data_8XS1
# 
_entry.id   8XS1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XS1         pdb_00008xs1 10.2210/pdb8xs1/pdb 
WWPDB D_1300044015 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-15 
2 'Structure model' 1 1 2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.pdbx_database_id_DOI'    
7  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8  2 'Structure model' '_citation.title'                   
9  2 'Structure model' '_citation.year'                    
10 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XS1 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'The same Fab antibody fragment only' 
_pdbx_database_related.db_id          5X5X 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rarai@shinshu-u.ac.jp 
_pdbx_contact_author.name_first         Ryoichi 
_pdbx_contact_author.name_last          Arai 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5606-8483 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Komatsu, M.' 1 ?                   
'Dong, J.'    2 0000-0002-7417-1932 
'Ueda, H.'    3 0000-0001-8849-4217 
'Arai, R.'    4 0000-0001-5606-8483 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? CH ? ? primary 'Int J Mol Sci'   ? ? 1422-0067 ? ? 26 ? ?    ?    
'Crystal Structures of Antigen-Binding Fragment of Anti-Osteocalcin Antibody KTM219.'                                          
2025 ? 10.3390/ijms26020648         39859361 ? ? 
? ? ? ? ? ? ? UK ? ? 1       'Sci Rep'         ? ? 2045-2322 ? ? 4  ? 4640 ?    
'Ultra Q-bodies: quench-based antibody probes that utilize dye-dye interactions with enhanced antigen-dependent fluorescence.' 
2014 ? 10.1038/srep04640            24721819 ? ? 
? ? ? ? ? ? ? CH ? ? 2       'Sensors (Basel)' ? ? 1424-8220 ? ? 21 ? ?    ?    
'Recent Advances in Quenchbody, a Fluorescent Immunosensor.'                                                                   
2021 ? 10.1016/j.cplett.2018.03.011 33572319 ? ? 
? ? ? ? ? ? ? US ? ? 3       'Anal Chem'       ? ? 0003-2700 ? ? 79 ? 6193 6200 
'Noncompetitive detection of low molecular weight peptides by open sandwich immunoassay.'                                      
2007 ? 10.1021/ac070653z            17636882 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yazaki, S.'   1  ?                   
primary 'Komatsu, M.'  2  ?                   
primary 'Dong, J.'     3  ?                   
primary 'Ueda, H.'     4  0000-0001-8849-4217 
primary 'Arai, R.'     5  0000-0001-5606-8483 
1       'Abe, R.'      6  ?                   
1       'Jeong, H.J.'  7  ?                   
1       'Arakawa, D.'  8  ?                   
1       'Dong, J.'     9  ?                   
1       'Ohashi, H.'   10 ?                   
1       'Kaigome, R.'  11 ?                   
1       'Saiki, F.'    12 ?                   
1       'Yamane, K.'   13 ?                   
1       'Takagi, H.'   14 ?                   
1       'Ueda, H.'     15 ?                   
2       'Dong, J.'     16 ?                   
2       'Ueda, H.'     17 0000-0001-8849-4217 
3       'Lim, S.L.'    18 ?                   
3       'Ichinose, H.' 19 ?                   
3       'Shinoda, T.'  20 ?                   
3       'Ueda, H.'     21 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Heavy chain fragment (Fd) chain of anti-osteocalcin antibody KTM219' 26202.979 1   ? ? ? ? 
2 polymer man 'Light chain of anti-osteocalcin antibody KTM219'                     25259.844 1   ? ? ? ? 
3 polymer syn Osteocalcin                                                           896.048   1   ? ? 
'C-terminal peptide (43-49) antigen' ? 
4 water   nat water                                                                 18.015    128 ? ? ? ? 
# 
_entity_name_com.entity_id   3 
_entity_name_com.name        'Bone Gla protein,BGP,Gamma-carboxyglutamic acid-containing protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MATGQVKLQQSGAEFVKAGASVKLSCKTSGYTFNNYWIHWVKQSPGQGLEWIGEIDPSDGYSNYNQKFKGKATLTVDKSS
STAYMHLNSLTSEDSAVYYCTSSTSVGGSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSASAAHHHHHHGAAEQKLI
SEEDLNGAA
;
;MATGQVKLQQSGAEFVKAGASVKLSCKTSGYTFNNYWIHWVKQSPGQGLEWIGEIDPSDGYSNYNQKFKGKATLTVDKSS
STAYMHLNSLTSEDSAVYYCTSSTSVGGSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSASAAHHHHHHGAAEQKLI
SEEDLNGAA
;
H ? 
2 'polypeptide(L)' no no 
;MSDIELTQSPLSLPVSLGDQASISCTSSQSLLHSNGDTYLHWYLQKPGQSPKLLIYTLSNRFSGVPDRFSGSGSGTDFTL
KISRVEAADLGIYFCSQTTHVPYTFGGGTKLEIKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA
LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEGGGSDYKDDDDK
;
;MSDIELTQSPLSLPVSLGDQASISCTSSQSLLHSNGDTYLHWYLQKPGQSPKLLIYTLSNRFSGVPDRFSGSGSGTDFTL
KISRVEAADLGIYFCSQTTHVPYTFGGGTKLEIKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA
LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEGGGSDYKDDDDK
;
L ? 
3 'polypeptide(L)' no no RRFYGPV RRFYGPV A ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   GLY n 
1 5   GLN n 
1 6   VAL n 
1 7   LYS n 
1 8   LEU n 
1 9   GLN n 
1 10  GLN n 
1 11  SER n 
1 12  GLY n 
1 13  ALA n 
1 14  GLU n 
1 15  PHE n 
1 16  VAL n 
1 17  LYS n 
1 18  ALA n 
1 19  GLY n 
1 20  ALA n 
1 21  SER n 
1 22  VAL n 
1 23  LYS n 
1 24  LEU n 
1 25  SER n 
1 26  CYS n 
1 27  LYS n 
1 28  THR n 
1 29  SER n 
1 30  GLY n 
1 31  TYR n 
1 32  THR n 
1 33  PHE n 
1 34  ASN n 
1 35  ASN n 
1 36  TYR n 
1 37  TRP n 
1 38  ILE n 
1 39  HIS n 
1 40  TRP n 
1 41  VAL n 
1 42  LYS n 
1 43  GLN n 
1 44  SER n 
1 45  PRO n 
1 46  GLY n 
1 47  GLN n 
1 48  GLY n 
1 49  LEU n 
1 50  GLU n 
1 51  TRP n 
1 52  ILE n 
1 53  GLY n 
1 54  GLU n 
1 55  ILE n 
1 56  ASP n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  GLY n 
1 61  TYR n 
1 62  SER n 
1 63  ASN n 
1 64  TYR n 
1 65  ASN n 
1 66  GLN n 
1 67  LYS n 
1 68  PHE n 
1 69  LYS n 
1 70  GLY n 
1 71  LYS n 
1 72  ALA n 
1 73  THR n 
1 74  LEU n 
1 75  THR n 
1 76  VAL n 
1 77  ASP n 
1 78  LYS n 
1 79  SER n 
1 80  SER n 
1 81  SER n 
1 82  THR n 
1 83  ALA n 
1 84  TYR n 
1 85  MET n 
1 86  HIS n 
1 87  LEU n 
1 88  ASN n 
1 89  SER n 
1 90  LEU n 
1 91  THR n 
1 92  SER n 
1 93  GLU n 
1 94  ASP n 
1 95  SER n 
1 96  ALA n 
1 97  VAL n 
1 98  TYR n 
1 99  TYR n 
1 100 CYS n 
1 101 THR n 
1 102 SER n 
1 103 SER n 
1 104 THR n 
1 105 SER n 
1 106 VAL n 
1 107 GLY n 
1 108 GLY n 
1 109 SER n 
1 110 TRP n 
1 111 GLY n 
1 112 GLN n 
1 113 GLY n 
1 114 THR n 
1 115 THR n 
1 116 VAL n 
1 117 THR n 
1 118 VAL n 
1 119 SER n 
1 120 SER n 
1 121 ALA n 
1 122 SER n 
1 123 THR n 
1 124 LYS n 
1 125 GLY n 
1 126 PRO n 
1 127 SER n 
1 128 VAL n 
1 129 PHE n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 PRO n 
1 134 SER n 
1 135 SER n 
1 136 LYS n 
1 137 SER n 
1 138 THR n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 ALA n 
1 144 ALA n 
1 145 LEU n 
1 146 GLY n 
1 147 CYS n 
1 148 LEU n 
1 149 VAL n 
1 150 LYS n 
1 151 ASP n 
1 152 TYR n 
1 153 PHE n 
1 154 PRO n 
1 155 GLU n 
1 156 PRO n 
1 157 VAL n 
1 158 THR n 
1 159 VAL n 
1 160 SER n 
1 161 TRP n 
1 162 ASN n 
1 163 SER n 
1 164 GLY n 
1 165 ALA n 
1 166 LEU n 
1 167 THR n 
1 168 SER n 
1 169 GLY n 
1 170 VAL n 
1 171 HIS n 
1 172 THR n 
1 173 PHE n 
1 174 PRO n 
1 175 ALA n 
1 176 VAL n 
1 177 LEU n 
1 178 GLN n 
1 179 SER n 
1 180 SER n 
1 181 GLY n 
1 182 LEU n 
1 183 TYR n 
1 184 SER n 
1 185 LEU n 
1 186 SER n 
1 187 SER n 
1 188 VAL n 
1 189 VAL n 
1 190 THR n 
1 191 VAL n 
1 192 PRO n 
1 193 SER n 
1 194 SER n 
1 195 SER n 
1 196 LEU n 
1 197 GLY n 
1 198 THR n 
1 199 GLN n 
1 200 THR n 
1 201 TYR n 
1 202 ILE n 
1 203 CYS n 
1 204 ASN n 
1 205 VAL n 
1 206 ASN n 
1 207 HIS n 
1 208 LYS n 
1 209 PRO n 
1 210 SER n 
1 211 ASN n 
1 212 THR n 
1 213 LYS n 
1 214 VAL n 
1 215 ASP n 
1 216 LYS n 
1 217 LYS n 
1 218 VAL n 
1 219 GLU n 
1 220 PRO n 
1 221 LYS n 
1 222 SER n 
1 223 ALA n 
1 224 SER n 
1 225 ALA n 
1 226 ALA n 
1 227 HIS n 
1 228 HIS n 
1 229 HIS n 
1 230 HIS n 
1 231 HIS n 
1 232 HIS n 
1 233 GLY n 
1 234 ALA n 
1 235 ALA n 
1 236 GLU n 
1 237 GLN n 
1 238 LYS n 
1 239 LEU n 
1 240 ILE n 
1 241 SER n 
1 242 GLU n 
1 243 GLU n 
1 244 ASP n 
1 245 LEU n 
1 246 ASN n 
1 247 GLY n 
1 248 ALA n 
1 249 ALA n 
2 1   MET n 
2 2   SER n 
2 3   ASP n 
2 4   ILE n 
2 5   GLU n 
2 6   LEU n 
2 7   THR n 
2 8   GLN n 
2 9   SER n 
2 10  PRO n 
2 11  LEU n 
2 12  SER n 
2 13  LEU n 
2 14  PRO n 
2 15  VAL n 
2 16  SER n 
2 17  LEU n 
2 18  GLY n 
2 19  ASP n 
2 20  GLN n 
2 21  ALA n 
2 22  SER n 
2 23  ILE n 
2 24  SER n 
2 25  CYS n 
2 26  THR n 
2 27  SER n 
2 28  SER n 
2 29  GLN n 
2 30  SER n 
2 31  LEU n 
2 32  LEU n 
2 33  HIS n 
2 34  SER n 
2 35  ASN n 
2 36  GLY n 
2 37  ASP n 
2 38  THR n 
2 39  TYR n 
2 40  LEU n 
2 41  HIS n 
2 42  TRP n 
2 43  TYR n 
2 44  LEU n 
2 45  GLN n 
2 46  LYS n 
2 47  PRO n 
2 48  GLY n 
2 49  GLN n 
2 50  SER n 
2 51  PRO n 
2 52  LYS n 
2 53  LEU n 
2 54  LEU n 
2 55  ILE n 
2 56  TYR n 
2 57  THR n 
2 58  LEU n 
2 59  SER n 
2 60  ASN n 
2 61  ARG n 
2 62  PHE n 
2 63  SER n 
2 64  GLY n 
2 65  VAL n 
2 66  PRO n 
2 67  ASP n 
2 68  ARG n 
2 69  PHE n 
2 70  SER n 
2 71  GLY n 
2 72  SER n 
2 73  GLY n 
2 74  SER n 
2 75  GLY n 
2 76  THR n 
2 77  ASP n 
2 78  PHE n 
2 79  THR n 
2 80  LEU n 
2 81  LYS n 
2 82  ILE n 
2 83  SER n 
2 84  ARG n 
2 85  VAL n 
2 86  GLU n 
2 87  ALA n 
2 88  ALA n 
2 89  ASP n 
2 90  LEU n 
2 91  GLY n 
2 92  ILE n 
2 93  TYR n 
2 94  PHE n 
2 95  CYS n 
2 96  SER n 
2 97  GLN n 
2 98  THR n 
2 99  THR n 
2 100 HIS n 
2 101 VAL n 
2 102 PRO n 
2 103 TYR n 
2 104 THR n 
2 105 PHE n 
2 106 GLY n 
2 107 GLY n 
2 108 GLY n 
2 109 THR n 
2 110 LYS n 
2 111 LEU n 
2 112 GLU n 
2 113 ILE n 
2 114 LYS n 
2 115 ARG n 
2 116 ALA n 
2 117 ASP n 
2 118 ALA n 
2 119 ALA n 
2 120 PRO n 
2 121 SER n 
2 122 VAL n 
2 123 PHE n 
2 124 ILE n 
2 125 PHE n 
2 126 PRO n 
2 127 PRO n 
2 128 SER n 
2 129 ASP n 
2 130 GLU n 
2 131 GLN n 
2 132 LEU n 
2 133 LYS n 
2 134 SER n 
2 135 GLY n 
2 136 THR n 
2 137 ALA n 
2 138 SER n 
2 139 VAL n 
2 140 VAL n 
2 141 CYS n 
2 142 LEU n 
2 143 LEU n 
2 144 ASN n 
2 145 ASN n 
2 146 PHE n 
2 147 TYR n 
2 148 PRO n 
2 149 ARG n 
2 150 GLU n 
2 151 ALA n 
2 152 LYS n 
2 153 VAL n 
2 154 GLN n 
2 155 TRP n 
2 156 LYS n 
2 157 VAL n 
2 158 ASP n 
2 159 ASN n 
2 160 ALA n 
2 161 LEU n 
2 162 GLN n 
2 163 SER n 
2 164 GLY n 
2 165 ASN n 
2 166 SER n 
2 167 GLN n 
2 168 GLU n 
2 169 SER n 
2 170 VAL n 
2 171 THR n 
2 172 GLU n 
2 173 GLN n 
2 174 ASP n 
2 175 SER n 
2 176 LYS n 
2 177 ASP n 
2 178 SER n 
2 179 THR n 
2 180 TYR n 
2 181 SER n 
2 182 LEU n 
2 183 SER n 
2 184 SER n 
2 185 THR n 
2 186 LEU n 
2 187 THR n 
2 188 LEU n 
2 189 SER n 
2 190 LYS n 
2 191 ALA n 
2 192 ASP n 
2 193 TYR n 
2 194 GLU n 
2 195 LYS n 
2 196 HIS n 
2 197 LYS n 
2 198 VAL n 
2 199 TYR n 
2 200 ALA n 
2 201 CYS n 
2 202 GLU n 
2 203 VAL n 
2 204 THR n 
2 205 HIS n 
2 206 GLN n 
2 207 GLY n 
2 208 LEU n 
2 209 SER n 
2 210 SER n 
2 211 PRO n 
2 212 VAL n 
2 213 THR n 
2 214 LYS n 
2 215 SER n 
2 216 PHE n 
2 217 ASN n 
2 218 ARG n 
2 219 GLY n 
2 220 GLU n 
2 221 GLY n 
2 222 GLY n 
2 223 GLY n 
2 224 SER n 
2 225 ASP n 
2 226 TYR n 
2 227 LYS n 
2 228 ASP n 
2 229 ASP n 
2 230 ASP n 
2 231 ASP n 
2 232 LYS n 
3 1   ARG n 
3 2   ARG n 
3 3   PHE n 
3 4   TYR n 
3 5   GLY n 
3 6   PRO n 
3 7   VAL n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 249 ? ? ? ? ? ? ? ? ? 'Mus musculus' 10090 ? 'HYBRIDOMA KTM-219' ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? 'SHuffle T7 Express lysY' ? ? ? ? ? ? ? PLASMID ? ? ? 'pET-Fab(KTM219)' ? ? 
2 1 sample 'Biological sequence' 1 232 ? ? ? ? ? ? ? ? ? 'Mus musculus' 10090 ? 'HYBRIDOMA KTM-219' ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? 'SHuffle T7 Express lysY' ? ? ? ? ? ? ? PLASMID ? ? ? 'pET-Fab(KTM219)' ? ? 
# 
_pdbx_entity_src_syn.entity_id              3 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       7 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   H . n 
A 1 2   ALA 2   -2  ?   ?   ?   H . n 
A 1 3   THR 3   -1  ?   ?   ?   H . n 
A 1 4   GLY 4   0   ?   ?   ?   H . n 
A 1 5   GLN 5   1   ?   ?   ?   H . n 
A 1 6   VAL 6   2   ?   ?   ?   H . n 
A 1 7   LYS 7   3   3   LYS LYS H . n 
A 1 8   LEU 8   4   4   LEU LEU H . n 
A 1 9   GLN 9   5   5   GLN GLN H . n 
A 1 10  GLN 10  6   6   GLN GLN H . n 
A 1 11  SER 11  7   7   SER SER H . n 
A 1 12  GLY 12  8   8   GLY GLY H . n 
A 1 13  ALA 13  9   9   ALA ALA H . n 
A 1 14  GLU 14  10  10  GLU GLU H . n 
A 1 15  PHE 15  11  11  PHE PHE H . n 
A 1 16  VAL 16  12  12  VAL VAL H . n 
A 1 17  LYS 17  13  13  LYS LYS H . n 
A 1 18  ALA 18  14  14  ALA ALA H . n 
A 1 19  GLY 19  15  15  GLY GLY H . n 
A 1 20  ALA 20  16  16  ALA ALA H . n 
A 1 21  SER 21  17  17  SER SER H . n 
A 1 22  VAL 22  18  18  VAL VAL H . n 
A 1 23  LYS 23  19  19  LYS LYS H . n 
A 1 24  LEU 24  20  20  LEU LEU H . n 
A 1 25  SER 25  21  21  SER SER H . n 
A 1 26  CYS 26  22  22  CYS CYS H . n 
A 1 27  LYS 27  23  23  LYS LYS H . n 
A 1 28  THR 28  24  24  THR THR H . n 
A 1 29  SER 29  25  25  SER SER H . n 
A 1 30  GLY 30  26  26  GLY GLY H . n 
A 1 31  TYR 31  27  27  TYR TYR H . n 
A 1 32  THR 32  28  28  THR THR H . n 
A 1 33  PHE 33  29  29  PHE PHE H . n 
A 1 34  ASN 34  30  30  ASN ASN H . n 
A 1 35  ASN 35  31  31  ASN ASN H . n 
A 1 36  TYR 36  32  32  TYR TYR H . n 
A 1 37  TRP 37  33  33  TRP TRP H . n 
A 1 38  ILE 38  34  34  ILE ILE H . n 
A 1 39  HIS 39  35  35  HIS HIS H . n 
A 1 40  TRP 40  36  36  TRP TRP H . n 
A 1 41  VAL 41  37  37  VAL VAL H . n 
A 1 42  LYS 42  38  38  LYS LYS H . n 
A 1 43  GLN 43  39  39  GLN GLN H . n 
A 1 44  SER 44  40  40  SER SER H . n 
A 1 45  PRO 45  41  41  PRO PRO H . n 
A 1 46  GLY 46  42  42  GLY GLY H . n 
A 1 47  GLN 47  43  43  GLN GLN H . n 
A 1 48  GLY 48  44  44  GLY GLY H . n 
A 1 49  LEU 49  45  45  LEU LEU H . n 
A 1 50  GLU 50  46  46  GLU GLU H . n 
A 1 51  TRP 51  47  47  TRP TRP H . n 
A 1 52  ILE 52  48  48  ILE ILE H . n 
A 1 53  GLY 53  49  49  GLY GLY H . n 
A 1 54  GLU 54  50  50  GLU GLU H . n 
A 1 55  ILE 55  51  51  ILE ILE H . n 
A 1 56  ASP 56  52  52  ASP ASP H . n 
A 1 57  PRO 57  52  52  PRO PRO H A n 
A 1 58  SER 58  53  53  SER SER H . n 
A 1 59  ASP 59  54  54  ASP ASP H . n 
A 1 60  GLY 60  55  55  GLY GLY H . n 
A 1 61  TYR 61  56  56  TYR TYR H . n 
A 1 62  SER 62  57  57  SER SER H . n 
A 1 63  ASN 63  58  58  ASN ASN H . n 
A 1 64  TYR 64  59  59  TYR TYR H . n 
A 1 65  ASN 65  60  60  ASN ASN H . n 
A 1 66  GLN 66  61  61  GLN GLN H . n 
A 1 67  LYS 67  62  62  LYS LYS H . n 
A 1 68  PHE 68  63  63  PHE PHE H . n 
A 1 69  LYS 69  64  64  LYS LYS H . n 
A 1 70  GLY 70  65  65  GLY GLY H . n 
A 1 71  LYS 71  66  66  LYS LYS H . n 
A 1 72  ALA 72  67  67  ALA ALA H . n 
A 1 73  THR 73  68  68  THR THR H . n 
A 1 74  LEU 74  69  69  LEU LEU H . n 
A 1 75  THR 75  70  70  THR THR H . n 
A 1 76  VAL 76  71  71  VAL VAL H . n 
A 1 77  ASP 77  72  72  ASP ASP H . n 
A 1 78  LYS 78  73  73  LYS LYS H . n 
A 1 79  SER 79  74  74  SER SER H . n 
A 1 80  SER 80  75  75  SER SER H . n 
A 1 81  SER 81  76  76  SER SER H . n 
A 1 82  THR 82  77  77  THR THR H . n 
A 1 83  ALA 83  78  78  ALA ALA H . n 
A 1 84  TYR 84  79  79  TYR TYR H . n 
A 1 85  MET 85  80  80  MET MET H . n 
A 1 86  HIS 86  81  81  HIS HIS H . n 
A 1 87  LEU 87  82  82  LEU LEU H . n 
A 1 88  ASN 88  82  82  ASN ASN H A n 
A 1 89  SER 89  82  82  SER SER H B n 
A 1 90  LEU 90  82  82  LEU LEU H C n 
A 1 91  THR 91  83  83  THR THR H . n 
A 1 92  SER 92  84  84  SER SER H . n 
A 1 93  GLU 93  85  85  GLU GLU H . n 
A 1 94  ASP 94  86  86  ASP ASP H . n 
A 1 95  SER 95  87  87  SER SER H . n 
A 1 96  ALA 96  88  88  ALA ALA H . n 
A 1 97  VAL 97  89  89  VAL VAL H . n 
A 1 98  TYR 98  90  90  TYR TYR H . n 
A 1 99  TYR 99  91  91  TYR TYR H . n 
A 1 100 CYS 100 92  92  CYS CYS H . n 
A 1 101 THR 101 93  93  THR THR H . n 
A 1 102 SER 102 94  94  SER SER H . n 
A 1 103 SER 103 95  95  SER SER H . n 
A 1 104 THR 104 96  96  THR THR H . n 
A 1 105 SER 105 97  97  SER SER H . n 
A 1 106 VAL 106 98  98  VAL VAL H . n 
A 1 107 GLY 107 99  99  GLY GLY H . n 
A 1 108 GLY 108 101 101 GLY GLY H . n 
A 1 109 SER 109 102 102 SER SER H . n 
A 1 110 TRP 110 103 103 TRP TRP H . n 
A 1 111 GLY 111 104 104 GLY GLY H . n 
A 1 112 GLN 112 105 105 GLN GLN H . n 
A 1 113 GLY 113 106 106 GLY GLY H . n 
A 1 114 THR 114 107 107 THR THR H . n 
A 1 115 THR 115 108 108 THR THR H . n 
A 1 116 VAL 116 109 109 VAL VAL H . n 
A 1 117 THR 117 110 110 THR THR H . n 
A 1 118 VAL 118 111 111 VAL VAL H . n 
A 1 119 SER 119 112 112 SER SER H . n 
A 1 120 SER 120 113 113 SER SER H . n 
A 1 121 ALA 121 114 114 ALA ALA H . n 
A 1 122 SER 122 115 115 SER SER H . n 
A 1 123 THR 123 116 116 THR THR H . n 
A 1 124 LYS 124 117 117 LYS LYS H . n 
A 1 125 GLY 125 118 118 GLY GLY H . n 
A 1 126 PRO 126 119 119 PRO PRO H . n 
A 1 127 SER 127 120 120 SER SER H . n 
A 1 128 VAL 128 121 121 VAL VAL H . n 
A 1 129 PHE 129 122 122 PHE PHE H . n 
A 1 130 PRO 130 123 123 PRO PRO H . n 
A 1 131 LEU 131 124 124 LEU LEU H . n 
A 1 132 ALA 132 125 125 ALA ALA H . n 
A 1 133 PRO 133 126 126 PRO PRO H . n 
A 1 134 SER 134 127 127 SER SER H . n 
A 1 135 SER 135 128 128 SER SER H . n 
A 1 136 LYS 136 129 129 LYS LYS H . n 
A 1 137 SER 137 130 130 SER SER H . n 
A 1 138 THR 138 131 131 THR THR H . n 
A 1 139 SER 139 132 132 SER SER H . n 
A 1 140 GLY 140 133 133 GLY GLY H . n 
A 1 141 GLY 141 134 134 GLY GLY H . n 
A 1 142 THR 142 135 135 THR THR H . n 
A 1 143 ALA 143 136 136 ALA ALA H . n 
A 1 144 ALA 144 137 137 ALA ALA H . n 
A 1 145 LEU 145 138 138 LEU LEU H . n 
A 1 146 GLY 146 139 139 GLY GLY H . n 
A 1 147 CYS 147 140 140 CYS CYS H . n 
A 1 148 LEU 148 141 141 LEU LEU H . n 
A 1 149 VAL 149 142 142 VAL VAL H . n 
A 1 150 LYS 150 143 143 LYS LYS H . n 
A 1 151 ASP 151 144 144 ASP ASP H . n 
A 1 152 TYR 152 145 145 TYR TYR H . n 
A 1 153 PHE 153 146 146 PHE PHE H . n 
A 1 154 PRO 154 147 147 PRO PRO H . n 
A 1 155 GLU 155 148 148 GLU GLU H . n 
A 1 156 PRO 156 149 149 PRO PRO H . n 
A 1 157 VAL 157 150 150 VAL VAL H . n 
A 1 158 THR 158 151 151 THR THR H . n 
A 1 159 VAL 159 152 152 VAL VAL H . n 
A 1 160 SER 160 153 153 SER SER H . n 
A 1 161 TRP 161 154 154 TRP TRP H . n 
A 1 162 ASN 162 155 155 ASN ASN H . n 
A 1 163 SER 163 156 156 SER SER H . n 
A 1 164 GLY 164 157 157 GLY GLY H . n 
A 1 165 ALA 165 158 158 ALA ALA H . n 
A 1 166 LEU 166 159 159 LEU LEU H . n 
A 1 167 THR 167 160 160 THR THR H . n 
A 1 168 SER 168 161 161 SER SER H . n 
A 1 169 GLY 169 162 162 GLY GLY H . n 
A 1 170 VAL 170 163 163 VAL VAL H . n 
A 1 171 HIS 171 164 164 HIS HIS H . n 
A 1 172 THR 172 165 165 THR THR H . n 
A 1 173 PHE 173 166 166 PHE PHE H . n 
A 1 174 PRO 174 167 167 PRO PRO H . n 
A 1 175 ALA 175 168 168 ALA ALA H . n 
A 1 176 VAL 176 169 169 VAL VAL H . n 
A 1 177 LEU 177 170 170 LEU LEU H . n 
A 1 178 GLN 178 171 171 GLN GLN H . n 
A 1 179 SER 179 172 172 SER SER H . n 
A 1 180 SER 180 173 173 SER SER H . n 
A 1 181 GLY 181 174 174 GLY GLY H . n 
A 1 182 LEU 182 175 175 LEU LEU H . n 
A 1 183 TYR 183 176 176 TYR TYR H . n 
A 1 184 SER 184 177 177 SER SER H . n 
A 1 185 LEU 185 178 178 LEU LEU H . n 
A 1 186 SER 186 179 179 SER SER H . n 
A 1 187 SER 187 180 180 SER SER H . n 
A 1 188 VAL 188 181 181 VAL VAL H . n 
A 1 189 VAL 189 182 182 VAL VAL H . n 
A 1 190 THR 190 183 183 THR THR H . n 
A 1 191 VAL 191 184 184 VAL VAL H . n 
A 1 192 PRO 192 185 185 PRO PRO H . n 
A 1 193 SER 193 186 186 SER SER H . n 
A 1 194 SER 194 187 187 SER SER H . n 
A 1 195 SER 195 188 188 SER SER H . n 
A 1 196 LEU 196 189 189 LEU LEU H . n 
A 1 197 GLY 197 190 190 GLY GLY H . n 
A 1 198 THR 198 191 191 THR THR H . n 
A 1 199 GLN 199 192 192 GLN GLN H . n 
A 1 200 THR 200 193 193 THR THR H . n 
A 1 201 TYR 201 194 194 TYR TYR H . n 
A 1 202 ILE 202 195 195 ILE ILE H . n 
A 1 203 CYS 203 196 196 CYS CYS H . n 
A 1 204 ASN 204 197 197 ASN ASN H . n 
A 1 205 VAL 205 198 198 VAL VAL H . n 
A 1 206 ASN 206 199 199 ASN ASN H . n 
A 1 207 HIS 207 200 200 HIS HIS H . n 
A 1 208 LYS 208 201 201 LYS LYS H . n 
A 1 209 PRO 209 202 202 PRO PRO H . n 
A 1 210 SER 210 203 203 SER SER H . n 
A 1 211 ASN 211 204 204 ASN ASN H . n 
A 1 212 THR 212 205 205 THR THR H . n 
A 1 213 LYS 213 206 206 LYS LYS H . n 
A 1 214 VAL 214 207 207 VAL VAL H . n 
A 1 215 ASP 215 208 208 ASP ASP H . n 
A 1 216 LYS 216 209 209 LYS LYS H . n 
A 1 217 LYS 217 210 210 LYS LYS H . n 
A 1 218 VAL 218 211 211 VAL VAL H . n 
A 1 219 GLU 219 212 212 GLU GLU H . n 
A 1 220 PRO 220 213 213 PRO PRO H . n 
A 1 221 LYS 221 214 ?   ?   ?   H . n 
A 1 222 SER 222 215 ?   ?   ?   H . n 
A 1 223 ALA 223 216 ?   ?   ?   H . n 
A 1 224 SER 224 217 ?   ?   ?   H . n 
A 1 225 ALA 225 218 ?   ?   ?   H . n 
A 1 226 ALA 226 219 ?   ?   ?   H . n 
A 1 227 HIS 227 220 ?   ?   ?   H . n 
A 1 228 HIS 228 221 ?   ?   ?   H . n 
A 1 229 HIS 229 222 ?   ?   ?   H . n 
A 1 230 HIS 230 223 ?   ?   ?   H . n 
A 1 231 HIS 231 224 ?   ?   ?   H . n 
A 1 232 HIS 232 225 ?   ?   ?   H . n 
A 1 233 GLY 233 226 ?   ?   ?   H . n 
A 1 234 ALA 234 227 ?   ?   ?   H . n 
A 1 235 ALA 235 228 ?   ?   ?   H . n 
A 1 236 GLU 236 229 ?   ?   ?   H . n 
A 1 237 GLN 237 230 ?   ?   ?   H . n 
A 1 238 LYS 238 231 ?   ?   ?   H . n 
A 1 239 LEU 239 232 ?   ?   ?   H . n 
A 1 240 ILE 240 233 ?   ?   ?   H . n 
A 1 241 SER 241 234 ?   ?   ?   H . n 
A 1 242 GLU 242 235 ?   ?   ?   H . n 
A 1 243 GLU 243 236 ?   ?   ?   H . n 
A 1 244 ASP 244 237 ?   ?   ?   H . n 
A 1 245 LEU 245 238 ?   ?   ?   H . n 
A 1 246 ASN 246 239 ?   ?   ?   H . n 
A 1 247 GLY 247 240 ?   ?   ?   H . n 
A 1 248 ALA 248 241 ?   ?   ?   H . n 
A 1 249 ALA 249 242 ?   ?   ?   H . n 
B 2 1   MET 1   -1  ?   ?   ?   L . n 
B 2 2   SER 2   0   0   SER SER L . n 
B 2 3   ASP 3   1   1   ASP ASP L . n 
B 2 4   ILE 4   2   2   ILE ILE L . n 
B 2 5   GLU 5   3   3   GLU GLU L . n 
B 2 6   LEU 6   4   4   LEU LEU L . n 
B 2 7   THR 7   5   5   THR THR L . n 
B 2 8   GLN 8   6   6   GLN GLN L . n 
B 2 9   SER 9   7   7   SER SER L . n 
B 2 10  PRO 10  8   8   PRO PRO L . n 
B 2 11  LEU 11  9   9   LEU LEU L . n 
B 2 12  SER 12  10  10  SER SER L . n 
B 2 13  LEU 13  11  11  LEU LEU L . n 
B 2 14  PRO 14  12  12  PRO PRO L . n 
B 2 15  VAL 15  13  13  VAL VAL L . n 
B 2 16  SER 16  14  14  SER SER L . n 
B 2 17  LEU 17  15  15  LEU LEU L . n 
B 2 18  GLY 18  16  16  GLY GLY L . n 
B 2 19  ASP 19  17  17  ASP ASP L . n 
B 2 20  GLN 20  18  18  GLN GLN L . n 
B 2 21  ALA 21  19  19  ALA ALA L . n 
B 2 22  SER 22  20  20  SER SER L . n 
B 2 23  ILE 23  21  21  ILE ILE L . n 
B 2 24  SER 24  22  22  SER SER L . n 
B 2 25  CYS 25  23  23  CYS CYS L . n 
B 2 26  THR 26  24  24  THR THR L . n 
B 2 27  SER 27  25  25  SER SER L . n 
B 2 28  SER 28  26  26  SER SER L . n 
B 2 29  GLN 29  27  27  GLN GLN L . n 
B 2 30  SER 30  27  27  SER SER L A n 
B 2 31  LEU 31  27  27  LEU LEU L B n 
B 2 32  LEU 32  27  27  LEU LEU L C n 
B 2 33  HIS 33  27  27  HIS HIS L D n 
B 2 34  SER 34  27  27  SER SER L E n 
B 2 35  ASN 35  28  28  ASN ASN L . n 
B 2 36  GLY 36  29  29  GLY GLY L . n 
B 2 37  ASP 37  30  30  ASP ASP L . n 
B 2 38  THR 38  31  31  THR THR L . n 
B 2 39  TYR 39  32  32  TYR TYR L . n 
B 2 40  LEU 40  33  33  LEU LEU L . n 
B 2 41  HIS 41  34  34  HIS HIS L . n 
B 2 42  TRP 42  35  35  TRP TRP L . n 
B 2 43  TYR 43  36  36  TYR TYR L . n 
B 2 44  LEU 44  37  37  LEU LEU L . n 
B 2 45  GLN 45  38  38  GLN GLN L . n 
B 2 46  LYS 46  39  39  LYS LYS L . n 
B 2 47  PRO 47  40  40  PRO PRO L . n 
B 2 48  GLY 48  41  41  GLY GLY L . n 
B 2 49  GLN 49  42  42  GLN GLN L . n 
B 2 50  SER 50  43  43  SER SER L . n 
B 2 51  PRO 51  44  44  PRO PRO L . n 
B 2 52  LYS 52  45  45  LYS LYS L . n 
B 2 53  LEU 53  46  46  LEU LEU L . n 
B 2 54  LEU 54  47  47  LEU LEU L . n 
B 2 55  ILE 55  48  48  ILE ILE L . n 
B 2 56  TYR 56  49  49  TYR TYR L . n 
B 2 57  THR 57  50  50  THR THR L . n 
B 2 58  LEU 58  51  51  LEU LEU L . n 
B 2 59  SER 59  52  52  SER SER L . n 
B 2 60  ASN 60  53  53  ASN ASN L . n 
B 2 61  ARG 61  54  54  ARG ARG L . n 
B 2 62  PHE 62  55  55  PHE PHE L . n 
B 2 63  SER 63  56  56  SER SER L . n 
B 2 64  GLY 64  57  57  GLY GLY L . n 
B 2 65  VAL 65  58  58  VAL VAL L . n 
B 2 66  PRO 66  59  59  PRO PRO L . n 
B 2 67  ASP 67  60  60  ASP ASP L . n 
B 2 68  ARG 68  61  61  ARG ARG L . n 
B 2 69  PHE 69  62  62  PHE PHE L . n 
B 2 70  SER 70  63  63  SER SER L . n 
B 2 71  GLY 71  64  64  GLY GLY L . n 
B 2 72  SER 72  65  65  SER SER L . n 
B 2 73  GLY 73  66  66  GLY GLY L . n 
B 2 74  SER 74  67  67  SER SER L . n 
B 2 75  GLY 75  68  68  GLY GLY L . n 
B 2 76  THR 76  69  69  THR THR L . n 
B 2 77  ASP 77  70  70  ASP ASP L . n 
B 2 78  PHE 78  71  71  PHE PHE L . n 
B 2 79  THR 79  72  72  THR THR L . n 
B 2 80  LEU 80  73  73  LEU LEU L . n 
B 2 81  LYS 81  74  74  LYS LYS L . n 
B 2 82  ILE 82  75  75  ILE ILE L . n 
B 2 83  SER 83  76  76  SER SER L . n 
B 2 84  ARG 84  77  77  ARG ARG L . n 
B 2 85  VAL 85  78  78  VAL VAL L . n 
B 2 86  GLU 86  79  79  GLU GLU L . n 
B 2 87  ALA 87  80  80  ALA ALA L . n 
B 2 88  ALA 88  81  81  ALA ALA L . n 
B 2 89  ASP 89  82  82  ASP ASP L . n 
B 2 90  LEU 90  83  83  LEU LEU L . n 
B 2 91  GLY 91  84  84  GLY GLY L . n 
B 2 92  ILE 92  85  85  ILE ILE L . n 
B 2 93  TYR 93  86  86  TYR TYR L . n 
B 2 94  PHE 94  87  87  PHE PHE L . n 
B 2 95  CYS 95  88  88  CYS CYS L . n 
B 2 96  SER 96  89  89  SER SER L . n 
B 2 97  GLN 97  90  90  GLN GLN L . n 
B 2 98  THR 98  91  91  THR THR L . n 
B 2 99  THR 99  92  92  THR THR L . n 
B 2 100 HIS 100 93  93  HIS HIS L . n 
B 2 101 VAL 101 94  94  VAL VAL L . n 
B 2 102 PRO 102 95  95  PRO PRO L . n 
B 2 103 TYR 103 96  96  TYR TYR L . n 
B 2 104 THR 104 97  97  THR THR L . n 
B 2 105 PHE 105 98  98  PHE PHE L . n 
B 2 106 GLY 106 99  99  GLY GLY L . n 
B 2 107 GLY 107 100 100 GLY GLY L . n 
B 2 108 GLY 108 101 101 GLY GLY L . n 
B 2 109 THR 109 102 102 THR THR L . n 
B 2 110 LYS 110 103 103 LYS LYS L . n 
B 2 111 LEU 111 104 104 LEU LEU L . n 
B 2 112 GLU 112 105 105 GLU GLU L . n 
B 2 113 ILE 113 106 106 ILE ILE L . n 
B 2 114 LYS 114 107 107 LYS LYS L . n 
B 2 115 ARG 115 108 108 ARG ARG L . n 
B 2 116 ALA 116 109 109 ALA ALA L . n 
B 2 117 ASP 117 110 110 ASP ASP L . n 
B 2 118 ALA 118 111 111 ALA ALA L . n 
B 2 119 ALA 119 112 112 ALA ALA L . n 
B 2 120 PRO 120 113 113 PRO PRO L . n 
B 2 121 SER 121 114 114 SER SER L . n 
B 2 122 VAL 122 115 115 VAL VAL L . n 
B 2 123 PHE 123 116 116 PHE PHE L . n 
B 2 124 ILE 124 117 117 ILE ILE L . n 
B 2 125 PHE 125 118 118 PHE PHE L . n 
B 2 126 PRO 126 119 119 PRO PRO L . n 
B 2 127 PRO 127 120 120 PRO PRO L . n 
B 2 128 SER 128 121 121 SER SER L . n 
B 2 129 ASP 129 122 122 ASP ASP L . n 
B 2 130 GLU 130 123 123 GLU GLU L . n 
B 2 131 GLN 131 124 124 GLN GLN L . n 
B 2 132 LEU 132 125 125 LEU LEU L . n 
B 2 133 LYS 133 126 126 LYS LYS L . n 
B 2 134 SER 134 127 127 SER SER L . n 
B 2 135 GLY 135 128 128 GLY GLY L . n 
B 2 136 THR 136 129 129 THR THR L . n 
B 2 137 ALA 137 130 130 ALA ALA L . n 
B 2 138 SER 138 131 131 SER SER L . n 
B 2 139 VAL 139 132 132 VAL VAL L . n 
B 2 140 VAL 140 133 133 VAL VAL L . n 
B 2 141 CYS 141 134 134 CYS CYS L . n 
B 2 142 LEU 142 135 135 LEU LEU L . n 
B 2 143 LEU 143 136 136 LEU LEU L . n 
B 2 144 ASN 144 137 137 ASN ASN L . n 
B 2 145 ASN 145 138 138 ASN ASN L . n 
B 2 146 PHE 146 139 139 PHE PHE L . n 
B 2 147 TYR 147 140 140 TYR TYR L . n 
B 2 148 PRO 148 141 141 PRO PRO L . n 
B 2 149 ARG 149 142 142 ARG ARG L . n 
B 2 150 GLU 150 143 143 GLU GLU L . n 
B 2 151 ALA 151 144 144 ALA ALA L . n 
B 2 152 LYS 152 145 145 LYS LYS L . n 
B 2 153 VAL 153 146 146 VAL VAL L . n 
B 2 154 GLN 154 147 147 GLN GLN L . n 
B 2 155 TRP 155 148 148 TRP TRP L . n 
B 2 156 LYS 156 149 149 LYS LYS L . n 
B 2 157 VAL 157 150 150 VAL VAL L . n 
B 2 158 ASP 158 151 151 ASP ASP L . n 
B 2 159 ASN 159 152 152 ASN ASN L . n 
B 2 160 ALA 160 153 153 ALA ALA L . n 
B 2 161 LEU 161 154 154 LEU LEU L . n 
B 2 162 GLN 162 155 155 GLN GLN L . n 
B 2 163 SER 163 156 156 SER SER L . n 
B 2 164 GLY 164 157 157 GLY GLY L . n 
B 2 165 ASN 165 158 158 ASN ASN L . n 
B 2 166 SER 166 159 159 SER SER L . n 
B 2 167 GLN 167 160 160 GLN GLN L . n 
B 2 168 GLU 168 161 161 GLU GLU L . n 
B 2 169 SER 169 162 162 SER SER L . n 
B 2 170 VAL 170 163 163 VAL VAL L . n 
B 2 171 THR 171 164 164 THR THR L . n 
B 2 172 GLU 172 165 165 GLU GLU L . n 
B 2 173 GLN 173 166 166 GLN GLN L . n 
B 2 174 ASP 174 167 167 ASP ASP L . n 
B 2 175 SER 175 168 168 SER SER L . n 
B 2 176 LYS 176 169 169 LYS LYS L . n 
B 2 177 ASP 177 170 170 ASP ASP L . n 
B 2 178 SER 178 171 171 SER SER L . n 
B 2 179 THR 179 172 172 THR THR L . n 
B 2 180 TYR 180 173 173 TYR TYR L . n 
B 2 181 SER 181 174 174 SER SER L . n 
B 2 182 LEU 182 175 175 LEU LEU L . n 
B 2 183 SER 183 176 176 SER SER L . n 
B 2 184 SER 184 177 177 SER SER L . n 
B 2 185 THR 185 178 178 THR THR L . n 
B 2 186 LEU 186 179 179 LEU LEU L . n 
B 2 187 THR 187 180 180 THR THR L . n 
B 2 188 LEU 188 181 181 LEU LEU L . n 
B 2 189 SER 189 182 182 SER SER L . n 
B 2 190 LYS 190 183 183 LYS LYS L . n 
B 2 191 ALA 191 184 184 ALA ALA L . n 
B 2 192 ASP 192 185 185 ASP ASP L . n 
B 2 193 TYR 193 186 186 TYR TYR L . n 
B 2 194 GLU 194 187 187 GLU GLU L . n 
B 2 195 LYS 195 188 188 LYS LYS L . n 
B 2 196 HIS 196 189 189 HIS HIS L . n 
B 2 197 LYS 197 190 190 LYS LYS L . n 
B 2 198 VAL 198 191 191 VAL VAL L . n 
B 2 199 TYR 199 192 192 TYR TYR L . n 
B 2 200 ALA 200 193 193 ALA ALA L . n 
B 2 201 CYS 201 194 194 CYS CYS L . n 
B 2 202 GLU 202 195 195 GLU GLU L . n 
B 2 203 VAL 203 196 196 VAL VAL L . n 
B 2 204 THR 204 197 197 THR THR L . n 
B 2 205 HIS 205 198 198 HIS HIS L . n 
B 2 206 GLN 206 199 199 GLN GLN L . n 
B 2 207 GLY 207 200 200 GLY GLY L . n 
B 2 208 LEU 208 201 201 LEU LEU L . n 
B 2 209 SER 209 202 202 SER SER L . n 
B 2 210 SER 210 203 203 SER SER L . n 
B 2 211 PRO 211 204 204 PRO PRO L . n 
B 2 212 VAL 212 205 205 VAL VAL L . n 
B 2 213 THR 213 206 206 THR THR L . n 
B 2 214 LYS 214 207 207 LYS LYS L . n 
B 2 215 SER 215 208 208 SER SER L . n 
B 2 216 PHE 216 209 209 PHE PHE L . n 
B 2 217 ASN 217 210 210 ASN ASN L . n 
B 2 218 ARG 218 211 211 ARG ARG L . n 
B 2 219 GLY 219 212 ?   ?   ?   L . n 
B 2 220 GLU 220 213 ?   ?   ?   L . n 
B 2 221 GLY 221 214 ?   ?   ?   L . n 
B 2 222 GLY 222 215 ?   ?   ?   L . n 
B 2 223 GLY 223 216 ?   ?   ?   L . n 
B 2 224 SER 224 217 ?   ?   ?   L . n 
B 2 225 ASP 225 218 ?   ?   ?   L . n 
B 2 226 TYR 226 219 ?   ?   ?   L . n 
B 2 227 LYS 227 220 ?   ?   ?   L . n 
B 2 228 ASP 228 221 ?   ?   ?   L . n 
B 2 229 ASP 229 222 ?   ?   ?   L . n 
B 2 230 ASP 230 223 ?   ?   ?   L . n 
B 2 231 ASP 231 224 ?   ?   ?   L . n 
B 2 232 LYS 232 225 ?   ?   ?   L . n 
C 3 1   ARG 1   43  43  ARG ARG A . n 
C 3 2   ARG 2   44  44  ARG ARG A . n 
C 3 3   PHE 3   45  45  PHE PHE A . n 
C 3 4   TYR 4   46  46  TYR TYR A . n 
C 3 5   GLY 5   47  47  GLY GLY A . n 
C 3 6   PRO 6   48  48  PRO PRO A . n 
C 3 7   VAL 7   49  49  VAL VAL A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1  301 301 HOH HOH H . 
D 4 HOH 2  302 302 HOH HOH H . 
D 4 HOH 3  303 303 HOH HOH H . 
D 4 HOH 4  304 304 HOH HOH H . 
D 4 HOH 5  305 305 HOH HOH H . 
D 4 HOH 6  306 308 HOH HOH H . 
D 4 HOH 7  307 306 HOH HOH H . 
D 4 HOH 8  308 307 HOH HOH H . 
D 4 HOH 9  309 309 HOH HOH H . 
D 4 HOH 10 310 310 HOH HOH H . 
D 4 HOH 11 311 311 HOH HOH H . 
D 4 HOH 12 312 312 HOH HOH H . 
D 4 HOH 13 313 313 HOH HOH H . 
D 4 HOH 14 314 314 HOH HOH H . 
D 4 HOH 15 315 315 HOH HOH H . 
D 4 HOH 16 316 317 HOH HOH H . 
D 4 HOH 17 317 316 HOH HOH H . 
D 4 HOH 18 318 318 HOH HOH H . 
D 4 HOH 19 319 319 HOH HOH H . 
D 4 HOH 20 320 320 HOH HOH H . 
D 4 HOH 21 321 321 HOH HOH H . 
D 4 HOH 22 322 322 HOH HOH H . 
D 4 HOH 23 323 323 HOH HOH H . 
D 4 HOH 24 324 324 HOH HOH H . 
D 4 HOH 25 325 325 HOH HOH H . 
D 4 HOH 26 326 326 HOH HOH H . 
D 4 HOH 27 327 327 HOH HOH H . 
D 4 HOH 28 328 328 HOH HOH H . 
D 4 HOH 29 329 329 HOH HOH H . 
D 4 HOH 30 330 330 HOH HOH H . 
D 4 HOH 31 331 332 HOH HOH H . 
D 4 HOH 32 332 331 HOH HOH H . 
D 4 HOH 33 333 333 HOH HOH H . 
D 4 HOH 34 334 334 HOH HOH H . 
D 4 HOH 35 335 335 HOH HOH H . 
D 4 HOH 36 336 336 HOH HOH H . 
D 4 HOH 37 337 337 HOH HOH H . 
D 4 HOH 38 338 339 HOH HOH H . 
D 4 HOH 39 339 338 HOH HOH H . 
D 4 HOH 40 340 340 HOH HOH H . 
D 4 HOH 41 341 341 HOH HOH H . 
D 4 HOH 42 342 342 HOH HOH H . 
D 4 HOH 43 343 343 HOH HOH H . 
D 4 HOH 44 344 345 HOH HOH H . 
D 4 HOH 45 345 344 HOH HOH H . 
D 4 HOH 46 346 346 HOH HOH H . 
D 4 HOH 47 347 347 HOH HOH H . 
D 4 HOH 48 348 348 HOH HOH H . 
D 4 HOH 49 349 349 HOH HOH H . 
D 4 HOH 50 350 350 HOH HOH H . 
D 4 HOH 51 351 351 HOH HOH H . 
D 4 HOH 52 352 352 HOH HOH H . 
D 4 HOH 53 353 353 HOH HOH H . 
D 4 HOH 54 354 354 HOH HOH H . 
D 4 HOH 55 355 355 HOH HOH H . 
D 4 HOH 56 356 356 HOH HOH H . 
D 4 HOH 57 357 357 HOH HOH H . 
D 4 HOH 58 358 358 HOH HOH H . 
D 4 HOH 59 359 359 HOH HOH H . 
D 4 HOH 60 360 360 HOH HOH H . 
D 4 HOH 61 361 361 HOH HOH H . 
D 4 HOH 62 362 362 HOH HOH H . 
E 4 HOH 1  301 303 HOH HOH L . 
E 4 HOH 2  302 301 HOH HOH L . 
E 4 HOH 3  303 302 HOH HOH L . 
E 4 HOH 4  304 304 HOH HOH L . 
E 4 HOH 5  305 306 HOH HOH L . 
E 4 HOH 6  306 305 HOH HOH L . 
E 4 HOH 7  307 307 HOH HOH L . 
E 4 HOH 8  308 308 HOH HOH L . 
E 4 HOH 9  309 309 HOH HOH L . 
E 4 HOH 10 310 312 HOH HOH L . 
E 4 HOH 11 311 310 HOH HOH L . 
E 4 HOH 12 312 311 HOH HOH L . 
E 4 HOH 13 313 313 HOH HOH L . 
E 4 HOH 14 314 315 HOH HOH L . 
E 4 HOH 15 315 314 HOH HOH L . 
E 4 HOH 16 316 316 HOH HOH L . 
E 4 HOH 17 317 317 HOH HOH L . 
E 4 HOH 18 318 320 HOH HOH L . 
E 4 HOH 19 319 318 HOH HOH L . 
E 4 HOH 20 320 319 HOH HOH L . 
E 4 HOH 21 321 321 HOH HOH L . 
E 4 HOH 22 322 324 HOH HOH L . 
E 4 HOH 23 323 323 HOH HOH L . 
E 4 HOH 24 324 322 HOH HOH L . 
E 4 HOH 25 325 325 HOH HOH L . 
E 4 HOH 26 326 327 HOH HOH L . 
E 4 HOH 27 327 326 HOH HOH L . 
E 4 HOH 28 328 330 HOH HOH L . 
E 4 HOH 29 329 334 HOH HOH L . 
E 4 HOH 30 330 329 HOH HOH L . 
E 4 HOH 31 331 331 HOH HOH L . 
E 4 HOH 32 332 332 HOH HOH L . 
E 4 HOH 33 333 333 HOH HOH L . 
E 4 HOH 34 334 337 HOH HOH L . 
E 4 HOH 35 335 336 HOH HOH L . 
E 4 HOH 36 336 328 HOH HOH L . 
E 4 HOH 37 337 341 HOH HOH L . 
E 4 HOH 38 338 335 HOH HOH L . 
E 4 HOH 39 339 338 HOH HOH L . 
E 4 HOH 40 340 339 HOH HOH L . 
E 4 HOH 41 341 340 HOH HOH L . 
E 4 HOH 42 342 343 HOH HOH L . 
E 4 HOH 43 343 344 HOH HOH L . 
E 4 HOH 44 344 342 HOH HOH L . 
E 4 HOH 45 345 345 HOH HOH L . 
E 4 HOH 46 346 348 HOH HOH L . 
E 4 HOH 47 347 347 HOH HOH L . 
E 4 HOH 48 348 349 HOH HOH L . 
E 4 HOH 49 349 351 HOH HOH L . 
E 4 HOH 50 350 350 HOH HOH L . 
E 4 HOH 51 351 352 HOH HOH L . 
E 4 HOH 52 352 346 HOH HOH L . 
E 4 HOH 53 353 353 HOH HOH L . 
E 4 HOH 54 354 354 HOH HOH L . 
E 4 HOH 55 355 355 HOH HOH L . 
E 4 HOH 56 356 356 HOH HOH L . 
E 4 HOH 57 357 358 HOH HOH L . 
E 4 HOH 58 358 357 HOH HOH L . 
E 4 HOH 59 359 359 HOH HOH L . 
E 4 HOH 60 360 360 HOH HOH L . 
E 4 HOH 61 361 361 HOH HOH L . 
F 4 HOH 1  101 101 HOH HOH A . 
F 4 HOH 2  102 102 HOH HOH A . 
F 4 HOH 3  103 103 HOH HOH A . 
F 4 HOH 4  104 104 HOH HOH A . 
F 4 HOH 5  105 105 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0135 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XS1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     43.880 
_cell.length_a_esd                 ? 
_cell.length_b                     67.489 
_cell.length_b_esd                 ? 
_cell.length_c                     138.655 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XS1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XS1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.96 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.26 
_exptl_crystal.description                  'Plate-like crystal' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              3.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.07 M Citric acid, 0.03 M BIS-TRIS propane, 16% Polyethylene glycol 3,350, by using random Microseed Matrix Screening (rMMS) method
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            297 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 270' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2015-12-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Numerical link type Si(111) double crystal' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE AR-NW12A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   AR-NW12A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8XS1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               50.0 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18912 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.1 
_reflns.pdbx_netI_over_av_sigmaI                       10.6 
_reflns.pdbx_netI_over_sigmaI                          5.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.165 
_reflns.pdbx_Rpim_I_all                                0.066 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.151 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.30 2.38  ? 2.60 ? ? ? ? 1834 ? ? ? ? ? ? ? ? ? ? ? 6.5 1.003 ? ? 0.835 0.320 ? 1  1 0.836 0.954 ? 99.6 ? 0.769 ? ? ? ? ? ? ? ? ? 
2.38 2.48  ? 2.88 ? ? ? ? 1859 ? ? ? ? ? ? ? ? ? ? ? 6.4 1.017 ? ? 0.743 0.287 ? 2  1 0.882 0.968 ? 99.4 ? 0.683 ? ? ? ? ? ? ? ? ? 
2.48 2.59  ? 3.30 ? ? ? ? 1886 ? ? ? ? ? ? ? ? ? ? ? 6.3 0.998 ? ? 0.610 0.237 ? 3  1 0.916 0.978 ? 99.4 ? 0.560 ? ? ? ? ? ? ? ? ? 
2.59 2.73  ? 4.03 ? ? ? ? 1861 ? ? ? ? ? ? ? ? ? ? ? 6.3 0.995 ? ? 0.479 0.186 ? 4  1 0.947 0.986 ? 99.4 ? 0.440 ? ? ? ? ? ? ? ? ? 
2.73 2.90  ? 4.48 ? ? ? ? 1860 ? ? ? ? ? ? ? ? ? ? ? 6.2 1.003 ? ? 0.405 0.159 ? 5  1 0.940 0.984 ? 99.2 ? 0.371 ? ? ? ? ? ? ? ? ? 
2.90 3.12  ? 6.02 ? ? ? ? 1863 ? ? ? ? ? ? ? ? ? ? ? 6.1 1.000 ? ? 0.281 0.111 ? 6  1 0.967 0.992 ? 98.7 ? 0.257 ? ? ? ? ? ? ? ? ? 
3.12 3.44  ? 9.43 ? ? ? ? 1877 ? ? ? ? ? ? ? ? ? ? ? 6.0 1.018 ? ? 0.182 0.072 ? 7  1 0.977 0.994 ? 98.5 ? 0.166 ? ? ? ? ? ? ? ? ? 
3.44 3.93  ? 12.0 ? ? ? ? 1881 ? ? ? ? ? ? ? ? ? ? ? 5.8 1.020 ? ? 0.130 0.053 ? 8  1 0.985 0.996 ? 98.1 ? 0.118 ? ? ? ? ? ? ? ? ? 
3.93 4.95  ? 16.7 ? ? ? ? 1927 ? ? ? ? ? ? ? ? ? ? ? 5.6 1.014 ? ? 0.092 0.038 ? 9  1 0.992 0.998 ? 99.1 ? 0.083 ? ? ? ? ? ? ? ? ? 
4.95 50.00 ? 21.7 ? ? ? ? 2064 ? ? ? ? ? ? ? ? ? ? ? 5.8 1.021 ? ? 0.081 0.033 ? 10 1 0.994 0.998 ? 99.4 ? 0.073 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            -3.37 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            1.69 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            1.68 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               39.498 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.946 
_refine.correlation_coeff_Fo_to_Fc_free          0.920 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XS1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             50.0 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17875 
_refine.ls_number_reflns_R_free                  984 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.85 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20143 
_refine.ls_R_factor_R_free                       0.24781 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.19897 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5X5X 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.429 
_refine.pdbx_overall_ESU_R_Free                  0.255 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             8.847 
_refine.overall_SU_ML                            0.206 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        50.0 
_refine_hist.number_atoms_solvent             128 
_refine_hist.number_atoms_total               3447 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3319 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.011  0.019  3402 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  3108 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.654  1.949  4626 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.979  3.000  7214 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.489  5.000  435  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 37.267 24.729 129  ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 16.193 15.000 544  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.208 15.000 8    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.087  0.200  522  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.021  3844 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  754  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.486  3.821  1749 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.487  3.822  1748 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 3.895  5.720  2181 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 3.894  5.719  2182 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 2.873  4.080  1653 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.872  4.080  1653 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.656  5.973  2445 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.403  30.519 3658 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 7.401  30.517 3658 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.30 
_refine_ls_shell.d_res_low                        2.357 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             65 
_refine_ls_shell.number_reflns_R_work             1268 
_refine_ls_shell.percent_reflns_obs               96.59 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.284 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.342 
# 
_struct.entry_id                     8XS1 
_struct.title                        
'Crystal structure of Fab fragment of anti-osteocalcin antibody KTM219 complexed with C-terminal peptide antigen' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XS1 
_struct_keywords.text            
'Antibody, Immunoglobulin fold, Osteocalcin, Quenchbody (Q-body), Open sandwich immunoassay, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8XS1        8XS1   ? 1 ?       1  
2 PDB 8XS1        8XS1   ? 2 ?       1  
3 UNP OSTCN_HUMAN P02818 ? 3 RRFYGPV 94 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XS1 H 1 ? 249 ? 8XS1   -3 ? 242 ? -3 242 
2 2 8XS1 L 1 ? 232 ? 8XS1   -1 ? 225 ? -1 225 
3 3 8XS1 A 1 ? 7   ? P02818 94 ? 100 ? 43 49  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4680  ? 
1 MORE         -29   ? 
1 'SSA (A^2)'  19540 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 29  ? TYR A 36  ? SER H 25  TYR H 32  1 ? 8 
HELX_P HELX_P2  AA2 GLN A 66  ? LYS A 69  ? GLN H 61  LYS H 64  5 ? 4 
HELX_P HELX_P3  AA3 LYS A 78  ? SER A 80  ? LYS H 73  SER H 75  5 ? 3 
HELX_P HELX_P4  AA4 THR A 91  ? SER A 95  ? THR H 83  SER H 87  5 ? 5 
HELX_P HELX_P5  AA5 SER A 134 ? THR A 138 ? SER H 127 THR H 131 5 ? 5 
HELX_P HELX_P6  AA6 SER A 163 ? SER A 168 ? SER H 156 SER H 161 5 ? 6 
HELX_P HELX_P7  AA7 SER A 194 ? GLN A 199 ? SER H 187 GLN H 192 1 ? 6 
HELX_P HELX_P8  AA8 LYS A 208 ? ASN A 211 ? LYS H 201 ASN H 204 5 ? 4 
HELX_P HELX_P9  AA9 GLU B 86  ? LEU B 90  ? GLU L 79  LEU L 83  5 ? 5 
HELX_P HELX_P10 AB1 SER B 128 ? SER B 134 ? SER L 121 SER L 127 1 ? 7 
HELX_P HELX_P11 AB2 LYS B 190 ? LYS B 195 ? LYS L 183 LYS L 188 1 ? 6 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 26  SG ? ? ? 1_555 A CYS 100 SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.089 ? ? 
disulf2 disulf ? ? A CYS 147 SG ? ? ? 1_555 A CYS 203 SG ? ? H CYS 140 H CYS 196 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf3 disulf ? ? B CYS 25  SG ? ? ? 1_555 B CYS 95  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.053 ? ? 
disulf4 disulf ? ? B CYS 141 SG ? ? ? 1_555 B CYS 201 SG ? ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.024 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 26  ? CYS A 100 ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 147 ? CYS A 203 ? CYS H 140 ? 1_555 CYS H 196 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 25  ? CYS B 95  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 141 ? CYS B 201 ? CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 153 A . ? PHE 146 H PRO 154 A ? PRO 147 H 1 -4.42 
2 GLU 155 A . ? GLU 148 H PRO 156 A ? PRO 149 H 1 -2.86 
3 SER 9   B . ? SER 7   L PRO 10  B ? PRO 8   L 1 -4.80 
4 VAL 101 B . ? VAL 94  L PRO 102 B ? PRO 95  L 1 -0.15 
5 TYR 147 B . ? TYR 140 L PRO 148 B ? PRO 141 L 1 -3.93 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 3 ? 
AA7 ? 4 ? 
