data_8XQC
# 
_entry.id   8XQC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XQC         pdb_00008xqc 10.2210/pdb8xqc/pdb 
WWPDB D_1300043843 ?            ?                   
EMDB  EMD-38573    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XQC 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog' 
_pdbx_database_related.db_id          EMD-38573 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aritak@yokohama-cu.ac.jp 
_pdbx_contact_author.name_first         Kyohei 
_pdbx_contact_author.name_last          Arita 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9762-8405 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kikuchi, A.' 1 0000-0002-5112-0868 
'Hayashi, G.' 2 0000-0001-6853-2706 
'Kori, S.'    3 0000-0002-3436-8132 
'Arita, K.'   4 0000-0002-9762-8405 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Activation of DNMT1 by Chemically Synthesized Dual monoubiquitinated PAF15 Protein' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hayashi, G.'   1 0000-0001-6853-2706 
primary 'Takahashi, Y.' 2 ?                   
primary 'Kikuchi, A.'   3 0000-0002-5112-0868 
primary 'Kori, S.'      4 0000-0002-3436-8132 
primary 'Arita, K.'     5 0000-0002-9762-8405 
primary 'Murakami, H.'  6 0000-0003-2089-9263 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'DNA (cytosine-5)-methyltransferase 1'                   143559.531 1 2.1.1.37 ? ? ? 
2 polymer     syn 
;DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3')
;
3725.469   1 ?        ? ? ? 
3 polymer     syn 
;DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3')
;
3679.464   1 ?        ? ? ? 
4 non-polymer syn S-ADENOSYL-L-HOMOCYSTEINE                                384.411    1 ?        ? ? ? 
5 non-polymer syn 'ZINC ION'                                               65.409     2 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Dnmt1,CXXC-type zinc finger protein 9,DNA methyltransferase HsaI,DNA MTase HsaI,M.HsaI,MCMT' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no  
;GPPTTPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTG
LIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEK
IYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLI
KLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECG
KCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKS
YYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQL
SYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQK
EIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNL
DAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYG
EDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVF
SGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPP
CQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYG
VAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALE
ISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNG
RSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQH
RVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
;
;GPPTTPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTG
LIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEK
IYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLI
KLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECG
KCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKS
YYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQL
SYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQK
EIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNL
DAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYG
EDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVF
SGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPP
CQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYG
VAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALE
ISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNG
RSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQH
RVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
;
A ? 
2 polydeoxyribonucleotide no yes '(DA)(DC)(DT)(DT)(DA)(5CM)(DG)(DG)(DA)(DA)(DG)(DG)' ACTTACGGAAGG B ? 
3 polydeoxyribonucleotide no yes '(DC)(DC)(DT)(DT)(DC)(EIX)(DG)(DT)(DA)(DA)(DG)(DT)' CCTTCCGTAAGT C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 S-ADENOSYL-L-HOMOCYSTEINE SAH 
5 'ZINC ION'                ZN  
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1    GLY n 
1 2    PRO n 
1 3    PRO n 
1 4    THR n 
1 5    THR n 
1 6    PRO n 
1 7    LYS n 
1 8    CYS n 
1 9    ILE n 
1 10   GLN n 
1 11   CYS n 
1 12   GLY n 
1 13   GLN n 
1 14   TYR n 
1 15   LEU n 
1 16   ASP n 
1 17   ASP n 
1 18   PRO n 
1 19   ASP n 
1 20   LEU n 
1 21   LYS n 
1 22   TYR n 
1 23   GLY n 
1 24   GLN n 
1 25   HIS n 
1 26   PRO n 
1 27   PRO n 
1 28   ASP n 
1 29   ALA n 
1 30   VAL n 
1 31   ASP n 
1 32   GLU n 
1 33   PRO n 
1 34   GLN n 
1 35   MET n 
1 36   LEU n 
1 37   THR n 
1 38   ASN n 
1 39   GLU n 
1 40   LYS n 
1 41   LEU n 
1 42   SER n 
1 43   ILE n 
1 44   PHE n 
1 45   ASP n 
1 46   ALA n 
1 47   ASN n 
1 48   GLU n 
1 49   SER n 
1 50   GLY n 
1 51   PHE n 
1 52   GLU n 
1 53   SER n 
1 54   TYR n 
1 55   GLU n 
1 56   ALA n 
1 57   LEU n 
1 58   PRO n 
1 59   GLN n 
1 60   HIS n 
1 61   LYS n 
1 62   LEU n 
1 63   THR n 
1 64   CYS n 
1 65   PHE n 
1 66   SER n 
1 67   VAL n 
1 68   TYR n 
1 69   CYS n 
1 70   LYS n 
1 71   HIS n 
1 72   GLY n 
1 73   HIS n 
1 74   LEU n 
1 75   CYS n 
1 76   PRO n 
1 77   ILE n 
1 78   ASP n 
1 79   THR n 
1 80   GLY n 
1 81   LEU n 
1 82   ILE n 
1 83   GLU n 
1 84   LYS n 
1 85   ASN n 
1 86   ILE n 
1 87   GLU n 
1 88   LEU n 
1 89   PHE n 
1 90   PHE n 
1 91   SER n 
1 92   GLY n 
1 93   SER n 
1 94   ALA n 
1 95   LYS n 
1 96   PRO n 
1 97   ILE n 
1 98   TYR n 
1 99   ASP n 
1 100  ASP n 
1 101  ASP n 
1 102  PRO n 
1 103  SER n 
1 104  LEU n 
1 105  GLU n 
1 106  GLY n 
1 107  GLY n 
1 108  VAL n 
1 109  ASN n 
1 110  GLY n 
1 111  LYS n 
1 112  ASN n 
1 113  LEU n 
1 114  GLY n 
1 115  PRO n 
1 116  ILE n 
1 117  ASN n 
1 118  GLU n 
1 119  TRP n 
1 120  TRP n 
1 121  ILE n 
1 122  THR n 
1 123  GLY n 
1 124  PHE n 
1 125  ASP n 
1 126  GLY n 
1 127  GLY n 
1 128  GLU n 
1 129  LYS n 
1 130  ALA n 
1 131  LEU n 
1 132  ILE n 
1 133  GLY n 
1 134  PHE n 
1 135  SER n 
1 136  THR n 
1 137  SER n 
1 138  PHE n 
1 139  ALA n 
1 140  GLU n 
1 141  TYR n 
1 142  ILE n 
1 143  LEU n 
1 144  MET n 
1 145  ASP n 
1 146  PRO n 
1 147  SER n 
1 148  PRO n 
1 149  GLU n 
1 150  TYR n 
1 151  ALA n 
1 152  PRO n 
1 153  ILE n 
1 154  PHE n 
1 155  GLY n 
1 156  LEU n 
1 157  MET n 
1 158  GLN n 
1 159  GLU n 
1 160  LYS n 
1 161  ILE n 
1 162  TYR n 
1 163  ILE n 
1 164  SER n 
1 165  LYS n 
1 166  ILE n 
1 167  VAL n 
1 168  VAL n 
1 169  GLU n 
1 170  PHE n 
1 171  LEU n 
1 172  GLN n 
1 173  SER n 
1 174  ASN n 
1 175  SER n 
1 176  ASP n 
1 177  SER n 
1 178  THR n 
1 179  TYR n 
1 180  GLU n 
1 181  ASP n 
1 182  LEU n 
1 183  ILE n 
1 184  ASN n 
1 185  LYS n 
1 186  ILE n 
1 187  GLU n 
1 188  THR n 
1 189  THR n 
1 190  VAL n 
1 191  PRO n 
1 192  PRO n 
1 193  SER n 
1 194  GLY n 
1 195  LEU n 
1 196  ASN n 
1 197  LEU n 
1 198  ASN n 
1 199  ARG n 
1 200  PHE n 
1 201  THR n 
1 202  GLU n 
1 203  ASP n 
1 204  SER n 
1 205  LEU n 
1 206  LEU n 
1 207  ARG n 
1 208  HIS n 
1 209  ALA n 
1 210  GLN n 
1 211  PHE n 
1 212  VAL n 
1 213  VAL n 
1 214  GLU n 
1 215  GLN n 
1 216  VAL n 
1 217  GLU n 
1 218  SER n 
1 219  TYR n 
1 220  ASP n 
1 221  GLU n 
1 222  ALA n 
1 223  GLY n 
1 224  ASP n 
1 225  SER n 
1 226  ASP n 
1 227  GLU n 
1 228  GLN n 
1 229  PRO n 
1 230  ILE n 
1 231  PHE n 
1 232  LEU n 
1 233  THR n 
1 234  PRO n 
1 235  CYS n 
1 236  MET n 
1 237  ARG n 
1 238  ASP n 
1 239  LEU n 
1 240  ILE n 
1 241  LYS n 
1 242  LEU n 
1 243  ALA n 
1 244  GLY n 
1 245  VAL n 
1 246  THR n 
1 247  LEU n 
1 248  GLY n 
1 249  GLN n 
1 250  ARG n 
1 251  ARG n 
1 252  ALA n 
1 253  GLN n 
1 254  ALA n 
1 255  ARG n 
1 256  ARG n 
1 257  GLN n 
1 258  THR n 
1 259  ILE n 
1 260  ARG n 
1 261  HIS n 
1 262  SER n 
1 263  THR n 
1 264  ARG n 
1 265  GLU n 
1 266  LYS n 
1 267  ASP n 
1 268  ARG n 
1 269  GLY n 
1 270  PRO n 
1 271  THR n 
1 272  LYS n 
1 273  ALA n 
1 274  THR n 
1 275  THR n 
1 276  THR n 
1 277  LYS n 
1 278  LEU n 
1 279  VAL n 
1 280  TYR n 
1 281  GLN n 
1 282  ILE n 
1 283  PHE n 
1 284  ASP n 
1 285  THR n 
1 286  PHE n 
1 287  PHE n 
1 288  ALA n 
1 289  GLU n 
1 290  GLN n 
1 291  ILE n 
1 292  GLU n 
1 293  LYS n 
1 294  ASP n 
1 295  ASP n 
1 296  ARG n 
1 297  GLU n 
1 298  ASP n 
1 299  LYS n 
1 300  GLU n 
1 301  ASN n 
1 302  ALA n 
1 303  PHE n 
1 304  LYS n 
1 305  ARG n 
1 306  ARG n 
1 307  ARG n 
1 308  CYS n 
1 309  GLY n 
1 310  VAL n 
1 311  CYS n 
1 312  GLU n 
1 313  VAL n 
1 314  CYS n 
1 315  GLN n 
1 316  GLN n 
1 317  PRO n 
1 318  GLU n 
1 319  CYS n 
1 320  GLY n 
1 321  LYS n 
1 322  CYS n 
1 323  LYS n 
1 324  ALA n 
1 325  CYS n 
1 326  LYS n 
1 327  ASP n 
1 328  MET n 
1 329  VAL n 
1 330  LYS n 
1 331  PHE n 
1 332  GLY n 
1 333  GLY n 
1 334  SER n 
1 335  GLY n 
1 336  ARG n 
1 337  SER n 
1 338  LYS n 
1 339  GLN n 
1 340  ALA n 
1 341  CYS n 
1 342  GLN n 
1 343  GLU n 
1 344  ARG n 
1 345  ARG n 
1 346  CYS n 
1 347  PRO n 
1 348  ASN n 
1 349  MET n 
1 350  ALA n 
1 351  MET n 
1 352  LYS n 
1 353  GLU n 
1 354  ALA n 
1 355  ASP n 
1 356  ASP n 
1 357  ASP n 
1 358  GLU n 
1 359  GLU n 
1 360  VAL n 
1 361  ASP n 
1 362  ASP n 
1 363  ASN n 
1 364  ILE n 
1 365  PRO n 
1 366  GLU n 
1 367  MET n 
1 368  PRO n 
1 369  SER n 
1 370  PRO n 
1 371  LYS n 
1 372  LYS n 
1 373  MET n 
1 374  HIS n 
1 375  GLN n 
1 376  GLY n 
1 377  LYS n 
1 378  LYS n 
1 379  LYS n 
1 380  LYS n 
1 381  GLN n 
1 382  ASN n 
1 383  LYS n 
1 384  ASN n 
1 385  ARG n 
1 386  ILE n 
1 387  SER n 
1 388  TRP n 
1 389  VAL n 
1 390  GLY n 
1 391  GLU n 
1 392  ALA n 
1 393  VAL n 
1 394  LYS n 
1 395  THR n 
1 396  ASP n 
1 397  GLY n 
1 398  LYS n 
1 399  LYS n 
1 400  SER n 
1 401  TYR n 
1 402  TYR n 
1 403  LYS n 
1 404  LYS n 
1 405  VAL n 
1 406  CYS n 
1 407  ILE n 
1 408  ASP n 
1 409  ALA n 
1 410  GLU n 
1 411  THR n 
1 412  LEU n 
1 413  GLU n 
1 414  VAL n 
1 415  GLY n 
1 416  ASP n 
1 417  CYS n 
1 418  VAL n 
1 419  SER n 
1 420  VAL n 
1 421  ILE n 
1 422  PRO n 
1 423  ASP n 
1 424  ASP n 
1 425  SER n 
1 426  SER n 
1 427  LYS n 
1 428  PRO n 
1 429  LEU n 
1 430  TYR n 
1 431  LEU n 
1 432  ALA n 
1 433  ARG n 
1 434  VAL n 
1 435  THR n 
1 436  ALA n 
1 437  LEU n 
1 438  TRP n 
1 439  GLU n 
1 440  ASP n 
1 441  SER n 
1 442  SER n 
1 443  ASN n 
1 444  GLY n 
1 445  GLN n 
1 446  MET n 
1 447  PHE n 
1 448  HIS n 
1 449  ALA n 
1 450  HIS n 
1 451  TRP n 
1 452  PHE n 
1 453  CYS n 
1 454  ALA n 
1 455  GLY n 
1 456  THR n 
1 457  ASP n 
1 458  THR n 
1 459  VAL n 
1 460  LEU n 
1 461  GLY n 
1 462  ALA n 
1 463  THR n 
1 464  SER n 
1 465  ASP n 
1 466  PRO n 
1 467  LEU n 
1 468  GLU n 
1 469  LEU n 
1 470  PHE n 
1 471  LEU n 
1 472  VAL n 
1 473  ASP n 
1 474  GLU n 
1 475  CYS n 
1 476  GLU n 
1 477  ASP n 
1 478  MET n 
1 479  GLN n 
1 480  LEU n 
1 481  SER n 
1 482  TYR n 
1 483  ILE n 
1 484  HIS n 
1 485  SER n 
1 486  LYS n 
1 487  VAL n 
1 488  LYS n 
1 489  VAL n 
1 490  ILE n 
1 491  TYR n 
1 492  LYS n 
1 493  ALA n 
1 494  PRO n 
1 495  SER n 
1 496  GLU n 
1 497  ASN n 
1 498  TRP n 
1 499  ALA n 
1 500  MET n 
1 501  GLU n 
1 502  GLY n 
1 503  GLY n 
1 504  MET n 
1 505  ASP n 
1 506  PRO n 
1 507  GLU n 
1 508  SER n 
1 509  LEU n 
1 510  LEU n 
1 511  GLU n 
1 512  GLY n 
1 513  ASP n 
1 514  ASP n 
1 515  GLY n 
1 516  LYS n 
1 517  THR n 
1 518  TYR n 
1 519  PHE n 
1 520  TYR n 
1 521  GLN n 
1 522  LEU n 
1 523  TRP n 
1 524  TYR n 
1 525  ASP n 
1 526  GLN n 
1 527  ASP n 
1 528  TYR n 
1 529  ALA n 
1 530  ARG n 
1 531  PHE n 
1 532  GLU n 
1 533  SER n 
1 534  PRO n 
1 535  PRO n 
1 536  LYS n 
1 537  THR n 
1 538  GLN n 
1 539  PRO n 
1 540  THR n 
1 541  GLU n 
1 542  ASP n 
1 543  ASN n 
1 544  LYS n 
1 545  PHE n 
1 546  LYS n 
1 547  PHE n 
1 548  CYS n 
1 549  VAL n 
1 550  SER n 
1 551  CYS n 
1 552  ALA n 
1 553  ARG n 
1 554  LEU n 
1 555  ALA n 
1 556  GLU n 
1 557  MET n 
1 558  ARG n 
1 559  GLN n 
1 560  LYS n 
1 561  GLU n 
1 562  ILE n 
1 563  PRO n 
1 564  ARG n 
1 565  VAL n 
1 566  LEU n 
1 567  GLU n 
1 568  GLN n 
1 569  LEU n 
1 570  GLU n 
1 571  ASP n 
1 572  LEU n 
1 573  ASP n 
1 574  SER n 
1 575  ARG n 
1 576  VAL n 
1 577  LEU n 
1 578  TYR n 
1 579  TYR n 
1 580  SER n 
1 581  ALA n 
1 582  THR n 
1 583  LYS n 
1 584  ASN n 
1 585  GLY n 
1 586  ILE n 
1 587  LEU n 
1 588  TYR n 
1 589  ARG n 
1 590  VAL n 
1 591  GLY n 
1 592  ASP n 
1 593  GLY n 
1 594  VAL n 
1 595  TYR n 
1 596  LEU n 
1 597  PRO n 
1 598  PRO n 
1 599  GLU n 
1 600  ALA n 
1 601  PHE n 
1 602  THR n 
1 603  PHE n 
1 604  ASN n 
1 605  ILE n 
1 606  LYS n 
1 607  LEU n 
1 608  SER n 
1 609  SER n 
1 610  PRO n 
1 611  VAL n 
1 612  LYS n 
1 613  ARG n 
1 614  PRO n 
1 615  ARG n 
1 616  LYS n 
1 617  GLU n 
1 618  PRO n 
1 619  VAL n 
1 620  ASP n 
1 621  GLU n 
1 622  ASP n 
1 623  LEU n 
1 624  TYR n 
1 625  PRO n 
1 626  GLU n 
1 627  HIS n 
1 628  TYR n 
1 629  ARG n 
1 630  LYS n 
1 631  TYR n 
1 632  SER n 
1 633  ASP n 
1 634  TYR n 
1 635  ILE n 
1 636  LYS n 
1 637  GLY n 
1 638  SER n 
1 639  ASN n 
1 640  LEU n 
1 641  ASP n 
1 642  ALA n 
1 643  PRO n 
1 644  GLU n 
1 645  PRO n 
1 646  TYR n 
1 647  ARG n 
1 648  ILE n 
1 649  GLY n 
1 650  ARG n 
1 651  ILE n 
1 652  LYS n 
1 653  GLU n 
1 654  ILE n 
1 655  PHE n 
1 656  CYS n 
1 657  PRO n 
1 658  LYS n 
1 659  LYS n 
1 660  SER n 
1 661  ASN n 
1 662  GLY n 
1 663  ARG n 
1 664  PRO n 
1 665  ASN n 
1 666  GLU n 
1 667  THR n 
1 668  ASP n 
1 669  ILE n 
1 670  LYS n 
1 671  ILE n 
1 672  ARG n 
1 673  VAL n 
1 674  ASN n 
1 675  LYS n 
1 676  PHE n 
1 677  TYR n 
1 678  ARG n 
1 679  PRO n 
1 680  GLU n 
1 681  ASN n 
1 682  THR n 
1 683  HIS n 
1 684  LYS n 
1 685  SER n 
1 686  THR n 
1 687  PRO n 
1 688  ALA n 
1 689  SER n 
1 690  TYR n 
1 691  HIS n 
1 692  ALA n 
1 693  ASP n 
1 694  ILE n 
1 695  ASN n 
1 696  LEU n 
1 697  LEU n 
1 698  TYR n 
1 699  TRP n 
1 700  SER n 
1 701  ASP n 
1 702  GLU n 
1 703  GLU n 
1 704  ALA n 
1 705  VAL n 
1 706  VAL n 
1 707  ASP n 
1 708  PHE n 
1 709  LYS n 
1 710  ALA n 
1 711  VAL n 
1 712  GLN n 
1 713  GLY n 
1 714  ARG n 
1 715  CYS n 
1 716  THR n 
1 717  VAL n 
1 718  GLU n 
1 719  TYR n 
1 720  GLY n 
1 721  GLU n 
1 722  ASP n 
1 723  LEU n 
1 724  PRO n 
1 725  GLU n 
1 726  CYS n 
1 727  VAL n 
1 728  GLN n 
1 729  VAL n 
1 730  TYR n 
1 731  SER n 
1 732  MET n 
1 733  GLY n 
1 734  GLY n 
1 735  PRO n 
1 736  ASN n 
1 737  ARG n 
1 738  PHE n 
1 739  TYR n 
1 740  PHE n 
1 741  LEU n 
1 742  GLU n 
1 743  ALA n 
1 744  TYR n 
1 745  ASN n 
1 746  ALA n 
1 747  LYS n 
1 748  SER n 
1 749  LYS n 
1 750  SER n 
1 751  PHE n 
1 752  GLU n 
1 753  ASP n 
1 754  PRO n 
1 755  PRO n 
1 756  ASN n 
1 757  HIS n 
1 758  ALA n 
1 759  ARG n 
1 760  SER n 
1 761  PRO n 
1 762  GLY n 
1 763  ASN n 
1 764  LYS n 
1 765  GLY n 
1 766  LYS n 
1 767  GLY n 
1 768  LYS n 
1 769  GLY n 
1 770  LYS n 
1 771  GLY n 
1 772  LYS n 
1 773  GLY n 
1 774  LYS n 
1 775  PRO n 
1 776  LYS n 
1 777  SER n 
1 778  GLN n 
1 779  ALA n 
1 780  CYS n 
1 781  GLU n 
1 782  PRO n 
1 783  SER n 
1 784  GLU n 
1 785  PRO n 
1 786  GLU n 
1 787  ILE n 
1 788  GLU n 
1 789  ILE n 
1 790  LYS n 
1 791  LEU n 
1 792  PRO n 
1 793  LYS n 
1 794  LEU n 
1 795  ARG n 
1 796  THR n 
1 797  LEU n 
1 798  ASP n 
1 799  VAL n 
1 800  PHE n 
1 801  SER n 
1 802  GLY n 
1 803  CYS n 
1 804  GLY n 
1 805  GLY n 
1 806  LEU n 
1 807  SER n 
1 808  GLU n 
1 809  GLY n 
1 810  PHE n 
1 811  HIS n 
1 812  GLN n 
1 813  ALA n 
1 814  GLY n 
1 815  ILE n 
1 816  SER n 
1 817  ASP n 
1 818  THR n 
1 819  LEU n 
1 820  TRP n 
1 821  ALA n 
1 822  ILE n 
1 823  GLU n 
1 824  MET n 
1 825  TRP n 
1 826  ASP n 
1 827  PRO n 
1 828  ALA n 
1 829  ALA n 
1 830  GLN n 
1 831  ALA n 
1 832  PHE n 
1 833  ARG n 
1 834  LEU n 
1 835  ASN n 
1 836  ASN n 
1 837  PRO n 
1 838  GLY n 
1 839  SER n 
1 840  THR n 
1 841  VAL n 
1 842  PHE n 
1 843  THR n 
1 844  GLU n 
1 845  ASP n 
1 846  CYS n 
1 847  ASN n 
1 848  ILE n 
1 849  LEU n 
1 850  LEU n 
1 851  LYS n 
1 852  LEU n 
1 853  VAL n 
1 854  MET n 
1 855  ALA n 
1 856  GLY n 
1 857  GLU n 
1 858  THR n 
1 859  THR n 
1 860  ASN n 
1 861  SER n 
1 862  ARG n 
1 863  GLY n 
1 864  GLN n 
1 865  ARG n 
1 866  LEU n 
1 867  PRO n 
1 868  GLN n 
1 869  LYS n 
1 870  GLY n 
1 871  ASP n 
1 872  VAL n 
1 873  GLU n 
1 874  MET n 
1 875  LEU n 
1 876  CYS n 
1 877  GLY n 
1 878  GLY n 
1 879  PRO n 
1 880  PRO n 
1 881  CYS n 
1 882  GLN n 
1 883  GLY n 
1 884  PHE n 
1 885  SER n 
1 886  GLY n 
1 887  MET n 
1 888  ASN n 
1 889  ARG n 
1 890  PHE n 
1 891  ASN n 
1 892  SER n 
1 893  ARG n 
1 894  THR n 
1 895  TYR n 
1 896  SER n 
1 897  LYS n 
1 898  PHE n 
1 899  LYS n 
1 900  ASN n 
1 901  SER n 
1 902  LEU n 
1 903  VAL n 
1 904  VAL n 
1 905  SER n 
1 906  PHE n 
1 907  LEU n 
1 908  SER n 
1 909  TYR n 
1 910  CYS n 
1 911  ASP n 
1 912  TYR n 
1 913  TYR n 
1 914  ARG n 
1 915  PRO n 
1 916  ARG n 
1 917  PHE n 
1 918  PHE n 
1 919  LEU n 
1 920  LEU n 
1 921  GLU n 
1 922  ASN n 
1 923  VAL n 
1 924  ARG n 
1 925  ASN n 
1 926  PHE n 
1 927  VAL n 
1 928  SER n 
1 929  PHE n 
1 930  LYS n 
1 931  ARG n 
1 932  SER n 
1 933  MET n 
1 934  VAL n 
1 935  LEU n 
1 936  LYS n 
1 937  LEU n 
1 938  THR n 
1 939  LEU n 
1 940  ARG n 
1 941  CYS n 
1 942  LEU n 
1 943  VAL n 
1 944  ARG n 
1 945  MET n 
1 946  GLY n 
1 947  TYR n 
1 948  GLN n 
1 949  CYS n 
1 950  THR n 
1 951  PHE n 
1 952  GLY n 
1 953  VAL n 
1 954  LEU n 
1 955  GLN n 
1 956  ALA n 
1 957  GLY n 
1 958  GLN n 
1 959  TYR n 
1 960  GLY n 
1 961  VAL n 
1 962  ALA n 
1 963  GLN n 
1 964  THR n 
1 965  ARG n 
1 966  ARG n 
1 967  ARG n 
1 968  ALA n 
1 969  ILE n 
1 970  ILE n 
1 971  LEU n 
1 972  ALA n 
1 973  ALA n 
1 974  ALA n 
1 975  PRO n 
1 976  GLY n 
1 977  GLU n 
1 978  LYS n 
1 979  LEU n 
1 980  PRO n 
1 981  LEU n 
1 982  PHE n 
1 983  PRO n 
1 984  GLU n 
1 985  PRO n 
1 986  LEU n 
1 987  HIS n 
1 988  VAL n 
1 989  PHE n 
1 990  ALA n 
1 991  PRO n 
1 992  ARG n 
1 993  ALA n 
1 994  CYS n 
1 995  GLN n 
1 996  LEU n 
1 997  SER n 
1 998  VAL n 
1 999  VAL n 
1 1000 VAL n 
1 1001 ASP n 
1 1002 ASP n 
1 1003 LYS n 
1 1004 LYS n 
1 1005 PHE n 
1 1006 VAL n 
1 1007 SER n 
1 1008 ASN n 
1 1009 ILE n 
1 1010 THR n 
1 1011 ARG n 
1 1012 LEU n 
1 1013 SER n 
1 1014 SER n 
1 1015 GLY n 
1 1016 PRO n 
1 1017 PHE n 
1 1018 ARG n 
1 1019 THR n 
1 1020 ILE n 
1 1021 THR n 
1 1022 VAL n 
1 1023 ARG n 
1 1024 ASP n 
1 1025 THR n 
1 1026 MET n 
1 1027 SER n 
1 1028 ASP n 
1 1029 LEU n 
1 1030 PRO n 
1 1031 GLU n 
1 1032 VAL n 
1 1033 ARG n 
1 1034 ASN n 
1 1035 GLY n 
1 1036 ALA n 
1 1037 SER n 
1 1038 ALA n 
1 1039 LEU n 
1 1040 GLU n 
1 1041 ILE n 
1 1042 SER n 
1 1043 TYR n 
1 1044 ASN n 
1 1045 GLY n 
1 1046 GLU n 
1 1047 PRO n 
1 1048 GLN n 
1 1049 SER n 
1 1050 TRP n 
1 1051 PHE n 
1 1052 GLN n 
1 1053 ARG n 
1 1054 GLN n 
1 1055 LEU n 
1 1056 ARG n 
1 1057 GLY n 
1 1058 ALA n 
1 1059 GLN n 
1 1060 TYR n 
1 1061 GLN n 
1 1062 PRO n 
1 1063 ILE n 
1 1064 LEU n 
1 1065 ARG n 
1 1066 ASP n 
1 1067 HIS n 
1 1068 ILE n 
1 1069 CYS n 
1 1070 LYS n 
1 1071 ASP n 
1 1072 MET n 
1 1073 SER n 
1 1074 ALA n 
1 1075 LEU n 
1 1076 VAL n 
1 1077 ALA n 
1 1078 ALA n 
1 1079 ARG n 
1 1080 MET n 
1 1081 ARG n 
1 1082 HIS n 
1 1083 ILE n 
1 1084 PRO n 
1 1085 LEU n 
1 1086 ALA n 
1 1087 PRO n 
1 1088 GLY n 
1 1089 SER n 
1 1090 ASP n 
1 1091 TRP n 
1 1092 ARG n 
1 1093 ASP n 
1 1094 LEU n 
1 1095 PRO n 
1 1096 ASN n 
1 1097 ILE n 
1 1098 GLU n 
1 1099 VAL n 
1 1100 ARG n 
1 1101 LEU n 
1 1102 SER n 
1 1103 ASP n 
1 1104 GLY n 
1 1105 THR n 
1 1106 MET n 
1 1107 ALA n 
1 1108 ARG n 
1 1109 LYS n 
1 1110 LEU n 
1 1111 ARG n 
1 1112 TYR n 
1 1113 THR n 
1 1114 HIS n 
1 1115 HIS n 
1 1116 ASP n 
1 1117 ARG n 
1 1118 LYS n 
1 1119 ASN n 
1 1120 GLY n 
1 1121 ARG n 
1 1122 SER n 
1 1123 SER n 
1 1124 SER n 
1 1125 GLY n 
1 1126 ALA n 
1 1127 LEU n 
1 1128 ARG n 
1 1129 GLY n 
1 1130 VAL n 
1 1131 CYS n 
1 1132 SER n 
1 1133 CYS n 
1 1134 VAL n 
1 1135 GLU n 
1 1136 ALA n 
1 1137 GLY n 
1 1138 LYS n 
1 1139 ALA n 
1 1140 CYS n 
1 1141 ASP n 
1 1142 PRO n 
1 1143 ALA n 
1 1144 ALA n 
1 1145 ARG n 
1 1146 GLN n 
1 1147 PHE n 
1 1148 ASN n 
1 1149 THR n 
1 1150 LEU n 
1 1151 ILE n 
1 1152 PRO n 
1 1153 TRP n 
1 1154 CYS n 
1 1155 LEU n 
1 1156 PRO n 
1 1157 HIS n 
1 1158 THR n 
1 1159 GLY n 
1 1160 ASN n 
1 1161 ARG n 
1 1162 HIS n 
1 1163 ASN n 
1 1164 HIS n 
1 1165 TRP n 
1 1166 ALA n 
1 1167 GLY n 
1 1168 LEU n 
1 1169 TYR n 
1 1170 GLY n 
1 1171 ARG n 
1 1172 LEU n 
1 1173 GLU n 
1 1174 TRP n 
1 1175 ASP n 
1 1176 GLY n 
1 1177 PHE n 
1 1178 PHE n 
1 1179 SER n 
1 1180 THR n 
1 1181 THR n 
1 1182 VAL n 
1 1183 THR n 
1 1184 ASN n 
1 1185 PRO n 
1 1186 GLU n 
1 1187 PRO n 
1 1188 MET n 
1 1189 GLY n 
1 1190 LYS n 
1 1191 GLN n 
1 1192 GLY n 
1 1193 ARG n 
1 1194 VAL n 
1 1195 LEU n 
1 1196 HIS n 
1 1197 PRO n 
1 1198 GLU n 
1 1199 GLN n 
1 1200 HIS n 
1 1201 ARG n 
1 1202 VAL n 
1 1203 VAL n 
1 1204 SER n 
1 1205 VAL n 
1 1206 ARG n 
1 1207 GLU n 
1 1208 CYS n 
1 1209 ALA n 
1 1210 ARG n 
1 1211 SER n 
1 1212 GLN n 
1 1213 GLY n 
1 1214 PHE n 
1 1215 PRO n 
1 1216 ASP n 
1 1217 THR n 
1 1218 TYR n 
1 1219 ARG n 
1 1220 LEU n 
1 1221 PHE n 
1 1222 GLY n 
1 1223 ASN n 
1 1224 ILE n 
1 1225 LEU n 
1 1226 ASP n 
1 1227 LYS n 
1 1228 HIS n 
1 1229 ARG n 
1 1230 GLN n 
1 1231 VAL n 
1 1232 GLY n 
1 1233 ASN n 
1 1234 ALA n 
1 1235 VAL n 
1 1236 PRO n 
1 1237 PRO n 
1 1238 PRO n 
1 1239 LEU n 
1 1240 ALA n 
1 1241 LYS n 
1 1242 ALA n 
1 1243 ILE n 
1 1244 GLY n 
1 1245 LEU n 
1 1246 GLU n 
1 1247 ILE n 
1 1248 LYS n 
1 1249 LEU n 
1 1250 CYS n 
1 1251 MET n 
1 1252 LEU n 
1 1253 ALA n 
1 1254 LYS n 
1 1255 ALA n 
1 1256 ARG n 
1 1257 GLU n 
1 1258 SER n 
1 1259 ALA n 
1 1260 SER n 
1 1261 ALA n 
1 1262 LYS n 
1 1263 ILE n 
1 1264 LYS n 
1 1265 GLU n 
1 1266 GLU n 
1 1267 GLU n 
1 1268 ALA n 
1 1269 ALA n 
1 1270 LYS n 
1 1271 ASP n 
2 1    DA  n 
2 2    DC  n 
2 3    DT  n 
2 4    DT  n 
2 5    DA  n 
2 6    5CM n 
2 7    DG  n 
2 8    DG  n 
2 9    DA  n 
2 10   DA  n 
2 11   DG  n 
2 12   DG  n 
3 1    DC  n 
3 2    DC  n 
3 3    DT  n 
3 4    DT  n 
3 5    DC  n 
3 6    EIX n 
3 7    DG  n 
3 8    DT  n 
3 9    DA  n 
3 10   DA  n 
3 11   DG  n 
3 12   DT  n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   1271 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'DNMT1, AIM, CXXC9, DNMT' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_src_syn.entity_id 
_pdbx_entity_src_syn.pdbx_src_id 
_pdbx_entity_src_syn.pdbx_alt_source_flag 
_pdbx_entity_src_syn.pdbx_beg_seq_num 
_pdbx_entity_src_syn.pdbx_end_seq_num 
_pdbx_entity_src_syn.organism_scientific 
_pdbx_entity_src_syn.organism_common_name 
_pdbx_entity_src_syn.ncbi_taxonomy_id 
_pdbx_entity_src_syn.details 
2 1 sample 1 12 'synthetic construct' ? 32630 ? 
3 1 sample 1 12 'synthetic construct' ? 32630 ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
5CM 'DNA linking'       n "5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE" ? 'C10 H16 N3 O7 P'     321.224 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O6 P'     331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE" ? 'C9 H14 N3 O7 P'      307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P'     347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE" ? 'C10 H15 N2 O8 P'     322.208 
EIX 'DNA linking'       n 
;[(2R,3S,5S)-5-[(4R,5R)-6-azanyl-5-fluoranyl-5-methyl-2-oxidanylidene-4-sulfanyl-4H-pyrimidin-3-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate
;
? 'C10 H17 F N3 O7 P S' 373.295 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SAH non-polymer         . S-ADENOSYL-L-HOMOCYSTEINE ? 'C14 H20 N6 O5 S'     384.411 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
ZN  non-polymer         . 'ZINC ION' ? 'Zn 2'                65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1    GLY 1    346  ?    ?   ?   A . n 
A 1 2    PRO 2    347  ?    ?   ?   A . n 
A 1 3    PRO 3    348  ?    ?   ?   A . n 
A 1 4    THR 4    349  ?    ?   ?   A . n 
A 1 5    THR 5    350  ?    ?   ?   A . n 
A 1 6    PRO 6    351  ?    ?   ?   A . n 
A 1 7    LYS 7    352  ?    ?   ?   A . n 
A 1 8    CYS 8    353  ?    ?   ?   A . n 
A 1 9    ILE 9    354  ?    ?   ?   A . n 
A 1 10   GLN 10   355  ?    ?   ?   A . n 
A 1 11   CYS 11   356  ?    ?   ?   A . n 
A 1 12   GLY 12   357  ?    ?   ?   A . n 
A 1 13   GLN 13   358  ?    ?   ?   A . n 
A 1 14   TYR 14   359  ?    ?   ?   A . n 
A 1 15   LEU 15   360  ?    ?   ?   A . n 
A 1 16   ASP 16   361  ?    ?   ?   A . n 
A 1 17   ASP 17   362  ?    ?   ?   A . n 
A 1 18   PRO 18   363  ?    ?   ?   A . n 
A 1 19   ASP 19   364  ?    ?   ?   A . n 
A 1 20   LEU 20   365  ?    ?   ?   A . n 
A 1 21   LYS 21   366  ?    ?   ?   A . n 
A 1 22   TYR 22   367  ?    ?   ?   A . n 
A 1 23   GLY 23   368  ?    ?   ?   A . n 
A 1 24   GLN 24   369  ?    ?   ?   A . n 
A 1 25   HIS 25   370  ?    ?   ?   A . n 
A 1 26   PRO 26   371  ?    ?   ?   A . n 
A 1 27   PRO 27   372  ?    ?   ?   A . n 
A 1 28   ASP 28   373  ?    ?   ?   A . n 
A 1 29   ALA 29   374  ?    ?   ?   A . n 
A 1 30   VAL 30   375  ?    ?   ?   A . n 
A 1 31   ASP 31   376  ?    ?   ?   A . n 
A 1 32   GLU 32   377  ?    ?   ?   A . n 
A 1 33   PRO 33   378  ?    ?   ?   A . n 
A 1 34   GLN 34   379  ?    ?   ?   A . n 
A 1 35   MET 35   380  ?    ?   ?   A . n 
A 1 36   LEU 36   381  ?    ?   ?   A . n 
A 1 37   THR 37   382  ?    ?   ?   A . n 
A 1 38   ASN 38   383  ?    ?   ?   A . n 
A 1 39   GLU 39   384  ?    ?   ?   A . n 
A 1 40   LYS 40   385  ?    ?   ?   A . n 
A 1 41   LEU 41   386  ?    ?   ?   A . n 
A 1 42   SER 42   387  ?    ?   ?   A . n 
A 1 43   ILE 43   388  ?    ?   ?   A . n 
A 1 44   PHE 44   389  ?    ?   ?   A . n 
A 1 45   ASP 45   390  ?    ?   ?   A . n 
A 1 46   ALA 46   391  ?    ?   ?   A . n 
A 1 47   ASN 47   392  ?    ?   ?   A . n 
A 1 48   GLU 48   393  ?    ?   ?   A . n 
A 1 49   SER 49   394  ?    ?   ?   A . n 
A 1 50   GLY 50   395  ?    ?   ?   A . n 
A 1 51   PHE 51   396  ?    ?   ?   A . n 
A 1 52   GLU 52   397  ?    ?   ?   A . n 
A 1 53   SER 53   398  ?    ?   ?   A . n 
A 1 54   TYR 54   399  ?    ?   ?   A . n 
A 1 55   GLU 55   400  ?    ?   ?   A . n 
A 1 56   ALA 56   401  ?    ?   ?   A . n 
A 1 57   LEU 57   402  ?    ?   ?   A . n 
A 1 58   PRO 58   403  ?    ?   ?   A . n 
A 1 59   GLN 59   404  ?    ?   ?   A . n 
A 1 60   HIS 60   405  ?    ?   ?   A . n 
A 1 61   LYS 61   406  ?    ?   ?   A . n 
A 1 62   LEU 62   407  ?    ?   ?   A . n 
A 1 63   THR 63   408  ?    ?   ?   A . n 
A 1 64   CYS 64   409  ?    ?   ?   A . n 
A 1 65   PHE 65   410  ?    ?   ?   A . n 
A 1 66   SER 66   411  ?    ?   ?   A . n 
A 1 67   VAL 67   412  ?    ?   ?   A . n 
A 1 68   TYR 68   413  ?    ?   ?   A . n 
A 1 69   CYS 69   414  ?    ?   ?   A . n 
A 1 70   LYS 70   415  ?    ?   ?   A . n 
A 1 71   HIS 71   416  ?    ?   ?   A . n 
A 1 72   GLY 72   417  ?    ?   ?   A . n 
A 1 73   HIS 73   418  ?    ?   ?   A . n 
A 1 74   LEU 74   419  ?    ?   ?   A . n 
A 1 75   CYS 75   420  ?    ?   ?   A . n 
A 1 76   PRO 76   421  ?    ?   ?   A . n 
A 1 77   ILE 77   422  ?    ?   ?   A . n 
A 1 78   ASP 78   423  ?    ?   ?   A . n 
A 1 79   THR 79   424  ?    ?   ?   A . n 
A 1 80   GLY 80   425  ?    ?   ?   A . n 
A 1 81   LEU 81   426  ?    ?   ?   A . n 
A 1 82   ILE 82   427  ?    ?   ?   A . n 
A 1 83   GLU 83   428  ?    ?   ?   A . n 
A 1 84   LYS 84   429  ?    ?   ?   A . n 
A 1 85   ASN 85   430  ?    ?   ?   A . n 
A 1 86   ILE 86   431  ?    ?   ?   A . n 
A 1 87   GLU 87   432  ?    ?   ?   A . n 
A 1 88   LEU 88   433  ?    ?   ?   A . n 
A 1 89   PHE 89   434  ?    ?   ?   A . n 
A 1 90   PHE 90   435  ?    ?   ?   A . n 
A 1 91   SER 91   436  ?    ?   ?   A . n 
A 1 92   GLY 92   437  ?    ?   ?   A . n 
A 1 93   SER 93   438  ?    ?   ?   A . n 
A 1 94   ALA 94   439  ?    ?   ?   A . n 
A 1 95   LYS 95   440  ?    ?   ?   A . n 
A 1 96   PRO 96   441  ?    ?   ?   A . n 
A 1 97   ILE 97   442  ?    ?   ?   A . n 
A 1 98   TYR 98   443  ?    ?   ?   A . n 
A 1 99   ASP 99   444  ?    ?   ?   A . n 
A 1 100  ASP 100  445  ?    ?   ?   A . n 
A 1 101  ASP 101  446  ?    ?   ?   A . n 
A 1 102  PRO 102  447  ?    ?   ?   A . n 
A 1 103  SER 103  448  ?    ?   ?   A . n 
A 1 104  LEU 104  449  ?    ?   ?   A . n 
A 1 105  GLU 105  450  ?    ?   ?   A . n 
A 1 106  GLY 106  451  ?    ?   ?   A . n 
A 1 107  GLY 107  452  ?    ?   ?   A . n 
A 1 108  VAL 108  453  ?    ?   ?   A . n 
A 1 109  ASN 109  454  ?    ?   ?   A . n 
A 1 110  GLY 110  455  ?    ?   ?   A . n 
A 1 111  LYS 111  456  ?    ?   ?   A . n 
A 1 112  ASN 112  457  ?    ?   ?   A . n 
A 1 113  LEU 113  458  ?    ?   ?   A . n 
A 1 114  GLY 114  459  ?    ?   ?   A . n 
A 1 115  PRO 115  460  ?    ?   ?   A . n 
A 1 116  ILE 116  461  ?    ?   ?   A . n 
A 1 117  ASN 117  462  ?    ?   ?   A . n 
A 1 118  GLU 118  463  ?    ?   ?   A . n 
A 1 119  TRP 119  464  ?    ?   ?   A . n 
A 1 120  TRP 120  465  ?    ?   ?   A . n 
A 1 121  ILE 121  466  ?    ?   ?   A . n 
A 1 122  THR 122  467  ?    ?   ?   A . n 
A 1 123  GLY 123  468  ?    ?   ?   A . n 
A 1 124  PHE 124  469  ?    ?   ?   A . n 
A 1 125  ASP 125  470  ?    ?   ?   A . n 
A 1 126  GLY 126  471  ?    ?   ?   A . n 
A 1 127  GLY 127  472  ?    ?   ?   A . n 
A 1 128  GLU 128  473  ?    ?   ?   A . n 
A 1 129  LYS 129  474  ?    ?   ?   A . n 
A 1 130  ALA 130  475  ?    ?   ?   A . n 
A 1 131  LEU 131  476  ?    ?   ?   A . n 
A 1 132  ILE 132  477  ?    ?   ?   A . n 
A 1 133  GLY 133  478  ?    ?   ?   A . n 
A 1 134  PHE 134  479  ?    ?   ?   A . n 
A 1 135  SER 135  480  ?    ?   ?   A . n 
A 1 136  THR 136  481  ?    ?   ?   A . n 
A 1 137  SER 137  482  ?    ?   ?   A . n 
A 1 138  PHE 138  483  ?    ?   ?   A . n 
A 1 139  ALA 139  484  ?    ?   ?   A . n 
A 1 140  GLU 140  485  ?    ?   ?   A . n 
A 1 141  TYR 141  486  ?    ?   ?   A . n 
A 1 142  ILE 142  487  ?    ?   ?   A . n 
A 1 143  LEU 143  488  ?    ?   ?   A . n 
A 1 144  MET 144  489  ?    ?   ?   A . n 
A 1 145  ASP 145  490  ?    ?   ?   A . n 
A 1 146  PRO 146  491  ?    ?   ?   A . n 
A 1 147  SER 147  492  ?    ?   ?   A . n 
A 1 148  PRO 148  493  ?    ?   ?   A . n 
A 1 149  GLU 149  494  ?    ?   ?   A . n 
A 1 150  TYR 150  495  ?    ?   ?   A . n 
A 1 151  ALA 151  496  ?    ?   ?   A . n 
A 1 152  PRO 152  497  ?    ?   ?   A . n 
A 1 153  ILE 153  498  ?    ?   ?   A . n 
A 1 154  PHE 154  499  ?    ?   ?   A . n 
A 1 155  GLY 155  500  ?    ?   ?   A . n 
A 1 156  LEU 156  501  ?    ?   ?   A . n 
A 1 157  MET 157  502  ?    ?   ?   A . n 
A 1 158  GLN 158  503  ?    ?   ?   A . n 
A 1 159  GLU 159  504  ?    ?   ?   A . n 
A 1 160  LYS 160  505  ?    ?   ?   A . n 
A 1 161  ILE 161  506  ?    ?   ?   A . n 
A 1 162  TYR 162  507  ?    ?   ?   A . n 
A 1 163  ILE 163  508  ?    ?   ?   A . n 
A 1 164  SER 164  509  ?    ?   ?   A . n 
A 1 165  LYS 165  510  ?    ?   ?   A . n 
A 1 166  ILE 166  511  ?    ?   ?   A . n 
A 1 167  VAL 167  512  ?    ?   ?   A . n 
A 1 168  VAL 168  513  ?    ?   ?   A . n 
A 1 169  GLU 169  514  ?    ?   ?   A . n 
A 1 170  PHE 170  515  ?    ?   ?   A . n 
A 1 171  LEU 171  516  ?    ?   ?   A . n 
A 1 172  GLN 172  517  ?    ?   ?   A . n 
A 1 173  SER 173  518  ?    ?   ?   A . n 
A 1 174  ASN 174  519  ?    ?   ?   A . n 
A 1 175  SER 175  520  ?    ?   ?   A . n 
A 1 176  ASP 176  521  ?    ?   ?   A . n 
A 1 177  SER 177  522  ?    ?   ?   A . n 
A 1 178  THR 178  523  ?    ?   ?   A . n 
A 1 179  TYR 179  524  ?    ?   ?   A . n 
A 1 180  GLU 180  525  ?    ?   ?   A . n 
A 1 181  ASP 181  526  ?    ?   ?   A . n 
A 1 182  LEU 182  527  ?    ?   ?   A . n 
A 1 183  ILE 183  528  ?    ?   ?   A . n 
A 1 184  ASN 184  529  ?    ?   ?   A . n 
A 1 185  LYS 185  530  ?    ?   ?   A . n 
A 1 186  ILE 186  531  ?    ?   ?   A . n 
A 1 187  GLU 187  532  ?    ?   ?   A . n 
A 1 188  THR 188  533  ?    ?   ?   A . n 
A 1 189  THR 189  534  ?    ?   ?   A . n 
A 1 190  VAL 190  535  ?    ?   ?   A . n 
A 1 191  PRO 191  536  ?    ?   ?   A . n 
A 1 192  PRO 192  537  ?    ?   ?   A . n 
A 1 193  SER 193  538  ?    ?   ?   A . n 
A 1 194  GLY 194  539  ?    ?   ?   A . n 
A 1 195  LEU 195  540  ?    ?   ?   A . n 
A 1 196  ASN 196  541  ?    ?   ?   A . n 
A 1 197  LEU 197  542  ?    ?   ?   A . n 
A 1 198  ASN 198  543  ?    ?   ?   A . n 
A 1 199  ARG 199  544  ?    ?   ?   A . n 
A 1 200  PHE 200  545  ?    ?   ?   A . n 
A 1 201  THR 201  546  ?    ?   ?   A . n 
A 1 202  GLU 202  547  ?    ?   ?   A . n 
A 1 203  ASP 203  548  ?    ?   ?   A . n 
A 1 204  SER 204  549  ?    ?   ?   A . n 
A 1 205  LEU 205  550  ?    ?   ?   A . n 
A 1 206  LEU 206  551  ?    ?   ?   A . n 
A 1 207  ARG 207  552  ?    ?   ?   A . n 
A 1 208  HIS 208  553  ?    ?   ?   A . n 
A 1 209  ALA 209  554  ?    ?   ?   A . n 
A 1 210  GLN 210  555  ?    ?   ?   A . n 
A 1 211  PHE 211  556  ?    ?   ?   A . n 
A 1 212  VAL 212  557  ?    ?   ?   A . n 
A 1 213  VAL 213  558  ?    ?   ?   A . n 
A 1 214  GLU 214  559  ?    ?   ?   A . n 
A 1 215  GLN 215  560  ?    ?   ?   A . n 
A 1 216  VAL 216  561  ?    ?   ?   A . n 
A 1 217  GLU 217  562  ?    ?   ?   A . n 
A 1 218  SER 218  563  ?    ?   ?   A . n 
A 1 219  TYR 219  564  ?    ?   ?   A . n 
A 1 220  ASP 220  565  ?    ?   ?   A . n 
A 1 221  GLU 221  566  ?    ?   ?   A . n 
A 1 222  ALA 222  567  ?    ?   ?   A . n 
A 1 223  GLY 223  568  ?    ?   ?   A . n 
A 1 224  ASP 224  569  ?    ?   ?   A . n 
A 1 225  SER 225  570  ?    ?   ?   A . n 
A 1 226  ASP 226  571  ?    ?   ?   A . n 
A 1 227  GLU 227  572  ?    ?   ?   A . n 
A 1 228  GLN 228  573  ?    ?   ?   A . n 
A 1 229  PRO 229  574  ?    ?   ?   A . n 
A 1 230  ILE 230  575  ?    ?   ?   A . n 
A 1 231  PHE 231  576  ?    ?   ?   A . n 
A 1 232  LEU 232  577  ?    ?   ?   A . n 
A 1 233  THR 233  578  ?    ?   ?   A . n 
A 1 234  PRO 234  579  ?    ?   ?   A . n 
A 1 235  CYS 235  580  ?    ?   ?   A . n 
A 1 236  MET 236  581  ?    ?   ?   A . n 
A 1 237  ARG 237  582  ?    ?   ?   A . n 
A 1 238  ASP 238  583  ?    ?   ?   A . n 
A 1 239  LEU 239  584  ?    ?   ?   A . n 
A 1 240  ILE 240  585  ?    ?   ?   A . n 
A 1 241  LYS 241  586  ?    ?   ?   A . n 
A 1 242  LEU 242  587  ?    ?   ?   A . n 
A 1 243  ALA 243  588  ?    ?   ?   A . n 
A 1 244  GLY 244  589  ?    ?   ?   A . n 
A 1 245  VAL 245  590  ?    ?   ?   A . n 
A 1 246  THR 246  591  ?    ?   ?   A . n 
A 1 247  LEU 247  592  ?    ?   ?   A . n 
A 1 248  GLY 248  593  ?    ?   ?   A . n 
A 1 249  GLN 249  594  ?    ?   ?   A . n 
A 1 250  ARG 250  595  ?    ?   ?   A . n 
A 1 251  ARG 251  596  ?    ?   ?   A . n 
A 1 252  ALA 252  597  ?    ?   ?   A . n 
A 1 253  GLN 253  598  ?    ?   ?   A . n 
A 1 254  ALA 254  599  ?    ?   ?   A . n 
A 1 255  ARG 255  600  ?    ?   ?   A . n 
A 1 256  ARG 256  601  ?    ?   ?   A . n 
A 1 257  GLN 257  602  ?    ?   ?   A . n 
A 1 258  THR 258  603  ?    ?   ?   A . n 
A 1 259  ILE 259  604  ?    ?   ?   A . n 
A 1 260  ARG 260  605  ?    ?   ?   A . n 
A 1 261  HIS 261  606  ?    ?   ?   A . n 
A 1 262  SER 262  607  ?    ?   ?   A . n 
A 1 263  THR 263  608  ?    ?   ?   A . n 
A 1 264  ARG 264  609  ?    ?   ?   A . n 
A 1 265  GLU 265  610  ?    ?   ?   A . n 
A 1 266  LYS 266  611  ?    ?   ?   A . n 
A 1 267  ASP 267  612  ?    ?   ?   A . n 
A 1 268  ARG 268  613  ?    ?   ?   A . n 
A 1 269  GLY 269  614  614  GLY GLY A . n 
A 1 270  PRO 270  615  615  PRO PRO A . n 
A 1 271  THR 271  616  616  THR THR A . n 
A 1 272  LYS 272  617  617  LYS LYS A . n 
A 1 273  ALA 273  618  618  ALA ALA A . n 
A 1 274  THR 274  619  619  THR THR A . n 
A 1 275  THR 275  620  620  THR THR A . n 
A 1 276  THR 276  621  621  THR THR A . n 
A 1 277  LYS 277  622  622  LYS LYS A . n 
A 1 278  LEU 278  623  623  LEU LEU A . n 
A 1 279  VAL 279  624  624  VAL VAL A . n 
A 1 280  TYR 280  625  625  TYR TYR A . n 
A 1 281  GLN 281  626  626  GLN GLN A . n 
A 1 282  ILE 282  627  627  ILE ILE A . n 
A 1 283  PHE 283  628  628  PHE PHE A . n 
A 1 284  ASP 284  629  629  ASP ASP A . n 
A 1 285  THR 285  630  630  THR THR A . n 
A 1 286  PHE 286  631  631  PHE PHE A . n 
A 1 287  PHE 287  632  632  PHE PHE A . n 
A 1 288  ALA 288  633  633  ALA ALA A . n 
A 1 289  GLU 289  634  634  GLU GLU A . n 
A 1 290  GLN 290  635  635  GLN GLN A . n 
A 1 291  ILE 291  636  636  ILE ILE A . n 
A 1 292  GLU 292  637  637  GLU GLU A . n 
A 1 293  LYS 293  638  638  LYS LYS A . n 
A 1 294  ASP 294  639  639  ASP ASP A . n 
A 1 295  ASP 295  640  ?    ?   ?   A . n 
A 1 296  ARG 296  641  ?    ?   ?   A . n 
A 1 297  GLU 297  642  ?    ?   ?   A . n 
A 1 298  ASP 298  643  ?    ?   ?   A . n 
A 1 299  LYS 299  644  ?    ?   ?   A . n 
A 1 300  GLU 300  645  ?    ?   ?   A . n 
A 1 301  ASN 301  646  ?    ?   ?   A . n 
A 1 302  ALA 302  647  ?    ?   ?   A . n 
A 1 303  PHE 303  648  ?    ?   ?   A . n 
A 1 304  LYS 304  649  ?    ?   ?   A . n 
A 1 305  ARG 305  650  ?    ?   ?   A . n 
A 1 306  ARG 306  651  ?    ?   ?   A . n 
A 1 307  ARG 307  652  ?    ?   ?   A . n 
A 1 308  CYS 308  653  ?    ?   ?   A . n 
A 1 309  GLY 309  654  ?    ?   ?   A . n 
A 1 310  VAL 310  655  ?    ?   ?   A . n 
A 1 311  CYS 311  656  ?    ?   ?   A . n 
A 1 312  GLU 312  657  ?    ?   ?   A . n 
A 1 313  VAL 313  658  ?    ?   ?   A . n 
A 1 314  CYS 314  659  ?    ?   ?   A . n 
A 1 315  GLN 315  660  ?    ?   ?   A . n 
A 1 316  GLN 316  661  ?    ?   ?   A . n 
A 1 317  PRO 317  662  ?    ?   ?   A . n 
A 1 318  GLU 318  663  ?    ?   ?   A . n 
A 1 319  CYS 319  664  ?    ?   ?   A . n 
A 1 320  GLY 320  665  ?    ?   ?   A . n 
A 1 321  LYS 321  666  ?    ?   ?   A . n 
A 1 322  CYS 322  667  ?    ?   ?   A . n 
A 1 323  LYS 323  668  ?    ?   ?   A . n 
A 1 324  ALA 324  669  ?    ?   ?   A . n 
A 1 325  CYS 325  670  ?    ?   ?   A . n 
A 1 326  LYS 326  671  ?    ?   ?   A . n 
A 1 327  ASP 327  672  ?    ?   ?   A . n 
A 1 328  MET 328  673  ?    ?   ?   A . n 
A 1 329  VAL 329  674  ?    ?   ?   A . n 
A 1 330  LYS 330  675  ?    ?   ?   A . n 
A 1 331  PHE 331  676  ?    ?   ?   A . n 
A 1 332  GLY 332  677  ?    ?   ?   A . n 
A 1 333  GLY 333  678  ?    ?   ?   A . n 
A 1 334  SER 334  679  ?    ?   ?   A . n 
A 1 335  GLY 335  680  ?    ?   ?   A . n 
A 1 336  ARG 336  681  ?    ?   ?   A . n 
A 1 337  SER 337  682  ?    ?   ?   A . n 
A 1 338  LYS 338  683  ?    ?   ?   A . n 
A 1 339  GLN 339  684  ?    ?   ?   A . n 
A 1 340  ALA 340  685  ?    ?   ?   A . n 
A 1 341  CYS 341  686  ?    ?   ?   A . n 
A 1 342  GLN 342  687  ?    ?   ?   A . n 
A 1 343  GLU 343  688  ?    ?   ?   A . n 
A 1 344  ARG 344  689  ?    ?   ?   A . n 
A 1 345  ARG 345  690  ?    ?   ?   A . n 
A 1 346  CYS 346  691  ?    ?   ?   A . n 
A 1 347  PRO 347  692  ?    ?   ?   A . n 
A 1 348  ASN 348  693  ?    ?   ?   A . n 
A 1 349  MET 349  694  ?    ?   ?   A . n 
A 1 350  ALA 350  695  ?    ?   ?   A . n 
A 1 351  MET 351  696  ?    ?   ?   A . n 
A 1 352  LYS 352  697  ?    ?   ?   A . n 
A 1 353  GLU 353  698  ?    ?   ?   A . n 
A 1 354  ALA 354  699  ?    ?   ?   A . n 
A 1 355  ASP 355  700  ?    ?   ?   A . n 
A 1 356  ASP 356  701  ?    ?   ?   A . n 
A 1 357  ASP 357  702  ?    ?   ?   A . n 
A 1 358  GLU 358  703  ?    ?   ?   A . n 
A 1 359  GLU 359  704  ?    ?   ?   A . n 
A 1 360  VAL 360  705  ?    ?   ?   A . n 
A 1 361  ASP 361  706  ?    ?   ?   A . n 
A 1 362  ASP 362  707  ?    ?   ?   A . n 
A 1 363  ASN 363  708  ?    ?   ?   A . n 
A 1 364  ILE 364  709  ?    ?   ?   A . n 
A 1 365  PRO 365  710  ?    ?   ?   A . n 
A 1 366  GLU 366  711  ?    ?   ?   A . n 
A 1 367  MET 367  712  ?    ?   ?   A . n 
A 1 368  PRO 368  713  ?    ?   ?   A . n 
A 1 369  SER 369  714  ?    ?   ?   A . n 
A 1 370  PRO 370  715  ?    ?   ?   A . n 
A 1 371  LYS 371  716  ?    ?   ?   A . n 
A 1 372  LYS 372  717  ?    ?   ?   A . n 
A 1 373  MET 373  718  ?    ?   ?   A . n 
A 1 374  HIS 374  719  ?    ?   ?   A . n 
A 1 375  GLN 375  720  720  GLN GLN A . n 
A 1 376  GLY 376  721  721  GLY GLY A . n 
A 1 377  LYS 377  722  722  LYS LYS A . n 
A 1 378  LYS 378  723  723  LYS LYS A . n 
A 1 379  LYS 379  724  724  LYS LYS A . n 
A 1 380  LYS 380  725  725  LYS LYS A . n 
A 1 381  GLN 381  726  726  GLN GLN A . n 
A 1 382  ASN 382  727  ?    ?   ?   A . n 
A 1 383  LYS 383  728  ?    ?   ?   A . n 
A 1 384  ASN 384  729  ?    ?   ?   A . n 
A 1 385  ARG 385  730  ?    ?   ?   A . n 
A 1 386  ILE 386  731  731  ILE ILE A . n 
A 1 387  SER 387  732  732  SER SER A . n 
A 1 388  TRP 388  733  733  TRP TRP A . n 
A 1 389  VAL 389  734  734  VAL VAL A . n 
A 1 390  GLY 390  735  ?    ?   ?   A . n 
A 1 391  GLU 391  736  ?    ?   ?   A . n 
A 1 392  ALA 392  737  ?    ?   ?   A . n 
A 1 393  VAL 393  738  ?    ?   ?   A . n 
A 1 394  LYS 394  739  ?    ?   ?   A . n 
A 1 395  THR 395  740  ?    ?   ?   A . n 
A 1 396  ASP 396  741  ?    ?   ?   A . n 
A 1 397  GLY 397  742  ?    ?   ?   A . n 
A 1 398  LYS 398  743  ?    ?   ?   A . n 
A 1 399  LYS 399  744  744  LYS LYS A . n 
A 1 400  SER 400  745  745  SER SER A . n 
A 1 401  TYR 401  746  746  TYR TYR A . n 
A 1 402  TYR 402  747  747  TYR TYR A . n 
A 1 403  LYS 403  748  748  LYS LYS A . n 
A 1 404  LYS 404  749  749  LYS LYS A . n 
A 1 405  VAL 405  750  750  VAL VAL A . n 
A 1 406  CYS 406  751  751  CYS CYS A . n 
A 1 407  ILE 407  752  752  ILE ILE A . n 
A 1 408  ASP 408  753  753  ASP ASP A . n 
A 1 409  ALA 409  754  754  ALA ALA A . n 
A 1 410  GLU 410  755  755  GLU GLU A . n 
A 1 411  THR 411  756  756  THR THR A . n 
A 1 412  LEU 412  757  757  LEU LEU A . n 
A 1 413  GLU 413  758  758  GLU GLU A . n 
A 1 414  VAL 414  759  759  VAL VAL A . n 
A 1 415  GLY 415  760  760  GLY GLY A . n 
A 1 416  ASP 416  761  761  ASP ASP A . n 
A 1 417  CYS 417  762  762  CYS CYS A . n 
A 1 418  VAL 418  763  763  VAL VAL A . n 
A 1 419  SER 419  764  764  SER SER A . n 
A 1 420  VAL 420  765  765  VAL VAL A . n 
A 1 421  ILE 421  766  766  ILE ILE A . n 
A 1 422  PRO 422  767  767  PRO PRO A . n 
A 1 423  ASP 423  768  768  ASP ASP A . n 
A 1 424  ASP 424  769  769  ASP ASP A . n 
A 1 425  SER 425  770  770  SER SER A . n 
A 1 426  SER 426  771  771  SER SER A . n 
A 1 427  LYS 427  772  772  LYS LYS A . n 
A 1 428  PRO 428  773  773  PRO PRO A . n 
A 1 429  LEU 429  774  774  LEU LEU A . n 
A 1 430  TYR 430  775  775  TYR TYR A . n 
A 1 431  LEU 431  776  776  LEU LEU A . n 
A 1 432  ALA 432  777  777  ALA ALA A . n 
A 1 433  ARG 433  778  778  ARG ARG A . n 
A 1 434  VAL 434  779  779  VAL VAL A . n 
A 1 435  THR 435  780  780  THR THR A . n 
A 1 436  ALA 436  781  781  ALA ALA A . n 
A 1 437  LEU 437  782  782  LEU LEU A . n 
A 1 438  TRP 438  783  783  TRP TRP A . n 
A 1 439  GLU 439  784  784  GLU GLU A . n 
A 1 440  ASP 440  785  785  ASP ASP A . n 
A 1 441  SER 441  786  786  SER SER A . n 
A 1 442  SER 442  787  787  SER SER A . n 
A 1 443  ASN 443  788  788  ASN ASN A . n 
A 1 444  GLY 444  789  789  GLY GLY A . n 
A 1 445  GLN 445  790  790  GLN GLN A . n 
A 1 446  MET 446  791  791  MET MET A . n 
A 1 447  PHE 447  792  792  PHE PHE A . n 
A 1 448  HIS 448  793  793  HIS HIS A . n 
A 1 449  ALA 449  794  794  ALA ALA A . n 
A 1 450  HIS 450  795  795  HIS HIS A . n 
A 1 451  TRP 451  796  796  TRP TRP A . n 
A 1 452  PHE 452  797  797  PHE PHE A . n 
A 1 453  CYS 453  798  798  CYS CYS A . n 
A 1 454  ALA 454  799  799  ALA ALA A . n 
A 1 455  GLY 455  800  800  GLY GLY A . n 
A 1 456  THR 456  801  801  THR THR A . n 
A 1 457  ASP 457  802  802  ASP ASP A . n 
A 1 458  THR 458  803  803  THR THR A . n 
A 1 459  VAL 459  804  804  VAL VAL A . n 
A 1 460  LEU 460  805  805  LEU LEU A . n 
A 1 461  GLY 461  806  806  GLY GLY A . n 
A 1 462  ALA 462  807  807  ALA ALA A . n 
A 1 463  THR 463  808  808  THR THR A . n 
A 1 464  SER 464  809  809  SER SER A . n 
A 1 465  ASP 465  810  810  ASP ASP A . n 
A 1 466  PRO 466  811  811  PRO PRO A . n 
A 1 467  LEU 467  812  812  LEU LEU A . n 
A 1 468  GLU 468  813  813  GLU GLU A . n 
A 1 469  LEU 469  814  814  LEU LEU A . n 
A 1 470  PHE 470  815  815  PHE PHE A . n 
A 1 471  LEU 471  816  816  LEU LEU A . n 
A 1 472  VAL 472  817  817  VAL VAL A . n 
A 1 473  ASP 473  818  818  ASP ASP A . n 
A 1 474  GLU 474  819  819  GLU GLU A . n 
A 1 475  CYS 475  820  820  CYS CYS A . n 
A 1 476  GLU 476  821  821  GLU GLU A . n 
A 1 477  ASP 477  822  822  ASP ASP A . n 
A 1 478  MET 478  823  823  MET MET A . n 
A 1 479  GLN 479  824  824  GLN GLN A . n 
A 1 480  LEU 480  825  825  LEU LEU A . n 
A 1 481  SER 481  826  826  SER SER A . n 
A 1 482  TYR 482  827  827  TYR TYR A . n 
A 1 483  ILE 483  828  828  ILE ILE A . n 
A 1 484  HIS 484  829  829  HIS HIS A . n 
A 1 485  SER 485  830  830  SER SER A . n 
A 1 486  LYS 486  831  831  LYS LYS A . n 
A 1 487  VAL 487  832  832  VAL VAL A . n 
A 1 488  LYS 488  833  833  LYS LYS A . n 
A 1 489  VAL 489  834  834  VAL VAL A . n 
A 1 490  ILE 490  835  835  ILE ILE A . n 
A 1 491  TYR 491  836  836  TYR TYR A . n 
A 1 492  LYS 492  837  837  LYS LYS A . n 
A 1 493  ALA 493  838  838  ALA ALA A . n 
A 1 494  PRO 494  839  839  PRO PRO A . n 
A 1 495  SER 495  840  840  SER SER A . n 
A 1 496  GLU 496  841  841  GLU GLU A . n 
A 1 497  ASN 497  842  842  ASN ASN A . n 
A 1 498  TRP 498  843  843  TRP TRP A . n 
A 1 499  ALA 499  844  844  ALA ALA A . n 
A 1 500  MET 500  845  845  MET MET A . n 
A 1 501  GLU 501  846  846  GLU GLU A . n 
A 1 502  GLY 502  847  847  GLY GLY A . n 
A 1 503  GLY 503  848  848  GLY GLY A . n 
A 1 504  MET 504  849  849  MET MET A . n 
A 1 505  ASP 505  850  ?    ?   ?   A . n 
A 1 506  PRO 506  851  ?    ?   ?   A . n 
A 1 507  GLU 507  852  ?    ?   ?   A . n 
A 1 508  SER 508  853  ?    ?   ?   A . n 
A 1 509  LEU 509  854  ?    ?   ?   A . n 
A 1 510  LEU 510  855  ?    ?   ?   A . n 
A 1 511  GLU 511  856  ?    ?   ?   A . n 
A 1 512  GLY 512  857  ?    ?   ?   A . n 
A 1 513  ASP 513  858  ?    ?   ?   A . n 
A 1 514  ASP 514  859  ?    ?   ?   A . n 
A 1 515  GLY 515  860  860  GLY GLY A . n 
A 1 516  LYS 516  861  861  LYS LYS A . n 
A 1 517  THR 517  862  862  THR THR A . n 
A 1 518  TYR 518  863  863  TYR TYR A . n 
A 1 519  PHE 519  864  864  PHE PHE A . n 
A 1 520  TYR 520  865  865  TYR TYR A . n 
A 1 521  GLN 521  866  866  GLN GLN A . n 
A 1 522  LEU 522  867  867  LEU LEU A . n 
A 1 523  TRP 523  868  868  TRP TRP A . n 
A 1 524  TYR 524  869  869  TYR TYR A . n 
A 1 525  ASP 525  870  870  ASP ASP A . n 
A 1 526  GLN 526  871  871  GLN GLN A . n 
A 1 527  ASP 527  872  872  ASP ASP A . n 
A 1 528  TYR 528  873  873  TYR TYR A . n 
A 1 529  ALA 529  874  874  ALA ALA A . n 
A 1 530  ARG 530  875  875  ARG ARG A . n 
A 1 531  PHE 531  876  876  PHE PHE A . n 
A 1 532  GLU 532  877  877  GLU GLU A . n 
A 1 533  SER 533  878  878  SER SER A . n 
A 1 534  PRO 534  879  879  PRO PRO A . n 
A 1 535  PRO 535  880  880  PRO PRO A . n 
A 1 536  LYS 536  881  881  LYS LYS A . n 
A 1 537  THR 537  882  882  THR THR A . n 
A 1 538  GLN 538  883  ?    ?   ?   A . n 
A 1 539  PRO 539  884  ?    ?   ?   A . n 
A 1 540  THR 540  885  ?    ?   ?   A . n 
A 1 541  GLU 541  886  ?    ?   ?   A . n 
A 1 542  ASP 542  887  ?    ?   ?   A . n 
A 1 543  ASN 543  888  ?    ?   ?   A . n 
A 1 544  LYS 544  889  ?    ?   ?   A . n 
A 1 545  PHE 545  890  890  PHE PHE A . n 
A 1 546  LYS 546  891  891  LYS LYS A . n 
A 1 547  PHE 547  892  892  PHE PHE A . n 
A 1 548  CYS 548  893  893  CYS CYS A . n 
A 1 549  VAL 549  894  894  VAL VAL A . n 
A 1 550  SER 550  895  895  SER SER A . n 
A 1 551  CYS 551  896  896  CYS CYS A . n 
A 1 552  ALA 552  897  897  ALA ALA A . n 
A 1 553  ARG 553  898  898  ARG ARG A . n 
A 1 554  LEU 554  899  899  LEU LEU A . n 
A 1 555  ALA 555  900  900  ALA ALA A . n 
A 1 556  GLU 556  901  901  GLU GLU A . n 
A 1 557  MET 557  902  902  MET MET A . n 
A 1 558  ARG 558  903  903  ARG ARG A . n 
A 1 559  GLN 559  904  904  GLN GLN A . n 
A 1 560  LYS 560  905  905  LYS LYS A . n 
A 1 561  GLU 561  906  906  GLU GLU A . n 
A 1 562  ILE 562  907  907  ILE ILE A . n 
A 1 563  PRO 563  908  908  PRO PRO A . n 
A 1 564  ARG 564  909  909  ARG ARG A . n 
A 1 565  VAL 565  910  910  VAL VAL A . n 
A 1 566  LEU 566  911  911  LEU LEU A . n 
A 1 567  GLU 567  912  912  GLU GLU A . n 
A 1 568  GLN 568  913  913  GLN GLN A . n 
A 1 569  LEU 569  914  914  LEU LEU A . n 
A 1 570  GLU 570  915  915  GLU GLU A . n 
A 1 571  ASP 571  916  916  ASP ASP A . n 
A 1 572  LEU 572  917  917  LEU LEU A . n 
A 1 573  ASP 573  918  918  ASP ASP A . n 
A 1 574  SER 574  919  919  SER SER A . n 
A 1 575  ARG 575  920  920  ARG ARG A . n 
A 1 576  VAL 576  921  921  VAL VAL A . n 
A 1 577  LEU 577  922  922  LEU LEU A . n 
A 1 578  TYR 578  923  923  TYR TYR A . n 
A 1 579  TYR 579  924  924  TYR TYR A . n 
A 1 580  SER 580  925  925  SER SER A . n 
A 1 581  ALA 581  926  926  ALA ALA A . n 
A 1 582  THR 582  927  927  THR THR A . n 
A 1 583  LYS 583  928  928  LYS LYS A . n 
A 1 584  ASN 584  929  929  ASN ASN A . n 
A 1 585  GLY 585  930  930  GLY GLY A . n 
A 1 586  ILE 586  931  931  ILE ILE A . n 
A 1 587  LEU 587  932  932  LEU LEU A . n 
A 1 588  TYR 588  933  933  TYR TYR A . n 
A 1 589  ARG 589  934  934  ARG ARG A . n 
A 1 590  VAL 590  935  935  VAL VAL A . n 
A 1 591  GLY 591  936  936  GLY GLY A . n 
A 1 592  ASP 592  937  937  ASP ASP A . n 
A 1 593  GLY 593  938  938  GLY GLY A . n 
A 1 594  VAL 594  939  939  VAL VAL A . n 
A 1 595  TYR 595  940  940  TYR TYR A . n 
A 1 596  LEU 596  941  941  LEU LEU A . n 
A 1 597  PRO 597  942  942  PRO PRO A . n 
A 1 598  PRO 598  943  943  PRO PRO A . n 
A 1 599  GLU 599  944  944  GLU GLU A . n 
A 1 600  ALA 600  945  945  ALA ALA A . n 
A 1 601  PHE 601  946  946  PHE PHE A . n 
A 1 602  THR 602  947  947  THR THR A . n 
A 1 603  PHE 603  948  948  PHE PHE A . n 
A 1 604  ASN 604  949  949  ASN ASN A . n 
A 1 605  ILE 605  950  950  ILE ILE A . n 
A 1 606  LYS 606  951  951  LYS LYS A . n 
A 1 607  LEU 607  952  952  LEU LEU A . n 
A 1 608  SER 608  953  953  SER SER A . n 
A 1 609  SER 609  954  ?    ?   ?   A . n 
A 1 610  PRO 610  955  ?    ?   ?   A . n 
A 1 611  VAL 611  956  ?    ?   ?   A . n 
A 1 612  LYS 612  957  ?    ?   ?   A . n 
A 1 613  ARG 613  958  ?    ?   ?   A . n 
A 1 614  PRO 614  959  ?    ?   ?   A . n 
A 1 615  ARG 615  960  ?    ?   ?   A . n 
A 1 616  LYS 616  961  ?    ?   ?   A . n 
A 1 617  GLU 617  962  962  GLU GLU A . n 
A 1 618  PRO 618  963  963  PRO PRO A . n 
A 1 619  VAL 619  964  964  VAL VAL A . n 
A 1 620  ASP 620  965  965  ASP ASP A . n 
A 1 621  GLU 621  966  966  GLU GLU A . n 
A 1 622  ASP 622  967  967  ASP ASP A . n 
A 1 623  LEU 623  968  968  LEU LEU A . n 
A 1 624  TYR 624  969  969  TYR TYR A . n 
A 1 625  PRO 625  970  970  PRO PRO A . n 
A 1 626  GLU 626  971  971  GLU GLU A . n 
A 1 627  HIS 627  972  972  HIS HIS A . n 
A 1 628  TYR 628  973  973  TYR TYR A . n 
A 1 629  ARG 629  974  974  ARG ARG A . n 
A 1 630  LYS 630  975  975  LYS LYS A . n 
A 1 631  TYR 631  976  976  TYR TYR A . n 
A 1 632  SER 632  977  977  SER SER A . n 
A 1 633  ASP 633  978  978  ASP ASP A . n 
A 1 634  TYR 634  979  979  TYR TYR A . n 
A 1 635  ILE 635  980  980  ILE ILE A . n 
A 1 636  LYS 636  981  981  LYS LYS A . n 
A 1 637  GLY 637  982  982  GLY GLY A . n 
A 1 638  SER 638  983  983  SER SER A . n 
A 1 639  ASN 639  984  984  ASN ASN A . n 
A 1 640  LEU 640  985  985  LEU LEU A . n 
A 1 641  ASP 641  986  986  ASP ASP A . n 
A 1 642  ALA 642  987  987  ALA ALA A . n 
A 1 643  PRO 643  988  988  PRO PRO A . n 
A 1 644  GLU 644  989  989  GLU GLU A . n 
A 1 645  PRO 645  990  990  PRO PRO A . n 
A 1 646  TYR 646  991  991  TYR TYR A . n 
A 1 647  ARG 647  992  992  ARG ARG A . n 
A 1 648  ILE 648  993  993  ILE ILE A . n 
A 1 649  GLY 649  994  994  GLY GLY A . n 
A 1 650  ARG 650  995  995  ARG ARG A . n 
A 1 651  ILE 651  996  996  ILE ILE A . n 
A 1 652  LYS 652  997  997  LYS LYS A . n 
A 1 653  GLU 653  998  998  GLU GLU A . n 
A 1 654  ILE 654  999  999  ILE ILE A . n 
A 1 655  PHE 655  1000 1000 PHE PHE A . n 
A 1 656  CYS 656  1001 1001 CYS CYS A . n 
A 1 657  PRO 657  1002 1002 PRO PRO A . n 
A 1 658  LYS 658  1003 1003 LYS LYS A . n 
A 1 659  LYS 659  1004 1004 LYS LYS A . n 
A 1 660  SER 660  1005 1005 SER SER A . n 
A 1 661  ASN 661  1006 1006 ASN ASN A . n 
A 1 662  GLY 662  1007 1007 GLY GLY A . n 
A 1 663  ARG 663  1008 1008 ARG ARG A . n 
A 1 664  PRO 664  1009 1009 PRO PRO A . n 
A 1 665  ASN 665  1010 1010 ASN ASN A . n 
A 1 666  GLU 666  1011 1011 GLU GLU A . n 
A 1 667  THR 667  1012 1012 THR THR A . n 
A 1 668  ASP 668  1013 1013 ASP ASP A . n 
A 1 669  ILE 669  1014 1014 ILE ILE A . n 
A 1 670  LYS 670  1015 1015 LYS LYS A . n 
A 1 671  ILE 671  1016 1016 ILE ILE A . n 
A 1 672  ARG 672  1017 1017 ARG ARG A . n 
A 1 673  VAL 673  1018 1018 VAL VAL A . n 
A 1 674  ASN 674  1019 1019 ASN ASN A . n 
A 1 675  LYS 675  1020 1020 LYS LYS A . n 
A 1 676  PHE 676  1021 1021 PHE PHE A . n 
A 1 677  TYR 677  1022 1022 TYR TYR A . n 
A 1 678  ARG 678  1023 1023 ARG ARG A . n 
A 1 679  PRO 679  1024 1024 PRO PRO A . n 
A 1 680  GLU 680  1025 1025 GLU GLU A . n 
A 1 681  ASN 681  1026 1026 ASN ASN A . n 
A 1 682  THR 682  1027 1027 THR THR A . n 
A 1 683  HIS 683  1028 1028 HIS HIS A . n 
A 1 684  LYS 684  1029 1029 LYS LYS A . n 
A 1 685  SER 685  1030 1030 SER SER A . n 
A 1 686  THR 686  1031 1031 THR THR A . n 
A 1 687  PRO 687  1032 1032 PRO PRO A . n 
A 1 688  ALA 688  1033 1033 ALA ALA A . n 
A 1 689  SER 689  1034 1034 SER SER A . n 
A 1 690  TYR 690  1035 1035 TYR TYR A . n 
A 1 691  HIS 691  1036 1036 HIS HIS A . n 
A 1 692  ALA 692  1037 1037 ALA ALA A . n 
A 1 693  ASP 693  1038 1038 ASP ASP A . n 
A 1 694  ILE 694  1039 1039 ILE ILE A . n 
A 1 695  ASN 695  1040 1040 ASN ASN A . n 
A 1 696  LEU 696  1041 1041 LEU LEU A . n 
A 1 697  LEU 697  1042 1042 LEU LEU A . n 
A 1 698  TYR 698  1043 1043 TYR TYR A . n 
A 1 699  TRP 699  1044 1044 TRP TRP A . n 
A 1 700  SER 700  1045 1045 SER SER A . n 
A 1 701  ASP 701  1046 1046 ASP ASP A . n 
A 1 702  GLU 702  1047 1047 GLU GLU A . n 
A 1 703  GLU 703  1048 1048 GLU GLU A . n 
A 1 704  ALA 704  1049 1049 ALA ALA A . n 
A 1 705  VAL 705  1050 1050 VAL VAL A . n 
A 1 706  VAL 706  1051 1051 VAL VAL A . n 
A 1 707  ASP 707  1052 1052 ASP ASP A . n 
A 1 708  PHE 708  1053 1053 PHE PHE A . n 
A 1 709  LYS 709  1054 1054 LYS LYS A . n 
A 1 710  ALA 710  1055 1055 ALA ALA A . n 
A 1 711  VAL 711  1056 1056 VAL VAL A . n 
A 1 712  GLN 712  1057 1057 GLN GLN A . n 
A 1 713  GLY 713  1058 1058 GLY GLY A . n 
A 1 714  ARG 714  1059 1059 ARG ARG A . n 
A 1 715  CYS 715  1060 1060 CYS CYS A . n 
A 1 716  THR 716  1061 1061 THR THR A . n 
A 1 717  VAL 717  1062 1062 VAL VAL A . n 
A 1 718  GLU 718  1063 1063 GLU GLU A . n 
A 1 719  TYR 719  1064 1064 TYR TYR A . n 
A 1 720  GLY 720  1065 1065 GLY GLY A . n 
A 1 721  GLU 721  1066 1066 GLU GLU A . n 
A 1 722  ASP 722  1067 1067 ASP ASP A . n 
A 1 723  LEU 723  1068 1068 LEU LEU A . n 
A 1 724  PRO 724  1069 1069 PRO PRO A . n 
A 1 725  GLU 725  1070 1070 GLU GLU A . n 
A 1 726  CYS 726  1071 1071 CYS CYS A . n 
A 1 727  VAL 727  1072 1072 VAL VAL A . n 
A 1 728  GLN 728  1073 1073 GLN GLN A . n 
A 1 729  VAL 729  1074 1074 VAL VAL A . n 
A 1 730  TYR 730  1075 1075 TYR TYR A . n 
A 1 731  SER 731  1076 1076 SER SER A . n 
A 1 732  MET 732  1077 1077 MET MET A . n 
A 1 733  GLY 733  1078 1078 GLY GLY A . n 
A 1 734  GLY 734  1079 1079 GLY GLY A . n 
A 1 735  PRO 735  1080 1080 PRO PRO A . n 
A 1 736  ASN 736  1081 1081 ASN ASN A . n 
A 1 737  ARG 737  1082 1082 ARG ARG A . n 
A 1 738  PHE 738  1083 1083 PHE PHE A . n 
A 1 739  TYR 739  1084 1084 TYR TYR A . n 
A 1 740  PHE 740  1085 1085 PHE PHE A . n 
A 1 741  LEU 741  1086 1086 LEU LEU A . n 
A 1 742  GLU 742  1087 1087 GLU GLU A . n 
A 1 743  ALA 743  1088 1088 ALA ALA A . n 
A 1 744  TYR 744  1089 1089 TYR TYR A . n 
A 1 745  ASN 745  1090 1090 ASN ASN A . n 
A 1 746  ALA 746  1091 1091 ALA ALA A . n 
A 1 747  LYS 747  1092 1092 LYS LYS A . n 
A 1 748  SER 748  1093 1093 SER SER A . n 
A 1 749  LYS 749  1094 1094 LYS LYS A . n 
A 1 750  SER 750  1095 1095 SER SER A . n 
A 1 751  PHE 751  1096 1096 PHE PHE A . n 
A 1 752  GLU 752  1097 1097 GLU GLU A . n 
A 1 753  ASP 753  1098 1098 ASP ASP A . n 
A 1 754  PRO 754  1099 1099 PRO PRO A . n 
A 1 755  PRO 755  1100 1100 PRO PRO A . n 
A 1 756  ASN 756  1101 1101 ASN ASN A . n 
A 1 757  HIS 757  1102 1102 HIS HIS A . n 
A 1 758  ALA 758  1103 1103 ALA ALA A . n 
A 1 759  ARG 759  1104 1104 ARG ARG A . n 
A 1 760  SER 760  1105 1105 SER SER A . n 
A 1 761  PRO 761  1106 1106 PRO PRO A . n 
A 1 762  GLY 762  1107 ?    ?   ?   A . n 
A 1 763  ASN 763  1108 ?    ?   ?   A . n 
A 1 764  LYS 764  1109 ?    ?   ?   A . n 
A 1 765  GLY 765  1110 ?    ?   ?   A . n 
A 1 766  LYS 766  1111 ?    ?   ?   A . n 
A 1 767  GLY 767  1112 ?    ?   ?   A . n 
A 1 768  LYS 768  1113 ?    ?   ?   A . n 
A 1 769  GLY 769  1114 ?    ?   ?   A . n 
A 1 770  LYS 770  1115 ?    ?   ?   A . n 
A 1 771  GLY 771  1116 ?    ?   ?   A . n 
A 1 772  LYS 772  1117 ?    ?   ?   A . n 
A 1 773  GLY 773  1118 ?    ?   ?   A . n 
A 1 774  LYS 774  1119 ?    ?   ?   A . n 
A 1 775  PRO 775  1120 ?    ?   ?   A . n 
A 1 776  LYS 776  1121 ?    ?   ?   A . n 
A 1 777  SER 777  1122 ?    ?   ?   A . n 
A 1 778  GLN 778  1123 ?    ?   ?   A . n 
A 1 779  ALA 779  1124 ?    ?   ?   A . n 
A 1 780  CYS 780  1125 ?    ?   ?   A . n 
A 1 781  GLU 781  1126 ?    ?   ?   A . n 
A 1 782  PRO 782  1127 ?    ?   ?   A . n 
A 1 783  SER 783  1128 ?    ?   ?   A . n 
A 1 784  GLU 784  1129 ?    ?   ?   A . n 
A 1 785  PRO 785  1130 ?    ?   ?   A . n 
A 1 786  GLU 786  1131 ?    ?   ?   A . n 
A 1 787  ILE 787  1132 ?    ?   ?   A . n 
A 1 788  GLU 788  1133 ?    ?   ?   A . n 
A 1 789  ILE 789  1134 ?    ?   ?   A . n 
A 1 790  LYS 790  1135 1135 LYS LYS A . n 
A 1 791  LEU 791  1136 1136 LEU LEU A . n 
A 1 792  PRO 792  1137 1137 PRO PRO A . n 
A 1 793  LYS 793  1138 1138 LYS LYS A . n 
A 1 794  LEU 794  1139 1139 LEU LEU A . n 
A 1 795  ARG 795  1140 1140 ARG ARG A . n 
A 1 796  THR 796  1141 1141 THR THR A . n 
A 1 797  LEU 797  1142 1142 LEU LEU A . n 
A 1 798  ASP 798  1143 1143 ASP ASP A . n 
A 1 799  VAL 799  1144 1144 VAL VAL A . n 
A 1 800  PHE 800  1145 1145 PHE PHE A . n 
A 1 801  SER 801  1146 1146 SER SER A . n 
A 1 802  GLY 802  1147 1147 GLY GLY A . n 
A 1 803  CYS 803  1148 1148 CYS CYS A . n 
A 1 804  GLY 804  1149 1149 GLY GLY A . n 
A 1 805  GLY 805  1150 1150 GLY GLY A . n 
A 1 806  LEU 806  1151 1151 LEU LEU A . n 
A 1 807  SER 807  1152 1152 SER SER A . n 
A 1 808  GLU 808  1153 1153 GLU GLU A . n 
A 1 809  GLY 809  1154 1154 GLY GLY A . n 
A 1 810  PHE 810  1155 1155 PHE PHE A . n 
A 1 811  HIS 811  1156 1156 HIS HIS A . n 
A 1 812  GLN 812  1157 1157 GLN GLN A . n 
A 1 813  ALA 813  1158 1158 ALA ALA A . n 
A 1 814  GLY 814  1159 1159 GLY GLY A . n 
A 1 815  ILE 815  1160 1160 ILE ILE A . n 
A 1 816  SER 816  1161 1161 SER SER A . n 
A 1 817  ASP 817  1162 1162 ASP ASP A . n 
A 1 818  THR 818  1163 1163 THR THR A . n 
A 1 819  LEU 819  1164 1164 LEU LEU A . n 
A 1 820  TRP 820  1165 1165 TRP TRP A . n 
A 1 821  ALA 821  1166 1166 ALA ALA A . n 
A 1 822  ILE 822  1167 1167 ILE ILE A . n 
A 1 823  GLU 823  1168 1168 GLU GLU A . n 
A 1 824  MET 824  1169 1169 MET MET A . n 
A 1 825  TRP 825  1170 1170 TRP TRP A . n 
A 1 826  ASP 826  1171 1171 ASP ASP A . n 
A 1 827  PRO 827  1172 1172 PRO PRO A . n 
A 1 828  ALA 828  1173 1173 ALA ALA A . n 
A 1 829  ALA 829  1174 1174 ALA ALA A . n 
A 1 830  GLN 830  1175 1175 GLN GLN A . n 
A 1 831  ALA 831  1176 1176 ALA ALA A . n 
A 1 832  PHE 832  1177 1177 PHE PHE A . n 
A 1 833  ARG 833  1178 1178 ARG ARG A . n 
A 1 834  LEU 834  1179 1179 LEU LEU A . n 
A 1 835  ASN 835  1180 1180 ASN ASN A . n 
A 1 836  ASN 836  1181 1181 ASN ASN A . n 
A 1 837  PRO 837  1182 1182 PRO PRO A . n 
A 1 838  GLY 838  1183 1183 GLY GLY A . n 
A 1 839  SER 839  1184 1184 SER SER A . n 
A 1 840  THR 840  1185 1185 THR THR A . n 
A 1 841  VAL 841  1186 1186 VAL VAL A . n 
A 1 842  PHE 842  1187 1187 PHE PHE A . n 
A 1 843  THR 843  1188 1188 THR THR A . n 
A 1 844  GLU 844  1189 1189 GLU GLU A . n 
A 1 845  ASP 845  1190 1190 ASP ASP A . n 
A 1 846  CYS 846  1191 1191 CYS CYS A . n 
A 1 847  ASN 847  1192 1192 ASN ASN A . n 
A 1 848  ILE 848  1193 1193 ILE ILE A . n 
A 1 849  LEU 849  1194 1194 LEU LEU A . n 
A 1 850  LEU 850  1195 1195 LEU LEU A . n 
A 1 851  LYS 851  1196 1196 LYS LYS A . n 
A 1 852  LEU 852  1197 1197 LEU LEU A . n 
A 1 853  VAL 853  1198 1198 VAL VAL A . n 
A 1 854  MET 854  1199 1199 MET MET A . n 
A 1 855  ALA 855  1200 1200 ALA ALA A . n 
A 1 856  GLY 856  1201 1201 GLY GLY A . n 
A 1 857  GLU 857  1202 1202 GLU GLU A . n 
A 1 858  THR 858  1203 1203 THR THR A . n 
A 1 859  THR 859  1204 1204 THR THR A . n 
A 1 860  ASN 860  1205 1205 ASN ASN A . n 
A 1 861  SER 861  1206 1206 SER SER A . n 
A 1 862  ARG 862  1207 1207 ARG ARG A . n 
A 1 863  GLY 863  1208 1208 GLY GLY A . n 
A 1 864  GLN 864  1209 1209 GLN GLN A . n 
A 1 865  ARG 865  1210 1210 ARG ARG A . n 
A 1 866  LEU 866  1211 1211 LEU LEU A . n 
A 1 867  PRO 867  1212 1212 PRO PRO A . n 
A 1 868  GLN 868  1213 1213 GLN GLN A . n 
A 1 869  LYS 869  1214 1214 LYS LYS A . n 
A 1 870  GLY 870  1215 1215 GLY GLY A . n 
A 1 871  ASP 871  1216 1216 ASP ASP A . n 
A 1 872  VAL 872  1217 1217 VAL VAL A . n 
A 1 873  GLU 873  1218 1218 GLU GLU A . n 
A 1 874  MET 874  1219 1219 MET MET A . n 
A 1 875  LEU 875  1220 1220 LEU LEU A . n 
A 1 876  CYS 876  1221 1221 CYS CYS A . n 
A 1 877  GLY 877  1222 1222 GLY GLY A . n 
A 1 878  GLY 878  1223 1223 GLY GLY A . n 
A 1 879  PRO 879  1224 1224 PRO PRO A . n 
A 1 880  PRO 880  1225 1225 PRO PRO A . n 
A 1 881  CYS 881  1226 1226 CYS CYS A . n 
A 1 882  GLN 882  1227 1227 GLN GLN A . n 
A 1 883  GLY 883  1228 1228 GLY GLY A . n 
A 1 884  PHE 884  1229 1229 PHE PHE A . n 
A 1 885  SER 885  1230 1230 SER SER A . n 
A 1 886  GLY 886  1231 1231 GLY GLY A . n 
A 1 887  MET 887  1232 1232 MET MET A . n 
A 1 888  ASN 888  1233 1233 ASN ASN A . n 
A 1 889  ARG 889  1234 1234 ARG ARG A . n 
A 1 890  PHE 890  1235 1235 PHE PHE A . n 
A 1 891  ASN 891  1236 1236 ASN ASN A . n 
A 1 892  SER 892  1237 1237 SER SER A . n 
A 1 893  ARG 893  1238 1238 ARG ARG A . n 
A 1 894  THR 894  1239 1239 THR THR A . n 
A 1 895  TYR 895  1240 1240 TYR TYR A . n 
A 1 896  SER 896  1241 1241 SER SER A . n 
A 1 897  LYS 897  1242 1242 LYS LYS A . n 
A 1 898  PHE 898  1243 1243 PHE PHE A . n 
A 1 899  LYS 899  1244 1244 LYS LYS A . n 
A 1 900  ASN 900  1245 1245 ASN ASN A . n 
A 1 901  SER 901  1246 1246 SER SER A . n 
A 1 902  LEU 902  1247 1247 LEU LEU A . n 
A 1 903  VAL 903  1248 1248 VAL VAL A . n 
A 1 904  VAL 904  1249 1249 VAL VAL A . n 
A 1 905  SER 905  1250 1250 SER SER A . n 
A 1 906  PHE 906  1251 1251 PHE PHE A . n 
A 1 907  LEU 907  1252 1252 LEU LEU A . n 
A 1 908  SER 908  1253 1253 SER SER A . n 
A 1 909  TYR 909  1254 1254 TYR TYR A . n 
A 1 910  CYS 910  1255 1255 CYS CYS A . n 
A 1 911  ASP 911  1256 1256 ASP ASP A . n 
A 1 912  TYR 912  1257 1257 TYR TYR A . n 
A 1 913  TYR 913  1258 1258 TYR TYR A . n 
A 1 914  ARG 914  1259 1259 ARG ARG A . n 
A 1 915  PRO 915  1260 1260 PRO PRO A . n 
A 1 916  ARG 916  1261 1261 ARG ARG A . n 
A 1 917  PHE 917  1262 1262 PHE PHE A . n 
A 1 918  PHE 918  1263 1263 PHE PHE A . n 
A 1 919  LEU 919  1264 1264 LEU LEU A . n 
A 1 920  LEU 920  1265 1265 LEU LEU A . n 
A 1 921  GLU 921  1266 1266 GLU GLU A . n 
A 1 922  ASN 922  1267 1267 ASN ASN A . n 
A 1 923  VAL 923  1268 1268 VAL VAL A . n 
A 1 924  ARG 924  1269 1269 ARG ARG A . n 
A 1 925  ASN 925  1270 1270 ASN ASN A . n 
A 1 926  PHE 926  1271 1271 PHE PHE A . n 
A 1 927  VAL 927  1272 1272 VAL VAL A . n 
A 1 928  SER 928  1273 1273 SER SER A . n 
A 1 929  PHE 929  1274 1274 PHE PHE A . n 
A 1 930  LYS 930  1275 1275 LYS LYS A . n 
A 1 931  ARG 931  1276 1276 ARG ARG A . n 
A 1 932  SER 932  1277 1277 SER SER A . n 
A 1 933  MET 933  1278 1278 MET MET A . n 
A 1 934  VAL 934  1279 1279 VAL VAL A . n 
A 1 935  LEU 935  1280 1280 LEU LEU A . n 
A 1 936  LYS 936  1281 1281 LYS LYS A . n 
A 1 937  LEU 937  1282 1282 LEU LEU A . n 
A 1 938  THR 938  1283 1283 THR THR A . n 
A 1 939  LEU 939  1284 1284 LEU LEU A . n 
A 1 940  ARG 940  1285 1285 ARG ARG A . n 
A 1 941  CYS 941  1286 1286 CYS CYS A . n 
A 1 942  LEU 942  1287 1287 LEU LEU A . n 
A 1 943  VAL 943  1288 1288 VAL VAL A . n 
A 1 944  ARG 944  1289 1289 ARG ARG A . n 
A 1 945  MET 945  1290 1290 MET MET A . n 
A 1 946  GLY 946  1291 1291 GLY GLY A . n 
A 1 947  TYR 947  1292 1292 TYR TYR A . n 
A 1 948  GLN 948  1293 1293 GLN GLN A . n 
A 1 949  CYS 949  1294 1294 CYS CYS A . n 
A 1 950  THR 950  1295 1295 THR THR A . n 
A 1 951  PHE 951  1296 1296 PHE PHE A . n 
A 1 952  GLY 952  1297 1297 GLY GLY A . n 
A 1 953  VAL 953  1298 1298 VAL VAL A . n 
A 1 954  LEU 954  1299 1299 LEU LEU A . n 
A 1 955  GLN 955  1300 1300 GLN GLN A . n 
A 1 956  ALA 956  1301 1301 ALA ALA A . n 
A 1 957  GLY 957  1302 1302 GLY GLY A . n 
A 1 958  GLN 958  1303 1303 GLN GLN A . n 
A 1 959  TYR 959  1304 1304 TYR TYR A . n 
A 1 960  GLY 960  1305 1305 GLY GLY A . n 
A 1 961  VAL 961  1306 1306 VAL VAL A . n 
A 1 962  ALA 962  1307 1307 ALA ALA A . n 
A 1 963  GLN 963  1308 1308 GLN GLN A . n 
A 1 964  THR 964  1309 1309 THR THR A . n 
A 1 965  ARG 965  1310 1310 ARG ARG A . n 
A 1 966  ARG 966  1311 1311 ARG ARG A . n 
A 1 967  ARG 967  1312 1312 ARG ARG A . n 
A 1 968  ALA 968  1313 1313 ALA ALA A . n 
A 1 969  ILE 969  1314 1314 ILE ILE A . n 
A 1 970  ILE 970  1315 1315 ILE ILE A . n 
A 1 971  LEU 971  1316 1316 LEU LEU A . n 
A 1 972  ALA 972  1317 1317 ALA ALA A . n 
A 1 973  ALA 973  1318 1318 ALA ALA A . n 
A 1 974  ALA 974  1319 1319 ALA ALA A . n 
A 1 975  PRO 975  1320 1320 PRO PRO A . n 
A 1 976  GLY 976  1321 1321 GLY GLY A . n 
A 1 977  GLU 977  1322 1322 GLU GLU A . n 
A 1 978  LYS 978  1323 1323 LYS LYS A . n 
A 1 979  LEU 979  1324 1324 LEU LEU A . n 
A 1 980  PRO 980  1325 1325 PRO PRO A . n 
A 1 981  LEU 981  1326 1326 LEU LEU A . n 
A 1 982  PHE 982  1327 1327 PHE PHE A . n 
A 1 983  PRO 983  1328 1328 PRO PRO A . n 
A 1 984  GLU 984  1329 1329 GLU GLU A . n 
A 1 985  PRO 985  1330 1330 PRO PRO A . n 
A 1 986  LEU 986  1331 1331 LEU LEU A . n 
A 1 987  HIS 987  1332 1332 HIS HIS A . n 
A 1 988  VAL 988  1333 1333 VAL VAL A . n 
A 1 989  PHE 989  1334 1334 PHE PHE A . n 
A 1 990  ALA 990  1335 1335 ALA ALA A . n 
A 1 991  PRO 991  1336 1336 PRO PRO A . n 
A 1 992  ARG 992  1337 1337 ARG ARG A . n 
A 1 993  ALA 993  1338 1338 ALA ALA A . n 
A 1 994  CYS 994  1339 1339 CYS CYS A . n 
A 1 995  GLN 995  1340 1340 GLN GLN A . n 
A 1 996  LEU 996  1341 1341 LEU LEU A . n 
A 1 997  SER 997  1342 1342 SER SER A . n 
A 1 998  VAL 998  1343 1343 VAL VAL A . n 
A 1 999  VAL 999  1344 1344 VAL VAL A . n 
A 1 1000 VAL 1000 1345 1345 VAL VAL A . n 
A 1 1001 ASP 1001 1346 1346 ASP ASP A . n 
A 1 1002 ASP 1002 1347 1347 ASP ASP A . n 
A 1 1003 LYS 1003 1348 1348 LYS LYS A . n 
A 1 1004 LYS 1004 1349 1349 LYS LYS A . n 
A 1 1005 PHE 1005 1350 1350 PHE PHE A . n 
A 1 1006 VAL 1006 1351 1351 VAL VAL A . n 
A 1 1007 SER 1007 1352 1352 SER SER A . n 
A 1 1008 ASN 1008 1353 1353 ASN ASN A . n 
A 1 1009 ILE 1009 1354 1354 ILE ILE A . n 
A 1 1010 THR 1010 1355 1355 THR THR A . n 
A 1 1011 ARG 1011 1356 1356 ARG ARG A . n 
A 1 1012 LEU 1012 1357 1357 LEU LEU A . n 
A 1 1013 SER 1013 1358 1358 SER SER A . n 
A 1 1014 SER 1014 1359 1359 SER SER A . n 
A 1 1015 GLY 1015 1360 1360 GLY GLY A . n 
A 1 1016 PRO 1016 1361 1361 PRO PRO A . n 
A 1 1017 PHE 1017 1362 1362 PHE PHE A . n 
A 1 1018 ARG 1018 1363 1363 ARG ARG A . n 
A 1 1019 THR 1019 1364 1364 THR THR A . n 
A 1 1020 ILE 1020 1365 1365 ILE ILE A . n 
A 1 1021 THR 1021 1366 1366 THR THR A . n 
A 1 1022 VAL 1022 1367 1367 VAL VAL A . n 
A 1 1023 ARG 1023 1368 1368 ARG ARG A . n 
A 1 1024 ASP 1024 1369 1369 ASP ASP A . n 
A 1 1025 THR 1025 1370 1370 THR THR A . n 
A 1 1026 MET 1026 1371 1371 MET MET A . n 
A 1 1027 SER 1027 1372 1372 SER SER A . n 
A 1 1028 ASP 1028 1373 1373 ASP ASP A . n 
A 1 1029 LEU 1029 1374 1374 LEU LEU A . n 
A 1 1030 PRO 1030 1375 1375 PRO PRO A . n 
A 1 1031 GLU 1031 1376 1376 GLU GLU A . n 
A 1 1032 VAL 1032 1377 1377 VAL VAL A . n 
A 1 1033 ARG 1033 1378 1378 ARG ARG A . n 
A 1 1034 ASN 1034 1379 1379 ASN ASN A . n 
A 1 1035 GLY 1035 1380 1380 GLY GLY A . n 
A 1 1036 ALA 1036 1381 1381 ALA ALA A . n 
A 1 1037 SER 1037 1382 1382 SER SER A . n 
A 1 1038 ALA 1038 1383 1383 ALA ALA A . n 
A 1 1039 LEU 1039 1384 1384 LEU LEU A . n 
A 1 1040 GLU 1040 1385 1385 GLU GLU A . n 
A 1 1041 ILE 1041 1386 1386 ILE ILE A . n 
A 1 1042 SER 1042 1387 1387 SER SER A . n 
A 1 1043 TYR 1043 1388 1388 TYR TYR A . n 
A 1 1044 ASN 1044 1389 1389 ASN ASN A . n 
A 1 1045 GLY 1045 1390 1390 GLY GLY A . n 
A 1 1046 GLU 1046 1391 1391 GLU GLU A . n 
A 1 1047 PRO 1047 1392 1392 PRO PRO A . n 
A 1 1048 GLN 1048 1393 1393 GLN GLN A . n 
A 1 1049 SER 1049 1394 1394 SER SER A . n 
A 1 1050 TRP 1050 1395 1395 TRP TRP A . n 
A 1 1051 PHE 1051 1396 1396 PHE PHE A . n 
A 1 1052 GLN 1052 1397 1397 GLN GLN A . n 
A 1 1053 ARG 1053 1398 1398 ARG ARG A . n 
A 1 1054 GLN 1054 1399 1399 GLN GLN A . n 
A 1 1055 LEU 1055 1400 1400 LEU LEU A . n 
A 1 1056 ARG 1056 1401 1401 ARG ARG A . n 
A 1 1057 GLY 1057 1402 1402 GLY GLY A . n 
A 1 1058 ALA 1058 1403 1403 ALA ALA A . n 
A 1 1059 GLN 1059 1404 1404 GLN GLN A . n 
A 1 1060 TYR 1060 1405 1405 TYR TYR A . n 
A 1 1061 GLN 1061 1406 1406 GLN GLN A . n 
A 1 1062 PRO 1062 1407 1407 PRO PRO A . n 
A 1 1063 ILE 1063 1408 1408 ILE ILE A . n 
A 1 1064 LEU 1064 1409 1409 LEU LEU A . n 
A 1 1065 ARG 1065 1410 1410 ARG ARG A . n 
A 1 1066 ASP 1066 1411 1411 ASP ASP A . n 
A 1 1067 HIS 1067 1412 1412 HIS HIS A . n 
A 1 1068 ILE 1068 1413 1413 ILE ILE A . n 
A 1 1069 CYS 1069 1414 1414 CYS CYS A . n 
A 1 1070 LYS 1070 1415 1415 LYS LYS A . n 
A 1 1071 ASP 1071 1416 1416 ASP ASP A . n 
A 1 1072 MET 1072 1417 1417 MET MET A . n 
A 1 1073 SER 1073 1418 1418 SER SER A . n 
A 1 1074 ALA 1074 1419 1419 ALA ALA A . n 
A 1 1075 LEU 1075 1420 1420 LEU LEU A . n 
A 1 1076 VAL 1076 1421 1421 VAL VAL A . n 
A 1 1077 ALA 1077 1422 1422 ALA ALA A . n 
A 1 1078 ALA 1078 1423 1423 ALA ALA A . n 
A 1 1079 ARG 1079 1424 1424 ARG ARG A . n 
A 1 1080 MET 1080 1425 1425 MET MET A . n 
A 1 1081 ARG 1081 1426 1426 ARG ARG A . n 
A 1 1082 HIS 1082 1427 1427 HIS HIS A . n 
A 1 1083 ILE 1083 1428 1428 ILE ILE A . n 
A 1 1084 PRO 1084 1429 1429 PRO PRO A . n 
A 1 1085 LEU 1085 1430 1430 LEU LEU A . n 
A 1 1086 ALA 1086 1431 1431 ALA ALA A . n 
A 1 1087 PRO 1087 1432 1432 PRO PRO A . n 
A 1 1088 GLY 1088 1433 1433 GLY GLY A . n 
A 1 1089 SER 1089 1434 1434 SER SER A . n 
A 1 1090 ASP 1090 1435 1435 ASP ASP A . n 
A 1 1091 TRP 1091 1436 1436 TRP TRP A . n 
A 1 1092 ARG 1092 1437 1437 ARG ARG A . n 
A 1 1093 ASP 1093 1438 1438 ASP ASP A . n 
A 1 1094 LEU 1094 1439 1439 LEU LEU A . n 
A 1 1095 PRO 1095 1440 1440 PRO PRO A . n 
A 1 1096 ASN 1096 1441 1441 ASN ASN A . n 
A 1 1097 ILE 1097 1442 1442 ILE ILE A . n 
A 1 1098 GLU 1098 1443 1443 GLU GLU A . n 
A 1 1099 VAL 1099 1444 1444 VAL VAL A . n 
A 1 1100 ARG 1100 1445 1445 ARG ARG A . n 
A 1 1101 LEU 1101 1446 1446 LEU LEU A . n 
A 1 1102 SER 1102 1447 1447 SER SER A . n 
A 1 1103 ASP 1103 1448 1448 ASP ASP A . n 
A 1 1104 GLY 1104 1449 1449 GLY GLY A . n 
A 1 1105 THR 1105 1450 1450 THR THR A . n 
A 1 1106 MET 1106 1451 1451 MET MET A . n 
A 1 1107 ALA 1107 1452 1452 ALA ALA A . n 
A 1 1108 ARG 1108 1453 1453 ARG ARG A . n 
A 1 1109 LYS 1109 1454 1454 LYS LYS A . n 
A 1 1110 LEU 1110 1455 1455 LEU LEU A . n 
A 1 1111 ARG 1111 1456 1456 ARG ARG A . n 
A 1 1112 TYR 1112 1457 1457 TYR TYR A . n 
A 1 1113 THR 1113 1458 1458 THR THR A . n 
A 1 1114 HIS 1114 1459 1459 HIS HIS A . n 
A 1 1115 HIS 1115 1460 1460 HIS HIS A . n 
A 1 1116 ASP 1116 1461 1461 ASP ASP A . n 
A 1 1117 ARG 1117 1462 1462 ARG ARG A . n 
A 1 1118 LYS 1118 1463 1463 LYS LYS A . n 
A 1 1119 ASN 1119 1464 1464 ASN ASN A . n 
A 1 1120 GLY 1120 1465 1465 GLY GLY A . n 
A 1 1121 ARG 1121 1466 1466 ARG ARG A . n 
A 1 1122 SER 1122 1467 1467 SER SER A . n 
A 1 1123 SER 1123 1468 1468 SER SER A . n 
A 1 1124 SER 1124 1469 1469 SER SER A . n 
A 1 1125 GLY 1125 1470 1470 GLY GLY A . n 
A 1 1126 ALA 1126 1471 1471 ALA ALA A . n 
A 1 1127 LEU 1127 1472 1472 LEU LEU A . n 
A 1 1128 ARG 1128 1473 1473 ARG ARG A . n 
A 1 1129 GLY 1129 1474 1474 GLY GLY A . n 
A 1 1130 VAL 1130 1475 1475 VAL VAL A . n 
A 1 1131 CYS 1131 1476 1476 CYS CYS A . n 
A 1 1132 SER 1132 1477 1477 SER SER A . n 
A 1 1133 CYS 1133 1478 1478 CYS CYS A . n 
A 1 1134 VAL 1134 1479 1479 VAL VAL A . n 
A 1 1135 GLU 1135 1480 ?    ?   ?   A . n 
A 1 1136 ALA 1136 1481 ?    ?   ?   A . n 
A 1 1137 GLY 1137 1482 ?    ?   ?   A . n 
A 1 1138 LYS 1138 1483 ?    ?   ?   A . n 
A 1 1139 ALA 1139 1484 1484 ALA ALA A . n 
A 1 1140 CYS 1140 1485 1485 CYS CYS A . n 
A 1 1141 ASP 1141 1486 1486 ASP ASP A . n 
A 1 1142 PRO 1142 1487 1487 PRO PRO A . n 
A 1 1143 ALA 1143 1488 1488 ALA ALA A . n 
A 1 1144 ALA 1144 1489 1489 ALA ALA A . n 
A 1 1145 ARG 1145 1490 1490 ARG ARG A . n 
A 1 1146 GLN 1146 1491 1491 GLN GLN A . n 
A 1 1147 PHE 1147 1492 1492 PHE PHE A . n 
A 1 1148 ASN 1148 1493 1493 ASN ASN A . n 
A 1 1149 THR 1149 1494 1494 THR THR A . n 
A 1 1150 LEU 1150 1495 1495 LEU LEU A . n 
A 1 1151 ILE 1151 1496 1496 ILE ILE A . n 
A 1 1152 PRO 1152 1497 1497 PRO PRO A . n 
A 1 1153 TRP 1153 1498 1498 TRP TRP A . n 
A 1 1154 CYS 1154 1499 1499 CYS CYS A . n 
A 1 1155 LEU 1155 1500 1500 LEU LEU A . n 
A 1 1156 PRO 1156 1501 1501 PRO PRO A . n 
A 1 1157 HIS 1157 1502 1502 HIS HIS A . n 
A 1 1158 THR 1158 1503 1503 THR THR A . n 
A 1 1159 GLY 1159 1504 1504 GLY GLY A . n 
A 1 1160 ASN 1160 1505 1505 ASN ASN A . n 
A 1 1161 ARG 1161 1506 1506 ARG ARG A . n 
A 1 1162 HIS 1162 1507 1507 HIS HIS A . n 
A 1 1163 ASN 1163 1508 1508 ASN ASN A . n 
A 1 1164 HIS 1164 1509 1509 HIS HIS A . n 
A 1 1165 TRP 1165 1510 1510 TRP TRP A . n 
A 1 1166 ALA 1166 1511 1511 ALA ALA A . n 
A 1 1167 GLY 1167 1512 1512 GLY GLY A . n 
A 1 1168 LEU 1168 1513 1513 LEU LEU A . n 
A 1 1169 TYR 1169 1514 1514 TYR TYR A . n 
A 1 1170 GLY 1170 1515 1515 GLY GLY A . n 
A 1 1171 ARG 1171 1516 1516 ARG ARG A . n 
A 1 1172 LEU 1172 1517 1517 LEU LEU A . n 
A 1 1173 GLU 1173 1518 1518 GLU GLU A . n 
A 1 1174 TRP 1174 1519 1519 TRP TRP A . n 
A 1 1175 ASP 1175 1520 1520 ASP ASP A . n 
A 1 1176 GLY 1176 1521 1521 GLY GLY A . n 
A 1 1177 PHE 1177 1522 1522 PHE PHE A . n 
A 1 1178 PHE 1178 1523 1523 PHE PHE A . n 
A 1 1179 SER 1179 1524 1524 SER SER A . n 
A 1 1180 THR 1180 1525 1525 THR THR A . n 
A 1 1181 THR 1181 1526 1526 THR THR A . n 
A 1 1182 VAL 1182 1527 1527 VAL VAL A . n 
A 1 1183 THR 1183 1528 1528 THR THR A . n 
A 1 1184 ASN 1184 1529 1529 ASN ASN A . n 
A 1 1185 PRO 1185 1530 1530 PRO PRO A . n 
A 1 1186 GLU 1186 1531 1531 GLU GLU A . n 
A 1 1187 PRO 1187 1532 1532 PRO PRO A . n 
A 1 1188 MET 1188 1533 1533 MET MET A . n 
A 1 1189 GLY 1189 1534 1534 GLY GLY A . n 
A 1 1190 LYS 1190 1535 1535 LYS LYS A . n 
A 1 1191 GLN 1191 1536 1536 GLN GLN A . n 
A 1 1192 GLY 1192 1537 1537 GLY GLY A . n 
A 1 1193 ARG 1193 1538 1538 ARG ARG A . n 
A 1 1194 VAL 1194 1539 1539 VAL VAL A . n 
A 1 1195 LEU 1195 1540 1540 LEU LEU A . n 
A 1 1196 HIS 1196 1541 1541 HIS HIS A . n 
A 1 1197 PRO 1197 1542 1542 PRO PRO A . n 
A 1 1198 GLU 1198 1543 1543 GLU GLU A . n 
A 1 1199 GLN 1199 1544 1544 GLN GLN A . n 
A 1 1200 HIS 1200 1545 1545 HIS HIS A . n 
A 1 1201 ARG 1201 1546 1546 ARG ARG A . n 
A 1 1202 VAL 1202 1547 1547 VAL VAL A . n 
A 1 1203 VAL 1203 1548 1548 VAL VAL A . n 
A 1 1204 SER 1204 1549 1549 SER SER A . n 
A 1 1205 VAL 1205 1550 1550 VAL VAL A . n 
A 1 1206 ARG 1206 1551 1551 ARG ARG A . n 
A 1 1207 GLU 1207 1552 1552 GLU GLU A . n 
A 1 1208 CYS 1208 1553 1553 CYS CYS A . n 
A 1 1209 ALA 1209 1554 1554 ALA ALA A . n 
A 1 1210 ARG 1210 1555 1555 ARG ARG A . n 
A 1 1211 SER 1211 1556 1556 SER SER A . n 
A 1 1212 GLN 1212 1557 1557 GLN GLN A . n 
A 1 1213 GLY 1213 1558 1558 GLY GLY A . n 
A 1 1214 PHE 1214 1559 1559 PHE PHE A . n 
A 1 1215 PRO 1215 1560 1560 PRO PRO A . n 
A 1 1216 ASP 1216 1561 1561 ASP ASP A . n 
A 1 1217 THR 1217 1562 1562 THR THR A . n 
A 1 1218 TYR 1218 1563 1563 TYR TYR A . n 
A 1 1219 ARG 1219 1564 1564 ARG ARG A . n 
A 1 1220 LEU 1220 1565 1565 LEU LEU A . n 
A 1 1221 PHE 1221 1566 1566 PHE PHE A . n 
A 1 1222 GLY 1222 1567 1567 GLY GLY A . n 
A 1 1223 ASN 1223 1568 1568 ASN ASN A . n 
A 1 1224 ILE 1224 1569 1569 ILE ILE A . n 
A 1 1225 LEU 1225 1570 1570 LEU LEU A . n 
A 1 1226 ASP 1226 1571 1571 ASP ASP A . n 
A 1 1227 LYS 1227 1572 1572 LYS LYS A . n 
A 1 1228 HIS 1228 1573 1573 HIS HIS A . n 
A 1 1229 ARG 1229 1574 1574 ARG ARG A . n 
A 1 1230 GLN 1230 1575 1575 GLN GLN A . n 
A 1 1231 VAL 1231 1576 1576 VAL VAL A . n 
A 1 1232 GLY 1232 1577 1577 GLY GLY A . n 
A 1 1233 ASN 1233 1578 1578 ASN ASN A . n 
A 1 1234 ALA 1234 1579 1579 ALA ALA A . n 
A 1 1235 VAL 1235 1580 1580 VAL VAL A . n 
A 1 1236 PRO 1236 1581 1581 PRO PRO A . n 
A 1 1237 PRO 1237 1582 1582 PRO PRO A . n 
A 1 1238 PRO 1238 1583 1583 PRO PRO A . n 
A 1 1239 LEU 1239 1584 1584 LEU LEU A . n 
A 1 1240 ALA 1240 1585 1585 ALA ALA A . n 
A 1 1241 LYS 1241 1586 1586 LYS LYS A . n 
A 1 1242 ALA 1242 1587 1587 ALA ALA A . n 
A 1 1243 ILE 1243 1588 1588 ILE ILE A . n 
A 1 1244 GLY 1244 1589 1589 GLY GLY A . n 
A 1 1245 LEU 1245 1590 1590 LEU LEU A . n 
A 1 1246 GLU 1246 1591 1591 GLU GLU A . n 
A 1 1247 ILE 1247 1592 1592 ILE ILE A . n 
A 1 1248 LYS 1248 1593 1593 LYS LYS A . n 
A 1 1249 LEU 1249 1594 1594 LEU LEU A . n 
A 1 1250 CYS 1250 1595 1595 CYS CYS A . n 
A 1 1251 MET 1251 1596 1596 MET MET A . n 
A 1 1252 LEU 1252 1597 1597 LEU LEU A . n 
A 1 1253 ALA 1253 1598 1598 ALA ALA A . n 
A 1 1254 LYS 1254 1599 1599 LYS LYS A . n 
A 1 1255 ALA 1255 1600 1600 ALA ALA A . n 
A 1 1256 ARG 1256 1601 1601 ARG ARG A . n 
A 1 1257 GLU 1257 1602 1602 GLU GLU A . n 
A 1 1258 SER 1258 1603 1603 SER SER A . n 
A 1 1259 ALA 1259 1604 1604 ALA ALA A . n 
A 1 1260 SER 1260 1605 1605 SER SER A . n 
A 1 1261 ALA 1261 1606 ?    ?   ?   A . n 
A 1 1262 LYS 1262 1607 ?    ?   ?   A . n 
A 1 1263 ILE 1263 1608 ?    ?   ?   A . n 
A 1 1264 LYS 1264 1609 ?    ?   ?   A . n 
A 1 1265 GLU 1265 1610 ?    ?   ?   A . n 
A 1 1266 GLU 1266 1611 ?    ?   ?   A . n 
A 1 1267 GLU 1267 1612 ?    ?   ?   A . n 
A 1 1268 ALA 1268 1613 ?    ?   ?   A . n 
A 1 1269 ALA 1269 1614 ?    ?   ?   A . n 
A 1 1270 LYS 1270 1615 ?    ?   ?   A . n 
A 1 1271 ASP 1271 1616 ?    ?   ?   A . n 
B 2 1    DA  1    1    1    DA  DA  B . n 
B 2 2    DC  2    2    2    DC  DC  B . n 
B 2 3    DT  3    3    3    DT  DT  B . n 
B 2 4    DT  4    4    4    DT  DT  B . n 
B 2 5    DA  5    5    5    DA  DA  B . n 
B 2 6    5CM 6    6    6    5CM 5CM B . n 
B 2 7    DG  7    7    7    DG  DG  B . n 
B 2 8    DG  8    8    8    DG  DG  B . n 
B 2 9    DA  9    9    9    DA  DA  B . n 
B 2 10   DA  10   10   10   DA  DA  B . n 
B 2 11   DG  11   11   11   DG  DG  B . n 
B 2 12   DG  12   12   12   DG  DG  B . n 
C 3 1    DC  1    1    1    DC  DC  C . n 
C 3 2    DC  2    2    2    DC  DC  C . n 
C 3 3    DT  3    3    3    DT  DT  C . n 
C 3 4    DT  4    4    4    DT  DT  C . n 
C 3 5    DC  5    5    5    DC  DC  C . n 
C 3 6    EIX 6    6    6    EIX C55 C . n 
C 3 7    DG  7    7    7    DG  DG  C . n 
C 3 8    DT  8    8    8    DT  DT  C . n 
C 3 9    DA  9    9    9    DA  DA  C . n 
C 3 10   DA  10   10   10   DA  DA  C . n 
C 3 11   DG  11   11   11   DG  DG  C . n 
C 3 12   DT  12   12   12   DT  DT  C . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 5CM ? ? 5CM ? ? 'SUBJECT OF INVESTIGATION' ? 
2 EIX ? ? EIX ? ? 'SUBJECT OF INVESTIGATION' ? 
3 SAH ? ? SAH ? ? 'SUBJECT OF INVESTIGATION' ? 
4 ZN  ? ? ZN  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 SAH 1 1701 1 SAH SAH A . 
E 5 ZN  1 1702 1 ZN  ZN  A . 
F 5 ZN  1 1703 2 ZN  ZN  A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A LYS 744 ? CG ? A LYS 399 CG 
2 1 Y 1 A LYS 744 ? CD ? A LYS 399 CD 
3 1 Y 1 A LYS 744 ? CE ? A LYS 399 CE 
4 1 Y 1 A LYS 744 ? NZ ? A LYS 399 NZ 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XQC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XQC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XQC 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8XQC 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004  ? 7457  ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.590  ? 10192 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 16.415 ? 1176  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.041  ? 1084  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005  ? 1240  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8XQC 
_struct.title                        
'Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XQC 
_struct_keywords.text            'DNA methyltransferase, protein-DNA complex, replication factor, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP DNMT1_HUMAN P26358 ? 1 
;PKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKN
IELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISK
IVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGV
TLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKAC
KDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKV
CIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHS
KVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRV
LEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEP
YRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPE
CVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVFSGCGG
LSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFS
GMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTR
RRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNG
EPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSG
ALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSV
RECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
;
351 
2 PDB 8XQC        8XQC   ? 2 ? 1   
3 PDB 8XQC        8XQC   ? 3 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XQC A 6 ? 1271 ? P26358 351 ? 1616 ? 351 1616 
2 2 8XQC B 1 ? 12   ? 8XQC   1   ? 12   ? 1   12   
3 3 8XQC C 1 ? 12   ? 8XQC   1   ? 12   ? 1   12   
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8XQC GLY A 1 ? UNP P26358 ? ? 'expression tag' 346 1 
1 8XQC PRO A 2 ? UNP P26358 ? ? 'expression tag' 347 2 
1 8XQC PRO A 3 ? UNP P26358 ? ? 'expression tag' 348 3 
1 8XQC THR A 4 ? UNP P26358 ? ? 'expression tag' 349 4 
1 8XQC THR A 5 ? UNP P26358 ? ? 'expression tag' 350 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 276  ? PHE A 283  ? THR A 621  PHE A 628  1 ? 8  
HELX_P HELX_P2  AA2 LEU A 460  ? SER A 464  ? LEU A 805  SER A 809  5 ? 5  
HELX_P HELX_P3  AA3 ASN A 497  ? GLU A 501  ? ASN A 842  GLU A 846  5 ? 5  
HELX_P HELX_P4  AA4 CYS A 548  ? ILE A 562  ? CYS A 893  ILE A 907  1 ? 15 
HELX_P HELX_P5  AA5 GLU A 626  ? LYS A 630  ? GLU A 971  LYS A 975  5 ? 5  
HELX_P HELX_P6  AA6 ARG A 678  ? THR A 682  ? ARG A 1023 THR A 1027 5 ? 5  
HELX_P HELX_P7  AA7 SER A 685  ? SER A 689  ? SER A 1030 SER A 1034 5 ? 5  
HELX_P HELX_P8  AA8 LYS A 709  ? VAL A 711  ? LYS A 1054 VAL A 1056 5 ? 3  
HELX_P HELX_P9  AA9 CYS A 726  ? MET A 732  ? CYS A 1071 MET A 1077 1 ? 7  
HELX_P HELX_P10 AB1 PRO A 755  ? SER A 760  ? PRO A 1100 SER A 1105 1 ? 6  
HELX_P HELX_P11 AB2 GLY A 804  ? GLY A 814  ? GLY A 1149 GLY A 1159 1 ? 11 
HELX_P HELX_P12 AB3 TRP A 825  ? ASN A 836  ? TRP A 1170 ASN A 1181 1 ? 12 
HELX_P HELX_P13 AB4 ASP A 845  ? ALA A 855  ? ASP A 1190 ALA A 1200 1 ? 11 
HELX_P HELX_P14 AB5 ARG A 893  ? SER A 901  ? ARG A 1238 SER A 1246 1 ? 9  
HELX_P HELX_P15 AB6 SER A 901  ? ARG A 914  ? SER A 1246 ARG A 1259 1 ? 14 
HELX_P HELX_P16 AB7 ASN A 925  ? PHE A 929  ? ASN A 1270 PHE A 1274 5 ? 5  
HELX_P HELX_P17 AB8 SER A 932  ? GLY A 946  ? SER A 1277 GLY A 1291 1 ? 15 
HELX_P HELX_P18 AB9 GLY A 957  ? TYR A 959  ? GLY A 1302 TYR A 1304 5 ? 3  
HELX_P HELX_P19 AC1 THR A 1021 ? SER A 1027 ? THR A 1366 SER A 1372 1 ? 7  
HELX_P HELX_P20 AC2 SER A 1049 ? GLY A 1057 ? SER A 1394 GLY A 1402 1 ? 9  
HELX_P HELX_P21 AC3 SER A 1073 ? HIS A 1082 ? SER A 1418 HIS A 1427 1 ? 10 
HELX_P HELX_P22 AC4 ASP A 1090 ? LEU A 1094 ? ASP A 1435 LEU A 1439 5 ? 5  
HELX_P HELX_P23 AC5 TRP A 1153 ? GLY A 1159 ? TRP A 1498 GLY A 1504 1 ? 7  
HELX_P HELX_P24 AC6 HIS A 1162 ? ALA A 1166 ? HIS A 1507 ALA A 1511 5 ? 5  
HELX_P HELX_P25 AC7 SER A 1204 ? GLN A 1212 ? SER A 1549 GLN A 1557 1 ? 9  
HELX_P HELX_P26 AC8 ASN A 1223 ? ASN A 1233 ? ASN A 1568 ASN A 1578 1 ? 11 
HELX_P HELX_P27 AC9 PRO A 1236 ? SER A 1260 ? PRO A 1581 SER A 1605 1 ? 25 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale none ? A CYS 881  CB    ? ? ? 1_555 C EIX 6  SG ? ? A CYS 1226 C EIX 6    1_555 ? ? ? ? ? ? ?            1.766 ? ? 
covale2  covale both ? B DA  5    "O3'" ? ? ? 1_555 B 5CM 6  P  ? ? B DA  5    B 5CM 6    1_555 ? ? ? ? ? ? ?            1.602 ? ? 
covale3  covale both ? B 5CM 6    "O3'" ? ? ? 1_555 B DG  7  P  ? ? B 5CM 6    B DG  7    1_555 ? ? ? ? ? ? ?            1.606 ? ? 
covale4  covale both ? C DC  5    "O3'" ? ? ? 1_555 C EIX 6  P  ? ? C DC  5    C EIX 6    1_555 ? ? ? ? ? ? ?            1.607 ? ? 
covale5  covale one  ? C EIX 6    "O3'" ? ? ? 1_555 C DG  7  P  ? ? C EIX 6    C DG  7    1_555 ? ? ? ? ? ? ?            1.606 ? ? 
metalc1  metalc ?    ? A HIS 448  NE2   ? ? ? 1_555 F ZN  .  ZN ? ? A HIS 793  A ZN  1703 1_555 ? ? ? ? ? ? ?            2.073 ? ? 
metalc2  metalc ?    ? A CYS 475  SG    ? ? ? 1_555 F ZN  .  ZN ? ? A CYS 820  A ZN  1703 1_555 ? ? ? ? ? ? ?            2.311 ? ? 
metalc3  metalc ?    ? A CYS 548  SG    ? ? ? 1_555 F ZN  .  ZN ? ? A CYS 893  A ZN  1703 1_555 ? ? ? ? ? ? ?            2.316 ? ? 
metalc4  metalc ?    ? A CYS 551  SG    ? ? ? 1_555 F ZN  .  ZN ? ? A CYS 896  A ZN  1703 1_555 ? ? ? ? ? ? ?            2.318 ? ? 
metalc5  metalc ?    ? A CYS 1131 SG    ? ? ? 1_555 E ZN  .  ZN ? ? A CYS 1476 A ZN  1702 1_555 ? ? ? ? ? ? ?            2.318 ? ? 
metalc6  metalc ?    ? A CYS 1133 SG    ? ? ? 1_555 E ZN  .  ZN ? ? A CYS 1478 A ZN  1702 1_555 ? ? ? ? ? ? ?            2.317 ? ? 
metalc7  metalc ?    ? A CYS 1140 SG    ? ? ? 1_555 E ZN  .  ZN ? ? A CYS 1485 A ZN  1702 1_555 ? ? ? ? ? ? ?            2.320 ? ? 
metalc8  metalc ?    ? A HIS 1157 NE2   ? ? ? 1_555 E ZN  .  ZN ? ? A HIS 1502 A ZN  1702 1_555 ? ? ? ? ? ? ?            2.055 ? ? 
hydrog1  hydrog ?    ? B DC  2    N3    ? ? ? 1_555 C DG  11 N1 ? ? B DC  2    C DG  11   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog2  hydrog ?    ? B DC  2    N4    ? ? ? 1_555 C DG  11 O6 ? ? B DC  2    C DG  11   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ?    ? B DC  2    O2    ? ? ? 1_555 C DG  11 N2 ? ? B DC  2    C DG  11   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ?    ? B DT  3    N3    ? ? ? 1_555 C DA  10 N1 ? ? B DT  3    C DA  10   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ?    ? B DT  3    O4    ? ? ? 1_555 C DA  10 N6 ? ? B DT  3    C DA  10   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ?    ? B DT  4    N3    ? ? ? 1_555 C DA  9  N1 ? ? B DT  4    C DA  9    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ?    ? B DT  4    O4    ? ? ? 1_555 C DA  9  N6 ? ? B DT  4    C DA  9    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ?    ? B DA  5    N1    ? ? ? 1_555 C DT  8  N3 ? ? B DA  5    C DT  8    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ?    ? B DA  5    N6    ? ? ? 1_555 C DT  8  O4 ? ? B DA  5    C DT  8    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ?    ? B 5CM 6    N3    ? ? ? 1_555 C DG  7  N1 ? ? B 5CM 6    C DG  7    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ?    ? B 5CM 6    N4    ? ? ? 1_555 C DG  7  O6 ? ? B 5CM 6    C DG  7    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ?    ? B 5CM 6    O2    ? ? ? 1_555 C DG  7  N2 ? ? B 5CM 6    C DG  7    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ?    ? B DA  9    N1    ? ? ? 1_555 C DT  4  N3 ? ? B DA  9    C DT  4    1_555 ? ? ? ? ? ? 'DA-DT PAIR' ?     ? ? 
hydrog14 hydrog ?    ? B DA  10   N1    ? ? ? 1_555 C DT  3  N3 ? ? B DA  10   C DT  3    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ?    ? B DA  10   N6    ? ? ? 1_555 C DT  3  O4 ? ? B DA  10   C DT  3    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ?    ? B DG  11   N1    ? ? ? 1_555 C DC  2  N3 ? ? B DG  11   C DC  2    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog17 hydrog ?    ? B DG  11   N2    ? ? ? 1_555 C DC  2  O2 ? ? B DG  11   C DC  2    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog18 hydrog ?    ? B DG  11   O6    ? ? ? 1_555 C DC  2  N4 ? ? B DG  11   C DC  2    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog19 hydrog ?    ? B DG  12   N1    ? ? ? 1_555 C DC  1  N3 ? ? B DG  12   C DC  1    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog20 hydrog ?    ? B DG  12   N2    ? ? ? 1_555 C DC  1  O2 ? ? B DG  12   C DC  1    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog21 hydrog ?    ? B DG  12   O6    ? ? ? 1_555 C DC  1  N4 ? ? B DG  12   C DC  1    1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
hydrog ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 448  ? A HIS 793  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 475  ? A CYS 820  ? 1_555 116.2 ? 
2  NE2 ? A HIS 448  ? A HIS 793  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 548  ? A CYS 893  ? 1_555 101.1 ? 
3  SG  ? A CYS 475  ? A CYS 820  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 548  ? A CYS 893  ? 1_555 110.4 ? 
4  NE2 ? A HIS 448  ? A HIS 793  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 551  ? A CYS 896  ? 1_555 104.8 ? 
5  SG  ? A CYS 475  ? A CYS 820  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 551  ? A CYS 896  ? 1_555 110.6 ? 
6  SG  ? A CYS 548  ? A CYS 893  ? 1_555 ZN ? F ZN . ? A ZN 1703 ? 1_555 SG  ? A CYS 551  ? A CYS 896  ? 1_555 113.5 ? 
7  SG  ? A CYS 1131 ? A CYS 1476 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 SG  ? A CYS 1133 ? A CYS 1478 ? 1_555 112.8 ? 
8  SG  ? A CYS 1131 ? A CYS 1476 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 SG  ? A CYS 1140 ? A CYS 1485 ? 1_555 114.2 ? 
9  SG  ? A CYS 1133 ? A CYS 1478 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 SG  ? A CYS 1140 ? A CYS 1485 ? 1_555 112.4 ? 
10 SG  ? A CYS 1131 ? A CYS 1476 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 NE2 ? A HIS 1157 ? A HIS 1502 ? 1_555 131.2 ? 
11 SG  ? A CYS 1133 ? A CYS 1478 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 NE2 ? A HIS 1157 ? A HIS 1502 ? 1_555 58.1  ? 
12 SG  ? A CYS 1140 ? A CYS 1485 ? 1_555 ZN ? E ZN . ? A ZN 1702 ? 1_555 NE2 ? A HIS 1157 ? A HIS 1502 ? 1_555 112.8 ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      EIX 
_pdbx_modification_feature.label_asym_id                      C 
_pdbx_modification_feature.label_seq_id                       6 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      881 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       EIX 
_pdbx_modification_feature.auth_asym_id                       C 
_pdbx_modification_feature.auth_seq_id                        6 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       1226 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   CB 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        EIX 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2  ? 
AA2 ? 2  ? 
AA3 ? 8  ? 
AA4 ? 10 ? 
AA5 ? 7  ? 
AA6 ? 2  ? 
AA7 ? 2  ? 
