data_8XQ1
# 
_entry.id   8XQ1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XQ1         pdb_00008xq1 10.2210/pdb8xq1/pdb 
WWPDB D_1300043638 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XQ1 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bilee@ncc.re.kr 
_pdbx_contact_author.name_first         'Byung Il' 
_pdbx_contact_author.name_last          Lee 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1270-8439 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bong, S.M.' 1 ?                   
'Lee, B.I.'  2 0000-0003-1270-8439 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of spleen tyrosine kinase(SYK) in complex with SKI-G-1673' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Lee, B.I.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Tyrosine-protein kinase SYK' 33900.965 2   2.7.10.2 ? 'PROTEIN KINASE DOMAIN, RESIDUES 356-635' ? 
2 non-polymer syn 
;cyclopropyl-[5-[[4-[4-[[(3~{R},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-pyrrolo[2,3-b]pyridin-3-yl]methanone
;
502.568   2   ?        ? ?                                         ? 
3 water       nat water 18.015    295 ?        ? ?                                         ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Spleen tyrosine kinase,p72-Syk' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM
IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL
SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA
GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM
IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL
SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA
GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;cyclopropyl-[5-[[4-[4-[[(3~{R},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-pyrrolo[2,3-b]pyridin-3-yl]methanone
;
A1LV6 
3 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLU n 
1 2   GLU n 
1 3   ILE n 
1 4   ARG n 
1 5   PRO n 
1 6   LYS n 
1 7   GLU n 
1 8   VAL n 
1 9   TYR n 
1 10  LEU n 
1 11  ASP n 
1 12  ARG n 
1 13  LYS n 
1 14  LEU n 
1 15  LEU n 
1 16  THR n 
1 17  LEU n 
1 18  GLU n 
1 19  ASP n 
1 20  LYS n 
1 21  GLU n 
1 22  LEU n 
1 23  GLY n 
1 24  SER n 
1 25  GLY n 
1 26  ASN n 
1 27  PHE n 
1 28  GLY n 
1 29  THR n 
1 30  VAL n 
1 31  LYS n 
1 32  LYS n 
1 33  GLY n 
1 34  TYR n 
1 35  TYR n 
1 36  GLN n 
1 37  MET n 
1 38  LYS n 
1 39  LYS n 
1 40  VAL n 
1 41  VAL n 
1 42  LYS n 
1 43  THR n 
1 44  VAL n 
1 45  ALA n 
1 46  VAL n 
1 47  LYS n 
1 48  ILE n 
1 49  LEU n 
1 50  LYS n 
1 51  ASN n 
1 52  GLU n 
1 53  ALA n 
1 54  ASN n 
1 55  ASP n 
1 56  PRO n 
1 57  ALA n 
1 58  LEU n 
1 59  LYS n 
1 60  ASP n 
1 61  GLU n 
1 62  LEU n 
1 63  LEU n 
1 64  ALA n 
1 65  GLU n 
1 66  ALA n 
1 67  ASN n 
1 68  VAL n 
1 69  MET n 
1 70  GLN n 
1 71  GLN n 
1 72  LEU n 
1 73  ASP n 
1 74  ASN n 
1 75  PRO n 
1 76  TYR n 
1 77  ILE n 
1 78  VAL n 
1 79  ARG n 
1 80  MET n 
1 81  ILE n 
1 82  GLY n 
1 83  ILE n 
1 84  CYS n 
1 85  GLU n 
1 86  ALA n 
1 87  GLU n 
1 88  SER n 
1 89  TRP n 
1 90  MET n 
1 91  LEU n 
1 92  VAL n 
1 93  MET n 
1 94  GLU n 
1 95  MET n 
1 96  ALA n 
1 97  GLU n 
1 98  LEU n 
1 99  GLY n 
1 100 PRO n 
1 101 LEU n 
1 102 ASN n 
1 103 LYS n 
1 104 TYR n 
1 105 LEU n 
1 106 GLN n 
1 107 GLN n 
1 108 ASN n 
1 109 ARG n 
1 110 HIS n 
1 111 VAL n 
1 112 LYS n 
1 113 ASP n 
1 114 LYS n 
1 115 ASN n 
1 116 ILE n 
1 117 ILE n 
1 118 GLU n 
1 119 LEU n 
1 120 VAL n 
1 121 HIS n 
1 122 GLN n 
1 123 VAL n 
1 124 SER n 
1 125 MET n 
1 126 GLY n 
1 127 MET n 
1 128 LYS n 
1 129 TYR n 
1 130 LEU n 
1 131 GLU n 
1 132 GLU n 
1 133 SER n 
1 134 ASN n 
1 135 PHE n 
1 136 VAL n 
1 137 HIS n 
1 138 ARG n 
1 139 ASP n 
1 140 LEU n 
1 141 ALA n 
1 142 ALA n 
1 143 ARG n 
1 144 ASN n 
1 145 VAL n 
1 146 LEU n 
1 147 LEU n 
1 148 VAL n 
1 149 THR n 
1 150 GLN n 
1 151 HIS n 
1 152 TYR n 
1 153 ALA n 
1 154 LYS n 
1 155 ILE n 
1 156 SER n 
1 157 ASP n 
1 158 PHE n 
1 159 GLY n 
1 160 LEU n 
1 161 SER n 
1 162 LYS n 
1 163 ALA n 
1 164 LEU n 
1 165 ARG n 
1 166 ALA n 
1 167 ASP n 
1 168 GLU n 
1 169 ASN n 
1 170 TYR n 
1 171 TYR n 
1 172 LYS n 
1 173 ALA n 
1 174 GLN n 
1 175 THR n 
1 176 HIS n 
1 177 GLY n 
1 178 LYS n 
1 179 TRP n 
1 180 PRO n 
1 181 VAL n 
1 182 LYS n 
1 183 TRP n 
1 184 TYR n 
1 185 ALA n 
1 186 PRO n 
1 187 GLU n 
1 188 CYS n 
1 189 ILE n 
1 190 ASN n 
1 191 TYR n 
1 192 TYR n 
1 193 LYS n 
1 194 PHE n 
1 195 SER n 
1 196 SER n 
1 197 LYS n 
1 198 SER n 
1 199 ASP n 
1 200 VAL n 
1 201 TRP n 
1 202 SER n 
1 203 PHE n 
1 204 GLY n 
1 205 VAL n 
1 206 LEU n 
1 207 MET n 
1 208 TRP n 
1 209 GLU n 
1 210 ALA n 
1 211 PHE n 
1 212 SER n 
1 213 TYR n 
1 214 GLY n 
1 215 GLN n 
1 216 LYS n 
1 217 PRO n 
1 218 TYR n 
1 219 ARG n 
1 220 GLY n 
1 221 MET n 
1 222 LYS n 
1 223 GLY n 
1 224 SER n 
1 225 GLU n 
1 226 VAL n 
1 227 THR n 
1 228 ALA n 
1 229 MET n 
1 230 LEU n 
1 231 GLU n 
1 232 LYS n 
1 233 GLY n 
1 234 GLU n 
1 235 ARG n 
1 236 MET n 
1 237 GLY n 
1 238 CYS n 
1 239 PRO n 
1 240 ALA n 
1 241 GLY n 
1 242 CYS n 
1 243 PRO n 
1 244 ARG n 
1 245 GLU n 
1 246 MET n 
1 247 TYR n 
1 248 ASP n 
1 249 LEU n 
1 250 MET n 
1 251 ASN n 
1 252 LEU n 
1 253 CYS n 
1 254 TRP n 
1 255 THR n 
1 256 TYR n 
1 257 ASP n 
1 258 VAL n 
1 259 GLU n 
1 260 ASN n 
1 261 ARG n 
1 262 PRO n 
1 263 GLY n 
1 264 PHE n 
1 265 ALA n 
1 266 ALA n 
1 267 VAL n 
1 268 GLU n 
1 269 LEU n 
1 270 ARG n 
1 271 LEU n 
1 272 ARG n 
1 273 ASN n 
1 274 TYR n 
1 275 TYR n 
1 276 TYR n 
1 277 ASP n 
1 278 VAL n 
1 279 VAL n 
1 280 ASN n 
1 281 LEU n 
1 282 GLU n 
1 283 HIS n 
1 284 HIS n 
1 285 HIS n 
1 286 HIS n 
1 287 HIS n 
1 288 HIS n 
1 289 HIS n 
1 290 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   290 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SYK 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LV6 non-polymer         . 
;cyclopropyl-[5-[[4-[4-[[(3~{R},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-pyrrolo[2,3-b]pyridin-3-yl]methanone
;
? 'C26 H30 N8 O3'  502.568 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLU 1   356 ?   ?   ?   A . n 
A 1 2   GLU 2   357 ?   ?   ?   A . n 
A 1 3   ILE 3   358 ?   ?   ?   A . n 
A 1 4   ARG 4   359 ?   ?   ?   A . n 
A 1 5   PRO 5   360 ?   ?   ?   A . n 
A 1 6   LYS 6   361 ?   ?   ?   A . n 
A 1 7   GLU 7   362 ?   ?   ?   A . n 
A 1 8   VAL 8   363 ?   ?   ?   A . n 
A 1 9   TYR 9   364 364 TYR TYR A . n 
A 1 10  LEU 10  365 365 LEU LEU A . n 
A 1 11  ASP 11  366 366 ASP ASP A . n 
A 1 12  ARG 12  367 367 ARG ARG A . n 
A 1 13  LYS 13  368 368 LYS LYS A . n 
A 1 14  LEU 14  369 369 LEU LEU A . n 
A 1 15  LEU 15  370 370 LEU LEU A . n 
A 1 16  THR 16  371 371 THR THR A . n 
A 1 17  LEU 17  372 372 LEU LEU A . n 
A 1 18  GLU 18  373 373 GLU GLU A . n 
A 1 19  ASP 19  374 374 ASP ASP A . n 
A 1 20  LYS 20  375 375 LYS LYS A . n 
A 1 21  GLU 21  376 376 GLU GLU A . n 
A 1 22  LEU 22  377 377 LEU LEU A . n 
A 1 23  GLY 23  378 378 GLY GLY A . n 
A 1 24  SER 24  379 379 SER SER A . n 
A 1 25  GLY 25  380 380 GLY GLY A . n 
A 1 26  ASN 26  381 381 ASN ASN A . n 
A 1 27  PHE 27  382 382 PHE PHE A . n 
A 1 28  GLY 28  383 383 GLY GLY A . n 
A 1 29  THR 29  384 384 THR THR A . n 
A 1 30  VAL 30  385 385 VAL VAL A . n 
A 1 31  LYS 31  386 386 LYS LYS A . n 
A 1 32  LYS 32  387 387 LYS LYS A . n 
A 1 33  GLY 33  388 388 GLY GLY A . n 
A 1 34  TYR 34  389 389 TYR TYR A . n 
A 1 35  TYR 35  390 390 TYR TYR A . n 
A 1 36  GLN 36  391 391 GLN GLN A . n 
A 1 37  MET 37  392 392 MET MET A . n 
A 1 38  LYS 38  393 393 LYS LYS A . n 
A 1 39  LYS 39  394 394 LYS LYS A . n 
A 1 40  VAL 40  395 395 VAL VAL A . n 
A 1 41  VAL 41  396 396 VAL VAL A . n 
A 1 42  LYS 42  397 397 LYS LYS A . n 
A 1 43  THR 43  398 398 THR THR A . n 
A 1 44  VAL 44  399 399 VAL VAL A . n 
A 1 45  ALA 45  400 400 ALA ALA A . n 
A 1 46  VAL 46  401 401 VAL VAL A . n 
A 1 47  LYS 47  402 402 LYS LYS A . n 
A 1 48  ILE 48  403 403 ILE ILE A . n 
A 1 49  LEU 49  404 404 LEU LEU A . n 
A 1 50  LYS 50  405 405 LYS LYS A . n 
A 1 51  ASN 51  406 ?   ?   ?   A . n 
A 1 52  GLU 52  407 ?   ?   ?   A . n 
A 1 53  ALA 53  408 ?   ?   ?   A . n 
A 1 54  ASN 54  409 ?   ?   ?   A . n 
A 1 55  ASP 55  410 ?   ?   ?   A . n 
A 1 56  PRO 56  411 411 PRO PRO A . n 
A 1 57  ALA 57  412 412 ALA ALA A . n 
A 1 58  LEU 58  413 413 LEU LEU A . n 
A 1 59  LYS 59  414 414 LYS LYS A . n 
A 1 60  ASP 60  415 415 ASP ASP A . n 
A 1 61  GLU 61  416 416 GLU GLU A . n 
A 1 62  LEU 62  417 417 LEU LEU A . n 
A 1 63  LEU 63  418 418 LEU LEU A . n 
A 1 64  ALA 64  419 419 ALA ALA A . n 
A 1 65  GLU 65  420 420 GLU GLU A . n 
A 1 66  ALA 66  421 421 ALA ALA A . n 
A 1 67  ASN 67  422 422 ASN ASN A . n 
A 1 68  VAL 68  423 423 VAL VAL A . n 
A 1 69  MET 69  424 424 MET MET A . n 
A 1 70  GLN 70  425 425 GLN GLN A . n 
A 1 71  GLN 71  426 426 GLN GLN A . n 
A 1 72  LEU 72  427 427 LEU LEU A . n 
A 1 73  ASP 73  428 428 ASP ASP A . n 
A 1 74  ASN 74  429 429 ASN ASN A . n 
A 1 75  PRO 75  430 430 PRO PRO A . n 
A 1 76  TYR 76  431 431 TYR TYR A . n 
A 1 77  ILE 77  432 432 ILE ILE A . n 
A 1 78  VAL 78  433 433 VAL VAL A . n 
A 1 79  ARG 79  434 434 ARG ARG A . n 
A 1 80  MET 80  435 435 MET MET A . n 
A 1 81  ILE 81  436 436 ILE ILE A . n 
A 1 82  GLY 82  437 437 GLY GLY A . n 
A 1 83  ILE 83  438 438 ILE ILE A . n 
A 1 84  CYS 84  439 439 CYS CYS A . n 
A 1 85  GLU 85  440 440 GLU GLU A . n 
A 1 86  ALA 86  441 441 ALA ALA A . n 
A 1 87  GLU 87  442 442 GLU GLU A . n 
A 1 88  SER 88  443 443 SER SER A . n 
A 1 89  TRP 89  444 444 TRP TRP A . n 
A 1 90  MET 90  445 445 MET MET A . n 
A 1 91  LEU 91  446 446 LEU LEU A . n 
A 1 92  VAL 92  447 447 VAL VAL A . n 
A 1 93  MET 93  448 448 MET MET A . n 
A 1 94  GLU 94  449 449 GLU GLU A . n 
A 1 95  MET 95  450 450 MET MET A . n 
A 1 96  ALA 96  451 451 ALA ALA A . n 
A 1 97  GLU 97  452 452 GLU GLU A . n 
A 1 98  LEU 98  453 453 LEU LEU A . n 
A 1 99  GLY 99  454 454 GLY GLY A . n 
A 1 100 PRO 100 455 455 PRO PRO A . n 
A 1 101 LEU 101 456 456 LEU LEU A . n 
A 1 102 ASN 102 457 457 ASN ASN A . n 
A 1 103 LYS 103 458 458 LYS LYS A . n 
A 1 104 TYR 104 459 459 TYR TYR A . n 
A 1 105 LEU 105 460 460 LEU LEU A . n 
A 1 106 GLN 106 461 461 GLN GLN A . n 
A 1 107 GLN 107 462 462 GLN GLN A . n 
A 1 108 ASN 108 463 463 ASN ASN A . n 
A 1 109 ARG 109 464 464 ARG ARG A . n 
A 1 110 HIS 110 465 465 HIS HIS A . n 
A 1 111 VAL 111 466 466 VAL VAL A . n 
A 1 112 LYS 112 467 467 LYS LYS A . n 
A 1 113 ASP 113 468 468 ASP ASP A . n 
A 1 114 LYS 114 469 469 LYS LYS A . n 
A 1 115 ASN 115 470 470 ASN ASN A . n 
A 1 116 ILE 116 471 471 ILE ILE A . n 
A 1 117 ILE 117 472 472 ILE ILE A . n 
A 1 118 GLU 118 473 473 GLU GLU A . n 
A 1 119 LEU 119 474 474 LEU LEU A . n 
A 1 120 VAL 120 475 475 VAL VAL A . n 
A 1 121 HIS 121 476 476 HIS HIS A . n 
A 1 122 GLN 122 477 477 GLN GLN A . n 
A 1 123 VAL 123 478 478 VAL VAL A . n 
A 1 124 SER 124 479 479 SER SER A . n 
A 1 125 MET 125 480 480 MET MET A . n 
A 1 126 GLY 126 481 481 GLY GLY A . n 
A 1 127 MET 127 482 482 MET MET A . n 
A 1 128 LYS 128 483 483 LYS LYS A . n 
A 1 129 TYR 129 484 484 TYR TYR A . n 
A 1 130 LEU 130 485 485 LEU LEU A . n 
A 1 131 GLU 131 486 486 GLU GLU A . n 
A 1 132 GLU 132 487 487 GLU GLU A . n 
A 1 133 SER 133 488 488 SER SER A . n 
A 1 134 ASN 134 489 489 ASN ASN A . n 
A 1 135 PHE 135 490 490 PHE PHE A . n 
A 1 136 VAL 136 491 491 VAL VAL A . n 
A 1 137 HIS 137 492 492 HIS HIS A . n 
A 1 138 ARG 138 493 493 ARG ARG A . n 
A 1 139 ASP 139 494 494 ASP ASP A . n 
A 1 140 LEU 140 495 495 LEU LEU A . n 
A 1 141 ALA 141 496 496 ALA ALA A . n 
A 1 142 ALA 142 497 497 ALA ALA A . n 
A 1 143 ARG 143 498 498 ARG ARG A . n 
A 1 144 ASN 144 499 499 ASN ASN A . n 
A 1 145 VAL 145 500 500 VAL VAL A . n 
A 1 146 LEU 146 501 501 LEU LEU A . n 
A 1 147 LEU 147 502 502 LEU LEU A . n 
A 1 148 VAL 148 503 503 VAL VAL A . n 
A 1 149 THR 149 504 504 THR THR A . n 
A 1 150 GLN 150 505 505 GLN GLN A . n 
A 1 151 HIS 151 506 506 HIS HIS A . n 
A 1 152 TYR 152 507 507 TYR TYR A . n 
A 1 153 ALA 153 508 508 ALA ALA A . n 
A 1 154 LYS 154 509 509 LYS LYS A . n 
A 1 155 ILE 155 510 510 ILE ILE A . n 
A 1 156 SER 156 511 511 SER SER A . n 
A 1 157 ASP 157 512 512 ASP ASP A . n 
A 1 158 PHE 158 513 513 PHE PHE A . n 
A 1 159 GLY 159 514 514 GLY GLY A . n 
A 1 160 LEU 160 515 515 LEU LEU A . n 
A 1 161 SER 161 516 516 SER SER A . n 
A 1 162 LYS 162 517 517 LYS LYS A . n 
A 1 163 ALA 163 518 518 ALA ALA A . n 
A 1 164 LEU 164 519 519 LEU LEU A . n 
A 1 165 ARG 165 520 520 ARG ARG A . n 
A 1 166 ALA 166 521 521 ALA ALA A . n 
A 1 167 ASP 167 522 522 ASP ASP A . n 
A 1 168 GLU 168 523 523 GLU GLU A . n 
A 1 169 ASN 169 524 524 ASN ASN A . n 
A 1 170 TYR 170 525 525 TYR TYR A . n 
A 1 171 TYR 171 526 526 TYR TYR A . n 
A 1 172 LYS 172 527 527 LYS LYS A . n 
A 1 173 ALA 173 528 528 ALA ALA A . n 
A 1 174 GLN 174 529 529 GLN GLN A . n 
A 1 175 THR 175 530 ?   ?   ?   A . n 
A 1 176 HIS 176 531 ?   ?   ?   A . n 
A 1 177 GLY 177 532 ?   ?   ?   A . n 
A 1 178 LYS 178 533 533 LYS LYS A . n 
A 1 179 TRP 179 534 534 TRP TRP A . n 
A 1 180 PRO 180 535 535 PRO PRO A . n 
A 1 181 VAL 181 536 536 VAL VAL A . n 
A 1 182 LYS 182 537 537 LYS LYS A . n 
A 1 183 TRP 183 538 538 TRP TRP A . n 
A 1 184 TYR 184 539 539 TYR TYR A . n 
A 1 185 ALA 185 540 540 ALA ALA A . n 
A 1 186 PRO 186 541 541 PRO PRO A . n 
A 1 187 GLU 187 542 542 GLU GLU A . n 
A 1 188 CYS 188 543 543 CYS CYS A . n 
A 1 189 ILE 189 544 544 ILE ILE A . n 
A 1 190 ASN 190 545 545 ASN ASN A . n 
A 1 191 TYR 191 546 546 TYR TYR A . n 
A 1 192 TYR 192 547 547 TYR TYR A . n 
A 1 193 LYS 193 548 548 LYS LYS A . n 
A 1 194 PHE 194 549 549 PHE PHE A . n 
A 1 195 SER 195 550 550 SER SER A . n 
A 1 196 SER 196 551 551 SER SER A . n 
A 1 197 LYS 197 552 552 LYS LYS A . n 
A 1 198 SER 198 553 553 SER SER A . n 
A 1 199 ASP 199 554 554 ASP ASP A . n 
A 1 200 VAL 200 555 555 VAL VAL A . n 
A 1 201 TRP 201 556 556 TRP TRP A . n 
A 1 202 SER 202 557 557 SER SER A . n 
A 1 203 PHE 203 558 558 PHE PHE A . n 
A 1 204 GLY 204 559 559 GLY GLY A . n 
A 1 205 VAL 205 560 560 VAL VAL A . n 
A 1 206 LEU 206 561 561 LEU LEU A . n 
A 1 207 MET 207 562 562 MET MET A . n 
A 1 208 TRP 208 563 563 TRP TRP A . n 
A 1 209 GLU 209 564 564 GLU GLU A . n 
A 1 210 ALA 210 565 565 ALA ALA A . n 
A 1 211 PHE 211 566 566 PHE PHE A . n 
A 1 212 SER 212 567 567 SER SER A . n 
A 1 213 TYR 213 568 568 TYR TYR A . n 
A 1 214 GLY 214 569 569 GLY GLY A . n 
A 1 215 GLN 215 570 570 GLN GLN A . n 
A 1 216 LYS 216 571 571 LYS LYS A . n 
A 1 217 PRO 217 572 572 PRO PRO A . n 
A 1 218 TYR 218 573 573 TYR TYR A . n 
A 1 219 ARG 219 574 574 ARG ARG A . n 
A 1 220 GLY 220 575 575 GLY GLY A . n 
A 1 221 MET 221 576 576 MET MET A . n 
A 1 222 LYS 222 577 577 LYS LYS A . n 
A 1 223 GLY 223 578 578 GLY GLY A . n 
A 1 224 SER 224 579 579 SER SER A . n 
A 1 225 GLU 225 580 580 GLU GLU A . n 
A 1 226 VAL 226 581 581 VAL VAL A . n 
A 1 227 THR 227 582 582 THR THR A . n 
A 1 228 ALA 228 583 583 ALA ALA A . n 
A 1 229 MET 229 584 584 MET MET A . n 
A 1 230 LEU 230 585 585 LEU LEU A . n 
A 1 231 GLU 231 586 586 GLU GLU A . n 
A 1 232 LYS 232 587 587 LYS LYS A . n 
A 1 233 GLY 233 588 588 GLY GLY A . n 
A 1 234 GLU 234 589 589 GLU GLU A . n 
A 1 235 ARG 235 590 590 ARG ARG A . n 
A 1 236 MET 236 591 591 MET MET A . n 
A 1 237 GLY 237 592 592 GLY GLY A . n 
A 1 238 CYS 238 593 593 CYS CYS A . n 
A 1 239 PRO 239 594 594 PRO PRO A . n 
A 1 240 ALA 240 595 595 ALA ALA A . n 
A 1 241 GLY 241 596 596 GLY GLY A . n 
A 1 242 CYS 242 597 597 CYS CYS A . n 
A 1 243 PRO 243 598 598 PRO PRO A . n 
A 1 244 ARG 244 599 599 ARG ARG A . n 
A 1 245 GLU 245 600 600 GLU GLU A . n 
A 1 246 MET 246 601 601 MET MET A . n 
A 1 247 TYR 247 602 602 TYR TYR A . n 
A 1 248 ASP 248 603 603 ASP ASP A . n 
A 1 249 LEU 249 604 604 LEU LEU A . n 
A 1 250 MET 250 605 605 MET MET A . n 
A 1 251 ASN 251 606 606 ASN ASN A . n 
A 1 252 LEU 252 607 607 LEU LEU A . n 
A 1 253 CYS 253 608 608 CYS CYS A . n 
A 1 254 TRP 254 609 609 TRP TRP A . n 
A 1 255 THR 255 610 610 THR THR A . n 
A 1 256 TYR 256 611 611 TYR TYR A . n 
A 1 257 ASP 257 612 612 ASP ASP A . n 
A 1 258 VAL 258 613 613 VAL VAL A . n 
A 1 259 GLU 259 614 614 GLU GLU A . n 
A 1 260 ASN 260 615 615 ASN ASN A . n 
A 1 261 ARG 261 616 616 ARG ARG A . n 
A 1 262 PRO 262 617 617 PRO PRO A . n 
A 1 263 GLY 263 618 618 GLY GLY A . n 
A 1 264 PHE 264 619 619 PHE PHE A . n 
A 1 265 ALA 265 620 620 ALA ALA A . n 
A 1 266 ALA 266 621 621 ALA ALA A . n 
A 1 267 VAL 267 622 622 VAL VAL A . n 
A 1 268 GLU 268 623 623 GLU GLU A . n 
A 1 269 LEU 269 624 624 LEU LEU A . n 
A 1 270 ARG 270 625 625 ARG ARG A . n 
A 1 271 LEU 271 626 626 LEU LEU A . n 
A 1 272 ARG 272 627 627 ARG ARG A . n 
A 1 273 ASN 273 628 628 ASN ASN A . n 
A 1 274 TYR 274 629 629 TYR TYR A . n 
A 1 275 TYR 275 630 630 TYR TYR A . n 
A 1 276 TYR 276 631 631 TYR TYR A . n 
A 1 277 ASP 277 632 632 ASP ASP A . n 
A 1 278 VAL 278 633 633 VAL VAL A . n 
A 1 279 VAL 279 634 634 VAL VAL A . n 
A 1 280 ASN 280 635 ?   ?   ?   A . n 
A 1 281 LEU 281 636 ?   ?   ?   A . n 
A 1 282 GLU 282 637 ?   ?   ?   A . n 
A 1 283 HIS 283 638 ?   ?   ?   A . n 
A 1 284 HIS 284 639 ?   ?   ?   A . n 
A 1 285 HIS 285 640 ?   ?   ?   A . n 
A 1 286 HIS 286 641 ?   ?   ?   A . n 
A 1 287 HIS 287 642 ?   ?   ?   A . n 
A 1 288 HIS 288 643 ?   ?   ?   A . n 
A 1 289 HIS 289 644 ?   ?   ?   A . n 
A 1 290 HIS 290 645 ?   ?   ?   A . n 
B 1 1   GLU 1   356 ?   ?   ?   B . n 
B 1 2   GLU 2   357 ?   ?   ?   B . n 
B 1 3   ILE 3   358 ?   ?   ?   B . n 
B 1 4   ARG 4   359 ?   ?   ?   B . n 
B 1 5   PRO 5   360 ?   ?   ?   B . n 
B 1 6   LYS 6   361 ?   ?   ?   B . n 
B 1 7   GLU 7   362 ?   ?   ?   B . n 
B 1 8   VAL 8   363 ?   ?   ?   B . n 
B 1 9   TYR 9   364 364 TYR TYR B . n 
B 1 10  LEU 10  365 365 LEU LEU B . n 
B 1 11  ASP 11  366 366 ASP ASP B . n 
B 1 12  ARG 12  367 367 ARG ARG B . n 
B 1 13  LYS 13  368 368 LYS LYS B . n 
B 1 14  LEU 14  369 369 LEU LEU B . n 
B 1 15  LEU 15  370 370 LEU LEU B . n 
B 1 16  THR 16  371 371 THR THR B . n 
B 1 17  LEU 17  372 372 LEU LEU B . n 
B 1 18  GLU 18  373 373 GLU GLU B . n 
B 1 19  ASP 19  374 374 ASP ASP B . n 
B 1 20  LYS 20  375 375 LYS LYS B . n 
B 1 21  GLU 21  376 376 GLU GLU B . n 
B 1 22  LEU 22  377 377 LEU LEU B . n 
B 1 23  GLY 23  378 378 GLY GLY B . n 
B 1 24  SER 24  379 379 SER SER B . n 
B 1 25  GLY 25  380 380 GLY GLY B . n 
B 1 26  ASN 26  381 381 ASN ASN B . n 
B 1 27  PHE 27  382 382 PHE PHE B . n 
B 1 28  GLY 28  383 383 GLY GLY B . n 
B 1 29  THR 29  384 384 THR THR B . n 
B 1 30  VAL 30  385 385 VAL VAL B . n 
B 1 31  LYS 31  386 386 LYS LYS B . n 
B 1 32  LYS 32  387 387 LYS LYS B . n 
B 1 33  GLY 33  388 388 GLY GLY B . n 
B 1 34  TYR 34  389 389 TYR TYR B . n 
B 1 35  TYR 35  390 390 TYR TYR B . n 
B 1 36  GLN 36  391 391 GLN GLN B . n 
B 1 37  MET 37  392 392 MET MET B . n 
B 1 38  LYS 38  393 393 LYS LYS B . n 
B 1 39  LYS 39  394 394 LYS LYS B . n 
B 1 40  VAL 40  395 395 VAL VAL B . n 
B 1 41  VAL 41  396 396 VAL VAL B . n 
B 1 42  LYS 42  397 397 LYS LYS B . n 
B 1 43  THR 43  398 398 THR THR B . n 
B 1 44  VAL 44  399 399 VAL VAL B . n 
B 1 45  ALA 45  400 400 ALA ALA B . n 
B 1 46  VAL 46  401 401 VAL VAL B . n 
B 1 47  LYS 47  402 402 LYS LYS B . n 
B 1 48  ILE 48  403 403 ILE ILE B . n 
B 1 49  LEU 49  404 404 LEU LEU B . n 
B 1 50  LYS 50  405 405 LYS LYS B . n 
B 1 51  ASN 51  406 ?   ?   ?   B . n 
B 1 52  GLU 52  407 ?   ?   ?   B . n 
B 1 53  ALA 53  408 ?   ?   ?   B . n 
B 1 54  ASN 54  409 ?   ?   ?   B . n 
B 1 55  ASP 55  410 ?   ?   ?   B . n 
B 1 56  PRO 56  411 411 PRO PRO B . n 
B 1 57  ALA 57  412 412 ALA ALA B . n 
B 1 58  LEU 58  413 413 LEU LEU B . n 
B 1 59  LYS 59  414 414 LYS LYS B . n 
B 1 60  ASP 60  415 415 ASP ASP B . n 
B 1 61  GLU 61  416 416 GLU GLU B . n 
B 1 62  LEU 62  417 417 LEU LEU B . n 
B 1 63  LEU 63  418 418 LEU LEU B . n 
B 1 64  ALA 64  419 419 ALA ALA B . n 
B 1 65  GLU 65  420 420 GLU GLU B . n 
B 1 66  ALA 66  421 421 ALA ALA B . n 
B 1 67  ASN 67  422 422 ASN ASN B . n 
B 1 68  VAL 68  423 423 VAL VAL B . n 
B 1 69  MET 69  424 424 MET MET B . n 
B 1 70  GLN 70  425 425 GLN GLN B . n 
B 1 71  GLN 71  426 426 GLN GLN B . n 
B 1 72  LEU 72  427 427 LEU LEU B . n 
B 1 73  ASP 73  428 428 ASP ASP B . n 
B 1 74  ASN 74  429 429 ASN ASN B . n 
B 1 75  PRO 75  430 430 PRO PRO B . n 
B 1 76  TYR 76  431 431 TYR TYR B . n 
B 1 77  ILE 77  432 432 ILE ILE B . n 
B 1 78  VAL 78  433 433 VAL VAL B . n 
B 1 79  ARG 79  434 434 ARG ARG B . n 
B 1 80  MET 80  435 435 MET MET B . n 
B 1 81  ILE 81  436 436 ILE ILE B . n 
B 1 82  GLY 82  437 437 GLY GLY B . n 
B 1 83  ILE 83  438 438 ILE ILE B . n 
B 1 84  CYS 84  439 439 CYS CYS B . n 
B 1 85  GLU 85  440 440 GLU GLU B . n 
B 1 86  ALA 86  441 441 ALA ALA B . n 
B 1 87  GLU 87  442 442 GLU GLU B . n 
B 1 88  SER 88  443 443 SER SER B . n 
B 1 89  TRP 89  444 444 TRP TRP B . n 
B 1 90  MET 90  445 445 MET MET B . n 
B 1 91  LEU 91  446 446 LEU LEU B . n 
B 1 92  VAL 92  447 447 VAL VAL B . n 
B 1 93  MET 93  448 448 MET MET B . n 
B 1 94  GLU 94  449 449 GLU GLU B . n 
B 1 95  MET 95  450 450 MET MET B . n 
B 1 96  ALA 96  451 451 ALA ALA B . n 
B 1 97  GLU 97  452 452 GLU GLU B . n 
B 1 98  LEU 98  453 453 LEU LEU B . n 
B 1 99  GLY 99  454 454 GLY GLY B . n 
B 1 100 PRO 100 455 455 PRO PRO B . n 
B 1 101 LEU 101 456 456 LEU LEU B . n 
B 1 102 ASN 102 457 457 ASN ASN B . n 
B 1 103 LYS 103 458 458 LYS LYS B . n 
B 1 104 TYR 104 459 459 TYR TYR B . n 
B 1 105 LEU 105 460 460 LEU LEU B . n 
B 1 106 GLN 106 461 461 GLN GLN B . n 
B 1 107 GLN 107 462 462 GLN GLN B . n 
B 1 108 ASN 108 463 463 ASN ASN B . n 
B 1 109 ARG 109 464 464 ARG ARG B . n 
B 1 110 HIS 110 465 465 HIS HIS B . n 
B 1 111 VAL 111 466 466 VAL VAL B . n 
B 1 112 LYS 112 467 467 LYS LYS B . n 
B 1 113 ASP 113 468 468 ASP ASP B . n 
B 1 114 LYS 114 469 469 LYS LYS B . n 
B 1 115 ASN 115 470 470 ASN ASN B . n 
B 1 116 ILE 116 471 471 ILE ILE B . n 
B 1 117 ILE 117 472 472 ILE ILE B . n 
B 1 118 GLU 118 473 473 GLU GLU B . n 
B 1 119 LEU 119 474 474 LEU LEU B . n 
B 1 120 VAL 120 475 475 VAL VAL B . n 
B 1 121 HIS 121 476 476 HIS HIS B . n 
B 1 122 GLN 122 477 477 GLN GLN B . n 
B 1 123 VAL 123 478 478 VAL VAL B . n 
B 1 124 SER 124 479 479 SER SER B . n 
B 1 125 MET 125 480 480 MET MET B . n 
B 1 126 GLY 126 481 481 GLY GLY B . n 
B 1 127 MET 127 482 482 MET MET B . n 
B 1 128 LYS 128 483 483 LYS LYS B . n 
B 1 129 TYR 129 484 484 TYR TYR B . n 
B 1 130 LEU 130 485 485 LEU LEU B . n 
B 1 131 GLU 131 486 486 GLU GLU B . n 
B 1 132 GLU 132 487 487 GLU GLU B . n 
B 1 133 SER 133 488 488 SER SER B . n 
B 1 134 ASN 134 489 489 ASN ASN B . n 
B 1 135 PHE 135 490 490 PHE PHE B . n 
B 1 136 VAL 136 491 491 VAL VAL B . n 
B 1 137 HIS 137 492 492 HIS HIS B . n 
B 1 138 ARG 138 493 493 ARG ARG B . n 
B 1 139 ASP 139 494 494 ASP ASP B . n 
B 1 140 LEU 140 495 495 LEU LEU B . n 
B 1 141 ALA 141 496 496 ALA ALA B . n 
B 1 142 ALA 142 497 497 ALA ALA B . n 
B 1 143 ARG 143 498 498 ARG ARG B . n 
B 1 144 ASN 144 499 499 ASN ASN B . n 
B 1 145 VAL 145 500 500 VAL VAL B . n 
B 1 146 LEU 146 501 501 LEU LEU B . n 
B 1 147 LEU 147 502 502 LEU LEU B . n 
B 1 148 VAL 148 503 503 VAL VAL B . n 
B 1 149 THR 149 504 504 THR THR B . n 
B 1 150 GLN 150 505 505 GLN GLN B . n 
B 1 151 HIS 151 506 506 HIS HIS B . n 
B 1 152 TYR 152 507 507 TYR TYR B . n 
B 1 153 ALA 153 508 508 ALA ALA B . n 
B 1 154 LYS 154 509 509 LYS LYS B . n 
B 1 155 ILE 155 510 510 ILE ILE B . n 
B 1 156 SER 156 511 511 SER SER B . n 
B 1 157 ASP 157 512 512 ASP ASP B . n 
B 1 158 PHE 158 513 513 PHE PHE B . n 
B 1 159 GLY 159 514 514 GLY GLY B . n 
B 1 160 LEU 160 515 515 LEU LEU B . n 
B 1 161 SER 161 516 516 SER SER B . n 
B 1 162 LYS 162 517 517 LYS LYS B . n 
B 1 163 ALA 163 518 518 ALA ALA B . n 
B 1 164 LEU 164 519 519 LEU LEU B . n 
B 1 165 ARG 165 520 520 ARG ARG B . n 
B 1 166 ALA 166 521 521 ALA ALA B . n 
B 1 167 ASP 167 522 522 ASP ASP B . n 
B 1 168 GLU 168 523 523 GLU GLU B . n 
B 1 169 ASN 169 524 524 ASN ASN B . n 
B 1 170 TYR 170 525 525 TYR TYR B . n 
B 1 171 TYR 171 526 526 TYR TYR B . n 
B 1 172 LYS 172 527 527 LYS LYS B . n 
B 1 173 ALA 173 528 528 ALA ALA B . n 
B 1 174 GLN 174 529 529 GLN GLN B . n 
B 1 175 THR 175 530 ?   ?   ?   B . n 
B 1 176 HIS 176 531 ?   ?   ?   B . n 
B 1 177 GLY 177 532 ?   ?   ?   B . n 
B 1 178 LYS 178 533 533 LYS LYS B . n 
B 1 179 TRP 179 534 534 TRP TRP B . n 
B 1 180 PRO 180 535 535 PRO PRO B . n 
B 1 181 VAL 181 536 536 VAL VAL B . n 
B 1 182 LYS 182 537 537 LYS LYS B . n 
B 1 183 TRP 183 538 538 TRP TRP B . n 
B 1 184 TYR 184 539 539 TYR TYR B . n 
B 1 185 ALA 185 540 540 ALA ALA B . n 
B 1 186 PRO 186 541 541 PRO PRO B . n 
B 1 187 GLU 187 542 542 GLU GLU B . n 
B 1 188 CYS 188 543 543 CYS CYS B . n 
B 1 189 ILE 189 544 544 ILE ILE B . n 
B 1 190 ASN 190 545 545 ASN ASN B . n 
B 1 191 TYR 191 546 546 TYR TYR B . n 
B 1 192 TYR 192 547 547 TYR TYR B . n 
B 1 193 LYS 193 548 548 LYS LYS B . n 
B 1 194 PHE 194 549 549 PHE PHE B . n 
B 1 195 SER 195 550 550 SER SER B . n 
B 1 196 SER 196 551 551 SER SER B . n 
B 1 197 LYS 197 552 552 LYS LYS B . n 
B 1 198 SER 198 553 553 SER SER B . n 
B 1 199 ASP 199 554 554 ASP ASP B . n 
B 1 200 VAL 200 555 555 VAL VAL B . n 
B 1 201 TRP 201 556 556 TRP TRP B . n 
B 1 202 SER 202 557 557 SER SER B . n 
B 1 203 PHE 203 558 558 PHE PHE B . n 
B 1 204 GLY 204 559 559 GLY GLY B . n 
B 1 205 VAL 205 560 560 VAL VAL B . n 
B 1 206 LEU 206 561 561 LEU LEU B . n 
B 1 207 MET 207 562 562 MET MET B . n 
B 1 208 TRP 208 563 563 TRP TRP B . n 
B 1 209 GLU 209 564 564 GLU GLU B . n 
B 1 210 ALA 210 565 565 ALA ALA B . n 
B 1 211 PHE 211 566 566 PHE PHE B . n 
B 1 212 SER 212 567 567 SER SER B . n 
B 1 213 TYR 213 568 568 TYR TYR B . n 
B 1 214 GLY 214 569 569 GLY GLY B . n 
B 1 215 GLN 215 570 570 GLN GLN B . n 
B 1 216 LYS 216 571 571 LYS LYS B . n 
B 1 217 PRO 217 572 572 PRO PRO B . n 
B 1 218 TYR 218 573 573 TYR TYR B . n 
B 1 219 ARG 219 574 574 ARG ARG B . n 
B 1 220 GLY 220 575 575 GLY GLY B . n 
B 1 221 MET 221 576 576 MET MET B . n 
B 1 222 LYS 222 577 577 LYS LYS B . n 
B 1 223 GLY 223 578 578 GLY GLY B . n 
B 1 224 SER 224 579 579 SER SER B . n 
B 1 225 GLU 225 580 580 GLU GLU B . n 
B 1 226 VAL 226 581 581 VAL VAL B . n 
B 1 227 THR 227 582 582 THR THR B . n 
B 1 228 ALA 228 583 583 ALA ALA B . n 
B 1 229 MET 229 584 584 MET MET B . n 
B 1 230 LEU 230 585 585 LEU LEU B . n 
B 1 231 GLU 231 586 586 GLU GLU B . n 
B 1 232 LYS 232 587 587 LYS LYS B . n 
B 1 233 GLY 233 588 588 GLY GLY B . n 
B 1 234 GLU 234 589 589 GLU GLU B . n 
B 1 235 ARG 235 590 590 ARG ARG B . n 
B 1 236 MET 236 591 591 MET MET B . n 
B 1 237 GLY 237 592 592 GLY GLY B . n 
B 1 238 CYS 238 593 593 CYS CYS B . n 
B 1 239 PRO 239 594 594 PRO PRO B . n 
B 1 240 ALA 240 595 595 ALA ALA B . n 
B 1 241 GLY 241 596 596 GLY GLY B . n 
B 1 242 CYS 242 597 597 CYS CYS B . n 
B 1 243 PRO 243 598 598 PRO PRO B . n 
B 1 244 ARG 244 599 599 ARG ARG B . n 
B 1 245 GLU 245 600 600 GLU GLU B . n 
B 1 246 MET 246 601 601 MET MET B . n 
B 1 247 TYR 247 602 602 TYR TYR B . n 
B 1 248 ASP 248 603 603 ASP ASP B . n 
B 1 249 LEU 249 604 604 LEU LEU B . n 
B 1 250 MET 250 605 605 MET MET B . n 
B 1 251 ASN 251 606 606 ASN ASN B . n 
B 1 252 LEU 252 607 607 LEU LEU B . n 
B 1 253 CYS 253 608 608 CYS CYS B . n 
B 1 254 TRP 254 609 609 TRP TRP B . n 
B 1 255 THR 255 610 610 THR THR B . n 
B 1 256 TYR 256 611 611 TYR TYR B . n 
B 1 257 ASP 257 612 612 ASP ASP B . n 
B 1 258 VAL 258 613 613 VAL VAL B . n 
B 1 259 GLU 259 614 614 GLU GLU B . n 
B 1 260 ASN 260 615 615 ASN ASN B . n 
B 1 261 ARG 261 616 616 ARG ARG B . n 
B 1 262 PRO 262 617 617 PRO PRO B . n 
B 1 263 GLY 263 618 618 GLY GLY B . n 
B 1 264 PHE 264 619 619 PHE PHE B . n 
B 1 265 ALA 265 620 620 ALA ALA B . n 
B 1 266 ALA 266 621 621 ALA ALA B . n 
B 1 267 VAL 267 622 622 VAL VAL B . n 
B 1 268 GLU 268 623 623 GLU GLU B . n 
B 1 269 LEU 269 624 624 LEU LEU B . n 
B 1 270 ARG 270 625 625 ARG ARG B . n 
B 1 271 LEU 271 626 626 LEU LEU B . n 
B 1 272 ARG 272 627 627 ARG ARG B . n 
B 1 273 ASN 273 628 628 ASN ASN B . n 
B 1 274 TYR 274 629 629 TYR TYR B . n 
B 1 275 TYR 275 630 630 TYR TYR B . n 
B 1 276 TYR 276 631 631 TYR TYR B . n 
B 1 277 ASP 277 632 632 ASP ASP B . n 
B 1 278 VAL 278 633 633 VAL VAL B . n 
B 1 279 VAL 279 634 634 VAL VAL B . n 
B 1 280 ASN 280 635 ?   ?   ?   B . n 
B 1 281 LEU 281 636 ?   ?   ?   B . n 
B 1 282 GLU 282 637 ?   ?   ?   B . n 
B 1 283 HIS 283 638 ?   ?   ?   B . n 
B 1 284 HIS 284 639 ?   ?   ?   B . n 
B 1 285 HIS 285 640 ?   ?   ?   B . n 
B 1 286 HIS 286 641 ?   ?   ?   B . n 
B 1 287 HIS 287 642 ?   ?   ?   B . n 
B 1 288 HIS 288 643 ?   ?   ?   B . n 
B 1 289 HIS 289 644 ?   ?   ?   B . n 
B 1 290 HIS 290 645 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LV6 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LV6 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 A1LV6 1   901  901 A1LV6 LIG A . 
D 2 A1LV6 1   901  901 A1LV6 LIG B . 
E 3 HOH   1   1001 86  HOH   HOH A . 
E 3 HOH   2   1002 269 HOH   HOH A . 
E 3 HOH   3   1003 280 HOH   HOH A . 
E 3 HOH   4   1004 137 HOH   HOH A . 
E 3 HOH   5   1005 83  HOH   HOH A . 
E 3 HOH   6   1006 216 HOH   HOH A . 
E 3 HOH   7   1007 329 HOH   HOH A . 
E 3 HOH   8   1008 282 HOH   HOH A . 
E 3 HOH   9   1009 209 HOH   HOH A . 
E 3 HOH   10  1010 150 HOH   HOH A . 
E 3 HOH   11  1011 11  HOH   HOH A . 
E 3 HOH   12  1012 285 HOH   HOH A . 
E 3 HOH   13  1013 220 HOH   HOH A . 
E 3 HOH   14  1014 9   HOH   HOH A . 
E 3 HOH   15  1015 310 HOH   HOH A . 
E 3 HOH   16  1016 66  HOH   HOH A . 
E 3 HOH   17  1017 135 HOH   HOH A . 
E 3 HOH   18  1018 201 HOH   HOH A . 
E 3 HOH   19  1019 16  HOH   HOH A . 
E 3 HOH   20  1020 252 HOH   HOH A . 
E 3 HOH   21  1021 218 HOH   HOH A . 
E 3 HOH   22  1022 8   HOH   HOH A . 
E 3 HOH   23  1023 312 HOH   HOH A . 
E 3 HOH   24  1024 279 HOH   HOH A . 
E 3 HOH   25  1025 217 HOH   HOH A . 
E 3 HOH   26  1026 138 HOH   HOH A . 
E 3 HOH   27  1027 60  HOH   HOH A . 
E 3 HOH   28  1028 68  HOH   HOH A . 
E 3 HOH   29  1029 50  HOH   HOH A . 
E 3 HOH   30  1030 59  HOH   HOH A . 
E 3 HOH   31  1031 234 HOH   HOH A . 
E 3 HOH   32  1032 47  HOH   HOH A . 
E 3 HOH   33  1033 146 HOH   HOH A . 
E 3 HOH   34  1034 185 HOH   HOH A . 
E 3 HOH   35  1035 149 HOH   HOH A . 
E 3 HOH   36  1036 199 HOH   HOH A . 
E 3 HOH   37  1037 188 HOH   HOH A . 
E 3 HOH   38  1038 14  HOH   HOH A . 
E 3 HOH   39  1039 255 HOH   HOH A . 
E 3 HOH   40  1040 187 HOH   HOH A . 
E 3 HOH   41  1041 69  HOH   HOH A . 
E 3 HOH   42  1042 211 HOH   HOH A . 
E 3 HOH   43  1043 139 HOH   HOH A . 
E 3 HOH   44  1044 141 HOH   HOH A . 
E 3 HOH   45  1045 61  HOH   HOH A . 
E 3 HOH   46  1046 51  HOH   HOH A . 
E 3 HOH   47  1047 15  HOH   HOH A . 
E 3 HOH   48  1048 71  HOH   HOH A . 
E 3 HOH   49  1049 189 HOH   HOH A . 
E 3 HOH   50  1050 77  HOH   HOH A . 
E 3 HOH   51  1051 12  HOH   HOH A . 
E 3 HOH   52  1052 76  HOH   HOH A . 
E 3 HOH   53  1053 79  HOH   HOH A . 
E 3 HOH   54  1054 204 HOH   HOH A . 
E 3 HOH   55  1055 72  HOH   HOH A . 
E 3 HOH   56  1056 132 HOH   HOH A . 
E 3 HOH   57  1057 5   HOH   HOH A . 
E 3 HOH   58  1058 81  HOH   HOH A . 
E 3 HOH   59  1059 90  HOH   HOH A . 
E 3 HOH   60  1060 48  HOH   HOH A . 
E 3 HOH   61  1061 133 HOH   HOH A . 
E 3 HOH   62  1062 151 HOH   HOH A . 
E 3 HOH   63  1063 54  HOH   HOH A . 
E 3 HOH   64  1064 213 HOH   HOH A . 
E 3 HOH   65  1065 148 HOH   HOH A . 
E 3 HOH   66  1066 10  HOH   HOH A . 
E 3 HOH   67  1067 210 HOH   HOH A . 
E 3 HOH   68  1068 63  HOH   HOH A . 
E 3 HOH   69  1069 214 HOH   HOH A . 
E 3 HOH   70  1070 335 HOH   HOH A . 
E 3 HOH   71  1071 314 HOH   HOH A . 
E 3 HOH   72  1072 231 HOH   HOH A . 
E 3 HOH   73  1073 336 HOH   HOH A . 
E 3 HOH   74  1074 134 HOH   HOH A . 
E 3 HOH   75  1075 147 HOH   HOH A . 
E 3 HOH   76  1076 202 HOH   HOH A . 
E 3 HOH   77  1077 281 HOH   HOH A . 
E 3 HOH   78  1078 88  HOH   HOH A . 
E 3 HOH   79  1079 271 HOH   HOH A . 
E 3 HOH   80  1080 253 HOH   HOH A . 
E 3 HOH   81  1081 142 HOH   HOH A . 
E 3 HOH   82  1082 87  HOH   HOH A . 
E 3 HOH   83  1083 251 HOH   HOH A . 
E 3 HOH   84  1084 136 HOH   HOH A . 
E 3 HOH   85  1085 283 HOH   HOH A . 
E 3 HOH   86  1086 64  HOH   HOH A . 
E 3 HOH   87  1087 49  HOH   HOH A . 
E 3 HOH   88  1088 173 HOH   HOH A . 
E 3 HOH   89  1089 53  HOH   HOH A . 
E 3 HOH   90  1090 268 HOH   HOH A . 
E 3 HOH   91  1091 74  HOH   HOH A . 
E 3 HOH   92  1092 55  HOH   HOH A . 
E 3 HOH   93  1093 62  HOH   HOH A . 
E 3 HOH   94  1094 152 HOH   HOH A . 
E 3 HOH   95  1095 56  HOH   HOH A . 
E 3 HOH   96  1096 73  HOH   HOH A . 
E 3 HOH   97  1097 57  HOH   HOH A . 
E 3 HOH   98  1098 89  HOH   HOH A . 
E 3 HOH   99  1099 6   HOH   HOH A . 
E 3 HOH   100 1100 156 HOH   HOH A . 
E 3 HOH   101 1101 270 HOH   HOH A . 
E 3 HOH   102 1102 284 HOH   HOH A . 
E 3 HOH   103 1103 82  HOH   HOH A . 
E 3 HOH   104 1104 17  HOH   HOH A . 
E 3 HOH   105 1105 75  HOH   HOH A . 
E 3 HOH   106 1106 212 HOH   HOH A . 
E 3 HOH   107 1107 219 HOH   HOH A . 
E 3 HOH   108 1108 203 HOH   HOH A . 
E 3 HOH   109 1109 7   HOH   HOH A . 
E 3 HOH   110 1110 13  HOH   HOH A . 
E 3 HOH   111 1111 52  HOH   HOH A . 
E 3 HOH   112 1112 184 HOH   HOH A . 
E 3 HOH   113 1113 85  HOH   HOH A . 
E 3 HOH   114 1114 145 HOH   HOH A . 
E 3 HOH   115 1115 274 HOH   HOH A . 
E 3 HOH   116 1116 328 HOH   HOH A . 
E 3 HOH   117 1117 70  HOH   HOH A . 
E 3 HOH   118 1118 208 HOH   HOH A . 
E 3 HOH   119 1119 131 HOH   HOH A . 
E 3 HOH   120 1120 337 HOH   HOH A . 
E 3 HOH   121 1121 232 HOH   HOH A . 
E 3 HOH   122 1122 275 HOH   HOH A . 
E 3 HOH   123 1123 221 HOH   HOH A . 
E 3 HOH   124 1124 155 HOH   HOH A . 
E 3 HOH   125 1125 313 HOH   HOH A . 
E 3 HOH   126 1126 233 HOH   HOH A . 
E 3 HOH   127 1127 257 HOH   HOH A . 
E 3 HOH   128 1128 84  HOH   HOH A . 
E 3 HOH   129 1129 78  HOH   HOH A . 
E 3 HOH   130 1130 91  HOH   HOH A . 
E 3 HOH   131 1131 327 HOH   HOH A . 
E 3 HOH   132 1132 309 HOH   HOH A . 
E 3 HOH   133 1133 154 HOH   HOH A . 
E 3 HOH   134 1134 190 HOH   HOH A . 
E 3 HOH   135 1135 144 HOH   HOH A . 
E 3 HOH   136 1136 278 HOH   HOH A . 
E 3 HOH   137 1137 153 HOH   HOH A . 
E 3 HOH   138 1138 334 HOH   HOH A . 
E 3 HOH   139 1139 67  HOH   HOH A . 
E 3 HOH   140 1140 254 HOH   HOH A . 
E 3 HOH   141 1141 227 HOH   HOH A . 
E 3 HOH   142 1142 286 HOH   HOH A . 
E 3 HOH   143 1143 157 HOH   HOH A . 
E 3 HOH   144 1144 277 HOH   HOH A . 
E 3 HOH   145 1145 65  HOH   HOH A . 
E 3 HOH   146 1146 338 HOH   HOH A . 
E 3 HOH   147 1147 276 HOH   HOH A . 
E 3 HOH   148 1148 58  HOH   HOH A . 
E 3 HOH   149 1149 186 HOH   HOH A . 
E 3 HOH   150 1150 256 HOH   HOH A . 
E 3 HOH   151 1151 260 HOH   HOH A . 
E 3 HOH   152 1152 311 HOH   HOH A . 
F 3 HOH   1   1001 332 HOH   HOH B . 
F 3 HOH   2   1002 39  HOH   HOH B . 
F 3 HOH   3   1003 331 HOH   HOH B . 
F 3 HOH   4   1004 41  HOH   HOH B . 
F 3 HOH   5   1005 122 HOH   HOH B . 
F 3 HOH   6   1006 241 HOH   HOH B . 
F 3 HOH   7   1007 320 HOH   HOH B . 
F 3 HOH   8   1008 324 HOH   HOH B . 
F 3 HOH   9   1009 167 HOH   HOH B . 
F 3 HOH   10  1010 317 HOH   HOH B . 
F 3 HOH   11  1011 105 HOH   HOH B . 
F 3 HOH   12  1012 107 HOH   HOH B . 
F 3 HOH   13  1013 179 HOH   HOH B . 
F 3 HOH   14  1014 321 HOH   HOH B . 
F 3 HOH   15  1015 178 HOH   HOH B . 
F 3 HOH   16  1016 171 HOH   HOH B . 
F 3 HOH   17  1017 22  HOH   HOH B . 
F 3 HOH   18  1018 181 HOH   HOH B . 
F 3 HOH   19  1019 106 HOH   HOH B . 
F 3 HOH   20  1020 30  HOH   HOH B . 
F 3 HOH   21  1021 289 HOH   HOH B . 
F 3 HOH   22  1022 99  HOH   HOH B . 
F 3 HOH   23  1023 35  HOH   HOH B . 
F 3 HOH   24  1024 29  HOH   HOH B . 
F 3 HOH   25  1025 164 HOH   HOH B . 
F 3 HOH   26  1026 205 HOH   HOH B . 
F 3 HOH   27  1027 263 HOH   HOH B . 
F 3 HOH   28  1028 95  HOH   HOH B . 
F 3 HOH   29  1029 45  HOH   HOH B . 
F 3 HOH   30  1030 292 HOH   HOH B . 
F 3 HOH   31  1031 101 HOH   HOH B . 
F 3 HOH   32  1032 108 HOH   HOH B . 
F 3 HOH   33  1033 330 HOH   HOH B . 
F 3 HOH   34  1034 24  HOH   HOH B . 
F 3 HOH   35  1035 40  HOH   HOH B . 
F 3 HOH   36  1036 230 HOH   HOH B . 
F 3 HOH   37  1037 19  HOH   HOH B . 
F 3 HOH   38  1038 38  HOH   HOH B . 
F 3 HOH   39  1039 120 HOH   HOH B . 
F 3 HOH   40  1040 207 HOH   HOH B . 
F 3 HOH   41  1041 307 HOH   HOH B . 
F 3 HOH   42  1042 42  HOH   HOH B . 
F 3 HOH   43  1043 237 HOH   HOH B . 
F 3 HOH   44  1044 18  HOH   HOH B . 
F 3 HOH   45  1045 159 HOH   HOH B . 
F 3 HOH   46  1046 114 HOH   HOH B . 
F 3 HOH   47  1047 248 HOH   HOH B . 
F 3 HOH   48  1048 247 HOH   HOH B . 
F 3 HOH   49  1049 235 HOH   HOH B . 
F 3 HOH   50  1050 294 HOH   HOH B . 
F 3 HOH   51  1051 243 HOH   HOH B . 
F 3 HOH   52  1052 119 HOH   HOH B . 
F 3 HOH   53  1053 228 HOH   HOH B . 
F 3 HOH   54  1054 249 HOH   HOH B . 
F 3 HOH   55  1055 176 HOH   HOH B . 
F 3 HOH   56  1056 94  HOH   HOH B . 
F 3 HOH   57  1057 25  HOH   HOH B . 
F 3 HOH   58  1058 206 HOH   HOH B . 
F 3 HOH   59  1059 299 HOH   HOH B . 
F 3 HOH   60  1060 161 HOH   HOH B . 
F 3 HOH   61  1061 34  HOH   HOH B . 
F 3 HOH   62  1062 163 HOH   HOH B . 
F 3 HOH   63  1063 180 HOH   HOH B . 
F 3 HOH   64  1064 272 HOH   HOH B . 
F 3 HOH   65  1065 36  HOH   HOH B . 
F 3 HOH   66  1066 111 HOH   HOH B . 
F 3 HOH   67  1067 273 HOH   HOH B . 
F 3 HOH   68  1068 246 HOH   HOH B . 
F 3 HOH   69  1069 21  HOH   HOH B . 
F 3 HOH   70  1070 109 HOH   HOH B . 
F 3 HOH   71  1071 267 HOH   HOH B . 
F 3 HOH   72  1072 46  HOH   HOH B . 
F 3 HOH   73  1073 261 HOH   HOH B . 
F 3 HOH   74  1074 305 HOH   HOH B . 
F 3 HOH   75  1075 322 HOH   HOH B . 
F 3 HOH   76  1076 93  HOH   HOH B . 
F 3 HOH   77  1077 236 HOH   HOH B . 
F 3 HOH   78  1078 300 HOH   HOH B . 
F 3 HOH   79  1079 326 HOH   HOH B . 
F 3 HOH   80  1080 130 HOH   HOH B . 
F 3 HOH   81  1081 27  HOH   HOH B . 
F 3 HOH   82  1082 240 HOH   HOH B . 
F 3 HOH   83  1083 113 HOH   HOH B . 
F 3 HOH   84  1084 110 HOH   HOH B . 
F 3 HOH   85  1085 293 HOH   HOH B . 
F 3 HOH   86  1086 290 HOH   HOH B . 
F 3 HOH   87  1087 103 HOH   HOH B . 
F 3 HOH   88  1088 301 HOH   HOH B . 
F 3 HOH   89  1089 298 HOH   HOH B . 
F 3 HOH   90  1090 23  HOH   HOH B . 
F 3 HOH   91  1091 259 HOH   HOH B . 
F 3 HOH   92  1092 162 HOH   HOH B . 
F 3 HOH   93  1093 325 HOH   HOH B . 
F 3 HOH   94  1094 33  HOH   HOH B . 
F 3 HOH   95  1095 96  HOH   HOH B . 
F 3 HOH   96  1096 44  HOH   HOH B . 
F 3 HOH   97  1097 229 HOH   HOH B . 
F 3 HOH   98  1098 160 HOH   HOH B . 
F 3 HOH   99  1099 117 HOH   HOH B . 
F 3 HOH   100 1100 124 HOH   HOH B . 
F 3 HOH   101 1101 245 HOH   HOH B . 
F 3 HOH   102 1102 174 HOH   HOH B . 
F 3 HOH   103 1103 112 HOH   HOH B . 
F 3 HOH   104 1104 43  HOH   HOH B . 
F 3 HOH   105 1105 258 HOH   HOH B . 
F 3 HOH   106 1106 291 HOH   HOH B . 
F 3 HOH   107 1107 118 HOH   HOH B . 
F 3 HOH   108 1108 296 HOH   HOH B . 
F 3 HOH   109 1109 128 HOH   HOH B . 
F 3 HOH   110 1110 182 HOH   HOH B . 
F 3 HOH   111 1111 31  HOH   HOH B . 
F 3 HOH   112 1112 102 HOH   HOH B . 
F 3 HOH   113 1113 308 HOH   HOH B . 
F 3 HOH   114 1114 121 HOH   HOH B . 
F 3 HOH   115 1115 238 HOH   HOH B . 
F 3 HOH   116 1116 170 HOH   HOH B . 
F 3 HOH   117 1117 165 HOH   HOH B . 
F 3 HOH   118 1118 100 HOH   HOH B . 
F 3 HOH   119 1119 104 HOH   HOH B . 
F 3 HOH   120 1120 26  HOH   HOH B . 
F 3 HOH   121 1121 126 HOH   HOH B . 
F 3 HOH   122 1122 303 HOH   HOH B . 
F 3 HOH   123 1123 92  HOH   HOH B . 
F 3 HOH   124 1124 316 HOH   HOH B . 
F 3 HOH   125 1125 129 HOH   HOH B . 
F 3 HOH   126 1126 37  HOH   HOH B . 
F 3 HOH   127 1127 306 HOH   HOH B . 
F 3 HOH   128 1128 239 HOH   HOH B . 
F 3 HOH   129 1129 116 HOH   HOH B . 
F 3 HOH   130 1130 125 HOH   HOH B . 
F 3 HOH   131 1131 302 HOH   HOH B . 
F 3 HOH   132 1132 319 HOH   HOH B . 
F 3 HOH   133 1133 250 HOH   HOH B . 
F 3 HOH   134 1134 295 HOH   HOH B . 
F 3 HOH   135 1135 97  HOH   HOH B . 
F 3 HOH   136 1136 264 HOH   HOH B . 
F 3 HOH   137 1137 244 HOH   HOH B . 
F 3 HOH   138 1138 304 HOH   HOH B . 
F 3 HOH   139 1139 127 HOH   HOH B . 
F 3 HOH   140 1140 115 HOH   HOH B . 
F 3 HOH   141 1141 166 HOH   HOH B . 
F 3 HOH   142 1142 318 HOH   HOH B . 
F 3 HOH   143 1143 265 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.016 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XQ1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     39.632 
_cell.length_a_esd                 ? 
_cell.length_b                     85.152 
_cell.length_b_esd                 ? 
_cell.length_c                     89.506 
_cell.length_c_esd                 ? 
_cell.volume                       302059.830 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XQ1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XQ1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.23 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.78 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Bis-Tris pH 6.5, 20% PEG 1500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 315r' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2016-11-17 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9990 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 5C (4A)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9990 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '5C (4A)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          16.50 
_reflns.entry_id                                       8XQ1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.5 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     94767 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4.02 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.780 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.5 
_reflns_shell.d_res_low                                     1.53 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6259 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.780 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.96 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XQ1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.50 
_refine.ls_d_res_low                             42.58 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     94320 
_refine.ls_number_reflns_R_free                  4724 
_refine.ls_number_reflns_R_work                  89596 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.28 
_refine.ls_percent_reflns_R_free                 5.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1876 
_refine.ls_R_factor_R_free                       0.2091 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1864 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.50 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.9934 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1530 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.50 
_refine_hist.d_res_low                        42.58 
_refine_hist.number_atoms_solvent             295 
_refine_hist.number_atoms_total               4659 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4290 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         74 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0147  ? 4470 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4056  ? 6028 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0816  ? 626  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0118  ? 748  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.1794 ? 1676 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.50 1.52  . . 151 2997 98.19 . . . . 0.2399 . . . . . . . . . . . 0.2778 
'X-RAY DIFFRACTION' 1.52 1.53  . . 163 2921 98.50 . . . . 0.2228 . . . . . . . . . . . 0.2658 
'X-RAY DIFFRACTION' 1.53 1.55  . . 160 2942 98.63 . . . . 0.2225 . . . . . . . . . . . 0.2369 
'X-RAY DIFFRACTION' 1.55 1.57  . . 151 2995 99.09 . . . . 0.2063 . . . . . . . . . . . 0.2235 
'X-RAY DIFFRACTION' 1.57 1.59  . . 148 2991 98.77 . . . . 0.1938 . . . . . . . . . . . 0.2357 
'X-RAY DIFFRACTION' 1.59 1.62  . . 164 2935 99.17 . . . . 0.1926 . . . . . . . . . . . 0.2285 
'X-RAY DIFFRACTION' 1.62 1.64  . . 167 2976 99.40 . . . . 0.1874 . . . . . . . . . . . 0.2352 
'X-RAY DIFFRACTION' 1.64 1.66  . . 155 3003 99.46 . . . . 0.1838 . . . . . . . . . . . 0.2245 
'X-RAY DIFFRACTION' 1.66 1.69  . . 136 2962 99.36 . . . . 0.1855 . . . . . . . . . . . 0.2306 
'X-RAY DIFFRACTION' 1.69 1.72  . . 157 2994 99.18 . . . . 0.1783 . . . . . . . . . . . 0.2187 
'X-RAY DIFFRACTION' 1.72 1.75  . . 145 2982 99.78 . . . . 0.1759 . . . . . . . . . . . 0.2192 
'X-RAY DIFFRACTION' 1.75 1.78  . . 148 2999 99.56 . . . . 0.1792 . . . . . . . . . . . 0.1951 
'X-RAY DIFFRACTION' 1.78 1.81  . . 162 3020 99.66 . . . . 0.1792 . . . . . . . . . . . 0.2503 
'X-RAY DIFFRACTION' 1.81 1.85  . . 149 2948 99.65 . . . . 0.1855 . . . . . . . . . . . 0.2338 
'X-RAY DIFFRACTION' 1.85 1.89  . . 149 3016 99.53 . . . . 0.1800 . . . . . . . . . . . 0.2175 
'X-RAY DIFFRACTION' 1.89 1.93  . . 155 2974 99.81 . . . . 0.1858 . . . . . . . . . . . 0.1948 
'X-RAY DIFFRACTION' 1.93 1.98  . . 155 3038 99.84 . . . . 0.1847 . . . . . . . . . . . 0.2153 
'X-RAY DIFFRACTION' 1.98 2.04  . . 153 2969 99.87 . . . . 0.1793 . . . . . . . . . . . 0.2090 
'X-RAY DIFFRACTION' 2.04 2.10  . . 166 3029 99.81 . . . . 0.1832 . . . . . . . . . . . 0.2103 
'X-RAY DIFFRACTION' 2.10 2.16  . . 145 2973 99.90 . . . . 0.1829 . . . . . . . . . . . 0.2257 
'X-RAY DIFFRACTION' 2.16 2.24  . . 172 3003 99.94 . . . . 0.1807 . . . . . . . . . . . 0.2188 
'X-RAY DIFFRACTION' 2.24 2.33  . . 177 3034 99.84 . . . . 0.1824 . . . . . . . . . . . 0.2046 
'X-RAY DIFFRACTION' 2.33 2.44  . . 135 2970 99.90 . . . . 0.1846 . . . . . . . . . . . 0.1942 
'X-RAY DIFFRACTION' 2.44 2.56  . . 156 3001 99.78 . . . . 0.1866 . . . . . . . . . . . 0.2163 
'X-RAY DIFFRACTION' 2.56 2.73  . . 153 3027 99.87 . . . . 0.1896 . . . . . . . . . . . 0.2354 
'X-RAY DIFFRACTION' 2.73 2.94  . . 161 3020 99.94 . . . . 0.1974 . . . . . . . . . . . 0.2269 
'X-RAY DIFFRACTION' 2.94 3.23  . . 189 2986 99.84 . . . . 0.1984 . . . . . . . . . . . 0.2033 
'X-RAY DIFFRACTION' 3.23 3.70  . . 142 2998 99.21 . . . . 0.1919 . . . . . . . . . . . 0.2178 
'X-RAY DIFFRACTION' 3.70 4.66  . . 180 2958 97.73 . . . . 0.1658 . . . . . . . . . . . 0.1696 
'X-RAY DIFFRACTION' 4.66 42.58 . . 180 2935 95.55 . . . . 0.1874 . . . . . . . . . . . 0.1920 
# 
_struct.entry_id                     8XQ1 
_struct.title                        'Crystal structure of spleen tyrosine kinase(SYK) in complex with SKI-G-1673' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XQ1 
_struct_keywords.text            'SIGNALING PROTEIN-INHIBITOR COMPLEX, SIGNALING PROTEIN-INHIBITOR' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN-INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KSYK_HUMAN 
_struct_ref.pdbx_db_accession          P43405 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM
IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL
SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA
GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
;
_struct_ref.pdbx_align_begin           356 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XQ1 A 1 ? 280 ? P43405 356 ? 635 ? 356 635 
2 1 8XQ1 B 1 ? 280 ? P43405 356 ? 635 ? 356 635 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8XQ1 LEU A 281 ? UNP P43405 ? ? 'expression tag' 636 1  
1 8XQ1 GLU A 282 ? UNP P43405 ? ? 'expression tag' 637 2  
1 8XQ1 HIS A 283 ? UNP P43405 ? ? 'expression tag' 638 3  
1 8XQ1 HIS A 284 ? UNP P43405 ? ? 'expression tag' 639 4  
1 8XQ1 HIS A 285 ? UNP P43405 ? ? 'expression tag' 640 5  
1 8XQ1 HIS A 286 ? UNP P43405 ? ? 'expression tag' 641 6  
1 8XQ1 HIS A 287 ? UNP P43405 ? ? 'expression tag' 642 7  
1 8XQ1 HIS A 288 ? UNP P43405 ? ? 'expression tag' 643 8  
1 8XQ1 HIS A 289 ? UNP P43405 ? ? 'expression tag' 644 9  
1 8XQ1 HIS A 290 ? UNP P43405 ? ? 'expression tag' 645 10 
2 8XQ1 LEU B 281 ? UNP P43405 ? ? 'expression tag' 636 11 
2 8XQ1 GLU B 282 ? UNP P43405 ? ? 'expression tag' 637 12 
2 8XQ1 HIS B 283 ? UNP P43405 ? ? 'expression tag' 638 13 
2 8XQ1 HIS B 284 ? UNP P43405 ? ? 'expression tag' 639 14 
2 8XQ1 HIS B 285 ? UNP P43405 ? ? 'expression tag' 640 15 
2 8XQ1 HIS B 286 ? UNP P43405 ? ? 'expression tag' 641 16 
2 8XQ1 HIS B 287 ? UNP P43405 ? ? 'expression tag' 642 17 
2 8XQ1 HIS B 288 ? UNP P43405 ? ? 'expression tag' 643 18 
2 8XQ1 HIS B 289 ? UNP P43405 ? ? 'expression tag' 644 19 
2 8XQ1 HIS B 290 ? UNP P43405 ? ? 'expression tag' 645 20 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                Monomer 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 11  ? LYS A 13  ? ASP A 366 LYS A 368 5 ? 3  
HELX_P HELX_P2  AA2 ALA A 57  ? GLN A 71  ? ALA A 412 GLN A 426 1 ? 15 
HELX_P HELX_P3  AA3 LEU A 101 ? ASN A 108 ? LEU A 456 ASN A 463 1 ? 8  
HELX_P HELX_P4  AA4 LYS A 112 ? SER A 133 ? LYS A 467 SER A 488 1 ? 22 
HELX_P HELX_P5  AA5 ALA A 141 ? ARG A 143 ? ALA A 496 ARG A 498 5 ? 3  
HELX_P HELX_P6  AA6 PRO A 180 ? TYR A 184 ? PRO A 535 TYR A 539 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 185 ? TYR A 192 ? ALA A 540 TYR A 547 1 ? 8  
HELX_P HELX_P8  AA8 SER A 195 ? SER A 212 ? SER A 550 SER A 567 1 ? 18 
HELX_P HELX_P9  AA9 LYS A 222 ? LYS A 232 ? LYS A 577 LYS A 587 1 ? 11 
HELX_P HELX_P10 AB1 PRO A 243 ? TRP A 254 ? PRO A 598 TRP A 609 1 ? 12 
HELX_P HELX_P11 AB2 ASP A 257 ? ARG A 261 ? ASP A 612 ARG A 616 5 ? 5  
HELX_P HELX_P12 AB3 GLY A 263 ? VAL A 279 ? GLY A 618 VAL A 634 1 ? 17 
HELX_P HELX_P13 AB4 ASP B 11  ? LYS B 13  ? ASP B 366 LYS B 368 5 ? 3  
HELX_P HELX_P14 AB5 ALA B 57  ? GLN B 71  ? ALA B 412 GLN B 426 1 ? 15 
HELX_P HELX_P15 AB6 LEU B 101 ? ASN B 108 ? LEU B 456 ASN B 463 1 ? 8  
HELX_P HELX_P16 AB7 LYS B 112 ? SER B 133 ? LYS B 467 SER B 488 1 ? 22 
HELX_P HELX_P17 AB8 ALA B 141 ? ARG B 143 ? ALA B 496 ARG B 498 5 ? 3  
HELX_P HELX_P18 AB9 PRO B 180 ? TYR B 184 ? PRO B 535 TYR B 539 5 ? 5  
HELX_P HELX_P19 AC1 ALA B 185 ? TYR B 192 ? ALA B 540 TYR B 547 1 ? 8  
HELX_P HELX_P20 AC2 SER B 195 ? SER B 212 ? SER B 550 SER B 567 1 ? 18 
HELX_P HELX_P21 AC3 LYS B 222 ? LYS B 232 ? LYS B 577 LYS B 587 1 ? 11 
HELX_P HELX_P22 AC4 PRO B 243 ? TRP B 254 ? PRO B 598 TRP B 609 1 ? 12 
HELX_P HELX_P23 AC5 ASP B 257 ? ARG B 261 ? ASP B 612 ARG B 616 5 ? 5  
HELX_P HELX_P24 AC6 GLY B 263 ? VAL B 279 ? GLY B 618 VAL B 634 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
AA7 ? 5 ? 
AA8 ? 3 ? 
AA9 ? 2 ? 