AA8 ? 6 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
AA8 5 6 ? anti-parallel 
AA9 1 2 ? parallel      
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 9   ? GLN A 10  ? GLN H 5   GLN H 6   
AA1 2 VAL A 22  ? LYS A 27  ? VAL H 18  LYS H 23  
AA1 3 THR A 82  ? LEU A 87  ? THR H 77  LEU H 82  
AA1 4 ALA A 72  ? ASP A 77  ? ALA H 67  ASP H 72  
AA2 1 GLU A 14  ? VAL A 16  ? GLU H 10  VAL H 12  
AA2 2 THR A 114 ? VAL A 118 ? THR H 107 VAL H 111 
AA2 3 ALA A 96  ? SER A 103 ? ALA H 88  SER H 95  
AA2 4 TRP A 37  ? SER A 44  ? TRP H 33  SER H 40  
AA2 5 GLY A 48  ? ILE A 55  ? GLY H 44  ILE H 51  
AA2 6 SER A 62  ? TYR A 64  ? SER H 57  TYR H 59  
AA3 1 GLU A 14  ? VAL A 16  ? GLU H 10  VAL H 12  
AA3 2 THR A 114 ? VAL A 118 ? THR H 107 VAL H 111 
AA3 3 ALA A 96  ? SER A 103 ? ALA H 88  SER H 95  
AA3 4 SER A 109 ? TRP A 110 ? SER H 102 TRP H 103 
AA4 1 SER A 127 ? LEU A 131 ? SER H 120 LEU H 124 
AA4 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA4 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA4 4 HIS A 171 ? THR A 172 ? HIS H 164 THR H 165 
AA5 1 SER A 127 ? LEU A 131 ? SER H 120 LEU H 124 
AA5 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA5 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA5 4 VAL A 176 ? LEU A 177 ? VAL H 169 LEU H 170 
AA6 1 THR A 158 ? TRP A 161 ? THR H 151 TRP H 154 
AA6 2 ILE A 202 ? HIS A 207 ? ILE H 195 HIS H 200 
AA6 3 THR A 212 ? LYS A 217 ? THR H 205 LYS H 210 
AA7 1 LEU B 6   ? SER B 9   ? LEU L 4   SER L 7   
AA7 2 ALA B 21  ? SER B 27  ? ALA L 19  SER L 25  
AA7 3 ASP B 77  ? ILE B 82  ? ASP L 70  ILE L 75  
AA7 4 PHE B 69  ? SER B 74  ? PHE L 62  SER L 67  
AA8 1 SER B 12  ? VAL B 15  ? SER L 10  VAL L 13  
AA8 2 THR B 109 ? ILE B 113 ? THR L 102 ILE L 106 
AA8 3 GLY B 91  ? GLN B 97  ? GLY L 84  GLN L 90  
AA8 4 LEU B 40  ? GLN B 45  ? LEU L 33  GLN L 38  
AA8 5 LYS B 52  ? TYR B 56  ? LYS L 45  TYR L 49  
AA8 6 ASN B 60  ? ARG B 61  ? ASN L 53  ARG L 54  
AA9 1 SER B 12  ? VAL B 15  ? SER L 10  VAL L 13  
AA9 2 THR B 109 ? ILE B 113 ? THR L 102 ILE L 106 
AA9 3 GLY B 91  ? GLN B 97  ? GLY L 84  GLN L 90  
AA9 4 THR B 104 ? PHE B 105 ? THR L 97  PHE L 98  
AB1 1 SER B 121 ? PHE B 125 ? SER L 114 PHE L 118 
AB1 2 THR B 136 ? PHE B 146 ? THR L 129 PHE L 139 
AB1 3 TYR B 180 ? SER B 189 ? TYR L 173 SER L 182 
AB1 4 SER B 166 ? VAL B 170 ? SER L 159 VAL L 163 
AB2 1 ALA B 160 ? LEU B 161 ? ALA L 153 LEU L 154 
AB2 2 LYS B 152 ? VAL B 157 ? LYS L 145 VAL L 150 
AB2 3 VAL B 198 ? THR B 204 ? VAL L 191 THR L 197 
AB2 4 VAL B 212 ? ASN B 217 ? VAL L 205 ASN L 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 9   ? N GLN H 5   O LYS A 27  ? O LYS H 23  
AA1 2 3 N CYS A 26  ? N CYS H 22  O ALA A 83  ? O ALA H 78  
AA1 3 4 O TYR A 84  ? O TYR H 79  N THR A 75  ? N THR H 70  
AA2 1 2 N VAL A 16  ? N VAL H 12  O THR A 117 ? O THR H 110 
AA2 2 3 O VAL A 116 ? O VAL H 109 N ALA A 96  ? N ALA H 88  
AA2 3 4 O TYR A 99  ? O TYR H 91  N VAL A 41  ? N VAL H 37  
AA2 4 5 N LYS A 42  ? N LYS H 38  O GLU A 50  ? O GLU H 46  
AA2 5 6 N GLU A 54  ? N GLU H 50  O ASN A 63  ? O ASN H 58  
AA3 1 2 N VAL A 16  ? N VAL H 12  O THR A 117 ? O THR H 110 
AA3 2 3 O VAL A 116 ? O VAL H 109 N ALA A 96  ? N ALA H 88  
AA3 3 4 N SER A 102 ? N SER H 94  O SER A 109 ? O SER H 102 
AA4 1 2 N LEU A 131 ? N LEU H 124 O GLY A 146 ? O GLY H 139 
AA4 2 3 N ALA A 143 ? N ALA H 136 O VAL A 191 ? O VAL H 184 
AA4 3 4 O VAL A 188 ? O VAL H 181 N HIS A 171 ? N HIS H 164 
AA5 1 2 N LEU A 131 ? N LEU H 124 O GLY A 146 ? O GLY H 139 
AA5 2 3 N ALA A 143 ? N ALA H 136 O VAL A 191 ? O VAL H 184 
AA5 3 4 O SER A 184 ? O SER H 177 N VAL A 176 ? N VAL H 169 
AA6 1 2 N SER A 160 ? N SER H 153 O ASN A 204 ? O ASN H 197 
AA6 2 3 N VAL A 205 ? N VAL H 198 O VAL A 214 ? O VAL H 207 
AA7 1 2 N THR B 7   ? N THR L 5   O THR B 26  ? O THR L 24  
AA7 2 3 N ILE B 23  ? N ILE L 21  O LEU B 80  ? O LEU L 73  
AA7 3 4 O LYS B 81  ? O LYS L 74  N SER B 70  ? N SER L 63  
AA8 1 2 N LEU B 13  ? N LEU L 11  O LYS B 110 ? O LYS L 103 
AA8 2 3 O THR B 109 ? O THR L 102 N TYR B 93  ? N TYR L 86  
AA8 3 4 O ILE B 92  ? O ILE L 85  N GLN B 45  ? N GLN L 38  
AA8 4 5 N TRP B 42  ? N TRP L 35  O LEU B 54  ? O LEU L 47  
AA8 5 6 N TYR B 56  ? N TYR L 49  O ASN B 60  ? O ASN L 53  
AA9 1 2 N LEU B 13  ? N LEU L 11  O LYS B 110 ? O LYS L 103 
AA9 2 3 O THR B 109 ? O THR L 102 N TYR B 93  ? N TYR L 86  
AA9 3 4 N GLN B 97  ? N GLN L 90  O THR B 104 ? O THR L 97  
AB1 1 2 N PHE B 123 ? N PHE L 116 O LEU B 142 ? O LEU L 135 
AB1 2 3 N CYS B 141 ? N CYS L 134 O SER B 184 ? O SER L 177 
AB1 3 4 O THR B 185 ? O THR L 178 N GLN B 167 ? N GLN L 160 
AB2 1 2 O ALA B 160 ? O ALA L 153 N VAL B 157 ? N VAL L 150 
AB2 2 3 N GLN B 154 ? N GLN L 147 O GLU B 202 ? O GLU L 195 
AB2 3 4 N VAL B 203 ? N VAL L 196 O VAL B 212 ? O VAL L 205 
# 
_pdbx_entry_details.entry_id                   8XS1 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP H 144 ? ? 61.44   63.70  
2 1 THR L 50  ? ? 29.62   60.63  
3 1 LEU L 51  ? ? 86.88   -60.93 
4 1 SER L 52  ? ? -142.96 12.57  
5 1 SER L 67  ? ? 178.23  168.11 
6 1 ASN L 138 ? ? 59.52   70.61  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 H MET -3  ? A MET 1   
2  1 Y 1 H ALA -2  ? A ALA 2   
3  1 Y 1 H THR -1  ? A THR 3   
4  1 Y 1 H GLY 0   ? A GLY 4   
5  1 Y 1 H GLN 1   ? A GLN 5   
6  1 Y 1 H VAL 2   ? A VAL 6   
7  1 Y 1 H LYS 214 ? A LYS 221 
8  1 Y 1 H SER 215 ? A SER 222 
9  1 Y 1 H ALA 216 ? A ALA 223 
10 1 Y 1 H SER 217 ? A SER 224 
11 1 Y 1 H ALA 218 ? A ALA 225 
12 1 Y 1 H ALA 219 ? A ALA 226 
13 1 Y 1 H HIS 220 ? A HIS 227 
14 1 Y 1 H HIS 221 ? A HIS 228 
15 1 Y 1 H HIS 222 ? A HIS 229 
16 1 Y 1 H HIS 223 ? A HIS 230 
17 1 Y 1 H HIS 224 ? A HIS 231 
18 1 Y 1 H HIS 225 ? A HIS 232 
19 1 Y 1 H GLY 226 ? A GLY 233 
20 1 Y 1 H ALA 227 ? A ALA 234 
21 1 Y 1 H ALA 228 ? A ALA 235 
22 1 Y 1 H GLU 229 ? A GLU 236 
23 1 Y 1 H GLN 230 ? A GLN 237 
24 1 Y 1 H LYS 231 ? A LYS 238 
25 1 Y 1 H LEU 232 ? A LEU 239 
26 1 Y 1 H ILE 233 ? A ILE 240 
27 1 Y 1 H SER 234 ? A SER 241 
28 1 Y 1 H GLU 235 ? A GLU 242 
29 1 Y 1 H GLU 236 ? A GLU 243 
30 1 Y 1 H ASP 237 ? A ASP 244 
31 1 Y 1 H LEU 238 ? A LEU 245 
32 1 Y 1 H ASN 239 ? A ASN 246 
33 1 Y 1 H GLY 240 ? A GLY 247 
34 1 Y 1 H ALA 241 ? A ALA 248 
35 1 Y 1 H ALA 242 ? A ALA 249 
36 1 Y 1 L MET -1  ? B MET 1   
37 1 Y 1 L GLY 212 ? B GLY 219 
38 1 Y 1 L GLU 213 ? B GLU 220 
39 1 Y 1 L GLY 214 ? B GLY 221 
40 1 Y 1 L GLY 215 ? B GLY 222 
41 1 Y 1 L GLY 216 ? B GLY 223 
42 1 Y 1 L SER 217 ? B SER 224 
43 1 Y 1 L ASP 218 ? B ASP 225 
44 1 Y 1 L TYR 219 ? B TYR 226 
45 1 Y 1 L LYS 220 ? B LYS 227 
46 1 Y 1 L ASP 221 ? B ASP 228 
47 1 Y 1 L ASP 222 ? B ASP 229 
48 1 Y 1 L ASP 223 ? B ASP 230 
49 1 Y 1 L ASP 224 ? B ASP 231 
50 1 Y 1 L LYS 225 ? B LYS 232 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)'                      Japan 
'JP19H02522, JP17KK0104, JP16K05841, JP16H00761, JP24780097, JP15H04191, JP18H03851, JP24K01267' 1 
'Ministry of Education, Culture, Sports, Science and Technology (Japan)' Japan 
'Cooperative Research Program of Network Joint Research Center for Materials and Devices'        2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5X5X 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8XS1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022789 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014817 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007212 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS A 1 7   ? 60.562 64.582  19.958  1.00 75.87  ? 3   LYS H N   1 
ATOM   2    C CA  . LYS A 1 7   ? 59.693 63.797  19.025  1.00 75.24  ? 3   LYS H CA  1 
ATOM   3    C C   . LYS A 1 7   ? 58.260 63.665  19.576  1.00 68.32  ? 3   LYS H C   1 
ATOM   4    O O   . LYS A 1 7   ? 57.905 62.666  20.229  1.00 60.12  ? 3   LYS H O   1 
ATOM   5    C CB  . LYS A 1 7   ? 60.289 62.415  18.771  1.00 88.16  ? 3   LYS H CB  1 
ATOM   6    C CG  . LYS A 1 7   ? 61.666 62.419  18.132  1.00 98.18  ? 3   LYS H CG  1 
ATOM   7    C CD  . LYS A 1 7   ? 62.186 61.000  17.968  1.00 103.24 ? 3   LYS H CD  1 
ATOM   8    C CE  . LYS A 1 7   ? 63.500 60.982  17.209  1.00 107.94 ? 3   LYS H CE  1 
ATOM   9    N NZ  . LYS A 1 7   ? 63.817 59.621  16.695  1.00 114.25 ? 3   LYS H NZ  1 
ATOM   10   N N   . LEU A 1 8   ? 57.464 64.704  19.331  1.00 56.56  ? 4   LEU H N   1 
ATOM   11   C CA  . LEU A 1 8   ? 56.059 64.739  19.719  1.00 51.45  ? 4   LEU H CA  1 
ATOM   12   C C   . LEU A 1 8   ? 55.263 64.998  18.477  1.00 49.84  ? 4   LEU H C   1 
ATOM   13   O O   . LEU A 1 8   ? 55.767 65.638  17.564  1.00 56.98  ? 4   LEU H O   1 
ATOM   14   C CB  . LEU A 1 8   ? 55.787 65.849  20.721  1.00 50.41  ? 4   LEU H CB  1 
ATOM   15   C CG  . LEU A 1 8   ? 56.410 65.672  22.098  1.00 50.71  ? 4   LEU H CG  1 
ATOM   16   C CD1 . LEU A 1 8   ? 56.117 66.901  22.940  1.00 51.94  ? 4   LEU H CD1 1 
ATOM   17   C CD2 . LEU A 1 8   ? 55.918 64.433  22.820  1.00 50.69  ? 4   LEU H CD2 1 
ATOM   18   N N   . GLN A 1 9   ? 54.021 64.531  18.449  1.00 41.95  ? 5   GLN H N   1 
ATOM   19   C CA  . GLN A 1 9   ? 53.184 64.619  17.254  1.00 45.37  ? 5   GLN H CA  1 
ATOM   20   C C   . GLN A 1 9   ? 51.688 64.747  17.623  1.00 42.88  ? 5   GLN H C   1 
ATOM   21   O O   . GLN A 1 9   ? 51.073 63.787  18.098  1.00 40.20  ? 5   GLN H O   1 
ATOM   22   C CB  . GLN A 1 9   ? 53.434 63.380  16.362  1.00 51.83  ? 5   GLN H CB  1 
ATOM   23   C CG  . GLN A 1 9   ? 52.816 63.469  14.957  1.00 59.49  ? 5   GLN H CG  1 
ATOM   24   C CD  . GLN A 1 9   ? 53.475 62.537  13.922  1.00 64.24  ? 5   GLN H CD  1 
ATOM   25   O OE1 . GLN A 1 9   ? 53.406 61.311  14.037  1.00 67.05  ? 5   GLN H OE1 1 
ATOM   26   N NE2 . GLN A 1 9   ? 54.099 63.123  12.897  1.00 64.72  ? 5   GLN H NE2 1 
ATOM   27   N N   . GLN A 1 10  ? 51.115 65.922  17.370  1.00 40.29  ? 6   GLN H N   1 
ATOM   28   C CA  . GLN A 1 10  ? 49.756 66.246  17.798  1.00 41.14  ? 6   GLN H CA  1 
ATOM   29   C C   . GLN A 1 10  ? 48.720 66.183  16.684  1.00 41.88  ? 6   GLN H C   1 
ATOM   30   O O   . GLN A 1 10  ? 49.004 66.531  15.540  1.00 43.57  ? 6   GLN H O   1 
ATOM   31   C CB  . GLN A 1 10  ? 49.733 67.617  18.475  1.00 38.08  ? 6   GLN H CB  1 
ATOM   32   C CG  . GLN A 1 10  ? 50.210 67.553  19.926  1.00 36.43  ? 6   GLN H CG  1 
ATOM   33   C CD  . GLN A 1 10  ? 50.064 68.873  20.648  1.00 35.74  ? 6   GLN H CD  1 
ATOM   34   O OE1 . GLN A 1 10  ? 51.037 69.581  20.878  1.00 33.11  ? 6   GLN H OE1 1 
ATOM   35   N NE2 . GLN A 1 10  ? 48.841 69.214  21.003  1.00 35.42  ? 6   GLN H NE2 1 
ATOM   36   N N   . SER A 1 11  ? 47.510 65.747  17.042  1.00 44.60  ? 7   SER H N   1 
ATOM   37   C CA  . SER A 1 11  ? 46.427 65.568  16.072  1.00 45.02  ? 7   SER H CA  1 
ATOM   38   C C   . SER A 1 11  ? 45.991 66.884  15.419  1.00 45.08  ? 7   SER H C   1 
ATOM   39   O O   . SER A 1 11  ? 46.288 67.994  15.907  1.00 41.46  ? 7   SER H O   1 
ATOM   40   C CB  . SER A 1 11  ? 45.216 64.844  16.680  1.00 43.07  ? 7   SER H CB  1 
ATOM   41   O OG  . SER A 1 11  ? 44.831 65.400  17.912  1.00 41.76  ? 7   SER H OG  1 
ATOM   42   N N   . GLY A 1 12  ? 45.300 66.723  14.290  1.00 45.66  ? 8   GLY H N   1 
ATOM   43   C CA  . GLY A 1 12  ? 44.958 67.833  13.395  1.00 42.27  ? 8   GLY H CA  1 
ATOM   44   C C   . GLY A 1 12  ? 43.920 68.766  13.983  1.00 40.45  ? 8   GLY H C   1 
ATOM   45   O O   . GLY A 1 12  ? 43.285 68.430  15.008  1.00 36.17  ? 8   GLY H O   1 
ATOM   46   N N   . ALA A 1 13  ? 43.761 69.937  13.338  1.00 38.74  ? 9   ALA H N   1 
ATOM   47   C CA  . ALA A 1 13  ? 42.786 70.937  13.773  1.00 37.42  ? 9   ALA H CA  1 
ATOM   48   C C   . ALA A 1 13  ? 41.380 70.347  13.802  1.00 37.52  ? 9   ALA H C   1 
ATOM   49   O O   . ALA A 1 13  ? 41.039 69.502  12.986  1.00 37.92  ? 9   ALA H O   1 
ATOM   50   C CB  . ALA A 1 13  ? 42.829 72.176  12.902  1.00 38.33  ? 9   ALA H CB  1 
ATOM   51   N N   . GLU A 1 14  ? 40.608 70.793  14.780  1.00 39.70  ? 10  GLU H N   1 
ATOM   52   C CA  . GLU A 1 14  ? 39.228 70.413  14.995  1.00 41.20  ? 10  GLU H CA  1 
ATOM   53   C C   . GLU A 1 14  ? 38.362 71.665  14.853  1.00 43.69  ? 10  GLU H C   1 
ATOM   54   O O   . GLU A 1 14  ? 38.722 72.745  15.365  1.00 43.07  ? 10  GLU H O   1 
ATOM   55   C CB  . GLU A 1 14  ? 39.075 69.890  16.419  1.00 42.56  ? 10  GLU H CB  1 
ATOM   56   C CG  . GLU A 1 14  ? 39.920 68.675  16.756  1.00 41.95  ? 10  GLU H CG  1 
ATOM   57   C CD  . GLU A 1 14  ? 39.269 67.381  16.335  1.00 43.52  ? 10  GLU H CD  1 
ATOM   58   O OE1 . GLU A 1 14  ? 38.258 67.436  15.600  1.00 44.64  ? 10  GLU H OE1 1 
ATOM   59   O OE2 . GLU A 1 14  ? 39.769 66.307  16.740  1.00 43.15  ? 10  GLU H OE2 1 
ATOM   60   N N   . PHE A 1 15  ? 37.238 71.518  14.150  1.00 44.08  ? 11  PHE H N   1 
ATOM   61   C CA  . PHE A 1 15  ? 36.243 72.586  13.982  1.00 46.48  ? 11  PHE H CA  1 
ATOM   62   C C   . PHE A 1 15  ? 34.933 71.948  14.375  1.00 43.98  ? 11  PHE H C   1 
ATOM   63   O O   . PHE A 1 15  ? 34.460 71.030  13.692  1.00 43.99  ? 11  PHE H O   1 
ATOM   64   C CB  . PHE A 1 15  ? 36.182 73.103  12.555  1.00 50.84  ? 11  PHE H CB  1 
ATOM   65   C CG  . PHE A 1 15  ? 37.517 73.490  12.000  1.00 58.70  ? 11  PHE H CG  1 
ATOM   66   C CD1 . PHE A 1 15  ? 38.328 72.535  11.365  1.00 63.84  ? 11  PHE H CD1 1 
ATOM   67   C CD2 . PHE A 1 15  ? 37.972 74.800  12.096  1.00 62.95  ? 11  PHE H CD2 1 
ATOM   68   C CE1 . PHE A 1 15  ? 39.568 72.882  10.840  1.00 66.10  ? 11  PHE H CE1 1 
ATOM   69   C CE2 . PHE A 1 15  ? 39.217 75.153  11.578  1.00 66.98  ? 11  PHE H CE2 1 
ATOM   70   C CZ  . PHE A 1 15  ? 40.015 74.195  10.952  1.00 65.80  ? 11  PHE H CZ  1 
ATOM   71   N N   . VAL A 1 16  ? 34.380 72.396  15.504  1.00 40.93  ? 12  VAL H N   1 
ATOM   72   C CA  . VAL A 1 16  ? 33.322 71.669  16.180  1.00 38.37  ? 12  VAL H CA  1 
ATOM   73   C C   . VAL A 1 16  ? 32.155 72.534  16.637  1.00 37.43  ? 12  VAL H C   1 
ATOM   74   O O   . VAL A 1 16  ? 32.287 73.765  16.800  1.00 33.61  ? 12  VAL H O   1 
ATOM   75   C CB  . VAL A 1 16  ? 33.891 70.853  17.346  1.00 40.44  ? 12  VAL H CB  1 
ATOM   76   C CG1 . VAL A 1 16  ? 34.832 69.779  16.812  1.00 41.12  ? 12  VAL H CG1 1 
ATOM   77   C CG2 . VAL A 1 16  ? 34.606 71.738  18.341  1.00 41.07  ? 12  VAL H CG2 1 
ATOM   78   N N   . LYS A 1 17  ? 30.996 71.880  16.781  1.00 36.95  ? 13  LYS H N   1 
ATOM   79   C CA  . LYS A 1 17  ? 29.804 72.537  17.335  1.00 38.42  ? 13  LYS H CA  1 
ATOM   80   C C   . LYS A 1 17  ? 29.952 72.648  18.839  1.00 36.39  ? 13  LYS H C   1 
ATOM   81   O O   . LYS A 1 17  ? 30.668 71.855  19.484  1.00 31.90  ? 13  LYS H O   1 
ATOM   82   C CB  . LYS A 1 17  ? 28.489 71.803  17.018  1.00 40.42  ? 13  LYS H CB  1 
ATOM   83   C CG  . LYS A 1 17  ? 28.405 70.377  17.566  1.00 49.18  ? 13  LYS H CG  1 
ATOM   84   C CD  . LYS A 1 17  ? 26.975 69.874  17.693  1.00 57.07  ? 13  LYS H CD  1 
ATOM   85   C CE  . LYS A 1 17  ? 26.950 68.506  18.372  1.00 60.77  ? 13  LYS H CE  1 
ATOM   86   N NZ  . LYS A 1 17  ? 25.782 67.705  17.916  1.00 63.49  ? 13  LYS H NZ  1 
ATOM   87   N N   . ALA A 1 18  ? 29.246 73.623  19.389  1.00 36.17  ? 14  ALA H N   1 
ATOM   88   C CA  . ALA A 1 18  ? 29.084 73.743  20.829  1.00 36.15  ? 14  ALA H CA  1 
ATOM   89   C C   . ALA A 1 18  ? 28.280 72.554  21.363  1.00 37.60  ? 14  ALA H C   1 
ATOM   90   O O   . ALA A 1 18  ? 27.310 72.126  20.750  1.00 39.03  ? 14  ALA H O   1 
ATOM   91   C CB  . ALA A 1 18  ? 28.380 75.042  21.153  1.00 35.36  ? 14  ALA H CB  1 
ATOM   92   N N   . GLY A 1 19  ? 28.688 72.038  22.517  1.00 38.63  ? 15  GLY H N   1 
ATOM   93   C CA  . GLY A 1 19  ? 28.143 70.798  23.057  1.00 36.19  ? 15  GLY H CA  1 
ATOM   94   C C   . GLY A 1 19  ? 28.850 69.541  22.607  1.00 34.77  ? 15  GLY H C   1 
ATOM   95   O O   . GLY A 1 19  ? 28.543 68.481  23.087  1.00 34.18  ? 15  GLY H O   1 
ATOM   96   N N   . ALA A 1 20  ? 29.830 69.670  21.719  1.00 37.80  ? 16  ALA H N   1 
ATOM   97   C CA  . ALA A 1 20  ? 30.597 68.546  21.242  1.00 38.15  ? 16  ALA H CA  1 
ATOM   98   C C   . ALA A 1 20  ? 31.622 68.120  22.268  1.00 39.62  ? 16  ALA H C   1 
ATOM   99   O O   . ALA A 1 20  ? 31.874 68.797  23.274  1.00 41.53  ? 16  ALA H O   1 
ATOM   100  C CB  . ALA A 1 20  ? 31.292 68.867  19.911  1.00 38.72  ? 16  ALA H CB  1 
ATOM   101  N N   . SER A 1 21  ? 32.158 66.943  21.971  1.00 40.40  ? 17  SER H N   1 
ATOM   102  C CA  . SER A 1 21  ? 33.279 66.335  22.610  1.00 40.76  ? 17  SER H CA  1 
ATOM   103  C C   . SER A 1 21  ? 34.304 66.061  21.512  1.00 42.11  ? 17  SER H C   1 
ATOM   104  O O   . SER A 1 21  ? 33.935 65.770  20.367  1.00 41.67  ? 17  SER H O   1 
ATOM   105  C CB  . SER A 1 21  ? 32.831 65.037  23.244  1.00 40.83  ? 17  SER H CB  1 
ATOM   106  O OG  . SER A 1 21  ? 32.499 65.245  24.588  1.00 41.91  ? 17  SER H OG  1 
ATOM   107  N N   . VAL A 1 22  ? 35.581 66.214  21.848  1.00 42.52  ? 18  VAL H N   1 
ATOM   108  C CA  . VAL A 1 22  ? 36.674 65.873  20.950  1.00 44.40  ? 18  VAL H CA  1 
ATOM   109  C C   . VAL A 1 22  ? 37.807 65.309  21.765  1.00 45.70  ? 18  VAL H C   1 
ATOM   110  O O   . VAL A 1 22  ? 38.128 65.814  22.845  1.00 50.59  ? 18  VAL H O   1 
ATOM   111  C CB  . VAL A 1 22  ? 37.268 67.064  20.147  1.00 47.54  ? 18  VAL H CB  1 
ATOM   112  C CG1 . VAL A 1 22  ? 36.213 67.723  19.307  1.00 50.95  ? 18  VAL H CG1 1 
ATOM   113  C CG2 . VAL A 1 22  ? 37.940 68.102  21.039  1.00 47.74  ? 18  VAL H CG2 1 
ATOM   114  N N   . LYS A 1 23  ? 38.424 64.284  21.215  1.00 41.40  ? 19  LYS H N   1 
ATOM   115  C CA  . LYS A 1 23  ? 39.580 63.693  21.776  1.00 40.92  ? 19  LYS H CA  1 
ATOM   116  C C   . LYS A 1 23  ? 40.761 64.197  20.966  1.00 39.12  ? 19  LYS H C   1 
ATOM   117  O O   . LYS A 1 23  ? 40.801 63.956  19.774  1.00 40.08  ? 19  LYS H O   1 
ATOM   118  C CB  . LYS A 1 23  ? 39.434 62.190  21.630  1.00 43.21  ? 19  LYS H CB  1 
ATOM   119  C CG  . LYS A 1 23  ? 40.455 61.385  22.404  1.00 46.72  ? 19  LYS H CG  1 
ATOM   120  C CD  . LYS A 1 23  ? 40.187 59.892  22.260  1.00 48.09  ? 19  LYS H CD  1 
ATOM   121  C CE  . LYS A 1 23  ? 40.404 59.420  20.832  1.00 48.14  ? 19  LYS H CE  1 
ATOM   122  N NZ  . LYS A 1 23  ? 40.216 57.954  20.700  1.00 48.09  ? 19  LYS H NZ  1 
ATOM   123  N N   . LEU A 1 24  ? 41.696 64.911  21.596  1.00 35.47  ? 20  LEU H N   1 
ATOM   124  C CA  . LEU A 1 24  ? 42.937 65.322  20.929  1.00 36.62  ? 20  LEU H CA  1 
ATOM   125  C C   . LEU A 1 24  ? 43.988 64.306  21.312  1.00 37.66  ? 20  LEU H C   1 
ATOM   126  O O   . LEU A 1 24  ? 43.924 63.727  22.396  1.00 38.34  ? 20  LEU H O   1 
ATOM   127  C CB  . LEU A 1 24  ? 43.400 66.735  21.335  1.00 37.10  ? 20  LEU H CB  1 
ATOM   128  C CG  . LEU A 1 24  ? 42.413 67.903  21.448  1.00 35.90  ? 20  LEU H CG  1 
ATOM   129  C CD1 . LEU A 1 24  ? 43.061 69.090  22.136  1.00 36.12  ? 20  LEU H CD1 1 
ATOM   130  C CD2 . LEU A 1 24  ? 41.887 68.323  20.097  1.00 36.93  ? 20  LEU H CD2 1 
ATOM   131  N N   . SER A 1 25  ? 44.960 64.104  20.426  1.00 38.39  ? 21  SER H N   1 
ATOM   132  C CA  . SER A 1 25  ? 45.964 63.056  20.598  1.00 36.72  ? 21  SER H CA  1 
ATOM   133  C C   . SER A 1 25  ? 47.362 63.590  20.466  1.00 36.94  ? 21  SER H C   1 
ATOM   134  O O   . SER A 1 25  ? 47.599 64.655  19.875  1.00 35.11  ? 21  SER H O   1 
ATOM   135  C CB  . SER A 1 25  ? 45.755 61.917  19.590  1.00 39.52  ? 21  SER H CB  1 
ATOM   136  O OG  . SER A 1 25  ? 46.020 62.313  18.250  1.00 39.17  ? 21  SER H OG  1 
ATOM   137  N N   . CYS A 1 26  ? 48.304 62.819  20.985  1.00 36.71  ? 22  CYS H N   1 
ATOM   138  C CA  . CYS A 1 26  ? 49.698 63.231  20.970  1.00 40.71  ? 22  CYS H CA  1 
ATOM   139  C C   . CYS A 1 26  ? 50.589 61.997  20.956  1.00 38.47  ? 22  CYS H C   1 
ATOM   140  O O   . CYS A 1 26  ? 50.716 61.293  21.955  1.00 31.02  ? 22  CYS H O   1 
ATOM   141  C CB  . CYS A 1 26  ? 49.964 64.134  22.168  1.00 45.70  ? 22  CYS H CB  1 
ATOM   142  S SG  . CYS A 1 26  ? 51.619 64.830  22.414  1.00 53.70  ? 22  CYS H SG  1 
ATOM   143  N N   . LYS A 1 27  ? 51.177 61.750  19.789  1.00 43.20  ? 23  LYS H N   1 
ATOM   144  C CA  . LYS A 1 27  ? 52.089 60.618  19.557  1.00 51.09  ? 23  LYS H CA  1 
ATOM   145  C C   . LYS A 1 27  ? 53.526 60.983  19.917  1.00 44.21  ? 23  LYS H C   1 
ATOM   146  O O   . LYS A 1 27  ? 54.063 61.940  19.399  1.00 37.24  ? 23  LYS H O   1 
ATOM   147  C CB  . LYS A 1 27  ? 52.030 60.168  18.081  1.00 57.84  ? 23  LYS H CB  1 
ATOM   148  C CG  . LYS A 1 27  ? 52.902 58.956  17.738  1.00 66.84  ? 23  LYS H CG  1 
ATOM   149  C CD  . LYS A 1 27  ? 52.834 58.600  16.260  1.00 73.66  ? 23  LYS H CD  1 
ATOM   150  C CE  . LYS A 1 27  ? 53.773 57.452  15.909  1.00 79.93  ? 23  LYS H CE  1 
ATOM   151  N NZ  . LYS A 1 27  ? 53.754 57.124  14.451  1.00 83.67  ? 23  LYS H NZ  1 
ATOM   152  N N   . THR A 1 28  ? 54.134 60.160  20.759  1.00 47.89  ? 24  THR H N   1 
ATOM   153  C CA  . THR A 1 28  ? 55.523 60.320  21.202  1.00 53.95  ? 24  THR H CA  1 
ATOM   154  C C   . THR A 1 28  ? 56.355 59.045  20.911  1.00 55.39  ? 24  THR H C   1 
ATOM   155  O O   . THR A 1 28  ? 55.873 58.131  20.257  1.00 59.59  ? 24  THR H O   1 
ATOM   156  C CB  . THR A 1 28  ? 55.568 60.596  22.717  1.00 54.62  ? 24  THR H CB  1 
ATOM   157  O OG1 . THR A 1 28  ? 55.559 59.353  23.419  1.00 56.42  ? 24  THR H OG1 1 
ATOM   158  C CG2 . THR A 1 28  ? 54.374 61.434  23.178  1.00 55.07  ? 24  THR H CG2 1 
ATOM   159  N N   . SER A 1 29  ? 57.601 59.000  21.388  1.00 56.70  ? 25  SER H N   1 
ATOM   160  C CA  . SER A 1 29  ? 58.430 57.787  21.296  1.00 56.33  ? 25  SER H CA  1 
ATOM   161  C C   . SER A 1 29  ? 58.121 56.822  22.451  1.00 57.12  ? 25  SER H C   1 
ATOM   162  O O   . SER A 1 29  ? 57.536 57.206  23.470  1.00 52.98  ? 25  SER H O   1 
ATOM   163  C CB  . SER A 1 29  ? 59.930 58.126  21.325  1.00 56.60  ? 25  SER H CB  1 
ATOM   164  O OG  . SER A 1 29  ? 60.327 59.022  20.285  1.00 59.77  ? 25  SER H OG  1 
ATOM   165  N N   . GLY A 1 30  ? 58.542 55.570  22.289  1.00 56.88  ? 26  GLY H N   1 
ATOM   166  C CA  . GLY A 1 30  ? 58.495 54.580  23.374  1.00 56.20  ? 26  GLY H CA  1 
ATOM   167  C C   . GLY A 1 30  ? 59.400 54.933  24.553  1.00 59.27  ? 26  GLY H C   1 
ATOM   168  O O   . GLY A 1 30  ? 59.135 54.541  25.692  1.00 53.67  ? 26  GLY H O   1 
ATOM   169  N N   . TYR A 1 31  ? 60.468 55.680  24.283  1.00 64.05  ? 27  TYR H N   1 
ATOM   170  C CA  . TYR A 1 31  ? 61.365 56.135  25.337  1.00 69.15  ? 27  TYR H CA  1 
ATOM   171  C C   . TYR A 1 31  ? 60.762 57.251  26.175  1.00 63.18  ? 27  TYR H C   1 
ATOM   172  O O   . TYR A 1 31  ? 60.779 57.197  27.408  1.00 60.45  ? 27  TYR H O   1 
ATOM   173  C CB  . TYR A 1 31  ? 62.685 56.613  24.746  1.00 73.16  ? 27  TYR H CB  1 
ATOM   174  C CG  . TYR A 1 31  ? 63.806 56.396  25.702  1.00 78.20  ? 27  TYR H CG  1 
ATOM   175  C CD1 . TYR A 1 31  ? 64.062 55.122  26.195  1.00 81.92  ? 27  TYR H CD1 1 
ATOM   176  C CD2 . TYR A 1 31  ? 64.605 57.452  26.141  1.00 81.01  ? 27  TYR H CD2 1 
ATOM   177  C CE1 . TYR A 1 31  ? 65.086 54.897  27.087  1.00 86.64  ? 27  TYR H CE1 1 
ATOM   178  C CE2 . TYR A 1 31  ? 65.647 57.232  27.033  1.00 85.35  ? 27  TYR H CE2 1 
ATOM   179  C CZ  . TYR A 1 31  ? 65.883 55.949  27.502  1.00 87.42  ? 27  TYR H CZ  1 
ATOM   180  O OH  . TYR A 1 31  ? 66.912 55.704  28.381  1.00 85.97  ? 27  TYR H OH  1 
ATOM   181  N N   . THR A 1 32  ? 60.243 58.257  25.478  1.00 60.31  ? 28  THR H N   1 
ATOM   182  C CA  . THR A 1 32  ? 59.499 59.360  26.079  1.00 60.15  ? 28  THR H CA  1 
ATOM   183  C C   . THR A 1 32  ? 58.464 58.875  27.079  1.00 60.61  ? 28  THR H C   1 
ATOM   184  O O   . THR A 1 32  ? 58.440 59.331  28.225  1.00 61.14  ? 28  THR H O   1 
ATOM   185  C CB  . THR A 1 32  ? 58.730 60.165  25.010  1.00 57.73  ? 28  THR H CB  1 
ATOM   186  O OG1 . THR A 1 32  ? 59.564 60.339  23.861  1.00 60.89  ? 28  THR H OG1 1 
ATOM   187  C CG2 . THR A 1 32  ? 58.267 61.545  25.563  1.00 53.64  ? 28  THR H CG2 1 
ATOM   188  N N   . PHE A 1 33  ? 57.616 57.957  26.623  1.00 55.21  ? 29  PHE H N   1 
ATOM   189  C CA  . PHE A 1 33  ? 56.452 57.518  27.394  1.00 55.71  ? 29  PHE H CA  1 
ATOM   190  C C   . PHE A 1 33  ? 56.863 56.892  28.713  1.00 58.12  ? 29  PHE H C   1 
ATOM   191  O O   . PHE A 1 33  ? 56.243 57.099  29.764  1.00 56.97  ? 29  PHE H O   1 
ATOM   192  C CB  . PHE A 1 33  ? 55.634 56.509  26.578  1.00 54.35  ? 29  PHE H CB  1 
ATOM   193  C CG  . PHE A 1 33  ? 54.184 56.868  26.460  1.00 49.72  ? 29  PHE H CG  1 
ATOM   194  C CD1 . PHE A 1 33  ? 53.805 58.123  25.966  1.00 45.60  ? 29  PHE H CD1 1 
ATOM   195  C CD2 . PHE A 1 33  ? 53.191 55.952  26.822  1.00 45.22  ? 29  PHE H CD2 1 
ATOM   196  C CE1 . PHE A 1 33  ? 52.465 58.450  25.856  1.00 44.63  ? 29  PHE H CE1 1 
ATOM   197  C CE2 . PHE A 1 33  ? 51.861 56.278  26.697  1.00 42.70  ? 29  PHE H CE2 1 
ATOM   198  C CZ  . PHE A 1 33  ? 51.496 57.521  26.216  1.00 43.04  ? 29  PHE H CZ  1 
ATOM   199  N N   . ASN A 1 34  ? 57.942 56.135  28.637  1.00 62.93  ? 30  ASN H N   1 
ATOM   200  C CA  . ASN A 1 34  ? 58.466 55.449  29.794  1.00 66.69  ? 30  ASN H CA  1 
ATOM   201  C C   . ASN A 1 34  ? 59.070 56.404  30.815  1.00 63.48  ? 30  ASN H C   1 
ATOM   202  O O   . ASN A 1 34  ? 58.853 56.243  32.009  1.00 63.65  ? 30  ASN H O   1 
ATOM   203  C CB  . ASN A 1 34  ? 59.496 54.401  29.351  1.00 70.15  ? 30  ASN H CB  1 
ATOM   204  C CG  . ASN A 1 34  ? 58.858 53.066  28.989  1.00 71.06  ? 30  ASN H CG  1 
ATOM   205  O OD1 . ASN A 1 34  ? 59.291 52.030  29.489  1.00 76.18  ? 30  ASN H OD1 1 
ATOM   206  N ND2 . ASN A 1 34  ? 57.825 53.077  28.129  1.00 67.01  ? 30  ASN H ND2 1 
ATOM   207  N N   . ASN A 1 35  ? 59.803 57.401  30.336  1.00 59.28  ? 31  ASN H N   1 
ATOM   208  C CA  . ASN A 1 35  ? 60.584 58.276  31.208  1.00 61.21  ? 31  ASN H CA  1 
ATOM   209  C C   . ASN A 1 35  ? 59.884 59.573  31.656  1.00 57.61  ? 31  ASN H C   1 
ATOM   210  O O   . ASN A 1 35  ? 59.912 59.919  32.839  1.00 62.06  ? 31  ASN H O   1 
ATOM   211  C CB  . ASN A 1 35  ? 61.917 58.604  30.515  1.00 63.06  ? 31  ASN H CB  1 
ATOM   212  C CG  . ASN A 1 35  ? 62.758 57.362  30.226  1.00 62.15  ? 31  ASN H CG  1 
ATOM   213  O OD1 . ASN A 1 35  ? 63.203 57.153  29.088  1.00 59.77  ? 31  ASN H OD1 1 
ATOM   214  N ND2 . ASN A 1 35  ? 62.987 56.534  31.253  1.00 58.55  ? 31  ASN H ND2 1 
ATOM   215  N N   . TYR A 1 36  ? 59.249 60.262  30.710  1.00 50.16  ? 32  TYR H N   1 
ATOM   216  C CA  . TYR A 1 36  ? 58.685 61.600  30.914  1.00 44.84  ? 32  TYR H CA  1 
ATOM   217  C C   . TYR A 1 36  ? 57.264 61.563  31.462  1.00 39.76  ? 32  TYR H C   1 
ATOM   218  O O   . TYR A 1 36  ? 56.519 60.632  31.206  1.00 34.53  ? 32  TYR H O   1 
ATOM   219  C CB  . TYR A 1 36  ? 58.626 62.349  29.575  1.00 48.41  ? 32  TYR H CB  1 
ATOM   220  C CG  . TYR A 1 36  ? 59.961 62.780  29.002  1.00 52.47  ? 32  TYR H CG  1 
ATOM   221  C CD1 . TYR A 1 36  ? 60.983 61.860  28.743  1.00 53.91  ? 32  TYR H CD1 1 
ATOM   222  C CD2 . TYR A 1 36  ? 60.199 64.126  28.694  1.00 58.51  ? 32  TYR H CD2 1 
ATOM   223  C CE1 . TYR A 1 36  ? 62.200 62.273  28.218  1.00 56.63  ? 32  TYR H CE1 1 
ATOM   224  C CE2 . TYR A 1 36  ? 61.412 64.551  28.166  1.00 57.04  ? 32  TYR H CE2 1 
ATOM   225  C CZ  . TYR A 1 36  ? 62.404 63.624  27.927  1.00 59.04  ? 32  TYR H CZ  1 
ATOM   226  O OH  . TYR A 1 36  ? 63.586 64.057  27.399  1.00 62.21  ? 32  TYR H OH  1 
ATOM   227  N N   . TRP A 1 37  ? 56.875 62.616  32.177  1.00 38.78  ? 33  TRP H N   1 
ATOM   228  C CA  . TRP A 1 37  ? 55.460 62.890  32.420  1.00 37.64  ? 33  TRP H CA  1 
ATOM   229  C C   . TRP A 1 37  ? 54.914 63.671  31.258  1.00 40.06  ? 33  TRP H C   1 
ATOM   230  O O   . TRP A 1 37  ? 55.675 64.353  30.549  1.00 39.79  ? 33  TRP H O   1 
ATOM   231  C CB  . TRP A 1 37  ? 55.218 63.764  33.638  1.00 37.80  ? 33  TRP H CB  1 
ATOM   232  C CG  . TRP A 1 37  ? 55.391 63.137  34.930  1.00 35.94  ? 33  TRP H CG  1 
ATOM   233  C CD1 . TRP A 1 37  ? 56.552 62.634  35.453  1.00 36.57  ? 33  TRP H CD1 1 
ATOM   234  C CD2 . TRP A 1 37  ? 54.404 63.015  35.944  1.00 35.66  ? 33  TRP H CD2 1 
ATOM   235  N NE1 . TRP A 1 37  ? 56.342 62.188  36.732  1.00 33.63  ? 33  TRP H NE1 1 
ATOM   236  C CE2 . TRP A 1 37  ? 55.028 62.399  37.057  1.00 36.56  ? 33  TRP H CE2 1 
ATOM   237  C CE3 . TRP A 1 37  ? 53.039 63.338  36.018  1.00 35.86  ? 33  TRP H CE3 1 
ATOM   238  C CZ2 . TRP A 1 37  ? 54.333 62.103  38.233  1.00 37.08  ? 33  TRP H CZ2 1 
ATOM   239  C CZ3 . TRP A 1 37  ? 52.345 63.048  37.184  1.00 36.81  ? 33  TRP H CZ3 1 
ATOM   240  C CH2 . TRP A 1 37  ? 52.994 62.438  38.283  1.00 37.21  ? 33  TRP H CH2 1 
ATOM   241  N N   . ILE A 1 38  ? 53.577 63.614  31.131  1.00 39.39  ? 34  ILE H N   1 
ATOM   242  C CA  . ILE A 1 38  ? 52.831 64.277  30.069  1.00 37.65  ? 34  ILE H CA  1 
ATOM   243  C C   . ILE A 1 38  ? 51.908 65.298  30.699  1.00 36.36  ? 34  ILE H C   1 
ATOM   244  O O   . ILE A 1 38  ? 51.246 65.006  31.692  1.00 38.32  ? 34  ILE H O   1 
ATOM   245  C CB  . ILE A 1 38  ? 51.993 63.285  29.232  1.00 40.30  ? 34  ILE H CB  1 
ATOM   246  C CG1 . ILE A 1 38  ? 52.888 62.232  28.553  1.00 40.06  ? 34  ILE H CG1 1 
ATOM   247  C CG2 . ILE A 1 38  ? 51.137 64.026  28.205  1.00 41.88  ? 34  ILE H CG2 1 
ATOM   248  C CD1 . ILE A 1 38  ? 53.628 62.681  27.306  1.00 41.69  ? 34  ILE H CD1 1 
ATOM   249  N N   . HIS A 1 39  ? 51.872 66.489  30.095  1.00 35.00  ? 35  HIS H N   1 
ATOM   250  C CA  . HIS A 1 39  ? 51.064 67.628  30.539  1.00 32.07  ? 35  HIS H CA  1 
ATOM   251  C C   . HIS A 1 39  ? 50.287 68.134  29.371  1.00 31.41  ? 35  HIS H C   1 
ATOM   252  O O   . HIS A 1 39  ? 50.686 67.953  28.223  1.00 32.94  ? 35  HIS H O   1 
ATOM   253  C CB  . HIS A 1 39  ? 51.938 68.789  31.027  1.00 32.60  ? 35  HIS H CB  1 
ATOM   254  C CG  . HIS A 1 39  ? 52.802 68.432  32.187  1.00 33.80  ? 35  HIS H CG  1 
ATOM   255  N ND1 . HIS A 1 39  ? 52.417 68.661  33.488  1.00 34.44  ? 35  HIS H ND1 1 
ATOM   256  C CD2 . HIS A 1 39  ? 53.997 67.807  32.251  1.00 32.55  ? 35  HIS H CD2 1 
ATOM   257  C CE1 . HIS A 1 39  ? 53.356 68.229  34.303  1.00 34.11  ? 35  HIS H CE1 1 
ATOM   258  N NE2 . HIS A 1 39  ? 54.320 67.696  33.578  1.00 32.77  ? 35  HIS H NE2 1 
ATOM   259  N N   . TRP A 1 40  ? 49.186 68.804  29.666  1.00 28.90  ? 36  TRP H N   1 
ATOM   260  C CA  . TRP A 1 40  ? 48.424 69.457  28.638  1.00 27.97  ? 36  TRP H CA  1 
ATOM   261  C C   . TRP A 1 40  ? 48.305 70.912  29.019  1.00 27.60  ? 36  TRP H C   1 
ATOM   262  O O   . TRP A 1 40  ? 48.198 71.247  30.213  1.00 30.41  ? 36  TRP H O   1 
ATOM   263  C CB  . TRP A 1 40  ? 47.056 68.777  28.478  1.00 27.86  ? 36  TRP H CB  1 
ATOM   264  C CG  . TRP A 1 40  ? 47.125 67.474  27.740  1.00 25.47  ? 36  TRP H CG  1 
ATOM   265  C CD1 . TRP A 1 40  ? 47.342 66.236  28.278  1.00 27.33  ? 36  TRP H CD1 1 
ATOM   266  C CD2 . TRP A 1 40  ? 46.994 67.287  26.346  1.00 24.94  ? 36  TRP H CD2 1 
ATOM   267  N NE1 . TRP A 1 40  ? 47.333 65.279  27.306  1.00 26.81  ? 36  TRP H NE1 1 
ATOM   268  C CE2 . TRP A 1 40  ? 47.122 65.893  26.098  1.00 26.48  ? 36  TRP H CE2 1 
ATOM   269  C CE3 . TRP A 1 40  ? 46.772 68.156  25.268  1.00 25.40  ? 36  TRP H CE3 1 
ATOM   270  C CZ2 . TRP A 1 40  ? 47.031 65.340  24.813  1.00 25.69  ? 36  TRP H CZ2 1 
ATOM   271  C CZ3 . TRP A 1 40  ? 46.684 67.604  23.973  1.00 26.30  ? 36  TRP H CZ3 1 
ATOM   272  C CH2 . TRP A 1 40  ? 46.821 66.206  23.766  1.00 26.18  ? 36  TRP H CH2 1 
ATOM   273  N N   . VAL A 1 41  ? 48.361 71.780  28.016  1.00 26.40  ? 37  VAL H N   1 
ATOM   274  C CA  . VAL A 1 41  ? 48.377 73.224  28.251  1.00 26.88  ? 37  VAL H CA  1 
ATOM   275  C C   . VAL A 1 41  ? 47.503 73.890  27.220  1.00 26.53  ? 37  VAL H C   1 
ATOM   276  O O   . VAL A 1 41  ? 47.502 73.495  26.061  1.00 25.85  ? 37  VAL H O   1 
ATOM   277  C CB  . VAL A 1 41  ? 49.808 73.821  28.195  1.00 27.69  ? 37  VAL H CB  1 
ATOM   278  C CG1 . VAL A 1 41  ? 49.798 75.339  28.304  1.00 28.08  ? 37  VAL H CG1 1 
ATOM   279  C CG2 . VAL A 1 41  ? 50.665 73.292  29.328  1.00 28.98  ? 37  VAL H CG2 1 
ATOM   280  N N   . LYS A 1 42  ? 46.797 74.926  27.659  1.00 28.55  ? 38  LYS H N   1 
ATOM   281  C CA  . LYS A 1 42  ? 45.897 75.699  26.817  1.00 31.55  ? 38  LYS H CA  1 
ATOM   282  C C   . LYS A 1 42  ? 46.382 77.128  26.596  1.00 33.93  ? 38  LYS H C   1 
ATOM   283  O O   . LYS A 1 42  ? 46.731 77.828  27.567  1.00 33.27  ? 38  LYS H O   1 
ATOM   284  C CB  . LYS A 1 42  ? 44.535 75.779  27.480  1.00 33.28  ? 38  LYS H CB  1 
ATOM   285  C CG  . LYS A 1 42  ? 43.465 76.426  26.608  1.00 36.43  ? 38  LYS H CG  1 
ATOM   286  C CD  . LYS A 1 42  ? 42.149 76.492  27.353  1.00 38.34  ? 38  LYS H CD  1 
ATOM   287  C CE  . LYS A 1 42  ? 41.194 77.485  26.725  1.00 38.51  ? 38  LYS H CE  1 
ATOM   288  N NZ  . LYS A 1 42  ? 39.952 77.497  27.530  1.00 39.75  ? 38  LYS H NZ  1 
ATOM   289  N N   . GLN A 1 43  ? 46.341 77.561  25.327  1.00 33.98  ? 39  GLN H N   1 
ATOM   290  C CA  . GLN A 1 43  ? 46.631 78.958  24.939  1.00 33.09  ? 39  GLN H CA  1 
ATOM   291  C C   . GLN A 1 43  ? 45.482 79.522  24.156  1.00 33.34  ? 39  GLN H C   1 
ATOM   292  O O   . GLN A 1 43  ? 45.166 79.022  23.067  1.00 34.07  ? 39  GLN H O   1 
ATOM   293  C CB  . GLN A 1 43  ? 47.909 79.087  24.097  1.00 32.42  ? 39  GLN H CB  1 
ATOM   294  C CG  . GLN A 1 43  ? 48.421 80.517  23.961  1.00 29.62  ? 39  GLN H CG  1 
ATOM   295  C CD  . GLN A 1 43  ? 49.870 80.569  23.552  1.00 28.67  ? 39  GLN H CD  1 
ATOM   296  O OE1 . GLN A 1 43  ? 50.326 79.735  22.785  1.00 29.99  ? 39  GLN H OE1 1 
ATOM   297  N NE2 . GLN A 1 43  ? 50.607 81.552  24.059  1.00 28.69  ? 39  GLN H NE2 1 
ATOM   298  N N   . SER A 1 44  ? 44.898 80.577  24.711  1.00 33.40  ? 40  SER H N   1 
ATOM   299  C CA  . SER A 1 44  ? 43.698 81.214  24.198  1.00 36.24  ? 40  SER H CA  1 
ATOM   300  C C   . SER A 1 44  ? 43.856 82.711  24.341  1.00 38.44  ? 40  SER H C   1 
ATOM   301  O O   . SER A 1 44  ? 44.543 83.173  25.274  1.00 35.76  ? 40  SER H O   1 
ATOM   302  C CB  . SER A 1 44  ? 42.459 80.784  24.981  1.00 34.11  ? 40  SER H CB  1 
ATOM   303  O OG  . SER A 1 44  ? 42.299 81.528  26.177  1.00 33.73  ? 40  SER H OG  1 
ATOM   304  N N   . PRO A 1 45  ? 43.215 83.473  23.438  1.00 43.05  ? 41  PRO H N   1 
ATOM   305  C CA  . PRO A 1 45  ? 43.451 84.923  23.437  1.00 45.33  ? 41  PRO H CA  1 
ATOM   306  C C   . PRO A 1 45  ? 42.772 85.593  24.622  1.00 48.13  ? 41  PRO H C   1 
ATOM   307  O O   . PRO A 1 45  ? 43.256 86.608  25.117  1.00 48.49  ? 41  PRO H O   1 
ATOM   308  C CB  . PRO A 1 45  ? 42.845 85.400  22.101  1.00 46.12  ? 41  PRO H CB  1 
ATOM   309  C CG  . PRO A 1 45  ? 42.101 84.228  21.515  1.00 44.52  ? 41  PRO H CG  1 
ATOM   310  C CD  . PRO A 1 45  ? 42.193 83.059  22.447  1.00 44.06  ? 41  PRO H CD  1 
ATOM   311  N N   . GLY A 1 46  ? 41.665 85.013  25.079  1.00 49.70  ? 42  GLY H N   1 
ATOM   312  C CA  . GLY A 1 46  ? 40.976 85.491  26.264  1.00 50.42  ? 42  GLY H CA  1 
ATOM   313  C C   . GLY A 1 46  ? 41.779 85.217  27.521  1.00 49.80  ? 42  GLY H C   1 
ATOM   314  O O   . GLY A 1 46  ? 42.059 86.141  28.288  1.00 50.31  ? 42  GLY H O   1 
ATOM   315  N N   . GLN A 1 47  ? 42.179 83.960  27.720  1.00 46.44  ? 43  GLN H N   1 
ATOM   316  C CA  . GLN A 1 47  ? 42.802 83.568  28.994  1.00 43.13  ? 43  GLN H CA  1 
ATOM   317  C C   . GLN A 1 47  ? 44.299 83.268  29.018  1.00 38.94  ? 43  GLN H C   1 
ATOM   318  O O   . GLN A 1 47  ? 44.813 82.907  30.070  1.00 30.62  ? 43  GLN H O   1 
ATOM   319  C CB  . GLN A 1 47  ? 41.986 82.461  29.624  1.00 48.50  ? 43  GLN H CB  1 
ATOM   320  C CG  . GLN A 1 47  ? 40.653 83.022  30.090  1.00 55.71  ? 43  GLN H CG  1 
ATOM   321  C CD  . GLN A 1 47  ? 39.930 82.115  31.059  1.00 66.43  ? 43  GLN H CD  1 
ATOM   322  O OE1 . GLN A 1 47  ? 40.221 82.121  32.262  1.00 74.02  ? 43  GLN H OE1 1 
ATOM   323  N NE2 . GLN A 1 47  ? 38.964 81.342  30.550  1.00 68.86  ? 43  GLN H NE2 1 
ATOM   324  N N   . GLY A 1 48  ? 45.011 83.484  27.906  1.00 35.07  ? 44  GLY H N   1 
ATOM   325  C CA  . GLY A 1 48  ? 46.464 83.271  27.891  1.00 33.24  ? 44  GLY H CA  1 
ATOM   326  C C   . GLY A 1 48  ? 46.798 81.794  28.086  1.00 32.00  ? 44  GLY H C   1 
ATOM   327  O O   . GLY A 1 48  ? 46.028 80.920  27.674  1.00 31.75  ? 44  GLY H O   1 
ATOM   328  N N   . LEU A 1 49  ? 47.922 81.532  28.749  1.00 27.96  ? 45  LEU H N   1 
ATOM   329  C CA  . LEU A 1 49  ? 48.408 80.188  28.957  1.00 26.87  ? 45  LEU H CA  1 
ATOM   330  C C   . LEU A 1 49  ? 47.892 79.607  30.276  1.00 26.70  ? 45  LEU H C   1 
ATOM   331  O O   . LEU A 1 49  ? 48.022 80.235  31.357  1.00 25.46  ? 45  LEU H O   1 
ATOM   332  C CB  . LEU A 1 49  ? 49.944 80.148  28.928  1.00 25.63  ? 45  LEU H CB  1 
ATOM   333  C CG  . LEU A 1 49  ? 50.618 80.146  27.552  1.00 25.35  ? 45  LEU H CG  1 
ATOM   334  C CD1 . LEU A 1 49  ? 52.102 80.357  27.731  1.00 25.97  ? 45  LEU H CD1 1 
ATOM   335  C CD2 . LEU A 1 49  ? 50.412 78.877  26.725  1.00 25.51  ? 45  LEU H CD2 1 
ATOM   336  N N   . GLU A 1 50  ? 47.355 78.393  30.169  1.00 24.84  ? 46  GLU H N   1 
ATOM   337  C CA  . GLU A 1 50  ? 46.768 77.693  31.284  1.00 25.89  ? 46  GLU H CA  1 
ATOM   338  C C   . GLU A 1 50  ? 47.158 76.234  31.323  1.00 24.92  ? 46  GLU H C   1 
ATOM   339  O O   . GLU A 1 50  ? 47.118 75.557  30.304  1.00 24.32  ? 46  GLU H O   1 
ATOM   340  C CB  . GLU A 1 50  ? 45.233 77.771  31.207  1.00 29.49  ? 46  GLU H CB  1 
ATOM   341  C CG  . GLU A 1 50  ? 44.651 79.152  31.481  1.00 29.67  ? 46  GLU H CG  1 
ATOM   342  C CD  . GLU A 1 50  ? 43.143 79.172  31.373  1.00 30.90  ? 46  GLU H CD  1 
ATOM   343  O OE1 . GLU A 1 50  ? 42.596 79.082  30.260  1.00 31.93  ? 46  GLU H OE1 1 
ATOM   344  O OE2 . GLU A 1 50  ? 42.505 79.282  32.427  1.00 36.27  ? 46  GLU H OE2 1 
ATOM   345  N N   . TRP A 1 51  ? 47.496 75.757  32.515  1.00 24.47  ? 47  TRP H N   1 
ATOM   346  C CA  . TRP A 1 51  ? 47.763 74.336  32.747  1.00 26.95  ? 47  TRP H CA  1 
ATOM   347  C C   . TRP A 1 51  ? 46.452 73.579  32.958  1.00 26.65  ? 47  TRP H C   1 
ATOM   348  O O   . TRP A 1 51  ? 45.661 73.917  33.820  1.00 25.85  ? 47  TRP H O   1 
ATOM   349  C CB  . TRP A 1 51  ? 48.683 74.169  33.958  1.00 28.09  ? 47  TRP H CB  1 
ATOM   350  C CG  . TRP A 1 51  ? 48.983 72.744  34.356  1.00 30.50  ? 47  TRP H CG  1 
ATOM   351  C CD1 . TRP A 1 51  ? 49.791 71.863  33.709  1.00 31.17  ? 47  TRP H CD1 1 
ATOM   352  C CD2 . TRP A 1 51  ? 48.505 72.064  35.530  1.00 32.96  ? 47  TRP H CD2 1 
ATOM   353  N NE1 . TRP A 1 51  ? 49.814 70.662  34.384  1.00 33.33  ? 47  TRP H NE1 1 
ATOM   354  C CE2 . TRP A 1 51  ? 49.041 70.762  35.507  1.00 33.42  ? 47  TRP H CE2 1 
ATOM   355  C CE3 . TRP A 1 51  ? 47.642 72.417  36.572  1.00 35.05  ? 47  TRP H CE3 1 
ATOM   356  C CZ2 . TRP A 1 51  ? 48.778 69.825  36.510  1.00 35.20  ? 47  TRP H CZ2 1 
ATOM   357  C CZ3 . TRP A 1 51  ? 47.367 71.479  37.568  1.00 34.65  ? 47  TRP H CZ3 1 
ATOM   358  C CH2 . TRP A 1 51  ? 47.927 70.197  37.521  1.00 34.80  ? 47  TRP H CH2 1 
ATOM   359  N N   . ILE A 1 52  ? 46.226 72.546  32.163  1.00 28.53  ? 48  ILE H N   1 
ATOM   360  C CA  . ILE A 1 52  ? 44.976 71.802  32.231  1.00 29.63  ? 48  ILE H CA  1 
ATOM   361  C C   . ILE A 1 52  ? 45.143 70.712  33.280  1.00 31.15  ? 48  ILE H C   1 
ATOM   362  O O   . ILE A 1 52  ? 44.273 70.533  34.139  1.00 31.86  ? 48  ILE H O   1 
ATOM   363  C CB  . ILE A 1 52  ? 44.596 71.204  30.846  1.00 30.26  ? 48  ILE H CB  1 
ATOM   364  C CG1 . ILE A 1 52  ? 44.124 72.318  29.895  1.00 31.05  ? 48  ILE H CG1 1 
ATOM   365  C CG2 . ILE A 1 52  ? 43.489 70.170  30.977  1.00 29.67  ? 48  ILE H CG2 1 
ATOM   366  C CD1 . ILE A 1 52  ? 44.235 71.959  28.434  1.00 31.78  ? 48  ILE H CD1 1 
ATOM   367  N N   . GLY A 1 53  ? 46.239 69.965  33.159  1.00 31.07  ? 49  GLY H N   1 
ATOM   368  C CA  . GLY A 1 53  ? 46.504 68.817  33.994  1.00 32.59  ? 49  GLY H CA  1 
ATOM   369  C C   . GLY A 1 53  ? 47.686 68.016  33.492  1.00 36.16  ? 49  GLY H C   1 
ATOM   370  O O   . GLY A 1 53  ? 48.282 68.336  32.461  1.00 38.39  ? 49  GLY H O   1 
ATOM   371  N N   . GLU A 1 54  ? 47.999 66.961  34.247  1.00 36.53  ? 50  GLU H N   1 
ATOM   372  C CA  . GLU A 1 54  ? 49.162 66.100  34.037  1.00 34.18  ? 50  GLU H CA  1 
ATOM   373  C C   . GLU A 1 54  ? 48.784 64.626  34.243  1.00 34.26  ? 50  GLU H C   1 
ATOM   374  O O   . GLU A 1 54  ? 47.831 64.316  34.945  1.00 39.60  ? 50  GLU H O   1 
ATOM   375  C CB  . GLU A 1 54  ? 50.286 66.505  35.011  1.00 33.98  ? 50  GLU H CB  1 
ATOM   376  C CG  . GLU A 1 54  ? 49.922 66.253  36.475  1.00 34.29  ? 50  GLU H CG  1 
ATOM   377  C CD  . GLU A 1 54  ? 50.946 66.750  37.461  1.00 31.38  ? 50  GLU H CD  1 
ATOM   378  O OE1 . GLU A 1 54  ? 51.033 66.164  38.557  1.00 29.21  ? 50  GLU H OE1 1 
ATOM   379  O OE2 . GLU A 1 54  ? 51.643 67.717  37.150  1.00 29.47  ? 50  GLU H OE2 1 
ATOM   380  N N   . ILE A 1 55  ? 49.533 63.734  33.613  1.00 35.19  ? 51  ILE H N   1 
ATOM   381  C CA  . ILE A 1 55  ? 49.361 62.287  33.749  1.00 36.20  ? 51  ILE H CA  1 
ATOM   382  C C   . ILE A 1 55  ? 50.724 61.598  33.624  1.00 37.49  ? 51  ILE H C   1 
ATOM   383  O O   . ILE A 1 55  ? 51.524 61.903  32.736  1.00 36.34  ? 51  ILE H O   1 
ATOM   384  C CB  . ILE A 1 55  ? 48.387 61.695  32.701  1.00 37.37  ? 51  ILE H CB  1 
ATOM   385  C CG1 . ILE A 1 55  ? 48.214 60.184  32.929  1.00 38.36  ? 51  ILE H CG1 1 
ATOM   386  C CG2 . ILE A 1 55  ? 48.836 62.026  31.265  1.00 37.74  ? 51  ILE H CG2 1 
ATOM   387  C CD1 . ILE A 1 55  ? 47.194 59.532  32.024  1.00 39.60  ? 51  ILE H CD1 1 
ATOM   388  N N   . ASP A 1 56  ? 50.962 60.651  34.515  1.00 40.24  ? 52  ASP H N   1 
ATOM   389  C CA  . ASP A 1 56  ? 52.185 59.867  34.523  1.00 41.18  ? 52  ASP H CA  1 
ATOM   390  C C   . ASP A 1 56  ? 51.922 58.612  33.674  1.00 43.40  ? 52  ASP H C   1 
ATOM   391  O O   . ASP A 1 56  ? 51.281 57.678  34.146  1.00 44.06  ? 52  ASP H O   1 
ATOM   392  C CB  . ASP A 1 56  ? 52.526 59.489  35.957  1.00 40.00  ? 52  ASP H CB  1 
ATOM   393  C CG  . ASP A 1 56  ? 53.871 58.829  36.083  1.00 44.49  ? 52  ASP H CG  1 
ATOM   394  O OD1 . ASP A 1 56  ? 54.525 58.500  35.054  1.00 47.83  ? 52  ASP H OD1 1 
ATOM   395  O OD2 . ASP A 1 56  ? 54.278 58.645  37.242  1.00 42.94  ? 52  ASP H OD2 1 
ATOM   396  N N   . PRO A 1 57  A 52.419 58.574  32.424  1.00 43.10  ? 52  PRO H N   1 
ATOM   397  C CA  . PRO A 1 57  A 52.097 57.425  31.580  1.00 42.25  ? 52  PRO H CA  1 
ATOM   398  C C   . PRO A 1 57  A 52.513 56.086  32.162  1.00 40.59  ? 52  PRO H C   1 
ATOM   399  O O   . PRO A 1 57  A 51.933 55.078  31.804  1.00 40.98  ? 52  PRO H O   1 
ATOM   400  C CB  . PRO A 1 57  A 52.887 57.679  30.291  1.00 45.17  ? 52  PRO H CB  1 
ATOM   401  C CG  . PRO A 1 57  A 53.399 59.072  30.384  1.00 45.72  ? 52  PRO H CG  1 
ATOM   402  C CD  . PRO A 1 57  A 53.471 59.407  31.832  1.00 44.47  ? 52  PRO H CD  1 
ATOM   403  N N   . SER A 1 58  ? 53.509 56.066  33.041  1.00 43.70  ? 53  SER H N   1 
ATOM   404  C CA  . SER A 1 58  ? 53.936 54.802  33.640  1.00 45.72  ? 53  SER H CA  1 
ATOM   405  C C   . SER A 1 58  ? 52.743 54.046  34.269  1.00 48.65  ? 53  SER H C   1 
ATOM   406  O O   . SER A 1 58  ? 52.554 52.859  33.989  1.00 50.18  ? 53  SER H O   1 
ATOM   407  C CB  . SER A 1 58  ? 55.100 54.999  34.631  1.00 43.90  ? 53  SER H CB  1 
ATOM   408  O OG  . SER A 1 58  ? 54.758 55.772  35.774  1.00 43.14  ? 53  SER H OG  1 
ATOM   409  N N   . ASP A 1 59  ? 51.919 54.745  35.054  1.00 47.37  ? 54  ASP H N   1 
ATOM   410  C CA  . ASP A 1 59  ? 50.801 54.107  35.778  1.00 49.58  ? 54  ASP H CA  1 
ATOM   411  C C   . ASP A 1 59  ? 49.435 54.751  35.568  1.00 49.38  ? 54  ASP H C   1 
ATOM   412  O O   . ASP A 1 59  ? 48.485 54.406  36.254  1.00 49.79  ? 54  ASP H O   1 
ATOM   413  C CB  . ASP A 1 59  ? 51.111 54.050  37.278  1.00 52.99  ? 54  ASP H CB  1 
ATOM   414  C CG  . ASP A 1 59  ? 51.405 55.423  37.879  1.00 55.67  ? 54  ASP H CG  1 
ATOM   415  O OD1 . ASP A 1 59  ? 51.535 56.409  37.120  1.00 55.43  ? 54  ASP H OD1 1 
ATOM   416  O OD2 . ASP A 1 59  ? 51.530 55.507  39.116  1.00 56.89  ? 54  ASP H OD2 1 
ATOM   417  N N   . GLY A 1 60  ? 49.341 55.699  34.641  1.00 49.48  ? 55  GLY H N   1 
ATOM   418  C CA  . GLY A 1 60  ? 48.090 56.427  34.383  1.00 49.48  ? 55  GLY H CA  1 
ATOM   419  C C   . GLY A 1 60  ? 47.568 57.380  35.451  1.00 45.75  ? 55  GLY H C   1 
ATOM   420  O O   . GLY A 1 60  ? 46.458 57.894  35.310  1.00 41.94  ? 55  GLY H O   1 