AA8 ? 2  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA2 1 2  ? anti-parallel 
AA3 1 2  ? anti-parallel 
AA3 1 5  ? anti-parallel 
AA3 2 3  ? anti-parallel 
AA3 3 4  ? anti-parallel 
AA3 4 7  ? parallel      
AA3 6 7  ? parallel      
AA3 7 8  ? anti-parallel 
AA4 1 2  ? anti-parallel 
AA4 2 3  ? anti-parallel 
AA4 2 5  ? anti-parallel 
AA4 4 5  ? anti-parallel 
AA4 4 8  ? anti-parallel 
AA4 5 6  ? anti-parallel 
AA4 6 7  ? anti-parallel 
AA4 7 9  ? parallel      
AA4 8 9  ? parallel      
AA4 9 10 ? anti-parallel 
AA5 1 2  ? parallel      
AA5 2 3  ? parallel      
AA5 3 4  ? parallel      
AA5 4 5  ? parallel      
AA5 5 6  ? anti-parallel 
AA5 6 7  ? anti-parallel 
AA6 1 2  ? anti-parallel 
AA7 1 2  ? anti-parallel 
AA8 1 2  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ALA A 273  ? THR A 274  ? ALA A 618  THR A 619  
AA1 2  ILE A 291  ? GLU A 292  ? ILE A 636  GLU A 637  
AA2 1  CYS A 406  ? ILE A 407  ? CYS A 751  ILE A 752  
AA2 2  THR A 411  ? LEU A 412  ? THR A 756  LEU A 757  
AA3 1  CYS A 417  ? VAL A 420  ? CYS A 762  VAL A 765  
AA3 2  TYR A 430  ? ASP A 440  ? TYR A 775  ASP A 785  
AA3 3  GLY A 444  ? ALA A 454  ? GLY A 789  ALA A 799  
AA3 4  GLU A 468  ? GLN A 479  ? GLU A 813  GLN A 824  
AA3 5  ILE A 483  ? LYS A 486  ? ILE A 828  LYS A 831  
AA3 6  VAL A 489  ? TYR A 491  ? VAL A 834  TYR A 836  
AA3 7  TYR A 518  ? ASP A 525  ? TYR A 863  ASP A 870  
AA3 8  ARG A 530  ? GLU A 532  ? ARG A 875  GLU A 877  
AA4 1  ARG A 564  ? ASP A 571  ? ARG A 909  ASP A 916  
AA4 2  ARG A 575  ? LYS A 583  ? ARG A 920  LYS A 928  
AA4 3  ILE A 586  ? ARG A 589  ? ILE A 931  ARG A 934  
AA4 4  GLY A 593  ? LEU A 596  ? GLY A 938  LEU A 941  
AA4 5  ARG A 647  ? PRO A 657  ? ARG A 992  PRO A 1002 
AA4 6  LYS A 670  ? TYR A 677  ? LYS A 1015 TYR A 1022 
AA4 7  LEU A 696  ? ASP A 707  ? LEU A 1041 ASP A 1052 
AA4 8  ARG A 714  ? TYR A 719  ? ARG A 1059 TYR A 1064 
AA4 9  ARG A 737  ? ASN A 745  ? ARG A 1082 ASN A 1090 
AA4 10 SER A 750  ? GLU A 752  ? SER A 1095 GLU A 1097 
AA5 1  THR A 840  ? PHE A 842  ? THR A 1185 PHE A 1187 
AA5 2  SER A 816  ? ILE A 822  ? SER A 1161 ILE A 1167 
AA5 3  LEU A 794  ? VAL A 799  ? LEU A 1139 VAL A 1144 
AA5 4  MET A 874  ? GLY A 877  ? MET A 1219 GLY A 1222 
AA5 5  PHE A 917  ? VAL A 923  ? PHE A 1262 VAL A 1268 
AA5 6  ARG A 966  ? ALA A 973  ? ARG A 1311 ALA A 1318 
AA5 7  GLN A 948  ? GLN A 955  ? GLN A 1293 GLN A 1300 
AA6 1  VAL A 998  ? VAL A 1000 ? VAL A 1343 VAL A 1345 
AA6 2  LYS A 1003 ? PHE A 1005 ? LYS A 1348 PHE A 1350 
AA7 1  ILE A 1041 ? SER A 1042 ? ILE A 1386 SER A 1387 
AA7 2  ILE A 1063 ? LEU A 1064 ? ILE A 1408 LEU A 1409 
AA8 1  VAL A 1099 ? ARG A 1100 ? VAL A 1444 ARG A 1445 
AA8 2  MET A 1106 ? ALA A 1107 ? MET A 1451 ALA A 1452 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ALA A 273  ? N ALA A 618  O GLU A 292  ? O GLU A 637  
AA2 1 2  N CYS A 406  ? N CYS A 751  O LEU A 412  ? O LEU A 757  
AA3 1 2  N VAL A 420  ? N VAL A 765  O TYR A 430  ? O TYR A 775  
AA3 1 5  N SER A 419  ? N SER A 764  O HIS A 484  ? O HIS A 829  
AA3 2 3  N ASP A 440  ? N ASP A 785  O GLY A 444  ? O GLY A 789  
AA3 3 4  N TRP A 451  ? N TRP A 796  O GLU A 474  ? O GLU A 819  
AA3 4 7  N LEU A 471  ? N LEU A 816  O TYR A 524  ? O TYR A 869  
AA3 6 7  N ILE A 490  ? N ILE A 835  O TYR A 518  ? O TYR A 863  
AA3 7 8  N TRP A 523  ? N TRP A 868  O GLU A 532  ? O GLU A 877  
AA4 1 2  N GLU A 570  ? N GLU A 915  O LEU A 577  ? O LEU A 922  
AA4 2 3  N LYS A 583  ? N LYS A 928  O ILE A 586  ? O ILE A 931  
AA4 2 5  N TYR A 578  ? N TYR A 923  O ILE A 654  ? O ILE A 999  
AA4 4 5  N LEU A 596  ? N LEU A 941  O ARG A 647  ? O ARG A 992  
AA4 4 8  N GLY A 593  ? N GLY A 938  O CYS A 715  ? O CYS A 1060 
AA4 5 6  N LYS A 652  ? N LYS A 997  O ARG A 672  ? O ARG A 1017 
AA4 6 7  N ILE A 671  ? N ILE A 1016 O VAL A 706  ? O VAL A 1051 
AA4 7 9  N TRP A 699  ? N TRP A 1044 O TYR A 744  ? O TYR A 1089 
AA4 8 9  N GLU A 718  ? N GLU A 1063 O PHE A 738  ? O PHE A 1083 
AA4 9 10 N ASN A 745  ? N ASN A 1090 O SER A 750  ? O SER A 1095 
AA5 1 2  O PHE A 842  ? O PHE A 1187 N ALA A 821  ? N ALA A 1166 
AA5 2 3  O ASP A 817  ? O ASP A 1162 N THR A 796  ? N THR A 1141 
AA5 3 4  N LEU A 797  ? N LEU A 1142 O MET A 874  ? O MET A 1219 
AA5 4 5  N LEU A 875  ? N LEU A 1220 O PHE A 917  ? O PHE A 1262 
AA5 5 6  N LEU A 920  ? N LEU A 1265 O ILE A 970  ? O ILE A 1315 
AA5 6 7  O ARG A 967  ? O ARG A 1312 N LEU A 954  ? N LEU A 1299 
AA6 1 2  N VAL A 998  ? N VAL A 1343 O PHE A 1005 ? O PHE A 1350 
AA7 1 2  N ILE A 1041 ? N ILE A 1386 O LEU A 1064 ? O LEU A 1409 
AA8 1 2  N VAL A 1099 ? N VAL A 1444 O ALA A 1107 ? O ALA A 1452 
# 
_pdbx_entry_details.entry_id                   8XQC 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   SG 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   CYS 
_pdbx_validate_close_contact.auth_seq_id_1    1478 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   NE2 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HIS 
_pdbx_validate_close_contact.auth_seq_id_2    1502 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.13 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 753  ? ? -98.86  57.14   
2  1 ALA A 754  ? ? 66.64   -1.66   
3  1 ASP A 818  ? ? -95.07  58.39   
4  1 LYS A 975  ? ? -91.88  53.77   
5  1 SER A 1030 ? ? -77.90  -162.33 
6  1 THR A 1031 ? ? -38.34  -37.59  
7  1 SER A 1105 ? ? 58.07   70.18   
8  1 GLU A 1168 ? ? -164.63 118.06  
9  1 THR A 1203 ? ? 47.62   18.59   
10 1 HIS A 1412 ? ? -101.13 77.20   
11 1 HIS A 1507 ? ? -140.84 30.82   
12 1 HIS A 1509 ? ? 57.44   18.84   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8XQC 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8XQC 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.25 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               356895 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 
'Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog' ? ? ? 1,2,3 
2 1 RECOMBINANT        COMPLEX DNMT1 ? ? ? 1     
3 1 SYNTHETIC          COMPLEX DNA ? ? ? 2,3   
# 
_em_imaging.entry_id                        8XQC 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8XQC 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8XQC 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 346  ? A GLY 1    
2   1 Y 1 A PRO 347  ? A PRO 2    
3   1 Y 1 A PRO 348  ? A PRO 3    
4   1 Y 1 A THR 349  ? A THR 4    
5   1 Y 1 A THR 350  ? A THR 5    
6   1 Y 1 A PRO 351  ? A PRO 6    
7   1 Y 1 A LYS 352  ? A LYS 7    
8   1 Y 1 A CYS 353  ? A CYS 8    
9   1 Y 1 A ILE 354  ? A ILE 9    
10  1 Y 1 A GLN 355  ? A GLN 10   
11  1 Y 1 A CYS 356  ? A CYS 11   
12  1 Y 1 A GLY 357  ? A GLY 12   
13  1 Y 1 A GLN 358  ? A GLN 13   
14  1 Y 1 A TYR 359  ? A TYR 14   
15  1 Y 1 A LEU 360  ? A LEU 15   
16  1 Y 1 A ASP 361  ? A ASP 16   
17  1 Y 1 A ASP 362  ? A ASP 17   
18  1 Y 1 A PRO 363  ? A PRO 18   
19  1 Y 1 A ASP 364  ? A ASP 19   
20  1 Y 1 A LEU 365  ? A LEU 20   
21  1 Y 1 A LYS 366  ? A LYS 21   
22  1 Y 1 A TYR 367  ? A TYR 22   
23  1 Y 1 A GLY 368  ? A GLY 23   
24  1 Y 1 A GLN 369  ? A GLN 24   
25  1 Y 1 A HIS 370  ? A HIS 25   
26  1 Y 1 A PRO 371  ? A PRO 26   
27  1 Y 1 A PRO 372  ? A PRO 27   
28  1 Y 1 A ASP 373  ? A ASP 28   
29  1 Y 1 A ALA 374  ? A ALA 29   
30  1 Y 1 A VAL 375  ? A VAL 30   
31  1 Y 1 A ASP 376  ? A ASP 31   
32  1 Y 1 A GLU 377  ? A GLU 32   
33  1 Y 1 A PRO 378  ? A PRO 33   
34  1 Y 1 A GLN 379  ? A GLN 34   
35  1 Y 1 A MET 380  ? A MET 35   
36  1 Y 1 A LEU 381  ? A LEU 36   
37  1 Y 1 A THR 382  ? A THR 37   
38  1 Y 1 A ASN 383  ? A ASN 38   
39  1 Y 1 A GLU 384  ? A GLU 39   
40  1 Y 1 A LYS 385  ? A LYS 40   
41  1 Y 1 A LEU 386  ? A LEU 41   
42  1 Y 1 A SER 387  ? A SER 42   
43  1 Y 1 A ILE 388  ? A ILE 43   
44  1 Y 1 A PHE 389  ? A PHE 44   
45  1 Y 1 A ASP 390  ? A ASP 45   
46  1 Y 1 A ALA 391  ? A ALA 46   
47  1 Y 1 A ASN 392  ? A ASN 47   
48  1 Y 1 A GLU 393  ? A GLU 48   
49  1 Y 1 A SER 394  ? A SER 49   
50  1 Y 1 A GLY 395  ? A GLY 50   
51  1 Y 1 A PHE 396  ? A PHE 51   
52  1 Y 1 A GLU 397  ? A GLU 52   
53  1 Y 1 A SER 398  ? A SER 53   
54  1 Y 1 A TYR 399  ? A TYR 54   
55  1 Y 1 A GLU 400  ? A GLU 55   
56  1 Y 1 A ALA 401  ? A ALA 56   
57  1 Y 1 A LEU 402  ? A LEU 57   
58  1 Y 1 A PRO 403  ? A PRO 58   
59  1 Y 1 A GLN 404  ? A GLN 59   
60  1 Y 1 A HIS 405  ? A HIS 60   
61  1 Y 1 A LYS 406  ? A LYS 61   
62  1 Y 1 A LEU 407  ? A LEU 62   
63  1 Y 1 A THR 408  ? A THR 63   
64  1 Y 1 A CYS 409  ? A CYS 64   
65  1 Y 1 A PHE 410  ? A PHE 65   
66  1 Y 1 A SER 411  ? A SER 66   
67  1 Y 1 A VAL 412  ? A VAL 67   
68  1 Y 1 A TYR 413  ? A TYR 68   
69  1 Y 1 A CYS 414  ? A CYS 69   
70  1 Y 1 A LYS 415  ? A LYS 70   
71  1 Y 1 A HIS 416  ? A HIS 71   
72  1 Y 1 A GLY 417  ? A GLY 72   
73  1 Y 1 A HIS 418  ? A HIS 73   
74  1 Y 1 A LEU 419  ? A LEU 74   
75  1 Y 1 A CYS 420  ? A CYS 75   
76  1 Y 1 A PRO 421  ? A PRO 76   
77  1 Y 1 A ILE 422  ? A ILE 77   
78  1 Y 1 A ASP 423  ? A ASP 78   
79  1 Y 1 A THR 424  ? A THR 79   
80  1 Y 1 A GLY 425  ? A GLY 80   
81  1 Y 1 A LEU 426  ? A LEU 81   
82  1 Y 1 A ILE 427  ? A ILE 82   
83  1 Y 1 A GLU 428  ? A GLU 83   
84  1 Y 1 A LYS 429  ? A LYS 84   
85  1 Y 1 A ASN 430  ? A ASN 85   
86  1 Y 1 A ILE 431  ? A ILE 86   
87  1 Y 1 A GLU 432  ? A GLU 87   
88  1 Y 1 A LEU 433  ? A LEU 88   
89  1 Y 1 A PHE 434  ? A PHE 89   
90  1 Y 1 A PHE 435  ? A PHE 90   
91  1 Y 1 A SER 436  ? A SER 91   
92  1 Y 1 A GLY 437  ? A GLY 92   
93  1 Y 1 A SER 438  ? A SER 93   
94  1 Y 1 A ALA 439  ? A ALA 94   
95  1 Y 1 A LYS 440  ? A LYS 95   
96  1 Y 1 A PRO 441  ? A PRO 96   
97  1 Y 1 A ILE 442  ? A ILE 97   
98  1 Y 1 A TYR 443  ? A TYR 98   
99  1 Y 1 A ASP 444  ? A ASP 99   
100 1 Y 1 A ASP 445  ? A ASP 100  
101 1 Y 1 A ASP 446  ? A ASP 101  
102 1 Y 1 A PRO 447  ? A PRO 102  
103 1 Y 1 A SER 448  ? A SER 103  
104 1 Y 1 A LEU 449  ? A LEU 104  
105 1 Y 1 A GLU 450  ? A GLU 105  
106 1 Y 1 A GLY 451  ? A GLY 106  
107 1 Y 1 A GLY 452  ? A GLY 107  
108 1 Y 1 A VAL 453  ? A VAL 108  
109 1 Y 1 A ASN 454  ? A ASN 109  
110 1 Y 1 A GLY 455  ? A GLY 110  
111 1 Y 1 A LYS 456  ? A LYS 111  
112 1 Y 1 A ASN 457  ? A ASN 112  
113 1 Y 1 A LEU 458  ? A LEU 113  
114 1 Y 1 A GLY 459  ? A GLY 114  
115 1 Y 1 A PRO 460  ? A PRO 115  
116 1 Y 1 A ILE 461  ? A ILE 116  
117 1 Y 1 A ASN 462  ? A ASN 117  
118 1 Y 1 A GLU 463  ? A GLU 118  
119 1 Y 1 A TRP 464  ? A TRP 119  
120 1 Y 1 A TRP 465  ? A TRP 120  
121 1 Y 1 A ILE 466  ? A ILE 121  
122 1 Y 1 A THR 467  ? A THR 122  
123 1 Y 1 A GLY 468  ? A GLY 123  
124 1 Y 1 A PHE 469  ? A PHE 124  
125 1 Y 1 A ASP 470  ? A ASP 125  
126 1 Y 1 A GLY 471  ? A GLY 126  
127 1 Y 1 A GLY 472  ? A GLY 127  
128 1 Y 1 A GLU 473  ? A GLU 128  
129 1 Y 1 A LYS 474  ? A LYS 129  
130 1 Y 1 A ALA 475  ? A ALA 130  
131 1 Y 1 A LEU 476  ? A LEU 131  
132 1 Y 1 A ILE 477  ? A ILE 132  
133 1 Y 1 A GLY 478  ? A GLY 133  
134 1 Y 1 A PHE 479  ? A PHE 134  
135 1 Y 1 A SER 480  ? A SER 135  
136 1 Y 1 A THR 481  ? A THR 136  
137 1 Y 1 A SER 482  ? A SER 137  
138 1 Y 1 A PHE 483  ? A PHE 138  
139 1 Y 1 A ALA 484  ? A ALA 139  
140 1 Y 1 A GLU 485  ? A GLU 140  
141 1 Y 1 A TYR 486  ? A TYR 141  
142 1 Y 1 A ILE 487  ? A ILE 142  
143 1 Y 1 A LEU 488  ? A LEU 143  
144 1 Y 1 A MET 489  ? A MET 144  
145 1 Y 1 A ASP 490  ? A ASP 145  
146 1 Y 1 A PRO 491  ? A PRO 146  
147 1 Y 1 A SER 492  ? A SER 147  
148 1 Y 1 A PRO 493  ? A PRO 148  
149 1 Y 1 A GLU 494  ? A GLU 149  
150 1 Y 1 A TYR 495  ? A TYR 150  
151 1 Y 1 A ALA 496  ? A ALA 151  
152 1 Y 1 A PRO 497  ? A PRO 152  
153 1 Y 1 A ILE 498  ? A ILE 153  
154 1 Y 1 A PHE 499  ? A PHE 154  
155 1 Y 1 A GLY 500  ? A GLY 155  
156 1 Y 1 A LEU 501  ? A LEU 156  
157 1 Y 1 A MET 502  ? A MET 157  
158 1 Y 1 A GLN 503  ? A GLN 158  
159 1 Y 1 A GLU 504  ? A GLU 159  
160 1 Y 1 A LYS 505  ? A LYS 160  
161 1 Y 1 A ILE 506  ? A ILE 161  
162 1 Y 1 A TYR 507  ? A TYR 162  
163 1 Y 1 A ILE 508  ? A ILE 163  
164 1 Y 1 A SER 509  ? A SER 164  
165 1 Y 1 A LYS 510  ? A LYS 165  
166 1 Y 1 A ILE 511  ? A ILE 166  
167 1 Y 1 A VAL 512  ? A VAL 167  
168 1 Y 1 A VAL 513  ? A VAL 168  
169 1 Y 1 A GLU 514  ? A GLU 169  
170 1 Y 1 A PHE 515  ? A PHE 170  
171 1 Y 1 A LEU 516  ? A LEU 171  
172 1 Y 1 A GLN 517  ? A GLN 172  
173 1 Y 1 A SER 518  ? A SER 173  
174 1 Y 1 A ASN 519  ? A ASN 174  
175 1 Y 1 A SER 520  ? A SER 175  
176 1 Y 1 A ASP 521  ? A ASP 176  
177 1 Y 1 A SER 522  ? A SER 177  
178 1 Y 1 A THR 523  ? A THR 178  
179 1 Y 1 A TYR 524  ? A TYR 179  
180 1 Y 1 A GLU 525  ? A GLU 180  
181 1 Y 1 A ASP 526  ? A ASP 181  
182 1 Y 1 A LEU 527  ? A LEU 182  
183 1 Y 1 A ILE 528  ? A ILE 183  
184 1 Y 1 A ASN 529  ? A ASN 184  
185 1 Y 1 A LYS 530  ? A LYS 185  
186 1 Y 1 A ILE 531  ? A ILE 186  
187 1 Y 1 A GLU 532  ? A GLU 187  
188 1 Y 1 A THR 533  ? A THR 188  
189 1 Y 1 A THR 534  ? A THR 189  
190 1 Y 1 A VAL 535  ? A VAL 190  
191 1 Y 1 A PRO 536  ? A PRO 191  
192 1 Y 1 A PRO 537  ? A PRO 192  
193 1 Y 1 A SER 538  ? A SER 193  
194 1 Y 1 A GLY 539  ? A GLY 194  
195 1 Y 1 A LEU 540  ? A LEU 195  
196 1 Y 1 A ASN 541  ? A ASN 196  
197 1 Y 1 A LEU 542  ? A LEU 197  
198 1 Y 1 A ASN 543  ? A ASN 198  
199 1 Y 1 A ARG 544  ? A ARG 199  
200 1 Y 1 A PHE 545  ? A PHE 200  
201 1 Y 1 A THR 546  ? A THR 201  
202 1 Y 1 A GLU 547  ? A GLU 202  
203 1 Y 1 A ASP 548  ? A ASP 203  
204 1 Y 1 A SER 549  ? A SER 204  
205 1 Y 1 A LEU 550  ? A LEU 205  
206 1 Y 1 A LEU 551  ? A LEU 206  
207 1 Y 1 A ARG 552  ? A ARG 207  
208 1 Y 1 A HIS 553  ? A HIS 208  
209 1 Y 1 A ALA 554  ? A ALA 209  
210 1 Y 1 A GLN 555  ? A GLN 210  
211 1 Y 1 A PHE 556  ? A PHE 211  
212 1 Y 1 A VAL 557  ? A VAL 212  
213 1 Y 1 A VAL 558  ? A VAL 213  
214 1 Y 1 A GLU 559  ? A GLU 214  
215 1 Y 1 A GLN 560  ? A GLN 215  
216 1 Y 1 A VAL 561  ? A VAL 216  
217 1 Y 1 A GLU 562  ? A GLU 217  
218 1 Y 1 A SER 563  ? A SER 218  
219 1 Y 1 A TYR 564  ? A TYR 219  
220 1 Y 1 A ASP 565  ? A ASP 220  
221 1 Y 1 A GLU 566  ? A GLU 221  
222 1 Y 1 A ALA 567  ? A ALA 222  
223 1 Y 1 A GLY 568  ? A GLY 223  
224 1 Y 1 A ASP 569  ? A ASP 224  
225 1 Y 1 A SER 570  ? A SER 225  
226 1 Y 1 A ASP 571  ? A ASP 226  
227 1 Y 1 A GLU 572  ? A GLU 227  
228 1 Y 1 A GLN 573  ? A GLN 228  
229 1 Y 1 A PRO 574  ? A PRO 229  
230 1 Y 1 A ILE 575  ? A ILE 230  
231 1 Y 1 A PHE 576  ? A PHE 231  
232 1 Y 1 A LEU 577  ? A LEU 232  
233 1 Y 1 A THR 578  ? A THR 233  
234 1 Y 1 A PRO 579  ? A PRO 234  
235 1 Y 1 A CYS 580  ? A CYS 235  
236 1 Y 1 A MET 581  ? A MET 236  
237 1 Y 1 A ARG 582  ? A ARG 237  
238 1 Y 1 A ASP 583  ? A ASP 238  
239 1 Y 1 A LEU 584  ? A LEU 239  
240 1 Y 1 A ILE 585  ? A ILE 240  
241 1 Y 1 A LYS 586  ? A LYS 241  
242 1 Y 1 A LEU 587  ? A LEU 242  
243 1 Y 1 A ALA 588  ? A ALA 243  
244 1 Y 1 A GLY 589  ? A GLY 244  
245 1 Y 1 A VAL 590  ? A VAL 245  
246 1 Y 1 A THR 591  ? A THR 246  
247 1 Y 1 A LEU 592  ? A LEU 247  
248 1 Y 1 A GLY 593  ? A GLY 248  
249 1 Y 1 A GLN 594  ? A GLN 249  
250 1 Y 1 A ARG 595  ? A ARG 250  
251 1 Y 1 A ARG 596  ? A ARG 251  
252 1 Y 1 A ALA 597  ? A ALA 252  
253 1 Y 1 A GLN 598  ? A GLN 253  
254 1 Y 1 A ALA 599  ? A ALA 254  
255 1 Y 1 A ARG 600  ? A ARG 255  
256 1 Y 1 A ARG 601  ? A ARG 256  
257 1 Y 1 A GLN 602  ? A GLN 257  
258 1 Y 1 A THR 603  ? A THR 258  
259 1 Y 1 A ILE 604  ? A ILE 259  
260 1 Y 1 A ARG 605  ? A ARG 260  
261 1 Y 1 A HIS 606  ? A HIS 261  
262 1 Y 1 A SER 607  ? A SER 262  
263 1 Y 1 A THR 608  ? A THR 263  
264 1 Y 1 A ARG 609  ? A ARG 264  
265 1 Y 1 A GLU 610  ? A GLU 265  
266 1 Y 1 A LYS 611  ? A LYS 266  
267 1 Y 1 A ASP 612  ? A ASP 267  
268 1 Y 1 A ARG 613  ? A ARG 268  
269 1 Y 1 A ASP 640  ? A ASP 295  
270 1 Y 1 A ARG 641  ? A ARG 296  
271 1 Y 1 A GLU 642  ? A GLU 297  
272 1 Y 1 A ASP 643  ? A ASP 298  
273 1 Y 1 A LYS 644  ? A LYS 299  
274 1 Y 1 A GLU 645  ? A GLU 300  
275 1 Y 1 A ASN 646  ? A ASN 301  
276 1 Y 1 A ALA 647  ? A ALA 302  
277 1 Y 1 A PHE 648  ? A PHE 303  
278 1 Y 1 A LYS 649  ? A LYS 304  
279 1 Y 1 A ARG 650  ? A ARG 305  
280 1 Y 1 A ARG 651  ? A ARG 306  
281 1 Y 1 A ARG 652  ? A ARG 307  
282 1 Y 1 A CYS 653  ? A CYS 308  
283 1 Y 1 A GLY 654  ? A GLY 309  
284 1 Y 1 A VAL 655  ? A VAL 310  
285 1 Y 1 A CYS 656  ? A CYS 311  
286 1 Y 1 A GLU 657  ? A GLU 312  
287 1 Y 1 A VAL 658  ? A VAL 313  
288 1 Y 1 A CYS 659  ? A CYS 314  
289 1 Y 1 A GLN 660  ? A GLN 315  
290 1 Y 1 A GLN 661  ? A GLN 316  
291 1 Y 1 A PRO 662  ? A PRO 317  
292 1 Y 1 A GLU 663  ? A GLU 318  
293 1 Y 1 A CYS 664  ? A CYS 319  
294 1 Y 1 A GLY 665  ? A GLY 320  
295 1 Y 1 A LYS 666  ? A LYS 321  
296 1 Y 1 A CYS 667  ? A CYS 322  
297 1 Y 1 A LYS 668  ? A LYS 323  
298 1 Y 1 A ALA 669  ? A ALA 324  
299 1 Y 1 A CYS 670  ? A CYS 325  
300 1 Y 1 A LYS 671  ? A LYS 326  
301 1 Y 1 A ASP 672  ? A ASP 327  
302 1 Y 1 A MET 673  ? A MET 328  
303 1 Y 1 A VAL 674  ? A VAL 329  
304 1 Y 1 A LYS 675  ? A LYS 330  
305 1 Y 1 A PHE 676  ? A PHE 331  
306 1 Y 1 A GLY 677  ? A GLY 332  
307 1 Y 1 A GLY 678  ? A GLY 333  
308 1 Y 1 A SER 679  ? A SER 334  
309 1 Y 1 A GLY 680  ? A GLY 335  
310 1 Y 1 A ARG 681  ? A ARG 336  
311 1 Y 1 A SER 682  ? A SER 337  
312 1 Y 1 A LYS 683  ? A LYS 338  
313 1 Y 1 A GLN 684  ? A GLN 339  
314 1 Y 1 A ALA 685  ? A ALA 340  
315 1 Y 1 A CYS 686  ? A CYS 341  
316 1 Y 1 A GLN 687  ? A GLN 342  
317 1 Y 1 A GLU 688  ? A GLU 343  
318 1 Y 1 A ARG 689  ? A ARG 344  
319 1 Y 1 A ARG 690  ? A ARG 345  
320 1 Y 1 A CYS 691  ? A CYS 346  
321 1 Y 1 A PRO 692  ? A PRO 347  
322 1 Y 1 A ASN 693  ? A ASN 348  
323 1 Y 1 A MET 694  ? A MET 349  
324 1 Y 1 A ALA 695  ? A ALA 350  
325 1 Y 1 A MET 696  ? A MET 351  
326 1 Y 1 A LYS 697  ? A LYS 352  
327 1 Y 1 A GLU 698  ? A GLU 353  
328 1 Y 1 A ALA 699  ? A ALA 354  
329 1 Y 1 A ASP 700  ? A ASP 355  
330 1 Y 1 A ASP 701  ? A ASP 356  
331 1 Y 1 A ASP 702  ? A ASP 357  
332 1 Y 1 A GLU 703  ? A GLU 358  
333 1 Y 1 A GLU 704  ? A GLU 359  
334 1 Y 1 A VAL 705  ? A VAL 360  
335 1 Y 1 A ASP 706  ? A ASP 361  
336 1 Y 1 A ASP 707  ? A ASP 362  
337 1 Y 1 A ASN 708  ? A ASN 363  
338 1 Y 1 A ILE 709  ? A ILE 364  
339 1 Y 1 A PRO 710  ? A PRO 365  
340 1 Y 1 A GLU 711  ? A GLU 366  
341 1 Y 1 A MET 712  ? A MET 367  
342 1 Y 1 A PRO 713  ? A PRO 368  
343 1 Y 1 A SER 714  ? A SER 369  
344 1 Y 1 A PRO 715  ? A PRO 370  
345 1 Y 1 A LYS 716  ? A LYS 371  
346 1 Y 1 A LYS 717  ? A LYS 372  
347 1 Y 1 A MET 718  ? A MET 373  
348 1 Y 1 A HIS 719  ? A HIS 374  
349 1 Y 1 A ASN 727  ? A ASN 382  
350 1 Y 1 A LYS 728  ? A LYS 383  
351 1 Y 1 A ASN 729  ? A ASN 384  
352 1 Y 1 A ARG 730  ? A ARG 385  
353 1 Y 1 A GLY 735  ? A GLY 390  
354 1 Y 1 A GLU 736  ? A GLU 391  
355 1 Y 1 A ALA 737  ? A ALA 392  
356 1 Y 1 A VAL 738  ? A VAL 393  
357 1 Y 1 A LYS 739  ? A LYS 394  
358 1 Y 1 A THR 740  ? A THR 395  
359 1 Y 1 A ASP 741  ? A ASP 396  
360 1 Y 1 A GLY 742  ? A GLY 397  
361 1 Y 1 A LYS 743  ? A LYS 398  
362 1 Y 1 A ASP 850  ? A ASP 505  
363 1 Y 1 A PRO 851  ? A PRO 506  
364 1 Y 1 A GLU 852  ? A GLU 507  
365 1 Y 1 A SER 853  ? A SER 508  
366 1 Y 1 A LEU 854  ? A LEU 509  
367 1 Y 1 A LEU 855  ? A LEU 510  
368 1 Y 1 A GLU 856  ? A GLU 511  
369 1 Y 1 A GLY 857  ? A GLY 512  
370 1 Y 1 A ASP 858  ? A ASP 513  
371 1 Y 1 A ASP 859  ? A ASP 514  
372 1 Y 1 A GLN 883  ? A GLN 538  
373 1 Y 1 A PRO 884  ? A PRO 539  
374 1 Y 1 A THR 885  ? A THR 540  
375 1 Y 1 A GLU 886  ? A GLU 541  
376 1 Y 1 A ASP 887  ? A ASP 542  
377 1 Y 1 A ASN 888  ? A ASN 543  
378 1 Y 1 A LYS 889  ? A LYS 544  
379 1 Y 1 A SER 954  ? A SER 609  
380 1 Y 1 A PRO 955  ? A PRO 610  
381 1 Y 1 A VAL 956  ? A VAL 611  
382 1 Y 1 A LYS 957  ? A LYS 612  
383 1 Y 1 A ARG 958  ? A ARG 613  
384 1 Y 1 A PRO 959  ? A PRO 614  
385 1 Y 1 A ARG 960  ? A ARG 615  
386 1 Y 1 A LYS 961  ? A LYS 616  
387 1 Y 1 A GLY 1107 ? A GLY 762  
388 1 Y 1 A ASN 1108 ? A ASN 763  
389 1 Y 1 A LYS 1109 ? A LYS 764  
390 1 Y 1 A GLY 1110 ? A GLY 765  
391 1 Y 1 A LYS 1111 ? A LYS 766  
392 1 Y 1 A GLY 1112 ? A GLY 767  
393 1 Y 1 A LYS 1113 ? A LYS 768  
394 1 Y 1 A GLY 1114 ? A GLY 769  
395 1 Y 1 A LYS 1115 ? A LYS 770  
396 1 Y 1 A GLY 1116 ? A GLY 771  
397 1 Y 1 A LYS 1117 ? A LYS 772  
398 1 Y 1 A GLY 1118 ? A GLY 773  
399 1 Y 1 A LYS 1119 ? A LYS 774  
400 1 Y 1 A PRO 1120 ? A PRO 775  
401 1 Y 1 A LYS 1121 ? A LYS 776  
402 1 Y 1 A SER 1122 ? A SER 777  
403 1 Y 1 A GLN 1123 ? A GLN 778  
404 1 Y 1 A ALA 1124 ? A ALA 779  
405 1 Y 1 A CYS 1125 ? A CYS 780  
406 1 Y 1 A GLU 1126 ? A GLU 781  
407 1 Y 1 A PRO 1127 ? A PRO 782  
408 1 Y 1 A SER 1128 ? A SER 783  
409 1 Y 1 A GLU 1129 ? A GLU 784  
410 1 Y 1 A PRO 1130 ? A PRO 785  
411 1 Y 1 A GLU 1131 ? A GLU 786  
412 1 Y 1 A ILE 1132 ? A ILE 787  
413 1 Y 1 A GLU 1133 ? A GLU 788  
414 1 Y 1 A ILE 1134 ? A ILE 789  
415 1 Y 1 A GLU 1480 ? A GLU 1135 
416 1 Y 1 A ALA 1481 ? A ALA 1136 
417 1 Y 1 A GLY 1482 ? A GLY 1137 
418 1 Y 1 A LYS 1483 ? A LYS 1138 
419 1 Y 1 A ALA 1606 ? A ALA 1261 
420 1 Y 1 A LYS 1607 ? A LYS 1262 
421 1 Y 1 A ILE 1608 ? A ILE 1263 
422 1 Y 1 A LYS 1609 ? A LYS 1264 
423 1 Y 1 A GLU 1610 ? A GLU 1265 
424 1 Y 1 A GLU 1611 ? A GLU 1266 
425 1 Y 1 A GLU 1612 ? A GLU 1267 
426 1 Y 1 A ALA 1613 ? A ALA 1268 
427 1 Y 1 A ALA 1614 ? A ALA 1269 
428 1 Y 1 A LYS 1615 ? A LYS 1270 
429 1 Y 1 A ASP 1616 ? A ASP 1271 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
5CM N1     N  N N 1   
5CM C2     C  N N 2   
5CM N3     N  N N 3   
5CM C4     C  N N 4   
5CM C5     C  N N 5   
5CM C5A    C  N N 6   
5CM C6     C  N N 7   
5CM O2     O  N N 8   
5CM N4     N  N N 9   
5CM "C1'"  C  N R 10  
5CM "C2'"  C  N N 11  
5CM "C3'"  C  N S 12  
5CM "C4'"  C  N R 13  
5CM "O4'"  O  N N 14  
5CM "O3'"  O  N N 15  
5CM "C5'"  C  N N 16  
5CM "O5'"  O  N N 17  
5CM P      P  N N 18  
5CM OP1    O  N N 19  
5CM OP2    O  N N 20  
5CM OP3    O  N N 21  
5CM H5A1   H  N N 22  
5CM H5A2   H  N N 23  
5CM H5A3   H  N N 24  
5CM H6     H  N N 25  
5CM HN41   H  N N 26  
5CM HN42   H  N N 27  
5CM "H1'"  H  N N 28  
5CM "H2'"  H  N N 29  
5CM "H2''" H  N N 30  
5CM "H3'"  H  N N 31  
5CM "H4'"  H  N N 32  
5CM "HO3'" H  N N 33  
5CM "H5'"  H  N N 34  
5CM "H5''" H  N N 35  
5CM HOP2   H  N N 36  
5CM HOP3   H  N N 37  
ALA N      N  N N 38  
ALA CA     C  N S 39  
ALA C      C  N N 40  
ALA O      O  N N 41  
ALA CB     C  N N 42  
ALA OXT    O  N N 43  
ALA H      H  N N 44  
ALA H2     H  N N 45  
ALA HA     H  N N 46  
ALA HB1    H  N N 47  
ALA HB2    H  N N 48  
ALA HB3    H  N N 49  
ALA HXT    H  N N 50  
ARG N      N  N N 51  
ARG CA     C  N S 52  
ARG C      C  N N 53  
ARG O      O  N N 54  
ARG CB     C  N N 55  
ARG CG     C  N N 56  
ARG CD     C  N N 57  
ARG NE     N  N N 58  
ARG CZ     C  N N 59  
ARG NH1    N  N N 60  
ARG NH2    N  N N 61  
ARG OXT    O  N N 62  
ARG H      H  N N 63  
ARG H2     H  N N 64  
ARG HA     H  N N 65  
ARG HB2    H  N N 66  
ARG HB3    H  N N 67  
ARG HG2    H  N N 68  
ARG HG3    H  N N 69  
ARG HD2    H  N N 70  
ARG HD3    H  N N 71  
ARG HE     H  N N 72  
ARG HH11   H  N N 73  
ARG HH12   H  N N 74  
ARG HH21   H  N N 75  
ARG HH22   H  N N 76  
ARG HXT    H  N N 77  
ASN N      N  N N 78  
ASN CA     C  N S 79  
ASN C      C  N N 80  
ASN O      O  N N 81  
ASN CB     C  N N 82  
ASN CG     C  N N 83  
ASN OD1    O  N N 84  
ASN ND2    N  N N 85  
ASN OXT    O  N N 86  
ASN H      H  N N 87  
ASN H2     H  N N 88  
ASN HA     H  N N 89  
ASN HB2    H  N N 90  
ASN HB3    H  N N 91  
ASN HD21   H  N N 92  
ASN HD22   H  N N 93  
ASN HXT    H  N N 94  
ASP N      N  N N 95  
ASP CA     C  N S 96  
ASP C      C  N N 97  
ASP O      O  N N 98  
ASP CB     C  N N 99  
ASP CG     C  N N 100 
ASP OD1    O  N N 101 
ASP OD2    O  N N 102 
ASP OXT    O  N N 103 
ASP H      H  N N 104 
ASP H2     H  N N 105 
ASP HA     H  N N 106 
ASP HB2    H  N N 107 
ASP HB3    H  N N 108 
ASP HD2    H  N N 109 
ASP HXT    H  N N 110 
CYS N      N  N N 111 
CYS CA     C  N R 112 
CYS C      C  N N 113 
CYS O      O  N N 114 
CYS CB     C  N N 115 
CYS SG     S  N N 116 
CYS OXT    O  N N 117 
CYS H      H  N N 118 
CYS H2     H  N N 119 
CYS HA     H  N N 120 
CYS HB2    H  N N 121 
CYS HB3    H  N N 122 
CYS HG     H  N N 123 
CYS HXT    H  N N 124 
DA  OP3    O  N N 125 
DA  P      P  N N 126 
DA  OP1    O  N N 127 
DA  OP2    O  N N 128 
DA  "O5'"  O  N N 129 
DA  "C5'"  C  N N 130 
DA  "C4'"  C  N R 131 
DA  "O4'"  O  N N 132 
DA  "C3'"  C  N S 133 
DA  "O3'"  O  N N 134 
DA  "C2'"  C  N N 135 
DA  "C1'"  C  N R 136 
DA  N9     N  Y N 137 
DA  C8     C  Y N 138 
DA  N7     N  Y N 139 
DA  C5     C  Y N 140 
DA  C6     C  Y N 141 
DA  N6     N  N N 142 
DA  N1     N  Y N 143 
DA  C2     C  Y N 144 
DA  N3     N  Y N 145 
DA  C4     C  Y N 146 
DA  HOP3   H  N N 147 
DA  HOP2   H  N N 148 
DA  "H5'"  H  N N 149 
DA  "H5''" H  N N 150 
DA  "H4'"  H  N N 151 
DA  "H3'"  H  N N 152 
DA  "HO3'" H  N N 153 
DA  "H2'"  H  N N 154 
DA  "H2''" H  N N 155 
DA  "H1'"  H  N N 156 
DA  H8     H  N N 157 
DA  H61    H  N N 158 
DA  H62    H  N N 159 
DA  H2     H  N N 160 
DC  OP3    O  N N 161 
DC  P      P  N N 162 
DC  OP1    O  N N 163 
DC  OP2    O  N N 164 
DC  "O5'"  O  N N 165 
DC  "C5'"  C  N N 166 
DC  "C4'"  C  N R 167 
DC  "O4'"  O  N N 168 
DC  "C3'"  C  N S 169 
DC  "O3'"  O  N N 170 
DC  "C2'"  C  N N 171 
DC  "C1'"  C  N R 172 
DC  N1     N  N N 173 
DC  C2     C  N N 174 
DC  O2     O  N N 175 
DC  N3     N  N N 176 
DC  C4     C  N N 177 
DC  N4     N  N N 178 
DC  C5     C  N N 179 
DC  C6     C  N N 180 
DC  HOP3   H  N N 181 
DC  HOP2   H  N N 182 
DC  "H5'"  H  N N 183 
DC  "H5''" H  N N 184 
DC  "H4'"  H  N N 185 
DC  "H3'"  H  N N 186 
DC  "HO3'" H  N N 187 
DC  "H2'"  H  N N 188 
DC  "H2''" H  N N 189 
DC  "H1'"  H  N N 190 
DC  H41    H  N N 191 
DC  H42    H  N N 192 
DC  H5     H  N N 193 
DC  H6     H  N N 194 
DG  OP3    O  N N 195 
DG  P      P  N N 196 
DG  OP1    O  N N 197 
DG  OP2    O  N N 198 
DG  "O5'"  O  N N 199 
DG  "C5'"  C  N N 200 
DG  "C4'"  C  N R 201 
DG  "O4'"  O  N N 202 
DG  "C3'"  C  N S 203 
DG  "O3'"  O  N N 204 
DG  "C2'"  C  N N 205 
DG  "C1'"  C  N R 206 
DG  N9     N  Y N 207 
DG  C8     C  Y N 208 
DG  N7     N  Y N 209 
DG  C5     C  Y N 210 
DG  C6     C  N N 211 
DG  O6     O  N N 212 
DG  N1     N  N N 213 
DG  C2     C  N N 214 
DG  N2     N  N N 215 
DG  N3     N  N N 216 
DG  C4     C  Y N 217 
DG  HOP3   H  N N 218 
DG  HOP2   H  N N 219 
DG  "H5'"  H  N N 220 
DG  "H5''" H  N N 221 
DG  "H4'"  H  N N 222 
DG  "H3'"  H  N N 223 
DG  "HO3'" H  N N 224 
DG  "H2'"  H  N N 225 
DG  "H2''" H  N N 226 
DG  "H1'"  H  N N 227 
DG  H8     H  N N 228 
DG  H1     H  N N 229 
DG  H21    H  N N 230 
DG  H22    H  N N 231 
DT  OP3    O  N N 232 
DT  P      P  N N 233 
DT  OP1    O  N N 234 
DT  OP2    O  N N 235 
DT  "O5'"  O  N N 236 
DT  "C5'"  C  N N 237 
DT  "C4'"  C  N R 238 
DT  "O4'"  O  N N 239 
DT  "C3'"  C  N S 240 
DT  "O3'"  O  N N 241 
DT  "C2'"  C  N N 242 
DT  "C1'"  C  N R 243 
DT  N1     N  N N 244 
DT  C2     C  N N 245 
DT  O2     O  N N 246 
DT  N3     N  N N 247 
DT  C4     C  N N 248 
DT  O4     O  N N 249 
DT  C5     C  N N 250 
DT  C7     C  N N 251 
DT  C6     C  N N 252 
DT  HOP3   H  N N 253 
DT  HOP2   H  N N 254 
DT  "H5'"  H  N N 255 
DT  "H5''" H  N N 256 
DT  "H4'"  H  N N 257 
DT  "H3'"  H  N N 258 
DT  "HO3'" H  N N 259 
DT  "H2'"  H  N N 260 
DT  "H2''" H  N N 261 
DT  "H1'"  H  N N 262 
DT  H3     H  N N 263 
DT  H71    H  N N 264 
DT  H72    H  N N 265 
DT  H73    H  N N 266 
DT  H6     H  N N 267 
EIX SG     S  N N 268 
EIX "C1'"  C  N S 269 
EIX C2     C  N N 270 
EIX "C2'"  C  N N 271 
EIX "C3'"  C  N S 272 
EIX C4     C  N N 273 
EIX "C4'"  C  N R 274 
EIX C5     C  N R 275 
EIX "C5'"  C  N N 276 
EIX C6     C  N R 277 
EIX CM5    C  N N 278 
EIX F      F  N N 279 
EIX N1     N  N N 280 
EIX N3     N  N N 281 
EIX N4     N  N N 282 
EIX O2     O  N N 283 
EIX "O3'"  O  N N 284 
EIX "O4'"  O  N N 285 
EIX "O5'"  O  N N 286 
EIX OP3    O  N N 287 
EIX OP2    O  N N 288 
EIX P      P  N N 289 
EIX H1     H  N N 290 
EIX H2     H  N N 291 
EIX H3     H  N N 292 
EIX H4     H  N N 293 
EIX H5     H  N N 294 
EIX H6     H  N N 295 
EIX H7     H  N N 296 
EIX H8     H  N N 297 
EIX H9     H  N N 298 
EIX H10    H  N N 299 
EIX H11    H  N N 300 
EIX H12    H  N N 301 
EIX H14    H  N N 302 
EIX HO3    H  N N 303 
EIX H16    H  N N 304 
EIX H17    H  N N 305 
EIX OP1    O  N N 306 
EIX H18    H  N N 307 
GLN N      N  N N 308 
GLN CA     C  N S 309 
GLN C      C  N N 310 
GLN O      O  N N 311 
GLN CB     C  N N 312 
GLN CG     C  N N 313 
GLN CD     C  N N 314 
GLN OE1    O  N N 315 
GLN NE2    N  N N 316 
GLN OXT    O  N N 317 
GLN H      H  N N 318 
GLN H2     H  N N 319 
GLN HA     H  N N 320 
GLN HB2    H  N N 321 
GLN HB3    H  N N 322 
GLN HG2    H  N N 323 
GLN HG3    H  N N 324 
GLN HE21   H  N N 325 
GLN HE22   H  N N 326 
GLN HXT    H  N N 327 
GLU N      N  N N 328 
GLU CA     C  N S 329 
GLU C      C  N N 330 
GLU O      O  N N 331 
GLU CB     C  N N 332 
GLU CG     C  N N 333 
GLU CD     C  N N 334 
GLU OE1    O  N N 335 
GLU OE2    O  N N 336 
GLU OXT    O  N N 337 
GLU H      H  N N 338 
GLU H2     H  N N 339 
GLU HA     H  N N 340 
GLU HB2    H  N N 341 
GLU HB3    H  N N 342 
GLU HG2    H  N N 343 
GLU HG3    H  N N 344 
GLU HE2    H  N N 345 
GLU HXT    H  N N 346 
GLY N      N  N N 347 
GLY CA     C  N N 348 
GLY C      C  N N 349 
GLY O      O  N N 350 
GLY OXT    O  N N 351 
GLY H      H  N N 352 
GLY H2     H  N N 353 
GLY HA2    H  N N 354 
GLY HA3    H  N N 355 
GLY HXT    H  N N 356 
HIS N      N  N N 357 
HIS CA     C  N S 358 
HIS C      C  N N 359 
HIS O      O  N N 360 
HIS CB     C  N N 361 
HIS CG     C  Y N 362 
HIS ND1    N  Y N 363 
HIS CD2    C  Y N 364 
HIS CE1    C  Y N 365 
HIS NE2    N  Y N 366 
HIS OXT    O  N N 367 
HIS H      H  N N 368 
HIS H2     H  N N 369 
HIS HA     H  N N 370 
HIS HB2    H  N N 371 
HIS HB3    H  N N 372 
HIS HD1    H  N N 373 
HIS HD2    H  N N 374 
HIS HE1    H  N N 375 
HIS HE2    H  N N 376 
HIS HXT    H  N N 377 
ILE N      N  N N 378 
ILE CA     C  N S 379 
ILE C      C  N N 380 
ILE O      O  N N 381 
ILE CB     C  N S 382 
ILE CG1    C  N N 383 
ILE CG2    C  N N 384 
ILE CD1    C  N N 385 
ILE OXT    O  N N 386 
ILE H      H  N N 387 
ILE H2     H  N N 388 
ILE HA     H  N N 389 
ILE HB     H  N N 390 
ILE HG12   H  N N 391 
ILE HG13   H  N N 392 
ILE HG21   H  N N 393 
ILE HG22   H  N N 394 
ILE HG23   H  N N 395 
ILE HD11   H  N N 396 
ILE HD12   H  N N 397 
ILE HD13   H  N N 398 
ILE HXT    H  N N 399 
LEU N      N  N N 400 
LEU CA     C  N S 401 
LEU C      C  N N 402 
LEU O      O  N N 403 
LEU CB     C  N N 404 
LEU CG     C  N N 405 
LEU CD1    C  N N 406 
LEU CD2    C  N N 407 
LEU OXT    O  N N 408 
LEU H      H  N N 409 
LEU H2     H  N N 410 
LEU HA     H  N N 411 
LEU HB2    H  N N 412 
LEU HB3    H  N N 413 
LEU HG     H  N N 414 
LEU HD11   H  N N 415 
LEU HD12   H  N N 416 
LEU HD13   H  N N 417 
LEU HD21   H  N N 418 
LEU HD22   H  N N 419 
LEU HD23   H  N N 420 
LEU HXT    H  N N 421 
LYS N      N  N N 422 
LYS CA     C  N S 423 
LYS C      C  N N 424 
LYS O      O  N N 425 
LYS CB     C  N N 426 
LYS CG     C  N N 427 
LYS CD     C  N N 428 
LYS CE     C  N N 429 
LYS NZ     N  N N 430 
LYS OXT    O  N N 431 
LYS H      H  N N 432 
LYS H2     H  N N 433 
LYS HA     H  N N 434 
LYS HB2    H  N N 435 
LYS HB3    H  N N 436 
LYS HG2    H  N N 437 
LYS HG3    H  N N 438 
LYS HD2    H  N N 439 
LYS HD3    H  N N 440 
LYS HE2    H  N N 441 
LYS HE3    H  N N 442 
LYS HZ1    H  N N 443 
LYS HZ2    H  N N 444 
LYS HZ3    H  N N 445 
LYS HXT    H  N N 446 
MET N      N  N N 447 
MET CA     C  N S 448 
MET C      C  N N 449 
MET O      O  N N 450 
MET CB     C  N N 451 
MET CG     C  N N 452 
MET SD     S  N N 453 
MET CE     C  N N 454 
MET OXT    O  N N 455 
MET H      H  N N 456 
MET H2     H  N N 457 
MET HA     H  N N 458 
MET HB2    H  N N 459 
MET HB3    H  N N 460 
MET HG2    H  N N 461 
MET HG3    H  N N 462 
MET HE1    H  N N 463 
MET HE2    H  N N 464 
MET HE3    H  N N 465 
MET HXT    H  N N 466 
PHE N      N  N N 467 
PHE CA     C  N S 468 
PHE C      C  N N 469 
PHE O      O  N N 470 
PHE CB     C  N N 471 
PHE CG     C  Y N 472 
PHE CD1    C  Y N 473 
PHE CD2    C  Y N 474 
PHE CE1    C  Y N 475 
PHE CE2    C  Y N 476 
PHE CZ     C  Y N 477 
PHE OXT    O  N N 478 
PHE H      H  N N 479 
PHE H2     H  N N 480 
PHE HA     H  N N 481 
PHE HB2    H  N N 482 
PHE HB3    H  N N 483 
PHE HD1    H  N N 484 
PHE HD2    H  N N 485 
PHE HE1    H  N N 486 
PHE HE2    H  N N 487 
PHE HZ     H  N N 488 
PHE HXT    H  N N 489 
PRO N      N  N N 490 
PRO CA     C  N S 491 
PRO C      C  N N 492 
PRO O      O  N N 493 
PRO CB     C  N N 494 
PRO CG     C  N N 495 
PRO CD     C  N N 496 
PRO OXT    O  N N 497 
PRO H      H  N N 498 
PRO HA     H  N N 499 
PRO HB2    H  N N 500 
PRO HB3    H  N N 501 
PRO HG2    H  N N 502 
PRO HG3    H  N N 503 
PRO HD2    H  N N 504 
PRO HD3    H  N N 505 
PRO HXT    H  N N 506 
SAH N      N  N N 507 
SAH CA     C  N S 508 
SAH CB     C  N N 509 
SAH CG     C  N N 510 
SAH SD     S  N N 511 
SAH C      C  N N 512 
SAH O      O  N N 513 
SAH OXT    O  N N 514 
SAH "C5'"  C  N N 515 
SAH "C4'"  C  N S 516 
SAH "O4'"  O  N N 517 
SAH "C3'"  C  N S 518 
SAH "O3'"  O  N N 519 
SAH "C2'"  C  N R 520 
SAH "O2'"  O  N N 521 
SAH "C1'"  C  N R 522 
SAH N9     N  Y N 523 
SAH C8     C  Y N 524 
SAH N7     N  Y N 525 
SAH C5     C  Y N 526 
SAH C6     C  Y N 527 
SAH N6     N  N N 528 
SAH N1     N  Y N 529 
SAH C2     C  Y N 530 
SAH N3     N  Y N 531 
SAH C4     C  Y N 532 
SAH HN1    H  N N 533 
SAH HN2    H  N N 534 
SAH HA     H  N N 535 
SAH HB1    H  N N 536 
SAH HB2    H  N N 537 
SAH HG1    H  N N 538 
SAH HG2    H  N N 539 
SAH HXT    H  N N 540 
SAH "H5'1" H  N N 541 
SAH "H5'2" H  N N 542 
SAH "H4'"  H  N N 543 
SAH "H3'"  H  N N 544 
SAH "HO3'" H  N N 545 
SAH "H2'"  H  N N 546 
SAH "HO2'" H  N N 547 
SAH "H1'"  H  N N 548 
SAH H8     H  N N 549 
SAH HN61   H  N N 550 
SAH HN62   H  N N 551 
SAH H2     H  N N 552 
SER N      N  N N 553 
SER CA     C  N S 554 
SER C      C  N N 555 
SER O      O  N N 556 
SER CB     C  N N 557 
SER OG     O  N N 558 
SER OXT    O  N N 559 
SER H      H  N N 560 
SER H2     H  N N 561 
SER HA     H  N N 562 
SER HB2    H  N N 563 
SER HB3    H  N N 564 
SER HG     H  N N 565 
SER HXT    H  N N 566 
THR N      N  N N 567 
THR CA     C  N S 568 
THR C      C  N N 569 
THR O      O  N N 570 
THR CB     C  N R 571 
THR OG1    O  N N 572 
THR CG2    C  N N 573 
THR OXT    O  N N 574 
THR H      H  N N 575 
THR H2     H  N N 576 
THR HA     H  N N 577 
THR HB     H  N N 578 
THR HG1    H  N N 579 
THR HG21   H  N N 580 
THR HG22   H  N N 581 
THR HG23   H  N N 582 
THR HXT    H  N N 583 
TRP N      N  N N 584 
TRP CA     C  N S 585 
TRP C      C  N N 586 
TRP O      O  N N 587 
TRP CB     C  N N 588 
TRP CG     C  Y N 589 
TRP CD1    C  Y N 590 
TRP CD2    C  Y N 591 
TRP NE1    N  Y N 592 
TRP CE2    C  Y N 593 
TRP CE3    C  Y N 594 
TRP CZ2    C  Y N 595 
TRP CZ3    C  Y N 596 
TRP CH2    C  Y N 597 
TRP OXT    O  N N 598 
TRP H      H  N N 599 
TRP H2     H  N N 600 
TRP HA     H  N N 601 
TRP HB2    H  N N 602 
TRP HB3    H  N N 603 
TRP HD1    H  N N 604 
TRP HE1    H  N N 605 
TRP HE3    H  N N 606 
TRP HZ2    H  N N 607 
TRP HZ3    H  N N 608 
TRP HH2    H  N N 609 
TRP HXT    H  N N 610 
TYR N      N  N N 611 
TYR CA     C  N S 612 
TYR C      C  N N 613 
TYR O      O  N N 614 
TYR CB     C  N N 615 
TYR CG     C  Y N 616 
TYR CD1    C  Y N 617 
TYR CD2    C  Y N 618 
TYR CE1    C  Y N 619 
TYR CE2    C  Y N 620 
TYR CZ     C  Y N 621 
TYR OH     O  N N 622 
TYR OXT    O  N N 623 
TYR H      H  N N 624 
TYR H2     H  N N 625 
TYR HA     H  N N 626 
TYR HB2    H  N N 627 
TYR HB3    H  N N 628 
TYR HD1    H  N N 629 
TYR HD2    H  N N 630 
TYR HE1    H  N N 631 
TYR HE2    H  N N 632 
TYR HH     H  N N 633 
TYR HXT    H  N N 634 
VAL N      N  N N 635 
VAL CA     C  N S 636 
VAL C      C  N N 637 
VAL O      O  N N 638 
VAL CB     C  N N 639 
VAL CG1    C  N N 640 
VAL CG2    C  N N 641 
VAL OXT    O  N N 642 
VAL H      H  N N 643 
VAL H2     H  N N 644 
VAL HA     H  N N 645 
VAL HB     H  N N 646 
VAL HG11   H  N N 647 
VAL HG12   H  N N 648 
VAL HG13   H  N N 649 
VAL HG21   H  N N 650 
VAL HG22   H  N N 651 
VAL HG23   H  N N 652 
VAL HXT    H  N N 653 
ZN  ZN     ZN N N 654 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
5CM N1    C2     sing N N 1   
5CM N1    C6     sing N N 2   
5CM N1    "C1'"  sing N N 3   
5CM C2    N3     sing N N 4   
5CM C2    O2     doub N N 5   
5CM N3    C4     doub N N 6   
5CM C4    C5     sing N N 7   
5CM C4    N4     sing N N 8   
5CM C5    C5A    sing N N 9   
5CM C5    C6     doub N N 10  
5CM C5A   H5A1   sing N N 11  
5CM C5A   H5A2   sing N N 12  
5CM C5A   H5A3   sing N N 13  
5CM C6    H6     sing N N 14  
5CM N4    HN41   sing N N 15  
5CM N4    HN42   sing N N 16  
5CM "C1'" "C2'"  sing N N 17  
5CM "C1'" "O4'"  sing N N 18  
5CM "C1'" "H1'"  sing N N 19  
5CM "C2'" "C3'"  sing N N 20  
5CM "C2'" "H2'"  sing N N 21  
5CM "C2'" "H2''" sing N N 22  
5CM "C3'" "C4'"  sing N N 23  
5CM "C3'" "O3'"  sing N N 24  
5CM "C3'" "H3'"  sing N N 25  
5CM "C4'" "O4'"  sing N N 26  
5CM "C4'" "C5'"  sing N N 27  
5CM "C4'" "H4'"  sing N N 28  
5CM "O3'" "HO3'" sing N N 29  
5CM "C5'" "O5'"  sing N N 30  
5CM "C5'" "H5'"  sing N N 31  
5CM "C5'" "H5''" sing N N 32  
5CM "O5'" P      sing N N 33  
5CM P     OP1    doub N N 34  
5CM P     OP2    sing N N 35  
5CM P     OP3    sing N N 36  
5CM OP2   HOP2   sing N N 37  
5CM OP3   HOP3   sing N N 38  
ALA N     CA     sing N N 39  
ALA N     H      sing N N 40  
ALA N     H2     sing N N 41  
ALA CA    C      sing N N 42  
ALA CA    CB     sing N N 43  
ALA CA    HA     sing N N 44  
ALA C     O      doub N N 45  
ALA C     OXT    sing N N 46  
ALA CB    HB1    sing N N 47  
ALA CB    HB2    sing N N 48  
ALA CB    HB3    sing N N 49  
ALA OXT   HXT    sing N N 50  
ARG N     CA     sing N N 51  
ARG N     H      sing N N 52  
ARG N     H2     sing N N 53  
ARG CA    C      sing N N 54  
ARG CA    CB     sing N N 55  
ARG CA    HA     sing N N 56  
ARG C     O      doub N N 57  
ARG C     OXT    sing N N 58  
ARG CB    CG     sing N N 59  
ARG CB    HB2    sing N N 60  
ARG CB    HB3    sing N N 61  
ARG CG    CD     sing N N 62  
ARG CG    HG2    sing N N 63  
ARG CG    HG3    sing N N 64  
ARG CD    NE     sing N N 65  
ARG CD    HD2    sing N N 66  
ARG CD    HD3    sing N N 67  
ARG NE    CZ     sing N N 68  
ARG NE    HE     sing N N 69  
ARG CZ    NH1    sing N N 70  
ARG CZ    NH2    doub N N 71  
ARG NH1   HH11   sing N N 72  
ARG NH1   HH12   sing N N 73  
ARG NH2   HH21   sing N N 74  
ARG NH2   HH22   sing N N 75  
ARG OXT   HXT    sing N N 76  
ASN N     CA     sing N N 77  
ASN N     H      sing N N 78  
ASN N     H2     sing N N 79  
ASN CA    C      sing N N 80  
ASN CA    CB     sing N N 81  
ASN CA    HA     sing N N 82  
ASN C     O      doub N N 83  
ASN C     OXT    sing N N 84  
ASN CB    CG     sing N N 85  
ASN CB    HB2    sing N N 86  
ASN CB    HB3    sing N N 87  
ASN CG    OD1    doub N N 88  
ASN CG    ND2    sing N N 89  
ASN ND2   HD21   sing N N 90  
ASN ND2   HD22   sing N N 91  
ASN OXT   HXT    sing N N 92  
ASP N     CA     sing N N 93  
ASP N     H      sing N N 94  
ASP N     H2     sing N N 95  
ASP CA    C      sing N N 96  
ASP CA    CB     sing N N 97  
ASP CA    HA     sing N N 98  
ASP C     O      doub N N 99  
ASP C     OXT    sing N N 100 
ASP CB    CG     sing N N 101 
ASP CB    HB2    sing N N 102 
ASP CB    HB3    sing N N 103 
ASP CG    OD1    doub N N 104 
ASP CG    OD2    sing N N 105 
ASP OD2   HD2    sing N N 106 
ASP OXT   HXT    sing N N 107 
CYS N     CA     sing N N 108 
CYS N     H      sing N N 109 
CYS N     H2     sing N N 110 
CYS CA    C      sing N N 111 
CYS CA    CB     sing N N 112 
CYS CA    HA     sing N N 113 
CYS C     O      doub N N 114 
CYS C     OXT    sing N N 115 
CYS CB    SG     sing N N 116 
CYS CB    HB2    sing N N 117 
CYS CB    HB3    sing N N 118 
CYS SG    HG     sing N N 119 
CYS OXT   HXT    sing N N 120 
DA  OP3   P      sing N N 121 
DA  OP3   HOP3   sing N N 122 
DA  P     OP1    doub N N 123 
DA  P     OP2    sing N N 124 
DA  P     "O5'"  sing N N 125 
DA  OP2   HOP2   sing N N 126 
DA  "O5'" "C5'"  sing N N 127 
DA  "C5'" "C4'"  sing N N 128 
DA  "C5'" "H5'"  sing N N 129 
DA  "C5'" "H5''" sing N N 130 
DA  "C4'" "O4'"  sing N N 131 
DA  "C4'" "C3'"  sing N N 132 
DA  "C4'" "H4'"  sing N N 133 
DA  "O4'" "C1'"  sing N N 134 
DA  "C3'" "O3'"  sing N N 135 
DA  "C3'" "C2'"  sing N N 136 
DA  "C3'" "H3'"  sing N N 137 
DA  "O3'" "HO3'" sing N N 138 
DA  "C2'" "C1'"  sing N N 139 
DA  "C2'" "H2'"  sing N N 140 
DA  "C2'" "H2''" sing N N 141 
DA  "C1'" N9     sing N N 142 
DA  "C1'" "H1'"  sing N N 143 
DA  N9    C8     sing Y N 144 
DA  N9    C4     sing Y N 145 
DA  C8    N7     doub Y N 146 
DA  C8    H8     sing N N 147 
DA  N7    C5     sing Y N 148 
DA  C5    C6     sing Y N 149 
DA  C5    C4     doub Y N 150 
DA  C6    N6     sing N N 151 
DA  C6    N1     doub Y N 152 
DA  N6    H61    sing N N 153 
DA  N6    H62    sing N N 154 
DA  N1    C2     sing Y N 155 
DA  C2    N3     doub Y N 156 
DA  C2    H2     sing N N 157 
DA  N3    C4     sing Y N 158 
DC  OP3   P      sing N N 159 
DC  OP3   HOP3   sing N N 160 
DC  P     OP1    doub N N 161 
DC  P     OP2    sing N N 162 
DC  P     "O5'"  sing N N 163 
DC  OP2   HOP2   sing N N 164 
DC  "O5'" "C5'"  sing N N 165 
DC  "C5'" "C4'"  sing N N 166 
DC  "C5'" "H5'"  sing N N 167 
DC  "C5'" "H5''" sing N N 168 
DC  "C4'" "O4'"  sing N N 169 
DC  "C4'" "C3'"  sing N N 170 
DC  "C4'" "H4'"  sing N N 171 
DC  "O4'" "C1'"  sing N N 172 
DC  "C3'" "O3'"  sing N N 173 
DC  "C3'" "C2'"  sing N N 174 
DC  "C3'" "H3'"  sing N N 175 
DC  "O3'" "HO3'" sing N N 176 
DC  "C2'" "C1'"  sing N N 177 
DC  "C2'" "H2'"  sing N N 178 
DC  "C2'" "H2''" sing N N 179 
DC  "C1'" N1     sing N N 180 
DC  "C1'" "H1'"  sing N N 181 
DC  N1    C2     sing N N 182 
DC  N1    C6     sing N N 183 
DC  C2    O2     doub N N 184 
DC  C2    N3     sing N N 185 
DC  N3    C4     doub N N 186 
DC  C4    N4     sing N N 187 
DC  C4    C5     sing N N 188 
DC  N4    H41    sing N N 189 
DC  N4    H42    sing N N 190 
DC  C5    C6     doub N N 191 
DC  C5    H5     sing N N 192 
DC  C6    H6     sing N N 193 
DG  OP3   P      sing N N 194 
DG  OP3   HOP3   sing N N 195 
DG  P     OP1    doub N N 196 
DG  P     OP2    sing N N 197 
DG  P     "O5'"  sing N N 198 
DG  OP2   HOP2   sing N N 199 
DG  "O5'" "C5'"  sing N N 200 
DG  "C5'" "C4'"  sing N N 201 
DG  "C5'" "H5'"  sing N N 202 
DG  "C5'" "H5''" sing N N 203 
DG  "C4'" "O4'"  sing N N 204 
DG  "C4'" "C3'"  sing N N 205 
DG  "C4'" "H4'"  sing N N 206 
DG  "O4'" "C1'"  sing N N 207 
DG  "C3'" "O3'"  sing N N 208 
DG  "C3'" "C2'"  sing N N 209 
DG  "C3'" "H3'"  sing N N 210 
DG  "O3'" "HO3'" sing N N 211 
DG  "C2'" "C1'"  sing N N 212 
DG  "C2'" "H2'"  sing N N 213 
DG  "C2'" "H2''" sing N N 214 
DG  "C1'" N9     sing N N 215 
DG  "C1'" "H1'"  sing N N 216 
DG  N9    C8     sing Y N 217 
DG  N9    C4     sing Y N 218 
DG  C8    N7     doub Y N 219 
DG  C8    H8     sing N N 220 
DG  N7    C5     sing Y N 221 
DG  C5    C6     sing N N 222 
DG  C5    C4     doub Y N 223 
DG  C6    O6     doub N N 224 
DG  C6    N1     sing N N 225 
DG  N1    C2     sing N N 226 
DG  N1    H1     sing N N 227 
DG  C2    N2     sing N N 228 
DG  C2    N3     doub N N 229 
DG  N2    H21    sing N N 230 
DG  N2    H22    sing N N 231 
DG  N3    C4     sing N N 232 
DT  OP3   P      sing N N 233 
DT  OP3   HOP3   sing N N 234 
DT  P     OP1    doub N N 235 
DT  P     OP2    sing N N 236 
DT  P     "O5'"  sing N N 237 
DT  OP2   HOP2   sing N N 238 
DT  "O5'" "C5'"  sing N N 239 
DT  "C5'" "C4'"  sing N N 240 
DT  "C5'" "H5'"  sing N N 241 
DT  "C5'" "H5''" sing N N 242 
DT  "C4'" "O4'"  sing N N 243 
DT  "C4'" "C3'"  sing N N 244 
DT  "C4'" "H4'"  sing N N 245 
DT  "O4'" "C1'"  sing N N 246 
DT  "C3'" "O3'"  sing N N 247 
DT  "C3'" "C2'"  sing N N 248 
DT  "C3'" "H3'"  sing N N 249 
DT  "O3'" "HO3'" sing N N 250 
DT  "C2'" "C1'"  sing N N 251 
DT  "C2'" "H2'"  sing N N 252 
DT  "C2'" "H2''" sing N N 253 
DT  "C1'" N1     sing N N 254 
DT  "C1'" "H1'"  sing N N 255 
DT  N1    C2     sing N N 256 
DT  N1    C6     sing N N 257 
DT  C2    O2     doub N N 258 
DT  C2    N3     sing N N 259 
DT  N3    C4     sing N N 260 
DT  N3    H3     sing N N 261 
DT  C4    O4     doub N N 262 
DT  C4    C5     sing N N 263 
DT  C5    C7     sing N N 264 
DT  C5    C6     doub N N 265 
DT  C7    H71    sing N N 266 
DT  C7    H72    sing N N 267 
DT  C7    H73    sing N N 268 
DT  C6    H6     sing N N 269 
EIX "O3'" "C3'"  sing N N 270 
EIX "C3'" "C4'"  sing N N 271 
EIX "C3'" "C2'"  sing N N 272 
EIX "C4'" "C5'"  sing N N 273 
EIX "C4'" "O4'"  sing N N 274 
EIX "C5'" "O5'"  sing N N 275 
EIX "C2'" "C1'"  sing N N 276 
EIX "O5'" P      sing N N 277 
EIX P     OP3    sing N N 278 
EIX P     OP2    sing N N 279 
EIX "O4'" "C1'"  sing N N 280 
EIX "C1'" N1     sing N N 281 
EIX N1    C6     sing N N 282 
EIX N1    C2     sing N N 283 
EIX C6    SG     sing N N 284 
EIX C6    C5     sing N N 285 
EIX O2    C2     doub N N 286 
EIX C2    N3     sing N N 287 
EIX CM5   C5     sing N N 288 
EIX C5    F      sing N N 289 
EIX C5    C4     sing N N 290 
EIX N3    C4     doub N N 291 
EIX C4    N4     sing N N 292 
EIX SG    H1     sing N N 293 
EIX "C1'" H2     sing N N 294 
EIX "C2'" H3     sing N N 295 
EIX "C2'" H4     sing N N 296 
EIX "C3'" H5     sing N N 297 
EIX "C4'" H6     sing N N 298 
EIX "C5'" H7     sing N N 299 
EIX "C5'" H8     sing N N 300 
EIX C6    H9     sing N N 301 
EIX CM5   H10    sing N N 302 
EIX CM5   H11    sing N N 303 
EIX CM5   H12    sing N N 304 
EIX N4    H14    sing N N 305 
EIX "O3'" HO3    sing N N 306 
EIX OP3   H16    sing N N 307 
EIX OP2   H17    sing N N 308 
EIX P     OP1    doub N N 309 
EIX N4    H18    sing N N 310 
GLN N     CA     sing N N 311 
GLN N     H      sing N N 312 
GLN N     H2     sing N N 313 
GLN CA    C      sing N N 314 
GLN CA    CB     sing N N 315 
GLN CA    HA     sing N N 316 
GLN C     O      doub N N 317 
GLN C     OXT    sing N N 318 
GLN CB    CG     sing N N 319 
GLN CB    HB2    sing N N 320 
GLN CB    HB3    sing N N 321 
GLN CG    CD     sing N N 322 
GLN CG    HG2    sing N N 323 
GLN CG    HG3    sing N N 324 
GLN CD    OE1    doub N N 325 
GLN CD    NE2    sing N N 326 
GLN NE2   HE21   sing N N 327 
GLN NE2   HE22   sing N N 328 
GLN OXT   HXT    sing N N 329 
GLU N     CA     sing N N 330 
GLU N     H      sing N N 331 
GLU N     H2     sing N N 332 
GLU CA    C      sing N N 333 
GLU CA    CB     sing N N 334 
GLU CA    HA     sing N N 335 
GLU C     O      doub N N 336 
GLU C     OXT    sing N N 337 
GLU CB    CG     sing N N 338 
GLU CB    HB2    sing N N 339 
GLU CB    HB3    sing N N 340 
GLU CG    CD     sing N N 341 
GLU CG    HG2    sing N N 342 
GLU CG    HG3    sing N N 343 
GLU CD    OE1    doub N N 344 
GLU CD    OE2    sing N N 345 
GLU OE2   HE2    sing N N 346 
GLU OXT   HXT    sing N N 347 
GLY N     CA     sing N N 348 
GLY N     H      sing N N 349 
GLY N     H2     sing N N 350 
GLY CA    C      sing N N 351 
GLY CA    HA2    sing N N 352 
GLY CA    HA3    sing N N 353 
GLY C     O      doub N N 354 
GLY C     OXT    sing N N 355 
GLY OXT   HXT    sing N N 356 
HIS N     CA     sing N N 357 
HIS N     H      sing N N 358 
HIS N     H2     sing N N 359 
HIS CA    C      sing N N 360 
HIS CA    CB     sing N N 361 
HIS CA    HA     sing N N 362 
HIS C     O      doub N N 363 
HIS C     OXT    sing N N 364 
HIS CB    CG     sing N N 365 
HIS CB    HB2    sing N N 366 
HIS CB    HB3    sing N N 367 
HIS CG    ND1    sing Y N 368 
HIS CG    CD2    doub Y N 369 
HIS ND1   CE1    doub Y N 370 
HIS ND1   HD1    sing N N 371 
HIS CD2   NE2    sing Y N 372 
HIS CD2   HD2    sing N N 373 
HIS CE1   NE2    sing Y N 374 
HIS CE1   HE1    sing N N 375 
HIS NE2   HE2    sing N N 376 
HIS OXT   HXT    sing N N 377 
ILE N     CA     sing N N 378 
ILE N     H      sing N N 379 
ILE N     H2     sing N N 380 
ILE CA    C      sing N N 381 
ILE CA    CB     sing N N 382 
ILE CA    HA     sing N N 383 
ILE C     O      doub N N 384 
ILE C     OXT    sing N N 385 
ILE CB    CG1    sing N N 386 
ILE CB    CG2    sing N N 387 
ILE CB    HB     sing N N 388 
ILE CG1   CD1    sing N N 389 
ILE CG1   HG12   sing N N 390 
ILE CG1   HG13   sing N N 391 
ILE CG2   HG21   sing N N 392 
ILE CG2   HG22   sing N N 393 
ILE CG2   HG23   sing N N 394 
ILE CD1   HD11   sing N N 395 
ILE CD1   HD12   sing N N 396 
ILE CD1   HD13   sing N N 397 
ILE OXT   HXT    sing N N 398 
LEU N     CA     sing N N 399 
LEU N     H      sing N N 400 
LEU N     H2     sing N N 401 
LEU CA    C      sing N N 402 
LEU CA    CB     sing N N 403 
LEU CA    HA     sing N N 404 
LEU C     O      doub N N 405 
LEU C     OXT    sing N N 406 
LEU CB    CG     sing N N 407 
LEU CB    HB2    sing N N 408 
LEU CB    HB3    sing N N 409 
LEU CG    CD1    sing N N 410 
LEU CG    CD2    sing N N 411 
LEU CG    HG     sing N N 412 
LEU CD1   HD11   sing N N 413 
LEU CD1   HD12   sing N N 414 
LEU CD1   HD13   sing N N 415 
LEU CD2   HD21   sing N N 416 
LEU CD2   HD22   sing N N 417 
LEU CD2   HD23   sing N N 418 
LEU OXT   HXT    sing N N 419 
LYS N     CA     sing N N 420 
LYS N     H      sing N N 421 
LYS N     H2     sing N N 422 
LYS CA    C      sing N N 423 
LYS CA    CB     sing N N 424 
LYS CA    HA     sing N N 425 
LYS C     O      doub N N 426 
LYS C     OXT    sing N N 427 
LYS CB    CG     sing N N 428 
LYS CB    HB2    sing N N 429 
LYS CB    HB3    sing N N 430 
LYS CG    CD     sing N N 431 
LYS CG    HG2    sing N N 432 
LYS CG    HG3    sing N N 433 
LYS CD    CE     sing N N 434 
LYS CD    HD2    sing N N 435 
LYS CD    HD3    sing N N 436 
LYS CE    NZ     sing N N 437 
LYS CE    HE2    sing N N 438 
LYS CE    HE3    sing N N 439 
LYS NZ    HZ1    sing N N 440 
LYS NZ    HZ2    sing N N 441 
LYS NZ    HZ3    sing N N 442 
LYS OXT   HXT    sing N N 443 
MET N     CA     sing N N 444 
MET N     H      sing N N 445 
MET N     H2     sing N N 446 
MET CA    C      sing N N 447 
MET CA    CB     sing N N 448 
MET CA    HA     sing N N 449 
MET C     O      doub N N 450 
MET C     OXT    sing N N 451 
MET CB    CG     sing N N 452 
MET CB    HB2    sing N N 453 
MET CB    HB3    sing N N 454 
MET CG    SD     sing N N 455 
MET CG    HG2    sing N N 456 
MET CG    HG3    sing N N 457 
MET SD    CE     sing N N 458 
MET CE    HE1    sing N N 459 
MET CE    HE2    sing N N 460 
MET CE    HE3    sing N N 461 
MET OXT   HXT    sing N N 462 
PHE N     CA     sing N N 463 
PHE N     H      sing N N 464 
PHE N     H2     sing N N 465 
PHE CA    C      sing N N 466 
PHE CA    CB     sing N N 467 
PHE CA    HA     sing N N 468 
PHE C     O      doub N N 469 
PHE C     OXT    sing N N 470 
PHE CB    CG     sing N N 471 
PHE CB    HB2    sing N N 472 
PHE CB    HB3    sing N N 473 
PHE CG    CD1    doub Y N 474 
PHE CG    CD2    sing Y N 475 
PHE CD1   CE1    sing Y N 476 
PHE CD1   HD1    sing N N 477 
PHE CD2   CE2    doub Y N 478 
PHE CD2   HD2    sing N N 479 
PHE CE1   CZ     doub Y N 480 
PHE CE1   HE1    sing N N 481 
PHE CE2   CZ     sing Y N 482 
PHE CE2   HE2    sing N N 483 
PHE CZ    HZ     sing N N 484 
PHE OXT   HXT    sing N N 485 
PRO N     CA     sing N N 486 
PRO N     CD     sing N N 487 
PRO N     H      sing N N 488 
PRO CA    C      sing N N 489 
PRO CA    CB     sing N N 490 
PRO CA    HA     sing N N 491 
PRO C     O      doub N N 492 
PRO C     OXT    sing N N 493 
PRO CB    CG     sing N N 494 
PRO CB    HB2    sing N N 495 
PRO CB    HB3    sing N N 496 
PRO CG    CD     sing N N 497 
PRO CG    HG2    sing N N 498 
PRO CG    HG3    sing N N 499 
PRO CD    HD2    sing N N 500 
PRO CD    HD3    sing N N 501 
PRO OXT   HXT    sing N N 502 
SAH N     CA     sing N N 503 
SAH N     HN1    sing N N 504 
SAH N     HN2    sing N N 505 
SAH CA    CB     sing N N 506 
SAH CA    C      sing N N 507 
SAH CA    HA     sing N N 508 
SAH CB    CG     sing N N 509 
SAH CB    HB1    sing N N 510 
SAH CB    HB2    sing N N 511 
SAH CG    SD     sing N N 512 
SAH CG    HG1    sing N N 513 
SAH CG    HG2    sing N N 514 
SAH SD    "C5'"  sing N N 515 
SAH C     O      doub N N 516 
SAH C     OXT    sing N N 517 
SAH OXT   HXT    sing N N 518 
SAH "C5'" "C4'"  sing N N 519 
SAH "C5'" "H5'1" sing N N 520 
SAH "C5'" "H5'2" sing N N 521 
SAH "C4'" "O4'"  sing N N 522 
SAH "C4'" "C3'"  sing N N 523 
SAH "C4'" "H4'"  sing N N 524 
SAH "O4'" "C1'"  sing N N 525 
SAH "C3'" "O3'"  sing N N 526 
SAH "C3'" "C2'"  sing N N 527 
SAH "C3'" "H3'"  sing N N 528 
SAH "O3'" "HO3'" sing N N 529 
SAH "C2'" "O2'"  sing N N 530 
SAH "C2'" "C1'"  sing N N 531 
SAH "C2'" "H2'"  sing N N 532 
SAH "O2'" "HO2'" sing N N 533 
SAH "C1'" N9     sing N N 534 
SAH "C1'" "H1'"  sing N N 535 
SAH N9    C8     sing Y N 536 
SAH N9    C4     sing Y N 537 
SAH C8    N7     doub Y N 538 
SAH C8    H8     sing N N 539 
SAH N7    C5     sing Y N 540 
SAH C5    C6     sing Y N 541 
SAH C5    C4     doub Y N 542 
SAH C6    N6     sing N N 543 
SAH C6    N1     doub Y N 544 
SAH N6    HN61   sing N N 545 
SAH N6    HN62   sing N N 546 
SAH N1    C2     sing Y N 547 
SAH C2    N3     doub Y N 548 
SAH C2    H2     sing N N 549 
SAH N3    C4     sing Y N 550 
SER N     CA     sing N N 551 
SER N     H      sing N N 552 
SER N     H2     sing N N 553 
SER CA    C      sing N N 554 
SER CA    CB     sing N N 555 
SER CA    HA     sing N N 556 
SER C     O      doub N N 557 
SER C     OXT    sing N N 558 
SER CB    OG     sing N N 559 
SER CB    HB2    sing N N 560 
SER CB    HB3    sing N N 561 
SER OG    HG     sing N N 562 
SER OXT   HXT    sing N N 563 
THR N     CA     sing N N 564 
THR N     H      sing N N 565 
THR N     H2     sing N N 566 
THR CA    C      sing N N 567 
THR CA    CB     sing N N 568 
THR CA    HA     sing N N 569 
THR C     O      doub N N 570 
THR C     OXT    sing N N 571 
THR CB    OG1    sing N N 572 
THR CB    CG2    sing N N 573 
THR CB    HB     sing N N 574 
THR OG1   HG1    sing N N 575 
THR CG2   HG21   sing N N 576 
THR CG2   HG22   sing N N 577 
THR CG2   HG23   sing N N 578 
THR OXT   HXT    sing N N 579 
TRP N     CA     sing N N 580 
TRP N     H      sing N N 581 
TRP N     H2     sing N N 582 
TRP CA    C      sing N N 583 
TRP CA    CB     sing N N 584 
TRP CA    HA     sing N N 585 
TRP C     O      doub N N 586 
TRP C     OXT    sing N N 587 
TRP CB    CG     sing N N 588 
TRP CB    HB2    sing N N 589 
TRP CB    HB3    sing N N 590 
TRP CG    CD1    doub Y N 591 
TRP CG    CD2    sing Y N 592 
TRP CD1   NE1    sing Y N 593 
TRP CD1   HD1    sing N N 594 
TRP CD2   CE2    doub Y N 595 
TRP CD2   CE3    sing Y N 596 
TRP NE1   CE2    sing Y N 597 
TRP NE1   HE1    sing N N 598 
TRP CE2   CZ2    sing Y N 599 
TRP CE3   CZ3    doub Y N 600 
TRP CE3   HE3    sing N N 601 
TRP CZ2   CH2    doub Y N 602 
TRP CZ2   HZ2    sing N N 603 
TRP CZ3   CH2    sing Y N 604 
TRP CZ3   HZ3    sing N N 605 
TRP CH2   HH2    sing N N 606 
TRP OXT   HXT    sing N N 607 
TYR N     CA     sing N N 608 
TYR N     H      sing N N 609 
TYR N     H2     sing N N 610 
TYR CA    C      sing N N 611 
TYR CA    CB     sing N N 612 
TYR CA    HA     sing N N 613 
TYR C     O      doub N N 614 
TYR C     OXT    sing N N 615 
TYR CB    CG     sing N N 616 
TYR CB    HB2    sing N N 617 
TYR CB    HB3    sing N N 618 
TYR CG    CD1    doub Y N 619 
TYR CG    CD2    sing Y N 620 
TYR CD1   CE1    sing Y N 621 
TYR CD1   HD1    sing N N 622 
TYR CD2   CE2    doub Y N 623 
TYR CD2   HD2    sing N N 624 
TYR CE1   CZ     doub Y N 625 
TYR CE1   HE1    sing N N 626 
TYR CE2   CZ     sing Y N 627 
TYR CE2   HE2    sing N N 628 
TYR CZ    OH     sing N N 629 
TYR OH    HH     sing N N 630 
TYR OXT   HXT    sing N N 631 
VAL N     CA     sing N N 632 
VAL N     H      sing N N 633 
VAL N     H2     sing N N 634 
VAL CA    C      sing N N 635 
VAL CA    CB     sing N N 636 
VAL CA    HA     sing N N 637 
VAL C     O      doub N N 638 
VAL C     OXT    sing N N 639 
VAL CB    CG1    sing N N 640 
VAL CB    CG2    sing N N 641 
VAL CB    HB     sing N N 642 
VAL CG1   HG11   sing N N 643 
VAL CG1   HG12   sing N N 644 
VAL CG1   HG13   sing N N 645 
VAL CG2   HG21   sing N N 646 
VAL CG2   HG22   sing N N 647 
VAL CG2   HG23   sing N N 648 
VAL OXT   HXT    sing N N 649 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-01-05 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8XQC 
_em_admin.last_update        2025-01-15 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              
'Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 2 2 9606  'Homo sapiens'        ? ? ? ? ? 
? ? 3 3 32630 'synthetic construct' ? ? ? ? ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   2 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_entity_assembly_synthetic.cell                 ? 
_em_entity_assembly_synthetic.cellular_location    ? 
_em_entity_assembly_synthetic.entity_assembly_id   3 
_em_entity_assembly_synthetic.id                   1 
_em_entity_assembly_synthetic.ncbi_tax_id          32630 
_em_entity_assembly_synthetic.organ                ? 
_em_entity_assembly_synthetic.organelle            ? 
_em_entity_assembly_synthetic.organism             'synthetic construct' 
_em_entity_assembly_synthetic.strain               ? 
_em_entity_assembly_synthetic.tissue               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60.848 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8XQC 'double helix'        
8XQC 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B DC  2  1_555 C DG 11 1_555 0.103  -0.244 0.746  1.640   -9.200  -2.518 1 B_DC2:DG11_C B 2  ? C 11 ? 19 1 
1 B DT  3  1_555 C DA 10 1_555 -0.217 -0.138 0.363  -1.468  -13.250 -3.994 2 B_DT3:DA10_C B 3  ? C 10 ? 20 1 
1 B DT  4  1_555 C DA 9  1_555 -0.004 0.500  0.136  -10.511 -13.819 2.539  3 B_DT4:DA9_C  B 4  ? C 9  ? 20 1 
1 B DA  5  1_555 C DT 8  1_555 0.182  -0.148 -1.024 -11.627 -1.201  -2.230 4 B_DA5:DT8_C  B 5  ? C 8  ? 20 1 
1 B 5CM 6  1_555 C DG 7  1_555 1.131  0.008  -0.421 -1.283  6.371   10.258 5 B_5CM6:DG7_C B 6  ? C 7  ? 19 1 
1 B DA  9  1_555 C DT 4  1_555 -0.149 0.838  0.407  -7.311  -9.490  12.436 6 B_DA9:DT4_C  B 9  ? C 4  ? ?  ? 
1 B DA  10 1_555 C DT 3  1_555 0.103  -0.188 -0.753 -8.686  -2.450  3.139  7 B_DA10:DT3_C B 10 ? C 3  ? 20 1 
1 B DG  11 1_555 C DC 2  1_555 -0.168 -0.241 -0.890 -2.096  1.516   1.760  8 B_DG11:DC2_C B 11 ? C 2  ? 19 1 
1 B DG  12 1_555 C DC 1  1_555 -0.166 -0.193 -0.705 0.445   1.697   1.321  9 B_DG12:DC1_C B 12 ? C 1  ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B DC 2  1_555 C DG 11 1_555 B DT  3  1_555 C DA 10 1_555 -0.608 -0.876 3.218 1.780  -0.901 31.890 -1.431 1.422  3.203 -1.638 
-3.236 31.951 1 BB_DC2DT3:DA10DG11_CC B 2  ? C 11 ? B 3  ? C 10 ? 
1 B DT 3  1_555 C DA 10 1_555 B DT  4  1_555 C DA 9  1_555 0.197  -0.429 3.601 0.472  -1.083 33.275 -0.550 -0.257 3.615 -1.890 
-0.824 33.296 2 BB_DT3DT4:DA9DA10_CC  B 3  ? C 10 ? B 4  ? C 9  ? 
1 B DT 4  1_555 C DA 9  1_555 B DA  5  1_555 C DT 8  1_555 -0.605 1.022  3.471 1.405  4.884  41.105 0.884  1.017  3.543 6.925  
-1.992 41.404 3 BB_DT4DA5:DT8DA9_CC   B 4  ? C 9  ? B 5  ? C 8  ? 
1 B DA 5  1_555 C DT 8  1_555 B 5CM 6  1_555 C DG 7  1_555 1.271  0.045  3.553 -3.643 3.032  32.074 -0.489 -2.961 3.382 5.450  
6.549  32.414 4 BB_DA55CM6:DG7DT8_CC  B 5  ? C 8  ? B 6  ? C 7  ? 
1 B DA 9  1_555 C DT 4  1_555 B DA  10 1_555 C DT 3  1_555 -0.872 -0.042 3.684 0.062  2.742  35.288 -0.523 1.445  3.669 4.515  
-0.103 35.391 5 BB_DA9DA10:DT3DT4_CC  B 9  ? C 4  ? B 10 ? C 3  ? 
1 B DA 10 1_555 C DT 3  1_555 B DG  11 1_555 C DC 2  1_555 -0.085 -0.018 3.309 -2.241 4.821  31.008 -0.946 -0.267 3.267 8.936  
4.154  31.449 6 BB_DA10DG11:DC2DT3_CC B 10 ? C 3  ? B 11 ? C 2  ? 
1 B DG 11 1_555 C DC 2  1_555 B DG  12 1_555 C DC 1  1_555 0.183  -0.121 3.334 -0.943 1.742  37.377 -0.422 -0.411 3.320 2.716  
1.470  37.427 7 BB_DG11DG12:DC1DC2_CC B 11 ? C 2  ? B 12 ? C 1  ? 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           '18H02392, 19H05294, 19H05741,19J22030' 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8XQC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
F  
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . GLY A 1 269  ? 159.007 121.903 132.116 1.00 103.41 ? 614  GLY A N     1 
ATOM   2    C  CA    . GLY A 1 269  ? 158.717 121.277 133.393 1.00 106.19 ? 614  GLY A CA    1 
ATOM   3    C  C     . GLY A 1 269  ? 159.400 121.918 134.588 1.00 107.87 ? 614  GLY A C     1 
ATOM   4    O  O     . GLY A 1 269  ? 160.575 121.658 134.852 1.00 105.00 ? 614  GLY A O     1 
ATOM   5    N  N     . PRO A 1 270  ? 158.672 122.764 135.316 1.00 111.30 ? 615  PRO A N     1 
ATOM   6    C  CA    . PRO A 1 270  ? 159.254 123.389 136.510 1.00 109.34 ? 615  PRO A CA    1 
ATOM   7    C  C     . PRO A 1 270  ? 159.593 122.360 137.579 1.00 107.73 ? 615  PRO A C     1 
ATOM   8    O  O     . PRO A 1 270  ? 158.880 121.373 137.775 1.00 107.85 ? 615  PRO A O     1 
ATOM   9    C  CB    . PRO A 1 270  ? 158.154 124.347 136.985 1.00 106.98 ? 615  PRO A CB    1 
ATOM   10   C  CG    . PRO A 1 270  ? 157.264 124.541 135.802 1.00 103.02 ? 615  PRO A CG    1 
ATOM   11   C  CD    . PRO A 1 270  ? 157.311 123.253 135.042 1.00 106.43 ? 615  PRO A CD    1 
ATOM   12   N  N     . THR A 1 271  ? 160.696 122.611 138.281 1.00 99.07  ? 616  THR A N     1 
ATOM   13   C  CA    . THR A 1 271  ? 161.111 121.736 139.366 1.00 100.69 ? 616  THR A CA    1 
ATOM   14   C  C     . THR A 1 271  ? 160.245 121.960 140.601 1.00 101.29 ? 616  THR A C     1 
ATOM   15   O  O     . THR A 1 271  ? 159.902 123.091 140.951 1.00 100.89 ? 616  THR A O     1 
ATOM   16   C  CB    . THR A 1 271  ? 162.581 121.968 139.717 1.00 100.42 ? 616  THR A CB    1 
ATOM   17   O  OG1   . THR A 1 271  ? 162.680 122.998 140.708 1.00 101.36 ? 616  THR A OG1   1 
ATOM   18   C  CG2   . THR A 1 271  ? 163.361 122.385 138.479 1.00 98.54  ? 616  THR A CG2   1 
ATOM   19   N  N     . LYS A 1 272  ? 159.910 120.862 141.270 1.00 101.70 ? 617  LYS A N     1 
ATOM   20   C  CA    . LYS A 1 272  ? 159.032 120.920 142.427 1.00 99.18  ? 617  LYS A CA    1 
ATOM   21   C  C     . LYS A 1 272  ? 159.706 121.649 143.587 1.00 99.37  ? 617  LYS A C     1 
ATOM   22   O  O     . LYS A 1 272  ? 160.930 121.643 143.739 1.00 100.27 ? 617  LYS A O     1 
ATOM   23   C  CB    . LYS A 1 272  ? 158.623 119.512 142.854 1.00 98.17  ? 617  LYS A CB    1 
ATOM   24   C  CG    . LYS A 1 272  ? 157.544 118.900 141.981 1.00 96.96  ? 617  LYS A CG    1 
ATOM   25   C  CD    . LYS A 1 272  ? 157.676 117.388 141.913 1.00 99.74  ? 617  LYS A CD    1 
ATOM   26   C  CE    . LYS A 1 272  ? 156.314 116.716 141.829 1.00 99.71  ? 617  LYS A CE    1 
ATOM   27   N  NZ    . LYS A 1 272  ? 156.425 115.230 141.790 1.00 101.16 ? 617  LYS A NZ    1 
ATOM   28   N  N     . ALA A 1 273  ? 158.878 122.285 144.412 1.00 89.23  ? 618  ALA A N     1 
ATOM   29   C  CA    . ALA A 1 273  ? 159.381 123.062 145.535 1.00 88.59  ? 618  ALA A CA    1 
ATOM   30   C  C     . ALA A 1 273  ? 159.881 122.142 146.642 1.00 91.91  ? 618  ALA A C     1 
ATOM   31   O  O     . ALA A 1 273  ? 159.185 121.207 147.046 1.00 92.84  ? 618  ALA A O     1 
ATOM   32   C  CB    . ALA A 1 273  ? 158.283 123.978 146.070 1.00 85.58  ? 618  ALA A CB    1 
ATOM   33   N  N     . THR A 1 274  ? 161.086 122.411 147.138 1.00 80.58  ? 619  THR A N     1 
ATOM   34   C  CA    . THR A 1 274  ? 161.627 121.680 148.276 1.00 79.05  ? 619  THR A CA    1 
ATOM   35   C  C     . THR A 1 274  ? 161.304 122.458 149.545 1.00 82.73  ? 619  THR A C     1 
ATOM   36   O  O     . THR A 1 274  ? 161.467 123.682 149.592 1.00 82.70  ? 619  THR A O     1 
ATOM   37   C  CB    . THR A 1 274  ? 163.133 121.452 148.138 1.00 81.63  ? 619  THR A CB    1 
ATOM   38   O  OG1   . THR A 1 274  ? 163.597 120.658 149.236 1.00 88.14  ? 619  THR A OG1   1 
ATOM   39   C  CG2   . THR A 1 274  ? 163.887 122.762 148.136 1.00 82.47  ? 619  THR A CG2   1 
ATOM   40   N  N     . THR A 1 275  ? 160.802 121.757 150.555 1.00 76.37  ? 620  THR A N     1 
ATOM   41   C  CA    . THR A 1 275  ? 160.341 122.392 151.777 1.00 77.02  ? 620  THR A CA    1 
ATOM   42   C  C     . THR A 1 275  ? 160.817 121.611 152.988 1.00 74.58  ? 620  THR A C     1 
ATOM   43   O  O     . THR A 1 275  ? 161.060 120.404 152.918 1.00 69.37  ? 620  THR A O     1 
ATOM   44   C  CB    . THR A 1 275  ? 158.810 122.500 151.825 1.00 76.11  ? 620  THR A CB    1 
ATOM   45   O  OG1   . THR A 1 275  ? 158.246 121.203 152.053 1.00 75.38  ? 620  THR A OG1   1 
ATOM   46   C  CG2   . THR A 1 275  ? 158.266 123.062 150.532 1.00 72.94  ? 620  THR A CG2   1 
ATOM   47   N  N     . THR A 1 276  ? 160.946 122.320 154.103 1.00 71.07  ? 621  THR A N     1 
ATOM   48   C  CA    . THR A 1 276  ? 161.170 121.666 155.376 1.00 72.45  ? 621  THR A CA    1 
ATOM   49   C  C     . THR A 1 276  ? 159.898 120.947 155.818 1.00 74.37  ? 621  THR A C     1 
ATOM   50   O  O     . THR A 1 276  ? 158.805 121.183 155.298 1.00 72.57  ? 621  THR A O     1 
ATOM   51   C  CB    . THR A 1 276  ? 161.608 122.681 156.427 1.00 65.96  ? 621  THR A CB    1 
ATOM   52   O  OG1   . THR A 1 276  ? 160.685 123.776 156.442 1.00 55.84  ? 621  THR A OG1   1 
ATOM   53   C  CG2   . THR A 1 276  ? 162.989 123.206 156.106 1.00 68.10  ? 621  THR A CG2   1 
ATOM   54   N  N     . LYS A 1 277  ? 160.055 120.049 156.793 1.00 78.84  ? 622  LYS A N     1 
ATOM   55   C  CA    . LYS A 1 277  ? 158.911 119.292 157.289 1.00 75.11  ? 622  LYS A CA    1 
ATOM   56   C  C     . LYS A 1 277  ? 157.857 120.222 157.874 1.00 76.49  ? 622  LYS A C     1 
ATOM   57   O  O     . LYS A 1 277  ? 156.651 119.991 157.717 1.00 78.42  ? 622  LYS A O     1 
ATOM   58   C  CB    . LYS A 1 277  ? 159.378 118.281 158.336 1.00 75.50  ? 622  LYS A CB    1 
ATOM   59   C  CG    . LYS A 1 277  ? 159.776 116.930 157.768 1.00 79.22  ? 622  LYS A CG    1 
ATOM   60   C  CD    . LYS A 1 277  ? 160.663 116.166 158.739 1.00 79.24  ? 622  LYS A CD    1 
ATOM   61   C  CE    . LYS A 1 277  ? 162.121 116.562 158.580 1.00 78.98  ? 622  LYS A CE    1 
ATOM   62   N  NZ    . LYS A 1 277  ? 163.026 115.657 159.339 1.00 79.18  ? 622  LYS A NZ    1 
ATOM   63   N  N     . LEU A 1 278  ? 158.302 121.286 158.542 1.00 72.53  ? 623  LEU A N     1 
ATOM   64   C  CA    . LEU A 1 278  ? 157.382 122.240 159.151 1.00 73.33  ? 623  LEU A CA    1 
ATOM   65   C  C     . LEU A 1 278  ? 156.466 122.869 158.107 1.00 75.31  ? 623  LEU A C     1 
ATOM   66   O  O     . LEU A 1 278  ? 155.242 122.889 158.271 1.00 73.98  ? 623  LEU A O     1 
ATOM   67   C  CB    . LEU A 1 278  ? 158.189 123.304 159.899 1.00 69.81  ? 623  LEU A CB    1 
ATOM   68   C  CG    . LEU A 1 278  ? 157.608 124.183 161.008 1.00 67.98  ? 623  LEU A CG    1 
ATOM   69   C  CD1   . LEU A 1 278  ? 158.637 125.212 161.420 1.00 69.72  ? 623  LEU A CD1   1 
ATOM   70   C  CD2   . LEU A 1 278  ? 156.345 124.888 160.572 1.00 68.89  ? 623  LEU A CD2   1 
ATOM   71   N  N     . VAL A 1 279  ? 157.045 123.389 157.024 1.00 74.27  ? 624  VAL A N     1 
ATOM   72   C  CA    . VAL A 1 279  ? 156.246 124.059 156.003 1.00 66.35  ? 624  VAL A CA    1 
ATOM   73   C  C     . VAL A 1 279  ? 155.406 123.050 155.229 1.00 70.36  ? 624  VAL A C     1 
ATOM   74   O  O     . VAL A 1 279  ? 154.244 123.311 154.898 1.00 69.93  ? 624  VAL A O     1 
ATOM   75   C  CB    . VAL A 1 279  ? 157.161 124.875 155.075 1.00 62.74  ? 624  VAL A CB    1 
ATOM   76   C  CG1   . VAL A 1 279  ? 156.346 125.595 154.030 1.00 66.45  ? 624  VAL A CG1   1 
ATOM   77   C  CG2   . VAL A 1 279  ? 157.971 125.861 155.883 1.00 67.46  ? 624  VAL A CG2   1 
ATOM   78   N  N     . TYR A 1 280  ? 155.981 121.884 154.927 1.00 78.59  ? 625  TYR A N     1 
ATOM   79   C  CA    . TYR A 1 280  ? 155.247 120.858 154.196 1.00 76.83  ? 625  TYR A CA    1 
ATOM   80   C  C     . TYR A 1 280  ? 154.026 120.379 154.968 1.00 74.45  ? 625  TYR A C     1 
ATOM   81   O  O     . TYR A 1 280  ? 153.005 120.039 154.360 1.00 73.90  ? 625  TYR A O     1 
ATOM   82   C  CB    . TYR A 1 280  ? 156.172 119.681 153.885 1.00 76.76  ? 625  TYR A CB    1 
ATOM   83   C  CG    . TYR A 1 280  ? 155.494 118.523 153.195 1.00 77.33  ? 625  TYR A CG    1 
ATOM   84   C  CD1   . TYR A 1 280  ? 154.644 118.732 152.120 1.00 78.04  ? 625  TYR A CD1   1 
ATOM   85   C  CD2   . TYR A 1 280  ? 155.706 117.219 153.618 1.00 80.76  ? 625  TYR A CD2   1 
ATOM   86   C  CE1   . TYR A 1 280  ? 154.022 117.677 151.486 1.00 80.91  ? 625  TYR A CE1   1 
ATOM   87   C  CE2   . TYR A 1 280  ? 155.088 116.157 152.989 1.00 78.69  ? 625  TYR A CE2   1 
ATOM   88   C  CZ    . TYR A 1 280  ? 154.248 116.393 151.924 1.00 79.52  ? 625  TYR A CZ    1 
ATOM   89   O  OH    . TYR A 1 280  ? 153.630 115.339 151.294 1.00 81.08  ? 625  TYR A OH    1 
ATOM   90   N  N     . GLN A 1 281  ? 154.105 120.349 156.301 1.00 74.14  ? 626  GLN A N     1 
ATOM   91   C  CA    . GLN A 1 281  ? 152.987 119.840 157.090 1.00 76.72  ? 626  GLN A CA    1 
ATOM   92   C  C     . GLN A 1 281  ? 151.732 120.687 156.919 1.00 77.36  ? 626  GLN A C     1 
ATOM   93   O  O     . GLN A 1 281  ? 150.617 120.186 157.104 1.00 76.47  ? 626  GLN A O     1 
ATOM   94   C  CB    . GLN A 1 281  ? 153.380 119.768 158.565 1.00 74.42  ? 626  GLN A CB    1 
ATOM   95   C  CG    . GLN A 1 281  ? 152.568 118.774 159.375 1.00 78.32  ? 626  GLN A CG    1 
ATOM   96   C  CD    . GLN A 1 281  ? 152.772 117.345 158.914 1.00 83.06  ? 626  GLN A CD    1 
ATOM   97   O  OE1   . GLN A 1 281  ? 153.904 116.885 158.764 1.00 81.12  ? 626  GLN A OE1   1 
ATOM   98   N  NE2   . GLN A 1 281  ? 151.674 116.636 158.683 1.00 81.74  ? 626  GLN A NE2   1 
ATOM   99   N  N     . ILE A 1 282  ? 151.884 121.961 156.566 1.00 72.87  ? 627  ILE A N     1 
ATOM   100  C  CA    . ILE A 1 282  ? 150.734 122.851 156.435 1.00 71.73  ? 627  ILE A CA    1 
ATOM   101  C  C     . ILE A 1 282  ? 150.258 122.944 154.991 1.00 73.10  ? 627  ILE A C     1 
ATOM   102  O  O     . ILE A 1 282  ? 149.054 122.913 154.727 1.00 74.22  ? 627  ILE A O     1 
ATOM   103  C  CB    . ILE A 1 282  ? 151.077 124.240 157.007 1.00 65.69  ? 627  ILE A CB    1 
ATOM   104  C  CG1   . ILE A 1 282  ? 151.433 124.128 158.489 1.00 68.63  ? 627  ILE A CG1   1 
ATOM   105  C  CG2   . ILE A 1 282  ? 149.914 125.192 156.821 1.00 65.70  ? 627  ILE A CG2   1 
ATOM   106  C  CD1   . ILE A 1 282  ? 152.595 124.993 158.909 1.00 69.45  ? 627  ILE A CD1   1 
ATOM   107  N  N     . PHE A 1 283  ? 151.183 123.052 154.037 1.00 72.87  ? 628  PHE A N     1 
ATOM   108  C  CA    . PHE A 1 283  ? 150.848 123.162 152.624 1.00 71.53  ? 628  PHE A CA    1 
ATOM   109  C  C     . PHE A 1 283  ? 150.613 121.808 151.965 1.00 74.84  ? 628  PHE A C     1 
ATOM   110  O  O     . PHE A 1 283  ? 150.592 121.725 150.732 1.00 73.22  ? 628  PHE A O     1 
ATOM   111  C  CB    . PHE A 1 283  ? 151.953 123.912 151.880 1.00 66.17  ? 628  PHE A CB    1 
ATOM   112  C  CG    . PHE A 1 283  ? 151.859 125.401 151.997 1.00 66.37  ? 628  PHE A CG    1 
ATOM   113  C  CD1   . PHE A 1 283  ? 150.843 126.095 151.366 1.00 73.68  ? 628  PHE A CD1   1 
ATOM   114  C  CD2   . PHE A 1 283  ? 152.790 126.108 152.732 1.00 62.45  ? 628  PHE A CD2   1 
ATOM   115  C  CE1   . PHE A 1 283  ? 150.759 127.466 151.471 1.00 75.75  ? 628  PHE A CE1   1 
ATOM   116  C  CE2   . PHE A 1 283  ? 152.709 127.476 152.839 1.00 63.40  ? 628  PHE A CE2   1 
ATOM   117  C  CZ    . PHE A 1 283  ? 151.694 128.157 152.210 1.00 69.21  ? 628  PHE A CZ    1 
ATOM   118  N  N     . ASP A 1 284  ? 150.440 120.749 152.756 1.00 86.42  ? 629  ASP A N     1 
ATOM   119  C  CA    . ASP A 1 284  ? 150.307 119.410 152.191 1.00 80.74  ? 629  ASP A CA    1 
ATOM   120  C  C     . ASP A 1 284  ? 149.042 119.276 151.353 1.00 80.47  ? 629  ASP A C     1 
ATOM   121  O  O     . ASP A 1 284  ? 149.060 118.638 150.294 1.00 82.33  ? 629  ASP A O     1 
ATOM   122  C  CB    . ASP A 1 284  ? 150.323 118.371 153.312 1.00 84.34  ? 629  ASP A CB    1 
ATOM   123  C  CG    . ASP A 1 284  ? 149.747 117.037 152.882 1.00 85.73  ? 629  ASP A CG    1 
ATOM   124  O  OD1   . ASP A 1 284  ? 150.513 116.195 152.369 1.00 83.96  ? 629  ASP A OD1   1 
ATOM   125  O  OD2   . ASP A 1 284  ? 148.529 116.826 153.064 1.00 86.73  ? 629  ASP A OD2   1 
ATOM   126  N  N     . THR A 1 285  ? 147.936 119.867 151.805 1.00 83.00  ? 630  THR A N     1 
ATOM   127  C  CA    . THR A 1 285  ? 146.656 119.643 151.143 1.00 83.45  ? 630  THR A CA    1 
ATOM   128  C  C     . THR A 1 285  ? 146.497 120.510 149.898 1.00 85.20  ? 630  THR A C     1 
ATOM   129  O  O     . THR A 1 285  ? 146.085 120.017 148.843 1.00 87.31  ? 630  THR A O     1 
ATOM   130  C  CB    . THR A 1 285  ? 145.508 119.901 152.119 1.00 86.37  ? 630  THR A CB    1 
ATOM   131  O  OG1   . THR A 1 285  ? 145.812 119.304 153.385 1.00 87.29  ? 630  THR A OG1   1 
ATOM   132  C  CG2   . THR A 1 285  ? 144.213 119.308 151.585 1.00 84.93  ? 630  THR A CG2   1 
ATOM   133  N  N     . PHE A 1 286  ? 146.807 121.803 150.005 1.00 85.61  ? 631  PHE A N     1 
ATOM   134  C  CA    . PHE A 1 286  ? 146.574 122.721 148.892 1.00 86.06  ? 631  PHE A CA    1 
ATOM   135  C  C     . PHE A 1 286  ? 147.416 122.345 147.678 1.00 86.59  ? 631  PHE A C     1 
ATOM   136  O  O     . PHE A 1 286  ? 146.885 121.968 146.628 1.00 88.13  ? 631  PHE A O     1 
ATOM   137  C  CB    . PHE A 1 286  ? 146.865 124.157 149.331 1.00 84.22  ? 631  PHE A CB    1 
ATOM   138  C  CG    . PHE A 1 286  ? 146.105 125.192 148.554 1.00 85.12  ? 631  PHE A CG    1 
ATOM   139  C  CD1   . PHE A 1 286  ? 144.726 125.256 148.628 1.00 85.57  ? 631  PHE A CD1   1 
ATOM   140  C  CD2   . PHE A 1 286  ? 146.770 126.101 147.753 1.00 86.63  ? 631  PHE A CD2   1 
ATOM   141  C  CE1   . PHE A 1 286  ? 144.025 126.208 147.915 1.00 86.43  ? 631  PHE A CE1   1 
ATOM   142  C  CE2   . PHE A 1 286  ? 146.074 127.054 147.038 1.00 87.11  ? 631  PHE A CE2   1 
ATOM   143  C  CZ    . PHE A 1 286  ? 144.700 127.107 147.120 1.00 86.39  ? 631  PHE A CZ    1 
ATOM   144  N  N     . PHE A 1 287  ? 148.737 122.436 147.806 1.00 86.18  ? 632  PHE A N     1 
ATOM   145  C  CA    . PHE A 1 287  ? 149.644 122.091 146.712 1.00 85.52  ? 632  PHE A CA    1 
ATOM   146  C  C     . PHE A 1 287  ? 150.081 120.630 146.828 1.00 86.74  ? 632  PHE A C     1 
ATOM   147  O  O     . PHE A 1 287  ? 151.253 120.307 147.015 1.00 86.94  ? 632  PHE A O     1 
ATOM   148  C  CB    . PHE A 1 287  ? 150.844 123.029 146.702 1.00 84.28  ? 632  PHE A CB    1 
ATOM   149  C  CG    . PHE A 1 287  ? 150.502 124.451 146.373 1.00 87.88  ? 632  PHE A CG    1 
ATOM   150  C  CD1   . PHE A 1 287  ? 149.862 124.767 145.188 1.00 87.96  ? 632  PHE A CD1   1 
ATOM   151  C  CD2   . PHE A 1 287  ? 150.830 125.474 147.245 1.00 84.91  ? 632  PHE A CD2   1 
ATOM   152  C  CE1   . PHE A 1 287  ? 149.550 126.076 144.883 1.00 83.76  ? 632  PHE A CE1   1 
ATOM   153  C  CE2   . PHE A 1 287  ? 150.520 126.783 146.945 1.00 83.30  ? 632  PHE A CE2   1 
ATOM   154  C  CZ    . PHE A 1 287  ? 149.879 127.084 145.762 1.00 83.92  ? 632  PHE A CZ    1 
ATOM   155  N  N     . ALA A 1 288  ? 149.094 119.738 146.714 1.00 98.90  ? 633  ALA A N     1 
ATOM   156  C  CA    . ALA A 1 288  ? 149.356 118.316 146.908 1.00 100.85 ? 633  ALA A CA    1 
ATOM   157  C  C     . ALA A 1 288  ? 150.322 117.775 145.861 1.00 103.74 ? 633  ALA A C     1 
ATOM   158  O  O     . ALA A 1 288  ? 151.241 117.016 146.188 1.00 103.81 ? 633  ALA A O     1 
ATOM   159  C  CB    . ALA A 1 288  ? 148.043 117.534 146.879 1.00 96.78  ? 633  ALA A CB    1 
ATOM   160  N  N     . GLU A 1 289  ? 150.135 118.157 144.600 1.00 102.94 ? 634  GLU A N     1 
ATOM   161  C  CA    . GLU A 1 289  ? 150.942 117.638 143.505 1.00 99.40  ? 634  GLU A CA    1 
ATOM   162  C  C     . GLU A 1 289  ? 152.091 118.557 143.115 1.00 98.52  ? 634  GLU A C     1 
ATOM   163  O  O     . GLU A 1 289  ? 152.806 118.252 142.155 1.00 100.84 ? 634  GLU A O     1 
ATOM   164  C  CB    . GLU A 1 289  ? 150.059 117.376 142.280 1.00 99.83  ? 634  GLU A CB    1 
ATOM   165  C  CG    . GLU A 1 289  ? 148.869 116.466 142.550 1.00 103.55 ? 634  GLU A CG    1 
ATOM   166  C  CD    . GLU A 1 289  ? 147.639 117.223 143.015 1.00 105.15 ? 634  GLU A CD    1 
ATOM   167  O  OE1   . GLU A 1 289  ? 147.784 118.376 143.472 1.00 105.42 ? 634  GLU A OE1   1 
ATOM   168  O  OE2   . GLU A 1 289  ? 146.526 116.664 142.923 1.00 105.99 ? 634  GLU A OE2   1 
ATOM   169  N  N     . GLN A 1 290  ? 152.287 119.667 143.823 1.00 97.06  ? 635  GLN A N     1 
ATOM   170  C  CA    . GLN A 1 290  ? 153.327 120.629 143.485 1.00 99.83  ? 635  GLN A CA    1 
ATOM   171  C  C     . GLN A 1 290  ? 154.471 120.659 144.488 1.00 102.74 ? 635  GLN A C     1 
ATOM   172  O  O     . GLN A 1 290  ? 155.423 121.422 144.293 1.00 102.07 ? 635  GLN A O     1 
ATOM   173  C  CB    . GLN A 1 290  ? 152.726 122.034 143.351 1.00 94.97  ? 635  GLN A CB    1 
ATOM   174  C  CG    . GLN A 1 290  ? 152.027 122.299 142.026 1.00 93.53  ? 635  GLN A CG    1 
ATOM   175  C  CD    . GLN A 1 290  ? 150.826 121.404 141.802 1.00 98.22  ? 635  GLN A CD    1 
ATOM   176  O  OE1   . GLN A 1 290  ? 150.897 120.425 141.060 1.00 101.24 ? 635  GLN A OE1   1 
ATOM   177  N  NE2   . GLN A 1 290  ? 149.712 121.736 142.443 1.00 97.11  ? 635  GLN A NE2   1 
ATOM   178  N  N     . ILE A 1 291  ? 154.410 119.863 145.553 1.00 96.85  ? 636  ILE A N     1 
ATOM   179  C  CA    . ILE A 1 291  ? 155.472 119.803 146.550 1.00 94.37  ? 636  ILE A CA    1 
ATOM   180  C  C     . ILE A 1 291  ? 155.908 118.358 146.733 1.00 94.42  ? 636  ILE A C     1 
ATOM   181  O  O     . ILE A 1 291  ? 155.078 117.443 146.749 1.00 93.96  ? 636  ILE A O     1 
ATOM   182  C  CB    . ILE A 1 291  ? 155.043 120.398 147.908 1.00 94.81  ? 636  ILE A CB    1 
ATOM   183  C  CG1   . ILE A 1 291  ? 154.097 121.583 147.727 1.00 92.12  ? 636  ILE A CG1   1 
ATOM   184  C  CG2   . ILE A 1 291  ? 156.258 120.805 148.711 1.00 94.93  ? 636  ILE A CG2   1 
ATOM   185  C  CD1   . ILE A 1 291  ? 153.296 121.891 148.966 1.00 92.82  ? 636  ILE A CD1   1 
ATOM   186  N  N     . GLU A 1 292  ? 157.215 118.159 146.870 1.00 97.80  ? 637  GLU A N     1 
ATOM   187  C  CA    . GLU A 1 292  ? 157.792 116.867 147.207 1.00 100.14 ? 637  GLU A CA    1 
ATOM   188  C  C     . GLU A 1 292  ? 158.330 116.915 148.631 1.00 102.22 ? 637  GLU A C     1 
ATOM   189  O  O     . GLU A 1 292  ? 158.952 117.902 149.036 1.00 100.34 ? 637  GLU A O     1 
ATOM   190  C  CB    . GLU A 1 292  ? 158.906 116.488 146.229 1.00 100.70 ? 637  GLU A CB    1 
ATOM   191  C  CG    . GLU A 1 292  ? 159.812 117.641 145.834 1.00 99.68  ? 637  GLU A CG    1 
ATOM   192  C  CD    . GLU A 1 292  ? 161.030 117.759 146.726 1.00 101.99 ? 637  GLU A CD    1 
ATOM   193  O  OE1   . GLU A 1 292  ? 161.355 116.776 147.424 1.00 101.56 ? 637  GLU A OE1   1 
ATOM   194  O  OE2   . GLU A 1 292  ? 161.666 118.832 146.726 1.00 101.44 ? 637  GLU A OE2   1 
ATOM   195  N  N     . LYS A 1 293  ? 158.077 115.847 149.386 1.00 102.76 ? 638  LYS A N     1 
ATOM   196  C  CA    . LYS A 1 293  ? 158.442 115.817 150.797 1.00 102.27 ? 638  LYS A CA    1 
ATOM   197  C  C     . LYS A 1 293  ? 159.950 115.937 150.976 1.00 105.13 ? 638  LYS A C     1 
ATOM   198  O  O     . LYS A 1 293  ? 160.732 115.281 150.282 1.00 102.92 ? 638  LYS A O     1 
ATOM   199  C  CB    . LYS A 1 293  ? 157.942 114.523 151.440 1.00 100.93 ? 638  LYS A CB    1 
ATOM   200  C  CG    . LYS A 1 293  ? 158.295 114.380 152.909 1.00 99.59  ? 638  LYS A CG    1 
ATOM   201  C  CD    . LYS A 1 293  ? 158.178 112.934 153.361 1.00 100.17 ? 638  LYS A CD    1 
ATOM   202  C  CE    . LYS A 1 293  ? 158.927 112.004 152.421 1.00 99.90  ? 638  LYS A CE    1 
ATOM   203  N  NZ    . LYS A 1 293  ? 158.711 110.573 152.767 1.00 102.59 ? 638  LYS A NZ    1 
ATOM   204  N  N     . ASP A 1 294  ? 160.355 116.782 151.919 1.00 105.04 ? 639  ASP A N     1 
ATOM   205  C  CA    . ASP A 1 294  ? 161.767 116.967 152.235 1.00 105.74 ? 639  ASP A CA    1 
ATOM   206  C  C     . ASP A 1 294  ? 161.945 117.457 153.668 1.00 102.05 ? 639  ASP A C     1 
ATOM   207  O  O     . ASP A 1 294  ? 162.935 118.111 153.991 1.00 103.19 ? 639  ASP A O     1 
ATOM   208  C  CB    . ASP A 1 294  ? 162.416 117.950 151.259 1.00 105.42 ? 639  ASP A CB    1 
ATOM   209  C  CG    . ASP A 1 294  ? 163.859 117.602 150.956 1.00 105.34 ? 639  ASP A CG    1 
ATOM   210  O  OD1   . ASP A 1 294  ? 164.199 116.401 150.987 1.00 102.85 ? 639  ASP A OD1   1 
ATOM   211  O  OD2   . ASP A 1 294  ? 164.654 118.527 150.691 1.00 105.10 ? 639  ASP A OD2   1 
ATOM   212  N  N     . GLN A 1 375  ? 130.140 141.083 174.958 1.00 110.80 ? 720  GLN A N     1 
ATOM   213  C  CA    . GLN A 1 375  ? 129.603 139.795 174.535 1.00 112.79 ? 720  GLN A CA    1 
ATOM   214  C  C     . GLN A 1 375  ? 128.172 139.605 175.023 1.00 111.24 ? 720  GLN A C     1 
ATOM   215  O  O     . GLN A 1 375  ? 127.659 140.407 175.803 1.00 110.94 ? 720  GLN A O     1 
ATOM   216  C  CB    . GLN A 1 375  ? 130.490 138.655 175.038 1.00 113.45 ? 720  GLN A CB    1 
ATOM   217  C  CG    . GLN A 1 375  ? 131.512 138.171 174.021 1.00 112.09 ? 720  GLN A CG    1 
ATOM   218  C  CD    . GLN A 1 375  ? 132.440 139.274 173.556 1.00 111.64 ? 720  GLN A CD    1 
ATOM   219  O  OE1   . GLN A 1 375  ? 132.822 140.150 174.332 1.00 109.92 ? 720  GLN A OE1   1 
ATOM   220  N  NE2   . GLN A 1 375  ? 132.805 139.239 172.279 1.00 110.04 ? 720  GLN A NE2   1 
ATOM   221  N  N     . GLY A 1 376  ? 127.531 138.534 174.559 1.00 120.24 ? 721  GLY A N     1 
ATOM   222  C  CA    . GLY A 1 376  ? 126.151 138.270 174.897 1.00 121.76 ? 721  GLY A CA    1 
ATOM   223  C  C     . GLY A 1 376  ? 125.983 137.709 176.295 1.00 123.11 ? 721  GLY A C     1 
ATOM   224  O  O     . GLY A 1 376  ? 126.940 137.472 177.033 1.00 123.84 ? 721  GLY A O     1 
ATOM   225  N  N     . LYS A 1 377  ? 124.722 137.501 176.663 1.00 129.16 ? 722  LYS A N     1 
ATOM   226  C  CA    . LYS A 1 377  ? 124.401 136.943 177.967 1.00 128.99 ? 722  LYS A CA    1 
ATOM   227  C  C     . LYS A 1 377  ? 124.831 135.483 178.048 1.00 129.33 ? 722  LYS A C     1 
ATOM   228  O  O     . LYS A 1 377  ? 124.917 134.778 177.039 1.00 129.72 ? 722  LYS A O     1 
ATOM   229  C  CB    . LYS A 1 377  ? 122.904 137.067 178.247 1.00 127.27 ? 722  LYS A CB    1 
ATOM   230  C  CG    . LYS A 1 377  ? 122.047 137.174 176.996 1.00 127.66 ? 722  LYS A CG    1 
ATOM   231  C  CD    . LYS A 1 377  ? 120.635 137.628 177.332 1.00 128.09 ? 722  LYS A CD    1 
ATOM   232  C  CE    . LYS A 1 377  ? 119.829 137.903 176.073 1.00 128.79 ? 722  LYS A CE    1 
ATOM   233  N  NZ    . LYS A 1 377  ? 118.466 138.414 176.387 1.00 128.04 ? 722  LYS A NZ    1 
ATOM   234  N  N     . LYS A 1 378  ? 125.109 135.033 179.268 1.00 126.42 ? 723  LYS A N     1 
ATOM   235  C  CA    . LYS A 1 378  ? 125.570 133.678 179.524 1.00 126.84 ? 723  LYS A CA    1 
ATOM   236  C  C     . LYS A 1 378  ? 124.664 133.002 180.544 1.00 127.76 ? 723  LYS A C     1 
ATOM   237  O  O     . LYS A 1 378  ? 123.894 133.654 181.255 1.00 127.32 ? 723  LYS A O     1 
ATOM   238  C  CB    . LYS A 1 378  ? 127.019 133.671 180.023 1.00 126.09 ? 723  LYS A CB    1 
ATOM   239  C  CG    . LYS A 1 378  ? 127.913 134.677 179.320 1.00 125.59 ? 723  LYS A CG    1 
ATOM   240  C  CD    . LYS A 1 378  ? 128.499 134.102 178.043 1.00 126.67 ? 723  LYS A CD    1 
ATOM   241  C  CE    . LYS A 1 378  ? 129.199 135.173 177.225 1.00 124.68 ? 723  LYS A CE    1 
ATOM   242  N  NZ    . LYS A 1 378  ? 130.045 136.056 178.073 1.00 124.17 ? 723  LYS A NZ    1 
ATOM   243  N  N     . LYS A 1 379  ? 124.765 131.677 180.607 1.00 132.97 ? 724  LYS A N     1 
ATOM   244  C  CA    . LYS A 1 379  ? 123.918 130.863 181.468 1.00 132.96 ? 724  LYS A CA    1 
ATOM   245  C  C     . LYS A 1 379  ? 124.659 130.518 182.753 1.00 132.34 ? 724  LYS A C     1 
ATOM   246  O  O     . LYS A 1 379  ? 125.811 130.075 182.712 1.00 131.52 ? 724  LYS A O     1 
ATOM   247  C  CB    . LYS A 1 379  ? 123.484 129.585 180.749 1.00 132.67 ? 724  LYS A CB    1 
ATOM   248  C  CG    . LYS A 1 379  ? 122.501 129.819 179.615 1.00 133.40 ? 724  LYS A CG    1 
ATOM   249  C  CD    . LYS A 1 379  ? 121.741 128.549 179.275 1.00 133.70 ? 724  LYS A CD    1 
ATOM   250  C  CE    . LYS A 1 379  ? 120.443 128.863 178.552 1.00 134.00 ? 724  LYS A CE    1 
ATOM   251  N  NZ    . LYS A 1 379  ? 119.712 129.993 179.191 1.00 133.69 ? 724  LYS A NZ    1 
ATOM   252  N  N     . LYS A 1 380  ? 123.995 130.724 183.887 1.00 129.01 ? 725  LYS A N     1 
ATOM   253  C  CA    . LYS A 1 380  ? 124.590 130.413 185.178 1.00 128.87 ? 725  LYS A CA    1 
ATOM   254  C  C     . LYS A 1 380  ? 124.734 128.906 185.359 1.00 128.39 ? 725  LYS A C     1 
ATOM   255  O  O     . LYS A 1 380  ? 123.989 128.112 184.778 1.00 129.56 ? 725  LYS A O     1 
ATOM   256  C  CB    . LYS A 1 380  ? 123.745 130.994 186.312 1.00 129.53 ? 725  LYS A CB    1 
ATOM   257  C  CG    . LYS A 1 380  ? 123.857 132.502 186.468 1.00 128.32 ? 725  LYS A CG    1 
ATOM   258  C  CD    . LYS A 1 380  ? 122.707 133.218 185.780 1.00 127.77 ? 725  LYS A CD    1 
ATOM   259  C  CE    . LYS A 1 380  ? 122.802 134.723 185.975 1.00 127.30 ? 725  LYS A CE    1 
ATOM   260  N  NZ    . LYS A 1 380  ? 121.747 135.449 185.215 1.00 127.70 ? 725  LYS A NZ    1 
ATOM   261  N  N     . GLN A 1 381  ? 125.706 128.517 186.177 1.00 126.63 ? 726  GLN A N     1 
ATOM   262  C  CA    . GLN A 1 381  ? 125.940 127.108 186.472 1.00 128.35 ? 726  GLN A CA    1 
ATOM   263  C  C     . GLN A 1 381  ? 125.638 126.797 187.935 1.00 128.92 ? 726  GLN A C     1 
ATOM   264  O  O     . GLN A 1 381  ? 124.685 126.082 188.244 1.00 128.11 ? 726  GLN A O     1 
ATOM   265  C  CB    . GLN A 1 381  ? 127.382 126.722 186.140 1.00 127.50 ? 726  GLN A CB    1 
ATOM   266  C  CG    . GLN A 1 381  ? 127.797 127.058 184.719 1.00 127.34 ? 726  GLN A CG    1 
ATOM   267  C  CD    . GLN A 1 381  ? 126.991 126.301 183.685 1.00 128.71 ? 726  GLN A CD    1 
ATOM   268  O  OE1   . GLN A 1 381  ? 127.211 125.111 183.458 1.00 128.52 ? 726  GLN A OE1   1 
ATOM   269  N  NE2   . GLN A 1 381  ? 126.049 126.988 183.050 1.00 128.19 ? 726  GLN A NE2   1 
ATOM   270  N  N     . ILE A 1 386  ? 131.262 127.620 194.204 1.00 140.06 ? 731  ILE A N     1 
ATOM   271  C  CA    . ILE A 1 386  ? 130.116 128.133 194.942 1.00 140.88 ? 731  ILE A CA    1 
ATOM   272  C  C     . ILE A 1 386  ? 130.461 128.269 196.419 1.00 141.41 ? 731  ILE A C     1 
ATOM   273  O  O     . ILE A 1 386  ? 129.584 128.208 197.279 1.00 141.95 ? 731  ILE A O     1 
ATOM   274  C  CB    . ILE A 1 386  ? 128.883 127.234 194.750 1.00 141.17 ? 731  ILE A CB    1 
ATOM   275  C  CG1   . ILE A 1 386  ? 129.291 125.760 194.765 1.00 140.36 ? 731  ILE A CG1   1 
ATOM   276  C  CG2   . ILE A 1 386  ? 128.171 127.580 193.452 1.00 140.20 ? 731  ILE A CG2   1 
ATOM   277  C  CD1   . ILE A 1 386  ? 128.147 124.805 194.502 1.00 139.58 ? 731  ILE A CD1   1 
ATOM   278  N  N     . SER A 1 387  ? 131.748 128.452 196.707 1.00 140.68 ? 732  SER A N     1 
ATOM   279  C  CA    . SER A 1 387  ? 132.211 128.599 198.078 1.00 141.05 ? 732  SER A CA    1 
ATOM   280  C  C     . SER A 1 387  ? 133.466 129.458 198.089 1.00 141.08 ? 732  SER A C     1 
ATOM   281  O  O     . SER A 1 387  ? 134.171 129.576 197.085 1.00 140.95 ? 732  SER A O     1 
ATOM   282  C  CB    . SER A 1 387  ? 132.485 127.237 198.727 1.00 140.39 ? 732  SER A CB    1 
ATOM   283  O  OG    . SER A 1 387  ? 131.291 126.485 198.856 1.00 140.68 ? 732  SER A OG    1 
ATOM   284  N  N     . TRP A 1 388  ? 133.739 130.056 199.245 1.00 140.60 ? 733  TRP A N     1 
ATOM   285  C  CA    . TRP A 1 388  ? 134.905 130.907 199.418 1.00 139.61 ? 733  TRP A CA    1 
ATOM   286  C  C     . TRP A 1 388  ? 136.110 130.061 199.826 1.00 140.95 ? 733  TRP A C     1 
ATOM   287  O  O     . TRP A 1 388  ? 136.082 128.828 199.774 1.00 141.42 ? 733  TRP A O     1 
ATOM   288  C  CB    . TRP A 1 388  ? 134.617 132.001 200.444 1.00 139.69 ? 733  TRP A CB    1 
ATOM   289  C  CG    . TRP A 1 388  ? 134.502 133.373 199.851 1.00 141.31 ? 733  TRP A CG    1 
ATOM   290  C  CD1   . TRP A 1 388  ? 133.405 134.183 199.868 1.00 142.32 ? 733  TRP A CD1   1 
ATOM   291  C  CD2   . TRP A 1 388  ? 135.523 134.095 199.153 1.00 141.04 ? 733  TRP A CD2   1 
ATOM   292  N  NE1   . TRP A 1 388  ? 133.680 135.365 199.226 1.00 141.87 ? 733  TRP A NE1   1 
ATOM   293  C  CE2   . TRP A 1 388  ? 134.974 135.336 198.777 1.00 141.86 ? 733  TRP A CE2   1 
ATOM   294  C  CE3   . TRP A 1 388  ? 136.848 133.814 198.809 1.00 140.65 ? 733  TRP A CE3   1 
ATOM   295  C  CZ2   . TRP A 1 388  ? 135.702 136.293 198.075 1.00 141.20 ? 733  TRP A CZ2   1 
ATOM   296  C  CZ3   . TRP A 1 388  ? 137.567 134.764 198.111 1.00 140.12 ? 733  TRP A CZ3   1 
ATOM   297  C  CH2   . TRP A 1 388  ? 136.994 135.988 197.753 1.00 140.21 ? 733  TRP A CH2   1 
ATOM   298  N  N     . VAL A 1 389  ? 137.189 130.724 200.230 1.00 138.02 ? 734  VAL A N     1 
ATOM   299  C  CA    . VAL A 1 389  ? 138.386 130.042 200.703 1.00 137.22 ? 734  VAL A CA    1 
ATOM   300  C  C     . VAL A 1 389  ? 138.114 129.355 202.035 1.00 137.65 ? 734  VAL A C     1 
ATOM   301  O  O     . VAL A 1 389  ? 137.890 128.146 202.087 1.00 137.91 ? 734  VAL A O     1 
ATOM   302  C  CB    . VAL A 1 389  ? 139.568 131.017 200.828 1.00 135.32 ? 734  VAL A CB    1 
ATOM   303  C  CG1   . VAL A 1 389  ? 139.436 131.845 202.095 1.00 136.00 ? 734  VAL A CG1   1 
ATOM   304  C  CG2   . VAL A 1 389  ? 140.879 130.255 200.836 1.00 135.09 ? 734  VAL A CG2   1 
ATOM   305  N  N     . LYS A 1 399  ? 135.901 147.766 201.397 1.00 147.73 ? 744  LYS A N     1 
ATOM   306  C  CA    . LYS A 1 399  ? 135.448 147.950 200.024 1.00 148.63 ? 744  LYS A CA    1 
ATOM   307  C  C     . LYS A 1 399  ? 135.538 146.647 199.239 1.00 148.33 ? 744  LYS A C     1 
ATOM   308  O  O     . LYS A 1 399  ? 134.542 145.944 199.068 1.00 147.36 ? 744  LYS A O     1 
ATOM   309  C  CB    . LYS A 1 399  ? 136.267 149.040 199.330 1.00 146.88 ? 744  LYS A CB    1 
ATOM   310  N  N     . SER A 1 400  ? 136.739 146.330 198.762 1.00 148.40 ? 745  SER A N     1 
ATOM   311  C  CA    . SER A 1 400  ? 136.991 145.122 197.990 1.00 148.73 ? 745  SER A CA    1 
ATOM   312  C  C     . SER A 1 400  ? 138.018 144.265 198.714 1.00 149.96 ? 745  SER A C     1 
ATOM   313  O  O     . SER A 1 400  ? 139.062 144.768 199.141 1.00 149.16 ? 745  SER A O     1 
ATOM   314  C  CB    . SER A 1 400  ? 137.480 145.460 196.580 1.00 147.36 ? 745  SER A CB    1 
ATOM   315  O  OG    . SER A 1 400  ? 136.469 146.114 195.833 1.00 146.99 ? 745  SER A OG    1 
ATOM   316  N  N     . TYR A 1 401  ? 137.719 142.976 198.850 1.00 148.23 ? 746  TYR A N     1 
ATOM   317  C  CA    . TYR A 1 401  ? 138.612 142.016 199.481 1.00 146.94 ? 746  TYR A CA    1 
ATOM   318  C  C     . TYR A 1 401  ? 139.150 141.066 198.422 1.00 145.13 ? 746  TYR A C     1 
ATOM   319  O  O     . TYR A 1 401  ? 138.374 140.434 197.698 1.00 142.62 ? 746  TYR A O     1 
ATOM   320  C  CB    . TYR A 1 401  ? 137.889 141.232 200.578 1.00 145.92 ? 746  TYR A CB    1 
ATOM   321  C  CG    . TYR A 1 401  ? 136.807 142.020 201.278 1.00 146.26 ? 746  TYR A CG    1 
ATOM   322  C  CD1   . TYR A 1 401  ? 137.125 142.967 202.242 1.00 145.38 ? 746  TYR A CD1   1 
ATOM   323  C  CD2   . TYR A 1 401  ? 135.468 141.819 200.974 1.00 146.14 ? 746  TYR A CD2   1 
ATOM   324  C  CE1   . TYR A 1 401  ? 136.139 143.690 202.886 1.00 146.14 ? 746  TYR A CE1   1 
ATOM   325  C  CE2   . TYR A 1 401  ? 134.475 142.537 201.612 1.00 146.00 ? 746  TYR A CE2   1 
ATOM   326  C  CZ    . TYR A 1 401  ? 134.816 143.472 202.566 1.00 146.73 ? 746  TYR A CZ    1 
ATOM   327  O  OH    . TYR A 1 401  ? 133.831 144.190 203.204 1.00 146.84 ? 746  TYR A OH    1 
ATOM   328  N  N     . TYR A 1 402  ? 140.473 140.964 198.337 1.00 139.35 ? 747  TYR A N     1 
ATOM   329  C  CA    . TYR A 1 402  ? 141.140 140.156 197.325 1.00 138.87 ? 747  TYR A CA    1 
ATOM   330  C  C     . TYR A 1 402  ? 141.739 138.924 197.988 1.00 140.12 ? 747  TYR A C     1 
ATOM   331  O  O     . TYR A 1 402  ? 142.548 139.044 198.915 1.00 139.05 ? 747  TYR A O     1 
ATOM   332  C  CB    . TYR A 1 402  ? 142.222 140.962 196.605 1.00 137.61 ? 747  TYR A CB    1 
ATOM   333  C  CG    . TYR A 1 402  ? 141.689 142.116 195.785 1.00 137.75 ? 747  TYR A CG    1 
ATOM   334  C  CD1   . TYR A 1 402  ? 141.275 143.294 196.392 1.00 138.41 ? 747  TYR A CD1   1 
ATOM   335  C  CD2   . TYR A 1 402  ? 141.599 142.026 194.403 1.00 137.91 ? 747  TYR A CD2   1 
ATOM   336  C  CE1   . TYR A 1 402  ? 140.787 144.350 195.646 1.00 138.53 ? 747  TYR A CE1   1 
ATOM   337  C  CE2   . TYR A 1 402  ? 141.112 143.077 193.649 1.00 138.06 ? 747  TYR A CE2   1 
ATOM   338  C  CZ    . TYR A 1 402  ? 140.708 144.235 194.275 1.00 138.93 ? 747  TYR A CZ    1 
ATOM   339  O  OH    . TYR A 1 402  ? 140.223 145.284 193.528 1.00 138.63 ? 747  TYR A OH    1 
ATOM   340  N  N     . LYS A 1 403  ? 141.344 137.746 197.511 1.00 137.29 ? 748  LYS A N     1 
ATOM   341  C  CA    . LYS A 1 403  ? 141.857 136.480 198.011 1.00 134.85 ? 748  LYS A CA    1 
ATOM   342  C  C     . LYS A 1 403  ? 142.344 135.641 196.839 1.00 134.38 ? 748  LYS A C     1 
ATOM   343  O  O     . LYS A 1 403  ? 141.825 135.744 195.724 1.00 135.74 ? 748  LYS A O     1 
ATOM   344  C  CB    . LYS A 1 403  ? 140.795 135.714 198.807 1.00 134.60 ? 748  LYS A CB    1 
ATOM   345  C  CG    . LYS A 1 403  ? 140.092 136.550 199.865 1.00 135.96 ? 748  LYS A CG    1 
ATOM   346  C  CD    . LYS A 1 403  ? 141.043 136.938 200.985 1.00 134.43 ? 748  LYS A CD    1 
ATOM   347  C  CE    . LYS A 1 403  ? 140.496 138.098 201.800 1.00 133.26 ? 748  LYS A CE    1 
ATOM   348  N  NZ    . LYS A 1 403  ? 139.128 137.816 202.316 1.00 134.06 ? 748  LYS A NZ    1 
ATOM   349  N  N     . LYS A 1 404  ? 143.350 134.808 197.105 1.00 138.43 ? 749  LYS A N     1 
ATOM   350  C  CA    . LYS A 1 404  ? 144.029 134.098 196.026 1.00 139.52 ? 749  LYS A CA    1 
ATOM   351  C  C     . LYS A 1 404  ? 143.131 133.047 195.383 1.00 139.56 ? 749  LYS A C     1 
ATOM   352  O  O     . LYS A 1 404  ? 143.040 132.969 194.152 1.00 138.69 ? 749  LYS A O     1 
ATOM   353  C  CB    . LYS A 1 404  ? 145.314 133.455 196.549 1.00 138.88 ? 749  LYS A CB    1 
ATOM   354  C  CG    . LYS A 1 404  ? 146.553 134.307 196.351 1.00 138.37 ? 749  LYS A CG    1 
ATOM   355  C  CD    . LYS A 1 404  ? 147.795 133.444 196.214 1.00 138.91 ? 749  LYS A CD    1 
ATOM   356  C  CE    . LYS A 1 404  ? 149.027 134.292 195.944 1.00 139.78 ? 749  LYS A CE    1 
ATOM   357  N  NZ    . LYS A 1 404  ? 148.843 135.170 194.757 1.00 138.61 ? 749  LYS A NZ    1 
ATOM   358  N  N     . VAL A 1 405  ? 142.459 132.228 196.191 1.00 135.08 ? 750  VAL A N     1 
ATOM   359  C  CA    . VAL A 1 405  ? 141.800 131.037 195.674 1.00 133.07 ? 750  VAL A CA    1 
ATOM   360  C  C     . VAL A 1 405  ? 140.327 131.022 196.065 1.00 131.72 ? 750  VAL A C     1 
ATOM   361  O  O     . VAL A 1 405  ? 139.872 131.755 196.946 1.00 132.81 ? 750  VAL A O     1 
ATOM   362  C  CB    . VAL A 1 405  ? 142.492 129.741 196.146 1.00 132.41 ? 750  VAL A CB    1 
ATOM   363  C  CG1   . VAL A 1 405  ? 143.955 129.737 195.735 1.00 131.03 ? 750  VAL A CG1   1 
ATOM   364  C  CG2   . VAL A 1 405  ? 142.356 129.583 197.646 1.00 132.72 ? 750  VAL A CG2   1 
ATOM   365  N  N     . CYS A 1 406  ? 139.587 130.159 195.374 1.00 134.26 ? 751  CYS A N     1 
ATOM   366  C  CA    . CYS A 1 406  ? 138.167 129.931 195.589 1.00 136.33 ? 751  CYS A CA    1 
ATOM   367  C  C     . CYS A 1 406  ? 137.871 128.471 195.276 1.00 137.61 ? 751  CYS A C     1 
ATOM   368  O  O     . CYS A 1 406  ? 138.663 127.787 194.622 1.00 137.74 ? 751  CYS A O     1 
ATOM   369  C  CB    . CYS A 1 406  ? 137.308 130.859 194.723 1.00 136.99 ? 751  CYS A CB    1 
ATOM   370  S  SG    . CYS A 1 406  ? 135.643 130.244 194.391 1.00 140.33 ? 751  CYS A SG    1 
ATOM   371  N  N     . ILE A 1 407  ? 136.725 127.994 195.750 1.00 141.43 ? 752  ILE A N     1 
ATOM   372  C  CA    . ILE A 1 407  ? 136.364 126.580 195.645 1.00 140.97 ? 752  ILE A CA    1 
ATOM   373  C  C     . ILE A 1 407  ? 135.033 126.495 194.905 1.00 139.48 ? 752  ILE A C     1 
ATOM   374  O  O     . ILE A 1 407  ? 133.957 126.572 195.505 1.00 139.35 ? 752  ILE A O     1 
ATOM   375  C  CB    . ILE A 1 407  ? 136.286 125.894 197.011 1.00 141.91 ? 752  ILE A CB    1 
ATOM   376  C  CG1   . ILE A 1 407  ? 137.561 126.155 197.817 1.00 140.77 ? 752  ILE A CG1   1 
ATOM   377  C  CG2   . ILE A 1 407  ? 136.053 124.399 196.842 1.00 141.03 ? 752  ILE A CG2   1 
ATOM   378  C  CD1   . ILE A 1 407  ? 138.793 125.486 197.246 1.00 140.26 ? 752  ILE A CD1   1 
ATOM   379  N  N     . ASP A 1 408  ? 135.101 126.334 193.588 1.00 136.98 ? 753  ASP A N     1 
ATOM   380  C  CA    . ASP A 1 408  ? 133.944 125.932 192.786 1.00 139.03 ? 753  ASP A CA    1 
ATOM   381  C  C     . ASP A 1 408  ? 134.005 124.432 192.504 1.00 139.04 ? 753  ASP A C     1 
ATOM   382  O  O     . ASP A 1 408  ? 134.016 123.983 191.357 1.00 137.72 ? 753  ASP A O     1 
ATOM   383  C  CB    . ASP A 1 408  ? 133.889 126.740 191.492 1.00 139.36 ? 753  ASP A CB    1 
ATOM   384  C  CG    . ASP A 1 408  ? 132.554 126.617 190.781 1.00 140.21 ? 753  ASP A CG    1 
ATOM   385  O  OD1   . ASP A 1 408  ? 131.655 125.928 191.307 1.00 139.80 ? 753  ASP A OD1   1 
ATOM   386  O  OD2   . ASP A 1 408  ? 132.405 127.207 189.691 1.00 139.89 ? 753  ASP A OD2   1 
ATOM   387  N  N     . ALA A 1 409  ? 134.062 123.661 193.592 1.00 137.81 ? 754  ALA A N     1 
ATOM   388  C  CA    . ALA A 1 409  ? 134.376 122.234 193.630 1.00 136.98 ? 754  ALA A CA    1 
ATOM   389  C  C     . ALA A 1 409  ? 135.818 121.960 193.220 1.00 137.73 ? 754  ALA A C     1 
ATOM   390  O  O     . ALA A 1 409  ? 136.245 120.799 193.237 1.00 136.99 ? 754  ALA A O     1 
ATOM   391  C  CB    . ALA A 1 409  ? 133.431 121.387 192.764 1.00 136.30 ? 754  ALA A CB    1 
ATOM   392  N  N     . GLU A 1 410  ? 136.581 122.990 192.858 1.00 139.62 ? 755  GLU A N     1 
ATOM   393  C  CA    . GLU A 1 410  ? 137.995 122.878 192.537 1.00 138.05 ? 755  GLU A CA    1 
ATOM   394  C  C     . GLU A 1 410  ? 138.696 124.134 193.032 1.00 136.67 ? 755  GLU A C     1 
ATOM   395  O  O     . GLU A 1 410  ? 138.065 125.167 193.271 1.00 137.07 ? 755  GLU A O     1 
ATOM   396  C  CB    . GLU A 1 410  ? 138.234 122.697 191.031 1.00 137.68 ? 755  GLU A CB    1 
ATOM   397  C  CG    . GLU A 1 410  ? 137.781 121.358 190.473 1.00 138.03 ? 755  GLU A CG    1 
ATOM   398  C  CD    . GLU A 1 410  ? 136.645 121.499 189.481 1.00 138.72 ? 755  GLU A CD    1 
ATOM   399  O  OE1   . GLU A 1 410  ? 135.546 121.929 189.891 1.00 140.04 ? 755  GLU A OE1   1 
ATOM   400  O  OE2   . GLU A 1 410  ? 136.850 121.181 188.291 1.00 137.56 ? 755  GLU A OE2   1 
ATOM   401  N  N     . THR A 1 411  ? 140.014 124.040 193.185 1.00 128.95 ? 756  THR A N     1 
ATOM   402  C  CA    . THR A 1 411  ? 140.808 125.146 193.717 1.00 129.65 ? 756  THR A CA    1 
ATOM   403  C  C     . THR A 1 411  ? 141.163 126.091 192.577 1.00 130.12 ? 756  THR A C     1 
ATOM   404  O  O     . THR A 1 411  ? 142.208 125.963 191.938 1.00 130.05 ? 756  THR A O     1 
ATOM   405  C  CB    . THR A 1 411  ? 142.057 124.626 194.416 1.00 130.13 ? 756  THR A CB    1 
ATOM   406  O  OG1   . THR A 1 411  ? 142.832 123.848 193.495 1.00 130.03 ? 756  THR A OG1   1 
ATOM   407  C  CG2   . THR A 1 411  ? 141.678 123.760 195.607 1.00 129.07 ? 756  THR A CG2   1 
ATOM   408  N  N     . LEU A 1 412  ? 140.283 127.054 192.316 1.00 128.81 ? 757  LEU A N     1 
ATOM   409  C  CA    . LEU A 1 412  ? 140.586 128.105 191.355 1.00 126.62 ? 757  LEU A CA    1 
ATOM   410  C  C     . LEU A 1 412  ? 141.489 129.141 192.006 1.00 126.61 ? 757  LEU A C     1 
ATOM   411  O  O     . LEU A 1 412  ? 141.284 129.518 193.160 1.00 128.09 ? 757  LEU A O     1 
ATOM   412  C  CB    . LEU A 1 412  ? 139.306 128.775 190.857 1.00 126.80 ? 757  LEU A CB    1 
ATOM   413  C  CG    . LEU A 1 412  ? 138.256 127.888 190.190 1.00 127.89 ? 757  LEU A CG    1 
ATOM   414  C  CD1   . LEU A 1 412  ? 136.873 128.491 190.363 1.00 125.22 ? 757  LEU A CD1   1 
ATOM   415  C  CD2   . LEU A 1 412  ? 138.578 127.693 188.719 1.00 127.18 ? 757  LEU A CD2   1 
ATOM   416  N  N     . GLU A 1 413  ? 142.490 129.600 191.265 1.00 121.19 ? 758  GLU A N     1 
ATOM   417  C  CA    . GLU A 1 413  ? 143.426 130.593 191.769 1.00 123.82 ? 758  GLU A CA    1 
ATOM   418  C  C     . GLU A 1 413  ? 143.521 131.739 190.770 1.00 124.04 ? 758  GLU A C     1 
ATOM   419  O  O     . GLU A 1 413  ? 142.728 131.839 189.830 1.00 122.77 ? 758  GLU A O     1 
ATOM   420  C  CB    . GLU A 1 413  ? 144.803 129.972 192.040 1.00 121.13 ? 758  GLU A CB    1 
ATOM   421  C  CG    . GLU A 1 413  ? 145.309 129.067 190.932 1.00 120.63 ? 758  GLU A CG    1 
ATOM   422  C  CD    . GLU A 1 413  ? 146.681 128.497 191.233 1.00 120.55 ? 758  GLU A CD    1 
ATOM   423  O  OE1   . GLU A 1 413  ? 147.423 129.117 192.024 1.00 120.02 ? 758  GLU A OE1   1 
ATOM   424  O  OE2   . GLU A 1 413  ? 147.017 127.428 190.682 1.00 122.61 ? 758  GLU A OE2   1 
ATOM   425  N  N     . VAL A 1 414  ? 144.482 132.619 190.989 1.00 121.02 ? 759  VAL A N     1 
ATOM   426  C  CA    . VAL A 1 414  ? 144.721 133.740 190.089 1.00 117.71 ? 759  VAL A CA    1 
ATOM   427  C  C     . VAL A 1 414  ? 145.854 133.378 189.140 1.00 115.20 ? 759  VAL A C     1 
ATOM   428  O  O     . VAL A 1 414  ? 146.897 132.860 189.555 1.00 116.50 ? 759  VAL A O     1 
ATOM   429  C  CB    . VAL A 1 414  ? 145.025 135.028 190.879 1.00 117.29 ? 759  VAL A CB    1 
ATOM   430  C  CG1   . VAL A 1 414  ? 143.812 135.434 191.696 1.00 115.31 ? 759  VAL A CG1   1 
ATOM   431  C  CG2   . VAL A 1 414  ? 146.226 134.836 191.790 1.00 118.96 ? 759  VAL A CG2   1 
ATOM   432  N  N     . GLY A 1 415  ? 145.638 133.629 187.852 1.00 104.28 ? 760  GLY A N     1 
ATOM   433  C  CA    . GLY A 1 415  ? 146.602 133.298 186.828 1.00 107.09 ? 760  GLY A CA    1 
ATOM   434  C  C     . GLY A 1 415  ? 146.279 132.057 186.024 1.00 109.08 ? 760  GLY A C     1 
ATOM   435  O  O     . GLY A 1 415  ? 146.904 131.839 184.979 1.00 110.93 ? 760  GLY A O     1 
ATOM   436  N  N     . ASP A 1 416  ? 145.333 131.240 186.473 1.00 102.50 ? 761  ASP A N     1 
ATOM   437  C  CA    . ASP A 1 416  ? 144.913 130.063 185.730 1.00 102.46 ? 761  ASP A CA    1 
ATOM   438  C  C     . ASP A 1 416  ? 143.635 130.364 184.957 1.00 100.79 ? 761  ASP A C     1 
ATOM   439  O  O     . ASP A 1 416  ? 142.802 131.166 185.385 1.00 103.84 ? 761  ASP A O     1 
ATOM   440  C  CB    . ASP A 1 416  ? 144.701 128.867 186.661 1.00 103.38 ? 761  ASP A CB    1 
ATOM   441  C  CG    . ASP A 1 416  ? 143.366 128.908 187.371 1.00 103.89 ? 761  ASP A CG    1 
ATOM   442  O  OD1   . ASP A 1 416  ? 142.980 129.989 187.855 1.00 102.26 ? 761  ASP A OD1   1 
ATOM   443  O  OD2   . ASP A 1 416  ? 142.700 127.856 187.442 1.00 106.03 ? 761  ASP A OD2   1 
ATOM   444  N  N     . CYS A 1 417  ? 143.491 129.717 183.808 1.00 83.24  ? 762  CYS A N     1 
ATOM   445  C  CA    . CYS A 1 417  ? 142.402 130.017 182.894 1.00 82.01  ? 762  CYS A CA    1 
ATOM   446  C  C     . CYS A 1 417  ? 141.209 129.104 183.138 1.00 81.91  ? 762  CYS A C     1 
ATOM   447  O  O     . CYS A 1 417  ? 141.355 127.937 183.509 1.00 83.75  ? 762  CYS A O     1 
ATOM   448  C  CB    . CYS A 1 417  ? 142.876 129.891 181.447 1.00 82.79  ? 762  CYS A CB    1 
ATOM   449  S  SG    . CYS A 1 417  ? 144.610 130.332 181.226 1.00 90.77  ? 762  CYS A SG    1 
ATOM   450  N  N     . VAL A 1 418  ? 140.018 129.660 182.929 1.00 82.04  ? 763  VAL A N     1 
ATOM   451  C  CA    . VAL A 1 418  ? 138.755 128.966 183.108 1.00 82.56  ? 763  VAL A CA    1 
ATOM   452  C  C     . VAL A 1 418  ? 137.936 129.108 181.829 1.00 84.66  ? 763  VAL A C     1 
ATOM   453  O  O     . VAL A 1 418  ? 138.353 129.753 180.868 1.00 88.59  ? 763  VAL A O     1 
ATOM   454  C  CB    . VAL A 1 418  ? 137.968 129.494 184.323 1.00 83.24  ? 763  VAL A CB    1 
ATOM   455  C  CG1   . VAL A 1 418  ? 138.871 129.590 185.536 1.00 85.24  ? 763  VAL A CG1   1 
ATOM   456  C  CG2   . VAL A 1 418  ? 137.367 130.847 184.004 1.00 85.79  ? 763  VAL A CG2   1 
ATOM   457  N  N     . SER A 1 419  ? 136.755 128.498 181.829 1.00 90.87  ? 764  SER A N     1 
ATOM   458  C  CA    . SER A 1 419  ? 135.869 128.502 180.675 1.00 90.78  ? 764  SER A CA    1 
ATOM   459  C  C     . SER A 1 419  ? 134.527 129.113 181.046 1.00 93.19  ? 764  SER A C     1 
ATOM   460  O  O     . SER A 1 419  ? 134.046 128.946 182.170 1.00 94.82  ? 764  SER A O     1 
ATOM   461  C  CB    . SER A 1 419  ? 135.663 127.087 180.133 1.00 93.36  ? 764  SER A CB    1 
ATOM   462  O  OG    . SER A 1 419  ? 136.897 126.500 179.765 1.00 95.48  ? 764  SER A OG    1 
ATOM   463  N  N     . VAL A 1 420  ? 133.930 129.821 180.092 1.00 105.00 ? 765  VAL A N     1 
ATOM   464  C  CA    . VAL A 1 420  ? 132.615 130.433 180.242 1.00 106.45 ? 765  VAL A CA    1 
ATOM   465  C  C     . VAL A 1 420  ? 131.724 129.917 179.121 1.00 106.67 ? 765  VAL A C     1 
ATOM   466  O  O     . VAL A 1 420  ? 132.111 129.953 177.947 1.00 105.56 ? 765  VAL A O     1 
ATOM   467  C  CB    . VAL A 1 420  ? 132.695 131.970 180.217 1.00 99.71  ? 765  VAL A CB    1 
ATOM   468  C  CG1   . VAL A 1 420  ? 131.321 132.570 180.430 1.00 101.74 ? 765  VAL A CG1   1 
ATOM   469  C  CG2   . VAL A 1 420  ? 133.663 132.467 181.276 1.00 99.08  ? 765  VAL A CG2   1 
ATOM   470  N  N     . ILE A 1 421  ? 130.539 129.440 179.484 1.00 123.01 ? 766  ILE A N     1 
ATOM   471  C  CA    . ILE A 1 421  ? 129.618 128.816 178.540 1.00 123.67 ? 766  ILE A CA    1 
ATOM   472  C  C     . ILE A 1 421  ? 128.726 129.907 177.952 1.00 124.18 ? 766  ILE A C     1 
ATOM   473  O  O     . ILE A 1 421  ? 127.978 130.549 178.706 1.00 123.05 ? 766  ILE A O     1 
ATOM   474  C  CB    . ILE A 1 421  ? 128.786 127.719 179.218 1.00 124.11 ? 766  ILE A CB    1 
ATOM   475  C  CG1   . ILE A 1 421  ? 127.649 127.229 178.312 1.00 125.32 ? 766  ILE A CG1   1 
ATOM   476  C  CG2   . ILE A 1 421  ? 128.275 128.175 180.586 1.00 122.73 ? 766  ILE A CG2   1 
ATOM   477  C  CD1   . ILE A 1 421  ? 128.096 126.760 176.942 1.00 123.61 ? 766  ILE A CD1   1 
ATOM   478  N  N     . PRO A 1 422  ? 128.781 130.159 176.648 1.00 130.73 ? 767  PRO A N     1 
ATOM   479  C  CA    . PRO A 1 422  ? 127.890 131.155 176.050 1.00 130.82 ? 767  PRO A CA    1 
ATOM   480  C  C     . PRO A 1 422  ? 126.487 130.611 175.836 1.00 131.72 ? 767  PRO A C     1 
ATOM   481  O  O     . PRO A 1 422  ? 126.278 129.412 175.636 1.00 130.94 ? 767  PRO A O     1 
ATOM   482  C  CB    . PRO A 1 422  ? 128.567 131.471 174.712 1.00 128.73 ? 767  PRO A CB    1 
ATOM   483  C  CG    . PRO A 1 422  ? 129.274 130.211 174.362 1.00 128.44 ? 767  PRO A CG    1 
ATOM   484  C  CD    . PRO A 1 422  ? 129.736 129.614 175.667 1.00 128.85 ? 767  PRO A CD    1 
ATOM   485  N  N     . ASP A 1 423  ? 125.515 131.524 175.885 1.00 138.74 ? 768  ASP A N     1 
ATOM   486  C  CA    . ASP A 1 423  ? 124.129 131.138 175.643 1.00 138.92 ? 768  ASP A CA    1 
ATOM   487  C  C     . ASP A 1 423  ? 123.915 130.715 174.194 1.00 139.89 ? 768  ASP A C     1 
ATOM   488  O  O     . ASP A 1 423  ? 123.271 129.693 173.929 1.00 139.25 ? 768  ASP A O     1 
ATOM   489  C  CB    . ASP A 1 423  ? 123.193 132.291 176.008 1.00 137.45 ? 768  ASP A CB    1 
ATOM   490  C  CG    . ASP A 1 423  ? 121.778 131.828 176.286 1.00 138.24 ? 768  ASP A CG    1 
ATOM   491  O  OD1   . ASP A 1 423  ? 121.488 130.633 176.068 1.00 139.47 ? 768  ASP A OD1   1 
ATOM   492  O  OD2   . ASP A 1 423  ? 120.955 132.658 176.725 1.00 137.81 ? 768  ASP A OD2   1 
ATOM   493  N  N     . ASP A 1 424  ? 124.448 131.483 173.248 1.00 145.77 ? 769  ASP A N     1 
ATOM   494  C  CA    . ASP A 1 424  ? 124.287 131.159 171.839 1.00 146.11 ? 769  ASP A CA    1 
