS H NZ  1 
ATOM   911  N N   . GLY A 1 125 ? 90.056  96.685  107.483 1.00 30.04 ? 118 GLY H N   1 
ATOM   912  C CA  . GLY A 1 125 ? 90.832  96.681  108.706 1.00 28.43 ? 118 GLY H CA  1 
ATOM   913  C C   . GLY A 1 125 ? 90.283  97.640  109.755 1.00 27.77 ? 118 GLY H C   1 
ATOM   914  O O   . GLY A 1 125 ? 89.596  98.605  109.423 1.00 28.41 ? 118 GLY H O   1 
ATOM   915  N N   . PRO A 1 126 ? 90.589  97.388  111.037 1.00 25.93 ? 119 PRO H N   1 
ATOM   916  C CA  . PRO A 1 126 ? 90.151  98.274  112.112 1.00 26.08 ? 119 PRO H CA  1 
ATOM   917  C C   . PRO A 1 126 ? 91.008  99.545  112.239 1.00 27.07 ? 119 PRO H C   1 
ATOM   918  O O   . PRO A 1 126 ? 92.141  99.558  111.767 1.00 27.74 ? 119 PRO H O   1 
ATOM   919  C CB  . PRO A 1 126 ? 90.382  97.420  113.356 1.00 25.03 ? 119 PRO H CB  1 
ATOM   920  C CG  . PRO A 1 126 ? 91.599  96.634  113.010 1.00 25.37 ? 119 PRO H CG  1 
ATOM   921  C CD  . PRO A 1 126 ? 91.454  96.309  111.547 1.00 25.52 ? 119 PRO H CD  1 
ATOM   922  N N   . SER A 1 127 ? 90.460  100.577 112.879 1.00 26.05 ? 120 SER H N   1 
ATOM   923  C CA  . SER A 1 127 ? 91.278  101.603 113.533 1.00 26.81 ? 120 SER H CA  1 
ATOM   924  C C   . SER A 1 127 ? 91.407  101.194 114.996 1.00 25.35 ? 120 SER H C   1 
ATOM   925  O O   . SER A 1 127 ? 90.481  100.610 115.574 1.00 24.48 ? 120 SER H O   1 
ATOM   926  C CB  . SER A 1 127 ? 90.651  102.996 113.438 1.00 27.85 ? 120 SER H CB  1 
ATOM   927  O OG  . SER A 1 127 ? 90.190  103.266 112.121 1.00 29.65 ? 120 SER H OG  1 
ATOM   928  N N   . VAL A 1 128 ? 92.559  101.501 115.578 1.00 23.65 ? 121 VAL H N   1 
ATOM   929  C CA  . VAL A 1 128 ? 92.868  101.136 116.951 1.00 24.36 ? 121 VAL H CA  1 
ATOM   930  C C   . VAL A 1 128 ? 93.063  102.407 117.763 1.00 24.10 ? 121 VAL H C   1 
ATOM   931  O O   . VAL A 1 128 ? 93.973  103.176 117.481 1.00 24.02 ? 121 VAL H O   1 
ATOM   932  C CB  . VAL A 1 128 ? 94.147  100.280 117.044 1.00 24.38 ? 121 VAL H CB  1 
ATOM   933  C CG1 . VAL A 1 128 ? 94.365  99.813  118.468 1.00 24.10 ? 121 VAL H CG1 1 
ATOM   934  C CG2 . VAL A 1 128 ? 94.064  99.077  116.122 1.00 24.81 ? 121 VAL H CG2 1 
ATOM   935  N N   . PHE A 1 129 ? 92.238  102.582 118.791 1.00 24.23 ? 122 PHE H N   1 
ATOM   936  C CA  . PHE A 1 129 ? 92.249  103.774 119.626 1.00 24.95 ? 122 PHE H CA  1 
ATOM   937  C C   . PHE A 1 129 ? 92.564  103.369 121.065 1.00 26.44 ? 122 PHE H C   1 
ATOM   938  O O   . PHE A 1 129 ? 92.091  102.344 121.550 1.00 25.96 ? 122 PHE H O   1 
ATOM   939  C CB  . PHE A 1 129 ? 90.899  104.509 119.564 1.00 24.84 ? 122 PHE H CB  1 
ATOM   940  C CG  . PHE A 1 129 ? 90.469  104.878 118.153 1.00 25.66 ? 122 PHE H CG  1 
ATOM   941  C CD1 . PHE A 1 129 ? 91.267  105.713 117.353 1.00 26.17 ? 122 PHE H CD1 1 
ATOM   942  C CD2 . PHE A 1 129 ? 89.269  104.402 117.623 1.00 24.95 ? 122 PHE H CD2 1 
ATOM   943  C CE1 . PHE A 1 129 ? 90.879  106.040 116.051 1.00 26.73 ? 122 PHE H CE1 1 
ATOM   944  C CE2 . PHE A 1 129 ? 88.876  104.731 116.331 1.00 24.87 ? 122 PHE H CE2 1 
ATOM   945  C CZ  . PHE A 1 129 ? 89.680  105.546 115.540 1.00 26.14 ? 122 PHE H CZ  1 
ATOM   946  N N   . PRO A 1 130 ? 93.363  104.183 121.757 1.00 27.89 ? 123 PRO H N   1 
ATOM   947  C CA  . PRO A 1 130 ? 93.716  103.905 123.133 1.00 28.36 ? 123 PRO H CA  1 
ATOM   948  C C   . PRO A 1 130 ? 92.573  104.193 124.095 1.00 29.00 ? 123 PRO H C   1 
ATOM   949  O O   . PRO A 1 130 ? 91.766  105.099 123.859 1.00 30.01 ? 123 PRO H O   1 
ATOM   950  C CB  . PRO A 1 130 ? 94.875  104.859 123.380 1.00 29.05 ? 123 PRO H CB  1 
ATOM   951  C CG  . PRO A 1 130 ? 94.584  106.022 122.495 1.00 28.73 ? 123 PRO H CG  1 
ATOM   952  C CD  . PRO A 1 130 ? 93.961  105.444 121.274 1.00 28.36 ? 123 PRO H CD  1 
ATOM   953  N N   . LEU A 1 131 ? 92.519  103.406 125.160 1.00 28.99 ? 124 LEU H N   1 
ATOM   954  C CA  . LEU A 1 131 ? 91.590  103.598 126.254 1.00 30.23 ? 124 LEU H CA  1 
ATOM   955  C C   . LEU A 1 131 ? 92.540  103.886 127.380 1.00 32.61 ? 124 LEU H C   1 
ATOM   956  O O   . LEU A 1 131 ? 92.992  102.976 128.084 1.00 32.90 ? 124 LEU H O   1 
ATOM   957  C CB  . LEU A 1 131 ? 90.768  102.335 126.516 1.00 29.74 ? 124 LEU H CB  1 
ATOM   958  C CG  . LEU A 1 131 ? 89.744  101.943 125.451 1.00 30.06 ? 124 LEU H CG  1 
ATOM   959  C CD1 . LEU A 1 131 ? 89.094  100.611 125.790 1.00 30.58 ? 124 LEU H CD1 1 
ATOM   960  C CD2 . LEU A 1 131 ? 88.676  103.022 125.290 1.00 31.78 ? 124 LEU H CD2 1 
ATOM   961  N N   . ALA A 1 132 ? 92.916  105.154 127.494 1.00 33.57 ? 125 ALA H N   1 
ATOM   962  C CA  . ALA A 1 132 ? 93.979  105.526 128.413 1.00 34.47 ? 125 ALA H CA  1 
ATOM   963  C C   . ALA A 1 132 ? 93.562  105.457 129.874 1.00 34.95 ? 125 ALA H C   1 
ATOM   964  O O   . ALA A 1 132 ? 92.403  105.718 130.203 1.00 32.99 ? 125 ALA H O   1 
ATOM   965  C CB  . ALA A 1 132 ? 94.504  106.908 128.082 1.00 35.93 ? 125 ALA H CB  1 
ATOM   966  N N   . PRO A 1 133 ? 94.515  105.094 130.760 1.00 37.68 ? 126 PRO H N   1 
ATOM   967  C CA  . PRO A 1 133 ? 94.168  105.146 132.182 1.00 41.14 ? 126 PRO H CA  1 
ATOM   968  C C   . PRO A 1 133 ? 94.187  106.570 132.710 1.00 44.63 ? 126 PRO H C   1 
ATOM   969  O O   . PRO A 1 133 ? 94.877  107.420 132.133 1.00 44.69 ? 126 PRO H O   1 
ATOM   970  C CB  . PRO A 1 133 ? 95.287  104.333 132.846 1.00 40.14 ? 126 PRO H CB  1 
ATOM   971  C CG  . PRO A 1 133 ? 96.457  104.469 131.935 1.00 39.55 ? 126 PRO H CG  1 
ATOM   972  C CD  . PRO A 1 133 ? 95.925  104.677 130.543 1.00 37.77 ? 126 PRO H CD  1 
ATOM   973  N N   . SER A 1 134 ? 93.445  106.826 133.786 1.00 49.92 ? 127 SER H N   1 
ATOM   974  C CA  . SER A 1 134 ? 93.522  108.122 134.480 1.00 57.14 ? 127 SER H CA  1 
ATOM   975  C C   . SER A 1 134 ? 93.629  107.956 135.998 1.00 58.74 ? 127 SER H C   1 
ATOM   976  O O   . SER A 1 134 ? 92.636  107.709 136.682 1.00 62.49 ? 127 SER H O   1 
ATOM   977  C CB  . SER A 1 134 ? 92.331  109.011 134.103 1.00 62.50 ? 127 SER H CB  1 
ATOM   978  O OG  . SER A 1 134 ? 92.539  110.348 134.544 1.00 66.37 ? 127 SER H OG  1 
ATOM   979  N N   . GLY A 1 140 ? 91.611  103.831 143.875 1.00 67.61 ? 133 GLY H N   1 
ATOM   980  C CA  . GLY A 1 140 ? 93.016  103.829 144.270 1.00 68.55 ? 133 GLY H CA  1 
ATOM   981  C C   . GLY A 1 140 ? 93.598  102.425 144.370 1.00 69.91 ? 133 GLY H C   1 
ATOM   982  O O   . GLY A 1 140 ? 92.959  101.527 144.925 1.00 72.02 ? 133 GLY H O   1 
ATOM   983  N N   . GLY A 1 141 ? 94.807  102.242 143.827 1.00 67.98 ? 134 GLY H N   1 
ATOM   984  C CA  . GLY A 1 141 ? 95.532  100.962 143.892 1.00 62.74 ? 134 GLY H CA  1 
ATOM   985  C C   . GLY A 1 141 ? 95.677  100.232 142.564 1.00 61.40 ? 134 GLY H C   1 
ATOM   986  O O   . GLY A 1 141 ? 96.778  99.796  142.221 1.00 61.16 ? 134 GLY H O   1 
ATOM   987  N N   . THR A 1 142 ? 94.566  100.088 141.833 1.00 56.35 ? 135 THR H N   1 
ATOM   988  C CA  . THR A 1 142 ? 94.535  99.397  140.531 1.00 50.34 ? 135 THR H CA  1 
ATOM   989  C C   . THR A 1 142 ? 93.944  100.296 139.449 1.00 45.25 ? 135 THR H C   1 
ATOM   990  O O   . THR A 1 142 ? 92.863  100.861 139.622 1.00 47.24 ? 135 THR H O   1 
ATOM   991  C CB  . THR A 1 142 ? 93.749  98.067  140.608 1.00 51.10 ? 135 THR H CB  1 
ATOM   992  O OG1 . THR A 1 142 ? 94.526  97.114  141.335 1.00 53.27 ? 135 THR H OG1 1 
ATOM   993  C CG2 . THR A 1 142 ? 93.459  97.473  139.222 1.00 51.46 ? 135 THR H CG2 1 
ATOM   994  N N   . ALA A 1 143 ? 94.662  100.397 138.334 1.00 38.71 ? 136 ALA H N   1 
ATOM   995  C CA  . ALA A 1 143 ? 94.240  101.166 137.171 1.00 35.26 ? 136 ALA H CA  1 
ATOM   996  C C   . ALA A 1 143 ? 93.767  100.223 136.072 1.00 32.26 ? 136 ALA H C   1 
ATOM   997  O O   . ALA A 1 143 ? 94.182  99.060  136.023 1.00 31.71 ? 136 ALA H O   1 
ATOM   998  C CB  . ALA A 1 143 ? 95.392  102.015 136.661 1.00 34.45 ? 136 ALA H CB  1 
ATOM   999  N N   . ALA A 1 144 ? 92.915  100.737 135.188 1.00 28.82 ? 137 ALA H N   1 
ATOM   1000 C CA  . ALA A 1 144 ? 92.507  100.031 133.978 1.00 27.53 ? 137 ALA H CA  1 
ATOM   1001 C C   . ALA A 1 144 ? 92.883  100.809 132.717 1.00 26.66 ? 137 ALA H C   1 
ATOM   1002 O O   . ALA A 1 144 ? 92.863  102.034 132.706 1.00 25.35 ? 137 ALA H O   1 
ATOM   1003 C CB  . ALA A 1 144 ? 91.011  99.753  134.008 1.00 28.16 ? 137 ALA H CB  1 
ATOM   1004 N N   . LEU A 1 145 ? 93.220  100.072 131.656 1.00 25.32 ? 138 LEU H N   1 
ATOM   1005 C CA  . LEU A 1 145 ? 93.526  100.635 130.344 1.00 24.63 ? 138 LEU H CA  1 
ATOM   1006 C C   . LEU A 1 145 ? 93.214  99.618  129.261 1.00 24.15 ? 138 LEU H C   1 
ATOM   1007 O O   . LEU A 1 145 ? 92.971  98.442  129.541 1.00 24.99 ? 138 LEU H O   1 
ATOM   1008 C CB  . LEU A 1 145 ? 94.993  101.035 130.250 1.00 25.75 ? 138 LEU H CB  1 
ATOM   1009 C CG  . LEU A 1 145 ? 96.008  99.934  130.587 1.00 25.88 ? 138 LEU H CG  1 
ATOM   1010 C CD1 . LEU A 1 145 ? 96.720  99.401  129.363 1.00 25.96 ? 138 LEU H CD1 1 
ATOM   1011 C CD2 . LEU A 1 145 ? 97.030  100.477 131.559 1.00 27.50 ? 138 LEU H CD2 1 
ATOM   1012 N N   . GLY A 1 146 ? 93.210  100.069 128.020 1.00 22.86 ? 139 GLY H N   1 
ATOM   1013 C CA  . GLY A 1 146 ? 92.832  99.204  126.934 1.00 22.93 ? 139 GLY H CA  1 
ATOM   1014 C C   . GLY A 1 146 ? 93.022  99.780  125.569 1.00 23.27 ? 139 GLY H C   1 
ATOM   1015 O O   . GLY A 1 146 ? 93.623  100.849 125.405 1.00 23.25 ? 139 GLY H O   1 
ATOM   1016 N N   . CYS A 1 147 ? 92.516  99.026  124.598 1.00 23.03 ? 140 CYS H N   1 
ATOM   1017 C CA  . CYS A 1 147 ? 92.421  99.429  123.204 1.00 23.62 ? 140 CYS H CA  1 
ATOM   1018 C C   . CYS A 1 147 ? 91.010  99.201  122.705 1.00 22.58 ? 140 CYS H C   1 
ATOM   1019 O O   . CYS A 1 147 ? 90.397  98.152  122.985 1.00 22.53 ? 140 CYS H O   1 
ATOM   1020 C CB  . CYS A 1 147 ? 93.387  98.607  122.334 1.00 25.36 ? 140 CYS H CB  1 
ATOM   1021 S SG  . CYS A 1 147 ? 95.049  99.215  122.565 1.00 30.04 ? 140 CYS H SG  1 
ATOM   1022 N N   . LEU A 1 148 ? 90.512  100.186 121.968 1.00 21.71 ? 141 LEU H N   1 
ATOM   1023 C CA  . LEU A 1 148 ? 89.263  100.085 121.212 1.00 21.51 ? 141 LEU H CA  1 
ATOM   1024 C C   . LEU A 1 148 ? 89.629  99.768  119.764 1.00 20.96 ? 141 LEU H C   1 
ATOM   1025 O O   . LEU A 1 148 ? 90.379  100.512 119.130 1.00 20.73 ? 141 LEU H O   1 
ATOM   1026 C CB  . LEU A 1 148 ? 88.481  101.394 121.307 1.00 20.78 ? 141 LEU H CB  1 
ATOM   1027 C CG  . LEU A 1 148 ? 87.250  101.572 120.426 1.00 21.23 ? 141 LEU H CG  1 
ATOM   1028 C CD1 . LEU A 1 148 ? 86.186  100.528 120.749 1.00 21.92 ? 141 LEU H CD1 1 
ATOM   1029 C CD2 . LEU A 1 148 ? 86.685  102.974 120.623 1.00 21.84 ? 141 LEU H CD2 1 
ATOM   1030 N N   . VAL A 1 149 ? 89.125  98.641  119.270 1.00 20.40 ? 142 VAL H N   1 
ATOM   1031 C CA  . VAL A 1 149 ? 89.438  98.152  117.934 1.00 20.72 ? 142 VAL H CA  1 
ATOM   1032 C C   . VAL A 1 149 ? 88.157  98.268  117.118 1.00 21.74 ? 142 VAL H C   1 
ATOM   1033 O O   . VAL A 1 149 ? 87.242  97.454  117.270 1.00 21.48 ? 142 VAL H O   1 
ATOM   1034 C CB  . VAL A 1 149 ? 89.944  96.701  117.979 1.00 20.11 ? 142 VAL H CB  1 
ATOM   1035 C CG1 . VAL A 1 149 ? 90.362  96.217  116.591 1.00 20.03 ? 142 VAL H CG1 1 
ATOM   1036 C CG2 . VAL A 1 149 ? 91.111  96.591  118.945 1.00 20.53 ? 142 VAL H CG2 1 
ATOM   1037 N N   . LYS A 1 150 ? 88.098  99.281  116.257 1.00 22.92 ? 143 LYS H N   1 
ATOM   1038 C CA  . LYS A 1 150 ? 86.829  99.766  115.749 1.00 24.43 ? 143 LYS H CA  1 
ATOM   1039 C C   . LYS A 1 150 ? 86.697  99.638  114.237 1.00 25.73 ? 143 LYS H C   1 
ATOM   1040 O O   . LYS A 1 150 ? 87.679  99.779  113.507 1.00 25.17 ? 143 LYS H O   1 
ATOM   1041 C CB  . LYS A 1 150 ? 86.659  101.224 116.163 1.00 26.25 ? 143 LYS H CB  1 
ATOM   1042 C CG  . LYS A 1 150 ? 85.246  101.731 115.995 1.00 28.05 ? 143 LYS H CG  1 
ATOM   1043 C CD  . LYS A 1 150 ? 84.895  102.865 116.944 1.00 29.33 ? 143 LYS H CD  1 
ATOM   1044 C CE  . LYS A 1 150 ? 83.434  103.294 116.792 1.00 29.79 ? 143 LYS H CE  1 
ATOM   1045 N NZ  . LYS A 1 150 ? 83.006  103.520 115.387 1.00 30.63 ? 143 LYS H NZ  1 
ATOM   1046 N N   . ASP A 1 151 ? 85.474  99.356  113.789 1.00 25.55 ? 144 ASP H N   1 
ATOM   1047 C CA  . ASP A 1 151 ? 85.096  99.409  112.363 1.00 26.51 ? 144 ASP H CA  1 
ATOM   1048 C C   . ASP A 1 151 ? 85.887  98.491  111.460 1.00 27.15 ? 144 ASP H C   1 
ATOM   1049 O O   . ASP A 1 151 ? 86.518  98.949  110.500 1.00 29.69 ? 144 ASP H O   1 
ATOM   1050 C CB  . ASP A 1 151 ? 85.178  100.851 111.828 1.00 27.30 ? 144 ASP H CB  1 
ATOM   1051 C CG  . ASP A 1 151 ? 84.269  101.791 112.568 1.00 26.67 ? 144 ASP H CG  1 
ATOM   1052 O OD1 . ASP A 1 151 ? 83.187  101.365 113.005 1.00 28.29 ? 144 ASP H OD1 1 
ATOM   1053 O OD2 . ASP A 1 151 ? 84.628  102.959 112.726 1.00 26.67 ? 144 ASP H OD2 1 
ATOM   1054 N N   . TYR A 1 152 ? 85.818  97.191  111.743 1.00 26.88 ? 145 TYR H N   1 
ATOM   1055 C CA  . TYR A 1 152 ? 86.435  96.173  110.884 1.00 25.69 ? 145 TYR H CA  1 
ATOM   1056 C C   . TYR A 1 152 ? 85.416  95.144  110.389 1.00 25.87 ? 145 TYR H C   1 
ATOM   1057 O O   . TYR A 1 152 ? 84.342  94.975  110.986 1.00 25.79 ? 145 TYR H O   1 
ATOM   1058 C CB  . TYR A 1 152 ? 87.584  95.488  111.622 1.00 24.51 ? 145 TYR H CB  1 
ATOM   1059 C CG  . TYR A 1 152 ? 87.144  94.717  112.834 1.00 23.53 ? 145 TYR H CG  1 
ATOM   1060 C CD1 . TYR A 1 152 ? 87.040  95.346  114.071 1.00 23.01 ? 145 TYR H CD1 1 
ATOM   1061 C CD2 . TYR A 1 152 ? 86.802  93.354  112.751 1.00 22.87 ? 145 TYR H CD2 1 
ATOM   1062 C CE1 . TYR A 1 152 ? 86.644  94.652  115.196 1.00 21.65 ? 145 TYR H CE1 1 
ATOM   1063 C CE2 . TYR A 1 152 ? 86.383  92.646  113.885 1.00 21.58 ? 145 TYR H CE2 1 
ATOM   1064 C CZ  . TYR A 1 152 ? 86.318  93.302  115.104 1.00 21.08 ? 145 TYR H CZ  1 
ATOM   1065 O OH  . TYR A 1 152 ? 85.922  92.663  116.253 1.00 19.20 ? 145 TYR H OH  1 
ATOM   1066 N N   . PHE A 1 153 ? 85.759  94.463  109.298 1.00 25.54 ? 146 PHE H N   1 
ATOM   1067 C CA  . PHE A 1 153 ? 84.925  93.379  108.773 1.00 26.41 ? 146 PHE H CA  1 
ATOM   1068 C C   . PHE A 1 153 ? 85.797  92.426  107.963 1.00 27.25 ? 146 PHE H C   1 
ATOM   1069 O O   . PHE A 1 153 ? 86.683  92.892  107.263 1.00 29.17 ? 146 PHE H O   1 
ATOM   1070 C CB  . PHE A 1 153 ? 83.800  93.936  107.889 1.00 25.96 ? 146 PHE H CB  1 
ATOM   1071 C CG  . PHE A 1 153 ? 82.845  92.883  107.401 1.00 25.22 ? 146 PHE H CG  1 
ATOM   1072 C CD1 . PHE A 1 153 ? 83.084  92.205  106.209 1.00 25.59 ? 146 PHE H CD1 1 
ATOM   1073 C CD2 . PHE A 1 153 ? 81.712  92.548  108.150 1.00 25.18 ? 146 PHE H CD2 1 
ATOM   1074 C CE1 . PHE A 1 153 ? 82.218  91.215  105.769 1.00 25.69 ? 146 PHE H CE1 1 
ATOM   1075 C CE2 . PHE A 1 153 ? 80.840  91.563  107.710 1.00 24.66 ? 146 PHE H CE2 1 
ATOM   1076 C CZ  . PHE A 1 153 ? 81.096  90.894  106.518 1.00 24.89 ? 146 PHE H CZ  1 
ATOM   1077 N N   . PRO A 1 154 ? 85.603  91.104  108.046 1.00 26.88 ? 147 PRO H N   1 
ATOM   1078 C CA  . PRO A 1 154 ? 84.730  90.399  108.968 1.00 26.07 ? 147 PRO H CA  1 
ATOM   1079 C C   . PRO A 1 154 ? 85.427  90.177  110.313 1.00 25.16 ? 147 PRO H C   1 
ATOM   1080 O O   . PRO A 1 154 ? 86.474  90.748  110.557 1.00 24.39 ? 147 PRO H O   1 
ATOM   1081 C CB  . PRO A 1 154 ? 84.539  89.064  108.260 1.00 26.40 ? 147 PRO H CB  1 
ATOM   1082 C CG  . PRO A 1 154 ? 85.853  88.823  107.585 1.00 26.81 ? 147 PRO H CG  1 
ATOM   1083 C CD  . PRO A 1 154 ? 86.464  90.170  107.312 1.00 26.89 ? 147 PRO H CD  1 
ATOM   1084 N N   . GLU A 1 155 ? 84.839  89.366  111.187 1.00 24.47 ? 148 GLU H N   1 
ATOM   1085 C CA  . GLU A 1 155 ? 85.564  88.842  112.356 1.00 24.24 ? 148 GLU H CA  1 
ATOM   1086 C C   . GLU A 1 155 ? 86.571  87.812  111.863 1.00 22.51 ? 148 GLU H C   1 
ATOM   1087 O O   . GLU A 1 155 ? 86.436  87.359  110.736 1.00 22.64 ? 148 GLU H O   1 
ATOM   1088 C CB  . GLU A 1 155 ? 84.607  88.156  113.323 1.00 24.30 ? 148 GLU H CB  1 
ATOM   1089 C CG  . GLU A 1 155 ? 83.615  89.080  113.982 1.00 24.48 ? 148 GLU H CG  1 
ATOM   1090 C CD  . GLU A 1 155 ? 83.204  88.570  115.341 1.00 25.29 ? 148 GLU H CD  1 
ATOM   1091 O OE1 . GLU A 1 155 ? 82.023  88.248  115.513 1.00 28.59 ? 148 GLU H OE1 1 
ATOM   1092 O OE2 . GLU A 1 155 ? 84.062  88.462  116.237 1.00 24.97 ? 148 GLU H OE2 1 
ATOM   1093 N N   . PRO A 1 156 ? 87.576  87.424  112.650 1.00 21.79 ? 149 PRO H N   1 
ATOM   1094 C CA  . PRO A 1 156 ? 87.921  87.965  113.949 1.00 22.14 ? 149 PRO H CA  1 
ATOM   1095 C C   . PRO A 1 156 ? 89.043  89.004  113.856 1.00 22.80 ? 149 PRO H C   1 
ATOM   1096 O O   . PRO A 1 156 ? 89.689  89.137  112.822 1.00 21.79 ? 149 PRO H O   1 
ATOM   1097 C CB  . PRO A 1 156 ? 88.458  86.724  114.671 1.00 21.39 ? 149 PRO H CB  1 
ATOM   1098 C CG  . PRO A 1 156 ? 89.151  85.964  113.594 1.00 21.55 ? 149 PRO H CG  1 
ATOM   1099 C CD  . PRO A 1 156 ? 88.454  86.296  112.297 1.00 21.80 ? 149 PRO H CD  1 
ATOM   1100 N N   . VAL A 1 157 ? 89.243  89.736  114.943 1.00 23.78 ? 150 VAL H N   1 
ATOM   1101 C CA  . VAL A 1 157 ? 90.530  90.383  115.214 1.00 24.64 ? 150 VAL H CA  1 
ATOM   1102 C C   . VAL A 1 157 ? 91.100  89.705  116.445 1.00 23.73 ? 150 VAL H C   1 
ATOM   1103 O O   . VAL A 1 157 ? 90.351  89.235  117.309 1.00 23.04 ? 150 VAL H O   1 
ATOM   1104 C CB  . VAL A 1 157 ? 90.474  91.921  115.500 1.00 24.42 ? 150 VAL H CB  1 
ATOM   1105 C CG1 . VAL A 1 157 ? 90.159  92.696  114.251 1.00 25.27 ? 150 VAL H CG1 1 
ATOM   1106 C CG2 . VAL A 1 157 ? 89.499  92.275  116.601 1.00 24.27 ? 150 VAL H CG2 1 
ATOM   1107 N N   . THR A 1 158 ? 92.423  89.687  116.524 1.00 22.88 ? 151 THR H N   1 
ATOM   1108 C CA  . THR A 1 158 ? 93.093  89.281  117.737 1.00 23.67 ? 151 THR H CA  1 
ATOM   1109 C C   . THR A 1 158 ? 93.813  90.468  118.371 1.00 24.87 ? 151 THR H C   1 
ATOM   1110 O O   . THR A 1 158 ? 94.252  91.397  117.686 1.00 22.62 ? 151 THR H O   1 
ATOM   1111 C CB  . THR A 1 158 ? 94.075  88.131  117.485 1.00 23.58 ? 151 THR H CB  1 
ATOM   1112 O OG1 . THR A 1 158 ? 95.124  88.574  116.632 1.00 22.41 ? 151 THR H OG1 1 
ATOM   1113 C CG2 . THR A 1 158 ? 93.332  86.928  116.842 1.00 23.94 ? 151 THR H CG2 1 
ATOM   1114 N N   . VAL A 1 159 ? 93.892  90.415  119.694 1.00 26.33 ? 152 VAL H N   1 
ATOM   1115 C CA  . VAL A 1 159 ? 94.585  91.395  120.492 1.00 28.70 ? 152 VAL H CA  1 
ATOM   1116 C C   . VAL A 1 159 ? 95.389  90.650  121.537 1.00 29.77 ? 152 VAL H C   1 
ATOM   1117 O O   . VAL A 1 159 ? 94.854  89.792  122.232 1.00 30.01 ? 152 VAL H O   1 
ATOM   1118 C CB  . VAL A 1 159 ? 93.613  92.335  121.234 1.00 30.45 ? 152 VAL H CB  1 
ATOM   1119 C CG1 . VAL A 1 159 ? 94.382  93.413  121.990 1.00 30.83 ? 152 VAL H CG1 1 
ATOM   1120 C CG2 . VAL A 1 159 ? 92.644  92.990  120.257 1.00 31.45 ? 152 VAL H CG2 1 
ATOM   1121 N N   . SER A 1 160 ? 96.672  90.974  121.642 1.00 30.46 ? 153 SER H N   1 
ATOM   1122 C CA  . SER A 1 160 ? 97.451  90.634  122.830 1.00 30.10 ? 153 SER H CA  1 
ATOM   1123 C C   . SER A 1 160 ? 98.057  91.917  123.413 1.00 31.09 ? 153 SER H C   1 
ATOM   1124 O O   . SER A 1 160 ? 98.002  92.984  122.783 1.00 31.79 ? 153 SER H O   1 
ATOM   1125 C CB  . SER A 1 160 ? 98.543  89.621  122.492 1.00 29.82 ? 153 SER H CB  1 
ATOM   1126 O OG  . SER A 1 160 ? 99.444  90.161  121.567 1.00 31.39 ? 153 SER H OG  1 
ATOM   1127 N N   . TRP A 1 161 ? 98.617  91.788  124.617 1.00 30.29 ? 154 TRP H N   1 
ATOM   1128 C CA  . TRP A 1 161 ? 99.259  92.870  125.358 1.00 28.95 ? 154 TRP H CA  1 
ATOM   1129 C C   . TRP A 1 161 ? 100.725 92.554  125.574 1.00 31.18 ? 154 TRP H C   1 
ATOM   1130 O O   . TRP A 1 161 ? 101.074 91.449  126.032 1.00 30.25 ? 154 TRP H O   1 
ATOM   1131 C CB  . TRP A 1 161 ? 98.566  93.072  126.699 1.00 29.61 ? 154 TRP H CB  1 
ATOM   1132 C CG  . TRP A 1 161 ? 97.260  93.689  126.494 1.00 30.83 ? 154 TRP H CG  1 
ATOM   1133 C CD1 . TRP A 1 161 ? 96.078  93.052  126.286 1.00 30.47 ? 154 TRP H CD1 1 
ATOM   1134 C CD2 . TRP A 1 161 ? 97.001  95.076  126.363 1.00 29.91 ? 154 TRP H CD2 1 
ATOM   1135 N NE1 . TRP A 1 161 ? 95.084  93.962  126.075 1.00 29.53 ? 154 TRP H NE1 1 
ATOM   1136 C CE2 . TRP A 1 161 ? 95.626  95.217  126.107 1.00 29.52 ? 154 TRP H CE2 1 
ATOM   1137 C CE3 . TRP A 1 161 ? 97.797  96.221  126.453 1.00 30.20 ? 154 TRP H CE3 1 
ATOM   1138 C CZ2 . TRP A 1 161 ? 95.025  96.452  125.943 1.00 28.94 ? 154 TRP H CZ2 1 
ATOM   1139 C CZ3 . TRP A 1 161 ? 97.204  97.446  126.284 1.00 29.86 ? 154 TRP H CZ3 1 
ATOM   1140 C CH2 . TRP A 1 161 ? 95.828  97.556  126.041 1.00 29.88 ? 154 TRP H CH2 1 
ATOM   1141 N N   . ASN A 1 162 ? 101.568 93.531  125.231 1.00 32.17 ? 155 ASN H N   1 
ATOM   1142 C CA  . ASN A 1 162 ? 103.026 93.425  125.303 1.00 32.41 ? 155 ASN H CA  1 
ATOM   1143 C C   . ASN A 1 162 ? 103.563 92.132  124.697 1.00 34.82 ? 155 ASN H C   1 
ATOM   1144 O O   . ASN A 1 162 ? 104.350 91.423  125.310 1.00 34.13 ? 155 ASN H O   1 
ATOM   1145 C CB  . ASN A 1 162 ? 103.501 93.612  126.750 1.00 31.81 ? 155 ASN H CB  1 
ATOM   1146 C CG  . ASN A 1 162 ? 103.292 95.023  127.249 1.00 30.65 ? 155 ASN H CG  1 
ATOM   1147 O OD1 . ASN A 1 162 ? 102.992 95.929  126.471 1.00 29.89 ? 155 ASN H OD1 1 
ATOM   1148 N ND2 . ASN A 1 162 ? 103.438 95.217  128.545 1.00 29.72 ? 155 ASN H ND2 1 
ATOM   1149 N N   . SER A 1 163 ? 103.110 91.855  123.479 1.00 37.29 ? 156 SER H N   1 
ATOM   1150 C CA  . SER A 1 163 ? 103.575 90.732  122.667 1.00 39.38 ? 156 SER H CA  1 
ATOM   1151 C C   . SER A 1 163 ? 103.351 89.367  123.355 1.00 41.49 ? 156 SER H C   1 
ATOM   1152 O O   . SER A 1 163 ? 104.211 88.491  123.334 1.00 41.42 ? 156 SER H O   1 
ATOM   1153 C CB  . SER A 1 163 ? 105.042 90.943  122.277 1.00 39.79 ? 156 SER H CB  1 
ATOM   1154 O OG  . SER A 1 163 ? 105.144 91.896  121.243 1.00 40.35 ? 156 SER H OG  1 
ATOM   1155 N N   . GLY A 1 164 ? 102.191 89.211  123.987 1.00 42.52 ? 157 GLY H N   1 
ATOM   1156 C CA  . GLY A 1 164 ? 101.860 87.990  124.728 1.00 40.67 ? 157 GLY H CA  1 
ATOM   1157 C C   . GLY A 1 164 ? 102.385 87.929  126.151 1.00 40.31 ? 157 GLY H C   1 
ATOM   1158 O O   . GLY A 1 164 ? 101.887 87.143  126.959 1.00 41.66 ? 157 GLY H O   1 
ATOM   1159 N N   . ALA A 1 165 ? 103.388 88.748  126.464 1.00 39.33 ? 158 ALA H N   1 
ATOM   1160 C CA  . ALA A 1 165 ? 103.982 88.816  127.802 1.00 37.57 ? 158 ALA H CA  1 
ATOM   1161 C C   . ALA A 1 165 ? 103.016 89.174  128.911 1.00 38.24 ? 158 ALA H C   1 
ATOM   1162 O O   . ALA A 1 165 ? 103.228 88.778  130.059 1.00 40.07 ? 158 ALA H O   1 
ATOM   1163 C CB  . ALA A 1 165 ? 105.117 89.818  127.813 1.00 38.48 ? 158 ALA H CB  1 
ATOM   1164 N N   . LEU A 1 166 ? 101.996 89.966  128.581 1.00 37.49 ? 159 LEU H N   1 
ATOM   1165 C CA  . LEU A 1 166 ? 101.002 90.412  129.553 1.00 36.65 ? 159 LEU H CA  1 
ATOM   1166 C C   . LEU A 1 166 ? 99.659  89.720  129.311 1.00 35.47 ? 159 LEU H C   1 
ATOM   1167 O O   . LEU A 1 166 ? 99.020  89.901  128.275 1.00 35.28 ? 159 LEU H O   1 
ATOM   1168 C CB  . LEU A 1 166 ? 100.841 91.929  129.479 1.00 37.10 ? 159 LEU H CB  1 
ATOM   1169 C CG  . LEU A 1 166 ? 99.791  92.591  130.373 1.00 38.18 ? 159 LEU H CG  1 
ATOM   1170 C CD1 . LEU A 1 166 ? 99.880  92.135  131.825 1.00 38.55 ? 159 LEU H CD1 1 
ATOM   1171 C CD2 . LEU A 1 166 ? 99.911  94.106  130.269 1.00 39.46 ? 159 LEU H CD2 1 
ATOM   1172 N N   . THR A 1 167 ? 99.254  88.917  130.281 1.00 35.20 ? 160 THR H N   1 
ATOM   1173 C CA  . THR A 1 167 ? 98.029  88.106  130.193 1.00 34.78 ? 160 THR H CA  1 
ATOM   1174 C C   . THR A 1 167 ? 97.169  88.215  131.437 1.00 33.44 ? 160 THR H C   1 
ATOM   1175 O O   . THR A 1 167 ? 95.947  88.123  131.366 1.00 35.94 ? 160 THR H O   1 
ATOM   1176 C CB  . THR A 1 167 ? 98.370  86.617  129.971 1.00 35.87 ? 160 THR H CB  1 
ATOM   1177 O OG1 . THR A 1 167 ? 99.154  86.136  131.065 1.00 36.19 ? 160 THR H OG1 1 
ATOM   1178 C CG2 . THR A 1 167 ? 99.154  86.418  128.686 1.00 35.69 ? 160 THR H CG2 1 
ATOM   1179 N N   . SER A 1 168 ? 97.807  88.396  132.582 1.00 33.46 ? 161 SER H N   1 
ATOM   1180 C CA  . SER A 1 168 ? 97.110  88.543  133.838 1.00 33.92 ? 161 SER H CA  1 
ATOM   1181 C C   . SER A 1 168 ? 96.197  89.775  133.845 1.00 34.08 ? 161 SER H C   1 
ATOM   1182 O O   . SER A 1 168 ? 96.636  90.898  133.580 1.00 36.57 ? 161 SER H O   1 
ATOM   1183 C CB  . SER A 1 168 ? 98.111  88.625  134.980 1.00 35.56 ? 161 SER H CB  1 
ATOM   1184 O OG  . SER A 1 168 ? 97.433  88.604  136.224 1.00 38.22 ? 161 SER H OG  1 
ATOM   1185 N N   . GLY A 1 169 ? 94.923  89.542  134.126 1.00 30.88 ? 162 GLY H N   1 
ATOM   1186 C CA  . GLY A 1 169 ? 93.933  90.591  134.149 1.00 30.54 ? 162 GLY H CA  1 
ATOM   1187 C C   . GLY A 1 169 ? 93.474  91.131  132.805 1.00 29.89 ? 162 GLY H C   1 
ATOM   1188 O O   . GLY A 1 169 ? 92.811  92.158  132.778 1.00 30.67 ? 162 GLY H O   1 
ATOM   1189 N N   . VAL A 1 170 ? 93.830  90.471  131.702 1.00 28.63 ? 163 VAL H N   1 
ATOM   1190 C CA  . VAL A 1 170 ? 93.366  90.875  130.374 1.00 28.85 ? 163 VAL H CA  1 
ATOM   1191 C C   . VAL A 1 170 ? 91.953  90.332  130.124 1.00 29.95 ? 163 VAL H C   1 
ATOM   1192 O O   . VAL A 1 170 ? 91.691  89.148  130.351 1.00 32.55 ? 163 VAL H O   1 
ATOM   1193 C CB  . VAL A 1 170 ? 94.304  90.368  129.255 1.00 28.94 ? 163 VAL H CB  1 
ATOM   1194 C CG1 . VAL A 1 170 ? 93.762  90.739  127.876 1.00 28.86 ? 163 VAL H CG1 1 
ATOM   1195 C CG2 . VAL A 1 170 ? 95.715  90.945  129.412 1.00 28.62 ? 163 VAL H CG2 1 
ATOM   1196 N N   . HIS A 1 171 ? 91.047  91.197  129.665 1.00 28.42 ? 164 HIS H N   1 
ATOM   1197 C CA  . HIS A 1 171 ? 89.751  90.765  129.144 1.00 25.63 ? 164 HIS H CA  1 
ATOM   1198 C C   . HIS A 1 171 ? 89.569  91.331  127.758 1.00 23.86 ? 164 HIS H C   1 
ATOM   1199 O O   . HIS A 1 171 ? 89.573  92.554  127.573 1.00 22.49 ? 164 HIS H O   1 
ATOM   1200 C CB  . HIS A 1 171 ? 88.598  91.250  129.995 1.00 26.25 ? 164 HIS H CB  1 
ATOM   1201 C CG  . HIS A 1 171 ? 88.626  90.770  131.408 1.00 28.22 ? 164 HIS H CG  1 
ATOM   1202 N ND1 . HIS A 1 171 ? 88.532  89.440  131.756 1.00 29.13 ? 164 HIS H ND1 1 
ATOM   1203 C CD2 . HIS A 1 171 ? 88.688  91.459  132.568 1.00 29.20 ? 164 HIS H CD2 1 
ATOM   1204 C CE1 . HIS A 1 171 ? 88.554  89.331  133.073 1.00 29.13 ? 164 HIS H CE1 1 
ATOM   1205 N NE2 . HIS A 1 171 ? 88.642  90.543  133.589 1.00 29.58 ? 164 HIS H NE2 1 
ATOM   1206 N N   . THR A 1 172 ? 89.393  90.433  126.790 1.00 21.67 ? 165 THR H N   1 
ATOM   1207 C CA  . THR A 1 172 ? 89.104  90.793  125.400 1.00 20.33 ? 165 THR H CA  1 
ATOM   1208 C C   . THR A 1 172 ? 87.644  90.419  125.100 1.00 20.37 ? 165 THR H C   1 
ATOM   1209 O O   . THR A 1 172 ? 87.304  89.253  124.964 1.00 20.25 ? 165 THR H O   1 
ATOM   1210 C CB  . THR A 1 172 ? 90.085  90.113  124.452 1.00 19.98 ? 165 THR H CB  1 
ATOM   1211 O OG1 . THR A 1 172 ? 91.386  90.626  124.722 1.00 19.44 ? 165 THR H OG1 1 
ATOM   1212 C CG2 . THR A 1 172 ? 89.751  90.381  122.965 1.00 20.57 ? 165 THR H CG2 1 
ATOM   1213 N N   . PHE A 1 173 ? 86.797  91.438  125.002 1.00 18.57 ? 166 PHE H N   1 
ATOM   1214 C CA  . PHE A 1 173 ? 85.364  91.254  124.965 1.00 18.13 ? 166 PHE H CA  1 
ATOM   1215 C C   . PHE A 1 173 ? 84.938  90.727  123.613 1.00 18.26 ? 166 PHE H C   1 
ATOM   1216 O O   . PHE A 1 173 ? 85.643  90.938  122.617 1.00 18.57 ? 166 PHE H O   1 
ATOM   1217 C CB  . PHE A 1 173 ? 84.651  92.582  125.295 1.00 17.31 ? 166 PHE H CB  1 
ATOM   1218 C CG  . PHE A 1 173 ? 84.815  92.984  126.720 1.00 17.16 ? 166 PHE H CG  1 
ATOM   1219 C CD1 . PHE A 1 173 ? 83.950  92.504  127.696 1.00 17.21 ? 166 PHE H CD1 1 
ATOM   1220 C CD2 . PHE A 1 173 ? 85.883  93.768  127.111 1.00 17.81 ? 166 PHE H CD2 1 
ATOM   1221 C CE1 . PHE A 1 173 ? 84.120  92.844  129.017 1.00 17.07 ? 166 PHE H CE1 1 
ATOM   1222 C CE2 . PHE A 1 173 ? 86.072  94.102  128.445 1.00 17.62 ? 166 PHE H CE2 1 
ATOM   1223 C CZ  . PHE A 1 173 ? 85.189  93.642  129.404 1.00 17.64 ? 166 PHE H CZ  1 
ATOM   1224 N N   . PRO A 1 174 ? 83.786  90.035  123.564 1.00 18.06 ? 167 PRO H N   1 
ATOM   1225 C CA  . PRO A 1 174 ? 83.251  89.716  122.240 1.00 18.60 ? 167 PRO H CA  1 
ATOM   1226 C C   . PRO A 1 174 ? 82.961  90.973  121.403 1.00 18.85 ? 167 PRO H C   1 
ATOM   1227 O O   . PRO A 1 174 ? 82.525  91.991  121.925 1.00 18.12 ? 167 PRO H O   1 
ATOM   1228 C CB  . PRO A 1 174 ? 81.947  88.963  122.555 1.00 18.85 ? 167 PRO H CB  1 
ATOM   1229 C CG  . PRO A 1 174 ? 82.154  88.422  123.945 1.00 18.60 ? 167 PRO H CG  1 
ATOM   1230 C CD  . PRO A 1 174 ? 83.006  89.421  124.651 1.00 17.82 ? 167 PRO H CD  1 
ATOM   1231 N N   . ALA A 1 175 ? 83.182  90.868  120.107 1.00 19.81 ? 168 ALA H N   1 
ATOM   1232 C CA  . ALA A 1 175 ? 82.854  91.924  119.168 1.00 20.59 ? 168 ALA H CA  1 
ATOM   1233 C C   . ALA A 1 175 ? 81.362  92.182  119.194 1.00 21.72 ? 168 ALA H C   1 
ATOM   1234 O O   . ALA A 1 175 ? 80.591  91.242  119.441 1.00 22.46 ? 168 ALA H O   1 