ATOM   421  N N   . TYR A 1 61  ? 48.351 57.615  36.501  1.00 41.83  ? 56  TYR H N   1 
ATOM   422  C CA  . TYR A 1 61  ? 47.975 58.536  37.567  1.00 47.00  ? 56  TYR H CA  1 
ATOM   423  C C   . TYR A 1 61  ? 47.972 59.977  37.050  1.00 41.63  ? 56  TYR H C   1 
ATOM   424  O O   . TYR A 1 61  ? 48.867 60.379  36.320  1.00 43.37  ? 56  TYR H O   1 
ATOM   425  C CB  . TYR A 1 61  ? 48.946 58.398  38.740  1.00 51.76  ? 56  TYR H CB  1 
ATOM   426  C CG  . TYR A 1 61  ? 48.649 59.328  39.890  1.00 58.78  ? 56  TYR H CG  1 
ATOM   427  C CD1 . TYR A 1 61  ? 49.135 60.634  39.894  1.00 59.02  ? 56  TYR H CD1 1 
ATOM   428  C CD2 . TYR A 1 61  ? 47.890 58.901  40.979  1.00 65.45  ? 56  TYR H CD2 1 
ATOM   429  C CE1 . TYR A 1 61  ? 48.863 61.485  40.934  1.00 61.89  ? 56  TYR H CE1 1 
ATOM   430  C CE2 . TYR A 1 61  ? 47.620 59.755  42.035  1.00 68.68  ? 56  TYR H CE2 1 
ATOM   431  C CZ  . TYR A 1 61  ? 48.106 61.049  42.000  1.00 66.37  ? 56  TYR H CZ  1 
ATOM   432  O OH  . TYR A 1 61  ? 47.855 61.912  43.036  1.00 70.57  ? 56  TYR H OH  1 
ATOM   433  N N   . SER A 1 62  ? 46.985 60.754  37.462  1.00 39.98  ? 57  SER H N   1 
ATOM   434  C CA  . SER A 1 62  ? 46.736 62.062  36.852  1.00 42.09  ? 57  SER H CA  1 
ATOM   435  C C   . SER A 1 62  ? 46.256 63.065  37.869  1.00 40.67  ? 57  SER H C   1 
ATOM   436  O O   . SER A 1 62  ? 45.505 62.695  38.759  1.00 42.10  ? 57  SER H O   1 
ATOM   437  C CB  . SER A 1 62  ? 45.665 61.938  35.778  1.00 40.82  ? 57  SER H CB  1 
ATOM   438  O OG  . SER A 1 62  ? 44.409 61.747  36.378  1.00 40.41  ? 57  SER H OG  1 
ATOM   439  N N   . ASN A 1 63  ? 46.684 64.322  37.720  1.00 40.99  ? 58  ASN H N   1 
ATOM   440  C CA  . ASN A 1 63  ? 46.150 65.454  38.498  1.00 41.84  ? 58  ASN H CA  1 
ATOM   441  C C   . ASN A 1 63  ? 45.675 66.552  37.566  1.00 40.37  ? 58  ASN H C   1 
ATOM   442  O O   . ASN A 1 63  ? 46.168 66.705  36.424  1.00 41.98  ? 58  ASN H O   1 
ATOM   443  C CB  . ASN A 1 63  ? 47.177 66.045  39.459  1.00 46.26  ? 58  ASN H CB  1 
ATOM   444  C CG  . ASN A 1 63  ? 47.939 64.989  40.243  1.00 53.32  ? 58  ASN H CG  1 
ATOM   445  O OD1 . ASN A 1 63  ? 47.419 64.410  41.196  1.00 58.40  ? 58  ASN H OD1 1 
ATOM   446  N ND2 . ASN A 1 63  ? 49.195 64.756  39.863  1.00 57.58  ? 58  ASN H ND2 1 
ATOM   447  N N   . TYR A 1 64  ? 44.735 67.338  38.072  1.00 37.77  ? 59  TYR H N   1 
ATOM   448  C CA  . TYR A 1 64  ? 44.038 68.324  37.268  1.00 35.85  ? 59  TYR H CA  1 
ATOM   449  C C   . TYR A 1 64  ? 43.955 69.678  37.921  1.00 35.39  ? 59  TYR H C   1 
ATOM   450  O O   . TYR A 1 64  ? 43.771 69.812  39.139  1.00 32.41  ? 59  TYR H O   1 
ATOM   451  C CB  . TYR A 1 64  ? 42.600 67.886  36.974  1.00 35.62  ? 59  TYR H CB  1 
ATOM   452  C CG  . TYR A 1 64  ? 42.511 66.656  36.146  1.00 35.39  ? 59  TYR H CG  1 
ATOM   453  C CD1 . TYR A 1 64  ? 42.591 65.393  36.736  1.00 34.89  ? 59  TYR H CD1 1 
ATOM   454  C CD2 . TYR A 1 64  ? 42.337 66.744  34.768  1.00 37.80  ? 59  TYR H CD2 1 
ATOM   455  C CE1 . TYR A 1 64  ? 42.491 64.252  35.978  1.00 35.66  ? 59  TYR H CE1 1 
ATOM   456  C CE2 . TYR A 1 64  ? 42.254 65.606  33.984  1.00 38.78  ? 59  TYR H CE2 1 
ATOM   457  C CZ  . TYR A 1 64  ? 42.315 64.364  34.592  1.00 38.80  ? 59  TYR H CZ  1 
ATOM   458  O OH  . TYR A 1 64  ? 42.209 63.253  33.799  1.00 39.32  ? 59  TYR H OH  1 
ATOM   459  N N   . ASN A 1 65  ? 44.040 70.683  37.058  1.00 33.89  ? 60  ASN H N   1 
ATOM   460  C CA  . ASN A 1 65  ? 43.629 71.993  37.398  1.00 34.62  ? 60  ASN H CA  1 
ATOM   461  C C   . ASN A 1 65  ? 42.146 71.894  37.734  1.00 38.88  ? 60  ASN H C   1 
ATOM   462  O O   . ASN A 1 65  ? 41.324 71.585  36.875  1.00 35.39  ? 60  ASN H O   1 
ATOM   463  C CB  . ASN A 1 65  ? 43.868 72.931  36.210  1.00 36.09  ? 60  ASN H CB  1 
ATOM   464  C CG  . ASN A 1 65  ? 43.572 74.402  36.535  1.00 34.74  ? 60  ASN H CG  1 
ATOM   465  O OD1 . ASN A 1 65  ? 42.847 74.700  37.462  1.00 36.43  ? 60  ASN H OD1 1 
ATOM   466  N ND2 . ASN A 1 65  ? 44.124 75.309  35.757  1.00 33.18  ? 60  ASN H ND2 1 
ATOM   467  N N   . GLN A 1 66  ? 41.824 72.150  38.996  1.00 42.22  ? 61  GLN H N   1 
ATOM   468  C CA  . GLN A 1 66  ? 40.440 72.249  39.486  1.00 44.25  ? 61  GLN H CA  1 
ATOM   469  C C   . GLN A 1 66  ? 39.475 72.806  38.455  1.00 40.52  ? 61  GLN H C   1 
ATOM   470  O O   . GLN A 1 66  ? 38.383 72.301  38.280  1.00 37.30  ? 61  GLN H O   1 
ATOM   471  C CB  . GLN A 1 66  ? 40.389 73.165  40.732  1.00 49.57  ? 61  GLN H CB  1 
ATOM   472  C CG  . GLN A 1 66  ? 39.077 73.149  41.519  1.00 54.89  ? 61  GLN H CG  1 
ATOM   473  C CD  . GLN A 1 66  ? 38.586 71.747  41.881  1.00 61.19  ? 61  GLN H CD  1 
ATOM   474  O OE1 . GLN A 1 66  ? 37.434 71.413  41.632  1.00 66.82  ? 61  GLN H OE1 1 
ATOM   475  N NE2 . GLN A 1 66  ? 39.462 70.919  42.459  1.00 66.16  ? 61  GLN H NE2 1 
ATOM   476  N N   . LYS A 1 67  ? 39.892 73.876  37.802  1.00 38.76  ? 62  LYS H N   1 
ATOM   477  C CA  . LYS A 1 67  ? 39.110 74.510  36.765  1.00 39.34  ? 62  LYS H CA  1 
ATOM   478  C C   . LYS A 1 67  ? 38.688 73.569  35.615  1.00 38.73  ? 62  LYS H C   1 
ATOM   479  O O   . LYS A 1 67  ? 37.627 73.715  35.054  1.00 37.60  ? 62  LYS H O   1 
ATOM   480  C CB  . LYS A 1 67  ? 39.901 75.697  36.228  1.00 40.84  ? 62  LYS H CB  1 
ATOM   481  C CG  . LYS A 1 67  ? 39.305 76.324  34.995  1.00 44.15  ? 62  LYS H CG  1 
ATOM   482  C CD  . LYS A 1 67  ? 39.940 77.657  34.687  1.00 45.84  ? 62  LYS H CD  1 
ATOM   483  C CE  . LYS A 1 67  ? 39.702 77.986  33.230  1.00 46.99  ? 62  LYS H CE  1 
ATOM   484  N NZ  . LYS A 1 67  ? 39.938 79.417  32.972  1.00 46.97  ? 62  LYS H NZ  1 
ATOM   485  N N   . PHE A 1 68  ? 39.542 72.624  35.264  1.00 41.81  ? 63  PHE H N   1 
ATOM   486  C CA  . PHE A 1 68  ? 39.325 71.741  34.106  1.00 42.00  ? 63  PHE H CA  1 
ATOM   487  C C   . PHE A 1 68  ? 38.864 70.339  34.470  1.00 41.86  ? 63  PHE H C   1 
ATOM   488  O O   . PHE A 1 68  ? 38.705 69.488  33.605  1.00 42.02  ? 63  PHE H O   1 
ATOM   489  C CB  . PHE A 1 68  ? 40.607 71.669  33.262  1.00 42.30  ? 63  PHE H CB  1 
ATOM   490  C CG  . PHE A 1 68  ? 40.939 72.957  32.573  1.00 37.15  ? 63  PHE H CG  1 
ATOM   491  C CD1 . PHE A 1 68  ? 40.403 73.252  31.340  1.00 37.94  ? 63  PHE H CD1 1 
ATOM   492  C CD2 . PHE A 1 68  ? 41.773 73.872  33.163  1.00 36.06  ? 63  PHE H CD2 1 
ATOM   493  C CE1 . PHE A 1 68  ? 40.706 74.450  30.709  1.00 38.01  ? 63  PHE H CE1 1 
ATOM   494  C CE2 . PHE A 1 68  ? 42.078 75.064  32.545  1.00 35.90  ? 63  PHE H CE2 1 
ATOM   495  C CZ  . PHE A 1 68  ? 41.551 75.358  31.313  1.00 34.32  ? 63  PHE H CZ  1 
ATOM   496  N N   . LYS A 1 69  ? 38.629 70.096  35.745  1.00 41.66  ? 64  LYS H N   1 
ATOM   497  C CA  . LYS A 1 69  ? 37.962 68.872  36.137  1.00 45.51  ? 64  LYS H CA  1 
ATOM   498  C C   . LYS A 1 69  ? 36.584 68.892  35.476  1.00 46.71  ? 64  LYS H C   1 
ATOM   499  O O   . LYS A 1 69  ? 35.918 69.938  35.397  1.00 40.59  ? 64  LYS H O   1 
ATOM   500  C CB  . LYS A 1 69  ? 37.804 68.805  37.654  1.00 48.76  ? 64  LYS H CB  1 
ATOM   501  C CG  . LYS A 1 69  ? 39.049 68.326  38.359  1.00 50.90  ? 64  LYS H CG  1 
ATOM   502  C CD  . LYS A 1 69  ? 38.744 67.217  39.342  1.00 55.23  ? 64  LYS H CD  1 
ATOM   503  C CE  . LYS A 1 69  ? 38.794 67.717  40.775  1.00 58.30  ? 64  LYS H CE  1 
ATOM   504  N NZ  . LYS A 1 69  ? 38.120 66.743  41.679  1.00 62.06  ? 64  LYS H NZ  1 
ATOM   505  N N   . GLY A 1 70  ? 36.171 67.761  34.937  1.00 47.95  ? 65  GLY H N   1 
ATOM   506  C CA  . GLY A 1 70  ? 34.897 67.722  34.231  1.00 50.60  ? 65  GLY H CA  1 
ATOM   507  C C   . GLY A 1 70  ? 35.061 68.069  32.757  1.00 50.85  ? 65  GLY H C   1 
ATOM   508  O O   . GLY A 1 70  ? 34.534 67.335  31.901  1.00 55.75  ? 65  GLY H O   1 
ATOM   509  N N   . LYS A 1 71  ? 35.769 69.161  32.431  1.00 42.50  ? 66  LYS H N   1 
ATOM   510  C CA  . LYS A 1 71  ? 35.999 69.448  31.031  1.00 38.82  ? 66  LYS H CA  1 
ATOM   511  C C   . LYS A 1 71  ? 36.953 68.436  30.388  1.00 38.01  ? 66  LYS H C   1 
ATOM   512  O O   . LYS A 1 71  ? 36.633 67.889  29.332  1.00 37.16  ? 66  LYS H O   1 
ATOM   513  C CB  . LYS A 1 71  ? 36.479 70.862  30.738  1.00 39.94  ? 66  LYS H CB  1 
ATOM   514  C CG  . LYS A 1 71  ? 36.465 71.074  29.203  1.00 40.87  ? 66  LYS H CG  1 
ATOM   515  C CD  . LYS A 1 71  ? 36.137 72.474  28.751  1.00 40.44  ? 66  LYS H CD  1 
ATOM   516  C CE  . LYS A 1 71  ? 34.690 72.878  29.002  1.00 39.62  ? 66  LYS H CE  1 
ATOM   517  N NZ  . LYS A 1 71  ? 33.677 72.193  28.158  1.00 40.05  ? 66  LYS H NZ  1 
ATOM   518  N N   . ALA A 1 72  ? 38.096 68.181  31.027  1.00 34.88  ? 67  ALA H N   1 
ATOM   519  C CA  . ALA A 1 72  ? 39.155 67.374  30.422  1.00 32.36  ? 67  ALA H CA  1 
ATOM   520  C C   . ALA A 1 72  ? 39.412 66.092  31.160  1.00 33.48  ? 67  ALA H C   1 
ATOM   521  O O   . ALA A 1 72  ? 39.413 66.084  32.389  1.00 36.03  ? 67  ALA H O   1 
ATOM   522  C CB  . ALA A 1 72  ? 40.437 68.170  30.338  1.00 30.78  ? 67  ALA H CB  1 
ATOM   523  N N   . THR A 1 73  ? 39.660 65.027  30.389  1.00 35.73  ? 68  THR H N   1 
ATOM   524  C CA  . THR A 1 73  ? 40.088 63.700  30.877  1.00 35.66  ? 68  THR H CA  1 
ATOM   525  C C   . THR A 1 73  ? 41.354 63.303  30.140  1.00 35.11  ? 68  THR H C   1 
ATOM   526  O O   . THR A 1 73  ? 41.397 63.398  28.929  1.00 34.62  ? 68  THR H O   1 
ATOM   527  C CB  . THR A 1 73  ? 39.012 62.652  30.594  1.00 35.20  ? 68  THR H CB  1 
ATOM   528  O OG1 . THR A 1 73  ? 37.868 63.007  31.330  1.00 35.07  ? 68  THR H OG1 1 
ATOM   529  C CG2 . THR A 1 73  ? 39.412 61.254  31.030  1.00 37.03  ? 68  THR H CG2 1 
ATOM   530  N N   . LEU A 1 74  ? 42.371 62.859  30.875  1.00 35.89  ? 69  LEU H N   1 
ATOM   531  C CA  . LEU A 1 74  ? 43.673 62.524  30.302  1.00 35.77  ? 69  LEU H CA  1 
ATOM   532  C C   . LEU A 1 74  ? 43.875 61.033  30.364  1.00 36.65  ? 69  LEU H C   1 
ATOM   533  O O   . LEU A 1 74  ? 43.680 60.436  31.403  1.00 35.86  ? 69  LEU H O   1 
ATOM   534  C CB  . LEU A 1 74  ? 44.801 63.194  31.087  1.00 37.98  ? 69  LEU H CB  1 
ATOM   535  C CG  . LEU A 1 74  ? 44.838 64.733  31.223  1.00 37.04  ? 69  LEU H CG  1 
ATOM   536  C CD1 . LEU A 1 74  ? 46.190 65.186  31.739  1.00 36.86  ? 69  LEU H CD1 1 
ATOM   537  C CD2 . LEU A 1 74  ? 44.534 65.414  29.904  1.00 35.87  ? 69  LEU H CD2 1 
ATOM   538  N N   . THR A 1 75  ? 44.272 60.444  29.244  1.00 39.39  ? 70  THR H N   1 
ATOM   539  C CA  . THR A 1 75  ? 44.607 59.018  29.165  1.00 40.80  ? 70  THR H CA  1 
ATOM   540  C C   . THR A 1 75  ? 45.854 58.814  28.317  1.00 40.62  ? 70  THR H C   1 
ATOM   541  O O   . THR A 1 75  ? 46.236 59.667  27.522  1.00 39.01  ? 70  THR H O   1 
ATOM   542  C CB  . THR A 1 75  ? 43.502 58.179  28.500  1.00 40.77  ? 70  THR H CB  1 
ATOM   543  O OG1 . THR A 1 75  ? 43.368 58.580  27.135  1.00 46.03  ? 70  THR H OG1 1 
ATOM   544  C CG2 . THR A 1 75  ? 42.172 58.352  29.202  1.00 42.19  ? 70  THR H CG2 1 
ATOM   545  N N   . VAL A 1 76  ? 46.438 57.640  28.474  1.00 40.26  ? 71  VAL H N   1 
ATOM   546  C CA  . VAL A 1 76  ? 47.621 57.225  27.740  1.00 42.01  ? 71  VAL H CA  1 
ATOM   547  C C   . VAL A 1 76  ? 47.345 55.820  27.219  1.00 45.15  ? 71  VAL H C   1 
ATOM   548  O O   . VAL A 1 76  ? 46.592 55.060  27.829  1.00 43.16  ? 71  VAL H O   1 
ATOM   549  C CB  . VAL A 1 76  ? 48.873 57.182  28.642  1.00 40.51  ? 71  VAL H CB  1 
ATOM   550  C CG1 . VAL A 1 76  ? 49.363 58.586  28.943  1.00 42.09  ? 71  VAL H CG1 1 
ATOM   551  C CG2 . VAL A 1 76  ? 48.600 56.441  29.948  1.00 41.02  ? 71  VAL H CG2 1 
ATOM   552  N N   . ASP A 1 77  ? 47.957 55.475  26.100  1.00 45.88  ? 72  ASP H N   1 
ATOM   553  C CA  . ASP A 1 77  ? 47.928 54.105  25.624  1.00 46.58  ? 72  ASP H CA  1 
ATOM   554  C C   . ASP A 1 77  ? 49.359 53.664  25.336  1.00 46.49  ? 72  ASP H C   1 
ATOM   555  O O   . ASP A 1 77  ? 49.939 54.024  24.312  1.00 43.78  ? 72  ASP H O   1 
ATOM   556  C CB  . ASP A 1 77  ? 47.030 53.962  24.395  1.00 45.37  ? 72  ASP H CB  1 
ATOM   557  C CG  . ASP A 1 77  ? 47.292 52.668  23.627  1.00 46.94  ? 72  ASP H CG  1 
ATOM   558  O OD1 . ASP A 1 77  ? 47.669 51.645  24.238  1.00 49.17  ? 72  ASP H OD1 1 
ATOM   559  O OD2 . ASP A 1 77  ? 47.160 52.685  22.393  1.00 51.08  ? 72  ASP H OD2 1 
ATOM   560  N N   . LYS A 1 78  ? 49.899 52.862  26.246  1.00 50.29  ? 73  LYS H N   1 
ATOM   561  C CA  . LYS A 1 78  ? 51.241 52.317  26.122  1.00 53.82  ? 73  LYS H CA  1 
ATOM   562  C C   . LYS A 1 78  ? 51.512 51.716  24.750  1.00 51.44  ? 73  LYS H C   1 
ATOM   563  O O   . LYS A 1 78  ? 52.463 52.116  24.097  1.00 55.52  ? 73  LYS H O   1 
ATOM   564  C CB  . LYS A 1 78  ? 51.474 51.253  27.181  1.00 61.55  ? 73  LYS H CB  1 
ATOM   565  C CG  . LYS A 1 78  ? 51.879 51.782  28.554  1.00 69.32  ? 73  LYS H CG  1 
ATOM   566  C CD  . LYS A 1 78  ? 52.165 50.651  29.548  1.00 79.02  ? 73  LYS H CD  1 
ATOM   567  C CE  . LYS A 1 78  ? 52.894 49.451  28.928  1.00 81.55  ? 73  LYS H CE  1 
ATOM   568  N NZ  . LYS A 1 78  ? 53.403 48.492  29.946  1.00 87.65  ? 73  LYS H NZ  1 
ATOM   569  N N   . SER A 1 79  ? 50.661 50.786  24.314  1.00 51.63  ? 74  SER H N   1 
ATOM   570  C CA  . SER A 1 79  ? 50.809 50.056  23.020  1.00 48.89  ? 74  SER H CA  1 
ATOM   571  C C   . SER A 1 79  ? 51.270 50.929  21.861  1.00 47.00  ? 74  SER H C   1 
ATOM   572  O O   . SER A 1 79  ? 52.051 50.499  20.998  1.00 47.30  ? 74  SER H O   1 
ATOM   573  C CB  . SER A 1 79  ? 49.481 49.404  22.603  1.00 50.54  ? 74  SER H CB  1 
ATOM   574  O OG  . SER A 1 79  ? 49.240 48.187  23.287  1.00 51.85  ? 74  SER H OG  1 
ATOM   575  N N   . SER A 1 80  ? 50.763 52.153  21.842  1.00 42.88  ? 75  SER H N   1 
ATOM   576  C CA  . SER A 1 80  ? 51.079 53.081  20.794  1.00 41.37  ? 75  SER H CA  1 
ATOM   577  C C   . SER A 1 80  ? 51.846 54.316  21.234  1.00 40.91  ? 75  SER H C   1 
ATOM   578  O O   . SER A 1 80  ? 52.041 55.218  20.409  1.00 39.24  ? 75  SER H O   1 
ATOM   579  C CB  . SER A 1 80  ? 49.776 53.499  20.133  1.00 42.00  ? 75  SER H CB  1 
ATOM   580  O OG  . SER A 1 80  ? 49.022 54.325  20.986  1.00 41.82  ? 75  SER H OG  1 
ATOM   581  N N   . SER A 1 81  ? 52.275 54.380  22.502  1.00 39.04  ? 76  SER H N   1 
ATOM   582  C CA  . SER A 1 81  ? 53.001 55.558  23.036  1.00 39.58  ? 76  SER H CA  1 
ATOM   583  C C   . SER A 1 81  ? 52.321 56.865  22.615  1.00 38.43  ? 76  SER H C   1 
ATOM   584  O O   . SER A 1 81  ? 52.960 57.787  22.069  1.00 34.73  ? 76  SER H O   1 
ATOM   585  C CB  . SER A 1 81  ? 54.465 55.557  22.567  1.00 39.81  ? 76  SER H CB  1 
ATOM   586  O OG  . SER A 1 81  ? 55.113 54.335  22.890  1.00 41.19  ? 76  SER H OG  1 
ATOM   587  N N   . THR A 1 82  ? 51.008 56.895  22.834  1.00 37.41  ? 77  THR H N   1 
ATOM   588  C CA  . THR A 1 82  ? 50.175 58.049  22.493  1.00 39.76  ? 77  THR H CA  1 
ATOM   589  C C   . THR A 1 82  ? 49.415 58.542  23.719  1.00 37.55  ? 77  THR H C   1 
ATOM   590  O O   . THR A 1 82  ? 48.866 57.755  24.482  1.00 35.28  ? 77  THR H O   1 
ATOM   591  C CB  . THR A 1 82  ? 49.160 57.746  21.383  1.00 38.96  ? 77  THR H CB  1 
ATOM   592  O OG1 . THR A 1 82  ? 49.853 57.351  20.202  1.00 40.10  ? 77  THR H OG1 1 
ATOM   593  C CG2 . THR A 1 82  ? 48.318 58.982  21.051  1.00 39.72  ? 77  THR H CG2 1 
ATOM   594  N N   . ALA A 1 83  ? 49.384 59.865  23.851  1.00 36.78  ? 78  ALA H N   1 
ATOM   595  C CA  . ALA A 1 83  ? 48.757 60.558  24.949  1.00 34.94  ? 78  ALA H CA  1 
ATOM   596  C C   . ALA A 1 83  ? 47.467 61.140  24.417  1.00 34.55  ? 78  ALA H C   1 
ATOM   597  O O   . ALA A 1 83  ? 47.480 61.740  23.351  1.00 29.45  ? 78  ALA H O   1 
ATOM   598  C CB  . ALA A 1 83  ? 49.667 61.676  25.410  1.00 35.15  ? 78  ALA H CB  1 
ATOM   599  N N   . TYR A 1 84  ? 46.370 60.974  25.162  1.00 36.27  ? 79  TYR H N   1 
ATOM   600  C CA  . TYR A 1 84  ? 45.048 61.551  24.799  1.00 35.58  ? 79  TYR H CA  1 
ATOM   601  C C   . TYR A 1 84  ? 44.445 62.516  25.829  1.00 33.99  ? 79  TYR H C   1 
ATOM   602  O O   . TYR A 1 84  ? 44.468 62.236  27.017  1.00 34.87  ? 79  TYR H O   1 
ATOM   603  C CB  . TYR A 1 84  ? 44.018 60.448  24.589  1.00 34.64  ? 79  TYR H CB  1 
ATOM   604  C CG  . TYR A 1 84  ? 44.364 59.453  23.516  1.00 35.76  ? 79  TYR H CG  1 
ATOM   605  C CD1 . TYR A 1 84  ? 44.213 59.773  22.155  1.00 35.52  ? 79  TYR H CD1 1 
ATOM   606  C CD2 . TYR A 1 84  ? 44.805 58.180  23.854  1.00 38.16  ? 79  TYR H CD2 1 
ATOM   607  C CE1 . TYR A 1 84  ? 44.510 58.852  21.168  1.00 36.65  ? 79  TYR H CE1 1 
ATOM   608  C CE2 . TYR A 1 84  ? 45.100 57.236  22.877  1.00 38.95  ? 79  TYR H CE2 1 
ATOM   609  C CZ  . TYR A 1 84  ? 44.957 57.570  21.546  1.00 39.02  ? 79  TYR H CZ  1 
ATOM   610  O OH  . TYR A 1 84  ? 45.266 56.624  20.610  1.00 40.06  ? 79  TYR H OH  1 
ATOM   611  N N   . MET A 1 85  ? 43.863 63.613  25.342  1.00 32.40  ? 80  MET H N   1 
ATOM   612  C CA  . MET A 1 85  ? 43.060 64.507  26.145  1.00 33.23  ? 80  MET H CA  1 
ATOM   613  C C   . MET A 1 85  ? 41.672 64.611  25.551  1.00 34.28  ? 80  MET H C   1 
ATOM   614  O O   . MET A 1 85  ? 41.529 65.108  24.433  1.00 32.91  ? 80  MET H O   1 
ATOM   615  C CB  . MET A 1 85  ? 43.660 65.906  26.203  1.00 32.71  ? 80  MET H CB  1 
ATOM   616  C CG  . MET A 1 85  ? 42.835 66.804  27.103  1.00 34.12  ? 80  MET H CG  1 
ATOM   617  S SD  . MET A 1 85  ? 43.403 68.469  27.392  1.00 34.47  ? 80  MET H SD  1 
ATOM   618  C CE  . MET A 1 85  ? 43.431 69.087  25.708  1.00 32.38  ? 80  MET H CE  1 
ATOM   619  N N   . HIS A 1 86  ? 40.672 64.166  26.316  1.00 34.51  ? 81  HIS H N   1 
ATOM   620  C CA  . HIS A 1 86  ? 39.256 64.287  25.958  1.00 37.39  ? 81  HIS H CA  1 
ATOM   621  C C   . HIS A 1 86  ? 38.680 65.566  26.565  1.00 35.24  ? 81  HIS H C   1 
ATOM   622  O O   . HIS A 1 86  ? 38.712 65.780  27.775  1.00 34.24  ? 81  HIS H O   1 
ATOM   623  C CB  . HIS A 1 86  ? 38.430 63.099  26.450  1.00 42.32  ? 81  HIS H CB  1 
ATOM   624  C CG  . HIS A 1 86  ? 38.983 61.759  26.062  1.00 53.66  ? 81  HIS H CG  1 
ATOM   625  N ND1 . HIS A 1 86  ? 40.084 61.200  26.684  1.00 62.13  ? 81  HIS H ND1 1 
ATOM   626  C CD2 . HIS A 1 86  ? 38.568 60.848  25.144  1.00 59.40  ? 81  HIS H CD2 1 
ATOM   627  C CE1 . HIS A 1 86  ? 40.333 60.014  26.154  1.00 66.43  ? 81  HIS H CE1 1 
ATOM   628  N NE2 . HIS A 1 86  ? 39.431 59.777  25.215  1.00 63.61  ? 81  HIS H NE2 1 
ATOM   629  N N   . LEU A 1 87  ? 38.196 66.426  25.693  1.00 32.84  ? 82  LEU H N   1 
ATOM   630  C CA  . LEU A 1 87  ? 37.404 67.565  26.068  1.00 34.05  ? 82  LEU H CA  1 
ATOM   631  C C   . LEU A 1 87  ? 35.960 67.221  25.736  1.00 37.17  ? 82  LEU H C   1 
ATOM   632  O O   . LEU A 1 87  ? 35.674 66.633  24.681  1.00 38.88  ? 82  LEU H O   1 
ATOM   633  C CB  . LEU A 1 87  ? 37.868 68.797  25.298  1.00 33.72  ? 82  LEU H CB  1 
ATOM   634  C CG  . LEU A 1 87  ? 39.355 69.105  25.485  1.00 32.02  ? 82  LEU H CG  1 
ATOM   635  C CD1 . LEU A 1 87  ? 39.797 70.150  24.491  1.00 33.08  ? 82  LEU H CD1 1 
ATOM   636  C CD2 . LEU A 1 87  ? 39.633 69.565  26.916  1.00 33.25  ? 82  LEU H CD2 1 
ATOM   637  N N   . ASN A 1 88  A 35.064 67.546  26.661  1.00 38.66  ? 82  ASN H N   1 
ATOM   638  C CA  . ASN A 1 88  A 33.634 67.366  26.457  1.00 40.25  ? 82  ASN H CA  1 
ATOM   639  C C   . ASN A 1 88  A 32.893 68.661  26.753  1.00 35.31  ? 82  ASN H C   1 
ATOM   640  O O   . ASN A 1 88  A 33.493 69.624  27.206  1.00 34.40  ? 82  ASN H O   1 
ATOM   641  C CB  . ASN A 1 88  A 33.122 66.177  27.297  1.00 43.47  ? 82  ASN H CB  1 
ATOM   642  C CG  . ASN A 1 88  A 33.267 66.409  28.784  1.00 47.22  ? 82  ASN H CG  1 
ATOM   643  O OD1 . ASN A 1 88  A 32.886 67.461  29.290  1.00 47.95  ? 82  ASN H OD1 1 
ATOM   644  N ND2 . ASN A 1 88  A 33.806 65.430  29.497  1.00 50.85  ? 82  ASN H ND2 1 
ATOM   645  N N   . SER A 1 89  B 31.599 68.668  26.451  1.00 34.26  ? 82  SER H N   1 
ATOM   646  C CA  . SER A 1 89  B 30.723 69.828  26.619  1.00 34.34  ? 82  SER H CA  1 
ATOM   647  C C   . SER A 1 89  B 31.332 71.115  26.067  1.00 33.67  ? 82  SER H C   1 
ATOM   648  O O   . SER A 1 89  B 31.403 72.124  26.764  1.00 33.44  ? 82  SER H O   1 
ATOM   649  C CB  . SER A 1 89  B 30.379 70.041  28.108  1.00 36.86  ? 82  SER H CB  1 
ATOM   650  O OG  . SER A 1 89  B 30.107 68.837  28.792  1.00 37.78  ? 82  SER H OG  1 
ATOM   651  N N   . LEU A 1 90  C 31.781 71.084  24.824  1.00 36.38  ? 82  LEU H N   1 
ATOM   652  C CA  . LEU A 1 90  C 32.615 72.177  24.321  1.00 37.64  ? 82  LEU H CA  1 
ATOM   653  C C   . LEU A 1 90  C 31.845 73.506  24.170  1.00 37.72  ? 82  LEU H C   1 
ATOM   654  O O   . LEU A 1 90  C 30.665 73.489  23.870  1.00 35.48  ? 82  LEU H O   1 
ATOM   655  C CB  . LEU A 1 90  C 33.323 71.775  23.026  1.00 40.05  ? 82  LEU H CB  1 
ATOM   656  C CG  . LEU A 1 90  C 34.613 70.941  23.172  1.00 41.88  ? 82  LEU H CG  1 
ATOM   657  C CD1 . LEU A 1 90  C 35.064 70.499  21.796  1.00 44.24  ? 82  LEU H CD1 1 
ATOM   658  C CD2 . LEU A 1 90  C 35.789 71.644  23.845  1.00 41.70  ? 82  LEU H CD2 1 
ATOM   659  N N   . THR A 1 91  ? 32.537 74.630  24.404  1.00 36.64  ? 83  THR H N   1 
ATOM   660  C CA  . THR A 1 91  ? 31.982 76.005  24.317  1.00 37.28  ? 83  THR H CA  1 
ATOM   661  C C   . THR A 1 91  ? 32.960 76.901  23.576  1.00 37.75  ? 83  THR H C   1 
ATOM   662  O O   . THR A 1 91  ? 34.132 76.537  23.455  1.00 36.56  ? 83  THR H O   1 
ATOM   663  C CB  . THR A 1 91  ? 31.826 76.666  25.713  1.00 37.62  ? 83  THR H CB  1 
ATOM   664  O OG1 . THR A 1 91  ? 33.125 76.981  26.252  1.00 35.59  ? 83  THR H OG1 1 
ATOM   665  C CG2 . THR A 1 91  ? 31.113 75.749  26.688  1.00 37.20  ? 83  THR H CG2 1 
ATOM   666  N N   . SER A 1 92  ? 32.520 78.090  23.143  1.00 39.15  ? 84  SER H N   1 
ATOM   667  C CA  . SER A 1 92  ? 33.426 79.045  22.422  1.00 40.01  ? 84  SER H CA  1 
ATOM   668  C C   . SER A 1 92  ? 34.690 79.449  23.207  1.00 41.52  ? 84  SER H C   1 
ATOM   669  O O   . SER A 1 92  ? 35.771 79.664  22.627  1.00 40.06  ? 84  SER H O   1 
ATOM   670  C CB  . SER A 1 92  ? 32.684 80.289  21.974  1.00 37.78  ? 84  SER H CB  1 
ATOM   671  O OG  . SER A 1 92  ? 31.935 80.788  23.030  1.00 40.38  ? 84  SER H OG  1 
ATOM   672  N N   . GLU A 1 93  ? 34.558 79.493  24.531  1.00 45.36  ? 85  GLU H N   1 
ATOM   673  C CA  . GLU A 1 93  ? 35.698 79.695  25.430  1.00 45.53  ? 85  GLU H CA  1 
ATOM   674  C C   . GLU A 1 93  ? 36.755 78.579  25.360  1.00 42.66  ? 85  GLU H C   1 
ATOM   675  O O   . GLU A 1 93  ? 37.907 78.817  25.668  1.00 42.53  ? 85  GLU H O   1 
ATOM   676  C CB  . GLU A 1 93  ? 35.206 79.890  26.865  1.00 49.30  ? 85  GLU H CB  1 
ATOM   677  C CG  . GLU A 1 93  ? 34.620 81.275  27.122  1.00 54.41  ? 85  GLU H CG  1 
ATOM   678  C CD  . GLU A 1 93  ? 33.132 81.395  26.870  1.00 59.89  ? 85  GLU H CD  1 
ATOM   679  O OE1 . GLU A 1 93  ? 32.433 80.361  26.764  1.00 59.51  ? 85  GLU H OE1 1 
ATOM   680  O OE2 . GLU A 1 93  ? 32.660 82.548  26.804  1.00 66.40  ? 85  GLU H OE2 1 
ATOM   681  N N   . ASP A 1 94  ? 36.350 77.375  24.955  1.00 39.94  ? 86  ASP H N   1 
ATOM   682  C CA  . ASP A 1 94  ? 37.278 76.288  24.680  1.00 38.09  ? 86  ASP H CA  1 
ATOM   683  C C   . ASP A 1 94  ? 38.005 76.408  23.328  1.00 36.73  ? 86  ASP H C   1 
ATOM   684  O O   . ASP A 1 94  ? 38.917 75.629  23.063  1.00 36.35  ? 86  ASP H O   1 
ATOM   685  C CB  . ASP A 1 94  ? 36.559 74.932  24.739  1.00 38.26  ? 86  ASP H CB  1 
ATOM   686  C CG  . ASP A 1 94  ? 35.863 74.687  26.065  1.00 38.35  ? 86  ASP H CG  1 
ATOM   687  O OD1 . ASP A 1 94  ? 36.430 75.032  27.124  1.00 35.21  ? 86  ASP H OD1 1 
ATOM   688  O OD2 . ASP A 1 94  ? 34.744 74.134  26.037  1.00 39.18  ? 86  ASP H OD2 1 
ATOM   689  N N   . SER A 1 95  ? 37.585 77.330  22.462  1.00 37.30  ? 87  SER H N   1 
ATOM   690  C CA  . SER A 1 95  ? 38.318 77.613  21.217  1.00 36.62  ? 87  SER H CA  1 
ATOM   691  C C   . SER A 1 95  ? 39.746 78.085  21.500  1.00 35.27  ? 87  SER H C   1 
ATOM   692  O O   . SER A 1 95  ? 39.952 79.206  21.957  1.00 37.95  ? 87  SER H O   1 
ATOM   693  C CB  . SER A 1 95  ? 37.610 78.677  20.384  1.00 35.23  ? 87  SER H CB  1 
ATOM   694  O OG  . SER A 1 95  ? 36.327 78.246  20.000  1.00 37.53  ? 87  SER H OG  1 
ATOM   695  N N   . ALA A 1 96  ? 40.727 77.238  21.216  1.00 33.76  ? 88  ALA H N   1 
ATOM   696  C CA  . ALA A 1 96  ? 42.113 77.527  21.580  1.00 32.70  ? 88  ALA H CA  1 
ATOM   697  C C   . ALA A 1 96  ? 43.106 76.588  20.910  1.00 32.65  ? 88  ALA H C   1 
ATOM   698  O O   . ALA A 1 96  ? 42.725 75.637  20.209  1.00 30.88  ? 88  ALA H O   1 
ATOM   699  C CB  . ALA A 1 96  ? 42.273 77.431  23.095  1.00 31.97  ? 88  ALA H CB  1 
ATOM   700  N N   . VAL A 1 97  ? 44.386 76.889  21.144  1.00 32.58  ? 89  VAL H N   1 
ATOM   701  C CA  . VAL A 1 97  ? 45.504 75.999  20.851  1.00 31.86  ? 89  VAL H CA  1 
ATOM   702  C C   . VAL A 1 97  ? 45.888 75.275  22.119  1.00 33.06  ? 89  VAL H C   1 
ATOM   703  O O   . VAL A 1 97  ? 46.115 75.907  23.166  1.00 32.94  ? 89  VAL H O   1 
ATOM   704  C CB  . VAL A 1 97  ? 46.740 76.753  20.330  1.00 34.03  ? 89  VAL H CB  1 
ATOM   705  C CG1 . VAL A 1 97  ? 47.889 75.786  20.073  1.00 33.53  ? 89  VAL H CG1 1 
ATOM   706  C CG2 . VAL A 1 97  ? 46.376 77.502  19.042  1.00 35.79  ? 89  VAL H CG2 1 
ATOM   707  N N   . TYR A 1 98  ? 45.969 73.945  21.970  1.00 32.91  ? 90  TYR H N   1 
ATOM   708  C CA  . TYR A 1 98  ? 46.169 72.997  23.041  1.00 33.01  ? 90  TYR H CA  1 
ATOM   709  C C   . TYR A 1 98  ? 47.492 72.287  22.803  1.00 33.21  ? 90  TYR H C   1 
ATOM   710  O O   . TYR A 1 98  ? 47.722 71.731  21.734  1.00 33.71  ? 90  TYR H O   1 
ATOM   711  C CB  . TYR A 1 98  ? 45.010 71.998  23.114  1.00 32.30  ? 90  TYR H CB  1 
ATOM   712  C CG  . TYR A 1 98  ? 43.719 72.594  23.623  1.00 34.86  ? 90  TYR H CG  1 
ATOM   713  C CD1 . TYR A 1 98  ? 43.465 72.706  24.989  1.00 37.63  ? 90  TYR H CD1 1 
ATOM   714  C CD2 . TYR A 1 98  ? 42.756 73.054  22.744  1.00 35.43  ? 90  TYR H CD2 1 
ATOM   715  C CE1 . TYR A 1 98  ? 42.274 73.247  25.455  1.00 39.03  ? 90  TYR H CE1 1 
ATOM   716  C CE2 . TYR A 1 98  ? 41.563 73.592  23.197  1.00 38.57  ? 90  TYR H CE2 1 
ATOM   717  C CZ  . TYR A 1 98  ? 41.317 73.697  24.551  1.00 38.47  ? 90  TYR H CZ  1 
ATOM   718  O OH  . TYR A 1 98  ? 40.119 74.245  24.980  1.00 33.94  ? 90  TYR H OH  1 
ATOM   719  N N   . TYR A 1 99  ? 48.382 72.372  23.785  1.00 34.46  ? 91  TYR H N   1 
ATOM   720  C CA  . TYR A 1 99  ? 49.716 71.796  23.665  1.00 35.62  ? 91  TYR H CA  1 
ATOM   721  C C   . TYR A 1 99  ? 49.741 70.565  24.532  1.00 37.61  ? 91  TYR H C   1 
ATOM   722  O O   . TYR A 1 99  ? 49.115 70.514  25.606  1.00 37.07  ? 91  TYR H O   1 
ATOM   723  C CB  . TYR A 1 99  ? 50.832 72.757  24.108  1.00 33.01  ? 91  TYR H CB  1 
ATOM   724  C CG  . TYR A 1 99  ? 50.887 74.045  23.339  1.00 31.64  ? 91  TYR H CG  1 
ATOM   725  C CD1 . TYR A 1 99  ? 51.432 74.083  22.049  1.00 31.53  ? 91  TYR H CD1 1 
ATOM   726  C CD2 . TYR A 1 99  ? 50.403 75.241  23.899  1.00 29.90  ? 91  TYR H CD2 1 
ATOM   727  C CE1 . TYR A 1 99  ? 51.461 75.256  21.318  1.00 31.12  ? 91  TYR H CE1 1 
ATOM   728  C CE2 . TYR A 1 99  ? 50.455 76.423  23.190  1.00 30.07  ? 91  TYR H CE2 1 
ATOM   729  C CZ  . TYR A 1 99  ? 50.991 76.429  21.896  1.00 33.27  ? 91  TYR H CZ  1 
ATOM   730  O OH  . TYR A 1 99  ? 51.043 77.596  21.156  1.00 34.25  ? 91  TYR H OH  1 
ATOM   731  N N   . CYS A 1 100 ? 50.482 69.585  24.040  1.00 37.55  ? 92  CYS H N   1 
ATOM   732  C CA  . CYS A 1 100 ? 50.842 68.410  24.792  1.00 37.13  ? 92  CYS H CA  1 
ATOM   733  C C   . CYS A 1 100 ? 52.327 68.648  25.046  1.00 33.43  ? 92  CYS H C   1 
ATOM   734  O O   . CYS A 1 100 ? 53.013 69.246  24.214  1.00 32.14  ? 92  CYS H O   1 
ATOM   735  C CB  . CYS A 1 100 ? 50.547 67.186  23.939  1.00 41.27  ? 92  CYS H CB  1 
ATOM   736  S SG  . CYS A 1 100 ? 51.394 65.652  24.321  1.00 53.56  ? 92  CYS H SG  1 
ATOM   737  N N   . THR A 1 101 ? 52.816 68.231  26.203  1.00 30.42  ? 93  THR H N   1 
ATOM   738  C CA  . THR A 1 101 ? 54.202 68.442  26.570  1.00 28.91  ? 93  THR H CA  1 
ATOM   739  C C   . THR A 1 101 ? 54.742 67.159  27.166  1.00 30.45  ? 93  THR H C   1 
ATOM   740  O O   . THR A 1 101 ? 53.991 66.415  27.785  1.00 27.03  ? 93  THR H O   1 
ATOM   741  C CB  . THR A 1 101 ? 54.365 69.536  27.659  1.00 30.29  ? 93  THR H CB  1 
ATOM   742  O OG1 . THR A 1 101 ? 54.202 68.967  28.966  1.00 29.58  ? 93  THR H OG1 1 
ATOM   743  C CG2 . THR A 1 101 ? 53.389 70.701  27.490  1.00 31.45  ? 93  THR H CG2 1 
ATOM   744  N N   . SER A 1 102 ? 56.044 66.911  27.018  1.00 30.44  ? 94  SER H N   1 
ATOM   745  C CA  . SER A 1 102 ? 56.690 65.877  27.829  1.00 34.98  ? 94  SER H CA  1 
ATOM   746  C C   . SER A 1 102 ? 57.737 66.563  28.707  1.00 34.77  ? 94  SER H C   1 
ATOM   747  O O   . SER A 1 102 ? 58.601 67.268  28.197  1.00 32.54  ? 94  SER H O   1 
ATOM   748  C CB  . SER A 1 102 ? 57.295 64.758  26.964  1.00 34.28  ? 94  SER H CB  1 
ATOM   749  O OG  . SER A 1 102 ? 58.359 65.250  26.181  1.00 36.77  ? 94  SER H OG  1 
ATOM   750  N N   . SER A 1 103 ? 57.657 66.380  30.016  1.00 34.52  ? 95  SER H N   1 
ATOM   751  C CA  . SER A 1 103 ? 58.651 67.022  30.876  1.00 38.99  ? 95  SER H CA  1 
ATOM   752  C C   . SER A 1 103 ? 59.206 66.110  31.940  1.00 37.89  ? 95  SER H C   1 
ATOM   753  O O   . SER A 1 103 ? 58.778 64.973  32.113  1.00 35.59  ? 95  SER H O   1 
ATOM   754  C CB  . SER A 1 103 ? 58.116 68.315  31.501  1.00 41.60  ? 95  SER H CB  1 
ATOM   755  O OG  . SER A 1 103 ? 59.181 69.271  31.688  1.00 41.51  ? 95  SER H OG  1 
ATOM   756  N N   . THR A 1 104 ? 60.242 66.618  32.584  1.00 37.57  ? 96  THR H N   1 
ATOM   757  C CA  . THR A 1 104 ? 60.950 65.913  33.615  1.00 36.53  ? 96  THR H CA  1 
ATOM   758  C C   . THR A 1 104 ? 61.274 66.991  34.615  1.00 37.66  ? 96  THR H C   1 
ATOM   759  O O   . THR A 1 104 ? 60.914 68.167  34.387  1.00 37.99  ? 96  THR H O   1 
ATOM   760  C CB  . THR A 1 104 ? 62.231 65.296  33.050  1.00 37.36  ? 96  THR H CB  1 
ATOM   761  O OG1 . THR A 1 104 ? 63.163 66.325  32.728  1.00 35.26  ? 96  THR H OG1 1 
ATOM   762  C CG2 . THR A 1 104 ? 61.946 64.496  31.778  1.00 38.33  ? 96  THR H CG2 1 
ATOM   763  N N   . SER A 1 105 ? 61.970 66.625  35.692  1.00 33.21  ? 97  SER H N   1 
ATOM   764  C CA  . SER A 1 105 ? 62.471 67.613  36.628  1.00 32.95  ? 97  SER H CA  1 
ATOM   765  C C   . SER A 1 105 ? 63.467 68.594  36.020  1.00 30.98  ? 97  SER H C   1 
ATOM   766  O O   . SER A 1 105 ? 63.659 69.654  36.568  1.00 29.48  ? 97  SER H O   1 
ATOM   767  C CB  . SER A 1 105 ? 63.126 66.938  37.812  1.00 36.02  ? 97  SER H CB  1 
ATOM   768  O OG  . SER A 1 105 ? 64.117 66.059  37.338  1.00 38.20  ? 97  SER H OG  1 
ATOM   769  N N   . VAL A 1 106 ? 64.070 68.238  34.888  1.00 30.92  ? 98  VAL H N   1 
ATOM   770  C CA  . VAL A 1 106 ? 65.064 69.071  34.197  1.00 29.69  ? 98  VAL H CA  1 
ATOM   771  C C   . VAL A 1 106 ? 64.586 69.543  32.819  1.00 30.11  ? 98  VAL H C   1 
ATOM   772  O O   . VAL A 1 106 ? 65.404 69.922  31.957  1.00 28.44  ? 98  VAL H O   1 
ATOM   773  C CB  . VAL A 1 106 ? 66.435 68.337  34.076  1.00 32.15  ? 98  VAL H CB  1 
ATOM   774  C CG1 . VAL A 1 106 ? 67.022 68.055  35.465  1.00 30.57  ? 98  VAL H CG1 1 
ATOM   775  C CG2 . VAL A 1 106 ? 66.329 67.024  33.287  1.00 32.02  ? 98  VAL H CG2 1 
ATOM   776  N N   . GLY A 1 107 ? 63.273 69.547  32.611  1.00 27.80  ? 99  GLY H N   1 
ATOM   777  C CA  . GLY A 1 107 ? 62.716 70.023  31.361  1.00 29.07  ? 99  GLY H CA  1 
ATOM   778  C C   . GLY A 1 107 ? 62.353 68.952  30.356  1.00 32.35  ? 99  GLY H C   1 
ATOM   779  O O   . GLY A 1 107 ? 62.369 67.732  30.630  1.00 31.25  ? 99  GLY H O   1 
ATOM   780  N N   . GLY A 1 108 ? 62.020 69.425  29.165  1.00 34.45  ? 101 GLY H N   1 
ATOM   781  C CA  . GLY A 1 108 ? 61.615 68.534  28.083  1.00 35.53  ? 101 GLY H CA  1 
ATOM   782  C C   . GLY A 1 108 ? 61.092 69.367  26.957  1.00 37.01  ? 101 GLY H C   1 
ATOM   783  O O   . GLY A 1 108 ? 61.537 70.487  26.775  1.00 38.19  ? 101 GLY H O   1 
ATOM   784  N N   . SER A 1 109 ? 60.138 68.844  26.204  1.00 37.44  ? 102 SER H N   1 
ATOM   785  C CA  . SER A 1 109 ? 59.618 69.625  25.110  1.00 35.21  ? 102 SER H CA  1 
ATOM   786  C C   . SER A 1 109 ? 58.112 69.618  24.987  1.00 32.46  ? 102 SER H C   1 
ATOM   787  O O   . SER A 1 109 ? 57.414 68.743  25.481  1.00 34.98  ? 102 SER H O   1 
ATOM   788  C CB  . SER A 1 109 ? 60.298 69.236  23.807  1.00 36.51  ? 102 SER H CB  1 
ATOM   789  O OG  . SER A 1 109 ? 59.789 68.024  23.326  1.00 38.96  ? 102 SER H OG  1 
ATOM   790  N N   . TRP A 1 110 ? 57.649 70.648  24.307  1.00 29.41  ? 103 TRP H N   1 
ATOM   791  C CA  . TRP A 1 110 ? 56.272 70.909  24.083  1.00 28.04  ? 103 TRP H CA  1 
ATOM   792  C C   . TRP A 1 110 ? 55.907 70.563  22.657  1.00 28.97  ? 103 TRP H C   1 
ATOM   793  O O   . TRP A 1 110 ? 56.664 70.866  21.764  1.00 28.06  ? 103 TRP H O   1 
ATOM   794  C CB  . TRP A 1 110 ? 56.076 72.392  24.223  1.00 28.17  ? 103 TRP H CB  1 
ATOM   795  C CG  . TRP A 1 110 ? 55.998 72.851  25.593  1.00 29.34  ? 103 TRP H CG  1 
ATOM   796  C CD1 . TRP A 1 110 ? 56.831 72.540  26.633  1.00 28.31  ? 103 TRP H CD1 1 
ATOM   797  C CD2 . TRP A 1 110 ? 55.024 73.743  26.108  1.00 29.54  ? 103 TRP H CD2 1 
ATOM   798  N NE1 . TRP A 1 110 ? 56.423 73.182  27.765  1.00 27.92  ? 103 TRP H NE1 1 
ATOM   799  C CE2 . TRP A 1 110 ? 55.314 73.929  27.476  1.00 28.08  ? 103 TRP H CE2 1 
ATOM   800  C CE3 . TRP A 1 110 ? 53.925 74.405  25.546  1.00 30.13  ? 103 TRP H CE3 1 
ATOM   801  C CZ2 . TRP A 1 110 ? 54.568 74.763  28.286  1.00 28.33  ? 103 TRP H CZ2 1 
ATOM   802  C CZ3 . TRP A 1 110 ? 53.164 75.244  26.367  1.00 31.99  ? 103 TRP H CZ3 1 
ATOM   803  C CH2 . TRP A 1 110 ? 53.491 75.407  27.727  1.00 30.37  ? 103 TRP H CH2 1 
ATOM   804  N N   . GLY A 1 111 ? 54.713 70.025  22.437  1.00 30.42  ? 104 GLY H N   1 
ATOM   805  C CA  . GLY A 1 111 ? 54.180 69.838  21.082  1.00 30.66  ? 104 GLY H CA  1 
ATOM   806  C C   . GLY A 1 111 ? 53.943 71.123  20.278  1.00 31.93  ? 104 GLY H C   1 
ATOM   807  O O   . GLY A 1 111 ? 53.999 72.254  20.802  1.00 31.92  ? 104 GLY H O   1 
ATOM   808  N N   . GLN A 1 112 ? 53.654 70.911  18.994  1.00 31.58  ? 105 GLN H N   1 
ATOM   809  C CA  . GLN A 1 112 ? 53.393 71.960  17.993  1.00 33.82  ? 105 GLN H CA  1 
ATOM   810  C C   . GLN A 1 112 ? 51.962 72.473  18.202  1.00 34.52  ? 105 GLN H C   1 
ATOM   811  O O   . GLN A 1 112 ? 51.639 73.579  17.824  1.00 32.15  ? 105 GLN H O   1 
ATOM   812  C CB  . GLN A 1 112 ? 53.507 71.447  16.539  1.00 37.83  ? 105 GLN H CB  1 
ATOM   813  C CG  . GLN A 1 112 ? 54.345 70.193  16.270  1.00 43.40  ? 105 GLN H CG  1 
ATOM   814  C CD  . GLN A 1 112 ? 53.852 68.887  16.949  1.00 46.58  ? 105 GLN H CD  1 
ATOM   815  O OE1 . GLN A 1 112 ? 52.679 68.512  16.868  1.00 45.85  ? 105 GLN H OE1 1 
ATOM   816  N NE2 . GLN A 1 112 ? 54.768 68.197  17.642  1.00 50.20  ? 105 GLN H NE2 1 
ATOM   817  N N   . GLY A 1 113 ? 51.096 71.632  18.761  1.00 37.95  ? 106 GLY H N   1 
ATOM   818  C CA  . GLY A 1 113 ? 49.827 72.082  19.302  1.00 40.82  ? 106 GLY H CA  1 
ATOM   819  C C   . GLY A 1 113 ? 48.694 71.866  18.321  1.00 42.30  ? 106 GLY H C   1 
ATOM   820  O O   . GLY A 1 113 ? 48.851 72.105  17.124  1.00 43.04  ? 106 GLY H O   1 
ATOM   821  N N   . THR A 1 114 ? 47.556 71.418  18.844  1.00 43.33  ? 107 THR H N   1 
ATOM   822  C CA  . THR A 1 114 ? 46.324 71.253  18.075  1.00 42.50  ? 107 THR H CA  1 
ATOM   823  C C   . THR A 1 114 ? 45.490 72.492  18.304  1.00 40.05  ? 107 THR H C   1 
ATOM   824  O O   . THR A 1 114 ? 45.223 72.862  19.448  1.00 38.83  ? 107 THR H O   1 
ATOM   825  C CB  . THR A 1 114 ? 45.494 70.041  18.561  1.00 44.24  ? 107 THR H CB  1 
ATOM   826  O OG1 . THR A 1 114 ? 46.274 68.830  18.497  1.00 41.10  ? 107 THR H OG1 1 
ATOM   827  C CG2 . THR A 1 114 ? 44.211 69.892  17.729  1.00 44.48  ? 107 THR H CG2 1 
ATOM   828  N N   . THR A 1 115 ? 45.095 73.143  17.223  1.00 37.03  ? 108 THR H N   1 
ATOM   829  C CA  . THR A 1 115 ? 44.024 74.121  17.292  1.00 36.58  ? 108 THR H CA  1 
ATOM   830  C C   . THR A 1 115 ? 42.649 73.450  17.392  1.00 37.07  ? 108 THR H C   1 
ATOM   831  O O   . THR A 1 115 ? 42.393 72.465  16.718  1.00 39.00  ? 108 THR H O   1 
ATOM   832  C CB  . THR A 1 115 ? 44.018 75.001  16.058  1.00 37.08  ? 108 THR H CB  1 
ATOM   833  O OG1 . THR A 1 115 ? 45.361 75.407  15.788  1.00 36.14  ? 108 THR H OG1 1 
ATOM   834  C CG2 . THR A 1 115 ? 43.137 76.234  16.305  1.00 37.81  ? 108 THR H CG2 1 
ATOM   835  N N   . VAL A 1 116 ? 41.789 73.996  18.260  1.00 38.03  ? 109 VAL H N   1 
ATOM   836  C CA  . VAL A 1 116 ? 40.358 73.658  18.340  1.00 32.60  ? 109 VAL H CA  1 
ATOM   837  C C   . VAL A 1 116 ? 39.552 74.930  18.144  1.00 32.85  ? 109 VAL H C   1 
ATOM   838  O O   . VAL A 1 116 ? 39.770 75.976  18.805  1.00 30.06  ? 109 VAL H O   1 
ATOM   839  C CB  . VAL A 1 116 ? 39.971 73.006  19.670  1.00 33.90  ? 109 VAL H CB  1 
ATOM   840  C CG1 . VAL A 1 116 ? 38.507 72.560  19.670  1.00 34.80  ? 109 VAL H CG1 1 
ATOM   841  C CG2 . VAL A 1 116 ? 40.846 71.790  19.932  1.00 34.60  ? 109 VAL H CG2 1 
ATOM   842  N N   . THR A 1 117 ? 38.626 74.856  17.206  1.00 31.88  ? 110 THR H N   1 
ATOM   843  C CA  . THR A 1 117 ? 37.730 75.973  16.966  1.00 33.44  ? 110 THR H CA  1 
ATOM   844  C C   . THR A 1 117 ? 36.305 75.488  17.249  1.00 33.20  ? 110 THR H C   1 
ATOM   845  O O   . THR A 1 117 ? 35.855 74.524  16.632  1.00 32.01  ? 110 THR H O   1 
ATOM   846  C CB  . THR A 1 117 ? 37.900 76.502  15.530  1.00 32.52  ? 110 THR H CB  1 
ATOM   847  O OG1 . THR A 1 117 ? 39.281 76.828  15.304  1.00 33.79  ? 110 THR H OG1 1 
ATOM   848  C CG2 . THR A 1 117 ? 37.065 77.731  15.332  1.00 32.04  ? 110 THR H CG2 1 
ATOM   849  N N   . VAL A 1 118 ? 35.617 76.155  18.180  1.00 34.01  ? 111 VAL H N   1 
ATOM   850  C CA  . VAL A 1 118 ? 34.268 75.777  18.578  1.00 35.44  ? 111 VAL H CA  1 
ATOM   851  C C   . VAL A 1 118 ? 33.292 76.822  18.056  1.00 38.27  ? 111 VAL H C   1 
ATOM   852  O O   . VAL A 1 118 ? 33.089 77.881  18.680  1.00 42.99  ? 111 VAL H O   1 
ATOM   853  C CB  . VAL A 1 118 ? 34.142 75.604  20.102  1.00 36.00  ? 111 VAL H CB  1 
ATOM   854  C CG1 . VAL A 1 118 ? 32.725 75.176  20.478  1.00 34.03  ? 111 VAL H CG1 1 
ATOM   855  C CG2 . VAL A 1 118 ? 35.148 74.571  20.601  1.00 36.37  ? 111 VAL H CG2 1 
ATOM   856  N N   . SER A 1 119 ? 32.701 76.509  16.905  1.00 39.13  ? 112 SER H N   1 
ATOM   857  C CA  . SER A 1 119 ? 31.820 77.430  16.175  1.00 37.59  ? 112 SER H CA  1 
ATOM   858  C C   . SER A 1 119 ? 30.957 76.625  15.208  1.00 37.02  ? 112 SER H C   1 
ATOM   859  O O   . SER A 1 119 ? 31.429 75.681  14.544  1.00 31.68  ? 112 SER H O   1 
ATOM   860  C CB  . SER A 1 119 ? 32.625 78.494  15.392  1.00 38.15  ? 112 SER H CB  1 
ATOM   861  O OG  . SER A 1 119 ? 31.868 79.681  15.099  1.00 39.28  ? 112 SER H OG  1 
ATOM   862  N N   . SER A 1 120 ? 29.682 76.995  15.162  1.00 37.50  ? 113 SER H N   1 
ATOM   863  C CA  . SER A 1 120 ? 28.811 76.569  14.076  1.00 38.21  ? 113 SER H CA  1 
ATOM   864  C C   . SER A 1 120 ? 28.530 77.673  13.027  1.00 38.75  ? 113 SER H C   1 
ATOM   865  O O   . SER A 1 120 ? 27.795 77.414  12.068  1.00 36.30  ? 113 SER H O   1 
ATOM   866  C CB  . SER A 1 120 ? 27.516 75.972  14.647  1.00 37.59  ? 113 SER H CB  1 
ATOM   867  O OG  . SER A 1 120 ? 27.731 74.604  14.940  1.00 35.95  ? 113 SER H OG  1 
ATOM   868  N N   . ALA A 1 121 ? 29.125 78.864  13.172  1.00 36.55  ? 114 ALA H N   1 
ATOM   869  C CA  . ALA A 1 121 ? 28.744 79.994  12.301  1.00 37.81  ? 114 ALA H CA  1 
ATOM   870  C C   . ALA A 1 121 ? 29.203 79.782  10.850  1.00 36.87  ? 114 ALA H C   1 
ATOM   871  O O   . ALA A 1 121 ? 30.143 79.047  10.559  1.00 33.00  ? 114 ALA H O   1 
ATOM   872  C CB  . ALA A 1 121 ? 29.222 81.345  12.836  1.00 35.61  ? 114 ALA H CB  1 
ATOM   873  N N   . SER A 1 122 ? 28.489 80.440  9.953   1.00 38.29  ? 115 SER H N   1 
ATOM   874  C CA  . SER A 1 122 ? 28.643 80.214  8.541   1.00 38.40  ? 115 SER H CA  1 
ATOM   875  C C   . SER A 1 122 ? 29.948 80.821  8.075   1.00 37.77  ? 115 SER H C   1 
ATOM   876  O O   . SER A 1 122 ? 30.318 81.901  8.505   1.00 41.61  ? 115 SER H O   1 
ATOM   877  C CB  . SER A 1 122 ? 27.482 80.857  7.784   1.00 36.21  ? 115 SER H CB  1 
ATOM   878  O OG  . SER A 1 122 ? 27.556 80.542  6.412   1.00 38.05  ? 115 SER H OG  1 
ATOM   879  N N   . THR A 1 123 ? 30.640 80.112  7.202   1.00 39.01  ? 116 THR H N   1 
ATOM   880  C CA  . THR A 1 123 ? 31.719 80.686  6.424   1.00 42.15  ? 116 THR H CA  1 
ATOM   881  C C   . THR A 1 123 ? 31.169 81.846  5.591   1.00 46.53  ? 116 THR H C   1 
ATOM   882  O O   . THR A 1 123 ? 30.032 81.750  5.089   1.00 54.64  ? 116 THR H O   1 
ATOM   883  C CB  . THR A 1 123 ? 32.314 79.638  5.490   1.00 41.71  ? 116 THR H CB  1 
ATOM   884  O OG1 . THR A 1 123 ? 32.924 78.604  6.269   1.00 41.43  ? 116 THR H OG1 1 
ATOM   885  C CG2 . THR A 1 123 ? 33.359 80.242  4.588   1.00 45.28  ? 116 THR H CG2 1 
ATOM   886  N N   . LYS A 1 124 ? 31.943 82.936  5.482   1.00 41.15  ? 117 LYS H N   1 
ATOM   887  C CA  . LYS A 1 124 ? 31.589 84.063  4.605   1.00 41.17  ? 117 LYS H CA  1 
ATOM   888  C C   . LYS A 1 124 ? 32.809 84.574  3.878   1.00 37.85  ? 117 LYS H C   1 
ATOM   889  O O   . LYS A 1 124 ? 33.794 84.930  4.504   1.00 35.15  ? 117 LYS H O   1 
ATOM   890  C CB  . LYS A 1 124 ? 30.941 85.218  5.374   1.00 44.28  ? 117 LYS H CB  1 
ATOM   891  C CG  . LYS A 1 124 ? 30.573 86.401  4.479   1.00 47.29  ? 117 LYS H CG  1 
ATOM   892  C CD  . LYS A 1 124 ? 30.156 87.612  5.281   1.00 52.96  ? 117 LYS H CD  1 
ATOM   893  C CE  . LYS A 1 124 ? 29.997 88.855  4.410   1.00 60.07  ? 117 LYS H CE  1 
ATOM   894  N NZ  . LYS A 1 124 ? 28.609 89.012  3.882   1.00 65.04  ? 117 LYS H NZ  1 
ATOM   895  N N   . GLY A 1 125 ? 32.721 84.623  2.555   1.00 34.90  ? 118 GLY H N   1 
ATOM   896  C CA  . GLY A 1 125 ? 33.785 85.180  1.717   1.00 35.73  ? 118 GLY H CA  1 
ATOM   897  C C   . GLY A 1 125 ? 33.898 86.712  1.850   1.00 35.41  ? 118 GLY H C   1 
ATOM   898  O O   . GLY A 1 125 ? 32.887 87.413  2.059   1.00 32.67  ? 118 GLY H O   1 
ATOM   899  N N   . PRO A 1 126 ? 35.128 87.251  1.767   1.00 33.51  ? 119 PRO H N   1 
ATOM   900  C CA  . PRO A 1 126 ? 35.244 88.701  1.857   1.00 34.74  ? 119 PRO H CA  1 
ATOM   901  C C   . PRO A 1 126 ? 34.717 89.454  0.628   1.00 35.89  ? 119 PRO H C   1 
ATOM   902  O O   . PRO A 1 126 ? 34.770 88.954  -0.517  1.00 35.38  ? 119 PRO H O   1 
ATOM   903  C CB  . PRO A 1 126 ? 36.749 88.926  2.025   1.00 35.09  ? 119 PRO H CB  1 
ATOM   904  C CG  . PRO A 1 126 ? 37.385 87.717  1.458   1.00 35.43  ? 119 PRO H CG  1 
ATOM   905  C CD  . PRO A 1 126 ? 36.440 86.593  1.759   1.00 36.02  ? 119 PRO H CD  1 
ATOM   906  N N   . SER A 1 127 ? 34.159 90.626  0.916   1.00 36.70  ? 120 SER H N   1 
ATOM   907  C CA  . SER A 1 127 ? 33.995 91.713  -0.042  1.00 36.29  ? 120 SER H CA  1 
ATOM   908  C C   . SER A 1 127 ? 35.286 92.495  -0.060  1.00 34.42  ? 120 SER H C   1 
ATOM   909  O O   . SER A 1 127 ? 35.755 92.911  1.000   1.00 41.61  ? 120 SER H O   1 
ATOM   910  C CB  . SER A 1 127 ? 32.897 92.642  0.421   1.00 38.01  ? 120 SER H CB  1 
ATOM   911  O OG  . SER A 1 127 ? 31.757 91.897  0.760   1.00 41.98  ? 120 SER H OG  1 
ATOM   912  N N   . VAL A 1 128 ? 35.839 92.715  -1.250  1.00 33.47  ? 121 VAL H N   1 
ATOM   913  C CA  . VAL A 1 128 ? 37.177 93.333  -1.442  1.00 31.30  ? 121 VAL H CA  1 
ATOM   914  C C   . VAL A 1 128 ? 37.081 94.675  -2.152  1.00 31.68  ? 121 VAL H C   1 
ATOM   915  O O   . VAL A 1 128 ? 36.700 94.715  -3.330  1.00 32.69  ? 121 VAL H O   1 
ATOM   916  C CB  . VAL A 1 128 ? 38.119 92.434  -2.272  1.00 29.25  ? 121 VAL H CB  1 
ATOM   917  C CG1 . VAL A 1 128 ? 39.481 93.100  -2.489  1.00 29.38  ? 121 VAL H CG1 1 
ATOM   918  C CG2 . VAL A 1 128 ? 38.314 91.095  -1.584  1.00 29.23  ? 121 VAL H CG2 1 
ATOM   919  N N   . PHE A 1 129 ? 37.497 95.749  -1.461  1.00 31.92  ? 122 PHE H N   1 
ATOM   920  C CA  . PHE A 1 129 ? 37.378 97.142  -1.958  1.00 29.88  ? 122 PHE H CA  1 
ATOM   921  C C   . PHE A 1 129 ? 38.725 97.844  -2.120  1.00 31.59  ? 122 PHE H C   1 
ATOM   922  O O   . PHE A 1 129 ? 39.581 97.750  -1.240  1.00 34.29  ? 122 PHE H O   1 
ATOM   923  C CB  . PHE A 1 129 ? 36.548 97.954  -1.005  1.00 28.95  ? 122 PHE H CB  1 
ATOM   924  C CG  . PHE A 1 129 ? 35.200 97.361  -0.741  1.00 31.59  ? 122 PHE H CG  1 
ATOM   925  C CD1 . PHE A 1 129 ? 34.258 97.301  -1.739  1.00 32.45  ? 122 PHE H CD1 1 