ATOM   495  C  C     . ASP A 1 424  ? 125.140 129.954 171.460 1.00 145.55 ? 769  ASP A C     1 
ATOM   496  O  O     . ASP A 1 424  ? 126.212 129.718 172.026 1.00 144.23 ? 769  ASP A O     1 
ATOM   497  C  CB    . ASP A 1 424  ? 124.660 132.359 170.970 1.00 146.57 ? 769  ASP A CB    1 
ATOM   498  C  CG    . ASP A 1 424  ? 126.029 132.914 171.304 1.00 146.98 ? 769  ASP A CG    1 
ATOM   499  O  OD1   . ASP A 1 424  ? 126.193 133.471 172.410 1.00 146.23 ? 769  ASP A OD1   1 
ATOM   500  O  OD2   . ASP A 1 424  ? 126.943 132.793 170.461 1.00 146.40 ? 769  ASP A OD2   1 
ATOM   501  N  N     . SER A 1 425  ? 124.653 129.187 170.489 1.00 147.24 ? 770  SER A N     1 
ATOM   502  C  CA    . SER A 1 425  ? 125.334 127.983 170.036 1.00 148.58 ? 770  SER A CA    1 
ATOM   503  C  C     . SER A 1 425  ? 126.275 128.232 168.864 1.00 149.28 ? 770  SER A C     1 
ATOM   504  O  O     . SER A 1 425  ? 126.898 127.281 168.380 1.00 149.02 ? 770  SER A O     1 
ATOM   505  C  CB    . SER A 1 425  ? 124.310 126.911 169.650 1.00 147.96 ? 770  SER A CB    1 
ATOM   506  O  OG    . SER A 1 425  ? 124.942 125.662 169.427 1.00 148.43 ? 770  SER A OG    1 
ATOM   507  N  N     . SER A 1 426  ? 126.387 129.476 168.392 1.00 145.11 ? 771  SER A N     1 
ATOM   508  C  CA    . SER A 1 426  ? 127.320 129.770 167.308 1.00 144.35 ? 771  SER A CA    1 
ATOM   509  C  C     . SER A 1 426  ? 128.758 129.509 167.736 1.00 144.71 ? 771  SER A C     1 
ATOM   510  O  O     . SER A 1 426  ? 129.547 128.935 166.976 1.00 143.18 ? 771  SER A O     1 
ATOM   511  C  CB    . SER A 1 426  ? 127.149 131.216 166.846 1.00 142.73 ? 771  SER A CB    1 
ATOM   512  O  OG    . SER A 1 426  ? 125.785 131.517 166.611 1.00 142.57 ? 771  SER A OG    1 
ATOM   513  N  N     . LYS A 1 427  ? 129.117 129.926 168.949 1.00 141.16 ? 772  LYS A N     1 
ATOM   514  C  CA    . LYS A 1 427  ? 130.431 129.648 169.506 1.00 140.88 ? 772  LYS A CA    1 
ATOM   515  C  C     . LYS A 1 427  ? 130.313 128.524 170.520 1.00 139.00 ? 772  LYS A C     1 
ATOM   516  O  O     . LYS A 1 427  ? 129.502 128.633 171.453 1.00 136.90 ? 772  LYS A O     1 
ATOM   517  C  CB    . LYS A 1 427  ? 131.015 130.894 170.161 1.00 138.82 ? 772  LYS A CB    1 
ATOM   518  C  CG    . LYS A 1 427  ? 131.802 131.781 169.209 1.00 137.10 ? 772  LYS A CG    1 
ATOM   519  C  CD    . LYS A 1 427  ? 130.889 132.704 168.418 1.00 138.42 ? 772  LYS A CD    1 
ATOM   520  C  CE    . LYS A 1 427  ? 129.935 133.458 169.327 1.00 137.13 ? 772  LYS A CE    1 
ATOM   521  N  NZ    . LYS A 1 427  ? 128.953 134.264 168.551 1.00 137.42 ? 772  LYS A NZ    1 
ATOM   522  N  N     . PRO A 1 428  ? 131.064 127.427 170.369 1.00 134.30 ? 773  PRO A N     1 
ATOM   523  C  CA    . PRO A 1 428  ? 130.945 126.305 171.312 1.00 133.90 ? 773  PRO A CA    1 
ATOM   524  C  C     . PRO A 1 428  ? 131.145 126.715 172.763 1.00 135.14 ? 773  PRO A C     1 
ATOM   525  O  O     . PRO A 1 428  ? 130.261 126.501 173.598 1.00 136.96 ? 773  PRO A O     1 
ATOM   526  C  CB    . PRO A 1 428  ? 132.044 125.335 170.858 1.00 133.38 ? 773  PRO A CB    1 
ATOM   527  C  CG    . PRO A 1 428  ? 132.377 125.714 169.462 1.00 134.29 ? 773  PRO A CG    1 
ATOM   528  C  CD    . PRO A 1 428  ? 131.896 127.107 169.196 1.00 134.41 ? 773  PRO A CD    1 
ATOM   529  N  N     . LEU A 1 429  ? 132.296 127.306 173.076 1.00 120.04 ? 774  LEU A N     1 
ATOM   530  C  CA    . LEU A 1 429  ? 132.582 127.719 174.443 1.00 118.09 ? 774  LEU A CA    1 
ATOM   531  C  C     . LEU A 1 429  ? 133.630 128.821 174.419 1.00 118.55 ? 774  LEU A C     1 
ATOM   532  O  O     . LEU A 1 429  ? 134.426 128.927 173.483 1.00 119.20 ? 774  LEU A O     1 
ATOM   533  C  CB    . LEU A 1 429  ? 133.055 126.540 175.303 1.00 116.25 ? 774  LEU A CB    1 
ATOM   534  C  CG    . LEU A 1 429  ? 134.517 126.100 175.195 1.00 118.35 ? 774  LEU A CG    1 
ATOM   535  C  CD1   . LEU A 1 429  ? 134.868 125.166 176.340 1.00 117.76 ? 774  LEU A CD1   1 
ATOM   536  C  CD2   . LEU A 1 429  ? 134.806 125.434 173.859 1.00 118.32 ? 774  LEU A CD2   1 
ATOM   537  N  N     . TYR A 1 430  ? 133.616 129.638 175.467 1.00 102.27 ? 775  TYR A N     1 
ATOM   538  C  CA    . TYR A 1 430  ? 134.561 130.732 175.629 1.00 97.05  ? 775  TYR A CA    1 
ATOM   539  C  C     . TYR A 1 430  ? 135.628 130.351 176.644 1.00 95.66  ? 775  TYR A C     1 
ATOM   540  O  O     . TYR A 1 430  ? 135.359 129.642 177.614 1.00 97.90  ? 775  TYR A O     1 
ATOM   541  C  CB    . TYR A 1 430  ? 133.850 132.004 176.091 1.00 97.95  ? 775  TYR A CB    1 
ATOM   542  C  CG    . TYR A 1 430  ? 133.261 132.834 174.977 1.00 101.67 ? 775  TYR A CG    1 
ATOM   543  C  CD1   . TYR A 1 430  ? 134.078 133.533 174.100 1.00 101.98 ? 775  TYR A CD1   1 
ATOM   544  C  CD2   . TYR A 1 430  ? 131.887 132.929 174.810 1.00 102.20 ? 775  TYR A CD2   1 
ATOM   545  C  CE1   . TYR A 1 430  ? 133.542 134.297 173.083 1.00 103.54 ? 775  TYR A CE1   1 
ATOM   546  C  CE2   . TYR A 1 430  ? 131.343 133.689 173.797 1.00 102.34 ? 775  TYR A CE2   1 
ATOM   547  C  CZ    . TYR A 1 430  ? 132.175 134.371 172.937 1.00 102.90 ? 775  TYR A CZ    1 
ATOM   548  O  OH    . TYR A 1 430  ? 131.635 135.131 171.925 1.00 102.83 ? 775  TYR A OH    1 
ATOM   549  N  N     . LEU A 1 431  ? 136.843 130.841 176.423 1.00 71.47  ? 776  LEU A N     1 
ATOM   550  C  CA    . LEU A 1 431  ? 137.959 130.607 177.328 1.00 73.46  ? 776  LEU A CA    1 
ATOM   551  C  C     . LEU A 1 431  ? 138.483 131.943 177.825 1.00 75.94  ? 776  LEU A C     1 
ATOM   552  O  O     . LEU A 1 431  ? 138.802 132.823 177.021 1.00 83.20  ? 776  LEU A O     1 
ATOM   553  C  CB    . LEU A 1 431  ? 139.072 129.823 176.634 1.00 74.06  ? 776  LEU A CB    1 
ATOM   554  C  CG    . LEU A 1 431  ? 138.865 128.312 176.575 1.00 76.90  ? 776  LEU A CG    1 
ATOM   555  C  CD1   . LEU A 1 431  ? 139.401 127.756 175.271 1.00 77.91  ? 776  LEU A CD1   1 
ATOM   556  C  CD2   . LEU A 1 431  ? 139.535 127.646 177.760 1.00 77.68  ? 776  LEU A CD2   1 
ATOM   557  N  N     . ALA A 1 432  ? 138.575 132.093 179.143 1.00 68.56  ? 777  ALA A N     1 
ATOM   558  C  CA    . ALA A 1 432  ? 139.016 133.332 179.758 1.00 63.47  ? 777  ALA A CA    1 
ATOM   559  C  C     . ALA A 1 432  ? 140.122 133.029 180.754 1.00 70.68  ? 777  ALA A C     1 
ATOM   560  O  O     . ALA A 1 432  ? 140.337 131.883 181.146 1.00 81.77  ? 777  ALA A O     1 
ATOM   561  C  CB    . ALA A 1 432  ? 137.859 134.054 180.455 1.00 66.13  ? 777  ALA A CB    1 
ATOM   562  N  N     . ARG A 1 433  ? 140.833 134.076 181.158 1.00 78.92  ? 778  ARG A N     1 
ATOM   563  C  CA    . ARG A 1 433  ? 141.886 133.987 182.156 1.00 80.98  ? 778  ARG A CA    1 
ATOM   564  C  C     . ARG A 1 433  ? 141.487 134.831 183.354 1.00 84.16  ? 778  ARG A C     1 
ATOM   565  O  O     . ARG A 1 433  ? 141.123 136.000 183.197 1.00 92.73  ? 778  ARG A O     1 
ATOM   566  C  CB    . ARG A 1 433  ? 143.222 134.465 181.587 1.00 79.75  ? 778  ARG A CB    1 
ATOM   567  C  CG    . ARG A 1 433  ? 144.317 134.623 182.620 1.00 79.61  ? 778  ARG A CG    1 
ATOM   568  C  CD    . ARG A 1 433  ? 145.577 135.190 181.992 1.00 81.02  ? 778  ARG A CD    1 
ATOM   569  N  NE    . ARG A 1 433  ? 146.344 134.167 181.291 1.00 82.84  ? 778  ARG A NE    1 
ATOM   570  C  CZ    . ARG A 1 433  ? 147.150 133.300 181.886 1.00 87.01  ? 778  ARG A CZ    1 
ATOM   571  N  NH1   . ARG A 1 433  ? 147.325 133.306 183.197 1.00 88.35  ? 778  ARG A NH1   1 
ATOM   572  N  NH2   . ARG A 1 433  ? 147.798 132.403 181.148 1.00 86.85  ? 778  ARG A NH2   1 
ATOM   573  N  N     . VAL A 1 434  ? 141.544 134.240 184.540 1.00 90.21  ? 779  VAL A N     1 
ATOM   574  C  CA    . VAL A 1 434  ? 141.172 134.945 185.759 1.00 89.75  ? 779  VAL A CA    1 
ATOM   575  C  C     . VAL A 1 434  ? 142.341 135.814 186.198 1.00 94.30  ? 779  VAL A C     1 
ATOM   576  O  O     . VAL A 1 434  ? 143.469 135.328 186.341 1.00 98.37  ? 779  VAL A O     1 
ATOM   577  C  CB    . VAL A 1 434  ? 140.777 133.951 186.860 1.00 88.79  ? 779  VAL A CB    1 
ATOM   578  C  CG1   . VAL A 1 434  ? 140.395 134.692 188.126 1.00 92.06  ? 779  VAL A CG1   1 
ATOM   579  C  CG2   . VAL A 1 434  ? 139.645 133.066 186.384 1.00 88.64  ? 779  VAL A CG2   1 
ATOM   580  N  N     . THR A 1 435  ? 142.080 137.104 186.411 1.00 100.00 ? 780  THR A N     1 
ATOM   581  C  CA    . THR A 1 435  ? 143.125 138.021 186.847 1.00 99.54  ? 780  THR A CA    1 
ATOM   582  C  C     . THR A 1 435  ? 143.004 138.445 188.301 1.00 101.88 ? 780  THR A C     1 
ATOM   583  O  O     . THR A 1 435  ? 144.019 138.773 188.917 1.00 103.44 ? 780  THR A O     1 
ATOM   584  C  CB    . THR A 1 435  ? 143.138 139.275 185.968 1.00 99.54  ? 780  THR A CB    1 
ATOM   585  O  OG1   . THR A 1 435  ? 141.794 139.628 185.622 1.00 104.39 ? 780  THR A OG1   1 
ATOM   586  C  CG2   . THR A 1 435  ? 143.934 139.025 184.700 1.00 100.04 ? 780  THR A CG2   1 
ATOM   587  N  N     . ALA A 1 436  ? 141.797 138.451 188.861 1.00 111.13 ? 781  ALA A N     1 
ATOM   588  C  CA    . ALA A 1 436  ? 141.608 138.796 190.262 1.00 113.70 ? 781  ALA A CA    1 
ATOM   589  C  C     . ALA A 1 436  ? 140.280 138.227 190.732 1.00 115.53 ? 781  ALA A C     1 
ATOM   590  O  O     . ALA A 1 436  ? 139.400 137.913 189.927 1.00 115.77 ? 781  ALA A O     1 
ATOM   591  C  CB    . ALA A 1 436  ? 141.653 140.310 190.484 1.00 114.03 ? 781  ALA A CB    1 
ATOM   592  N  N     . LEU A 1 437  ? 140.144 138.110 192.053 1.00 123.16 ? 782  LEU A N     1 
ATOM   593  C  CA    . LEU A 1 437  ? 138.956 137.519 192.674 1.00 122.84 ? 782  LEU A CA    1 
ATOM   594  C  C     . LEU A 1 437  ? 138.582 138.369 193.887 1.00 123.90 ? 782  LEU A C     1 
ATOM   595  O  O     . LEU A 1 437  ? 139.127 138.184 194.978 1.00 124.14 ? 782  LEU A O     1 
ATOM   596  C  CB    . LEU A 1 437  ? 139.210 136.068 193.060 1.00 125.00 ? 782  LEU A CB    1 
ATOM   597  C  CG    . LEU A 1 437  ? 138.828 135.014 192.021 1.00 124.12 ? 782  LEU A CG    1 
ATOM   598  C  CD1   . LEU A 1 437  ? 139.691 133.774 192.175 1.00 122.73 ? 782  LEU A CD1   1 
ATOM   599  C  CD2   . LEU A 1 437  ? 137.358 134.660 192.138 1.00 122.45 ? 782  LEU A CD2   1 
ATOM   600  N  N     . TRP A 1 438  ? 137.652 139.298 193.690 1.00 130.76 ? 783  TRP A N     1 
ATOM   601  C  CA    . TRP A 1 438  ? 137.147 140.140 194.764 1.00 132.24 ? 783  TRP A CA    1 
ATOM   602  C  C     . TRP A 1 438  ? 135.679 139.828 195.028 1.00 131.65 ? 783  TRP A C     1 
ATOM   603  O  O     . TRP A 1 438  ? 135.006 139.158 194.240 1.00 131.19 ? 783  TRP A O     1 
ATOM   604  C  CB    . TRP A 1 438  ? 137.339 141.628 194.437 1.00 130.54 ? 783  TRP A CB    1 
ATOM   605  C  CG    . TRP A 1 438  ? 136.410 142.172 193.389 1.00 129.75 ? 783  TRP A CG    1 
ATOM   606  C  CD1   . TRP A 1 438  ? 135.099 142.521 193.551 1.00 128.82 ? 783  TRP A CD1   1 
ATOM   607  C  CD2   . TRP A 1 438  ? 136.730 142.448 192.021 1.00 130.15 ? 783  TRP A CD2   1 
ATOM   608  N  NE1   . TRP A 1 438  ? 134.583 142.987 192.368 1.00 127.15 ? 783  TRP A NE1   1 
ATOM   609  C  CE2   . TRP A 1 438  ? 135.564 142.952 191.413 1.00 129.30 ? 783  TRP A CE2   1 
ATOM   610  C  CE3   . TRP A 1 438  ? 137.888 142.314 191.251 1.00 129.52 ? 783  TRP A CE3   1 
ATOM   611  C  CZ2   . TRP A 1 438  ? 135.522 143.321 190.073 1.00 128.73 ? 783  TRP A CZ2   1 
ATOM   612  C  CZ3   . TRP A 1 438  ? 137.845 142.682 189.919 1.00 128.55 ? 783  TRP A CZ3   1 
ATOM   613  C  CH2   . TRP A 1 438  ? 136.670 143.179 189.344 1.00 128.43 ? 783  TRP A CH2   1 
ATOM   614  N  N     . GLU A 1 439  ? 135.184 140.327 196.157 1.00 135.12 ? 784  GLU A N     1 
ATOM   615  C  CA    . GLU A 1 439  ? 133.814 140.091 196.590 1.00 134.83 ? 784  GLU A CA    1 
ATOM   616  C  C     . GLU A 1 439  ? 133.048 141.405 196.598 1.00 135.17 ? 784  GLU A C     1 
ATOM   617  O  O     . GLU A 1 439  ? 133.527 142.405 197.141 1.00 134.36 ? 784  GLU A O     1 
ATOM   618  C  CB    . GLU A 1 439  ? 133.777 139.452 197.980 1.00 135.33 ? 784  GLU A CB    1 
ATOM   619  C  CG    . GLU A 1 439  ? 132.664 138.434 198.160 1.00 134.96 ? 784  GLU A CG    1 
ATOM   620  C  CD    . GLU A 1 439  ? 131.289 139.069 198.156 1.00 136.14 ? 784  GLU A CD    1 
ATOM   621  O  OE1   . GLU A 1 439  ? 131.143 140.176 198.714 1.00 136.60 ? 784  GLU A OE1   1 
ATOM   622  O  OE2   . GLU A 1 439  ? 130.353 138.462 197.594 1.00 136.69 ? 784  GLU A OE2   1 
ATOM   623  N  N     . ASP A 1 440  ? 131.860 141.395 196.000 1.00 137.70 ? 785  ASP A N     1 
ATOM   624  C  CA    . ASP A 1 440  ? 130.973 142.548 195.978 1.00 138.37 ? 785  ASP A CA    1 
ATOM   625  C  C     . ASP A 1 440  ? 129.720 142.240 196.786 1.00 138.89 ? 785  ASP A C     1 
ATOM   626  O  O     . ASP A 1 440  ? 129.192 141.125 196.729 1.00 137.90 ? 785  ASP A O     1 
ATOM   627  C  CB    . ASP A 1 440  ? 130.592 142.927 194.545 1.00 138.90 ? 785  ASP A CB    1 
ATOM   628  C  CG    . ASP A 1 440  ? 129.942 144.294 194.459 1.00 139.15 ? 785  ASP A CG    1 
ATOM   629  O  OD1   . ASP A 1 440  ? 128.710 144.381 194.648 1.00 138.89 ? 785  ASP A OD1   1 
ATOM   630  O  OD2   . ASP A 1 440  ? 130.662 145.281 194.202 1.00 138.98 ? 785  ASP A OD2   1 
ATOM   631  N  N     . SER A 1 441  ? 129.251 143.232 197.543 1.00 141.43 ? 786  SER A N     1 
ATOM   632  C  CA    . SER A 1 441  ? 128.086 143.027 198.398 1.00 140.42 ? 786  SER A CA    1 
ATOM   633  C  C     . SER A 1 441  ? 126.825 142.814 197.569 1.00 140.35 ? 786  SER A C     1 
ATOM   634  O  O     . SER A 1 441  ? 126.184 141.760 197.648 1.00 138.36 ? 786  SER A O     1 
ATOM   635  C  CB    . SER A 1 441  ? 127.919 144.218 199.344 1.00 139.24 ? 786  SER A CB    1 
ATOM   636  O  OG    . SER A 1 441  ? 127.926 145.440 198.628 1.00 139.20 ? 786  SER A OG    1 
ATOM   637  N  N     . SER A 1 442  ? 126.454 143.809 196.761 1.00 145.02 ? 787  SER A N     1 
ATOM   638  C  CA    . SER A 1 442  ? 125.224 143.708 195.982 1.00 144.27 ? 787  SER A CA    1 
ATOM   639  C  C     . SER A 1 442  ? 125.383 142.750 194.807 1.00 144.88 ? 787  SER A C     1 
ATOM   640  O  O     . SER A 1 442  ? 124.483 141.949 194.527 1.00 144.35 ? 787  SER A O     1 
ATOM   641  C  CB    . SER A 1 442  ? 124.800 145.092 195.492 1.00 144.33 ? 787  SER A CB    1 
ATOM   642  O  OG    . SER A 1 442  ? 125.825 145.696 194.724 1.00 143.39 ? 787  SER A OG    1 
ATOM   643  N  N     . ASN A 1 443  ? 126.516 142.819 194.106 1.00 143.45 ? 788  ASN A N     1 
ATOM   644  C  CA    . ASN A 1 443  ? 126.711 141.988 192.922 1.00 141.82 ? 788  ASN A CA    1 
ATOM   645  C  C     . ASN A 1 443  ? 126.982 140.531 193.273 1.00 141.99 ? 788  ASN A C     1 
ATOM   646  O  O     . ASN A 1 443  ? 126.480 139.632 192.589 1.00 142.97 ? 788  ASN A O     1 
ATOM   647  C  CB    . ASN A 1 443  ? 127.859 142.542 192.076 1.00 141.35 ? 788  ASN A CB    1 
ATOM   648  C  CG    . ASN A 1 443  ? 127.682 144.010 191.746 1.00 142.35 ? 788  ASN A CG    1 
ATOM   649  O  OD1   . ASN A 1 443  ? 126.579 144.549 191.834 1.00 143.38 ? 788  ASN A OD1   1 
ATOM   650  N  ND2   . ASN A 1 443  ? 128.772 144.667 191.366 1.00 141.86 ? 788  ASN A ND2   1 
ATOM   651  N  N     . GLY A 1 444  ? 127.761 140.275 194.320 1.00 135.57 ? 789  GLY A N     1 
ATOM   652  C  CA    . GLY A 1 444  ? 128.118 138.917 194.679 1.00 135.16 ? 789  GLY A CA    1 
ATOM   653  C  C     . GLY A 1 444  ? 129.606 138.659 194.559 1.00 136.89 ? 789  GLY A C     1 
ATOM   654  O  O     . GLY A 1 444  ? 130.415 139.576 194.727 1.00 137.29 ? 789  GLY A O     1 
ATOM   655  N  N     . GLN A 1 445  ? 129.982 137.417 194.268 1.00 132.99 ? 790  GLN A N     1 
ATOM   656  C  CA    . GLN A 1 445  ? 131.388 137.055 194.125 1.00 132.39 ? 790  GLN A CA    1 
ATOM   657  C  C     . GLN A 1 445  ? 131.827 137.343 192.694 1.00 133.15 ? 790  GLN A C     1 
ATOM   658  O  O     . GLN A 1 445  ? 131.411 136.654 191.757 1.00 131.46 ? 790  GLN A O     1 
ATOM   659  C  CB    . GLN A 1 445  ? 131.598 135.588 194.487 1.00 131.29 ? 790  GLN A CB    1 
ATOM   660  C  CG    . GLN A 1 445  ? 131.722 135.339 195.980 1.00 130.25 ? 790  GLN A CG    1 
ATOM   661  C  CD    . GLN A 1 445  ? 132.840 134.377 196.317 1.00 131.71 ? 790  GLN A CD    1 
ATOM   662  O  OE1   . GLN A 1 445  ? 134.002 134.625 196.000 1.00 131.49 ? 790  GLN A OE1   1 
ATOM   663  N  NE2   . GLN A 1 445  ? 132.494 133.272 196.965 1.00 132.27 ? 790  GLN A NE2   1 
ATOM   664  N  N     . MET A 1 446  ? 132.668 138.357 192.526 1.00 127.61 ? 791  MET A N     1 
ATOM   665  C  CA    . MET A 1 446  ? 133.111 138.815 191.219 1.00 126.20 ? 791  MET A CA    1 
ATOM   666  C  C     . MET A 1 446  ? 134.502 138.279 190.894 1.00 124.82 ? 791  MET A C     1 
ATOM   667  O  O     . MET A 1 446  ? 135.258 137.859 191.773 1.00 124.04 ? 791  MET A O     1 
ATOM   668  C  CB    . MET A 1 446  ? 133.135 140.347 191.162 1.00 125.43 ? 791  MET A CB    1 
ATOM   669  C  CG    . MET A 1 446  ? 131.818 141.107 190.888 1.00 123.92 ? 791  MET A CG    1 
ATOM   670  S  SD    . MET A 1 446  ? 130.582 140.496 189.710 1.00 124.94 ? 791  MET A SD    1 
ATOM   671  C  CE    . MET A 1 446  ? 129.799 139.141 190.581 1.00 124.29 ? 791  MET A CE    1 
ATOM   672  N  N     . PHE A 1 447  ? 134.827 138.296 189.603 1.00 107.56 ? 792  PHE A N     1 
ATOM   673  C  CA    . PHE A 1 447  ? 136.193 138.067 189.154 1.00 106.46 ? 792  PHE A CA    1 
ATOM   674  C  C     . PHE A 1 447  ? 136.386 138.720 187.793 1.00 106.62 ? 792  PHE A C     1 
ATOM   675  O  O     . PHE A 1 447  ? 135.437 138.847 187.016 1.00 108.99 ? 792  PHE A O     1 
ATOM   676  C  CB    . PHE A 1 447  ? 136.551 136.573 189.108 1.00 108.96 ? 792  PHE A CB    1 
ATOM   677  C  CG    . PHE A 1 447  ? 136.006 135.827 187.913 1.00 109.74 ? 792  PHE A CG    1 
ATOM   678  C  CD1   . PHE A 1 447  ? 134.697 135.986 187.495 1.00 109.75 ? 792  PHE A CD1   1 
ATOM   679  C  CD2   . PHE A 1 447  ? 136.821 134.965 187.203 1.00 107.90 ? 792  PHE A CD2   1 
ATOM   680  C  CE1   . PHE A 1 447  ? 134.216 135.289 186.402 1.00 107.38 ? 792  PHE A CE1   1 
ATOM   681  C  CE2   . PHE A 1 447  ? 136.344 134.274 186.107 1.00 105.49 ? 792  PHE A CE2   1 
ATOM   682  C  CZ    . PHE A 1 447  ? 135.042 134.438 185.707 1.00 103.87 ? 792  PHE A CZ    1 
ATOM   683  N  N     . HIS A 1 448  ? 137.616 139.148 187.522 1.00 94.77  ? 793  HIS A N     1 
ATOM   684  C  CA    . HIS A 1 448  ? 137.949 139.808 186.267 1.00 95.40  ? 793  HIS A CA    1 
ATOM   685  C  C     . HIS A 1 448  ? 138.454 138.765 185.280 1.00 96.30  ? 793  HIS A C     1 
ATOM   686  O  O     . HIS A 1 448  ? 139.433 138.061 185.557 1.00 97.60  ? 793  HIS A O     1 
ATOM   687  C  CB    . HIS A 1 448  ? 138.995 140.899 186.492 1.00 97.99  ? 793  HIS A CB    1 
ATOM   688  C  CG    . HIS A 1 448  ? 139.203 141.795 185.311 1.00 95.74  ? 793  HIS A CG    1 
ATOM   689  N  ND1   . HIS A 1 448  ? 138.162 142.405 184.646 1.00 93.83  ? 793  HIS A ND1   1 
ATOM   690  C  CD2   . HIS A 1 448  ? 140.334 142.194 184.684 1.00 94.55  ? 793  HIS A CD2   1 
ATOM   691  C  CE1   . HIS A 1 448  ? 138.642 143.136 183.656 1.00 95.08  ? 793  HIS A CE1   1 
ATOM   692  N  NE2   . HIS A 1 448  ? 139.958 143.026 183.658 1.00 94.56  ? 793  HIS A NE2   1 
ATOM   693  N  N     . ALA A 1 449  ? 137.781 138.657 184.138 1.00 86.28  ? 794  ALA A N     1 
ATOM   694  C  CA    . ALA A 1 449  ? 138.107 137.674 183.118 1.00 80.96  ? 794  ALA A CA    1 
ATOM   695  C  C     . ALA A 1 449  ? 138.673 138.394 181.905 1.00 82.07  ? 794  ALA A C     1 
ATOM   696  O  O     . ALA A 1 449  ? 138.019 139.280 181.342 1.00 91.15  ? 794  ALA A O     1 
ATOM   697  C  CB    . ALA A 1 449  ? 136.873 136.860 182.732 1.00 82.18  ? 794  ALA A CB    1 
ATOM   698  N  N     . HIS A 1 450  ? 139.885 138.014 181.514 1.00 67.74  ? 795  HIS A N     1 
ATOM   699  C  CA    . HIS A 1 450  ? 140.528 138.500 180.302 1.00 71.80  ? 795  HIS A CA    1 
ATOM   700  C  C     . HIS A 1 450  ? 140.357 137.438 179.223 1.00 71.01  ? 795  HIS A C     1 
ATOM   701  O  O     . HIS A 1 450  ? 140.844 136.315 179.376 1.00 71.61  ? 795  HIS A O     1 
ATOM   702  C  CB    . HIS A 1 450  ? 142.003 138.791 180.567 1.00 68.50  ? 795  HIS A CB    1 
ATOM   703  C  CG    . HIS A 1 450  ? 142.761 139.233 179.359 1.00 71.43  ? 795  HIS A CG    1 
ATOM   704  N  ND1   . HIS A 1 450  ? 143.521 138.369 178.602 1.00 73.37  ? 795  HIS A ND1   1 
ATOM   705  C  CD2   . HIS A 1 450  ? 142.888 140.450 178.782 1.00 72.62  ? 795  HIS A CD2   1 
ATOM   706  C  CE1   . HIS A 1 450  ? 144.080 139.034 177.608 1.00 74.73  ? 795  HIS A CE1   1 
ATOM   707  N  NE2   . HIS A 1 450  ? 143.711 140.299 177.693 1.00 74.62  ? 795  HIS A NE2   1 
ATOM   708  N  N     . TRP A 1 451  ? 139.659 137.781 178.148 1.00 68.19  ? 796  TRP A N     1 
ATOM   709  C  CA    . TRP A 1 451  ? 139.195 136.760 177.225 1.00 63.51  ? 796  TRP A CA    1 
ATOM   710  C  C     . TRP A 1 451  ? 140.317 136.264 176.318 1.00 58.36  ? 796  TRP A C     1 
ATOM   711  O  O     . TRP A 1 451  ? 141.355 136.908 176.148 1.00 52.12  ? 796  TRP A O     1 
ATOM   712  C  CB    . TRP A 1 451  ? 138.040 137.284 176.374 1.00 68.96  ? 796  TRP A CB    1 
ATOM   713  C  CG    . TRP A 1 451  ? 136.788 137.521 177.148 1.00 64.20  ? 796  TRP A CG    1 
ATOM   714  C  CD1   . TRP A 1 451  ? 136.246 138.725 177.474 1.00 68.88  ? 796  TRP A CD1   1 
ATOM   715  C  CD2   . TRP A 1 451  ? 135.917 136.528 177.696 1.00 62.74  ? 796  TRP A CD2   1 
ATOM   716  N  NE1   . TRP A 1 451  ? 135.091 138.546 178.191 1.00 73.08  ? 796  TRP A NE1   1 
ATOM   717  C  CE2   . TRP A 1 451  ? 134.867 137.204 178.340 1.00 69.23  ? 796  TRP A CE2   1 
ATOM   718  C  CE3   . TRP A 1 451  ? 135.922 135.133 177.702 1.00 70.00  ? 796  TRP A CE3   1 
ATOM   719  C  CZ2   . TRP A 1 451  ? 133.835 136.535 178.985 1.00 74.27  ? 796  TRP A CZ2   1 
ATOM   720  C  CZ3   . TRP A 1 451  ? 134.896 134.471 178.345 1.00 73.34  ? 796  TRP A CZ3   1 
ATOM   721  C  CH2   . TRP A 1 451  ? 133.867 135.171 178.976 1.00 72.58  ? 796  TRP A CH2   1 
ATOM   722  N  N     . PHE A 1 452  ? 140.083 135.092 175.736 1.00 56.12  ? 797  PHE A N     1 
ATOM   723  C  CA    . PHE A 1 452  ? 140.956 134.477 174.750 1.00 53.78  ? 797  PHE A CA    1 
ATOM   724  C  C     . PHE A 1 452  ? 140.210 134.368 173.429 1.00 56.48  ? 797  PHE A C     1 
ATOM   725  O  O     . PHE A 1 452  ? 138.993 134.161 173.405 1.00 62.27  ? 797  PHE A O     1 
ATOM   726  C  CB    . PHE A 1 452  ? 141.399 133.076 175.187 1.00 57.56  ? 797  PHE A CB    1 
ATOM   727  C  CG    . PHE A 1 452  ? 142.596 133.061 176.088 1.00 57.12  ? 797  PHE A CG    1 
ATOM   728  C  CD1   . PHE A 1 452  ? 143.779 133.662 175.705 1.00 59.07  ? 797  PHE A CD1   1 
ATOM   729  C  CD2   . PHE A 1 452  ? 142.543 132.423 177.310 1.00 54.58  ? 797  PHE A CD2   1 
ATOM   730  C  CE1   . PHE A 1 452  ? 144.878 133.636 176.533 1.00 57.59  ? 797  PHE A CE1   1 
ATOM   731  C  CE2   . PHE A 1 452  ? 143.639 132.396 178.138 1.00 55.45  ? 797  PHE A CE2   1 
ATOM   732  C  CZ    . PHE A 1 452  ? 144.807 133.003 177.749 1.00 55.71  ? 797  PHE A CZ    1 
ATOM   733  N  N     . CYS A 1 453  ? 140.940 134.501 172.328 1.00 56.04  ? 798  CYS A N     1 
ATOM   734  C  CA    . CYS A 1 453  ? 140.385 134.276 171.000 1.00 53.81  ? 798  CYS A CA    1 
ATOM   735  C  C     . CYS A 1 453  ? 140.861 132.923 170.492 1.00 59.09  ? 798  CYS A C     1 
ATOM   736  O  O     . CYS A 1 453  ? 142.067 132.662 170.448 1.00 64.24  ? 798  CYS A O     1 
ATOM   737  C  CB    . CYS A 1 453  ? 140.787 135.388 170.033 1.00 59.48  ? 798  CYS A CB    1 
ATOM   738  S  SG    . CYS A 1 453  ? 139.624 136.768 169.963 1.00 77.94  ? 798  CYS A SG    1 
ATOM   739  N  N     . ALA A 1 454  ? 139.916 132.068 170.117 1.00 64.05  ? 799  ALA A N     1 
ATOM   740  C  CA    . ALA A 1 454  ? 140.266 130.764 169.585 1.00 67.25  ? 799  ALA A CA    1 
ATOM   741  C  C     . ALA A 1 454  ? 140.913 130.907 168.211 1.00 68.98  ? 799  ALA A C     1 
ATOM   742  O  O     . ALA A 1 454  ? 140.783 131.930 167.535 1.00 68.82  ? 799  ALA A O     1 
ATOM   743  C  CB    . ALA A 1 454  ? 139.029 129.871 169.497 1.00 65.72  ? 799  ALA A CB    1 
ATOM   744  N  N     . GLY A 1 455  ? 141.626 129.858 167.801 1.00 64.19  ? 800  GLY A N     1 
ATOM   745  C  CA    . GLY A 1 455  ? 142.302 129.891 166.518 1.00 58.76  ? 800  GLY A CA    1 
ATOM   746  C  C     . GLY A 1 455  ? 141.369 129.876 165.328 1.00 64.39  ? 800  GLY A C     1 
ATOM   747  O  O     . GLY A 1 455  ? 141.773 130.278 164.233 1.00 67.18  ? 800  GLY A O     1 
ATOM   748  N  N     . THR A 1 456  ? 140.133 129.427 165.515 1.00 73.81  ? 801  THR A N     1 
ATOM   749  C  CA    . THR A 1 456  ? 139.172 129.319 164.427 1.00 74.09  ? 801  THR A CA    1 
ATOM   750  C  C     . THR A 1 456  ? 138.315 130.566 164.259 1.00 71.05  ? 801  THR A C     1 
ATOM   751  O  O     . THR A 1 456  ? 137.382 130.551 163.451 1.00 74.60  ? 801  THR A O     1 
ATOM   752  C  CB    . THR A 1 456  ? 138.268 128.102 164.639 1.00 74.95  ? 801  THR A CB    1 
ATOM   753  O  OG1   . THR A 1 456  ? 137.587 128.223 165.894 1.00 75.52  ? 801  THR A OG1   1 
ATOM   754  C  CG2   . THR A 1 456  ? 139.091 126.824 164.641 1.00 70.37  ? 801  THR A CG2   1 
ATOM   755  N  N     . ASP A 1 457  ? 138.597 131.637 165.002 1.00 64.62  ? 802  ASP A N     1 
ATOM   756  C  CA    . ASP A 1 457  ? 137.858 132.884 164.874 1.00 66.84  ? 802  ASP A CA    1 
ATOM   757  C  C     . ASP A 1 457  ? 138.701 134.039 164.354 1.00 65.02  ? 802  ASP A C     1 
ATOM   758  O  O     . ASP A 1 457  ? 138.138 135.076 163.992 1.00 70.32  ? 802  ASP A O     1 
ATOM   759  C  CB    . ASP A 1 457  ? 137.244 133.283 166.224 1.00 72.60  ? 802  ASP A CB    1 
ATOM   760  C  CG    . ASP A 1 457  ? 136.220 132.284 166.714 1.00 77.79  ? 802  ASP A CG    1 
ATOM   761  O  OD1   . ASP A 1 457  ? 135.674 131.533 165.879 1.00 79.16  ? 802  ASP A OD1   1 
ATOM   762  O  OD2   . ASP A 1 457  ? 135.959 132.248 167.934 1.00 78.01  ? 802  ASP A OD2   1 
ATOM   763  N  N     . THR A 1 458  ? 140.020 133.891 164.303 1.00 49.43  ? 803  THR A N     1 
ATOM   764  C  CA    . THR A 1 458  ? 140.896 134.953 163.833 1.00 51.63  ? 803  THR A CA    1 
ATOM   765  C  C     . THR A 1 458  ? 140.957 134.928 162.306 1.00 54.08  ? 803  THR A C     1 
ATOM   766  O  O     . THR A 1 458  ? 140.151 134.274 161.639 1.00 64.20  ? 803  THR A O     1 
ATOM   767  C  CB    . THR A 1 458  ? 142.279 134.812 164.459 1.00 48.36  ? 803  THR A CB    1 
ATOM   768  O  OG1   . THR A 1 458  ? 142.886 133.605 163.998 1.00 51.95  ? 803  THR A OG1   1 
ATOM   769  C  CG2   . THR A 1 458  ? 142.170 134.763 165.968 1.00 53.40  ? 803  THR A CG2   1 
ATOM   770  N  N     . VAL A 1 459  ? 141.914 135.664 161.733 1.00 43.56  ? 804  VAL A N     1 
ATOM   771  C  CA    . VAL A 1 459  ? 142.094 135.655 160.283 1.00 38.52  ? 804  VAL A CA    1 
ATOM   772  C  C     . VAL A 1 459  ? 142.488 134.268 159.798 1.00 49.79  ? 804  VAL A C     1 
ATOM   773  O  O     . VAL A 1 459  ? 142.196 133.896 158.655 1.00 48.56  ? 804  VAL A O     1 
ATOM   774  C  CB    . VAL A 1 459  ? 143.132 136.718 159.868 1.00 34.66  ? 804  VAL A CB    1 
ATOM   775  C  CG1   . VAL A 1 459  ? 144.458 136.463 160.551 1.00 43.00  ? 804  VAL A CG1   1 
ATOM   776  C  CG2   . VAL A 1 459  ? 143.306 136.741 158.361 1.00 36.46  ? 804  VAL A CG2   1 
ATOM   777  N  N     . LEU A 1 460  ? 143.132 133.473 160.657 1.00 48.14  ? 805  LEU A N     1 
ATOM   778  C  CA    . LEU A 1 460  ? 143.567 132.138 160.266 1.00 34.78  ? 805  LEU A CA    1 
ATOM   779  C  C     . LEU A 1 460  ? 142.406 131.241 159.867 1.00 36.02  ? 805  LEU A C     1 
ATOM   780  O  O     . LEU A 1 460  ? 142.618 130.259 159.150 1.00 47.15  ? 805  LEU A O     1 
ATOM   781  C  CB    . LEU A 1 460  ? 144.351 131.487 161.403 1.00 31.82  ? 805  LEU A CB    1 
ATOM   782  C  CG    . LEU A 1 460  ? 145.627 132.205 161.831 1.00 39.12  ? 805  LEU A CG    1 
ATOM   783  C  CD1   . LEU A 1 460  ? 146.349 131.411 162.903 1.00 41.21  ? 805  LEU A CD1   1 
ATOM   784  C  CD2   . LEU A 1 460  ? 146.524 132.428 160.634 1.00 39.78  ? 805  LEU A CD2   1 
ATOM   785  N  N     . GLY A 1 461  ? 141.191 131.553 160.307 1.00 45.76  ? 806  GLY A N     1 
ATOM   786  C  CA    . GLY A 1 461  ? 140.047 130.751 159.913 1.00 53.12  ? 806  GLY A CA    1 
ATOM   787  C  C     . GLY A 1 461  ? 140.166 129.330 160.420 1.00 60.44  ? 806  GLY A C     1 
ATOM   788  O  O     . GLY A 1 461  ? 140.682 129.074 161.513 1.00 62.23  ? 806  GLY A O     1 
ATOM   789  N  N     . ALA A 1 462  ? 139.686 128.385 159.613 1.00 61.16  ? 807  ALA A N     1 
ATOM   790  C  CA    . ALA A 1 462  ? 139.765 126.977 159.974 1.00 55.19  ? 807  ALA A CA    1 
ATOM   791  C  C     . ALA A 1 462  ? 141.177 126.418 159.872 1.00 52.08  ? 807  ALA A C     1 
ATOM   792  O  O     . ALA A 1 462  ? 141.406 125.286 160.309 1.00 55.46  ? 807  ALA A O     1 
ATOM   793  C  CB    . ALA A 1 462  ? 138.820 126.158 159.095 1.00 53.25  ? 807  ALA A CB    1 
ATOM   794  N  N     . THR A 1 463  ? 142.119 127.176 159.307 1.00 47.74  ? 808  THR A N     1 
ATOM   795  C  CA    . THR A 1 463  ? 143.477 126.670 159.135 1.00 49.98  ? 808  THR A CA    1 
ATOM   796  C  C     . THR A 1 463  ? 144.149 126.400 160.475 1.00 56.86  ? 808  THR A C     1 
ATOM   797  O  O     . THR A 1 463  ? 144.856 125.398 160.630 1.00 63.05  ? 808  THR A O     1 
ATOM   798  C  CB    . THR A 1 463  ? 144.307 127.655 158.316 1.00 42.62  ? 808  THR A CB    1 
ATOM   799  O  OG1   . THR A 1 463  ? 143.540 128.112 157.197 1.00 51.63  ? 808  THR A OG1   1 
ATOM   800  C  CG2   . THR A 1 463  ? 145.565 126.987 157.813 1.00 50.04  ? 808  THR A CG2   1 
ATOM   801  N  N     . SER A 1 464  ? 143.950 127.282 161.449 1.00 63.12  ? 809  SER A N     1 
ATOM   802  C  CA    . SER A 1 464  ? 144.611 127.131 162.737 1.00 58.10  ? 809  SER A CA    1 
ATOM   803  C  C     . SER A 1 464  ? 144.126 125.876 163.449 1.00 54.81  ? 809  SER A C     1 
ATOM   804  O  O     . SER A 1 464  ? 142.952 125.506 163.362 1.00 55.68  ? 809  SER A O     1 
ATOM   805  C  CB    . SER A 1 464  ? 144.360 128.356 163.611 1.00 59.44  ? 809  SER A CB    1 
ATOM   806  O  OG    . SER A 1 464  ? 145.393 128.515 164.566 1.00 60.57  ? 809  SER A OG    1 
ATOM   807  N  N     . ASP A 1 465  ? 145.044 125.214 164.148 1.00 62.42  ? 810  ASP A N     1 
ATOM   808  C  CA    . ASP A 1 465  ? 144.692 124.022 164.896 1.00 63.61  ? 810  ASP A CA    1 
ATOM   809  C  C     . ASP A 1 465  ? 143.756 124.386 166.045 1.00 65.20  ? 810  ASP A C     1 
ATOM   810  O  O     . ASP A 1 465  ? 143.833 125.488 166.592 1.00 70.42  ? 810  ASP A O     1 
ATOM   811  C  CB    . ASP A 1 465  ? 145.944 123.341 165.439 1.00 64.57  ? 810  ASP A CB    1 
ATOM   812  C  CG    . ASP A 1 465  ? 146.919 124.322 166.042 1.00 68.75  ? 810  ASP A CG    1 
ATOM   813  O  OD1   . ASP A 1 465  ? 146.738 125.539 165.832 1.00 70.44  ? 810  ASP A OD1   1 
ATOM   814  O  OD2   . ASP A 1 465  ? 147.867 123.879 166.724 1.00 67.67  ? 810  ASP A OD2   1 
ATOM   815  N  N     . PRO A 1 466  ? 142.859 123.474 166.432 1.00 71.19  ? 811  PRO A N     1 
ATOM   816  C  CA    . PRO A 1 466  ? 141.853 123.814 167.451 1.00 75.17  ? 811  PRO A CA    1 
ATOM   817  C  C     . PRO A 1 466  ? 142.429 124.099 168.829 1.00 70.97  ? 811  PRO A C     1 
ATOM   818  O  O     . PRO A 1 466  ? 141.689 124.588 169.693 1.00 71.47  ? 811  PRO A O     1 
ATOM   819  C  CB    . PRO A 1 466  ? 140.948 122.576 167.476 1.00 72.90  ? 811  PRO A CB    1 
ATOM   820  C  CG    . PRO A 1 466  ? 141.793 121.474 166.934 1.00 68.37  ? 811  PRO A CG    1 
ATOM   821  C  CD    . PRO A 1 466  ? 142.684 122.108 165.914 1.00 65.31  ? 811  PRO A CD    1 
ATOM   822  N  N     . LEU A 1 467  ? 143.709 123.818 169.068 1.00 67.04  ? 812  LEU A N     1 
ATOM   823  C  CA    . LEU A 1 467  ? 144.317 124.003 170.378 1.00 65.80  ? 812  LEU A CA    1 
ATOM   824  C  C     . LEU A 1 467  ? 145.191 125.250 170.452 1.00 67.78  ? 812  LEU A C     1 
ATOM   825  O  O     . LEU A 1 467  ? 146.041 125.350 171.342 1.00 70.21  ? 812  LEU A O     1 
ATOM   826  C  CB    . LEU A 1 467  ? 145.126 122.764 170.758 1.00 67.96  ? 812  LEU A CB    1 
ATOM   827  C  CG    . LEU A 1 467  ? 144.377 121.441 170.605 1.00 69.25  ? 812  LEU A CG    1 
ATOM   828  C  CD1   . LEU A 1 467  ? 145.338 120.268 170.670 1.00 68.33  ? 812  LEU A CD1   1 
ATOM   829  C  CD2   . LEU A 1 467  ? 143.294 121.315 171.661 1.00 67.20  ? 812  LEU A CD2   1 
ATOM   830  N  N     . GLU A 1 468  ? 145.003 126.199 169.541 1.00 58.94  ? 813  GLU A N     1 
ATOM   831  C  CA    . GLU A 1 468  ? 145.733 127.460 169.559 1.00 53.56  ? 813  GLU A CA    1 
ATOM   832  C  C     . GLU A 1 468  ? 144.836 128.564 170.096 1.00 60.38  ? 813  GLU A C     1 
ATOM   833  O  O     . GLU A 1 468  ? 143.684 128.695 169.670 1.00 69.30  ? 813  GLU A O     1 
ATOM   834  C  CB    . GLU A 1 468  ? 146.233 127.828 168.164 1.00 60.12  ? 813  GLU A CB    1 
ATOM   835  C  CG    . GLU A 1 468  ? 146.845 129.214 168.085 1.00 61.20  ? 813  GLU A CG    1 
ATOM   836  C  CD    . GLU A 1 468  ? 148.353 129.196 168.170 1.00 64.15  ? 813  GLU A CD    1 
ATOM   837  O  OE1   . GLU A 1 468  ? 148.920 128.116 168.422 1.00 62.77  ? 813  GLU A OE1   1 
ATOM   838  O  OE2   . GLU A 1 468  ? 148.972 130.263 167.987 1.00 62.52  ? 813  GLU A OE2   1 
ATOM   839  N  N     . LEU A 1 469  ? 145.365 129.355 171.025 1.00 44.99  ? 814  LEU A N     1 
ATOM   840  C  CA    . LEU A 1 469  ? 144.637 130.465 171.617 1.00 45.86  ? 814  LEU A CA    1 
ATOM   841  C  C     . LEU A 1 469  ? 145.468 131.732 171.499 1.00 51.49  ? 814  LEU A C     1 
ATOM   842  O  O     . LEU A 1 469  ? 146.699 131.682 171.460 1.00 58.14  ? 814  LEU A O     1 
ATOM   843  C  CB    . LEU A 1 469  ? 144.301 130.191 173.083 1.00 47.76  ? 814  LEU A CB    1 
ATOM   844  C  CG    . LEU A 1 469  ? 143.311 129.056 173.333 1.00 48.92  ? 814  LEU A CG    1 
ATOM   845  C  CD1   . LEU A 1 469  ? 143.118 128.850 174.818 1.00 53.69  ? 814  LEU A CD1   1 
ATOM   846  C  CD2   . LEU A 1 469  ? 141.986 129.344 172.658 1.00 45.20  ? 814  LEU A CD2   1 
ATOM   847  N  N     . PHE A 1 470  ? 144.787 132.873 171.432 1.00 48.93  ? 815  PHE A N     1 
ATOM   848  C  CA    . PHE A 1 470  ? 145.444 134.161 171.281 1.00 46.22  ? 815  PHE A CA    1 
ATOM   849  C  C     . PHE A 1 470  ? 144.950 135.124 172.346 1.00 50.53  ? 815  PHE A C     1 
ATOM   850  O  O     . PHE A 1 470  ? 143.764 135.132 172.689 1.00 56.22  ? 815  PHE A O     1 
ATOM   851  C  CB    . PHE A 1 470  ? 145.184 134.766 169.898 1.00 48.17  ? 815  PHE A CB    1 
ATOM   852  C  CG    . PHE A 1 470  ? 145.761 133.972 168.765 1.00 48.53  ? 815  PHE A CG    1 
ATOM   853  C  CD1   . PHE A 1 470  ? 147.106 134.051 168.461 1.00 48.50  ? 815  PHE A CD1   1 
ATOM   854  C  CD2   . PHE A 1 470  ? 144.952 133.160 167.994 1.00 49.57  ? 815  PHE A CD2   1 
ATOM   855  C  CE1   . PHE A 1 470  ? 147.635 133.327 167.418 1.00 43.90  ? 815  PHE A CE1   1 
ATOM   856  C  CE2   . PHE A 1 470  ? 145.477 132.433 166.951 1.00 54.18  ? 815  PHE A CE2   1 
ATOM   857  C  CZ    . PHE A 1 470  ? 146.820 132.517 166.663 1.00 48.35  ? 815  PHE A CZ    1 
ATOM   858  N  N     . LEU A 1 471  ? 145.866 135.933 172.867 1.00 50.66  ? 816  LEU A N     1 
ATOM   859  C  CA    . LEU A 1 471  ? 145.487 137.024 173.751 1.00 49.75  ? 816  LEU A CA    1 
ATOM   860  C  C     . LEU A 1 471  ? 144.794 138.124 172.960 1.00 56.28  ? 816  LEU A C     1 
ATOM   861  O  O     . LEU A 1 471  ? 145.132 138.387 171.804 1.00 62.30  ? 816  LEU A O     1 
ATOM   862  C  CB    . LEU A 1 471  ? 146.718 137.592 174.451 1.00 50.12  ? 816  LEU A CB    1 
ATOM   863  C  CG    . LEU A 1 471  ? 147.423 136.715 175.477 1.00 54.01  ? 816  LEU A CG    1 
ATOM   864  C  CD1   . LEU A 1 471  ? 148.900 137.045 175.506 1.00 54.61  ? 816  LEU A CD1   1 
ATOM   865  C  CD2   . LEU A 1 471  ? 146.805 136.922 176.843 1.00 54.40  ? 816  LEU A CD2   1 
ATOM   866  N  N     . VAL A 1 472  ? 143.813 138.771 173.590 1.00 59.50  ? 817  VAL A N     1 
ATOM   867  C  CA    . VAL A 1 472  ? 143.154 139.938 173.020 1.00 52.46  ? 817  VAL A CA    1 
ATOM   868  C  C     . VAL A 1 472  ? 142.894 140.939 174.134 1.00 59.29  ? 817  VAL A C     1 
ATOM   869  O  O     . VAL A 1 472  ? 142.999 140.626 175.320 1.00 69.59  ? 817  VAL A O     1 
ATOM   870  C  CB    . VAL A 1 472  ? 141.834 139.586 172.305 1.00 50.40  ? 817  VAL A CB    1 
ATOM   871  C  CG1   . VAL A 1 472  ? 142.115 139.042 170.923 1.00 59.88  ? 817  VAL A CG1   1 
ATOM   872  C  CG2   . VAL A 1 472  ? 141.048 138.586 173.123 1.00 61.97  ? 817  VAL A CG2   1 
ATOM   873  N  N     . ASP A 1 473  ? 142.557 142.163 173.736 1.00 69.81  ? 818  ASP A N     1 
ATOM   874  C  CA    . ASP A 1 473  ? 142.227 143.217 174.693 1.00 75.73  ? 818  ASP A CA    1 
ATOM   875  C  C     . ASP A 1 473  ? 140.713 143.290 174.904 1.00 79.21  ? 818  ASP A C     1 
ATOM   876  O  O     . ASP A 1 473  ? 140.063 144.309 174.683 1.00 78.77  ? 818  ASP A O     1 
ATOM   877  C  CB    . ASP A 1 473  ? 142.792 144.551 174.222 1.00 77.44  ? 818  ASP A CB    1 
ATOM   878  C  CG    . ASP A 1 473  ? 144.303 144.548 174.163 1.00 78.84  ? 818  ASP A CG    1 
ATOM   879  O  OD1   . ASP A 1 473  ? 144.893 143.447 174.156 1.00 76.00  ? 818  ASP A OD1   1 
ATOM   880  O  OD2   . ASP A 1 473  ? 144.901 145.643 174.125 1.00 82.56  ? 818  ASP A OD2   1 
ATOM   881  N  N     . GLU A 1 474  ? 140.157 142.164 175.342 1.00 76.12  ? 819  GLU A N     1 
ATOM   882  C  CA    . GLU A 1 474  ? 138.729 142.038 175.610 1.00 72.80  ? 819  GLU A CA    1 
ATOM   883  C  C     . GLU A 1 474  ? 138.571 141.414 176.988 1.00 75.42  ? 819  GLU A C     1 
ATOM   884  O  O     . GLU A 1 474  ? 138.813 140.217 177.161 1.00 78.60  ? 819  GLU A O     1 
ATOM   885  C  CB    . GLU A 1 474  ? 138.041 141.194 174.538 1.00 73.52  ? 819  GLU A CB    1 
ATOM   886  C  CG    . GLU A 1 474  ? 136.569 141.507 174.347 1.00 79.14  ? 819  GLU A CG    1 
ATOM   887  C  CD    . GLU A 1 474  ? 135.936 140.679 173.246 1.00 86.35  ? 819  GLU A CD    1 
ATOM   888  O  OE1   . GLU A 1 474  ? 136.409 139.549 173.001 1.00 84.56  ? 819  GLU A OE1   1 
ATOM   889  O  OE2   . GLU A 1 474  ? 134.966 141.159 172.623 1.00 86.53  ? 819  GLU A OE2   1 
ATOM   890  N  N     . CYS A 1 475  ? 138.177 142.223 177.967 1.00 84.88  ? 820  CYS A N     1 
ATOM   891  C  CA    . CYS A 1 475  ? 138.091 141.784 179.350 1.00 83.92  ? 820  CYS A CA    1 
ATOM   892  C  C     . CYS A 1 475  ? 136.839 142.362 179.984 1.00 83.82  ? 820  CYS A C     1 
ATOM   893  O  O     . CYS A 1 475  ? 136.319 143.387 179.536 1.00 89.63  ? 820  CYS A O     1 
ATOM   894  C  CB    . CYS A 1 475  ? 139.317 142.225 180.152 1.00 89.44  ? 820  CYS A CB    1 
ATOM   895  S  SG    . CYS A 1 475  ? 139.607 144.004 180.083 1.00 93.45  ? 820  CYS A SG    1 
ATOM   896  N  N     . GLU A 1 476  ? 136.361 141.701 181.035 1.00 89.51  ? 821  GLU A N     1 
ATOM   897  C  CA    . GLU A 1 476  ? 135.213 142.230 181.758 1.00 93.92  ? 821  GLU A CA    1 
ATOM   898  C  C     . GLU A 1 476  ? 135.090 141.566 183.121 1.00 95.40  ? 821  GLU A C     1 
ATOM   899  O  O     . GLU A 1 476  ? 135.674 140.509 183.372 1.00 100.05 ? 821  GLU A O     1 
ATOM   900  C  CB    . GLU A 1 476  ? 133.914 142.044 180.966 1.00 91.64  ? 821  GLU A CB    1 
ATOM   901  C  CG    . GLU A 1 476  ? 133.641 140.623 180.528 1.00 92.28  ? 821  GLU A CG    1 
ATOM   902  C  CD    . GLU A 1 476  ? 132.214 140.434 180.062 1.00 93.29  ? 821  GLU A CD    1 
ATOM   903  O  OE1   . GLU A 1 476  ? 131.348 141.236 180.467 1.00 91.38  ? 821  GLU A OE1   1 
ATOM   904  O  OE2   . GLU A 1 476  ? 131.957 139.490 179.288 1.00 95.42  ? 821  GLU A OE2   1 
ATOM   905  N  N     . ASP A 1 477  ? 134.324 142.209 183.997 1.00 96.52  ? 822  ASP A N     1 
ATOM   906  C  CA    . ASP A 1 477  ? 133.958 141.604 185.266 1.00 95.70  ? 822  ASP A CA    1 
ATOM   907  C  C     . ASP A 1 477  ? 132.861 140.570 185.051 1.00 95.15  ? 822  ASP A C     1 
ATOM   908  O  O     . ASP A 1 477  ? 132.053 140.674 184.125 1.00 94.21  ? 822  ASP A O     1 
ATOM   909  C  CB    . ASP A 1 477  ? 133.486 142.672 186.249 1.00 96.66  ? 822  ASP A CB    1 
ATOM   910  C  CG    . ASP A 1 477  ? 134.573 143.662 186.593 1.00 99.52  ? 822  ASP A CG    1 
ATOM   911  O  OD1   . ASP A 1 477  ? 135.642 143.614 185.950 1.00 101.14 ? 822  ASP A OD1   1 
ATOM   912  O  OD2   . ASP A 1 477  ? 134.358 144.493 187.498 1.00 98.95  ? 822  ASP A OD2   1 
ATOM   913  N  N     . MET A 1 478  ? 132.832 139.564 185.919 1.00 110.13 ? 823  MET A N     1 
ATOM   914  C  CA    . MET A 1 478  ? 131.870 138.488 185.744 1.00 111.13 ? 823  MET A CA    1 
ATOM   915  C  C     . MET A 1 478  ? 131.656 137.806 187.086 1.00 113.44 ? 823  MET A C     1 
ATOM   916  O  O     . MET A 1 478  ? 132.419 138.009 188.033 1.00 110.86 ? 823  MET A O     1 
ATOM   917  C  CB    . MET A 1 478  ? 132.352 137.496 184.682 1.00 113.25 ? 823  MET A CB    1 
ATOM   918  C  CG    . MET A 1 478  ? 131.256 136.737 183.967 1.00 113.16 ? 823  MET A CG    1 
ATOM   919  S  SD    . MET A 1 478  ? 131.868 136.068 182.411 1.00 118.38 ? 823  MET A SD    1 
ATOM   920  C  CE    . MET A 1 478  ? 130.381 136.099 181.421 1.00 112.63 ? 823  MET A CE    1 
ATOM   921  N  N     . GLN A 1 479  ? 130.596 137.008 187.162 1.00 123.46 ? 824  GLN A N     1 
ATOM   922  C  CA    . GLN A 1 479  ? 130.246 136.317 188.393 1.00 124.26 ? 824  GLN A CA    1 
ATOM   923  C  C     . GLN A 1 479  ? 130.807 134.900 188.400 1.00 122.92 ? 824  GLN A C     1 
ATOM   924  O  O     . GLN A 1 479  ? 131.010 134.284 187.351 1.00 122.20 ? 824  GLN A O     1 
ATOM   925  C  CB    . GLN A 1 479  ? 128.729 136.279 188.586 1.00 124.48 ? 824  GLN A CB    1 
ATOM   926  C  CG    . GLN A 1 479  ? 127.948 135.891 187.345 1.00 122.98 ? 824  GLN A CG    1 
ATOM   927  C  CD    . GLN A 1 479  ? 127.516 137.093 186.534 1.00 122.87 ? 824  GLN A CD    1 
ATOM   928  O  OE1   . GLN A 1 479  ? 128.347 137.848 186.031 1.00 122.47 ? 824  GLN A OE1   1 
ATOM   929  N  NE2   . GLN A 1 479  ? 126.209 137.280 186.404 1.00 123.13 ? 824  GLN A NE2   1 
ATOM   930  N  N     . LEU A 1 480  ? 131.053 134.388 189.608 1.00 114.83 ? 825  LEU A N     1 
ATOM   931  C  CA    . LEU A 1 480  ? 131.649 133.066 189.762 1.00 114.14 ? 825  LEU A CA    1 
ATOM   932  C  C     . LEU A 1 480  ? 130.742 131.950 189.265 1.00 113.91 ? 825  LEU A C     1 
ATOM   933  O  O     . LEU A 1 480  ? 131.240 130.873 188.924 1.00 117.45 ? 825  LEU A O     1 
ATOM   934  C  CB    . LEU A 1 480  ? 132.010 132.821 191.228 1.00 113.44 ? 825  LEU A CB    1 
ATOM   935  C  CG    . LEU A 1 480  ? 133.439 133.148 191.666 1.00 113.51 ? 825  LEU A CG    1 
ATOM   936  C  CD1   . LEU A 1 480  ? 134.420 132.161 191.064 1.00 115.89 ? 825  LEU A CD1   1 
ATOM   937  C  CD2   . LEU A 1 480  ? 133.818 134.569 191.291 1.00 114.80 ? 825  LEU A CD2   1 
ATOM   938  N  N     . SER A 1 481  ? 129.429 132.177 189.215 1.00 112.67 ? 826  SER A N     1 
ATOM   939  C  CA    . SER A 1 481  ? 128.516 131.126 188.782 1.00 114.48 ? 826  SER A CA    1 
ATOM   940  C  C     . SER A 1 481  ? 128.626 130.834 187.292 1.00 116.29 ? 826  SER A C     1 
ATOM   941  O  O     . SER A 1 481  ? 128.149 129.787 186.844 1.00 116.15 ? 826  SER A O     1 
ATOM   942  C  CB    . SER A 1 481  ? 127.076 131.504 189.130 1.00 116.56 ? 826  SER A CB    1 
ATOM   943  O  OG    . SER A 1 481  ? 126.568 132.460 188.217 1.00 116.58 ? 826  SER A OG    1 
ATOM   944  N  N     . TYR A 1 482  ? 129.237 131.730 186.518 1.00 122.31 ? 827  TYR A N     1 
ATOM   945  C  CA    . TYR A 1 482  ? 129.350 131.542 185.078 1.00 123.80 ? 827  TYR A CA    1 
ATOM   946  C  C     . TYR A 1 482  ? 130.499 130.627 184.677 1.00 120.47 ? 827  TYR A C     1 
ATOM   947  O  O     . TYR A 1 482  ? 130.554 130.205 183.518 1.00 118.97 ? 827  TYR A O     1 
ATOM   948  C  CB    . TYR A 1 482  ? 129.509 132.897 184.383 1.00 122.36 ? 827  TYR A CB    1 
ATOM   949  C  CG    . TYR A 1 482  ? 128.198 133.587 184.082 1.00 121.79 ? 827  TYR A CG    1 
ATOM   950  C  CD1   . TYR A 1 482  ? 127.014 132.869 184.012 1.00 122.15 ? 827  TYR A CD1   1 
ATOM   951  C  CD2   . TYR A 1 482  ? 128.146 134.957 183.867 1.00 120.29 ? 827  TYR A CD2   1 
ATOM   952  C  CE1   . TYR A 1 482  ? 125.816 133.495 183.736 1.00 121.99 ? 827  TYR A CE1   1 
ATOM   953  C  CE2   . TYR A 1 482  ? 126.953 135.591 183.589 1.00 121.56 ? 827  TYR A CE2   1 
ATOM   954  C  CZ    . TYR A 1 482  ? 125.790 134.855 183.526 1.00 121.75 ? 827  TYR A CZ    1 
ATOM   955  O  OH    . TYR A 1 482  ? 124.596 135.479 183.251 1.00 120.88 ? 827  TYR A OH    1 
ATOM   956  N  N     . ILE A 1 483  ? 131.412 130.312 185.594 1.00 107.26 ? 828  ILE A N     1 
ATOM   957  C  CA    . ILE A 1 483  ? 132.532 129.441 185.264 1.00 105.38 ? 828  ILE A CA    1 
ATOM   958  C  C     . ILE A 1 483  ? 132.027 128.017 185.083 1.00 105.90 ? 828  ILE A C     1 
ATOM   959  O  O     . ILE A 1 483  ? 131.318 127.478 185.941 1.00 106.72 ? 828  ILE A O     1 
ATOM   960  C  CB    . ILE A 1 483  ? 133.611 129.517 186.353 1.00 105.78 ? 828  ILE A CB    1 
ATOM   961  C  CG1   . ILE A 1 483  ? 134.404 130.816 186.224 1.00 105.69 ? 828  ILE A CG1   1 
ATOM   962  C  CG2   . ILE A 1 483  ? 134.539 128.321 186.272 1.00 106.55 ? 828  ILE A CG2   1 
ATOM   963  C  CD1   . ILE A 1 483  ? 134.949 131.324 187.532 1.00 103.49 ? 828  ILE A CD1   1 
ATOM   964  N  N     . HIS A 1 484  ? 132.392 127.399 183.961 1.00 109.45 ? 829  HIS A N     1 
ATOM   965  C  CA    . HIS A 1 484  ? 131.953 126.046 183.647 1.00 110.45 ? 829  HIS A CA    1 
ATOM   966  C  C     . HIS A 1 484  ? 132.947 124.997 184.135 1.00 110.01 ? 829  HIS A C     1 
ATOM   967  O  O     . HIS A 1 484  ? 132.556 124.027 184.792 1.00 108.50 ? 829  HIS A O     1 
ATOM   968  C  CB    . HIS A 1 484  ? 131.730 125.909 182.139 1.00 107.92 ? 829  HIS A CB    1 
ATOM   969  C  CG    . HIS A 1 484  ? 131.300 124.542 181.712 1.00 107.68 ? 829  HIS A CG    1 
ATOM   970  N  ND1   . HIS A 1 484  ? 130.063 124.019 182.025 1.00 109.37 ? 829  HIS A ND1   1 
ATOM   971  C  CD2   . HIS A 1 484  ? 131.938 123.591 180.990 1.00 107.76 ? 829  HIS A CD2   1 
ATOM   972  C  CE1   . HIS A 1 484  ? 129.960 122.804 181.517 1.00 111.05 ? 829  HIS A CE1   1 
ATOM   973  N  NE2   . HIS A 1 484  ? 131.084 122.520 180.884 1.00 109.93 ? 829  HIS A NE2   1 
ATOM   974  N  N     . SER A 1 485  ? 134.229 125.176 183.826 1.00 104.51 ? 830  SER A N     1 
ATOM   975  C  CA    . SER A 1 485  ? 135.254 124.237 184.258 1.00 102.84 ? 830  SER A CA    1 
ATOM   976  C  C     . SER A 1 485  ? 136.604 124.935 184.234 1.00 101.40 ? 830  SER A C     1 
ATOM   977  O  O     . SER A 1 485  ? 136.761 126.003 183.637 1.00 101.21 ? 830  SER A O     1 
ATOM   978  C  CB    . SER A 1 485  ? 135.285 122.989 183.372 1.00 102.37 ? 830  SER A CB    1 
ATOM   979  O  OG    . SER A 1 485  ? 135.830 123.289 182.100 1.00 99.74  ? 830  SER A OG    1 
ATOM   980  N  N     . LYS A 1 486  ? 137.578 124.314 184.891 1.00 99.65  ? 831  LYS A N     1 
ATOM   981  C  CA    . LYS A 1 486  ? 138.948 124.808 184.920 1.00 99.00  ? 831  LYS A CA    1 
ATOM   982  C  C     . LYS A 1 486  ? 139.739 124.109 183.821 1.00 100.10 ? 831  LYS A C     1 
ATOM   983  O  O     . LYS A 1 486  ? 139.810 122.876 183.791 1.00 103.08 ? 831  LYS A O     1 
ATOM   984  C  CB    . LYS A 1 486  ? 139.587 124.566 186.286 1.00 98.21  ? 831  LYS A CB    1 
ATOM   985  C  CG    . LYS A 1 486  ? 141.051 124.952 186.360 1.00 98.81  ? 831  LYS A CG    1 
ATOM   986  C  CD    . LYS A 1 486  ? 141.561 124.910 187.790 1.00 100.31 ? 831  LYS A CD    1 
ATOM   987  C  CE    . LYS A 1 486  ? 141.262 123.577 188.449 1.00 102.87 ? 831  LYS A CE    1 
ATOM   988  N  NZ    . LYS A 1 486  ? 141.845 123.497 189.816 1.00 102.99 ? 831  LYS A NZ    1 
ATOM   989  N  N     . VAL A 1 487  ? 140.330 124.895 182.925 1.00 86.99  ? 832  VAL A N     1 
ATOM   990  C  CA    . VAL A 1 487  ? 141.008 124.381 181.741 1.00 86.26  ? 832  VAL A CA    1 
ATOM   991  C  C     . VAL A 1 487  ? 142.469 124.798 181.802 1.00 86.17  ? 832  VAL A C     1 
ATOM   992  O  O     . VAL A 1 487  ? 142.775 125.970 182.045 1.00 88.38  ? 832  VAL A O     1 
ATOM   993  C  CB    . VAL A 1 487  ? 140.346 124.890 180.448 1.00 83.87  ? 832  VAL A CB    1 
ATOM   994  C  CG1   . VAL A 1 487  ? 141.318 124.815 179.286 1.00 81.95  ? 832  VAL A CG1   1 
ATOM   995  C  CG2   . VAL A 1 487  ? 139.092 124.090 180.149 1.00 84.93  ? 832  VAL A CG2   1 
ATOM   996  N  N     . LYS A 1 488  ? 143.366 123.840 181.587 1.00 77.97  ? 833  LYS A N     1 
ATOM   997  C  CA    . LYS A 1 488  ? 144.794 124.122 181.589 1.00 75.61  ? 833  LYS A CA    1 
ATOM   998  C  C     . LYS A 1 488  ? 145.210 124.742 180.262 1.00 74.02  ? 833  LYS A C     1 
ATOM   999  O  O     . LYS A 1 488  ? 144.954 124.176 179.195 1.00 78.56  ? 833  LYS A O     1 
ATOM   1000 C  CB    . LYS A 1 488  ? 145.591 122.844 181.844 1.00 75.29  ? 833  LYS A CB    1 
ATOM   1001 C  CG    . LYS A 1 488  ? 147.094 123.020 181.716 1.00 74.69  ? 833  LYS A CG    1 
ATOM   1002 C  CD    . LYS A 1 488  ? 147.819 121.688 181.789 1.00 77.56  ? 833  LYS A CD    1 
ATOM   1003 C  CE    . LYS A 1 488  ? 147.564 120.995 183.116 1.00 78.98  ? 833  LYS A CE    1 
ATOM   1004 N  NZ    . LYS A 1 488  ? 148.294 119.701 183.214 1.00 77.43  ? 833  LYS A NZ    1 
ATOM   1005 N  N     . VAL A 1 489  ? 145.849 125.906 180.330 1.00 61.62  ? 834  VAL A N     1 
ATOM   1006 C  CA    . VAL A 1 489  ? 146.375 126.596 179.160 1.00 58.14  ? 834  VAL A CA    1 
ATOM   1007 C  C     . VAL A 1 489  ? 147.831 126.937 179.434 1.00 66.30  ? 834  VAL A C     1 
ATOM   1008 O  O     . VAL A 1 489  ? 148.145 127.538 180.467 1.00 73.71  ? 834  VAL A O     1 
ATOM   1009 C  CB    . VAL A 1 489  ? 145.573 127.870 178.838 1.00 54.55  ? 834  VAL A CB    1 
ATOM   1010 C  CG1   . VAL A 1 489  ? 146.271 128.675 177.763 1.00 60.53  ? 834  VAL A CG1   1 
ATOM   1011 C  CG2   . VAL A 1 489  ? 144.163 127.516 178.410 1.00 62.21  ? 834  VAL A CG2   1 
ATOM   1012 N  N     . ILE A 1 490  ? 148.716 126.559 178.516 1.00 69.21  ? 835  ILE A N     1 
ATOM   1013 C  CA    . ILE A 1 490  ? 150.154 126.736 178.693 1.00 67.33  ? 835  ILE A CA    1 
ATOM   1014 C  C     . ILE A 1 490  ? 150.655 127.829 177.760 1.00 67.57  ? 835  ILE A C     1 
ATOM   1015 O  O     . ILE A 1 490  ? 150.196 127.952 176.617 1.00 64.47  ? 835  ILE A O     1 
ATOM   1016 C  CB    . ILE A 1 490  ? 150.926 125.424 178.460 1.00 64.09  ? 835  ILE A CB    1 
ATOM   1017 C  CG1   . ILE A 1 490  ? 150.332 124.652 177.285 1.00 67.77  ? 835  ILE A CG1   1 
ATOM   1018 C  CG2   . ILE A 1 490  ? 150.920 124.576 179.718 1.00 62.97  ? 835  ILE A CG2   1 
ATOM   1019 C  CD1   . ILE A 1 490  ? 150.977 123.306 177.056 1.00 72.21  ? 835  ILE A CD1   1 
ATOM   1020 N  N     . TYR A 1 491  ? 151.606 128.618 178.254 1.00 64.95  ? 836  TYR A N     1 
ATOM   1021 C  CA    . TYR A 1 491  ? 152.236 129.684 177.478 1.00 62.03  ? 836  TYR A CA    1 
ATOM   1022 C  C     . TYR A 1 491  ? 153.458 129.101 176.782 1.00 66.71  ? 836  TYR A C     1 
ATOM   1023 O  O     . TYR A 1 491  ? 154.563 129.086 177.325 1.00 68.27  ? 836  TYR A O     1 
ATOM   1024 C  CB    . TYR A 1 491  ? 152.603 130.857 178.377 1.00 57.35  ? 836  TYR A CB    1 
ATOM   1025 C  CG    . TYR A 1 491  ? 153.533 131.867 177.743 1.00 60.42  ? 836  TYR A CG    1 
ATOM   1026 C  CD1   . TYR A 1 491  ? 153.292 132.362 176.470 1.00 59.50  ? 836  TYR A CD1   1 
ATOM   1027 C  CD2   . TYR A 1 491  ? 154.653 132.324 178.421 1.00 64.25  ? 836  TYR A CD2   1 
ATOM   1028 C  CE1   . TYR A 1 491  ? 154.141 133.283 175.890 1.00 59.78  ? 836  TYR A CE1   1 
ATOM   1029 C  CE2   . TYR A 1 491  ? 155.507 133.245 177.849 1.00 66.32  ? 836  TYR A CE2   1 
ATOM   1030 C  CZ    . TYR A 1 491  ? 155.246 133.720 176.585 1.00 66.62  ? 836  TYR A CZ    1 
ATOM   1031 O  OH    . TYR A 1 491  ? 156.097 134.638 176.016 1.00 72.01  ? 836  TYR A OH    1 
ATOM   1032 N  N     . LYS A 1 492  ? 153.254 128.602 175.566 1.00 67.35  ? 837  LYS A N     1 
ATOM   1033 C  CA    . LYS A 1 492  ? 154.371 128.138 174.757 1.00 63.87  ? 837  LYS A CA    1 
ATOM   1034 C  C     . LYS A 1 492  ? 155.228 129.325 174.345 1.00 64.85  ? 837  LYS A C     1 
ATOM   1035 O  O     . LYS A 1 492  ? 154.715 130.333 173.854 1.00 66.44  ? 837  LYS A O     1 
ATOM   1036 C  CB    . LYS A 1 492  ? 153.862 127.392 173.526 1.00 63.49  ? 837  LYS A CB    1 
ATOM   1037 C  CG    . LYS A 1 492  ? 154.948 127.013 172.538 1.00 65.06  ? 837  LYS A CG    1 
ATOM   1038 C  CD    . LYS A 1 492  ? 154.408 126.099 171.455 1.00 66.53  ? 837  LYS A CD    1 
ATOM   1039 C  CE    . LYS A 1 492  ? 155.268 126.158 170.207 1.00 64.50  ? 837  LYS A CE    1 
ATOM   1040 N  NZ    . LYS A 1 492  ? 155.296 127.524 169.619 1.00 64.01  ? 837  LYS A NZ    1 
ATOM   1041 N  N     . ALA A 1 493  ? 156.535 129.206 174.543 1.00 73.03  ? 838  ALA A N     1 
ATOM   1042 C  CA    . ALA A 1 493  ? 157.415 130.332 174.298 1.00 73.94  ? 838  ALA A CA    1 
ATOM   1043 C  C     . ALA A 1 493  ? 158.529 129.940 173.338 1.00 76.31  ? 838  ALA A C     1 
ATOM   1044 O  O     . ALA A 1 493  ? 158.902 128.765 173.261 1.00 73.28  ? 838  ALA A O     1 
ATOM   1045 C  CB    . ALA A 1 493  ? 158.029 130.845 175.607 1.00 73.23  ? 838  ALA A CB    1 
ATOM   1046 N  N     . PRO A 1 494  ? 159.066 130.895 172.582 1.00 80.79  ? 839  PRO A N     1 
ATOM   1047 C  CA    . PRO A 1 494  ? 160.216 130.588 171.727 1.00 80.08  ? 839  PRO A CA    1 
ATOM   1048 C  C     . PRO A 1 494  ? 161.399 130.114 172.556 1.00 79.01  ? 839  PRO A C     1 
ATOM   1049 O  O     . PRO A 1 494  ? 161.676 130.639 173.636 1.00 81.25  ? 839  PRO A O     1 
ATOM   1050 C  CB    . PRO A 1 494  ? 160.512 131.922 171.031 1.00 75.82  ? 839  PRO A CB    1 
ATOM   1051 C  CG    . PRO A 1 494  ? 159.825 132.960 171.858 1.00 73.71  ? 839  PRO A CG    1 
ATOM   1052 C  CD    . PRO A 1 494  ? 158.620 132.289 172.428 1.00 73.70  ? 839  PRO A CD    1 
ATOM   1053 N  N     . SER A 1 495  ? 162.099 129.113 172.036 1.00 77.81  ? 840  SER A N     1 
ATOM   1054 C  CA    . SER A 1 495  ? 163.241 128.557 172.740 1.00 82.71  ? 840  SER A CA    1 
ATOM   1055 C  C     . SER A 1 495  ? 164.408 129.538 172.721 1.00 82.27  ? 840  SER A C     1 
ATOM   1056 O  O     . SER A 1 495  ? 164.424 130.515 171.969 1.00 78.58  ? 840  SER A O     1 
ATOM   1057 C  CB    . SER A 1 495  ? 163.660 127.229 172.113 1.00 81.68  ? 840  SER A CB    1 
ATOM   1058 O  OG    . SER A 1 495  ? 162.527 126.452 171.765 1.00 80.09  ? 840  SER A OG    1 
ATOM   1059 N  N     . GLU A 1 496  ? 165.396 129.269 173.577 1.00 89.99  ? 841  GLU A N     1 
ATOM   1060 C  CA    . GLU A 1 496  ? 166.593 130.101 173.590 1.00 90.12  ? 841  GLU A CA    1 
ATOM   1061 C  C     . GLU A 1 496  ? 167.387 129.952 172.300 1.00 89.73  ? 841  GLU A C     1 
ATOM   1062 O  O     . GLU A 1 496  ? 168.134 130.861 171.922 1.00 90.07  ? 841  GLU A O     1 
ATOM   1063 C  CB    . GLU A 1 496  ? 167.463 129.755 174.798 1.00 89.39  ? 841  GLU A CB    1 
ATOM   1064 C  CG    . GLU A 1 496  ? 167.132 130.553 176.050 1.00 92.71  ? 841  GLU A CG    1 
ATOM   1065 C  CD    . GLU A 1 496  ? 167.153 132.052 175.816 1.00 92.81  ? 841  GLU A CD    1 
ATOM   1066 O  OE1   . GLU A 1 496  ? 166.093 132.621 175.480 1.00 93.13  ? 841  GLU A OE1   1 
ATOM   1067 O  OE2   . GLU A 1 496  ? 168.232 132.662 175.967 1.00 91.85  ? 841  GLU A OE2   1 
ATOM   1068 N  N     . ASN A 1 497  ? 167.242 128.818 171.614 1.00 81.79  ? 842  ASN A N     1 
ATOM   1069 C  CA    . ASN A 1 497  ? 167.854 128.599 170.310 1.00 83.24  ? 842  ASN A CA    1 
ATOM   1070 C  C     . ASN A 1 497  ? 166.841 128.716 169.176 1.00 84.94  ? 842  ASN A C     1 
ATOM   1071 O  O     . ASN A 1 497  ? 166.945 128.004 168.172 1.00 87.37  ? 842  ASN A O     1 
ATOM   1072 C  CB    . ASN A 1 497  ? 168.548 127.237 170.270 1.00 83.40  ? 842  ASN A CB    1 
ATOM   1073 C  CG    . ASN A 1 497  ? 167.573 126.083 170.378 1.00 87.27  ? 842  ASN A CG    1 
ATOM   1074 O  OD1   . ASN A 1 497  ? 166.495 126.217 170.955 1.00 83.75  ? 842  ASN A OD1   1 
ATOM   1075 N  ND2   . ASN A 1 497  ? 167.947 124.939 169.816 1.00 87.83  ? 842  ASN A ND2   1 
ATOM   1076 N  N     . TRP A 1 498  ? 165.858 129.610 169.322 1.00 68.67  ? 843  TRP A N     1 
ATOM   1077 C  CA    . TRP A 1 498  ? 164.826 129.759 168.301 1.00 60.60  ? 843  TRP A CA    1 
ATOM   1078 C  C     . TRP A 1 498  ? 165.414 130.161 166.957 1.00 63.73  ? 843  TRP A C     1 
ATOM   1079 O  O     . TRP A 1 498  ? 164.848 129.833 165.910 1.00 74.41  ? 843  TRP A O     1 
ATOM   1080 C  CB    . TRP A 1 498  ? 163.790 130.787 168.753 1.00 61.42  ? 843  TRP A CB    1 
ATOM   1081 C  CG    . TRP A 1 498  ? 162.733 131.063 167.736 1.00 62.73  ? 843  TRP A CG    1 
ATOM   1082 C  CD1   . TRP A 1 498  ? 161.538 130.427 167.606 1.00 65.08  ? 843  TRP A CD1   1 
ATOM   1083 C  CD2   . TRP A 1 498  ? 162.776 132.053 166.704 1.00 65.41  ? 843  TRP A CD2   1 
ATOM   1084 N  NE1   . TRP A 1 498  ? 160.832 130.957 166.557 1.00 67.73  ? 843  TRP A NE1   1 
ATOM   1085 C  CE2   . TRP A 1 498  ? 161.572 131.958 165.986 1.00 64.04  ? 843  TRP A CE2   1 
ATOM   1086 C  CE3   . TRP A 1 498  ? 163.717 133.009 166.316 1.00 67.25  ? 843  TRP A CE3   1 
ATOM   1087 C  CZ2   . TRP A 1 498  ? 161.284 132.781 164.904 1.00 62.61  ? 843  TRP A CZ2   1 
ATOM   1088 C  CZ3   . TRP A 1 498  ? 163.429 133.825 165.244 1.00 63.21  ? 843  TRP A CZ3   1 
ATOM   1089 C  CH2   . TRP A 1 498  ? 162.224 133.706 164.549 1.00 61.35  ? 843  TRP A CH2   1 
ATOM   1090 N  N     . ALA A 1 499  ? 166.543 130.867 166.962 1.00 66.87  ? 844  ALA A N     1 
ATOM   1091 C  CA    . ALA A 1 499  ? 167.178 131.258 165.711 1.00 73.63  ? 844  ALA A CA    1 
ATOM   1092 C  C     . ALA A 1 499  ? 167.841 130.090 164.995 1.00 71.50  ? 844  ALA A C     1 
ATOM   1093 O  O     . ALA A 1 499  ? 168.237 130.245 163.836 1.00 70.59  ? 844  ALA A O     1 
ATOM   1094 C  CB    . ALA A 1 499  ? 168.209 132.357 165.969 1.00 70.90  ? 844  ALA A CB    1 
ATOM   1095 N  N     . MET A 1 500  ? 167.969 128.937 165.644 1.00 72.44  ? 845  MET A N     1 
ATOM   1096 C  CA    . MET A 1 500  ? 168.663 127.782 165.085 1.00 75.01  ? 845  MET A CA    1 
ATOM   1097 C  C     . MET A 1 500  ? 167.768 126.550 165.122 1.00 75.25  ? 845  MET A C     1 
ATOM   1098 O  O     . MET A 1 500  ? 168.177 125.463 165.532 1.00 72.86  ? 845  MET A O     1 
ATOM   1099 C  CB    . MET A 1 500  ? 169.966 127.523 165.832 1.00 75.24  ? 845  MET A CB    1 
ATOM   1100 C  CG    . MET A 1 500  ? 170.921 128.702 165.837 1.00 76.29  ? 845  MET A CG    1 
ATOM   1101 S  SD    . MET A 1 500  ? 172.254 128.523 164.640 1.00 89.70  ? 845  MET A SD    1 
ATOM   1102 C  CE    . MET A 1 500  ? 173.155 130.047 164.909 1.00 77.46  ? 845  MET A CE    1 
ATOM   1103 N  N     . GLU A 1 501  ? 166.519 126.709 164.687 1.00 73.67  ? 846  GLU A N     1 
ATOM   1104 C  CA    . GLU A 1 501  ? 165.585 125.592 164.646 1.00 73.31  ? 846  GLU A CA    1 
ATOM   1105 C  C     . GLU A 1 501  ? 165.064 125.363 163.234 1.00 76.75  ? 846  GLU A C     1 
ATOM   1106 O  O     . GLU A 1 501  ? 163.859 125.189 163.034 1.00 78.18  ? 846  GLU A O     1 
ATOM   1107 C  CB    . GLU A 1 501  ? 164.417 125.827 165.603 1.00 67.86  ? 846  GLU A CB    1 
ATOM   1108 C  CG    . GLU A 1 501  ? 164.723 125.493 167.050 1.00 72.70  ? 846  GLU A CG    1 
ATOM   1109 C  CD    . GLU A 1 501  ? 163.470 125.345 167.888 1.00 78.92  ? 846  GLU A CD    1 
ATOM   1110 O  OE1   . GLU A 1 501  ? 162.397 125.798 167.438 1.00 80.40  ? 846  GLU A OE1   1 
ATOM   1111 O  OE2   . GLU A 1 501  ? 163.557 124.778 168.997 1.00 75.15  ? 846  GLU A OE2   1 
ATOM   1112 N  N     . GLY A 1 502  ? 165.957 125.368 162.249 1.00 74.59  ? 847  GLY A N     1 
ATOM   1113 C  CA    . GLY A 1 502  ? 165.551 125.136 160.879 1.00 68.50  ? 847  GLY A CA    1 
ATOM   1114 C  C     . GLY A 1 502  ? 165.525 123.667 160.514 1.00 73.97  ? 847  GLY A C     1 
ATOM   1115 O  O     . GLY A 1 502  ? 166.562 123.080 160.195 1.00 74.84  ? 847  GLY A O     1 
ATOM   1116 N  N     . GLY A 1 503  ? 164.342 123.062 160.553 1.00 81.38  ? 848  GLY A N     1 
ATOM   1117 C  CA    . GLY A 1 503  ? 164.207 121.653 160.244 1.00 83.11  ? 848  GLY A CA    1 
ATOM   1118 C  C     . GLY A 1 503  ? 164.169 120.776 161.478 1.00 86.40  ? 848  GLY A C     1 
ATOM   1119 O  O     . GLY A 1 503  ? 165.195 120.568 162.132 1.00 82.85  ? 848  GLY A O     1 
ATOM   1120 N  N     . MET A 1 504  ? 162.991 120.256 161.807 1.00 98.82  ? 849  MET A N     1 
ATOM   1121 C  CA    . MET A 1 504  ? 162.834 119.395 162.974 1.00 96.68  ? 849  MET A CA    1 
ATOM   1122 C  C     . MET A 1 504  ? 162.189 118.063 162.605 1.00 97.40  ? 849  MET A C     1 
ATOM   1123 O  O     . MET A 1 504  ? 162.067 117.170 163.443 1.00 96.80  ? 849  MET A O     1 
ATOM   1124 C  CB    . MET A 1 504  ? 162.024 120.119 164.060 1.00 99.14  ? 849  MET A CB    1 
ATOM   1125 C  CG    . MET A 1 504  ? 160.602 120.556 163.678 1.00 102.97 ? 849  MET A CG    1 
ATOM   1126 S  SD    . MET A 1 504  ? 159.371 119.271 163.355 1.00 108.43 ? 849  MET A SD    1 
ATOM   1127 C  CE    . MET A 1 504  ? 159.397 118.373 164.904 1.00 99.49  ? 849  MET A CE    1 
ATOM   1128 N  N     . GLY A 1 515  ? 149.452 116.408 176.364 1.00 97.31  ? 860  GLY A N     1 
ATOM   1129 C  CA    . GLY A 1 515  ? 150.056 116.772 175.096 1.00 99.49  ? 860  GLY A CA    1 
ATOM   1130 C  C     . GLY A 1 515  ? 149.098 117.472 174.152 1.00 100.62 ? 860  GLY A C     1 
ATOM   1131 O  O     . GLY A 1 515  ? 149.507 118.012 173.125 1.00 100.49 ? 860  GLY A O     1 
ATOM   1132 N  N     . LYS A 1 516  ? 147.811 117.461 174.503 1.00 97.06  ? 861  LYS A N     1 
ATOM   1133 C  CA    . LYS A 1 516  ? 146.771 118.085 173.695 1.00 96.72  ? 861  LYS A CA    1 
ATOM   1134 C  C     . LYS A 1 516  ? 146.111 119.262 174.405 1.00 97.68  ? 861  LYS A C     1 
ATOM   1135 O  O     . LYS A 1 516  ? 145.031 119.701 173.997 1.00 98.11  ? 861  LYS A O     1 
ATOM   1136 C  CB    . LYS A 1 516  ? 145.720 117.049 173.297 1.00 94.43  ? 861  LYS A CB    1 
ATOM   1137 C  CG    . LYS A 1 516  ? 145.091 116.326 174.475 1.00 93.50  ? 861  LYS A CG    1 
ATOM   1138 C  CD    . LYS A 1 516  ? 143.653 116.767 174.690 1.00 94.16  ? 861  LYS A CD    1 
ATOM   1139 C  CE    . LYS A 1 516  ? 143.126 116.287 176.032 1.00 94.39  ? 861  LYS A CE    1 
ATOM   1140 N  NZ    . LYS A 1 516  ? 141.745 116.778 176.294 1.00 95.30  ? 861  LYS A NZ    1 
ATOM   1141 N  N     . THR A 1 517  ? 146.734 119.781 175.459 1.00 84.73  ? 862  THR A N     1 
ATOM   1142 C  CA    . THR A 1 517  ? 146.166 120.903 176.186 1.00 81.36  ? 862  THR A CA    1 
ATOM   1143 C  C     . THR A 1 517  ? 146.302 122.192 175.381 1.00 83.20  ? 862  THR A C     1 
ATOM   1144 O  O     . THR A 1 517  ? 147.160 122.322 174.504 1.00 84.24  ? 862  THR A O     1 
ATOM   1145 C  CB    . THR A 1 517  ? 146.849 121.067 177.542 1.00 81.15  ? 862  THR A CB    1 
ATOM   1146 O  OG1   . THR A 1 517  ? 148.170 121.586 177.349 1.00 80.51  ? 862  THR A OG1   1 
ATOM   1147 C  CG2   . THR A 1 517  ? 146.937 119.727 178.255 1.00 82.80  ? 862  THR A CG2   1 
ATOM   1148 N  N     . TYR A 1 518  ? 145.434 123.154 175.692 1.00 73.55  ? 863  TYR A N     1 
ATOM   1149 C  CA    . TYR A 1 518  ? 145.469 124.443 175.016 1.00 69.49  ? 863  TYR A CA    1 
ATOM   1150 C  C     . TYR A 1 518  ? 146.791 125.150 175.279 1.00 69.27  ? 863  TYR A C     1 
ATOM   1151 O  O     . TYR A 1 518  ? 147.319 125.125 176.394 1.00 72.48  ? 863  TYR A O     1 
ATOM   1152 C  CB    . TYR A 1 518  ? 144.321 125.331 175.492 1.00 66.93  ? 863  TYR A CB    1 
ATOM   1153 C  CG    . TYR A 1 518  ? 142.937 124.878 175.101 1.00 66.13  ? 863  TYR A CG    1 
ATOM   1154 C  CD1   . TYR A 1 518  ? 142.270 123.909 175.830 1.00 70.91  ? 863  TYR A CD1   1 
ATOM   1155 C  CD2   . TYR A 1 518  ? 142.286 125.443 174.017 1.00 66.49  ? 863  TYR A CD2   1 
ATOM   1156 C  CE1   . TYR A 1 518  ? 141.000 123.504 175.482 1.00 72.97  ? 863  TYR A CE1   1 
ATOM   1157 C  CE2   . TYR A 1 518  ? 141.018 125.045 173.661 1.00 68.35  ? 863  TYR A CE2   1 
ATOM   1158 C  CZ    . TYR A 1 518  ? 140.379 124.076 174.396 1.00 72.86  ? 863  TYR A CZ    1 
ATOM   1159 O  OH    . TYR A 1 518  ? 139.113 123.676 174.043 1.00 73.86  ? 863  TYR A OH    1 
ATOM   1160 N  N     . PHE A 1 519  ? 147.323 125.797 174.249 1.00 60.93  ? 864  PHE A N     1 
ATOM   1161 C  CA    . PHE A 1 519  ? 148.518 126.608 174.402 1.00 63.57  ? 864  PHE A CA    1 
ATOM   1162 C  C     . PHE A 1 519  ? 148.327 127.914 173.653 1.00 64.21  ? 864  PHE A C     1 
ATOM   1163 O  O     . PHE A 1 519  ? 147.624 127.967 172.642 1.00 74.02  ? 864  PHE A O     1 
ATOM   1164 C  CB    . PHE A 1 519  ? 149.773 125.887 173.897 1.00 66.64  ? 864  PHE A CB    1 
ATOM   1165 C  CG    . PHE A 1 519  ? 149.843 125.758 172.405 1.00 68.07  ? 864  PHE A CG    1 
ATOM   1166 C  CD1   . PHE A 1 519  ? 149.095 124.802 171.743 1.00 69.84  ? 864  PHE A CD1   1 
ATOM   1167 C  CD2   . PHE A 1 519  ? 150.668 126.582 171.665 1.00 65.75  ? 864  PHE A CD2   1 
ATOM   1168 C  CE1   . PHE A 1 519  ? 149.162 124.680 170.373 1.00 65.37  ? 864  PHE A CE1   1 
ATOM   1169 C  CE2   . PHE A 1 519  ? 150.739 126.463 170.297 1.00 65.13  ? 864  PHE A CE2   1 
ATOM   1170 C  CZ    . PHE A 1 519  ? 149.986 125.510 169.650 1.00 65.19  ? 864  PHE A CZ    1 
ATOM   1171 N  N     . TYR A 1 520  ? 148.951 128.969 174.164 1.00 50.92  ? 865  TYR A N     1 
ATOM   1172 C  CA    . TYR A 1 520  ? 148.886 130.276 173.527 1.00 54.72  ? 865  TYR A CA    1 
ATOM   1173 C  C     . TYR A 1 520  ? 150.287 130.845 173.389 1.00 55.53  ? 865  TYR A C     1 
ATOM   1174 O  O     . TYR A 1 520  ? 151.118 130.692 174.287 1.00 69.24  ? 865  TYR A O     1 
ATOM   1175 C  CB    . TYR A 1 520  ? 147.985 131.245 174.311 1.00 59.35  ? 865  TYR A CB    1 
ATOM   1176 C  CG    . TYR A 1 520  ? 148.628 131.917 175.502 1.00 55.90  ? 865  TYR A CG    1 
ATOM   1177 C  CD1   . TYR A 1 520  ? 148.599 131.326 176.754 1.00 57.72  ? 865  TYR A CD1   1 
ATOM   1178 C  CD2   . TYR A 1 520  ? 149.239 133.157 175.380 1.00 54.32  ? 865  TYR A CD2   1 
ATOM   1179 C  CE1   . TYR A 1 520  ? 149.176 131.941 177.844 1.00 59.65  ? 865  TYR A CE1   1 
ATOM   1180 C  CE2   . TYR A 1 520  ? 149.820 133.776 176.463 1.00 50.28  ? 865  TYR A CE2   1 
ATOM   1181 C  CZ    . TYR A 1 520  ? 149.784 133.165 177.692 1.00 57.33  ? 865  TYR A CZ    1 
ATOM   1182 O  OH    . TYR A 1 520  ? 150.360 133.780 178.777 1.00 62.51  ? 865  TYR A OH    1 
ATOM   1183 N  N     . GLN A 1 521  ? 150.548 131.494 172.255 1.00 38.83  ? 866  GLN A N     1 
ATOM   1184 C  CA    . GLN A 1 521  ? 151.857 132.093 172.034 1.00 47.50  ? 866  GLN A CA    1 
ATOM   1185 C  C     . GLN A 1 521  ? 151.826 133.496 171.449 1.00 58.80  ? 866  GLN A C     1 
ATOM   1186 O  O     . GLN A 1 521  ? 152.870 134.154 171.460 1.00 63.13  ? 866  GLN A O     1 
ATOM   1187 C  CB    . GLN A 1 521  ? 152.709 131.199 171.120 1.00 47.97  ? 866  GLN A CB    1 
ATOM   1188 C  CG    . GLN A 1 521  ? 152.095 130.918 169.761 1.00 59.59  ? 866  GLN A CG    1 
ATOM   1189 C  CD    . GLN A 1 521  ? 152.997 130.080 168.875 1.00 58.85  ? 866  GLN A CD    1 
ATOM   1190 O  OE1   . GLN A 1 521  ? 154.211 130.042 169.064 1.00 55.11  ? 866  GLN A OE1   1 
ATOM   1191 N  NE2   . GLN A 1 521  ? 152.406 129.404 167.900 1.00 49.61  ? 866  GLN A NE2   1 
ATOM   1192 N  N     . LEU A 1 522  ? 150.693 133.986 170.949 1.00 45.87  ? 867  LEU A N     1 
ATOM   1193 C  CA    . LEU A 1 522  ? 150.663 135.273 170.272 1.00 40.95  ? 867  LEU A CA    1 
ATOM   1194 C  C     . LEU A 1 522  ? 149.440 136.074 170.699 1.00 48.02  ? 867  LEU A C     1 
ATOM   1195 O  O     . LEU A 1 522  ? 148.424 135.526 171.128 1.00 56.72  ? 867  LEU A O     1 
ATOM   1196 C  CB    . LEU A 1 522  ? 150.679 135.102 168.748 1.00 46.03  ? 867  LEU A CB    1 
ATOM   1197 C  CG    . LEU A 1 522  ? 152.033 134.735 168.136 1.00 34.83  ? 867  LEU A CG    1 
ATOM   1198 C  CD1   . LEU A 1 522  ? 151.911 134.543 166.640 1.00 35.01  ? 867  LEU A CD1   1 
ATOM   1199 C  CD2   . LEU A 1 522  ? 153.067 135.794 168.453 1.00 44.56  ? 867  LEU A CD2   1 
ATOM   1200 N  N     . TRP A 1 523  ? 149.564 137.391 170.565 1.00 56.06  ? 868  TRP A N     1 
ATOM   1201 C  CA    . TRP A 1 523  ? 148.540 138.364 170.921 1.00 48.78  ? 868  TRP A CA    1 
ATOM   1202 C  C     . TRP A 1 523  ? 147.941 138.934 169.643 1.00 45.83  ? 868  TRP A C     1 
ATOM   1203 O  O     . TRP A 1 523  ? 148.677 139.344 168.740 1.00 55.20  ? 868  TRP A O     1 
ATOM   1204 C  CB    . TRP A 1 523  ? 149.146 139.477 171.780 1.00 43.94  ? 868  TRP A CB    1 
ATOM   1205 C  CG    . TRP A 1 523  ? 148.243 140.632 172.068 1.00 41.65  ? 868  TRP A CG    1 
ATOM   1206 C  CD1   . TRP A 1 523  ? 147.394 140.759 173.124 1.00 50.10  ? 868  TRP A CD1   1 
ATOM   1207 C  CD2   . TRP A 1 523  ? 148.122 141.839 171.308 1.00 53.34  ? 868  TRP A CD2   1 
ATOM   1208 N  NE1   . TRP A 1 523  ? 146.738 141.964 173.063 1.00 58.07  ? 868  TRP A NE1   1 
ATOM   1209 C  CE2   . TRP A 1 523  ? 147.168 142.646 171.956 1.00 55.78  ? 868  TRP A CE2   1 
ATOM   1210 C  CE3   . TRP A 1 523  ? 148.721 142.313 170.138 1.00 57.21  ? 868  TRP A CE3   1 
ATOM   1211 C  CZ2   . TRP A 1 523  ? 146.800 143.897 171.474 1.00 52.28  ? 868  TRP A CZ2   1 
ATOM   1212 C  CZ3   . TRP A 1 523  ? 148.353 143.556 169.661 1.00 53.86  ? 868  TRP A CZ3   1 
ATOM   1213 C  CH2   . TRP A 1 523  ? 147.403 144.334 170.328 1.00 54.59  ? 868  TRP A CH2   1 
ATOM   1214 N  N     . TYR A 1 524  ? 146.615 138.968 169.572 1.00 35.04  ? 869  TYR A N     1 
ATOM   1215 C  CA    . TYR A 1 524  ? 145.894 139.239 168.336 1.00 30.39  ? 869  TYR A CA    1 
ATOM   1216 C  C     . TYR A 1 524  ? 145.209 140.597 168.394 1.00 44.85  ? 869  TYR A C     1 
ATOM   1217 O  O     . TYR A 1 524  ? 144.480 140.891 169.347 1.00 55.13  ? 869  TYR A O     1 
ATOM   1218 C  CB    . TYR A 1 524  ? 144.862 138.145 168.078 1.00 36.92  ? 869  TYR A CB    1 
ATOM   1219 C  CG    . TYR A 1 524  ? 144.149 138.250 166.755 1.00 40.56  ? 869  TYR A CG    1 
ATOM   1220 C  CD1   . TYR A 1 524  ? 144.855 138.308 165.568 1.00 48.80  ? 869  TYR A CD1   1 
ATOM   1221 C  CD2   . TYR A 1 524  ? 142.767 138.267 166.694 1.00 39.37  ? 869  TYR A CD2   1 
ATOM   1222 C  CE1   . TYR A 1 524  ? 144.205 138.393 164.358 1.00 47.23  ? 869  TYR A CE1   1 
ATOM   1223 C  CE2   . TYR A 1 524  ? 142.110 138.351 165.489 1.00 37.82  ? 869  TYR A CE2   1 
ATOM   1224 C  CZ    . TYR A 1 524  ? 142.832 138.413 164.326 1.00 43.46  ? 869  TYR A CZ    1 
ATOM   1225 O  OH    . TYR A 1 524  ? 142.174 138.498 163.125 1.00 55.23  ? 869  TYR A OH    1 
ATOM   1226 N  N     . ASP A 1 525  ? 145.439 141.413 167.370 1.00 52.98  ? 870  ASP A N     1 
ATOM   1227 C  CA    . ASP A 1 525  ? 144.759 142.689 167.187 1.00 52.01  ? 870  ASP A CA    1 
ATOM   1228 C  C     . ASP A 1 525  ? 143.720 142.497 166.088 1.00 53.08  ? 870  ASP A C     1 
ATOM   1229 O  O     . ASP A 1 525  ? 144.073 142.281 164.922 1.00 58.29  ? 870  ASP A O     1 
ATOM   1230 C  CB    . ASP A 1 525  ? 145.754 143.791 166.833 1.00 55.15  ? 870  ASP A CB    1 
ATOM   1231 C  CG    . ASP A 1 525  ? 145.178 145.181 167.013 1.00 66.13  ? 870  ASP A CG    1 
ATOM   1232 O  OD1   . ASP A 1 525  ? 143.943 145.305 167.146 1.00 69.59  ? 870  ASP A OD1   1 
ATOM   1233 O  OD2   . ASP A 1 525  ? 145.962 146.153 167.024 1.00 65.93  ? 870  ASP A OD2   1 
ATOM   1234 N  N     . GLN A 1 526  ? 142.442 142.578 166.471 1.00 57.47  ? 871  GLN A N     1 
ATOM   1235 C  CA    . GLN A 1 526  ? 141.353 142.185 165.581 1.00 59.42  ? 871  GLN A CA    1 
ATOM   1236 C  C     . GLN A 1 526  ? 141.124 143.207 164.476 1.00 63.17  ? 871  GLN A C     1 
ATOM   1237 O  O     . GLN A 1 526  ? 140.826 142.836 163.335 1.00 66.97  ? 871  GLN A O     1 
ATOM   1238 C  CB    . GLN A 1 526  ? 140.069 141.985 166.389 1.00 60.68  ? 871  GLN A CB    1 
ATOM   1239 C  CG    . GLN A 1 526  ? 139.731 140.532 166.685 1.00 68.59  ? 871  GLN A CG    1 
ATOM   1240 C  CD    . GLN A 1 526  ? 138.836 140.371 167.899 1.00 70.04  ? 871  GLN A CD    1 
ATOM   1241 O  OE1   . GLN A 1 526  ? 138.466 141.350 168.548 1.00 67.31  ? 871  GLN A OE1   1 
ATOM   1242 N  NE2   . GLN A 1 526  ? 138.487 139.130 168.216 1.00 62.97  ? 871  GLN A NE2   1 
ATOM   1243 N  N     . ASP A 1 527  ? 141.236 144.497 164.798 1.00 69.44  ? 872  ASP A N     1 
ATOM   1244 C  CA    . ASP A 1 527  ? 140.925 145.533 163.818 1.00 70.52  ? 872  ASP A CA    1 
ATOM   1245 C  C     . ASP A 1 527  ? 141.865 145.462 162.622 1.00 71.28  ? 872  ASP A C     1 
ATOM   1246 O  O     . ASP A 1 527  ? 141.429 145.541 161.469 1.00 72.81  ? 872  ASP A O     1 
ATOM   1247 C  CB    . ASP A 1 527  ? 140.995 146.913 164.474 1.00 70.29  ? 872  ASP A CB    1 
ATOM   1248 C  CG    . ASP A 1 527  ? 140.290 146.959 165.813 1.00 76.67  ? 872  ASP A CG    1 
ATOM   1249 O  OD1   . ASP A 1 527  ? 139.042 146.914 165.832 1.00 78.64  ? 872  ASP A OD1   1 
ATOM   1250 O  OD2   . ASP A 1 527  ? 140.983 147.045 166.849 1.00 77.07  ? 872  ASP A OD2   1 
ATOM   1251 N  N     . TYR A 1 528  ? 143.160 145.300 162.879 1.00 58.22  ? 873  TYR A N     1 
ATOM   1252 C  CA    . TYR A 1 528  ? 144.168 145.294 161.829 1.00 51.78  ? 873  TYR A CA    1 
ATOM   1253 C  C     . TYR A 1 528  ? 144.690 143.900 161.512 1.00 63.71  ? 873  TYR A C     1 
ATOM   1254 O  O     . TYR A 1 528  ? 145.581 143.768 160.668 1.00 68.27  ? 873  TYR A O     1 
ATOM   1255 C  CB    . TYR A 1 528  ? 145.332 146.206 162.219 1.00 48.62  ? 873  TYR A CB    1 
ATOM   1256 C  CG    . TYR A 1 528  ? 144.893 147.522 162.814 1.00 57.97  ? 873  TYR A CG    1 
ATOM   1257 C  CD1   . TYR A 1 528  ? 143.849 148.245 162.254 1.00 65.78  ? 873  TYR A CD1   1 
ATOM   1258 C  CD2   . TYR A 1 528  ? 145.520 148.042 163.934 1.00 61.05  ? 873  TYR A CD2   1 
ATOM   1259 C  CE1   . TYR A 1 528  ? 143.442 149.445 162.794 1.00 65.05  ? 873  TYR A CE1   1 
ATOM   1260 C  CE2   . TYR A 1 528  ? 145.121 149.244 164.481 1.00 62.27  ? 873  TYR A CE2   1 
ATOM   1261 C  CZ    . TYR A 1 528  ? 144.080 149.941 163.907 1.00 66.01  ? 873  TYR A CZ    1 
ATOM   1262 O  OH    . TYR A 1 528  ? 143.678 151.139 164.448 1.00 69.38  ? 873  TYR A OH    1 
ATOM   1263 N  N     . ALA A 1 529  ? 144.157 142.866 162.161 1.00 62.66  ? 874  ALA A N     1 
ATOM   1264 C  CA    . ALA A 1 529  ? 144.583 141.482 161.961 1.00 52.66  ? 874  ALA A CA    1 
ATOM   1265 C  C     . ALA A 1 529  ? 146.088 141.338 162.168 1.00 47.37  ? 874  ALA A C     1 
ATOM   1266 O  O     . ALA A 1 529  ? 146.821 140.862 161.301 1.00 45.52  ? 874  ALA A O     1 
ATOM   1267 C  CB    . ALA A 1 529  ? 144.169 140.974 160.580 1.00 51.39  ? 874  ALA A CB    1 
ATOM   1268 N  N     . ARG A 1 530  ? 146.542 141.763 163.343 1.00 45.23  ? 875  ARG A N     1 
ATOM   1269 C  CA    . ARG A 1 530  ? 147.962 141.766 163.669 1.00 41.69  ? 875  ARG A CA    1 
ATOM   1270 C  C     . ARG A 1 530  ? 148.271 140.697 164.707 1.00 52.10  ? 875  ARG A C     1 
ATOM   1271 O  O     . ARG A 1 530  ? 147.481 140.465 165.622 1.00 70.26  ? 875  ARG A O     1 
ATOM   1272 C  CB    . ARG A 1 530  ? 148.403 143.131 164.200 1.00 39.52  ? 875  ARG A CB    1 
ATOM   1273 C  CG    . ARG A 1 530  ? 148.894 144.081 163.131 1.00 46.07  ? 875  ARG A CG    1 
ATOM   1274 C  CD    . ARG A 1 530  ? 149.062 145.479 163.682 1.00 49.40  ? 875  ARG A CD    1 
ATOM   1275 N  NE    . ARG A 1 530  ? 150.315 145.629 164.409 1.00 47.03  ? 875  ARG A NE    1 
ATOM   1276 C  CZ    . ARG A 1 530  ? 151.405 146.189 163.906 1.00 47.18  ? 875  ARG A CZ    1 
ATOM   1277 N  NH1   . ARG A 1 530  ? 151.428 146.670 162.674 1.00 47.53  ? 875  ARG A NH1   1 
ATOM   1278 N  NH2   . ARG A 1 530  ? 152.498 146.272 164.658 1.00 44.08  ? 875  ARG A NH2   1 
ATOM   1279 N  N     . PHE A 1 531  ? 149.417 140.044 164.560 1.00 34.98  ? 876  PHE A N     1 
ATOM   1280 C  CA    . PHE A 1 531  ? 149.926 139.117 165.560 1.00 27.30  ? 876  PHE A CA    1 
ATOM   1281 C  C     . PHE A 1 531  ? 151.203 139.697 166.146 1.00 36.12  ? 876  PHE A C     1 
ATOM   1282 O  O     . PHE A 1 531  ? 152.118 140.056 165.403 1.00 61.67  ? 876  PHE A O     1 
ATOM   1283 C  CB    . PHE A 1 531  ? 150.198 137.740 164.954 1.00 36.13  ? 876  PHE A CB    1 
ATOM   1284 C  CG    . PHE A 1 531  ? 148.982 137.077 164.378 1.00 36.99  ? 876  PHE A CG    1 
ATOM   1285 C  CD1   . PHE A 1 531  ? 148.620 137.289 163.061 1.00 40.62  ? 876  PHE A CD1   1 
ATOM   1286 C  CD2   . PHE A 1 531  ? 148.207 136.233 165.148 1.00 36.57  ? 876  PHE A CD2   1 
ATOM   1287 C  CE1   . PHE A 1 531  ? 147.507 136.678 162.529 1.00 34.13  ? 876  PHE A CE1   1 
ATOM   1288 C  CE2   . PHE A 1 531  ? 147.093 135.623 164.619 1.00 36.94  ? 876  PHE A CE2   1 
ATOM   1289 C  CZ    . PHE A 1 531  ? 146.744 135.845 163.309 1.00 35.09  ? 876  PHE A CZ    1 
ATOM   1290 N  N     . GLU A 1 532  ? 151.263 139.797 167.470 1.00 27.87  ? 877  GLU A N     1 
ATOM   1291 C  CA    . GLU A 1 532  ? 152.424 140.373 168.129 1.00 31.68  ? 877  GLU A CA    1 
ATOM   1292 C  C     . GLU A 1 532  ? 152.737 139.584 169.389 1.00 28.06  ? 877  GLU A C     1 
ATOM   1293 O  O     . GLU A 1 532  ? 151.849 138.993 170.000 1.00 42.90  ? 877  GLU A O     1 
ATOM   1294 C  CB    . GLU A 1 532  ? 152.198 141.847 168.473 1.00 40.34  ? 877  GLU A CB    1 
ATOM   1295 C  CG    . GLU A 1 532  ? 152.698 142.808 167.414 1.00 46.17  ? 877  GLU A CG    1 
ATOM   1296 C  CD    . GLU A 1 532  ? 151.983 144.140 167.454 1.00 54.33  ? 877  GLU A CD    1 
ATOM   1297 O  OE1   . GLU A 1 532  ? 151.080 144.304 168.298 1.00 49.97  ? 877  GLU A OE1   1 
ATOM   1298 O  OE2   . GLU A 1 532  ? 152.323 145.023 166.641 1.00 55.68  ? 877  GLU A OE2   1 
ATOM   1299 N  N     . SER A 1 533  ? 154.008 139.585 169.778 1.00 40.83  ? 878  SER A N     1 
ATOM   1300 C  CA    . SER A 1 533  ? 154.412 138.843 170.959 1.00 48.88  ? 878  SER A CA    1 
ATOM   1301 C  C     . SER A 1 533  ? 153.720 139.417 172.193 1.00 49.90  ? 878  SER A C     1 
ATOM   1302 O  O     . SER A 1 533  ? 153.438 140.617 172.251 1.00 54.58  ? 878  SER A O     1 
ATOM   1303 C  CB    . SER A 1 533  ? 155.927 138.893 171.136 1.00 51.30  ? 878  SER A CB    1 
ATOM   1304 O  OG    . SER A 1 533  ? 156.326 140.100 171.760 1.00 53.83  ? 878  SER A OG    1 
ATOM   1305 N  N     . PRO A 1 534  ? 153.414 138.581 173.182 1.00 56.42  ? 879  PRO A N     1 
ATOM   1306 C  CA    . PRO A 1 534  ? 152.710 139.061 174.372 1.00 58.26  ? 879  PRO A CA    1 
ATOM   1307 C  C     . PRO A 1 534  ? 153.500 140.151 175.070 1.00 61.91  ? 879  PRO A C     1 
ATOM   1308 O  O     . PRO A 1 534  ? 154.733 140.071 175.169 1.00 62.61  ? 879  PRO A O     1 
ATOM   1309 C  CB    . PRO A 1 534  ? 152.599 137.804 175.247 1.00 59.76  ? 879  PRO A CB    1 
ATOM   1310 C  CG    . PRO A 1 534  ? 152.709 136.673 174.293 1.00 58.25  ? 879  PRO A CG    1 
ATOM   1311 C  CD    . PRO A 1 534  ? 153.660 137.131 173.238 1.00 58.73  ? 879  PRO A CD    1 
ATOM   1312 N  N     . PRO A 1 535  ? 152.825 141.186 175.575 1.00 70.21  ? 880  PRO A N     1 
ATOM   1313 C  CA    . PRO A 1 535  ? 153.535 142.314 176.196 1.00 73.30  ? 880  PRO A CA    1 
ATOM   1314 C  C     . PRO A 1 535  ? 153.883 141.999 177.643 1.00 77.85  ? 880  PRO A C     1 
ATOM   1315 O  O     . PRO A 1 535  ? 153.007 141.686 178.451 1.00 79.05  ? 880  PRO A O     1 
ATOM   1316 C  CB    . PRO A 1 535  ? 152.527 143.467 176.095 1.00 74.28  ? 880  PRO A CB    1 
ATOM   1317 C  CG    . PRO A 1 535  ? 151.197 142.834 175.740 1.00 74.27  ? 880  PRO A CG    1 
ATOM   1318 C  CD    . PRO A 1 535  ? 151.366 141.350 175.638 1.00 70.85  ? 880  PRO A CD    1 
ATOM   1319 N  N     . LYS A 1 536  ? 155.170 142.085 177.967 1.00 91.60  ? 881  LYS A N     1 
ATOM   1320 C  CA    . LYS A 1 536  ? 155.655 141.821 179.320 1.00 92.40  ? 881  LYS A CA    1 
ATOM   1321 C  C     . LYS A 1 536  ? 155.606 143.127 180.103 1.00 93.42  ? 881  LYS A C     1 
ATOM   1322 O  O     . LYS A 1 536  ? 156.439 144.015 179.907 1.00 91.71  ? 881  LYS A O     1 
ATOM   1323 C  CB    . LYS A 1 536  ? 157.062 141.237 179.283 1.00 89.69  ? 881  LYS A CB    1 
ATOM   1324 C  CG    . LYS A 1 536  ? 157.375 140.303 180.439 1.00 91.39  ? 881  LYS A CG    1 
ATOM   1325 C  CD    . LYS A 1 536  ? 158.515 139.361 180.092 1.00 91.24  ? 881  LYS A CD    1 
ATOM   1326 C  CE    . LYS A 1 536  ? 158.601 138.213 181.083 1.00 91.45  ? 881  LYS A CE    1 
ATOM   1327 N  NZ    . LYS A 1 536  ? 159.591 137.185 180.660 1.00 90.48  ? 881  LYS A NZ    1 
ATOM   1328 N  N     . THR A 1 537  ? 154.627 143.244 180.994 1.00 101.53 ? 882  THR A N     1 
ATOM   1329 C  CA    . THR A 1 537  ? 154.451 144.456 181.786 1.00 102.12 ? 882  THR A CA    1 
ATOM   1330 C  C     . THR A 1 537  ? 154.194 144.121 183.251 1.00 100.94 ? 882  THR A C     1 
ATOM   1331 O  O     . THR A 1 537  ? 154.885 144.615 184.142 1.00 100.16 ? 882  THR A O     1 
ATOM   1332 C  CB    . THR A 1 537  ? 153.290 145.314 181.251 1.00 100.78 ? 882  THR A CB    1 
ATOM   1333 O  OG1   . THR A 1 537  ? 153.559 145.696 179.896 1.00 99.93  ? 882  THR A OG1   1 
ATOM   1334 C  CG2   . THR A 1 537  ? 153.113 146.564 182.100 1.00 98.38  ? 882  THR A CG2   1 
ATOM   1335 N  N     . PHE A 1 545  ? 146.746 142.392 192.811 1.00 132.57 ? 890  PHE A N     1 
ATOM   1336 C  CA    . PHE A 1 545  ? 146.083 143.676 193.010 1.00 131.74 ? 890  PHE A CA    1 
ATOM   1337 C  C     . PHE A 1 545  ? 145.240 144.055 191.795 1.00 131.47 ? 890  PHE A C     1 
ATOM   1338 O  O     . PHE A 1 545  ? 145.095 145.235 191.474 1.00 131.35 ? 890  PHE A O     1 
ATOM   1339 C  CB    . PHE A 1 545  ? 147.110 144.775 193.311 1.00 131.93 ? 890  PHE A CB    1 
ATOM   1340 C  CG    . PHE A 1 545  ? 148.217 144.877 192.295 1.00 132.37 ? 890  PHE A CG    1 
ATOM   1341 C  CD1   . PHE A 1 545  ? 149.337 144.064 192.384 1.00 131.24 ? 890  PHE A CD1   1 
ATOM   1342 C  CD2   . PHE A 1 545  ? 148.144 145.792 191.258 1.00 131.55 ? 890  PHE A CD2   1 
ATOM   1343 C  CE1   . PHE A 1 545  ? 150.356 144.158 191.456 1.00 131.21 ? 890  PHE A CE1   1 
ATOM   1344 C  CE2   . PHE A 1 545  ? 149.160 145.890 190.326 1.00 130.85 ? 890  PHE A CE2   1 
ATOM   1345 C  CZ    . PHE A 1 545  ? 150.268 145.071 190.426 1.00 131.38 ? 890  PHE A CZ    1 
ATOM   1346 N  N     . LYS A 1 546  ? 144.684 143.038 191.134 1.00 123.84 ? 891  LYS A N     1 
ATOM   1347 C  CA    . LYS A 1 546  ? 143.830 143.211 189.958 1.00 123.61 ? 891  LYS A CA    1 
ATOM   1348 C  C     . LYS A 1 546  ? 144.567 143.969 188.851 1.00 123.55 ? 891  LYS A C     1 
ATOM   1349 O  O     . LYS A 1 546  ? 144.173 145.058 188.429 1.00 122.98 ? 891  LYS A O     1 
ATOM   1350 C  CB    . LYS A 1 546  ? 142.517 143.909 190.331 1.00 124.86 ? 891  LYS A CB    1 
ATOM   1351 C  CG    . LYS A 1 546  ? 141.402 143.716 189.314 1.00 124.95 ? 891  LYS A CG    1 
ATOM   1352 C  CD    . LYS A 1 546  ? 140.553 144.967 189.177 1.00 123.58 ? 891  LYS A CD    1 
ATOM   1353 C  CE    . LYS A 1 546  ? 139.774 144.954 187.874 1.00 121.37 ? 891  LYS A CE    1 
ATOM   1354 N  NZ    . LYS A 1 546  ? 140.629 144.539 186.730 1.00 120.52 ? 891  LYS A NZ    1 
ATOM   1355 N  N     . PHE A 1 547  ? 145.658 143.367 188.387 1.00 125.54 ? 892  PHE A N     1 
ATOM   1356 C  CA    . PHE A 1 547  ? 146.457 143.916 187.298 1.00 126.57 ? 892  PHE A CA    1 
ATOM   1357 C  C     . PHE A 1 547  ? 146.061 143.212 186.007 1.00 126.89 ? 892  PHE A C     1 
ATOM   1358 O  O     . PHE A 1 547  ? 146.399 142.042 185.800 1.00 127.41 ? 892  PHE A O     1 
ATOM   1359 C  CB    . PHE A 1 547  ? 147.950 143.754 187.574 1.00 125.83 ? 892  PHE A CB    1 
ATOM   1360 C  CG    . PHE A 1 547  ? 148.809 143.904 186.351 1.00 127.01 ? 892  PHE A CG    1 
ATOM   1361 C  CD1   . PHE A 1 547  ? 148.836 145.098 185.649 1.00 127.01 ? 892  PHE A CD1   1 
ATOM   1362 C  CD2   . PHE A 1 547  ? 149.586 142.850 185.899 1.00 125.77 ? 892  PHE A CD2   1 
ATOM   1363 C  CE1   . PHE A 1 547  ? 149.622 145.239 184.522 1.00 125.13 ? 892  PHE A CE1   1 
ATOM   1364 C  CE2   . PHE A 1 547  ? 150.375 142.985 184.773 1.00 124.78 ? 892  PHE A CE2   1 
ATOM   1365 C  CZ    . PHE A 1 547  ? 150.393 144.181 184.083 1.00 124.45 ? 892  PHE A CZ    1 
ATOM   1366 N  N     . CYS A 1 548  ? 145.346 143.923 185.142 1.00 115.81 ? 893  CYS A N     1 
ATOM   1367 C  CA    . CYS A 1 548  ? 144.935 143.410 183.844 1.00 114.40 ? 893  CYS A CA    1 
ATOM   1368 C  C     . CYS A 1 548  ? 145.640 144.199 182.751 1.00 112.63 ? 893  CYS A C     1 
ATOM   1369 O  O     . CYS A 1 548  ? 145.580 145.433 182.733 1.00 115.65 ? 893  CYS A O     1 
ATOM   1370 C  CB    . CYS A 1 548  ? 143.418 143.500 183.673 1.00 114.20 ? 893  CYS A CB    1 
ATOM   1371 S  SG    . CYS A 1 548  ? 142.865 143.452 181.959 1.00 113.58 ? 893  CYS A SG    1 
ATOM   1372 N  N     . VAL A 1 549  ? 146.311 143.484 181.846 1.00 111.00 ? 894  VAL A N     1 
ATOM   1373 C  CA    . VAL A 1 549  ? 147.021 144.142 180.753 1.00 112.74 ? 894  VAL A CA    1 
ATOM   1374 C  C     . VAL A 1 549  ? 146.037 144.853 179.832 1.00 111.44 ? 894  VAL A C     1 
ATOM   1375 O  O     . VAL A 1 549  ? 146.282 145.982 179.387 1.00 110.62 ? 894  VAL A O     1 
ATOM   1376 C  CB    . VAL A 1 549  ? 147.884 143.119 179.991 1.00 114.44 ? 894  VAL A CB    1 
ATOM   1377 C  CG1   . VAL A 1 549  ? 148.209 143.619 178.594 1.00 112.47 ? 894  VAL A CG1   1 
ATOM   1378 C  CG2   . VAL A 1 549  ? 149.158 142.821 180.765 1.00 113.23 ? 894  VAL A CG2   1 
ATOM   1379 N  N     . SER A 1 550  ? 144.906 144.207 179.539 1.00 109.96 ? 895  SER A N     1 
ATOM   1380 C  CA    . SER A 1 550  ? 143.912 144.812 178.660 1.00 111.78 ? 895  SER A CA    1 
ATOM   1381 C  C     . SER A 1 550  ? 143.353 146.098 179.254 1.00 113.98 ? 895  SER A C     1 
ATOM   1382 O  O     . SER A 1 550  ? 143.168 147.089 178.540 1.00 113.44 ? 895  SER A O     1 
ATOM   1383 C  CB    . SER A 1 550  ? 142.783 143.821 178.381 1.00 110.93 ? 895  SER A CB    1 
ATOM   1384 O  OG    . SER A 1 550  ? 141.602 144.494 177.981 1.00 112.53 ? 895  SER A OG    1 
ATOM   1385 N  N     . CYS A 1 551  ? 143.070 146.098 180.559 1.00 120.59 ? 896  CYS A N     1 
ATOM   1386 C  CA    . CYS A 1 551  ? 142.540 147.299 181.197 1.00 117.44 ? 896  CYS A CA    1 
ATOM   1387 C  C     . CYS A 1 551  ? 143.530 148.453 181.108 1.00 118.99 ? 896  CYS A C     1 
ATOM   1388 O  O     . CYS A 1 551  ? 143.147 149.585 180.790 1.00 117.97 ? 896  CYS A O     1 
ATOM   1389 C  CB    . CYS A 1 551  ? 142.188 147.007 182.655 1.00 116.91 ? 896  CYS A CB    1 
ATOM   1390 S  SG    . CYS A 1 551  ? 140.514 146.382 182.911 1.00 121.64 ? 896  CYS A SG    1 
ATOM   1391 N  N     . ALA A 1 552  ? 144.809 148.183 181.377 1.00 122.86 ? 897  ALA A N     1 
ATOM   1392 C  CA    . ALA A 1 552  ? 145.821 149.232 181.296 1.00 121.45 ? 897  ALA A CA    1 
ATOM   1393 C  C     . ALA A 1 552  ? 145.977 149.745 179.870 1.00 120.62 ? 897  ALA A C     1 
ATOM   1394 O  O     . ALA A 1 552  ? 146.077 150.958 179.649 1.00 120.20 ? 897  ALA A O     1 
ATOM   1395 C  CB    . ALA A 1 552  ? 147.156 148.716 181.831 1.00 118.44 ? 897  ALA A CB    1 
ATOM   1396 N  N     . ARG A 1 553  ? 145.997 148.838 178.889 1.00 110.90 ? 898  ARG A N     1 
ATOM   1397 C  CA    . ARG A 1 553  ? 146.136 149.260 177.498 1.00 111.90 ? 898  ARG A CA    1 
ATOM   1398 C  C     . ARG A 1 553  ? 144.949 150.109 177.059 1.00 112.80 ? 898  ARG A C     1 
ATOM   1399 O  O     . ARG A 1 553  ? 145.120 151.137 176.391 1.00 112.14 ? 898  ARG A O     1 
ATOM   1400 C  CB    . ARG A 1 553  ? 146.287 148.037 176.594 1.00 112.05 ? 898  ARG A CB    1 
ATOM   1401 C  CG    . ARG A 1 553  ? 147.638 147.348 176.702 1.00 111.30 ? 898  ARG A CG    1 
ATOM   1402 C  CD    . ARG A 1 553  ? 147.648 146.027 175.950 1.00 110.52 ? 898  ARG A CD    1 
ATOM   1403 N  NE    . ARG A 1 553  ? 147.796 146.212 174.512 1.00 109.40 ? 898  ARG A NE    1 
ATOM   1404 C  CZ    . ARG A 1 553  ? 148.959 146.224 173.876 1.00 110.50 ? 898  ARG A CZ    1 
ATOM   1405 N  NH1   . ARG A 1 553  ? 150.100 146.050 174.522 1.00 110.48 ? 898  ARG A NH1   1 
ATOM   1406 N  NH2   . ARG A 1 553  ? 148.977 146.412 172.560 1.00 111.43 ? 898  ARG A NH2   1 
ATOM   1407 N  N     . LEU A 1 554  ? 143.735 149.704 177.436 1.00 122.41 ? 899  LEU A N     1 
ATOM   1408 C  CA    . LEU A 1 554  ? 142.558 150.473 177.055 1.00 122.86 ? 899  LEU A CA    1 
ATOM   1409 C  C     . LEU A 1 554  ? 142.508 151.822 177.763 1.00 124.53 ? 899  LEU A C     1 
ATOM   1410 O  O     . LEU A 1 554  ? 142.086 152.814 177.162 1.00 125.52 ? 899  LEU A O     1 
ATOM   1411 C  CB    . LEU A 1 554  ? 141.292 149.666 177.336 1.00 123.38 ? 899  LEU A CB    1 
ATOM   1412 C  CG    . LEU A 1 554  ? 141.090 148.421 176.469 1.00 124.36 ? 899  LEU A CG    1 
ATOM   1413 C  CD1   . LEU A 1 554  ? 139.852 147.654 176.908 1.00 122.89 ? 899  LEU A CD1   1 
ATOM   1414 C  CD2   . LEU A 1 554  ? 141.004 148.795 174.998 1.00 123.35 ? 899  LEU A CD2   1 
ATOM   1415 N  N     . ALA A 1 555  ? 142.931 151.886 179.030 1.00 125.48 ? 900  ALA A N     1 
ATOM   1416 C  CA    . ALA A 1 555  ? 142.999 153.174 179.715 1.00 124.43 ? 900  ALA A CA    1 
ATOM   1417 C  C     . ALA A 1 555  ? 144.023 154.089 179.057 1.00 125.35 ? 900  ALA A C     1 
ATOM   1418 O  O     . ALA A 1 555  ? 143.798 155.300 178.925 1.00 124.31 ? 900  ALA A O     1 
ATOM   1419 C  CB    . ALA A 1 555  ? 143.330 152.969 181.192 1.00 122.75 ? 900  ALA A CB    1 
ATOM   1420 N  N     . GLU A 1 556  ? 145.158 153.524 178.637 1.00 127.57 ? 901  GLU A N     1 
ATOM   1421 C  CA    . GLU A 1 556  ? 146.136 154.302 177.888 1.00 128.63 ? 901  GLU A CA    1 
ATOM   1422 C  C     . GLU A 1 556  ? 145.539 154.818 176.586 1.00 127.47 ? 901  GLU A C     1 
ATOM   1423 O  O     . GLU A 1 556  ? 145.800 155.955 176.185 1.00 125.42 ? 901  GLU A O     1 
ATOM   1424 C  CB    . GLU A 1 556  ? 147.380 153.457 177.613 1.00 128.16 ? 901  GLU A CB    1 
ATOM   1425 C  CG    . GLU A 1 556  ? 148.387 153.446 178.752 1.00 128.14 ? 901  GLU A CG    1 
ATOM   1426 C  CD    . GLU A 1 556  ? 148.831 154.840 179.153 1.00 129.48 ? 901  GLU A CD    1 
ATOM   1427 O  OE1   . GLU A 1 556  ? 149.747 155.383 178.502 1.00 129.35 ? 901  GLU A OE1   1 
ATOM   1428 O  OE2   . GLU A 1 556  ? 148.266 155.390 180.122 1.00 127.93 ? 901  GLU A OE2   1 
ATOM   1429 N  N     . MET A 1 557  ? 144.729 153.996 175.914 1.00 126.10 ? 902  MET A N     1 
ATOM   1430 C  CA    . MET A 1 557  ? 144.059 154.449 174.696 1.00 125.07 ? 902  MET A CA    1 
ATOM   1431 C  C     . MET A 1 557  ? 143.095 155.598 174.981 1.00 123.14 ? 902  MET A C     1 
ATOM   1432 O  O     . MET A 1 557  ? 143.055 156.588 174.235 1.00 122.78 ? 902  MET A O     1 
ATOM   1433 C  CB    . MET A 1 557  ? 143.321 153.282 174.041 1.00 125.76 ? 902  MET A CB    1 
ATOM   1434 C  CG    . MET A 1 557  ? 143.240 153.367 172.526 1.00 127.40 ? 902  MET A CG    1 
ATOM   1435 S  SD    . MET A 1 557  ? 142.007 152.246 171.837 1.00 133.78 ? 902  MET A SD    1 
ATOM   1436 C  CE    . MET A 1 557  ? 142.930 150.711 171.793 1.00 126.51 ? 902  MET A CE    1 
ATOM   1437 N  N     . ARG A 1 558  ? 142.304 155.482 176.054 1.00 124.30 ? 903  ARG A N     1 
ATOM   1438 C  CA    . ARG A 1 558  ? 141.370 156.552 176.395 1.00 126.64 ? 903  ARG A CA    1 
ATOM   1439 C  C     . ARG A 1 558  ? 142.107 157.848 176.698 1.00 127.29 ? 903  ARG A C     1 
ATOM   1440 O  O     . ARG A 1 558  ? 141.663 158.930 176.298 1.00 124.97 ? 903  ARG A O     1 
ATOM   1441 C  CB    . ARG A 1 558  ? 140.491 156.170 177.589 1.00 125.54 ? 903  ARG A CB    1 
ATOM   1442 C  CG    . ARG A 1 558  ? 139.847 154.798 177.560 1.00 125.82 ? 903  ARG A CG    1 
ATOM   1443 C  CD    . ARG A 1 558  ? 139.346 154.445 178.956 1.00 125.54 ? 903  ARG A CD    1 
ATOM   1444 N  NE    . ARG A 1 558  ? 139.611 153.065 179.343 1.00 126.93 ? 903  ARG A NE    1 
ATOM   1445 C  CZ    . ARG A 1 558  ? 138.884 152.025 178.958 1.00 126.61 ? 903  ARG A CZ    1 
ATOM   1446 N  NH1   . ARG A 1 558  ? 137.859 152.165 178.132 1.00 126.66 ? 903  ARG A NH1   1 
ATOM   1447 N  NH2   . ARG A 1 558  ? 139.186 150.815 179.419 1.00 125.38 ? 903  ARG A NH2   1 
ATOM   1448 N  N     . GLN A 1 559  ? 143.224 157.767 177.416 1.00 126.67 ? 904  GLN A N     1 
ATOM   1449 C  CA    . GLN A 1 559  ? 144.002 158.974 177.665 1.00 125.52 ? 904  GLN A CA    1 
ATOM   1450 C  C     . GLN A 1 559  ? 144.734 159.459 176.420 1.00 125.21 ? 904  GLN A C     1 
ATOM   1451 O  O     . GLN A 1 559  ? 145.096 160.638 176.348 1.00 124.10 ? 904  GLN A O     1 
ATOM   1452 C  CB    . GLN A 1 559  ? 144.997 158.737 178.803 1.00 123.73 ? 904  GLN A CB    1 
ATOM   1453 C  CG    . GLN A 1 559  ? 144.435 158.724 180.245 1.00 124.26 ? 904  GLN A CG    1 
ATOM   1454 C  CD    . GLN A 1 559  ? 143.367 159.778 180.558 1.00 124.51 ? 904  GLN A CD    1 
ATOM   1455 O  OE1   . GLN A 1 559  ? 142.381 159.950 179.839 1.00 123.74 ? 904  GLN A OE1   1 
ATOM   1456 N  NE2   . GLN A 1 559  ? 143.575 160.492 181.656 1.00 124.57 ? 904  GLN A NE2   1 
ATOM   1457 N  N     . LYS A 1 560  ? 144.961 158.575 175.447 1.00 120.92 ? 905  LYS A N     1 
ATOM   1458 C  CA    . LYS A 1 560  ? 145.591 158.981 174.196 1.00 120.85 ? 905  LYS A CA    1 
ATOM   1459 C  C     . LYS A 1 560  ? 144.636 159.791 173.330 1.00 119.82 ? 905  LYS A C     1 
ATOM   1460 O  O     . LYS A 1 560  ? 145.031 160.807 172.746 1.00 117.97 ? 905  LYS A O     1 
ATOM   1461 C  CB    . LYS A 1 560  ? 146.080 157.746 173.439 1.00 118.82 ? 905  LYS A CB    1 
ATOM   1462 C  CG    . LYS A 1 560  ? 147.523 157.363 173.722 1.00 118.07 ? 905  LYS A CG    1 
ATOM   1463 C  CD    . LYS A 1 560  ? 148.436 157.731 172.564 1.00 117.98 ? 905  LYS A CD    1 
ATOM   1464 C  CE    . LYS A 1 560  ? 149.898 157.564 172.942 1.00 117.76 ? 905  LYS A CE    1 
ATOM   1465 N  NZ    . LYS A 1 560  ? 150.792 157.709 171.763 1.00 117.04 ? 905  LYS A NZ    1 
ATOM   1466 N  N     . GLU A 1 561  ? 143.376 159.359 173.230 1.00 117.84 ? 906  GLU A N     1 
ATOM   1467 C  CA    . GLU A 1 561  ? 142.454 160.016 172.308 1.00 116.82 ? 906  GLU A CA    1 
ATOM   1468 C  C     . GLU A 1 561  ? 142.098 161.435 172.740 1.00 115.84 ? 906  GLU A C     1 
ATOM   1469 O  O     . GLU A 1 561  ? 141.922 162.308 171.882 1.00 113.86 ? 906  GLU A O     1 
ATOM   1470 C  CB    . GLU A 1 561  ? 141.178 159.184 172.142 1.00 117.23 ? 906  GLU A CB    1 
ATOM   1471 C  CG    . GLU A 1 561  ? 140.490 158.802 173.440 1.00 118.98 ? 906  GLU A CG    1 
ATOM   1472 C  CD    . GLU A 1 561  ? 139.506 159.853 173.914 1.00 118.37 ? 906  GLU A CD    1 
ATOM   1473 O  OE1   . GLU A 1 561  ? 139.083 160.689 173.088 1.00 118.48 ? 906  GLU A OE1   1 
ATOM   1474 O  OE2   . GLU A 1 561  ? 139.159 159.849 175.114 1.00 116.35 ? 906  GLU A OE2   1 
ATOM   1475 N  N     . ILE A 1 562  ? 141.984 161.690 174.036 1.00 108.69 ? 907  ILE A N     1 
ATOM   1476 C  CA    . ILE A 1 562  ? 141.513 163.003 174.495 1.00 109.68 ? 907  ILE A CA    1 
ATOM   1477 C  C     . ILE A 1 562  ? 142.659 164.008 174.425 1.00 109.00 ? 907  ILE A C     1 
ATOM   1478 O  O     . ILE A 1 562  ? 143.753 163.736 174.950 1.00 109.30 ? 907  ILE A O     1 
ATOM   1479 C  CB    . ILE A 1 562  ? 140.949 162.904 175.913 1.00 107.73 ? 907  ILE A CB    1 
ATOM   1480 C  CG1   . ILE A 1 562  ? 140.736 164.301 176.501 1.00 106.76 ? 907  ILE A CG1   1 
ATOM   1481 C  CG2   . ILE A 1 562  ? 141.866 162.080 176.806 1.00 106.39 ? 907  ILE A CG2   1 
ATOM   1482 C  CD1   . ILE A 1 562  ? 139.790 164.330 177.679 1.00 106.17 ? 907  ILE A CD1   1 
ATOM   1483 N  N     . PRO A 1 563  ? 142.471 165.165 173.786 1.00 92.95  ? 908  PRO A N     1 
ATOM   1484 C  CA    . PRO A 1 563  ? 143.512 166.201 173.804 1.00 89.91  ? 908  PRO A CA    1 
ATOM   1485 C  C     . PRO A 1 563  ? 143.508 166.933 175.139 1.00 90.15  ? 908  PRO A C     1 
ATOM   1486 O  O     . PRO A 1 563  ? 142.459 167.361 175.623 1.00 91.56  ? 908  PRO A O     1 
ATOM   1487 C  CB    . PRO A 1 563  ? 143.109 167.130 172.655 1.00 88.96  ? 908  PRO A CB    1 
ATOM   1488 C  CG    . PRO A 1 563  ? 141.627 166.988 172.580 1.00 88.55  ? 908  PRO A CG    1 
ATOM   1489 C  CD    . PRO A 1 563  ? 141.305 165.567 172.980 1.00 91.29  ? 908  PRO A CD    1 
ATOM   1490 N  N     . ARG A 1 564  ? 144.688 167.077 175.732 1.00 88.25  ? 909  ARG A N     1 
ATOM   1491 C  CA    . ARG A 1 564  ? 144.827 167.700 177.040 1.00 87.79  ? 909  ARG A CA    1 
ATOM   1492 C  C     . ARG A 1 564  ? 145.819 168.850 176.962 1.00 87.94  ? 909  ARG A C     1 
ATOM   1493 O  O     . ARG A 1 564  ? 146.818 168.774 176.242 1.00 91.01  ? 909  ARG A O     1 
ATOM   1494 C  CB    . ARG A 1 564  ? 145.265 166.675 178.093 1.00 90.43  ? 909  ARG A CB    1 
ATOM   1495 C  CG    . ARG A 1 564  ? 146.519 165.902 177.731 1.00 91.06  ? 909  ARG A CG    1 
ATOM   1496 C  CD    . ARG A 1 564  ? 146.876 164.888 178.810 1.00 89.64  ? 909  ARG A CD    1 
ATOM   1497 N  NE    . ARG A 1 564  ? 148.274 164.472 178.763 1.00 91.27  ? 909  ARG A NE    1 
ATOM   1498 C  CZ    . ARG A 1 564  ? 149.316 165.280 178.912 1.00 90.78  ? 909  ARG A CZ    1 
ATOM   1499 N  NH1   . ARG A 1 564  ? 149.165 166.567 179.179 1.00 90.04  ? 909  ARG A NH1   1 
ATOM   1500 N  NH2   . ARG A 1 564  ? 150.544 164.779 178.808 1.00 91.94  ? 909  ARG A NH2   1 
ATOM   1501 N  N     . VAL A 1 565  ? 145.551 169.910 177.717 1.00 84.97  ? 910  VAL A N     1 
ATOM   1502 C  CA    . VAL A 1 565  ? 146.275 171.166 177.582 1.00 87.46  ? 910  VAL A CA    1 
ATOM   1503 C  C     . VAL A 1 565  ? 146.982 171.478 178.894 1.00 88.88  ? 910  VAL A C     1 
ATOM   1504 O  O     . VAL A 1 565  ? 146.505 171.106 179.972 1.00 90.69  ? 910  VAL A O     1 
ATOM   1505 C  CB    . VAL A 1 565  ? 145.324 172.309 177.179 1.00 85.78  ? 910  VAL A CB    1 
ATOM   1506 C  CG1   . VAL A 1 565  ? 146.111 173.491 176.689 1.00 87.48  ? 910  VAL A CG1   1 
ATOM   1507 C  CG2   . VAL A 1 565  ? 144.362 171.832 176.118 1.00 86.83  ? 910  VAL A CG2   1 
ATOM   1508 N  N     . LEU A 1 566  ? 148.120 172.164 178.796 1.00 91.83  ? 911  LEU A N     1 
ATOM   1509 C  CA    . LEU A 1 566  ? 148.986 172.435 179.934 1.00 91.83  ? 911  LEU A CA    1 
ATOM   1510 C  C     . LEU A 1 566  ? 149.737 173.740 179.695 1.00 95.10  ? 911  LEU A C     1 
ATOM   1511 O  O     . LEU A 1 566  ? 149.634 174.354 178.628 1.00 98.59  ? 911  LEU A O     1 
ATOM   1512 C  CB    . LEU A 1 566  ? 149.936 171.254 180.164 1.00 93.10  ? 911  LEU A CB    1 
ATOM   1513 C  CG    . LEU A 1 566  ? 150.779 170.829 178.957 1.00 90.83  ? 911  LEU A CG    1 
ATOM   1514 C  CD1   . LEU A 1 566  ? 152.149 171.479 178.955 1.00 90.04  ? 911  LEU A CD1   1 
ATOM   1515 C  CD2   . LEU A 1 566  ? 150.907 169.316 178.898 1.00 92.36  ? 911  LEU A CD2   1 
ATOM   1516 N  N     . GLU A 1 567  ? 150.500 174.165 180.705 1.00 102.61 ? 912  GLU A N     1 
ATOM   1517 C  CA    . GLU A 1 567  ? 151.364 175.347 180.632 1.00 102.31 ? 912  GLU A CA    1 
ATOM   1518 C  C     . GLU A 1 567  ? 150.561 176.616 180.321 1.00 100.80 ? 912  GLU A C     1 
ATOM   1519 O  O     . GLU A 1 567  ? 150.649 177.201 179.241 1.00 102.18 ? 912  GLU A O     1 
ATOM   1520 C  CB    . GLU A 1 567  ? 152.493 175.146 179.616 1.00 103.07 ? 912  GLU A CB    1 
ATOM   1521 C  CG    . GLU A 1 567  ? 153.691 174.396 180.167 1.00 102.98 ? 912  GLU A CG    1 
ATOM   1522 C  CD    . GLU A 1 567  ? 154.963 175.219 180.114 1.00 105.74 ? 912  GLU A CD    1 
ATOM   1523 O  OE1   . GLU A 1 567  ? 154.865 176.460 180.007 1.00 104.79 ? 912  GLU A OE1   1 
ATOM   1524 O  OE2   . GLU A 1 567  ? 156.060 174.628 180.181 1.00 106.82 ? 912  GLU A OE2   1 
ATOM   1525 N  N     . GLN A 1 568  ? 149.753 177.012 181.304 1.00 102.72 ? 913  GLN A N     1 
ATOM   1526 C  CA    . GLN A 1 568  ? 149.068 178.298 181.241 1.00 103.95 ? 913  GLN A CA    1 
ATOM   1527 C  C     . GLN A 1 568  ? 150.069 179.428 181.046 1.00 107.31 ? 913  GLN A C     1 
ATOM   1528 O  O     . GLN A 1 568  ? 151.100 179.482 181.720 1.00 109.90 ? 913  GLN A O     1 
ATOM   1529 C  CB    . GLN A 1 568  ? 148.266 178.524 182.523 1.00 105.89 ? 913  GLN A CB    1 
ATOM   1530 C  CG    . GLN A 1 568  ? 147.422 179.784 182.518 1.00 106.02 ? 913  GLN A CG    1 
ATOM   1531 C  CD    . GLN A 1 568  ? 145.943 179.485 182.399 1.00 108.90 ? 913  GLN A CD    1 
ATOM   1532 O  OE1   . GLN A 1 568  ? 145.507 178.356 182.626 1.00 107.58 ? 913  GLN A OE1   1 
ATOM   1533 N  NE2   . GLN A 1 568  ? 145.159 180.498 182.053 1.00 109.29 ? 913  GLN A NE2   1 
ATOM   1534 N  N     . LEU A 1 569  ? 149.764 180.333 180.116 1.00 115.86 ? 914  LEU A N     1 
ATOM   1535 C  CA    . LEU A 1 569  ? 150.651 181.440 179.789 1.00 115.11 ? 914  LEU A CA    1 
ATOM   1536 C  C     . LEU A 1 569  ? 150.110 182.780 180.259 1.00 115.70 ? 914  LEU A C     1 
ATOM   1537 O  O     . LEU A 1 569  ? 150.832 183.556 180.893 1.00 115.80 ? 914  LEU A O     1 
ATOM   1538 C  CB    . LEU A 1 569  ? 150.890 181.487 178.274 1.00 113.21 ? 914  LEU A CB    1 
ATOM   1539 C  CG    . LEU A 1 569  ? 151.656 182.697 177.737 1.00 113.90 ? 914  LEU A CG    1 
ATOM   1540 C  CD1   . LEU A 1 569  ? 153.100 182.663 178.203 1.00 113.96 ? 914  LEU A CD1   1 
ATOM   1541 C  CD2   . LEU A 1 569  ? 151.582 182.747 176.219 1.00 114.59 ? 914  LEU A CD2   1 
ATOM   1542 N  N     . GLU A 1 570  ? 148.852 183.080 179.946 1.00 121.83 ? 915  GLU A N     1 
ATOM   1543 C  CA    . GLU A 1 570  ? 148.237 184.339 180.339 1.00 121.18 ? 915  GLU A CA    1 
ATOM   1544 C  C     . GLU A 1 570  ? 146.731 184.152 180.408 1.00 121.35 ? 915  GLU A C     1 
ATOM   1545 O  O     . GLU A 1 570  ? 146.154 183.431 179.592 1.00 121.20 ? 915  GLU A O     1 
ATOM   1546 C  CB    . GLU A 1 570  ? 148.582 185.470 179.357 1.00 120.11 ? 915  GLU A CB    1 
ATOM   1547 C  CG    . GLU A 1 570  ? 147.944 186.872 179.601 1.00 121.13 ? 915  GLU A CG    1 
ATOM   1548 C  CD    . GLU A 1 570  ? 147.812 187.329 181.062 1.00 120.66 ? 915  GLU A CD    1 
ATOM   1549 O  OE1   . GLU A 1 570  ? 148.176 186.613 182.014 1.00 118.86 ? 915  GLU A OE1   1 
ATOM   1550 O  OE2   . GLU A 1 570  ? 147.317 188.461 181.256 1.00 120.38 ? 915  GLU A OE2   1 
ATOM   1551 N  N     . ASP A 1 571  ? 146.102 184.806 181.379 1.00 121.47 ? 916  ASP A N     1 
ATOM   1552 C  CA    . ASP A 1 571  ? 144.656 184.768 181.549 1.00 122.49 ? 916  ASP A CA    1 
ATOM   1553 C  C     . ASP A 1 571  ? 144.081 186.076 181.025 1.00 124.66 ? 916  ASP A C     1 
ATOM   1554 O  O     . ASP A 1 571  ? 144.475 187.155 181.479 1.00 124.02 ? 916  ASP A O     1 
ATOM   1555 C  CB    . ASP A 1 571  ? 144.283 184.552 183.018 1.00 121.31 ? 916  ASP A CB    1 
ATOM   1556 C  CG    . ASP A 1 571  ? 142.779 184.472 183.245 1.00 121.67 ? 916  ASP A CG    1 
ATOM   1557 O  OD1   . ASP A 1 571  ? 142.071 185.470 182.996 1.00 121.89 ? 916  ASP A OD1   1 
ATOM   1558 O  OD2   . ASP A 1 571  ? 142.303 183.403 183.679 1.00 121.54 ? 916  ASP A OD2   1 
ATOM   1559 N  N     . LEU A 1 572  ? 143.158 185.981 180.074 1.00 124.59 ? 917  LEU A N     1 
ATOM   1560 C  CA    . LEU A 1 572  ? 142.517 187.146 179.484 1.00 121.94 ? 917  LEU A CA    1 
ATOM   1561 C  C     . LEU A 1 572  ? 141.068 187.232 179.954 1.00 122.16 ? 917  LEU A C     1 
ATOM   1562 O  O     . LEU A 1 572  ? 140.556 186.349 180.648 1.00 122.46 ? 917  LEU A O     1 
ATOM   1563 C  CB    . LEU A 1 572  ? 142.607 187.095 177.958 1.00 120.92 ? 917  LEU A CB    1 
ATOM   1564 C  CG    . LEU A 1 572  ? 143.074 188.379 177.273 1.00 121.93 ? 917  LEU A CG    1 
ATOM   1565 C  CD1   . LEU A 1 572  ? 144.408 188.818 177.848 1.00 120.10 ? 917  LEU A CD1   1 
ATOM   1566 C  CD2   . LEU A 1 572  ? 143.178 188.181 175.772 1.00 122.26 ? 917  LEU A CD2   1 
ATOM   1567 N  N     . ASP A 1 573  ? 140.405 188.324 179.566 1.00 123.18 ? 918  ASP A N     1 
ATOM   1568 C  CA    . ASP A 1 573  ? 139.048 188.576 180.041 1.00 122.77 ? 918  ASP A CA    1 
ATOM   1569 C  C     . ASP A 1 573  ? 138.064 187.531 179.527 1.00 123.50 ? 918  ASP A C     1 
ATOM   1570 O  O     . ASP A 1 573  ? 137.214 187.049 180.284 1.00 123.14 ? 918  ASP A O     1 
ATOM   1571 C  CB    . ASP A 1 573  ? 138.604 189.978 179.627 1.00 122.57 ? 918  ASP A CB    1 
ATOM   1572 C  CG    . ASP A 1 573  ? 139.142 190.381 178.272 1.00 124.08 ? 918  ASP A CG    1 
ATOM   1573 O  OD1   . ASP A 1 573  ? 139.108 191.587 177.949 1.00 122.49 ? 918  ASP A OD1   1 
ATOM   1574 O  OD2   . ASP A 1 573  ? 139.604 189.489 177.529 1.00 124.96 ? 918  ASP A OD2   1 
ATOM   1575 N  N     . SER A 1 574  ? 138.162 187.165 178.250 1.00 119.75 ? 919  SER A N     1 
ATOM   1576 C  CA    . SER A 1 574  ? 137.196 186.271 177.625 1.00 118.87 ? 919  SER A CA    1 
ATOM   1577 C  C     . SER A 1 574  ? 137.777 184.914 177.253 1.00 119.14 ? 919  SER A C     1 
ATOM   1578 O  O     . SER A 1 574  ? 137.031 184.044 176.792 1.00 119.15 ? 919  SER A O     1 
ATOM   1579 C  CB    . SER A 1 574  ? 136.600 186.930 176.376 1.00 118.22 ? 919  SER A CB    1 
ATOM   1580 O  OG    . SER A 1 574  ? 135.902 185.983 175.587 1.00 120.34 ? 919  SER A OG    1 
ATOM   1581 N  N     . ARG A 1 575  ? 139.077 184.707 177.437 1.00 115.47 ? 920  ARG A N     1 
ATOM   1582 C  CA    . ARG A 1 575  ? 139.703 183.441 177.082 1.00 115.05 ? 920  ARG A CA    1 
ATOM   1583 C  C     . ARG A 1 575  ? 140.978 183.284 177.896 1.00 113.41 ? 920  ARG A C     1 
ATOM   1584 O  O     . ARG A 1 575  ? 141.457 184.228 178.527 1.00 112.92 ? 920  ARG A O     1 
ATOM   1585 C  CB    . ARG A 1 575  ? 139.993 183.362 175.581 1.00 114.84 ? 920  ARG A CB    1 
ATOM   1586 C  CG    . ARG A 1 575  ? 140.737 184.563 175.027 1.00 114.54 ? 920  ARG A CG    1 
ATOM   1587 C  CD    . ARG A 1 575  ? 140.635 184.620 173.514 1.00 114.32 ? 920  ARG A CD    1 
ATOM   1588 N  NE    . ARG A 1 575  ? 141.846 185.157 172.908 1.00 113.94 ? 920  ARG A NE    1 
ATOM   1589 C  CZ    . ARG A 1 575  ? 141.987 186.412 172.505 1.00 114.80 ? 920  ARG A CZ    1 
ATOM   1590 N  NH1   . ARG A 1 575  ? 141.005 187.290 172.626 1.00 114.91 ? 920  ARG A NH1   1 
ATOM   1591 N  NH2   . ARG A 1 575  ? 143.141 186.795 171.967 1.00 112.40 ? 920  ARG A NH2   1 
ATOM   1592 N  N     . VAL A 1 576  ? 141.517 182.070 177.881 1.00 109.83 ? 921  VAL A N     1 
ATOM   1593 C  CA    . VAL A 1 576  ? 142.762 181.756 178.573 1.00 109.89 ? 921  VAL A CA    1 
ATOM   1594 C  C     . VAL A 1 576  ? 143.775 181.259 177.553 1.00 109.60 ? 921  VAL A C     1 
ATOM   1595 O  O     . VAL A 1 576  ? 143.427 180.518 176.628 1.00 109.55 ? 921  VAL A O     1 
ATOM   1596 C  CB    . VAL A 1 576  ? 142.556 180.715 179.692 1.00 112.05 ? 921  VAL A CB    1 
ATOM   1597 C  CG1   . VAL A 1 576  ? 141.664 181.283 180.783 1.00 114.08 ? 921  VAL A CG1   1 
ATOM   1598 C  CG2   . VAL A 1 576  ? 141.971 179.442 179.130 1.00 113.00 ? 921  VAL A CG2   1 
ATOM   1599 N  N     . LEU A 1 577  ? 145.028 181.676 177.722 1.00 103.89 ? 922  LEU A N     1 
ATOM   1600 C  CA    . LEU A 1 577  ? 146.099 181.356 176.788 1.00 104.64 ? 922  LEU A CA    1 
ATOM   1601 C  C     . LEU A 1 577  ? 146.961 180.221 177.324 1.00 106.35 ? 922  LEU A C     1 
ATOM   1602 O  O     . LEU A 1 577  ? 147.351 180.217 178.495 1.00 109.31 ? 922  LEU A O     1 
ATOM   1603 C  CB    . LEU A 1 577  ? 146.971 182.582 176.514 1.00 103.71 ? 922  LEU A CB    1 
ATOM   1604 C  CG    . LEU A 1 577  ? 146.649 183.364 175.240 1.00 104.24 ? 922  LEU A CG    1 
ATOM   1605 C  CD1   . LEU A 1 577  ? 145.377 184.176 175.412 1.00 105.60 ? 922  LEU A CD1   1 
ATOM   1606 C  CD2   . LEU A 1 577  ? 147.813 184.259 174.849 1.00 104.12 ? 922  LEU A CD2   1 
ATOM   1607 N  N     . TYR A 1 578  ? 147.279 179.274 176.446 1.00 99.62  ? 923  TYR A N     1 
ATOM   1608 C  CA    . TYR A 1 578  ? 148.031 178.080 176.803 1.00 96.00  ? 923  TYR A CA    1 
ATOM   1609 C  C     . TYR A 1 578  ? 149.213 177.936 175.859 1.00 95.07  ? 923  TYR A C     1 
ATOM   1610 O  O     . TYR A 1 578  ? 149.060 178.084 174.643 1.00 99.38  ? 923  TYR A O     1 
ATOM   1611 C  CB    . TYR A 1 578  ? 147.130 176.850 176.735 1.00 94.19  ? 923  TYR A CB    1 
ATOM   1612 C  CG    . TYR A 1 578  ? 146.368 176.596 178.011 1.00 97.82  ? 923  TYR A CG    1 
ATOM   1613 C  CD1   . TYR A 1 578  ? 147.017 176.573 179.232 1.00 99.18  ? 923  TYR A CD1   1 
ATOM   1614 C  CD2   . TYR A 1 578  ? 144.996 176.416 177.999 1.00 98.58  ? 923  TYR A CD2   1 
ATOM   1615 C  CE1   . TYR A 1 578  ? 146.326 176.348 180.406 1.00 100.39 ? 923  TYR A CE1   1 
ATOM   1616 C  CE2   . TYR A 1 578  ? 144.293 176.191 179.167 1.00 100.60 ? 923  TYR A CE2   1 
ATOM   1617 C  CZ    . TYR A 1 578  ? 144.964 176.161 180.369 1.00 101.45 ? 923  TYR A CZ    1 