AB1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AB1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 15  ? LEU A 17  ? LEU A 370 LEU A 372 
AA1 2 GLY A 28  ? GLN A 36  ? GLY A 383 GLN A 391 
AA1 3 GLY A 23  ? GLY A 25  ? GLY A 378 GLY A 380 
AA2 1 LEU A 15  ? LEU A 17  ? LEU A 370 LEU A 372 
AA2 2 GLY A 28  ? GLN A 36  ? GLY A 383 GLN A 391 
AA2 3 VAL A 41  ? ILE A 48  ? VAL A 396 ILE A 403 
AA2 4 TRP A 89  ? GLU A 94  ? TRP A 444 GLU A 449 
AA2 5 MET A 80  ? GLU A 85  ? MET A 435 GLU A 440 
AA3 1 GLY A 99  ? PRO A 100 ? GLY A 454 PRO A 455 
AA3 2 VAL A 145 ? THR A 149 ? VAL A 500 THR A 504 
AA3 3 TYR A 152 ? ILE A 155 ? TYR A 507 ILE A 510 
AA4 1 PHE A 135 ? VAL A 136 ? PHE A 490 VAL A 491 
AA4 2 LYS A 162 ? ALA A 163 ? LYS A 517 ALA A 518 
AA5 1 TYR A 171 ? LYS A 172 ? TYR A 526 LYS A 527 
AA5 2 LYS A 193 ? PHE A 194 ? LYS A 548 PHE A 549 
AA6 1 LEU B 15  ? LEU B 17  ? LEU B 370 LEU B 372 
AA6 2 GLY B 28  ? GLN B 36  ? GLY B 383 GLN B 391 
AA6 3 GLY B 23  ? GLY B 25  ? GLY B 378 GLY B 380 
AA7 1 LEU B 15  ? LEU B 17  ? LEU B 370 LEU B 372 
AA7 2 GLY B 28  ? GLN B 36  ? GLY B 383 GLN B 391 
AA7 3 VAL B 41  ? LEU B 49  ? VAL B 396 LEU B 404 
AA7 4 TRP B 89  ? GLU B 94  ? TRP B 444 GLU B 449 
AA7 5 MET B 80  ? GLU B 85  ? MET B 435 GLU B 440 
AA8 1 GLY B 99  ? PRO B 100 ? GLY B 454 PRO B 455 
AA8 2 VAL B 145 ? THR B 149 ? VAL B 500 THR B 504 
AA8 3 TYR B 152 ? ILE B 155 ? TYR B 507 ILE B 510 
AA9 1 PHE B 135 ? VAL B 136 ? PHE B 490 VAL B 491 
AA9 2 LYS B 162 ? ALA B 163 ? LYS B 517 ALA B 518 
AB1 1 TYR B 171 ? LYS B 172 ? TYR B 526 LYS B 527 
AB1 2 LYS B 193 ? PHE B 194 ? LYS B 548 PHE B 549 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 16  ? N THR A 371 O TYR A 34  ? O TYR A 389 
AA1 2 3 O VAL A 30  ? O VAL A 385 N GLY A 23  ? N GLY A 378 
AA2 1 2 N THR A 16  ? N THR A 371 O TYR A 34  ? O TYR A 389 
AA2 2 3 N THR A 29  ? N THR A 384 O ILE A 48  ? O ILE A 403 
AA2 3 4 N LYS A 47  ? N LYS A 402 O LEU A 91  ? O LEU A 446 
AA2 4 5 O VAL A 92  ? O VAL A 447 N ILE A 81  ? N ILE A 436 
AA3 1 2 N GLY A 99  ? N GLY A 454 O LEU A 147 ? O LEU A 502 
AA3 2 3 N LEU A 146 ? N LEU A 501 O LYS A 154 ? O LYS A 509 
AA4 1 2 N VAL A 136 ? N VAL A 491 O LYS A 162 ? O LYS A 517 
AA5 1 2 N TYR A 171 ? N TYR A 526 O PHE A 194 ? O PHE A 549 
AA6 1 2 N THR B 16  ? N THR B 371 O TYR B 34  ? O TYR B 389 
AA6 2 3 O GLY B 28  ? O GLY B 383 N GLY B 25  ? N GLY B 380 
AA7 1 2 N THR B 16  ? N THR B 371 O TYR B 34  ? O TYR B 389 
AA7 2 3 N THR B 29  ? N THR B 384 O ILE B 48  ? O ILE B 403 
AA7 3 4 N LYS B 47  ? N LYS B 402 O LEU B 91  ? O LEU B 446 
AA7 4 5 O VAL B 92  ? O VAL B 447 N ILE B 81  ? N ILE B 436 
AA8 1 2 N GLY B 99  ? N GLY B 454 O LEU B 147 ? O LEU B 502 
AA8 2 3 N VAL B 148 ? N VAL B 503 O TYR B 152 ? O TYR B 507 
AA9 1 2 N VAL B 136 ? N VAL B 491 O LYS B 162 ? O LYS B 517 
AB1 1 2 N TYR B 171 ? N TYR B 526 O PHE B 194 ? O PHE B 549 
# 
_pdbx_entry_details.entry_id                   8XQ1 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CG A MET 435 ? ? SD A MET 435 ? ? CE  A MET 435 ? ? 88.57  100.20 -11.63 1.60 N 
2 1 CB B ASP 554 ? ? CG B ASP 554 ? ? OD2 B ASP 554 ? ? 112.69 118.30 -5.61  0.90 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 394 ? ? -126.34 -55.25  
2  1 ALA A 441 ? ? -138.55 -129.37 
3  1 ASP A 494 ? ? -150.59 47.12   
4  1 ASP A 512 ? ? 66.63   71.35   
5  1 TRP A 609 ? ? -90.39  37.10   
6  1 LYS B 394 ? ? -136.89 -52.38  
7  1 ALA B 441 ? ? -137.50 -129.13 
8  1 ASP B 494 ? ? -152.57 44.85   
9  1 ASP B 512 ? ? 66.54   73.25   
10 1 TRP B 609 ? ? -90.29  36.78   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLU 356 ? A GLU 1   
2  1 Y 1 A GLU 357 ? A GLU 2   
3  1 Y 1 A ILE 358 ? A ILE 3   
4  1 Y 1 A ARG 359 ? A ARG 4   
5  1 Y 1 A PRO 360 ? A PRO 5   
6  1 Y 1 A LYS 361 ? A LYS 6   
7  1 Y 1 A GLU 362 ? A GLU 7   
8  1 Y 1 A VAL 363 ? A VAL 8   
9  1 Y 1 A ASN 406 ? A ASN 51  
10 1 Y 1 A GLU 407 ? A GLU 52  
11 1 Y 1 A ALA 408 ? A ALA 53  
12 1 Y 1 A ASN 409 ? A ASN 54  
13 1 Y 1 A ASP 410 ? A ASP 55  
14 1 Y 1 A THR 530 ? A THR 175 
15 1 Y 1 A HIS 531 ? A HIS 176 
16 1 Y 1 A GLY 532 ? A GLY 177 
17 1 Y 1 A ASN 635 ? A ASN 280 
18 1 Y 1 A LEU 636 ? A LEU 281 
19 1 Y 1 A GLU 637 ? A GLU 282 
20 1 Y 1 A HIS 638 ? A HIS 283 
21 1 Y 1 A HIS 639 ? A HIS 284 
22 1 Y 1 A HIS 640 ? A HIS 285 
23 1 Y 1 A HIS 641 ? A HIS 286 
24 1 Y 1 A HIS 642 ? A HIS 287 
25 1 Y 1 A HIS 643 ? A HIS 288 
26 1 Y 1 A HIS 644 ? A HIS 289 
27 1 Y 1 A HIS 645 ? A HIS 290 
28 1 Y 1 B GLU 356 ? B GLU 1   
29 1 Y 1 B GLU 357 ? B GLU 2   
30 1 Y 1 B ILE 358 ? B ILE 3   
31 1 Y 1 B ARG 359 ? B ARG 4   
32 1 Y 1 B PRO 360 ? B PRO 5   
33 1 Y 1 B LYS 361 ? B LYS 6   
34 1 Y 1 B GLU 362 ? B GLU 7   
35 1 Y 1 B VAL 363 ? B VAL 8   
36 1 Y 1 B ASN 406 ? B ASN 51  
37 1 Y 1 B GLU 407 ? B GLU 52  
38 1 Y 1 B ALA 408 ? B ALA 53  
39 1 Y 1 B ASN 409 ? B ASN 54  
40 1 Y 1 B ASP 410 ? B ASP 55  
41 1 Y 1 B THR 530 ? B THR 175 
42 1 Y 1 B HIS 531 ? B HIS 176 
43 1 Y 1 B GLY 532 ? B GLY 177 
44 1 Y 1 B ASN 635 ? B ASN 280 
45 1 Y 1 B LEU 636 ? B LEU 281 
46 1 Y 1 B GLU 637 ? B GLU 282 
47 1 Y 1 B HIS 638 ? B HIS 283 
48 1 Y 1 B HIS 639 ? B HIS 284 
49 1 Y 1 B HIS 640 ? B HIS 285 
50 1 Y 1 B HIS 641 ? B HIS 286 
51 1 Y 1 B HIS 642 ? B HIS 287 
52 1 Y 1 B HIS 643 ? B HIS 288 
53 1 Y 1 B HIS 644 ? B HIS 289 
54 1 Y 1 B HIS 645 ? B HIS 290 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LV6 N1   N Y N 1   
A1LV6 N3   N N N 2   
A1LV6 C4   C Y N 3   
A1LV6 C5   C Y N 4   
A1LV6 C6   C Y N 5   
A1LV6 C7   C Y N 6   
A1LV6 C8   C Y N 7   
A1LV6 C10  C Y N 8   
A1LV6 C13  C N N 9   
A1LV6 C15  C N N 10  
A1LV6 C17  C Y N 11  
A1LV6 C20  C N N 12  
A1LV6 C21  C N N 13  
A1LV6 C22  C N N 14  
A1LV6 C24  C N S 15  
A1LV6 C26  C N N 16  
A1LV6 C1   C Y N 17  
A1LV6 C11  C Y N 18  
A1LV6 C12  C N N 19  
A1LV6 C14  C N N 20  
A1LV6 C16  C N N 21  
A1LV6 C18  C Y N 22  
A1LV6 C19  C Y N 23  
A1LV6 C2   C Y N 24  
A1LV6 C23  C N R 25  
A1LV6 C25  C N N 26  
A1LV6 C3   C Y N 27  
A1LV6 C9   C Y N 28  
A1LV6 N2   N Y N 29  
A1LV6 N4   N Y N 30  
A1LV6 N5   N Y N 31  
A1LV6 N6   N Y N 32  
A1LV6 N7   N Y N 33  
A1LV6 N8   N N N 34  
A1LV6 O1   O N N 35  
A1LV6 O2   O N N 36  
A1LV6 O3   O N N 37  
A1LV6 H1   H N N 38  
A1LV6 H2   H N N 39  
A1LV6 H3   H N N 40  
A1LV6 H4   H N N 41  
A1LV6 H5   H N N 42  
A1LV6 H6   H N N 43  
A1LV6 H7   H N N 44  
A1LV6 H8   H N N 45  
A1LV6 H9   H N N 46  
A1LV6 H10  H N N 47  
A1LV6 H11  H N N 48  
A1LV6 H12  H N N 49  
A1LV6 H13  H N N 50  
A1LV6 H14  H N N 51  
A1LV6 H15  H N N 52  
A1LV6 H16  H N N 53  
A1LV6 H17  H N N 54  
A1LV6 H18  H N N 55  
A1LV6 H19  H N N 56  
A1LV6 H20  H N N 57  
A1LV6 H21  H N N 58  
A1LV6 H22  H N N 59  
A1LV6 H23  H N N 60  
A1LV6 H24  H N N 61  
A1LV6 H25  H N N 62  
A1LV6 H26  H N N 63  
A1LV6 H27  H N N 64  
A1LV6 H28  H N N 65  
A1LV6 H29  H N N 66  
A1LV6 H31  H N N 67  
ALA   N    N N N 68  
ALA   CA   C N S 69  
ALA   C    C N N 70  
ALA   O    O N N 71  
ALA   CB   C N N 72  
ALA   OXT  O N N 73  
ALA   H    H N N 74  
ALA   H2   H N N 75  
ALA   HA   H N N 76  
ALA   HB1  H N N 77  
ALA   HB2  H N N 78  
ALA   HB3  H N N 79  
ALA   HXT  H N N 80  
ARG   N    N N N 81  
ARG   CA   C N S 82  
ARG   C    C N N 83  
ARG   O    O N N 84  
ARG   CB   C N N 85  
ARG   CG   C N N 86  
ARG   CD   C N N 87  
ARG   NE   N N N 88  
ARG   CZ   C N N 89  
ARG   NH1  N N N 90  
ARG   NH2  N N N 91  
ARG   OXT  O N N 92  
ARG   H    H N N 93  
ARG   H2   H N N 94  
ARG   HA   H N N 95  
ARG   HB2  H N N 96  
ARG   HB3  H N N 97  
ARG   HG2  H N N 98  
ARG   HG3  H N N 99  
ARG   HD2  H N N 100 
ARG   HD3  H N N 101 
ARG   HE   H N N 102 
ARG   HH11 H N N 103 
ARG   HH12 H N N 104 
ARG   HH21 H N N 105 
ARG   HH22 H N N 106 
ARG   HXT  H N N 107 
ASN   N    N N N 108 
ASN   CA   C N S 109 
ASN   C    C N N 110 
ASN   O    O N N 111 
ASN   CB   C N N 112 
ASN   CG   C N N 113 
ASN   OD1  O N N 114 
ASN   ND2  N N N 115 
ASN   OXT  O N N 116 
ASN   H    H N N 117 
ASN   H2   H N N 118 
ASN   HA   H N N 119 
ASN   HB2  H N N 120 
ASN   HB3  H N N 121 
ASN   HD21 H N N 122 
ASN   HD22 H N N 123 
ASN   HXT  H N N 124 
ASP   N    N N N 125 
ASP   CA   C N S 126 
ASP   C    C N N 127 
ASP   O    O N N 128 
ASP   CB   C N N 129 
ASP   CG   C N N 130 
ASP   OD1  O N N 131 
ASP   OD2  O N N 132 
ASP   OXT  O N N 133 
ASP   H    H N N 134 
ASP   H2   H N N 135 
ASP   HA   H N N 136 
ASP   HB2  H N N 137 
ASP   HB3  H N N 138 
ASP   HD2  H N N 139 
ASP   HXT  H N N 140 
CYS   N    N N N 141 
CYS   CA   C N R 142 
CYS   C    C N N 143 
CYS   O    O N N 144 
CYS   CB   C N N 145 
CYS   SG   S N N 146 
CYS   OXT  O N N 147 
CYS   H    H N N 148 
CYS   H2   H N N 149 
CYS   HA   H N N 150 
CYS   HB2  H N N 151 
CYS   HB3  H N N 152 
CYS   HG   H N N 153 
CYS   HXT  H N N 154 
GLN   N    N N N 155 
GLN   CA   C N S 156 
GLN   C    C N N 157 
GLN   O    O N N 158 
GLN   CB   C N N 159 
GLN   CG   C N N 160 
GLN   CD   C N N 161 
GLN   OE1  O N N 162 
GLN   NE2  N N N 163 
GLN   OXT  O N N 164 
GLN   H    H N N 165 
GLN   H2   H N N 166 
GLN   HA   H N N 167 
GLN   HB2  H N N 168 
GLN   HB3  H N N 169 
GLN   HG2  H N N 170 
GLN   HG3  H N N 171 
GLN   HE21 H N N 172 
GLN   HE22 H N N 173 
GLN   HXT  H N N 174 
GLU   N    N N N 175 
GLU   CA   C N S 176 
GLU   C    C N N 177 
GLU   O    O N N 178 
GLU   CB   C N N 179 
GLU   CG   C N N 180 
GLU   CD   C N N 181 
GLU   OE1  O N N 182 
GLU   OE2  O N N 183 
GLU   OXT  O N N 184 
GLU   H    H N N 185 
GLU   H2   H N N 186 
GLU   HA   H N N 187 
GLU   HB2  H N N 188 
GLU   HB3  H N N 189 
GLU   HG2  H N N 190 
GLU   HG3  H N N 191 
GLU   HE2  H N N 192 
GLU   HXT  H N N 193 
GLY   N    N N N 194 
GLY   CA   C N N 195 
GLY   C    C N N 196 
GLY   O    O N N 197 
GLY   OXT  O N N 198 
GLY   H    H N N 199 
GLY   H2   H N N 200 
GLY   HA2  H N N 201 
GLY   HA3  H N N 202 
GLY   HXT  H N N 203 
HIS   N    N N N 204 
HIS   CA   C N S 205 
HIS   C    C N N 206 
HIS   O    O N N 207 
HIS   CB   C N N 208 
HIS   CG   C Y N 209 
HIS   ND1  N Y N 210 
HIS   CD2  C Y N 211 
HIS   CE1  C Y N 212 
HIS   NE2  N Y N 213 
HIS   OXT  O N N 214 
HIS   H    H N N 215 
HIS   H2   H N N 216 
HIS   HA   H N N 217 
HIS   HB2  H N N 218 
HIS   HB3  H N N 219 
HIS   HD1  H N N 220 
HIS   HD2  H N N 221 
HIS   HE1  H N N 222 
HIS   HE2  H N N 223 
HIS   HXT  H N N 224 
HOH   O    O N N 225 
HOH   H1   H N N 226 
HOH   H2   H N N 227 
ILE   N    N N N 228 
ILE   CA   C N S 229 
ILE   C    C N N 230 
ILE   O    O N N 231 
ILE   CB   C N S 232 
ILE   CG1  C N N 233 
ILE   CG2  C N N 234 
ILE   CD1  C N N 235 
ILE   OXT  O N N 236 
ILE   H    H N N 237 
ILE   H2   H N N 238 
ILE   HA   H N N 239 
ILE   HB   H N N 240 
ILE   HG12 H N N 241 
ILE   HG13 H N N 242 
ILE   HG21 H N N 243 
ILE   HG22 H N N 244 
ILE   HG23 H N N 245 
ILE   HD11 H N N 246 
ILE   HD12 H N N 247 
ILE   HD13 H N N 248 
ILE   HXT  H N N 249 
LEU   N    N N N 250 
LEU   CA   C N S 251 
LEU   C    C N N 252 
LEU   O    O N N 253 
LEU   CB   C N N 254 
LEU   CG   C N N 255 
LEU   CD1  C N N 256 
LEU   CD2  C N N 257 
LEU   OXT  O N N 258 
LEU   H    H N N 259 
LEU   H2   H N N 260 
LEU   HA   H N N 261 
LEU   HB2  H N N 262 
LEU   HB3  H N N 263 
LEU   HG   H N N 264 
LEU   HD11 H N N 265 
LEU   HD12 H N N 266 
LEU   HD13 H N N 267 
LEU   HD21 H N N 268 
LEU   HD22 H N N 269 
LEU   HD23 H N N 270 
LEU   HXT  H N N 271 
LYS   N    N N N 272 
LYS   CA   C N S 273 
LYS   C    C N N 274 
LYS   O    O N N 275 
LYS   CB   C N N 276 
LYS   CG   C N N 277 
LYS   CD   C N N 278 
LYS   CE   C N N 279 
LYS   NZ   N N N 280 
LYS   OXT  O N N 281 
LYS   H    H N N 282 
LYS   H2   H N N 283 
LYS   HA   H N N 284 
LYS   HB2  H N N 285 
LYS   HB3  H N N 286 
LYS   HG2  H N N 287 
LYS   HG3  H N N 288 
LYS   HD2  H N N 289 
LYS   HD3  H N N 290 
LYS   HE2  H N N 291 
LYS   HE3  H N N 292 
LYS   HZ1  H N N 293 
LYS   HZ2  H N N 294 
LYS   HZ3  H N N 295 
LYS   HXT  H N N 296 
MET   N    N N N 297 
MET   CA   C N S 298 
MET   C    C N N 299 
MET   O    O N N 300 
MET   CB   C N N 301 
MET   CG   C N N 302 
MET   SD   S N N 303 
MET   CE   C N N 304 
MET   OXT  O N N 305 
MET   H    H N N 306 
MET   H2   H N N 307 
MET   HA   H N N 308 
MET   HB2  H N N 309 
MET   HB3  H N N 310 
MET   HG2  H N N 311 
MET   HG3  H N N 312 
MET   HE1  H N N 313 
MET   HE2  H N N 314 
MET   HE3  H N N 315 
MET   HXT  H N N 316 
PHE   N    N N N 317 
PHE   CA   C N S 318 
PHE   C    C N N 319 
PHE   O    O N N 320 
PHE   CB   C N N 321 
PHE   CG   C Y N 322 
PHE   CD1  C Y N 323 
PHE   CD2  C Y N 324 
PHE   CE1  C Y N 325 
PHE   CE2  C Y N 326 
PHE   CZ   C Y N 327 
PHE   OXT  O N N 328 
PHE   H    H N N 329 
PHE   H2   H N N 330 
PHE   HA   H N N 331 
PHE   HB2  H N N 332 
PHE   HB3  H N N 333 
PHE   HD1  H N N 334 
PHE   HD2  H N N 335 
PHE   HE1  H N N 336 
PHE   HE2  H N N 337 
PHE   HZ   H N N 338 
PHE   HXT  H N N 339 
PRO   N    N N N 340 
PRO   CA   C N S 341 
PRO   C    C N N 342 
PRO   O    O N N 343 
PRO   CB   C N N 344 
PRO   CG   C N N 345 
PRO   CD   C N N 346 
PRO   OXT  O N N 347 
PRO   H    H N N 348 
PRO   HA   H N N 349 
PRO   HB2  H N N 350 
PRO   HB3  H N N 351 
PRO   HG2  H N N 352 
PRO   HG3  H N N 353 
PRO   HD2  H N N 354 
PRO   HD3  H N N 355 
PRO   HXT  H N N 356 
SER   N    N N N 357 
SER   CA   C N S 358 
SER   C    C N N 359 
SER   O    O N N 360 
SER   CB   C N N 361 
SER   OG   O N N 362 
SER   OXT  O N N 363 
SER   H    H N N 364 
SER   H2   H N N 365 
SER   HA   H N N 366 
SER   HB2  H N N 367 
SER   HB3  H N N 368 
SER   HG   H N N 369 
SER   HXT  H N N 370 
THR   N    N N N 371 
THR   CA   C N S 372 
THR   C    C N N 373 
THR   O    O N N 374 
THR   CB   C N R 375 
THR   OG1  O N N 376 
THR   CG2  C N N 377 
THR   OXT  O N N 378 
THR   H    H N N 379 
THR   H2   H N N 380 
THR   HA   H N N 381 
THR   HB   H N N 382 
THR   HG1  H N N 383 
THR   HG21 H N N 384 
THR   HG22 H N N 385 
THR   HG23 H N N 386 
THR   HXT  H N N 387 
TRP   N    N N N 388 
TRP   CA   C N S 389 
TRP   C    C N N 390 
TRP   O    O N N 391 
TRP   CB   C N N 392 
TRP   CG   C Y N 393 
TRP   CD1  C Y N 394 
TRP   CD2  C Y N 395 
TRP   NE1  N Y N 396 
TRP   CE2  C Y N 397 
TRP   CE3  C Y N 398 
TRP   CZ2  C Y N 399 
TRP   CZ3  C Y N 400 
TRP   CH2  C Y N 401 
TRP   OXT  O N N 402 
TRP   H    H N N 403 
TRP   H2   H N N 404 
TRP   HA   H N N 405 
TRP   HB2  H N N 406 
TRP   HB3  H N N 407 
TRP   HD1  H N N 408 
TRP   HE1  H N N 409 
TRP   HE3  H N N 410 
TRP   HZ2  H N N 411 
TRP   HZ3  H N N 412 
TRP   HH2  H N N 413 
TRP   HXT  H N N 414 
TYR   N    N N N 415 
TYR   CA   C N S 416 
TYR   C    C N N 417 
TYR   O    O N N 418 
TYR   CB   C N N 419 
TYR   CG   C Y N 420 
TYR   CD1  C Y N 421 
TYR   CD2  C Y N 422 
TYR   CE1  C Y N 423 
TYR   CE2  C Y N 424 
TYR   CZ   C Y N 425 
TYR   OH   O N N 426 
TYR   OXT  O N N 427 
TYR   H    H N N 428 
TYR   H2   H N N 429 
TYR   HA   H N N 430 
TYR   HB2  H N N 431 
TYR   HB3  H N N 432 
TYR   HD1  H N N 433 
TYR   HD2  H N N 434 
TYR   HE1  H N N 435 
TYR   HE2  H N N 436 
TYR   HH   H N N 437 
TYR   HXT  H N N 438 
VAL   N    N N N 439 
VAL   CA   C N S 440 
VAL   C    C N N 441 
VAL   O    O N N 442 
VAL   CB   C N N 443 
VAL   CG1  C N N 444 
VAL   CG2  C N N 445 
VAL   OXT  O N N 446 
VAL   H    H N N 447 
VAL   H2   H N N 448 
VAL   HA   H N N 449 
VAL   HB   H N N 450 
VAL   HG11 H N N 451 
VAL   HG12 H N N 452 
VAL   HG13 H N N 453 
VAL   HG21 H N N 454 
VAL   HG22 H N N 455 
VAL   HG23 H N N 456 
VAL   HXT  H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LV6 N1  C1   doub Y N 1   
A1LV6 N1  C4   sing Y N 2   
A1LV6 C1  C2   sing Y N 3   
A1LV6 C1  N6   sing N N 4   
A1LV6 C2  C3   doub Y N 5   
A1LV6 C3  N2   sing Y N 6   
A1LV6 N2  C4   doub Y N 7   
A1LV6 C4  N3   sing N N 8   
A1LV6 N3  C5   sing N N 9   
A1LV6 C5  C6   doub Y N 10  
A1LV6 C5  C9   sing Y N 11  
A1LV6 C6  C7   sing Y N 12  
A1LV6 C7  C8   doub Y N 13  
A1LV6 C7  C11  sing Y N 14  
A1LV6 C8  N4   sing Y N 15  
A1LV6 C8  N5   sing Y N 16  
A1LV6 N4  C9   doub Y N 17  
A1LV6 N5  C10  sing Y N 18  
A1LV6 N5  C12  sing N N 19  
A1LV6 C10 C11  doub Y N 20  
A1LV6 C11 C13  sing N N 21  
A1LV6 C13 C14  sing N N 22  
A1LV6 C13 O1   doub N N 23  
A1LV6 C14 C15  sing N N 24  
A1LV6 C14 C16  sing N N 25  
A1LV6 C15 C16  sing N N 26  
A1LV6 N6  C17  sing Y N 27  
A1LV6 N6  N7   sing Y N 28  
A1LV6 C17 C18  doub Y N 29  
A1LV6 C18 C19  sing Y N 30  
A1LV6 C18 C21  sing N N 31  
A1LV6 C19 N7   doub Y N 32  
A1LV6 C19 C20  sing N N 33  
A1LV6 C21 N8   sing N N 34  
A1LV6 N8  C22  sing N N 35  
A1LV6 N8  C25  sing N N 36  
A1LV6 C22 C23  sing N N 37  
A1LV6 C23 C24  sing N N 38  
A1LV6 C23 O3   sing N N 39  
A1LV6 C24 C25  sing N N 40  
A1LV6 C24 O2   sing N N 41  
A1LV6 O3  C26  sing N N 42  
A1LV6 N3  H1   sing N N 43  
A1LV6 C6  H2   sing N N 44  
A1LV6 C10 H3   sing N N 45  
A1LV6 C15 H4   sing N N 46  
A1LV6 C15 H5   sing N N 47  
A1LV6 C17 H6   sing N N 48  
A1LV6 C20 H7   sing N N 49  
A1LV6 C20 H8   sing N N 50  
A1LV6 C20 H9   sing N N 51  
A1LV6 C21 H10  sing N N 52  
A1LV6 C21 H11  sing N N 53  
A1LV6 C22 H12  sing N N 54  
A1LV6 C22 H13  sing N N 55  
A1LV6 C24 H14  sing N N 56  
A1LV6 C26 H15  sing N N 57  
A1LV6 C26 H16  sing N N 58  
A1LV6 C26 H17  sing N N 59  
A1LV6 C12 H18  sing N N 60  
A1LV6 C12 H19  sing N N 61  
A1LV6 C12 H20  sing N N 62  
A1LV6 C14 H21  sing N N 63  
A1LV6 C16 H22  sing N N 64  
A1LV6 C16 H23  sing N N 65  
A1LV6 C2  H24  sing N N 66  
A1LV6 C23 H25  sing N N 67  
A1LV6 C25 H26  sing N N 68  
A1LV6 C25 H27  sing N N 69  
A1LV6 C3  H28  sing N N 70  
A1LV6 C9  H29  sing N N 71  
A1LV6 O2  H31  sing N N 72  
ALA   N   CA   sing N N 73  
ALA   N   H    sing N N 74  
ALA   N   H2   sing N N 75  
ALA   CA  C    sing N N 76  
ALA   CA  CB   sing N N 77  
ALA   CA  HA   sing N N 78  
ALA   C   O    doub N N 79  
ALA   C   OXT  sing N N 80  
ALA   CB  HB1  sing N N 81  
ALA   CB  HB2  sing N N 82  
ALA   CB  HB3  sing N N 83  
ALA   OXT HXT  sing N N 84  
ARG   N   CA   sing N N 85  
ARG   N   H    sing N N 86  
ARG   N   H2   sing N N 87  
ARG   CA  C    sing N N 88  
ARG   CA  CB   sing N N 89  
ARG   CA  HA   sing N N 90  
ARG   C   O    doub N N 91  
ARG   C   OXT  sing N N 92  
ARG   CB  CG   sing N N 93  
ARG   CB  HB2  sing N N 94  
ARG   CB  HB3  sing N N 95  
ARG   CG  CD   sing N N 96  
ARG   CG  HG2  sing N N 97  
ARG   CG  HG3  sing N N 98  
ARG   CD  NE   sing N N 99  
ARG   CD  HD2  sing N N 100 
ARG   CD  HD3  sing N N 101 
ARG   NE  CZ   sing N N 102 
ARG   NE  HE   sing N N 103 
ARG   CZ  NH1  sing N N 104 
ARG   CZ  NH2  doub N N 105 
ARG   NH1 HH11 sing N N 106 
ARG   NH1 HH12 sing N N 107 
ARG   NH2 HH21 sing N N 108 
ARG   NH2 HH22 sing N N 109 
ARG   OXT HXT  sing N N 110 
ASN   N   CA   sing N N 111 
ASN   N   H    sing N N 112 
ASN   N   H2   sing N N 113 
ASN   CA  C    sing N N 114 
ASN   CA  CB   sing N N 115 
ASN   CA  HA   sing N N 116 
ASN   C   O    doub N N 117 
ASN   C   OXT  sing N N 118 
ASN   CB  CG   sing N N 119 
ASN   CB  HB2  sing N N 120 
ASN   CB  HB3  sing N N 121 
ASN   CG  OD1  doub N N 122 
ASN   CG  ND2  sing N N 123 
ASN   ND2 HD21 sing N N 124 
ASN   ND2 HD22 sing N N 125 
ASN   OXT HXT  sing N N 126 
ASP   N   CA   sing N N 127 
ASP   N   H    sing N N 128 
ASP   N   H2   sing N N 129 
ASP   CA  C    sing N N 130 
ASP   CA  CB   sing N N 131 
ASP   CA  HA   sing N N 132 
ASP   C   O    doub N N 133 
ASP   C   OXT  sing N N 134 
ASP   CB  CG   sing N N 135 
ASP   CB  HB2  sing N N 136 
ASP   CB  HB3  sing N N 137 
ASP   CG  OD1  doub N N 138 
ASP   CG  OD2  sing N N 139 
ASP   OD2 HD2  sing N N 140 
ASP   OXT HXT  sing N N 141 
CYS   N   CA   sing N N 142 
CYS   N   H    sing N N 143 
CYS   N   H2   sing N N 144 
CYS   CA  C    sing N N 145 
CYS   CA  CB   sing N N 146 
CYS   CA  HA   sing N N 147 
CYS   C   O    doub N N 148 
CYS   C   OXT  sing N N 149 
CYS   CB  SG   sing N N 150 
CYS   CB  HB2  sing N N 151 
CYS   CB  HB3  sing N N 152 
CYS   SG  HG   sing N N 153 
CYS   OXT HXT  sing N N 154 
GLN   N   CA   sing N N 155 
GLN   N   H    sing N N 156 
GLN   N   H2   sing N N 157 
GLN   CA  C    sing N N 158 
GLN   CA  CB   sing N N 159 
GLN   CA  HA   sing N N 160 
GLN   C   O    doub N N 161 
GLN   C   OXT  sing N N 162 
GLN   CB  CG   sing N N 163 
GLN   CB  HB2  sing N N 164 
GLN   CB  HB3  sing N N 165 
GLN   CG  CD   sing N N 166 
GLN   CG  HG2  sing N N 167 
GLN   CG  HG3  sing N N 168 
GLN   CD  OE1  doub N N 169 
GLN   CD  NE2  sing N N 170 
GLN   NE2 HE21 sing N N 171 
GLN   NE2 HE22 sing N N 172 
GLN   OXT HXT  sing N N 173 
GLU   N   CA   sing N N 174 
GLU   N   H    sing N N 175 
GLU   N   H2   sing N N 176 
GLU   CA  C    sing N N 177 
GLU   CA  CB   sing N N 178 
GLU   CA  HA   sing N N 179 
GLU   C   O    doub N N 180 
GLU   C   OXT  sing N N 181 
GLU   CB  CG   sing N N 182 
GLU   CB  HB2  sing N N 183 
GLU   CB  HB3  sing N N 184 
GLU   CG  CD   sing N N 185 
GLU   CG  HG2  sing N N 186 
GLU   CG  HG3  sing N N 187 
GLU   CD  OE1  doub N N 188 
GLU   CD  OE2  sing N N 189 
GLU   OE2 HE2  sing N N 190 
GLU   OXT HXT  sing N N 191 
GLY   N   CA   sing N N 192 
GLY   N   H    sing N N 193 
GLY   N   H2   sing N N 194 
GLY   CA  C    sing N N 195 
GLY   CA  HA2  sing N N 196 
GLY   CA  HA3  sing N N 197 
GLY   C   O    doub N N 198 
GLY   C   OXT  sing N N 199 
GLY   OXT HXT  sing N N 200 
HIS   N   CA   sing N N 201 
HIS   N   H    sing N N 202 
HIS   N   H2   sing N N 203 
HIS   CA  C    sing N N 204 
HIS   CA  CB   sing N N 205 
HIS   CA  HA   sing N N 206 
HIS   C   O    doub N N 207 
HIS   C   OXT  sing N N 208 
HIS   CB  CG   sing N N 209 
HIS   CB  HB2  sing N N 210 
HIS   CB  HB3  sing N N 211 
HIS   CG  ND1  sing Y N 212 
HIS   CG  CD2  doub Y N 213 
HIS   ND1 CE1  doub Y N 214 
HIS   ND1 HD1  sing N N 215 
HIS   CD2 NE2  sing Y N 216 
HIS   CD2 HD2  sing N N 217 
HIS   CE1 NE2  sing Y N 218 
HIS   CE1 HE1  sing N N 219 
HIS   NE2 HE2  sing N N 220 
HIS   OXT HXT  sing N N 221 
HOH   O   H1   sing N N 222 
HOH   O   H2   sing N N 223 
ILE   N   CA   sing N N 224 
ILE   N   H    sing N N 225 
ILE   N   H2   sing N N 226 
ILE   CA  C    sing N N 227 
ILE   CA  CB   sing N N 228 
ILE   CA  HA   sing N N 229 
ILE   C   O    doub N N 230 
ILE   C   OXT  sing N N 231 
ILE   CB  CG1  sing N N 232 
ILE   CB  CG2  sing N N 233 
ILE   CB  HB   sing N N 234 
ILE   CG1 CD1  sing N N 235 
ILE   CG1 HG12 sing N N 236 
ILE   CG1 HG13 sing N N 237 
ILE   CG2 HG21 sing N N 238 
ILE   CG2 HG22 sing N N 239 
ILE   CG2 HG23 sing N N 240 
ILE   CD1 HD11 sing N N 241 
ILE   CD1 HD12 sing N N 242 
ILE   CD1 HD13 sing N N 243 
ILE   OXT HXT  sing N N 244 
LEU   N   CA   sing N N 245 
LEU   N   H    sing N N 246 
LEU   N   H2   sing N N 247 
LEU   CA  C    sing N N 248 
LEU   CA  CB   sing N N 249 
LEU   CA  HA   sing N N 250 
LEU   C   O    doub N N 251 
LEU   C   OXT  sing N N 252 
LEU   CB  CG   sing N N 253 
LEU   CB  HB2  sing N N 254 
LEU   CB  HB3  sing N N 255 
LEU   CG  CD1  sing N N 256 
LEU   CG  CD2  sing N N 257 
LEU   CG  HG   sing N N 258 
LEU   CD1 HD11 sing N N 259 
LEU   CD1 HD12 sing N N 260 
LEU   CD1 HD13 sing N N 261 
LEU   CD2 HD21 sing N N 262 
LEU   CD2 HD22 sing N N 263 
LEU   CD2 HD23 sing N N 264 
LEU   OXT HXT  sing N N 265 
LYS   N   CA   sing N N 266 
LYS   N   H    sing N N 267 
LYS   N   H2   sing N N 268 
LYS   CA  C    sing N N 269 
LYS   CA  CB   sing N N 270 
LYS   CA  HA   sing N N 271 
LYS   C   O    doub N N 272 
LYS   C   OXT  sing N N 273 
LYS   CB  CG   sing N N 274 
LYS   CB  HB2  sing N N 275 
LYS   CB  HB3  sing N N 276 
LYS   CG  CD   sing N N 277 
LYS   CG  HG2  sing N N 278 
LYS   CG  HG3  sing N N 279 
LYS   CD  CE   sing N N 280 
LYS   CD  HD2  sing N N 281 
LYS   CD  HD3  sing N N 282 
LYS   CE  NZ   sing N N 283 
LYS   CE  HE2  sing N N 284 
LYS   CE  HE3  sing N N 285 
LYS   NZ  HZ1  sing N N 286 
LYS   NZ  HZ2  sing N N 287 
LYS   NZ  HZ3  sing N N 288 
LYS   OXT HXT  sing N N 289 
MET   N   CA   sing N N 290 
MET   N   H    sing N N 291 
MET   N   H2   sing N N 292 
MET   CA  C    sing N N 293 
MET   CA  CB   sing N N 294 
MET   CA  HA   sing N N 295 
MET   C   O    doub N N 296 
MET   C   OXT  sing N N 297 
MET   CB  CG   sing N N 298 
MET   CB  HB2  sing N N 299 
MET   CB  HB3  sing N N 300 
MET   CG  SD   sing N N 301 
MET   CG  HG2  sing N N 302 
MET   CG  HG3  sing N N 303 
MET   SD  CE   sing N N 304 
MET   CE  HE1  sing N N 305 
MET   CE  HE2  sing N N 306 
MET   CE  HE3  sing N N 307 
MET   OXT HXT  sing N N 308 
PHE   N   CA   sing N N 309 
PHE   N   H    sing N N 310 
PHE   N   H2   sing N N 311 
PHE   CA  C    sing N N 312 
PHE   CA  CB   sing N N 313 
PHE   CA  HA   sing N N 314 
PHE   C   O    doub N N 315 
PHE   C   OXT  sing N N 316 
PHE   CB  CG   sing N N 317 
PHE   CB  HB2  sing N N 318 
PHE   CB  HB3  sing N N 319 
PHE   CG  CD1  doub Y N 320 
PHE   CG  CD2  sing Y N 321 
PHE   CD1 CE1  sing Y N 322 
PHE   CD1 HD1  sing N N 323 
PHE   CD2 CE2  doub Y N 324 
PHE   CD2 HD2  sing N N 325 
PHE   CE1 CZ   doub Y N 326 
PHE   CE1 HE1  sing N N 327 
PHE   CE2 CZ   sing Y N 328 
PHE   CE2 HE2  sing N N 329 
PHE   CZ  HZ   sing N N 330 
PHE   OXT HXT  sing N N 331 
PRO   N   CA   sing N N 332 
PRO   N   CD   sing N N 333 
PRO   N   H    sing N N 334 
PRO   CA  C    sing N N 335 
PRO   CA  CB   sing N N 336 
PRO   CA  HA   sing N N 337 
PRO   C   O    doub N N 338 
PRO   C   OXT  sing N N 339 
PRO   CB  CG   sing N N 340 
PRO   CB  HB2  sing N N 341 
PRO   CB  HB3  sing N N 342 
PRO   CG  CD   sing N N 343 
PRO   CG  HG2  sing N N 344 
PRO   CG  HG3  sing N N 345 
PRO   CD  HD2  sing N N 346 
PRO   CD  HD3  sing N N 347 
PRO   OXT HXT  sing N N 348 
SER   N   CA   sing N N 349 
SER   N   H    sing N N 350 
SER   N   H2   sing N N 351 
SER   CA  C    sing N N 352 
SER   CA  CB   sing N N 353 
SER   CA  HA   sing N N 354 
SER   C   O    doub N N 355 
SER   C   OXT  sing N N 356 
SER   CB  OG   sing N N 357 
SER   CB  HB2  sing N N 358 
SER   CB  HB3  sing N N 359 
SER   OG  HG   sing N N 360 
SER   OXT HXT  sing N N 361 
THR   N   CA   sing N N 362 
THR   N   H    sing N N 363 
THR   N   H2   sing N N 364 
THR   CA  C    sing N N 365 
THR   CA  CB   sing N N 366 
THR   CA  HA   sing N N 367 
THR   C   O    doub N N 368 
THR   C   OXT  sing N N 369 
THR   CB  OG1  sing N N 370 
THR   CB  CG2  sing N N 371 
THR   CB  HB   sing N N 372 
THR   OG1 HG1  sing N N 373 
THR   CG2 HG21 sing N N 374 
THR   CG2 HG22 sing N N 375 
THR   CG2 HG23 sing N N 376 
THR   OXT HXT  sing N N 377 
TRP   N   CA   sing N N 378 
TRP   N   H    sing N N 379 
TRP   N   H2   sing N N 380 
TRP   CA  C    sing N N 381 
TRP   CA  CB   sing N N 382 
TRP   CA  HA   sing N N 383 
TRP   C   O    doub N N 384 
TRP   C   OXT  sing N N 385 
TRP   CB  CG   sing N N 386 
TRP   CB  HB2  sing N N 387 
TRP   CB  HB3  sing N N 388 
TRP   CG  CD1  doub Y N 389 
TRP   CG  CD2  sing Y N 390 
TRP   CD1 NE1  sing Y N 391 
TRP   CD1 HD1  sing N N 392 
TRP   CD2 CE2  doub Y N 393 
TRP   CD2 CE3  sing Y N 394 
TRP   NE1 CE2  sing Y N 395 
TRP   NE1 HE1  sing N N 396 
TRP   CE2 CZ2  sing Y N 397 
TRP   CE3 CZ3  doub Y N 398 
TRP   CE3 HE3  sing N N 399 
TRP   CZ2 CH2  doub Y N 400 
TRP   CZ2 HZ2  sing N N 401 
TRP   CZ3 CH2  sing Y N 402 
TRP   CZ3 HZ3  sing N N 403 
TRP   CH2 HH2  sing N N 404 
TRP   OXT HXT  sing N N 405 
TYR   N   CA   sing N N 406 
TYR   N   H    sing N N 407 
TYR   N   H2   sing N N 408 
TYR   CA  C    sing N N 409 
TYR   CA  CB   sing N N 410 
TYR   CA  HA   sing N N 411 
TYR   C   O    doub N N 412 
TYR   C   OXT  sing N N 413 
TYR   CB  CG   sing N N 414 
TYR   CB  HB2  sing N N 415 
TYR   CB  HB3  sing N N 416 
TYR   CG  CD1  doub Y N 417 
TYR   CG  CD2  sing Y N 418 
TYR   CD1 CE1  sing Y N 419 
TYR   CD1 HD1  sing N N 420 
TYR   CD2 CE2  doub Y N 421 
TYR   CD2 HD2  sing N N 422 
TYR   CE1 CZ   doub Y N 423 
TYR   CE1 HE1  sing N N 424 
TYR   CE2 CZ   sing Y N 425 
TYR   CE2 HE2  sing N N 426 
TYR   CZ  OH   sing N N 427 
TYR   OH  HH   sing N N 428 
TYR   OXT HXT  sing N N 429 
VAL   N   CA   sing N N 430 
VAL   N   H    sing N N 431 
VAL   N   H2   sing N N 432 
VAL   CA  C    sing N N 433 
VAL   CA  CB   sing N N 434 
VAL   CA  HA   sing N N 435 
VAL   C   O    doub N N 436 
VAL   C   OXT  sing N N 437 
VAL   CB  CG1  sing N N 438 
VAL   CB  CG2  sing N N 439 
VAL   CB  HB   sing N N 440 
VAL   CG1 HG11 sing N N 441 
VAL   CG1 HG12 sing N N 442 
VAL   CG1 HG13 sing N N 443 
VAL   CG2 HG21 sing N N 444 
VAL   CG2 HG22 sing N N 445 
VAL   CG2 HG23 sing N N 446 
VAL   OXT HXT  sing N N 447 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4XG3 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8XQ1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.025232 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000007 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011744 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011172 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . TYR   A 1 9   ? -2.06467  12.98323  30.60307  1.000 40.26529 ? 364  TYR   A N   1 
ATOM   2    C CA  . TYR   A 1 9   ? -1.30674  13.69958  29.56540  1.000 33.00239 ? 364  TYR   A CA  1 
ATOM   3    C C   . TYR   A 1 9   ? -1.05741  15.16151  29.92126  1.000 30.41433 ? 364  TYR   A C   1 
ATOM   4    O O   . TYR   A 1 9   ? -1.98781  15.89391  30.26652  1.000 36.35999 ? 364  TYR   A O   1 
ATOM   5    C CB  . TYR   A 1 9   ? -2.02948  13.58124  28.22364  1.000 39.60225 ? 364  TYR   A CB  1 
ATOM   6    C CG  . TYR   A 1 9   ? -1.78171  12.22986  27.57958  1.000 37.60376 ? 364  TYR   A CG  1 
ATOM   7    C CD1 . TYR   A 1 9   ? -2.43456  11.09053  28.04393  1.000 46.75022 ? 364  TYR   A CD1 1 
ATOM   8    C CD2 . TYR   A 1 9   ? -0.88243  12.08957  26.53652  1.000 31.25677 ? 364  TYR   A CD2 1 
ATOM   9    C CE1 . TYR   A 1 9   ? -2.20795  9.83558   27.47047  1.000 47.43796 ? 364  TYR   A CE1 1 
ATOM   10   C CE2 . TYR   A 1 9   ? -0.64670  10.83662  25.95366  1.000 46.11330 ? 364  TYR   A CE2 1 
ATOM   11   C CZ  . TYR   A 1 9   ? -1.31256  9.71578   26.43376  1.000 45.06427 ? 364  TYR   A CZ  1 
ATOM   12   O OH  . TYR   A 1 9   ? -1.08580  8.47012   25.87771  1.000 47.99704 ? 364  TYR   A OH  1 
ATOM   13   N N   . LEU   A 1 10  ? 0.19957   15.58033  29.82376  1.000 24.90828 ? 365  LEU   A N   1 
ATOM   14   C CA  . LEU   A 1 10  ? 0.60596   16.93287  30.16999  1.000 24.74310 ? 365  LEU   A CA  1 
ATOM   15   C C   . LEU   A 1 10  ? 0.53576   17.86859  28.96523  1.000 27.11337 ? 365  LEU   A C   1 
ATOM   16   O O   . LEU   A 1 10  ? 0.57547   17.45103  27.80032  1.000 26.29148 ? 365  LEU   A O   1 
ATOM   17   C CB  . LEU   A 1 10  ? 2.03152   16.94082  30.71977  1.000 20.60777 ? 365  LEU   A CB  1 
ATOM   18   C CG  . LEU   A 1 10  ? 2.21956   15.92834  31.85440  1.000 21.44342 ? 365  LEU   A CG  1 
ATOM   19   C CD1 . LEU   A 1 10  ? 3.69559   15.92017  32.23004  1.000 23.07547 ? 365  LEU   A CD1 1 
ATOM   20   C CD2 . LEU   A 1 10  ? 1.33380   16.34666  33.02338  1.000 25.47768 ? 365  LEU   A CD2 1 
ATOM   21   N N   . ASP   A 1 11  ? 0.54856   19.16201  29.27589  1.000 25.41568 ? 366  ASP   A N   1 
ATOM   22   C CA  . ASP   A 1 11  ? 0.46081   20.24619  28.29940  1.000 25.91330 ? 366  ASP   A CA  1 
ATOM   23   C C   . ASP   A 1 11  ? 1.87211   20.65767  27.88079  1.000 28.60888 ? 366  ASP   A C   1 
ATOM   24   O O   . ASP   A 1 11  ? 2.64506   21.17497  28.70063  1.000 26.99692 ? 366  ASP   A O   1 
ATOM   25   C CB  . ASP   A 1 11  ? -0.31374  21.39474  28.95542  1.000 28.04730 ? 366  ASP   A CB  1 
ATOM   26   C CG  . ASP   A 1 11  ? -0.56346  22.57278  28.01678  1.000 40.02662 ? 366  ASP   A CG  1 
ATOM   27   O OD1 . ASP   A 1 11  ? -0.03273  22.58484  26.88219  1.000 36.31701 ? 366  ASP   A OD1 1 
ATOM   28   O OD2 . ASP   A 1 11  ? -1.28886  23.49390  28.44584  1.000 40.93318 ? 366  ASP   A OD2 1 
ATOM   29   N N   . ARG   A 1 12  ? 2.23239   20.41970  26.60928  1.000 25.00581 ? 367  ARG   A N   1 
ATOM   30   C CA  . ARG   A 1 12  ? 3.59989   20.69523  26.18063  1.000 21.96528 ? 367  ARG   A CA  1 
ATOM   31   C C   . ARG   A 1 12  ? 3.97893   22.15087  26.39997  1.000 25.64285 ? 367  ARG   A C   1 
ATOM   32   O O   . ARG   A 1 12  ? 5.16859   22.46467  26.54060  1.000 26.39448 ? 367  ARG   A O   1 
ATOM   33   C CB  . ARG   A 1 12  ? 3.80240   20.30587  24.69660  1.000 24.97632 ? 367  ARG   A CB  1 
ATOM   34   C CG  . ARG   A 1 12  ? 5.24891   20.52097  24.12104  1.000 25.45012 ? 367  ARG   A CG  1 
ATOM   35   C CD  . ARG   A 1 12  ? 6.34920   19.67550  24.78017  1.000 26.72744 ? 367  ARG   A CD  1 
ATOM   36   N NE  . ARG   A 1 12  ? 7.69492   19.91796  24.24978  1.000 25.77164 ? 367  ARG   A NE  1 
ATOM   37   C CZ  . ARG   A 1 12  ? 8.51889   20.85429  24.70946  1.000 30.52359 ? 367  ARG   A CZ  1 
ATOM   38   N NH1 . ARG   A 1 12  ? 8.15168   21.69160  25.67601  1.000 27.84069 ? 367  ARG   A NH1 1 
ATOM   39   N NH2 . ARG   A 1 12  ? 9.74020   20.95464  24.19534  1.000 33.21119 ? 367  ARG   A NH2 1 
ATOM   40   N N   . LYS   A 1 13  ? 3.00246   23.05528  26.38109  1.000 26.85543 ? 368  LYS   A N   1 
ATOM   41   C CA  . LYS   A 1 13  ? 3.35347   24.45793  26.53081  1.000 26.39722 ? 368  LYS   A CA  1 
ATOM   42   C C   . LYS   A 1 13  ? 3.64070   24.82889  27.98273  1.000 31.06873 ? 368  LYS   A C   1 
ATOM   43   O O   . LYS   A 1 13  ? 4.21879   25.89469  28.23074  1.000 29.50795 ? 368  LYS   A O   1 
ATOM   44   C CB  . LYS   A 1 13  ? 2.25418   25.34178  25.92999  1.000 38.00101 ? 368  LYS   A CB  1 
ATOM   45   C CG  . LYS   A 1 13  ? 0.97545   25.36946  26.71386  1.000 39.16480 ? 368  LYS   A CG  1 
ATOM   46   C CD  . LYS   A 1 13  ? -0.19749  25.89176  25.86748  1.000 47.79180 ? 368  LYS   A CD  1 
ATOM   47   C CE  . LYS   A 1 13  ? -1.45826  26.03116  26.72826  1.000 50.94248 ? 368  LYS   A CE  1 
ATOM   48   N NZ  . LYS   A 1 13  ? -1.12942  26.12894  28.20704  1.000 38.61253 ? 368  LYS   A NZ  1 
ATOM   49   N N   . LEU   A 1 14  ? 3.33339   23.94598  28.93743  1.000 25.68436 ? 369  LEU   A N   1 
ATOM   50   C CA  . LEU   A 1 14  ? 3.72618   24.15829  30.33216  1.000 24.75504 ? 369  LEU   A CA  1 
ATOM   51   C C   . LEU   A 1 14  ? 5.06482   23.50202  30.65346  1.000 23.76180 ? 369  LEU   A C   1 
ATOM   52   O O   . LEU   A 1 14  ? 5.61437   23.71286  31.74639  1.000 21.89980 ? 369  LEU   A O   1 
ATOM   53   C CB  . LEU   A 1 14  ? 2.64993   23.63009  31.25870  1.000 23.98028 ? 369  LEU   A CB  1 
ATOM   54   C CG  . LEU   A 1 14  ? 1.27711   24.31658  31.12149  1.000 25.21469 ? 369  LEU   A CG  1 
ATOM   55   C CD1 . LEU   A 1 14  ? 0.33668   23.62037  32.06137  1.000 27.63411 ? 369  LEU   A CD1 1 
ATOM   56   C CD2 . LEU   A 1 14  ? 1.38727   25.77083  31.48849  1.000 30.11291 ? 369  LEU   A CD2 1 
ATOM   57   N N   . LEU   A 1 15  ? 5.63040   22.79621  29.69784  1.000 21.87499 ? 370  LEU   A N   1 
ATOM   58   C CA  . LEU   A 1 15  ? 6.91633   22.12120  29.83137  1.000 20.40486 ? 370  LEU   A CA  1 
ATOM   59   C C   . LEU   A 1 15  ? 8.01516   22.91843  29.13469  1.000 23.03741 ? 370  LEU   A C   1 
ATOM   60   O O   . LEU   A 1 15  ? 7.90450   23.24724  27.94711  1.000 25.16160 ? 370  LEU   A O   1 
ATOM   61   C CB  . LEU   A 1 15  ? 6.83704   20.69796  29.25058  1.000 19.74423 ? 370  LEU   A CB  1 
ATOM   62   C CG  . LEU   A 1 15  ? 8.10297   19.84545  29.40387  1.000 27.61661 ? 370  LEU   A CG  1 
ATOM   63   C CD1 . LEU   A 1 15  ? 8.45940   19.61618  30.91474  1.000 24.40773 ? 370  LEU   A CD1 1 
ATOM   64   C CD2 . LEU   A 1 15  ? 7.87071   18.51403  28.67075  1.000 23.83267 ? 370  LEU   A CD2 1 
ATOM   65   N N   . THR   A 1 16  ? 9.10141   23.20242  29.85379  1.000 23.37655 ? 371  THR   A N   1 
ATOM   66   C CA  . THR   A 1 16  ? 10.29343  23.80993  29.28305  1.000 24.09519 ? 371  THR   A CA  1 
ATOM   67   C C   . THR   A 1 16  ? 11.44663  22.83030  29.43178  1.000 24.36422 ? 371  THR   A C   1 
ATOM   68   O O   . THR   A 1 16  ? 11.79948  22.47939  30.55978  1.000 28.24162 ? 371  THR   A O   1 
ATOM   69   C CB  . THR   A 1 16  ? 10.62981  25.13147  29.98956  1.000 26.53608 ? 371  THR   A CB  1 
ATOM   70   O OG1 . THR   A 1 16  ? 9.46595   25.98155  30.02177  1.000 30.19709 ? 371  THR   A OG1 1 
ATOM   71   C CG2 . THR   A 1 16  ? 11.73260  25.82612  29.27025  1.000 27.72553 ? 371  THR   A CG2 1 
ATOM   72   N N   . LEU   A 1 17  ? 12.04800  22.40501  28.32228  1.000 25.34385 ? 372  LEU   A N   1 
ATOM   73   C CA  . LEU   A 1 17  ? 13.22276  21.52722  28.35517  1.000 22.89448 ? 372  LEU   A CA  1 
ATOM   74   C C   . LEU   A 1 17  ? 14.52968  22.29709  28.23859  1.000 26.29201 ? 372  LEU   A C   1 
ATOM   75   O O   . LEU   A 1 17  ? 14.63534  23.25987  27.46347  1.000 29.15475 ? 372  LEU   A O   1 
ATOM   76   C CB  . LEU   A 1 17  ? 13.19319  20.49780  27.22741  1.000 24.26451 ? 372  LEU   A CB  1 
ATOM   77   C CG  . LEU   A 1 17  ? 12.02839  19.53203  27.29517  1.000 24.46015 ? 372  LEU   A CG  1 
ATOM   78   C CD1 . LEU   A 1 17  ? 12.00190  18.64361  26.06992  1.000 33.88608 ? 372  LEU   A CD1 1 
ATOM   79   C CD2 . LEU   A 1 17  ? 12.19272  18.67988  28.56494  1.000 26.59570 ? 372  LEU   A CD2 1 
ATOM   80   N N   . GLU   A 1 18  ? 15.54183  21.86320  28.98867  1.000 22.32981 ? 373  GLU   A N   1 
ATOM   81   C CA  . GLU   A 1 18  ? 16.88359  22.36989  28.78846  1.000 22.81180 ? 373  GLU   A CA  1 
ATOM   82   C C   . GLU   A 1 18  ? 17.51681  21.69233  27.57608  1.000 31.34128 ? 373  GLU   A C   1 
ATOM   83   O O   . GLU   A 1 18  ? 17.19314  20.55213  27.24179  1.000 38.27215 ? 373  GLU   A O   1 
ATOM   84   C CB  . GLU   A 1 18  ? 17.75003  22.11974  30.00930  1.000 27.87690 ? 373  GLU   A CB  1 
ATOM   85   C CG  . GLU   A 1 18  ? 17.31592  22.86301  31.26457  1.000 33.51009 ? 373  GLU   A CG  1 
ATOM   86   C CD  . GLU   A 1 18  ? 18.46542  23.00868  32.26580  1.000 56.12914 ? 373  GLU   A CD  1 
ATOM   87   O OE1 . GLU   A 1 18  ? 19.37493  22.13777  32.24595  1.000 58.77269 ? 373  GLU   A OE1 1 
ATOM   88   O OE2 . GLU   A 1 18  ? 18.46793  23.98844  33.06139  1.000 53.74182 ? 373  GLU   A OE2 1 
ATOM   89   N N   . ASP   A 1 19  ? 18.43260  22.40147  26.91759  1.000 40.14540 ? 374  ASP   A N   1 
ATOM   90   C CA  . ASP   A 1 19  ? 18.98910  21.87239  25.67175  1.000 36.27264 ? 374  ASP   A CA  1 
ATOM   91   C C   . ASP   A 1 19  ? 19.95132  20.72460  25.92847  1.000 35.67500 ? 374  ASP   A C   1 
ATOM   92   O O   . ASP   A 1 19  ? 19.93127  19.71440  25.21151  1.000 39.04487 ? 374  ASP   A O   1 
ATOM   93   C CB  . ASP   A 1 19  ? 19.68333  22.97830  24.87617  1.000 43.40074 ? 374  ASP   A CB  1 
ATOM   94   C CG  . ASP   A 1 19  ? 18.71719  23.76063  23.98626  1.000 56.76514 ? 374  ASP   A CG  1 
ATOM   95   O OD1 . ASP   A 1 19  ? 17.70320  23.17724  23.53406  1.000 48.95353 ? 374  ASP   A OD1 1 
ATOM   96   O OD2 . ASP   A 1 19  ? 18.97752  24.96180  23.73518  1.000 61.55422 ? 374  ASP   A OD2 1 
ATOM   97   N N   . LYS   A 1 20  ? 20.78187  20.84122  26.95054  1.000 29.67473 ? 375  LYS   A N   1 
ATOM   98   C CA  . LYS   A 1 20  ? 21.84077  19.86590  27.15771  1.000 33.49229 ? 375  LYS   A CA  1 
ATOM   99   C C   . LYS   A 1 20  ? 21.28414  18.66001  27.90457  1.000 32.20348 ? 375  LYS   A C   1 
ATOM   100  O O   . LYS   A 1 20  ? 20.60415  18.81008  28.91936  1.000 36.76513 ? 375  LYS   A O   1 
ATOM   101  C CB  . LYS   A 1 20  ? 23.00567  20.48266  27.92397  1.000 39.56003 ? 375  LYS   A CB  1 
ATOM   102  C CG  . LYS   A 1 20  ? 24.04289  19.46271  28.37751  1.000 47.34780 ? 375  LYS   A CG  1 
ATOM   103  C CD  . LYS   A 1 20  ? 24.68416  18.75675  27.17938  1.000 63.13374 ? 375  LYS   A CD  1 
ATOM   104  C CE  . LYS   A 1 20  ? 25.12778  17.33374  27.50993  1.000 63.02911 ? 375  LYS   A CE  1 
ATOM   105  N NZ  . LYS   A 1 20  ? 26.00685  17.23459  28.71177  1.000 65.85705 ? 375  LYS   A NZ  1 
ATOM   106  N N   . GLU   A 1 21  ? 21.57535  17.47013  27.40268  1.000 30.19480 ? 376  GLU   A N   1 
ATOM   107  C CA  . GLU   A 1 21  ? 21.09865  16.25596  28.05894  1.000 29.72173 ? 376  GLU   A CA  1 
ATOM   108  C C   . GLU   A 1 21  ? 21.82569  16.00366  29.37337  1.000 28.58343 ? 376  GLU   A C   1 
ATOM   109  O O   . GLU   A 1 21  ? 23.01768  16.28878  29.51376  1.000 27.52178 ? 376  GLU   A O   1 
ATOM   110  C CB  . GLU   A 1 21  ? 21.29616  15.05067  27.13820  1.000 33.26498 ? 376  GLU   A CB  1 
ATOM   111  C CG  . GLU   A 1 21  ? 21.36002  15.40664  25.67271  1.000 47.54401 ? 376  GLU   A CG  1 
ATOM   112  C CD  . GLU   A 1 21  ? 21.74315  14.22219  24.80004  1.000 55.24696 ? 376  GLU   A CD  1 
ATOM   113  O OE1 . GLU   A 1 21  ? 22.28883  13.22237  25.33252  1.000 49.66953 ? 376  GLU   A OE1 1 
ATOM   114  O OE2 . GLU   A 1 21  ? 21.49576  14.29914  23.57720  1.000 63.32627 ? 376  GLU   A OE2 1 
ATOM   115  N N   . LEU   A 1 22  ? 21.09920  15.43202  30.34659  1.000 23.34549 ? 377  LEU   A N   1 
ATOM   116  C CA  . LEU   A 1 22  ? 21.74724  14.90752  31.55327  1.000 25.90061 ? 377  LEU   A CA  1 
ATOM   117  C C   . LEU   A 1 22  ? 22.44982  13.59164  31.27810  1.000 27.20811 ? 377  LEU   A C   1 
ATOM   118  O O   . LEU   A 1 22  ? 23.47598  13.28019  31.91125  1.000 24.65476 ? 377  LEU   A O   1 
ATOM   119  C CB  . LEU   A 1 22  ? 20.71425  14.70556  32.67874  1.000 20.61939 ? 377  LEU   A CB  1 
ATOM   120  C CG  . LEU   A 1 22  ? 20.14221  15.99615  33.19465  1.000 22.63719 ? 377  LEU   A CG  1 
ATOM   121  C CD1 . LEU   A 1 22  ? 19.16123  15.69961  34.33563  1.000 21.51217 ? 377  LEU   A CD1 1 
ATOM   122  C CD2 . LEU   A 1 22  ? 21.31682  16.79585  33.68672  1.000 29.12645 ? 377  LEU   A CD2 1 
ATOM   123  N N   . GLY   A 1 23  ? 21.86910  12.79078  30.38723  1.000 21.81381 ? 378  GLY   A N   1 
ATOM   124  C CA  . GLY   A 1 23  ? 22.35190  11.45925  30.06962  1.000 26.24370 ? 378  GLY   A CA  1 
ATOM   125  C C   . GLY   A 1 23  ? 21.64290  10.88485  28.86351  1.000 22.57497 ? 378  GLY   A C   1 
ATOM   126  O O   . GLY   A 1 23  ? 20.65967  11.43894  28.34522  1.000 23.16992 ? 378  GLY   A O   1 
ATOM   127  N N   . SER   A 1 24  ? 22.15695  9.73122   28.43617  1.000 23.20851 ? 379  SER   A N   1 
ATOM   128  C CA  . SER   A 1 24  ? 21.69573  9.08640   27.22358  1.000 25.54022 ? 379  SER   A CA  1 
ATOM   129  C C   . SER   A 1 24  ? 21.82669  7.59252   27.43936  1.000 38.26143 ? 379  SER   A C   1 
ATOM   130  O O   . SER   A 1 24  ? 22.60603  7.13168   28.27944  1.000 33.15492 ? 379  SER   A O   1 
ATOM   131  C CB  . SER   A 1 24  ? 22.53097  9.49961   26.00127  1.000 39.41231 ? 379  SER   A CB  1 
ATOM   132  O OG  . SER   A 1 24  ? 21.96842  10.62116  25.36066  1.000 52.60024 ? 379  SER   A OG  1 
ATOM   133  N N   . GLY   A 1 25  ? 21.04944  6.85050   26.67338  1.000 32.22638 ? 380  GLY   A N   1 
ATOM   134  C CA  . GLY   A 1 25  ? 21.19817  5.41832   26.59617  1.000 40.90974 ? 380  GLY   A CA  1 
ATOM   135  C C   . GLY   A 1 25  ? 20.42342  4.91375   25.40557  1.000 35.93572 ? 380  GLY   A C   1 
ATOM   136  O O   . GLY   A 1 25  ? 19.88652  5.69499   24.61830  1.000 36.70503 ? 380  GLY   A O   1 
ATOM   137  N N   . ASN   A 1 26  ? 20.36925  3.58529   25.26911  1.000 46.87461 ? 381  ASN   A N   1 
ATOM   138  C CA  . ASN   A 1 26  ? 19.49318  3.02162   24.25033  1.000 38.07895 ? 381  ASN   A CA  1 
ATOM   139  C C   . ASN   A 1 26  ? 18.04525  3.37931   24.52630  1.000 45.00147 ? 381  ASN   A C   1 
ATOM   140  O O   . ASN   A 1 26  ? 17.20598  3.28087   23.62524  1.000 48.57650 ? 381  ASN   A O   1 
ATOM   141  C CB  . ASN   A 1 26  ? 19.64286  1.49833   24.18569  1.000 45.82989 ? 381  ASN   A CB  1 
ATOM   142  C CG  . ASN   A 1 26  ? 21.07854  1.06474   23.99517  1.000 57.85224 ? 381  ASN   A CG  1 
ATOM   143  O OD1 . ASN   A 1 26  ? 21.88286  1.79102   23.40725  1.000 65.25247 ? 381  ASN   A OD1 1 
ATOM   144  N ND2 . ASN   A 1 26  ? 21.41362  -0.12020  24.49898  1.000 56.49651 ? 381  ASN   A ND2 1 
ATOM   145  N N   . PHE   A 1 27  ? 17.73983  3.78979   25.76008  1.000 42.63874 ? 382  PHE   A N   1 
ATOM   146  C CA  . PHE   A 1 27  ? 16.38834  4.19524   26.12378  1.000 45.70091 ? 382  PHE   A CA  1 
ATOM   147  C C   . PHE   A 1 27  ? 15.97413  5.52175   25.49351  1.000 46.90509 ? 382  PHE   A C   1 
ATOM   148  O O   . PHE   A 1 27  ? 14.77772  5.83121   25.51828  1.000 50.88234 ? 382  PHE   A O   1 
ATOM   149  C CB  . PHE   A 1 27  ? 16.25784  4.26612   27.65694  1.000 35.10306 ? 382  PHE   A CB  1 
ATOM   150  C CG  . PHE   A 1 27  ? 17.06783  5.35617   28.29664  1.000 35.95412 ? 382  PHE   A CG  1 
ATOM   151  C CD1 . PHE   A 1 27  ? 16.55068  6.63468   28.43521  1.000 35.81297 ? 382  PHE   A CD1 1 
ATOM   152  C CD2 . PHE   A 1 27  ? 18.35347  5.10635   28.75547  1.000 33.82824 ? 382  PHE   A CD2 1 
ATOM   153  C CE1 . PHE   A 1 27  ? 17.28069  7.61597   29.01711  1.000 35.83122 ? 382  PHE   A CE1 1 
ATOM   154  C CE2 . PHE   A 1 27  ? 19.10306  6.10497   29.33837  1.000 36.66419 ? 382  PHE   A CE2 1 
ATOM   155  C CZ  . PHE   A 1 27  ? 18.56014  7.36275   29.48586  1.000 30.01107 ? 382  PHE   A CZ  1 
ATOM   156  N N   . GLY   A 1 28  ? 16.91730  6.28427   24.90451  1.000 36.70762 ? 383  GLY   A N   1 
ATOM   157  C CA  . GLY   A 1 28  ? 16.71350  7.66521   24.49053  1.000 33.32453 ? 383  GLY   A CA  1 
ATOM   158  C C   . GLY   A 1 28  ? 17.58399  8.61142   25.30446  1.000 30.93809 ? 383  GLY   A C   1 
ATOM   159  O O   . GLY   A 1 28  ? 18.74909  8.30397   25.56194  1.000 29.13527 ? 383  GLY   A O   1 
ATOM   160  N N   . THR   A 1 29  ? 17.03732  9.73558   25.76945  1.000 23.18526 ? 384  THR   A N   1 
ATOM   161  C CA  . THR   A 1 29  ? 17.82974  10.67272  26.55482  1.000 21.04396 ? 384  THR   A CA  1 
ATOM   162  C C   . THR   A 1 29  ? 17.05659  11.05216  27.80962  1.000 17.80820 ? 384  THR   A C   1 
ATOM   163  O O   . THR   A 1 29  ? 15.84784  10.83566  27.91093  1.000 20.75557 ? 384  THR   A O   1 
ATOM   164  C CB  . THR   A 1 29  ? 18.16120  11.95564  25.77529  1.000 30.66057 ? 384  THR   A CB  1 
ATOM   165  O OG1 . THR   A 1 29  ? 16.94208  12.55251  25.34574  1.000 29.04068 ? 384  THR   A OG1 1 
ATOM   166  C CG2 . THR   A 1 29  ? 19.01124  11.63014  24.51413  1.000 31.91186 ? 384  THR   A CG2 1 
ATOM   167  N N   . VAL   A 1 30  ? 17.77572  11.60800  28.77420  1.000 18.85487 ? 385  VAL   A N   1 
ATOM   168  C CA  . VAL   A 1 30  ? 17.19169  12.23045  29.95975  1.000 16.38127 ? 385  VAL   A CA  1 
ATOM   169  C C   . VAL   A 1 30  ? 17.58500  13.69243  29.91991  1.000 19.09946 ? 385  VAL   A C   1 
ATOM   170  O O   . VAL   A 1 30  ? 18.77238  14.00804  29.77735  1.000 20.90862 ? 385  VAL   A O   1 
ATOM   171  C CB  . VAL   A 1 30  ? 17.68949  11.59269  31.26817  1.000 18.16907 ? 385  VAL   A CB  1 
ATOM   172  C CG1 . VAL   A 1 30  ? 17.11968  12.37688  32.45282  1.000 22.07734 ? 385  VAL   A CG1 1 
ATOM   173  C CG2 . VAL   A 1 30  ? 17.24107  10.12016  31.34322  1.000 25.09372 ? 385  VAL   A CG2 1 
ATOM   174  N N   . LYS   A 1 31  ? 16.60097  14.57233  30.08993  1.000 17.55644 ? 386  LYS   A N   1 
ATOM   175  C CA  . LYS   A 1 31  ? 16.82883  16.01002  30.10641  1.000 19.74610 ? 386  LYS   A CA  1 
ATOM   176  C C   . LYS   A 1 31  ? 16.19259  16.61043  31.33526  1.000 17.76816 ? 386  LYS   A C   1 
ATOM   177  O O   . LYS   A 1 31  ? 15.19641  16.09304  31.84676  1.000 18.66295 ? 386  LYS   A O   1 
ATOM   178  C CB  . LYS   A 1 31  ? 16.22942  16.71009  28.85901  1.000 21.61234 ? 386  LYS   A CB  1 
ATOM   179  C CG  . LYS   A 1 31  ? 16.95333  16.37973  27.56975  1.000 23.96956 ? 386  LYS   A CG  1 
ATOM   180  C CD  . LYS   A 1 31  ? 16.48568  17.37313  26.51025  1.000 27.35164 ? 386  LYS   A CD  1 
ATOM   181  C CE  . LYS   A 1 31  ? 17.38942  17.35294  25.30993  1.000 39.48334 ? 386  LYS   A CE  1 
ATOM   182  N NZ  . LYS   A 1 31  ? 16.92417  18.39189  24.35978  1.000 37.76337 ? 386  LYS   A NZ  1 
ATOM   183  N N   . LYS   A 1 32  ? 16.79180  17.69836  31.80229  1.000 18.06160 ? 387  LYS   A N   1 
ATOM   184  C CA  . LYS   A 1 32  ? 16.18308  18.51791  32.83870  1.000 14.27790 ? 387  LYS   A CA  1 
ATOM   185  C C   . LYS   A 1 32  ? 15.13772  19.42809  32.21384  1.000 17.53323 ? 387  LYS   A C   1 
ATOM   186  O O   . LYS   A 1 32  ? 15.29027  19.88825  31.07127  1.000 19.52011 ? 387  LYS   A O   1 
ATOM   187  C CB  . LYS   A 1 32  ? 17.26891  19.37441  33.49767  1.000 18.05274 ? 387  LYS   A CB  1 
ATOM   188  C CG  . LYS   A 1 32  ? 16.76228  20.28833  34.56206  1.000 18.43698 ? 387  LYS   A CG  1 
ATOM   189  C CD  . LYS   A 1 32  ? 17.99111  20.78984  35.36338  1.000 21.60260 ? 387  LYS   A CD  1 
ATOM   190  C CE  . LYS   A 1 32  ? 17.59391  21.42003  36.66742  1.000 25.02722 ? 387  LYS   A CE  1 
ATOM   191  N NZ  . LYS   A 1 32  ? 18.86687  21.80551  37.40148  1.000 20.07274 ? 387  LYS   A NZ  1 
ATOM   192  N N   . GLY   A 1 33  ? 14.07995  19.69253  32.95642  1.000 16.23496 ? 388  GLY   A N   1 
ATOM   193  C CA  . GLY   A 1 33  ? 13.13623  20.69776  32.50310  1.000 19.19581 ? 388  GLY   A CA  1 
ATOM   194  C C   . GLY   A 1 33  ? 12.36283  21.29161  33.65901  1.000 15.99806 ? 388  GLY   A C   1 
ATOM   195  O O   . GLY   A 1 33  ? 12.65862  21.03773  34.82926  1.000 15.34103 ? 388  GLY   A O   1 
ATOM   196  N N   . TYR   A 1 34  ? 11.32142  22.04908  33.29449  1.000 16.53649 ? 389  TYR   A N   1 
ATOM   197  C CA  . TYR   A 1 34  ? 10.42080  22.67612  34.24252  1.000 18.11548 ? 389  TYR   A CA  1 
ATOM   198  C C   . TYR   A 1 34  ? 9.00752   22.45101  33.79877  1.000 21.81349 ? 389  TYR   A C   1 
ATOM   199  O O   . TYR   A 1 34  ? 8.70554   22.56330  32.60892  1.000 26.07225 ? 389  TYR   A O   1 
ATOM   200  C CB  . TYR   A 1 34  ? 10.64915  24.18544  34.30889  1.000 21.58675 ? 389  TYR   A CB  1 
ATOM   201  C CG  . TYR   A 1 34  ? 11.99679  24.46140  34.81343  1.000 21.91482 ? 389  TYR   A CG  1 