ATOM   926  C CD2 . PHE A 1 129 ? 34.880 96.849  0.503   1.00 33.05  ? 122 PHE H CD2 1 
ATOM   927  C CE1 . PHE A 1 129 ? 33.027 96.737  -1.508  1.00 33.68  ? 122 PHE H CE1 1 
ATOM   928  C CE2 . PHE A 1 129 ? 33.648 96.294  0.749   1.00 32.77  ? 122 PHE H CE2 1 
ATOM   929  C CZ  . PHE A 1 129 ? 32.720 96.242  -0.249  1.00 33.96  ? 122 PHE H CZ  1 
ATOM   930  N N   . PRO A 1 130 ? 38.916 98.573  -3.237  1.00 31.66  ? 123 PRO H N   1 
ATOM   931  C CA  . PRO A 1 130 ? 40.174 99.255  -3.398  1.00 31.94  ? 123 PRO H CA  1 
ATOM   932  C C   . PRO A 1 130 ? 40.294 100.432 -2.441  1.00 32.74  ? 123 PRO H C   1 
ATOM   933  O O   . PRO A 1 130 ? 39.302 101.098 -2.184  1.00 32.36  ? 123 PRO H O   1 
ATOM   934  C CB  . PRO A 1 130 ? 40.109 99.764  -4.853  1.00 32.95  ? 123 PRO H CB  1 
ATOM   935  C CG  . PRO A 1 130 ? 38.664 100.005 -5.093  1.00 31.44  ? 123 PRO H CG  1 
ATOM   936  C CD  . PRO A 1 130 ? 37.972 98.905  -4.328  1.00 32.50  ? 123 PRO H CD  1 
ATOM   937  N N   . LEU A 1 131 ? 41.504 100.624 -1.909  1.00 33.25  ? 124 LEU H N   1 
ATOM   938  C CA  . LEU A 1 131 ? 41.966 101.859 -1.272  1.00 31.97  ? 124 LEU H CA  1 
ATOM   939  C C   . LEU A 1 131 ? 42.886 102.596 -2.243  1.00 33.72  ? 124 LEU H C   1 
ATOM   940  O O   . LEU A 1 131 ? 44.113 102.349 -2.286  1.00 31.11  ? 124 LEU H O   1 
ATOM   941  C CB  . LEU A 1 131 ? 42.742 101.541 -0.006  1.00 32.37  ? 124 LEU H CB  1 
ATOM   942  C CG  . LEU A 1 131 ? 41.968 100.762 1.051   1.00 31.89  ? 124 LEU H CG  1 
ATOM   943  C CD1 . LEU A 1 131 ? 42.950 100.188 2.051   1.00 30.51  ? 124 LEU H CD1 1 
ATOM   944  C CD2 . LEU A 1 131 ? 40.949 101.683 1.712   1.00 31.78  ? 124 LEU H CD2 1 
ATOM   945  N N   . ALA A 1 132 ? 42.284 103.500 -3.019  1.00 33.55  ? 125 ALA H N   1 
ATOM   946  C CA  . ALA A 1 132 ? 42.942 104.077 -4.166  1.00 35.03  ? 125 ALA H CA  1 
ATOM   947  C C   . ALA A 1 132 ? 44.005 105.113 -3.792  1.00 35.57  ? 125 ALA H C   1 
ATOM   948  O O   . ALA A 1 132 ? 43.847 105.844 -2.822  1.00 33.72  ? 125 ALA H O   1 
ATOM   949  C CB  . ALA A 1 132 ? 41.934 104.711 -5.094  1.00 36.39  ? 125 ALA H CB  1 
ATOM   950  N N   . PRO A 1 133 ? 45.068 105.189 -4.602  1.00 36.20  ? 126 PRO H N   1 
ATOM   951  C CA  . PRO A 1 133 ? 46.056 106.215 -4.429  1.00 41.83  ? 126 PRO H CA  1 
ATOM   952  C C   . PRO A 1 133 ? 45.514 107.568 -4.912  1.00 43.56  ? 126 PRO H C   1 
ATOM   953  O O   . PRO A 1 133 ? 44.763 107.643 -5.908  1.00 46.02  ? 126 PRO H O   1 
ATOM   954  C CB  . PRO A 1 133 ? 47.229 105.724 -5.292  1.00 41.31  ? 126 PRO H CB  1 
ATOM   955  C CG  . PRO A 1 133 ? 46.594 104.928 -6.379  1.00 38.50  ? 126 PRO H CG  1 
ATOM   956  C CD  . PRO A 1 133 ? 45.293 104.421 -5.847  1.00 38.51  ? 126 PRO H CD  1 
ATOM   957  N N   . SER A 1 134 ? 45.890 108.612 -4.179  1.00 45.10  ? 127 SER H N   1 
ATOM   958  C CA  . SER A 1 134 ? 45.431 109.971 -4.429  1.00 43.89  ? 127 SER H CA  1 
ATOM   959  C C   . SER A 1 134 ? 46.470 110.880 -3.833  1.00 44.59  ? 127 SER H C   1 
ATOM   960  O O   . SER A 1 134 ? 47.408 110.398 -3.191  1.00 37.92  ? 127 SER H O   1 
ATOM   961  C CB  . SER A 1 134 ? 44.081 110.220 -3.750  1.00 42.06  ? 127 SER H CB  1 
ATOM   962  O OG  . SER A 1 134 ? 44.200 110.102 -2.341  1.00 43.62  ? 127 SER H OG  1 
ATOM   963  N N   . SER A 1 135 ? 46.272 112.185 -4.024  1.00 47.33  ? 128 SER H N   1 
ATOM   964  C CA  . SER A 1 135 ? 47.094 113.229 -3.378  1.00 50.27  ? 128 SER H CA  1 
ATOM   965  C C   . SER A 1 135 ? 47.219 113.109 -1.859  1.00 49.10  ? 128 SER H C   1 
ATOM   966  O O   . SER A 1 135 ? 48.246 113.489 -1.305  1.00 52.86  ? 128 SER H O   1 
ATOM   967  C CB  . SER A 1 135 ? 46.578 114.634 -3.727  1.00 52.26  ? 128 SER H CB  1 
ATOM   968  O OG  . SER A 1 135 ? 47.263 115.144 -4.859  1.00 54.98  ? 128 SER H OG  1 
ATOM   969  N N   . LYS A 1 136 ? 46.185 112.568 -1.210  1.00 50.94  ? 129 LYS H N   1 
ATOM   970  C CA  . LYS A 1 136 ? 46.139 112.335 0.261   1.00 49.60  ? 129 LYS H CA  1 
ATOM   971  C C   . LYS A 1 136 ? 46.774 111.008 0.757   1.00 44.62  ? 129 LYS H C   1 
ATOM   972  O O   . LYS A 1 136 ? 46.697 110.679 1.964   1.00 40.66  ? 129 LYS H O   1 
ATOM   973  C CB  . LYS A 1 136 ? 44.674 112.355 0.736   1.00 50.54  ? 129 LYS H CB  1 
ATOM   974  C CG  . LYS A 1 136 ? 43.888 113.599 0.375   1.00 52.27  ? 129 LYS H CG  1 
ATOM   975  C CD  . LYS A 1 136 ? 44.256 114.767 1.268   1.00 57.44  ? 129 LYS H CD  1 
ATOM   976  C CE  . LYS A 1 136 ? 43.846 116.097 0.648   1.00 61.85  ? 129 LYS H CE  1 
ATOM   977  N NZ  . LYS A 1 136 ? 42.364 116.244 0.537   1.00 65.65  ? 129 LYS H NZ  1 
ATOM   978  N N   . SER A 1 137 ? 47.331 110.241 -0.180  1.00 40.09  ? 130 SER H N   1 
ATOM   979  C CA  . SER A 1 137 ? 48.103 109.029 0.096   1.00 40.25  ? 130 SER H CA  1 
ATOM   980  C C   . SER A 1 137 ? 49.500 109.090 -0.526  1.00 44.40  ? 130 SER H C   1 
ATOM   981  O O   . SER A 1 137 ? 50.060 108.056 -0.899  1.00 43.62  ? 130 SER H O   1 
ATOM   982  C CB  . SER A 1 137 ? 47.382 107.809 -0.471  1.00 38.80  ? 130 SER H CB  1 
ATOM   983  O OG  . SER A 1 137 ? 47.606 107.698 -1.869  1.00 36.77  ? 130 SER H OG  1 
ATOM   984  N N   . THR A 1 138 ? 50.049 110.296 -0.645  1.00 47.07  ? 131 THR H N   1 
ATOM   985  C CA  . THR A 1 138 ? 51.331 110.513 -1.294  1.00 51.88  ? 131 THR H CA  1 
ATOM   986  C C   . THR A 1 138 ? 52.330 111.191 -0.336  1.00 56.27  ? 131 THR H C   1 
ATOM   987  O O   . THR A 1 138 ? 51.997 112.159 0.359   1.00 50.28  ? 131 THR H O   1 
ATOM   988  C CB  . THR A 1 138 ? 51.152 111.329 -2.588  1.00 53.32  ? 131 THR H CB  1 
ATOM   989  O OG1 . THR A 1 138 ? 50.456 110.530 -3.551  1.00 53.57  ? 131 THR H OG1 1 
ATOM   990  C CG2 . THR A 1 138 ? 52.483 111.751 -3.172  1.00 53.96  ? 131 THR H CG2 1 
ATOM   991  N N   . SER A 1 139 ? 53.558 110.669 -0.321  1.00 59.17  ? 132 SER H N   1 
ATOM   992  C CA  . SER A 1 139 ? 54.613 111.179 0.546   1.00 62.13  ? 132 SER H CA  1 
ATOM   993  C C   . SER A 1 139 ? 55.865 111.497 -0.247  1.00 65.10  ? 132 SER H C   1 
ATOM   994  O O   . SER A 1 139 ? 56.884 110.808 -0.132  1.00 70.02  ? 132 SER H O   1 
ATOM   995  C CB  . SER A 1 139 ? 54.933 110.180 1.652   1.00 62.78  ? 132 SER H CB  1 
ATOM   996  O OG  . SER A 1 139 ? 55.982 110.655 2.487   1.00 63.28  ? 132 SER H OG  1 
ATOM   997  N N   . GLY A 1 140 ? 55.762 112.552 -1.050  1.00 65.28  ? 133 GLY H N   1 
ATOM   998  C CA  . GLY A 1 140 ? 56.874 113.084 -1.826  1.00 65.09  ? 133 GLY H CA  1 
ATOM   999  C C   . GLY A 1 140 ? 57.688 112.032 -2.548  1.00 63.48  ? 133 GLY H C   1 
ATOM   1000 O O   . GLY A 1 140 ? 58.800 111.704 -2.125  1.00 65.01  ? 133 GLY H O   1 
ATOM   1001 N N   . GLY A 1 141 ? 57.126 111.515 -3.637  1.00 58.72  ? 134 GLY H N   1 
ATOM   1002 C CA  . GLY A 1 141 ? 57.775 110.482 -4.440  1.00 56.04  ? 134 GLY H CA  1 
ATOM   1003 C C   . GLY A 1 141 ? 56.981 109.184 -4.484  1.00 55.62  ? 134 GLY H C   1 
ATOM   1004 O O   . GLY A 1 141 ? 56.953 108.482 -5.512  1.00 56.07  ? 134 GLY H O   1 
ATOM   1005 N N   . THR A 1 142 ? 56.316 108.873 -3.381  1.00 49.38  ? 135 THR H N   1 
ATOM   1006 C CA  . THR A 1 142 ? 55.644 107.605 -3.238  1.00 47.16  ? 135 THR H CA  1 
ATOM   1007 C C   . THR A 1 142 ? 54.159 107.747 -3.023  1.00 44.41  ? 135 THR H C   1 
ATOM   1008 O O   . THR A 1 142 ? 53.700 108.655 -2.351  1.00 45.79  ? 135 THR H O   1 
ATOM   1009 C CB  . THR A 1 142 ? 56.207 106.831 -2.047  1.00 47.14  ? 135 THR H CB  1 
ATOM   1010 O OG1 . THR A 1 142 ? 56.086 107.627 -0.865  1.00 43.69  ? 135 THR H OG1 1 
ATOM   1011 C CG2 . THR A 1 142 ? 57.653 106.531 -2.286  1.00 48.61  ? 135 THR H CG2 1 
ATOM   1012 N N   . ALA A 1 143 ? 53.422 106.820 -3.604  1.00 39.78  ? 136 ALA H N   1 
ATOM   1013 C CA  . ALA A 1 143 ? 52.017 106.703 -3.359  1.00 39.61  ? 136 ALA H CA  1 
ATOM   1014 C C   . ALA A 1 143 ? 51.756 105.446 -2.521  1.00 38.32  ? 136 ALA H C   1 
ATOM   1015 O O   . ALA A 1 143 ? 52.369 104.380 -2.757  1.00 35.22  ? 136 ALA H O   1 
ATOM   1016 C CB  . ALA A 1 143 ? 51.267 106.632 -4.677  1.00 38.87  ? 136 ALA H CB  1 
ATOM   1017 N N   . ALA A 1 144 ? 50.844 105.590 -1.556  1.00 34.48  ? 137 ALA H N   1 
ATOM   1018 C CA  . ALA A 1 144 ? 50.292 104.467 -0.817  1.00 32.18  ? 137 ALA H CA  1 
ATOM   1019 C C   . ALA A 1 144 ? 48.955 104.065 -1.388  1.00 30.48  ? 137 ALA H C   1 
ATOM   1020 O O   . ALA A 1 144 ? 48.151 104.909 -1.784  1.00 31.00  ? 137 ALA H O   1 
ATOM   1021 C CB  . ALA A 1 144 ? 50.155 104.790 0.668   1.00 31.58  ? 137 ALA H CB  1 
ATOM   1022 N N   . LEU A 1 145 ? 48.714 102.757 -1.407  1.00 30.67  ? 138 LEU H N   1 
ATOM   1023 C CA  . LEU A 1 145 ? 47.432 102.200 -1.835  1.00 31.24  ? 138 LEU H CA  1 
ATOM   1024 C C   . LEU A 1 145 ? 47.225 100.840 -1.234  1.00 30.41  ? 138 LEU H C   1 
ATOM   1025 O O   . LEU A 1 145 ? 48.158 100.179 -0.803  1.00 29.94  ? 138 LEU H O   1 
ATOM   1026 C CB  . LEU A 1 145 ? 47.398 102.049 -3.339  1.00 33.59  ? 138 LEU H CB  1 
ATOM   1027 C CG  . LEU A 1 145 ? 48.490 101.149 -3.944  1.00 34.79  ? 138 LEU H CG  1 
ATOM   1028 C CD1 . LEU A 1 145 ? 48.000 99.749  -4.227  1.00 36.92  ? 138 LEU H CD1 1 
ATOM   1029 C CD2 . LEU A 1 145 ? 49.037 101.744 -5.237  1.00 37.51  ? 138 LEU H CD2 1 
ATOM   1030 N N   . GLY A 1 146 ? 45.993 100.385 -1.294  1.00 29.66  ? 139 GLY H N   1 
ATOM   1031 C CA  . GLY A 1 146 ? 45.671 99.113  -0.728  1.00 29.20  ? 139 GLY H CA  1 
ATOM   1032 C C   . GLY A 1 146 ? 44.327 98.531  -1.107  1.00 28.66  ? 139 GLY H C   1 
ATOM   1033 O O   . GLY A 1 146 ? 43.676 98.983  -2.070  1.00 29.32  ? 139 GLY H O   1 
ATOM   1034 N N   . CYS A 1 147 ? 43.964 97.494  -0.353  1.00 25.46  ? 140 CYS H N   1 
ATOM   1035 C CA  . CYS A 1 147 ? 42.698 96.820  -0.493  1.00 29.17  ? 140 CYS H CA  1 
ATOM   1036 C C   . CYS A 1 147 ? 42.162 96.563  0.884   1.00 28.31  ? 140 CYS H C   1 
ATOM   1037 O O   . CYS A 1 147 ? 42.911 96.162  1.768   1.00 29.17  ? 140 CYS H O   1 
ATOM   1038 C CB  . CYS A 1 147 ? 42.846 95.504  -1.257  1.00 29.64  ? 140 CYS H CB  1 
ATOM   1039 S SG  . CYS A 1 147 ? 43.044 95.756  -3.043  1.00 35.23  ? 140 CYS H SG  1 
ATOM   1040 N N   . LEU A 1 148 ? 40.871 96.850  1.061   1.00 29.94  ? 141 LEU H N   1 
ATOM   1041 C CA  . LEU A 1 148 ? 40.151 96.571  2.306   1.00 28.40  ? 141 LEU H CA  1 
ATOM   1042 C C   . LEU A 1 148 ? 39.427 95.229  2.115   1.00 28.06  ? 141 LEU H C   1 
ATOM   1043 O O   . LEU A 1 148 ? 38.579 95.075  1.217   1.00 30.96  ? 141 LEU H O   1 
ATOM   1044 C CB  . LEU A 1 148 ? 39.167 97.712  2.658   1.00 25.92  ? 141 LEU H CB  1 
ATOM   1045 C CG  . LEU A 1 148 ? 38.242 97.473  3.868   1.00 24.58  ? 141 LEU H CG  1 
ATOM   1046 C CD1 . LEU A 1 148 ? 38.905 97.756  5.215   1.00 23.87  ? 141 LEU H CD1 1 
ATOM   1047 C CD2 . LEU A 1 148 ? 36.938 98.228  3.734   1.00 25.31  ? 141 LEU H CD2 1 
ATOM   1048 N N   . VAL A 1 149 ? 39.764 94.287  2.979   1.00 29.19  ? 142 VAL H N   1 
ATOM   1049 C CA  . VAL A 1 149 ? 39.286 92.914  2.919   1.00 29.76  ? 142 VAL H CA  1 
ATOM   1050 C C   . VAL A 1 149 ? 38.349 92.720  4.120   1.00 33.38  ? 142 VAL H C   1 
ATOM   1051 O O   . VAL A 1 149 ? 38.788 92.422  5.235   1.00 29.98  ? 142 VAL H O   1 
ATOM   1052 C CB  . VAL A 1 149 ? 40.464 91.934  2.915   1.00 28.70  ? 142 VAL H CB  1 
ATOM   1053 C CG1 . VAL A 1 149 ? 39.960 90.510  2.850   1.00 28.74  ? 142 VAL H CG1 1 
ATOM   1054 C CG2 . VAL A 1 149 ? 41.355 92.196  1.710   1.00 29.36  ? 142 VAL H CG2 1 
ATOM   1055 N N   . LYS A 1 150 ? 37.053 92.895  3.840   1.00 37.13  ? 143 LYS H N   1 
ATOM   1056 C CA  . LYS A 1 150 ? 36.030 93.197  4.827   1.00 38.54  ? 143 LYS H CA  1 
ATOM   1057 C C   . LYS A 1 150 ? 34.953 92.127  4.878   1.00 39.72  ? 143 LYS H C   1 
ATOM   1058 O O   . LYS A 1 150 ? 34.497 91.639  3.823   1.00 40.13  ? 143 LYS H O   1 
ATOM   1059 C CB  . LYS A 1 150 ? 35.369 94.530  4.473   1.00 40.27  ? 143 LYS H CB  1 
ATOM   1060 C CG  . LYS A 1 150 ? 34.437 95.060  5.532   1.00 40.52  ? 143 LYS H CG  1 
ATOM   1061 C CD  . LYS A 1 150 ? 33.759 96.347  5.097   1.00 43.55  ? 143 LYS H CD  1 
ATOM   1062 C CE  . LYS A 1 150 ? 32.707 96.786  6.105   1.00 44.02  ? 143 LYS H CE  1 
ATOM   1063 N NZ  . LYS A 1 150 ? 33.330 97.239  7.378   1.00 47.79  ? 143 LYS H NZ  1 
ATOM   1064 N N   . ASP A 1 151 ? 34.547 91.805  6.114   1.00 36.51  ? 144 ASP H N   1 
ATOM   1065 C CA  . ASP A 1 151 ? 33.404 90.934  6.420   1.00 37.06  ? 144 ASP H CA  1 
ATOM   1066 C C   . ASP A 1 151 ? 33.591 89.521  5.867   1.00 38.14  ? 144 ASP H C   1 
ATOM   1067 O O   . ASP A 1 151 ? 32.866 89.072  4.986   1.00 34.44  ? 144 ASP H O   1 
ATOM   1068 C CB  . ASP A 1 151 ? 32.072 91.566  5.945   1.00 36.62  ? 144 ASP H CB  1 
ATOM   1069 C CG  . ASP A 1 151 ? 31.758 92.871  6.650   1.00 36.07  ? 144 ASP H CG  1 
ATOM   1070 O OD1 . ASP A 1 151 ? 32.371 93.167  7.692   1.00 39.27  ? 144 ASP H OD1 1 
ATOM   1071 O OD2 . ASP A 1 151 ? 30.897 93.618  6.168   1.00 39.11  ? 144 ASP H OD2 1 
ATOM   1072 N N   . TYR A 1 152 ? 34.612 88.851  6.394   1.00 42.06  ? 145 TYR H N   1 
ATOM   1073 C CA  . TYR A 1 152 ? 34.846 87.439  6.138   1.00 40.19  ? 145 TYR H CA  1 
ATOM   1074 C C   . TYR A 1 152 ? 34.866 86.629  7.446   1.00 41.27  ? 145 TYR H C   1 
ATOM   1075 O O   . TYR A 1 152 ? 34.995 87.166  8.554   1.00 36.27  ? 145 TYR H O   1 
ATOM   1076 C CB  . TYR A 1 152 ? 36.133 87.203  5.326   1.00 39.67  ? 145 TYR H CB  1 
ATOM   1077 C CG  . TYR A 1 152 ? 37.429 87.513  6.055   1.00 38.77  ? 145 TYR H CG  1 
ATOM   1078 C CD1 . TYR A 1 152 ? 37.952 88.792  6.051   1.00 35.31  ? 145 TYR H CD1 1 
ATOM   1079 C CD2 . TYR A 1 152 ? 38.117 86.522  6.759   1.00 38.83  ? 145 TYR H CD2 1 
ATOM   1080 C CE1 . TYR A 1 152 ? 39.113 89.082  6.718   1.00 34.74  ? 145 TYR H CE1 1 
ATOM   1081 C CE2 . TYR A 1 152 ? 39.293 86.803  7.430   1.00 36.79  ? 145 TYR H CE2 1 
ATOM   1082 C CZ  . TYR A 1 152 ? 39.790 88.089  7.403   1.00 34.74  ? 145 TYR H CZ  1 
ATOM   1083 O OH  . TYR A 1 152 ? 40.965 88.408  8.049   1.00 32.27  ? 145 TYR H OH  1 
ATOM   1084 N N   . PHE A 1 153 ? 34.734 85.321  7.270   1.00 40.23  ? 146 PHE H N   1 
ATOM   1085 C CA  . PHE A 1 153 ? 34.811 84.370  8.348   1.00 39.72  ? 146 PHE H CA  1 
ATOM   1086 C C   . PHE A 1 153 ? 35.003 82.960  7.745   1.00 38.23  ? 146 PHE H C   1 
ATOM   1087 O O   . PHE A 1 153 ? 34.324 82.628  6.777   1.00 35.72  ? 146 PHE H O   1 
ATOM   1088 C CB  . PHE A 1 153 ? 33.518 84.404  9.175   1.00 40.73  ? 146 PHE H CB  1 
ATOM   1089 C CG  . PHE A 1 153 ? 33.573 83.542  10.399  1.00 43.28  ? 146 PHE H CG  1 
ATOM   1090 C CD1 . PHE A 1 153 ? 33.262 82.183  10.329  1.00 46.73  ? 146 PHE H CD1 1 
ATOM   1091 C CD2 . PHE A 1 153 ? 33.968 84.070  11.615  1.00 46.18  ? 146 PHE H CD2 1 
ATOM   1092 C CE1 . PHE A 1 153 ? 33.334 81.371  11.456  1.00 48.22  ? 146 PHE H CE1 1 
ATOM   1093 C CE2 . PHE A 1 153 ? 34.032 83.267  12.747  1.00 47.75  ? 146 PHE H CE2 1 
ATOM   1094 C CZ  . PHE A 1 153 ? 33.722 81.913  12.665  1.00 49.87  ? 146 PHE H CZ  1 
ATOM   1095 N N   . PRO A 1 154 ? 35.877 82.114  8.332   1.00 36.53  ? 147 PRO H N   1 
ATOM   1096 C CA  . PRO A 1 154 ? 36.758 82.389  9.447   1.00 34.96  ? 147 PRO H CA  1 
ATOM   1097 C C   . PRO A 1 154 ? 38.078 82.915  8.907   1.00 37.82  ? 147 PRO H C   1 
ATOM   1098 O O   . PRO A 1 154 ? 38.180 83.195  7.702   1.00 36.38  ? 147 PRO H O   1 
ATOM   1099 C CB  . PRO A 1 154 ? 36.933 81.011  10.078  1.00 34.23  ? 147 PRO H CB  1 
ATOM   1100 C CG  . PRO A 1 154 ? 36.911 80.081  8.907   1.00 34.70  ? 147 PRO H CG  1 
ATOM   1101 C CD  . PRO A 1 154 ? 35.913 80.680  7.961   1.00 35.45  ? 147 PRO H CD  1 
ATOM   1102 N N   . GLU A 1 155 ? 39.074 83.029  9.793   1.00 38.74  ? 148 GLU H N   1 
ATOM   1103 C CA  . GLU A 1 155 ? 40.465 83.235  9.399   1.00 39.61  ? 148 GLU H CA  1 
ATOM   1104 C C   . GLU A 1 155 ? 40.930 82.012  8.635   1.00 37.56  ? 148 GLU H C   1 
ATOM   1105 O O   . GLU A 1 155 ? 40.382 80.946  8.854   1.00 34.24  ? 148 GLU H O   1 
ATOM   1106 C CB  . GLU A 1 155 ? 41.373 83.395  10.625  1.00 42.39  ? 148 GLU H CB  1 
ATOM   1107 C CG  . GLU A 1 155 ? 41.176 84.689  11.398  1.00 45.11  ? 148 GLU H CG  1 
ATOM   1108 C CD  . GLU A 1 155 ? 42.246 85.725  11.125  1.00 47.02  ? 148 GLU H CD  1 
ATOM   1109 O OE1 . GLU A 1 155 ? 42.789 86.233  12.138  1.00 41.74  ? 148 GLU H OE1 1 
ATOM   1110 O OE2 . GLU A 1 155 ? 42.526 86.020  9.920   1.00 48.03  ? 148 GLU H OE2 1 
ATOM   1111 N N   . PRO A 1 156 ? 41.946 82.150  7.763   1.00 35.74  ? 149 PRO H N   1 
ATOM   1112 C CA  . PRO A 1 156 ? 42.625 83.388  7.425   1.00 35.64  ? 149 PRO H CA  1 
ATOM   1113 C C   . PRO A 1 156 ? 42.304 83.848  6.020   1.00 34.99  ? 149 PRO H C   1 
ATOM   1114 O O   . PRO A 1 156 ? 41.735 83.101  5.258   1.00 35.40  ? 149 PRO H O   1 
ATOM   1115 C CB  . PRO A 1 156 ? 44.096 82.983  7.501   1.00 35.29  ? 149 PRO H CB  1 
ATOM   1116 C CG  . PRO A 1 156 ? 44.123 81.521  7.136   1.00 33.72  ? 149 PRO H CG  1 
ATOM   1117 C CD  . PRO A 1 156 ? 42.721 80.986  7.279   1.00 34.52  ? 149 PRO H CD  1 
ATOM   1118 N N   . VAL A 1 157 ? 42.674 85.079  5.695   1.00 35.66  ? 150 VAL H N   1 
ATOM   1119 C CA  . VAL A 1 157 ? 42.882 85.457  4.285   1.00 35.59  ? 150 VAL H CA  1 
ATOM   1120 C C   . VAL A 1 157 ? 44.376 85.569  3.963   1.00 37.35  ? 150 VAL H C   1 
ATOM   1121 O O   . VAL A 1 157 ? 45.230 85.641  4.854   1.00 38.85  ? 150 VAL H O   1 
ATOM   1122 C CB  . VAL A 1 157 ? 42.167 86.755  3.882   1.00 35.59  ? 150 VAL H CB  1 
ATOM   1123 C CG1 . VAL A 1 157 ? 40.670 86.558  3.952   1.00 35.81  ? 150 VAL H CG1 1 
ATOM   1124 C CG2 . VAL A 1 157 ? 42.602 87.941  4.742   1.00 36.98  ? 150 VAL H CG2 1 
ATOM   1125 N N   . THR A 1 158 ? 44.671 85.545  2.670   1.00 40.47  ? 151 THR H N   1 
ATOM   1126 C CA  . THR A 1 158 ? 45.977 85.919  2.147   1.00 41.78  ? 151 THR H CA  1 
ATOM   1127 C C   . THR A 1 158 ? 45.808 86.986  1.063   1.00 38.48  ? 151 THR H C   1 
ATOM   1128 O O   . THR A 1 158 ? 45.069 86.812  0.109   1.00 38.30  ? 151 THR H O   1 
ATOM   1129 C CB  . THR A 1 158 ? 46.753 84.711  1.584   1.00 45.28  ? 151 THR H CB  1 
ATOM   1130 O OG1 . THR A 1 158 ? 45.997 84.080  0.545   1.00 50.85  ? 151 THR H OG1 1 
ATOM   1131 C CG2 . THR A 1 158 ? 47.042 83.698  2.693   1.00 47.32  ? 151 THR H CG2 1 
ATOM   1132 N N   . VAL A 1 159 ? 46.482 88.106  1.237   1.00 35.41  ? 152 VAL H N   1 
ATOM   1133 C CA  . VAL A 1 159 ? 46.559 89.120  0.205   1.00 33.99  ? 152 VAL H CA  1 
ATOM   1134 C C   . VAL A 1 159 ? 47.919 89.016  -0.453  1.00 34.04  ? 152 VAL H C   1 
ATOM   1135 O O   . VAL A 1 159 ? 48.924 88.768  0.212   1.00 32.56  ? 152 VAL H O   1 
ATOM   1136 C CB  . VAL A 1 159 ? 46.368 90.530  0.799   1.00 34.50  ? 152 VAL H CB  1 
ATOM   1137 C CG1 . VAL A 1 159 ? 46.476 91.602  -0.278  1.00 32.82  ? 152 VAL H CG1 1 
ATOM   1138 C CG2 . VAL A 1 159 ? 44.986 90.620  1.450   1.00 36.52  ? 152 VAL H CG2 1 
ATOM   1139 N N   . SER A 1 160 ? 47.975 89.195  -1.761  1.00 34.31  ? 153 SER H N   1 
ATOM   1140 C CA  . SER A 1 160 ? 49.282 89.415  -2.390  1.00 35.99  ? 153 SER H CA  1 
ATOM   1141 C C   . SER A 1 160 ? 49.179 90.442  -3.497  1.00 33.90  ? 153 SER H C   1 
ATOM   1142 O O   . SER A 1 160 ? 48.128 90.638  -4.090  1.00 34.21  ? 153 SER H O   1 
ATOM   1143 C CB  . SER A 1 160 ? 49.914 88.109  -2.866  1.00 35.27  ? 153 SER H CB  1 
ATOM   1144 O OG  . SER A 1 160 ? 49.176 87.575  -3.933  1.00 36.09  ? 153 SER H OG  1 
ATOM   1145 N N   . TRP A 1 161 ? 50.289 91.112  -3.744  1.00 35.82  ? 154 TRP H N   1 
ATOM   1146 C CA  . TRP A 1 161 ? 50.333 92.217  -4.688  1.00 36.92  ? 154 TRP H CA  1 
ATOM   1147 C C   . TRP A 1 161 ? 51.121 91.845  -5.898  1.00 37.93  ? 154 TRP H C   1 
ATOM   1148 O O   . TRP A 1 161 ? 51.873 90.878  -5.890  1.00 34.83  ? 154 TRP H O   1 
ATOM   1149 C CB  . TRP A 1 161 ? 50.972 93.423  -4.040  1.00 36.70  ? 154 TRP H CB  1 
ATOM   1150 C CG  . TRP A 1 161 ? 50.095 93.968  -3.013  1.00 37.17  ? 154 TRP H CG  1 
ATOM   1151 C CD1 . TRP A 1 161 ? 50.100 93.658  -1.699  1.00 36.30  ? 154 TRP H CD1 1 
ATOM   1152 C CD2 . TRP A 1 161 ? 49.020 94.877  -3.220  1.00 35.45  ? 154 TRP H CD2 1 
ATOM   1153 N NE1 . TRP A 1 161 ? 49.104 94.338  -1.054  1.00 38.02  ? 154 TRP H NE1 1 
ATOM   1154 C CE2 . TRP A 1 161 ? 48.419 95.093  -1.967  1.00 35.65  ? 154 TRP H CE2 1 
ATOM   1155 C CE3 . TRP A 1 161 ? 48.507 95.538  -4.347  1.00 34.55  ? 154 TRP H CE3 1 
ATOM   1156 C CZ2 . TRP A 1 161 ? 47.335 95.947  -1.799  1.00 34.31  ? 154 TRP H CZ2 1 
ATOM   1157 C CZ3 . TRP A 1 161 ? 47.445 96.390  -4.186  1.00 34.77  ? 154 TRP H CZ3 1 
ATOM   1158 C CH2 . TRP A 1 161 ? 46.868 96.597  -2.919  1.00 34.62  ? 154 TRP H CH2 1 
ATOM   1159 N N   . ASN A 1 162 ? 50.958 92.651  -6.933  1.00 39.91  ? 155 ASN H N   1 
ATOM   1160 C CA  . ASN A 1 162 ? 51.644 92.412  -8.198  1.00 41.43  ? 155 ASN H CA  1 
ATOM   1161 C C   . ASN A 1 162 ? 52.852 93.355  -8.343  1.00 44.97  ? 155 ASN H C   1 
ATOM   1162 O O   . ASN A 1 162 ? 53.208 94.050  -7.399  1.00 37.04  ? 155 ASN H O   1 
ATOM   1163 C CB  . ASN A 1 162 ? 50.640 92.520  -9.343  1.00 41.02  ? 155 ASN H CB  1 
ATOM   1164 C CG  . ASN A 1 162 ? 50.077 93.919  -9.514  1.00 40.32  ? 155 ASN H CG  1 
ATOM   1165 O OD1 . ASN A 1 162 ? 50.091 94.740  -8.593  1.00 36.01  ? 155 ASN H OD1 1 
ATOM   1166 N ND2 . ASN A 1 162 ? 49.555 94.188  -10.702 1.00 41.35  ? 155 ASN H ND2 1 
ATOM   1167 N N   . SER A 1 163 ? 53.504 93.335  -9.502  1.00 50.79  ? 156 SER H N   1 
ATOM   1168 C CA  . SER A 1 163 ? 54.684 94.181  -9.780  1.00 55.96  ? 156 SER H CA  1 
ATOM   1169 C C   . SER A 1 163 ? 55.985 93.771  -9.027  1.00 58.01  ? 156 SER H C   1 
ATOM   1170 O O   . SER A 1 163 ? 56.944 94.568  -8.938  1.00 50.26  ? 156 SER H O   1 
ATOM   1171 C CB  . SER A 1 163 ? 54.360 95.658  -9.509  1.00 59.54  ? 156 SER H CB  1 
ATOM   1172 O OG  . SER A 1 163 ? 55.157 96.530  -10.315 1.00 63.27  ? 156 SER H OG  1 
ATOM   1173 N N   . GLY A 1 164 ? 56.002 92.545  -8.487  1.00 65.85  ? 157 GLY H N   1 
ATOM   1174 C CA  . GLY A 1 164 ? 57.194 91.954  -7.846  1.00 67.76  ? 157 GLY H CA  1 
ATOM   1175 C C   . GLY A 1 164 ? 57.949 92.765  -6.792  1.00 70.02  ? 157 GLY H C   1 
ATOM   1176 O O   . GLY A 1 164 ? 57.468 92.962  -5.677  1.00 63.07  ? 157 GLY H O   1 
ATOM   1177 N N   . ALA A 1 165 ? 59.144 93.229  -7.160  1.00 75.38  ? 158 ALA H N   1 
ATOM   1178 C CA  . ALA A 1 165 ? 60.116 93.767  -6.195  1.00 81.25  ? 158 ALA H CA  1 
ATOM   1179 C C   . ALA A 1 165 ? 59.639 95.048  -5.532  1.00 82.68  ? 158 ALA H C   1 
ATOM   1180 O O   . ALA A 1 165 ? 59.669 95.158  -4.295  1.00 76.72  ? 158 ALA H O   1 
ATOM   1181 C CB  . ALA A 1 165 ? 61.476 93.992  -6.852  1.00 80.29  ? 158 ALA H CB  1 
ATOM   1182 N N   . LEU A 1 166 ? 59.182 96.000  -6.345  1.00 84.00  ? 159 LEU H N   1 
ATOM   1183 C CA  . LEU A 1 166 ? 58.738 97.286  -5.805  1.00 90.94  ? 159 LEU H CA  1 
ATOM   1184 C C   . LEU A 1 166 ? 57.446 97.198  -4.956  1.00 93.25  ? 159 LEU H C   1 
ATOM   1185 O O   . LEU A 1 166 ? 57.153 98.128  -4.196  1.00 93.06  ? 159 LEU H O   1 
ATOM   1186 C CB  . LEU A 1 166 ? 58.655 98.374  -6.899  1.00 92.80  ? 159 LEU H CB  1 
ATOM   1187 C CG  . LEU A 1 166 ? 57.717 98.276  -8.107  1.00 95.45  ? 159 LEU H CG  1 
ATOM   1188 C CD1 . LEU A 1 166 ? 56.299 98.630  -7.711  1.00 100.49 ? 159 LEU H CD1 1 
ATOM   1189 C CD2 . LEU A 1 166 ? 58.154 99.207  -9.230  1.00 91.89  ? 159 LEU H CD2 1 
ATOM   1190 N N   . THR A 1 167 ? 56.690 96.099  -5.059  1.00 91.20  ? 160 THR H N   1 
ATOM   1191 C CA  . THR A 1 167 ? 55.477 95.958  -4.241  1.00 84.91  ? 160 THR H CA  1 
ATOM   1192 C C   . THR A 1 167 ? 55.685 95.404  -2.832  1.00 86.99  ? 160 THR H C   1 
ATOM   1193 O O   . THR A 1 167 ? 54.729 95.365  -2.061  1.00 88.86  ? 160 THR H O   1 
ATOM   1194 C CB  . THR A 1 167 ? 54.347 95.181  -4.950  1.00 78.96  ? 160 THR H CB  1 
ATOM   1195 O OG1 . THR A 1 167 ? 53.108 95.519  -4.332  1.00 77.89  ? 160 THR H OG1 1 
ATOM   1196 C CG2 . THR A 1 167 ? 54.524 93.650  -4.907  1.00 78.37  ? 160 THR H CG2 1 
ATOM   1197 N N   . SER A 1 168 ? 56.894 94.965  -2.485  1.00 83.91  ? 161 SER H N   1 
ATOM   1198 C CA  . SER A 1 168 ? 57.155 94.620  -1.088  1.00 84.06  ? 161 SER H CA  1 
ATOM   1199 C C   . SER A 1 168 ? 57.249 95.916  -0.261  1.00 77.71  ? 161 SER H C   1 
ATOM   1200 O O   . SER A 1 168 ? 57.140 97.021  -0.812  1.00 82.39  ? 161 SER H O   1 
ATOM   1201 C CB  . SER A 1 168 ? 58.384 93.741  -0.929  1.00 85.75  ? 161 SER H CB  1 
ATOM   1202 O OG  . SER A 1 168 ? 58.369 93.192  0.378   1.00 91.69  ? 161 SER H OG  1 
ATOM   1203 N N   . GLY A 1 169 ? 57.471 95.785  1.044   1.00 70.69  ? 162 GLY H N   1 
ATOM   1204 C CA  . GLY A 1 169 ? 57.071 96.836  1.999   1.00 65.79  ? 162 GLY H CA  1 
ATOM   1205 C C   . GLY A 1 169 ? 55.557 96.819  2.144   1.00 58.61  ? 162 GLY H C   1 
ATOM   1206 O O   . GLY A 1 169 ? 54.933 97.834  2.449   1.00 62.94  ? 162 GLY H O   1 
ATOM   1207 N N   . VAL A 1 170 ? 54.982 95.638  1.910   1.00 53.50  ? 163 VAL H N   1 
ATOM   1208 C CA  . VAL A 1 170 ? 53.560 95.401  2.067   1.00 48.07  ? 163 VAL H CA  1 
ATOM   1209 C C   . VAL A 1 170 ? 53.334 95.409  3.567   1.00 43.68  ? 163 VAL H C   1 
ATOM   1210 O O   . VAL A 1 170 ? 54.178 94.919  4.335   1.00 35.56  ? 163 VAL H O   1 
ATOM   1211 C CB  . VAL A 1 170 ? 53.052 94.014  1.568   1.00 48.92  ? 163 VAL H CB  1 
ATOM   1212 C CG1 . VAL A 1 170 ? 51.560 94.087  1.275   1.00 48.72  ? 163 VAL H CG1 1 
ATOM   1213 C CG2 . VAL A 1 170 ? 53.786 93.477  0.348   1.00 52.05  ? 163 VAL H CG2 1 
ATOM   1214 N N   . HIS A 1 171 ? 52.190 95.952  3.966   1.00 41.30  ? 164 HIS H N   1 
ATOM   1215 C CA  . HIS A 1 171 ? 51.710 95.818  5.337   1.00 39.69  ? 164 HIS H CA  1 
ATOM   1216 C C   . HIS A 1 171 ? 50.307 95.249  5.255   1.00 40.41  ? 164 HIS H C   1 
ATOM   1217 O O   . HIS A 1 171 ? 49.326 95.982  5.030   1.00 35.40  ? 164 HIS H O   1 
ATOM   1218 C CB  . HIS A 1 171 ? 51.703 97.154  6.095   1.00 39.68  ? 164 HIS H CB  1 
ATOM   1219 C CG  . HIS A 1 171 ? 53.049 97.789  6.228   1.00 41.15  ? 164 HIS H CG  1 
ATOM   1220 N ND1 . HIS A 1 171 ? 54.160 97.110  6.686   1.00 44.98  ? 164 HIS H ND1 1 
ATOM   1221 C CD2 . HIS A 1 171 ? 53.459 99.051  5.976   1.00 43.81  ? 164 HIS H CD2 1 
ATOM   1222 C CE1 . HIS A 1 171 ? 55.198 97.925  6.702   1.00 43.17  ? 164 HIS H CE1 1 
ATOM   1223 N NE2 . HIS A 1 171 ? 54.798 99.110  6.281   1.00 42.74  ? 164 HIS H NE2 1 
ATOM   1224 N N   . THR A 1 172 ? 50.230 93.928  5.408   1.00 37.28  ? 165 THR H N   1 
ATOM   1225 C CA  . THR A 1 172 ? 48.963 93.250  5.599   1.00 36.65  ? 165 THR H CA  1 
ATOM   1226 C C   . THR A 1 172 ? 48.730 93.278  7.129   1.00 35.53  ? 165 THR H C   1 
ATOM   1227 O O   . THR A 1 172 ? 49.557 92.772  7.912   1.00 32.41  ? 165 THR H O   1 
ATOM   1228 C CB  . THR A 1 172 ? 48.977 91.846  4.933   1.00 36.85  ? 165 THR H CB  1 
ATOM   1229 O OG1 . THR A 1 172 ? 49.398 91.997  3.568   1.00 39.15  ? 165 THR H OG1 1 
ATOM   1230 C CG2 . THR A 1 172 ? 47.575 91.177  4.958   1.00 35.41  ? 165 THR H CG2 1 
ATOM   1231 N N   . PHE A 1 173 ? 47.653 93.948  7.551   1.00 33.59  ? 166 PHE H N   1 
ATOM   1232 C CA  . PHE A 1 173 ? 47.414 94.164  8.982   1.00 33.08  ? 166 PHE H CA  1 
ATOM   1233 C C   . PHE A 1 173 ? 46.800 92.914  9.616   1.00 33.68  ? 166 PHE H C   1 
ATOM   1234 O O   . PHE A 1 173 ? 46.123 92.149  8.928   1.00 35.92  ? 166 PHE H O   1 
ATOM   1235 C CB  . PHE A 1 173 ? 46.543 95.405  9.220   1.00 31.82  ? 166 PHE H CB  1 
ATOM   1236 C CG  . PHE A 1 173 ? 47.274 96.695  8.953   1.00 32.73  ? 166 PHE H CG  1 
ATOM   1237 C CD1 . PHE A 1 173 ? 48.026 97.289  9.948   1.00 35.26  ? 166 PHE H CD1 1 
ATOM   1238 C CD2 . PHE A 1 173 ? 47.236 97.303  7.699   1.00 33.28  ? 166 PHE H CD2 1 
ATOM   1239 C CE1 . PHE A 1 173 ? 48.718 98.461  9.711   1.00 34.73  ? 166 PHE H CE1 1 
ATOM   1240 C CE2 . PHE A 1 173 ? 47.928 98.475  7.447   1.00 33.35  ? 166 PHE H CE2 1 
ATOM   1241 C CZ  . PHE A 1 173 ? 48.677 99.057  8.458   1.00 35.82  ? 166 PHE H CZ  1 
ATOM   1242 N N   . PRO A 1 174 ? 47.077 92.668  10.920  1.00 33.81  ? 167 PRO H N   1 
ATOM   1243 C CA  . PRO A 1 174 ? 46.261 91.674  11.615  1.00 32.32  ? 167 PRO H CA  1 
ATOM   1244 C C   . PRO A 1 174 ? 44.767 91.925  11.439  1.00 32.29  ? 167 PRO H C   1 
ATOM   1245 O O   . PRO A 1 174 ? 44.310 93.082  11.494  1.00 30.39  ? 167 PRO H O   1 
ATOM   1246 C CB  . PRO A 1 174 ? 46.668 91.857  13.077  1.00 32.26  ? 167 PRO H CB  1 
ATOM   1247 C CG  . PRO A 1 174 ? 48.099 92.274  13.021  1.00 33.39  ? 167 PRO H CG  1 
ATOM   1248 C CD  . PRO A 1 174 ? 48.220 93.108  11.758  1.00 34.02  ? 167 PRO H CD  1 
ATOM   1249 N N   . ALA A 1 175 ? 44.040 90.850  11.157  1.00 33.33  ? 168 ALA H N   1 
ATOM   1250 C CA  . ALA A 1 175 ? 42.581 90.833  11.210  1.00 34.45  ? 168 ALA H CA  1 
ATOM   1251 C C   . ALA A 1 175 ? 42.053 91.371  12.535  1.00 34.83  ? 168 ALA H C   1 
ATOM   1252 O O   . ALA A 1 175 ? 42.621 91.123  13.624  1.00 34.20  ? 168 ALA H O   1 
ATOM   1253 C CB  . ALA A 1 175 ? 42.072 89.409  11.015  1.00 36.91  ? 168 ALA H CB  1 
ATOM   1254 N N   . VAL A 1 176 ? 40.956 92.099  12.433  1.00 35.51  ? 169 VAL H N   1 
ATOM   1255 C CA  . VAL A 1 176 ? 40.241 92.543  13.601  1.00 36.60  ? 169 VAL H CA  1 
ATOM   1256 C C   . VAL A 1 176 ? 38.884 91.888  13.557  1.00 38.04  ? 169 VAL H C   1 
ATOM   1257 O O   . VAL A 1 176 ? 38.251 91.796  12.497  1.00 35.02  ? 169 VAL H O   1 
ATOM   1258 C CB  . VAL A 1 176 ? 40.105 94.075  13.695  1.00 38.89  ? 169 VAL H CB  1 
ATOM   1259 C CG1 . VAL A 1 176 ? 41.451 94.708  13.971  1.00 38.45  ? 169 VAL H CG1 1 
ATOM   1260 C CG2 . VAL A 1 176 ? 39.517 94.677  12.433  1.00 44.04  ? 169 VAL H CG2 1 
ATOM   1261 N N   . LEU A 1 177 ? 38.439 91.416  14.713  1.00 38.68  ? 170 LEU H N   1 
ATOM   1262 C CA  . LEU A 1 177 ? 37.147 90.807  14.799  1.00 39.26  ? 170 LEU H CA  1 
ATOM   1263 C C   . LEU A 1 177 ? 36.143 91.910  15.106  1.00 41.34  ? 170 LEU H C   1 
ATOM   1264 O O   . LEU A 1 177 ? 36.333 92.733  15.988  1.00 39.45  ? 170 LEU H O   1 
ATOM   1265 C CB  . LEU A 1 177 ? 37.115 89.671  15.819  1.00 40.16  ? 170 LEU H CB  1 
ATOM   1266 C CG  . LEU A 1 177 ? 35.771 88.932  15.774  1.00 40.33  ? 170 LEU H CG  1 
ATOM   1267 C CD1 . LEU A 1 177 ? 35.638 88.039  14.553  1.00 39.07  ? 170 LEU H CD1 1 
ATOM   1268 C CD2 . LEU A 1 177 ? 35.599 88.121  17.036  1.00 41.54  ? 170 LEU H CD2 1 
ATOM   1269 N N   . GLN A 1 178 ? 35.072 91.921  14.338  1.00 43.85  ? 171 GLN H N   1 
ATOM   1270 C CA  . GLN A 1 178 ? 34.073 92.932  14.464  1.00 44.21  ? 171 GLN H CA  1 
ATOM   1271 C C   . GLN A 1 178 ? 32.938 92.378  15.317  1.00 44.89  ? 171 GLN H C   1 
ATOM   1272 O O   . GLN A 1 178 ? 32.817 91.161  15.524  1.00 45.26  ? 171 GLN H O   1 
ATOM   1273 C CB  . GLN A 1 178 ? 33.607 93.335  13.083  1.00 44.49  ? 171 GLN H CB  1 
ATOM   1274 C CG  . GLN A 1 178 ? 34.765 93.769  12.206  1.00 45.95  ? 171 GLN H CG  1 
ATOM   1275 C CD  . GLN A 1 178 ? 34.408 93.926  10.754  1.00 48.36  ? 171 GLN H CD  1 
ATOM   1276 O OE1 . GLN A 1 178 ? 34.576 94.997  10.195  1.00 58.55  ? 171 GLN H OE1 1 
ATOM   1277 N NE2 . GLN A 1 178 ? 33.947 92.858  10.121  1.00 48.64  ? 171 GLN H NE2 1 
ATOM   1278 N N   . SER A 1 179 ? 32.119 93.300  15.811  1.00 47.39  ? 172 SER H N   1 
ATOM   1279 C CA  . SER A 1 179 ? 31.022 93.025  16.761  1.00 46.16  ? 172 SER H CA  1 
ATOM   1280 C C   . SER A 1 179 ? 29.965 92.180  16.106  1.00 43.85  ? 172 SER H C   1 
ATOM   1281 O O   . SER A 1 179 ? 29.208 91.513  16.773  1.00 42.63  ? 172 SER H O   1 
ATOM   1282 C CB  . SER A 1 179 ? 30.409 94.337  17.211  1.00 45.16  ? 172 SER H CB  1 
ATOM   1283 O OG  . SER A 1 179 ? 30.337 95.180  16.079  1.00 47.44  ? 172 SER H OG  1 
ATOM   1284 N N   . SER A 1 180 ? 29.916 92.251  14.779  1.00 44.03  ? 173 SER H N   1 
ATOM   1285 C CA  . SER A 1 180 ? 29.164 91.310  13.960  1.00 42.82  ? 173 SER H CA  1 
ATOM   1286 C C   . SER A 1 180 ? 29.729 89.862  13.888  1.00 43.21  ? 173 SER H C   1 
ATOM   1287 O O   . SER A 1 180 ? 29.089 88.995  13.296  1.00 43.51  ? 173 SER H O   1 
ATOM   1288 C CB  . SER A 1 180 ? 29.072 91.873  12.532  1.00 42.06  ? 173 SER H CB  1 
ATOM   1289 O OG  . SER A 1 180 ? 30.353 91.962  11.941  1.00 42.34  ? 173 SER H OG  1 
ATOM   1290 N N   . GLY A 1 181 ? 30.925 89.613  14.437  1.00 40.15  ? 174 GLY H N   1 
ATOM   1291 C CA  . GLY A 1 181 ? 31.594 88.313  14.331  1.00 38.32  ? 174 GLY H CA  1 
ATOM   1292 C C   . GLY A 1 181 ? 32.283 88.016  13.012  1.00 36.93  ? 174 GLY H C   1 
ATOM   1293 O O   . GLY A 1 181 ? 32.762 86.886  12.781  1.00 39.05  ? 174 GLY H O   1 
ATOM   1294 N N   . LEU A 1 182 ? 32.343 89.015  12.148  1.00 34.29  ? 175 LEU H N   1 
ATOM   1295 C CA  . LEU A 1 182 ? 33.106 88.916  10.912  1.00 34.72  ? 175 LEU H CA  1 
ATOM   1296 C C   . LEU A 1 182 ? 34.430 89.641  11.058  1.00 31.91  ? 175 LEU H C   1 
ATOM   1297 O O   . LEU A 1 182 ? 34.469 90.743  11.599  1.00 32.15  ? 175 LEU H O   1 
ATOM   1298 C CB  . LEU A 1 182 ? 32.320 89.505  9.741   1.00 37.43  ? 175 LEU H CB  1 
ATOM   1299 C CG  . LEU A 1 182 ? 30.919 88.918  9.558   1.00 38.10  ? 175 LEU H CG  1 
ATOM   1300 C CD1 . LEU A 1 182 ? 30.095 89.753  8.586   1.00 40.71  ? 175 LEU H CD1 1 
ATOM   1301 C CD2 . LEU A 1 182 ? 31.039 87.475  9.095   1.00 37.65  ? 175 LEU H CD2 1 
ATOM   1302 N N   . TYR A 1 183 ? 35.501 88.997  10.596  1.00 31.19  ? 176 TYR H N   1 
ATOM   1303 C CA  . TYR A 1 183 ? 36.798 89.629  10.442  1.00 33.18  ? 176 TYR H CA  1 
ATOM   1304 C C   . TYR A 1 183 ? 36.868 90.597  9.268   1.00 34.98  ? 176 TYR H C   1 
ATOM   1305 O O   . TYR A 1 183 ? 36.153 90.479  8.259   1.00 32.78  ? 176 TYR H O   1 
ATOM   1306 C CB  . TYR A 1 183 ? 37.892 88.618  10.218  1.00 33.00  ? 176 TYR H CB  1 
ATOM   1307 C CG  . TYR A 1 183 ? 38.058 87.683  11.369  1.00 36.43  ? 176 TYR H CG  1 
ATOM   1308 C CD1 . TYR A 1 183 ? 38.783 88.066  12.503  1.00 35.50  ? 176 TYR H CD1 1 
ATOM   1309 C CD2 . TYR A 1 183 ? 37.485 86.407  11.341  1.00 36.54  ? 176 TYR H CD2 1 
ATOM   1310 C CE1 . TYR A 1 183 ? 38.947 87.203  13.572  1.00 36.76  ? 176 TYR H CE1 1 
ATOM   1311 C CE2 . TYR A 1 183 ? 37.633 85.547  12.412  1.00 38.79  ? 176 TYR H CE2 1 
ATOM   1312 C CZ  . TYR A 1 183 ? 38.369 85.947  13.519  1.00 38.14  ? 176 TYR H CZ  1 
ATOM   1313 O OH  . TYR A 1 183 ? 38.522 85.098  14.568  1.00 41.19  ? 176 TYR H OH  1 
ATOM   1314 N N   . SER A 1 184 ? 37.823 91.508  9.412   1.00 35.65  ? 177 SER H N   1 
ATOM   1315 C CA  . SER A 1 184 ? 38.091 92.546  8.445   1.00 35.37  ? 177 SER H CA  1 
ATOM   1316 C C   . SER A 1 184 ? 39.556 92.957  8.604   1.00 35.48  ? 177 SER H C   1 
ATOM   1317 O O   . SER A 1 184 ? 40.116 92.951  9.709   1.00 30.70  ? 177 SER H O   1 
ATOM   1318 C CB  . SER A 1 184 ? 37.115 93.723  8.683   1.00 37.83  ? 177 SER H CB  1 
ATOM   1319 O OG  . SER A 1 184 ? 37.357 94.828  7.841   1.00 38.94  ? 177 SER H OG  1 
ATOM   1320 N N   . LEU A 1 185 ? 40.175 93.302  7.491   1.00 35.10  ? 178 LEU H N   1 
ATOM   1321 C CA  . LEU A 1 185 ? 41.539 93.778  7.505   1.00 35.29  ? 178 LEU H CA  1 
ATOM   1322 C C   . LEU A 1 185 ? 41.818 94.657  6.309   1.00 36.26  ? 178 LEU H C   1 
ATOM   1323 O O   . LEU A 1 185 ? 41.054 94.667  5.336   1.00 36.64  ? 178 LEU H O   1 
ATOM   1324 C CB  . LEU A 1 185 ? 42.537 92.601  7.503   1.00 36.23  ? 178 LEU H CB  1 
ATOM   1325 C CG  . LEU A 1 185 ? 42.824 91.720  6.270   1.00 35.17  ? 178 LEU H CG  1 
ATOM   1326 C CD1 . LEU A 1 185 ? 43.667 92.377  5.188   1.00 36.87  ? 178 LEU H CD1 1 
ATOM   1327 C CD2 . LEU A 1 185 ? 43.575 90.489  6.737   1.00 35.01  ? 178 LEU H CD2 1 
ATOM   1328 N N   . SER A 1 186 ? 42.958 95.341  6.380   1.00 33.13  ? 179 SER H N   1 
ATOM   1329 C CA  . SER A 1 186 ? 43.517 96.048  5.243   1.00 32.98  ? 179 SER H CA  1 
ATOM   1330 C C   . SER A 1 186 ? 44.901 95.518  4.894   1.00 30.09  ? 179 SER H C   1 
ATOM   1331 O O   . SER A 1 186 ? 45.642 95.031  5.755   1.00 29.72  ? 179 SER H O   1 
ATOM   1332 C CB  . SER A 1 186 ? 43.592 97.547  5.536   1.00 35.76  ? 179 SER H CB  1 
ATOM   1333 O OG  . SER A 1 186 ? 42.352 98.173  5.238   1.00 39.92  ? 179 SER H OG  1 
ATOM   1334 N N   . SER A 1 187 ? 45.225 95.619  3.611   1.00 30.13  ? 180 SER H N   1 
ATOM   1335 C CA  . SER A 1 187 ? 46.575 95.354  3.083   1.00 30.79  ? 180 SER H CA  1 
ATOM   1336 C C   . SER A 1 187 ? 46.971 96.548  2.217   1.00 33.71  ? 180 SER H C   1 
ATOM   1337 O O   . SER A 1 187 ? 46.248 96.892  1.252   1.00 33.63  ? 180 SER H O   1 
ATOM   1338 C CB  . SER A 1 187 ? 46.602 94.056  2.258   1.00 32.07  ? 180 SER H CB  1 
ATOM   1339 O OG  . SER A 1 187 ? 47.889 93.784  1.734   1.00 29.89  ? 180 SER H OG  1 
ATOM   1340 N N   . VAL A 1 188 ? 48.092 97.191  2.573   1.00 32.81  ? 181 VAL H N   1 
ATOM   1341 C CA  . VAL A 1 188 ? 48.529 98.408  1.909   1.00 33.74  ? 181 VAL H CA  1 
ATOM   1342 C C   . VAL A 1 188 ? 49.979 98.280  1.462   1.00 33.67  ? 181 VAL H C   1 
ATOM   1343 O O   . VAL A 1 188 ? 50.747 97.449  1.968   1.00 39.67  ? 181 VAL H O   1 
ATOM   1344 C CB  . VAL A 1 188 ? 48.345 99.681  2.790   1.00 34.68  ? 181 VAL H CB  1 
ATOM   1345 C CG1 . VAL A 1 188 ? 46.921 99.792  3.319   1.00 34.25  ? 181 VAL H CG1 1 
ATOM   1346 C CG2 . VAL A 1 188 ? 49.324 99.700  3.945   1.00 34.13  ? 181 VAL H CG2 1 
ATOM   1347 N N   . VAL A 1 189 ? 50.345 99.131  0.521   1.00 31.37  ? 182 VAL H N   1 
ATOM   1348 C CA  . VAL A 1 189 ? 51.685 99.118  -0.058  1.00 32.95  ? 182 VAL H CA  1 
ATOM   1349 C C   . VAL A 1 189 ? 52.059 100.542 -0.423  1.00 31.27  ? 182 VAL H C   1 
ATOM   1350 O O   . VAL A 1 189 ? 51.172 101.375 -0.645  1.00 29.76  ? 182 VAL H O   1 
ATOM   1351 C CB  . VAL A 1 189 ? 51.757 98.131  -1.266  1.00 34.70  ? 182 VAL H CB  1 
ATOM   1352 C CG1 . VAL A 1 189 ? 50.758 98.473  -2.362  1.00 35.78  ? 182 VAL H CG1 1 
ATOM   1353 C CG2 . VAL A 1 189 ? 53.154 98.053  -1.842  1.00 37.86  ? 182 VAL H CG2 1 
ATOM   1354 N N   . THR A 1 190 ? 53.357 100.841 -0.436  1.00 31.31  ? 183 THR H N   1 
ATOM   1355 C CA  . THR A 1 190 ? 53.840 102.138 -0.930  1.00 33.54  ? 183 THR H CA  1 
ATOM   1356 C C   . THR A 1 190 ? 54.622 101.908 -2.202  1.00 33.91  ? 183 THR H C   1 
ATOM   1357 O O   . THR A 1 190 ? 55.460 101.019 -2.238  1.00 35.50  ? 183 THR H O   1 
ATOM   1358 C CB  . THR A 1 190 ? 54.749 102.839 0.061   1.00 35.21  ? 183 THR H CB  1 
ATOM   1359 O OG1 . THR A 1 190 ? 55.871 101.990 0.309   1.00 44.44  ? 183 THR H OG1 1 
ATOM   1360 C CG2 . THR A 1 190 ? 54.005 103.132 1.350   1.00 33.88  ? 183 THR H CG2 1 
ATOM   1361 N N   . VAL A 1 191 ? 54.314 102.669 -3.249  1.00 33.80  ? 184 VAL H N   1 
ATOM   1362 C CA  . VAL A 1 191 ? 54.953 102.497 -4.555  1.00 34.00  ? 184 VAL H CA  1 
ATOM   1363 C C   . VAL A 1 191 ? 55.462 103.834 -5.120  1.00 38.25  ? 184 VAL H C   1 
ATOM   1364 O O   . VAL A 1 191 ? 54.959 104.883 -4.733  1.00 36.64  ? 184 VAL H O   1 
ATOM   1365 C CB  . VAL A 1 191 ? 53.986 101.873 -5.555  1.00 32.26  ? 184 VAL H CB  1 
ATOM   1366 C CG1 . VAL A 1 191 ? 53.456 100.547 -5.014  1.00 33.89  ? 184 VAL H CG1 1 
ATOM   1367 C CG2 . VAL A 1 191 ? 52.855 102.830 -5.890  1.00 31.73  ? 184 VAL H CG2 1 
ATOM   1368 N N   . PRO A 1 192 ? 56.456 103.802 -6.048  1.00 41.59  ? 185 PRO H N   1 
ATOM   1369 C CA  . PRO A 1 192 ? 56.845 105.084 -6.636  1.00 39.96  ? 185 PRO H CA  1 
ATOM   1370 C C   . PRO A 1 192 ? 55.689 105.646 -7.382  1.00 38.06  ? 185 PRO H C   1 
ATOM   1371 O O   . PRO A 1 192 ? 54.973 104.912 -8.065  1.00 37.39  ? 185 PRO H O   1 
ATOM   1372 C CB  . PRO A 1 192 ? 57.998 104.719 -7.585  1.00 42.26  ? 185 PRO H CB  1 
ATOM   1373 C CG  . PRO A 1 192 ? 58.535 103.415 -7.059  1.00 41.49  ? 185 PRO H CG  1 
ATOM   1374 C CD  . PRO A 1 192 ? 57.325 102.702 -6.524  1.00 41.85  ? 185 PRO H CD  1 
ATOM   1375 N N   . SER A 1 193 ? 55.459 106.932 -7.196  1.00 40.16  ? 186 SER H N   1 
ATOM   1376 C CA  . SER A 1 193 ? 54.369 107.612 -7.884  1.00 42.11  ? 186 SER H CA  1 
ATOM   1377 C C   . SER A 1 193 ? 54.454 107.441 -9.393  1.00 38.85  ? 186 SER H C   1 
ATOM   1378 O O   . SER A 1 193 ? 53.437 107.252 -10.038 1.00 38.31  ? 186 SER H O   1 
ATOM   1379 C CB  . SER A 1 193 ? 54.377 109.084 -7.514  1.00 46.97  ? 186 SER H CB  1 
ATOM   1380 O OG  . SER A 1 193 ? 54.021 109.223 -6.137  1.00 55.07  ? 186 SER H OG  1 
ATOM   1381 N N   . SER A 1 194 ? 55.668 107.451 -9.938  1.00 37.75  ? 187 SER H N   1 
ATOM   1382 C CA  . SER A 1 194 ? 55.865 107.238 -11.384 1.00 41.20  ? 187 SER H CA  1 
ATOM   1383 C C   . SER A 1 194 ? 55.279 105.906 -11.876 1.00 42.23  ? 187 SER H C   1 
ATOM   1384 O O   . SER A 1 194 ? 54.605 105.869 -12.902 1.00 47.54  ? 187 SER H O   1 
ATOM   1385 C CB  . SER A 1 194 ? 57.354 107.406 -11.807 1.00 40.02  ? 187 SER H CB  1 
ATOM   1386 O OG  . SER A 1 194 ? 58.276 106.726 -10.976 1.00 37.04  ? 187 SER H OG  1 
ATOM   1387 N N   . SER A 1 195 ? 55.483 104.835 -11.112 1.00 41.73  ? 188 SER H N   1 
ATOM   1388 C CA  . SER A 1 195 ? 54.934 103.506 -11.442 1.00 40.43  ? 188 SER H CA  1 
ATOM   1389 C C   . SER A 1 195 ? 53.427 103.457 -11.786 1.00 38.72  ? 188 SER H C   1 
ATOM   1390 O O   . SER A 1 195 ? 53.006 102.568 -12.513 1.00 36.20  ? 188 SER H O   1 
ATOM   1391 C CB  . SER A 1 195 ? 55.202 102.520 -10.303 1.00 40.84  ? 188 SER H CB  1 
ATOM   1392 O OG  . SER A 1 195 ? 54.080 102.416 -9.438  1.00 40.79  ? 188 SER H OG  1 
ATOM   1393 N N   . LEU A 1 196 ? 52.634 104.403 -11.273 1.00 39.53  ? 189 LEU H N   1 
ATOM   1394 C CA  . LEU A 1 196 ? 51.160 104.417 -11.482 1.00 37.43  ? 189 LEU H CA  1 
ATOM   1395 C C   . LEU A 1 196 ? 50.719 104.695 -12.901 1.00 39.71  ? 189 LEU H C   1 
ATOM   1396 O O   . LEU A 1 196 ? 49.616 104.346 -13.263 1.00 41.50  ? 189 LEU H O   1 
ATOM   1397 C CB  . LEU A 1 196 ? 50.487 105.420 -10.556 1.00 35.86  ? 189 LEU H CB  1 
ATOM   1398 C CG  . LEU A 1 196 ? 50.694 105.039 -9.085  1.00 35.16  ? 189 LEU H CG  1 
ATOM   1399 C CD1 . LEU A 1 196 ? 50.285 106.192 -8.189  1.00 33.81  ? 189 LEU H CD1 1 
ATOM   1400 C CD2 . LEU A 1 196 ? 49.974 103.744 -8.716  1.00 34.96  ? 189 LEU H CD2 1 
ATOM   1401 N N   . GLY A 1 197 ? 51.587 105.329 -13.685 1.00 40.64  ? 190 GLY H N   1 
ATOM   1402 C CA  . GLY A 1 197 ? 51.427 105.430 -15.130 1.00 39.37  ? 190 GLY H CA  1 
ATOM   1403 C C   . GLY A 1 197 ? 51.790 104.185 -15.932 1.00 39.09  ? 190 GLY H C   1 
ATOM   1404 O O   . GLY A 1 197 ? 51.258 104.003 -17.008 1.00 39.69  ? 190 GLY H O   1 
ATOM   1405 N N   . THR A 1 198 ? 52.680 103.327 -15.429 1.00 39.48  ? 191 THR H N   1 
ATOM   1406 C CA  . THR A 1 198 ? 53.174 102.166 -16.218 1.00 38.68  ? 191 THR H CA  1 
ATOM   1407 C C   . THR A 1 198 ? 52.792 100.783 -15.655 1.00 39.07  ? 191 THR H C   1 
ATOM   1408 O O   . THR A 1 198 ? 53.244 99.738  -16.154 1.00 36.10  ? 191 THR H O   1 
ATOM   1409 C CB  . THR A 1 198 ? 54.696 102.260 -16.413 1.00 37.67  ? 191 THR H CB  1 
ATOM   1410 O OG1 . THR A 1 198 ? 55.360 101.954 -15.195 1.00 41.35  ? 191 THR H OG1 1 
ATOM   1411 C CG2 . THR A 1 198 ? 55.100 103.672 -16.836 1.00 40.26  ? 191 THR H CG2 1 
ATOM   1412 N N   . GLN A 1 199 ? 51.941 100.789 -14.634 1.00 40.32  ? 192 GLN H N   1 
ATOM   1413 C CA  . GLN A 1 199 ? 51.455 99.575  -13.997 1.00 40.80  ? 192 GLN H CA  1 
ATOM   1414 C C   . GLN A 1 199 ? 50.094 99.850  -13.331 1.00 40.39  ? 192 GLN H C   1 
ATOM   1415 O O   . GLN A 1 199 ? 49.793 100.959 -12.866 1.00 37.71  ? 192 GLN H O   1 
ATOM   1416 C CB  . GLN A 1 199 ? 52.498 99.050  -12.993 1.00 40.38  ? 192 GLN H CB  1 
ATOM   1417 C CG  . GLN A 1 199 ? 52.103 97.801  -12.208 1.00 43.76  ? 192 GLN H CG  1 
ATOM   1418 C CD  . GLN A 1 199 ? 51.921 96.548  -13.085 1.00 45.53  ? 192 GLN H CD  1 
ATOM   1419 O OE1 . GLN A 1 199 ? 50.947 96.456  -13.832 1.00 46.44  ? 192 GLN H OE1 1 
ATOM   1420 N NE2 . GLN A 1 199 ? 52.842 95.557  -12.963 1.00 42.40  ? 192 GLN H NE2 1 
ATOM   1421 N N   . THR A 1 200 ? 49.274 98.815  -13.342 1.00 40.24  ? 193 THR H N   1 
ATOM   1422 C CA  . THR A 1 200 ? 48.021 98.779  -12.642 1.00 39.55  ? 193 THR H CA  1 
ATOM   1423 C C   . THR A 1 200 ? 48.122 97.727  -11.515 1.00 38.52  ? 193 THR H C   1 
ATOM   1424 O O   . THR A 1 200 ? 48.243 96.516  -11.741 1.00 34.39  ? 193 THR H O   1 
ATOM   1425 C CB  . THR A 1 200 ? 46.903 98.456  -13.619 1.00 42.98  ? 193 THR H CB  1 
ATOM   1426 O OG1 . THR A 1 200 ? 47.297 97.310  -14.378 1.00 51.13  ? 193 THR H OG1 1 
ATOM   1427 C CG2 . THR A 1 200 ? 46.660 99.664  -14.569 1.00 42.73  ? 193 THR H CG2 1 
ATOM   1428 N N   . TYR A 1 201 ? 48.105 98.233  -10.291 1.00 35.71  ? 194 TYR H N   1 
ATOM   1429 C CA  . TYR A 1 201 ? 48.260 97.429  -9.114  1.00 33.38  ? 194 TYR H CA  1 