ATOM   1618 O  OH    . TYR A 1 578  ? 144.274 175.941 181.538 1.00 98.15  ? 923  TYR A OH    1 
ATOM   1619 N  N     . TYR A 1 579  ? 150.390 177.652 176.418 1.00 86.46  ? 924  TYR A N     1 
ATOM   1620 C  CA    . TYR A 1 579  ? 151.590 177.580 175.592 1.00 90.06  ? 924  TYR A CA    1 
ATOM   1621 C  C     . TYR A 1 579  ? 151.649 176.285 174.792 1.00 89.91  ? 924  TYR A C     1 
ATOM   1622 O  O     . TYR A 1 579  ? 152.105 176.282 173.644 1.00 91.40  ? 924  TYR A O     1 
ATOM   1623 C  CB    . TYR A 1 579  ? 152.842 177.721 176.454 1.00 87.99  ? 924  TYR A CB    1 
ATOM   1624 C  CG    . TYR A 1 579  ? 154.114 177.411 175.701 1.00 87.26  ? 924  TYR A CG    1 
ATOM   1625 C  CD1   . TYR A 1 579  ? 154.646 178.319 174.798 1.00 88.57  ? 924  TYR A CD1   1 
ATOM   1626 C  CD2   . TYR A 1 579  ? 154.774 176.203 175.880 1.00 86.13  ? 924  TYR A CD2   1 
ATOM   1627 C  CE1   . TYR A 1 579  ? 155.804 178.038 174.101 1.00 89.32  ? 924  TYR A CE1   1 
ATOM   1628 C  CE2   . TYR A 1 579  ? 155.932 175.913 175.188 1.00 88.12  ? 924  TYR A CE2   1 
ATOM   1629 C  CZ    . TYR A 1 579  ? 156.443 176.834 174.299 1.00 89.99  ? 924  TYR A CZ    1 
ATOM   1630 O  OH    . TYR A 1 579  ? 157.597 176.550 173.607 1.00 89.65  ? 924  TYR A OH    1 
ATOM   1631 N  N     . SER A 1 580  ? 151.205 175.175 175.375 1.00 79.92  ? 925  SER A N     1 
ATOM   1632 C  CA    . SER A 1 580  ? 151.373 173.873 174.749 1.00 77.60  ? 925  SER A CA    1 
ATOM   1633 C  C     . SER A 1 580  ? 150.090 173.067 174.872 1.00 77.12  ? 925  SER A C     1 
ATOM   1634 O  O     . SER A 1 580  ? 149.179 173.412 175.627 1.00 81.81  ? 925  SER A O     1 
ATOM   1635 C  CB    . SER A 1 580  ? 152.540 173.102 175.371 1.00 83.75  ? 925  SER A CB    1 
ATOM   1636 O  OG    . SER A 1 580  ? 152.277 171.712 175.377 1.00 87.68  ? 925  SER A OG    1 
ATOM   1637 N  N     . ALA A 1 581  ? 150.031 171.978 174.110 1.00 71.09  ? 926  ALA A N     1 
ATOM   1638 C  CA    . ALA A 1 581  ? 148.916 171.047 174.166 1.00 72.31  ? 926  ALA A CA    1 
ATOM   1639 C  C     . ALA A 1 581  ? 149.410 169.685 173.707 1.00 73.61  ? 926  ALA A C     1 
ATOM   1640 O  O     . ALA A 1 581  ? 150.480 169.565 173.108 1.00 78.22  ? 926  ALA A O     1 
ATOM   1641 C  CB    . ALA A 1 581  ? 147.739 171.515 173.305 1.00 71.59  ? 926  ALA A CB    1 
ATOM   1642 N  N     . THR A 1 582  ? 148.621 168.653 173.991 1.00 73.72  ? 927  THR A N     1 
ATOM   1643 C  CA    . THR A 1 582  ? 149.008 167.291 173.657 1.00 77.26  ? 927  THR A CA    1 
ATOM   1644 C  C     . THR A 1 582  ? 147.806 166.558 173.087 1.00 75.47  ? 927  THR A C     1 
ATOM   1645 O  O     . THR A 1 582  ? 146.710 166.625 173.654 1.00 78.90  ? 927  THR A O     1 
ATOM   1646 C  CB    . THR A 1 582  ? 149.549 166.556 174.890 1.00 83.72  ? 927  THR A CB    1 
ATOM   1647 O  OG1   . THR A 1 582  ? 150.866 167.032 175.191 1.00 85.61  ? 927  THR A OG1   1 
ATOM   1648 C  CG2   . THR A 1 582  ? 149.604 165.055 174.647 1.00 80.69  ? 927  THR A CG2   1 
ATOM   1649 N  N     . LYS A 1 583  ? 148.015 165.865 171.970 1.00 75.01  ? 928  LYS A N     1 
ATOM   1650 C  CA    . LYS A 1 583  ? 146.965 165.072 171.349 1.00 78.99  ? 928  LYS A CA    1 
ATOM   1651 C  C     . LYS A 1 583  ? 147.578 163.825 170.735 1.00 82.09  ? 928  LYS A C     1 
ATOM   1652 O  O     . LYS A 1 583  ? 148.526 163.922 169.950 1.00 83.90  ? 928  LYS A O     1 
ATOM   1653 C  CB    . LYS A 1 583  ? 146.219 165.877 170.279 1.00 81.84  ? 928  LYS A CB    1 
ATOM   1654 C  CG    . LYS A 1 583  ? 144.930 165.231 169.803 1.00 81.28  ? 928  LYS A CG    1 
ATOM   1655 C  CD    . LYS A 1 583  ? 144.368 165.947 168.589 1.00 77.14  ? 928  LYS A CD    1 
ATOM   1656 C  CE    . LYS A 1 583  ? 145.321 165.861 167.411 1.00 79.81  ? 928  LYS A CE    1 
ATOM   1657 N  NZ    . LYS A 1 583  ? 145.407 164.481 166.862 1.00 80.28  ? 928  LYS A NZ    1 
ATOM   1658 N  N     . ASN A 1 584  ? 147.040 162.662 171.106 1.00 86.42  ? 929  ASN A N     1 
ATOM   1659 C  CA    . ASN A 1 584  ? 147.469 161.376 170.555 1.00 89.12  ? 929  ASN A CA    1 
ATOM   1660 C  C     . ASN A 1 584  ? 148.974 161.173 170.712 1.00 89.53  ? 929  ASN A C     1 
ATOM   1661 O  O     . ASN A 1 584  ? 149.643 160.615 169.841 1.00 87.02  ? 929  ASN A O     1 
ATOM   1662 C  CB    . ASN A 1 584  ? 147.052 161.242 169.092 1.00 86.59  ? 929  ASN A CB    1 
ATOM   1663 C  CG    . ASN A 1 584  ? 145.560 161.060 168.931 1.00 87.48  ? 929  ASN A CG    1 
ATOM   1664 O  OD1   . ASN A 1 584  ? 144.770 161.852 169.443 1.00 88.87  ? 929  ASN A OD1   1 
ATOM   1665 N  ND2   . ASN A 1 584  ? 145.164 160.013 168.219 1.00 88.46  ? 929  ASN A ND2   1 
ATOM   1666 N  N     . GLY A 1 585  ? 149.512 161.637 171.835 1.00 85.81  ? 930  GLY A N     1 
ATOM   1667 C  CA    . GLY A 1 585  ? 150.920 161.480 172.121 1.00 87.11  ? 930  GLY A CA    1 
ATOM   1668 C  C     . GLY A 1 585  ? 151.835 162.465 171.430 1.00 87.94  ? 930  GLY A C     1 
ATOM   1669 O  O     . GLY A 1 585  ? 153.055 162.382 171.616 1.00 87.81  ? 930  GLY A O     1 
ATOM   1670 N  N     . ILE A 1 586  ? 151.296 163.394 170.646 1.00 76.12  ? 931  ILE A N     1 
ATOM   1671 C  CA    . ILE A 1 586  ? 152.088 164.401 169.951 1.00 72.68  ? 931  ILE A CA    1 
ATOM   1672 C  C     . ILE A 1 586  ? 151.909 165.729 170.670 1.00 70.63  ? 931  ILE A C     1 
ATOM   1673 O  O     . ILE A 1 586  ? 150.785 166.105 171.026 1.00 73.74  ? 931  ILE A O     1 
ATOM   1674 C  CB    . ILE A 1 586  ? 151.689 164.518 168.470 1.00 74.21  ? 931  ILE A CB    1 
ATOM   1675 C  CG1   . ILE A 1 586  ? 151.251 163.158 167.927 1.00 76.01  ? 931  ILE A CG1   1 
ATOM   1676 C  CG2   . ILE A 1 586  ? 152.850 165.059 167.655 1.00 75.08  ? 931  ILE A CG2   1 
ATOM   1677 C  CD1   . ILE A 1 586  ? 150.960 163.159 166.443 1.00 74.83  ? 931  ILE A CD1   1 
ATOM   1678 N  N     . LEU A 1 587  ? 153.017 166.430 170.888 1.00 60.28  ? 932  LEU A N     1 
ATOM   1679 C  CA    . LEU A 1 587  ? 153.029 167.688 171.621 1.00 62.99  ? 932  LEU A CA    1 
ATOM   1680 C  C     . LEU A 1 587  ? 153.050 168.846 170.634 1.00 65.31  ? 932  LEU A C     1 
ATOM   1681 O  O     . LEU A 1 587  ? 154.016 169.008 169.882 1.00 70.35  ? 932  LEU A O     1 
ATOM   1682 C  CB    . LEU A 1 587  ? 154.242 167.757 172.548 1.00 65.15  ? 932  LEU A CB    1 
ATOM   1683 C  CG    . LEU A 1 587  ? 154.255 168.861 173.605 1.00 65.48  ? 932  LEU A CG    1 
ATOM   1684 C  CD1   . LEU A 1 587  ? 153.864 168.304 174.964 1.00 65.04  ? 932  LEU A CD1   1 
ATOM   1685 C  CD2   . LEU A 1 587  ? 155.620 169.526 173.667 1.00 65.42  ? 932  LEU A CD2   1 
ATOM   1686 N  N     . TYR A 1 588  ? 151.992 169.650 170.643 1.00 55.41  ? 933  TYR A N     1 
ATOM   1687 C  CA    . TYR A 1 588  ? 151.893 170.829 169.797 1.00 54.44  ? 933  TYR A CA    1 
ATOM   1688 C  C     . TYR A 1 588  ? 152.188 172.070 170.624 1.00 56.98  ? 933  TYR A C     1 
ATOM   1689 O  O     . TYR A 1 588  ? 151.768 172.173 171.780 1.00 62.71  ? 933  TYR A O     1 
ATOM   1690 C  CB    . TYR A 1 588  ? 150.506 170.936 169.164 1.00 50.53  ? 933  TYR A CB    1 
ATOM   1691 C  CG    . TYR A 1 588  ? 150.112 169.714 168.375 1.00 51.11  ? 933  TYR A CG    1 
ATOM   1692 C  CD1   . TYR A 1 588  ? 149.476 168.648 168.987 1.00 58.91  ? 933  TYR A CD1   1 
ATOM   1693 C  CD2   . TYR A 1 588  ? 150.382 169.622 167.021 1.00 51.36  ? 933  TYR A CD2   1 
ATOM   1694 C  CE1   . TYR A 1 588  ? 149.119 167.527 168.274 1.00 58.24  ? 933  TYR A CE1   1 
ATOM   1695 C  CE2   . TYR A 1 588  ? 150.029 168.505 166.301 1.00 51.05  ? 933  TYR A CE2   1 
ATOM   1696 C  CZ    . TYR A 1 588  ? 149.395 167.461 166.933 1.00 55.55  ? 933  TYR A CZ    1 
ATOM   1697 O  OH    . TYR A 1 588  ? 149.038 166.341 166.223 1.00 57.57  ? 933  TYR A OH    1 
ATOM   1698 N  N     . ARG A 1 589  ? 152.921 173.006 170.033 1.00 56.75  ? 934  ARG A N     1 
ATOM   1699 C  CA    . ARG A 1 589  ? 153.317 174.215 170.732 1.00 61.47  ? 934  ARG A CA    1 
ATOM   1700 C  C     . ARG A 1 589  ? 153.103 175.417 169.828 1.00 62.66  ? 934  ARG A C     1 
ATOM   1701 O  O     . ARG A 1 589  ? 153.019 175.294 168.605 1.00 64.44  ? 934  ARG A O     1 
ATOM   1702 C  CB    . ARG A 1 589  ? 154.780 174.156 171.187 1.00 64.98  ? 934  ARG A CB    1 
ATOM   1703 C  CG    . ARG A 1 589  ? 155.034 173.216 172.350 1.00 65.65  ? 934  ARG A CG    1 
ATOM   1704 C  CD    . ARG A 1 589  ? 156.507 173.173 172.712 1.00 64.53  ? 934  ARG A CD    1 
ATOM   1705 N  NE    . ARG A 1 589  ? 157.278 172.386 171.758 1.00 66.98  ? 934  ARG A NE    1 
ATOM   1706 C  CZ    . ARG A 1 589  ? 157.986 172.899 170.762 1.00 66.53  ? 934  ARG A CZ    1 
ATOM   1707 N  NH1   . ARG A 1 589  ? 158.046 174.205 170.558 1.00 63.79  ? 934  ARG A NH1   1 
ATOM   1708 N  NH2   . ARG A 1 589  ? 158.649 172.082 169.949 1.00 62.74  ? 934  ARG A NH2   1 
ATOM   1709 N  N     . VAL A 1 590  ? 153.008 176.588 170.457 1.00 60.95  ? 935  VAL A N     1 
ATOM   1710 C  CA    . VAL A 1 590  ? 152.894 177.834 169.712 1.00 62.07  ? 935  VAL A CA    1 
ATOM   1711 C  C     . VAL A 1 590  ? 154.132 178.003 168.844 1.00 68.91  ? 935  VAL A C     1 
ATOM   1712 O  O     . VAL A 1 590  ? 155.256 178.100 169.351 1.00 77.05  ? 935  VAL A O     1 
ATOM   1713 C  CB    . VAL A 1 590  ? 152.714 179.014 170.669 1.00 61.98  ? 935  VAL A CB    1 
ATOM   1714 C  CG1   . VAL A 1 590  ? 152.958 180.328 169.949 1.00 63.04  ? 935  VAL A CG1   1 
ATOM   1715 C  CG2   . VAL A 1 590  ? 151.329 178.983 171.290 1.00 64.91  ? 935  VAL A CG2   1 
ATOM   1716 N  N     . GLY A 1 591  ? 153.932 178.043 167.532 1.00 58.97  ? 936  GLY A N     1 
ATOM   1717 C  CA    . GLY A 1 591  ? 155.027 178.162 166.595 1.00 53.49  ? 936  GLY A CA    1 
ATOM   1718 C  C     . GLY A 1 591  ? 155.387 176.900 165.844 1.00 54.98  ? 936  GLY A C     1 
ATOM   1719 O  O     . GLY A 1 591  ? 156.383 176.903 165.113 1.00 63.09  ? 936  GLY A O     1 
ATOM   1720 N  N     . ASP A 1 592  ? 154.621 175.827 166.001 1.00 53.60  ? 937  ASP A N     1 
ATOM   1721 C  CA    . ASP A 1 592  ? 154.878 174.584 165.293 1.00 53.72  ? 937  ASP A CA    1 
ATOM   1722 C  C     . ASP A 1 592  ? 154.115 174.587 163.970 1.00 55.35  ? 937  ASP A C     1 
ATOM   1723 O  O     . ASP A 1 592  ? 153.606 175.617 163.524 1.00 59.77  ? 937  ASP A O     1 
ATOM   1724 C  CB    . ASP A 1 592  ? 154.501 173.392 166.170 1.00 56.13  ? 937  ASP A CB    1 
ATOM   1725 C  CG    . ASP A 1 592  ? 155.703 172.766 166.848 1.00 67.10  ? 937  ASP A CG    1 
ATOM   1726 O  OD1   . ASP A 1 592  ? 156.821 173.300 166.692 1.00 72.55  ? 937  ASP A OD1   1 
ATOM   1727 O  OD2   . ASP A 1 592  ? 155.532 171.742 167.541 1.00 64.84  ? 937  ASP A OD2   1 
ATOM   1728 N  N     . GLY A 1 593  ? 154.043 173.437 163.321 1.00 48.06  ? 938  GLY A N     1 
ATOM   1729 C  CA    . GLY A 1 593  ? 153.285 173.286 162.087 1.00 47.91  ? 938  GLY A CA    1 
ATOM   1730 C  C     . GLY A 1 593  ? 152.213 172.230 162.258 1.00 47.62  ? 938  GLY A C     1 
ATOM   1731 O  O     . GLY A 1 593  ? 152.417 171.241 162.962 1.00 57.37  ? 938  GLY A O     1 
ATOM   1732 N  N     . VAL A 1 594  ? 151.069 172.448 161.616 1.00 34.50  ? 939  VAL A N     1 
ATOM   1733 C  CA    . VAL A 1 594  ? 149.912 171.576 161.769 1.00 41.52  ? 939  VAL A CA    1 
ATOM   1734 C  C     . VAL A 1 594  ? 149.298 171.285 160.409 1.00 39.38  ? 939  VAL A C     1 
ATOM   1735 O  O     . VAL A 1 594  ? 149.170 172.180 159.565 1.00 49.80  ? 939  VAL A O     1 
ATOM   1736 C  CB    . VAL A 1 594  ? 148.858 172.188 162.713 1.00 38.89  ? 939  VAL A CB    1 
ATOM   1737 C  CG1   . VAL A 1 594  ? 149.382 172.230 164.131 1.00 45.30  ? 939  VAL A CG1   1 
ATOM   1738 C  CG2   . VAL A 1 594  ? 148.479 173.578 162.255 1.00 40.97  ? 939  VAL A CG2   1 
ATOM   1739 N  N     . TYR A 1 595  ? 148.930 170.025 160.199 1.00 27.63  ? 940  TYR A N     1 
ATOM   1740 C  CA    . TYR A 1 595  ? 148.088 169.633 159.081 1.00 27.17  ? 940  TYR A CA    1 
ATOM   1741 C  C     . TYR A 1 595  ? 146.632 169.793 159.489 1.00 32.54  ? 940  TYR A C     1 
ATOM   1742 O  O     . TYR A 1 595  ? 146.260 169.456 160.615 1.00 58.90  ? 940  TYR A O     1 
ATOM   1743 C  CB    . TYR A 1 595  ? 148.342 168.183 158.672 1.00 49.05  ? 940  TYR A CB    1 
ATOM   1744 C  CG    . TYR A 1 595  ? 149.743 167.868 158.212 1.00 45.67  ? 940  TYR A CG    1 
ATOM   1745 C  CD1   . TYR A 1 595  ? 150.585 168.862 157.750 1.00 40.29  ? 940  TYR A CD1   1 
ATOM   1746 C  CD2   . TYR A 1 595  ? 150.221 166.567 158.239 1.00 41.86  ? 940  TYR A CD2   1 
ATOM   1747 C  CE1   . TYR A 1 595  ? 151.861 168.572 157.332 1.00 42.90  ? 940  TYR A CE1   1 
ATOM   1748 C  CE2   . TYR A 1 595  ? 151.496 166.270 157.826 1.00 43.22  ? 940  TYR A CE2   1 
ATOM   1749 C  CZ    . TYR A 1 595  ? 152.312 167.276 157.375 1.00 49.00  ? 940  TYR A CZ    1 
ATOM   1750 O  OH    . TYR A 1 595  ? 153.586 166.984 156.958 1.00 50.70  ? 940  TYR A OH    1 
ATOM   1751 N  N     . LEU A 1 596  ? 145.815 170.293 158.578 1.00 37.38  ? 941  LEU A N     1 
ATOM   1752 C  CA    . LEU A 1 596  ? 144.381 170.396 158.764 1.00 37.09  ? 941  LEU A CA    1 
ATOM   1753 C  C     . LEU A 1 596  ? 143.678 169.770 157.568 1.00 49.65  ? 941  LEU A C     1 
ATOM   1754 O  O     . LEU A 1 596  ? 144.263 169.658 156.486 1.00 58.38  ? 941  LEU A O     1 
ATOM   1755 C  CB    . LEU A 1 596  ? 143.959 171.863 158.919 1.00 41.05  ? 941  LEU A CB    1 
ATOM   1756 C  CG    . LEU A 1 596  ? 144.562 172.613 160.105 1.00 37.05  ? 941  LEU A CG    1 
ATOM   1757 C  CD1   . LEU A 1 596  ? 144.532 174.108 159.867 1.00 42.30  ? 941  LEU A CD1   1 
ATOM   1758 C  CD2   . LEU A 1 596  ? 143.824 172.266 161.378 1.00 45.35  ? 941  LEU A CD2   1 
ATOM   1759 N  N     . PRO A 1 597  ? 142.434 169.334 157.728 1.00 53.65  ? 942  PRO A N     1 
ATOM   1760 C  CA    . PRO A 1 597  ? 141.707 168.739 156.604 1.00 61.77  ? 942  PRO A CA    1 
ATOM   1761 C  C     . PRO A 1 597  ? 141.463 169.766 155.513 1.00 65.07  ? 942  PRO A C     1 
ATOM   1762 O  O     . PRO A 1 597  ? 141.513 170.978 155.770 1.00 65.23  ? 942  PRO A O     1 
ATOM   1763 C  CB    . PRO A 1 597  ? 140.388 168.273 157.240 1.00 61.91  ? 942  PRO A CB    1 
ATOM   1764 C  CG    . PRO A 1 597  ? 140.669 168.192 158.695 1.00 62.00  ? 942  PRO A CG    1 
ATOM   1765 C  CD    . PRO A 1 597  ? 141.659 169.269 158.976 1.00 52.69  ? 942  PRO A CD    1 
ATOM   1766 N  N     . PRO A 1 598  ? 141.206 169.325 154.279 1.00 56.50  ? 943  PRO A N     1 
ATOM   1767 C  CA    . PRO A 1 598  ? 140.985 170.288 153.189 1.00 48.20  ? 943  PRO A CA    1 
ATOM   1768 C  C     . PRO A 1 598  ? 139.793 171.197 153.413 1.00 63.31  ? 943  PRO A C     1 
ATOM   1769 O  O     . PRO A 1 598  ? 139.701 172.245 152.763 1.00 69.18  ? 943  PRO A O     1 
ATOM   1770 C  CB    . PRO A 1 598  ? 140.779 169.390 151.962 1.00 48.59  ? 943  PRO A CB    1 
ATOM   1771 C  CG    . PRO A 1 598  ? 141.392 168.087 152.333 1.00 58.75  ? 943  PRO A CG    1 
ATOM   1772 C  CD    . PRO A 1 598  ? 141.170 167.935 153.800 1.00 59.80  ? 943  PRO A CD    1 
ATOM   1773 N  N     . GLU A 1 599  ? 138.875 170.831 154.302 1.00 67.62  ? 944  GLU A N     1 
ATOM   1774 C  CA    . GLU A 1 599  ? 137.701 171.636 154.597 1.00 65.32  ? 944  GLU A CA    1 
ATOM   1775 C  C     . GLU A 1 599  ? 137.886 172.521 155.822 1.00 67.44  ? 944  GLU A C     1 
ATOM   1776 O  O     . GLU A 1 599  ? 136.922 173.150 156.267 1.00 77.78  ? 944  GLU A O     1 
ATOM   1777 C  CB    . GLU A 1 599  ? 136.485 170.730 154.791 1.00 68.45  ? 944  GLU A CB    1 
ATOM   1778 C  CG    . GLU A 1 599  ? 136.811 169.415 155.477 1.00 71.31  ? 944  GLU A CG    1 
ATOM   1779 C  CD    . GLU A 1 599  ? 135.778 168.343 155.203 1.00 75.02  ? 944  GLU A CD    1 
ATOM   1780 O  OE1   . GLU A 1 599  ? 134.581 168.682 155.095 1.00 76.65  ? 944  GLU A OE1   1 
ATOM   1781 O  OE2   . GLU A 1 599  ? 136.164 167.160 155.095 1.00 75.92  ? 944  GLU A OE2   1 
ATOM   1782 N  N     . ALA A 1 600  ? 139.096 172.576 156.384 1.00 53.59  ? 945  ALA A N     1 
ATOM   1783 C  CA    . ALA A 1 600  ? 139.309 173.347 157.606 1.00 59.97  ? 945  ALA A CA    1 
ATOM   1784 C  C     . ALA A 1 600  ? 139.077 174.833 157.370 1.00 63.47  ? 945  ALA A C     1 
ATOM   1785 O  O     . ALA A 1 600  ? 138.405 175.502 158.164 1.00 65.31  ? 945  ALA A O     1 
ATOM   1786 C  CB    . ALA A 1 600  ? 140.716 173.102 158.143 1.00 59.87  ? 945  ALA A CB    1 
ATOM   1787 N  N     . PHE A 1 601  ? 139.623 175.368 156.284 1.00 58.62  ? 946  PHE A N     1 
ATOM   1788 C  CA    . PHE A 1 601  ? 139.394 176.760 155.921 1.00 60.10  ? 946  PHE A CA    1 
ATOM   1789 C  C     . PHE A 1 601  ? 139.637 176.916 154.426 1.00 59.99  ? 946  PHE A C     1 
ATOM   1790 O  O     . PHE A 1 601  ? 139.984 175.960 153.728 1.00 57.81  ? 946  PHE A O     1 
ATOM   1791 C  CB    . PHE A 1 601  ? 140.269 177.712 156.748 1.00 60.66  ? 946  PHE A CB    1 
ATOM   1792 C  CG    . PHE A 1 601  ? 141.749 177.499 156.579 1.00 61.32  ? 946  PHE A CG    1 
ATOM   1793 C  CD1   . PHE A 1 601  ? 142.431 178.063 155.516 1.00 59.17  ? 946  PHE A CD1   1 
ATOM   1794 C  CD2   . PHE A 1 601  ? 142.463 176.759 157.503 1.00 59.05  ? 946  PHE A CD2   1 
ATOM   1795 C  CE1   . PHE A 1 601  ? 143.789 177.872 155.367 1.00 53.83  ? 946  PHE A CE1   1 
ATOM   1796 C  CE2   . PHE A 1 601  ? 143.822 176.570 157.357 1.00 57.59  ? 946  PHE A CE2   1 
ATOM   1797 C  CZ    . PHE A 1 601  ? 144.484 177.127 156.289 1.00 52.07  ? 946  PHE A CZ    1 
ATOM   1798 N  N     . THR A 1 602  ? 139.434 178.135 153.936 1.00 69.41  ? 947  THR A N     1 
ATOM   1799 C  CA    . THR A 1 602  ? 139.663 178.465 152.539 1.00 69.29  ? 947  THR A CA    1 
ATOM   1800 C  C     . THR A 1 602  ? 140.406 179.789 152.463 1.00 67.43  ? 947  THR A C     1 
ATOM   1801 O  O     . THR A 1 602  ? 140.332 180.620 153.371 1.00 67.29  ? 947  THR A O     1 
ATOM   1802 C  CB    . THR A 1 602  ? 138.353 178.548 151.747 1.00 68.49  ? 947  THR A CB    1 
ATOM   1803 O  OG1   . THR A 1 602  ? 137.428 179.396 152.438 1.00 71.68  ? 947  THR A OG1   1 
ATOM   1804 C  CG2   . THR A 1 602  ? 137.743 177.166 151.579 1.00 63.82  ? 947  THR A CG2   1 
ATOM   1805 N  N     . PHE A 1 603  ? 141.128 179.976 151.365 1.00 56.89  ? 948  PHE A N     1 
ATOM   1806 C  CA    . PHE A 1 603  ? 141.942 181.165 151.193 1.00 62.96  ? 948  PHE A CA    1 
ATOM   1807 C  C     . PHE A 1 603  ? 141.097 182.325 150.671 1.00 64.66  ? 948  PHE A C     1 
ATOM   1808 O  O     . PHE A 1 603  ? 139.968 182.153 150.207 1.00 68.92  ? 948  PHE A O     1 
ATOM   1809 C  CB    . PHE A 1 603  ? 143.105 180.877 150.250 1.00 62.45  ? 948  PHE A CB    1 
ATOM   1810 C  CG    . PHE A 1 603  ? 143.896 179.659 150.625 1.00 59.68  ? 948  PHE A CG    1 
ATOM   1811 C  CD1   . PHE A 1 603  ? 144.947 179.750 151.516 1.00 56.49  ? 948  PHE A CD1   1 
ATOM   1812 C  CD2   . PHE A 1 603  ? 143.582 178.423 150.091 1.00 58.02  ? 948  PHE A CD2   1 
ATOM   1813 C  CE1   . PHE A 1 603  ? 145.672 178.634 151.864 1.00 56.03  ? 948  PHE A CE1   1 
ATOM   1814 C  CE2   . PHE A 1 603  ? 144.305 177.303 150.437 1.00 54.79  ? 948  PHE A CE2   1 
ATOM   1815 C  CZ    . PHE A 1 603  ? 145.351 177.410 151.325 1.00 54.28  ? 948  PHE A CZ    1 
ATOM   1816 N  N     . ASN A 1 604  ? 141.665 183.529 150.757 1.00 73.75  ? 949  ASN A N     1 
ATOM   1817 C  CA    . ASN A 1 604  ? 140.966 184.718 150.285 1.00 77.34  ? 949  ASN A CA    1 
ATOM   1818 C  C     . ASN A 1 604  ? 140.918 184.802 148.765 1.00 79.40  ? 949  ASN A C     1 
ATOM   1819 O  O     . ASN A 1 604  ? 140.119 185.575 148.227 1.00 79.42  ? 949  ASN A O     1 
ATOM   1820 C  CB    . ASN A 1 604  ? 141.627 185.975 150.851 1.00 73.96  ? 949  ASN A CB    1 
ATOM   1821 C  CG    . ASN A 1 604  ? 141.471 186.088 152.353 1.00 78.67  ? 949  ASN A CG    1 
ATOM   1822 O  OD1   . ASN A 1 604  ? 140.906 185.204 152.997 1.00 79.00  ? 949  ASN A OD1   1 
ATOM   1823 N  ND2   . ASN A 1 604  ? 141.972 187.178 152.920 1.00 79.71  ? 949  ASN A ND2   1 
ATOM   1824 N  N     . ILE A 1 605  ? 141.749 184.036 148.067 1.00 81.63  ? 950  ILE A N     1 
ATOM   1825 C  CA    . ILE A 1 605  ? 141.785 184.072 146.609 1.00 82.73  ? 950  ILE A CA    1 
ATOM   1826 C  C     . ILE A 1 605  ? 140.561 183.354 146.059 1.00 85.56  ? 950  ILE A C     1 
ATOM   1827 O  O     . ILE A 1 605  ? 140.265 182.218 146.447 1.00 80.65  ? 950  ILE A O     1 
ATOM   1828 C  CB    . ILE A 1 605  ? 143.082 183.441 146.081 1.00 78.00  ? 950  ILE A CB    1 
ATOM   1829 C  CG1   . ILE A 1 605  ? 144.292 184.279 146.494 1.00 74.68  ? 950  ILE A CG1   1 
ATOM   1830 C  CG2   . ILE A 1 605  ? 143.024 183.289 144.572 1.00 78.79  ? 950  ILE A CG2   1 
ATOM   1831 C  CD1   . ILE A 1 605  ? 144.519 185.484 145.616 1.00 78.51  ? 950  ILE A CD1   1 
ATOM   1832 N  N     . LYS A 1 606  ? 139.846 184.018 145.154 1.00 100.71 ? 951  LYS A N     1 
ATOM   1833 C  CA    . LYS A 1 606  ? 138.678 183.413 144.529 1.00 99.26  ? 951  LYS A CA    1 
ATOM   1834 C  C     . LYS A 1 606  ? 139.091 182.242 143.647 1.00 101.91 ? 951  LYS A C     1 
ATOM   1835 O  O     . LYS A 1 606  ? 140.112 182.292 142.955 1.00 101.03 ? 951  LYS A O     1 
ATOM   1836 C  CB    . LYS A 1 606  ? 137.921 184.452 143.703 1.00 97.55  ? 951  LYS A CB    1 
ATOM   1837 C  CG    . LYS A 1 606  ? 138.117 185.883 144.176 1.00 99.56  ? 951  LYS A CG    1 
ATOM   1838 C  CD    . LYS A 1 606  ? 137.243 186.192 145.381 1.00 101.14 ? 951  LYS A CD    1 
ATOM   1839 C  CE    . LYS A 1 606  ? 137.616 187.526 146.008 1.00 101.29 ? 951  LYS A CE    1 
ATOM   1840 N  NZ    . LYS A 1 606  ? 137.183 188.678 145.171 1.00 99.65  ? 951  LYS A NZ    1 
ATOM   1841 N  N     . LEU A 1 607  ? 138.286 181.184 143.671 1.00 105.58 ? 952  LEU A N     1 
ATOM   1842 C  CA    . LEU A 1 607  ? 138.564 179.966 142.923 1.00 104.51 ? 952  LEU A CA    1 
ATOM   1843 C  C     . LEU A 1 607  ? 137.714 179.934 141.659 1.00 107.08 ? 952  LEU A C     1 
ATOM   1844 O  O     . LEU A 1 607  ? 136.499 180.153 141.719 1.00 105.92 ? 952  LEU A O     1 
ATOM   1845 C  CB    . LEU A 1 607  ? 138.288 178.729 143.780 1.00 102.88 ? 952  LEU A CB    1 
ATOM   1846 C  CG    . LEU A 1 607  ? 138.431 177.359 143.113 1.00 104.71 ? 952  LEU A CG    1 
ATOM   1847 C  CD1   . LEU A 1 607  ? 139.757 177.241 142.377 1.00 104.57 ? 952  LEU A CD1   1 
ATOM   1848 C  CD2   . LEU A 1 607  ? 138.288 176.249 144.142 1.00 103.64 ? 952  LEU A CD2   1 
ATOM   1849 N  N     . SER A 1 608  ? 138.359 179.662 140.526 1.00 115.26 ? 953  SER A N     1 
ATOM   1850 C  CA    . SER A 1 608  ? 137.691 179.575 139.228 1.00 115.32 ? 953  SER A CA    1 
ATOM   1851 C  C     . SER A 1 608  ? 136.915 180.847 138.900 1.00 113.38 ? 953  SER A C     1 
ATOM   1852 O  O     . SER A 1 608  ? 137.497 181.924 138.774 1.00 112.89 ? 953  SER A O     1 
ATOM   1853 C  CB    . SER A 1 608  ? 136.755 178.365 139.184 1.00 114.78 ? 953  SER A CB    1 
ATOM   1854 O  OG    . SER A 1 608  ? 136.252 178.156 137.876 1.00 112.07 ? 953  SER A OG    1 
ATOM   1855 N  N     . GLU A 1 617  ? 127.837 166.454 121.415 1.00 130.77 ? 962  GLU A N     1 
ATOM   1856 C  CA    . GLU A 1 617  ? 127.662 166.424 119.968 1.00 131.13 ? 962  GLU A CA    1 
ATOM   1857 C  C     . GLU A 1 617  ? 127.717 164.992 119.442 1.00 130.30 ? 962  GLU A C     1 
ATOM   1858 O  O     . GLU A 1 617  ? 128.543 164.192 119.883 1.00 130.51 ? 962  GLU A O     1 
ATOM   1859 C  CB    . GLU A 1 617  ? 128.725 167.289 119.282 1.00 130.36 ? 962  GLU A CB    1 
ATOM   1860 C  CG    . GLU A 1 617  ? 130.161 166.841 119.518 1.00 131.52 ? 962  GLU A CG    1 
ATOM   1861 C  CD    . GLU A 1 617  ? 130.763 167.433 120.779 1.00 132.44 ? 962  GLU A CD    1 
ATOM   1862 O  OE1   . GLU A 1 617  ? 130.076 167.449 121.822 1.00 131.43 ? 962  GLU A OE1   1 
ATOM   1863 O  OE2   . GLU A 1 617  ? 131.927 167.883 120.726 1.00 132.10 ? 962  GLU A OE2   1 
ATOM   1864 N  N     . PRO A 1 618  ? 126.826 164.662 118.507 1.00 119.49 ? 963  PRO A N     1 
ATOM   1865 C  CA    . PRO A 1 618  ? 126.795 163.307 117.941 1.00 116.95 ? 963  PRO A CA    1 
ATOM   1866 C  C     . PRO A 1 618  ? 127.790 163.167 116.800 1.00 117.74 ? 963  PRO A C     1 
ATOM   1867 O  O     . PRO A 1 618  ? 127.643 163.792 115.745 1.00 118.89 ? 963  PRO A O     1 
ATOM   1868 C  CB    . PRO A 1 618  ? 125.343 163.168 117.458 1.00 119.65 ? 963  PRO A CB    1 
ATOM   1869 C  CG    . PRO A 1 618  ? 124.800 164.584 117.361 1.00 120.92 ? 963  PRO A CG    1 
ATOM   1870 C  CD    . PRO A 1 618  ? 125.834 165.544 117.876 1.00 120.10 ? 963  PRO A CD    1 
ATOM   1871 N  N     . VAL A 1 619  ? 128.812 162.335 117.009 1.00 107.94 ? 964  VAL A N     1 
ATOM   1872 C  CA    . VAL A 1 619  ? 129.787 162.095 115.954 1.00 106.91 ? 964  VAL A CA    1 
ATOM   1873 C  C     . VAL A 1 619  ? 129.166 161.231 114.862 1.00 105.11 ? 964  VAL A C     1 
ATOM   1874 O  O     . VAL A 1 619  ? 128.159 160.542 115.063 1.00 105.79 ? 964  VAL A O     1 
ATOM   1875 C  CB    . VAL A 1 619  ? 131.061 161.446 116.519 1.00 105.54 ? 964  VAL A CB    1 
ATOM   1876 C  CG1   . VAL A 1 619  ? 131.914 162.485 117.227 1.00 105.75 ? 964  VAL A CG1   1 
ATOM   1877 C  CG2   . VAL A 1 619  ? 130.700 160.313 117.463 1.00 104.03 ? 964  VAL A CG2   1 
ATOM   1878 N  N     . ASP A 1 620  ? 129.778 161.276 113.682 1.00 100.74 ? 965  ASP A N     1 
ATOM   1879 C  CA    . ASP A 1 620  ? 129.268 160.518 112.549 1.00 101.26 ? 965  ASP A CA    1 
ATOM   1880 C  C     . ASP A 1 620  ? 129.427 159.025 112.801 1.00 101.37 ? 965  ASP A C     1 
ATOM   1881 O  O     . ASP A 1 620  ? 130.513 158.555 113.149 1.00 104.01 ? 965  ASP A O     1 
ATOM   1882 C  CB    . ASP A 1 620  ? 129.997 160.920 111.270 1.00 103.61 ? 965  ASP A CB    1 
ATOM   1883 C  CG    . ASP A 1 620  ? 129.509 160.154 110.059 1.00 104.85 ? 965  ASP A CG    1 
ATOM   1884 O  OD1   . ASP A 1 620  ? 128.296 159.868 109.985 1.00 103.53 ? 965  ASP A OD1   1 
ATOM   1885 O  OD2   . ASP A 1 620  ? 130.339 159.838 109.181 1.00 105.43 ? 965  ASP A OD2   1 
ATOM   1886 N  N     . GLU A 1 621  ? 128.338 158.276 112.622 1.00 106.43 ? 966  GLU A N     1 
ATOM   1887 C  CA    . GLU A 1 621  ? 128.383 156.840 112.862 1.00 107.37 ? 966  GLU A CA    1 
ATOM   1888 C  C     . GLU A 1 621  ? 129.108 156.090 111.755 1.00 106.95 ? 966  GLU A C     1 
ATOM   1889 O  O     . GLU A 1 621  ? 129.557 154.962 111.982 1.00 109.56 ? 966  GLU A O     1 
ATOM   1890 C  CB    . GLU A 1 621  ? 126.967 156.289 113.025 1.00 109.42 ? 966  GLU A CB    1 
ATOM   1891 C  CG    . GLU A 1 621  ? 126.445 156.351 114.449 1.00 109.51 ? 966  GLU A CG    1 
ATOM   1892 C  CD    . GLU A 1 621  ? 124.966 156.040 114.539 1.00 111.81 ? 966  GLU A CD    1 
ATOM   1893 O  OE1   . GLU A 1 621  ? 124.341 155.811 113.482 1.00 112.30 ? 966  GLU A OE1   1 
ATOM   1894 O  OE2   . GLU A 1 621  ? 124.427 156.025 115.665 1.00 112.19 ? 966  GLU A OE2   1 
ATOM   1895 N  N     . ASP A 1 622  ? 129.222 156.677 110.564 1.00 101.58 ? 967  ASP A N     1 
ATOM   1896 C  CA    . ASP A 1 622  ? 129.982 156.028 109.502 1.00 103.62 ? 967  ASP A CA    1 
ATOM   1897 C  C     . ASP A 1 622  ? 131.482 156.147 109.743 1.00 103.42 ? 967  ASP A C     1 
ATOM   1898 O  O     . ASP A 1 622  ? 132.230 155.188 109.518 1.00 101.97 ? 967  ASP A O     1 
ATOM   1899 C  CB    . ASP A 1 622  ? 129.604 156.622 108.147 1.00 103.35 ? 967  ASP A CB    1 
ATOM   1900 C  CG    . ASP A 1 622  ? 128.407 155.935 107.526 1.00 104.92 ? 967  ASP A CG    1 
ATOM   1901 O  OD1   . ASP A 1 622  ? 127.784 155.095 108.209 1.00 105.19 ? 967  ASP A OD1   1 
ATOM   1902 O  OD2   . ASP A 1 622  ? 128.087 156.235 106.357 1.00 105.88 ? 967  ASP A OD2   1 
ATOM   1903 N  N     . LEU A 1 623  ? 131.940 157.314 110.197 1.00 89.54  ? 968  LEU A N     1 
ATOM   1904 C  CA    . LEU A 1 623  ? 133.370 157.521 110.394 1.00 88.27  ? 968  LEU A CA    1 
ATOM   1905 C  C     . LEU A 1 623  ? 133.876 156.835 111.657 1.00 88.05  ? 968  LEU A C     1 
ATOM   1906 O  O     . LEU A 1 623  ? 134.994 156.311 111.672 1.00 91.91  ? 968  LEU A O     1 
ATOM   1907 C  CB    . LEU A 1 623  ? 133.683 159.015 110.442 1.00 87.84  ? 968  LEU A CB    1 
ATOM   1908 C  CG    . LEU A 1 623  ? 134.956 159.441 109.709 1.00 89.53  ? 968  LEU A CG    1 
ATOM   1909 C  CD1   . LEU A 1 623  ? 134.766 159.311 108.208 1.00 90.89  ? 968  LEU A CD1   1 
ATOM   1910 C  CD2   . LEU A 1 623  ? 135.354 160.860 110.082 1.00 87.64  ? 968  LEU A CD2   1 
ATOM   1911 N  N     . TYR A 1 624  ? 133.078 156.827 112.722 1.00 75.20  ? 969  TYR A N     1 
ATOM   1912 C  CA    . TYR A 1 624  ? 133.468 156.242 114.005 1.00 73.05  ? 969  TYR A CA    1 
ATOM   1913 C  C     . TYR A 1 624  ? 132.371 155.286 114.450 1.00 74.77  ? 969  TYR A C     1 
ATOM   1914 O  O     . TYR A 1 624  ? 131.589 155.597 115.358 1.00 72.40  ? 969  TYR A O     1 
ATOM   1915 C  CB    . TYR A 1 624  ? 133.719 157.323 115.055 1.00 73.77  ? 969  TYR A CB    1 
ATOM   1916 C  CG    . TYR A 1 624  ? 134.518 158.499 114.548 1.00 76.15  ? 969  TYR A CG    1 
ATOM   1917 C  CD1   . TYR A 1 624  ? 135.902 158.503 114.616 1.00 76.99  ? 969  TYR A CD1   1 
ATOM   1918 C  CD2   . TYR A 1 624  ? 133.888 159.609 114.007 1.00 78.98  ? 969  TYR A CD2   1 
ATOM   1919 C  CE1   . TYR A 1 624  ? 136.635 159.578 114.156 1.00 78.67  ? 969  TYR A CE1   1 
ATOM   1920 C  CE2   . TYR A 1 624  ? 134.613 160.687 113.544 1.00 78.15  ? 969  TYR A CE2   1 
ATOM   1921 C  CZ    . TYR A 1 624  ? 135.986 160.666 113.621 1.00 77.63  ? 969  TYR A CZ    1 
ATOM   1922 O  OH    . TYR A 1 624  ? 136.712 161.738 113.160 1.00 79.27  ? 969  TYR A OH    1 
ATOM   1923 N  N     . PRO A 1 625  ? 132.287 154.107 113.832 1.00 80.30  ? 970  PRO A N     1 
ATOM   1924 C  CA    . PRO A 1 625  ? 131.189 153.184 114.158 1.00 77.93  ? 970  PRO A CA    1 
ATOM   1925 C  C     . PRO A 1 625  ? 131.222 152.672 115.582 1.00 76.71  ? 970  PRO A C     1 
ATOM   1926 O  O     . PRO A 1 625  ? 130.196 152.181 116.068 1.00 78.00  ? 970  PRO A O     1 
ATOM   1927 C  CB    . PRO A 1 625  ? 131.382 152.043 113.151 1.00 80.58  ? 970  PRO A CB    1 
ATOM   1928 C  CG    . PRO A 1 625  ? 132.826 152.088 112.807 1.00 79.06  ? 970  PRO A CG    1 
ATOM   1929 C  CD    . PRO A 1 625  ? 133.220 153.534 112.849 1.00 81.59  ? 970  PRO A CD    1 
ATOM   1930 N  N     . GLU A 1 626  ? 132.361 152.761 116.267 1.00 69.97  ? 971  GLU A N     1 
ATOM   1931 C  CA    . GLU A 1 626  ? 132.493 152.251 117.624 1.00 72.63  ? 971  GLU A CA    1 
ATOM   1932 C  C     . GLU A 1 626  ? 132.600 153.364 118.658 1.00 74.48  ? 971  GLU A C     1 
ATOM   1933 O  O     . GLU A 1 626  ? 133.101 153.131 119.762 1.00 75.22  ? 971  GLU A O     1 
ATOM   1934 C  CB    . GLU A 1 626  ? 133.698 151.317 117.723 1.00 70.37  ? 971  GLU A CB    1 
ATOM   1935 C  CG    . GLU A 1 626  ? 133.708 150.219 116.681 1.00 73.70  ? 971  GLU A CG    1 
ATOM   1936 C  CD    . GLU A 1 626  ? 132.703 149.130 116.979 1.00 75.90  ? 971  GLU A CD    1 
ATOM   1937 O  OE1   . GLU A 1 626  ? 132.188 149.088 118.116 1.00 72.13  ? 971  GLU A OE1   1 
ATOM   1938 O  OE2   . GLU A 1 626  ? 132.428 148.313 116.077 1.00 78.93  ? 971  GLU A OE2   1 
ATOM   1939 N  N     . HIS A 1 627  ? 132.150 154.571 118.326 1.00 73.38  ? 972  HIS A N     1 
ATOM   1940 C  CA    . HIS A 1 627  ? 132.155 155.644 119.309 1.00 71.93  ? 972  HIS A CA    1 
ATOM   1941 C  C     . HIS A 1 627  ? 130.988 155.563 120.279 1.00 70.92  ? 972  HIS A C     1 
ATOM   1942 O  O     . HIS A 1 627  ? 131.017 156.240 121.311 1.00 70.42  ? 972  HIS A O     1 
ATOM   1943 C  CB    . HIS A 1 627  ? 132.142 157.008 118.620 1.00 73.57  ? 972  HIS A CB    1 
ATOM   1944 C  CG    . HIS A 1 627  ? 132.681 158.112 119.473 1.00 73.81  ? 972  HIS A CG    1 
ATOM   1945 N  ND1   . HIS A 1 627  ? 131.999 158.609 120.562 1.00 74.59  ? 972  HIS A ND1   1 
ATOM   1946 C  CD2   . HIS A 1 627  ? 133.840 158.808 119.404 1.00 76.49  ? 972  HIS A CD2   1 
ATOM   1947 C  CE1   . HIS A 1 627  ? 132.714 159.567 121.126 1.00 78.96  ? 972  HIS A CE1   1 
ATOM   1948 N  NE2   . HIS A 1 627  ? 133.835 159.707 120.442 1.00 80.14  ? 972  HIS A NE2   1 
ATOM   1949 N  N     . TYR A 1 628  ? 129.967 154.759 119.979 1.00 78.04  ? 973  TYR A N     1 
ATOM   1950 C  CA    . TYR A 1 628  ? 128.835 154.631 120.887 1.00 79.28  ? 973  TYR A CA    1 
ATOM   1951 C  C     . TYR A 1 628  ? 129.194 153.898 122.169 1.00 80.08  ? 973  TYR A C     1 
ATOM   1952 O  O     . TYR A 1 628  ? 128.392 153.905 123.108 1.00 85.67  ? 973  TYR A O     1 
ATOM   1953 C  CB    . TYR A 1 628  ? 127.672 153.919 120.191 1.00 77.43  ? 973  TYR A CB    1 
ATOM   1954 C  CG    . TYR A 1 628  ? 127.889 152.441 119.957 1.00 76.62  ? 973  TYR A CG    1 
ATOM   1955 C  CD1   . TYR A 1 628  ? 128.506 151.986 118.802 1.00 78.85  ? 973  TYR A CD1   1 
ATOM   1956 C  CD2   . TYR A 1 628  ? 127.462 151.500 120.884 1.00 77.54  ? 973  TYR A CD2   1 
ATOM   1957 C  CE1   . TYR A 1 628  ? 128.702 150.638 118.582 1.00 81.37  ? 973  TYR A CE1   1 
ATOM   1958 C  CE2   . TYR A 1 628  ? 127.655 150.150 120.672 1.00 78.81  ? 973  TYR A CE2   1 
ATOM   1959 C  CZ    . TYR A 1 628  ? 128.274 149.725 119.519 1.00 80.74  ? 973  TYR A CZ    1 
ATOM   1960 O  OH    . TYR A 1 628  ? 128.467 148.381 119.304 1.00 80.82  ? 973  TYR A OH    1 
ATOM   1961 N  N     . ARG A 1 629  ? 130.366 153.269 122.232 1.00 64.31  ? 974  ARG A N     1 
ATOM   1962 C  CA    . ARG A 1 629  ? 130.774 152.541 123.424 1.00 65.84  ? 974  ARG A CA    1 
ATOM   1963 C  C     . ARG A 1 629  ? 131.301 153.449 124.526 1.00 64.81  ? 974  ARG A C     1 
ATOM   1964 O  O     . ARG A 1 629  ? 131.564 152.963 125.630 1.00 62.65  ? 974  ARG A O     1 
ATOM   1965 C  CB    . ARG A 1 629  ? 131.836 151.502 123.064 1.00 67.52  ? 974  ARG A CB    1 
ATOM   1966 C  CG    . ARG A 1 629  ? 131.302 150.296 122.309 1.00 69.98  ? 974  ARG A CG    1 
ATOM   1967 C  CD    . ARG A 1 629  ? 132.424 149.335 121.959 1.00 62.02  ? 974  ARG A CD    1 
ATOM   1968 N  NE    . ARG A 1 629  ? 132.009 148.355 120.966 1.00 55.19  ? 974  ARG A NE    1 
ATOM   1969 C  CZ    . ARG A 1 629  ? 131.456 147.188 121.260 1.00 63.51  ? 974  ARG A CZ    1 
ATOM   1970 N  NH1   . ARG A 1 629  ? 131.235 146.827 122.511 1.00 66.43  ? 974  ARG A NH1   1 
ATOM   1971 N  NH2   . ARG A 1 629  ? 131.120 146.363 120.273 1.00 66.46  ? 974  ARG A NH2   1 
ATOM   1972 N  N     . LYS A 1 630  ? 131.467 154.742 124.258 1.00 67.14  ? 975  LYS A N     1 
ATOM   1973 C  CA    . LYS A 1 630  ? 131.937 155.689 125.269 1.00 68.19  ? 975  LYS A CA    1 
ATOM   1974 C  C     . LYS A 1 630  ? 130.754 156.327 126.000 1.00 74.95  ? 975  LYS A C     1 
ATOM   1975 O  O     . LYS A 1 630  ? 130.621 157.547 126.086 1.00 78.13  ? 975  LYS A O     1 
ATOM   1976 C  CB    . LYS A 1 630  ? 132.821 156.753 124.629 1.00 69.14  ? 975  LYS A CB    1 
ATOM   1977 C  CG    . LYS A 1 630  ? 134.250 156.326 124.366 1.00 69.56  ? 975  LYS A CG    1 
ATOM   1978 C  CD    . LYS A 1 630  ? 134.999 157.403 123.599 1.00 67.71  ? 975  LYS A CD    1 
ATOM   1979 C  CE    . LYS A 1 630  ? 136.443 157.509 124.049 1.00 64.45  ? 975  LYS A CE    1 
ATOM   1980 N  NZ    . LYS A 1 630  ? 136.557 157.842 125.491 1.00 67.10  ? 975  LYS A NZ    1 
ATOM   1981 N  N     . TYR A 1 631  ? 129.881 155.475 126.535 1.00 89.83  ? 976  TYR A N     1 
ATOM   1982 C  CA    . TYR A 1 631  ? 128.729 155.954 127.286 1.00 90.26  ? 976  TYR A CA    1 
ATOM   1983 C  C     . TYR A 1 631  ? 128.906 155.839 128.794 1.00 91.74  ? 976  TYR A C     1 
ATOM   1984 O  O     . TYR A 1 631  ? 128.080 156.375 129.539 1.00 93.31  ? 976  TYR A O     1 
ATOM   1985 C  CB    . TYR A 1 631  ? 127.456 155.207 126.861 1.00 90.23  ? 976  TYR A CB    1 
ATOM   1986 C  CG    . TYR A 1 631  ? 127.495 153.703 127.037 1.00 92.44  ? 976  TYR A CG    1 
ATOM   1987 C  CD1   . TYR A 1 631  ? 127.332 153.122 128.288 1.00 89.99  ? 976  TYR A CD1   1 
ATOM   1988 C  CD2   . TYR A 1 631  ? 127.670 152.863 125.946 1.00 92.24  ? 976  TYR A CD2   1 
ATOM   1989 C  CE1   . TYR A 1 631  ? 127.359 151.753 128.448 1.00 91.07  ? 976  TYR A CE1   1 
ATOM   1990 C  CE2   . TYR A 1 631  ? 127.697 151.493 126.097 1.00 90.73  ? 976  TYR A CE2   1 
ATOM   1991 C  CZ    . TYR A 1 631  ? 127.542 150.943 127.350 1.00 93.49  ? 976  TYR A CZ    1 
ATOM   1992 O  OH    . TYR A 1 631  ? 127.568 149.577 127.506 1.00 94.31  ? 976  TYR A OH    1 
ATOM   1993 N  N     . SER A 1 632  ? 129.952 155.153 129.260 1.00 99.95  ? 977  SER A N     1 
ATOM   1994 C  CA    . SER A 1 632  ? 130.182 155.051 130.697 1.00 101.09 ? 977  SER A CA    1 
ATOM   1995 C  C     . SER A 1 632  ? 130.551 156.399 131.303 1.00 100.35 ? 977  SER A C     1 
ATOM   1996 O  O     . SER A 1 632  ? 130.249 156.651 132.475 1.00 99.12  ? 977  SER A O     1 
ATOM   1997 C  CB    . SER A 1 632  ? 131.274 154.021 130.983 1.00 99.45  ? 977  SER A CB    1 
ATOM   1998 O  OG    . SER A 1 632  ? 131.013 152.800 130.311 1.00 98.40  ? 977  SER A OG    1 
ATOM   1999 N  N     . ASP A 1 633  ? 131.197 157.269 130.524 1.00 98.13  ? 978  ASP A N     1 
ATOM   2000 C  CA    . ASP A 1 633  ? 131.563 158.617 130.963 1.00 99.52  ? 978  ASP A CA    1 
ATOM   2001 C  C     . ASP A 1 633  ? 132.413 158.586 132.231 1.00 100.61 ? 978  ASP A C     1 
ATOM   2002 O  O     . ASP A 1 633  ? 132.258 159.418 133.127 1.00 100.35 ? 978  ASP A O     1 
ATOM   2003 C  CB    . ASP A 1 633  ? 130.323 159.491 131.159 1.00 99.95  ? 978  ASP A CB    1 
ATOM   2004 C  CG    . ASP A 1 633  ? 129.691 159.909 129.846 1.00 99.05  ? 978  ASP A CG    1 
ATOM   2005 O  OD1   . ASP A 1 633  ? 130.172 159.459 128.785 1.00 96.89  ? 978  ASP A OD1   1 
ATOM   2006 O  OD2   . ASP A 1 633  ? 128.716 160.689 129.874 1.00 98.57  ? 978  ASP A OD2   1 
ATOM   2007 N  N     . TYR A 1 634  ? 133.317 157.615 132.308 1.00 103.30 ? 979  TYR A N     1 
ATOM   2008 C  CA    . TYR A 1 634  ? 134.288 157.514 133.395 1.00 102.23 ? 979  TYR A CA    1 
ATOM   2009 C  C     . TYR A 1 634  ? 135.675 157.545 132.763 1.00 104.11 ? 979  TYR A C     1 
ATOM   2010 O  O     . TYR A 1 634  ? 136.131 156.544 132.201 1.00 102.95 ? 979  TYR A O     1 
ATOM   2011 C  CB    . TYR A 1 634  ? 134.075 156.247 134.216 1.00 100.03 ? 979  TYR A CB    1 
ATOM   2012 C  CG    . TYR A 1 634  ? 135.285 155.838 135.022 1.00 102.13 ? 979  TYR A CG    1 
ATOM   2013 C  CD1   . TYR A 1 634  ? 135.776 156.652 136.032 1.00 103.21 ? 979  TYR A CD1   1 
ATOM   2014 C  CD2   . TYR A 1 634  ? 135.942 154.643 134.768 1.00 103.77 ? 979  TYR A CD2   1 
ATOM   2015 C  CE1   . TYR A 1 634  ? 136.883 156.287 136.768 1.00 104.28 ? 979  TYR A CE1   1 
ATOM   2016 C  CE2   . TYR A 1 634  ? 137.050 154.268 135.501 1.00 102.41 ? 979  TYR A CE2   1 
ATOM   2017 C  CZ    . TYR A 1 634  ? 137.516 155.095 136.500 1.00 103.04 ? 979  TYR A CZ    1 
ATOM   2018 O  OH    . TYR A 1 634  ? 138.620 154.730 137.234 1.00 105.39 ? 979  TYR A OH    1 
ATOM   2019 N  N     . ILE A 1 635  ? 136.345 158.692 132.851 1.00 98.49  ? 980  ILE A N     1 
ATOM   2020 C  CA    . ILE A 1 635  ? 137.652 158.843 132.224 1.00 96.83  ? 980  ILE A CA    1 
ATOM   2021 C  C     . ILE A 1 635  ? 138.677 158.055 133.026 1.00 95.49  ? 980  ILE A C     1 
ATOM   2022 O  O     . ILE A 1 635  ? 138.858 158.285 134.228 1.00 95.24  ? 980  ILE A O     1 
ATOM   2023 C  CB    . ILE A 1 635  ? 138.044 160.322 132.117 1.00 96.80  ? 980  ILE A CB    1 
ATOM   2024 C  CG1   . ILE A 1 635  ? 137.055 161.077 131.225 1.00 95.19  ? 980  ILE A CG1   1 
ATOM   2025 C  CG2   . ILE A 1 635  ? 139.459 160.457 131.579 1.00 90.26  ? 980  ILE A CG2   1 
ATOM   2026 C  CD1   . ILE A 1 635  ? 136.649 160.326 129.972 1.00 95.12  ? 980  ILE A CD1   1 
ATOM   2027 N  N     . LYS A 1 636  ? 139.350 157.119 132.365 1.00 91.52  ? 981  LYS A N     1 
ATOM   2028 C  CA    . LYS A 1 636  ? 140.352 156.302 133.032 1.00 93.78  ? 981  LYS A CA    1 
ATOM   2029 C  C     . LYS A 1 636  ? 141.566 157.139 133.409 1.00 92.17  ? 981  LYS A C     1 
ATOM   2030 O  O     . LYS A 1 636  ? 142.034 157.971 132.627 1.00 91.12  ? 981  LYS A O     1 
ATOM   2031 C  CB    . LYS A 1 636  ? 140.780 155.146 132.131 1.00 91.08  ? 981  LYS A CB    1 
ATOM   2032 C  CG    . LYS A 1 636  ? 139.644 154.490 131.372 1.00 89.50  ? 981  LYS A CG    1 
ATOM   2033 C  CD    . LYS A 1 636  ? 139.003 153.403 132.209 1.00 87.69  ? 981  LYS A CD    1 
ATOM   2034 C  CE    . LYS A 1 636  ? 140.051 152.458 132.767 1.00 87.26  ? 981  LYS A CE    1 
ATOM   2035 N  NZ    . LYS A 1 636  ? 140.952 151.929 131.709 1.00 88.39  ? 981  LYS A NZ    1 
ATOM   2036 N  N     . GLY A 1 637  ? 142.077 156.911 134.615 1.00 75.27  ? 982  GLY A N     1 
ATOM   2037 C  CA    . GLY A 1 637  ? 143.280 157.581 135.061 1.00 71.15  ? 982  GLY A CA    1 
ATOM   2038 C  C     . GLY A 1 637  ? 143.171 159.091 135.070 1.00 76.49  ? 982  GLY A C     1 
ATOM   2039 O  O     . GLY A 1 637  ? 144.009 159.778 134.483 1.00 77.89  ? 982  GLY A O     1 
ATOM   2040 N  N     . SER A 1 638  ? 142.136 159.620 135.713 1.00 81.85  ? 983  SER A N     1 
ATOM   2041 C  CA    . SER A 1 638  ? 141.915 161.056 135.803 1.00 79.43  ? 983  SER A CA    1 
ATOM   2042 C  C     . SER A 1 638  ? 142.168 161.522 137.229 1.00 85.15  ? 983  SER A C     1 
ATOM   2043 O  O     . SER A 1 638  ? 141.657 160.925 138.182 1.00 87.56  ? 983  SER A O     1 
ATOM   2044 C  CB    . SER A 1 638  ? 140.493 161.421 135.371 1.00 80.88  ? 983  SER A CB    1 
ATOM   2045 O  OG    . SER A 1 638  ? 139.534 160.615 136.035 1.00 85.35  ? 983  SER A OG    1 
ATOM   2046 N  N     . ASN A 1 639  ? 142.955 162.586 137.371 1.00 79.97  ? 984  ASN A N     1 
ATOM   2047 C  CA    . ASN A 1 639  ? 143.239 163.185 138.666 1.00 79.34  ? 984  ASN A CA    1 
ATOM   2048 C  C     . ASN A 1 639  ? 142.314 164.350 138.983 1.00 77.34  ? 984  ASN A C     1 
ATOM   2049 O  O     . ASN A 1 639  ? 142.563 165.083 139.945 1.00 79.67  ? 984  ASN A O     1 
ATOM   2050 C  CB    . ASN A 1 639  ? 144.696 163.644 138.728 1.00 79.71  ? 984  ASN A CB    1 
ATOM   2051 C  CG    . ASN A 1 639  ? 145.568 162.710 139.539 1.00 79.41  ? 984  ASN A CG    1 
ATOM   2052 O  OD1   . ASN A 1 639  ? 145.090 161.722 140.095 1.00 76.90  ? 984  ASN A OD1   1 
ATOM   2053 N  ND2   . ASN A 1 639  ? 146.855 163.018 139.611 1.00 75.07  ? 984  ASN A ND2   1 
ATOM   2054 N  N     . LEU A 1 640  ? 141.258 164.542 138.189 1.00 85.17  ? 985  LEU A N     1 
ATOM   2055 C  CA    . LEU A 1 640  ? 140.341 165.653 138.424 1.00 86.21  ? 985  LEU A CA    1 
ATOM   2056 C  C     . LEU A 1 640  ? 139.633 165.515 139.767 1.00 90.31  ? 985  LEU A C     1 
ATOM   2057 O  O     . LEU A 1 640  ? 139.434 166.508 140.476 1.00 87.08  ? 985  LEU A O     1 
ATOM   2058 C  CB    . LEU A 1 640  ? 139.323 165.737 137.287 1.00 86.67  ? 985  LEU A CB    1 
ATOM   2059 C  CG    . LEU A 1 640  ? 138.464 167.000 137.214 1.00 88.46  ? 985  LEU A CG    1 
ATOM   2060 C  CD1   . LEU A 1 640  ? 138.393 167.516 135.786 1.00 86.92  ? 985  LEU A CD1   1 
ATOM   2061 C  CD2   . LEU A 1 640  ? 137.069 166.737 137.759 1.00 88.17  ? 985  LEU A CD2   1 
ATOM   2062 N  N     . ASP A 1 641  ? 139.246 164.296 140.132 1.00 93.14  ? 986  ASP A N     1 
ATOM   2063 C  CA    . ASP A 1 641  ? 138.483 164.052 141.348 1.00 93.53  ? 986  ASP A CA    1 
ATOM   2064 C  C     . ASP A 1 641  ? 139.359 163.716 142.549 1.00 88.76  ? 986  ASP A C     1 
ATOM   2065 O  O     . ASP A 1 641  ? 138.826 163.383 143.612 1.00 87.10  ? 986  ASP A O     1 
ATOM   2066 C  CB    . ASP A 1 641  ? 137.470 162.929 141.114 1.00 92.77  ? 986  ASP A CB    1 
ATOM   2067 C  CG    . ASP A 1 641  ? 136.116 163.451 140.676 1.00 91.12  ? 986  ASP A CG    1 
ATOM   2068 O  OD1   . ASP A 1 641  ? 136.078 164.367 139.828 1.00 88.45  ? 986  ASP A OD1   1 
ATOM   2069 O  OD2   . ASP A 1 641  ? 135.091 162.948 141.180 1.00 90.21  ? 986  ASP A OD2   1 
ATOM   2070 N  N     . ALA A 1 642  ? 140.678 163.789 142.408 1.00 78.46  ? 987  ALA A N     1 
ATOM   2071 C  CA    . ALA A 1 642  ? 141.555 163.500 143.531 1.00 76.62  ? 987  ALA A CA    1 
ATOM   2072 C  C     . ALA A 1 642  ? 141.387 164.560 144.618 1.00 74.82  ? 987  ALA A C     1 
ATOM   2073 O  O     . ALA A 1 642  ? 141.170 165.736 144.311 1.00 74.33  ? 987  ALA A O     1 
ATOM   2074 C  CB    . ALA A 1 642  ? 143.012 163.446 143.077 1.00 73.60  ? 987  ALA A CB    1 
ATOM   2075 N  N     . PRO A 1 643  ? 141.471 164.177 145.889 1.00 67.58  ? 988  PRO A N     1 
ATOM   2076 C  CA    . PRO A 1 643  ? 141.348 165.161 146.968 1.00 67.22  ? 988  PRO A CA    1 
ATOM   2077 C  C     . PRO A 1 643  ? 142.540 166.104 147.011 1.00 69.41  ? 988  PRO A C     1 
ATOM   2078 O  O     . PRO A 1 643  ? 143.631 165.803 146.526 1.00 73.72  ? 988  PRO A O     1 
ATOM   2079 C  CB    . PRO A 1 643  ? 141.283 164.298 148.233 1.00 63.84  ? 988  PRO A CB    1 
ATOM   2080 C  CG    . PRO A 1 643  ? 140.922 162.930 147.756 1.00 64.63  ? 988  PRO A CG    1 
ATOM   2081 C  CD    . PRO A 1 643  ? 141.540 162.802 146.404 1.00 66.07  ? 988  PRO A CD    1 
ATOM   2082 N  N     . GLU A 1 644  ? 142.306 167.276 147.597 1.00 62.53  ? 989  GLU A N     1 
ATOM   2083 C  CA    . GLU A 1 644  ? 143.379 168.233 147.799 1.00 62.09  ? 989  GLU A CA    1 
ATOM   2084 C  C     . GLU A 1 644  ? 144.257 167.808 148.974 1.00 64.23  ? 989  GLU A C     1 
ATOM   2085 O  O     . GLU A 1 644  ? 143.783 167.155 149.907 1.00 63.78  ? 989  GLU A O     1 
ATOM   2086 C  CB    . GLU A 1 644  ? 142.814 169.624 148.059 1.00 63.13  ? 989  GLU A CB    1 
ATOM   2087 C  CG    . GLU A 1 644  ? 141.619 169.977 147.198 1.00 70.15  ? 989  GLU A CG    1 
ATOM   2088 C  CD    . GLU A 1 644  ? 140.314 169.902 147.961 1.00 74.80  ? 989  GLU A CD    1 
ATOM   2089 O  OE1   . GLU A 1 644  ? 140.012 168.826 148.518 1.00 75.05  ? 989  GLU A OE1   1 
ATOM   2090 O  OE2   . GLU A 1 644  ? 139.589 170.918 148.003 1.00 76.13  ? 989  GLU A OE2   1 
ATOM   2091 N  N     . PRO A 1 645  ? 145.540 168.163 148.953 1.00 48.56  ? 990  PRO A N     1 
ATOM   2092 C  CA    . PRO A 1 645  ? 146.414 167.812 150.079 1.00 43.84  ? 990  PRO A CA    1 
ATOM   2093 C  C     . PRO A 1 645  ? 146.038 168.545 151.356 1.00 51.90  ? 990  PRO A C     1 
ATOM   2094 O  O     . PRO A 1 645  ? 145.129 169.380 151.358 1.00 55.72  ? 990  PRO A O     1 
ATOM   2095 C  CB    . PRO A 1 645  ? 147.807 168.219 149.585 1.00 34.77  ? 990  PRO A CB    1 
ATOM   2096 C  CG    . PRO A 1 645  ? 147.560 169.204 148.505 1.00 41.31  ? 990  PRO A CG    1 
ATOM   2097 C  CD    . PRO A 1 645  ? 146.286 168.787 147.850 1.00 46.41  ? 990  PRO A CD    1 
ATOM   2098 N  N     . TYR A 1 646  ? 146.736 168.238 152.446 1.00 55.63  ? 991  TYR A N     1 
ATOM   2099 C  CA    . TYR A 1 646  ? 146.423 168.831 153.738 1.00 37.23  ? 991  TYR A CA    1 
ATOM   2100 C  C     . TYR A 1 646  ? 146.630 170.338 153.707 1.00 39.21  ? 991  TYR A C     1 
ATOM   2101 O  O     . TYR A 1 646  ? 147.506 170.855 153.012 1.00 57.12  ? 991  TYR A O     1 
ATOM   2102 C  CB    . TYR A 1 646  ? 147.297 168.218 154.830 1.00 41.13  ? 991  TYR A CB    1 
ATOM   2103 C  CG    . TYR A 1 646  ? 146.724 166.974 155.456 1.00 44.00  ? 991  TYR A CG    1 
ATOM   2104 C  CD1   . TYR A 1 646  ? 145.362 166.731 155.436 1.00 47.44  ? 991  TYR A CD1   1 
ATOM   2105 C  CD2   . TYR A 1 646  ? 147.546 166.047 156.076 1.00 41.64  ? 991  TYR A CD2   1 
ATOM   2106 C  CE1   . TYR A 1 646  ? 144.834 165.596 156.011 1.00 53.39  ? 991  TYR A CE1   1 
ATOM   2107 C  CE2   . TYR A 1 646  ? 147.027 164.910 156.653 1.00 48.49  ? 991  TYR A CE2   1 
ATOM   2108 C  CZ    . TYR A 1 646  ? 145.670 164.689 156.617 1.00 53.83  ? 991  TYR A CZ    1 
ATOM   2109 O  OH    . TYR A 1 646  ? 145.146 163.556 157.193 1.00 55.12  ? 991  TYR A OH    1 
ATOM   2110 N  N     . ARG A 1 647  ? 145.803 171.047 154.468 1.00 35.95  ? 992  ARG A N     1 
ATOM   2111 C  CA    . ARG A 1 647  ? 145.980 172.480 154.667 1.00 43.00  ? 992  ARG A CA    1 
ATOM   2112 C  C     . ARG A 1 647  ? 147.061 172.681 155.721 1.00 50.08  ? 992  ARG A C     1 
ATOM   2113 O  O     . ARG A 1 647  ? 146.841 172.409 156.902 1.00 65.12  ? 992  ARG A O     1 
ATOM   2114 C  CB    . ARG A 1 647  ? 144.668 173.129 155.095 1.00 42.11  ? 992  ARG A CB    1 
ATOM   2115 C  CG    . ARG A 1 647  ? 143.648 173.276 153.985 1.00 50.16  ? 992  ARG A CG    1 
ATOM   2116 C  CD    . ARG A 1 647  ? 144.037 174.384 153.026 1.00 51.42  ? 992  ARG A CD    1 
ATOM   2117 N  NE    . ARG A 1 647  ? 142.921 174.784 152.178 1.00 50.13  ? 992  ARG A NE    1 
ATOM   2118 C  CZ    . ARG A 1 647  ? 142.587 174.183 151.046 1.00 48.59  ? 992  ARG A CZ    1 
ATOM   2119 N  NH1   . ARG A 1 647  ? 143.266 173.145 150.588 1.00 50.60  ? 992  ARG A NH1   1 
ATOM   2120 N  NH2   . ARG A 1 647  ? 141.545 174.634 150.355 1.00 50.81  ? 992  ARG A NH2   1 
ATOM   2121 N  N     . ILE A 1 648  ? 148.229 173.122 155.302 1.00 35.28  ? 993  ILE A N     1 
ATOM   2122 C  CA    . ILE A 1 648  ? 149.315 173.355 156.243 1.00 23.34  ? 993  ILE A CA    1 
ATOM   2123 C  C     . ILE A 1 648  ? 149.068 174.667 156.968 1.00 31.64  ? 993  ILE A C     1 
ATOM   2124 O  O     . ILE A 1 648  ? 148.433 175.582 156.438 1.00 55.56  ? 993  ILE A O     1 
ATOM   2125 C  CB    . ILE A 1 648  ? 150.671 173.355 155.513 1.00 30.21  ? 993  ILE A CB    1 
ATOM   2126 C  CG1   . ILE A 1 648  ? 150.677 172.295 154.415 1.00 42.73  ? 993  ILE A CG1   1 
ATOM   2127 C  CG2   . ILE A 1 648  ? 151.800 173.099 156.483 1.00 41.79  ? 993  ILE A CG2   1 
ATOM   2128 C  CD1   . ILE A 1 648  ? 150.595 170.884 154.932 1.00 39.39  ? 993  ILE A CD1   1 
ATOM   2129 N  N     . GLY A 1 649  ? 149.553 174.761 158.201 1.00 23.02  ? 994  GLY A N     1 
ATOM   2130 C  CA    . GLY A 1 649  ? 149.446 176.026 158.904 1.00 32.23  ? 994  GLY A CA    1 
ATOM   2131 C  C     . GLY A 1 649  ? 150.422 176.094 160.054 1.00 40.52  ? 994  GLY A C     1 
ATOM   2132 O  O     . GLY A 1 649  ? 151.009 175.089 160.457 1.00 51.69  ? 994  GLY A O     1 
ATOM   2133 N  N     . ARG A 1 650  ? 150.592 177.301 160.587 1.00 41.53  ? 995  ARG A N     1 
ATOM   2134 C  CA    . ARG A 1 650  ? 151.462 177.523 161.735 1.00 42.28  ? 995  ARG A CA    1 
ATOM   2135 C  C     . ARG A 1 650  ? 150.643 178.057 162.900 1.00 47.97  ? 995  ARG A C     1 
ATOM   2136 O  O     . ARG A 1 650  ? 149.969 179.079 162.768 1.00 54.76  ? 995  ARG A O     1 
ATOM   2137 C  CB    . ARG A 1 650  ? 152.589 178.499 161.399 1.00 48.15  ? 995  ARG A CB    1 
ATOM   2138 C  CG    . ARG A 1 650  ? 153.183 179.179 162.615 1.00 45.93  ? 995  ARG A CG    1 
ATOM   2139 C  CD    . ARG A 1 650  ? 154.383 180.025 162.246 1.00 47.41  ? 995  ARG A CD    1 
ATOM   2140 N  NE    . ARG A 1 650  ? 155.511 179.209 161.818 1.00 48.06  ? 995  ARG A NE    1 
ATOM   2141 C  CZ    . ARG A 1 650  ? 156.682 179.696 161.435 1.00 48.64  ? 995  ARG A CZ    1 
ATOM   2142 N  NH1   . ARG A 1 650  ? 156.916 180.997 161.418 1.00 54.17  ? 995  ARG A NH1   1 
ATOM   2143 N  NH2   . ARG A 1 650  ? 157.642 178.857 161.060 1.00 46.12  ? 995  ARG A NH2   1 
ATOM   2144 N  N     . ILE A 1 651  ? 150.716 177.379 164.044 1.00 49.90  ? 996  ILE A N     1 
ATOM   2145 C  CA    . ILE A 1 651  ? 149.952 177.805 165.210 1.00 47.51  ? 996  ILE A CA    1 
ATOM   2146 C  C     . ILE A 1 651  ? 150.522 179.112 165.743 1.00 52.72  ? 996  ILE A C     1 
ATOM   2147 O  O     . ILE A 1 651  ? 151.730 179.229 165.982 1.00 64.67  ? 996  ILE A O     1 
ATOM   2148 C  CB    . ILE A 1 651  ? 149.968 176.716 166.291 1.00 43.17  ? 996  ILE A CB    1 
ATOM   2149 C  CG1   . ILE A 1 651  ? 149.225 175.471 165.817 1.00 40.21  ? 996  ILE A CG1   1 
ATOM   2150 C  CG2   . ILE A 1 651  ? 149.346 177.237 167.562 1.00 48.65  ? 996  ILE A CG2   1 
ATOM   2151 C  CD1   . ILE A 1 651  ? 149.035 174.444 166.903 1.00 43.00  ? 996  ILE A CD1   1 
ATOM   2152 N  N     . LYS A 1 652  ? 149.654 180.105 165.933 1.00 49.12  ? 997  LYS A N     1 
ATOM   2153 C  CA    . LYS A 1 652  ? 150.031 181.398 166.487 1.00 56.22  ? 997  LYS A CA    1 
ATOM   2154 C  C     . LYS A 1 652  ? 149.711 181.518 167.970 1.00 65.70  ? 997  LYS A C     1 
ATOM   2155 O  O     . LYS A 1 652  ? 150.505 182.088 168.724 1.00 76.13  ? 997  LYS A O     1 
ATOM   2156 C  CB    . LYS A 1 652  ? 149.327 182.523 165.723 1.00 57.49  ? 997  LYS A CB    1 
ATOM   2157 C  CG    . LYS A 1 652  ? 149.713 183.921 166.172 1.00 58.87  ? 997  LYS A CG    1 
ATOM   2158 C  CD    . LYS A 1 652  ? 148.614 184.921 165.860 1.00 61.07  ? 997  LYS A CD    1 
ATOM   2159 C  CE    . LYS A 1 652  ? 148.939 185.731 164.620 1.00 64.03  ? 997  LYS A CE    1 
ATOM   2160 N  NZ    . LYS A 1 652  ? 149.991 186.748 164.889 1.00 64.41  ? 997  LYS A NZ    1 
ATOM   2161 N  N     . GLU A 1 653  ? 148.563 181.003 168.404 1.00 74.36  ? 998  GLU A N     1 
ATOM   2162 C  CA    . GLU A 1 653  ? 148.215 181.003 169.818 1.00 75.70  ? 998  GLU A CA    1 
ATOM   2163 C  C     . GLU A 1 653  ? 147.208 179.894 170.078 1.00 76.67  ? 998  GLU A C     1 
ATOM   2164 O  O     . GLU A 1 653  ? 146.490 179.458 169.176 1.00 79.78  ? 998  GLU A O     1 
ATOM   2165 C  CB    . GLU A 1 653  ? 147.649 182.355 170.264 1.00 74.06  ? 998  GLU A CB    1 
ATOM   2166 C  CG    . GLU A 1 653  ? 146.239 182.632 169.776 1.00 78.76  ? 998  GLU A CG    1 
ATOM   2167 C  CD    . GLU A 1 653  ? 145.719 183.980 170.235 1.00 85.72  ? 998  GLU A CD    1 
ATOM   2168 O  OE1   . GLU A 1 653  ? 146.543 184.889 170.469 1.00 87.84  ? 998  GLU A OE1   1 
ATOM   2169 O  OE2   . GLU A 1 653  ? 144.486 184.133 170.363 1.00 83.97  ? 998  GLU A OE2   1 
ATOM   2170 N  N     . ILE A 1 654  ? 147.172 179.442 171.327 1.00 75.53  ? 999  ILE A N     1 
ATOM   2171 C  CA    . ILE A 1 654  ? 146.206 178.454 171.791 1.00 77.27  ? 999  ILE A CA    1 
ATOM   2172 C  C     . ILE A 1 654  ? 145.386 179.105 172.894 1.00 81.47  ? 999  ILE A C     1 
ATOM   2173 O  O     . ILE A 1 654  ? 145.945 179.566 173.897 1.00 83.24  ? 999  ILE A O     1 
ATOM   2174 C  CB    . ILE A 1 654  ? 146.889 177.177 172.303 1.00 77.36  ? 999  ILE A CB    1 
ATOM   2175 C  CG1   . ILE A 1 654  ? 147.705 176.524 171.192 1.00 73.68  ? 999  ILE A CG1   1 
ATOM   2176 C  CG2   . ILE A 1 654  ? 145.854 176.199 172.822 1.00 81.08  ? 999  ILE A CG2   1 
ATOM   2177 C  CD1   . ILE A 1 654  ? 146.893 176.189 169.978 1.00 76.39  ? 999  ILE A CD1   1 
ATOM   2178 N  N     . PHE A 1 655  ? 144.069 179.144 172.716 1.00 90.98  ? 1000 PHE A N     1 
ATOM   2179 C  CA    . PHE A 1 655  ? 143.204 179.776 173.698 1.00 90.28  ? 1000 PHE A CA    1 
ATOM   2180 C  C     . PHE A 1 655  ? 141.982 178.905 173.937 1.00 92.49  ? 1000 PHE A C     1 
ATOM   2181 O  O     . PHE A 1 655  ? 141.579 178.108 173.087 1.00 90.38  ? 1000 PHE A O     1 
ATOM   2182 C  CB    . PHE A 1 655  ? 142.780 181.190 173.265 1.00 91.10  ? 1000 PHE A CB    1 
ATOM   2183 C  CG    . PHE A 1 655  ? 142.045 181.241 171.954 1.00 88.53  ? 1000 PHE A CG    1 
ATOM   2184 C  CD1   . PHE A 1 655  ? 140.691 180.956 171.888 1.00 87.62  ? 1000 PHE A CD1   1 
ATOM   2185 C  CD2   . PHE A 1 655  ? 142.706 181.582 170.791 1.00 91.90  ? 1000 PHE A CD2   1 
ATOM   2186 C  CE1   . PHE A 1 655  ? 140.015 181.006 170.689 1.00 88.75  ? 1000 PHE A CE1   1 
ATOM   2187 C  CE2   . PHE A 1 655  ? 142.034 181.632 169.587 1.00 93.29  ? 1000 PHE A CE2   1 
ATOM   2188 C  CZ    . PHE A 1 655  ? 140.687 181.343 169.536 1.00 92.03  ? 1000 PHE A CZ    1 
ATOM   2189 N  N     . CYS A 1 656  ? 141.401 179.072 175.121 1.00 101.63 ? 1001 CYS A N     1 
ATOM   2190 C  CA    . CYS A 1 656  ? 140.165 178.413 175.495 1.00 101.71 ? 1001 CYS A CA    1 
ATOM   2191 C  C     . CYS A 1 656  ? 139.131 179.447 175.917 1.00 100.66 ? 1001 CYS A C     1 
ATOM   2192 O  O     . CYS A 1 656  ? 139.459 180.380 176.658 1.00 99.49  ? 1001 CYS A O     1 
ATOM   2193 C  CB    . CYS A 1 656  ? 140.385 177.432 176.647 1.00 102.29 ? 1001 CYS A CB    1 
ATOM   2194 S  SG    . CYS A 1 656  ? 141.999 176.667 176.639 1.00 106.25 ? 1001 CYS A SG    1 
ATOM   2195 N  N     . PRO A 1 657  ? 137.882 179.308 175.472 1.00 106.56 ? 1002 PRO A N     1 
ATOM   2196 C  CA    . PRO A 1 657  ? 136.836 180.261 175.867 1.00 105.75 ? 1002 PRO A CA    1 
ATOM   2197 C  C     . PRO A 1 657  ? 136.411 180.016 177.306 1.00 106.76 ? 1002 PRO A C     1 
ATOM   2198 O  O     . PRO A 1 657  ? 136.182 178.875 177.712 1.00 107.65 ? 1002 PRO A O     1 
ATOM   2199 C  CB    . PRO A 1 657  ? 135.695 179.970 174.882 1.00 107.20 ? 1002 PRO A CB    1 
ATOM   2200 C  CG    . PRO A 1 657  ? 136.263 179.004 173.865 1.00 107.83 ? 1002 PRO A CG    1 
ATOM   2201 C  CD    . PRO A 1 657  ? 137.364 178.281 174.558 1.00 107.88 ? 1002 PRO A CD    1 
ATOM   2202 N  N     . LYS A 1 658  ? 136.307 181.093 178.077 1.00 123.21 ? 1003 LYS A N     1 
ATOM   2203 C  CA    . LYS A 1 658  ? 135.903 180.975 179.470 1.00 126.31 ? 1003 LYS A CA    1 
ATOM   2204 C  C     . LYS A 1 658  ? 134.440 180.560 179.568 1.00 126.37 ? 1003 LYS A C     1 
ATOM   2205 O  O     . LYS A 1 658  ? 133.587 181.043 178.819 1.00 124.97 ? 1003 LYS A O     1 
ATOM   2206 C  CB    . LYS A 1 658  ? 136.128 182.297 180.200 1.00 126.20 ? 1003 LYS A CB    1 
ATOM   2207 C  CG    . LYS A 1 658  ? 137.586 182.710 180.280 1.00 124.24 ? 1003 LYS A CG    1 
ATOM   2208 C  CD    . LYS A 1 658  ? 137.779 183.866 181.244 1.00 123.83 ? 1003 LYS A CD    1 
ATOM   2209 C  CE    . LYS A 1 658  ? 137.388 183.471 182.656 1.00 124.53 ? 1003 LYS A CE    1 
ATOM   2210 N  NZ    . LYS A 1 658  ? 138.120 182.256 183.107 1.00 125.87 ? 1003 LYS A NZ    1 
ATOM   2211 N  N     . LYS A 1 659  ? 134.155 179.655 180.500 1.00 134.72 ? 1004 LYS A N     1 
ATOM   2212 C  CA    . LYS A 1 659  ? 132.798 179.180 180.716 1.00 134.72 ? 1004 LYS A CA    1 
ATOM   2213 C  C     . LYS A 1 659  ? 132.010 180.194 181.543 1.00 136.33 ? 1004 LYS A C     1 
ATOM   2214 O  O     . LYS A 1 659  ? 132.520 181.243 181.948 1.00 135.41 ? 1004 LYS A O     1 
ATOM   2215 C  CB    . LYS A 1 659  ? 132.819 177.811 181.391 1.00 134.04 ? 1004 LYS A CB    1 
ATOM   2216 C  CG    . LYS A 1 659  ? 132.581 176.648 180.443 1.00 132.98 ? 1004 LYS A CG    1 
ATOM   2217 C  CD    . LYS A 1 659  ? 132.662 175.317 181.174 1.00 134.06 ? 1004 LYS A CD    1 
ATOM   2218 C  CE    . LYS A 1 659  ? 131.685 175.261 182.335 1.00 136.06 ? 1004 LYS A CE    1 
ATOM   2219 N  NZ    . LYS A 1 659  ? 131.799 173.984 183.093 1.00 135.20 ? 1004 LYS A NZ    1 
ATOM   2220 N  N     . SER A 1 660  ? 130.739 179.875 181.800 1.00 143.14 ? 1005 SER A N     1 
ATOM   2221 C  CA    . SER A 1 660  ? 129.886 180.772 182.570 1.00 141.80 ? 1005 SER A CA    1 
ATOM   2222 C  C     . SER A 1 660  ? 130.313 180.873 184.028 1.00 141.58 ? 1005 SER A C     1 
ATOM   2223 O  O     . SER A 1 660  ? 129.933 181.834 184.705 1.00 141.13 ? 1005 SER A O     1 
ATOM   2224 C  CB    . SER A 1 660  ? 128.430 180.314 182.486 1.00 141.51 ? 1005 SER A CB    1 
ATOM   2225 O  OG    . SER A 1 660  ? 127.592 181.133 183.283 1.00 141.45 ? 1005 SER A OG    1 
ATOM   2226 N  N     . ASN A 1 661  ? 131.089 179.913 184.524 1.00 139.93 ? 1006 ASN A N     1 
ATOM   2227 C  CA    . ASN A 1 661  ? 131.554 179.918 185.903 1.00 139.74 ? 1006 ASN A CA    1 
ATOM   2228 C  C     . ASN A 1 661  ? 132.880 180.648 186.075 1.00 140.44 ? 1006 ASN A C     1 
ATOM   2229 O  O     . ASN A 1 661  ? 133.453 180.619 187.169 1.00 139.88 ? 1006 ASN A O     1 
ATOM   2230 C  CB    . ASN A 1 661  ? 131.677 178.483 186.424 1.00 139.60 ? 1006 ASN A CB    1 
ATOM   2231 C  CG    . ASN A 1 661  ? 132.390 177.565 185.451 1.00 139.08 ? 1006 ASN A CG    1 
ATOM   2232 O  OD1   . ASN A 1 661  ? 133.155 178.017 184.599 1.00 138.64 ? 1006 ASN A OD1   1 
ATOM   2233 N  ND2   . ASN A 1 661  ? 132.141 176.267 185.572 1.00 139.60 ? 1006 ASN A ND2   1 
ATOM   2234 N  N     . GLY A 1 662  ? 133.380 181.295 185.025 1.00 138.29 ? 1007 GLY A N     1 
ATOM   2235 C  CA    . GLY A 1 662  ? 134.638 182.005 185.116 1.00 137.77 ? 1007 GLY A CA    1 
ATOM   2236 C  C     . GLY A 1 662  ? 135.868 181.132 185.082 1.00 137.41 ? 1007 GLY A C     1 
ATOM   2237 O  O     . GLY A 1 662  ? 136.935 181.567 185.526 1.00 138.29 ? 1007 GLY A O     1 
ATOM   2238 N  N     . ARG A 1 663  ? 135.757 179.912 184.568 1.00 135.56 ? 1008 ARG A N     1 
ATOM   2239 C  CA    . ARG A 1 663  ? 136.882 178.997 184.477 1.00 136.19 ? 1008 ARG A CA    1 
ATOM   2240 C  C     . ARG A 1 663  ? 137.019 178.483 183.053 1.00 136.26 ? 1008 ARG A C     1 
ATOM   2241 O  O     . ARG A 1 663  ? 136.028 178.396 182.320 1.00 135.77 ? 1008 ARG A O     1 
ATOM   2242 C  CB    . ARG A 1 663  ? 136.714 177.813 185.439 1.00 135.98 ? 1008 ARG A CB    1 
ATOM   2243 C  CG    . ARG A 1 663  ? 137.208 178.090 186.849 1.00 136.11 ? 1008 ARG A CG    1 
ATOM   2244 C  CD    . ARG A 1 663  ? 136.537 177.181 187.864 1.00 136.31 ? 1008 ARG A CD    1 
ATOM   2245 N  NE    . ARG A 1 663  ? 136.793 175.773 187.590 1.00 138.13 ? 1008 ARG A NE    1 
ATOM   2246 C  CZ    . ARG A 1 663  ? 135.870 174.907 187.197 1.00 138.65 ? 1008 ARG A CZ    1 
ATOM   2247 N  NH1   . ARG A 1 663  ? 134.610 175.272 187.021 1.00 138.37 ? 1008 ARG A NH1   1 
ATOM   2248 N  NH2   . ARG A 1 663  ? 136.218 173.642 186.975 1.00 138.29 ? 1008 ARG A NH2   1 
ATOM   2249 N  N     . PRO A 1 664  ? 138.237 178.144 182.633 1.00 126.49 ? 1009 PRO A N     1 
ATOM   2250 C  CA    . PRO A 1 664  ? 138.435 177.640 181.272 1.00 124.24 ? 1009 PRO A CA    1 
ATOM   2251 C  C     . PRO A 1 664  ? 137.710 176.326 181.035 1.00 125.50 ? 1009 PRO A C     1 
ATOM   2252 O  O     . PRO A 1 664  ? 137.536 175.511 181.943 1.00 125.20 ? 1009 PRO A O     1 
ATOM   2253 C  CB    . PRO A 1 664  ? 139.957 177.460 181.199 1.00 122.36 ? 1009 PRO A CB    1 
ATOM   2254 C  CG    . PRO A 1 664  ? 140.311 177.182 182.636 1.00 125.16 ? 1009 PRO A CG    1 
ATOM   2255 C  CD    . PRO A 1 664  ? 139.537 178.276 183.308 1.00 126.36 ? 1009 PRO A CD    1 
ATOM   2256 N  N     . ASN A 1 665  ? 137.281 176.132 179.792 1.00 115.83 ? 1010 ASN A N     1 
ATOM   2257 C  CA    . ASN A 1 665  ? 136.651 174.893 179.356 1.00 114.26 ? 1010 ASN A CA    1 
ATOM   2258 C  C     . ASN A 1 665  ? 137.699 174.057 178.632 1.00 112.22 ? 1010 ASN A C     1 
ATOM   2259 O  O     . ASN A 1 665  ? 138.075 174.367 177.497 1.00 111.40 ? 1010 ASN A O     1 
ATOM   2260 C  CB    . ASN A 1 665  ? 135.455 175.180 178.452 1.00 112.68 ? 1010 ASN A CB    1 
ATOM   2261 C  CG    . ASN A 1 665  ? 134.738 173.921 178.023 1.00 113.19 ? 1010 ASN A CG    1 
ATOM   2262 O  OD1   . ASN A 1 665  ? 134.879 172.869 178.644 1.00 113.59 ? 1010 ASN A OD1   1 
ATOM   2263 N  ND2   . ASN A 1 665  ? 133.960 174.020 176.951 1.00 114.09 ? 1010 ASN A ND2   1 
ATOM   2264 N  N     . GLU A 1 666  ? 138.166 172.993 179.285 1.00 113.21 ? 1011 GLU A N     1 
ATOM   2265 C  CA    . GLU A 1 666  ? 139.223 172.149 178.747 1.00 114.76 ? 1011 GLU A CA    1 
ATOM   2266 C  C     . GLU A 1 666  ? 138.695 171.056 177.826 1.00 113.19 ? 1011 GLU A C     1 
ATOM   2267 O  O     . GLU A 1 666  ? 139.408 170.082 177.562 1.00 111.27 ? 1011 GLU A O     1 
ATOM   2268 C  CB    . GLU A 1 666  ? 140.031 171.528 179.889 1.00 113.85 ? 1011 GLU A CB    1 
ATOM   2269 C  CG    . GLU A 1 666  ? 140.777 172.540 180.744 1.00 113.99 ? 1011 GLU A CG    1 
ATOM   2270 C  CD    . GLU A 1 666  ? 141.789 173.343 179.951 1.00 116.22 ? 1011 GLU A CD    1 
ATOM   2271 O  OE1   . GLU A 1 666  ? 142.831 172.774 179.563 1.00 114.82 ? 1011 GLU A OE1   1 
ATOM   2272 O  OE2   . GLU A 1 666  ? 141.542 174.544 179.714 1.00 115.82 ? 1011 GLU A OE2   1 
ATOM   2273 N  N     . THR A 1 667  ? 137.467 171.194 177.332 1.00 111.39 ? 1012 THR A N     1 
ATOM   2274 C  CA    . THR A 1 667  ? 136.895 170.233 176.398 1.00 111.90 ? 1012 THR A CA    1 
ATOM   2275 C  C     . THR A 1 667  ? 137.010 170.680 174.949 1.00 110.59 ? 1012 THR A C     1 
ATOM   2276 O  O     . THR A 1 667  ? 137.364 169.873 174.084 1.00 112.46 ? 1012 THR A O     1 
ATOM   2277 C  CB    . THR A 1 667  ? 135.423 169.974 176.735 1.00 112.60 ? 1012 THR A CB    1 
ATOM   2278 O  OG1   . THR A 1 667  ? 134.654 171.152 176.464 1.00 113.51 ? 1012 THR A OG1   1 
ATOM   2279 C  CG2   . THR A 1 667  ? 135.271 169.601 178.201 1.00 111.68 ? 1012 THR A CG2   1 
ATOM   2280 N  N     . ASP A 1 668  ? 136.725 171.948 174.661 1.00 99.70  ? 1013 ASP A N     1 
ATOM   2281 C  CA    . ASP A 1 668  ? 136.890 172.515 173.327 1.00 98.51  ? 1013 ASP A CA    1 
ATOM   2282 C  C     . ASP A 1 668  ? 138.137 173.388 173.347 1.00 98.65  ? 1013 ASP A C     1 
ATOM   2283 O  O     . ASP A 1 668  ? 138.266 174.278 174.194 1.00 99.63  ? 1013 ASP A O     1 
ATOM   2284 C  CB    . ASP A 1 668  ? 135.663 173.322 172.906 1.00 99.60  ? 1013 ASP A CB    1 
ATOM   2285 C  CG    . ASP A 1 668  ? 135.331 174.431 173.881 1.00 103.26 ? 1013 ASP A CG    1 
ATOM   2286 O  OD1   . ASP A 1 668  ? 135.616 174.272 175.085 1.00 104.19 ? 1013 ASP A OD1   1 
ATOM   2287 O  OD2   . ASP A 1 668  ? 134.793 175.468 173.439 1.00 102.86 ? 1013 ASP A OD2   1 
ATOM   2288 N  N     . ILE A 1 669  ? 139.061 173.126 172.429 1.00 84.30  ? 1014 ILE A N     1 
ATOM   2289 C  CA    . ILE A 1 669  ? 140.306 173.875 172.339 1.00 81.13  ? 1014 ILE A CA    1 
ATOM   2290 C  C     . ILE A 1 669  ? 140.360 174.501 170.955 1.00 84.31  ? 1014 ILE A C     1 
ATOM   2291 O  O     . ILE A 1 669  ? 140.323 173.790 169.944 1.00 84.49  ? 1014 ILE A O     1 
ATOM   2292 C  CB    . ILE A 1 669  ? 141.525 172.977 172.586 1.00 80.67  ? 1014 ILE A CB    1 
ATOM   2293 C  CG1   . ILE A 1 669  ? 141.589 172.582 174.055 1.00 82.05  ? 1014 ILE A CG1   1 
ATOM   2294 C  CG2   . ILE A 1 669  ? 142.795 173.717 172.224 1.00 80.54  ? 1014 ILE A CG2   1 
ATOM   2295 C  CD1   . ILE A 1 669  ? 141.507 173.738 174.986 1.00 84.36  ? 1014 ILE A CD1   1 
ATOM   2296 N  N     . LYS A 1 670  ? 140.446 175.825 170.906 1.00 77.12  ? 1015 LYS A N     1 
ATOM   2297 C  CA    . LYS A 1 670  ? 140.421 176.566 169.652 1.00 77.73  ? 1015 LYS A CA    1 
ATOM   2298 C  C     . LYS A 1 670  ? 141.817 177.094 169.363 1.00 78.85  ? 1015 LYS A C     1 
ATOM   2299 O  O     . LYS A 1 670  ? 142.386 177.825 170.179 1.00 79.59  ? 1015 LYS A O     1 
ATOM   2300 C  CB    . LYS A 1 670  ? 139.413 177.712 169.718 1.00 77.08  ? 1015 LYS A CB    1 
ATOM   2301 C  CG    . LYS A 1 670  ? 138.117 177.428 168.985 1.00 78.09  ? 1015 LYS A CG    1 
ATOM   2302 C  CD    . LYS A 1 670  ? 137.169 176.609 169.839 1.00 77.59  ? 1015 LYS A CD    1 
ATOM   2303 C  CE    . LYS A 1 670  ? 135.733 176.788 169.385 1.00 78.52  ? 1015 LYS A CE    1 
ATOM   2304 N  NZ    . LYS A 1 670  ? 135.572 176.472 167.941 1.00 76.68  ? 1015 LYS A NZ    1 
ATOM   2305 N  N     . ILE A 1 671  ? 142.362 176.724 168.207 1.00 68.43  ? 1016 ILE A N     1 
ATOM   2306 C  CA    . ILE A 1 671  ? 143.678 177.166 167.771 1.00 59.45  ? 1016 ILE A CA    1 
ATOM   2307 C  C     . ILE A 1 671  ? 143.501 178.278 166.751 1.00 64.27  ? 1016 ILE A C     1 
ATOM   2308 O  O     . ILE A 1 671  ? 142.556 178.267 165.949 1.00 70.57  ? 1016 ILE A O     1 
ATOM   2309 C  CB    . ILE A 1 671  ? 144.493 175.996 167.185 1.00 51.44  ? 1016 ILE A CB    1 
ATOM   2310 C  CG1   . ILE A 1 671  ? 144.090 175.709 165.742 1.00 57.67  ? 1016 ILE A CG1   1 
ATOM   2311 C  CG2   . ILE A 1 671  ? 144.262 174.745 167.991 1.00 58.42  ? 1016 ILE A CG2   1 
ATOM   2312 C  CD1   . ILE A 1 671  ? 144.932 174.654 165.079 1.00 63.23  ? 1016 ILE A CD1   1 
ATOM   2313 N  N     . ARG A 1 672  ? 144.387 179.263 166.808 1.00 62.28  ? 1017 ARG A N     1 
ATOM   2314 C  CA    . ARG A 1 672  ? 144.488 180.303 165.797 1.00 59.22  ? 1017 ARG A CA    1 
ATOM   2315 C  C     . ARG A 1 672  ? 145.742 180.013 164.989 1.00 65.87  ? 1017 ARG A C     1 
ATOM   2316 O  O     . ARG A 1 672  ? 146.827 179.870 165.558 1.00 72.82  ? 1017 ARG A O     1 
ATOM   2317 C  CB    . ARG A 1 672  ? 144.550 181.687 166.439 1.00 59.37  ? 1017 ARG A CB    1 
ATOM   2318 C  CG    . ARG A 1 672  ? 144.363 182.836 165.473 1.00 62.27  ? 1017 ARG A CG    1 
ATOM   2319 C  CD    . ARG A 1 672  ? 144.486 184.171 166.186 1.00 62.41  ? 1017 ARG A CD    1 
ATOM   2320 N  NE    . ARG A 1 672  ? 143.630 185.186 165.588 1.00 66.05  ? 1017 ARG A NE    1 
ATOM   2321 C  CZ    . ARG A 1 672  ? 142.320 185.265 165.775 1.00 67.49  ? 1017 ARG A CZ    1 
ATOM   2322 N  NH1   . ARG A 1 672  ? 141.680 184.412 166.557 1.00 65.84  ? 1017 ARG A NH1   1 
ATOM   2323 N  NH2   . ARG A 1 672  ? 141.634 186.227 165.163 1.00 66.56  ? 1017 ARG A NH2   1 
ATOM   2324 N  N     . VAL A 1 673  ? 145.592 179.896 163.675 1.00 48.47  ? 1018 VAL A N     1 
ATOM   2325 C  CA    . VAL A 1 673  ? 146.658 179.404 162.813 1.00 36.39  ? 1018 VAL A CA    1 
ATOM   2326 C  C     . VAL A 1 673  ? 146.858 180.370 161.657 1.00 47.63  ? 1018 VAL A C     1 
ATOM   2327 O  O     . VAL A 1 673  ? 145.890 180.786 161.013 1.00 56.31  ? 1018 VAL A O     1 
ATOM   2328 C  CB    . VAL A 1 673  ? 146.357 177.984 162.298 1.00 33.36  ? 1018 VAL A CB    1 
ATOM   2329 C  CG1   . VAL A 1 673  ? 144.977 177.915 161.688 1.00 43.81  ? 1018 VAL A CG1   1 
ATOM   2330 C  CG2   . VAL A 1 673  ? 147.383 177.573 161.283 1.00 42.38  ? 1018 VAL A CG2   1 
ATOM   2331 N  N     . ASN A 1 674  ? 148.111 180.746 161.416 1.00 57.09  ? 1019 ASN A N     1 
ATOM   2332 C  CA    . ASN A 1 674  ? 148.485 181.468 160.212 1.00 54.25  ? 1019 ASN A CA    1 
ATOM   2333 C  C     . ASN A 1 674  ? 148.522 180.505 159.034 1.00 54.64  ? 1019 ASN A C     1 
ATOM   2334 O  O     . ASN A 1 674  ? 149.104 179.417 159.127 1.00 63.87  ? 1019 ASN A O     1 
ATOM   2335 C  CB    . ASN A 1 674  ? 149.844 182.140 160.392 1.00 42.95  ? 1019 ASN A CB    1 
ATOM   2336 C  CG    . ASN A 1 674  ? 149.726 183.529 160.963 1.00 55.74  ? 1019 ASN A CG    1 
ATOM   2337 O  OD1   . ASN A 1 674  ? 148.637 183.972 161.319 1.00 65.13  ? 1019 ASN A OD1   1 
ATOM   2338 N  ND2   . ASN A 1 674  ? 150.847 184.226 161.060 1.00 53.68  ? 1019 ASN A ND2   1 
ATOM   2339 N  N     . LYS A 1 675  ? 147.897 180.910 157.933 1.00 43.56  ? 1020 LYS A N     1 
ATOM   2340 C  CA    . LYS A 1 675  ? 147.765 180.073 156.755 1.00 42.43  ? 1020 LYS A CA    1 
ATOM   2341 C  C     . LYS A 1 675  ? 149.081 179.998 155.992 1.00 48.63  ? 1020 LYS A C     1 
ATOM   2342 O  O     . LYS A 1 675  ? 149.955 180.858 156.115 1.00 60.68  ? 1020 LYS A O     1 
ATOM   2343 C  CB    . LYS A 1 675  ? 146.669 180.610 155.839 1.00 47.33  ? 1020 LYS A CB    1 
ATOM   2344 C  CG    . LYS A 1 675  ? 145.322 180.760 156.510 1.00 50.28  ? 1020 LYS A CG    1 
ATOM   2345 C  CD    . LYS A 1 675  ? 144.341 181.483 155.611 1.00 52.16  ? 1020 LYS A CD    1 
ATOM   2346 C  CE    . LYS A 1 675  ? 142.992 181.634 156.288 1.00 56.62  ? 1020 LYS A CE    1 
ATOM   2347 N  NZ    . LYS A 1 675  ? 142.086 182.537 155.528 1.00 60.68  ? 1020 LYS A NZ    1 
ATOM   2348 N  N     . PHE A 1 676  ? 149.212 178.942 155.195 1.00 36.48  ? 1021 PHE A N     1 
ATOM   2349 C  CA    . PHE A 1 676  ? 150.350 178.758 154.304 1.00 36.30  ? 1021 PHE A CA    1 
ATOM   2350 C  C     . PHE A 1 676  ? 149.818 178.417 152.924 1.00 44.83  ? 1021 PHE A C     1 
ATOM   2351 O  O     . PHE A 1 676  ? 149.130 177.406 152.755 1.00 48.41  ? 1021 PHE A O     1 
ATOM   2352 C  CB    . PHE A 1 676  ? 151.280 177.654 154.809 1.00 42.66  ? 1021 PHE A CB    1 
ATOM   2353 C  CG    . PHE A 1 676  ? 152.337 178.137 155.755 1.00 43.78  ? 1021 PHE A CG    1 
ATOM   2354 C  CD1   . PHE A 1 676  ? 153.220 179.124 155.378 1.00 46.15  ? 1021 PHE A CD1   1 
ATOM   2355 C  CD2   . PHE A 1 676  ? 152.453 177.594 157.017 1.00 47.90  ? 1021 PHE A CD2   1 
ATOM   2356 C  CE1   . PHE A 1 676  ? 154.192 179.564 156.242 1.00 42.89  ? 1021 PHE A CE1   1 
ATOM   2357 C  CE2   . PHE A 1 676  ? 153.424 178.032 157.880 1.00 45.18  ? 1021 PHE A CE2   1 
ATOM   2358 C  CZ    . PHE A 1 676  ? 154.293 179.019 157.492 1.00 41.06  ? 1021 PHE A CZ    1 
ATOM   2359 N  N     . TYR A 1 677  ? 150.135 179.256 151.943 1.00 54.75  ? 1022 TYR A N     1 
ATOM   2360 C  CA    . TYR A 1 677  ? 149.610 179.097 150.595 1.00 53.63  ? 1022 TYR A CA    1 
ATOM   2361 C  C     . TYR A 1 677  ? 150.407 178.035 149.853 1.00 51.98  ? 1022 TYR A C     1 
ATOM   2362 O  O     . TYR A 1 677  ? 151.630 178.144 149.731 1.00 59.15  ? 1022 TYR A O     1 
ATOM   2363 C  CB    . TYR A 1 677  ? 149.680 180.424 149.842 1.00 52.94  ? 1022 TYR A CB    1 
ATOM   2364 C  CG    . TYR A 1 677  ? 148.506 181.342 150.064 1.00 48.36  ? 1022 TYR A CG    1 
ATOM   2365 C  CD1   . TYR A 1 677  ? 147.385 181.272 149.256 1.00 54.21  ? 1022 TYR A CD1   1 
ATOM   2366 C  CD2   . TYR A 1 677  ? 148.526 182.291 151.071 1.00 46.84  ? 1022 TYR A CD2   1 
ATOM   2367 C  CE1   . TYR A 1 677  ? 146.315 182.112 149.450 1.00 63.71  ? 1022 TYR A CE1   1 
ATOM   2368 C  CE2   . TYR A 1 677  ? 147.461 183.135 151.273 1.00 56.59  ? 1022 TYR A CE2   1 
ATOM   2369 C  CZ    . TYR A 1 677  ? 146.357 183.041 150.461 1.00 60.87  ? 1022 TYR A CZ    1 
ATOM   2370 O  OH    . TYR A 1 677  ? 145.289 183.884 150.660 1.00 57.32  ? 1022 TYR A OH    1 
ATOM   2371 N  N     . ARG A 1 678  ? 149.732 177.015 149.366 1.00 37.44  ? 1023 ARG A N     1 
ATOM   2372 C  CA    . ARG A 1 678  ? 150.429 176.153 148.432 1.00 33.41  ? 1023 ARG A CA    1 
ATOM   2373 C  C     . ARG A 1 678  ? 150.543 176.861 147.086 1.00 50.12  ? 1023 ARG A C     1 
ATOM   2374 O  O     . ARG A 1 678  ? 149.744 177.749 146.780 1.00 66.14  ? 1023 ARG A O     1 
ATOM   2375 C  CB    . ARG A 1 678  ? 149.694 174.832 148.270 1.00 31.08  ? 1023 ARG A CB    1 
ATOM   2376 C  CG    . ARG A 1 678  ? 149.917 173.871 149.410 1.00 35.09  ? 1023 ARG A CG    1 
ATOM   2377 C  CD    . ARG A 1 678  ? 149.163 172.586 149.185 1.00 43.22  ? 1023 ARG A CD    1 
ATOM   2378 N  NE    . ARG A 1 678  ? 149.326 171.665 150.301 1.00 37.81  ? 1023 ARG A NE    1 
ATOM   2379 C  CZ    . ARG A 1 678  ? 150.270 170.738 150.366 1.00 37.24  ? 1023 ARG A CZ    1 
ATOM   2380 N  NH1   . ARG A 1 678  ? 151.158 170.590 149.400 1.00 46.11  ? 1023 ARG A NH1   1 
ATOM   2381 N  NH2   . ARG A 1 678  ? 150.323 169.940 151.428 1.00 34.52  ? 1023 ARG A NH2   1 
ATOM   2382 N  N     . PRO A 1 679  ? 151.538 176.506 146.271 1.00 33.50  ? 1024 PRO A N     1 
ATOM   2383 C  CA    . PRO A 1 679  ? 151.695 177.193 144.980 1.00 32.26  ? 1024 PRO A CA    1 
ATOM   2384 C  C     . PRO A 1 679  ? 150.483 177.083 144.072 1.00 40.50  ? 1024 PRO A C     1 
ATOM   2385 O  O     . PRO A 1 679  ? 150.250 177.989 143.263 1.00 48.48  ? 1024 PRO A O     1 
ATOM   2386 C  CB    . PRO A 1 679  ? 152.924 176.506 144.375 1.00 31.94  ? 1024 PRO A CB    1 
ATOM   2387 C  CG    . PRO A 1 679  ? 153.694 176.052 145.551 1.00 37.56  ? 1024 PRO A CG    1 
ATOM   2388 C  CD    . PRO A 1 679  ? 152.671 175.613 146.551 1.00 37.65  ? 1024 PRO A CD    1 
ATOM   2389 N  N     . GLU A 1 680  ? 149.700 176.014 144.174 1.00 44.25  ? 1025 GLU A N     1 
ATOM   2390 C  CA    . GLU A 1 680  ? 148.480 175.895 143.389 1.00 40.48  ? 1025 GLU A CA    1 
ATOM   2391 C  C     . GLU A 1 680  ? 147.287 176.570 144.048 1.00 37.20  ? 1025 GLU A C     1 
ATOM   2392 O  O     . GLU A 1 680  ? 146.180 176.507 143.507 1.00 49.64  ? 1025 GLU A O     1 
ATOM   2393 C  CB    . GLU A 1 680  ? 148.151 174.424 143.121 1.00 45.80  ? 1025 GLU A CB    1 
ATOM   2394 C  CG    . GLU A 1 680  ? 147.989 173.576 144.358 1.00 44.76  ? 1025 GLU A CG    1 
ATOM   2395 C  CD    . GLU A 1 680  ? 149.037 172.491 144.450 1.00 46.14  ? 1025 GLU A CD    1 
ATOM   2396 O  OE1   . GLU A 1 680  ? 150.236 172.812 144.323 1.00 42.90  ? 1025 GLU A OE1   1 
ATOM   2397 O  OE2   . GLU A 1 680  ? 148.664 171.317 144.644 1.00 49.59  ? 1025 GLU A OE2   1 
ATOM   2398 N  N     . ASN A 1 681  ? 147.480 177.200 145.205 1.00 40.03  ? 1026 ASN A N     1 
ATOM   2399 C  CA    . ASN A 1 681  ? 146.423 177.941 145.873 1.00 47.05  ? 1026 ASN A CA    1 
ATOM   2400 C  C     . ASN A 1 681  ? 146.488 179.437 145.609 1.00 50.86  ? 1026 ASN A C     1 
ATOM   2401 O  O     . ASN A 1 681  ? 145.537 180.149 145.942 1.00 56.10  ? 1026 ASN A O     1 
ATOM   2402 C  CB    . ASN A 1 681  ? 146.477 177.694 147.383 1.00 45.86  ? 1026 ASN A CB    1 
ATOM   2403 C  CG    . ASN A 1 681  ? 146.219 176.252 147.741 1.00 53.20  ? 1026 ASN A CG    1 
ATOM   2404 O  OD1   . ASN A 1 681  ? 146.683 175.764 148.769 1.00 57.91  ? 1026 ASN A OD1   1 
ATOM   2405 N  ND2   . ASN A 1 681  ? 145.476 175.557 146.891 1.00 53.63  ? 1026 ASN A ND2   1 
ATOM   2406 N  N     . THR A 1 682  ? 147.573 179.924 145.017 1.00 44.12  ? 1027 THR A N     1 
ATOM   2407 C  CA    . THR A 1 682  ? 147.723 181.344 144.735 1.00 55.64  ? 1027 THR A CA    1 
ATOM   2408 C  C     . THR A 1 682  ? 146.850 181.716 143.539 1.00 58.86  ? 1027 THR A C     1 
ATOM   2409 O  O     . THR A 1 682  ? 146.061 180.909 143.040 1.00 54.69  ? 1027 THR A O     1 
ATOM   2410 C  CB    . THR A 1 682  ? 149.192 181.680 144.500 1.00 56.38  ? 1027 THR A CB    1 
ATOM   2411 O  OG1   . THR A 1 682  ? 149.683 180.922 143.391 1.00 57.43  ? 1027 THR A OG1   1 
ATOM   2412 C  CG2   . THR A 1 682  ? 150.012 181.340 145.724 1.00 53.20  ? 1027 THR A CG2   1 
ATOM   2413 N  N     . HIS A 1 683  ? 146.972 182.959 143.067 1.00 63.34  ? 1028 HIS A N     1 
ATOM   2414 C  CA    . HIS A 1 683  ? 146.209 183.370 141.894 1.00 62.94  ? 1028 HIS A CA    1 
ATOM   2415 C  C     . HIS A 1 683  ? 146.604 182.543 140.680 1.00 60.27  ? 1028 HIS A C     1 
ATOM   2416 O  O     . HIS A 1 683  ? 145.751 182.177 139.863 1.00 62.65  ? 1028 HIS A O     1 
ATOM   2417 C  CB    . HIS A 1 683  ? 146.404 184.862 141.628 1.00 63.95  ? 1028 HIS A CB    1 
ATOM   2418 C  CG    . HIS A 1 683  ? 147.772 185.219 141.141 1.00 61.40  ? 1028 HIS A CG    1 
ATOM   2419 N  ND1   . HIS A 1 683  ? 148.852 185.347 141.986 1.00 62.20  ? 1028 HIS A ND1   1 
ATOM   2420 C  CD2   . HIS A 1 683  ? 148.234 185.482 139.896 1.00 65.62  ? 1028 HIS A CD2   1 
ATOM   2421 C  CE1   . HIS A 1 683  ? 149.922 185.671 141.282 1.00 64.52  ? 1028 HIS A CE1   1 
ATOM   2422 N  NE2   . HIS A 1 683  ? 149.574 185.760 140.012 1.00 67.44  ? 1028 HIS A NE2   1 
ATOM   2423 N  N     . LYS A 1 684  ? 147.890 182.236 140.546 1.00 63.44  ? 1029 LYS A N     1 
ATOM   2424 C  CA    . LYS A 1 684  ? 148.324 181.234 139.585 1.00 66.20  ? 1029 LYS A CA    1 
ATOM   2425 C  C     . LYS A 1 684  ? 147.819 179.873 140.041 1.00 63.61  ? 1029 LYS A C     1 
ATOM   2426 O  O     . LYS A 1 684  ? 148.186 179.397 141.119 1.00 72.96  ? 1029 LYS A O     1 
ATOM   2427 C  CB    . LYS A 1 684  ? 149.844 181.228 139.466 1.00 60.99  ? 1029 LYS A CB    1 
ATOM   2428 C  CG    . LYS A 1 684  ? 150.483 182.598 139.553 1.00 63.42  ? 1029 LYS A CG    1 
ATOM   2429 C  CD    . LYS A 1 684  ? 151.985 182.511 139.367 1.00 67.12  ? 1029 LYS A CD    1 
ATOM   2430 C  CE    . LYS A 1 684  ? 152.644 181.804 140.536 1.00 67.96  ? 1029 LYS A CE    1 
ATOM   2431 N  NZ    . LYS A 1 684  ? 153.934 182.445 140.905 1.00 66.30  ? 1029 LYS A NZ    1 
ATOM   2432 N  N     . SER A 1 685  ? 146.990 179.241 139.220 1.00 54.79  ? 1030 SER A N     1 
ATOM   2433 C  CA    . SER A 1 685  ? 146.403 177.959 139.581 1.00 56.46  ? 1030 SER A CA    1 
ATOM   2434 C  C     . SER A 1 685  ? 147.425 176.851 139.385 1.00 56.79  ? 1030 SER A C     1 
ATOM   2435 O  O     . SER A 1 685  ? 148.628 177.119 139.329 1.00 59.18  ? 1030 SER A O     1 
ATOM   2436 C  CB    . SER A 1 685  ? 145.144 177.685 138.760 1.00 59.35  ? 1030 SER A CB    1 
ATOM   2437 O  OG    . SER A 1 685  ? 144.233 176.885 139.492 1.00 60.88  ? 1030 SER A OG    1 
ATOM   2438 N  N     . THR A 1 686  ? 146.954 175.606 139.319 1.00 54.13  ? 1031 THR A N     1 
ATOM   2439 C  CA    . THR A 1 686  ? 147.772 174.408 139.147 1.00 52.95  ? 1031 THR A CA    1 
ATOM   2440 C  C     . THR A 1 686  ? 148.949 174.599 138.187 1.00 57.45  ? 1031 THR A C     1 
ATOM   2441 O  O     . THR A 1 686  ? 150.028 174.055 138.452 1.00 61.00  ? 1031 THR A O     1 
ATOM   2442 C  CB    . THR A 1 686  ? 146.894 173.244 138.677 1.00 56.76  ? 1031 THR A CB    1 
ATOM   2443 O  OG1   . THR A 1 686  ? 145.810 173.063 139.595 1.00 58.75  ? 1031 THR A OG1   1 
ATOM   2444 C  CG2   . THR A 1 686  ? 147.697 171.959 138.602 1.00 54.98  ? 1031 THR A CG2   1 
ATOM   2445 N  N     . PRO A 1 687  ? 148.814 175.365 137.069 1.00 59.30  ? 1032 PRO A N     1 
ATOM   2446 C  CA    . PRO A 1 687  ? 149.996 175.654 136.240 1.00 55.29  ? 1032 PRO A CA    1 
ATOM   2447 C  C     . PRO A 1 687  ? 151.190 176.231 136.989 1.00 53.37  ? 1032 PRO A C     1 
ATOM   2448 O  O     . PRO A 1 687  ? 152.279 176.341 136.419 1.00 54.85  ? 1032 PRO A O     1 
ATOM   2449 C  CB    . PRO A 1 687  ? 149.458 176.661 135.221 1.00 54.89  ? 1032 PRO A CB    1 
ATOM   2450 C  CG    . PRO A 1 687  ? 148.061 176.254 135.027 1.00 62.03  ? 1032 PRO A CG    1 
ATOM   2451 C  CD    . PRO A 1 687  ? 147.572 175.704 136.344 1.00 58.85  ? 1032 PRO A CD    1 
ATOM   2452 N  N     . ALA A 1 688  ? 151.007 176.617 138.249 1.00 56.90  ? 1033 ALA A N     1 
ATOM   2453 C  CA    . ALA A 1 688  ? 152.125 177.021 139.090 1.00 58.75  ? 1033 ALA A CA    1 
ATOM   2454 C  C     . ALA A 1 688  ? 152.751 175.854 139.835 1.00 53.91  ? 1033 ALA A C     1 
ATOM   2455 O  O     . ALA A 1 688  ? 153.786 176.036 140.483 1.00 51.68  ? 1033 ALA A O     1 
ATOM   2456 C  CB    . ALA A 1 688  ? 151.679 178.084 140.098 1.00 54.88  ? 1033 ALA A CB    1 
ATOM   2457 N  N     . SER A 1 689  ? 152.151 174.668 139.761 1.00 46.96  ? 1034 SER A N     1 
ATOM   2458 C  CA    . SER A 1 689  ? 152.663 173.479 140.427 1.00 47.17  ? 1034 SER A CA    1 
ATOM   2459 C  C     . SER A 1 689  ? 153.232 172.476 139.431 1.00 58.21  ? 1034 SER A C     1 
ATOM   2460 O  O     . SER A 1 689  ? 153.083 171.266 139.606 1.00 66.48  ? 1034 SER A O     1 
ATOM   2461 C  CB    . SER A 1 689  ? 151.570 172.821 141.264 1.00 50.93  ? 1034 SER A CB    1 
ATOM   2462 O  OG    . SER A 1 689  ? 150.791 171.944 140.474 1.00 52.92  ? 1034 SER A OG    1 
ATOM   2463 N  N     . TYR A 1 690  ? 153.870 172.967 138.370 1.00 50.84  ? 1035 TYR A N     1 
ATOM   2464 C  CA    . TYR A 1 690  ? 154.516 172.103 137.392 1.00 45.91  ? 1035 TYR A CA    1 
ATOM   2465 C  C     . TYR A 1 690  ? 156.022 172.027 137.575 1.00 49.52  ? 1035 TYR A C     1 
ATOM   2466 O  O     . TYR A 1 690  ? 156.612 170.973 137.321 1.00 56.33  ? 1035 TYR A O     1 
ATOM   2467 C  CB    . TYR A 1 690  ? 154.217 172.586 135.968 1.00 49.48  ? 1035 TYR A CB    1 
ATOM   2468 C  CG    . TYR A 1 690  ? 152.766 172.480 135.563 1.00 50.47  ? 1035 TYR A CG    1 
ATOM   2469 C  CD1   . TYR A 1 690  ? 151.861 171.763 136.327 1.00 53.78  ? 1035 TYR A CD1   1 
ATOM   2470 C  CD2   . TYR A 1 690  ? 152.304 173.096 134.410 1.00 47.65  ? 1035 TYR A CD2   1 
ATOM   2471 C  CE1   . TYR A 1 690  ? 150.537 171.666 135.959 1.00 52.53  ? 1035 TYR A CE1   1 
ATOM   2472 C  CE2   . TYR A 1 690  ? 150.982 173.002 134.034 1.00 48.06  ? 1035 TYR A CE2   1 
ATOM   2473 C  CZ    . TYR A 1 690  ? 150.103 172.286 134.813 1.00 48.24  ? 1035 TYR A CZ    1 
ATOM   2474 O  OH    . TYR A 1 690  ? 148.784 172.190 134.446 1.00 55.28  ? 1035 TYR A OH    1 
ATOM   2475 N  N     . HIS A 1 691  ? 156.653 173.115 138.014 1.00 48.89  ? 1036 HIS A N     1 
ATOM   2476 C  CA    . HIS A 1 691  ? 158.099 173.173 138.180 1.00 51.52  ? 1036 HIS A CA    1 
ATOM   2477 C  C     . HIS A 1 691  ? 158.512 173.368 139.631 1.00 49.34  ? 1036 HIS A C     1 
ATOM   2478 O  O     . HIS A 1 691  ? 159.711 173.363 139.928 1.00 51.39  ? 1036 HIS A O     1 
ATOM   2479 C  CB    . HIS A 1 691  ? 158.686 174.307 137.334 1.00 53.78  ? 1036 HIS A CB    1 
ATOM   2480 C  CG    . HIS A 1 691  ? 158.485 174.139 135.861 1.00 57.11  ? 1036 HIS A CG    1 
ATOM   2481 N  ND1   . HIS A 1 691  ? 157.264 174.326 135.250 1.00 57.13  ? 1036 HIS A ND1   1 
ATOM   2482 C  CD2   . HIS A 1 691  ? 159.354 173.822 134.872 1.00 56.25  ? 1036 HIS A CD2   1 
ATOM   2483 C  CE1   . HIS A 1 691  ? 157.387 174.121 133.951 1.00 53.82  ? 1036 HIS A CE1   1 
ATOM   2484 N  NE2   . HIS A 1 691  ? 158.645 173.814 133.696 1.00 56.65  ? 1036 HIS A NE2   1 
ATOM   2485 N  N     . ALA A 1 692  ? 157.560 173.542 140.538 1.00 55.04  ? 1037 ALA A N     1 
ATOM   2486 C  CA    . ALA A 1 692  ? 157.850 173.909 141.915 1.00 55.30  ? 1037 ALA A CA    1 
ATOM   2487 C  C     . ALA A 1 692  ? 158.115 172.673 142.762 1.00 52.30  ? 1037 ALA A C     1 
ATOM   2488 O  O     . ALA A 1 692  ? 157.690 171.562 142.438 1.00 56.06  ? 1037 ALA A O     1 
ATOM   2489 C  CB    . ALA A 1 692  ? 156.697 174.716 142.515 1.00 52.50  ? 1037 ALA A CB    1 
ATOM   2490 N  N     . ASP A 1 693  ? 158.831 172.886 143.863 1.00 45.08  ? 1038 ASP A N     1 
ATOM   2491 C  CA    . ASP A 1 693  ? 159.141 171.802 144.780 1.00 47.31  ? 1038 ASP A CA    1 
ATOM   2492 C  C     . ASP A 1 693  ? 157.871 171.268 145.428 1.00 46.37  ? 1038 ASP A C     1 
ATOM   2493 O  O     . ASP A 1 693  ? 156.898 171.995 145.638 1.00 47.14  ? 1038 ASP A O     1 
ATOM   2494 C  CB    . ASP A 1 693  ? 160.110 172.274 145.860 1.00 42.91  ? 1038 ASP A CB    1 
ATOM   2495 C  CG    . ASP A 1 693  ? 161.335 172.944 145.288 1.00 49.25  ? 1038 ASP A CG    1 
ATOM   2496 O  OD1   . ASP A 1 693  ? 161.176 173.909 144.513 1.00 51.95  ? 1038 ASP A OD1   1 
ATOM   2497 O  OD2   . ASP A 1 693  ? 162.457 172.509 145.616 1.00 49.89  ? 1038 ASP A OD2   1 
ATOM   2498 N  N     . ILE A 1 694  ? 157.887 169.971 145.738 1.00 38.37  ? 1039 ILE A N     1 
ATOM   2499 C  CA    . ILE A 1 694  ? 156.750 169.345 146.394 1.00 36.99  ? 1039 ILE A CA    1 
ATOM   2500 C  C     . ILE A 1 694  ? 156.504 169.926 147.780 1.00 42.13  ? 1039 ILE A C     1 
ATOM   2501 O  O     . ILE A 1 694  ? 155.347 170.074 148.191 1.00 45.28  ? 1039 ILE A O     1 
ATOM   2502 C  CB    . ILE A 1 694  ? 156.969 167.822 146.444 1.00 31.00  ? 1039 ILE A CB    1 
ATOM   2503 C  CG1   . ILE A 1 694  ? 156.674 167.197 145.085 1.00 39.83  ? 1039 ILE A CG1   1 
ATOM   2504 C  CG2   . ILE A 1 694  ? 156.095 167.183 147.469 1.00 37.66  ? 1039 ILE A CG2   1 
ATOM   2505 C  CD1   . ILE A 1 694  ? 155.206 167.047 144.793 1.00 34.12  ? 1039 ILE A CD1   1 
ATOM   2506 N  N     . ASN A 1 695  ? 157.555 170.300 148.499 1.00 43.45  ? 1040 ASN A N     1 
ATOM   2507 C  CA    . ASN A 1 695  ? 157.446 170.763 149.876 1.00 38.76  ? 1040 ASN A CA    1 
ATOM   2508 C  C     . ASN A 1 695  ? 157.656 172.270 149.972 1.00 54.01  ? 1040 ASN A C     1 
ATOM   2509 O  O     . ASN A 1 695  ? 158.292 172.769 150.902 1.00 61.34  ? 1040 ASN A O     1 
ATOM   2510 C  CB    . ASN A 1 695  ? 158.435 170.023 150.774 1.00 33.92  ? 1040 ASN A CB    1 
ATOM   2511 C  CG    . ASN A 1 695  ? 159.878 170.355 150.454 1.00 41.55  ? 1040 ASN A CG    1 
ATOM   2512 O  OD1   . ASN A 1 695  ? 160.233 170.585 149.302 1.00 50.36  ? 1040 ASN A OD1   1 
ATOM   2513 N  ND2   . ASN A 1 695  ? 160.716 170.389 151.479 1.00 45.15  ? 1040 ASN A ND2   1 
ATOM   2514 N  N     . LEU A 1 696  ? 157.117 173.018 149.013 1.00 45.53  ? 1041 LEU A N     1 
ATOM   2515 C  CA    . LEU A 1 696  ? 157.240 174.470 148.982 1.00 33.85  ? 1041 LEU A CA    1 
ATOM   2516 C  C     . LEU A 1 696  ? 155.909 175.107 149.349 1.00 36.72  ? 1041 LEU A C     1 
ATOM   2517 O  O     . LEU A 1 696  ? 154.857 174.669 148.875 1.00 51.17  ? 1041 LEU A O     1 
ATOM   2518 C  CB    . LEU A 1 696  ? 157.684 174.957 147.604 1.00 36.42  ? 1041 LEU A CB    1 
ATOM   2519 C  CG    . LEU A 1 696  ? 157.727 176.475 147.428 1.00 37.32  ? 1041 LEU A CG    1 
ATOM   2520 C  CD1   . LEU A 1 696  ? 159.035 177.030 147.949 1.00 43.79  ? 1041 LEU A CD1   1 
ATOM   2521 C  CD2   . LEU A 1 696  ? 157.527 176.852 145.974 1.00 42.81  ? 1041 LEU A CD2   1 
ATOM   2522 N  N     . LEU A 1 697  ? 155.960 176.134 150.192 1.00 44.70  ? 1042 LEU A N     1 
ATOM   2523 C  CA    . LEU A 1 697  ? 154.791 176.904 150.585 1.00 41.80  ? 1042 LEU A CA    1 
ATOM   2524 C  C     . LEU A 1 697  ? 155.135 178.387 150.545 1.00 45.09  ? 1042 LEU A C     1 
ATOM   2525 O  O     . LEU A 1 697  ? 156.294 178.774 150.389 1.00 54.84  ? 1042 LEU A O     1 
ATOM   2526 C  CB    . LEU A 1 697  ? 154.299 176.512 151.985 1.00 38.02  ? 1042 LEU A CB    1 
ATOM   2527 C  CG    . LEU A 1 697  ? 154.176 175.029 152.325 1.00 37.21  ? 1042 LEU A CG    1 
ATOM   2528 C  CD1   . LEU A 1 697  ? 153.860 174.857 153.793 1.00 39.44  ? 1042 LEU A CD1   1 
ATOM   2529 C  CD2   . LEU A 1 697  ? 153.117 174.367 151.480 1.00 46.57  ? 1042 LEU A CD2   1 
ATOM   2530 N  N     . TYR A 1 698  ? 154.109 179.221 150.681 1.00 45.17  ? 1043 TYR A N     1 
ATOM   2531 C  CA    . TYR A 1 698  ? 154.260 180.667 150.725 1.00 47.10  ? 1043 TYR A CA    1 
ATOM   2532 C  C     . TYR A 1 698  ? 153.651 181.187 152.017 1.00 54.93  ? 1043 TYR A C     1 
ATOM   2533 O  O     . TYR A 1 698  ? 152.541 180.793 152.384 1.00 63.84  ? 1043 TYR A O     1 
ATOM   2534 C  CB    . TYR A 1 698  ? 153.588 181.331 149.521 1.00 51.83  ? 1043 TYR A CB    1 
ATOM   2535 C  CG    . TYR A 1 698  ? 154.248 181.029 148.198 1.00 55.85  ? 1043 TYR A CG    1 
ATOM   2536 C  CD1   . TYR A 1 698  ? 155.538 181.458 147.930 1.00 57.39  ? 1043 TYR A CD1   1 
ATOM   2537 C  CD2   . TYR A 1 698  ? 153.578 180.320 147.213 1.00 53.63  ? 1043 TYR A CD2   1 
ATOM   2538 C  CE1   . TYR A 1 698  ? 156.144 181.188 146.724 1.00 51.46  ? 1043 TYR A CE1   1 
ATOM   2539 C  CE2   . TYR A 1 698  ? 154.177 180.044 146.003 1.00 56.77  ? 1043 TYR A CE2   1 
ATOM   2540 C  CZ    . TYR A 1 698  ? 155.459 180.480 145.765 1.00 57.29  ? 1043 TYR A CZ    1 
ATOM   2541 O  OH    . TYR A 1 698  ? 156.061 180.208 144.560 1.00 64.92  ? 1043 TYR A OH    1 
ATOM   2542 N  N     . TRP A 1 699  ? 154.377 182.063 152.701 1.00 66.83  ? 1044 TRP A N     1 
ATOM   2543 C  CA    . TRP A 1 699  ? 153.886 182.639 153.944 1.00 65.59  ? 1044 TRP A CA    1 
ATOM   2544 C  C     . TRP A 1 699  ? 152.778 183.647 153.666 1.00 68.22  ? 1044 TRP A C     1 
ATOM   2545 O  O     . TRP A 1 699  ? 152.717 184.259 152.597 1.00 82.75  ? 1044 TRP A O     1 
ATOM   2546 C  CB    . TRP A 1 699  ? 155.031 183.310 154.700 1.00 67.26  ? 1044 TRP A CB    1 
ATOM   2547 C  CG    . TRP A 1 699  ? 154.601 184.189 155.829 1.00 67.60  ? 1044 TRP A CG    1 
ATOM   2548 C  CD1   . TRP A 1 699  ? 154.426 185.539 155.795 1.00 70.14  ? 1044 TRP A CD1   1 
ATOM   2549 C  CD2   . TRP A 1 699  ? 154.303 183.779 157.166 1.00 69.48  ? 1044 TRP A CD2   1 
ATOM   2550 N  NE1   . TRP A 1 699  ? 154.034 185.997 157.028 1.00 68.63  ? 1044 TRP A NE1   1 
ATOM   2551 C  CE2   . TRP A 1 699  ? 153.951 184.934 157.887 1.00 72.33  ? 1044 TRP A CE2   1 
ATOM   2552 C  CE3   . TRP A 1 699  ? 154.299 182.547 157.824 1.00 68.27  ? 1044 TRP A CE3   1 
ATOM   2553 C  CZ2   . TRP A 1 699  ? 153.599 184.894 159.231 1.00 73.79  ? 1044 TRP A CZ2   1 
ATOM   2554 C  CZ3   . TRP A 1 699  ? 153.949 182.510 159.155 1.00 72.03  ? 1044 TRP A CZ3   1 
ATOM   2555 C  CH2   . TRP A 1 699  ? 153.606 183.674 159.846 1.00 73.05  ? 1044 TRP A CH2   1 
ATOM   2556 N  N     . SER A 1 700  ? 151.890 183.813 154.642 1.00 49.93  ? 1045 SER A N     1 
ATOM   2557 C  CA    . SER A 1 700  ? 150.811 184.782 154.531 1.00 56.92  ? 1045 SER A CA    1 
ATOM   2558 C  C     . SER A 1 700  ? 150.496 185.327 155.913 1.00 64.92  ? 1045 SER A C     1 
ATOM   2559 O  O     . SER A 1 700  ? 150.898 184.760 156.931 1.00 77.82  ? 1045 SER A O     1 
ATOM   2560 C  CB    . SER A 1 700  ? 149.562 184.164 153.902 1.00 57.95  ? 1045 SER A CB    1 
ATOM   2561 O  OG    . SER A 1 700  ? 149.044 183.140 154.728 1.00 67.96  ? 1045 SER A OG    1 
ATOM   2562 N  N     . ASP A 1 701  ? 149.777 186.448 155.940 1.00 68.18  ? 1046 ASP A N     1 
ATOM   2563 C  CA    . ASP A 1 701  ? 149.358 187.076 157.186 1.00 70.30  ? 1046 ASP A CA    1 
ATOM   2564 C  C     . ASP A 1 701  ? 147.859 186.920 157.422 1.00 70.32  ? 1046 ASP A C     1 
ATOM   2565 O  O     . ASP A 1 701  ? 147.234 187.765 158.066 1.00 71.04  ? 1046 ASP A O     1 
ATOM   2566 C  CB    . ASP A 1 701  ? 149.752 188.551 157.204 1.00 74.56  ? 1046 ASP A CB    1 
ATOM   2567 C  CG    . ASP A 1 701  ? 151.238 188.751 157.402 1.00 77.28  ? 1046 ASP A CG    1 
ATOM   2568 O  OD1   . ASP A 1 701  ? 151.968 187.741 157.482 1.00 72.30  ? 1046 ASP A OD1   1 
ATOM   2569 O  OD2   . ASP A 1 701  ? 151.678 189.917 157.481 1.00 80.87  ? 1046 ASP A OD2   1 
ATOM   2570 N  N     . GLU A 1 702  ? 147.275 185.846 156.905 1.00 64.87  ? 1047 GLU A N     1 
ATOM   2571 C  CA    . GLU A 1 702  ? 145.866 185.537 157.101 1.00 70.15  ? 1047 GLU A CA    1 
ATOM   2572 C  C     . GLU A 1 702  ? 145.748 184.413 158.120 1.00 72.45  ? 1047 GLU A C     1 
ATOM   2573 O  O     . GLU A 1 702  ? 146.371 183.360 157.959 1.00 69.85  ? 1047 GLU A O     1 
ATOM   2574 C  CB    . GLU A 1 702  ? 145.208 185.129 155.783 1.00 66.60  ? 1047 GLU A CB    1 
ATOM   2575 C  CG    . GLU A 1 702  ? 145.511 186.061 154.625 1.00 69.26  ? 1047 GLU A CG    1 
ATOM   2576 C  CD    . GLU A 1 702  ? 144.791 185.658 153.354 1.00 76.05  ? 1047 GLU A CD    1 
ATOM   2577 O  OE1   . GLU A 1 702  ? 143.992 184.701 153.401 1.00 74.52  ? 1047 GLU A OE1   1 
ATOM   2578 O  OE2   . GLU A 1 702  ? 145.024 186.298 152.307 1.00 80.23  ? 1047 GLU A OE2   1 
ATOM   2579 N  N     . GLU A 1 703  ? 144.952 184.636 159.162 1.00 67.68  ? 1048 GLU A N     1 
ATOM   2580 C  CA    . GLU A 1 703  ? 144.809 183.676 160.243 1.00 62.86  ? 1048 GLU A CA    1 
ATOM   2581 C  C     . GLU A 1 703  ? 143.382 183.148 160.299 1.00 65.98  ? 1048 GLU A C     1 
ATOM   2582 O  O     . GLU A 1 703  ? 142.434 183.818 159.878 1.00 71.52  ? 1048 GLU A O     1 
ATOM   2583 C  CB    . GLU A 1 703  ? 145.197 184.297 161.589 1.00 60.95  ? 1048 GLU A CB    1 
ATOM   2584 C  CG    . GLU A 1 703  ? 144.082 185.064 162.270 1.00 66.94  ? 1048 GLU A CG    1 
ATOM   2585 C  CD    . GLU A 1 703  ? 143.934 186.469 161.730 1.00 70.05  ? 1048 GLU A CD    1 
ATOM   2586 O  OE1   . GLU A 1 703  ? 144.848 186.928 161.015 1.00 69.47  ? 1048 GLU A OE1   1 
ATOM   2587 O  OE2   . GLU A 1 703  ? 142.905 187.115 162.021 1.00 67.22  ? 1048 GLU A OE2   1 
ATOM   2588 N  N     . ALA A 1 704  ? 143.245 181.930 160.813 1.00 50.79  ? 1049 ALA A N     1 
ATOM   2589 C  CA    . ALA A 1 704  ? 141.962 181.256 160.932 1.00 51.78  ? 1049 ALA A CA    1 
ATOM   2590 C  C     . ALA A 1 704  ? 141.853 180.617 162.309 1.00 61.05  ? 1049 ALA A C     1 
ATOM   2591 O  O     . ALA A 1 704  ? 142.848 180.449 163.014 1.00 66.41  ? 1049 ALA A O     1 
ATOM   2592 C  CB    . ALA A 1 704  ? 141.781 180.192 159.844 1.00 50.75  ? 1049 ALA A CB    1 
ATOM   2593 N  N     . VAL A 1 705  ? 140.627 180.270 162.693 1.00 67.41  ? 1050 VAL A N     1 
ATOM   2594 C  CA    . VAL A 1 705  ? 140.352 179.627 163.975 1.00 64.21  ? 1050 VAL A CA    1 
ATOM   2595 C  C     . VAL A 1 705  ? 139.770 178.249 163.700 1.00 64.44  ? 1050 VAL A C     1 
ATOM   2596 O  O     . VAL A 1 705  ? 138.786 178.118 162.963 1.00 71.15  ? 1050 VAL A O     1 
ATOM   2597 C  CB    . VAL A 1 705  ? 139.407 180.466 164.849 1.00 64.84  ? 1050 VAL A CB    1 
ATOM   2598 C  CG1   . VAL A 1 705  ? 140.164 181.619 165.480 1.00 65.86  ? 1050 VAL A CG1   1 
ATOM   2599 C  CG2   . VAL A 1 705  ? 138.241 180.992 164.027 1.00 68.19  ? 1050 VAL A CG2   1 
ATOM   2600 N  N     . VAL A 1 706  ? 140.389 177.221 164.276 1.00 56.00  ? 1051 VAL A N     1 
ATOM   2601 C  CA    . VAL A 1 706  ? 139.996 175.836 164.041 1.00 56.91  ? 1051 VAL A CA    1 
ATOM   2602 C  C     . VAL A 1 706  ? 140.011 175.087 165.366 1.00 64.82  ? 1051 VAL A C     1 
ATOM   2603 O  O     . VAL A 1 706  ? 140.898 175.297 166.197 1.00 70.72  ? 1051 VAL A O     1 
ATOM   2604 C  CB    . VAL A 1 706  ? 140.925 175.148 163.018 1.00 54.82  ? 1051 VAL A CB    1 
ATOM   2605 C  CG1   . VAL A 1 706  ? 140.462 173.733 162.744 1.00 61.35  ? 1051 VAL A CG1   1 
ATOM   2606 C  CG2   . VAL A 1 706  ? 140.983 175.936 161.722 1.00 57.50  ? 1051 VAL A CG2   1 
ATOM   2607 N  N     . ASP A 1 707  ? 139.029 174.212 165.568 1.00 74.78  ? 1052 ASP A N     1 
ATOM   2608 C  CA    . ASP A 1 707  ? 139.021 173.378 166.763 1.00 73.56  ? 1052 ASP A CA    1 
ATOM   2609 C  C     . ASP A 1 707  ? 140.218 172.434 166.757 1.00 73.75  ? 1052 ASP A C     1 
ATOM   2610 O  O     . ASP A 1 707  ? 140.649 171.950 165.708 1.00 75.46  ? 1052 ASP A O     1 
ATOM   2611 C  CB    . ASP A 1 707  ? 137.719 172.584 166.854 1.00 75.01  ? 1052 ASP A CB    1 
ATOM   2612 C  CG    . ASP A 1 707  ? 136.552 173.433 167.318 1.00 77.14  ? 1052 ASP A CG    1 
ATOM   2613 O  OD1   . ASP A 1 707  ? 136.372 174.545 166.782 1.00 79.18  ? 1052 ASP A OD1   1 
ATOM   2614 O  OD2   . ASP A 1 707  ? 135.813 172.986 168.220 1.00 78.88  ? 1052 ASP A OD2   1 
ATOM   2615 N  N     . PHE A 1 708  ? 140.756 172.172 167.953 1.00 70.52  ? 1053 PHE A N     1 
ATOM   2616 C  CA    . PHE A 1 708  ? 141.989 171.396 168.064 1.00 68.42  ? 1053 PHE A CA    1 
ATOM   2617 C  C     . PHE A 1 708  ? 141.825 169.983 167.527 1.00 73.25  ? 1053 PHE A C     1 
ATOM   2618 O  O     . PHE A 1 708  ? 142.776 169.417 166.978 1.00 75.23  ? 1053 PHE A O     1 
ATOM   2619 C  CB    . PHE A 1 708  ? 142.454 171.348 169.517 1.00 70.24  ? 1053 PHE A CB    1 
ATOM   2620 C  CG    . PHE A 1 708  ? 143.902 170.979 169.683 1.00 72.72  ? 1053 PHE A CG    1 
ATOM   2621 C  CD1   . PHE A 1 708  ? 144.312 169.661 169.605 1.00 71.37  ? 1053 PHE A CD1   1 
ATOM   2622 C  CD2   . PHE A 1 708  ? 144.851 171.950 169.933 1.00 74.59  ? 1053 PHE A CD2   1 
ATOM   2623 C  CE1   . PHE A 1 708  ? 145.636 169.326 169.760 1.00 71.31  ? 1053 PHE A CE1   1 
ATOM   2624 C  CE2   . PHE A 1 708  ? 146.177 171.620 170.091 1.00 71.17  ? 1053 PHE A CE2   1 
ATOM   2625 C  CZ    . PHE A 1 708  ? 146.570 170.307 170.005 1.00 70.12  ? 1053 PHE A CZ    1 
ATOM   2626 N  N     . LYS A 1 709  ? 140.636 169.397 167.666 1.00 66.35  ? 1054 LYS A N     1 
ATOM   2627 C  CA    . LYS A 1 709  ? 140.428 168.029 167.212 1.00 61.59  ? 1054 LYS A CA    1 
ATOM   2628 C  C     . LYS A 1 709  ? 140.600 167.878 165.708 1.00 66.00  ? 1054 LYS A C     1 
ATOM   2629 O  O     . LYS A 1 709  ? 140.734 166.748 165.229 1.00 71.05  ? 1054 LYS A O     1 
ATOM   2630 C  CB    . LYS A 1 709  ? 139.038 167.543 167.624 1.00 62.10  ? 1054 LYS A CB    1 
ATOM   2631 C  CG    . LYS A 1 709  ? 137.901 168.400 167.098 1.00 65.72  ? 1054 LYS A CG    1 
ATOM   2632 C  CD    . LYS A 1 709  ? 136.589 168.059 167.783 1.00 68.13  ? 1054 LYS A CD    1 
ATOM   2633 C  CE    . LYS A 1 709  ? 136.695 168.218 169.290 1.00 66.73  ? 1054 LYS A CE    1 
ATOM   2634 N  NZ    . LYS A 1 709  ? 135.438 167.817 169.980 1.00 66.60  ? 1054 LYS A NZ    1 
ATOM   2635 N  N     . ALA A 1 710  ? 140.595 168.979 164.956 1.00 54.30  ? 1055 ALA A N     1 
ATOM   2636 C  CA    . ALA A 1 710  ? 140.777 168.918 163.513 1.00 50.53  ? 1055 ALA A CA    1 
ATOM   2637 C  C     . ALA A 1 710  ? 142.235 168.794 163.093 1.00 51.60  ? 1055 ALA A C     1 
ATOM   2638 O  O     . ALA A 1 710  ? 142.495 168.446 161.938 1.00 59.74  ? 1055 ALA A O     1 
ATOM   2639 C  CB    . ALA A 1 710  ? 140.160 170.153 162.856 1.00 45.51  ? 1055 ALA A CB    1 
ATOM   2640 N  N     . VAL A 1 711  ? 143.187 169.059 163.988 1.00 43.16  ? 1056 VAL A N     1 
ATOM   2641 C  CA    . VAL A 1 711  ? 144.598 168.935 163.639 1.00 35.03  ? 1056 VAL A CA    1 
ATOM   2642 C  C     . VAL A 1 711  ? 144.924 167.471 163.382 1.00 38.17  ? 1056 VAL A C     1 
ATOM   2643 O  O     . VAL A 1 711  ? 144.575 166.592 164.178 1.00 49.78  ? 1056 VAL A O     1 
ATOM   2644 C  CB    . VAL A 1 711  ? 145.480 169.521 164.749 1.00 29.95  ? 1056 VAL A CB    1 
ATOM   2645 C  CG1   . VAL A 1 711  ? 146.895 169.003 164.631 1.00 36.65  ? 1056 VAL A CG1   1 
ATOM   2646 C  CG2   . VAL A 1 711  ? 145.469 171.031 164.680 1.00 39.72  ? 1056 VAL A CG2   1 
ATOM   2647 N  N     . GLN A 1 712  ? 145.594 167.201 162.260 1.00 40.77  ? 1057 GLN A N     1 
ATOM   2648 C  CA    . GLN A 1 712  ? 145.825 165.836 161.802 1.00 38.85  ? 1057 GLN A CA    1 
ATOM   2649 C  C     . GLN A 1 712  ? 147.304 165.473 161.744 1.00 47.22  ? 1057 GLN A C     1 
ATOM   2650 O  O     . GLN A 1 712  ? 147.673 164.515 161.060 1.00 59.19  ? 1057 GLN A O     1 
ATOM   2651 C  CB    . GLN A 1 712  ? 145.182 165.624 160.433 1.00 42.78  ? 1057 GLN A CB    1 
ATOM   2652 C  CG    . GLN A 1 712  ? 143.687 165.833 160.423 1.00 47.75  ? 1057 GLN A CG    1 
ATOM   2653 C  CD    . GLN A 1 712  ? 142.945 164.643 159.865 1.00 51.14  ? 1057 GLN A CD    1 
ATOM   2654 O  OE1   . GLN A 1 712  ? 143.463 163.916 159.018 1.00 49.26  ? 1057 GLN A OE1   1 
ATOM   2655 N  NE2   . GLN A 1 712  ? 141.721 164.435 160.336 1.00 52.91  ? 1057 GLN A NE2   1 
ATOM   2656 N  N     . GLY A 1 713  ? 148.159 166.205 162.440 1.00 48.63  ? 1058 GLY A N     1 
ATOM   2657 C  CA    . GLY A 1 713  ? 149.566 165.871 162.461 1.00 48.21  ? 1058 GLY A CA    1 
ATOM   2658 C  C     . GLY A 1 713  ? 150.402 167.083 162.817 1.00 48.57  ? 1058 GLY A C     1 
ATOM   2659 O  O     . GLY A 1 713  ? 149.889 168.111 163.252 1.00 49.93  ? 1058 GLY A O     1 
ATOM   2660 N  N     . ARG A 1 714  ? 151.708 166.929 162.622 1.00 47.34  ? 1059 ARG A N     1 
ATOM   2661 C  CA    . ARG A 1 714  ? 152.660 167.993 162.895 1.00 50.48  ? 1059 ARG A CA    1 
ATOM   2662 C  C     . ARG A 1 714  ? 153.701 168.031 161.787 1.00 56.70  ? 1059 ARG A C     1 
ATOM   2663 O  O     . ARG A 1 714  ? 154.125 166.992 161.278 1.00 58.80  ? 1059 ARG A O     1 
ATOM   2664 C  CB    . ARG A 1 714  ? 153.341 167.798 164.252 1.00 53.48  ? 1059 ARG A CB    1 
ATOM   2665 C  CG    . ARG A 1 714  ? 154.447 168.790 164.538 1.00 51.58  ? 1059 ARG A CG    1 
ATOM   2666 C  CD    . ARG A 1 714  ? 154.432 169.220 165.990 1.00 50.50  ? 1059 ARG A CD    1 
ATOM   2667 N  NE    . ARG A 1 714  ? 155.070 168.246 166.868 1.00 57.06  ? 1059 ARG A NE    1 
ATOM   2668 C  CZ    . ARG A 1 714  ? 156.338 167.865 166.789 1.00 64.54  ? 1059 ARG A CZ    1 
ATOM   2669 N  NH1   . ARG A 1 714  ? 157.171 168.398 165.909 1.00 60.96  ? 1059 ARG A NH1   1 
ATOM   2670 N  NH2   . ARG A 1 714  ? 156.787 166.933 167.624 1.00 66.47  ? 1059 ARG A NH2   1 
ATOM   2671 N  N     . CYS A 1 715  ? 154.106 169.244 161.419 1.00 60.88  ? 1060 CYS A N     1 
ATOM   2672 C  CA    . CYS A 1 715  ? 155.126 169.453 160.404 1.00 57.92  ? 1060 CYS A CA    1 
ATOM   2673 C  C     . CYS A 1 715  ? 156.083 170.535 160.877 1.00 53.20  ? 1060 CYS A C     1 
ATOM   2674 O  O     . CYS A 1 715  ? 155.819 171.244 161.850 1.00 62.04  ? 1060 CYS A O     1 
ATOM   2675 C  CB    . CYS A 1 715  ? 154.512 169.843 159.057 1.00 52.62  ? 1060 CYS A CB    1 
ATOM   2676 S  SG    . CYS A 1 715  ? 153.899 171.533 158.989 1.00 46.56  ? 1060 CYS A SG    1 
ATOM   2677 N  N     . THR A 1 716  ? 157.205 170.653 160.180 1.00 46.71  ? 1061 THR A N     1 
ATOM   2678 C  CA    . THR A 1 716  ? 158.232 171.640 160.500 1.00 53.59  ? 1061 THR A CA    1 
ATOM   2679 C  C     . THR A 1 716  ? 158.335 172.610 159.327 1.00 60.64  ? 1061 THR A C     1 
ATOM   2680 O  O     . THR A 1 716  ? 159.130 172.413 158.408 1.00 65.08  ? 1061 THR A O     1 
ATOM   2681 C  CB    . THR A 1 716  ? 159.567 170.965 160.784 1.00 60.94  ? 1061 THR A CB    1 
ATOM   2682 O  OG1   . THR A 1 716  ? 159.354 169.810 161.603 1.00 62.56  ? 1061 THR A OG1   1 
ATOM   2683 C  CG2   . THR A 1 716  ? 160.504 171.923 161.502 1.00 66.39  ? 1061 THR A CG2   1 
ATOM   2684 N  N     . VAL A 1 717  ? 157.526 173.665 159.367 1.00 62.48  ? 1062 VAL A N     1 
ATOM   2685 C  CA    . VAL A 1 717  ? 157.513 174.682 158.321 1.00 57.63  ? 1062 VAL A CA    1 
ATOM   2686 C  C     . VAL A 1 717  ? 158.519 175.757 158.720 1.00 60.91  ? 1062 VAL A C     1 
ATOM   2687 O  O     . VAL A 1 717  ? 158.209 176.664 159.493 1.00 66.56  ? 1062 VAL A O     1 
ATOM   2688 C  CB    . VAL A 1 717  ? 156.112 175.258 158.109 1.00 52.47  ? 1062 VAL A CB    1 
ATOM   2689 C  CG1   . VAL A 1 717  ? 155.311 174.353 157.201 1.00 54.56  ? 1062 VAL A CG1   1 
ATOM   2690 C  CG2   . VAL A 1 717  ? 155.397 175.404 159.436 1.00 53.68  ? 1062 VAL A CG2   1 
ATOM   2691 N  N     . GLU A 1 718  ? 159.730 175.662 158.181 1.00 66.13  ? 1063 GLU A N     1 
ATOM   2692 C  CA    . GLU A 1 718  ? 160.818 176.554 158.543 1.00 68.73  ? 1063 GLU A CA    1 
ATOM   2693 C  C     . GLU A 1 718  ? 161.211 177.419 157.355 1.00 73.97  ? 1063 GLU A C     1 
ATOM   2694 O  O     . GLU A 1 718  ? 161.065 177.016 156.198 1.00 79.18  ? 1063 GLU A O     1 
ATOM   2695 C  CB    . GLU A 1 718  ? 162.038 175.769 159.033 1.00 72.75  ? 1063 GLU A CB    1 
ATOM   2696 C  CG    . GLU A 1 718  ? 162.860 176.496 160.080 1.00 79.60  ? 1063 GLU A CG    1 
ATOM   2697 C  CD    . GLU A 1 718  ? 162.231 176.435 161.456 1.00 81.63  ? 1063 GLU A CD    1 
ATOM   2698 O  OE1   . GLU A 1 718  ? 161.714 175.361 161.827 1.00 79.09  ? 1063 GLU A OE1   1 
ATOM   2699 O  OE2   . GLU A 1 718  ? 162.254 177.461 162.169 1.00 84.38  ? 1063 GLU A OE2   1 
ATOM   2700 N  N     . TYR A 1 719  ? 161.710 178.615 157.659 1.00 80.47  ? 1064 TYR A N     1 
ATOM   2701 C  CA    . TYR A 1 719  ? 162.160 179.536 156.625 1.00 81.15  ? 1064 TYR A CA    1 
ATOM   2702 C  C     . TYR A 1 719  ? 163.271 178.905 155.796 1.00 87.58  ? 1064 TYR A C     1 
ATOM   2703 O  O     . TYR A 1 719  ? 164.151 178.221 156.325 1.00 92.01  ? 1064 TYR A O     1 
ATOM   2704 C  CB    . TYR A 1 719  ? 162.646 180.836 157.263 1.00 80.48  ? 1064 TYR A CB    1 
ATOM   2705 C  CG    . TYR A 1 719  ? 162.856 181.975 156.295 1.00 81.61  ? 1064 TYR A CG    1 
ATOM   2706 C  CD1   . TYR A 1 719  ? 161.782 182.682 155.782 1.00 81.30  ? 1064 TYR A CD1   1 
ATOM   2707 C  CD2   . TYR A 1 719  ? 164.131 182.348 155.902 1.00 83.74  ? 1064 TYR A CD2   1 
ATOM   2708 C  CE1   . TYR A 1 719  ? 161.972 183.727 154.901 1.00 82.85  ? 1064 TYR A CE1   1 
ATOM   2709 C  CE2   . TYR A 1 719  ? 164.331 183.390 155.022 1.00 83.86  ? 1064 TYR A CE2   1 
ATOM   2710 C  CZ    . TYR A 1 719  ? 163.248 184.075 154.524 1.00 83.28  ? 1064 TYR A CZ    1 
ATOM   2711 O  OH    . TYR A 1 719  ? 163.446 185.114 153.645 1.00 85.32  ? 1064 TYR A OH    1 
ATOM   2712 N  N     . GLY A 1 720  ? 163.220 179.131 154.482 1.00 88.32  ? 1065 GLY A N     1 
ATOM   2713 C  CA    . GLY A 1 720  ? 164.161 178.470 153.591 1.00 85.94  ? 1065 GLY A CA    1 
ATOM   2714 C  C     . GLY A 1 720  ? 165.600 178.884 153.835 1.00 91.56  ? 1065 GLY A C     1 
ATOM   2715 O  O     . GLY A 1 720  ? 166.498 178.042 153.902 1.00 93.55  ? 1065 GLY A O     1 
ATOM   2716 N  N     . GLU A 1 721  ? 165.839 180.186 153.969 1.00 108.90 ? 1066 GLU A N     1 
ATOM   2717 C  CA    . GLU A 1 721  ? 167.187 180.700 154.170 1.00 110.46 ? 1066 GLU A CA    1 
ATOM   2718 C  C     . GLU A 1 721  ? 167.627 180.680 155.628 1.00 109.84 ? 1066 GLU A C     1 
ATOM   2719 O  O     . GLU A 1 721  ? 168.812 180.900 155.902 1.00 111.28 ? 1066 GLU A O     1 
ATOM   2720 C  CB    . GLU A 1 721  ? 167.296 182.129 153.628 1.00 111.22 ? 1066 GLU A CB    1 
ATOM   2721 C  CG    . GLU A 1 721  ? 167.884 182.223 152.229 1.00 110.24 ? 1066 GLU A CG    1 
ATOM   2722 C  CD    . GLU A 1 721  ? 169.400 182.191 152.229 1.00 109.55 ? 1066 GLU A CD    1 
ATOM   2723 O  OE1   . GLU A 1 721  ? 170.000 182.329 153.316 1.00 109.48 ? 1066 GLU A OE1   1 
ATOM   2724 O  OE2   . GLU A 1 721  ? 169.994 182.031 151.142 1.00 108.28 ? 1066 GLU A OE2   1 
ATOM   2725 N  N     . ASP A 1 722  ? 166.710 180.430 156.565 1.00 113.73 ? 1067 ASP A N     1 
ATOM   2726 C  CA    . ASP A 1 722  ? 167.086 180.369 157.974 1.00 114.62 ? 1067 ASP A CA    1 
ATOM   2727 C  C     . ASP A 1 722  ? 168.020 179.197 158.248 1.00 116.70 ? 1067 ASP A C     1 
ATOM   2728 O  O     . ASP A 1 722  ? 168.976 179.326 159.022 1.00 116.52 ? 1067 ASP A O     1 
ATOM   2729 C  CB    . ASP A 1 722  ? 165.835 180.272 158.846 1.00 116.16 ? 1067 ASP A CB    1 
ATOM   2730 C  CG    . ASP A 1 722  ? 166.154 180.286 160.328 1.00 120.20 ? 1067 ASP A CG    1 
ATOM   2731 O  OD1   . ASP A 1 722  ? 167.198 180.855 160.708 1.00 120.95 ? 1067 ASP A OD1   1 
ATOM   2732 O  OD2   . ASP A 1 722  ? 165.361 179.726 161.113 1.00 118.84 ? 1067 ASP A OD2   1 
ATOM   2733 N  N     . LEU A 1 723  ? 167.758 178.053 157.631 1.00 120.06 ? 1068 LEU A N     1 
ATOM   2734 C  CA    . LEU A 1 723  ? 168.582 176.873 157.862 1.00 122.75 ? 1068 LEU A CA    1 
ATOM   2735 C  C     . LEU A 1 723  ? 169.985 177.094 157.308 1.00 124.87 ? 1068 LEU A C     1 
ATOM   2736 O  O     . LEU A 1 723  ? 170.130 177.533 156.161 1.00 125.12 ? 1068 LEU A O     1 
ATOM   2737 C  CB    . LEU A 1 723  ? 167.948 175.649 157.209 1.00 121.92 ? 1068 LEU A CB    1 
ATOM   2738 C  CG    . LEU A 1 723  ? 166.566 175.255 157.722 1.00 120.64 ? 1068 LEU A CG    1 
ATOM   2739 C  CD1   . LEU A 1 723  ? 165.765 174.599 156.617 1.00 120.81 ? 1068 LEU A CD1   1 
ATOM   2740 C  CD2   . LEU A 1 723  ? 166.689 174.330 158.920 1.00 121.36 ? 1068 LEU A CD2   1 