ATOM   202  C CD1 . TYR   A 1 34  ? 13.06740  24.55568  33.93940  1.000 21.25773 ? 389  TYR   A CD1 1 
ATOM   203  C CD2 . TYR   A 1 34  ? 12.22729  24.48036  36.16583  1.000 23.35004 ? 389  TYR   A CD2 1 
ATOM   204  C CE1 . TYR   A 1 34  ? 14.36674  24.72806  34.41314  1.000 30.07223 ? 389  TYR   A CE1 1 
ATOM   205  C CE2 . TYR   A 1 34  ? 13.51204  24.66710  36.64290  1.000 20.35367 ? 389  TYR   A CE2 1 
ATOM   206  C CZ  . TYR   A 1 34  ? 14.55995  24.79115  35.77262  1.000 25.93357 ? 389  TYR   A CZ  1 
ATOM   207  O OH  . TYR   A 1 34  ? 15.82828  24.96578  36.28972  1.000 38.12152 ? 389  TYR   A OH  1 
ATOM   208  N N   . TYR   A 1 35  ? 8.13811   22.18522  34.75701  1.000 18.36785 ? 390  TYR   A N   1 
ATOM   209  C CA  . TYR   A 1 35  ? 6.71219   22.07171  34.50325  1.000 19.76023 ? 390  TYR   A CA  1 
ATOM   210  C C   . TYR   A 1 35  ? 5.99483   23.13636  35.30043  1.000 19.77681 ? 390  TYR   A C   1 
ATOM   211  O O   . TYR   A 1 35  ? 6.10866   23.19427  36.54113  1.000 18.75172 ? 390  TYR   A O   1 
ATOM   212  C CB  . TYR   A 1 35  ? 6.15916   20.68237  34.83663  1.000 20.49963 ? 390  TYR   A CB  1 
ATOM   213  C CG  . TYR   A 1 35  ? 4.83786   20.47521  34.11033  1.000 21.67186 ? 390  TYR   A CG  1 
ATOM   214  C CD1 . TYR   A 1 35  ? 4.80457   20.31561  32.72295  1.000 23.93306 ? 390  TYR   A CD1 1 
ATOM   215  C CD2 . TYR   A 1 35  ? 3.65049   20.51315  34.78730  1.000 22.24206 ? 390  TYR   A CD2 1 
ATOM   216  C CE1 . TYR   A 1 35  ? 3.60043   20.15806  32.03457  1.000 24.65678 ? 390  TYR   A CE1 1 
ATOM   217  C CE2 . TYR   A 1 35  ? 2.41043   20.33138  34.09849  1.000 21.86706 ? 390  TYR   A CE2 1 
ATOM   218  C CZ  . TYR   A 1 35  ? 2.42982   20.18434  32.72561  1.000 25.87655 ? 390  TYR   A CZ  1 
ATOM   219  O OH  . TYR   A 1 35  ? 1.25737   20.01171  32.00418  1.000 30.41467 ? 390  TYR   A OH  1 
ATOM   220  N N   . GLN   A 1 36  ? 5.21918   23.95793  34.60366  1.000 18.18120 ? 391  GLN   A N   1 
ATOM   221  C CA  . GLN   A 1 36  ? 4.51489   25.04775  35.26482  1.000 20.46355 ? 391  GLN   A CA  1 
ATOM   222  C C   . GLN   A 1 36  ? 3.25831   24.52262  35.96092  1.000 28.88539 ? 391  GLN   A C   1 
ATOM   223  O O   . GLN   A 1 36  ? 2.29914   24.09860  35.29175  1.000 26.94004 ? 391  GLN   A O   1 
ATOM   224  C CB  . GLN   A 1 36  ? 4.18229   26.09971  34.21910  1.000 24.33083 ? 391  GLN   A CB  1 
ATOM   225  C CG  . GLN   A 1 36  ? 3.36795   27.24484  34.74543  1.000 28.97750 ? 391  GLN   A CG  1 
ATOM   226  C CD  . GLN   A 1 36  ? 4.13310   28.01870  35.78862  1.000 31.31964 ? 391  GLN   A CD  1 
ATOM   227  O OE1 . GLN   A 1 36  ? 5.25620   28.50381  35.54898  1.000 32.47071 ? 391  GLN   A OE1 1 
ATOM   228  N NE2 . GLN   A 1 36  ? 3.56820   28.06713  36.97725  1.000 26.51166 ? 391  GLN   A NE2 1 
ATOM   229  N N   . MET   A 1 37  ? 3.25013   24.55032  37.30105  1.000 26.50531 ? 392  MET   A N   1 
ATOM   230  C CA  . MET   A 1 37  ? 2.04607   24.27459  38.07314  1.000 28.37107 ? 392  MET   A CA  1 
ATOM   231  C C   . MET   A 1 37  ? 1.16896   25.52738  38.13764  1.000 24.22323 ? 392  MET   A C   1 
ATOM   232  O O   . MET   A 1 37  ? 1.37753   26.52091  37.42941  1.000 33.19127 ? 392  MET   A O   1 
ATOM   233  C CB  . MET   A 1 37  ? 2.39496   23.79075  39.47282  1.000 31.28329 ? 392  MET   A CB  1 
ATOM   234  C CG  . MET   A 1 37  ? 3.28438   22.58618  39.51903  1.000 25.47838 ? 392  MET   A CG  1 
ATOM   235  S SD  . MET   A 1 37  ? 2.54357   21.25306  38.62397  1.000 53.38854 ? 392  MET   A SD  1 
ATOM   236  C CE  . MET   A 1 37  ? 3.90689   20.12372  38.63141  1.000 29.61042 ? 392  MET   A CE  1 
ATOM   237  N N   . LYS   A 1 38  ? 0.19650   25.50818  39.04619  1.000 35.46887 ? 393  LYS   A N   1 
ATOM   238  C CA  . LYS   A 1 38  ? -0.72974  26.63457  39.11630  1.000 38.83180 ? 393  LYS   A CA  1 
ATOM   239  C C   . LYS   A 1 38  ? -0.00217  27.92709  39.48495  1.000 39.74166 ? 393  LYS   A C   1 
ATOM   240  O O   . LYS   A 1 38  ? -0.24574  28.97950  38.87837  1.000 41.76552 ? 393  LYS   A O   1 
ATOM   241  C CB  . LYS   A 1 38  ? -1.85817  26.31766  40.09789  1.000 39.74101 ? 393  LYS   A CB  1 
ATOM   242  C CG  . LYS   A 1 38  ? -2.46819  24.90561  39.90957  1.000 49.23490 ? 393  LYS   A CG  1 
ATOM   243  C CD  . LYS   A 1 38  ? -2.73399  24.56911  38.42313  1.000 60.75889 ? 393  LYS   A CD  1 
ATOM   244  C CE  . LYS   A 1 38  ? -3.50431  23.25964  38.23461  1.000 43.51784 ? 393  LYS   A CE  1 
ATOM   245  N NZ  . LYS   A 1 38  ? -4.84011  23.35790  38.89467  1.000 49.56213 ? 393  LYS   A NZ  1 
ATOM   246  N N   . LYS   A 1 39  ? 0.94731   27.85499  40.42491  1.000 34.97469 ? 394  LYS   A N   1 
ATOM   247  C CA  . LYS   A 1 39  ? 1.77916   29.01018  40.74471  1.000 31.68489 ? 394  LYS   A CA  1 
ATOM   248  C C   . LYS   A 1 39  ? 3.26291   28.63290  40.64440  1.000 19.04382 ? 394  LYS   A C   1 
ATOM   249  O O   . LYS   A 1 39  ? 4.01475   29.26497  39.88892  1.000 26.29106 ? 394  LYS   A O   1 
ATOM   250  C CB  . LYS   A 1 39  ? 1.42336   29.52411  42.14249  1.000 31.69109 ? 394  LYS   A CB  1 
ATOM   251  C CG  . LYS   A 1 39  ? 2.29380   30.66020  42.64937  1.000 36.00124 ? 394  LYS   A CG  1 
ATOM   252  C CD  . LYS   A 1 39  ? 1.59106   31.47886  43.72861  1.000 27.12902 ? 394  LYS   A CD  1 
ATOM   253  C CE  . LYS   A 1 39  ? 1.18563   30.66484  44.92067  1.000 25.61388 ? 394  LYS   A CE  1 
ATOM   254  N NZ  . LYS   A 1 39  ? 0.50445   31.55925  45.92570  1.000 21.48189 ? 394  LYS   A NZ  1 
ATOM   255  N N   . VAL   A 1 40  ? 3.64714   27.60290  41.37168  1.000 26.33164 ? 395  VAL   A N   1 
ATOM   256  C CA  . VAL   A 1 40  ? 5.05690   27.22841  41.43804  1.000 21.68583 ? 395  VAL   A CA  1 
ATOM   257  C C   . VAL   A 1 40  ? 5.45133   26.52575  40.15555  1.000 25.60902 ? 395  VAL   A C   1 
ATOM   258  O O   . VAL   A 1 40  ? 4.61068   25.97440  39.42713  1.000 25.42767 ? 395  VAL   A O   1 
ATOM   259  C CB  . VAL   A 1 40  ? 5.35253   26.35247  42.66324  1.000 18.17245 ? 395  VAL   A CB  1 
ATOM   260  C CG1 . VAL   A 1 40  ? 4.91741   27.07372  43.95879  1.000 23.74774 ? 395  VAL   A CG1 1 
ATOM   261  C CG2 . VAL   A 1 40  ? 4.75205   24.94506  42.52639  1.000 24.83908 ? 395  VAL   A CG2 1 
ATOM   262  N N   . VAL   A 1 41  ? 6.72969   26.59234  39.84481  1.000 18.24425 ? 396  VAL   A N   1 
ATOM   263  C CA  . VAL   A 1 41  ? 7.26772   25.70935  38.82010  1.000 17.33705 ? 396  VAL   A CA  1 
ATOM   264  C C   . VAL   A 1 41  ? 7.92480   24.52841  39.51640  1.000 18.40976 ? 396  VAL   A C   1 
ATOM   265  O O   . VAL   A 1 41  ? 8.42918   24.62699  40.62953  1.000 16.39185 ? 396  VAL   A O   1 
ATOM   266  C CB  . VAL   A 1 41  ? 8.21939   26.45779  37.84856  1.000 20.73931 ? 396  VAL   A CB  1 
ATOM   267  C CG1 . VAL   A 1 41  ? 9.55553   26.77870  38.44537  1.000 24.25187 ? 396  VAL   A CG1 1 
ATOM   268  C CG2 . VAL   A 1 41  ? 8.44442   25.69688  36.63324  1.000 30.45105 ? 396  VAL   A CG2 1 
ATOM   269  N N   . LYS   A 1 42  ? 7.82930   23.36530  38.89223  1.000 15.51949 ? 397  LYS   A N   1 
ATOM   270  C CA  . LYS   A 1 42  ? 8.44996   22.14683  39.38973  1.000 14.40389 ? 397  LYS   A CA  1 
ATOM   271  C C   . LYS   A 1 42  ? 9.59471   21.73561  38.48491  1.000 14.71548 ? 397  LYS   A C   1 
ATOM   272  O O   . LYS   A 1 42  ? 9.43196   21.61540  37.26196  1.000 15.79574 ? 397  LYS   A O   1 
ATOM   273  C CB  . LYS   A 1 42  ? 7.40759   21.03022  39.46478  1.000 19.19833 ? 397  LYS   A CB  1 
ATOM   274  C CG  . LYS   A 1 42  ? 7.85656   19.86244  40.29387  1.000 31.62044 ? 397  LYS   A CG  1 
ATOM   275  C CD  . LYS   A 1 42  ? 6.65279   19.22575  40.96229  1.000 35.97036 ? 397  LYS   A CD  1 
ATOM   276  C CE  . LYS   A 1 42  ? 7.03468   17.94357  41.62958  1.000 31.57647 ? 397  LYS   A CE  1 
ATOM   277  N NZ  . LYS   A 1 42  ? 7.86024   18.11624  42.85980  1.000 32.14359 ? 397  LYS   A NZ  1 
ATOM   278  N N   . THR   A 1 43  ? 10.76618  21.52319  39.07132  1.000 12.17972 ? 398  THR   A N   1 
ATOM   279  C CA  . THR   A 1 43  ? 11.89882  21.00976  38.31521  1.000 13.65970 ? 398  THR   A CA  1 
ATOM   280  C C   . THR   A 1 43  ? 11.65023  19.52747  38.03976  1.000 15.31699 ? 398  THR   A C   1 
ATOM   281  O O   . THR   A 1 43  ? 11.28558  18.76726  38.94990  1.000 15.40393 ? 398  THR   A O   1 
ATOM   282  C CB  . THR   A 1 43  ? 13.17223  21.13603  39.13884  1.000 14.71587 ? 398  THR   A CB  1 
ATOM   283  O OG1 . THR   A 1 43  ? 13.33478  22.51480  39.55590  1.000 17.43810 ? 398  THR   A OG1 1 
ATOM   284  C CG2 . THR   A 1 43  ? 14.37636  20.86821  38.30857  1.000 14.21203 ? 398  THR   A CG2 1 
ATOM   285  N N   . VAL   A 1 44  ? 11.82659  19.12186  36.78176  1.000 13.03406 ? 399  VAL   A N   1 
ATOM   286  C CA  . VAL   A 1 44  ? 11.53522  17.75478  36.37932  1.000 12.16861 ? 399  VAL   A CA  1 
ATOM   287  C C   . VAL   A 1 44  ? 12.69938  17.13566  35.62720  1.000 13.31326 ? 399  VAL   A C   1 
ATOM   288  O O   . VAL   A 1 44  ? 13.56472  17.80308  35.06647  1.000 13.51926 ? 399  VAL   A O   1 
ATOM   289  C CB  . VAL   A 1 44  ? 10.27264  17.67716  35.50679  1.000 12.71255 ? 399  VAL   A CB  1 
ATOM   290  C CG1 . VAL   A 1 44  ? 9.06013   18.05384  36.34802  1.000 14.51449 ? 399  VAL   A CG1 1 
ATOM   291  C CG2 . VAL   A 1 44  ? 10.37914  18.56887  34.23973  1.000 16.31426 ? 399  VAL   A CG2 1 
ATOM   292  N N   . ALA   A 1 45  ? 12.72224  15.80667  35.66634  1.000 11.81332 ? 400  ALA   A N   1 
ATOM   293  C CA  . ALA   A 1 45  ? 13.61346  15.01922  34.84704  1.000 11.25828 ? 400  ALA   A CA  1 
ATOM   294  C C   . ALA   A 1 45  ? 12.73007  14.35542  33.80682  1.000 14.27311 ? 400  ALA   A C   1 
ATOM   295  O O   . ALA   A 1 45  ? 11.66584  13.85295  34.13913  1.000 14.64232 ? 400  ALA   A O   1 
ATOM   296  C CB  . ALA   A 1 45  ? 14.35480  13.95749  35.67956  1.000 16.96052 ? 400  ALA   A CB  1 
ATOM   297  N N   . VAL   A 1 46  ? 13.16989  14.35592  32.56969  1.000 16.92313 ? 401  VAL   A N   1 
ATOM   298  C CA  . VAL   A 1 46  ? 12.28625  13.94563  31.47943  1.000 13.11618 ? 401  VAL   A CA  1 
ATOM   299  C C   . VAL   A 1 46  ? 12.99259  12.86810  30.67091  1.000 13.73526 ? 401  VAL   A C   1 
ATOM   300  O O   . VAL   A 1 46  ? 14.06964  13.11639  30.11760  1.000 16.06030 ? 401  VAL   A O   1 
ATOM   301  C CB  . VAL   A 1 46  ? 11.91932  15.12688  30.56464  1.000 13.91509 ? 401  VAL   A CB  1 
ATOM   302  C CG1 . VAL   A 1 46  ? 10.83692  14.68830  29.50947  1.000 17.74996 ? 401  VAL   A CG1 1 
ATOM   303  C CG2 . VAL   A 1 46  ? 11.36661  16.30762  31.39727  1.000 16.72975 ? 401  VAL   A CG2 1 
ATOM   304  N N   . LYS   A 1 47  ? 12.38458  11.67990  30.60335  1.000 13.03957 ? 402  LYS   A N   1 
ATOM   305  C CA  . LYS   A 1 47  ? 12.89300  10.61618  29.73904  1.000 15.96274 ? 402  LYS   A CA  1 
ATOM   306  C C   . LYS   A 1 47  ? 12.26765  10.79434  28.35364  1.000 14.64806 ? 402  LYS   A C   1 
ATOM   307  O O   . LYS   A 1 47  ? 11.04727  10.78806  28.21863  1.000 15.42442 ? 402  LYS   A O   1 
ATOM   308  C CB  . LYS   A 1 47  ? 12.54154  9.25408   30.34762  1.000 16.94870 ? 402  LYS   A CB  1 
ATOM   309  C CG  . LYS   A 1 47  ? 12.80570  8.03962   29.42689  1.000 19.40365 ? 402  LYS   A CG  1 
ATOM   310  C CD  . LYS   A 1 47  ? 12.61361  6.71480   30.24394  1.000 19.73749 ? 402  LYS   A CD  1 
ATOM   311  C CE  . LYS   A 1 47  ? 12.81575  5.50245   29.34600  1.000 25.46807 ? 402  LYS   A CE  1 
ATOM   312  N NZ  . LYS   A 1 47  ? 12.62131  4.32707   30.22342  1.000 23.65877 ? 402  LYS   A NZ  1 
ATOM   313  N N   . ILE   A 1 48  ? 13.11480  10.96193  27.34930  1.000 17.62848 ? 403  ILE   A N   1 
ATOM   314  C CA  . ILE   A 1 48  ? 12.68074  11.27870  25.99498  1.000 16.20693 ? 403  ILE   A CA  1 
ATOM   315  C C   . ILE   A 1 48  ? 13.05608  10.11366  25.09178  1.000 19.17514 ? 403  ILE   A C   1 
ATOM   316  O O   . ILE   A 1 48  ? 14.24311  9.79806   24.94597  1.000 21.32285 ? 403  ILE   A O   1 
ATOM   317  C CB  . ILE   A 1 48  ? 13.30793  12.58246  25.51017  1.000 18.55660 ? 403  ILE   A CB  1 
ATOM   318  C CG1 . ILE   A 1 48  ? 12.93375  13.70198  26.48326  1.000 21.29010 ? 403  ILE   A CG1 1 
ATOM   319  C CG2 . ILE   A 1 48  ? 12.80256  12.88118  24.08769  1.000 22.41910 ? 403  ILE   A CG2 1 
ATOM   320  C CD1 . ILE   A 1 48  ? 13.64707  15.00596  26.22289  1.000 28.96320 ? 403  ILE   A CD1 1 
ATOM   321  N N   . LEU   A 1 49  ? 12.05996  9.51345   24.45638  1.000 20.39487 ? 404  LEU   A N   1 
ATOM   322  C CA  . LEU   A 1 49  ? 12.35797  8.38801   23.56658  1.000 25.01695 ? 404  LEU   A CA  1 
ATOM   323  C C   . LEU   A 1 49  ? 13.05735  8.83177   22.27976  1.000 25.29404 ? 404  LEU   A C   1 
ATOM   324  O O   . LEU   A 1 49  ? 12.81915  9.92123   21.75522  1.000 28.79311 ? 404  LEU   A O   1 
ATOM   325  C CB  . LEU   A 1 49  ? 11.08167  7.65009   23.20516  1.000 23.07515 ? 404  LEU   A CB  1 
ATOM   326  C CG  . LEU   A 1 49  ? 10.36964  6.95105   24.34454  1.000 26.31149 ? 404  LEU   A CG  1 
ATOM   327  C CD1 . LEU   A 1 49  ? 9.26215   6.06371   23.74175  1.000 31.13097 ? 404  LEU   A CD1 1 
ATOM   328  C CD2 . LEU   A 1 49  ? 11.34022  6.12668   25.18689  1.000 28.84801 ? 404  LEU   A CD2 1 
ATOM   329  N N   . LYS   A 1 50  ? 13.95235  7.98146   21.78333  1.000 29.37608 ? 405  LYS   A N   1 
ATOM   330  C CA  . LYS   A 1 50  ? 14.53974  8.23241   20.47439  1.000 34.33970 ? 405  LYS   A CA  1 
ATOM   331  C C   . LYS   A 1 50  ? 13.86021  7.31106   19.47986  1.000 46.38598 ? 405  LYS   A C   1 
ATOM   332  O O   . LYS   A 1 50  ? 13.69454  6.12822   19.76597  1.000 57.11715 ? 405  LYS   A O   1 
ATOM   333  C CB  . LYS   A 1 50  ? 16.05177  8.00977   20.47083  1.000 43.67008 ? 405  LYS   A CB  1 
ATOM   334  C CG  . LYS   A 1 50  ? 16.75257  8.82741   19.40376  1.000 50.90508 ? 405  LYS   A CG  1 
ATOM   335  C CD  . LYS   A 1 50  ? 16.17335  10.23935  19.35178  1.000 57.99184 ? 405  LYS   A CD  1 
ATOM   336  C CE  . LYS   A 1 50  ? 16.81559  11.08186  18.27037  1.000 58.35523 ? 405  LYS   A CE  1 
ATOM   337  N NZ  . LYS   A 1 50  ? 16.21926  12.44880  18.23196  1.000 66.36690 ? 405  LYS   A NZ  1 
ATOM   338  N N   . PRO   A 1 56  ? 7.68472   1.48974   17.69894  1.000 49.73627 ? 411  PRO   A N   1 
ATOM   339  C CA  . PRO   A 1 56  ? 6.49800   0.72324   18.10371  1.000 43.48967 ? 411  PRO   A CA  1 
ATOM   340  C C   . PRO   A 1 56  ? 6.61528   0.18517   19.54615  1.000 48.29990 ? 411  PRO   A C   1 
ATOM   341  O O   . PRO   A 1 56  ? 5.82327   0.51809   20.43954  1.000 46.08332 ? 411  PRO   A O   1 
ATOM   342  C CB  . PRO   A 1 56  ? 6.46288   -0.41986  17.08163  1.000 44.34665 ? 411  PRO   A CB  1 
ATOM   343  C CG  . PRO   A 1 56  ? 7.87867   -0.55828  16.62902  1.000 43.78054 ? 411  PRO   A CG  1 
ATOM   344  C CD  . PRO   A 1 56  ? 8.45952   0.81222   16.64416  1.000 42.04967 ? 411  PRO   A CD  1 
ATOM   345  N N   . ALA   A 1 57  ? 7.64711   -0.63263  19.76106  1.000 47.08011 ? 412  ALA   A N   1 
ATOM   346  C CA  . ALA   A 1 57  ? 7.84170   -1.28810  21.04780  1.000 38.02244 ? 412  ALA   A CA  1 
ATOM   347  C C   . ALA   A 1 57  ? 8.23953   -0.29275  22.13050  1.000 44.37510 ? 412  ALA   A C   1 
ATOM   348  O O   . ALA   A 1 57  ? 7.77114   -0.39825  23.27127  1.000 41.00446 ? 412  ALA   A O   1 
ATOM   349  C CB  . ALA   A 1 57  ? 8.90177   -2.38332  20.91469  1.000 41.42578 ? 412  ALA   A CB  1 
ATOM   350  N N   . LEU   A 1 58  ? 9.11663   0.66773   21.79736  1.000 41.03920 ? 413  LEU   A N   1 
ATOM   351  C CA  . LEU   A 1 58  ? 9.58059   1.64329   22.78380  1.000 44.20931 ? 413  LEU   A CA  1 
ATOM   352  C C   . LEU   A 1 58  ? 8.43643   2.49796   23.30771  1.000 34.24926 ? 413  LEU   A C   1 
ATOM   353  O O   . LEU   A 1 58  ? 8.38900   2.81229   24.50246  1.000 29.08226 ? 413  LEU   A O   1 
ATOM   354  C CB  . LEU   A 1 58  ? 10.66603  2.54140   22.18972  1.000 41.64031 ? 413  LEU   A CB  1 
ATOM   355  C CG  . LEU   A 1 58  ? 12.11000  2.06485   22.31423  1.000 47.91835 ? 413  LEU   A CG  1 
ATOM   356  C CD1 . LEU   A 1 58  ? 13.03905  3.11746   21.73613  1.000 56.48347 ? 413  LEU   A CD1 1 
ATOM   357  C CD2 . LEU   A 1 58  ? 12.45286  1.76743   23.77360  1.000 49.56788 ? 413  LEU   A CD2 1 
ATOM   358  N N   . LYS   A 1 59  ? 7.51211   2.89599   22.43304  1.000 33.17226 ? 414  LYS   A N   1 
ATOM   359  C CA  . LYS   A 1 59  ? 6.36910   3.67119   22.89177  1.000 33.19925 ? 414  LYS   A CA  1 
ATOM   360  C C   . LYS   A 1 59  ? 5.51700   2.86466   23.85264  1.000 34.57013 ? 414  LYS   A C   1 
ATOM   361  O O   . LYS   A 1 59  ? 5.13134   3.35514   24.91020  1.000 24.61898 ? 414  LYS   A O   1 
ATOM   362  C CB  . LYS   A 1 59  ? 5.53186   4.14079   21.70116  1.000 35.41800 ? 414  LYS   A CB  1 
ATOM   363  C CG  . LYS   A 1 59  ? 4.21734   4.78115   22.11551  1.000 34.01165 ? 414  LYS   A CG  1 
ATOM   364  C CD  . LYS   A 1 59  ? 3.24438   4.91014   20.95233  1.000 48.07827 ? 414  LYS   A CD  1 
ATOM   365  C CE  . LYS   A 1 59  ? 2.69197   3.55512   20.53030  1.000 54.57680 ? 414  LYS   A CE  1 
ATOM   366  N NZ  . LYS   A 1 59  ? 1.76346   2.97574   21.54087  1.000 51.46530 ? 414  LYS   A NZ  1 
ATOM   367  N N   . ASP   A 1 60  ? 5.19817   1.62085   23.49544  1.000 31.82162 ? 415  ASP   A N   1 
ATOM   368  C CA  . ASP   A 1 60  ? 4.37437   0.79949   24.37131  1.000 28.00888 ? 415  ASP   A CA  1 
ATOM   369  C C   . ASP   A 1 60  ? 5.03202   0.63412   25.73804  1.000 21.50895 ? 415  ASP   A C   1 
ATOM   370  O O   . ASP   A 1 60  ? 4.35607   0.71941   26.77213  1.000 23.77546 ? 415  ASP   A O   1 
ATOM   371  C CB  . ASP   A 1 60  ? 4.14089   -0.55730  23.72400  1.000 30.04799 ? 415  ASP   A CB  1 
ATOM   372  C CG  . ASP   A 1 60  ? 3.18681   -0.48721  22.55497  1.000 50.49006 ? 415  ASP   A CG  1 
ATOM   373  O OD1 . ASP   A 1 60  ? 2.54336   0.56722   22.37401  1.000 48.24685 ? 415  ASP   A OD1 1 
ATOM   374  O OD2 . ASP   A 1 60  ? 3.08480   -1.49420  21.82249  1.000 51.94661 ? 415  ASP   A OD2 1 
ATOM   375  N N   . GLU   A 1 61  ? 6.35715   0.44124   25.74037  1.000 22.70019 ? 416  GLU   A N   1 
ATOM   376  C CA  . GLU   A 1 61  ? 7.11966   0.25770   26.96682  1.000 21.71641 ? 416  GLU   A CA  1 
ATOM   377  C C   . GLU   A 1 61  ? 7.08704   1.51404   27.82550  1.000 21.36413 ? 416  GLU   A C   1 
ATOM   378  O O   . GLU   A 1 61  ? 6.93741   1.41936   29.04938  1.000 19.53405 ? 416  GLU   A O   1 
ATOM   379  C CB  . GLU   A 1 61  ? 8.55090   -0.12839  26.63263  1.000 30.29417 ? 416  GLU   A CB  1 
ATOM   380  C CG  . GLU   A 1 61  ? 8.63745   -1.56322  26.15153  1.000 35.45748 ? 416  GLU   A CG  1 
ATOM   381  C CD  . GLU   A 1 61  ? 9.84978   -1.80783  25.29424  1.000 47.67177 ? 416  GLU   A CD  1 
ATOM   382  O OE1 . GLU   A 1 61  ? 10.96061  -1.38886  25.68553  1.000 46.29094 ? 416  GLU   A OE1 1 
ATOM   383  O OE2 . GLU   A 1 61  ? 9.68789   -2.40717  24.21111  1.000 57.15870 ? 416  GLU   A OE2 1 
ATOM   384  N N   . LEU   A 1 62  ? 7.19267   2.70066   27.20499  1.000 21.65021 ? 417  LEU   A N   1 
ATOM   385  C CA  . LEU   A 1 62  ? 7.13534   3.93177   27.99516  1.000 18.09303 ? 417  LEU   A CA  1 
ATOM   386  C C   . LEU   A 1 62  ? 5.75645   4.12343   28.61035  1.000 20.30390 ? 417  LEU   A C   1 
ATOM   387  O O   . LEU   A 1 62  ? 5.63783   4.54968   29.77132  1.000 19.43792 ? 417  LEU   A O   1 
ATOM   388  C CB  . LEU   A 1 62  ? 7.50856   5.14612   27.13101  1.000 19.02355 ? 417  LEU   A CB  1 
ATOM   389  C CG  . LEU   A 1 62  ? 7.79760   6.44183   27.91295  1.000 19.60128 ? 417  LEU   A CG  1 
ATOM   390  C CD1 . LEU   A 1 62  ? 9.15893   6.29591   28.50085  1.000 23.50566 ? 417  LEU   A CD1 1 
ATOM   391  C CD2 . LEU   A 1 62  ? 7.81117   7.68067   27.00038  1.000 20.55722 ? 417  LEU   A CD2 1 
ATOM   392  N N   . LEU   A 1 63  ? 4.68253   3.82985   27.84384  1.000 19.37022 ? 418  LEU   A N   1 
ATOM   393  C CA  . LEU   A 1 63  ? 3.33805   3.94116   28.38431  1.000 20.36767 ? 418  LEU   A CA  1 
ATOM   394  C C   . LEU   A 1 63  ? 3.11659   2.96865   29.53950  1.000 18.58227 ? 418  LEU   A C   1 
ATOM   395  O O   . LEU   A 1 63  ? 2.43596   3.30407   30.50912  1.000 20.16754 ? 418  LEU   A O   1 
ATOM   396  C CB  . LEU   A 1 63  ? 2.30870   3.71413   27.26676  1.000 21.50311 ? 418  LEU   A CB  1 
ATOM   397  C CG  . LEU   A 1 63  ? 2.28492   4.81974   26.18639  1.000 28.22879 ? 418  LEU   A CG  1 
ATOM   398  C CD1 . LEU   A 1 63  ? 1.14253   4.55514   25.21464  1.000 29.87555 ? 418  LEU   A CD1 1 
ATOM   399  C CD2 . LEU   A 1 63  ? 2.19074   6.27541   26.69801  1.000 26.38385 ? 418  LEU   A CD2 1 
ATOM   400  N N   . ALA   A 1 64  ? 3.68097   1.76039   29.45029  1.000 21.29734 ? 419  ALA   A N   1 
ATOM   401  C CA  . ALA   A 1 64  ? 3.51450   0.78698   30.53579  1.000 19.51814 ? 419  ALA   A CA  1 
ATOM   402  C C   . ALA   A 1 64  ? 4.29828   1.22478   31.76389  1.000 16.75491 ? 419  ALA   A C   1 
ATOM   403  O O   . ALA   A 1 64  ? 3.79024   1.12581   32.88477  1.000 19.09320 ? 419  ALA   A O   1 
ATOM   404  C CB  . ALA   A 1 64  ? 3.96624   -0.60532  30.07517  1.000 19.22376 ? 419  ALA   A CB  1 
ATOM   405  N N   . GLU   A 1 65  ? 5.51061   1.75821   31.54793  1.000 17.13268 ? 420  GLU   A N   1 
ATOM   406  C CA  . GLU   A 1 65  ? 6.31433   2.32742   32.63079  1.000 18.12218 ? 420  GLU   A CA  1 
ATOM   407  C C   . GLU   A 1 65  ? 5.56032   3.43728   33.33099  1.000 18.41127 ? 420  GLU   A C   1 
ATOM   408  O O   . GLU   A 1 65  ? 5.51047   3.49927   34.56283  1.000 17.25050 ? 420  GLU   A O   1 
ATOM   409  C CB  . GLU   A 1 65  ? 7.62308   2.82879   32.03805  1.000 16.25119 ? 420  GLU   A CB  1 
ATOM   410  C CG  . GLU   A 1 65  ? 8.61739   3.45045   33.01065  1.000 17.89425 ? 420  GLU   A CG  1 
ATOM   411  C CD  . GLU   A 1 65  ? 9.93401   3.83507   32.33081  1.000 18.43208 ? 420  GLU   A CD  1 
ATOM   412  O OE1 . GLU   A 1 65  ? 10.02537  3.67119   31.09715  1.000 22.05619 ? 420  GLU   A OE1 1 
ATOM   413  O OE2 . GLU   A 1 65  ? 10.90567  4.28368   33.02010  1.000 18.51485 ? 420  GLU   A OE2 1 
ATOM   414  N N   . ALA   A 1 66  ? 4.94423   4.33437   32.56215  1.000 15.79446 ? 421  ALA   A N   1 
ATOM   415  C CA  . ALA   A 1 66  ? 4.19504   5.40129   33.20688  1.000 16.34858 ? 421  ALA   A CA  1 
ATOM   416  C C   . ALA   A 1 66  ? 2.98067   4.86772   33.95097  1.000 16.05728 ? 421  ALA   A C   1 
ATOM   417  O O   . ALA   A 1 66  ? 2.63787   5.36372   35.03630  1.000 20.54682 ? 421  ALA   A O   1 
ATOM   418  C CB  . ALA   A 1 66  ? 3.76420   6.40975   32.13147  1.000 19.62553 ? 421  ALA   A CB  1 
ATOM   419  N N   . ASN   A 1 67  ? 2.31387   3.86514   33.38413  1.000 17.13734 ? 422  ASN   A N   1 
ATOM   420  C CA  . ASN   A 1 67  ? 1.17021   3.28081   34.06051  1.000 21.79843 ? 422  ASN   A CA  1 
ATOM   421  C C   . ASN   A 1 67  ? 1.55752   2.65879   35.40688  1.000 20.80445 ? 422  ASN   A C   1 
ATOM   422  O O   . ASN   A 1 67  ? 0.81789   2.80515   36.38730  1.000 24.31293 ? 422  ASN   A O   1 
ATOM   423  C CB  . ASN   A 1 67  ? 0.52180   2.24565   33.15501  1.000 22.45631 ? 422  ASN   A CB  1 
ATOM   424  C CG  . ASN   A 1 67  ? -0.70544  1.63241   33.77632  1.000 34.63284 ? 422  ASN   A CG  1 
ATOM   425  O OD1 . ASN   A 1 67  ? -0.64919  0.52090   34.32776  1.000 39.76758 ? 422  ASN   A OD1 1 
ATOM   426  N ND2 . ASN   A 1 67  ? -1.81911  2.35743   33.72044  1.000 36.39722 ? 422  ASN   A ND2 1 
ATOM   427  N N   . VAL   A 1 68  ? 2.70556   1.95806   35.48242  1.000 18.33935 ? 423  VAL   A N   1 
ATOM   428  C CA  . VAL   A 1 68  ? 3.19798   1.50966   36.78859  1.000 18.37164 ? 423  VAL   A CA  1 
ATOM   429  C C   . VAL   A 1 68  ? 3.41012   2.69342   37.73395  1.000 18.30432 ? 423  VAL   A C   1 
ATOM   430  O O   . VAL   A 1 68  ? 2.94826   2.69712   38.87693  1.000 18.21732 ? 423  VAL   A O   1 
ATOM   431  C CB  . VAL   A 1 68  ? 4.49411   0.68863   36.65351  1.000 17.00583 ? 423  VAL   A CB  1 
ATOM   432  C CG1 . VAL   A 1 68  ? 5.03694   0.36485   38.05213  1.000 19.62762 ? 423  VAL   A CG1 1 
ATOM   433  C CG2 . VAL   A 1 68  ? 4.22033   -0.62125  35.92128  1.000 18.74879 ? 423  VAL   A CG2 1 
ATOM   434  N N   . MET   A 1 69  ? 4.15845   3.69537   37.30001  1.000 16.35441 ? 424  MET   A N   1 
ATOM   435  C CA  . MET   A 1 69  ? 4.52989   4.76658   38.23875  1.000 15.04164 ? 424  MET   A CA  1 
ATOM   436  C C   . MET   A 1 69  ? 3.31857   5.53703   38.75416  1.000 19.10980 ? 424  MET   A C   1 
ATOM   437  O O   . MET   A 1 69  ? 3.31727   6.00493   39.89497  1.000 20.19977 ? 424  MET   A O   1 
ATOM   438  C CB  . MET   A 1 69  ? 5.49600   5.72734   37.56847  1.000 17.57783 ? 424  MET   A CB  1 
ATOM   439  C CG  . MET   A 1 69  ? 6.84593   5.11705   37.14183  1.000 19.05973 ? 424  MET   A CG  1 
ATOM   440  S SD  . MET   A 1 69  ? 7.96804   6.33893   36.49805  1.000 18.38752 ? 424  MET   A SD  1 
ATOM   441  C CE  . MET   A 1 69  ? 8.55699   7.10206   37.99699  1.000 17.40466 ? 424  MET   A CE  1 
ATOM   442  N N   . GLN   A 1 70  ? 2.30034   5.70326   37.90950  1.000 19.72548 ? 425  GLN   A N   1 
ATOM   443  C CA  . GLN   A 1 70  ? 1.08490   6.41453   38.30196  1.000 22.34444 ? 425  GLN   A CA  1 
ATOM   444  C C   . GLN   A 1 70  ? 0.35794   5.73417   39.45570  1.000 21.94027 ? 425  GLN   A C   1 
ATOM   445  O O   . GLN   A 1 70  ? -0.35393  6.39918   40.21429  1.000 24.76870 ? 425  GLN   A O   1 
ATOM   446  C CB  . GLN   A 1 70  ? 0.18718   6.54088   37.06715  1.000 27.63988 ? 425  GLN   A CB  1 
ATOM   447  C CG  . GLN   A 1 70  ? -1.20597  7.13442   37.26454  1.000 43.62715 ? 425  GLN   A CG  1 
ATOM   448  C CD  . GLN   A 1 70  ? -2.10286  6.91022   36.03297  1.000 56.34908 ? 425  GLN   A CD  1 
ATOM   449  O OE1 . GLN   A 1 70  ? -1.67125  6.35162   35.01419  1.000 49.53918 ? 425  GLN   A OE1 1 
ATOM   450  N NE2 . GLN   A 1 70  ? -3.35530  7.34201   36.13159  1.000 68.29227 ? 425  GLN   A NE2 1 
ATOM   451  N N   . GLN   A 1 71  ? 0.56077   4.44263   39.65086  1.000 18.86477 ? 426  GLN   A N   1 
ATOM   452  C CA  . GLN   A 1 71  ? -0.10903  3.70403   40.72389  1.000 18.66697 ? 426  GLN   A CA  1 
ATOM   453  C C   . GLN   A 1 71  ? 0.66996   3.69367   42.02098  1.000 26.24554 ? 426  GLN   A C   1 
ATOM   454  O O   . GLN   A 1 71  ? 0.17835   3.16410   43.01940  1.000 23.83756 ? 426  GLN   A O   1 
ATOM   455  C CB  . GLN   A 1 71  ? -0.32737  2.27083   40.27276  1.000 22.43484 ? 426  GLN   A CB  1 
ATOM   456  C CG  . GLN   A 1 71  ? -1.09340  2.18131   38.96676  1.000 24.92673 ? 426  GLN   A CG  1 
ATOM   457  C CD  . GLN   A 1 71  ? -1.28128  0.77021   38.53304  1.000 28.71146 ? 426  GLN   A CD  1 
ATOM   458  O OE1 . GLN   A 1 71  ? -1.99147  0.00694   39.18962  1.000 38.40153 ? 426  GLN   A OE1 1 
ATOM   459  N NE2 . GLN   A 1 71  ? -0.61957  0.38309   37.45268  1.000 26.89705 ? 426  GLN   A NE2 1 
ATOM   460  N N   . LEU   A 1 72  ? 1.87434   4.23340   42.03307  1.000 21.56386 ? 427  LEU   A N   1 
ATOM   461  C CA  . LEU   A 1 72  ? 2.76055   4.14952   43.18093  1.000 20.39653 ? 427  LEU   A CA  1 
ATOM   462  C C   . LEU   A 1 72  ? 2.79738   5.48979   43.89652  1.000 22.81442 ? 427  LEU   A C   1 
ATOM   463  O O   . LEU   A 1 72  ? 2.84315   6.55442   43.26595  1.000 24.94466 ? 427  LEU   A O   1 
ATOM   464  C CB  . LEU   A 1 72  ? 4.17019   3.72064   42.73456  1.000 18.08308 ? 427  LEU   A CB  1 
ATOM   465  C CG  . LEU   A 1 72  ? 4.25045   2.42529   41.94403  1.000 20.71120 ? 427  LEU   A CG  1 
ATOM   466  C CD1 . LEU   A 1 72  ? 5.74932   2.16636   41.58172  1.000 17.70128 ? 427  LEU   A CD1 1 
ATOM   467  C CD2 . LEU   A 1 72  ? 3.64442   1.24270   42.68209  1.000 19.14001 ? 427  LEU   A CD2 1 
ATOM   468  N N   . ASP   A 1 73  ? 2.76583   5.43545   45.21932  1.000 19.06641 ? 428  ASP   A N   1 
ATOM   469  C CA  . ASP   A 1 73  ? 2.67308   6.62316   46.05703  1.000 19.75328 ? 428  ASP   A CA  1 
ATOM   470  C C   . ASP   A 1 73  ? 3.46859   6.32242   47.31478  1.000 22.76017 ? 428  ASP   A C   1 
ATOM   471  O O   . ASP   A 1 73  ? 2.94270   5.74583   48.26280  1.000 23.56572 ? 428  ASP   A O   1 
ATOM   472  C CB  . ASP   A 1 73  ? 1.20432   6.91973   46.35276  1.000 26.28842 ? 428  ASP   A CB  1 
ATOM   473  C CG  . ASP   A 1 73  ? 1.00924   8.05632   47.33722  1.000 42.34440 ? 428  ASP   A CG  1 
ATOM   474  O OD1 . ASP   A 1 73  ? 1.92691   8.89965   47.47624  1.000 28.47760 ? 428  ASP   A OD1 1 
ATOM   475  O OD2 . ASP   A 1 73  ? -0.07983  8.09401   47.98310  1.000 41.74482 ? 428  ASP   A OD2 1 
ATOM   476  N N   . ASN   A 1 74  ? 4.75513   6.69367   47.28914  1.000 18.00686 ? 429  ASN   A N   1 
ATOM   477  C CA  . ASN   A 1 74  ? 5.61075   6.38609   48.42509  1.000 17.27240 ? 429  ASN   A CA  1 
ATOM   478  C C   . ASN   A 1 74  ? 6.78024   7.35364   48.41703  1.000 15.76900 ? 429  ASN   A C   1 
ATOM   479  O O   . ASN   A 1 74  ? 7.26856   7.70639   47.32764  1.000 16.36265 ? 429  ASN   A O   1 
ATOM   480  C CB  . ASN   A 1 74  ? 6.11878   4.94042   48.35004  1.000 17.92756 ? 429  ASN   A CB  1 
ATOM   481  C CG  . ASN   A 1 74  ? 6.98305   4.57950   49.53005  1.000 17.26256 ? 429  ASN   A CG  1 
ATOM   482  O OD1 . ASN   A 1 74  ? 8.19610   4.69008   49.46581  1.000 17.71657 ? 429  ASN   A OD1 1 
ATOM   483  N ND2 . ASN   A 1 74  ? 6.34773   4.21488   50.64825  1.000 20.05497 ? 429  ASN   A ND2 1 
ATOM   484  N N   . PRO   A 1 75  ? 7.29540   7.78461   49.58411  1.000 14.26266 ? 430  PRO   A N   1 
ATOM   485  C CA  . PRO   A 1 75  ? 8.36998   8.77727   49.59635  1.000 13.84631 ? 430  PRO   A CA  1 
ATOM   486  C C   . PRO   A 1 75  ? 9.66729   8.27552   49.00502  1.000 16.31182 ? 430  PRO   A C   1 
ATOM   487  O O   . PRO   A 1 75  ? 10.47695  9.10168   48.59619  1.000 17.24202 ? 430  PRO   A O   1 
ATOM   488  C CB  . PRO   A 1 75  ? 8.57013   9.11327   51.08150  1.000 20.81335 ? 430  PRO   A CB  1 
ATOM   489  C CG  . PRO   A 1 75  ? 7.30716   8.64608   51.73353  1.000 23.30806 ? 430  PRO   A CG  1 
ATOM   490  C CD  . PRO   A 1 75  ? 6.77362   7.49021   50.93882  1.000 17.25889 ? 430  PRO   A CD  1 
ATOM   491  N N   . TYR   A 1 76  ? 9.83491   6.96501   48.89292  1.000 15.19400 ? 431  TYR   A N   1 
ATOM   492  C CA  . TYR   A 1 76  ? 11.12047  6.41791   48.44227  1.000 13.57881 ? 431  TYR   A CA  1 
ATOM   493  C C   . TYR   A 1 76  ? 11.03311  5.88164   47.02432  1.000 15.09754 ? 431  TYR   A C   1 
ATOM   494  O O   . TYR   A 1 76  ? 11.83750  5.04902   46.63378  1.000 13.08526 ? 431  TYR   A O   1 
ATOM   495  C CB  . TYR   A 1 76  ? 11.59243  5.34953   49.42990  1.000 14.36245 ? 431  TYR   A CB  1 
ATOM   496  C CG  . TYR   A 1 76  ? 11.66398  5.96691   50.81457  1.000 14.39071 ? 431  TYR   A CG  1 
ATOM   497  C CD1 . TYR   A 1 76  ? 12.61481  6.94647   51.07914  1.000 12.33890 ? 431  TYR   A CD1 1 
ATOM   498  C CD2 . TYR   A 1 76  ? 10.72687  5.63550   51.77331  1.000 16.45187 ? 431  TYR   A CD2 1 
ATOM   499  C CE1 . TYR   A 1 76  ? 12.69150  7.56652   52.36061  1.000 15.75639 ? 431  TYR   A CE1 1 
ATOM   500  C CE2 . TYR   A 1 76  ? 10.77970  6.23349   53.01700  1.000 16.54248 ? 431  TYR   A CE2 1 
ATOM   501  C CZ  . TYR   A 1 76  ? 11.75175  7.17351   53.27174  1.000 15.36594 ? 431  TYR   A CZ  1 
ATOM   502  O OH  . TYR   A 1 76  ? 11.84007  7.79768   54.54545  1.000 24.12736 ? 431  TYR   A OH  1 
ATOM   503  N N   . ILE   A 1 77  ? 10.02136  6.33127   46.27398  1.000 14.57089 ? 432  ILE   A N   1 
ATOM   504  C CA  . ILE   A 1 77  ? 9.85249   5.99231   44.87482  1.000 13.73660 ? 432  ILE   A CA  1 
ATOM   505  C C   . ILE   A 1 77  ? 9.72107   7.28389   44.08020  1.000 14.92693 ? 432  ILE   A C   1 
ATOM   506  O O   . ILE   A 1 77  ? 8.99796   8.20474   44.47838  1.000 16.71210 ? 432  ILE   A O   1 
ATOM   507  C CB  . ILE   A 1 77  ? 8.62964   5.10864   44.65181  1.000 14.45844 ? 432  ILE   A CB  1 
ATOM   508  C CG1 . ILE   A 1 77  ? 8.78940   3.82836   45.47924  1.000 19.37715 ? 432  ILE   A CG1 1 
ATOM   509  C CG2 . ILE   A 1 77  ? 8.45389   4.77838   43.19515  1.000 17.21014 ? 432  ILE   A CG2 1 
ATOM   510  C CD1 . ILE   A 1 77  ? 7.77854   2.74117   45.20937  1.000 20.84477 ? 432  ILE   A CD1 1 
ATOM   511  N N   . VAL   A 1 78  ? 10.39724  7.33833   42.92384  1.000 13.82523 ? 433  VAL   A N   1 
ATOM   512  C CA  . VAL   A 1 78  ? 10.28268  8.54902   42.09184  1.000 12.97927 ? 433  VAL   A CA  1 
ATOM   513  C C   . VAL   A 1 78  ? 8.83249   8.78583   41.65388  1.000 14.41416 ? 433  VAL   A C   1 
ATOM   514  O O   . VAL   A 1 78  ? 8.18151   7.86349   41.18147  1.000 15.94773 ? 433  VAL   A O   1 
ATOM   515  C CB  . VAL   A 1 78  ? 11.19014  8.41862   40.85608  1.000 13.65455 ? 433  VAL   A CB  1 
ATOM   516  C CG1 . VAL   A 1 78  ? 10.90291  9.56699   39.83386  1.000 14.23752 ? 433  VAL   A CG1 1 
ATOM   517  C CG2 . VAL   A 1 78  ? 12.67410  8.44526   41.28871  1.000 17.45866 ? 433  VAL   A CG2 1 
ATOM   518  N N   . ARG   A 1 79  ? 8.35238   10.02726  41.77354  1.000 16.46132 ? 434  ARG   A N   1 
ATOM   519  C CA  . ARG   A 1 79  ? 6.98487   10.39950  41.40528  1.000 14.79915 ? 434  ARG   A CA  1 
ATOM   520  C C   . ARG   A 1 79  ? 6.95131   10.80697  39.93034  1.000 15.87327 ? 434  ARG   A C   1 
ATOM   521  O O   . ARG   A 1 79  ? 7.74929   11.62336  39.47725  1.000 18.68633 ? 434  ARG   A O   1 
ATOM   522  C CB  . ARG   A 1 79  ? 6.50323   11.53023  42.30624  1.000 18.37517 ? 434  ARG   A CB  1 
ATOM   523  C CG  . ARG   A 1 79  ? 6.31089   11.02977  43.72060  1.000 27.56748 ? 434  ARG   A CG  1 
ATOM   524  C CD  . ARG   A 1 79  ? 5.52769   11.94711  44.60836  1.000 28.50056 ? 434  ARG   A CD  1 
ATOM   525  N NE  . ARG   A 1 79  ? 5.69926   11.53108  46.00399  1.000 30.48044 ? 434  ARG   A NE  1 
ATOM   526  C CZ  . ARG   A 1 79  ? 4.95701   10.62297  46.63400  1.000 35.07740 ? 434  ARG   A CZ  1 
ATOM   527  N NH1 . ARG   A 1 79  ? 4.02346   9.92545   46.00145  1.000 30.08301 ? 434  ARG   A NH1 1 
ATOM   528  N NH2 . ARG   A 1 79  ? 5.14359   10.42007  47.94064  1.000 28.32449 ? 434  ARG   A NH2 1 
ATOM   529  N N   . MET   A 1 80  ? 6.00864   10.25900  39.20008  1.000 15.11125 ? 435  MET   A N   1 
ATOM   530  C CA  . MET   A 1 80  ? 5.76581   10.69219  37.82709  1.000 16.38917 ? 435  MET   A CA  1 
ATOM   531  C C   . MET   A 1 80  ? 4.81605   11.89516  37.83370  1.000 17.29525 ? 435  MET   A C   1 
ATOM   532  O O   . MET   A 1 80  ? 3.86281   11.92506  38.62018  1.000 19.11570 ? 435  MET   A O   1 
ATOM   533  C CB  . MET   A 1 80  ? 5.15910   9.53350   37.03631  1.000 21.03049 ? 435  MET   A CB  1 
ATOM   534  C CG  . MET   A 1 80  ? 5.03016   9.80839   35.56234  1.000 29.91362 ? 435  MET   A CG  1 
ATOM   535  S SD  . MET   A 1 80  ? 3.60047   8.89585   34.96671  1.000 37.80354 ? 435  MET   A SD  1 
ATOM   536  C CE  . MET   A 1 80  ? 2.54149   9.85202   36.18496  1.000 15.70491 ? 435  MET   A CE  1 
ATOM   537  N N   . ILE   A 1 81  ? 5.10614   12.89845  37.00693  1.000 15.03566 ? 436  ILE   A N   1 
ATOM   538  C CA  . ILE   A 1 81  ? 4.13386   13.98023  36.79014  1.000 14.41589 ? 436  ILE   A CA  1 
ATOM   539  C C   . ILE   A 1 81  ? 3.15770   13.63033  35.66761  1.000 17.69914 ? 436  ILE   A C   1 
ATOM   540  O O   . ILE   A 1 81  ? 1.94484   13.83947  35.81242  1.000 19.67307 ? 436  ILE   A O   1 
ATOM   541  C CB  . ILE   A 1 81  ? 4.87233   15.29039  36.49453  1.000 17.26601 ? 436  ILE   A CB  1 
ATOM   542  C CG1 . ILE   A 1 81  ? 6.03521   15.61902  37.47388  1.000 21.24262 ? 436  ILE   A CG1 1 
ATOM   543  C CG2 . ILE   A 1 81  ? 3.85863   16.43860  36.41630  1.000 19.25252 ? 436  ILE   A CG2 1 
ATOM   544  C CD1 . ILE   A 1 81  ? 5.59608   15.81112  38.85385  1.000 24.16190 ? 436  ILE   A CD1 1 
ATOM   545  N N   . GLY   A 1 82  ? 3.66661   13.13761  34.54029  1.000 16.62818 ? 437  GLY   A N   1 
ATOM   546  C CA  . GLY   A 1 82  ? 2.78254   12.60832  33.51979  1.000 16.05266 ? 437  GLY   A CA  1 
ATOM   547  C C   . GLY   A 1 82  ? 3.57620   12.26227  32.28496  1.000 15.06785 ? 437  GLY   A C   1 
ATOM   548  O O   . GLY   A 1 82  ? 4.79807   12.23989  32.29483  1.000 17.60296 ? 437  GLY   A O   1 
ATOM   549  N N   . ILE   A 1 83  ? 2.84844   11.98240  31.20841  1.000 18.42177 ? 438  ILE   A N   1 
ATOM   550  C CA  . ILE   A 1 83  ? 3.44313   11.77590  29.91041  1.000 15.99215 ? 438  ILE   A CA  1 
ATOM   551  C C   . ILE   A 1 83  ? 3.05712   12.92471  29.00172  1.000 19.54737 ? 438  ILE   A C   1 
ATOM   552  O O   . ILE   A 1 83  ? 2.02185   13.56833  29.18554  1.000 22.14683 ? 438  ILE   A O   1 
ATOM   553  C CB  . ILE   A 1 83  ? 3.01842   10.45357  29.25692  1.000 19.29578 ? 438  ILE   A CB  1 
ATOM   554  C CG1 . ILE   A 1 83  ? 1.52133   10.25658  29.38808  1.000 27.41422 ? 438  ILE   A CG1 1 
ATOM   555  C CG2 . ILE   A 1 83  ? 3.69975   9.31229   29.95665  1.000 24.59736 ? 438  ILE   A CG2 1 
ATOM   556  C CD1 . ILE   A 1 83  ? 1.07062   8.87836   28.87663  1.000 41.29237 ? 438  ILE   A CD1 1 
ATOM   557  N N   . CYS   A 1 84  ? 3.91410   13.17700  28.02110  1.000 21.39739 ? 439  CYS   A N   1 
ATOM   558  C CA  . CYS   A 1 84  ? 3.68915   14.25184  27.06463  1.000 20.11214 ? 439  CYS   A CA  1 
ATOM   559  C C   . CYS   A 1 84  ? 4.02787   13.69319  25.69621  1.000 20.30234 ? 439  CYS   A C   1 
ATOM   560  O O   . CYS   A 1 84  ? 5.11878   13.17870  25.49836  1.000 20.40074 ? 439  CYS   A O   1 
ATOM   561  C CB  . CYS   A 1 84  ? 4.56618   15.47331  27.40287  1.000 21.52911 ? 439  CYS   A CB  1 
ATOM   562  S SG  . CYS   A 1 84  ? 4.19929   16.98222  26.46612  1.000 30.70188 ? 439  CYS   A SG  1 
ATOM   563  N N   . GLU   A 1 85  ? 3.11980   13.84370  24.74671  1.000 20.83677 ? 440  GLU   A N   1 
ATOM   564  C CA  . GLU   A 1 85  ? 3.29226   13.34539  23.39571  1.000 23.69029 ? 440  GLU   A CA  1 
ATOM   565  C C   . GLU   A 1 85  ? 3.53292   14.56978  22.53914  1.000 24.16917 ? 440  GLU   A C   1 
ATOM   566  O O   . GLU   A 1 85  ? 2.60534   15.33286  22.24146  1.000 32.21246 ? 440  GLU   A O   1 
ATOM   567  C CB  . GLU   A 1 85  ? 2.06537   12.56012  22.95904  1.000 33.15485 ? 440  GLU   A CB  1 
ATOM   568  C CG  . GLU   A 1 85  ? 2.17607   11.94157  21.58877  1.000 43.31816 ? 440  GLU   A CG  1 
ATOM   569  C CD  . GLU   A 1 85  ? 0.85869   11.31594  21.14574  1.000 45.69242 ? 440  GLU   A CD  1 
ATOM   570  O OE1 . GLU   A 1 85  ? -0.05918  11.16895  21.99799  1.000 45.02338 ? 440  GLU   A OE1 1 
ATOM   571  O OE2 . GLU   A 1 85  ? 0.74660   10.97511  19.95127  1.000 48.14316 ? 440  GLU   A OE2 1 
ATOM   572  N N   . ALA   A 1 86  ? 4.78199   14.79949  22.21099  1.000 22.46921 ? 441  ALA   A N   1 
ATOM   573  C CA  . ALA   A 1 86  ? 5.07914   15.97159  21.40609  1.000 27.64789 ? 441  ALA   A CA  1 
ATOM   574  C C   . ALA   A 1 86  ? 6.10876   15.60779  20.35900  1.000 26.05282 ? 441  ALA   A C   1 
ATOM   575  O O   . ALA   A 1 86  ? 5.95459   14.60743  19.63593  1.000 29.68133 ? 441  ALA   A O   1 
ATOM   576  C CB  . ALA   A 1 86  ? 5.56277   17.12090  22.29382  1.000 29.21333 ? 441  ALA   A CB  1 
ATOM   577  N N   . GLU   A 1 87  ? 7.16688   16.40141  20.27195  1.000 32.31749 ? 442  GLU   A N   1 
ATOM   578  C CA  . GLU   A 1 87  ? 8.15688   16.14392  19.24139  1.000 31.80079 ? 442  GLU   A CA  1 
ATOM   579  C C   . GLU   A 1 87  ? 8.68089   14.71774  19.35230  1.000 35.36256 ? 442  GLU   A C   1 
ATOM   580  O O   . GLU   A 1 87  ? 8.84820   14.03987  18.33923  1.000 36.71718 ? 442  GLU   A O   1 
ATOM   581  C CB  . GLU   A 1 87  ? 9.26752   17.19804  19.30733  1.000 32.18443 ? 442  GLU   A CB  1 
ATOM   582  C CG  . GLU   A 1 87  ? 10.09570  17.22212  20.60390  1.000 45.96131 ? 442  GLU   A CG  1 
ATOM   583  C CD  . GLU   A 1 87  ? 9.62640   18.26758  21.61506  1.000 45.50903 ? 442  GLU   A CD  1 
ATOM   584  O OE1 . GLU   A 1 87  ? 8.41002   18.54285  21.67041  1.000 31.91375 ? 442  GLU   A OE1 1 
ATOM   585  O OE2 . GLU   A 1 87  ? 10.48188  18.81280  22.35408  1.000 44.29316 ? 442  GLU   A OE2 1 
ATOM   586  N N   . SER   A 1 88  ? 8.84904   14.20744  20.57670  1.000 32.50178 ? 443  SER   A N   1 
ATOM   587  C CA  . SER   A 1 88  ? 8.97367   12.77328  20.84104  1.000 28.02598 ? 443  SER   A CA  1 
ATOM   588  C C   . SER   A 1 88  ? 8.06565   12.43931  22.02325  1.000 21.23206 ? 443  SER   A C   1 
ATOM   589  O O   . SER   A 1 88  ? 7.47363   13.33173  22.62423  1.000 23.96268 ? 443  SER   A O   1 
ATOM   590  C CB  . SER   A 1 88  ? 10.42202  12.36196  21.15302  1.000 37.08517 ? 443  SER   A CB  1 
ATOM   591  O OG  . SER   A 1 88  ? 11.37618  13.08841  20.38164  1.000 48.93174 ? 443  SER   A OG  1 
ATOM   592  N N   . TRP   A 1 89  ? 7.96192   11.15132  22.36125  1.000 22.10292 ? 444  TRP   A N   1 
ATOM   593  C CA  . TRP   A 1 89  ? 7.26900   10.70345  23.57872  1.000 24.73784 ? 444  TRP   A CA  1 
ATOM   594  C C   . TRP   A 1 89  ? 8.12048   10.94694  24.81437  1.000 19.61621 ? 444  TRP   A C   1 
ATOM   595  O O   . TRP   A 1 89  ? 9.32252   10.70589  24.80355  1.000 20.61161 ? 444  TRP   A O   1 
ATOM   596  C CB  . TRP   A 1 89  ? 6.96452   9.21525   23.52608  1.000 31.05407 ? 444  TRP   A CB  1 
ATOM   597  C CG  . TRP   A 1 89  ? 5.83139   8.86971   22.67581  1.000 33.55105 ? 444  TRP   A CG  1 
ATOM   598  C CD1 . TRP   A 1 89  ? 5.88837   8.38575   21.40002  1.000 35.88556 ? 444  TRP   A CD1 1 
ATOM   599  C CD2 . TRP   A 1 89  ? 4.44990   8.92701   23.03077  1.000 26.01858 ? 444  TRP   A CD2 1 
ATOM   600  N NE1 . TRP   A 1 89  ? 4.61974   8.14964   20.94069  1.000 33.19193 ? 444  TRP   A NE1 1 
ATOM   601  C CE2 . TRP   A 1 89  ? 3.71875   8.47122   21.91936  1.000 31.64867 ? 444  TRP   A CE2 1 
ATOM   602  C CE3 . TRP   A 1 89  ? 3.75315   9.32806   24.17155  1.000 31.35791 ? 444  TRP   A CE3 1 
ATOM   603  C CZ2 . TRP   A 1 89  ? 2.33161   8.42345   21.91391  1.000 37.95780 ? 444  TRP   A CZ2 1 
ATOM   604  C CZ3 . TRP   A 1 89  ? 2.37386   9.26238   24.17016  1.000 40.30773 ? 444  TRP   A CZ3 1 
ATOM   605  C CH2 . TRP   A 1 89  ? 1.67700   8.81514   23.04813  1.000 39.24663 ? 444  TRP   A CH2 1 
ATOM   606  N N   . MET   A 1 90  ? 7.49095   11.46840  25.87442  1.000 17.63407 ? 445  MET   A N   1 
ATOM   607  C CA  . MET   A 1 90  ? 8.22192   11.93185  27.05326  1.000 16.11650 ? 445  MET   A CA  1 
ATOM   608  C C   . MET   A 1 90  ? 7.54048   11.47266  28.33071  1.000 16.00239 ? 445  MET   A C   1 
ATOM   609  O O   . MET   A 1 90  ? 6.33723   11.63934  28.49930  1.000 18.18732 ? 445  MET   A O   1 
ATOM   610  C CB  . MET   A 1 90  ? 8.31367   13.46015  27.07621  1.000 19.05528 ? 445  MET   A CB  1 
ATOM   611  C CG  . MET   A 1 90  ? 8.94409   14.01255  25.81651  1.000 17.28825 ? 445  MET   A CG  1 
ATOM   612  S SD  . MET   A 1 90  ? 9.02097   15.81023  25.93659  1.000 25.42095 ? 445  MET   A SD  1 
ATOM   613  C CE  . MET   A 1 90  ? 7.42318   16.14679  25.25007  1.000 33.93874 ? 445  MET   A CE  1 
ATOM   614  N N   . LEU   A 1 91  ? 8.34902   10.99753  29.27266  1.000 16.24309 ? 446  LEU   A N   1 
ATOM   615  C CA  . LEU   A 1 91  ? 7.89846   10.65952  30.61236  1.000 14.01426 ? 446  LEU   A CA  1 
ATOM   616  C C   . LEU   A 1 91  ? 8.52399   11.70596  31.52995  1.000 11.57374 ? 446  LEU   A C   1 
ATOM   617  O O   . LEU   A 1 91  ? 9.75243   11.79317  31.61976  1.000 12.66801 ? 446  LEU   A O   1 
ATOM   618  C CB  . LEU   A 1 91  ? 8.34153   9.22337   30.97062  1.000 15.31140 ? 446  LEU   A CB  1 
ATOM   619  C CG  . LEU   A 1 91  ? 8.16841   8.78939   32.43732  1.000 15.31688 ? 446  LEU   A CG  1 
ATOM   620  C CD1 . LEU   A 1 91  ? 6.67708   8.82163   32.76317  1.000 21.56401 ? 446  LEU   A CD1 1 
ATOM   621  C CD2 . LEU   A 1 91  ? 8.78907   7.39591   32.66692  1.000 17.03416 ? 446  LEU   A CD2 1 
ATOM   622  N N   . VAL   A 1 92  ? 7.66359   12.51279  32.15410  1.000 13.34416 ? 447  VAL   A N   1 
ATOM   623  C CA  . VAL   A 1 92  ? 8.07032   13.65153  32.99715  1.000 14.03936 ? 447  VAL   A CA  1 
ATOM   624  C C   . VAL   A 1 92  ? 7.96438   13.22388  34.45825  1.000 13.43092 ? 447  VAL   A C   1 
ATOM   625  O O   . VAL   A 1 92  ? 6.90571   12.76627  34.89910  1.000 13.79562 ? 447  VAL   A O   1 
ATOM   626  C CB  . VAL   A 1 92  ? 7.16993   14.86589  32.70646  1.000 13.29752 ? 447  VAL   A CB  1 
ATOM   627  C CG1 . VAL   A 1 92  ? 7.56205   16.03585  33.63556  1.000 14.86829 ? 447  VAL   A CG1 1 
ATOM   628  C CG2 . VAL   A 1 92  ? 7.24446   15.28346  31.22881  1.000 16.45601 ? 447  VAL   A CG2 1 
ATOM   629  N N   . MET   A 1 93  ? 9.06991   13.34315  35.19700  1.000 12.85313 ? 448  MET   A N   1 
ATOM   630  C CA  . MET   A 1 93  ? 9.16767   12.87891  36.58138  1.000 12.35919 ? 448  MET   A CA  1 
ATOM   631  C C   . MET   A 1 93  ? 9.68523   14.00967  37.47126  1.000 11.19119 ? 448  MET   A C   1 
ATOM   632  O O   . MET   A 1 93  ? 10.35972  14.89920  36.99985  1.000 13.09128 ? 448  MET   A O   1 
ATOM   633  C CB  . MET   A 1 93  ? 10.13295  11.67964  36.68604  1.000 12.77965 ? 448  MET   A CB  1 
ATOM   634  C CG  . MET   A 1 93  ? 9.55869   10.46376  35.94230  1.000 13.00510 ? 448  MET   A CG  1 
ATOM   635  S SD  . MET   A 1 93  ? 10.84317  9.27268   35.57569  1.000 15.39831 ? 448  MET   A SD  1 
ATOM   636  C CE  . MET   A 1 93  ? 11.73625  10.12416  34.24427  1.000 17.52430 ? 448  MET   A CE  1 
ATOM   637  N N   . GLU   A 1 94  ? 9.37311   13.94253  38.77602  1.000 12.98533 ? 449  GLU   A N   1 
ATOM   638  C CA  . GLU   A 1 94  ? 10.04498  14.82841  39.73595  1.000 14.03189 ? 449  GLU   A CA  1 
ATOM   639  C C   . GLU   A 1 94  ? 11.55984  14.64131  39.65331  1.000 12.94949 ? 449  GLU   A C   1 
ATOM   640  O O   . GLU   A 1 94  ? 12.01556  13.50917  39.54538  1.000 16.02597 ? 449  GLU   A O   1 
ATOM   641  C CB  . GLU   A 1 94  ? 9.60759   14.47286  41.16037  1.000 16.40125 ? 449  GLU   A CB  1 
ATOM   642  C CG  . GLU   A 1 94  ? 8.17917   14.80011  41.49202  1.000 28.20282 ? 449  GLU   A CG  1 
ATOM   643  C CD  . GLU   A 1 94  ? 7.92655   14.76551  43.00026  1.000 35.14369 ? 449  GLU   A CD  1 
ATOM   644  O OE1 . GLU   A 1 94  ? 8.64836   14.02252  43.71057  1.000 34.72053 ? 449  GLU   A OE1 1 
ATOM   645  O OE2 . GLU   A 1 94  ? 7.01693   15.49052  43.45469  1.000 32.80627 ? 449  GLU   A OE2 1 
ATOM   646  N N   . MET   A 1 95  ? 12.34485  15.73184  39.67502  1.000 14.14211 ? 450  MET   A N   1 
ATOM   647  C CA  . MET   A 1 95  ? 13.81280  15.63729  39.54535  1.000 13.70183 ? 450  MET   A CA  1 
ATOM   648  C C   . MET   A 1 95  ? 14.46732  15.22729  40.86566  1.000 15.25692 ? 450  MET   A C   1 
ATOM   649  O O   . MET   A 1 95  ? 14.24873  15.88897  41.89535  1.000 15.81280 ? 450  MET   A O   1 
ATOM   650  C CB  . MET   A 1 95  ? 14.36370  16.98974  39.09709  1.000 13.08344 ? 450  MET   A CB  1 
ATOM   651  C CG  . MET   A 1 95  ? 15.87311  17.11622  39.24450  1.000 16.28798 ? 450  MET   A CG  1 
ATOM   652  S SD  . MET   A 1 95  ? 16.75050  16.03264  38.10126  1.000 16.19157 ? 450  MET   A SD  1 
ATOM   653  C CE  . MET   A 1 95  ? 16.61570  16.90200  36.51998  1.000 17.89674 ? 450  MET   A CE  1 
ATOM   654  N N   . ALA   A 1 96  ? 15.27461  14.17358  40.81462  1.000 15.14237 ? 451  ALA   A N   1 
ATOM   655  C CA  . ALA   A 1 96  ? 16.20698  13.81827  41.89125  1.000 13.10860 ? 451  ALA   A CA  1 
ATOM   656  C C   . ALA   A 1 96  ? 17.56634  14.39664  41.47748  1.000 12.30909 ? 451  ALA   A C   1 
ATOM   657  O O   . ALA   A 1 96  ? 18.24396  13.87249  40.59033  1.000 13.85130 ? 451  ALA   A O   1 
ATOM   658  C CB  . ALA   A 1 96  ? 16.23691  12.30312  42.07292  1.000 14.71789 ? 451  ALA   A CB  1 
ATOM   659  N N   . GLU   A 1 97  ? 17.95866  15.52316  42.10568  1.000 14.34640 ? 452  GLU   A N   1 
ATOM   660  C CA  . GLU   A 1 97  ? 19.01562  16.35016  41.56043  1.000 13.88282 ? 452  GLU   A CA  1 
ATOM   661  C C   . GLU   A 1 97  ? 20.39774  15.72046  41.61527  1.000 13.29986 ? 452  GLU   A C   1 
ATOM   662  O O   . GLU   A 1 97  ? 21.26263  16.12150  40.84208  1.000 14.92305 ? 452  GLU   A O   1 
ATOM   663  C CB  . GLU   A 1 97  ? 19.08096  17.68076  42.34580  1.000 15.16500 ? 452  GLU   A CB  1 
ATOM   664  C CG  . GLU   A 1 97  ? 17.87424  18.54228  42.15721  1.000 14.56166 ? 452  GLU   A CG  1 
ATOM   665  C CD  . GLU   A 1 97  ? 17.91577  19.34837  40.89703  1.000 15.09589 ? 452  GLU   A CD  1 
ATOM   666  O OE1 . GLU   A 1 97  ? 18.84604  19.22517  40.07431  1.000 19.79067 ? 452  GLU   A OE1 1 
ATOM   667  O OE2 . GLU   A 1 97  ? 16.95833  20.17904  40.67359  1.000 17.89926 ? 452  GLU   A OE2 1 
ATOM   668  N N   . LEU   A 1 98  ? 20.64219  14.75680  42.50687  1.000 13.33261 ? 453  LEU   A N   1 
ATOM   669  C CA  . LEU   A 1 98  ? 22.00825  14.25033  42.59457  1.000 15.81506 ? 453  LEU   A CA  1 
ATOM   670  C C   . LEU   A 1 98  ? 22.24896  13.04277  41.71993  1.000 16.09103 ? 453  LEU   A C   1 
ATOM   671  O O   . LEU   A 1 98  ? 23.40640  12.61407  41.59702  1.000 15.87032 ? 453  LEU   A O   1 
ATOM   672  C CB  . LEU   A 1 98  ? 22.37807  13.90896  44.04841  1.000 15.55471 ? 453  LEU   A CB  1 
ATOM   673  C CG  . LEU   A 1 98  ? 22.78914  15.09536  44.95950  1.000 16.88188 ? 453  LEU   A CG  1 
ATOM   674  C CD1 . LEU   A 1 98  ? 21.77667  16.21821  44.96133  1.000 17.23071 ? 453  LEU   A CD1 1 
ATOM   675  C CD2 . LEU   A 1 98  ? 23.04052  14.54658  46.33383  1.000 17.20129 ? 453  LEU   A CD2 1 
ATOM   676  N N   . GLY   A 1 99  ? 21.20732  12.51174  41.07616  1.000 14.69219 ? 454  GLY   A N   1 
ATOM   677  C CA  . GLY   A 1 99  ? 21.41491  11.53768  40.02493  1.000 14.53915 ? 454  GLY   A CA  1 
ATOM   678  C C   . GLY   A 1 99  ? 21.58587  10.13417  40.59706  1.000 11.56291 ? 454  GLY   A C   1 
ATOM   679  O O   . GLY   A 1 99  ? 21.36918  9.85627   41.78419  1.000 13.25424 ? 454  GLY   A O   1 
ATOM   680  N N   . PRO   A 1 100 ? 22.01053  9.22687   39.73885  1.000 12.18436 ? 455  PRO   A N   1 
ATOM   681  C CA  . PRO   A 1 100 ? 22.15143  7.80499   40.12441  1.000 13.53980 ? 455  PRO   A CA  1 
ATOM   682  C C   . PRO   A 1 100 ? 23.14695  7.56435   41.24710  1.000 12.51634 ? 455  PRO   A C   1 