ATOM   1430 C C   . TYR A 1 201 ? 47.004 96.697  -8.723  1.00 32.38  ? 194 TYR H C   1 
ATOM   1431 O O   . TYR A 1 201 ? 45.920 97.279  -8.725  1.00 30.80  ? 194 TYR H O   1 
ATOM   1432 C CB  . TYR A 1 201 ? 48.721 98.294  -7.965  1.00 32.77  ? 194 TYR H CB  1 
ATOM   1433 C CG  . TYR A 1 201 ? 50.132 98.752  -8.182  1.00 34.33  ? 194 TYR H CG  1 
ATOM   1434 C CD1 . TYR A 1 201 ? 51.209 97.904  -7.939  1.00 33.30  ? 194 TYR H CD1 1 
ATOM   1435 C CD2 . TYR A 1 201 ? 50.394 100.023 -8.656  1.00 34.14  ? 194 TYR H CD2 1 
ATOM   1436 C CE1 . TYR A 1 201 ? 52.507 98.346  -8.128  1.00 32.81  ? 194 TYR H CE1 1 
ATOM   1437 C CE2 . TYR A 1 201 ? 51.682 100.458 -8.856  1.00 32.87  ? 194 TYR H CE2 1 
ATOM   1438 C CZ  . TYR A 1 201 ? 52.729 99.625  -8.596  1.00 33.32  ? 194 TYR H CZ  1 
ATOM   1439 O OH  . TYR A 1 201 ? 53.992 100.118 -8.815  1.00 36.28  ? 194 TYR H OH  1 
ATOM   1440 N N   . ILE A 1 202 ? 47.217 95.436  -8.329  1.00 31.72  ? 195 ILE H N   1 
ATOM   1441 C CA  . ILE A 1 202 ? 46.200 94.420  -8.132  1.00 31.11  ? 195 ILE H CA  1 
ATOM   1442 C C   . ILE A 1 202 ? 46.532 93.683  -6.865  1.00 30.27  ? 195 ILE H C   1 
ATOM   1443 O O   . ILE A 1 202 ? 47.646 93.196  -6.700  1.00 31.50  ? 195 ILE H O   1 
ATOM   1444 C CB  . ILE A 1 202 ? 46.185 93.380  -9.252  1.00 32.43  ? 195 ILE H CB  1 
ATOM   1445 C CG1 . ILE A 1 202 ? 45.852 94.080  -10.580 1.00 35.22  ? 195 ILE H CG1 1 
ATOM   1446 C CG2 . ILE A 1 202 ? 45.191 92.243  -8.919  1.00 32.00  ? 195 ILE H CG2 1 
ATOM   1447 C CD1 . ILE A 1 202 ? 45.824 93.164  -11.814 1.00 37.52  ? 195 ILE H CD1 1 
ATOM   1448 N N   . CYS A 1 203 ? 45.546 93.597  -5.982  1.00 31.48  ? 196 CYS H N   1 
ATOM   1449 C CA  . CYS A 1 203 ? 45.653 92.837  -4.769  1.00 32.15  ? 196 CYS H CA  1 
ATOM   1450 C C   . CYS A 1 203 ? 44.901 91.562  -5.045  1.00 31.86  ? 196 CYS H C   1 
ATOM   1451 O O   . CYS A 1 203 ? 43.724 91.563  -5.394  1.00 35.01  ? 196 CYS H O   1 
ATOM   1452 C CB  . CYS A 1 203 ? 45.057 93.561  -3.567  1.00 32.12  ? 196 CYS H CB  1 
ATOM   1453 S SG  . CYS A 1 203 ? 43.278 93.838  -3.670  1.00 35.90  ? 196 CYS H SG  1 
ATOM   1454 N N   . ASN A 1 204 ? 45.600 90.469  -4.872  1.00 32.91  ? 197 ASN H N   1 
ATOM   1455 C CA  . ASN A 1 204 ? 45.050 89.163  -5.096  1.00 34.71  ? 197 ASN H CA  1 
ATOM   1456 C C   . ASN A 1 204 ? 44.678 88.606  -3.731  1.00 34.41  ? 197 ASN H C   1 
ATOM   1457 O O   . ASN A 1 204 ? 45.566 88.365  -2.914  1.00 32.98  ? 197 ASN H O   1 
ATOM   1458 C CB  . ASN A 1 204 ? 46.112 88.313  -5.788  1.00 35.40  ? 197 ASN H CB  1 
ATOM   1459 C CG  . ASN A 1 204 ? 45.817 86.848  -5.702  1.00 38.04  ? 197 ASN H CG  1 
ATOM   1460 O OD1 . ASN A 1 204 ? 46.602 86.080  -5.120  1.00 41.12  ? 197 ASN H OD1 1 
ATOM   1461 N ND2 . ASN A 1 204 ? 44.664 86.446  -6.227  1.00 36.79  ? 197 ASN H ND2 1 
ATOM   1462 N N   . VAL A 1 205 ? 43.381 88.423  -3.488  1.00 34.04  ? 198 VAL H N   1 
ATOM   1463 C CA  . VAL A 1 205 ? 42.894 87.958  -2.193  1.00 36.54  ? 198 VAL H CA  1 
ATOM   1464 C C   . VAL A 1 205 ? 42.369 86.529  -2.272  1.00 37.24  ? 198 VAL H C   1 
ATOM   1465 O O   . VAL A 1 205 ? 41.462 86.263  -3.026  1.00 38.24  ? 198 VAL H O   1 
ATOM   1466 C CB  . VAL A 1 205 ? 41.792 88.890  -1.667  1.00 36.74  ? 198 VAL H CB  1 
ATOM   1467 C CG1 . VAL A 1 205 ? 41.317 88.457  -0.274  1.00 36.60  ? 198 VAL H CG1 1 
ATOM   1468 C CG2 . VAL A 1 205 ? 42.303 90.330  -1.636  1.00 34.70  ? 198 VAL H CG2 1 
ATOM   1469 N N   . ASN A 1 206 ? 42.957 85.623  -1.505  1.00 39.47  ? 199 ASN H N   1 
ATOM   1470 C CA  . ASN A 1 206 ? 42.453 84.263  -1.386  1.00 45.81  ? 199 ASN H CA  1 
ATOM   1471 C C   . ASN A 1 206 ? 41.887 83.980  0.023   1.00 46.79  ? 199 ASN H C   1 
ATOM   1472 O O   . ASN A 1 206 ? 42.581 84.138  1.046   1.00 48.25  ? 199 ASN H O   1 
ATOM   1473 C CB  . ASN A 1 206 ? 43.534 83.244  -1.787  1.00 51.26  ? 199 ASN H CB  1 
ATOM   1474 C CG  . ASN A 1 206 ? 43.058 81.780  -1.698  1.00 60.25  ? 199 ASN H CG  1 
ATOM   1475 O OD1 . ASN A 1 206 ? 43.769 80.935  -1.139  1.00 64.26  ? 199 ASN H OD1 1 
ATOM   1476 N ND2 . ASN A 1 206 ? 41.872 81.470  -2.248  1.00 60.98  ? 199 ASN H ND2 1 
ATOM   1477 N N   . HIS A 1 207 ? 40.617 83.573  0.053   1.00 42.75  ? 200 HIS H N   1 
ATOM   1478 C CA  . HIS A 1 207 ? 39.997 83.007  1.247   1.00 40.00  ? 200 HIS H CA  1 
ATOM   1479 C C   . HIS A 1 207 ? 39.693 81.516  1.032   1.00 40.11  ? 200 HIS H C   1 
ATOM   1480 O O   . HIS A 1 207 ? 38.657 81.159  0.472   1.00 37.83  ? 200 HIS H O   1 
ATOM   1481 C CB  . HIS A 1 207 ? 38.738 83.785  1.574   1.00 37.44  ? 200 HIS H CB  1 
ATOM   1482 C CG  . HIS A 1 207 ? 38.226 83.524  2.938   1.00 37.63  ? 200 HIS H CG  1 
ATOM   1483 N ND1 . HIS A 1 207 ? 36.927 83.146  3.179   1.00 37.04  ? 200 HIS H ND1 1 
ATOM   1484 C CD2 . HIS A 1 207 ? 38.843 83.568  4.141   1.00 36.67  ? 200 HIS H CD2 1 
ATOM   1485 C CE1 . HIS A 1 207 ? 36.766 82.973  4.479   1.00 37.94  ? 200 HIS H CE1 1 
ATOM   1486 N NE2 . HIS A 1 207 ? 37.911 83.225  5.085   1.00 36.35  ? 200 HIS H NE2 1 
ATOM   1487 N N   . LYS A 1 208 ? 40.610 80.650  1.464   1.00 45.90  ? 201 LYS H N   1 
ATOM   1488 C CA  . LYS A 1 208 ? 40.454 79.190  1.285   1.00 51.16  ? 201 LYS H CA  1 
ATOM   1489 C C   . LYS A 1 208 ? 39.103 78.683  1.795   1.00 52.92  ? 201 LYS H C   1 
ATOM   1490 O O   . LYS A 1 208 ? 38.393 78.024  1.041   1.00 53.76  ? 201 LYS H O   1 
ATOM   1491 C CB  . LYS A 1 208 ? 41.582 78.389  1.945   1.00 56.76  ? 201 LYS H CB  1 
ATOM   1492 C CG  . LYS A 1 208 ? 42.929 78.525  1.263   1.00 64.93  ? 201 LYS H CG  1 
ATOM   1493 C CD  . LYS A 1 208 ? 44.011 77.752  2.001   1.00 70.53  ? 201 LYS H CD  1 
ATOM   1494 C CE  . LYS A 1 208 ? 45.368 78.036  1.374   1.00 77.48  ? 201 LYS H CE  1 
ATOM   1495 N NZ  . LYS A 1 208 ? 46.488 77.267  1.993   1.00 79.81  ? 201 LYS H NZ  1 
ATOM   1496 N N   . PRO A 1 209 ? 38.718 79.032  3.051   1.00 53.66  ? 202 PRO H N   1 
ATOM   1497 C CA  . PRO A 1 209 ? 37.489 78.466  3.629   1.00 53.28  ? 202 PRO H CA  1 
ATOM   1498 C C   . PRO A 1 209 ? 36.256 78.560  2.742   1.00 51.13  ? 202 PRO H C   1 
ATOM   1499 O O   . PRO A 1 209 ? 35.424 77.659  2.777   1.00 49.52  ? 202 PRO H O   1 
ATOM   1500 C CB  . PRO A 1 209 ? 37.279 79.295  4.897   1.00 53.70  ? 202 PRO H CB  1 
ATOM   1501 C CG  . PRO A 1 209 ? 38.640 79.716  5.285   1.00 55.85  ? 202 PRO H CG  1 
ATOM   1502 C CD  . PRO A 1 209 ? 39.383 79.944  4.003   1.00 53.48  ? 202 PRO H CD  1 
ATOM   1503 N N   . SER A 1 210 ? 36.158 79.631  1.957   1.00 48.57  ? 203 SER H N   1 
ATOM   1504 C CA  . SER A 1 210 ? 34.971 79.892  1.155   1.00 46.54  ? 203 SER H CA  1 
ATOM   1505 C C   . SER A 1 210 ? 35.245 79.804  -0.335  1.00 47.43  ? 203 SER H C   1 
ATOM   1506 O O   . SER A 1 210 ? 34.481 80.361  -1.119  1.00 44.76  ? 203 SER H O   1 
ATOM   1507 C CB  . SER A 1 210 ? 34.376 81.264  1.519   1.00 46.24  ? 203 SER H CB  1 
ATOM   1508 O OG  . SER A 1 210 ? 34.934 82.349  0.795   1.00 46.14  ? 203 SER H OG  1 
ATOM   1509 N N   . ASN A 1 211 ? 36.324 79.124  -0.729  1.00 50.12  ? 204 ASN H N   1 
ATOM   1510 C CA  . ASN A 1 211 ? 36.705 79.010  -2.156  1.00 55.46  ? 204 ASN H CA  1 
ATOM   1511 C C   . ASN A 1 211 ? 36.862 80.346  -2.902  1.00 55.37  ? 204 ASN H C   1 
ATOM   1512 O O   . ASN A 1 211 ? 36.766 80.370  -4.121  1.00 59.97  ? 204 ASN H O   1 
ATOM   1513 C CB  . ASN A 1 211 ? 35.659 78.148  -2.920  1.00 56.92  ? 204 ASN H CB  1 
ATOM   1514 C CG  . ASN A 1 211 ? 36.057 76.692  -3.056  1.00 58.35  ? 204 ASN H CG  1 
ATOM   1515 O OD1 . ASN A 1 211 ? 37.194 76.376  -3.423  1.00 59.23  ? 204 ASN H OD1 1 
ATOM   1516 N ND2 . ASN A 1 211 ? 35.101 75.788  -2.811  1.00 60.35  ? 204 ASN H ND2 1 
ATOM   1517 N N   . THR A 1 212 ? 37.101 81.445  -2.188  1.00 57.48  ? 205 THR H N   1 
ATOM   1518 C CA  . THR A 1 212 ? 37.154 82.780  -2.797  1.00 54.29  ? 205 THR H CA  1 
ATOM   1519 C C   . THR A 1 212 ? 38.571 83.069  -3.287  1.00 49.63  ? 205 THR H C   1 
ATOM   1520 O O   . THR A 1 212 ? 39.541 82.847  -2.559  1.00 42.01  ? 205 THR H O   1 
ATOM   1521 C CB  . THR A 1 212 ? 36.742 83.877  -1.791  1.00 57.40  ? 205 THR H CB  1 
ATOM   1522 O OG1 . THR A 1 212 ? 35.388 83.666  -1.389  1.00 60.80  ? 205 THR H OG1 1 
ATOM   1523 C CG2 . THR A 1 212 ? 36.845 85.289  -2.382  1.00 58.15  ? 205 THR H CG2 1 
ATOM   1524 N N   . LYS A 1 213 ? 38.646 83.539  -4.532  1.00 46.96  ? 206 LYS H N   1 
ATOM   1525 C CA  . LYS A 1 213 ? 39.810 84.205  -5.100  1.00 49.79  ? 206 LYS H CA  1 
ATOM   1526 C C   . LYS A 1 213 ? 39.258 85.480  -5.726  1.00 47.96  ? 206 LYS H C   1 
ATOM   1527 O O   . LYS A 1 213 ? 38.369 85.420  -6.567  1.00 49.06  ? 206 LYS H O   1 
ATOM   1528 C CB  . LYS A 1 213 ? 40.506 83.374  -6.180  1.00 54.02  ? 206 LYS H CB  1 
ATOM   1529 C CG  . LYS A 1 213 ? 41.321 82.169  -5.703  1.00 58.59  ? 206 LYS H CG  1 
ATOM   1530 C CD  . LYS A 1 213 ? 41.773 81.347  -6.919  1.00 64.17  ? 206 LYS H CD  1 
ATOM   1531 C CE  . LYS A 1 213 ? 42.615 80.117  -6.583  1.00 67.39  ? 206 LYS H CE  1 
ATOM   1532 N NZ  . LYS A 1 213 ? 41.934 78.799  -6.699  1.00 67.12  ? 206 LYS H NZ  1 
ATOM   1533 N N   . VAL A 1 214 ? 39.763 86.627  -5.287  1.00 46.53  ? 207 VAL H N   1 
ATOM   1534 C CA  . VAL A 1 214 ? 39.381 87.940  -5.839  1.00 47.80  ? 207 VAL H CA  1 
ATOM   1535 C C   . VAL A 1 214 ? 40.655 88.677  -6.243  1.00 46.16  ? 207 VAL H C   1 
ATOM   1536 O O   . VAL A 1 214 ? 41.687 88.558  -5.584  1.00 46.14  ? 207 VAL H O   1 
ATOM   1537 C CB  . VAL A 1 214 ? 38.563 88.778  -4.824  1.00 48.54  ? 207 VAL H CB  1 
ATOM   1538 C CG1 . VAL A 1 214 ? 38.297 90.187  -5.339  1.00 47.78  ? 207 VAL H CG1 1 
ATOM   1539 C CG2 . VAL A 1 214 ? 37.231 88.098  -4.521  1.00 47.28  ? 207 VAL H CG2 1 
ATOM   1540 N N   . ASP A 1 215 ? 40.585 89.390  -7.358  1.00 47.54  ? 208 ASP H N   1 
ATOM   1541 C CA  . ASP A 1 215 ? 41.675 90.234  -7.824  1.00 47.80  ? 208 ASP H CA  1 
ATOM   1542 C C   . ASP A 1 215 ? 41.055 91.582  -8.006  1.00 48.27  ? 208 ASP H C   1 
ATOM   1543 O O   . ASP A 1 215 ? 40.146 91.737  -8.817  1.00 51.66  ? 208 ASP H O   1 
ATOM   1544 C CB  . ASP A 1 215 ? 42.242 89.744  -9.154  1.00 49.40  ? 208 ASP H CB  1 
ATOM   1545 C CG  . ASP A 1 215 ? 43.549 88.970  -8.995  1.00 54.44  ? 208 ASP H CG  1 
ATOM   1546 O OD1 . ASP A 1 215 ? 43.851 88.447  -7.906  1.00 58.85  ? 208 ASP H OD1 1 
ATOM   1547 O OD2 . ASP A 1 215 ? 44.293 88.877  -9.984  1.00 61.19  ? 208 ASP H OD2 1 
ATOM   1548 N N   . LYS A 1 216 ? 41.512 92.553  -7.237  1.00 45.86  ? 209 LYS H N   1 
ATOM   1549 C CA  . LYS A 1 216 ? 40.985 93.900  -7.363  1.00 45.43  ? 209 LYS H CA  1 
ATOM   1550 C C   . LYS A 1 216 ? 42.090 94.826  -7.826  1.00 41.10  ? 209 LYS H C   1 
ATOM   1551 O O   . LYS A 1 216 ? 43.136 94.915  -7.205  1.00 36.44  ? 209 LYS H O   1 
ATOM   1552 C CB  . LYS A 1 216 ? 40.380 94.384  -6.040  1.00 48.27  ? 209 LYS H CB  1 
ATOM   1553 C CG  . LYS A 1 216 ? 38.994 94.983  -6.209  1.00 49.97  ? 209 LYS H CG  1 
ATOM   1554 C CD  . LYS A 1 216 ? 37.991 93.872  -6.519  1.00 52.51  ? 209 LYS H CD  1 
ATOM   1555 C CE  . LYS A 1 216 ? 36.558 94.339  -6.575  1.00 52.89  ? 209 LYS H CE  1 
ATOM   1556 N NZ  . LYS A 1 216 ? 36.476 95.602  -7.343  1.00 55.84  ? 209 LYS H NZ  1 
ATOM   1557 N N   . LYS A 1 217 ? 41.839 95.475  -8.953  1.00 41.19  ? 210 LYS H N   1 
ATOM   1558 C CA  . LYS A 1 217 ? 42.668 96.543  -9.455  1.00 40.27  ? 210 LYS H CA  1 
ATOM   1559 C C   . LYS A 1 217 ? 42.437 97.752  -8.602  1.00 35.53  ? 210 LYS H C   1 
ATOM   1560 O O   . LYS A 1 217 ? 41.294 98.136  -8.384  1.00 32.42  ? 210 LYS H O   1 
ATOM   1561 C CB  . LYS A 1 217 ? 42.281 96.888  -10.887 1.00 42.44  ? 210 LYS H CB  1 
ATOM   1562 C CG  . LYS A 1 217 ? 42.586 95.765  -11.858 1.00 47.35  ? 210 LYS H CG  1 
ATOM   1563 C CD  . LYS A 1 217 ? 42.197 96.111  -13.284 1.00 51.87  ? 210 LYS H CD  1 
ATOM   1564 C CE  . LYS A 1 217 ? 42.790 95.090  -14.245 1.00 53.24  ? 210 LYS H CE  1 
ATOM   1565 N NZ  . LYS A 1 217 ? 42.336 95.299  -15.648 1.00 54.27  ? 210 LYS H NZ  1 
ATOM   1566 N N   . VAL A 1 218 ? 43.529 98.368  -8.170  1.00 33.68  ? 211 VAL H N   1 
ATOM   1567 C CA  . VAL A 1 218 ? 43.483 99.559  -7.339  1.00 34.22  ? 211 VAL H CA  1 
ATOM   1568 C C   . VAL A 1 218 ? 43.999 100.717 -8.173  1.00 35.54  ? 211 VAL H C   1 
ATOM   1569 O O   . VAL A 1 218 ? 45.198 101.022 -8.180  1.00 33.56  ? 211 VAL H O   1 
ATOM   1570 C CB  . VAL A 1 218 ? 44.283 99.393  -6.032  1.00 31.70  ? 211 VAL H CB  1 
ATOM   1571 C CG1 . VAL A 1 218 ? 44.121 100.629 -5.160  1.00 31.44  ? 211 VAL H CG1 1 
ATOM   1572 C CG2 . VAL A 1 218 ? 43.836 98.140  -5.275  1.00 31.57  ? 211 VAL H CG2 1 
ATOM   1573 N N   . GLU A 1 219 ? 43.072 101.356 -8.871  1.00 38.34  ? 212 GLU H N   1 
ATOM   1574 C CA  . GLU A 1 219 ? 43.415 102.441 -9.769  1.00 44.03  ? 212 GLU H CA  1 
ATOM   1575 C C   . GLU A 1 219 ? 43.215 103.805 -9.115  1.00 43.03  ? 212 GLU H C   1 
ATOM   1576 O O   . GLU A 1 219 ? 42.393 103.942 -8.205  1.00 43.20  ? 212 GLU H O   1 
ATOM   1577 C CB  . GLU A 1 219 ? 42.618 102.308 -11.075 1.00 47.50  ? 212 GLU H CB  1 
ATOM   1578 C CG  . GLU A 1 219 ? 43.150 101.152 -11.924 1.00 50.50  ? 212 GLU H CG  1 
ATOM   1579 C CD  . GLU A 1 219 ? 42.484 100.988 -13.278 1.00 51.59  ? 212 GLU H CD  1 
ATOM   1580 O OE1 . GLU A 1 219 ? 43.104 100.330 -14.136 1.00 55.75  ? 212 GLU H OE1 1 
ATOM   1581 O OE2 . GLU A 1 219 ? 41.363 101.495 -13.494 1.00 54.24  ? 212 GLU H OE2 1 
ATOM   1582 N N   . PRO A 1 220 ? 43.997 104.814 -9.552  1.00 44.12  ? 213 PRO H N   1 
ATOM   1583 C CA  . PRO A 1 220 ? 43.666 106.176 -9.178  1.00 45.81  ? 213 PRO H CA  1 
ATOM   1584 C C   . PRO A 1 220 ? 42.435 106.644 -9.960  1.00 45.67  ? 213 PRO H C   1 
ATOM   1585 O O   . PRO A 1 220 ? 41.398 106.906 -9.354  1.00 49.42  ? 213 PRO H O   1 
ATOM   1586 C CB  . PRO A 1 220 ? 44.913 106.949 -9.590  1.00 43.66  ? 213 PRO H CB  1 
ATOM   1587 C CG  . PRO A 1 220 ? 45.416 106.206 -10.770 1.00 43.64  ? 213 PRO H CG  1 
ATOM   1588 C CD  . PRO A 1 220 ? 45.206 104.770 -10.396 1.00 42.97  ? 213 PRO H CD  1 
ATOM   1589 N N   . SER B 2 2   ? 42.014 81.694  44.794  1.00 67.19  ? 0   SER L N   1 
ATOM   1590 C CA  . SER B 2 2   ? 43.333 81.878  45.509  1.00 66.95  ? 0   SER L CA  1 
ATOM   1591 C C   . SER B 2 2   ? 44.481 81.093  44.855  1.00 59.67  ? 0   SER L C   1 
ATOM   1592 O O   . SER B 2 2   ? 45.387 80.593  45.546  1.00 50.11  ? 0   SER L O   1 
ATOM   1593 C CB  . SER B 2 2   ? 43.204 81.488  47.002  1.00 70.97  ? 0   SER L CB  1 
ATOM   1594 O OG  . SER B 2 2   ? 44.308 81.949  47.762  1.00 70.19  ? 0   SER L OG  1 
ATOM   1595 N N   . ASP B 2 3   ? 44.435 81.005  43.523  1.00 57.75  ? 1   ASP L N   1 
ATOM   1596 C CA  . ASP B 2 3   ? 45.490 80.385  42.739  1.00 55.24  ? 1   ASP L CA  1 
ATOM   1597 C C   . ASP B 2 3   ? 46.644 81.350  42.756  1.00 48.52  ? 1   ASP L C   1 
ATOM   1598 O O   . ASP B 2 3   ? 46.458 82.521  43.053  1.00 47.22  ? 1   ASP L O   1 
ATOM   1599 C CB  . ASP B 2 3   ? 45.048 80.170  41.292  1.00 59.76  ? 1   ASP L CB  1 
ATOM   1600 C CG  . ASP B 2 3   ? 44.258 78.896  41.106  1.00 64.45  ? 1   ASP L CG  1 
ATOM   1601 O OD1 . ASP B 2 3   ? 43.029 78.878  41.274  1.00 67.48  ? 1   ASP L OD1 1 
ATOM   1602 O OD2 . ASP B 2 3   ? 44.877 77.904  40.770  1.00 67.54  ? 1   ASP L OD2 1 
ATOM   1603 N N   . ILE B 2 4   ? 47.835 80.872  42.431  1.00 42.17  ? 2   ILE L N   1 
ATOM   1604 C CA  . ILE B 2 4   ? 48.996 81.738  42.406  1.00 40.37  ? 2   ILE L CA  1 
ATOM   1605 C C   . ILE B 2 4   ? 48.919 82.537  41.101  1.00 39.98  ? 2   ILE L C   1 
ATOM   1606 O O   . ILE B 2 4   ? 48.946 81.934  40.033  1.00 39.67  ? 2   ILE L O   1 
ATOM   1607 C CB  . ILE B 2 4   ? 50.312 80.941  42.530  1.00 39.20  ? 2   ILE L CB  1 
ATOM   1608 C CG1 . ILE B 2 4   ? 50.602 80.546  43.993  1.00 42.14  ? 2   ILE L CG1 1 
ATOM   1609 C CG2 . ILE B 2 4   ? 51.480 81.791  42.107  1.00 39.48  ? 2   ILE L CG2 1 
ATOM   1610 C CD1 . ILE B 2 4   ? 49.744 79.446  44.565  1.00 41.94  ? 2   ILE L CD1 1 
ATOM   1611 N N   . GLU B 2 5   ? 48.775 83.866  41.207  1.00 38.65  ? 3   GLU L N   1 
ATOM   1612 C CA  . GLU B 2 5   ? 48.886 84.788  40.064  1.00 39.73  ? 3   GLU L CA  1 
ATOM   1613 C C   . GLU B 2 5   ? 50.324 85.251  39.898  1.00 38.52  ? 3   GLU L C   1 
ATOM   1614 O O   . GLU B 2 5   ? 50.995 85.612  40.880  1.00 36.08  ? 3   GLU L O   1 
ATOM   1615 C CB  . GLU B 2 5   ? 48.083 86.055  40.266  1.00 44.15  ? 3   GLU L CB  1 
ATOM   1616 C CG  . GLU B 2 5   ? 46.607 85.885  40.546  1.00 53.75  ? 3   GLU L CG  1 
ATOM   1617 C CD  . GLU B 2 5   ? 45.900 87.239  40.735  1.00 67.05  ? 3   GLU L CD  1 
ATOM   1618 O OE1 . GLU B 2 5   ? 46.583 88.303  40.867  1.00 69.70  ? 3   GLU L OE1 1 
ATOM   1619 O OE2 . GLU B 2 5   ? 44.642 87.245  40.750  1.00 74.74  ? 3   GLU L OE2 1 
ATOM   1620 N N   . LEU B 2 6   ? 50.777 85.289  38.657  1.00 33.46  ? 4   LEU L N   1 
ATOM   1621 C CA  . LEU B 2 6   ? 52.133 85.677  38.332  1.00 32.65  ? 4   LEU L CA  1 
ATOM   1622 C C   . LEU B 2 6   ? 52.035 86.920  37.463  1.00 32.82  ? 4   LEU L C   1 
ATOM   1623 O O   . LEU B 2 6   ? 51.503 86.860  36.370  1.00 33.86  ? 4   LEU L O   1 
ATOM   1624 C CB  . LEU B 2 6   ? 52.839 84.553  37.573  1.00 31.23  ? 4   LEU L CB  1 
ATOM   1625 C CG  . LEU B 2 6   ? 53.099 83.213  38.268  1.00 30.63  ? 4   LEU L CG  1 
ATOM   1626 C CD1 . LEU B 2 6   ? 53.753 82.257  37.298  1.00 28.67  ? 4   LEU L CD1 1 
ATOM   1627 C CD2 . LEU B 2 6   ? 53.978 83.356  39.502  1.00 31.36  ? 4   LEU L CD2 1 
ATOM   1628 N N   . THR B 2 7   ? 52.517 88.043  37.965  1.00 34.38  ? 5   THR L N   1 
ATOM   1629 C CA  . THR B 2 7   ? 52.437 89.304  37.253  1.00 34.83  ? 5   THR L CA  1 
ATOM   1630 C C   . THR B 2 7   ? 53.815 89.633  36.665  1.00 33.23  ? 5   THR L C   1 
ATOM   1631 O O   . THR B 2 7   ? 54.817 89.738  37.390  1.00 29.76  ? 5   THR L O   1 
ATOM   1632 C CB  . THR B 2 7   ? 51.948 90.428  38.186  1.00 36.78  ? 5   THR L CB  1 
ATOM   1633 O OG1 . THR B 2 7   ? 50.699 90.048  38.740  1.00 43.19  ? 5   THR L OG1 1 
ATOM   1634 C CG2 . THR B 2 7   ? 51.720 91.718  37.438  1.00 38.70  ? 5   THR L CG2 1 
ATOM   1635 N N   . GLN B 2 8   ? 53.852 89.788  35.345  1.00 33.17  ? 6   GLN L N   1 
ATOM   1636 C CA  . GLN B 2 8   ? 55.055 90.207  34.635  1.00 34.18  ? 6   GLN L CA  1 
ATOM   1637 C C   . GLN B 2 8   ? 55.063 91.690  34.376  1.00 36.07  ? 6   GLN L C   1 
ATOM   1638 O O   . GLN B 2 8   ? 54.019 92.288  34.161  1.00 40.03  ? 6   GLN L O   1 
ATOM   1639 C CB  . GLN B 2 8   ? 55.179 89.492  33.306  1.00 34.22  ? 6   GLN L CB  1 
ATOM   1640 C CG  . GLN B 2 8   ? 55.515 88.019  33.492  1.00 34.13  ? 6   GLN L CG  1 
ATOM   1641 C CD  . GLN B 2 8   ? 55.724 87.270  32.190  1.00 33.95  ? 6   GLN L CD  1 
ATOM   1642 O OE1 . GLN B 2 8   ? 55.214 86.165  32.039  1.00 34.20  ? 6   GLN L OE1 1 
ATOM   1643 N NE2 . GLN B 2 8   ? 56.491 87.841  31.259  1.00 32.96  ? 6   GLN L NE2 1 
ATOM   1644 N N   . SER B 2 9   ? 56.256 92.273  34.400  1.00 36.40  ? 7   SER L N   1 
ATOM   1645 C CA  . SER B 2 9   ? 56.447 93.639  33.980  1.00 37.09  ? 7   SER L CA  1 
ATOM   1646 C C   . SER B 2 9   ? 57.810 93.781  33.317  1.00 36.75  ? 7   SER L C   1 
ATOM   1647 O O   . SER B 2 9   ? 58.766 93.116  33.713  1.00 34.88  ? 7   SER L O   1 
ATOM   1648 C CB  . SER B 2 9   ? 56.340 94.614  35.147  1.00 37.73  ? 7   SER L CB  1 
ATOM   1649 O OG  . SER B 2 9   ? 57.382 94.390  36.066  1.00 42.05  ? 7   SER L OG  1 
ATOM   1650 N N   . PRO B 2 10  ? 57.895 94.621  32.287  1.00 37.63  ? 8   PRO L N   1 
ATOM   1651 C CA  . PRO B 2 10  ? 56.740 95.305  31.729  1.00 35.97  ? 8   PRO L CA  1 
ATOM   1652 C C   . PRO B 2 10  ? 56.081 94.405  30.686  1.00 39.08  ? 8   PRO L C   1 
ATOM   1653 O O   . PRO B 2 10  ? 56.415 93.231  30.578  1.00 40.49  ? 8   PRO L O   1 
ATOM   1654 C CB  . PRO B 2 10  ? 57.356 96.530  31.102  1.00 36.15  ? 8   PRO L CB  1 
ATOM   1655 C CG  . PRO B 2 10  ? 58.672 96.048  30.620  1.00 37.48  ? 8   PRO L CG  1 
ATOM   1656 C CD  . PRO B 2 10  ? 59.115 94.937  31.533  1.00 36.83  ? 8   PRO L CD  1 
ATOM   1657 N N   . LEU B 2 11  ? 55.130 94.945  29.947  1.00 41.82  ? 9   LEU L N   1 
ATOM   1658 C CA  . LEU B 2 11  ? 54.440 94.200  28.913  1.00 44.07  ? 9   LEU L CA  1 
ATOM   1659 C C   . LEU B 2 11  ? 55.311 93.983  27.728  1.00 40.10  ? 9   LEU L C   1 
ATOM   1660 O O   . LEU B 2 11  ? 55.364 92.893  27.158  1.00 39.06  ? 9   LEU L O   1 
ATOM   1661 C CB  . LEU B 2 11  ? 53.251 94.988  28.378  1.00 48.34  ? 9   LEU L CB  1 
ATOM   1662 C CG  . LEU B 2 11  ? 51.874 94.531  28.762  1.00 53.21  ? 9   LEU L CG  1 
ATOM   1663 C CD1 . LEU B 2 11  ? 51.707 94.751  30.249  1.00 55.77  ? 9   LEU L CD1 1 
ATOM   1664 C CD2 . LEU B 2 11  ? 50.862 95.329  27.966  1.00 56.87  ? 9   LEU L CD2 1 
ATOM   1665 N N   . SER B 2 12  ? 55.897 95.071  27.279  1.00 39.05  ? 10  SER L N   1 
ATOM   1666 C CA  . SER B 2 12  ? 56.728 95.018  26.102  1.00 39.02  ? 10  SER L CA  1 
ATOM   1667 C C   . SER B 2 12  ? 57.956 95.730  26.514  1.00 38.07  ? 10  SER L C   1 
ATOM   1668 O O   . SER B 2 12  ? 57.857 96.749  27.222  1.00 43.94  ? 10  SER L O   1 
ATOM   1669 C CB  . SER B 2 12  ? 56.064 95.716  24.936  1.00 38.88  ? 10  SER L CB  1 
ATOM   1670 O OG  . SER B 2 12  ? 56.276 97.096  25.014  1.00 37.78  ? 10  SER L OG  1 
ATOM   1671 N N   . LEU B 2 13  ? 59.100 95.197  26.098  1.00 34.02  ? 11  LEU L N   1 
ATOM   1672 C CA  . LEU B 2 13  ? 60.390 95.749  26.460  1.00 34.79  ? 11  LEU L CA  1 
ATOM   1673 C C   . LEU B 2 13  ? 61.255 96.000  25.243  1.00 35.64  ? 11  LEU L C   1 
ATOM   1674 O O   . LEU B 2 13  ? 61.838 95.054  24.707  1.00 30.91  ? 11  LEU L O   1 
ATOM   1675 C CB  . LEU B 2 13  ? 61.116 94.768  27.379  1.00 36.58  ? 11  LEU L CB  1 
ATOM   1676 C CG  . LEU B 2 13  ? 62.492 95.171  27.902  1.00 39.45  ? 11  LEU L CG  1 
ATOM   1677 C CD1 . LEU B 2 13  ? 62.520 96.601  28.468  1.00 40.65  ? 11  LEU L CD1 1 
ATOM   1678 C CD2 . LEU B 2 13  ? 62.924 94.145  28.942  1.00 40.20  ? 11  LEU L CD2 1 
ATOM   1679 N N   . PRO B 2 14  ? 61.379 97.267  24.814  1.00 35.87  ? 12  PRO L N   1 
ATOM   1680 C CA  . PRO B 2 14  ? 62.290 97.478  23.696  1.00 39.38  ? 12  PRO L CA  1 
ATOM   1681 C C   . PRO B 2 14  ? 63.758 97.494  24.166  1.00 39.79  ? 12  PRO L C   1 
ATOM   1682 O O   . PRO B 2 14  ? 64.063 98.197  25.129  1.00 43.94  ? 12  PRO L O   1 
ATOM   1683 C CB  . PRO B 2 14  ? 61.820 98.816  23.097  1.00 38.03  ? 12  PRO L CB  1 
ATOM   1684 C CG  . PRO B 2 14  ? 61.145 99.531  24.211  1.00 39.50  ? 12  PRO L CG  1 
ATOM   1685 C CD  . PRO B 2 14  ? 60.747 98.516  25.265  1.00 37.93  ? 12  PRO L CD  1 
ATOM   1686 N N   . VAL B 2 15  ? 64.619 96.696  23.506  1.00 39.60  ? 13  VAL L N   1 
ATOM   1687 C CA  . VAL B 2 15  ? 66.098 96.676  23.724  1.00 41.16  ? 13  VAL L CA  1 
ATOM   1688 C C   . VAL B 2 15  ? 66.958 96.776  22.447  1.00 42.77  ? 13  VAL L C   1 
ATOM   1689 O O   . VAL B 2 15  ? 66.623 96.223  21.390  1.00 41.45  ? 13  VAL L O   1 
ATOM   1690 C CB  . VAL B 2 15  ? 66.594 95.395  24.447  1.00 40.59  ? 13  VAL L CB  1 
ATOM   1691 C CG1 . VAL B 2 15  ? 66.210 95.431  25.905  1.00 41.91  ? 13  VAL L CG1 1 
ATOM   1692 C CG2 . VAL B 2 15  ? 66.078 94.126  23.773  1.00 40.58  ? 13  VAL L CG2 1 
ATOM   1693 N N   . SER B 2 16  ? 68.095 97.446  22.553  1.00 46.68  ? 14  SER L N   1 
ATOM   1694 C CA  . SER B 2 16  ? 69.093 97.379  21.481  1.00 49.70  ? 14  SER L CA  1 
ATOM   1695 C C   . SER B 2 16  ? 69.659 95.945  21.401  1.00 47.30  ? 14  SER L C   1 
ATOM   1696 O O   . SER B 2 16  ? 69.904 95.313  22.433  1.00 45.13  ? 14  SER L O   1 
ATOM   1697 C CB  . SER B 2 16  ? 70.202 98.400  21.709  1.00 49.46  ? 14  SER L CB  1 
ATOM   1698 O OG  . SER B 2 16  ? 69.671 99.727  21.699  1.00 57.35  ? 14  SER L OG  1 
ATOM   1699 N N   . LEU B 2 17  ? 69.819 95.429  20.183  1.00 43.40  ? 15  LEU L N   1 
ATOM   1700 C CA  . LEU B 2 17  ? 70.400 94.122  19.994  1.00 45.89  ? 15  LEU L CA  1 
ATOM   1701 C C   . LEU B 2 17  ? 71.835 94.209  20.413  1.00 49.47  ? 15  LEU L C   1 
ATOM   1702 O O   . LEU B 2 17  ? 72.559 95.075  19.932  1.00 54.65  ? 15  LEU L O   1 
ATOM   1703 C CB  . LEU B 2 17  ? 70.351 93.667  18.535  1.00 46.08  ? 15  LEU L CB  1 
ATOM   1704 C CG  . LEU B 2 17  ? 69.060 93.104  17.920  1.00 44.10  ? 15  LEU L CG  1 
ATOM   1705 C CD1 . LEU B 2 17  ? 69.424 92.463  16.591  1.00 44.08  ? 15  LEU L CD1 1 
ATOM   1706 C CD2 . LEU B 2 17  ? 68.320 92.095  18.796  1.00 43.18  ? 15  LEU L CD2 1 
ATOM   1707 N N   . GLY B 2 18  ? 72.229 93.316  21.317  1.00 52.07  ? 16  GLY L N   1 
ATOM   1708 C CA  . GLY B 2 18  ? 73.582 93.288  21.869  1.00 49.67  ? 16  GLY L CA  1 
ATOM   1709 C C   . GLY B 2 18  ? 73.695 93.888  23.259  1.00 48.76  ? 16  GLY L C   1 
ATOM   1710 O O   . GLY B 2 18  ? 74.777 93.918  23.820  1.00 48.31  ? 16  GLY L O   1 
ATOM   1711 N N   . ASP B 2 19  ? 72.577 94.352  23.810  1.00 47.74  ? 17  ASP L N   1 
ATOM   1712 C CA  . ASP B 2 19  ? 72.505 94.960  25.142  1.00 48.11  ? 17  ASP L CA  1 
ATOM   1713 C C   . ASP B 2 19  ? 71.924 93.899  26.101  1.00 44.87  ? 17  ASP L C   1 
ATOM   1714 O O   . ASP B 2 19  ? 71.647 92.767  25.694  1.00 44.63  ? 17  ASP L O   1 
ATOM   1715 C CB  . ASP B 2 19  ? 71.649 96.256  25.022  1.00 53.02  ? 17  ASP L CB  1 
ATOM   1716 C CG  . ASP B 2 19  ? 71.193 96.858  26.359  1.00 57.05  ? 17  ASP L CG  1 
ATOM   1717 O OD1 . ASP B 2 19  ? 71.925 96.829  27.378  1.00 59.49  ? 17  ASP L OD1 1 
ATOM   1718 O OD2 . ASP B 2 19  ? 70.075 97.404  26.371  1.00 64.17  ? 17  ASP L OD2 1 
ATOM   1719 N N   . GLN B 2 20  ? 71.833 94.267  27.374  1.00 42.11  ? 18  GLN L N   1 
ATOM   1720 C CA  . GLN B 2 20  ? 71.101 93.535  28.388  1.00 44.12  ? 18  GLN L CA  1 
ATOM   1721 C C   . GLN B 2 20  ? 69.614 93.837  28.415  1.00 40.52  ? 18  GLN L C   1 
ATOM   1722 O O   . GLN B 2 20  ? 69.206 94.973  28.232  1.00 41.00  ? 18  GLN L O   1 
ATOM   1723 C CB  . GLN B 2 20  ? 71.611 93.900  29.775  1.00 46.39  ? 18  GLN L CB  1 
ATOM   1724 C CG  . GLN B 2 20  ? 73.062 93.556  30.022  1.00 52.38  ? 18  GLN L CG  1 
ATOM   1725 C CD  . GLN B 2 20  ? 73.317 93.156  31.462  1.00 57.14  ? 18  GLN L CD  1 
ATOM   1726 O OE1 . GLN B 2 20  ? 72.541 93.498  32.371  1.00 59.73  ? 18  GLN L OE1 1 
ATOM   1727 N NE2 . GLN B 2 20  ? 74.407 92.426  31.685  1.00 55.99  ? 18  GLN L NE2 1 
ATOM   1728 N N   . ALA B 2 21  ? 68.831 92.820  28.747  1.00 36.89  ? 19  ALA L N   1 
ATOM   1729 C CA  . ALA B 2 21  ? 67.381 92.943  28.982  1.00 37.43  ? 19  ALA L CA  1 
ATOM   1730 C C   . ALA B 2 21  ? 67.100 92.315  30.334  1.00 35.02  ? 19  ALA L C   1 
ATOM   1731 O O   . ALA B 2 21  ? 67.699 91.302  30.663  1.00 32.03  ? 19  ALA L O   1 
ATOM   1732 C CB  . ALA B 2 21  ? 66.595 92.203  27.897  1.00 36.07  ? 19  ALA L CB  1 
ATOM   1733 N N   . SER B 2 22  ? 66.205 92.887  31.125  1.00 35.85  ? 20  SER L N   1 
ATOM   1734 C CA  . SER B 2 22  ? 65.705 92.125  32.286  1.00 37.85  ? 20  SER L CA  1 
ATOM   1735 C C   . SER B 2 22  ? 64.191 92.238  32.484  1.00 37.02  ? 20  SER L C   1 
ATOM   1736 O O   . SER B 2 22  ? 63.596 93.284  32.269  1.00 41.11  ? 20  SER L O   1 
ATOM   1737 C CB  . SER B 2 22  ? 66.503 92.413  33.550  1.00 38.33  ? 20  SER L CB  1 
ATOM   1738 O OG  . SER B 2 22  ? 66.304 93.739  33.978  1.00 44.26  ? 20  SER L OG  1 
ATOM   1739 N N   . ILE B 2 23  ? 63.585 91.118  32.857  1.00 37.40  ? 21  ILE L N   1 
ATOM   1740 C CA  . ILE B 2 23  ? 62.129 90.961  32.897  1.00 37.78  ? 21  ILE L CA  1 
ATOM   1741 C C   . ILE B 2 23  ? 61.750 90.478  34.286  1.00 37.62  ? 21  ILE L C   1 
ATOM   1742 O O   . ILE B 2 23  ? 62.367 89.547  34.808  1.00 39.91  ? 21  ILE L O   1 
ATOM   1743 C CB  . ILE B 2 23  ? 61.614 89.929  31.868  1.00 36.48  ? 21  ILE L CB  1 
ATOM   1744 C CG1 . ILE B 2 23  ? 61.923 90.414  30.454  1.00 38.30  ? 21  ILE L CG1 1 
ATOM   1745 C CG2 . ILE B 2 23  ? 60.105 89.709  32.033  1.00 38.53  ? 21  ILE L CG2 1 
ATOM   1746 C CD1 . ILE B 2 23  ? 61.529 89.465  29.338  1.00 38.45  ? 21  ILE L CD1 1 
ATOM   1747 N N   . SER B 2 24  ? 60.703 91.082  34.844  1.00 35.00  ? 22  SER L N   1 
ATOM   1748 C CA  . SER B 2 24  ? 60.293 90.803  36.194  1.00 34.42  ? 22  SER L CA  1 
ATOM   1749 C C   . SER B 2 24  ? 59.031 89.948  36.189  1.00 34.77  ? 22  SER L C   1 
ATOM   1750 O O   . SER B 2 24  ? 58.180 90.090  35.320  1.00 32.45  ? 22  SER L O   1 
ATOM   1751 C CB  . SER B 2 24  ? 60.052 92.095  36.930  1.00 35.15  ? 22  SER L CB  1 
ATOM   1752 O OG  . SER B 2 24  ? 59.264 91.844  38.068  1.00 36.41  ? 22  SER L OG  1 
ATOM   1753 N N   . CYS B 2 25  ? 58.946 89.039  37.151  1.00 34.20  ? 23  CYS L N   1 
ATOM   1754 C CA  . CYS B 2 25  ? 57.764 88.210  37.339  1.00 33.06  ? 23  CYS L CA  1 
ATOM   1755 C C   . CYS B 2 25  ? 57.550 88.193  38.821  1.00 32.64  ? 23  CYS L C   1 
ATOM   1756 O O   . CYS B 2 25  ? 58.431 87.769  39.552  1.00 35.78  ? 23  CYS L O   1 
ATOM   1757 C CB  . CYS B 2 25  ? 57.990 86.797  36.820  1.00 32.59  ? 23  CYS L CB  1 
ATOM   1758 S SG  . CYS B 2 25  ? 56.637 85.633  37.129  1.00 32.63  ? 23  CYS L SG  1 
ATOM   1759 N N   . THR B 2 26  ? 56.393 88.691  39.243  1.00 32.77  ? 24  THR L N   1 
ATOM   1760 C CA  . THR B 2 26  ? 55.995 88.804  40.643  1.00 34.03  ? 24  THR L CA  1 
ATOM   1761 C C   . THR B 2 26  ? 54.877 87.829  40.962  1.00 34.66  ? 24  THR L C   1 
ATOM   1762 O O   . THR B 2 26  ? 53.822 87.863  40.316  1.00 35.26  ? 24  THR L O   1 
ATOM   1763 C CB  . THR B 2 26  ? 55.479 90.213  40.953  1.00 34.74  ? 24  THR L CB  1 
ATOM   1764 O OG1 . THR B 2 26  ? 56.576 91.109  40.872  1.00 38.32  ? 24  THR L OG1 1 
ATOM   1765 C CG2 . THR B 2 26  ? 54.929 90.301  42.349  1.00 38.53  ? 24  THR L CG2 1 
ATOM   1766 N N   . SER B 2 27  ? 55.098 87.015  41.992  1.00 31.82  ? 25  SER L N   1 
ATOM   1767 C CA  . SER B 2 27  ? 54.176 85.974  42.394  1.00 29.98  ? 25  SER L CA  1 
ATOM   1768 C C   . SER B 2 27  ? 53.301 86.433  43.550  1.00 30.59  ? 25  SER L C   1 
ATOM   1769 O O   . SER B 2 27  ? 53.789 87.020  44.507  1.00 31.38  ? 25  SER L O   1 
ATOM   1770 C CB  . SER B 2 27  ? 54.951 84.737  42.820  1.00 29.42  ? 25  SER L CB  1 
ATOM   1771 O OG  . SER B 2 27  ? 54.053 83.705  43.078  1.00 29.32  ? 25  SER L OG  1 
ATOM   1772 N N   . SER B 2 28  ? 52.010 86.116  43.485  1.00 32.00  ? 26  SER L N   1 
ATOM   1773 C CA  . SER B 2 28  ? 51.074 86.518  44.537  1.00 33.01  ? 26  SER L CA  1 
ATOM   1774 C C   . SER B 2 28  ? 51.367 85.785  45.837  1.00 36.57  ? 26  SER L C   1 
ATOM   1775 O O   . SER B 2 28  ? 50.965 86.255  46.904  1.00 37.21  ? 26  SER L O   1 
ATOM   1776 C CB  . SER B 2 28  ? 49.626 86.278  44.132  1.00 31.86  ? 26  SER L CB  1 
ATOM   1777 O OG  . SER B 2 28  ? 49.301 84.895  44.123  1.00 31.59  ? 26  SER L OG  1 
ATOM   1778 N N   . GLN B 2 29  ? 52.043 84.634  45.739  1.00 37.96  ? 27  GLN L N   1 
ATOM   1779 C CA  . GLN B 2 29  ? 52.534 83.925  46.910  1.00 35.54  ? 27  GLN L CA  1 
ATOM   1780 C C   . GLN B 2 29  ? 53.965 83.429  46.774  1.00 31.30  ? 27  GLN L C   1 
ATOM   1781 O O   . GLN B 2 29  ? 54.554 83.459  45.708  1.00 30.72  ? 27  GLN L O   1 
ATOM   1782 C CB  . GLN B 2 29  ? 51.588 82.766  47.269  1.00 39.63  ? 27  GLN L CB  1 
ATOM   1783 C CG  . GLN B 2 29  ? 50.618 83.108  48.402  1.00 44.26  ? 27  GLN L CG  1 
ATOM   1784 C CD  . GLN B 2 29  ? 51.309 83.634  49.666  1.00 46.74  ? 27  GLN L CD  1 
ATOM   1785 O OE1 . GLN B 2 29  ? 52.425 83.214  50.043  1.00 44.83  ? 27  GLN L OE1 1 
ATOM   1786 N NE2 . GLN B 2 29  ? 50.651 84.573  50.322  1.00 52.15  ? 27  GLN L NE2 1 
ATOM   1787 N N   . SER B 2 30  A 54.508 83.016  47.912  1.00 30.16  ? 27  SER L N   1 
ATOM   1788 C CA  . SER B 2 30  A 55.801 82.347  48.008  1.00 30.74  ? 27  SER L CA  1 
ATOM   1789 C C   . SER B 2 30  A 55.776 81.084  47.194  1.00 28.71  ? 27  SER L C   1 
ATOM   1790 O O   . SER B 2 30  A 54.828 80.332  47.286  1.00 27.95  ? 27  SER L O   1 
ATOM   1791 C CB  . SER B 2 30  A 56.113 81.960  49.450  1.00 29.94  ? 27  SER L CB  1 
ATOM   1792 O OG  . SER B 2 30  A 57.506 81.740  49.558  1.00 30.49  ? 27  SER L OG  1 
ATOM   1793 N N   . LEU B 2 31  B 56.817 80.884  46.401  1.00 27.77  ? 27  LEU L N   1 
ATOM   1794 C CA  . LEU B 2 31  B 56.975 79.690  45.562  1.00 28.50  ? 27  LEU L CA  1 
ATOM   1795 C C   . LEU B 2 31  B 58.067 78.750  46.048  1.00 29.57  ? 27  LEU L C   1 
ATOM   1796 O O   . LEU B 2 31  B 58.419 77.799  45.344  1.00 31.54  ? 27  LEU L O   1 
ATOM   1797 C CB  . LEU B 2 31  B 57.318 80.120  44.142  1.00 27.75  ? 27  LEU L CB  1 
ATOM   1798 C CG  . LEU B 2 31  B 56.365 81.089  43.465  1.00 26.24  ? 27  LEU L CG  1 
ATOM   1799 C CD1 . LEU B 2 31  B 56.853 81.283  42.047  1.00 26.15  ? 27  LEU L CD1 1 
ATOM   1800 C CD2 . LEU B 2 31  B 54.962 80.532  43.468  1.00 25.80  ? 27  LEU L CD2 1 
ATOM   1801 N N   . LEU B 2 32  C 58.609 79.029  47.237  1.00 30.02  ? 27  LEU L N   1 
ATOM   1802 C CA  . LEU B 2 32  C 59.620 78.206  47.841  1.00 29.31  ? 27  LEU L CA  1 
ATOM   1803 C C   . LEU B 2 32  C 59.001 76.916  48.375  1.00 27.23  ? 27  LEU L C   1 
ATOM   1804 O O   . LEU B 2 32  C 58.267 76.934  49.349  1.00 29.26  ? 27  LEU L O   1 
ATOM   1805 C CB  . LEU B 2 32  C 60.328 78.985  48.967  1.00 31.08  ? 27  LEU L CB  1 
ATOM   1806 C CG  . LEU B 2 32  C 61.383 78.178  49.755  1.00 34.13  ? 27  LEU L CG  1 
ATOM   1807 C CD1 . LEU B 2 32  C 62.578 77.734  48.907  1.00 32.39  ? 27  LEU L CD1 1 
ATOM   1808 C CD2 . LEU B 2 32  C 61.856 78.952  50.974  1.00 34.45  ? 27  LEU L CD2 1 
ATOM   1809 N N   . HIS B 2 33  D 59.317 75.798  47.735  1.00 26.94  ? 27  HIS L N   1 
ATOM   1810 C CA  . HIS B 2 33  D 58.889 74.475  48.190  1.00 27.37  ? 27  HIS L CA  1 
ATOM   1811 C C   . HIS B 2 33  D 59.698 74.003  49.391  1.00 27.70  ? 27  HIS L C   1 
ATOM   1812 O O   . HIS B 2 33  D 60.901 74.221  49.460  1.00 29.56  ? 27  HIS L O   1 
ATOM   1813 C CB  . HIS B 2 33  D 59.091 73.482  47.043  1.00 28.13  ? 27  HIS L CB  1 
ATOM   1814 C CG  . HIS B 2 33  D 58.356 72.199  47.219  1.00 30.10  ? 27  HIS L CG  1 
ATOM   1815 N ND1 . HIS B 2 33  D 58.807 71.186  48.029  1.00 32.23  ? 27  HIS L ND1 1 
ATOM   1816 C CD2 . HIS B 2 33  D 57.202 71.749  46.674  1.00 33.31  ? 27  HIS L CD2 1 
ATOM   1817 C CE1 . HIS B 2 33  D 57.976 70.160  47.977  1.00 32.53  ? 27  HIS L CE1 1 
ATOM   1818 N NE2 . HIS B 2 33  D 56.996 70.472  47.152  1.00 33.06  ? 27  HIS L NE2 1 
ATOM   1819 N N   . SER B 2 34  E 59.074 73.263  50.288  1.00 30.28  ? 27  SER L N   1 
ATOM   1820 C CA  . SER B 2 34  E 59.767 72.651  51.466  1.00 30.90  ? 27  SER L CA  1 
ATOM   1821 C C   . SER B 2 34  E 61.015 71.742  51.211  1.00 29.01  ? 27  SER L C   1 
ATOM   1822 O O   . SER B 2 34  E 61.781 71.457  52.124  1.00 26.26  ? 27  SER L O   1 
ATOM   1823 C CB  . SER B 2 34  E 58.741 71.829  52.219  1.00 31.68  ? 27  SER L CB  1 
ATOM   1824 O OG  . SER B 2 34  E 58.138 70.928  51.299  1.00 35.85  ? 27  SER L OG  1 
ATOM   1825 N N   . ASN B 2 35  ? 61.206 71.288  49.977  1.00 26.66  ? 28  ASN L N   1 
ATOM   1826 C CA  . ASN B 2 35  ? 62.405 70.561  49.591  1.00 27.80  ? 28  ASN L CA  1 
ATOM   1827 C C   . ASN B 2 35  ? 63.590 71.498  49.262  1.00 30.62  ? 28  ASN L C   1 
ATOM   1828 O O   . ASN B 2 35  ? 64.679 71.018  48.975  1.00 31.62  ? 28  ASN L O   1 
ATOM   1829 C CB  . ASN B 2 35  ? 62.106 69.581  48.445  1.00 27.84  ? 28  ASN L CB  1 
ATOM   1830 C CG  . ASN B 2 35  ? 61.771 70.262  47.131  1.00 25.55  ? 28  ASN L CG  1 
ATOM   1831 O OD1 . ASN B 2 35  ? 61.933 71.466  46.966  1.00 27.28  ? 28  ASN L OD1 1 
ATOM   1832 N ND2 . ASN B 2 35  ? 61.306 69.483  46.192  1.00 23.62  ? 28  ASN L ND2 1 
ATOM   1833 N N   . GLY B 2 36  ? 63.340 72.819  49.280  1.00 31.54  ? 29  GLY L N   1 
ATOM   1834 C CA  . GLY B 2 36  ? 64.332 73.861  49.051  1.00 30.68  ? 29  GLY L CA  1 
ATOM   1835 C C   . GLY B 2 36  ? 64.353 74.410  47.619  1.00 30.47  ? 29  GLY L C   1 
ATOM   1836 O O   . GLY B 2 36  ? 64.980 75.430  47.350  1.00 29.78  ? 29  GLY L O   1 
ATOM   1837 N N   . ASP B 2 37  ? 63.689 73.734  46.690  1.00 28.57  ? 30  ASP L N   1 
ATOM   1838 C CA  . ASP B 2 37  ? 63.607 74.231  45.327  1.00 27.53  ? 30  ASP L CA  1 
ATOM   1839 C C   . ASP B 2 37  ? 62.512 75.273  45.205  1.00 27.72  ? 30  ASP L C   1 
ATOM   1840 O O   . ASP B 2 37  ? 61.515 75.226  45.923  1.00 28.23  ? 30  ASP L O   1 
ATOM   1841 C CB  . ASP B 2 37  ? 63.272 73.097  44.393  1.00 28.49  ? 30  ASP L CB  1 
ATOM   1842 C CG  . ASP B 2 37  ? 64.421 72.111  44.193  1.00 29.07  ? 30  ASP L CG  1 
ATOM   1843 O OD1 . ASP B 2 37  ? 65.603 72.396  44.497  1.00 29.65  ? 30  ASP L OD1 1 
ATOM   1844 O OD2 . ASP B 2 37  ? 64.109 71.035  43.662  1.00 30.77  ? 30  ASP L OD2 1 
ATOM   1845 N N   . THR B 2 38  ? 62.694 76.196  44.266  1.00 26.86  ? 31  THR L N   1 
ATOM   1846 C CA  . THR B 2 38  ? 61.717 77.217  43.967  1.00 27.64  ? 31  THR L CA  1 
ATOM   1847 C C   . THR B 2 38  ? 61.348 76.999  42.511  1.00 27.77  ? 31  THR L C   1 
ATOM   1848 O O   . THR B 2 38  ? 62.211 77.136  41.641  1.00 28.26  ? 31  THR L O   1 
ATOM   1849 C CB  . THR B 2 38  ? 62.314 78.593  44.247  1.00 28.74  ? 31  THR L CB  1 
ATOM   1850 O OG1 . THR B 2 38  ? 62.515 78.707  45.652  1.00 30.86  ? 31  THR L OG1 1 
ATOM   1851 C CG2 . THR B 2 38  ? 61.386 79.732  43.814  1.00 29.95  ? 31  THR L CG2 1 
ATOM   1852 N N   . TYR B 2 39  ? 60.086 76.621  42.263  1.00 25.72  ? 32  TYR L N   1 
ATOM   1853 C CA  . TYR B 2 39  ? 59.641 76.079  40.956  1.00 25.59  ? 32  TYR L CA  1 
ATOM   1854 C C   . TYR B 2 39  ? 59.016 77.124  40.038  1.00 25.97  ? 32  TYR L C   1 
ATOM   1855 O O   . TYR B 2 39  ? 57.827 77.095  39.674  1.00 24.82  ? 32  TYR L O   1 
ATOM   1856 C CB  . TYR B 2 39  ? 58.687 74.917  41.166  1.00 25.55  ? 32  TYR L CB  1 
ATOM   1857 C CG  . TYR B 2 39  ? 59.347 73.697  41.741  1.00 25.31  ? 32  TYR L CG  1 
ATOM   1858 C CD1 . TYR B 2 39  ? 60.194 72.922  40.970  1.00 26.81  ? 32  TYR L CD1 1 
ATOM   1859 C CD2 . TYR B 2 39  ? 59.112 73.305  43.061  1.00 26.34  ? 32  TYR L CD2 1 
ATOM   1860 C CE1 . TYR B 2 39  ? 60.803 71.774  41.492  1.00 27.55  ? 32  TYR L CE1 1 
ATOM   1861 C CE2 . TYR B 2 39  ? 59.706 72.165  43.596  1.00 27.16  ? 32  TYR L CE2 1 
ATOM   1862 C CZ  . TYR B 2 39  ? 60.541 71.399  42.810  1.00 27.96  ? 32  TYR L CZ  1 
ATOM   1863 O OH  . TYR B 2 39  ? 61.139 70.289  43.348  1.00 29.35  ? 32  TYR L OH  1 
ATOM   1864 N N   . LEU B 2 40  ? 59.881 78.059  39.696  1.00 25.43  ? 33  LEU L N   1 
ATOM   1865 C CA  . LEU B 2 40  ? 59.587 79.208  38.903  1.00 25.22  ? 33  LEU L CA  1 
ATOM   1866 C C   . LEU B 2 40  ? 60.431 79.078  37.656  1.00 25.56  ? 33  LEU L C   1 
ATOM   1867 O O   . LEU B 2 40  ? 61.675 79.053  37.744  1.00 29.00  ? 33  LEU L O   1 
ATOM   1868 C CB  . LEU B 2 40  ? 59.961 80.480  39.671  1.00 25.15  ? 33  LEU L CB  1 
ATOM   1869 C CG  . LEU B 2 40  ? 59.666 81.863  39.064  1.00 24.34  ? 33  LEU L CG  1 
ATOM   1870 C CD1 . LEU B 2 40  ? 60.645 82.232  37.959  1.00 23.81  ? 33  LEU L CD1 1 
ATOM   1871 C CD2 . LEU B 2 40  ? 58.216 81.982  38.591  1.00 24.99  ? 33  LEU L CD2 1 
ATOM   1872 N N   . HIS B 2 41  ? 59.753 79.042  36.511  1.00 24.60  ? 34  HIS L N   1 
ATOM   1873 C CA  . HIS B 2 41  ? 60.352 78.790  35.216  1.00 25.39  ? 34  HIS L CA  1 
ATOM   1874 C C   . HIS B 2 41  ? 60.064 79.916  34.231  1.00 25.47  ? 34  HIS L C   1 
ATOM   1875 O O   . HIS B 2 41  ? 59.078 80.599  34.376  1.00 27.60  ? 34  HIS L O   1 
ATOM   1876 C CB  . HIS B 2 41  ? 59.777 77.492  34.649  1.00 27.52  ? 34  HIS L CB  1 
ATOM   1877 C CG  . HIS B 2 41  ? 59.409 76.493  35.701  1.00 27.85  ? 34  HIS L CG  1 
ATOM   1878 N ND1 . HIS B 2 41  ? 60.358 75.782  36.398  1.00 28.62  ? 34  HIS L ND1 1 
ATOM   1879 C CD2 . HIS B 2 41  ? 58.212 76.138  36.222  1.00 27.15  ? 34  HIS L CD2 1 
ATOM   1880 C CE1 . HIS B 2 41  ? 59.765 74.988  37.268  1.00 29.11  ? 34  HIS L CE1 1 
ATOM   1881 N NE2 . HIS B 2 41  ? 58.462 75.207  37.205  1.00 29.51  ? 34  HIS L NE2 1 
ATOM   1882 N N   . TRP B 2 42  ? 60.910 80.054  33.208  1.00 24.83  ? 35  TRP L N   1 
ATOM   1883 C CA  . TRP B 2 42  ? 60.756 81.038  32.154  1.00 23.49  ? 35  TRP L CA  1 
ATOM   1884 C C   . TRP B 2 42  ? 60.793 80.376  30.807  1.00 23.60  ? 35  TRP L C   1 
ATOM   1885 O O   . TRP B 2 42  ? 61.714 79.627  30.517  1.00 22.96  ? 35  TRP L O   1 
ATOM   1886 C CB  . TRP B 2 42  ? 61.920 82.009  32.172  1.00 23.89  ? 35  TRP L CB  1 
ATOM   1887 C CG  . TRP B 2 42  ? 62.011 82.786  33.356  1.00 22.91  ? 35  TRP L CG  1 
ATOM   1888 C CD1 . TRP B 2 42  ? 62.646 82.444  34.512  1.00 23.62  ? 35  TRP L CD1 1 
ATOM   1889 C CD2 . TRP B 2 42  ? 61.467 84.091  33.555  1.00 24.07  ? 35  TRP L CD2 1 
ATOM   1890 N NE1 . TRP B 2 42  ? 62.528 83.463  35.438  1.00 22.95  ? 35  TRP L NE1 1 
ATOM   1891 C CE2 . TRP B 2 42  ? 61.823 84.494  34.872  1.00 22.74  ? 35  TRP L CE2 1 
ATOM   1892 C CE3 . TRP B 2 42  ? 60.715 84.971  32.752  1.00 23.57  ? 35  TRP L CE3 1 
ATOM   1893 C CZ2 . TRP B 2 42  ? 61.437 85.717  35.406  1.00 23.21  ? 35  TRP L CZ2 1 
ATOM   1894 C CZ3 . TRP B 2 42  ? 60.335 86.202  33.290  1.00 23.40  ? 35  TRP L CZ3 1 
ATOM   1895 C CH2 . TRP B 2 42  ? 60.696 86.558  34.606  1.00 23.72  ? 35  TRP L CH2 1 
ATOM   1896 N N   . TYR B 2 43  ? 59.843 80.719  29.944  1.00 24.42  ? 36  TYR L N   1 
ATOM   1897 C CA  . TYR B 2 43  ? 59.815 80.206  28.569  1.00 23.99  ? 36  TYR L CA  1 
ATOM   1898 C C   . TYR B 2 43  ? 59.911 81.379  27.648  1.00 25.22  ? 36  TYR L C   1 
ATOM   1899 O O   . TYR B 2 43  ? 59.672 82.491  28.054  1.00 27.88  ? 36  TYR L O   1 
ATOM   1900 C CB  . TYR B 2 43  ? 58.514 79.441  28.263  1.00 23.59  ? 36  TYR L CB  1 
ATOM   1901 C CG  . TYR B 2 43  ? 58.235 78.254  29.174  1.00 22.68  ? 36  TYR L CG  1 
ATOM   1902 C CD1 . TYR B 2 43  ? 57.962 78.443  30.523  1.00 21.65  ? 36  TYR L CD1 1 
ATOM   1903 C CD2 . TYR B 2 43  ? 58.172 76.952  28.679  1.00 22.51  ? 36  TYR L CD2 1 
ATOM   1904 C CE1 . TYR B 2 43  ? 57.648 77.398  31.363  1.00 20.26  ? 36  TYR L CE1 1 
ATOM   1905 C CE2 . TYR B 2 43  ? 57.869 75.884  29.533  1.00 21.59  ? 36  TYR L CE2 1 
ATOM   1906 C CZ  . TYR B 2 43  ? 57.631 76.129  30.887  1.00 20.67  ? 36  TYR L CZ  1 
ATOM   1907 O OH  . TYR B 2 43  ? 57.356 75.135  31.789  1.00 19.82  ? 36  TYR L OH  1 
ATOM   1908 N N   . LEU B 2 44  ? 60.262 81.114  26.401  1.00 27.52  ? 37  LEU L N   1 
ATOM   1909 C CA  . LEU B 2 44  ? 60.174 82.077  25.288  1.00 26.11  ? 37  LEU L CA  1 
ATOM   1910 C C   . LEU B 2 44  ? 59.241 81.488  24.229  1.00 25.50  ? 37  LEU L C   1 
ATOM   1911 O O   . LEU B 2 44  ? 59.380 80.339  23.878  1.00 25.61  ? 37  LEU L O   1 
ATOM   1912 C CB  . LEU B 2 44  ? 61.564 82.248  24.679  1.00 26.15  ? 37  LEU L CB  1 
ATOM   1913 C CG  . LEU B 2 44  ? 61.715 82.779  23.257  1.00 25.72  ? 37  LEU L CG  1 
ATOM   1914 C CD1 . LEU B 2 44  ? 61.241 84.217  23.212  1.00 27.62  ? 37  LEU L CD1 1 
ATOM   1915 C CD2 . LEU B 2 44  ? 63.162 82.685  22.799  1.00 26.02  ? 37  LEU L CD2 1 
ATOM   1916 N N   . GLN B 2 45  ? 58.293 82.256  23.732  1.00 25.86  ? 38  GLN L N   1 
ATOM   1917 C CA  . GLN B 2 45  ? 57.492 81.822  22.604  1.00 28.79  ? 38  GLN L CA  1 
ATOM   1918 C C   . GLN B 2 45  ? 57.755 82.748  21.401  1.00 31.37  ? 38  GLN L C   1 
ATOM   1919 O O   . GLN B 2 45  ? 57.554 83.958  21.483  1.00 30.19  ? 38  GLN L O   1 
ATOM   1920 C CB  . GLN B 2 45  ? 56.001 81.778  22.957  1.00 29.26  ? 38  GLN L CB  1 
ATOM   1921 C CG  . GLN B 2 45  ? 55.142 81.081  21.910  1.00 29.63  ? 38  GLN L CG  1 
ATOM   1922 C CD  . GLN B 2 45  ? 53.676 80.954  22.296  1.00 28.11  ? 38  GLN L CD  1 
ATOM   1923 O OE1 . GLN B 2 45  ? 53.160 81.665  23.156  1.00 28.20  ? 38  GLN L OE1 1 
ATOM   1924 N NE2 . GLN B 2 45  ? 53.001 80.056  21.641  1.00 27.10  ? 38  GLN L NE2 1 
ATOM   1925 N N   . LYS B 2 46  ? 58.232 82.143  20.310  1.00 35.64  ? 39  LYS L N   1 
ATOM   1926 C CA  . LYS B 2 46  ? 58.450 82.803  19.031  1.00 39.19  ? 39  LYS L CA  1 
ATOM   1927 C C   . LYS B 2 46  ? 57.174 82.736  18.187  1.00 39.20  ? 39  LYS L C   1 
ATOM   1928 O O   . LYS B 2 46  ? 56.392 81.769  18.292  1.00 37.12  ? 39  LYS L O   1 
ATOM   1929 C CB  . LYS B 2 46  ? 59.561 82.086  18.257  1.00 43.26  ? 39  LYS L CB  1 
ATOM   1930 C CG  . LYS B 2 46  ? 60.985 82.239  18.775  1.00 45.90  ? 39  LYS L CG  1 
ATOM   1931 C CD  . LYS B 2 46  ? 61.588 83.609  18.489  1.00 51.47  ? 39  LYS L CD  1 
ATOM   1932 C CE  . LYS B 2 46  ? 62.008 83.859  17.044  1.00 54.98  ? 39  LYS L CE  1 
ATOM   1933 N NZ  . LYS B 2 46  ? 62.391 85.296  16.854  1.00 55.19  ? 39  LYS L NZ  1 
ATOM   1934 N N   . PRO B 2 47  ? 56.977 83.728  17.297  1.00 41.04  ? 40  PRO L N   1 