ATOM   2741 N  N     . PRO A 1 724  ? 171.034 176.818 158.085 1.00 128.88 ? 1069 PRO A N     1 
ATOM   2742 C  CA    . PRO A 1 724  ? 172.395 176.929 157.536 1.00 128.92 ? 1069 PRO A CA    1 
ATOM   2743 C  C     . PRO A 1 724  ? 172.645 176.003 156.360 1.00 129.83 ? 1069 PRO A C     1 
ATOM   2744 O  O     . PRO A 1 724  ? 173.383 176.371 155.437 1.00 128.54 ? 1069 PRO A O     1 
ATOM   2745 C  CB    . PRO A 1 724  ? 173.287 176.577 158.736 1.00 128.56 ? 1069 PRO A CB    1 
ATOM   2746 C  CG    . PRO A 1 724  ? 172.404 175.798 159.659 1.00 126.55 ? 1069 PRO A CG    1 
ATOM   2747 C  CD    . PRO A 1 724  ? 171.031 176.369 159.487 1.00 125.60 ? 1069 PRO A CD    1 
ATOM   2748 N  N     . GLU A 1 725  ? 172.051 174.813 156.362 1.00 127.90 ? 1070 GLU A N     1 
ATOM   2749 C  CA    . GLU A 1 725  ? 172.224 173.877 155.265 1.00 126.41 ? 1070 GLU A CA    1 
ATOM   2750 C  C     . GLU A 1 725  ? 171.259 174.197 154.127 1.00 127.09 ? 1070 GLU A C     1 
ATOM   2751 O  O     . GLU A 1 725  ? 170.274 174.922 154.294 1.00 127.25 ? 1070 GLU A O     1 
ATOM   2752 C  CB    . GLU A 1 725  ? 172.011 172.441 155.745 1.00 127.11 ? 1070 GLU A CB    1 
ATOM   2753 C  CG    . GLU A 1 725  ? 170.867 172.280 156.731 1.00 126.37 ? 1070 GLU A CG    1 
ATOM   2754 C  CD    . GLU A 1 725  ? 170.722 170.856 157.228 1.00 128.42 ? 1070 GLU A CD    1 
ATOM   2755 O  OE1   . GLU A 1 725  ? 171.512 169.990 156.796 1.00 127.41 ? 1070 GLU A OE1   1 
ATOM   2756 O  OE2   . GLU A 1 725  ? 169.818 170.601 158.050 1.00 128.72 ? 1070 GLU A OE2   1 
ATOM   2757 N  N     . CYS A 1 726  ? 171.559 173.646 152.955 1.00 120.89 ? 1071 CYS A N     1 
ATOM   2758 C  CA    . CYS A 1 726  ? 170.711 173.853 151.791 1.00 121.46 ? 1071 CYS A CA    1 
ATOM   2759 C  C     . CYS A 1 726  ? 169.382 173.123 151.957 1.00 122.44 ? 1071 CYS A C     1 
ATOM   2760 O  O     . CYS A 1 726  ? 169.296 172.079 152.609 1.00 121.52 ? 1071 CYS A O     1 
ATOM   2761 C  CB    . CYS A 1 726  ? 171.416 173.376 150.522 1.00 119.94 ? 1071 CYS A CB    1 
ATOM   2762 S  SG    . CYS A 1 726  ? 171.945 171.650 150.566 1.00 123.07 ? 1071 CYS A SG    1 
ATOM   2763 N  N     . VAL A 1 727  ? 168.335 173.693 151.355 1.00 107.82 ? 1072 VAL A N     1 
ATOM   2764 C  CA    . VAL A 1 727  ? 167.002 173.112 151.450 1.00 105.11 ? 1072 VAL A CA    1 
ATOM   2765 C  C     . VAL A 1 727  ? 166.921 171.750 150.776 1.00 103.84 ? 1072 VAL A C     1 
ATOM   2766 O  O     . VAL A 1 727  ? 166.050 170.946 151.124 1.00 103.54 ? 1072 VAL A O     1 
ATOM   2767 C  CB    . VAL A 1 727  ? 165.956 174.069 150.850 1.00 101.54 ? 1072 VAL A CB    1 
ATOM   2768 C  CG1   . VAL A 1 727  ? 165.836 175.320 151.702 1.00 101.73 ? 1072 VAL A CG1   1 
ATOM   2769 C  CG2   . VAL A 1 727  ? 166.325 174.426 149.421 1.00 101.18 ? 1072 VAL A CG2   1 
ATOM   2770 N  N     . GLN A 1 728  ? 167.801 171.471 149.811 1.00 106.22 ? 1073 GLN A N     1 
ATOM   2771 C  CA    . GLN A 1 728  ? 167.785 170.170 149.150 1.00 107.87 ? 1073 GLN A CA    1 
ATOM   2772 C  C     . GLN A 1 728  ? 168.086 169.046 150.135 1.00 110.06 ? 1073 GLN A C     1 
ATOM   2773 O  O     . GLN A 1 728  ? 167.416 168.007 150.128 1.00 107.79 ? 1073 GLN A O     1 
ATOM   2774 C  CB    . GLN A 1 728  ? 168.786 170.158 147.996 1.00 105.96 ? 1073 GLN A CB    1 
ATOM   2775 C  CG    . GLN A 1 728  ? 169.164 171.541 147.487 1.00 106.38 ? 1073 GLN A CG    1 
ATOM   2776 C  CD    . GLN A 1 728  ? 168.070 172.177 146.650 1.00 107.86 ? 1073 GLN A CD    1 
ATOM   2777 O  OE1   . GLN A 1 728  ? 167.265 171.484 146.029 1.00 106.54 ? 1073 GLN A OE1   1 
ATOM   2778 N  NE2   . GLN A 1 728  ? 168.035 173.504 146.632 1.00 108.25 ? 1073 GLN A NE2   1 
ATOM   2779 N  N     . VAL A 1 729  ? 169.095 169.235 150.986 1.00 114.19 ? 1074 VAL A N     1 
ATOM   2780 C  CA    . VAL A 1 729  ? 169.386 168.256 152.028 1.00 112.91 ? 1074 VAL A CA    1 
ATOM   2781 C  C     . VAL A 1 729  ? 168.305 168.284 153.102 1.00 112.06 ? 1074 VAL A C     1 
ATOM   2782 O  O     . VAL A 1 729  ? 167.910 167.239 153.635 1.00 112.63 ? 1074 VAL A O     1 
ATOM   2783 C  CB    . VAL A 1 729  ? 170.786 168.511 152.618 1.00 111.70 ? 1074 VAL A CB    1 
ATOM   2784 C  CG1   . VAL A 1 729  ? 170.992 167.702 153.889 1.00 111.61 ? 1074 VAL A CG1   1 
ATOM   2785 C  CG2   . VAL A 1 729  ? 171.859 168.180 151.593 1.00 113.19 ? 1074 VAL A CG2   1 
ATOM   2786 N  N     . TYR A 1 730  ? 167.808 169.479 153.432 1.00 98.57  ? 1075 TYR A N     1 
ATOM   2787 C  CA    . TYR A 1 730  ? 166.807 169.616 154.486 1.00 97.00  ? 1075 TYR A CA    1 
ATOM   2788 C  C     . TYR A 1 730  ? 165.534 168.848 154.153 1.00 99.50  ? 1075 TYR A C     1 
ATOM   2789 O  O     . TYR A 1 730  ? 164.893 168.279 155.045 1.00 97.87  ? 1075 TYR A O     1 
ATOM   2790 C  CB    . TYR A 1 730  ? 166.492 171.094 154.713 1.00 95.79  ? 1075 TYR A CB    1 
ATOM   2791 C  CG    . TYR A 1 730  ? 165.230 171.336 155.505 1.00 99.01  ? 1075 TYR A CG    1 
ATOM   2792 C  CD1   . TYR A 1 730  ? 165.112 170.890 156.813 1.00 101.10 ? 1075 TYR A CD1   1 
ATOM   2793 C  CD2   . TYR A 1 730  ? 164.152 172.003 154.941 1.00 97.07  ? 1075 TYR A CD2   1 
ATOM   2794 C  CE1   . TYR A 1 730  ? 163.960 171.108 157.539 1.00 98.37  ? 1075 TYR A CE1   1 
ATOM   2795 C  CE2   . TYR A 1 730  ? 162.996 172.226 155.660 1.00 96.29  ? 1075 TYR A CE2   1 
ATOM   2796 C  CZ    . TYR A 1 730  ? 162.906 171.774 156.958 1.00 95.80  ? 1075 TYR A CZ    1 
ATOM   2797 O  OH    . TYR A 1 730  ? 161.757 171.989 157.681 1.00 97.65  ? 1075 TYR A OH    1 
ATOM   2798 N  N     . SER A 1 731  ? 165.150 168.825 152.875 1.00 99.54  ? 1076 SER A N     1 
ATOM   2799 C  CA    . SER A 1 731  ? 163.919 168.148 152.482 1.00 98.44  ? 1076 SER A CA    1 
ATOM   2800 C  C     . SER A 1 731  ? 163.978 166.659 152.803 1.00 99.55  ? 1076 SER A C     1 
ATOM   2801 O  O     . SER A 1 731  ? 162.990 166.076 153.263 1.00 99.57  ? 1076 SER A O     1 
ATOM   2802 C  CB    . SER A 1 731  ? 163.657 168.371 150.994 1.00 98.07  ? 1076 SER A CB    1 
ATOM   2803 O  OG    . SER A 1 731  ? 163.595 169.754 150.693 1.00 98.79  ? 1076 SER A OG    1 
ATOM   2804 N  N     . MET A 1 732  ? 165.126 166.028 152.572 1.00 106.36 ? 1077 MET A N     1 
ATOM   2805 C  CA    . MET A 1 732  ? 165.321 164.625 152.907 1.00 105.69 ? 1077 MET A CA    1 
ATOM   2806 C  C     . MET A 1 732  ? 165.869 164.469 154.325 1.00 106.17 ? 1077 MET A C     1 
ATOM   2807 O  O     . MET A 1 732  ? 166.212 163.358 154.734 1.00 107.02 ? 1077 MET A O     1 
ATOM   2808 C  CB    . MET A 1 732  ? 166.276 163.979 151.890 1.00 104.76 ? 1077 MET A CB    1 
ATOM   2809 C  CG    . MET A 1 732  ? 166.389 162.443 151.886 1.00 107.99 ? 1077 MET A CG    1 
ATOM   2810 S  SD    . MET A 1 732  ? 164.809 161.549 151.953 1.00 115.16 ? 1077 MET A SD    1 
ATOM   2811 C  CE    . MET A 1 732  ? 164.693 161.008 153.654 1.00 105.42 ? 1077 MET A CE    1 
ATOM   2812 N  N     . GLY A 1 733  ? 165.980 165.566 155.076 1.00 99.63  ? 1078 GLY A N     1 
ATOM   2813 C  CA    . GLY A 1 733  ? 166.482 165.469 156.436 1.00 99.13  ? 1078 GLY A CA    1 
ATOM   2814 C  C     . GLY A 1 733  ? 165.566 164.672 157.346 1.00 100.20 ? 1078 GLY A C     1 
ATOM   2815 O  O     . GLY A 1 733  ? 166.028 163.990 158.265 1.00 99.91  ? 1078 GLY A O     1 
ATOM   2816 N  N     . GLY A 1 734  ? 164.261 164.753 157.112 1.00 94.86  ? 1079 GLY A N     1 
ATOM   2817 C  CA    . GLY A 1 734  ? 163.301 164.011 157.890 1.00 92.99  ? 1079 GLY A CA    1 
ATOM   2818 C  C     . GLY A 1 734  ? 161.920 164.053 157.272 1.00 94.13  ? 1079 GLY A C     1 
ATOM   2819 O  O     . GLY A 1 734  ? 161.625 164.883 156.407 1.00 95.71  ? 1079 GLY A O     1 
ATOM   2820 N  N     . PRO A 1 735  ? 161.046 163.146 157.697 1.00 94.34  ? 1080 PRO A N     1 
ATOM   2821 C  CA    . PRO A 1 735  ? 159.681 163.137 157.165 1.00 90.88  ? 1080 PRO A CA    1 
ATOM   2822 C  C     . PRO A 1 735  ? 158.889 164.341 157.644 1.00 93.26  ? 1080 PRO A C     1 
ATOM   2823 O  O     . PRO A 1 735  ? 159.147 164.899 158.714 1.00 95.30  ? 1080 PRO A O     1 
ATOM   2824 C  CB    . PRO A 1 735  ? 159.097 161.833 157.716 1.00 92.95  ? 1080 PRO A CB    1 
ATOM   2825 C  CG    . PRO A 1 735  ? 159.861 161.594 158.972 1.00 94.10  ? 1080 PRO A CG    1 
ATOM   2826 C  CD    . PRO A 1 735  ? 161.251 162.110 158.723 1.00 95.01  ? 1080 PRO A CD    1 
ATOM   2827 N  N     . ASN A 1 736  ? 157.911 164.738 156.828 1.00 77.41  ? 1081 ASN A N     1 
ATOM   2828 C  CA    . ASN A 1 736  ? 156.996 165.833 157.146 1.00 74.12  ? 1081 ASN A CA    1 
ATOM   2829 C  C     . ASN A 1 736  ? 157.755 167.143 157.364 1.00 72.55  ? 1081 ASN A C     1 
ATOM   2830 O  O     . ASN A 1 736  ? 157.678 167.773 158.420 1.00 73.73  ? 1081 ASN A O     1 
ATOM   2831 C  CB    . ASN A 1 736  ? 156.135 165.486 158.365 1.00 71.43  ? 1081 ASN A CB    1 
ATOM   2832 C  CG    . ASN A 1 736  ? 155.503 164.115 158.258 1.00 77.11  ? 1081 ASN A CG    1 
ATOM   2833 O  OD1   . ASN A 1 736  ? 155.396 163.551 157.170 1.00 79.99  ? 1081 ASN A OD1   1 
ATOM   2834 N  ND2   . ASN A 1 736  ? 155.081 163.570 159.392 1.00 75.95  ? 1081 ASN A ND2   1 
ATOM   2835 N  N     . ARG A 1 737  ? 158.498 167.546 156.336 1.00 72.70  ? 1082 ARG A N     1 
ATOM   2836 C  CA    . ARG A 1 737  ? 159.247 168.794 156.350 1.00 73.43  ? 1082 ARG A CA    1 
ATOM   2837 C  C     . ARG A 1 737  ? 158.824 169.655 155.171 1.00 76.07  ? 1082 ARG A C     1 
ATOM   2838 O  O     . ARG A 1 737  ? 158.867 169.205 154.021 1.00 83.94  ? 1082 ARG A O     1 
ATOM   2839 C  CB    . ARG A 1 737  ? 160.754 168.536 156.299 1.00 72.46  ? 1082 ARG A CB    1 
ATOM   2840 C  CG    . ARG A 1 737  ? 161.303 167.887 157.553 1.00 77.87  ? 1082 ARG A CG    1 
ATOM   2841 C  CD    . ARG A 1 737  ? 162.817 167.855 157.549 1.00 75.32  ? 1082 ARG A CD    1 
ATOM   2842 N  NE    . ARG A 1 737  ? 163.344 167.225 158.753 1.00 81.39  ? 1082 ARG A NE    1 
ATOM   2843 C  CZ    . ARG A 1 737  ? 164.608 167.299 159.145 1.00 84.13  ? 1082 ARG A CZ    1 
ATOM   2844 N  NH1   . ARG A 1 737  ? 165.508 167.977 158.452 1.00 83.10  ? 1082 ARG A NH1   1 
ATOM   2845 N  NH2   . ARG A 1 737  ? 164.979 166.677 160.260 1.00 81.83  ? 1082 ARG A NH2   1 
ATOM   2846 N  N     . PHE A 1 738  ? 158.423 170.890 155.460 1.00 47.04  ? 1083 PHE A N     1 
ATOM   2847 C  CA    . PHE A 1 738  ? 158.045 171.863 154.448 1.00 42.30  ? 1083 PHE A CA    1 
ATOM   2848 C  C     . PHE A 1 738  ? 158.853 173.131 154.669 1.00 45.34  ? 1083 PHE A C     1 
ATOM   2849 O  O     . PHE A 1 738  ? 159.338 173.394 155.771 1.00 59.28  ? 1083 PHE A O     1 
ATOM   2850 C  CB    . PHE A 1 738  ? 156.547 172.186 154.501 1.00 46.45  ? 1083 PHE A CB    1 
ATOM   2851 C  CG    . PHE A 1 738  ? 155.662 171.039 154.119 1.00 43.24  ? 1083 PHE A CG    1 
ATOM   2852 C  CD1   . PHE A 1 738  ? 155.381 170.035 155.023 1.00 41.94  ? 1083 PHE A CD1   1 
ATOM   2853 C  CD2   . PHE A 1 738  ? 155.095 170.974 152.861 1.00 47.18  ? 1083 PHE A CD2   1 
ATOM   2854 C  CE1   . PHE A 1 738  ? 154.564 168.984 154.676 1.00 40.47  ? 1083 PHE A CE1   1 
ATOM   2855 C  CE2   . PHE A 1 738  ? 154.275 169.927 152.511 1.00 45.46  ? 1083 PHE A CE2   1 
ATOM   2856 C  CZ    . PHE A 1 738  ? 154.009 168.931 153.420 1.00 48.04  ? 1083 PHE A CZ    1 
ATOM   2857 N  N     . TYR A 1 739  ? 159.005 173.921 153.611 1.00 34.72  ? 1084 TYR A N     1 
ATOM   2858 C  CA    . TYR A 1 739  ? 159.755 175.163 153.712 1.00 40.98  ? 1084 TYR A CA    1 
ATOM   2859 C  C     . TYR A 1 739  ? 159.113 176.229 152.841 1.00 49.18  ? 1084 TYR A C     1 
ATOM   2860 O  O     . TYR A 1 739  ? 158.523 175.933 151.801 1.00 61.95  ? 1084 TYR A O     1 
ATOM   2861 C  CB    . TYR A 1 739  ? 161.223 174.969 153.313 1.00 51.95  ? 1084 TYR A CB    1 
ATOM   2862 C  CG    . TYR A 1 739  ? 161.491 175.075 151.830 1.00 56.84  ? 1084 TYR A CG    1 
ATOM   2863 C  CD1   . TYR A 1 739  ? 161.119 174.060 150.963 1.00 54.52  ? 1084 TYR A CD1   1 
ATOM   2864 C  CD2   . TYR A 1 739  ? 162.132 176.184 151.300 1.00 56.49  ? 1084 TYR A CD2   1 
ATOM   2865 C  CE1   . TYR A 1 739  ? 161.369 174.151 149.613 1.00 42.31  ? 1084 TYR A CE1   1 
ATOM   2866 C  CE2   . TYR A 1 739  ? 162.385 176.283 149.951 1.00 50.42  ? 1084 TYR A CE2   1 
ATOM   2867 C  CZ    . TYR A 1 739  ? 162.002 175.264 149.113 1.00 42.22  ? 1084 TYR A CZ    1 
ATOM   2868 O  OH    . TYR A 1 739  ? 162.253 175.362 147.766 1.00 54.33  ? 1084 TYR A OH    1 
ATOM   2869 N  N     . PHE A 1 740  ? 159.238 177.478 153.282 1.00 53.58  ? 1085 PHE A N     1 
ATOM   2870 C  CA    . PHE A 1 740  ? 158.725 178.632 152.561 1.00 48.26  ? 1085 PHE A CA    1 
ATOM   2871 C  C     . PHE A 1 740  ? 159.847 179.640 152.379 1.00 54.49  ? 1085 PHE A C     1 
ATOM   2872 O  O     . PHE A 1 740  ? 160.739 179.745 153.225 1.00 64.20  ? 1085 PHE A O     1 
ATOM   2873 C  CB    . PHE A 1 740  ? 157.546 179.277 153.298 1.00 52.11  ? 1085 PHE A CB    1 
ATOM   2874 C  CG    . PHE A 1 740  ? 157.945 180.073 154.506 1.00 56.61  ? 1085 PHE A CG    1 
ATOM   2875 C  CD1   . PHE A 1 740  ? 158.239 179.444 155.701 1.00 56.68  ? 1085 PHE A CD1   1 
ATOM   2876 C  CD2   . PHE A 1 740  ? 158.016 181.453 154.450 1.00 59.97  ? 1085 PHE A CD2   1 
ATOM   2877 C  CE1   . PHE A 1 740  ? 158.604 180.174 156.811 1.00 57.85  ? 1085 PHE A CE1   1 
ATOM   2878 C  CE2   . PHE A 1 740  ? 158.380 182.187 155.557 1.00 57.16  ? 1085 PHE A CE2   1 
ATOM   2879 C  CZ    . PHE A 1 740  ? 158.674 181.547 156.739 1.00 58.04  ? 1085 PHE A CZ    1 
ATOM   2880 N  N     . LEU A 1 741  ? 159.804 180.378 151.271 1.00 59.26  ? 1086 LEU A N     1 
ATOM   2881 C  CA    . LEU A 1 741  ? 160.855 181.328 150.943 1.00 62.17  ? 1086 LEU A CA    1 
ATOM   2882 C  C     . LEU A 1 741  ? 160.357 182.733 150.644 1.00 58.66  ? 1086 LEU A C     1 
ATOM   2883 O  O     . LEU A 1 741  ? 161.149 183.676 150.739 1.00 57.53  ? 1086 LEU A O     1 
ATOM   2884 C  CB    . LEU A 1 741  ? 161.667 180.830 149.737 1.00 62.71  ? 1086 LEU A CB    1 
ATOM   2885 C  CG    . LEU A 1 741  ? 163.127 181.277 149.640 1.00 66.97  ? 1086 LEU A CG    1 
ATOM   2886 C  CD1   . LEU A 1 741  ? 163.733 181.452 151.021 1.00 66.78  ? 1086 LEU A CD1   1 
ATOM   2887 C  CD2   . LEU A 1 741  ? 163.934 180.281 148.825 1.00 63.11  ? 1086 LEU A CD2   1 
ATOM   2888 N  N     . GLU A 1 742  ? 159.086 182.904 150.293 1.00 69.81  ? 1087 GLU A N     1 
ATOM   2889 C  CA    . GLU A 1 742  ? 158.555 184.217 149.957 1.00 70.89  ? 1087 GLU A CA    1 
ATOM   2890 C  C     . GLU A 1 742  ? 157.112 184.304 150.424 1.00 73.01  ? 1087 GLU A C     1 
ATOM   2891 O  O     . GLU A 1 742  ? 156.364 183.329 150.332 1.00 78.45  ? 1087 GLU A O     1 
ATOM   2892 C  CB    . GLU A 1 742  ? 158.638 184.485 148.451 1.00 74.62  ? 1087 GLU A CB    1 
ATOM   2893 C  CG    . GLU A 1 742  ? 160.008 184.938 147.975 1.00 79.21  ? 1087 GLU A CG    1 
ATOM   2894 C  CD    . GLU A 1 742  ? 160.080 185.090 146.470 1.00 81.68  ? 1087 GLU A CD    1 
ATOM   2895 O  OE1   . GLU A 1 742  ? 159.361 184.355 145.762 1.00 81.69  ? 1087 GLU A OE1   1 
ATOM   2896 O  OE2   . GLU A 1 742  ? 160.857 185.945 145.995 1.00 80.60  ? 1087 GLU A OE2   1 
ATOM   2897 N  N     . ALA A 1 743  ? 156.728 185.475 150.918 1.00 67.14  ? 1088 ALA A N     1 
ATOM   2898 C  CA    . ALA A 1 743  ? 155.379 185.695 151.412 1.00 68.54  ? 1088 ALA A CA    1 
ATOM   2899 C  C     . ALA A 1 743  ? 154.454 186.089 150.272 1.00 65.52  ? 1088 ALA A C     1 
ATOM   2900 O  O     . ALA A 1 743  ? 154.889 186.629 149.254 1.00 74.00  ? 1088 ALA A O     1 
ATOM   2901 C  CB    . ALA A 1 743  ? 155.365 186.780 152.488 1.00 72.73  ? 1088 ALA A CB    1 
ATOM   2902 N  N     . TYR A 1 744  ? 153.164 185.833 150.462 1.00 52.76  ? 1089 TYR A N     1 
ATOM   2903 C  CA    . TYR A 1 744  ? 152.155 186.073 149.443 1.00 59.75  ? 1089 TYR A CA    1 
ATOM   2904 C  C     . TYR A 1 744  ? 151.111 187.052 149.958 1.00 58.72  ? 1089 TYR A C     1 
ATOM   2905 O  O     . TYR A 1 744  ? 150.681 186.965 151.112 1.00 61.12  ? 1089 TYR A O     1 
ATOM   2906 C  CB    . TYR A 1 744  ? 151.483 184.766 149.032 1.00 58.13  ? 1089 TYR A CB    1 
ATOM   2907 C  CG    . TYR A 1 744  ? 150.671 184.853 147.765 1.00 57.79  ? 1089 TYR A CG    1 
ATOM   2908 C  CD1   . TYR A 1 744  ? 151.288 184.922 146.528 1.00 57.47  ? 1089 TYR A CD1   1 
ATOM   2909 C  CD2   . TYR A 1 744  ? 149.287 184.850 147.805 1.00 57.36  ? 1089 TYR A CD2   1 
ATOM   2910 C  CE1   . TYR A 1 744  ? 150.550 184.994 145.369 1.00 52.94  ? 1089 TYR A CE1   1 
ATOM   2911 C  CE2   . TYR A 1 744  ? 148.541 184.923 146.649 1.00 57.96  ? 1089 TYR A CE2   1 
ATOM   2912 C  CZ    . TYR A 1 744  ? 149.178 184.993 145.435 1.00 50.25  ? 1089 TYR A CZ    1 
ATOM   2913 O  OH    . TYR A 1 744  ? 148.441 185.064 144.278 1.00 55.43  ? 1089 TYR A OH    1 
ATOM   2914 N  N     . ASN A 1 745  ? 150.709 187.984 149.099 1.00 63.05  ? 1090 ASN A N     1 
ATOM   2915 C  CA    . ASN A 1 745  ? 149.631 188.921 149.383 1.00 60.62  ? 1090 ASN A CA    1 
ATOM   2916 C  C     . ASN A 1 745  ? 148.521 188.680 148.372 1.00 66.52  ? 1090 ASN A C     1 
ATOM   2917 O  O     . ASN A 1 745  ? 148.736 188.828 147.162 1.00 74.96  ? 1090 ASN A O     1 
ATOM   2918 C  CB    . ASN A 1 745  ? 150.123 190.366 149.314 1.00 62.81  ? 1090 ASN A CB    1 
ATOM   2919 C  CG    . ASN A 1 745  ? 149.130 191.347 149.905 1.00 68.14  ? 1090 ASN A CG    1 
ATOM   2920 O  OD1   . ASN A 1 745  ? 148.003 191.473 149.426 1.00 67.68  ? 1090 ASN A OD1   1 
ATOM   2921 N  ND2   . ASN A 1 745  ? 149.545 192.050 150.951 1.00 69.33  ? 1090 ASN A ND2   1 
ATOM   2922 N  N     . ALA A 1 746  ? 147.342 188.312 148.873 1.00 66.65  ? 1091 ALA A N     1 
ATOM   2923 C  CA    . ALA A 1 746  ? 146.241 187.937 147.993 1.00 70.59  ? 1091 ALA A CA    1 
ATOM   2924 C  C     . ALA A 1 746  ? 145.584 189.159 147.365 1.00 71.42  ? 1091 ALA A C     1 
ATOM   2925 O  O     . ALA A 1 746  ? 145.157 189.110 146.206 1.00 68.09  ? 1091 ALA A O     1 
ATOM   2926 C  CB    . ALA A 1 746  ? 145.212 187.115 148.767 1.00 69.15  ? 1091 ALA A CB    1 
ATOM   2927 N  N     . LYS A 1 747  ? 145.479 190.257 148.116 1.00 78.11  ? 1092 LYS A N     1 
ATOM   2928 C  CA    . LYS A 1 747  ? 144.796 191.441 147.605 1.00 76.18  ? 1092 LYS A CA    1 
ATOM   2929 C  C     . LYS A 1 747  ? 145.518 192.014 146.393 1.00 74.29  ? 1092 LYS A C     1 
ATOM   2930 O  O     . LYS A 1 747  ? 144.893 192.313 145.369 1.00 73.01  ? 1092 LYS A O     1 
ATOM   2931 C  CB    . LYS A 1 747  ? 144.670 192.491 148.709 1.00 73.67  ? 1092 LYS A CB    1 
ATOM   2932 C  CG    . LYS A 1 747  ? 143.274 192.595 149.306 1.00 75.63  ? 1092 LYS A CG    1 
ATOM   2933 C  CD    . LYS A 1 747  ? 142.663 191.220 149.534 1.00 74.55  ? 1092 LYS A CD    1 
ATOM   2934 C  CE    . LYS A 1 747  ? 141.360 191.313 150.311 1.00 76.28  ? 1092 LYS A CE    1 
ATOM   2935 N  NZ    . LYS A 1 747  ? 140.552 190.069 150.189 1.00 75.87  ? 1092 LYS A NZ    1 
ATOM   2936 N  N     . SER A 1 748  ? 146.835 192.170 146.486 1.00 67.17  ? 1093 SER A N     1 
ATOM   2937 C  CA    . SER A 1 748  ? 147.630 192.613 145.351 1.00 63.57  ? 1093 SER A CA    1 
ATOM   2938 C  C     . SER A 1 748  ? 148.165 191.457 144.519 1.00 66.89  ? 1093 SER A C     1 
ATOM   2939 O  O     . SER A 1 748  ? 148.770 191.702 143.470 1.00 70.01  ? 1093 SER A O     1 
ATOM   2940 C  CB    . SER A 1 748  ? 148.799 193.483 145.827 1.00 64.48  ? 1093 SER A CB    1 
ATOM   2941 O  OG    . SER A 1 748  ? 149.670 192.753 146.670 1.00 65.95  ? 1093 SER A OG    1 
ATOM   2942 N  N     . LYS A 1 749  ? 147.948 190.216 144.957 1.00 69.34  ? 1094 LYS A N     1 
ATOM   2943 C  CA    . LYS A 1 749  ? 148.424 189.025 144.255 1.00 68.29  ? 1094 LYS A CA    1 
ATOM   2944 C  C     . LYS A 1 749  ? 149.921 189.119 143.973 1.00 70.27  ? 1094 LYS A C     1 
ATOM   2945 O  O     . LYS A 1 749  ? 150.383 188.912 142.849 1.00 72.09  ? 1094 LYS A O     1 
ATOM   2946 C  CB    . LYS A 1 749  ? 147.637 188.804 142.963 1.00 66.45  ? 1094 LYS A CB    1 
ATOM   2947 C  CG    . LYS A 1 749  ? 146.137 188.743 143.159 1.00 68.56  ? 1094 LYS A CG    1 
ATOM   2948 C  CD    . LYS A 1 749  ? 145.406 188.816 141.832 1.00 71.61  ? 1094 LYS A CD    1 
ATOM   2949 C  CE    . LYS A 1 749  ? 143.909 188.967 142.038 1.00 73.88  ? 1094 LYS A CE    1 
ATOM   2950 N  NZ    . LYS A 1 749  ? 143.250 187.659 142.300 1.00 77.87  ? 1094 LYS A NZ    1 
ATOM   2951 N  N     . SER A 1 750  ? 150.690 189.441 145.010 1.00 66.63  ? 1095 SER A N     1 
ATOM   2952 C  CA    . SER A 1 750  ? 152.102 189.744 144.832 1.00 60.99  ? 1095 SER A CA    1 
ATOM   2953 C  C     . SER A 1 750  ? 152.952 189.001 145.850 1.00 61.08  ? 1095 SER A C     1 
ATOM   2954 O  O     . SER A 1 750  ? 152.504 188.688 146.954 1.00 65.58  ? 1095 SER A O     1 
ATOM   2955 C  CB    . SER A 1 750  ? 152.364 191.248 144.946 1.00 65.66  ? 1095 SER A CB    1 
ATOM   2956 O  OG    . SER A 1 750  ? 151.655 191.804 146.039 1.00 70.17  ? 1095 SER A OG    1 
ATOM   2957 N  N     . PHE A 1 751  ? 154.197 188.736 145.469 1.00 59.34  ? 1096 PHE A N     1 
ATOM   2958 C  CA    . PHE A 1 751  ? 155.152 188.046 146.324 1.00 63.90  ? 1096 PHE A CA    1 
ATOM   2959 C  C     . PHE A 1 751  ? 156.089 189.063 146.960 1.00 68.38  ? 1096 PHE A C     1 
ATOM   2960 O  O     . PHE A 1 751  ? 156.697 189.878 146.259 1.00 72.13  ? 1096 PHE A O     1 
ATOM   2961 C  CB    . PHE A 1 751  ? 155.956 187.016 145.529 1.00 66.91  ? 1096 PHE A CB    1 
ATOM   2962 C  CG    . PHE A 1 751  ? 155.118 185.941 144.901 1.00 66.14  ? 1096 PHE A CG    1 
ATOM   2963 C  CD1   . PHE A 1 751  ? 154.546 186.126 143.657 1.00 69.32  ? 1096 PHE A CD1   1 
ATOM   2964 C  CD2   . PHE A 1 751  ? 154.912 184.740 145.551 1.00 62.49  ? 1096 PHE A CD2   1 
ATOM   2965 C  CE1   . PHE A 1 751  ? 153.781 185.137 143.080 1.00 66.70  ? 1096 PHE A CE1   1 
ATOM   2966 C  CE2   . PHE A 1 751  ? 154.148 183.748 144.976 1.00 61.15  ? 1096 PHE A CE2   1 
ATOM   2967 C  CZ    . PHE A 1 751  ? 153.582 183.948 143.741 1.00 61.45  ? 1096 PHE A CZ    1 
ATOM   2968 N  N     . GLU A 1 752  ? 156.202 189.011 148.280 1.00 79.17  ? 1097 GLU A N     1 
ATOM   2969 C  CA    . GLU A 1 752  ? 157.042 189.919 149.047 1.00 76.56  ? 1097 GLU A CA    1 
ATOM   2970 C  C     . GLU A 1 752  ? 158.018 189.122 149.904 1.00 81.49  ? 1097 GLU A C     1 
ATOM   2971 O  O     . GLU A 1 752  ? 157.997 187.889 149.936 1.00 86.65  ? 1097 GLU A O     1 
ATOM   2972 C  CB    . GLU A 1 752  ? 156.199 190.838 149.936 1.00 72.97  ? 1097 GLU A CB    1 
ATOM   2973 C  CG    . GLU A 1 752  ? 155.025 191.500 149.247 1.00 79.33  ? 1097 GLU A CG    1 
ATOM   2974 C  CD    . GLU A 1 752  ? 153.837 191.667 150.174 1.00 81.93  ? 1097 GLU A CD    1 
ATOM   2975 O  OE1   . GLU A 1 752  ? 153.938 191.253 151.347 1.00 81.08  ? 1097 GLU A OE1   1 
ATOM   2976 O  OE2   . GLU A 1 752  ? 152.805 192.213 149.732 1.00 82.91  ? 1097 GLU A OE2   1 
ATOM   2977 N  N     . ASP A 1 753  ? 158.877 189.847 150.600 1.00 87.70  ? 1098 ASP A N     1 
ATOM   2978 C  CA    . ASP A 1 753  ? 159.743 189.267 151.614 1.00 89.17  ? 1098 ASP A CA    1 
ATOM   2979 C  C     . ASP A 1 753  ? 158.929 188.995 152.879 1.00 88.81  ? 1098 ASP A C     1 
ATOM   2980 O  O     . ASP A 1 753  ? 158.269 189.901 153.395 1.00 92.23  ? 1098 ASP A O     1 
ATOM   2981 C  CB    . ASP A 1 753  ? 160.902 190.220 151.922 1.00 90.09  ? 1098 ASP A CB    1 
ATOM   2982 C  CG    . ASP A 1 753  ? 161.943 189.619 152.856 1.00 93.43  ? 1098 ASP A CG    1 
ATOM   2983 O  OD1   . ASP A 1 753  ? 163.017 190.238 153.006 1.00 96.46  ? 1098 ASP A OD1   1 
ATOM   2984 O  OD2   . ASP A 1 753  ? 161.710 188.540 153.434 1.00 91.09  ? 1098 ASP A OD2   1 
ATOM   2985 N  N     . PRO A 1 754  ? 158.933 187.760 153.378 1.00 81.74  ? 1099 PRO A N     1 
ATOM   2986 C  CA    . PRO A 1 754  ? 158.188 187.468 154.596 1.00 83.30  ? 1099 PRO A CA    1 
ATOM   2987 C  C     . PRO A 1 754  ? 158.663 188.341 155.740 1.00 87.42  ? 1099 PRO A C     1 
ATOM   2988 O  O     . PRO A 1 754  ? 159.864 188.646 155.855 1.00 89.53  ? 1099 PRO A O     1 
ATOM   2989 C  CB    . PRO A 1 754  ? 158.496 185.986 154.850 1.00 83.74  ? 1099 PRO A CB    1 
ATOM   2990 C  CG    . PRO A 1 754  ? 158.755 185.438 153.501 1.00 82.98  ? 1099 PRO A CG    1 
ATOM   2991 C  CD    . PRO A 1 754  ? 159.439 186.535 152.735 1.00 83.54  ? 1099 PRO A CD    1 
ATOM   2992 N  N     . PRO A 1 755  ? 157.751 188.771 156.608 1.00 92.72  ? 1100 PRO A N     1 
ATOM   2993 C  CA    . PRO A 1 755  ? 158.117 189.716 157.670 1.00 94.27  ? 1100 PRO A CA    1 
ATOM   2994 C  C     . PRO A 1 755  ? 159.098 189.108 158.662 1.00 94.41  ? 1100 PRO A C     1 
ATOM   2995 O  O     . PRO A 1 755  ? 159.413 187.917 158.636 1.00 94.07  ? 1100 PRO A O     1 
ATOM   2996 C  CB    . PRO A 1 755  ? 156.777 190.042 158.336 1.00 95.66  ? 1100 PRO A CB    1 
ATOM   2997 C  CG    . PRO A 1 755  ? 155.874 188.914 157.959 1.00 92.39  ? 1100 PRO A CG    1 
ATOM   2998 C  CD    . PRO A 1 755  ? 156.311 188.473 156.602 1.00 90.89  ? 1100 PRO A CD    1 
ATOM   2999 N  N     . ASN A 1 756  ? 159.585 189.972 159.556 1.00 102.49 ? 1101 ASN A N     1 
ATOM   3000 C  CA    . ASN A 1 756  ? 160.640 189.576 160.483 1.00 103.98 ? 1101 ASN A CA    1 
ATOM   3001 C  C     . ASN A 1 756  ? 160.170 188.500 161.453 1.00 103.46 ? 1101 ASN A C     1 
ATOM   3002 O  O     . ASN A 1 756  ? 160.915 187.559 161.748 1.00 104.41 ? 1101 ASN A O     1 
ATOM   3003 C  CB    . ASN A 1 756  ? 161.149 190.797 161.246 1.00 105.60 ? 1101 ASN A CB    1 
ATOM   3004 C  CG    . ASN A 1 756  ? 162.641 191.004 161.082 1.00 106.57 ? 1101 ASN A CG    1 
ATOM   3005 O  OD1   . ASN A 1 756  ? 163.183 190.855 159.987 1.00 104.59 ? 1101 ASN A OD1   1 
ATOM   3006 N  ND2   . ASN A 1 756  ? 163.314 191.349 162.173 1.00 106.77 ? 1101 ASN A ND2   1 
ATOM   3007 N  N     . HIS A 1 757  ? 158.943 188.619 161.967 1.00 101.79 ? 1102 HIS A N     1 
ATOM   3008 C  CA    . HIS A 1 757  ? 158.472 187.647 162.948 1.00 103.71 ? 1102 HIS A CA    1 
ATOM   3009 C  C     . HIS A 1 757  ? 158.209 186.281 162.332 1.00 105.99 ? 1102 HIS A C     1 
ATOM   3010 O  O     . HIS A 1 757  ? 158.194 185.282 163.058 1.00 107.11 ? 1102 HIS A O     1 
ATOM   3011 C  CB    . HIS A 1 757  ? 157.211 188.156 163.649 1.00 101.76 ? 1102 HIS A CB    1 
ATOM   3012 C  CG    . HIS A 1 757  ? 156.064 188.418 162.725 1.00 101.23 ? 1102 HIS A CG    1 
ATOM   3013 N  ND1   . HIS A 1 757  ? 156.005 189.526 161.907 1.00 104.21 ? 1102 HIS A ND1   1 
ATOM   3014 C  CD2   . HIS A 1 757  ? 154.927 187.720 162.496 1.00 99.89  ? 1102 HIS A CD2   1 
ATOM   3015 C  CE1   . HIS A 1 757  ? 154.881 189.497 161.213 1.00 105.49 ? 1102 HIS A CE1   1 
ATOM   3016 N  NE2   . HIS A 1 757  ? 154.210 188.411 161.551 1.00 105.43 ? 1102 HIS A NE2   1 
ATOM   3017 N  N     . ALA A 1 758  ? 158.000 186.210 161.017 1.00 98.37  ? 1103 ALA A N     1 
ATOM   3018 C  CA    . ALA A 1 758  ? 157.854 184.921 160.356 1.00 90.81  ? 1103 ALA A CA    1 
ATOM   3019 C  C     . ALA A 1 758  ? 159.181 184.196 160.201 1.00 92.03  ? 1103 ALA A C     1 
ATOM   3020 O  O     . ALA A 1 758  ? 159.187 182.980 159.986 1.00 94.66  ? 1103 ALA A O     1 
ATOM   3021 C  CB    . ALA A 1 758  ? 157.204 185.097 158.984 1.00 89.45  ? 1103 ALA A CB    1 
ATOM   3022 N  N     . ARG A 1 759  ? 160.300 184.915 160.299 1.00 104.10 ? 1104 ARG A N     1 
ATOM   3023 C  CA    . ARG A 1 759  ? 161.607 184.281 160.166 1.00 105.67 ? 1104 ARG A CA    1 
ATOM   3024 C  C     . ARG A 1 759  ? 161.891 183.346 161.336 1.00 105.51 ? 1104 ARG A C     1 
ATOM   3025 O  O     . ARG A 1 759  ? 162.499 182.285 161.154 1.00 106.06 ? 1104 ARG A O     1 
ATOM   3026 C  CB    . ARG A 1 759  ? 162.691 185.353 160.048 1.00 104.07 ? 1104 ARG A CB    1 
ATOM   3027 C  CG    . ARG A 1 759  ? 164.112 184.830 160.121 1.00 102.59 ? 1104 ARG A CG    1 
ATOM   3028 C  CD    . ARG A 1 759  ? 165.069 185.773 159.415 1.00 104.24 ? 1104 ARG A CD    1 
ATOM   3029 N  NE    . ARG A 1 759  ? 164.573 186.160 158.100 1.00 107.70 ? 1104 ARG A NE    1 
ATOM   3030 C  CZ    . ARG A 1 759  ? 164.885 187.293 157.485 1.00 107.99 ? 1104 ARG A CZ    1 
ATOM   3031 N  NH1   . ARG A 1 759  ? 165.696 188.179 158.037 1.00 107.16 ? 1104 ARG A NH1   1 
ATOM   3032 N  NH2   . ARG A 1 759  ? 164.369 187.542 156.284 1.00 105.30 ? 1104 ARG A NH2   1 
ATOM   3033 N  N     . SER A 1 760  ? 161.455 183.723 162.540 1.00 116.20 ? 1105 SER A N     1 
ATOM   3034 C  CA    . SER A 1 760  ? 161.662 182.956 163.765 1.00 119.89 ? 1105 SER A CA    1 
ATOM   3035 C  C     . SER A 1 760  ? 163.148 182.732 164.021 1.00 124.02 ? 1105 SER A C     1 
ATOM   3036 O  O     . SER A 1 760  ? 163.634 181.600 163.899 1.00 121.84 ? 1105 SER A O     1 
ATOM   3037 C  CB    . SER A 1 760  ? 160.925 181.617 163.698 1.00 119.34 ? 1105 SER A CB    1 
ATOM   3038 O  OG    . SER A 1 760  ? 161.294 180.777 164.778 1.00 120.19 ? 1105 SER A OG    1 
ATOM   3039 N  N     . PRO A 1 761  ? 163.907 183.781 164.379 1.00 131.50 ? 1106 PRO A N     1 
ATOM   3040 C  CA    . PRO A 1 761  ? 165.345 183.656 164.622 1.00 127.62 ? 1106 PRO A CA    1 
ATOM   3041 C  C     . PRO A 1 761  ? 165.665 183.269 166.063 1.00 126.37 ? 1106 PRO A C     1 
ATOM   3042 O  O     . PRO A 1 761  ? 166.116 184.126 166.823 1.00 125.37 ? 1106 PRO A O     1 
ATOM   3043 C  CB    . PRO A 1 761  ? 165.872 185.058 164.306 1.00 126.49 ? 1106 PRO A CB    1 
ATOM   3044 C  CG    . PRO A 1 761  ? 164.684 185.982 164.504 1.00 126.58 ? 1106 PRO A CG    1 
ATOM   3045 C  CD    . PRO A 1 761  ? 163.432 185.149 164.641 1.00 127.46 ? 1106 PRO A CD    1 
ATOM   3046 N  N     . LYS A 1 790  ? 175.306 154.556 162.041 1.00 85.70  ? 1135 LYS A N     1 
ATOM   3047 C  CA    . LYS A 1 790  ? 174.938 154.200 163.406 1.00 89.20  ? 1135 LYS A CA    1 
ATOM   3048 C  C     . LYS A 1 790  ? 174.539 152.733 163.503 1.00 89.41  ? 1135 LYS A C     1 
ATOM   3049 O  O     . LYS A 1 790  ? 175.362 151.876 163.819 1.00 85.75  ? 1135 LYS A O     1 
ATOM   3050 C  CB    . LYS A 1 790  ? 173.796 155.088 163.902 1.00 87.96  ? 1135 LYS A CB    1 
ATOM   3051 C  CG    . LYS A 1 790  ? 174.228 156.491 164.290 1.00 87.16  ? 1135 LYS A CG    1 
ATOM   3052 C  CD    . LYS A 1 790  ? 175.168 156.462 165.483 1.00 85.41  ? 1135 LYS A CD    1 
ATOM   3053 C  CE    . LYS A 1 790  ? 174.488 155.868 166.704 1.00 85.79  ? 1135 LYS A CE    1 
ATOM   3054 N  NZ    . LYS A 1 790  ? 175.389 155.845 167.888 1.00 88.31  ? 1135 LYS A NZ    1 
ATOM   3055 N  N     . LEU A 1 791  ? 173.271 152.455 163.233 1.00 88.69  ? 1136 LEU A N     1 
ATOM   3056 C  CA    . LEU A 1 791  ? 172.783 151.085 163.293 1.00 87.68  ? 1136 LEU A CA    1 
ATOM   3057 C  C     . LEU A 1 791  ? 173.392 150.269 162.160 1.00 87.00  ? 1136 LEU A C     1 
ATOM   3058 O  O     . LEU A 1 791  ? 173.307 150.677 160.996 1.00 87.29  ? 1136 LEU A O     1 
ATOM   3059 C  CB    . LEU A 1 791  ? 171.261 151.057 163.202 1.00 86.90  ? 1136 LEU A CB    1 
ATOM   3060 C  CG    . LEU A 1 791  ? 170.511 151.516 164.451 1.00 89.91  ? 1136 LEU A CG    1 
ATOM   3061 C  CD1   . LEU A 1 791  ? 169.013 151.505 164.207 1.00 87.88  ? 1136 LEU A CD1   1 
ATOM   3062 C  CD2   . LEU A 1 791  ? 170.871 150.640 165.638 1.00 88.98  ? 1136 LEU A CD2   1 
ATOM   3063 N  N     . PRO A 1 792  ? 174.022 149.132 162.451 1.00 80.32  ? 1137 PRO A N     1 
ATOM   3064 C  CA    . PRO A 1 792  ? 174.548 148.291 161.371 1.00 79.27  ? 1137 PRO A CA    1 
ATOM   3065 C  C     . PRO A 1 792  ? 173.422 147.790 160.481 1.00 78.88  ? 1137 PRO A C     1 
ATOM   3066 O  O     . PRO A 1 792  ? 172.351 147.409 160.957 1.00 79.39  ? 1137 PRO A O     1 
ATOM   3067 C  CB    . PRO A 1 792  ? 175.233 147.141 162.117 1.00 78.08  ? 1137 PRO A CB    1 
ATOM   3068 C  CG    . PRO A 1 792  ? 174.558 147.099 163.445 1.00 79.93  ? 1137 PRO A CG    1 
ATOM   3069 C  CD    . PRO A 1 792  ? 174.218 148.522 163.776 1.00 79.57  ? 1137 PRO A CD    1 
ATOM   3070 N  N     . LYS A 1 793  ? 173.675 147.792 159.178 1.00 64.53  ? 1138 LYS A N     1 
ATOM   3071 C  CA    . LYS A 1 793  ? 172.657 147.371 158.229 1.00 61.44  ? 1138 LYS A CA    1 
ATOM   3072 C  C     . LYS A 1 793  ? 172.440 145.867 158.312 1.00 62.44  ? 1138 LYS A C     1 
ATOM   3073 O  O     . LYS A 1 793  ? 173.382 145.097 158.516 1.00 62.87  ? 1138 LYS A O     1 
ATOM   3074 C  CB    . LYS A 1 793  ? 173.057 147.772 156.811 1.00 60.70  ? 1138 LYS A CB    1 
ATOM   3075 C  CG    . LYS A 1 793  ? 173.180 149.271 156.610 1.00 64.80  ? 1138 LYS A CG    1 
ATOM   3076 C  CD    . LYS A 1 793  ? 173.761 149.601 155.247 1.00 64.56  ? 1138 LYS A CD    1 
ATOM   3077 C  CE    . LYS A 1 793  ? 174.034 151.088 155.113 1.00 65.03  ? 1138 LYS A CE    1 
ATOM   3078 N  NZ    . LYS A 1 793  ? 174.774 151.622 156.290 1.00 66.32  ? 1138 LYS A NZ    1 
ATOM   3079 N  N     . LEU A 1 794  ? 171.187 145.450 158.161 1.00 48.13  ? 1139 LEU A N     1 
ATOM   3080 C  CA    . LEU A 1 794  ? 170.872 144.029 158.171 1.00 42.53  ? 1139 LEU A CA    1 
ATOM   3081 C  C     . LEU A 1 794  ? 171.424 143.361 156.921 1.00 50.14  ? 1139 LEU A C     1 
ATOM   3082 O  O     . LEU A 1 794  ? 171.179 143.820 155.802 1.00 54.62  ? 1139 LEU A O     1 
ATOM   3083 C  CB    . LEU A 1 794  ? 169.361 143.812 158.237 1.00 38.76  ? 1139 LEU A CB    1 
ATOM   3084 C  CG    . LEU A 1 794  ? 168.512 144.676 159.161 1.00 43.05  ? 1139 LEU A CG    1 
ATOM   3085 C  CD1   . LEU A 1 794  ? 167.044 144.448 158.859 1.00 36.66  ? 1139 LEU A CD1   1 
ATOM   3086 C  CD2   . LEU A 1 794  ? 168.820 144.357 160.607 1.00 49.42  ? 1139 LEU A CD2   1 
ATOM   3087 N  N     . ARG A 1 795  ? 172.161 142.271 157.108 1.00 50.85  ? 1140 ARG A N     1 
ATOM   3088 C  CA    . ARG A 1 795  ? 172.510 141.426 155.978 1.00 48.64  ? 1140 ARG A CA    1 
ATOM   3089 C  C     . ARG A 1 795  ? 171.234 140.848 155.387 1.00 44.34  ? 1140 ARG A C     1 
ATOM   3090 O  O     . ARG A 1 795  ? 170.401 140.289 156.107 1.00 53.27  ? 1140 ARG A O     1 
ATOM   3091 C  CB    . ARG A 1 795  ? 173.455 140.312 156.415 1.00 44.14  ? 1140 ARG A CB    1 
ATOM   3092 C  CG    . ARG A 1 795  ? 174.729 140.811 157.060 1.00 45.81  ? 1140 ARG A CG    1 
ATOM   3093 C  CD    . ARG A 1 795  ? 175.619 139.661 157.487 1.00 51.17  ? 1140 ARG A CD    1 
ATOM   3094 N  NE    . ARG A 1 795  ? 175.118 139.001 158.686 1.00 47.10  ? 1140 ARG A NE    1 
ATOM   3095 C  CZ    . ARG A 1 795  ? 175.301 139.454 159.918 1.00 50.52  ? 1140 ARG A CZ    1 
ATOM   3096 N  NH1   . ARG A 1 795  ? 175.965 140.574 160.151 1.00 53.09  ? 1140 ARG A NH1   1 
ATOM   3097 N  NH2   . ARG A 1 795  ? 174.805 138.767 160.942 1.00 50.37  ? 1140 ARG A NH2   1 
ATOM   3098 N  N     . THR A 1 796  ? 171.071 140.993 154.079 1.00 32.57  ? 1141 THR A N     1 
ATOM   3099 C  CA    . THR A 1 796  ? 169.811 140.693 153.424 1.00 31.67  ? 1141 THR A CA    1 
ATOM   3100 C  C     . THR A 1 796  ? 170.009 139.630 152.361 1.00 38.99  ? 1141 THR A C     1 
ATOM   3101 O  O     . THR A 1 796  ? 170.945 139.705 151.557 1.00 61.60  ? 1141 THR A O     1 
ATOM   3102 C  CB    . THR A 1 796  ? 169.211 141.950 152.787 1.00 40.23  ? 1141 THR A CB    1 
ATOM   3103 O  OG1   . THR A 1 796  ? 168.942 142.922 153.804 1.00 46.23  ? 1141 THR A OG1   1 
ATOM   3104 C  CG2   . THR A 1 796  ? 167.921 141.622 152.058 1.00 39.47  ? 1141 THR A CG2   1 
ATOM   3105 N  N     . LEU A 1 797  ? 169.129 138.637 152.383 1.00 31.44  ? 1142 LEU A N     1 
ATOM   3106 C  CA    . LEU A 1 797  ? 168.945 137.701 151.285 1.00 30.00  ? 1142 LEU A CA    1 
ATOM   3107 C  C     . LEU A 1 797  ? 167.637 138.061 150.595 1.00 33.38  ? 1142 LEU A C     1 
ATOM   3108 O  O     . LEU A 1 797  ? 166.597 138.205 151.255 1.00 47.99  ? 1142 LEU A O     1 
ATOM   3109 C  CB    . LEU A 1 797  ? 168.925 136.257 151.786 1.00 39.22  ? 1142 LEU A CB    1 
ATOM   3110 C  CG    . LEU A 1 797  ? 168.483 135.174 150.801 1.00 35.42  ? 1142 LEU A CG    1 
ATOM   3111 C  CD1   . LEU A 1 797  ? 169.479 135.055 149.673 1.00 31.58  ? 1142 LEU A CD1   1 
ATOM   3112 C  CD2   . LEU A 1 797  ? 168.344 133.846 151.512 1.00 39.01  ? 1142 LEU A CD2   1 
ATOM   3113 N  N     . ASP A 1 798  ? 167.694 138.229 149.281 1.00 34.46  ? 1143 ASP A N     1 
ATOM   3114 C  CA    . ASP A 1 798  ? 166.540 138.652 148.502 1.00 36.07  ? 1143 ASP A CA    1 
ATOM   3115 C  C     . ASP A 1 798  ? 166.255 137.531 147.511 1.00 37.94  ? 1143 ASP A C     1 
ATOM   3116 O  O     . ASP A 1 798  ? 167.066 137.256 146.623 1.00 42.68  ? 1143 ASP A O     1 
ATOM   3117 C  CB    . ASP A 1 798  ? 166.829 139.993 147.819 1.00 46.34  ? 1143 ASP A CB    1 
ATOM   3118 C  CG    . ASP A 1 798  ? 165.837 140.351 146.706 1.00 56.86  ? 1143 ASP A CG    1 
ATOM   3119 O  OD1   . ASP A 1 798  ? 165.194 139.477 146.093 1.00 60.60  ? 1143 ASP A OD1   1 
ATOM   3120 O  OD2   . ASP A 1 798  ? 165.700 141.565 146.440 1.00 54.50  ? 1143 ASP A OD2   1 
ATOM   3121 N  N     . VAL A 1 799  ? 165.100 136.895 147.662 1.00 43.59  ? 1144 VAL A N     1 
ATOM   3122 C  CA    . VAL A 1 799  ? 164.683 135.796 146.798 1.00 48.38  ? 1144 VAL A CA    1 
ATOM   3123 C  C     . VAL A 1 799  ? 163.699 136.335 145.771 1.00 45.99  ? 1144 VAL A C     1 
ATOM   3124 O  O     . VAL A 1 799  ? 162.832 137.151 146.105 1.00 52.54  ? 1144 VAL A O     1 
ATOM   3125 C  CB    . VAL A 1 799  ? 164.065 134.648 147.613 1.00 46.51  ? 1144 VAL A CB    1 
ATOM   3126 C  CG1   . VAL A 1 799  ? 164.043 133.378 146.794 1.00 43.64  ? 1144 VAL A CG1   1 
ATOM   3127 C  CG2   . VAL A 1 799  ? 164.847 134.431 148.889 1.00 41.42  ? 1144 VAL A CG2   1 
ATOM   3128 N  N     . PHE A 1 800  ? 163.836 135.884 144.523 1.00 42.68  ? 1145 PHE A N     1 
ATOM   3129 C  CA    . PHE A 1 800  ? 163.034 136.377 143.404 1.00 47.72  ? 1145 PHE A CA    1 
ATOM   3130 C  C     . PHE A 1 800  ? 163.192 137.890 143.256 1.00 57.68  ? 1145 PHE A C     1 
ATOM   3131 O  O     . PHE A 1 800  ? 162.251 138.663 143.442 1.00 67.12  ? 1145 PHE A O     1 
ATOM   3132 C  CB    . PHE A 1 800  ? 161.557 136.003 143.556 1.00 54.27  ? 1145 PHE A CB    1 
ATOM   3133 C  CG    . PHE A 1 800  ? 161.322 134.668 144.188 1.00 50.61  ? 1145 PHE A CG    1 
ATOM   3134 C  CD1   . PHE A 1 800  ? 161.594 133.503 143.501 1.00 56.41  ? 1145 PHE A CD1   1 
ATOM   3135 C  CD2   . PHE A 1 800  ? 160.801 134.580 145.465 1.00 53.79  ? 1145 PHE A CD2   1 
ATOM   3136 C  CE1   . PHE A 1 800  ? 161.364 132.274 144.081 1.00 58.22  ? 1145 PHE A CE1   1 
ATOM   3137 C  CE2   . PHE A 1 800  ? 160.569 133.357 146.049 1.00 61.10  ? 1145 PHE A CE2   1 
ATOM   3138 C  CZ    . PHE A 1 800  ? 160.852 132.201 145.356 1.00 60.22  ? 1145 PHE A CZ    1 
ATOM   3139 N  N     . SER A 1 801  ? 164.410 138.307 142.915 1.00 55.80  ? 1146 SER A N     1 
ATOM   3140 C  CA    . SER A 1 801  ? 164.723 139.731 142.918 1.00 55.73  ? 1146 SER A CA    1 
ATOM   3141 C  C     . SER A 1 801  ? 164.329 140.393 141.605 1.00 58.55  ? 1146 SER A C     1 
ATOM   3142 O  O     . SER A 1 801  ? 163.470 141.282 141.574 1.00 59.64  ? 1146 SER A O     1 
ATOM   3143 C  CB    . SER A 1 801  ? 166.213 139.931 143.176 1.00 52.58  ? 1146 SER A CB    1 
ATOM   3144 O  OG    . SER A 1 801  ? 166.894 140.121 141.952 1.00 51.54  ? 1146 SER A OG    1 
ATOM   3145 N  N     . GLY A 1 802  ? 164.936 139.963 140.504 1.00 52.36  ? 1147 GLY A N     1 
ATOM   3146 C  CA    . GLY A 1 802  ? 164.815 140.708 139.267 1.00 49.68  ? 1147 GLY A CA    1 
ATOM   3147 C  C     . GLY A 1 802  ? 165.864 141.805 139.198 1.00 49.16  ? 1147 GLY A C     1 
ATOM   3148 O  O     . GLY A 1 802  ? 166.996 141.645 139.655 1.00 54.33  ? 1147 GLY A O     1 
ATOM   3149 N  N     . CYS A 1 803  ? 165.471 142.946 138.633 1.00 48.72  ? 1148 CYS A N     1 
ATOM   3150 C  CA    . CYS A 1 803  ? 166.385 144.080 138.579 1.00 46.90  ? 1148 CYS A CA    1 
ATOM   3151 C  C     . CYS A 1 803  ? 166.693 144.628 139.964 1.00 57.18  ? 1148 CYS A C     1 
ATOM   3152 O  O     . CYS A 1 803  ? 167.654 145.389 140.119 1.00 58.79  ? 1148 CYS A O     1 
ATOM   3153 C  CB    . CYS A 1 803  ? 165.808 145.184 137.697 1.00 51.48  ? 1148 CYS A CB    1 
ATOM   3154 S  SG    . CYS A 1 803  ? 164.163 145.732 138.184 1.00 56.47  ? 1148 CYS A SG    1 
ATOM   3155 N  N     . GLY A 1 804  ? 165.899 144.267 140.970 1.00 60.05  ? 1149 GLY A N     1 
ATOM   3156 C  CA    . GLY A 1 804  ? 166.179 144.656 142.336 1.00 52.84  ? 1149 GLY A CA    1 
ATOM   3157 C  C     . GLY A 1 804  ? 165.494 145.932 142.771 1.00 49.07  ? 1149 GLY A C     1 
ATOM   3158 O  O     . GLY A 1 804  ? 166.148 146.842 143.286 1.00 57.38  ? 1149 GLY A O     1 
ATOM   3159 N  N     . GLY A 1 805  ? 164.182 146.026 142.557 1.00 27.57  ? 1150 GLY A N     1 
ATOM   3160 C  CA    . GLY A 1 805  ? 163.459 147.196 143.027 1.00 40.20  ? 1150 GLY A CA    1 
ATOM   3161 C  C     . GLY A 1 805  ? 163.398 147.267 144.541 1.00 45.13  ? 1150 GLY A C     1 
ATOM   3162 O  O     . GLY A 1 805  ? 163.697 148.304 145.142 1.00 53.07  ? 1150 GLY A O     1 
ATOM   3163 N  N     . LEU A 1 806  ? 163.017 146.159 145.178 1.00 42.26  ? 1151 LEU A N     1 
ATOM   3164 C  CA    . LEU A 1 806  ? 162.930 146.125 146.634 1.00 36.75  ? 1151 LEU A CA    1 
ATOM   3165 C  C     . LEU A 1 806  ? 164.295 146.346 147.269 1.00 43.79  ? 1151 LEU A C     1 
ATOM   3166 O  O     . LEU A 1 806  ? 164.421 147.081 148.257 1.00 49.77  ? 1151 LEU A O     1 
ATOM   3167 C  CB    . LEU A 1 806  ? 162.340 144.789 147.079 1.00 35.62  ? 1151 LEU A CB    1 
ATOM   3168 C  CG    . LEU A 1 806  ? 161.559 144.750 148.388 1.00 43.44  ? 1151 LEU A CG    1 
ATOM   3169 C  CD1   . LEU A 1 806  ? 160.239 145.474 148.227 1.00 43.88  ? 1151 LEU A CD1   1 
ATOM   3170 C  CD2   . LEU A 1 806  ? 161.332 143.313 148.805 1.00 47.28  ? 1151 LEU A CD2   1 
ATOM   3171 N  N     . SER A 1 807  ? 165.329 145.714 146.714 1.00 48.80  ? 1152 SER A N     1 
ATOM   3172 C  CA    . SER A 1 807  ? 166.675 145.883 147.243 1.00 43.82  ? 1152 SER A CA    1 
ATOM   3173 C  C     . SER A 1 807  ? 167.136 147.329 147.125 1.00 47.86  ? 1152 SER A C     1 
ATOM   3174 O  O     . SER A 1 807  ? 167.740 147.867 148.055 1.00 60.39  ? 1152 SER A O     1 
ATOM   3175 C  CB    . SER A 1 807  ? 167.641 144.949 146.520 1.00 53.42  ? 1152 SER A CB    1 
ATOM   3176 O  OG    . SER A 1 807  ? 167.039 143.690 146.278 1.00 59.62  ? 1152 SER A OG    1 
ATOM   3177 N  N     . GLU A 1 808  ? 166.861 147.976 145.990 1.00 46.48  ? 1153 GLU A N     1 
ATOM   3178 C  CA    . GLU A 1 808  ? 167.242 149.376 145.831 1.00 45.07  ? 1153 GLU A CA    1 
ATOM   3179 C  C     . GLU A 1 808  ? 166.488 150.274 146.803 1.00 49.22  ? 1153 GLU A C     1 
ATOM   3180 O  O     . GLU A 1 808  ? 167.072 151.191 147.396 1.00 55.86  ? 1153 GLU A O     1 
ATOM   3181 C  CB    . GLU A 1 808  ? 167.001 149.829 144.393 1.00 46.51  ? 1153 GLU A CB    1 
ATOM   3182 C  CG    . GLU A 1 808  ? 167.121 151.326 144.196 1.00 46.95  ? 1153 GLU A CG    1 
ATOM   3183 C  CD    . GLU A 1 808  ? 168.559 151.796 144.194 1.00 57.84  ? 1153 GLU A CD    1 
ATOM   3184 O  OE1   . GLU A 1 808  ? 169.461 150.946 144.043 1.00 59.81  ? 1153 GLU A OE1   1 
ATOM   3185 O  OE2   . GLU A 1 808  ? 168.790 153.013 144.346 1.00 57.30  ? 1153 GLU A OE2   1 
ATOM   3186 N  N     . GLY A 1 809  ? 165.188 150.030 146.975 1.00 43.80  ? 1154 GLY A N     1 
ATOM   3187 C  CA    . GLY A 1 809  ? 164.424 150.826 147.922 1.00 37.86  ? 1154 GLY A CA    1 
ATOM   3188 C  C     . GLY A 1 809  ? 164.953 150.700 149.336 1.00 44.37  ? 1154 GLY A C     1 
ATOM   3189 O  O     . GLY A 1 809  ? 165.110 151.695 150.047 1.00 56.70  ? 1154 GLY A O     1 
ATOM   3190 N  N     . PHE A 1 810  ? 165.252 149.471 149.759 1.00 36.99  ? 1155 PHE A N     1 
ATOM   3191 C  CA    . PHE A 1 810  ? 165.796 149.273 151.097 1.00 38.69  ? 1155 PHE A CA    1 
ATOM   3192 C  C     . PHE A 1 810  ? 167.187 149.881 151.222 1.00 40.92  ? 1155 PHE A C     1 
ATOM   3193 O  O     . PHE A 1 810  ? 167.530 150.445 152.266 1.00 45.79  ? 1155 PHE A O     1 
ATOM   3194 C  CB    . PHE A 1 810  ? 165.823 147.786 151.436 1.00 47.85  ? 1155 PHE A CB    1 
ATOM   3195 C  CG    . PHE A 1 810  ? 164.484 147.231 151.818 1.00 48.45  ? 1155 PHE A CG    1 
ATOM   3196 C  CD1   . PHE A 1 810  ? 163.340 147.996 151.695 1.00 41.10  ? 1155 PHE A CD1   1 
ATOM   3197 C  CD2   . PHE A 1 810  ? 164.366 145.939 152.285 1.00 43.49  ? 1155 PHE A CD2   1 
ATOM   3198 C  CE1   . PHE A 1 810  ? 162.109 147.484 152.041 1.00 38.38  ? 1155 PHE A CE1   1 
ATOM   3199 C  CE2   . PHE A 1 810  ? 163.138 145.429 152.626 1.00 37.68  ? 1155 PHE A CE2   1 
ATOM   3200 C  CZ    . PHE A 1 810  ? 162.010 146.200 152.507 1.00 38.56  ? 1155 PHE A CZ    1 
ATOM   3201 N  N     . HIS A 1 811  ? 167.999 149.780 150.168 1.00 49.15  ? 1156 HIS A N     1 
ATOM   3202 C  CA    . HIS A 1 811  ? 169.339 150.354 150.201 1.00 41.00  ? 1156 HIS A CA    1 
ATOM   3203 C  C     . HIS A 1 811  ? 169.283 151.860 150.389 1.00 53.35  ? 1156 HIS A C     1 
ATOM   3204 O  O     . HIS A 1 811  ? 170.056 152.423 151.172 1.00 61.64  ? 1156 HIS A O     1 
ATOM   3205 C  CB    . HIS A 1 811  ? 170.090 150.011 148.916 1.00 42.31  ? 1156 HIS A CB    1 
ATOM   3206 C  CG    . HIS A 1 811  ? 170.878 148.742 148.992 1.00 60.50  ? 1156 HIS A CG    1 
ATOM   3207 N  ND1   . HIS A 1 811  ? 172.254 148.716 148.922 1.00 67.54  ? 1156 HIS A ND1   1 
ATOM   3208 C  CD2   . HIS A 1 811  ? 170.484 147.453 149.119 1.00 60.51  ? 1156 HIS A CD2   1 
ATOM   3209 C  CE1   . HIS A 1 811  ? 172.674 147.467 149.009 1.00 58.79  ? 1156 HIS A CE1   1 
ATOM   3210 N  NE2   . HIS A 1 811  ? 171.620 146.681 149.129 1.00 57.65  ? 1156 HIS A NE2   1 
ATOM   3211 N  N     . GLN A 1 812  ? 168.377 152.533 149.679 1.00 53.40  ? 1157 GLN A N     1 
ATOM   3212 C  CA    . GLN A 1 812  ? 168.246 153.973 149.860 1.00 46.08  ? 1157 GLN A CA    1 
ATOM   3213 C  C     . GLN A 1 812  ? 167.452 154.339 151.106 1.00 45.89  ? 1157 GLN A C     1 
ATOM   3214 O  O     . GLN A 1 812  ? 167.448 155.511 151.493 1.00 50.87  ? 1157 GLN A O     1 
ATOM   3215 C  CB    . GLN A 1 812  ? 167.617 154.622 148.623 1.00 44.39  ? 1157 GLN A CB    1 
ATOM   3216 C  CG    . GLN A 1 812  ? 166.195 154.205 148.315 1.00 43.45  ? 1157 GLN A CG    1 
ATOM   3217 C  CD    . GLN A 1 812  ? 165.685 154.837 147.037 1.00 45.12  ? 1157 GLN A CD    1 
ATOM   3218 O  OE1   . GLN A 1 812  ? 166.453 155.095 146.113 1.00 43.29  ? 1157 GLN A OE1   1 
ATOM   3219 N  NE2   . GLN A 1 812  ? 164.385 155.095 146.979 1.00 43.50  ? 1157 GLN A NE2   1 
ATOM   3220 N  N     . ALA A 1 813  ? 166.783 153.374 151.739 1.00 44.77  ? 1158 ALA A N     1 
ATOM   3221 C  CA    . ALA A 1 813  ? 166.197 153.611 153.051 1.00 40.41  ? 1158 ALA A CA    1 
ATOM   3222 C  C     . ALA A 1 813  ? 167.236 153.589 154.161 1.00 39.37  ? 1158 ALA A C     1 
ATOM   3223 O  O     . ALA A 1 813  ? 166.977 154.123 155.243 1.00 48.99  ? 1158 ALA A O     1 
ATOM   3224 C  CB    . ALA A 1 813  ? 165.113 152.575 153.347 1.00 43.18  ? 1158 ALA A CB    1 
ATOM   3225 N  N     . GLY A 1 814  ? 168.396 152.984 153.920 1.00 38.73  ? 1159 GLY A N     1 
ATOM   3226 C  CA    . GLY A 1 814  ? 169.471 152.985 154.890 1.00 40.12  ? 1159 GLY A CA    1 
ATOM   3227 C  C     . GLY A 1 814  ? 169.401 151.915 155.952 1.00 45.88  ? 1159 GLY A C     1 
ATOM   3228 O  O     . GLY A 1 814  ? 170.005 152.086 157.016 1.00 52.13  ? 1159 GLY A O     1 
ATOM   3229 N  N     . ILE A 1 815  ? 168.688 150.818 155.709 1.00 52.10  ? 1160 ILE A N     1 
ATOM   3230 C  CA    . ILE A 1 815  ? 168.511 149.770 156.700 1.00 46.07  ? 1160 ILE A CA    1 
ATOM   3231 C  C     . ILE A 1 815  ? 169.172 148.465 156.275 1.00 46.59  ? 1160 ILE A C     1 
ATOM   3232 O  O     . ILE A 1 815  ? 169.720 147.749 157.114 1.00 60.73  ? 1160 ILE A O     1 
ATOM   3233 C  CB    . ILE A 1 815  ? 167.015 149.552 157.014 1.00 46.41  ? 1160 ILE A CB    1 
ATOM   3234 C  CG1   . ILE A 1 815  ? 166.299 148.855 155.860 1.00 46.51  ? 1160 ILE A CG1   1 
ATOM   3235 C  CG2   . ILE A 1 815  ? 166.350 150.870 157.263 1.00 54.87  ? 1160 ILE A CG2   1 
ATOM   3236 C  CD1   . ILE A 1 815  ? 165.062 148.117 156.279 1.00 48.94  ? 1160 ILE A CD1   1 
ATOM   3237 N  N     . SER A 1 816  ? 169.135 148.135 154.991 1.00 44.31  ? 1161 SER A N     1 
ATOM   3238 C  CA    . SER A 1 816  ? 169.497 146.806 154.529 1.00 45.32  ? 1161 SER A CA    1 
ATOM   3239 C  C     . SER A 1 816  ? 170.836 146.824 153.808 1.00 47.29  ? 1161 SER A C     1 
ATOM   3240 O  O     . SER A 1 816  ? 171.415 147.876 153.530 1.00 58.81  ? 1161 SER A O     1 
ATOM   3241 C  CB    . SER A 1 816  ? 168.413 146.240 153.609 1.00 48.16  ? 1161 SER A CB    1 
ATOM   3242 O  OG    . SER A 1 816  ? 168.981 145.369 152.650 1.00 47.39  ? 1161 SER A OG    1 
ATOM   3243 N  N     . ASP A 1 817  ? 171.325 145.620 153.518 1.00 46.94  ? 1162 ASP A N     1 
ATOM   3244 C  CA    . ASP A 1 817  ? 172.525 145.438 152.705 1.00 51.65  ? 1162 ASP A CA    1 
ATOM   3245 C  C     . ASP A 1 817  ? 172.391 144.070 152.043 1.00 58.71  ? 1162 ASP A C     1 
ATOM   3246 O  O     . ASP A 1 817  ? 172.583 143.043 152.698 1.00 60.22  ? 1162 ASP A O     1 
ATOM   3247 C  CB    . ASP A 1 817  ? 173.785 145.538 153.551 1.00 51.67  ? 1162 ASP A CB    1 
ATOM   3248 C  CG    . ASP A 1 817  ? 175.043 145.538 152.718 1.00 61.85  ? 1162 ASP A CG    1 
ATOM   3249 O  OD1   . ASP A 1 817  ? 174.940 145.696 151.484 1.00 61.15  ? 1162 ASP A OD1   1 
ATOM   3250 O  OD2   . ASP A 1 817  ? 176.136 145.377 153.298 1.00 64.03  ? 1162 ASP A OD2   1 
ATOM   3251 N  N     . THR A 1 818  ? 172.035 144.066 150.762 1.00 54.81  ? 1163 THR A N     1 
ATOM   3252 C  CA    . THR A 1 818  ? 171.726 142.833 150.041 1.00 45.32  ? 1163 THR A CA    1 
ATOM   3253 C  C     . THR A 1 818  ? 173.023 142.097 149.744 1.00 40.57  ? 1163 THR A C     1 
ATOM   3254 O  O     . THR A 1 818  ? 173.724 142.418 148.784 1.00 44.60  ? 1163 THR A O     1 
ATOM   3255 C  CB    . THR A 1 818  ? 170.968 143.139 148.756 1.00 40.21  ? 1163 THR A CB    1 
ATOM   3256 O  OG1   . THR A 1 818  ? 170.073 144.234 148.979 1.00 46.99  ? 1163 THR A OG1   1 
ATOM   3257 C  CG2   . THR A 1 818  ? 170.173 141.931 148.307 1.00 40.34  ? 1163 THR A CG2   1 
ATOM   3258 N  N     . LEU A 1 819  ? 173.346 141.097 150.559 1.00 44.10  ? 1164 LEU A N     1 
ATOM   3259 C  CA    . LEU A 1 819  ? 174.598 140.378 150.373 1.00 45.93  ? 1164 LEU A CA    1 
ATOM   3260 C  C     . LEU A 1 819  ? 174.451 139.129 149.519 1.00 54.33  ? 1164 LEU A C     1 
ATOM   3261 O  O     . LEU A 1 819  ? 175.467 138.531 149.153 1.00 67.61  ? 1164 LEU A O     1 
ATOM   3262 C  CB    . LEU A 1 819  ? 175.203 139.995 151.725 1.00 44.22  ? 1164 LEU A CB    1 
ATOM   3263 C  CG    . LEU A 1 819  ? 175.827 141.143 152.514 1.00 54.04  ? 1164 LEU A CG    1 
ATOM   3264 C  CD1   . LEU A 1 819  ? 176.586 140.611 153.714 1.00 56.21  ? 1164 LEU A CD1   1 
ATOM   3265 C  CD2   . LEU A 1 819  ? 176.736 141.966 151.621 1.00 54.03  ? 1164 LEU A CD2   1 
ATOM   3266 N  N     . TRP A 1 820  ? 173.227 138.725 149.193 1.00 47.90  ? 1165 TRP A N     1 
ATOM   3267 C  CA    . TRP A 1 820  ? 172.993 137.555 148.361 1.00 42.91  ? 1165 TRP A CA    1 
ATOM   3268 C  C     . TRP A 1 820  ? 171.722 137.779 147.560 1.00 45.80  ? 1165 TRP A C     1 
ATOM   3269 O  O     . TRP A 1 820  ? 170.864 138.580 147.934 1.00 55.13  ? 1165 TRP A O     1 
ATOM   3270 C  CB    . TRP A 1 820  ? 172.878 136.275 149.195 1.00 40.25  ? 1165 TRP A CB    1 
ATOM   3271 C  CG    . TRP A 1 820  ? 174.083 135.983 150.027 1.00 46.88  ? 1165 TRP A CG    1 
ATOM   3272 C  CD1   . TRP A 1 820  ? 175.300 135.568 149.583 1.00 50.80  ? 1165 TRP A CD1   1 
ATOM   3273 C  CD2   . TRP A 1 820  ? 174.187 136.080 151.451 1.00 42.19  ? 1165 TRP A CD2   1 
ATOM   3274 N  NE1   . TRP A 1 820  ? 176.159 135.403 150.640 1.00 49.49  ? 1165 TRP A NE1   1 
ATOM   3275 C  CE2   . TRP A 1 820  ? 175.498 135.712 151.798 1.00 43.02  ? 1165 TRP A CE2   1 
ATOM   3276 C  CE3   . TRP A 1 820  ? 173.299 136.445 152.465 1.00 46.11  ? 1165 TRP A CE3   1 
ATOM   3277 C  CZ2   . TRP A 1 820  ? 175.943 135.697 153.113 1.00 46.65  ? 1165 TRP A CZ2   1 
ATOM   3278 C  CZ3   . TRP A 1 820  ? 173.743 136.430 153.767 1.00 44.87  ? 1165 TRP A CZ3   1 
ATOM   3279 C  CH2   . TRP A 1 820  ? 175.052 136.058 154.082 1.00 44.81  ? 1165 TRP A CH2   1 
ATOM   3280 N  N     . ALA A 1 821  ? 171.608 137.064 146.446 1.00 38.78  ? 1166 ALA A N     1 
ATOM   3281 C  CA    . ALA A 1 821  ? 170.418 137.180 145.620 1.00 34.57  ? 1166 ALA A CA    1 
ATOM   3282 C  C     . ALA A 1 821  ? 170.134 135.839 144.967 1.00 44.60  ? 1166 ALA A C     1 
ATOM   3283 O  O     . ALA A 1 821  ? 171.033 135.013 144.798 1.00 58.09  ? 1166 ALA A O     1 
ATOM   3284 C  CB    . ALA A 1 821  ? 170.575 138.272 144.560 1.00 45.97  ? 1166 ALA A CB    1 
ATOM   3285 N  N     . ILE A 1 822  ? 168.872 135.633 144.608 1.00 46.97  ? 1167 ILE A N     1 
ATOM   3286 C  CA    . ILE A 1 822  ? 168.415 134.412 143.957 1.00 54.07  ? 1167 ILE A CA    1 
ATOM   3287 C  C     . ILE A 1 822  ? 167.576 134.819 142.754 1.00 58.50  ? 1167 ILE A C     1 
ATOM   3288 O  O     . ILE A 1 822  ? 166.490 135.388 142.914 1.00 63.73  ? 1167 ILE A O     1 
ATOM   3289 C  CB    . ILE A 1 822  ? 167.615 133.517 144.923 1.00 53.55  ? 1167 ILE A CB    1 
ATOM   3290 C  CG1   . ILE A 1 822  ? 168.551 132.581 145.679 1.00 46.75  ? 1167 ILE A CG1   1 
ATOM   3291 C  CG2   . ILE A 1 822  ? 166.599 132.672 144.175 1.00 53.01  ? 1167 ILE A CG2   1 
ATOM   3292 C  CD1   . ILE A 1 822  ? 169.017 131.410 144.855 1.00 52.27  ? 1167 ILE A CD1   1 
ATOM   3293 N  N     . GLU A 1 823  ? 168.104 134.581 141.555 1.00 69.74  ? 1168 GLU A N     1 
ATOM   3294 C  CA    . GLU A 1 823  ? 167.382 134.916 140.329 1.00 64.44  ? 1168 GLU A CA    1 
ATOM   3295 C  C     . GLU A 1 823  ? 168.067 134.182 139.184 1.00 69.60  ? 1168 GLU A C     1 
ATOM   3296 O  O     . GLU A 1 823  ? 169.245 134.436 138.915 1.00 83.19  ? 1168 GLU A O     1 
ATOM   3297 C  CB    . GLU A 1 823  ? 167.380 136.425 140.101 1.00 60.25  ? 1168 GLU A CB    1 
ATOM   3298 C  CG    . GLU A 1 823  ? 166.744 136.929 138.800 1.00 67.89  ? 1168 GLU A CG    1 
ATOM   3299 C  CD    . GLU A 1 823  ? 165.256 136.619 138.666 1.00 74.61  ? 1168 GLU A CD    1 
ATOM   3300 O  OE1   . GLU A 1 823  ? 164.844 135.453 138.837 1.00 81.88  ? 1168 GLU A OE1   1 
ATOM   3301 O  OE2   . GLU A 1 823  ? 164.488 137.564 138.394 1.00 69.88  ? 1168 GLU A OE2   1 
ATOM   3302 N  N     . MET A 1 824  ? 167.344 133.283 138.511 1.00 65.78  ? 1169 MET A N     1 
ATOM   3303 C  CA    . MET A 1 824  ? 167.992 132.485 137.475 1.00 76.89  ? 1169 MET A CA    1 
ATOM   3304 C  C     . MET A 1 824  ? 168.002 133.203 136.133 1.00 82.13  ? 1169 MET A C     1 
ATOM   3305 O  O     . MET A 1 824  ? 168.976 133.096 135.380 1.00 86.28  ? 1169 MET A O     1 
ATOM   3306 C  CB    . MET A 1 824  ? 167.316 131.124 137.326 1.00 78.54  ? 1169 MET A CB    1 
ATOM   3307 C  CG    . MET A 1 824  ? 165.811 131.133 137.375 1.00 77.17  ? 1169 MET A CG    1 
ATOM   3308 S  SD    . MET A 1 824  ? 165.170 129.461 137.578 1.00 94.28  ? 1169 MET A SD    1 
ATOM   3309 C  CE    . MET A 1 824  ? 164.583 129.118 135.921 1.00 77.76  ? 1169 MET A CE    1 
ATOM   3310 N  N     . TRP A 1 825  ? 166.923 133.905 135.803 1.00 69.02  ? 1170 TRP A N     1 
ATOM   3311 C  CA    . TRP A 1 825  ? 166.833 134.589 134.520 1.00 64.08  ? 1170 TRP A CA    1 
ATOM   3312 C  C     . TRP A 1 825  ? 168.054 135.478 134.295 1.00 61.57  ? 1170 TRP A C     1 
ATOM   3313 O  O     . TRP A 1 825  ? 168.301 136.425 135.046 1.00 65.36  ? 1170 TRP A O     1 
ATOM   3314 C  CB    . TRP A 1 825  ? 165.545 135.405 134.462 1.00 62.25  ? 1170 TRP A CB    1 
ATOM   3315 C  CG    . TRP A 1 825  ? 165.111 135.759 133.079 1.00 69.52  ? 1170 TRP A CG    1 
ATOM   3316 C  CD1   . TRP A 1 825  ? 164.988 134.916 132.016 1.00 70.80  ? 1170 TRP A CD1   1 
ATOM   3317 C  CD2   . TRP A 1 825  ? 164.712 137.051 132.613 1.00 68.41  ? 1170 TRP A CD2   1 
ATOM   3318 N  NE1   . TRP A 1 825  ? 164.554 135.606 130.911 1.00 67.83  ? 1170 TRP A NE1   1 
ATOM   3319 C  CE2   . TRP A 1 825  ? 164.376 136.920 131.254 1.00 63.72  ? 1170 TRP A CE2   1 
ATOM   3320 C  CE3   . TRP A 1 825  ? 164.615 138.308 133.213 1.00 66.21  ? 1170 TRP A CE3   1 
ATOM   3321 C  CZ2   . TRP A 1 825  ? 163.949 137.996 130.488 1.00 65.09  ? 1170 TRP A CZ2   1 
ATOM   3322 C  CZ3   . TRP A 1 825  ? 164.192 139.372 132.454 1.00 64.08  ? 1170 TRP A CZ3   1 
ATOM   3323 C  CH2   . TRP A 1 825  ? 163.865 139.212 131.105 1.00 66.10  ? 1170 TRP A CH2   1 
ATOM   3324 N  N     . ASP A 1 826  ? 168.826 135.154 133.254 1.00 56.07  ? 1171 ASP A N     1 
ATOM   3325 C  CA    . ASP A 1 826  ? 170.144 135.734 133.004 1.00 63.21  ? 1171 ASP A CA    1 
ATOM   3326 C  C     . ASP A 1 826  ? 170.144 137.261 132.916 1.00 74.21  ? 1171 ASP A C     1 
ATOM   3327 O  O     . ASP A 1 826  ? 170.994 137.900 133.551 1.00 75.96  ? 1171 ASP A O     1 
ATOM   3328 C  CB    . ASP A 1 826  ? 170.747 135.139 131.728 1.00 67.65  ? 1171 ASP A CB    1 
ATOM   3329 C  CG    . ASP A 1 826  ? 170.795 133.625 131.759 1.00 76.61  ? 1171 ASP A CG    1 
ATOM   3330 O  OD1   . ASP A 1 826  ? 169.921 132.996 131.131 1.00 80.83  ? 1171 ASP A OD1   1 
ATOM   3331 O  OD2   . ASP A 1 826  ? 171.702 133.064 132.411 1.00 76.57  ? 1171 ASP A OD2   1 
ATOM   3332 N  N     . PRO A 1 827  ? 169.243 137.893 132.150 1.00 67.14  ? 1172 PRO A N     1 
ATOM   3333 C  CA    . PRO A 1 827  ? 169.267 139.363 132.107 1.00 56.88  ? 1172 PRO A CA    1 
ATOM   3334 C  C     . PRO A 1 827  ? 168.992 140.001 133.455 1.00 61.20  ? 1172 PRO A C     1 
ATOM   3335 O  O     . PRO A 1 827  ? 169.686 140.949 133.837 1.00 69.21  ? 1172 PRO A O     1 
ATOM   3336 C  CB    . PRO A 1 827  ? 168.177 139.702 131.082 1.00 55.29  ? 1172 PRO A CB    1 
ATOM   3337 C  CG    . PRO A 1 827  ? 167.993 138.459 130.295 1.00 64.65  ? 1172 PRO A CG    1 
ATOM   3338 C  CD    . PRO A 1 827  ? 168.197 137.355 131.264 1.00 66.74  ? 1172 PRO A CD    1 
ATOM   3339 N  N     . ALA A 1 828  ? 168.001 139.500 134.195 1.00 58.31  ? 1173 ALA A N     1 
ATOM   3340 C  CA    . ALA A 1 828  ? 167.716 140.055 135.513 1.00 54.42  ? 1173 ALA A CA    1 
ATOM   3341 C  C     . ALA A 1 828  ? 168.882 139.840 136.466 1.00 56.02  ? 1173 ALA A C     1 
ATOM   3342 O  O     . ALA A 1 828  ? 169.248 140.747 137.224 1.00 70.97  ? 1173 ALA A O     1 
ATOM   3343 C  CB    . ALA A 1 828  ? 166.439 139.440 136.080 1.00 52.90  ? 1173 ALA A CB    1 
ATOM   3344 N  N     . ALA A 1 829  ? 169.482 138.650 136.440 1.00 55.86  ? 1174 ALA A N     1 
ATOM   3345 C  CA    . ALA A 1 829  ? 170.614 138.377 137.316 1.00 58.68  ? 1174 ALA A CA    1 
ATOM   3346 C  C     . ALA A 1 829  ? 171.790 139.292 137.000 1.00 60.14  ? 1174 ALA A C     1 
ATOM   3347 O  O     . ALA A 1 829  ? 172.447 139.806 137.911 1.00 71.00  ? 1174 ALA A O     1 
ATOM   3348 C  CB    . ALA A 1 829  ? 171.025 136.911 137.201 1.00 60.56  ? 1174 ALA A CB    1 
ATOM   3349 N  N     . GLN A 1 830  ? 172.064 139.524 135.715 1.00 47.38  ? 1175 GLN A N     1 
ATOM   3350 C  CA    . GLN A 1 830  ? 173.186 140.389 135.370 1.00 51.81  ? 1175 GLN A CA    1 
ATOM   3351 C  C     . GLN A 1 830  ? 172.878 141.857 135.645 1.00 61.67  ? 1175 GLN A C     1 
ATOM   3352 O  O     . GLN A 1 830  ? 173.788 142.623 135.976 1.00 69.59  ? 1175 GLN A O     1 
ATOM   3353 C  CB    . GLN A 1 830  ? 173.594 140.169 133.915 1.00 52.94  ? 1175 GLN A CB    1 
ATOM   3354 C  CG    . GLN A 1 830  ? 174.462 138.932 133.732 1.00 56.76  ? 1175 GLN A CG    1 
ATOM   3355 C  CD    . GLN A 1 830  ? 174.171 138.182 132.452 1.00 64.85  ? 1175 GLN A CD    1 
ATOM   3356 O  OE1   . GLN A 1 830  ? 173.472 137.170 132.457 1.00 62.46  ? 1175 GLN A OE1   1 
ATOM   3357 N  NE2   . GLN A 1 830  ? 174.718 138.668 131.345 1.00 68.07  ? 1175 GLN A NE2   1 
ATOM   3358 N  N     . ALA A 1 831  ? 171.613 142.267 135.535 1.00 54.75  ? 1176 ALA A N     1 
ATOM   3359 C  CA    . ALA A 1 831  ? 171.242 143.614 135.960 1.00 50.37  ? 1176 ALA A CA    1 
ATOM   3360 C  C     . ALA A 1 831  ? 171.465 143.793 137.454 1.00 52.83  ? 1176 ALA A C     1 
ATOM   3361 O  O     . ALA A 1 831  ? 171.986 144.824 137.899 1.00 54.57  ? 1176 ALA A O     1 
ATOM   3362 C  CB    . ALA A 1 831  ? 169.786 143.897 135.601 1.00 49.06  ? 1176 ALA A CB    1 
ATOM   3363 N  N     . PHE A 1 832  ? 171.082 142.788 138.244 1.00 49.18  ? 1177 PHE A N     1 
ATOM   3364 C  CA    . PHE A 1 832  ? 171.346 142.821 139.677 1.00 42.04  ? 1177 PHE A CA    1 
ATOM   3365 C  C     . PHE A 1 832  ? 172.843 142.882 139.956 1.00 48.57  ? 1177 PHE A C     1 
ATOM   3366 O  O     . PHE A 1 832  ? 173.287 143.610 140.851 1.00 58.79  ? 1177 PHE A O     1 
ATOM   3367 C  CB    . PHE A 1 832  ? 170.719 141.595 140.340 1.00 40.72  ? 1177 PHE A CB    1 
ATOM   3368 C  CG    . PHE A 1 832  ? 170.522 141.731 141.819 1.00 51.44  ? 1177 PHE A CG    1 
ATOM   3369 C  CD1   . PHE A 1 832  ? 171.588 141.611 142.691 1.00 51.08  ? 1177 PHE A CD1   1 
ATOM   3370 C  CD2   . PHE A 1 832  ? 169.265 141.964 142.340 1.00 56.39  ? 1177 PHE A CD2   1 
ATOM   3371 C  CE1   . PHE A 1 832  ? 171.404 141.728 144.051 1.00 48.47  ? 1177 PHE A CE1   1 
ATOM   3372 C  CE2   . PHE A 1 832  ? 169.075 142.081 143.699 1.00 47.96  ? 1177 PHE A CE2   1 
ATOM   3373 C  CZ    . PHE A 1 832  ? 170.145 141.965 144.555 1.00 50.20  ? 1177 PHE A CZ    1 
ATOM   3374 N  N     . ARG A 1 833  ? 173.635 142.116 139.204 1.00 45.97  ? 1178 ARG A N     1 
ATOM   3375 C  CA    . ARG A 1 833  ? 175.083 142.143 139.380 1.00 45.21  ? 1178 ARG A CA    1 
ATOM   3376 C  C     . ARG A 1 833  ? 175.647 143.528 139.090 1.00 51.01  ? 1178 ARG A C     1 
ATOM   3377 O  O     . ARG A 1 833  ? 176.476 144.046 139.847 1.00 54.41  ? 1178 ARG A O     1 
ATOM   3378 C  CB    . ARG A 1 833  ? 175.737 141.102 138.472 1.00 50.26  ? 1178 ARG A CB    1 
ATOM   3379 C  CG    . ARG A 1 833  ? 175.990 139.761 139.126 1.00 50.99  ? 1178 ARG A CG    1 
ATOM   3380 C  CD    . ARG A 1 833  ? 175.714 138.630 138.152 1.00 48.03  ? 1178 ARG A CD    1 
ATOM   3381 N  NE    . ARG A 1 833  ? 176.261 137.360 138.610 1.00 56.63  ? 1178 ARG A NE    1 
ATOM   3382 C  CZ    . ARG A 1 833  ? 175.955 136.181 138.088 1.00 57.26  ? 1178 ARG A CZ    1 
ATOM   3383 N  NH1   . ARG A 1 833  ? 175.097 136.070 137.088 1.00 52.42  ? 1178 ARG A NH1   1 
ATOM   3384 N  NH2   . ARG A 1 833  ? 176.524 135.086 138.581 1.00 57.73  ? 1178 ARG A NH2   1 
ATOM   3385 N  N     . LEU A 1 834  ? 175.207 144.144 137.989 1.00 53.32  ? 1179 LEU A N     1 
ATOM   3386 C  CA    . LEU A 1 834  ? 175.700 145.470 137.629 1.00 48.98  ? 1179 LEU A CA    1 
ATOM   3387 C  C     . LEU A 1 834  ? 175.317 146.505 138.674 1.00 51.80  ? 1179 LEU A C     1 
ATOM   3388 O  O     . LEU A 1 834  ? 176.117 147.385 139.012 1.00 55.03  ? 1179 LEU A O     1 
ATOM   3389 C  CB    . LEU A 1 834  ? 175.156 145.885 136.263 1.00 48.79  ? 1179 LEU A CB    1 
ATOM   3390 C  CG    . LEU A 1 834  ? 175.673 145.172 135.019 1.00 55.74  ? 1179 LEU A CG    1 
ATOM   3391 C  CD1   . LEU A 1 834  ? 174.723 145.407 133.863 1.00 55.30  ? 1179 LEU A CD1   1 
ATOM   3392 C  CD2   . LEU A 1 834  ? 177.068 145.654 134.672 1.00 56.15  ? 1179 LEU A CD2   1 
ATOM   3393 N  N     . ASN A 1 835  ? 174.093 146.423 139.189 1.00 51.06  ? 1180 ASN A N     1 
ATOM   3394 C  CA    . ASN A 1 835  ? 173.593 147.455 140.087 1.00 47.95  ? 1180 ASN A CA    1 
ATOM   3395 C  C     . ASN A 1 835  ? 174.169 147.337 141.492 1.00 53.73  ? 1180 ASN A C     1 
ATOM   3396 O  O     . ASN A 1 835  ? 174.374 148.357 142.158 1.00 58.18  ? 1180 ASN A O     1 
ATOM   3397 C  CB    . ASN A 1 835  ? 172.072 147.389 140.128 1.00 50.16  ? 1180 ASN A CB    1 
ATOM   3398 C  CG    . ASN A 1 835  ? 171.447 147.910 138.863 1.00 57.25  ? 1180 ASN A CG    1 
ATOM   3399 O  OD1   . ASN A 1 835  ? 172.146 148.296 137.929 1.00 61.97  ? 1180 ASN A OD1   1 
ATOM   3400 N  ND2   . ASN A 1 835  ? 170.130 147.884 138.802 1.00 50.45  ? 1180 ASN A ND2   1 
ATOM   3401 N  N     . ASN A 1 836  ? 174.432 146.116 141.961 1.00 52.17  ? 1181 ASN A N     1 
ATOM   3402 C  CA    . ASN A 1 836  ? 174.986 145.869 143.292 1.00 46.72  ? 1181 ASN A CA    1 
ATOM   3403 C  C     . ASN A 1 836  ? 176.300 145.116 143.132 1.00 52.58  ? 1181 ASN A C     1 
ATOM   3404 O  O     . ASN A 1 836  ? 176.313 143.877 143.071 1.00 58.40  ? 1181 ASN A O     1 
ATOM   3405 C  CB    . ASN A 1 836  ? 174.003 145.088 144.159 1.00 42.05  ? 1181 ASN A CB    1 
ATOM   3406 C  CG    . ASN A 1 836  ? 172.619 145.695 144.159 1.00 48.19  ? 1181 ASN A CG    1 
ATOM   3407 O  OD1   . ASN A 1 836  ? 172.463 146.904 144.010 1.00 58.57  ? 1181 ASN A OD1   1 
ATOM   3408 N  ND2   . ASN A 1 836  ? 171.605 144.860 144.327 1.00 45.17  ? 1181 ASN A ND2   1 
ATOM   3409 N  N     . PRO A 1 837  ? 177.431 145.822 143.054 1.00 58.52  ? 1182 PRO A N     1 
ATOM   3410 C  CA    . PRO A 1 837  ? 178.707 145.139 142.789 1.00 55.88  ? 1182 PRO A CA    1 
ATOM   3411 C  C     . PRO A 1 837  ? 179.171 144.227 143.910 1.00 58.96  ? 1182 PRO A C     1 
ATOM   3412 O  O     . PRO A 1 837  ? 179.993 143.339 143.655 1.00 61.51  ? 1182 PRO A O     1 
ATOM   3413 C  CB    . PRO A 1 837  ? 179.694 146.298 142.579 1.00 56.89  ? 1182 PRO A CB    1 
ATOM   3414 C  CG    . PRO A 1 837  ? 178.848 147.523 142.396 1.00 58.87  ? 1182 PRO A CG    1 
ATOM   3415 C  CD    . PRO A 1 837  ? 177.599 147.278 143.172 1.00 61.97  ? 1182 PRO A CD    1 
ATOM   3416 N  N     . GLY A 1 838  ? 178.684 144.410 145.134 1.00 60.98  ? 1183 GLY A N     1 
ATOM   3417 C  CA    . GLY A 1 838  ? 179.220 143.676 146.263 1.00 64.40  ? 1183 GLY A CA    1 
ATOM   3418 C  C     . GLY A 1 838  ? 178.409 142.478 146.713 1.00 64.10  ? 1183 GLY A C     1 
ATOM   3419 O  O     . GLY A 1 838  ? 178.629 141.961 147.813 1.00 68.91  ? 1183 GLY A O     1 
ATOM   3420 N  N     . SER A 1 839  ? 177.479 142.018 145.884 1.00 47.67  ? 1184 SER A N     1 
ATOM   3421 C  CA    . SER A 1 839  ? 176.618 140.899 146.229 1.00 40.97  ? 1184 SER A CA    1 
ATOM   3422 C  C     . SER A 1 839  ? 176.884 139.727 145.298 1.00 49.73  ? 1184 SER A C     1 
ATOM   3423 O  O     . SER A 1 839  ? 177.277 139.907 144.142 1.00 58.52  ? 1184 SER A O     1 
ATOM   3424 C  CB    . SER A 1 839  ? 175.143 141.290 146.156 1.00 42.00  ? 1184 SER A CB    1 
ATOM   3425 O  OG    . SER A 1 839  ? 174.910 142.171 145.076 1.00 49.03  ? 1184 SER A OG    1 
ATOM   3426 N  N     . THR A 1 840  ? 176.664 138.521 145.813 1.00 43.82  ? 1185 THR A N     1 
ATOM   3427 C  CA    . THR A 1 840  ? 176.852 137.291 145.054 1.00 48.84  ? 1185 THR A CA    1 
ATOM   3428 C  C     . THR A 1 840  ? 175.484 136.787 144.610 1.00 41.17  ? 1185 THR A C     1 
ATOM   3429 O  O     . THR A 1 840  ? 174.650 136.420 145.443 1.00 40.51  ? 1185 THR A O     1 
ATOM   3430 C  CB    . THR A 1 840  ? 177.579 136.241 145.889 1.00 46.73  ? 1185 THR A CB    1 
ATOM   3431 O  OG1   . THR A 1 840  ? 176.638 135.565 146.732 1.00 49.01  ? 1185 THR A OG1   1 
ATOM   3432 C  CG2   . THR A 1 840  ? 178.637 136.897 146.754 1.00 43.97  ? 1185 THR A CG2   1 
ATOM   3433 N  N     . VAL A 1 841  ? 175.261 136.760 143.303 1.00 39.07  ? 1186 VAL A N     1 
ATOM   3434 C  CA    . VAL A 1 841  ? 173.979 136.357 142.741 1.00 44.23  ? 1186 VAL A CA    1 
ATOM   3435 C  C     . VAL A 1 841  ? 174.106 134.945 142.192 1.00 57.04  ? 1186 VAL A C     1 
ATOM   3436 O  O     . VAL A 1 841  ? 175.072 134.625 141.489 1.00 61.75  ? 1186 VAL A O     1 
ATOM   3437 C  CB    . VAL A 1 841  ? 173.532 137.336 141.645 1.00 43.37  ? 1186 VAL A CB    1 
ATOM   3438 C  CG1   . VAL A 1 841  ? 172.103 137.061 141.236 1.00 47.52  ? 1186 VAL A CG1   1 
ATOM   3439 C  CG2   . VAL A 1 841  ? 173.688 138.765 142.123 1.00 46.98  ? 1186 VAL A CG2   1 
ATOM   3440 N  N     . PHE A 1 842  ? 173.132 134.097 142.511 1.00 50.80  ? 1187 PHE A N     1 
ATOM   3441 C  CA    . PHE A 1 842  ? 173.135 132.699 142.089 1.00 46.15  ? 1187 PHE A CA    1 
ATOM   3442 C  C     . PHE A 1 842  ? 172.220 132.560 140.879 1.00 47.82  ? 1187 PHE A C     1 
ATOM   3443 O  O     . PHE A 1 842  ? 171.113 133.101 140.858 1.00 48.42  ? 1187 PHE A O     1 
ATOM   3444 C  CB    . PHE A 1 842  ? 172.691 131.787 143.227 1.00 48.94  ? 1187 PHE A CB    1 
ATOM   3445 C  CG    . PHE A 1 842  ? 173.562 131.870 144.448 1.00 50.57  ? 1187 PHE A CG    1 
ATOM   3446 C  CD1   . PHE A 1 842  ? 174.806 131.268 144.468 1.00 52.67  ? 1187 PHE A CD1   1 
ATOM   3447 C  CD2   . PHE A 1 842  ? 173.142 132.554 145.573 1.00 50.23  ? 1187 PHE A CD2   1 
ATOM   3448 C  CE1   . PHE A 1 842  ? 175.607 131.342 145.588 1.00 52.17  ? 1187 PHE A CE1   1 
ATOM   3449 C  CE2   . PHE A 1 842  ? 173.943 132.632 146.694 1.00 51.59  ? 1187 PHE A CE2   1 
ATOM   3450 C  CZ    . PHE A 1 842  ? 175.174 132.028 146.701 1.00 47.81  ? 1187 PHE A CZ    1 
ATOM   3451 N  N     . THR A 1 843  ? 172.681 131.808 139.880 1.00 78.93  ? 1188 THR A N     1 
ATOM   3452 C  CA    . THR A 1 843  ? 171.880 131.493 138.700 1.00 77.75  ? 1188 THR A CA    1 
ATOM   3453 C  C     . THR A 1 843  ? 171.565 129.999 138.733 1.00 79.77  ? 1188 THR A C     1 
ATOM   3454 O  O     . THR A 1 843  ? 172.256 129.157 138.154 1.00 83.15  ? 1188 THR A O     1 
ATOM   3455 C  CB    . THR A 1 843  ? 172.605 131.891 137.423 1.00 81.22  ? 1188 THR A CB    1 
ATOM   3456 O  OG1   . THR A 1 843  ? 173.013 133.262 137.508 1.00 78.62  ? 1188 THR A OG1   1 
ATOM   3457 C  CG2   . THR A 1 843  ? 171.701 131.706 136.214 1.00 75.97  ? 1188 THR A CG2   1 
ATOM   3458 N  N     . GLU A 1 844  ? 170.482 129.687 139.438 1.00 83.27  ? 1189 GLU A N     1 
ATOM   3459 C  CA    . GLU A 1 844  ? 170.042 128.322 139.665 1.00 85.55  ? 1189 GLU A CA    1 
ATOM   3460 C  C     . GLU A 1 844  ? 168.577 128.370 140.061 1.00 82.24  ? 1189 GLU A C     1 
ATOM   3461 O  O     . GLU A 1 844  ? 167.951 129.432 140.062 1.00 81.92  ? 1189 GLU A O     1 
ATOM   3462 C  CB    . GLU A 1 844  ? 170.879 127.643 140.758 1.00 82.63  ? 1189 GLU A CB    1 
ATOM   3463 C  CG    . GLU A 1 844  ? 171.444 126.283 140.378 1.00 84.14  ? 1189 GLU A CG    1 
ATOM   3464 C  CD    . GLU A 1 844  ? 172.234 125.648 141.506 1.00 91.49  ? 1189 GLU A CD    1 
ATOM   3465 O  OE1   . GLU A 1 844  ? 173.317 125.093 141.238 1.00 91.26  ? 1189 GLU A OE1   1 
ATOM   3466 O  OE2   . GLU A 1 844  ? 171.785 125.729 142.669 1.00 92.64  ? 1189 GLU A OE2   1 
ATOM   3467 N  N     . ASP A 1 845  ? 168.043 127.218 140.438 1.00 84.12  ? 1190 ASP A N     1 
ATOM   3468 C  CA    . ASP A 1 845  ? 166.674 127.193 140.923 1.00 82.65  ? 1190 ASP A CA    1 
ATOM   3469 C  C     . ASP A 1 845  ? 166.677 127.355 142.434 1.00 86.84  ? 1190 ASP A C     1 
ATOM   3470 O  O     . ASP A 1 845  ? 167.619 126.944 143.116 1.00 94.08  ? 1190 ASP A O     1 
ATOM   3471 C  CB    . ASP A 1 845  ? 165.978 125.895 140.522 1.00 88.11  ? 1190 ASP A CB    1 
ATOM   3472 C  CG    . ASP A 1 845  ? 164.485 126.072 140.345 1.00 91.68  ? 1190 ASP A CG    1 
ATOM   3473 O  OD1   . ASP A 1 845  ? 164.013 127.224 140.415 1.00 88.07  ? 1190 ASP A OD1   1 
ATOM   3474 O  OD2   . ASP A 1 845  ? 163.782 125.069 140.117 1.00 96.00  ? 1190 ASP A OD2   1 
ATOM   3475 N  N     . CYS A 1 846  ? 165.626 127.989 142.958 1.00 77.84  ? 1191 CYS A N     1 
ATOM   3476 C  CA    . CYS A 1 846  ? 165.554 128.185 144.401 1.00 78.66  ? 1191 CYS A CA    1 
ATOM   3477 C  C     . CYS A 1 846  ? 165.485 126.847 145.119 1.00 74.71  ? 1191 CYS A C     1 
ATOM   3478 O  O     . CYS A 1 846  ? 166.137 126.652 146.151 1.00 72.79  ? 1191 CYS A O     1 
ATOM   3479 C  CB    . CYS A 1 846  ? 164.354 129.056 144.772 1.00 79.53  ? 1191 CYS A CB    1 
ATOM   3480 S  SG    . CYS A 1 846  ? 162.898 128.857 143.724 1.00 94.31  ? 1191 CYS A SG    1 
ATOM   3481 N  N     . ASN A 1 847  ? 164.705 125.908 144.580 1.00 76.79  ? 1192 ASN A N     1 
ATOM   3482 C  CA    . ASN A 1 847  ? 164.593 124.597 145.204 1.00 77.46  ? 1192 ASN A CA    1 
ATOM   3483 C  C     . ASN A 1 847  ? 165.928 123.864 145.201 1.00 73.46  ? 1192 ASN A C     1 
ATOM   3484 O  O     . ASN A 1 847  ? 166.312 123.262 146.209 1.00 74.32  ? 1192 ASN A O     1 
ATOM   3485 C  CB    . ASN A 1 847  ? 163.523 123.768 144.498 1.00 77.30  ? 1192 ASN A CB    1 
ATOM   3486 C  CG    . ASN A 1 847  ? 162.302 124.585 144.134 1.00 77.31  ? 1192 ASN A CG    1 
ATOM   3487 O  OD1   . ASN A 1 847  ? 161.827 125.400 144.923 1.00 76.84  ? 1192 ASN A OD1   1 
ATOM   3488 N  ND2   . ASN A 1 847  ? 161.779 124.359 142.937 1.00 77.60  ? 1192 ASN A ND2   1 
ATOM   3489 N  N     . ILE A 1 848  ? 166.654 123.906 144.082 1.00 73.43  ? 1193 ILE A N     1 
ATOM   3490 C  CA    . ILE A 1 848  ? 167.938 123.214 144.015 1.00 77.01  ? 1193 ILE A CA    1 
ATOM   3491 C  C     . ILE A 1 848  ? 168.919 123.815 145.012 1.00 76.44  ? 1193 ILE A C     1 
ATOM   3492 O  O     . ILE A 1 848  ? 169.626 123.090 145.723 1.00 82.06  ? 1193 ILE A O     1 
ATOM   3493 C  CB    . ILE A 1 848  ? 168.498 123.244 142.581 1.00 76.91  ? 1193 ILE A CB    1 
ATOM   3494 C  CG1   . ILE A 1 848  ? 167.446 122.752 141.587 1.00 77.15  ? 1193 ILE A CG1   1 
ATOM   3495 C  CG2   . ILE A 1 848  ? 169.762 122.405 142.485 1.00 74.88  ? 1193 ILE A CG2   1 
ATOM   3496 C  CD1   . ILE A 1 848  ? 167.942 122.681 140.162 1.00 76.13  ? 1193 ILE A CD1   1 
ATOM   3497 N  N     . LEU A 1 849  ? 168.970 125.145 145.092 1.00 65.76  ? 1194 LEU A N     1 
ATOM   3498 C  CA    . LEU A 1 849  ? 169.893 125.790 146.018 1.00 69.34  ? 1194 LEU A CA    1 
ATOM   3499 C  C     . LEU A 1 849  ? 169.530 125.484 147.467 1.00 71.20  ? 1194 LEU A C     1 
ATOM   3500 O  O     . LEU A 1 849  ? 170.412 125.238 148.296 1.00 70.15  ? 1194 LEU A O     1 
ATOM   3501 C  CB    . LEU A 1 849  ? 169.914 127.296 145.774 1.00 69.87  ? 1194 LEU A CB    1 
ATOM   3502 C  CG    . LEU A 1 849  ? 171.062 128.050 146.443 1.00 71.81  ? 1194 LEU A CG    1 
ATOM   3503 C  CD1   . LEU A 1 849  ? 171.740 128.967 145.444 1.00 64.89  ? 1194 LEU A CD1   1 
ATOM   3504 C  CD2   . LEU A 1 849  ? 170.567 128.834 147.643 1.00 69.10  ? 1194 LEU A CD2   1 
ATOM   3505 N  N     . LEU A 1 850  ? 168.236 125.498 147.794 1.00 70.35  ? 1195 LEU A N     1 
ATOM   3506 C  CA    . LEU A 1 850  ? 167.827 125.186 149.159 1.00 70.32  ? 1195 LEU A CA    1 
ATOM   3507 C  C     . LEU A 1 850  ? 168.157 123.745 149.519 1.00 70.66  ? 1195 LEU A C     1 
ATOM   3508 O  O     . LEU A 1 850  ? 168.662 123.469 150.614 1.00 72.83  ? 1195 LEU A O     1 
ATOM   3509 C  CB    . LEU A 1 850  ? 166.334 125.450 149.336 1.00 66.89  ? 1195 LEU A CB    1 
ATOM   3510 C  CG    . LEU A 1 850  ? 165.831 125.357 150.775 1.00 62.38  ? 1195 LEU A CG    1 
ATOM   3511 C  CD1   . LEU A 1 850  ? 166.615 126.288 151.678 1.00 61.73  ? 1195 LEU A CD1   1 
ATOM   3512 C  CD2   . LEU A 1 850  ? 164.351 125.663 150.838 1.00 65.07  ? 1195 LEU A CD2   1 
ATOM   3513 N  N     . LYS A 1 851  ? 167.880 122.809 148.609 1.00 66.79  ? 1196 LYS A N     1 
ATOM   3514 C  CA    . LYS A 1 851  ? 168.214 121.413 148.863 1.00 68.86  ? 1196 LYS A CA    1 
ATOM   3515 C  C     . LYS A 1 851  ? 169.716 121.240 149.029 1.00 70.49  ? 1196 LYS A C     1 
ATOM   3516 O  O     . LYS A 1 851  ? 170.171 120.424 149.839 1.00 71.43  ? 1196 LYS A O     1 
ATOM   3517 C  CB    . LYS A 1 851  ? 167.689 120.538 147.727 1.00 71.46  ? 1196 LYS A CB    1 
ATOM   3518 C  CG    . LYS A 1 851  ? 166.532 119.641 148.118 1.00 71.89  ? 1196 LYS A CG    1 
ATOM   3519 C  CD    . LYS A 1 851  ? 166.303 118.564 147.074 1.00 71.35  ? 1196 LYS A CD    1 
ATOM   3520 C  CE    . LYS A 1 851  ? 167.489 117.621 146.990 1.00 70.69  ? 1196 LYS A CE    1 
ATOM   3521 N  NZ    . LYS A 1 851  ? 167.125 116.333 146.341 1.00 74.24  ? 1196 LYS A NZ    1 
ATOM   3522 N  N     . LEU A 1 852  ? 170.502 121.998 148.265 1.00 72.01  ? 1197 LEU A N     1 
ATOM   3523 C  CA    . LEU A 1 852  ? 171.948 121.955 148.422 1.00 69.59  ? 1197 LEU A CA    1 
ATOM   3524 C  C     . LEU A 1 852  ? 172.372 122.488 149.785 1.00 73.06  ? 1197 LEU A C     1 
ATOM   3525 O  O     . LEU A 1 852  ? 173.294 121.949 150.408 1.00 78.34  ? 1197 LEU A O     1 
ATOM   3526 C  CB    . LEU A 1 852  ? 172.614 122.749 147.301 1.00 68.44  ? 1197 LEU A CB    1 
ATOM   3527 C  CG    . LEU A 1 852  ? 174.135 122.669 147.211 1.00 74.29  ? 1197 LEU A CG    1 
ATOM   3528 C  CD1   . LEU A 1 852  ? 174.551 121.393 146.504 1.00 73.82  ? 1197 LEU A CD1   1 
ATOM   3529 C  CD2   . LEU A 1 852  ? 174.680 123.885 146.488 1.00 76.66  ? 1197 LEU A CD2   1 
ATOM   3530 N  N     . VAL A 1 853  ? 171.711 123.545 150.266 1.00 67.38  ? 1198 VAL A N     1 
ATOM   3531 C  CA    . VAL A 1 853  ? 172.132 124.172 151.519 1.00 68.05  ? 1198 VAL A CA    1 
ATOM   3532 C  C     . VAL A 1 853  ? 171.575 123.470 152.747 1.00 63.10  ? 1198 VAL A C     1 
ATOM   3533 O  O     . VAL A 1 853  ? 172.014 123.767 153.865 1.00 61.47  ? 1198 VAL A O     1 
ATOM   3534 C  CB    . VAL A 1 853  ? 171.741 125.662 151.557 1.00 62.87  ? 1198 VAL A CB    1 
ATOM   3535 C  CG1   . VAL A 1 853  ? 170.274 125.828 151.899 1.00 63.74  ? 1198 VAL A CG1   1 
ATOM   3536 C  CG2   . VAL A 1 853  ? 172.630 126.435 152.528 1.00 60.92  ? 1198 VAL A CG2   1 
ATOM   3537 N  N     . MET A 1 854  ? 170.623 122.547 152.583 1.00 60.13  ? 1199 MET A N     1 
ATOM   3538 C  CA    . MET A 1 854  ? 170.227 121.711 153.714 1.00 62.81  ? 1199 MET A CA    1 
ATOM   3539 C  C     . MET A 1 854  ? 171.428 120.965 154.280 1.00 61.79  ? 1199 MET A C     1 
ATOM   3540 O  O     . MET A 1 854  ? 171.644 120.942 155.497 1.00 63.64  ? 1199 MET A O     1 
ATOM   3541 C  CB    . MET A 1 854  ? 169.130 120.726 153.305 1.00 65.94  ? 1199 MET A CB    1 
ATOM   3542 C  CG    . MET A 1 854  ? 167.862 121.362 152.774 1.00 66.44  ? 1199 MET A CG    1 
ATOM   3543 S  SD    . MET A 1 854  ? 166.632 121.560 154.074 1.00 55.10  ? 1199 MET A SD    1 
ATOM   3544 C  CE    . MET A 1 854  ? 165.618 122.860 153.390 1.00 53.31  ? 1199 MET A CE    1 
ATOM   3545 N  N     . ALA A 1 855  ? 172.224 120.354 153.410 1.00 68.29  ? 1200 ALA A N     1 
ATOM   3546 C  CA    . ALA A 1 855  ? 173.482 119.767 153.833 1.00 70.03  ? 1200 ALA A CA    1 
ATOM   3547 C  C     . ALA A 1 855  ? 174.562 120.841 153.907 1.00 73.25  ? 1200 ALA A C     1 
ATOM   3548 O  O     . ALA A 1 855  ? 174.469 121.898 153.279 1.00 76.74  ? 1200 ALA A O     1 
ATOM   3549 C  CB    . ALA A 1 855  ? 173.909 118.656 152.875 1.00 71.36  ? 1200 ALA A CB    1 
ATOM   3550 N  N     . GLY A 1 856  ? 175.604 120.556 154.683 1.00 83.81  ? 1201 GLY A N     1 
ATOM   3551 C  CA    . GLY A 1 856  ? 176.687 121.505 154.850 1.00 86.66  ? 1201 GLY A CA    1 
ATOM   3552 C  C     . GLY A 1 856  ? 177.574 121.614 153.627 1.00 87.32  ? 1201 GLY A C     1 
ATOM   3553 O  O     . GLY A 1 856  ? 178.786 121.390 153.707 1.00 86.47  ? 1201 GLY A O     1 
ATOM   3554 N  N     . GLU A 1 857  ? 176.978 121.960 152.483 1.00 87.42  ? 1202 GLU A N     1 
ATOM   3555 C  CA    . GLU A 1 857  ? 177.736 121.996 151.237 1.00 89.57  ? 1202 GLU A CA    1 
ATOM   3556 C  C     . GLU A 1 857  ? 178.667 123.200 151.185 1.00 90.72  ? 1202 GLU A C     1 
ATOM   3557 O  O     . GLU A 1 857  ? 179.797 123.091 150.695 1.00 91.88  ? 1202 GLU A O     1 
ATOM   3558 C  CB    . GLU A 1 857  ? 176.778 122.005 150.047 1.00 89.15  ? 1202 GLU A CB    1 
ATOM   3559 C  CG    . GLU A 1 857  ? 176.189 120.643 149.716 1.00 89.00  ? 1202 GLU A CG    1 
ATOM   3560 C  CD    . GLU A 1 857  ? 177.081 119.828 148.804 1.00 94.34  ? 1202 GLU A CD    1 
ATOM   3561 O  OE1   . GLU A 1 857  ? 177.447 120.333 147.722 1.00 94.78  ? 1202 GLU A OE1   1 
ATOM   3562 O  OE2   . GLU A 1 857  ? 177.419 118.681 149.168 1.00 93.16  ? 1202 GLU A OE2   1 
ATOM   3563 N  N     . THR A 1 858  ? 178.183 124.366 151.627 1.00 87.44  ? 1203 THR A N     1 
ATOM   3564 C  CA    . THR A 1 858  ? 178.903 125.639 151.750 1.00 89.79  ? 1203 THR A CA    1 
ATOM   3565 C  C     . THR A 1 858  ? 179.703 125.997 150.499 1.00 91.12  ? 1203 THR A C     1 
ATOM   3566 O  O     . THR A 1 858  ? 180.605 126.838 150.561 1.00 92.59  ? 1203 THR A O     1 
ATOM   3567 C  CB    . THR A 1 858  ? 179.820 125.692 152.991 1.00 89.33  ? 1203 THR A CB    1 
ATOM   3568 O  OG1   . THR A 1 858  ? 180.556 126.921 152.974 1.00 88.80  ? 1203 THR A OG1   1 
ATOM   3569 C  CG2   . THR A 1 858  ? 180.828 124.554 153.054 1.00 89.54  ? 1203 THR A CG2   1 
ATOM   3570 N  N     . THR A 1 859  ? 179.375 125.377 149.367 1.00 89.65  ? 1204 THR A N     1 
ATOM   3571 C  CA    . THR A 1 859  ? 179.974 125.729 148.080 1.00 89.70  ? 1204 THR A CA    1 
ATOM   3572 C  C     . THR A 1 859  ? 179.144 125.071 146.990 1.00 88.31  ? 1204 THR A C     1 
ATOM   3573 O  O     . THR A 1 859  ? 178.956 123.851 147.013 1.00 89.46  ? 1204 THR A O     1 
ATOM   3574 C  CB    . THR A 1 859  ? 181.433 125.275 148.000 1.00 92.58  ? 1204 THR A CB    1 
ATOM   3575 O  OG1   . THR A 1 859  ? 182.255 126.172 148.758 1.00 96.03  ? 1204 THR A OG1   1 
ATOM   3576 C  CG2   . THR A 1 859  ? 181.912 125.266 146.558 1.00 88.83  ? 1204 THR A CG2   1 
ATOM   3577 N  N     . ASN A 1 860  ? 178.653 125.864 146.043 1.00 87.30  ? 1205 ASN A N     1 
ATOM   3578 C  CA    . ASN A 1 860  ? 177.850 125.333 144.952 1.00 90.91  ? 1205 ASN A CA    1 
ATOM   3579 C  C     . ASN A 1 860  ? 178.768 124.889 143.814 1.00 93.23  ? 1205 ASN A C     1 
ATOM   3580 O  O     . ASN A 1 860  ? 179.993 124.851 143.952 1.00 91.42  ? 1205 ASN A O     1 
ATOM   3581 C  CB    . ASN A 1 860  ? 176.821 126.367 144.499 1.00 84.36  ? 1205 ASN A CB    1 
ATOM   3582 C  CG    . ASN A 1 860  ? 177.454 127.678 144.091 1.00 87.42  ? 1205 ASN A CG    1 
ATOM   3583 O  OD1   . ASN A 1 860  ? 178.639 127.906 144.323 1.00 86.89  ? 1205 ASN A OD1   1 
ATOM   3584 N  ND2   . ASN A 1 860  ? 176.663 128.551 143.480 1.00 89.63  ? 1205 ASN A ND2   1 
ATOM   3585 N  N     . SER A 1 861  ? 178.180 124.543 142.668 1.00 92.45  ? 1206 SER A N     1 
ATOM   3586 C  CA    . SER A 1 861  ? 178.967 124.045 141.547 1.00 90.19  ? 1206 SER A CA    1 
ATOM   3587 C  C     . SER A 1 861  ? 179.837 125.123 140.913 1.00 87.69  ? 1206 SER A C     1 
ATOM   3588 O  O     . SER A 1 861  ? 180.808 124.790 140.227 1.00 89.99  ? 1206 SER A O     1 
ATOM   3589 C  CB    . SER A 1 861  ? 178.046 123.435 140.491 1.00 92.10  ? 1206 SER A CB    1 
ATOM   3590 O  OG    . SER A 1 861  ? 176.899 124.241 140.289 1.00 89.40  ? 1206 SER A OG    1 
ATOM   3591 N  N     . ARG A 1 862  ? 179.516 126.398 141.122 1.00 85.08  ? 1207 ARG A N     1 
ATOM   3592 C  CA    . ARG A 1 862  ? 180.256 127.500 140.523 1.00 86.88  ? 1207 ARG A CA    1 
ATOM   3593 C  C     . ARG A 1 862  ? 181.256 128.133 141.481 1.00 87.00  ? 1207 ARG A C     1 
ATOM   3594 O  O     . ARG A 1 862  ? 181.810 129.192 141.171 1.00 88.43  ? 1207 ARG A O     1 
ATOM   3595 C  CB    . ARG A 1 862  ? 179.287 128.562 140.000 1.00 86.37  ? 1207 ARG A CB    1 
ATOM   3596 C  CG    . ARG A 1 862  ? 178.776 128.297 138.594 1.00 85.02  ? 1207 ARG A CG    1 
ATOM   3597 C  CD    . ARG A 1 862  ? 177.578 127.363 138.608 1.00 87.28  ? 1207 ARG A CD    1 
ATOM   3598 N  NE    . ARG A 1 862  ? 176.556 127.773 137.653 1.00 90.00  ? 1207 ARG A NE    1 
ATOM   3599 C  CZ    . ARG A 1 862  ? 175.482 128.485 137.967 1.00 88.94  ? 1207 ARG A CZ    1 
ATOM   3600 N  NH1   . ARG A 1 862  ? 175.260 128.888 139.207 1.00 85.21  ? 1207 ARG A NH1   1 
ATOM   3601 N  NH2   . ARG A 1 862  ? 174.612 128.801 137.013 1.00 85.27  ? 1207 ARG A NH2   1 
ATOM   3602 N  N     . GLY A 1 863  ? 181.498 127.517 142.634 1.00 84.04  ? 1208 GLY A N     1 
ATOM   3603 C  CA    . GLY A 1 863  ? 182.475 128.046 143.563 1.00 83.83  ? 1208 GLY A CA    1 
ATOM   3604 C  C     . GLY A 1 863  ? 182.024 129.256 144.347 1.00 83.97  ? 1208 GLY A C     1 
ATOM   3605 O  O     . GLY A 1 863  ? 182.865 130.005 144.852 1.00 87.51  ? 1208 GLY A O     1 
ATOM   3606 N  N     . GLN A 1 864  ? 180.719 129.471 144.465 1.00 78.36  ? 1209 GLN A N     1 
ATOM   3607 C  CA    . GLN A 1 864  ? 180.175 130.571 145.246 1.00 77.66  ? 1209 GLN A CA    1 
ATOM   3608 C  C     . GLN A 1 864  ? 179.767 130.077 146.628 1.00 77.82  ? 1209 GLN A C     1 
ATOM   3609 O  O     . GLN A 1 864  ? 179.440 128.904 146.817 1.00 79.65  ? 1209 GLN A O     1 
ATOM   3610 C  CB    . GLN A 1 864  ? 178.976 131.205 144.538 1.00 75.15  ? 1209 GLN A CB    1 
ATOM   3611 C  CG    . GLN A 1 864  ? 179.351 132.266 143.516 1.00 75.89  ? 1209 GLN A CG    1 
ATOM   3612 C  CD    . GLN A 1 864  ? 178.234 132.553 142.536 1.00 76.19  ? 1209 GLN A CD    1 
ATOM   3613 O  OE1   . GLN A 1 864  ? 177.433 131.676 142.216 1.00 73.19  ? 1209 GLN A OE1   1 
ATOM   3614 N  NE2   . GLN A 1 864  ? 178.176 133.786 142.050 1.00 74.50  ? 1209 GLN A NE2   1 
ATOM   3615 N  N     . ARG A 1 865  ? 179.793 130.988 147.596 1.00 80.80  ? 1210 ARG A N     1 
ATOM   3616 C  CA    . ARG A 1 865  ? 179.525 130.649 148.987 1.00 79.26  ? 1210 ARG A CA    1 
ATOM   3617 C  C     . ARG A 1 865  ? 178.044 130.855 149.286 1.00 78.44  ? 1210 ARG A C     1 
ATOM   3618 O  O     . ARG A 1 865  ? 177.536 131.976 149.181 1.00 78.19  ? 1210 ARG A O     1 
ATOM   3619 C  CB    . ARG A 1 865  ? 180.391 131.501 149.913 1.00 78.62  ? 1210 ARG A CB    1 
ATOM   3620 C  CG    . ARG A 1 865  ? 179.841 131.678 151.315 1.00 78.24  ? 1210 ARG A CG    1 
ATOM   3621 C  CD    . ARG A 1 865  ? 179.970 130.394 152.119 1.00 80.80  ? 1210 ARG A CD    1 
ATOM   3622 N  NE    . ARG A 1 865  ? 181.353 130.107 152.480 1.00 84.93  ? 1210 ARG A NE    1 
ATOM   3623 C  CZ    . ARG A 1 865  ? 182.048 130.776 153.390 1.00 84.51  ? 1210 ARG A CZ    1 
ATOM   3624 N  NH1   . ARG A 1 865  ? 181.514 131.776 154.072 1.00 80.59  ? 1210 ARG A NH1   1 
ATOM   3625 N  NH2   . ARG A 1 865  ? 183.310 130.429 153.627 1.00 83.59  ? 1210 ARG A NH2   1 
ATOM   3626 N  N     . LEU A 1 866  ? 177.351 129.773 149.650 1.00 71.34  ? 1211 LEU A N     1 
ATOM   3627 C  CA    . LEU A 1 866  ? 175.962 129.890 150.062 1.00 69.21  ? 1211 LEU A CA    1 
ATOM   3628 C  C     . LEU A 1 866  ? 175.870 130.471 151.471 1.00 68.76  ? 1211 LEU A C     1 
ATOM   3629 O  O     . LEU A 1 866  ? 176.787 130.306 152.278 1.00 71.60  ? 1211 LEU A O     1 
ATOM   3630 C  CB    . LEU A 1 866  ? 175.256 128.534 150.023 1.00 69.71  ? 1211 LEU A CB    1 
ATOM   3631 C  CG    . LEU A 1 866  ? 175.300 127.609 148.804 1.00 72.05  ? 1211 LEU A CG    1 
ATOM   3632 C  CD1   . LEU A 1 866  ? 176.625 126.900 148.654 1.00 73.07  ? 1211 LEU A CD1   1 
ATOM   3633 C  CD2   . LEU A 1 866  ? 174.165 126.603 148.883 1.00 69.26  ? 1211 LEU A CD2   1 
ATOM   3634 N  N     . PRO A 1 867  ? 174.771 131.154 151.794 1.00 58.50  ? 1212 PRO A N     1 
ATOM   3635 C  CA    . PRO A 1 867  ? 174.644 131.754 153.128 1.00 62.75  ? 1212 PRO A CA    1 
ATOM   3636 C  C     . PRO A 1 867  ? 174.245 130.707 154.158 1.00 64.30  ? 1212 PRO A C     1 
ATOM   3637 O  O     . PRO A 1 867  ? 173.330 129.912 153.933 1.00 69.00  ? 1212 PRO A O     1 
ATOM   3638 C  CB    . PRO A 1 867  ? 173.547 132.807 152.945 1.00 64.20  ? 1212 PRO A CB    1 
ATOM   3639 C  CG    . PRO A 1 867  ? 172.759 132.353 151.757 1.00 63.25  ? 1212 PRO A CG    1 
ATOM   3640 C  CD    . PRO A 1 867  ? 173.566 131.361 150.972 1.00 58.19  ? 1212 PRO A CD    1 
ATOM   3641 N  N     . GLN A 1 868  ? 174.939 130.710 155.291 1.00 66.55  ? 1213 GLN A N     1 
ATOM   3642 C  CA    . GLN A 1 868  ? 174.691 129.749 156.352 1.00 65.62  ? 1213 GLN A CA    1 
ATOM   3643 C  C     . GLN A 1 868  ? 173.673 130.294 157.349 1.00 66.31  ? 1213 GLN A C     1 
ATOM   3644 O  O     . GLN A 1 868  ? 173.311 131.471 157.329 1.00 67.53  ? 1213 GLN A O     1 
ATOM   3645 C  CB    . GLN A 1 868  ? 175.994 129.394 157.068 1.00 62.31  ? 1213 GLN A CB    1 
ATOM   3646 C  CG    . GLN A 1 868  ? 177.089 128.839 156.168 1.00 64.82  ? 1213 GLN A CG    1 
ATOM   3647 C  CD    . GLN A 1 868  ? 176.837 127.411 155.719 1.00 70.52  ? 1213 GLN A CD    1 
ATOM   3648 O  OE1   . GLN A 1 868  ? 175.695 126.983 155.550 1.00 72.48  ? 1213 GLN A OE1   1 
ATOM   3649 N  NE2   . GLN A 1 868  ? 177.913 126.660 155.532 1.00 68.96  ? 1213 GLN A NE2   1 
ATOM   3650 N  N     . LYS A 1 869  ? 173.207 129.413 158.231 1.00 62.49  ? 1214 LYS A N     1 
ATOM   3651 C  CA    . LYS A 1 869  ? 172.292 129.831 159.283 1.00 63.53  ? 1214 LYS A CA    1 
ATOM   3652 C  C     . LYS A 1 869  ? 172.988 130.798 160.229 1.00 63.66  ? 1214 LYS A C     1 
ATOM   3653 O  O     . LYS A 1 869  ? 174.153 130.611 160.590 1.00 70.40  ? 1214 LYS A O     1 
ATOM   3654 C  CB    . LYS A 1 869  ? 171.773 128.617 160.054 1.00 61.15  ? 1214 LYS A CB    1 
ATOM   3655 C  CG    . LYS A 1 869  ? 170.855 127.721 159.246 1.00 61.36  ? 1214 LYS A CG    1 
ATOM   3656 C  CD    . LYS A 1 869  ? 170.641 126.382 159.927 1.00 63.68  ? 1214 LYS A CD    1 
ATOM   3657 C  CE    . LYS A 1 869  ? 169.886 126.545 161.232 1.00 63.01  ? 1214 LYS A CE    1 
ATOM   3658 N  NZ    . LYS A 1 869  ? 168.642 127.339 161.052 1.00 62.78  ? 1214 LYS A NZ    1 
ATOM   3659 N  N     . GLY A 1 870  ? 172.267 131.838 160.630 1.00 46.18  ? 1215 GLY A N     1 
ATOM   3660 C  CA    . GLY A 1 870  ? 172.847 132.894 161.426 1.00 49.78  ? 1215 GLY A CA    1 
ATOM   3661 C  C     . GLY A 1 870  ? 173.585 133.949 160.636 1.00 55.00  ? 1215 GLY A C     1 
ATOM   3662 O  O     . GLY A 1 870  ? 174.097 134.902 161.236 1.00 58.46  ? 1215 GLY A O     1 
ATOM   3663 N  N     . ASP A 1 871  ? 173.663 133.811 159.314 1.00 57.70  ? 1216 ASP A N     1 
ATOM   3664 C  CA    . ASP A 1 871  ? 174.286 134.809 158.459 1.00 53.38  ? 1216 ASP A CA    1 
ATOM   3665 C  C     . ASP A 1 871  ? 173.276 135.636 157.678 1.00 50.60  ? 1216 ASP A C     1 
ATOM   3666 O  O     . ASP A 1 871  ? 173.675 136.579 156.989 1.00 60.89  ? 1216 ASP A O     1 
ATOM   3667 C  CB    . ASP A 1 871  ? 175.257 134.139 157.480 1.00 55.18  ? 1216 ASP A CB    1 
ATOM   3668 C  CG    . ASP A 1 871  ? 176.625 134.789 157.482 1.00 62.18  ? 1216 ASP A CG    1 
ATOM   3669 O  OD1   . ASP A 1 871  ? 176.693 136.032 157.585 1.00 63.56  ? 1216 ASP A OD1   1 
ATOM   3670 O  OD2   . ASP A 1 871  ? 177.633 134.059 157.377 1.00 62.44  ? 1216 ASP A OD2   1 
ATOM   3671 N  N     . VAL A 1 872  ? 171.991 135.309 157.766 1.00 36.32  ? 1217 VAL A N     1 
ATOM   3672 C  CA    . VAL A 1 872  ? 170.929 136.054 157.104 1.00 34.79  ? 1217 VAL A CA    1 
ATOM   3673 C  C     . VAL A 1 872  ? 170.080 136.715 158.177 1.00 42.88  ? 1217 VAL A C     1 
ATOM   3674 O  O     . VAL A 1 872  ? 169.607 136.044 159.101 1.00 47.14  ? 1217 VAL A O     1 
ATOM   3675 C  CB    . VAL A 1 872  ? 170.072 135.142 156.211 1.00 26.71  ? 1217 VAL A CB    1 
ATOM   3676 C  CG1   . VAL A 1 872  ? 168.747 135.804 155.893 1.00 25.40  ? 1217 VAL A CG1   1 
ATOM   3677 C  CG2   . VAL A 1 872  ? 170.814 134.813 154.938 1.00 47.89  ? 1217 VAL A CG2   1 
ATOM   3678 N  N     . GLU A 1 873  ? 169.892 138.028 158.061 1.00 48.91  ? 1218 GLU A N     1 
ATOM   3679 C  CA    . GLU A 1 873  ? 169.093 138.774 159.022 1.00 43.34  ? 1218 GLU A CA    1 
ATOM   3680 C  C     . GLU A 1 873  ? 167.806 139.337 158.446 1.00 39.29  ? 1218 GLU A C     1 
ATOM   3681 O  O     . GLU A 1 873  ? 166.852 139.542 159.196 1.00 45.00  ? 1218 GLU A O     1 
ATOM   3682 C  CB    . GLU A 1 873  ? 169.912 139.922 159.620 1.00 42.64  ? 1218 GLU A CB    1 
ATOM   3683 C  CG    . GLU A 1 873  ? 171.092 139.463 160.448 1.00 47.54  ? 1218 GLU A CG    1 
ATOM   3684 C  CD    . GLU A 1 873  ? 171.816 140.612 161.116 1.00 58.75  ? 1218 GLU A CD    1 
ATOM   3685 O  OE1   . GLU A 1 873  ? 171.314 141.753 161.049 1.00 64.64  ? 1218 GLU A OE1   1 
ATOM   3686 O  OE2   . GLU A 1 873  ? 172.888 140.376 161.709 1.00 59.73  ? 1218 GLU A OE2   1 
ATOM   3687 N  N     . MET A 1 874  ? 167.751 139.592 157.142 1.00 34.52  ? 1219 MET A N     1 
ATOM   3688 C  CA    . MET A 1 874  ? 166.551 140.109 156.500 1.00 29.17  ? 1219 MET A CA    1 
ATOM   3689 C  C     . MET A 1 874  ? 166.283 139.317 155.234 1.00 39.09  ? 1219 MET A C     1 
ATOM   3690 O  O     . MET A 1 874  ? 167.081 139.366 154.295 1.00 61.02  ? 1219 MET A O     1 
ATOM   3691 C  CB    . MET A 1 874  ? 166.698 141.591 156.153 1.00 45.14  ? 1219 MET A CB    1 
ATOM   3692 C  CG    . MET A 1 874  ? 165.571 142.111 155.284 1.00 43.28  ? 1219 MET A CG    1 
ATOM   3693 S  SD    . MET A 1 874  ? 164.188 142.654 156.290 1.00 74.14  ? 1219 MET A SD    1 
ATOM   3694 C  CE    . MET A 1 874  ? 163.014 143.164 155.051 1.00 46.83  ? 1219 MET A CE    1 
ATOM   3695 N  N     . LEU A 1 875  ? 165.159 138.610 155.191 1.00 27.36  ? 1220 LEU A N     1 
ATOM   3696 C  CA    . LEU A 1 875  ? 164.791 137.831 154.012 1.00 33.03  ? 1220 LEU A CA    1 
ATOM   3697 C  C     . LEU A 1 875  ? 163.623 138.524 153.329 1.00 30.82  ? 1220 LEU A C     1 
ATOM   3698 O  O     . LEU A 1 875  ? 162.529 138.614 153.895 1.00 51.00  ? 1220 LEU A O     1 
ATOM   3699 C  CB    . LEU A 1 875  ? 164.437 136.394 154.381 1.00 33.34  ? 1220 LEU A CB    1 
ATOM   3700 C  CG    . LEU A 1 875  ? 163.916 135.543 153.227 1.00 35.25  ? 1220 LEU A CG    1 
ATOM   3701 C  CD1   . LEU A 1 875  ? 165.056 134.815 152.558 1.00 38.32  ? 1220 LEU A CD1   1 
ATOM   3702 C  CD2   . LEU A 1 875  ? 162.894 134.557 153.729 1.00 39.29  ? 1220 LEU A CD2   1 
ATOM   3703 N  N     . CYS A 1 876  ? 163.849 139.006 152.114 1.00 28.36  ? 1221 CYS A N     1 
ATOM   3704 C  CA    . CYS A 1 876  ? 162.833 139.769 151.410 1.00 35.34  ? 1221 CYS A CA    1 
ATOM   3705 C  C     . CYS A 1 876  ? 162.650 139.227 150.003 1.00 41.32  ? 1221 CYS A C     1 
ATOM   3706 O  O     . CYS A 1 876  ? 163.576 138.664 149.413 1.00 49.27  ? 1221 CYS A O     1 
ATOM   3707 C  CB    . CYS A 1 876  ? 163.194 141.258 151.353 1.00 42.59  ? 1221 CYS A CB    1 
ATOM   3708 S  SG    . CYS A 1 876  ? 164.650 141.655 150.365 1.00 65.97  ? 1221 CYS A SG    1 
ATOM   3709 N  N     . GLY A 1 877  ? 161.445 139.387 149.473 1.00 40.21  ? 1222 GLY A N     1 
ATOM   3710 C  CA    . GLY A 1 877  ? 161.233 139.038 148.080 1.00 48.33  ? 1222 GLY A CA    1 
ATOM   3711 C  C     . GLY A 1 877  ? 159.768 139.021 147.713 1.00 54.49  ? 1222 GLY A C     1 
ATOM   3712 O  O     . GLY A 1 877  ? 158.884 139.276 148.538 1.00 65.44  ? 1222 GLY A O     1 
ATOM   3713 N  N     . GLY A 1 878  ? 159.528 138.740 146.437 1.00 51.51  ? 1223 GLY A N     1 
ATOM   3714 C  CA    . GLY A 1 878  ? 158.192 138.555 145.935 1.00 47.60  ? 1223 GLY A CA    1 
ATOM   3715 C  C     . GLY A 1 878  ? 158.099 137.370 145.000 1.00 55.91  ? 1223 GLY A C     1 
ATOM   3716 O  O     . GLY A 1 878  ? 158.717 137.344 143.933 1.00 59.83  ? 1223 GLY A O     1 
ATOM   3717 N  N     . PRO A 1 879  ? 157.307 136.369 145.378 1.00 54.90  ? 1224 PRO A N     1 
ATOM   3718 C  CA    . PRO A 1 879  ? 157.158 135.199 144.522 1.00 46.45  ? 1224 PRO A CA    1 
ATOM   3719 C  C     . PRO A 1 879  ? 156.488 135.576 143.216 1.00 53.82  ? 1224 PRO A C     1 
ATOM   3720 O  O     . PRO A 1 879  ? 155.834 136.630 143.116 1.00 64.33  ? 1224 PRO A O     1 
ATOM   3721 C  CB    . PRO A 1 879  ? 156.275 134.261 145.357 1.00 47.56  ? 1224 PRO A CB    1 
ATOM   3722 C  CG    . PRO A 1 879  ? 156.417 134.735 146.752 1.00 59.94  ? 1224 PRO A CG    1 
ATOM   3723 C  CD    . PRO A 1 879  ? 156.618 136.208 146.666 1.00 58.83  ? 1224 PRO A CD    1 
ATOM   3724 N  N     . PRO A 1 880  ? 156.646 134.756 142.178 1.00 58.12  ? 1225 PRO A N     1 
ATOM   3725 C  CA    . PRO A 1 880  ? 156.002 135.060 140.895 1.00 61.71  ? 1225 PRO A CA    1 
ATOM   3726 C  C     . PRO A 1 880  ? 154.495 135.202 141.046 1.00 65.51  ? 1225 PRO A C     1 
ATOM   3727 O  O     . PRO A 1 880  ? 153.820 134.330 141.597 1.00 62.35  ? 1225 PRO A O     1 
ATOM   3728 C  CB    . PRO A 1 880  ? 156.375 133.858 140.023 1.00 56.51  ? 1225 PRO A CB    1 
ATOM   3729 C  CG    . PRO A 1 880  ? 157.647 133.371 140.603 1.00 60.07  ? 1225 PRO A CG    1 
ATOM   3730 C  CD    . PRO A 1 880  ? 157.525 133.581 142.083 1.00 62.62  ? 1225 PRO A CD    1 
ATOM   3731 N  N     . CYS A 1 881  ? 153.975 136.321 140.551 1.00 68.26  ? 1226 CYS A N     1 
ATOM   3732 C  CA    . CYS A 1 881  ? 152.567 136.665 140.670 1.00 64.34  ? 1226 CYS A CA    1 
ATOM   3733 C  C     . CYS A 1 881  ? 151.791 136.414 139.389 1.00 67.37  ? 1226 CYS A C     1 
ATOM   3734 O  O     . CYS A 1 881  ? 150.645 136.858 139.276 1.00 73.28  ? 1226 CYS A O     1 
ATOM   3735 C  CB    . CYS A 1 881  ? 152.417 138.129 141.080 1.00 66.50  ? 1226 CYS A CB    1 
ATOM   3736 N  N     . GLN A 1 882  ? 152.390 135.726 138.417 1.00 66.38  ? 1227 GLN A N     1 
ATOM   3737 C  CA    . GLN A 1 882  ? 151.684 135.453 137.172 1.00 68.45  ? 1227 GLN A CA    1 
ATOM   3738 C  C     . GLN A 1 882  ? 150.513 134.506 137.387 1.00 71.74  ? 1227 GLN A C     1 
ATOM   3739 O  O     . GLN A 1 882  ? 149.517 134.576 136.658 1.00 75.20  ? 1227 GLN A O     1 
ATOM   3740 C  CB    . GLN A 1 882  ? 152.659 134.894 136.139 1.00 65.78  ? 1227 GLN A CB    1 
ATOM   3741 C  CG    . GLN A 1 882  ? 153.699 135.907 135.705 1.00 71.88  ? 1227 GLN A CG    1 
ATOM   3742 C  CD    . GLN A 1 882  ? 155.109 135.380 135.816 1.00 75.81  ? 1227 GLN A CD    1 
ATOM   3743 O  OE1   . GLN A 1 882  ? 155.338 134.176 135.740 1.00 77.45  ? 1227 GLN A OE1   1 
ATOM   3744 N  NE2   . GLN A 1 882  ? 156.065 136.280 136.003 1.00 73.82  ? 1227 GLN A NE2   1 
ATOM   3745 N  N     . GLY A 1 883  ? 150.607 133.619 138.378 1.00 65.14  ? 1228 GLY A N     1 
ATOM   3746 C  CA    . GLY A 1 883  ? 149.487 132.754 138.696 1.00 66.44  ? 1228 GLY A CA    1 
ATOM   3747 C  C     . GLY A 1 883  ? 148.443 133.383 139.590 1.00 67.57  ? 1228 GLY A C     1 
ATOM   3748 O  O     . GLY A 1 883  ? 147.290 132.940 139.582 1.00 70.72  ? 1228 GLY A O     1 
ATOM   3749 N  N     . PHE A 1 884  ? 148.816 134.404 140.360 1.00 60.76  ? 1229 PHE A N     1 
ATOM   3750 C  CA    . PHE A 1 884  ? 147.881 135.063 141.263 1.00 58.50  ? 1229 PHE A CA    1 
ATOM   3751 C  C     . PHE A 1 884  ? 147.077 136.162 140.587 1.00 58.72  ? 1229 PHE A C     1 
ATOM   3752 O  O     . PHE A 1 884  ? 145.963 136.462 141.029 1.00 64.29  ? 1229 PHE A O     1 
ATOM   3753 C  CB    . PHE A 1 884  ? 148.629 135.663 142.457 1.00 62.07  ? 1229 PHE A CB    1 
ATOM   3754 C  CG    . PHE A 1 884  ? 149.227 134.643 143.377 1.00 60.19  ? 1229 PHE A CG    1 
ATOM   3755 C  CD1   . PHE A 1 884  ? 148.422 133.779 144.095 1.00 58.45  ? 1229 PHE A CD1   1 
ATOM   3756 C  CD2   . PHE A 1 884  ? 150.597 134.554 143.531 1.00 56.17  ? 1229 PHE A CD2   1 
ATOM   3757 C  CE1   . PHE A 1 884  ? 148.973 132.844 144.942 1.00 57.26  ? 1229 PHE A CE1   1 
ATOM   3758 C  CE2   . PHE A 1 884  ? 151.152 133.620 144.376 1.00 57.44  ? 1229 PHE A CE2   1 
ATOM   3759 C  CZ    . PHE A 1 884  ? 150.339 132.766 145.083 1.00 59.64  ? 1229 PHE A CZ    1 
ATOM   3760 N  N     . SER A 1 885  ? 147.609 136.759 139.526 1.00 64.23  ? 1230 SER A N     1 
ATOM   3761 C  CA    . SER A 1 885  ? 147.013 137.949 138.941 1.00 68.93  ? 1230 SER A CA    1 
ATOM   3762 C  C     . SER A 1 885  ? 145.658 137.636 138.313 1.00 73.05  ? 1230 SER A C     1 
ATOM   3763 O  O     . SER A 1 885  ? 145.349 136.494 137.966 1.00 78.79  ? 1230 SER A O     1 
ATOM   3764 C  CB    . SER A 1 885  ? 147.946 138.547 137.890 1.00 65.19  ? 1230 SER A CB    1 
ATOM   3765 O  OG    . SER A 1 885  ? 147.459 139.793 137.428 1.00 70.91  ? 1230 SER A OG    1 
ATOM   3766 N  N     . GLY A 1 886  ? 144.836 138.677 138.188 1.00 74.78  ? 1231 GLY A N     1 
ATOM   3767 C  CA    . GLY A 1 886  ? 143.564 138.563 137.501 1.00 70.67  ? 1231 GLY A CA    1 
ATOM   3768 C  C     . GLY A 1 886  ? 143.643 138.670 135.996 1.00 80.28  ? 1231 GLY A C     1 
ATOM   3769 O  O     . GLY A 1 886  ? 142.672 138.338 135.310 1.00 88.97  ? 1231 GLY A O     1 
ATOM   3770 N  N     . MET A 1 887  ? 144.778 139.123 135.466 1.00 72.30  ? 1232 MET A N     1 
ATOM   3771 C  CA    . MET A 1 887  ? 145.013 139.163 134.030 1.00 64.99  ? 1232 MET A CA    1 
ATOM   3772 C  C     . MET A 1 887  ? 145.306 137.789 133.451 1.00 66.88  ? 1232 MET A C     1 
ATOM   3773 O  O     . MET A 1 887  ? 145.548 137.680 132.247 1.00 72.23  ? 1232 MET A O     1 
ATOM   3774 C  CB    . MET A 1 887  ? 146.178 140.103 133.715 1.00 68.71  ? 1232 MET A CB    1 
ATOM   3775 C  CG    . MET A 1 887  ? 145.805 141.566 133.627 1.00 66.71  ? 1232 MET A CG    1 
ATOM   3776 S  SD    . MET A 1 887  ? 147.258 142.630 133.622 1.00 74.38  ? 1232 MET A SD    1 
ATOM   3777 C  CE    . MET A 1 887  ? 148.144 141.984 132.217 1.00 72.18  ? 1232 MET A CE    1 
ATOM   3778 N  N     . ASN A 1 888  ? 145.292 136.750 134.273 1.00 79.05  ? 1233 ASN A N     1 
ATOM   3779 C  CA    . ASN A 1 888  ? 145.709 135.409 133.886 1.00 84.12  ? 1233 ASN A CA    1 
ATOM   3780 C  C     . ASN A 1 888  ? 144.461 134.538 133.798 1.00 83.61  ? 1233 ASN A C     1 
ATOM   3781 O  O     . ASN A 1 888  ? 143.863 134.200 134.824 1.00 82.33  ? 1233 ASN A O     1 
ATOM   3782 C  CB    . ASN A 1 888  ? 146.720 134.878 134.903 1.00 81.04  ? 1233 ASN A CB    1 
ATOM   3783 C  CG    . ASN A 1 888  ? 147.078 133.427 134.691 1.00 84.37  ? 1233 ASN A CG    1 
ATOM   3784 O  OD1   . ASN A 1 888  ? 146.214 132.560 134.635 1.00 89.07  ? 1233 ASN A OD1   1 
ATOM   3785 N  ND2   . ASN A 1 888  ? 148.370 133.154 134.592 1.00 87.22  ? 1233 ASN A ND2   1 
ATOM   3786 N  N     . ARG A 1 889  ? 144.070 134.173 132.574 1.00 76.82  ? 1234 ARG A N     1 
ATOM   3787 C  CA    . ARG A 1 889  ? 142.866 133.373 132.386 1.00 75.62  ? 1234 ARG A CA    1 
ATOM   3788 C  C     . ARG A 1 889  ? 143.101 131.884 132.581 1.00 79.40  ? 1234 ARG A C     1 
ATOM   3789 O  O     . ARG A 1 889  ? 142.131 131.133 132.723 1.00 78.98  ? 1234 ARG A O     1 
ATOM   3790 C  CB    . ARG A 1 889  ? 142.280 133.595 130.991 1.00 77.95  ? 1234 ARG A CB    1 
ATOM   3791 C  CG    . ARG A 1 889  ? 142.654 134.908 130.352 1.00 81.74  ? 1234 ARG A CG    1 
ATOM   3792 C  CD    . ARG A 1 889  ? 141.854 135.141 129.082 1.00 81.49  ? 1234 ARG A CD    1 
ATOM   3793 N  NE    . ARG A 1 889  ? 142.403 134.421 127.941 1.00 73.06  ? 1234 ARG A NE    1 
ATOM   3794 C  CZ    . ARG A 1 889  ? 141.873 133.321 127.427 1.00 75.68  ? 1234 ARG A CZ    1 
ATOM   3795 N  NH1   . ARG A 1 889  ? 140.781 132.778 127.937 1.00 79.41  ? 1234 ARG A NH1   1 
ATOM   3796 N  NH2   . ARG A 1 889  ? 142.451 132.754 126.372 1.00 77.47  ? 1234 ARG A NH2   1 
ATOM   3797 N  N     . PHE A 1 890  ? 144.353 131.437 132.583 1.00 80.12  ? 1235 PHE A N     1 
ATOM   3798 C  CA    . PHE A 1 890  ? 144.679 130.023 132.745 1.00 79.10  ? 1235 PHE A CA    1 
ATOM   3799 C  C     . PHE A 1 890  ? 145.438 129.865 134.058 1.00 82.26  ? 1235 PHE A C     1 
ATOM   3800 O  O     . PHE A 1 890  ? 146.668 129.832 134.091 1.00 85.57  ? 1235 PHE A O     1 
ATOM   3801 C  CB    . PHE A 1 890  ? 145.494 129.516 131.558 1.00 81.22  ? 1235 PHE A CB    1 
ATOM   3802 C  CG    . PHE A 1 890  ? 144.818 129.704 130.232 1.00 83.11  ? 1235 PHE A CG    1 
ATOM   3803 C  CD1   . PHE A 1 890  ? 143.533 129.240 130.024 1.00 81.25  ? 1235 PHE A CD1   1 
ATOM   3804 C  CD2   . PHE A 1 890  ? 145.471 130.338 129.191 1.00 82.10  ? 1235 PHE A CD2   1 
ATOM   3805 C  CE1   . PHE A 1 890  ? 142.910 129.408 128.804 1.00 78.51  ? 1235 PHE A CE1   1 
ATOM   3806 C  CE2   . PHE A 1 890  ? 144.853 130.508 127.970 1.00 79.44  ? 1235 PHE A CE2   1 
ATOM   3807 C  CZ    . PHE A 1 890  ? 143.572 130.042 127.776 1.00 79.58  ? 1235 PHE A CZ    1 
ATOM   3808 N  N     . ASN A 1 891  ? 144.687 129.762 135.153 1.00 86.08  ? 1236 ASN A N     1 
ATOM   3809 C  CA    . ASN A 1 891  ? 145.267 129.553 136.471 1.00 84.47  ? 1236 ASN A CA    1 
ATOM   3810 C  C     . ASN A 1 891  ? 145.049 128.141 136.987 1.00 86.71  ? 1236 ASN A C     1 
ATOM   3811 O  O     . ASN A 1 891  ? 145.545 127.806 138.067 1.00 89.42  ? 1236 ASN A O     1 
ATOM   3812 C  CB    . ASN A 1 891  ? 144.702 130.566 137.472 1.00 84.23  ? 1236 ASN A CB    1 
ATOM   3813 C  CG    . ASN A 1 891  ? 143.205 130.741 137.342 1.00 90.81  ? 1236 ASN A CG    1 
ATOM   3814 O  OD1   . ASN A 1 891  ? 142.516 129.888 136.784 1.00 92.39  ? 1236 ASN A OD1   1 
ATOM   3815 N  ND2   . ASN A 1 891  ? 142.692 131.851 137.860 1.00 88.25  ? 1236 ASN A ND2   1 
ATOM   3816 N  N     . SER A 1 892  ? 144.319 127.308 136.248 1.00 86.98  ? 1237 SER A N     1 
ATOM   3817 C  CA    . SER A 1 892  ? 144.142 125.904 136.585 1.00 85.69  ? 1237 SER A CA    1 
ATOM   3818 C  C     . SER A 1 892  ? 145.130 124.998 135.866 1.00 86.64  ? 1237 SER A C     1 
ATOM   3819 O  O     . SER A 1 892  ? 145.091 123.781 136.065 1.00 89.07  ? 1237 SER A O     1 
ATOM   3820 C  CB    . SER A 1 892  ? 142.710 125.462 136.266 1.00 85.79  ? 1237 SER A CB    1 
ATOM   3821 O  OG    . SER A 1 892  ? 142.536 125.266 134.874 1.00 88.83  ? 1237 SER A OG    1 
ATOM   3822 N  N     . ARG A 1 893  ? 146.004 125.556 135.035 1.00 81.36  ? 1238 ARG A N     1 
ATOM   3823 C  CA    . ARG A 1 893  ? 146.985 124.758 134.320 1.00 80.53  ? 1238 ARG A CA    1 
ATOM   3824 C  C     . ARG A 1 893  ? 148.218 124.527 135.189 1.00 85.37  ? 1238 ARG A C     1 
ATOM   3825 O  O     . ARG A 1 893  ? 148.419 125.174 136.219 1.00 89.98  ? 1238 ARG A O     1 
ATOM   3826 C  CB    . ARG A 1 893  ? 147.369 125.436 133.008 1.00 82.19  ? 1238 ARG A CB    1 
ATOM   3827 C  CG    . ARG A 1 893  ? 146.181 125.984 132.238 1.00 84.72  ? 1238 ARG A CG    1 
ATOM   3828 C  CD    . ARG A 1 893  ? 146.479 126.106 130.755 1.00 87.44  ? 1238 ARG A CD    1 
ATOM   3829 N  NE    . ARG A 1 893  ? 145.863 125.033 129.985 1.00 88.29  ? 1238 ARG A NE    1 
ATOM   3830 C  CZ    . ARG A 1 893  ? 144.582 124.994 129.645 1.00 87.60  ? 1238 ARG A CZ    1 
ATOM   3831 N  NH1   . ARG A 1 893  ? 143.742 125.950 130.003 1.00 84.79  ? 1238 ARG A NH1   1 
ATOM   3832 N  NH2   . ARG A 1 893  ? 144.133 123.968 128.928 1.00 88.01  ? 1238 ARG A NH2   1 
ATOM   3833 N  N     . THR A 1 894  ? 149.057 123.586 134.752 1.00 84.55  ? 1239 THR A N     1 
ATOM   3834 C  CA    . THR A 1 894  ? 150.226 123.209 135.541 1.00 84.62  ? 1239 THR A CA    1 
ATOM   3835 C  C     . THR A 1 894  ? 151.202 124.370 135.681 1.00 82.22  ? 1239 THR A C     1 
ATOM   3836 O  O     . THR A 1 894  ? 151.861 124.517 136.718 1.00 81.72  ? 1239 THR A O     1 
ATOM   3837 C  CB    . THR A 1 894  ? 150.919 122.005 134.907 1.00 86.60  ? 1239 THR A CB    1 
ATOM   3838 O  OG1   . THR A 1 894  ? 151.607 122.420 133.721 1.00 90.39  ? 1239 THR A OG1   1 
ATOM   3839 C  CG2   . THR A 1 894  ? 149.898 120.940 134.543 1.00 84.87  ? 1239 THR A CG2   1 
ATOM   3840 N  N     . TYR A 1 895  ? 151.314 125.201 134.643 1.00 80.70  ? 1240 TYR A N     1 
ATOM   3841 C  CA    . TYR A 1 895  ? 152.242 126.326 134.682 1.00 81.28  ? 1240 TYR A CA    1 
ATOM   3842 C  C     . TYR A 1 895  ? 151.885 127.288 135.808 1.00 85.16  ? 1240 TYR A C     1 
ATOM   3843 O  O     . TYR A 1 895  ? 152.749 127.696 136.594 1.00 86.52  ? 1240 TYR A O     1 
ATOM   3844 C  CB    . TYR A 1 895  ? 152.231 127.034 133.327 1.00 79.91  ? 1240 TYR A CB    1 
ATOM   3845 C  CG    . TYR A 1 895  ? 153.211 128.174 133.183 1.00 84.34  ? 1240 TYR A CG    1 
ATOM   3846 C  CD1   . TYR A 1 895  ? 154.509 127.944 132.747 1.00 84.72  ? 1240 TYR A CD1   1 
ATOM   3847 C  CD2   . TYR A 1 895  ? 152.834 129.480 133.453 1.00 85.65  ? 1240 TYR A CD2   1 
ATOM   3848 C  CE1   . TYR A 1 895  ? 155.407 128.981 132.601 1.00 84.03  ? 1240 TYR A CE1   1 
ATOM   3849 C  CE2   . TYR A 1 895  ? 153.726 130.523 133.309 1.00 88.75  ? 1240 TYR A CE2   1 
ATOM   3850 C  CZ    . TYR A 1 895  ? 155.009 130.268 132.882 1.00 89.48  ? 1240 TYR A CZ    1 
ATOM   3851 O  OH    . TYR A 1 895  ? 155.901 131.306 132.739 1.00 88.74  ? 1240 TYR A OH    1 
ATOM   3852 N  N     . SER A 1 896  ? 150.602 127.636 135.925 1.00 83.95  ? 1241 SER A N     1 
ATOM   3853 C  CA    . SER A 1 896  ? 150.175 128.554 136.976 1.00 78.37  ? 1241 SER A CA    1 
ATOM   3854 C  C     . SER A 1 896  ? 150.334 127.934 138.359 1.00 81.75  ? 1241 SER A C     1 
ATOM   3855 O  O     . SER A 1 896  ? 150.699 128.626 139.316 1.00 84.64  ? 1241 SER A O     1 
ATOM   3856 C  CB    . SER A 1 896  ? 148.729 128.980 136.743 1.00 74.91  ? 1241 SER A CB    1 
ATOM   3857 O  OG    . SER A 1 896  ? 148.523 129.377 135.399 1.00 79.29  ? 1241 SER A OG    1 
ATOM   3858 N  N     . LYS A 1 897  ? 150.051 126.637 138.492 1.00 73.28  ? 1242 LYS A N     1 
ATOM   3859 C  CA    . LYS A 1 897  ? 150.211 125.985 139.788 1.00 71.72  ? 1242 LYS A CA    1 
ATOM   3860 C  C     . LYS A 1 897  ? 151.671 125.971 140.223 1.00 74.23  ? 1242 LYS A C     1 
ATOM   3861 O  O     . LYS A 1 897  ? 151.984 126.243 141.388 1.00 79.30  ? 1242 LYS A O     1 
ATOM   3862 C  CB    . LYS A 1 897  ? 149.650 124.566 139.733 1.00 77.87  ? 1242 LYS A CB    1 
ATOM   3863 C  CG    . LYS A 1 897  ? 148.141 124.506 139.587 1.00 73.43  ? 1242 LYS A CG    1 