ATOM   683  O O   . PRO   A 1 100 ? 24.24417  8.15975   41.31347  1.000 13.91545 ? 455  PRO   A O   1 
ATOM   684  C CB  . PRO   A 1 100 ? 22.62007  7.13442   38.82983  1.000 14.44691 ? 455  PRO   A CB  1 
ATOM   685  C CG  . PRO   A 1 100 ? 21.97979  7.98528   37.73385  1.000 14.77611 ? 455  PRO   A CG  1 
ATOM   686  C CD  . PRO   A 1 100 ? 22.11310  9.42526   38.26399  1.000 14.00549 ? 455  PRO   A CD  1 
ATOM   687  N N   . LEU   A 1 101 ? 22.74414  6.66862   42.14709  1.000 12.21374 ? 456  LEU   A N   1 
ATOM   688  C CA  . LEU   A 1 101 ? 23.51736  6.33529   43.34300  1.000 10.85480 ? 456  LEU   A CA  1 
ATOM   689  C C   . LEU   A 1 101 ? 24.89920  5.79005   43.02118  1.000 12.75113 ? 456  LEU   A C   1 
ATOM   690  O O   . LEU   A 1 101 ? 25.86943  6.15334   43.70627  1.000 14.64326 ? 456  LEU   A O   1 
ATOM   691  C CB  . LEU   A 1 101 ? 22.72744  5.33041   44.18207  1.000 12.75117 ? 456  LEU   A CB  1 
ATOM   692  C CG  . LEU   A 1 101 ? 23.46120  4.82115   45.43050  1.000 12.57212 ? 456  LEU   A CG  1 
ATOM   693  C CD1 . LEU   A 1 101 ? 23.72115  5.93201   46.49750  1.000 14.71289 ? 456  LEU   A CD1 1 
ATOM   694  C CD2 . LEU   A 1 101 ? 22.69502  3.63180   46.05585  1.000 15.66990 ? 456  LEU   A CD2 1 
ATOM   695  N N   . ASN   A 1 102 ? 25.01472  4.88192   42.04194  1.000 12.24662 ? 457  ASN   A N   1 
ATOM   696  C CA  . ASN   A 1 102 ? 26.33830  4.31416   41.79832  1.000 14.01404 ? 457  ASN   A CA  1 
ATOM   697  C C   . ASN   A 1 102 ? 27.33864  5.38702   41.36947  1.000 14.73399 ? 457  ASN   A C   1 
ATOM   698  O O   . ASN   A 1 102 ? 28.44951  5.44116   41.91068  1.000 16.10171 ? 457  ASN   A O   1 
ATOM   699  C CB  . ASN   A 1 102 ? 26.28282  3.16950   40.75824  1.000 16.14790 ? 457  ASN   A CB  1 
ATOM   700  C CG  . ASN   A 1 102 ? 25.75878  3.58690   39.39501  1.000 16.91237 ? 457  ASN   A CG  1 
ATOM   701  O OD1 . ASN   A 1 102 ? 24.96875  4.52101   39.21900  1.000 16.40193 ? 457  ASN   A OD1 1 
ATOM   702  N ND2 . ASN   A 1 102 ? 26.17444  2.80991   38.36428  1.000 21.69863 ? 457  ASN   A ND2 1 
ATOM   703  N N   . LYS   A 1 103 ? 26.93699  6.26423   40.45539  1.000 15.07763 ? 458  LYS   A N   1 
ATOM   704  C CA  . LYS   A 1 103 ? 27.79971  7.35354   40.00908  1.000 15.59109 ? 458  LYS   A CA  1 
ATOM   705  C C   . LYS   A 1 103 ? 28.10525  8.32113   41.14223  1.000 16.53572 ? 458  LYS   A C   1 
ATOM   706  O O   . LYS   A 1 103 ? 29.24812  8.76300   41.29806  1.000 16.80091 ? 458  LYS   A O   1 
ATOM   707  C CB  . LYS   A 1 103 ? 27.12994  8.04752   38.82022  1.000 18.62337 ? 458  LYS   A CB  1 
ATOM   708  C CG  . LYS   A 1 103 ? 27.93315  9.23674   38.28510  1.000 26.57092 ? 458  LYS   A CG  1 
ATOM   709  C CD  . LYS   A 1 103 ? 29.32988  8.83486   37.94495  1.000 31.65210 ? 458  LYS   A CD  1 
ATOM   710  C CE  . LYS   A 1 103 ? 30.09791  10.02632  37.39843  1.000 44.16206 ? 458  LYS   A CE  1 
ATOM   711  N NZ  . LYS   A 1 103 ? 29.80494  10.19614  35.94886  1.000 47.31802 ? 458  LYS   A NZ  1 
ATOM   712  N N   . TYR   A 1 104 ? 27.10048  8.65591   41.95765  1.000 15.16923 ? 459  TYR   A N   1 
ATOM   713  C CA  . TYR   A 1 104 ? 27.36155  9.55634   43.06977  1.000 15.98776 ? 459  TYR   A CA  1 
ATOM   714  C C   . TYR   A 1 104 ? 28.41121  8.98617   44.01387  1.000 17.51717 ? 459  TYR   A C   1 
ATOM   715  O O   . TYR   A 1 104 ? 29.30209  9.69931   44.47086  1.000 16.69710 ? 459  TYR   A O   1 
ATOM   716  C CB  . TYR   A 1 104 ? 26.06625  9.83042   43.84618  1.000 15.36250 ? 459  TYR   A CB  1 
ATOM   717  C CG  . TYR   A 1 104 ? 26.25164  10.85812  44.94046  1.000 13.87733 ? 459  TYR   A CG  1 
ATOM   718  C CD1 . TYR   A 1 104 ? 26.12276  12.20524  44.63485  1.000 15.49402 ? 459  TYR   A CD1 1 
ATOM   719  C CD2 . TYR   A 1 104 ? 26.59072  10.49236  46.24406  1.000 16.01787 ? 459  TYR   A CD2 1 
ATOM   720  C CE1 . TYR   A 1 104 ? 26.31215  13.18940  45.62433  1.000 18.66202 ? 459  TYR   A CE1 1 
ATOM   721  C CE2 . TYR   A 1 104 ? 26.79362  11.48715  47.23740  1.000 18.22725 ? 459  TYR   A CE2 1 
ATOM   722  C CZ  . TYR   A 1 104 ? 26.62984  12.79693  46.89045  1.000 20.83287 ? 459  TYR   A CZ  1 
ATOM   723  O OH  . TYR   A 1 104 ? 26.81485  13.75995  47.85144  1.000 23.77667 ? 459  TYR   A OH  1 
ATOM   724  N N   . LEU   A 1 105 ? 28.32109  7.69852   44.32798  1.000 12.67586 ? 460  LEU   A N   1 
ATOM   725  C CA  . LEU   A 1 105 ? 29.27655  7.11761   45.26790  1.000 13.40337 ? 460  LEU   A CA  1 
ATOM   726  C C   . LEU   A 1 105 ? 30.65764  6.99161   44.62715  1.000 15.39221 ? 460  LEU   A C   1 
ATOM   727  O O   . LEU   A 1 105 ? 31.65805  7.14179   45.32470  1.000 17.60775 ? 460  LEU   A O   1 
ATOM   728  C CB  . LEU   A 1 105 ? 28.74493  5.77042   45.78688  1.000 16.42731 ? 460  LEU   A CB  1 
ATOM   729  C CG  . LEU   A 1 105 ? 27.50916  5.84809   46.70487  1.000 15.01784 ? 460  LEU   A CG  1 
ATOM   730  C CD1 . LEU   A 1 105 ? 27.02979  4.44593   47.05694  1.000 17.15177 ? 460  LEU   A CD1 1 
ATOM   731  C CD2 . LEU   A 1 105 ? 27.81133  6.61263   47.96746  1.000 21.43678 ? 460  LEU   A CD2 1 
ATOM   732  N N   . GLN   A 1 106 ? 30.71318  6.73706   43.32367  1.000 15.50626 ? 461  GLN   A N   1 
ATOM   733  C CA  . GLN   A 1 106 ? 32.01451  6.72605   42.64043  1.000 16.23209 ? 461  GLN   A CA  1 
ATOM   734  C C   . GLN   A 1 106 ? 32.71697  8.06368   42.77926  1.000 20.67447 ? 461  GLN   A C   1 
ATOM   735  O O   . GLN   A 1 106 ? 33.95460  8.10939   42.80046  1.000 20.10411 ? 461  GLN   A O   1 
ATOM   736  C CB  . GLN   A 1 106 ? 31.90023  6.41024   41.15479  1.000 18.53361 ? 461  GLN   A CB  1 
ATOM   737  C CG  . GLN   A 1 106 ? 31.49639  4.94162   40.82852  1.000 16.68305 ? 461  GLN   A CG  1 
ATOM   738  C CD  . GLN   A 1 106 ? 30.90024  4.83758   39.43102  1.000 23.27309 ? 461  GLN   A CD  1 
ATOM   739  O OE1 . GLN   A 1 106 ? 30.99207  5.76104   38.61449  1.000 27.08722 ? 461  GLN   A OE1 1 
ATOM   740  N NE2 . GLN   A 1 106 ? 30.28062  3.68371   39.14154  1.000 21.51954 ? 461  GLN   A NE2 1 
ATOM   741  N N   . GLN   A 1 107 ? 31.94906  9.15452   42.72796  1.000 16.01861 ? 462  GLN   A N   1 
ATOM   742  C CA  . GLN   A 1 107 ? 32.46446  10.52146  42.77130  1.000 17.23190 ? 462  GLN   A CA  1 
ATOM   743  C C   . GLN   A 1 107 ? 32.62552  11.04727  44.18500  1.000 20.64134 ? 462  GLN   A C   1 
ATOM   744  O O   . GLN   A 1 107 ? 33.15362  12.16102  44.34596  1.000 22.39944 ? 462  GLN   A O   1 
ATOM   745  C CB  . GLN   A 1 107 ? 31.53857  11.45988  42.03078  1.000 21.19472 ? 462  GLN   A CB  1 
ATOM   746  C CG  . GLN   A 1 107 ? 31.39021  11.19957  40.56638  1.000 26.43930 ? 462  GLN   A CG  1 
ATOM   747  C CD  . GLN   A 1 107 ? 32.63844  11.55546  39.79728  1.000 45.57417 ? 462  GLN   A CD  1 
ATOM   748  O OE1 . GLN   A 1 107 ? 33.09290  10.78741  38.95921  1.000 43.16632 ? 462  GLN   A OE1 1 
ATOM   749  N NE2 . GLN   A 1 107 ? 33.20752  12.72341  40.08955  1.000 49.74510 ? 462  GLN   A NE2 1 
ATOM   750  N N   . ASN   A 1 108 ? 32.16405  10.32139  45.20017  1.000 18.84000 ? 463  ASN   A N   1 
ATOM   751  C CA  . ASN   A 1 108 ? 32.10426  10.77647  46.60285  1.000 17.90761 ? 463  ASN   A CA  1 
ATOM   752  C C   . ASN   A 1 108 ? 32.47436  9.59458   47.47840  1.000 20.89975 ? 463  ASN   A C   1 
ATOM   753  O O   . ASN   A 1 108 ? 31.67920  9.01791   48.23655  1.000 20.55558 ? 463  ASN   A O   1 
ATOM   754  C CB  . ASN   A 1 108 ? 30.72975  11.33786  46.97584  1.000 18.20365 ? 463  ASN   A CB  1 
ATOM   755  C CG  . ASN   A 1 108 ? 30.41161  12.56390  46.18554  1.000 20.76787 ? 463  ASN   A CG  1 
ATOM   756  O OD1 . ASN   A 1 108 ? 30.86737  13.66863  46.54120  1.000 26.18892 ? 463  ASN   A OD1 1 
ATOM   757  N ND2 . ASN   A 1 108 ? 29.67717  12.41672  45.09815  1.000 18.60031 ? 463  ASN   A ND2 1 
ATOM   758  N N   . ARG   A 1 109 ? 33.74650  9.21359   47.36966  1.000 19.64565 ? 464  ARG   A N   1 
ATOM   759  C CA  . ARG   A 1 109 ? 34.27029  7.99936   47.98984  1.000 24.32593 ? 464  ARG   A CA  1 
ATOM   760  C C   . ARG   A 1 109 ? 34.39463  8.08333   49.49619  1.000 26.10445 ? 464  ARG   A C   1 
ATOM   761  O O   . ARG   A 1 109 ? 34.70587  7.06143   50.12130  1.000 29.66590 ? 464  ARG   A O   1 
ATOM   762  C CB  . ARG   A 1 109 ? 35.65640  7.68733   47.39895  1.000 28.24754 ? 464  ARG   A CB  1 
ATOM   763  C CG  . ARG   A 1 109 ? 35.63296  7.51069   45.91743  1.000 31.36368 ? 464  ARG   A CG  1 
ATOM   764  C CD  . ARG   A 1 109 ? 35.11505  6.12658   45.59222  1.000 31.03082 ? 464  ARG   A CD  1 
ATOM   765  N NE  . ARG   A 1 109 ? 35.51332  5.20239   46.64920  1.000 43.98098 ? 464  ARG   A NE  1 
ATOM   766  C CZ  . ARG   A 1 109 ? 35.83202  3.92483   46.47841  1.000 40.82872 ? 464  ARG   A CZ  1 
ATOM   767  N NH1 . ARG   A 1 109 ? 35.87167  3.37346   45.27799  1.000 43.02199 ? 464  ARG   A NH1 1 
ATOM   768  N NH2 . ARG   A 1 109 ? 36.10211  3.17649   47.54872  1.000 43.54226 ? 464  ARG   A NH2 1 
ATOM   769  N N   . HIS   A 1 110 ? 34.18087  9.25541   50.09858  1.000 24.00661 ? 465  HIS   A N   1 
ATOM   770  C CA  . HIS   A 1 110 ? 34.27836  9.41445   51.54284  1.000 26.64137 ? 465  HIS   A CA  1 
ATOM   771  C C   . HIS   A 1 110 ? 32.91074  9.55019   52.22305  1.000 23.70384 ? 465  HIS   A C   1 
ATOM   772  O O   . HIS   A 1 110 ? 32.85140  9.90757   53.40296  1.000 26.12674 ? 465  HIS   A O   1 
ATOM   773  C CB  . HIS   A 1 110 ? 35.14974  10.62912  51.87095  1.000 29.56973 ? 465  HIS   A CB  1 
ATOM   774  C CG  . HIS   A 1 110 ? 36.50125  10.59677  51.22488  1.000 42.02058 ? 465  HIS   A CG  1 
ATOM   775  N ND1 . HIS   A 1 110 ? 37.00520  9.47287   50.60343  1.000 42.40203 ? 465  HIS   A ND1 1 
ATOM   776  C CD2 . HIS   A 1 110 ? 37.45720  11.54856  51.11105  1.000 47.05089 ? 465  HIS   A CD2 1 
ATOM   777  C CE1 . HIS   A 1 110 ? 38.20942  9.73608   50.12689  1.000 48.00997 ? 465  HIS   A CE1 1 
ATOM   778  N NE2 . HIS   A 1 110 ? 38.50967  10.98710  50.42653  1.000 51.85685 ? 465  HIS   A NE2 1 
ATOM   779  N N   . VAL   A 1 111 ? 31.80846  9.26448   51.50862  1.000 19.87280 ? 466  VAL   A N   1 
ATOM   780  C CA  . VAL   A 1 111 ? 30.51561  9.13686   52.16304  1.000 19.03147 ? 466  VAL   A CA  1 
ATOM   781  C C   . VAL   A 1 111 ? 30.67019  8.09302   53.25386  1.000 18.75081 ? 466  VAL   A C   1 
ATOM   782  O O   . VAL   A 1 111 ? 31.29019  7.03543   53.04214  1.000 22.37610 ? 466  VAL   A O   1 
ATOM   783  C CB  . VAL   A 1 111 ? 29.42711  8.72975   51.14381  1.000 16.55572 ? 466  VAL   A CB  1 
ATOM   784  C CG1 . VAL   A 1 111 ? 28.11200  8.29497   51.82329  1.000 22.74562 ? 466  VAL   A CG1 1 
ATOM   785  C CG2 . VAL   A 1 111 ? 29.17423  9.87671   50.14103  1.000 17.43971 ? 466  VAL   A CG2 1 
ATOM   786  N N   . LYS   A 1 112 ? 30.07725  8.36619   54.41627  1.000 18.15473 ? 467  LYS   A N   1 
ATOM   787  C CA  . LYS   A 1 112 ? 30.31844  7.52792   55.56967  1.000 20.80463 ? 467  LYS   A CA  1 
ATOM   788  C C   . LYS   A 1 112 ? 29.49245  6.24807   55.51442  1.000 18.24367 ? 467  LYS   A C   1 
ATOM   789  O O   . LYS   A 1 112 ? 28.39063  6.20750   54.92429  1.000 17.16785 ? 467  LYS   A O   1 
ATOM   790  C CB  . LYS   A 1 112 ? 29.98709  8.29520   56.83826  1.000 25.08835 ? 467  LYS   A CB  1 
ATOM   791  C CG  . LYS   A 1 112 ? 30.87830  9.53388   57.05394  1.000 26.82589 ? 467  LYS   A CG  1 
ATOM   792  C CD  . LYS   A 1 112 ? 32.33240  9.13624   57.10861  1.000 39.77866 ? 467  LYS   A CD  1 
ATOM   793  C CE  . LYS   A 1 112 ? 33.22065  10.32297  57.49774  1.000 51.37157 ? 467  LYS   A CE  1 
ATOM   794  N NZ  . LYS   A 1 112 ? 34.59690  9.87324   57.87232  1.000 63.01948 ? 467  LYS   A NZ  1 
ATOM   795  N N   . ASP   A 1 113 ? 29.99598  5.20685   56.18052  1.000 18.73163 ? 468  ASP   A N   1 
ATOM   796  C CA  . ASP   A 1 113 ? 29.24366  3.95939   56.23979  1.000 18.14132 ? 468  ASP   A CA  1 
ATOM   797  C C   . ASP   A 1 113 ? 27.82138  4.15583   56.78274  1.000 18.41808 ? 468  ASP   A C   1 
ATOM   798  O O   . ASP   A 1 113 ? 26.85584  3.56153   56.27662  1.000 16.67722 ? 468  ASP   A O   1 
ATOM   799  C CB  . ASP   A 1 113 ? 30.01233  2.93878   57.08851  1.000 17.55655 ? 468  ASP   A CB  1 
ATOM   800  C CG  . ASP   A 1 113 ? 29.38899  1.56971   57.02503  1.000 23.20940 ? 468  ASP   A CG  1 
ATOM   801  O OD1 . ASP   A 1 113 ? 29.54705  0.91353   55.94061  1.000 27.53463 ? 468  ASP   A OD1 1 
ATOM   802  O OD2 . ASP   A 1 113 ? 28.75461  1.18040   58.02286  1.000 24.17572 ? 468  ASP   A OD2 1 
ATOM   803  N N   . LYS   A 1 114 ? 27.65409  4.96756   57.82518  1.000 17.88949 ? 469  LYS   A N   1 
ATOM   804  C CA  . LYS   A 1 114 ? 26.32456  5.18356   58.36115  1.000 16.27303 ? 469  LYS   A CA  1 
ATOM   805  C C   . LYS   A 1 114 ? 25.39359  5.77363   57.30041  1.000 16.09322 ? 469  LYS   A C   1 
ATOM   806  O O   . LYS   A 1 114 ? 24.20435  5.43890   57.26273  1.000 16.77823 ? 469  LYS   A O   1 
ATOM   807  C CB  . LYS   A 1 114 ? 26.43289  6.12201   59.58262  1.000 19.71581 ? 469  LYS   A CB  1 
ATOM   808  C CG  . LYS   A 1 114 ? 25.12255  6.51712   60.24914  1.000 25.02061 ? 469  LYS   A CG  1 
ATOM   809  C CD  . LYS   A 1 114 ? 25.39972  7.62847   61.31431  1.000 30.20095 ? 469  LYS   A CD  1 
ATOM   810  C CE  . LYS   A 1 114 ? 24.12368  8.09110   61.99208  1.000 38.70505 ? 469  LYS   A CE  1 
ATOM   811  N NZ  . LYS   A 1 114 ? 24.40111  9.17260   62.98910  1.000 47.43221 ? 469  LYS   A NZ  1 
ATOM   812  N N   . ASN   A 1 115 ? 25.92566  6.65746   56.44847  1.000 14.90459 ? 470  ASN   A N   1 
ATOM   813  C CA  . ASN   A 1 115 ? 25.14767  7.27969   55.36830  1.000 16.33696 ? 470  ASN   A CA  1 
ATOM   814  C C   . ASN   A 1 115 ? 24.74069  6.23123   54.32826  1.000 15.33513 ? 470  ASN   A C   1 
ATOM   815  O O   . ASN   A 1 115 ? 23.62312  6.25087   53.80841  1.000 14.25514 ? 470  ASN   A O   1 
ATOM   816  C CB  . ASN   A 1 115 ? 26.03934  8.35549   54.76777  1.000 18.52190 ? 470  ASN   A CB  1 
ATOM   817  C CG  . ASN   A 1 115 ? 25.31164  9.39716   53.92123  1.000 21.15876 ? 470  ASN   A CG  1 
ATOM   818  O OD1 . ASN   A 1 115 ? 25.89946  10.47435  53.65882  1.000 21.79459 ? 470  ASN   A OD1 1 
ATOM   819  N ND2 . ASN   A 1 115 ? 24.09402  9.08864   53.43090  1.000 16.02976 ? 470  ASN   A ND2 1 
ATOM   820  N N   . ILE   A 1 116 ? 25.61761  5.28057   54.05673  1.000 15.78157 ? 471  ILE   A N   1 
ATOM   821  C CA  . ILE   A 1 116 ? 25.25935  4.21257   53.10839  1.000 12.91654 ? 471  ILE   A CA  1 
ATOM   822  C C   . ILE   A 1 116 ? 24.16895  3.35522   53.69828  1.000 13.06423 ? 471  ILE   A C   1 
ATOM   823  O O   . ILE   A 1 116 ? 23.19779  2.98253   53.00337  1.000 13.09625 ? 471  ILE   A O   1 
ATOM   824  C CB  . ILE   A 1 116 ? 26.48727  3.38513   52.74562  1.000 13.01866 ? 471  ILE   A CB  1 
ATOM   825  C CG1 . ILE   A 1 116 ? 27.52811  4.26983   52.10910  1.000 15.66174 ? 471  ILE   A CG1 1 
ATOM   826  C CG2 . ILE   A 1 116 ? 26.10706  2.17991   51.80858  1.000 14.07988 ? 471  ILE   A CG2 1 
ATOM   827  C CD1 . ILE   A 1 116 ? 28.86480  3.58766   51.90817  1.000 23.95793 ? 471  ILE   A CD1 1 
ATOM   828  N N   . ILE   A 1 117 ? 24.26959  3.01902   55.00531  1.000 13.39102 ? 472  ILE   A N   1 
ATOM   829  C CA  . ILE   A 1 117 ? 23.19219  2.26880   55.64177  1.000 12.76460 ? 472  ILE   A CA  1 
ATOM   830  C C   . ILE   A 1 117 ? 21.87737  3.02902   55.53640  1.000 14.38955 ? 472  ILE   A C   1 
ATOM   831  O O   . ILE   A 1 117 ? 20.83542  2.44105   55.21866  1.000 14.42912 ? 472  ILE   A O   1 
ATOM   832  C CB  . ILE   A 1 117 ? 23.52532  1.95661   57.12288  1.000 14.00362 ? 472  ILE   A CB  1 
ATOM   833  C CG1 . ILE   A 1 117 ? 24.73567  1.05835   57.19424  1.000 16.82734 ? 472  ILE   A CG1 1 
ATOM   834  C CG2 . ILE   A 1 117 ? 22.34519  1.31320   57.78350  1.000 15.51515 ? 472  ILE   A CG2 1 
ATOM   835  C CD1 . ILE   A 1 117 ? 25.36181  1.05241   58.56770  1.000 19.33086 ? 472  ILE   A CD1 1 
ATOM   836  N N   . GLU   A 1 118 ? 21.90637  4.34315   55.82631  1.000 13.54272 ? 473  GLU   A N   1 
ATOM   837  C CA  . GLU   A 1 118 ? 20.68591  5.16675   55.71087  1.000 14.34950 ? 473  GLU   A CA  1 
ATOM   838  C C   . GLU   A 1 118 ? 20.02618  5.03577   54.33473  1.000 14.53148 ? 473  GLU   A C   1 
ATOM   839  O O   . GLU   A 1 118 ? 18.81055  4.81970   54.22389  1.000 14.20927 ? 473  GLU   A O   1 
ATOM   840  C CB  . GLU   A 1 118 ? 21.07856  6.61026   55.97693  1.000 13.64138 ? 473  GLU   A CB  1 
ATOM   841  C CG  . GLU   A 1 118 ? 19.91297  7.60179   55.90527  1.000 15.90100 ? 473  GLU   A CG  1 
ATOM   842  C CD  . GLU   A 1 118 ? 20.39229  9.03296   56.12763  1.000 20.34254 ? 473  GLU   A CD  1 
ATOM   843  O OE1 . GLU   A 1 118 ? 21.56256  9.34461   55.80323  1.000 21.74622 ? 473  GLU   A OE1 1 
ATOM   844  O OE2 . GLU   A 1 118 ? 19.57179  9.84863   56.56741  1.000 25.05948 ? 473  GLU   A OE2 1 
ATOM   845  N N   . LEU   A 1 119 ? 20.83766  5.15370   53.29269  1.000 13.11151 ? 474  LEU   A N   1 
ATOM   846  C CA  . LEU   A 1 119 ? 20.30139  5.14963   51.92976  1.000 11.35380 ? 474  LEU   A CA  1 
ATOM   847  C C   . LEU   A 1 119 ? 19.78035  3.76225   51.56283  1.000 12.21659 ? 474  LEU   A C   1 
ATOM   848  O O   . LEU   A 1 119 ? 18.70302  3.64426   50.95670  1.000 12.29864 ? 474  LEU   A O   1 
ATOM   849  C CB  . LEU   A 1 119 ? 21.36760  5.58793   50.95473  1.000 13.22378 ? 474  LEU   A CB  1 
ATOM   850  C CG  . LEU   A 1 119 ? 21.81126  7.04060   51.14879  1.000 14.02028 ? 474  LEU   A CG  1 
ATOM   851  C CD1 . LEU   A 1 119 ? 23.03980  7.27262   50.31273  1.000 13.76101 ? 474  LEU   A CD1 1 
ATOM   852  C CD2 . LEU   A 1 119 ? 20.65509  8.00412   50.78075  1.000 15.69936 ? 474  LEU   A CD2 1 
ATOM   853  N N   . VAL   A 1 120 ? 20.51715  2.68044   51.90465  1.000 12.37119 ? 475  VAL   A N   1 
ATOM   854  C CA  . VAL   A 1 120 ? 19.98571  1.37978   51.49662  1.000 11.42389 ? 475  VAL   A CA  1 
ATOM   855  C C   . VAL   A 1 120 ? 18.74619  1.02600   52.31216  1.000 12.60706 ? 475  VAL   A C   1 
ATOM   856  O O   . VAL   A 1 120 ? 17.84365  0.35891   51.81777  1.000 14.01140 ? 475  VAL   A O   1 
ATOM   857  C CB  . VAL   A 1 120 ? 21.03608  0.24804   51.53251  1.000 18.99252 ? 475  VAL   A CB  1 
ATOM   858  C CG1 . VAL   A 1 120 ? 22.15647  0.53115   50.56208  1.000 16.21970 ? 475  VAL   A CG1 1 
ATOM   859  C CG2 . VAL   A 1 120 ? 21.55693  0.02774   52.84624  1.000 19.62351 ? 475  VAL   A CG2 1 
ATOM   860  N N   . HIS   A 1 121 ? 18.66379  1.51492   53.55652  1.000 12.76885 ? 476  HIS   A N   1 
ATOM   861  C CA  . HIS   A 1 121 ? 17.44245  1.30939   54.31741  1.000 14.00891 ? 476  HIS   A CA  1 
ATOM   862  C C   . HIS   A 1 121 ? 16.26523  2.01702   53.64754  1.000 12.55928 ? 476  HIS   A C   1 
ATOM   863  O O   . HIS   A 1 121 ? 15.18152  1.45704   53.55226  1.000 13.56461 ? 476  HIS   A O   1 
ATOM   864  C CB  . HIS   A 1 121 ? 17.62515  1.82859   55.75106  1.000 14.91122 ? 476  HIS   A CB  1 
ATOM   865  C CG  . HIS   A 1 121 ? 16.36832  1.72945   56.54065  1.000 15.22435 ? 476  HIS   A CG  1 
ATOM   866  N ND1 . HIS   A 1 121 ? 15.82935  2.82146   57.19094  1.000 19.12591 ? 476  HIS   A ND1 1 
ATOM   867  C CD2 . HIS   A 1 121 ? 15.49137  0.72235   56.70090  1.000 15.50084 ? 476  HIS   A CD2 1 
ATOM   868  C CE1 . HIS   A 1 121 ? 14.65816  2.48228   57.71234  1.000 15.36478 ? 476  HIS   A CE1 1 
ATOM   869  N NE2 . HIS   A 1 121 ? 14.45832  1.20119   57.48072  1.000 16.55842 ? 476  HIS   A NE2 1 
ATOM   870  N N   . GLN   A 1 122 ? 16.47260  3.23805   53.17877  1.000 12.04434 ? 477  GLN   A N   1 
ATOM   871  C CA  . GLN   A 1 122 ? 15.42708  3.94347   52.40611  1.000 12.18360 ? 477  GLN   A CA  1 
ATOM   872  C C   . GLN   A 1 122 ? 14.98087  3.10737   51.21129  1.000 12.52746 ? 477  GLN   A C   1 
ATOM   873  O O   . GLN   A 1 122 ? 13.78946  2.93594   50.95793  1.000 12.51001 ? 477  GLN   A O   1 
ATOM   874  C CB  . GLN   A 1 122 ? 15.91033  5.32039   51.97338  1.000 12.92368 ? 477  GLN   A CB  1 
ATOM   875  C CG  . GLN   A 1 122 ? 15.94944  6.31275   53.17937  1.000 13.71389 ? 477  GLN   A CG  1 
ATOM   876  C CD  . GLN   A 1 122 ? 16.71383  7.53703   52.89753  1.000 16.42055 ? 477  GLN   A CD  1 
ATOM   877  O OE1 . GLN   A 1 122 ? 17.31058  7.68969   51.82953  1.000 17.10847 ? 477  GLN   A OE1 1 
ATOM   878  N NE2 . GLN   A 1 122 ? 16.74016  8.45831   53.86205  1.000 18.92565 ? 477  GLN   A NE2 1 
ATOM   879  N N   . VAL   A 1 123 ? 15.93475  2.54230   50.46839  1.000 11.19398 ? 478  VAL   A N   1 
ATOM   880  C CA  . VAL   A 1 123 ? 15.54186  1.68253   49.34175  1.000 13.13976 ? 478  VAL   A CA  1 
ATOM   881  C C   . VAL   A 1 123 ? 14.70909  0.50263   49.82410  1.000 10.37564 ? 478  VAL   A C   1 
ATOM   882  O O   . VAL   A 1 123 ? 13.68267  0.16892   49.21749  1.000 12.04367 ? 478  VAL   A O   1 
ATOM   883  C CB  . VAL   A 1 123 ? 16.80472  1.21726   48.58118  1.000 10.87759 ? 478  VAL   A CB  1 
ATOM   884  C CG1 . VAL   A 1 123 ? 16.47243  0.19461   47.52446  1.000 12.87715 ? 478  VAL   A CG1 1 
ATOM   885  C CG2 . VAL   A 1 123 ? 17.48239  2.41940   47.91472  1.000 12.44667 ? 478  VAL   A CG2 1 
ATOM   886  N N   . SER   A 1 124 ? 15.06328  -0.09571  50.95622  1.000 11.25375 ? 479  SER   A N   1 
ATOM   887  C CA  . SER   A 1 124 ? 14.29175  -1.21440  51.48513  1.000 12.02004 ? 479  SER   A CA  1 
ATOM   888  C C   . SER   A 1 124 ? 12.88910  -0.78886  51.95306  1.000 13.76019 ? 479  SER   A C   1 
ATOM   889  O O   . SER   A 1 124 ? 11.95272  -1.59373  51.84083  1.000 14.01085 ? 479  SER   A O   1 
ATOM   890  C CB  . SER   A 1 124 ? 15.06589  -1.91947  52.61915  1.000 12.75580 ? 479  SER   A CB  1 
ATOM   891  O OG  . SER   A 1 124 ? 14.93103  -1.24922  53.87942  1.000 13.95051 ? 479  SER   A OG  1 
ATOM   892  N N   . MET   A 1 125 ? 12.70795  0.47041   52.37446  1.000 12.69462 ? 480  MET   A N   1 
ATOM   893  C CA  . MET   A 1 125 ? 11.34965  0.96484   52.64906  1.000 15.18850 ? 480  MET   A CA  1 
ATOM   894  C C   . MET   A 1 125 ? 10.54113  1.10756   51.35719  1.000 14.56205 ? 480  MET   A C   1 
ATOM   895  O O   . MET   A 1 125 ? 9.35617   0.71254   51.30142  1.000 15.87939 ? 480  MET   A O   1 
ATOM   896  C CB  . MET   A 1 125 ? 11.42911  2.28055   53.41764  1.000 17.16636 ? 480  MET   A CB  1 
ATOM   897  C CG  . MET   A 1 125 ? 11.94470  2.02121   54.84328  1.000 15.36904 ? 480  MET   A CG  1 
ATOM   898  S SD  . MET   A 1 125 ? 11.83984  3.55863   55.87339  1.000 22.16382 ? 480  MET   A SD  1 
ATOM   899  C CE  . MET   A 1 125 ? 13.09778  4.42125   55.19749  1.000 18.34692 ? 480  MET   A CE  1 
ATOM   900  N N   . GLY   A 1 126 ? 11.14731  1.65855   50.29926  1.000 12.93894 ? 481  GLY   A N   1 
ATOM   901  C CA  . GLY   A 1 126 ? 10.40327  1.74544   49.04728  1.000 13.67021 ? 481  GLY   A CA  1 
ATOM   902  C C   . GLY   A 1 126 ? 10.04898  0.36671   48.51390  1.000 16.16175 ? 481  GLY   A C   1 
ATOM   903  O O   . GLY   A 1 126 ? 8.93726   0.13458   48.01723  1.000 14.08546 ? 481  GLY   A O   1 
ATOM   904  N N   . MET   A 1 127 ? 10.97235  -0.59813  48.66299  1.000 13.60838 ? 482  MET   A N   1 
ATOM   905  C CA  . MET   A 1 127 ? 10.69085  -1.94976  48.20213  1.000 13.65640 ? 482  MET   A CA  1 
ATOM   906  C C   . MET   A 1 127 ? 9.68403   -2.69145  49.06292  1.000 12.81847 ? 482  MET   A C   1 
ATOM   907  O O   . MET   A 1 127 ? 8.91974   -3.48851  48.53139  1.000 14.49940 ? 482  MET   A O   1 
ATOM   908  C CB  . MET   A 1 127 ? 12.01283  -2.70717  48.11590  1.000 12.99397 ? 482  MET   A CB  1 
ATOM   909  C CG  . MET   A 1 127 ? 12.88962  -2.22691  46.93914  1.000 12.01264 ? 482  MET   A CG  1 
ATOM   910  S SD  . MET   A 1 127 ? 12.09867  -2.20868  45.32239  1.000 14.56528 ? 482  MET   A SD  1 
ATOM   911  C CE  . MET   A 1 127 ? 11.60518  -3.93760  45.15885  1.000 13.87265 ? 482  MET   A CE  1 
ATOM   912  N N   . LYS   A 1 128 ? 9.65988   -2.43227  50.36626  1.000 14.13225 ? 483  LYS   A N   1 
ATOM   913  C CA  . LYS   A 1 128 ? 8.60384   -3.00903  51.20975  1.000 13.32023 ? 483  LYS   A CA  1 
ATOM   914  C C   . LYS   A 1 128 ? 7.23424   -2.53123  50.73750  1.000 15.11825 ? 483  LYS   A C   1 
ATOM   915  O O   . LYS   A 1 128 ? 6.28436   -3.31620  50.66002  1.000 15.06622 ? 483  LYS   A O   1 
ATOM   916  C CB  . LYS   A 1 128 ? 8.85830   -2.60345  52.65823  1.000 16.83592 ? 483  LYS   A CB  1 
ATOM   917  C CG  . LYS   A 1 128 ? 7.82344   -3.11690  53.68336  1.000 16.71403 ? 483  LYS   A CG  1 
ATOM   918  C CD  . LYS   A 1 128 ? 8.31142   -2.70572  55.11965  1.000 20.65573 ? 483  LYS   A CD  1 
ATOM   919  C CE  . LYS   A 1 128 ? 7.18217   -2.65294  56.13399  1.000 32.44659 ? 483  LYS   A CE  1 
ATOM   920  N NZ  . LYS   A 1 128 ? 6.64653   -4.00042  56.33590  1.000 40.00614 ? 483  LYS   A NZ  1 
ATOM   921  N N   . TYR   A 1 129 ? 7.13591   -1.24700  50.41250  1.000 14.10281 ? 484  TYR   A N   1 
ATOM   922  C CA  . TYR   A 1 129 ? 5.90514   -0.72945  49.80476  1.000 14.73011 ? 484  TYR   A CA  1 
ATOM   923  C C   . TYR   A 1 129 ? 5.60082   -1.37504  48.44656  1.000 15.85969 ? 484  TYR   A C   1 
ATOM   924  O O   . TYR   A 1 129 ? 4.44715   -1.72292  48.15615  1.000 17.91182 ? 484  TYR   A O   1 
ATOM   925  C CB  . TYR   A 1 129 ? 6.01379   0.78000   49.68004  1.000 16.63977 ? 484  TYR   A CB  1 
ATOM   926  C CG  . TYR   A 1 129 ? 4.90136   1.35261   48.81663  1.000 18.51128 ? 484  TYR   A CG  1 
ATOM   927  C CD1 . TYR   A 1 129 ? 3.65433   1.62429   49.35032  1.000 21.41379 ? 484  TYR   A CD1 1 
ATOM   928  C CD2 . TYR   A 1 129 ? 5.12696   1.61837   47.49445  1.000 17.18636 ? 484  TYR   A CD2 1 
ATOM   929  C CE1 . TYR   A 1 129 ? 2.65601   2.17202   48.56794  1.000 18.21106 ? 484  TYR   A CE1 1 
ATOM   930  C CE2 . TYR   A 1 129 ? 4.10937   2.12968   46.67730  1.000 18.80843 ? 484  TYR   A CE2 1 
ATOM   931  C CZ  . TYR   A 1 129 ? 2.88878   2.39383   47.24311  1.000 21.24253 ? 484  TYR   A CZ  1 
ATOM   932  O OH  . TYR   A 1 129 ? 1.90663   2.92279   46.48996  1.000 22.42179 ? 484  TYR   A OH  1 
ATOM   933  N N   . LEU   A 1 130 ? 6.60087   -1.50203  47.57023  1.000 13.89220 ? 485  LEU   A N   1 
ATOM   934  C CA  . LEU   A 1 130 ? 6.32527   -2.12145  46.28598  1.000 14.87385 ? 485  LEU   A CA  1 
ATOM   935  C C   . LEU   A 1 130 ? 5.81866   -3.54791  46.46630  1.000 16.22439 ? 485  LEU   A C   1 
ATOM   936  O O   . LEU   A 1 130 ? 4.86166   -3.96348  45.77506  1.000 16.43082 ? 485  LEU   A O   1 
ATOM   937  C CB  . LEU   A 1 130 ? 7.59890   -2.05366  45.43239  1.000 16.20422 ? 485  LEU   A CB  1 
ATOM   938  C CG  . LEU   A 1 130 ? 7.39546   -2.13780  43.94714  1.000 23.20155 ? 485  LEU   A CG  1 
ATOM   939  C CD1 . LEU   A 1 130 ? 6.69653   -0.86664  43.48049  1.000 21.09731 ? 485  LEU   A CD1 1 
ATOM   940  C CD2 . LEU   A 1 130 ? 8.78085   -2.28141  43.31775  1.000 22.84632 ? 485  LEU   A CD2 1 
ATOM   941  N N   . GLU   A 1 131 ? 6.42668   -4.30888  47.40398  1.000 16.87507 ? 486  GLU   A N   1 
ATOM   942  C CA  . GLU   A 1 131 ? 5.99895   -5.66409  47.70171  1.000 16.22670 ? 486  GLU   A CA  1 
ATOM   943  C C   . GLU   A 1 131 ? 4.55986   -5.69715  48.20877  1.000 16.58375 ? 486  GLU   A C   1 
ATOM   944  O O   . GLU   A 1 131 ? 3.76881   -6.53242  47.75820  1.000 18.15858 ? 486  GLU   A O   1 
ATOM   945  C CB  . GLU   A 1 131 ? 6.95052   -6.27919  48.73132  1.000 16.83849 ? 486  GLU   A CB  1 
ATOM   946  C CG  . GLU   A 1 131 ? 6.56270   -7.64341  49.24699  1.000 16.30112 ? 486  GLU   A CG  1 
ATOM   947  C CD  . GLU   A 1 131 ? 7.58609   -8.06965  50.26865  1.000 24.68594 ? 486  GLU   A CD  1 
ATOM   948  O OE1 . GLU   A 1 131 ? 7.43820   -7.70191  51.47440  1.000 28.78834 ? 486  GLU   A OE1 1 
ATOM   949  O OE2 . GLU   A 1 131 ? 8.58872   -8.67112  49.83518  1.000 24.76889 ? 486  GLU   A OE2 1 
ATOM   950  N N   . GLU   A 1 132 ? 4.22088   -4.80264  49.14219  1.000 15.32514 ? 487  GLU   A N   1 
ATOM   951  C CA  . GLU   A 1 132 ? 2.84689   -4.73940  49.65115  1.000 17.29678 ? 487  GLU   A CA  1 
ATOM   952  C C   . GLU   A 1 132 ? 1.88121   -4.41688  48.52924  1.000 20.04354 ? 487  GLU   A C   1 
ATOM   953  O O   . GLU   A 1 132 ? 0.72410   -4.84825  48.57578  1.000 20.92437 ? 487  GLU   A O   1 
ATOM   954  C CB  . GLU   A 1 132 ? 2.72992   -3.68827  50.75477  1.000 20.84260 ? 487  GLU   A CB  1 
ATOM   955  C CG  . GLU   A 1 132 ? 3.48541   -4.03044  52.05202  1.000 25.31408 ? 487  GLU   A CG  1 
ATOM   956  C CD  . GLU   A 1 132 ? 3.73452   -2.81611  52.95571  1.000 34.03518 ? 487  GLU   A CD  1 
ATOM   957  O OE1 . GLU   A 1 132 ? 3.56683   -1.65191  52.51121  1.000 39.78969 ? 487  GLU   A OE1 1 
ATOM   958  O OE2 . GLU   A 1 132 ? 4.12024   -3.01133  54.13019  1.000 37.17280 ? 487  GLU   A OE2 1 
ATOM   959  N N   . SER   A 1 133 ? 2.31906   -3.65434  47.51740  1.000 16.51750 ? 488  SER   A N   1 
ATOM   960  C CA  . SER   A 1 133 ? 1.49315   -3.22749  46.38336  1.000 16.85382 ? 488  SER   A CA  1 
ATOM   961  C C   . SER   A 1 133 ? 1.44494   -4.27007  45.27663  1.000 16.96060 ? 488  SER   A C   1 
ATOM   962  O O   . SER   A 1 133 ? 0.75072   -4.06962  44.25775  1.000 19.91040 ? 488  SER   A O   1 
ATOM   963  C CB  . SER   A 1 133 ? 2.01835   -1.90522  45.82947  1.000 18.36852 ? 488  SER   A CB  1 
ATOM   964  O OG  . SER   A 1 133 ? 2.05074   -0.90831  46.84397  1.000 19.86377 ? 488  SER   A OG  1 
ATOM   965  N N   . ASN   A 1 134 ? 2.14397   -5.38707  45.45347  1.000 16.78882 ? 489  ASN   A N   1 
ATOM   966  C CA  . ASN   A 1 134 ? 2.16191   -6.50875  44.50530  1.000 18.76718 ? 489  ASN   A CA  1 
ATOM   967  C C   . ASN   A 1 134 ? 2.67170   -6.08361  43.12889  1.000 15.51395 ? 489  ASN   A C   1 
ATOM   968  O O   . ASN   A 1 134 ? 2.19060   -6.52546  42.08284  1.000 15.93090 ? 489  ASN   A O   1 
ATOM   969  C CB  . ASN   A 1 134 ? 0.77941   -7.18337  44.44438  1.000 20.65498 ? 489  ASN   A CB  1 
ATOM   970  C CG  . ASN   A 1 134 ? 0.41932   -7.84990  45.77954  1.000 22.64850 ? 489  ASN   A CG  1 
ATOM   971  O OD1 . ASN   A 1 134 ? 1.19345   -8.61298  46.30896  1.000 28.89904 ? 489  ASN   A OD1 1 
ATOM   972  N ND2 . ASN   A 1 134 ? -0.72706  -7.48985  46.33548  1.000 37.20562 ? 489  ASN   A ND2 1 
ATOM   973  N N   . PHE   A 1 135 ? 3.75011   -5.27444  43.12132  1.000 14.34130 ? 490  PHE   A N   1 
ATOM   974  C CA  . PHE   A 1 135 ? 4.50537   -4.99740  41.90509  1.000 13.50879 ? 490  PHE   A CA  1 
ATOM   975  C C   . PHE   A 1 135 ? 5.88391   -5.61648  42.06910  1.000 14.66900 ? 490  PHE   A C   1 
ATOM   976  O O   . PHE   A 1 135 ? 6.42066   -5.63037  43.18152  1.000 16.05333 ? 490  PHE   A O   1 
ATOM   977  C CB  . PHE   A 1 135 ? 4.70856   -3.49839  41.64616  1.000 15.09499 ? 490  PHE   A CB  1 
ATOM   978  C CG  . PHE   A 1 135 ? 3.48657   -2.79729  41.14577  1.000 15.46355 ? 490  PHE   A CG  1 
ATOM   979  C CD1 . PHE   A 1 135 ? 2.54527   -2.30778  42.03398  1.000 20.71059 ? 490  PHE   A CD1 1 
ATOM   980  C CD2 . PHE   A 1 135 ? 3.30074   -2.65879  39.78711  1.000 18.71905 ? 490  PHE   A CD2 1 
ATOM   981  C CE1 . PHE   A 1 135 ? 1.39340   -1.67338  41.54943  1.000 24.37638 ? 490  PHE   A CE1 1 
ATOM   982  C CE2 . PHE   A 1 135 ? 2.16285   -2.03142  39.30171  1.000 23.55830 ? 490  PHE   A CE2 1 
ATOM   983  C CZ  . PHE   A 1 135 ? 1.23193   -1.55174  40.19469  1.000 17.51065 ? 490  PHE   A CZ  1 
ATOM   984  N N   . VAL   A 1 136 ? 6.42817   -6.13637  40.99725  1.000 11.83212 ? 491  VAL   A N   1 
ATOM   985  C CA  . VAL   A 1 136 ? 7.83450   -6.56064  40.97400  1.000 12.47729 ? 491  VAL   A CA  1 
ATOM   986  C C   . VAL   A 1 136 ? 8.60763   -5.55367  40.14424  1.000 13.86872 ? 491  VAL   A C   1 
ATOM   987  O O   . VAL   A 1 136 ? 8.12037   -5.06049  39.11649  1.000 14.60736 ? 491  VAL   A O   1 
ATOM   988  C CB  . VAL   A 1 136 ? 8.01339   -8.00768  40.45688  1.000 15.05409 ? 491  VAL   A CB  1 
ATOM   989  C CG1 . VAL   A 1 136 ? 7.33355   -8.96713  41.42966  1.000 19.84052 ? 491  VAL   A CG1 1 
ATOM   990  C CG2 . VAL   A 1 136 ? 7.43195   -8.25201  39.06941  1.000 16.42038 ? 491  VAL   A CG2 1 
ATOM   991  N N   . HIS   A 1 137 ? 9.78147   -5.16825  40.64305  1.000 13.10944 ? 492  HIS   A N   1 
ATOM   992  C CA  . HIS   A 1 137 ? 10.53369  -4.10999  39.97464  1.000 12.11475 ? 492  HIS   A CA  1 
ATOM   993  C C   . HIS   A 1 137 ? 11.28677  -4.64318  38.77697  1.000 14.10709 ? 492  HIS   A C   1 
ATOM   994  O O   . HIS   A 1 137 ? 11.22463  -4.06809  37.67272  1.000 12.60432 ? 492  HIS   A O   1 
ATOM   995  C CB  . HIS   A 1 137 ? 11.49483  -3.46493  40.96717  1.000 11.78300 ? 492  HIS   A CB  1 
ATOM   996  C CG  . HIS   A 1 137 ? 12.21986  -2.28367  40.40433  1.000 11.15469 ? 492  HIS   A CG  1 
ATOM   997  N ND1 . HIS   A 1 137 ? 13.31969  -2.39250  39.57852  1.000 12.28318 ? 492  HIS   A ND1 1 
ATOM   998  C CD2 . HIS   A 1 137 ? 11.99891  -0.96042  40.57824  1.000 14.60879 ? 492  HIS   A CD2 1 
ATOM   999  C CE1 . HIS   A 1 137 ? 13.72435  -1.17900  39.24560  1.000 14.27815 ? 492  HIS   A CE1 1 
ATOM   1000 N NE2 . HIS   A 1 137 ? 12.94708  -0.28842  39.84650  1.000 14.41268 ? 492  HIS   A NE2 1 
ATOM   1001 N N   . ARG   A 1 138 ? 12.03483  -5.72826  38.98347  1.000 12.86633 ? 493  ARG   A N   1 
ATOM   1002 C CA  . ARG   A 1 138 ? 12.75405  -6.45483  37.95744  1.000 11.05893 ? 493  ARG   A CA  1 
ATOM   1003 C C   . ARG   A 1 138 ? 13.96393  -5.73397  37.37554  1.000 12.15402 ? 493  ARG   A C   1 
ATOM   1004 O O   . ARG   A 1 138 ? 14.58289  -6.21967  36.41200  1.000 14.11780 ? 493  ARG   A O   1 
ATOM   1005 C CB  . ARG   A 1 138 ? 11.84004  -6.88143  36.79920  1.000 16.43109 ? 493  ARG   A CB  1 
ATOM   1006 C CG  . ARG   A 1 138 ? 10.76087  -7.87338  37.26487  1.000 14.58272 ? 493  ARG   A CG  1 
ATOM   1007 C CD  . ARG   A 1 138 ? 9.87157   -8.34651  36.10903  1.000 16.22913 ? 493  ARG   A CD  1 
ATOM   1008 N NE  . ARG   A 1 138 ? 10.64156  -9.20760  35.24238  1.000 19.72481 ? 493  ARG   A NE  1 
ATOM   1009 C CZ  . ARG   A 1 138 ? 10.78667  -9.01391  33.93873  1.000 21.65452 ? 493  ARG   A CZ  1 
ATOM   1010 N NH1 . ARG   A 1 138 ? 10.34967  -7.91578  33.34284  1.000 22.35640 ? 493  ARG   A NH1 1 
ATOM   1011 N NH2 . ARG   A 1 138 ? 11.39102  -9.94378  33.21492  1.000 22.31259 ? 493  ARG   A NH2 1 
ATOM   1012 N N   . ASP   A 1 139 ? 14.37680  -4.61592  37.94354  1.000 12.68072 ? 494  ASP   A N   1 
ATOM   1013 C CA  . ASP   A 1 139 ? 15.66733  -4.02543  37.53862  1.000 15.26945 ? 494  ASP   A CA  1 
ATOM   1014 C C   . ASP   A 1 139 ? 16.25335  -3.26600  38.72643  1.000 12.30787 ? 494  ASP   A C   1 
ATOM   1015 O O   . ASP   A 1 139 ? 16.70312  -2.13074  38.60879  1.000 12.45275 ? 494  ASP   A O   1 
ATOM   1016 C CB  . ASP   A 1 139 ? 15.47624  -3.08382  36.34298  1.000 16.07167 ? 494  ASP   A CB  1 
ATOM   1017 C CG  . ASP   A 1 139 ? 16.74472  -2.80617  35.59531  1.000 20.17373 ? 494  ASP   A CG  1 
ATOM   1018 O OD1 . ASP   A 1 139 ? 17.77608  -3.40835  35.93105  1.000 20.83033 ? 494  ASP   A OD1 1 
ATOM   1019 O OD2 . ASP   A 1 139 ? 16.68408  -1.93283  34.67310  1.000 21.07369 ? 494  ASP   A OD2 1 
ATOM   1020 N N   . LEU   A 1 140 ? 16.26312  -3.88451  39.92050  1.000 12.61325 ? 495  LEU   A N   1 
ATOM   1021 C CA  . LEU   A 1 140 ? 16.68903  -3.18691  41.14599  1.000 12.69287 ? 495  LEU   A CA  1 
ATOM   1022 C C   . LEU   A 1 140 ? 18.19673  -3.24259  41.29022  1.000 13.93706 ? 495  LEU   A C   1 
ATOM   1023 O O   . LEU   A 1 140 ? 18.76196  -4.23862  41.72068  1.000 19.71270 ? 495  LEU   A O   1 
ATOM   1024 C CB  . LEU   A 1 140 ? 15.98144  -3.79492  42.35129  1.000 12.29309 ? 495  LEU   A CB  1 
ATOM   1025 C CG  . LEU   A 1 140 ? 16.24080  -3.07869  43.65432  1.000 13.98846 ? 495  LEU   A CG  1 
ATOM   1026 C CD1 . LEU   A 1 140 ? 15.81203  -1.61005  43.64910  1.000 13.42800 ? 495  LEU   A CD1 1 
ATOM   1027 C CD2 . LEU   A 1 140 ? 15.54089  -3.87034  44.77545  1.000 15.15423 ? 495  LEU   A CD2 1 
ATOM   1028 N N   . ALA   A 1 141 ? 18.82593  -2.14057  40.96996  1.000 11.32373 ? 496  ALA   A N   1 
ATOM   1029 C CA  . ALA   A 1 141 ? 20.27768  -2.01535  40.86625  1.000 10.38459 ? 496  ALA   A CA  1 
ATOM   1030 C C   . ALA   A 1 141 ? 20.63920  -0.61503  41.29684  1.000 12.90386 ? 496  ALA   A C   1 
ATOM   1031 O O   . ALA   A 1 141 ? 19.79297  0.28572   41.30431  1.000 13.49046 ? 496  ALA   A O   1 
ATOM   1032 C CB  . ALA   A 1 141 ? 20.73977  -2.24916  39.42351  1.000 11.61455 ? 496  ALA   A CB  1 
ATOM   1033 N N   . ALA   A 1 142 ? 21.88905  -0.41995  41.73974  1.000 12.16298 ? 497  ALA   A N   1 
ATOM   1034 C CA  . ALA   A 1 142 ? 22.22681  0.90462   42.25651  1.000 11.96990 ? 497  ALA   A CA  1 
ATOM   1035 C C   . ALA   A 1 142 ? 22.10008  2.01172   41.22693  1.000 12.51450 ? 497  ALA   A C   1 
ATOM   1036 O O   . ALA   A 1 142 ? 21.88391  3.17570   41.61719  1.000 13.44274 ? 497  ALA   A O   1 
ATOM   1037 C CB  . ALA   A 1 142 ? 23.65149  0.88706   42.84036  1.000 12.25372 ? 497  ALA   A CB  1 
ATOM   1038 N N   . ARG   A 1 143 ? 22.25390  1.71030   39.92074  1.000 11.13946 ? 498  ARG   A N   1 
ATOM   1039 C CA  . ARG   A 1 143 ? 22.05500  2.74923   38.91507  1.000 14.03258 ? 498  ARG   A CA  1 
ATOM   1040 C C   . ARG   A 1 143 ? 20.62307  3.23062   38.86691  1.000 12.46703 ? 498  ARG   A C   1 
ATOM   1041 O O   . ARG   A 1 143 ? 20.36796  4.31179   38.32142  1.000 13.94444 ? 498  ARG   A O   1 
ATOM   1042 C CB  . ARG   A 1 143 ? 22.44637  2.23003   37.52702  1.000 16.15965 ? 498  ARG   A CB  1 
ATOM   1043 C CG  . ARG   A 1 143 ? 21.53846  1.08384   37.04666  1.000 17.34813 ? 498  ARG   A CG  1 
ATOM   1044 C CD  . ARG   A 1 143 ? 21.94477  0.51788   35.62976  1.000 24.25982 ? 498  ARG   A CD  1 
ATOM   1045 N NE  . ARG   A 1 143 ? 21.17770  -0.69175  35.34267  1.000 25.88320 ? 498  ARG   A NE  1 
ATOM   1046 C CZ  . ARG   A 1 143 ? 21.51119  -1.89409  35.79967  1.000 27.54280 ? 498  ARG   A CZ  1 
ATOM   1047 N NH1 . ARG   A 1 143 ? 22.63563  -2.09270  36.48467  1.000 28.26905 ? 498  ARG   A NH1 1 
ATOM   1048 N NH2 . ARG   A 1 143 ? 20.70984  -2.92936  35.55895  1.000 29.20070 ? 498  ARG   A NH2 1 
ATOM   1049 N N   . ASN   A 1 144 ? 19.69057  2.44594   39.41456  1.000 11.54308 ? 499  ASN   A N   1 
ATOM   1050 C CA  . ASN   A 1 144 ? 18.26404  2.75700   39.38906  1.000 13.26477 ? 499  ASN   A CA  1 
ATOM   1051 C C   . ASN   A 1 144 ? 17.79683  3.27984   40.72370  1.000 15.20958 ? 499  ASN   A C   1 
ATOM   1052 O O   . ASN   A 1 144 ? 16.60573  3.30187   40.99559  1.000 18.77465 ? 499  ASN   A O   1 
ATOM   1053 C CB  . ASN   A 1 144 ? 17.50776  1.53498   38.94158  1.000 12.84574 ? 499  ASN   A CB  1 
ATOM   1054 C CG  . ASN   A 1 144 ? 17.75522  1.23729   37.47432  1.000 13.27643 ? 499  ASN   A CG  1 
ATOM   1055 O OD1 . ASN   A 1 144 ? 18.15284  2.12897   36.69089  1.000 13.71079 ? 499  ASN   A OD1 1 
ATOM   1056 N ND2 . ASN   A 1 144 ? 17.56952  -0.00396  37.08583  1.000 15.22429 ? 499  ASN   A ND2 1 
ATOM   1057 N N   . VAL   A 1 145 ? 18.70596  3.67528   41.58130  1.000 12.57430 ? 500  VAL   A N   1 
ATOM   1058 C CA  . VAL   A 1 145 ? 18.38141  4.44174   42.79143  1.000 13.32641 ? 500  VAL   A CA  1 
ATOM   1059 C C   . VAL   A 1 145 ? 18.89089  5.85345   42.54820  1.000 12.00499 ? 500  VAL   A C   1 
ATOM   1060 O O   . VAL   A 1 145 ? 20.03614  6.02418   42.10009  1.000 14.08207 ? 500  VAL   A O   1 
ATOM   1061 C CB  . VAL   A 1 145 ? 19.06209  3.85753   44.03451  1.000 12.49579 ? 500  VAL   A CB  1 
ATOM   1062 C CG1 . VAL   A 1 145 ? 18.75055  4.73101   45.29211  1.000 14.47753 ? 500  VAL   A CG1 1 
ATOM   1063 C CG2 . VAL   A 1 145 ? 18.50948  2.45200   44.28292  1.000 16.41474 ? 500  VAL   A CG2 1 
ATOM   1064 N N   . LEU   A 1 146 ? 18.05065  6.84842   42.76409  1.000 11.47457 ? 501  LEU   A N   1 
ATOM   1065 C CA  . LEU   A 1 146 ? 18.37577  8.23005   42.44077  1.000 11.61200 ? 501  LEU   A CA  1 
ATOM   1066 C C   . LEU   A 1 146 ? 18.41196  9.02546   43.73238  1.000 12.58867 ? 501  LEU   A C   1 
ATOM   1067 O O   . LEU   A 1 146 ? 17.58266  8.81144   44.60593  1.000 14.67098 ? 501  LEU   A O   1 
ATOM   1068 C CB  . LEU   A 1 146 ? 17.33693  8.84212   41.51745  1.000 15.96666 ? 501  LEU   A CB  1 
ATOM   1069 C CG  . LEU   A 1 146 ? 17.23279  8.11596   40.17568  1.000 19.73760 ? 501  LEU   A CG  1 
ATOM   1070 C CD1 . LEU   A 1 146 ? 16.22559  8.87408   39.35229  1.000 19.97354 ? 501  LEU   A CD1 1 
ATOM   1071 C CD2 . LEU   A 1 146 ? 18.55913  7.98896   39.42490  1.000 27.46831 ? 501  LEU   A CD2 1 
ATOM   1072 N N   . LEU   A 1 147 ? 19.35913  9.94224   43.86852  1.000 12.60741 ? 502  LEU   A N   1 
ATOM   1073 C CA  . LEU   A 1 147 ? 19.44544  10.71192  45.11290  1.000 12.36921 ? 502  LEU   A CA  1 
ATOM   1074 C C   . LEU   A 1 147 ? 18.77052  12.08026  44.99792  1.000 12.88111 ? 502  LEU   A C   1 
ATOM   1075 O O   . LEU   A 1 147 ? 19.06100  12.86585  44.07360  1.000 14.11037 ? 502  LEU   A O   1 
ATOM   1076 C CB  . LEU   A 1 147 ? 20.90830  10.89477  45.51401  1.000 14.85309 ? 502  LEU   A CB  1 
ATOM   1077 C CG  . LEU   A 1 147 ? 21.62945  9.58637   45.84624  1.000 13.59928 ? 502  LEU   A CG  1 
ATOM   1078 C CD1 . LEU   A 1 147 ? 23.08851  9.89152   46.21320  1.000 19.41830 ? 502  LEU   A CD1 1 
ATOM   1079 C CD2 . LEU   A 1 147 ? 20.97286  9.00083   47.05106  1.000 17.05208 ? 502  LEU   A CD2 1 
ATOM   1080 N N   . VAL   A 1 148 ? 17.88421  12.34699  45.95195  1.000 12.03746 ? 503  VAL   A N   1 
ATOM   1081 C CA  . VAL   A 1 148 ? 17.28733  13.67817  46.10512  1.000 13.93814 ? 503  VAL   A CA  1 
ATOM   1082 C C   . VAL   A 1 148 ? 18.26436  14.57325  46.85608  1.000 16.30816 ? 503  VAL   A C   1 
ATOM   1083 O O   . VAL   A 1 148 ? 18.46243  15.74267  46.50765  1.000 15.48555 ? 503  VAL   A O   1 
ATOM   1084 C CB  . VAL   A 1 148 ? 15.96987  13.52630  46.86932  1.000 12.95638 ? 503  VAL   A CB  1 
ATOM   1085 C CG1 . VAL   A 1 148 ? 15.32020  14.92453  47.14555  1.000 14.87320 ? 503  VAL   A CG1 1 
ATOM   1086 C CG2 . VAL   A 1 148 ? 14.99637  12.62497  46.11809  1.000 19.54698 ? 503  VAL   A CG2 1 
ATOM   1087 N N   . THR   A 1 149 ? 18.84438  14.03892  47.92795  1.000 14.66980 ? 504  THR   A N   1 
ATOM   1088 C CA  . THR   A 1 149 ? 19.94029  14.66724  48.64325  1.000 12.83202 ? 504  THR   A CA  1 
ATOM   1089 C C   . THR   A 1 149 ? 20.91705  13.54874  49.00285  1.000 13.67609 ? 504  THR   A C   1 
ATOM   1090 O O   . THR   A 1 149 ? 20.63743  12.35428  48.78800  1.000 14.29809 ? 504  THR   A O   1 
ATOM   1091 C CB  . THR   A 1 149 ? 19.48966  15.37761  49.93138  1.000 15.55044 ? 504  THR   A CB  1 
ATOM   1092 O OG1 . THR   A 1 149 ? 19.18375  14.39287  50.93377  1.000 15.34468 ? 504  THR   A OG1 1 
ATOM   1093 C CG2 . THR   A 1 149 ? 18.25516  16.26977  49.68418  1.000 18.08473 ? 504  THR   A CG2 1 
ATOM   1094 N N   . GLN   A 1 150 ? 22.02288  13.90333  49.65385  1.000 15.16659 ? 505  GLN   A N   1 
ATOM   1095 C CA  . GLN   A 1 150 ? 22.95166  12.85861  50.08870  1.000 15.18610 ? 505  GLN   A CA  1 
ATOM   1096 C C   . GLN   A 1 150 ? 22.32943  11.92525  51.13700  1.000 16.48470 ? 505  GLN   A C   1 
ATOM   1097 O O   . GLN   A 1 150 ? 22.87969  10.84496  51.40947  1.000 15.99959 ? 505  GLN   A O   1 
ATOM   1098 C CB  . GLN   A 1 150 ? 24.21227  13.54691  50.64419  1.000 21.10575 ? 505  GLN   A CB  1 
ATOM   1099 C CG  . GLN   A 1 150 ? 25.34527  12.63864  50.93067  1.000 23.21827 ? 505  GLN   A CG  1 
ATOM   1100 C CD  . GLN   A 1 150 ? 26.47671  13.36108  51.65353  1.000 29.10462 ? 505  GLN   A CD  1 
ATOM   1101 O OE1 . GLN   A 1 150 ? 26.75278  14.56091  51.40067  1.000 29.56548 ? 505  GLN   A OE1 1 
ATOM   1102 N NE2 . GLN   A 1 150 ? 27.11051  12.66154  52.58588  1.000 24.17698 ? 505  GLN   A NE2 1 
ATOM   1103 N N   . HIS   A 1 151 ? 21.18711  12.29318  51.70863  1.000 15.20397 ? 506  HIS   A N   1 
ATOM   1104 C CA  . HIS   A 1 151 ? 20.50559  11.53395  52.75096  1.000 14.71452 ? 506  HIS   A CA  1 
ATOM   1105 C C   . HIS   A 1 151 ? 19.09000  11.12530  52.37522  1.000 15.90867 ? 506  HIS   A C   1 
ATOM   1106 O O   . HIS   A 1 151 ? 18.28990  10.80097  53.25957  1.000 15.19044 ? 506  HIS   A O   1 
ATOM   1107 C CB  . HIS   A 1 151 ? 20.47445  12.34977  54.05277  1.000 17.15111 ? 506  HIS   A CB  1 
ATOM   1108 C CG  . HIS   A 1 151 ? 21.83323  12.67811  54.55566  1.000 17.34100 ? 506  HIS   A CG  1 
ATOM   1109 N ND1 . HIS   A 1 151 ? 22.61757  11.74120  55.20820  1.000 19.25447 ? 506  HIS   A ND1 1 
ATOM   1110 C CD2 . HIS   A 1 151 ? 22.59556  13.78928  54.40916  1.000 18.10361 ? 506  HIS   A CD2 1 
ATOM   1111 C CE1 . HIS   A 1 151 ? 23.78345  12.29573  55.49082  1.000 20.49838 ? 506  HIS   A CE1 1 
ATOM   1112 N NE2 . HIS   A 1 151 ? 23.80132  13.53382  55.01551  1.000 20.93584 ? 506  HIS   A NE2 1 
ATOM   1113 N N   . TYR   A 1 152 ? 18.76844  11.08100  51.06216  1.000 14.34082 ? 507  TYR   A N   1 
ATOM   1114 C CA  . TYR   A 1 152 ? 17.41659  10.75674  50.63985  1.000 14.36866 ? 507  TYR   A CA  1 
ATOM   1115 C C   . TYR   A 1 152 ? 17.49459  10.10783  49.25929  1.000 12.96582 ? 507  TYR   A C   1 
ATOM   1116 O O   . TYR   A 1 152 ? 17.77363  10.79677  48.26355  1.000 13.71477 ? 507  TYR   A O   1 
ATOM   1117 C CB  . TYR   A 1 152 ? 16.58897  12.03046  50.63608  1.000 14.36013 ? 507  TYR   A CB  1 
ATOM   1118 C CG  . TYR   A 1 152 ? 15.11172  11.88930  50.29171  1.000 16.77767 ? 507  TYR   A CG  1 
ATOM   1119 C CD1 . TYR   A 1 152 ? 14.52655  10.65499  50.09053  1.000 13.74941 ? 507  TYR   A CD1 1 
ATOM   1120 C CD2 . TYR   A 1 152 ? 14.31128  13.01746  50.21811  1.000 17.42003 ? 507  TYR   A CD2 1 
ATOM   1121 C CE1 . TYR   A 1 152 ? 13.17323  10.51660  49.80430  1.000 15.38515 ? 507  TYR   A CE1 1 
ATOM   1122 C CE2 . TYR   A 1 152 ? 12.95516  12.89854  49.88319  1.000 17.44504 ? 507  TYR   A CE2 1 
ATOM   1123 C CZ  . TYR   A 1 152 ? 12.40843  11.65939  49.68748  1.000 15.97066 ? 507  TYR   A CZ  1 
ATOM   1124 O OH  . TYR   A 1 152 ? 11.08218  11.55562  49.39227  1.000 18.49978 ? 507  TYR   A OH  1 
ATOM   1125 N N   . ALA   A 1 153 ? 17.26046  8.78564   49.22147  1.000 13.27724 ? 508  ALA   A N   1 
ATOM   1126 C CA  . ALA   A 1 153 ? 17.23251  7.96902   48.01285  1.000 12.22069 ? 508  ALA   A CA  1 
ATOM   1127 C C   . ALA   A 1 153 ? 15.80237  7.62095   47.60936  1.000 13.68238 ? 508  ALA   A C   1 
ATOM   1128 O O   . ALA   A 1 153 ? 14.91318  7.47025   48.45561  1.000 13.52637 ? 508  ALA   A O   1 
ATOM   1129 C CB  . ALA   A 1 153 ? 17.96871  6.66055   48.25310  1.000 12.96526 ? 508  ALA   A CB  1 
ATOM   1130 N N   . LYS   A 1 154 ? 15.59543  7.50395   46.28081  1.000 14.39092 ? 509  LYS   A N   1 
ATOM   1131 C CA  . LYS   A 1 154 ? 14.34493  7.09250   45.67116  1.000 11.81012 ? 509  LYS   A CA  1 
ATOM   1132 C C   . LYS   A 1 154 ? 14.63956  6.04967   44.61159  1.000 14.52603 ? 509  LYS   A C   1 
ATOM   1133 O O   . LYS   A 1 154 ? 15.60145  6.17794   43.85724  1.000 16.05411 ? 509  LYS   A O   1 
ATOM   1134 C CB  . LYS   A 1 154 ? 13.69174  8.26892   44.96254  1.000 12.51025 ? 509  LYS   A CB  1 
ATOM   1135 C CG  . LYS   A 1 154 ? 12.97938  9.20035   45.95019  1.000 13.87670 ? 509  LYS   A CG  1 
ATOM   1136 C CD  . LYS   A 1 154 ? 12.37549  10.38956  45.17863  1.000 18.55213 ? 509  LYS   A CD  1 
ATOM   1137 C CE  . LYS   A 1 154 ? 11.56545  11.27920  46.10911  1.000 17.19823 ? 509  LYS   A CE  1 
ATOM   1138 N NZ  . LYS   A 1 154 ? 10.15038  10.70226  46.10421  1.000 19.66130 ? 509  LYS   A NZ  1 
ATOM   1139 N N   . ILE   A 1 155 ? 13.74883  5.11393   44.46760  1.000 11.17063 ? 510  ILE   A N   1 
ATOM   1140 C CA  . ILE   A 1 155 ? 13.84015  4.08651   43.42691  1.000 12.60824 ? 510  ILE   A CA  1 
ATOM   1141 C C   . ILE   A 1 155 ? 13.22647  4.59380   42.13352  1.000 10.82919 ? 510  ILE   A C   1 
ATOM   1142 O O   . ILE   A 1 155 ? 12.13232  5.16456   42.14308  1.000 13.53188 ? 510  ILE   A O   1 
ATOM   1143 C CB  . ILE   A 1 155 ? 13.11994  2.83331   43.90982  1.000 10.76573 ? 510  ILE   A CB  1 
ATOM   1144 C CG1 . ILE   A 1 155 ? 13.72550  2.27076   45.21356  1.000 12.41584 ? 510  ILE   A CG1 1 
ATOM   1145 C CG2 . ILE   A 1 155 ? 13.14160  1.75201   42.76344  1.000 13.36631 ? 510  ILE   A CG2 1 
ATOM   1146 C CD1 . ILE   A 1 155 ? 12.73919  1.42743   45.99695  1.000 13.73205 ? 510  ILE   A CD1 1 
ATOM   1147 N N   . SER   A 1 156 ? 13.93078  4.34214   41.02781  1.000 12.27643 ? 511  SER   A N   1 
ATOM   1148 C CA  . SER   A 1 156 ? 13.48882  4.79907   39.73474  1.000 13.00304 ? 511  SER   A CA  1 
ATOM   1149 C C   . SER   A 1 156 ? 13.40764  3.58824   38.81108  1.000 13.06632 ? 511  SER   A C   1 
ATOM   1150 O O   . SER   A 1 156 ? 13.66558  2.44139   39.19571  1.000 12.69143 ? 511  SER   A O   1 
ATOM   1151 C CB  . SER   A 1 156 ? 14.50617  5.79807   39.14954  1.000 15.78432 ? 511  SER   A CB  1 
ATOM   1152 O OG  . SER   A 1 156 ? 15.76783  5.11155   38.93485  1.000 20.73726 ? 511  SER   A OG  1 
ATOM   1153 N N   . ASP   A 1 157 ? 13.13907  3.88465   37.53198  1.000 12.86941 ? 512  ASP   A N   1 
ATOM   1154 C CA  . ASP   A 1 157 ? 13.37276  2.94240   36.42802  1.000 11.63908 ? 512  ASP   A CA  1 
ATOM   1155 C C   . ASP   A 1 157 ? 12.46409  1.71302   36.48051  1.000 12.66839 ? 512  ASP   A C   1 
ATOM   1156 O O   . ASP   A 1 157 ? 12.89569  0.56598   36.67717  1.000 13.02669 ? 512  ASP   A O   1 
ATOM   1157 C CB  . ASP   A 1 157 ? 14.86055  2.57273   36.32325  1.000 12.39187 ? 512  ASP   A CB  1 
ATOM   1158 C CG  . ASP   A 1 157 ? 15.62053  3.64420   35.58316  1.000 18.30953 ? 512  ASP   A CG  1 
ATOM   1159 O OD1 . ASP   A 1 157 ? 16.03959  4.61500   36.22097  1.000 18.39517 ? 512  ASP   A OD1 1 
ATOM   1160 O OD2 . ASP   A 1 157 ? 15.65721  3.55533   34.32268  1.000 22.26489 ? 512  ASP   A OD2 1 
ATOM   1161 N N   . PHE   A 1 158 ? 11.18644  1.97258   36.18309  1.000 13.68993 ? 513  PHE   A N   1 
ATOM   1162 C CA  . PHE   A 1 158 ? 10.12009  0.98395   36.23522  1.000 12.29540 ? 513  PHE   A CA  1 
ATOM   1163 C C   . PHE   A 1 158 ? 9.83435   0.36638   34.84904  1.000 12.41246 ? 513  PHE   A C   1 