ATOM   1935 C CA  . PRO B 2 47  ? 55.712 83.725  16.562  1.00 39.35  ? 40  PRO L CA  1 
ATOM   1936 C C   . PRO B 2 47  ? 55.515 82.421  15.797  1.00 37.60  ? 40  PRO L C   1 
ATOM   1937 O O   . PRO B 2 47  ? 56.476 81.909  15.234  1.00 37.47  ? 40  PRO L O   1 
ATOM   1938 C CB  . PRO B 2 47  ? 55.843 84.912  15.605  1.00 39.88  ? 40  PRO L CB  1 
ATOM   1939 C CG  . PRO B 2 47  ? 57.073 85.644  16.019  1.00 41.40  ? 40  PRO L CG  1 
ATOM   1940 C CD  . PRO B 2 47  ? 57.952 84.655  16.698  1.00 39.75  ? 40  PRO L CD  1 
ATOM   1941 N N   . GLY B 2 48  ? 54.293 81.882  15.846  1.00 39.39  ? 41  GLY L N   1 
ATOM   1942 C CA  . GLY B 2 48  ? 53.905 80.642  15.148  1.00 39.36  ? 41  GLY L CA  1 
ATOM   1943 C C   . GLY B 2 48  ? 54.632 79.387  15.602  1.00 39.53  ? 41  GLY L C   1 
ATOM   1944 O O   . GLY B 2 48  ? 54.853 78.469  14.822  1.00 38.25  ? 41  GLY L O   1 
ATOM   1945 N N   . GLN B 2 49  ? 55.007 79.361  16.872  1.00 39.13  ? 42  GLN L N   1 
ATOM   1946 C CA  . GLN B 2 49  ? 55.694 78.226  17.475  1.00 38.30  ? 42  GLN L CA  1 
ATOM   1947 C C   . GLN B 2 49  ? 55.252 78.108  18.903  1.00 34.08  ? 42  GLN L C   1 
ATOM   1948 O O   . GLN B 2 49  ? 54.707 79.028  19.494  1.00 32.95  ? 42  GLN L O   1 
ATOM   1949 C CB  . GLN B 2 49  ? 57.218 78.420  17.475  1.00 45.15  ? 42  GLN L CB  1 
ATOM   1950 C CG  . GLN B 2 49  ? 57.959 78.056  16.187  1.00 45.74  ? 42  GLN L CG  1 
ATOM   1951 C CD  . GLN B 2 49  ? 59.284 78.777  16.124  1.00 47.94  ? 42  GLN L CD  1 
ATOM   1952 O OE1 . GLN B 2 49  ? 60.034 78.787  17.107  1.00 46.16  ? 42  GLN L OE1 1 
ATOM   1953 N NE2 . GLN B 2 49  ? 59.563 79.434  14.988  1.00 52.89  ? 42  GLN L NE2 1 
ATOM   1954 N N   . SER B 2 50  ? 55.550 76.970  19.473  1.00 32.46  ? 43  SER L N   1 
ATOM   1955 C CA  . SER B 2 50  ? 55.140 76.717  20.803  1.00 32.85  ? 43  SER L CA  1 
ATOM   1956 C C   . SER B 2 50  ? 56.201 77.251  21.791  1.00 31.95  ? 43  SER L C   1 
ATOM   1957 O O   . SER B 2 50  ? 57.336 77.522  21.420  1.00 34.07  ? 43  SER L O   1 
ATOM   1958 C CB  . SER B 2 50  ? 54.909 75.224  20.952  1.00 34.49  ? 43  SER L CB  1 
ATOM   1959 O OG  . SER B 2 50  ? 56.137 74.566  21.041  1.00 41.20  ? 43  SER L OG  1 
ATOM   1960 N N   . PRO B 2 51  ? 55.838 77.391  23.067  1.00 29.88  ? 44  PRO L N   1 
ATOM   1961 C CA  . PRO B 2 51  ? 56.780 77.802  24.100  1.00 29.63  ? 44  PRO L CA  1 
ATOM   1962 C C   . PRO B 2 51  ? 57.920 76.838  24.300  1.00 29.02  ? 44  PRO L C   1 
ATOM   1963 O O   . PRO B 2 51  ? 57.724 75.630  24.268  1.00 28.53  ? 44  PRO L O   1 
ATOM   1964 C CB  . PRO B 2 51  ? 55.903 77.843  25.344  1.00 30.11  ? 44  PRO L CB  1 
ATOM   1965 C CG  . PRO B 2 51  ? 54.583 78.215  24.804  1.00 29.45  ? 44  PRO L CG  1 
ATOM   1966 C CD  . PRO B 2 51  ? 54.472 77.385  23.582  1.00 28.69  ? 44  PRO L CD  1 
ATOM   1967 N N   . LYS B 2 52  ? 59.111 77.385  24.488  1.00 32.29  ? 45  LYS L N   1 
ATOM   1968 C CA  . LYS B 2 52  ? 60.320 76.589  24.722  1.00 34.11  ? 45  LYS L CA  1 
ATOM   1969 C C   . LYS B 2 52  ? 60.935 76.998  26.050  1.00 31.74  ? 45  LYS L C   1 
ATOM   1970 O O   . LYS B 2 52  ? 61.043 78.173  26.359  1.00 31.07  ? 45  LYS L O   1 
ATOM   1971 C CB  . LYS B 2 52  ? 61.348 76.804  23.621  1.00 38.47  ? 45  LYS L CB  1 
ATOM   1972 C CG  . LYS B 2 52  ? 60.754 77.037  22.247  1.00 44.10  ? 45  LYS L CG  1 
ATOM   1973 C CD  . LYS B 2 52  ? 60.434 75.693  21.634  1.00 50.29  ? 45  LYS L CD  1 
ATOM   1974 C CE  . LYS B 2 52  ? 59.707 75.816  20.307  1.00 53.67  ? 45  LYS L CE  1 
ATOM   1975 N NZ  . LYS B 2 52  ? 59.060 74.498  20.020  1.00 56.02  ? 45  LYS L NZ  1 
ATOM   1976 N N   . LEU B 2 53  ? 61.351 76.017  26.817  1.00 29.37  ? 46  LEU L N   1 
ATOM   1977 C CA  . LEU B 2 53  ? 61.873 76.265  28.132  1.00 29.60  ? 46  LEU L CA  1 
ATOM   1978 C C   . LEU B 2 53  ? 63.252 76.908  28.046  1.00 32.34  ? 46  LEU L C   1 
ATOM   1979 O O   . LEU B 2 53  ? 64.094 76.462  27.274  1.00 35.59  ? 46  LEU L O   1 
ATOM   1980 C CB  . LEU B 2 53  ? 61.978 74.941  28.870  1.00 27.08  ? 46  LEU L CB  1 
ATOM   1981 C CG  . LEU B 2 53  ? 62.447 74.930  30.340  1.00 26.73  ? 46  LEU L CG  1 
ATOM   1982 C CD1 . LEU B 2 53  ? 61.587 75.737  31.285  1.00 25.75  ? 46  LEU L CD1 1 
ATOM   1983 C CD2 . LEU B 2 53  ? 62.531 73.498  30.829  1.00 26.28  ? 46  LEU L CD2 1 
ATOM   1984 N N   . LEU B 2 54  ? 63.477 77.953  28.838  1.00 32.05  ? 47  LEU L N   1 
ATOM   1985 C CA  . LEU B 2 54  ? 64.822 78.552  28.986  1.00 29.97  ? 47  LEU L CA  1 
ATOM   1986 C C   . LEU B 2 54  ? 65.477 78.168  30.278  1.00 27.83  ? 47  LEU L C   1 
ATOM   1987 O O   . LEU B 2 54  ? 66.566 77.599  30.281  1.00 29.24  ? 47  LEU L O   1 
ATOM   1988 C CB  . LEU B 2 54  ? 64.765 80.067  28.983  1.00 29.71  ? 47  LEU L CB  1 
ATOM   1989 C CG  . LEU B 2 54  ? 64.265 80.638  27.682  1.00 33.09  ? 47  LEU L CG  1 
ATOM   1990 C CD1 . LEU B 2 54  ? 63.993 82.098  27.921  1.00 33.86  ? 47  LEU L CD1 1 
ATOM   1991 C CD2 . LEU B 2 54  ? 65.246 80.462  26.541  1.00 33.60  ? 47  LEU L CD2 1 
ATOM   1992 N N   . ILE B 2 55  ? 64.791 78.518  31.363  1.00 25.97  ? 48  ILE L N   1 
ATOM   1993 C CA  . ILE B 2 55  ? 65.280 78.490  32.715  1.00 24.65  ? 48  ILE L CA  1 
ATOM   1994 C C   . ILE B 2 55  ? 64.235 77.752  33.516  1.00 25.01  ? 48  ILE L C   1 
ATOM   1995 O O   . ILE B 2 55  ? 63.048 78.048  33.407  1.00 24.99  ? 48  ILE L O   1 
ATOM   1996 C CB  . ILE B 2 55  ? 65.337 79.917  33.303  1.00 25.78  ? 48  ILE L CB  1 
ATOM   1997 C CG1 . ILE B 2 55  ? 66.336 80.795  32.527  1.00 25.62  ? 48  ILE L CG1 1 
ATOM   1998 C CG2 . ILE B 2 55  ? 65.599 79.910  34.831  1.00 24.74  ? 48  ILE L CG2 1 
ATOM   1999 C CD1 . ILE B 2 55  ? 67.795 80.457  32.755  1.00 26.66  ? 48  ILE L CD1 1 
ATOM   2000 N N   . TYR B 2 56  ? 64.669 76.864  34.396  1.00 25.31  ? 49  TYR L N   1 
ATOM   2001 C CA  . TYR B 2 56  ? 63.737 76.105  35.230  1.00 24.99  ? 49  TYR L CA  1 
ATOM   2002 C C   . TYR B 2 56  ? 64.166 76.096  36.695  1.00 23.51  ? 49  TYR L C   1 
ATOM   2003 O O   . TYR B 2 56  ? 65.279 76.406  37.018  1.00 23.23  ? 49  TYR L O   1 
ATOM   2004 C CB  . TYR B 2 56  ? 63.548 74.691  34.679  1.00 25.14  ? 49  TYR L CB  1 
ATOM   2005 C CG  . TYR B 2 56  ? 64.738 73.784  34.811  1.00 26.94  ? 49  TYR L CG  1 
ATOM   2006 C CD1 . TYR B 2 56  ? 64.924 73.026  35.954  1.00 27.32  ? 49  TYR L CD1 1 
ATOM   2007 C CD2 . TYR B 2 56  ? 65.677 73.681  33.794  1.00 28.61  ? 49  TYR L CD2 1 
ATOM   2008 C CE1 . TYR B 2 56  ? 66.000 72.198  36.090  1.00 26.35  ? 49  TYR L CE1 1 
ATOM   2009 C CE2 . TYR B 2 56  ? 66.765 72.853  33.922  1.00 28.57  ? 49  TYR L CE2 1 
ATOM   2010 C CZ  . TYR B 2 56  ? 66.909 72.109  35.067  1.00 28.72  ? 49  TYR L CZ  1 
ATOM   2011 O OH  . TYR B 2 56  ? 67.997 71.277  35.204  1.00 29.28  ? 49  TYR L OH  1 
ATOM   2012 N N   . THR B 2 57  ? 63.246 75.728  37.569  1.00 22.64  ? 50  THR L N   1 
ATOM   2013 C CA  . THR B 2 57  ? 63.424 75.762  39.005  1.00 21.71  ? 50  THR L CA  1 
ATOM   2014 C C   . THR B 2 57  ? 64.402 76.884  39.412  1.00 21.82  ? 50  THR L C   1 
ATOM   2015 O O   . THR B 2 57  ? 65.485 76.656  39.889  1.00 19.44  ? 50  THR L O   1 
ATOM   2016 C CB  . THR B 2 57  ? 63.842 74.357  39.439  1.00 22.74  ? 50  THR L CB  1 
ATOM   2017 O OG1 . THR B 2 57  ? 62.909 73.422  38.879  1.00 21.92  ? 50  THR L OG1 1 
ATOM   2018 C CG2 . THR B 2 57  ? 63.837 74.194  40.951  1.00 23.78  ? 50  THR L CG2 1 
ATOM   2019 N N   . LEU B 2 58  ? 63.987 78.087  39.061  1.00 22.28  ? 51  LEU L N   1 
ATOM   2020 C CA  . LEU B 2 58  ? 64.567 79.367  39.453  1.00 24.18  ? 51  LEU L CA  1 
ATOM   2021 C C   . LEU B 2 58  ? 65.674 79.853  38.590  1.00 25.73  ? 51  LEU L C   1 
ATOM   2022 O O   . LEU B 2 58  ? 65.568 80.941  38.027  1.00 28.99  ? 51  LEU L O   1 
ATOM   2023 C CB  . LEU B 2 58  ? 64.987 79.454  40.919  1.00 23.66  ? 51  LEU L CB  1 
ATOM   2024 C CG  . LEU B 2 58  ? 65.209 80.893  41.408  1.00 23.45  ? 51  LEU L CG  1 
ATOM   2025 C CD1 . LEU B 2 58  ? 63.925 81.669  41.399  1.00 27.65  ? 51  LEU L CD1 1 
ATOM   2026 C CD2 . LEU B 2 58  ? 65.694 80.857  42.828  1.00 24.99  ? 51  LEU L CD2 1 
ATOM   2027 N N   . SER B 2 59  ? 66.746 79.079  38.521  1.00 28.25  ? 52  SER L N   1 
ATOM   2028 C CA  . SER B 2 59  ? 67.948 79.507  37.840  1.00 29.04  ? 52  SER L CA  1 
ATOM   2029 C C   . SER B 2 59  ? 68.711 78.442  37.070  1.00 28.87  ? 52  SER L C   1 
ATOM   2030 O O   . SER B 2 59  ? 69.821 78.701  36.634  1.00 31.96  ? 52  SER L O   1 
ATOM   2031 C CB  . SER B 2 59  ? 68.852 80.174  38.869  1.00 28.95  ? 52  SER L CB  1 
ATOM   2032 O OG  . SER B 2 59  ? 69.243 79.236  39.822  1.00 30.77  ? 52  SER L OG  1 
ATOM   2033 N N   . ASN B 2 60  ? 68.132 77.271  36.846  1.00 29.12  ? 53  ASN L N   1 
ATOM   2034 C CA  . ASN B 2 60  ? 68.805 76.256  36.024  1.00 28.99  ? 53  ASN L CA  1 
ATOM   2035 C C   . ASN B 2 60  ? 68.575 76.463  34.535  1.00 29.64  ? 53  ASN L C   1 
ATOM   2036 O O   . ASN B 2 60  ? 67.450 76.645  34.115  1.00 28.27  ? 53  ASN L O   1 
ATOM   2037 C CB  . ASN B 2 60  ? 68.291 74.893  36.398  1.00 30.36  ? 53  ASN L CB  1 
ATOM   2038 C CG  . ASN B 2 60  ? 68.541 74.571  37.851  1.00 31.22  ? 53  ASN L CG  1 
ATOM   2039 O OD1 . ASN B 2 60  ? 69.604 74.077  38.190  1.00 32.29  ? 53  ASN L OD1 1 
ATOM   2040 N ND2 . ASN B 2 60  ? 67.569 74.837  38.707  1.00 31.63  ? 53  ASN L ND2 1 
ATOM   2041 N N   . ARG B 2 61  ? 69.619 76.374  33.723  1.00 30.95  ? 54  ARG L N   1 
ATOM   2042 C CA  . ARG B 2 61  ? 69.461 76.472  32.262  1.00 32.33  ? 54  ARG L CA  1 
ATOM   2043 C C   . ARG B 2 61  ? 68.976 75.170  31.651  1.00 30.69  ? 54  ARG L C   1 
ATOM   2044 O O   . ARG B 2 61  ? 69.600 74.134  31.803  1.00 30.31  ? 54  ARG L O   1 
ATOM   2045 C CB  . ARG B 2 61  ? 70.783 76.866  31.575  1.00 34.71  ? 54  ARG L CB  1 
ATOM   2046 C CG  . ARG B 2 61  ? 71.083 78.357  31.559  1.00 37.61  ? 54  ARG L CG  1 
ATOM   2047 C CD  . ARG B 2 61  ? 71.440 78.851  32.955  1.00 43.15  ? 54  ARG L CD  1 
ATOM   2048 N NE  . ARG B 2 61  ? 72.015 80.203  32.911  1.00 50.56  ? 54  ARG L NE  1 
ATOM   2049 C CZ  . ARG B 2 61  ? 72.888 80.718  33.785  1.00 51.11  ? 54  ARG L CZ  1 
ATOM   2050 N NH1 . ARG B 2 61  ? 73.336 80.017  34.829  1.00 56.69  ? 54  ARG L NH1 1 
ATOM   2051 N NH2 . ARG B 2 61  ? 73.323 81.959  33.615  1.00 49.91  ? 54  ARG L NH2 1 
ATOM   2052 N N   . PHE B 2 62  ? 67.893 75.228  30.894  1.00 30.13  ? 55  PHE L N   1 
ATOM   2053 C CA  . PHE B 2 62  ? 67.501 74.070  30.092  1.00 29.26  ? 55  PHE L CA  1 
ATOM   2054 C C   . PHE B 2 62  ? 68.682 73.721  29.160  1.00 28.28  ? 55  PHE L C   1 
ATOM   2055 O O   . PHE B 2 62  ? 69.421 74.601  28.747  1.00 28.22  ? 55  PHE L O   1 
ATOM   2056 C CB  . PHE B 2 62  ? 66.158 74.325  29.352  1.00 26.44  ? 55  PHE L CB  1 
ATOM   2057 C CG  . PHE B 2 62  ? 65.679 73.159  28.557  1.00 24.93  ? 55  PHE L CG  1 
ATOM   2058 C CD1 . PHE B 2 62  ? 65.477 71.935  29.163  1.00 25.43  ? 55  PHE L CD1 1 
ATOM   2059 C CD2 . PHE B 2 62  ? 65.447 73.274  27.190  1.00 26.15  ? 55  PHE L CD2 1 
ATOM   2060 C CE1 . PHE B 2 62  ? 65.046 70.827  28.435  1.00 25.06  ? 55  PHE L CE1 1 
ATOM   2061 C CE2 . PHE B 2 62  ? 65.031 72.183  26.451  1.00 27.91  ? 55  PHE L CE2 1 
ATOM   2062 C CZ  . PHE B 2 62  ? 64.829 70.948  27.082  1.00 27.53  ? 55  PHE L CZ  1 
ATOM   2063 N N   . SER B 2 63  ? 68.866 72.437  28.870  1.00 29.52  ? 56  SER L N   1 
ATOM   2064 C CA  . SER B 2 63  ? 70.030 71.956  28.096  1.00 31.21  ? 56  SER L CA  1 
ATOM   2065 C C   . SER B 2 63  ? 70.117 72.662  26.723  1.00 33.63  ? 56  SER L C   1 
ATOM   2066 O O   . SER B 2 63  ? 69.168 72.638  25.943  1.00 30.29  ? 56  SER L O   1 
ATOM   2067 C CB  . SER B 2 63  ? 69.996 70.418  27.944  1.00 32.60  ? 56  SER L CB  1 
ATOM   2068 O OG  . SER B 2 63  ? 70.323 69.967  26.636  1.00 32.37  ? 56  SER L OG  1 
ATOM   2069 N N   . GLY B 2 64  ? 71.241 73.337  26.483  1.00 33.89  ? 57  GLY L N   1 
ATOM   2070 C CA  . GLY B 2 64  ? 71.452 74.095  25.265  1.00 34.96  ? 57  GLY L CA  1 
ATOM   2071 C C   . GLY B 2 64  ? 71.112 75.563  25.361  1.00 33.93  ? 57  GLY L C   1 
ATOM   2072 O O   . GLY B 2 64  ? 71.417 76.330  24.444  1.00 39.58  ? 57  GLY L O   1 
ATOM   2073 N N   . VAL B 2 65  ? 70.458 75.963  26.440  1.00 32.55  ? 58  VAL L N   1 
ATOM   2074 C CA  . VAL B 2 65  ? 70.196 77.363  26.690  1.00 31.51  ? 58  VAL L CA  1 
ATOM   2075 C C   . VAL B 2 65  ? 71.514 77.990  27.100  1.00 32.50  ? 58  VAL L C   1 
ATOM   2076 O O   . VAL B 2 65  ? 72.136 77.527  28.045  1.00 32.87  ? 58  VAL L O   1 
ATOM   2077 C CB  . VAL B 2 65  ? 69.143 77.549  27.795  1.00 32.17  ? 58  VAL L CB  1 
ATOM   2078 C CG1 . VAL B 2 65  ? 69.014 79.014  28.224  1.00 31.43  ? 58  VAL L CG1 1 
ATOM   2079 C CG2 . VAL B 2 65  ? 67.806 76.975  27.322  1.00 33.43  ? 58  VAL L CG2 1 
ATOM   2080 N N   . PRO B 2 66  ? 71.948 79.051  26.398  1.00 34.75  ? 59  PRO L N   1 
ATOM   2081 C CA  . PRO B 2 66  ? 73.188 79.732  26.800  1.00 35.32  ? 59  PRO L CA  1 
ATOM   2082 C C   . PRO B 2 66  ? 73.084 80.448  28.157  1.00 35.63  ? 59  PRO L C   1 
ATOM   2083 O O   . PRO B 2 66  ? 72.002 80.761  28.594  1.00 37.57  ? 59  PRO L O   1 
ATOM   2084 C CB  . PRO B 2 66  ? 73.435 80.727  25.654  1.00 36.62  ? 59  PRO L CB  1 
ATOM   2085 C CG  . PRO B 2 66  ? 72.153 80.879  24.927  1.00 35.67  ? 59  PRO L CG  1 
ATOM   2086 C CD  . PRO B 2 66  ? 71.313 79.669  25.218  1.00 35.58  ? 59  PRO L CD  1 
ATOM   2087 N N   . ASP B 2 67  ? 74.211 80.720  28.798  1.00 38.41  ? 60  ASP L N   1 
ATOM   2088 C CA  . ASP B 2 67  ? 74.209 81.331  30.143  1.00 41.33  ? 60  ASP L CA  1 
ATOM   2089 C C   . ASP B 2 67  ? 73.959 82.816  30.145  1.00 38.91  ? 60  ASP L C   1 
ATOM   2090 O O   . ASP B 2 67  ? 73.767 83.397  31.207  1.00 37.09  ? 60  ASP L O   1 
ATOM   2091 C CB  . ASP B 2 67  ? 75.506 81.052  30.898  1.00 47.94  ? 60  ASP L CB  1 
ATOM   2092 C CG  . ASP B 2 67  ? 75.828 79.579  30.945  1.00 58.32  ? 60  ASP L CG  1 
ATOM   2093 O OD1 . ASP B 2 67  ? 75.382 78.899  31.909  1.00 60.03  ? 60  ASP L OD1 1 
ATOM   2094 O OD2 . ASP B 2 67  ? 76.480 79.101  29.973  1.00 68.64  ? 60  ASP L OD2 1 
ATOM   2095 N N   . ARG B 2 68  ? 73.952 83.431  28.965  1.00 36.61  ? 61  ARG L N   1 
ATOM   2096 C CA  . ARG B 2 68  ? 73.497 84.811  28.842  1.00 36.22  ? 61  ARG L CA  1 
ATOM   2097 C C   . ARG B 2 68  ? 72.023 84.998  29.243  1.00 36.70  ? 61  ARG L C   1 
ATOM   2098 O O   . ARG B 2 68  ? 71.576 86.130  29.507  1.00 35.50  ? 61  ARG L O   1 
ATOM   2099 C CB  . ARG B 2 68  ? 73.773 85.397  27.456  1.00 37.36  ? 61  ARG L CB  1 
ATOM   2100 C CG  . ARG B 2 68  ? 73.588 84.501  26.272  1.00 36.07  ? 61  ARG L CG  1 
ATOM   2101 C CD  . ARG B 2 68  ? 73.910 85.225  24.968  1.00 35.12  ? 61  ARG L CD  1 
ATOM   2102 N NE  . ARG B 2 68  ? 73.039 84.634  23.969  1.00 34.87  ? 61  ARG L NE  1 
ATOM   2103 C CZ  . ARG B 2 68  ? 71.812 85.062  23.669  1.00 32.80  ? 61  ARG L CZ  1 
ATOM   2104 N NH1 . ARG B 2 68  ? 71.322 86.170  24.212  1.00 34.23  ? 61  ARG L NH1 1 
ATOM   2105 N NH2 . ARG B 2 68  ? 71.077 84.381  22.791  1.00 31.94  ? 61  ARG L NH2 1 
ATOM   2106 N N   . PHE B 2 69  ? 71.286 83.893  29.284  1.00 34.04  ? 62  PHE L N   1 
ATOM   2107 C CA  . PHE B 2 69  ? 69.982 83.838  29.921  1.00 35.22  ? 62  PHE L CA  1 
ATOM   2108 C C   . PHE B 2 69  ? 70.176 83.427  31.369  1.00 34.76  ? 62  PHE L C   1 
ATOM   2109 O O   . PHE B 2 69  ? 70.664 82.332  31.626  1.00 38.92  ? 62  PHE L O   1 
ATOM   2110 C CB  . PHE B 2 69  ? 69.109 82.802  29.212  1.00 35.99  ? 62  PHE L CB  1 
ATOM   2111 C CG  . PHE B 2 69  ? 68.617 83.251  27.869  1.00 34.24  ? 62  PHE L CG  1 
ATOM   2112 C CD1 . PHE B 2 69  ? 67.507 84.073  27.773  1.00 34.25  ? 62  PHE L CD1 1 
ATOM   2113 C CD2 . PHE B 2 69  ? 69.252 82.851  26.709  1.00 34.56  ? 62  PHE L CD2 1 
ATOM   2114 C CE1 . PHE B 2 69  ? 67.038 84.482  26.536  1.00 32.54  ? 62  PHE L CE1 1 
ATOM   2115 C CE2 . PHE B 2 69  ? 68.793 83.271  25.470  1.00 35.05  ? 62  PHE L CE2 1 
ATOM   2116 C CZ  . PHE B 2 69  ? 67.691 84.097  25.388  1.00 33.20  ? 62  PHE L CZ  1 
ATOM   2117 N N   . SER B 2 70  ? 69.792 84.280  32.305  1.00 32.96  ? 63  SER L N   1 
ATOM   2118 C CA  . SER B 2 70  ? 70.020 84.007  33.708  1.00 35.37  ? 63  SER L CA  1 
ATOM   2119 C C   . SER B 2 70  ? 68.777 84.270  34.594  1.00 33.75  ? 63  SER L C   1 
ATOM   2120 O O   . SER B 2 70  ? 68.162 85.319  34.522  1.00 33.90  ? 63  SER L O   1 
ATOM   2121 C CB  . SER B 2 70  ? 71.217 84.835  34.156  1.00 36.77  ? 63  SER L CB  1 
ATOM   2122 O OG  . SER B 2 70  ? 71.199 85.025  35.562  1.00 44.67  ? 63  SER L OG  1 
ATOM   2123 N N   . GLY B 2 71  ? 68.425 83.315  35.435  1.00 34.80  ? 64  GLY L N   1 
ATOM   2124 C CA  . GLY B 2 71  ? 67.224 83.416  36.283  1.00 35.68  ? 64  GLY L CA  1 
ATOM   2125 C C   . GLY B 2 71  ? 67.617 83.615  37.732  1.00 35.63  ? 64  GLY L C   1 
ATOM   2126 O O   . GLY B 2 71  ? 68.536 82.964  38.203  1.00 34.97  ? 64  GLY L O   1 
ATOM   2127 N N   . SER B 2 72  ? 66.948 84.538  38.422  1.00 33.75  ? 65  SER L N   1 
ATOM   2128 C CA  . SER B 2 72  ? 67.198 84.768  39.826  1.00 33.98  ? 65  SER L CA  1 
ATOM   2129 C C   . SER B 2 72  ? 65.900 85.085  40.514  1.00 34.37  ? 65  SER L C   1 
ATOM   2130 O O   . SER B 2 72  ? 64.842 85.131  39.883  1.00 34.71  ? 65  SER L O   1 
ATOM   2131 C CB  . SER B 2 72  ? 68.251 85.884  40.051  1.00 34.88  ? 65  SER L CB  1 
ATOM   2132 O OG  . SER B 2 72  ? 67.763 87.180  39.747  1.00 35.80  ? 65  SER L OG  1 
ATOM   2133 N N   . GLY B 2 73  ? 66.010 85.278  41.822  1.00 36.21  ? 66  GLY L N   1 
ATOM   2134 C CA  . GLY B 2 73  ? 64.927 85.753  42.667  1.00 40.21  ? 66  GLY L CA  1 
ATOM   2135 C C   . GLY B 2 73  ? 64.821 84.931  43.914  1.00 42.44  ? 66  GLY L C   1 
ATOM   2136 O O   . GLY B 2 73  ? 65.670 84.111  44.212  1.00 45.40  ? 66  GLY L O   1 
ATOM   2137 N N   . SER B 2 74  ? 63.770 85.197  44.657  1.00 50.43  ? 67  SER L N   1 
ATOM   2138 C CA  . SER B 2 74  ? 63.299 84.330  45.742  1.00 50.75  ? 67  SER L CA  1 
ATOM   2139 C C   . SER B 2 74  ? 62.088 85.010  46.383  1.00 56.25  ? 67  SER L C   1 
ATOM   2140 O O   . SER B 2 74  ? 61.823 86.215  46.170  1.00 57.29  ? 67  SER L O   1 
ATOM   2141 C CB  . SER B 2 74  ? 64.352 84.144  46.822  1.00 48.32  ? 67  SER L CB  1 
ATOM   2142 O OG  . SER B 2 74  ? 64.461 85.359  47.530  1.00 44.73  ? 67  SER L OG  1 
ATOM   2143 N N   . GLY B 2 75  ? 61.399 84.238  47.215  1.00 60.72  ? 68  GLY L N   1 
ATOM   2144 C CA  . GLY B 2 75  ? 60.195 84.695  47.880  1.00 55.85  ? 68  GLY L CA  1 
ATOM   2145 C C   . GLY B 2 75  ? 59.123 84.833  46.821  1.00 52.15  ? 68  GLY L C   1 
ATOM   2146 O O   . GLY B 2 75  ? 58.616 83.816  46.306  1.00 46.44  ? 68  GLY L O   1 
ATOM   2147 N N   . THR B 2 76  ? 58.824 86.098  46.495  1.00 47.63  ? 69  THR L N   1 
ATOM   2148 C CA  . THR B 2 76  ? 57.830 86.475  45.483  1.00 45.17  ? 69  THR L CA  1 
ATOM   2149 C C   . THR B 2 76  ? 58.362 87.314  44.309  1.00 43.82  ? 69  THR L C   1 
ATOM   2150 O O   . THR B 2 76  ? 57.613 87.557  43.354  1.00 41.27  ? 69  THR L O   1 
ATOM   2151 C CB  . THR B 2 76  ? 56.695 87.297  46.113  1.00 42.22  ? 69  THR L CB  1 
ATOM   2152 O OG1 . THR B 2 76  ? 57.266 88.303  46.955  1.00 40.82  ? 69  THR L OG1 1 
ATOM   2153 C CG2 . THR B 2 76  ? 55.767 86.418  46.901  1.00 40.11  ? 69  THR L CG2 1 
ATOM   2154 N N   . ASP B 2 77  ? 59.609 87.781  44.367  1.00 40.99  ? 70  ASP L N   1 
ATOM   2155 C CA  . ASP B 2 77  ? 60.175 88.525  43.221  1.00 46.01  ? 70  ASP L CA  1 
ATOM   2156 C C   . ASP B 2 77  ? 61.201 87.727  42.413  1.00 42.31  ? 70  ASP L C   1 
ATOM   2157 O O   . ASP B 2 77  ? 62.138 87.145  42.969  1.00 48.57  ? 70  ASP L O   1 
ATOM   2158 C CB  . ASP B 2 77  ? 60.679 89.907  43.636  1.00 46.68  ? 70  ASP L CB  1 
ATOM   2159 C CG  . ASP B 2 77  ? 59.531 90.904  43.724  1.00 51.62  ? 70  ASP L CG  1 
ATOM   2160 O OD1 . ASP B 2 77  ? 59.167 91.479  42.672  1.00 55.52  ? 70  ASP L OD1 1 
ATOM   2161 O OD2 . ASP B 2 77  ? 58.943 91.047  44.823  1.00 52.47  ? 70  ASP L OD2 1 
ATOM   2162 N N   . PHE B 2 78  ? 60.988 87.696  41.101  1.00 36.16  ? 71  PHE L N   1 
ATOM   2163 C CA  . PHE B 2 78  ? 61.774 86.864  40.190  1.00 35.47  ? 71  PHE L CA  1 
ATOM   2164 C C   . PHE B 2 78  ? 62.172 87.685  38.963  1.00 34.99  ? 71  PHE L C   1 
ATOM   2165 O O   . PHE B 2 78  ? 61.392 88.526  38.476  1.00 30.44  ? 71  PHE L O   1 
ATOM   2166 C CB  . PHE B 2 78  ? 61.019 85.555  39.849  1.00 32.90  ? 71  PHE L CB  1 
ATOM   2167 C CG  . PHE B 2 78  ? 60.596 84.766  41.086  1.00 32.72  ? 71  PHE L CG  1 
ATOM   2168 C CD1 . PHE B 2 78  ? 61.537 84.038  41.832  1.00 33.79  ? 71  PHE L CD1 1 
ATOM   2169 C CD2 . PHE B 2 78  ? 59.285 84.789  41.542  1.00 32.36  ? 71  PHE L CD2 1 
ATOM   2170 C CE1 . PHE B 2 78  ? 61.171 83.334  42.983  1.00 33.19  ? 71  PHE L CE1 1 
ATOM   2171 C CE2 . PHE B 2 78  ? 58.914 84.086  42.690  1.00 33.31  ? 71  PHE L CE2 1 
ATOM   2172 C CZ  . PHE B 2 78  ? 59.860 83.360  43.413  1.00 31.24  ? 71  PHE L CZ  1 
ATOM   2173 N N   . THR B 2 79  ? 63.407 87.455  38.509  1.00 33.42  ? 72  THR L N   1 
ATOM   2174 C CA  . THR B 2 79  ? 63.930 88.132  37.332  1.00 35.53  ? 72  THR L CA  1 
ATOM   2175 C C   . THR B 2 79  ? 64.513 87.174  36.324  1.00 34.32  ? 72  THR L C   1 
ATOM   2176 O O   . THR B 2 79  ? 65.177 86.207  36.684  1.00 36.45  ? 72  THR L O   1 
ATOM   2177 C CB  . THR B 2 79  ? 65.032 89.131  37.692  1.00 34.86  ? 72  THR L CB  1 
ATOM   2178 O OG1 . THR B 2 79  ? 64.452 90.130  38.510  1.00 36.56  ? 72  THR L OG1 1 
ATOM   2179 C CG2 . THR B 2 79  ? 65.600 89.815  36.464  1.00 34.39  ? 72  THR L CG2 1 
ATOM   2180 N N   . LEU B 2 80  ? 64.250 87.486  35.056  1.00 33.72  ? 73  LEU L N   1 
ATOM   2181 C CA  . LEU B 2 80  ? 64.956 86.919  33.931  1.00 31.91  ? 73  LEU L CA  1 
ATOM   2182 C C   . LEU B 2 80  ? 65.833 88.009  33.337  1.00 31.05  ? 73  LEU L C   1 
ATOM   2183 O O   . LEU B 2 80  ? 65.330 89.003  32.812  1.00 26.70  ? 73  LEU L O   1 
ATOM   2184 C CB  . LEU B 2 80  ? 63.986 86.442  32.865  1.00 31.60  ? 73  LEU L CB  1 
ATOM   2185 C CG  . LEU B 2 80  ? 64.610 85.728  31.665  1.00 32.86  ? 73  LEU L CG  1 
ATOM   2186 C CD1 . LEU B 2 80  ? 65.313 84.425  32.067  1.00 34.39  ? 73  LEU L CD1 1 
ATOM   2187 C CD2 . LEU B 2 80  ? 63.570 85.485  30.583  1.00 32.64  ? 73  LEU L CD2 1 
ATOM   2188 N N   . LYS B 2 81  ? 67.141 87.800  33.416  1.00 31.61  ? 74  LYS L N   1 
ATOM   2189 C CA  . LYS B 2 81  ? 68.099 88.636  32.704  1.00 34.65  ? 74  LYS L CA  1 
ATOM   2190 C C   . LYS B 2 81  ? 68.602 87.943  31.444  1.00 33.16  ? 74  LYS L C   1 
ATOM   2191 O O   . LYS B 2 81  ? 69.052 86.810  31.502  1.00 32.63  ? 74  LYS L O   1 
ATOM   2192 C CB  . LYS B 2 81  ? 69.270 88.987  33.593  1.00 34.40  ? 74  LYS L CB  1 
ATOM   2193 C CG  . LYS B 2 81  ? 70.232 89.911  32.886  1.00 37.95  ? 74  LYS L CG  1 
ATOM   2194 C CD  . LYS B 2 81  ? 71.169 90.601  33.851  1.00 40.69  ? 74  LYS L CD  1 
ATOM   2195 C CE  . LYS B 2 81  ? 72.535 89.961  33.882  1.00 40.57  ? 74  LYS L CE  1 
ATOM   2196 N NZ  . LYS B 2 81  ? 73.200 90.423  35.131  1.00 43.85  ? 74  LYS L NZ  1 
ATOM   2197 N N   . ILE B 2 82  ? 68.513 88.646  30.316  1.00 34.74  ? 75  ILE L N   1 
ATOM   2198 C CA  . ILE B 2 82  ? 69.086 88.198  29.038  1.00 36.72  ? 75  ILE L CA  1 
ATOM   2199 C C   . ILE B 2 82  ? 70.313 89.065  28.747  1.00 40.35  ? 75  ILE L C   1 
ATOM   2200 O O   . ILE B 2 82  ? 70.205 90.284  28.673  1.00 43.62  ? 75  ILE L O   1 
ATOM   2201 C CB  . ILE B 2 82  ? 68.084 88.303  27.883  1.00 32.97  ? 75  ILE L CB  1 
ATOM   2202 C CG1 . ILE B 2 82  ? 66.831 87.483  28.189  1.00 32.41  ? 75  ILE L CG1 1 
ATOM   2203 C CG2 . ILE B 2 82  ? 68.709 87.818  26.588  1.00 33.11  ? 75  ILE L CG2 1 
ATOM   2204 C CD1 . ILE B 2 82  ? 65.572 88.300  28.349  1.00 32.58  ? 75  ILE L CD1 1 
ATOM   2205 N N   . SER B 2 83  ? 71.469 88.450  28.554  1.00 42.83  ? 76  SER L N   1 
ATOM   2206 C CA  . SER B 2 83  ? 72.706 89.224  28.618  1.00 53.00  ? 76  SER L CA  1 
ATOM   2207 C C   . SER B 2 83  ? 73.219 89.838  27.312  1.00 55.54  ? 76  SER L C   1 
ATOM   2208 O O   . SER B 2 83  ? 73.672 90.980  27.331  1.00 63.60  ? 76  SER L O   1 
ATOM   2209 C CB  . SER B 2 83  ? 73.815 88.433  29.278  1.00 53.73  ? 76  SER L CB  1 
ATOM   2210 O OG  . SER B 2 83  ? 74.857 89.319  29.615  1.00 59.65  ? 76  SER L OG  1 
ATOM   2211 N N   . ARG B 2 84  ? 73.186 89.110  26.201  1.00 59.71  ? 77  ARG L N   1 
ATOM   2212 C CA  . ARG B 2 84  ? 73.674 89.673  24.918  1.00 62.49  ? 77  ARG L CA  1 
ATOM   2213 C C   . ARG B 2 84  ? 72.607 89.532  23.843  1.00 58.08  ? 77  ARG L C   1 
ATOM   2214 O O   . ARG B 2 84  ? 72.754 88.758  22.893  1.00 58.58  ? 77  ARG L O   1 
ATOM   2215 C CB  . ARG B 2 84  ? 74.997 89.024  24.499  1.00 67.02  ? 77  ARG L CB  1 
ATOM   2216 C CG  . ARG B 2 84  ? 76.211 89.681  25.121  1.00 72.18  ? 77  ARG L CG  1 
ATOM   2217 C CD  . ARG B 2 84  ? 77.450 88.950  24.676  1.00 78.50  ? 77  ARG L CD  1 
ATOM   2218 N NE  . ARG B 2 84  ? 78.669 89.572  25.177  1.00 87.58  ? 77  ARG L NE  1 
ATOM   2219 C CZ  . ARG B 2 84  ? 79.255 90.658  24.665  1.00 93.30  ? 77  ARG L CZ  1 
ATOM   2220 N NH1 . ARG B 2 84  ? 78.733 91.313  23.625  1.00 98.65  ? 77  ARG L NH1 1 
ATOM   2221 N NH2 . ARG B 2 84  ? 80.383 91.097  25.215  1.00 95.11  ? 77  ARG L NH2 1 
ATOM   2222 N N   . VAL B 2 85  ? 71.537 90.304  24.003  1.00 48.27  ? 78  VAL L N   1 
ATOM   2223 C CA  . VAL B 2 85  ? 70.318 90.074  23.235  1.00 46.48  ? 78  VAL L CA  1 
ATOM   2224 C C   . VAL B 2 85  ? 70.611 89.905  21.738  1.00 48.04  ? 78  VAL L C   1 
ATOM   2225 O O   . VAL B 2 85  ? 71.190 90.792  21.091  1.00 50.69  ? 78  VAL L O   1 
ATOM   2226 C CB  . VAL B 2 85  ? 69.247 91.168  23.469  1.00 45.66  ? 78  VAL L CB  1 
ATOM   2227 C CG1 . VAL B 2 85  ? 68.037 90.979  22.552  1.00 43.47  ? 78  VAL L CG1 1 
ATOM   2228 C CG2 . VAL B 2 85  ? 68.782 91.159  24.921  1.00 46.09  ? 78  VAL L CG2 1 
ATOM   2229 N N   . GLU B 2 86  ? 70.221 88.745  21.226  1.00 44.84  ? 79  GLU L N   1 
ATOM   2230 C CA  . GLU B 2 86  ? 70.264 88.441  19.804  1.00 47.97  ? 79  GLU L CA  1 
ATOM   2231 C C   . GLU B 2 86  ? 68.862 88.470  19.192  1.00 46.21  ? 79  GLU L C   1 
ATOM   2232 O O   . GLU B 2 86  ? 67.852 88.487  19.896  1.00 50.68  ? 79  GLU L O   1 
ATOM   2233 C CB  . GLU B 2 86  ? 70.926 87.079  19.577  1.00 48.31  ? 79  GLU L CB  1 
ATOM   2234 C CG  . GLU B 2 86  ? 72.295 86.935  20.247  1.00 48.44  ? 79  GLU L CG  1 
ATOM   2235 C CD  . GLU B 2 86  ? 72.869 85.547  20.112  1.00 49.71  ? 79  GLU L CD  1 
ATOM   2236 O OE1 . GLU B 2 86  ? 72.371 84.788  19.250  1.00 49.14  ? 79  GLU L OE1 1 
ATOM   2237 O OE2 . GLU B 2 86  ? 73.807 85.212  20.873  1.00 54.51  ? 79  GLU L OE2 1 
ATOM   2238 N N   . ALA B 2 87  ? 68.818 88.480  17.871  1.00 42.66  ? 80  ALA L N   1 
ATOM   2239 C CA  . ALA B 2 87  ? 67.570 88.595  17.129  1.00 41.52  ? 80  ALA L CA  1 
ATOM   2240 C C   . ALA B 2 87  ? 66.655 87.425  17.409  1.00 41.27  ? 80  ALA L C   1 
ATOM   2241 O O   . ALA B 2 87  ? 65.464 87.600  17.651  1.00 45.50  ? 80  ALA L O   1 
ATOM   2242 C CB  . ALA B 2 87  ? 67.864 88.660  15.643  1.00 42.07  ? 80  ALA L CB  1 
ATOM   2243 N N   . ALA B 2 88  ? 67.220 86.226  17.368  1.00 39.63  ? 81  ALA L N   1 
ATOM   2244 C CA  . ALA B 2 88  ? 66.480 85.016  17.673  1.00 42.07  ? 81  ALA L CA  1 
ATOM   2245 C C   . ALA B 2 88  ? 65.989 84.932  19.130  1.00 43.60  ? 81  ALA L C   1 
ATOM   2246 O O   . ALA B 2 88  ? 65.310 83.973  19.468  1.00 50.74  ? 81  ALA L O   1 
ATOM   2247 C CB  . ALA B 2 88  ? 67.330 83.797  17.352  1.00 43.73  ? 81  ALA L CB  1 
ATOM   2248 N N   . ASP B 2 89  ? 66.361 85.881  19.989  1.00 38.51  ? 82  ASP L N   1 
ATOM   2249 C CA  . ASP B 2 89  ? 65.760 86.021  21.322  1.00 38.95  ? 82  ASP L CA  1 
ATOM   2250 C C   . ASP B 2 89  ? 64.415 86.757  21.358  1.00 37.40  ? 82  ASP L C   1 
ATOM   2251 O O   . ASP B 2 89  ? 63.750 86.742  22.391  1.00 36.66  ? 82  ASP L O   1 
ATOM   2252 C CB  . ASP B 2 89  ? 66.690 86.772  22.274  1.00 40.16  ? 82  ASP L CB  1 
ATOM   2253 C CG  . ASP B 2 89  ? 68.052 86.137  22.400  1.00 43.78  ? 82  ASP L CG  1 
ATOM   2254 O OD1 . ASP B 2 89  ? 68.203 84.896  22.224  1.00 42.13  ? 82  ASP L OD1 1 
ATOM   2255 O OD2 . ASP B 2 89  ? 68.993 86.909  22.701  1.00 47.26  ? 82  ASP L OD2 1 
ATOM   2256 N N   . LEU B 2 90  ? 64.040 87.423  20.265  1.00 35.26  ? 83  LEU L N   1 
ATOM   2257 C CA  . LEU B 2 90  ? 62.817 88.214  20.221  1.00 34.18  ? 83  LEU L CA  1 
ATOM   2258 C C   . LEU B 2 90  ? 61.600 87.326  20.210  1.00 30.35  ? 83  LEU L C   1 
ATOM   2259 O O   . LEU B 2 90  ? 61.639 86.251  19.626  1.00 31.25  ? 83  LEU L O   1 
ATOM   2260 C CB  . LEU B 2 90  ? 62.792 89.114  18.999  1.00 36.67  ? 83  LEU L CB  1 
ATOM   2261 C CG  . LEU B 2 90  ? 63.929 90.135  18.920  1.00 39.04  ? 83  LEU L CG  1 
ATOM   2262 C CD1 . LEU B 2 90  ? 63.768 90.875  17.595  1.00 39.76  ? 83  LEU L CD1 1 
ATOM   2263 C CD2 . LEU B 2 90  ? 64.019 91.089  20.106  1.00 37.52  ? 83  LEU L CD2 1 
ATOM   2264 N N   . GLY B 2 91  ? 60.546 87.803  20.873  1.00 27.94  ? 84  GLY L N   1 
ATOM   2265 C CA  . GLY B 2 91  ? 59.252 87.115  20.995  1.00 28.31  ? 84  GLY L CA  1 
ATOM   2266 C C   . GLY B 2 91  ? 58.710 87.324  22.396  1.00 27.48  ? 84  GLY L C   1 
ATOM   2267 O O   . GLY B 2 91  ? 59.046 88.307  23.045  1.00 24.12  ? 84  GLY L O   1 
ATOM   2268 N N   . ILE B 2 92  ? 57.884 86.399  22.878  1.00 28.54  ? 85  ILE L N   1 
ATOM   2269 C CA  . ILE B 2 92  ? 57.205 86.610  24.167  1.00 30.18  ? 85  ILE L CA  1 
ATOM   2270 C C   . ILE B 2 92  ? 57.739 85.677  25.244  1.00 28.67  ? 85  ILE L C   1 
ATOM   2271 O O   . ILE B 2 92  ? 57.817 84.454  25.043  1.00 29.87  ? 85  ILE L O   1 
ATOM   2272 C CB  . ILE B 2 92  ? 55.669 86.389  24.108  1.00 30.43  ? 85  ILE L CB  1 
ATOM   2273 C CG1 . ILE B 2 92  ? 55.072 86.936  22.803  1.00 30.67  ? 85  ILE L CG1 1 
ATOM   2274 C CG2 . ILE B 2 92  ? 55.005 86.912  25.404  1.00 28.97  ? 85  ILE L CG2 1 
ATOM   2275 C CD1 . ILE B 2 92  ? 54.708 88.393  22.807  1.00 31.94  ? 85  ILE L CD1 1 
ATOM   2276 N N   . TYR B 2 93  ? 58.043 86.259  26.390  1.00 27.77  ? 86  TYR L N   1 
ATOM   2277 C CA  . TYR B 2 93  ? 58.598 85.523  27.508  1.00 29.92  ? 86  TYR L CA  1 
ATOM   2278 C C   . TYR B 2 93  ? 57.531 85.380  28.545  1.00 28.52  ? 86  TYR L C   1 
ATOM   2279 O O   . TYR B 2 93  ? 56.955 86.369  28.981  1.00 29.37  ? 86  TYR L O   1 
ATOM   2280 C CB  . TYR B 2 93  ? 59.801 86.245  28.122  1.00 29.39  ? 86  TYR L CB  1 
ATOM   2281 C CG  . TYR B 2 93  ? 61.006 86.189  27.250  1.00 28.55  ? 86  TYR L CG  1 
ATOM   2282 C CD1 . TYR B 2 93  ? 61.100 87.006  26.140  1.00 29.25  ? 86  TYR L CD1 1 
ATOM   2283 C CD2 . TYR B 2 93  ? 62.062 85.308  27.517  1.00 30.01  ? 86  TYR L CD2 1 
ATOM   2284 C CE1 . TYR B 2 93  ? 62.210 86.967  25.302  1.00 29.37  ? 86  TYR L CE1 1 
ATOM   2285 C CE2 . TYR B 2 93  ? 63.180 85.254  26.682  1.00 30.77  ? 86  TYR L CE2 1 
ATOM   2286 C CZ  . TYR B 2 93  ? 63.260 86.106  25.575  1.00 31.62  ? 86  TYR L CZ  1 
ATOM   2287 O OH  . TYR B 2 93  ? 64.346 86.076  24.701  1.00 30.83  ? 86  TYR L OH  1 
ATOM   2288 N N   . PHE B 2 94  ? 57.272 84.144  28.926  1.00 28.11  ? 87  PHE L N   1 
ATOM   2289 C CA  . PHE B 2 94  ? 56.331 83.835  30.002  1.00 30.30  ? 87  PHE L CA  1 
ATOM   2290 C C   . PHE B 2 94  ? 57.064 83.299  31.238  1.00 28.61  ? 87  PHE L C   1 
ATOM   2291 O O   . PHE B 2 94  ? 58.015 82.557  31.099  1.00 28.45  ? 87  PHE L O   1 
ATOM   2292 C CB  . PHE B 2 94  ? 55.351 82.767  29.520  1.00 30.82  ? 87  PHE L CB  1 
ATOM   2293 C CG  . PHE B 2 94  ? 54.425 83.213  28.417  1.00 30.17  ? 87  PHE L CG  1 
ATOM   2294 C CD1 . PHE B 2 94  ? 53.202 83.785  28.714  1.00 30.98  ? 87  PHE L CD1 1 
ATOM   2295 C CD2 . PHE B 2 94  ? 54.734 82.971  27.091  1.00 32.38  ? 87  PHE L CD2 1 
ATOM   2296 C CE1 . PHE B 2 94  ? 52.314 84.155  27.706  1.00 32.94  ? 87  PHE L CE1 1 
ATOM   2297 C CE2 . PHE B 2 94  ? 53.855 83.319  26.075  1.00 32.42  ? 87  PHE L CE2 1 
ATOM   2298 C CZ  . PHE B 2 94  ? 52.637 83.923  26.381  1.00 31.14  ? 87  PHE L CZ  1 
ATOM   2299 N N   . CYS B 2 95  ? 56.627 83.668  32.441  1.00 29.10  ? 88  CYS L N   1 
ATOM   2300 C CA  . CYS B 2 95  ? 57.033 82.913  33.637  1.00 26.87  ? 88  CYS L CA  1 
ATOM   2301 C C   . CYS B 2 95  ? 55.918 81.957  33.965  1.00 27.00  ? 88  CYS L C   1 
ATOM   2302 O O   . CYS B 2 95  ? 54.795 82.084  33.447  1.00 27.99  ? 88  CYS L O   1 
ATOM   2303 C CB  . CYS B 2 95  ? 57.385 83.787  34.840  1.00 27.44  ? 88  CYS L CB  1 
ATOM   2304 S SG  . CYS B 2 95  ? 56.139 85.000  35.241  1.00 29.45  ? 88  CYS L SG  1 
ATOM   2305 N N   . SER B 2 96  ? 56.262 80.972  34.783  1.00 24.71  ? 89  SER L N   1 
ATOM   2306 C CA  . SER B 2 96  ? 55.360 79.918  35.168  1.00 23.91  ? 89  SER L CA  1 
ATOM   2307 C C   . SER B 2 96  ? 55.796 79.357  36.517  1.00 23.40  ? 89  SER L C   1 
ATOM   2308 O O   . SER B 2 96  ? 57.018 79.182  36.762  1.00 20.82  ? 89  SER L O   1 
ATOM   2309 C CB  . SER B 2 96  ? 55.381 78.815  34.127  1.00 24.34  ? 89  SER L CB  1 
ATOM   2310 O OG  . SER B 2 96  ? 54.548 77.742  34.509  1.00 24.98  ? 89  SER L OG  1 
ATOM   2311 N N   . GLN B 2 97  ? 54.818 79.085  37.378  1.00 22.60  ? 90  GLN L N   1 
ATOM   2312 C CA  . GLN B 2 97  ? 55.092 78.371  38.630  1.00 25.16  ? 90  GLN L CA  1 
ATOM   2313 C C   . GLN B 2 97  ? 54.471 76.969  38.627  1.00 25.70  ? 90  GLN L C   1 
ATOM   2314 O O   . GLN B 2 97  ? 53.312 76.775  38.228  1.00 25.65  ? 90  GLN L O   1 
ATOM   2315 C CB  . GLN B 2 97  ? 54.733 79.176  39.884  1.00 23.77  ? 90  GLN L CB  1 
ATOM   2316 C CG  . GLN B 2 97  ? 53.270 79.348  40.152  1.00 24.40  ? 90  GLN L CG  1 
ATOM   2317 C CD  . GLN B 2 97  ? 52.597 78.142  40.770  1.00 22.92  ? 90  GLN L CD  1 
ATOM   2318 O OE1 . GLN B 2 97  ? 53.233 77.366  41.435  1.00 23.49  ? 90  GLN L OE1 1 
ATOM   2319 N NE2 . GLN B 2 97  ? 51.295 77.989  40.539  1.00 22.44  ? 90  GLN L NE2 1 
ATOM   2320 N N   . THR B 2 98  ? 55.260 75.996  39.077  1.00 25.53  ? 91  THR L N   1 
ATOM   2321 C CA  . THR B 2 98  ? 54.758 74.660  39.321  1.00 25.26  ? 91  THR L CA  1 
ATOM   2322 C C   . THR B 2 98  ? 54.902 74.243  40.774  1.00 26.23  ? 91  THR L C   1 
ATOM   2323 O O   . THR B 2 98  ? 54.812 73.068  41.076  1.00 27.14  ? 91  THR L O   1 
ATOM   2324 C CB  . THR B 2 98  ? 55.403 73.630  38.396  1.00 24.53  ? 91  THR L CB  1 
ATOM   2325 O OG1 . THR B 2 98  ? 56.815 73.544  38.656  1.00 30.31  ? 91  THR L OG1 1 
ATOM   2326 C CG2 . THR B 2 98  ? 55.170 73.984  36.944  1.00 23.61  ? 91  THR L CG2 1 
ATOM   2327 N N   . THR B 2 99  ? 55.096 75.194  41.683  1.00 27.69  ? 92  THR L N   1 
ATOM   2328 C CA  . THR B 2 99  ? 55.259 74.844  43.107  1.00 27.41  ? 92  THR L CA  1 
ATOM   2329 C C   . THR B 2 99  ? 53.958 74.341  43.653  1.00 29.55  ? 92  THR L C   1 
ATOM   2330 O O   . THR B 2 99  ? 53.966 73.408  44.429  1.00 30.43  ? 92  THR L O   1 
ATOM   2331 C CB  . THR B 2 99  ? 55.657 76.041  43.993  1.00 26.17  ? 92  THR L CB  1 
ATOM   2332 O OG1 . THR B 2 99  ? 56.949 76.501  43.641  1.00 23.19  ? 92  THR L OG1 1 
ATOM   2333 C CG2 . THR B 2 99  ? 55.714 75.659  45.478  1.00 26.61  ? 92  THR L CG2 1 
ATOM   2334 N N   . HIS B 2 100 ? 52.862 75.010  43.276  1.00 31.85  ? 93  HIS L N   1 
ATOM   2335 C CA  . HIS B 2 100 ? 51.522 74.741  43.785  1.00 34.98  ? 93  HIS L CA  1 
ATOM   2336 C C   . HIS B 2 100 ? 50.614 74.379  42.659  1.00 33.05  ? 93  HIS L C   1 
ATOM   2337 O O   . HIS B 2 100 ? 50.648 75.028  41.646  1.00 36.02  ? 93  HIS L O   1 
ATOM   2338 C CB  . HIS B 2 100 ? 50.929 75.996  44.414  1.00 39.11  ? 93  HIS L CB  1 
ATOM   2339 C CG  . HIS B 2 100 ? 51.643 76.449  45.638  1.00 42.43  ? 93  HIS L CG  1 
ATOM   2340 N ND1 . HIS B 2 100 ? 51.379 75.924  46.880  1.00 44.06  ? 93  HIS L ND1 1 
ATOM   2341 C CD2 . HIS B 2 100 ? 52.613 77.378  45.813  1.00 46.54  ? 93  HIS L CD2 1 
ATOM   2342 C CE1 . HIS B 2 100 ? 52.161 76.509  47.770  1.00 47.30  ? 93  HIS L CE1 1 
ATOM   2343 N NE2 . HIS B 2 100 ? 52.916 77.397  47.150  1.00 44.96  ? 93  HIS L NE2 1 
ATOM   2344 N N   . VAL B 2 101 ? 49.774 73.379  42.880  1.00 34.60  ? 94  VAL L N   1 
ATOM   2345 C CA  . VAL B 2 101 ? 48.720 72.985  41.973  1.00 35.44  ? 94  VAL L CA  1 
ATOM   2346 C C   . VAL B 2 101 ? 47.512 73.890  42.198  1.00 32.61  ? 94  VAL L C   1 
ATOM   2347 O O   . VAL B 2 101 ? 47.126 74.076  43.333  1.00 34.65  ? 94  VAL L O   1 
ATOM   2348 C CB  . VAL B 2 101 ? 48.330 71.513  42.230  1.00 37.16  ? 94  VAL L CB  1 
ATOM   2349 C CG1 . VAL B 2 101 ? 47.136 71.069  41.382  1.00 38.11  ? 94  VAL L CG1 1 
ATOM   2350 C CG2 . VAL B 2 101 ? 49.524 70.612  41.957  1.00 37.02  ? 94  VAL L CG2 1 
ATOM   2351 N N   . PRO B 2 102 ? 46.902 74.443  41.151  1.00 33.09  ? 95  PRO L N   1 
ATOM   2352 C CA  . PRO B 2 102 ? 47.309 74.250  39.769  1.00 31.12  ? 95  PRO L CA  1 
ATOM   2353 C C   . PRO B 2 102 ? 48.476 75.164  39.366  1.00 30.76  ? 95  PRO L C   1 
ATOM   2354 O O   . PRO B 2 102 ? 48.586 76.311  39.842  1.00 27.90  ? 95  PRO L O   1 
ATOM   2355 C CB  . PRO B 2 102 ? 46.055 74.609  38.997  1.00 31.23  ? 95  PRO L CB  1 
ATOM   2356 C CG  . PRO B 2 102 ? 45.484 75.713  39.788  1.00 32.09  ? 95  PRO L CG  1 
ATOM   2357 C CD  . PRO B 2 102 ? 45.798 75.411  41.239  1.00 32.17  ? 95  PRO L CD  1 
ATOM   2358 N N   . TYR B 2 103 ? 49.320 74.631  38.472  1.00 29.29  ? 96  TYR L N   1 
ATOM   2359 C CA  . TYR B 2 103 ? 50.442 75.358  37.886  1.00 27.90  ? 96  TYR L CA  1 
ATOM   2360 C C   . TYR B 2 103 ? 49.872 76.522  37.136  1.00 25.13  ? 96  TYR L C   1 
ATOM   2361 O O   . TYR B 2 103 ? 48.760 76.424  36.631  1.00 28.20  ? 96  TYR L O   1 
ATOM   2362 C CB  . TYR B 2 103 ? 51.300 74.463  36.971  1.00 27.67  ? 96  TYR L CB  1 
ATOM   2363 C CG  . TYR B 2 103 ? 51.634 73.117  37.595  1.00 27.11  ? 96  TYR L CG  1 
ATOM   2364 C CD1 . TYR B 2 103 ? 51.732 72.956  38.989  1.00 27.90  ? 96  TYR L CD1 1 
ATOM   2365 C CD2 . TYR B 2 103 ? 51.810 72.001  36.800  1.00 28.32  ? 96  TYR L CD2 1 
ATOM   2366 C CE1 . TYR B 2 103 ? 52.008 71.725  39.548  1.00 29.82  ? 96  TYR L CE1 1 
ATOM   2367 C CE2 . TYR B 2 103 ? 52.076 70.760  37.345  1.00 28.89  ? 96  TYR L CE2 1 
ATOM   2368 C CZ  . TYR B 2 103 ? 52.184 70.629  38.710  1.00 30.22  ? 96  TYR L CZ  1 
ATOM   2369 O OH  . TYR B 2 103 ? 52.468 69.410  39.238  1.00 34.32  ? 96  TYR L OH  1 
ATOM   2370 N N   . THR B 2 104 ? 50.569 77.649  37.177  1.00 23.99  ? 97  THR L N   1 
ATOM   2371 C CA  . THR B 2 104 ? 50.126 78.870  36.497  1.00 25.14  ? 97  THR L CA  1 
ATOM   2372 C C   . THR B 2 104 ? 51.182 79.530  35.611  1.00 26.88  ? 97  THR L C   1 
ATOM   2373 O O   . THR B 2 104 ? 52.375 79.234  35.690  1.00 29.00  ? 97  THR L O   1 
ATOM   2374 C CB  . THR B 2 104 ? 49.593 79.898  37.497  1.00 24.23  ? 97  THR L CB  1 
ATOM   2375 O OG1 . THR B 2 104 ? 50.449 79.912  38.631  1.00 25.61  ? 97  THR L OG1 1 
ATOM   2376 C CG2 . THR B 2 104 ? 48.179 79.506  37.968  1.00 24.20  ? 97  THR L CG2 1 
ATOM   2377 N N   . PHE B 2 105 ? 50.706 80.423  34.748  1.00 27.61  ? 98  PHE L N   1 
ATOM   2378 C CA  . PHE B 2 105 ? 51.561 81.194  33.854  1.00 27.66  ? 98  PHE L CA  1 
ATOM   2379 C C   . PHE B 2 105 ? 51.293 82.694  33.999  1.00 25.28  ? 98  PHE L C   1 
ATOM   2380 O O   . PHE B 2 105 ? 50.145 83.108  34.179  1.00 23.51  ? 98  PHE L O   1 
ATOM   2381 C CB  . PHE B 2 105 ? 51.324 80.789  32.395  1.00 28.57  ? 98  PHE L CB  1 
ATOM   2382 C CG  . PHE B 2 105 ? 51.761 79.389  32.072  1.00 27.23  ? 98  PHE L CG  1 
ATOM   2383 C CD1 . PHE B 2 105 ? 50.933 78.310  32.355  1.00 27.55  ? 98  PHE L CD1 1 
ATOM   2384 C CD2 . PHE B 2 105 ? 52.979 79.159  31.473  1.00 25.00  ? 98  PHE L CD2 1 
ATOM   2385 C CE1 . PHE B 2 105 ? 51.327 77.024  32.042  1.00 27.86  ? 98  PHE L CE1 1 
ATOM   2386 C CE2 . PHE B 2 105 ? 53.394 77.877  31.184  1.00 25.24  ? 98  PHE L CE2 1 
ATOM   2387 C CZ  . PHE B 2 105 ? 52.568 76.810  31.457  1.00 27.11  ? 98  PHE L CZ  1 
ATOM   2388 N N   . GLY B 2 106 ? 52.366 83.482  33.900  1.00 23.70  ? 99  GLY L N   1 
ATOM   2389 C CA  . GLY B 2 106 ? 52.266 84.928  33.799  1.00 25.19  ? 99  GLY L CA  1 
ATOM   2390 C C   . GLY B 2 106 ? 51.787 85.305  32.406  1.00 26.37  ? 99  GLY L C   1 
ATOM   2391 O O   . GLY B 2 106 ? 51.839 84.500  31.477  1.00 30.42  ? 99  GLY L O   1 
ATOM   2392 N N   . GLY B 2 107 ? 51.337 86.543  32.265  1.00 27.68  ? 100 GLY L N   1 
ATOM   2393 C CA  . GLY B 2 107 ? 50.696 87.049  31.041  1.00 27.22  ? 100 GLY L CA  1 
ATOM   2394 C C   . GLY B 2 107 ? 51.582 87.237  29.833  1.00 28.79  ? 100 GLY L C   1 
ATOM   2395 O O   . GLY B 2 107 ? 51.086 87.261  28.708  1.00 31.25  ? 100 GLY L O   1 
ATOM   2396 N N   . GLY B 2 108 ? 52.881 87.400  30.076  1.00 29.65  ? 101 GLY L N   1 
ATOM   2397 C CA  . GLY B 2 108 ? 53.902 87.445  29.026  1.00 30.01  ? 101 GLY L CA  1 
ATOM   2398 C C   . GLY B 2 108 ? 54.522 88.829  28.897  1.00 31.46  ? 101 GLY L C   1 
ATOM   2399 O O   . GLY B 2 108 ? 53.871 89.826  29.166  1.00 30.17  ? 101 GLY L O   1 
ATOM   2400 N N   . THR B 2 109 ? 55.792 88.875  28.493  1.00 32.04  ? 102 THR L N   1 
ATOM   2401 C CA  . THR B 2 109 ? 56.493 90.110  28.189  1.00 30.07  ? 102 THR L CA  1 
ATOM   2402 C C   . THR B 2 109 ? 57.026 89.997  26.769  1.00 32.27  ? 102 THR L C   1 
ATOM   2403 O O   . THR B 2 109 ? 57.705 89.027  26.440  1.00 30.59  ? 102 THR L O   1 
ATOM   2404 C CB  . THR B 2 109 ? 57.639 90.330  29.161  1.00 30.43  ? 102 THR L CB  1 
ATOM   2405 O OG1 . THR B 2 109 ? 57.114 90.424  30.496  1.00 31.82  ? 102 THR L OG1 1 
ATOM   2406 C CG2 . THR B 2 109 ? 58.428 91.611  28.808  1.00 32.06  ? 102 THR L CG2 1 
ATOM   2407 N N   . LYS B 2 110 ? 56.735 90.978  25.923  1.00 35.65  ? 103 LYS L N   1 
ATOM   2408 C CA  . LYS B 2 110 ? 57.266 90.932  24.565  1.00 40.11  ? 103 LYS L CA  1 
ATOM   2409 C C   . LYS B 2 110 ? 58.585 91.656  24.498  1.00 37.16  ? 103 LYS L C   1 
ATOM   2410 O O   . LYS B 2 110 ? 58.643 92.834  24.800  1.00 35.20  ? 103 LYS L O   1 
ATOM   2411 C CB  . LYS B 2 110 ? 56.325 91.530  23.537  1.00 46.74  ? 103 LYS L CB  1 
ATOM   2412 C CG  . LYS B 2 110 ? 56.836 91.252  22.127  1.00 56.62  ? 103 LYS L CG  1 
ATOM   2413 C CD  . LYS B 2 110 ? 55.928 91.785  21.052  1.00 65.86  ? 103 LYS L CD  1 
ATOM   2414 C CE  . LYS B 2 110 ? 56.587 91.613  19.696  1.00 74.06  ? 103 LYS L CE  1 
ATOM   2415 N NZ  . LYS B 2 110 ? 55.653 92.101  18.650  1.00 77.67  ? 103 LYS L NZ  1 
ATOM   2416 N N   . LEU B 2 111 ? 59.633 90.963  24.058  1.00 35.76  ? 104 LEU L N   1 
ATOM   2417 C CA  . LEU B 2 111 ? 60.939 91.588  23.919  1.00 35.94  ? 104 LEU L CA  1 
ATOM   2418 C C   . LEU B 2 111 ? 61.046 92.103  22.493  1.00 35.27  ? 104 LEU L C   1 
ATOM   2419 O O   . LEU B 2 111 ? 60.931 91.342  21.553  1.00 31.54  ? 104 LEU L O   1 
ATOM   2420 C CB  . LEU B 2 111 ? 62.040 90.604  24.221  1.00 37.16  ? 104 LEU L CB  1 
ATOM   2421 C CG  . LEU B 2 111 ? 63.424 91.227  24.366  1.00 40.04  ? 104 LEU L CG  1 
ATOM   2422 C CD1 . LEU B 2 111 ? 63.579 91.987  25.691  1.00 39.43  ? 104 LEU L CD1 1 
ATOM   2423 C CD2 . LEU B 2 111 ? 64.422 90.091  24.265  1.00 40.80  ? 104 LEU L CD2 1 
ATOM   2424 N N   . GLU B 2 112 ? 61.207 93.410  22.360  1.00 37.76  ? 105 GLU L N   1 
ATOM   2425 C CA  . GLU B 2 112 ? 61.162 94.091  21.067  1.00 40.23  ? 105 GLU L CA  1 
ATOM   2426 C C   . GLU B 2 112 ? 62.479 94.743  20.804  1.00 35.94  ? 105 GLU L C   1 
ATOM   2427 O O   . GLU B 2 112 ? 63.340 94.792  21.681  1.00 34.29  ? 105 GLU L O   1 
ATOM   2428 C CB  . GLU B 2 112 ? 60.088 95.178  21.060  1.00 43.22  ? 105 GLU L CB  1 
ATOM   2429 C CG  . GLU B 2 112 ? 58.661 94.661  20.998  1.00 49.23  ? 105 GLU L CG  1 
ATOM   2430 C CD  . GLU B 2 112 ? 57.620 95.652  21.547  1.00 54.53  ? 105 GLU L CD  1 
ATOM   2431 O OE1 . GLU B 2 112 ? 56.447 95.245  21.657  1.00 58.68  ? 105 GLU L OE1 1 
ATOM   2432 O OE2 . GLU B 2 112 ? 57.934 96.821  21.882  1.00 51.89  ? 105 GLU L OE2 1 
ATOM   2433 N N   . ILE B 2 113 ? 62.608 95.267  19.592  1.00 32.09  ? 106 ILE L N   1 
ATOM   2434 C CA  . ILE B 2 113 ? 63.772 96.031  19.228  1.00 32.90  ? 106 ILE L CA  1 
ATOM   2435 C C   . ILE B 2 113 ? 63.575 97.515  19.495  1.00 32.53  ? 106 ILE L C   1 
ATOM   2436 O O   . ILE B 2 113 ? 62.615 98.107  19.025  1.00 31.76  ? 106 ILE L O   1 
ATOM   2437 C CB  . ILE B 2 113 ? 64.118 95.801  17.764  1.00 37.59  ? 106 ILE L CB  1 
ATOM   2438 C CG1 . ILE B 2 113 ? 64.355 94.292  17.566  1.00 41.30  ? 106 ILE L CG1 1 