ATOM   1235 C CB  . ALA A 1 175 ? 83.272  91.495  117.767 1.00 20.73 ? 168 ALA H CB  1 
ATOM   1236 N N   . VAL A 1 176 ? 80.956  93.439  118.966 1.00 21.62 ? 169 VAL H N   1 
ATOM   1237 C CA  . VAL A 1 176 ? 79.559  93.754  118.646 1.00 22.90 ? 169 VAL H CA  1 
ATOM   1238 C C   . VAL A 1 176 ? 79.461  94.209  117.201 1.00 24.62 ? 169 VAL H C   1 
ATOM   1239 O O   . VAL A 1 176 ? 80.373  94.881  116.694 1.00 24.96 ? 169 VAL H O   1 
ATOM   1240 C CB  . VAL A 1 176 ? 78.894  94.802  119.580 1.00 23.95 ? 169 VAL H CB  1 
ATOM   1241 C CG1 . VAL A 1 176 ? 78.810  94.259  121.005 1.00 24.10 ? 169 VAL H CG1 1 
ATOM   1242 C CG2 . VAL A 1 176 ? 79.595  96.161  119.553 1.00 23.61 ? 169 VAL H CG2 1 
ATOM   1243 N N   . LEU A 1 177 ? 78.361  93.832  116.548 1.00 25.22 ? 170 LEU H N   1 
ATOM   1244 C CA  . LEU A 1 177 ? 78.048  94.305  115.211 1.00 26.39 ? 170 LEU H CA  1 
ATOM   1245 C C   . LEU A 1 177 ? 77.337  95.661  115.310 1.00 25.92 ? 170 LEU H C   1 
ATOM   1246 O O   . LEU A 1 177 ? 76.230  95.752  115.847 1.00 25.58 ? 170 LEU H O   1 
ATOM   1247 C CB  . LEU A 1 177 ? 77.195  93.278  114.460 1.00 27.18 ? 170 LEU H CB  1 
ATOM   1248 C CG  . LEU A 1 177 ? 76.841  93.615  113.005 1.00 27.66 ? 170 LEU H CG  1 
ATOM   1249 C CD1 . LEU A 1 177 ? 78.083  93.827  112.149 1.00 27.80 ? 170 LEU H CD1 1 
ATOM   1250 C CD2 . LEU A 1 177 ? 75.970  92.503  112.428 1.00 28.06 ? 170 LEU H CD2 1 
ATOM   1251 N N   . GLN A 1 178 ? 77.994  96.715  114.817 1.00 26.82 ? 171 GLN H N   1 
ATOM   1252 C CA  . GLN A 1 178 ? 77.420  98.072  114.816 1.00 26.90 ? 171 GLN H CA  1 
ATOM   1253 C C   . GLN A 1 178 ? 76.414  98.202  113.677 1.00 28.26 ? 171 GLN H C   1 
ATOM   1254 O O   . GLN A 1 178 ? 76.507  97.475  112.686 1.00 28.14 ? 171 GLN H O   1 
ATOM   1255 C CB  . GLN A 1 178 ? 78.504  99.133  114.652 1.00 26.62 ? 171 GLN H CB  1 
ATOM   1256 C CG  . GLN A 1 178 ? 79.606  99.115  115.707 1.00 25.98 ? 171 GLN H CG  1 
ATOM   1257 C CD  . GLN A 1 178 ? 80.817  99.912  115.279 1.00 25.81 ? 171 GLN H CD  1 
ATOM   1258 O OE1 . GLN A 1 178 ? 81.185  100.902 115.918 1.00 26.74 ? 171 GLN H OE1 1 
ATOM   1259 N NE2 . GLN A 1 178 ? 81.437  99.503  114.176 1.00 25.38 ? 171 GLN H NE2 1 
ATOM   1260 N N   . SER A 1 179 ? 75.464  99.134  113.809 1.00 29.30 ? 172 SER H N   1 
ATOM   1261 C CA  . SER A 1 179 ? 74.438  99.351  112.771 1.00 30.90 ? 172 SER H CA  1 
ATOM   1262 C C   . SER A 1 179 ? 75.026  99.688  111.402 1.00 30.81 ? 172 SER H C   1 
ATOM   1263 O O   . SER A 1 179 ? 74.403  99.428  110.378 1.00 34.33 ? 172 SER H O   1 
ATOM   1264 C CB  . SER A 1 179 ? 73.429  100.418 113.200 1.00 32.59 ? 172 SER H CB  1 
ATOM   1265 O OG  . SER A 1 179 ? 74.071  101.472 113.893 1.00 36.26 ? 172 SER H OG  1 
ATOM   1266 N N   . SER A 1 180 ? 76.235  100.235 111.393 1.00 30.68 ? 173 SER H N   1 
ATOM   1267 C CA  . SER A 1 180 ? 77.034  100.384 110.171 1.00 30.59 ? 173 SER H CA  1 
ATOM   1268 C C   . SER A 1 180 ? 77.398  99.095  109.418 1.00 29.66 ? 173 SER H C   1 
ATOM   1269 O O   . SER A 1 180 ? 77.884  99.183  108.283 1.00 27.27 ? 173 SER H O   1 
ATOM   1270 C CB  . SER A 1 180 ? 78.349  101.074 110.507 1.00 31.98 ? 173 SER H CB  1 
ATOM   1271 O OG  . SER A 1 180 ? 79.193  100.197 111.254 1.00 33.55 ? 173 SER H OG  1 
ATOM   1272 N N   . GLY A 1 181 ? 77.226  97.928  110.055 1.00 27.73 ? 174 GLY H N   1 
ATOM   1273 C CA  . GLY A 1 181 ? 77.588  96.635  109.448 1.00 26.54 ? 174 GLY H CA  1 
ATOM   1274 C C   . GLY A 1 181 ? 79.046  96.264  109.667 1.00 25.60 ? 174 GLY H C   1 
ATOM   1275 O O   . GLY A 1 181 ? 79.562  95.308  109.083 1.00 25.51 ? 174 GLY H O   1 
ATOM   1276 N N   . LEU A 1 182 ? 79.714  97.030  110.518 1.00 24.48 ? 175 LEU H N   1 
ATOM   1277 C CA  . LEU A 1 182 ? 81.086  96.782  110.869 1.00 23.70 ? 175 LEU H CA  1 
ATOM   1278 C C   . LEU A 1 182 ? 81.148  96.429  112.352 1.00 22.75 ? 175 LEU H C   1 
ATOM   1279 O O   . LEU A 1 182 ? 80.295  96.843  113.167 1.00 19.91 ? 175 LEU H O   1 
ATOM   1280 C CB  . LEU A 1 182 ? 81.940  98.029  110.597 1.00 24.71 ? 175 LEU H CB  1 
ATOM   1281 C CG  . LEU A 1 182 ? 82.002  98.542  109.158 1.00 25.05 ? 175 LEU H CG  1 
ATOM   1282 C CD1 . LEU A 1 182 ? 82.771  99.856  109.091 1.00 25.27 ? 175 LEU H CD1 1 
ATOM   1283 C CD2 . LEU A 1 182 ? 82.649  97.515  108.245 1.00 24.45 ? 175 LEU H CD2 1 
ATOM   1284 N N   . TYR A 1 183 ? 82.196  95.696  112.705 1.00 21.32 ? 176 TYR H N   1 
ATOM   1285 C CA  . TYR A 1 183 ? 82.384  95.274  114.085 1.00 20.35 ? 176 TYR H CA  1 
ATOM   1286 C C   . TYR A 1 183 ? 83.214  96.243  114.906 1.00 20.69 ? 176 TYR H C   1 
ATOM   1287 O O   . TYR A 1 183 ? 83.986  97.051  114.375 1.00 20.64 ? 176 TYR H O   1 
ATOM   1288 C CB  . TYR A 1 183 ? 83.036  93.898  114.117 1.00 20.15 ? 176 TYR H CB  1 
ATOM   1289 C CG  . TYR A 1 183 ? 82.185  92.822  113.503 1.00 19.86 ? 176 TYR H CG  1 
ATOM   1290 C CD1 . TYR A 1 183 ? 81.209  92.182  114.245 1.00 19.44 ? 176 TYR H CD1 1 
ATOM   1291 C CD2 . TYR A 1 183 ? 82.350  92.453  112.167 1.00 20.61 ? 176 TYR H CD2 1 
ATOM   1292 C CE1 . TYR A 1 183 ? 80.427  91.187  113.693 1.00 20.17 ? 176 TYR H CE1 1 
ATOM   1293 C CE2 . TYR A 1 183 ? 81.566  91.464  111.598 1.00 21.23 ? 176 TYR H CE2 1 
ATOM   1294 C CZ  . TYR A 1 183 ? 80.610  90.822  112.372 1.00 20.94 ? 176 TYR H CZ  1 
ATOM   1295 O OH  . TYR A 1 183 ? 79.838  89.826  111.813 1.00 22.90 ? 176 TYR H OH  1 
ATOM   1296 N N   . SER A 1 184 ? 83.044  96.141  116.217 1.00 21.16 ? 177 SER H N   1 
ATOM   1297 C CA  . SER A 1 184 ? 83.859  96.868  117.179 1.00 21.78 ? 177 SER H CA  1 
ATOM   1298 C C   . SER A 1 184 ? 84.064  96.046  118.446 1.00 22.18 ? 177 SER H C   1 
ATOM   1299 O O   . SER A 1 184 ? 83.150  95.357  118.904 1.00 20.54 ? 177 SER H O   1 
ATOM   1300 C CB  . SER A 1 184 ? 83.174  98.168  117.563 1.00 22.31 ? 177 SER H CB  1 
ATOM   1301 O OG  . SER A 1 184 ? 83.977  98.874  118.490 1.00 22.77 ? 177 SER H OG  1 
ATOM   1302 N N   . LEU A 1 185 ? 85.267  96.120  119.008 1.00 23.67 ? 178 LEU H N   1 
ATOM   1303 C CA  . LEU A 1 185 ? 85.528  95.531  120.329 1.00 24.61 ? 178 LEU H CA  1 
ATOM   1304 C C   . LEU A 1 185 ? 86.560  96.247  121.164 1.00 23.11 ? 178 LEU H C   1 
ATOM   1305 O O   . LEU A 1 185 ? 87.390  97.015  120.676 1.00 22.68 ? 178 LEU H O   1 
ATOM   1306 C CB  . LEU A 1 185 ? 85.907  94.048  120.242 1.00 25.49 ? 178 LEU H CB  1 
ATOM   1307 C CG  . LEU A 1 185 ? 87.180  93.551  119.556 1.00 27.76 ? 178 LEU H CG  1 
ATOM   1308 C CD1 . LEU A 1 185 ? 88.480  93.747  120.343 1.00 28.86 ? 178 LEU H CD1 1 
ATOM   1309 C CD2 . LEU A 1 185 ? 87.016  92.058  119.308 1.00 29.38 ? 178 LEU H CD2 1 
ATOM   1310 N N   . SER A 1 186 ? 86.473  95.960  122.446 1.00 22.78 ? 179 SER H N   1 
ATOM   1311 C CA  . SER A 1 186 ? 87.448  96.396  123.412 1.00 24.62 ? 179 SER H CA  1 
ATOM   1312 C C   . SER A 1 186 ? 88.275  95.239  123.974 1.00 23.99 ? 179 SER H C   1 
ATOM   1313 O O   . SER A 1 186 ? 87.774  94.124  124.150 1.00 23.76 ? 179 SER H O   1 
ATOM   1314 C CB  . SER A 1 186 ? 86.737  97.136  124.525 1.00 25.11 ? 179 SER H CB  1 
ATOM   1315 O OG  . SER A 1 186 ? 86.701  98.502  124.157 1.00 29.69 ? 179 SER H OG  1 
ATOM   1316 N N   . SER A 1 187 ? 89.549  95.524  124.213 1.00 23.83 ? 180 SER H N   1 
ATOM   1317 C CA  . SER A 1 187 ? 90.409  94.682  125.032 1.00 24.28 ? 180 SER H CA  1 
ATOM   1318 C C   . SER A 1 187 ? 90.951  95.569  126.119 1.00 23.91 ? 180 SER H C   1 
ATOM   1319 O O   . SER A 1 187 ? 91.492  96.624  125.844 1.00 24.06 ? 180 SER H O   1 
ATOM   1320 C CB  . SER A 1 187 ? 91.559  94.084  124.236 1.00 24.79 ? 180 SER H CB  1 
ATOM   1321 O OG  . SER A 1 187 ? 92.305  93.189  125.048 1.00 25.25 ? 180 SER H OG  1 
ATOM   1322 N N   . VAL A 1 188 ? 90.760  95.151  127.355 1.00 24.33 ? 181 VAL H N   1 
ATOM   1323 C CA  . VAL A 1 188 ? 91.232  95.899  128.499 1.00 24.68 ? 181 VAL H CA  1 
ATOM   1324 C C   . VAL A 1 188 ? 92.233  95.054  129.288 1.00 26.28 ? 181 VAL H C   1 
ATOM   1325 O O   . VAL A 1 188 ? 92.275  93.828  129.144 1.00 24.77 ? 181 VAL H O   1 
ATOM   1326 C CB  . VAL A 1 188 ? 90.072  96.344  129.415 1.00 23.74 ? 181 VAL H CB  1 
ATOM   1327 C CG1 . VAL A 1 188 ? 89.043  97.124  128.609 1.00 24.03 ? 181 VAL H CG1 1 
ATOM   1328 C CG2 . VAL A 1 188 ? 89.413  95.171  130.131 1.00 23.50 ? 181 VAL H CG2 1 
ATOM   1329 N N   . VAL A 1 189 ? 93.025  95.738  130.111 1.00 28.10 ? 182 VAL H N   1 
ATOM   1330 C CA  . VAL A 1 189 ? 93.782  95.119  131.200 1.00 29.62 ? 182 VAL H CA  1 
ATOM   1331 C C   . VAL A 1 189 ? 93.824  96.030  132.435 1.00 31.53 ? 182 VAL H C   1 
ATOM   1332 O O   . VAL A 1 189 ? 93.888  97.259  132.321 1.00 32.28 ? 182 VAL H O   1 
ATOM   1333 C CB  . VAL A 1 189 ? 95.215  94.730  130.765 1.00 30.83 ? 182 VAL H CB  1 
ATOM   1334 C CG1 . VAL A 1 189 ? 95.996  95.936  130.240 1.00 30.90 ? 182 VAL H CG1 1 
ATOM   1335 C CG2 . VAL A 1 189 ? 95.956  94.028  131.905 1.00 30.38 ? 182 VAL H CG2 1 
ATOM   1336 N N   . THR A 1 190 ? 93.763  95.403  133.610 1.00 33.49 ? 183 THR H N   1 
ATOM   1337 C CA  . THR A 1 190 ? 93.982  96.077  134.887 1.00 34.26 ? 183 THR H CA  1 
ATOM   1338 C C   . THR A 1 190 ? 95.408  95.807  135.328 1.00 33.42 ? 183 THR H C   1 
ATOM   1339 O O   . THR A 1 190 ? 95.858  94.678  135.318 1.00 32.21 ? 183 THR H O   1 
ATOM   1340 C CB  . THR A 1 190 ? 92.999  95.636  135.994 1.00 34.51 ? 183 THR H CB  1 
ATOM   1341 O OG1 . THR A 1 190 ? 92.929  94.209  136.064 1.00 34.91 ? 183 THR H OG1 1 
ATOM   1342 C CG2 . THR A 1 190 ? 91.615  96.196  135.727 1.00 35.76 ? 183 THR H CG2 1 
ATOM   1343 N N   . VAL A 1 191 ? 96.118  96.871  135.672 1.00 36.81 ? 184 VAL H N   1 
ATOM   1344 C CA  . VAL A 1 191 ? 97.525  96.793  136.076 1.00 37.16 ? 184 VAL H CA  1 
ATOM   1345 C C   . VAL A 1 191 ? 97.670  97.534  137.415 1.00 40.13 ? 184 VAL H C   1 
ATOM   1346 O O   . VAL A 1 191 ? 96.761  98.283  137.819 1.00 35.79 ? 184 VAL H O   1 
ATOM   1347 C CB  . VAL A 1 191 ? 98.457  97.397  135.007 1.00 36.40 ? 184 VAL H CB  1 
ATOM   1348 C CG1 . VAL A 1 191 ? 98.226  96.731  133.657 1.00 36.96 ? 184 VAL H CG1 1 
ATOM   1349 C CG2 . VAL A 1 191 ? 98.266  98.905  134.898 1.00 36.81 ? 184 VAL H CG2 1 
ATOM   1350 N N   . PRO A 1 192 ? 98.803  97.329  138.117 1.00 43.06 ? 185 PRO H N   1 
ATOM   1351 C CA  . PRO A 1 192 ? 98.971  98.101  139.347 1.00 45.23 ? 185 PRO H CA  1 
ATOM   1352 C C   . PRO A 1 192 ? 99.146  99.583  139.019 1.00 43.54 ? 185 PRO H C   1 
ATOM   1353 O O   . PRO A 1 192 ? 99.805  99.921  138.037 1.00 43.28 ? 185 PRO H O   1 
ATOM   1354 C CB  . PRO A 1 192 ? 100.239 97.495  139.991 1.00 46.30 ? 185 PRO H CB  1 
ATOM   1355 C CG  . PRO A 1 192 ? 100.570 96.272  139.189 1.00 45.74 ? 185 PRO H CG  1 
ATOM   1356 C CD  . PRO A 1 192 ? 99.991  96.506  137.828 1.00 45.14 ? 185 PRO H CD  1 
ATOM   1357 N N   . SER A 1 193 ? 98.518  100.438 139.819 1.00 45.64 ? 186 SER H N   1 
ATOM   1358 C CA  . SER A 1 193 ? 98.507  101.890 139.599 1.00 48.56 ? 186 SER H CA  1 
ATOM   1359 C C   . SER A 1 193 ? 99.919  102.479 139.438 1.00 51.90 ? 186 SER H C   1 
ATOM   1360 O O   . SER A 1 193 ? 100.182 103.263 138.515 1.00 53.13 ? 186 SER H O   1 
ATOM   1361 C CB  . SER A 1 193 ? 97.782  102.571 140.763 1.00 49.90 ? 186 SER H CB  1 
ATOM   1362 O OG  . SER A 1 193 ? 97.535  103.938 140.492 1.00 52.27 ? 186 SER H OG  1 
ATOM   1363 N N   . SER A 1 194 ? 100.829 102.043 140.308 1.00 52.81 ? 187 SER H N   1 
ATOM   1364 C CA  . SER A 1 194 ? 102.198 102.582 140.387 1.00 54.55 ? 187 SER H CA  1 
ATOM   1365 C C   . SER A 1 194 ? 103.158 102.260 139.218 1.00 55.36 ? 187 SER H C   1 
ATOM   1366 O O   . SER A 1 194 ? 104.267 102.784 139.185 1.00 54.21 ? 187 SER H O   1 
ATOM   1367 C CB  . SER A 1 194 ? 102.827 102.145 141.717 1.00 54.35 ? 187 SER H CB  1 
ATOM   1368 O OG  . SER A 1 194 ? 102.584 100.772 141.976 1.00 52.64 ? 187 SER H OG  1 
ATOM   1369 N N   . SER A 1 195 ? 102.744 101.417 138.270 1.00 56.42 ? 188 SER H N   1 
ATOM   1370 C CA  . SER A 1 195 ? 103.576 101.097 137.103 1.00 55.00 ? 188 SER H CA  1 
ATOM   1371 C C   . SER A 1 195 ? 103.422 102.090 135.943 1.00 55.29 ? 188 SER H C   1 
ATOM   1372 O O   . SER A 1 195 ? 104.186 102.028 134.989 1.00 57.34 ? 188 SER H O   1 
ATOM   1373 C CB  . SER A 1 195 ? 103.295 99.663  136.620 1.00 55.10 ? 188 SER H CB  1 
ATOM   1374 O OG  . SER A 1 195 ? 101.912 99.428  136.403 1.00 55.87 ? 188 SER H OG  1 
ATOM   1375 N N   . LEU A 1 196 ? 102.462 103.009 136.027 1.00 56.67 ? 189 LEU H N   1 
ATOM   1376 C CA  . LEU A 1 196 ? 102.119 103.878 134.896 1.00 56.53 ? 189 LEU H CA  1 
ATOM   1377 C C   . LEU A 1 196 ? 103.181 104.957 134.681 1.00 58.01 ? 189 LEU H C   1 
ATOM   1378 O O   . LEU A 1 196 ? 103.391 105.802 135.551 1.00 58.64 ? 189 LEU H O   1 
ATOM   1379 C CB  . LEU A 1 196 ? 100.758 104.531 135.133 1.00 55.85 ? 189 LEU H CB  1 
ATOM   1380 C CG  . LEU A 1 196 ? 99.570  103.577 135.311 1.00 55.68 ? 189 LEU H CG  1 
ATOM   1381 C CD1 . LEU A 1 196 ? 98.373  104.308 135.899 1.00 55.51 ? 189 LEU H CD1 1 
ATOM   1382 C CD2 . LEU A 1 196 ? 99.198  102.924 133.992 1.00 55.07 ? 189 LEU H CD2 1 
ATOM   1383 N N   . GLY A 1 197 ? 103.854 104.908 133.530 1.00 59.33 ? 190 GLY H N   1 
ATOM   1384 C CA  . GLY A 1 197 ? 105.014 105.775 133.248 1.00 61.64 ? 190 GLY H CA  1 
ATOM   1385 C C   . GLY A 1 197 ? 106.359 105.088 133.466 1.00 61.57 ? 190 GLY H C   1 
ATOM   1386 O O   . GLY A 1 197 ? 107.367 105.501 132.886 1.00 62.80 ? 190 GLY H O   1 
ATOM   1387 N N   . THR A 1 198 ? 106.373 104.068 134.329 1.00 61.10 ? 191 THR H N   1 
ATOM   1388 C CA  . THR A 1 198 ? 107.487 103.117 134.466 1.00 60.40 ? 191 THR H CA  1 
ATOM   1389 C C   . THR A 1 198 ? 107.413 102.027 133.391 1.00 57.88 ? 191 THR H C   1 
ATOM   1390 O O   . THR A 1 198 ? 108.401 101.700 132.735 1.00 61.56 ? 191 THR H O   1 
ATOM   1391 C CB  . THR A 1 198 ? 107.418 102.399 135.833 1.00 61.18 ? 191 THR H CB  1 
ATOM   1392 O OG1 . THR A 1 198 ? 107.279 103.365 136.880 1.00 66.61 ? 191 THR H OG1 1 
ATOM   1393 C CG2 . THR A 1 198 ? 108.666 101.530 136.082 1.00 60.52 ? 191 THR H CG2 1 
ATOM   1394 N N   . GLN A 1 199 ? 106.219 101.460 133.260 1.00 53.71 ? 192 GLN H N   1 
ATOM   1395 C CA  . GLN A 1 199 ? 105.932 100.304 132.415 1.00 48.15 ? 192 GLN H CA  1 
ATOM   1396 C C   . GLN A 1 199 ? 105.225 100.750 131.135 1.00 43.06 ? 192 GLN H C   1 
ATOM   1397 O O   . GLN A 1 199 ? 104.255 101.512 131.203 1.00 45.62 ? 192 GLN H O   1 
ATOM   1398 C CB  . GLN A 1 199 ? 105.029 99.354  133.224 1.00 49.07 ? 192 GLN H CB  1 
ATOM   1399 C CG  . GLN A 1 199 ? 104.616 98.066  132.533 1.00 49.56 ? 192 GLN H CG  1 
ATOM   1400 C CD  . GLN A 1 199 ? 105.811 97.249  132.095 1.00 49.64 ? 192 GLN H CD  1 
ATOM   1401 O OE1 . GLN A 1 199 ? 106.588 96.801  132.933 1.00 51.91 ? 192 GLN H OE1 1 
ATOM   1402 N NE2 . GLN A 1 199 ? 105.976 97.063  130.785 1.00 48.53 ? 192 GLN H NE2 1 
ATOM   1403 N N   . THR A 1 200 ? 105.708 100.301 129.978 1.00 37.17 ? 193 THR H N   1 
ATOM   1404 C CA  . THR A 1 200 ? 105.005 100.551 128.728 1.00 34.66 ? 193 THR H CA  1 
ATOM   1405 C C   . THR A 1 200 ? 103.982 99.433  128.511 1.00 33.92 ? 193 THR H C   1 
ATOM   1406 O O   . THR A 1 200 ? 104.222 98.273  128.871 1.00 31.90 ? 193 THR H O   1 
ATOM   1407 C CB  . THR A 1 200 ? 105.914 100.686 127.481 1.00 34.05 ? 193 THR H CB  1 
ATOM   1408 O OG1 . THR A 1 200 ? 106.427 99.412  127.105 1.00 40.33 ? 193 THR H OG1 1 
ATOM   1409 C CG2 . THR A 1 200 ? 107.072 101.622 127.718 1.00 34.53 ? 193 THR H CG2 1 
ATOM   1410 N N   . TYR A 1 201 ? 102.838 99.812  127.932 1.00 32.35 ? 194 TYR H N   1 
ATOM   1411 C CA  . TYR A 1 201 ? 101.774 98.891  127.564 1.00 30.19 ? 194 TYR H CA  1 
ATOM   1412 C C   . TYR A 1 201 ? 101.382 99.132  126.125 1.00 29.05 ? 194 TYR H C   1 
ATOM   1413 O O   . TYR A 1 201 ? 101.067 100.263 125.736 1.00 29.67 ? 194 TYR H O   1 
ATOM   1414 C CB  . TYR A 1 201 ? 100.549 99.098  128.438 1.00 30.59 ? 194 TYR H CB  1 
ATOM   1415 C CG  . TYR A 1 201 ? 100.805 98.878  129.891 1.00 30.16 ? 194 TYR H CG  1 
ATOM   1416 C CD1 . TYR A 1 201 ? 100.949 97.594  130.403 1.00 30.99 ? 194 TYR H CD1 1 
ATOM   1417 C CD2 . TYR A 1 201 ? 100.906 99.955  130.766 1.00 29.67 ? 194 TYR H CD2 1 
ATOM   1418 C CE1 . TYR A 1 201 ? 101.192 97.387  131.757 1.00 30.67 ? 194 TYR H CE1 1 
ATOM   1419 C CE2 . TYR A 1 201 ? 101.141 99.763  132.112 1.00 29.88 ? 194 TYR H CE2 1 
ATOM   1420 C CZ  . TYR A 1 201 ? 101.278 98.476  132.610 1.00 31.15 ? 194 TYR H CZ  1 
ATOM   1421 O OH  . TYR A 1 201 ? 101.504 98.289  133.966 1.00 33.34 ? 194 TYR H OH  1 
ATOM   1422 N N   . ILE A 1 202 ? 101.374 98.051  125.362 1.00 27.94 ? 195 ILE H N   1 
ATOM   1423 C CA  . ILE A 1 202 ? 101.111 98.054  123.942 1.00 28.17 ? 195 ILE H CA  1 
ATOM   1424 C C   . ILE A 1 202 ? 100.121 96.907  123.685 1.00 29.13 ? 195 ILE H C   1 
ATOM   1425 O O   . ILE A 1 202 ? 100.381 95.754  124.091 1.00 29.23 ? 195 ILE H O   1 
ATOM   1426 C CB  . ILE A 1 202 ? 102.408 97.790  123.149 1.00 28.83 ? 195 ILE H CB  1 
ATOM   1427 C CG1 . ILE A 1 202 ? 103.414 98.941  123.332 1.00 30.66 ? 195 ILE H CG1 1 
ATOM   1428 C CG2 . ILE A 1 202 ? 102.126 97.623  121.671 1.00 28.94 ? 195 ILE H CG2 1 
ATOM   1429 C CD1 . ILE A 1 202 ? 104.857 98.505  123.273 1.00 30.72 ? 195 ILE H CD1 1 
ATOM   1430 N N   . CYS A 1 203 ? 99.001  97.229  123.032 1.00 26.95 ? 196 CYS H N   1 
ATOM   1431 C CA  . CYS A 1 203 ? 98.103  96.216  122.479 1.00 26.46 ? 196 CYS H CA  1 
ATOM   1432 C C   . CYS A 1 203 ? 98.578  95.851  121.074 1.00 25.35 ? 196 CYS H C   1 
ATOM   1433 O O   . CYS A 1 203 ? 98.817  96.727  120.243 1.00 22.44 ? 196 CYS H O   1 
ATOM   1434 C CB  . CYS A 1 203 ? 96.642  96.674  122.465 1.00 26.56 ? 196 CYS H CB  1 
ATOM   1435 S SG  . CYS A 1 203 ? 96.244  98.061  121.396 1.00 30.02 ? 196 CYS H SG  1 
ATOM   1436 N N   . ASN A 1 204 ? 98.750  94.548  120.853 1.00 24.73 ? 197 ASN H N   1 
ATOM   1437 C CA  . ASN A 1 204 ? 99.128  93.999  119.568 1.00 25.63 ? 197 ASN H CA  1 
ATOM   1438 C C   . ASN A 1 204 ? 97.861  93.501  118.935 1.00 26.01 ? 197 ASN H C   1 
ATOM   1439 O O   . ASN A 1 204 ? 97.280  92.530  119.411 1.00 26.17 ? 197 ASN H O   1 
ATOM   1440 C CB  . ASN A 1 204 ? 100.118 92.837  119.734 1.00 26.10 ? 197 ASN H CB  1 
ATOM   1441 C CG  . ASN A 1 204 ? 101.155 93.129  120.777 1.00 26.52 ? 197 ASN H CG  1 
ATOM   1442 O OD1 . ASN A 1 204 ? 101.065 92.656  121.911 1.00 25.65 ? 197 ASN H OD1 1 
ATOM   1443 N ND2 . ASN A 1 204 ? 102.106 93.991  120.429 1.00 27.61 ? 197 ASN H ND2 1 
ATOM   1444 N N   . VAL A 1 205 ? 97.456  94.170  117.858 1.00 27.09 ? 198 VAL H N   1 
ATOM   1445 C CA  . VAL A 1 205 ? 96.190  93.937  117.180 1.00 27.22 ? 198 VAL H CA  1 
ATOM   1446 C C   . VAL A 1 205 ? 96.481  93.332  115.816 1.00 27.15 ? 198 VAL H C   1 
ATOM   1447 O O   . VAL A 1 205 ? 97.394  93.772  115.125 1.00 27.90 ? 198 VAL H O   1 
ATOM   1448 C CB  . VAL A 1 205 ? 95.400  95.252  117.002 1.00 26.90 ? 198 VAL H CB  1 
ATOM   1449 C CG1 . VAL A 1 205 ? 94.111  95.025  116.220 1.00 27.35 ? 198 VAL H CG1 1 
ATOM   1450 C CG2 . VAL A 1 205 ? 95.080  95.872  118.357 1.00 27.66 ? 198 VAL H CG2 1 
ATOM   1451 N N   . ASN A 1 206 ? 95.670  92.349  115.427 1.00 26.22 ? 199 ASN H N   1 
ATOM   1452 C CA  . ASN A 1 206 ? 95.807  91.694  114.147 1.00 26.12 ? 199 ASN H CA  1 
ATOM   1453 C C   . ASN A 1 206 ? 94.449  91.349  113.547 1.00 26.72 ? 199 ASN H C   1 
ATOM   1454 O O   . ASN A 1 206 ? 93.639  90.672  114.173 1.00 25.29 ? 199 ASN H O   1 
ATOM   1455 C CB  . ASN A 1 206 ? 96.646  90.432  114.327 1.00 27.26 ? 199 ASN H CB  1 
ATOM   1456 C CG  . ASN A 1 206 ? 97.167  89.887  113.027 1.00 28.51 ? 199 ASN H CG  1 
ATOM   1457 O OD1 . ASN A 1 206 ? 96.722  90.272  111.949 1.00 28.33 ? 199 ASN H OD1 1 
ATOM   1458 N ND2 . ASN A 1 206 ? 98.130  88.973  113.124 1.00 29.93 ? 199 ASN H ND2 1 
ATOM   1459 N N   . HIS A 1 207 ? 94.230  91.832  112.326 1.00 26.89 ? 200 HIS H N   1 
ATOM   1460 C CA  . HIS A 1 207 ? 93.064  91.535  111.535 1.00 28.01 ? 200 HIS H CA  1 
ATOM   1461 C C   . HIS A 1 207 ? 93.485  90.890  110.214 1.00 30.31 ? 200 HIS H C   1 
ATOM   1462 O O   . HIS A 1 207 ? 93.714  91.577  109.200 1.00 28.42 ? 200 HIS H O   1 
ATOM   1463 C CB  . HIS A 1 207 ? 92.259  92.802  111.260 1.00 27.25 ? 200 HIS H CB  1 
ATOM   1464 C CG  . HIS A 1 207 ? 90.956  92.533  110.580 1.00 26.70 ? 200 HIS H CG  1 
ATOM   1465 N ND1 . HIS A 1 207 ? 90.686  92.957  109.298 1.00 27.01 ? 200 HIS H ND1 1 
ATOM   1466 C CD2 . HIS A 1 207 ? 89.856  91.863  110.993 1.00 26.78 ? 200 HIS H CD2 1 
ATOM   1467 C CE1 . HIS A 1 207 ? 89.473  92.570  108.952 1.00 27.53 ? 200 HIS H CE1 1 
ATOM   1468 N NE2 . HIS A 1 207 ? 88.944  91.906  109.966 1.00 26.93 ? 200 HIS H NE2 1 
ATOM   1469 N N   . LYS A 1 208 ? 93.541  89.561  110.226 1.00 33.44 ? 201 LYS H N   1 
ATOM   1470 C CA  . LYS A 1 208 ? 94.098  88.802  109.105 1.00 35.62 ? 201 LYS H CA  1 
ATOM   1471 C C   . LYS A 1 208 ? 93.321  88.976  107.799 1.00 35.10 ? 201 LYS H C   1 
ATOM   1472 O O   . LYS A 1 208 ? 93.933  89.010  106.742 1.00 36.64 ? 201 LYS H O   1 
ATOM   1473 C CB  . LYS A 1 208 ? 94.241  87.314  109.453 1.00 40.88 ? 201 LYS H CB  1 
ATOM   1474 C CG  . LYS A 1 208 ? 94.983  87.056  110.760 1.00 44.55 ? 201 LYS H CG  1 
ATOM   1475 C CD  . LYS A 1 208 ? 96.016  85.944  110.669 1.00 48.86 ? 201 LYS H CD  1 
ATOM   1476 C CE  . LYS A 1 208 ? 97.271  86.348  111.426 1.00 53.96 ? 201 LYS H CE  1 
ATOM   1477 N NZ  . LYS A 1 208 ? 98.401  85.394  111.271 1.00 56.45 ? 201 LYS H NZ  1 
ATOM   1478 N N   . PRO A 1 209 ? 91.980  89.108  107.855 1.00 34.01 ? 202 PRO H N   1 
ATOM   1479 C CA  . PRO A 1 209 ? 91.278  89.273  106.578 1.00 34.31 ? 202 PRO H CA  1 
ATOM   1480 C C   . PRO A 1 209 ? 91.686  90.476  105.721 1.00 34.77 ? 202 PRO H C   1 
ATOM   1481 O O   . PRO A 1 209 ? 91.583  90.403  104.505 1.00 37.22 ? 202 PRO H O   1 
ATOM   1482 C CB  . PRO A 1 209 ? 89.817  89.390  107.004 1.00 32.77 ? 202 PRO H CB  1 
ATOM   1483 C CG  . PRO A 1 209 ? 89.740  88.566  108.233 1.00 32.41 ? 202 PRO H CG  1 
ATOM   1484 C CD  . PRO A 1 209 ? 91.043  88.763  108.941 1.00 32.98 ? 202 PRO H CD  1 
ATOM   1485 N N   . SER A 1 210 ? 92.125  91.564  106.346 1.00 35.22 ? 203 SER H N   1 
ATOM   1486 C CA  . SER A 1 210 ? 92.618  92.745  105.627 1.00 35.25 ? 203 SER H CA  1 
ATOM   1487 C C   . SER A 1 210 ? 94.152  92.898  105.656 1.00 36.76 ? 203 SER H C   1 
ATOM   1488 O O   . SER A 1 210 ? 94.693  93.789  105.016 1.00 35.11 ? 203 SER H O   1 
ATOM   1489 C CB  . SER A 1 210 ? 91.973  93.991  106.216 1.00 34.02 ? 203 SER H CB  1 
ATOM   1490 O OG  . SER A 1 210 ? 92.433  94.210  107.544 1.00 33.53 ? 203 SER H OG  1 
ATOM   1491 N N   . ASN A 1 211 ? 94.828  92.015  106.390 1.00 39.77 ? 204 ASN H N   1 
ATOM   1492 C CA  . ASN A 1 211 ? 96.253  92.145  106.748 1.00 42.82 ? 204 ASN H CA  1 
ATOM   1493 C C   . ASN A 1 211 ? 96.583  93.444  107.456 1.00 40.64 ? 204 ASN H C   1 
ATOM   1494 O O   . ASN A 1 211 ? 97.539  94.149  107.100 1.00 40.65 ? 204 ASN H O   1 
ATOM   1495 C CB  . ASN A 1 211 ? 97.185  91.968  105.545 1.00 46.90 ? 204 ASN H CB  1 
ATOM   1496 C CG  . ASN A 1 211 ? 98.615  91.570  105.949 1.00 51.83 ? 204 ASN H CG  1 
ATOM   1497 O OD1 . ASN A 1 211 ? 99.028  91.676  107.121 1.00 57.04 ? 204 ASN H OD1 1 
ATOM   1498 N ND2 . ASN A 1 211 ? 99.379  91.111  104.972 1.00 52.90 ? 204 ASN H ND2 1 
ATOM   1499 N N   . THR A 1 212 ? 95.788  93.754  108.464 1.00 38.14 ? 205 THR H N   1 
ATOM   1500 C CA  . THR A 1 212 ? 96.012  94.934  109.268 1.00 36.29 ? 205 THR H CA  1 
ATOM   1501 C C   . THR A 1 212 ? 96.613  94.466  110.591 1.00 36.04 ? 205 THR H C   1 
ATOM   1502 O O   . THR A 1 212 ? 95.924  93.849  111.405 1.00 32.97 ? 205 THR H O   1 
ATOM   1503 C CB  . THR A 1 212 ? 94.709  95.710  109.463 1.00 35.17 ? 205 THR H CB  1 
ATOM   1504 O OG1 . THR A 1 212 ? 94.166  96.008  108.176 1.00 36.16 ? 205 THR H OG1 1 
ATOM   1505 C CG2 . THR A 1 212 ? 94.945  97.012  110.212 1.00 34.60 ? 205 THR H CG2 1 
ATOM   1506 N N   . LYS A 1 213 ? 97.913  94.727  110.757 1.00 35.11 ? 206 LYS H N   1 
ATOM   1507 C CA  . LYS A 1 213 ? 98.619  94.510  112.026 1.00 36.13 ? 206 LYS H CA  1 
ATOM   1508 C C   . LYS A 1 213 ? 99.101  95.837  112.584 1.00 32.69 ? 206 LYS H C   1 
ATOM   1509 O O   . LYS A 1 213 ? 99.786  96.589  111.901 1.00 30.59 ? 206 LYS H O   1 
ATOM   1510 C CB  . LYS A 1 213 ? 99.811  93.571  111.860 1.00 39.71 ? 206 LYS H CB  1 
ATOM   1511 C CG  . LYS A 1 213 ? 99.476  92.112  112.099 1.00 45.26 ? 206 LYS H CG  1 
ATOM   1512 C CD  . LYS A 1 213 ? 100.693 91.215  111.908 1.00 49.00 ? 206 LYS H CD  1 
ATOM   1513 C CE  . LYS A 1 213 ? 101.011 91.008  110.430 1.00 51.45 ? 206 LYS H CE  1 
ATOM   1514 N NZ  . LYS A 1 213 ? 102.385 90.473  110.215 1.00 51.58 ? 206 LYS H NZ  1 
ATOM   1515 N N   . VAL A 1 214 ? 98.751  96.095  113.839 1.00 30.22 ? 207 VAL H N   1 
ATOM   1516 C CA  . VAL A 1 214 ? 98.998  97.371  114.482 1.00 29.63 ? 207 VAL H CA  1 
ATOM   1517 C C   . VAL A 1 214 ? 99.431  97.093  115.909 1.00 29.22 ? 207 VAL H C   1 
ATOM   1518 O O   . VAL A 1 214 ? 98.786  96.325  116.624 1.00 27.29 ? 207 VAL H O   1 
ATOM   1519 C CB  . VAL A 1 214 ? 97.713  98.225  114.503 1.00 30.83 ? 207 VAL H CB  1 
ATOM   1520 C CG1 . VAL A 1 214 ? 97.923  99.528  115.269 1.00 30.48 ? 207 VAL H CG1 1 
ATOM   1521 C CG2 . VAL A 1 214 ? 97.229  98.494  113.079 1.00 30.42 ? 207 VAL H CG2 1 
ATOM   1522 N N   . ASP A 1 215 ? 100.535 97.706  116.317 1.00 27.76 ? 208 ASP H N   1 
ATOM   1523 C CA  . ASP A 1 215 ? 100.921 97.729  117.711 1.00 27.75 ? 208 ASP H CA  1 
ATOM   1524 C C   . ASP A 1 215 ? 100.668 99.140  118.200 1.00 27.71 ? 208 ASP H C   1 
ATOM   1525 O O   . ASP A 1 215 ? 101.200 100.105 117.631 1.00 29.39 ? 208 ASP H O   1 
ATOM   1526 C CB  . ASP A 1 215 ? 102.386 97.343  117.895 1.00 28.69 ? 208 ASP H CB  1 
ATOM   1527 C CG  . ASP A 1 215 ? 102.660 95.906  117.516 1.00 28.83 ? 208 ASP H CG  1 
ATOM   1528 O OD1 . ASP A 1 215 ? 101.842 95.024  117.860 1.00 29.95 ? 208 ASP H OD1 1 
ATOM   1529 O OD2 . ASP A 1 215 ? 103.713 95.651  116.903 1.00 29.71 ? 208 ASP H OD2 1 
ATOM   1530 N N   . LYS A 1 216 ? 99.842  99.263  119.236 1.00 26.28 ? 209 LYS H N   1 
ATOM   1531 C CA  . LYS A 1 216 ? 99.421  100.563 119.724 1.00 26.75 ? 209 LYS H CA  1 
ATOM   1532 C C   . LYS A 1 216 ? 99.828  100.712 121.163 1.00 26.17 ? 209 LYS H C   1 
ATOM   1533 O O   . LYS A 1 216 ? 99.392  99.940  122.005 1.00 24.58 ? 209 LYS H O   1 
ATOM   1534 C CB  . LYS A 1 216 ? 97.916  100.713 119.624 1.00 28.43 ? 209 LYS H CB  1 
ATOM   1535 C CG  . LYS A 1 216 ? 97.375  102.070 120.061 1.00 29.66 ? 209 LYS H CG  1 
ATOM   1536 C CD  . LYS A 1 216 ? 97.686  103.106 118.996 1.00 30.46 ? 209 LYS H CD  1 
ATOM   1537 C CE  . LYS A 1 216 ? 96.931  104.401 119.182 1.00 30.83 ? 209 LYS H CE  1 
ATOM   1538 N NZ  . LYS A 1 216 ? 97.387  105.355 118.140 1.00 31.40 ? 209 LYS H NZ  1 
ATOM   1539 N N   . LYS A 1 217 ? 100.632 101.737 121.435 1.00 25.21 ? 210 LYS H N   1 
ATOM   1540 C CA  . LYS A 1 217 ? 101.001 102.092 122.782 1.00 25.88 ? 210 LYS H CA  1 
ATOM   1541 C C   . LYS A 1 217 ? 99.865  102.844 123.459 1.00 25.42 ? 210 LYS H C   1 
ATOM   1542 O O   . LYS A 1 217 ? 99.173  103.654 122.838 1.00 24.48 ? 210 LYS H O   1 
ATOM   1543 C CB  . LYS A 1 217 ? 102.255 102.960 122.797 1.00 27.61 ? 210 LYS H CB  1 
ATOM   1544 C CG  . LYS A 1 217 ? 102.760 103.230 124.217 1.00 29.73 ? 210 LYS H CG  1 
ATOM   1545 C CD  . LYS A 1 217 ? 104.155 103.846 124.215 1.00 31.47 ? 210 LYS H CD  1 
ATOM   1546 C CE  . LYS A 1 217 ? 104.675 104.034 125.621 1.00 34.25 ? 210 LYS H CE  1 
ATOM   1547 N NZ  . LYS A 1 217 ? 105.312 105.364 125.804 1.00 38.78 ? 210 LYS H NZ  1 
ATOM   1548 N N   . VAL A 1 218 ? 99.706  102.577 124.746 1.00 25.86 ? 211 VAL H N   1 
ATOM   1549 C CA  . VAL A 1 218 ? 98.616  103.106 125.520 1.00 28.30 ? 211 VAL H CA  1 
ATOM   1550 C C   . VAL A 1 218 ? 99.242  103.753 126.738 1.00 31.84 ? 211 VAL H C   1 
ATOM   1551 O O   . VAL A 1 218 ? 99.951  103.100 127.502 1.00 32.30 ? 211 VAL H O   1 
ATOM   1552 C CB  . VAL A 1 218 ? 97.632  101.986 125.906 1.00 28.07 ? 211 VAL H CB  1 
ATOM   1553 C CG1 . VAL A 1 218 ? 96.584  102.481 126.883 1.00 28.74 ? 211 VAL H CG1 1 
ATOM   1554 C CG2 . VAL A 1 218 ? 96.947  101.445 124.658 1.00 28.54 ? 211 VAL H CG2 1 
ATOM   1555 N N   . GLU A 1 219 ? 98.983  105.044 126.912 1.00 37.19 ? 212 GLU H N   1 
ATOM   1556 C CA  . GLU A 1 219 ? 99.556  105.794 128.035 1.00 40.16 ? 212 GLU H CA  1 
ATOM   1557 C C   . GLU A 1 219 ? 98.632  106.877 128.554 1.00 42.05 ? 212 GLU H C   1 
ATOM   1558 O O   . GLU A 1 219 ? 97.675  107.249 127.865 1.00 41.37 ? 212 GLU H O   1 
ATOM   1559 C CB  . GLU A 1 219 ? 100.894 106.411 127.629 1.00 40.42 ? 212 GLU H CB  1 