ATOM   1164 O O   . PHE   A 1 158 ? 8.78305   -0.25935  34.66573  1.000 14.63913 ? 513  PHE   A O   1 
ATOM   1165 C CB  . PHE   A 1 158 ? 8.88462   1.61319   36.88993  1.000 12.62157 ? 513  PHE   A CB  1 
ATOM   1166 C CG  . PHE   A 1 158 ? 9.09906   1.85081   38.34724  1.000 12.59663 ? 513  PHE   A CG  1 
ATOM   1167 C CD1 . PHE   A 1 158 ? 9.64590   3.04345   38.80186  1.000 15.63454 ? 513  PHE   A CD1 1 
ATOM   1168 C CD2 . PHE   A 1 158 ? 8.77036   0.85462   39.26964  1.000 15.34050 ? 513  PHE   A CD2 1 
ATOM   1169 C CE1 . PHE   A 1 158 ? 9.86964   3.22160   40.17636  1.000 16.32007 ? 513  PHE   A CE1 1 
ATOM   1170 C CE2 . PHE   A 1 158 ? 9.01792   1.03534   40.58872  1.000 18.58460 ? 513  PHE   A CE2 1 
ATOM   1171 C CZ  . PHE   A 1 158 ? 9.55611   2.21556   41.05394  1.000 15.48141 ? 513  PHE   A CZ  1 
ATOM   1172 N N   . GLY   A 1 159 ? 10.78404  0.47708   33.91842  1.000 14.83497 ? 514  GLY   A N   1 
ATOM   1173 C CA  . GLY   A 1 159 ? 10.52956  -0.03398  32.57723  1.000 13.80500 ? 514  GLY   A CA  1 
ATOM   1174 C C   . GLY   A 1 159 ? 10.36524  -1.54274  32.46102  1.000 18.65487 ? 514  GLY   A C   1 
ATOM   1175 O O   . GLY   A 1 159 ? 9.73078   -2.00791  31.50676  1.000 19.77680 ? 514  GLY   A O   1 
ATOM   1176 N N   . LEU   A 1 160 ? 10.93658  -2.32640  33.37226  1.000 14.15154 ? 515  LEU   A N   1 
ATOM   1177 C CA  . LEU   A 1 160 ? 10.71308  -3.78222  33.38788  1.000 14.58888 ? 515  LEU   A CA  1 
ATOM   1178 C C   . LEU   A 1 160 ? 9.68944   -4.23813  34.43583  1.000 13.69576 ? 515  LEU   A C   1 
ATOM   1179 O O   . LEU   A 1 160 ? 9.44531   -5.44893  34.57765  1.000 14.81564 ? 515  LEU   A O   1 
ATOM   1180 C CB  . LEU   A 1 160 ? 12.03396  -4.53725  33.65924  1.000 14.64799 ? 515  LEU   A CB  1 
ATOM   1181 C CG  . LEU   A 1 160 ? 13.16427  -4.33162  32.65692  1.000 19.06795 ? 515  LEU   A CG  1 
ATOM   1182 C CD1 . LEU   A 1 160 ? 14.44773  -5.12775  32.94283  1.000 21.32263 ? 515  LEU   A CD1 1 
ATOM   1183 C CD2 . LEU   A 1 160 ? 12.62989  -4.63398  31.24246  1.000 27.48705 ? 515  LEU   A CD2 1 
ATOM   1184 N N   . SER   A 1 161 ? 9.09709   -3.30952  35.17824  1.000 13.63315 ? 516  SER   A N   1 
ATOM   1185 C CA  . SER   A 1 161 ? 8.28489   -3.66823  36.30772  1.000 11.53794 ? 516  SER   A CA  1 
ATOM   1186 C C   . SER   A 1 161 ? 6.94284   -4.22926  35.85065  1.000 12.89277 ? 516  SER   A C   1 
ATOM   1187 O O   . SER   A 1 161 ? 6.41035   -3.86906  34.78548  1.000 16.20194 ? 516  SER   A O   1 
ATOM   1188 C CB  . SER   A 1 161 ? 8.06862   -2.44867  37.18484  1.000 16.36756 ? 516  SER   A CB  1 
ATOM   1189 O OG  . SER   A 1 161 ? 7.36200   -1.43275  36.51428  0.485 16.52560 ? 516  SER   A OG  1 
ATOM   1190 N N   . LYS   A 1 162 ? 6.38891   -5.10152  36.68513  1.000 13.91153 ? 517  LYS   A N   1 
ATOM   1191 C CA  . LYS   A 1 162 ? 5.10160   -5.72354  36.37221  1.000 14.50422 ? 517  LYS   A CA  1 
ATOM   1192 C C   . LYS   A 1 162 ? 4.15756   -5.64020  37.56442  1.000 13.55313 ? 517  LYS   A C   1 
ATOM   1193 O O   . LYS   A 1 162 ? 4.56384   -5.83272  38.71840  1.000 16.23659 ? 517  LYS   A O   1 
ATOM   1194 C CB  . LYS   A 1 162 ? 5.30183   -7.17461  35.97913  1.000 15.18342 ? 517  LYS   A CB  1 
ATOM   1195 C CG  . LYS   A 1 162 ? 6.19717   -7.38272  34.78667  1.000 16.32225 ? 517  LYS   A CG  1 
ATOM   1196 C CD  . LYS   A 1 162 ? 5.49198   -6.85113  33.56369  1.000 19.97712 ? 517  LYS   A CD  1 
ATOM   1197 C CE  . LYS   A 1 162 ? 6.35631   -7.09646  32.37482  1.000 24.33945 ? 517  LYS   A CE  1 
ATOM   1198 N NZ  . LYS   A 1 162 ? 5.60471   -6.85995  31.10703  1.000 31.54231 ? 517  LYS   A NZ  1 
ATOM   1199 N N   . ALA   A 1 163 ? 2.86174   -5.45275  37.28129  1.000 15.20233 ? 518  ALA   A N   1 
ATOM   1200 C CA  . ALA   A 1 163 ? 1.83962   -5.61817  38.30633  1.000 15.04117 ? 518  ALA   A CA  1 
ATOM   1201 C C   . ALA   A 1 163 ? 1.46997   -7.09282  38.38741  1.000 15.06798 ? 518  ALA   A C   1 
ATOM   1202 O O   . ALA   A 1 163 ? 1.08681   -7.69628  37.36941  1.000 18.15662 ? 518  ALA   A O   1 
ATOM   1203 C CB  . ALA   A 1 163 ? 0.59323   -4.78642  37.97001  1.000 16.19635 ? 518  ALA   A CB  1 
ATOM   1204 N N   . LEU   A 1 164 ? 1.60866   -7.69544  39.55066  1.000 15.13944 ? 519  LEU   A N   1 
ATOM   1205 C CA  . LEU   A 1 164 ? 1.33537   -9.12477  39.61362  1.000 16.90602 ? 519  LEU   A CA  1 
ATOM   1206 C C   . LEU   A 1 164 ? -0.15499  -9.37905  39.43289  1.000 16.26361 ? 519  LEU   A C   1 
ATOM   1207 O O   . LEU   A 1 164 ? -0.98876  -8.59831  39.93245  1.000 17.05001 ? 519  LEU   A O   1 
ATOM   1208 C CB  . LEU   A 1 164 ? 1.78381   -9.72269  40.93739  1.000 17.18635 ? 519  LEU   A CB  1 
ATOM   1209 C CG  . LEU   A 1 164 ? 3.29494   -9.66988  41.15334  1.000 15.99961 ? 519  LEU   A CG  1 
ATOM   1210 C CD1 . LEU   A 1 164 ? 3.55684   -10.11120 42.61440  1.000 19.88985 ? 519  LEU   A CD1 1 
ATOM   1211 C CD2 . LEU   A 1 164 ? 3.96154   -10.58831 40.22335  1.000 17.61999 ? 519  LEU   A CD2 1 
ATOM   1212 N N   . ARG   A 1 165 ? -0.47211  -10.49301 38.76689  1.000 14.73154 ? 520  ARG   A N   1 
ATOM   1213 C CA  . ARG   A 1 165 ? -1.86546  -10.97350 38.72342  1.000 15.93390 ? 520  ARG   A CA  1 
ATOM   1214 C C   . ARG   A 1 165 ? -2.42393  -11.24075 40.10526  1.000 18.02924 ? 520  ARG   A C   1 
ATOM   1215 O O   . ARG   A 1 165 ? -1.72721  -11.65421 41.02929  1.000 17.75434 ? 520  ARG   A O   1 
ATOM   1216 C CB  . ARG   A 1 165 ? -1.93818  -12.26376 37.90562  1.000 17.74333 ? 520  ARG   A CB  1 
ATOM   1217 C CG  . ARG   A 1 165 ? -1.76176  -12.03988 36.46058  1.000 21.86761 ? 520  ARG   A CG  1 
ATOM   1218 C CD  . ARG   A 1 165 ? -1.65790  -13.38772 35.69748  1.000 23.55842 ? 520  ARG   A CD  1 
ATOM   1219 N NE  . ARG   A 1 165 ? -2.69270  -14.34511 36.10285  1.000 24.17632 ? 520  ARG   A NE  1 
ATOM   1220 C CZ  . ARG   A 1 165 ? -3.20043  -15.25497 35.28747  1.000 28.96680 ? 520  ARG   A CZ  1 
ATOM   1221 N NH1 . ARG   A 1 165 ? -2.83438  -15.31489 34.01682  1.000 32.59768 ? 520  ARG   A NH1 1 
ATOM   1222 N NH2 . ARG   A 1 165 ? -4.08583  -16.13141 35.76068  1.000 30.24892 ? 520  ARG   A NH2 1 
ATOM   1223 N N   . ALA   A 1 166 ? -3.74610  -11.08825 40.23724  1.000 13.77948 ? 521  ALA   A N   1 
ATOM   1224 C CA  . ALA   A 1 166 ? -4.34588  -11.23250 41.55228  1.000 13.48156 ? 521  ALA   A CA  1 
ATOM   1225 C C   . ALA   A 1 166 ? -4.21610  -12.64998 42.09364  1.000 17.30861 ? 521  ALA   A C   1 
ATOM   1226 O O   . ALA   A 1 166 ? -4.31795  -12.83552 43.31929  1.000 18.05774 ? 521  ALA   A O   1 
ATOM   1227 C CB  . ALA   A 1 166 ? -5.83282  -10.83708 41.46452  1.000 15.44203 ? 521  ALA   A CB  1 
ATOM   1228 N N   . ASP   A 1 167 ? -4.02972  -13.63625 41.20802  1.000 17.81109 ? 522  ASP   A N   1 
ATOM   1229 C CA  . ASP   A 1 167 ? -4.00018  -15.03707 41.61034  1.000 17.14447 ? 522  ASP   A CA  1 
ATOM   1230 C C   . ASP   A 1 167 ? -2.58323  -15.61430 41.63275  1.000 24.15738 ? 522  ASP   A C   1 
ATOM   1231 O O   . ASP   A 1 167 ? -2.43639  -16.82573 41.79227  1.000 24.27438 ? 522  ASP   A O   1 
ATOM   1232 C CB  . ASP   A 1 167 ? -4.86808  -15.89270 40.65782  1.000 19.33924 ? 522  ASP   A CB  1 
ATOM   1233 C CG  . ASP   A 1 167 ? -4.40205  -15.85452 39.18579  1.000 23.47223 ? 522  ASP   A CG  1 
ATOM   1234 O OD1 . ASP   A 1 167 ? -3.57470  -14.99559 38.80788  1.000 21.97605 ? 522  ASP   A OD1 1 
ATOM   1235 O OD2 . ASP   A 1 167 ? -4.87334  -16.68345 38.34471  1.000 26.47495 ? 522  ASP   A OD2 1 
ATOM   1236 N N   . GLU   A 1 168 ? -1.54763  -14.79243 41.45067  1.000 19.83918 ? 523  GLU   A N   1 
ATOM   1237 C CA  . GLU   A 1 168 ? -0.18689  -15.31486 41.33895  1.000 20.84267 ? 523  GLU   A CA  1 
ATOM   1238 C C   . GLU   A 1 168 ? 0.75904   -14.43828 42.11999  1.000 18.17547 ? 523  GLU   A C   1 
ATOM   1239 O O   . GLU   A 1 168 ? 0.58941   -13.22730 42.21740  1.000 19.65254 ? 523  GLU   A O   1 
ATOM   1240 C CB  . GLU   A 1 168 ? 0.30844   -15.36144 39.90387  1.000 24.54646 ? 523  GLU   A CB  1 
ATOM   1241 C CG  . GLU   A 1 168 ? -0.36075  -16.40081 39.05739  1.000 25.80385 ? 523  GLU   A CG  1 
ATOM   1242 C CD  . GLU   A 1 168 ? 0.12907   -16.37387 37.61634  1.000 50.21291 ? 523  GLU   A CD  1 
ATOM   1243 O OE1 . GLU   A 1 168 ? 1.11317   -15.64173 37.31425  1.000 47.68328 ? 523  GLU   A OE1 1 
ATOM   1244 O OE2 . GLU   A 1 168 ? -0.48626  -17.08320 36.78334  1.000 62.55725 ? 523  GLU   A OE2 1 
ATOM   1245 N N   . ASN   A 1 169 ? 1.80818   -15.04574 42.65955  1.000 19.94024 ? 524  ASN   A N   1 
ATOM   1246 C CA  . ASN   A 1 169 ? 2.73909   -14.21720 43.38913  1.000 23.31355 ? 524  ASN   A CA  1 
ATOM   1247 C C   . ASN   A 1 169 ? 4.03480   -14.04417 42.61496  1.000 21.64074 ? 524  ASN   A C   1 
ATOM   1248 O O   . ASN   A 1 169 ? 5.01886   -13.57008 43.16354  1.000 20.76965 ? 524  ASN   A O   1 
ATOM   1249 C CB  . ASN   A 1 169 ? 2.96282   -14.76384 44.80625  1.000 32.32442 ? 524  ASN   A CB  1 
ATOM   1250 C CG  . ASN   A 1 169 ? 3.96610   -15.84009 44.85770  1.000 40.21047 ? 524  ASN   A CG  1 
ATOM   1251 O OD1 . ASN   A 1 169 ? 4.14591   -16.58589 43.89565  1.000 51.07253 ? 524  ASN   A OD1 1 
ATOM   1252 N ND2 . ASN   A 1 169 ? 4.64389   -15.95200 46.00128  1.000 51.21188 ? 524  ASN   A ND2 1 
ATOM   1253 N N   . TYR   A 1 170 ? 4.02979   -14.36711 41.33166  1.000 16.38377 ? 525  TYR   A N   1 
ATOM   1254 C CA  . TYR   A 1 170 ? 5.16297   -14.06974 40.47355  1.000 18.97662 ? 525  TYR   A CA  1 
ATOM   1255 C C   . TYR   A 1 170 ? 4.66773   -13.70791 39.08561  1.000 20.50696 ? 525  TYR   A C   1 
ATOM   1256 O O   . TYR   A 1 170 ? 3.49198   -13.93322 38.73450  1.000 21.87829 ? 525  TYR   A O   1 
ATOM   1257 C CB  . TYR   A 1 170 ? 6.09978   -15.26670 40.36715  1.000 19.69326 ? 525  TYR   A CB  1 
ATOM   1258 C CG  . TYR   A 1 170 ? 5.39343   -16.48283 39.82278  1.000 24.55314 ? 525  TYR   A CG  1 
ATOM   1259 C CD1 . TYR   A 1 170 ? 4.64541   -17.29801 40.65827  1.000 25.92877 ? 525  TYR   A CD1 1 
ATOM   1260 C CD2 . TYR   A 1 170 ? 5.45328   -16.78554 38.46589  1.000 25.15666 ? 525  TYR   A CD2 1 
ATOM   1261 C CE1 . TYR   A 1 170 ? 3.97137   -18.40681 40.14890  1.000 34.78623 ? 525  TYR   A CE1 1 
ATOM   1262 C CE2 . TYR   A 1 170 ? 4.79946   -17.87986 37.96058  1.000 39.91794 ? 525  TYR   A CE2 1 
ATOM   1263 C CZ  . TYR   A 1 170 ? 4.06095   -18.67624 38.80189  1.000 30.85519 ? 525  TYR   A CZ  1 
ATOM   1264 O OH  . TYR   A 1 170 ? 3.42921   -19.77198 38.26037  1.000 47.42352 ? 525  TYR   A OH  1 
ATOM   1265 N N   . TYR   A 1 171 ? 5.56080   -13.06039 38.34153  1.000 16.15696 ? 526  TYR   A N   1 
ATOM   1266 C CA  . TYR   A 1 171 ? 5.41078   -12.79383 36.91858  1.000 14.48029 ? 526  TYR   A CA  1 
ATOM   1267 C C   . TYR   A 1 171 ? 6.27157   -13.79955 36.15518  1.000 18.08333 ? 526  TYR   A C   1 
ATOM   1268 O O   . TYR   A 1 171 ? 7.45854   -13.99212 36.47984  1.000 18.03103 ? 526  TYR   A O   1 
ATOM   1269 C CB  . TYR   A 1 171 ? 5.85085   -11.36059 36.61774  1.000 16.81361 ? 526  TYR   A CB  1 
ATOM   1270 C CG  . TYR   A 1 171 ? 6.02740   -11.09719 35.16872  1.000 15.62546 ? 526  TYR   A CG  1 
ATOM   1271 C CD1 . TYR   A 1 171 ? 4.92601   -10.89166 34.33547  1.000 20.53724 ? 526  TYR   A CD1 1 
ATOM   1272 C CD2 . TYR   A 1 171 ? 7.28911   -11.05129 34.61810  1.000 16.34025 ? 526  TYR   A CD2 1 
ATOM   1273 C CE1 . TYR   A 1 171 ? 5.10855   -10.66466 32.98609  1.000 22.04820 ? 526  TYR   A CE1 1 
ATOM   1274 C CE2 . TYR   A 1 171 ? 7.47620   -10.82144 33.26061  1.000 18.96889 ? 526  TYR   A CE2 1 
ATOM   1275 C CZ  . TYR   A 1 171 ? 6.37779   -10.62961 32.45554  1.000 27.34465 ? 526  TYR   A CZ  1 
ATOM   1276 O OH  . TYR   A 1 171 ? 6.58499   -10.39784 31.11099  1.000 29.34830 ? 526  TYR   A OH  1 
ATOM   1277 N N   . LYS   A 1 172 ? 5.68394   -14.46662 35.15313  1.000 19.27742 ? 527  LYS   A N   1 
ATOM   1278 C CA  . LYS   A 1 172 ? 6.39850   -15.40974 34.31074  1.000 18.71712 ? 527  LYS   A CA  1 
ATOM   1279 C C   . LYS   A 1 172 ? 6.75024   -14.72898 33.00018  1.000 20.20221 ? 527  LYS   A C   1 
ATOM   1280 O O   . LYS   A 1 172 ? 5.84782   -14.30087 32.24772  1.000 25.02853 ? 527  LYS   A O   1 
ATOM   1281 C CB  . LYS   A 1 172 ? 5.54919   -16.65952 34.05094  1.000 25.74576 ? 527  LYS   A CB  1 
ATOM   1282 C CG  . LYS   A 1 172 ? 6.12919   -17.57390 32.97061  1.000 30.65998 ? 527  LYS   A CG  1 
ATOM   1283 C CD  . LYS   A 1 172 ? 7.32359   -18.34475 33.52387  1.000 34.15763 ? 527  LYS   A CD  1 
ATOM   1284 C CE  . LYS   A 1 172 ? 7.65961   -19.60252 32.71874  1.000 33.52563 ? 527  LYS   A CE  1 
ATOM   1285 N NZ  . LYS   A 1 172 ? 8.13754   -19.26791 31.34199  1.000 41.08757 ? 527  LYS   A NZ  1 
ATOM   1286 N N   . ALA   A 1 173 ? 8.03143   -14.61549 32.71392  1.000 20.77796 ? 528  ALA   A N   1 
ATOM   1287 C CA  . ALA   A 1 173 ? 8.45807   -14.02329 31.45919  1.000 20.24795 ? 528  ALA   A CA  1 
ATOM   1288 C C   . ALA   A 1 173 ? 8.41110   -15.05226 30.34583  1.000 28.39491 ? 528  ALA   A C   1 
ATOM   1289 O O   . ALA   A 1 173 ? 8.52200   -16.25886 30.57506  1.000 29.61900 ? 528  ALA   A O   1 
ATOM   1290 C CB  . ALA   A 1 173 ? 9.86928   -13.45493 31.54532  1.000 26.83584 ? 528  ALA   A CB  1 
ATOM   1291 N N   . GLN   A 1 174 ? 8.25622   -14.55125 29.12393  1.000 34.55444 ? 529  GLN   A N   1 
ATOM   1292 C CA  . GLN   A 1 174 ? 8.33866   -15.38974 27.92903  1.000 42.15569 ? 529  GLN   A CA  1 
ATOM   1293 C C   . GLN   A 1 174 ? 9.39353   -14.83938 26.96548  1.000 40.93941 ? 529  GLN   A C   1 
ATOM   1294 O O   . GLN   A 1 174 ? 10.59701  -14.99238 27.18899  1.000 49.88706 ? 529  GLN   A O   1 
ATOM   1295 C CB  . GLN   A 1 174 ? 6.97170   -15.47184 27.24170  1.000 41.70169 ? 529  GLN   A CB  1 
ATOM   1296 C CG  . GLN   A 1 174 ? 5.90205   -16.04430 28.12463  1.000 43.90206 ? 529  GLN   A CG  1 
ATOM   1297 C CD  . GLN   A 1 174 ? 4.51648   -15.72476 27.63482  1.000 57.17500 ? 529  GLN   A CD  1 
ATOM   1298 O OE1 . GLN   A 1 174 ? 4.33183   -14.83742 26.80585  1.000 70.49980 ? 529  GLN   A OE1 1 
ATOM   1299 N NE2 . GLN   A 1 174 ? 3.52601   -16.44716 28.14477  1.000 72.57691 ? 529  GLN   A NE2 1 
ATOM   1300 N N   . LYS   A 1 178 ? 17.39413  -8.16304  26.41628  1.000 44.50675 ? 533  LYS   A N   1 
ATOM   1301 C CA  . LYS   A 1 178 ? 18.57355  -8.26883  27.26900  1.000 44.55828 ? 533  LYS   A CA  1 
ATOM   1302 C C   . LYS   A 1 178 ? 18.15763  -8.07655  28.73250  1.000 38.72713 ? 533  LYS   A C   1 
ATOM   1303 O O   . LYS   A 1 178 ? 17.39046  -7.16605  29.06713  1.000 39.88467 ? 533  LYS   A O   1 
ATOM   1304 C CB  . LYS   A 1 178 ? 19.63948  -7.24488  26.84749  1.000 44.71584 ? 533  LYS   A CB  1 
ATOM   1305 C CG  . LYS   A 1 178 ? 21.00810  -7.43318  27.50594  1.000 48.76990 ? 533  LYS   A CG  1 
ATOM   1306 C CD  . LYS   A 1 178 ? 21.09333  -6.70490  28.84997  1.000 51.46778 ? 533  LYS   A CD  1 
ATOM   1307 C CE  . LYS   A 1 178 ? 20.84609  -5.21680  28.68836  1.000 45.91456 ? 533  LYS   A CE  1 
ATOM   1308 N NZ  . LYS   A 1 178 ? 21.87194  -4.58737  27.80325  1.000 70.19497 ? 533  LYS   A NZ  1 
ATOM   1309 N N   . TRP   A 1 179 ? 18.66247  -8.95226  29.60591  1.000 33.73561 ? 534  TRP   A N   1 
ATOM   1310 C CA  . TRP   A 1 179 ? 18.31700  -8.89173  31.01480  1.000 30.57681 ? 534  TRP   A CA  1 
ATOM   1311 C C   . TRP   A 1 179 ? 19.51966  -8.45951  31.85099  1.000 24.53522 ? 534  TRP   A C   1 
ATOM   1312 O O   . TRP   A 1 179 ? 20.65586  -8.76076  31.49105  1.000 24.91752 ? 534  TRP   A O   1 
ATOM   1313 C CB  . TRP   A 1 179 ? 17.83845  -10.25756 31.50557  1.000 26.54096 ? 534  TRP   A CB  1 
ATOM   1314 C CG  . TRP   A 1 179 ? 16.38028  -10.50752 31.32665  1.000 29.35837 ? 534  TRP   A CG  1 
ATOM   1315 C CD1 . TRP   A 1 179 ? 15.42845  -9.61879  30.88833  1.000 27.46598 ? 534  TRP   A CD1 1 
ATOM   1316 C CD2 . TRP   A 1 179 ? 15.69867  -11.73932 31.59289  1.000 22.08019 ? 534  TRP   A CD2 1 
ATOM   1317 N NE1 . TRP   A 1 179 ? 14.18559  -10.23862 30.86824  1.000 30.77306 ? 534  TRP   A NE1 1 
ATOM   1318 C CE2 . TRP   A 1 179 ? 14.33061  -11.53604 31.29288  1.000 28.26987 ? 534  TRP   A CE2 1 
ATOM   1319 C CE3 . TRP   A 1 179 ? 16.10912  -12.99089 32.05583  1.000 25.23694 ? 534  TRP   A CE3 1 
ATOM   1320 C CZ2 . TRP   A 1 179 ? 13.37568  -12.54077 31.44279  1.000 26.30832 ? 534  TRP   A CZ2 1 
ATOM   1321 C CZ3 . TRP   A 1 179 ? 15.13763  -14.00027 32.20272  1.000 24.07498 ? 534  TRP   A CZ3 1 
ATOM   1322 C CH2 . TRP   A 1 179 ? 13.79256  -13.75196 31.90576  1.000 22.97135 ? 534  TRP   A CH2 1 
ATOM   1323 N N   . PRO   A 1 180 ? 19.30047  -7.79727  32.98949  1.000 21.22663 ? 535  PRO   A N   1 
ATOM   1324 C CA  . PRO   A 1 180 ? 20.42414  -7.47378  33.91220  1.000 22.26973 ? 535  PRO   A CA  1 
ATOM   1325 C C   . PRO   A 1 180 ? 20.78630  -8.67111  34.79228  1.000 19.48476 ? 535  PRO   A C   1 
ATOM   1326 O O   . PRO   A 1 180 ? 20.56432  -8.71438  35.99871  1.000 17.43458 ? 535  PRO   A O   1 
ATOM   1327 C CB  . PRO   A 1 180 ? 19.85987  -6.28970  34.70655  1.000 20.87308 ? 535  PRO   A CB  1 
ATOM   1328 C CG  . PRO   A 1 180 ? 18.37024  -6.54518  34.75283  1.000 23.32627 ? 535  PRO   A CG  1 
ATOM   1329 C CD  . PRO   A 1 180 ? 18.01587  -7.23483  33.45866  1.000 19.01645 ? 535  PRO   A CD  1 
ATOM   1330 N N   . VAL   A 1 181 ? 21.35473  -9.70129  34.16078  1.000 17.84995 ? 536  VAL   A N   1 
ATOM   1331 C CA  . VAL   A 1 181 ? 21.50286  -11.02385 34.76810  1.000 19.91321 ? 536  VAL   A CA  1 
ATOM   1332 C C   . VAL   A 1 181 ? 22.33995  -11.01682 36.05091  1.000 17.06262 ? 536  VAL   A C   1 
ATOM   1333 O O   . VAL   A 1 181 ? 22.08465  -11.81059 36.95882  1.000 15.29200 ? 536  VAL   A O   1 
ATOM   1334 C CB  . VAL   A 1 181 ? 22.09010  -11.97191 33.71470  1.000 27.25325 ? 536  VAL   A CB  1 
ATOM   1335 C CG1 . VAL   A 1 181 ? 22.67481  -13.21947 34.35068  1.000 32.79956 ? 536  VAL   A CG1 1 
ATOM   1336 C CG2 . VAL   A 1 181 ? 20.98695  -12.29178 32.69584  1.000 27.85318 ? 536  VAL   A CG2 1 
ATOM   1337 N N   . LYS   A 1 182 ? 23.32583  -10.12042 36.16274  1.000 15.18240 ? 537  LYS   A N   1 
ATOM   1338 C CA  . LYS   A 1 182 ? 24.11439  -10.06309 37.39905  1.000 14.57853 ? 537  LYS   A CA  1 
ATOM   1339 C C   . LYS   A 1 182 ? 23.27554  -9.63510  38.57968  1.000 13.23407 ? 537  LYS   A C   1 
ATOM   1340 O O   . LYS   A 1 182 ? 23.70692  -9.80217  39.71809  1.000 12.01246 ? 537  LYS   A O   1 
ATOM   1341 C CB  . LYS   A 1 182 ? 25.29606  -9.07468  37.21102  1.000 13.96909 ? 537  LYS   A CB  1 
ATOM   1342 C CG  . LYS   A 1 182 ? 26.44402  -9.72219  36.43448  1.000 16.56879 ? 537  LYS   A CG  1 
ATOM   1343 C CD  . LYS   A 1 182 ? 27.55344  -8.76286  36.09091  1.000 19.85864 ? 537  LYS   A CD  1 
ATOM   1344 C CE  . LYS   A 1 182 ? 28.60397  -9.61991  35.37639  1.000 22.63078 ? 537  LYS   A CE  1 
ATOM   1345 N NZ  . LYS   A 1 182 ? 29.72933  -8.73164  34.94290  1.000 28.67182 ? 537  LYS   A NZ  1 
ATOM   1346 N N   . TRP   A 1 183 ? 22.06105  -9.12979  38.35317  1.000 11.30194 ? 538  TRP   A N   1 
ATOM   1347 C CA  . TRP   A 1 183 ? 21.20972  -8.75477  39.44979  1.000 12.18140 ? 538  TRP   A CA  1 
ATOM   1348 C C   . TRP   A 1 183 ? 20.09415  -9.75570  39.68518  1.000 11.68484 ? 538  TRP   A C   1 
ATOM   1349 O O   . TRP   A 1 183 ? 19.30841  -9.58092  40.65607  1.000 13.84700 ? 538  TRP   A O   1 
ATOM   1350 C CB  . TRP   A 1 183 ? 20.60598  -7.36397  39.23508  1.000 12.08285 ? 538  TRP   A CB  1 
ATOM   1351 C CG  . TRP   A 1 183 ? 21.61623  -6.27235  39.45771  1.000 10.79284 ? 538  TRP   A CG  1 
ATOM   1352 C CD1 . TRP   A 1 183 ? 21.72908  -5.49254  40.59046  1.000 12.46519 ? 538  TRP   A CD1 1 
ATOM   1353 C CD2 . TRP   A 1 183 ? 22.64736  -5.82575  38.53853  1.000 11.34424 ? 538  TRP   A CD2 1 
ATOM   1354 N NE1 . TRP   A 1 183 ? 22.79491  -4.60239  40.41659  1.000 12.73190 ? 538  TRP   A NE1 1 
ATOM   1355 C CE2 . TRP   A 1 183 ? 23.37248  -4.78539  39.20175  1.000 12.35275 ? 538  TRP   A CE2 1 
ATOM   1356 C CE3 . TRP   A 1 183 ? 23.01465  -6.19087  37.24174  1.000 14.39548 ? 538  TRP   A CE3 1 
ATOM   1357 C CZ2 . TRP   A 1 183 ? 24.44181  -4.10071  38.62088  1.000 11.49864 ? 538  TRP   A CZ2 1 
ATOM   1358 C CZ3 . TRP   A 1 183 ? 24.09773  -5.49806  36.64490  1.000 15.92868 ? 538  TRP   A CZ3 1 
ATOM   1359 C CH2 . TRP   A 1 183 ? 24.79812  -4.46147  37.34793  1.000 13.70686 ? 538  TRP   A CH2 1 
ATOM   1360 N N   . TYR   A 1 184 ? 20.02565  -10.80463 38.87830  1.000 13.64496 ? 539  TYR   A N   1 
ATOM   1361 C CA  . TYR   A 1 184 ? 18.85938  -11.68494 38.93230  1.000 13.62521 ? 539  TYR   A CA  1 
ATOM   1362 C C   . TYR   A 1 184 ? 19.07784  -12.94167 39.77146  1.000 16.36049 ? 539  TYR   A C   1 
ATOM   1363 O O   . TYR   A 1 184 ? 20.15508  -13.57843 39.74174  1.000 15.76192 ? 539  TYR   A O   1 
ATOM   1364 C CB  . TYR   A 1 184 ? 18.45914  -12.04043 37.50234  1.000 14.63120 ? 539  TYR   A CB  1 
ATOM   1365 C CG  . TYR   A 1 184 ? 17.58363  -11.02310 36.83957  1.000 15.59497 ? 539  TYR   A CG  1 
ATOM   1366 C CD1 . TYR   A 1 184 ? 17.22164  -9.81190  37.46783  1.000 15.00475 ? 539  TYR   A CD1 1 
ATOM   1367 C CD2 . TYR   A 1 184 ? 17.12566  -11.26849 35.56035  1.000 17.32936 ? 539  TYR   A CD2 1 
ATOM   1368 C CE1 . TYR   A 1 184 ? 16.35402  -8.87747  36.81060  1.000 20.26100 ? 539  TYR   A CE1 1 
ATOM   1369 C CE2 . TYR   A 1 184 ? 16.27314  -10.36386 34.89185  1.000 16.83615 ? 539  TYR   A CE2 1 
ATOM   1370 C CZ  . TYR   A 1 184 ? 15.89609  -9.17701  35.53585  1.000 17.91308 ? 539  TYR   A CZ  1 
ATOM   1371 O OH  . TYR   A 1 184 ? 15.07213  -8.30078  34.87206  1.000 18.48815 ? 539  TYR   A OH  1 
ATOM   1372 N N   . ALA   A 1 185 ? 18.00595  -13.34042 40.44189  1.000 13.10298 ? 540  ALA   A N   1 
ATOM   1373 C CA  . ALA   A 1 185 ? 18.02935  -14.51874 41.29167  1.000 12.55955 ? 540  ALA   A CA  1 
ATOM   1374 C C   . ALA   A 1 185 ? 18.03425  -15.79697 40.43609  1.000 15.09110 ? 540  ALA   A C   1 
ATOM   1375 O O   . ALA   A 1 185 ? 17.67304  -15.77735 39.25816  1.000 15.19720 ? 540  ALA   A O   1 
ATOM   1376 C CB  . ALA   A 1 185 ? 16.81774  -14.53108 42.22357  1.000 13.88836 ? 540  ALA   A CB  1 
ATOM   1377 N N   . PRO   A 1 186 ? 18.40266  -16.93317 41.01522  1.000 14.23922 ? 541  PRO   A N   1 
ATOM   1378 C CA  . PRO   A 1 186 ? 18.50650  -18.13738 40.17401  1.000 14.95707 ? 541  PRO   A CA  1 
ATOM   1379 C C   . PRO   A 1 186 ? 17.17811  -18.55851 39.57940  1.000 18.53022 ? 541  PRO   A C   1 
ATOM   1380 O O   . PRO   A 1 186 ? 17.17889  -19.04312 38.44073  1.000 18.27930 ? 541  PRO   A O   1 
ATOM   1381 C CB  . PRO   A 1 186 ? 19.08462  -19.18144 41.12654  1.000 18.60605 ? 541  PRO   A CB  1 
ATOM   1382 C CG  . PRO   A 1 186 ? 19.86233  -18.35826 42.17488  1.000 18.12385 ? 541  PRO   A CG  1 
ATOM   1383 C CD  . PRO   A 1 186 ? 19.05577  -17.08100 42.33136  1.000 16.11464 ? 541  PRO   A CD  1 
ATOM   1384 N N   . GLU   A 1 187 ? 16.06146  -18.34826 40.28725  1.000 16.61862 ? 542  GLU   A N   1 
ATOM   1385 C CA  . GLU   A 1 187 ? 14.75153  -18.72903 39.73284  1.000 17.68739 ? 542  GLU   A CA  1 
ATOM   1386 C C   . GLU   A 1 187 ? 14.38131  -17.84834 38.54114  1.000 17.30174 ? 542  GLU   A C   1 
ATOM   1387 O O   . GLU   A 1 187 ? 13.64342  -18.28832 37.64877  1.000 16.08185 ? 542  GLU   A O   1 
ATOM   1388 C CB  . GLU   A 1 187 ? 13.66398  -18.68406 40.79403  1.000 17.41374 ? 542  GLU   A CB  1 
ATOM   1389 C CG  . GLU   A 1 187 ? 13.21107  -17.31466 41.28880  1.000 17.82381 ? 542  GLU   A CG  1 
ATOM   1390 C CD  . GLU   A 1 187 ? 14.06576  -16.73722 42.44148  1.000 18.74354 ? 542  GLU   A CD  1 
ATOM   1391 O OE1 . GLU   A 1 187 ? 15.06671  -17.39759 42.90195  1.000 17.31330 ? 542  GLU   A OE1 1 
ATOM   1392 O OE2 . GLU   A 1 187 ? 13.75522  -15.59506 42.89258  1.000 16.51914 ? 542  GLU   A OE2 1 
ATOM   1393 N N   . CYS   A 1 188 ? 14.88221  -16.62251 38.50161  1.000 17.91970 ? 543  CYS   A N   1 
ATOM   1394 C CA  . CYS   A 1 188 ? 14.65901  -15.78454 37.32798  1.000 16.23402 ? 543  CYS   A CA  1 
ATOM   1395 C C   . CYS   A 1 188 ? 15.36323  -16.38979 36.12759  1.000 16.10907 ? 543  CYS   A C   1 
ATOM   1396 O O   . CYS   A 1 188 ? 14.81144  -16.50509 35.01867  1.000 17.75647 ? 543  CYS   A O   1 
ATOM   1397 C CB  . CYS   A 1 188 ? 15.20276  -14.36956 37.60007  1.000 14.61347 ? 543  CYS   A CB  1 
ATOM   1398 S SG  . CYS   A 1 188 ? 14.56913  -13.64828 39.05308  1.000 19.35769 ? 543  CYS   A SG  1 
ATOM   1399 N N   . ILE   A 1 189 ? 16.61012  -16.77959 36.32892  1.000 17.16424 ? 544  ILE   A N   1 
ATOM   1400 C CA  . ILE   A 1 189 ? 17.41668  -17.31290 35.24434  1.000 17.34986 ? 544  ILE   A CA  1 
ATOM   1401 C C   . ILE   A 1 189 ? 16.92126  -18.69491 34.80399  1.000 19.13532 ? 544  ILE   A C   1 
ATOM   1402 O O   . ILE   A 1 189 ? 16.87949  -18.99796 33.59857  1.000 23.57226 ? 544  ILE   A O   1 
ATOM   1403 C CB  . ILE   A 1 189 ? 18.88595  -17.34806 35.70429  1.000 19.65412 ? 544  ILE   A CB  1 
ATOM   1404 C CG1 . ILE   A 1 189 ? 19.39877  -15.93570 36.05321  1.000 21.70975 ? 544  ILE   A CG1 1 
ATOM   1405 C CG2 . ILE   A 1 189 ? 19.76476  -18.07726 34.70690  1.000 28.24815 ? 544  ILE   A CG2 1 
ATOM   1406 C CD1 . ILE   A 1 189 ? 19.32364  -14.94853 34.94372  1.000 27.27790 ? 544  ILE   A CD1 1 
ATOM   1407 N N   . ASN   A 1 190 ? 16.52251  -19.53804 35.75898  1.000 17.93909 ? 545  ASN   A N   1 
ATOM   1408 C CA  . ASN   A 1 190 ? 16.22221  -20.94496 35.47972  1.000 19.13436 ? 545  ASN   A CA  1 
ATOM   1409 C C   . ASN   A 1 190 ? 14.76070  -21.22218 35.19313  1.000 21.01841 ? 545  ASN   A C   1 
ATOM   1410 O O   . ASN   A 1 190 ? 14.45386  -22.23213 34.54561  1.000 22.47170 ? 545  ASN   A O   1 
ATOM   1411 C CB  . ASN   A 1 190 ? 16.62425  -21.81595 36.66967  1.000 20.59656 ? 545  ASN   A CB  1 
ATOM   1412 C CG  . ASN   A 1 190 ? 18.12032  -21.91807 36.82440  1.000 19.58836 ? 545  ASN   A CG  1 
ATOM   1413 O OD1 . ASN   A 1 190 ? 18.86387  -21.83112 35.85800  1.000 25.75101 ? 545  ASN   A OD1 1 
ATOM   1414 N ND2 . ASN   A 1 190 ? 18.56606  -22.04817 38.06565  1.000 26.52501 ? 545  ASN   A ND2 1 
ATOM   1415 N N   . TYR   A 1 191 ? 13.85723  -20.39919 35.66972  1.000 18.27470 ? 546  TYR   A N   1 
ATOM   1416 C CA  . TYR   A 1 191 ? 12.44012  -20.66258 35.49406  1.000 15.53677 ? 546  TYR   A CA  1 
ATOM   1417 C C   . TYR   A 1 191 ? 11.70514  -19.45326 34.92111  1.000 20.34333 ? 546  TYR   A C   1 
ATOM   1418 O O   . TYR   A 1 191 ? 10.47740  -19.51990 34.73324  1.000 18.09729 ? 546  TYR   A O   1 
ATOM   1419 C CB  . TYR   A 1 191 ? 11.80034  -21.07171 36.82169  1.000 16.59908 ? 546  TYR   A CB  1 
ATOM   1420 C CG  . TYR   A 1 191 ? 12.37871  -22.34537 37.39724  1.000 17.48663 ? 546  TYR   A CG  1 
ATOM   1421 C CD1 . TYR   A 1 191 ? 12.05386  -23.58147 36.84766  1.000 24.79291 ? 546  TYR   A CD1 1 
ATOM   1422 C CD2 . TYR   A 1 191 ? 13.24376  -22.31439 38.47927  1.000 22.78011 ? 546  TYR   A CD2 1 
ATOM   1423 C CE1 . TYR   A 1 191 ? 12.61044  -24.72883 37.34157  1.000 20.39029 ? 546  TYR   A CE1 1 
ATOM   1424 C CE2 . TYR   A 1 191 ? 13.74448  -23.46850 39.00687  1.000 23.32111 ? 546  TYR   A CE2 1 
ATOM   1425 C CZ  . TYR   A 1 191 ? 13.41756  -24.65905 38.44251  1.000 21.92765 ? 546  TYR   A CZ  1 
ATOM   1426 O OH  . TYR   A 1 191 ? 13.94095  -25.84328 38.95767  1.000 22.49893 ? 546  TYR   A OH  1 
ATOM   1427 N N   . TYR   A 1 192 ? 12.40413  -18.33025 34.74216  1.000 16.38257 ? 547  TYR   A N   1 
ATOM   1428 C CA  . TYR   A 1 192 ? 11.78297  -17.08109 34.26141  1.000 17.65095 ? 547  TYR   A CA  1 
ATOM   1429 C C   . TYR   A 1 192 ? 10.68799  -16.57797 35.19179  1.000 16.99009 ? 547  TYR   A C   1 
ATOM   1430 O O   . TYR   A 1 192 ? 9.76745   -15.88847 34.74443  1.000 18.34521 ? 547  TYR   A O   1 
ATOM   1431 C CB  . TYR   A 1 192 ? 11.21753  -17.23459 32.85335  1.000 21.16055 ? 547  TYR   A CB  1 
ATOM   1432 C CG  . TYR   A 1 192 ? 12.20938  -17.46187 31.74813  1.000 22.70125 ? 547  TYR   A CG  1 
ATOM   1433 C CD1 . TYR   A 1 192 ? 13.55888  -17.59909 31.98471  1.000 25.73795 ? 547  TYR   A CD1 1 
ATOM   1434 C CD2 . TYR   A 1 192 ? 11.77729  -17.51341 30.43147  1.000 42.87276 ? 547  TYR   A CD2 1 
ATOM   1435 C CE1 . TYR   A 1 192 ? 14.45650  -17.80616 30.94032  1.000 35.18709 ? 547  TYR   A CE1 1 
ATOM   1436 C CE2 . TYR   A 1 192 ? 12.66194  -17.71238 29.38685  1.000 42.87162 ? 547  TYR   A CE2 1 
ATOM   1437 C CZ  . TYR   A 1 192 ? 13.99759  -17.85554 29.64755  1.000 49.69942 ? 547  TYR   A CZ  1 
ATOM   1438 O OH  . TYR   A 1 192 ? 14.87268  -18.05159 28.60606  1.000 46.26776 ? 547  TYR   A OH  1 
ATOM   1439 N N   . LYS   A 1 193 ? 10.79343  -16.80453 36.50024  1.000 14.80695 ? 548  LYS   A N   1 
ATOM   1440 C CA  . LYS   A 1 193 ? 9.76261   -16.44398 37.45803  1.000 17.63081 ? 548  LYS   A CA  1 
ATOM   1441 C C   . LYS   A 1 193 ? 10.29654  -15.27513 38.28699  1.000 17.96304 ? 548  LYS   A C   1 
ATOM   1442 O O   . LYS   A 1 193 ? 11.39842  -15.37087 38.84988  1.000 19.38071 ? 548  LYS   A O   1 
ATOM   1443 C CB  . LYS   A 1 193 ? 9.41958   -17.63718 38.35728  1.000 20.54728 ? 548  LYS   A CB  1 
ATOM   1444 C CG  . LYS   A 1 193 ? 8.78280   -18.79989 37.55325  1.000 23.06014 ? 548  LYS   A CG  1 
ATOM   1445 C CD  . LYS   A 1 193 ? 8.46994   -19.99146 38.48442  1.000 25.07247 ? 548  LYS   A CD  1 
ATOM   1446 C CE  . LYS   A 1 193 ? 7.49457   -19.61551 39.59248  1.000 29.13965 ? 548  LYS   A CE  1 
ATOM   1447 N NZ  . LYS   A 1 193 ? 7.10906   -20.80836 40.43283  1.000 39.29498 ? 548  LYS   A NZ  1 
ATOM   1448 N N   . PHE   A 1 194 ? 9.55241   -14.16572 38.31496  1.000 17.97601 ? 549  PHE   A N   1 
ATOM   1449 C CA  . PHE   A 1 194 ? 9.96821   -12.93559 38.99653  1.000 15.85036 ? 549  PHE   A CA  1 
ATOM   1450 C C   . PHE   A 1 194 ? 8.95844   -12.59500 40.07673  1.000 17.65238 ? 549  PHE   A C   1 
ATOM   1451 O O   . PHE   A 1 194 ? 7.78698   -12.33174 39.78337  1.000 18.72242 ? 549  PHE   A O   1 
ATOM   1452 C CB  . PHE   A 1 194 ? 10.09546  -11.76840 37.99223  1.000 15.03433 ? 549  PHE   A CB  1 
ATOM   1453 C CG  . PHE   A 1 194 ? 11.12520  -11.96759 36.96287  1.000 14.89164 ? 549  PHE   A CG  1 
ATOM   1454 C CD1 . PHE   A 1 194 ? 10.90716  -12.76033 35.83171  1.000 14.50376 ? 549  PHE   A CD1 1 
ATOM   1455 C CD2 . PHE   A 1 194 ? 12.38147  -11.38098 37.14336  1.000 15.89664 ? 549  PHE   A CD2 1 
ATOM   1456 C CE1 . PHE   A 1 194 ? 11.90587  -12.92635 34.89526  1.000 15.10227 ? 549  PHE   A CE1 1 
ATOM   1457 C CE2 . PHE   A 1 194 ? 13.37205  -11.52577 36.20770  1.000 16.93022 ? 549  PHE   A CE2 1 
ATOM   1458 C CZ  . PHE   A 1 194 ? 13.16064  -12.30432 35.09065  1.000 16.74337 ? 549  PHE   A CZ  1 
ATOM   1459 N N   . SER   A 1 195 ? 9.38347   -12.59131 41.32047  1.000 15.24622 ? 550  SER   A N   1 
ATOM   1460 C CA  . SER   A 1 195 ? 8.56284   -12.29315 42.48829  1.000 15.59847 ? 550  SER   A CA  1 
ATOM   1461 C C   . SER   A 1 195 ? 9.20943   -11.17337 43.28079  1.000 15.64249 ? 550  SER   A C   1 
ATOM   1462 O O   . SER   A 1 195 ? 10.33584  -10.73070 42.96897  1.000 14.28779 ? 550  SER   A O   1 
ATOM   1463 C CB  . SER   A 1 195 ? 8.43063   -13.52955 43.36479  1.000 19.60120 ? 550  SER   A CB  1 
ATOM   1464 O OG  . SER   A 1 195 ? 9.75879   -13.92870 43.79291  1.000 17.42219 ? 550  SER   A OG  1 
ATOM   1465 N N   . SER   A 1 196 ? 8.52933   -10.72868 44.33985  1.000 14.34675 ? 551  SER   A N   1 
ATOM   1466 C CA  . SER   A 1 196 ? 9.19062   -9.79037  45.23959  1.000 13.71999 ? 551  SER   A CA  1 
ATOM   1467 C C   . SER   A 1 196 ? 10.43765  -10.40697 45.86392  1.000 14.81185 ? 551  SER   A C   1 
ATOM   1468 O O   . SER   A 1 196 ? 11.45041  -9.70576  46.04385  1.000 14.17379 ? 551  SER   A O   1 
ATOM   1469 C CB  . SER   A 1 196 ? 8.24652   -9.31129  46.32483  1.000 17.08977 ? 551  SER   A CB  1 
ATOM   1470 O OG  . SER   A 1 196 ? 7.26088   -8.45495  45.74789  1.000 22.11111 ? 551  SER   A OG  1 
ATOM   1471 N N   . LYS   A 1 197 ? 10.40380  -11.71601 46.15521  1.000 15.53834 ? 552  LYS   A N   1 
ATOM   1472 C CA  . LYS   A 1 197 ? 11.62078  -12.39848 46.61487  1.000 15.84542 ? 552  LYS   A CA  1 
ATOM   1473 C C   . LYS   A 1 197 ? 12.75132  -12.28061 45.59836  1.000 14.75758 ? 552  LYS   A C   1 
ATOM   1474 O O   . LYS   A 1 197 ? 13.93209  -12.18112 45.99123  1.000 12.35638 ? 552  LYS   A O   1 
ATOM   1475 C CB  . LYS   A 1 197 ? 11.37269  -13.89669 46.89440  1.000 19.44187 ? 552  LYS   A CB  1 
ATOM   1476 C CG  . LYS   A 1 197 ? 10.37427  -14.29655 47.96391  1.000 31.50047 ? 552  LYS   A CG  1 
ATOM   1477 C CD  . LYS   A 1 197 ? 10.84090  -13.98074 49.35806  1.000 30.82518 ? 552  LYS   A CD  1 
ATOM   1478 C CE  . LYS   A 1 197 ? 9.91379   -14.57801 50.46263  1.000 19.29210 ? 552  LYS   A CE  1 
ATOM   1479 N NZ  . LYS   A 1 197 ? 10.12387  -16.02394 50.93429  1.000 26.75237 ? 552  LYS   A NZ  1 
ATOM   1480 N N   . SER   A 1 198 ? 12.45512  -12.34072 44.29193  1.000 13.76376 ? 553  SER   A N   1 
ATOM   1481 C CA  . SER   A 1 198 ? 13.51735  -12.13318 43.31694  1.000 12.53721 ? 553  SER   A CA  1 
ATOM   1482 C C   . SER   A 1 198 ? 14.08451  -10.71578 43.42911  1.000 12.33328 ? 553  SER   A C   1 
ATOM   1483 O O   . SER   A 1 198 ? 15.31211  -10.51400 43.35363  1.000 12.64177 ? 553  SER   A O   1 
ATOM   1484 C CB  . SER   A 1 198 ? 13.01511  -12.37890 41.88974  1.000 17.52961 ? 553  SER   A CB  1 
ATOM   1485 O OG  . SER   A 1 198 ? 12.20518  -13.59145 41.88661  1.000 19.34707 ? 553  SER   A OG  1 
ATOM   1486 N N   . ASP   A 1 199 ? 13.22802  -9.72431  43.68316  1.000 10.92150 ? 554  ASP   A N   1 
ATOM   1487 C CA  . ASP   A 1 199 ? 13.73780  -8.38212  43.90998  1.000 11.95065 ? 554  ASP   A CA  1 
ATOM   1488 C C   . ASP   A 1 199 ? 14.61190  -8.31841  45.14994  1.000 13.05372 ? 554  ASP   A C   1 
ATOM   1489 O O   . ASP   A 1 199 ? 15.54358  -7.51029  45.19007  1.000 11.30384 ? 554  ASP   A O   1 
ATOM   1490 C CB  . ASP   A 1 199 ? 12.58261  -7.32858  44.04621  1.000 12.20747 ? 554  ASP   A CB  1 
ATOM   1491 C CG  . ASP   A 1 199 ? 11.89235  -6.96058  42.71658  1.000 14.94055 ? 554  ASP   A CG  1 
ATOM   1492 O OD1 . ASP   A 1 199 ? 12.47701  -7.03041  41.59869  1.000 14.04255 ? 554  ASP   A OD1 1 
ATOM   1493 O OD2 . ASP   A 1 199 ? 10.72750  -6.50255  42.85513  1.000 14.64612 ? 554  ASP   A OD2 1 
ATOM   1494 N N   . VAL   A 1 200 ? 14.30660  -9.12673  46.20126  1.000 12.99563 ? 555  VAL   A N   1 
ATOM   1495 C CA  . VAL   A 1 200 ? 15.20207  -9.18823  47.37130  1.000 12.20435 ? 555  VAL   A CA  1 
ATOM   1496 C C   . VAL   A 1 200 ? 16.61907  -9.61842  46.96198  1.000 11.09250 ? 555  VAL   A C   1 
ATOM   1497 O O   . VAL   A 1 200 ? 17.61372  -9.06261  47.46130  1.000 11.97894 ? 555  VAL   A O   1 
ATOM   1498 C CB  . VAL   A 1 200 ? 14.59307  -10.11886 48.43777  1.000 11.68190 ? 555  VAL   A CB  1 
ATOM   1499 C CG1 . VAL   A 1 200 ? 15.59096  -10.40443 49.58686  1.000 11.48794 ? 555  VAL   A CG1 1 
ATOM   1500 C CG2 . VAL   A 1 200 ? 13.31627  -9.49248  49.04930  1.000 14.24671 ? 555  VAL   A CG2 1 
ATOM   1501 N N   . TRP   A 1 201 ? 16.74624  -10.62118 46.10300  1.000 11.31269 ? 556  TRP   A N   1 
ATOM   1502 C CA  . TRP   A 1 201 ? 18.08767  -11.01803 45.64606  1.000 10.27492 ? 556  TRP   A CA  1 
ATOM   1503 C C   . TRP   A 1 201 ? 18.79495  -9.81048  45.02740  1.000 11.77786 ? 556  TRP   A C   1 
ATOM   1504 O O   . TRP   A 1 201 ? 19.97075  -9.50373  45.34595  1.000 11.18062 ? 556  TRP   A O   1 
ATOM   1505 C CB  . TRP   A 1 201 ? 17.96786  -12.17898 44.65010  1.000 13.11443 ? 556  TRP   A CB  1 
ATOM   1506 C CG  . TRP   A 1 201 ? 19.28617  -12.60743 44.12224  1.000 12.02726 ? 556  TRP   A CG  1 
ATOM   1507 C CD1 . TRP   A 1 201 ? 20.08754  -11.94336 43.18972  1.000 11.43326 ? 556  TRP   A CD1 1 
ATOM   1508 C CD2 . TRP   A 1 201 ? 19.97733  -13.82414 44.45206  1.000 11.79687 ? 556  TRP   A CD2 1 
ATOM   1509 N NE1 . TRP   A 1 201 ? 21.25974  -12.65976 42.98646  1.000 11.77896 ? 556  TRP   A NE1 1 
ATOM   1510 C CE2 . TRP   A 1 201 ? 21.20901  -13.80562 43.74604  1.000 11.55546 ? 556  TRP   A CE2 1 
ATOM   1511 C CE3 . TRP   A 1 201 ? 19.67657  -14.92605 45.26737  1.000 12.72396 ? 556  TRP   A CE3 1 
ATOM   1512 C CZ2 . TRP   A 1 201 ? 22.13287  -14.80705 43.84037  1.000 11.09531 ? 556  TRP   A CZ2 1 
ATOM   1513 C CZ3 . TRP   A 1 201 ? 20.61501  -15.95763 45.33207  1.000 14.10534 ? 556  TRP   A CZ3 1 
ATOM   1514 C CH2 . TRP   A 1 201 ? 21.81383  -15.87827 44.64932  1.000 12.54196 ? 556  TRP   A CH2 1 
ATOM   1515 N N   . SER   A 1 202 ? 18.09367  -9.12466  44.09452  1.000 9.61293  ? 557  SER   A N   1 
ATOM   1516 C CA  . SER   A 1 202 ? 18.66607  -7.95026  43.44041  1.000 10.27834 ? 557  SER   A CA  1 
ATOM   1517 C C   . SER   A 1 202 ? 19.06052  -6.91492  44.46711  1.000 11.41028 ? 557  SER   A C   1 
ATOM   1518 O O   . SER   A 1 202 ? 20.09088  -6.25920  44.32253  1.000 11.16456 ? 557  SER   A O   1 
ATOM   1519 C CB  . SER   A 1 202 ? 17.64190  -7.31730  42.51029  1.000 12.77722 ? 557  SER   A CB  1 
ATOM   1520 O OG  . SER   A 1 202 ? 17.10702  -8.30752  41.65372  1.000 16.48011 ? 557  SER   A OG  1 
ATOM   1521 N N   . PHE   A 1 203 ? 18.23790  -6.74455  45.50222  1.000 11.32598 ? 558  PHE   A N   1 
ATOM   1522 C CA  . PHE   A 1 203 ? 18.55838  -5.80209  46.56238  1.000 10.59577 ? 558  PHE   A CA  1 
ATOM   1523 C C   . PHE   A 1 203 ? 19.87562  -6.16267  47.27101  1.000 9.63987  ? 558  PHE   A C   1 
ATOM   1524 O O   . PHE   A 1 203 ? 20.64398  -5.26351  47.65107  1.000 11.25059 ? 558  PHE   A O   1 
ATOM   1525 C CB  . PHE   A 1 203 ? 17.38989  -5.74561  47.55841  1.000 12.57643 ? 558  PHE   A CB  1 
ATOM   1526 C CG  . PHE   A 1 203 ? 17.61693  -4.77217  48.67225  1.000 10.53775 ? 558  PHE   A CG  1 
ATOM   1527 C CD1 . PHE   A 1 203 ? 17.54270  -3.38311  48.45326  1.000 11.72109 ? 558  PHE   A CD1 1 
ATOM   1528 C CD2 . PHE   A 1 203 ? 17.99997  -5.24244  49.92656  1.000 12.20376 ? 558  PHE   A CD2 1 
ATOM   1529 C CE1 . PHE   A 1 203 ? 17.75536  -2.48480  49.53016  1.000 12.95773 ? 558  PHE   A CE1 1 
ATOM   1530 C CE2 . PHE   A 1 203 ? 18.26183  -4.37040  50.98282  1.000 11.28372 ? 558  PHE   A CE2 1 
ATOM   1531 C CZ  . PHE   A 1 203 ? 18.12556  -3.00117  50.81344  1.000 11.47087 ? 558  PHE   A CZ  1 
ATOM   1532 N N   . GLY   A 1 204 ? 20.15712  -7.44587  47.43926  1.000 10.93427 ? 559  GLY   A N   1 
ATOM   1533 C CA  . GLY   A 1 204 ? 21.46503  -7.82854  47.97526  1.000 11.58055 ? 559  GLY   A CA  1 
ATOM   1534 C C   . GLY   A 1 204 ? 22.61258  -7.35355  47.09316  1.000 10.25491 ? 559  GLY   A C   1 
ATOM   1535 O O   . GLY   A 1 204 ? 23.66336  -6.89335  47.58005  1.000 11.60880 ? 559  GLY   A O   1 
ATOM   1536 N N   . VAL   A 1 205 ? 22.44891  -7.48646  45.76339  1.000 9.43000  ? 560  VAL   A N   1 
ATOM   1537 C CA  . VAL   A 1 205 ? 23.46669  -7.00564  44.86228  1.000 9.55336  ? 560  VAL   A CA  1 
ATOM   1538 C C   . VAL   A 1 205 ? 23.58053  -5.48857  44.96088  1.000 12.21080 ? 560  VAL   A C   1 
ATOM   1539 O O   . VAL   A 1 205 ? 24.68737  -4.94742  45.01536  1.000 9.78629  ? 560  VAL   A O   1 
ATOM   1540 C CB  . VAL   A 1 205 ? 23.15058  -7.43368  43.41692  1.000 9.79339  ? 560  VAL   A CB  1 
ATOM   1541 C CG1 . VAL   A 1 205 ? 24.27224  -7.02180  42.49299  1.000 12.52790 ? 560  VAL   A CG1 1 
ATOM   1542 C CG2 . VAL   A 1 205 ? 23.05651  -8.96073  43.35004  1.000 11.54409 ? 560  VAL   A CG2 1 
ATOM   1543 N N   . LEU   A 1 206 ? 22.43685  -4.78939  45.02506  1.000 10.69248 ? 561  LEU   A N   1 
ATOM   1544 C CA  . LEU   A 1 206 ? 22.44842  -3.34875  45.23612  1.000 9.71167  ? 561  LEU   A CA  1 
ATOM   1545 C C   . LEU   A 1 206 ? 23.18645  -2.97408  46.51496  1.000 11.07662 ? 561  LEU   A C   1 
ATOM   1546 O O   . LEU   A 1 206 ? 23.96756  -2.01093  46.49416  1.000 10.54160 ? 561  LEU   A O   1 
ATOM   1547 C CB  . LEU   A 1 206 ? 21.00095  -2.84409  45.25274  1.000 10.08974 ? 561  LEU   A CB  1 
ATOM   1548 C CG  . LEU   A 1 206 ? 20.68652  -1.38850  45.32041  1.000 11.43013 ? 561  LEU   A CG  1 
ATOM   1549 C CD1 . LEU   A 1 206 ? 19.22212  -1.18375  44.79310  1.000 14.90828 ? 561  LEU   A CD1 1 
ATOM   1550 C CD2 . LEU   A 1 206 ? 20.83606  -0.86969  46.74448  1.000 16.00865 ? 561  LEU   A CD2 1 
ATOM   1551 N N   . MET   A 1 207 ? 22.93537  -3.68801  47.61787  1.000 11.17067 ? 562  MET   A N   1 
ATOM   1552 C CA  . MET   A 1 207 ? 23.67422  -3.39510  48.85034  1.000 12.97744 ? 562  MET   A CA  1 
ATOM   1553 C C   . MET   A 1 207 ? 25.16089  -3.53258  48.59934  1.000 11.17453 ? 562  MET   A C   1 
ATOM   1554 O O   . MET   A 1 207 ? 25.95745  -2.68065  49.02371  1.000 13.43915 ? 562  MET   A O   1 
ATOM   1555 C CB  . MET   A 1 207 ? 23.32436  -4.35768  49.98974  1.000 12.84916 ? 562  MET   A CB  1 
ATOM   1556 C CG  . MET   A 1 207 ? 21.90629  -4.19740  50.52725  1.000 18.35870 ? 562  MET   A CG  1 
ATOM   1557 S SD  . MET   A 1 207 ? 21.61369  -5.36473  51.93557  1.000 19.08592 ? 562  MET   A SD  1 
ATOM   1558 C CE  . MET   A 1 207 ? 22.83602  -4.74280  53.14151  1.000 16.73692 ? 562  MET   A CE  1 
ATOM   1559 N N   . TRP   A 1 208 ? 25.55575  -4.64612  47.97195  1.000 11.41025 ? 563  TRP   A N   1 
ATOM   1560 C CA  . TRP   A 1 208 ? 26.98103  -4.82964  47.68664  1.000 12.15622 ? 563  TRP   A CA  1 
ATOM   1561 C C   . TRP   A 1 208 ? 27.53418  -3.66038  46.88332  1.000 11.70038 ? 563  TRP   A C   1 
ATOM   1562 O O   . TRP   A 1 208 ? 28.62060  -3.11676  47.19781  1.000 11.98139 ? 563  TRP   A O   1 
ATOM   1563 C CB  . TRP   A 1 208 ? 27.18358  -6.18450  46.96036  1.000 11.19120 ? 563  TRP   A CB  1 
ATOM   1564 C CG  . TRP   A 1 208 ? 28.65063  -6.52546  46.78283  1.000 12.04218 ? 563  TRP   A CG  1 
ATOM   1565 C CD1 . TRP   A 1 208 ? 29.44862  -7.30516  47.62986  1.000 12.67654 ? 563  TRP   A CD1 1 
ATOM   1566 C CD2 . TRP   A 1 208 ? 29.50010  -6.01107  45.76626  1.000 12.39191 ? 563  TRP   A CD2 1 
ATOM   1567 N NE1 . TRP   A 1 208 ? 30.74254  -7.30930  47.12661  1.000 13.82364 ? 563  TRP   A NE1 1 
ATOM   1568 C CE2 . TRP   A 1 208 ? 30.81150  -6.51993  46.01649  1.000 11.42859 ? 563  TRP   A CE2 1 
ATOM   1569 C CE3 . TRP   A 1 208 ? 29.29718  -5.16029  44.65573  1.000 11.55488 ? 563  TRP   A CE3 1 
ATOM   1570 C CZ2 . TRP   A 1 208 ? 31.91608  -6.19539  45.16963  1.000 15.26525 ? 563  TRP   A CZ2 1 
ATOM   1571 C CZ3 . TRP   A 1 208 ? 30.42570  -4.84619  43.78633  1.000 13.50381 ? 563  TRP   A CZ3 1 
ATOM   1572 C CH2 . TRP   A 1 208 ? 31.69004  -5.36332  44.07668  1.000 16.60724 ? 563  TRP   A CH2 1 
ATOM   1573 N N   . GLU   A 1 209 ? 26.78705  -3.21238  45.86743  1.000 10.21729 ? 564  GLU   A N   1 
ATOM   1574 C CA  . GLU   A 1 209 ? 27.23888  -2.08982  45.05422  1.000 10.37387 ? 564  GLU   A CA  1 
ATOM   1575 C C   . GLU   A 1 209 ? 27.41906  -0.83551  45.90261  1.000 14.22628 ? 564  GLU   A C   1 
ATOM   1576 O O   . GLU   A 1 209 ? 28.40588  -0.10845  45.75762  1.000 13.55954 ? 564  GLU   A O   1 
ATOM   1577 C CB  . GLU   A 1 209 ? 26.21467  -1.79820  43.96795  1.000 12.18230 ? 564  GLU   A CB  1 
ATOM   1578 C CG  . GLU   A 1 209 ? 26.11021  -2.82501  42.84973  1.000 12.29097 ? 564  GLU   A CG  1 
ATOM   1579 C CD  . GLU   A 1 209 ? 25.04116  -2.34000  41.91006  1.000 12.87682 ? 564  GLU   A CD  1 
ATOM   1580 O OE1 . GLU   A 1 209 ? 23.80733  -2.53010  42.13420  1.000 13.45749 ? 564  GLU   A OE1 1 
ATOM   1581 O OE2 . GLU   A 1 209 ? 25.42380  -1.67572  40.93008  1.000 14.56172 ? 564  GLU   A OE2 1 
ATOM   1582 N N   . ALA   A 1 210 ? 26.45509  -0.54533  46.76501  1.000 11.05678 ? 565  ALA   A N   1 
ATOM   1583 C CA  . ALA   A 1 210 ? 26.50204  0.68264   47.56993  1.000 11.79750 ? 565  ALA   A CA  1 
ATOM   1584 C C   . ALA   A 1 210 ? 27.67190  0.65787   48.55459  1.000 14.91978 ? 565  ALA   A C   1 
ATOM   1585 O O   . ALA   A 1 210 ? 28.40520  1.63726   48.66657  1.000 13.83300 ? 565  ALA   A O   1 
ATOM   1586 C CB  . ALA   A 1 210 ? 25.17089  0.83345   48.30672  1.000 13.76863 ? 565  ALA   A CB  1 
ATOM   1587 N N   . PHE   A 1 211 ? 27.84908  -0.45776  49.27930  1.000 11.62928 ? 566  PHE   A N   1 
ATOM   1588 C CA  . PHE   A 1 211 ? 28.96396  -0.55088  50.22607  1.000 12.53218 ? 566  PHE   A CA  1 
ATOM   1589 C C   . PHE   A 1 211 ? 30.30517  -0.62175  49.48311  1.000 13.39354 ? 566  PHE   A C   1 
ATOM   1590 O O   . PHE   A 1 211 ? 31.35837  -0.37082  50.10691  1.000 16.37792 ? 566  PHE   A O   1 
ATOM   1591 C CB  . PHE   A 1 211 ? 28.75729  -1.74906  51.16194  1.000 13.65379 ? 566  PHE   A CB  1 
ATOM   1592 C CG  . PHE   A 1 211 ? 27.72961  -1.47332  52.20959  1.000 13.22490 ? 566  PHE   A CG  1 
ATOM   1593 C CD1 . PHE   A 1 211 ? 28.04086  -0.67046  53.29885  1.000 17.46775 ? 566  PHE   A CD1 1 
ATOM   1594 C CD2 . PHE   A 1 211 ? 26.46684  -1.97284  52.09768  1.000 16.36291 ? 566  PHE   A CD2 1 
ATOM   1595 C CE1 . PHE   A 1 211 ? 27.08404  -0.36346  54.26672  1.000 17.84825 ? 566  PHE   A CE1 1 
ATOM   1596 C CE2 . PHE   A 1 211 ? 25.50124  -1.69286  53.06297  1.000 15.12178 ? 566  PHE   A CE2 1 
ATOM   1597 C CZ  . PHE   A 1 211 ? 25.80518  -0.87201  54.14905  1.000 17.25777 ? 566  PHE   A CZ  1 
ATOM   1598 N N   . SER   A 1 212 ? 30.30371  -0.92479  48.16780  1.000 12.74890 ? 567  SER   A N   1 
ATOM   1599 C CA  . SER   A 1 212 ? 31.48857  -0.87414  47.33021  1.000 12.40977 ? 567  SER   A CA  1 
ATOM   1600 C C   . SER   A 1 212 ? 31.64232  0.45938   46.60187  1.000 14.05005 ? 567  SER   A C   1 
ATOM   1601 O O   . SER   A 1 212 ? 32.41491  0.55992   45.64131  1.000 14.98226 ? 567  SER   A O   1 
ATOM   1602 C CB  . SER   A 1 212 ? 31.42776  -2.02357  46.31690  1.000 11.46097 ? 567  SER   A CB  1 
ATOM   1603 O OG  . SER   A 1 212 ? 31.35445  -3.25492  46.99007  1.000 13.78239 ? 567  SER   A OG  1 
ATOM   1604 N N   . TYR   A 1 213 ? 30.87503  1.48556   46.99709  1.000 14.44226 ? 568  TYR   A N   1 
ATOM   1605 C CA  . TYR   A 1 213 ? 30.96375  2.82748   46.39308  1.000 15.49414 ? 568  TYR   A CA  1 
ATOM   1606 C C   . TYR   A 1 213 ? 30.78802  2.81876   44.88375  1.000 16.76466 ? 568  TYR   A C   1 
ATOM   1607 O O   . TYR   A 1 213 ? 31.45053  3.53699   44.11216  1.000 18.27104 ? 568  TYR   A O   1 
ATOM   1608 C CB  . TYR   A 1 213 ? 32.25991  3.54389   46.79985  1.000 17.15462 ? 568  TYR   A CB  1 
ATOM   1609 C CG  . TYR   A 1 213 ? 32.25895  3.87048   48.25697  1.000 15.57698 ? 568  TYR   A CG  1 
ATOM   1610 C CD1 . TYR   A 1 213 ? 32.57063  2.91045   49.20334  1.000 16.12539 ? 568  TYR   A CD1 1 
ATOM   1611 C CD2 . TYR   A 1 213 ? 31.86301  5.13149   48.72142  1.000 16.65497 ? 568  TYR   A CD2 1 
ATOM   1612 C CE1 . TYR   A 1 213 ? 32.54064  3.19625   50.55725  1.000 17.24251 ? 568  TYR   A CE1 1 
ATOM   1613 C CE2 . TYR   A 1 213 ? 31.82999  5.41065   50.06067  1.000 19.23856 ? 568  TYR   A CE2 1 
ATOM   1614 C CZ  . TYR   A 1 213 ? 32.15712  4.44652   50.97295  1.000 20.13148 ? 568  TYR   A CZ  1 
ATOM   1615 O OH  . TYR   A 1 213 ? 32.17511  4.71379   52.30678  1.000 24.84408 ? 568  TYR   A OH  1 
ATOM   1616 N N   . GLY   A 1 214 ? 29.81842  2.01809   44.44815  1.000 13.80679 ? 569  GLY   A N   1 
ATOM   1617 C CA  . GLY   A 1 214 ? 29.47582  2.02620   43.03307  1.000 15.37220 ? 569  GLY   A CA  1 
ATOM   1618 C C   . GLY   A 1 214 ? 30.30554  1.17113   42.12247  1.000 15.61822 ? 569  GLY   A C   1 
ATOM   1619 O O   . GLY   A 1 214 ? 30.24627  1.35414   40.89426  1.000 19.72016 ? 569  GLY   A O   1 
ATOM   1620 N N   . GLN   A 1 215 ? 31.08769  0.26328   42.66441  1.000 16.51532 ? 570  GLN   A N   1 
ATOM   1621 C CA  . GLN   A 1 215 ? 31.76981  -0.69751  41.80645  1.000 17.60285 ? 570  GLN   A CA  1 
ATOM   1622 C C   . GLN   A 1 215 ? 30.75250  -1.62544  41.17186  1.000 18.52492 ? 570  GLN   A C   1 
ATOM   1623 O O   . GLN   A 1 215 ? 29.71853  -1.92707  41.74357  1.000 18.31417 ? 570  GLN   A O   1 
ATOM   1624 C CB  . GLN   A 1 215 ? 32.76004  -1.51328  42.61714  1.000 20.51147 ? 570  GLN   A CB  1 
ATOM   1625 C CG  . GLN   A 1 215 ? 33.86756  -0.65979  43.20094  1.000 33.78112 ? 570  GLN   A CG  1 
ATOM   1626 C CD  . GLN   A 1 215 ? 35.00497  -0.37259  42.22688  1.000 52.82102 ? 570  GLN   A CD  1 
ATOM   1627 O OE1 . GLN   A 1 215 ? 35.19142  -1.07943  41.22439  1.000 48.61076 ? 570  GLN   A OE1 1 
ATOM   1628 N NE2 . GLN   A 1 215 ? 35.77904  0.66639   42.52531  1.000 47.68204 ? 570  GLN   A NE2 1 
ATOM   1629 N N   . LYS   A 1 216 ? 31.05111  -2.08269  39.96964  1.000 16.45024 ? 571  LYS   A N   1 
ATOM   1630 C CA  . LYS   A 1 216 ? 30.17240  -3.06057  39.33050  1.000 16.28527 ? 571  LYS   A CA  1 
ATOM   1631 C C   . LYS   A 1 216 ? 30.28372  -4.40694  40.05374  1.000 15.47040 ? 571  LYS   A C   1 
ATOM   1632 O O   . LYS   A 1 216 ? 31.38425  -4.83118  40.40870  1.000 15.21687 ? 571  LYS   A O   1 
ATOM   1633 C CB  . LYS   A 1 216 ? 30.55302  -3.24440  37.85988  1.000 21.32117 ? 571  LYS   A CB  1 
ATOM   1634 C CG  . LYS   A 1 216 ? 30.27646  -2.05173  36.97496  1.000 27.97030 ? 571  LYS   A CG  1 
ATOM   1635 C CD  . LYS   A 1 216 ? 30.97246  -2.23856  35.59959  1.000 43.01285 ? 571  LYS   A CD  1 
ATOM   1636 C CE  . LYS   A 1 216 ? 30.49121  -1.22444  34.55659  1.000 51.70607 ? 571  LYS   A CE  1 
ATOM   1637 N NZ  . LYS   A 1 216 ? 29.62054  -1.84003  33.50358  1.000 58.58772 ? 571  LYS   A NZ  1 
ATOM   1638 N N   . PRO   A 1 217 ? 29.19122  -5.12592  40.23004  1.000 13.60244 ? 572  PRO   A N   1 
ATOM   1639 C CA  . PRO   A 1 217 ? 29.27516  -6.46877  40.82841  1.000 12.62975 ? 572  PRO   A CA  1 
ATOM   1640 C C   . PRO   A 1 217 ? 29.82687  -7.48622  39.82297  1.000 13.23469 ? 572  PRO   A C   1 
ATOM   1641 O O   . PRO   A 1 217 ? 29.71186  -7.30908  38.58954  1.000 15.02890 ? 572  PRO   A O   1 
ATOM   1642 C CB  . PRO   A 1 217 ? 27.80050  -6.77153  41.15541  1.000 14.41562 ? 572  PRO   A CB  1 
ATOM   1643 C CG  . PRO   A 1 217 ? 27.00617  -6.01533  40.06480  1.000 15.55379 ? 572  PRO   A CG  1 
ATOM   1644 C CD  . PRO   A 1 217 ? 27.82383  -4.78674  39.73071  1.000 16.14510 ? 572  PRO   A CD  1 