ATOM   2439 C CG2 . ILE B 2 113 ? 65.332 96.644  17.361  1.00 39.23  ? 106 ILE L CG2 1 
ATOM   2440 C CD1 . ILE B 2 113 ? 65.248 93.923  16.417  1.00 41.71  ? 106 ILE L CD1 1 
ATOM   2441 N N   . LYS B 2 114 ? 64.497 98.101  20.260  1.00 33.47  ? 107 LYS L N   1 
ATOM   2442 C CA  . LYS B 2 114 ? 64.568 99.557  20.427  1.00 35.03  ? 107 LYS L CA  1 
ATOM   2443 C C   . LYS B 2 114 ? 65.302 100.207 19.260  1.00 32.27  ? 107 LYS L C   1 
ATOM   2444 O O   . LYS B 2 114 ? 66.236 99.651  18.700  1.00 31.53  ? 107 LYS L O   1 
ATOM   2445 C CB  . LYS B 2 114 ? 65.262 99.988  21.713  1.00 37.17  ? 107 LYS L CB  1 
ATOM   2446 C CG  . LYS B 2 114 ? 65.505 101.502 21.776  1.00 37.42  ? 107 LYS L CG  1 
ATOM   2447 C CD  . LYS B 2 114 ? 65.618 102.012 23.183  1.00 42.41  ? 107 LYS L CD  1 
ATOM   2448 C CE  . LYS B 2 114 ? 66.807 101.434 23.918  1.00 44.36  ? 107 LYS L CE  1 
ATOM   2449 N NZ  . LYS B 2 114 ? 66.496 101.254 25.370  1.00 48.45  ? 107 LYS L NZ  1 
ATOM   2450 N N   . ARG B 2 115 ? 64.843 101.400 18.922  1.00 29.99  ? 108 ARG L N   1 
ATOM   2451 C CA  . ARG B 2 115 ? 65.487 102.225 17.951  1.00 30.55  ? 108 ARG L CA  1 
ATOM   2452 C C   . ARG B 2 115 ? 64.937 103.619 18.077  1.00 29.41  ? 108 ARG L C   1 
ATOM   2453 O O   . ARG B 2 115 ? 63.957 103.842 18.772  1.00 30.62  ? 108 ARG L O   1 
ATOM   2454 C CB  . ARG B 2 115 ? 65.221 101.684 16.559  1.00 30.37  ? 108 ARG L CB  1 
ATOM   2455 C CG  . ARG B 2 115 ? 63.749 101.460 16.295  1.00 29.45  ? 108 ARG L CG  1 
ATOM   2456 C CD  . ARG B 2 115 ? 63.443 101.776 14.851  1.00 30.55  ? 108 ARG L CD  1 
ATOM   2457 N NE  . ARG B 2 115 ? 63.502 103.211 14.621  1.00 29.28  ? 108 ARG L NE  1 
ATOM   2458 C CZ  . ARG B 2 115 ? 63.723 103.778 13.439  1.00 29.28  ? 108 ARG L CZ  1 
ATOM   2459 N NH1 . ARG B 2 115 ? 63.891 103.043 12.324  1.00 27.07  ? 108 ARG L NH1 1 
ATOM   2460 N NH2 . ARG B 2 115 ? 63.747 105.098 13.367  1.00 29.46  ? 108 ARG L NH2 1 
ATOM   2461 N N   . ALA B 2 116 ? 65.581 104.546 17.385  1.00 29.50  ? 109 ALA L N   1 
ATOM   2462 C CA  . ALA B 2 116 ? 65.213 105.963 17.416  1.00 29.22  ? 109 ALA L CA  1 
ATOM   2463 C C   . ALA B 2 116 ? 63.755 106.210 16.987  1.00 27.89  ? 109 ALA L C   1 
ATOM   2464 O O   . ALA B 2 116 ? 63.180 105.406 16.274  1.00 27.46  ? 109 ALA L O   1 
ATOM   2465 C CB  . ALA B 2 116 ? 66.187 106.765 16.552  1.00 26.80  ? 109 ALA L CB  1 
ATOM   2466 N N   . ASP B 2 117 ? 63.198 107.340 17.415  1.00 28.93  ? 110 ASP L N   1 
ATOM   2467 C CA  . ASP B 2 117 ? 61.864 107.724 17.036  1.00 31.60  ? 110 ASP L CA  1 
ATOM   2468 C C   . ASP B 2 117 ? 61.807 108.020 15.555  1.00 31.10  ? 110 ASP L C   1 
ATOM   2469 O O   . ASP B 2 117 ? 62.793 108.357 14.918  1.00 33.08  ? 110 ASP L O   1 
ATOM   2470 C CB  . ASP B 2 117 ? 61.366 108.926 17.830  1.00 32.56  ? 110 ASP L CB  1 
ATOM   2471 C CG  . ASP B 2 117 ? 61.134 108.599 19.282  1.00 35.79  ? 110 ASP L CG  1 
ATOM   2472 O OD1 . ASP B 2 117 ? 61.173 107.412 19.686  1.00 37.01  ? 110 ASP L OD1 1 
ATOM   2473 O OD2 . ASP B 2 117 ? 60.924 109.550 20.047  1.00 41.99  ? 110 ASP L OD2 1 
ATOM   2474 N N   . ALA B 2 118 ? 60.639 107.773 15.010  1.00 30.43  ? 111 ALA L N   1 
ATOM   2475 C CA  . ALA B 2 118 ? 60.338 108.078 13.628  1.00 31.30  ? 111 ALA L CA  1 
ATOM   2476 C C   . ALA B 2 118 ? 58.855 108.354 13.587  1.00 30.40  ? 111 ALA L C   1 
ATOM   2477 O O   . ALA B 2 118 ? 58.035 107.628 14.165  1.00 30.79  ? 111 ALA L O   1 
ATOM   2478 C CB  . ALA B 2 118 ? 60.716 106.911 12.726  1.00 32.35  ? 111 ALA L CB  1 
ATOM   2479 N N   . ALA B 2 119 ? 58.528 109.450 12.958  1.00 30.13  ? 112 ALA L N   1 
ATOM   2480 C CA  . ALA B 2 119 ? 57.170 109.912 12.894  1.00 29.36  ? 112 ALA L CA  1 
ATOM   2481 C C   . ALA B 2 119 ? 56.464 109.186 11.810  1.00 28.21  ? 112 ALA L C   1 
ATOM   2482 O O   . ALA B 2 119 ? 57.083 108.876 10.785  1.00 27.04  ? 112 ALA L O   1 
ATOM   2483 C CB  . ALA B 2 119 ? 57.171 111.389 12.593  1.00 30.34  ? 112 ALA L CB  1 
ATOM   2484 N N   . PRO B 2 120 ? 55.143 108.945 11.997  1.00 29.33  ? 113 PRO L N   1 
ATOM   2485 C CA  . PRO B 2 120 ? 54.499 108.226 10.927  1.00 29.55  ? 113 PRO L CA  1 
ATOM   2486 C C   . PRO B 2 120 ? 54.154 109.125 9.757   1.00 31.42  ? 113 PRO L C   1 
ATOM   2487 O O   . PRO B 2 120 ? 53.935 110.326 9.933   1.00 32.80  ? 113 PRO L O   1 
ATOM   2488 C CB  . PRO B 2 120 ? 53.226 107.727 11.578  1.00 29.52  ? 113 PRO L CB  1 
ATOM   2489 C CG  . PRO B 2 120 ? 52.853 108.823 12.496  1.00 29.88  ? 113 PRO L CG  1 
ATOM   2490 C CD  . PRO B 2 120 ? 54.158 109.348 13.025  1.00 29.45  ? 113 PRO L CD  1 
ATOM   2491 N N   . SER B 2 121 ? 54.107 108.526 8.575   1.00 29.70  ? 114 SER L N   1 
ATOM   2492 C CA  . SER B 2 121 ? 53.503 109.165 7.425   1.00 31.15  ? 114 SER L CA  1 
ATOM   2493 C C   . SER B 2 121 ? 52.048 108.802 7.566   1.00 30.88  ? 114 SER L C   1 
ATOM   2494 O O   . SER B 2 121 ? 51.703 107.634 7.844   1.00 31.37  ? 114 SER L O   1 
ATOM   2495 C CB  . SER B 2 121 ? 54.038 108.551 6.152   1.00 31.35  ? 114 SER L CB  1 
ATOM   2496 O OG  . SER B 2 121 ? 55.296 108.013 6.418   1.00 33.56  ? 114 SER L OG  1 
ATOM   2497 N N   . VAL B 2 122 ? 51.193 109.783 7.408   1.00 30.95  ? 115 VAL L N   1 
ATOM   2498 C CA  . VAL B 2 122 ? 49.770 109.558 7.598   1.00 33.44  ? 115 VAL L CA  1 
ATOM   2499 C C   . VAL B 2 122 ? 49.040 109.719 6.269   1.00 35.02  ? 115 VAL L C   1 
ATOM   2500 O O   . VAL B 2 122 ? 49.226 110.704 5.577   1.00 35.44  ? 115 VAL L O   1 
ATOM   2501 C CB  . VAL B 2 122 ? 49.213 110.512 8.657   1.00 32.02  ? 115 VAL L CB  1 
ATOM   2502 C CG1 . VAL B 2 122 ? 47.722 110.263 8.884   1.00 31.29  ? 115 VAL L CG1 1 
ATOM   2503 C CG2 . VAL B 2 122 ? 50.004 110.350 9.957   1.00 31.65  ? 115 VAL L CG2 1 
ATOM   2504 N N   . PHE B 2 123 ? 48.199 108.747 5.939   1.00 36.12  ? 116 PHE L N   1 
ATOM   2505 C CA  . PHE B 2 123 ? 47.426 108.785 4.732   1.00 36.78  ? 116 PHE L CA  1 
ATOM   2506 C C   . PHE B 2 123 ? 46.003 108.451 5.076   1.00 38.84  ? 116 PHE L C   1 
ATOM   2507 O O   . PHE B 2 123 ? 45.740 107.635 5.975   1.00 41.22  ? 116 PHE L O   1 
ATOM   2508 C CB  . PHE B 2 123 ? 47.990 107.791 3.725   1.00 38.99  ? 116 PHE L CB  1 
ATOM   2509 C CG  . PHE B 2 123 ? 49.486 107.916 3.526   1.00 43.89  ? 116 PHE L CG  1 
ATOM   2510 C CD1 . PHE B 2 123 ? 50.050 109.079 2.989   1.00 45.38  ? 116 PHE L CD1 1 
ATOM   2511 C CD2 . PHE B 2 123 ? 50.339 106.875 3.880   1.00 43.52  ? 116 PHE L CD2 1 
ATOM   2512 C CE1 . PHE B 2 123 ? 51.432 109.188 2.808   1.00 46.35  ? 116 PHE L CE1 1 
ATOM   2513 C CE2 . PHE B 2 123 ? 51.718 106.982 3.701   1.00 43.74  ? 116 PHE L CE2 1 
ATOM   2514 C CZ  . PHE B 2 123 ? 52.266 108.134 3.167   1.00 43.89  ? 116 PHE L CZ  1 
ATOM   2515 N N   . ILE B 2 124 ? 45.082 109.084 4.355   1.00 38.01  ? 117 ILE L N   1 
ATOM   2516 C CA  . ILE B 2 124 ? 43.658 108.823 4.490   1.00 36.14  ? 117 ILE L CA  1 
ATOM   2517 C C   . ILE B 2 124 ? 43.071 108.329 3.158   1.00 36.68  ? 117 ILE L C   1 
ATOM   2518 O O   . ILE B 2 124 ? 43.525 108.726 2.083   1.00 38.06  ? 117 ILE L O   1 
ATOM   2519 C CB  . ILE B 2 124 ? 42.902 110.050 5.034   1.00 34.60  ? 117 ILE L CB  1 
ATOM   2520 C CG1 . ILE B 2 124 ? 41.528 109.636 5.552   1.00 34.40  ? 117 ILE L CG1 1 
ATOM   2521 C CG2 . ILE B 2 124 ? 42.786 111.150 3.991   1.00 35.67  ? 117 ILE L CG2 1 
ATOM   2522 C CD1 . ILE B 2 124 ? 41.023 110.541 6.656   1.00 34.07  ? 117 ILE L CD1 1 
ATOM   2523 N N   . PHE B 2 125 ? 42.088 107.433 3.271   1.00 34.17  ? 118 PHE L N   1 
ATOM   2524 C CA  . PHE B 2 125 ? 41.438 106.776 2.153   1.00 33.18  ? 118 PHE L CA  1 
ATOM   2525 C C   . PHE B 2 125 ? 39.922 106.835 2.299   1.00 33.59  ? 118 PHE L C   1 
ATOM   2526 O O   . PHE B 2 125 ? 39.338 106.201 3.217   1.00 29.31  ? 118 PHE L O   1 
ATOM   2527 C CB  . PHE B 2 125 ? 41.856 105.309 2.064   1.00 31.63  ? 118 PHE L CB  1 
ATOM   2528 C CG  . PHE B 2 125 ? 43.258 105.138 1.672   1.00 30.37  ? 118 PHE L CG  1 
ATOM   2529 C CD1 . PHE B 2 125 ? 43.636 105.332 0.369   1.00 30.78  ? 118 PHE L CD1 1 
ATOM   2530 C CD2 . PHE B 2 125 ? 44.215 104.828 2.617   1.00 34.15  ? 118 PHE L CD2 1 
ATOM   2531 C CE1 . PHE B 2 125 ? 44.959 105.174 -0.004  1.00 32.81  ? 118 PHE L CE1 1 
ATOM   2532 C CE2 . PHE B 2 125 ? 45.541 104.667 2.266   1.00 34.41  ? 118 PHE L CE2 1 
ATOM   2533 C CZ  . PHE B 2 125 ? 45.916 104.838 0.947   1.00 34.23  ? 118 PHE L CZ  1 
ATOM   2534 N N   . PRO B 2 126 ? 39.279 107.597 1.404   1.00 32.24  ? 119 PRO L N   1 
ATOM   2535 C CA  . PRO B 2 126 ? 37.821 107.579 1.363   1.00 34.72  ? 119 PRO L CA  1 
ATOM   2536 C C   . PRO B 2 126 ? 37.297 106.170 1.038   1.00 33.29  ? 119 PRO L C   1 
ATOM   2537 O O   . PRO B 2 126 ? 38.053 105.344 0.536   1.00 31.03  ? 119 PRO L O   1 
ATOM   2538 C CB  . PRO B 2 126 ? 37.485 108.549 0.222   1.00 33.93  ? 119 PRO L CB  1 
ATOM   2539 C CG  . PRO B 2 126 ? 38.649 109.466 0.142   1.00 34.65  ? 119 PRO L CG  1 
ATOM   2540 C CD  . PRO B 2 126 ? 39.854 108.695 0.611   1.00 32.94  ? 119 PRO L CD  1 
ATOM   2541 N N   . PRO B 2 127 ? 36.013 105.900 1.316   1.00 33.47  ? 120 PRO L N   1 
ATOM   2542 C CA  . PRO B 2 127 ? 35.459 104.652 0.843   1.00 34.75  ? 120 PRO L CA  1 
ATOM   2543 C C   . PRO B 2 127 ? 35.417 104.620 -0.689  1.00 34.12  ? 120 PRO L C   1 
ATOM   2544 O O   . PRO B 2 127 ? 35.248 105.641 -1.353  1.00 30.59  ? 120 PRO L O   1 
ATOM   2545 C CB  . PRO B 2 127 ? 34.040 104.651 1.400   1.00 36.43  ? 120 PRO L CB  1 
ATOM   2546 C CG  . PRO B 2 127 ? 33.699 106.079 1.585   1.00 38.07  ? 120 PRO L CG  1 
ATOM   2547 C CD  . PRO B 2 127 ? 34.989 106.775 1.898   1.00 37.16  ? 120 PRO L CD  1 
ATOM   2548 N N   . SER B 2 128 ? 35.575 103.430 -1.232  1.00 34.10  ? 121 SER L N   1 
ATOM   2549 C CA  . SER B 2 128 ? 35.363 103.228 -2.646  1.00 32.34  ? 121 SER L CA  1 
ATOM   2550 C C   . SER B 2 128 ? 33.862 103.392 -2.958  1.00 34.12  ? 121 SER L C   1 
ATOM   2551 O O   . SER B 2 128 ? 32.983 103.049 -2.141  1.00 30.60  ? 121 SER L O   1 
ATOM   2552 C CB  . SER B 2 128 ? 35.841 101.848 -3.034  1.00 29.89  ? 121 SER L CB  1 
ATOM   2553 O OG  . SER B 2 128 ? 34.999 100.914 -2.415  1.00 28.93  ? 121 SER L OG  1 
ATOM   2554 N N   . ASP B 2 129 ? 33.603 103.947 -4.140  1.00 35.43  ? 122 ASP L N   1 
ATOM   2555 C CA  . ASP B 2 129 ? 32.274 104.017 -4.723  1.00 41.89  ? 122 ASP L CA  1 
ATOM   2556 C C   . ASP B 2 129 ? 31.616 102.640 -4.711  1.00 45.46  ? 122 ASP L C   1 
ATOM   2557 O O   . ASP B 2 129 ? 30.413 102.499 -4.442  1.00 45.83  ? 122 ASP L O   1 
ATOM   2558 C CB  . ASP B 2 129 ? 32.388 104.516 -6.170  1.00 45.55  ? 122 ASP L CB  1 
ATOM   2559 C CG  . ASP B 2 129 ? 32.681 106.000 -6.257  1.00 47.06  ? 122 ASP L CG  1 
ATOM   2560 O OD1 . ASP B 2 129 ? 33.019 106.617 -5.222  1.00 45.96  ? 122 ASP L OD1 1 
ATOM   2561 O OD2 . ASP B 2 129 ? 32.552 106.553 -7.370  1.00 53.29  ? 122 ASP L OD2 1 
ATOM   2562 N N   . GLU B 2 130 ? 32.435 101.634 -4.995  1.00 41.02  ? 123 GLU L N   1 
ATOM   2563 C CA  . GLU B 2 130 ? 32.012 100.261 -4.973  1.00 41.75  ? 123 GLU L CA  1 
ATOM   2564 C C   . GLU B 2 130 ? 31.413 99.825  -3.632  1.00 40.78  ? 123 GLU L C   1 
ATOM   2565 O O   . GLU B 2 130 ? 30.332 99.234  -3.602  1.00 40.61  ? 123 GLU L O   1 
ATOM   2566 C CB  . GLU B 2 130 ? 33.200 99.400  -5.327  1.00 42.91  ? 123 GLU L CB  1 
ATOM   2567 C CG  . GLU B 2 130 ? 32.820 97.962  -5.515  1.00 48.02  ? 123 GLU L CG  1 
ATOM   2568 C CD  . GLU B 2 130 ? 33.974 97.148  -5.997  1.00 53.53  ? 123 GLU L CD  1 
ATOM   2569 O OE1 . GLU B 2 130 ? 34.963 97.751  -6.490  1.00 57.83  ? 123 GLU L OE1 1 
ATOM   2570 O OE2 . GLU B 2 130 ? 33.892 95.909  -5.866  1.00 55.67  ? 123 GLU L OE2 1 
ATOM   2571 N N   . GLN B 2 131 ? 32.126 100.091 -2.541  1.00 37.27  ? 124 GLN L N   1 
ATOM   2572 C CA  . GLN B 2 131 ? 31.592 99.806  -1.206  1.00 38.56  ? 124 GLN L CA  1 
ATOM   2573 C C   . GLN B 2 131 ? 30.297 100.592 -0.927  1.00 39.85  ? 124 GLN L C   1 
ATOM   2574 O O   . GLN B 2 131 ? 29.357 100.036 -0.371  1.00 41.31  ? 124 GLN L O   1 
ATOM   2575 C CB  . GLN B 2 131 ? 32.619 100.094 -0.093  1.00 37.28  ? 124 GLN L CB  1 
ATOM   2576 C CG  . GLN B 2 131 ? 32.166 99.551  1.262   1.00 36.84  ? 124 GLN L CG  1 
ATOM   2577 C CD  . GLN B 2 131 ? 33.059 99.939  2.422   1.00 36.07  ? 124 GLN L CD  1 
ATOM   2578 O OE1 . GLN B 2 131 ? 33.853 100.874 2.331   1.00 37.05  ? 124 GLN L OE1 1 
ATOM   2579 N NE2 . GLN B 2 131 ? 32.904 99.238  3.539   1.00 34.62  ? 124 GLN L NE2 1 
ATOM   2580 N N   . LEU B 2 132 ? 30.270 101.873 -1.304  1.00 40.37  ? 125 LEU L N   1 
ATOM   2581 C CA  . LEU B 2 132 ? 29.103 102.727 -1.090  1.00 44.95  ? 125 LEU L CA  1 
ATOM   2582 C C   . LEU B 2 132 ? 27.848 102.140 -1.739  1.00 52.01  ? 125 LEU L C   1 
ATOM   2583 O O   . LEU B 2 132 ? 26.814 101.995 -1.069  1.00 58.11  ? 125 LEU L O   1 
ATOM   2584 C CB  . LEU B 2 132 ? 29.360 104.149 -1.599  1.00 43.45  ? 125 LEU L CB  1 
ATOM   2585 C CG  . LEU B 2 132 ? 30.352 105.013 -0.830  1.00 43.30  ? 125 LEU L CG  1 
ATOM   2586 C CD1 . LEU B 2 132 ? 30.371 106.378 -1.478  1.00 45.83  ? 125 LEU L CD1 1 
ATOM   2587 C CD2 . LEU B 2 132 ? 30.018 105.135 0.658   1.00 44.51  ? 125 LEU L CD2 1 
ATOM   2588 N N   . LYS B 2 133 ? 27.960 101.752 -3.011  1.00 56.05  ? 126 LYS L N   1 
ATOM   2589 C CA  . LYS B 2 133 ? 26.899 100.995 -3.702  1.00 58.52  ? 126 LYS L CA  1 
ATOM   2590 C C   . LYS B 2 133 ? 26.408 99.828  -2.841  1.00 57.43  ? 126 LYS L C   1 
ATOM   2591 O O   . LYS B 2 133 ? 25.205 99.614  -2.687  1.00 55.95  ? 126 LYS L O   1 
ATOM   2592 C CB  . LYS B 2 133 ? 27.379 100.470 -5.056  1.00 62.07  ? 126 LYS L CB  1 
ATOM   2593 C CG  . LYS B 2 133 ? 27.691 101.549 -6.098  1.00 65.81  ? 126 LYS L CG  1 
ATOM   2594 C CD  . LYS B 2 133 ? 26.487 101.999 -6.932  1.00 70.34  ? 126 LYS L CD  1 
ATOM   2595 C CE  . LYS B 2 133 ? 26.920 102.873 -8.119  1.00 70.74  ? 126 LYS L CE  1 
ATOM   2596 N NZ  . LYS B 2 133 ? 26.208 104.191 -8.209  1.00 69.63  ? 126 LYS L NZ  1 
ATOM   2597 N N   . SER B 2 134 ? 27.342 99.117  -2.227  1.00 54.05  ? 127 SER L N   1 
ATOM   2598 C CA  . SER B 2 134 ? 26.989 98.016  -1.343  1.00 53.38  ? 127 SER L CA  1 
ATOM   2599 C C   . SER B 2 134 ? 26.453 98.400  0.069   1.00 53.11  ? 127 SER L C   1 
ATOM   2600 O O   . SER B 2 134 ? 26.332 97.527  0.919   1.00 54.51  ? 127 SER L O   1 
ATOM   2601 C CB  . SER B 2 134 ? 28.175 97.040  -1.247  1.00 52.14  ? 127 SER L CB  1 
ATOM   2602 O OG  . SER B 2 134 ? 29.064 97.389  -0.207  1.00 51.96  ? 127 SER L OG  1 
ATOM   2603 N N   . GLY B 2 135 ? 26.145 99.672  0.334   1.00 52.54  ? 128 GLY L N   1 
ATOM   2604 C CA  . GLY B 2 135 ? 25.457 100.068 1.587   1.00 50.39  ? 128 GLY L CA  1 
ATOM   2605 C C   . GLY B 2 135 ? 26.271 100.694 2.712   1.00 52.90  ? 128 GLY L C   1 
ATOM   2606 O O   . GLY B 2 135 ? 25.812 101.653 3.335   1.00 52.42  ? 128 GLY L O   1 
ATOM   2607 N N   . THR B 2 136 ? 27.453 100.149 3.006   1.00 53.75  ? 129 THR L N   1 
ATOM   2608 C CA  . THR B 2 136 ? 28.363 100.747 4.010   1.00 53.44  ? 129 THR L CA  1 
ATOM   2609 C C   . THR B 2 136 ? 29.435 101.705 3.434   1.00 50.02  ? 129 THR L C   1 
ATOM   2610 O O   . THR B 2 136 ? 29.627 101.821 2.205   1.00 49.47  ? 129 THR L O   1 
ATOM   2611 C CB  . THR B 2 136 ? 29.029 99.673  4.911   1.00 60.74  ? 129 THR L CB  1 
ATOM   2612 O OG1 . THR B 2 136 ? 29.334 98.509  4.137   1.00 68.26  ? 129 THR L OG1 1 
ATOM   2613 C CG2 . THR B 2 136 ? 28.111 99.290  6.085   1.00 64.90  ? 129 THR L CG2 1 
ATOM   2614 N N   . ALA B 2 137 ? 30.083 102.422 4.356   1.00 43.79  ? 130 ALA L N   1 
ATOM   2615 C CA  . ALA B 2 137 ? 31.135 103.385 4.066   1.00 42.13  ? 130 ALA L CA  1 
ATOM   2616 C C   . ALA B 2 137 ? 32.217 103.254 5.125   1.00 43.35  ? 130 ALA L C   1 
ATOM   2617 O O   . ALA B 2 137 ? 31.993 103.647 6.280   1.00 47.62  ? 130 ALA L O   1 
ATOM   2618 C CB  . ALA B 2 137 ? 30.585 104.801 4.094   1.00 44.01  ? 130 ALA L CB  1 
ATOM   2619 N N   . SER B 2 138 ? 33.375 102.711 4.725   1.00 39.79  ? 131 SER L N   1 
ATOM   2620 C CA  . SER B 2 138 ? 34.557 102.594 5.570   1.00 34.17  ? 131 SER L CA  1 
ATOM   2621 C C   . SER B 2 138 ? 35.566 103.665 5.187   1.00 32.93  ? 131 SER L C   1 
ATOM   2622 O O   . SER B 2 138 ? 35.819 103.856 4.010   1.00 31.23  ? 131 SER L O   1 
ATOM   2623 C CB  . SER B 2 138 ? 35.189 101.231 5.392   1.00 33.89  ? 131 SER L CB  1 
ATOM   2624 O OG  . SER B 2 138 ? 34.300 100.208 5.790   1.00 34.70  ? 131 SER L OG  1 
ATOM   2625 N N   . VAL B 2 139 ? 36.139 104.375 6.163   1.00 32.15  ? 132 VAL L N   1 
ATOM   2626 C CA  . VAL B 2 139 ? 37.248 105.291 5.864   1.00 31.34  ? 132 VAL L CA  1 
ATOM   2627 C C   . VAL B 2 139 ? 38.467 104.721 6.535   1.00 30.12  ? 132 VAL L C   1 
ATOM   2628 O O   . VAL B 2 139 ? 38.404 104.346 7.692   1.00 30.42  ? 132 VAL L O   1 
ATOM   2629 C CB  . VAL B 2 139 ? 37.036 106.737 6.372   1.00 32.22  ? 132 VAL L CB  1 
ATOM   2630 C CG1 . VAL B 2 139 ? 38.062 107.697 5.774   1.00 31.41  ? 132 VAL L CG1 1 
ATOM   2631 C CG2 . VAL B 2 139 ? 35.645 107.224 6.031   1.00 33.59  ? 132 VAL L CG2 1 
ATOM   2632 N N   . VAL B 2 140 ? 39.572 104.687 5.799   1.00 29.66  ? 133 VAL L N   1 
ATOM   2633 C CA  . VAL B 2 140 ? 40.837 104.130 6.282   1.00 30.52  ? 133 VAL L CA  1 
ATOM   2634 C C   . VAL B 2 140 ? 41.916 105.194 6.431   1.00 29.86  ? 133 VAL L C   1 
ATOM   2635 O O   . VAL B 2 140 ? 42.228 105.976 5.508   1.00 27.85  ? 133 VAL L O   1 
ATOM   2636 C CB  . VAL B 2 140 ? 41.363 102.965 5.408   1.00 29.56  ? 133 VAL L CB  1 
ATOM   2637 C CG1 . VAL B 2 140 ? 42.774 102.558 5.830   1.00 30.80  ? 133 VAL L CG1 1 
ATOM   2638 C CG2 . VAL B 2 140 ? 40.439 101.766 5.547   1.00 30.06  ? 133 VAL L CG2 1 
ATOM   2639 N N   . CYS B 2 141 ? 42.497 105.170 7.612   1.00 28.56  ? 134 CYS L N   1 
ATOM   2640 C CA  . CYS B 2 141 ? 43.553 106.051 7.951   1.00 34.10  ? 134 CYS L CA  1 
ATOM   2641 C C   . CYS B 2 141 ? 44.740 105.171 8.265   1.00 32.15  ? 134 CYS L C   1 
ATOM   2642 O O   . CYS B 2 141 ? 44.627 104.250 9.052   1.00 31.26  ? 134 CYS L O   1 
ATOM   2643 C CB  . CYS B 2 141 ? 43.155 106.872 9.160   1.00 38.31  ? 134 CYS L CB  1 
ATOM   2644 S SG  . CYS B 2 141 ? 44.422 108.037 9.606   1.00 45.25  ? 134 CYS L SG  1 
ATOM   2645 N N   . LEU B 2 142 ? 45.881 105.495 7.671   1.00 34.17  ? 135 LEU L N   1 
ATOM   2646 C CA  . LEU B 2 142 ? 47.079 104.683 7.752   1.00 33.02  ? 135 LEU L CA  1 
ATOM   2647 C C   . LEU B 2 142 ? 48.209 105.455 8.373   1.00 30.56  ? 135 LEU L C   1 
ATOM   2648 O O   . LEU B 2 142 ? 48.460 106.609 8.017   1.00 29.83  ? 135 LEU L O   1 
ATOM   2649 C CB  . LEU B 2 142 ? 47.481 104.282 6.341   1.00 37.85  ? 135 LEU L CB  1 
ATOM   2650 C CG  . LEU B 2 142 ? 48.662 103.331 6.160   1.00 41.47  ? 135 LEU L CG  1 
ATOM   2651 C CD1 . LEU B 2 142 ? 48.262 101.943 6.631   1.00 41.65  ? 135 LEU L CD1 1 
ATOM   2652 C CD2 . LEU B 2 142 ? 49.085 103.321 4.700   1.00 42.75  ? 135 LEU L CD2 1 
ATOM   2653 N N   . LEU B 2 143 ? 48.888 104.817 9.313   1.00 28.44  ? 136 LEU L N   1 
ATOM   2654 C CA  . LEU B 2 143 ? 50.054 105.387 9.937   1.00 28.60  ? 136 LEU L CA  1 
ATOM   2655 C C   . LEU B 2 143 ? 51.159 104.435 9.563   1.00 30.93  ? 136 LEU L C   1 
ATOM   2656 O O   . LEU B 2 143 ? 51.138 103.281 9.983   1.00 30.53  ? 136 LEU L O   1 
ATOM   2657 C CB  . LEU B 2 143 ? 49.910 105.445 11.443  1.00 29.29  ? 136 LEU L CB  1 
ATOM   2658 C CG  . LEU B 2 143 ? 49.091 106.573 12.045  1.00 30.31  ? 136 LEU L CG  1 
ATOM   2659 C CD1 . LEU B 2 143 ? 47.662 106.616 11.522  1.00 31.99  ? 136 LEU L CD1 1 
ATOM   2660 C CD2 . LEU B 2 143 ? 49.086 106.425 13.551  1.00 30.23  ? 136 LEU L CD2 1 
ATOM   2661 N N   . ASN B 2 144 ? 52.112 104.913 8.766   1.00 32.52  ? 137 ASN L N   1 
ATOM   2662 C CA  . ASN B 2 144 ? 53.131 104.056 8.206   1.00 35.90  ? 137 ASN L CA  1 
ATOM   2663 C C   . ASN B 2 144 ? 54.495 104.328 8.805   1.00 33.69  ? 137 ASN L C   1 
ATOM   2664 O O   . ASN B 2 144 ? 54.920 105.472 8.877   1.00 31.75  ? 137 ASN L O   1 
ATOM   2665 C CB  . ASN B 2 144 ? 53.159 104.240 6.682   1.00 41.31  ? 137 ASN L CB  1 
ATOM   2666 C CG  . ASN B 2 144 ? 52.904 102.938 5.937   1.00 47.26  ? 137 ASN L CG  1 
ATOM   2667 O OD1 . ASN B 2 144 ? 51.999 102.172 6.302   1.00 52.32  ? 137 ASN L OD1 1 
ATOM   2668 N ND2 . ASN B 2 144 ? 53.687 102.679 4.885   1.00 51.35  ? 137 ASN L ND2 1 
ATOM   2669 N N   . ASN B 2 145 ? 55.137 103.266 9.281   1.00 33.04  ? 138 ASN L N   1 
ATOM   2670 C CA  . ASN B 2 145 ? 56.588 103.228 9.566   1.00 35.12  ? 138 ASN L CA  1 
ATOM   2671 C C   . ASN B 2 145 ? 57.085 104.240 10.585  1.00 32.56  ? 138 ASN L C   1 
ATOM   2672 O O   . ASN B 2 145 ? 57.751 105.199 10.276  1.00 29.18  ? 138 ASN L O   1 
ATOM   2673 C CB  . ASN B 2 145 ? 57.386 103.307 8.263   1.00 38.48  ? 138 ASN L CB  1 
ATOM   2674 C CG  . ASN B 2 145 ? 57.146 102.099 7.377   1.00 43.78  ? 138 ASN L CG  1 
ATOM   2675 O OD1 . ASN B 2 145 ? 57.805 101.066 7.502   1.00 53.56  ? 138 ASN L OD1 1 
ATOM   2676 N ND2 . ASN B 2 145 ? 56.207 102.226 6.476   1.00 47.69  ? 138 ASN L ND2 1 
ATOM   2677 N N   . PHE B 2 146 ? 56.719 104.010 11.828  1.00 34.48  ? 139 PHE L N   1 
ATOM   2678 C CA  . PHE B 2 146 ? 57.026 104.925 12.908  1.00 30.61  ? 139 PHE L CA  1 
ATOM   2679 C C   . PHE B 2 146 ? 57.487 104.146 14.109  1.00 30.14  ? 139 PHE L C   1 
ATOM   2680 O O   . PHE B 2 146 ? 57.452 102.921 14.120  1.00 30.32  ? 139 PHE L O   1 
ATOM   2681 C CB  . PHE B 2 146 ? 55.787 105.742 13.243  1.00 31.66  ? 139 PHE L CB  1 
ATOM   2682 C CG  . PHE B 2 146 ? 54.609 104.933 13.663  1.00 30.22  ? 139 PHE L CG  1 
ATOM   2683 C CD1 . PHE B 2 146 ? 54.403 104.646 14.989  1.00 30.58  ? 139 PHE L CD1 1 
ATOM   2684 C CD2 . PHE B 2 146 ? 53.687 104.484 12.734  1.00 33.20  ? 139 PHE L CD2 1 
ATOM   2685 C CE1 . PHE B 2 146 ? 53.301 103.911 15.414  1.00 30.55  ? 139 PHE L CE1 1 
ATOM   2686 C CE2 . PHE B 2 146 ? 52.570 103.756 13.144  1.00 33.34  ? 139 PHE L CE2 1 
ATOM   2687 C CZ  . PHE B 2 146 ? 52.382 103.472 14.491  1.00 32.04  ? 139 PHE L CZ  1 
ATOM   2688 N N   . TYR B 2 147 ? 57.940 104.874 15.113  1.00 27.93  ? 140 TYR L N   1 
ATOM   2689 C CA  . TYR B 2 147 ? 58.463 104.289 16.313  1.00 27.70  ? 140 TYR L CA  1 
ATOM   2690 C C   . TYR B 2 147 ? 58.389 105.388 17.361  1.00 28.94  ? 140 TYR L C   1 
ATOM   2691 O O   . TYR B 2 147 ? 58.656 106.553 17.017  1.00 31.13  ? 140 TYR L O   1 
ATOM   2692 C CB  . TYR B 2 147 ? 59.922 103.835 16.126  1.00 26.94  ? 140 TYR L CB  1 
ATOM   2693 C CG  . TYR B 2 147 ? 60.359 102.968 17.283  1.00 27.04  ? 140 TYR L CG  1 
ATOM   2694 C CD1 . TYR B 2 147 ? 60.171 101.585 17.244  1.00 28.66  ? 140 TYR L CD1 1 
ATOM   2695 C CD2 . TYR B 2 147 ? 60.879 103.530 18.459  1.00 28.89  ? 140 TYR L CD2 1 
ATOM   2696 C CE1 . TYR B 2 147 ? 60.517 100.777 18.314  1.00 29.40  ? 140 TYR L CE1 1 
ATOM   2697 C CE2 . TYR B 2 147 ? 61.213 102.730 19.552  1.00 30.02  ? 140 TYR L CE2 1 
ATOM   2698 C CZ  . TYR B 2 147 ? 61.031 101.349 19.463  1.00 30.97  ? 140 TYR L CZ  1 
ATOM   2699 O OH  . TYR B 2 147 ? 61.368 100.535 20.508  1.00 36.30  ? 140 TYR L OH  1 
ATOM   2700 N N   . PRO B 2 148 ? 58.026 105.079 18.609  1.00 26.76  ? 141 PRO L N   1 
ATOM   2701 C CA  . PRO B 2 148 ? 57.602 103.765 19.076  1.00 27.55  ? 141 PRO L CA  1 
ATOM   2702 C C   . PRO B 2 148 ? 56.135 103.447 18.743  1.00 29.35  ? 141 PRO L C   1 
ATOM   2703 O O   . PRO B 2 148 ? 55.485 104.176 18.009  1.00 28.47  ? 141 PRO L O   1 
ATOM   2704 C CB  . PRO B 2 148 ? 57.842 103.859 20.611  1.00 26.87  ? 141 PRO L CB  1 
ATOM   2705 C CG  . PRO B 2 148 ? 57.714 105.328 20.927  1.00 26.79  ? 141 PRO L CG  1 
ATOM   2706 C CD  . PRO B 2 148 ? 57.857 106.111 19.648  1.00 25.87  ? 141 PRO L CD  1 
ATOM   2707 N N   . ARG B 2 149 ? 55.641 102.355 19.313  1.00 32.56  ? 142 ARG L N   1 
ATOM   2708 C CA  . ARG B 2 149 ? 54.379 101.747 18.962  1.00 34.72  ? 142 ARG L CA  1 
ATOM   2709 C C   . ARG B 2 149 ? 53.161 102.536 19.414  1.00 35.16  ? 142 ARG L C   1 
ATOM   2710 O O   . ARG B 2 149 ? 52.105 102.526 18.772  1.00 31.18  ? 142 ARG L O   1 
ATOM   2711 C CB  . ARG B 2 149 ? 54.347 100.385 19.612  1.00 39.77  ? 142 ARG L CB  1 
ATOM   2712 C CG  . ARG B 2 149 ? 53.188 99.555  19.150  1.00 47.03  ? 142 ARG L CG  1 
ATOM   2713 C CD  . ARG B 2 149 ? 53.202 98.218  19.844  1.00 53.26  ? 142 ARG L CD  1 
ATOM   2714 N NE  . ARG B 2 149 ? 52.832 97.187  18.895  1.00 62.53  ? 142 ARG L NE  1 
ATOM   2715 C CZ  . ARG B 2 149 ? 52.944 95.880  19.104  1.00 74.57  ? 142 ARG L CZ  1 
ATOM   2716 N NH1 . ARG B 2 149 ? 53.413 95.408  20.268  1.00 74.98  ? 142 ARG L NH1 1 
ATOM   2717 N NH2 . ARG B 2 149 ? 52.573 95.038  18.130  1.00 73.81  ? 142 ARG L NH2 1 
ATOM   2718 N N   . GLU B 2 150 ? 53.330 103.191 20.547  1.00 35.07  ? 143 GLU L N   1 
ATOM   2719 C CA  . GLU B 2 150 ? 52.281 103.913 21.194  1.00 37.29  ? 143 GLU L CA  1 
ATOM   2720 C C   . GLU B 2 150 ? 51.875 105.064 20.257  1.00 38.17  ? 143 GLU L C   1 
ATOM   2721 O O   . GLU B 2 150 ? 52.739 105.801 19.767  1.00 36.57  ? 143 GLU L O   1 
ATOM   2722 C CB  . GLU B 2 150 ? 52.781 104.437 22.544  1.00 42.29  ? 143 GLU L CB  1 
ATOM   2723 C CG  . GLU B 2 150 ? 53.043 103.345 23.582  1.00 45.72  ? 143 GLU L CG  1 
ATOM   2724 C CD  . GLU B 2 150 ? 54.220 102.443 23.222  1.00 53.26  ? 143 GLU L CD  1 
ATOM   2725 O OE1 . GLU B 2 150 ? 55.336 102.967 22.982  1.00 59.85  ? 143 GLU L OE1 1 
ATOM   2726 O OE2 . GLU B 2 150 ? 54.029 101.206 23.137  1.00 59.87  ? 143 GLU L OE2 1 
ATOM   2727 N N   . ALA B 2 151 ? 50.571 105.179 19.994  1.00 34.60  ? 144 ALA L N   1 
ATOM   2728 C CA  . ALA B 2 151 ? 50.035 106.198 19.114  1.00 35.72  ? 144 ALA L CA  1 
ATOM   2729 C C   . ALA B 2 151 ? 48.556 106.422 19.374  1.00 34.54  ? 144 ALA L C   1 
ATOM   2730 O O   . ALA B 2 151 ? 47.808 105.476 19.532  1.00 36.48  ? 144 ALA L O   1 
ATOM   2731 C CB  . ALA B 2 151 ? 50.234 105.794 17.665  1.00 35.32  ? 144 ALA L CB  1 
ATOM   2732 N N   . LYS B 2 152 ? 48.136 107.680 19.383  1.00 34.50  ? 145 LYS L N   1 
ATOM   2733 C CA  . LYS B 2 152 ? 46.731 108.013 19.557  1.00 36.09  ? 145 LYS L CA  1 
ATOM   2734 C C   . LYS B 2 152 ? 46.179 108.407 18.198  1.00 33.53  ? 145 LYS L C   1 
ATOM   2735 O O   . LYS B 2 152 ? 46.720 109.292 17.554  1.00 33.68  ? 145 LYS L O   1 
ATOM   2736 C CB  . LYS B 2 152 ? 46.533 109.135 20.591  1.00 39.28  ? 145 LYS L CB  1 
ATOM   2737 C CG  . LYS B 2 152 ? 45.058 109.447 20.847  1.00 44.12  ? 145 LYS L CG  1 
ATOM   2738 C CD  . LYS B 2 152 ? 44.797 110.358 22.041  1.00 50.28  ? 145 LYS L CD  1 
ATOM   2739 C CE  . LYS B 2 152 ? 45.213 111.801 21.803  1.00 54.25  ? 145 LYS L CE  1 
ATOM   2740 N NZ  . LYS B 2 152 ? 44.893 112.672 22.991  1.00 59.36  ? 145 LYS L NZ  1 
ATOM   2741 N N   . VAL B 2 153 ? 45.100 107.744 17.776  1.00 34.11  ? 146 VAL L N   1 
ATOM   2742 C CA  . VAL B 2 153 ? 44.415 108.038 16.519  1.00 33.07  ? 146 VAL L CA  1 
ATOM   2743 C C   . VAL B 2 153 ? 42.975 108.323 16.800  1.00 33.50  ? 146 VAL L C   1 
ATOM   2744 O O   . VAL B 2 153 ? 42.285 107.524 17.395  1.00 34.74  ? 146 VAL L O   1 
ATOM   2745 C CB  . VAL B 2 153 ? 44.418 106.851 15.561  1.00 33.76  ? 146 VAL L CB  1 
ATOM   2746 C CG1 . VAL B 2 153 ? 43.976 107.302 14.165  1.00 33.28  ? 146 VAL L CG1 1 
ATOM   2747 C CG2 . VAL B 2 153 ? 45.799 106.214 15.518  1.00 34.62  ? 146 VAL L CG2 1 
ATOM   2748 N N   . GLN B 2 154 ? 42.508 109.456 16.318  1.00 34.98  ? 147 GLN L N   1 
ATOM   2749 C CA  . GLN B 2 154 ? 41.167 109.918 16.618  1.00 34.11  ? 147 GLN L CA  1 
ATOM   2750 C C   . GLN B 2 154 ? 40.501 110.335 15.341  1.00 32.29  ? 147 GLN L C   1 
ATOM   2751 O O   . GLN B 2 154 ? 41.136 110.890 14.457  1.00 29.27  ? 147 GLN L O   1 
ATOM   2752 C CB  . GLN B 2 154 ? 41.216 111.125 17.546  1.00 37.01  ? 147 GLN L CB  1 
ATOM   2753 C CG  . GLN B 2 154 ? 41.373 110.775 19.009  1.00 41.44  ? 147 GLN L CG  1 
ATOM   2754 C CD  . GLN B 2 154 ? 41.665 111.983 19.873  1.00 42.73  ? 147 GLN L CD  1 
ATOM   2755 O OE1 . GLN B 2 154 ? 42.364 112.908 19.457  1.00 47.63  ? 147 GLN L OE1 1 
ATOM   2756 N NE2 . GLN B 2 154 ? 41.138 111.978 21.090  1.00 44.33  ? 147 GLN L NE2 1 
ATOM   2757 N N   . TRP B 2 155 ? 39.192 110.131 15.296  1.00 32.50  ? 148 TRP L N   1 
ATOM   2758 C CA  . TRP B 2 155 ? 38.399 110.544 14.161  1.00 31.11  ? 148 TRP L CA  1 
ATOM   2759 C C   . TRP B 2 155 ? 37.428 111.655 14.472  1.00 31.00  ? 148 TRP L C   1 
ATOM   2760 O O   . TRP B 2 155 ? 36.808 111.663 15.535  1.00 30.65  ? 148 TRP L O   1 
ATOM   2761 C CB  . TRP B 2 155 ? 37.617 109.372 13.662  1.00 28.23  ? 148 TRP L CB  1 
ATOM   2762 C CG  . TRP B 2 155 ? 38.393 108.342 12.968  1.00 25.41  ? 148 TRP L CG  1 
ATOM   2763 C CD1 . TRP B 2 155 ? 38.890 107.221 13.503  1.00 23.27  ? 148 TRP L CD1 1 
ATOM   2764 C CD2 . TRP B 2 155 ? 38.674 108.294 11.556  1.00 23.53  ? 148 TRP L CD2 1 
ATOM   2765 N NE1 . TRP B 2 155 ? 39.460 106.446 12.508  1.00 24.49  ? 148 TRP L NE1 1 
ATOM   2766 C CE2 . TRP B 2 155 ? 39.336 107.087 11.308  1.00 23.07  ? 148 TRP L CE2 1 
ATOM   2767 C CE3 . TRP B 2 155 ? 38.403 109.155 10.483  1.00 21.80  ? 148 TRP L CE3 1 
ATOM   2768 C CZ2 . TRP B 2 155 ? 39.753 106.716 10.037  1.00 24.52  ? 148 TRP L CZ2 1 
ATOM   2769 C CZ3 . TRP B 2 155 ? 38.810 108.805 9.233   1.00 21.40  ? 148 TRP L CZ3 1 
ATOM   2770 C CH2 . TRP B 2 155 ? 39.487 107.588 9.004   1.00 23.69  ? 148 TRP L CH2 1 
ATOM   2771 N N   . LYS B 2 156 ? 37.298 112.553 13.491  1.00 32.52  ? 149 LYS L N   1 
ATOM   2772 C CA  . LYS B 2 156 ? 36.469 113.731 13.539  1.00 35.72  ? 149 LYS L CA  1 
ATOM   2773 C C   . LYS B 2 156 ? 35.686 113.776 12.238  1.00 36.26  ? 149 LYS L C   1 
ATOM   2774 O O   . LYS B 2 156 ? 36.265 113.669 11.143  1.00 36.15  ? 149 LYS L O   1 
ATOM   2775 C CB  . LYS B 2 156 ? 37.313 115.001 13.687  1.00 39.82  ? 149 LYS L CB  1 
ATOM   2776 C CG  . LYS B 2 156 ? 37.739 115.343 15.120  1.00 41.07  ? 149 LYS L CG  1 
ATOM   2777 C CD  . LYS B 2 156 ? 39.125 116.005 15.123  1.00 45.86  ? 149 LYS L CD  1 
ATOM   2778 C CE  . LYS B 2 156 ? 39.298 117.162 16.105  1.00 49.36  ? 149 LYS L CE  1 
ATOM   2779 N NZ  . LYS B 2 156 ? 40.046 116.798 17.340  1.00 51.80  ? 149 LYS L NZ  1 
ATOM   2780 N N   . VAL B 2 157 ? 34.366 113.901 12.383  1.00 36.33  ? 150 VAL L N   1 
ATOM   2781 C CA  . VAL B 2 157 ? 33.458 114.038 11.283  1.00 36.62  ? 150 VAL L CA  1 
ATOM   2782 C C   . VAL B 2 157 ? 32.767 115.360 11.500  1.00 37.80  ? 150 VAL L C   1 
ATOM   2783 O O   . VAL B 2 157 ? 32.076 115.535 12.513  1.00 35.97  ? 150 VAL L O   1 
ATOM   2784 C CB  . VAL B 2 157 ? 32.428 112.909 11.255  1.00 38.51  ? 150 VAL L CB  1 
ATOM   2785 C CG1 . VAL B 2 157 ? 31.382 113.154 10.165  1.00 37.59  ? 150 VAL L CG1 1 
ATOM   2786 C CG2 . VAL B 2 157 ? 33.127 111.564 11.054  1.00 38.56  ? 150 VAL L CG2 1 
ATOM   2787 N N   . ASP B 2 158 ? 32.960 116.277 10.551  1.00 37.91  ? 151 ASP L N   1 
ATOM   2788 C CA  . ASP B 2 158 ? 32.474 117.679 10.644  1.00 39.74  ? 151 ASP L CA  1 
ATOM   2789 C C   . ASP B 2 158 ? 32.875 118.304 11.983  1.00 39.20  ? 151 ASP L C   1 
ATOM   2790 O O   . ASP B 2 158 ? 32.051 118.908 12.670  1.00 38.12  ? 151 ASP L O   1 
ATOM   2791 C CB  . ASP B 2 158 ? 30.944 117.767 10.445  1.00 40.18  ? 151 ASP L CB  1 
ATOM   2792 C CG  . ASP B 2 158 ? 30.500 117.507 8.998   1.00 43.08  ? 151 ASP L CG  1 
ATOM   2793 O OD1 . ASP B 2 158 ? 31.313 117.686 8.064   1.00 40.91  ? 151 ASP L OD1 1 
ATOM   2794 O OD2 . ASP B 2 158 ? 29.313 117.139 8.797   1.00 43.71  ? 151 ASP L OD2 1 
ATOM   2795 N N   . ASN B 2 159 ? 34.142 118.112 12.349  1.00 39.79  ? 152 ASN L N   1 
ATOM   2796 C CA  . ASN B 2 159 ? 34.689 118.481 13.664  1.00 40.94  ? 152 ASN L CA  1 
ATOM   2797 C C   . ASN B 2 159 ? 34.158 117.756 14.913  1.00 40.33  ? 152 ASN L C   1 
ATOM   2798 O O   . ASN B 2 159 ? 34.605 118.057 16.030  1.00 38.95  ? 152 ASN L O   1 
ATOM   2799 C CB  . ASN B 2 159 ? 34.583 119.993 13.861  1.00 46.26  ? 152 ASN L CB  1 
ATOM   2800 C CG  . ASN B 2 159 ? 35.843 120.688 13.477  1.00 52.02  ? 152 ASN L CG  1 
ATOM   2801 O OD1 . ASN B 2 159 ? 36.754 120.809 14.301  1.00 59.44  ? 152 ASN L OD1 1 
ATOM   2802 N ND2 . ASN B 2 159 ? 35.939 121.113 12.213  1.00 52.95  ? 152 ASN L ND2 1 
ATOM   2803 N N   . ALA B 2 160 ? 33.239 116.803 14.730  1.00 38.42  ? 153 ALA L N   1 
ATOM   2804 C CA  . ALA B 2 160 ? 32.689 115.986 15.826  1.00 39.04  ? 153 ALA L CA  1 
ATOM   2805 C C   . ALA B 2 160 ? 33.550 114.775 16.094  1.00 37.58  ? 153 ALA L C   1 
ATOM   2806 O O   . ALA B 2 160 ? 33.585 113.846 15.284  1.00 35.62  ? 153 ALA L O   1 
ATOM   2807 C CB  . ALA B 2 160 ? 31.265 115.533 15.509  1.00 39.64  ? 153 ALA L CB  1 
ATOM   2808 N N   . LEU B 2 161 ? 34.236 114.783 17.235  1.00 38.56  ? 154 LEU L N   1 
ATOM   2809 C CA  . LEU B 2 161 ? 35.016 113.632 17.662  1.00 37.84  ? 154 LEU L CA  1 
ATOM   2810 C C   . LEU B 2 161 ? 34.151 112.364 17.755  1.00 36.80  ? 154 LEU L C   1 
ATOM   2811 O O   . LEU B 2 161 ? 33.088 112.392 18.376  1.00 34.63  ? 154 LEU L O   1 
ATOM   2812 C CB  . LEU B 2 161 ? 35.687 113.900 19.000  1.00 39.13  ? 154 LEU L CB  1 
ATOM   2813 C CG  . LEU B 2 161 ? 36.710 112.871 19.497  1.00 40.12  ? 154 LEU L CG  1 
ATOM   2814 C CD1 . LEU B 2 161 ? 37.913 112.770 18.560  1.00 39.42  ? 154 LEU L CD1 1 
ATOM   2815 C CD2 . LEU B 2 161 ? 37.169 113.245 20.905  1.00 38.92  ? 154 LEU L CD2 1 
ATOM   2816 N N   . GLN B 2 162 ? 34.629 111.292 17.109  1.00 34.98  ? 155 GLN L N   1 
ATOM   2817 C CA  . GLN B 2 162 ? 33.959 109.976 17.025  1.00 33.15  ? 155 GLN L CA  1 
ATOM   2818 C C   . GLN B 2 162 ? 34.264 109.023 18.181  1.00 31.04  ? 155 GLN L C   1 
ATOM   2819 O O   . GLN B 2 162 ? 35.344 109.042 18.732  1.00 30.83  ? 155 GLN L O   1 
ATOM   2820 C CB  . GLN B 2 162 ? 34.365 109.282 15.714  1.00 31.44  ? 155 GLN L CB  1 
ATOM   2821 C CG  . GLN B 2 162 ? 33.910 110.003 14.448  1.00 30.61  ? 155 GLN L CG  1 
ATOM   2822 C CD  . GLN B 2 162 ? 32.427 110.310 14.425  1.00 31.18  ? 155 GLN L CD  1 
ATOM   2823 O OE1 . GLN B 2 162 ? 31.591 109.446 14.159  1.00 32.45  ? 155 GLN L OE1 1 
ATOM   2824 N NE2 . GLN B 2 162 ? 32.089 111.548 14.708  1.00 33.96  ? 155 GLN L NE2 1 
ATOM   2825 N N   . SER B 2 163 ? 33.308 108.173 18.535  1.00 30.37  ? 156 SER L N   1 
ATOM   2826 C CA  . SER B 2 163 ? 33.537 107.178 19.582  1.00 31.21  ? 156 SER L CA  1 
ATOM   2827 C C   . SER B 2 163 ? 32.756 105.897 19.290  1.00 30.97  ? 156 SER L C   1 
ATOM   2828 O O   . SER B 2 163 ? 31.557 105.956 19.036  1.00 32.11  ? 156 SER L O   1 
ATOM   2829 C CB  . SER B 2 163 ? 33.149 107.745 20.951  1.00 31.80  ? 156 SER L CB  1 
ATOM   2830 O OG  . SER B 2 163 ? 33.598 106.892 21.998  1.00 33.32  ? 156 SER L OG  1 
ATOM   2831 N N   . GLY B 2 164 ? 33.444 104.761 19.296  1.00 29.28  ? 157 GLY L N   1 
ATOM   2832 C CA  . GLY B 2 164 ? 32.809 103.460 19.108  1.00 30.65  ? 157 GLY L CA  1 
ATOM   2833 C C   . GLY B 2 164 ? 32.629 102.967 17.671  1.00 32.24  ? 157 GLY L C   1 
ATOM   2834 O O   . GLY B 2 164 ? 32.102 101.884 17.490  1.00 33.21  ? 157 GLY L O   1 
ATOM   2835 N N   . ASN B 2 165 ? 33.067 103.712 16.656  1.00 28.51  ? 158 ASN L N   1 
ATOM   2836 C CA  . ASN B 2 165 ? 32.856 103.290 15.266  1.00 27.29  ? 158 ASN L CA  1 
ATOM   2837 C C   . ASN B 2 165 ? 34.150 103.011 14.484  1.00 30.41  ? 158 ASN L C   1 
ATOM   2838 O O   . ASN B 2 165 ? 34.154 102.947 13.241  1.00 31.86  ? 158 ASN L O   1 
ATOM   2839 C CB  . ASN B 2 165 ? 31.940 104.258 14.502  1.00 26.24  ? 158 ASN L CB  1 
ATOM   2840 C CG  . ASN B 2 165 ? 32.318 105.723 14.684  1.00 25.48  ? 158 ASN L CG  1 
ATOM   2841 O OD1 . ASN B 2 165 ? 33.284 106.051 15.358  1.00 22.62  ? 158 ASN L OD1 1 
ATOM   2842 N ND2 . ASN B 2 165 ? 31.512 106.618 14.096  1.00 24.15  ? 158 ASN L ND2 1 
ATOM   2843 N N   . SER B 2 166 ? 35.229 102.766 15.212  1.00 29.53  ? 159 SER L N   1 
ATOM   2844 C CA  . SER B 2 166 ? 36.534 102.585 14.596  1.00 30.45  ? 159 SER L CA  1 
ATOM   2845 C C   . SER B 2 166 ? 37.301 101.450 15.223  1.00 30.51  ? 159 SER L C   1 
ATOM   2846 O O   . SER B 2 166 ? 37.169 101.198 16.393  1.00 26.89  ? 159 SER L O   1 
ATOM   2847 C CB  . SER B 2 166 ? 37.346 103.875 14.659  1.00 29.98  ? 159 SER L CB  1 
ATOM   2848 O OG  . SER B 2 166 ? 37.563 104.251 15.988  1.00 31.56  ? 159 SER L OG  1 
ATOM   2849 N N   . GLN B 2 167 ? 38.092 100.755 14.414  1.00 33.95  ? 160 GLN L N   1 
ATOM   2850 C CA  . GLN B 2 167 ? 39.011 99.715  14.897  1.00 35.70  ? 160 GLN L CA  1 
ATOM   2851 C C   . GLN B 2 167 ? 40.403 100.021 14.353  1.00 31.72  ? 160 GLN L C   1 
ATOM   2852 O O   . GLN B 2 167 ? 40.564 100.516 13.212  1.00 28.83  ? 160 GLN L O   1 
ATOM   2853 C CB  . GLN B 2 167 ? 38.544 98.302  14.477  1.00 40.66  ? 160 GLN L CB  1 
ATOM   2854 C CG  . GLN B 2 167 ? 37.070 98.043  14.792  1.00 47.45  ? 160 GLN L CG  1 
ATOM   2855 C CD  . GLN B 2 167 ? 36.619 96.592  14.590  1.00 51.95  ? 160 GLN L CD  1 
ATOM   2856 O OE1 . GLN B 2 167 ? 36.522 96.116  13.462  1.00 49.80  ? 160 GLN L OE1 1 
ATOM   2857 N NE2 . GLN B 2 167 ? 36.304 95.901  15.689  1.00 53.42  ? 160 GLN L NE2 1 
ATOM   2858 N N   . GLU B 2 168 ? 41.379 99.765  15.215  1.00 30.60  ? 161 GLU L N   1 
ATOM   2859 C CA  . GLU B 2 168 ? 42.798 99.863  14.926  1.00 32.54  ? 161 GLU L CA  1 
ATOM   2860 C C   . GLU B 2 168 ? 43.390 98.472  14.827  1.00 31.39  ? 161 GLU L C   1 
ATOM   2861 O O   . GLU B 2 168 ? 42.941 97.551  15.506  1.00 27.94  ? 161 GLU L O   1 
ATOM   2862 C CB  . GLU B 2 168 ? 43.562 100.570 16.037  1.00 35.63  ? 161 GLU L CB  1 
ATOM   2863 C CG  . GLU B 2 168 ? 43.173 102.010 16.303  1.00 39.75  ? 161 GLU L CG  1 
ATOM   2864 C CD  . GLU B 2 168 ? 44.128 102.685 17.278  1.00 42.32  ? 161 GLU L CD  1 
ATOM   2865 O OE1 . GLU B 2 168 ? 44.617 102.021 18.215  1.00 46.73  ? 161 GLU L OE1 1 
ATOM   2866 O OE2 . GLU B 2 168 ? 44.414 103.876 17.104  1.00 45.27  ? 161 GLU L OE2 1 
ATOM   2867 N N   . SER B 2 169 ? 44.432 98.347  14.011  1.00 29.68  ? 162 SER L N   1 
ATOM   2868 C CA  . SER B 2 169 ? 45.244 97.138  13.954  1.00 27.93  ? 162 SER L CA  1 
ATOM   2869 C C   . SER B 2 169 ? 46.670 97.586  13.697  1.00 30.18  ? 162 SER L C   1 
ATOM   2870 O O   . SER B 2 169 ? 46.900 98.543  12.928  1.00 33.18  ? 162 SER L O   1 
ATOM   2871 C CB  . SER B 2 169 ? 44.739 96.211  12.845  1.00 28.00  ? 162 SER L CB  1 
ATOM   2872 O OG  . SER B 2 169 ? 45.526 95.039  12.719  1.00 25.34  ? 162 SER L OG  1 
ATOM   2873 N N   . VAL B 2 170 ? 47.622 96.902  14.334  1.00 29.62  ? 163 VAL L N   1 
ATOM   2874 C CA  . VAL B 2 170 ? 49.015 97.304  14.303  1.00 31.96  ? 163 VAL L CA  1 
ATOM   2875 C C   . VAL B 2 170 ? 49.819 96.160  13.788  1.00 31.70  ? 163 VAL L C   1 
ATOM   2876 O O   . VAL B 2 170 ? 49.545 95.026  14.161  1.00 30.82  ? 163 VAL L O   1 
ATOM   2877 C CB  . VAL B 2 170 ? 49.536 97.712  15.691  1.00 32.97  ? 163 VAL L CB  1 
ATOM   2878 C CG1 . VAL B 2 170 ? 50.906 98.367  15.572  1.00 31.76  ? 163 VAL L CG1 1 
ATOM   2879 C CG2 . VAL B 2 170 ? 48.569 98.702  16.316  1.00 34.19  ? 163 VAL L CG2 1 
ATOM   2880 N N   . THR B 2 171 ? 50.786 96.462  12.910  1.00 32.91  ? 164 THR L N   1 
ATOM   2881 C CA  . THR B 2 171 ? 51.689 95.432  12.402  1.00 35.20  ? 164 THR L CA  1 
ATOM   2882 C C   . THR B 2 171 ? 52.717 95.096  13.446  1.00 35.58  ? 164 THR L C   1 
ATOM   2883 O O   . THR B 2 171 ? 53.081 95.934  14.253  1.00 36.74  ? 164 THR L O   1 
ATOM   2884 C CB  . THR B 2 171 ? 52.508 95.875  11.189  1.00 34.44  ? 164 THR L CB  1 
ATOM   2885 O OG1 . THR B 2 171 ? 53.248 97.044  11.528  1.00 33.93  ? 164 THR L OG1 1 
ATOM   2886 C CG2 . THR B 2 171 ? 51.629 96.150  9.987   1.00 35.57  ? 164 THR L CG2 1 
ATOM   2887 N N   . GLU B 2 172 ? 53.229 93.883  13.376  1.00 36.59  ? 165 GLU L N   1 
ATOM   2888 C CA  . GLU B 2 172 ? 54.420 93.518  14.122  1.00 36.58  ? 165 GLU L CA  1 
ATOM   2889 C C   . GLU B 2 172 ? 55.576 94.367  13.658  1.00 33.67  ? 165 GLU L C   1 
ATOM   2890 O O   . GLU B 2 172 ? 55.569 94.913  12.559  1.00 35.81  ? 165 GLU L O   1 
ATOM   2891 C CB  . GLU B 2 172 ? 54.746 92.038  13.890  1.00 38.65  ? 165 GLU L CB  1 
ATOM   2892 C CG  . GLU B 2 172 ? 53.721 91.075  14.487  1.00 38.45  ? 165 GLU L CG  1 
ATOM   2893 C CD  . GLU B 2 172 ? 53.692 91.175  16.002  1.00 40.92  ? 165 GLU L CD  1 
ATOM   2894 O OE1 . GLU B 2 172 ? 54.786 91.278  16.599  1.00 41.42  ? 165 GLU L OE1 1 
ATOM   2895 O OE2 . GLU B 2 172 ? 52.588 91.181  16.600  1.00 41.52  ? 165 GLU L OE2 1 
ATOM   2896 N N   . GLN B 2 173 ? 56.595 94.447  14.486  1.00 33.76  ? 166 GLN L N   1 
ATOM   2897 C CA  . GLN B 2 173 ? 57.810 95.190  14.131  1.00 32.72  ? 166 GLN L CA  1 
ATOM   2898 C C   . GLN B 2 173 ? 58.451 94.742  12.818  1.00 33.32  ? 166 GLN L C   1 
ATOM   2899 O O   . GLN B 2 173 ? 58.622 93.547  12.579  1.00 30.00  ? 166 GLN L O   1 
ATOM   2900 C CB  . GLN B 2 173 ? 58.817 95.081  15.250  1.00 31.49  ? 166 GLN L CB  1 
ATOM   2901 C CG  . GLN B 2 173 ? 59.850 96.175  15.240  1.00 31.78  ? 166 GLN L CG  1 
ATOM   2902 C CD  . GLN B 2 173 ? 60.463 96.402  16.608  1.00 29.86  ? 166 GLN L CD  1 
ATOM   2903 O OE1 . GLN B 2 173 ? 60.562 95.482  17.421  1.00 31.34  ? 166 GLN L OE1 1 
ATOM   2904 N NE2 . GLN B 2 173 ? 60.896 97.623  16.859  1.00 29.64  ? 166 GLN L NE2 1 
ATOM   2905 N N   . ASP B 2 174 ? 58.817 95.718  11.995  1.00 34.62  ? 167 ASP L N   1 
ATOM   2906 C CA  . ASP B 2 174 ? 59.244 95.489  10.632  1.00 38.76  ? 167 ASP L CA  1 
ATOM   2907 C C   . ASP B 2 174 ? 60.675 94.924  10.592  1.00 43.72  ? 167 ASP L C   1 
ATOM   2908 O O   . ASP B 2 174 ? 61.585 95.457  11.239  1.00 42.89  ? 167 ASP L O   1 
ATOM   2909 C CB  . ASP B 2 174 ? 59.182 96.816  9.876   1.00 41.77  ? 167 ASP L CB  1 
ATOM   2910 C CG  . ASP B 2 174 ? 59.219 96.643  8.374   1.00 44.40  ? 167 ASP L CG  1 
ATOM   2911 O OD1 . ASP B 2 174 ? 58.210 96.176  7.826   1.00 51.89  ? 167 ASP L OD1 1 
ATOM   2912 O OD2 . ASP B 2 174 ? 60.225 97.008  7.733   1.00 48.97  ? 167 ASP L OD2 1 
ATOM   2913 N N   . SER B 2 175 ? 60.861 93.836  9.842   1.00 47.29  ? 168 SER L N   1 
ATOM   2914 C CA  . SER B 2 175 ? 62.193 93.256  9.559   1.00 50.31  ? 168 SER L CA  1 
ATOM   2915 C C   . SER B 2 175 ? 63.293 94.294  9.384   1.00 51.47  ? 168 SER L C   1 
ATOM   2916 O O   . SER B 2 175 ? 64.274 94.310  10.109  1.00 60.59  ? 168 SER L O   1 
ATOM   2917 C CB  . SER B 2 175 ? 62.154 92.451  8.252   1.00 47.76  ? 168 SER L CB  1 
ATOM   2918 O OG  . SER B 2 175 ? 61.564 91.193  8.449   1.00 50.29  ? 168 SER L OG  1 
ATOM   2919 N N   . LYS B 2 176 ? 63.087 95.169  8.414   1.00 51.62  ? 169 LYS L N   1 
ATOM   2920 C CA  . LYS B 2 176 ? 64.150 95.967  7.852   1.00 50.62  ? 169 LYS L CA  1 
ATOM   2921 C C   . LYS B 2 176 ? 64.462 97.228  8.647   1.00 44.45  ? 169 LYS L C   1 
ATOM   2922 O O   . LYS B 2 176 ? 65.632 97.520  8.904   1.00 46.38  ? 169 LYS L O   1 
ATOM   2923 C CB  . LYS B 2 176 ? 63.790 96.318  6.410   1.00 55.86  ? 169 LYS L CB  1 
ATOM   2924 C CG  . LYS B 2 176 ? 63.575 95.090  5.520   1.00 61.15  ? 169 LYS L CG  1 
ATOM   2925 C CD  . LYS B 2 176 ? 63.495 95.451  4.035   1.00 65.42  ? 169 LYS L CD  1 
ATOM   2926 C CE  . LYS B 2 176 ? 64.865 95.754  3.442   1.00 64.33  ? 169 LYS L CE  1 
ATOM   2927 N NZ  . LYS B 2 176 ? 64.718 96.531  2.186   1.00 69.20  ? 169 LYS L NZ  1 
ATOM   2928 N N   . ASP B 2 177 ? 63.435 97.984  9.013   1.00 39.70  ? 170 ASP L N   1 
ATOM   2929 C CA  . ASP B 2 177 ? 63.648 99.295  9.668   1.00 36.74  ? 170 ASP L CA  1 
ATOM   2930 C C   . ASP B 2 177 ? 63.234 99.342  11.143  1.00 33.58  ? 170 ASP L C   1 
ATOM   2931 O O   . ASP B 2 177 ? 63.373 100.374 11.784  1.00 33.13  ? 170 ASP L O   1 
ATOM   2932 C CB  . ASP B 2 177 ? 62.983 100.428 8.864   1.00 37.28  ? 170 ASP L CB  1 
ATOM   2933 C CG  . ASP B 2 177 ? 61.455 100.319 8.800   1.00 37.42  ? 170 ASP L CG  1 
ATOM   2934 O OD1 . ASP B 2 177 ? 60.848 99.492  9.504   1.00 33.40  ? 170 ASP L OD1 1 
ATOM   2935 O OD2 . ASP B 2 177 ? 60.853 101.073 8.010   1.00 43.96  ? 170 ASP L OD2 1 
ATOM   2936 N N   . SER B 2 178 ? 62.723 98.226  11.656  1.00 32.46  ? 171 SER L N   1 
ATOM   2937 C CA  . SER B 2 178 ? 62.251 98.093  13.054  1.00 34.45  ? 171 SER L CA  1 
ATOM   2938 C C   . SER B 2 178 ? 61.083 98.992  13.478  1.00 32.08  ? 171 SER L C   1 
ATOM   2939 O O   . SER B 2 178 ? 60.849 99.165  14.687  1.00 28.56  ? 171 SER L O   1 
ATOM   2940 C CB  . SER B 2 178 ? 63.428 98.208  14.055  1.00 34.83  ? 171 SER L CB  1 
ATOM   2941 O OG  . SER B 2 178 ? 64.259 97.066  13.965  1.00 33.32  ? 171 SER L OG  1 
ATOM   2942 N N   . THR B 2 179 ? 60.349 99.534  12.496  1.00 30.89  ? 172 THR L N   1 
ATOM   2943 C CA  . THR B 2 179 ? 59.126 100.350 12.742  1.00 30.94  ? 172 THR L CA  1 