ATOM   3864 C  CD    . LYS A 1 897  ? 147.459 125.450 140.558 1.00 73.95  ? 1242 LYS A CD    1 
ATOM   3865 C  CE    . LYS A 1 897  ? 145.954 125.430 140.379 1.00 77.74  ? 1242 LYS A CE    1 
ATOM   3866 N  NZ    . LYS A 1 897  ? 145.496 124.167 139.740 1.00 78.48  ? 1242 LYS A NZ    1 
ATOM   3867 N  N     . PHE A 1 898  ? 152.584 125.661 139.301 1.00 77.71  ? 1243 PHE A N     1 
ATOM   3868 C  CA    . PHE A 1 898  ? 153.998 125.680 139.652 1.00 78.89  ? 1243 PHE A CA    1 
ATOM   3869 C  C     . PHE A 1 898  ? 154.494 127.100 139.885 1.00 79.67  ? 1243 PHE A C     1 
ATOM   3870 O  O     . PHE A 1 898  ? 155.488 127.300 140.591 1.00 80.04  ? 1243 PHE A O     1 
ATOM   3871 C  CB    . PHE A 1 898  ? 154.820 124.991 138.567 1.00 82.95  ? 1243 PHE A CB    1 
ATOM   3872 C  CG    . PHE A 1 898  ? 154.914 123.505 138.742 1.00 86.74  ? 1243 PHE A CG    1 
ATOM   3873 C  CD1   . PHE A 1 898  ? 153.888 122.679 138.315 1.00 84.13  ? 1243 PHE A CD1   1 
ATOM   3874 C  CD2   . PHE A 1 898  ? 156.011 122.936 139.362 1.00 86.79  ? 1243 PHE A CD2   1 
ATOM   3875 C  CE1   . PHE A 1 898  ? 153.965 121.314 138.486 1.00 81.46  ? 1243 PHE A CE1   1 
ATOM   3876 C  CE2   . PHE A 1 898  ? 156.093 121.573 139.536 1.00 86.48  ? 1243 PHE A CE2   1 
ATOM   3877 C  CZ    . PHE A 1 898  ? 155.068 120.761 139.097 1.00 85.03  ? 1243 PHE A CZ    1 
ATOM   3878 N  N     . LYS A 1 899  ? 153.830 128.093 139.288 1.00 77.04  ? 1244 LYS A N     1 
ATOM   3879 C  CA    . LYS A 1 899  ? 154.138 129.484 139.602 1.00 73.29  ? 1244 LYS A CA    1 
ATOM   3880 C  C     . LYS A 1 899  ? 153.715 129.823 141.025 1.00 69.79  ? 1244 LYS A C     1 
ATOM   3881 O  O     . LYS A 1 899  ? 154.432 130.525 141.748 1.00 71.00  ? 1244 LYS A O     1 
ATOM   3882 C  CB    . LYS A 1 899  ? 153.427 130.402 138.613 1.00 72.98  ? 1244 LYS A CB    1 
ATOM   3883 C  CG    . LYS A 1 899  ? 154.090 130.522 137.267 1.00 70.09  ? 1244 LYS A CG    1 
ATOM   3884 C  CD    . LYS A 1 899  ? 155.484 131.111 137.341 1.00 68.99  ? 1244 LYS A CD    1 
ATOM   3885 C  CE    . LYS A 1 899  ? 156.073 131.115 135.947 1.00 74.86  ? 1244 LYS A CE    1 
ATOM   3886 N  NZ    . LYS A 1 899  ? 157.439 131.673 135.858 1.00 76.43  ? 1244 LYS A NZ    1 
ATOM   3887 N  N     . ASN A 1 900  ? 152.542 129.334 141.432 1.00 65.60  ? 1245 ASN A N     1 
ATOM   3888 C  CA    . ASN A 1 900  ? 152.037 129.597 142.775 1.00 65.18  ? 1245 ASN A CA    1 
ATOM   3889 C  C     . ASN A 1 900  ? 152.853 128.865 143.831 1.00 70.93  ? 1245 ASN A C     1 
ATOM   3890 O  O     . ASN A 1 900  ? 152.971 129.344 144.964 1.00 72.68  ? 1245 ASN A O     1 
ATOM   3891 C  CB    . ASN A 1 900  ? 150.568 129.181 142.881 1.00 59.67  ? 1245 ASN A CB    1 
ATOM   3892 C  CG    . ASN A 1 900  ? 149.665 129.979 141.966 1.00 62.57  ? 1245 ASN A CG    1 
ATOM   3893 O  OD1   . ASN A 1 900  ? 150.131 130.781 141.162 1.00 66.91  ? 1245 ASN A OD1   1 
ATOM   3894 N  ND2   . ASN A 1 900  ? 148.361 129.767 142.090 1.00 62.11  ? 1245 ASN A ND2   1 
ATOM   3895 N  N     . SER A 1 901  ? 153.419 127.708 143.482 1.00 74.14  ? 1246 SER A N     1 
ATOM   3896 C  CA    . SER A 1 901  ? 154.093 126.878 144.475 1.00 67.90  ? 1246 SER A CA    1 
ATOM   3897 C  C     . SER A 1 901  ? 155.380 127.493 145.011 1.00 65.60  ? 1246 SER A C     1 
ATOM   3898 O  O     . SER A 1 901  ? 155.920 126.973 145.991 1.00 74.89  ? 1246 SER A O     1 
ATOM   3899 C  CB    . SER A 1 901  ? 154.401 125.497 143.896 1.00 66.88  ? 1246 SER A CB    1 
ATOM   3900 O  OG    . SER A 1 901  ? 155.750 125.416 143.472 1.00 69.60  ? 1246 SER A OG    1 
ATOM   3901 N  N     . LEU A 1 902  ? 155.895 128.566 144.405 1.00 49.70  ? 1247 LEU A N     1 
ATOM   3902 C  CA    . LEU A 1 902  ? 157.132 129.162 144.902 1.00 51.89  ? 1247 LEU A CA    1 
ATOM   3903 C  C     . LEU A 1 902  ? 156.939 129.918 146.211 1.00 62.35  ? 1247 LEU A C     1 
ATOM   3904 O  O     . LEU A 1 902  ? 157.928 130.218 146.891 1.00 69.29  ? 1247 LEU A O     1 
ATOM   3905 C  CB    . LEU A 1 902  ? 157.738 130.088 143.851 1.00 53.55  ? 1247 LEU A CB    1 
ATOM   3906 C  CG    . LEU A 1 902  ? 158.400 129.370 142.677 1.00 63.67  ? 1247 LEU A CG    1 
ATOM   3907 C  CD1   . LEU A 1 902  ? 159.173 130.349 141.835 1.00 62.87  ? 1247 LEU A CD1   1 
ATOM   3908 C  CD2   . LEU A 1 902  ? 159.313 128.267 143.177 1.00 64.27  ? 1247 LEU A CD2   1 
ATOM   3909 N  N     . VAL A 1 903  ? 155.698 130.234 146.583 1.00 61.41  ? 1248 VAL A N     1 
ATOM   3910 C  CA    . VAL A 1 903  ? 155.448 130.788 147.911 1.00 52.57  ? 1248 VAL A CA    1 
ATOM   3911 C  C     . VAL A 1 903  ? 155.890 129.796 148.977 1.00 56.54  ? 1248 VAL A C     1 
ATOM   3912 O  O     . VAL A 1 903  ? 156.440 130.175 150.019 1.00 64.01  ? 1248 VAL A O     1 
ATOM   3913 C  CB    . VAL A 1 903  ? 153.962 131.164 148.059 1.00 50.52  ? 1248 VAL A CB    1 
ATOM   3914 C  CG1   . VAL A 1 903  ? 153.617 131.437 149.509 1.00 55.68  ? 1248 VAL A CG1   1 
ATOM   3915 C  CG2   . VAL A 1 903  ? 153.635 132.366 147.199 1.00 55.59  ? 1248 VAL A CG2   1 
ATOM   3916 N  N     . VAL A 1 904  ? 155.677 128.505 148.720 1.00 48.44  ? 1249 VAL A N     1 
ATOM   3917 C  CA    . VAL A 1 904  ? 156.087 127.478 149.666 1.00 48.69  ? 1249 VAL A CA    1 
ATOM   3918 C  C     . VAL A 1 904  ? 157.606 127.426 149.778 1.00 52.54  ? 1249 VAL A C     1 
ATOM   3919 O  O     . VAL A 1 904  ? 158.152 127.249 150.871 1.00 66.52  ? 1249 VAL A O     1 
ATOM   3920 C  CB    . VAL A 1 904  ? 155.495 126.120 149.257 1.00 51.89  ? 1249 VAL A CB    1 
ATOM   3921 C  CG1   . VAL A 1 904  ? 155.498 125.177 150.432 1.00 57.05  ? 1249 VAL A CG1   1 
ATOM   3922 C  CG2   . VAL A 1 904  ? 154.085 126.306 148.735 1.00 54.26  ? 1249 VAL A CG2   1 
ATOM   3923 N  N     . SER A 1 905  ? 158.314 127.586 148.658 1.00 46.11  ? 1250 SER A N     1 
ATOM   3924 C  CA    . SER A 1 905  ? 159.773 127.633 148.712 1.00 46.41  ? 1250 SER A CA    1 
ATOM   3925 C  C     . SER A 1 905  ? 160.258 128.848 149.492 1.00 51.20  ? 1250 SER A C     1 
ATOM   3926 O  O     . SER A 1 905  ? 161.214 128.758 150.274 1.00 62.08  ? 1250 SER A O     1 
ATOM   3927 C  CB    . SER A 1 905  ? 160.354 127.643 147.300 1.00 52.59  ? 1250 SER A CB    1 
ATOM   3928 O  OG    . SER A 1 905  ? 160.169 126.396 146.660 1.00 60.13  ? 1250 SER A OG    1 
ATOM   3929 N  N     . PHE A 1 906  ? 159.618 129.998 149.283 1.00 46.00  ? 1251 PHE A N     1 
ATOM   3930 C  CA    . PHE A 1 906  ? 159.987 131.188 150.042 1.00 44.55  ? 1251 PHE A CA    1 
ATOM   3931 C  C     . PHE A 1 906  ? 159.781 130.971 151.535 1.00 49.79  ? 1251 PHE A C     1 
ATOM   3932 O  O     . PHE A 1 906  ? 160.641 131.328 152.351 1.00 56.67  ? 1251 PHE A O     1 
ATOM   3933 C  CB    . PHE A 1 906  ? 159.176 132.385 149.556 1.00 46.71  ? 1251 PHE A CB    1 
ATOM   3934 C  CG    . PHE A 1 906  ? 159.794 133.703 149.886 1.00 42.35  ? 1251 PHE A CG    1 
ATOM   3935 C  CD1   . PHE A 1 906  ? 161.151 133.805 150.106 1.00 47.83  ? 1251 PHE A CD1   1 
ATOM   3936 C  CD2   . PHE A 1 906  ? 159.020 134.840 149.970 1.00 52.28  ? 1251 PHE A CD2   1 
ATOM   3937 C  CE1   . PHE A 1 906  ? 161.722 135.017 150.407 1.00 54.11  ? 1251 PHE A CE1   1 
ATOM   3938 C  CE2   . PHE A 1 906  ? 159.587 136.054 150.271 1.00 51.63  ? 1251 PHE A CE2   1 
ATOM   3939 C  CZ    . PHE A 1 906  ? 160.940 136.144 150.489 1.00 54.12  ? 1251 PHE A CZ    1 
ATOM   3940 N  N     . LEU A 1 907  ? 158.649 130.375 151.911 1.00 49.37  ? 1252 LEU A N     1 
ATOM   3941 C  CA    . LEU A 1 907  ? 158.413 130.075 153.317 1.00 47.51  ? 1252 LEU A CA    1 
ATOM   3942 C  C     . LEU A 1 907  ? 159.418 129.060 153.842 1.00 48.28  ? 1252 LEU A C     1 
ATOM   3943 O  O     . LEU A 1 907  ? 159.770 129.094 155.024 1.00 59.28  ? 1252 LEU A O     1 
ATOM   3944 C  CB    . LEU A 1 907  ? 156.986 129.571 153.514 1.00 45.82  ? 1252 LEU A CB    1 
ATOM   3945 C  CG    . LEU A 1 907  ? 155.903 130.627 153.308 1.00 43.22  ? 1252 LEU A CG    1 
ATOM   3946 C  CD1   . LEU A 1 907  ? 154.597 130.162 153.903 1.00 46.30  ? 1252 LEU A CD1   1 
ATOM   3947 C  CD2   . LEU A 1 907  ? 156.320 131.951 153.913 1.00 45.29  ? 1252 LEU A CD2   1 
ATOM   3948 N  N     . SER A 1 908  ? 159.892 128.156 152.983 1.00 46.06  ? 1253 SER A N     1 
ATOM   3949 C  CA    . SER A 1 908  ? 160.928 127.215 153.393 1.00 43.14  ? 1253 SER A CA    1 
ATOM   3950 C  C     . SER A 1 908  ? 162.236 127.929 153.709 1.00 49.98  ? 1253 SER A C     1 
ATOM   3951 O  O     . SER A 1 908  ? 162.896 127.610 154.703 1.00 55.52  ? 1253 SER A O     1 
ATOM   3952 C  CB    . SER A 1 908  ? 161.139 126.166 152.308 1.00 44.14  ? 1253 SER A CB    1 
ATOM   3953 O  OG    . SER A 1 908  ? 159.902 125.621 151.893 1.00 59.10  ? 1253 SER A OG    1 
ATOM   3954 N  N     . TYR A 1 909  ? 162.633 128.893 152.873 1.00 53.13  ? 1254 TYR A N     1 
ATOM   3955 C  CA    . TYR A 1 909  ? 163.803 129.703 153.218 1.00 40.52  ? 1254 TYR A CA    1 
ATOM   3956 C  C     . TYR A 1 909  ? 163.592 130.457 154.522 1.00 47.04  ? 1254 TYR A C     1 
ATOM   3957 O  O     . TYR A 1 909  ? 164.502 130.529 155.357 1.00 59.77  ? 1254 TYR A O     1 
ATOM   3958 C  CB    . TYR A 1 909  ? 164.166 130.688 152.108 1.00 44.12  ? 1254 TYR A CB    1 
ATOM   3959 C  CG    . TYR A 1 909  ? 164.775 130.082 150.866 1.00 49.07  ? 1254 TYR A CG    1 
ATOM   3960 C  CD1   . TYR A 1 909  ? 166.149 130.089 150.688 1.00 45.56  ? 1254 TYR A CD1   1 
ATOM   3961 C  CD2   . TYR A 1 909  ? 163.991 129.549 149.860 1.00 51.73  ? 1254 TYR A CD2   1 
ATOM   3962 C  CE1   . TYR A 1 909  ? 166.726 129.558 149.565 1.00 43.98  ? 1254 TYR A CE1   1 
ATOM   3963 C  CE2   . TYR A 1 909  ? 164.561 129.010 148.727 1.00 50.20  ? 1254 TYR A CE2   1 
ATOM   3964 C  CZ    . TYR A 1 909  ? 165.929 129.019 148.586 1.00 50.45  ? 1254 TYR A CZ    1 
ATOM   3965 O  OH    . TYR A 1 909  ? 166.510 128.490 147.462 1.00 57.81  ? 1254 TYR A OH    1 
ATOM   3966 N  N     . CYS A 1 910  ? 162.403 131.032 154.712 1.00 41.48  ? 1255 CYS A N     1 
ATOM   3967 C  CA    . CYS A 1 910  ? 162.139 131.762 155.949 1.00 41.99  ? 1255 CYS A CA    1 
ATOM   3968 C  C     . CYS A 1 910  ? 162.253 130.853 157.165 1.00 47.49  ? 1255 CYS A C     1 
ATOM   3969 O  O     . CYS A 1 910  ? 162.838 131.236 158.184 1.00 47.37  ? 1255 CYS A O     1 
ATOM   3970 C  CB    . CYS A 1 910  ? 160.757 132.408 155.900 1.00 52.20  ? 1255 CYS A CB    1 
ATOM   3971 S  SG    . CYS A 1 910  ? 160.509 133.673 157.162 1.00 66.04  ? 1255 CYS A SG    1 
ATOM   3972 N  N     . ASP A 1 911  ? 161.698 129.645 157.075 1.00 51.68  ? 1256 ASP A N     1 
ATOM   3973 C  CA    . ASP A 1 911  ? 161.749 128.712 158.194 1.00 41.74  ? 1256 ASP A CA    1 
ATOM   3974 C  C     . ASP A 1 911  ? 163.166 128.223 158.458 1.00 50.44  ? 1256 ASP A C     1 
ATOM   3975 O  O     . ASP A 1 911  ? 163.580 128.109 159.616 1.00 64.70  ? 1256 ASP A O     1 
ATOM   3976 C  CB    . ASP A 1 911  ? 160.819 127.533 157.931 1.00 44.15  ? 1256 ASP A CB    1 
ATOM   3977 C  CG    . ASP A 1 911  ? 161.112 126.359 158.827 1.00 55.62  ? 1256 ASP A CG    1 
ATOM   3978 O  OD1   . ASP A 1 911  ? 161.109 126.540 160.060 1.00 53.88  ? 1256 ASP A OD1   1 
ATOM   3979 O  OD2   . ASP A 1 911  ? 161.348 125.255 158.299 1.00 64.07  ? 1256 ASP A OD2   1 
ATOM   3980 N  N     . TYR A 1 912  ? 163.922 127.920 157.404 1.00 44.04  ? 1257 TYR A N     1 
ATOM   3981 C  CA    . TYR A 1 912  ? 165.265 127.389 157.601 1.00 47.01  ? 1257 TYR A CA    1 
ATOM   3982 C  C     . TYR A 1 912  ? 166.201 128.446 158.172 1.00 52.23  ? 1257 TYR A C     1 
ATOM   3983 O  O     . TYR A 1 912  ? 166.939 128.184 159.128 1.00 48.63  ? 1257 TYR A O     1 
ATOM   3984 C  CB    . TYR A 1 912  ? 165.808 126.836 156.284 1.00 45.24  ? 1257 TYR A CB    1 
ATOM   3985 C  CG    . TYR A 1 912  ? 167.147 126.160 156.428 1.00 44.68  ? 1257 TYR A CG    1 
ATOM   3986 C  CD1   . TYR A 1 912  ? 167.236 124.828 156.789 1.00 50.32  ? 1257 TYR A CD1   1 
ATOM   3987 C  CD2   . TYR A 1 912  ? 168.323 126.858 156.210 1.00 48.17  ? 1257 TYR A CD2   1 
ATOM   3988 C  CE1   . TYR A 1 912  ? 168.457 124.210 156.927 1.00 52.70  ? 1257 TYR A CE1   1 
ATOM   3989 C  CE2   . TYR A 1 912  ? 169.547 126.249 156.344 1.00 50.35  ? 1257 TYR A CE2   1 
ATOM   3990 C  CZ    . TYR A 1 912  ? 169.609 124.926 156.703 1.00 53.94  ? 1257 TYR A CZ    1 
ATOM   3991 O  OH    . TYR A 1 912  ? 170.833 124.315 156.838 1.00 60.52  ? 1257 TYR A OH    1 
ATOM   3992 N  N     . TYR A 1 913  ? 166.183 129.654 157.605 1.00 47.46  ? 1258 TYR A N     1 
ATOM   3993 C  CA    . TYR A 1 913  ? 167.164 130.656 158.006 1.00 38.21  ? 1258 TYR A CA    1 
ATOM   3994 C  C     . TYR A 1 913  ? 166.762 131.399 159.273 1.00 42.51  ? 1258 TYR A C     1 
ATOM   3995 O  O     . TYR A 1 913  ? 167.638 131.839 160.024 1.00 48.67  ? 1258 TYR A O     1 
ATOM   3996 C  CB    . TYR A 1 913  ? 167.386 131.649 156.870 1.00 33.32  ? 1258 TYR A CB    1 
ATOM   3997 C  CG    . TYR A 1 913  ? 168.269 131.120 155.769 1.00 35.61  ? 1258 TYR A CG    1 
ATOM   3998 C  CD1   . TYR A 1 913  ? 169.648 131.217 155.855 1.00 40.61  ? 1258 TYR A CD1   1 
ATOM   3999 C  CD2   . TYR A 1 913  ? 167.724 130.524 154.643 1.00 39.16  ? 1258 TYR A CD2   1 
ATOM   4000 C  CE1   . TYR A 1 913  ? 170.456 130.736 154.852 1.00 36.60  ? 1258 TYR A CE1   1 
ATOM   4001 C  CE2   . TYR A 1 913  ? 168.526 130.041 153.636 1.00 36.25  ? 1258 TYR A CE2   1 
ATOM   4002 C  CZ    . TYR A 1 913  ? 169.891 130.150 153.746 1.00 34.03  ? 1258 TYR A CZ    1 
ATOM   4003 O  OH    . TYR A 1 913  ? 170.696 129.670 152.743 1.00 48.78  ? 1258 TYR A OH    1 
ATOM   4004 N  N     . ARG A 1 914  ? 165.465 131.544 159.525 1.00 45.15  ? 1259 ARG A N     1 
ATOM   4005 C  CA    . ARG A 1 914  ? 164.952 132.325 160.645 1.00 44.61  ? 1259 ARG A CA    1 
ATOM   4006 C  C     . ARG A 1 914  ? 165.564 133.729 160.694 1.00 44.93  ? 1259 ARG A C     1 
ATOM   4007 O  O     . ARG A 1 914  ? 166.268 134.072 161.647 1.00 48.36  ? 1259 ARG A O     1 
ATOM   4008 C  CB    . ARG A 1 914  ? 165.177 131.597 161.963 1.00 46.83  ? 1259 ARG A CB    1 
ATOM   4009 C  CG    . ARG A 1 914  ? 164.466 130.263 162.071 1.00 51.41  ? 1259 ARG A CG    1 
ATOM   4010 C  CD    . ARG A 1 914  ? 162.992 130.442 162.364 1.00 50.88  ? 1259 ARG A CD    1 
ATOM   4011 N  NE    . ARG A 1 914  ? 162.259 129.187 162.252 1.00 55.05  ? 1259 ARG A NE    1 
ATOM   4012 C  CZ    . ARG A 1 914  ? 161.929 128.418 163.280 1.00 52.90  ? 1259 ARG A CZ    1 
ATOM   4013 N  NH1   . ARG A 1 914  ? 162.254 128.744 164.519 1.00 54.45  ? 1259 ARG A NH1   1 
ATOM   4014 N  NH2   . ARG A 1 914  ? 161.253 127.295 163.059 1.00 55.56  ? 1259 ARG A NH2   1 
ATOM   4015 N  N     . PRO A 1 915  ? 165.318 134.559 159.684 1.00 34.88  ? 1260 PRO A N     1 
ATOM   4016 C  CA    . PRO A 1 915  ? 165.851 135.922 159.710 1.00 38.86  ? 1260 PRO A CA    1 
ATOM   4017 C  C     . PRO A 1 915  ? 165.095 136.792 160.700 1.00 46.13  ? 1260 PRO A C     1 
ATOM   4018 O  O     . PRO A 1 915  ? 164.004 136.455 161.163 1.00 57.80  ? 1260 PRO A O     1 
ATOM   4019 C  CB    . PRO A 1 915  ? 165.639 136.404 158.276 1.00 45.97  ? 1260 PRO A CB    1 
ATOM   4020 C  CG    . PRO A 1 915  ? 164.430 135.671 157.841 1.00 43.40  ? 1260 PRO A CG    1 
ATOM   4021 C  CD    . PRO A 1 915  ? 164.514 134.317 158.474 1.00 38.90  ? 1260 PRO A CD    1 
ATOM   4022 N  N     . ARG A 1 916  ? 165.702 137.933 161.031 1.00 46.46  ? 1261 ARG A N     1 
ATOM   4023 C  CA    . ARG A 1 916  ? 165.056 138.859 161.954 1.00 36.40  ? 1261 ARG A CA    1 
ATOM   4024 C  C     . ARG A 1 916  ? 163.761 139.407 161.373 1.00 38.63  ? 1261 ARG A C     1 
ATOM   4025 O  O     . ARG A 1 916  ? 162.745 139.483 162.073 1.00 47.51  ? 1261 ARG A O     1 
ATOM   4026 C  CB    . ARG A 1 916  ? 166.008 139.998 162.312 1.00 41.31  ? 1261 ARG A CB    1 
ATOM   4027 C  CG    . ARG A 1 916  ? 167.070 139.619 163.326 1.00 47.02  ? 1261 ARG A CG    1 
ATOM   4028 C  CD    . ARG A 1 916  ? 168.009 140.778 163.585 1.00 44.46  ? 1261 ARG A CD    1 
ATOM   4029 N  NE    . ARG A 1 916  ? 167.301 141.937 164.113 1.00 44.64  ? 1261 ARG A NE    1 
ATOM   4030 C  CZ    . ARG A 1 916  ? 167.832 143.144 164.239 1.00 48.87  ? 1261 ARG A CZ    1 
ATOM   4031 N  NH1   . ARG A 1 916  ? 169.076 143.393 163.867 1.00 50.07  ? 1261 ARG A NH1   1 
ATOM   4032 N  NH2   . ARG A 1 916  ? 167.096 144.126 164.749 1.00 49.77  ? 1261 ARG A NH2   1 
ATOM   4033 N  N     . PHE A 1 917  ? 163.769 139.785 160.097 1.00 33.45  ? 1262 PHE A N     1 
ATOM   4034 C  CA    . PHE A 1 917  ? 162.588 140.316 159.432 1.00 31.88  ? 1262 PHE A CA    1 
ATOM   4035 C  C     . PHE A 1 917  ? 162.372 139.586 158.114 1.00 37.72  ? 1262 PHE A C     1 
ATOM   4036 O  O     . PHE A 1 917  ? 163.333 139.217 157.431 1.00 54.94  ? 1262 PHE A O     1 
ATOM   4037 C  CB    . PHE A 1 917  ? 162.711 141.820 159.166 1.00 34.21  ? 1262 PHE A CB    1 
ATOM   4038 C  CG    . PHE A 1 917  ? 162.820 142.662 160.405 1.00 35.64  ? 1262 PHE A CG    1 
ATOM   4039 C  CD1   . PHE A 1 917  ? 161.689 143.041 161.102 1.00 48.70  ? 1262 PHE A CD1   1 
ATOM   4040 C  CD2   . PHE A 1 917  ? 164.050 143.096 160.855 1.00 31.87  ? 1262 PHE A CD2   1 
ATOM   4041 C  CE1   . PHE A 1 917  ? 161.787 143.821 162.234 1.00 43.66  ? 1262 PHE A CE1   1 
ATOM   4042 C  CE2   . PHE A 1 917  ? 164.151 143.875 161.983 1.00 38.98  ? 1262 PHE A CE2   1 
ATOM   4043 C  CZ    . PHE A 1 917  ? 163.018 144.238 162.673 1.00 40.68  ? 1262 PHE A CZ    1 
ATOM   4044 N  N     . PHE A 1 918  ? 161.105 139.387 157.763 1.00 24.63  ? 1263 PHE A N     1 
ATOM   4045 C  CA    . PHE A 1 918  ? 160.716 138.655 156.566 1.00 26.56  ? 1263 PHE A CA    1 
ATOM   4046 C  C     . PHE A 1 918  ? 159.649 139.445 155.827 1.00 32.75  ? 1263 PHE A C     1 
ATOM   4047 O  O     . PHE A 1 918  ? 158.644 139.840 156.425 1.00 50.00  ? 1263 PHE A O     1 
ATOM   4048 C  CB    . PHE A 1 918  ? 160.198 137.263 156.934 1.00 32.54  ? 1263 PHE A CB    1 
ATOM   4049 C  CG    . PHE A 1 918  ? 159.380 136.609 155.859 1.00 43.04  ? 1263 PHE A CG    1 
ATOM   4050 C  CD1   . PHE A 1 918  ? 159.979 136.116 154.716 1.00 44.02  ? 1263 PHE A CD1   1 
ATOM   4051 C  CD2   . PHE A 1 918  ? 158.014 136.464 156.005 1.00 50.23  ? 1263 PHE A CD2   1 
ATOM   4052 C  CE1   . PHE A 1 918  ? 159.230 135.505 153.735 1.00 39.38  ? 1263 PHE A CE1   1 
ATOM   4053 C  CE2   . PHE A 1 918  ? 157.260 135.854 155.025 1.00 45.70  ? 1263 PHE A CE2   1 
ATOM   4054 C  CZ    . PHE A 1 918  ? 157.869 135.374 153.890 1.00 36.10  ? 1263 PHE A CZ    1 
ATOM   4055 N  N     . LEU A 1 919  ? 159.865 139.670 154.531 1.00 32.80  ? 1264 LEU A N     1 
ATOM   4056 C  CA    . LEU A 1 919  ? 158.959 140.480 153.723 1.00 33.89  ? 1264 LEU A CA    1 
ATOM   4057 C  C     . LEU A 1 919  ? 158.572 139.740 152.452 1.00 42.08  ? 1264 LEU A C     1 
ATOM   4058 O  O     . LEU A 1 919  ? 159.441 139.363 151.656 1.00 54.91  ? 1264 LEU A O     1 
ATOM   4059 C  CB    . LEU A 1 919  ? 159.590 141.825 153.359 1.00 40.24  ? 1264 LEU A CB    1 
ATOM   4060 C  CG    . LEU A 1 919  ? 158.620 142.862 152.793 1.00 41.88  ? 1264 LEU A CG    1 
ATOM   4061 C  CD1   . LEU A 1 919  ? 158.916 144.228 153.374 1.00 38.80  ? 1264 LEU A CD1   1 
ATOM   4062 C  CD2   . LEU A 1 919  ? 158.675 142.905 151.279 1.00 43.47  ? 1264 LEU A CD2   1 
ATOM   4063 N  N     . LEU A 1 920  ? 157.268 139.566 152.249 1.00 34.23  ? 1265 LEU A N     1 
ATOM   4064 C  CA    . LEU A 1 920  ? 156.733 138.892 151.071 1.00 32.63  ? 1265 LEU A CA    1 
ATOM   4065 C  C     . LEU A 1 920  ? 155.808 139.850 150.336 1.00 39.90  ? 1265 LEU A C     1 
ATOM   4066 O  O     . LEU A 1 920  ? 154.798 140.290 150.892 1.00 51.21  ? 1265 LEU A O     1 
ATOM   4067 C  CB    . LEU A 1 920  ? 155.985 137.617 151.463 1.00 49.32  ? 1265 LEU A CB    1 
ATOM   4068 C  CG    . LEU A 1 920  ? 155.383 136.754 150.353 1.00 42.26  ? 1265 LEU A CG    1 
ATOM   4069 C  CD1   . LEU A 1 920  ? 155.583 135.284 150.664 1.00 40.79  ? 1265 LEU A CD1   1 
ATOM   4070 C  CD2   . LEU A 1 920  ? 153.907 137.053 150.180 1.00 50.60  ? 1265 LEU A CD2   1 
ATOM   4071 N  N     . GLU A 1 921  ? 156.139 140.157 149.088 1.00 62.43  ? 1266 GLU A N     1 
ATOM   4072 C  CA    . GLU A 1 921  ? 155.348 141.074 148.279 1.00 54.52  ? 1266 GLU A CA    1 
ATOM   4073 C  C     . GLU A 1 921  ? 154.689 140.316 147.135 1.00 62.77  ? 1266 GLU A C     1 
ATOM   4074 O  O     . GLU A 1 921  ? 155.273 139.380 146.585 1.00 67.46  ? 1266 GLU A O     1 
ATOM   4075 C  CB    . GLU A 1 921  ? 156.221 142.206 147.732 1.00 48.21  ? 1266 GLU A CB    1 
ATOM   4076 C  CG    . GLU A 1 921  ? 155.475 143.222 146.892 1.00 52.00  ? 1266 GLU A CG    1 
ATOM   4077 C  CD    . GLU A 1 921  ? 155.561 142.925 145.410 1.00 64.78  ? 1266 GLU A CD    1 
ATOM   4078 O  OE1   . GLU A 1 921  ? 156.376 142.063 145.021 1.00 60.92  ? 1266 GLU A OE1   1 
ATOM   4079 O  OE2   . GLU A 1 921  ? 154.813 143.551 144.633 1.00 73.94  ? 1266 GLU A OE2   1 
ATOM   4080 N  N     . ASN A 1 922  ? 153.470 140.711 146.783 1.00 52.53  ? 1267 ASN A N     1 
ATOM   4081 C  CA    . ASN A 1 922  ? 152.764 140.061 145.685 1.00 45.83  ? 1267 ASN A CA    1 
ATOM   4082 C  C     . ASN A 1 922  ? 151.699 141.012 145.159 1.00 51.71  ? 1267 ASN A C     1 
ATOM   4083 O  O     . ASN A 1 922  ? 151.529 142.123 145.663 1.00 52.28  ? 1267 ASN A O     1 
ATOM   4084 C  CB    . ASN A 1 922  ? 152.155 138.732 146.130 1.00 45.97  ? 1267 ASN A CB    1 
ATOM   4085 C  CG    . ASN A 1 922  ? 152.650 137.568 145.310 1.00 47.68  ? 1267 ASN A CG    1 
ATOM   4086 O  OD1   . ASN A 1 922  ? 153.094 137.740 144.179 1.00 49.59  ? 1267 ASN A OD1   1 
ATOM   4087 N  ND2   . ASN A 1 922  ? 152.577 136.371 145.876 1.00 57.39  ? 1267 ASN A ND2   1 
ATOM   4088 N  N     . VAL A 1 923  ? 150.971 140.563 144.138 1.00 49.74  ? 1268 VAL A N     1 
ATOM   4089 C  CA    . VAL A 1 923  ? 149.880 141.348 143.574 1.00 48.31  ? 1268 VAL A CA    1 
ATOM   4090 C  C     . VAL A 1 923  ? 148.752 141.412 144.593 1.00 52.33  ? 1268 VAL A C     1 
ATOM   4091 O  O     . VAL A 1 923  ? 148.752 140.668 145.578 1.00 57.82  ? 1268 VAL A O     1 
ATOM   4092 C  CB    . VAL A 1 923  ? 149.390 140.758 142.241 1.00 48.64  ? 1268 VAL A CB    1 
ATOM   4093 C  CG1   . VAL A 1 923  ? 150.358 141.096 141.132 1.00 47.41  ? 1268 VAL A CG1   1 
ATOM   4094 C  CG2   . VAL A 1 923  ? 149.219 139.263 142.358 1.00 49.74  ? 1268 VAL A CG2   1 
ATOM   4095 N  N     . ARG A 1 924  ? 147.789 142.308 144.375 1.00 50.16  ? 1269 ARG A N     1 
ATOM   4096 C  CA    . ARG A 1 924  ? 146.696 142.448 145.331 1.00 47.94  ? 1269 ARG A CA    1 
ATOM   4097 C  C     . ARG A 1 924  ? 145.868 141.173 145.412 1.00 51.49  ? 1269 ARG A C     1 
ATOM   4098 O  O     . ARG A 1 924  ? 145.503 140.730 146.507 1.00 60.79  ? 1269 ARG A O     1 
ATOM   4099 C  CB    . ARG A 1 924  ? 145.814 143.636 144.959 1.00 56.24  ? 1269 ARG A CB    1 
ATOM   4100 C  CG    . ARG A 1 924  ? 144.811 144.019 146.032 1.00 57.42  ? 1269 ARG A CG    1 
ATOM   4101 C  CD    . ARG A 1 924  ? 143.401 143.652 145.611 1.00 59.31  ? 1269 ARG A CD    1 
ATOM   4102 N  NE    . ARG A 1 924  ? 142.487 143.582 146.744 1.00 57.33  ? 1269 ARG A NE    1 
ATOM   4103 C  CZ    . ARG A 1 924  ? 141.566 142.641 146.900 1.00 60.48  ? 1269 ARG A CZ    1 
ATOM   4104 N  NH1   . ARG A 1 924  ? 141.420 141.666 146.019 1.00 59.54  ? 1269 ARG A NH1   1 
ATOM   4105 N  NH2   . ARG A 1 924  ? 140.773 142.680 147.966 1.00 62.01  ? 1269 ARG A NH2   1 
ATOM   4106 N  N     . ASN A 1 925  ? 145.588 140.551 144.266 1.00 51.32  ? 1270 ASN A N     1 
ATOM   4107 C  CA    . ASN A 1 925  ? 144.775 139.340 144.245 1.00 60.17  ? 1270 ASN A CA    1 
ATOM   4108 C  C     . ASN A 1 925  ? 145.368 138.216 145.084 1.00 66.51  ? 1270 ASN A C     1 
ATOM   4109 O  O     . ASN A 1 925  ? 144.679 137.219 145.326 1.00 69.52  ? 1270 ASN A O     1 
ATOM   4110 C  CB    . ASN A 1 925  ? 144.580 138.868 142.805 1.00 56.65  ? 1270 ASN A CB    1 
ATOM   4111 C  CG    . ASN A 1 925  ? 143.238 138.201 142.588 1.00 61.36  ? 1270 ASN A CG    1 
ATOM   4112 O  OD1   . ASN A 1 925  ? 142.194 138.769 142.902 1.00 65.30  ? 1270 ASN A OD1   1 
ATOM   4113 N  ND2   . ASN A 1 925  ? 143.258 136.993 142.041 1.00 58.63  ? 1270 ASN A ND2   1 
ATOM   4114 N  N     . PHE A 1 926  ? 146.616 138.352 145.535 1.00 51.68  ? 1271 PHE A N     1 
ATOM   4115 C  CA    . PHE A 1 926  ? 147.190 137.369 146.443 1.00 37.06  ? 1271 PHE A CA    1 
ATOM   4116 C  C     . PHE A 1 926  ? 146.362 137.234 147.711 1.00 47.60  ? 1271 PHE A C     1 
ATOM   4117 O  O     . PHE A 1 926  ? 146.246 136.134 148.260 1.00 55.02  ? 1271 PHE A O     1 
ATOM   4118 C  CB    . PHE A 1 926  ? 148.629 137.757 146.779 1.00 44.20  ? 1271 PHE A CB    1 
ATOM   4119 C  CG    . PHE A 1 926  ? 149.220 136.992 147.925 1.00 56.26  ? 1271 PHE A CG    1 
ATOM   4120 C  CD1   . PHE A 1 926  ? 149.397 135.624 147.847 1.00 60.06  ? 1271 PHE A CD1   1 
ATOM   4121 C  CD2   . PHE A 1 926  ? 149.617 137.647 149.074 1.00 53.77  ? 1271 PHE A CD2   1 
ATOM   4122 C  CE1   . PHE A 1 926  ? 149.949 134.923 148.897 1.00 44.85  ? 1271 PHE A CE1   1 
ATOM   4123 C  CE2   . PHE A 1 926  ? 150.168 136.950 150.125 1.00 52.15  ? 1271 PHE A CE2   1 
ATOM   4124 C  CZ    . PHE A 1 926  ? 150.334 135.587 150.036 1.00 47.99  ? 1271 PHE A CZ    1 
ATOM   4125 N  N     . VAL A 1 927  ? 145.763 138.333 148.185 1.00 56.73  ? 1272 VAL A N     1 
ATOM   4126 C  CA    . VAL A 1 927  ? 144.927 138.267 149.383 1.00 50.39  ? 1272 VAL A CA    1 
ATOM   4127 C  C     . VAL A 1 927  ? 143.528 137.755 149.095 1.00 53.30  ? 1272 VAL A C     1 
ATOM   4128 O  O     . VAL A 1 927  ? 142.698 137.711 150.011 1.00 57.63  ? 1272 VAL A O     1 
ATOM   4129 C  CB    . VAL A 1 927  ? 144.803 139.637 150.079 1.00 51.62  ? 1272 VAL A CB    1 
ATOM   4130 C  CG1   . VAL A 1 927  ? 146.171 140.236 150.322 1.00 55.73  ? 1272 VAL A CG1   1 
ATOM   4131 C  CG2   . VAL A 1 927  ? 143.946 140.574 149.253 1.00 52.13  ? 1272 VAL A CG2   1 
ATOM   4132 N  N     . SER A 1 928  ? 143.237 137.364 147.853 1.00 61.52  ? 1273 SER A N     1 
ATOM   4133 C  CA    . SER A 1 928  ? 141.908 136.869 147.520 1.00 60.65  ? 1273 SER A CA    1 
ATOM   4134 C  C     . SER A 1 928  ? 141.936 135.637 146.626 1.00 61.16  ? 1273 SER A C     1 
ATOM   4135 O  O     . SER A 1 928  ? 140.883 135.248 146.107 1.00 67.01  ? 1273 SER A O     1 
ATOM   4136 C  CB    . SER A 1 928  ? 141.080 137.962 146.844 1.00 65.04  ? 1273 SER A CB    1 
ATOM   4137 O  OG    . SER A 1 928  ? 139.747 137.527 146.649 1.00 75.54  ? 1273 SER A OG    1 
ATOM   4138 N  N     . PHE A 1 929  ? 143.093 135.015 146.423 1.00 64.42  ? 1274 PHE A N     1 
ATOM   4139 C  CA    . PHE A 1 929  ? 143.180 133.841 145.568 1.00 65.30  ? 1274 PHE A CA    1 
ATOM   4140 C  C     . PHE A 1 929  ? 142.605 132.631 146.289 1.00 65.75  ? 1274 PHE A C     1 
ATOM   4141 O  O     . PHE A 1 929  ? 143.015 132.316 147.410 1.00 73.94  ? 1274 PHE A O     1 
ATOM   4142 C  CB    . PHE A 1 929  ? 144.631 133.583 145.169 1.00 64.54  ? 1274 PHE A CB    1 
ATOM   4143 C  CG    . PHE A 1 929  ? 144.799 132.449 144.204 1.00 63.33  ? 1274 PHE A CG    1 
ATOM   4144 C  CD1   . PHE A 1 929  ? 144.363 132.564 142.899 1.00 66.52  ? 1274 PHE A CD1   1 
ATOM   4145 C  CD2   . PHE A 1 929  ? 145.394 131.267 144.603 1.00 64.61  ? 1274 PHE A CD2   1 
ATOM   4146 C  CE1   . PHE A 1 929  ? 144.518 131.521 142.010 1.00 72.47  ? 1274 PHE A CE1   1 
ATOM   4147 C  CE2   . PHE A 1 929  ? 145.551 130.222 143.718 1.00 66.93  ? 1274 PHE A CE2   1 
ATOM   4148 C  CZ    . PHE A 1 929  ? 145.112 130.349 142.421 1.00 67.78  ? 1274 PHE A CZ    1 
ATOM   4149 N  N     . LYS A 1 930  ? 141.657 131.956 145.643 1.00 60.91  ? 1275 LYS A N     1 
ATOM   4150 C  CA    . LYS A 1 930  ? 141.003 130.769 146.191 1.00 63.03  ? 1275 LYS A CA    1 
ATOM   4151 C  C     . LYS A 1 930  ? 140.407 131.057 147.568 1.00 64.91  ? 1275 LYS A C     1 
ATOM   4152 O  O     . LYS A 1 930  ? 140.685 130.374 148.553 1.00 68.16  ? 1275 LYS A O     1 
ATOM   4153 C  CB    . LYS A 1 930  ? 141.976 129.590 146.251 1.00 63.33  ? 1275 LYS A CB    1 
ATOM   4154 C  CG    . LYS A 1 930  ? 141.722 128.515 145.211 1.00 65.25  ? 1275 LYS A CG    1 
ATOM   4155 C  CD    . LYS A 1 930  ? 141.871 129.064 143.805 1.00 68.40  ? 1275 LYS A CD    1 
ATOM   4156 C  CE    . LYS A 1 930  ? 141.807 127.955 142.770 1.00 69.24  ? 1275 LYS A CE    1 
ATOM   4157 N  NZ    . LYS A 1 930  ? 141.964 128.484 141.388 1.00 66.89  ? 1275 LYS A NZ    1 
ATOM   4158 N  N     . ARG A 1 931  ? 139.564 132.090 147.615 1.00 68.32  ? 1276 ARG A N     1 
ATOM   4159 C  CA    . ARG A 1 931  ? 138.919 132.531 148.854 1.00 68.56  ? 1276 ARG A CA    1 
ATOM   4160 C  C     . ARG A 1 931  ? 139.948 132.831 149.942 1.00 70.76  ? 1276 ARG A C     1 
ATOM   4161 O  O     . ARG A 1 931  ? 139.762 132.486 151.110 1.00 73.15  ? 1276 ARG A O     1 
ATOM   4162 C  CB    . ARG A 1 931  ? 137.893 131.506 149.344 1.00 68.30  ? 1276 ARG A CB    1 
ATOM   4163 C  CG    . ARG A 1 931  ? 137.130 130.806 148.234 1.00 70.46  ? 1276 ARG A CG    1 
ATOM   4164 C  CD    . ARG A 1 931  ? 135.765 131.434 148.027 1.00 72.95  ? 1276 ARG A CD    1 
ATOM   4165 N  NE    . ARG A 1 931  ? 134.954 131.371 149.237 1.00 74.79  ? 1276 ARG A NE    1 
ATOM   4166 C  CZ    . ARG A 1 931  ? 134.297 130.294 149.644 1.00 76.40  ? 1276 ARG A CZ    1 
ATOM   4167 N  NH1   . ARG A 1 931  ? 134.330 129.164 148.957 1.00 72.39  ? 1276 ARG A NH1   1 
ATOM   4168 N  NH2   . ARG A 1 931  ? 133.591 130.352 150.769 1.00 77.86  ? 1276 ARG A NH2   1 
ATOM   4169 N  N     . SER A 1 932  ? 141.046 133.476 149.547 1.00 63.15  ? 1277 SER A N     1 
ATOM   4170 C  CA    . SER A 1 932  ? 142.125 133.865 150.456 1.00 57.32  ? 1277 SER A CA    1 
ATOM   4171 C  C     . SER A 1 932  ? 142.744 132.663 151.159 1.00 58.74  ? 1277 SER A C     1 
ATOM   4172 O  O     . SER A 1 932  ? 143.248 132.781 152.276 1.00 62.45  ? 1277 SER A O     1 
ATOM   4173 C  CB    . SER A 1 932  ? 141.647 134.889 151.489 1.00 56.49  ? 1277 SER A CB    1 
ATOM   4174 O  OG    . SER A 1 932  ? 141.197 136.072 150.858 1.00 70.41  ? 1277 SER A OG    1 
ATOM   4175 N  N     . MET A 1 933  ? 142.719 131.496 150.514 1.00 56.52  ? 1278 MET A N     1 
ATOM   4176 C  CA    . MET A 1 933  ? 143.302 130.313 151.137 1.00 54.32  ? 1278 MET A CA    1 
ATOM   4177 C  C     . MET A 1 933  ? 144.818 130.420 151.216 1.00 59.86  ? 1278 MET A C     1 
ATOM   4178 O  O     . MET A 1 933  ? 145.425 129.966 152.191 1.00 71.99  ? 1278 MET A O     1 
ATOM   4179 C  CB    . MET A 1 933  ? 142.894 129.055 150.376 1.00 57.76  ? 1278 MET A CB    1 
ATOM   4180 C  CG    . MET A 1 933  ? 143.351 127.768 151.034 1.00 61.70  ? 1278 MET A CG    1 
ATOM   4181 S  SD    . MET A 1 933  ? 142.869 127.656 152.766 1.00 75.57  ? 1278 MET A SD    1 
ATOM   4182 C  CE    . MET A 1 933  ? 141.085 127.686 152.626 1.00 63.31  ? 1278 MET A CE    1 
ATOM   4183 N  N     . VAL A 1 934  ? 145.450 131.015 150.204 1.00 50.43  ? 1279 VAL A N     1 
ATOM   4184 C  CA    . VAL A 1 934  ? 146.907 131.098 150.200 1.00 51.31  ? 1279 VAL A CA    1 
ATOM   4185 C  C     . VAL A 1 934  ? 147.397 132.070 151.267 1.00 53.88  ? 1279 VAL A C     1 
ATOM   4186 O  O     . VAL A 1 934  ? 148.371 131.792 151.974 1.00 60.73  ? 1279 VAL A O     1 
ATOM   4187 C  CB    . VAL A 1 934  ? 147.422 131.480 148.803 1.00 44.80  ? 1279 VAL A CB    1 
ATOM   4188 C  CG1   . VAL A 1 934  ? 148.938 131.512 148.795 1.00 45.80  ? 1279 VAL A CG1   1 
ATOM   4189 C  CG2   . VAL A 1 934  ? 146.911 130.495 147.773 1.00 50.47  ? 1279 VAL A CG2   1 
ATOM   4190 N  N     . LEU A 1 935  ? 146.741 133.225 151.400 1.00 45.41  ? 1280 LEU A N     1 
ATOM   4191 C  CA    . LEU A 1 935  ? 147.129 134.167 152.445 1.00 41.30  ? 1280 LEU A CA    1 
ATOM   4192 C  C     . LEU A 1 935  ? 146.911 133.572 153.829 1.00 47.54  ? 1280 LEU A C     1 
ATOM   4193 O  O     . LEU A 1 935  ? 147.751 133.731 154.723 1.00 56.85  ? 1280 LEU A O     1 
ATOM   4194 C  CB    . LEU A 1 935  ? 146.350 135.472 152.301 1.00 47.79  ? 1280 LEU A CB    1 
ATOM   4195 C  CG    . LEU A 1 935  ? 146.541 136.477 153.437 1.00 42.54  ? 1280 LEU A CG    1 
ATOM   4196 C  CD1   . LEU A 1 935  ? 147.639 137.466 153.099 1.00 42.20  ? 1280 LEU A CD1   1 
ATOM   4197 C  CD2   . LEU A 1 935  ? 145.243 137.201 153.738 1.00 46.24  ? 1280 LEU A CD2   1 
ATOM   4198 N  N     . LYS A 1 936  ? 145.787 132.879 154.023 1.00 40.56  ? 1281 LYS A N     1 
ATOM   4199 C  CA    . LYS A 1 936  ? 145.525 132.246 155.309 1.00 28.11  ? 1281 LYS A CA    1 
ATOM   4200 C  C     . LYS A 1 936  ? 146.567 131.181 155.620 1.00 37.56  ? 1281 LYS A C     1 
ATOM   4201 O  O     . LYS A 1 936  ? 147.036 131.077 156.758 1.00 51.45  ? 1281 LYS A O     1 
ATOM   4202 C  CB    . LYS A 1 936  ? 144.119 131.652 155.320 1.00 32.04  ? 1281 LYS A CB    1 
ATOM   4203 C  CG    . LYS A 1 936  ? 143.060 132.626 155.792 1.00 44.13  ? 1281 LYS A CG    1 
ATOM   4204 C  CD    . LYS A 1 936  ? 141.732 132.415 155.095 1.00 47.80  ? 1281 LYS A CD    1 
ATOM   4205 C  CE    . LYS A 1 936  ? 141.124 131.076 155.446 1.00 45.98  ? 1281 LYS A CE    1 
ATOM   4206 N  NZ    . LYS A 1 936  ? 139.684 131.029 155.086 1.00 45.70  ? 1281 LYS A NZ    1 
ATOM   4207 N  N     . LEU A 1 937  ? 146.953 130.388 154.619 1.00 43.16  ? 1282 LEU A N     1 
ATOM   4208 C  CA    . LEU A 1 937  ? 147.971 129.367 154.839 1.00 36.27  ? 1282 LEU A CA    1 
ATOM   4209 C  C     . LEU A 1 937  ? 149.327 129.989 155.147 1.00 45.35  ? 1282 LEU A C     1 
ATOM   4210 O  O     . LEU A 1 937  ? 150.063 129.486 156.003 1.00 56.73  ? 1282 LEU A O     1 
ATOM   4211 C  CB    . LEU A 1 937  ? 148.065 128.451 153.624 1.00 33.24  ? 1282 LEU A CB    1 
ATOM   4212 C  CG    . LEU A 1 937  ? 146.988 127.373 153.534 1.00 38.01  ? 1282 LEU A CG    1 
ATOM   4213 C  CD1   . LEU A 1 937  ? 146.970 126.756 152.151 1.00 49.19  ? 1282 LEU A CD1   1 
ATOM   4214 C  CD2   . LEU A 1 937  ? 147.219 126.312 154.588 1.00 44.85  ? 1282 LEU A CD2   1 
ATOM   4215 N  N     . THR A 1 938  ? 149.680 131.078 154.460 1.00 42.22  ? 1283 THR A N     1 
ATOM   4216 C  CA    . THR A 1 938  ? 150.941 131.754 154.753 1.00 33.42  ? 1283 THR A CA    1 
ATOM   4217 C  C     . THR A 1 938  ? 150.953 132.299 156.173 1.00 38.99  ? 1283 THR A C     1 
ATOM   4218 O  O     . THR A 1 938  ? 151.954 132.172 156.887 1.00 48.09  ? 1283 THR A O     1 
ATOM   4219 C  CB    . THR A 1 938  ? 151.186 132.879 153.750 1.00 28.37  ? 1283 THR A CB    1 
ATOM   4220 O  OG1   . THR A 1 938  ? 151.481 132.319 152.467 1.00 55.05  ? 1283 THR A OG1   1 
ATOM   4221 C  CG2   . THR A 1 938  ? 152.351 133.740 154.192 1.00 22.76  ? 1283 THR A CG2   1 
ATOM   4222 N  N     . LEU A 1 939  ? 149.845 132.902 156.605 1.00 44.54  ? 1284 LEU A N     1 
ATOM   4223 C  CA    . LEU A 1 939  ? 149.773 133.407 157.971 1.00 38.31  ? 1284 LEU A CA    1 
ATOM   4224 C  C     . LEU A 1 939  ? 149.846 132.271 158.984 1.00 34.84  ? 1284 LEU A C     1 
ATOM   4225 O  O     . LEU A 1 939  ? 150.491 132.405 160.032 1.00 40.29  ? 1284 LEU A O     1 
ATOM   4226 C  CB    . LEU A 1 939  ? 148.499 134.225 158.160 1.00 33.05  ? 1284 LEU A CB    1 
ATOM   4227 C  CG    . LEU A 1 939  ? 148.429 135.499 157.318 1.00 33.32  ? 1284 LEU A CG    1 
ATOM   4228 C  CD1   . LEU A 1 939  ? 147.091 136.187 157.499 1.00 46.95  ? 1284 LEU A CD1   1 
ATOM   4229 C  CD2   . LEU A 1 939  ? 149.572 136.437 157.663 1.00 28.79  ? 1284 LEU A CD2   1 
ATOM   4230 N  N     . ARG A 1 940  ? 149.193 131.143 158.692 1.00 32.15  ? 1285 ARG A N     1 
ATOM   4231 C  CA    . ARG A 1 940  ? 149.270 129.998 159.592 1.00 28.47  ? 1285 ARG A CA    1 
ATOM   4232 C  C     . ARG A 1 940  ? 150.696 129.484 159.708 1.00 36.83  ? 1285 ARG A C     1 
ATOM   4233 O  O     . ARG A 1 940  ? 151.160 129.168 160.808 1.00 50.67  ? 1285 ARG A O     1 
ATOM   4234 C  CB    . ARG A 1 940  ? 148.347 128.883 159.117 1.00 28.69  ? 1285 ARG A CB    1 
ATOM   4235 C  CG    . ARG A 1 940  ? 148.544 127.581 159.868 1.00 34.18  ? 1285 ARG A CG    1 
ATOM   4236 C  CD    . ARG A 1 940  ? 147.954 127.655 161.262 1.00 44.70  ? 1285 ARG A CD    1 
ATOM   4237 N  NE    . ARG A 1 940  ? 148.278 126.479 162.060 1.00 47.24  ? 1285 ARG A NE    1 
ATOM   4238 C  CZ    . ARG A 1 940  ? 149.130 126.474 163.075 1.00 44.40  ? 1285 ARG A CZ    1 
ATOM   4239 N  NH1   . ARG A 1 940  ? 149.766 127.571 163.447 1.00 42.02  ? 1285 ARG A NH1   1 
ATOM   4240 N  NH2   . ARG A 1 940  ? 149.348 125.340 163.734 1.00 42.21  ? 1285 ARG A NH2   1 
ATOM   4241 N  N     . CYS A 1 941  ? 151.410 129.395 158.583 1.00 32.20  ? 1286 CYS A N     1 
ATOM   4242 C  CA    . CYS A 1 941  ? 152.808 128.974 158.633 1.00 26.59  ? 1286 CYS A CA    1 
ATOM   4243 C  C     . CYS A 1 941  ? 153.650 129.958 159.433 1.00 39.25  ? 1286 CYS A C     1 
ATOM   4244 O  O     . CYS A 1 941  ? 154.494 129.551 160.240 1.00 47.75  ? 1286 CYS A O     1 
ATOM   4245 C  CB    . CYS A 1 941  ? 153.371 128.825 157.222 1.00 32.05  ? 1286 CYS A CB    1 
ATOM   4246 S  SG    . CYS A 1 941  ? 152.712 127.430 156.299 1.00 65.39  ? 1286 CYS A SG    1 
ATOM   4247 N  N     . LEU A 1 942  ? 153.428 131.257 159.231 1.00 44.26  ? 1287 LEU A N     1 
ATOM   4248 C  CA    . LEU A 1 942  ? 154.225 132.257 159.933 1.00 39.20  ? 1287 LEU A CA    1 
ATOM   4249 C  C     . LEU A 1 942  ? 153.991 132.203 161.438 1.00 40.71  ? 1287 LEU A C     1 
ATOM   4250 O  O     . LEU A 1 942  ? 154.934 132.364 162.220 1.00 43.34  ? 1287 LEU A O     1 
ATOM   4251 C  CB    . LEU A 1 942  ? 153.920 133.651 159.392 1.00 37.66  ? 1287 LEU A CB    1 
ATOM   4252 C  CG    . LEU A 1 942  ? 154.919 134.193 158.370 1.00 35.47  ? 1287 LEU A CG    1 
ATOM   4253 C  CD1   . LEU A 1 942  ? 156.293 134.279 158.986 1.00 36.82  ? 1287 LEU A CD1   1 
ATOM   4254 C  CD2   . LEU A 1 942  ? 154.954 133.333 157.129 1.00 41.59  ? 1287 LEU A CD2   1 
ATOM   4255 N  N     . VAL A 1 943  ? 152.747 131.987 161.870 1.00 42.75  ? 1288 VAL A N     1 
ATOM   4256 C  CA    . VAL A 1 943  ? 152.510 131.880 163.308 1.00 32.55  ? 1288 VAL A CA    1 
ATOM   4257 C  C     . VAL A 1 943  ? 152.929 130.524 163.863 1.00 40.43  ? 1288 VAL A C     1 
ATOM   4258 O  O     . VAL A 1 943  ? 153.194 130.416 165.066 1.00 46.36  ? 1288 VAL A O     1 
ATOM   4259 C  CB    . VAL A 1 943  ? 151.045 132.152 163.689 1.00 28.63  ? 1288 VAL A CB    1 
ATOM   4260 C  CG1   . VAL A 1 943  ? 150.532 133.380 162.980 1.00 35.94  ? 1288 VAL A CG1   1 
ATOM   4261 C  CG2   . VAL A 1 943  ? 150.170 130.952 163.396 1.00 33.52  ? 1288 VAL A CG2   1 
ATOM   4262 N  N     . ARG A 1 944  ? 152.999 129.485 163.028 1.00 41.54  ? 1289 ARG A N     1 
ATOM   4263 C  CA    . ARG A 1 944  ? 153.494 128.197 163.502 1.00 41.52  ? 1289 ARG A CA    1 
ATOM   4264 C  C     . ARG A 1 944  ? 155.007 128.217 163.662 1.00 38.66  ? 1289 ARG A C     1 
ATOM   4265 O  O     . ARG A 1 944  ? 155.552 127.543 164.542 1.00 49.10  ? 1289 ARG A O     1 
ATOM   4266 C  CB    . ARG A 1 944  ? 153.046 127.088 162.553 1.00 40.86  ? 1289 ARG A CB    1 
ATOM   4267 C  CG    . ARG A 1 944  ? 153.768 125.762 162.710 1.00 40.20  ? 1289 ARG A CG    1 
ATOM   4268 C  CD    . ARG A 1 944  ? 153.614 125.145 164.092 1.00 48.73  ? 1289 ARG A CD    1 
ATOM   4269 N  NE    . ARG A 1 944  ? 154.699 124.214 164.380 1.00 49.17  ? 1289 ARG A NE    1 
ATOM   4270 C  CZ    . ARG A 1 944  ? 155.635 124.415 165.296 1.00 50.51  ? 1289 ARG A CZ    1 
ATOM   4271 N  NH1   . ARG A 1 944  ? 155.658 125.513 166.032 1.00 47.63  ? 1289 ARG A NH1   1 
ATOM   4272 N  NH2   . ARG A 1 944  ? 156.574 123.490 165.479 1.00 51.44  ? 1289 ARG A NH2   1 
ATOM   4273 N  N     . MET A 1 945  ? 155.704 128.990 162.828 1.00 39.49  ? 1290 MET A N     1 
ATOM   4274 C  CA    . MET A 1 945  ? 157.135 129.180 163.034 1.00 45.01  ? 1290 MET A CA    1 
ATOM   4275 C  C     . MET A 1 945  ? 157.411 129.825 164.384 1.00 51.32  ? 1290 MET A C     1 
ATOM   4276 O  O     . MET A 1 945  ? 158.339 129.424 165.096 1.00 55.13  ? 1290 MET A O     1 
ATOM   4277 C  CB    . MET A 1 945  ? 157.725 130.036 161.915 1.00 41.19  ? 1290 MET A CB    1 
ATOM   4278 C  CG    . MET A 1 945  ? 158.594 129.288 160.929 1.00 44.87  ? 1290 MET A CG    1 
ATOM   4279 S  SD    . MET A 1 945  ? 158.751 130.156 159.356 1.00 71.36  ? 1290 MET A SD    1 
ATOM   4280 C  CE    . MET A 1 945  ? 157.131 129.920 158.648 1.00 57.98  ? 1290 MET A CE    1 
ATOM   4281 N  N     . GLY A 1 946  ? 156.610 130.817 164.759 1.00 37.41  ? 1291 GLY A N     1 
ATOM   4282 C  CA    . GLY A 1 946  ? 156.841 131.572 165.972 1.00 30.20  ? 1291 GLY A CA    1 
ATOM   4283 C  C     . GLY A 1 946  ? 157.017 133.043 165.673 1.00 38.28  ? 1291 GLY A C     1 
ATOM   4284 O  O     . GLY A 1 946  ? 157.484 133.811 166.516 1.00 45.60  ? 1291 GLY A O     1 
ATOM   4285 N  N     . TYR A 1 947  ? 156.632 133.443 164.468 1.00 39.70  ? 1292 TYR A N     1 
ATOM   4286 C  CA    . TYR A 1 947  ? 156.821 134.799 163.981 1.00 35.48  ? 1292 TYR A CA    1 
ATOM   4287 C  C     . TYR A 1 947  ? 155.627 135.673 164.350 1.00 44.86  ? 1292 TYR A C     1 
ATOM   4288 O  O     . TYR A 1 947  ? 154.534 135.184 164.640 1.00 58.53  ? 1292 TYR A O     1 
ATOM   4289 C  CB    . TYR A 1 947  ? 157.001 134.790 162.465 1.00 37.42  ? 1292 TYR A CB    1 
ATOM   4290 C  CG    . TYR A 1 947  ? 158.435 134.744 162.002 1.00 42.02  ? 1292 TYR A CG    1 
ATOM   4291 C  CD1   . TYR A 1 947  ? 159.241 135.865 162.063 1.00 46.04  ? 1292 TYR A CD1   1 
ATOM   4292 C  CD2   . TYR A 1 947  ? 158.979 133.578 161.490 1.00 38.81  ? 1292 TYR A CD2   1 
ATOM   4293 C  CE1   . TYR A 1 947  ? 160.546 135.825 161.638 1.00 42.77  ? 1292 TYR A CE1   1 
ATOM   4294 C  CE2   . TYR A 1 947  ? 160.281 133.531 161.061 1.00 34.86  ? 1292 TYR A CE2   1 
ATOM   4295 C  CZ    . TYR A 1 947  ? 161.058 134.656 161.138 1.00 39.24  ? 1292 TYR A CZ    1 
ATOM   4296 O  OH    . TYR A 1 947  ? 162.360 134.617 160.713 1.00 56.20  ? 1292 TYR A OH    1 
ATOM   4297 N  N     . GLN A 1 948  ? 155.850 136.983 164.334 1.00 26.11  ? 1293 GLN A N     1 
ATOM   4298 C  CA    . GLN A 1 948  ? 154.776 137.963 164.439 1.00 28.90  ? 1293 GLN A CA    1 
ATOM   4299 C  C     . GLN A 1 948  ? 154.464 138.459 163.034 1.00 45.50  ? 1293 GLN A C     1 
ATOM   4300 O  O     . GLN A 1 948  ? 155.229 139.244 162.469 1.00 61.08  ? 1293 GLN A O     1 
ATOM   4301 C  CB    . GLN A 1 948  ? 155.171 139.124 165.346 1.00 28.19  ? 1293 GLN A CB    1 
ATOM   4302 C  CG    . GLN A 1 948  ? 156.288 138.827 166.309 1.00 28.44  ? 1293 GLN A CG    1 
ATOM   4303 C  CD    . GLN A 1 948  ? 156.516 139.967 167.277 1.00 38.01  ? 1293 GLN A CD    1 
ATOM   4304 O  OE1   . GLN A 1 948  ? 155.772 140.132 168.237 1.00 48.92  ? 1293 GLN A OE1   1 
ATOM   4305 N  NE2   . GLN A 1 948  ? 157.544 140.763 167.027 1.00 44.14  ? 1293 GLN A NE2   1 
ATOM   4306 N  N     . CYS A 1 949  ? 153.344 138.018 162.472 1.00 31.21  ? 1294 CYS A N     1 
ATOM   4307 C  CA    . CYS A 1 949  ? 153.029 138.278 161.076 1.00 37.43  ? 1294 CYS A CA    1 
ATOM   4308 C  C     . CYS A 1 949  ? 151.836 139.214 160.947 1.00 48.98  ? 1294 CYS A C     1 
ATOM   4309 O  O     . CYS A 1 949  ? 150.886 139.139 161.730 1.00 61.55  ? 1294 CYS A O     1 
ATOM   4310 C  CB    . CYS A 1 949  ? 152.737 136.976 160.333 1.00 41.60  ? 1294 CYS A CB    1 
ATOM   4311 S  SG    . CYS A 1 949  ? 151.265 136.117 160.897 1.00 67.54  ? 1294 CYS A SG    1 
ATOM   4312 N  N     . THR A 1 950  ? 151.898 140.094 159.950 1.00 48.01  ? 1295 THR A N     1 
ATOM   4313 C  CA    . THR A 1 950  ? 150.788 140.959 159.585 1.00 39.00  ? 1295 THR A CA    1 
ATOM   4314 C  C     . THR A 1 950  ? 150.708 141.037 158.069 1.00 47.79  ? 1295 THR A C     1 
ATOM   4315 O  O     . THR A 1 950  ? 151.693 140.808 157.364 1.00 57.87  ? 1295 THR A O     1 
ATOM   4316 C  CB    . THR A 1 950  ? 150.936 142.365 160.170 1.00 41.22  ? 1295 THR A CB    1 
ATOM   4317 O  OG1   . THR A 1 950  ? 149.797 143.153 159.809 1.00 57.31  ? 1295 THR A OG1   1 
ATOM   4318 C  CG2   . THR A 1 950  ? 152.181 143.032 159.630 1.00 46.15  ? 1295 THR A CG2   1 
ATOM   4319 N  N     . PHE A 1 951  ? 149.520 141.361 157.568 1.00 45.93  ? 1296 PHE A N     1 
ATOM   4320 C  CA    . PHE A 1 951  ? 149.290 141.466 156.136 1.00 49.88  ? 1296 PHE A CA    1 
ATOM   4321 C  C     . PHE A 1 951  ? 148.533 142.747 155.825 1.00 54.34  ? 1296 PHE A C     1 
ATOM   4322 O  O     . PHE A 1 951  ? 147.761 143.247 156.647 1.00 59.75  ? 1296 PHE A O     1 
ATOM   4323 C  CB    . PHE A 1 951  ? 148.507 140.266 155.603 1.00 47.44  ? 1296 PHE A CB    1 
ATOM   4324 C  CG    . PHE A 1 951  ? 147.023 140.398 155.753 1.00 46.52  ? 1296 PHE A CG    1 
ATOM   4325 C  CD1   . PHE A 1 951  ? 146.427 140.258 156.991 1.00 47.71  ? 1296 PHE A CD1   1 
ATOM   4326 C  CD2   . PHE A 1 951  ? 146.223 140.658 154.657 1.00 48.10  ? 1296 PHE A CD2   1 
ATOM   4327 C  CE1   . PHE A 1 951  ? 145.062 140.376 157.134 1.00 49.11  ? 1296 PHE A CE1   1 
ATOM   4328 C  CE2   . PHE A 1 951  ? 144.856 140.779 154.795 1.00 57.55  ? 1296 PHE A CE2   1 
ATOM   4329 C  CZ    . PHE A 1 951  ? 144.275 140.637 156.035 1.00 57.04  ? 1296 PHE A CZ    1 
ATOM   4330 N  N     . GLY A 1 952  ? 148.760 143.273 154.626 1.00 44.75  ? 1297 GLY A N     1 
ATOM   4331 C  CA    . GLY A 1 952  ? 148.048 144.468 154.210 1.00 43.71  ? 1297 GLY A CA    1 
ATOM   4332 C  C     . GLY A 1 952  ? 148.180 144.676 152.720 1.00 49.87  ? 1297 GLY A C     1 
ATOM   4333 O  O     . GLY A 1 952  ? 148.889 143.945 152.027 1.00 52.65  ? 1297 GLY A O     1 
ATOM   4334 N  N     . VAL A 1 953  ? 147.470 145.689 152.233 1.00 48.23  ? 1298 VAL A N     1 
ATOM   4335 C  CA    . VAL A 1 953  ? 147.505 146.085 150.832 1.00 45.88  ? 1298 VAL A CA    1 
ATOM   4336 C  C     . VAL A 1 953  ? 147.898 147.552 150.768 1.00 42.12  ? 1298 VAL A C     1 
ATOM   4337 O  O     . VAL A 1 953  ? 147.284 148.392 151.434 1.00 40.49  ? 1298 VAL A O     1 
ATOM   4338 C  CB    . VAL A 1 953  ? 146.152 145.846 150.139 1.00 50.31  ? 1298 VAL A CB    1 
ATOM   4339 C  CG1   . VAL A 1 953  ? 146.199 146.335 148.708 1.00 52.58  ? 1298 VAL A CG1   1 
ATOM   4340 C  CG2   . VAL A 1 953  ? 145.789 144.375 150.181 1.00 51.93  ? 1298 VAL A CG2   1 
ATOM   4341 N  N     . LEU A 1 954  ? 148.918 147.858 149.974 1.00 40.38  ? 1299 LEU A N     1 
ATOM   4342 C  CA    . LEU A 1 954  ? 149.446 149.207 149.857 1.00 35.41  ? 1299 LEU A CA    1 
ATOM   4343 C  C     . LEU A 1 954  ? 149.274 149.711 148.434 1.00 36.03  ? 1299 LEU A C     1 
ATOM   4344 O  O     . LEU A 1 954  ? 149.488 148.969 147.471 1.00 40.27  ? 1299 LEU A O     1 
ATOM   4345 C  CB    . LEU A 1 954  ? 150.924 149.259 150.245 1.00 40.85  ? 1299 LEU A CB    1 
ATOM   4346 C  CG    . LEU A 1 954  ? 151.249 149.002 151.713 1.00 40.03  ? 1299 LEU A CG    1 
ATOM   4347 C  CD1   . LEU A 1 954  ? 152.738 149.130 151.953 1.00 35.57  ? 1299 LEU A CD1   1 
ATOM   4348 C  CD2   . LEU A 1 954  ? 150.475 149.957 152.597 1.00 42.81  ? 1299 LEU A CD2   1 
ATOM   4349 N  N     . GLN A 1 955  ? 148.894 150.977 148.308 1.00 37.02  ? 1300 GLN A N     1 
ATOM   4350 C  CA    . GLN A 1 955  ? 148.788 151.631 147.012 1.00 40.10  ? 1300 GLN A CA    1 
ATOM   4351 C  C     . GLN A 1 955  ? 150.128 152.270 146.680 1.00 44.87  ? 1300 GLN A C     1 
ATOM   4352 O  O     . GLN A 1 955  ? 150.622 153.108 147.439 1.00 52.86  ? 1300 GLN A O     1 
ATOM   4353 C  CB    . GLN A 1 955  ? 147.684 152.682 147.025 1.00 37.41  ? 1300 GLN A CB    1 
ATOM   4354 C  CG    . GLN A 1 955  ? 147.706 153.600 145.830 1.00 27.72  ? 1300 GLN A CG    1 
ATOM   4355 C  CD    . GLN A 1 955  ? 147.076 152.968 144.618 1.00 29.81  ? 1300 GLN A CD    1 
ATOM   4356 O  OE1   . GLN A 1 955  ? 147.745 152.709 143.623 1.00 31.89  ? 1300 GLN A OE1   1 
ATOM   4357 N  NE2   . GLN A 1 955  ? 145.781 152.708 144.695 1.00 45.82  ? 1300 GLN A NE2   1 
ATOM   4358 N  N     . ALA A 1 956  ? 150.717 151.874 145.552 1.00 51.27  ? 1301 ALA A N     1 
ATOM   4359 C  CA    . ALA A 1 956  ? 152.031 152.390 145.192 1.00 38.67  ? 1301 ALA A CA    1 
ATOM   4360 C  C     . ALA A 1 956  ? 151.990 153.878 144.877 1.00 36.69  ? 1301 ALA A C     1 
ATOM   4361 O  O     . ALA A 1 956  ? 152.975 154.584 145.116 1.00 46.80  ? 1301 ALA A O     1 
ATOM   4362 C  CB    . ALA A 1 956  ? 152.595 151.613 144.004 1.00 37.63  ? 1301 ALA A CB    1 
ATOM   4363 N  N     . GLY A 1 957  ? 150.869 154.373 144.358 1.00 26.78  ? 1302 GLY A N     1 
ATOM   4364 C  CA    . GLY A 1 957  ? 150.788 155.758 143.932 1.00 37.24  ? 1302 GLY A CA    1 
ATOM   4365 C  C     . GLY A 1 957  ? 150.721 156.768 145.057 1.00 39.83  ? 1302 GLY A C     1 
ATOM   4366 O  O     . GLY A 1 957  ? 150.888 157.965 144.797 1.00 34.00  ? 1302 GLY A O     1 
ATOM   4367 N  N     . GLN A 1 958  ? 150.479 156.325 146.286 1.00 37.86  ? 1303 GLN A N     1 
ATOM   4368 C  CA    . GLN A 1 958  ? 150.407 157.213 147.436 1.00 25.12  ? 1303 GLN A CA    1 
ATOM   4369 C  C     . GLN A 1 958  ? 151.759 157.454 148.085 1.00 29.94  ? 1303 GLN A C     1 
ATOM   4370 O  O     . GLN A 1 958  ? 151.830 158.194 149.068 1.00 40.08  ? 1303 GLN A O     1 
ATOM   4371 C  CB    . GLN A 1 958  ? 149.446 156.646 148.482 1.00 22.99  ? 1303 GLN A CB    1 
ATOM   4372 C  CG    . GLN A 1 958  ? 147.987 156.803 148.135 1.00 28.32  ? 1303 GLN A CG    1 
ATOM   4373 C  CD    . GLN A 1 958  ? 147.086 156.246 149.209 1.00 40.19  ? 1303 GLN A CD    1 
ATOM   4374 O  OE1   . GLN A 1 958  ? 145.982 156.737 149.425 1.00 53.18  ? 1303 GLN A OE1   1 
ATOM   4375 N  NE2   . GLN A 1 958  ? 147.557 155.214 149.896 1.00 34.70  ? 1303 GLN A NE2   1 
ATOM   4376 N  N     . TYR A 1 959  ? 152.826 156.842 147.574 1.00 36.09  ? 1304 TYR A N     1 
ATOM   4377 C  CA    . TYR A 1 959  ? 154.138 156.938 148.199 1.00 32.97  ? 1304 TYR A CA    1 
ATOM   4378 C  C     . TYR A 1 959  ? 155.166 157.626 147.314 1.00 36.62  ? 1304 TYR A C     1 
ATOM   4379 O  O     . TYR A 1 959  ? 156.335 157.720 147.703 1.00 45.58  ? 1304 TYR A O     1 
ATOM   4380 C  CB    . TYR A 1 959  ? 154.637 155.548 148.599 1.00 47.50  ? 1304 TYR A CB    1 
ATOM   4381 C  CG    . TYR A 1 959  ? 153.788 154.895 149.662 1.00 43.82  ? 1304 TYR A CG    1 
ATOM   4382 C  CD1   . TYR A 1 959  ? 153.941 155.223 150.998 1.00 37.67  ? 1304 TYR A CD1   1 
ATOM   4383 C  CD2   . TYR A 1 959  ? 152.826 153.959 149.327 1.00 38.54  ? 1304 TYR A CD2   1 
ATOM   4384 C  CE1   . TYR A 1 959  ? 153.163 154.634 151.966 1.00 40.69  ? 1304 TYR A CE1   1 
ATOM   4385 C  CE2   . TYR A 1 959  ? 152.044 153.367 150.287 1.00 29.83  ? 1304 TYR A CE2   1 
ATOM   4386 C  CZ    . TYR A 1 959  ? 152.216 153.708 151.603 1.00 37.67  ? 1304 TYR A CZ    1 
ATOM   4387 O  OH    . TYR A 1 959  ? 151.435 153.114 152.563 1.00 41.52  ? 1304 TYR A OH    1 
ATOM   4388 N  N     . GLY A 1 960  ? 154.768 158.125 146.148 1.00 42.23  ? 1305 GLY A N     1 
ATOM   4389 C  CA    . GLY A 1 960  ? 155.686 158.890 145.329 1.00 35.22  ? 1305 GLY A CA    1 
ATOM   4390 C  C     . GLY A 1 960  ? 155.586 158.676 143.834 1.00 37.24  ? 1305 GLY A C     1 
ATOM   4391 O  O     . GLY A 1 960  ? 155.846 159.605 143.067 1.00 46.46  ? 1305 GLY A O     1 
ATOM   4392 N  N     . VAL A 1 961  ? 155.211 157.476 143.396 1.00 36.29  ? 1306 VAL A N     1 
ATOM   4393 C  CA    . VAL A 1 961  ? 155.120 157.207 141.965 1.00 38.61  ? 1306 VAL A CA    1 
ATOM   4394 C  C     . VAL A 1 961  ? 153.862 157.858 141.414 1.00 41.37  ? 1306 VAL A C     1 
ATOM   4395 O  O     . VAL A 1 961  ? 152.979 158.275 142.171 1.00 43.22  ? 1306 VAL A O     1 
ATOM   4396 C  CB    . VAL A 1 961  ? 155.131 155.699 141.660 1.00 29.37  ? 1306 VAL A CB    1 
ATOM   4397 C  CG1   . VAL A 1 961  ? 156.251 155.019 142.401 1.00 35.64  ? 1306 VAL A CG1   1 
ATOM   4398 C  CG2   . VAL A 1 961  ? 153.800 155.073 142.007 1.00 31.18  ? 1306 VAL A CG2   1 
ATOM   4399 N  N     . ALA A 1 962  ? 153.778 157.956 140.090 1.00 36.04  ? 1307 ALA A N     1 
ATOM   4400 C  CA    . ALA A 1 962  ? 152.610 158.487 139.394 1.00 29.06  ? 1307 ALA A CA    1 
ATOM   4401 C  C     . ALA A 1 962  ? 151.786 157.375 138.774 1.00 32.16  ? 1307 ALA A C     1 
ATOM   4402 O  O     . ALA A 1 962  ? 151.284 157.513 137.659 1.00 41.51  ? 1307 ALA A O     1 
ATOM   4403 C  CB    . ALA A 1 962  ? 153.038 159.488 138.328 1.00 37.78  ? 1307 ALA A CB    1 
ATOM   4404 N  N     . GLN A 1 963  ? 151.651 156.251 139.470 1.00 44.44  ? 1308 GLN A N     1 
ATOM   4405 C  CA    . GLN A 1 963  ? 151.081 155.048 138.888 1.00 46.20  ? 1308 GLN A CA    1 
ATOM   4406 C  C     . GLN A 1 963  ? 150.281 154.290 139.933 1.00 42.19  ? 1308 GLN A C     1 
ATOM   4407 O  O     . GLN A 1 963  ? 150.738 154.114 141.064 1.00 53.04  ? 1308 GLN A O     1 
ATOM   4408 C  CB    . GLN A 1 963  ? 152.186 154.157 138.324 1.00 36.62  ? 1308 GLN A CB    1 
ATOM   4409 C  CG    . GLN A 1 963  ? 151.725 152.813 137.844 1.00 40.31  ? 1308 GLN A CG    1 
ATOM   4410 C  CD    . GLN A 1 963  ? 152.845 151.810 137.842 1.00 47.44  ? 1308 GLN A CD    1 
ATOM   4411 O  OE1   . GLN A 1 963  ? 152.651 150.646 138.170 1.00 46.08  ? 1308 GLN A OE1   1 
ATOM   4412 N  NE2   . GLN A 1 963  ? 154.037 152.264 137.486 1.00 48.69  ? 1308 GLN A NE2   1 
ATOM   4413 N  N     . THR A 1 964  ? 149.091 153.839 139.550 1.00 34.97  ? 1309 THR A N     1 
ATOM   4414 C  CA    . THR A 1 964  ? 148.259 153.046 140.444 1.00 42.56  ? 1309 THR A CA    1 
ATOM   4415 C  C     . THR A 1 964  ? 148.749 151.602 140.451 1.00 52.77  ? 1309 THR A C     1 
ATOM   4416 O  O     . THR A 1 964  ? 148.854 150.966 139.398 1.00 62.07  ? 1309 THR A O     1 
ATOM   4417 C  CB    . THR A 1 964  ? 146.790 153.137 140.031 1.00 42.10  ? 1309 THR A CB    1 
ATOM   4418 O  OG1   . THR A 1 964  ? 145.999 152.282 140.865 1.00 49.56  ? 1309 THR A OG1   1 
ATOM   4419 C  CG2   . THR A 1 964  ? 146.592 152.764 138.571 1.00 42.16  ? 1309 THR A CG2   1 
ATOM   4420 N  N     . ARG A 1 965  ? 149.078 151.091 141.639 1.00 47.78  ? 1310 ARG A N     1 
ATOM   4421 C  CA    . ARG A 1 965  ? 149.568 149.720 141.766 1.00 41.24  ? 1310 ARG A CA    1 
ATOM   4422 C  C     . ARG A 1 965  ? 149.296 149.262 143.196 1.00 45.24  ? 1310 ARG A C     1 
ATOM   4423 O  O     . ARG A 1 965  ? 150.046 149.615 144.109 1.00 50.65  ? 1310 ARG A O     1 
ATOM   4424 C  CB    . ARG A 1 965  ? 151.045 149.634 141.428 1.00 41.33  ? 1310 ARG A CB    1 
ATOM   4425 C  CG    . ARG A 1 965  ? 151.436 148.356 140.724 1.00 51.17  ? 1310 ARG A CG    1 
ATOM   4426 C  CD    . ARG A 1 965  ? 152.877 148.398 140.264 1.00 47.64  ? 1310 ARG A CD    1 
ATOM   4427 N  NE    . ARG A 1 965  ? 153.183 147.287 139.374 1.00 47.40  ? 1310 ARG A NE    1 
ATOM   4428 C  CZ    . ARG A 1 965  ? 154.396 146.790 139.190 1.00 50.36  ? 1310 ARG A CZ    1 
ATOM   4429 N  NH1   . ARG A 1 965  ? 155.449 147.289 139.814 1.00 51.42  ? 1310 ARG A NH1   1 
ATOM   4430 N  NH2   . ARG A 1 965  ? 154.558 145.768 138.355 1.00 53.01  ? 1310 ARG A NH2   1 
ATOM   4431 N  N     . ARG A 1 966  ? 148.242 148.475 143.376 1.00 43.49  ? 1311 ARG A N     1 
ATOM   4432 C  CA    . ARG A 1 966  ? 147.883 147.958 144.688 1.00 44.61  ? 1311 ARG A CA    1 
ATOM   4433 C  C     . ARG A 1 966  ? 148.566 146.611 144.894 1.00 52.50  ? 1311 ARG A C     1 
ATOM   4434 O  O     . ARG A 1 966  ? 148.247 145.637 144.204 1.00 53.50  ? 1311 ARG A O     1 
ATOM   4435 C  CB    . ARG A 1 966  ? 146.367 147.834 144.815 1.00 46.08  ? 1311 ARG A CB    1 
ATOM   4436 C  CG    . ARG A 1 966  ? 145.621 149.073 144.358 1.00 48.05  ? 1311 ARG A CG    1 
ATOM   4437 C  CD    . ARG A 1 966  ? 144.127 148.899 144.506 1.00 45.31  ? 1311 ARG A CD    1 
ATOM   4438 N  NE    . ARG A 1 966  ? 143.688 147.598 144.021 1.00 47.85  ? 1311 ARG A NE    1 
ATOM   4439 C  CZ    . ARG A 1 966  ? 142.422 147.213 143.956 1.00 56.22  ? 1311 ARG A CZ    1 
ATOM   4440 N  NH1   . ARG A 1 966  ? 141.438 148.007 144.344 1.00 57.52  ? 1311 ARG A NH1   1 
ATOM   4441 N  NH2   . ARG A 1 966  ? 142.136 146.001 143.489 1.00 52.80  ? 1311 ARG A NH2   1 
ATOM   4442 N  N     . ARG A 1 967  ? 149.502 146.560 145.837 1.00 47.20  ? 1312 ARG A N     1 
ATOM   4443 C  CA    . ARG A 1 967  ? 150.323 145.382 146.071 1.00 45.11  ? 1312 ARG A CA    1 
ATOM   4444 C  C     . ARG A 1 967  ? 150.139 144.891 147.500 1.00 45.28  ? 1312 ARG A C     1 
ATOM   4445 O  O     . ARG A 1 967  ? 150.064 145.690 148.436 1.00 45.75  ? 1312 ARG A O     1 
ATOM   4446 C  CB    . ARG A 1 967  ? 151.804 145.679 145.810 1.00 37.72  ? 1312 ARG A CB    1 
ATOM   4447 C  CG    . ARG A 1 967  ? 152.164 145.833 144.341 1.00 43.34  ? 1312 ARG A CG    1 
ATOM   4448 C  CD    . ARG A 1 967  ? 151.922 144.548 143.572 1.00 46.14  ? 1312 ARG A CD    1 
ATOM   4449 N  NE    . ARG A 1 967  ? 151.876 144.762 142.131 1.00 47.89  ? 1312 ARG A NE    1 
ATOM   4450 C  CZ    . ARG A 1 967  ? 150.762 144.776 141.412 1.00 49.93  ? 1312 ARG A CZ    1 
ATOM   4451 N  NH1   . ARG A 1 967  ? 149.576 144.609 141.972 1.00 49.11  ? 1312 ARG A NH1   1 
ATOM   4452 N  NH2   . ARG A 1 967  ? 150.840 144.960 140.099 1.00 54.28  ? 1312 ARG A NH2   1 
ATOM   4453 N  N     . ALA A 1 968  ? 150.071 143.573 147.661 1.00 50.48  ? 1313 ALA A N     1 
ATOM   4454 C  CA    . ALA A 1 968  ? 149.896 142.954 148.966 1.00 45.66  ? 1313 ALA A CA    1 
ATOM   4455 C  C     . ALA A 1 968  ? 151.251 142.710 149.614 1.00 51.60  ? 1313 ALA A C     1 
ATOM   4456 O  O     . ALA A 1 968  ? 152.141 142.107 149.005 1.00 63.04  ? 1313 ALA A O     1 
ATOM   4457 C  CB    . ALA A 1 968  ? 149.132 141.638 148.840 1.00 42.47  ? 1313 ALA A CB    1 
ATOM   4458 N  N     . ILE A 1 969  ? 151.394 143.169 150.855 1.00 38.21  ? 1314 ILE A N     1 
ATOM   4459 C  CA    . ILE A 1 969  ? 152.631 143.074 151.618 1.00 43.68  ? 1314 ILE A CA    1 
ATOM   4460 C  C     . ILE A 1 969  ? 152.365 142.240 152.861 1.00 44.35  ? 1314 ILE A C     1 
ATOM   4461 O  O     . ILE A 1 969  ? 151.394 142.488 153.587 1.00 53.75  ? 1314 ILE A O     1 
ATOM   4462 C  CB    . ILE A 1 969  ? 153.164 144.465 152.007 1.00 37.81  ? 1314 ILE A CB    1 
ATOM   4463 C  CG1   . ILE A 1 969  ? 153.268 145.367 150.777 1.00 40.97  ? 1314 ILE A CG1   1 
ATOM   4464 C  CG2   . ILE A 1 969  ? 154.504 144.346 152.709 1.00 41.39  ? 1314 ILE A CG2   1 
ATOM   4465 C  CD1   . ILE A 1 969  ? 154.442 145.053 149.887 1.00 50.44  ? 1314 ILE A CD1   1 
ATOM   4466 N  N     . ILE A 1 970  ? 153.226 141.257 153.106 1.00 42.80  ? 1315 ILE A N     1 
ATOM   4467 C  CA    . ILE A 1 970  ? 153.188 140.442 154.313 1.00 41.83  ? 1315 ILE A CA    1 
ATOM   4468 C  C     . ILE A 1 970  ? 154.493 140.667 155.057 1.00 42.28  ? 1315 ILE A C     1 
ATOM   4469 O  O     . ILE A 1 970  ? 155.578 140.475 154.491 1.00 57.64  ? 1315 ILE A O     1 
ATOM   4470 C  CB    . ILE A 1 970  ? 152.991 138.952 153.995 1.00 44.05  ? 1315 ILE A CB    1 
ATOM   4471 C  CG1   . ILE A 1 970  ? 151.526 138.662 153.683 1.00 40.69  ? 1315 ILE A CG1   1 
ATOM   4472 C  CG2   . ILE A 1 970  ? 153.459 138.091 155.154 1.00 39.19  ? 1315 ILE A CG2   1 
ATOM   4473 C  CD1   . ILE A 1 970  ? 151.245 137.202 153.475 1.00 45.41  ? 1315 ILE A CD1   1 
ATOM   4474 N  N     . LEU A 1 971  ? 154.389 141.072 156.318 1.00 19.19  ? 1316 LEU A N     1 
ATOM   4475 C  CA    . LEU A 1 971  ? 155.539 141.364 157.155 1.00 31.61  ? 1316 LEU A CA    1 
ATOM   4476 C  C     . LEU A 1 971  ? 155.602 140.380 158.313 1.00 42.66  ? 1316 LEU A C     1 
ATOM   4477 O  O     . LEU A 1 971  ? 154.573 139.937 158.829 1.00 54.92  ? 1316 LEU A O     1 
ATOM   4478 C  CB    . LEU A 1 971  ? 155.480 142.791 157.700 1.00 39.52  ? 1316 LEU A CB    1 
ATOM   4479 C  CG    . LEU A 1 971  ? 156.180 143.873 156.885 1.00 48.06  ? 1316 LEU A CG    1 
ATOM   4480 C  CD1   . LEU A 1 971  ? 155.652 145.242 157.265 1.00 39.44  ? 1316 LEU A CD1   1 
ATOM   4481 C  CD2   . LEU A 1 971  ? 157.677 143.797 157.114 1.00 56.38  ? 1316 LEU A CD2   1 
ATOM   4482 N  N     . ALA A 1 972  ? 156.821 140.034 158.713 1.00 44.15  ? 1317 ALA A N     1 
ATOM   4483 C  CA    . ALA A 1 972  ? 157.028 139.189 159.876 1.00 26.57  ? 1317 ALA A CA    1 
ATOM   4484 C  C     . ALA A 1 972  ? 158.325 139.591 160.560 1.00 37.58  ? 1317 ALA A C     1 
ATOM   4485 O  O     . ALA A 1 972  ? 159.274 140.045 159.918 1.00 59.11  ? 1317 ALA A O     1 
ATOM   4486 C  CB    . ALA A 1 972  ? 157.054 137.709 159.494 1.00 27.82  ? 1317 ALA A CB    1 
ATOM   4487 N  N     . ALA A 1 973  ? 158.367 139.400 161.875 1.00 24.38  ? 1318 ALA A N     1 
ATOM   4488 C  CA    . ALA A 1 973  ? 159.544 139.752 162.653 1.00 25.91  ? 1318 ALA A CA    1 
ATOM   4489 C  C     . ALA A 1 973  ? 159.772 138.694 163.719 1.00 32.23  ? 1318 ALA A C     1 
ATOM   4490 O  O     . ALA A 1 973  ? 158.830 138.052 164.185 1.00 48.58  ? 1318 ALA A O     1 
ATOM   4491 C  CB    . ALA A 1 973  ? 159.397 141.134 163.294 1.00 28.85  ? 1318 ALA A CB    1 
ATOM   4492 N  N     . ALA A 1 974  ? 161.036 138.530 164.106 1.00 35.13  ? 1319 ALA A N     1 
ATOM   4493 C  CA    . ALA A 1 974  ? 161.395 137.553 165.117 1.00 41.88  ? 1319 ALA A CA    1 
ATOM   4494 C  C     . ALA A 1 974  ? 160.785 137.941 166.462 1.00 47.65  ? 1319 ALA A C     1 
ATOM   4495 O  O     . ALA A 1 974  ? 160.494 139.114 166.702 1.00 57.74  ? 1319 ALA A O     1 
ATOM   4496 C  CB    . ALA A 1 974  ? 162.915 137.447 165.231 1.00 48.41  ? 1319 ALA A CB    1 
ATOM   4497 N  N     . PRO A 1 975  ? 160.577 136.967 167.356 1.00 43.91  ? 1320 PRO A N     1 
ATOM   4498 C  CA    . PRO A 1 975  ? 159.897 137.272 168.625 1.00 48.72  ? 1320 PRO A CA    1 
ATOM   4499 C  C     . PRO A 1 975  ? 160.576 138.353 169.444 1.00 53.11  ? 1320 PRO A C     1 
ATOM   4500 O  O     . PRO A 1 975  ? 159.889 139.106 170.145 1.00 54.70  ? 1320 PRO A O     1 
ATOM   4501 C  CB    . PRO A 1 975  ? 159.910 135.925 169.357 1.00 48.38  ? 1320 PRO A CB    1 
ATOM   4502 C  CG    . PRO A 1 975  ? 159.978 134.922 168.277 1.00 51.79  ? 1320 PRO A CG    1 
ATOM   4503 C  CD    . PRO A 1 975  ? 160.841 135.526 167.215 1.00 51.36  ? 1320 PRO A CD    1 
ATOM   4504 N  N     . GLY A 1 976  ? 161.903 138.455 169.385 1.00 55.23  ? 1321 GLY A N     1 
ATOM   4505 C  CA    . GLY A 1 976  ? 162.576 139.543 170.068 1.00 57.80  ? 1321 GLY A CA    1 
ATOM   4506 C  C     . GLY A 1 976  ? 162.346 140.897 169.432 1.00 55.29  ? 1321 GLY A C     1 
ATOM   4507 O  O     . GLY A 1 976  ? 162.542 141.921 170.093 1.00 64.67  ? 1321 GLY A O     1 
ATOM   4508 N  N     . GLU A 1 977  ? 161.932 140.923 168.169 1.00 45.33  ? 1322 GLU A N     1 
ATOM   4509 C  CA    . GLU A 1 977  ? 161.744 142.161 167.433 1.00 50.20  ? 1322 GLU A CA    1 
ATOM   4510 C  C     . GLU A 1 977  ? 160.310 142.666 167.582 1.00 58.45  ? 1322 GLU A C     1 
ATOM   4511 O  O     . GLU A 1 977  ? 159.460 142.039 168.219 1.00 54.72  ? 1322 GLU A O     1 
ATOM   4512 C  CB    . GLU A 1 977  ? 162.096 141.960 165.961 1.00 50.58  ? 1322 GLU A CB    1 
ATOM   4513 C  CG    . GLU A 1 977  ? 163.346 141.138 165.730 1.00 56.25  ? 1322 GLU A CG    1 
ATOM   4514 C  CD    . GLU A 1 977  ? 164.605 141.968 165.832 1.00 59.75  ? 1322 GLU A CD    1 
ATOM   4515 O  OE1   . GLU A 1 977  ? 164.503 143.209 165.753 1.00 60.61  ? 1322 GLU A OE1   1 
ATOM   4516 O  OE2   . GLU A 1 977  ? 165.697 141.384 165.988 1.00 61.71  ? 1322 GLU A OE2   1 
ATOM   4517 N  N     . LYS A 1 978  ? 160.041 143.819 166.978 1.00 61.23  ? 1323 LYS A N     1 
ATOM   4518 C  CA    . LYS A 1 978  ? 158.722 144.430 166.973 1.00 55.75  ? 1323 LYS A CA    1 
ATOM   4519 C  C     . LYS A 1 978  ? 158.156 144.403 165.561 1.00 59.26  ? 1323 LYS A C     1 
ATOM   4520 O  O     . LYS A 1 978  ? 158.874 144.660 164.591 1.00 57.66  ? 1323 LYS A O     1 
ATOM   4521 C  CB    . LYS A 1 978  ? 158.782 145.872 167.479 1.00 56.00  ? 1323 LYS A CB    1 
ATOM   4522 C  CG    . LYS A 1 978  ? 159.795 146.097 168.585 1.00 59.95  ? 1323 LYS A CG    1 
ATOM   4523 C  CD    . LYS A 1 978  ? 159.935 147.574 168.908 1.00 64.36  ? 1323 LYS A CD    1 
ATOM   4524 C  CE    . LYS A 1 978  ? 158.700 148.101 169.617 1.00 65.88  ? 1323 LYS A CE    1 
ATOM   4525 N  NZ    . LYS A 1 978  ? 158.354 147.280 170.810 1.00 63.08  ? 1323 LYS A NZ    1 
ATOM   4526 N  N     . LEU A 1 979  ? 156.876 144.093 165.450 1.00 54.53  ? 1324 LEU A N     1 
ATOM   4527 C  CA    . LEU A 1 979  ? 156.239 144.013 164.142 1.00 48.10  ? 1324 LEU A CA    1 
ATOM   4528 C  C     . LEU A 1 979  ? 156.056 145.412 163.572 1.00 47.47  ? 1324 LEU A C     1 
ATOM   4529 O  O     . LEU A 1 979  ? 155.402 146.249 164.208 1.00 49.30  ? 1324 LEU A O     1 
ATOM   4530 C  CB    . LEU A 1 979  ? 154.898 143.301 164.256 1.00 44.43  ? 1324 LEU A CB    1 
ATOM   4531 C  CG    . LEU A 1 979  ? 154.137 143.072 162.955 1.00 41.46  ? 1324 LEU A CG    1 
ATOM   4532 C  CD1   . LEU A 1 979  ? 155.023 142.384 161.951 1.00 45.65  ? 1324 LEU A CD1   1 
ATOM   4533 C  CD2   . LEU A 1 979  ? 152.905 142.243 163.217 1.00 44.86  ? 1324 LEU A CD2   1 
ATOM   4534 N  N     . PRO A 1 980  ? 156.612 145.716 162.402 1.00 46.02  ? 1325 PRO A N     1 
ATOM   4535 C  CA    . PRO A 1 980  ? 156.493 147.071 161.857 1.00 42.49  ? 1325 PRO A CA    1 
ATOM   4536 C  C     . PRO A 1 980  ? 155.069 147.428 161.465 1.00 48.95  ? 1325 PRO A C     1 
ATOM   4537 O  O     . PRO A 1 980  ? 154.271 146.579 161.061 1.00 49.46  ? 1325 PRO A O     1 
ATOM   4538 C  CB    . PRO A 1 980  ? 157.411 147.041 160.629 1.00 38.79  ? 1325 PRO A CB    1 
ATOM   4539 C  CG    . PRO A 1 980  ? 158.339 145.909 160.872 1.00 45.50  ? 1325 PRO A CG    1 
ATOM   4540 C  CD    . PRO A 1 980  ? 157.540 144.890 161.614 1.00 53.56  ? 1325 PRO A CD    1 
ATOM   4541 N  N     . LEU A 1 981  ? 154.762 148.714 161.589 1.00 52.68  ? 1326 LEU A N     1 
ATOM   4542 C  CA    . LEU A 1 981  ? 153.502 149.266 161.121 1.00 49.36  ? 1326 LEU A CA    1 
ATOM   4543 C  C     . LEU A 1 981  ? 153.623 149.649 159.653 1.00 46.42  ? 1326 LEU A C     1 
ATOM   4544 O  O     . LEU A 1 981  ? 154.695 150.032 159.179 1.00 53.04  ? 1326 LEU A O     1 
ATOM   4545 C  CB    . LEU A 1 981  ? 153.111 150.494 161.943 1.00 46.17  ? 1326 LEU A CB    1 
ATOM   4546 C  CG    . LEU A 1 981  ? 152.913 150.323 163.448 1.00 47.88  ? 1326 LEU A CG    1 
ATOM   4547 C  CD1   . LEU A 1 981  ? 153.442 151.539 164.182 1.00 44.54  ? 1326 LEU A CD1   1 
ATOM   4548 C  CD2   . LEU A 1 981  ? 151.448 150.107 163.770 1.00 44.46  ? 1326 LEU A CD2   1 
ATOM   4549 N  N     . PHE A 1 982  ? 152.513 149.542 158.934 1.00 38.75  ? 1327 PHE A N     1 
ATOM   4550 C  CA    . PHE A 1 982  ? 152.514 149.923 157.531 1.00 48.41  ? 1327 PHE A CA    1 
ATOM   4551 C  C     . PHE A 1 982  ? 152.709 151.433 157.403 1.00 51.83  ? 1327 PHE A C     1 
ATOM   4552 O  O     . PHE A 1 982  ? 152.237 152.193 158.252 1.00 50.94  ? 1327 PHE A O     1 
ATOM   4553 C  CB    . PHE A 1 982  ? 151.214 149.495 156.860 1.00 49.17  ? 1327 PHE A CB    1 
ATOM   4554 C  CG    . PHE A 1 982  ? 151.210 148.064 156.419 1.00 39.84  ? 1327 PHE A CG    1 
ATOM   4555 C  CD1   . PHE A 1 982  ? 152.168 147.595 155.545 1.00 42.19  ? 1327 PHE A CD1   1 
ATOM   4556 C  CD2   . PHE A 1 982  ? 150.254 147.185 156.886 1.00 48.82  ? 1327 PHE A CD2   1 
ATOM   4557 C  CE1   . PHE A 1 982  ? 152.168 146.279 155.142 1.00 50.50  ? 1327 PHE A CE1   1 
ATOM   4558 C  CE2   . PHE A 1 982  ? 150.252 145.869 156.487 1.00 46.72  ? 1327 PHE A CE2   1 
ATOM   4559 C  CZ    . PHE A 1 982  ? 151.208 145.417 155.615 1.00 45.56  ? 1327 PHE A CZ    1 
ATOM   4560 N  N     . PRO A 1 983  ? 153.401 151.894 156.364 1.00 51.61  ? 1328 PRO A N     1 
ATOM   4561 C  CA    . PRO A 1 983  ? 153.727 153.321 156.271 1.00 50.83  ? 1328 PRO A CA    1 
ATOM   4562 C  C     . PRO A 1 983  ? 152.490 154.175 156.053 1.00 51.75  ? 1328 PRO A C     1 
ATOM   4563 O  O     . PRO A 1 983  ? 151.471 153.717 155.530 1.00 55.60  ? 1328 PRO A O     1 
ATOM   4564 C  CB    . PRO A 1 983  ? 154.669 153.397 155.063 1.00 52.34  ? 1328 PRO A CB    1 
ATOM   4565 C  CG    . PRO A 1 983  ? 155.027 151.981 154.731 1.00 50.87  ? 1328 PRO A CG    1 
ATOM   4566 C  CD    . PRO A 1 983  ? 153.902 151.137 155.208 1.00 48.45  ? 1328 PRO A CD    1 
ATOM   4567 N  N     . GLU A 1 984  ? 152.589 155.434 156.472 1.00 51.31  ? 1329 GLU A N     1 
ATOM   4568 C  CA    . GLU A 1 984  ? 151.498 156.375 156.264 1.00 52.22  ? 1329 GLU A CA    1 
ATOM   4569 C  C     . GLU A 1 984  ? 151.598 156.997 154.873 1.00 57.76  ? 1329 GLU A C     1 
ATOM   4570 O  O     . GLU A 1 984  ? 152.696 157.329 154.422 1.00 53.29  ? 1329 GLU A O     1 
ATOM   4571 C  CB    . GLU A 1 984  ? 151.522 157.472 157.325 1.00 50.10  ? 1329 GLU A CB    1 
ATOM   4572 C  CG    . GLU A 1 984  ? 151.174 156.992 158.723 1.00 62.48  ? 1329 GLU A CG    1 
ATOM   4573 C  CD    . GLU A 1 984  ? 149.691 157.075 159.019 1.00 64.12  ? 1329 GLU A CD    1 
ATOM   4574 O  OE1   . GLU A 1 984  ? 148.892 156.548 158.218 1.00 60.20  ? 1329 GLU A OE1   1 
ATOM   4575 O  OE2   . GLU A 1 984  ? 149.321 157.665 160.056 1.00 59.39  ? 1329 GLU A OE2   1 
ATOM   4576 N  N     . PRO A 1 985  ? 150.473 157.162 154.179 1.00 51.95  ? 1330 PRO A N     1 
ATOM   4577 C  CA    . PRO A 1 985  ? 150.513 157.736 152.830 1.00 46.02  ? 1330 PRO A CA    1 
ATOM   4578 C  C     . PRO A 1 985  ? 151.089 159.143 152.836 1.00 47.29  ? 1330 PRO A C     1 
ATOM   4579 O  O     . PRO A 1 985  ? 150.882 159.915 153.772 1.00 52.10  ? 1330 PRO A O     1 
ATOM   4580 C  CB    . PRO A 1 985  ? 149.041 157.737 152.403 1.00 51.94  ? 1330 PRO A CB    1 
ATOM   4581 C  CG    . PRO A 1 985  ? 148.395 156.712 153.262 1.00 51.80  ? 1330 PRO A CG    1 
ATOM   4582 C  CD    . PRO A 1 985  ? 149.113 156.763 154.569 1.00 50.36  ? 1330 PRO A CD    1 
ATOM   4583 N  N     . LEU A 1 986  ? 151.820 159.468 151.775 1.00 39.88  ? 1331 LEU A N     1 
ATOM   4584 C  CA    . LEU A 1 986  ? 152.453 160.772 151.622 1.00 34.45  ? 1331 LEU A CA    1 
ATOM   4585 C  C     . LEU A 1 986  ? 151.805 161.633 150.553 1.00 31.41  ? 1331 LEU A C     1 
ATOM   4586 O  O     . LEU A 1 986  ? 151.671 162.841 150.743 1.00 49.39  ? 1331 LEU A O     1 
ATOM   4587 C  CB    . LEU A 1 986  ? 153.938 160.602 151.292 1.00 37.05  ? 1331 LEU A CB    1 
ATOM   4588 C  CG    . LEU A 1 986  ? 154.879 160.319 152.460 1.00 37.42  ? 1331 LEU A CG    1 
ATOM   4589 C  CD1   . LEU A 1 986  ? 156.130 159.621 151.968 1.00 33.86  ? 1331 LEU A CD1   1 
ATOM   4590 C  CD2   . LEU A 1 986  ? 155.233 161.606 153.173 1.00 42.36  ? 1331 LEU A CD2   1 
ATOM   4591 N  N     . HIS A 1 987  ? 151.398 161.046 149.435 1.00 19.64  ? 1332 HIS A N     1 
ATOM   4592 C  CA    . HIS A 1 987  ? 150.815 161.783 148.327 1.00 19.31  ? 1332 HIS A CA    1 
ATOM   4593 C  C     . HIS A 1 987  ? 149.353 161.398 148.167 1.00 33.72  ? 1332 HIS A C     1 
ATOM   4594 O  O     . HIS A 1 987  ? 148.999 160.219 148.257 1.00 52.30  ? 1332 HIS A O     1 
ATOM   4595 C  CB    . HIS A 1 987  ? 151.576 161.507 147.027 1.00 28.84  ? 1332 HIS A CB    1 
ATOM   4596 C  CG    . HIS A 1 987  ? 153.004 161.953 147.054 1.00 25.72  ? 1332 HIS A CG    1 
ATOM   4597 N  ND1   . HIS A 1 987  ? 153.546 162.772 146.089 1.00 29.76  ? 1332 HIS A ND1   1 
ATOM   4598 C  CD2   . HIS A 1 987  ? 154.003 161.693 147.929 1.00 29.65  ? 1332 HIS A CD2   1 
ATOM   4599 C  CE1   . HIS A 1 987  ? 154.817 162.999 146.369 1.00 28.82  ? 1332 HIS A CE1   1 
ATOM   4600 N  NE2   . HIS A 1 987  ? 155.119 162.354 147.480 1.00 29.24  ? 1332 HIS A NE2   1 
ATOM   4601 N  N     . VAL A 1 988  ? 148.502 162.397 147.937 1.00 37.63  ? 1333 VAL A N     1 
ATOM   4602 C  CA    . VAL A 1 988  ? 147.090 162.131 147.707 1.00 36.53  ? 1333 VAL A CA    1 
ATOM   4603 C  C     . VAL A 1 988  ? 146.919 161.355 146.406 1.00 45.99  ? 1333 VAL A C     1 
ATOM   4604 O  O     . VAL A 1 988  ? 147.709 161.491 145.464 1.00 53.15  ? 1333 VAL A O     1 
ATOM   4605 C  CB    . VAL A 1 988  ? 146.293 163.446 147.673 1.00 30.01  ? 1333 VAL A CB    1 
ATOM   4606 C  CG1   . VAL A 1 988  ? 144.835 163.186 147.971 1.00 43.31  ? 1333 VAL A CG1   1 
ATOM   4607 C  CG2   . VAL A 1 988  ? 146.868 164.434 148.660 1.00 41.18  ? 1333 VAL A CG2   1 
ATOM   4608 N  N     . PHE A 1 989  ? 145.881 160.525 146.351 1.00 48.64  ? 1334 PHE A N     1 
ATOM   4609 C  CA    . PHE A 1 989  ? 145.592 159.736 145.164 1.00 43.62  ? 1334 PHE A CA    1 
ATOM   4610 C  C     . PHE A 1 989  ? 144.087 159.678 144.948 1.00 52.97  ? 1334 PHE A C     1 
ATOM   4611 O  O     . PHE A 1 989  ? 143.295 159.992 145.840 1.00 54.67  ? 1334 PHE A O     1 
ATOM   4612 C  CB    . PHE A 1 989  ? 146.179 158.326 145.270 1.00 37.79  ? 1334 PHE A CB    1 
ATOM   4613 C  CG    . PHE A 1 989  ? 146.781 157.829 143.991 1.00 48.57  ? 1334 PHE A CG    1 
ATOM   4614 C  CD1   . PHE A 1 989  ? 147.935 158.400 143.489 1.00 46.39  ? 1334 PHE A CD1   1 
ATOM   4615 C  CD2   . PHE A 1 989  ? 146.193 156.793 143.290 1.00 50.95  ? 1334 PHE A CD2   1 
ATOM   4616 C  CE1   . PHE A 1 989  ? 148.490 157.949 142.315 1.00 44.75  ? 1334 PHE A CE1   1 
ATOM   4617 C  CE2   . PHE A 1 989  ? 146.744 156.338 142.117 1.00 42.33  ? 1334 PHE A CE2   1 
ATOM   4618 C  CZ    . PHE A 1 989  ? 147.894 156.917 141.629 1.00 41.28  ? 1334 PHE A CZ    1 
ATOM   4619 N  N     . ALA A 1 990  ? 143.700 159.267 143.744 1.00 68.06  ? 1335 ALA A N     1 
ATOM   4620 C  CA    . ALA A 1 990  ? 142.292 159.242 143.380 1.00 70.09  ? 1335 ALA A CA    1 
ATOM   4621 C  C     . ALA A 1 990  ? 141.525 158.290 144.295 1.00 73.05  ? 1335 ALA A C     1 
ATOM   4622 O  O     . ALA A 1 990  ? 142.011 157.195 144.599 1.00 71.76  ? 1335 ALA A O     1 
ATOM   4623 C  CB    . ALA A 1 990  ? 142.124 158.815 141.922 1.00 68.14  ? 1335 ALA A CB    1 
ATOM   4624 N  N     . PRO A 1 991  ? 140.331 158.674 144.754 1.00 84.22  ? 1336 PRO A N     1 
ATOM   4625 C  CA    . PRO A 1 991  ? 139.580 157.800 145.671 1.00 86.17  ? 1336 PRO A CA    1 
ATOM   4626 C  C     . PRO A 1 991  ? 139.240 156.444 145.080 1.00 85.46  ? 1336 PRO A C     1 
ATOM   4627 O  O     . PRO A 1 991  ? 139.211 155.449 145.815 1.00 77.77  ? 1336 PRO A O     1 
ATOM   4628 C  CB    . PRO A 1 991  ? 138.313 158.614 145.974 1.00 81.53  ? 1336 PRO A CB    1 
ATOM   4629 C  CG    . PRO A 1 991  ? 138.654 160.019 145.612 1.00 79.73  ? 1336 PRO A CG    1 
ATOM   4630 C  CD    . PRO A 1 991  ? 139.611 159.925 144.470 1.00 80.84  ? 1336 PRO A CD    1 
ATOM   4631 N  N     . ARG A 1 992  ? 138.977 156.371 143.775 1.00 92.89  ? 1337 ARG A N     1 
ATOM   4632 C  CA    . ARG A 1 992  ? 138.648 155.095 143.154 1.00 90.71  ? 1337 ARG A CA    1 
ATOM   4633 C  C     . ARG A 1 992  ? 139.832 154.143 143.098 1.00 92.50  ? 1337 ARG A C     1 
ATOM   4634 O  O     . ARG A 1 992  ? 139.636 152.959 142.806 1.00 97.51  ? 1337 ARG A O     1 
ATOM   4635 C  CB    . ARG A 1 992  ? 138.105 155.316 141.742 1.00 90.16  ? 1337 ARG A CB    1 
ATOM   4636 C  CG    . ARG A 1 992  ? 136.901 154.455 141.409 1.00 90.64  ? 1337 ARG A CG    1 
ATOM   4637 C  CD    . ARG A 1 992  ? 136.659 154.394 139.913 1.00 90.49  ? 1337 ARG A CD    1 
ATOM   4638 N  NE    . ARG A 1 992  ? 135.598 155.303 139.497 1.00 92.46  ? 1337 ARG A NE    1 
ATOM   4639 C  CZ    . ARG A 1 992  ? 134.328 154.952 139.344 1.00 94.25  ? 1337 ARG A CZ    1 
ATOM   4640 N  NH1   . ARG A 1 992  ? 133.920 153.715 139.577 1.00 97.46  ? 1337 ARG A NH1   1 
ATOM   4641 N  NH2   . ARG A 1 992  ? 133.446 155.865 138.948 1.00 93.09  ? 1337 ARG A NH2   1 
ATOM   4642 N  N     . ALA A 1 993  ? 141.044 154.625 143.361 1.00 77.39  ? 1338 ALA A N     1 
ATOM   4643 C  CA    . ALA A 1 993  ? 142.230 153.781 143.332 1.00 77.48  ? 1338 ALA A CA    1 
ATOM   4644 C  C     . ALA A 1 993  ? 142.652 153.286 144.707 1.00 76.00  ? 1338 ALA A C     1 
ATOM   4645 O  O     . ALA A 1 993  ? 143.260 152.217 144.806 1.00 74.98  ? 1338 ALA A O     1 
ATOM   4646 C  CB    . ALA A 1 993  ? 143.398 154.535 142.689 1.00 69.61  ? 1338 ALA A CB    1 
ATOM   4647 N  N     . CYS A 1 994  ? 142.342 154.030 145.769 1.00 79.80  ? 1339 CYS A N     1 
ATOM   4648 C  CA    . CYS A 1 994  ? 142.766 153.669 147.122 1.00 83.81  ? 1339 CYS A CA    1 
ATOM   4649 C  C     . CYS A 1 994  ? 141.686 152.811 147.774 1.00 88.93  ? 1339 CYS A C     1 
ATOM   4650 O  O     . CYS A 1 994  ? 140.918 153.254 148.631 1.00 88.30  ? 1339 CYS A O     1 
ATOM   4651 C  CB    . CYS A 1 994  ? 143.063 154.919 147.939 1.00 80.71  ? 1339 CYS A CB    1 
ATOM   4652 S  SG    . CYS A 1 994  ? 143.980 156.185 147.047 1.00 80.34  ? 1339 CYS A SG    1 
ATOM   4653 N  N     . GLN A 1 995  ? 141.632 151.551 147.351 1.00 83.05  ? 1340 GLN A N     1 
ATOM   4654 C  CA    . GLN A 1 995  ? 140.751 150.543 147.937 1.00 75.65  ? 1340 GLN A CA    1 
ATOM   4655 C  C     . GLN A 1 995  ? 141.652 149.485 148.567 1.00 74.75  ? 1340 GLN A C     1 
ATOM   4656 O  O     . GLN A 1 995  ? 142.009 148.494 147.926 1.00 78.02  ? 1340 GLN A O     1 
ATOM   4657 C  CB    . GLN A 1 995  ? 139.817 149.946 146.892 1.00 72.71  ? 1340 GLN A CB    1 
ATOM   4658 C  CG    . GLN A 1 995  ? 138.993 150.976 146.143 1.00 75.21  ? 1340 GLN A CG    1 
ATOM   4659 C  CD    . GLN A 1 995  ? 138.023 151.709 147.046 1.00 81.31  ? 1340 GLN A CD    1 
ATOM   4660 O  OE1   . GLN A 1 995  ? 137.513 151.148 148.014 1.00 80.43  ? 1340 GLN A OE1   1 
ATOM   4661 N  NE2   . GLN A 1 995  ? 137.763 152.973 146.732 1.00 80.66  ? 1340 GLN A NE2   1 
ATOM   4662 N  N     . LEU A 1 996  ? 142.020 149.700 149.827 1.00 65.93  ? 1341 LEU A N     1 
ATOM   4663 C  CA    . LEU A 1 996  ? 143.001 148.866 150.504 1.00 63.29  ? 1341 LEU A CA    1 
ATOM   4664 C  C     . LEU A 1 996  ? 142.386 147.907 151.515 1.00 64.56  ? 1341 LEU A C     1 
ATOM   4665 O  O     . LEU A 1 996  ? 143.119 147.133 152.136 1.00 64.00  ? 1341 LEU A O     1 
ATOM   4666 C  CB    . LEU A 1 996  ? 144.043 149.749 151.197 1.00 68.97  ? 1341 LEU A CB    1 
ATOM   4667 C  CG    . LEU A 1 996  ? 144.464 151.002 150.429 1.00 64.87  ? 1341 LEU A CG    1 
ATOM   4668 C  CD1   . LEU A 1 996  ? 145.412 151.847 151.260 1.00 61.75  ? 1341 LEU A CD1   1 
ATOM   4669 C  CD2   . LEU A 1 996  ? 145.102 150.627 149.106 1.00 62.54  ? 1341 LEU A CD2   1 
ATOM   4670 N  N     . SER A 1 997  ? 141.071 147.937 151.700 1.00 63.33  ? 1342 SER A N     1 
ATOM   4671 C  CA    . SER A 1 997  ? 140.435 147.012 152.626 1.00 55.92  ? 1342 SER A CA    1 
ATOM   4672 C  C     . SER A 1 997  ? 140.465 145.598 152.062 1.00 56.76  ? 1342 SER A C     1 
ATOM   4673 O  O     . SER A 1 997  ? 140.335 145.392 150.853 1.00 60.69  ? 1342 SER A O     1 
ATOM   4674 C  CB    . SER A 1 997  ? 138.996 147.438 152.900 1.00 57.10  ? 1342 SER A CB    1 
ATOM   4675 O  OG    . SER A 1 997  ? 138.209 147.351 151.726 1.00 61.20  ? 1342 SER A OG    1 
ATOM   4676 N  N     . VAL A 1 998  ? 140.639 144.619 152.946 1.00 63.00  ? 1343 VAL A N     1 
ATOM   4677 C  CA    . VAL A 1 998  ? 140.709 143.213 152.567 1.00 60.45  ? 1343 VAL A CA    1 
ATOM   4678 C  C     . VAL A 1 998  ? 139.549 142.481 153.218 1.00 63.45  ? 1343 VAL A C     1 
ATOM   4679 O  O     . VAL A 1 998  ? 139.398 142.518 154.442 1.00 69.59  ? 1343 VAL A O     1 
ATOM   4680 C  CB    . VAL A 1 998  ? 142.045 142.577 152.988 1.00 61.60  ? 1343 VAL A CB    1 
ATOM   4681 C  CG1   . VAL A 1 998  ? 142.205 141.222 152.335 1.00 57.99  ? 1343 VAL A CG1   1 
ATOM   4682 C  CG2   . VAL A 1 998  ? 143.204 143.493 152.644 1.00 61.52  ? 1343 VAL A CG2   1 
ATOM   4683 N  N     . VAL A 1 999  ? 138.743 141.803 152.413 1.00 65.87  ? 1344 VAL A N     1 
ATOM   4684 C  CA    . VAL A 1 999  ? 137.615 141.033 152.921 1.00 65.83  ? 1344 VAL A CA    1 
ATOM   4685 C  C     . VAL A 1 999  ? 138.009 139.563 152.897 1.00 69.01  ? 1344 VAL A C     1 
ATOM   4686 O  O     . VAL A 1 999  ? 138.163 138.966 151.827 1.00 76.10  ? 1344 VAL A O     1 
ATOM   4687 C  CB    . VAL A 1 999  ? 136.340 141.286 152.109 1.00 63.55  ? 1344 VAL A CB    1 
ATOM   4688 C  CG1   . VAL A 1 999  ? 135.243 140.337 152.547 1.00 62.90  ? 1344 VAL A CG1   1 
ATOM   4689 C  CG2   . VAL A 1 999  ? 135.893 142.727 152.269 1.00 62.94  ? 1344 VAL A CG2   1 
ATOM   4690 N  N     . VAL A 1 1000 ? 138.176 138.977 154.079 1.00 62.30  ? 1345 VAL A N     1 
ATOM   4691 C  CA    . VAL A 1 1000 ? 138.520 137.568 154.229 1.00 60.02  ? 1345 VAL A CA    1 
ATOM   4692 C  C     . VAL A 1 1000 ? 137.417 136.906 155.037 1.00 63.84  ? 1345 VAL A C     1 
ATOM   4693 O  O     . VAL A 1 1000 ? 137.150 137.309 156.176 1.00 70.75  ? 1345 VAL A O     1 
ATOM   4694 C  CB    . VAL A 1 1000 ? 139.884 137.378 154.909 1.00 60.78  ? 1345 VAL A CB    1 
ATOM   4695 C  CG1   . VAL A 1 1000 ? 140.054 135.941 155.346 1.00 62.77  ? 1345 VAL A CG1   1 
ATOM   4696 C  CG2   . VAL A 1 1000 ? 141.004 137.782 153.973 1.00 60.09  ? 1345 VAL A CG2   1 
ATOM   4697 N  N     . ASP A 1 1001 ? 136.778 135.897 154.446 1.00 70.38  ? 1346 ASP A N     1 
ATOM   4698 C  CA    . ASP A 1 1001 ? 135.711 135.135 155.095 1.00 75.07  ? 1346 ASP A CA    1 
ATOM   4699 C  C     . ASP A 1 1001 ? 134.661 136.060 155.707 1.00 76.18  ? 1346 ASP A C     1 
ATOM   4700 O  O     . ASP A 1 1001 ? 134.249 135.903 156.859 1.00 76.57  ? 1346 ASP A O     1 
ATOM   4701 C  CB    . ASP A 1 1001 ? 136.283 134.177 156.140 1.00 79.64  ? 1346 ASP A CB    1 
ATOM   4702 C  CG    . ASP A 1 1001 ? 136.602 132.810 155.564 1.00 82.74  ? 1346 ASP A CG    1 
ATOM   4703 O  OD1   . ASP A 1 1001 ? 135.664 132.126 155.103 1.00 81.25  ? 1346 ASP A OD1   1 
ATOM   4704 O  OD2   . ASP A 1 1001 ? 137.788 132.420 155.569 1.00 81.41  ? 1346 ASP A OD2   1 
ATOM   4705 N  N     . ASP A 1 1002 ? 134.241 137.049 154.916 1.00 79.89  ? 1347 ASP A N     1 
ATOM   4706 C  CA    . ASP A 1 1002 ? 133.197 138.000 155.297 1.00 82.29  ? 1347 ASP A CA    1 
ATOM   4707 C  C     . ASP A 1 1002 ? 133.596 138.848 156.503 1.00 80.15  ? 1347 ASP A C     1 
ATOM   4708 O  O     . ASP A 1 1002 ? 132.739 139.294 157.269 1.00 78.11  ? 1347 ASP A O     1 
ATOM   4709 C  CB    . ASP A 1 1002 ? 131.867 137.289 155.564 1.00 81.70  ? 1347 ASP A CB    1 
ATOM   4710 C  CG    . ASP A 1 1002 ? 131.484 136.337 154.451 1.00 82.51  ? 1347 ASP A CG    1 
ATOM   4711 O  OD1   . ASP A 1 1002 ? 132.118 136.391 153.377 1.00 82.82  ? 1347 ASP A OD1   1 
ATOM   4712 O  OD2   . ASP A 1 1002 ? 130.548 135.534 154.650 1.00 81.99  ? 1347 ASP A OD2   1 
ATOM   4713 N  N     . LYS A 1 1003 ? 134.892 139.085 156.686 1.00 69.43  ? 1348 LYS A N     1 
ATOM   4714 C  CA    . LYS A 1 1003 ? 135.370 140.024 157.690 1.00 65.87  ? 1348 LYS A CA    1 
ATOM   4715 C  C     . LYS A 1 1003 ? 136.309 141.019 157.030 1.00 67.05  ? 1348 LYS A C     1 
ATOM   4716 O  O     . LYS A 1 1003 ? 137.173 140.634 156.237 1.00 70.18  ? 1348 LYS A O     1 
ATOM   4717 C  CB    . LYS A 1 1003 ? 136.080 139.313 158.843 1.00 69.30  ? 1348 LYS A CB    1 
ATOM   4718 C  CG    . LYS A 1 1003 ? 135.935 140.034 160.172 1.00 73.20  ? 1348 LYS A CG    1 
ATOM   4719 C  CD    . LYS A 1 1003 ? 136.991 139.597 161.169 1.00 72.54  ? 1348 LYS A CD    1 
ATOM   4720 C  CE    . LYS A 1 1003 ? 136.869 140.376 162.467 1.00 71.31  ? 1348 LYS A CE    1 
ATOM   4721 N  NZ    . LYS A 1 1003 ? 136.391 141.768 162.234 1.00 71.38  ? 1348 LYS A NZ    1 
ATOM   4722 N  N     . LYS A 1 1004 ? 136.141 142.295 157.361 1.00 59.87  ? 1349 LYS A N     1 
ATOM   4723 C  CA    . LYS A 1 1004 ? 136.855 143.376 156.694 1.00 59.69  ? 1349 LYS A CA    1 
ATOM   4724 C  C     . LYS A 1 1004 ? 138.022 143.836 157.558 1.00 61.60  ? 1349 LYS A C     1 
ATOM   4725 O  O     . LYS A 1 1004 ? 137.818 144.352 158.661 1.00 66.77  ? 1349 LYS A O     1 
ATOM   4726 C  CB    . LYS A 1 1004 ? 135.913 144.542 156.399 1.00 61.54  ? 1349 LYS A CB    1 
ATOM   4727 C  CG    . LYS A 1 1004 ? 136.573 145.707 155.686 1.00 64.32  ? 1349 LYS A CG    1 
ATOM   4728 C  CD    . LYS A 1 1004 ? 135.546 146.568 154.971 1.00 67.20  ? 1349 LYS A CD    1 
ATOM   4729 C  CE    . LYS A 1 1004 ? 136.005 148.013 154.884 1.00 67.19  ? 1349 LYS A CE    1 
ATOM   4730 N  NZ    . LYS A 1 1004 ? 136.130 148.637 156.229 1.00 67.63  ? 1349 LYS A NZ    1 
ATOM   4731 N  N     . PHE A 1 1005 ? 139.236 143.663 157.046 1.00 56.92  ? 1350 PHE A N     1 
ATOM   4732 C  CA    . PHE A 1 1005 ? 140.461 144.077 157.712 1.00 57.05  ? 1350 PHE A CA    1 
ATOM   4733 C  C     . PHE A 1 1005 ? 141.036 145.282 156.987 1.00 56.37  ? 1350 PHE A C     1 
ATOM   4734 O  O     . PHE A 1 1005 ? 141.122 145.288 155.754 1.00 64.41  ? 1350 PHE A O     1 
ATOM   4735 C  CB    . PHE A 1 1005 ? 141.495 142.950 157.726 1.00 54.43  ? 1350 PHE A CB    1 
ATOM   4736 C  CG    . PHE A 1 1005 ? 141.005 141.685 158.355 1.00 56.15  ? 1350 PHE A CG    1 
ATOM   4737 C  CD1   . PHE A 1 1005 ? 140.820 141.602 159.721 1.00 54.30  ? 1350 PHE A CD1   1 
ATOM   4738 C  CD2   . PHE A 1 1005 ? 140.738 140.576 157.581 1.00 53.38  ? 1350 PHE A CD2   1 
ATOM   4739 C  CE1   . PHE A 1 1005 ? 140.373 140.439 160.301 1.00 51.95  ? 1350 PHE A CE1   1 
ATOM   4740 C  CE2   . PHE A 1 1005 ? 140.288 139.412 158.156 1.00 58.24  ? 1350 PHE A CE2   1 
ATOM   4741 C  CZ    . PHE A 1 1005 ? 140.106 139.343 159.517 1.00 55.80  ? 1350 PHE A CZ    1 
ATOM   4742 N  N     . VAL A 1 1006 ? 141.423 146.296 157.749 1.00 60.39  ? 1351 VAL A N     1 
ATOM   4743 C  CA    . VAL A 1 1006 ? 142.101 147.469 157.220 1.00 63.20  ? 1351 VAL A CA    1 
ATOM   4744 C  C     . VAL A 1 1006 ? 143.402 147.648 157.987 1.00 67.59  ? 1351 VAL A C     1 
ATOM   4745 O  O     . VAL A 1 1006 ? 143.464 147.387 159.193 1.00 72.34  ? 1351 VAL A O     1 
ATOM   4746 C  CB    . VAL A 1 1006 ? 141.215 148.732 157.299 1.00 61.87  ? 1351 VAL A CB    1 
ATOM   4747 C  CG1   . VAL A 1 1006 ? 141.234 149.334 158.694 1.00 58.17  ? 1351 VAL A CG1   1 
ATOM   4748 C  CG2   . VAL A 1 1006 ? 141.664 149.755 156.267 1.00 65.66  ? 1351 VAL A CG2   1 
ATOM   4749 N  N     . SER A 1 1007 ? 144.451 148.049 157.277 1.00 57.51  ? 1352 SER A N     1 
ATOM   4750 C  CA    . SER A 1 1007 ? 145.750 148.226 157.903 1.00 49.62  ? 1352 SER A CA    1 
ATOM   4751 C  C     . SER A 1 1007 ? 145.699 149.386 158.893 1.00 54.80  ? 1352 SER A C     1 
ATOM   4752 O  O     . SER A 1 1007 ? 144.687 150.074 159.044 1.00 55.46  ? 1352 SER A O     1 
ATOM   4753 C  CB    . SER A 1 1007 ? 146.823 148.448 156.842 1.00 49.93  ? 1352 SER A CB    1 
ATOM   4754 O  OG    . SER A 1 1007 ? 146.398 149.387 155.872 1.00 52.24  ? 1352 SER A OG    1 
ATOM   4755 N  N     . ASN A 1 1008 ? 146.813 149.608 159.577 1.00 58.64  ? 1353 ASN A N     1 
ATOM   4756 C  CA    . ASN A 1 1008 ? 146.901 150.686 160.559 1.00 59.97  ? 1353 ASN A CA    1 
ATOM   4757 C  C     . ASN A 1 1008 ? 146.939 152.053 159.929 1.00 59.46  ? 1353 ASN A C     1 
ATOM   4758 O  O     . ASN A 1 1008 ? 147.151 153.035 160.646 1.00 63.69  ? 1353 ASN A O     1 
ATOM   4759 C  CB    . ASN A 1 1008 ? 148.137 150.492 161.433 1.00 53.17  ? 1353 ASN A CB    1 
ATOM   4760 C  CG    . ASN A 1 1008 ? 149.375 150.200 160.623 1.00 58.29  ? 1353 ASN A CG    1 
ATOM   4761 O  OD1   . ASN A 1 1008 ? 149.697 149.044 160.357 1.00 61.50  ? 1353 ASN A OD1   1 
ATOM   4762 N  ND2   . ASN A 1 1008 ? 150.075 151.249 160.214 1.00 62.18  ? 1353 ASN A ND2   1 
ATOM   4763 N  N     . ILE A 1 1009 ? 146.744 152.139 158.616 1.00 56.26  ? 1354 ILE A N     1 
ATOM   4764 C  CA    . ILE A 1 1009 ? 146.812 153.413 157.913 1.00 53.97  ? 1354 ILE A CA    1 
ATOM   4765 C  C     . ILE A 1 1009 ? 145.605 154.257 158.299 1.00 59.64  ? 1354 ILE A C     1 
ATOM   4766 O  O     . ILE A 1 1009 ? 144.455 153.829 158.147 1.00 59.07  ? 1354 ILE A O     1 
ATOM   4767 C  CB    . ILE A 1 1009 ? 146.878 153.190 156.398 1.00 50.25  ? 1354 ILE A CB    1 
ATOM   4768 C  CG1   . ILE A 1 1009 ? 148.273 152.709 155.996 1.00 49.30  ? 1354 ILE A CG1   1 
ATOM   4769 C  CG2   . ILE A 1 1009 ? 146.499 154.454 155.655 1.00 58.77  ? 1354 ILE A CG2   1 
ATOM   4770 C  CD1   . ILE A 1 1009 ? 148.510 152.703 154.507 1.00 58.58  ? 1354 ILE A CD1   1 
ATOM   4771 N  N     . THR A 1 1010 ? 145.863 155.463 158.803 1.00 63.91  ? 1355 THR A N     1 
ATOM   4772 C  CA    . THR A 1 1010 ? 144.806 156.392 159.178 1.00 59.37  ? 1355 THR A CA    1 
ATOM   4773 C  C     . THR A 1 1010 ? 144.571 157.481 158.145 1.00 63.09  ? 1355 THR A C     1 
ATOM   4774 O  O     . THR A 1 1010 ? 143.459 158.011 158.063 1.00 65.88  ? 1355 THR A O     1 
ATOM   4775 C  CB    . THR A 1 1010 ? 145.122 157.048 160.525 1.00 56.27  ? 1355 THR A CB    1 
ATOM   4776 O  OG1   . THR A 1 1010 ? 146.494 157.459 160.547 1.00 55.27  ? 1355 THR A OG1   1 
ATOM   4777 C  CG2   . THR A 1 1010 ? 144.871 156.073 161.661 1.00 62.13  ? 1355 THR A CG2   1 
ATOM   4778 N  N     . ARG A 1 1011 ? 145.587 157.832 157.359 1.00 66.05  ? 1356 ARG A N     1 
ATOM   4779 C  CA    . ARG A 1 1011 ? 145.432 158.815 156.288 1.00 63.71  ? 1356 ARG A CA    1 
ATOM   4780 C  C     . ARG A 1 1011 ? 144.719 158.132 155.131 1.00 62.93  ? 1356 ARG A C     1 
ATOM   4781 O  O     . ARG A 1 1011 ? 145.341 157.548 154.243 1.00 64.83  ? 1356 ARG A O     1 
ATOM   4782 C  CB    . ARG A 1 1011 ? 146.782 159.373 155.859 1.00 64.40  ? 1356 ARG A CB    1 
ATOM   4783 C  CG    . ARG A 1 1011 ? 147.283 160.530 156.703 1.00 63.39  ? 1356 ARG A CG    1 
ATOM   4784 C  CD    . ARG A 1 1011 ? 148.657 160.975 156.241 1.00 64.46  ? 1356 ARG A CD    1 
ATOM   4785 N  NE    . ARG A 1 1011 ? 149.388 161.682 157.283 1.00 63.83  ? 1356 ARG A NE    1 
ATOM   4786 C  CZ    . ARG A 1 1011 ? 150.709 161.699 157.385 1.00 64.42  ? 1356 ARG A CZ    1 
ATOM   4787 N  NH1   . ARG A 1 1011 ? 151.477 161.061 156.519 1.00 56.52  ? 1356 ARG A NH1   1 
ATOM   4788 N  NH2   . ARG A 1 1011 ? 151.274 162.374 158.381 1.00 67.10  ? 1356 ARG A NH2   1 
ATOM   4789 N  N     . LEU A 1 1012 ? 143.391 158.203 155.145 1.00 68.37  ? 1357 LEU A N     1 
ATOM   4790 C  CA    . LEU A 1 1012 ? 142.576 157.581 154.111 1.00 70.03  ? 1357 LEU A CA    1 
ATOM   4791 C  C     . LEU A 1 1012 ? 142.151 158.549 153.019 1.00 74.67  ? 1357 LEU A C     1 
ATOM   4792 O  O     . LEU A 1 1012 ? 142.025 158.141 151.861 1.00 72.88  ? 1357 LEU A O     1 
ATOM   4793 C  CB    . LEU A 1 1012 ? 141.326 156.950 154.732 1.00 70.39  ? 1357 LEU A CB    1 
ATOM   4794 C  CG    . LEU A 1 1012 ? 141.527 156.245 156.074 1.00 71.06  ? 1357 LEU A CG    1 
ATOM   4795 C  CD1   . LEU A 1 1012 ? 140.231 156.226 156.868 1.00 72.91  ? 1357 LEU A CD1   1 
ATOM   4796 C  CD2   . LEU A 1 1012 ? 142.050 154.834 155.866 1.00 68.50  ? 1357 LEU A CD2   1 
ATOM   4797 N  N     . SER A 1 1013 ? 141.925 159.819 153.357 1.00 72.25  ? 1358 SER A N     1 
ATOM   4798 C  CA    . SER A 1 1013 ? 141.469 160.810 152.389 1.00 68.84  ? 1358 SER A CA    1 
ATOM   4799 C  C     . SER A 1 1013 ? 142.623 161.614 151.801 1.00 68.29  ? 1358 SER A C     1 
ATOM   4800 O  O     . SER A 1 1013 ? 142.837 161.600 150.586 1.00 71.83  ? 1358 SER A O     1 
ATOM   4801 C  CB    . SER A 1 1013 ? 140.451 161.754 153.039 1.00 66.41  ? 1358 SER A CB    1 
ATOM   4802 O  OG    . SER A 1 1013 ? 141.102 162.852 153.652 1.00 69.41  ? 1358 SER A OG    1 
ATOM   4803 N  N     . SER A 1 1014 ? 143.376 162.310 152.643 1.00 60.82  ? 1359 SER A N     1 
ATOM   4804 C  CA    . SER A 1 1014 ? 144.371 163.266 152.185 1.00 58.25  ? 1359 SER A CA    1 
ATOM   4805 C  C     . SER A 1 1014 ? 145.768 162.842 152.638 1.00 59.58  ? 1359 SER A C     1 
ATOM   4806 O  O     . SER A 1 1014 ? 145.972 161.752 153.176 1.00 65.64  ? 1359 SER A O     1 
ATOM   4807 C  CB    . SER A 1 1014 ? 144.021 164.668 152.682 1.00 53.66  ? 1359 SER A CB    1 
ATOM   4808 O  OG    . SER A 1 1014 ? 142.617 164.853 152.709 1.00 58.81  ? 1359 SER A OG    1 
ATOM   4809 N  N     . GLY A 1 1015 ? 146.733 163.722 152.398 1.00 39.66  ? 1360 GLY A N     1 
ATOM   4810 C  CA    . GLY A 1 1015 ? 148.109 163.483 152.752 1.00 43.32  ? 1360 GLY A CA    1 
ATOM   4811 C  C     . GLY A 1 1015 ? 148.901 164.769 152.665 1.00 40.70  ? 1360 GLY A C     1 
ATOM   4812 O  O     . GLY A 1 1015 ? 148.409 165.787 152.171 1.00 47.90  ? 1360 GLY A O     1 
ATOM   4813 N  N     . PRO A 1 1016 ? 150.132 164.758 153.155 1.00 20.09  ? 1361 PRO A N     1 
ATOM   4814 C  CA    . PRO A 1 1016 ? 150.939 165.983 153.127 1.00 26.39  ? 1361 PRO A CA    1 
ATOM   4815 C  C     . PRO A 1 1016 ? 151.173 166.522 151.724 1.00 34.95  ? 1361 PRO A C     1 
ATOM   4816 O  O     . PRO A 1 1016 ? 150.809 167.665 151.433 1.00 40.36  ? 1361 PRO A O     1 
ATOM   4817 C  CB    . PRO A 1 1016 ? 152.256 165.556 153.791 1.00 29.17  ? 1361 PRO A CB    1 
ATOM   4818 C  CG    . PRO A 1 1016 ? 152.222 164.075 153.845 1.00 28.02  ? 1361 PRO A CG    1 
ATOM   4819 C  CD    . PRO A 1 1016 ? 150.795 163.678 153.896 1.00 29.82  ? 1361 PRO A CD    1 
ATOM   4820 N  N     . PHE A 1 1017 ? 151.757 165.716 150.846 1.00 36.92  ? 1362 PHE A N     1 
ATOM   4821 C  CA    . PHE A 1 1017 ? 152.179 166.195 149.540 1.00 34.37  ? 1362 PHE A CA    1 
ATOM   4822 C  C     . PHE A 1 1017 ? 151.110 165.953 148.480 1.00 33.46  ? 1362 PHE A C     1 
ATOM   4823 O  O     . PHE A 1 1017 ? 150.173 165.176 148.669 1.00 40.24  ? 1362 PHE A O     1 
ATOM   4824 C  CB    . PHE A 1 1017 ? 153.482 165.524 149.115 1.00 35.51  ? 1362 PHE A CB    1 
ATOM   4825 C  CG    . PHE A 1 1017 ? 154.582 165.631 150.128 1.00 30.43  ? 1362 PHE A CG    1 
ATOM   4826 C  CD1   . PHE A 1 1017 ? 154.964 166.857 150.629 1.00 31.08  ? 1362 PHE A CD1   1 
ATOM   4827 C  CD2   . PHE A 1 1017 ? 155.256 164.505 150.551 1.00 39.32  ? 1362 PHE A CD2   1 
ATOM   4828 C  CE1   . PHE A 1 1017 ? 155.981 166.954 151.545 1.00 37.41  ? 1362 PHE A CE1   1 
ATOM   4829 C  CE2   . PHE A 1 1017 ? 156.274 164.599 151.469 1.00 38.33  ? 1362 PHE A CE2   1 
ATOM   4830 C  CZ    . PHE A 1 1017 ? 156.636 165.825 151.966 1.00 34.46  ? 1362 PHE A CZ    1 
ATOM   4831 N  N     . ARG A 1 1018 ? 151.271 166.632 147.349 1.00 32.12  ? 1363 ARG A N     1 
ATOM   4832 C  CA    . ARG A 1 1018 ? 150.323 166.541 146.252 1.00 35.20  ? 1363 ARG A CA    1 
ATOM   4833 C  C     . ARG A 1 1018 ? 150.617 165.322 145.383 1.00 34.69  ? 1363 ARG A C     1 
ATOM   4834 O  O     . ARG A 1 1018 ? 151.655 164.668 145.506 1.00 56.02  ? 1363 ARG A O     1 
ATOM   4835 C  CB    . ARG A 1 1018 ? 150.362 167.808 145.405 1.00 42.45  ? 1363 ARG A CB    1 
ATOM   4836 C  CG    . ARG A 1 1018 ? 151.750 168.180 144.936 1.00 40.27  ? 1363 ARG A CG    1 
ATOM   4837 C  CD    . ARG A 1 1018 ? 151.705 169.083 143.718 1.00 46.09  ? 1363 ARG A CD    1 
ATOM   4838 N  NE    . ARG A 1 1018 ? 152.941 169.012 142.949 1.00 45.71  ? 1363 ARG A NE    1 
ATOM   4839 C  CZ    . ARG A 1 1018 ? 153.128 168.219 141.904 1.00 43.01  ? 1363 ARG A CZ    1 
ATOM   4840 N  NH1   . ARG A 1 1018 ? 152.167 167.429 141.456 1.00 44.63  ? 1363 ARG A NH1   1 
ATOM   4841 N  NH2   . ARG A 1 1018 ? 154.308 168.219 141.292 1.00 41.24  ? 1363 ARG A NH2   1 
ATOM   4842 N  N     . THR A 1 1019 ? 149.681 165.021 144.489 1.00 27.04  ? 1364 THR A N     1 
ATOM   4843 C  CA    . THR A 1 1019 ? 149.819 163.867 143.615 1.00 33.60  ? 1364 THR A CA    1 
ATOM   4844 C  C     . THR A 1 1019 ? 150.868 164.120 142.540 1.00 40.37  ? 1364 THR A C     1 
ATOM   4845 O  O     . THR A 1 1019 ? 151.061 165.247 142.079 1.00 50.30  ? 1364 THR A O     1 
ATOM   4846 C  CB    . THR A 1 1019 ? 148.483 163.536 142.954 1.00 45.36  ? 1364 THR A CB    1 
ATOM   4847 O  OG1   . THR A 1 1019 ? 147.432 163.641 143.920 1.00 59.21  ? 1364 THR A OG1   1 
ATOM   4848 C  CG2   . THR A 1 1019 ? 148.501 162.128 142.386 1.00 41.17  ? 1364 THR A CG2   1 
ATOM   4849 N  N     . ILE A 1 1020 ? 151.554 163.052 142.148 1.00 44.16  ? 1365 ILE A N     1 
ATOM   4850 C  CA    . ILE A 1 1020 ? 152.458 163.080 141.006 1.00 42.03  ? 1365 ILE A CA    1 
ATOM   4851 C  C     . ILE A 1 1020 ? 151.683 162.628 139.777 1.00 51.81  ? 1365 ILE A C     1 
ATOM   4852 O  O     . ILE A 1 1020 ? 150.978 161.613 139.817 1.00 58.34  ? 1365 ILE A O     1 
ATOM   4853 C  CB    . ILE A 1 1020 ? 153.683 162.185 141.248 1.00 28.54  ? 1365 ILE A CB    1 
ATOM   4854 C  CG1   . ILE A 1 1020 ? 154.398 162.594 142.531 1.00 35.07  ? 1365 ILE A CG1   1 
ATOM   4855 C  CG2   . ILE A 1 1020 ? 154.637 162.271 140.080 1.00 38.68  ? 1365 ILE A CG2   1 
ATOM   4856 C  CD1   . ILE A 1 1020 ? 155.095 163.928 142.440 1.00 43.95  ? 1365 ILE A CD1   1 
ATOM   4857 N  N     . THR A 1 1021 ? 151.795 163.385 138.693 1.00 39.05  ? 1366 THR A N     1 
ATOM   4858 C  CA    . THR A 1 1021 ? 151.079 163.106 137.458 1.00 32.75  ? 1366 THR A CA    1 
ATOM   4859 C  C     . THR A 1 1021 ? 152.051 162.620 136.387 1.00 35.67  ? 1366 THR A C     1 
ATOM   4860 O  O     . THR A 1 1021 ? 153.262 162.533 136.603 1.00 51.20  ? 1366 THR A O     1 
ATOM   4861 C  CB    . THR A 1 1021 ? 150.323 164.348 136.991 1.00 44.14  ? 1366 THR A CB    1 
ATOM   4862 O  OG1   . THR A 1 1021 ? 151.257 165.399 136.727 1.00 51.86  ? 1366 THR A OG1   1 
ATOM   4863 C  CG2   . THR A 1 1021 ? 149.360 164.807 138.065 1.00 47.22  ? 1366 THR A CG2   1 
ATOM   4864 N  N     . VAL A 1 1022 ? 151.502 162.292 135.217 1.00 36.40  ? 1367 VAL A N     1 
ATOM   4865 C  CA    . VAL A 1 1022 ? 152.335 161.863 134.097 1.00 28.22  ? 1367 VAL A CA    1 
ATOM   4866 C  C     . VAL A 1 1022 ? 153.217 163.008 133.621 1.00 35.35  ? 1367 VAL A C     1 
ATOM   4867 O  O     . VAL A 1 1022 ? 154.359 162.797 133.199 1.00 48.85  ? 1367 VAL A O     1 
ATOM   4868 C  CB    . VAL A 1 1022 ? 151.456 161.309 132.961 1.00 27.27  ? 1367 VAL A CB    1 
ATOM   4869 C  CG1   . VAL A 1 1022 ? 152.242 161.205 131.672 1.00 33.81  ? 1367 VAL A CG1   1 
ATOM   4870 C  CG2   . VAL A 1 1022 ? 150.897 159.958 133.342 1.00 41.57  ? 1367 VAL A CG2   1 
ATOM   4871 N  N     . ARG A 1 1023 ? 152.707 164.240 133.691 1.00 39.45  ? 1368 ARG A N     1 
ATOM   4872 C  CA    . ARG A 1 1023 ? 153.502 165.391 133.276 1.00 39.90  ? 1368 ARG A CA    1 
ATOM   4873 C  C     . ARG A 1 1023 ? 154.777 165.510 134.100 1.00 46.03  ? 1368 ARG A C     1 
ATOM   4874 O  O     . ARG A 1 1023 ? 155.842 165.833 133.565 1.00 52.39  ? 1368 ARG A O     1 
ATOM   4875 C  CB    . ARG A 1 1023 ? 152.677 166.673 133.382 1.00 37.39  ? 1368 ARG A CB    1 
ATOM   4876 C  CG    . ARG A 1 1023 ? 153.520 167.936 133.338 1.00 36.18  ? 1368 ARG A CG    1 
ATOM   4877 C  CD    . ARG A 1 1023 ? 152.707 169.170 132.995 1.00 41.63  ? 1368 ARG A CD    1 
ATOM   4878 N  NE    . ARG A 1 1023 ? 151.285 169.003 133.257 1.00 39.25  ? 1368 ARG A NE    1 
ATOM   4879 C  CZ    . ARG A 1 1023 ? 150.330 169.268 132.378 1.00 49.51  ? 1368 ARG A CZ    1 
ATOM   4880 N  NH1   . ARG A 1 1023 ? 150.613 169.693 131.158 1.00 49.14  ? 1368 ARG A NH1   1 
ATOM   4881 N  NH2   . ARG A 1 1023 ? 149.059 169.106 132.732 1.00 46.44  ? 1368 ARG A NH2   1 
ATOM   4882 N  N     . ASP A 1 1024 ? 154.693 165.254 135.404 1.00 44.17  ? 1369 ASP A N     1 
ATOM   4883 C  CA    . ASP A 1 1024 ? 155.882 165.289 136.245 1.00 30.56  ? 1369 ASP A CA    1 
ATOM   4884 C  C     . ASP A 1 1024 ? 156.844 164.146 135.956 1.00 36.42  ? 1369 ASP A C     1 
ATOM   4885 O  O     . ASP A 1 1024 ? 158.008 164.223 136.358 1.00 32.93  ? 1369 ASP A O     1 
ATOM   4886 C  CB    . ASP A 1 1024 ? 155.478 165.257 137.718 1.00 27.34  ? 1369 ASP A CB    1 
ATOM   4887 C  CG    . ASP A 1 1024 ? 154.818 166.541 138.166 1.00 51.44  ? 1369 ASP A CG    1 
ATOM   4888 O  OD1   . ASP A 1 1024 ? 154.295 167.273 137.301 1.00 57.78  ? 1369 ASP A OD1   1 
ATOM   4889 O  OD2   . ASP A 1 1024 ? 154.816 166.819 139.382 1.00 55.41  ? 1369 ASP A OD2   1 
ATOM   4890 N  N     . THR A 1 1025 ? 156.396 163.105 135.256 1.00 39.22  ? 1370 THR A N     1 
ATOM   4891 C  CA    . THR A 1 1025 ? 157.182 161.895 135.054 1.00 34.14  ? 1370 THR A CA    1 
ATOM   4892 C  C     . THR A 1 1025 ? 158.038 161.944 133.792 1.00 42.61  ? 1370 THR A C     1 
ATOM   4893 O  O     . THR A 1 1025 ? 159.236 161.656 133.845 1.00 51.75  ? 1370 THR A O     1 
ATOM   4894 C  CB    . THR A 1 1025 ? 156.252 160.679 135.003 1.00 37.98  ? 1370 THR A CB    1 
ATOM   4895 O  OG1   . THR A 1 1025 ? 155.689 160.453 136.300 1.00 43.72  ? 1370 THR A OG1   1 
ATOM   4896 C  CG2   . THR A 1 1025 ? 157.008 159.445 134.566 1.00 39.45  ? 1370 THR A CG2   1 
ATOM   4897 N  N     . MET A 1 1026 ? 157.450 162.303 132.654 1.00 35.85  ? 1371 MET A N     1 
ATOM   4898 C  CA    . MET A 1 1026 ? 158.113 162.158 131.364 1.00 28.67  ? 1371 MET A CA    1 
ATOM   4899 C  C     . MET A 1 1026 ? 157.896 163.373 130.466 1.00 36.98  ? 1371 MET A C     1 
ATOM   4900 O  O     . MET A 1 1026 ? 157.699 163.250 129.254 1.00 50.68  ? 1371 MET A O     1 
ATOM   4901 C  CB    . MET A 1 1026 ? 157.663 160.860 130.696 1.00 42.18  ? 1371 MET A CB    1 
ATOM   4902 C  CG    . MET A 1 1026 ? 156.265 160.864 130.103 1.00 41.60  ? 1371 MET A CG    1 
ATOM   4903 S  SD    . MET A 1 1026 ? 155.546 159.217 130.135 1.00 57.02  ? 1371 MET A SD    1 
ATOM   4904 C  CE    . MET A 1 1026 ? 154.207 159.409 128.974 1.00 41.47  ? 1371 MET A CE    1 
ATOM   4905 N  N     . SER A 1 1027 ? 157.980 164.574 131.031 1.00 26.11  ? 1372 SER A N     1 
ATOM   4906 C  CA    . SER A 1 1027 ? 157.896 165.793 130.235 1.00 25.93  ? 1372 SER A CA    1 
ATOM   4907 C  C     . SER A 1 1027 ? 159.256 166.356 129.851 1.00 42.00  ? 1372 SER A C     1 
ATOM   4908 O  O     . SER A 1 1027 ? 159.311 167.391 129.182 1.00 48.98  ? 1372 SER A O     1 
ATOM   4909 C  CB    . SER A 1 1027 ? 157.107 166.865 130.981 1.00 32.39  ? 1372 SER A CB    1 
ATOM   4910 O  OG    . SER A 1 1027 ? 155.831 166.381 131.347 1.00 51.35  ? 1372 SER A OG    1 
ATOM   4911 N  N     . ASP A 1 1028 ? 160.349 165.712 130.257 1.00 50.85  ? 1373 ASP A N     1 
ATOM   4912 C  CA    . ASP A 1 1028 ? 161.685 166.165 129.903 1.00 47.16  ? 1373 ASP A CA    1 
ATOM   4913 C  C     . ASP A 1 1028 ? 162.390 165.259 128.908 1.00 46.05  ? 1373 ASP A C     1 
ATOM   4914 O  O     . ASP A 1 1028 ? 163.404 165.669 128.337 1.00 50.37  ? 1373 ASP A O     1 
ATOM   4915 C  CB    . ASP A 1 1028 ? 162.558 166.285 131.158 1.00 50.12  ? 1373 ASP A CB    1 
ATOM   4916 C  CG    . ASP A 1 1028 ? 162.691 164.972 131.896 1.00 56.59  ? 1373 ASP A CG    1 
ATOM   4917 O  OD1   . ASP A 1 1028 ? 161.651 164.335 132.155 1.00 59.14  ? 1373 ASP A OD1   1 
ATOM   4918 O  OD2   . ASP A 1 1028 ? 163.829 164.572 132.212 1.00 54.68  ? 1373 ASP A OD2   1 
ATOM   4919 N  N     . LEU A 1 1029 ? 161.891 164.051 128.696 1.00 37.70  ? 1374 LEU A N     1 
ATOM   4920 C  CA    . LEU A 1 1029 ? 162.533 163.131 127.771 1.00 44.27  ? 1374 LEU A CA    1 
ATOM   4921 C  C     . LEU A 1 1029 ? 162.337 163.615 126.339 1.00 49.03  ? 1374 LEU A C     1 
ATOM   4922 O  O     . LEU A 1 1029 ? 161.203 163.896 125.935 1.00 50.41  ? 1374 LEU A O     1 
ATOM   4923 C  CB    . LEU A 1 1029 ? 161.965 161.728 127.946 1.00 43.84  ? 1374 LEU A CB    1 
ATOM   4924 C  CG    . LEU A 1 1029 ? 162.071 161.174 129.365 1.00 28.92  ? 1374 LEU A CG    1 
ATOM   4925 C  CD1   . LEU A 1 1029 ? 161.408 159.824 129.458 1.00 38.50  ? 1374 LEU A CD1   1 
ATOM   4926 C  CD2   . LEU A 1 1029 ? 163.518 161.085 129.794 1.00 41.46  ? 1374 LEU A CD2   1 
ATOM   4927 N  N     . PRO A 1 1030 ? 163.404 163.726 125.549 1.00 46.38  ? 1375 PRO A N     1 
ATOM   4928 C  CA    . PRO A 1 1030 ? 163.266 164.277 124.198 1.00 47.72  ? 1375 PRO A CA    1 
ATOM   4929 C  C     . PRO A 1 1030 ? 162.406 163.391 123.313 1.00 47.75  ? 1375 PRO A C     1 
ATOM   4930 O  O     . PRO A 1 1030 ? 162.298 162.182 123.521 1.00 46.78  ? 1375 PRO A O     1 
ATOM   4931 C  CB    . PRO A 1 1030 ? 164.711 164.340 123.690 1.00 45.68  ? 1375 PRO A CB    1 
ATOM   4932 C  CG    . PRO A 1 1030 ? 165.451 163.364 124.528 1.00 44.29  ? 1375 PRO A CG    1 
ATOM   4933 C  CD    . PRO A 1 1030 ? 164.800 163.396 125.870 1.00 48.32  ? 1375 PRO A CD    1 
ATOM   4934 N  N     . GLU A 1 1031 ? 161.779 164.022 122.323 1.00 60.49  ? 1376 GLU A N     1 
ATOM   4935 C  CA    . GLU A 1 1031 ? 160.898 163.311 121.407 1.00 58.08  ? 1376 GLU A CA    1 
ATOM   4936 C  C     . GLU A 1 1031 ? 161.662 162.232 120.654 1.00 59.99  ? 1376 GLU A C     1 
ATOM   4937 O  O     . GLU A 1 1031 ? 162.754 162.475 120.133 1.00 59.99  ? 1376 GLU A O     1 
ATOM   4938 C  CB    . GLU A 1 1031 ? 160.267 164.296 120.423 1.00 61.72  ? 1376 GLU A CB    1 
ATOM   4939 C  CG    . GLU A 1 1031 ? 159.171 163.700 119.554 1.00 65.13  ? 1376 GLU A CG    1 
ATOM   4940 C  CD    . GLU A 1 1031 ? 158.070 164.694 119.240 1.00 69.64  ? 1376 GLU A CD    1 
ATOM   4941 O  OE1   . GLU A 1 1031 ? 157.682 165.459 120.148 1.00 67.49  ? 1376 GLU A OE1   1 
ATOM   4942 O  OE2   . GLU A 1 1031 ? 157.594 164.712 118.086 1.00 68.71  ? 1376 GLU A OE2   1 
ATOM   4943 N  N     . VAL A 1 1032 ? 161.081 161.036 120.598 1.00 59.86  ? 1377 VAL A N     1 
ATOM   4944 C  CA    . VAL A 1 1032 ? 161.665 159.915 119.878 1.00 60.59  ? 1377 VAL A CA    1 
ATOM   4945 C  C     . VAL A 1 1032 ? 160.598 159.339 118.959 1.00 63.13  ? 1377 VAL A C     1 
ATOM   4946 O  O     . VAL A 1 1032 ? 159.397 159.519 119.170 1.00 68.24  ? 1377 VAL A O     1 
ATOM   4947 C  CB    . VAL A 1 1032 ? 162.220 158.829 120.826 1.00 55.80  ? 1377 VAL A CB    1 
ATOM   4948 C  CG1   . VAL A 1 1032 ? 161.130 157.853 121.234 1.00 49.95  ? 1377 VAL A CG1   1 
ATOM   4949 C  CG2   . VAL A 1 1032 ? 163.385 158.108 120.183 1.00 64.04  ? 1377 VAL A CG2   1 
ATOM   4950 N  N     . ARG A 1 1033 ? 161.052 158.651 117.921 1.00 71.98  ? 1378 ARG A N     1 
ATOM   4951 C  CA    . ARG A 1 1033 ? 160.154 158.114 116.913 1.00 74.64  ? 1378 ARG A CA    1 
ATOM   4952 C  C     . ARG A 1 1033 ? 159.813 156.660 117.225 1.00 74.55  ? 1378 ARG A C     1 
ATOM   4953 O  O     . ARG A 1 1033 ? 160.410 156.025 118.096 1.00 80.57  ? 1378 ARG A O     1 
ATOM   4954 C  CB    . ARG A 1 1033 ? 160.768 158.235 115.513 1.00 76.27  ? 1378 ARG A CB    1 
ATOM   4955 C  CG    . ARG A 1 1033 ? 161.052 159.665 115.021 1.00 76.12  ? 1378 ARG A CG    1 
ATOM   4956 C  CD    . ARG A 1 1033 ? 162.248 160.320 115.705 1.00 77.12  ? 1378 ARG A CD    1 
ATOM   4957 N  NE    . ARG A 1 1033 ? 162.168 161.776 115.684 1.00 85.08  ? 1378 ARG A NE    1 
ATOM   4958 C  CZ    . ARG A 1 1033 ? 163.065 162.584 116.235 1.00 81.29  ? 1378 ARG A CZ    1 
ATOM   4959 N  NH1   . ARG A 1 1033 ? 164.126 162.111 116.869 1.00 76.89  ? 1378 ARG A NH1   1 
ATOM   4960 N  NH2   . ARG A 1 1033 ? 162.891 163.900 116.151 1.00 76.36  ? 1378 ARG A NH2   1 
ATOM   4961 N  N     . ASN A 1 1034 ? 158.826 156.135 116.504 1.00 68.92  ? 1379 ASN A N     1 
ATOM   4962 C  CA    . ASN A 1 1034 ? 158.426 154.748 116.686 1.00 70.62  ? 1379 ASN A CA    1 
ATOM   4963 C  C     . ASN A 1 1034 ? 159.551 153.810 116.272 1.00 73.83  ? 1379 ASN A C     1 
ATOM   4964 O  O     . ASN A 1 1034 ? 160.278 154.071 115.310 1.00 78.28  ? 1379 ASN A O     1 
ATOM   4965 C  CB    . ASN A 1 1034 ? 157.167 154.445 115.877 1.00 75.08  ? 1379 ASN A CB    1 
ATOM   4966 C  CG    . ASN A 1 1034 ? 156.696 153.015 116.047 1.00 74.16  ? 1379 ASN A CG    1 
ATOM   4967 O  OD1   . ASN A 1 1034 ? 156.280 152.613 117.132 1.00 76.22  ? 1379 ASN A OD1   1 
ATOM   4968 N  ND2   . ASN A 1 1034 ? 156.756 152.240 114.972 1.00 70.58  ? 1379 ASN A ND2   1 
ATOM   4969 N  N     . GLY A 1 1035 ? 159.689 152.710 117.003 1.00 73.87  ? 1380 GLY A N     1 
ATOM   4970 C  CA    . GLY A 1 1035 ? 160.736 151.746 116.716 1.00 77.28  ? 1380 GLY A CA    1 
ATOM   4971 C  C     . GLY A 1 1035 ? 162.137 152.262 116.960 1.00 79.13  ? 1380 GLY A C     1 
ATOM   4972 O  O     . GLY A 1 1035 ? 163.047 151.970 116.174 1.00 76.45  ? 1380 GLY A O     1 
ATOM   4973 N  N     . ALA A 1 1036 ? 162.333 153.026 118.030 1.00 78.53  ? 1381 ALA A N     1 
ATOM   4974 C  CA    . ALA A 1 1036 ? 163.651 153.555 118.341 1.00 77.47  ? 1381 ALA A CA    1 
ATOM   4975 C  C     . ALA A 1 1036 ? 164.584 152.442 118.802 1.00 85.16  ? 1381 ALA A C     1 
ATOM   4976 O  O     . ALA A 1 1036 ? 164.157 151.439 119.378 1.00 86.85  ? 1381 ALA A O     1 
ATOM   4977 C  CB    . ALA A 1 1036 ? 163.552 154.632 119.416 1.00 72.91  ? 1381 ALA A CB    1 
ATOM   4978 N  N     . SER A 1 1037 ? 165.877 152.628 118.536 1.00 88.63  ? 1382 SER A N     1 
ATOM   4979 C  CA    . SER A 1 1037 ? 166.882 151.659 118.954 1.00 84.57  ? 1382 SER A CA    1 
ATOM   4980 C  C     . SER A 1 1037 ? 168.124 152.274 119.578 1.00 84.48  ? 1382 SER A C     1 
ATOM   4981 O  O     . SER A 1 1037 ? 168.926 151.526 120.144 1.00 86.80  ? 1382 SER A O     1 
ATOM   4982 C  CB    . SER A 1 1037 ? 167.308 150.785 117.765 1.00 85.38  ? 1382 SER A CB    1 
ATOM   4983 O  OG    . SER A 1 1037 ? 166.246 149.946 117.347 1.00 84.34  ? 1382 SER A OG    1 
ATOM   4984 N  N     . ALA A 1 1038 ? 168.321 153.587 119.499 1.00 73.98  ? 1383 ALA A N     1 
ATOM   4985 C  CA    . ALA A 1 1038 ? 169.488 154.204 120.111 1.00 73.46  ? 1383 ALA A CA    1 
ATOM   4986 C  C     . ALA A 1 1038 ? 169.412 154.093 121.628 1.00 75.27  ? 1383 ALA A C     1 
ATOM   4987 O  O     . ALA A 1 1038 ? 168.350 154.278 122.227 1.00 77.29  ? 1383 ALA A O     1 