ATOM   1560 C CG  . GLU A 1 219 ? 100.828 107.354 126.435 1.00 41.97 ? 212 GLU H CG  1 
ATOM   1561 C CD  . GLU A 1 219 ? 102.195 107.638 125.824 1.00 42.51 ? 212 GLU H CD  1 
ATOM   1562 O OE1 . GLU A 1 219 ? 103.206 107.623 126.560 1.00 38.97 ? 212 GLU H OE1 1 
ATOM   1563 O OE2 . GLU A 1 219 ? 102.253 107.876 124.598 1.00 43.34 ? 212 GLU H OE2 1 
ATOM   1564 N N   . PRO A 1 220 ? 98.908  107.379 129.784 1.00 46.75 ? 213 PRO H N   1 
ATOM   1565 C CA  . PRO A 1 220 ? 98.322  108.633 130.270 1.00 47.37 ? 213 PRO H CA  1 
ATOM   1566 C C   . PRO A 1 220 ? 98.737  109.823 129.406 1.00 48.76 ? 213 PRO H C   1 
ATOM   1567 O O   . PRO A 1 220 ? 97.875  110.504 128.852 1.00 55.52 ? 213 PRO H O   1 
ATOM   1568 C CB  . PRO A 1 220 ? 98.908  108.777 131.681 1.00 46.85 ? 213 PRO H CB  1 
ATOM   1569 C CG  . PRO A 1 220 ? 99.302  107.409 132.091 1.00 46.32 ? 213 PRO H CG  1 
ATOM   1570 C CD  . PRO A 1 220 ? 99.699  106.706 130.833 1.00 46.88 ? 213 PRO H CD  1 
ATOM   1571 N N   . SER B 2 2   ? 50.774  74.528  117.324 1.00 41.04 ? 0   SER L N   1 
ATOM   1572 C CA  . SER B 2 2   ? 51.976  74.795  116.489 1.00 37.76 ? 0   SER L CA  1 
ATOM   1573 C C   . SER B 2 2   ? 53.055  73.840  116.971 1.00 33.43 ? 0   SER L C   1 
ATOM   1574 O O   . SER B 2 2   ? 52.780  72.669  117.281 1.00 31.91 ? 0   SER L O   1 
ATOM   1575 C CB  . SER B 2 2   ? 52.428  76.271  116.593 1.00 39.71 ? 0   SER L CB  1 
ATOM   1576 O OG  . SER B 2 2   ? 51.392  77.179  116.283 1.00 41.52 ? 0   SER L OG  1 
ATOM   1577 N N   . ASP B 2 3   ? 54.275  74.342  117.061 1.00 30.10 ? 1   ASP L N   1 
ATOM   1578 C CA  . ASP B 2 3   ? 55.391  73.524  117.399 1.00 28.24 ? 1   ASP L CA  1 
ATOM   1579 C C   . ASP B 2 3   ? 55.349  73.268  118.886 1.00 26.34 ? 1   ASP L C   1 
ATOM   1580 O O   . ASP B 2 3   ? 54.960  74.124  119.668 1.00 24.81 ? 1   ASP L O   1 
ATOM   1581 C CB  . ASP B 2 3   ? 56.668  74.225  116.976 1.00 28.97 ? 1   ASP L CB  1 
ATOM   1582 C CG  . ASP B 2 3   ? 56.648  74.608  115.497 1.00 28.78 ? 1   ASP L CG  1 
ATOM   1583 O OD1 . ASP B 2 3   ? 55.783  74.084  114.746 1.00 28.66 ? 1   ASP L OD1 1 
ATOM   1584 O OD2 . ASP B 2 3   ? 57.478  75.445  115.116 1.00 29.66 ? 1   ASP L OD2 1 
ATOM   1585 N N   . ILE B 2 4   ? 55.738  72.063  119.264 1.00 25.29 ? 2   ILE L N   1 
ATOM   1586 C CA  . ILE B 2 4   ? 55.891  71.744  120.658 1.00 23.11 ? 2   ILE L CA  1 
ATOM   1587 C C   . ILE B 2 4   ? 56.960  72.637  121.276 1.00 22.80 ? 2   ILE L C   1 
ATOM   1588 O O   . ILE B 2 4   ? 58.072  72.765  120.772 1.00 22.07 ? 2   ILE L O   1 
ATOM   1589 C CB  . ILE B 2 4   ? 56.166  70.267  120.828 1.00 22.48 ? 2   ILE L CB  1 
ATOM   1590 C CG1 . ILE B 2 4   ? 54.861  69.537  120.505 1.00 22.99 ? 2   ILE L CG1 1 
ATOM   1591 C CG2 . ILE B 2 4   ? 56.613  69.940  122.246 1.00 21.43 ? 2   ILE L CG2 1 
ATOM   1592 C CD1 . ILE B 2 4   ? 55.084  68.110  120.202 1.00 23.24 ? 2   ILE L CD1 1 
ATOM   1593 N N   . GLU B 2 5   ? 56.556  73.282  122.356 1.00 23.11 ? 3   GLU L N   1 
ATOM   1594 C CA  . GLU B 2 5   ? 57.394  74.136  123.131 1.00 24.11 ? 3   GLU L CA  1 
ATOM   1595 C C   . GLU B 2 5   ? 57.961  73.336  124.310 1.00 22.27 ? 3   GLU L C   1 
ATOM   1596 O O   . GLU B 2 5   ? 57.231  72.659  125.033 1.00 19.67 ? 3   GLU L O   1 
ATOM   1597 C CB  . GLU B 2 5   ? 56.566  75.308  123.626 1.00 27.34 ? 3   GLU L CB  1 
ATOM   1598 C CG  . GLU B 2 5   ? 57.362  76.401  124.322 1.00 33.38 ? 3   GLU L CG  1 
ATOM   1599 C CD  . GLU B 2 5   ? 56.474  77.504  124.898 1.00 38.13 ? 3   GLU L CD  1 
ATOM   1600 O OE1 . GLU B 2 5   ? 55.247  77.493  124.649 1.00 42.17 ? 3   GLU L OE1 1 
ATOM   1601 O OE2 . GLU B 2 5   ? 57.003  78.391  125.604 1.00 43.27 ? 3   GLU L OE2 1 
ATOM   1602 N N   . LEU B 2 6   ? 59.275  73.453  124.487 1.00 20.37 ? 4   LEU L N   1 
ATOM   1603 C CA  . LEU B 2 6   ? 59.996  72.846  125.584 1.00 20.00 ? 4   LEU L CA  1 
ATOM   1604 C C   . LEU B 2 6   ? 60.472  74.023  126.441 1.00 20.01 ? 4   LEU L C   1 
ATOM   1605 O O   . LEU B 2 6   ? 61.118  74.944  125.923 1.00 20.25 ? 4   LEU L O   1 
ATOM   1606 C CB  . LEU B 2 6   ? 61.167  71.997  125.060 1.00 19.21 ? 4   LEU L CB  1 
ATOM   1607 C CG  . LEU B 2 6   ? 60.824  70.839  124.111 1.00 19.57 ? 4   LEU L CG  1 
ATOM   1608 C CD1 . LEU B 2 6   ? 62.082  70.025  123.793 1.00 19.73 ? 4   LEU L CD1 1 
ATOM   1609 C CD2 . LEU B 2 6   ? 59.764  69.893  124.643 1.00 20.00 ? 4   LEU L CD2 1 
ATOM   1610 N N   . THR B 2 7   ? 60.134  73.998  127.733 1.00 19.21 ? 5   THR L N   1 
ATOM   1611 C CA  . THR B 2 7   ? 60.382  75.113  128.657 1.00 19.09 ? 5   THR L CA  1 
ATOM   1612 C C   . THR B 2 7   ? 61.373  74.601  129.709 1.00 18.96 ? 5   THR L C   1 
ATOM   1613 O O   . THR B 2 7   ? 61.075  73.665  130.456 1.00 18.52 ? 5   THR L O   1 
ATOM   1614 C CB  . THR B 2 7   ? 59.063  75.579  129.333 1.00 19.59 ? 5   THR L CB  1 
ATOM   1615 O OG1 . THR B 2 7   ? 58.144  76.045  128.336 1.00 18.57 ? 5   THR L OG1 1 
ATOM   1616 C CG2 . THR B 2 7   ? 59.296  76.707  130.362 1.00 19.82 ? 5   THR L CG2 1 
ATOM   1617 N N   . GLN B 2 8   ? 62.569  75.177  129.727 1.00 19.80 ? 6   GLN L N   1 
ATOM   1618 C CA  . GLN B 2 8   ? 63.602  74.753  130.649 1.00 20.26 ? 6   GLN L CA  1 
ATOM   1619 C C   . GLN B 2 8   ? 63.631  75.597  131.891 1.00 22.02 ? 6   GLN L C   1 
ATOM   1620 O O   . GLN B 2 8   ? 63.267  76.761  131.878 1.00 22.76 ? 6   GLN L O   1 
ATOM   1621 C CB  . GLN B 2 8   ? 64.966  74.751  129.980 1.00 20.08 ? 6   GLN L CB  1 
ATOM   1622 C CG  . GLN B 2 8   ? 65.128  73.590  129.037 1.00 19.61 ? 6   GLN L CG  1 
ATOM   1623 C CD  . GLN B 2 8   ? 66.500  73.470  128.456 1.00 19.03 ? 6   GLN L CD  1 
ATOM   1624 O OE1 . GLN B 2 8   ? 66.655  73.486  127.236 1.00 17.70 ? 6   GLN L OE1 1 
ATOM   1625 N NE2 . GLN B 2 8   ? 67.515  73.331  129.317 1.00 19.11 ? 6   GLN L NE2 1 
ATOM   1626 N N   . SER B 2 9   ? 64.083  74.984  132.976 1.00 25.18 ? 7   SER L N   1 
ATOM   1627 C CA  . SER B 2 9   ? 64.170  75.649  134.269 1.00 26.99 ? 7   SER L CA  1 
ATOM   1628 C C   . SER B 2 9   ? 65.267  75.020  135.128 1.00 26.47 ? 7   SER L C   1 
ATOM   1629 O O   . SER B 2 9   ? 65.383  73.792  135.152 1.00 25.30 ? 7   SER L O   1 
ATOM   1630 C CB  . SER B 2 9   ? 62.848  75.522  134.999 1.00 29.78 ? 7   SER L CB  1 
ATOM   1631 O OG  . SER B 2 9   ? 62.825  76.429  136.074 1.00 33.27 ? 7   SER L OG  1 
ATOM   1632 N N   . PRO B 2 10  ? 66.090  75.825  135.813 1.00 25.97 ? 8   PRO L N   1 
ATOM   1633 C CA  . PRO B 2 10  ? 66.110  77.293  135.707 1.00 25.70 ? 8   PRO L CA  1 
ATOM   1634 C C   . PRO B 2 10  ? 66.775  77.747  134.406 1.00 26.38 ? 8   PRO L C   1 
ATOM   1635 O O   . PRO B 2 10  ? 67.228  76.924  133.623 1.00 26.72 ? 8   PRO L O   1 
ATOM   1636 C CB  . PRO B 2 10  ? 66.962  77.701  136.905 1.00 24.54 ? 8   PRO L CB  1 
ATOM   1637 C CG  . PRO B 2 10  ? 67.915  76.574  137.049 1.00 25.09 ? 8   PRO L CG  1 
ATOM   1638 C CD  . PRO B 2 10  ? 67.107  75.340  136.767 1.00 24.90 ? 8   PRO L CD  1 
ATOM   1639 N N   . LEU B 2 11  ? 66.807  79.049  134.194 1.00 26.30 ? 9   LEU L N   1 
ATOM   1640 C CA  . LEU B 2 11  ? 67.507  79.651  133.070 1.00 28.04 ? 9   LEU L CA  1 
ATOM   1641 C C   . LEU B 2 11  ? 69.023  79.632  133.321 1.00 26.85 ? 9   LEU L C   1 
ATOM   1642 O O   . LEU B 2 11  ? 69.839  79.396  132.405 1.00 23.89 ? 9   LEU L O   1 
ATOM   1643 C CB  . LEU B 2 11  ? 66.986  81.077  132.877 1.00 29.65 ? 9   LEU L CB  1 
ATOM   1644 C CG  . LEU B 2 11  ? 67.506  81.960  131.733 1.00 33.90 ? 9   LEU L CG  1 
ATOM   1645 C CD1 . LEU B 2 11  ? 67.749  81.234  130.405 1.00 35.21 ? 9   LEU L CD1 1 
ATOM   1646 C CD2 . LEU B 2 11  ? 66.529  83.118  131.516 1.00 34.89 ? 9   LEU L CD2 1 
ATOM   1647 N N   . SER B 2 12  ? 69.384  79.885  134.576 1.00 26.22 ? 10  SER L N   1 
ATOM   1648 C CA  . SER B 2 12  ? 70.763  79.815  135.034 1.00 27.02 ? 10  SER L CA  1 
ATOM   1649 C C   . SER B 2 12  ? 70.836  79.075  136.358 1.00 26.62 ? 10  SER L C   1 
ATOM   1650 O O   . SER B 2 12  ? 70.024  79.327  137.256 1.00 26.04 ? 10  SER L O   1 
ATOM   1651 C CB  . SER B 2 12  ? 71.352  81.212  135.193 1.00 28.46 ? 10  SER L CB  1 
ATOM   1652 O OG  . SER B 2 12  ? 72.766  81.147  135.037 1.00 32.85 ? 10  SER L OG  1 
ATOM   1653 N N   . LEU B 2 13  ? 71.784  78.142  136.452 1.00 24.90 ? 11  LEU L N   1 
ATOM   1654 C CA  . LEU B 2 13  ? 71.959  77.325  137.631 1.00 24.69 ? 11  LEU L CA  1 
ATOM   1655 C C   . LEU B 2 13  ? 73.385  77.472  138.138 1.00 26.00 ? 11  LEU L C   1 
ATOM   1656 O O   . LEU B 2 13  ? 74.308  76.855  137.592 1.00 26.82 ? 11  LEU L O   1 
ATOM   1657 C CB  . LEU B 2 13  ? 71.635  75.842  137.351 1.00 24.62 ? 11  LEU L CB  1 
ATOM   1658 C CG  . LEU B 2 13  ? 71.640  74.923  138.584 1.00 24.40 ? 11  LEU L CG  1 
ATOM   1659 C CD1 . LEU B 2 13  ? 70.748  75.461  139.704 1.00 24.94 ? 11  LEU L CD1 1 
ATOM   1660 C CD2 . LEU B 2 13  ? 71.207  73.516  138.229 1.00 24.94 ? 11  LEU L CD2 1 
ATOM   1661 N N   . PRO B 2 14  ? 73.583  78.295  139.188 1.00 28.22 ? 12  PRO L N   1 
ATOM   1662 C CA  . PRO B 2 14  ? 74.911  78.350  139.803 1.00 29.31 ? 12  PRO L CA  1 
ATOM   1663 C C   . PRO B 2 14  ? 75.117  77.167  140.751 1.00 28.69 ? 12  PRO L C   1 
ATOM   1664 O O   . PRO B 2 14  ? 74.219  76.840  141.511 1.00 30.02 ? 12  PRO L O   1 
ATOM   1665 C CB  . PRO B 2 14  ? 74.901  79.682  140.562 1.00 29.27 ? 12  PRO L CB  1 
ATOM   1666 C CG  . PRO B 2 14  ? 73.472  80.120  140.633 1.00 29.72 ? 12  PRO L CG  1 
ATOM   1667 C CD  . PRO B 2 14  ? 72.612  79.111  139.936 1.00 28.68 ? 12  PRO L CD  1 
ATOM   1668 N N   . VAL B 2 15  ? 76.274  76.526  140.664 1.00 28.95 ? 13  VAL L N   1 
ATOM   1669 C CA  . VAL B 2 15  ? 76.641  75.414  141.537 1.00 30.21 ? 13  VAL L CA  1 
ATOM   1670 C C   . VAL B 2 15  ? 78.112  75.510  141.931 1.00 31.93 ? 13  VAL L C   1 
ATOM   1671 O O   . VAL B 2 15  ? 78.872  76.230  141.311 1.00 31.24 ? 13  VAL L O   1 
ATOM   1672 C CB  . VAL B 2 15  ? 76.406  74.037  140.875 1.00 30.11 ? 13  VAL L CB  1 
ATOM   1673 C CG1 . VAL B 2 15  ? 74.916  73.799  140.669 1.00 31.24 ? 13  VAL L CG1 1 
ATOM   1674 C CG2 . VAL B 2 15  ? 77.156  73.905  139.555 1.00 29.41 ? 13  VAL L CG2 1 
ATOM   1675 N N   . SER B 2 16  ? 78.505  74.777  142.970 1.00 34.12 ? 14  SER L N   1 
ATOM   1676 C CA  . SER B 2 16  ? 79.925  74.636  143.314 1.00 33.11 ? 14  SER L CA  1 
ATOM   1677 C C   . SER B 2 16  ? 80.427  73.313  142.787 1.00 32.63 ? 14  SER L C   1 
ATOM   1678 O O   . SER B 2 16  ? 79.671  72.356  142.694 1.00 32.22 ? 14  SER L O   1 
ATOM   1679 C CB  . SER B 2 16  ? 80.123  74.725  144.824 1.00 33.96 ? 14  SER L CB  1 
ATOM   1680 O OG  . SER B 2 16  ? 79.692  75.989  145.301 1.00 33.53 ? 14  SER L OG  1 
ATOM   1681 N N   . LEU B 2 17  ? 81.705  73.254  142.432 1.00 34.36 ? 15  LEU L N   1 
ATOM   1682 C CA  . LEU B 2 17  ? 82.301  71.996  141.990 1.00 37.33 ? 15  LEU L CA  1 
ATOM   1683 C C   . LEU B 2 17  ? 82.087  70.891  143.019 1.00 38.04 ? 15  LEU L C   1 
ATOM   1684 O O   . LEU B 2 17  ? 82.132  71.139  144.214 1.00 37.97 ? 15  LEU L O   1 
ATOM   1685 C CB  . LEU B 2 17  ? 83.790  72.166  141.702 1.00 40.02 ? 15  LEU L CB  1 
ATOM   1686 C CG  . LEU B 2 17  ? 84.232  72.915  140.433 1.00 41.74 ? 15  LEU L CG  1 
ATOM   1687 C CD1 . LEU B 2 17  ? 85.597  72.401  139.998 1.00 42.56 ? 15  LEU L CD1 1 
ATOM   1688 C CD2 . LEU B 2 17  ? 83.259  72.795  139.266 1.00 41.98 ? 15  LEU L CD2 1 
ATOM   1689 N N   . GLY B 2 18  ? 81.813  69.681  142.537 1.00 40.89 ? 16  GLY L N   1 
ATOM   1690 C CA  . GLY B 2 18  ? 81.428  68.560  143.398 1.00 40.14 ? 16  GLY L CA  1 
ATOM   1691 C C   . GLY B 2 18  ? 79.965  68.516  143.826 1.00 39.94 ? 16  GLY L C   1 
ATOM   1692 O O   . GLY B 2 18  ? 79.539  67.521  144.407 1.00 41.89 ? 16  GLY L O   1 
ATOM   1693 N N   . ASP B 2 19  ? 79.184  69.559  143.540 1.00 40.07 ? 17  ASP L N   1 
ATOM   1694 C CA  . ASP B 2 19  ? 77.745  69.571  143.882 1.00 39.81 ? 17  ASP L CA  1 
ATOM   1695 C C   . ASP B 2 19  ? 76.882  68.686  143.000 1.00 36.95 ? 17  ASP L C   1 
ATOM   1696 O O   . ASP B 2 19  ? 77.312  68.192  141.962 1.00 33.41 ? 17  ASP L O   1 
ATOM   1697 C CB  . ASP B 2 19  ? 77.151  70.986  143.786 1.00 42.76 ? 17  ASP L CB  1 
ATOM   1698 C CG  . ASP B 2 19  ? 77.320  71.783  145.044 1.00 45.35 ? 17  ASP L CG  1 
ATOM   1699 O OD1 . ASP B 2 19  ? 77.890  71.261  146.021 1.00 45.17 ? 17  ASP L OD1 1 
ATOM   1700 O OD2 . ASP B 2 19  ? 76.851  72.943  145.056 1.00 51.47 ? 17  ASP L OD2 1 
ATOM   1701 N N   . GLN B 2 20  ? 75.642  68.538  143.453 1.00 37.12 ? 18  GLN L N   1 
ATOM   1702 C CA  . GLN B 2 20  ? 74.553  67.922  142.709 1.00 39.49 ? 18  GLN L CA  1 
ATOM   1703 C C   . GLN B 2 20  ? 73.855  69.036  141.908 1.00 36.93 ? 18  GLN L C   1 
ATOM   1704 O O   . GLN B 2 20  ? 73.602  70.116  142.460 1.00 36.77 ? 18  GLN L O   1 
ATOM   1705 C CB  . GLN B 2 20  ? 73.570  67.284  143.705 1.00 42.39 ? 18  GLN L CB  1 
ATOM   1706 C CG  . GLN B 2 20  ? 72.855  66.033  143.219 1.00 47.24 ? 18  GLN L CG  1 
ATOM   1707 C CD  . GLN B 2 20  ? 71.698  66.292  142.273 1.00 50.95 ? 18  GLN L CD  1 
ATOM   1708 O OE1 . GLN B 2 20  ? 70.913  67.228  142.456 1.00 53.88 ? 18  GLN L OE1 1 
ATOM   1709 N NE2 . GLN B 2 20  ? 71.568  65.438  141.260 1.00 55.58 ? 18  GLN L NE2 1 
ATOM   1710 N N   . ALA B 2 21  ? 73.564  68.792  140.625 1.00 33.86 ? 19  ALA L N   1 
ATOM   1711 C CA  . ALA B 2 21  ? 72.756  69.729  139.811 1.00 32.10 ? 19  ALA L CA  1 
ATOM   1712 C C   . ALA B 2 21  ? 71.519  69.039  139.263 1.00 30.66 ? 19  ALA L C   1 
ATOM   1713 O O   . ALA B 2 21  ? 71.581  67.868  138.868 1.00 32.27 ? 19  ALA L O   1 
ATOM   1714 C CB  . ALA B 2 21  ? 73.573  70.300  138.671 1.00 31.83 ? 19  ALA L CB  1 
ATOM   1715 N N   . SER B 2 22  ? 70.411  69.771  139.238 1.00 28.80 ? 20  SER L N   1 
ATOM   1716 C CA  . SER B 2 22  ? 69.158  69.275  138.691 1.00 30.55 ? 20  SER L CA  1 
ATOM   1717 C C   . SER B 2 22  ? 68.522  70.313  137.745 1.00 29.13 ? 20  SER L C   1 
ATOM   1718 O O   . SER B 2 22  ? 68.278  71.446  138.136 1.00 28.85 ? 20  SER L O   1 
ATOM   1719 C CB  . SER B 2 22  ? 68.208  68.914  139.822 1.00 31.10 ? 20  SER L CB  1 
ATOM   1720 O OG  . SER B 2 22  ? 67.158  68.122  139.326 1.00 34.54 ? 20  SER L OG  1 
ATOM   1721 N N   . ILE B 2 23  ? 68.265  69.904  136.505 1.00 28.34 ? 21  ILE L N   1 
ATOM   1722 C CA  . ILE B 2 23  ? 67.735  70.782  135.453 1.00 27.04 ? 21  ILE L CA  1 
ATOM   1723 C C   . ILE B 2 23  ? 66.485  70.140  134.912 1.00 24.26 ? 21  ILE L C   1 
ATOM   1724 O O   . ILE B 2 23  ? 66.458  68.944  134.634 1.00 24.65 ? 21  ILE L O   1 
ATOM   1725 C CB  . ILE B 2 23  ? 68.757  70.964  134.305 1.00 28.76 ? 21  ILE L CB  1 
ATOM   1726 C CG1 . ILE B 2 23  ? 69.960  71.766  134.807 1.00 30.43 ? 21  ILE L CG1 1 
ATOM   1727 C CG2 . ILE B 2 23  ? 68.145  71.676  133.098 1.00 31.10 ? 21  ILE L CG2 1 
ATOM   1728 C CD1 . ILE B 2 23  ? 71.171  71.665  133.888 1.00 31.57 ? 21  ILE L CD1 1 
ATOM   1729 N N   . SER B 2 24  ? 65.463  70.945  134.721 1.00 22.66 ? 22  SER L N   1 
ATOM   1730 C CA  . SER B 2 24  ? 64.207  70.436  134.237 1.00 22.80 ? 22  SER L CA  1 
ATOM   1731 C C   . SER B 2 24  ? 63.781  70.965  132.863 1.00 21.03 ? 22  SER L C   1 
ATOM   1732 O O   . SER B 2 24  ? 64.260  71.987  132.345 1.00 18.70 ? 22  SER L O   1 
ATOM   1733 C CB  . SER B 2 24  ? 63.123  70.673  135.279 1.00 24.90 ? 22  SER L CB  1 
ATOM   1734 O OG  . SER B 2 24  ? 62.566  71.949  135.132 1.00 28.16 ? 22  SER L OG  1 
ATOM   1735 N N   . CYS B 2 25  ? 62.855  70.227  132.280 1.00 20.34 ? 23  CYS L N   1 
ATOM   1736 C CA  . CYS B 2 25  ? 62.373  70.525  130.949 1.00 18.85 ? 23  CYS L CA  1 
ATOM   1737 C C   . CYS B 2 25  ? 60.951  70.088  130.863 1.00 19.08 ? 23  CYS L C   1 
ATOM   1738 O O   . CYS B 2 25  ? 60.648  68.932  131.055 1.00 19.55 ? 23  CYS L O   1 
ATOM   1739 C CB  . CYS B 2 25  ? 63.243  69.827  129.906 1.00 18.92 ? 23  CYS L CB  1 
ATOM   1740 S SG  . CYS B 2 25  ? 62.680  69.969  128.175 1.00 18.64 ? 23  CYS L SG  1 
ATOM   1741 N N   . THR B 2 26  ? 60.072  71.031  130.578 1.00 19.21 ? 24  THR L N   1 
ATOM   1742 C CA  . THR B 2 26  ? 58.654  70.732  130.421 1.00 19.84 ? 24  THR L CA  1 
ATOM   1743 C C   . THR B 2 26  ? 58.210  70.874  128.972 1.00 19.13 ? 24  THR L C   1 
ATOM   1744 O O   . THR B 2 26  ? 58.574  71.828  128.291 1.00 19.42 ? 24  THR L O   1 
ATOM   1745 C CB  . THR B 2 26  ? 57.791  71.635  131.332 1.00 20.59 ? 24  THR L CB  1 
ATOM   1746 O OG1 . THR B 2 26  ? 58.137  71.386  132.707 1.00 22.23 ? 24  THR L OG1 1 
ATOM   1747 C CG2 . THR B 2 26  ? 56.344  71.303  131.170 1.00 21.32 ? 24  THR L CG2 1 
ATOM   1748 N N   . SER B 2 27  ? 57.357  69.953  128.544 1.00 18.35 ? 25  SER L N   1 
ATOM   1749 C CA  . SER B 2 27  ? 56.852  69.902  127.177 1.00 17.99 ? 25  SER L CA  1 
ATOM   1750 C C   . SER B 2 27  ? 55.377  70.324  127.064 1.00 17.94 ? 25  SER L C   1 
ATOM   1751 O O   . SER B 2 27  ? 54.547  69.918  127.862 1.00 18.32 ? 25  SER L O   1 
ATOM   1752 C CB  . SER B 2 27  ? 57.017  68.485  126.678 1.00 18.34 ? 25  SER L CB  1 
ATOM   1753 O OG  . SER B 2 27  ? 56.567  68.392  125.351 1.00 18.52 ? 25  SER L OG  1 
ATOM   1754 N N   . SER B 2 28  ? 55.039  71.117  126.060 1.00 17.32 ? 26  SER L N   1 
ATOM   1755 C CA  . SER B 2 28  ? 53.651  71.519  125.850 1.00 17.65 ? 26  SER L CA  1 
ATOM   1756 C C   . SER B 2 28  ? 52.768  70.350  125.393 1.00 18.05 ? 26  SER L C   1 
ATOM   1757 O O   . SER B 2 28  ? 51.558  70.462  125.470 1.00 17.87 ? 26  SER L O   1 
ATOM   1758 C CB  . SER B 2 28  ? 53.558  72.679  124.858 1.00 18.01 ? 26  SER L CB  1 
ATOM   1759 O OG  . SER B 2 28  ? 53.919  72.265  123.541 1.00 18.68 ? 26  SER L OG  1 
ATOM   1760 N N   . GLN B 2 29  ? 53.352  69.256  124.892 1.00 17.51 ? 27  GLN L N   1 
ATOM   1761 C CA  . GLN B 2 29  ? 52.588  68.057  124.563 1.00 18.41 ? 27  GLN L CA  1 
ATOM   1762 C C   . GLN B 2 29  ? 53.299  66.836  125.057 1.00 18.84 ? 27  GLN L C   1 
ATOM   1763 O O   . GLN B 2 29  ? 54.513  66.849  125.308 1.00 18.41 ? 27  GLN L O   1 
ATOM   1764 C CB  . GLN B 2 29  ? 52.402  67.869  123.052 1.00 19.99 ? 27  GLN L CB  1 
ATOM   1765 C CG  . GLN B 2 29  ? 51.548  68.897  122.348 1.00 20.98 ? 27  GLN L CG  1 
ATOM   1766 C CD  . GLN B 2 29  ? 50.079  68.784  122.704 1.00 23.00 ? 27  GLN L CD  1 
ATOM   1767 O OE1 . GLN B 2 29  ? 49.540  67.682  122.859 1.00 23.76 ? 27  GLN L OE1 1 
ATOM   1768 N NE2 . GLN B 2 29  ? 49.420  69.925  122.829 1.00 23.79 ? 27  GLN L NE2 1 
ATOM   1769 N N   . SER B 2 30  A 52.527  65.759  125.135 1.00 18.68 ? 27  SER L N   1 
ATOM   1770 C CA  . SER B 2 30  A 53.051  64.459  125.455 1.00 19.06 ? 27  SER L CA  1 
ATOM   1771 C C   . SER B 2 30  A 54.102  64.080  124.416 1.00 18.29 ? 27  SER L C   1 
ATOM   1772 O O   . SER B 2 30  A 53.869  64.225  123.236 1.00 18.95 ? 27  SER L O   1 
ATOM   1773 C CB  . SER B 2 30  A 51.940  63.416  125.412 1.00 19.04 ? 27  SER L CB  1 
ATOM   1774 O OG  . SER B 2 30  A 52.522  62.112  125.343 1.00 20.04 ? 27  SER L OG  1 
ATOM   1775 N N   . LEU B 2 31  B 55.218  63.554  124.878 1.00 18.58 ? 27  LEU L N   1 
ATOM   1776 C CA  . LEU B 2 31  B 56.316  63.114  124.010 1.00 18.96 ? 27  LEU L CA  1 
ATOM   1777 C C   . LEU B 2 31  B 56.376  61.606  123.866 1.00 19.71 ? 27  LEU L C   1 
ATOM   1778 O O   . LEU B 2 31  B 57.336  61.058  123.287 1.00 18.78 ? 27  LEU L O   1 
ATOM   1779 C CB  . LEU B 2 31  B 57.646  63.650  124.552 1.00 19.07 ? 27  LEU L CB  1 
ATOM   1780 C CG  . LEU B 2 31  B 57.722  65.174  124.664 1.00 18.42 ? 27  LEU L CG  1 
ATOM   1781 C CD1 . LEU B 2 31  B 59.123  65.576  125.086 1.00 18.58 ? 27  LEU L CD1 1 
ATOM   1782 C CD2 . LEU B 2 31  B 57.343  65.855  123.357 1.00 17.92 ? 27  LEU L CD2 1 
ATOM   1783 N N   . LEU B 2 32  C 55.332  60.929  124.358 1.00 19.93 ? 27  LEU L N   1 
ATOM   1784 C CA  . LEU B 2 32  C 55.228  59.502  124.206 1.00 20.01 ? 27  LEU L CA  1 
ATOM   1785 C C   . LEU B 2 32  C 54.870  59.213  122.768 1.00 20.01 ? 27  LEU L C   1 
ATOM   1786 O O   . LEU B 2 32  C 53.893  59.756  122.266 1.00 20.54 ? 27  LEU L O   1 
ATOM   1787 C CB  . LEU B 2 32  C 54.169  58.952  125.149 1.00 20.97 ? 27  LEU L CB  1 
ATOM   1788 C CG  . LEU B 2 32  C 53.978  57.439  125.168 1.00 20.64 ? 27  LEU L CG  1 
ATOM   1789 C CD1 . LEU B 2 32  C 55.193  56.721  125.734 1.00 20.61 ? 27  LEU L CD1 1 
ATOM   1790 C CD2 . LEU B 2 32  C 52.719  57.103  125.955 1.00 20.59 ? 27  LEU L CD2 1 
ATOM   1791 N N   . HIS B 2 33  D 55.693  58.402  122.104 1.00 19.75 ? 27  HIS L N   1 
ATOM   1792 C CA  . HIS B 2 33  D 55.458  57.981  120.731 1.00 22.09 ? 27  HIS L CA  1 
ATOM   1793 C C   . HIS B 2 33  D 54.554  56.724  120.728 1.00 23.38 ? 27  HIS L C   1 
ATOM   1794 O O   . HIS B 2 33  D 54.471  56.003  121.735 1.00 22.34 ? 27  HIS L O   1 
ATOM   1795 C CB  . HIS B 2 33  D 56.798  57.686  120.043 1.00 23.08 ? 27  HIS L CB  1 
ATOM   1796 C CG  . HIS B 2 33  D 56.716  57.604  118.549 1.00 24.88 ? 27  HIS L CG  1 
ATOM   1797 N ND1 . HIS B 2 33  D 56.554  56.415  117.872 1.00 27.09 ? 27  HIS L ND1 1 
ATOM   1798 C CD2 . HIS B 2 33  D 56.764  58.562  117.600 1.00 26.56 ? 27  HIS L CD2 1 
ATOM   1799 C CE1 . HIS B 2 33  D 56.508  56.640  116.576 1.00 25.73 ? 27  HIS L CE1 1 
ATOM   1800 N NE2 . HIS B 2 33  D 56.624  57.939  116.385 1.00 26.76 ? 27  HIS L NE2 1 
ATOM   1801 N N   . SER B 2 34  E 53.884  56.462  119.608 1.00 23.87 ? 27  SER L N   1 
ATOM   1802 C CA  . SER B 2 34  E 53.044  55.248  119.478 1.00 26.13 ? 27  SER L CA  1 
ATOM   1803 C C   . SER B 2 34  E 53.811  53.904  119.519 1.00 25.15 ? 27  SER L C   1 
ATOM   1804 O O   . SER B 2 34  E 53.216  52.866  119.734 1.00 27.40 ? 27  SER L O   1 
ATOM   1805 C CB  . SER B 2 34  E 52.173  55.327  118.211 1.00 27.39 ? 27  SER L CB  1 
ATOM   1806 O OG  . SER B 2 34  E 52.950  55.211  117.036 1.00 28.92 ? 27  SER L OG  1 
ATOM   1807 N N   . ASN B 2 35  ? 55.127  53.941  119.353 1.00 24.08 ? 28  ASN L N   1 
ATOM   1808 C CA  . ASN B 2 35  ? 56.027  52.782  119.532 1.00 22.23 ? 28  ASN L CA  1 
ATOM   1809 C C   . ASN B 2 35  ? 56.455  52.537  120.986 1.00 21.70 ? 28  ASN L C   1 
ATOM   1810 O O   . ASN B 2 35  ? 57.302  51.685  121.267 1.00 21.70 ? 28  ASN L O   1 
ATOM   1811 C CB  . ASN B 2 35  ? 57.271  52.921  118.626 1.00 22.46 ? 28  ASN L CB  1 
ATOM   1812 C CG  . ASN B 2 35  ? 58.287  53.989  119.094 1.00 22.67 ? 28  ASN L CG  1 
ATOM   1813 O OD1 . ASN B 2 35  ? 58.214  54.576  120.184 1.00 22.23 ? 28  ASN L OD1 1 
ATOM   1814 N ND2 . ASN B 2 35  ? 59.251  54.227  118.248 1.00 23.07 ? 28  ASN L ND2 1 
ATOM   1815 N N   . GLY B 2 36  ? 55.903  53.328  121.899 1.00 21.53 ? 29  GLY L N   1 
ATOM   1816 C CA  . GLY B 2 36  ? 56.192  53.229  123.320 1.00 21.85 ? 29  GLY L CA  1 
ATOM   1817 C C   . GLY B 2 36  ? 57.339  54.091  123.821 1.00 22.37 ? 29  GLY L C   1 
ATOM   1818 O O   . GLY B 2 36  ? 57.481  54.293  125.022 1.00 21.86 ? 29  GLY L O   1 
ATOM   1819 N N   . ASP B 2 37  ? 58.171  54.604  122.921 1.00 23.37 ? 30  ASP L N   1 
ATOM   1820 C CA  . ASP B 2 37  ? 59.343  55.352  123.352 1.00 22.53 ? 30  ASP L CA  1 
ATOM   1821 C C   . ASP B 2 37  ? 58.987  56.818  123.557 1.00 20.50 ? 30  ASP L C   1 
ATOM   1822 O O   . ASP B 2 37  ? 57.973  57.305  123.058 1.00 18.33 ? 30  ASP L O   1 
ATOM   1823 C CB  . ASP B 2 37  ? 60.493  55.195  122.351 1.00 25.17 ? 30  ASP L CB  1 
ATOM   1824 C CG  . ASP B 2 37  ? 61.772  54.742  123.013 1.00 28.21 ? 30  ASP L CG  1 
ATOM   1825 O OD1 . ASP B 2 37  ? 62.114  55.283  124.096 1.00 32.78 ? 30  ASP L OD1 1 
ATOM   1826 O OD2 . ASP B 2 37  ? 62.418  53.834  122.457 1.00 29.51 ? 30  ASP L OD2 1 
ATOM   1827 N N   . THR B 2 38  ? 59.841  57.495  124.315 1.00 19.20 ? 31  THR L N   1 
ATOM   1828 C CA  . THR B 2 38  ? 59.699  58.911  124.609 1.00 19.79 ? 31  THR L CA  1 
ATOM   1829 C C   . THR B 2 38  ? 60.958  59.630  124.131 1.00 19.40 ? 31  THR L C   1 
ATOM   1830 O O   . THR B 2 38  ? 62.020  59.500  124.738 1.00 19.58 ? 31  THR L O   1 
ATOM   1831 C CB  . THR B 2 38  ? 59.460  59.121  126.124 1.00 20.72 ? 31  THR L CB  1 
ATOM   1832 O OG1 . THR B 2 38  ? 58.250  58.440  126.516 1.00 21.69 ? 31  THR L OG1 1 
ATOM   1833 C CG2 . THR B 2 38  ? 59.298  60.579  126.462 1.00 20.63 ? 31  THR L CG2 1 
ATOM   1834 N N   . TYR B 2 39  ? 60.830  60.393  123.051 1.00 19.50 ? 32  TYR L N   1 
ATOM   1835 C CA  . TYR B 2 39  ? 61.984  60.998  122.356 1.00 19.83 ? 32  TYR L CA  1 
ATOM   1836 C C   . TYR B 2 39  ? 62.308  62.395  122.873 1.00 19.01 ? 32  TYR L C   1 
ATOM   1837 O O   . TYR B 2 39  ? 62.089  63.394  122.213 1.00 18.36 ? 32  TYR L O   1 
ATOM   1838 C CB  . TYR B 2 39  ? 61.744  61.032  120.859 1.00 19.34 ? 32  TYR L CB  1 
ATOM   1839 C CG  . TYR B 2 39  ? 61.685  59.672  120.282 1.00 19.86 ? 32  TYR L CG  1 
ATOM   1840 C CD1 . TYR B 2 39  ? 62.848  58.992  119.963 1.00 20.48 ? 32  TYR L CD1 1 
ATOM   1841 C CD2 . TYR B 2 39  ? 60.464  59.042  120.070 1.00 20.55 ? 32  TYR L CD2 1 
ATOM   1842 C CE1 . TYR B 2 39  ? 62.813  57.713  119.437 1.00 20.46 ? 32  TYR L CE1 1 
ATOM   1843 C CE2 . TYR B 2 39  ? 60.408  57.769  119.543 1.00 21.31 ? 32  TYR L CE2 1 
ATOM   1844 C CZ  . TYR B 2 39  ? 61.585  57.109  119.235 1.00 21.47 ? 32  TYR L CZ  1 
ATOM   1845 O OH  . TYR B 2 39  ? 61.519  55.852  118.718 1.00 20.76 ? 32  TYR L OH  1 
ATOM   1846 N N   . LEU B 2 40  ? 62.820  62.404  124.089 1.00 19.59 ? 33  LEU L N   1 
ATOM   1847 C CA  . LEU B 2 40  ? 63.254  63.596  124.789 1.00 19.58 ? 33  LEU L CA  1 
ATOM   1848 C C   . LEU B 2 40  ? 64.733  63.378  125.027 1.00 18.32 ? 33  LEU L C   1 
ATOM   1849 O O   . LEU B 2 40  ? 65.114  62.399  125.653 1.00 19.00 ? 33  LEU L O   1 
ATOM   1850 C CB  . LEU B 2 40  ? 62.497  63.730  126.122 1.00 19.61 ? 33  LEU L CB  1 
ATOM   1851 C CG  . LEU B 2 40  ? 62.674  64.984  126.989 1.00 19.17 ? 33  LEU L CG  1 
ATOM   1852 C CD1 . LEU B 2 40  ? 63.987  65.009  127.779 1.00 19.66 ? 33  LEU L CD1 1 
ATOM   1853 C CD2 . LEU B 2 40  ? 62.533  66.268  126.190 1.00 19.16 ? 33  LEU L CD2 1 
ATOM   1854 N N   . HIS B 2 41  ? 65.558  64.289  124.531 1.00 17.58 ? 34  HIS L N   1 
ATOM   1855 C CA  . HIS B 2 41  ? 67.021  64.121  124.515 1.00 16.36 ? 34  HIS L CA  1 
ATOM   1856 C C   . HIS B 2 41  ? 67.675  65.280  125.262 1.00 16.55 ? 34  HIS L C   1 
ATOM   1857 O O   . HIS B 2 41  ? 67.128  66.397  125.285 1.00 15.47 ? 34  HIS L O   1 
ATOM   1858 C CB  . HIS B 2 41  ? 67.516  64.130  123.068 1.00 16.45 ? 34  HIS L CB  1 
ATOM   1859 C CG  . HIS B 2 41  ? 66.650  63.363  122.116 1.00 16.42 ? 34  HIS L CG  1 
ATOM   1860 N ND1 . HIS B 2 41  ? 66.551  61.995  122.149 1.00 16.90 ? 34  HIS L ND1 1 
ATOM   1861 C CD2 . HIS B 2 41  ? 65.863  63.764  121.092 1.00 16.83 ? 34  HIS L CD2 1 
ATOM   1862 C CE1 . HIS B 2 41  ? 65.740  61.577  121.195 1.00 17.06 ? 34  HIS L CE1 1 
ATOM   1863 N NE2 . HIS B 2 41  ? 65.311  62.634  120.535 1.00 17.12 ? 34  HIS L NE2 1 
ATOM   1864 N N   . TRP B 2 42  ? 68.850  65.040  125.841 1.00 16.19 ? 35  TRP L N   1 
ATOM   1865 C CA  . TRP B 2 42  ? 69.578  66.077  126.576 1.00 16.51 ? 35  TRP L CA  1 
ATOM   1866 C C   . TRP B 2 42  ? 70.980  66.291  125.986 1.00 16.60 ? 35  TRP L C   1 
ATOM   1867 O O   . TRP B 2 42  ? 71.723  65.329  125.814 1.00 15.31 ? 35  TRP L O   1 
ATOM   1868 C CB  . TRP B 2 42  ? 69.741  65.701  128.053 1.00 17.20 ? 35  TRP L CB  1 
ATOM   1869 C CG  . TRP B 2 42  ? 68.502  65.787  128.896 1.00 17.70 ? 35  TRP L CG  1 
ATOM   1870 C CD1 . TRP B 2 42  ? 67.707  64.758  129.284 1.00 18.27 ? 35  TRP L CD1 1 
ATOM   1871 C CD2 . TRP B 2 42  ? 67.955  66.971  129.493 1.00 17.92 ? 35  TRP L CD2 1 
ATOM   1872 N NE1 . TRP B 2 42  ? 66.679  65.226  130.088 1.00 18.75 ? 35  TRP L NE1 1 
ATOM   1873 C CE2 . TRP B 2 42  ? 66.807  66.583  130.224 1.00 17.97 ? 35  TRP L CE2 1 
ATOM   1874 C CE3 . TRP B 2 42  ? 68.335  68.317  129.497 1.00 18.10 ? 35  TRP L CE3 1 
ATOM   1875 C CZ2 . TRP B 2 42  ? 66.038  67.490  130.948 1.00 17.83 ? 35  TRP L CZ2 1 
ATOM   1876 C CZ3 . TRP B 2 42  ? 67.569  69.222  130.203 1.00 18.30 ? 35  TRP L CZ3 1 
ATOM   1877 C CH2 . TRP B 2 42  ? 66.425  68.806  130.920 1.00 18.53 ? 35  TRP L CH2 1 
ATOM   1878 N N   . TYR B 2 43  ? 71.333  67.558  125.754 1.00 16.19 ? 36  TYR L N   1 
ATOM   1879 C CA  . TYR B 2 43  ? 72.629  67.956  125.214 1.00 16.94 ? 36  TYR L CA  1 
ATOM   1880 C C   . TYR B 2 43  ? 73.351  68.906  126.148 1.00 16.54 ? 36  TYR L C   1 
ATOM   1881 O O   . TYR B 2 43  ? 72.717  69.674  126.861 1.00 15.08 ? 36  TYR L O   1 
ATOM   1882 C CB  . TYR B 2 43  ? 72.458  68.717  123.904 1.00 17.95 ? 36  TYR L CB  1 
ATOM   1883 C CG  . TYR B 2 43  ? 71.888  67.891  122.797 1.00 20.02 ? 36  TYR L CG  1 