ATOM   1645 N N   . TYR   A 1 218 ? 30.37797  -8.59127  40.36066  1.000 13.16237 ? 573  TYR   A N   1 
ATOM   1646 C CA  . TYR   A 1 218 ? 30.91184  -9.70704  39.55547  1.000 12.35890 ? 573  TYR   A CA  1 
ATOM   1647 C C   . TYR   A 1 218 ? 31.85755  -9.17512  38.49413  1.000 13.45246 ? 573  TYR   A C   1 
ATOM   1648 O O   . TYR   A 1 218 ? 31.76498  -9.51343  37.29915  1.000 15.07286 ? 573  TYR   A O   1 
ATOM   1649 C CB  . TYR   A 1 218 ? 29.79853  -10.54432 38.91438  1.000 12.98524 ? 573  TYR   A CB  1 
ATOM   1650 C CG  . TYR   A 1 218 ? 28.83356  -11.05685 39.91346  1.000 12.34417 ? 573  TYR   A CG  1 
ATOM   1651 C CD1 . TYR   A 1 218 ? 29.11099  -12.16616 40.72398  1.000 11.31280 ? 573  TYR   A CD1 1 
ATOM   1652 C CD2 . TYR   A 1 218 ? 27.60117  -10.43340 40.03361  1.000 12.75548 ? 573  TYR   A CD2 1 
ATOM   1653 C CE1 . TYR   A 1 218 ? 28.19023  -12.62538 41.70520  1.000 10.50359 ? 573  TYR   A CE1 1 
ATOM   1654 C CE2 . TYR   A 1 218 ? 26.68596  -10.88708 40.98535  1.000 11.83677 ? 573  TYR   A CE2 1 
ATOM   1655 C CZ  . TYR   A 1 218 ? 26.98819  -11.97736 41.78963  1.000 10.91637 ? 573  TYR   A CZ  1 
ATOM   1656 O OH  . TYR   A 1 218 ? 26.04330  -12.44187 42.69158  1.000 13.24999 ? 573  TYR   A OH  1 
ATOM   1657 N N   . ARG   A 1 219 ? 32.79101  -8.32054  38.90954  1.000 15.71061 ? 574  ARG   A N   1 
ATOM   1658 C CA  . ARG   A 1 219 ? 33.57163  -7.65424  37.88673  1.000 17.99485 ? 574  ARG   A CA  1 
ATOM   1659 C C   . ARG   A 1 219 ? 34.44055  -8.63808  37.11429  1.000 14.78269 ? 574  ARG   A C   1 
ATOM   1660 O O   . ARG   A 1 219 ? 34.95999  -9.62080  37.64760  1.000 14.14408 ? 574  ARG   A O   1 
ATOM   1661 C CB  . ARG   A 1 219 ? 34.39366  -6.51768  38.47261  1.000 21.32205 ? 574  ARG   A CB  1 
ATOM   1662 C CG  . ARG   A 1 219 ? 35.61808  -6.88400  39.15347  1.000 20.42881 ? 574  ARG   A CG  1 
ATOM   1663 C CD  . ARG   A 1 219 ? 36.46096  -5.55235  39.37418  1.000 22.56694 ? 574  ARG   A CD  1 
ATOM   1664 N NE  . ARG   A 1 219 ? 37.53707  -5.85974  40.28155  1.000 18.73403 ? 574  ARG   A NE  1 
ATOM   1665 C CZ  . ARG   A 1 219 ? 38.07668  -5.03137  41.15655  1.000 22.25508 ? 574  ARG   A CZ  1 
ATOM   1666 N NH1 . ARG   A 1 219 ? 37.73518  -3.74630  41.20435  1.000 21.44143 ? 574  ARG   A NH1 1 
ATOM   1667 N NH2 . ARG   A 1 219 ? 38.96540  -5.50627  42.01568  1.000 23.02971 ? 574  ARG   A NH2 1 
ATOM   1668 N N   . GLY   A 1 220 ? 34.53837  -8.39575  35.82631  1.000 16.07965 ? 575  GLY   A N   1 
ATOM   1669 C CA  . GLY   A 1 220 ? 35.35407  -9.22871  34.97692  1.000 17.38528 ? 575  GLY   A CA  1 
ATOM   1670 C C   . GLY   A 1 220 ? 34.72640  -10.52370 34.53577  1.000 23.17781 ? 575  GLY   A C   1 
ATOM   1671 O O   . GLY   A 1 220 ? 35.39668  -11.30768 33.84651  1.000 22.56090 ? 575  GLY   A O   1 
ATOM   1672 N N   . MET   A 1 221 ? 33.47814  -10.77742 34.92314  1.000 16.05903 ? 576  MET   A N   1 
ATOM   1673 C CA  . MET   A 1 221 ? 32.80784  -12.05397 34.72051  1.000 15.80582 ? 576  MET   A CA  1 
ATOM   1674 C C   . MET   A 1 221 ? 31.69408  -11.95659 33.69437  1.000 19.17232 ? 576  MET   A C   1 
ATOM   1675 O O   . MET   A 1 221 ? 30.94112  -10.97490 33.64406  1.000 19.76996 ? 576  MET   A O   1 
ATOM   1676 C CB  . MET   A 1 221 ? 32.19384  -12.57674 36.00731  1.000 14.12972 ? 576  MET   A CB  1 
ATOM   1677 C CG  . MET   A 1 221 ? 33.27591  -12.84342 37.07929  1.000 15.07589 ? 576  MET   A CG  1 
ATOM   1678 S SD  . MET   A 1 221 ? 32.59224  -13.30031 38.67131  1.000 16.30418 ? 576  MET   A SD  1 
ATOM   1679 C CE  . MET   A 1 221 ? 31.88409  -14.92976 38.22612  1.000 18.99464 ? 576  MET   A CE  1 
ATOM   1680 N N   . LYS   A 1 222 ? 31.59255  -13.00976 32.87887  1.000 19.21551 ? 577  LYS   A N   1 
ATOM   1681 C CA  . LYS   A 1 222 ? 30.43888  -13.12583 32.00527  1.000 20.06520 ? 577  LYS   A CA  1 
ATOM   1682 C C   . LYS   A 1 222 ? 29.24422  -13.64826 32.78826  1.000 19.82766 ? 577  LYS   A C   1 
ATOM   1683 O O   . LYS   A 1 222 ? 29.38983  -14.29101 33.84088  1.000 18.80864 ? 577  LYS   A O   1 
ATOM   1684 C CB  . LYS   A 1 222 ? 30.70482  -14.09801 30.84255  1.000 28.18960 ? 577  LYS   A CB  1 
ATOM   1685 C CG  . LYS   A 1 222 ? 31.78796  -13.70869 29.87526  1.000 32.91385 ? 577  LYS   A CG  1 
ATOM   1686 C CD  . LYS   A 1 222 ? 32.07638  -14.90507 28.93945  1.000 37.10560 ? 577  LYS   A CD  1 
ATOM   1687 C CE  . LYS   A 1 222 ? 32.87782  -14.48307 27.71695  1.000 52.04798 ? 577  LYS   A CE  1 
ATOM   1688 N NZ  . LYS   A 1 222 ? 32.05571  -13.64804 26.78152  1.000 73.60764 ? 577  LYS   A NZ  1 
ATOM   1689 N N   . GLY   A 1 223 ? 28.06149  -13.41448 32.23151  1.000 23.86753 ? 578  GLY   A N   1 
ATOM   1690 C CA  . GLY   A 1 223 ? 26.84924  -13.94149 32.83748  1.000 26.68191 ? 578  GLY   A CA  1 
ATOM   1691 C C   . GLY   A 1 223 ? 26.92848  -15.42247 33.15466  1.000 25.33220 ? 578  GLY   A C   1 
ATOM   1692 O O   . GLY   A 1 223 ? 26.52464  -15.85776 34.22932  1.000 21.37927 ? 578  GLY   A O   1 
ATOM   1693 N N   . SER   A 1 224 ? 27.42319  -16.23572 32.21008  1.000 22.69432 ? 579  SER   A N   1 
ATOM   1694 C CA  . SER   A 1 224 ? 27.48107  -17.67372 32.47299  1.000 23.18405 ? 579  SER   A CA  1 
ATOM   1695 C C   . SER   A 1 224 ? 28.43241  -18.00258 33.60498  1.000 19.84602 ? 579  SER   A C   1 
ATOM   1696 O O   . SER   A 1 224 ? 28.23601  -18.99044 34.32451  1.000 23.05171 ? 579  SER   A O   1 
ATOM   1697 C CB  . SER   A 1 224 ? 27.92949  -18.43110 31.21939  1.000 25.23196 ? 579  SER   A CB  1 
ATOM   1698 O OG  . SER   A 1 224 ? 29.12118  -17.86290 30.69968  1.000 32.21920 ? 579  SER   A OG  1 
ATOM   1699 N N   . GLU   A 1 225 ? 29.47340  -17.17017 33.78323  1.000 18.76618 ? 580  GLU   A N   1 
ATOM   1700 C CA  . GLU   A 1 225 ? 30.41462  -17.38051 34.85754  1.000 19.43338 ? 580  GLU   A CA  1 
ATOM   1701 C C   . GLU   A 1 225 ? 29.77652  -16.99970 36.20114  1.000 15.95582 ? 580  GLU   A C   1 
ATOM   1702 O O   . GLU   A 1 225 ? 30.03975  -17.65711 37.22196  1.000 17.48858 ? 580  GLU   A O   1 
ATOM   1703 C CB  . GLU   A 1 225 ? 31.68414  -16.57249 34.56586  1.000 21.65104 ? 580  GLU   A CB  1 
ATOM   1704 C CG  . GLU   A 1 225 ? 32.44709  -17.11295 33.31832  1.000 21.87857 ? 580  GLU   A CG  1 
ATOM   1705 C CD  . GLU   A 1 225 ? 33.61781  -16.24290 32.91497  1.000 28.12717 ? 580  GLU   A CD  1 
ATOM   1706 O OE1 . GLU   A 1 225 ? 33.57962  -14.98994 33.04022  1.000 24.47223 ? 580  GLU   A OE1 1 
ATOM   1707 O OE2 . GLU   A 1 225 ? 34.60308  -16.82248 32.40829  1.000 30.70314 ? 580  GLU   A OE2 1 
ATOM   1708 N N   . VAL   A 1 226 ? 28.89480  -16.00025 36.19498  1.000 16.81354 ? 581  VAL   A N   1 
ATOM   1709 C CA  . VAL   A 1 226 ? 28.15254  -15.66290 37.40642  1.000 15.59462 ? 581  VAL   A CA  1 
ATOM   1710 C C   . VAL   A 1 226 ? 27.23252  -16.80297 37.80949  1.000 18.36140 ? 581  VAL   A C   1 
ATOM   1711 O O   . VAL   A 1 226 ? 27.19089  -17.21067 38.97869  1.000 15.42221 ? 581  VAL   A O   1 
ATOM   1712 C CB  . VAL   A 1 226 ? 27.36951  -14.36767 37.19022  1.000 14.50414 ? 581  VAL   A CB  1 
ATOM   1713 C CG1 . VAL   A 1 226 ? 26.50327  -14.08473 38.41404  1.000 16.43017 ? 581  VAL   A CG1 1 
ATOM   1714 C CG2 . VAL   A 1 226 ? 28.34272  -13.25837 37.01277  1.000 19.52908 ? 581  VAL   A CG2 1 
ATOM   1715 N N   . THR   A 1 227 ? 26.43962  -17.31418 36.84426  1.000 19.69275 ? 582  THR   A N   1 
ATOM   1716 C CA  . THR   A 1 227 ? 25.58945  -18.46507 37.12353  1.000 19.73141 ? 582  THR   A CA  1 
ATOM   1717 C C   . THR   A 1 227 ? 26.40281  -19.63633 37.65553  1.000 17.93124 ? 582  THR   A C   1 
ATOM   1718 O O   . THR   A 1 227 ? 26.00814  -20.29336 38.62626  1.000 20.59383 ? 582  THR   A O   1 
ATOM   1719 C CB  . THR   A 1 227 ? 24.82060  -18.84600 35.84620  1.000 22.76101 ? 582  THR   A CB  1 
ATOM   1720 O OG1 . THR   A 1 227 ? 24.03872  -17.72990 35.43026  1.000 31.49406 ? 582  THR   A OG1 1 
ATOM   1721 C CG2 . THR   A 1 227 ? 23.88427  -20.01416 36.11916  1.000 34.84459 ? 582  THR   A CG2 1 
ATOM   1722 N N   . ALA   A 1 228 ? 27.55358  -19.89829 37.06142  1.000 18.63914 ? 583  ALA   A N   1 
ATOM   1723 C CA  . ALA   A 1 228 ? 28.38913  -20.99000 37.53492  1.000 20.57100 ? 583  ALA   A CA  1 
ATOM   1724 C C   . ALA   A 1 228 ? 28.90216  -20.74991 38.94928  1.000 21.95016 ? 583  ALA   A C   1 
ATOM   1725 O O   . ALA   A 1 228 ? 28.89672  -21.65403 39.77120  1.000 20.80667 ? 583  ALA   A O   1 
ATOM   1726 C CB  . ALA   A 1 228 ? 29.53578  -21.18771 36.54663  1.000 26.24101 ? 583  ALA   A CB  1 
ATOM   1727 N N   . MET   A 1 229 ? 29.32733  -19.52597 39.26066  1.000 18.78254 ? 584  MET   A N   1 
ATOM   1728 C CA  . MET   A 1 229 ? 29.77069  -19.20302 40.60808  1.000 16.47278 ? 584  MET   A CA  1 
ATOM   1729 C C   . MET   A 1 229 ? 28.65136  -19.41501 41.62405  1.000 16.60564 ? 584  MET   A C   1 
ATOM   1730 O O   . MET   A 1 229 ? 28.85492  -20.00134 42.69264  1.000 16.37200 ? 584  MET   A O   1 
ATOM   1731 C CB  . MET   A 1 229 ? 30.23644  -17.74243 40.62849  1.000 17.50790 ? 584  MET   A CB  1 
ATOM   1732 C CG  . MET   A 1 229 ? 30.57483  -17.20237 42.00433  1.000 19.21625 ? 584  MET   A CG  1 
ATOM   1733 S SD  . MET   A 1 229 ? 30.97468  -15.44209 41.86435  1.000 17.98730 ? 584  MET   A SD  1 
ATOM   1734 C CE  . MET   A 1 229 ? 31.32773  -15.08023 43.57985  1.000 22.52118 ? 584  MET   A CE  1 
ATOM   1735 N N   . LEU   A 1 230 ? 27.46213  -18.89558 41.32019  1.000 17.83970 ? 585  LEU   A N   1 
ATOM   1736 C CA  . LEU   A 1 230 ? 26.35708  -18.98302 42.27933  1.000 14.79424 ? 585  LEU   A CA  1 
ATOM   1737 C C   . LEU   A 1 230 ? 25.92868  -20.42181 42.46320  1.000 18.27120 ? 585  LEU   A C   1 
ATOM   1738 O O   . LEU   A 1 230 ? 25.59817  -20.80725 43.57765  1.000 16.86059 ? 585  LEU   A O   1 
ATOM   1739 C CB  . LEU   A 1 230 ? 25.16292  -18.14339 41.81218  1.000 17.43382 ? 585  LEU   A CB  1 
ATOM   1740 C CG  . LEU   A 1 230 ? 25.49674  -16.66443 41.79653  1.000 15.75661 ? 585  LEU   A CG  1 
ATOM   1741 C CD1 . LEU   A 1 230 ? 24.38823  -15.90949 41.02573  1.000 21.36708 ? 585  LEU   A CD1 1 
ATOM   1742 C CD2 . LEU   A 1 230 ? 25.71741  -16.06081 43.17397  1.000 14.66590 ? 585  LEU   A CD2 1 
ATOM   1743 N N   . GLU   A 1 231 ? 26.03089  -21.25088 41.39718  1.000 18.46982 ? 586  GLU   A N   1 
ATOM   1744 C CA  . GLU   A 1 231 ? 25.60482  -22.64138 41.51832  1.000 22.10381 ? 586  GLU   A CA  1 
ATOM   1745 C C   . GLU   A 1 231 ? 26.56793  -23.45735 42.37080  1.000 24.72524 ? 586  GLU   A C   1 
ATOM   1746 O O   . GLU   A 1 231 ? 26.14358  -24.45246 42.97722  1.000 28.19226 ? 586  GLU   A O   1 
ATOM   1747 C CB  . GLU   A 1 231 ? 25.47983  -23.26146 40.12720  1.000 23.00274 ? 586  GLU   A CB  1 
ATOM   1748 C CG  . GLU   A 1 231 ? 24.35943  -24.26107 40.01143  1.000 32.14103 ? 586  GLU   A CG  1 
ATOM   1749 C CD  . GLU   A 1 231 ? 24.00224  -24.54117 38.55330  1.000 35.48535 ? 586  GLU   A CD  1 
ATOM   1750 O OE1 . GLU   A 1 231 ? 23.18711  -23.76515 37.96356  1.000 30.81672 ? 586  GLU   A OE1 1 
ATOM   1751 O OE2 . GLU   A 1 231 ? 24.54925  -25.53443 38.02093  1.000 39.23270 ? 586  GLU   A OE2 1 
ATOM   1752 N N   . LYS   A 1 232 ? 27.85329  -23.07559 42.41943  1.000 19.87054 ? 587  LYS   A N   1 
ATOM   1753 C CA  . LYS   A 1 232 ? 28.84825  -23.59930 43.34493  1.000 20.05763 ? 587  LYS   A CA  1 
ATOM   1754 C C   . LYS   A 1 232 ? 28.59075  -23.16164 44.77354  1.000 20.48791 ? 587  LYS   A C   1 
ATOM   1755 O O   . LYS   A 1 232 ? 29.32419  -23.55656 45.68355  1.000 26.85200 ? 587  LYS   A O   1 
ATOM   1756 C CB  . LYS   A 1 232 ? 30.26504  -23.12482 42.97171  1.000 24.70859 ? 587  LYS   A CB  1 
ATOM   1757 C CG  . LYS   A 1 232 ? 30.82464  -23.68867 41.70317  1.000 28.48838 ? 587  LYS   A CG  1 
ATOM   1758 C CD  . LYS   A 1 232 ? 32.34390  -23.69951 41.80144  1.000 38.06578 ? 587  LYS   A CD  1 
ATOM   1759 C CE  . LYS   A 1 232 ? 32.95783  -22.55489 41.03633  1.000 40.43163 ? 587  LYS   A CE  1 
ATOM   1760 N NZ  . LYS   A 1 232 ? 32.95482  -22.85138 39.55862  1.000 50.73861 ? 587  LYS   A NZ  1 
ATOM   1761 N N   . GLY   A 1 233 ? 27.61239  -22.30141 45.01329  1.000 14.37542 ? 588  GLY   A N   1 
ATOM   1762 C CA  . GLY   A 1 233 ? 27.43225  -21.79376 46.35739  1.000 14.97091 ? 588  GLY   A CA  1 
ATOM   1763 C C   . GLY   A 1 233 ? 28.30113  -20.58914 46.71220  1.000 17.26824 ? 588  GLY   A C   1 
ATOM   1764 O O   . GLY   A 1 233 ? 28.22455  -20.10520 47.85373  1.000 17.95498 ? 588  GLY   A O   1 
ATOM   1765 N N   . GLU   A 1 234 ? 29.05165  -20.05273 45.76630  1.000 14.35961 ? 589  GLU   A N   1 
ATOM   1766 C CA  . GLU   A 1 234 ? 29.96675  -18.94539 46.05400  1.000 15.55079 ? 589  GLU   A CA  1 
ATOM   1767 C C   . GLU   A 1 234 ? 29.20908  -17.63210 45.93966  1.000 13.52649 ? 589  GLU   A C   1 
ATOM   1768 O O   . GLU   A 1 234 ? 28.25394  -17.51965 45.18841  1.000 13.37626 ? 589  GLU   A O   1 
ATOM   1769 C CB  . GLU   A 1 234 ? 31.15751  -18.94723 45.10361  1.000 16.83878 ? 589  GLU   A CB  1 
ATOM   1770 C CG  . GLU   A 1 234 ? 32.17535  -20.05451 45.44343  1.000 21.13059 ? 589  GLU   A CG  1 
ATOM   1771 C CD  . GLU   A 1 234 ? 33.22971  -20.19360 44.33794  1.000 30.58998 ? 589  GLU   A CD  1 
ATOM   1772 O OE1 . GLU   A 1 234 ? 33.39530  -19.26995 43.51328  1.000 30.09318 ? 589  GLU   A OE1 1 
ATOM   1773 O OE2 . GLU   A 1 234 ? 33.87495  -21.25499 44.27545  1.000 41.22798 ? 589  GLU   A OE2 1 
ATOM   1774 N N   . ARG   A 1 235 ? 29.65133  -16.64970 46.70807  1.000 13.08870 ? 590  ARG   A N   1 
ATOM   1775 C CA  . ARG   A 1 235 ? 29.05854  -15.31396 46.70724  1.000 11.40598 ? 590  ARG   A CA  1 
ATOM   1776 C C   . ARG   A 1 235 ? 30.17067  -14.30228 46.76627  1.000 13.82039 ? 590  ARG   A C   1 
ATOM   1777 O O   . ARG   A 1 235 ? 31.26118  -14.59543 47.28509  1.000 16.36966 ? 590  ARG   A O   1 
ATOM   1778 C CB  . ARG   A 1 235 ? 28.17539  -15.16598 47.94053  1.000 11.69117 ? 590  ARG   A CB  1 
ATOM   1779 C CG  . ARG   A 1 235 ? 26.96097  -16.16557 48.02429  1.000 14.56346 ? 590  ARG   A CG  1 
ATOM   1780 C CD  . ARG   A 1 235 ? 25.92139  -15.89977 46.93960  1.000 12.39361 ? 590  ARG   A CD  1 
ATOM   1781 N NE  . ARG   A 1 235 ? 24.73996  -16.77079 47.13568  1.000 13.54229 ? 590  ARG   A NE  1 
ATOM   1782 C CZ  . ARG   A 1 235 ? 24.61926  -17.97960 46.59223  1.000 13.90394 ? 590  ARG   A CZ  1 
ATOM   1783 N NH1 . ARG   A 1 235 ? 25.56470  -18.50591 45.83060  1.000 12.54437 ? 590  ARG   A NH1 1 
ATOM   1784 N NH2 . ARG   A 1 235 ? 23.47350  -18.65622 46.72674  1.000 14.60883 ? 590  ARG   A NH2 1 
ATOM   1785 N N   . MET   A 1 236 ? 29.86972  -13.09112 46.30733  1.000 14.05737 ? 591  MET   A N   1 
ATOM   1786 C CA  . MET   A 1 236 ? 30.85620  -12.00488 46.37080  1.000 13.58610 ? 591  MET   A CA  1 
ATOM   1787 C C   . MET   A 1 236 ? 31.32872  -11.79038 47.79907  1.000 14.80914 ? 591  MET   A C   1 
ATOM   1788 O O   . MET   A 1 236 ? 30.56144  -11.91151 48.74749  1.000 15.85163 ? 591  MET   A O   1 
ATOM   1789 C CB  . MET   A 1 236 ? 30.23414  -10.69027 45.85461  1.000 14.15665 ? 591  MET   A CB  1 
ATOM   1790 C CG  . MET   A 1 236 ? 30.02420  -10.72939 44.35435  1.000 12.81503 ? 591  MET   A CG  1 
ATOM   1791 S SD  . MET   A 1 236 ? 29.50876  -9.10818  43.68523  1.000 16.26835 ? 591  MET   A SD  1 
ATOM   1792 C CE  . MET   A 1 236 ? 27.84263  -9.09810  44.23004  1.000 15.77892 ? 591  MET   A CE  1 
ATOM   1793 N N   . GLY   A 1 237 ? 32.59475  -11.37152 47.90770  1.000 15.49605 ? 592  GLY   A N   1 
ATOM   1794 C CA  . GLY   A 1 237 ? 33.16062  -11.05582 49.20531  1.000 16.87686 ? 592  GLY   A CA  1 
ATOM   1795 C C   . GLY   A 1 237 ? 32.63205  -9.76562  49.79903  1.000 17.31425 ? 592  GLY   A C   1 
ATOM   1796 O O   . GLY   A 1 237 ? 31.96336  -8.94539  49.16391  1.000 17.71703 ? 592  GLY   A O   1 
ATOM   1797 N N   . CYS   A 1 238 ? 32.98699  -9.57510  51.05973  1.000 17.16911 ? 593  CYS   A N   1 
ATOM   1798 C CA  . CYS   A 1 238 ? 32.54959  -8.41318  51.82578  1.000 16.07063 ? 593  CYS   A CA  1 
ATOM   1799 C C   . CYS   A 1 238 ? 33.30521  -7.16459  51.39177  1.000 15.55040 ? 593  CYS   A C   1 
ATOM   1800 O O   . CYS   A 1 238 ? 34.55287  -7.18529  51.39354  1.000 17.35836 ? 593  CYS   A O   1 
ATOM   1801 C CB  . CYS   A 1 238 ? 32.81254  -8.70681  53.30721  1.000 17.98155 ? 593  CYS   A CB  1 
ATOM   1802 S SG  . CYS   A 1 238 ? 32.24625  -7.38483  54.37737  1.000 18.45425 ? 593  CYS   A SG  1 
ATOM   1803 N N   . PRO   A 1 239 ? 32.61936  -6.07733  50.98853  1.000 14.15649 ? 594  PRO   A N   1 
ATOM   1804 C CA  . PRO   A 1 239 ? 33.32564  -4.84066  50.59252  1.000 14.86848 ? 594  PRO   A CA  1 
ATOM   1805 C C   . PRO   A 1 239 ? 34.17565  -4.31159  51.73159  1.000 14.54299 ? 594  PRO   A C   1 
ATOM   1806 O O   . PRO   A 1 239 ? 33.81262  -4.43765  52.88957  1.000 17.08843 ? 594  PRO   A O   1 
ATOM   1807 C CB  . PRO   A 1 239 ? 32.18951  -3.85213  50.26704  1.000 14.29184 ? 594  PRO   A CB  1 
ATOM   1808 C CG  . PRO   A 1 239 ? 31.05288  -4.83411  49.84663  1.000 13.31421 ? 594  PRO   A CG  1 
ATOM   1809 C CD  . PRO   A 1 239 ? 31.15324  -5.98931  50.77734  1.000 15.77291 ? 594  PRO   A CD  1 
ATOM   1810 N N   . ALA   A 1 240 ? 35.26825  -3.65888  51.36636  1.000 16.64518 ? 595  ALA   A N   1 
ATOM   1811 C CA  . ALA   A 1 240 ? 36.06626  -2.94613  52.37303  1.000 19.46035 ? 595  ALA   A CA  1 
ATOM   1812 C C   . ALA   A 1 240 ? 35.21159  -2.00078  53.17978  1.000 20.03886 ? 595  ALA   A C   1 
ATOM   1813 O O   . ALA   A 1 240 ? 34.45535  -1.19414  52.62091  1.000 20.16488 ? 595  ALA   A O   1 
ATOM   1814 C CB  . ALA   A 1 240 ? 37.18107  -2.17236  51.67612  1.000 19.54203 ? 595  ALA   A CB  1 
ATOM   1815 N N   . GLY   A 1 241 ? 35.33851  -2.10878  54.50110  1.000 19.68157 ? 596  GLY   A N   1 
ATOM   1816 C CA  . GLY   A 1 241 ? 34.64942  -1.24243  55.44384  1.000 21.32031 ? 596  GLY   A CA  1 
ATOM   1817 C C   . GLY   A 1 241 ? 33.19388  -1.56196  55.66891  1.000 22.00707 ? 596  GLY   A C   1 
ATOM   1818 O O   . GLY   A 1 241 ? 32.52223  -0.82738  56.40979  1.000 23.65470 ? 596  GLY   A O   1 
ATOM   1819 N N   . CYS   A 1 242 ? 32.67818  -2.64236  55.05954  1.000 16.86768 ? 597  CYS   A N   1 
ATOM   1820 C CA  . CYS   A 1 242 ? 31.28780  -2.99084  55.24409  1.000 19.23437 ? 597  CYS   A CA  1 
ATOM   1821 C C   . CYS   A 1 242 ? 31.10549  -3.75206  56.56018  1.000 17.59214 ? 597  CYS   A C   1 
ATOM   1822 O O   . CYS   A 1 242 ? 31.78054  -4.77148  56.79035  1.000 18.55100 ? 597  CYS   A O   1 
ATOM   1823 C CB  . CYS   A 1 242 ? 30.79659  -3.83047  54.04400  1.000 16.73543 ? 597  CYS   A CB  1 
ATOM   1824 S SG  . CYS   A 1 242 ? 29.12164  -4.31966  54.15356  1.000 17.89618 ? 597  CYS   A SG  1 
ATOM   1825 N N   . PRO   A 1 243 ? 30.17006  -3.32746  57.41357  1.000 17.98573 ? 598  PRO   A N   1 
ATOM   1826 C CA  . PRO   A 1 243 ? 29.91863  -4.05153  58.66212  1.000 18.33260 ? 598  PRO   A CA  1 
ATOM   1827 C C   . PRO   A 1 243 ? 29.54083  -5.49545  58.41282  1.000 20.35883 ? 598  PRO   A C   1 
ATOM   1828 O O   . PRO   A 1 243 ? 28.82118  -5.81939  57.46768  1.000 18.13242 ? 598  PRO   A O   1 
ATOM   1829 C CB  . PRO   A 1 243 ? 28.75660  -3.27372  59.28100  1.000 22.68305 ? 598  PRO   A CB  1 
ATOM   1830 C CG  . PRO   A 1 243 ? 28.89151  -1.88939  58.71272  1.000 22.81046 ? 598  PRO   A CG  1 
ATOM   1831 C CD  . PRO   A 1 243 ? 29.37067  -2.08596  57.30326  1.000 18.88320 ? 598  PRO   A CD  1 
ATOM   1832 N N   . ARG   A 1 244 ? 30.00802  -6.37037  59.30179  1.000 18.05926 ? 599  ARG   A N   1 
ATOM   1833 C CA  . ARG   A 1 244 ? 29.65131  -7.78106  59.19886  1.000 18.39783 ? 599  ARG   A CA  1 
ATOM   1834 C C   . ARG   A 1 244 ? 28.13954  -8.00271  59.16151  1.000 16.73613 ? 599  ARG   A C   1 
ATOM   1835 O O   . ARG   A 1 244 ? 27.66114  -8.85475  58.39888  1.000 18.78150 ? 599  ARG   A O   1 
ATOM   1836 C CB  . ARG   A 1 244 ? 30.31533  -8.52137  60.36797  1.000 23.39747 ? 599  ARG   A CB  1 
ATOM   1837 C CG  . ARG   A 1 244 ? 31.69280  -9.02773  59.94897  1.000 41.29320 ? 599  ARG   A CG  1 
ATOM   1838 C CD  . ARG   A 1 244 ? 31.54127  -10.08238 58.82142  1.000 43.44360 ? 599  ARG   A CD  1 
ATOM   1839 N NE  . ARG   A 1 244 ? 32.53026  -9.96418  57.75503  1.000 43.73273 ? 599  ARG   A NE  1 
ATOM   1840 C CZ  . ARG   A 1 244 ? 32.82499  -10.93954 56.90359  1.000 44.93192 ? 599  ARG   A CZ  1 
ATOM   1841 N NH1 . ARG   A 1 244 ? 32.16993  -12.09076 56.92086  1.000 47.20999 ? 599  ARG   A NH1 1 
ATOM   1842 N NH2 . ARG   A 1 244 ? 33.81105  -10.76270 56.02410  1.000 43.09750 ? 599  ARG   A NH2 1 
ATOM   1843 N N   . GLU   A 1 245 ? 27.37563  -7.20722  59.91881  1.000 18.06162 ? 600  GLU   A N   1 
ATOM   1844 C CA  . GLU   A 1 245 ? 25.93262  -7.37879  59.94940  1.000 18.70943 ? 600  GLU   A CA  1 
ATOM   1845 C C   . GLU   A 1 245 ? 25.32136  -7.08932  58.58335  1.000 19.02047 ? 600  GLU   A C   1 
ATOM   1846 O O   . GLU   A 1 245 ? 24.33070  -7.72826  58.18509  1.000 18.61070 ? 600  GLU   A O   1 
ATOM   1847 C CB  . GLU   A 1 245 ? 25.30521  -6.44175  60.99056  1.000 19.63271 ? 600  GLU   A CB  1 
ATOM   1848 C CG  . GLU   A 1 245 ? 25.75662  -6.71674  62.45966  1.000 26.77270 ? 600  GLU   A CG  1 
ATOM   1849 C CD  . GLU   A 1 245 ? 27.08233  -6.07515  62.89273  1.000 28.23712 ? 600  GLU   A CD  1 
ATOM   1850 O OE1 . GLU   A 1 245 ? 27.89282  -5.58492  62.06140  1.000 24.48954 ? 600  GLU   A OE1 1 
ATOM   1851 O OE2 . GLU   A 1 245 ? 27.32373  -6.07073  64.12674  1.000 42.89069 ? 600  GLU   A OE2 1 
ATOM   1852 N N   . MET   A 1 246 ? 25.89656  -6.12918  57.86932  1.000 17.43302 ? 601  MET   A N   1 
ATOM   1853 C CA  . MET   A 1 246 ? 25.38951  -5.79798  56.53846  1.000 15.01888 ? 601  MET   A CA  1 
ATOM   1854 C C   . MET   A 1 246 ? 25.81087  -6.83297  55.50379  1.000 17.72291 ? 601  MET   A C   1 
ATOM   1855 O O   . MET   A 1 246 ? 25.01264  -7.17979  54.61498  1.000 14.76136 ? 601  MET   A O   1 
ATOM   1856 C CB  . MET   A 1 246 ? 25.84165  -4.39451  56.16203  1.000 13.51236 ? 601  MET   A CB  1 
ATOM   1857 C CG  . MET   A 1 246 ? 25.25543  -3.30727  57.12975  1.000 13.43644 ? 601  MET   A CG  1 
ATOM   1858 S SD  . MET   A 1 246 ? 23.49162  -3.07781  56.82140  1.000 18.90904 ? 601  MET   A SD  1 
ATOM   1859 C CE  . MET   A 1 246 ? 22.81339  -4.22692  58.00289  1.000 19.95628 ? 601  MET   A CE  1 
ATOM   1860 N N   . TYR   A 1 247 ? 26.99569  -7.41768  55.64683  1.000 15.29416 ? 602  TYR   A N   1 
ATOM   1861 C CA  . TYR   A 1 247 ? 27.36122  -8.51428  54.75914  1.000 15.96425 ? 602  TYR   A CA  1 
ATOM   1862 C C   . TYR   A 1 247 ? 26.50099  -9.72458  55.03045  1.000 15.25504 ? 602  TYR   A C   1 
ATOM   1863 O O   . TYR   A 1 247 ? 26.12666  -10.45462 54.10630  1.000 15.14310 ? 602  TYR   A O   1 
ATOM   1864 C CB  . TYR   A 1 247 ? 28.83334  -8.85157  54.94765  1.000 14.48426 ? 602  TYR   A CB  1 
ATOM   1865 C CG  . TYR   A 1 247 ? 29.33865  -9.84903  53.96348  1.000 14.31545 ? 602  TYR   A CG  1 
ATOM   1866 C CD1 . TYR   A 1 247 ? 29.26988  -9.60769  52.60797  1.000 15.13773 ? 602  TYR   A CD1 1 
ATOM   1867 C CD2 . TYR   A 1 247 ? 30.04130  -10.96642 54.39587  1.000 18.49766 ? 602  TYR   A CD2 1 
ATOM   1868 C CE1 . TYR   A 1 247 ? 29.74732  -10.49898 51.70002  1.000 16.60398 ? 602  TYR   A CE1 1 
ATOM   1869 C CE2 . TYR   A 1 247 ? 30.56306  -11.85592 53.49383  1.000 18.11661 ? 602  TYR   A CE2 1 
ATOM   1870 C CZ  . TYR   A 1 247 ? 30.41626  -11.61828 52.16572  1.000 18.45536 ? 602  TYR   A CZ  1 
ATOM   1871 O OH  . TYR   A 1 247 ? 30.98350  -12.51598 51.30717  1.000 17.92959 ? 602  TYR   A OH  1 
ATOM   1872 N N   . ASP   A 1 248 ? 26.20895  -9.97897  56.31151  1.000 14.17863 ? 603  ASP   A N   1 
ATOM   1873 C CA  . ASP   A 1 248 ? 25.30891  -11.06567 56.64946  1.000 15.60648 ? 603  ASP   A CA  1 
ATOM   1874 C C   . ASP   A 1 248 ? 23.96306  -10.88291 55.96467  1.000 14.54387 ? 603  ASP   A C   1 
ATOM   1875 O O   . ASP   A 1 248 ? 23.40708  -11.83243 55.43396  1.000 14.75777 ? 603  ASP   A O   1 
ATOM   1876 C CB  . ASP   A 1 248 ? 25.10587  -11.16186 58.18102  1.000 16.04792 ? 603  ASP   A CB  1 
ATOM   1877 C CG  . ASP   A 1 248 ? 26.37621  -11.57914 58.89806  1.000 25.58740 ? 603  ASP   A CG  1 
ATOM   1878 O OD1 . ASP   A 1 248 ? 27.32375  -12.05523 58.22840  1.000 24.20057 ? 603  ASP   A OD1 1 
ATOM   1879 O OD2 . ASP   A 1 248 ? 26.42927  -11.39100 60.13260  1.000 30.56293 ? 603  ASP   A OD2 1 
ATOM   1880 N N   . LEU   A 1 249 ? 23.42659  -9.66110  55.97436  1.000 14.49015 ? 604  LEU   A N   1 
ATOM   1881 C CA  . LEU   A 1 249 ? 22.13892  -9.39895  55.34486  1.000 15.20979 ? 604  LEU   A CA  1 
ATOM   1882 C C   . LEU   A 1 249 ? 22.22147  -9.56176  53.82789  1.000 14.93132 ? 604  LEU   A C   1 
ATOM   1883 O O   . LEU   A 1 249 ? 21.30957  -10.12448 53.22499  1.000 13.70783 ? 604  LEU   A O   1 
ATOM   1884 C CB  . LEU   A 1 249 ? 21.66628  -7.99225  55.72468  1.000 16.08849 ? 604  LEU   A CB  1 
ATOM   1885 C CG  . LEU   A 1 249 ? 20.32842  -7.58376  55.08556  1.000 15.52038 ? 604  LEU   A CG  1 
ATOM   1886 C CD1 . LEU   A 1 249 ? 19.24097  -8.54914  55.48536  1.000 16.49970 ? 604  LEU   A CD1 1 
ATOM   1887 C CD2 . LEU   A 1 249 ? 19.97873  -6.10485  55.50070  1.000 17.19223 ? 604  LEU   A CD2 1 
ATOM   1888 N N   . MET   A 1 250 ? 23.31894  -9.12168  53.20411  1.000 13.07518 ? 605  MET   A N   1 
ATOM   1889 C CA  . MET   A 1 250 ? 23.52356  -9.36445  51.77244  1.000 11.96132 ? 605  MET   A CA  1 
ATOM   1890 C C   . MET   A 1 250 ? 23.42938  -10.83420 51.48587  1.000 13.91634 ? 605  MET   A C   1 
ATOM   1891 O O   . MET   A 1 250 ? 22.73579  -11.27942 50.56279  1.000 13.83328 ? 605  MET   A O   1 
ATOM   1892 C CB  . MET   A 1 250 ? 24.92926  -8.92084  51.30780  1.000 15.24727 ? 605  MET   A CB  1 
ATOM   1893 C CG  . MET   A 1 250 ? 25.04412  -7.48321  51.08281  1.000 19.57708 ? 605  MET   A CG  1 
ATOM   1894 S SD  . MET   A 1 250 ? 26.82536  -7.18248  50.72347  1.000 17.71396 ? 605  MET   A SD  1 
ATOM   1895 C CE  . MET   A 1 250 ? 26.84184  -5.58769  51.49689  1.000 20.01496 ? 605  MET   A CE  1 
ATOM   1896 N N   . ASN   A 1 251 ? 24.09496  -11.63505 52.31685  1.000 14.14521 ? 606  ASN   A N   1 
ATOM   1897 C CA  . ASN   A 1 251 ? 24.11319  -13.07340 52.05741  1.000 13.44446 ? 606  ASN   A CA  1 
ATOM   1898 C C   . ASN   A 1 251 ? 22.75443  -13.72055 52.28813  1.000 13.06011 ? 606  ASN   A C   1 
ATOM   1899 O O   . ASN   A 1 251 ? 22.40708  -14.69860 51.59451  1.000 15.85890 ? 606  ASN   A O   1 
ATOM   1900 C CB  . ASN   A 1 251 ? 25.20793  -13.77378 52.89703  1.000 14.50498 ? 606  ASN   A CB  1 
ATOM   1901 C CG  . ASN   A 1 251 ? 26.50638  -13.72002 52.22216  1.000 19.37869 ? 606  ASN   A CG  1 
ATOM   1902 O OD1 . ASN   A 1 251 ? 27.39476  -12.89786 52.57915  1.000 29.77194 ? 606  ASN   A OD1 1 
ATOM   1903 N ND2 . ASN   A 1 251 ? 26.65090  -14.51168 51.19205  1.000 13.68201 ? 606  ASN   A ND2 1 
ATOM   1904 N N   . LEU   A 1 252 ? 21.96195  -13.19703 53.22828  1.000 12.12214 ? 607  LEU   A N   1 
ATOM   1905 C CA  . LEU   A 1 252 ? 20.58663  -13.67902 53.39384  1.000 14.56890 ? 607  LEU   A CA  1 
ATOM   1906 C C   . LEU   A 1 252 ? 19.73537  -13.33539 52.16340  1.000 13.45828 ? 607  LEU   A C   1 
ATOM   1907 O O   . LEU   A 1 252 ? 18.88886  -14.12794 51.72561  1.000 14.18643 ? 607  LEU   A O   1 
ATOM   1908 C CB  . LEU   A 1 252 ? 19.98480  -13.11133 54.69148  1.000 19.01802 ? 607  LEU   A CB  1 
ATOM   1909 C CG  . LEU   A 1 252 ? 18.57017  -13.54709 55.03411  1.000 19.97803 ? 607  LEU   A CG  1 
ATOM   1910 C CD1 . LEU   A 1 252 ? 18.55641  -15.03551 55.36841  1.000 22.16107 ? 607  LEU   A CD1 1 
ATOM   1911 C CD2 . LEU   A 1 252 ? 18.13323  -12.71807 56.22739  1.000 20.03043 ? 607  LEU   A CD2 1 
ATOM   1912 N N   . CYS   A 1 253 ? 19.94917  -12.13711 51.58276  1.000 13.03098 ? 608  CYS   A N   1 
ATOM   1913 C CA  . CYS   A 1 253 ? 19.22726  -11.80859 50.34830  1.000 12.73742 ? 608  CYS   A CA  1 
ATOM   1914 C C   . CYS   A 1 253 ? 19.61471  -12.76140 49.24020  1.000 14.54007 ? 608  CYS   A C   1 
ATOM   1915 O O   . CYS   A 1 253 ? 18.77976  -13.05758 48.37742  1.000 14.32169 ? 608  CYS   A O   1 
ATOM   1916 C CB  . CYS   A 1 253 ? 19.51002  -10.36795 49.92034  1.000 12.39179 ? 608  CYS   A CB  1 
ATOM   1917 S SG  . CYS   A 1 253 ? 18.89016  -9.09977  51.01331  1.000 14.94468 ? 608  CYS   A SG  1 
ATOM   1918 N N   . TRP   A 1 254 ? 20.86913  -13.26376 49.25493  1.000 12.70207 ? 609  TRP   A N   1 
ATOM   1919 C CA  . TRP   A 1 254 ? 21.33404  -14.22392 48.23919  1.000 12.81621 ? 609  TRP   A CA  1 
ATOM   1920 C C   . TRP   A 1 254 ? 21.09059  -15.66121 48.64906  1.000 12.05720 ? 609  TRP   A C   1 
ATOM   1921 O O   . TRP   A 1 254 ? 21.86334  -16.55328 48.29727  1.000 12.53705 ? 609  TRP   A O   1 
ATOM   1922 C CB  . TRP   A 1 254 ? 22.82395  -14.01711 47.93466  1.000 12.94374 ? 609  TRP   A CB  1 
ATOM   1923 C CG  . TRP   A 1 254 ? 23.15913  -12.62272 47.46921  1.000 10.43903 ? 609  TRP   A CG  1 
ATOM   1924 C CD1 . TRP   A 1 254 ? 22.39087  -11.76959 46.72314  1.000 12.08973 ? 609  TRP   A CD1 1 
ATOM   1925 C CD2 . TRP   A 1 254 ? 24.39147  -11.96117 47.71942  1.000 10.34917 ? 609  TRP   A CD2 1 
ATOM   1926 N NE1 . TRP   A 1 254 ? 23.09874  -10.59719 46.49833  1.000 11.39915 ? 609  TRP   A NE1 1 
ATOM   1927 C CE2 . TRP   A 1 254 ? 24.33888  -10.71583 47.09575  1.000 9.87531  ? 609  TRP   A CE2 1 
ATOM   1928 C CE3 . TRP   A 1 254 ? 25.56524  -12.31974 48.42838  1.000 11.00155 ? 609  TRP   A CE3 1 
ATOM   1929 C CZ2 . TRP   A 1 254 ? 25.40460  -9.78708  47.15217  1.000 12.76304 ? 609  TRP   A CZ2 1 
ATOM   1930 C CZ3 . TRP   A 1 254 ? 26.62366  -11.38319 48.46203  1.000 12.60952 ? 609  TRP   A CZ3 1 
ATOM   1931 C CH2 . TRP   A 1 254 ? 26.53265  -10.16287 47.83191  1.000 14.08843 ? 609  TRP   A CH2 1 
ATOM   1932 N N   . THR   A 1 255 ? 19.96741  -15.89928 49.30575  1.000 14.00450 ? 610  THR   A N   1 
ATOM   1933 C CA  . THR   A 1 255 ? 19.53965  -17.26663 49.59451  1.000 14.24469 ? 610  THR   A CA  1 
ATOM   1934 C C   . THR   A 1 255 ? 19.05984  -17.91164 48.29597  1.000 13.90542 ? 610  THR   A C   1 
ATOM   1935 O O   . THR   A 1 255 ? 18.21753  -17.35796 47.58468  1.000 14.96007 ? 610  THR   A O   1 
ATOM   1936 C CB  . THR   A 1 255 ? 18.43117  -17.23953 50.61632  1.000 13.35542 ? 610  THR   A CB  1 
ATOM   1937 O OG1 . THR   A 1 255 ? 18.91957  -16.78924 51.88374  1.000 16.79510 ? 610  THR   A OG1 1 
ATOM   1938 C CG2 . THR   A 1 255 ? 17.80537  -18.61531 50.80940  1.000 15.89951 ? 610  THR   A CG2 1 
ATOM   1939 N N   . TYR   A 1 256 ? 19.63470  -19.05868 47.93739  1.000 14.53668 ? 611  TYR   A N   1 
ATOM   1940 C CA  . TYR   A 1 256 ? 19.36059  -19.66247 46.63815  1.000 13.02989 ? 611  TYR   A CA  1 
ATOM   1941 C C   . TYR   A 1 256 ? 17.88673  -20.03913 46.48103  1.000 13.74734 ? 611  TYR   A C   1 
ATOM   1942 O O   . TYR   A 1 256 ? 17.25541  -19.73464 45.45180  1.000 16.34676 ? 611  TYR   A O   1 
ATOM   1943 C CB  . TYR   A 1 256 ? 20.24729  -20.90441 46.46903  1.000 15.23606 ? 611  TYR   A CB  1 
ATOM   1944 C CG  . TYR   A 1 256 ? 20.22753  -21.46333 45.09445  1.000 12.77870 ? 611  TYR   A CG  1 
ATOM   1945 C CD1 . TYR   A 1 256 ? 19.23194  -22.36670 44.73017  1.000 15.01246 ? 611  TYR   A CD1 1 
ATOM   1946 C CD2 . TYR   A 1 256 ? 21.18316  -21.11660 44.14155  1.000 13.20941 ? 611  TYR   A CD2 1 
ATOM   1947 C CE1 . TYR   A 1 256 ? 19.17624  -22.90464 43.44452  1.000 16.10843 ? 611  TYR   A CE1 1 
ATOM   1948 C CE2 . TYR   A 1 256 ? 21.12315  -21.63103 42.82482  1.000 17.14361 ? 611  TYR   A CE2 1 
ATOM   1949 C CZ  . TYR   A 1 256 ? 20.11636  -22.54276 42.49747  1.000 16.26045 ? 611  TYR   A CZ  1 
ATOM   1950 O OH  . TYR   A 1 256 ? 20.06129  -23.05220 41.21021  1.000 20.02948 ? 611  TYR   A OH  1 
ATOM   1951 N N   . ASP   A 1 257 ? 17.34505  -20.75662 47.44321  1.000 15.77577 ? 612  ASP   A N   1 
ATOM   1952 C CA  . ASP   A 1 257 ? 15.95154  -21.22657 47.35203  1.000 14.83577 ? 612  ASP   A CA  1 
ATOM   1953 C C   . ASP   A 1 257 ? 14.98782  -20.08505 47.69227  1.000 15.33828 ? 612  ASP   A C   1 
ATOM   1954 O O   . ASP   A 1 257 ? 14.97558  -19.57179 48.82071  1.000 16.63652 ? 612  ASP   A O   1 
ATOM   1955 C CB  . ASP   A 1 257 ? 15.72190  -22.38571 48.31534  1.000 16.73217 ? 612  ASP   A CB  1 
ATOM   1956 C CG  . ASP   A 1 257 ? 16.65231  -23.55979 48.07859  1.000 16.15973 ? 612  ASP   A CG  1 
ATOM   1957 O OD1 . ASP   A 1 257 ? 17.07327  -23.82586 46.94685  1.000 17.89381 ? 612  ASP   A OD1 1 
ATOM   1958 O OD2 . ASP   A 1 257 ? 16.94265  -24.25146 49.11667  1.000 19.19449 ? 612  ASP   A OD2 1 
ATOM   1959 N N   . VAL   A 1 258 ? 14.16870  -19.71040 46.70493  1.000 20.55914 ? 613  VAL   A N   1 
ATOM   1960 C CA  . VAL   A 1 258 ? 13.28998  -18.54730 46.87929  1.000 19.93523 ? 613  VAL   A CA  1 
ATOM   1961 C C   . VAL   A 1 258 ? 12.37350  -18.72213 48.08653  1.000 18.72953 ? 613  VAL   A C   1 
ATOM   1962 O O   . VAL   A 1 258 ? 12.14641  -17.77836 48.84663  1.000 18.97104 ? 613  VAL   A O   1 
ATOM   1963 C CB  . VAL   A 1 258 ? 12.52733  -18.29055 45.55963  1.000 19.30639 ? 613  VAL   A CB  1 
ATOM   1964 C CG1 . VAL   A 1 258 ? 11.58134  -19.45047 45.14215  1.000 21.59377 ? 613  VAL   A CG1 1 
ATOM   1965 C CG2 . VAL   A 1 258 ? 11.82290  -16.96260 45.59229  1.000 23.63632 ? 613  VAL   A CG2 1 
ATOM   1966 N N   . GLU   A 1 259 ? 11.89546  -19.95264 48.34163  1.000 21.74759 ? 614  GLU   A N   1 
ATOM   1967 C CA  . GLU   A 1 259 ? 11.01432  -20.09643 49.49455  1.000 24.69919 ? 614  GLU   A CA  1 
ATOM   1968 C C   . GLU   A 1 259 ? 11.68838  -19.81768 50.82834  1.000 22.20357 ? 614  GLU   A C   1 
ATOM   1969 O O   . GLU   A 1 259 ? 11.00378  -19.46528 51.79537  1.000 24.81487 ? 614  GLU   A O   1 
ATOM   1970 C CB  . GLU   A 1 259 ? 10.37542  -21.49235 49.50087  1.000 24.69708 ? 614  GLU   A CB  1 
ATOM   1971 C CG  . GLU   A 1 259 ? 9.42720   -21.68817 48.33235  1.000 40.67391 ? 614  GLU   A CG  1 
ATOM   1972 C CD  . GLU   A 1 259 ? 8.37369   -20.58208 48.24711  1.000 48.06647 ? 614  GLU   A CD  1 
ATOM   1973 O OE1 . GLU   A 1 259 ? 7.94889   -20.07972 49.31544  1.000 55.07470 ? 614  GLU   A OE1 1 
ATOM   1974 O OE2 . GLU   A 1 259 ? 7.97956   -20.20743 47.11424  1.000 50.93219 ? 614  GLU   A OE2 1 
ATOM   1975 N N   . ASN   A 1 260 ? 13.01514  -19.92797 50.91576  1.000 18.07314 ? 615  ASN   A N   1 
ATOM   1976 C CA  . ASN   A 1 260 ? 13.73027  -19.66479 52.15489  1.000 19.26505 ? 615  ASN   A CA  1 
ATOM   1977 C C   . ASN   A 1 260 ? 14.36319  -18.28481 52.19887  1.000 18.74695 ? 615  ASN   A C   1 
ATOM   1978 O O   . ASN   A 1 260 ? 14.96910  -17.90545 53.21269  1.000 20.29639 ? 615  ASN   A O   1 
ATOM   1979 C CB  . ASN   A 1 260 ? 14.79657  -20.72503 52.35617  1.000 21.76131 ? 615  ASN   A CB  1 
ATOM   1980 C CG  . ASN   A 1 260 ? 14.21044  -22.14076 52.32997  1.000 28.17271 ? 615  ASN   A CG  1 
ATOM   1981 O OD1 . ASN   A 1 260 ? 13.04718  -22.35569 52.70519  1.000 28.60469 ? 615  ASN   A OD1 1 
ATOM   1982 N ND2 . ASN   A 1 260 ? 14.99164  -23.09526 51.84333  1.000 24.58067 ? 615  ASN   A ND2 1 
ATOM   1983 N N   . ARG   A 1 261 ? 14.18752  -17.51313 51.17632  1.000 16.14336 ? 616  ARG   A N   1 
ATOM   1984 C CA  . ARG   A 1 261 ? 14.74697  -16.15705 51.14745  1.000 14.61371 ? 616  ARG   A CA  1 
ATOM   1985 C C   . ARG   A 1 261 ? 13.79096  -15.19397 51.85222  1.000 15.71044 ? 616  ARG   A C   1 
ATOM   1986 O O   . ARG   A 1 261 ? 12.56996  -15.33808 51.74112  1.000 17.10827 ? 616  ARG   A O   1 
ATOM   1987 C CB  . ARG   A 1 261 ? 14.93413  -15.76136 49.68872  1.000 13.63555 ? 616  ARG   A CB  1 
ATOM   1988 C CG  . ARG   A 1 261 ? 15.66917  -14.43880 49.44067  1.000 13.31905 ? 616  ARG   A CG  1 
ATOM   1989 C CD  . ARG   A 1 261 ? 15.74495  -14.14722 47.92301  1.000 13.74636 ? 616  ARG   A CD  1 
ATOM   1990 N NE  . ARG   A 1 261 ? 16.27334  -15.28038 47.15920  1.000 12.93637 ? 616  ARG   A NE  1 
ATOM   1991 C CZ  . ARG   A 1 261 ? 15.84389  -15.63602 45.95934  1.000 14.12302 ? 616  ARG   A CZ  1 
ATOM   1992 N NH1 . ARG   A 1 261 ? 14.96109  -14.87523 45.29356  1.000 13.42093 ? 616  ARG   A NH1 1 
ATOM   1993 N NH2 . ARG   A 1 261 ? 16.31350  -16.75925 45.39509  1.000 14.85872 ? 616  ARG   A NH2 1 
ATOM   1994 N N   . PRO   A 1 262 ? 14.26783  -14.20403 52.58409  1.000 13.56261 ? 617  PRO   A N   1 
ATOM   1995 C CA  . PRO   A 1 262 ? 13.32462  -13.28598 53.24371  1.000 16.79104 ? 617  PRO   A CA  1 
ATOM   1996 C C   . PRO   A 1 262 ? 12.60640  -12.37556 52.23747  1.000 18.74466 ? 617  PRO   A C   1 
ATOM   1997 O O   . PRO   A 1 262 ? 13.10098  -12.09790 51.13269  1.000 17.13504 ? 617  PRO   A O   1 
ATOM   1998 C CB  . PRO   A 1 262 ? 14.21308  -12.44716 54.16260  1.000 19.85038 ? 617  PRO   A CB  1 
ATOM   1999 C CG  . PRO   A 1 262 ? 15.51897  -12.45267 53.43787  1.000 17.97588 ? 617  PRO   A CG  1 
ATOM   2000 C CD  . PRO   A 1 262 ? 15.66880  -13.82097 52.82878  1.000 17.02944 ? 617  PRO   A CD  1 
ATOM   2001 N N   . GLY   A 1 263 ? 11.41288  -11.89512 52.63632  1.000 20.10523 ? 618  GLY   A N   1 
ATOM   2002 C CA  . GLY   A 1 263 ? 10.75220  -10.80048 51.94962  1.000 17.67979 ? 618  GLY   A CA  1 
ATOM   2003 C C   . GLY   A 1 263 ? 11.23512  -9.44366  52.45999  1.000 14.39040 ? 618  GLY   A C   1 
ATOM   2004 O O   . GLY   A 1 263 ? 12.04217  -9.33946  53.39260  1.000 16.24356 ? 618  GLY   A O   1 
ATOM   2005 N N   . PHE   A 1 264 ? 10.74856  -8.37146  51.80740  1.000 14.19639 ? 619  PHE   A N   1 
ATOM   2006 C CA  . PHE   A 1 264 ? 11.21770  -7.03781  52.15634  1.000 13.74394 ? 619  PHE   A CA  1 
ATOM   2007 C C   . PHE   A 1 264 ? 10.78353  -6.57435  53.53764  1.000 16.08421 ? 619  PHE   A C   1 
ATOM   2008 O O   . PHE   A 1 264 ? 11.50351  -5.78772  54.14006  1.000 17.20481 ? 619  PHE   A O   1 
ATOM   2009 C CB  . PHE   A 1 264 ? 10.82986  -5.96291  51.13028  1.000 15.28689 ? 619  PHE   A CB  1 
ATOM   2010 C CG  . PHE   A 1 264 ? 11.72390  -5.96113  49.95344  1.000 15.18112 ? 619  PHE   A CG  1 
ATOM   2011 C CD1 . PHE   A 1 264 ? 13.02443  -5.54721  50.08468  1.000 12.58935 ? 619  PHE   A CD1 1 
ATOM   2012 C CD2 . PHE   A 1 264 ? 11.27461  -6.48765  48.73405  1.000 12.72381 ? 619  PHE   A CD2 1 
ATOM   2013 C CE1 . PHE   A 1 264 ? 13.85515  -5.56664  48.93119  1.000 12.37281 ? 619  PHE   A CE1 1 
ATOM   2014 C CE2 . PHE   A 1 264 ? 12.11572  -6.51700  47.57292  1.000 12.13072 ? 619  PHE   A CE2 1 
ATOM   2015 C CZ  . PHE   A 1 264 ? 13.41645  -6.05866  47.71254  1.000 13.86146 ? 619  PHE   A CZ  1 
ATOM   2016 N N   . ALA   A 1 265 ? 9.66873   -7.08583  54.08954  1.000 17.86642 ? 620  ALA   A N   1 
ATOM   2017 C CA  . ALA   A 1 265 ? 9.34967   -6.70657  55.46338  1.000 20.52529 ? 620  ALA   A CA  1 
ATOM   2018 C C   . ALA   A 1 265 ? 10.45560  -7.12497  56.42475  1.000 19.13465 ? 620  ALA   A C   1 
ATOM   2019 O O   . ALA   A 1 265 ? 10.90457  -6.31682  57.25256  1.000 21.16030 ? 620  ALA   A O   1 
ATOM   2020 C CB  . ALA   A 1 265 ? 8.00284   -7.32198  55.86416  1.000 20.06241 ? 620  ALA   A CB  1 
ATOM   2021 N N   . ALA   A 1 266 ? 10.93683  -8.37113  56.29744  1.000 16.37440 ? 621  ALA   A N   1 
ATOM   2022 C CA  . ALA   A 1 266 ? 12.04095  -8.82202  57.14130  1.000 17.70768 ? 621  ALA   A CA  1 
ATOM   2023 C C   . ALA   A 1 266 ? 13.33924  -8.06536  56.84184  1.000 18.53368 ? 621  ALA   A C   1 
ATOM   2024 O O   . ALA   A 1 266 ? 14.10866  -7.73120  57.76108  1.000 19.55276 ? 621  ALA   A O   1 
ATOM   2025 C CB  . ALA   A 1 266 ? 12.21445  -10.32862 56.97286  1.000 20.57105 ? 621  ALA   A CB  1 
ATOM   2026 N N   . VAL   A 1 267 ? 13.61271  -7.77716  55.55744  1.000 17.03873 ? 622  VAL   A N   1 
ATOM   2027 C CA  . VAL   A 1 267 ? 14.85844  -7.09143  55.21073  1.000 16.52877 ? 622  VAL   A CA  1 
ATOM   2028 C C   . VAL   A 1 267 ? 14.85036  -5.66305  55.73676  1.000 16.16671 ? 622  VAL   A C   1 
ATOM   2029 O O   . VAL   A 1 267 ? 15.84513  -5.19234  56.30317  1.000 17.51990 ? 622  VAL   A O   1 
ATOM   2030 C CB  . VAL   A 1 267 ? 15.07258  -7.13120  53.67910  1.000 14.99568 ? 622  VAL   A CB  1 
ATOM   2031 C CG1 . VAL   A 1 267 ? 16.24259  -6.21883  53.19694  1.000 16.96521 ? 622  VAL   A CG1 1 
ATOM   2032 C CG2 . VAL   A 1 267 ? 15.32415  -8.56079  53.19255  1.000 14.57220 ? 622  VAL   A CG2 1 
ATOM   2033 N N   . GLU   A 1 268 ? 13.73177  -4.94302  55.53608  1.000 14.57982 ? 623  GLU   A N   1 
ATOM   2034 C CA  . GLU   A 1 268 ? 13.64497  -3.56839  56.00984  1.000 15.05923 ? 623  GLU   A CA  1 
ATOM   2035 C C   . GLU   A 1 268 ? 13.79574  -3.49834  57.52661  1.000 16.20790 ? 623  GLU   A C   1 
ATOM   2036 O O   . GLU   A 1 268 ? 14.47331  -2.61212  58.04208  1.000 17.90044 ? 623  GLU   A O   1 
ATOM   2037 C CB  . GLU   A 1 268 ? 12.33208  -2.92615  55.55421  1.000 18.55585 ? 623  GLU   A CB  1 
ATOM   2038 C CG  . GLU   A 1 268 ? 12.18786  -1.42841  55.92191  1.000 17.42320 ? 623  GLU   A CG  1 
ATOM   2039 C CD  . GLU   A 1 268 ? 11.72673  -1.13415  57.37096  1.000 21.33088 ? 623  GLU   A CD  1 
ATOM   2040 O OE1 . GLU   A 1 268 ? 10.99844  -1.99333  57.92517  1.000 23.37350 ? 623  GLU   A OE1 1 
ATOM   2041 O OE2 . GLU   A 1 268 ? 12.09600  -0.05911  57.89673  1.000 20.11349 ? 623  GLU   A OE2 1 
ATOM   2042 N N   . LEU   A 1 269 ? 13.19956  -4.44651  58.23791  1.000 19.18428 ? 624  LEU   A N   1 
ATOM   2043 C CA  . LEU   A 1 269 ? 13.30157  -4.42873  59.70181  1.000 21.72687 ? 624  LEU   A CA  1 
ATOM   2044 C C   . LEU   A 1 269 ? 14.73349  -4.64546  60.15329  1.000 19.90837 ? 624  LEU   A C   1 
ATOM   2045 O O   . LEU   A 1 269 ? 15.23752  -3.95506  61.04638  1.000 19.55944 ? 624  LEU   A O   1 
ATOM   2046 C CB  . LEU   A 1 269 ? 12.36746  -5.49477  60.26877  1.000 20.52899 ? 624  LEU   A CB  1 
ATOM   2047 C CG  . LEU   A 1 269 ? 12.33611  -5.57249  61.80376  1.000 24.25933 ? 624  LEU   A CG  1 
ATOM   2048 C CD1 . LEU   A 1 269 ? 11.96209  -4.23121  62.43492  1.000 24.55296 ? 624  LEU   A CD1 1 
ATOM   2049 C CD2 . LEU   A 1 269 ? 11.40995  -6.70256  62.22822  1.000 26.89542 ? 624  LEU   A CD2 1 
ATOM   2050 N N   . ARG   A 1 270 ? 15.44073  -5.56891  59.50968  1.000 17.59914 ? 625  ARG   A N   1 
ATOM   2051 C CA  . ARG   A 1 270 ? 16.82895  -5.77456  59.89816  1.000 18.74774 ? 625  ARG   A CA  1 
ATOM   2052 C C   . ARG   A 1 270 ? 17.65112  -4.52454  59.65970  1.000 19.63403 ? 625  ARG   A C   1 
ATOM   2053 O O   . ARG   A 1 270 ? 18.48795  -4.14418  60.48878  1.000 19.14823 ? 625  ARG   A O   1 
ATOM   2054 C CB  . ARG   A 1 270 ? 17.43693  -6.94167  59.10741  1.000 17.76323 ? 625  ARG   A CB  1 
ATOM   2055 C CG  . ARG   A 1 270 ? 18.88890  -7.07587  59.40136  1.000 25.88971 ? 625  ARG   A CG  1 
ATOM   2056 C CD  . ARG   A 1 270 ? 19.09422  -7.91622  60.64766  1.000 36.56629 ? 625  ARG   A CD  1 
ATOM   2057 N NE  . ARG   A 1 270 ? 20.41008  -7.69432  61.23369  1.000 44.10820 ? 625  ARG   A NE  1 
ATOM   2058 C CZ  . ARG   A 1 270 ? 20.69958  -6.76169  62.13740  1.000 44.35488 ? 625  ARG   A CZ  1 
ATOM   2059 N NH1 . ARG   A 1 270 ? 19.77131  -5.91926  62.60948  1.000 30.46024 ? 625  ARG   A NH1 1 
ATOM   2060 N NH2 . ARG   A 1 270 ? 21.95259  -6.66450  62.57911  1.000 40.63589 ? 625  ARG   A NH2 1 
ATOM   2061 N N   . LEU   A 1 271 ? 17.45253  -3.87120  58.50920  1.000 18.11320 ? 626  LEU   A N   1 
ATOM   2062 C CA  . LEU   A 1 271 ? 18.17957  -2.64232  58.21448  1.000 17.99310 ? 626  LEU   A CA  1 
ATOM   2063 C C   . LEU   A 1 271 ? 17.78677  -1.51094  59.16075  1.000 16.86657 ? 626  LEU   A C   1 
ATOM   2064 O O   . LEU   A 1 271 ? 18.62783  -0.68533  59.51922  1.000 19.24486 ? 626  LEU   A O   1 
ATOM   2065 C CB  . LEU   A 1 271 ? 17.88707  -2.22328  56.77272  1.000 19.13756 ? 626  LEU   A CB  1 
ATOM   2066 C CG  . LEU   A 1 271 ? 18.90352  -2.80116  55.81680  1.000 15.88548 ? 626  LEU   A CG  1 
ATOM   2067 C CD1 . LEU   A 1 271 ? 18.28729  -2.68789  54.41324  1.000 14.56038 ? 626  LEU   A CD1 1 
ATOM   2068 C CD2 . LEU   A 1 271 ? 20.25110  -2.11276  55.87049  1.000 19.70398 ? 626  LEU   A CD2 1 
ATOM   2069 N N   . ARG   A 1 272 ? 16.49754  -1.43932  59.50732  1.000 17.48865 ? 627  ARG   A N   1 
ATOM   2070 C CA  . ARG   A 1 272 ? 16.01346  -0.37059  60.37939  1.000 19.58875 ? 627  ARG   A CA  1 
ATOM   2071 C C   . ARG   A 1 272 ? 16.67952  -0.50104  61.73117  1.000 20.16491 ? 627  ARG   A C   1 
ATOM   2072 O O   . ARG   A 1 272 ? 17.23695  0.45865   62.25410  1.000 21.80493 ? 627  ARG   A O   1 
ATOM   2073 C CB  . ARG   A 1 272 ? 14.50212  -0.47314  60.51175  1.000 21.94192 ? 627  ARG   A CB  1 
ATOM   2074 C CG  . ARG   A 1 272 ? 13.90162  0.70180   61.31331  1.000 26.59992 ? 627  ARG   A CG  1 
ATOM   2075 C CD  . ARG   A 1 272 ? 12.60066  0.27528   61.93160  1.000 29.31579 ? 627  ARG   A CD  1 
ATOM   2076 N NE  . ARG   A 1 272 ? 11.72018  -0.38980  60.98322  1.000 31.30265 ? 627  ARG   A NE  1 
ATOM   2077 C CZ  . ARG   A 1 272 ? 10.59955  -1.02236  61.31722  1.000 34.57017 ? 627  ARG   A CZ  1 
ATOM   2078 N NH1 . ARG   A 1 272 ? 10.16253  -1.04626  62.56892  1.000 39.05495 ? 627  ARG   A NH1 1 
ATOM   2079 N NH2 . ARG   A 1 272 ? 9.90176   -1.65245  60.37578  1.000 31.29625 ? 627  ARG   A NH2 1 
ATOM   2080 N N   . ASN   A 1 273 ? 16.68210  -1.71694  62.26277  1.000 18.68967 ? 628  ASN   A N   1 
ATOM   2081 C CA  . ASN   A 1 273 ? 17.25023  -1.94209  63.58430  1.000 23.88814 ? 628  ASN   A CA  1 
ATOM   2082 C C   . ASN   A 1 273 ? 18.74404  -1.66919  63.57911  1.000 25.30605 ? 628  ASN   A C   1 
ATOM   2083 O O   . ASN   A 1 273 ? 19.26986  -1.04823  64.50649  1.000 24.08708 ? 628  ASN   A O   1 
ATOM   2084 C CB  . ASN   A 1 273 ? 16.97390  -3.37773  64.03689  1.000 22.04243 ? 628  ASN   A CB  1 
ATOM   2085 C CG  . ASN   A 1 273 ? 15.53412  -3.58257  64.47136  1.000 19.38042 ? 628  ASN   A CG  1 
ATOM   2086 O OD1 . ASN   A 1 273 ? 14.83446  -2.59947  64.74238  1.000 26.86394 ? 628  ASN   A OD1 1 
ATOM   2087 N ND2 . ASN   A 1 273 ? 15.06325  -4.81614  64.46559  1.000 23.84845 ? 628  ASN   A ND2 1 
ATOM   2088 N N   . TYR   A 1 274 ? 19.45291  -2.09736  62.52748  1.000 20.84438 ? 629  TYR   A N   1 
ATOM   2089 C CA  . TYR   A 1 274 ? 20.89009  -1.86432  62.51316  1.000 18.04546 ? 629  TYR   A CA  1 
ATOM   2090 C C   . TYR   A 1 274 ? 21.20383  -0.38116  62.37973  1.000 23.60855 ? 629  TYR   A C   1 
ATOM   2091 O O   . TYR   A 1 274 ? 22.12081  0.13412   63.02941  1.000 23.09757 ? 629  TYR   A O   1 
ATOM   2092 C CB  . TYR   A 1 274 ? 21.57412  -2.67711  61.37201  1.000 20.44589 ? 629  TYR   A CB  1 
ATOM   2093 C CG  . TYR   A 1 274 ? 23.07717  -2.61856  61.53082  1.000 20.59174 ? 629  TYR   A CG  1 
ATOM   2094 C CD1 . TYR   A 1 274 ? 23.69805  -3.24698  62.61163  1.000 19.64315 ? 629  TYR   A CD1 1 
ATOM   2095 C CD2 . TYR   A 1 274 ? 23.89019  -1.95485  60.64235  1.000 22.72359 ? 629  TYR   A CD2 1 
ATOM   2096 C CE1 . TYR   A 1 274 ? 25.04120  -3.19582  62.78733  1.000 21.02094 ? 629  TYR   A CE1 1 
ATOM   2097 C CE2 . TYR   A 1 274 ? 25.26667  -1.86783  60.84165  1.000 24.15702 ? 629  TYR   A CE2 1 
ATOM   2098 C CZ  . TYR   A 1 274 ? 25.83770  -2.51735  61.92617  1.000 20.16836 ? 629  TYR   A CZ  1 
ATOM   2099 O OH  . TYR   A 1 274 ? 27.18652  -2.45183  62.12610  1.000 27.33888 ? 629  TYR   A OH  1 
ATOM   2100 N N   . TYR   A 1 275 ? 20.47251  0.31946   61.52273  1.000 19.32731 ? 630  TYR   A N   1 
ATOM   2101 C CA  . TYR   A 1 275 ? 20.69360  1.73688   61.37034  1.000 18.74630 ? 630  TYR   A CA  1 
ATOM   2102 C C   . TYR   A 1 275 ? 20.50255  2.46999   62.69761  1.000 20.64308 ? 630  TYR   A C   1 
ATOM   2103 O O   . TYR   A 1 275 ? 21.32662  3.30753   63.05710  1.000 20.79638 ? 630  TYR   A O   1 
ATOM   2104 C CB  . TYR   A 1 275 ? 19.75327  2.28364   60.29618  1.000 21.93729 ? 630  TYR   A CB  1 
ATOM   2105 C CG  . TYR   A 1 275 ? 19.91973  3.74235   60.08848  1.000 19.77567 ? 630  TYR   A CG  1 
ATOM   2106 C CD1 . TYR   A 1 275 ? 21.14889  4.28073   59.69639  1.000 19.46518 ? 630  TYR   A CD1 1 
ATOM   2107 C CD2 . TYR   A 1 275 ? 18.83825  4.60365   60.24443  1.000 23.43627 ? 630  TYR   A CD2 1 
ATOM   2108 C CE1 . TYR   A 1 275 ? 21.31347  5.63545   59.51329  1.000 21.57611 ? 630  TYR   A CE1 1 
ATOM   2109 C CE2 . TYR   A 1 275 ? 18.99601  5.98299   60.06375  1.000 23.24388 ? 630  TYR   A CE2 1 
ATOM   2110 C CZ  . TYR   A 1 275 ? 20.23227  6.47461   59.67489  1.000 22.08259 ? 630  TYR   A CZ  1 
ATOM   2111 O OH  . TYR   A 1 275 ? 20.43846  7.82095   59.48319  1.000 26.81985 ? 630  TYR   A OH  1 
ATOM   2112 N N   . TYR   A 1 276 ? 19.44405  2.13761   63.44178  1.000 21.62280 ? 631  TYR   A N   1 
ATOM   2113 C CA  . TYR   A 1 276 ? 19.23755  2.92012   64.66197  1.000 24.09121 ? 631  TYR   A CA  1 
ATOM   2114 C C   . TYR   A 1 276 ? 20.24677  2.50869   65.74674  1.000 32.78012 ? 631  TYR   A C   1 
ATOM   2115 O O   . TYR   A 1 276 ? 20.61380  3.34415   66.59384  1.000 27.79491 ? 631  TYR   A O   1 
ATOM   2116 C CB  . TYR   A 1 276 ? 17.73409  2.85035   65.01581  1.000 28.34603 ? 631  TYR   A CB  1 
ATOM   2117 C CG  . TYR   A 1 276 ? 16.93691  3.74745   64.02566  1.000 23.82042 ? 631  TYR   A CG  1 
ATOM   2118 C CD1 . TYR   A 1 276 ? 17.33777  5.07841   63.80519  1.000 33.94919 ? 631  TYR   A CD1 1 
ATOM   2119 C CD2 . TYR   A 1 276 ? 15.83850  3.28877   63.32251  1.000 27.14991 ? 631  TYR   A CD2 1 
ATOM   2120 C CE1 . TYR   A 1 276 ? 16.65781  5.92345   62.91929  1.000 37.57227 ? 631  TYR   A CE1 1 
ATOM   2121 C CE2 . TYR   A 1 276 ? 15.16658  4.11564   62.42551  1.000 29.28025 ? 631  TYR   A CE2 1 
ATOM   2122 C CZ  . TYR   A 1 276 ? 15.57691  5.43393   62.22208  1.000 33.33176 ? 631  TYR   A CZ  1 
ATOM   2123 O OH  . TYR   A 1 276 ? 14.91017  6.27869   61.32918  1.000 35.31212 ? 631  TYR   A OH  1 
ATOM   2124 N N   . ASP   A 1 277 ? 20.82673  1.30449   65.63976  1.000 27.35635 ? 632  ASP   A N   1 
ATOM   2125 C CA  . ASP   A 1 277 ? 21.97928  0.93483   66.46363  1.000 29.73485 ? 632  ASP   A CA  1 