ATOM   2944 C C   . THR B 2 179 ? 57.795 99.555  12.836  1.00 29.30  ? 172 THR L C   1 
ATOM   2945 O O   . THR B 2 179 ? 57.742 98.373  12.571  1.00 27.51  ? 172 THR L O   1 
ATOM   2946 C CB  . THR B 2 179 ? 58.932 101.444 11.658  1.00 32.04  ? 172 THR L CB  1 
ATOM   2947 O OG1 . THR B 2 179 ? 58.819 100.852 10.340  1.00 32.10  ? 172 THR L OG1 1 
ATOM   2948 C CG2 . THR B 2 179 ? 60.040 102.480 11.724  1.00 31.65  ? 172 THR L CG2 1 
ATOM   2949 N N   . TYR B 2 180 ? 56.737 100.260 13.232  1.00 30.05  ? 173 TYR L N   1 
ATOM   2950 C CA  . TYR B 2 180 ? 55.353 99.793  13.192  1.00 31.57  ? 173 TYR L CA  1 
ATOM   2951 C C   . TYR B 2 180 ? 54.525 100.560 12.136  1.00 31.24  ? 173 TYR L C   1 
ATOM   2952 O O   . TYR B 2 180 ? 54.858 101.674 11.734  1.00 32.21  ? 173 TYR L O   1 
ATOM   2953 C CB  . TYR B 2 180 ? 54.694 99.969  14.577  1.00 31.68  ? 173 TYR L CB  1 
ATOM   2954 C CG  . TYR B 2 180 ? 55.415 99.214  15.679  1.00 33.22  ? 173 TYR L CG  1 
ATOM   2955 C CD1 . TYR B 2 180 ? 55.157 97.869  15.909  1.00 34.43  ? 173 TYR L CD1 1 
ATOM   2956 C CD2 . TYR B 2 180 ? 56.384 99.821  16.458  1.00 32.52  ? 173 TYR L CD2 1 
ATOM   2957 C CE1 . TYR B 2 180 ? 55.827 97.158  16.898  1.00 31.61  ? 173 TYR L CE1 1 
ATOM   2958 C CE2 . TYR B 2 180 ? 57.063 99.109  17.444  1.00 31.87  ? 173 TYR L CE2 1 
ATOM   2959 C CZ  . TYR B 2 180 ? 56.771 97.781  17.661  1.00 32.16  ? 173 TYR L CZ  1 
ATOM   2960 O OH  . TYR B 2 180 ? 57.419 97.067  18.654  1.00 36.12  ? 173 TYR L OH  1 
ATOM   2961 N N   . SER B 2 181 ? 53.429 99.946  11.708  1.00 29.90  ? 174 SER L N   1 
ATOM   2962 C CA  . SER B 2 181 ? 52.392 100.632 10.944  1.00 28.78  ? 174 SER L CA  1 
ATOM   2963 C C   . SER B 2 181 ? 51.045 100.279 11.549  1.00 29.02  ? 174 SER L C   1 
ATOM   2964 O O   . SER B 2 181 ? 50.920 99.284  12.284  1.00 30.39  ? 174 SER L O   1 
ATOM   2965 C CB  . SER B 2 181 ? 52.499 100.276 9.451   1.00 27.76  ? 174 SER L CB  1 
ATOM   2966 O OG  . SER B 2 181 ? 53.821 100.578 9.025   1.00 24.13  ? 174 SER L OG  1 
ATOM   2967 N N   . LEU B 2 182 ? 50.045 101.105 11.274  1.00 28.83  ? 175 LEU L N   1 
ATOM   2968 C CA  . LEU B 2 182 ? 48.777 101.007 11.983  1.00 30.14  ? 175 LEU L CA  1 
ATOM   2969 C C   . LEU B 2 182 ? 47.659 101.439 11.072  1.00 29.85  ? 175 LEU L C   1 
ATOM   2970 O O   . LEU B 2 182 ? 47.822 102.381 10.311  1.00 34.20  ? 175 LEU L O   1 
ATOM   2971 C CB  . LEU B 2 182 ? 48.816 101.877 13.252  1.00 30.48  ? 175 LEU L CB  1 
ATOM   2972 C CG  . LEU B 2 182 ? 47.653 101.814 14.247  1.00 28.88  ? 175 LEU L CG  1 
ATOM   2973 C CD1 . LEU B 2 182 ? 48.133 102.253 15.608  1.00 30.31  ? 175 LEU L CD1 1 
ATOM   2974 C CD2 . LEU B 2 182 ? 46.476 102.690 13.887  1.00 29.50  ? 175 LEU L CD2 1 
ATOM   2975 N N   . SER B 2 183 ? 46.528 100.755 11.157  1.00 29.12  ? 176 SER L N   1 
ATOM   2976 C CA  . SER B 2 183 ? 45.361 101.090 10.361  1.00 29.57  ? 176 SER L CA  1 
ATOM   2977 C C   . SER B 2 183 ? 44.302 101.487 11.340  1.00 28.08  ? 176 SER L C   1 
ATOM   2978 O O   . SER B 2 183 ? 44.111 100.772 12.301  1.00 27.74  ? 176 SER L O   1 
ATOM   2979 C CB  . SER B 2 183 ? 44.868 99.893  9.548   1.00 29.35  ? 176 SER L CB  1 
ATOM   2980 O OG  . SER B 2 183 ? 44.407 98.827  10.380  1.00 31.63  ? 176 SER L OG  1 
ATOM   2981 N N   . SER B 2 184 ? 43.653 102.634 11.124  1.00 26.55  ? 177 SER L N   1 
ATOM   2982 C CA  . SER B 2 184 ? 42.386 102.922 11.798  1.00 26.47  ? 177 SER L CA  1 
ATOM   2983 C C   . SER B 2 184 ? 41.316 103.005 10.763  1.00 26.63  ? 177 SER L C   1 
ATOM   2984 O O   . SER B 2 184 ? 41.457 103.729 9.763   1.00 25.99  ? 177 SER L O   1 
ATOM   2985 C CB  . SER B 2 184 ? 42.374 104.202 12.632  1.00 26.03  ? 177 SER L CB  1 
ATOM   2986 O OG  . SER B 2 184 ? 41.309 104.142 13.570  1.00 24.10  ? 177 SER L OG  1 
ATOM   2987 N N   . THR B 2 185 ? 40.256 102.247 11.027  1.00 26.14  ? 178 THR L N   1 
ATOM   2988 C CA  . THR B 2 185 ? 39.131 102.127 10.143  1.00 28.23  ? 178 THR L CA  1 
ATOM   2989 C C   . THR B 2 185 ? 37.856 102.637 10.809  1.00 28.10  ? 178 THR L C   1 
ATOM   2990 O O   . THR B 2 185 ? 37.420 102.124 11.821  1.00 26.90  ? 178 THR L O   1 
ATOM   2991 C CB  . THR B 2 185 ? 38.982 100.667 9.676   1.00 29.12  ? 178 THR L CB  1 
ATOM   2992 O OG1 . THR B 2 185 ? 40.221 100.286 9.089   1.00 27.41  ? 178 THR L OG1 1 
ATOM   2993 C CG2 . THR B 2 185 ? 37.902 100.543 8.632   1.00 28.08  ? 178 THR L CG2 1 
ATOM   2994 N N   . LEU B 2 186 ? 37.273 103.656 10.203  1.00 29.76  ? 179 LEU L N   1 
ATOM   2995 C CA  . LEU B 2 186 ? 36.033 104.241 10.649  1.00 30.81  ? 179 LEU L CA  1 
ATOM   2996 C C   . LEU B 2 186 ? 34.941 103.600 9.793   1.00 32.47  ? 179 LEU L C   1 
ATOM   2997 O O   . LEU B 2 186 ? 34.941 103.720 8.553   1.00 29.90  ? 179 LEU L O   1 
ATOM   2998 C CB  . LEU B 2 186 ? 36.079 105.763 10.453  1.00 29.62  ? 179 LEU L CB  1 
ATOM   2999 C CG  . LEU B 2 186 ? 34.897 106.545 11.003  1.00 32.17  ? 179 LEU L CG  1 
ATOM   3000 C CD1 . LEU B 2 186 ? 34.957 106.647 12.520  1.00 33.85  ? 179 LEU L CD1 1 
ATOM   3001 C CD2 . LEU B 2 186 ? 34.855 107.944 10.404  1.00 33.64  ? 179 LEU L CD2 1 
ATOM   3002 N N   . THR B 2 187 ? 34.003 102.942 10.450  1.00 35.14  ? 180 THR L N   1 
ATOM   3003 C CA  . THR B 2 187 ? 32.936 102.258 9.746   1.00 38.85  ? 180 THR L CA  1 
ATOM   3004 C C   . THR B 2 187 ? 31.587 102.965 9.970   1.00 38.01  ? 180 THR L C   1 
ATOM   3005 O O   . THR B 2 187 ? 31.156 103.171 11.096  1.00 39.18  ? 180 THR L O   1 
ATOM   3006 C CB  . THR B 2 187 ? 32.951 100.776 10.140  1.00 41.12  ? 180 THR L CB  1 
ATOM   3007 O OG1 . THR B 2 187 ? 34.288 100.271 9.955   1.00 41.20  ? 180 THR L OG1 1 
ATOM   3008 C CG2 . THR B 2 187 ? 31.984 99.993  9.287   1.00 41.67  ? 180 THR L CG2 1 
ATOM   3009 N N   . LEU B 2 188 ? 30.967 103.388 8.874   1.00 41.32  ? 181 LEU L N   1 
ATOM   3010 C CA  . LEU B 2 188 ? 29.673 104.058 8.897   1.00 40.89  ? 181 LEU L CA  1 
ATOM   3011 C C   . LEU B 2 188 ? 28.762 103.382 7.919   1.00 41.35  ? 181 LEU L C   1 
ATOM   3012 O O   . LEU B 2 188 ? 29.234 102.629 7.060   1.00 39.94  ? 181 LEU L O   1 
ATOM   3013 C CB  . LEU B 2 188 ? 29.793 105.519 8.475   1.00 42.31  ? 181 LEU L CB  1 
ATOM   3014 C CG  . LEU B 2 188 ? 30.611 106.481 9.333   1.00 44.29  ? 181 LEU L CG  1 
ATOM   3015 C CD1 . LEU B 2 188 ? 32.084 106.429 8.970   1.00 45.91  ? 181 LEU L CD1 1 
ATOM   3016 C CD2 . LEU B 2 188 ? 30.117 107.899 9.129   1.00 43.11  ? 181 LEU L CD2 1 
ATOM   3017 N N   . SER B 2 189 ? 27.460 103.664 8.054   1.00 42.06  ? 182 SER L N   1 
ATOM   3018 C CA  . SER B 2 189 ? 26.442 103.296 7.050   1.00 43.32  ? 182 SER L CA  1 
ATOM   3019 C C   . SER B 2 189 ? 26.513 104.324 5.933   1.00 44.77  ? 182 SER L C   1 
ATOM   3020 O O   . SER B 2 189 ? 26.932 105.458 6.189   1.00 43.30  ? 182 SER L O   1 
ATOM   3021 C CB  . SER B 2 189 ? 25.055 103.318 7.674   1.00 45.05  ? 182 SER L CB  1 
ATOM   3022 O OG  . SER B 2 189 ? 24.695 104.643 8.037   1.00 47.18  ? 182 SER L OG  1 
ATOM   3023 N N   . LYS B 2 190 ? 26.122 103.952 4.707   1.00 43.57  ? 183 LYS L N   1 
ATOM   3024 C CA  . LYS B 2 190 ? 26.225 104.903 3.582   1.00 45.98  ? 183 LYS L CA  1 
ATOM   3025 C C   . LYS B 2 190 ? 25.473 106.177 3.900   1.00 45.69  ? 183 LYS L C   1 
ATOM   3026 O O   . LYS B 2 190 ? 26.001 107.275 3.734   1.00 47.63  ? 183 LYS L O   1 
ATOM   3027 C CB  . LYS B 2 190 ? 25.722 104.344 2.235   1.00 46.92  ? 183 LYS L CB  1 
ATOM   3028 C CG  . LYS B 2 190 ? 25.605 105.425 1.156   1.00 51.81  ? 183 LYS L CG  1 
ATOM   3029 C CD  . LYS B 2 190 ? 25.856 104.930 -0.260  1.00 59.44  ? 183 LYS L CD  1 
ATOM   3030 C CE  . LYS B 2 190 ? 24.689 104.152 -0.844  1.00 63.68  ? 183 LYS L CE  1 
ATOM   3031 N NZ  . LYS B 2 190 ? 23.591 105.047 -1.310  1.00 72.33  ? 183 LYS L NZ  1 
ATOM   3032 N N   . ALA B 2 191 ? 24.236 106.015 4.356   1.00 47.50  ? 184 ALA L N   1 
ATOM   3033 C CA  . ALA B 2 191 ? 23.372 107.148 4.692   1.00 45.68  ? 184 ALA L CA  1 
ATOM   3034 C C   . ALA B 2 191 ? 24.052 108.113 5.687   1.00 47.23  ? 184 ALA L C   1 
ATOM   3035 O O   . ALA B 2 191 ? 23.977 109.330 5.526   1.00 41.94  ? 184 ALA L O   1 
ATOM   3036 C CB  . ALA B 2 191 ? 22.037 106.651 5.224   1.00 44.18  ? 184 ALA L CB  1 
ATOM   3037 N N   . ASP B 2 192 ? 24.736 107.554 6.688   1.00 51.10  ? 185 ASP L N   1 
ATOM   3038 C CA  . ASP B 2 192 ? 25.476 108.356 7.671   1.00 52.31  ? 185 ASP L CA  1 
ATOM   3039 C C   . ASP B 2 192 ? 26.582 109.072 6.961   1.00 47.77  ? 185 ASP L C   1 
ATOM   3040 O O   . ASP B 2 192 ? 26.724 110.280 7.109   1.00 45.02  ? 185 ASP L O   1 
ATOM   3041 C CB  . ASP B 2 192 ? 26.106 107.502 8.783   1.00 56.24  ? 185 ASP L CB  1 
ATOM   3042 C CG  . ASP B 2 192 ? 25.113 107.074 9.848   1.00 63.40  ? 185 ASP L CG  1 
ATOM   3043 O OD1 . ASP B 2 192 ? 24.027 107.699 9.990   1.00 64.89  ? 185 ASP L OD1 1 
ATOM   3044 O OD2 . ASP B 2 192 ? 25.444 106.092 10.556  1.00 65.32  ? 185 ASP L OD2 1 
ATOM   3045 N N   . TYR B 2 193 ? 27.351 108.320 6.175   1.00 41.65  ? 186 TYR L N   1 
ATOM   3046 C CA  . TYR B 2 193 ? 28.499 108.882 5.492   1.00 42.42  ? 186 TYR L CA  1 
ATOM   3047 C C   . TYR B 2 193 ? 28.152 110.087 4.612   1.00 44.28  ? 186 TYR L C   1 
ATOM   3048 O O   . TYR B 2 193 ? 28.920 111.075 4.565   1.00 41.65  ? 186 TYR L O   1 
ATOM   3049 C CB  . TYR B 2 193 ? 29.216 107.826 4.670   1.00 42.00  ? 186 TYR L CB  1 
ATOM   3050 C CG  . TYR B 2 193 ? 30.380 108.352 3.849   1.00 38.41  ? 186 TYR L CG  1 
ATOM   3051 C CD1 . TYR B 2 193 ? 31.634 108.511 4.420   1.00 37.68  ? 186 TYR L CD1 1 
ATOM   3052 C CD2 . TYR B 2 193 ? 30.225 108.663 2.491   1.00 37.05  ? 186 TYR L CD2 1 
ATOM   3053 C CE1 . TYR B 2 193 ? 32.708 108.965 3.681   1.00 36.26  ? 186 TYR L CE1 1 
ATOM   3054 C CE2 . TYR B 2 193 ? 31.294 109.106 1.741   1.00 34.87  ? 186 TYR L CE2 1 
ATOM   3055 C CZ  . TYR B 2 193 ? 32.535 109.247 2.347   1.00 35.14  ? 186 TYR L CZ  1 
ATOM   3056 O OH  . TYR B 2 193 ? 33.609 109.724 1.637   1.00 35.32  ? 186 TYR L OH  1 
ATOM   3057 N N   . GLU B 2 194 ? 26.997 110.009 3.950   1.00 45.04  ? 187 GLU L N   1 
ATOM   3058 C CA  . GLU B 2 194 ? 26.596 111.030 2.976   1.00 48.40  ? 187 GLU L CA  1 
ATOM   3059 C C   . GLU B 2 194 ? 26.102 112.338 3.642   1.00 47.69  ? 187 GLU L C   1 
ATOM   3060 O O   . GLU B 2 194 ? 26.146 113.419 3.026   1.00 44.27  ? 187 GLU L O   1 
ATOM   3061 C CB  . GLU B 2 194 ? 25.566 110.467 1.988   1.00 52.59  ? 187 GLU L CB  1 
ATOM   3062 C CG  . GLU B 2 194 ? 25.922 109.108 1.367   1.00 54.84  ? 187 GLU L CG  1 
ATOM   3063 C CD  . GLU B 2 194 ? 26.532 109.190 -0.014  1.00 58.02  ? 187 GLU L CD  1 
ATOM   3064 O OE1 . GLU B 2 194 ? 26.106 108.406 -0.893  1.00 57.32  ? 187 GLU L OE1 1 
ATOM   3065 O OE2 . GLU B 2 194 ? 27.443 110.020 -0.214  1.00 59.99  ? 187 GLU L OE2 1 
ATOM   3066 N N   . LYS B 2 195 ? 25.696 112.251 4.907   1.00 47.41  ? 188 LYS L N   1 
ATOM   3067 C CA  . LYS B 2 195 ? 25.178 113.425 5.647   1.00 51.43  ? 188 LYS L CA  1 
ATOM   3068 C C   . LYS B 2 195 ? 26.215 114.402 6.135   1.00 50.15  ? 188 LYS L C   1 
ATOM   3069 O O   . LYS B 2 195 ? 25.850 115.490 6.580   1.00 53.31  ? 188 LYS L O   1 
ATOM   3070 C CB  . LYS B 2 195 ? 24.305 112.999 6.839   1.00 56.79  ? 188 LYS L CB  1 
ATOM   3071 C CG  . LYS B 2 195 ? 22.840 112.857 6.451   1.00 65.04  ? 188 LYS L CG  1 
ATOM   3072 C CD  . LYS B 2 195 ? 22.032 112.023 7.427   1.00 68.72  ? 188 LYS L CD  1 
ATOM   3073 C CE  . LYS B 2 195 ? 20.684 111.652 6.819   1.00 76.85  ? 188 LYS L CE  1 
ATOM   3074 N NZ  . LYS B 2 195 ? 20.279 110.261 7.177   1.00 82.99  ? 188 LYS L NZ  1 
ATOM   3075 N N   . HIS B 2 196 ? 27.489 114.019 6.064   1.00 47.93  ? 189 HIS L N   1 
ATOM   3076 C CA  . HIS B 2 196 ? 28.597 114.823 6.601   1.00 46.64  ? 189 HIS L CA  1 
ATOM   3077 C C   . HIS B 2 196 ? 29.611 115.098 5.511   1.00 42.99  ? 189 HIS L C   1 
ATOM   3078 O O   . HIS B 2 196 ? 29.733 114.310 4.577   1.00 39.97  ? 189 HIS L O   1 
ATOM   3079 C CB  . HIS B 2 196 ? 29.232 114.083 7.774   1.00 47.17  ? 189 HIS L CB  1 
ATOM   3080 C CG  . HIS B 2 196 ? 28.261 113.771 8.875   1.00 48.42  ? 189 HIS L CG  1 
ATOM   3081 N ND1 . HIS B 2 196 ? 27.867 114.713 9.803   1.00 47.17  ? 189 HIS L ND1 1 
ATOM   3082 C CD2 . HIS B 2 196 ? 27.592 112.633 9.183   1.00 45.12  ? 189 HIS L CD2 1 
ATOM   3083 C CE1 . HIS B 2 196 ? 27.009 114.162 10.645  1.00 49.19  ? 189 HIS L CE1 1 
ATOM   3084 N NE2 . HIS B 2 196 ? 26.833 112.899 10.295  1.00 47.54  ? 189 HIS L NE2 1 
ATOM   3085 N N   . LYS B 2 197 ? 30.315 116.221 5.602   1.00 43.33  ? 190 LYS L N   1 
ATOM   3086 C CA  . LYS B 2 197 ? 31.305 116.561 4.576   1.00 45.53  ? 190 LYS L CA  1 
ATOM   3087 C C   . LYS B 2 197 ? 32.768 116.254 4.966   1.00 42.89  ? 190 LYS L C   1 
ATOM   3088 O O   . LYS B 2 197 ? 33.518 115.686 4.161   1.00 42.10  ? 190 LYS L O   1 
ATOM   3089 C CB  . LYS B 2 197 ? 31.112 117.996 4.040   1.00 52.28  ? 190 LYS L CB  1 
ATOM   3090 C CG  . LYS B 2 197 ? 31.170 119.127 5.061   1.00 60.79  ? 190 LYS L CG  1 
ATOM   3091 C CD  . LYS B 2 197 ? 31.650 120.459 4.454   1.00 64.51  ? 190 LYS L CD  1 
ATOM   3092 C CE  . LYS B 2 197 ? 31.322 121.668 5.337   1.00 64.04  ? 190 LYS L CE  1 
ATOM   3093 N NZ  . LYS B 2 197 ? 31.734 121.493 6.763   1.00 62.21  ? 190 LYS L NZ  1 
ATOM   3094 N N   . VAL B 2 198 ? 33.171 116.595 6.187   1.00 39.85  ? 191 VAL L N   1 
ATOM   3095 C CA  . VAL B 2 198 ? 34.603 116.532 6.576   1.00 35.97  ? 191 VAL L CA  1 
ATOM   3096 C C   . VAL B 2 198 ? 34.943 115.299 7.407   1.00 34.46  ? 191 VAL L C   1 
ATOM   3097 O O   . VAL B 2 198 ? 34.367 115.101 8.473   1.00 30.94  ? 191 VAL L O   1 
ATOM   3098 C CB  . VAL B 2 198 ? 35.049 117.761 7.387   1.00 35.28  ? 191 VAL L CB  1 
ATOM   3099 C CG1 . VAL B 2 198 ? 36.545 117.685 7.686   1.00 35.58  ? 191 VAL L CG1 1 
ATOM   3100 C CG2 . VAL B 2 198 ? 34.739 119.057 6.647   1.00 35.34  ? 191 VAL L CG2 1 
ATOM   3101 N N   . TYR B 2 199 ? 35.925 114.532 6.929   1.00 33.19  ? 192 TYR L N   1 
ATOM   3102 C CA  . TYR B 2 199 ? 36.434 113.335 7.586   1.00 32.46  ? 192 TYR L CA  1 
ATOM   3103 C C   . TYR B 2 199 ? 37.899 113.589 7.860   1.00 32.37  ? 192 TYR L C   1 
ATOM   3104 O O   . TYR B 2 199 ? 38.660 113.919 6.952   1.00 34.85  ? 192 TYR L O   1 
ATOM   3105 C CB  . TYR B 2 199 ? 36.226 112.084 6.708   1.00 32.14  ? 192 TYR L CB  1 
ATOM   3106 C CG  . TYR B 2 199 ? 34.760 111.755 6.598   1.00 30.87  ? 192 TYR L CG  1 
ATOM   3107 C CD1 . TYR B 2 199 ? 34.147 110.943 7.538   1.00 29.95  ? 192 TYR L CD1 1 
ATOM   3108 C CD2 . TYR B 2 199 ? 33.964 112.328 5.609   1.00 31.98  ? 192 TYR L CD2 1 
ATOM   3109 C CE1 . TYR B 2 199 ? 32.788 110.686 7.493   1.00 28.86  ? 192 TYR L CE1 1 
ATOM   3110 C CE2 . TYR B 2 199 ? 32.593 112.059 5.550   1.00 30.61  ? 192 TYR L CE2 1 
ATOM   3111 C CZ  . TYR B 2 199 ? 32.018 111.239 6.503   1.00 29.48  ? 192 TYR L CZ  1 
ATOM   3112 O OH  . TYR B 2 199 ? 30.662 110.980 6.492   1.00 30.04  ? 192 TYR L OH  1 
ATOM   3113 N N   . ALA B 2 200 ? 38.289 113.464 9.120   1.00 31.08  ? 193 ALA L N   1 
ATOM   3114 C CA  . ALA B 2 200 ? 39.647 113.764 9.518   1.00 31.34  ? 193 ALA L CA  1 
ATOM   3115 C C   . ALA B 2 200 ? 40.108 112.743 10.499  1.00 31.85  ? 193 ALA L C   1 
ATOM   3116 O O   . ALA B 2 200 ? 39.415 112.427 11.455  1.00 35.00  ? 193 ALA L O   1 
ATOM   3117 C CB  . ALA B 2 200 ? 39.737 115.143 10.138  1.00 29.99  ? 193 ALA L CB  1 
ATOM   3118 N N   . CYS B 2 201 ? 41.290 112.232 10.228  1.00 34.33  ? 194 CYS L N   1 
ATOM   3119 C CA  . CYS B 2 201 ? 42.021 111.368 11.104  1.00 36.53  ? 194 CYS L CA  1 
ATOM   3120 C C   . CYS B 2 201 ? 43.105 112.237 11.814  1.00 36.86  ? 194 CYS L C   1 
ATOM   3121 O O   . CYS B 2 201 ? 43.955 112.846 11.146  1.00 34.35  ? 194 CYS L O   1 
ATOM   3122 C CB  . CYS B 2 201 ? 42.640 110.304 10.233  1.00 40.47  ? 194 CYS L CB  1 
ATOM   3123 S SG  . CYS B 2 201 ? 43.565 109.068 11.122  1.00 52.76  ? 194 CYS L SG  1 
ATOM   3124 N N   . GLU B 2 202 ? 43.047 112.326 13.148  1.00 33.32  ? 195 GLU L N   1 
ATOM   3125 C CA  . GLU B 2 202 ? 44.055 113.077 13.915  1.00 35.00  ? 195 GLU L CA  1 
ATOM   3126 C C   . GLU B 2 202 ? 44.990 112.153 14.662  1.00 31.23  ? 195 GLU L C   1 
ATOM   3127 O O   . GLU B 2 202 ? 44.547 111.315 15.412  1.00 32.37  ? 195 GLU L O   1 
ATOM   3128 C CB  . GLU B 2 202 ? 43.412 114.042 14.906  1.00 37.42  ? 195 GLU L CB  1 
ATOM   3129 C CG  . GLU B 2 202 ? 44.426 114.989 15.543  1.00 41.89  ? 195 GLU L CG  1 
ATOM   3130 C CD  . GLU B 2 202 ? 43.798 116.024 16.456  1.00 44.93  ? 195 GLU L CD  1 
ATOM   3131 O OE1 . GLU B 2 202 ? 42.621 115.845 16.831  1.00 47.50  ? 195 GLU L OE1 1 
ATOM   3132 O OE2 . GLU B 2 202 ? 44.483 117.013 16.800  1.00 48.69  ? 195 GLU L OE2 1 
ATOM   3133 N N   . VAL B 2 203 ? 46.287 112.377 14.507  1.00 32.20  ? 196 VAL L N   1 
ATOM   3134 C CA  . VAL B 2 203 ? 47.331 111.482 15.024  1.00 33.18  ? 196 VAL L CA  1 
ATOM   3135 C C   . VAL B 2 203 ? 48.290 112.158 16.027  1.00 31.62  ? 196 VAL L C   1 
ATOM   3136 O O   . VAL B 2 203 ? 48.939 113.157 15.704  1.00 29.78  ? 196 VAL L O   1 
ATOM   3137 C CB  . VAL B 2 203 ? 48.133 110.890 13.844  1.00 33.30  ? 196 VAL L CB  1 
ATOM   3138 C CG1 . VAL B 2 203 ? 49.418 110.204 14.315  1.00 34.70  ? 196 VAL L CG1 1 
ATOM   3139 C CG2 . VAL B 2 203 ? 47.244 109.926 13.064  1.00 32.51  ? 196 VAL L CG2 1 
ATOM   3140 N N   . THR B 2 204 ? 48.413 111.557 17.213  1.00 30.55  ? 197 THR L N   1 
ATOM   3141 C CA  . THR B 2 204 ? 49.362 112.003 18.216  1.00 29.68  ? 197 THR L CA  1 
ATOM   3142 C C   . THR B 2 204 ? 50.410 110.954 18.440  1.00 32.63  ? 197 THR L C   1 
ATOM   3143 O O   . THR B 2 204 ? 50.109 109.785 18.752  1.00 33.62  ? 197 THR L O   1 
ATOM   3144 C CB  . THR B 2 204 ? 48.694 112.293 19.548  1.00 29.35  ? 197 THR L CB  1 
ATOM   3145 O OG1 . THR B 2 204 ? 47.671 113.250 19.321  1.00 29.08  ? 197 THR L OG1 1 
ATOM   3146 C CG2 . THR B 2 204 ? 49.704 112.869 20.556  1.00 29.60  ? 197 THR L CG2 1 
ATOM   3147 N N   . HIS B 2 205 ? 51.656 111.390 18.330  1.00 32.90  ? 198 HIS L N   1 
ATOM   3148 C CA  . HIS B 2 205 ? 52.758 110.488 18.450  1.00 32.22  ? 198 HIS L CA  1 
ATOM   3149 C C   . HIS B 2 205 ? 53.987 111.265 18.887  1.00 35.72  ? 198 HIS L C   1 
ATOM   3150 O O   . HIS B 2 205 ? 54.228 112.386 18.425  1.00 33.21  ? 198 HIS L O   1 
ATOM   3151 C CB  . HIS B 2 205 ? 52.976 109.783 17.110  1.00 32.04  ? 198 HIS L CB  1 
ATOM   3152 C CG  . HIS B 2 205 ? 54.029 108.723 17.134  1.00 31.88  ? 198 HIS L CG  1 
ATOM   3153 N ND1 . HIS B 2 205 ? 55.294 108.926 16.624  1.00 32.38  ? 198 HIS L ND1 1 
ATOM   3154 C CD2 . HIS B 2 205 ? 53.995 107.438 17.559  1.00 29.83  ? 198 HIS L CD2 1 
ATOM   3155 C CE1 . HIS B 2 205 ? 56.004 107.821 16.759  1.00 31.38  ? 198 HIS L CE1 1 
ATOM   3156 N NE2 . HIS B 2 205 ? 55.240 106.902 17.323  1.00 30.52  ? 198 HIS L NE2 1 
ATOM   3157 N N   . GLN B 2 206 ? 54.707 110.641 19.816  1.00 41.67  ? 199 GLN L N   1 
ATOM   3158 C CA  . GLN B 2 206 ? 56.025 111.035 20.338  1.00 45.64  ? 199 GLN L CA  1 
ATOM   3159 C C   . GLN B 2 206 ? 56.990 111.716 19.365  1.00 46.90  ? 199 GLN L C   1 
ATOM   3160 O O   . GLN B 2 206 ? 57.557 112.765 19.677  1.00 48.38  ? 199 GLN L O   1 
ATOM   3161 C CB  . GLN B 2 206 ? 56.695 109.768 20.866  1.00 49.09  ? 199 GLN L CB  1 
ATOM   3162 C CG  . GLN B 2 206 ? 57.812 110.006 21.855  1.00 53.07  ? 199 GLN L CG  1 
ATOM   3163 C CD  . GLN B 2 206 ? 58.270 108.713 22.495  1.00 50.98  ? 199 GLN L CD  1 
ATOM   3164 O OE1 . GLN B 2 206 ? 57.494 108.045 23.167  1.00 53.43  ? 199 GLN L OE1 1 
ATOM   3165 N NE2 . GLN B 2 206 ? 59.527 108.353 22.284  1.00 53.98  ? 199 GLN L NE2 1 
ATOM   3166 N N   . GLY B 2 207 ? 57.184 111.091 18.205  1.00 45.78  ? 200 GLY L N   1 
ATOM   3167 C CA  . GLY B 2 207 ? 58.052 111.608 17.120  1.00 45.88  ? 200 GLY L CA  1 
ATOM   3168 C C   . GLY B 2 207 ? 57.610 112.844 16.339  1.00 45.29  ? 200 GLY L C   1 
ATOM   3169 O O   . GLY B 2 207 ? 58.341 113.328 15.479  1.00 47.19  ? 200 GLY L O   1 
ATOM   3170 N N   . LEU B 2 208 ? 56.416 113.345 16.643  1.00 47.44  ? 201 LEU L N   1 
ATOM   3171 C CA  . LEU B 2 208 ? 55.859 114.565 16.069  1.00 46.13  ? 201 LEU L CA  1 
ATOM   3172 C C   . LEU B 2 208 ? 55.818 115.636 17.153  1.00 48.27  ? 201 LEU L C   1 
ATOM   3173 O O   . LEU B 2 208 ? 55.630 115.309 18.324  1.00 44.49  ? 201 LEU L O   1 
ATOM   3174 C CB  . LEU B 2 208 ? 54.430 114.299 15.614  1.00 45.11  ? 201 LEU L CB  1 
ATOM   3175 C CG  . LEU B 2 208 ? 54.213 113.213 14.560  1.00 44.34  ? 201 LEU L CG  1 
ATOM   3176 C CD1 . LEU B 2 208 ? 52.820 112.620 14.708  1.00 45.06  ? 201 LEU L CD1 1 
ATOM   3177 C CD2 . LEU B 2 208 ? 54.417 113.776 13.161  1.00 43.07  ? 201 LEU L CD2 1 
ATOM   3178 N N   . SER B 2 209 ? 55.978 116.904 16.764  1.00 51.56  ? 202 SER L N   1 
ATOM   3179 C CA  . SER B 2 209 ? 56.011 118.027 17.732  1.00 52.70  ? 202 SER L CA  1 
ATOM   3180 C C   . SER B 2 209 ? 54.610 118.465 18.123  1.00 53.13  ? 202 SER L C   1 
ATOM   3181 O O   . SER B 2 209 ? 54.388 119.054 19.187  1.00 57.11  ? 202 SER L O   1 
ATOM   3182 C CB  . SER B 2 209 ? 56.838 119.229 17.223  1.00 52.57  ? 202 SER L CB  1 
ATOM   3183 O OG  . SER B 2 209 ? 56.717 119.448 15.829  1.00 54.03  ? 202 SER L OG  1 
ATOM   3184 N N   . SER B 2 210 ? 53.667 118.173 17.249  1.00 51.96  ? 203 SER L N   1 
ATOM   3185 C CA  . SER B 2 210 ? 52.269 118.462 17.498  1.00 50.62  ? 203 SER L CA  1 
ATOM   3186 C C   . SER B 2 210 ? 51.464 117.451 16.710  1.00 45.83  ? 203 SER L C   1 
ATOM   3187 O O   . SER B 2 210 ? 52.028 116.719 15.901  1.00 44.21  ? 203 SER L O   1 
ATOM   3188 C CB  . SER B 2 210 ? 51.930 119.899 17.082  1.00 52.96  ? 203 SER L CB  1 
ATOM   3189 O OG  . SER B 2 210 ? 52.255 120.134 15.722  1.00 54.41  ? 203 SER L OG  1 
ATOM   3190 N N   . PRO B 2 211 ? 50.145 117.394 16.939  1.00 43.93  ? 204 PRO L N   1 
ATOM   3191 C CA  . PRO B 2 211 ? 49.411 116.388 16.200  1.00 42.34  ? 204 PRO L CA  1 
ATOM   3192 C C   . PRO B 2 211 ? 49.212 116.731 14.734  1.00 40.12  ? 204 PRO L C   1 
ATOM   3193 O O   . PRO B 2 211 ? 49.053 117.894 14.390  1.00 38.89  ? 204 PRO L O   1 
ATOM   3194 C CB  . PRO B 2 211 ? 48.086 116.327 16.949  1.00 43.33  ? 204 PRO L CB  1 
ATOM   3195 C CG  . PRO B 2 211 ? 48.433 116.761 18.325  1.00 42.29  ? 204 PRO L CG  1 
ATOM   3196 C CD  . PRO B 2 211 ? 49.341 117.906 18.054  1.00 42.81  ? 204 PRO L CD  1 
ATOM   3197 N N   . VAL B 2 212 ? 49.250 115.711 13.888  1.00 39.84  ? 205 VAL L N   1 
ATOM   3198 C CA  . VAL B 2 212 ? 48.941 115.870 12.480  1.00 40.55  ? 205 VAL L CA  1 
ATOM   3199 C C   . VAL B 2 212 ? 47.543 115.325 12.215  1.00 38.25  ? 205 VAL L C   1 
ATOM   3200 O O   . VAL B 2 212 ? 47.154 114.259 12.725  1.00 33.24  ? 205 VAL L O   1 
ATOM   3201 C CB  . VAL B 2 212 ? 49.975 115.215 11.542  1.00 43.86  ? 205 VAL L CB  1 
ATOM   3202 C CG1 . VAL B 2 212 ? 51.369 115.395 12.107  1.00 47.84  ? 205 VAL L CG1 1 
ATOM   3203 C CG2 . VAL B 2 212 ? 49.694 113.738 11.287  1.00 45.62  ? 205 VAL L CG2 1 
ATOM   3204 N N   . THR B 2 213 ? 46.816 116.089 11.410  1.00 38.45  ? 206 THR L N   1 
ATOM   3205 C CA  . THR B 2 213 ? 45.462 115.790 10.978  1.00 38.36  ? 206 THR L CA  1 
ATOM   3206 C C   . THR B 2 213 ? 45.448 115.656 9.468   1.00 38.79  ? 206 THR L C   1 
ATOM   3207 O O   . THR B 2 213 ? 45.707 116.638 8.763   1.00 39.36  ? 206 THR L O   1 
ATOM   3208 C CB  . THR B 2 213 ? 44.500 116.917 11.351  1.00 39.42  ? 206 THR L CB  1 
ATOM   3209 O OG1 . THR B 2 213 ? 44.631 117.222 12.743  1.00 39.32  ? 206 THR L OG1 1 
ATOM   3210 C CG2 . THR B 2 213 ? 43.088 116.489 11.094  1.00 41.54  ? 206 THR L CG2 1 
ATOM   3211 N N   . LYS B 2 214 ? 45.170 114.444 8.981   1.00 39.00  ? 207 LYS L N   1 
ATOM   3212 C CA  . LYS B 2 214 ? 44.882 114.223 7.568   1.00 40.07  ? 207 LYS L CA  1 
ATOM   3213 C C   . LYS B 2 214 ? 43.396 114.117 7.427   1.00 38.20  ? 207 LYS L C   1 
ATOM   3214 O O   . LYS B 2 214 ? 42.745 113.468 8.256   1.00 38.55  ? 207 LYS L O   1 
ATOM   3215 C CB  . LYS B 2 214 ? 45.537 112.956 7.016   1.00 42.84  ? 207 LYS L CB  1 
ATOM   3216 C CG  . LYS B 2 214 ? 47.017 113.122 6.746   1.00 47.80  ? 207 LYS L CG  1 
ATOM   3217 C CD  . LYS B 2 214 ? 47.314 113.898 5.465   1.00 48.79  ? 207 LYS L CD  1 
ATOM   3218 C CE  . LYS B 2 214 ? 47.208 113.043 4.206   1.00 49.46  ? 207 LYS L CE  1 
ATOM   3219 N NZ  . LYS B 2 214 ? 48.100 113.568 3.136   1.00 50.54  ? 207 LYS L NZ  1 
ATOM   3220 N N   . SER B 2 215 ? 42.892 114.704 6.346   1.00 35.18  ? 208 SER L N   1 
ATOM   3221 C CA  . SER B 2 215 ? 41.467 114.922 6.143   1.00 39.29  ? 208 SER L CA  1 
ATOM   3222 C C   . SER B 2 215 ? 41.124 115.046 4.671   1.00 38.59  ? 208 SER L C   1 
ATOM   3223 O O   . SER B 2 215 ? 41.969 115.400 3.858   1.00 40.99  ? 208 SER L O   1 
ATOM   3224 C CB  . SER B 2 215 ? 41.034 116.226 6.823   1.00 41.40  ? 208 SER L CB  1 
ATOM   3225 O OG  . SER B 2 215 ? 41.780 117.344 6.322   1.00 41.60  ? 208 SER L OG  1 
ATOM   3226 N N   . PHE B 2 216 ? 39.876 114.747 4.342   1.00 38.44  ? 209 PHE L N   1 
ATOM   3227 C CA  . PHE B 2 216 ? 39.299 115.117 3.057   1.00 41.89  ? 209 PHE L CA  1 
ATOM   3228 C C   . PHE B 2 216 ? 37.861 115.610 3.212   1.00 49.07  ? 209 PHE L C   1 
ATOM   3229 O O   . PHE B 2 216 ? 37.144 115.304 4.192   1.00 45.48  ? 209 PHE L O   1 
ATOM   3230 C CB  . PHE B 2 216 ? 39.302 113.944 2.080   1.00 41.39  ? 209 PHE L CB  1 
ATOM   3231 C CG  . PHE B 2 216 ? 38.437 112.797 2.517   1.00 41.62  ? 209 PHE L CG  1 
ATOM   3232 C CD1 . PHE B 2 216 ? 38.919 111.861 3.437   1.00 38.12  ? 209 PHE L CD1 1 
ATOM   3233 C CD2 . PHE B 2 216 ? 37.126 112.662 2.031   1.00 40.82  ? 209 PHE L CD2 1 
ATOM   3234 C CE1 . PHE B 2 216 ? 38.119 110.804 3.854   1.00 40.48  ? 209 PHE L CE1 1 
ATOM   3235 C CE2 . PHE B 2 216 ? 36.322 111.605 2.447   1.00 41.44  ? 209 PHE L CE2 1 
ATOM   3236 C CZ  . PHE B 2 216 ? 36.821 110.666 3.359   1.00 38.74  ? 209 PHE L CZ  1 
ATOM   3237 N N   . ASN B 2 217 ? 37.448 116.343 2.191   1.00 51.30  ? 210 ASN L N   1 
ATOM   3238 C CA  . ASN B 2 217 ? 36.112 116.870 2.095   1.00 54.66  ? 210 ASN L CA  1 
ATOM   3239 C C   . ASN B 2 217 ? 35.428 116.083 0.999   1.00 56.85  ? 210 ASN L C   1 
ATOM   3240 O O   . ASN B 2 217 ? 36.053 115.779 -0.019  1.00 61.73  ? 210 ASN L O   1 
ATOM   3241 C CB  . ASN B 2 217 ? 36.179 118.356 1.732   1.00 57.74  ? 210 ASN L CB  1 
ATOM   3242 C CG  . ASN B 2 217 ? 35.040 119.158 2.336   1.00 59.92  ? 210 ASN L CG  1 
ATOM   3243 O OD1 . ASN B 2 217 ? 33.888 119.011 1.946   1.00 62.06  ? 210 ASN L OD1 1 
ATOM   3244 N ND2 . ASN B 2 217 ? 35.364 120.021 3.284   1.00 61.43  ? 210 ASN L ND2 1 
ATOM   3245 N N   . ARG B 2 218 ? 34.162 115.748 1.202   1.00 57.29  ? 211 ARG L N   1 
ATOM   3246 C CA  . ARG B 2 218 ? 33.356 115.090 0.167   1.00 57.44  ? 211 ARG L CA  1 
ATOM   3247 C C   . ARG B 2 218 ? 32.131 115.922 -0.220  1.00 53.18  ? 211 ARG L C   1 
ATOM   3248 O O   . ARG B 2 218 ? 32.061 116.430 -1.334  1.00 52.88  ? 211 ARG L O   1 
ATOM   3249 C CB  . ARG B 2 218 ? 32.939 113.698 0.621   1.00 57.74  ? 211 ARG L CB  1 
ATOM   3250 C CG  . ARG B 2 218 ? 32.147 113.676 1.919   1.00 60.63  ? 211 ARG L CG  1 
ATOM   3251 C CD  . ARG B 2 218 ? 31.352 112.401 2.042   1.00 61.79  ? 211 ARG L CD  1 
ATOM   3252 N NE  . ARG B 2 218 ? 30.413 112.316 0.935   1.00 64.12  ? 211 ARG L NE  1 
ATOM   3253 C CZ  . ARG B 2 218 ? 29.210 112.878 0.899   1.00 62.44  ? 211 ARG L CZ  1 
ATOM   3254 N NH1 . ARG B 2 218 ? 28.713 113.550 1.930   1.00 66.59  ? 211 ARG L NH1 1 
ATOM   3255 N NH2 . ARG B 2 218 ? 28.484 112.748 -0.190  1.00 66.38  ? 211 ARG L NH2 1 
ATOM   3256 N N   . ARG C 3 1   ? 51.458 63.205  45.592  1.00 53.65  ? 43  ARG A N   1 
ATOM   3257 C CA  . ARG C 3 1   ? 52.007 62.390  44.448  1.00 57.38  ? 43  ARG A CA  1 
ATOM   3258 C C   . ARG C 3 1   ? 52.441 63.255  43.257  1.00 57.85  ? 43  ARG A C   1 
ATOM   3259 O O   . ARG C 3 1   ? 52.161 62.944  42.090  1.00 57.92  ? 43  ARG A O   1 
ATOM   3260 C CB  . ARG C 3 1   ? 50.991 61.343  43.986  1.00 59.06  ? 43  ARG A CB  1 
ATOM   3261 C CG  . ARG C 3 1   ? 51.617 60.026  43.603  1.00 61.33  ? 43  ARG A CG  1 
ATOM   3262 C CD  . ARG C 3 1   ? 52.217 59.932  42.215  1.00 63.19  ? 43  ARG A CD  1 
ATOM   3263 N NE  . ARG C 3 1   ? 52.554 58.533  41.924  1.00 67.34  ? 43  ARG A NE  1 
ATOM   3264 C CZ  . ARG C 3 1   ? 52.864 58.017  40.733  1.00 72.43  ? 43  ARG A CZ  1 
ATOM   3265 N NH1 . ARG C 3 1   ? 52.901 58.768  39.628  1.00 68.40  ? 43  ARG A NH1 1 
ATOM   3266 N NH2 . ARG C 3 1   ? 53.145 56.716  40.652  1.00 77.29  ? 43  ARG A NH2 1 
ATOM   3267 N N   . ARG C 3 2   ? 53.181 64.314  43.578  1.00 58.45  ? 44  ARG A N   1 
ATOM   3268 C CA  . ARG C 3 2   ? 53.410 65.430  42.671  1.00 52.00  ? 44  ARG A CA  1 
ATOM   3269 C C   . ARG C 3 2   ? 54.300 65.077  41.471  1.00 47.30  ? 44  ARG A C   1 
ATOM   3270 O O   . ARG C 3 2   ? 55.174 64.238  41.557  1.00 42.69  ? 44  ARG A O   1 
ATOM   3271 C CB  . ARG C 3 2   ? 54.035 66.604  43.442  1.00 54.76  ? 44  ARG A CB  1 
ATOM   3272 C CG  . ARG C 3 2   ? 53.558 67.960  42.938  1.00 61.09  ? 44  ARG A CG  1 
ATOM   3273 C CD  . ARG C 3 2   ? 54.524 69.114  43.188  1.00 65.44  ? 44  ARG A CD  1 
ATOM   3274 N NE  . ARG C 3 2   ? 53.813 70.248  43.773  1.00 69.01  ? 44  ARG A NE  1 
ATOM   3275 C CZ  . ARG C 3 2   ? 53.540 70.386  45.077  1.00 79.49  ? 44  ARG A CZ  1 
ATOM   3276 N NH1 . ARG C 3 2   ? 53.930 69.480  45.986  1.00 78.81  ? 44  ARG A NH1 1 
ATOM   3277 N NH2 . ARG C 3 2   ? 52.865 71.454  45.493  1.00 88.86  ? 44  ARG A NH2 1 
ATOM   3278 N N   . PHE C 3 3   ? 54.057 65.728  40.343  1.00 44.52  ? 45  PHE A N   1 
ATOM   3279 C CA  . PHE C 3 3   ? 55.123 65.942  39.370  1.00 42.72  ? 45  PHE A CA  1 
ATOM   3280 C C   . PHE C 3 3   ? 56.027 67.082  39.863  1.00 44.61  ? 45  PHE A C   1 
ATOM   3281 O O   . PHE C 3 3   ? 55.533 68.076  40.388  1.00 42.38  ? 45  PHE A O   1 
ATOM   3282 C CB  . PHE C 3 3   ? 54.568 66.314  38.023  1.00 39.04  ? 45  PHE A CB  1 
ATOM   3283 C CG  . PHE C 3 3   ? 55.601 66.827  37.080  1.00 37.80  ? 45  PHE A CG  1 
ATOM   3284 C CD1 . PHE C 3 3   ? 56.489 65.957  36.480  1.00 39.03  ? 45  PHE A CD1 1 
ATOM   3285 C CD2 . PHE C 3 3   ? 55.706 68.188  36.800  1.00 37.43  ? 45  PHE A CD2 1 
ATOM   3286 C CE1 . PHE C 3 3   ? 57.452 66.418  35.587  1.00 37.23  ? 45  PHE A CE1 1 
ATOM   3287 C CE2 . PHE C 3 3   ? 56.662 68.656  35.910  1.00 37.39  ? 45  PHE A CE2 1 
ATOM   3288 C CZ  . PHE C 3 3   ? 57.538 67.769  35.305  1.00 37.20  ? 45  PHE A CZ  1 
ATOM   3289 N N   . TYR C 3 4   ? 57.343 66.921  39.692  1.00 45.40  ? 46  TYR A N   1 
ATOM   3290 C CA  . TYR C 3 4   ? 58.310 67.985  40.003  1.00 42.18  ? 46  TYR A CA  1 
ATOM   3291 C C   . TYR C 3 4   ? 58.970 68.464  38.732  1.00 35.82  ? 46  TYR A C   1 
ATOM   3292 O O   . TYR C 3 4   ? 59.486 67.690  37.933  1.00 33.05  ? 46  TYR A O   1 
ATOM   3293 C CB  . TYR C 3 4   ? 59.386 67.540  40.993  1.00 41.55  ? 46  TYR A CB  1 
ATOM   3294 C CG  . TYR C 3 4   ? 58.824 67.227  42.349  1.00 46.94  ? 46  TYR A CG  1 
ATOM   3295 C CD1 . TYR C 3 4   ? 58.547 68.242  43.292  1.00 48.20  ? 46  TYR A CD1 1 
ATOM   3296 C CD2 . TYR C 3 4   ? 58.539 65.915  42.691  1.00 47.66  ? 46  TYR A CD2 1 
ATOM   3297 C CE1 . TYR C 3 4   ? 58.018 67.928  44.539  1.00 51.08  ? 46  TYR A CE1 1 
ATOM   3298 C CE2 . TYR C 3 4   ? 58.009 65.590  43.920  1.00 50.22  ? 46  TYR A CE2 1 
ATOM   3299 C CZ  . TYR C 3 4   ? 57.744 66.581  44.843  1.00 54.15  ? 46  TYR A CZ  1 
ATOM   3300 O OH  . TYR C 3 4   ? 57.213 66.187  46.049  1.00 58.54  ? 46  TYR A OH  1 
ATOM   3301 N N   . GLY C 3 5   ? 58.928 69.767  38.565  1.00 32.89  ? 47  GLY A N   1 
ATOM   3302 C CA  . GLY C 3 5   ? 59.681 70.430  37.534  1.00 30.59  ? 47  GLY A CA  1 
ATOM   3303 C C   . GLY C 3 5   ? 58.842 71.336  36.675  1.00 27.49  ? 47  GLY A C   1 
ATOM   3304 O O   . GLY C 3 5   ? 57.678 71.622  37.001  1.00 25.66  ? 47  GLY A O   1 
ATOM   3305 N N   . PRO C 3 6   ? 59.464 71.836  35.591  1.00 26.41  ? 48  PRO A N   1 
ATOM   3306 C CA  . PRO C 3 6   ? 58.802 72.617  34.577  1.00 24.95  ? 48  PRO A CA  1 
ATOM   3307 C C   . PRO C 3 6   ? 57.798 71.854  33.737  1.00 24.81  ? 48  PRO A C   1 
ATOM   3308 O O   . PRO C 3 6   ? 58.056 70.723  33.328  1.00 25.85  ? 48  PRO A O   1 
ATOM   3309 C CB  . PRO C 3 6   ? 59.969 73.045  33.677  1.00 26.12  ? 48  PRO A CB  1 
ATOM   3310 C CG  . PRO C 3 6   ? 61.027 72.027  33.906  1.00 25.35  ? 48  PRO A CG  1 
ATOM   3311 C CD  . PRO C 3 6   ? 60.924 71.835  35.373  1.00 24.92  ? 48  PRO A CD  1 
ATOM   3312 N N   . VAL C 3 7   ? 56.689 72.505  33.426  1.00 24.69  ? 49  VAL A N   1 
ATOM   3313 C CA  . VAL C 3 7   ? 55.782 72.002  32.430  1.00 25.47  ? 49  VAL A CA  1 
ATOM   3314 C C   . VAL C 3 7   ? 56.484 72.002  31.062  1.00 26.41  ? 49  VAL A C   1 
ATOM   3315 O O   . VAL C 3 7   ? 56.483 71.002  30.347  1.00 26.16  ? 49  VAL A O   1 
ATOM   3316 C CB  . VAL C 3 7   ? 54.521 72.848  32.379  1.00 25.71  ? 49  VAL A CB  1 
ATOM   3317 C CG1 . VAL C 3 7   ? 53.652 72.453  31.205  1.00 25.15  ? 49  VAL A CG1 1 
ATOM   3318 C CG2 . VAL C 3 7   ? 53.732 72.701  33.681  1.00 25.85  ? 49  VAL A CG2 1 
ATOM   3319 O OXT . VAL C 3 7   ? 57.073 72.999  30.645  1.00 23.68  ? 49  VAL A OXT 1 
HETATM 3320 O O   . HOH D 4 .   ? 30.375 82.345  21.972  1.00 37.72  ? 301 HOH H O   1 
HETATM 3321 O O   . HOH D 4 .   ? 58.821 104.414 -11.659 1.00 46.73  ? 302 HOH H O   1 
HETATM 3322 O O   . HOH D 4 .   ? 53.410 92.069  -11.635 1.00 32.75  ? 303 HOH H O   1 
HETATM 3323 O O   . HOH D 4 .   ? 55.248 53.502  20.551  1.00 44.18  ? 304 HOH H O   1 
HETATM 3324 O O   . HOH D 4 .   ? 40.120 78.885  30.132  1.00 31.67  ? 305 HOH H O   1 
HETATM 3325 O O   . HOH D 4 .   ? 37.104 79.694  30.779  1.00 45.09  ? 306 HOH H O   1 
HETATM 3326 O O   . HOH D 4 .   ? 44.683 77.737  35.415  1.00 34.76  ? 307 HOH H O   1 
HETATM 3327 O O   . HOH D 4 .   ? 52.385 90.633  -2.418  1.00 48.46  ? 308 HOH H O   1 
HETATM 3328 O O   . HOH D 4 .   ? 55.804 100.307 -13.320 1.00 34.06  ? 309 HOH H O   1 
HETATM 3329 O O   . HOH D 4 .   ? 43.495 86.846  14.516  1.00 43.35  ? 310 HOH H O   1 
HETATM 3330 O O   . HOH D 4 .   ? 43.554 79.512  27.902  1.00 36.76  ? 311 HOH H O   1 
HETATM 3331 O O   . HOH D 4 .   ? 43.400 72.719  40.962  1.00 40.19  ? 312 HOH H O   1 
HETATM 3332 O O   . HOH D 4 .   ? 55.264 111.479 -5.851  1.00 48.27  ? 313 HOH H O   1 
HETATM 3333 O O   . HOH D 4 .   ? 49.538 64.036  42.670  1.00 54.42  ? 314 HOH H O   1 
HETATM 3334 O O   . HOH D 4 .   ? 39.252 74.640  27.414  1.00 28.67  ? 315 HOH H O   1 
HETATM 3335 O O   . HOH D 4 .   ? 40.538 78.356  8.403   1.00 48.27  ? 316 HOH H O   1 
HETATM 3336 O O   . HOH D 4 .   ? 48.240 51.369  27.659  1.00 47.59  ? 317 HOH H O   1 
HETATM 3337 O O   . HOH D 4 .   ? 46.594 67.068  20.455  1.00 24.93  ? 318 HOH H O   1 
HETATM 3338 O O   . HOH D 4 .   ? 58.189 60.031  18.954  1.00 52.62  ? 319 HOH H O   1 
HETATM 3339 O O   . HOH D 4 .   ? 42.533 81.512  3.169   1.00 38.43  ? 320 HOH H O   1 
HETATM 3340 O O   . HOH D 4 .   ? 44.872 88.496  10.081  1.00 34.90  ? 321 HOH H O   1 
HETATM 3341 O O   . HOH D 4 .   ? 46.351 85.829  -2.101  1.00 35.73  ? 322 HOH H O   1 
HETATM 3342 O O   . HOH D 4 .   ? 60.651 92.260  -9.264  1.00 49.15  ? 323 HOH H O   1 
HETATM 3343 O O   . HOH D 4 .   ? 39.503 103.553 -3.444  1.00 43.80  ? 324 HOH H O   1 
HETATM 3344 O O   . HOH D 4 .   ? 48.296 90.560  -7.278  1.00 30.62  ? 325 HOH H O   1 
HETATM 3345 O O   . HOH D 4 .   ? 35.184 80.272  18.478  1.00 44.63  ? 326 HOH H O   1 
HETATM 3346 O O   . HOH D 4 .   ? 29.742 77.842  23.301  1.00 24.94  ? 327 HOH H O   1 
HETATM 3347 O O   . HOH D 4 .   ? 28.718 79.104  16.754  1.00 46.86  ? 328 HOH H O   1 
HETATM 3348 O O   . HOH D 4 .   ? 47.005 62.571  28.297  1.00 27.29  ? 329 HOH H O   1 
HETATM 3349 O O   . HOH D 4 .   ? 41.219 57.618  24.570  1.00 57.46  ? 330 HOH H O   1 
HETATM 3350 O O   . HOH D 4 .   ? 45.969 72.294  14.565  1.00 36.56  ? 331 HOH H O   1 
HETATM 3351 O O   . HOH D 4 .   ? 47.981 70.302  14.979  1.00 38.48  ? 332 HOH H O   1 
HETATM 3352 O O   . HOH D 4 .   ? 68.087 70.201  30.763  1.00 31.63  ? 333 HOH H O   1 
HETATM 3353 O O   . HOH D 4 .   ? 29.955 87.462  1.579   1.00 43.93  ? 334 HOH H O   1 
HETATM 3354 O O   . HOH D 4 .   ? 62.531 58.852  22.303  1.00 50.57  ? 335 HOH H O   1 
HETATM 3355 O O   . HOH D 4 .   ? 38.751 82.645  12.835  1.00 33.07  ? 336 HOH H O   1 
HETATM 3356 O O   . HOH D 4 .   ? 61.907 64.011  37.219  1.00 46.83  ? 337 HOH H O   1 
HETATM 3357 O O   . HOH D 4 .   ? 47.025 89.272  8.570   1.00 42.66  ? 338 HOH H O   1 
HETATM 3358 O O   . HOH D 4 .   ? 47.441 84.081  6.235   1.00 49.13  ? 339 HOH H O   1 
HETATM 3359 O O   . HOH D 4 .   ? 39.359 82.173  25.707  1.00 43.58  ? 340 HOH H O   1 
HETATM 3360 O O   . HOH D 4 .   ? 38.872 97.314  8.820   1.00 43.33  ? 341 HOH H O   1 
HETATM 3361 O O   . HOH D 4 .   ? 45.875 71.525  11.484  1.00 42.24  ? 342 HOH H O   1 
HETATM 3362 O O   . HOH D 4 .   ? 45.109 86.507  7.972   1.00 33.98  ? 343 HOH H O   1 
HETATM 3363 O O   . HOH D 4 .   ? 49.368 83.958  25.854  1.00 23.99  ? 344 HOH H O   1 
HETATM 3364 O O   . HOH D 4 .   ? 54.010 93.977  7.534   1.00 45.66  ? 345 HOH H O   1 
HETATM 3365 O O   . HOH D 4 .   ? 51.138 77.822  17.842  1.00 41.78  ? 346 HOH H O   1 
HETATM 3366 O O   . HOH D 4 .   ? 48.812 53.433  32.261  1.00 47.46  ? 347 HOH H O   1 
HETATM 3367 O O   . HOH D 4 .   ? 60.172 98.366  -1.727  1.00 57.98  ? 348 HOH H O   1 
HETATM 3368 O O   . HOH D 4 .   ? 59.809 54.236  19.167  1.00 38.70  ? 349 HOH H O   1 
HETATM 3369 O O   . HOH D 4 .   ? 50.094 80.259  18.723  1.00 44.14  ? 350 HOH H O   1 
HETATM 3370 O O   . HOH D 4 .   ? 36.846 77.025  30.422  1.00 42.79  ? 351 HOH H O   1 
HETATM 3371 O O   . HOH D 4 .   ? 42.502 55.439  23.075  1.00 57.91  ? 352 HOH H O   1 
HETATM 3372 O O   . HOH D 4 .   ? 55.518 111.426 -9.913  1.00 40.42  ? 353 HOH H O   1 
HETATM 3373 O O   . HOH D 4 .   ? 45.327 80.794  -5.728  1.00 45.40  ? 354 HOH H O   1 
HETATM 3374 O O   . HOH D 4 .   ? 46.616 87.159  28.545  1.00 47.21  ? 355 HOH H O   1 
HETATM 3375 O O   . HOH D 4 .   ? 37.637 84.530  26.074  1.00 50.23  ? 356 HOH H O   1 
HETATM 3376 O O   . HOH D 4 .   ? 34.026 73.084  37.615  1.00 50.92  ? 357 HOH H O   1 
HETATM 3377 O O   . HOH D 4 .   ? 51.301 111.230 -8.929  1.00 47.20  ? 358 HOH H O   1 
HETATM 3378 O O   . HOH D 4 .   ? 33.802 73.130  32.975  1.00 45.91  ? 359 HOH H O   1 
HETATM 3379 O O   . HOH D 4 .   ? 45.491 87.310  30.916  1.00 50.86  ? 360 HOH H O   1 
HETATM 3380 O O   . HOH D 4 .   ? 21.216 68.786  19.345  1.00 39.97  ? 361 HOH H O   1 
HETATM 3381 O O   . HOH D 4 .   ? 64.403 95.794  -6.367  1.00 45.28  ? 362 HOH H O   1 
HETATM 3382 O O   . HOH E 4 .   ? 52.775 92.991  32.255  1.00 40.94  ? 301 HOH L O   1 
HETATM 3383 O O   . HOH E 4 .   ? 73.084 73.278  28.048  1.00 42.86  ? 302 HOH L O   1 
HETATM 3384 O O   . HOH E 4 .   ? 57.097 93.156  16.999  1.00 41.63  ? 303 HOH L O   1 
HETATM 3385 O O   . HOH E 4 .   ? 62.813 70.973  38.689  1.00 25.31  ? 304 HOH L O   1 
HETATM 3386 O O   . HOH E 4 .   ? 51.609 88.712  41.193  1.00 28.16  ? 305 HOH L O   1 
HETATM 3387 O O   . HOH E 4 .   ? 63.085 94.841  13.682  1.00 38.23  ? 306 HOH L O   1 
HETATM 3388 O O   . HOH E 4 .   ? 55.652 96.891  10.725  1.00 43.43  ? 307 HOH L O   1 
HETATM 3389 O O   . HOH E 4 .   ? 74.179 92.744  34.751  1.00 38.64  ? 308 HOH L O   1 
HETATM 3390 O O   . HOH E 4 .   ? 48.194 77.847  41.851  1.00 26.32  ? 309 HOH L O   1 
HETATM 3391 O O   . HOH E 4 .   ? 47.205 115.061 21.132  1.00 39.84  ? 310 HOH L O   1 
HETATM 3392 O O   . HOH E 4 .   ? 61.590 73.043  54.207  1.00 28.69  ? 311 HOH L O   1 
HETATM 3393 O O   . HOH E 4 .   ? 43.444 96.853  8.942   1.00 25.78  ? 312 HOH L O   1 
HETATM 3394 O O   . HOH E 4 .   ? 41.726 104.491 16.141  1.00 37.72  ? 313 HOH L O   1 
HETATM 3395 O O   . HOH E 4 .   ? 65.825 95.474  30.757  1.00 33.27  ? 314 HOH L O   1 
HETATM 3396 O O   . HOH E 4 .   ? 50.226 97.320  19.344  1.00 47.43  ? 315 HOH L O   1 
HETATM 3397 O O   . HOH E 4 .   ? 49.067 85.719  27.914  1.00 33.73  ? 316 HOH L O   1 
HETATM 3398 O O   . HOH E 4 .   ? 72.022 75.769  34.741  1.00 27.22  ? 317 HOH L O   1 
HETATM 3399 O O   . HOH E 4 .   ? 55.836 75.202  34.024  1.00 23.05  ? 318 HOH L O   1 
HETATM 3400 O O   . HOH E 4 .   ? 56.604 99.580  9.447   1.00 32.80  ? 319 HOH L O   1 
HETATM 3401 O O   . HOH E 4 .   ? 35.844 101.164 0.518   1.00 44.30  ? 320 HOH L O   1 
HETATM 3402 O O   . HOH E 4 .   ? 50.268 73.506  47.580  1.00 44.48  ? 321 HOH L O   1 
HETATM 3403 O O   . HOH E 4 .   ? 47.988 80.111  34.245  1.00 21.64  ? 322 HOH L O   1 
HETATM 3404 O O   . HOH E 4 .   ? 47.189 77.723  34.735  1.00 23.79  ? 323 HOH L O   1 
HETATM 3405 O O   . HOH E 4 .   ? 35.096 100.397 12.635  1.00 50.90  ? 324 HOH L O   1 
HETATM 3406 O O   . HOH E 4 .   ? 65.090 76.660  42.913  1.00 25.83  ? 325 HOH L O   1 
HETATM 3407 O O   . HOH E 4 .   ? 67.518 100.492 27.855  1.00 37.82  ? 326 HOH L O   1 
HETATM 3408 O O   . HOH E 4 .   ? 63.874 83.193  37.903  1.00 27.84  ? 327 HOH L O   1 
HETATM 3409 O O   . HOH E 4 .   ? 38.138 97.297  11.463  1.00 41.15  ? 328 HOH L O   1 
HETATM 3410 O O   . HOH E 4 .   ? 49.590 83.894  29.868  1.00 34.74  ? 329 HOH L O   1 
HETATM 3411 O O   . HOH E 4 .   ? 74.327 77.033  30.041  1.00 28.03  ? 330 HOH L O   1 
HETATM 3412 O O   . HOH E 4 .   ? 47.166 76.745  44.317  1.00 45.87  ? 331 HOH L O   1 
HETATM 3413 O O   . HOH E 4 .   ? 49.111 83.590  36.786  1.00 26.51  ? 332 HOH L O   1 
HETATM 3414 O O   . HOH E 4 .   ? 51.903 90.126  31.213  1.00 39.54  ? 333 HOH L O   1 
HETATM 3415 O O   . HOH E 4 .   ? 70.493 81.287  35.567  1.00 34.66  ? 334 HOH L O   1 
HETATM 3416 O O   . HOH E 4 .   ? 46.472 88.714  38.020  1.00 39.21  ? 335 HOH L O   1 
HETATM 3417 O O   . HOH E 4 .   ? 55.985 85.387  19.434  1.00 50.42  ? 336 HOH L O   1 
HETATM 3418 O O   . HOH E 4 .   ? 62.028 81.455  46.790  1.00 43.64  ? 337 HOH L O   1 
HETATM 3419 O O   . HOH E 4 .   ? 62.129 103.666 8.011   1.00 52.75  ? 338 HOH L O   1 
HETATM 3420 O O   . HOH E 4 .   ? 42.019 117.517 13.959  1.00 44.86  ? 339 HOH L O   1 
HETATM 3421 O O   . HOH E 4 .   ? 66.775 82.452  21.551  1.00 47.79  ? 340 HOH L O   1 
HETATM 3422 O O   . HOH E 4 .   ? 30.654 109.088 17.758  1.00 31.41  ? 341 HOH L O   1 
HETATM 3423 O O   . HOH E 4 .   ? 49.368 101.546 19.153  1.00 48.45  ? 342 HOH L O   1 
HETATM 3424 O O   . HOH E 4 .   ? 56.576 74.719  17.894  1.00 40.23  ? 343 HOH L O   1 
HETATM 3425 O O   . HOH E 4 .   ? 55.419 93.798  9.827   1.00 40.28  ? 344 HOH L O   1 
HETATM 3426 O O   . HOH E 4 .   ? 25.497 105.297 -5.511  1.00 40.50  ? 345 HOH L O   1 
HETATM 3427 O O   . HOH E 4 .   ? 63.919 81.334  19.037  1.00 48.47  ? 346 HOH L O   1 
HETATM 3428 O O   . HOH E 4 .   ? 68.552 74.695  41.599  1.00 32.46  ? 347 HOH L O   1 
HETATM 3429 O O   . HOH E 4 .   ? 46.564 116.248 3.054   1.00 51.05  ? 348 HOH L O   1 
HETATM 3430 O O   . HOH E 4 .   ? 62.454 75.445  51.974  1.00 28.28  ? 349 HOH L O   1 
HETATM 3431 O O   . HOH E 4 .   ? 39.486 109.187 21.112  1.00 45.24  ? 350 HOH L O   1 
HETATM 3432 O O   . HOH E 4 .   ? 29.048 114.439 12.960  1.00 46.61  ? 351 HOH L O   1 
HETATM 3433 O O   . HOH E 4 .   ? 42.189 75.734  41.516  1.00 37.96  ? 352 HOH L O   1 
HETATM 3434 O O   . HOH E 4 .   ? 51.316 88.760  25.738  1.00 38.70  ? 353 HOH L O   1 
HETATM 3435 O O   . HOH E 4 .   ? 61.328 110.897 11.828  1.00 44.66  ? 354 HOH L O   1 
HETATM 3436 O O   . HOH E 4 .   ? 65.826 76.128  50.575  1.00 48.76  ? 355 HOH L O   1 
HETATM 3437 O O   . HOH E 4 .   ? 52.613 91.303  25.396  1.00 37.94  ? 356 HOH L O   1 
HETATM 3438 O O   . HOH E 4 .   ? 60.700 96.204  35.363  1.00 47.47  ? 357 HOH L O   1 
HETATM 3439 O O   . HOH E 4 .   ? 64.032 94.775  -1.180  1.00 53.80  ? 358 HOH L O   1 
HETATM 3440 O O   . HOH E 4 .   ? 45.818 98.282  19.194  1.00 47.62  ? 359 HOH L O   1 
HETATM 3441 O O   . HOH E 4 .   ? 66.152 80.342  47.202  1.00 41.12  ? 360 HOH L O   1 
HETATM 3442 O O   . HOH E 4 .   ? 29.181 118.740 -4.432  1.00 35.23  ? 361 HOH L O   1 
HETATM 3443 O O   . HOH F 4 .   ? 58.143 70.077  28.542  1.00 36.88  ? 101 HOH A O   1 
HETATM 3444 O O   . HOH F 4 .   ? 57.304 71.181  40.397  1.00 38.59  ? 102 HOH A O   1 
HETATM 3445 O O   . HOH F 4 .   ? 57.854 63.395  46.305  1.00 43.32  ? 103 HOH A O   1 
HETATM 3446 O O   . HOH F 4 .   ? 59.616 64.551  38.137  1.00 27.23  ? 104 HOH A O   1 
HETATM 3447 O O   . HOH F 4 .   ? 52.259 65.964  47.578  1.00 46.33  ? 105 HOH A O   1 
# 