ATOM   1884 C CD1 . TYR B 2 43  ? 70.512  67.685  122.700 1.00 20.85 ? 36  TYR L CD1 1 
ATOM   1885 C CD2 . TYR B 2 43  ? 72.710  67.296  121.854 1.00 21.07 ? 36  TYR L CD2 1 
ATOM   1886 C CE1 . TYR B 2 43  ? 69.977  66.919  121.684 1.00 22.13 ? 36  TYR L CE1 1 
ATOM   1887 C CE2 . TYR B 2 43  ? 72.179  66.521  120.833 1.00 22.06 ? 36  TYR L CE2 1 
ATOM   1888 C CZ  . TYR B 2 43  ? 70.813  66.340  120.759 1.00 22.49 ? 36  TYR L CZ  1 
ATOM   1889 O OH  . TYR B 2 43  ? 70.285  65.578  119.759 1.00 25.02 ? 36  TYR L OH  1 
ATOM   1890 N N   . LEU B 2 44  ? 74.680  68.872  126.074 1.00 16.39 ? 37  LEU L N   1 
ATOM   1891 C CA  . LEU B 2 44  ? 75.543  69.901  126.645 1.00 16.39 ? 37  LEU L CA  1 
ATOM   1892 C C   . LEU B 2 44  ? 76.317  70.600  125.552 1.00 16.72 ? 37  LEU L C   1 
ATOM   1893 O O   . LEU B 2 44  ? 76.965  69.950  124.742 1.00 16.83 ? 37  LEU L O   1 
ATOM   1894 C CB  . LEU B 2 44  ? 76.542  69.314  127.640 1.00 16.58 ? 37  LEU L CB  1 
ATOM   1895 C CG  . LEU B 2 44  ? 77.682  70.265  128.075 1.00 16.71 ? 37  LEU L CG  1 
ATOM   1896 C CD1 . LEU B 2 44  ? 77.159  71.502  128.764 1.00 16.54 ? 37  LEU L CD1 1 
ATOM   1897 C CD2 . LEU B 2 44  ? 78.648  69.544  129.002 1.00 17.66 ? 37  LEU L CD2 1 
ATOM   1898 N N   . GLN B 2 45  ? 76.247  71.923  125.534 1.00 17.62 ? 38  GLN L N   1 
ATOM   1899 C CA  . GLN B 2 45  ? 77.061  72.706  124.644 1.00 19.20 ? 38  GLN L CA  1 
ATOM   1900 C C   . GLN B 2 45  ? 78.064  73.534  125.414 1.00 19.97 ? 38  GLN L C   1 
ATOM   1901 O O   . GLN B 2 45  ? 77.697  74.411  126.186 1.00 18.35 ? 38  GLN L O   1 
ATOM   1902 C CB  . GLN B 2 45  ? 76.210  73.640  123.805 1.00 20.03 ? 38  GLN L CB  1 
ATOM   1903 C CG  . GLN B 2 45  ? 77.017  74.382  122.756 1.00 19.55 ? 38  GLN L CG  1 
ATOM   1904 C CD  . GLN B 2 45  ? 76.118  75.120  121.791 1.00 19.33 ? 38  GLN L CD  1 
ATOM   1905 O OE1 . GLN B 2 45  ? 75.104  75.643  122.190 1.00 18.63 ? 38  GLN L OE1 1 
ATOM   1906 N NE2 . GLN B 2 45  ? 76.511  75.194  120.527 1.00 18.82 ? 38  GLN L NE2 1 
ATOM   1907 N N   . LYS B 2 46  ? 79.329  73.249  125.151 1.00 22.63 ? 39  LYS L N   1 
ATOM   1908 C CA  . LYS B 2 46  ? 80.436  74.022  125.671 1.00 25.39 ? 39  LYS L CA  1 
ATOM   1909 C C   . LYS B 2 46  ? 80.629  75.226  124.757 1.00 24.52 ? 39  LYS L C   1 
ATOM   1910 O O   . LYS B 2 46  ? 80.352  75.136  123.561 1.00 23.30 ? 39  LYS L O   1 
ATOM   1911 C CB  . LYS B 2 46  ? 81.731  73.199  125.659 1.00 27.82 ? 39  LYS L CB  1 
ATOM   1912 C CG  . LYS B 2 46  ? 81.647  71.813  126.271 1.00 29.48 ? 39  LYS L CG  1 
ATOM   1913 C CD  . LYS B 2 46  ? 81.517  71.873  127.763 1.00 32.30 ? 39  LYS L CD  1 
ATOM   1914 C CE  . LYS B 2 46  ? 82.872  71.784  128.444 1.00 35.61 ? 39  LYS L CE  1 
ATOM   1915 N NZ  . LYS B 2 46  ? 82.801  72.372  129.813 1.00 36.16 ? 39  LYS L NZ  1 
ATOM   1916 N N   . PRO B 2 47  ? 81.157  76.337  125.300 1.00 26.35 ? 40  PRO L N   1 
ATOM   1917 C CA  . PRO B 2 47  ? 81.387  77.547  124.494 1.00 25.44 ? 40  PRO L CA  1 
ATOM   1918 C C   . PRO B 2 47  ? 82.293  77.298  123.296 1.00 23.81 ? 40  PRO L C   1 
ATOM   1919 O O   . PRO B 2 47  ? 83.307  76.631  123.435 1.00 25.89 ? 40  PRO L O   1 
ATOM   1920 C CB  . PRO B 2 47  ? 82.068  78.512  125.478 1.00 27.19 ? 40  PRO L CB  1 
ATOM   1921 C CG  . PRO B 2 47  ? 81.848  77.952  126.846 1.00 26.80 ? 40  PRO L CG  1 
ATOM   1922 C CD  . PRO B 2 47  ? 81.690  76.471  126.674 1.00 27.05 ? 40  PRO L CD  1 
ATOM   1923 N N   . GLY B 2 48  ? 81.894  77.778  122.122 1.00 22.43 ? 41  GLY L N   1 
ATOM   1924 C CA  . GLY B 2 48  ? 82.641  77.556  120.878 1.00 22.07 ? 41  GLY L CA  1 
ATOM   1925 C C   . GLY B 2 48  ? 82.694  76.122  120.367 1.00 23.26 ? 41  GLY L C   1 
ATOM   1926 O O   . GLY B 2 48  ? 83.548  75.795  119.532 1.00 23.37 ? 41  GLY L O   1 
ATOM   1927 N N   . GLN B 2 49  ? 81.776  75.279  120.854 1.00 21.98 ? 42  GLN L N   1 
ATOM   1928 C CA  . GLN B 2 49  ? 81.684  73.885  120.463 1.00 22.92 ? 42  GLN L CA  1 
ATOM   1929 C C   . GLN B 2 49  ? 80.262  73.570  120.061 1.00 22.08 ? 42  GLN L C   1 
ATOM   1930 O O   . GLN B 2 49  ? 79.316  74.342  120.322 1.00 22.53 ? 42  GLN L O   1 
ATOM   1931 C CB  . GLN B 2 49  ? 82.084  72.926  121.607 1.00 24.33 ? 42  GLN L CB  1 
ATOM   1932 C CG  . GLN B 2 49  ? 83.480  73.105  122.184 1.00 26.31 ? 42  GLN L CG  1 
ATOM   1933 C CD  . GLN B 2 49  ? 84.045  71.857  122.872 1.00 29.01 ? 42  GLN L CD  1 
ATOM   1934 O OE1 . GLN B 2 49  ? 83.511  70.744  122.760 1.00 33.10 ? 42  GLN L OE1 1 
ATOM   1935 N NE2 . GLN B 2 49  ? 85.146  72.041  123.587 1.00 29.90 ? 42  GLN L NE2 1 
ATOM   1936 N N   . SER B 2 50  ? 80.112  72.415  119.442 1.00 20.36 ? 43  SER L N   1 
ATOM   1937 C CA  . SER B 2 50  ? 78.810  71.962  119.028 1.00 21.14 ? 43  SER L CA  1 
ATOM   1938 C C   . SER B 2 50  ? 78.131  71.251  120.197 1.00 20.08 ? 43  SER L C   1 
ATOM   1939 O O   . SER B 2 50  ? 78.816  70.742  121.078 1.00 19.66 ? 43  SER L O   1 
ATOM   1940 C CB  . SER B 2 50  ? 78.930  71.048  117.811 1.00 20.94 ? 43  SER L CB  1 
ATOM   1941 O OG  . SER B 2 50  ? 79.550  69.858  118.180 1.00 22.47 ? 43  SER L OG  1 
ATOM   1942 N N   . PRO B 2 51  ? 76.780  71.226  120.212 1.00 19.65 ? 44  PRO L N   1 
ATOM   1943 C CA  . PRO B 2 51  ? 76.060  70.463  121.217 1.00 20.08 ? 44  PRO L CA  1 
ATOM   1944 C C   . PRO B 2 51  ? 76.499  69.021  121.226 1.00 21.55 ? 44  PRO L C   1 
ATOM   1945 O O   . PRO B 2 51  ? 76.759  68.455  120.177 1.00 20.95 ? 44  PRO L O   1 
ATOM   1946 C CB  . PRO B 2 51  ? 74.607  70.567  120.758 1.00 20.00 ? 44  PRO L CB  1 
ATOM   1947 C CG  . PRO B 2 51  ? 74.542  71.900  120.124 1.00 19.68 ? 44  PRO L CG  1 
ATOM   1948 C CD  . PRO B 2 51  ? 75.847  72.001  119.372 1.00 19.63 ? 44  PRO L CD  1 
ATOM   1949 N N   . LYS B 2 52  ? 76.594  68.456  122.416 1.00 22.89 ? 45  LYS L N   1 
ATOM   1950 C CA  . LYS B 2 52  ? 76.977  67.078  122.578 1.00 25.13 ? 45  LYS L CA  1 
ATOM   1951 C C   . LYS B 2 52  ? 75.870  66.337  123.274 1.00 22.57 ? 45  LYS L C   1 
ATOM   1952 O O   . LYS B 2 52  ? 75.452  66.735  124.346 1.00 22.71 ? 45  LYS L O   1 
ATOM   1953 C CB  . LYS B 2 52  ? 78.244  66.960  123.414 1.00 28.98 ? 45  LYS L CB  1 
ATOM   1954 C CG  . LYS B 2 52  ? 78.636  65.507  123.560 1.00 34.58 ? 45  LYS L CG  1 
ATOM   1955 C CD  . LYS B 2 52  ? 79.788  65.273  124.495 1.00 40.14 ? 45  LYS L CD  1 
ATOM   1956 C CE  . LYS B 2 52  ? 80.049  63.775  124.564 1.00 44.76 ? 45  LYS L CE  1 
ATOM   1957 N NZ  . LYS B 2 52  ? 81.193  63.482  125.464 1.00 49.24 ? 45  LYS L NZ  1 
ATOM   1958 N N   . LEU B 2 53  ? 75.442  65.232  122.689 1.00 22.76 ? 46  LEU L N   1 
ATOM   1959 C CA  . LEU B 2 53  ? 74.361  64.421  123.233 1.00 23.27 ? 46  LEU L CA  1 
ATOM   1960 C C   . LEU B 2 53  ? 74.812  63.665  124.473 1.00 24.52 ? 46  LEU L C   1 
ATOM   1961 O O   . LEU B 2 53  ? 75.819  62.960  124.431 1.00 26.06 ? 46  LEU L O   1 
ATOM   1962 C CB  . LEU B 2 53  ? 73.900  63.418  122.197 1.00 23.58 ? 46  LEU L CB  1 
ATOM   1963 C CG  . LEU B 2 53  ? 72.717  62.494  122.551 1.00 22.82 ? 46  LEU L CG  1 
ATOM   1964 C CD1 . LEU B 2 53  ? 71.445  63.248  122.916 1.00 22.04 ? 46  LEU L CD1 1 
ATOM   1965 C CD2 . LEU B 2 53  ? 72.502  61.601  121.347 1.00 22.91 ? 46  LEU L CD2 1 
ATOM   1966 N N   . LEU B 2 54  ? 74.067  63.830  125.563 1.00 23.53 ? 47  LEU L N   1 
ATOM   1967 C CA  . LEU B 2 54  ? 74.340  63.159  126.838 1.00 24.35 ? 47  LEU L CA  1 
ATOM   1968 C C   . LEU B 2 54  ? 73.381  61.997  127.099 1.00 25.18 ? 47  LEU L C   1 
ATOM   1969 O O   . LEU B 2 54  ? 73.813  60.865  127.360 1.00 23.57 ? 47  LEU L O   1 
ATOM   1970 C CB  . LEU B 2 54  ? 74.207  64.162  127.973 1.00 25.69 ? 47  LEU L CB  1 
ATOM   1971 C CG  . LEU B 2 54  ? 75.216  65.324  127.944 1.00 26.73 ? 47  LEU L CG  1 
ATOM   1972 C CD1 . LEU B 2 54  ? 74.854  66.299  129.048 1.00 27.49 ? 47  LEU L CD1 1 
ATOM   1973 C CD2 . LEU B 2 54  ? 76.648  64.837  128.103 1.00 25.92 ? 47  LEU L CD2 1 
ATOM   1974 N N   . ILE B 2 55  ? 72.086  62.301  127.022 1.00 24.52 ? 48  ILE L N   1 
ATOM   1975 C CA  . ILE B 2 55  ? 71.026  61.340  127.254 1.00 25.55 ? 48  ILE L CA  1 
ATOM   1976 C C   . ILE B 2 55  ? 70.070  61.424  126.079 1.00 24.90 ? 48  ILE L C   1 
ATOM   1977 O O   . ILE B 2 55  ? 69.618  62.509  125.747 1.00 22.80 ? 48  ILE L O   1 
ATOM   1978 C CB  . ILE B 2 55  ? 70.232  61.686  128.538 1.00 26.35 ? 48  ILE L CB  1 
ATOM   1979 C CG1 . ILE B 2 55  ? 71.133  61.683  129.787 1.00 28.56 ? 48  ILE L CG1 1 
ATOM   1980 C CG2 . ILE B 2 55  ? 69.040  60.759  128.728 1.00 27.18 ? 48  ILE L CG2 1 
ATOM   1981 C CD1 . ILE B 2 55  ? 71.777  60.348  130.123 1.00 29.40 ? 48  ILE L CD1 1 
ATOM   1982 N N   . TYR B 2 56  ? 69.750  60.281  125.480 1.00 25.09 ? 49  TYR L N   1 
ATOM   1983 C CA  . TYR B 2 56  ? 68.730  60.214  124.448 1.00 26.15 ? 49  TYR L CA  1 
ATOM   1984 C C   . TYR B 2 56  ? 67.570  59.314  124.893 1.00 26.77 ? 49  TYR L C   1 
ATOM   1985 O O   . TYR B 2 56  ? 67.695  58.460  125.782 1.00 25.09 ? 49  TYR L O   1 
ATOM   1986 C CB  . TYR B 2 56  ? 69.305  59.783  123.097 1.00 27.29 ? 49  TYR L CB  1 
ATOM   1987 C CG  . TYR B 2 56  ? 69.796  58.364  123.068 1.00 30.85 ? 49  TYR L CG  1 
ATOM   1988 C CD1 . TYR B 2 56  ? 71.047  58.026  123.576 1.00 32.33 ? 49  TYR L CD1 1 
ATOM   1989 C CD2 . TYR B 2 56  ? 68.998  57.341  122.526 1.00 33.24 ? 49  TYR L CD2 1 
ATOM   1990 C CE1 . TYR B 2 56  ? 71.494  56.707  123.557 1.00 35.38 ? 49  TYR L CE1 1 
ATOM   1991 C CE2 . TYR B 2 56  ? 69.428  56.026  122.497 1.00 34.75 ? 49  TYR L CE2 1 
ATOM   1992 C CZ  . TYR B 2 56  ? 70.671  55.712  123.016 1.00 36.62 ? 49  TYR L CZ  1 
ATOM   1993 O OH  . TYR B 2 56  ? 71.067  54.405  122.973 1.00 41.84 ? 49  TYR L OH  1 
ATOM   1994 N N   . THR B 2 57  ? 66.451  59.545  124.225 1.00 26.89 ? 50  THR L N   1 
ATOM   1995 C CA  . THR B 2 57  ? 65.143  58.986  124.475 1.00 27.56 ? 50  THR L CA  1 
ATOM   1996 C C   . THR B 2 57  ? 64.898  58.756  125.940 1.00 27.48 ? 50  THR L C   1 
ATOM   1997 O O   . THR B 2 57  ? 64.784  57.616  126.384 1.00 28.55 ? 50  THR L O   1 
ATOM   1998 C CB  . THR B 2 57  ? 64.911  57.721  123.632 1.00 27.97 ? 50  THR L CB  1 
ATOM   1999 O OG1 . THR B 2 57  ? 65.770  56.688  124.089 1.00 30.44 ? 50  THR L OG1 1 
ATOM   2000 C CG2 . THR B 2 57  ? 65.239  58.002  122.179 1.00 27.82 ? 50  THR L CG2 1 
ATOM   2001 N N   . LEU B 2 58  ? 64.888  59.875  126.672 1.00 28.10 ? 51  LEU L N   1 
ATOM   2002 C CA  . LEU B 2 58  ? 64.524  59.964  128.093 1.00 29.73 ? 51  LEU L CA  1 
ATOM   2003 C C   . LEU B 2 58  ? 65.677  59.644  129.068 1.00 30.01 ? 51  LEU L C   1 
ATOM   2004 O O   . LEU B 2 58  ? 66.110  60.514  129.843 1.00 30.54 ? 51  LEU L O   1 
ATOM   2005 C CB  . LEU B 2 58  ? 63.268  59.111  128.375 1.00 32.16 ? 51  LEU L CB  1 
ATOM   2006 C CG  . LEU B 2 58  ? 62.711  58.983  129.778 1.00 34.56 ? 51  LEU L CG  1 
ATOM   2007 C CD1 . LEU B 2 58  ? 62.293  60.327  130.316 1.00 35.63 ? 51  LEU L CD1 1 
ATOM   2008 C CD2 . LEU B 2 58  ? 61.534  57.999  129.766 1.00 35.74 ? 51  LEU L CD2 1 
ATOM   2009 N N   . SER B 2 59  ? 66.158  58.410  129.034 1.00 30.56 ? 52  SER L N   1 
ATOM   2010 C CA  . SER B 2 59  ? 67.179  57.933  130.000 1.00 33.76 ? 52  SER L CA  1 
ATOM   2011 C C   . SER B 2 59  ? 68.318  57.063  129.450 1.00 34.46 ? 52  SER L C   1 
ATOM   2012 O O   . SER B 2 59  ? 69.166  56.614  130.218 1.00 39.26 ? 52  SER L O   1 
ATOM   2013 C CB  . SER B 2 59  ? 66.485  57.192  131.165 1.00 33.67 ? 52  SER L CB  1 
ATOM   2014 O OG  . SER B 2 59  ? 65.475  56.322  130.706 1.00 33.04 ? 52  SER L OG  1 
ATOM   2015 N N   . ASN B 2 60  ? 68.357  56.821  128.146 1.00 36.31 ? 53  ASN L N   1 
ATOM   2016 C CA  . ASN B 2 60  ? 69.455  56.069  127.564 1.00 36.67 ? 53  ASN L CA  1 
ATOM   2017 C C   . ASN B 2 60  ? 70.718  56.895  127.599 1.00 38.02 ? 53  ASN L C   1 
ATOM   2018 O O   . ASN B 2 60  ? 70.784  57.999  127.060 1.00 32.81 ? 53  ASN L O   1 
ATOM   2019 C CB  . ASN B 2 60  ? 69.153  55.661  126.148 1.00 36.72 ? 53  ASN L CB  1 
ATOM   2020 C CG  . ASN B 2 60  ? 68.026  54.673  126.084 1.00 37.94 ? 53  ASN L CG  1 
ATOM   2021 O OD1 . ASN B 2 60  ? 66.858  55.044  126.150 1.00 38.97 ? 53  ASN L OD1 1 
ATOM   2022 N ND2 . ASN B 2 60  ? 68.367  53.404  125.986 1.00 39.96 ? 53  ASN L ND2 1 
ATOM   2023 N N   . ARG B 2 61  ? 71.715  56.363  128.278 1.00 41.74 ? 54  ARG L N   1 
ATOM   2024 C CA  . ARG B 2 61  ? 72.931  57.099  128.433 1.00 43.66 ? 54  ARG L CA  1 
ATOM   2025 C C   . ARG B 2 61  ? 73.836  56.720  127.309 1.00 43.98 ? 54  ARG L C   1 
ATOM   2026 O O   . ARG B 2 61  ? 74.121  55.547  127.042 1.00 41.87 ? 54  ARG L O   1 
ATOM   2027 C CB  . ARG B 2 61  ? 73.586  56.858  129.765 1.00 46.00 ? 54  ARG L CB  1 
ATOM   2028 C CG  . ARG B 2 61  ? 74.682  57.863  130.056 1.00 46.62 ? 54  ARG L CG  1 
ATOM   2029 C CD  . ARG B 2 61  ? 75.384  57.490  131.329 1.00 49.09 ? 54  ARG L CD  1 
ATOM   2030 N NE  . ARG B 2 61  ? 74.533  57.651  132.509 1.00 55.45 ? 54  ARG L NE  1 
ATOM   2031 C CZ  . ARG B 2 61  ? 73.788  56.705  133.095 1.00 60.88 ? 54  ARG L CZ  1 
ATOM   2032 N NH1 . ARG B 2 61  ? 73.729  55.457  132.624 1.00 66.55 ? 54  ARG L NH1 1 
ATOM   2033 N NH2 . ARG B 2 61  ? 73.071  57.016  134.175 1.00 60.74 ? 54  ARG L NH2 1 
ATOM   2034 N N   . PHE B 2 62  ? 74.303  57.764  126.668 1.00 47.47 ? 55  PHE L N   1 
ATOM   2035 C CA  . PHE B 2 62  ? 74.951  57.636  125.417 1.00 54.34 ? 55  PHE L CA  1 
ATOM   2036 C C   . PHE B 2 62  ? 76.355  57.044  125.675 1.00 54.79 ? 55  PHE L C   1 
ATOM   2037 O O   . PHE B 2 62  ? 77.015  57.383  126.668 1.00 51.82 ? 55  PHE L O   1 
ATOM   2038 C CB  . PHE B 2 62  ? 74.922  59.006  124.719 1.00 56.89 ? 55  PHE L CB  1 
ATOM   2039 C CG  . PHE B 2 62  ? 75.635  59.010  123.430 1.00 61.76 ? 55  PHE L CG  1 
ATOM   2040 C CD1 . PHE B 2 62  ? 75.277  58.097  122.451 1.00 62.34 ? 55  PHE L CD1 1 
ATOM   2041 C CD2 . PHE B 2 62  ? 76.705  59.877  123.211 1.00 62.87 ? 55  PHE L CD2 1 
ATOM   2042 C CE1 . PHE B 2 62  ? 75.961  58.050  121.273 1.00 65.79 ? 55  PHE L CE1 1 
ATOM   2043 C CE2 . PHE B 2 62  ? 77.397  59.843  122.024 1.00 65.51 ? 55  PHE L CE2 1 
ATOM   2044 C CZ  . PHE B 2 62  ? 77.033  58.925  121.055 1.00 67.64 ? 55  PHE L CZ  1 
ATOM   2045 N N   . SER B 2 63  ? 76.766  56.111  124.820 1.00 55.39 ? 56  SER L N   1 
ATOM   2046 C CA  . SER B 2 63  ? 77.950  55.280  125.077 1.00 54.34 ? 56  SER L CA  1 
ATOM   2047 C C   . SER B 2 63  ? 79.230  56.119  125.195 1.00 54.73 ? 56  SER L C   1 
ATOM   2048 O O   . SER B 2 63  ? 79.667  56.738  124.209 1.00 55.49 ? 56  SER L O   1 
ATOM   2049 C CB  . SER B 2 63  ? 78.106  54.230  123.972 1.00 57.22 ? 56  SER L CB  1 
ATOM   2050 O OG  . SER B 2 63  ? 79.099  53.267  124.302 1.00 58.03 ? 56  SER L OG  1 
ATOM   2051 N N   . GLY B 2 64  ? 79.813  56.132  126.401 1.00 50.14 ? 57  GLY L N   1 
ATOM   2052 C CA  . GLY B 2 64  ? 80.962  56.993  126.735 1.00 46.33 ? 57  GLY L CA  1 
ATOM   2053 C C   . GLY B 2 64  ? 80.650  58.258  127.534 1.00 46.38 ? 57  GLY L C   1 
ATOM   2054 O O   . GLY B 2 64  ? 81.562  59.028  127.844 1.00 47.89 ? 57  GLY L O   1 
ATOM   2055 N N   . VAL B 2 65  ? 79.378  58.482  127.866 1.00 40.37 ? 58  VAL L N   1 
ATOM   2056 C CA  . VAL B 2 65  ? 78.975  59.605  128.715 1.00 37.26 ? 58  VAL L CA  1 
ATOM   2057 C C   . VAL B 2 65  ? 79.037  59.140  130.165 1.00 35.96 ? 58  VAL L C   1 
ATOM   2058 O O   . VAL B 2 65  ? 78.472  58.107  130.480 1.00 35.18 ? 58  VAL L O   1 
ATOM   2059 C CB  . VAL B 2 65  ? 77.540  60.087  128.389 1.00 36.66 ? 58  VAL L CB  1 
ATOM   2060 C CG1 . VAL B 2 65  ? 77.042  61.138  129.379 1.00 35.78 ? 58  VAL L CG1 1 
ATOM   2061 C CG2 . VAL B 2 65  ? 77.492  60.651  126.982 1.00 36.26 ? 58  VAL L CG2 1 
ATOM   2062 N N   . PRO B 2 66  ? 79.689  59.920  131.054 1.00 36.22 ? 59  PRO L N   1 
ATOM   2063 C CA  . PRO B 2 66  ? 79.827  59.524  132.463 1.00 37.77 ? 59  PRO L CA  1 
ATOM   2064 C C   . PRO B 2 66  ? 78.509  59.208  133.130 1.00 38.21 ? 59  PRO L C   1 
ATOM   2065 O O   . PRO B 2 66  ? 77.508  59.866  132.857 1.00 41.92 ? 59  PRO L O   1 
ATOM   2066 C CB  . PRO B 2 66  ? 80.444  60.763  133.133 1.00 36.82 ? 59  PRO L CB  1 
ATOM   2067 C CG  . PRO B 2 66  ? 81.103  61.518  132.038 1.00 36.77 ? 59  PRO L CG  1 
ATOM   2068 C CD  . PRO B 2 66  ? 80.342  61.217  130.781 1.00 36.61 ? 59  PRO L CD  1 
ATOM   2069 N N   . ASP B 2 67  ? 78.527  58.232  134.026 1.00 38.54 ? 60  ASP L N   1 
ATOM   2070 C CA  . ASP B 2 67  ? 77.315  57.823  134.745 1.00 38.48 ? 60  ASP L CA  1 
ATOM   2071 C C   . ASP B 2 67  ? 76.810  58.850  135.755 1.00 34.45 ? 60  ASP L C   1 
ATOM   2072 O O   . ASP B 2 67  ? 75.737  58.678  136.326 1.00 32.47 ? 60  ASP L O   1 
ATOM   2073 C CB  . ASP B 2 67  ? 77.466  56.431  135.408 1.00 42.13 ? 60  ASP L CB  1 
ATOM   2074 C CG  . ASP B 2 67  ? 78.681  56.320  136.340 1.00 46.69 ? 60  ASP L CG  1 
ATOM   2075 O OD1 . ASP B 2 67  ? 79.148  57.344  136.900 1.00 47.83 ? 60  ASP L OD1 1 
ATOM   2076 O OD2 . ASP B 2 67  ? 79.175  55.178  136.507 1.00 50.48 ? 60  ASP L OD2 1 
ATOM   2077 N N   . ARG B 2 68  ? 77.578  59.912  135.980 1.00 33.60 ? 61  ARG L N   1 
ATOM   2078 C CA  . ARG B 2 68  ? 77.111  61.035  136.788 1.00 34.26 ? 61  ARG L CA  1 
ATOM   2079 C C   . ARG B 2 68  ? 75.871  61.701  136.208 1.00 31.50 ? 61  ARG L C   1 
ATOM   2080 O O   . ARG B 2 68  ? 75.130  62.327  136.949 1.00 31.23 ? 61  ARG L O   1 
ATOM   2081 C CB  . ARG B 2 68  ? 78.195  62.098  136.904 1.00 36.12 ? 61  ARG L CB  1 
ATOM   2082 C CG  . ARG B 2 68  ? 79.401  61.649  137.693 1.00 37.99 ? 61  ARG L CG  1 
ATOM   2083 C CD  . ARG B 2 68  ? 80.400  62.770  137.824 1.00 37.96 ? 61  ARG L CD  1 
ATOM   2084 N NE  . ARG B 2 68  ? 81.017  63.110  136.530 1.00 38.90 ? 61  ARG L NE  1 
ATOM   2085 C CZ  . ARG B 2 68  ? 80.823  64.248  135.857 1.00 38.10 ? 61  ARG L CZ  1 
ATOM   2086 N NH1 . ARG B 2 68  ? 80.013  65.194  136.331 1.00 36.38 ? 61  ARG L NH1 1 
ATOM   2087 N NH2 . ARG B 2 68  ? 81.453  64.443  134.699 1.00 38.38 ? 61  ARG L NH2 1 
ATOM   2088 N N   . PHE B 2 69  ? 75.701  61.609  134.883 1.00 28.76 ? 62  PHE L N   1 
ATOM   2089 C CA  . PHE B 2 69  ? 74.536  62.154  134.190 1.00 27.33 ? 62  PHE L CA  1 
ATOM   2090 C C   . PHE B 2 69  ? 73.436  61.126  134.177 1.00 27.76 ? 62  PHE L C   1 
ATOM   2091 O O   . PHE B 2 69  ? 73.657  59.987  133.769 1.00 27.95 ? 62  PHE L O   1 
ATOM   2092 C CB  . PHE B 2 69  ? 74.894  62.525  132.756 1.00 26.33 ? 62  PHE L CB  1 
ATOM   2093 C CG  . PHE B 2 69  ? 75.906  63.630  132.654 1.00 26.67 ? 62  PHE L CG  1 
ATOM   2094 C CD1 . PHE B 2 69  ? 75.516  64.965  132.781 1.00 26.35 ? 62  PHE L CD1 1 
ATOM   2095 C CD2 . PHE B 2 69  ? 77.256  63.344  132.434 1.00 26.97 ? 62  PHE L CD2 1 
ATOM   2096 C CE1 . PHE B 2 69  ? 76.448  65.993  132.683 1.00 25.96 ? 62  PHE L CE1 1 
ATOM   2097 C CE2 . PHE B 2 69  ? 78.192  64.367  132.326 1.00 27.17 ? 62  PHE L CE2 1 
ATOM   2098 C CZ  . PHE B 2 69  ? 77.783  65.697  132.451 1.00 27.14 ? 62  PHE L CZ  1 
ATOM   2099 N N   . SER B 2 70  ? 72.253  61.520  134.628 1.00 27.64 ? 63  SER L N   1 
ATOM   2100 C CA  . SER B 2 70  ? 71.103  60.649  134.565 1.00 27.97 ? 63  SER L CA  1 
ATOM   2101 C C   . SER B 2 70  ? 69.863  61.433  134.162 1.00 26.79 ? 63  SER L C   1 
ATOM   2102 O O   . SER B 2 70  ? 69.639  62.553  134.603 1.00 24.62 ? 63  SER L O   1 
ATOM   2103 C CB  . SER B 2 70  ? 70.888  59.925  135.895 1.00 28.52 ? 63  SER L CB  1 
ATOM   2104 O OG  . SER B 2 70  ? 70.618  60.829  136.942 1.00 31.26 ? 63  SER L OG  1 
ATOM   2105 N N   . GLY B 2 71  ? 69.061  60.816  133.311 1.00 26.27 ? 64  GLY L N   1 
ATOM   2106 C CA  . GLY B 2 71  ? 67.842  61.435  132.823 1.00 26.17 ? 64  GLY L CA  1 
ATOM   2107 C C   . GLY B 2 71  ? 66.649  60.686  133.335 1.00 25.38 ? 64  GLY L C   1 
ATOM   2108 O O   . GLY B 2 71  ? 66.632  59.468  133.301 1.00 24.39 ? 64  GLY L O   1 
ATOM   2109 N N   . SER B 2 72  ? 65.644  61.420  133.796 1.00 26.62 ? 65  SER L N   1 
ATOM   2110 C CA  . SER B 2 72  ? 64.412  60.818  134.266 1.00 27.75 ? 65  SER L CA  1 
ATOM   2111 C C   . SER B 2 72  ? 63.198  61.626  133.838 1.00 29.75 ? 65  SER L C   1 
ATOM   2112 O O   . SER B 2 72  ? 63.310  62.723  133.283 1.00 29.28 ? 65  SER L O   1 
ATOM   2113 C CB  . SER B 2 72  ? 64.433  60.718  135.802 1.00 28.31 ? 65  SER L CB  1 
ATOM   2114 O OG  . SER B 2 72  ? 64.391  62.011  136.385 1.00 28.94 ? 65  SER L OG  1 
ATOM   2115 N N   . GLY B 2 73  ? 62.036  61.057  134.150 1.00 30.80 ? 66  GLY L N   1 
ATOM   2116 C CA  . GLY B 2 73  ? 60.754  61.749  134.107 1.00 32.50 ? 66  GLY L CA  1 
ATOM   2117 C C   . GLY B 2 73  ? 59.838  61.004  133.172 1.00 34.18 ? 66  GLY L C   1 
ATOM   2118 O O   . GLY B 2 73  ? 60.179  59.916  132.680 1.00 31.65 ? 66  GLY L O   1 
ATOM   2119 N N   . SER B 2 74  ? 58.669  61.572  132.919 1.00 36.62 ? 67  SER L N   1 
ATOM   2120 C CA  . SER B 2 74  ? 57.818  61.042  131.844 1.00 39.51 ? 67  SER L CA  1 
ATOM   2121 C C   . SER B 2 74  ? 56.712  61.978  131.401 1.00 39.32 ? 67  SER L C   1 
ATOM   2122 O O   . SER B 2 74  ? 56.337  62.928  132.104 1.00 39.88 ? 67  SER L O   1 
ATOM   2123 C CB  . SER B 2 74  ? 57.182  59.704  132.237 1.00 40.03 ? 67  SER L CB  1 
ATOM   2124 O OG  . SER B 2 74  ? 56.114  59.933  133.131 1.00 41.33 ? 67  SER L OG  1 
ATOM   2125 N N   . GLY B 2 75  ? 56.187  61.652  130.222 1.00 39.56 ? 68  GLY L N   1 
ATOM   2126 C CA  . GLY B 2 75  ? 55.037  62.329  129.633 1.00 37.23 ? 68  GLY L CA  1 
ATOM   2127 C C   . GLY B 2 75  ? 55.405  63.705  129.122 1.00 34.45 ? 68  GLY L C   1 
ATOM   2128 O O   . GLY B 2 75  ? 55.624  63.896  127.920 1.00 35.56 ? 68  GLY L O   1 
ATOM   2129 N N   . THR B 2 76  ? 55.432  64.659  130.048 1.00 31.16 ? 69  THR L N   1 
ATOM   2130 C CA  . THR B 2 76  ? 55.810  66.060  129.767 1.00 28.68 ? 69  THR L CA  1 
ATOM   2131 C C   . THR B 2 76  ? 56.772  66.707  130.775 1.00 26.78 ? 69  THR L C   1 
ATOM   2132 O O   . THR B 2 76  ? 57.124  67.857  130.604 1.00 23.94 ? 69  THR L O   1 
ATOM   2133 C CB  . THR B 2 76  ? 54.568  66.968  129.709 1.00 27.56 ? 69  THR L CB  1 
ATOM   2134 O OG1 . THR B 2 76  ? 53.910  66.937  130.967 1.00 27.83 ? 69  THR L OG1 1 
ATOM   2135 C CG2 . THR B 2 76  ? 53.604  66.520  128.641 1.00 27.77 ? 69  THR L CG2 1 
ATOM   2136 N N   . ASP B 2 77  ? 57.167  65.984  131.819 1.00 28.55 ? 70  ASP L N   1 
ATOM   2137 C CA  . ASP B 2 77  ? 58.071  66.502  132.847 1.00 31.24 ? 70  ASP L CA  1 
ATOM   2138 C C   . ASP B 2 77  ? 59.342  65.660  132.957 1.00 27.57 ? 70  ASP L C   1 
ATOM   2139 O O   . ASP B 2 77  ? 59.295  64.481  133.301 1.00 29.52 ? 70  ASP L O   1 
ATOM   2140 C CB  . ASP B 2 77  ? 57.379  66.572  134.201 1.00 35.55 ? 70  ASP L CB  1 
ATOM   2141 C CG  . ASP B 2 77  ? 57.957  67.659  135.067 1.00 38.90 ? 70  ASP L CG  1 
ATOM   2142 O OD1 . ASP B 2 77  ? 57.682  68.840  134.784 1.00 44.59 ? 70  ASP L OD1 1 
ATOM   2143 O OD2 . ASP B 2 77  ? 58.704  67.349  135.999 1.00 44.59 ? 70  ASP L OD2 1 
ATOM   2144 N N   . PHE B 2 78  ? 60.470  66.280  132.654 1.00 24.19 ? 71  PHE L N   1 
ATOM   2145 C CA  . PHE B 2 78  ? 61.736  65.580  132.507 1.00 22.32 ? 71  PHE L CA  1 
ATOM   2146 C C   . PHE B 2 78  ? 62.787  66.303  133.306 1.00 21.60 ? 71  PHE L C   1 
ATOM   2147 O O   . PHE B 2 78  ? 62.683  67.503  133.523 1.00 19.75 ? 71  PHE L O   1 
ATOM   2148 C CB  . PHE B 2 78  ? 62.105  65.532  131.035 1.00 22.09 ? 71  PHE L CB  1 
ATOM   2149 C CG  . PHE B 2 78  ? 61.010  64.985  130.186 1.00 20.75 ? 71  PHE L CG  1 
ATOM   2150 C CD1 . PHE B 2 78  ? 60.784  63.613  130.127 1.00 20.78 ? 71  PHE L CD1 1 
ATOM   2151 C CD2 . PHE B 2 78  ? 60.152  65.842  129.512 1.00 20.78 ? 71  PHE L CD2 1 
ATOM   2152 C CE1 . PHE B 2 78  ? 59.731  63.102  129.380 1.00 20.99 ? 71  PHE L CE1 1 
ATOM   2153 C CE2 . PHE B 2 78  ? 59.108  65.347  128.762 1.00 20.76 ? 71  PHE L CE2 1 
ATOM   2154 C CZ  . PHE B 2 78  ? 58.894  63.973  128.701 1.00 21.53 ? 71  PHE L CZ  1 
ATOM   2155 N N   . THR B 2 79  ? 63.778  65.550  133.774 1.00 21.39 ? 72  THR L N   1 
ATOM   2156 C CA  . THR B 2 79  ? 64.814  66.104  134.625 1.00 21.22 ? 72  THR L CA  1 
ATOM   2157 C C   . THR B 2 79  ? 66.128  65.478  134.246 1.00 21.20 ? 72  THR L C   1 
ATOM   2158 O O   . THR B 2 79  ? 66.220  64.277  134.002 1.00 20.80 ? 72  THR L O   1 
ATOM   2159 C CB  . THR B 2 79  ? 64.489  65.894  136.124 1.00 21.15 ? 72  THR L CB  1 
ATOM   2160 O OG1 . THR B 2 79  ? 63.229  66.497  136.423 1.00 21.46 ? 72  THR L OG1 1 
ATOM   2161 C CG2 . THR B 2 79  ? 65.537  66.523  137.032 1.00 20.27 ? 72  THR L CG2 1 
ATOM   2162 N N   . LEU B 2 80  ? 67.140  66.325  134.156 1.00 22.57 ? 73  LEU L N   1 
ATOM   2163 C CA  . LEU B 2 80  ? 68.515  65.876  134.047 1.00 24.10 ? 73  LEU L CA  1 
ATOM   2164 C C   . LEU B 2 80  ? 69.217  66.090  135.383 1.00 24.64 ? 73  LEU L C   1 
ATOM   2165 O O   . LEU B 2 80  ? 69.207  67.206  135.907 1.00 23.87 ? 73  LEU L O   1 
ATOM   2166 C CB  . LEU B 2 80  ? 69.245  66.667  132.965 1.00 23.92 ? 73  LEU L CB  1 
ATOM   2167 C CG  . LEU B 2 80  ? 70.677  66.205  132.702 1.00 23.83 ? 73  LEU L CG  1 
ATOM   2168 C CD1 . LEU B 2 80  ? 70.657  64.859  131.990 1.00 24.27 ? 73  LEU L CD1 1 
ATOM   2169 C CD2 . LEU B 2 80  ? 71.475  67.233  131.904 1.00 23.74 ? 73  LEU L CD2 1 
ATOM   2170 N N   . LYS B 2 81  ? 69.836  65.030  135.907 1.00 26.14 ? 74  LYS L N   1 
ATOM   2171 C CA  . LYS B 2 81  ? 70.646  65.119  137.136 1.00 29.23 ? 74  LYS L CA  1 
ATOM   2172 C C   . LYS B 2 81  ? 72.112  64.855  136.885 1.00 28.75 ? 74  LYS L C   1 
ATOM   2173 O O   . LYS B 2 81  ? 72.454  63.975  136.111 1.00 26.28 ? 74  LYS L O   1 
ATOM   2174 C CB  . LYS B 2 81  ? 70.151  64.152  138.198 1.00 31.65 ? 74  LYS L CB  1 
ATOM   2175 C CG  . LYS B 2 81  ? 68.904  64.668  138.851 1.00 34.84 ? 74  LYS L CG  1 
ATOM   2176 C CD  . LYS B 2 81  ? 68.490  63.872  140.075 1.00 38.56 ? 74  LYS L CD  1 
ATOM   2177 C CE  . LYS B 2 81  ? 67.069  64.243  140.494 1.00 39.56 ? 74  LYS L CE  1 
ATOM   2178 N NZ  . LYS B 2 81  ? 66.848  65.704  140.682 1.00 40.89 ? 74  LYS L NZ  1 
ATOM   2179 N N   . ILE B 2 82  ? 72.950  65.643  137.561 1.00 28.94 ? 75  ILE L N   1 
ATOM   2180 C CA  . ILE B 2 82  ? 74.405  65.562  137.478 1.00 31.61 ? 75  ILE L CA  1 
ATOM   2181 C C   . ILE B 2 82  ? 74.901  65.433  138.917 1.00 35.57 ? 75  ILE L C   1 
ATOM   2182 O O   . ILE B 2 82  ? 74.777  66.360  139.721 1.00 36.07 ? 75  ILE L O   1 
ATOM   2183 C CB  . ILE B 2 82  ? 75.037  66.808  136.820 1.00 31.39 ? 75  ILE L CB  1 
ATOM   2184 C CG1 . ILE B 2 82  ? 74.251  67.210  135.559 1.00 32.06 ? 75  ILE L CG1 1 
ATOM   2185 C CG2 . ILE B 2 82  ? 76.506  66.530  136.506 1.00 31.26 ? 75  ILE L CG2 1 
ATOM   2186 C CD1 . ILE B 2 82  ? 74.623  68.562  134.992 1.00 32.04 ? 75  ILE L CD1 1 
ATOM   2187 N N   . SER B 2 83  ? 75.461  64.280  139.253 1.00 39.86 ? 76  SER L N   1 
ATOM   2188 C CA  . SER B 2 83  ? 75.626  63.938  140.671 1.00 40.09 ? 76  SER L CA  1 
ATOM   2189 C C   . SER B 2 83  ? 76.838  64.598  141.346 1.00 41.79 ? 76  SER L C   1 
ATOM   2190 O O   . SER B 2 83  ? 76.782  64.879  142.551 1.00 46.56 ? 76  SER L O   1 
ATOM   2191 C CB  . SER B 2 83  ? 75.620  62.426  140.862 1.00 38.81 ? 76  SER L CB  1 
ATOM   2192 O OG  . SER B 2 83  ? 76.625  61.827  140.075 1.00 40.93 ? 76  SER L OG  1 
ATOM   2193 N N   . ARG B 2 84  ? 77.903  64.889  140.603 1.00 39.00 ? 77  ARG L N   1 
ATOM   2194 C CA  . ARG B 2 84  ? 79.067  65.560  141.203 1.00 39.09 ? 77  ARG L CA  1 
ATOM   2195 C C   . ARG B 2 84  ? 79.704  66.442  140.168 1.00 36.18 ? 77  ARG L C   1 
ATOM   2196 O O   . ARG B 2 84  ? 80.624  66.034  139.482 1.00 36.28 ? 77  ARG L O   1 
ATOM   2197 C CB  . ARG B 2 84  ? 80.079  64.543  141.751 1.00 42.42 ? 77  ARG L CB  1 
ATOM   2198 C CG  . ARG B 2 84  ? 79.771  64.065  143.174 1.00 45.99 ? 77  ARG L CG  1 
ATOM   2199 C CD  . ARG B 2 84  ? 80.722  62.980  143.687 1.00 49.83 ? 77  ARG L CD  1 
ATOM   2200 N NE  . ARG B 2 84  ? 81.218  62.117  142.607 1.00 53.19 ? 77  ARG L NE  1 
ATOM   2201 C CZ  . ARG B 2 84  ? 80.501  61.195  141.952 1.00 53.31 ? 77  ARG L CZ  1 
ATOM   2202 N NH1 . ARG B 2 84  ? 79.218  60.963  142.248 1.00 53.02 ? 77  ARG L NH1 1 
ATOM   2203 N NH2 . ARG B 2 84  ? 81.080  60.501  140.975 1.00 53.39 ? 77  ARG L NH2 1 
ATOM   2204 N N   . VAL B 2 85  ? 79.201  67.666  140.080 1.00 35.68 ? 78  VAL L N   1 
ATOM   2205 C CA  . VAL B 2 85  ? 79.526  68.571  138.994 1.00 33.94 ? 78  VAL L CA  1 
ATOM   2206 C C   . VAL B 2 85  ? 81.009  68.855  138.957 1.00 34.07 ? 78  VAL L C   1 
ATOM   2207 O O   . VAL B 2 85  ? 81.598  69.182  139.976 1.00 35.52 ? 78  VAL L O   1 