ATOM   4988 C  CB    . ALA A 1 1038 ? 169.595 155.669 119.695 1.00 72.09  ? 1383 ALA A CB    1 
ATOM   4989 N  N     . LEU A 1 1039 ? 170.550 153.791 122.251 1.00 74.20  ? 1384 LEU A N     1 
ATOM   4990 C  CA    . LEU A 1 1039 ? 170.610 153.580 123.693 1.00 69.76  ? 1384 LEU A CA    1 
ATOM   4991 C  C     . LEU A 1 1039 ? 171.058 154.822 124.452 1.00 68.97  ? 1384 LEU A C     1 
ATOM   4992 O  O     . LEU A 1 1039 ? 170.395 155.236 125.405 1.00 67.94  ? 1384 LEU A O     1 
ATOM   4993 C  CB    . LEU A 1 1039 ? 171.543 152.409 124.015 1.00 68.49  ? 1384 LEU A CB    1 
ATOM   4994 C  CG    . LEU A 1 1039 ? 171.012 151.034 123.614 1.00 69.90  ? 1384 LEU A CG    1 
ATOM   4995 C  CD1   . LEU A 1 1039 ? 171.986 149.942 124.016 1.00 70.65  ? 1384 LEU A CD1   1 
ATOM   4996 C  CD2   . LEU A 1 1039 ? 169.649 150.792 124.232 1.00 68.02  ? 1384 LEU A CD2   1 
ATOM   4997 N  N     . GLU A 1 1040 ? 172.171 155.426 124.051 1.00 78.99  ? 1385 GLU A N     1 
ATOM   4998 C  CA    . GLU A 1 1040 ? 172.722 156.589 124.737 1.00 77.74  ? 1385 GLU A CA    1 
ATOM   4999 C  C     . GLU A 1 1040 ? 172.383 157.841 123.937 1.00 78.21  ? 1385 GLU A C     1 
ATOM   5000 O  O     . GLU A 1 1040 ? 172.966 158.087 122.877 1.00 84.03  ? 1385 GLU A O     1 
ATOM   5001 C  CB    . GLU A 1 1040 ? 174.231 156.444 124.918 1.00 81.33  ? 1385 GLU A CB    1 
ATOM   5002 C  CG    . GLU A 1 1040 ? 174.665 155.059 125.361 1.00 83.69  ? 1385 GLU A CG    1 
ATOM   5003 C  CD    . GLU A 1 1040 ? 176.014 155.064 126.052 1.00 87.05  ? 1385 GLU A CD    1 
ATOM   5004 O  OE1   . GLU A 1 1040 ? 177.003 155.497 125.425 1.00 84.38  ? 1385 GLU A OE1   1 
ATOM   5005 O  OE2   . GLU A 1 1040 ? 176.085 154.633 127.222 1.00 84.11  ? 1385 GLU A OE2   1 
ATOM   5006 N  N     . ILE A 1 1041 ? 171.441 158.631 124.450 1.00 67.27  ? 1386 ILE A N     1 
ATOM   5007 C  CA    . ILE A 1 1041 ? 171.072 159.904 123.841 1.00 70.94  ? 1386 ILE A CA    1 
ATOM   5008 C  C     . ILE A 1 1041 ? 171.462 161.015 124.806 1.00 72.08  ? 1386 ILE A C     1 
ATOM   5009 O  O     . ILE A 1 1041 ? 171.955 160.747 125.906 1.00 75.09  ? 1386 ILE A O     1 
ATOM   5010 C  CB    . ILE A 1 1041 ? 169.572 159.954 123.498 1.00 73.31  ? 1386 ILE A CB    1 
ATOM   5011 C  CG1   . ILE A 1 1041 ? 169.052 158.557 123.166 1.00 72.41  ? 1386 ILE A CG1   1 
ATOM   5012 C  CG2   . ILE A 1 1041 ? 169.323 160.866 122.313 1.00 76.74  ? 1386 ILE A CG2   1 
ATOM   5013 C  CD1   . ILE A 1 1041 ? 167.550 158.489 123.031 1.00 68.91  ? 1386 ILE A CD1   1 
ATOM   5014 N  N     . SER A 1 1042 ? 171.252 162.265 124.408 1.00 71.72  ? 1387 SER A N     1 
ATOM   5015 C  CA    . SER A 1 1042 ? 171.605 163.415 125.226 1.00 74.86  ? 1387 SER A CA    1 
ATOM   5016 C  C     . SER A 1 1042 ? 170.349 164.169 125.636 1.00 76.47  ? 1387 SER A C     1 
ATOM   5017 O  O     . SER A 1 1042 ? 169.417 164.322 124.841 1.00 75.57  ? 1387 SER A O     1 
ATOM   5018 C  CB    . SER A 1 1042 ? 172.552 164.355 124.479 1.00 78.45  ? 1387 SER A CB    1 
ATOM   5019 O  OG    . SER A 1 1042 ? 172.754 165.555 125.205 1.00 80.70  ? 1387 SER A OG    1 
ATOM   5020 N  N     . TYR A 1 1043 ? 170.328 164.631 126.884 1.00 78.40  ? 1388 TYR A N     1 
ATOM   5021 C  CA    . TYR A 1 1043 ? 169.229 165.463 127.353 1.00 78.91  ? 1388 TYR A CA    1 
ATOM   5022 C  C     . TYR A 1 1043 ? 169.186 166.776 126.586 1.00 79.29  ? 1388 TYR A C     1 
ATOM   5023 O  O     . TYR A 1 1043 ? 170.217 167.409 126.345 1.00 82.51  ? 1388 TYR A O     1 
ATOM   5024 C  CB    . TYR A 1 1043 ? 169.372 165.748 128.847 1.00 78.44  ? 1388 TYR A CB    1 
ATOM   5025 C  CG    . TYR A 1 1043 ? 169.075 164.569 129.735 1.00 75.26  ? 1388 TYR A CG    1 
ATOM   5026 C  CD1   . TYR A 1 1043 ? 167.833 163.961 129.712 1.00 72.13  ? 1388 TYR A CD1   1 
ATOM   5027 C  CD2   . TYR A 1 1043 ? 170.035 164.069 130.600 1.00 75.28  ? 1388 TYR A CD2   1 
ATOM   5028 C  CE1   . TYR A 1 1043 ? 167.554 162.890 130.523 1.00 74.85  ? 1388 TYR A CE1   1 
ATOM   5029 C  CE2   . TYR A 1 1043 ? 169.766 162.993 131.414 1.00 76.12  ? 1388 TYR A CE2   1 
ATOM   5030 C  CZ    . TYR A 1 1043 ? 168.524 162.405 131.370 1.00 76.11  ? 1388 TYR A CZ    1 
ATOM   5031 O  OH    . TYR A 1 1043 ? 168.253 161.330 132.183 1.00 75.48  ? 1388 TYR A OH    1 
ATOM   5032 N  N     . ASN A 1 1044 ? 167.982 167.185 126.204 1.00 83.52  ? 1389 ASN A N     1 
ATOM   5033 C  CA    . ASN A 1 1044 ? 167.782 168.467 125.548 1.00 85.52  ? 1389 ASN A CA    1 
ATOM   5034 C  C     . ASN A 1 1044 ? 167.418 169.578 126.524 1.00 90.35  ? 1389 ASN A C     1 
ATOM   5035 O  O     . ASN A 1 1044 ? 167.242 170.723 126.097 1.00 90.47  ? 1389 ASN A O     1 
ATOM   5036 C  CB    . ASN A 1 1044 ? 166.699 168.344 124.473 1.00 85.18  ? 1389 ASN A CB    1 
ATOM   5037 C  CG    . ASN A 1 1044 ? 167.254 167.877 123.144 1.00 87.93  ? 1389 ASN A CG    1 
ATOM   5038 O  OD1   . ASN A 1 1044 ? 168.162 167.048 123.094 1.00 89.47  ? 1389 ASN A OD1   1 
ATOM   5039 N  ND2   . ASN A 1 1044 ? 166.710 168.410 122.056 1.00 88.60  ? 1389 ASN A ND2   1 
ATOM   5040 N  N     . GLY A 1 1045 ? 167.304 169.273 127.812 1.00 86.39  ? 1390 GLY A N     1 
ATOM   5041 C  CA    . GLY A 1 1045 ? 166.955 170.293 128.785 1.00 82.93  ? 1390 GLY A CA    1 
ATOM   5042 C  C     . GLY A 1 1045 ? 167.087 169.770 130.197 1.00 79.45  ? 1390 GLY A C     1 
ATOM   5043 O  O     . GLY A 1 1045 ? 167.208 168.565 130.433 1.00 78.14  ? 1390 GLY A O     1 
ATOM   5044 N  N     . GLU A 1 1046 ? 167.054 170.708 131.137 1.00 80.17  ? 1391 GLU A N     1 
ATOM   5045 C  CA    . GLU A 1 1046 ? 167.149 170.384 132.547 1.00 79.95  ? 1391 GLU A CA    1 
ATOM   5046 C  C     . GLU A 1 1046 ? 165.849 169.743 133.031 1.00 79.58  ? 1391 GLU A C     1 
ATOM   5047 O  O     . GLU A 1 1046 ? 164.821 169.824 132.356 1.00 83.36  ? 1391 GLU A O     1 
ATOM   5048 C  CB    . GLU A 1 1046 ? 167.455 171.645 133.352 1.00 80.85  ? 1391 GLU A CB    1 
ATOM   5049 C  CG    . GLU A 1 1046 ? 168.866 172.170 133.161 1.00 84.03  ? 1391 GLU A CG    1 
ATOM   5050 C  CD    . GLU A 1 1046 ? 169.781 171.815 134.314 1.00 84.88  ? 1391 GLU A CD    1 
ATOM   5051 O  OE1   . GLU A 1 1046 ? 169.339 171.080 135.221 1.00 84.75  ? 1391 GLU A OE1   1 
ATOM   5052 O  OE2   . GLU A 1 1046 ? 170.944 172.270 134.313 1.00 85.53  ? 1391 GLU A OE2   1 
ATOM   5053 N  N     . PRO A 1 1047 ? 165.876 169.075 134.186 1.00 64.40  ? 1392 PRO A N     1 
ATOM   5054 C  CA    . PRO A 1 1047 ? 164.635 168.519 134.738 1.00 65.02  ? 1392 PRO A CA    1 
ATOM   5055 C  C     . PRO A 1 1047 ? 163.596 169.606 134.965 1.00 65.02  ? 1392 PRO A C     1 
ATOM   5056 O  O     . PRO A 1 1047 ? 163.918 170.726 135.365 1.00 65.67  ? 1392 PRO A O     1 
ATOM   5057 C  CB    . PRO A 1 1047 ? 165.083 167.882 136.059 1.00 63.24  ? 1392 PRO A CB    1 
ATOM   5058 C  CG    . PRO A 1 1047 ? 166.465 168.401 136.312 1.00 64.76  ? 1392 PRO A CG    1 
ATOM   5059 C  CD    . PRO A 1 1047 ? 167.050 168.672 134.975 1.00 65.21  ? 1392 PRO A CD    1 
ATOM   5060 N  N     . GLN A 1 1048 ? 162.334 169.260 134.707 1.00 55.95  ? 1393 GLN A N     1 
ATOM   5061 C  CA    . GLN A 1 1048 ? 161.244 170.228 134.709 1.00 50.22  ? 1393 GLN A CA    1 
ATOM   5062 C  C     . GLN A 1 1048 ? 160.178 169.911 135.750 1.00 49.91  ? 1393 GLN A C     1 
ATOM   5063 O  O     . GLN A 1 1048 ? 159.013 170.268 135.560 1.00 57.89  ? 1393 GLN A O     1 
ATOM   5064 C  CB    . GLN A 1 1048 ? 160.605 170.310 133.322 1.00 49.32  ? 1393 GLN A CB    1 
ATOM   5065 C  CG    . GLN A 1 1048 ? 161.580 170.613 132.206 1.00 55.23  ? 1393 GLN A CG    1 
ATOM   5066 C  CD    . GLN A 1 1048 ? 160.916 170.610 130.850 1.00 59.40  ? 1393 GLN A CD    1 
ATOM   5067 O  OE1   . GLN A 1 1048 ? 159.690 170.605 130.748 1.00 64.52  ? 1393 GLN A OE1   1 
ATOM   5068 N  NE2   . GLN A 1 1048 ? 161.721 170.613 129.796 1.00 58.66  ? 1393 GLN A NE2   1 
ATOM   5069 N  N     . SER A 1 1049 ? 160.546 169.251 136.842 1.00 38.17  ? 1394 SER A N     1 
ATOM   5070 C  CA    . SER A 1 1049 ? 159.603 168.958 137.914 1.00 37.13  ? 1394 SER A CA    1 
ATOM   5071 C  C     . SER A 1 1049 ? 160.394 168.497 139.127 1.00 41.57  ? 1394 SER A C     1 
ATOM   5072 O  O     . SER A 1 1049 ? 161.624 168.420 139.097 1.00 49.91  ? 1394 SER A O     1 
ATOM   5073 C  CB    . SER A 1 1049 ? 158.582 167.900 137.501 1.00 47.19  ? 1394 SER A CB    1 
ATOM   5074 O  OG    . SER A 1 1049 ? 159.087 166.598 137.727 1.00 52.22  ? 1394 SER A OG    1 
ATOM   5075 N  N     . TRP A 1 1050 ? 159.671 168.202 140.207 1.00 45.42  ? 1395 TRP A N     1 
ATOM   5076 C  CA    . TRP A 1 1050 ? 160.325 167.649 141.387 1.00 50.84  ? 1395 TRP A CA    1 
ATOM   5077 C  C     . TRP A 1 1050 ? 160.689 166.186 141.177 1.00 52.14  ? 1395 TRP A C     1 
ATOM   5078 O  O     . TRP A 1 1050 ? 161.756 165.740 141.609 1.00 57.90  ? 1395 TRP A O     1 
ATOM   5079 C  CB    . TRP A 1 1050 ? 159.431 167.803 142.613 1.00 39.13  ? 1395 TRP A CB    1 
ATOM   5080 C  CG    . TRP A 1 1050 ? 159.995 167.160 143.839 1.00 39.35  ? 1395 TRP A CG    1 
ATOM   5081 C  CD1   . TRP A 1 1050 ? 160.891 167.703 144.708 1.00 42.06  ? 1395 TRP A CD1   1 
ATOM   5082 C  CD2   . TRP A 1 1050 ? 159.702 165.847 144.331 1.00 45.69  ? 1395 TRP A CD2   1 
ATOM   5083 N  NE1   . TRP A 1 1050 ? 161.172 166.813 145.714 1.00 47.38  ? 1395 TRP A NE1   1 
ATOM   5084 C  CE2   . TRP A 1 1050 ? 160.454 165.666 145.505 1.00 46.40  ? 1395 TRP A CE2   1 
ATOM   5085 C  CE3   . TRP A 1 1050 ? 158.875 164.810 143.894 1.00 44.15  ? 1395 TRP A CE3   1 
ATOM   5086 C  CZ2   . TRP A 1 1050 ? 160.405 164.491 146.245 1.00 45.99  ? 1395 TRP A CZ2   1 
ATOM   5087 C  CZ3   . TRP A 1 1050 ? 158.827 163.645 144.631 1.00 37.95  ? 1395 TRP A CZ3   1 
ATOM   5088 C  CH2   . TRP A 1 1050 ? 159.587 163.494 145.792 1.00 36.92  ? 1395 TRP A CH2   1 
ATOM   5089 N  N     . PHE A 1 1051 ? 159.812 165.426 140.520 1.00 31.34  ? 1396 PHE A N     1 
ATOM   5090 C  CA    . PHE A 1 1051 ? 160.082 164.012 140.289 1.00 21.59  ? 1396 PHE A CA    1 
ATOM   5091 C  C     . PHE A 1 1051 ? 161.342 163.826 139.454 1.00 42.58  ? 1396 PHE A C     1 
ATOM   5092 O  O     . PHE A 1 1051 ? 162.213 163.016 139.793 1.00 57.72  ? 1396 PHE A O     1 
ATOM   5093 C  CB    . PHE A 1 1051 ? 158.880 163.367 139.605 1.00 32.70  ? 1396 PHE A CB    1 
ATOM   5094 C  CG    . PHE A 1 1051 ? 158.816 161.877 139.762 1.00 41.42  ? 1396 PHE A CG    1 
ATOM   5095 C  CD1   . PHE A 1 1051 ? 158.851 161.297 141.013 1.00 50.53  ? 1396 PHE A CD1   1 
ATOM   5096 C  CD2   . PHE A 1 1051 ? 158.700 161.058 138.657 1.00 40.68  ? 1396 PHE A CD2   1 
ATOM   5097 C  CE1   . PHE A 1 1051 ? 158.784 159.929 141.156 1.00 40.72  ? 1396 PHE A CE1   1 
ATOM   5098 C  CE2   . PHE A 1 1051 ? 158.631 159.694 138.798 1.00 37.16  ? 1396 PHE A CE2   1 
ATOM   5099 C  CZ    . PHE A 1 1051 ? 158.673 159.129 140.046 1.00 27.05  ? 1396 PHE A CZ    1 
ATOM   5100 N  N     . GLN A 1 1052 ? 161.467 164.588 138.367 1.00 48.26  ? 1397 GLN A N     1 
ATOM   5101 C  CA    . GLN A 1 1052 ? 162.638 164.457 137.507 1.00 41.62  ? 1397 GLN A CA    1 
ATOM   5102 C  C     . GLN A 1 1052 ? 163.895 164.966 138.198 1.00 43.14  ? 1397 GLN A C     1 
ATOM   5103 O  O     . GLN A 1 1052 ? 164.965 164.364 138.069 1.00 49.78  ? 1397 GLN A O     1 
ATOM   5104 C  CB    . GLN A 1 1052 ? 162.407 165.195 136.193 1.00 41.44  ? 1397 GLN A CB    1 
ATOM   5105 C  CG    . GLN A 1 1052 ? 161.426 164.491 135.285 1.00 40.71  ? 1397 GLN A CG    1 
ATOM   5106 C  CD    . GLN A 1 1052 ? 160.409 165.431 134.693 1.00 44.15  ? 1397 GLN A CD    1 
ATOM   5107 O  OE1   . GLN A 1 1052 ? 160.519 166.647 134.827 1.00 54.97  ? 1397 GLN A OE1   1 
ATOM   5108 N  NE2   . GLN A 1 1052 ? 159.404 164.872 134.036 1.00 45.91  ? 1397 GLN A NE2   1 
ATOM   5109 N  N     . ARG A 1 1053 ? 163.789 166.070 138.939 1.00 44.31  ? 1398 ARG A N     1 
ATOM   5110 C  CA    . ARG A 1 1053 ? 164.947 166.573 139.667 1.00 47.89  ? 1398 ARG A CA    1 
ATOM   5111 C  C     . ARG A 1 1053 ? 165.433 165.558 140.690 1.00 49.88  ? 1398 ARG A C     1 
ATOM   5112 O  O     . ARG A 1 1053 ? 166.641 165.401 140.897 1.00 49.77  ? 1398 ARG A O     1 
ATOM   5113 C  CB    . ARG A 1 1053 ? 164.609 167.895 140.351 1.00 45.97  ? 1398 ARG A CB    1 
ATOM   5114 C  CG    . ARG A 1 1053 ? 165.055 169.123 139.586 1.00 51.38  ? 1398 ARG A CG    1 
ATOM   5115 C  CD    . ARG A 1 1053 ? 164.860 170.376 140.416 1.00 50.24  ? 1398 ARG A CD    1 
ATOM   5116 N  NE    . ARG A 1 1053 ? 163.553 170.974 140.181 1.00 52.08  ? 1398 ARG A NE    1 
ATOM   5117 C  CZ    . ARG A 1 1053 ? 162.503 170.801 140.970 1.00 46.96  ? 1398 ARG A CZ    1 
ATOM   5118 N  NH1   . ARG A 1 1053 ? 162.571 170.047 142.053 1.00 47.22  ? 1398 ARG A NH1   1 
ATOM   5119 N  NH2   . ARG A 1 1053 ? 161.357 171.400 140.664 1.00 51.11  ? 1398 ARG A NH2   1 
ATOM   5120 N  N     . GLN A 1 1054 ? 164.502 164.865 141.348 1.00 42.91  ? 1399 GLN A N     1 
ATOM   5121 C  CA    . GLN A 1 1054 ? 164.885 163.856 142.327 1.00 37.68  ? 1399 GLN A CA    1 
ATOM   5122 C  C     . GLN A 1 1054 ? 165.497 162.634 141.657 1.00 51.79  ? 1399 GLN A C     1 
ATOM   5123 O  O     . GLN A 1 1054 ? 166.485 162.080 142.152 1.00 63.44  ? 1399 GLN A O     1 
ATOM   5124 C  CB    . GLN A 1 1054 ? 163.673 163.459 143.168 1.00 37.64  ? 1399 GLN A CB    1 
ATOM   5125 C  CG    . GLN A 1 1054 ? 163.994 163.172 144.623 1.00 48.18  ? 1399 GLN A CG    1 
ATOM   5126 C  CD    . GLN A 1 1054 ? 164.344 164.422 145.412 1.00 58.00  ? 1399 GLN A CD    1 
ATOM   5127 O  OE1   . GLN A 1 1054 ? 164.267 165.539 144.901 1.00 54.96  ? 1399 GLN A OE1   1 
ATOM   5128 N  NE2   . GLN A 1 1054 ? 164.730 164.237 146.668 1.00 59.11  ? 1399 GLN A NE2   1 
ATOM   5129 N  N     . LEU A 1 1055 ? 164.926 162.194 140.535 1.00 46.13  ? 1400 LEU A N     1 
ATOM   5130 C  CA    . LEU A 1 1055 ? 165.430 160.990 139.884 1.00 32.73  ? 1400 LEU A CA    1 
ATOM   5131 C  C     . LEU A 1 1055 ? 166.807 161.221 139.271 1.00 37.27  ? 1400 LEU A C     1 
ATOM   5132 O  O     . LEU A 1 1055 ? 167.729 160.425 139.480 1.00 37.05  ? 1400 LEU A O     1 
ATOM   5133 C  CB    . LEU A 1 1055 ? 164.441 160.518 138.824 1.00 31.84  ? 1400 LEU A CB    1 
ATOM   5134 C  CG    . LEU A 1 1055 ? 163.150 159.926 139.380 1.00 30.80  ? 1400 LEU A CG    1 
ATOM   5135 C  CD1   . LEU A 1 1055 ? 162.113 159.815 138.285 1.00 28.86  ? 1400 LEU A CD1   1 
ATOM   5136 C  CD2   . LEU A 1 1055 ? 163.407 158.580 140.015 1.00 34.78  ? 1400 LEU A CD2   1 
ATOM   5137 N  N     . ARG A 1 1056 ? 166.968 162.306 138.510 1.00 57.48  ? 1401 ARG A N     1 
ATOM   5138 C  CA    . ARG A 1 1056 ? 168.242 162.555 137.842 1.00 62.95  ? 1401 ARG A CA    1 
ATOM   5139 C  C     . ARG A 1 1056 ? 169.352 162.847 138.843 1.00 64.18  ? 1401 ARG A C     1 
ATOM   5140 O  O     . ARG A 1 1056 ? 170.480 162.371 138.684 1.00 61.61  ? 1401 ARG A O     1 
ATOM   5141 C  CB    . ARG A 1 1056 ? 168.100 163.709 136.851 1.00 62.27  ? 1401 ARG A CB    1 
ATOM   5142 C  CG    . ARG A 1 1056 ? 166.951 163.547 135.873 1.00 60.60  ? 1401 ARG A CG    1 
ATOM   5143 C  CD    . ARG A 1 1056 ? 167.445 163.364 134.460 1.00 62.41  ? 1401 ARG A CD    1 
ATOM   5144 N  NE    . ARG A 1 1056 ? 167.904 164.616 133.872 1.00 66.43  ? 1401 ARG A NE    1 
ATOM   5145 C  CZ    . ARG A 1 1056 ? 167.181 165.361 133.048 1.00 65.11  ? 1401 ARG A CZ    1 
ATOM   5146 N  NH1   . ARG A 1 1056 ? 165.954 165.014 132.700 1.00 60.53  ? 1401 ARG A NH1   1 
ATOM   5147 N  NH2   . ARG A 1 1056 ? 167.704 166.481 132.559 1.00 67.83  ? 1401 ARG A NH2   1 
ATOM   5148 N  N     . GLY A 1 1057 ? 169.053 163.625 139.876 1.00 77.61  ? 1402 GLY A N     1 
ATOM   5149 C  CA    . GLY A 1 1057 ? 170.045 164.016 140.852 1.00 76.59  ? 1402 GLY A CA    1 
ATOM   5150 C  C     . GLY A 1 1057 ? 170.773 165.289 140.462 1.00 79.48  ? 1402 GLY A C     1 
ATOM   5151 O  O     . GLY A 1 1057 ? 170.664 165.800 139.345 1.00 76.95  ? 1402 GLY A O     1 
ATOM   5152 N  N     . ALA A 1 1058 ? 171.539 165.810 141.420 1.00 96.17  ? 1403 ALA A N     1 
ATOM   5153 C  CA    . ALA A 1 1058 ? 172.286 167.043 141.211 1.00 95.06  ? 1403 ALA A CA    1 
ATOM   5154 C  C     . ALA A 1 1058 ? 173.583 166.831 140.444 1.00 95.71  ? 1403 ALA A C     1 
ATOM   5155 O  O     . ALA A 1 1058 ? 174.228 167.816 140.069 1.00 94.15  ? 1403 ALA A O     1 
ATOM   5156 C  CB    . ALA A 1 1058 ? 172.590 167.709 142.555 1.00 91.70  ? 1403 ALA A CB    1 
ATOM   5157 N  N     . GLN A 1 1059 ? 173.982 165.584 140.206 1.00 98.78  ? 1404 GLN A N     1 
ATOM   5158 C  CA    . GLN A 1 1059 ? 175.198 165.320 139.453 1.00 97.60  ? 1404 GLN A CA    1 
ATOM   5159 C  C     . GLN A 1 1059 ? 175.021 165.725 137.994 1.00 96.52  ? 1404 GLN A C     1 
ATOM   5160 O  O     . GLN A 1 1059 ? 173.910 165.746 137.460 1.00 95.26  ? 1404 GLN A O     1 
ATOM   5161 C  CB    . GLN A 1 1059 ? 175.579 163.843 139.548 1.00 96.89  ? 1404 GLN A CB    1 
ATOM   5162 C  CG    . GLN A 1 1059 ? 174.644 162.907 138.801 1.00 92.36  ? 1404 GLN A CG    1 
ATOM   5163 C  CD    . GLN A 1 1059 ? 173.747 162.117 139.730 1.00 94.73  ? 1404 GLN A CD    1 
ATOM   5164 O  OE1   . GLN A 1 1059 ? 172.931 162.684 140.455 1.00 94.66  ? 1404 GLN A OE1   1 
ATOM   5165 N  NE2   . GLN A 1 1059 ? 173.895 160.798 139.715 1.00 95.81  ? 1404 GLN A NE2   1 
ATOM   5166 N  N     . TYR A 1 1060 ? 176.138 166.060 137.352 1.00 110.09 ? 1405 TYR A N     1 
ATOM   5167 C  CA    . TYR A 1 1060 ? 176.132 166.517 135.963 1.00 111.00 ? 1405 TYR A CA    1 
ATOM   5168 C  C     . TYR A 1 1060 ? 176.313 165.310 135.052 1.00 113.44 ? 1405 TYR A C     1 
ATOM   5169 O  O     . TYR A 1 1060 ? 177.425 164.969 134.646 1.00 113.78 ? 1405 TYR A O     1 
ATOM   5170 C  CB    . TYR A 1 1060 ? 177.219 167.560 135.737 1.00 109.12 ? 1405 TYR A CB    1 
ATOM   5171 C  CG    . TYR A 1 1060 ? 177.262 168.098 134.326 1.00 112.71 ? 1405 TYR A CG    1 
ATOM   5172 C  CD1   . TYR A 1 1060 ? 176.303 168.995 133.876 1.00 113.93 ? 1405 TYR A CD1   1 
ATOM   5173 C  CD2   . TYR A 1 1060 ? 178.261 167.710 133.445 1.00 112.40 ? 1405 TYR A CD2   1 
ATOM   5174 C  CE1   . TYR A 1 1060 ? 176.338 169.490 132.587 1.00 114.06 ? 1405 TYR A CE1   1 
ATOM   5175 C  CE2   . TYR A 1 1060 ? 178.305 168.198 132.154 1.00 111.43 ? 1405 TYR A CE2   1 
ATOM   5176 C  CZ    . TYR A 1 1060 ? 177.341 169.088 131.730 1.00 112.80 ? 1405 TYR A CZ    1 
ATOM   5177 O  OH    . TYR A 1 1060 ? 177.381 169.578 130.445 1.00 111.13 ? 1405 TYR A OH    1 
ATOM   5178 N  N     . GLN A 1 1061 ? 175.207 164.649 134.731 1.00 99.84  ? 1406 GLN A N     1 
ATOM   5179 C  CA    . GLN A 1 1061 ? 175.215 163.538 133.780 1.00 95.18  ? 1406 GLN A CA    1 
ATOM   5180 C  C     . GLN A 1 1061 ? 174.363 163.898 132.573 1.00 94.37  ? 1406 GLN A C     1 
ATOM   5181 O  O     . GLN A 1 1061 ? 173.122 163.932 132.679 1.00 92.61  ? 1406 GLN A O     1 
ATOM   5182 C  CB    . GLN A 1 1061 ? 174.714 162.246 134.426 1.00 94.66  ? 1406 GLN A CB    1 
ATOM   5183 C  CG    . GLN A 1 1061 ? 173.508 162.405 135.333 1.00 97.92  ? 1406 GLN A CG    1 
ATOM   5184 C  CD    . GLN A 1 1061 ? 172.891 161.073 135.705 1.00 96.63  ? 1406 GLN A CD    1 
ATOM   5185 O  OE1   . GLN A 1 1061 ? 173.583 160.061 135.796 1.00 96.28  ? 1406 GLN A OE1   1 
ATOM   5186 N  NE2   . GLN A 1 1061 ? 171.581 161.066 135.915 1.00 94.02  ? 1406 GLN A NE2   1 
ATOM   5187 N  N     . PRO A 1 1062 ? 174.963 164.191 131.422 1.00 93.99  ? 1407 PRO A N     1 
ATOM   5188 C  CA    . PRO A 1 1062 ? 174.186 164.530 130.222 1.00 93.14  ? 1407 PRO A CA    1 
ATOM   5189 C  C     . PRO A 1 1062 ? 173.805 163.348 129.342 1.00 89.48  ? 1407 PRO A C     1 
ATOM   5190 O  O     . PRO A 1 1062 ? 173.445 163.568 128.182 1.00 85.37  ? 1407 PRO A O     1 
ATOM   5191 C  CB    . PRO A 1 1062 ? 175.145 165.463 129.471 1.00 90.42  ? 1407 PRO A CB    1 
ATOM   5192 C  CG    . PRO A 1 1062 ? 176.517 164.987 129.859 1.00 89.94  ? 1407 PRO A CG    1 
ATOM   5193 C  CD    . PRO A 1 1062 ? 176.413 164.249 131.174 1.00 89.53  ? 1407 PRO A CD    1 
ATOM   5194 N  N     . ILE A 1 1063 ? 173.878 162.117 129.841 1.00 80.16  ? 1408 ILE A N     1 
ATOM   5195 C  CA    . ILE A 1 1063 ? 173.654 160.921 129.036 1.00 77.32  ? 1408 ILE A CA    1 
ATOM   5196 C  C     . ILE A 1 1063 ? 172.412 160.201 129.543 1.00 71.73  ? 1408 ILE A C     1 
ATOM   5197 O  O     . ILE A 1 1063 ? 172.317 159.867 130.729 1.00 70.17  ? 1408 ILE A O     1 
ATOM   5198 C  CB    . ILE A 1 1063 ? 174.884 159.996 129.062 1.00 77.70  ? 1408 ILE A CB    1 
ATOM   5199 C  CG1   . ILE A 1 1063 ? 174.521 158.596 128.567 1.00 76.33  ? 1408 ILE A CG1   1 
ATOM   5200 C  CG2   . ILE A 1 1063 ? 175.495 159.952 130.453 1.00 79.31  ? 1408 ILE A CG2   1 
ATOM   5201 C  CD1   . ILE A 1 1063 ? 175.708 157.669 128.465 1.00 76.46  ? 1408 ILE A CD1   1 
ATOM   5202 N  N     . LEU A 1 1064 ? 171.465 159.961 128.640 1.00 64.90  ? 1409 LEU A N     1 
ATOM   5203 C  CA    . LEU A 1 1064 ? 170.232 159.242 128.926 1.00 64.84  ? 1409 LEU A CA    1 
ATOM   5204 C  C     . LEU A 1 1064 ? 170.281 157.869 128.276 1.00 68.55  ? 1409 LEU A C     1 
ATOM   5205 O  O     . LEU A 1 1064 ? 170.627 157.749 127.097 1.00 79.33  ? 1409 LEU A O     1 
ATOM   5206 C  CB    . LEU A 1 1064 ? 169.015 160.021 128.424 1.00 68.03  ? 1409 LEU A CB    1 
ATOM   5207 C  CG    . LEU A 1 1064 ? 167.651 159.339 128.526 1.00 66.34  ? 1409 LEU A CG    1 
ATOM   5208 C  CD1   . LEU A 1 1064 ? 166.933 159.663 129.816 1.00 61.64  ? 1409 LEU A CD1   1 
ATOM   5209 C  CD2   . LEU A 1 1064 ? 166.807 159.762 127.341 1.00 62.64  ? 1409 LEU A CD2   1 
ATOM   5210 N  N     . ARG A 1 1065 ? 169.927 156.844 129.043 1.00 60.68  ? 1410 ARG A N     1 
ATOM   5211 C  CA    . ARG A 1 1065 ? 169.996 155.465 128.594 1.00 57.17  ? 1410 ARG A CA    1 
ATOM   5212 C  C     . ARG A 1 1065 ? 168.603 154.857 128.548 1.00 52.75  ? 1410 ARG A C     1 
ATOM   5213 O  O     . ARG A 1 1065 ? 167.694 155.294 129.257 1.00 59.65  ? 1410 ARG A O     1 
ATOM   5214 C  CB    . ARG A 1 1065 ? 170.888 154.626 129.514 1.00 63.71  ? 1410 ARG A CB    1 
ATOM   5215 C  CG    . ARG A 1 1065 ? 172.283 154.371 128.977 1.00 64.43  ? 1410 ARG A CG    1 
ATOM   5216 C  CD    . ARG A 1 1065 ? 173.048 153.427 129.886 1.00 64.95  ? 1410 ARG A CD    1 
ATOM   5217 N  NE    . ARG A 1 1065 ? 173.177 153.957 131.237 1.00 73.58  ? 1410 ARG A NE    1 
ATOM   5218 C  CZ    . ARG A 1 1065 ? 174.062 154.875 131.601 1.00 72.75  ? 1410 ARG A CZ    1 
ATOM   5219 N  NH1   . ARG A 1 1065 ? 174.922 155.387 130.738 1.00 68.50  ? 1410 ARG A NH1   1 
ATOM   5220 N  NH2   . ARG A 1 1065 ? 174.085 155.288 132.866 1.00 65.08  ? 1410 ARG A NH2   1 
ATOM   5221 N  N     . ASP A 1 1066 ? 168.450 153.844 127.697 1.00 48.78  ? 1411 ASP A N     1 
ATOM   5222 C  CA    . ASP A 1 1066 ? 167.233 153.037 127.637 1.00 49.64  ? 1411 ASP A CA    1 
ATOM   5223 C  C     . ASP A 1 1066 ? 166.007 153.877 127.287 1.00 56.66  ? 1411 ASP A C     1 
ATOM   5224 O  O     . ASP A 1 1066 ? 164.939 153.723 127.879 1.00 58.27  ? 1411 ASP A O     1 
ATOM   5225 C  CB    . ASP A 1 1066 ? 167.013 152.281 128.947 1.00 51.64  ? 1411 ASP A CB    1 
ATOM   5226 C  CG    . ASP A 1 1066 ? 168.272 151.604 129.446 1.00 62.59  ? 1411 ASP A CG    1 
ATOM   5227 O  OD1   . ASP A 1 1066 ? 169.056 151.112 128.609 1.00 63.07  ? 1411 ASP A OD1   1 
ATOM   5228 O  OD2   . ASP A 1 1066 ? 168.478 151.564 130.677 1.00 59.82  ? 1411 ASP A OD2   1 
ATOM   5229 N  N     . HIS A 1 1067 ? 166.162 154.784 126.323 1.00 52.65  ? 1412 HIS A N     1 
ATOM   5230 C  CA    . HIS A 1 1067 ? 165.026 155.492 125.734 1.00 47.36  ? 1412 HIS A CA    1 
ATOM   5231 C  C     . HIS A 1 1067 ? 164.710 154.835 124.394 1.00 45.69  ? 1412 HIS A C     1 
ATOM   5232 O  O     . HIS A 1 1067 ? 165.047 155.340 123.324 1.00 48.91  ? 1412 HIS A O     1 
ATOM   5233 C  CB    . HIS A 1 1067 ? 165.327 156.977 125.583 1.00 47.16  ? 1412 HIS A CB    1 
ATOM   5234 C  CG    . HIS A 1 1067 ? 164.104 157.831 125.475 1.00 44.69  ? 1412 HIS A CG    1 
ATOM   5235 N  ND1   . HIS A 1 1067 ? 162.877 157.436 125.962 1.00 42.58  ? 1412 HIS A ND1   1 
ATOM   5236 C  CD2   . HIS A 1 1067 ? 163.918 159.059 124.939 1.00 47.30  ? 1412 HIS A CD2   1 
ATOM   5237 C  CE1   . HIS A 1 1067 ? 161.988 158.384 125.729 1.00 47.42  ? 1412 HIS A CE1   1 
ATOM   5238 N  NE2   . HIS A 1 1067 ? 162.594 159.380 125.110 1.00 44.99  ? 1412 HIS A NE2   1 
ATOM   5239 N  N     . ILE A 1 1068 ? 164.055 153.681 124.465 1.00 46.31  ? 1413 ILE A N     1 
ATOM   5240 C  CA    . ILE A 1 1068 ? 163.746 152.876 123.292 1.00 44.63  ? 1413 ILE A CA    1 
ATOM   5241 C  C     . ILE A 1 1068 ? 162.297 152.424 123.371 1.00 51.19  ? 1413 ILE A C     1 
ATOM   5242 O  O     . ILE A 1 1068 ? 161.793 152.112 124.455 1.00 60.52  ? 1413 ILE A O     1 
ATOM   5243 C  CB    . ILE A 1 1068 ? 164.687 151.662 123.177 1.00 49.41  ? 1413 ILE A CB    1 
ATOM   5244 C  CG1   . ILE A 1 1068 ? 164.889 151.017 124.545 1.00 50.56  ? 1413 ILE A CG1   1 
ATOM   5245 C  CG2   . ILE A 1 1068 ? 166.020 152.081 122.598 1.00 54.90  ? 1413 ILE A CG2   1 
ATOM   5246 C  CD1   . ILE A 1 1068 ? 165.804 149.820 124.518 1.00 54.24  ? 1413 ILE A CD1   1 
ATOM   5247 N  N     . CYS A 1 1069 ? 161.629 152.389 122.223 1.00 66.72  ? 1414 CYS A N     1 
ATOM   5248 C  CA    . CYS A 1 1069 ? 160.249 151.944 122.125 1.00 66.91  ? 1414 CYS A CA    1 
ATOM   5249 C  C     . CYS A 1 1069 ? 160.176 150.717 121.229 1.00 71.32  ? 1414 CYS A C     1 
ATOM   5250 O  O     . CYS A 1 1069 ? 160.973 150.560 120.301 1.00 77.44  ? 1414 CYS A O     1 
ATOM   5251 C  CB    . CYS A 1 1069 ? 159.348 153.046 121.564 1.00 66.81  ? 1414 CYS A CB    1 
ATOM   5252 S  SG    . CYS A 1 1069 ? 159.618 154.673 122.297 1.00 85.31  ? 1414 CYS A SG    1 
ATOM   5253 N  N     . LYS A 1 1070 ? 159.218 149.840 121.519 1.00 72.36  ? 1415 LYS A N     1 
ATOM   5254 C  CA    . LYS A 1 1070 ? 159.057 148.637 120.716 1.00 74.22  ? 1415 LYS A CA    1 
ATOM   5255 C  C     . LYS A 1 1070 ? 158.707 149.003 119.280 1.00 70.41  ? 1415 LYS A C     1 
ATOM   5256 O  O     . LYS A 1 1070 ? 157.966 149.955 119.026 1.00 80.80  ? 1415 LYS A O     1 
ATOM   5257 C  CB    . LYS A 1 1070 ? 157.972 147.741 121.310 1.00 77.59  ? 1415 LYS A CB    1 
ATOM   5258 C  CG    . LYS A 1 1070 ? 158.449 146.870 122.456 1.00 74.94  ? 1415 LYS A CG    1 
ATOM   5259 C  CD    . LYS A 1 1070 ? 157.334 146.603 123.444 1.00 72.18  ? 1415 LYS A CD    1 
ATOM   5260 C  CE    . LYS A 1 1070 ? 156.079 146.134 122.733 1.00 72.45  ? 1415 LYS A CE    1 
ATOM   5261 N  NZ    . LYS A 1 1070 ? 156.264 144.796 122.115 1.00 78.43  ? 1415 LYS A NZ    1 
ATOM   5262 N  N     . ASP A 1 1071 ? 159.250 148.240 118.335 1.00 70.98  ? 1416 ASP A N     1 
ATOM   5263 C  CA    . ASP A 1 1071 ? 159.053 148.516 116.915 1.00 77.59  ? 1416 ASP A CA    1 
ATOM   5264 C  C     . ASP A 1 1071 ? 157.716 147.931 116.480 1.00 79.90  ? 1416 ASP A C     1 
ATOM   5265 O  O     . ASP A 1 1071 ? 157.596 146.727 116.245 1.00 81.24  ? 1416 ASP A O     1 
ATOM   5266 C  CB    . ASP A 1 1071 ? 160.199 147.942 116.092 1.00 81.29  ? 1416 ASP A CB    1 
ATOM   5267 C  CG    . ASP A 1 1071 ? 160.102 148.308 114.625 1.00 81.87  ? 1416 ASP A CG    1 
ATOM   5268 O  OD1   . ASP A 1 1071 ? 159.734 149.462 114.323 1.00 83.03  ? 1416 ASP A OD1   1 
ATOM   5269 O  OD2   . ASP A 1 1071 ? 160.391 147.442 113.773 1.00 81.22  ? 1416 ASP A OD2   1 
ATOM   5270 N  N     . MET A 1 1072 ? 156.706 148.787 116.371 1.00 74.48  ? 1417 MET A N     1 
ATOM   5271 C  CA    . MET A 1 1072 ? 155.391 148.354 115.929 1.00 71.80  ? 1417 MET A CA    1 
ATOM   5272 C  C     . MET A 1 1072 ? 155.327 148.305 114.409 1.00 74.14  ? 1417 MET A C     1 
ATOM   5273 O  O     . MET A 1 1072 ? 156.010 149.060 113.712 1.00 79.43  ? 1417 MET A O     1 
ATOM   5274 C  CB    . MET A 1 1072 ? 154.309 149.288 116.468 1.00 68.98  ? 1417 MET A CB    1 
ATOM   5275 C  CG    . MET A 1 1072 ? 154.149 149.238 117.975 1.00 73.91  ? 1417 MET A CG    1 
ATOM   5276 S  SD    . MET A 1 1072 ? 153.892 147.563 118.584 1.00 88.57  ? 1417 MET A SD    1 
ATOM   5277 C  CE    . MET A 1 1072 ? 153.902 147.849 120.349 1.00 71.83  ? 1417 MET A CE    1 
ATOM   5278 N  N     . SER A 1 1073 ? 154.488 147.409 113.897 1.00 70.65  ? 1418 SER A N     1 
ATOM   5279 C  CA    . SER A 1 1073 ? 154.361 147.230 112.460 1.00 71.69  ? 1418 SER A CA    1 
ATOM   5280 C  C     . SER A 1 1073 ? 153.648 148.430 111.839 1.00 66.07  ? 1418 SER A C     1 
ATOM   5281 O  O     . SER A 1 1073 ? 153.298 149.403 112.511 1.00 69.43  ? 1418 SER A O     1 
ATOM   5282 C  CB    . SER A 1 1073 ? 153.623 145.930 112.155 1.00 76.75  ? 1418 SER A CB    1 
ATOM   5283 O  OG    . SER A 1 1073 ? 152.546 145.734 113.052 1.00 79.23  ? 1418 SER A OG    1 
ATOM   5284 N  N     . ALA A 1 1074 ? 153.442 148.360 110.522 1.00 59.04  ? 1419 ALA A N     1 
ATOM   5285 C  CA    . ALA A 1 1074 ? 152.816 149.471 109.813 1.00 63.42  ? 1419 ALA A CA    1 
ATOM   5286 C  C     . ALA A 1 1074 ? 151.371 149.674 110.251 1.00 68.12  ? 1419 ALA A C     1 
ATOM   5287 O  O     . ALA A 1 1074 ? 150.936 150.812 110.461 1.00 73.50  ? 1419 ALA A O     1 
ATOM   5288 C  CB    . ALA A 1 1074 ? 152.891 149.237 108.307 1.00 71.22  ? 1419 ALA A CB    1 
ATOM   5289 N  N     . LEU A 1 1075 ? 150.611 148.585 110.387 1.00 62.07  ? 1420 LEU A N     1 
ATOM   5290 C  CA    . LEU A 1 1075 ? 149.209 148.714 110.769 1.00 54.43  ? 1420 LEU A CA    1 
ATOM   5291 C  C     . LEU A 1 1075 ? 149.065 149.270 112.177 1.00 55.01  ? 1420 LEU A C     1 
ATOM   5292 O  O     . LEU A 1 1075 ? 148.199 150.114 112.430 1.00 64.02  ? 1420 LEU A O     1 
ATOM   5293 C  CB    . LEU A 1 1075 ? 148.501 147.368 110.656 1.00 54.61  ? 1420 LEU A CB    1 
ATOM   5294 C  CG    . LEU A 1 1075 ? 146.989 147.440 110.853 1.00 49.66  ? 1420 LEU A CG    1 
ATOM   5295 C  CD1   . LEU A 1 1075 ? 146.394 148.504 109.953 1.00 50.88  ? 1420 LEU A CD1   1 
ATOM   5296 C  CD2   . LEU A 1 1075 ? 146.355 146.093 110.579 1.00 62.56  ? 1420 LEU A CD2   1 
ATOM   5297 N  N     . VAL A 1 1076 ? 149.901 148.811 113.107 1.00 52.60  ? 1421 VAL A N     1 
ATOM   5298 C  CA    . VAL A 1 1076 ? 149.817 149.311 114.474 1.00 51.72  ? 1421 VAL A CA    1 
ATOM   5299 C  C     . VAL A 1 1076 ? 150.255 150.769 114.540 1.00 54.08  ? 1421 VAL A C     1 
ATOM   5300 O  O     . VAL A 1 1076 ? 149.693 151.563 115.303 1.00 59.46  ? 1421 VAL A O     1 
ATOM   5301 C  CB    . VAL A 1 1076 ? 150.637 148.420 115.420 1.00 46.67  ? 1421 VAL A CB    1 
ATOM   5302 C  CG1   . VAL A 1 1076 ? 150.336 148.771 116.859 1.00 48.47  ? 1421 VAL A CG1   1 
ATOM   5303 C  CG2   . VAL A 1 1076 ? 150.322 146.962 115.160 1.00 51.92  ? 1421 VAL A CG2   1 
ATOM   5304 N  N     . ALA A 1 1077 ? 151.257 151.149 113.746 1.00 50.83  ? 1422 ALA A N     1 
ATOM   5305 C  CA    . ALA A 1 1077 ? 151.652 152.553 113.691 1.00 46.58  ? 1422 ALA A CA    1 
ATOM   5306 C  C     . ALA A 1 1077 ? 150.526 153.420 113.143 1.00 49.93  ? 1422 ALA A C     1 
ATOM   5307 O  O     . ALA A 1 1077 ? 150.283 154.525 113.640 1.00 60.56  ? 1422 ALA A O     1 
ATOM   5308 C  CB    . ALA A 1 1077 ? 152.914 152.715 112.846 1.00 52.94  ? 1422 ALA A CB    1 
ATOM   5309 N  N     . ALA A 1 1078 ? 149.826 152.936 112.115 1.00 50.30  ? 1423 ALA A N     1 
ATOM   5310 C  CA    . ALA A 1 1078 ? 148.687 153.681 111.588 1.00 49.71  ? 1423 ALA A CA    1 
ATOM   5311 C  C     . ALA A 1 1078 ? 147.568 153.782 112.619 1.00 51.68  ? 1423 ALA A C     1 
ATOM   5312 O  O     . ALA A 1 1078 ? 146.902 154.817 112.721 1.00 58.94  ? 1423 ALA A O     1 
ATOM   5313 C  CB    . ALA A 1 1078 ? 148.179 153.027 110.305 1.00 53.12  ? 1423 ALA A CB    1 
ATOM   5314 N  N     . ARG A 1 1079 ? 147.336 152.710 113.380 1.00 48.57  ? 1424 ARG A N     1 
ATOM   5315 C  CA    . ARG A 1 1079 ? 146.323 152.753 114.430 1.00 48.16  ? 1424 ARG A CA    1 
ATOM   5316 C  C     . ARG A 1 1079 ? 146.679 153.782 115.494 1.00 51.89  ? 1424 ARG A C     1 
ATOM   5317 O  O     . ARG A 1 1079 ? 145.830 154.570 115.924 1.00 57.80  ? 1424 ARG A O     1 
ATOM   5318 C  CB    . ARG A 1 1079 ? 146.158 151.372 115.062 1.00 40.60  ? 1424 ARG A CB    1 
ATOM   5319 C  CG    . ARG A 1 1079 ? 145.414 150.378 114.206 1.00 41.86  ? 1424 ARG A CG    1 
ATOM   5320 C  CD    . ARG A 1 1079 ? 145.381 149.018 114.868 1.00 42.99  ? 1424 ARG A CD    1 
ATOM   5321 N  NE    . ARG A 1 1079 ? 144.834 147.993 113.990 1.00 52.39  ? 1424 ARG A NE    1 
ATOM   5322 C  CZ    . ARG A 1 1079 ? 144.935 146.690 114.210 1.00 57.62  ? 1424 ARG A CZ    1 
ATOM   5323 N  NH1   . ARG A 1 1079 ? 145.551 146.215 115.279 1.00 58.38  ? 1424 ARG A NH1   1 
ATOM   5324 N  NH2   . ARG A 1 1079 ? 144.406 145.841 113.334 1.00 55.37  ? 1424 ARG A NH2   1 
ATOM   5325 N  N     . MET A 1 1080 ? 147.937 153.793 115.933 1.00 39.77  ? 1425 MET A N     1 
ATOM   5326 C  CA    . MET A 1 1080 ? 148.361 154.763 116.934 1.00 40.09  ? 1425 MET A CA    1 
ATOM   5327 C  C     . MET A 1 1080 ? 148.553 156.158 116.360 1.00 49.24  ? 1425 MET A C     1 
ATOM   5328 O  O     . MET A 1 1080 ? 148.791 157.095 117.127 1.00 57.89  ? 1425 MET A O     1 
ATOM   5329 C  CB    . MET A 1 1080 ? 149.649 154.298 117.615 1.00 40.74  ? 1425 MET A CB    1 
ATOM   5330 C  CG    . MET A 1 1080 ? 149.598 152.872 118.128 1.00 47.92  ? 1425 MET A CG    1 
ATOM   5331 S  SD    . MET A 1 1080 ? 151.201 152.052 118.145 1.00 63.50  ? 1425 MET A SD    1 
ATOM   5332 C  CE    . MET A 1 1080 ? 152.306 153.455 118.126 1.00 47.15  ? 1425 MET A CE    1 
ATOM   5333 N  N     . ARG A 1 1081 ? 148.473 156.320 115.040 1.00 54.37  ? 1426 ARG A N     1 
ATOM   5334 C  CA    . ARG A 1 1081 ? 148.544 157.655 114.462 1.00 47.67  ? 1426 ARG A CA    1 
ATOM   5335 C  C     . ARG A 1 1081 ? 147.187 158.348 114.450 1.00 52.75  ? 1426 ARG A C     1 
ATOM   5336 O  O     . ARG A 1 1081 ? 147.124 159.579 114.532 1.00 61.91  ? 1426 ARG A O     1 
ATOM   5337 C  CB    . ARG A 1 1081 ? 149.106 157.584 113.042 1.00 51.18  ? 1426 ARG A CB    1 
ATOM   5338 C  CG    . ARG A 1 1081 ? 149.350 158.940 112.403 1.00 58.33  ? 1426 ARG A CG    1 
ATOM   5339 C  CD    . ARG A 1 1081 ? 149.546 158.826 110.901 1.00 59.48  ? 1426 ARG A CD    1 
ATOM   5340 N  NE    . ARG A 1 1081 ? 150.377 157.685 110.534 1.00 62.68  ? 1426 ARG A NE    1 
ATOM   5341 C  CZ    . ARG A 1 1081 ? 151.689 157.620 110.716 1.00 63.93  ? 1426 ARG A CZ    1 
ATOM   5342 N  NH1   . ARG A 1 1081 ? 152.361 158.618 111.266 1.00 64.82  ? 1426 ARG A NH1   1 
ATOM   5343 N  NH2   . ARG A 1 1081 ? 152.343 156.526 110.336 1.00 61.25  ? 1426 ARG A NH2   1 
ATOM   5344 N  N     . HIS A 1 1082 ? 146.099 157.588 114.361 1.00 50.78  ? 1427 HIS A N     1 
ATOM   5345 C  CA    . HIS A 1 1082 ? 144.766 158.155 114.231 1.00 50.93  ? 1427 HIS A CA    1 
ATOM   5346 C  C     . HIS A 1 1082 ? 144.045 158.311 115.564 1.00 54.45  ? 1427 HIS A C     1 
ATOM   5347 O  O     . HIS A 1 1082 ? 142.905 158.783 115.583 1.00 65.41  ? 1427 HIS A O     1 
ATOM   5348 C  CB    . HIS A 1 1082 ? 143.922 157.298 113.287 1.00 52.04  ? 1427 HIS A CB    1 
ATOM   5349 C  CG    . HIS A 1 1082 ? 144.266 157.476 111.842 1.00 53.92  ? 1427 HIS A CG    1 
ATOM   5350 N  ND1   . HIS A 1 1082 ? 145.564 157.481 111.381 1.00 56.24  ? 1427 HIS A ND1   1 
ATOM   5351 C  CD2   . HIS A 1 1082 ? 143.480 157.655 110.755 1.00 55.10  ? 1427 HIS A CD2   1 
ATOM   5352 C  CE1   . HIS A 1 1082 ? 145.563 157.656 110.072 1.00 56.73  ? 1427 HIS A CE1   1 
ATOM   5353 N  NE2   . HIS A 1 1082 ? 144.311 157.765 109.667 1.00 60.82  ? 1427 HIS A NE2   1 
ATOM   5354 N  N     . ILE A 1 1083 ? 144.671 157.929 116.670 1.00 44.92  ? 1428 ILE A N     1 
ATOM   5355 C  CA    . ILE A 1 1083 ? 144.090 158.099 117.998 1.00 42.89  ? 1428 ILE A CA    1 
ATOM   5356 C  C     . ILE A 1 1083 ? 144.283 159.557 118.407 1.00 46.71  ? 1428 ILE A C     1 
ATOM   5357 O  O     . ILE A 1 1083 ? 145.432 160.022 118.462 1.00 52.85  ? 1428 ILE A O     1 
ATOM   5358 C  CB    . ILE A 1 1083 ? 144.733 157.153 119.017 1.00 44.98  ? 1428 ILE A CB    1 
ATOM   5359 C  CG1   . ILE A 1 1083 ? 144.452 155.696 118.660 1.00 38.81  ? 1428 ILE A CG1   1 
ATOM   5360 C  CG2   . ILE A 1 1083 ? 144.228 157.458 120.410 1.00 50.06  ? 1428 ILE A CG2   1 
ATOM   5361 C  CD1   . ILE A 1 1083 ? 143.085 155.230 119.054 1.00 41.22  ? 1428 ILE A CD1   1 
ATOM   5362 N  N     . PRO A 1 1084 ? 143.217 160.298 118.697 1.00 51.62  ? 1429 PRO A N     1 
ATOM   5363 C  CA    . PRO A 1 1084 ? 143.368 161.720 119.020 1.00 54.55  ? 1429 PRO A CA    1 
ATOM   5364 C  C     . PRO A 1 1084 ? 143.984 161.930 120.394 1.00 56.32  ? 1429 PRO A C     1 
ATOM   5365 O  O     . PRO A 1 1084 ? 143.986 161.046 121.252 1.00 58.24  ? 1429 PRO A O     1 
ATOM   5366 C  CB    . PRO A 1 1084 ? 141.933 162.247 118.973 1.00 54.57  ? 1429 PRO A CB    1 
ATOM   5367 C  CG    . PRO A 1 1084 ? 141.105 161.065 119.302 1.00 54.82  ? 1429 PRO A CG    1 
ATOM   5368 C  CD    . PRO A 1 1084 ? 141.808 159.880 118.702 1.00 54.24  ? 1429 PRO A CD    1 
ATOM   5369 N  N     . LEU A 1 1085 ? 144.498 163.142 120.596 1.00 60.44  ? 1430 LEU A N     1 
ATOM   5370 C  CA    . LEU A 1 1085 ? 145.217 163.492 121.815 1.00 59.61  ? 1430 LEU A CA    1 
ATOM   5371 C  C     . LEU A 1 1085 ? 144.301 163.881 122.968 1.00 66.37  ? 1430 LEU A C     1 
ATOM   5372 O  O     . LEU A 1 1085 ? 144.805 164.156 124.062 1.00 67.47  ? 1430 LEU A O     1 
ATOM   5373 C  CB    . LEU A 1 1085 ? 146.190 164.640 121.538 1.00 53.03  ? 1430 LEU A CB    1 
ATOM   5374 C  CG    . LEU A 1 1085 ? 146.905 164.625 120.189 1.00 57.22  ? 1430 LEU A CG    1 
ATOM   5375 C  CD1   . LEU A 1 1085 ? 147.721 165.892 120.005 1.00 61.82  ? 1430 LEU A CD1   1 
ATOM   5376 C  CD2   . LEU A 1 1085 ? 147.791 163.401 120.073 1.00 56.12  ? 1430 LEU A CD2   1 
ATOM   5377 N  N     . ALA A 1 1086 ? 142.990 163.922 122.759 1.00 62.98  ? 1431 ALA A N     1 
ATOM   5378 C  CA    . ALA A 1 1086 ? 142.085 164.302 123.832 1.00 54.27  ? 1431 ALA A CA    1 
ATOM   5379 C  C     . ALA A 1 1086 ? 142.138 163.263 124.950 1.00 60.58  ? 1431 ALA A C     1 
ATOM   5380 O  O     . ALA A 1 1086 ? 142.277 162.066 124.676 1.00 68.49  ? 1431 ALA A O     1 
ATOM   5381 C  CB    . ALA A 1 1086 ? 140.656 164.439 123.307 1.00 53.87  ? 1431 ALA A CB    1 
ATOM   5382 N  N     . PRO A 1 1087 ? 142.046 163.682 126.212 1.00 68.88  ? 1432 PRO A N     1 
ATOM   5383 C  CA    . PRO A 1 1087 ? 142.101 162.717 127.316 1.00 64.48  ? 1432 PRO A CA    1 
ATOM   5384 C  C     . PRO A 1 1087 ? 140.961 161.713 127.246 1.00 65.96  ? 1432 PRO A C     1 
ATOM   5385 O  O     . PRO A 1 1087 ? 139.839 162.036 126.850 1.00 66.71  ? 1432 PRO A O     1 
ATOM   5386 C  CB    . PRO A 1 1087 ? 141.991 163.598 128.566 1.00 61.88  ? 1432 PRO A CB    1 
ATOM   5387 C  CG    . PRO A 1 1087 ? 142.413 164.954 128.117 1.00 68.10  ? 1432 PRO A CG    1 
ATOM   5388 C  CD    . PRO A 1 1087 ? 141.972 165.071 126.693 1.00 69.24  ? 1432 PRO A CD    1 
ATOM   5389 N  N     . GLY A 1 1088 ? 141.263 160.480 127.646 1.00 62.41  ? 1433 GLY A N     1 
ATOM   5390 C  CA    . GLY A 1 1088 ? 140.281 159.418 127.593 1.00 63.55  ? 1433 GLY A CA    1 
ATOM   5391 C  C     . GLY A 1 1088 ? 140.069 158.816 126.226 1.00 59.23  ? 1433 GLY A C     1 
ATOM   5392 O  O     . GLY A 1 1088 ? 139.033 158.185 125.995 1.00 59.55  ? 1433 GLY A O     1 
ATOM   5393 N  N     . SER A 1 1089 ? 141.012 158.995 125.307 1.00 45.52  ? 1434 SER A N     1 
ATOM   5394 C  CA    . SER A 1 1089 ? 140.893 158.460 123.960 1.00 45.00  ? 1434 SER A CA    1 
ATOM   5395 C  C     . SER A 1 1089 ? 141.519 157.076 123.885 1.00 52.67  ? 1434 SER A C     1 
ATOM   5396 O  O     . SER A 1 1089 ? 142.613 156.847 124.404 1.00 60.69  ? 1434 SER A O     1 
ATOM   5397 C  CB    . SER A 1 1089 ? 141.563 159.386 122.949 1.00 46.14  ? 1434 SER A CB    1 
ATOM   5398 O  OG    . SER A 1 1089 ? 140.766 160.529 122.703 1.00 59.66  ? 1434 SER A OG    1 
ATOM   5399 N  N     . ASP A 1 1090 ? 140.819 156.156 123.234 1.00 48.79  ? 1435 ASP A N     1 
ATOM   5400 C  CA    . ASP A 1 1090 ? 141.316 154.799 123.043 1.00 37.30  ? 1435 ASP A CA    1 
ATOM   5401 C  C     . ASP A 1 1090 ? 140.778 154.286 121.713 1.00 34.16  ? 1435 ASP A C     1 
ATOM   5402 O  O     . ASP A 1 1090 ? 140.357 155.069 120.857 1.00 41.40  ? 1435 ASP A O     1 
ATOM   5403 C  CB    . ASP A 1 1090 ? 140.943 153.903 124.237 1.00 43.20  ? 1435 ASP A CB    1 
ATOM   5404 C  CG    . ASP A 1 1090 ? 139.500 154.045 124.653 1.00 52.28  ? 1435 ASP A CG    1 
ATOM   5405 O  OD1   . ASP A 1 1090 ? 138.610 153.902 123.792 1.00 56.96  ? 1435 ASP A OD1   1 
ATOM   5406 O  OD2   . ASP A 1 1090 ? 139.251 154.285 125.850 1.00 53.93  ? 1435 ASP A OD2   1 
ATOM   5407 N  N     . TRP A 1 1091 ? 140.796 152.965 121.538 1.00 37.90  ? 1436 TRP A N     1 
ATOM   5408 C  CA    . TRP A 1 1091 ? 140.455 152.360 120.256 1.00 41.40  ? 1436 TRP A CA    1 
ATOM   5409 C  C     . TRP A 1 1091 ? 139.031 152.661 119.815 1.00 44.53  ? 1436 TRP A C     1 
ATOM   5410 O  O     . TRP A 1 1091 ? 138.721 152.505 118.629 1.00 49.48  ? 1436 TRP A O     1 
ATOM   5411 C  CB    . TRP A 1 1091 ? 140.639 150.847 120.335 1.00 35.89  ? 1436 TRP A CB    1 
ATOM   5412 C  CG    . TRP A 1 1091 ? 139.560 150.194 121.122 1.00 37.76  ? 1436 TRP A CG    1 
ATOM   5413 C  CD1   . TRP A 1 1091 ? 139.554 149.956 122.461 1.00 43.87  ? 1436 TRP A CD1   1 
ATOM   5414 C  CD2   . TRP A 1 1091 ? 138.310 149.707 120.623 1.00 39.37  ? 1436 TRP A CD2   1 
ATOM   5415 N  NE1   . TRP A 1 1091 ? 138.382 149.346 122.829 1.00 45.65  ? 1436 TRP A NE1   1 
ATOM   5416 C  CE2   . TRP A 1 1091 ? 137.600 149.183 121.717 1.00 40.97  ? 1436 TRP A CE2   1 
ATOM   5417 C  CE3   . TRP A 1 1091 ? 137.724 149.665 119.356 1.00 33.52  ? 1436 TRP A CE3   1 
ATOM   5418 C  CZ2   . TRP A 1 1091 ? 136.337 148.624 121.584 1.00 36.96  ? 1436 TRP A CZ2   1 
ATOM   5419 C  CZ3   . TRP A 1 1091 ? 136.474 149.110 119.226 1.00 37.87  ? 1436 TRP A CZ3   1 
ATOM   5420 C  CH2   . TRP A 1 1091 ? 135.793 148.595 120.332 1.00 42.32  ? 1436 TRP A CH2   1 
ATOM   5421 N  N     . ARG A 1 1092 ? 138.157 153.072 120.737 1.00 51.69  ? 1437 ARG A N     1 
ATOM   5422 C  CA    . ARG A 1 1092 ? 136.735 153.181 120.422 1.00 43.67  ? 1437 ARG A CA    1 
ATOM   5423 C  C     . ARG A 1 1092 ? 136.469 154.208 119.335 1.00 42.41  ? 1437 ARG A C     1 
ATOM   5424 O  O     . ARG A 1 1092 ? 135.562 154.022 118.516 1.00 50.26  ? 1437 ARG A O     1 
ATOM   5425 C  CB    . ARG A 1 1092 ? 135.946 153.529 121.682 1.00 35.26  ? 1437 ARG A CB    1 
ATOM   5426 C  CG    . ARG A 1 1092 ? 135.551 152.317 122.495 1.00 37.46  ? 1437 ARG A CG    1 
ATOM   5427 C  CD    . ARG A 1 1092 ? 135.082 152.709 123.874 1.00 41.10  ? 1437 ARG A CD    1 
ATOM   5428 N  NE    . ARG A 1 1092 ? 136.165 153.229 124.696 1.00 36.98  ? 1437 ARG A NE    1 
ATOM   5429 C  CZ    . ARG A 1 1092 ? 136.145 153.258 126.020 1.00 49.80  ? 1437 ARG A CZ    1 
ATOM   5430 N  NH1   . ARG A 1 1092 ? 135.119 152.783 126.706 1.00 49.05  ? 1437 ARG A NH1   1 
ATOM   5431 N  NH2   . ARG A 1 1092 ? 137.179 153.778 126.673 1.00 53.26  ? 1437 ARG A NH2   1 
ATOM   5432 N  N     . ASP A 1 1093 ? 137.246 155.287 119.301 1.00 44.00  ? 1438 ASP A N     1 
ATOM   5433 C  CA    . ASP A 1 1093 ? 137.058 156.363 118.333 1.00 52.57  ? 1438 ASP A CA    1 
ATOM   5434 C  C     . ASP A 1 1093 ? 138.076 156.304 117.205 1.00 56.93  ? 1438 ASP A C     1 
ATOM   5435 O  O     . ASP A 1 1093 ? 138.560 157.338 116.738 1.00 55.62  ? 1438 ASP A O     1 
ATOM   5436 C  CB    . ASP A 1 1093 ? 137.116 157.708 119.040 1.00 49.39  ? 1438 ASP A CB    1 
ATOM   5437 C  CG    . ASP A 1 1093 ? 138.292 157.810 119.968 1.00 53.53  ? 1438 ASP A CG    1 
ATOM   5438 O  OD1   . ASP A 1 1093 ? 138.356 157.015 120.925 1.00 52.76  ? 1438 ASP A OD1   1 
ATOM   5439 O  OD2   . ASP A 1 1093 ? 139.151 158.679 119.743 1.00 58.01  ? 1438 ASP A OD2   1 
ATOM   5440 N  N     . LEU A 1 1094 ? 138.426 155.106 116.758 1.00 51.66  ? 1439 LEU A N     1 
ATOM   5441 C  CA    . LEU A 1 1094 ? 139.312 154.959 115.613 1.00 44.93  ? 1439 LEU A CA    1 
ATOM   5442 C  C     . LEU A 1 1094 ? 138.521 155.164 114.328 1.00 55.55  ? 1439 LEU A C     1 
ATOM   5443 O  O     . LEU A 1 1094 ? 137.511 154.483 114.122 1.00 58.64  ? 1439 LEU A O     1 
ATOM   5444 C  CB    . LEU A 1 1094 ? 139.959 153.584 115.614 1.00 39.74  ? 1439 LEU A CB    1 
ATOM   5445 C  CG    . LEU A 1 1094 ? 141.318 153.489 116.300 1.00 41.57  ? 1439 LEU A CG    1 
ATOM   5446 C  CD1   . LEU A 1 1094 ? 141.794 152.055 116.323 1.00 56.61  ? 1439 LEU A CD1   1 
ATOM   5447 C  CD2   . LEU A 1 1094 ? 142.318 154.370 115.589 1.00 45.19  ? 1439 LEU A CD2   1 
ATOM   5448 N  N     . PRO A 1 1095 ? 138.923 156.088 113.456 1.00 61.17  ? 1440 PRO A N     1 
ATOM   5449 C  CA    . PRO A 1 1095 ? 138.183 156.285 112.205 1.00 56.47  ? 1440 PRO A CA    1 
ATOM   5450 C  C     . PRO A 1 1095 ? 138.178 155.024 111.355 1.00 61.41  ? 1440 PRO A C     1 
ATOM   5451 O  O     . PRO A 1 1095 ? 139.176 154.307 111.263 1.00 64.88  ? 1440 PRO A O     1 
ATOM   5452 C  CB    . PRO A 1 1095 ? 138.939 157.429 111.519 1.00 57.12  ? 1440 PRO A CB    1 
ATOM   5453 C  CG    . PRO A 1 1095 ? 140.266 157.483 112.191 1.00 57.24  ? 1440 PRO A CG    1 
ATOM   5454 C  CD    . PRO A 1 1095 ? 140.032 157.042 113.598 1.00 61.29  ? 1440 PRO A CD    1 
ATOM   5455 N  N     . ASN A 1 1096 ? 137.034 154.757 110.738 1.00 80.45  ? 1441 ASN A N     1 
ATOM   5456 C  CA    . ASN A 1 1096 ? 136.854 153.585 109.881 1.00 81.27  ? 1441 ASN A CA    1 
ATOM   5457 C  C     . ASN A 1 1096 ? 137.018 153.969 108.412 1.00 82.48  ? 1441 ASN A C     1 
ATOM   5458 O  O     . ASN A 1 1096 ? 136.088 153.893 107.611 1.00 82.49  ? 1441 ASN A O     1 
ATOM   5459 C  CB    . ASN A 1 1096 ? 135.490 152.955 110.138 1.00 80.15  ? 1441 ASN A CB    1 
ATOM   5460 C  CG    . ASN A 1 1096 ? 135.438 151.500 109.743 1.00 80.40  ? 1441 ASN A CG    1 
ATOM   5461 O  OD1   . ASN A 1 1096 ? 136.371 150.975 109.140 1.00 80.64  ? 1441 ASN A OD1   1 
ATOM   5462 N  ND2   . ASN A 1 1096 ? 134.340 150.836 110.080 1.00 81.05  ? 1441 ASN A ND2   1 
ATOM   5463 N  N     . ILE A 1 1097 ? 138.230 154.389 108.062 1.00 83.11  ? 1442 ILE A N     1 
ATOM   5464 C  CA    . ILE A 1 1097 ? 138.525 154.863 106.718 1.00 84.11  ? 1442 ILE A CA    1 
ATOM   5465 C  C     . ILE A 1 1097 ? 139.726 154.112 106.167 1.00 86.86  ? 1442 ILE A C     1 
ATOM   5466 O  O     . ILE A 1 1097 ? 140.595 153.651 106.914 1.00 87.55  ? 1442 ILE A O     1 
ATOM   5467 C  CB    . ILE A 1 1097 ? 138.783 156.386 106.686 1.00 83.93  ? 1442 ILE A CB    1 
ATOM   5468 C  CG1   . ILE A 1 1097 ? 140.098 156.724 107.389 1.00 81.45  ? 1442 ILE A CG1   1 
ATOM   5469 C  CG2   . ILE A 1 1097 ? 137.627 157.139 107.319 1.00 83.27  ? 1442 ILE A CG2   1 
ATOM   5470 C  CD1   . ILE A 1 1097 ? 140.423 158.201 107.399 1.00 82.21  ? 1442 ILE A CD1   1 
ATOM   5471 N  N     . GLU A 1 1098 ? 139.764 153.985 104.844 1.00 89.45  ? 1443 GLU A N     1 
ATOM   5472 C  CA    . GLU A 1 1098 ? 140.923 153.416 104.172 1.00 86.97  ? 1443 GLU A CA    1 
ATOM   5473 C  C     . GLU A 1 1098 ? 142.132 154.319 104.377 1.00 90.51  ? 1443 GLU A C     1 
ATOM   5474 O  O     . GLU A 1 1098 ? 142.039 155.542 104.231 1.00 93.33  ? 1443 GLU A O     1 
ATOM   5475 C  CB    . GLU A 1 1098 ? 140.629 153.239 102.683 1.00 89.24  ? 1443 GLU A CB    1 
ATOM   5476 C  CG    . GLU A 1 1098 ? 141.784 153.595 101.762 1.00 94.22  ? 1443 GLU A CG    1 
ATOM   5477 C  CD    . GLU A 1 1098 ? 141.387 153.582 100.300 1.00 93.04  ? 1443 GLU A CD    1 
ATOM   5478 O  OE1   . GLU A 1 1098 ? 140.767 152.593 99.859  1.00 91.43  ? 1443 GLU A OE1   1 
ATOM   5479 O  OE2   . GLU A 1 1098 ? 141.695 154.563 99.592  1.00 91.31  ? 1443 GLU A OE2   1 
ATOM   5480 N  N     . VAL A 1 1099 ? 143.270 153.719 104.725 1.00 82.06  ? 1444 VAL A N     1 
ATOM   5481 C  CA    . VAL A 1 1099 ? 144.490 154.468 104.985 1.00 84.03  ? 1444 VAL A CA    1 
ATOM   5482 C  C     . VAL A 1 1099 ? 145.650 153.794 104.265 1.00 83.91  ? 1444 VAL A C     1 
ATOM   5483 O  O     . VAL A 1 1099 ? 145.596 152.614 103.914 1.00 84.67  ? 1444 VAL A O     1 
ATOM   5484 C  CB    . VAL A 1 1099 ? 144.785 154.593 106.496 1.00 80.82  ? 1444 VAL A CB    1 
ATOM   5485 C  CG1   . VAL A 1 1099 ? 145.530 153.370 107.001 1.00 82.69  ? 1444 VAL A CG1   1 
ATOM   5486 C  CG2   . VAL A 1 1099 ? 145.565 155.867 106.788 1.00 82.27  ? 1444 VAL A CG2   1 
ATOM   5487 N  N     . ARG A 1 1100 ? 146.705 154.571 104.038 1.00 93.88  ? 1445 ARG A N     1 
ATOM   5488 C  CA    . ARG A 1 1100 ? 147.927 154.097 103.400 1.00 91.05  ? 1445 ARG A CA    1 
ATOM   5489 C  C     . ARG A 1 1100 ? 149.018 154.047 104.461 1.00 93.19  ? 1445 ARG A C     1 
ATOM   5490 O  O     . ARG A 1 1100 ? 149.403 155.083 105.012 1.00 94.38  ? 1445 ARG A O     1 
ATOM   5491 C  CB    . ARG A 1 1100 ? 148.323 155.008 102.239 1.00 93.18  ? 1445 ARG A CB    1 
ATOM   5492 C  CG    . ARG A 1 1100 ? 149.374 154.430 101.299 1.00 93.34  ? 1445 ARG A CG    1 
ATOM   5493 C  CD    . ARG A 1 1100 ? 149.129 152.961 100.979 1.00 93.79  ? 1445 ARG A CD    1 
ATOM   5494 N  NE    . ARG A 1 1100 ? 147.771 152.701 100.512 1.00 97.13  ? 1445 ARG A NE    1 
ATOM   5495 C  CZ    . ARG A 1 1100 ? 147.299 153.060 99.325  1.00 97.63  ? 1445 ARG A CZ    1 
ATOM   5496 N  NH1   . ARG A 1 1100 ? 148.053 153.695 98.442  1.00 95.60  ? 1445 ARG A NH1   1 
ATOM   5497 N  NH2   . ARG A 1 1100 ? 146.039 152.770 99.013  1.00 95.01  ? 1445 ARG A NH2   1 
ATOM   5498 N  N     . LEU A 1 1101 ? 149.516 152.846 104.742 1.00 88.59  ? 1446 LEU A N     1 
ATOM   5499 C  CA    . LEU A 1 1101 ? 150.489 152.661 105.808 1.00 90.45  ? 1446 LEU A CA    1 
ATOM   5500 C  C     . LEU A 1 1101 ? 151.853 153.214 105.391 1.00 93.04  ? 1446 LEU A C     1 
ATOM   5501 O  O     . LEU A 1 1101 ? 152.026 153.776 104.307 1.00 91.32  ? 1446 LEU A O     1 
ATOM   5502 C  CB    . LEU A 1 1101 ? 150.583 151.184 106.180 1.00 86.06  ? 1446 LEU A CB    1 
ATOM   5503 C  CG    . LEU A 1 1101 ? 149.269 150.407 106.118 1.00 84.67  ? 1446 LEU A CG    1 
ATOM   5504 C  CD1   . LEU A 1 1101 ? 149.527 148.913 106.109 1.00 88.57  ? 1446 LEU A CD1   1 
ATOM   5505 C  CD2   . LEU A 1 1101 ? 148.370 150.787 107.282 1.00 84.08  ? 1446 LEU A CD2   1 
ATOM   5506 N  N     . SER A 1 1102 ? 152.837 153.058 106.281 1.00 99.30  ? 1447 SER A N     1 
ATOM   5507 C  CA    . SER A 1 1102 ? 154.187 153.534 105.995 1.00 97.03  ? 1447 SER A CA    1 
ATOM   5508 C  C     . SER A 1 1102 ? 154.770 152.826 104.778 1.00 97.71  ? 1447 SER A C     1 
ATOM   5509 O  O     . SER A 1 1102 ? 155.243 153.469 103.835 1.00 94.19  ? 1447 SER A O     1 
ATOM   5510 C  CB    . SER A 1 1102 ? 155.083 153.332 107.218 1.00 98.42  ? 1447 SER A CB    1 
ATOM   5511 O  OG    . SER A 1 1102 ? 155.121 151.968 107.599 1.00 95.69  ? 1447 SER A OG    1 
ATOM   5512 N  N     . ASP A 1 1103 ? 154.746 151.498 104.785 1.00 100.82 ? 1448 ASP A N     1 
ATOM   5513 C  CA    . ASP A 1 1103 ? 155.054 150.737 103.586 1.00 100.28 ? 1448 ASP A CA    1 
ATOM   5514 C  C     . ASP A 1 1103 ? 153.842 150.736 102.664 1.00 102.55 ? 1448 ASP A C     1 
ATOM   5515 O  O     . ASP A 1 1103 ? 152.733 151.096 103.067 1.00 103.20 ? 1448 ASP A O     1 
ATOM   5516 C  CB    . ASP A 1 1103 ? 155.470 149.306 103.942 1.00 100.73 ? 1448 ASP A CB    1 
ATOM   5517 C  CG    . ASP A 1 1103 ? 154.294 148.425 104.329 1.00 100.18 ? 1448 ASP A CG    1 
ATOM   5518 O  OD1   . ASP A 1 1103 ? 154.134 148.145 105.534 1.00 99.16  ? 1448 ASP A OD1   1 
ATOM   5519 O  OD2   . ASP A 1 1103 ? 153.549 147.981 103.431 1.00 100.78 ? 1448 ASP A OD2   1 
ATOM   5520 N  N     . GLY A 1 1104 ? 154.056 150.332 101.415 1.00 108.02 ? 1449 GLY A N     1 
ATOM   5521 C  CA    . GLY A 1 1104 ? 152.951 150.339 100.479 1.00 107.76 ? 1449 GLY A CA    1 
ATOM   5522 C  C     . GLY A 1 1104 ? 152.005 149.178 100.709 1.00 107.58 ? 1449 GLY A C     1 
ATOM   5523 O  O     . GLY A 1 1104 ? 152.291 148.044 100.314 1.00 106.69 ? 1449 GLY A O     1 
ATOM   5524 N  N     . THR A 1 1105 ? 150.870 149.455 101.348 1.00 103.72 ? 1450 THR A N     1 
ATOM   5525 C  CA    . THR A 1 1105 ? 149.867 148.441 101.635 1.00 103.18 ? 1450 THR A CA    1 
ATOM   5526 C  C     . THR A 1 1105 ? 148.574 149.151 102.006 1.00 102.07 ? 1450 THR A C     1 
ATOM   5527 O  O     . THR A 1 1105 ? 148.585 150.245 102.574 1.00 104.62 ? 1450 THR A O     1 
ATOM   5528 C  CB    . THR A 1 1105 ? 150.306 147.489 102.763 1.00 103.94 ? 1450 THR A CB    1 
ATOM   5529 O  OG1   . THR A 1 1105 ? 151.655 147.057 102.548 1.00 106.53 ? 1450 THR A OG1   1 
ATOM   5530 C  CG2   . THR A 1 1105 ? 149.408 146.260 102.819 1.00 102.61 ? 1450 THR A CG2   1 
ATOM   5531 N  N     . MET A 1 1106 ? 147.461 148.508 101.691 1.00 93.53  ? 1451 MET A N     1 
ATOM   5532 C  CA    . MET A 1 1106 ? 146.142 149.085 101.886 1.00 93.86  ? 1451 MET A CA    1 
ATOM   5533 C  C     . MET A 1 1106 ? 145.491 148.522 103.146 1.00 95.42  ? 1451 MET A C     1 
ATOM   5534 O  O     . MET A 1 1106 ? 145.571 147.319 103.415 1.00 93.54  ? 1451 MET A O     1 
ATOM   5535 C  CB    . MET A 1 1106 ? 145.271 148.792 100.674 1.00 94.26  ? 1451 MET A CB    1 
ATOM   5536 C  CG    . MET A 1 1106 ? 143.794 148.739 100.981 1.00 94.49  ? 1451 MET A CG    1 
ATOM   5537 S  SD    . MET A 1 1106 ? 142.950 150.326 101.059 1.00 103.20 ? 1451 MET A SD    1 
ATOM   5538 C  CE    . MET A 1 1106 ? 141.281 149.810 101.454 1.00 96.03  ? 1451 MET A CE    1 
ATOM   5539 N  N     . ALA A 1 1107 ? 144.843 149.401 103.914 1.00 94.46  ? 1452 ALA A N     1 
ATOM   5540 C  CA    . ALA A 1 1107 ? 144.100 149.022 105.109 1.00 90.40  ? 1452 ALA A CA    1 
ATOM   5541 C  C     . ALA A 1 1107 ? 142.619 148.952 104.753 1.00 92.91  ? 1452 ALA A C     1 
ATOM   5542 O  O     . ALA A 1 1107 ? 141.978 149.988 104.550 1.00 91.85  ? 1452 ALA A O     1 
ATOM   5543 C  CB    . ALA A 1 1107 ? 144.334 150.020 106.241 1.00 87.66  ? 1452 ALA A CB    1 
ATOM   5544 N  N     . ARG A 1 1108 ? 142.080 147.735 104.676 1.00 94.24  ? 1453 ARG A N     1 
ATOM   5545 C  CA    . ARG A 1 1108 ? 140.662 147.525 104.409 1.00 93.86  ? 1453 ARG A CA    1 
ATOM   5546 C  C     . ARG A 1 1108 ? 139.773 148.262 105.413 1.00 93.77  ? 1453 ARG A C     1 
ATOM   5547 O  O     . ARG A 1 1108 ? 140.214 148.731 106.465 1.00 94.82  ? 1453 ARG A O     1 
ATOM   5548 C  CB    . ARG A 1 1108 ? 140.317 146.036 104.445 1.00 95.26  ? 1453 ARG A CB    1 
ATOM   5549 C  CG    . ARG A 1 1108 ? 140.699 145.187 103.237 1.00 94.32  ? 1453 ARG A CG    1 
ATOM   5550 C  CD    . ARG A 1 1108 ? 139.841 145.541 102.018 1.00 96.37  ? 1453 ARG A CD    1 
ATOM   5551 N  NE    . ARG A 1 1108 ? 140.381 146.572 101.143 1.00 96.18  ? 1453 ARG A NE    1 
ATOM   5552 C  CZ    . ARG A 1 1108 ? 141.247 146.328 100.171 1.00 95.81  ? 1453 ARG A CZ    1 
ATOM   5553 N  NH1   . ARG A 1 1108 ? 141.702 145.107 99.944  1.00 96.07  ? 1453 ARG A NH1   1 
ATOM   5554 N  NH2   . ARG A 1 1108 ? 141.625 147.320 99.373  1.00 94.54  ? 1453 ARG A NH2   1 
ATOM   5555 N  N     . LYS A 1 1109 ? 138.489 148.347 105.066 1.00 85.48  ? 1454 LYS A N     1 
ATOM   5556 C  CA    . LYS A 1 1109 ? 137.461 148.891 105.943 1.00 83.98  ? 1454 LYS A CA    1 
ATOM   5557 C  C     . LYS A 1 1109 ? 136.726 147.742 106.620 1.00 88.22  ? 1454 LYS A C     1 
ATOM   5558 O  O     . LYS A 1 1109 ? 136.301 146.793 105.953 1.00 91.88  ? 1454 LYS A O     1 
ATOM   5559 C  CB    . LYS A 1 1109 ? 136.469 149.755 105.162 1.00 85.98  ? 1454 LYS A CB    1 
ATOM   5560 C  CG    . LYS A 1 1109 ? 136.895 151.203 104.994 1.00 88.55  ? 1454 LYS A CG    1 
ATOM   5561 C  CD    . LYS A 1 1109 ? 135.766 152.059 104.432 1.00 89.38  ? 1454 LYS A CD    1 
ATOM   5562 C  CE    . LYS A 1 1109 ? 134.403 151.600 104.947 1.00 89.00  ? 1454 LYS A CE    1 
ATOM   5563 N  NZ    . LYS A 1 1109 ? 133.396 152.699 104.936 1.00 85.92  ? 1454 LYS A NZ    1 
ATOM   5564 N  N     . LEU A 1 1110 ? 136.584 147.823 107.939 1.00 83.43  ? 1455 LEU A N     1 
ATOM   5565 C  CA    . LEU A 1 1110 ? 135.878 146.782 108.672 1.00 80.63  ? 1455 LEU A CA    1 
ATOM   5566 C  C     . LEU A 1 1110 ? 134.404 146.773 108.293 1.00 82.51  ? 1455 LEU A C     1 
ATOM   5567 O  O     . LEU A 1 1110 ? 133.762 147.823 108.206 1.00 83.72  ? 1455 LEU A O     1 
ATOM   5568 C  CB    . LEU A 1 1110 ? 136.035 146.992 110.174 1.00 77.75  ? 1455 LEU A CB    1 
ATOM   5569 C  CG    . LEU A 1 1110 ? 135.556 145.839 111.054 1.00 78.65  ? 1455 LEU A CG    1 
ATOM   5570 C  CD1   . LEU A 1 1110 ? 136.022 144.510 110.489 1.00 79.48  ? 1455 LEU A CD1   1 
ATOM   5571 C  CD2   . LEU A 1 1110 ? 136.042 146.014 112.480 1.00 80.04  ? 1455 LEU A CD2   1 
ATOM   5572 N  N     . ARG A 1 1111 ? 133.867 145.576 108.070 1.00 92.01  ? 1456 ARG A N     1 
ATOM   5573 C  CA    . ARG A 1 1111 ? 132.500 145.395 107.601 1.00 94.40  ? 1456 ARG A CA    1 
ATOM   5574 C  C     . ARG A 1 1111 ? 131.677 144.688 108.666 1.00 93.61  ? 1456 ARG A C     1 
ATOM   5575 O  O     . ARG A 1 1111 ? 132.115 143.679 109.228 1.00 97.21  ? 1456 ARG A O     1 
ATOM   5576 C  CB    . ARG A 1 1111 ? 132.467 144.592 106.299 1.00 95.50  ? 1456 ARG A CB    1 
ATOM   5577 C  CG    . ARG A 1 1111 ? 133.508 145.015 105.279 1.00 94.48  ? 1456 ARG A CG    1 
ATOM   5578 C  CD    . ARG A 1 1111 ? 133.438 144.146 104.034 1.00 95.67  ? 1456 ARG A CD    1 
ATOM   5579 N  NE    . ARG A 1 1111 ? 133.567 142.727 104.340 1.00 99.16  ? 1456 ARG A NE    1 
ATOM   5580 C  CZ    . ARG A 1 1111 ? 134.689 142.137 104.731 1.00 97.93  ? 1456 ARG A CZ    1 
ATOM   5581 N  NH1   . ARG A 1 1111 ? 135.817 142.816 104.866 1.00 96.50  ? 1456 ARG A NH1   1 
ATOM   5582 N  NH2   . ARG A 1 1111 ? 134.680 140.833 104.988 1.00 95.82  ? 1456 ARG A NH2   1 
ATOM   5583 N  N     . TYR A 1 1112 ? 130.484 145.211 108.931 1.00 92.89  ? 1457 TYR A N     1 
ATOM   5584 C  CA    . TYR A 1 1112 ? 129.550 144.620 109.885 1.00 94.36  ? 1457 TYR A CA    1 
ATOM   5585 C  C     . TYR A 1 1112 ? 128.482 143.880 109.087 1.00 97.09  ? 1457 TYR A C     1 
ATOM   5586 O  O     . TYR A 1 1112 ? 127.602 144.500 108.486 1.00 99.18  ? 1457 TYR A O     1 
ATOM   5587 C  CB    . TYR A 1 1112 ? 128.941 145.692 110.782 1.00 95.75  ? 1457 TYR A CB    1 
ATOM   5588 C  CG    . TYR A 1 1112 ? 129.957 146.486 111.571 1.00 94.93  ? 1457 TYR A CG    1 
ATOM   5589 C  CD1   . TYR A 1 1112 ? 130.625 147.562 111.003 1.00 92.78  ? 1457 TYR A CD1   1 
ATOM   5590 C  CD2   . TYR A 1 1112 ? 130.240 146.165 112.888 1.00 95.54  ? 1457 TYR A CD2   1 
ATOM   5591 C  CE1   . TYR A 1 1112 ? 131.552 148.287 111.725 1.00 91.98  ? 1457 TYR A CE1   1 
ATOM   5592 C  CE2   . TYR A 1 1112 ? 131.163 146.882 113.615 1.00 92.64  ? 1457 TYR A CE2   1 
ATOM   5593 C  CZ    . TYR A 1 1112 ? 131.816 147.941 113.031 1.00 90.96  ? 1457 TYR A CZ    1 
ATOM   5594 O  OH    . TYR A 1 1112 ? 132.736 148.658 113.758 1.00 90.33  ? 1457 TYR A OH    1 
ATOM   5595 N  N     . THR A 1 1113 ? 128.563 142.550 109.078 1.00 112.59 ? 1458 THR A N     1 
ATOM   5596 C  CA    . THR A 1 1113 ? 127.656 141.726 108.291 1.00 112.65 ? 1458 THR A CA    1 
ATOM   5597 C  C     . THR A 1 1113 ? 126.607 141.005 109.128 1.00 111.38 ? 1458 THR A C     1 
ATOM   5598 O  O     . THR A 1 1113 ? 125.683 140.418 108.557 1.00 111.45 ? 1458 THR A O     1 
ATOM   5599 C  CB    . THR A 1 1113 ? 128.445 140.689 107.482 1.00 113.02 ? 1458 THR A CB    1 
ATOM   5600 O  OG1   . THR A 1 1113 ? 128.881 139.635 108.350 1.00 115.38 ? 1458 THR A OG1   1 
ATOM   5601 C  CG2   . THR A 1 1113 ? 129.656 141.334 106.829 1.00 110.00 ? 1458 THR A CG2   1 
ATOM   5602 N  N     . HIS A 1 1114 ? 126.720 141.033 110.452 1.00 117.77 ? 1459 HIS A N     1 
ATOM   5603 C  CA    . HIS A 1 1114 ? 125.784 140.351 111.333 1.00 119.46 ? 1459 HIS A CA    1 
ATOM   5604 C  C     . HIS A 1 1114 ? 125.104 141.360 112.246 1.00 120.77 ? 1459 HIS A C     1 
ATOM   5605 O  O     . HIS A 1 1114 ? 125.758 142.245 112.806 1.00 121.82 ? 1459 HIS A O     1 
ATOM   5606 C  CB    . HIS A 1 1114 ? 126.491 139.279 112.169 1.00 119.82 ? 1459 HIS A CB    1 
ATOM   5607 C  CG    . HIS A 1 1114 ? 127.146 138.211 111.351 1.00 120.43 ? 1459 HIS A CG    1 
ATOM   5608 N  ND1   . HIS A 1 1114 ? 128.485 138.238 111.026 1.00 120.44 ? 1459 HIS A ND1   1 
ATOM   5609 C  CD2   . HIS A 1 1114 ? 126.647 137.084 110.791 1.00 120.26 ? 1459 HIS A CD2   1 
ATOM   5610 C  CE1   . HIS A 1 1114 ? 128.783 137.174 110.302 1.00 120.06 ? 1459 HIS A CE1   1 
ATOM   5611 N  NE2   . HIS A 1 1114 ? 127.685 136.458 110.144 1.00 121.14 ? 1459 HIS A NE2   1 
ATOM   5612 N  N     . HIS A 1 1115 ? 123.789 141.226 112.385 1.00 128.12 ? 1460 HIS A N     1 
ATOM   5613 C  CA    . HIS A 1 1115 ? 123.029 142.125 113.240 1.00 128.46 ? 1460 HIS A CA    1 
ATOM   5614 C  C     . HIS A 1 1115 ? 123.363 141.886 114.707 1.00 127.85 ? 1460 HIS A C     1 
ATOM   5615 O  O     . HIS A 1 1115 ? 123.541 140.746 115.144 1.00 126.43 ? 1460 HIS A O     1 
ATOM   5616 C  CB    . HIS A 1 1115 ? 121.530 141.939 113.007 1.00 128.74 ? 1460 HIS A CB    1 
ATOM   5617 C  CG    . HIS A 1 1115 ? 120.672 142.565 114.062 1.00 129.46 ? 1460 HIS A CG    1 
ATOM   5618 N  ND1   . HIS A 1 1115 ? 119.851 141.827 114.887 1.00 129.57 ? 1460 HIS A ND1   1 
ATOM   5619 C  CD2   . HIS A 1 1115 ? 120.509 143.858 114.427 1.00 128.32 ? 1460 HIS A CD2   1 
ATOM   5620 C  CE1   . HIS A 1 1115 ? 119.218 142.639 115.715 1.00 128.74 ? 1460 HIS A CE1   1 
ATOM   5621 N  NE2   . HIS A 1 1115 ? 119.599 143.877 115.456 1.00 128.39 ? 1460 HIS A NE2   1 
ATOM   5622 N  N     . ASP A 1 1116 ? 123.449 142.974 115.469 1.00 130.51 ? 1461 ASP A N     1 
ATOM   5623 C  CA    . ASP A 1 1116 ? 123.724 142.919 116.901 1.00 131.63 ? 1461 ASP A CA    1 
ATOM   5624 C  C     . ASP A 1 1116 ? 122.396 142.996 117.646 1.00 132.89 ? 1461 ASP A C     1 
ATOM   5625 O  O     . ASP A 1 1116 ? 121.751 144.049 117.669 1.00 130.12 ? 1461 ASP A O     1 
ATOM   5626 C  CB    . ASP A 1 1116 ? 124.658 144.052 117.319 1.00 129.97 ? 1461 ASP A CB    1 
ATOM   5627 C  CG    . ASP A 1 1116 ? 125.366 143.772 118.629 1.00 131.14 ? 1461 ASP A CG    1 
ATOM   5628 O  OD1   . ASP A 1 1116 ? 124.795 143.056 119.478 1.00 131.67 ? 1461 ASP A OD1   1 
ATOM   5629 O  OD2   . ASP A 1 1116 ? 126.496 144.271 118.812 1.00 130.89 ? 1461 ASP A OD2   1 
ATOM   5630 N  N     . ARG A 1 1117 ? 121.988 141.879 118.252 1.00 137.47 ? 1462 ARG A N     1 
ATOM   5631 C  CA    . ARG A 1 1117 ? 120.715 141.852 118.964 1.00 136.76 ? 1462 ARG A CA    1 
ATOM   5632 C  C     . ARG A 1 1117 ? 120.789 142.636 120.269 1.00 136.20 ? 1462 ARG A C     1 
ATOM   5633 O  O     . ARG A 1 1117 ? 119.879 143.411 120.585 1.00 136.20 ? 1462 ARG A O     1 
ATOM   5634 C  CB    . ARG A 1 1117 ? 120.294 140.407 119.228 1.00 135.46 ? 1462 ARG A CB    1 
ATOM   5635 C  CG    . ARG A 1 1117 ? 119.928 139.629 117.974 1.00 134.80 ? 1462 ARG A CG    1 
ATOM   5636 C  CD    . ARG A 1 1117 ? 119.827 138.139 118.257 1.00 135.44 ? 1462 ARG A CD    1 
ATOM   5637 N  NE    . ARG A 1 1117 ? 119.197 137.867 119.543 1.00 136.04 ? 1462 ARG A NE    1 
ATOM   5638 C  CZ    . ARG A 1 1117 ? 117.904 137.622 119.706 1.00 136.03 ? 1462 ARG A CZ    1 
ATOM   5639 N  NH1   . ARG A 1 1117 ? 117.069 137.606 118.680 1.00 136.44 ? 1462 ARG A NH1   1 
ATOM   5640 N  NH2   . ARG A 1 1117 ? 117.438 137.386 120.929 1.00 134.98 ? 1462 ARG A NH2   1 
ATOM   5641 N  N     . LYS A 1 1118 ? 121.862 142.448 121.041 1.00 129.27 ? 1463 LYS A N     1 
ATOM   5642 C  CA    . LYS A 1 1118 ? 121.969 143.120 122.332 1.00 129.07 ? 1463 LYS A CA    1 
ATOM   5643 C  C     . LYS A 1 1118 ? 122.158 144.622 122.165 1.00 128.24 ? 1463 LYS A C     1 
ATOM   5644 O  O     . LYS A 1 1118 ? 121.534 145.415 122.879 1.00 127.42 ? 1463 LYS A O     1 
ATOM   5645 C  CB    . LYS A 1 1118 ? 123.118 142.518 123.141 1.00 128.67 ? 1463 LYS A CB    1 
ATOM   5646 C  CG    . LYS A 1 1118 ? 123.473 143.296 124.398 1.00 129.14 ? 1463 LYS A CG    1 
ATOM   5647 C  CD    . LYS A 1 1118 ? 124.750 142.768 125.031 1.00 127.05 ? 1463 LYS A CD    1 
ATOM   5648 C  CE    . LYS A 1 1118 ? 125.248 143.692 126.129 1.00 127.25 ? 1463 LYS A CE    1 
ATOM   5649 N  NZ    . LYS A 1 1118 ? 124.277 143.793 127.252 1.00 127.30 ? 1463 LYS A NZ    1 
ATOM   5650 N  N     . ASN A 1 1119 ? 123.012 145.033 121.229 1.00 125.71 ? 1464 ASN A N     1 
ATOM   5651 C  CA    . ASN A 1 1119 ? 123.283 146.445 121.003 1.00 128.42 ? 1464 ASN A CA    1 
ATOM   5652 C  C     . ASN A 1 1119 ? 122.319 147.093 120.018 1.00 129.44 ? 1464 ASN A C     1 
ATOM   5653 O  O     . ASN A 1 1119 ? 122.344 148.320 119.870 1.00 128.76 ? 1464 ASN A O     1 
ATOM   5654 C  CB    . ASN A 1 1119 ? 124.720 146.632 120.503 1.00 128.25 ? 1464 ASN A CB    1 
ATOM   5655 C  CG    . ASN A 1 1119 ? 125.750 146.382 121.585 1.00 125.96 ? 1464 ASN A CG    1 
ATOM   5656 O  OD1   . ASN A 1 1119 ? 125.407 146.170 122.748 1.00 125.52 ? 1464 ASN A OD1   1 
ATOM   5657 N  ND2   . ASN A 1 1119 ? 127.022 146.405 121.208 1.00 124.36 ? 1464 ASN A ND2   1 
ATOM   5658 N  N     . GLY A 1 1120 ? 121.474 146.311 119.350 1.00 130.34 ? 1465 GLY A N     1 
ATOM   5659 C  CA    . GLY A 1 1120 ? 120.554 146.888 118.390 1.00 129.61 ? 1465 GLY A CA    1 
ATOM   5660 C  C     . GLY A 1 1120 ? 121.268 147.379 117.141 1.00 129.68 ? 1465 GLY A C     1 
ATOM   5661 O  O     . GLY A 1 1120 ? 122.336 146.888 116.762 1.00 127.63 ? 1465 GLY A O     1 
ATOM   5662 N  N     . ARG A 1 1121 ? 120.660 148.366 116.491 1.00 133.87 ? 1466 ARG A N     1 
ATOM   5663 C  CA    . ARG A 1 1121 ? 121.205 148.979 115.291 1.00 133.59 ? 1466 ARG A CA    1 
ATOM   5664 C  C     . ARG A 1 1121 ? 121.535 150.440 115.562 1.00 133.66 ? 1466 ARG A C     1 
ATOM   5665 O  O     . ARG A 1 1121 ? 121.011 151.056 116.494 1.00 132.68 ? 1466 ARG A O     1 
ATOM   5666 C  CB    . ARG A 1 1121 ? 120.224 148.873 114.117 1.00 133.64 ? 1466 ARG A CB    1 
ATOM   5667 C  CG    . ARG A 1 1121 ? 119.267 147.697 114.212 1.00 133.72 ? 1466 ARG A CG    1 
ATOM   5668 C  CD    . ARG A 1 1121 ? 118.250 147.720 113.083 1.00 134.69 ? 1466 ARG A CD    1 
ATOM   5669 N  NE    . ARG A 1 1121 ? 118.885 147.677 111.771 1.00 136.38 ? 1466 ARG A NE    1 
ATOM   5670 C  CZ    . ARG A 1 1121 ? 119.298 146.568 111.173 1.00 134.45 ? 1466 ARG A CZ    1 
ATOM   5671 N  NH1   . ARG A 1 1121 ? 119.165 145.383 111.747 1.00 132.60 ? 1466 ARG A NH1   1 
ATOM   5672 N  NH2   . ARG A 1 1121 ? 119.856 146.649 109.969 1.00 133.61 ? 1466 ARG A NH2   1 
ATOM   5673 N  N     . SER A 1 1122 ? 122.415 150.992 114.732 1.00 129.40 ? 1467 SER A N     1 
ATOM   5674 C  CA    . SER A 1 1122 ? 122.820 152.381 114.873 1.00 128.42 ? 1467 SER A CA    1 
ATOM   5675 C  C     . SER A 1 1122 ? 121.747 153.304 114.298 1.00 129.11 ? 1467 SER A C     1 
ATOM   5676 O  O     . SER A 1 1122 ? 120.720 152.863 113.775 1.00 129.71 ? 1467 SER A O     1 
ATOM   5677 C  CB    . SER A 1 1122 ? 124.167 152.612 114.194 1.00 127.72 ? 1467 SER A CB    1 
ATOM   5678 O  OG    . SER A 1 1122 ? 124.013 152.759 112.793 1.00 127.64 ? 1467 SER A OG    1 
ATOM   5679 N  N     . SER A 1 1123 ? 121.990 154.613 114.402 1.00 128.02 ? 1468 SER A N     1 
ATOM   5680 C  CA    . SER A 1 1123 ? 121.041 155.586 113.871 1.00 127.34 ? 1468 SER A CA    1 
ATOM   5681 C  C     . SER A 1 1123 ? 120.953 155.502 112.352 1.00 128.67 ? 1468 SER A C     1 
ATOM   5682 O  O     . SER A 1 1123 ? 119.880 155.711 111.774 1.00 128.31 ? 1468 SER A O     1 
ATOM   5683 C  CB    . SER A 1 1123 ? 121.433 156.996 114.309 1.00 126.95 ? 1468 SER A CB    1 
ATOM   5684 O  OG    . SER A 1 1123 ? 122.435 157.531 113.462 1.00 127.09 ? 1468 SER A OG    1 
ATOM   5685 N  N     . SER A 1 1124 ? 122.069 155.200 111.690 1.00 128.70 ? 1469 SER A N     1 
ATOM   5686 C  CA    . SER A 1 1124 ? 122.090 155.093 110.237 1.00 128.24 ? 1469 SER A CA    1 
ATOM   5687 C  C     . SER A 1 1124 ? 121.537 153.768 109.730 1.00 128.53 ? 1469 SER A C     1 
ATOM   5688 O  O     . SER A 1 1124 ? 121.411 153.595 108.513 1.00 127.29 ? 1469 SER A O     1 
ATOM   5689 C  CB    . SER A 1 1124 ? 123.516 155.284 109.718 1.00 126.38 ? 1469 SER A CB    1 
ATOM   5690 O  OG    . SER A 1 1124 ? 124.104 156.450 110.266 1.00 125.01 ? 1469 SER A OG    1 
ATOM   5691 N  N     . GLY A 1 1125 ? 121.207 152.837 110.622 1.00 130.78 ? 1470 GLY A N     1 
ATOM   5692 C  CA    . GLY A 1 1125 ? 120.687 151.546 110.230 1.00 129.70 ? 1470 GLY A CA    1 
ATOM   5693 C  C     . GLY A 1 1125 ? 121.729 150.477 109.989 1.00 130.77 ? 1470 GLY A C     1 
ATOM   5694 O  O     . GLY A 1 1125 ? 121.360 149.321 109.746 1.00 131.58 ? 1470 GLY A O     1 
ATOM   5695 N  N     . ALA A 1 1126 ? 123.012 150.820 110.046 1.00 127.53 ? 1471 ALA A N     1 
ATOM   5696 C  CA    . ALA A 1 1126 ? 124.059 149.831 109.853 1.00 127.67 ? 1471 ALA A CA    1 
ATOM   5697 C  C     . ALA A 1 1126 ? 124.128 148.885 111.049 1.00 127.57 ? 1471 ALA A C     1 
ATOM   5698 O  O     . ALA A 1 1126 ? 123.687 149.202 112.157 1.00 126.65 ? 1471 ALA A O     1 
ATOM   5699 C  CB    . ALA A 1 1126 ? 125.411 150.513 109.641 1.00 126.94 ? 1471 ALA A CB    1 
ATOM   5700 N  N     . LEU A 1 1127 ? 124.691 147.706 110.808 1.00 117.21 ? 1472 LEU A N     1 
ATOM   5701 C  CA    . LEU A 1 1127 ? 124.798 146.696 111.845 1.00 116.20 ? 1472 LEU A CA    1 
ATOM   5702 C  C     . LEU A 1 1127 ? 125.949 147.019 112.796 1.00 115.51 ? 1472 LEU A C     1 
ATOM   5703 O  O     . LEU A 1 1127 ? 126.711 147.970 112.600 1.00 114.60 ? 1472 LEU A O     1 
ATOM   5704 C  CB    . LEU A 1 1127 ? 124.990 145.314 111.224 1.00 116.53 ? 1472 LEU A CB    1 
ATOM   5705 C  CG    . LEU A 1 1127 ? 123.996 144.932 110.127 1.00 117.62 ? 1472 LEU A CG    1 
ATOM   5706 C  CD1   . LEU A 1 1127 ? 124.391 143.619 109.475 1.00 115.69 ? 1472 LEU A CD1   1 
ATOM   5707 C  CD2   . LEU A 1 1127 ? 122.587 144.848 110.691 1.00 118.81 ? 1472 LEU A CD2   1 
ATOM   5708 N  N     . ARG A 1 1128 ? 126.065 146.210 113.847 1.00 115.03 ? 1473 ARG A N     1 
ATOM   5709 C  CA    . ARG A 1 1128 ? 127.135 146.357 114.824 1.00 114.44 ? 1473 ARG A CA    1 
ATOM   5710 C  C     . ARG A 1 1128 ? 127.867 145.064 115.145 1.00 117.24 ? 1473 ARG A C     1 
ATOM   5711 O  O     . ARG A 1 1128 ? 129.003 145.132 115.629 1.00 116.99 ? 1473 ARG A O     1 
ATOM   5712 C  CB    . ARG A 1 1128 ? 126.592 146.951 116.132 1.00 113.76 ? 1473 ARG A CB    1 
ATOM   5713 C  CG    . ARG A 1 1128 ? 126.225 148.420 116.041 1.00 114.97 ? 1473 ARG A CG    1 
ATOM   5714 C  CD    . ARG A 1 1128 ? 125.325 148.827 117.193 1.00 112.70 ? 1473 ARG A CD    1 
ATOM   5715 N  NE    . ARG A 1 1128 ? 125.087 150.265 117.224 1.00 112.86 ? 1473 ARG A NE    1 
ATOM   5716 C  CZ    . ARG A 1 1128 ? 124.222 150.862 118.031 1.00 115.01 ? 1473 ARG A CZ    1 
ATOM   5717 N  NH1   . ARG A 1 1128 ? 123.490 150.172 118.890 1.00 114.97 ? 1473 ARG A NH1   1 
ATOM   5718 N  NH2   . ARG A 1 1128 ? 124.089 152.183 117.977 1.00 116.13 ? 1473 ARG A NH2   1 
ATOM   5719 N  N     . GLY A 1 1129 ? 127.266 143.896 114.904 1.00 118.59 ? 1474 GLY A N     1 
ATOM   5720 C  CA    . GLY A 1 1129 ? 127.971 142.650 115.106 1.00 114.58 ? 1474 GLY A CA    1 
ATOM   5721 C  C     . GLY A 1 1129 ? 128.959 142.359 113.992 1.00 113.99 ? 1474 GLY A C     1 
ATOM   5722 O  O     . GLY A 1 1129 ? 128.847 142.859 112.874 1.00 115.11 ? 1474 GLY A O     1 
ATOM   5723 N  N     . VAL A 1 1130 ? 129.949 141.523 114.310 1.00 106.08 ? 1475 VAL A N     1 
ATOM   5724 C  CA    . VAL A 1 1130 ? 131.027 141.212 113.381 1.00 108.14 ? 1475 VAL A CA    1 
ATOM   5725 C  C     . VAL A 1 1130 ? 131.252 139.719 113.209 1.00 112.17 ? 1475 VAL A C     1 
ATOM   5726 O  O     . VAL A 1 1130 ? 132.118 139.326 112.427 1.00 110.64 ? 1475 VAL A O     1 
ATOM   5727 C  CB    . VAL A 1 1130 ? 132.342 141.897 113.805 1.00 106.47 ? 1475 VAL A CB    1 
ATOM   5728 C  CG1   . VAL A 1 1130 ? 132.305 143.371 113.463 1.00 106.79 ? 1475 VAL A CG1   1 
ATOM   5729 C  CG2   . VAL A 1 1130 ? 132.574 141.710 115.288 1.00 103.58 ? 1475 VAL A CG2   1 
ATOM   5730 N  N     . CYS A 1 1131 ? 130.503 138.870 113.906 1.00 129.25 ? 1476 CYS A N     1 
ATOM   5731 C  CA    . CYS A 1 1131 ? 130.729 137.433 113.824 1.00 128.49 ? 1476 CYS A CA    1 
ATOM   5732 C  C     . CYS A 1 1131 ? 129.441 136.701 114.167 1.00 127.58 ? 1476 CYS A C     1 
ATOM   5733 O  O     . CYS A 1 1131 ? 128.458 137.298 114.612 1.00 125.70 ? 1476 CYS A O     1 
ATOM   5734 C  CB    . CYS A 1 1131 ? 131.864 136.989 114.752 1.00 126.73 ? 1476 CYS A CB    1 
ATOM   5735 S  SG    . CYS A 1 1131 ? 132.404 135.282 114.501 1.00 125.65 ? 1476 CYS A SG    1 
ATOM   5736 N  N     . SER A 1 1132 ? 129.467 135.386 113.953 1.00 134.86 ? 1477 SER A N     1 
ATOM   5737 C  CA    . SER A 1 1132 ? 128.358 134.500 114.277 1.00 134.59 ? 1477 SER A CA    1 
ATOM   5738 C  C     . SER A 1 1132 ? 128.327 134.113 115.748 1.00 133.85 ? 1477 SER A C     1 
ATOM   5739 O  O     . SER A 1 1132 ? 127.679 133.120 116.102 1.00 133.95 ? 1477 SER A O     1 
ATOM   5740 C  CB    . SER A 1 1132 ? 128.420 133.242 113.408 1.00 134.04 ? 1477 SER A CB    1 
ATOM   5741 O  OG    . SER A 1 1132 ? 129.658 132.572 113.574 1.00 132.01 ? 1477 SER A OG    1 
ATOM   5742 N  N     . CYS A 1 1133 ? 129.024 134.866 116.603 1.00 131.98 ? 1478 CYS A N     1 
ATOM   5743 C  CA    . CYS A 1 1133 ? 129.066 134.540 118.024 1.00 133.45 ? 1478 CYS A CA    1 
ATOM   5744 C  C     . CYS A 1 1133 ? 127.675 134.584 118.643 1.00 134.26 ? 1478 CYS A C     1 
ATOM   5745 O  O     . CYS A 1 1133 ? 127.314 133.713 119.443 1.00 133.67 ? 1478 CYS A O     1 
ATOM   5746 C  CB    . CYS A 1 1133 ? 130.009 135.500 118.749 1.00 132.34 ? 1478 CYS A CB    1 
ATOM   5747 S  SG    . CYS A 1 1133 ? 131.751 135.308 118.306 1.00 135.17 ? 1478 CYS A SG    1 
ATOM   5748 N  N     . VAL A 1 1134 ? 126.881 135.588 118.286 1.00 135.01 ? 1479 VAL A N     1 
ATOM   5749 C  CA    . VAL A 1 1134 ? 125.520 135.701 118.789 1.00 135.30 ? 1479 VAL A CA    1 
ATOM   5750 C  C     . VAL A 1 1134 ? 124.526 135.322 117.698 1.00 134.26 ? 1479 VAL A C     1 
ATOM   5751 O  O     . VAL A 1 1134 ? 124.852 134.565 116.783 1.00 133.94 ? 1479 VAL A O     1 
ATOM   5752 C  CB    . VAL A 1 1134 ? 125.236 137.116 119.318 1.00 136.12 ? 1479 VAL A CB    1 
ATOM   5753 C  CG1   . VAL A 1 1134 ? 126.234 137.484 120.405 1.00 135.00 ? 1479 VAL A CG1   1 
ATOM   5754 C  CG2   . VAL A 1 1134 ? 125.281 138.125 118.180 1.00 136.15 ? 1479 VAL A CG2   1 
ATOM   5755 N  N     . ALA A 1 1139 ? 130.932 129.204 117.374 1.00 134.81 ? 1484 ALA A N     1 
ATOM   5756 C  CA    . ALA A 1 1139 ? 130.923 130.620 117.719 1.00 134.12 ? 1484 ALA A CA    1 
ATOM   5757 C  C     . ALA A 1 1139 ? 131.426 131.469 116.557 1.00 133.82 ? 1484 ALA A C     1 
ATOM   5758 O  O     . ALA A 1 1139 ? 130.808 132.468 116.193 1.00 129.33 ? 1484 ALA A O     1 
ATOM   5759 C  CB    . ALA A 1 1139 ? 131.766 130.869 118.960 1.00 132.71 ? 1484 ALA A CB    1 
ATOM   5760 N  N     . CYS A 1 1140 ? 132.552 131.066 115.976 1.00 144.31 ? 1485 CYS A N     1 
ATOM   5761 C  CA    . CYS A 1 1140 ? 133.166 131.784 114.866 1.00 143.98 ? 1485 CYS A CA    1 
ATOM   5762 C  C     . CYS A 1 1140 ? 133.282 130.855 113.668 1.00 144.07 ? 1485 CYS A C     1 
ATOM   5763 O  O     . CYS A 1 1140 ? 133.938 129.810 113.746 1.00 141.54 ? 1485 CYS A O     1 
ATOM   5764 C  CB    . CYS A 1 1140 ? 134.539 132.332 115.260 1.00 143.76 ? 1485 CYS A CB    1 
ATOM   5765 S  SG    . CYS A 1 1140 ? 134.580 133.108 116.889 1.00 147.36 ? 1485 CYS A SG    1 
ATOM   5766 N  N     . ASP A 1 1141 ? 132.645 131.236 112.567 1.00 143.66 ? 1486 ASP A N     1 
ATOM   5767 C  CA    . ASP A 1 1141 ? 132.746 130.509 111.316 1.00 142.86 ? 1486 ASP A CA    1 
ATOM   5768 C  C     . ASP A 1 1141 ? 134.092 130.784 110.651 1.00 141.70 ? 1486 ASP A C     1 
ATOM   5769 O  O     . ASP A 1 1141 ? 134.773 131.756 110.987 1.00 141.08 ? 1486 ASP A O     1 
ATOM   5770 C  CB    . ASP A 1 1141 ? 131.604 130.912 110.388 1.00 141.46 ? 1486 ASP A CB    1 
ATOM   5771 C  CG    . ASP A 1 1141 ? 130.247 130.795 111.053 1.00 141.75 ? 1486 ASP A CG    1 
ATOM   5772 O  OD1   . ASP A 1 1141 ? 130.162 130.158 112.124 1.00 141.84 ? 1486 ASP A OD1   1 
ATOM   5773 O  OD2   . ASP A 1 1141 ? 129.266 131.342 110.508 1.00 140.10 ? 1486 ASP A OD2   1 
ATOM   5774 N  N     . PRO A 1 1142 ? 134.513 129.928 109.719 1.00 137.80 ? 1487 PRO A N     1 
ATOM   5775 C  CA    . PRO A 1 1142 ? 135.735 130.220 108.962 1.00 137.55 ? 1487 PRO A CA    1 
ATOM   5776 C  C     . PRO A 1 1142 ? 135.603 131.517 108.178 1.00 137.72 ? 1487 PRO A C     1 
ATOM   5777 O  O     . PRO A 1 1142 ? 134.513 131.901 107.747 1.00 136.53 ? 1487 PRO A O     1 
ATOM   5778 C  CB    . PRO A 1 1142 ? 135.873 129.012 108.028 1.00 136.89 ? 1487 PRO A CB    1 
ATOM   5779 C  CG    . PRO A 1 1142 ? 135.138 127.918 108.719 1.00 136.11 ? 1487 PRO A CG    1 
ATOM   5780 C  CD    . PRO A 1 1142 ? 133.994 128.580 109.431 1.00 136.67 ? 1487 PRO A CD    1 
ATOM   5781 N  N     . ALA A 1 1143 ? 136.736 132.202 108.017 1.00 126.48 ? 1488 ALA A N     1 
ATOM   5782 C  CA    . ALA A 1 1143 ? 136.862 133.483 107.325 1.00 125.02 ? 1488 ALA A CA    1 
ATOM   5783 C  C     . ALA A 1 1143 ? 136.117 134.613 108.021 1.00 123.58 ? 1488 ALA A C     1 
ATOM   5784 O  O     . ALA A 1 1143 ? 135.960 135.692 107.436 1.00 121.33 ? 1488 ALA A O     1 
ATOM   5785 C  CB    . ALA A 1 1143 ? 136.403 133.395 105.864 1.00 124.29 ? 1488 ALA A CB    1 
ATOM   5786 N  N     . ALA A 1 1144 ? 135.647 134.401 109.253 1.00 117.42 ? 1489 ALA A N     1 
ATOM   5787 C  CA    . ALA A 1 1144 ? 135.027 135.490 110.001 1.00 117.02 ? 1489 ALA A CA    1 
ATOM   5788 C  C     . ALA A 1 1144 ? 136.059 136.532 110.409 1.00 115.98 ? 1489 ALA A C     1 
ATOM   5789 O  O     . ALA A 1 1144 ? 135.755 137.730 110.455 1.00 113.92 ? 1489 ALA A O     1 
ATOM   5790 C  CB    . ALA A 1 1144 ? 134.301 134.943 111.228 1.00 115.21 ? 1489 ALA A CB    1 
ATOM   5791 N  N     . ARG A 1 1145 ? 137.277 136.095 110.718 1.00 104.98 ? 1490 ARG A N     1 
ATOM   5792 C  CA    . ARG A 1 1145 ? 138.342 137.027 111.058 1.00 103.26 ? 1490 ARG A CA    1 
ATOM   5793 C  C     . ARG A 1 1145 ? 138.699 137.883 109.850 1.00 103.19 ? 1490 ARG A C     1 
ATOM   5794 O  O     . ARG A 1 1145 ? 138.826 137.378 108.731 1.00 101.47 ? 1490 ARG A O     1 
ATOM   5795 C  CB    . ARG A 1 1145 ? 139.572 136.265 111.551 1.00 102.94 ? 1490 ARG A CB    1 
ATOM   5796 C  CG    . ARG A 1 1145 ? 139.290 135.293 112.682 1.00 102.80 ? 1490 ARG A CG    1 
ATOM   5797 C  CD    . ARG A 1 1145 ? 140.562 134.939 113.435 1.00 104.85 ? 1490 ARG A CD    1 
ATOM   5798 N  NE    . ARG A 1 1145 ? 141.512 136.045 113.450 1.00 107.02 ? 1490 ARG A NE    1 
ATOM   5799 C  CZ    . ARG A 1 1145 ? 142.825 135.908 113.330 1.00 104.20 ? 1490 ARG A CZ    1 
ATOM   5800 N  NH1   . ARG A 1 1145 ? 143.385 134.719 113.180 1.00 103.51 ? 1490 ARG A NH1   1 
ATOM   5801 N  NH2   . ARG A 1 1145 ? 143.596 136.991 113.361 1.00 101.67 ? 1490 ARG A NH2   1 
ATOM   5802 N  N     . GLN A 1 1146 ? 138.859 139.183 110.080 1.00 90.66  ? 1491 GLN A N     1 
ATOM   5803 C  CA    . GLN A 1 1146 ? 139.221 140.131 109.035 1.00 86.00  ? 1491 GLN A CA    1 
ATOM   5804 C  C     . GLN A 1 1146 ? 140.506 140.834 109.440 1.00 83.46  ? 1491 GLN A C     1 
ATOM   5805 O  O     . GLN A 1 1146 ? 140.589 141.403 110.534 1.00 84.67  ? 1491 GLN A O     1 
ATOM   5806 C  CB    . GLN A 1 1146 ? 138.100 141.144 108.800 1.00 87.04  ? 1491 GLN A CB    1 
ATOM   5807 C  CG    . GLN A 1 1146 ? 136.749 140.510 108.529 1.00 89.48  ? 1491 GLN A CG    1 
ATOM   5808 C  CD    . GLN A 1 1146 ? 135.604 141.479 108.727 1.00 90.51  ? 1491 GLN A CD    1 
ATOM   5809 O  OE1   . GLN A 1 1146 ? 135.446 142.434 107.968 1.00 89.08  ? 1491 GLN A OE1   1 
ATOM   5810 N  NE2   . GLN A 1 1146 ? 134.797 141.239 109.753 1.00 89.66  ? 1491 GLN A NE2   1 
ATOM   5811 N  N     . PHE A 1 1147 ? 141.500 140.797 108.562 1.00 85.33  ? 1492 PHE A N     1 
ATOM   5812 C  CA    . PHE A 1 1147 ? 142.799 141.395 108.821 1.00 87.20  ? 1492 PHE A CA    1 
ATOM   5813 C  C     . PHE A 1 1147 ? 142.953 142.692 108.036 1.00 88.28  ? 1492 PHE A C     1 
ATOM   5814 O  O     . PHE A 1 1147 ? 142.134 143.033 107.179 1.00 91.68  ? 1492 PHE A O     1 
ATOM   5815 C  CB    . PHE A 1 1147 ? 143.920 140.416 108.458 1.00 91.44  ? 1492 PHE A CB    1 
ATOM   5816 C  CG    . PHE A 1 1147 ? 143.563 138.974 108.681 1.00 91.35  ? 1492 PHE A CG    1 
ATOM   5817 C  CD1   . PHE A 1 1147 ? 143.246 138.512 109.947 1.00 89.21  ? 1492 PHE A CD1   1 
ATOM   5818 C  CD2   . PHE A 1 1147 ? 143.544 138.082 107.624 1.00 90.80  ? 1492 PHE A CD2   1 
ATOM   5819 C  CE1   . PHE A 1 1147 ? 142.918 137.187 110.153 1.00 88.73  ? 1492 PHE A CE1   1 
ATOM   5820 C  CE2   . PHE A 1 1147 ? 143.216 136.756 107.824 1.00 90.01  ? 1492 PHE A CE2   1 
ATOM   5821 C  CZ    . PHE A 1 1147 ? 142.903 136.308 109.090 1.00 90.50  ? 1492 PHE A CZ    1 
ATOM   5822 N  N     . ASN A 1 1148 ? 144.028 143.417 108.344 1.00 80.67  ? 1493 ASN A N     1 
ATOM   5823 C  CA    . ASN A 1 1148 ? 144.378 144.659 107.656 1.00 80.80  ? 1493 ASN A CA    1 
ATOM   5824 C  C     . ASN A 1 1148 ? 143.236 145.675 107.731 1.00 86.07  ? 1493 ASN A C     1 
ATOM   5825 O  O     . ASN A 1 1148 ? 142.725 146.156 106.719 1.00 91.54  ? 1493 ASN A O     1 
ATOM   5826 C  CB    . ASN A 1 1148 ? 144.775 144.384 106.202 1.00 84.34  ? 1493 ASN A CB    1 
ATOM   5827 C  CG    . ASN A 1 1148 ? 146.274 144.365 106.004 1.00 90.12  ? 1493 ASN A CG    1 
ATOM   5828 O  OD1   . ASN A 1 1148 ? 147.038 144.360 106.968 1.00 89.88  ? 1493 ASN A OD1   1 
ATOM   5829 N  ND2   . ASN A 1 1148 ? 146.705 144.357 104.748 1.00 90.69  ? 1493 ASN A ND2   1 
ATOM   5830 N  N     . THR A 1 1149 ? 142.837 145.990 108.960 1.00 68.29  ? 1494 THR A N     1 
ATOM   5831 C  CA    . THR A 1 1149 ? 141.819 146.998 109.218 1.00 59.73  ? 1494 THR A CA    1 
ATOM   5832 C  C     . THR A 1 1149 ? 142.322 147.961 110.279 1.00 58.39  ? 1494 THR A C     1 
ATOM   5833 O  O     . THR A 1 1149 ? 143.036 147.562 111.203 1.00 55.14  ? 1494 THR A O     1 
ATOM   5834 C  CB    . THR A 1 1149 ? 140.501 146.373 109.682 1.00 56.71  ? 1494 THR A CB    1 
ATOM   5835 O  OG1   . THR A 1 1149 ? 140.703 145.701 110.931 1.00 65.03  ? 1494 THR A OG1   1 
ATOM   5836 C  CG2   . THR A 1 1149 ? 139.990 145.379 108.657 1.00 63.08  ? 1494 THR A CG2   1 
ATOM   5837 N  N     . LEU A 1 1150 ? 141.954 149.236 110.137 1.00 56.70  ? 1495 LEU A N     1 
ATOM   5838 C  CA    . LEU A 1 1150 ? 142.299 150.214 111.161 1.00 61.12  ? 1495 LEU A CA    1 
ATOM   5839 C  C     . LEU A 1 1150 ? 141.626 149.875 112.484 1.00 63.39  ? 1495 LEU A C     1 
ATOM   5840 O  O     . LEU A 1 1150 ? 142.255 149.944 113.546 1.00 64.25  ? 1495 LEU A O     1 
ATOM   5841 C  CB    . LEU A 1 1150 ? 141.911 151.617 110.698 1.00 56.96  ? 1495 LEU A CB    1 
ATOM   5842 C  CG    . LEU A 1 1150 ? 142.701 152.777 111.303 1.00 59.14  ? 1495 LEU A CG    1 
ATOM   5843 C  CD1   . LEU A 1 1150 ? 144.190 152.494 111.282 1.00 60.04  ? 1495 LEU A CD1   1 
ATOM   5844 C  CD2   . LEU A 1 1150 ? 142.400 154.061 110.560 1.00 63.06  ? 1495 LEU A CD2   1 
ATOM   5845 N  N     . ILE A 1 1151 ? 140.356 149.502 112.441 1.00 65.57  ? 1496 ILE A N     1 
ATOM   5846 C  CA    . ILE A 1 1151 ? 139.660 149.040 113.642 1.00 60.44  ? 1496 ILE A CA    1 
ATOM   5847 C  C     . ILE A 1 1151 ? 140.020 147.576 113.881 1.00 67.91  ? 1496 ILE A C     1 
ATOM   5848 O  O     . ILE A 1 1151 ? 139.851 146.751 112.970 1.00 69.89  ? 1496 ILE A O     1 
ATOM   5849 C  CB    . ILE A 1 1151 ? 138.155 149.214 113.489 1.00 57.12  ? 1496 ILE A CB    1 
ATOM   5850 C  CG1   . ILE A 1 1151 ? 137.806 150.688 113.318 1.00 60.59  ? 1496 ILE A CG1   1 
ATOM   5851 C  CG2   . ILE A 1 1151 ? 137.431 148.653 114.694 1.00 58.58  ? 1496 ILE A CG2   1 
ATOM   5852 C  CD1   . ILE A 1 1151 ? 136.326 150.953 113.317 1.00 66.47  ? 1496 ILE A CD1   1 
ATOM   5853 N  N     . PRO A 1 1152 ? 140.517 147.219 115.063 1.00 56.53  ? 1497 PRO A N     1 
ATOM   5854 C  CA    . PRO A 1 1152 ? 140.774 145.806 115.354 1.00 53.17  ? 1497 PRO A CA    1 
ATOM   5855 C  C     . PRO A 1 1152 ? 139.484 145.006 115.285 1.00 61.13  ? 1497 PRO A C     1 
ATOM   5856 O  O     . PRO A 1 1152 ? 138.391 145.542 115.462 1.00 72.31  ? 1497 PRO A O     1 
ATOM   5857 C  CB    . PRO A 1 1152 ? 141.341 145.833 116.777 1.00 47.29  ? 1497 PRO A CB    1 
ATOM   5858 C  CG    . PRO A 1 1152 ? 141.830 147.227 116.966 1.00 50.29  ? 1497 PRO A CG    1 
ATOM   5859 C  CD    . PRO A 1 1152 ? 140.907 148.093 116.179 1.00 51.68  ? 1497 PRO A CD    1 
ATOM   5860 N  N     . TRP A 1 1153 ? 139.613 143.716 114.984 1.00 68.75  ? 1498 TRP A N     1 
ATOM   5861 C  CA    . TRP A 1 1153 ? 138.429 142.870 114.892 1.00 71.34  ? 1498 TRP A CA    1 
ATOM   5862 C  C     . TRP A 1 1153 ? 138.027 142.278 116.237 1.00 76.10  ? 1498 TRP A C     1 
ATOM   5863 O  O     . TRP A 1 1153 ? 136.831 142.192 116.548 1.00 81.37  ? 1498 TRP A O     1 
ATOM   5864 C  CB    . TRP A 1 1153 ? 138.662 141.745 113.883 1.00 71.23  ? 1498 TRP A CB    1 
ATOM   5865 C  CG    . TRP A 1 1153 ? 137.547 140.759 113.843 1.00 74.95  ? 1498 TRP A CG    1 
ATOM   5866 C  CD1   . TRP A 1 1153 ? 136.409 140.842 113.099 1.00 77.33  ? 1498 TRP A CD1   1 
ATOM   5867 C  CD2   . TRP A 1 1153 ? 137.455 139.537 114.581 1.00 78.33  ? 1498 TRP A CD2   1 
ATOM   5868 N  NE1   . TRP A 1 1153 ? 135.613 139.748 113.327 1.00 80.47  ? 1498 TRP A NE1   1 
ATOM   5869 C  CE2   . TRP A 1 1153 ? 136.234 138.931 114.235 1.00 80.43  ? 1498 TRP A CE2   1 
ATOM   5870 C  CE3   . TRP A 1 1153 ? 138.288 138.898 115.503 1.00 77.75  ? 1498 TRP A CE3   1 
ATOM   5871 C  CZ2   . TRP A 1 1153 ? 135.825 137.716 114.776 1.00 78.98  ? 1498 TRP A CZ2   1 
ATOM   5872 C  CZ3   . TRP A 1 1153 ? 137.880 137.693 116.039 1.00 77.87  ? 1498 TRP A CZ3   1 
ATOM   5873 C  CH2   . TRP A 1 1153 ? 136.660 137.115 115.674 1.00 77.33  ? 1498 TRP A CH2   1 
ATOM   5874 N  N     . CYS A 1 1154 ? 139.009 141.879 117.048 1.00 64.85  ? 1499 CYS A N     1 
ATOM   5875 C  CA    . CYS A 1 1154 ? 138.706 141.187 118.295 1.00 63.84  ? 1499 CYS A CA    1 
ATOM   5876 C  C     . CYS A 1 1154 ? 137.919 142.072 119.251 1.00 69.24  ? 1499 CYS A C     1 
ATOM   5877 O  O     . CYS A 1 1154 ? 136.997 141.598 119.926 1.00 74.32  ? 1499 CYS A O     1 
ATOM   5878 C  CB    . CYS A 1 1154 ? 139.999 140.707 118.952 1.00 65.90  ? 1499 CYS A CB    1 
ATOM   5879 S  SG    . CYS A 1 1154 ? 141.208 142.004 119.255 1.00 64.12  ? 1499 CYS A SG    1 
ATOM   5880 N  N     . LEU A 1 1155 ? 138.277 143.354 119.340 1.00 57.81  ? 1500 LEU A N     1 
ATOM   5881 C  CA    . LEU A 1 1155 ? 137.610 144.233 120.298 1.00 52.13  ? 1500 LEU A CA    1 
ATOM   5882 C  C     . LEU A 1 1155 ? 136.126 144.405 119.995 1.00 53.52  ? 1500 LEU A C     1 
ATOM   5883 O  O     . LEU A 1 1155 ? 135.317 144.297 120.931 1.00 59.84  ? 1500 LEU A O     1 
ATOM   5884 C  CB    . LEU A 1 1155 ? 138.353 145.571 120.379 1.00 49.74  ? 1500 LEU A CB    1 
ATOM   5885 C  CG    . LEU A 1 1155 ? 139.879 145.494 120.343 1.00 51.91  ? 1500 LEU A CG    1 
ATOM   5886 C  CD1   . LEU A 1 1155 ? 140.489 146.877 120.376 1.00 63.25  ? 1500 LEU A CD1   1 
ATOM   5887 C  CD2   . LEU A 1 1155 ? 140.391 144.672 121.498 1.00 52.91  ? 1500 LEU A CD2   1 
ATOM   5888 N  N     . PRO A 1 1156 ? 135.694 144.683 118.759 1.00 51.80  ? 1501 PRO A N     1 
ATOM   5889 C  CA    . PRO A 1 1156 ? 134.258 144.557 118.467 1.00 56.75  ? 1501 PRO A CA    1 
ATOM   5890 C  C     . PRO A 1 1156 ? 133.721 143.155 118.672 1.00 67.17  ? 1501 PRO A C     1 
ATOM   5891 O  O     . PRO A 1 1156 ? 132.561 143.006 119.077 1.00 70.00  ? 1501 PRO A O     1 
ATOM   5892 C  CB    . PRO A 1 1156 ? 134.143 144.979 116.995 1.00 53.28  ? 1501 PRO A CB    1 
ATOM   5893 C  CG    . PRO A 1 1156 ? 135.421 145.569 116.620 1.00 52.50  ? 1501 PRO A CG    1 
ATOM   5894 C  CD    . PRO A 1 1156 ? 136.390 145.484 117.741 1.00 55.10  ? 1501 PRO A CD    1 
ATOM   5895 N  N     . HIS A 1 1157 ? 134.518 142.118 118.395 1.00 79.46  ? 1502 HIS A N     1 
ATOM   5896 C  CA    . HIS A 1 1157 ? 133.993 140.757 118.473 1.00 76.91  ? 1502 HIS A CA    1 
ATOM   5897 C  C     . HIS A 1 1157 ? 133.568 140.394 119.890 1.00 75.81  ? 1502 HIS A C     1 
ATOM   5898 O  O     . HIS A 1 1157 ? 132.512 139.783 120.089 1.00 74.25  ? 1502 HIS A O     1 
ATOM   5899 C  CB    . HIS A 1 1157 ? 135.027 139.757 117.961 1.00 76.44  ? 1502 HIS A CB    1 
ATOM   5900 C  CG    . HIS A 1 1157 ? 134.604 138.329 118.112 1.00 79.31  ? 1502 HIS A CG    1 
ATOM   5901 N  ND1   . HIS A 1 1157 ? 135.408 137.370 118.689 1.00 78.06  ? 1502 HIS A ND1   1 
ATOM   5902 C  CD2   . HIS A 1 1157 ? 133.454 137.701 117.773 1.00 83.34  ? 1502 HIS A CD2   1 
ATOM   5903 C  CE1   . HIS A 1 1157 ? 134.775 136.211 118.691 1.00 78.97  ? 1502 HIS A CE1   1 
ATOM   5904 N  NE2   . HIS A 1 1157 ? 133.586 136.385 118.142 1.00 85.18  ? 1502 HIS A NE2   1 
ATOM   5905 N  N     . THR A 1 1158 ? 134.373 140.757 120.888 1.00 69.39  ? 1503 THR A N     1 
ATOM   5906 C  CA    . THR A 1 1158 ? 134.121 140.323 122.258 1.00 68.25  ? 1503 THR A CA    1 
ATOM   5907 C  C     . THR A 1 1158 ? 134.093 141.494 123.233 1.00 69.93  ? 1503 THR A C     1 
ATOM   5908 O  O     . THR A 1 1158 ? 134.390 141.328 124.417 1.00 74.04  ? 1503 THR A O     1 
ATOM   5909 C  CB    . THR A 1 1158 ? 135.159 139.294 122.703 1.00 71.07  ? 1503 THR A CB    1 
ATOM   5910 O  OG1   . THR A 1 1158 ? 134.865 138.867 124.038 1.00 74.35  ? 1503 THR A OG1   1 
ATOM   5911 C  CG2   . THR A 1 1158 ? 136.559 139.890 122.662 1.00 67.81  ? 1503 THR A CG2   1 
ATOM   5912 N  N     . GLY A 1 1159 ? 133.729 142.685 122.759 1.00 64.48  ? 1504 GLY A N     1 
ATOM   5913 C  CA    . GLY A 1 1159 ? 133.703 143.837 123.642 1.00 62.41  ? 1504 GLY A CA    1 
ATOM   5914 C  C     . GLY A 1 1159 ? 132.517 143.855 124.584 1.00 63.77  ? 1504 GLY A C     1 
ATOM   5915 O  O     . GLY A 1 1159 ? 132.587 144.456 125.659 1.00 64.97  ? 1504 GLY A O     1 
ATOM   5916 N  N     . ASN A 1 1160 ? 131.421 143.196 124.205 1.00 72.25  ? 1505 ASN A N     1 
ATOM   5917 C  CA    . ASN A 1 1160 ? 130.200 143.277 125.001 1.00 69.85  ? 1505 ASN A CA    1 
ATOM   5918 C  C     . ASN A 1 1160 ? 130.399 142.690 126.392 1.00 73.68  ? 1505 ASN A C     1 
ATOM   5919 O  O     . ASN A 1 1160 ? 129.908 143.243 127.382 1.00 78.80  ? 1505 ASN A O     1 
ATOM   5920 C  CB    . ASN A 1 1160 ? 129.057 142.569 124.279 1.00 73.36  ? 1505 ASN A CB    1 
ATOM   5921 C  CG    . ASN A 1 1160 ? 128.729 143.208 122.949 1.00 78.82  ? 1505 ASN A CG    1 
ATOM   5922 O  OD1   . ASN A 1 1160 ? 129.078 144.361 122.701 1.00 79.84  ? 1505 ASN A OD1   1 
ATOM   5923 N  ND2   . ASN A 1 1160 ? 128.055 142.462 122.084 1.00 80.31  ? 1505 ASN A ND2   1 
ATOM   5924 N  N     . ARG A 1 1161 ? 131.116 141.572 126.490 1.00 72.31  ? 1506 ARG A N     1 
ATOM   5925 C  CA    . ARG A 1 1161 ? 131.327 140.893 127.760 1.00 76.61  ? 1506 ARG A CA    1 
ATOM   5926 C  C     . ARG A 1 1161 ? 132.696 141.189 128.363 1.00 77.73  ? 1506 ARG A C     1 
ATOM   5927 O  O     . ARG A 1 1161 ? 133.198 140.391 129.160 1.00 77.22  ? 1506 ARG A O     1 
ATOM   5928 C  CB    . ARG A 1 1161 ? 131.141 139.385 127.590 1.00 72.35  ? 1506 ARG A CB    1 
ATOM   5929 C  CG    . ARG A 1 1161 ? 132.035 138.765 126.533 1.00 72.77  ? 1506 ARG A CG    1 
ATOM   5930 C  CD    . ARG A 1 1161 ? 131.943 137.249 126.554 1.00 73.92  ? 1506 ARG A CD    1 
ATOM   5931 N  NE    . ARG A 1 1161 ? 132.956 136.631 125.708 1.00 73.81  ? 1506 ARG A NE    1 
ATOM   5932 C  CZ    . ARG A 1 1161 ? 132.711 136.086 124.525 1.00 74.99  ? 1506 ARG A CZ    1 
ATOM   5933 N  NH1   . ARG A 1 1161 ? 131.491 136.060 124.015 1.00 77.21  ? 1506 ARG A NH1   1 
ATOM   5934 N  NH2   . ARG A 1 1161 ? 133.716 135.552 123.837 1.00 69.60  ? 1506 ARG A NH2   1 
ATOM   5935 N  N     . HIS A 1 1162 ? 133.314 142.313 127.995 1.00 66.94  ? 1507 HIS A N     1 
ATOM   5936 C  CA    . HIS A 1 1162 ? 134.615 142.668 128.547 1.00 61.91  ? 1507 HIS A CA    1 
ATOM   5937 C  C     . HIS A 1 1162 ? 134.722 144.162 128.825 1.00 59.87  ? 1507 HIS A C     1 
ATOM   5938 O  O     . HIS A 1 1162 ? 135.814 144.733 128.741 1.00 60.84  ? 1507 HIS A O     1 
ATOM   5939 C  CB    . HIS A 1 1162 ? 135.740 142.231 127.615 1.00 64.57  ? 1507 HIS A CB    1 
ATOM   5940 C  CG    . HIS A 1 1162 ? 136.101 140.786 127.744 1.00 63.94  ? 1507 HIS A CG    1 
ATOM   5941 N  ND1   . HIS A 1 1162 ? 137.041 140.332 128.643 1.00 66.71  ? 1507 HIS A ND1   1 
ATOM   5942 C  CD2   . HIS A 1 1162 ? 135.649 139.692 127.088 1.00 65.73  ? 1507 HIS A CD2   1 
ATOM   5943 C  CE1   . HIS A 1 1162 ? 137.154 139.021 128.534 1.00 68.92  ? 1507 HIS A CE1   1 
ATOM   5944 N  NE2   . HIS A 1 1162 ? 136.319 138.608 127.598 1.00 69.07  ? 1507 HIS A NE2   1 
ATOM   5945 N  N     . ASN A 1 1163 ? 133.602 144.805 129.157 1.00 62.16  ? 1508 ASN A N     1 
ATOM   5946 C  CA    . ASN A 1 1163 ? 133.563 146.238 129.455 1.00 65.30  ? 1508 ASN A CA    1 
ATOM   5947 C  C     . ASN A 1 1163 ? 134.003 147.075 128.255 1.00 69.49  ? 1508 ASN A C     1 
ATOM   5948 O  O     . ASN A 1 1163 ? 134.709 148.075 128.400 1.00 71.62  ? 1508 ASN A O     1 
ATOM   5949 C  CB    . ASN A 1 1163 ? 134.408 146.574 130.685 1.00 61.48  ? 1508 ASN A CB    1 
ATOM   5950 C  CG    . ASN A 1 1163 ? 134.061 147.920 131.272 1.00 66.63  ? 1508 ASN A CG    1 
ATOM   5951 O  OD1   . ASN A 1 1163 ? 132.891 148.287 131.352 1.00 65.73  ? 1508 ASN A OD1   1 
ATOM   5952 N  ND2   . ASN A 1 1163 ? 135.078 148.672 131.673 1.00 69.65  ? 1508 ASN A ND2   1 
ATOM   5953 N  N     . HIS A 1 1164 ? 133.593 146.657 127.059 1.00 65.92  ? 1509 HIS A N     1 
ATOM   5954 C  CA    . HIS A 1 1164 ? 133.830 147.398 125.821 1.00 53.87  ? 1509 HIS A CA    1 
ATOM   5955 C  C     . HIS A 1 1164 ? 135.309 147.657 125.565 1.00 59.23  ? 1509 HIS A C     1 
ATOM   5956 O  O     . HIS A 1 1164 ? 135.657 148.538 124.774 1.00 60.86  ? 1509 HIS A O     1 
ATOM   5957 C  CB    . HIS A 1 1164 ? 133.055 148.717 125.817 1.00 52.31  ? 1509 HIS A CB    1 
ATOM   5958 C  CG    . HIS A 1 1164 ? 131.601 148.557 126.128 1.00 63.03  ? 1509 HIS A CG    1 
ATOM   5959 N  ND1   . HIS A 1 1164 ? 130.722 147.938 125.268 1.00 64.37  ? 1509 HIS A ND1   1 
ATOM   5960 C  CD2   . HIS A 1 1164 ? 130.874 148.927 127.208 1.00 65.31  ? 1509 HIS A CD2   1 
ATOM   5961 C  CE1   . HIS A 1 1164 ? 129.514 147.937 125.801 1.00 63.72  ? 1509 HIS A CE1   1 
ATOM   5962 N  NE2   . HIS A 1 1164 ? 129.579 148.531 126.979 1.00 64.43  ? 1509 HIS A NE2   1 
ATOM   5963 N  N     . TRP A 1 1165 ? 136.183 146.895 126.220 1.00 61.75  ? 1510 TRP A N     1 
ATOM   5964 C  CA    . TRP A 1 1165 ? 137.629 147.003 126.046 1.00 52.03  ? 1510 TRP A CA    1 
ATOM   5965 C  C     . TRP A 1 1165 ? 138.107 148.433 126.276 1.00 46.06  ? 1510 TRP A C     1 
ATOM   5966 O  O     . TRP A 1 1165 ? 138.889 148.988 125.504 1.00 49.22  ? 1510 TRP A O     1 
ATOM   5967 C  CB    . TRP A 1 1165 ? 138.051 146.495 124.670 1.00 54.22  ? 1510 TRP A CB    1 
ATOM   5968 C  CG    . TRP A 1 1165 ? 137.911 145.022 124.529 1.00 45.64  ? 1510 TRP A CG    1 
ATOM   5969 C  CD1   . TRP A 1 1165 ? 137.088 144.357 123.677 1.00 42.38  ? 1510 TRP A CD1   1 
ATOM   5970 C  CD2   . TRP A 1 1165 ? 138.610 144.023 125.274 1.00 49.52  ? 1510 TRP A CD2   1 
ATOM   5971 N  NE1   . TRP A 1 1165 ? 137.231 143.003 123.840 1.00 49.73  ? 1510 TRP A NE1   1 
ATOM   5972 C  CE2   . TRP A 1 1165 ? 138.163 142.773 124.816 1.00 52.79  ? 1510 TRP A CE2   1 
ATOM   5973 C  CE3   . TRP A 1 1165 ? 139.574 144.065 126.285 1.00 57.48  ? 1510 TRP A CE3   1 
ATOM   5974 C  CZ2   . TRP A 1 1165 ? 138.644 141.576 125.331 1.00 59.68  ? 1510 TRP A CZ2   1 
ATOM   5975 C  CZ3   . TRP A 1 1165 ? 140.049 142.878 126.796 1.00 59.51  ? 1510 TRP A CZ3   1 
ATOM   5976 C  CH2   . TRP A 1 1165 ? 139.586 141.650 126.319 1.00 61.17  ? 1510 TRP A CH2   1 
ATOM   5977 N  N     . ALA A 1 1166 ? 137.611 149.035 127.351 1.00 46.66  ? 1511 ALA A N     1 
ATOM   5978 C  CA    . ALA A 1 1166 ? 138.043 150.376 127.708 1.00 50.65  ? 1511 ALA A CA    1 
ATOM   5979 C  C     . ALA A 1 1166 ? 139.532 150.383 128.019 1.00 51.73  ? 1511 ALA A C     1 
ATOM   5980 O  O     . ALA A 1 1166 ? 140.046 149.490 128.695 1.00 58.66  ? 1511 ALA A O     1 
ATOM   5981 C  CB    . ALA A 1 1166 ? 137.249 150.886 128.909 1.00 54.80  ? 1511 ALA A CB    1 
ATOM   5982 N  N     . GLY A 1 1167 ? 140.227 151.397 127.516 1.00 48.06  ? 1512 GLY A N     1 
ATOM   5983 C  CA    . GLY A 1 1167 ? 141.643 151.524 127.769 1.00 52.81  ? 1512 GLY A CA    1 
ATOM   5984 C  C     . GLY A 1 1167 ? 142.545 150.714 126.867 1.00 56.67  ? 1512 GLY A C     1 
ATOM   5985 O  O     . GLY A 1 1167 ? 143.728 150.559 127.188 1.00 56.64  ? 1512 GLY A O     1 
ATOM   5986 N  N     . LEU A 1 1168 ? 142.035 150.184 125.760 1.00 46.54  ? 1513 LEU A N     1 
ATOM   5987 C  CA    . LEU A 1 1168 ? 142.863 149.497 124.779 1.00 44.12  ? 1513 LEU A CA    1 
ATOM   5988 C  C     . LEU A 1 1168 ? 143.208 150.470 123.662 1.00 44.13  ? 1513 LEU A C     1 
ATOM   5989 O  O     . LEU A 1 1168 ? 142.328 151.173 123.157 1.00 54.71  ? 1513 LEU A O     1 
ATOM   5990 C  CB    . LEU A 1 1168 ? 142.156 148.267 124.212 1.00 48.22  ? 1513 LEU A CB    1 
ATOM   5991 C  CG    . LEU A 1 1168 ? 141.963 147.098 125.178 1.00 46.74  ? 1513 LEU A CG    1 
ATOM   5992 C  CD1   . LEU A 1 1168 ? 142.011 145.775 124.441 1.00 37.49  ? 1513 LEU A CD1   1 
ATOM   5993 C  CD2   . LEU A 1 1168 ? 142.985 147.135 126.294 1.00 47.63  ? 1513 LEU A CD2   1 
ATOM   5994 N  N     . TYR A 1 1169 ? 144.487 150.508 123.285 1.00 37.20  ? 1514 TYR A N     1 
ATOM   5995 C  CA    . TYR A 1 1169 ? 145.024 151.533 122.391 1.00 38.10  ? 1514 TYR A CA    1 
ATOM   5996 C  C     . TYR A 1 1169 ? 144.877 152.924 122.997 1.00 44.58  ? 1514 TYR A C     1 
ATOM   5997 O  O     . TYR A 1 1169 ? 144.821 153.924 122.279 1.00 49.37  ? 1514 TYR A O     1 
ATOM   5998 C  CB    . TYR A 1 1169 ? 144.366 151.483 121.008 1.00 38.46  ? 1514 TYR A CB    1 
ATOM   5999 C  CG    . TYR A 1 1169 ? 144.997 150.497 120.060 1.00 36.23  ? 1514 TYR A CG    1 
ATOM   6000 C  CD1   . TYR A 1 1169 ? 146.130 150.831 119.340 1.00 42.75  ? 1514 TYR A CD1   1 
ATOM   6001 C  CD2   . TYR A 1 1169 ? 144.459 149.235 119.883 1.00 47.89  ? 1514 TYR A CD2   1 
ATOM   6002 C  CE1   . TYR A 1 1169 ? 146.712 149.938 118.475 1.00 48.10  ? 1514 TYR A CE1   1 
ATOM   6003 C  CE2   . TYR A 1 1169 ? 145.034 148.334 119.020 1.00 50.39  ? 1514 TYR A CE2   1 
ATOM   6004 C  CZ    . TYR A 1 1169 ? 146.161 148.691 118.317 1.00 47.89  ? 1514 TYR A CZ    1 
ATOM   6005 O  OH    . TYR A 1 1169 ? 146.743 147.796 117.452 1.00 46.33  ? 1514 TYR A OH    1 
ATOM   6006 N  N     . GLY A 1 1170 ? 144.822 152.997 124.324 1.00 37.09  ? 1515 GLY A N     1 
ATOM   6007 C  CA    . GLY A 1 1170 ? 144.538 154.249 124.984 1.00 33.19  ? 1515 GLY A CA    1 
ATOM   6008 C  C     . GLY A 1 1170 ? 145.745 155.154 125.093 1.00 28.78  ? 1515 GLY A C     1 
ATOM   6009 O  O     . GLY A 1 1170 ? 146.892 154.735 124.972 1.00 38.38  ? 1515 GLY A O     1 
ATOM   6010 N  N     . ARG A 1 1171 ? 145.466 156.429 125.333 1.00 36.90  ? 1516 ARG A N     1 
ATOM   6011 C  CA    . ARG A 1 1171 ? 146.487 157.453 125.490 1.00 36.79  ? 1516 ARG A CA    1 
ATOM   6012 C  C     . ARG A 1 1171 ? 146.510 157.923 126.934 1.00 36.96  ? 1516 ARG A C     1 
ATOM   6013 O  O     . ARG A 1 1171 ? 145.461 158.245 127.500 1.00 49.92  ? 1516 ARG A O     1 
ATOM   6014 C  CB    . ARG A 1 1171 ? 146.217 158.641 124.566 1.00 38.99  ? 1516 ARG A CB    1 
ATOM   6015 C  CG    . ARG A 1 1171 ? 146.744 158.479 123.160 1.00 41.79  ? 1516 ARG A CG    1 
ATOM   6016 C  CD    . ARG A 1 1171 ? 146.676 159.789 122.407 1.00 36.64  ? 1516 ARG A CD    1 
ATOM   6017 N  NE    . ARG A 1 1171 ? 147.910 160.073 121.688 1.00 38.54  ? 1516 ARG A NE    1 
ATOM   6018 C  CZ    . ARG A 1 1171 ? 148.243 159.524 120.529 1.00 39.12  ? 1516 ARG A CZ    1 
ATOM   6019 N  NH1   . ARG A 1 1171 ? 147.461 158.645 119.932 1.00 42.44  ? 1516 ARG A NH1   1 
ATOM   6020 N  NH2   . ARG A 1 1171 ? 149.392 159.867 119.956 1.00 41.99  ? 1516 ARG A NH2   1 
ATOM   6021 N  N     . LEU A 1 1172 ? 147.697 157.965 127.527 1.00 36.92  ? 1517 LEU A N     1 
ATOM   6022 C  CA    . LEU A 1 1172 ? 147.834 158.592 128.831 1.00 44.50  ? 1517 LEU A CA    1 
ATOM   6023 C  C     . LEU A 1 1172 ? 147.570 160.088 128.718 1.00 51.85  ? 1517 LEU A C     1 
ATOM   6024 O  O     . LEU A 1 1172 ? 147.871 160.719 127.703 1.00 56.96  ? 1517 LEU A O     1 
ATOM   6025 C  CB    . LEU A 1 1172 ? 149.230 158.360 129.405 1.00 43.76  ? 1517 LEU A CB    1 
ATOM   6026 C  CG    . LEU A 1 1172 ? 149.824 156.958 129.338 1.00 36.84  ? 1517 LEU A CG    1 
ATOM   6027 C  CD1   . LEU A 1 1172 ? 151.265 156.998 129.794 1.00 40.87  ? 1517 LEU A CD1   1 
ATOM   6028 C  CD2   . LEU A 1 1172 ? 149.020 156.002 130.190 1.00 40.02  ? 1517 LEU A CD2   1 
ATOM   6029 N  N     . GLU A 1 1173 ? 146.993 160.654 129.767 1.00 46.95  ? 1518 GLU A N     1 
ATOM   6030 C  CA    . GLU A 1 1173 ? 146.785 162.089 129.834 1.00 52.18  ? 1518 GLU A CA    1 
ATOM   6031 C  C     . GLU A 1 1173 ? 147.858 162.722 130.707 1.00 51.86  ? 1518 GLU A C     1 
ATOM   6032 O  O     . GLU A 1 1173 ? 148.373 162.100 131.638 1.00 48.36  ? 1518 GLU A O     1 
ATOM   6033 C  CB    . GLU A 1 1173 ? 145.394 162.424 130.375 1.00 58.76  ? 1518 GLU A CB    1 
ATOM   6034 C  CG    . GLU A 1 1173 ? 144.933 161.534 131.508 1.00 63.00  ? 1518 GLU A CG    1 
ATOM   6035 C  CD    . GLU A 1 1173 ? 143.424 161.428 131.581 1.00 65.60  ? 1518 GLU A CD    1 
ATOM   6036 O  OE1   . GLU A 1 1173 ? 142.777 162.414 131.991 1.00 63.61  ? 1518 GLU A OE1   1 
ATOM   6037 O  OE2   . GLU A 1 1173 ? 142.887 160.356 131.233 1.00 65.36  ? 1518 GLU A OE2   1 
ATOM   6038 N  N     . TRP A 1 1174 ? 148.200 163.970 130.384 1.00 37.37  ? 1519 TRP A N     1 
ATOM   6039 C  CA    . TRP A 1 1174 ? 149.256 164.659 131.114 1.00 32.58  ? 1519 TRP A CA    1 
ATOM   6040 C  C     . TRP A 1 1174 ? 148.890 164.841 132.579 1.00 45.60  ? 1519 TRP A C     1 
ATOM   6041 O  O     . TRP A 1 1174 ? 149.745 164.712 133.462 1.00 53.75  ? 1519 TRP A O     1 
ATOM   6042 C  CB    . TRP A 1 1174 ? 149.541 166.011 130.470 1.00 32.90  ? 1519 TRP A CB    1 
ATOM   6043 C  CG    . TRP A 1 1174 ? 150.258 165.931 129.168 1.00 32.24  ? 1519 TRP A CG    1 
ATOM   6044 C  CD1   . TRP A 1 1174 ? 149.763 166.262 127.946 1.00 40.97  ? 1519 TRP A CD1   1 
ATOM   6045 C  CD2   . TRP A 1 1174 ? 151.610 165.513 128.955 1.00 32.15  ? 1519 TRP A CD2   1 
ATOM   6046 N  NE1   . TRP A 1 1174 ? 150.719 166.069 126.982 1.00 44.75  ? 1519 TRP A NE1   1 
ATOM   6047 C  CE2   . TRP A 1 1174 ? 151.863 165.609 127.578 1.00 38.44  ? 1519 TRP A CE2   1 
ATOM   6048 C  CE3   . TRP A 1 1174 ? 152.628 165.062 129.796 1.00 38.76  ? 1519 TRP A CE3   1 
ATOM   6049 C  CZ2   . TRP A 1 1174 ? 153.091 165.270 127.021 1.00 45.06  ? 1519 TRP A CZ2   1 
ATOM   6050 C  CZ3   . TRP A 1 1174 ? 153.845 164.726 129.242 1.00 39.59  ? 1519 TRP A CZ3   1 
ATOM   6051 C  CH2   . TRP A 1 1174 ? 154.066 164.831 127.868 1.00 44.66  ? 1519 TRP A CH2   1 
ATOM   6052 N  N     . ASP A 1 1175 ? 147.629 165.152 132.859 1.00 52.08  ? 1520 ASP A N     1 
ATOM   6053 C  CA    . ASP A 1 1175 ? 147.169 165.374 134.221 1.00 47.49  ? 1520 ASP A CA    1 
ATOM   6054 C  C     . ASP A 1 1175 ? 146.744 164.093 134.922 1.00 45.59  ? 1520 ASP A C     1 
ATOM   6055 O  O     . ASP A 1 1175 ? 146.359 164.144 136.093 1.00 48.88  ? 1520 ASP A O     1 
ATOM   6056 C  CB    . ASP A 1 1175 ? 146.008 166.372 134.227 1.00 53.77  ? 1520 ASP A CB    1 
ATOM   6057 C  CG    . ASP A 1 1175 ? 146.437 167.765 133.815 1.00 58.79  ? 1520 ASP A CG    1 
ATOM   6058 O  OD1   . ASP A 1 1175 ? 147.483 168.236 134.309 1.00 56.05  ? 1520 ASP A OD1   1 
ATOM   6059 O  OD2   . ASP A 1 1175 ? 145.728 168.392 133.002 1.00 57.86  ? 1520 ASP A OD2   1 
ATOM   6060 N  N     . GLY A 1 1176 ? 146.802 162.957 134.247 1.00 44.53  ? 1521 GLY A N     1 
ATOM   6061 C  CA    . GLY A 1 1176 ? 146.389 161.691 134.813 1.00 40.28  ? 1521 GLY A CA    1 
ATOM   6062 C  C     . GLY A 1 1176 ? 147.529 160.942 135.459 1.00 42.51  ? 1521 GLY A C     1 
ATOM   6063 O  O     . GLY A 1 1176 ? 148.469 161.533 135.996 1.00 54.24  ? 1521 GLY A O     1 
ATOM   6064 N  N     . PHE A 1 1177 ? 147.441 159.615 135.417 1.00 41.70  ? 1522 PHE A N     1 
ATOM   6065 C  CA    . PHE A 1 1177 ? 148.497 158.782 135.967 1.00 39.37  ? 1522 PHE A CA    1 
ATOM   6066 C  C     . PHE A 1 1177 ? 148.603 157.498 135.158 1.00 42.08  ? 1522 PHE A C     1 
ATOM   6067 O  O     . PHE A 1 1177 ? 147.671 157.100 134.457 1.00 44.37  ? 1522 PHE A O     1 
ATOM   6068 C  CB    . PHE A 1 1177 ? 148.264 158.469 137.452 1.00 37.78  ? 1522 PHE A CB    1 
ATOM   6069 C  CG    . PHE A 1 1177 ? 146.886 157.961 137.770 1.00 38.29  ? 1522 PHE A CG    1 
ATOM   6070 C  CD1   . PHE A 1 1177 ? 146.525 156.661 137.477 1.00 31.65  ? 1522 PHE A CD1   1 
ATOM   6071 C  CD2   . PHE A 1 1177 ? 145.964 158.778 138.393 1.00 52.76  ? 1522 PHE A CD2   1 
ATOM   6072 C  CE1   . PHE A 1 1177 ? 145.266 156.194 137.779 1.00 41.14  ? 1522 PHE A CE1   1 
ATOM   6073 C  CE2   . PHE A 1 1177 ? 144.704 158.315 138.696 1.00 48.71  ? 1522 PHE A CE2   1 
ATOM   6074 C  CZ    . PHE A 1 1177 ? 144.356 157.022 138.390 1.00 50.27  ? 1522 PHE A CZ    1 
ATOM   6075 N  N     . PHE A 1 1178 ? 149.766 156.862 135.261 1.00 43.51  ? 1523 PHE A N     1 
ATOM   6076 C  CA    . PHE A 1 1178 ? 149.969 155.563 134.642 1.00 41.19  ? 1523 PHE A CA    1 
ATOM   6077 C  C     . PHE A 1 1178 ? 149.029 154.533 135.251 1.00 42.41  ? 1523 PHE A C     1 
ATOM   6078 O  O     . PHE A 1 1178 ? 148.725 154.567 136.444 1.00 58.09  ? 1523 PHE A O     1 
ATOM   6079 C  CB    . PHE A 1 1178 ? 151.411 155.099 134.837 1.00 46.03  ? 1523 PHE A CB    1 
ATOM   6080 C  CG    . PHE A 1 1178 ? 152.377 155.656 133.838 1.00 47.30  ? 1523 PHE A CG    1 
ATOM   6081 C  CD1   . PHE A 1 1178 ? 152.861 156.941 133.968 1.00 34.44  ? 1523 PHE A CD1   1 
ATOM   6082 C  CD2   . PHE A 1 1178 ? 152.822 154.880 132.784 1.00 41.05  ? 1523 PHE A CD2   1 
ATOM   6083 C  CE1   . PHE A 1 1178 ? 153.759 157.447 133.058 1.00 31.87  ? 1523 PHE A CE1   1 
ATOM   6084 C  CE2   . PHE A 1 1178 ? 153.719 155.382 131.871 1.00 38.15  ? 1523 PHE A CE2   1 
ATOM   6085 C  CZ    . PHE A 1 1178 ? 154.187 156.666 132.008 1.00 34.00  ? 1523 PHE A CZ    1 
ATOM   6086 N  N     . SER A 1 1179 ? 148.562 153.609 134.420 1.00 39.63  ? 1524 SER A N     1 
ATOM   6087 C  CA    . SER A 1 1179 ? 147.893 152.434 134.947 1.00 47.25  ? 1524 SER A CA    1 
ATOM   6088 C  C     . SER A 1 1179 ? 148.944 151.421 135.390 1.00 52.80  ? 1524 SER A C     1 
ATOM   6089 O  O     . SER A 1 1179 ? 150.149 151.638 135.242 1.00 57.07  ? 1524 SER A O     1 
ATOM   6090 C  CB    . SER A 1 1179 ? 146.941 151.848 133.911 1.00 47.84  ? 1524 SER A CB    1 
ATOM   6091 O  OG    . SER A 1 1179 ? 145.789 152.658 133.768 1.00 52.99  ? 1524 SER A OG    1 
ATOM   6092 N  N     . THR A 1 1180 ? 148.490 150.301 135.950 1.00 57.63  ? 1525 THR A N     1 
ATOM   6093 C  CA    . THR A 1 1180 ? 149.410 149.300 136.478 1.00 54.62  ? 1525 THR A CA    1 
ATOM   6094 C  C     . THR A 1 1180 ? 150.350 148.792 135.395 1.00 54.48  ? 1525 THR A C     1 
ATOM   6095 O  O     . THR A 1 1180 ? 149.914 148.137 134.444 1.00 57.00  ? 1525 THR A O     1 
ATOM   6096 C  CB    . THR A 1 1180 ? 148.640 148.134 137.094 1.00 57.28  ? 1525 THR A CB    1 
ATOM   6097 O  OG1   . THR A 1 1180 ? 147.730 148.631 138.082 1.00 57.97  ? 1525 THR A OG1   1 
ATOM   6098 C  CG2   . THR A 1 1180 ? 149.598 147.159 137.745 1.00 54.07  ? 1525 THR A CG2   1 
ATOM   6099 N  N     . THR A 1 1181 ? 151.638 149.096 135.530 1.00 56.04  ? 1526 THR A N     1 
ATOM   6100 C  CA    . THR A 1 1181 ? 152.618 148.692 134.532 1.00 58.39  ? 1526 THR A CA    1 
ATOM   6101 C  C     . THR A 1 1181 ? 152.742 147.175 134.481 1.00 56.96  ? 1526 THR A C     1 
ATOM   6102 O  O     . THR A 1 1181 ? 152.833 146.506 135.513 1.00 57.02  ? 1526 THR A O     1 
ATOM   6103 C  CB    . THR A 1 1181 ? 153.980 149.314 134.839 1.00 54.36  ? 1526 THR A CB    1 
ATOM   6104 O  OG1   . THR A 1 1181 ? 153.874 150.741 134.814 1.00 55.40  ? 1526 THR A OG1   1 
ATOM   6105 C  CG2   . THR A 1 1181 ? 155.010 148.877 133.818 1.00 54.42  ? 1526 THR A CG2   1 
ATOM   6106 N  N     . VAL A 1 1182 ? 152.748 146.633 133.268 1.00 51.81  ? 1527 VAL A N     1 
ATOM   6107 C  CA    . VAL A 1 1182 ? 152.926 145.208 133.055 1.00 55.98  ? 1527 VAL A CA    1 
ATOM   6108 C  C     . VAL A 1 1182 ? 154.279 144.985 132.389 1.00 57.94  ? 1527 VAL A C     1 
ATOM   6109 O  O     . VAL A 1 1182 ? 154.989 145.926 132.036 1.00 60.59  ? 1527 VAL A O     1 
ATOM   6110 C  CB    . VAL A 1 1182 ? 151.783 144.597 132.223 1.00 54.75  ? 1527 VAL A CB    1 