ATOM   2126 C C   . ASP   A 1 277 ? 23.18612  1.81662   66.17047  1.000 31.23409 ? 632  ASP   A C   1 
ATOM   2127 O O   . ASP   A 1 277 ? 23.88998  2.25705   67.08504  1.000 37.64439 ? 632  ASP   A O   1 
ATOM   2128 C CB  . ASP   A 1 277 ? 22.35646  -0.52902  66.22994  1.000 25.07228 ? 632  ASP   A CB  1 
ATOM   2129 C CG  . ASP   A 1 277 ? 21.39721  -1.49045  66.87191  1.000 38.63977 ? 632  ASP   A CG  1 
ATOM   2130 O OD1 . ASP   A 1 277 ? 20.54151  -1.04088  67.66539  1.000 43.78591 ? 632  ASP   A OD1 1 
ATOM   2131 O OD2 . ASP   A 1 277 ? 21.50154  -2.70497  66.57523  1.000 49.29803 ? 632  ASP   A OD2 1 
ATOM   2132 N N   . VAL   A 1 278 ? 23.47837  2.04158   64.89175  1.000 24.28981 ? 633  VAL   A N   1 
ATOM   2133 C CA  . VAL   A 1 278 ? 24.61801  2.85255   64.50981  1.000 30.01825 ? 633  VAL   A CA  1 
ATOM   2134 C C   . VAL   A 1 278 ? 24.33823  4.32312   64.77714  1.000 34.23131 ? 633  VAL   A C   1 
ATOM   2135 O O   . VAL   A 1 278 ? 25.24708  5.07744   65.12974  1.000 48.52845 ? 633  VAL   A O   1 
ATOM   2136 C CB  . VAL   A 1 278 ? 24.95539  2.59636   63.02834  1.000 30.49210 ? 633  VAL   A CB  1 
ATOM   2137 C CG1 . VAL   A 1 278 ? 25.97594  3.59220   62.53423  1.000 35.85841 ? 633  VAL   A CG1 1 
ATOM   2138 C CG2 . VAL   A 1 278 ? 25.46039  1.18184   62.85403  1.000 29.46426 ? 633  VAL   A CG2 1 
ATOM   2139 N N   . VAL   A 1 279 ? 23.08991  4.75120   64.62386  1.000 31.11710 ? 634  VAL   A N   1 
ATOM   2140 C CA  . VAL   A 1 279 ? 22.69171  6.12086   64.98003  1.000 36.41812 ? 634  VAL   A CA  1 
ATOM   2141 C C   . VAL   A 1 279 ? 22.92598  6.36968   66.47569  1.000 40.88383 ? 634  VAL   A C   1 
ATOM   2142 O O   . VAL   A 1 279 ? 23.53924  7.36848   66.85021  1.000 41.53238 ? 634  VAL   A O   1 
ATOM   2143 C CB  . VAL   A 1 279 ? 21.22127  6.39278   64.59187  1.000 30.13697 ? 634  VAL   A CB  1 
ATOM   2144 C CG1 . VAL   A 1 279 ? 20.68647  7.63576   65.29803  1.000 34.93136 ? 634  VAL   A CG1 1 
ATOM   2145 C CG2 . VAL   A 1 279 ? 21.13247  6.59233   63.10548  1.000 35.26500 ? 634  VAL   A CG2 1 
ATOM   2146 N N   . TYR   B 1 9   ? -21.62271 -33.90719 13.96930  1.000 35.08262 ? 364  TYR   B N   1 
ATOM   2147 C CA  . TYR   B 1 9   ? -21.05514 -34.62871 15.11606  1.000 29.04312 ? 364  TYR   B CA  1 
ATOM   2148 C C   . TYR   B 1 9   ? -20.83651 -36.09464 14.82595  1.000 30.90435 ? 364  TYR   B C   1 
ATOM   2149 O O   . TYR   B 1 9   ? -21.78699 -36.82819 14.51711  1.000 36.78149 ? 364  TYR   B O   1 
ATOM   2150 C CB  . TYR   B 1 9   ? -21.94592 -34.47800 16.33193  1.000 36.46873 ? 364  TYR   B CB  1 
ATOM   2151 C CG  . TYR   B 1 9   ? -21.56363 -33.26999 17.15293  1.000 38.46485 ? 364  TYR   B CG  1 
ATOM   2152 C CD1 . TYR   B 1 9   ? -21.91825 -31.99724 16.74530  1.000 40.90018 ? 364  TYR   B CD1 1 
ATOM   2153 C CD2 . TYR   B 1 9   ? -20.81750 -33.40432 18.31436  1.000 40.20517 ? 364  TYR   B CD2 1 
ATOM   2154 C CE1 . TYR   B 1 9   ? -21.56570 -30.87873 17.49002  1.000 50.85516 ? 364  TYR   B CE1 1 
ATOM   2155 C CE2 . TYR   B 1 9   ? -20.46150 -32.29941 19.06937  1.000 53.24895 ? 364  TYR   B CE2 1 
ATOM   2156 C CZ  . TYR   B 1 9   ? -20.83829 -31.03807 18.64983  1.000 55.90184 ? 364  TYR   B CZ  1 
ATOM   2157 O OH  . TYR   B 1 9   ? -20.48632 -29.93235 19.38785  1.000 60.65135 ? 364  TYR   B OH  1 
ATOM   2158 N N   . LEU   B 1 10  ? -19.58646 -36.52072 14.95168  1.000 23.67914 ? 365  LEU   B N   1 
ATOM   2159 C CA  . LEU   B 1 10  ? -19.18149 -37.86576 14.58894  1.000 22.81868 ? 365  LEU   B CA  1 
ATOM   2160 C C   . LEU   B 1 10  ? -19.24507 -38.79170 15.78767  1.000 28.52646 ? 365  LEU   B C   1 
ATOM   2161 O O   . LEU   B 1 10  ? -19.19475 -38.36927 16.94906  1.000 26.29594 ? 365  LEU   B O   1 
ATOM   2162 C CB  . LEU   B 1 10  ? -17.76107 -37.86156 14.04601  1.000 21.08565 ? 365  LEU   B CB  1 
ATOM   2163 C CG  . LEU   B 1 10  ? -17.56255 -36.83475 12.93596  1.000 21.21573 ? 365  LEU   B CG  1 
ATOM   2164 C CD1 . LEU   B 1 10  ? -16.09940 -36.80289 12.58570  1.000 19.97676 ? 365  LEU   B CD1 1 
ATOM   2165 C CD2 . LEU   B 1 10  ? -18.37183 -37.29873 11.76603  1.000 24.20033 ? 365  LEU   B CD2 1 
ATOM   2166 N N   . ASP   B 1 11  ? -19.28178 -40.07747 15.48213  1.000 24.43784 ? 366  ASP   B N   1 
ATOM   2167 C CA  . ASP   B 1 11  ? -19.35906 -41.13418 16.48539  1.000 23.67416 ? 366  ASP   B CA  1 
ATOM   2168 C C   . ASP   B 1 11  ? -17.94456 -41.53203 16.89288  1.000 31.39866 ? 366  ASP   B C   1 
ATOM   2169 O O   . ASP   B 1 11  ? -17.16501 -42.03699 16.07633  1.000 26.82958 ? 366  ASP   B O   1 
ATOM   2170 C CB  . ASP   B 1 11  ? -20.13875 -42.29840 15.87436  1.000 28.17971 ? 366  ASP   B CB  1 
ATOM   2171 C CG  . ASP   B 1 11  ? -20.34024 -43.45592 16.83796  1.000 36.67588 ? 366  ASP   B CG  1 
ATOM   2172 O OD1 . ASP   B 1 11  ? -19.75483 -43.45279 17.95278  1.000 31.14460 ? 366  ASP   B OD1 1 
ATOM   2173 O OD2 . ASP   B 1 11  ? -21.07701 -44.37956 16.43921  1.000 38.08531 ? 366  ASP   B OD2 1 
ATOM   2174 N N   . ARG   B 1 12  ? -17.58818 -41.30162 18.15171  1.000 26.23601 ? 367  ARG   B N   1 
ATOM   2175 C CA  . ARG   B 1 12  ? -16.22058 -41.59688 18.55612  1.000 21.82093 ? 367  ARG   B CA  1 
ATOM   2176 C C   . ARG   B 1 12  ? -15.85693 -43.05321 18.33179  1.000 26.34586 ? 367  ARG   B C   1 
ATOM   2177 O O   . ARG   B 1 12  ? -14.66832 -43.37161 18.18077  1.000 27.77473 ? 367  ARG   B O   1 
ATOM   2178 C CB  . ARG   B 1 12  ? -15.99882 -41.21314 20.03415  1.000 27.66734 ? 367  ARG   B CB  1 
ATOM   2179 C CG  . ARG   B 1 12  ? -14.56769 -41.46853 20.59994  1.000 26.27992 ? 367  ARG   B CG  1 
ATOM   2180 C CD  . ARG   B 1 12  ? -13.50301 -40.63043 19.92129  1.000 29.59367 ? 367  ARG   B CD  1 
ATOM   2181 N NE  . ARG   B 1 12  ? -12.18039 -40.82666 20.51072  1.000 24.71874 ? 367  ARG   B NE  1 
ATOM   2182 C CZ  . ARG   B 1 12  ? -11.31703 -41.74137 20.09582  1.000 27.33933 ? 367  ARG   B CZ  1 
ATOM   2183 N NH1 . ARG   B 1 12  ? -11.60698 -42.55568 19.08972  1.000 29.28590 ? 367  ARG   B NH1 1 
ATOM   2184 N NH2 . ARG   B 1 12  ? -10.13740 -41.84311 20.69931  1.000 35.15421 ? 367  ARG   B NH2 1 
ATOM   2185 N N   . LYS   B 1 13  ? -16.84486 -43.95475 18.36615  1.000 27.29850 ? 368  LYS   B N   1 
ATOM   2186 C CA  . LYS   B 1 13  ? -16.52531 -45.36829 18.22047  1.000 25.98427 ? 368  LYS   B CA  1 
ATOM   2187 C C   . LYS   B 1 13  ? -16.19707 -45.72050 16.78116  1.000 29.25977 ? 368  LYS   B C   1 
ATOM   2188 O O   . LYS   B 1 13  ? -15.64358 -46.79446 16.53583  1.000 28.86965 ? 368  LYS   B O   1 
ATOM   2189 C CB  . LYS   B 1 13  ? -17.67490 -46.23588 18.72896  1.000 41.48462 ? 368  LYS   B CB  1 
ATOM   2190 C CG  . LYS   B 1 13  ? -18.79898 -46.38986 17.74341  1.000 39.50657 ? 368  LYS   B CG  1 
ATOM   2191 C CD  . LYS   B 1 13  ? -19.83514 -47.40932 18.24883  1.000 55.99569 ? 368  LYS   B CD  1 
ATOM   2192 C CE  . LYS   B 1 13  ? -21.18697 -46.78134 18.56909  1.000 43.56649 ? 368  LYS   B CE  1 
ATOM   2193 N NZ  . LYS   B 1 13  ? -21.07352 -45.79061 19.65966  1.000 43.63527 ? 368  LYS   B NZ  1 
ATOM   2194 N N   . LEU   B 1 14  ? -16.48429 -44.82311 15.83963  1.000 22.73785 ? 369  LEU   B N   1 
ATOM   2195 C CA  . LEU   B 1 14  ? -16.12827 -45.02292 14.43374  1.000 23.18033 ? 369  LEU   B CA  1 
ATOM   2196 C C   . LEU   B 1 14  ? -14.77779 -44.40413 14.09813  1.000 21.86428 ? 369  LEU   B C   1 
ATOM   2197 O O   . LEU   B 1 14  ? -14.27475 -44.58266 12.97775  1.000 22.51156 ? 369  LEU   B O   1 
ATOM   2198 C CB  . LEU   B 1 14  ? -17.21970 -44.44498 13.54580  1.000 23.83210 ? 369  LEU   B CB  1 
ATOM   2199 C CG  . LEU   B 1 14  ? -18.59984 -45.14323 13.57279  1.000 25.02070 ? 369  LEU   B CG  1 
ATOM   2200 C CD1 . LEU   B 1 14  ? -19.51182 -44.48420 12.57927  1.000 25.96642 ? 369  LEU   B CD1 1 
ATOM   2201 C CD2 . LEU   B 1 14  ? -18.44393 -46.61090 13.24776  1.000 30.58310 ? 369  LEU   B CD2 1 
ATOM   2202 N N   . LEU   B 1 15  ? -14.16493 -43.72267 15.05382  1.000 21.10653 ? 370  LEU   B N   1 
ATOM   2203 C CA  . LEU   B 1 15  ? -12.88806 -43.03203 14.88587  1.000 21.48866 ? 370  LEU   B CA  1 
ATOM   2204 C C   . LEU   B 1 15  ? -11.78385 -43.80690 15.59560  1.000 24.72200 ? 370  LEU   B C   1 
ATOM   2205 O O   . LEU   B 1 15  ? -11.91180 -44.14044 16.78194  1.000 24.22837 ? 370  LEU   B O   1 
ATOM   2206 C CB  . LEU   B 1 15  ? -12.97739 -41.59578 15.43354  1.000 21.15574 ? 370  LEU   B CB  1 
ATOM   2207 C CG  . LEU   B 1 15  ? -11.71482 -40.72847 15.32696  1.000 28.19353 ? 370  LEU   B CG  1 
ATOM   2208 C CD1 . LEU   B 1 15  ? -11.36539 -40.47598 13.82029  1.000 23.26688 ? 370  LEU   B CD1 1 
ATOM   2209 C CD2 . LEU   B 1 15  ? -11.99384 -39.40448 16.06396  1.000 27.38936 ? 370  LEU   B CD2 1 
ATOM   2210 N N   . THR   B 1 16  ? -10.69226 -44.09108 14.88277  1.000 22.99377 ? 371  THR   B N   1 
ATOM   2211 C CA  . THR   B 1 16  ? -9.50443  -44.72024 15.44813  1.000 24.39323 ? 371  THR   B CA  1 
ATOM   2212 C C   . THR   B 1 16  ? -8.31829  -43.78146 15.30170  1.000 26.88726 ? 371  THR   B C   1 
ATOM   2213 O O   . THR   B 1 16  ? -7.89445  -43.49718 14.17874  1.000 28.91315 ? 371  THR   B O   1 
ATOM   2214 C CB  . THR   B 1 16  ? -9.19302  -46.04517 14.74280  1.000 26.14274 ? 371  THR   B CB  1 
ATOM   2215 O OG1 . THR   B 1 16  ? -10.36371 -46.88668 14.72874  1.000 30.00279 ? 371  THR   B OG1 1 
ATOM   2216 C CG2 . THR   B 1 16  ? -8.06670  -46.74666 15.42383  1.000 29.56745 ? 371  THR   B CG2 1 
ATOM   2217 N N   . LEU   B 1 17  ? -7.76966  -43.31214 16.41746  1.000 26.16948 ? 372  LEU   B N   1 
ATOM   2218 C CA  . LEU   B 1 17  ? -6.59817  -42.43263 16.40814  1.000 21.21952 ? 372  LEU   B CA  1 
ATOM   2219 C C   . LEU   B 1 17  ? -5.28542  -43.19085 16.53136  1.000 27.21987 ? 372  LEU   B C   1 
ATOM   2220 O O   . LEU   B 1 17  ? -5.16881  -44.12910 17.32673  1.000 30.68634 ? 372  LEU   B O   1 
ATOM   2221 C CB  . LEU   B 1 17  ? -6.67958  -41.40303 17.54258  1.000 27.53904 ? 372  LEU   B CB  1 
ATOM   2222 C CG  . LEU   B 1 17  ? -7.82941  -40.40523 17.47256  1.000 28.94160 ? 372  LEU   B CG  1 
ATOM   2223 C CD1 . LEU   B 1 17  ? -7.82907  -39.50000 18.68576  1.000 32.16774 ? 372  LEU   B CD1 1 
ATOM   2224 C CD2 . LEU   B 1 17  ? -7.70197  -39.57872 16.19019  1.000 28.73717 ? 372  LEU   B CD2 1 
ATOM   2225 N N   . GLU   B 1 18  ? -4.27776  -42.77471 15.76203  1.000 22.21701 ? 373  GLU   B N   1 
ATOM   2226 C CA  . GLU   B 1 18  ? -2.94821  -43.32156 15.97435  1.000 24.07534 ? 373  GLU   B CA  1 
ATOM   2227 C C   . GLU   B 1 18  ? -2.31106  -42.65883 17.19234  1.000 33.20097 ? 373  GLU   B C   1 
ATOM   2228 O O   . GLU   B 1 18  ? -2.64944  -41.53478 17.56070  1.000 36.68765 ? 373  GLU   B O   1 
ATOM   2229 C CB  . GLU   B 1 18  ? -2.06219  -43.12018 14.75533  1.000 26.28893 ? 373  GLU   B CB  1 
ATOM   2230 C CG  . GLU   B 1 18  ? -2.64914  -43.68493 13.48374  1.000 33.23919 ? 373  GLU   B CG  1 
ATOM   2231 C CD  . GLU   B 1 18  ? -3.22301  -45.09488 13.66746  1.000 49.21930 ? 373  GLU   B CD  1 
ATOM   2232 O OE1 . GLU   B 1 18  ? -2.50242  -45.95919 14.21777  1.000 49.26661 ? 373  GLU   B OE1 1 
ATOM   2233 O OE2 . GLU   B 1 18  ? -4.39689  -45.33778 13.26922  1.000 36.13575 ? 373  GLU   B OE2 1 
ATOM   2234 N N   . ASP   B 1 19  ? -1.39174  -43.36555 17.83434  1.000 37.71378 ? 374  ASP   B N   1 
ATOM   2235 C CA  . ASP   B 1 19  ? -0.85688  -42.82258 19.07955  1.000 36.62398 ? 374  ASP   B CA  1 
ATOM   2236 C C   . ASP   B 1 19  ? 0.12591   -41.68249 18.83938  1.000 34.05011 ? 374  ASP   B C   1 
ATOM   2237 O O   . ASP   B 1 19  ? 0.12772   -40.69514 19.58122  1.000 37.24595 ? 374  ASP   B O   1 
ATOM   2238 C CB  . ASP   B 1 19  ? -0.20613  -43.93065 19.89992  1.000 41.00598 ? 374  ASP   B CB  1 
ATOM   2239 C CG  . ASP   B 1 19  ? -1.22839  -44.76039 20.66651  1.000 59.61100 ? 374  ASP   B CG  1 
ATOM   2240 O OD1 . ASP   B 1 19  ? -2.11048  -44.15589 21.32055  1.000 56.51636 ? 374  ASP   B OD1 1 
ATOM   2241 O OD2 . ASP   B 1 19  ? -1.15692  -46.01048 20.60650  1.000 64.63941 ? 374  ASP   B OD2 1 
ATOM   2242 N N   . LYS   B 1 20  ? 0.95578   -41.77866 17.81651  1.000 32.21605 ? 375  LYS   B N   1 
ATOM   2243 C CA  . LYS   B 1 20  ? 2.00778   -40.79714 17.63163  1.000 34.20557 ? 375  LYS   B CA  1 
ATOM   2244 C C   . LYS   B 1 20  ? 1.44484   -39.61514 16.86398  1.000 32.74771 ? 375  LYS   B C   1 
ATOM   2245 O O   . LYS   B 1 20  ? 0.67022   -39.79032 15.92555  1.000 36.66051 ? 375  LYS   B O   1 
ATOM   2246 C CB  . LYS   B 1 20  ? 3.19994   -41.40123 16.89221  1.000 39.60860 ? 375  LYS   B CB  1 
ATOM   2247 C CG  . LYS   B 1 20  ? 4.41440   -40.48822 16.79804  1.000 50.62258 ? 375  LYS   B CG  1 
ATOM   2248 C CD  . LYS   B 1 20  ? 4.84693   -39.96029 18.16781  1.000 60.50698 ? 375  LYS   B CD  1 
ATOM   2249 C CE  . LYS   B 1 20  ? 6.36654   -39.92087 18.30360  1.000 68.21118 ? 375  LYS   B CE  1 
ATOM   2250 N NZ  . LYS   B 1 20  ? 6.92334   -41.20508 18.82512  1.000 76.26116 ? 375  LYS   B NZ  1 
ATOM   2251 N N   . GLU   B 1 21  ? 1.82252   -38.41174 17.27496  1.000 28.48492 ? 376  GLU   B N   1 
ATOM   2252 C CA  . GLU   B 1 21  ? 1.25355   -37.24008 16.62171  1.000 28.55091 ? 376  GLU   B CA  1 
ATOM   2253 C C   . GLU   B 1 21  ? 2.01821   -36.90270 15.35098  1.000 28.55871 ? 376  GLU   B C   1 
ATOM   2254 O O   . GLU   B 1 21  ? 3.22807   -37.14435 15.23951  1.000 30.06291 ? 376  GLU   B O   1 
ATOM   2255 C CB  . GLU   B 1 21  ? 1.24547   -36.04702 17.57700  1.000 32.14098 ? 376  GLU   B CB  1 
ATOM   2256 C CG  . GLU   B 1 21  ? 2.61221   -35.51394 17.87521  1.000 37.77007 ? 376  GLU   B CG  1 
ATOM   2257 C CD  . GLU   B 1 21  ? 2.60362   -34.57978 19.06328  1.000 50.28814 ? 376  GLU   B CD  1 
ATOM   2258 O OE1 . GLU   B 1 21  ? 1.75292   -34.78254 19.96038  1.000 46.76678 ? 376  GLU   B OE1 1 
ATOM   2259 O OE2 . GLU   B 1 21  ? 3.44366   -33.65318 19.09202  1.000 49.85769 ? 376  GLU   B OE2 1 
ATOM   2260 N N   . LEU   B 1 22  ? 1.28831   -36.36203 14.36203  1.000 21.97653 ? 377  LEU   B N   1 
ATOM   2261 C CA  . LEU   B 1 22  ? 1.94831   -35.82374 13.18166  1.000 23.95598 ? 377  LEU   B CA  1 
ATOM   2262 C C   . LEU   B 1 22  ? 2.62452   -34.50509 13.48222  1.000 24.79987 ? 377  LEU   B C   1 
ATOM   2263 O O   . LEU   B 1 22  ? 3.66472   -34.18797 12.87975  1.000 27.05823 ? 377  LEU   B O   1 
ATOM   2264 C CB  . LEU   B 1 22  ? 0.94925   -35.63170 12.04515  1.000 21.05305 ? 377  LEU   B CB  1 
ATOM   2265 C CG  . LEU   B 1 22  ? 0.30801   -36.91763 11.61321  1.000 25.92055 ? 377  LEU   B CG  1 
ATOM   2266 C CD1 . LEU   B 1 22  ? -0.57465  -36.60167 10.41567  1.000 20.96785 ? 377  LEU   B CD1 1 
ATOM   2267 C CD2 . LEU   B 1 22  ? 1.41918   -37.79552 11.22052  1.000 27.58215 ? 377  LEU   B CD2 1 
ATOM   2268 N N   . GLY   B 1 23  ? 2.03902   -33.72045 14.38381  1.000 22.16900 ? 378  GLY   B N   1 
ATOM   2269 C CA  . GLY   B 1 23  ? 2.51127   -32.37533 14.64080  1.000 27.15463 ? 378  GLY   B CA  1 
ATOM   2270 C C   . GLY   B 1 23  ? 1.82043   -31.78628 15.84956  1.000 22.97765 ? 378  GLY   B C   1 
ATOM   2271 O O   . GLY   B 1 23  ? 0.83916   -32.32533 16.38200  1.000 23.89618 ? 378  GLY   B O   1 
ATOM   2272 N N   . SER   B 1 24  ? 2.32839   -30.62844 16.25070  1.000 23.98898 ? 379  SER   B N   1 
ATOM   2273 C CA  . SER   B 1 24  ? 1.94048   -30.03619 17.50877  1.000 24.50186 ? 379  SER   B CA  1 
ATOM   2274 C C   . SER   B 1 24  ? 1.99853   -28.53290 17.32328  1.000 36.40087 ? 379  SER   B C   1 
ATOM   2275 O O   . SER   B 1 24  ? 2.74717   -28.03451 16.48150  1.000 35.86431 ? 379  SER   B O   1 
ATOM   2276 C CB  . SER   B 1 24  ? 2.89986   -30.48547 18.62282  1.000 38.95443 ? 379  SER   B CB  1 
ATOM   2277 O OG  . SER   B 1 24  ? 2.22238   -30.65446 19.84447  1.000 50.11008 ? 379  SER   B OG  1 
ATOM   2278 N N   . GLY   B 1 25  ? 1.18565   -27.82355 18.09315  1.000 29.50486 ? 380  GLY   B N   1 
ATOM   2279 C CA  . GLY   B 1 25  ? 1.17288   -26.37529 18.06582  1.000 40.51939 ? 380  GLY   B CA  1 
ATOM   2280 C C   . GLY   B 1 25  ? 0.51891   -25.88206 19.33648  1.000 37.70712 ? 380  GLY   B C   1 
ATOM   2281 O O   . GLY   B 1 25  ? 0.18476   -26.66220 20.22971  1.000 36.09820 ? 380  GLY   B O   1 
ATOM   2282 N N   . ASN   B 1 26  ? 0.33130   -24.56213 19.41235  1.000 44.25861 ? 381  ASN   B N   1 
ATOM   2283 C CA  . ASN   B 1 26  ? -0.28986  -24.00012 20.60228  1.000 42.37635 ? 381  ASN   B CA  1 
ATOM   2284 C C   . ASN   B 1 26  ? -1.75161  -24.41421 20.75046  1.000 43.19811 ? 381  ASN   B C   1 
ATOM   2285 O O   . ASN   B 1 26  ? -2.27459  -24.37431 21.86850  1.000 46.06768 ? 381  ASN   B O   1 
ATOM   2286 C CB  . ASN   B 1 26  ? -0.15207  -22.47661 20.58626  1.000 47.94909 ? 381  ASN   B CB  1 
ATOM   2287 C CG  . ASN   B 1 26  ? 1.26708   -22.02642 20.87625  1.000 55.49304 ? 381  ASN   B CG  1 
ATOM   2288 O OD1 . ASN   B 1 26  ? 1.94942   -22.60698 21.72589  1.000 62.26188 ? 381  ASN   B OD1 1 
ATOM   2289 N ND2 . ASN   B 1 26  ? 1.72840   -21.00281 20.16021  1.000 54.07075 ? 381  ASN   B ND2 1 
ATOM   2290 N N   . PHE   B 1 27  ? -2.41450  -24.82978 19.66048  1.000 46.02050 ? 382  PHE   B N   1 
ATOM   2291 C CA  . PHE   B 1 27  ? -3.79949  -25.31120 19.75099  1.000 41.11004 ? 382  PHE   B CA  1 
ATOM   2292 C C   . PHE   B 1 27  ? -3.89019  -26.66561 20.43760  1.000 45.09813 ? 382  PHE   B C   1 
ATOM   2293 O O   . PHE   B 1 27  ? -4.88397  -26.96210 21.12051  1.000 35.68911 ? 382  PHE   B O   1 
ATOM   2294 C CB  . PHE   B 1 27  ? -4.42363  -25.42497 18.35515  1.000 38.91681 ? 382  PHE   B CB  1 
ATOM   2295 C CG  . PHE   B 1 27  ? -3.56732  -26.19386 17.36123  1.000 37.63674 ? 382  PHE   B CG  1 
ATOM   2296 C CD1 . PHE   B 1 27  ? -2.55894  -25.56261 16.66168  1.000 37.06863 ? 382  PHE   B CD1 1 
ATOM   2297 C CD2 . PHE   B 1 27  ? -3.77389  -27.55752 17.13091  1.000 33.65197 ? 382  PHE   B CD2 1 
ATOM   2298 C CE1 . PHE   B 1 27  ? -1.74432  -26.26521 15.76681  1.000 33.70792 ? 382  PHE   B CE1 1 
ATOM   2299 C CE2 . PHE   B 1 27  ? -2.98112  -28.26059 16.22762  1.000 29.27145 ? 382  PHE   B CE2 1 
ATOM   2300 C CZ  . PHE   B 1 27  ? -1.96828  -27.62555 15.54372  1.000 37.06586 ? 382  PHE   B CZ  1 
ATOM   2301 N N   . GLY   B 1 28  ? -2.86722  -27.48873 20.26870  1.000 34.28534 ? 383  GLY   B N   1 
ATOM   2302 C CA  . GLY   B 1 28  ? -2.94535  -28.88622 20.59428  1.000 28.80729 ? 383  GLY   B CA  1 
ATOM   2303 C C   . GLY   B 1 28  ? -2.14385  -29.61797 19.55068  1.000 28.70885 ? 383  GLY   B C   1 
ATOM   2304 O O   . GLY   B 1 28  ? -1.04158  -29.19018 19.18827  1.000 27.83946 ? 383  GLY   B O   1 
ATOM   2305 N N   . THR   B 1 29  ? -2.71757  -30.67950 19.00145  1.000 23.13884 ? 384  THR   B N   1 
ATOM   2306 C CA  . THR   B 1 29  ? -1.95328  -31.60617 18.19342  1.000 19.31359 ? 384  THR   B CA  1 
ATOM   2307 C C   . THR   B 1 29  ? -2.74529  -31.95920 16.94521  1.000 17.18922 ? 384  THR   B C   1 
ATOM   2308 O O   . THR   B 1 29  ? -3.95329  -31.70643 16.84717  1.000 20.75313 ? 384  THR   B O   1 
ATOM   2309 C CB  . THR   B 1 29  ? -1.64166  -32.89623 18.95837  1.000 27.45963 ? 384  THR   B CB  1 
ATOM   2310 O OG1 . THR   B 1 29  ? -2.86509  -33.41123 19.46965  1.000 30.39056 ? 384  THR   B OG1 1 
ATOM   2311 C CG2 . THR   B 1 29  ? -0.71881  -32.60820 20.16299  1.000 34.12167 ? 384  THR   B CG2 1 
ATOM   2312 N N   . VAL   B 1 30  ? -2.03129  -32.51926 15.97840  1.000 18.76699 ? 385  VAL   B N   1 
ATOM   2313 C CA  . VAL   B 1 30  ? -2.61239  -33.14907 14.80186  1.000 18.18856 ? 385  VAL   B CA  1 
ATOM   2314 C C   . VAL   B 1 30  ? -2.22765  -34.61824 14.83097  1.000 19.46319 ? 385  VAL   B C   1 
ATOM   2315 O O   . VAL   B 1 30  ? -1.04164  -34.94170 14.91982  1.000 20.42141 ? 385  VAL   B O   1 
ATOM   2316 C CB  . VAL   B 1 30  ? -2.11557  -32.51695 13.48812  1.000 20.23951 ? 385  VAL   B CB  1 
ATOM   2317 C CG1 . VAL   B 1 30  ? -2.71718  -33.29949 12.28628  1.000 19.22753 ? 385  VAL   B CG1 1 
ATOM   2318 C CG2 . VAL   B 1 30  ? -2.49515  -31.04903 13.42333  1.000 26.24823 ? 385  VAL   B CG2 1 
ATOM   2319 N N   . LYS   B 1 31  ? -3.21770  -35.48891 14.66525  1.000 17.94309 ? 386  LYS   B N   1 
ATOM   2320 C CA  . LYS   B 1 31  ? -2.99784  -36.92791 14.64556  1.000 17.36551 ? 386  LYS   B CA  1 
ATOM   2321 C C   . LYS   B 1 31  ? -3.60869  -37.52268 13.38976  1.000 17.20198 ? 386  LYS   B C   1 
ATOM   2322 O O   . LYS   B 1 31  ? -4.60549  -37.01849 12.88028  1.000 19.31194 ? 386  LYS   B O   1 
ATOM   2323 C CB  . LYS   B 1 31  ? -3.63165  -37.62241 15.87691  1.000 21.46231 ? 386  LYS   B CB  1 
ATOM   2324 C CG  . LYS   B 1 31  ? -2.84864  -37.39218 17.15045  1.000 24.51829 ? 386  LYS   B CG  1 
ATOM   2325 C CD  . LYS   B 1 31  ? -3.34408  -38.38385 18.21596  1.000 27.88646 ? 386  LYS   B CD  1 
ATOM   2326 C CE  . LYS   B 1 31  ? -2.37077  -38.48465 19.38232  1.000 43.69629 ? 386  LYS   B CE  1 
ATOM   2327 N NZ  . LYS   B 1 31  ? -2.91042  -39.41909 20.40319  1.000 38.28396 ? 386  LYS   B NZ  1 
ATOM   2328 N N   . LYS   B 1 32  ? -3.02037  -38.61266 12.93381  1.000 16.47566 ? 387  LYS   B N   1 
ATOM   2329 C CA  . LYS   B 1 32  ? -3.64061  -39.42498 11.90624  1.000 16.29417 ? 387  LYS   B CA  1 
ATOM   2330 C C   . LYS   B 1 32  ? -4.68444  -40.32671 12.53271  1.000 18.99265 ? 387  LYS   B C   1 
ATOM   2331 O O   . LYS   B 1 32  ? -4.52585  -40.81151 13.66372  1.000 18.90161 ? 387  LYS   B O   1 
ATOM   2332 C CB  . LYS   B 1 32  ? -2.57277  -40.29338 11.24274  1.000 18.50930 ? 387  LYS   B CB  1 
ATOM   2333 C CG  . LYS   B 1 32  ? -3.04210  -41.17315 10.18513  1.000 18.42421 ? 387  LYS   B CG  1 
ATOM   2334 C CD  . LYS   B 1 32  ? -1.81113  -41.65712 9.38947   1.000 21.44523 ? 387  LYS   B CD  1 
ATOM   2335 C CE  . LYS   B 1 32  ? -2.21245  -42.30822 8.12913   1.000 22.35289 ? 387  LYS   B CE  1 
ATOM   2336 N NZ  . LYS   B 1 32  ? -0.90377  -42.76327 7.45224   1.000 20.20826 ? 387  LYS   B NZ  1 
ATOM   2337 N N   . GLY   B 1 33  ? -5.71867  -40.61211 11.76534  1.000 15.47030 ? 388  GLY   B N   1 
ATOM   2338 C CA  . GLY   B 1 33  ? -6.71743  -41.54384 12.23664  1.000 21.87674 ? 388  GLY   B CA  1 
ATOM   2339 C C   . GLY   B 1 33  ? -7.46972  -42.16938 11.08076  1.000 17.92365 ? 388  GLY   B C   1 
ATOM   2340 O O   . GLY   B 1 33  ? -7.14707  -41.95980 9.89642   1.000 15.92442 ? 388  GLY   B O   1 
ATOM   2341 N N   . TYR   B 1 34  ? -8.49529  -42.93740 11.45312  1.000 17.25121 ? 389  TYR   B N   1 
ATOM   2342 C CA  . TYR   B 1 34  ? -9.37469  -43.60208 10.51390  1.000 17.75448 ? 389  TYR   B CA  1 
ATOM   2343 C C   . TYR   B 1 34  ? -10.79949 -43.36819 10.93453  1.000 21.54092 ? 389  TYR   B C   1 
ATOM   2344 O O   . TYR   B 1 34  ? -11.10990 -43.45452 12.11792  1.000 25.99084 ? 389  TYR   B O   1 
ATOM   2345 C CB  . TYR   B 1 34  ? -9.11001  -45.11092 10.51115  1.000 21.80807 ? 389  TYR   B CB  1 
ATOM   2346 C CG  . TYR   B 1 34  ? -7.77727  -45.37262 9.97666   1.000 21.84668 ? 389  TYR   B CG  1 
ATOM   2347 C CD1 . TYR   B 1 34  ? -7.59826  -45.34787 8.61799   1.000 23.79827 ? 389  TYR   B CD1 1 
ATOM   2348 C CD2 . TYR   B 1 34  ? -6.68837  -45.49993 10.80575  1.000 20.28005 ? 389  TYR   B CD2 1 
ATOM   2349 C CE1 . TYR   B 1 34  ? -6.35365  -45.53005 8.08489   1.000 22.48079 ? 389  TYR   B CE1 1 
ATOM   2350 C CE2 . TYR   B 1 34  ? -5.39840  -45.67390 10.27187  1.000 26.58415 ? 389  TYR   B CE2 1 
ATOM   2351 C CZ  . TYR   B 1 34  ? -5.26978  -45.68506 8.90439   1.000 26.40811 ? 389  TYR   B CZ  1 
ATOM   2352 O OH  . TYR   B 1 34  ? -4.04821  -45.83832 8.29749   1.000 30.90156 ? 389  TYR   B OH  1 
ATOM   2353 N N   . TYR   B 1 35  ? -11.67155 -43.13022 9.97882   1.000 18.74113 ? 390  TYR   B N   1 
ATOM   2354 C CA  . TYR   B 1 35  ? -13.08501 -42.99891 10.25775  1.000 17.94997 ? 390  TYR   B CA  1 
ATOM   2355 C C   . TYR   B 1 35  ? -13.83547 -44.04182 9.45885   1.000 19.89693 ? 390  TYR   B C   1 
ATOM   2356 O O   . TYR   B 1 35  ? -13.74734 -44.08574 8.22033   1.000 19.81119 ? 390  TYR   B O   1 
ATOM   2357 C CB  . TYR   B 1 35  ? -13.60402 -41.58605 9.98143   1.000 19.58185 ? 390  TYR   B CB  1 
ATOM   2358 C CG  . TYR   B 1 35  ? -14.94603 -41.39243 10.64640  1.000 23.37600 ? 390  TYR   B CG  1 
ATOM   2359 C CD1 . TYR   B 1 35  ? -15.02839 -41.25762 12.02748  1.000 23.75693 ? 390  TYR   B CD1 1 
ATOM   2360 C CD2 . TYR   B 1 35  ? -16.09946 -41.37940 9.91941   1.000 23.87302 ? 390  TYR   B CD2 1 
ATOM   2361 C CE1 . TYR   B 1 35  ? -16.25948 -41.09839 12.66156  1.000 22.89058 ? 390  TYR   B CE1 1 
ATOM   2362 C CE2 . TYR   B 1 35  ? -17.36085 -41.20042 10.55771  1.000 25.32059 ? 390  TYR   B CE2 1 
ATOM   2363 C CZ  . TYR   B 1 35  ? -17.39788 -41.07881 11.92512  1.000 26.68765 ? 390  TYR   B CZ  1 
ATOM   2364 O OH  . TYR   B 1 35  ? -18.61460 -40.92968 12.58189  1.000 29.84196 ? 390  TYR   B OH  1 
ATOM   2365 N N   . GLN   B 1 36  ? -14.57940 -44.88386 10.15954  1.000 19.06258 ? 391  GLN   B N   1 
ATOM   2366 C CA  . GLN   B 1 36  ? -15.31012 -45.93945 9.47304   1.000 19.29520 ? 391  GLN   B CA  1 
ATOM   2367 C C   . GLN   B 1 36  ? -16.55967 -45.40088 8.77063   1.000 26.97302 ? 391  GLN   B C   1 
ATOM   2368 O O   . GLN   B 1 36  ? -17.49667 -44.90666 9.41807   1.000 26.76909 ? 391  GLN   B O   1 
ATOM   2369 C CB  . GLN   B 1 36  ? -15.65510 -47.00638 10.49941  1.000 21.70653 ? 391  GLN   B CB  1 
ATOM   2370 C CG  . GLN   B 1 36  ? -16.50432 -48.12908 9.96380   1.000 28.67168 ? 391  GLN   B CG  1 
ATOM   2371 C CD  . GLN   B 1 36  ? -15.74394 -48.90602 8.91080   1.000 30.64430 ? 391  GLN   B CD  1 
ATOM   2372 O OE1 . GLN   B 1 36  ? -14.63670 -49.40242 9.15562   1.000 31.74056 ? 391  GLN   B OE1 1 
ATOM   2373 N NE2 . GLN   B 1 36  ? -16.30602 -48.96246 7.71972   1.000 30.73463 ? 391  GLN   B NE2 1 
ATOM   2374 N N   . MET   B 1 37  ? -16.57969 -45.49474 7.44574   1.000 25.58086 ? 392  MET   B N   1 
ATOM   2375 C CA  . MET   B 1 37  ? -17.75234 -45.14064 6.65442   1.000 27.16616 ? 392  MET   B CA  1 
ATOM   2376 C C   . MET   B 1 37  ? -18.70539 -46.33433 6.51714   1.000 27.26381 ? 392  MET   B C   1 
ATOM   2377 O O   . MET   B 1 37  ? -18.58653 -47.35196 7.20802   1.000 29.10408 ? 392  MET   B O   1 
ATOM   2378 C CB  . MET   B 1 37  ? -17.33551 -44.64300 5.27632   1.000 28.64414 ? 392  MET   B CB  1 
ATOM   2379 C CG  . MET   B 1 37  ? -16.42231 -43.47205 5.27152   1.000 26.26366 ? 392  MET   B CG  1 
ATOM   2380 S SD  . MET   B 1 37  ? -17.25632 -42.16613 6.12151   1.000 47.99793 ? 392  MET   B SD  1 
ATOM   2381 C CE  . MET   B 1 37  ? -15.99016 -40.92625 6.07035   1.000 31.86829 ? 392  MET   B CE  1 
ATOM   2382 N N   . LYS   B 1 38  ? -19.64213 -46.22814 5.57084   1.000 35.05154 ? 393  LYS   B N   1 
ATOM   2383 C CA  . LYS   B 1 38  ? -20.62810 -47.29297 5.38739   1.000 37.49989 ? 393  LYS   B CA  1 
ATOM   2384 C C   . LYS   B 1 38  ? -19.97429 -48.62079 5.01391   1.000 39.70292 ? 393  LYS   B C   1 
ATOM   2385 O O   . LYS   B 1 38  ? -20.43520 -49.67650 5.46222   1.000 38.49737 ? 393  LYS   B O   1 
ATOM   2386 C CB  . LYS   B 1 38  ? -21.65498 -46.87479 4.33780   1.000 43.01436 ? 393  LYS   B CB  1 
ATOM   2387 C CG  . LYS   B 1 38  ? -22.38914 -45.57629 4.65373   1.000 45.72117 ? 393  LYS   B CG  1 
ATOM   2388 C CD  . LYS   B 1 38  ? -23.75342 -45.84430 5.28717   1.000 57.25441 ? 393  LYS   B CD  1 
ATOM   2389 C CE  . LYS   B 1 38  ? -24.67607 -44.64194 5.15820   1.000 46.35636 ? 393  LYS   B CE  1 
ATOM   2390 N NZ  . LYS   B 1 38  ? -24.83122 -44.28876 3.72593   1.000 56.50831 ? 393  LYS   B NZ  1 
ATOM   2391 N N   . LYS   B 1 39  ? -18.88231 -48.59205 4.23226   1.000 35.29489 ? 394  LYS   B N   1 
ATOM   2392 C CA  . LYS   B 1 39  ? -18.10234 -49.79919 3.96642   1.000 32.33424 ? 394  LYS   B CA  1 
ATOM   2393 C C   . LYS   B 1 39  ? -16.59937 -49.49937 4.05588   1.000 20.50594 ? 394  LYS   B C   1 
ATOM   2394 O O   . LYS   B 1 39  ? -15.86164 -50.17212 4.79403   1.000 23.96550 ? 394  LYS   B O   1 
ATOM   2395 C CB  . LYS   B 1 39  ? -18.46560 -50.37597 2.58660   1.000 34.12999 ? 394  LYS   B CB  1 
ATOM   2396 C CG  . LYS   B 1 39  ? -17.60131 -51.58339 2.18924   1.000 33.97350 ? 394  LYS   B CG  1 
ATOM   2397 C CD  . LYS   B 1 39  ? -18.19509 -52.43347 1.05333   1.000 29.02587 ? 394  LYS   B CD  1 
ATOM   2398 C CE  . LYS   B 1 39  ? -18.64943 -51.60928 -0.10237  1.000 26.62168 ? 394  LYS   B CE  1 
ATOM   2399 N NZ  . LYS   B 1 39  ? -19.29401 -52.47720 -1.14879  1.000 21.62081 ? 394  LYS   B NZ  1 
ATOM   2400 N N   . VAL   B 1 40  ? -16.16843 -48.48416 3.32940   1.000 29.95095 ? 395  VAL   B N   1 
ATOM   2401 C CA  . VAL   B 1 40  ? -14.74819 -48.15127 3.32457   1.000 21.58937 ? 395  VAL   B CA  1 
ATOM   2402 C C   . VAL   B 1 40  ? -14.37399 -47.47147 4.62652   1.000 26.83480 ? 395  VAL   B C   1 
ATOM   2403 O O   . VAL   B 1 40  ? -15.23595 -46.99270 5.39196   1.000 23.00395 ? 395  VAL   B O   1 
ATOM   2404 C CB  . VAL   B 1 40  ? -14.43685 -47.26755 2.11489   1.000 20.23410 ? 395  VAL   B CB  1 
ATOM   2405 C CG1 . VAL   B 1 40  ? -14.85545 -48.02747 0.85518   1.000 24.83245 ? 395  VAL   B CG1 1 
ATOM   2406 C CG2 . VAL   B 1 40  ? -15.12538 -45.91397 2.23222   1.000 23.62102 ? 395  VAL   B CG2 1 
ATOM   2407 N N   . VAL   B 1 41  ? -13.07779 -47.47642 4.91357   1.000 17.96625 ? 396  VAL   B N   1 
ATOM   2408 C CA  . VAL   B 1 41  ? -12.54755 -46.58813 5.93963   1.000 16.84166 ? 396  VAL   B CA  1 
ATOM   2409 C C   . VAL   B 1 41  ? -11.88002 -45.43005 5.23538   1.000 17.82198 ? 396  VAL   B C   1 
ATOM   2410 O O   . VAL   B 1 41  ? -11.35758 -45.56481 4.14154   1.000 16.00904 ? 396  VAL   B O   1 
ATOM   2411 C CB  . VAL   B 1 41  ? -11.58620 -47.26390 6.94315   1.000 20.49753 ? 396  VAL   B CB  1 
ATOM   2412 C CG1 . VAL   B 1 41  ? -12.29172 -48.43856 7.53806   1.000 29.79582 ? 396  VAL   B CG1 1 
ATOM   2413 C CG2 . VAL   B 1 41  ? -10.28480 -47.70712 6.28227   1.000 24.67109 ? 396  VAL   B CG2 1 
ATOM   2414 N N   . LYS   B 1 42  ? -11.94290 -44.26482 5.86576   1.000 15.26520 ? 397  LYS   B N   1 
ATOM   2415 C CA  . LYS   B 1 42  ? -11.32215 -43.04808 5.37839   1.000 14.40233 ? 397  LYS   B CA  1 
ATOM   2416 C C   . LYS   B 1 42  ? -10.17621 -42.64269 6.29268   1.000 16.22871 ? 397  LYS   B C   1 
ATOM   2417 O O   . LYS   B 1 42  ? -10.33725 -42.54424 7.52339   1.000 16.64017 ? 397  LYS   B O   1 
ATOM   2418 C CB  . LYS   B 1 42  ? -12.36901 -41.92534 5.29825   1.000 18.10765 ? 397  LYS   B CB  1 
ATOM   2419 C CG  . LYS   B 1 42  ? -11.87375 -40.74584 4.50183   1.000 33.21945 ? 397  LYS   B CG  1 
ATOM   2420 C CD  . LYS   B 1 42  ? -13.03534 -39.95940 3.91565   1.000 34.21725 ? 397  LYS   B CD  1 
ATOM   2421 C CE  . LYS   B 1 42  ? -12.54123 -38.73771 3.16591   1.000 31.24334 ? 397  LYS   B CE  1 
ATOM   2422 N NZ  . LYS   B 1 42  ? -12.07773 -39.03753 1.77578   1.000 29.68186 ? 397  LYS   B NZ  1 
ATOM   2423 N N   . THR   B 1 43  ? -9.00738  -42.41326 5.70147   1.000 13.43850 ? 398  THR   B N   1 
ATOM   2424 C CA  . THR   B 1 43  ? -7.86736  -41.90666 6.44216   1.000 13.29824 ? 398  THR   B CA  1 
ATOM   2425 C C   . THR   B 1 43  ? -8.12147  -40.43067 6.72116   1.000 13.73342 ? 398  THR   B C   1 
ATOM   2426 O O   . THR   B 1 43  ? -8.52689  -39.67484 5.82089   1.000 15.74970 ? 398  THR   B O   1 
ATOM   2427 C CB  . THR   B 1 43  ? -6.59353  -42.03721 5.60959   1.000 14.05050 ? 398  THR   B CB  1 
ATOM   2428 O OG1 . THR   B 1 43  ? -6.46606  -43.42252 5.19770   1.000 16.38571 ? 398  THR   B OG1 1 
ATOM   2429 C CG2 . THR   B 1 43  ? -5.43197  -41.73612 6.45084   1.000 13.44882 ? 398  THR   B CG2 1 
ATOM   2430 N N   . VAL   B 1 44  ? -7.95416  -40.03252 7.98398   1.000 12.79933 ? 399  VAL   B N   1 
ATOM   2431 C CA  . VAL   B 1 44  ? -8.25406  -38.65317 8.37282   1.000 12.42587 ? 399  VAL   B CA  1 
ATOM   2432 C C   . VAL   B 1 44  ? -7.09634  -38.02989 9.12310   1.000 12.45849 ? 399  VAL   B C   1 
ATOM   2433 O O   . VAL   B 1 44  ? -6.23807  -38.70122 9.69186   1.000 13.21061 ? 399  VAL   B O   1 
ATOM   2434 C CB  . VAL   B 1 44  ? -9.53358  -38.57460 9.23756   1.000 12.64910 ? 399  VAL   B CB  1 
ATOM   2435 C CG1 . VAL   B 1 44  ? -10.71599 -38.95121 8.37317   1.000 13.93732 ? 399  VAL   B CG1 1 
ATOM   2436 C CG2 . VAL   B 1 44  ? -9.42625  -39.48832 10.48168  1.000 14.99594 ? 399  VAL   B CG2 1 
ATOM   2437 N N   . ALA   B 1 45  ? -7.07087  -36.69635 9.08628   1.000 12.25947 ? 400  ALA   B N   1 
ATOM   2438 C CA  . ALA   B 1 45  ? -6.18453  -35.93166 9.94431   1.000 12.11866 ? 400  ALA   B CA  1 
ATOM   2439 C C   . ALA   B 1 45  ? -7.08856  -35.26492 10.96308  1.000 12.11237 ? 400  ALA   B C   1 
ATOM   2440 O O   . ALA   B 1 45  ? -8.14883  -34.73803 10.61206  1.000 14.07912 ? 400  ALA   B O   1 
ATOM   2441 C CB  . ALA   B 1 45  ? -5.39080  -34.88512 9.15304   1.000 16.15300 ? 400  ALA   B CB  1 
ATOM   2442 N N   . VAL   B 1 46  ? -6.64188  -35.26252 12.20427  1.000 15.28031 ? 401  VAL   B N   1 
ATOM   2443 C CA  . VAL   B 1 46  ? -7.52726  -34.85784 13.29006  1.000 13.97158 ? 401  VAL   B CA  1 
ATOM   2444 C C   . VAL   B 1 46  ? -6.83216  -33.76669 14.08547  1.000 14.52974 ? 401  VAL   B C   1 
ATOM   2445 O O   . VAL   B 1 46  ? -5.73288  -33.98398 14.61783  1.000 16.68764 ? 401  VAL   B O   1 
ATOM   2446 C CB  . VAL   B 1 46  ? -7.88156  -36.03344 14.21420  1.000 13.71870 ? 401  VAL   B CB  1 
ATOM   2447 C CG1 . VAL   B 1 46  ? -8.91516  -35.60100 15.28878  1.000 17.40186 ? 401  VAL   B CG1 1 
ATOM   2448 C CG2 . VAL   B 1 46  ? -8.45496  -37.21241 13.42380  1.000 16.92326 ? 401  VAL   B CG2 1 
ATOM   2449 N N   . LYS   B 1 47  ? -7.44825  -32.58293 14.14019  1.000 14.05196 ? 402  LYS   B N   1 
ATOM   2450 C CA  . LYS   B 1 47  ? -6.93573  -31.50618 14.98486  1.000 17.91590 ? 402  LYS   B CA  1 
ATOM   2451 C C   . LYS   B 1 47  ? -7.55180  -31.66506 16.38079  1.000 14.55978 ? 402  LYS   B C   1 
ATOM   2452 O O   . LYS   B 1 47  ? -8.77122  -31.68212 16.51316  1.000 15.91269 ? 402  LYS   B O   1 
ATOM   2453 C CB  . LYS   B 1 47  ? -7.27918  -30.15315 14.35765  1.000 15.19268 ? 402  LYS   B CB  1 
ATOM   2454 C CG  . LYS   B 1 47  ? -6.96518  -28.93930 15.26488  1.000 17.93708 ? 402  LYS   B CG  1 
ATOM   2455 C CD  . LYS   B 1 47  ? -7.21387  -27.60501 14.49389  1.000 19.30561 ? 402  LYS   B CD  1 
ATOM   2456 C CE  . LYS   B 1 47  ? -6.99362  -26.41601 15.43227  1.000 26.37603 ? 402  LYS   B CE  1 
ATOM   2457 N NZ  . LYS   B 1 47  ? -7.12688  -25.15173 14.65215  1.000 23.47150 ? 402  LYS   B NZ  1 
ATOM   2458 N N   . ILE   B 1 48  ? -6.70925  -31.84248 17.38903  1.000 17.15431 ? 403  ILE   B N   1 
ATOM   2459 C CA  . ILE   B 1 48  ? -7.14750  -32.16076 18.74277  1.000 15.93162 ? 403  ILE   B CA  1 
ATOM   2460 C C   . ILE   B 1 48  ? -6.77467  -30.98943 19.63382  1.000 19.62857 ? 403  ILE   B C   1 
ATOM   2461 O O   . ILE   B 1 48  ? -5.59061  -30.67317 19.75481  1.000 20.65397 ? 403  ILE   B O   1 
ATOM   2462 C CB  . ILE   B 1 48  ? -6.50833  -33.45499 19.23964  1.000 18.28201 ? 403  ILE   B CB  1 
ATOM   2463 C CG1 . ILE   B 1 48  ? -6.84322  -34.57354 18.24256  1.000 19.95372 ? 403  ILE   B CG1 1 
ATOM   2464 C CG2 . ILE   B 1 48  ? -7.03196  -33.77325 20.63107  1.000 26.49594 ? 403  ILE   B CG2 1 
ATOM   2465 C CD1 . ILE   B 1 48  ? -6.06975  -35.85298 18.44838  1.000 26.51926 ? 403  ILE   B CD1 1 
ATOM   2466 N N   . LEU   B 1 49  ? -7.76398  -30.40360 20.31136  1.000 20.85828 ? 404  LEU   B N   1 
ATOM   2467 C CA  . LEU   B 1 49  ? -7.47491  -29.28247 21.21050  1.000 27.27163 ? 404  LEU   B CA  1 
ATOM   2468 C C   . LEU   B 1 49  ? -6.77479  -29.71141 22.50336  1.000 24.93044 ? 404  LEU   B C   1 
ATOM   2469 O O   . LEU   B 1 49  ? -6.96342  -30.82359 23.00831  1.000 26.45534 ? 404  LEU   B O   1 
ATOM   2470 C CB  . LEU   B 1 49  ? -8.75311  -28.53983 21.57609  1.000 23.52098 ? 404  LEU   B CB  1 
ATOM   2471 C CG  . LEU   B 1 49  ? -9.44561  -27.86625 20.41212  1.000 26.55898 ? 404  LEU   B CG  1 
ATOM   2472 C CD1 . LEU   B 1 49  ? -10.59441 -27.00531 20.97698  1.000 30.21141 ? 404  LEU   B CD1 1 
ATOM   2473 C CD2 . LEU   B 1 49  ? -8.45650  -26.98366 19.67213  1.000 29.12233 ? 404  LEU   B CD2 1 
ATOM   2474 N N   . LYS   B 1 50  ? -5.95588  -28.79481 23.02654  1.000 29.92917 ? 405  LYS   B N   1 
ATOM   2475 C CA  . LYS   B 1 50  ? -5.38760  -28.82015 24.38340  1.000 39.07406 ? 405  LYS   B CA  1 
ATOM   2476 C C   . LYS   B 1 50  ? -4.16944  -29.70313 24.50689  1.000 50.35568 ? 405  LYS   B C   1 
ATOM   2477 O O   . LYS   B 1 50  ? -3.08398  -29.20230 24.79226  1.000 55.30008 ? 405  LYS   B O   1 
ATOM   2478 C CB  . LYS   B 1 50  ? -6.43680  -29.25362 25.41508  1.000 39.88826 ? 405  LYS   B CB  1 
ATOM   2479 C CG  . LYS   B 1 50  ? -7.57825  -28.28559 25.54713  1.000 37.16872 ? 405  LYS   B CG  1 
ATOM   2480 C CD  . LYS   B 1 50  ? -7.25256  -27.20330 26.58627  1.000 45.28191 ? 405  LYS   B CD  1 
ATOM   2481 C CE  . LYS   B 1 50  ? -7.43213  -27.72599 28.00716  1.000 43.24827 ? 405  LYS   B CE  1 
ATOM   2482 N NZ  . LYS   B 1 50  ? -8.87342  -27.89859 28.31552  1.000 42.81131 ? 405  LYS   B NZ  1 
ATOM   2483 N N   . PRO   B 1 56  ? -11.95827 -22.29477 27.14282  1.000 45.29615 ? 411  PRO   B N   1 
ATOM   2484 C CA  . PRO   B 1 56  ? -13.17714 -21.57028 26.75630  1.000 42.83174 ? 411  PRO   B CA  1 
ATOM   2485 C C   . PRO   B 1 56  ? -13.13033 -21.09227 25.29722  1.000 50.11639 ? 411  PRO   B C   1 
ATOM   2486 O O   . PRO   B 1 56  ? -13.97670 -21.43402 24.46050  1.000 48.47387 ? 411  PRO   B O   1 
ATOM   2487 C CB  . PRO   B 1 56  ? -13.20000 -20.37908 27.72659  1.000 42.33699 ? 411  PRO   B CB  1 
ATOM   2488 C CG  . PRO   B 1 56  ? -11.76401 -20.20008 28.13784  1.000 46.86076 ? 411  PRO   B CG  1 
ATOM   2489 C CD  . PRO   B 1 56  ? -11.18366 -21.58408 28.17548  1.000 43.61683 ? 411  PRO   B CD  1 
ATOM   2490 N N   . ALA   B 1 57  ? -12.09240 -20.31448 24.99608  1.000 47.18838 ? 412  ALA   B N   1 
ATOM   2491 C CA  . ALA   B 1 57  ? -11.99007 -19.65002 23.70671  1.000 39.47438 ? 412  ALA   B CA  1 
ATOM   2492 C C   . ALA   B 1 57  ? -11.56505 -20.61262 22.59984  1.000 42.63208 ? 412  ALA   B C   1 
ATOM   2493 O O   . ALA   B 1 57  ? -12.03583 -20.48997 21.46076  1.000 39.87675 ? 412  ALA   B O   1 
ATOM   2494 C CB  . ALA   B 1 57  ? -11.01234 -18.48161 23.81434  1.000 42.14412 ? 412  ALA   B CB  1 
ATOM   2495 N N   . LEU   B 1 58  ? -10.68370 -21.57045 22.91233  1.000 36.63552 ? 413  LEU   B N   1 
ATOM   2496 C CA  . LEU   B 1 58  ? -10.21914 -22.52572 21.90564  1.000 42.04803 ? 413  LEU   B CA  1 
ATOM   2497 C C   . LEU   B 1 58  ? -11.35879 -23.38455 21.37820  1.000 31.92022 ? 413  LEU   B C   1 
ATOM   2498 O O   . LEU   B 1 58  ? -11.43499 -23.66255 20.17488  1.000 28.84943 ? 413  LEU   B O   1 
ATOM   2499 C CB  . LEU   B 1 58  ? -9.12274  -23.41663 22.48665  1.000 39.60230 ? 413  LEU   B CB  1 
ATOM   2500 C CG  . LEU   B 1 58  ? -7.79883  -22.69972 22.71308  1.000 49.63249 ? 413  LEU   B CG  1 
ATOM   2501 C CD1 . LEU   B 1 58  ? -7.38178  -22.80822 24.18580  1.000 47.33404 ? 413  LEU   B CD1 1 
ATOM   2502 C CD2 . LEU   B 1 58  ? -6.74233  -23.26369 21.76600  1.000 45.53448 ? 413  LEU   B CD2 1 
ATOM   2503 N N   . LYS   B 1 59  ? -12.24409 -23.83066 22.26401  1.000 31.46280 ? 414  LYS   B N   1 
ATOM   2504 C CA  . LYS   B 1 59  ? -13.40384 -24.59837 21.82726  1.000 29.18425 ? 414  LYS   B CA  1 
ATOM   2505 C C   . LYS   B 1 59  ? -14.27358 -23.78823 20.88738  1.000 33.35570 ? 414  LYS   B C   1 
ATOM   2506 O O   . LYS   B 1 59  ? -14.70021 -24.28059 19.83939  1.000 24.38331 ? 414  LYS   B O   1 
ATOM   2507 C CB  . LYS   B 1 59  ? -14.22256 -25.04702 23.03483  1.000 33.00616 ? 414  LYS   B CB  1 
ATOM   2508 C CG  . LYS   B 1 59  ? -15.56843 -25.60629 22.64423  1.000 32.37523 ? 414  LYS   B CG  1 
ATOM   2509 C CD  . LYS   B 1 59  ? -16.68984 -25.22456 23.63029  1.000 49.32176 ? 414  LYS   B CD  1 
ATOM   2510 C CE  . LYS   B 1 59  ? -17.98980 -25.96146 23.27290  1.000 52.34936 ? 414  LYS   B CE  1 
ATOM   2511 N NZ  . LYS   B 1 59  ? -19.13200 -25.72131 24.20783  1.000 63.94314 ? 414  LYS   B NZ  1 
ATOM   2512 N N   . ASP   B 1 60  ? -14.56778 -22.54126 21.25519  1.000 28.48092 ? 415  ASP   B N   1 
ATOM   2513 C CA  . ASP   B 1 60  ? -15.39206 -21.71298 20.38046  1.000 26.98841 ? 415  ASP   B CA  1 
ATOM   2514 C C   . ASP   B 1 60  ? -14.71988 -21.53770 19.02454  1.000 21.68821 ? 415  ASP   B C   1 
ATOM   2515 O O   . ASP   B 1 60  ? -15.38929 -21.55846 17.98083  1.000 24.90682 ? 415  ASP   B O   1 
ATOM   2516 C CB  . ASP   B 1 60  ? -15.62915 -20.34679 21.01210  1.000 30.50338 ? 415  ASP   B CB  1 
ATOM   2517 C CG  . ASP   B 1 60  ? -16.52529 -20.40108 22.22409  1.000 49.95892 ? 415  ASP   B CG  1 
ATOM   2518 O OD1 . ASP   B 1 60  ? -17.43853 -21.25378 22.26148  1.000 43.86059 ? 415  ASP   B OD1 1 
ATOM   2519 O OD2 . ASP   B 1 60  ? -16.31341 -19.55565 23.12486  1.000 43.12909 ? 415  ASP   B OD2 1 
ATOM   2520 N N   . GLU   B 1 61  ? -13.39909 -21.38141 19.03417  1.000 23.68946 ? 416  GLU   B N   1 
ATOM   2521 C CA  . GLU   B 1 61  ? -12.66549 -21.17146 17.79514  1.000 22.24572 ? 416  GLU   B CA  1 
ATOM   2522 C C   . GLU   B 1 61  ? -12.70184 -22.41924 16.93890  1.000 23.30212 ? 416  GLU   B C   1 
ATOM   2523 O O   . GLU   B 1 61  ? -12.83942 -22.31778 15.72624  1.000 19.21213 ? 416  GLU   B O   1 
ATOM   2524 C CB  . GLU   B 1 61  ? -11.23044 -20.75604 18.07856  1.000 28.30874 ? 416  GLU   B CB  1 
ATOM   2525 C CG  . GLU   B 1 61  ? -11.15835 -19.31233 18.54775  1.000 33.71680 ? 416  GLU   B CG  1 
ATOM   2526 C CD  . GLU   B 1 61  ? -10.05816 -19.08491 19.54919  1.000 49.18717 ? 416  GLU   B CD  1 
ATOM   2527 O OE1 . GLU   B 1 61  ? -8.90858  -19.52258 19.30111  1.000 49.14589 ? 416  GLU   B OE1 1 
ATOM   2528 O OE2 . GLU   B 1 61  ? -10.35549 -18.48027 20.60251  1.000 57.69756 ? 416  GLU   B OE2 1 
ATOM   2529 N N   . LEU   B 1 62  ? -12.61848 -23.60677 17.55837  1.000 21.41927 ? 417  LEU   B N   1 
ATOM   2530 C CA  . LEU   B 1 62  ? -12.69936 -24.83140 16.76214  1.000 18.68536 ? 417  LEU   B CA  1 
ATOM   2531 C C   . LEU   B 1 62  ? -14.07139 -24.99113 16.13424  1.000 19.48414 ? 417  LEU   B C   1 
ATOM   2532 O O   . LEU   B 1 62  ? -14.17851 -25.40489 14.96970  1.000 19.77523 ? 417  LEU   B O   1 
ATOM   2533 C CB  . LEU   B 1 62  ? -12.37679 -26.06367 17.62997  1.000 17.26906 ? 417  LEU   B CB  1 
ATOM   2534 C CG  . LEU   B 1 62  ? -12.04704 -27.36002 16.86003  1.000 20.44116 ? 417  LEU   B CG  1 
ATOM   2535 C CD1 . LEU   B 1 62  ? -10.68618 -27.14501 16.25954  1.000 22.96319 ? 417  LEU   B CD1 1 
ATOM   2536 C CD2 . LEU   B 1 62  ? -11.96056 -28.61414 17.76595  1.000 20.65814 ? 417  LEU   B CD2 1 
ATOM   2537 N N   . LEU   B 1 63  ? -15.15076 -24.73261 16.90770  1.000 18.30661 ? 418  LEU   B N   1 
ATOM   2538 C CA  . LEU   B 1 63  ? -16.48919 -24.84617 16.36176  1.000 18.75145 ? 418  LEU   B CA  1 
ATOM   2539 C C   . LEU   B 1 63  ? -16.68628 -23.86618 15.21843  1.000 18.94147 ? 418  LEU   B C   1 
ATOM   2540 O O   . LEU   B 1 63  ? -17.34713 -24.18752 14.22764  1.000 20.49406 ? 418  LEU   B O   1 
ATOM   2541 C CB  . LEU   B 1 63  ? -17.53470 -24.60250 17.45765  1.000 22.30060 ? 418  LEU   B CB  1 
ATOM   2542 C CG  . LEU   B 1 63  ? -17.48229 -25.70412 18.53246  1.000 27.49427 ? 418  LEU   B CG  1 
ATOM   2543 C CD1 . LEU   B 1 63  ? -18.53128 -25.45203 19.57903  1.000 26.59372 ? 418  LEU   B CD1 1 
ATOM   2544 C CD2 . LEU   B 1 63  ? -17.70117 -27.06993 17.93851  1.000 30.47895 ? 418  LEU   B CD2 1 
ATOM   2545 N N   . ALA   B 1 64  ? -16.09878 -22.67023 15.32759  1.000 20.30412 ? 419  ALA   B N   1 
ATOM   2546 C CA  . ALA   B 1 64  ? -16.25462 -21.69184 14.24832  1.000 21.31382 ? 419  ALA   B CA  1 
ATOM   2547 C C   . ALA   B 1 64  ? -15.48210 -22.13800 13.00184  1.000 18.45736 ? 419  ALA   B C   1 
ATOM   2548 O O   . ALA   B 1 64  ? -15.99607 -22.03463 11.88113  1.000 17.95085 ? 419  ALA   B O   1 
ATOM   2549 C CB  . ALA   B 1 64  ? -15.79187 -20.31309 14.72996  1.000 18.47923 ? 419  ALA   B CB  1 
ATOM   2550 N N   . GLU   B 1 65  ? -14.28062 -22.68939 13.21080  1.000 15.44018 ? 420  GLU   B N   1 
ATOM   2551 C CA  . GLU   B 1 65  ? -13.46894 -23.24472 12.12570  1.000 18.22384 ? 420  GLU   B CA  1 
ATOM   2552 C C   . GLU   B 1 65  ? -14.21901 -24.34853 11.41041  1.000 21.07479 ? 420  GLU   B C   1 
ATOM   2553 O O   . GLU   B 1 65  ? -14.26752 -24.38692 10.17893  1.000 17.58123 ? 420  GLU   B O   1 
ATOM   2554 C CB  . GLU   B 1 65  ? -12.17742 -23.77287 12.73667  1.000 15.25048 ? 420  GLU   B CB  1 
ATOM   2555 C CG  . GLU   B 1 65  ? -11.16846 -24.39318 11.75581  1.000 16.77818 ? 420  GLU   B CG  1 
ATOM   2556 C CD  . GLU   B 1 65  ? -9.85648  -24.76885 12.45429  1.000 17.84516 ? 420  GLU   B CD  1 
ATOM   2557 O OE1 . GLU   B 1 65  ? -9.71973  -24.57775 13.68106  1.000 24.34053 ? 420  GLU   B OE1 1 
ATOM   2558 O OE2 . GLU   B 1 65  ? -8.90580  -25.23350 11.79036  1.000 18.84425 ? 420  GLU   B OE2 1 
ATOM   2559 N N   . ALA   B 1 66  ? -14.84704 -25.24853 12.16526  1.000 16.99399 ? 421  ALA   B N   1 
ATOM   2560 C CA  . ALA   B 1 66  ? -15.60264 -26.31049 11.52524  1.000 16.81427 ? 421  ALA   B CA  1 
ATOM   2561 C C   . ALA   B 1 66  ? -16.81143 -25.76270 10.79513  1.000 17.85890 ? 421  ALA   B C   1 
ATOM   2562 O O   . ALA   B 1 66  ? -17.15140 -26.23623 9.71043   1.000 20.85852 ? 421  ALA   B O   1 
ATOM   2563 C CB  . ALA   B 1 66  ? -16.04266 -27.34221 12.58416  1.000 21.61197 ? 421  ALA   B CB  1 
ATOM   2564 N N   . ASN   B 1 67  ? -17.46386 -24.74982 11.36576  1.000 18.42007 ? 422  ASN   B N   1 
ATOM   2565 C CA  . ASN   B 1 67  ? -18.61463 -24.17180 10.70075  1.000 22.31873 ? 422  ASN   B CA  1 
ATOM   2566 C C   . ASN   B 1 67  ? -18.23799 -23.55777 9.34723   1.000 18.31369 ? 422  ASN   B C   1 
ATOM   2567 O O   . ASN   B 1 67  ? -18.99603 -23.68321 8.37959   1.000 25.48891 ? 422  ASN   B O   1 
ATOM   2568 C CB  . ASN   B 1 67  ? -19.24312 -23.13744 11.59839  1.000 20.95846 ? 422  ASN   B CB  1 
ATOM   2569 C CG  . ASN   B 1 67  ? -20.43986 -22.51984 10.96329  1.000 30.74838 ? 422  ASN   B CG  1 
ATOM   2570 O OD1 . ASN   B 1 67  ? -20.33284 -21.49196 10.28708  1.000 43.10300 ? 422  ASN   B OD1 1 
ATOM   2571 N ND2 . ASN   B 1 67  ? -21.59201 -23.15488 11.13738  1.000 36.76007 ? 422  ASN   B ND2 1 
ATOM   2572 N N   . VAL   B 1 68  ? -17.07961 -22.88483 9.25158   1.000 18.97625 ? 423  VAL   B N   1 
ATOM   2573 C CA  . VAL   B 1 68  ? -16.62086 -22.41889 7.94037   1.000 17.61976 ? 423  VAL   B CA  1 
ATOM   2574 C C   . VAL   B 1 68  ? -16.39486 -23.59346 7.00021   1.000 19.12978 ? 423  VAL   B C   1 
ATOM   2575 O O   . VAL   B 1 68  ? -16.84129 -23.59846 5.84459   1.000 19.18742 ? 423  VAL   B O   1 
ATOM   2576 C CB  . VAL   B 1 68  ? -15.33191 -21.59206 8.06345   1.000 16.65447 ? 423  VAL   B CB  1 
ATOM   2577 C CG1 . VAL   B 1 68  ? -14.75533 -21.32062 6.66977   1.000 17.34743 ? 423  VAL   B CG1 1 
ATOM   2578 C CG2 . VAL   B 1 68  ? -15.59018 -20.27529 8.79422   1.000 20.01636 ? 423  VAL   B CG2 1 
ATOM   2579 N N   . MET   B 1 69  ? -15.65007 -24.59490 7.45410   1.000 16.64207 ? 424  MET   B N   1 
ATOM   2580 C CA  . MET   B 1 69  ? -15.27792 -25.66209 6.51867   1.000 14.87145 ? 424  MET   B CA  1 
ATOM   2581 C C   . MET   B 1 69  ? -16.48898 -26.43005 6.00951   1.000 17.38497 ? 424  MET   B C   1 
ATOM   2582 O O   . MET   B 1 69  ? -16.48696 -26.91456 4.87800   1.000 18.50470 ? 424  MET   B O   1 
ATOM   2583 C CB  . MET   B 1 69  ? -14.32055 -26.64298 7.16931   1.000 16.66382 ? 424  MET   B CB  1 
ATOM   2584 C CG  . MET   B 1 69  ? -12.98712 -26.04126 7.55530   1.000 16.77777 ? 424  MET   B CG  1 
ATOM   2585 S SD  . MET   B 1 69  ? -11.82839 -27.23262 8.25455   1.000 18.26109 ? 424  MET   B SD  1 
ATOM   2586 C CE  . MET   B 1 69  ? -11.28602 -28.09611 6.84646   1.000 16.52133 ? 424  MET   B CE  1 
ATOM   2587 N N   . GLN   B 1 70  ? -17.50728 -26.58254 6.85982   1.000 19.33116 ? 425  GLN   B N   1 
ATOM   2588 C CA  . GLN   B 1 70  ? -18.71958 -27.30654 6.49039   1.000 23.46579 ? 425  GLN   B CA  1 
ATOM   2589 C C   . GLN   B 1 70  ? -19.43739 -26.65018 5.32262   1.000 21.66991 ? 425  GLN   B C   1 
ATOM   2590 O O   . GLN   B 1 70  ? -20.13844 -27.32787 4.55918   1.000 25.16918 ? 425  GLN   B O   1 
ATOM   2591 C CB  . GLN   B 1 70  ? -19.61537 -27.39468 7.72240   1.000 25.97123 ? 425  GLN   B CB  1 
ATOM   2592 C CG  . GLN   B 1 70  ? -21.10705 -27.59031 7.47662   1.000 42.82996 ? 425  GLN   B CG  1 
ATOM   2593 C CD  . GLN   B 1 70  ? -21.94433 -27.24331 8.72269   1.000 54.73055 ? 425  GLN   B CD  1 
ATOM   2594 O OE1 . GLN   B 1 70  ? -21.40546 -26.93555 9.79973   1.000 48.34363 ? 425  GLN   B OE1 1 
ATOM   2595 N NE2 . GLN   B 1 70  ? -23.26330 -27.28468 8.57173   1.000 71.18842 ? 425  GLN   B NE2 1 
ATOM   2596 N N   . GLN   B 1 71  ? -19.24134 -25.35790 5.12822   1.000 18.96403 ? 426  GLN   B N   1 
ATOM   2597 C CA  . GLN   B 1 71  ? -19.89344 -24.60046 4.05614   1.000 20.00850 ? 426  GLN   B CA  1 
ATOM   2598 C C   . GLN   B 1 71  ? -19.10004 -24.57963 2.76829   1.000 21.84182 ? 426  GLN   B C   1 
ATOM   2599 O O   . GLN   B 1 71  ? -19.60445 -24.08438 1.76067   1.000 21.34997 ? 426  GLN   B O   1 
ATOM   2600 C CB  . GLN   B 1 71  ? -20.12001 -23.16457 4.49947   1.000 23.04311 ? 426  GLN   B CB  1 
ATOM   2601 C CG  . GLN   B 1 71  ? -20.87359 -23.09200 5.81878   1.000 26.55926 ? 426  GLN   B CG  1 
ATOM   2602 C CD  . GLN   B 1 71  ? -21.06764 -21.69342 6.23792   1.000 26.33115 ? 426  GLN   B CD  1 
ATOM   2603 O OE1 . GLN   B 1 71  ? -20.52230 -21.24200 7.25484   1.000 31.72591 ? 426  GLN   B OE1 1 
ATOM   2604 N NE2 . GLN   B 1 71  ? -21.83983 -20.95865 5.44941   1.000 30.34402 ? 426  GLN   B NE2 1 
ATOM   2605 N N   . LEU   B 1 72  ? -17.88325 -25.11554 2.75695   1.000 21.77344 ? 427  LEU   B N   1 
ATOM   2606 C CA  . LEU   B 1 72  ? -17.03110 -25.06223 1.57851   1.000 20.04510 ? 427  LEU   B CA  1 