ATOM   2208 C CB  . VAL B 2 85  ? 78.770  69.912  139.136 1.00 33.05 ? 78  VAL L CB  1 
ATOM   2209 C CG1 . VAL B 2 85  ? 79.333  70.972  138.191 1.00 32.40 ? 78  VAL L CG1 1 
ATOM   2210 C CG2 . VAL B 2 85  ? 77.287  69.704  138.867 1.00 33.01 ? 78  VAL L CG2 1 
ATOM   2211 N N   . GLU B 2 86  ? 81.586  68.767  137.767 1.00 34.72 ? 79  GLU L N   1 
ATOM   2212 C CA  . GLU B 2 86  ? 82.969  69.149  137.545 1.00 35.89 ? 79  GLU L CA  1 
ATOM   2213 C C   . GLU B 2 86  ? 83.138  70.105  136.361 1.00 35.13 ? 79  GLU L C   1 
ATOM   2214 O O   . GLU B 2 86  ? 82.227  70.296  135.542 1.00 34.40 ? 79  GLU L O   1 
ATOM   2215 C CB  . GLU B 2 86  ? 83.842  67.902  137.395 1.00 37.43 ? 79  GLU L CB  1 
ATOM   2216 C CG  . GLU B 2 86  ? 83.419  66.929  136.328 1.00 37.51 ? 79  GLU L CG  1 
ATOM   2217 C CD  . GLU B 2 86  ? 84.233  65.648  136.390 1.00 38.13 ? 79  GLU L CD  1 
ATOM   2218 O OE1 . GLU B 2 86  ? 84.011  64.821  137.303 1.00 35.16 ? 79  GLU L OE1 1 
ATOM   2219 O OE2 . GLU B 2 86  ? 85.087  65.466  135.507 1.00 39.76 ? 79  GLU L OE2 1 
ATOM   2220 N N   . ALA B 2 87  ? 84.324  70.698  136.295 1.00 33.52 ? 80  ALA L N   1 
ATOM   2221 C CA  . ALA B 2 87  ? 84.695  71.691  135.283 1.00 33.59 ? 80  ALA L CA  1 
ATOM   2222 C C   . ALA B 2 87  ? 84.216  71.358  133.858 1.00 33.33 ? 80  ALA L C   1 
ATOM   2223 O O   . ALA B 2 87  ? 83.741  72.231  133.130 1.00 33.21 ? 80  ALA L O   1 
ATOM   2224 C CB  . ALA B 2 87  ? 86.206  71.871  135.285 1.00 33.98 ? 80  ALA L CB  1 
ATOM   2225 N N   . ALA B 2 88  ? 84.343  70.086  133.490 1.00 31.97 ? 81  ALA L N   1 
ATOM   2226 C CA  . ALA B 2 88  ? 83.961  69.583  132.175 1.00 30.91 ? 81  ALA L CA  1 
ATOM   2227 C C   . ALA B 2 88  ? 82.460  69.652  131.854 1.00 28.33 ? 81  ALA L C   1 
ATOM   2228 O O   . ALA B 2 88  ? 82.078  69.584  130.685 1.00 30.63 ? 81  ALA L O   1 
ATOM   2229 C CB  . ALA B 2 88  ? 84.448  68.149  132.032 1.00 30.75 ? 81  ALA L CB  1 
ATOM   2230 N N   . ASP B 2 89  ? 81.636  69.782  132.885 1.00 26.46 ? 82  ASP L N   1 
ATOM   2231 C CA  . ASP B 2 89  ? 80.180  69.809  132.771 1.00 26.22 ? 82  ASP L CA  1 
ATOM   2232 C C   . ASP B 2 89  ? 79.592  71.203  132.587 1.00 26.67 ? 82  ASP L C   1 
ATOM   2233 O O   . ASP B 2 89  ? 78.376  71.340  132.342 1.00 26.44 ? 82  ASP L O   1 
ATOM   2234 C CB  . ASP B 2 89  ? 79.542  69.244  134.043 1.00 25.59 ? 82  ASP L CB  1 
ATOM   2235 C CG  . ASP B 2 89  ? 80.110  67.906  134.446 1.00 25.09 ? 82  ASP L CG  1 
ATOM   2236 O OD1 . ASP B 2 89  ? 80.650  67.186  133.578 1.00 23.37 ? 82  ASP L OD1 1 
ATOM   2237 O OD2 . ASP B 2 89  ? 80.006  67.591  135.659 1.00 23.40 ? 82  ASP L OD2 1 
ATOM   2238 N N   . LEU B 2 90  ? 80.422  72.229  132.734 1.00 24.43 ? 83  LEU L N   1 
ATOM   2239 C CA  . LEU B 2 90  ? 79.953  73.592  132.604 1.00 25.14 ? 83  LEU L CA  1 
ATOM   2240 C C   . LEU B 2 90  ? 79.643  73.963  131.148 1.00 22.95 ? 83  LEU L C   1 
ATOM   2241 O O   . LEU B 2 90  ? 80.362  73.596  130.233 1.00 21.80 ? 83  LEU L O   1 
ATOM   2242 C CB  . LEU B 2 90  ? 80.980  74.572  133.163 1.00 26.57 ? 83  LEU L CB  1 
ATOM   2243 C CG  . LEU B 2 90  ? 81.333  74.386  134.636 1.00 28.10 ? 83  LEU L CG  1 
ATOM   2244 C CD1 . LEU B 2 90  ? 82.442  75.369  134.973 1.00 28.14 ? 83  LEU L CD1 1 
ATOM   2245 C CD2 . LEU B 2 90  ? 80.127  74.535  135.564 1.00 27.64 ? 83  LEU L CD2 1 
ATOM   2246 N N   . GLY B 2 91  ? 78.579  74.729  130.969 1.00 20.56 ? 84  GLY L N   1 
ATOM   2247 C CA  . GLY B 2 91  ? 78.096  75.106  129.642 1.00 19.82 ? 84  GLY L CA  1 
ATOM   2248 C C   . GLY B 2 91  ? 76.579  75.219  129.650 1.00 18.88 ? 84  GLY L C   1 
ATOM   2249 O O   . GLY B 2 91  ? 75.961  75.321  130.715 1.00 17.85 ? 84  GLY L O   1 
ATOM   2250 N N   . ILE B 2 92  ? 75.982  75.189  128.457 1.00 18.19 ? 85  ILE L N   1 
ATOM   2251 C CA  . ILE B 2 92  ? 74.527  75.245  128.313 1.00 17.57 ? 85  ILE L CA  1 
ATOM   2252 C C   . ILE B 2 92  ? 73.943  73.866  128.004 1.00 16.48 ? 85  ILE L C   1 
ATOM   2253 O O   . ILE B 2 92  ? 74.345  73.201  127.054 1.00 16.07 ? 85  ILE L O   1 
ATOM   2254 C CB  . ILE B 2 92  ? 74.091  76.248  127.229 1.00 18.37 ? 85  ILE L CB  1 
ATOM   2255 C CG1 . ILE B 2 92  ? 74.850  77.572  127.352 1.00 19.35 ? 85  ILE L CG1 1 
ATOM   2256 C CG2 . ILE B 2 92  ? 72.583  76.503  127.273 1.00 17.52 ? 85  ILE L CG2 1 
ATOM   2257 C CD1 . ILE B 2 92  ? 74.666  78.257  128.675 1.00 20.65 ? 85  ILE L CD1 1 
ATOM   2258 N N   . TYR B 2 93  ? 72.972  73.480  128.822 1.00 15.95 ? 86  TYR L N   1 
ATOM   2259 C CA  . TYR B 2 93  ? 72.229  72.235  128.677 1.00 16.43 ? 86  TYR L CA  1 
ATOM   2260 C C   . TYR B 2 93  ? 70.907  72.500  127.964 1.00 16.11 ? 86  TYR L C   1 
ATOM   2261 O O   . TYR B 2 93  ? 70.147  73.379  128.383 1.00 15.32 ? 86  TYR L O   1 
ATOM   2262 C CB  . TYR B 2 93  ? 71.949  71.591  130.047 1.00 16.56 ? 86  TYR L CB  1 
ATOM   2263 C CG  . TYR B 2 93  ? 73.187  71.011  130.659 1.00 16.89 ? 86  TYR L CG  1 
ATOM   2264 C CD1 . TYR B 2 93  ? 74.096  71.827  131.350 1.00 17.55 ? 86  TYR L CD1 1 
ATOM   2265 C CD2 . TYR B 2 93  ? 73.492  69.665  130.513 1.00 16.88 ? 86  TYR L CD2 1 
ATOM   2266 C CE1 . TYR B 2 93  ? 75.275  71.309  131.883 1.00 16.97 ? 86  TYR L CE1 1 
ATOM   2267 C CE2 . TYR B 2 93  ? 74.666  69.135  131.058 1.00 17.58 ? 86  TYR L CE2 1 
ATOM   2268 C CZ  . TYR B 2 93  ? 75.546  69.964  131.740 1.00 17.45 ? 86  TYR L CZ  1 
ATOM   2269 O OH  . TYR B 2 93  ? 76.708  69.433  132.248 1.00 18.94 ? 86  TYR L OH  1 
ATOM   2270 N N   . PHE B 2 94  ? 70.651  71.720  126.911 1.00 15.49 ? 87  PHE L N   1 
ATOM   2271 C CA  . PHE B 2 94  ? 69.435  71.826  126.108 1.00 14.92 ? 87  PHE L CA  1 
ATOM   2272 C C   . PHE B 2 94  ? 68.689  70.508  126.152 1.00 15.17 ? 87  PHE L C   1 
ATOM   2273 O O   . PHE B 2 94  ? 69.304  69.424  126.049 1.00 15.41 ? 87  PHE L O   1 
ATOM   2274 C CB  . PHE B 2 94  ? 69.774  72.103  124.650 1.00 14.53 ? 87  PHE L CB  1 
ATOM   2275 C CG  . PHE B 2 94  ? 70.461  73.426  124.405 1.00 15.01 ? 87  PHE L CG  1 
ATOM   2276 C CD1 . PHE B 2 94  ? 69.721  74.603  124.279 1.00 14.90 ? 87  PHE L CD1 1 
ATOM   2277 C CD2 . PHE B 2 94  ? 71.846  73.489  124.228 1.00 15.07 ? 87  PHE L CD2 1 
ATOM   2278 C CE1 . PHE B 2 94  ? 70.344  75.814  124.012 1.00 14.59 ? 87  PHE L CE1 1 
ATOM   2279 C CE2 . PHE B 2 94  ? 72.471  74.700  123.970 1.00 14.87 ? 87  PHE L CE2 1 
ATOM   2280 C CZ  . PHE B 2 94  ? 71.715  75.865  123.864 1.00 14.89 ? 87  PHE L CZ  1 
ATOM   2281 N N   . CYS B 2 95  ? 67.373  70.580  126.301 1.00 14.56 ? 88  CYS L N   1 
ATOM   2282 C CA  . CYS B 2 95  ? 66.530  69.431  125.974 1.00 14.69 ? 88  CYS L CA  1 
ATOM   2283 C C   . CYS B 2 95  ? 66.015  69.597  124.535 1.00 14.43 ? 88  CYS L C   1 
ATOM   2284 O O   . CYS B 2 95  ? 66.001  70.708  123.988 1.00 15.66 ? 88  CYS L O   1 
ATOM   2285 C CB  . CYS B 2 95  ? 65.392  69.272  126.980 1.00 14.92 ? 88  CYS L CB  1 
ATOM   2286 S SG  . CYS B 2 95  ? 64.295  70.705  127.115 1.00 15.72 ? 88  CYS L SG  1 
ATOM   2287 N N   . SER B 2 96  ? 65.630  68.501  123.909 1.00 14.44 ? 89  SER L N   1 
ATOM   2288 C CA  . SER B 2 96  ? 64.987  68.555  122.596 1.00 15.17 ? 89  SER L CA  1 
ATOM   2289 C C   . SER B 2 96  ? 64.035  67.406  122.485 1.00 15.90 ? 89  SER L C   1 
ATOM   2290 O O   . SER B 2 96  ? 64.171  66.403  123.234 1.00 17.61 ? 89  SER L O   1 
ATOM   2291 C CB  . SER B 2 96  ? 65.996  68.482  121.447 1.00 15.68 ? 89  SER L CB  1 
ATOM   2292 O OG  . SER B 2 96  ? 66.578  67.198  121.365 1.00 15.63 ? 89  SER L OG  1 
ATOM   2293 N N   . GLN B 2 97  ? 63.092  67.530  121.551 1.00 14.94 ? 90  GLN L N   1 
ATOM   2294 C CA  . GLN B 2 97  ? 62.144  66.449  121.281 1.00 15.02 ? 90  GLN L CA  1 
ATOM   2295 C C   . GLN B 2 97  ? 62.086  66.110  119.805 1.00 15.08 ? 90  GLN L C   1 
ATOM   2296 O O   . GLN B 2 97  ? 62.050  66.989  118.947 1.00 14.54 ? 90  GLN L O   1 
ATOM   2297 C CB  . GLN B 2 97  ? 60.751  66.760  121.843 1.00 14.69 ? 90  GLN L CB  1 
ATOM   2298 C CG  . GLN B 2 97  ? 59.944  67.823  121.104 1.00 14.80 ? 90  GLN L CG  1 
ATOM   2299 C CD  . GLN B 2 97  ? 59.254  67.306  119.833 1.00 14.90 ? 90  GLN L CD  1 
ATOM   2300 O OE1 . GLN B 2 97  ? 59.020  66.109  119.674 1.00 14.58 ? 90  GLN L OE1 1 
ATOM   2301 N NE2 . GLN B 2 97  ? 58.964  68.215  118.914 1.00 14.89 ? 90  GLN L NE2 1 
ATOM   2302 N N   . THR B 2 98  ? 62.098  64.812  119.528 1.00 16.08 ? 91  THR L N   1 
ATOM   2303 C CA  . THR B 2 98  ? 61.957  64.301  118.182 1.00 16.15 ? 91  THR L CA  1 
ATOM   2304 C C   . THR B 2 98  ? 60.763  63.324  118.080 1.00 16.88 ? 91  THR L C   1 
ATOM   2305 O O   . THR B 2 98  ? 60.722  62.439  117.230 1.00 17.12 ? 91  THR L O   1 
ATOM   2306 C CB  . THR B 2 98  ? 63.266  63.647  117.750 1.00 15.85 ? 91  THR L CB  1 
ATOM   2307 O OG1 . THR B 2 98  ? 63.515  62.525  118.588 1.00 15.28 ? 91  THR L OG1 1 
ATOM   2308 C CG2 . THR B 2 98  ? 64.442  64.650  117.857 1.00 15.47 ? 91  THR L CG2 1 
ATOM   2309 N N   . THR B 2 99  ? 59.789  63.477  118.961 1.00 17.64 ? 92  THR L N   1 
ATOM   2310 C CA  . THR B 2 99  ? 58.578  62.670  118.854 1.00 18.54 ? 92  THR L CA  1 
ATOM   2311 C C   . THR B 2 99  ? 57.669  63.205  117.734 1.00 18.39 ? 92  THR L C   1 
ATOM   2312 O O   . THR B 2 99  ? 57.096  62.423  116.984 1.00 18.19 ? 92  THR L O   1 
ATOM   2313 C CB  . THR B 2 99  ? 57.798  62.610  120.179 1.00 18.64 ? 92  THR L CB  1 
ATOM   2314 O OG1 . THR B 2 99  ? 58.632  62.068  121.212 1.00 17.90 ? 92  THR L OG1 1 
ATOM   2315 C CG2 . THR B 2 99  ? 56.535  61.715  120.027 1.00 19.69 ? 92  THR L CG2 1 
ATOM   2316 N N   . HIS B 2 100 ? 57.531  64.524  117.647 1.00 18.47 ? 93  HIS L N   1 
ATOM   2317 C CA  . HIS B 2 100 ? 56.577  65.143  116.742 1.00 18.87 ? 93  HIS L CA  1 
ATOM   2318 C C   . HIS B 2 100 ? 57.305  66.100  115.831 1.00 19.33 ? 93  HIS L C   1 
ATOM   2319 O O   . HIS B 2 100 ? 58.127  66.901  116.285 1.00 20.31 ? 93  HIS L O   1 
ATOM   2320 C CB  . HIS B 2 100 ? 55.520  65.918  117.533 1.00 19.52 ? 93  HIS L CB  1 
ATOM   2321 C CG  . HIS B 2 100 ? 54.816  65.101  118.574 1.00 19.68 ? 93  HIS L CG  1 
ATOM   2322 N ND1 . HIS B 2 100 ? 53.845  64.180  118.255 1.00 19.23 ? 93  HIS L ND1 1 
ATOM   2323 C CD2 . HIS B 2 100 ? 54.943  65.064  119.926 1.00 20.01 ? 93  HIS L CD2 1 
ATOM   2324 C CE1 . HIS B 2 100 ? 53.396  63.619  119.364 1.00 19.61 ? 93  HIS L CE1 1 
ATOM   2325 N NE2 . HIS B 2 100 ? 54.032  64.152  120.394 1.00 19.35 ? 93  HIS L NE2 1 
ATOM   2326 N N   . VAL B 2 101 ? 57.008  66.009  114.541 1.00 18.94 ? 94  VAL L N   1 
ATOM   2327 C CA  . VAL B 2 101 ? 57.530  66.929  113.565 1.00 19.13 ? 94  VAL L CA  1 
ATOM   2328 C C   . VAL B 2 101 ? 56.722  68.234  113.715 1.00 18.43 ? 94  VAL L C   1 
ATOM   2329 O O   . VAL B 2 101 ? 55.499  68.162  113.775 1.00 19.24 ? 94  VAL L O   1 
ATOM   2330 C CB  . VAL B 2 101 ? 57.401  66.318  112.151 1.00 19.95 ? 94  VAL L CB  1 
ATOM   2331 C CG1 . VAL B 2 101 ? 57.752  67.330  111.070 1.00 20.34 ? 94  VAL L CG1 1 
ATOM   2332 C CG2 . VAL B 2 101 ? 58.310  65.097  112.040 1.00 20.48 ? 94  VAL L CG2 1 
ATOM   2333 N N   . PRO B 2 102 ? 57.354  69.413  113.792 1.00 17.23 ? 95  PRO L N   1 
ATOM   2334 C CA  . PRO B 2 102 ? 58.800  69.614  113.702 1.00 17.26 ? 95  PRO L CA  1 
ATOM   2335 C C   . PRO B 2 102 ? 59.530  69.380  115.047 1.00 17.76 ? 95  PRO L C   1 
ATOM   2336 O O   . PRO B 2 102 ? 59.024  69.737  116.121 1.00 18.64 ? 95  PRO L O   1 
ATOM   2337 C CB  . PRO B 2 102 ? 58.920  71.064  113.237 1.00 17.19 ? 95  PRO L CB  1 
ATOM   2338 C CG  . PRO B 2 102 ? 57.670  71.738  113.705 1.00 17.30 ? 95  PRO L CG  1 
ATOM   2339 C CD  . PRO B 2 102 ? 56.603  70.683  113.790 1.00 17.05 ? 95  PRO L CD  1 
ATOM   2340 N N   . TYR B 2 103 ? 60.711  68.786  114.985 1.00 17.33 ? 96  TYR L N   1 
ATOM   2341 C CA  . TYR B 2 103 ? 61.512  68.583  116.186 1.00 17.54 ? 96  TYR L CA  1 
ATOM   2342 C C   . TYR B 2 103 ? 61.903  69.941  116.727 1.00 16.51 ? 96  TYR L C   1 
ATOM   2343 O O   . TYR B 2 103 ? 62.104  70.855  115.965 1.00 16.76 ? 96  TYR L O   1 
ATOM   2344 C CB  . TYR B 2 103 ? 62.743  67.727  115.921 1.00 18.37 ? 96  TYR L CB  1 
ATOM   2345 C CG  . TYR B 2 103 ? 62.440  66.502  115.089 1.00 20.81 ? 96  TYR L CG  1 
ATOM   2346 C CD1 . TYR B 2 103 ? 61.251  65.765  115.254 1.00 20.94 ? 96  TYR L CD1 1 
ATOM   2347 C CD2 . TYR B 2 103 ? 63.340  66.083  114.114 1.00 22.75 ? 96  TYR L CD2 1 
ATOM   2348 C CE1 . TYR B 2 103 ? 60.990  64.655  114.469 1.00 22.33 ? 96  TYR L CE1 1 
ATOM   2349 C CE2 . TYR B 2 103 ? 63.097  64.973  113.324 1.00 22.88 ? 96  TYR L CE2 1 
ATOM   2350 C CZ  . TYR B 2 103 ? 61.926  64.263  113.492 1.00 23.32 ? 96  TYR L CZ  1 
ATOM   2351 O OH  . TYR B 2 103 ? 61.718  63.176  112.677 1.00 22.97 ? 96  TYR L OH  1 
ATOM   2352 N N   . THR B 2 104 ? 61.911  70.077  118.052 1.00 15.37 ? 97  THR L N   1 
ATOM   2353 C CA  . THR B 2 104 ? 62.166  71.343  118.711 1.00 14.35 ? 97  THR L CA  1 
ATOM   2354 C C   . THR B 2 104 ? 63.113  71.166  119.877 1.00 13.71 ? 97  THR L C   1 
ATOM   2355 O O   . THR B 2 104 ? 63.342  70.045  120.352 1.00 12.71 ? 97  THR L O   1 
ATOM   2356 C CB  . THR B 2 104 ? 60.875  72.028  119.215 1.00 15.06 ? 97  THR L CB  1 
ATOM   2357 O OG1 . THR B 2 104 ? 60.086  71.112  119.982 1.00 14.71 ? 97  THR L OG1 1 
ATOM   2358 C CG2 . THR B 2 104 ? 60.066  72.576  118.033 1.00 15.50 ? 97  THR L CG2 1 
ATOM   2359 N N   . PHE B 2 105 ? 63.645  72.307  120.300 1.00 12.81 ? 98  PHE L N   1 
ATOM   2360 C CA  . PHE B 2 105 ? 64.651  72.451  121.332 1.00 13.07 ? 98  PHE L CA  1 
ATOM   2361 C C   . PHE B 2 105 ? 64.170  73.421  122.417 1.00 13.28 ? 98  PHE L C   1 
ATOM   2362 O O   . PHE B 2 105 ? 63.530  74.397  122.109 1.00 12.75 ? 98  PHE L O   1 
ATOM   2363 C CB  . PHE B 2 105 ? 65.919  73.050  120.719 1.00 12.69 ? 98  PHE L CB  1 
ATOM   2364 C CG  . PHE B 2 105 ? 66.668  72.107  119.813 1.00 12.70 ? 98  PHE L CG  1 
ATOM   2365 C CD1 . PHE B 2 105 ? 67.644  71.265  120.330 1.00 12.77 ? 98  PHE L CD1 1 
ATOM   2366 C CD2 . PHE B 2 105 ? 66.403  72.058  118.452 1.00 13.23 ? 98  PHE L CD2 1 
ATOM   2367 C CE1 . PHE B 2 105 ? 68.350  70.396  119.520 1.00 12.97 ? 98  PHE L CE1 1 
ATOM   2368 C CE2 . PHE B 2 105 ? 67.106  71.188  117.620 1.00 13.01 ? 98  PHE L CE2 1 
ATOM   2369 C CZ  . PHE B 2 105 ? 68.075  70.356  118.153 1.00 13.25 ? 98  PHE L CZ  1 
ATOM   2370 N N   . GLY B 2 106 ? 64.502  73.138  123.679 1.00 14.04 ? 99  GLY L N   1 
ATOM   2371 C CA  . GLY B 2 106 ? 64.397  74.106  124.768 1.00 13.75 ? 99  GLY L CA  1 
ATOM   2372 C C   . GLY B 2 106 ? 65.350  75.276  124.559 1.00 14.38 ? 99  GLY L C   1 
ATOM   2373 O O   . GLY B 2 106 ? 66.200  75.254  123.670 1.00 14.59 ? 99  GLY L O   1 
ATOM   2374 N N   . GLY B 2 107 ? 65.173  76.318  125.364 1.00 14.72 ? 100 GLY L N   1 
ATOM   2375 C CA  . GLY B 2 107 ? 65.985  77.542  125.278 1.00 14.28 ? 100 GLY L CA  1 
ATOM   2376 C C   . GLY B 2 107 ? 67.324  77.465  125.999 1.00 14.15 ? 100 GLY L C   1 
ATOM   2377 O O   . GLY B 2 107 ? 68.101  78.390  125.942 1.00 14.13 ? 100 GLY L O   1 
ATOM   2378 N N   . GLY B 2 108 ? 67.585  76.371  126.686 1.00 14.64 ? 101 GLY L N   1 
ATOM   2379 C CA  . GLY B 2 108 ? 68.871  76.140  127.334 1.00 15.21 ? 101 GLY L CA  1 
ATOM   2380 C C   . GLY B 2 108 ? 68.897  76.574  128.797 1.00 15.86 ? 101 GLY L C   1 
ATOM   2381 O O   . GLY B 2 108 ? 68.193  77.513  129.191 1.00 15.73 ? 101 GLY L O   1 
ATOM   2382 N N   . THR B 2 109 ? 69.708  75.866  129.596 1.00 16.64 ? 102 THR L N   1 
ATOM   2383 C CA  . THR B 2 109 ? 69.962  76.193  130.988 1.00 16.66 ? 102 THR L CA  1 
ATOM   2384 C C   . THR B 2 109 ? 71.478  76.264  131.152 1.00 17.70 ? 102 THR L C   1 
ATOM   2385 O O   . THR B 2 109 ? 72.175  75.275  130.982 1.00 16.16 ? 102 THR L O   1 
ATOM   2386 C CB  . THR B 2 109 ? 69.399  75.140  131.965 1.00 17.60 ? 102 THR L CB  1 
ATOM   2387 O OG1 . THR B 2 109 ? 67.967  75.126  131.932 1.00 16.81 ? 102 THR L OG1 1 
ATOM   2388 C CG2 . THR B 2 109 ? 69.846  75.419  133.423 1.00 17.68 ? 102 THR L CG2 1 
ATOM   2389 N N   . LYS B 2 110 ? 71.975  77.445  131.487 1.00 19.39 ? 103 LYS L N   1 
ATOM   2390 C CA  . LYS B 2 110 ? 73.377  77.621  131.820 1.00 22.64 ? 103 LYS L CA  1 
ATOM   2391 C C   . LYS B 2 110 ? 73.744  77.052  133.204 1.00 23.53 ? 103 LYS L C   1 
ATOM   2392 O O   . LYS B 2 110 ? 73.182  77.463  134.227 1.00 23.94 ? 103 LYS L O   1 
ATOM   2393 C CB  . LYS B 2 110 ? 73.723  79.102  131.790 1.00 24.75 ? 103 LYS L CB  1 
ATOM   2394 C CG  . LYS B 2 110 ? 75.215  79.371  131.879 1.00 28.20 ? 103 LYS L CG  1 
ATOM   2395 C CD  . LYS B 2 110 ? 75.503  80.829  131.574 1.00 30.34 ? 103 LYS L CD  1 
ATOM   2396 C CE  . LYS B 2 110 ? 76.991  81.113  131.660 1.00 33.02 ? 103 LYS L CE  1 
ATOM   2397 N NZ  . LYS B 2 110 ? 77.216  82.586  131.596 1.00 34.51 ? 103 LYS L NZ  1 
ATOM   2398 N N   . LEU B 2 111 ? 74.679  76.105  133.215 1.00 24.02 ? 104 LEU L N   1 
ATOM   2399 C CA  . LEU B 2 111 ? 75.322  75.639  134.450 1.00 25.14 ? 104 LEU L CA  1 
ATOM   2400 C C   . LEU B 2 111 ? 76.615  76.426  134.663 1.00 24.30 ? 104 LEU L C   1 
ATOM   2401 O O   . LEU B 2 111 ? 77.531  76.344  133.851 1.00 24.27 ? 104 LEU L O   1 
ATOM   2402 C CB  . LEU B 2 111 ? 75.625  74.128  134.366 1.00 25.07 ? 104 LEU L CB  1 
ATOM   2403 C CG  . LEU B 2 111 ? 76.080  73.432  135.649 1.00 25.36 ? 104 LEU L CG  1 
ATOM   2404 C CD1 . LEU B 2 111 ? 75.000  73.460  136.720 1.00 25.72 ? 104 LEU L CD1 1 
ATOM   2405 C CD2 . LEU B 2 111 ? 76.450  71.988  135.362 1.00 26.00 ? 104 LEU L CD2 1 
ATOM   2406 N N   . GLU B 2 112 ? 76.684  77.181  135.751 1.00 25.63 ? 105 GLU L N   1 
ATOM   2407 C CA  . GLU B 2 112 ? 77.861  77.997  136.066 1.00 27.62 ? 105 GLU L CA  1 
ATOM   2408 C C   . GLU B 2 112 ? 78.347  77.818  137.508 1.00 27.25 ? 105 GLU L C   1 
ATOM   2409 O O   . GLU B 2 112 ? 77.657  77.250  138.348 1.00 26.88 ? 105 GLU L O   1 
ATOM   2410 C CB  . GLU B 2 112 ? 77.563  79.477  135.800 1.00 28.76 ? 105 GLU L CB  1 
ATOM   2411 C CG  . GLU B 2 112 ? 76.474  80.065  136.682 1.00 31.35 ? 105 GLU L CG  1 
ATOM   2412 C CD  . GLU B 2 112 ? 76.585  81.580  136.863 1.00 35.01 ? 105 GLU L CD  1 
ATOM   2413 O OE1 . GLU B 2 112 ? 76.999  82.260  135.920 1.00 39.17 ? 105 GLU L OE1 1 
ATOM   2414 O OE2 . GLU B 2 112 ? 76.226  82.112  137.938 1.00 36.54 ? 105 GLU L OE2 1 
ATOM   2415 N N   . ILE B 2 113 ? 79.528  78.356  137.784 1.00 28.62 ? 106 ILE L N   1 
ATOM   2416 C CA  . ILE B 2 113 ? 80.130  78.276  139.119 1.00 29.61 ? 106 ILE L CA  1 
ATOM   2417 C C   . ILE B 2 113 ? 79.621  79.411  139.994 1.00 30.53 ? 106 ILE L C   1 
ATOM   2418 O O   . ILE B 2 113 ? 79.622  80.581  139.594 1.00 27.39 ? 106 ILE L O   1 
ATOM   2419 C CB  . ILE B 2 113 ? 81.665  78.297  139.083 1.00 30.76 ? 106 ILE L CB  1 
ATOM   2420 C CG1 . ILE B 2 113 ? 82.200  77.197  138.157 1.00 31.36 ? 106 ILE L CG1 1 
ATOM   2421 C CG2 . ILE B 2 113 ? 82.254  78.125  140.490 1.00 31.01 ? 106 ILE L CG2 1 
ATOM   2422 C CD1 . ILE B 2 113 ? 81.875  75.778  138.592 1.00 32.63 ? 106 ILE L CD1 1 
ATOM   2423 N N   . LYS B 2 114 ? 79.158  79.022  141.179 1.00 32.89 ? 107 LYS L N   1 
ATOM   2424 C CA  . LYS B 2 114 ? 78.716  79.931  142.218 1.00 35.72 ? 107 LYS L CA  1 
ATOM   2425 C C   . LYS B 2 114 ? 79.918  80.522  142.930 1.00 33.34 ? 107 LYS L C   1 
ATOM   2426 O O   . LYS B 2 114 ? 80.941  79.874  143.091 1.00 31.74 ? 107 LYS L O   1 
ATOM   2427 C CB  . LYS B 2 114 ? 77.861  79.178  143.234 1.00 40.89 ? 107 LYS L CB  1 
ATOM   2428 C CG  . LYS B 2 114 ? 76.936  80.069  144.049 1.00 45.10 ? 107 LYS L CG  1 
ATOM   2429 C CD  . LYS B 2 114 ? 75.811  79.275  144.709 1.00 48.78 ? 107 LYS L CD  1 
ATOM   2430 C CE  . LYS B 2 114 ? 76.254  78.506  145.953 1.00 52.89 ? 107 LYS L CE  1 
ATOM   2431 N NZ  . LYS B 2 114 ? 76.760  77.123  145.699 1.00 55.40 ? 107 LYS L NZ  1 
ATOM   2432 N N   . ARG B 2 115 ? 79.781  81.765  143.352 1.00 32.56 ? 108 ARG L N   1 
ATOM   2433 C CA  . ARG B 2 115 ? 80.777  82.400  144.210 1.00 32.23 ? 108 ARG L CA  1 
ATOM   2434 C C   . ARG B 2 115 ? 80.110  83.490  145.013 1.00 32.58 ? 108 ARG L C   1 
ATOM   2435 O O   . ARG B 2 115 ? 78.922  83.759  144.849 1.00 31.26 ? 108 ARG L O   1 
ATOM   2436 C CB  . ARG B 2 115 ? 81.948  82.959  143.403 1.00 32.30 ? 108 ARG L CB  1 
ATOM   2437 C CG  . ARG B 2 115 ? 81.567  84.052  142.411 1.00 33.15 ? 108 ARG L CG  1 
ATOM   2438 C CD  . ARG B 2 115 ? 82.776  84.890  142.044 1.00 33.57 ? 108 ARG L CD  1 
ATOM   2439 N NE  . ARG B 2 115 ? 83.143  85.787  143.143 1.00 34.38 ? 108 ARG L NE  1 
ATOM   2440 C CZ  . ARG B 2 115 ? 84.386  86.110  143.514 1.00 34.39 ? 108 ARG L CZ  1 
ATOM   2441 N NH1 . ARG B 2 115 ? 85.454  85.612  142.903 1.00 35.28 ? 108 ARG L NH1 1 
ATOM   2442 N NH2 . ARG B 2 115 ? 84.564  86.951  144.524 1.00 36.38 ? 108 ARG L NH2 1 
ATOM   2443 N N   . ALA B 2 116 ? 80.881  84.090  145.905 1.00 34.34 ? 109 ALA L N   1 
ATOM   2444 C CA  . ALA B 2 116 ? 80.407  85.214  146.683 1.00 34.77 ? 109 ALA L CA  1 
ATOM   2445 C C   . ALA B 2 116 ? 80.237  86.395  145.745 1.00 35.15 ? 109 ALA L C   1 
ATOM   2446 O O   . ALA B 2 116 ? 81.066  86.616  144.842 1.00 34.98 ? 109 ALA L O   1 
ATOM   2447 C CB  . ALA B 2 116 ? 81.400  85.550  147.789 1.00 34.87 ? 109 ALA L CB  1 
ATOM   2448 N N   . ASP B 2 117 ? 79.156  87.135  145.960 1.00 34.95 ? 110 ASP L N   1 
ATOM   2449 C CA  . ASP B 2 117 ? 78.939  88.411  145.313 1.00 35.17 ? 110 ASP L CA  1 
ATOM   2450 C C   . ASP B 2 117 ? 80.233  89.219  145.243 1.00 34.79 ? 110 ASP L C   1 
ATOM   2451 O O   . ASP B 2 117 ? 80.992  89.286  146.199 1.00 35.08 ? 110 ASP L O   1 
ATOM   2452 C CB  . ASP B 2 117 ? 77.852  89.209  146.048 1.00 35.83 ? 110 ASP L CB  1 
ATOM   2453 C CG  . ASP B 2 117 ? 76.440  88.665  145.798 1.00 38.46 ? 110 ASP L CG  1 
ATOM   2454 O OD1 . ASP B 2 117 ? 76.294  87.590  145.188 1.00 37.69 ? 110 ASP L OD1 1 
ATOM   2455 O OD2 . ASP B 2 117 ? 75.455  89.325  146.202 1.00 42.01 ? 110 ASP L OD2 1 
ATOM   2456 N N   . ALA B 2 118 ? 80.481  89.804  144.081 1.00 34.95 ? 111 ALA L N   1 
ATOM   2457 C CA  . ALA B 2 118 ? 81.594  90.714  143.878 1.00 33.42 ? 111 ALA L CA  1 
ATOM   2458 C C   . ALA B 2 118 ? 81.043  91.909  143.129 1.00 33.35 ? 111 ALA L C   1 
ATOM   2459 O O   . ALA B 2 118 ? 80.426  91.773  142.064 1.00 33.58 ? 111 ALA L O   1 
ATOM   2460 C CB  . ALA B 2 118 ? 82.707  90.051  143.085 1.00 33.85 ? 111 ALA L CB  1 
ATOM   2461 N N   . ALA B 2 119 ? 81.260  93.084  143.704 1.00 32.67 ? 112 ALA L N   1 
ATOM   2462 C CA  . ALA B 2 119 ? 80.826  94.329  143.102 1.00 31.63 ? 112 ALA L CA  1 
ATOM   2463 C C   . ALA B 2 119 ? 81.788  94.658  141.970 1.00 30.65 ? 112 ALA L C   1 
ATOM   2464 O O   . ALA B 2 119 ? 82.994  94.453  142.135 1.00 29.64 ? 112 ALA L O   1 
ATOM   2465 C CB  . ALA B 2 119 ? 80.844  95.427  144.136 1.00 32.46 ? 112 ALA L CB  1 
ATOM   2466 N N   . PRO B 2 120 ? 81.269  95.152  140.816 1.00 28.04 ? 113 PRO L N   1 
ATOM   2467 C CA  . PRO B 2 120 ? 82.240  95.417  139.766 1.00 28.38 ? 113 PRO L CA  1 
ATOM   2468 C C   . PRO B 2 120 ? 83.115  96.607  140.086 1.00 28.14 ? 113 PRO L C   1 
ATOM   2469 O O   . PRO B 2 120 ? 82.658  97.550  140.700 1.00 28.62 ? 113 PRO L O   1 
ATOM   2470 C CB  . PRO B 2 120 ? 81.376  95.778  138.554 1.00 27.48 ? 113 PRO L CB  1 
ATOM   2471 C CG  . PRO B 2 120 ? 80.149  96.336  139.131 1.00 27.85 ? 113 PRO L CG  1 
ATOM   2472 C CD  . PRO B 2 120 ? 79.919  95.601  140.429 1.00 27.75 ? 113 PRO L CD  1 
ATOM   2473 N N   . SER B 2 121 ? 84.368  96.507  139.708 1.00 27.73 ? 114 SER L N   1 
ATOM   2474 C CA  A SER B 2 121 ? 85.223  97.685  139.599 0.60 28.18 ? 114 SER L CA  1 
ATOM   2475 C CA  B SER B 2 121 ? 85.240  97.690  139.596 0.40 27.85 ? 114 SER L CA  1 
ATOM   2476 C C   . SER B 2 121 ? 84.904  98.471  138.293 1.00 27.84 ? 114 SER L C   1 
ATOM   2477 O O   . SER B 2 121 ? 85.058  97.938  137.195 1.00 27.04 ? 114 SER L O   1 
ATOM   2478 C CB  A SER B 2 121 ? 86.667  97.192  139.620 0.60 27.72 ? 114 SER L CB  1 
ATOM   2479 C CB  B SER B 2 121 ? 86.696  97.208  139.609 0.40 27.28 ? 114 SER L CB  1 
ATOM   2480 O OG  A SER B 2 121 ? 87.514  98.217  140.054 0.60 28.14 ? 114 SER L OG  1 
ATOM   2481 O OG  B SER B 2 121 ? 86.973  96.530  140.822 0.40 26.51 ? 114 SER L OG  1 
ATOM   2482 N N   . VAL B 2 122 ? 84.440  99.727  138.404 1.00 27.80 ? 115 VAL L N   1 
ATOM   2483 C CA  . VAL B 2 122 ? 83.932  100.493 137.246 1.00 26.72 ? 115 VAL L CA  1 
ATOM   2484 C C   . VAL B 2 122 ? 84.912  101.574 136.811 1.00 26.85 ? 115 VAL L C   1 
ATOM   2485 O O   . VAL B 2 122 ? 85.472  102.263 137.637 1.00 26.78 ? 115 VAL L O   1 
ATOM   2486 C CB  . VAL B 2 122 ? 82.571  101.142 137.570 1.00 27.53 ? 115 VAL L CB  1 
ATOM   2487 C CG1 . VAL B 2 122 ? 81.944  101.776 136.324 1.00 27.56 ? 115 VAL L CG1 1 
ATOM   2488 C CG2 . VAL B 2 122 ? 81.620  100.111 138.162 1.00 27.58 ? 115 VAL L CG2 1 
ATOM   2489 N N   . PHE B 2 123 ? 85.106  101.710 135.506 1.00 26.07 ? 116 PHE L N   1 
ATOM   2490 C CA  . PHE B 2 123 ? 86.034  102.672 134.931 1.00 25.96 ? 116 PHE L CA  1 
ATOM   2491 C C   . PHE B 2 123 ? 85.373  103.237 133.675 1.00 26.70 ? 116 PHE L C   1 
ATOM   2492 O O   . PHE B 2 123 ? 84.794  102.483 132.868 1.00 25.70 ? 116 PHE L O   1 
ATOM   2493 C CB  . PHE B 2 123 ? 87.349  101.988 134.519 1.00 27.03 ? 116 PHE L CB  1 
ATOM   2494 C CG  . PHE B 2 123 ? 87.997  101.172 135.612 1.00 27.71 ? 116 PHE L CG  1 
ATOM   2495 C CD1 . PHE B 2 123 ? 87.603  99.873  135.840 1.00 26.67 ? 116 PHE L CD1 1 
ATOM   2496 C CD2 . PHE B 2 123 ? 89.032  101.698 136.390 1.00 28.67 ? 116 PHE L CD2 1 
ATOM   2497 C CE1 . PHE B 2 123 ? 88.193  99.118  136.829 1.00 27.02 ? 116 PHE L CE1 1 
ATOM   2498 C CE2 . PHE B 2 123 ? 89.628  100.938 137.389 1.00 27.82 ? 116 PHE L CE2 1 
ATOM   2499 C CZ  . PHE B 2 123 ? 89.206  99.644  137.603 1.00 26.60 ? 116 PHE L CZ  1 
ATOM   2500 N N   . ILE B 2 124 ? 85.479  104.553 133.498 1.00 25.32 ? 117 ILE L N   1 
ATOM   2501 C CA  . ILE B 2 124 ? 84.966  105.225 132.298 1.00 25.19 ? 117 ILE L CA  1 
ATOM   2502 C C   . ILE B 2 124 ? 86.141  105.760 131.464 1.00 25.05 ? 117 ILE L C   1 
ATOM   2503 O O   . ILE B 2 124 ? 87.106  106.257 132.014 1.00 24.91 ? 117 ILE L O   1 
ATOM   2504 C CB  . ILE B 2 124 ? 83.920  106.323 132.658 1.00 24.80 ? 117 ILE L CB  1 
ATOM   2505 C CG1 . ILE B 2 124 ? 83.324  106.952 131.403 1.00 24.73 ? 117 ILE L CG1 1 
ATOM   2506 C CG2 . ILE B 2 124 ? 84.519  107.420 133.536 1.00 26.09 ? 117 ILE L CG2 1 
ATOM   2507 C CD1 . ILE B 2 124 ? 82.001  107.673 131.640 1.00 24.68 ? 117 ILE L CD1 1 
ATOM   2508 N N   . PHE B 2 125 ? 86.054  105.646 130.143 1.00 26.24 ? 118 PHE L N   1 
ATOM   2509 C CA  . PHE B 2 125 ? 87.105  106.113 129.237 1.00 27.58 ? 118 PHE L CA  1 
ATOM   2510 C C   . PHE B 2 125 ? 86.496  107.071 128.243 1.00 29.35 ? 118 PHE L C   1 
ATOM   2511 O O   . PHE B 2 125 ? 85.540  106.711 127.547 1.00 28.69 ? 118 PHE L O   1 
ATOM   2512 C CB  . PHE B 2 125 ? 87.763  104.972 128.470 1.00 28.19 ? 118 PHE L CB  1 
ATOM   2513 C CG  . PHE B 2 125 ? 88.401  103.947 129.350 1.00 28.93 ? 118 PHE L CG  1 
ATOM   2514 C CD1 . PHE B 2 125 ? 89.644  104.191 129.921 1.00 29.12 ? 118 PHE L CD1 1 
ATOM   2515 C CD2 . PHE B 2 125 ? 87.751  102.743 129.633 1.00 28.50 ? 118 PHE L CD2 1 
ATOM   2516 C CE1 . PHE B 2 125 ? 90.243  103.249 130.740 1.00 29.85 ? 118 PHE L CE1 1 
ATOM   2517 C CE2 . PHE B 2 125 ? 88.347  101.793 130.451 1.00 28.07 ? 118 PHE L CE2 1 
ATOM   2518 C CZ  . PHE B 2 125 ? 89.589  102.048 131.008 1.00 28.91 ? 118 PHE L CZ  1 
ATOM   2519 N N   . PRO B 2 126 ? 87.039  108.300 128.178 1.00 29.42 ? 119 PRO L N   1 
ATOM   2520 C CA  . PRO B 2 126 ? 86.591  109.240 127.168 1.00 28.55 ? 119 PRO L CA  1 
ATOM   2521 C C   . PRO B 2 126 ? 87.073  108.808 125.806 1.00 27.92 ? 119 PRO L C   1 
ATOM   2522 O O   . PRO B 2 126 ? 87.997  108.004 125.720 1.00 28.56 ? 119 PRO L O   1 
ATOM   2523 C CB  . PRO B 2 126 ? 87.279  110.553 127.575 1.00 30.20 ? 119 PRO L CB  1 
ATOM   2524 C CG  . PRO B 2 126 ? 87.539  110.403 129.039 1.00 30.99 ? 119 PRO L CG  1 
ATOM   2525 C CD  . PRO B 2 126 ? 87.903  108.953 129.182 1.00 30.54 ? 119 PRO L CD  1 
ATOM   2526 N N   . PRO B 2 127 ? 86.454  109.322 124.737 1.00 27.20 ? 120 PRO L N   1 
ATOM   2527 C CA  . PRO B 2 127 ? 87.030  109.082 123.419 1.00 28.13 ? 120 PRO L CA  1 
ATOM   2528 C C   . PRO B 2 127 ? 88.447  109.648 123.339 1.00 30.42 ? 120 PRO L C   1 
ATOM   2529 O O   . PRO B 2 127 ? 88.724  110.673 123.943 1.00 29.67 ? 120 PRO L O   1 
ATOM   2530 C CB  . PRO B 2 127 ? 86.095  109.829 122.458 1.00 28.15 ? 120 PRO L CB  1 
ATOM   2531 C CG  . PRO B 2 127 ? 85.266  110.726 123.312 1.00 28.71 ? 120 PRO L CG  1 
ATOM   2532 C CD  . PRO B 2 127 ? 85.258  110.177 124.699 1.00 27.52 ? 120 PRO L CD  1 