ATOM   6111 C  CG1   . VAL A 1 1182 ? 150.463 144.757 132.953 1.00 54.18  ? 1527 VAL A CG1   1 
ATOM   6112 C  CG2   . VAL A 1 1182 ? 151.723 145.239 130.850 1.00 54.61  ? 1527 VAL A CG2   1 
ATOM   6113 N  N     . THR A 1 1183 ? 154.638 143.710 132.228 1.00 53.95  ? 1528 THR A N     1 
ATOM   6114 C  CA    . THR A 1 1183 ? 155.954 143.374 131.697 1.00 59.50  ? 1528 THR A CA    1 
ATOM   6115 C  C     . THR A 1 1183 ? 156.119 143.849 130.260 1.00 64.15  ? 1528 THR A C     1 
ATOM   6116 O  O     . THR A 1 1183 ? 157.164 144.401 129.898 1.00 64.58  ? 1528 THR A O     1 
ATOM   6117 C  CB    . THR A 1 1183 ? 156.182 141.868 131.790 1.00 61.47  ? 1528 THR A CB    1 
ATOM   6118 O  OG1   . THR A 1 1183 ? 155.082 141.181 131.181 1.00 64.56  ? 1528 THR A OG1   1 
ATOM   6119 C  CG2   . THR A 1 1183 ? 156.289 141.443 133.239 1.00 59.08  ? 1528 THR A CG2   1 
ATOM   6120 N  N     . ASN A 1 1184 ? 155.102 143.647 129.427 1.00 60.34  ? 1529 ASN A N     1 
ATOM   6121 C  CA    . ASN A 1 1184 ? 155.170 143.989 128.005 1.00 58.83  ? 1529 ASN A CA    1 
ATOM   6122 C  C     . ASN A 1 1184 ? 154.170 145.089 127.688 1.00 64.04  ? 1529 ASN A C     1 
ATOM   6123 O  O     . ASN A 1 1184 ? 152.960 144.820 127.587 1.00 75.03  ? 1529 ASN A O     1 
ATOM   6124 C  CB    . ASN A 1 1184 ? 154.902 142.757 127.144 1.00 62.24  ? 1529 ASN A CB    1 
ATOM   6125 C  CG    . ASN A 1 1184 ? 155.442 142.901 125.741 1.00 65.08  ? 1529 ASN A CG    1 
ATOM   6126 O  OD1   . ASN A 1 1184 ? 156.183 143.835 125.443 1.00 67.92  ? 1529 ASN A OD1   1 
ATOM   6127 N  ND2   . ASN A 1 1184 ? 155.077 141.972 124.869 1.00 60.69  ? 1529 ASN A ND2   1 
ATOM   6128 N  N     . PRO A 1 1185 ? 154.613 146.333 127.523 1.00 56.06  ? 1530 PRO A N     1 
ATOM   6129 C  CA    . PRO A 1 1185 ? 153.672 147.416 127.210 1.00 59.27  ? 1530 PRO A CA    1 
ATOM   6130 C  C     . PRO A 1 1185 ? 153.177 147.372 125.774 1.00 61.01  ? 1530 PRO A C     1 
ATOM   6131 O  O     . PRO A 1 1185 ? 153.678 148.105 124.917 1.00 58.59  ? 1530 PRO A O     1 
ATOM   6132 C  CB    . PRO A 1 1185 ? 154.497 148.678 127.477 1.00 51.96  ? 1530 PRO A CB    1 
ATOM   6133 C  CG    . PRO A 1 1185 ? 155.891 148.256 127.229 1.00 56.60  ? 1530 PRO A CG    1 
ATOM   6134 C  CD    . PRO A 1 1185 ? 155.987 146.830 127.690 1.00 55.47  ? 1530 PRO A CD    1 
ATOM   6135 N  N     . GLU A 1 1186 ? 152.196 146.516 125.501 1.00 70.67  ? 1531 GLU A N     1 
ATOM   6136 C  CA    . GLU A 1 1186 ? 151.591 146.435 124.185 1.00 65.60  ? 1531 GLU A CA    1 
ATOM   6137 C  C     . GLU A 1 1186 ? 150.190 147.031 124.212 1.00 69.44  ? 1531 GLU A C     1 
ATOM   6138 O  O     . GLU A 1 1186 ? 149.472 146.872 125.204 1.00 74.48  ? 1531 GLU A O     1 
ATOM   6139 C  CB    . GLU A 1 1186 ? 151.512 144.983 123.702 1.00 64.67  ? 1531 GLU A CB    1 
ATOM   6140 C  CG    . GLU A 1 1186 ? 151.381 143.972 124.824 1.00 69.11  ? 1531 GLU A CG    1 
ATOM   6141 C  CD    . GLU A 1 1186 ? 151.014 142.593 124.321 1.00 73.05  ? 1531 GLU A CD    1 
ATOM   6142 O  OE1   . GLU A 1 1186 ? 151.420 142.247 123.192 1.00 78.82  ? 1531 GLU A OE1   1 
ATOM   6143 O  OE2   . GLU A 1 1186 ? 150.323 141.854 125.054 1.00 68.62  ? 1531 GLU A OE2   1 
ATOM   6144 N  N     . PRO A 1 1187 ? 149.778 147.728 123.151 1.00 58.79  ? 1532 PRO A N     1 
ATOM   6145 C  CA    . PRO A 1 1187 ? 148.451 148.360 123.167 1.00 54.88  ? 1532 PRO A CA    1 
ATOM   6146 C  C     . PRO A 1 1187 ? 147.302 147.373 123.267 1.00 54.12  ? 1532 PRO A C     1 
ATOM   6147 O  O     . PRO A 1 1187 ? 146.276 147.696 123.875 1.00 62.49  ? 1532 PRO A O     1 
ATOM   6148 C  CB    . PRO A 1 1187 ? 148.423 149.133 121.843 1.00 54.75  ? 1532 PRO A CB    1 
ATOM   6149 C  CG    . PRO A 1 1187 ? 149.359 148.396 120.966 1.00 58.82  ? 1532 PRO A CG    1 
ATOM   6150 C  CD    . PRO A 1 1187 ? 150.459 147.915 121.860 1.00 57.35  ? 1532 PRO A CD    1 
ATOM   6151 N  N     . MET A 1 1188 ? 147.440 146.180 122.699 1.00 46.10  ? 1533 MET A N     1 
ATOM   6152 C  CA    . MET A 1 1188 ? 146.346 145.220 122.650 1.00 47.49  ? 1533 MET A CA    1 
ATOM   6153 C  C     . MET A 1 1188 ? 146.299 144.295 123.859 1.00 55.79  ? 1533 MET A C     1 
ATOM   6154 O  O     . MET A 1 1188 ? 145.445 143.406 123.904 1.00 61.81  ? 1533 MET A O     1 
ATOM   6155 C  CB    . MET A 1 1188 ? 146.437 144.386 121.370 1.00 54.72  ? 1533 MET A CB    1 
ATOM   6156 C  CG    . MET A 1 1188 ? 145.884 145.084 120.142 1.00 52.38  ? 1533 MET A CG    1 
ATOM   6157 S  SD    . MET A 1 1188 ? 144.264 144.468 119.667 1.00 58.11  ? 1533 MET A SD    1 
ATOM   6158 C  CE    . MET A 1 1188 ? 144.671 142.777 119.253 1.00 50.95  ? 1533 MET A CE    1 
ATOM   6159 N  N     . GLY A 1 1189 ? 147.187 144.473 124.830 1.00 60.62  ? 1534 GLY A N     1 
ATOM   6160 C  CA    . GLY A 1 1189 ? 147.106 143.702 126.051 1.00 62.11  ? 1534 GLY A CA    1 
ATOM   6161 C  C     . GLY A 1 1189 ? 145.944 144.154 126.908 1.00 61.59  ? 1534 GLY A C     1 
ATOM   6162 O  O     . GLY A 1 1189 ? 145.292 145.159 126.639 1.00 68.01  ? 1534 GLY A O     1 
ATOM   6163 N  N     . LYS A 1 1190 ? 145.672 143.387 127.967 1.00 67.14  ? 1535 LYS A N     1 
ATOM   6164 C  CA    . LYS A 1 1190 ? 144.563 143.739 128.848 1.00 69.53  ? 1535 LYS A CA    1 
ATOM   6165 C  C     . LYS A 1 1190 ? 144.780 145.109 129.474 1.00 67.78  ? 1535 LYS A C     1 
ATOM   6166 O  O     . LYS A 1 1190 ? 143.850 145.919 129.553 1.00 69.97  ? 1535 LYS A O     1 
ATOM   6167 C  CB    . LYS A 1 1190 ? 144.374 142.671 129.921 1.00 68.80  ? 1535 LYS A CB    1 
ATOM   6168 C  CG    . LYS A 1 1190 ? 143.094 141.879 129.748 1.00 69.97  ? 1535 LYS A CG    1 
ATOM   6169 C  CD    . LYS A 1 1190 ? 143.155 140.544 130.454 1.00 70.05  ? 1535 LYS A CD    1 
ATOM   6170 C  CE    . LYS A 1 1190 ? 141.990 139.669 130.041 1.00 67.30  ? 1535 LYS A CE    1 
ATOM   6171 N  NZ    . LYS A 1 1190 ? 140.713 140.433 130.043 1.00 74.58  ? 1535 LYS A NZ    1 
ATOM   6172 N  N     . GLN A 1 1191 ? 146.000 145.390 129.917 1.00 53.93  ? 1536 GLN A N     1 
ATOM   6173 C  CA    . GLN A 1 1191 ? 146.414 146.752 130.226 1.00 49.31  ? 1536 GLN A CA    1 
ATOM   6174 C  C     . GLN A 1 1191 ? 146.926 147.362 128.927 1.00 60.97  ? 1536 GLN A C     1 
ATOM   6175 O  O     . GLN A 1 1191 ? 147.971 146.955 128.409 1.00 71.25  ? 1536 GLN A O     1 
ATOM   6176 C  CB    . GLN A 1 1191 ? 147.472 146.763 131.326 1.00 49.57  ? 1536 GLN A CB    1 
ATOM   6177 C  CG    . GLN A 1 1191 ? 148.489 147.887 131.234 1.00 57.99  ? 1536 GLN A CG    1 
ATOM   6178 C  CD    . GLN A 1 1191 ? 147.950 149.214 131.712 1.00 59.15  ? 1536 GLN A CD    1 
ATOM   6179 O  OE1   . GLN A 1 1191 ? 146.755 149.359 131.961 1.00 61.11  ? 1536 GLN A OE1   1 
ATOM   6180 N  NE2   . GLN A 1 1191 ? 148.833 150.195 131.844 1.00 58.31  ? 1536 GLN A NE2   1 
ATOM   6181 N  N     . GLY A 1 1192 ? 146.171 148.308 128.376 1.00 52.63  ? 1537 GLY A N     1 
ATOM   6182 C  CA    . GLY A 1 1192 ? 146.470 148.804 127.048 1.00 50.56  ? 1537 GLY A CA    1 
ATOM   6183 C  C     . GLY A 1 1192 ? 146.744 150.289 126.962 1.00 56.54  ? 1537 GLY A C     1 
ATOM   6184 O  O     . GLY A 1 1192 ? 147.174 150.781 125.917 1.00 65.14  ? 1537 GLY A O     1 
ATOM   6185 N  N     . ARG A 1 1193 ? 146.509 151.020 128.049 1.00 48.63  ? 1538 ARG A N     1 
ATOM   6186 C  CA    . ARG A 1 1193 ? 146.726 152.465 128.061 1.00 45.00  ? 1538 ARG A CA    1 
ATOM   6187 C  C     . ARG A 1 1193 ? 148.230 152.717 128.083 1.00 49.66  ? 1538 ARG A C     1 
ATOM   6188 O  O     . ARG A 1 1193 ? 148.846 152.945 129.126 1.00 44.92  ? 1538 ARG A O     1 
ATOM   6189 C  CB    . ARG A 1 1193 ? 146.028 153.100 129.255 1.00 43.79  ? 1538 ARG A CB    1 
ATOM   6190 C  CG    . ARG A 1 1193 ? 144.625 153.591 128.964 1.00 50.11  ? 1538 ARG A CG    1 
ATOM   6191 C  CD    . ARG A 1 1193 ? 144.035 154.293 130.171 1.00 54.09  ? 1538 ARG A CD    1 
ATOM   6192 N  NE    . ARG A 1 1193 ? 144.798 155.479 130.537 1.00 56.55  ? 1538 ARG A NE    1 
ATOM   6193 C  CZ    . ARG A 1 1193 ? 145.501 155.602 131.654 1.00 56.70  ? 1538 ARG A CZ    1 
ATOM   6194 N  NH1   . ARG A 1 1193 ? 145.551 154.631 132.549 1.00 54.00  ? 1538 ARG A NH1   1 
ATOM   6195 N  NH2   . ARG A 1 1193 ? 146.168 156.730 131.881 1.00 58.81  ? 1538 ARG A NH2   1 
ATOM   6196 N  N     . VAL A 1 1194 ? 148.832 152.671 126.897 1.00 42.92  ? 1539 VAL A N     1 
ATOM   6197 C  CA    . VAL A 1 1194 ? 150.285 152.755 126.779 1.00 36.65  ? 1539 VAL A CA    1 
ATOM   6198 C  C     . VAL A 1 1194 ? 150.762 153.839 125.829 1.00 44.14  ? 1539 VAL A C     1 
ATOM   6199 O  O     . VAL A 1 1194 ? 151.937 154.235 125.905 1.00 51.88  ? 1539 VAL A O     1 
ATOM   6200 C  CB    . VAL A 1 1194 ? 150.867 151.391 126.356 1.00 48.49  ? 1539 VAL A CB    1 
ATOM   6201 C  CG1   . VAL A 1 1194 ? 150.555 150.333 127.397 1.00 47.61  ? 1539 VAL A CG1   1 
ATOM   6202 C  CG2   . VAL A 1 1194 ? 150.324 150.991 124.999 1.00 49.00  ? 1539 VAL A CG2   1 
ATOM   6203 N  N     . LEU A 1 1195 ? 149.940 154.352 124.917 1.00 38.38  ? 1540 LEU A N     1 
ATOM   6204 C  CA    . LEU A 1 1195 ? 150.425 155.339 123.963 1.00 32.43  ? 1540 LEU A CA    1 
ATOM   6205 C  C     . LEU A 1 1195 ? 150.822 156.629 124.669 1.00 35.87  ? 1540 LEU A C     1 
ATOM   6206 O  O     . LEU A 1 1195 ? 150.315 156.963 125.740 1.00 39.09  ? 1540 LEU A O     1 
ATOM   6207 C  CB    . LEU A 1 1195 ? 149.371 155.647 122.902 1.00 34.34  ? 1540 LEU A CB    1 
ATOM   6208 C  CG    . LEU A 1 1195 ? 148.592 154.519 122.233 1.00 35.84  ? 1540 LEU A CG    1 
ATOM   6209 C  CD1   . LEU A 1 1195 ? 147.774 155.087 121.095 1.00 34.91  ? 1540 LEU A CD1   1 
ATOM   6210 C  CD2   . LEU A 1 1195 ? 149.518 153.435 121.734 1.00 44.37  ? 1540 LEU A CD2   1 
ATOM   6211 N  N     . HIS A 1 1196 ? 151.750 157.351 124.053 1.00 37.52  ? 1541 HIS A N     1 
ATOM   6212 C  CA    . HIS A 1 1196 ? 152.190 158.623 124.591 1.00 37.41  ? 1541 HIS A CA    1 
ATOM   6213 C  C     . HIS A 1 1196 ? 151.060 159.649 124.517 1.00 46.58  ? 1541 HIS A C     1 
ATOM   6214 O  O     . HIS A 1 1196 ? 150.208 159.580 123.627 1.00 51.27  ? 1541 HIS A O     1 
ATOM   6215 C  CB    . HIS A 1 1196 ? 153.401 159.126 123.817 1.00 46.62  ? 1541 HIS A CB    1 
ATOM   6216 C  CG    . HIS A 1 1196 ? 154.281 160.048 124.597 1.00 50.58  ? 1541 HIS A CG    1 
ATOM   6217 N  ND1   . HIS A 1 1196 ? 154.268 161.414 124.422 1.00 46.85  ? 1541 HIS A ND1   1 
ATOM   6218 C  CD2   . HIS A 1 1196 ? 155.205 159.800 125.554 1.00 51.99  ? 1541 HIS A CD2   1 
ATOM   6219 C  CE1   . HIS A 1 1196 ? 155.144 161.969 125.238 1.00 46.90  ? 1541 HIS A CE1   1 
ATOM   6220 N  NE2   . HIS A 1 1196 ? 155.727 161.012 125.936 1.00 56.52  ? 1541 HIS A NE2   1 
ATOM   6221 N  N     . PRO A 1 1197 ? 151.020 160.602 125.451 1.00 46.69  ? 1542 PRO A N     1 
ATOM   6222 C  CA    . PRO A 1 1197 ? 149.970 161.632 125.390 1.00 38.29  ? 1542 PRO A CA    1 
ATOM   6223 C  C     . PRO A 1 1197 ? 149.962 162.420 124.094 1.00 49.98  ? 1542 PRO A C     1 
ATOM   6224 O  O     . PRO A 1 1197 ? 148.886 162.798 123.617 1.00 60.44  ? 1542 PRO A O     1 
ATOM   6225 C  CB    . PRO A 1 1197 ? 150.295 162.525 126.592 1.00 39.02  ? 1542 PRO A CB    1 
ATOM   6226 C  CG    . PRO A 1 1197 ? 151.021 161.648 127.532 1.00 40.91  ? 1542 PRO A CG    1 
ATOM   6227 C  CD    . PRO A 1 1197 ? 151.791 160.673 126.702 1.00 48.14  ? 1542 PRO A CD    1 
ATOM   6228 N  N     . GLU A 1 1198 ? 151.129 162.688 123.510 1.00 50.03  ? 1543 GLU A N     1 
ATOM   6229 C  CA    . GLU A 1 1198 ? 151.209 163.462 122.276 1.00 49.66  ? 1543 GLU A CA    1 
ATOM   6230 C  C     . GLU A 1 1198 ? 151.744 162.640 121.112 1.00 57.44  ? 1543 GLU A C     1 
ATOM   6231 O  O     . GLU A 1 1198 ? 151.073 162.535 120.081 1.00 68.15  ? 1543 GLU A O     1 
ATOM   6232 C  CB    . GLU A 1 1198 ? 152.081 164.704 122.492 1.00 49.20  ? 1543 GLU A CB    1 
ATOM   6233 C  CG    . GLU A 1 1198 ? 151.608 165.609 123.606 1.00 53.73  ? 1543 GLU A CG    1 
ATOM   6234 C  CD    . GLU A 1 1198 ? 152.645 166.644 123.980 1.00 59.58  ? 1543 GLU A CD    1 
ATOM   6235 O  OE1   . GLU A 1 1198 ? 153.767 166.582 123.437 1.00 64.52  ? 1543 GLU A OE1   1 
ATOM   6236 O  OE2   . GLU A 1 1198 ? 152.341 167.519 124.817 1.00 57.43  ? 1543 GLU A OE2   1 
ATOM   6237 N  N     . GLN A 1 1199 ? 152.929 162.052 121.242 1.00 50.15  ? 1544 GLN A N     1 
ATOM   6238 C  CA    . GLN A 1 1199 ? 153.547 161.357 120.123 1.00 45.98  ? 1544 GLN A CA    1 
ATOM   6239 C  C     . GLN A 1 1199 ? 152.848 160.032 119.852 1.00 48.20  ? 1544 GLN A C     1 
ATOM   6240 O  O     . GLN A 1 1199 ? 152.294 159.398 120.753 1.00 48.25  ? 1544 GLN A O     1 
ATOM   6241 C  CB    . GLN A 1 1199 ? 155.028 161.120 120.400 1.00 47.31  ? 1544 GLN A CB    1 
ATOM   6242 C  CG    . GLN A 1 1199 ? 155.772 162.372 120.811 1.00 51.41  ? 1544 GLN A CG    1 
ATOM   6243 C  CD    . GLN A 1 1199 ? 156.964 162.074 121.690 1.00 50.20  ? 1544 GLN A CD    1 
ATOM   6244 O  OE1   . GLN A 1 1199 ? 157.484 160.960 121.693 1.00 46.57  ? 1544 GLN A OE1   1 
ATOM   6245 N  NE2   . GLN A 1 1199 ? 157.404 163.072 122.445 1.00 48.46  ? 1544 GLN A NE2   1 
ATOM   6246 N  N     . HIS A 1 1200 ? 152.882 159.614 118.588 1.00 48.06  ? 1545 HIS A N     1 
ATOM   6247 C  CA    . HIS A 1 1200 ? 152.235 158.373 118.160 1.00 50.20  ? 1545 HIS A CA    1 
ATOM   6248 C  C     . HIS A 1 1200 ? 153.199 157.203 118.347 1.00 48.52  ? 1545 HIS A C     1 
ATOM   6249 O  O     . HIS A 1 1200 ? 153.751 156.641 117.400 1.00 54.27  ? 1545 HIS A O     1 
ATOM   6250 C  CB    . HIS A 1 1200 ? 151.769 158.493 116.716 1.00 52.70  ? 1545 HIS A CB    1 
ATOM   6251 C  CG    . HIS A 1 1200 ? 151.144 159.813 116.393 1.00 54.88  ? 1545 HIS A CG    1 
ATOM   6252 N  ND1   . HIS A 1 1200 ? 149.934 160.211 116.918 1.00 56.03  ? 1545 HIS A ND1   1 
ATOM   6253 C  CD2   . HIS A 1 1200 ? 151.566 160.830 115.605 1.00 55.93  ? 1545 HIS A CD2   1 
ATOM   6254 C  CE1   . HIS A 1 1200 ? 149.635 161.415 116.464 1.00 57.64  ? 1545 HIS A CE1   1 
ATOM   6255 N  NE2   . HIS A 1 1200 ? 150.609 161.813 115.666 1.00 57.43  ? 1545 HIS A NE2   1 
ATOM   6256 N  N     . ARG A 1 1201 ? 153.395 156.840 119.611 1.00 35.94  ? 1546 ARG A N     1 
ATOM   6257 C  CA    . ARG A 1 1201 ? 154.317 155.767 119.949 1.00 36.43  ? 1546 ARG A CA    1 
ATOM   6258 C  C     . ARG A 1 1201 ? 153.950 155.200 121.310 1.00 41.53  ? 1546 ARG A C     1 
ATOM   6259 O  O     . ARG A 1 1201 ? 153.192 155.805 122.072 1.00 46.51  ? 1546 ARG A O     1 
ATOM   6260 C  CB    . ARG A 1 1201 ? 155.767 156.254 119.945 1.00 42.88  ? 1546 ARG A CB    1 
ATOM   6261 C  CG    . ARG A 1 1201 ? 156.047 157.344 120.955 1.00 42.41  ? 1546 ARG A CG    1 
ATOM   6262 C  CD    . ARG A 1 1201 ? 157.529 157.481 121.195 1.00 42.40  ? 1546 ARG A CD    1 
ATOM   6263 N  NE    . ARG A 1 1201 ? 157.823 158.458 122.232 1.00 40.63  ? 1546 ARG A NE    1 
ATOM   6264 C  CZ    . ARG A 1 1201 ? 157.920 158.166 123.520 1.00 41.75  ? 1546 ARG A CZ    1 
ATOM   6265 N  NH1   . ARG A 1 1201 ? 157.734 156.934 123.963 1.00 44.15  ? 1546 ARG A NH1   1 
ATOM   6266 N  NH2   . ARG A 1 1201 ? 158.213 159.132 124.386 1.00 38.84  ? 1546 ARG A NH2   1 
ATOM   6267 N  N     . VAL A 1 1202 ? 154.500 154.024 121.599 1.00 41.07  ? 1547 VAL A N     1 
ATOM   6268 C  CA    . VAL A 1 1202 ? 154.317 153.401 122.902 1.00 33.11  ? 1547 VAL A CA    1 
ATOM   6269 C  C     . VAL A 1 1202 ? 155.279 154.028 123.908 1.00 45.45  ? 1547 VAL A C     1 
ATOM   6270 O  O     . VAL A 1 1202 ? 156.280 154.651 123.547 1.00 55.94  ? 1547 VAL A O     1 
ATOM   6271 C  CB    . VAL A 1 1202 ? 154.518 151.880 122.806 1.00 34.07  ? 1547 VAL A CB    1 
ATOM   6272 C  CG1   . VAL A 1 1202 ? 153.834 151.173 123.953 1.00 38.44  ? 1547 VAL A CG1   1 
ATOM   6273 C  CG2   . VAL A 1 1202 ? 153.991 151.369 121.482 1.00 40.57  ? 1547 VAL A CG2   1 
ATOM   6274 N  N     . VAL A 1 1203 ? 154.960 153.871 125.194 1.00 41.69  ? 1548 VAL A N     1 
ATOM   6275 C  CA    . VAL A 1 1203 ? 155.812 154.415 126.244 1.00 32.43  ? 1548 VAL A CA    1 
ATOM   6276 C  C     . VAL A 1 1203 ? 157.158 153.710 126.224 1.00 38.33  ? 1548 VAL A C     1 
ATOM   6277 O  O     . VAL A 1 1203 ? 157.235 152.479 126.128 1.00 54.49  ? 1548 VAL A O     1 
ATOM   6278 C  CB    . VAL A 1 1203 ? 155.128 154.283 127.611 1.00 36.73  ? 1548 VAL A CB    1 
ATOM   6279 C  CG1   . VAL A 1 1203 ? 154.149 155.418 127.818 1.00 40.44  ? 1548 VAL A CG1   1 
ATOM   6280 C  CG2   . VAL A 1 1203 ? 154.425 152.949 127.720 1.00 33.89  ? 1548 VAL A CG2   1 
ATOM   6281 N  N     . SER A 1 1204 ? 158.230 154.490 126.317 1.00 25.82  ? 1549 SER A N     1 
ATOM   6282 C  CA    . SER A 1 1204 ? 159.574 153.948 126.216 1.00 31.96  ? 1549 SER A CA    1 
ATOM   6283 C  C     . SER A 1 1204 ? 159.941 153.168 127.477 1.00 42.85  ? 1549 SER A C     1 
ATOM   6284 O  O     . SER A 1 1204 ? 159.193 153.118 128.456 1.00 53.25  ? 1549 SER A O     1 
ATOM   6285 C  CB    . SER A 1 1204 ? 160.580 155.070 125.979 1.00 34.31  ? 1549 SER A CB    1 
ATOM   6286 O  OG    . SER A 1 1204 ? 161.868 154.701 126.432 1.00 43.98  ? 1549 SER A OG    1 
ATOM   6287 N  N     . VAL A 1 1205 ? 161.116 152.537 127.435 1.00 41.75  ? 1550 VAL A N     1 
ATOM   6288 C  CA    . VAL A 1 1205 ? 161.619 151.828 128.607 1.00 31.98  ? 1550 VAL A CA    1 
ATOM   6289 C  C     . VAL A 1 1205 ? 161.912 152.807 129.734 1.00 31.13  ? 1550 VAL A C     1 
ATOM   6290 O  O     . VAL A 1 1205 ? 161.594 152.544 130.899 1.00 45.43  ? 1550 VAL A O     1 
ATOM   6291 C  CB    . VAL A 1 1205 ? 162.861 150.996 128.244 1.00 35.38  ? 1550 VAL A CB    1 
ATOM   6292 C  CG1   . VAL A 1 1205 ? 163.447 150.358 129.484 1.00 33.63  ? 1550 VAL A CG1   1 
ATOM   6293 C  CG2   . VAL A 1 1205 ? 162.505 149.936 127.223 1.00 39.27  ? 1550 VAL A CG2   1 
ATOM   6294 N  N     . ARG A 1 1206 ? 162.523 153.948 129.412 1.00 18.53  ? 1551 ARG A N     1 
ATOM   6295 C  CA    . ARG A 1 1206 ? 162.810 154.939 130.442 1.00 18.51  ? 1551 ARG A CA    1 
ATOM   6296 C  C     . ARG A 1 1206 ? 161.528 155.532 131.010 1.00 35.89  ? 1551 ARG A C     1 
ATOM   6297 O  O     . ARG A 1 1206 ? 161.445 155.806 132.212 1.00 60.15  ? 1551 ARG A O     1 
ATOM   6298 C  CB    . ARG A 1 1206 ? 163.713 156.036 129.884 1.00 19.93  ? 1551 ARG A CB    1 
ATOM   6299 C  CG    . ARG A 1 1206 ? 164.163 157.050 130.917 1.00 26.43  ? 1551 ARG A CG    1 
ATOM   6300 C  CD    . ARG A 1 1206 ? 164.654 156.380 132.188 1.00 29.76  ? 1551 ARG A CD    1 
ATOM   6301 N  NE    . ARG A 1 1206 ? 165.935 155.714 132.001 1.00 36.62  ? 1551 ARG A NE    1 
ATOM   6302 C  CZ    . ARG A 1 1206 ? 166.332 154.649 132.684 1.00 43.77  ? 1551 ARG A CZ    1 
ATOM   6303 N  NH1   . ARG A 1 1206 ? 165.569 154.101 133.614 1.00 28.79  ? 1551 ARG A NH1   1 
ATOM   6304 N  NH2   . ARG A 1 1206 ? 167.524 154.121 132.427 1.00 38.89  ? 1551 ARG A NH2   1 
ATOM   6305 N  N     . GLU A 1 1207 ? 160.513 155.731 130.167 1.00 33.26  ? 1552 GLU A N     1 
ATOM   6306 C  CA    . GLU A 1 1207 ? 159.232 156.219 130.665 1.00 21.03  ? 1552 GLU A CA    1 
ATOM   6307 C  C     . GLU A 1 1207 ? 158.599 155.222 131.625 1.00 23.04  ? 1552 GLU A C     1 
ATOM   6308 O  O     . GLU A 1 1207 ? 158.048 155.611 132.659 1.00 38.87  ? 1552 GLU A O     1 
ATOM   6309 C  CB    . GLU A 1 1207 ? 158.294 156.517 129.498 1.00 35.53  ? 1552 GLU A CB    1 
ATOM   6310 C  CG    . GLU A 1 1207 ? 158.595 157.827 128.795 1.00 41.86  ? 1552 GLU A CG    1 
ATOM   6311 C  CD    . GLU A 1 1207 ? 158.465 157.737 127.289 1.00 52.98  ? 1552 GLU A CD    1 
ATOM   6312 O  OE1   . GLU A 1 1207 ? 157.944 156.719 126.796 1.00 49.79  ? 1552 GLU A OE1   1 
ATOM   6313 O  OE2   . GLU A 1 1207 ? 158.885 158.685 126.594 1.00 45.59  ? 1552 GLU A OE2   1 
ATOM   6314 N  N     . CYS A 1 1208 ? 158.675 153.928 131.308 1.00 24.25  ? 1553 CYS A N     1 
ATOM   6315 C  CA    . CYS A 1 1208 ? 158.151 152.914 132.220 1.00 29.27  ? 1553 CYS A CA    1 
ATOM   6316 C  C     . CYS A 1 1208 ? 158.936 152.881 133.528 1.00 28.44  ? 1553 CYS A C     1 
ATOM   6317 O  O     . CYS A 1 1208 ? 158.347 152.791 134.614 1.00 25.92  ? 1553 CYS A O     1 
ATOM   6318 C  CB    . CYS A 1 1208 ? 158.175 151.545 131.543 1.00 31.95  ? 1553 CYS A CB    1 
ATOM   6319 S  SG    . CYS A 1 1208 ? 156.926 151.324 130.264 1.00 53.42  ? 1553 CYS A SG    1 
ATOM   6320 N  N     . ALA A 1 1209 ? 160.265 152.959 133.444 1.00 19.57  ? 1554 ALA A N     1 
ATOM   6321 C  CA    . ALA A 1 1209 ? 161.085 152.942 134.649 1.00 14.62  ? 1554 ALA A CA    1 
ATOM   6322 C  C     . ALA A 1 1209 ? 160.831 154.164 135.515 1.00 35.69  ? 1554 ALA A C     1 
ATOM   6323 O  O     . ALA A 1 1209 ? 160.948 154.087 136.742 1.00 48.47  ? 1554 ALA A O     1 
ATOM   6324 C  CB    . ALA A 1 1209 ? 162.563 152.855 134.281 1.00 21.22  ? 1554 ALA A CB    1 
ATOM   6325 N  N     . ARG A 1 1210 ? 160.497 155.301 134.905 1.00 26.35  ? 1555 ARG A N     1 
ATOM   6326 C  CA    . ARG A 1 1210 ? 160.113 156.463 135.698 1.00 20.91  ? 1555 ARG A CA    1 
ATOM   6327 C  C     . ARG A 1 1210 ? 158.706 156.314 136.258 1.00 23.92  ? 1555 ARG A C     1 
ATOM   6328 O  O     . ARG A 1 1210 ? 158.414 156.835 137.339 1.00 37.63  ? 1555 ARG A O     1 
ATOM   6329 C  CB    . ARG A 1 1210 ? 160.232 157.731 134.862 1.00 21.41  ? 1555 ARG A CB    1 
ATOM   6330 C  CG    . ARG A 1 1210 ? 161.651 158.229 134.753 1.00 25.05  ? 1555 ARG A CG    1 
ATOM   6331 C  CD    . ARG A 1 1210 ? 161.703 159.641 134.241 1.00 19.90  ? 1555 ARG A CD    1 
ATOM   6332 N  NE    . ARG A 1 1210 ? 163.070 160.137 134.209 1.00 24.27  ? 1555 ARG A NE    1 
ATOM   6333 C  CZ    . ARG A 1 1210 ? 163.447 161.241 133.584 1.00 33.49  ? 1555 ARG A CZ    1 
ATOM   6334 N  NH1   . ARG A 1 1210 ? 162.579 161.990 132.925 1.00 31.38  ? 1555 ARG A NH1   1 
ATOM   6335 N  NH2   . ARG A 1 1210 ? 164.725 161.603 133.620 1.00 35.22  ? 1555 ARG A NH2   1 
ATOM   6336 N  N     . SER A 1 1211 ? 157.824 155.616 135.542 1.00 24.69  ? 1556 SER A N     1 
ATOM   6337 C  CA    . SER A 1 1211 ? 156.524 155.281 136.107 1.00 13.15  ? 1556 SER A CA    1 
ATOM   6338 C  C     . SER A 1 1211 ? 156.672 154.428 137.354 1.00 28.46  ? 1556 SER A C     1 
ATOM   6339 O  O     . SER A 1 1211 ? 155.856 154.527 138.275 1.00 38.55  ? 1556 SER A O     1 
ATOM   6340 C  CB    . SER A 1 1211 ? 155.671 154.549 135.075 1.00 34.25  ? 1556 SER A CB    1 
ATOM   6341 O  OG    . SER A 1 1211 ? 156.081 153.199 134.953 1.00 39.89  ? 1556 SER A OG    1 
ATOM   6342 N  N     . GLN A 1 1212 ? 157.695 153.578 137.398 1.00 47.34  ? 1557 GLN A N     1 
ATOM   6343 C  CA    . GLN A 1 1212 ? 157.992 152.793 138.589 1.00 35.83  ? 1557 GLN A CA    1 
ATOM   6344 C  C     . GLN A 1 1212 ? 158.875 153.530 139.586 1.00 25.27  ? 1557 GLN A C     1 
ATOM   6345 O  O     . GLN A 1 1212 ? 159.176 152.979 140.646 1.00 40.88  ? 1557 GLN A O     1 
ATOM   6346 C  CB    . GLN A 1 1212 ? 158.658 151.469 138.208 1.00 18.26  ? 1557 GLN A CB    1 
ATOM   6347 C  CG    . GLN A 1 1212 ? 157.752 150.524 137.456 1.00 20.03  ? 1557 GLN A CG    1 
ATOM   6348 C  CD    . GLN A 1 1212 ? 157.220 149.420 138.334 1.00 28.45  ? 1557 GLN A CD    1 
ATOM   6349 O  OE1   . GLN A 1 1212 ? 156.252 149.605 139.066 1.00 39.42  ? 1557 GLN A OE1   1 
ATOM   6350 N  NE2   . GLN A 1 1212 ? 157.850 148.258 138.264 1.00 35.49  ? 1557 GLN A NE2   1 
ATOM   6351 N  N     . GLY A 1 1213 ? 159.300 154.751 139.279 1.00 10.05  ? 1558 GLY A N     1 
ATOM   6352 C  CA    . GLY A 1 1213 ? 160.122 155.502 140.200 1.00 21.38  ? 1558 GLY A CA    1 
ATOM   6353 C  C     . GLY A 1 1213 ? 161.583 155.126 140.218 1.00 17.08  ? 1558 GLY A C     1 
ATOM   6354 O  O     . GLY A 1 1213 ? 162.292 155.511 141.153 1.00 26.42  ? 1558 GLY A O     1 
ATOM   6355 N  N     . PHE A 1 1214 ? 162.058 154.389 139.222 1.00 21.12  ? 1559 PHE A N     1 
ATOM   6356 C  CA    . PHE A 1 1214 ? 163.458 153.993 139.192 1.00 29.42  ? 1559 PHE A CA    1 
ATOM   6357 C  C     . PHE A 1 1214 ? 164.341 155.200 138.887 1.00 30.51  ? 1559 PHE A C     1 
ATOM   6358 O  O     . PHE A 1 1214 ? 163.992 156.026 138.039 1.00 42.44  ? 1559 PHE A O     1 
ATOM   6359 C  CB    . PHE A 1 1214 ? 163.684 152.911 138.140 1.00 22.81  ? 1559 PHE A CB    1 
ATOM   6360 C  CG    . PHE A 1 1214 ? 163.392 151.531 138.629 1.00 19.88  ? 1559 PHE A CG    1 
ATOM   6361 C  CD1   . PHE A 1 1214 ? 164.334 150.824 139.341 1.00 27.84  ? 1559 PHE A CD1   1 
ATOM   6362 C  CD2   . PHE A 1 1214 ? 162.167 150.948 138.391 1.00 25.07  ? 1559 PHE A CD2   1 
ATOM   6363 C  CE1   . PHE A 1 1214 ? 164.063 149.561 139.795 1.00 31.19  ? 1559 PHE A CE1   1 
ATOM   6364 C  CE2   . PHE A 1 1214 ? 161.893 149.684 138.843 1.00 27.81  ? 1559 PHE A CE2   1 
ATOM   6365 C  CZ    . PHE A 1 1214 ? 162.842 148.991 139.546 1.00 28.11  ? 1559 PHE A CZ    1 
ATOM   6366 N  N     . PRO A 1 1215 ? 165.483 155.332 139.558 1.00 26.08  ? 1560 PRO A N     1 
ATOM   6367 C  CA    . PRO A 1 1215 ? 166.409 156.414 139.215 1.00 34.75  ? 1560 PRO A CA    1 
ATOM   6368 C  C     . PRO A 1 1215 ? 166.931 156.245 137.798 1.00 34.57  ? 1560 PRO A C     1 
ATOM   6369 O  O     . PRO A 1 1215 ? 167.061 155.129 137.292 1.00 54.45  ? 1560 PRO A O     1 
ATOM   6370 C  CB    . PRO A 1 1215 ? 167.532 156.267 140.248 1.00 29.01  ? 1560 PRO A CB    1 
ATOM   6371 C  CG    . PRO A 1 1215 ? 166.953 155.443 141.339 1.00 32.01  ? 1560 PRO A CG    1 
ATOM   6372 C  CD    . PRO A 1 1215 ? 165.963 154.534 140.695 1.00 29.06  ? 1560 PRO A CD    1 
ATOM   6373 N  N     . ASP A 1 1216 ? 167.226 157.371 137.151 1.00 34.91  ? 1561 ASP A N     1 
ATOM   6374 C  CA    . ASP A 1 1216 ? 167.729 157.319 135.784 1.00 41.19  ? 1561 ASP A CA    1 
ATOM   6375 C  C     . ASP A 1 1216 ? 169.093 156.653 135.678 1.00 51.00  ? 1561 ASP A C     1 
ATOM   6376 O  O     . ASP A 1 1216 ? 169.499 156.290 134.569 1.00 58.65  ? 1561 ASP A O     1 
ATOM   6377 C  CB    . ASP A 1 1216 ? 167.794 158.724 135.189 1.00 46.08  ? 1561 ASP A CB    1 
ATOM   6378 C  CG    . ASP A 1 1216 ? 166.526 159.512 135.426 1.00 54.48  ? 1561 ASP A CG    1 
ATOM   6379 O  OD1   . ASP A 1 1216 ? 166.552 160.445 136.251 1.00 56.68  ? 1561 ASP A OD1   1 
ATOM   6380 O  OD2   . ASP A 1 1216 ? 165.500 159.202 134.787 1.00 55.82  ? 1561 ASP A OD2   1 
ATOM   6381 N  N     . THR A 1 1217 ? 169.807 156.482 136.791 1.00 46.74  ? 1562 THR A N     1 
ATOM   6382 C  CA    . THR A 1 1217 ? 171.093 155.802 136.799 1.00 48.15  ? 1562 THR A CA    1 
ATOM   6383 C  C     . THR A 1 1217 ? 170.975 154.345 137.231 1.00 52.89  ? 1562 THR A C     1 
ATOM   6384 O  O     . THR A 1 1217 ? 171.944 153.776 137.743 1.00 62.04  ? 1562 THR A O     1 
ATOM   6385 C  CB    . THR A 1 1217 ? 172.079 156.542 137.701 1.00 49.06  ? 1562 THR A CB    1 
ATOM   6386 O  OG1   . THR A 1 1217 ? 173.322 155.833 137.734 1.00 59.29  ? 1562 THR A OG1   1 
ATOM   6387 C  CG2   . THR A 1 1217 ? 171.529 156.660 139.110 1.00 45.48  ? 1562 THR A CG2   1 
ATOM   6388 N  N     . TYR A 1 1218 ? 169.809 153.735 137.040 1.00 43.21  ? 1563 TYR A N     1 
ATOM   6389 C  CA    . TYR A 1 1218 ? 169.593 152.331 137.369 1.00 43.00  ? 1563 TYR A CA    1 
ATOM   6390 C  C     . TYR A 1 1218 ? 169.806 151.504 136.108 1.00 50.46  ? 1563 TYR A C     1 
ATOM   6391 O  O     . TYR A 1 1218 ? 168.966 151.512 135.203 1.00 60.55  ? 1563 TYR A O     1 
ATOM   6392 C  CB    . TYR A 1 1218 ? 168.191 152.124 137.932 1.00 47.03  ? 1563 TYR A CB    1 
ATOM   6393 C  CG    . TYR A 1 1218 ? 168.046 150.902 138.806 1.00 50.11  ? 1563 TYR A CG    1 
ATOM   6394 C  CD1   . TYR A 1 1218 ? 168.573 150.877 140.087 1.00 49.43  ? 1563 TYR A CD1   1 
ATOM   6395 C  CD2   . TYR A 1 1218 ? 167.372 149.779 138.353 1.00 48.24  ? 1563 TYR A CD2   1 
ATOM   6396 C  CE1   . TYR A 1 1218 ? 168.439 149.766 140.890 1.00 49.86  ? 1563 TYR A CE1   1 
ATOM   6397 C  CE2   . TYR A 1 1218 ? 167.228 148.664 139.150 1.00 49.87  ? 1563 TYR A CE2   1 
ATOM   6398 C  CZ    . TYR A 1 1218 ? 167.765 148.662 140.418 1.00 55.24  ? 1563 TYR A CZ    1 
ATOM   6399 O  OH    . TYR A 1 1218 ? 167.633 147.548 141.216 1.00 58.86  ? 1563 TYR A OH    1 
ATOM   6400 N  N     . ARG A 1 1219 ? 170.925 150.789 136.048 1.00 53.01  ? 1564 ARG A N     1 
ATOM   6401 C  CA    . ARG A 1 1219 ? 171.268 150.037 134.850 1.00 54.47  ? 1564 ARG A CA    1 
ATOM   6402 C  C     . ARG A 1 1219 ? 170.332 148.852 134.659 1.00 50.70  ? 1564 ARG A C     1 
ATOM   6403 O  O     . ARG A 1 1219 ? 169.916 148.202 135.621 1.00 50.18  ? 1564 ARG A O     1 
ATOM   6404 C  CB    . ARG A 1 1219 ? 172.712 149.551 134.926 1.00 54.12  ? 1564 ARG A CB    1 
ATOM   6405 C  CG    . ARG A 1 1219 ? 173.658 150.527 135.595 1.00 55.44  ? 1564 ARG A CG    1 
ATOM   6406 C  CD    . ARG A 1 1219 ? 174.062 151.634 134.640 1.00 54.68  ? 1564 ARG A CD    1 
ATOM   6407 N  NE    . ARG A 1 1219 ? 174.265 151.134 133.286 1.00 55.70  ? 1564 ARG A NE    1 
ATOM   6408 C  CZ    . ARG A 1 1219 ? 175.370 150.533 132.867 1.00 63.06  ? 1564 ARG A CZ    1 
ATOM   6409 N  NH1   . ARG A 1 1219 ? 176.403 150.347 133.672 1.00 62.99  ? 1564 ARG A NH1   1 
ATOM   6410 N  NH2   . ARG A 1 1219 ? 175.440 150.110 131.608 1.00 62.86  ? 1564 ARG A NH2   1 
ATOM   6411 N  N     . LEU A 1 1220 ? 170.003 148.577 133.399 1.00 48.94  ? 1565 LEU A N     1 
ATOM   6412 C  CA    . LEU A 1 1220 ? 169.214 147.420 133.011 1.00 43.72  ? 1565 LEU A CA    1 
ATOM   6413 C  C     . LEU A 1 1220 ? 169.972 146.655 131.937 1.00 53.80  ? 1565 LEU A C     1 
ATOM   6414 O  O     . LEU A 1 1220 ? 170.753 147.235 131.179 1.00 63.83  ? 1565 LEU A O     1 
ATOM   6415 C  CB    . LEU A 1 1220 ? 167.828 147.827 132.495 1.00 44.80  ? 1565 LEU A CB    1 
ATOM   6416 C  CG    . LEU A 1 1220 ? 166.997 148.741 133.397 1.00 45.49  ? 1565 LEU A CG    1 
ATOM   6417 C  CD1   . LEU A 1 1220 ? 166.300 149.810 132.575 1.00 47.96  ? 1565 LEU A CD1   1 
ATOM   6418 C  CD2   . LEU A 1 1220 ? 165.983 147.937 134.185 1.00 40.05  ? 1565 LEU A CD2   1 
ATOM   6419 N  N     . PHE A 1 1221 ? 169.742 145.346 131.878 1.00 50.99  ? 1566 PHE A N     1 
ATOM   6420 C  CA    . PHE A 1 1221 ? 170.490 144.469 130.989 1.00 49.82  ? 1566 PHE A CA    1 
ATOM   6421 C  C     . PHE A 1 1221 ? 169.537 143.625 130.159 1.00 52.13  ? 1566 PHE A C     1 
ATOM   6422 O  O     . PHE A 1 1221 ? 168.506 143.166 130.656 1.00 51.90  ? 1566 PHE A O     1 
ATOM   6423 C  CB    . PHE A 1 1221 ? 171.432 143.560 131.780 1.00 46.86  ? 1566 PHE A CB    1 
ATOM   6424 C  CG    . PHE A 1 1221 ? 172.405 142.806 130.927 1.00 46.05  ? 1566 PHE A CG    1 
ATOM   6425 C  CD1   . PHE A 1 1221 ? 173.629 143.356 130.601 1.00 49.70  ? 1566 PHE A CD1   1 
ATOM   6426 C  CD2   . PHE A 1 1221 ? 172.098 141.543 130.456 1.00 49.02  ? 1566 PHE A CD2   1 
ATOM   6427 C  CE1   . PHE A 1 1221 ? 174.526 142.663 129.821 1.00 54.78  ? 1566 PHE A CE1   1 
ATOM   6428 C  CE2   . PHE A 1 1221 ? 172.991 140.847 129.674 1.00 50.68  ? 1566 PHE A CE2   1 
ATOM   6429 C  CZ    . PHE A 1 1221 ? 174.206 141.407 129.356 1.00 52.08  ? 1566 PHE A CZ    1 
ATOM   6430 N  N     . GLY A 1 1222 ? 169.894 143.419 128.899 1.00 53.73  ? 1567 GLY A N     1 
ATOM   6431 C  CA    . GLY A 1 1222 ? 169.121 142.621 127.969 1.00 52.51  ? 1567 GLY A CA    1 
ATOM   6432 C  C     . GLY A 1 1222 ? 168.696 143.434 126.766 1.00 55.15  ? 1567 GLY A C     1 
ATOM   6433 O  O     . GLY A 1 1222 ? 169.113 144.580 126.572 1.00 60.16  ? 1567 GLY A O     1 
ATOM   6434 N  N     . ASN A 1 1223 ? 167.851 142.823 125.942 1.00 56.76  ? 1568 ASN A N     1 
ATOM   6435 C  CA    . ASN A 1 1223 ? 167.263 143.519 124.806 1.00 53.61  ? 1568 ASN A CA    1 
ATOM   6436 C  C     . ASN A 1 1223 ? 166.096 144.370 125.302 1.00 56.23  ? 1568 ASN A C     1 
ATOM   6437 O  O     . ASN A 1 1223 ? 165.894 144.546 126.506 1.00 62.52  ? 1568 ASN A O     1 
ATOM   6438 C  CB    . ASN A 1 1223 ? 166.847 142.525 123.726 1.00 57.94  ? 1568 ASN A CB    1 
ATOM   6439 C  CG    . ASN A 1 1223 ? 166.112 141.330 124.287 1.00 61.97  ? 1568 ASN A CG    1 
ATOM   6440 O  OD1   . ASN A 1 1223 ? 166.679 140.535 125.034 1.00 62.69  ? 1568 ASN A OD1   1 
ATOM   6441 N  ND2   . ASN A 1 1223 ? 164.844 141.191 123.924 1.00 60.31  ? 1568 ASN A ND2   1 
ATOM   6442 N  N     . ILE A 1 1224 ? 165.307 144.917 124.376 1.00 61.95  ? 1569 ILE A N     1 
ATOM   6443 C  CA    . ILE A 1 1224 ? 164.256 145.850 124.771 1.00 58.95  ? 1569 ILE A CA    1 
ATOM   6444 C  C     . ILE A 1 1224 ? 163.128 145.126 125.501 1.00 61.78  ? 1569 ILE A C     1 
ATOM   6445 O  O     . ILE A 1 1224 ? 162.598 145.629 126.499 1.00 71.62  ? 1569 ILE A O     1 
ATOM   6446 C  CB    . ILE A 1 1224 ? 163.746 146.631 123.548 1.00 53.82  ? 1569 ILE A CB    1 
ATOM   6447 C  CG1   . ILE A 1 1224 ? 162.650 147.606 123.965 1.00 58.60  ? 1569 ILE A CG1   1 
ATOM   6448 C  CG2   . ILE A 1 1224 ? 163.263 145.691 122.457 1.00 64.35  ? 1569 ILE A CG2   1 
ATOM   6449 C  CD1   . ILE A 1 1224 ? 162.087 148.390 122.818 1.00 64.20  ? 1569 ILE A CD1   1 
ATOM   6450 N  N     . LEU A 1 1225 ? 162.744 143.939 125.027 1.00 54.66  ? 1570 LEU A N     1 
ATOM   6451 C  CA    . LEU A 1 1225 ? 161.701 143.182 125.713 1.00 50.92  ? 1570 LEU A CA    1 
ATOM   6452 C  C     . LEU A 1 1225 ? 162.144 142.776 127.111 1.00 58.43  ? 1570 LEU A C     1 
ATOM   6453 O  O     . LEU A 1 1225 ? 161.355 142.827 128.061 1.00 61.89  ? 1570 LEU A O     1 
ATOM   6454 C  CB    . LEU A 1 1225 ? 161.315 141.954 124.893 1.00 51.05  ? 1570 LEU A CB    1 
ATOM   6455 C  CG    . LEU A 1 1225 ? 160.304 142.208 123.777 1.00 58.24  ? 1570 LEU A CG    1 
ATOM   6456 C  CD1   . LEU A 1 1225 ? 160.542 141.263 122.624 1.00 60.32  ? 1570 LEU A CD1   1 
ATOM   6457 C  CD2   . LEU A 1 1225 ? 158.887 142.065 124.299 1.00 61.76  ? 1570 LEU A CD2   1 
ATOM   6458 N  N     . ASP A 1 1226 ? 163.406 142.370 127.259 1.00 56.33  ? 1571 ASP A N     1 
ATOM   6459 C  CA    . ASP A 1 1226 ? 163.911 142.022 128.581 1.00 50.35  ? 1571 ASP A CA    1 
ATOM   6460 C  C     . ASP A 1 1226 ? 163.962 143.242 129.489 1.00 53.18  ? 1571 ASP A C     1 
ATOM   6461 O  O     . ASP A 1 1226 ? 163.689 143.138 130.688 1.00 58.67  ? 1571 ASP A O     1 
ATOM   6462 C  CB    . ASP A 1 1226 ? 165.288 141.375 128.466 1.00 53.40  ? 1571 ASP A CB    1 
ATOM   6463 C  CG    . ASP A 1 1226 ? 165.227 139.991 127.854 1.00 65.65  ? 1571 ASP A CG    1 
ATOM   6464 O  OD1   . ASP A 1 1226 ? 164.106 139.492 127.631 1.00 65.87  ? 1571 ASP A OD1   1 
ATOM   6465 O  OD2   . ASP A 1 1226 ? 166.297 139.400 127.603 1.00 68.32  ? 1571 ASP A OD2   1 
ATOM   6466 N  N     . LYS A 1 1227 ? 164.306 144.409 128.941 1.00 41.43  ? 1572 LYS A N     1 
ATOM   6467 C  CA    . LYS A 1 1227 ? 164.301 145.624 129.749 1.00 36.40  ? 1572 LYS A CA    1 
ATOM   6468 C  C     . LYS A 1 1227 ? 162.893 145.966 130.218 1.00 35.21  ? 1572 LYS A C     1 
ATOM   6469 O  O     . LYS A 1 1227 ? 162.688 146.336 131.381 1.00 46.67  ? 1572 LYS A O     1 
ATOM   6470 C  CB    . LYS A 1 1227 ? 164.905 146.781 128.956 1.00 34.23  ? 1572 LYS A CB    1 
ATOM   6471 C  CG    . LYS A 1 1227 ? 166.416 146.731 128.850 1.00 39.64  ? 1572 LYS A CG    1 
ATOM   6472 C  CD    . LYS A 1 1227 ? 166.965 147.959 128.157 1.00 44.43  ? 1572 LYS A CD    1 
ATOM   6473 C  CE    . LYS A 1 1227 ? 168.461 147.845 127.950 1.00 40.04  ? 1572 LYS A CE    1 
ATOM   6474 N  NZ    . LYS A 1 1227 ? 169.036 149.078 127.353 1.00 43.82  ? 1572 LYS A NZ    1 
ATOM   6475 N  N     . HIS A 1 1228 ? 161.907 145.842 129.328 1.00 43.99  ? 1573 HIS A N     1 
ATOM   6476 C  CA    . HIS A 1 1228 ? 160.525 146.100 129.720 1.00 46.34  ? 1573 HIS A CA    1 
ATOM   6477 C  C     . HIS A 1 1228 ? 160.062 145.114 130.782 1.00 47.86  ? 1573 HIS A C     1 
ATOM   6478 O  O     . HIS A 1 1228 ? 159.363 145.492 131.728 1.00 51.98  ? 1573 HIS A O     1 
ATOM   6479 C  CB    . HIS A 1 1228 ? 159.610 146.037 128.498 1.00 38.20  ? 1573 HIS A CB    1 
ATOM   6480 C  CG    . HIS A 1 1228 ? 159.483 147.338 127.772 1.00 37.77  ? 1573 HIS A CG    1 
ATOM   6481 N  ND1   . HIS A 1 1228 ? 159.060 148.495 128.387 1.00 50.81  ? 1573 HIS A ND1   1 
ATOM   6482 C  CD2   . HIS A 1 1228 ? 159.723 147.665 126.481 1.00 45.78  ? 1573 HIS A CD2   1 
ATOM   6483 C  CE1   . HIS A 1 1228 ? 159.047 149.480 127.508 1.00 45.03  ? 1573 HIS A CE1   1 
ATOM   6484 N  NE2   . HIS A 1 1228 ? 159.444 149.002 126.343 1.00 43.82  ? 1573 HIS A NE2   1 
ATOM   6485 N  N     . ARG A 1 1229 ? 160.435 143.840 130.638 1.00 47.47  ? 1574 ARG A N     1 
ATOM   6486 C  CA    . ARG A 1 1229 ? 160.062 142.844 131.636 1.00 44.60  ? 1574 ARG A CA    1 
ATOM   6487 C  C     . ARG A 1 1229 ? 160.709 143.141 132.983 1.00 45.03  ? 1574 ARG A C     1 
ATOM   6488 O  O     . ARG A 1 1229 ? 160.063 143.016 134.029 1.00 54.02  ? 1574 ARG A O     1 
ATOM   6489 C  CB    . ARG A 1 1229 ? 160.442 141.446 131.149 1.00 50.08  ? 1574 ARG A CB    1 
ATOM   6490 C  CG    . ARG A 1 1229 ? 160.583 140.418 132.255 1.00 54.59  ? 1574 ARG A CG    1 
ATOM   6491 C  CD    . ARG A 1 1229 ? 160.445 139.004 131.721 1.00 52.11  ? 1574 ARG A CD    1 
ATOM   6492 N  NE    . ARG A 1 1229 ? 159.072 138.525 131.805 1.00 61.65  ? 1574 ARG A NE    1 
ATOM   6493 C  CZ    . ARG A 1 1229 ? 158.239 138.459 130.777 1.00 60.63  ? 1574 ARG A CZ    1 
ATOM   6494 N  NH1   . ARG A 1 1229 ? 158.614 138.819 129.560 1.00 57.01  ? 1574 ARG A NH1   1 
ATOM   6495 N  NH2   . ARG A 1 1229 ? 156.998 138.022 130.974 1.00 60.49  ? 1574 ARG A NH2   1 
ATOM   6496 N  N     . GLN A 1 1230 ? 161.983 143.539 132.980 1.00 36.50  ? 1575 GLN A N     1 
ATOM   6497 C  CA    . GLN A 1 1230 ? 162.654 143.879 134.230 1.00 35.26  ? 1575 GLN A CA    1 
ATOM   6498 C  C     . GLN A 1 1230 ? 161.994 145.072 134.904 1.00 48.53  ? 1575 GLN A C     1 
ATOM   6499 O  O     . GLN A 1 1230 ? 161.801 145.075 136.125 1.00 46.17  ? 1575 GLN A O     1 
ATOM   6500 C  CB    . GLN A 1 1230 ? 164.128 144.176 133.973 1.00 31.81  ? 1575 GLN A CB    1 
ATOM   6501 C  CG    . GLN A 1 1230 ? 164.959 142.969 133.615 1.00 42.09  ? 1575 GLN A CG    1 
ATOM   6502 C  CD    . GLN A 1 1230 ? 166.303 143.352 133.043 1.00 42.45  ? 1575 GLN A CD    1 
ATOM   6503 O  OE1   . GLN A 1 1230 ? 167.028 144.159 133.621 1.00 36.40  ? 1575 GLN A OE1   1 
ATOM   6504 N  NE2   . GLN A 1 1230 ? 166.642 142.781 131.896 1.00 44.31  ? 1575 GLN A NE2   1 
ATOM   6505 N  N     . VAL A 1 1231 ? 161.649 146.100 134.128 1.00 50.47  ? 1576 VAL A N     1 
ATOM   6506 C  CA    . VAL A 1 1231 ? 161.061 147.303 134.710 1.00 30.60  ? 1576 VAL A CA    1 
ATOM   6507 C  C     . VAL A 1 1231 ? 159.661 147.017 135.239 1.00 36.83  ? 1576 VAL A C     1 
ATOM   6508 O  O     . VAL A 1 1231 ? 159.286 147.483 136.321 1.00 45.59  ? 1576 VAL A O     1 
ATOM   6509 C  CB    . VAL A 1 1231 ? 161.061 148.443 133.678 1.00 27.82  ? 1576 VAL A CB    1 
ATOM   6510 C  CG1   . VAL A 1 1231 ? 159.972 149.443 133.991 1.00 36.44  ? 1576 VAL A CG1   1 
ATOM   6511 C  CG2   . VAL A 1 1231 ? 162.415 149.123 133.647 1.00 33.89  ? 1576 VAL A CG2   1 
ATOM   6512 N  N     . GLY A 1 1232 ? 158.868 146.242 134.498 1.00 42.49  ? 1577 GLY A N     1 
ATOM   6513 C  CA    . GLY A 1 1232 ? 157.499 145.984 134.905 1.00 45.82  ? 1577 GLY A CA    1 
ATOM   6514 C  C     . GLY A 1 1232 ? 157.338 144.961 136.007 1.00 43.91  ? 1577 GLY A C     1 
ATOM   6515 O  O     . GLY A 1 1232 ? 156.263 144.883 136.608 1.00 46.62  ? 1577 GLY A O     1 
ATOM   6516 N  N     . ASN A 1 1233 ? 158.373 144.173 136.287 1.00 46.45  ? 1578 ASN A N     1 
ATOM   6517 C  CA    . ASN A 1 1233 ? 158.290 143.121 137.290 1.00 44.11  ? 1578 ASN A CA    1 
ATOM   6518 C  C     . ASN A 1 1233 ? 158.728 143.569 138.676 1.00 44.45  ? 1578 ASN A C     1 
ATOM   6519 O  O     . ASN A 1 1233 ? 158.688 142.762 139.609 1.00 55.09  ? 1578 ASN A O     1 
ATOM   6520 C  CB    . ASN A 1 1233 ? 159.144 141.920 136.872 1.00 42.89  ? 1578 ASN A CB    1 
ATOM   6521 C  CG    . ASN A 1 1233 ? 158.318 140.779 136.323 1.00 48.30  ? 1578 ASN A CG    1 
ATOM   6522 O  OD1   . ASN A 1 1233 ? 157.094 140.780 136.424 1.00 54.56  ? 1578 ASN A OD1   1 
ATOM   6523 N  ND2   . ASN A 1 1233 ? 158.986 139.791 135.744 1.00 44.23  ? 1578 ASN A ND2   1 
ATOM   6524 N  N     . ALA A 1 1234 ? 159.139 144.820 138.841 1.00 43.19  ? 1579 ALA A N     1 
ATOM   6525 C  CA    . ALA A 1 1234 ? 159.771 145.248 140.076 1.00 46.94  ? 1579 ALA A CA    1 
ATOM   6526 C  C     . ALA A 1 1234 ? 158.788 145.969 140.993 1.00 42.20  ? 1579 ALA A C     1 
ATOM   6527 O  O     . ALA A 1 1234 ? 157.656 146.284 140.623 1.00 49.16  ? 1579 ALA A O     1 
ATOM   6528 C  CB    . ALA A 1 1234 ? 160.964 146.149 139.774 1.00 44.17  ? 1579 ALA A CB    1 
ATOM   6529 N  N     . VAL A 1 1235 ? 159.243 146.221 142.211 1.00 34.85  ? 1580 VAL A N     1 
ATOM   6530 C  CA    . VAL A 1 1235 ? 158.490 146.972 143.211 1.00 42.09  ? 1580 VAL A CA    1 
ATOM   6531 C  C     . VAL A 1 1235 ? 158.972 148.418 143.173 1.00 55.31  ? 1580 VAL A C     1 
ATOM   6532 O  O     . VAL A 1 1235 ? 160.189 148.645 143.152 1.00 55.84  ? 1580 VAL A O     1 
ATOM   6533 C  CB    . VAL A 1 1235 ? 158.675 146.375 144.617 1.00 33.11  ? 1580 VAL A CB    1 
ATOM   6534 C  CG1   . VAL A 1 1235 ? 157.870 147.147 145.641 1.00 27.65  ? 1580 VAL A CG1   1 
ATOM   6535 C  CG2   . VAL A 1 1235 ? 158.286 144.911 144.619 1.00 43.73  ? 1580 VAL A CG2   1 
ATOM   6536 N  N     . PRO A 1 1236 ? 158.078 149.402 143.144 1.00 44.84  ? 1581 PRO A N     1 
ATOM   6537 C  CA    . PRO A 1 1236 ? 158.512 150.800 143.095 1.00 20.76  ? 1581 PRO A CA    1 
ATOM   6538 C  C     . PRO A 1 1236 ? 159.419 151.130 144.265 1.00 41.55  ? 1581 PRO A C     1 
ATOM   6539 O  O     . PRO A 1 1236 ? 159.052 150.914 145.429 1.00 60.23  ? 1581 PRO A O     1 
ATOM   6540 C  CB    . PRO A 1 1236 ? 157.196 151.589 143.165 1.00 29.40  ? 1581 PRO A CB    1 
ATOM   6541 C  CG    . PRO A 1 1236 ? 156.124 150.594 143.443 1.00 25.70  ? 1581 PRO A CG    1 
ATOM   6542 C  CD    . PRO A 1 1236 ? 156.621 149.270 143.000 1.00 37.49  ? 1581 PRO A CD    1 
ATOM   6543 N  N     . PRO A 1 1237 ? 160.617 151.635 143.994 1.00 24.90  ? 1582 PRO A N     1 
ATOM   6544 C  CA    . PRO A 1 1237 ? 161.578 151.910 145.061 1.00 40.16  ? 1582 PRO A CA    1 
ATOM   6545 C  C     . PRO A 1 1237 ? 161.061 152.896 146.097 1.00 53.41  ? 1582 PRO A C     1 
ATOM   6546 O  O     . PRO A 1 1237 ? 161.487 152.823 147.256 1.00 56.34  ? 1582 PRO A O     1 
ATOM   6547 C  CB    . PRO A 1 1237 ? 162.787 152.472 144.301 1.00 31.45  ? 1582 PRO A CB    1 
ATOM   6548 C  CG    . PRO A 1 1237 ? 162.722 151.792 143.000 1.00 24.12  ? 1582 PRO A CG    1 
ATOM   6549 C  CD    . PRO A 1 1237 ? 161.259 151.651 142.672 1.00 25.48  ? 1582 PRO A CD    1 
ATOM   6550 N  N     . PRO A 1 1238 ? 160.199 153.863 145.747 1.00 32.53  ? 1583 PRO A N     1 
ATOM   6551 C  CA    . PRO A 1 1238 ? 159.583 154.663 146.824 1.00 26.32  ? 1583 PRO A CA    1 
ATOM   6552 C  C     . PRO A 1 1238 ? 158.798 153.840 147.837 1.00 46.03  ? 1583 PRO A C     1 
ATOM   6553 O  O     . PRO A 1 1238 ? 158.884 154.104 149.045 1.00 57.93  ? 1583 PRO A O     1 
ATOM   6554 C  CB    . PRO A 1 1238 ? 158.674 155.642 146.068 1.00 39.21  ? 1583 PRO A CB    1 
ATOM   6555 C  CG    . PRO A 1 1238 ? 158.951 155.455 144.625 1.00 33.87  ? 1583 PRO A CG    1 
ATOM   6556 C  CD    . PRO A 1 1238 ? 160.136 154.583 144.465 1.00 36.38  ? 1583 PRO A CD    1 
ATOM   6557 N  N     . LEU A 1 1239 ? 158.039 152.841 147.384 1.00 35.22  ? 1584 LEU A N     1 
ATOM   6558 C  CA    . LEU A 1 1239 ? 157.286 152.003 148.314 1.00 33.88  ? 1584 LEU A CA    1 
ATOM   6559 C  C     . LEU A 1 1239 ? 158.219 151.195 149.210 1.00 41.31  ? 1584 LEU A C     1 
ATOM   6560 O  O     . LEU A 1 1239 ? 158.014 151.113 150.432 1.00 38.53  ? 1584 LEU A O     1 
ATOM   6561 C  CB    . LEU A 1 1239 ? 156.352 151.083 147.532 1.00 28.09  ? 1584 LEU A CB    1 
ATOM   6562 C  CG    . LEU A 1 1239 ? 155.497 150.088 148.308 1.00 33.20  ? 1584 LEU A CG    1 
ATOM   6563 C  CD1   . LEU A 1 1239 ? 154.500 150.820 149.171 1.00 44.58  ? 1584 LEU A CD1   1 
ATOM   6564 C  CD2   . LEU A 1 1239 ? 154.787 149.152 147.351 1.00 33.83  ? 1584 LEU A CD2   1 
ATOM   6565 N  N     . ALA A 1 1240 ? 159.255 150.598 148.618 1.00 35.77  ? 1585 ALA A N     1 
ATOM   6566 C  CA    . ALA A 1 1240 ? 160.239 149.872 149.406 1.00 36.61  ? 1585 ALA A CA    1 
ATOM   6567 C  C     . ALA A 1 1240 ? 160.968 150.795 150.369 1.00 42.16  ? 1585 ALA A C     1 
ATOM   6568 O  O     . ALA A 1 1240 ? 161.301 150.386 151.481 1.00 55.81  ? 1585 ALA A O     1 
ATOM   6569 C  CB    . ALA A 1 1240 ? 161.233 149.168 148.487 1.00 42.59  ? 1585 ALA A CB    1 
ATOM   6570 N  N     . LYS A 1 1241 ? 161.219 152.040 149.966 1.00 36.06  ? 1586 LYS A N     1 
ATOM   6571 C  CA    . LYS A 1 1241 ? 161.862 152.999 150.856 1.00 32.28  ? 1586 LYS A CA    1 
ATOM   6572 C  C     . LYS A 1 1241 ? 160.972 153.330 152.046 1.00 38.99  ? 1586 LYS A C     1 
ATOM   6573 O  O     . LYS A 1 1241 ? 161.459 153.448 153.175 1.00 45.33  ? 1586 LYS A O     1 
ATOM   6574 C  CB    . LYS A 1 1241 ? 162.222 154.265 150.083 1.00 31.06  ? 1586 LYS A CB    1 
ATOM   6575 C  CG    . LYS A 1 1241 ? 162.990 155.296 150.883 1.00 37.55  ? 1586 LYS A CG    1 
ATOM   6576 C  CD    . LYS A 1 1241 ? 163.288 156.521 150.038 1.00 41.39  ? 1586 LYS A CD    1 
ATOM   6577 C  CE    . LYS A 1 1241 ? 164.026 157.580 150.832 1.00 35.29  ? 1586 LYS A CE    1 
ATOM   6578 N  NZ    . LYS A 1 1241 ? 163.279 157.975 152.051 1.00 39.08  ? 1586 LYS A NZ    1 
ATOM   6579 N  N     . ALA A 1 1242 ? 159.667 153.485 151.817 1.00 38.79  ? 1587 ALA A N     1 
ATOM   6580 C  CA    . ALA A 1 1242 ? 158.754 153.729 152.932 1.00 36.45  ? 1587 ALA A CA    1 
ATOM   6581 C  C     . ALA A 1 1242 ? 158.732 152.548 153.898 1.00 43.50  ? 1587 ALA A C     1 
ATOM   6582 O  O     . ALA A 1 1242 ? 158.798 152.729 155.126 1.00 61.12  ? 1587 ALA A O     1 
ATOM   6583 C  CB    . ALA A 1 1242 ? 157.351 154.018 152.406 1.00 37.70  ? 1587 ALA A CB    1 
ATOM   6584 N  N     . ILE A 1 1243 ? 158.653 151.329 153.362 1.00 39.96  ? 1588 ILE A N     1 
ATOM   6585 C  CA    . ILE A 1 1243 ? 158.651 150.150 154.226 1.00 36.23  ? 1588 ILE A CA    1 
ATOM   6586 C  C     . ILE A 1 1243 ? 159.964 150.049 154.995 1.00 36.02  ? 1588 ILE A C     1 
ATOM   6587 O  O     . ILE A 1 1243 ? 159.984 149.720 156.190 1.00 45.76  ? 1588 ILE A O     1 
ATOM   6588 C  CB    . ILE A 1 1243 ? 158.376 148.883 153.399 1.00 41.70  ? 1588 ILE A CB    1 
ATOM   6589 C  CG1   . ILE A 1 1243 ? 157.017 148.992 152.709 1.00 40.41  ? 1588 ILE A CG1   1 
ATOM   6590 C  CG2   . ILE A 1 1243 ? 158.417 147.660 154.285 1.00 42.89  ? 1588 ILE A CG2   1 
ATOM   6591 C  CD1   . ILE A 1 1243 ? 156.735 147.871 151.743 1.00 35.01  ? 1588 ILE A CD1   1 
ATOM   6592 N  N     . GLY A 1 1244 ? 161.080 150.330 154.324 1.00 38.44  ? 1589 GLY A N     1 
ATOM   6593 C  CA    . GLY A 1 1244 ? 162.365 150.323 154.992 1.00 33.45  ? 1589 GLY A CA    1 
ATOM   6594 C  C     . GLY A 1 1244 ? 162.475 151.375 156.071 1.00 41.47  ? 1589 GLY A C     1 
ATOM   6595 O  O     . GLY A 1 1244 ? 163.137 151.157 157.081 1.00 49.93  ? 1589 GLY A O     1 
ATOM   6596 N  N     . LEU A 1 1245 ? 161.837 152.528 155.877 1.00 38.97  ? 1590 LEU A N     1 
ATOM   6597 C  CA    . LEU A 1 1245 ? 161.828 153.545 156.924 1.00 42.96  ? 1590 LEU A CA    1 
ATOM   6598 C  C     . LEU A 1 1245 ? 161.046 153.072 158.145 1.00 47.49  ? 1590 LEU A C     1 
ATOM   6599 O  O     . LEU A 1 1245 ? 161.451 153.321 159.290 1.00 56.04  ? 1590 LEU A O     1 
ATOM   6600 C  CB    . LEU A 1 1245 ? 161.252 154.849 156.380 1.00 38.67  ? 1590 LEU A CB    1 
ATOM   6601 C  CG    . LEU A 1 1245 ? 162.213 155.660 155.511 1.00 40.20  ? 1590 LEU A CG    1 
ATOM   6602 C  CD1   . LEU A 1 1245 ? 161.518 156.880 154.942 1.00 47.24  ? 1590 LEU A CD1   1 
ATOM   6603 C  CD2   . LEU A 1 1245 ? 163.440 156.064 156.306 1.00 45.48  ? 1590 LEU A CD2   1 
ATOM   6604 N  N     . GLU A 1 1246 ? 159.924 152.384 157.925 1.00 52.29  ? 1591 GLU A N     1 
ATOM   6605 C  CA    . GLU A 1 1246 ? 159.197 151.804 159.055 1.00 50.94  ? 1591 GLU A CA    1 
ATOM   6606 C  C     . GLU A 1 1246 ? 160.059 150.785 159.799 1.00 59.68  ? 1591 GLU A C     1 
ATOM   6607 O  O     . GLU A 1 1246 ? 160.134 150.790 161.039 1.00 65.46  ? 1591 GLU A O     1 
ATOM   6608 C  CB    . GLU A 1 1246 ? 157.899 151.160 158.572 1.00 46.02  ? 1591 GLU A CB    1 
ATOM   6609 C  CG    . GLU A 1 1246 ? 156.881 152.150 158.051 1.00 53.51  ? 1591 GLU A CG    1 
ATOM   6610 C  CD    . GLU A 1 1246 ? 156.324 153.037 159.143 1.00 62.16  ? 1591 GLU A CD    1 
ATOM   6611 O  OE1   . GLU A 1 1246 ? 156.178 152.551 160.284 1.00 65.71  ? 1591 GLU A OE1   1 
ATOM   6612 O  OE2   . GLU A 1 1246 ? 156.031 154.218 158.862 1.00 62.17  ? 1591 GLU A OE2   1 
ATOM   6613 N  N     . ILE A 1 1247 ? 160.735 149.910 159.052 1.00 48.70  ? 1592 ILE A N     1 
ATOM   6614 C  CA    . ILE A 1 1247 ? 161.605 148.925 159.689 1.00 37.27  ? 1592 ILE A CA    1 
ATOM   6615 C  C     . ILE A 1 1247 ? 162.755 149.616 160.410 1.00 39.56  ? 1592 ILE A C     1 
ATOM   6616 O  O     . ILE A 1 1247 ? 163.208 149.151 161.460 1.00 43.63  ? 1592 ILE A O     1 
ATOM   6617 C  CB    . ILE A 1 1247 ? 162.103 147.902 158.650 1.00 34.85  ? 1592 ILE A CB    1 
ATOM   6618 C  CG1   . ILE A 1 1247 ? 160.958 146.985 158.229 1.00 34.88  ? 1592 ILE A CG1   1 
ATOM   6619 C  CG2   . ILE A 1 1247 ? 163.229 147.064 159.211 1.00 46.95  ? 1592 ILE A CG2   1 
ATOM   6620 C  CD1   . ILE A 1 1247 ? 161.240 146.200 156.982 1.00 34.09  ? 1592 ILE A CD1   1 
ATOM   6621 N  N     . LYS A 1 1248 ? 163.244 150.731 159.863 1.00 47.24  ? 1593 LYS A N     1 
ATOM   6622 C  CA    . LYS A 1 1248 ? 164.275 151.514 160.534 1.00 52.74  ? 1593 LYS A CA    1 
ATOM   6623 C  C     . LYS A 1 1248 ? 163.785 152.020 161.877 1.00 55.28  ? 1593 LYS A C     1 
ATOM   6624 O  O     . LYS A 1 1248 ? 164.521 151.983 162.870 1.00 59.97  ? 1593 LYS A O     1 
ATOM   6625 C  CB    . LYS A 1 1248 ? 164.691 152.691 159.657 1.00 50.44  ? 1593 LYS A CB    1 
ATOM   6626 C  CG    . LYS A 1 1248 ? 166.015 153.311 160.031 1.00 52.33  ? 1593 LYS A CG    1 
ATOM   6627 C  CD    . LYS A 1 1248 ? 166.209 154.629 159.309 1.00 53.32  ? 1593 LYS A CD    1 
ATOM   6628 C  CE    . LYS A 1 1248 ? 167.632 155.133 159.453 1.00 57.21  ? 1593 LYS A CE    1 
ATOM   6629 N  NZ    . LYS A 1 1248 ? 167.849 156.384 158.677 1.00 60.93  ? 1593 LYS A NZ    1 
ATOM   6630 N  N     . LEU A 1 1249 ? 162.546 152.513 161.924 1.00 58.15  ? 1594 LEU A N     1 
ATOM   6631 C  CA    . LEU A 1 1249 ? 161.976 152.922 163.203 1.00 61.15  ? 1594 LEU A CA    1 
ATOM   6632 C  C     . LEU A 1 1249 ? 161.941 151.754 164.178 1.00 64.13  ? 1594 LEU A C     1 
ATOM   6633 O  O     . LEU A 1 1249 ? 162.256 151.914 165.364 1.00 67.19  ? 1594 LEU A O     1 
ATOM   6634 C  CB    . LEU A 1 1249 ? 160.573 153.493 163.004 1.00 60.14  ? 1594 LEU A CB    1 
ATOM   6635 C  CG    . LEU A 1 1249 ? 160.453 154.759 162.157 1.00 63.62  ? 1594 LEU A CG    1 
ATOM   6636 C  CD1   . LEU A 1 1249 ? 159.043 155.319 162.244 1.00 62.87  ? 1594 LEU A CD1   1 
ATOM   6637 C  CD2   . LEU A 1 1249 ? 161.473 155.799 162.588 1.00 65.87  ? 1594 LEU A CD2   1 
ATOM   6638 N  N     . CYS A 1 1250 ? 161.576 150.566 163.692 1.00 69.88  ? 1595 CYS A N     1 
ATOM   6639 C  CA    . CYS A 1 1250 ? 161.503 149.402 164.577 1.00 69.52  ? 1595 CYS A CA    1 
ATOM   6640 C  C     . CYS A 1 1250 ? 162.876 149.025 165.135 1.00 72.31  ? 1595 CYS A C     1 
ATOM   6641 O  O     . CYS A 1 1250 ? 163.024 148.778 166.340 1.00 72.56  ? 1595 CYS A O     1 
ATOM   6642 C  CB    . CYS A 1 1250 ? 160.880 148.223 163.839 1.00 69.86  ? 1595 CYS A CB    1 
ATOM   6643 S  SG    . CYS A 1 1250 ? 159.150 148.488 163.454 1.00 87.08  ? 1595 CYS A SG    1 
ATOM   6644 N  N     . MET A 1 1251 ? 163.893 148.963 164.271 1.00 79.14  ? 1596 MET A N     1 
ATOM   6645 C  CA    . MET A 1 1251 ? 165.235 148.626 164.746 1.00 72.19  ? 1596 MET A CA    1 
ATOM   6646 C  C     . MET A 1 1251 ? 165.773 149.696 165.684 1.00 73.02  ? 1596 MET A C     1 
ATOM   6647 O  O     . MET A 1 1251 ? 166.464 149.383 166.659 1.00 74.71  ? 1596 MET A O     1 
ATOM   6648 C  CB    . MET A 1 1251 ? 166.206 148.414 163.581 1.00 65.70  ? 1596 MET A CB    1 
ATOM   6649 C  CG    . MET A 1 1251 ? 165.645 147.697 162.378 1.00 66.98  ? 1596 MET A CG    1 
ATOM   6650 S  SD    . MET A 1 1251 ? 166.910 147.370 161.140 1.00 80.48  ? 1596 MET A SD    1 
ATOM   6651 C  CE    . MET A 1 1251 ? 167.808 148.917 161.150 1.00 69.88  ? 1596 MET A CE    1 
ATOM   6652 N  N     . LEU A 1 1252 ? 165.479 150.967 165.403 1.00 77.29  ? 1597 LEU A N     1 
ATOM   6653 C  CA    . LEU A 1 1252 ? 165.907 152.032 166.301 1.00 79.21  ? 1597 LEU A CA    1 
ATOM   6654 C  C     . LEU A 1 1252 ? 165.261 151.882 167.671 1.00 85.28  ? 1597 LEU A C     1 
ATOM   6655 O  O     . LEU A 1 1252 ? 165.923 152.065 168.700 1.00 91.92  ? 1597 LEU A O     1 
ATOM   6656 C  CB    . LEU A 1 1252 ? 165.576 153.393 165.691 1.00 79.73  ? 1597 LEU A CB    1 
ATOM   6657 C  CG    . LEU A 1 1252 ? 165.907 154.623 166.536 1.00 85.22  ? 1597 LEU A CG    1 
ATOM   6658 C  CD1   . LEU A 1 1252 ? 167.362 154.602 166.972 1.00 85.04  ? 1597 LEU A CD1   1 
ATOM   6659 C  CD2   . LEU A 1 1252 ? 165.594 155.896 165.765 1.00 84.81  ? 1597 LEU A CD2   1 
ATOM   6660 N  N     . ALA A 1 1253 ? 163.971 151.540 167.706 1.00 85.97  ? 1598 ALA A N     1 
ATOM   6661 C  CA    . ALA A 1 1253 ? 163.302 151.328 168.986 1.00 87.26  ? 1598 ALA A CA    1 
ATOM   6662 C  C     . ALA A 1 1253 ? 163.915 150.157 169.743 1.00 87.29  ? 1598 ALA A C     1 
ATOM   6663 O  O     . ALA A 1 1253 ? 164.139 150.241 170.958 1.00 86.58  ? 1598 ALA A O     1 
ATOM   6664 C  CB    . ALA A 1 1253 ? 161.807 151.101 168.768 1.00 86.85  ? 1598 ALA A CB    1 
ATOM   6665 N  N     . LYS A 1 1254 ? 164.194 149.054 169.043 1.00 85.98  ? 1599 LYS A N     1 
ATOM   6666 C  CA    . LYS A 1 1254 ? 164.797 147.904 169.711 1.00 87.14  ? 1599 LYS A CA    1 
ATOM   6667 C  C     . LYS A 1 1254 ? 166.181 148.240 170.252 1.00 88.85  ? 1599 LYS A C     1 
ATOM   6668 O  O     . LYS A 1 1254 ? 166.534 147.838 171.366 1.00 89.74  ? 1599 LYS A O     1 
ATOM   6669 C  CB    . LYS A 1 1254 ? 164.874 146.708 168.764 1.00 86.42  ? 1599 LYS A CB    1 
ATOM   6670 C  CG    . LYS A 1 1254 ? 165.430 145.459 169.429 1.00 85.24  ? 1599 LYS A CG    1 
ATOM   6671 C  CD    . LYS A 1 1254 ? 165.800 144.393 168.419 1.00 86.89  ? 1599 LYS A CD    1 
ATOM   6672 C  CE    . LYS A 1 1254 ? 166.550 143.252 169.085 1.00 86.17  ? 1599 LYS A CE    1 
ATOM   6673 N  NZ    . LYS A 1 1254 ? 165.828 142.748 170.282 1.00 86.96  ? 1599 LYS A NZ    1 
ATOM   6674 N  N     . ALA A 1 1255 ? 166.981 148.977 169.478 1.00 96.23  ? 1600 ALA A N     1 
ATOM   6675 C  CA    . ALA A 1 1255 ? 168.308 149.364 169.944 1.00 95.77  ? 1600 ALA A CA    1 
ATOM   6676 C  C     . ALA A 1 1255 ? 168.222 150.291 171.150 1.00 96.08  ? 1600 ALA A C     1 
ATOM   6677 O  O     . ALA A 1 1255 ? 169.014 150.169 172.091 1.00 96.79  ? 1600 ALA A O     1 
ATOM   6678 C  CB    . ALA A 1 1255 ? 169.090 150.028 168.812 1.00 93.04  ? 1600 ALA A CB    1 
ATOM   6679 N  N     . ARG A 1 1256 ? 167.273 151.229 171.135 1.00 104.68 ? 1601 ARG A N     1 
ATOM   6680 C  CA    . ARG A 1 1256 ? 167.091 152.110 172.282 1.00 103.47 ? 1601 ARG A CA    1 
ATOM   6681 C  C     . ARG A 1 1256 ? 166.693 151.320 173.522 1.00 104.68 ? 1601 ARG A C     1 
ATOM   6682 O  O     . ARG A 1 1256 ? 167.168 151.605 174.628 1.00 106.88 ? 1601 ARG A O     1 
ATOM   6683 C  CB    . ARG A 1 1256 ? 166.044 153.177 171.964 1.00 104.17 ? 1601 ARG A CB    1 
ATOM   6684 C  CG    . ARG A 1 1256 ? 166.521 154.244 170.993 1.00 103.00 ? 1601 ARG A CG    1 
ATOM   6685 C  CD    . ARG A 1 1256 ? 165.887 155.588 171.305 1.00 104.34 ? 1601 ARG A CD    1 
ATOM   6686 N  NE    . ARG A 1 1256 ? 164.448 155.478 171.511 1.00 107.25 ? 1601 ARG A NE    1 
ATOM   6687 C  CZ    . ARG A 1 1256 ? 163.536 155.788 170.600 1.00 108.75 ? 1601 ARG A CZ    1 
ATOM   6688 N  NH1   . ARG A 1 1256 ? 163.878 156.236 169.403 1.00 106.76 ? 1601 ARG A NH1   1 
ATOM   6689 N  NH2   . ARG A 1 1256 ? 162.247 155.648 170.898 1.00 109.72 ? 1601 ARG A NH2   1 
ATOM   6690 N  N     . GLU A 1 1257 ? 165.819 150.324 173.361 1.00 104.72 ? 1602 GLU A N     1 
ATOM   6691 C  CA    . GLU A 1 1257 ? 165.442 149.494 174.501 1.00 106.92 ? 1602 GLU A CA    1 
ATOM   6692 C  C     . GLU A 1 1257 ? 166.630 148.679 175.001 1.00 107.30 ? 1602 GLU A C     1 
ATOM   6693 O  O     . GLU A 1 1257 ? 166.798 148.497 176.213 1.00 107.98 ? 1602 GLU A O     1 
ATOM   6694 C  CB    . GLU A 1 1257 ? 164.234 148.617 174.131 1.00 106.58 ? 1602 GLU A CB    1 
ATOM   6695 C  CG    . GLU A 1 1257 ? 163.901 147.390 175.020 1.00 106.45 ? 1602 GLU A CG    1 
ATOM   6696 C  CD    . GLU A 1 1257 ? 164.884 146.228 174.930 1.00 106.34 ? 1602 GLU A CD    1 
ATOM   6697 O  OE1   . GLU A 1 1257 ? 164.761 145.284 175.742 1.00 106.02 ? 1602 GLU A OE1   1 
ATOM   6698 O  OE2   . GLU A 1 1257 ? 165.725 146.211 174.011 1.00 107.14 ? 1602 GLU A OE2   1 
ATOM   6699 N  N     . SER A 1 1258 ? 167.460 148.177 174.085 1.00 107.92 ? 1603 SER A N     1 
ATOM   6700 C  CA    . SER A 1 1258 ? 168.621 147.386 174.483 1.00 108.43 ? 1603 SER A CA    1 
ATOM   6701 C  C     . SER A 1 1258 ? 169.674 148.234 175.185 1.00 109.81 ? 1603 SER A C     1 
ATOM   6702 O  O     . SER A 1 1258 ? 170.370 147.736 176.078 1.00 108.55 ? 1603 SER A O     1 
ATOM   6703 C  CB    . SER A 1 1258 ? 169.226 146.694 173.262 1.00 107.54 ? 1603 SER A CB    1 
ATOM   6704 O  OG    . SER A 1 1258 ? 170.439 146.040 173.591 1.00 109.92 ? 1603 SER A OG    1 
ATOM   6705 N  N     . ALA A 1 1259 ? 169.815 149.503 174.795 1.00 117.09 ? 1604 ALA A N     1 
ATOM   6706 C  CA    . ALA A 1 1259 ? 170.815 150.361 175.424 1.00 116.59 ? 1604 ALA A CA    1 
ATOM   6707 C  C     . ALA A 1 1259 ? 170.518 150.564 176.904 1.00 116.39 ? 1604 ALA A C     1 
ATOM   6708 O  O     . ALA A 1 1259 ? 171.432 150.552 177.737 1.00 117.37 ? 1604 ALA A O     1 
ATOM   6709 C  CB    . ALA A 1 1259 ? 170.887 151.705 174.699 1.00 115.41 ? 1604 ALA A CB    1 
ATOM   6710 N  N     . SER A 1 1260 ? 169.249 150.749 177.250 1.00 118.32 ? 1605 SER A N     1 
ATOM   6711 C  CA    . SER A 1 1260 ? 168.858 150.944 178.639 1.00 119.34 ? 1605 SER A CA    1 
ATOM   6712 C  C     . SER A 1 1260 ? 167.537 150.247 178.936 1.00 118.71 ? 1605 SER A C     1 
ATOM   6713 O  O     . SER A 1 1260 ? 167.460 149.401 179.826 1.00 118.55 ? 1605 SER A O     1 
ATOM   6714 C  CB    . SER A 1 1260 ? 168.755 152.436 178.962 1.00 119.28 ? 1605 SER A CB    1 
ATOM   6715 O  OG    . SER A 1 1260 ? 167.828 153.082 178.108 1.00 119.91 ? 1605 SER A OG    1 
ATOM   6716 O  "O5'" . DA  B 2 1    ? 164.619 134.315 118.399 1.00 149.90 ? 1    DA  B "O5'" 1 
ATOM   6717 C  "C5'" . DA  B 2 1    ? 163.969 135.370 119.099 1.00 150.44 ? 1    DA  B "C5'" 1 
ATOM   6718 C  "C4'" . DA  B 2 1    ? 162.899 136.012 118.234 1.00 151.03 ? 1    DA  B "C4'" 1 
ATOM   6719 O  "O4'" . DA  B 2 1    ? 162.022 134.983 117.706 1.00 151.61 ? 1    DA  B "O4'" 1 
ATOM   6720 C  "C3'" . DA  B 2 1    ? 161.998 137.013 118.962 1.00 151.24 ? 1    DA  B "C3'" 1 
ATOM   6721 O  "O3'" . DA  B 2 1    ? 161.815 138.178 118.169 1.00 151.62 ? 1    DA  B "O3'" 1 
ATOM   6722 C  "C2'" . DA  B 2 1    ? 160.690 136.248 119.145 1.00 150.10 ? 1    DA  B "C2'" 1 
ATOM   6723 C  "C1'" . DA  B 2 1    ? 160.681 135.350 117.920 1.00 150.30 ? 1    DA  B "C1'" 1 
ATOM   6724 N  N9    . DA  B 2 1    ? 159.890 134.138 118.104 1.00 149.63 ? 1    DA  B N9    1 
ATOM   6725 C  C8    . DA  B 2 1    ? 160.112 133.140 119.011 1.00 148.31 ? 1    DA  B C8    1 
ATOM   6726 N  N7    . DA  B 2 1    ? 159.229 132.171 118.958 1.00 148.54 ? 1    DA  B N7    1 
ATOM   6727 C  C5    . DA  B 2 1    ? 158.366 132.563 117.948 1.00 150.12 ? 1    DA  B C5    1 
ATOM   6728 C  C6    . DA  B 2 1    ? 157.214 131.968 117.400 1.00 149.97 ? 1    DA  B C6    1 
ATOM   6729 N  N6    . DA  B 2 1    ? 156.720 130.799 117.819 1.00 148.76 ? 1    DA  B N6    1 
ATOM   6730 N  N1    . DA  B 2 1    ? 156.587 132.622 116.400 1.00 150.27 ? 1    DA  B N1    1 
ATOM   6731 C  C2    . DA  B 2 1    ? 157.085 133.792 115.983 1.00 149.63 ? 1    DA  B C2    1 
ATOM   6732 N  N3    . DA  B 2 1    ? 158.158 134.449 116.420 1.00 149.63 ? 1    DA  B N3    1 
ATOM   6733 C  C4    . DA  B 2 1    ? 158.760 133.773 117.410 1.00 150.31 ? 1    DA  B C4    1 
ATOM   6734 P  P     . DC  B 2 2    ? 161.057 139.455 118.781 1.00 147.65 ? 2    DC  B P     1 
ATOM   6735 O  OP1   . DC  B 2 2    ? 161.707 140.671 118.245 1.00 143.40 ? 2    DC  B OP1   1 
ATOM   6736 O  OP2   . DC  B 2 2    ? 160.962 139.254 120.242 1.00 143.46 ? 2    DC  B OP2   1 
ATOM   6737 O  "O5'" . DC  B 2 2    ? 159.590 139.369 118.155 1.00 144.75 ? 2    DC  B "O5'" 1 
ATOM   6738 C  "C5'" . DC  B 2 2    ? 159.425 139.370 116.746 1.00 144.10 ? 2    DC  B "C5'" 1 
ATOM   6739 C  "C4'" . DC  B 2 2    ? 157.964 139.214 116.376 1.00 143.62 ? 2    DC  B "C4'" 1 
ATOM   6740 O  "O4'" . DC  B 2 2    ? 157.547 137.855 116.618 1.00 145.14 ? 2    DC  B "O4'" 1 
ATOM   6741 C  "C3'" . DC  B 2 2    ? 157.004 140.110 117.160 1.00 141.64 ? 2    DC  B "C3'" 1 
ATOM   6742 O  "O3'" . DC  B 2 2    ? 156.347 140.998 116.272 1.00 140.68 ? 2    DC  B "O3'" 1 
ATOM   6743 C  "C2'" . DC  B 2 2    ? 156.023 139.140 117.836 1.00 141.69 ? 2    DC  B "C2'" 1 
ATOM   6744 C  "C1'" . DC  B 2 2    ? 156.215 137.848 117.056 1.00 143.48 ? 2    DC  B "C1'" 1 
ATOM   6745 N  N1    . DC  B 2 2    ? 156.011 136.608 117.868 1.00 144.01 ? 2    DC  B N1    1 
ATOM   6746 C  C2    . DC  B 2 2    ? 154.912 135.779 117.612 1.00 144.44 ? 2    DC  B C2    1 
ATOM   6747 O  O2    . DC  B 2 2    ? 154.106 136.098 116.732 1.00 144.55 ? 2    DC  B O2    1 
ATOM   6748 N  N3    . DC  B 2 2    ? 154.759 134.650 118.346 1.00 143.25 ? 2    DC  B N3    1 
ATOM   6749 C  C4    . DC  B 2 2    ? 155.648 134.337 119.286 1.00 142.60 ? 2    DC  B C4    1 
ATOM   6750 N  N4    . DC  B 2 2    ? 155.452 133.212 119.981 1.00 140.93 ? 2    DC  B N4    1 
ATOM   6751 C  C5    . DC  B 2 2    ? 156.776 135.165 119.559 1.00 142.91 ? 2    DC  B C5    1 
ATOM   6752 C  C6    . DC  B 2 2    ? 156.920 136.275 118.829 1.00 141.92 ? 2    DC  B C6    1 
ATOM   6753 P  P     . DT  B 2 3    ? 155.255 142.039 116.822 1.00 139.71 ? 3    DT  B P     1 
ATOM   6754 O  OP1   . DT  B 2 3    ? 155.272 143.213 115.924 1.00 133.27 ? 3    DT  B OP1   1 
ATOM   6755 O  OP2   . DT  B 2 3    ? 155.479 142.227 118.272 1.00 132.93 ? 3    DT  B OP2   1 
ATOM   6756 O  "O5'" . DT  B 2 3    ? 153.876 141.263 116.623 1.00 134.14 ? 3    DT  B "O5'" 1 
ATOM   6757 C  "C5'" . DT  B 2 3    ? 153.627 140.576 115.404 1.00 131.28 ? 3    DT  B "C5'" 1 
ATOM   6758 C  "C4'" . DT  B 2 3    ? 152.200 140.070 115.354 1.00 131.09 ? 3    DT  B "C4'" 1 
ATOM   6759 O  "O4'" . DT  B 2 3    ? 152.122 138.764 115.982 1.00 129.42 ? 3    DT  B "O4'" 1 
ATOM   6760 C  "C3'" . DT  B 2 3    ? 151.184 140.954 116.069 1.00 127.11 ? 3    DT  B "C3'" 1 
ATOM   6761 O  "O3'" . DT  B 2 3    ? 150.000 141.041 115.301 1.00 127.05 ? 3    DT  B "O3'" 1 
ATOM   6762 C  "C2'" . DT  B 2 3    ? 150.954 140.224 117.389 1.00 126.89 ? 3    DT  B "C2'" 1 
ATOM   6763 C  "C1'" . DT  B 2 3    ? 151.134 138.770 116.988 1.00 127.23 ? 3    DT  B "C1'" 1 
ATOM   6764 N  N1    . DT  B 2 3    ? 151.605 137.887 118.104 1.00 127.42 ? 3    DT  B N1    1 
ATOM   6765 C  C2    . DT  B 2 3    ? 150.944 136.707 118.357 1.00 127.95 ? 3    DT  B C2    1 
ATOM   6766 O  O2    . DT  B 2 3    ? 149.971 136.338 117.727 1.00 130.10 ? 3    DT  B O2    1 
ATOM   6767 N  N3    . DT  B 2 3    ? 151.469 135.971 119.388 1.00 128.13 ? 3    DT  B N3    1 
ATOM   6768 C  C4    . DT  B 2 3    ? 152.561 136.285 120.169 1.00 130.08 ? 3    DT  B C4    1 
ATOM   6769 O  O4    . DT  B 2 3    ? 152.955 135.558 121.072 1.00 132.84 ? 3    DT  B O4    1 
ATOM   6770 C  C5    . DT  B 2 3    ? 153.209 137.529 119.852 1.00 130.27 ? 3    DT  B C5    1 
ATOM   6771 C  C7    . DT  B 2 3    ? 154.404 137.969 120.642 1.00 130.75 ? 3    DT  B C7    1 
ATOM   6772 C  C6    . DT  B 2 3    ? 152.709 138.262 118.844 1.00 129.20 ? 3    DT  B C6    1 
ATOM   6773 P  P     . DT  B 2 4    ? 148.808 142.022 115.748 1.00 120.48 ? 4    DT  B P     1 
ATOM   6774 O  OP1   . DT  B 2 4    ? 148.362 142.749 114.540 1.00 114.67 ? 4    DT  B OP1   1 
ATOM   6775 O  OP2   . DT  B 2 4    ? 149.242 142.786 116.937 1.00 111.77 ? 4    DT  B OP2   1 
ATOM   6776 O  "O5'" . DT  B 2 4    ? 147.655 141.013 116.195 1.00 118.91 ? 4    DT  B "O5'" 1 
ATOM   6777 C  "C5'" . DT  B 2 4    ? 147.350 139.898 115.372 1.00 113.84 ? 4    DT  B "C5'" 1 
ATOM   6778 C  "C4'" . DT  B 2 4    ? 146.585 138.838 116.141 1.00 111.23 ? 4    DT  B "C4'" 1 
ATOM   6779 O  "O4'" . DT  B 2 4    ? 147.445 138.224 117.138 1.00 112.34 ? 4    DT  B "O4'" 1 
ATOM   6780 C  "C3'" . DT  B 2 4    ? 145.357 139.337 116.900 1.00 109.47 ? 4    DT  B "C3'" 1 
ATOM   6781 O  "O3'" . DT  B 2 4    ? 144.317 138.407 116.733 1.00 107.29 ? 4    DT  B "O3'" 1 
ATOM   6782 C  "C2'" . DT  B 2 4    ? 145.843 139.363 118.350 1.00 110.93 ? 4    DT  B "C2'" 1 
ATOM   6783 C  "C1'" . DT  B 2 4    ? 146.734 138.141 118.349 1.00 108.50 ? 4    DT  B "C1'" 1 
ATOM   6784 N  N1    . DT  B 2 4    ? 147.712 138.067 119.473 1.00 106.72 ? 4    DT  B N1    1 
ATOM   6785 C  C2    . DT  B 2 4    ? 147.699 136.965 120.287 1.00 107.17 ? 4    DT  B C2    1 
ATOM   6786 O  O2    . DT  B 2 4    ? 146.909 136.050 120.154 1.00 107.64 ? 4    DT  B O2    1 
ATOM   6787 N  N3    . DT  B 2 4    ? 148.645 136.968 121.274 1.00 110.74 ? 4    DT  B N3    1 
ATOM   6788 C  C4    . DT  B 2 4    ? 149.588 137.943 121.520 1.00 110.24 ? 4    DT  B C4    1 
ATOM   6789 O  O4    . DT  B 2 4    ? 150.399 137.856 122.436 1.00 107.66 ? 4    DT  B O4    1 
ATOM   6790 C  C5    . DT  B 2 4    ? 149.555 139.071 120.628 1.00 110.94 ? 4    DT  B C5    1 
ATOM   6791 C  C7    . DT  B 2 4    ? 150.533 140.193 120.807 1.00 111.60 ? 4    DT  B C7    1 
ATOM   6792 C  C6    . DT  B 2 4    ? 148.630 139.080 119.654 1.00 111.19 ? 4    DT  B C6    1 
ATOM   6793 P  P     . DA  B 2 5    ? 142.820 138.898 116.438 1.00 91.96  ? 5    DA  B P     1 
ATOM   6794 O  OP1   . DA  B 2 5    ? 142.524 138.604 115.019 1.00 88.18  ? 5    DA  B OP1   1 
ATOM   6795 O  OP2   . DA  B 2 5    ? 142.692 140.279 116.947 1.00 90.86  ? 5    DA  B OP2   1 
ATOM   6796 O  "O5'" . DA  B 2 5    ? 141.941 137.937 117.357 1.00 93.72  ? 5    DA  B "O5'" 1 
ATOM   6797 C  "C5'" . DA  B 2 5    ? 142.352 136.593 117.545 1.00 88.97  ? 5    DA  B "C5'" 1 
ATOM   6798 C  "C4'" . DA  B 2 5    ? 141.641 135.962 118.725 1.00 84.63  ? 5    DA  B "C4'" 1 
ATOM   6799 O  "O4'" . DA  B 2 5    ? 142.568 135.772 119.823 1.00 85.78  ? 5    DA  B "O4'" 1 
ATOM   6800 C  "C3'" . DA  B 2 5    ? 140.475 136.754 119.282 1.00 82.22  ? 5    DA  B "C3'" 1 
ATOM   6801 O  "O3'" . DA  B 2 5    ? 139.437 135.850 119.634 1.00 82.33  ? 5    DA  B "O3'" 1 
ATOM   6802 C  "C2'" . DA  B 2 5    ? 141.078 137.479 120.492 1.00 83.64  ? 5    DA  B "C2'" 1 
ATOM   6803 C  "C1'" . DA  B 2 5    ? 142.176 136.528 120.953 1.00 84.71  ? 5    DA  B "C1'" 1 
ATOM   6804 N  N9    . DA  B 2 5    ? 143.374 137.200 121.454 1.00 86.75  ? 5    DA  B N9    1 
ATOM   6805 C  C8    . DA  B 2 5    ? 143.920 138.358 120.986 1.00 89.32  ? 5    DA  B C8    1 
ATOM   6806 N  N7    . DA  B 2 5    ? 145.028 138.707 121.594 1.00 89.57  ? 5    DA  B N7    1 
ATOM   6807 C  C5    . DA  B 2 5    ? 145.234 137.699 122.516 1.00 88.52  ? 5    DA  B C5    1 
ATOM   6808 C  C6    . DA  B 2 5    ? 146.245 137.482 123.473 1.00 90.39  ? 5    DA  B C6    1 
ATOM   6809 N  N6    . DA  B 2 5    ? 147.272 138.315 123.654 1.00 91.85  ? 5    DA  B N6    1 
ATOM   6810 N  N1    . DA  B 2 5    ? 146.158 136.375 124.239 1.00 90.55  ? 5    DA  B N1    1 
ATOM   6811 C  C2    . DA  B 2 5    ? 145.125 135.546 124.050 1.00 91.21  ? 5    DA  B C2    1 
ATOM   6812 N  N3    . DA  B 2 5    ? 144.116 135.644 123.182 1.00 91.31  ? 5    DA  B N3    1 
ATOM   6813 C  C4    . DA  B 2 5    ? 144.231 136.755 122.438 1.00 88.78  ? 5    DA  B C4    1 
HETATM 6814 N  N1    . 5CM B 2 6    ? 141.457 138.230 125.231 1.00 79.22  ? 6    5CM B N1    1 
HETATM 6815 C  C2    . 5CM B 2 6    ? 142.570 138.391 125.916 1.00 80.46  ? 6    5CM B C2    1 
HETATM 6816 N  N3    . 5CM B 2 6    ? 143.411 139.375 125.670 1.00 81.41  ? 6    5CM B N3    1 
HETATM 6817 C  C4    . 5CM B 2 6    ? 143.145 140.234 124.708 1.00 79.46  ? 6    5CM B C4    1 
HETATM 6818 C  C5    . 5CM B 2 6    ? 141.985 140.098 123.964 1.00 80.72  ? 6    5CM B C5    1 
HETATM 6819 C  C5A   . 5CM B 2 6    ? 141.662 141.083 122.845 1.00 77.41  ? 6    5CM B C5A   1 
HETATM 6820 C  C6    . 5CM B 2 6    ? 141.125 139.050 124.253 1.00 81.52  ? 6    5CM B C6    1 
HETATM 6821 O  O2    . 5CM B 2 6    ? 142.822 137.626 126.783 1.00 83.26  ? 6    5CM B O2    1 
HETATM 6822 N  N4    . 5CM B 2 6    ? 144.063 141.320 124.429 1.00 74.63  ? 6    5CM B N4    1 
HETATM 6823 C  "C1'" . 5CM B 2 6    ? 140.574 137.115 125.563 1.00 76.44  ? 6    5CM B "C1'" 1 
HETATM 6824 C  "C2'" . 5CM B 2 6    ? 139.470 137.543 126.013 1.00 77.85  ? 6    5CM B "C2'" 1 
HETATM 6825 C  "C3'" . 5CM B 2 6    ? 138.436 136.568 125.542 1.00 77.68  ? 6    5CM B "C3'" 1 
HETATM 6826 C  "C4'" . 5CM B 2 6    ? 139.175 135.653 124.532 1.00 76.74  ? 6    5CM B "C4'" 1 
HETATM 6827 O  "O4'" . 5CM B 2 6    ? 140.199 136.281 124.232 1.00 77.54  ? 6    5CM B "O4'" 1 
HETATM 6828 O  "O3'" . 5CM B 2 6    ? 137.980 135.804 126.586 1.00 86.10  ? 6    5CM B "O3'" 1 
HETATM 6829 C  "C5'" . 5CM B 2 6    ? 138.274 135.466 123.253 1.00 78.68  ? 6    5CM B "C5'" 1 
HETATM 6830 O  "O5'" . 5CM B 2 6    ? 139.077 135.772 122.158 1.00 81.60  ? 6    5CM B "O5'" 1 
HETATM 6831 P  P     . 5CM B 2 6    ? 138.352 136.215 120.755 1.00 85.05  ? 6    5CM B P     1 
HETATM 6832 O  OP1   . 5CM B 2 6    ? 137.115 135.387 120.513 1.00 84.87  ? 6    5CM B OP1   1 
HETATM 6833 O  OP2   . 5CM B 2 6    ? 138.021 137.685 120.728 1.00 84.70  ? 6    5CM B OP2   1 
ATOM   6834 P  P     . DG  B 2 7    ? 136.468 135.262 126.594 1.00 104.39 ? 7    DG  B P     1 
ATOM   6835 O  OP1   . DG  B 2 7    ? 136.280 134.397 125.411 1.00 96.40  ? 7    DG  B OP1   1 
ATOM   6836 O  OP2   . DG  B 2 7    ? 135.577 136.422 126.798 1.00 94.92  ? 7    DG  B OP2   1 
ATOM   6837 O  "O5'" . DG  B 2 7    ? 136.403 134.339 127.897 1.00 97.22  ? 7    DG  B "O5'" 1 
ATOM   6838 C  "C5'" . DG  B 2 7    ? 137.100 133.101 127.919 1.00 92.60  ? 7    DG  B "C5'" 1 
ATOM   6839 C  "C4'" . DG  B 2 7    ? 137.197 132.554 129.333 1.00 94.48  ? 7    DG  B "C4'" 1 
ATOM   6840 O  "O4'" . DG  B 2 7    ? 138.270 133.223 130.042 1.00 93.85  ? 7    DG  B "O4'" 1 
ATOM   6841 C  "C3'" . DG  B 2 7    ? 135.947 132.735 130.185 1.00 95.93  ? 7    DG  B "C3'" 1 
ATOM   6842 O  "O3'" . DG  B 2 7    ? 135.762 131.596 131.009 1.00 97.98  ? 7    DG  B "O3'" 1 
ATOM   6843 C  "C2'" . DG  B 2 7    ? 136.268 133.980 131.008 1.00 92.30  ? 7    DG  B "C2'" 1 
ATOM   6844 C  "C1'" . DG  B 2 7    ? 137.769 133.843 131.206 1.00 94.65  ? 7    DG  B "C1'" 1 
ATOM   6845 N  N9    . DG  B 2 7    ? 138.458 135.120 131.364 1.00 93.87  ? 7    DG  B N9    1 
ATOM   6846 C  C8    . DG  B 2 7    ? 138.449 136.176 130.489 1.00 89.49  ? 7    DG  B C8    1 
ATOM   6847 N  N7    . DG  B 2 7    ? 139.171 137.186 130.886 1.00 90.99  ? 7    DG  B N7    1 
ATOM   6848 C  C5    . DG  B 2 7    ? 139.696 136.770 132.101 1.00 93.09  ? 7    DG  B C5    1 
ATOM   6849 C  C6    . DG  B 2 7    ? 140.555 137.442 132.998 1.00 92.79  ? 7    DG  B C6    1 
ATOM   6850 O  O6    . DG  B 2 7    ? 141.037 138.576 132.894 1.00 94.12  ? 7    DG  B O6    1 
ATOM   6851 N  N1    . DG  B 2 7    ? 140.847 136.664 134.113 1.00 95.45  ? 7    DG  B N1    1 
ATOM   6852 C  C2    . DG  B 2 7    ? 140.370 135.396 134.332 1.00 95.10  ? 7    DG  B C2    1 
ATOM   6853 N  N2    . DG  B 2 7    ? 140.763 134.802 135.467 1.00 93.28  ? 7    DG  B N2    1 
ATOM   6854 N  N3    . DG  B 2 7    ? 139.564 134.753 133.499 1.00 98.81  ? 7    DG  B N3    1 
ATOM   6855 C  C4    . DG  B 2 7    ? 139.270 135.499 132.407 1.00 97.27  ? 7    DG  B C4    1 
ATOM   6856 P  P     . DG  B 2 8    ? 134.384 131.391 131.807 1.00 116.88 ? 8    DG  B P     1 
ATOM   6857 O  OP1   . DG  B 2 8    ? 134.218 129.942 132.053 1.00 112.04 ? 8    DG  B OP1   1 
ATOM   6858 O  OP2   . DG  B 2 8    ? 133.333 132.146 131.091 1.00 108.23 ? 8    DG  B OP2   1 
ATOM   6859 O  "O5'" . DG  B 2 8    ? 134.644 132.123 133.201 1.00 111.29 ? 8    DG  B "O5'" 1 
ATOM   6860 C  "C5'" . DG  B 2 8    ? 135.798 131.801 133.962 1.00 110.71 ? 8    DG  B "C5'" 1 
ATOM   6861 C  "C4'" . DG  B 2 8    ? 135.943 132.743 135.140 1.00 109.08 ? 8    DG  B "C4'" 1 
ATOM   6862 O  "O4'" . DG  B 2 8    ? 136.493 134.008 134.689 1.00 107.95 ? 8    DG  B "O4'" 1 
ATOM   6863 C  "C3'" . DG  B 2 8    ? 134.635 133.079 135.859 1.00 109.06 ? 8    DG  B "C3'" 1 
ATOM   6864 O  "O3'" . DG  B 2 8    ? 134.825 133.015 137.260 1.00 112.73 ? 8    DG  B "O3'" 1 
ATOM   6865 C  "C2'" . DG  B 2 8    ? 134.341 134.506 135.403 1.00 107.72 ? 8    DG  B "C2'" 1 
ATOM   6866 C  "C1'" . DG  B 2 8    ? 135.745 135.058 135.248 1.00 107.81 ? 8    DG  B "C1'" 1 
ATOM   6867 N  N9    . DG  B 2 8    ? 135.821 136.210 134.360 1.00 107.56 ? 8    DG  B N9    1 
ATOM   6868 C  C8    . DG  B 2 8    ? 135.133 136.396 133.188 1.00 108.93 ? 8    DG  B C8    1 
ATOM   6869 N  N7    . DG  B 2 8    ? 135.400 137.529 132.603 1.00 111.54 ? 8    DG  B N7    1 
ATOM   6870 C  C5    . DG  B 2 8    ? 136.325 138.134 133.442 1.00 110.92 ? 8    DG  B C5    1 
ATOM   6871 C  C6    . DG  B 2 8    ? 136.977 139.381 133.326 1.00 110.86 ? 8    DG  B C6    1 
ATOM   6872 O  O6    . DG  B 2 8    ? 136.862 140.226 132.428 1.00 109.26 ? 8    DG  B O6    1 
ATOM   6873 N  N1    . DG  B 2 8    ? 137.838 139.613 134.394 1.00 108.27 ? 8    DG  B N1    1 
ATOM   6874 C  C2    . DG  B 2 8    ? 138.042 138.748 135.439 1.00 107.06 ? 8    DG  B C2    1 
ATOM   6875 N  N2    . DG  B 2 8    ? 138.911 139.147 136.378 1.00 108.69 ? 8    DG  B N2    1 
ATOM   6876 N  N3    . DG  B 2 8    ? 137.436 137.576 135.561 1.00 108.46 ? 8    DG  B N3    1 
ATOM   6877 C  C4    . DG  B 2 8    ? 136.594 137.336 134.529 1.00 108.72 ? 8    DG  B C4    1 
ATOM   6878 P  P     . DA  B 2 9    ? 133.618 132.572 138.221 1.00 123.62 ? 9    DA  B P     1 
ATOM   6879 O  OP1   . DA  B 2 9    ? 133.584 131.093 138.246 1.00 121.39 ? 9    DA  B OP1   1 
ATOM   6880 O  OP2   . DA  B 2 9    ? 132.415 133.330 137.811 1.00 111.18 ? 9    DA  B OP2   1 
ATOM   6881 O  "O5'" . DA  B 2 9    ? 134.069 133.104 139.658 1.00 118.77 ? 9    DA  B "O5'" 1 
ATOM   6882 C  "C5'" . DA  B 2 9    ? 135.347 132.754 140.170 1.00 115.38 ? 9    DA  B "C5'" 1 
ATOM   6883 C  "C4'" . DA  B 2 9    ? 135.973 133.921 140.912 1.00 115.06 ? 9    DA  B "C4'" 1 
ATOM   6884 O  "O4'" . DA  B 2 9    ? 136.297 134.980 139.973 1.00 113.40 ? 9    DA  B "O4'" 1 
ATOM   6885 C  "C3'" . DA  B 2 9    ? 135.091 134.561 141.981 1.00 117.38 ? 9    DA  B "C3'" 1 
ATOM   6886 O  "O3'" . DA  B 2 9    ? 135.887 134.931 143.094 1.00 120.82 ? 9    DA  B "O3'" 1 
ATOM   6887 C  "C2'" . DA  B 2 9    ? 134.522 135.785 141.268 1.00 114.90 ? 9    DA  B "C2'" 1 
ATOM   6888 C  "C1'" . DA  B 2 9    ? 135.690 136.186 140.384 1.00 114.04 ? 9    DA  B "C1'" 1 
ATOM   6889 N  N9    . DA  B 2 9    ? 135.293 136.921 139.189 1.00 112.45 ? 9    DA  B N9    1 
ATOM   6890 C  C8    . DA  B 2 9    ? 134.433 136.502 138.216 1.00 115.34 ? 9    DA  B C8    1 
ATOM   6891 N  N7    . DA  B 2 9    ? 134.272 137.367 137.245 1.00 116.53 ? 9    DA  B N7    1 
ATOM   6892 C  C5    . DA  B 2 9    ? 135.086 138.425 137.604 1.00 114.50 ? 9    DA  B C5    1 
ATOM   6893 C  C6    . DA  B 2 9    ? 135.359 139.660 136.990 1.00 112.57 ? 9    DA  B C6    1 
ATOM   6894 N  N6    . DA  B 2 9    ? 134.812 140.040 135.833 1.00 112.31 ? 9    DA  B N6    1 
ATOM   6895 N  N1    . DA  B 2 9    ? 136.219 140.490 137.611 1.00 111.92 ? 9    DA  B N1    1 
ATOM   6896 C  C2    . DA  B 2 9    ? 136.766 140.103 138.767 1.00 113.64 ? 9    DA  B C2    1 
ATOM   6897 N  N3    . DA  B 2 9    ? 136.584 138.970 139.442 1.00 114.10 ? 9    DA  B N3    1 
ATOM   6898 C  C4    . DA  B 2 9    ? 135.725 138.167 138.799 1.00 113.59 ? 9    DA  B C4    1 
ATOM   6899 P  P     . DA  B 2 10   ? 135.197 135.356 144.480 1.00 125.98 ? 10   DA  B P     1 
ATOM   6900 O  OP1   . DA  B 2 10   ? 135.908 134.641 145.562 1.00 116.81 ? 10   DA  B OP1   1 
ATOM   6901 O  OP2   . DA  B 2 10   ? 133.734 135.200 144.331 1.00 118.83 ? 10   DA  B OP2   1 
ATOM   6902 O  "O5'" . DA  B 2 10   ? 135.520 136.917 144.598 1.00 115.11 ? 10   DA  B "O5'" 1 
ATOM   6903 C  "C5'" . DA  B 2 10   ? 136.868 137.363 144.543 1.00 113.10 ? 10   DA  B "C5'" 1 
ATOM   6904 C  "C4'" . DA  B 2 10   ? 136.961 138.869 144.724 1.00 111.57 ? 10   DA  B "C4'" 1 
ATOM   6905 O  "O4'" . DA  B 2 10   ? 136.703 139.538 143.464 1.00 112.17 ? 10   DA  B "O4'" 1 
ATOM   6906 C  "C3'" . DA  B 2 10   ? 135.979 139.477 145.716 1.00 114.06 ? 10   DA  B "C3'" 1 
ATOM   6907 O  "O3'" . DA  B 2 10   ? 136.589 140.592 146.331 1.00 113.78 ? 10   DA  B "O3'" 1 
ATOM   6908 C  "C2'" . DA  B 2 10   ? 134.831 139.911 144.808 1.00 114.73 ? 10   DA  B "C2'" 1 
ATOM   6909 C  "C1'" . DA  B 2 10   ? 135.613 140.427 143.615 1.00 115.44 ? 10   DA  B "C1'" 1 
ATOM   6910 N  N9    . DA  B 2 10   ? 134.875 140.444 142.359 1.00 119.68 ? 10   DA  B N9    1 
ATOM   6911 C  C8    . DA  B 2 10   ? 134.084 139.455 141.847 1.00 119.38 ? 10   DA  B C8    1 
ATOM   6912 N  N7    . DA  B 2 10   ? 133.581 139.739 140.668 1.00 117.06 ? 10   DA  B N7    1 
ATOM   6913 C  C5    . DA  B 2 10   ? 134.086 140.996 140.387 1.00 114.84 ? 10   DA  B C5    1 
ATOM   6914 C  C6    . DA  B 2 10   ? 133.933 141.859 139.283 1.00 115.09 ? 10   DA  B C6    1 
ATOM   6915 N  N6    . DA  B 2 10   ? 133.185 141.564 138.215 1.00 116.49 ? 10   DA  B N6    1 
ATOM   6916 N  N1    . DA  B 2 10   ? 134.580 143.041 139.322 1.00 117.28 ? 10   DA  B N1    1 
ATOM   6917 C  C2    . DA  B 2 10   ? 135.328 143.332 140.391 1.00 114.00 ? 10   DA  B C2    1 
ATOM   6918 N  N3    . DA  B 2 10   ? 135.547 142.605 141.481 1.00 112.88 ? 10   DA  B N3    1 
ATOM   6919 C  C4    . DA  B 2 10   ? 134.892 141.439 141.415 1.00 115.99 ? 10   DA  B C4    1 
ATOM   6920 P  P     . DG  B 2 11   ? 136.208 141.009 147.832 1.00 127.51 ? 11   DG  B P     1 
ATOM   6921 O  OP1   . DG  B 2 11   ? 137.449 140.915 148.631 1.00 118.54 ? 11   DG  B OP1   1 
ATOM   6922 O  OP2   . DG  B 2 11   ? 135.008 140.239 148.228 1.00 124.63 ? 11   DG  B OP2   1 
ATOM   6923 O  "O5'" . DG  B 2 11   ? 135.800 142.549 147.698 1.00 123.60 ? 11   DG  B "O5'" 1 
ATOM   6924 C  "C5'" . DG  B 2 11   ? 136.712 143.471 147.114 1.00 120.06 ? 11   DG  B "C5'" 1 
ATOM   6925 C  "C4'" . DG  B 2 11   ? 135.982 144.675 146.543 1.00 122.64 ? 11   DG  B "C4'" 1 
ATOM   6926 O  "O4'" . DG  B 2 11   ? 135.431 144.349 145.241 1.00 123.81 ? 11   DG  B "O4'" 1 
ATOM   6927 C  "C3'" . DG  B 2 11   ? 134.808 145.188 147.386 1.00 122.98 ? 11   DG  B "C3'" 1 
ATOM   6928 O  "O3'" . DG  B 2 11   ? 134.898 146.598 147.520 1.00 124.79 ? 11   DG  B "O3'" 1 
ATOM   6929 C  "C2'" . DG  B 2 11   ? 133.583 144.785 146.564 1.00 120.20 ? 11   DG  B "C2'" 1 
ATOM   6930 C  "C1'" . DG  B 2 11   ? 134.139 144.890 145.159 1.00 121.11 ? 11   DG  B "C1'" 1 
ATOM   6931 N  N9    . DG  B 2 11   ? 133.375 144.153 144.158 1.00 122.32 ? 11   DG  B N9    1 
ATOM   6932 C  C8    . DG  B 2 11   ? 132.869 142.880 144.261 1.00 121.51 ? 11   DG  B C8    1 
ATOM   6933 N  N7    . DG  B 2 11   ? 132.220 142.492 143.196 1.00 121.77 ? 11   DG  B N7    1 
ATOM   6934 C  C5    . DG  B 2 11   ? 132.301 143.581 142.336 1.00 122.55 ? 11   DG  B C5    1 
ATOM   6935 C  C6    . DG  B 2 11   ? 131.787 143.757 141.028 1.00 121.48 ? 11   DG  B C6    1 
ATOM   6936 O  O6    . DG  B 2 11   ? 131.130 142.961 140.342 1.00 121.23 ? 11   DG  B O6    1 
ATOM   6937 N  N1    . DG  B 2 11   ? 132.098 145.017 140.520 1.00 120.02 ? 11   DG  B N1    1 
ATOM   6938 C  C2    . DG  B 2 11   ? 132.815 145.978 141.190 1.00 119.76 ? 11   DG  B C2    1 
ATOM   6939 N  N2    . DG  B 2 11   ? 133.024 147.132 140.543 1.00 120.53 ? 11   DG  B N2    1 
ATOM   6940 N  N3    . DG  B 2 11   ? 133.300 145.823 142.409 1.00 119.79 ? 11   DG  B N3    1 
ATOM   6941 C  C4    . DG  B 2 11   ? 133.007 144.608 142.919 1.00 122.25 ? 11   DG  B C4    1 
ATOM   6942 P  P     . DG  B 2 12   ? 134.267 147.336 148.800 1.00 133.47 ? 12   DG  B P     1 
ATOM   6943 O  OP1   . DG  B 2 12   ? 135.383 147.983 149.525 1.00 126.65 ? 12   DG  B OP1   1 
ATOM   6944 O  OP2   . DG  B 2 12   ? 133.400 146.367 149.507 1.00 130.76 ? 12   DG  B OP2   1 
ATOM   6945 O  "O5'" . DG  B 2 12   ? 133.335 148.469 148.162 1.00 128.42 ? 12   DG  B "O5'" 1 
ATOM   6946 C  "C5'" . DG  B 2 12   ? 133.920 149.514 147.393 1.00 127.46 ? 12   DG  B "C5'" 1 
ATOM   6947 C  "C4'" . DG  B 2 12   ? 132.962 150.020 146.327 1.00 129.49 ? 12   DG  B "C4'" 1 
ATOM   6948 O  "O4'" . DG  B 2 12   ? 132.834 149.040 145.280 1.00 128.44 ? 12   DG  B "O4'" 1 
ATOM   6949 C  "C3'" . DG  B 2 12   ? 131.538 150.251 146.791 1.00 130.35 ? 12   DG  B "C3'" 1 
ATOM   6950 O  "O3'" . DG  B 2 12   ? 131.426 151.532 147.400 1.00 129.58 ? 12   DG  B "O3'" 1 
ATOM   6951 C  "C2'" . DG  B 2 12   ? 130.755 150.187 145.476 1.00 128.65 ? 12   DG  B "C2'" 1 
ATOM   6952 C  "C1'" . DG  B 2 12   ? 131.612 149.256 144.602 1.00 128.50 ? 12   DG  B "C1'" 1 
ATOM   6953 N  N9    . DG  B 2 12   ? 130.983 147.967 144.331 1.00 129.57 ? 12   DG  B N9    1 
ATOM   6954 C  C8    . DG  B 2 12   ? 130.925 146.875 145.162 1.00 127.96 ? 12   DG  B C8    1 
ATOM   6955 N  N7    . DG  B 2 12   ? 130.287 145.861 144.643 1.00 127.52 ? 12   DG  B N7    1 
ATOM   6956 C  C5    . DG  B 2 12   ? 129.896 146.313 143.389 1.00 127.15 ? 12   DG  B C5    1 
ATOM   6957 C  C6    . DG  B 2 12   ? 129.169 145.658 142.362 1.00 126.09 ? 12   DG  B C6    1 
ATOM   6958 O  O6    . DG  B 2 12   ? 128.708 144.509 142.356 1.00 125.45 ? 12   DG  B O6    1 
ATOM   6959 N  N1    . DG  B 2 12   ? 128.989 146.482 141.253 1.00 126.82 ? 12   DG  B N1    1 
ATOM   6960 C  C2    . DG  B 2 12   ? 129.453 147.772 141.150 1.00 127.58 ? 12   DG  B C2    1 
ATOM   6961 N  N2    . DG  B 2 12   ? 129.190 148.415 140.005 1.00 128.06 ? 12   DG  B N2    1 
ATOM   6962 N  N3    . DG  B 2 12   ? 130.134 148.392 142.101 1.00 128.28 ? 12   DG  B N3    1 
ATOM   6963 C  C4    . DG  B 2 12   ? 130.317 147.606 143.186 1.00 128.38 ? 12   DG  B C4    1 
ATOM   6964 O  "O5'" . DC  C 3 1    ? 123.615 144.826 134.621 1.00 122.44 ? 1    DC  C "O5'" 1 
ATOM   6965 C  "C5'" . DC  C 3 1    ? 123.237 146.064 134.030 1.00 124.08 ? 1    DC  C "C5'" 1 
ATOM   6966 C  "C4'" . DC  C 3 1    ? 124.243 147.154 134.360 1.00 124.40 ? 1    DC  C "C4'" 1 
ATOM   6967 O  "O4'" . DC  C 3 1    ? 124.553 147.114 135.779 1.00 125.01 ? 1    DC  C "O4'" 1 
ATOM   6968 C  "C3'" . DC  C 3 1    ? 125.586 147.037 133.645 1.00 126.34 ? 1    DC  C "C3'" 1 
ATOM   6969 O  "O3'" . DC  C 3 1    ? 126.119 148.336 133.413 1.00 126.41 ? 1    DC  C "O3'" 1 
ATOM   6970 C  "C2'" . DC  C 3 1    ? 126.424 146.266 134.657 1.00 124.16 ? 1    DC  C "C2'" 1 
ATOM   6971 C  "C1'" . DC  C 3 1    ? 125.934 146.878 135.959 1.00 123.87 ? 1    DC  C "C1'" 1 
ATOM   6972 N  N1    . DC  C 3 1    ? 126.110 145.999 137.152 1.00 125.11 ? 1    DC  C N1    1 
ATOM   6973 C  C2    . DC  C 3 1    ? 126.818 146.474 138.257 1.00 124.19 ? 1    DC  C C2    1 
ATOM   6974 O  O2    . DC  C 3 1    ? 127.292 147.613 138.216 1.00 121.00 ? 1    DC  C O2    1 
ATOM   6975 N  N3    . DC  C 3 1    ? 126.965 145.674 139.343 1.00 124.49 ? 1    DC  C N3    1 
ATOM   6976 C  C4    . DC  C 3 1    ? 126.434 144.451 139.343 1.00 124.07 ? 1    DC  C C4    1 
ATOM   6977 N  N4    . DC  C 3 1    ? 126.603 143.696 140.434 1.00 122.47 ? 1    DC  C N4    1 
ATOM   6978 C  C5    . DC  C 3 1    ? 125.704 143.948 138.226 1.00 124.71 ? 1    DC  C C5    1 
ATOM   6979 C  C6    . DC  C 3 1    ? 125.567 144.748 137.163 1.00 124.54 ? 1    DC  C C6    1 
ATOM   6980 P  P     . DC  C 3 2    ? 127.325 148.549 132.373 1.00 121.82 ? 2    DC  C P     1 
ATOM   6981 O  OP1   . DC  C 3 2    ? 126.948 149.672 131.488 1.00 111.72 ? 2    DC  C OP1   1 
ATOM   6982 O  OP2   . DC  C 3 2    ? 127.664 147.236 131.784 1.00 111.25 ? 2    DC  C OP2   1 
ATOM   6983 O  "O5'" . DC  C 3 2    ? 128.550 149.010 133.293 1.00 117.68 ? 2    DC  C "O5'" 1 
ATOM   6984 C  "C5'" . DC  C 3 2    ? 128.542 150.300 133.892 1.00 113.05 ? 2    DC  C "C5'" 1 
ATOM   6985 C  "C4'" . DC  C 3 2    ? 129.765 150.508 134.771 1.00 110.57 ? 2    DC  C "C4'" 1 
ATOM   6986 O  "O4'" . DC  C 3 2    ? 129.714 149.610 135.909 1.00 110.72 ? 2    DC  C "O4'" 1 
ATOM   6987 C  "C3'" . DC  C 3 2    ? 131.108 150.244 134.100 1.00 108.93 ? 2    DC  C "C3'" 1 
ATOM   6988 O  "O3'" . DC  C 3 2    ? 132.070 151.136 134.625 1.00 110.09 ? 2    DC  C "O3'" 1 
ATOM   6989 C  "C2'" . DC  C 3 2    ? 131.405 148.806 134.515 1.00 109.87 ? 2    DC  C "C2'" 1 
ATOM   6990 C  "C1'" . DC  C 3 2    ? 130.881 148.815 135.938 1.00 110.89 ? 2    DC  C "C1'" 1 
ATOM   6991 N  N1    . DC  C 3 2    ? 130.511 147.476 136.474 1.00 111.29 ? 2    DC  C N1    1 
ATOM   6992 C  C2    . DC  C 3 2    ? 130.890 147.134 137.771 1.00 111.87 ? 2    DC  C C2    1 
ATOM   6993 O  O2    . DC  C 3 2    ? 131.547 147.943 138.430 1.00 112.27 ? 2    DC  C O2    1 
ATOM   6994 N  N3    . DC  C 3 2    ? 130.530 145.930 138.270 1.00 111.17 ? 2    DC  C N3    1 
ATOM   6995 C  C4    . DC  C 3 2    ? 129.816 145.088 137.525 1.00 110.17 ? 2    DC  C C4    1 
ATOM   6996 N  N4    . DC  C 3 2    ? 129.485 143.907 138.060 1.00 108.91 ? 2    DC  C N4    1 
ATOM   6997 C  C5    . DC  C 3 2    ? 129.413 145.418 136.198 1.00 110.69 ? 2    DC  C C5    1 
ATOM   6998 C  C6    . DC  C 3 2    ? 129.774 146.614 135.718 1.00 110.30 ? 2    DC  C C6    1 
ATOM   6999 P  P     . DT  C 3 3    ? 133.360 151.540 133.762 1.00 103.51 ? 3    DT  C P     1 
ATOM   7000 O  OP1   . DT  C 3 3    ? 133.412 153.016 133.720 1.00 102.16 ? 3    DT  C OP1   1 
ATOM   7001 O  OP2   . DT  C 3 3    ? 133.333 150.770 132.502 1.00 95.31  ? 3    DT  C OP2   1 
ATOM   7002 O  "O5'" . DT  C 3 3    ? 134.580 151.009 134.643 1.00 95.82  ? 3    DT  C "O5'" 1 
ATOM   7003 C  "C5'" . DT  C 3 3    ? 134.768 151.509 135.956 1.00 94.92  ? 3    DT  C "C5'" 1 
ATOM   7004 C  "C4'" . DT  C 3 3    ? 135.764 150.660 136.719 1.00 91.17  ? 3    DT  C "C4'" 1 
ATOM   7005 O  "O4'" . DT  C 3 3    ? 135.120 149.443 137.171 1.00 93.50  ? 3    DT  C "O4'" 1 
ATOM   7006 C  "C3'" . DT  C 3 3    ? 136.990 150.223 135.916 1.00 87.74  ? 3    DT  C "C3'" 1 
ATOM   7007 O  "O3'" . DT  C 3 3    ? 138.162 150.421 136.685 1.00 88.12  ? 3    DT  C "O3'" 1 
ATOM   7008 C  "C2'" . DT  C 3 3    ? 136.732 148.739 135.660 1.00 91.82  ? 3    DT  C "C2'" 1 
ATOM   7009 C  "C1'" . DT  C 3 3    ? 135.963 148.353 136.906 1.00 90.71  ? 3    DT  C "C1'" 1 
ATOM   7010 N  N1    . DT  C 3 3    ? 135.126 147.136 136.742 1.00 89.84  ? 3    DT  C N1    1 
ATOM   7011 C  C2    . DT  C 3 3    ? 134.994 146.276 137.799 1.00 93.21  ? 3    DT  C C2    1 
ATOM   7012 O  O2    . DT  C 3 3    ? 135.525 146.461 138.878 1.00 96.37  ? 3    DT  C O2    1 
ATOM   7013 N  N3    . DT  C 3 3    ? 134.210 145.183 137.554 1.00 96.28  ? 3    DT  C N3    1 
ATOM   7014 C  C4    . DT  C 3 3    ? 133.561 144.870 136.377 1.00 93.44  ? 3    DT  C C4    1 
ATOM   7015 O  O4    . DT  C 3 3    ? 132.877 143.860 136.256 1.00 95.52  ? 3    DT  C O4    1 
ATOM   7016 C  C5    . DT  C 3 3    ? 133.745 145.812 135.303 1.00 91.58  ? 3    DT  C C5    1 
ATOM   7017 C  C7    . DT  C 3 3    ? 133.089 145.576 133.977 1.00 94.27  ? 3    DT  C C7    1 
ATOM   7018 C  C6    . DT  C 3 3    ? 134.513 146.887 135.533 1.00 93.01  ? 3    DT  C C6    1 
ATOM   7019 P  P     . DT  C 3 4    ? 139.602 150.445 135.977 1.00 86.35  ? 4    DT  C P     1 
ATOM   7020 O  OP1   . DT  C 3 4    ? 140.200 151.776 136.209 1.00 81.29  ? 4    DT  C OP1   1 
ATOM   7021 O  OP2   . DT  C 3 4    ? 139.441 149.939 134.598 1.00 90.68  ? 4    DT  C OP2   1 
ATOM   7022 O  "O5'" . DT  C 3 4    ? 140.441 149.363 136.796 1.00 88.81  ? 4    DT  C "O5'" 1 
ATOM   7023 C  "C5'" . DT  C 3 4    ? 140.446 149.406 138.212 1.00 88.76  ? 4    DT  C "C5'" 1 
ATOM   7024 C  "C4'" . DT  C 3 4    ? 140.724 148.034 138.792 1.00 82.53  ? 4    DT  C "C4'" 1 
ATOM   7025 O  "O4'" . DT  C 3 4    ? 139.690 147.112 138.374 1.00 82.26  ? 4    DT  C "O4'" 1 
ATOM   7026 C  "C3'" . DT  C 3 4    ? 142.054 147.418 138.364 1.00 76.98  ? 4    DT  C "C3'" 1 
ATOM   7027 O  "O3'" . DT  C 3 4    ? 142.804 147.057 139.506 1.00 83.34  ? 4    DT  C "O3'" 1 
ATOM   7028 C  "C2'" . DT  C 3 4    ? 141.655 146.195 137.532 1.00 76.40  ? 4    DT  C "C2'" 1 
ATOM   7029 C  "C1'" . DT  C 3 4    ? 140.268 145.876 138.058 1.00 80.53  ? 4    DT  C "C1'" 1 
ATOM   7030 N  N1    . DT  C 3 4    ? 139.400 145.203 137.059 1.00 79.79  ? 4    DT  C N1    1 
ATOM   7031 C  C2    . DT  C 3 4    ? 138.753 144.042 137.400 1.00 83.86  ? 4    DT  C C2    1 
ATOM   7032 O  O2    . DT  C 3 4    ? 138.851 143.521 138.495 1.00 89.23  ? 4    DT  C O2    1 
ATOM   7033 N  N3    . DT  C 3 4    ? 137.978 143.505 136.408 1.00 81.80  ? 4    DT  C N3    1 
ATOM   7034 C  C4    . DT  C 3 4    ? 137.790 144.005 135.134 1.00 82.57  ? 4    DT  C C4    1 
ATOM   7035 O  O4    . DT  C 3 4    ? 137.073 143.450 134.310 1.00 82.62  ? 4    DT  C O4    1 
ATOM   7036 C  C5    . DT  C 3 4    ? 138.497 145.225 134.842 1.00 81.49  ? 4    DT  C C5    1 
ATOM   7037 C  C7    . DT  C 3 4    ? 138.372 145.862 133.491 1.00 81.42  ? 4    DT  C C7    1 
ATOM   7038 C  C6    . DT  C 3 4    ? 139.260 145.759 135.806 1.00 79.17  ? 4    DT  C C6    1 
ATOM   7039 P  P     . DC  C 3 5    ? 144.335 147.518 139.638 1.00 84.96  ? 5    DC  C P     1 
ATOM   7040 O  OP1   . DC  C 3 5    ? 144.736 147.368 141.052 1.00 80.02  ? 5    DC  C OP1   1 
ATOM   7041 O  OP2   . DC  C 3 5    ? 144.468 148.829 138.968 1.00 74.09  ? 5    DC  C OP2   1 
ATOM   7042 O  "O5'" . DC  C 3 5    ? 145.126 146.445 138.764 1.00 81.55  ? 5    DC  C "O5'" 1 
ATOM   7043 C  "C5'" . DC  C 3 5    ? 144.930 145.059 139.000 1.00 77.97  ? 5    DC  C "C5'" 1 
ATOM   7044 C  "C4'" . DC  C 3 5    ? 145.449 144.244 137.835 1.00 73.66  ? 5    DC  C "C4'" 1 
ATOM   7045 O  "O4'" . DC  C 3 5    ? 144.473 144.266 136.765 1.00 71.67  ? 5    DC  C "O4'" 1 
ATOM   7046 C  "C3'" . DC  C 3 5    ? 146.762 144.752 137.240 1.00 74.62  ? 5    DC  C "C3'" 1 
ATOM   7047 O  "O3'" . DC  C 3 5    ? 147.667 143.671 137.049 1.00 76.17  ? 5    DC  C "O3'" 1 
ATOM   7048 C  "C2'" . DC  C 3 5    ? 146.341 145.394 135.918 1.00 69.30  ? 5    DC  C "C2'" 1 
ATOM   7049 C  "C1'" . DC  C 3 5    ? 145.104 144.590 135.552 1.00 72.87  ? 5    DC  C "C1'" 1 
ATOM   7050 N  N1    . DC  C 3 5    ? 144.136 145.340 134.708 1.00 78.10  ? 5    DC  C N1    1 
ATOM   7051 C  C2    . DC  C 3 5    ? 143.054 144.668 134.133 1.00 76.73  ? 5    DC  C C2    1 
ATOM   7052 O  O2    . DC  C 3 5    ? 142.920 143.457 134.338 1.00 76.83  ? 5    DC  C O2    1 
ATOM   7053 N  N3    . DC  C 3 5    ? 142.181 145.364 133.369 1.00 75.36  ? 5    DC  C N3    1 
ATOM   7054 C  C4    . DC  C 3 5    ? 142.360 146.670 133.173 1.00 77.10  ? 5    DC  C C4    1 
ATOM   7055 N  N4    . DC  C 3 5    ? 141.473 147.315 132.410 1.00 79.29  ? 5    DC  C N4    1 
ATOM   7056 C  C5    . DC  C 3 5    ? 143.457 147.373 133.749 1.00 76.66  ? 5    DC  C C5    1 
ATOM   7057 C  C6    . DC  C 3 5    ? 144.311 146.676 134.502 1.00 77.05  ? 5    DC  C C6    1 
HETATM 7058 S  SG    . EIX C 3 6    ? 153.477 138.671 139.776 1.00 70.88  ? 6    EIX C SG    1 
HETATM 7059 C  "C1'" . EIX C 3 6    ? 153.224 141.090 138.182 1.00 69.25  ? 6    EIX C "C1'" 1 
HETATM 7060 C  C2    . EIX C 3 6    ? 154.970 142.167 139.483 1.00 66.27  ? 6    EIX C C2    1 
HETATM 7061 C  "C2'" . EIX C 3 6    ? 153.711 140.679 136.806 1.00 59.81  ? 6    EIX C "C2'" 1 
HETATM 7062 C  "C3'" . EIX C 3 6    ? 152.563 141.184 135.963 1.00 59.72  ? 6    EIX C "C3'" 1 
HETATM 7063 C  C4    . EIX C 3 6    ? 155.471 141.152 141.427 1.00 61.94  ? 6    EIX C C4    1 
HETATM 7064 C  "C4'" . EIX C 3 6    ? 152.034 142.405 136.696 1.00 60.12  ? 6    EIX C "C4'" 1 
HETATM 7065 C  C5    . EIX C 3 6    ? 155.727 139.848 140.719 1.00 63.33  ? 6    EIX C C5    1 
HETATM 7066 C  "C5'" . EIX C 3 6    ? 150.527 142.272 136.843 1.00 61.44  ? 6    EIX C "C5'" 1 
HETATM 7067 C  C6    . EIX C 3 6    ? 154.873 139.745 139.463 1.00 58.18  ? 6    EIX C C6    1 
HETATM 7068 C  CM5   . EIX C 3 6    ? 157.206 139.746 140.372 1.00 63.84  ? 6    EIX C CM5   1 
HETATM 7069 F  F     . EIX C 3 6    ? 155.423 138.854 141.526 1.00 68.11  ? 6    EIX C F     1 
HETATM 7070 N  N1    . EIX C 3 6    ? 154.383 141.054 139.059 1.00 65.44  ? 6    EIX C N1    1 
HETATM 7071 N  N3    . EIX C 3 6    ? 155.393 142.203 140.742 1.00 61.25  ? 6    EIX C N3    1 
HETATM 7072 N  N4    . EIX C 3 6    ? 155.340 141.194 142.748 1.00 63.32  ? 6    EIX C N4    1 
HETATM 7073 O  O2    . EIX C 3 6    ? 155.121 143.127 138.747 1.00 66.31  ? 6    EIX C O2    1 
HETATM 7074 O  "O3'" . EIX C 3 6    ? 152.961 141.459 134.634 1.00 66.21  ? 6    EIX C "O3'" 1 
HETATM 7075 O  "O4'" . EIX C 3 6    ? 152.660 142.388 137.981 1.00 58.97  ? 6    EIX C "O4'" 1 
HETATM 7076 O  "O5'" . EIX C 3 6    ? 150.045 143.185 137.820 1.00 60.90  ? 6    EIX C "O5'" 1 
HETATM 7077 O  OP2   . EIX C 3 6    ? 148.272 144.046 139.577 1.00 69.42  ? 6    EIX C OP2   1 
HETATM 7078 P  P     . EIX C 3 6    ? 148.512 143.107 138.294 1.00 73.61  ? 6    EIX C P     1 
HETATM 7079 O  OP1   . EIX C 3 6    ? 148.110 141.709 138.547 1.00 60.46  ? 6    EIX C OP1   1 
ATOM   7080 P  P     . DG  C 3 7    ? 152.832 140.319 133.510 1.00 91.22  ? 7    DG  C P     1 
ATOM   7081 O  OP1   . DG  C 3 7    ? 153.723 139.207 133.896 1.00 83.83  ? 7    DG  C OP1   1 
ATOM   7082 O  OP2   . DG  C 3 7    ? 153.005 140.974 132.198 1.00 90.08  ? 7    DG  C OP2   1 
ATOM   7083 O  "O5'" . DG  C 3 7    ? 151.316 139.821 133.623 1.00 71.78  ? 7    DG  C "O5'" 1 
ATOM   7084 C  "C5'" . DG  C 3 7    ? 151.009 138.607 134.302 1.00 74.57  ? 7    DG  C "C5'" 1 
ATOM   7085 C  "C4'" . DG  C 3 7    ? 150.310 137.631 133.378 1.00 77.15  ? 7    DG  C "C4'" 1 
ATOM   7086 O  "O4'" . DG  C 3 7    ? 149.347 138.338 132.586 1.00 78.32  ? 7    DG  C "O4'" 1 
ATOM   7087 C  "C3'" . DG  C 3 7    ? 151.222 136.923 132.383 1.00 77.69  ? 7    DG  C "C3'" 1 
ATOM   7088 O  "O3'" . DG  C 3 7    ? 151.468 135.599 132.829 1.00 78.65  ? 7    DG  C "O3'" 1 
ATOM   7089 C  "C2'" . DG  C 3 7    ? 150.446 136.944 131.052 1.00 82.45  ? 7    DG  C "C2'" 1 
ATOM   7090 C  "C1'" . DG  C 3 7    ? 149.129 137.633 131.396 1.00 82.54  ? 7    DG  C "C1'" 1 
ATOM   7091 N  N9    . DG  C 3 7    ? 148.681 138.594 130.395 1.00 80.72  ? 7    DG  C N9    1 
ATOM   7092 C  C8    . DG  C 3 7    ? 149.308 139.759 130.035 1.00 79.77  ? 7    DG  C C8    1 
ATOM   7093 N  N7    . DG  C 3 7    ? 148.659 140.441 129.135 1.00 75.29  ? 7    DG  C N7    1 
ATOM   7094 C  C5    . DG  C 3 7    ? 147.527 139.683 128.885 1.00 72.54  ? 7    DG  C C5    1 
ATOM   7095 C  C6    . DG  C 3 7    ? 146.454 139.917 127.999 1.00 81.32  ? 7    DG  C C6    1 
ATOM   7096 O  O6    . DG  C 3 7    ? 146.287 140.874 127.235 1.00 90.13  ? 7    DG  C O6    1 
ATOM   7097 N  N1    . DG  C 3 7    ? 145.510 138.902 128.053 1.00 83.01  ? 7    DG  C N1    1 
ATOM   7098 C  C2    . DG  C 3 7    ? 145.592 137.799 128.861 1.00 81.74  ? 7    DG  C C2    1 
ATOM   7099 N  N2    . DG  C 3 7    ? 144.584 136.925 128.773 1.00 83.18  ? 7    DG  C N2    1 
ATOM   7100 N  N3    . DG  C 3 7    ? 146.594 137.564 129.694 1.00 81.25  ? 7    DG  C N3    1 
ATOM   7101 C  C4    . DG  C 3 7    ? 147.521 138.546 129.656 1.00 76.09  ? 7    DG  C C4    1 
ATOM   7102 P  P     . DT  C 3 8    ? 152.276 134.559 131.913 1.00 96.24  ? 8    DT  C P     1 
ATOM   7103 O  OP1   . DT  C 3 8    ? 152.937 133.598 132.818 1.00 92.05  ? 8    DT  C OP1   1 
ATOM   7104 O  OP2   . DT  C 3 8    ? 153.093 135.318 130.943 1.00 95.12  ? 8    DT  C OP2   1 
ATOM   7105 O  "O5'" . DT  C 3 8    ? 151.126 133.791 131.118 1.00 94.32  ? 8    DT  C "O5'" 1 
ATOM   7106 C  "C5'" . DT  C 3 8    ? 150.044 133.214 131.832 1.00 90.99  ? 8    DT  C "C5'" 1 
ATOM   7107 C  "C4'" . DT  C 3 8    ? 149.160 132.388 130.915 1.00 94.36  ? 8    DT  C "C4'" 1 
ATOM   7108 O  "O4'" . DT  C 3 8    ? 148.375 133.268 130.070 1.00 92.07  ? 8    DT  C "O4'" 1 
ATOM   7109 C  "C3'" . DT  C 3 8    ? 149.905 131.452 129.972 1.00 91.66  ? 8    DT  C "C3'" 1 
ATOM   7110 O  "O3'" . DT  C 3 8    ? 149.160 130.264 129.782 1.00 88.03  ? 8    DT  C "O3'" 1 
ATOM   7111 C  "C2'" . DT  C 3 8    ? 149.989 132.266 128.688 1.00 95.25  ? 8    DT  C "C2'" 1 
ATOM   7112 C  "C1'" . DT  C 3 8    ? 148.664 133.018 128.711 1.00 95.60  ? 8    DT  C "C1'" 1 
ATOM   7113 N  N1    . DT  C 3 8    ? 148.711 134.323 127.996 1.00 89.88  ? 8    DT  C N1    1 
ATOM   7114 C  C2    . DT  C 3 8    ? 147.625 134.722 127.256 1.00 91.35  ? 8    DT  C C2    1 
ATOM   7115 O  O2    . DT  C 3 8    ? 146.612 134.058 127.150 1.00 96.48  ? 8    DT  C O2    1 
ATOM   7116 N  N3    . DT  C 3 8    ? 147.767 135.937 126.640 1.00 91.88  ? 8    DT  C N3    1 
ATOM   7117 C  C4    . DT  C 3 8    ? 148.867 136.772 126.694 1.00 92.56  ? 8    DT  C C4    1 
ATOM   7118 O  O4    . DT  C 3 8    ? 148.903 137.846 126.108 1.00 95.66  ? 8    DT  C O4    1 
ATOM   7119 C  C5    . DT  C 3 8    ? 149.971 136.291 127.487 1.00 88.19  ? 8    DT  C C5    1 
ATOM   7120 C  C7    . DT  C 3 8    ? 151.218 137.112 127.615 1.00 88.38  ? 8    DT  C C7    1 
ATOM   7121 C  C6    . DT  C 3 8    ? 149.842 135.104 128.092 1.00 89.03  ? 8    DT  C C6    1 
ATOM   7122 P  P     . DA  C 3 9    ? 149.857 128.836 130.004 1.00 108.07 ? 9    DA  C P     1 
ATOM   7123 O  OP1   . DA  C 3 9    ? 149.616 128.427 131.403 1.00 106.88 ? 9    DA  C OP1   1 
ATOM   7124 O  OP2   . DA  C 3 9    ? 151.237 128.934 129.487 1.00 106.70 ? 9    DA  C OP2   1 
ATOM   7125 O  "O5'" . DA  C 3 9    ? 149.049 127.859 129.035 1.00 102.96 ? 9    DA  C "O5'" 1 
ATOM   7126 C  "C5'" . DA  C 3 9    ? 149.225 127.952 127.632 1.00 102.74 ? 9    DA  C "C5'" 1 
ATOM   7127 C  "C4'" . DA  C 3 9    ? 147.889 127.911 126.918 1.00 103.31 ? 9    DA  C "C4'" 1 
ATOM   7128 O  "O4'" . DA  C 3 9    ? 147.501 129.252 126.555 1.00 100.67 ? 9    DA  C "O4'" 1 
ATOM   7129 C  "C3'" . DA  C 3 9    ? 147.889 127.140 125.615 1.00 105.43 ? 9    DA  C "C3'" 1 
ATOM   7130 O  "O3'" . DA  C 3 9    ? 146.583 126.686 125.320 1.00 104.89 ? 9    DA  C "O3'" 1 
ATOM   7131 C  "C2'" . DA  C 3 9    ? 148.357 128.187 124.613 1.00 103.03 ? 9    DA  C "C2'" 1 
ATOM   7132 C  "C1'" . DA  C 3 9    ? 147.786 129.484 125.189 1.00 100.05 ? 9    DA  C "C1'" 1 
ATOM   7133 N  N9    . DA  C 3 9    ? 148.713 130.605 125.100 1.00 100.06 ? 9    DA  C N9    1 
ATOM   7134 C  C8    . DA  C 3 9    ? 149.945 130.698 125.679 1.00 103.39 ? 9    DA  C C8    1 
ATOM   7135 N  N7    . DA  C 3 9    ? 150.566 131.824 125.424 1.00 103.03 ? 9    DA  C N7    1 
ATOM   7136 C  C5    . DA  C 3 9    ? 149.681 132.514 124.617 1.00 100.57 ? 9    DA  C C5    1 
ATOM   7137 C  C6    . DA  C 3 9    ? 149.748 133.777 124.005 1.00 100.92 ? 9    DA  C C6    1 
ATOM   7138 N  N6    . DA  C 3 9    ? 150.795 134.596 124.125 1.00 102.91 ? 9    DA  C N6    1 
ATOM   7139 N  N1    . DA  C 3 9    ? 148.693 134.168 123.263 1.00 101.99 ? 9    DA  C N1    1 
ATOM   7140 C  C2    . DA  C 3 9    ? 147.647 133.345 123.146 1.00 102.16 ? 9    DA  C C2    1 
ATOM   7141 N  N3    . DA  C 3 9    ? 147.470 132.136 123.674 1.00 103.15 ? 9    DA  C N3    1 
ATOM   7142 C  C4    . DA  C 3 9    ? 148.535 131.777 124.405 1.00 102.13 ? 9    DA  C C4    1 
ATOM   7143 P  P     . DA  C 3 10   ? 146.369 125.505 124.255 1.00 123.77 ? 10   DA  C P     1 
ATOM   7144 O  OP1   . DA  C 3 10   ? 145.037 124.913 124.505 1.00 122.53 ? 10   DA  C OP1   1 
ATOM   7145 O  OP2   . DA  C 3 10   ? 147.576 124.652 124.286 1.00 121.37 ? 10   DA  C OP2   1 
ATOM   7146 O  "O5'" . DA  C 3 10   ? 146.341 126.264 122.849 1.00 123.31 ? 10   DA  C "O5'" 1 
ATOM   7147 C  "C5'" . DA  C 3 10   ? 145.312 127.201 122.577 1.00 123.49 ? 10   DA  C "C5'" 1 
ATOM   7148 C  "C4'" . DA  C 3 10   ? 145.622 127.997 121.323 1.00 121.47 ? 10   DA  C "C4'" 1 
ATOM   7149 O  "O4'" . DA  C 3 10   ? 146.603 129.006 121.619 1.00 118.96 ? 10   DA  C "O4'" 1 
ATOM   7150 C  "C3'" . DA  C 3 10   ? 146.198 127.181 120.165 1.00 120.96 ? 10   DA  C "C3'" 1 
ATOM   7151 O  "O3'" . DA  C 3 10   ? 145.233 127.070 119.128 1.00 122.09 ? 10   DA  C "O3'" 1 
ATOM   7152 C  "C2'" . DA  C 3 10   ? 147.438 127.974 119.709 1.00 120.06 ? 10   DA  C "C2'" 1 
ATOM   7153 C  "C1'" . DA  C 3 10   ? 147.290 129.302 120.439 1.00 118.98 ? 10   DA  C "C1'" 1 
ATOM   7154 N  N9    . DA  C 3 10   ? 148.565 129.914 120.791 1.00 120.53 ? 10   DA  C N9    1 
ATOM   7155 C  C8    . DA  C 3 10   ? 149.533 129.389 121.596 1.00 122.63 ? 10   DA  C C8    1 
ATOM   7156 N  N7    . DA  C 3 10   ? 150.579 130.166 121.741 1.00 123.20 ? 10   DA  C N7    1 
ATOM   7157 C  C5    . DA  C 3 10   ? 150.274 131.279 120.979 1.00 120.95 ? 10   DA  C C5    1 
ATOM   7158 C  C6    . DA  C 3 10   ? 150.976 132.468 120.719 1.00 120.28 ? 10   DA  C C6    1 
ATOM   7159 N  N6    . DA  C 3 10   ? 152.183 132.731 121.225 1.00 119.44 ? 10   DA  C N6    1 
ATOM   7160 N  N1    . DA  C 3 10   ? 150.390 133.378 119.913 1.00 121.98 ? 10   DA  C N1    1 
ATOM   7161 C  C2    . DA  C 3 10   ? 149.181 133.108 119.410 1.00 121.61 ? 10   DA  C C2    1 
ATOM   7162 N  N3    . DA  C 3 10   ? 148.425 132.026 119.584 1.00 119.90 ? 10   DA  C N3    1 
ATOM   7163 C  C4    . DA  C 3 10   ? 149.035 131.142 120.387 1.00 120.61 ? 10   DA  C C4    1 
ATOM   7164 P  P     . DG  C 3 11   ? 145.600 126.341 117.744 1.00 146.57 ? 11   DG  C P     1 
ATOM   7165 O  OP1   . DG  C 3 11   ? 144.334 125.855 117.154 1.00 144.34 ? 11   DG  C OP1   1 
ATOM   7166 O  OP2   . DG  C 3 11   ? 146.704 125.390 118.000 1.00 142.88 ? 11   DG  C OP2   1 
ATOM   7167 O  "O5'" . DG  C 3 11   ? 146.164 127.525 116.832 1.00 144.14 ? 11   DG  C "O5'" 1 
ATOM   7168 C  "C5'" . DG  C 3 11   ? 145.415 128.722 116.699 1.00 142.52 ? 11   DG  C "C5'" 1 
ATOM   7169 C  "C4'" . DG  C 3 11   ? 146.252 129.818 116.072 1.00 142.46 ? 11   DG  C "C4'" 1 
ATOM   7170 O  "O4'" . DG  C 3 11   ? 147.360 130.150 116.944 1.00 144.36 ? 11   DG  C "O4'" 1 
ATOM   7171 C  "C3'" . DG  C 3 11   ? 146.873 129.463 114.714 1.00 143.82 ? 11   DG  C "C3'" 1 
ATOM   7172 O  "O3'" . DG  C 3 11   ? 146.448 130.391 113.725 1.00 146.30 ? 11   DG  C "O3'" 1 
ATOM   7173 C  "C2'" . DG  C 3 11   ? 148.382 129.557 114.958 1.00 143.32 ? 11   DG  C "C2'" 1 
ATOM   7174 C  "C1'" . DG  C 3 11   ? 148.448 130.506 116.139 1.00 143.71 ? 11   DG  C "C1'" 1 
ATOM   7175 N  N9    . DG  C 3 11   ? 149.682 130.392 116.911 1.00 143.01 ? 11   DG  C N9    1 
ATOM   7176 C  C8    . DG  C 3 11   ? 150.072 129.344 117.708 1.00 141.45 ? 11   DG  C C8    1 
ATOM   7177 N  N7    . DG  C 3 11   ? 151.238 129.523 118.264 1.00 141.23 ? 11   DG  C N7    1 
ATOM   7178 C  C5    . DG  C 3 11   ? 151.649 130.765 117.800 1.00 143.30 ? 11   DG  C C5    1 
ATOM   7179 C  C6    . DG  C 3 11   ? 152.836 131.490 118.060 1.00 143.50 ? 11   DG  C C6    1 
ATOM   7180 O  O6    . DG  C 3 11   ? 153.793 131.166 118.777 1.00 141.91 ? 11   DG  C O6    1 
ATOM   7181 N  N1    . DG  C 3 11   ? 152.851 132.710 117.389 1.00 143.35 ? 11   DG  C N1    1 
ATOM   7182 C  C2    . DG  C 3 11   ? 151.847 133.171 116.572 1.00 142.37 ? 11   DG  C C2    1 
ATOM   7183 N  N2    . DG  C 3 11   ? 152.037 134.372 116.007 1.00 142.36 ? 11   DG  C N2    1 
ATOM   7184 N  N3    . DG  C 3 11   ? 150.732 132.500 116.320 1.00 141.50 ? 11   DG  C N3    1 
ATOM   7185 C  C4    . DG  C 3 11   ? 150.702 131.311 116.965 1.00 143.20 ? 11   DG  C C4    1 
ATOM   7186 P  P     . DT  C 3 12   ? 146.815 130.150 112.179 1.00 151.71 ? 12   DT  C P     1 
ATOM   7187 O  OP1   . DT  C 3 12   ? 145.856 130.930 111.366 1.00 146.90 ? 12   DT  C OP1   1 
ATOM   7188 O  OP2   . DT  C 3 12   ? 146.940 128.690 111.971 1.00 147.47 ? 12   DT  C OP2   1 
ATOM   7189 O  "O5'" . DT  C 3 12   ? 148.271 130.795 112.021 1.00 149.18 ? 12   DT  C "O5'" 1 
ATOM   7190 C  "C5'" . DT  C 3 12   ? 148.481 132.161 112.357 1.00 148.05 ? 12   DT  C "C5'" 1 
ATOM   7191 C  "C4'" . DT  C 3 12   ? 149.951 132.531 112.246 1.00 146.96 ? 12   DT  C "C4'" 1 
ATOM   7192 O  "O4'" . DT  C 3 12   ? 150.698 131.904 113.318 1.00 146.76 ? 12   DT  C "O4'" 1 
ATOM   7193 C  "C3'" . DT  C 3 12   ? 150.632 132.105 110.940 1.00 147.86 ? 12   DT  C "C3'" 1 
ATOM   7194 O  "O3'" . DT  C 3 12   ? 151.226 133.233 110.312 1.00 147.80 ? 12   DT  C "O3'" 1 
ATOM   7195 C  "C2'" . DT  C 3 12   ? 151.690 131.088 111.385 1.00 147.09 ? 12   DT  C "C2'" 1 
ATOM   7196 C  "C1'" . DT  C 3 12   ? 151.949 131.511 112.821 1.00 147.46 ? 12   DT  C "C1'" 1 
ATOM   7197 N  N1    . DT  C 3 12   ? 152.480 130.415 113.679 1.00 148.33 ? 12   DT  C N1    1 
ATOM   7198 C  C2    . DT  C 3 12   ? 153.735 130.539 114.228 1.00 148.54 ? 12   DT  C C2    1 
ATOM   7199 O  O2    . DT  C 3 12   ? 154.447 131.510 114.051 1.00 148.49 ? 12   DT  C O2    1 
ATOM   7200 N  N3    . DT  C 3 12   ? 154.129 129.479 114.999 1.00 147.51 ? 12   DT  C N3    1 
ATOM   7201 C  C4    . DT  C 3 12   ? 153.410 128.330 115.269 1.00 147.67 ? 12   DT  C C4    1 
ATOM   7202 O  O4    . DT  C 3 12   ? 153.852 127.431 115.976 1.00 147.07 ? 12   DT  C O4    1 
ATOM   7203 C  C5    . DT  C 3 12   ? 152.103 128.263 114.662 1.00 148.45 ? 12   DT  C C5    1 
ATOM   7204 C  C7    . DT  C 3 12   ? 151.229 127.065 114.883 1.00 148.32 ? 12   DT  C C7    1 
ATOM   7205 C  C6    . DT  C 3 12   ? 151.707 129.297 113.904 1.00 148.19 ? 12   DT  C C6    1 
HETATM 7206 N  N     . SAH D 4 .    ? 162.503 130.356 141.544 0.67 88.07  ? 1701 SAH A N     1 
HETATM 7207 C  CA    . SAH D 4 .    ? 163.490 130.687 140.530 0.67 88.82  ? 1701 SAH A CA    1 
HETATM 7208 C  CB    . SAH D 4 .    ? 162.963 131.777 139.629 0.67 87.28  ? 1701 SAH A CB    1 
HETATM 7209 C  CG    . SAH D 4 .    ? 162.288 131.247 138.379 0.67 89.16  ? 1701 SAH A CG    1 
HETATM 7210 S  SD    . SAH D 4 .    ? 160.549 130.812 138.613 0.67 88.18  ? 1701 SAH A SD    1 
HETATM 7211 C  C     . SAH D 4 .    ? 164.807 131.117 141.145 0.67 90.76  ? 1701 SAH A C     1 
HETATM 7212 O  O     . SAH D 4 .    ? 165.319 132.210 140.915 0.67 90.64  ? 1701 SAH A O     1 
HETATM 7213 O  OXT   . SAH D 4 .    ? 165.409 130.372 141.904 0.67 89.54  ? 1701 SAH A OXT   1 
HETATM 7214 C  "C5'" . SAH D 4 .    ? 160.165 132.104 137.411 0.67 87.97  ? 1701 SAH A "C5'" 1 
HETATM 7215 C  "C4'" . SAH D 4 .    ? 160.993 131.930 136.142 0.67 91.34  ? 1701 SAH A "C4'" 1 
HETATM 7216 O  "O4'" . SAH D 4 .    ? 160.760 130.672 135.543 0.67 93.27  ? 1701 SAH A "O4'" 1 
HETATM 7217 C  "C3'" . SAH D 4 .    ? 160.664 132.945 135.063 0.67 91.20  ? 1701 SAH A "C3'" 1 
HETATM 7218 O  "O3'" . SAH D 4 .    ? 161.568 134.020 135.116 0.67 90.76  ? 1701 SAH A "O3'" 1 
HETATM 7219 C  "C2'" . SAH D 4 .    ? 160.858 132.176 133.772 0.67 90.01  ? 1701 SAH A "C2'" 1 
HETATM 7220 O  "O2'" . SAH D 4 .    ? 161.931 132.724 133.046 0.67 89.15  ? 1701 SAH A "O2'" 1 
HETATM 7221 C  "C1'" . SAH D 4 .    ? 161.189 130.752 134.203 0.67 90.67  ? 1701 SAH A "C1'" 1 
HETATM 7222 N  N9    . SAH D 4 .    ? 160.463 129.782 133.372 0.67 90.77  ? 1701 SAH A N9    1 
HETATM 7223 C  C8    . SAH D 4 .    ? 159.841 130.085 132.196 0.67 89.62  ? 1701 SAH A C8    1 
HETATM 7224 N  N7    . SAH D 4 .    ? 159.296 128.952 131.710 0.67 91.75  ? 1701 SAH A N7    1 
HETATM 7225 C  C5    . SAH D 4 .    ? 159.554 127.932 132.558 0.67 93.44  ? 1701 SAH A C5    1 
HETATM 7226 C  C6    . SAH D 4 .    ? 159.218 126.581 132.525 0.67 92.80  ? 1701 SAH A C6    1 
HETATM 7227 N  N6    . SAH D 4 .    ? 158.506 126.080 131.511 0.67 92.75  ? 1701 SAH A N6    1 
HETATM 7228 N  N1    . SAH D 4 .    ? 159.639 125.769 133.558 0.67 89.23  ? 1701 SAH A N1    1 
HETATM 7229 C  C2    . SAH D 4 .    ? 160.379 126.295 134.599 0.67 88.26  ? 1701 SAH A C2    1 
HETATM 7230 N  N3    . SAH D 4 .    ? 160.695 127.635 134.626 0.67 89.69  ? 1701 SAH A N3    1 
HETATM 7231 C  C4    . SAH D 4 .    ? 160.296 128.441 133.615 0.67 91.95  ? 1701 SAH A C4    1 
HETATM 7232 ZN ZN    . ZN  E 5 .    ? 133.315 135.034 116.618 1.00 155.19 ? 1702 ZN  A ZN    1 
HETATM 7233 ZN ZN    . ZN  F 5 .    ? 140.682 144.210 182.118 1.00 162.40 ? 1703 ZN  A ZN    1 
# 