ATOM   2533 N N   . SER B 2 128 ? 89.324  108.964 122.609 1.00 33.11 ? 121 SER L N   1 
ATOM   2534 C CA  . SER B 2 128 ? 90.689  109.429 122.385 1.00 34.18 ? 121 SER L CA  1 
ATOM   2535 C C   . SER B 2 128 ? 90.656  110.614 121.444 1.00 35.61 ? 121 SER L C   1 
ATOM   2536 O O   . SER B 2 128 ? 89.749  110.727 120.613 1.00 37.83 ? 121 SER L O   1 
ATOM   2537 C CB  . SER B 2 128 ? 91.520  108.320 121.753 1.00 34.08 ? 121 SER L CB  1 
ATOM   2538 O OG  . SER B 2 128 ? 91.023  107.992 120.468 1.00 35.80 ? 121 SER L OG  1 
ATOM   2539 N N   . ASP B 2 129 ? 91.635  111.496 121.568 1.00 37.18 ? 122 ASP L N   1 
ATOM   2540 C CA  . ASP B 2 129 ? 91.782  112.582 120.602 1.00 39.74 ? 122 ASP L CA  1 
ATOM   2541 C C   . ASP B 2 129 ? 92.018  112.069 119.174 1.00 36.35 ? 122 ASP L C   1 
ATOM   2542 O O   . ASP B 2 129 ? 91.515  112.666 118.230 1.00 35.76 ? 122 ASP L O   1 
ATOM   2543 C CB  . ASP B 2 129 ? 92.857  113.582 121.059 1.00 43.57 ? 122 ASP L CB  1 
ATOM   2544 C CG  . ASP B 2 129 ? 92.387  114.434 122.245 1.00 47.71 ? 122 ASP L CG  1 
ATOM   2545 O OD1 . ASP B 2 129 ? 91.241  114.943 122.202 1.00 48.94 ? 122 ASP L OD1 1 
ATOM   2546 O OD2 . ASP B 2 129 ? 93.149  114.584 123.227 1.00 50.63 ? 122 ASP L OD2 1 
ATOM   2547 N N   . GLU B 2 130 ? 92.714  110.940 119.027 1.00 36.01 ? 123 GLU L N   1 
ATOM   2548 C CA  . GLU B 2 130 ? 92.897  110.279 117.711 1.00 36.34 ? 123 GLU L CA  1 
ATOM   2549 C C   . GLU B 2 130 ? 91.560  109.945 117.039 1.00 32.79 ? 123 GLU L C   1 
ATOM   2550 O O   . GLU B 2 130 ? 91.389  110.143 115.837 1.00 30.30 ? 123 GLU L O   1 
ATOM   2551 C CB  . GLU B 2 130 ? 93.681  108.960 117.823 1.00 41.47 ? 123 GLU L CB  1 
ATOM   2552 C CG  . GLU B 2 130 ? 95.132  109.038 118.281 1.00 45.36 ? 123 GLU L CG  1 
ATOM   2553 C CD  . GLU B 2 130 ? 95.286  109.021 119.793 1.00 48.11 ? 123 GLU L CD  1 
ATOM   2554 O OE1 . GLU B 2 130 ? 96.080  108.203 120.309 1.00 48.44 ? 123 GLU L OE1 1 
ATOM   2555 O OE2 . GLU B 2 130 ? 94.601  109.828 120.473 1.00 51.57 ? 123 GLU L OE2 1 
ATOM   2556 N N   . GLN B 2 131 ? 90.628  109.401 117.818 1.00 30.94 ? 124 GLN L N   1 
ATOM   2557 C CA  . GLN B 2 131 ? 89.318  109.017 117.284 1.00 30.57 ? 124 GLN L CA  1 
ATOM   2558 C C   . GLN B 2 131 ? 88.502  110.253 116.901 1.00 31.57 ? 124 GLN L C   1 
ATOM   2559 O O   . GLN B 2 131 ? 87.875  110.288 115.848 1.00 29.91 ? 124 GLN L O   1 
ATOM   2560 C CB  . GLN B 2 131 ? 88.518  108.144 118.273 1.00 28.79 ? 124 GLN L CB  1 
ATOM   2561 C CG  . GLN B 2 131 ? 87.251  107.585 117.638 1.00 26.82 ? 124 GLN L CG  1 
ATOM   2562 C CD  . GLN B 2 131 ? 86.258  106.946 118.596 1.00 25.56 ? 124 GLN L CD  1 
ATOM   2563 O OE1 . GLN B 2 131 ? 86.357  107.040 119.822 1.00 24.89 ? 124 GLN L OE1 1 
ATOM   2564 N NE2 . GLN B 2 131 ? 85.260  106.316 118.022 1.00 26.11 ? 124 GLN L NE2 1 
ATOM   2565 N N   . LEU B 2 132 ? 88.514  111.259 117.766 1.00 36.07 ? 125 LEU L N   1 
ATOM   2566 C CA  . LEU B 2 132 ? 87.801  112.513 117.502 1.00 39.48 ? 125 LEU L CA  1 
ATOM   2567 C C   . LEU B 2 132 ? 88.290  113.182 116.220 1.00 44.04 ? 125 LEU L C   1 
ATOM   2568 O O   . LEU B 2 132 ? 87.471  113.601 115.397 1.00 48.75 ? 125 LEU L O   1 
ATOM   2569 C CB  . LEU B 2 132 ? 87.950  113.463 118.677 1.00 39.21 ? 125 LEU L CB  1 
ATOM   2570 C CG  . LEU B 2 132 ? 87.182  113.020 119.923 1.00 39.71 ? 125 LEU L CG  1 
ATOM   2571 C CD1 . LEU B 2 132 ? 87.779  113.632 121.178 1.00 40.51 ? 125 LEU L CD1 1 
ATOM   2572 C CD2 . LEU B 2 132 ? 85.708  113.375 119.820 1.00 40.27 ? 125 LEU L CD2 1 
ATOM   2573 N N   . LYS B 2 133 ? 89.611  113.246 116.038 1.00 48.00 ? 126 LYS L N   1 
ATOM   2574 C CA  . LYS B 2 133 ? 90.208  113.658 114.749 1.00 53.44 ? 126 LYS L CA  1 
ATOM   2575 C C   . LYS B 2 133 ? 89.438  113.049 113.585 1.00 53.05 ? 126 LYS L C   1 
ATOM   2576 O O   . LYS B 2 133 ? 88.971  113.764 112.699 1.00 50.95 ? 126 LYS L O   1 
ATOM   2577 C CB  . LYS B 2 133 ? 91.669  113.204 114.620 1.00 56.56 ? 126 LYS L CB  1 
ATOM   2578 C CG  . LYS B 2 133 ? 92.670  113.910 115.528 1.00 58.24 ? 126 LYS L CG  1 
ATOM   2579 C CD  . LYS B 2 133 ? 93.875  114.434 114.750 1.00 58.81 ? 126 LYS L CD  1 
ATOM   2580 C CE  . LYS B 2 133 ? 93.519  115.696 113.965 1.00 60.40 ? 126 LYS L CE  1 
ATOM   2581 N NZ  . LYS B 2 133 ? 94.584  116.109 113.008 1.00 60.86 ? 126 LYS L NZ  1 
ATOM   2582 N N   . SER B 2 134 ? 89.281  111.725 113.648 1.00 54.09 ? 127 SER L N   1 
ATOM   2583 C CA  . SER B 2 134 ? 88.635  110.924 112.596 1.00 53.78 ? 127 SER L CA  1 
ATOM   2584 C C   . SER B 2 134 ? 87.101  111.028 112.516 1.00 51.26 ? 127 SER L C   1 
ATOM   2585 O O   . SER B 2 134 ? 86.498  110.421 111.626 1.00 53.74 ? 127 SER L O   1 
ATOM   2586 C CB  . SER B 2 134 ? 89.099  109.451 112.684 1.00 55.02 ? 127 SER L CB  1 
ATOM   2587 O OG  . SER B 2 134 ? 89.270  109.014 114.023 1.00 53.75 ? 127 SER L OG  1 
ATOM   2588 N N   . GLY B 2 135 ? 86.477  111.775 113.431 1.00 46.97 ? 128 GLY L N   1 
ATOM   2589 C CA  . GLY B 2 135 ? 85.064  112.168 113.307 1.00 46.99 ? 128 GLY L CA  1 
ATOM   2590 C C   . GLY B 2 135 ? 83.997  111.422 114.103 1.00 47.53 ? 128 GLY L C   1 
ATOM   2591 O O   . GLY B 2 135 ? 82.800  111.722 113.962 1.00 49.22 ? 128 GLY L O   1 
ATOM   2592 N N   . THR B 2 136 ? 84.395  110.454 114.929 1.00 45.51 ? 129 THR L N   1 
ATOM   2593 C CA  . THR B 2 136 ? 83.434  109.741 115.796 1.00 43.62 ? 129 THR L CA  1 
ATOM   2594 C C   . THR B 2 136 ? 83.925  109.792 117.233 1.00 38.74 ? 129 THR L C   1 
ATOM   2595 O O   . THR B 2 136 ? 85.112  109.982 117.486 1.00 36.68 ? 129 THR L O   1 
ATOM   2596 C CB  . THR B 2 136 ? 83.222  108.279 115.334 1.00 47.38 ? 129 THR L CB  1 
ATOM   2597 O OG1 . THR B 2 136 ? 82.775  108.280 113.975 1.00 48.12 ? 129 THR L OG1 1 
ATOM   2598 C CG2 . THR B 2 136 ? 82.172  107.529 116.191 1.00 49.30 ? 129 THR L CG2 1 
ATOM   2599 N N   . ALA B 2 137 ? 82.984  109.676 118.164 1.00 34.26 ? 130 ALA L N   1 
ATOM   2600 C CA  . ALA B 2 137 ? 83.283  109.589 119.588 1.00 32.78 ? 130 ALA L CA  1 
ATOM   2601 C C   . ALA B 2 137 ? 82.661  108.310 120.200 1.00 31.46 ? 130 ALA L C   1 
ATOM   2602 O O   . ALA B 2 137 ? 81.437  108.178 120.265 1.00 29.80 ? 130 ALA L O   1 
ATOM   2603 C CB  . ALA B 2 137 ? 82.754  110.821 120.300 1.00 32.25 ? 130 ALA L CB  1 
ATOM   2604 N N   . SER B 2 138 ? 83.528  107.392 120.636 1.00 27.92 ? 131 SER L N   1 
ATOM   2605 C CA  . SER B 2 138 ? 83.148  106.228 121.429 1.00 26.34 ? 131 SER L CA  1 
ATOM   2606 C C   . SER B 2 138 ? 83.516  106.504 122.881 1.00 25.73 ? 131 SER L C   1 
ATOM   2607 O O   . SER B 2 138 ? 84.651  106.872 123.181 1.00 26.71 ? 131 SER L O   1 
ATOM   2608 C CB  . SER B 2 138 ? 83.847  104.961 120.929 1.00 26.62 ? 131 SER L CB  1 
ATOM   2609 O OG  . SER B 2 138 ? 83.400  104.580 119.629 1.00 25.95 ? 131 SER L OG  1 
ATOM   2610 N N   . VAL B 2 139 ? 82.545  106.367 123.776 1.00 24.11 ? 132 VAL L N   1 
ATOM   2611 C CA  . VAL B 2 139 ? 82.775  106.451 125.211 1.00 23.81 ? 132 VAL L CA  1 
ATOM   2612 C C   . VAL B 2 139 ? 82.597  105.044 125.766 1.00 25.27 ? 132 VAL L C   1 
ATOM   2613 O O   . VAL B 2 139 ? 81.639  104.345 125.398 1.00 25.87 ? 132 VAL L O   1 
ATOM   2614 C CB  . VAL B 2 139 ? 81.790  107.409 125.906 1.00 23.83 ? 132 VAL L CB  1 
ATOM   2615 C CG1 . VAL B 2 139 ? 82.297  107.787 127.287 1.00 23.24 ? 132 VAL L CG1 1 
ATOM   2616 C CG2 . VAL B 2 139 ? 81.563  108.661 125.064 1.00 23.56 ? 132 VAL L CG2 1 
ATOM   2617 N N   . VAL B 2 140 ? 83.506  104.625 126.649 1.00 24.53 ? 133 VAL L N   1 
ATOM   2618 C CA  . VAL B 2 140 ? 83.547  103.231 127.082 1.00 23.98 ? 133 VAL L CA  1 
ATOM   2619 C C   . VAL B 2 140 ? 83.420  103.163 128.584 1.00 23.05 ? 133 VAL L C   1 
ATOM   2620 O O   . VAL B 2 140 ? 84.088  103.906 129.292 1.00 22.83 ? 133 VAL L O   1 
ATOM   2621 C CB  . VAL B 2 140 ? 84.832  102.521 126.589 1.00 23.76 ? 133 VAL L CB  1 
ATOM   2622 C CG1 . VAL B 2 140 ? 84.902  101.089 127.113 1.00 23.85 ? 133 VAL L CG1 1 
ATOM   2623 C CG2 . VAL B 2 140 ? 84.862  102.496 125.066 1.00 24.24 ? 133 VAL L CG2 1 
ATOM   2624 N N   . CYS B 2 141 ? 82.554  102.279 129.064 1.00 22.82 ? 134 CYS L N   1 
ATOM   2625 C CA  . CYS B 2 141 ? 82.442  102.000 130.494 1.00 23.95 ? 134 CYS L CA  1 
ATOM   2626 C C   . CYS B 2 141 ? 82.762  100.527 130.762 1.00 23.61 ? 134 CYS L C   1 
ATOM   2627 O O   . CYS B 2 141 ? 82.096  99.647  130.235 1.00 21.41 ? 134 CYS L O   1 
ATOM   2628 C CB  . CYS B 2 141 ? 81.045  102.292 130.980 1.00 25.61 ? 134 CYS L CB  1 
ATOM   2629 S SG  . CYS B 2 141 ? 80.824  102.290 132.774 1.00 29.06 ? 134 CYS L SG  1 
ATOM   2630 N N   . LEU B 2 142 ? 83.771  100.286 131.598 1.00 23.11 ? 135 LEU L N   1 
ATOM   2631 C CA  . LEU B 2 142 ? 84.199  98.943  131.967 1.00 22.57 ? 135 LEU L CA  1 
ATOM   2632 C C   . LEU B 2 142 ? 83.664  98.596  133.349 1.00 23.55 ? 135 LEU L C   1 
ATOM   2633 O O   . LEU B 2 142 ? 83.899  99.340  134.305 1.00 23.83 ? 135 LEU L O   1 
ATOM   2634 C CB  . LEU B 2 142 ? 85.730  98.874  131.982 1.00 22.99 ? 135 LEU L CB  1 
ATOM   2635 C CG  . LEU B 2 142 ? 86.386  97.624  132.579 1.00 22.47 ? 135 LEU L CG  1 
ATOM   2636 C CD1 . LEU B 2 142 ? 85.894  96.361  131.878 1.00 21.71 ? 135 LEU L CD1 1 
ATOM   2637 C CD2 . LEU B 2 142 ? 87.894  97.748  132.472 1.00 23.31 ? 135 LEU L CD2 1 
ATOM   2638 N N   . LEU B 2 143 ? 82.948  97.474  133.447 1.00 23.19 ? 136 LEU L N   1 
ATOM   2639 C CA  . LEU B 2 143 ? 82.602  96.866  134.716 1.00 24.10 ? 136 LEU L CA  1 
ATOM   2640 C C   . LEU B 2 143 ? 83.464  95.611  134.838 1.00 26.59 ? 136 LEU L C   1 
ATOM   2641 O O   . LEU B 2 143 ? 83.285  94.652  134.070 1.00 25.99 ? 136 LEU L O   1 
ATOM   2642 C CB  . LEU B 2 143 ? 81.124  96.469  134.736 1.00 24.95 ? 136 LEU L CB  1 
ATOM   2643 C CG  . LEU B 2 143 ? 80.052  97.564  134.874 1.00 24.06 ? 136 LEU L CG  1 
ATOM   2644 C CD1 . LEU B 2 143 ? 80.143  98.632  133.799 1.00 24.16 ? 136 LEU L CD1 1 
ATOM   2645 C CD2 . LEU B 2 143 ? 78.685  96.904  134.845 1.00 24.20 ? 136 LEU L CD2 1 
ATOM   2646 N N   . ASN B 2 144 ? 84.370  95.606  135.816 1.00 28.04 ? 137 ASN L N   1 
ATOM   2647 C CA  . ASN B 2 144 ? 85.378  94.557  135.930 1.00 29.75 ? 137 ASN L CA  1 
ATOM   2648 C C   . ASN B 2 144 ? 85.215  93.617  137.133 1.00 28.92 ? 137 ASN L C   1 
ATOM   2649 O O   . ASN B 2 144 ? 85.015  94.068  138.265 1.00 29.63 ? 137 ASN L O   1 
ATOM   2650 C CB  . ASN B 2 144 ? 86.782  95.171  135.938 1.00 30.90 ? 137 ASN L CB  1 
ATOM   2651 C CG  . ASN B 2 144 ? 87.813  94.270  135.276 1.00 32.27 ? 137 ASN L CG  1 
ATOM   2652 O OD1 . ASN B 2 144 ? 87.597  93.791  134.174 1.00 35.27 ? 137 ASN L OD1 1 
ATOM   2653 N ND2 . ASN B 2 144 ? 88.940  94.066  135.924 1.00 32.56 ? 137 ASN L ND2 1 
ATOM   2654 N N   . ASN B 2 145 ? 85.328  92.315  136.838 1.00 27.09 ? 138 ASN L N   1 
ATOM   2655 C CA  . ASN B 2 145 ? 85.312  91.208  137.805 1.00 25.73 ? 138 ASN L CA  1 
ATOM   2656 C C   . ASN B 2 145 ? 84.213  91.226  138.831 1.00 24.57 ? 138 ASN L C   1 
ATOM   2657 O O   . ASN B 2 145 ? 84.469  91.444  140.016 1.00 24.52 ? 138 ASN L O   1 
ATOM   2658 C CB  . ASN B 2 145 ? 86.663  91.096  138.505 1.00 26.06 ? 138 ASN L CB  1 
ATOM   2659 C CG  . ASN B 2 145 ? 87.784  90.848  137.542 1.00 26.57 ? 138 ASN L CG  1 
ATOM   2660 O OD1 . ASN B 2 145 ? 87.589  90.782  136.336 1.00 26.87 ? 138 ASN L OD1 1 
ATOM   2661 N ND2 . ASN B 2 145 ? 88.975  90.731  138.067 1.00 30.43 ? 138 ASN L ND2 1 
ATOM   2662 N N   . PHE B 2 146 ? 82.998  90.953  138.367 1.00 24.35 ? 139 PHE L N   1 
ATOM   2663 C CA  . PHE B 2 146 ? 81.819  90.953  139.217 1.00 24.06 ? 139 PHE L CA  1 
ATOM   2664 C C   . PHE B 2 146 ? 81.058  89.635  139.131 1.00 24.81 ? 139 PHE L C   1 
ATOM   2665 O O   . PHE B 2 146 ? 81.235  88.839  138.201 1.00 25.13 ? 139 PHE L O   1 
ATOM   2666 C CB  . PHE B 2 146 ? 80.881  92.128  138.882 1.00 23.49 ? 139 PHE L CB  1 
ATOM   2667 C CG  . PHE B 2 146 ? 80.373  92.123  137.460 1.00 23.12 ? 139 PHE L CG  1 
ATOM   2668 C CD1 . PHE B 2 146 ? 81.102  92.728  136.437 1.00 22.03 ? 139 PHE L CD1 1 
ATOM   2669 C CD2 . PHE B 2 146 ? 79.173  91.501  137.140 1.00 22.40 ? 139 PHE L CD2 1 
ATOM   2670 C CE1 . PHE B 2 146 ? 80.647  92.703  135.119 1.00 21.81 ? 139 PHE L CE1 1 
ATOM   2671 C CE2 . PHE B 2 146 ? 78.714  91.469  135.825 1.00 22.24 ? 139 PHE L CE2 1 
ATOM   2672 C CZ  . PHE B 2 146 ? 79.452  92.073  134.812 1.00 21.92 ? 139 PHE L CZ  1 
ATOM   2673 N N   . TYR B 2 147 ? 80.208  89.440  140.134 1.00 25.26 ? 140 TYR L N   1 
ATOM   2674 C CA  . TYR B 2 147 ? 79.348  88.277  140.246 1.00 26.79 ? 140 TYR L CA  1 
ATOM   2675 C C   . TYR B 2 147 ? 78.204  88.703  141.173 1.00 26.96 ? 140 TYR L C   1 
ATOM   2676 O O   . TYR B 2 147 ? 78.485  89.339  142.178 1.00 26.44 ? 140 TYR L O   1 
ATOM   2677 C CB  . TYR B 2 147 ? 80.113  87.059  140.819 1.00 27.36 ? 140 TYR L CB  1 
ATOM   2678 C CG  . TYR B 2 147 ? 79.271  85.805  140.746 1.00 26.80 ? 140 TYR L CG  1 
ATOM   2679 C CD1 . TYR B 2 147 ? 78.406  85.467  141.778 1.00 26.71 ? 140 TYR L CD1 1 
ATOM   2680 C CD2 . TYR B 2 147 ? 79.269  85.016  139.607 1.00 26.34 ? 140 TYR L CD2 1 
ATOM   2681 C CE1 . TYR B 2 147 ? 77.591  84.352  141.697 1.00 26.87 ? 140 TYR L CE1 1 
ATOM   2682 C CE2 . TYR B 2 147 ? 78.460  83.902  139.512 1.00 25.76 ? 140 TYR L CE2 1 
ATOM   2683 C CZ  . TYR B 2 147 ? 77.618  83.575  140.555 1.00 26.45 ? 140 TYR L CZ  1 
ATOM   2684 O OH  . TYR B 2 147 ? 76.811  82.466  140.464 1.00 25.28 ? 140 TYR L OH  1 
ATOM   2685 N N   . PRO B 2 148 ? 76.936  88.391  140.878 1.00 27.45 ? 141 PRO L N   1 
ATOM   2686 C CA  . PRO B 2 148 ? 76.487  87.593  139.738 1.00 27.55 ? 141 PRO L CA  1 
ATOM   2687 C C   . PRO B 2 148 ? 76.529  88.345  138.404 1.00 28.83 ? 141 PRO L C   1 
ATOM   2688 O O   . PRO B 2 148 ? 76.955  89.491  138.353 1.00 27.28 ? 141 PRO L O   1 
ATOM   2689 C CB  . PRO B 2 148 ? 75.032  87.228  140.115 1.00 27.66 ? 141 PRO L CB  1 
ATOM   2690 C CG  . PRO B 2 148 ? 74.601  88.299  141.042 1.00 28.03 ? 141 PRO L CG  1 
ATOM   2691 C CD  . PRO B 2 148 ? 75.835  88.691  141.812 1.00 27.62 ? 141 PRO L CD  1 
ATOM   2692 N N   . ARG B 2 149 ? 76.113  87.661  137.343 1.00 29.10 ? 142 ARG L N   1 
ATOM   2693 C CA  . ARG B 2 149 ? 76.144  88.186  135.970 1.00 31.79 ? 142 ARG L CA  1 
ATOM   2694 C C   . ARG B 2 149 ? 75.329  89.458  135.799 1.00 29.76 ? 142 ARG L C   1 
ATOM   2695 O O   . ARG B 2 149 ? 75.766  90.373  135.139 1.00 27.77 ? 142 ARG L O   1 
ATOM   2696 C CB  . ARG B 2 149 ? 75.642  87.104  135.001 1.00 33.97 ? 142 ARG L CB  1 
ATOM   2697 C CG  . ARG B 2 149 ? 75.219  87.552  133.610 1.00 37.32 ? 142 ARG L CG  1 
ATOM   2698 C CD  . ARG B 2 149 ? 76.396  87.845  132.706 1.00 40.52 ? 142 ARG L CD  1 
ATOM   2699 N NE  . ARG B 2 149 ? 75.930  87.937  131.316 1.00 45.86 ? 142 ARG L NE  1 
ATOM   2700 C CZ  . ARG B 2 149 ? 76.160  87.048  130.335 1.00 47.66 ? 142 ARG L CZ  1 
ATOM   2701 N NH1 . ARG B 2 149 ? 76.903  85.954  130.524 1.00 44.11 ? 142 ARG L NH1 1 
ATOM   2702 N NH2 . ARG B 2 149 ? 75.648  87.277  129.120 1.00 49.33 ? 142 ARG L NH2 1 
ATOM   2703 N N   . GLU B 2 150 ? 74.151  89.495  136.408 1.00 31.52 ? 143 GLU L N   1 
ATOM   2704 C CA  . GLU B 2 150 ? 73.170  90.565  136.186 1.00 32.65 ? 143 GLU L CA  1 
ATOM   2705 C C   . GLU B 2 150 ? 73.762  91.918  136.585 1.00 31.10 ? 143 GLU L C   1 
ATOM   2706 O O   . GLU B 2 150 ? 74.143  92.111  137.730 1.00 28.51 ? 143 GLU L O   1 
ATOM   2707 C CB  . GLU B 2 150 ? 71.892  90.327  137.001 1.00 34.26 ? 143 GLU L CB  1 
ATOM   2708 C CG  . GLU B 2 150 ? 71.052  89.134  136.541 1.00 39.31 ? 143 GLU L CG  1 
ATOM   2709 C CD  . GLU B 2 150 ? 71.724  87.772  136.779 1.00 41.57 ? 143 GLU L CD  1 
ATOM   2710 O OE1 . GLU B 2 150 ? 72.151  87.469  137.930 1.00 41.31 ? 143 GLU L OE1 1 
ATOM   2711 O OE2 . GLU B 2 150 ? 71.844  87.004  135.800 1.00 42.83 ? 143 GLU L OE2 1 
ATOM   2712 N N   . ALA B 2 151 ? 73.848  92.828  135.625 1.00 29.91 ? 144 ALA L N   1 
ATOM   2713 C CA  . ALA B 2 151 ? 74.265  94.204  135.869 1.00 30.59 ? 144 ALA L CA  1 
ATOM   2714 C C   . ALA B 2 151 ? 73.551  95.144  134.905 1.00 30.77 ? 144 ALA L C   1 
ATOM   2715 O O   . ALA B 2 151 ? 73.425  94.844  133.717 1.00 29.19 ? 144 ALA L O   1 
ATOM   2716 C CB  . ALA B 2 151 ? 75.770  94.340  135.706 1.00 30.33 ? 144 ALA L CB  1 
ATOM   2717 N N   . LYS B 2 152 ? 73.093  96.280  135.427 1.00 31.53 ? 145 LYS L N   1 
ATOM   2718 C CA  . LYS B 2 152 ? 72.479  97.321  134.610 1.00 33.46 ? 145 LYS L CA  1 
ATOM   2719 C C   . LYS B 2 152 ? 73.436  98.516  134.454 1.00 32.26 ? 145 LYS L C   1 
ATOM   2720 O O   . LYS B 2 152 ? 73.897  99.112  135.438 1.00 30.18 ? 145 LYS L O   1 
ATOM   2721 C CB  . LYS B 2 152 ? 71.151  97.751  135.223 1.00 36.34 ? 145 LYS L CB  1 
ATOM   2722 C CG  . LYS B 2 152 ? 70.424  98.836  134.454 1.00 40.25 ? 145 LYS L CG  1 
ATOM   2723 C CD  . LYS B 2 152 ? 69.397  99.522  135.342 1.00 44.11 ? 145 LYS L CD  1 
ATOM   2724 C CE  . LYS B 2 152 ? 68.951  100.841 134.747 1.00 45.82 ? 145 LYS L CE  1 
ATOM   2725 N NZ  . LYS B 2 152 ? 68.028  101.531 135.684 1.00 50.32 ? 145 LYS L NZ  1 
ATOM   2726 N N   . VAL B 2 153 ? 73.720  98.845  133.199 1.00 32.31 ? 146 VAL L N   1 
ATOM   2727 C CA  . VAL B 2 153 ? 74.472  100.034 132.841 1.00 32.32 ? 146 VAL L CA  1 
ATOM   2728 C C   . VAL B 2 153 ? 73.549  101.098 132.239 1.00 31.64 ? 146 VAL L C   1 
ATOM   2729 O O   . VAL B 2 153 ? 72.742  100.826 131.353 1.00 33.02 ? 146 VAL L O   1 
ATOM   2730 C CB  . VAL B 2 153 ? 75.596  99.704  131.858 1.00 33.11 ? 146 VAL L CB  1 
ATOM   2731 C CG1 . VAL B 2 153 ? 76.313  100.966 131.413 1.00 34.62 ? 146 VAL L CG1 1 
ATOM   2732 C CG2 . VAL B 2 153 ? 76.585  98.754  132.514 1.00 33.32 ? 146 VAL L CG2 1 
ATOM   2733 N N   . GLN B 2 154 ? 73.722  102.320 132.708 1.00 31.69 ? 147 GLN L N   1 
ATOM   2734 C CA  . GLN B 2 154 ? 72.947  103.445 132.239 1.00 32.74 ? 147 GLN L CA  1 
ATOM   2735 C C   . GLN B 2 154 ? 73.833  104.636 131.939 1.00 30.12 ? 147 GLN L C   1 
ATOM   2736 O O   . GLN B 2 154 ? 74.546  105.134 132.818 1.00 29.60 ? 147 GLN L O   1 
ATOM   2737 C CB  . GLN B 2 154 ? 71.918  103.831 133.275 1.00 35.93 ? 147 GLN L CB  1 
ATOM   2738 C CG  . GLN B 2 154 ? 70.830  104.691 132.688 1.00 39.10 ? 147 GLN L CG  1 
ATOM   2739 C CD  . GLN B 2 154 ? 69.618  104.746 133.590 1.00 44.55 ? 147 GLN L CD  1 
ATOM   2740 O OE1 . GLN B 2 154 ? 69.597  105.507 134.566 1.00 44.66 ? 147 GLN L OE1 1 
ATOM   2741 N NE2 . GLN B 2 154 ? 68.595  103.937 133.273 1.00 43.93 ? 147 GLN L NE2 1 
ATOM   2742 N N   . TRP B 2 155 ? 73.777  105.065 130.686 1.00 29.13 ? 148 TRP L N   1 
ATOM   2743 C CA  . TRP B 2 155 ? 74.549  106.184 130.172 1.00 28.92 ? 148 TRP L CA  1 
ATOM   2744 C C   . TRP B 2 155 ? 73.712  107.453 130.250 1.00 31.21 ? 148 TRP L C   1 
ATOM   2745 O O   . TRP B 2 155 ? 72.545  107.451 129.861 1.00 30.41 ? 148 TRP L O   1 
ATOM   2746 C CB  . TRP B 2 155 ? 74.913  105.947 128.712 1.00 27.52 ? 148 TRP L CB  1 
ATOM   2747 C CG  . TRP B 2 155 ? 76.029  105.001 128.494 1.00 27.64 ? 148 TRP L CG  1 
ATOM   2748 C CD1 . TRP B 2 155 ? 75.948  103.718 128.022 1.00 27.01 ? 148 TRP L CD1 1 
ATOM   2749 C CD2 . TRP B 2 155 ? 77.413  105.267 128.700 1.00 27.24 ? 148 TRP L CD2 1 
ATOM   2750 N NE1 . TRP B 2 155 ? 77.203  103.174 127.921 1.00 26.75 ? 148 TRP L NE1 1 
ATOM   2751 C CE2 . TRP B 2 155 ? 78.120  104.099 128.342 1.00 26.86 ? 148 TRP L CE2 1 
ATOM   2752 C CE3 . TRP B 2 155 ? 78.128  106.382 129.159 1.00 26.22 ? 148 TRP L CE3 1 
ATOM   2753 C CZ2 . TRP B 2 155 ? 79.505  104.018 128.417 1.00 27.22 ? 148 TRP L CZ2 1 
ATOM   2754 C CZ3 . TRP B 2 155 ? 79.507  106.303 129.230 1.00 27.33 ? 148 TRP L CZ3 1 
ATOM   2755 C CH2 . TRP B 2 155 ? 80.186  105.128 128.861 1.00 27.26 ? 148 TRP L CH2 1 
ATOM   2756 N N   . LYS B 2 156 ? 74.331  108.531 130.735 1.00 34.96 ? 149 LYS L N   1 
ATOM   2757 C CA  . LYS B 2 156 ? 73.697  109.848 130.856 1.00 37.56 ? 149 LYS L CA  1 
ATOM   2758 C C   . LYS B 2 156 ? 74.638  110.906 130.300 1.00 36.77 ? 149 LYS L C   1 
ATOM   2759 O O   . LYS B 2 156 ? 75.837  110.878 130.593 1.00 34.36 ? 149 LYS L O   1 
ATOM   2760 C CB  . LYS B 2 156 ? 73.371  110.144 132.317 1.00 42.37 ? 149 LYS L CB  1 
ATOM   2761 C CG  . LYS B 2 156 ? 72.633  109.001 133.024 1.00 47.54 ? 149 LYS L CG  1 
ATOM   2762 C CD  . LYS B 2 156 ? 72.338  109.274 134.497 1.00 51.52 ? 149 LYS L CD  1 
ATOM   2763 C CE  . LYS B 2 156 ? 71.504  110.535 134.716 1.00 53.75 ? 149 LYS L CE  1 
ATOM   2764 N NZ  . LYS B 2 156 ? 70.288  110.647 133.851 1.00 54.35 ? 149 LYS L NZ  1 
ATOM   2765 N N   . VAL B 2 157 ? 74.100  111.821 129.489 1.00 36.06 ? 150 VAL L N   1 
ATOM   2766 C CA  . VAL B 2 157 ? 74.888  112.898 128.872 1.00 35.32 ? 150 VAL L CA  1 
ATOM   2767 C C   . VAL B 2 157 ? 74.204  114.203 129.245 1.00 35.37 ? 150 VAL L C   1 
ATOM   2768 O O   . VAL B 2 157 ? 73.086  114.463 128.798 1.00 32.41 ? 150 VAL L O   1 
ATOM   2769 C CB  . VAL B 2 157 ? 74.969  112.761 127.336 1.00 35.94 ? 150 VAL L CB  1 
ATOM   2770 C CG1 . VAL B 2 157 ? 75.789  113.887 126.726 1.00 35.82 ? 150 VAL L CG1 1 
ATOM   2771 C CG2 . VAL B 2 157 ? 75.585  111.425 126.953 1.00 37.12 ? 150 VAL L CG2 1 
ATOM   2772 N N   . ASP B 2 158 ? 74.880  115.016 130.060 1.00 35.54 ? 151 ASP L N   1 
ATOM   2773 C CA  . ASP B 2 158 ? 74.279  116.212 130.671 1.00 35.74 ? 151 ASP L CA  1 
ATOM   2774 C C   . ASP B 2 158 ? 72.899  115.898 131.197 1.00 35.21 ? 151 ASP L C   1 
ATOM   2775 O O   . ASP B 2 158 ? 71.938  116.596 130.911 1.00 38.25 ? 151 ASP L O   1 
ATOM   2776 C CB  . ASP B 2 158 ? 74.245  117.379 129.671 1.00 34.01 ? 151 ASP L CB  1 
ATOM   2777 C CG  . ASP B 2 158 ? 75.585  118.042 129.520 1.00 33.72 ? 151 ASP L CG  1 
ATOM   2778 O OD1 . ASP B 2 158 ? 76.402  117.975 130.475 1.00 32.24 ? 151 ASP L OD1 1 
ATOM   2779 O OD2 . ASP B 2 158 ? 75.835  118.621 128.442 1.00 32.70 ? 151 ASP L OD2 1 
ATOM   2780 N N   . ASN B 2 159 ? 72.804  114.796 131.926 1.00 37.10 ? 152 ASN L N   1 
ATOM   2781 C CA  . ASN B 2 159 ? 71.531  114.302 132.458 1.00 40.20 ? 152 ASN L CA  1 
ATOM   2782 C C   . ASN B 2 159 ? 70.487  113.739 131.482 1.00 36.92 ? 152 ASN L C   1 
ATOM   2783 O O   . ASN B 2 159 ? 69.434  113.297 131.923 1.00 36.41 ? 152 ASN L O   1 
ATOM   2784 C CB  . ASN B 2 159 ? 70.879  115.365 133.362 1.00 45.34 ? 152 ASN L CB  1 
ATOM   2785 C CG  . ASN B 2 159 ? 71.204  115.143 134.812 1.00 49.28 ? 152 ASN L CG  1 
ATOM   2786 O OD1 . ASN B 2 159 ? 70.730  114.173 135.413 1.00 51.60 ? 152 ASN L OD1 1 
ATOM   2787 N ND2 . ASN B 2 159 ? 72.033  116.017 135.385 1.00 51.99 ? 152 ASN L ND2 1 
ATOM   2788 N N   . ALA B 2 160 ? 70.765  113.739 130.182 1.00 35.15 ? 153 ALA L N   1 
ATOM   2789 C CA  . ALA B 2 160 ? 69.911  113.066 129.214 1.00 33.52 ? 153 ALA L CA  1 
ATOM   2790 C C   . ALA B 2 160 ? 70.186  111.568 129.253 1.00 33.00 ? 153 ALA L C   1 
ATOM   2791 O O   . ALA B 2 160 ? 71.300  111.135 128.942 1.00 31.90 ? 153 ALA L O   1 
ATOM   2792 C CB  . ALA B 2 160 ? 70.158  113.612 127.815 1.00 33.37 ? 153 ALA L CB  1 
ATOM   2793 N N   . LEU B 2 161 ? 69.177  110.782 129.628 1.00 32.87 ? 154 LEU L N   1 
ATOM   2794 C CA  . LEU B 2 161 ? 69.257  109.327 129.516 1.00 33.23 ? 154 LEU L CA  1 
ATOM   2795 C C   . LEU B 2 161 ? 69.493  108.936 128.063 1.00 32.74 ? 154 LEU L C   1 
ATOM   2796 O O   . LEU B 2 161 ? 68.738  109.352 127.182 1.00 32.78 ? 154 LEU L O   1 
ATOM   2797 C CB  . LEU B 2 161 ? 67.971  108.654 129.975 1.00 35.68 ? 154 LEU L CB  1 
ATOM   2798 C CG  . LEU B 2 161 ? 68.024  107.116 129.860 1.00 36.62 ? 154 LEU L CG  1 
ATOM   2799 C CD1 . LEU B 2 161 ? 68.867  106.565 130.998 1.00 37.81 ? 154 LEU L CD1 1 
ATOM   2800 C CD2 . LEU B 2 161 ? 66.649  106.458 129.837 1.00 37.63 ? 154 LEU L CD2 1 
ATOM   2801 N N   . GLN B 2 162 ? 70.533  108.140 127.826 1.00 29.67 ? 155 GLN L N   1 
ATOM   2802 C CA  . GLN B 2 162 ? 70.852  107.667 126.481 1.00 30.05 ? 155 GLN L CA  1 
ATOM   2803 C C   . GLN B 2 162 ? 70.173  106.322 126.248 1.00 30.51 ? 155 GLN L C   1 
ATOM   2804 O O   . GLN B 2 162 ? 70.304  105.421 127.078 1.00 30.60 ? 155 GLN L O   1 
ATOM   2805 C CB  . GLN B 2 162 ? 72.361  107.523 126.315 1.00 29.67 ? 155 GLN L CB  1 
ATOM   2806 C CG  . GLN B 2 162 ? 73.143  108.802 126.565 1.00 29.06 ? 155 GLN L CG  1 
ATOM   2807 C CD  . GLN B 2 162 ? 72.738  109.894 125.611 1.00 27.48 ? 155 GLN L CD  1 
ATOM   2808 O OE1 . GLN B 2 162 ? 72.941  109.778 124.404 1.00 27.69 ? 155 GLN L OE1 1 
ATOM   2809 N NE2 . GLN B 2 162 ? 72.140  110.948 126.135 1.00 28.58 ? 155 GLN L NE2 1 
ATOM   2810 N N   . SER B 2 163 ? 69.461  106.189 125.126 1.00 29.16 ? 156 SER L N   1 
ATOM   2811 C CA  . SER B 2 163 ? 68.636  104.996 124.862 1.00 28.58 ? 156 SER L CA  1 
ATOM   2812 C C   . SER B 2 163 ? 68.774  104.545 123.404 1.00 27.14 ? 156 SER L C   1 
ATOM   2813 O O   . SER B 2 163 ? 68.383  105.266 122.496 1.00 26.22 ? 156 SER L O   1 
ATOM   2814 C CB  . SER B 2 163 ? 67.167  105.298 125.193 1.00 29.69 ? 156 SER L CB  1 
ATOM   2815 O OG  . SER B 2 163 ? 66.370  104.119 125.178 1.00 29.92 ? 156 SER L OG  1 
ATOM   2816 N N   . GLY B 2 164 ? 69.357  103.359 123.195 1.00 26.74 ? 157 GLY L N   1 
ATOM   2817 C CA  . GLY B 2 164 ? 69.481  102.747 121.856 1.00 25.61 ? 157 GLY L CA  1 
ATOM   2818 C C   . GLY B 2 164 ? 70.763  103.056 121.093 1.00 25.70 ? 157 GLY L C   1 
ATOM   2819 O O   . GLY B 2 164 ? 70.955  102.578 119.963 1.00 24.12 ? 157 GLY L O   1 
ATOM   2820 N N   . ASN B 2 165 ? 71.636  103.859 121.693 1.00 26.10 ? 158 ASN L N   1 
ATOM   2821 C CA  . ASN B 2 165 ? 72.919  104.224 121.066 1.00 27.88 ? 158 ASN L CA  1 
ATOM   2822 C C   . ASN B 2 165 ? 74.126  103.666 121.829 1.00 26.89 ? 158 ASN L C   1 
ATOM   2823 O O   . ASN B 2 165 ? 75.226  104.192 121.740 1.00 26.11 ? 158 ASN L O   1 
ATOM   2824 C CB  . ASN B 2 165 ? 73.031  105.747 120.954 1.00 28.90 ? 158 ASN L CB  1 
ATOM   2825 C CG  . ASN B 2 165 ? 72.916  106.427 122.293 1.00 30.12 ? 158 ASN L CG  1 
ATOM   2826 O OD1 . ASN B 2 165 ? 72.569  105.798 123.283 1.00 32.25 ? 158 ASN L OD1 1 
ATOM   2827 N ND2 . ASN B 2 165 ? 73.189  107.711 122.334 1.00 33.15 ? 158 ASN L ND2 1 
ATOM   2828 N N   . SER B 2 166 ? 73.907  102.616 122.606 1.00 27.60 ? 159 SER L N   1 
ATOM   2829 C CA  . SER B 2 166 ? 74.993  101.931 123.275 1.00 27.28 ? 159 SER L CA  1 
ATOM   2830 C C   . SER B 2 166 ? 74.907  100.454 123.007 1.00 27.30 ? 159 SER L C   1 
ATOM   2831 O O   . SER B 2 166 ? 73.860  99.930  122.641 1.00 27.93 ? 159 SER L O   1 
ATOM   2832 C CB  . SER B 2 166 ? 75.020  102.212 124.782 1.00 27.42 ? 159 SER L CB  1 
ATOM   2833 O OG  . SER B 2 166 ? 73.912  101.633 125.436 1.00 26.58 ? 159 SER L OG  1 
ATOM   2834 N N   . GLN B 2 167 ? 76.049  99.802  123.172 1.00 26.94 ? 160 GLN L N   1 
ATOM   2835 C CA  . GLN B 2 167 ? 76.193  98.365  122.957 1.00 25.85 ? 160 GLN L CA  1 
ATOM   2836 C C   . GLN B 2 167 ? 77.050  97.795  124.087 1.00 25.30 ? 160 GLN L C   1 
ATOM   2837 O O   . GLN B 2 167 ? 78.019  98.424  124.526 1.00 23.18 ? 160 GLN L O   1 
ATOM   2838 C CB  . GLN B 2 167 ? 76.805  98.084  121.585 1.00 25.62 ? 160 GLN L CB  1 
ATOM   2839 C CG  . GLN B 2 167 ? 75.921  98.559  120.428 1.00 26.33 ? 160 GLN L CG  1 
ATOM   2840 C CD  . GLN B 2 167 ? 76.348  98.031  119.062 1.00 26.78 ? 160 GLN L CD  1 
ATOM   2841 O OE1 . GLN B 2 167 ? 77.217  98.595  118.407 1.00 27.32 ? 160 GLN L OE1 1 
ATOM   2842 N NE2 . GLN B 2 167 ? 75.728  96.948  118.627 1.00 28.08 ? 160 GLN L NE2 1 
ATOM   2843 N N   . GLU B 2 168 ? 76.637  96.632  124.585 1.00 25.31 ? 161 GLU L N   1 
ATOM   2844 C CA  . GLU B 2 168 ? 77.354  95.891  125.615 1.00 26.20 ? 161 GLU L CA  1 
ATOM   2845 C C   . GLU B 2 168 ? 77.918  94.580  125.086 1.00 25.71 ? 161 GLU L C   1 
ATOM   2846 O O   . GLU B 2 168 ? 77.364  93.959  124.180 1.00 24.39 ? 161 GLU L O   1 
ATOM   2847 C CB  . GLU B 2 168 ? 76.423  95.488  126.739 1.00 27.41 ? 161 GLU L CB  1 
ATOM   2848 C CG  . GLU B 2 168 ? 75.886  96.610  127.566 1.00 29.26 ? 161 GLU L CG  1 
ATOM   2849 C CD  . GLU B 2 168 ? 75.114  96.093  128.759 1.00 28.74 ? 161 GLU L CD  1 
ATOM   2850 O OE1 . GLU B 2 168 ? 74.663  94.938  128.720 1.00 30.88 ? 161 GLU L OE1 1 
ATOM   2851 O OE2 . GLU B 2 168 ? 74.957  96.836  129.736 1.00 31.61 ? 161 GLU L OE2 1 
ATOM   2852 N N   . SER B 2 169 ? 78.978  94.138  125.746 1.00 25.91 ? 162 SER L N   1 
ATOM   2853 C CA  . SER B 2 169 ? 79.621  92.864  125.457 1.00 25.67 ? 162 SER L CA  1 
ATOM   2854 C C   . SER B 2 169 ? 80.079  92.320  126.815 1.00 25.83 ? 162 SER L C   1 
ATOM   2855 O O   . SER B 2 169 ? 80.524  93.106  127.668 1.00 24.82 ? 162 SER L O   1 
ATOM   2856 C CB  . SER B 2 169 ? 80.794  93.115  124.517 1.00 25.62 ? 162 SER L CB  1 
ATOM   2857 O OG  . SER B 2 169 ? 81.268  91.932  123.933 1.00 26.68 ? 162 SER L OG  1 
ATOM   2858 N N   . VAL B 2 170 ? 79.949  91.002  127.019 1.00 24.79 ? 163 VAL L N   1 
ATOM   2859 C CA  . VAL B 2 170 ? 80.286  90.348  128.300 1.00 24.59 ? 163 VAL L CA  1 
ATOM   2860 C C   . VAL B 2 170 ? 81.231  89.168  128.069 1.00 24.24 ? 163 VAL L C   1 
ATOM   2861 O O   . VAL B 2 170 ? 81.046  88.398  127.133 1.00 22.30 ? 163 VAL L O   1 
ATOM   2862 C CB  . VAL B 2 170 ? 79.039  89.787  129.014 1.00 26.28 ? 163 VAL L CB  1 
ATOM   2863 C CG1 . VAL B 2 170 ? 79.319  89.593  130.497 1.00 26.57 ? 163 VAL L CG1 1 
ATOM   2864 C CG2 . VAL B 2 170 ? 77.847  90.711  128.851 1.00 28.39 ? 163 VAL L CG2 1 
ATOM   2865 N N   . THR B 2 171 ? 82.239  89.026  128.923 1.00 24.59 ? 164 THR L N   1 
ATOM   2866 C CA  . THR B 2 171 ? 83.145  87.875  128.846 1.00 24.63 ? 164 THR L CA  1 
ATOM   2867 C C   . THR B 2 171 ? 82.515  86.622  129.452 1.00 25.36 ? 164 THR L C   1 
ATOM   2868 O O   . THR B 2 171 ? 81.636  86.688  130.318 1.00 23.83 ? 164 THR L O   1 
ATOM   2869 C CB  . THR B 2 171 ? 84.442  88.088  129.635 1.00 24.70 ? 164 THR L CB  1 
ATOM   2870 O OG1 . THR B 2 171 ? 84.118  88.453  130.990 1.00 24.53 ? 164 THR L OG1 1 
ATOM   2871 C CG2 . THR B 2 171 ? 85.295  89.147  128.996 1.00 25.86 ? 164 THR L CG2 1 
ATOM   2872 N N   . GLU B 2 172 ? 83.034  85.484  129.022 1.00 27.94 ? 165 GLU L N   1 
ATOM   2873 C CA  . GLU B 2 172 ? 82.776  84.211  129.681 1.00 31.14 ? 165 GLU L CA  1 
ATOM   2874 C C   . GLU B 2 172 ? 83.279  84.251  131.117 1.00 28.84 ? 165 GLU L C   1 
ATOM   2875 O O   . GLU B 2 172 ? 84.230  84.978  131.444 1.00 26.92 ? 165 GLU L O   1 
ATOM   2876 C CB  . GLU B 2 172 ? 83.427  83.047  128.913 1.00 35.04 ? 165 GLU L CB  1 
ATOM   2877 C CG  . GLU B 2 172 ? 82.648  82.548  127.695 1.00 39.93 ? 165 GLU L CG  1 
ATOM   2878 C CD  . GLU B 2 172 ? 81.137  82.396  127.934 1.00 46.00 ? 165 GLU L CD  1 
ATOM   2879 O OE1 . GLU B 2 172 ? 80.664  81.295  128.335 1.00 49.61 ? 165 GLU L OE1 1 
ATOM   2880 O OE2 . GLU B 2 172 ? 80.413  83.397  127.728 1.00 49.37 ? 165 GLU L OE2 1 
ATOM   2881 N N   . GLN B 2 173 ? 82.609  83.470  131.958 1.00 27.67 ? 166 GLN L N   1 
ATOM   2882 C CA  . GLN B 2 173 ? 82.931  83.373  133.374 1.00 27.72 ? 166 GLN L CA  1 
ATOM   2883 C C   . GLN B 2 173 ? 84.408  83.032  133.573 1.00 28.29 ? 166 GLN L C   1 
ATOM   2884 O O   . GLN B 2 173 ? 84.938  82.158  132.895 1.00 24.82 ? 166 GLN L O   1 
ATOM   2885 C CB  . GLN B 2 173 ? 82.063  82.315  134.059 1.00 28.28 ? 166 GLN L CB  1 
ATOM   2886 C CG  . GLN B 2 173 ? 81.999  82.549  135.562 1.00 28.27 ? 166 GLN L CG  1 
ATOM   2887 C CD  . GLN B 2 173 ? 81.059  81.629  136.308 1.00 27.11 ? 166 GLN L CD  1 
ATOM   2888 O OE1 . GLN B 2 173 ? 80.743  80.532  135.865 1.00 26.60 ? 166 GLN L OE1 1 
ATOM   2889 N NE2 . GLN B 2 173 ? 80.642  82.067  137.482 1.00 27.49 ? 166 GLN L NE2 1 
ATOM   2890 N N   . ASP B 2 174 ? 85.074  83.730  134.490 1.00 29.62 ? 167 ASP L N   1 
ATOM   2891 C CA  . ASP B 2 174 ? 86.514  83.552  134.617 1.00 32.57 ? 167 ASP L CA  1 
ATOM   2892 C C   . ASP B 2 174 ? 86.882  82.165  135.164 1.00 34.30 ? 167 ASP L C   1 
ATOM   2893 O O   . ASP B 2 174 ? 86.380  81.735  136.211 1.00 31.82 ? 167 ASP L O   1 
ATOM   2894 C CB  . ASP B 2 174 ? 87.179  84.618  135.460 1.00 32.15 ? 167 ASP L CB  1 
ATOM   2895 C CG  . ASP B 2 174 ? 88.695  84.480  135.437 1.00 33.73 ? 167 ASP L CG  1 
ATOM   2896 O OD1 . ASP B 2 174 ? 89.285  84.681  134.361 1.00 36.56 ? 167 ASP L OD1 1 
ATOM   2897 O OD2 . ASP B 2 174 ? 89.295  84.128  136.477 1.00 32.28 ? 167 ASP L OD2 1 
ATOM   2898 N N   . SER B 2 175 ? 87.787  81.501  134.444 1.00 36.81 ? 168 SER L N   1 
ATOM   2899 C CA  . SER B 2 175 ? 88.189  80.123  134.735 1.00 39.67 ? 168 SER L CA  1 
ATOM   2900 C C   . SER B 2 175 ? 88.791  79.994  136.134 1.00 38.19 ? 168 SER L C   1 
ATOM   2901 O O   . SER B 2 175 ? 88.557  79.000  136.829 1.00 40.30 ? 168 SER L O   1 
ATOM   2902 C CB  . SER B 2 175 ? 89.182  79.642  133.680 1.00 42.10 ? 168 SER L CB  1 
ATOM   2903 O OG  . SER B 2 175 ? 89.363  78.243  133.766 1.00 46.67 ? 168 SER L OG  1 
ATOM   2904 N N   . LYS B 2 176 ? 89.540  81.017  136.535 1.00 36.04 ? 169 LYS L N   1 
ATOM   2905 C CA  . LYS B 2 176 ? 90.109  81.106  137.882 1.00 36.10 ? 169 LYS L CA  1 
ATOM   2906 C C   . LYS B 2 176 ? 89.163  81.600  138.965 1.00 34.28 ? 169 LYS L C   1 
ATOM   2907 O O   . LYS B 2 176 ? 88.934  80.902  139.932 1.00 35.79 ? 169 LYS L O   1 
ATOM   2908 C CB  . LYS B 2 176 ? 91.330  82.025  137.893 1.00 35.87 ? 169 LYS L CB  1 
ATOM   2909 C CG  . LYS B 2 176 ? 92.652  81.314  137.851 1.00 35.45 ? 169 LYS L CG  1 
ATOM   2910 C CD  . LYS B 2 176 ? 93.699  82.202  138.488 1.00 34.89 ? 169 LYS L CD  1 
ATOM   2911 C CE  . LYS B 2 176 ? 95.062  81.931  137.933 1.00 34.90 ? 169 LYS L CE  1 
ATOM   2912 N NZ  . LYS B 2 176 ? 96.017  82.828  138.634 1.00 34.72 ? 169 LYS L NZ  1 
ATOM   2913 N N   . ASP B 2 177 ? 88.677  82.833  138.819 1.00 34.04 ? 170 ASP L N   1 
ATOM   2914 C CA  . ASP B 2 177 ? 87.951  83.550  139.897 1.00 32.54 ? 170 ASP L CA  1 
ATOM   2915 C C   . ASP B 2 177 ? 86.440  83.598  139.732 1.00 28.08 ? 170 ASP L C   1 
ATOM   2916 O O   . ASP B 2 177 ? 85.749  84.162  140.574 1.00 25.81 ? 170 ASP L O   1 
ATOM   2917 C CB  . ASP B 2 177 ? 88.512  84.982  140.106 1.00 35.36 ? 170 ASP L CB  1 
ATOM   2918 C CG  . ASP B 2 177 ? 88.285  85.910  138.901 1.00 37.16 ? 170 ASP L CG  1 
ATOM   2919 O OD1 . ASP B 2 177 ? 87.181  85.936  138.336 1.00 34.50 ? 170 ASP L OD1 1 
ATOM   2920 O OD2 . ASP B 2 177 ? 89.235  86.627  138.518 1.00 41.90 ? 170 ASP L OD2 1 
ATOM   2921 N N   . SER B 2 178 ? 85.927  83.019  138.651 1.00 25.88 ? 171 SER L N   1 
ATOM   2922 C CA  . SER B 2 178 ? 84.478  82.821  138.491 1.00 25.41 ? 171 SER L CA  1 
ATOM   2923 C C   . SER B 2 178 ? 83.662  84.109  138.317 1.00 24.44 ? 171 SER L C   1 
ATOM   2924 O O   . SER B 2 178 ? 82.445  84.068  138.432 1.00 22.10 ? 171 SER L O   1 
ATOM   2925 C CB  . SER B 2 178 ? 83.902  81.982  139.653 1.00 26.16 ? 171 SER L CB  1 
ATOM   2926 O OG  . SER B 2 178 ? 84.237  80.616  139.510 1.00 28.71 ? 171 SER L OG  1 
ATOM   2927 N N   . THR B 2 179 ? 84.328  85.232  138.027 1.00 23.15 ? 172 THR L N   1 
ATOM   2928 C CA  . THR B 2 179 ? 83.653  86.513  137.814 1.00 23.59 ? 172 THR L CA  1 
ATOM   2929 C C   . THR B 2 179 ? 83.405  86.738  136.340 1.00 23.32 ? 172 THR L C   1 
ATOM   2930 O O   . THR B 2 179 ? 84.003  86.078  135.483 1.00 22.11 ? 172 THR L O   1 
ATOM   2931 C CB  . THR B 2 179 ? 84.501  87.723  138.283 1.00 23.10 ? 172 THR L CB  1 
ATOM   2932 O OG1 . THR B 2 179 ? 85.677  87.835  137.472 1.00 22.91 ? 172 THR L OG1 1 
ATOM   2933 C CG2 . THR B 2 179 ? 84.882  87.596  139.744 1.00 23.99 ? 172 THR L CG2 1 
ATOM   2934 N N   . TYR B 2 180 ? 82.551  87.724  136.079 1.00 23.53 ? 173 TYR L N   1 
ATOM   2935 C CA  . TYR B 2 180 ? 82.296  88.241  134.744 1.00 23.18 ? 173 TYR L CA  1 
ATOM   2936 C C   . TYR B 2 180 ? 82.866  89.648  134.646 1.00 22.56 ? 173 TYR L C   1 
ATOM   2937 O O   . TYR B 2 180 ? 83.011  90.344  135.653 1.00 21.33 ? 173 TYR L O   1 
ATOM   2938 C CB  . TYR B 2 180 ? 80.792  88.309  134.493 1.00 24.54 ? 173 TYR L CB  1 
ATOM   2939 C CG  . TYR B 2 180 ? 80.107  86.959  134.476 1.00 25.08 ? 173 TYR L CG  1 
ATOM   2940 C CD1 . TYR B 2 180 ? 80.117  86.177  133.339 1.00 26.51 ? 173 TYR L CD1 1 
ATOM   2941 C CD2 . TYR B 2 180 ? 79.450  86.477  135.591 1.00 27.10 ? 173 TYR L CD2 1 
ATOM   2942 C CE1 . TYR B 2 180 ? 79.494  84.943  133.302 1.00 27.43 ? 173 TYR L CE1 1 
ATOM   2943 C CE2 . TYR B 2 180 ? 78.816  85.241  135.574 1.00 28.54 ? 173 TYR L CE2 1 
ATOM   2944 C CZ  . TYR B 2 180 ? 78.851  84.476  134.427 1.00 28.98 ? 173 TYR L CZ  1 
ATOM   2945 O OH  . TYR B 2 180 ? 78.219  83.254  134.384 1.00 32.24 ? 173 TYR L OH  1 
ATOM   2946 N N   . SER B 2 181 ? 83.180  90.048  133.421 1.00 22.85 ? 174 SER L N   1 
ATOM   2947 C CA  . SER B 2 181 ? 83.458  91.446  133.075 1.00 23.26 ? 174 SER L CA  1 
ATOM   2948 C C   . SER B 2 181 ? 82.556  91.896  131.903 1.00 23.99 ? 174 SER L C   1 
ATOM   2949 O O   . SER B 2 181 ? 82.109  91.074  131.101 1.00 24.02 ? 174 SER L O   1 
ATOM   2950 C CB  . SER B 2 181 ? 84.933  91.634  132.751 1.00 22.47 ? 174 SER L CB  1 
ATOM   2951 O OG  . SER B 2 181 ? 85.712  91.544  133.930 1.00 21.97 ? 174 SER L OG  1 
ATOM   2952 N N   . LEU B 2 182 ? 82.288  93.199  131.840 1.00 24.23 ? 175 LEU L N   1 
ATOM   2953 C CA  . LEU B 2 182 ? 81.384  93.796  130.860 1.00 24.92 ? 175 LEU L CA  1 
ATOM   2954 C C   . LEU B 2 182 ? 81.932  95.152  130.370 1.00 25.61 ? 175 LEU L C   1 
ATOM   2955 O O   . LEU B 2 182 ? 82.376  95.971  131.164 1.00 25.98 ? 175 LEU L O   1 
ATOM   2956 C CB  . LEU B 2 182 ? 79.994  93.987  131.487 1.00 25.65 ? 175 LEU L CB  1 
ATOM   2957 C CG  . LEU B 2 182 ? 78.861  94.641  130.663 1.00 26.61 ? 175 LEU L CG  1 
ATOM   2958 C CD1 . LEU B 2 182 ? 77.495  94.055  131.007 1.00 26.43 ? 175 LEU L CD1 1 
ATOM   2959 C CD2 . LEU B 2 182 ? 78.817  96.158  130.813 1.00 26.00 ? 175 LEU L CD2 1 
ATOM   2960 N N   . SER B 2 183 ? 81.880  95.386  129.063 1.00 25.38 ? 176 SER L N   1 
ATOM   2961 C CA  . SER B 2 183 ? 82.126  96.712  128.517 1.00 26.03 ? 176 SER L CA  1 
ATOM   2962 C C   . SER B 2 183 ? 80.880  97.232  127.821 1.00 24.71 ? 176 SER L C   1 
ATOM   2963 O O   . SER B 2 183 ? 80.253  96.506  127.053 1.00 24.87 ? 176 SER L O   1 
ATOM   2964 C CB  . SER B 2 183 ? 83.265  96.685  127.512 1.00 26.43 ? 176 SER L CB  1 
ATOM   2965 O OG  . SER B 2 183 ? 82.819  96.069  126.327 1.00 29.55 ? 176 SER L OG  1 
ATOM   2966 N N   . SER B 2 184 ? 80.556  98.501  128.064 1.00 24.35 ? 177 SER L N   1 
ATOM   2967 C CA  . SER B 2 184 ? 79.486  99.193  127.330 1.00 23.40 ? 177 SER L CA  1 
ATOM   2968 C C   . SER B 2 184 ? 80.064  100.382 126.584 1.00 22.13 ? 177 SER L C   1 
ATOM   2969 O O   . SER B 2 184 ? 80.718  101.217 127.184 1.00 22.34 ? 177 SER L O   1 
ATOM   2970 C CB  . SER B 2 184 ? 78.397  99.645  128.284 1.00 24.10 ? 177 SER L CB  1 
ATOM   2971 O OG  . SER B 2 184 ? 77.400  100.373 127.585 1.00 24.80 ? 177 SER L OG  1 
ATOM   2972 N N   . THR B 2 185 ? 79.815  100.451 125.281 1.00 21.60 ? 178 THR L N   1 
ATOM   2973 C CA  . THR B 2 185 ? 80.267  101.549 124.443 1.00 22.32 ? 178 THR L CA  1 
ATOM   2974 C C   . THR B 2 185 ? 79.115  102.454 124.046 1.00 23.51 ? 178 THR L C   1 
ATOM   2975 O O   . THR B 2 185 ? 78.131  102.002 123.450 1.00 24.55 ? 178 THR L O   1 
ATOM   2976 C CB  . THR B 2 185 ? 80.900  101.005 123.160 1.00 22.83 ? 178 THR L CB  1 
ATOM   2977 O OG1 . THR B 2 185 ? 81.966  100.132 123.519 1.00 23.31 ? 178 THR L OG1 1 
ATOM   2978 C CG2 . THR B 2 185 ? 81.427  102.124 122.244 1.00 22.13 ? 178 THR L CG2 1 
ATOM   2979 N N   . LEU B 2 186 ? 79.256  103.733 124.343 1.00 24.20 ? 179 LEU L N   1 
ATOM   2980 C CA  . LEU B 2 186 ? 78.310  104.741 123.888 1.00 24.58 ? 179 LEU L CA  1 
ATOM   2981 C C   . LEU B 2 186 ? 78.920  105.446 122.681 1.00 26.97 ? 179 LEU L C   1 
ATOM   2982 O O   . LEU B 2 186 ? 80.049  105.942 122.758 1.00 28.01 ? 179 LEU L O   1 
ATOM   2983 C CB  . LEU B 2 186 ? 78.063  105.735 124.998 1.00 24.30 ? 179 LEU L CB  1 
ATOM   2984 C CG  . LEU B 2 186 ? 77.097  106.857 124.624 1.00 24.13 ? 179 LEU L CG  1 
ATOM   2985 C CD1 . LEU B 2 186 ? 75.657  106.355 124.630 1.00 24.37 ? 179 LEU L CD1 1 
ATOM   2986 C CD2 . LEU B 2 186 ? 77.309  108.037 125.552 1.00 23.48 ? 179 LEU L CD2 1 
ATOM   2987 N N   . THR B 2 187 ? 78.187  105.469 121.573 1.00 27.64 ? 180 THR L N   1 
ATOM   2988 C CA  . THR B 2 187 ? 78.635  106.093 120.335 1.00 29.88 ? 180 THR L CA  1 
ATOM   2989 C C   . THR B 2 187 ? 77.875  107.395 120.095 1.00 31.78 ? 180 THR L C   1 
ATOM   2990 O O   . THR B 2 187 ? 76.639  107.400 120.137 1.00 30.46 ? 180 THR L O   1 
ATOM   2991 C CB  . THR B 2 187 ? 78.351  105.174 119.150 1.00 32.08 ? 180 THR L CB  1 
ATOM   2992 O OG1 . THR B 2 187 ? 78.829  103.857 119.450 1.00 34.83 ? 180 THR L OG1 1 
ATOM   2993 C CG2 . THR B 2 187 ? 79.047  105.675 117.890 1.00 33.86 ? 180 THR L CG2 1 
ATOM   2994 N N   . LEU B 2 188 ? 78.619  108.484 119.872 1.00 32.52 ? 181 LEU L N   1 
ATOM   2995 C CA  . LEU B 2 188 ? 78.069  109.763 119.368 1.00 35.00 ? 181 LEU L CA  1 
ATOM   2996 C C   . LEU B 2 188 ? 78.926  110.307 118.232 1.00 34.27 ? 181 LEU L C   1 
ATOM   2997 O O   . LEU B 2 188 ? 80.076  109.881 118.036 1.00 32.78 ? 181 LEU L O   1 
ATOM   2998 C CB  . LEU B 2 188 ? 78.033  110.862 120.436 1.00 36.64 ? 181 LEU L CB  1 
ATOM   2999 C CG  . LEU B 2 188 ? 77.512  110.597 121.844 1.00 40.26 ? 181 LEU L CG  1 
ATOM   3000 C CD1 . LEU B 2 188 ? 78.563  109.906 122.694 1.00 41.76 ? 181 LEU L CD1 1 
ATOM   3001 C CD2 . LEU B 2 188 ? 77.133  111.907 122.511 1.00 41.32 ? 181 LEU L CD2 1 
ATOM   3002 N N   . SER B 2 189 ? 78.370  111.293 117.527 1.00 31.48 ? 182 SER L N   1 
ATOM   3003 C CA  . SER B 2 189 ? 79.117  112.035 116.538 1.00 30.74 ? 182 SER L CA  1 
ATOM   3004 C C   . SER B 2 189 ? 80.096  112.911 117.285 1.00 30.93 ? 182 SER L C   1 
ATOM   3005 O O   . SER B 2 189 ? 79.886  113.255 118.454 1.00 31.31 ? 182 SER L O   1 
ATOM   3006 C CB  . SER B 2 189 ? 78.208  112.910 115.660 1.00 29.68 ? 182 SER L CB  1 
ATOM   3007 O OG  . SER B 2 189 ? 77.613  113.950 116.419 1.00 29.30 ? 182 SER L OG  1 
ATOM   3008 N N   . LYS B 2 190 ? 81.168  113.257 116.596 1.00 32.32 ? 183 LYS L N   1 
ATOM   3009 C CA  . LYS B 2 190 ? 82.116  114.252 117.078 1.00 37.10 ? 183 LYS L CA  1 
ATOM   3010 C C   . LYS B 2 190 ? 81.400  115.556 117.516 1.00 37.91 ? 183 LYS L C   1 
ATOM   3011 O O   . LYS B 2 190 ? 81.598  116.055 118.629 1.00 38.63 ? 183 LYS L O   1 
ATOM   3012 C CB  . LYS B 2 190 ? 83.126  114.559 115.969 1.00 40.42 ? 183 LYS L CB  1 
ATOM   3013 C CG  . LYS B 2 190 ? 84.478  115.038 116.454 1.00 42.74 ? 183 LYS L CG  1 
ATOM   3014 C CD  . LYS B 2 190 ? 85.072  116.063 115.495 1.00 45.82 ? 183 LYS L CD  1 
ATOM   3015 C CE  . LYS B 2 190 ? 86.239  116.817 116.116 1.00 48.05 ? 183 LYS L CE  1 
ATOM   3016 N NZ  . LYS B 2 190 ? 86.270  118.230 115.644 1.00 50.75 ? 183 LYS L NZ  1 
ATOM   3017 N N   . ALA B 2 191 ? 80.551  116.070 116.631 1.00 38.20 ? 184 ALA L N   1 
ATOM   3018 C CA  . ALA B 2 191 ? 79.773  117.290 116.867 1.00 38.95 ? 184 ALA L CA  1 
ATOM   3019 C C   . ALA B 2 191 ? 78.983  117.242 118.174 1.00 39.07 ? 184 ALA L C   1 
ATOM   3020 O O   . ALA B 2 191 ? 79.093  118.151 119.010 1.00 39.10 ? 184 ALA L O   1 
ATOM   3021 C CB  . ALA B 2 191 ? 78.813  117.524 115.700 1.00 39.47 ? 184 ALA L CB  1 
ATOM   3022 N N   . ASP B 2 192 ? 78.198  116.173 118.336 1.00 37.38 ? 185 ASP L N   1 
ATOM   3023 C CA  . ASP B 2 192 ? 77.360  115.972 119.535 1.00 34.43 ? 185 ASP L CA  1 
ATOM   3024 C C   . ASP B 2 192 ? 78.159  115.778 120.807 1.00 33.19 ? 185 ASP L C   1 
ATOM   3025 O O   . ASP B 2 192 ? 77.757  116.251 121.874 1.00 32.81 ? 185 ASP L O   1 
ATOM   3026 C CB  . ASP B 2 192 ? 76.432  114.772 119.343 1.00 34.38 ? 185 ASP L CB  1 
ATOM   3027 C CG  . ASP B 2 192 ? 75.264  115.080 118.441 1.00 36.05 ? 185 ASP L CG  1 
ATOM   3028 O OD1 . ASP B 2 192 ? 74.836  116.255 118.381 1.00 38.92 ? 185 ASP L OD1 1 
ATOM   3029 O OD2 . ASP B 2 192 ? 74.745  114.147 117.806 1.00 36.60 ? 185 ASP L OD2 1 
ATOM   3030 N N   . TYR B 2 193 ? 79.279  115.069 120.697 1.00 32.47 ? 186 TYR L N   1 
ATOM   3031 C CA  . TYR B 2 193 ? 80.160  114.870 121.831 1.00 33.03 ? 186 TYR L CA  1 
ATOM   3032 C C   . TYR B 2 193 ? 80.707  116.224 122.321 1.00 35.69 ? 186 TYR L C   1 
ATOM   3033 O O   . TYR B 2 193 ? 80.730  116.518 123.532 1.00 34.52 ? 186 TYR L O   1 
ATOM   3034 C CB  . TYR B 2 193 ? 81.297  113.897 121.486 1.00 33.11 ? 186 TYR L CB  1 
ATOM   3035 C CG  . TYR B 2 193 ? 82.302  113.794 122.600 1.00 32.34 ? 186 TYR L CG  1 
ATOM   3036 C CD1 . TYR B 2 193 ? 81.996  113.103 123.766 1.00 33.71 ? 186 TYR L CD1 1 
ATOM   3037 C CD2 . TYR B 2 193 ? 83.533  114.425 122.515 1.00 32.44 ? 186 TYR L CD2 1 
ATOM   3038 C CE1 . TYR B 2 193 ? 82.893  113.032 124.816 1.00 32.88 ? 186 TYR L CE1 1 
ATOM   3039 C CE2 . TYR B 2 193 ? 84.442  114.347 123.553 1.00 32.64 ? 186 TYR L CE2 1 
ATOM   3040 C CZ  . TYR B 2 193 ? 84.117  113.648 124.695 1.00 31.47 ? 186 TYR L CZ  1 
ATOM   3041 O OH  . TYR B 2 193 ? 85.003  113.598 125.730 1.00 31.25 ? 186 TYR L OH  1 
ATOM   3042 N N   . GLU B 2 194 ? 81.099  117.061 121.364 1.00 37.39 ? 187 GLU L N   1 
ATOM   3043 C CA  . GLU B 2 194 ? 81.558  118.419 121.672 1.00 41.05 ? 187 GLU L CA  1 
ATOM   3044 C C   . GLU B 2 194 ? 80.467  119.417 122.124 1.00 40.22 ? 187 GLU L C   1 
ATOM   3045 O O   . GLU B 2 194 ? 80.805  120.503 122.592 1.00 40.75 ? 187 GLU L O   1 
ATOM   3046 C CB  . GLU B 2 194 ? 82.394  118.970 120.515 1.00 42.30 ? 187 GLU L CB  1 
ATOM   3047 C CG  . GLU B 2 194 ? 83.789  118.352 120.524 1.00 45.40 ? 187 GLU L CG  1 
ATOM   3048 C CD  . GLU B 2 194 ? 84.558  118.503 119.226 1.00 47.25 ? 187 GLU L CD  1 
ATOM   3049 O OE1 . GLU B 2 194 ? 83.961  118.861 118.187 1.00 51.10 ? 187 GLU L OE1 1 
ATOM   3050 O OE2 . GLU B 2 194 ? 85.776  118.233 119.250 1.00 45.96 ? 187 GLU L OE2 1 
ATOM   3051 N N   . LYS B 2 195 ? 79.191  119.052 122.012 1.00 37.82 ? 188 LYS L N   1 
ATOM   3052 C CA  . LYS B 2 195 ? 78.087  119.889 122.525 1.00 39.02 ? 188 LYS L CA  1 
ATOM   3053 C C   . LYS B 2 195 ? 77.829  119.739 124.018 1.00 37.51 ? 188 LYS L C   1 
ATOM   3054 O O   . LYS B 2 195 ? 77.170  120.589 124.601 1.00 32.80 ? 188 LYS L O   1 
ATOM   3055 C CB  . LYS B 2 195 ? 76.775  119.598 121.790 1.00 40.12 ? 188 LYS L CB  1 
ATOM   3056 C CG  . LYS B 2 195 ? 76.734  120.062 120.349 1.00 42.03 ? 188 LYS L CG  1 
ATOM   3057 C CD  . LYS B 2 195 ? 75.441  119.609 119.683 1.00 45.16 ? 188 LYS L CD  1 
ATOM   3058 C CE  . LYS B 2 195 ? 75.307  120.138 118.265 1.00 47.35 ? 188 LYS L CE  1 
ATOM   3059 N NZ  . LYS B 2 195 ? 76.240  119.497 117.294 1.00 50.68 ? 188 LYS L NZ  1 
ATOM   3060 N N   . HIS B 2 196 ? 78.332  118.666 124.636 1.00 38.23 ? 189 HIS L N   1 
ATOM   3061 C CA  . HIS B 2 196 ? 78.007  118.369 126.046 1.00 36.40 ? 189 HIS L CA  1 
ATOM   3062 C C   . HIS B 2 196 ? 79.213  118.248 126.909 1.00 33.62 ? 189 HIS L C   1 
ATOM   3063 O O   . HIS B 2 196 ? 80.309  118.155 126.408 1.00 35.46 ? 189 HIS L O   1 
ATOM   3064 C CB  . HIS B 2 196 ? 77.191  117.096 126.144 1.00 36.57 ? 189 HIS L CB  1 
ATOM   3065 C CG  . HIS B 2 196 ? 75.949  117.140 125.325 1.00 38.09 ? 189 HIS L CG  1 
ATOM   3066 N ND1 . HIS B 2 196 ? 75.880  116.579 124.070 1.00 39.67 ? 189 HIS L ND1 1 
ATOM   3067 C CD2 . HIS B 2 196 ? 74.750  117.729 125.544 1.00 38.77 ? 189 HIS L CD2 1 
ATOM   3068 C CE1 . HIS B 2 196 ? 74.677  116.784 123.566 1.00 38.51 ? 189 HIS L CE1 1 
ATOM   3069 N NE2 . HIS B 2 196 ? 73.973  117.479 124.441 1.00 38.18 ? 189 HIS L NE2 1 
ATOM   3070 N N   . LYS B 2 197 ? 78.989  118.244 128.217 1.00 34.20 ? 190 LYS L N   1 
ATOM   3071 C CA  . LYS B 2 197 ? 80.066  118.237 129.203 1.00 37.08 ? 190 LYS L CA  1 
ATOM   3072 C C   . LYS B 2 197 ? 80.133  116.966 130.050 1.00 34.25 ? 190 LYS L C   1 
ATOM   3073 O O   . LYS B 2 197 ? 81.162  116.304 130.070 1.00 33.41 ? 190 LYS L O   1 
ATOM   3074 C CB  . LYS B 2 197 ? 79.940  119.452 130.117 1.00 41.03 ? 190 LYS L CB  1 
ATOM   3075 C CG  . LYS B 2 197 ? 81.142  119.667 131.030 1.00 46.64 ? 190 LYS L CG  1 
ATOM   3076 C CD  . LYS B 2 197 ? 80.800  120.545 132.227 1.00 53.52 ? 190 LYS L CD  1 
ATOM   3077 C CE  . LYS B 2 197 ? 80.248  121.906 131.834 1.00 56.77 ? 190 LYS L CE  1 
ATOM   3078 N NZ  . LYS B 2 197 ? 80.049  122.759 133.037 1.00 60.47 ? 190 LYS L NZ  1 
ATOM   3079 N N   . VAL B 2 198 ? 79.057  116.649 130.764 1.00 32.28 ? 191 VAL L N   1 
ATOM   3080 C CA  . VAL B 2 198 ? 79.072  115.534 131.729 1.00 31.18 ? 191 VAL L CA  1 
ATOM   3081 C C   . VAL B 2 198 ? 78.703  114.201 131.063 1.00 30.27 ? 191 VAL L C   1 
ATOM   3082 O O   . VAL B 2 198 ? 77.545  113.973 130.707 1.00 29.13 ? 191 VAL L O   1 
ATOM   3083 C CB  . VAL B 2 198 ? 78.128  115.780 132.919 1.00 32.33 ? 191 VAL L CB  1 
ATOM   3084 C CG1 . VAL B 2 198 ? 78.355  114.742 134.011 1.00 32.78 ? 191 VAL L CG1 1 
ATOM   3085 C CG2 . VAL B 2 198 ? 78.331  117.174 133.500 1.00 33.25 ? 191 VAL L CG2 1 
ATOM   3086 N N   . TYR B 2 199 ? 79.699  113.336 130.885 1.00 30.50 ? 192 TYR L N   1 
ATOM   3087 C CA  . TYR B 2 199 ? 79.468  111.955 130.452 1.00 30.53 ? 192 TYR L CA  1 
ATOM   3088 C C   . TYR B 2 199 ? 79.564  111.051 131.660 1.00 30.58 ? 192 TYR L C   1 
ATOM   3089 O O   . TYR B 2 199 ? 80.553  111.089 132.376 1.00 31.44 ? 192 TYR L O   1 
ATOM   3090 C CB  . TYR B 2 199 ? 80.456  111.568 129.375 1.00 31.40 ? 192 TYR L CB  1 
ATOM   3091 C CG  . TYR B 2 199 ? 80.189  112.356 128.122 1.00 31.46 ? 192 TYR L CG  1 
ATOM   3092 C CD1 . TYR B 2 199 ? 80.645  113.663 127.997 1.00 32.29 ? 192 TYR L CD1 1 
ATOM   3093 C CD2 . TYR B 2 199 ? 79.434  111.825 127.089 1.00 31.30 ? 192 TYR L CD2 1 
ATOM   3094 C CE1 . TYR B 2 199 ? 80.376  114.417 126.864 1.00 32.22 ? 192 TYR L CE1 1 
ATOM   3095 C CE2 . TYR B 2 199 ? 79.167  112.562 125.946 1.00 32.36 ? 192 TYR L CE2 1 
ATOM   3096 C CZ  . TYR B 2 199 ? 79.642  113.864 125.844 1.00 33.10 ? 192 TYR L CZ  1 
ATOM   3097 O OH  . TYR B 2 199 ? 79.384  114.617 124.727 1.00 32.25 ? 192 TYR L OH  1 
ATOM   3098 N N   . ALA B 2 200 ? 78.518  110.253 131.874 1.00 29.49 ? 193 ALA L N   1 
ATOM   3099 C CA  . ALA B 2 200 ? 78.296  109.530 133.118 1.00 27.98 ? 193 ALA L CA  1 
ATOM   3100 C C   . ALA B 2 200 ? 77.720  108.135 132.882 1.00 27.87 ? 193 ALA L C   1 
ATOM   3101 O O   . ALA B 2 200 ? 76.680  107.979 132.230 1.00 26.56 ? 193 ALA L O   1 
ATOM   3102 C CB  . ALA B 2 200 ? 77.361  110.314 134.014 1.00 28.68 ? 193 ALA L CB  1 
ATOM   3103 N N   . CYS B 2 201 ? 78.411  107.141 133.438 1.00 27.66 ? 194 CYS L N   1 
ATOM   3104 C CA  . CYS B 2 201 ? 78.045  105.732 133.386 1.00 28.09 ? 194 CYS L CA  1 
ATOM   3105 C C   . CYS B 2 201 ? 77.553  105.308 134.766 1.00 28.02 ? 194 CYS L C   1 
ATOM   3106 O O   . CYS B 2 201 ? 78.318  105.353 135.724 1.00 27.44 ? 194 CYS L O   1 
ATOM   3107 C CB  . CYS B 2 201 ? 79.281  104.910 133.022 1.00 29.28 ? 194 CYS L CB  1 
ATOM   3108 S SG  . CYS B 2 201 ? 78.966  103.144 132.907 1.00 33.34 ? 194 CYS L SG  1 
ATOM   3109 N N   . GLU B 2 202 ? 76.292  104.898 134.878 1.00 28.32 ? 195 GLU L N   1 
ATOM   3110 C CA  . GLU B 2 202 ? 75.742  104.477 136.181 1.00 30.10 ? 195 GLU L CA  1 
ATOM   3111 C C   . GLU B 2 202 ? 75.497  102.973 136.166 1.00 28.74 ? 195 GLU L C   1 
ATOM   3112 O O   . GLU B 2 202 ? 74.805  102.465 135.293 1.00 25.94 ? 195 GLU L O   1 
ATOM   3113 C CB  . GLU B 2 202 ? 74.455  105.225 136.532 1.00 33.54 ? 195 GLU L CB  1 
ATOM   3114 C CG  . GLU B 2 202 ? 73.871  104.879 137.908 1.00 35.51 ? 195 GLU L CG  1 
ATOM   3115 C CD  . GLU B 2 202 ? 72.410  105.286 138.028 1.00 38.88 ? 195 GLU L CD  1 
ATOM   3116 O OE1 . GLU B 2 202 ? 71.610  104.907 137.153 1.00 40.40 ? 195 GLU L OE1 1 
ATOM   3117 O OE2 . GLU B 2 202 ? 72.056  105.992 138.992 1.00 43.34 ? 195 GLU L OE2 1 
ATOM   3118 N N   . VAL B 2 203 ? 76.083  102.289 137.145 1.00 29.28 ? 196 VAL L N   1 
ATOM   3119 C CA  . VAL B 2 203 ? 76.096  100.822 137.214 1.00 30.35 ? 196 VAL L CA  1 
ATOM   3120 C C   . VAL B 2 203 ? 75.276  100.397 138.412 1.00 30.69 ? 196 VAL L C   1 
ATOM   3121 O O   . VAL B 2 203 ? 75.580  100.793 139.540 1.00 30.12 ? 196 VAL L O   1 
ATOM   3122 C CB  . VAL B 2 203 ? 77.526  100.266 137.397 1.00 30.29 ? 196 VAL L CB  1 
ATOM   3123 C CG1 . VAL B 2 203 ? 77.521  98.747  137.551 1.00 30.06 ? 196 VAL L CG1 1 
ATOM   3124 C CG2 . VAL B 2 203 ? 78.416  100.671 136.224 1.00 30.53 ? 196 VAL L CG2 1 
ATOM   3125 N N   . THR B 2 204 ? 74.254  99.584  138.171 1.00 30.69 ? 197 THR L N   1 
ATOM   3126 C CA  . THR B 2 204 ? 73.477  98.994  139.257 1.00 31.52 ? 197 THR L CA  1 
ATOM   3127 C C   . THR B 2 204 ? 73.842  97.511  139.361 1.00 31.72 ? 197 THR L C   1 
ATOM   3128 O O   . THR B 2 204 ? 73.810  96.782  138.368 1.00 30.89 ? 197 THR L O   1 
ATOM   3129 C CB  . THR B 2 204 ? 71.970  99.186  139.031 1.00 32.94 ? 197 THR L CB  1 
ATOM   3130 O OG1 . THR B 2 204 ? 71.705  100.577 138.770 1.00 32.98 ? 197 THR L OG1 1 
ATOM   3131 C CG2 . THR B 2 204 ? 71.188  98.759  140.262 1.00 33.44 ? 197 THR L CG2 1 
ATOM   3132 N N   . HIS B 2 205 ? 74.225  97.076  140.553 1.00 31.66 ? 198 HIS L N   1 
ATOM   3133 C CA  . HIS B 2 205 ? 74.652  95.695  140.747 1.00 33.13 ? 198 HIS L CA  1 
ATOM   3134 C C   . HIS B 2 205 ? 74.402  95.226  142.176 1.00 35.58 ? 198 HIS L C   1 
ATOM   3135 O O   . HIS B 2 205 ? 74.681  95.955  143.141 1.00 38.24 ? 198 HIS L O   1 
ATOM   3136 C CB  . HIS B 2 205 ? 76.129  95.506  140.365 1.00 31.70 ? 198 HIS L CB  1 
ATOM   3137 C CG  . HIS B 2 205 ? 76.548  94.067  140.312 1.00 32.02 ? 198 HIS L CG  1 
ATOM   3138 N ND1 . HIS B 2 205 ? 77.234  93.449  141.335 1.00 31.74 ? 198 HIS L ND1 1 
ATOM   3139 C CD2 . HIS B 2 205 ? 76.340  93.115  139.373 1.00 31.01 ? 198 HIS L CD2 1 
ATOM   3140 C CE1 . HIS B 2 205 ? 77.442  92.185  141.022 1.00 31.40 ? 198 HIS L CE1 1 
ATOM   3141 N NE2 . HIS B 2 205 ? 76.909  91.955  139.835 1.00 29.99 ? 198 HIS L NE2 1 
ATOM   3142 N N   . GLN B 2 206 ? 73.871  94.007  142.273 1.00 36.87 ? 199 GLN L N   1 
ATOM   3143 C CA  . GLN B 2 206 ? 73.528  93.314  143.529 1.00 40.03 ? 199 GLN L CA  1 
ATOM   3144 C C   . GLN B 2 206 ? 74.637  93.363  144.586 1.00 40.30 ? 199 GLN L C   1 
ATOM   3145 O O   . GLN B 2 206 ? 74.376  93.469  145.768 1.00 40.32 ? 199 GLN L O   1 
ATOM   3146 C CB  . GLN B 2 206 ? 73.207  91.861  143.172 1.00 41.98 ? 199 GLN L CB  1 
ATOM   3147 C CG  . GLN B 2 206 ? 72.965  90.888  144.304 1.00 44.41 ? 199 GLN L CG  1 
ATOM   3148 C CD  . GLN B 2 206 ? 72.509  89.536  143.776 1.00 43.30 ? 199 GLN L CD  1 
ATOM   3149 O OE1 . GLN B 2 206 ? 71.608  89.464  142.951 1.00 46.42 ? 199 GLN L OE1 1 
ATOM   3150 N NE2 . GLN B 2 206 ? 73.139  88.469  144.236 1.00 44.91 ? 199 GLN L NE2 1 
ATOM   3151 N N   . GLY B 2 207 ? 75.871  93.251  144.130 1.00 41.76 ? 200 GLY L N   1 
ATOM   3152 C CA  . GLY B 2 207 ? 77.055  93.435  144.962 1.00 42.55 ? 200 GLY L CA  1 
ATOM   3153 C C   . GLY B 2 207 ? 77.350  94.824  145.514 1.00 43.97 ? 200 GLY L C   1 
ATOM   3154 O O   . GLY B 2 207 ? 78.291  94.965  146.289 1.00 47.19 ? 200 GLY L O   1 
ATOM   3155 N N   . LEU B 2 208 ? 76.566  95.842  145.147 1.00 44.77 ? 201 LEU L N   1 
ATOM   3156 C CA  . LEU B 2 208 ? 76.788  97.231  145.597 1.00 45.13 ? 201 LEU L CA  1 
ATOM   3157 C C   . LEU B 2 208 ? 75.670  97.746  146.513 1.00 46.95 ? 201 LEU L C   1 
ATOM   3158 O O   . LEU B 2 208 ? 74.510  97.396  146.326 1.00 45.83 ? 201 LEU L O   1 
ATOM   3159 C CB  . LEU B 2 208 ? 76.887  98.163  144.387 1.00 45.50 ? 201 LEU L CB  1 
ATOM   3160 C CG  . LEU B 2 208 ? 78.124  98.066  143.490 1.00 46.62 ? 201 LEU L CG  1 
ATOM   3161 C CD1 . LEU B 2 208 ? 77.856  98.740  142.155 1.00 45.92 ? 201 LEU L CD1 1 
ATOM   3162 C CD2 . LEU B 2 208 ? 79.342  98.684  144.158 1.00 46.06 ? 201 LEU L CD2 1 
ATOM   3163 N N   . SER B 2 209 ? 76.021  98.598  147.482 1.00 50.58 ? 202 SER L N   1 
ATOM   3164 C CA  . SER B 2 209 ? 75.031  99.274  148.344 1.00 52.21 ? 202 SER L CA  1 
ATOM   3165 C C   . SER B 2 209 ? 73.982  100.036 147.544 1.00 52.11 ? 202 SER L C   1 
ATOM   3166 O O   . SER B 2 209 ? 72.806  100.040 147.895 1.00 56.99 ? 202 SER L O   1 
ATOM   3167 C CB  . SER B 2 209 ? 75.716  100.260 149.278 1.00 52.84 ? 202 SER L CB  1 
ATOM   3168 O OG  . SER B 2 209 ? 76.588  99.578  150.149 1.00 60.36 ? 202 SER L OG  1 
ATOM   3169 N N   . SER B 2 210 ? 74.426  100.690 146.478 1.00 50.39 ? 203 SER L N   1 
ATOM   3170 C CA  . SER B 2 210 ? 73.536  101.412 145.570 1.00 49.66 ? 203 SER L CA  1 
ATOM   3171 C C   . SER B 2 210 ? 74.298  101.697 144.275 1.00 47.62 ? 203 SER L C   1 
ATOM   3172 O O   . SER B 2 210 ? 75.489  101.396 144.197 1.00 45.92 ? 203 SER L O   1 
ATOM   3173 C CB  . SER B 2 210 ? 73.058  102.708 146.230 1.00 50.71 ? 203 SER L CB  1 
ATOM   3174 O OG  . SER B 2 210 ? 74.143  103.380 146.844 1.00 51.99 ? 203 SER L OG  1 
ATOM   3175 N N   . PRO B 2 211 ? 73.615  102.250 143.251 1.00 46.72 ? 204 PRO L N   1 
ATOM   3176 C CA  . PRO B 2 211 ? 74.302  102.469 141.982 1.00 46.47 ? 204 PRO L CA  1 
ATOM   3177 C C   . PRO B 2 211 ? 75.553  103.354 142.057 1.00 46.77 ? 204 PRO L C   1 
ATOM   3178 O O   . PRO B 2 211 ? 75.487  104.470 142.566 1.00 50.01 ? 204 PRO L O   1 
ATOM   3179 C CB  . PRO B 2 211 ? 73.230  103.136 141.119 1.00 46.53 ? 204 PRO L CB  1 
ATOM   3180 C CG  . PRO B 2 211 ? 71.955  102.604 141.638 1.00 45.66 ? 204 PRO L CG  1 
ATOM   3181 C CD  . PRO B 2 211 ? 72.150  102.374 143.104 1.00 46.06 ? 204 PRO L CD  1 
ATOM   3182 N N   . VAL B 2 212 ? 76.678  102.849 141.554 1.00 44.57 ? 205 VAL L N   1 
ATOM   3183 C CA  . VAL B 2 212 ? 77.885  103.678 141.401 1.00 43.65 ? 205 VAL L CA  1 
ATOM   3184 C C   . VAL B 2 212 ? 77.851  104.422 140.073 1.00 41.19 ? 205 VAL L C   1 
ATOM   3185 O O   . VAL B 2 212 ? 77.369  103.888 139.074 1.00 41.25 ? 205 VAL L O   1 
ATOM   3186 C CB  . VAL B 2 212 ? 79.217  102.890 141.503 1.00 44.80 ? 205 VAL L CB  1 
ATOM   3187 C CG1 . VAL B 2 212 ? 79.443  102.425 142.937 1.00 46.09 ? 205 VAL L CG1 1 
ATOM   3188 C CG2 . VAL B 2 212 ? 79.288  101.726 140.517 1.00 45.02 ? 205 VAL L CG2 1 
ATOM   3189 N N   . THR B 2 213 ? 78.368  105.651 140.085 1.00 37.98 ? 206 THR L N   1 
ATOM   3190 C CA  . THR B 2 213 ? 78.494  106.471 138.883 1.00 34.75 ? 206 THR L CA  1 
ATOM   3191 C C   . THR B 2 213 ? 79.949  106.851 138.710 1.00 34.89 ? 206 THR L C   1 
ATOM   3192 O O   . THR B 2 213 ? 80.622  107.237 139.668 1.00 31.91 ? 206 THR L O   1 
ATOM   3193 C CB  . THR B 2 213 ? 77.666  107.771 138.958 1.00 33.55 ? 206 THR L CB  1 
ATOM   3194 O OG1 . THR B 2 213 ? 76.281  107.448 139.056 1.00 33.47 ? 206 THR L OG1 1 
ATOM   3195 C CG2 . THR B 2 213 ? 77.878  108.642 137.712 1.00 33.85 ? 206 THR L CG2 1 
ATOM   3196 N N   . LYS B 2 214 ? 80.416  106.726 137.475 1.00 35.08 ? 207 LYS L N   1 
ATOM   3197 C CA  . LYS B 2 214 ? 81.679  107.280 137.058 1.00 35.24 ? 207 LYS L CA  1 
ATOM   3198 C C   . LYS B 2 214 ? 81.384  108.258 135.951 1.00 36.00 ? 207 LYS L C   1 
ATOM   3199 O O   . LYS B 2 214 ? 80.687  107.937 134.969 1.00 32.12 ? 207 LYS L O   1 
ATOM   3200 C CB  . LYS B 2 214 ? 82.621  106.204 136.524 1.00 36.21 ? 207 LYS L CB  1 
ATOM   3201 C CG  . LYS B 2 214 ? 82.974  105.140 137.537 1.00 38.59 ? 207 LYS L CG  1 
ATOM   3202 C CD  . LYS B 2 214 ? 83.736  105.710 138.720 1.00 40.12 ? 207 LYS L CD  1 
ATOM   3203 C CE  . LYS B 2 214 ? 84.067  104.609 139.697 1.00 42.40 ? 207 LYS L CE  1 
ATOM   3204 N NZ  . LYS B 2 214 ? 84.917  105.098 140.809 1.00 43.58 ? 207 LYS L NZ  1 
ATOM   3205 N N   . SER B 2 215 ? 81.952  109.443 136.100 1.00 35.64 ? 208 SER L N   1 
ATOM   3206 C CA  . SER B 2 215 ? 81.798  110.472 135.115 1.00 35.51 ? 208 SER L CA  1 
ATOM   3207 C C   . SER B 2 215 ? 83.107  111.133 134.806 1.00 34.57 ? 208 SER L C   1 
ATOM   3208 O O   . SER B 2 215 ? 84.127  110.936 135.472 1.00 33.55 ? 208 SER L O   1 
ATOM   3209 C CB  . SER B 2 215 ? 80.762  111.507 135.572 1.00 36.83 ? 208 SER L CB  1 
ATOM   3210 O OG  . SER B 2 215 ? 80.876  111.778 136.951 1.00 35.43 ? 208 SER L OG  1 
ATOM   3211 N N   . PHE B 2 216 ? 83.058  111.884 133.726 1.00 34.78 ? 209 PHE L N   1 
ATOM   3212 C CA  . PHE B 2 216 ? 84.058  112.872 133.432 1.00 34.72 ? 209 PHE L CA  1 
ATOM   3213 C C   . PHE B 2 216 ? 83.346  114.062 132.795 1.00 35.68 ? 209 PHE L C   1 
ATOM   3214 O O   . PHE B 2 216 ? 82.277  113.920 132.208 1.00 34.49 ? 209 PHE L O   1 
ATOM   3215 C CB  . PHE B 2 216 ? 85.142  112.293 132.527 1.00 32.49 ? 209 PHE L CB  1 
ATOM   3216 C CG  . PHE B 2 216 ? 84.667  111.915 131.158 1.00 30.53 ? 209 PHE L CG  1 
ATOM   3217 C CD1 . PHE B 2 216 ? 84.695  112.836 130.128 1.00 30.70 ? 209 PHE L CD1 1 
ATOM   3218 C CD2 . PHE B 2 216 ? 84.211  110.629 130.888 1.00 30.05 ? 209 PHE L CD2 1 
ATOM   3219 C CE1 . PHE B 2 216 ? 84.270  112.494 128.856 1.00 30.19 ? 209 PHE L CE1 1 
ATOM   3220 C CE2 . PHE B 2 216 ? 83.799  110.271 129.613 1.00 28.70 ? 209 PHE L CE2 1 
ATOM   3221 C CZ  . PHE B 2 216 ? 83.827  111.206 128.597 1.00 29.38 ? 209 PHE L CZ  1 
ATOM   3222 N N   . ASN B 2 217 ? 83.920  115.237 132.996 1.00 39.40 ? 210 ASN L N   1 
ATOM   3223 C CA  . ASN B 2 217 ? 83.541  116.438 132.275 1.00 42.46 ? 210 ASN L CA  1 
ATOM   3224 C C   . ASN B 2 217 ? 84.558  116.587 131.183 1.00 43.03 ? 210 ASN L C   1 
ATOM   3225 O O   . ASN B 2 217 ? 85.742  116.376 131.426 1.00 42.87 ? 210 ASN L O   1 
ATOM   3226 C CB  . ASN B 2 217 ? 83.650  117.669 133.173 1.00 45.05 ? 210 ASN L CB  1 
ATOM   3227 C CG  . ASN B 2 217 ? 82.500  117.802 134.161 1.00 48.55 ? 210 ASN L CG  1 
ATOM   3228 O OD1 . ASN B 2 217 ? 82.041  118.911 134.419 1.00 52.36 ? 210 ASN L OD1 1 
ATOM   3229 N ND2 . ASN B 2 217 ? 82.041  116.697 134.737 1.00 48.92 ? 210 ASN L ND2 1 
ATOM   3230 N N   . ARG B 2 218 ? 84.128  116.942 129.983 1.00 45.24 ? 211 ARG L N   1 
ATOM   3231 C CA  . ARG B 2 218 ? 85.094  117.436 128.999 1.00 47.99 ? 211 ARG L CA  1 
ATOM   3232 C C   . ARG B 2 218 ? 85.028  118.954 128.996 1.00 48.88 ? 211 ARG L C   1 
ATOM   3233 O O   . ARG B 2 218 ? 85.949  119.610 128.536 1.00 52.72 ? 211 ARG L O   1 
ATOM   3234 C CB  . ARG B 2 218 ? 84.863  116.865 127.607 1.00 46.57 ? 211 ARG L CB  1 
ATOM   3235 C CG  . ARG B 2 218 ? 83.451  116.961 127.093 1.00 47.51 ? 211 ARG L CG  1 
ATOM   3236 C CD  . ARG B 2 218 ? 83.444  116.765 125.592 1.00 48.84 ? 211 ARG L CD  1 
ATOM   3237 N NE  . ARG B 2 218 ? 83.941  117.933 124.878 1.00 51.34 ? 211 ARG L NE  1 
ATOM   3238 C CZ  . ARG B 2 218 ? 83.271  119.073 124.709 1.00 52.85 ? 211 ARG L CZ  1 
ATOM   3239 N NH1 . ARG B 2 218 ? 82.050  119.233 125.189 1.00 54.60 ? 211 ARG L NH1 1 
ATOM   3240 N NH2 . ARG B 2 218 ? 83.831  120.071 124.045 1.00 55.40 ? 211 ARG L NH2 1 
HETATM 3241 C C   . ACT C 3 .   ? 74.603  76.441  94.399  1.00 47.64 ? 301 ACT H C   1 
HETATM 3242 O O   . ACT C 3 .   ? 74.512  75.234  94.003  1.00 44.46 ? 301 ACT H O   1 
HETATM 3243 O OXT . ACT C 3 .   ? 75.395  76.815  95.302  1.00 48.27 ? 301 ACT H OXT 1 
HETATM 3244 C CH3 . ACT C 3 .   ? 73.789  77.528  93.768  1.00 44.50 ? 301 ACT H CH3 1 
HETATM 3245 C C   . ACT D 3 .   ? 62.753  60.100  115.685 1.00 57.43 ? 301 ACT L C   1 
HETATM 3246 O O   . ACT D 3 .   ? 62.243  61.000  114.980 1.00 58.69 ? 301 ACT L O   1 
HETATM 3247 O OXT . ACT D 3 .   ? 62.099  59.116  116.098 1.00 58.04 ? 301 ACT L OXT 1 
HETATM 3248 C CH3 . ACT D 3 .   ? 64.204  60.211  116.036 1.00 56.48 ? 301 ACT L CH3 1 
HETATM 3249 O O   . HOH E 4 .   ? 67.886  79.608  114.864 1.00 22.77 ? 401 HOH H O   1 
HETATM 3250 O O   . HOH E 4 .   ? 80.737  101.947 111.946 1.00 28.28 ? 402 HOH H O   1 
HETATM 3251 O O   . HOH E 4 .   ? 80.862  83.325  108.558 1.00 24.47 ? 403 HOH H O   1 
HETATM 3252 O O   . HOH E 4 .   ? 80.461  76.054  103.985 1.00 24.32 ? 404 HOH H O   1 
HETATM 3253 O O   . HOH E 4 .   ? 86.160  89.848  116.356 1.00 20.00 ? 405 HOH H O   1 
HETATM 3254 O O   . HOH E 4 .   ? 91.217  92.868  134.743 1.00 31.26 ? 406 HOH H O   1 
HETATM 3255 O O   . HOH E 4 .   ? 78.003  93.328  108.687 1.00 30.15 ? 407 HOH H O   1 
HETATM 3256 O O   . HOH E 4 .   ? 92.973  88.832  123.686 1.00 30.58 ? 408 HOH H O   1 
HETATM 3257 O O   . HOH E 4 .   ? 85.787  78.343  108.258 1.00 47.03 ? 409 HOH H O   1 
HETATM 3258 O O   . HOH E 4 .   ? 66.121  67.186  98.002  1.00 9.89  ? 410 HOH H O   1 
HETATM 3259 O O   . HOH E 4 .   ? 81.477  68.814  98.151  1.00 41.25 ? 411 HOH H O   1 
HETATM 3260 O O   . HOH E 4 .   ? 71.720  67.039  103.308 1.00 16.62 ? 412 HOH H O   1 
HETATM 3261 O O   . HOH E 4 .   ? 86.561  65.259  110.899 1.00 34.22 ? 413 HOH H O   1 
HETATM 3262 O O   . HOH E 4 .   ? 106.110 86.742  122.980 1.00 48.19 ? 414 HOH H O   1 
HETATM 3263 O O   . HOH E 4 .   ? 83.925  88.462  118.855 1.00 30.89 ? 415 HOH H O   1 
HETATM 3264 O O   . HOH E 4 .   ? 65.436  81.038  112.115 1.00 21.27 ? 416 HOH H O   1 
HETATM 3265 O O   . HOH E 4 .   ? 73.809  59.183  106.796 1.00 31.16 ? 417 HOH H O   1 
HETATM 3266 O O   . HOH E 4 .   ? 84.453  78.632  103.168 1.00 49.94 ? 418 HOH H O   1 
HETATM 3267 O O   . HOH E 4 .   ? 84.037  55.520  106.557 1.00 42.48 ? 419 HOH H O   1 
HETATM 3268 O O   . HOH E 4 .   ? 71.312  70.791  98.502  1.00 27.99 ? 420 HOH H O   1 
HETATM 3269 O O   . HOH E 4 .   ? 78.333  59.833  116.183 1.00 33.85 ? 421 HOH H O   1 
HETATM 3270 O O   . HOH E 4 .   ? 97.062  89.881  117.917 1.00 22.33 ? 422 HOH H O   1 
HETATM 3271 O O   . HOH E 4 .   ? 78.477  90.760  120.995 1.00 32.44 ? 423 HOH H O   1 
HETATM 3272 O O   . HOH E 4 .   ? 102.556 102.637 127.855 1.00 36.04 ? 424 HOH H O   1 
HETATM 3273 O O   . HOH E 4 .   ? 67.701  75.995  98.788  1.00 22.84 ? 425 HOH H O   1 
HETATM 3274 O O   . HOH E 4 .   ? 84.069  59.108  103.678 1.00 43.68 ? 426 HOH H O   1 
HETATM 3275 O O   . HOH E 4 .   ? 78.158  88.908  113.684 1.00 35.63 ? 427 HOH H O   1 
HETATM 3276 O O   . HOH E 4 .   ? 86.218  58.309  110.296 1.00 50.31 ? 428 HOH H O   1 
HETATM 3277 O O   . HOH E 4 .   ? 69.974  85.029  112.588 1.00 42.29 ? 429 HOH H O   1 
HETATM 3278 O O   . HOH E 4 .   ? 68.864  55.364  105.249 1.00 30.26 ? 430 HOH H O   1 
HETATM 3279 O O   . HOH E 4 .   ? 81.742  56.021  98.189  1.00 25.75 ? 431 HOH H O   1 
HETATM 3280 O O   . HOH E 4 .   ? 97.882  106.348 124.822 1.00 33.19 ? 432 HOH H O   1 
HETATM 3281 O O   . HOH E 4 .   ? 69.433  83.237  96.352  1.00 31.05 ? 433 HOH H O   1 
HETATM 3282 O O   . HOH E 4 .   ? 64.066  68.526  99.186  1.00 17.36 ? 434 HOH H O   1 
HETATM 3283 O O   . HOH E 4 .   ? 78.148  72.627  106.643 1.00 21.66 ? 435 HOH H O   1 
HETATM 3284 O O   . HOH E 4 .   ? 81.682  56.664  104.215 1.00 44.52 ? 436 HOH H O   1 
HETATM 3285 O O   . HOH E 4 .   ? 97.447  90.369  109.336 1.00 39.57 ? 437 HOH H O   1 
HETATM 3286 O O   . HOH E 4 .   ? 88.522  87.531  129.819 1.00 33.92 ? 438 HOH H O   1 
HETATM 3287 O O   . HOH E 4 .   ? 87.409  85.488  109.017 1.00 31.52 ? 439 HOH H O   1 
HETATM 3288 O O   . HOH E 4 .   ? 68.027  80.205  107.953 1.00 18.92 ? 440 HOH H O   1 
HETATM 3289 O O   . HOH E 4 .   ? 89.867  88.434  103.699 1.00 41.24 ? 441 HOH H O   1 
HETATM 3290 O O   . HOH E 4 .   ? 58.307  64.824  103.653 1.00 31.27 ? 442 HOH H O   1 
HETATM 3291 O O   . HOH E 4 .   ? 94.493  87.496  114.186 1.00 37.70 ? 443 HOH H O   1 
HETATM 3292 O O   . HOH E 4 .   ? 71.313  88.502  112.094 1.00 39.90 ? 444 HOH H O   1 
HETATM 3293 O O   . HOH E 4 .   ? 82.101  88.566  110.879 1.00 25.99 ? 445 HOH H O   1 
HETATM 3294 O O   . HOH E 4 .   ? 85.277  69.095  112.343 1.00 29.42 ? 446 HOH H O   1 
HETATM 3295 O O   . HOH E 4 .   ? 87.690  98.396  102.708 1.00 45.35 ? 447 HOH H O   1 
HETATM 3296 O O   . HOH E 4 .   ? 78.087  76.199  95.533  1.00 45.31 ? 448 HOH H O   1 
HETATM 3297 O O   . HOH E 4 .   ? 83.531  67.152  113.257 1.00 33.85 ? 449 HOH H O   1 
HETATM 3298 O O   . HOH E 4 .   ? 82.819  73.295  116.784 1.00 22.73 ? 450 HOH H O   1 
HETATM 3299 O O   . HOH E 4 .   ? 73.483  59.606  110.408 1.00 35.73 ? 451 HOH H O   1 
HETATM 3300 O O   . HOH E 4 .   ? 82.353  78.004  110.066 1.00 23.23 ? 452 HOH H O   1 
HETATM 3301 O O   . HOH E 4 .   ? 78.984  72.999  99.120  1.00 39.30 ? 453 HOH H O   1 
HETATM 3302 O O   . HOH E 4 .   ? 74.070  68.421  95.651  1.00 25.97 ? 454 HOH H O   1 
HETATM 3303 O O   . HOH E 4 .   ? 69.712  52.757  98.350  1.00 48.22 ? 455 HOH H O   1 
HETATM 3304 O O   . HOH E 4 .   ? 73.679  104.089 112.964 1.00 47.45 ? 456 HOH H O   1 
HETATM 3305 O O   . HOH E 4 .   ? 77.012  84.518  111.407 1.00 38.58 ? 457 HOH H O   1 
HETATM 3306 O O   . HOH E 4 .   ? 98.540  98.282  110.030 1.00 35.96 ? 458 HOH H O   1 
HETATM 3307 O O   . HOH E 4 .   ? 63.347  74.591  118.339 1.00 27.40 ? 459 HOH H O   1 
HETATM 3308 O O   . HOH E 4 .   ? 84.172  62.664  107.774 1.00 36.28 ? 460 HOH H O   1 
HETATM 3309 O O   . HOH E 4 .   ? 87.715  88.784  118.229 1.00 16.45 ? 461 HOH H O   1 
HETATM 3310 O O   . HOH E 4 .   ? 69.387  85.876  115.241 1.00 33.85 ? 462 HOH H O   1 
HETATM 3311 O O   . HOH E 4 .   ? 85.276  92.641  100.532 1.00 62.70 ? 463 HOH H O   1 
HETATM 3312 O O   . HOH E 4 .   ? 61.601  77.904  116.054 1.00 30.43 ? 464 HOH H O   1 
HETATM 3313 O O   . HOH E 4 .   ? 77.050  51.829  109.884 1.00 46.50 ? 465 HOH H O   1 
HETATM 3314 O O   . HOH E 4 .   ? 76.462  92.277  118.002 1.00 29.97 ? 466 HOH H O   1 
HETATM 3315 O O   . HOH E 4 .   ? 89.857  87.634  127.131 1.00 31.91 ? 467 HOH H O   1 
HETATM 3316 O O   . HOH E 4 .   ? 80.136  74.904  117.002 1.00 31.46 ? 468 HOH H O   1 
HETATM 3317 O O   . HOH E 4 .   ? 85.182  74.687  103.200 1.00 29.76 ? 469 HOH H O   1 
HETATM 3318 O O   . HOH E 4 .   ? 62.621  72.685  100.954 1.00 29.98 ? 470 HOH H O   1 
HETATM 3319 O O   . HOH E 4 .   ? 60.788  63.843  100.084 1.00 35.08 ? 471 HOH H O   1 
HETATM 3320 O O   . HOH E 4 .   ? 96.753  88.991  106.187 1.00 46.88 ? 472 HOH H O   1 
HETATM 3321 O O   . HOH E 4 .   ? 71.569  81.091  120.418 1.00 35.72 ? 473 HOH H O   1 
HETATM 3322 O O   . HOH E 4 .   ? 70.481  64.607  96.635  1.00 29.49 ? 474 HOH H O   1 
HETATM 3323 O O   . HOH E 4 .   ? 84.848  59.282  98.167  1.00 41.98 ? 475 HOH H O   1 
HETATM 3324 O O   . HOH E 4 .   ? 77.560  83.119  97.355  1.00 52.45 ? 476 HOH H O   1 
HETATM 3325 O O   . HOH E 4 .   ? 92.353  88.008  112.430 1.00 29.18 ? 477 HOH H O   1 
HETATM 3326 O O   . HOH E 4 .   ? 74.195  83.339  94.836  1.00 43.84 ? 478 HOH H O   1 
HETATM 3327 O O   . HOH E 4 .   ? 67.266  88.567  100.692 1.00 45.75 ? 479 HOH H O   1 
HETATM 3328 O O   . HOH E 4 .   ? 66.853  64.515  97.781  1.00 28.64 ? 480 HOH H O   1 
HETATM 3329 O O   . HOH E 4 .   ? 78.008  90.965  109.807 1.00 28.45 ? 481 HOH H O   1 
HETATM 3330 O O   . HOH E 4 .   ? 72.314  50.351  109.253 1.00 50.63 ? 482 HOH H O   1 
HETATM 3331 O O   . HOH E 4 .   ? 67.431  83.743  113.439 1.00 34.54 ? 483 HOH H O   1 
HETATM 3332 O O   . HOH E 4 .   ? 81.148  64.566  114.349 1.00 34.44 ? 484 HOH H O   1 
HETATM 3333 O O   . HOH E 4 .   ? 85.440  85.835  116.194 1.00 28.69 ? 485 HOH H O   1 
HETATM 3334 O O   . HOH E 4 .   ? 99.709  103.512 130.431 1.00 33.24 ? 486 HOH H O   1 
HETATM 3335 O O   . HOH E 4 .   ? 80.208  104.469 115.031 1.00 32.43 ? 487 HOH H O   1 
HETATM 3336 O O   . HOH E 4 .   ? 83.255  77.695  100.723 1.00 43.82 ? 488 HOH H O   1 
HETATM 3337 O O   . HOH E 4 .   ? 72.636  72.984  94.586  1.00 33.20 ? 489 HOH H O   1 
HETATM 3338 O O   . HOH E 4 .   ? 78.279  78.166  98.527  1.00 36.50 ? 490 HOH H O   1 
HETATM 3339 O O   . HOH E 4 .   ? 82.103  82.717  101.466 1.00 33.50 ? 491 HOH H O   1 
HETATM 3340 O O   . HOH E 4 .   ? 68.284  56.771  111.358 1.00 21.58 ? 492 HOH H O   1 
HETATM 3341 O O   . HOH E 4 .   ? 70.947  78.542  121.439 1.00 18.94 ? 493 HOH H O   1 
HETATM 3342 O O   . HOH E 4 .   ? 68.256  59.321  115.382 1.00 40.95 ? 494 HOH H O   1 
HETATM 3343 O O   . HOH E 4 .   ? 88.843  55.695  114.283 1.00 51.65 ? 495 HOH H O   1 
HETATM 3344 O O   . HOH E 4 .   ? 56.346  64.358  109.233 1.00 54.17 ? 496 HOH H O   1 
HETATM 3345 O O   . HOH E 4 .   ? 61.576  58.123  98.473  1.00 46.37 ? 497 HOH H O   1 
HETATM 3346 O O   . HOH E 4 .   ? 77.828  56.550  94.642  1.00 46.67 ? 498 HOH H O   1 
HETATM 3347 O O   . HOH E 4 .   ? 97.367  94.849  139.160 1.00 41.92 ? 499 HOH H O   1 
HETATM 3348 O O   . HOH E 4 .   ? 74.181  60.554  95.250  1.00 32.98 ? 500 HOH H O   1 
HETATM 3349 O O   . HOH E 4 .   ? 104.627 95.049  121.865 1.00 31.99 ? 501 HOH H O   1 
HETATM 3350 O O   . HOH E 4 .   ? 61.113  75.331  115.069 1.00 26.16 ? 502 HOH H O   1 
HETATM 3351 O O   . HOH E 4 .   ? 90.696  98.718  105.199 1.00 38.16 ? 503 HOH H O   1 
HETATM 3352 O O   . HOH E 4 .   ? 83.523  95.025  123.130 1.00 28.49 ? 504 HOH H O   1 
HETATM 3353 O O   . HOH E 4 .   ? 68.457  90.696  99.079  1.00 48.34 ? 505 HOH H O   1 
HETATM 3354 O O   . HOH E 4 .   ? 73.305  92.416  98.242  1.00 43.85 ? 506 HOH H O   1 
HETATM 3355 O O   . HOH E 4 .   ? 67.793  88.967  111.730 1.00 53.20 ? 507 HOH H O   1 
HETATM 3356 O O   . HOH E 4 .   ? 68.431  54.486  118.285 1.00 45.26 ? 508 HOH H O   1 
HETATM 3357 O O   . HOH E 4 .   ? 76.056  63.595  93.074  1.00 49.16 ? 509 HOH H O   1 
HETATM 3358 O O   . HOH E 4 .   ? 96.129  103.332 114.880 1.00 46.08 ? 510 HOH H O   1 
HETATM 3359 O O   . HOH E 4 .   ? 66.324  59.111  117.980 1.00 49.27 ? 511 HOH H O   1 
HETATM 3360 O O   . HOH E 4 .   ? 66.689  62.309  115.357 1.00 37.70 ? 512 HOH H O   1 
HETATM 3361 O O   . HOH E 4 .   ? 78.427  71.131  95.505  1.00 39.49 ? 513 HOH H O   1 
HETATM 3362 O O   . HOH E 4 .   ? 77.519  86.020  97.891  1.00 38.28 ? 514 HOH H O   1 
HETATM 3363 O O   . HOH E 4 .   ? 85.568  49.019  111.798 1.00 52.22 ? 515 HOH H O   1 
HETATM 3364 O O   . HOH E 4 .   ? 60.379  70.851  100.909 1.00 40.48 ? 516 HOH H O   1 
HETATM 3365 O O   . HOH E 4 .   ? 85.483  84.743  113.614 1.00 36.06 ? 517 HOH H O   1 
HETATM 3366 O O   . HOH E 4 .   ? 82.757  52.965  107.258 1.00 50.58 ? 518 HOH H O   1 
HETATM 3367 O O   . HOH E 4 .   ? 91.784  103.756 136.708 1.00 32.30 ? 519 HOH H O   1 
HETATM 3368 O O   . HOH E 4 .   ? 86.517  55.794  108.747 1.00 46.27 ? 520 HOH H O   1 
HETATM 3369 O O   . HOH E 4 .   ? 96.312  90.168  103.274 1.00 50.14 ? 521 HOH H O   1 
HETATM 3370 O O   . HOH E 4 .   ? 63.552  63.095  95.954  1.00 31.73 ? 522 HOH H O   1 
HETATM 3371 O O   . HOH E 4 .   ? 104.326 104.712 129.318 1.00 46.11 ? 523 HOH H O   1 
HETATM 3372 O O   . HOH E 4 .   ? 88.289  50.111  111.684 1.00 48.51 ? 524 HOH H O   1 
HETATM 3373 O O   . HOH E 4 .   ? 81.991  98.497  104.726 1.00 38.32 ? 525 HOH H O   1 
HETATM 3374 O O   . HOH E 4 .   ? 65.037  57.185  111.400 1.00 40.21 ? 526 HOH H O   1 
HETATM 3375 O O   . HOH E 4 .   ? 66.605  55.833  120.125 1.00 49.07 ? 527 HOH H O   1 
HETATM 3376 O O   . HOH E 4 .   ? 81.347  77.106  115.662 1.00 37.45 ? 528 HOH H O   1 
HETATM 3377 O O   . HOH E 4 .   ? 69.097  88.613  119.447 1.00 45.31 ? 529 HOH H O   1 
HETATM 3378 O O   . HOH E 4 .   ? 68.511  50.905  100.175 1.00 48.07 ? 530 HOH H O   1 
HETATM 3379 O O   . HOH E 4 .   ? 63.350  59.170  111.395 1.00 44.18 ? 531 HOH H O   1 
HETATM 3380 O O   . HOH E 4 .   ? 80.040  65.753  119.219 1.00 47.08 ? 532 HOH H O   1 
HETATM 3381 O O   . HOH E 4 .   ? 75.203  94.085  109.001 1.00 51.16 ? 533 HOH H O   1 
HETATM 3382 O O   . HOH E 4 .   ? 85.690  83.331  109.771 1.00 35.30 ? 534 HOH H O   1 
HETATM 3383 O O   . HOH E 4 .   ? 86.587  58.133  105.082 1.00 43.06 ? 535 HOH H O   1 
HETATM 3384 O O   . HOH E 4 .   ? 87.220  83.129  112.218 1.00 34.25 ? 536 HOH H O   1 
HETATM 3385 O O   . HOH E 4 .   ? 67.817  65.932  115.713 1.00 38.08 ? 537 HOH H O   1 
HETATM 3386 O O   . HOH E 4 .   ? 83.091  82.932  110.254 1.00 28.66 ? 538 HOH H O   1 
HETATM 3387 O O   . HOH E 4 .   ? 70.182  72.415  96.091  1.00 39.79 ? 539 HOH H O   1 
HETATM 3388 O O   . HOH E 4 .   ? 87.439  86.085  106.362 1.00 35.20 ? 540 HOH H O   1 
HETATM 3389 O O   . HOH E 4 .   ? 81.372  101.451 106.077 1.00 36.22 ? 541 HOH H O   1 
HETATM 3390 O O   . HOH E 4 .   ? 85.784  87.011  103.969 1.00 35.39 ? 542 HOH H O   1 
HETATM 3391 O O   . HOH F 4 .   ? 77.026  85.034  145.383 1.00 30.66 ? 401 HOH L O   1 
HETATM 3392 O O   . HOH F 4 .   ? 75.061  64.243  144.076 1.00 38.40 ? 402 HOH L O   1 
HETATM 3393 O O   . HOH F 4 .   ? 73.000  61.784  137.881 1.00 27.71 ? 403 HOH L O   1 
HETATM 3394 O O   . HOH F 4 .   ? 84.768  79.653  137.380 1.00 30.40 ? 404 HOH L O   1 
HETATM 3395 O O   . HOH F 4 .   ? 51.867  72.600  122.198 1.00 22.20 ? 405 HOH L O   1 
HETATM 3396 O O   . HOH F 4 .   ? 77.719  102.048 120.729 1.00 22.37 ? 406 HOH L O   1 
HETATM 3397 O O   . HOH F 4 .   ? 58.560  55.992  126.805 1.00 22.92 ? 407 HOH L O   1 
HETATM 3398 O O   . HOH F 4 .   ? 73.460  81.065  137.434 1.00 42.36 ? 408 HOH L O   1 
HETATM 3399 O O   . HOH F 4 .   ? 51.846  61.218  123.052 1.00 40.94 ? 409 HOH L O   1 
HETATM 3400 O O   . HOH F 4 .   ? 78.364  99.594  147.706 1.00 40.97 ? 410 HOH L O   1 
HETATM 3401 O O   . HOH F 4 .   ? 85.501  65.350  132.968 1.00 33.28 ? 411 HOH L O   1 
HETATM 3402 O O   . HOH F 4 .   ? 69.411  101.578 139.376 1.00 43.19 ? 412 HOH L O   1 
HETATM 3403 O O   . HOH F 4 .   ? 56.677  70.224  117.074 1.00 16.47 ? 413 HOH L O   1 
HETATM 3404 O O   . HOH F 4 .   ? 75.035  99.378  127.865 1.00 25.47 ? 414 HOH L O   1 
HETATM 3405 O O   . HOH F 4 .   ? 79.208  85.195  129.625 1.00 32.13 ? 415 HOH L O   1 
HETATM 3406 O O   . HOH F 4 .   ? 56.588  74.210  127.371 1.00 23.91 ? 416 HOH L O   1 
HETATM 3407 O O   . HOH F 4 .   ? 72.389  101.557 136.451 1.00 26.47 ? 417 HOH L O   1 
HETATM 3408 O O   . HOH F 4 .   ? 59.706  50.923  120.588 1.00 20.61 ? 418 HOH L O   1 
HETATM 3409 O O   . HOH F 4 .   ? 73.479  91.760  140.234 1.00 41.43 ? 419 HOH L O   1 
HETATM 3410 O O   . HOH F 4 .   ? 72.770  96.963  131.178 1.00 38.00 ? 420 HOH L O   1 
HETATM 3411 O O   . HOH F 4 .   ? 61.375  64.763  135.761 1.00 35.79 ? 421 HOH L O   1 
HETATM 3412 O O   . HOH F 4 .   ? 81.145  66.325  131.148 1.00 43.03 ? 422 HOH L O   1 
HETATM 3413 O O   . HOH F 4 .   ? 65.778  78.470  128.641 1.00 22.06 ? 423 HOH L O   1 
HETATM 3414 O O   . HOH F 4 .   ? 66.923  62.810  136.458 1.00 36.82 ? 424 HOH L O   1 
HETATM 3415 O O   . HOH F 4 .   ? 74.589  83.365  141.612 1.00 33.12 ? 425 HOH L O   1 
HETATM 3416 O O   . HOH F 4 .   ? 78.085  89.765  125.556 1.00 30.29 ? 426 HOH L O   1 
HETATM 3417 O O   . HOH F 4 .   ? 79.359  76.991  119.939 1.00 32.65 ? 427 HOH L O   1 
HETATM 3418 O O   . HOH F 4 .   ? 85.568  87.108  132.802 1.00 27.41 ? 428 HOH L O   1 
HETATM 3419 O O   . HOH F 4 .   ? 80.755  85.848  126.325 1.00 32.22 ? 429 HOH L O   1 
HETATM 3420 O O   . HOH F 4 .   ? 74.473  95.462  123.478 1.00 24.80 ? 430 HOH L O   1 
HETATM 3421 O O   . HOH F 4 .   ? 60.782  73.291  133.112 1.00 33.87 ? 431 HOH L O   1 
HETATM 3422 O O   . HOH F 4 .   ? 72.049  64.111  118.338 1.00 31.39 ? 432 HOH L O   1 
HETATM 3423 O O   . HOH F 4 .   ? 87.296  78.757  139.845 1.00 52.37 ? 433 HOH L O   1 
HETATM 3424 O O   . HOH F 4 .   ? 79.071  99.967  119.834 1.00 36.14 ? 434 HOH L O   1 
HETATM 3425 O O   . HOH F 4 .   ? 50.764  52.645  120.875 1.00 46.27 ? 435 HOH L O   1 
HETATM 3426 O O   . HOH F 4 .   ? 78.168  77.082  126.064 1.00 28.77 ? 436 HOH L O   1 
HETATM 3427 O O   . HOH F 4 .   ? 70.526  79.422  126.617 1.00 36.39 ? 437 HOH L O   1 
HETATM 3428 O O   . HOH F 4 .   ? 75.403  85.037  137.478 1.00 29.55 ? 438 HOH L O   1 
HETATM 3429 O O   . HOH F 4 .   ? 71.813  104.040 129.081 1.00 44.01 ? 439 HOH L O   1 
HETATM 3430 O O   . HOH F 4 .   ? 54.941  64.421  113.709 1.00 32.23 ? 440 HOH L O   1 
HETATM 3431 O O   . HOH F 4 .   ? 84.503  74.945  125.230 1.00 45.55 ? 441 HOH L O   1 
HETATM 3432 O O   . HOH F 4 .   ? 79.059  78.094  132.397 1.00 32.86 ? 442 HOH L O   1 
HETATM 3433 O O   . HOH F 4 .   ? 61.915  58.497  135.145 1.00 40.34 ? 443 HOH L O   1 
HETATM 3434 O O   . HOH F 4 .   ? 75.340  90.589  131.747 1.00 29.93 ? 444 HOH L O   1 
HETATM 3435 O O   . HOH F 4 .   ? 72.918  100.800 119.215 1.00 32.61 ? 445 HOH L O   1 
HETATM 3436 O O   . HOH F 4 .   ? 91.682  85.416  136.954 1.00 26.55 ? 446 HOH L O   1 
HETATM 3437 O O   . HOH F 4 .   ? 67.327  76.949  121.810 1.00 14.12 ? 447 HOH L O   1 
HETATM 3438 O O   . HOH F 4 .   ? 52.477  54.485  122.925 1.00 26.63 ? 448 HOH L O   1 
HETATM 3439 O O   . HOH F 4 .   ? 85.987  88.750  134.870 1.00 24.39 ? 449 HOH L O   1 
HETATM 3440 O O   . HOH F 4 .   ? 72.367  103.937 125.534 1.00 34.20 ? 450 HOH L O   1 
HETATM 3441 O O   . HOH F 4 .   ? 71.431  54.333  130.154 1.00 45.19 ? 451 HOH L O   1 
HETATM 3442 O O   . HOH F 4 .   ? 86.604  69.952  137.699 1.00 39.25 ? 452 HOH L O   1 
HETATM 3443 O O   . HOH F 4 .   ? 74.189  117.335 115.897 1.00 35.97 ? 453 HOH L O   1 
HETATM 3444 O O   . HOH F 4 .   ? 71.358  100.869 123.514 1.00 28.77 ? 454 HOH L O   1 
HETATM 3445 O O   . HOH F 4 .   ? 88.339  86.310  132.268 1.00 39.82 ? 455 HOH L O   1 
HETATM 3446 O O   . HOH F 4 .   ? 53.431  50.314  120.912 1.00 29.42 ? 456 HOH L O   1 
HETATM 3447 O O   . HOH F 4 .   ? 68.988  79.052  139.867 1.00 34.83 ? 457 HOH L O   1 
HETATM 3448 O O   . HOH F 4 .   ? 69.275  69.485  142.962 1.00 36.56 ? 458 HOH L O   1 
HETATM 3449 O O   . HOH F 4 .   ? 62.879  73.543  115.499 1.00 26.59 ? 459 HOH L O   1 
HETATM 3450 O O   . HOH F 4 .   ? 63.369  76.795  127.500 1.00 31.29 ? 460 HOH L O   1 
HETATM 3451 O O   . HOH F 4 .   ? 73.610  98.812  125.568 1.00 40.92 ? 461 HOH L O   1 
HETATM 3452 O O   . HOH F 4 .   ? 79.777  70.757  123.847 1.00 22.11 ? 462 HOH L O   1 
HETATM 3453 O O   . HOH F 4 .   ? 82.246  93.419  146.361 1.00 39.95 ? 463 HOH L O   1 
HETATM 3454 O O   . HOH F 4 .   ? 88.567  82.123  131.769 1.00 37.53 ? 464 HOH L O   1 
HETATM 3455 O O   . HOH F 4 .   ? 59.492  60.174  115.597 1.00 50.70 ? 465 HOH L O   1 
HETATM 3456 O O   . HOH F 4 .   ? 67.432  81.102  136.287 1.00 31.01 ? 466 HOH L O   1 
HETATM 3457 O O   . HOH F 4 .   ? 53.646  58.553  117.651 1.00 42.92 ? 467 HOH L O   1 
HETATM 3458 O O   . HOH F 4 .   ? 86.869  105.615 124.511 1.00 28.43 ? 468 HOH L O   1 
HETATM 3459 O O   . HOH F 4 .   ? 80.226  82.076  131.151 1.00 35.38 ? 469 HOH L O   1 
HETATM 3460 O O   . HOH F 4 .   ? 64.887  63.121  130.898 1.00 16.72 ? 470 HOH L O   1 
HETATM 3461 O O   . HOH F 4 .   ? 60.720  75.083  122.584 1.00 26.25 ? 471 HOH L O   1 
HETATM 3462 O O   . HOH F 4 .   ? 70.122  71.868  141.235 1.00 32.58 ? 472 HOH L O   1 
HETATM 3463 O O   . HOH F 4 .   ? 95.251  85.311  137.323 1.00 38.10 ? 473 HOH L O   1 
HETATM 3464 O O   . HOH F 4 .   ? 85.684  101.468 140.434 1.00 46.67 ? 474 HOH L O   1 
HETATM 3465 O O   . HOH F 4 .   ? 69.959  58.092  132.613 1.00 32.07 ? 475 HOH L O   1 
HETATM 3466 O O   . HOH F 4 .   ? 83.242  75.660  143.089 1.00 34.94 ? 476 HOH L O   1 
HETATM 3467 O O   . HOH F 4 .   ? 88.648  98.914  142.665 1.00 47.91 ? 477 HOH L O   1 
HETATM 3468 O O   . HOH F 4 .   ? 78.080  86.859  148.683 1.00 49.25 ? 478 HOH L O   1 
HETATM 3469 O O   . HOH F 4 .   ? 81.089  97.373  124.333 1.00 34.75 ? 479 HOH L O   1 
HETATM 3470 O O   . HOH F 4 .   ? 67.661  66.536  118.696 1.00 28.40 ? 480 HOH L O   1 
HETATM 3471 O O   . HOH F 4 .   ? 75.913  65.662  119.647 1.00 29.64 ? 481 HOH L O   1 
HETATM 3472 O O   . HOH F 4 .   ? 60.545  61.186  110.807 1.00 46.83 ? 482 HOH L O   1 
HETATM 3473 O O   . HOH F 4 .   ? 54.371  61.271  116.692 1.00 33.29 ? 483 HOH L O   1 
HETATM 3474 O O   . HOH F 4 .   ? 76.699  55.198  132.391 1.00 51.41 ? 484 HOH L O   1 
HETATM 3475 O O   . HOH F 4 .   ? 61.451  78.860  132.992 1.00 35.35 ? 485 HOH L O   1 
HETATM 3476 O O   . HOH F 4 .   ? 88.812  94.934  138.794 1.00 39.36 ? 486 HOH L O   1 
HETATM 3477 O O   . HOH F 4 .   ? 91.173  90.396  136.048 1.00 35.18 ? 487 HOH L O   1 
HETATM 3478 O O   . HOH F 4 .   ? 87.255  105.866 135.564 1.00 32.21 ? 488 HOH L O   1 
HETATM 3479 O O   . HOH F 4 .   ? 68.614  78.828  122.993 1.00 25.33 ? 489 HOH L O   1 
HETATM 3480 O O   . HOH F 4 .   ? 70.758  54.871  132.665 1.00 39.07 ? 490 HOH L O   1 
HETATM 3481 O O   . HOH F 4 .   ? 86.478  68.260  134.625 1.00 30.64 ? 491 HOH L O   1 
HETATM 3482 O O   . HOH F 4 .   ? 87.113  84.877  130.338 1.00 34.15 ? 492 HOH L O   1 
HETATM 3483 O O   . HOH F 4 .   ? 71.019  94.542  141.085 1.00 38.70 ? 493 HOH L O   1 
HETATM 3484 O O   . HOH F 4 .   ? 74.498  83.739  134.469 1.00 37.67 ? 494 HOH L O   1 
HETATM 3485 O O   . HOH F 4 .   ? 75.227  113.117 133.105 1.00 31.69 ? 495 HOH L O   1 
HETATM 3486 O O   . HOH F 4 .   ? 69.849  101.521 125.800 1.00 47.41 ? 496 HOH L O   1 
HETATM 3487 O O   . HOH F 4 .   ? 89.111  91.878  141.130 1.00 45.05 ? 497 HOH L O   1 
HETATM 3488 O O   . HOH F 4 .   ? 59.285  51.994  115.851 1.00 38.20 ? 498 HOH L O   1 
HETATM 3489 O O   . HOH F 4 .   ? 75.225  101.874 119.424 1.00 32.10 ? 499 HOH L O   1 
HETATM 3490 O O   . HOH F 4 .   ? 54.059  69.140  116.557 1.00 36.99 ? 500 HOH L O   1 
HETATM 3491 O O   . HOH F 4 .   ? 70.504  79.930  129.216 1.00 38.29 ? 501 HOH L O   1 
HETATM 3492 O O   . HOH F 4 .   ? 74.265  94.908  120.811 1.00 36.25 ? 502 HOH L O   1 
HETATM 3493 O O   . HOH F 4 .   ? 83.618  80.753  121.565 1.00 33.42 ? 503 HOH L O   1 
HETATM 3494 O O   . HOH F 4 .   ? 56.205  80.881  123.193 1.00 51.68 ? 504 HOH L O   1 
HETATM 3495 O O   . HOH F 4 .   ? 78.535  78.420  128.754 1.00 34.93 ? 505 HOH L O   1 
HETATM 3496 O O   . HOH F 4 .   ? 82.538  65.577  144.950 1.00 44.18 ? 506 HOH L O   1 
HETATM 3497 O O   . HOH F 4 .   ? 72.301  96.766  124.336 1.00 44.91 ? 507 HOH L O   1 
HETATM 3498 O O   . HOH F 4 .   ? 77.333  78.491  123.989 1.00 37.34 ? 508 HOH L O   1 
HETATM 3499 O O   . HOH F 4 .   ? 80.001  64.801  129.133 1.00 45.80 ? 509 HOH L O   1 
HETATM 3500 O O   . HOH F 4 .   ? 65.554  81.244  127.431 1.00 34.64 ? 510 HOH L O   1 
HETATM 3501 O O   . HOH F 4 .   ? 90.816  83.552  142.472 1.00 46.37 ? 511 HOH L O   1 
HETATM 3502 O O   . HOH F 4 .   ? 66.177  61.403  140.305 1.00 43.42 ? 512 HOH L O   1 
HETATM 3503 O O   . HOH F 4 .   ? 79.077  63.885  146.960 1.00 43.00 ? 513 HOH L O   1 
HETATM 3504 O O   . HOH F 4 .   ? 59.636  64.733  140.216 1.00 46.77 ? 514 HOH L O   1 
HETATM 3505 O O   . HOH F 4 .   ? 56.655  64.342  139.582 1.00 55.15 ? 515 HOH L O   1 
# 