ATOM   2607 C C   . LEU   B 1 72  ? -17.01464 -26.39879 0.85383   1.000 23.00792 ? 427  LEU   B C   1 
ATOM   2608 O O   . LEU   B 1 72  ? -16.96776 -27.46187 1.46945   1.000 23.97750 ? 427  LEU   B O   1 
ATOM   2609 C CB  . LEU   B 1 72  ? -15.60909 -24.66573 1.98145   1.000 20.65640 ? 427  LEU   B CB  1 
ATOM   2610 C CG  . LEU   B 1 72  ? -15.58049 -23.37307 2.75341   1.000 18.64394 ? 427  LEU   B CG  1 
ATOM   2611 C CD1 . LEU   B 1 72  ? -14.10334 -23.05687 3.15439   1.000 17.97865 ? 427  LEU   B CD1 1 
ATOM   2612 C CD2 . LEU   B 1 72  ? -16.21626 -22.21598 1.97791   1.000 18.68184 ? 427  LEU   B CD2 1 
ATOM   2613 N N   . ASP   B 1 73  ? -17.03877 -26.33443 -0.46232  1.000 21.26353 ? 428  ASP   B N   1 
ATOM   2614 C CA  . ASP   B 1 73  ? -17.14800 -27.53214 -1.28367  1.000 18.92208 ? 428  ASP   B CA  1 
ATOM   2615 C C   . ASP   B 1 73  ? -16.36263 -27.24992 -2.55886  1.000 21.00153 ? 428  ASP   B C   1 
ATOM   2616 O O   . ASP   B 1 73  ? -16.88491 -26.64932 -3.50023  1.000 24.98727 ? 428  ASP   B O   1 
ATOM   2617 C CB  . ASP   B 1 73  ? -18.62069 -27.82643 -1.54666  1.000 24.34320 ? 428  ASP   B CB  1 
ATOM   2618 C CG  . ASP   B 1 73  ? -18.83591 -28.94718 -2.54778  1.000 41.44667 ? 428  ASP   B CG  1 
ATOM   2619 O OD1 . ASP   B 1 73  ? -17.90221 -29.75876 -2.75443  1.000 28.93798 ? 428  ASP   B OD1 1 
ATOM   2620 O OD2 . ASP   B 1 73  ? -19.95553 -29.01249 -3.12973  1.000 39.47353 ? 428  ASP   B OD2 1 
ATOM   2621 N N   . ASN   B 1 74  ? -15.06695 -27.62147 -2.54428  1.000 18.25866 ? 429  ASN   B N   1 
ATOM   2622 C CA  . ASN   B 1 74  ? -14.18989 -27.29227 -3.67287  1.000 19.51291 ? 429  ASN   B CA  1 
ATOM   2623 C C   . ASN   B 1 74  ? -13.00974 -28.24993 -3.67522  1.000 15.74259 ? 429  ASN   B C   1 
ATOM   2624 O O   . ASN   B 1 74  ? -12.50668 -28.60088 -2.59696  1.000 17.21508 ? 429  ASN   B O   1 
ATOM   2625 C CB  . ASN   B 1 74  ? -13.69457 -25.83336 -3.60556  1.000 19.89968 ? 429  ASN   B CB  1 
ATOM   2626 C CG  . ASN   B 1 74  ? -12.80266 -25.46809 -4.77881  1.000 18.29088 ? 429  ASN   B CG  1 
ATOM   2627 O OD1 . ASN   B 1 74  ? -11.58820 -25.60372 -4.70460  1.000 17.41588 ? 429  ASN   B OD1 1 
ATOM   2628 N ND2 . ASN   B 1 74  ? -13.41444 -25.03166 -5.89046  1.000 21.47130 ? 429  ASN   B ND2 1 
ATOM   2629 N N   . PRO   B 1 75  ? -12.52614 -28.69541 -4.83807  1.000 14.76728 ? 430  PRO   B N   1 
ATOM   2630 C CA  . PRO   B 1 75  ? -11.43930 -29.68730 -4.84360  1.000 15.19899 ? 430  PRO   B CA  1 
ATOM   2631 C C   . PRO   B 1 75  ? -10.13359 -29.17389 -4.26726  1.000 17.58473 ? 430  PRO   B C   1 
ATOM   2632 O O   . PRO   B 1 75  ? -9.30127  -29.99357 -3.87765  1.000 15.86068 ? 430  PRO   B O   1 
ATOM   2633 C CB  . PRO   B 1 75  ? -11.25741 -30.03197 -6.33087  1.000 22.57204 ? 430  PRO   B CB  1 
ATOM   2634 C CG  . PRO   B 1 75  ? -12.50873 -29.53905 -6.99559  1.000 22.22411 ? 430  PRO   B CG  1 
ATOM   2635 C CD  . PRO   B 1 75  ? -12.99844 -28.36189 -6.19303  1.000 18.04880 ? 430  PRO   B CD  1 
ATOM   2636 N N   . TYR   B 1 76  ? -9.96696  -27.86288 -4.15359  1.000 15.10287 ? 431  TYR   B N   1 
ATOM   2637 C CA  . TYR   B 1 76  ? -8.67738  -27.31936 -3.70251  1.000 13.48320 ? 431  TYR   B CA  1 
ATOM   2638 C C   . TYR   B 1 76  ? -8.76262  -26.80038 -2.27996  1.000 15.05402 ? 431  TYR   B C   1 
ATOM   2639 O O   . TYR   B 1 76  ? -7.96746  -25.97221 -1.87831  1.000 12.86713 ? 431  TYR   B O   1 
ATOM   2640 C CB  . TYR   B 1 76  ? -8.20166  -26.24008 -4.68771  1.000 13.42456 ? 431  TYR   B CB  1 
ATOM   2641 C CG  . TYR   B 1 76  ? -8.12133  -26.84974 -6.06752  1.000 14.59881 ? 431  TYR   B CG  1 
ATOM   2642 C CD1 . TYR   B 1 76  ? -7.16096  -27.81051 -6.34831  1.000 12.55082 ? 431  TYR   B CD1 1 
ATOM   2643 C CD2 . TYR   B 1 76  ? -9.06423  -26.51917 -7.01478  1.000 15.74392 ? 431  TYR   B CD2 1 
ATOM   2644 C CE1 . TYR   B 1 76  ? -7.09532  -28.43775 -7.63842  1.000 16.01300 ? 431  TYR   B CE1 1 
ATOM   2645 C CE2 . TYR   B 1 76  ? -9.02011  -27.13353 -8.28717  1.000 16.94416 ? 431  TYR   B CE2 1 
ATOM   2646 C CZ  . TYR   B 1 76  ? -8.04736  -28.07810 -8.55245  1.000 16.60446 ? 431  TYR   B CZ  1 
ATOM   2647 O OH  . TYR   B 1 76  ? -7.95464  -28.71529 -9.79812  1.000 22.22973 ? 431  TYR   B OH  1 
ATOM   2648 N N   . ILE   B 1 77  ? -9.76268  -27.26917 -1.52182  1.000 13.34680 ? 432  ILE   B N   1 
ATOM   2649 C CA  . ILE   B 1 77  ? -9.93390  -26.92388 -0.12018  1.000 13.24332 ? 432  ILE   B CA  1 
ATOM   2650 C C   . ILE   B 1 77  ? -10.05986 -28.19691 0.68658   1.000 15.39658 ? 432  ILE   B C   1 
ATOM   2651 O O   . ILE   B 1 77  ? -10.79991 -29.11039 0.30106   1.000 16.21615 ? 432  ILE   B O   1 
ATOM   2652 C CB  . ILE   B 1 77  ? -11.15238 -26.03162 0.07278   1.000 14.06787 ? 432  ILE   B CB  1 
ATOM   2653 C CG1 . ILE   B 1 77  ? -10.91313 -24.72317 -0.68754  1.000 16.79714 ? 432  ILE   B CG1 1 
ATOM   2654 C CG2 . ILE   B 1 77  ? -11.38928 -25.75537 1.53292   1.000 17.45717 ? 432  ILE   B CG2 1 
ATOM   2655 C CD1 . ILE   B 1 77  ? -12.05788 -23.73493 -0.55101  1.000 22.26298 ? 432  ILE   B CD1 1 
ATOM   2656 N N   . VAL   B 1 78  ? -9.40696  -28.22984 1.85947   1.000 15.13185 ? 433  VAL   B N   1 
ATOM   2657 C CA  . VAL   B 1 78  ? -9.52603  -29.44208 2.68939   1.000 15.15602 ? 433  VAL   B CA  1 
ATOM   2658 C C   . VAL   B 1 78  ? -10.97866 -29.66232 3.12018   1.000 15.27338 ? 433  VAL   B C   1 
ATOM   2659 O O   . VAL   B 1 78  ? -11.63370 -28.72732 3.58412   1.000 16.80843 ? 433  VAL   B O   1 
ATOM   2660 C CB  . VAL   B 1 78  ? -8.62919  -29.31305 3.92439   1.000 13.48914 ? 433  VAL   B CB  1 
ATOM   2661 C CG1 . VAL   B 1 78  ? -8.92772  -30.41968 4.95861   1.000 15.05845 ? 433  VAL   B CG1 1 
ATOM   2662 C CG2 . VAL   B 1 78  ? -7.12497  -29.36246 3.49215   1.000 16.85722 ? 433  VAL   B CG2 1 
ATOM   2663 N N   . ARG   B 1 79  ? -11.44829 -30.90987 3.01844   1.000 17.27872 ? 434  ARG   B N   1 
ATOM   2664 C CA  . ARG   B 1 79  ? -12.82159 -31.29380 3.38089   1.000 15.78600 ? 434  ARG   B CA  1 
ATOM   2665 C C   . ARG   B 1 79  ? -12.85847 -31.69937 4.84702   1.000 15.39778 ? 434  ARG   B C   1 
ATOM   2666 O O   . ARG   B 1 79  ? -12.05848 -32.50479 5.28124   1.000 17.53613 ? 434  ARG   B O   1 
ATOM   2667 C CB  . ARG   B 1 79  ? -13.30469 -32.43599 2.49689   1.000 18.73454 ? 434  ARG   B CB  1 
ATOM   2668 C CG  . ARG   B 1 79  ? -13.32416 -31.96275 1.00726   1.000 28.34453 ? 434  ARG   B CG  1 
ATOM   2669 C CD  . ARG   B 1 79  ? -14.17728 -32.79230 0.06602   1.000 34.16754 ? 434  ARG   B CD  1 
ATOM   2670 N NE  . ARG   B 1 79  ? -14.04368 -32.31820 -1.31268  1.000 32.08590 ? 434  ARG   B NE  1 
ATOM   2671 C CZ  . ARG   B 1 79  ? -14.88416 -31.48396 -1.91619  1.000 34.30909 ? 434  ARG   B CZ  1 
ATOM   2672 N NH1 . ARG   B 1 79  ? -15.90874 -30.94263 -1.26822  1.000 27.51063 ? 434  ARG   B NH1 1 
ATOM   2673 N NH2 . ARG   B 1 79  ? -14.70514 -31.20014 -3.21081  1.000 31.59551 ? 434  ARG   B NH2 1 
ATOM   2674 N N   . MET   B 1 80  ? -13.80581 -31.14237 5.58501   1.000 14.99946 ? 435  MET   B N   1 
ATOM   2675 C CA  . MET   B 1 80  ? -14.07803 -31.60775 6.93449   1.000 14.57160 ? 435  MET   B CA  1 
ATOM   2676 C C   . MET   B 1 80  ? -15.00969 -32.82162 6.88979   1.000 16.12478 ? 435  MET   B C   1 
ATOM   2677 O O   . MET   B 1 80  ? -15.95316 -32.86959 6.09210   1.000 19.30367 ? 435  MET   B O   1 
ATOM   2678 C CB  . MET   B 1 80  ? -14.72797 -30.48206 7.74007   1.000 20.61904 ? 435  MET   B CB  1 
ATOM   2679 C CG  . MET   B 1 80  ? -14.90139 -30.85559 9.19878   1.000 29.47117 ? 435  MET   B CG  1 
ATOM   2680 S SD  . MET   B 1 80  ? -16.00049 -29.67088 9.99907   1.000 31.44190 ? 435  MET   B SD  1 
ATOM   2681 C CE  . MET   B 1 80  ? -17.40254 -30.20549 8.99246   1.000 30.73071 ? 435  MET   B CE  1 
ATOM   2682 N N   . ILE   B 1 81  ? -14.72289 -33.80226 7.73230   1.000 14.34969 ? 436  ILE   B N   1 
ATOM   2683 C CA  . ILE   B 1 81  ? -15.68532 -34.88983 7.96877   1.000 14.35359 ? 436  ILE   B CA  1 
ATOM   2684 C C   . ILE   B 1 81  ? -16.65857 -34.52561 9.07748   1.000 19.05676 ? 436  ILE   B C   1 
ATOM   2685 O O   . ILE   B 1 81  ? -17.87428 -34.69759 8.92781   1.000 20.61400 ? 436  ILE   B O   1 
ATOM   2686 C CB  . ILE   B 1 81  ? -14.91551 -36.15435 8.33171   1.000 16.77875 ? 436  ILE   B CB  1 
ATOM   2687 C CG1 . ILE   B 1 81  ? -13.76999 -36.48396 7.34678   1.000 20.41444 ? 436  ILE   B CG1 1 
ATOM   2688 C CG2 . ILE   B 1 81  ? -15.88643 -37.37095 8.44460   1.000 20.41470 ? 436  ILE   B CG2 1 
ATOM   2689 C CD1 . ILE   B 1 81  ? -14.19291 -36.60031 5.91827   1.000 22.64423 ? 436  ILE   B CD1 1 
ATOM   2690 N N   . GLY   B 1 82  ? -16.13690 -34.01456 10.18632  1.000 16.96361 ? 437  GLY   B N   1 
ATOM   2691 C CA  . GLY   B 1 82  ? -17.02450 -33.52885 11.22495  1.000 17.37724 ? 437  GLY   B CA  1 
ATOM   2692 C C   . GLY   B 1 82  ? -16.23603 -33.18822 12.46821  1.000 15.75019 ? 437  GLY   B C   1 
ATOM   2693 O O   . GLY   B 1 82  ? -15.01953 -33.15264 12.45885  1.000 16.40113 ? 437  GLY   B O   1 
ATOM   2694 N N   . ILE   B 1 83  ? -16.96834 -32.89566 13.53928  1.000 18.07646 ? 438  ILE   B N   1 
ATOM   2695 C CA  . ILE   B 1 83  ? -16.39079 -32.66953 14.84606  1.000 15.83228 ? 438  ILE   B CA  1 
ATOM   2696 C C   . ILE   B 1 83  ? -16.73166 -33.84636 15.74842  1.000 17.35176 ? 438  ILE   B C   1 
ATOM   2697 O O   . ILE   B 1 83  ? -17.76835 -34.48882 15.58907  1.000 21.92637 ? 438  ILE   B O   1 
ATOM   2698 C CB  . ILE   B 1 83  ? -16.92044 -31.35856 15.46115  1.000 20.77983 ? 438  ILE   B CB  1 
ATOM   2699 C CG1 . ILE   B 1 83  ? -16.24814 -30.18697 14.79562  1.000 24.71047 ? 438  ILE   B CG1 1 
ATOM   2700 C CG2 . ILE   B 1 83  ? -16.75097 -31.30208 17.00391  1.000 34.14666 ? 438  ILE   B CG2 1 
ATOM   2701 C CD1 . ILE   B 1 83  ? -14.91800 -29.85416 15.42480  1.000 36.62107 ? 438  ILE   B CD1 1 
ATOM   2702 N N   . CYS   B 1 84  ? -15.87027 -34.10462 16.71188  1.000 19.85394 ? 439  CYS   B N   1 
ATOM   2703 C CA  . CYS   B 1 84  ? -16.11815 -35.16386 17.67761  1.000 20.87635 ? 439  CYS   B CA  1 
ATOM   2704 C C   . CYS   B 1 84  ? -15.76383 -34.59200 19.04442  1.000 20.45011 ? 439  CYS   B C   1 
ATOM   2705 O O   . CYS   B 1 84  ? -14.66438 -34.07417 19.24345  1.000 20.85633 ? 439  CYS   B O   1 
ATOM   2706 C CB  . CYS   B 1 84  ? -15.28392 -36.41417 17.33427  1.000 22.51325 ? 439  CYS   B CB  1 
ATOM   2707 S SG  . CYS   B 1 84  ? -15.64936 -37.86471 18.32834  1.000 29.81915 ? 439  CYS   B SG  1 
ATOM   2708 N N   . GLU   B 1 85  ? -16.67151 -34.72399 19.99537  1.000 21.99158 ? 440  GLU   B N   1 
ATOM   2709 C CA  . GLU   B 1 85  ? -16.46387 -34.24925 21.35455  1.000 24.99200 ? 440  GLU   B CA  1 
ATOM   2710 C C   . GLU   B 1 85  ? -16.20880 -35.46921 22.22799  1.000 22.98857 ? 440  GLU   B C   1 
ATOM   2711 O O   . GLU   B 1 85  ? -17.14225 -36.19085 22.60087  1.000 33.20091 ? 440  GLU   B O   1 
ATOM   2712 C CB  . GLU   B 1 85  ? -17.67923 -33.45398 21.82196  1.000 35.73863 ? 440  GLU   B CB  1 
ATOM   2713 C CG  . GLU   B 1 85  ? -17.53702 -32.83367 23.19187  1.000 38.06402 ? 440  GLU   B CG  1 
ATOM   2714 C CD  . GLU   B 1 85  ? -18.81739 -32.16923 23.65634  1.000 43.98380 ? 440  GLU   B CD  1 
ATOM   2715 O OE1 . GLU   B 1 85  ? -19.78893 -32.10475 22.85984  1.000 45.34660 ? 440  GLU   B OE1 1 
ATOM   2716 O OE2 . GLU   B 1 85  ? -18.83779 -31.69007 24.80448  1.000 51.08837 ? 440  GLU   B OE2 1 
ATOM   2717 N N   . ALA   B 1 86  ? -14.96269 -35.71371 22.53135  1.000 23.58475 ? 441  ALA   B N   1 
ATOM   2718 C CA  . ALA   B 1 86  ? -14.67247 -36.93648 23.25674  1.000 27.38354 ? 441  ALA   B CA  1 
ATOM   2719 C C   . ALA   B 1 86  ? -13.66160 -36.62748 24.33395  1.000 24.66211 ? 441  ALA   B C   1 
ATOM   2720 O O   . ALA   B 1 86  ? -13.84240 -35.66989 25.09902  1.000 29.05861 ? 441  ALA   B O   1 
ATOM   2721 C CB  . ALA   B 1 86  ? -14.17295 -38.03048 22.30408  1.000 29.12328 ? 441  ALA   B CB  1 
ATOM   2722 N N   . GLU   B 1 87  ? -12.57825 -37.40490 24.39972  1.000 29.41281 ? 442  GLU   B N   1 
ATOM   2723 C CA  . GLU   B 1 87  ? -11.62882 -37.14164 25.46663  1.000 34.21795 ? 442  GLU   B CA  1 
ATOM   2724 C C   . GLU   B 1 87  ? -11.11926 -35.70911 25.37433  1.000 36.30987 ? 442  GLU   B C   1 
ATOM   2725 O O   . GLU   B 1 87  ? -10.89709 -35.07032 26.40030  1.000 30.81206 ? 442  GLU   B O   1 
ATOM   2726 C CB  . GLU   B 1 87  ? -10.49903 -38.18901 25.45710  1.000 32.75721 ? 442  GLU   B CB  1 
ATOM   2727 C CG  . GLU   B 1 87  ? -9.60129  -38.24317 24.20046  1.000 40.19524 ? 442  GLU   B CG  1 
ATOM   2728 C CD  . GLU   B 1 87  ? -10.11032 -39.20698 23.13432  1.000 40.50615 ? 442  GLU   B CD  1 
ATOM   2729 O OE1 . GLU   B 1 87  ? -11.32751 -39.41819 23.07888  1.000 28.69539 ? 442  GLU   B OE1 1 
ATOM   2730 O OE2 . GLU   B 1 87  ? -9.30143  -39.75249 22.35099  1.000 40.94385 ? 442  GLU   B OE2 1 
ATOM   2731 N N   . SER   B 1 88  ? -11.02938 -35.15639 24.16078  1.000 28.93770 ? 443  SER   B N   1 
ATOM   2732 C CA  . SER   B 1 88  ? -10.87042 -33.72181 23.92467  1.000 28.58375 ? 443  SER   B CA  1 
ATOM   2733 C C   . SER   B 1 88  ? -11.73754 -33.36434 22.71617  1.000 21.92936 ? 443  SER   B C   1 
ATOM   2734 O O   . SER   B 1 88  ? -12.34309 -34.24634 22.11160  1.000 23.13523 ? 443  SER   B O   1 
ATOM   2735 C CB  . SER   B 1 88  ? -9.39657  -33.35579 23.69733  1.000 38.66610 ? 443  SER   B CB  1 
ATOM   2736 O OG  . SER   B 1 88  ? -9.24131  -31.96345 23.49693  1.000 50.18466 ? 443  SER   B OG  1 
ATOM   2737 N N   . TRP   B 1 89  ? -11.82923 -32.07208 22.38486  1.000 21.56103 ? 444  TRP   B N   1 
ATOM   2738 C CA  . TRP   B 1 89  ? -12.53842 -31.61438 21.18060  1.000 22.49603 ? 444  TRP   B CA  1 
ATOM   2739 C C   . TRP   B 1 89  ? -11.67619 -31.85745 19.96224  1.000 18.97960 ? 444  TRP   B C   1 
ATOM   2740 O O   . TRP   B 1 89  ? -10.47458 -31.58691 19.98913  1.000 22.39310 ? 444  TRP   B O   1 
ATOM   2741 C CB  . TRP   B 1 89  ? -12.85219 -30.11859 21.22963  1.000 27.45299 ? 444  TRP   B CB  1 
ATOM   2742 C CG  . TRP   B 1 89  ? -14.00477 -29.78525 22.06856  1.000 31.17329 ? 444  TRP   B CG  1 
ATOM   2743 C CD1 . TRP   B 1 89  ? -13.97234 -29.32793 23.34814  1.000 38.95191 ? 444  TRP   B CD1 1 
ATOM   2744 C CD2 . TRP   B 1 89  ? -15.37367 -29.84582 21.68585  1.000 30.23075 ? 444  TRP   B CD2 1 
ATOM   2745 N NE1 . TRP   B 1 89  ? -15.24881 -29.11609 23.78956  1.000 31.95059 ? 444  TRP   B NE1 1 
ATOM   2746 C CE2 . TRP   B 1 89  ? -16.12774 -29.41844 22.78484  1.000 34.53801 ? 444  TRP   B CE2 1 
ATOM   2747 C CE3 . TRP   B 1 89  ? -16.04062 -30.22809 20.52070  1.000 33.89458 ? 444  TRP   B CE3 1 
ATOM   2748 C CZ2 . TRP   B 1 89  ? -17.51630 -29.37570 22.76114  1.000 34.03007 ? 444  TRP   B CZ2 1 
ATOM   2749 C CZ3 . TRP   B 1 89  ? -17.41583 -30.17139 20.49195  1.000 39.03049 ? 444  TRP   B CZ3 1 
ATOM   2750 C CH2 . TRP   B 1 89  ? -18.14129 -29.74461 21.60551  1.000 39.76251 ? 444  TRP   B CH2 1 
ATOM   2751 N N   . MET   B 1 90  ? -12.29742 -32.38999 18.90072  1.000 16.97056 ? 445  MET   B N   1 
ATOM   2752 C CA  . MET   B 1 90  ? -11.57962 -32.82788 17.71596  1.000 16.29590 ? 445  MET   B CA  1 
ATOM   2753 C C   . MET   B 1 90  ? -12.27558 -32.37797 16.44273  1.000 15.31353 ? 445  MET   B C   1 
ATOM   2754 O O   . MET   B 1 90  ? -13.48069 -32.55672 16.28032  1.000 18.71220 ? 445  MET   B O   1 
ATOM   2755 C CB  . MET   B 1 90  ? -11.48276 -34.34521 17.68072  1.000 18.98697 ? 445  MET   B CB  1 
ATOM   2756 C CG  . MET   B 1 90  ? -10.83499 -34.91932 18.92324  1.000 17.17050 ? 445  MET   B CG  1 
ATOM   2757 S SD  . MET   B 1 90  ? -10.75197 -36.72105 18.79507  1.000 25.56136 ? 445  MET   B SD  1 
ATOM   2758 C CE  . MET   B 1 90  ? -12.38802 -37.02084 19.37045  1.000 31.39888 ? 445  MET   B CE  1 
ATOM   2759 N N   . LEU   B 1 91  ? -11.46682 -31.88139 15.49284  1.000 15.07106 ? 446  LEU   B N   1 
ATOM   2760 C CA  . LEU   B 1 91  ? -11.90583 -31.54951 14.13945  1.000 15.14963 ? 446  LEU   B CA  1 
ATOM   2761 C C   . LEU   B 1 91  ? -11.29691 -32.59660 13.20692  1.000 13.39104 ? 446  LEU   B C   1 
ATOM   2762 O O   . LEU   B 1 91  ? -10.06733 -32.68424 13.08048  1.000 12.81680 ? 446  LEU   B O   1 
ATOM   2763 C CB  . LEU   B 1 91  ? -11.46198 -30.11085 13.80578  1.000 15.18697 ? 446  LEU   B CB  1 
ATOM   2764 C CG  . LEU   B 1 91  ? -11.63936 -29.67668 12.34809  1.000 15.72902 ? 446  LEU   B CG  1 
ATOM   2765 C CD1 . LEU   B 1 91  ? -13.07606 -29.73681 11.94344  1.000 23.28611 ? 446  LEU   B CD1 1 
ATOM   2766 C CD2 . LEU   B 1 91  ? -11.05954 -28.28165 12.14314  1.000 19.91511 ? 446  LEU   B CD2 1 
ATOM   2767 N N   . VAL   B 1 92  ? -12.17032 -33.40278 12.59117  1.000 12.64279 ? 447  VAL   B N   1 
ATOM   2768 C CA  . VAL   B 1 92  ? -11.75234 -34.53490 11.74635  1.000 13.64034 ? 447  VAL   B CA  1 
ATOM   2769 C C   . VAL   B 1 92  ? -11.86045 -34.12815 10.28383  1.000 12.35954 ? 447  VAL   B C   1 
ATOM   2770 O O   . VAL   B 1 92  ? -12.91147 -33.67477 9.84589   1.000 13.78485 ? 447  VAL   B O   1 
ATOM   2771 C CB  . VAL   B 1 92  ? -12.63753 -35.76601 12.01977  1.000 13.84203 ? 447  VAL   B CB  1 
ATOM   2772 C CG1 . VAL   B 1 92  ? -12.23022 -36.93084 11.13918  1.000 15.26082 ? 447  VAL   B CG1 1 
ATOM   2773 C CG2 . VAL   B 1 92  ? -12.52537 -36.22226 13.48947  1.000 15.49452 ? 447  VAL   B CG2 1 
ATOM   2774 N N   . MET   B 1 93  ? -10.75340 -34.25876 9.55930   1.000 13.03431 ? 448  MET   B N   1 
ATOM   2775 C CA  . MET   B 1 93  ? -10.65055 -33.79302 8.17133   1.000 12.54248 ? 448  MET   B CA  1 
ATOM   2776 C C   . MET   B 1 93  ? -10.12749 -34.92420 7.28804   1.000 10.35907 ? 448  MET   B C   1 
ATOM   2777 O O   . MET   B 1 93  ? -9.42560  -35.80185 7.74629   1.000 12.32401 ? 448  MET   B O   1 
ATOM   2778 C CB  . MET   B 1 93  ? -9.68872  -32.59817 8.06714   1.000 14.34116 ? 448  MET   B CB  1 
ATOM   2779 C CG  . MET   B 1 93  ? -10.23671 -31.35566 8.74128   1.000 14.52264 ? 448  MET   B CG  1 
ATOM   2780 S SD  . MET   B 1 93  ? -8.95803  -30.16920 9.18254   1.000 15.33792 ? 448  MET   B SD  1 
ATOM   2781 C CE  . MET   B 1 93  ? -8.06272  -31.04013 10.49460  1.000 16.97104 ? 448  MET   B CE  1 
ATOM   2782 N N   . GLU   B 1 94  ? -10.40260 -34.82842 5.97857   1.000 12.32736 ? 449  GLU   B N   1 
ATOM   2783 C CA  . GLU   B 1 94  ? -9.75771  -35.76706 5.05125   1.000 13.08073 ? 449  GLU   B CA  1 
ATOM   2784 C C   . GLU   B 1 94  ? -8.24303  -35.53802 5.10835   1.000 14.12786 ? 449  GLU   B C   1 
ATOM   2785 O O   . GLU   B 1 94  ? -7.80222  -34.39749 5.20007   1.000 17.88114 ? 449  GLU   B O   1 
ATOM   2786 C CB  . GLU   B 1 94  ? -10.22289 -35.55060 3.61463   1.000 16.40365 ? 449  GLU   B CB  1 
ATOM   2787 C CG  . GLU   B 1 94  ? -10.23613 -34.13581 3.23696   1.000 30.45039 ? 449  GLU   B CG  1 
ATOM   2788 C CD  . GLU   B 1 94  ? -10.47235 -33.91584 1.77041   1.000 38.37503 ? 449  GLU   B CD  1 
ATOM   2789 O OE1 . GLU   B 1 94  ? -11.09797 -34.79338 1.09890   1.000 34.77812 ? 449  GLU   B OE1 1 
ATOM   2790 O OE2 . GLU   B 1 94  ? -10.02393 -32.83787 1.33102   1.000 19.71045 ? 449  GLU   B OE2 1 
ATOM   2791 N N   . MET   B 1 95  ? -7.46632  -36.61653 5.07758   1.000 13.20087 ? 450  MET   B N   1 
ATOM   2792 C CA  . MET   B 1 95  ? -6.00151  -36.52102 5.20506   1.000 13.29471 ? 450  MET   B CA  1 
ATOM   2793 C C   . MET   B 1 95  ? -5.35454  -36.09378 3.88053   1.000 15.01423 ? 450  MET   B C   1 
ATOM   2794 O O   . MET   B 1 95  ? -5.57454  -36.72942 2.83967   1.000 15.95084 ? 450  MET   B O   1 
ATOM   2795 C CB  . MET   B 1 95  ? -5.44964  -37.88452 5.64282   1.000 14.99419 ? 450  MET   B CB  1 
ATOM   2796 C CG  . MET   B 1 95  ? -3.91625  -38.02640 5.51800   1.000 16.38238 ? 450  MET   B CG  1 
ATOM   2797 S SD  . MET   B 1 95  ? -3.07253  -36.91475 6.64425   1.000 15.56084 ? 450  MET   B SD  1 
ATOM   2798 C CE  . MET   B 1 95  ? -3.24767  -37.75912 8.22101   1.000 19.34021 ? 450  MET   B CE  1 
ATOM   2799 N N   . ALA   B 1 96  ? -4.52575  -35.06411 3.94895   1.000 14.27761 ? 451  ALA   B N   1 
ATOM   2800 C CA  . ALA   B 1 96  ? -3.58784  -34.70295 2.87445   1.000 12.95432 ? 451  ALA   B CA  1 
ATOM   2801 C C   . ALA   B 1 96  ? -2.23990  -35.31319 3.28478   1.000 9.95056  ? 451  ALA   B C   1 
ATOM   2802 O O   . ALA   B 1 96  ? -1.53476  -34.79051 4.15538   1.000 12.84509 ? 451  ALA   B O   1 
ATOM   2803 C CB  . ALA   B 1 96  ? -3.51026  -33.18263 2.72060   1.000 14.29262 ? 451  ALA   B CB  1 
ATOM   2804 N N   . GLU   B 1 97  ? -1.86130  -36.43862 2.64321   1.000 12.56835 ? 452  GLU   B N   1 
ATOM   2805 C CA  . GLU   B 1 97  ? -0.78080  -37.27387 3.16877   1.000 13.16561 ? 452  GLU   B CA  1 
ATOM   2806 C C   . GLU   B 1 97  ? 0.59764   -36.64403 3.12983   1.000 11.35665 ? 452  GLU   B C   1 
ATOM   2807 O O   . GLU   B 1 97  ? 1.46191   -37.01447 3.94484   1.000 15.38576 ? 452  GLU   B O   1 
ATOM   2808 C CB  . GLU   B 1 97  ? -0.70518  -38.59134 2.37673   1.000 14.65472 ? 452  GLU   B CB  1 
ATOM   2809 C CG  . GLU   B 1 97  ? -1.93589  -39.44383 2.53391   1.000 14.67715 ? 452  GLU   B CG  1 
ATOM   2810 C CD  . GLU   B 1 97  ? -1.91376  -40.26291 3.81907   1.000 16.13828 ? 452  GLU   B CD  1 
ATOM   2811 O OE1 . GLU   B 1 97  ? -0.99766  -40.15063 4.64968   1.000 19.76123 ? 452  GLU   B OE1 1 
ATOM   2812 O OE2 . GLU   B 1 97  ? -2.88154  -41.05333 4.02981   1.000 18.23679 ? 452  GLU   B OE2 1 
ATOM   2813 N N   . LEU   B 1 98  ? 0.83201   -35.69519 2.20653   1.000 13.06233 ? 453  LEU   B N   1 
ATOM   2814 C CA  . LEU   B 1 98  ? 2.18883   -35.15308 2.12852   1.000 14.36833 ? 453  LEU   B CA  1 
ATOM   2815 C C   . LEU   B 1 98  ? 2.42760   -33.93965 3.01581   1.000 15.61506 ? 453  LEU   B C   1 
ATOM   2816 O O   . LEU   B 1 98  ? 3.59880   -33.52942 3.15317   1.000 16.02137 ? 453  LEU   B O   1 
ATOM   2817 C CB  . LEU   B 1 98  ? 2.58090   -34.80227 0.68575   1.000 14.29136 ? 453  LEU   B CB  1 
ATOM   2818 C CG  . LEU   B 1 98  ? 3.01479   -35.98692 -0.20992  1.000 15.97499 ? 453  LEU   B CG  1 
ATOM   2819 C CD1 . LEU   B 1 98  ? 2.00702   -37.13335 -0.20013  1.000 16.47636 ? 453  LEU   B CD1 1 
ATOM   2820 C CD2 . LEU   B 1 98  ? 3.22068   -35.44325 -1.61088  1.000 16.53168 ? 453  LEU   B CD2 1 
ATOM   2821 N N   . GLY   B 1 99  ? 1.39082   -33.41366 3.68411   1.000 15.05613 ? 454  GLY   B N   1 
ATOM   2822 C CA  . GLY   B 1 99  ? 1.60028   -32.41910 4.72079   1.000 15.12280 ? 454  GLY   B CA  1 
ATOM   2823 C C   . GLY   B 1 99  ? 1.78409   -31.02028 4.16041   1.000 12.88132 ? 454  GLY   B C   1 
ATOM   2824 O O   . GLY   B 1 99  ? 1.55725   -30.74295 2.98952   1.000 13.44799 ? 454  GLY   B O   1 
ATOM   2825 N N   . PRO   B 1 100 ? 2.22066   -30.10873 5.02182   1.000 13.18727 ? 455  PRO   B N   1 
ATOM   2826 C CA  . PRO   B 1 100 ? 2.35249   -28.69353 4.63684   1.000 13.55141 ? 455  PRO   B CA  1 
ATOM   2827 C C   . PRO   B 1 100 ? 3.34935   -28.46566 3.52097   1.000 14.40857 ? 455  PRO   B C   1 
ATOM   2828 O O   . PRO   B 1 100 ? 4.44631   -29.05743 3.47971   1.000 14.12625 ? 455  PRO   B O   1 
ATOM   2829 C CB  . PRO   B 1 100 ? 2.80761   -28.02418 5.94376   1.000 13.46849 ? 455  PRO   B CB  1 
ATOM   2830 C CG  . PRO   B 1 100 ? 2.20519   -28.86835 7.01632   1.000 16.50607 ? 455  PRO   B CG  1 
ATOM   2831 C CD  . PRO   B 1 100 ? 2.32945   -30.30009 6.47712   1.000 15.75293 ? 455  PRO   B CD  1 
ATOM   2832 N N   . LEU   B 1 101 ? 2.95193   -27.57733 2.60105   1.000 12.19001 ? 456  LEU   B N   1 
ATOM   2833 C CA  . LEU   B 1 101 ? 3.73477   -27.25926 1.41252   1.000 10.58744 ? 456  LEU   B CA  1 
ATOM   2834 C C   . LEU   B 1 101 ? 5.12128   -26.71322 1.73354   1.000 13.61492 ? 456  LEU   B C   1 
ATOM   2835 O O   . LEU   B 1 101 ? 6.07932   -27.02309 1.00575   1.000 14.93132 ? 456  LEU   B O   1 
ATOM   2836 C CB  . LEU   B 1 101 ? 2.94506   -26.24667 0.57844   1.000 12.98328 ? 456  LEU   B CB  1 
ATOM   2837 C CG  . LEU   B 1 101 ? 3.62169   -25.69502 -0.68618  1.000 13.44928 ? 456  LEU   B CG  1 
ATOM   2838 C CD1 . LEU   B 1 101 ? 3.92453   -26.80891 -1.72930  1.000 15.01814 ? 456  LEU   B CD1 1 
ATOM   2839 C CD2 . LEU   B 1 101 ? 2.86156   -24.47350 -1.29493  1.000 14.49635 ? 456  LEU   B CD2 1 
ATOM   2840 N N   . ASN   B 1 102 ? 5.22595   -25.80588 2.70084   1.000 12.95023 ? 457  ASN   B N   1 
ATOM   2841 C CA  . ASN   B 1 102 ? 6.54347   -25.22720 2.96124   1.000 14.23213 ? 457  ASN   B CA  1 
ATOM   2842 C C   . ASN   B 1 102 ? 7.52797   -26.29998 3.40416   1.000 14.76416 ? 457  ASN   B C   1 
ATOM   2843 O O   . ASN   B 1 102 ? 8.64737   -26.34519 2.89170   1.000 16.05419 ? 457  ASN   B O   1 
ATOM   2844 C CB  . ASN   B 1 102 ? 6.48692   -24.07721 4.00224   1.000 14.35587 ? 457  ASN   B CB  1 
ATOM   2845 C CG  . ASN   B 1 102 ? 5.96731   -24.49223 5.35456   1.000 14.80682 ? 457  ASN   B CG  1 
ATOM   2846 O OD1 . ASN   B 1 102 ? 5.16897   -25.41807 5.53112   1.000 15.99780 ? 457  ASN   B OD1 1 
ATOM   2847 N ND2 . ASN   B 1 102 ? 6.38293   -23.73410 6.38051   1.000 19.51838 ? 457  ASN   B ND2 1 
ATOM   2848 N N   . LYS   B 1 103 ? 7.12001   -27.17996 4.31490   1.000 14.48817 ? 458  LYS   B N   1 
ATOM   2849 C CA  . LYS   B 1 103 ? 8.00863   -28.25522 4.75602   1.000 14.60063 ? 458  LYS   B CA  1 
ATOM   2850 C C   . LYS   B 1 103 ? 8.31267   -29.21891 3.62556   1.000 14.91573 ? 458  LYS   B C   1 
ATOM   2851 O O   . LYS   B 1 103 ? 9.45686   -29.66564 3.48717   1.000 17.86321 ? 458  LYS   B O   1 
ATOM   2852 C CB  . LYS   B 1 103 ? 7.37129   -28.99208 5.93603   1.000 16.22834 ? 458  LYS   B CB  1 
ATOM   2853 C CG  . LYS   B 1 103 ? 8.30974   -30.05666 6.58980   1.000 25.08565 ? 458  LYS   B CG  1 
ATOM   2854 C CD  . LYS   B 1 103 ? 9.48172   -29.41950 7.31779   1.000 35.02592 ? 458  LYS   B CD  1 
ATOM   2855 C CE  . LYS   B 1 103 ? 10.20031  -30.44990 8.18942   1.000 46.36956 ? 458  LYS   B CE  1 
ATOM   2856 N NZ  . LYS   B 1 103 ? 11.27708  -29.80604 8.99737   1.000 54.13388 ? 458  LYS   B NZ  1 
ATOM   2857 N N   . TYR   B 1 104 ? 7.31684   -29.54438 2.78299   1.000 14.81518 ? 459  TYR   B N   1 
ATOM   2858 C CA  . TYR   B 1 104 ? 7.56066   -30.45905 1.67538   1.000 16.41617 ? 459  TYR   B CA  1 
ATOM   2859 C C   . TYR   B 1 104 ? 8.59940   -29.89422 0.73321   1.000 17.22440 ? 459  TYR   B C   1 
ATOM   2860 O O   . TYR   B 1 104 ? 9.49010   -30.61700 0.29235   1.000 17.06365 ? 459  TYR   B O   1 
ATOM   2861 C CB  . TYR   B 1 104 ? 6.25160   -30.74426 0.90933   1.000 13.48852 ? 459  TYR   B CB  1 
ATOM   2862 C CG  . TYR   B 1 104 ? 6.43926   -31.77570 -0.20481  1.000 14.77522 ? 459  TYR   B CG  1 
ATOM   2863 C CD1 . TYR   B 1 104 ? 6.35064   -33.12606 0.10793   1.000 16.70126 ? 459  TYR   B CD1 1 
ATOM   2864 C CD2 . TYR   B 1 104 ? 6.75823   -31.40590 -1.51781  1.000 17.76965 ? 459  TYR   B CD2 1 
ATOM   2865 C CE1 . TYR   B 1 104 ? 6.53952   -34.09501 -0.88235  1.000 16.57315 ? 459  TYR   B CE1 1 
ATOM   2866 C CE2 . TYR   B 1 104 ? 6.97280   -32.38741 -2.49304  1.000 20.98018 ? 459  TYR   B CE2 1 
ATOM   2867 C CZ  . TYR   B 1 104 ? 6.84712   -33.70314 -2.14766  1.000 21.96873 ? 459  TYR   B CZ  1 
ATOM   2868 O OH  . TYR   B 1 104 ? 7.03051   -34.68734 -3.09630  1.000 23.81311 ? 459  TYR   B OH  1 
ATOM   2869 N N   . LEU   B 1 105 ? 8.51724   -28.59462 0.42792   1.000 13.00129 ? 460  LEU   B N   1 
ATOM   2870 C CA  . LEU   B 1 105 ? 9.47251   -28.01647 -0.50951  1.000 15.10896 ? 460  LEU   B CA  1 
ATOM   2871 C C   . LEU   B 1 105 ? 10.84938  -27.87996 0.13931   1.000 15.63820 ? 460  LEU   B C   1 
ATOM   2872 O O   . LEU   B 1 105 ? 11.85209  -28.03628 -0.55080  1.000 18.13951 ? 460  LEU   B O   1 
ATOM   2873 C CB  . LEU   B 1 105 ? 8.93777   -26.66556 -1.07414  1.000 14.05128 ? 460  LEU   B CB  1 
ATOM   2874 C CG  . LEU   B 1 105 ? 7.69389   -26.74603 -1.98874  1.000 15.01506 ? 460  LEU   B CG  1 
ATOM   2875 C CD1 . LEU   B 1 105 ? 7.24516   -25.31588 -2.30984  1.000 16.06665 ? 460  LEU   B CD1 1 
ATOM   2876 C CD2 . LEU   B 1 105 ? 8.00298   -27.48091 -3.29670  1.000 18.66767 ? 460  LEU   B CD2 1 
ATOM   2877 N N   . GLN   B 1 106 ? 10.91337  -27.60447 1.44192   1.000 17.33932 ? 461  GLN   B N   1 
ATOM   2878 C CA  . GLN   B 1 106 ? 12.20738  -27.62761 2.13400   1.000 16.79179 ? 461  GLN   B CA  1 
ATOM   2879 C C   . GLN   B 1 106 ? 12.89236  -28.98266 2.00027   1.000 21.37162 ? 461  GLN   B C   1 
ATOM   2880 O O   . GLN   B 1 106 ? 14.12608  -29.05089 1.97034   1.000 21.46290 ? 461  GLN   B O   1 
ATOM   2881 C CB  . GLN   B 1 106 ? 12.04661  -27.33189 3.60764   1.000 18.45437 ? 461  GLN   B CB  1 
ATOM   2882 C CG  . GLN   B 1 106 ? 11.66998  -25.85859 3.91750   1.000 18.04020 ? 461  GLN   B CG  1 
ATOM   2883 C CD  . GLN   B 1 106 ? 11.08628  -25.72315 5.31979   1.000 23.21514 ? 461  GLN   B CD  1 
ATOM   2884 O OE1 . GLN   B 1 106 ? 11.16130  -26.64048 6.13771   1.000 28.11638 ? 461  GLN   B OE1 1 
ATOM   2885 N NE2 . GLN   B 1 106 ? 10.48958  -24.57082 5.59913   1.000 21.79658 ? 461  GLN   B NE2 1 
ATOM   2886 N N   . GLN   B 1 107 ? 12.12096  -30.06544 2.05178   1.000 17.43786 ? 462  GLN   B N   1 
ATOM   2887 C CA  . GLN   B 1 107 ? 12.64817  -31.43242 2.00739   1.000 17.02789 ? 462  GLN   B CA  1 
ATOM   2888 C C   . GLN   B 1 107 ? 12.83927  -31.95476 0.59402   1.000 23.16491 ? 462  GLN   B C   1 
ATOM   2889 O O   . GLN   B 1 107 ? 13.36056  -33.07791 0.44102   1.000 23.07394 ? 462  GLN   B O   1 
ATOM   2890 C CB  . GLN   B 1 107 ? 11.71469  -32.37509 2.72916   1.000 20.84226 ? 462  GLN   B CB  1 
ATOM   2891 C CG  . GLN   B 1 107 ? 11.54182  -32.05959 4.19344   1.000 24.81092 ? 462  GLN   B CG  1 
ATOM   2892 C CD  . GLN   B 1 107 ? 12.71041  -32.45879 5.05601   1.000 48.50829 ? 462  GLN   B CD  1 
ATOM   2893 O OE1 . GLN   B 1 107 ? 13.42170  -31.60430 5.57567   1.000 41.63924 ? 462  GLN   B OE1 1 
ATOM   2894 N NE2 . GLN   B 1 107 ? 12.90709  -33.76448 5.22894   1.000 50.30966 ? 462  GLN   B NE2 1 
ATOM   2895 N N   . ASN   B 1 108 ? 12.39703  -31.20972 -0.44294  1.000 19.23753 ? 463  ASN   B N   1 
ATOM   2896 C CA  . ASN   B 1 108 ? 12.30368  -31.68719 -1.83412  1.000 17.59016 ? 463  ASN   B CA  1 
ATOM   2897 C C   . ASN   B 1 108 ? 12.68623  -30.52093 -2.71532  1.000 21.30251 ? 463  ASN   B C   1 
ATOM   2898 O O   . ASN   B 1 108 ? 11.89011  -29.94021 -3.49049  1.000 20.15943 ? 463  ASN   B O   1 
ATOM   2899 C CB  . ASN   B 1 108 ? 10.91890  -32.23286 -2.18812  1.000 18.32512 ? 463  ASN   B CB  1 
ATOM   2900 C CG  . ASN   B 1 108 ? 10.60894  -33.47680 -1.41654  1.000 22.63137 ? 463  ASN   B CG  1 
ATOM   2901 O OD1 . ASN   B 1 108 ? 11.11658  -34.56488 -1.74782  1.000 27.19755 ? 463  ASN   B OD1 1 
ATOM   2902 N ND2 . ASN   B 1 108 ? 9.81455   -33.35515 -0.36943  1.000 18.54792 ? 463  ASN   B ND2 1 
ATOM   2903 N N   . ARG   B 1 109 ? 13.95530  -30.14481 -2.58997  1.000 20.31735 ? 464  ARG   B N   1 
ATOM   2904 C CA  . ARG   B 1 109 ? 14.45853  -28.92574 -3.21268  1.000 22.60547 ? 464  ARG   B CA  1 
ATOM   2905 C C   . ARG   B 1 109 ? 14.58314  -29.01655 -4.72274  1.000 22.43168 ? 464  ARG   B C   1 
ATOM   2906 O O   . ARG   B 1 109 ? 14.86451  -27.98593 -5.36074  1.000 30.83697 ? 464  ARG   B O   1 
ATOM   2907 C CB  . ARG   B 1 109 ? 15.83290  -28.57071 -2.62136  1.000 27.31416 ? 464  ARG   B CB  1 
ATOM   2908 C CG  . ARG   B 1 109 ? 15.81956  -28.48033 -1.14120  1.000 35.14408 ? 464  ARG   B CG  1 
ATOM   2909 C CD  . ARG   B 1 109 ? 15.03361  -27.28413 -0.72164  1.000 36.59245 ? 464  ARG   B CD  1 
ATOM   2910 N NE  . ARG   B 1 109 ? 15.86048  -26.10184 -0.50301  1.000 50.91792 ? 464  ARG   B NE  1 
ATOM   2911 C CZ  . ARG   B 1 109 ? 16.18519  -25.22924 -1.44843  1.000 39.75676 ? 464  ARG   B CZ  1 
ATOM   2912 N NH1 . ARG   B 1 109 ? 15.86544  -25.43113 -2.71878  1.000 42.19391 ? 464  ARG   B NH1 1 
ATOM   2913 N NH2 . ARG   B 1 109 ? 16.84080  -24.12350 -1.11239  1.000 47.35779 ? 464  ARG   B NH2 1 
ATOM   2914 N N   . HIS   B 1 110 ? 14.37728  -30.19061 -5.31834  1.000 23.24191 ? 465  HIS   B N   1 
ATOM   2915 C CA  . HIS   B 1 110 ? 14.47194  -30.33687 -6.76426  1.000 24.72004 ? 465  HIS   B CA  1 
ATOM   2916 C C   . HIS   B 1 110 ? 13.11060  -30.43646 -7.46301  1.000 24.67447 ? 465  HIS   B C   1 
ATOM   2917 O O   . HIS   B 1 110 ? 13.07260  -30.74801 -8.64909  1.000 26.04160 ? 465  HIS   B O   1 
ATOM   2918 C CB  . HIS   B 1 110 ? 15.32778  -31.55927 -7.10280  1.000 38.01438 ? 465  HIS   B CB  1 
ATOM   2919 C CG  . HIS   B 1 110 ? 16.77829  -31.38127 -6.77603  1.000 49.58085 ? 465  HIS   B CG  1 
ATOM   2920 N ND1 . HIS   B 1 110 ? 17.21260  -30.83069 -5.58827  1.000 45.63173 ? 465  HIS   B ND1 1 
ATOM   2921 C CD2 . HIS   B 1 110 ? 17.89472  -31.66810 -7.48736  1.000 56.29200 ? 465  HIS   B CD2 1 
ATOM   2922 C CE1 . HIS   B 1 110 ? 18.53348  -30.79750 -5.57479  1.000 54.35719 ? 465  HIS   B CE1 1 
ATOM   2923 N NE2 . HIS   B 1 110 ? 18.97224  -31.29983 -6.71610  1.000 61.45177 ? 465  HIS   B NE2 1 
ATOM   2924 N N   . VAL   B 1 111 ? 11.99786  -30.16583 -6.75759  1.000 19.45657 ? 466  VAL   B N   1 
ATOM   2925 C CA  . VAL   B 1 111 ? 10.70289  -30.03543 -7.39842  1.000 18.97195 ? 466  VAL   B CA  1 
ATOM   2926 C C   . VAL   B 1 111 ? 10.84920  -29.01582 -8.50466  1.000 21.64102 ? 466  VAL   B C   1 
ATOM   2927 O O   . VAL   B 1 111 ? 11.49069  -27.97368 -8.32305  1.000 22.00801 ? 466  VAL   B O   1 
ATOM   2928 C CB  . VAL   B 1 111 ? 9.64105   -29.60302 -6.36557  1.000 17.85904 ? 466  VAL   B CB  1 
ATOM   2929 C CG1 . VAL   B 1 111 ? 8.32855   -29.14311 -7.03519  1.000 19.32328 ? 466  VAL   B CG1 1 
ATOM   2930 C CG2 . VAL   B 1 111 ? 9.37575   -30.76414 -5.39825  1.000 16.40289 ? 466  VAL   B CG2 1 
ATOM   2931 N N   . LYS   B 1 112 ? 10.24358  -29.29056 -9.65410  1.000 17.54662 ? 467  LYS   B N   1 
ATOM   2932 C CA  . LYS   B 1 112 ? 10.53692  -28.46266 -10.79805 1.000 21.26763 ? 467  LYS   B CA  1 
ATOM   2933 C C   . LYS   B 1 112 ? 9.71109   -27.18494 -10.77911 1.000 18.22646 ? 467  LYS   B C   1 
ATOM   2934 O O   . LYS   B 1 112 ? 8.60909   -27.12075 -10.19030 1.000 17.51242 ? 467  LYS   B O   1 
ATOM   2935 C CB  . LYS   B 1 112 ? 10.28743  -29.23404 -12.08596 1.000 24.15062 ? 467  LYS   B CB  1 
ATOM   2936 C CG  . LYS   B 1 112 ? 11.20252  -30.44859 -12.22292 1.000 25.49137 ? 467  LYS   B CG  1 
ATOM   2937 C CD  . LYS   B 1 112 ? 11.00585  -31.12983 -13.56011 1.000 49.58682 ? 467  LYS   B CD  1 
ATOM   2938 C CE  . LYS   B 1 112 ? 11.86946  -32.38539 -13.66374 1.000 56.25214 ? 467  LYS   B CE  1 
ATOM   2939 N NZ  . LYS   B 1 112 ? 11.43370  -33.43596 -12.69562 1.000 52.45907 ? 467  LYS   B NZ  1 
ATOM   2940 N N   . ASP   B 1 113 ? 10.24185  -26.13186 -11.41172 1.000 19.07343 ? 468  ASP   B N   1 
ATOM   2941 C CA  . ASP   B 1 113 ? 9.47134   -24.89728 -11.47203 1.000 18.18095 ? 468  ASP   B CA  1 
ATOM   2942 C C   . ASP   B 1 113 ? 8.04791   -25.09468 -12.02459 1.000 18.08885 ? 468  ASP   B C   1 
ATOM   2943 O O   . ASP   B 1 113 ? 7.08508   -24.51249 -11.52219 1.000 16.14993 ? 468  ASP   B O   1 
ATOM   2944 C CB  . ASP   B 1 113 ? 10.21675  -23.84931 -12.31676 1.000 16.41080 ? 468  ASP   B CB  1 
ATOM   2945 C CG  . ASP   B 1 113 ? 9.57535   -22.48963 -12.22854 1.000 22.10533 ? 468  ASP   B CG  1 
ATOM   2946 O OD1 . ASP   B 1 113 ? 9.73676   -21.83344 -11.16044 1.000 25.28271 ? 468  ASP   B OD1 1 
ATOM   2947 O OD2 . ASP   B 1 113 ? 8.94036   -22.08320 -13.20639 1.000 26.12998 ? 468  ASP   B OD2 1 
ATOM   2948 N N   . LYS   B 1 114 ? 7.87359   -25.89282 -13.07345 1.000 17.97449 ? 469  LYS   B N   1 
ATOM   2949 C CA  . LYS   B 1 114 ? 6.53999   -26.07389 -13.61417 1.000 16.09077 ? 469  LYS   B CA  1 
ATOM   2950 C C   . LYS   B 1 114 ? 5.59460   -26.65836 -12.55762 1.000 16.13025 ? 469  LYS   B C   1 
ATOM   2951 O O   . LYS   B 1 114 ? 4.40481   -26.33719 -12.51558 1.000 16.75231 ? 469  LYS   B O   1 
ATOM   2952 C CB  . LYS   B 1 114 ? 6.66165   -27.01332 -14.83571 1.000 20.07006 ? 469  LYS   B CB  1 
ATOM   2953 C CG  . LYS   B 1 114 ? 5.38819   -27.37747 -15.57133 1.000 27.80285 ? 469  LYS   B CG  1 
ATOM   2954 C CD  . LYS   B 1 114 ? 5.73137   -28.51187 -16.60241 1.000 31.21211 ? 469  LYS   B CD  1 
ATOM   2955 C CE  . LYS   B 1 114 ? 4.49987   -29.25058 -17.07239 1.000 43.24497 ? 469  LYS   B CE  1 
ATOM   2956 N NZ  . LYS   B 1 114 ? 4.89661   -30.35170 -17.99927 1.000 52.41667 ? 469  LYS   B NZ  1 
ATOM   2957 N N   . ASN   B 1 115 ? 6.12393   -27.55022 -11.71350 1.000 14.75464 ? 470  ASN   B N   1 
ATOM   2958 C CA  . ASN   B 1 115 ? 5.34829   -28.16627 -10.63585 1.000 16.74365 ? 470  ASN   B CA  1 
ATOM   2959 C C   . ASN   B 1 115 ? 4.93575   -27.11563 -9.60291  1.000 15.78573 ? 470  ASN   B C   1 
ATOM   2960 O O   . ASN   B 1 115 ? 3.81556   -27.14724 -9.07082  1.000 14.06164 ? 470  ASN   B O   1 
ATOM   2961 C CB  . ASN   B 1 115 ? 6.24733   -29.22523 -10.01060 1.000 15.88388 ? 470  ASN   B CB  1 
ATOM   2962 C CG  . ASN   B 1 115 ? 5.51863   -30.28900 -9.16258  1.000 19.26125 ? 470  ASN   B CG  1 
ATOM   2963 O OD1 . ASN   B 1 115 ? 6.12869   -31.33058 -8.87448  1.000 20.45340 ? 470  ASN   B OD1 1 
ATOM   2964 N ND2 . ASN   B 1 115 ? 4.27823   -30.00998 -8.70890  1.000 15.45152 ? 470  ASN   B ND2 1 
ATOM   2965 N N   . ILE   B 1 116 ? 5.83500   -26.19593 -9.28637  1.000 14.06361 ? 471  ILE   B N   1 
ATOM   2966 C CA  . ILE   B 1 116 ? 5.47619   -25.11519 -8.35173  1.000 13.32682 ? 471  ILE   B CA  1 
ATOM   2967 C C   . ILE   B 1 116 ? 4.35760   -24.27348 -8.93744  1.000 14.05331 ? 471  ILE   B C   1 
ATOM   2968 O O   . ILE   B 1 116 ? 3.39318   -23.91611 -8.24113  1.000 13.07085 ? 471  ILE   B O   1 
ATOM   2969 C CB  . ILE   B 1 116 ? 6.70328   -24.26013 -8.02582  1.000 13.32550 ? 471  ILE   B CB  1 
ATOM   2970 C CG1 . ILE   B 1 116 ? 7.75230   -25.10996 -7.35919  1.000 15.67530 ? 471  ILE   B CG1 1 
ATOM   2971 C CG2 . ILE   B 1 116 ? 6.31097   -23.08554 -7.09239  1.000 14.44008 ? 471  ILE   B CG2 1 
ATOM   2972 C CD1 . ILE   B 1 116 ? 9.11619   -24.46484 -7.23650  1.000 23.55418 ? 471  ILE   B CD1 1 
ATOM   2973 N N   . ILE   B 1 117 ? 4.45349   -23.92414 -10.22857 1.000 11.56996 ? 472  ILE   B N   1 
ATOM   2974 C CA  . ILE   B 1 117 ? 3.38662   -23.16732 -10.87166 1.000 12.33108 ? 472  ILE   B CA  1 
ATOM   2975 C C   . ILE   B 1 117 ? 2.05963   -23.91493 -10.78245 1.000 14.58113 ? 472  ILE   B C   1 
ATOM   2976 O O   . ILE   B 1 117 ? 1.02765   -23.32967 -10.45990 1.000 14.87409 ? 472  ILE   B O   1 
ATOM   2977 C CB  . ILE   B 1 117 ? 3.75364   -22.85633 -12.34563 1.000 14.57640 ? 472  ILE   B CB  1 
ATOM   2978 C CG1 . ILE   B 1 117 ? 4.96413   -21.92855 -12.38050 1.000 18.22309 ? 472  ILE   B CG1 1 
ATOM   2979 C CG2 . ILE   B 1 117 ? 2.55120   -22.24110 -13.02156 1.000 14.90891 ? 472  ILE   B CG2 1 
ATOM   2980 C CD1 . ILE   B 1 117 ? 5.72881   -22.00020 -13.71989 1.000 20.38232 ? 472  ILE   B CD1 1 
ATOM   2981 N N   . GLU   B 1 118 ? 2.06796   -25.21543 -11.10057 1.000 14.22161 ? 473  GLU   B N   1 
ATOM   2982 C CA  . GLU   B 1 118 ? 0.86004   -26.04351 -10.97094 1.000 13.48573 ? 473  GLU   B CA  1 
ATOM   2983 C C   . GLU   B 1 118 ? 0.21031   -25.91423 -9.59341  1.000 14.96859 ? 473  GLU   B C   1 
ATOM   2984 O O   . GLU   B 1 118 ? -1.00424  -25.72433 -9.49104  1.000 14.95695 ? 473  GLU   B O   1 
ATOM   2985 C CB  . GLU   B 1 118 ? 1.24648   -27.49903 -11.20790 1.000 14.29147 ? 473  GLU   B CB  1 
ATOM   2986 C CG  . GLU   B 1 118 ? 0.06869   -28.49968 -11.14667 1.000 16.52632 ? 473  GLU   B CG  1 
ATOM   2987 C CD  . GLU   B 1 118 ? 0.56189   -29.91349 -11.37790 1.000 25.83770 ? 473  GLU   B CD  1 
ATOM   2988 O OE1 . GLU   B 1 118 ? 1.73417   -30.21385 -11.03245 1.000 22.64607 ? 473  GLU   B OE1 1 
ATOM   2989 O OE2 . GLU   B 1 118 ? -0.24115  -30.72311 -11.85568 1.000 24.81691 ? 473  GLU   B OE2 1 
ATOM   2990 N N   . LEU   B 1 119 ? 1.01326   -26.07061 -8.53414  1.000 12.23413 ? 474  LEU   B N   1 
ATOM   2991 C CA  . LEU   B 1 119 ? 0.48297   -26.04636 -7.17052  1.000 11.69498 ? 474  LEU   B CA  1 
ATOM   2992 C C   . LEU   B 1 119 ? -0.04701  -24.65306 -6.81312  1.000 13.46227 ? 474  LEU   B C   1 
ATOM   2993 O O   . LEU   B 1 119 ? -1.12925  -24.54624 -6.22034  1.000 13.17883 ? 474  LEU   B O   1 
ATOM   2994 C CB  . LEU   B 1 119 ? 1.58482   -26.47450 -6.22906  1.000 12.37988 ? 474  LEU   B CB  1 
ATOM   2995 C CG  . LEU   B 1 119 ? 2.01355   -27.94033 -6.39802  1.000 12.81695 ? 474  LEU   B CG  1 
ATOM   2996 C CD1 . LEU   B 1 119 ? 3.23201   -28.19936 -5.56492  1.000 12.89366 ? 474  LEU   B CD1 1 
ATOM   2997 C CD2 . LEU   B 1 119 ? 0.87163   -28.91443 -6.01304  1.000 15.07236 ? 474  LEU   B CD2 1 
ATOM   2998 N N   . VAL   B 1 120 ? 0.70029   -23.56937 -7.12433  1.000 11.82384 ? 475  VAL   B N   1 
ATOM   2999 C CA  . VAL   B 1 120 ? 0.18396   -22.26248 -6.74639  1.000 12.83309 ? 475  VAL   B CA  1 
ATOM   3000 C C   . VAL   B 1 120 ? -1.04738  -21.90080 -7.56782  1.000 12.44477 ? 475  VAL   B C   1 
ATOM   3001 O O   . VAL   B 1 120 ? -1.96329  -21.24068 -7.04569  1.000 12.74387 ? 475  VAL   B O   1 
ATOM   3002 C CB  . VAL   B 1 120 ? 1.26051   -21.15631 -6.79747  1.000 18.87052 ? 475  VAL   B CB  1 
ATOM   3003 C CG1 . VAL   B 1 120 ? 2.38810   -21.49157 -5.83836  1.000 16.43993 ? 475  VAL   B CG1 1 
ATOM   3004 C CG2 . VAL   B 1 120 ? 1.74321   -20.92575 -8.15404  1.000 18.95060 ? 475  VAL   B CG2 1 
ATOM   3005 N N   . HIS   B 1 121 ? -1.13201  -22.40018 -8.81539  1.000 13.06436 ? 476  HIS   B N   1 
ATOM   3006 C CA  . HIS   B 1 121 ? -2.35709  -22.19840 -9.56087  1.000 11.96549 ? 476  HIS   B CA  1 
ATOM   3007 C C   . HIS   B 1 121 ? -3.52312  -22.91431 -8.87475  1.000 13.63389 ? 476  HIS   B C   1 
ATOM   3008 O O   . HIS   B 1 121 ? -4.62640  -22.37036 -8.80665  1.000 13.49741 ? 476  HIS   B O   1 
ATOM   3009 C CB  . HIS   B 1 121 ? -2.15507  -22.68912 -11.01468 1.000 13.90263 ? 476  HIS   B CB  1 
ATOM   3010 C CG  . HIS   B 1 121 ? -3.40578  -22.62145 -11.80031 1.000 15.90117 ? 476  HIS   B CG  1 
ATOM   3011 N ND1 . HIS   B 1 121 ? -3.90710  -23.71322 -12.47028 1.000 18.23730 ? 476  HIS   B ND1 1 
ATOM   3012 C CD2 . HIS   B 1 121 ? -4.30766  -21.63085 -11.94511 1.000 15.82726 ? 476  HIS   B CD2 1 
ATOM   3013 C CE1 . HIS   B 1 121 ? -5.07126  -23.38738 -13.01653 1.000 15.75314 ? 476  HIS   B CE1 1 
ATOM   3014 N NE2 . HIS   B 1 121 ? -5.33072  -22.12806 -12.71875 1.000 17.16937 ? 476  HIS   B NE2 1 
ATOM   3015 N N   . GLN   B 1 122 ? -3.31365  -24.12962 -8.41165  1.000 12.16703 ? 477  GLN   B N   1 
ATOM   3016 C CA  . GLN   B 1 122 ? -4.38204  -24.82738 -7.64641  1.000 12.04206 ? 477  GLN   B CA  1 
ATOM   3017 C C   . GLN   B 1 122 ? -4.81727  -24.00405 -6.44168  1.000 12.65520 ? 477  GLN   B C   1 
ATOM   3018 O O   . GLN   B 1 122 ? -6.00912  -23.83638 -6.18750  1.000 12.13382 ? 477  GLN   B O   1 
ATOM   3019 C CB  . GLN   B 1 122 ? -3.93078  -26.22400 -7.25166  1.000 12.16490 ? 477  GLN   B CB  1 
ATOM   3020 C CG  . GLN   B 1 122 ? -3.84454  -27.17776 -8.45998  1.000 13.58477 ? 477  GLN   B CG  1 
ATOM   3021 C CD  . GLN   B 1 122 ? -3.08886  -28.41597 -8.17455  1.000 15.63925 ? 477  GLN   B CD  1 
ATOM   3022 O OE1 . GLN   B 1 122 ? -2.49033  -28.61223 -7.11158  1.000 17.12934 ? 477  GLN   B OE1 1 
ATOM   3023 N NE2 . GLN   B 1 122 ? -3.08028  -29.31586 -9.15088  1.000 17.71316 ? 477  GLN   B NE2 1 
ATOM   3024 N N   . VAL   B 1 123 ? -3.87704  -23.44550 -5.70346  1.000 12.14883 ? 478  VAL   B N   1 
ATOM   3025 C CA  . VAL   B 1 123 ? -4.26352  -22.58584 -4.57837  1.000 13.58181 ? 478  VAL   B CA  1 
ATOM   3026 C C   . VAL   B 1 123 ? -5.10316  -21.40874 -5.06613  1.000 12.46094 ? 478  VAL   B C   1 
ATOM   3027 O O   . VAL   B 1 123 ? -6.11523  -21.02770 -4.44016  1.000 12.20302 ? 478  VAL   B O   1 
ATOM   3028 C CB  . VAL   B 1 123 ? -3.00119  -22.13211 -3.83071  1.000 10.98878 ? 478  VAL   B CB  1 
ATOM   3029 C CG1 . VAL   B 1 123 ? -3.34185  -21.07293 -2.77722  1.000 12.91432 ? 478  VAL   B CG1 1 
ATOM   3030 C CG2 . VAL   B 1 123 ? -2.31992  -23.32255 -3.15742  1.000 11.72295 ? 478  VAL   B CG2 1 
ATOM   3031 N N   . SER   B 1 124 ? -4.73967  -20.82496 -6.20431  1.000 11.59141 ? 479  SER   B N   1 
ATOM   3032 C CA  . SER   B 1 124 ? -5.50476  -19.69292 -6.73862  1.000 11.23233 ? 479  SER   B CA  1 
ATOM   3033 C C   . SER   B 1 124 ? -6.90913  -20.11488 -7.20373  1.000 12.46626 ? 479  SER   B C   1 
ATOM   3034 O O   . SER   B 1 124 ? -7.83961  -19.30213 -7.09814  1.000 12.86178 ? 479  SER   B O   1 
ATOM   3035 C CB  . SER   B 1 124 ? -4.75574  -18.99295 -7.87807  1.000 13.64048 ? 479  SER   B CB  1 
ATOM   3036 O OG  . SER   B 1 124 ? -4.87195  -19.70136 -9.12032  1.000 13.93036 ? 479  SER   B OG  1 
ATOM   3037 N N   . MET   B 1 125 ? -7.09250  -21.38790 -7.61921  1.000 11.96965 ? 480  MET   B N   1 
ATOM   3038 C CA  . MET   B 1 125 ? -8.45164  -21.86319 -7.91275  1.000 14.14038 ? 480  MET   B CA  1 
ATOM   3039 C C   . MET   B 1 125 ? -9.25771  -22.00534 -6.63062  1.000 14.33964 ? 480  MET   B C   1 
ATOM   3040 O O   . MET   B 1 125 ? -10.41630 -21.59107 -6.57199  1.000 16.74627 ? 480  MET   B O   1 
ATOM   3041 C CB  . MET   B 1 125 ? -8.37862  -23.18707 -8.67219  1.000 14.28735 ? 480  MET   B CB  1 
ATOM   3042 C CG  . MET   B 1 125 ? -7.81547  -22.95058 -10.06383 1.000 15.35653 ? 480  MET   B CG  1 
ATOM   3043 S SD  . MET   B 1 125 ? -7.96851  -24.44959 -11.10809 1.000 21.96421 ? 480  MET   B SD  1 
ATOM   3044 C CE  . MET   B 1 125 ? -6.74230  -25.35964 -10.45829 1.000 18.23567 ? 480  MET   B CE  1 
ATOM   3045 N N   . GLY   B 1 126 ? -8.65542  -22.57040 -5.58636  1.000 13.07197 ? 481  GLY   B N   1 
ATOM   3046 C CA  . GLY   B 1 126 ? -9.36908  -22.63907 -4.31924  1.000 13.88517 ? 481  GLY   B CA  1 
ATOM   3047 C C   . GLY   B 1 126 ? -9.72469  -21.26448 -3.77752  1.000 16.27924 ? 481  GLY   B C   1 
ATOM   3048 O O   . GLY   B 1 126 ? -10.84396 -21.03855 -3.29785  1.000 13.92452 ? 481  GLY   B O   1 
ATOM   3049 N N   . MET   B 1 127 ? -8.81261  -20.29007 -3.92954  1.000 13.42242 ? 482  MET   B N   1 
ATOM   3050 C CA  . MET   B 1 127 ? -9.11438  -18.94064 -3.44899  1.000 12.93120 ? 482  MET   B CA  1 
ATOM   3051 C C   . MET   B 1 127 ? -10.15383 -18.22214 -4.29580  1.000 15.21718 ? 482  MET   B C   1 
ATOM   3052 O O   . MET   B 1 127 ? -10.88116 -17.38482 -3.76016  1.000 14.99633 ? 482  MET   B O   1 
ATOM   3053 C CB  . MET   B 1 127 ? -7.81190  -18.14036 -3.34258  1.000 14.14881 ? 482  MET   B CB  1 
ATOM   3054 C CG  . MET   B 1 127 ? -6.93282  -18.68213 -2.16221  1.000 12.29890 ? 482  MET   B CG  1 
ATOM   3055 S SD  . MET   B 1 127 ? -7.71247  -18.69334 -0.55773  1.000 14.59423 ? 482  MET   B SD  1 
ATOM   3056 C CE  . MET   B 1 127 ? -8.23552  -16.98839 -0.37948  1.000 16.28456 ? 482  MET   B CE  1 
ATOM   3057 N N   . LYS   B 1 128 ? -10.16317 -18.47246 -5.60500  1.000 14.27309 ? 483  LYS   B N   1 
ATOM   3058 C CA  . LYS   B 1 128 ? -11.20665 -17.90625 -6.47622  1.000 12.26762 ? 483  LYS   B CA  1 
ATOM   3059 C C   . LYS   B 1 128 ? -12.57978 -18.37271 -6.00267  1.000 14.81084 ? 483  LYS   B C   1 
ATOM   3060 O O   . LYS   B 1 128 ? -13.51097 -17.56234 -5.88969  1.000 15.06691 ? 483  LYS   B O   1 
ATOM   3061 C CB  . LYS   B 1 128 ? -10.92239 -18.30085 -7.93540  1.000 15.91401 ? 483  LYS   B CB  1 
ATOM   3062 C CG  . LYS   B 1 128 ? -11.97200 -17.73159 -8.90815  1.000 16.21599 ? 483  LYS   B CG  1 
ATOM   3063 C CD  . LYS   B 1 128 ? -11.65467 -18.20143 -10.34112 1.000 19.61509 ? 483  LYS   B CD  1 
ATOM   3064 C CE  . LYS   B 1 128 ? -12.80083 -17.81708 -11.30541 1.000 24.67125 ? 483  LYS   B CE  1 
ATOM   3065 N NZ  . LYS   B 1 128 ? -12.52348 -18.22073 -12.72998 1.000 29.64460 ? 483  LYS   B NZ  1 
ATOM   3066 N N   . TYR   B 1 129 ? -12.68641 -19.65486 -5.65687  1.000 14.04326 ? 484  TYR   B N   1 
ATOM   3067 C CA  . TYR   B 1 129 ? -13.91184 -20.18431 -5.04418  1.000 14.06096 ? 484  TYR   B CA  1 
ATOM   3068 C C   . TYR   B 1 129 ? -14.21824 -19.54706 -3.68678  1.000 15.59873 ? 484  TYR   B C   1 
ATOM   3069 O O   . TYR   B 1 129 ? -15.36727 -19.17506 -3.40905  1.000 17.17779 ? 484  TYR   B O   1 
ATOM   3070 C CB  . TYR   B 1 129 ? -13.79009 -21.69247 -4.91083  1.000 17.80634 ? 484  TYR   B CB  1 
ATOM   3071 C CG  . TYR   B 1 129 ? -14.89586 -22.26743 -4.06588  1.000 16.83937 ? 484  TYR   B CG  1 
ATOM   3072 C CD1 . TYR   B 1 129 ? -16.13078 -22.53493 -4.60694  1.000 20.87819 ? 484  TYR   B CD1 1 
ATOM   3073 C CD2 . TYR   B 1 129 ? -14.67673 -22.55124 -2.73861  1.000 17.34688 ? 484  TYR   B CD2 1 
ATOM   3074 C CE1 . TYR   B 1 129 ? -17.12719 -23.07463 -3.81183  1.000 18.48798 ? 484  TYR   B CE1 1 
ATOM   3075 C CE2 . TYR   B 1 129 ? -15.66593 -23.04137 -1.94506  1.000 19.21511 ? 484  TYR   B CE2 1 
ATOM   3076 C CZ  . TYR   B 1 129 ? -16.88804 -23.30597 -2.49351  1.000 23.45641 ? 484  TYR   B CZ  1 
ATOM   3077 O OH  . TYR   B 1 129 ? -17.88198 -23.82366 -1.69129  1.000 24.35141 ? 484  TYR   B OH  1 
ATOM   3078 N N   . LEU   B 1 130 ? -13.22264 -19.44394 -2.80505  1.000 14.33297 ? 485  LEU   B N   1 
ATOM   3079 C CA  . LEU   B 1 130 ? -13.47810 -18.79564 -1.52269  1.000 16.18790 ? 485  LEU   B CA  1 
ATOM   3080 C C   . LEU   B 1 130 ? -13.98448 -17.37162 -1.71276  1.000 15.67043 ? 485  LEU   B C   1 
ATOM   3081 O O   . LEU   B 1 130 ? -14.94723 -16.95860 -1.03760  1.000 17.06970 ? 485  LEU   B O   1 
ATOM   3082 C CB  . LEU   B 1 130 ? -12.21608 -18.83183 -0.64604  1.000 16.53651 ? 485  LEU   B CB  1 
ATOM   3083 C CG  . LEU   B 1 130 ? -12.42950 -18.69101 0.83011   1.000 19.38354 ? 485  LEU   B CG  1 
ATOM   3084 C CD1 . LEU   B 1 130 ? -13.07693 -20.00481 1.31294   1.000 20.70719 ? 485  LEU   B CD1 1 
ATOM   3085 C CD2 . LEU   B 1 130 ? -11.05757 -18.52055 1.50373   1.000 21.99710 ? 485  LEU   B CD2 1 
ATOM   3086 N N   . GLU   B 1 131 ? -13.37181 -16.61123 -2.64529  1.000 16.03885 ? 486  GLU   B N   1 
ATOM   3087 C CA  . GLU   B 1 131 ? -13.81095 -15.25940 -2.95468  1.000 15.44881 ? 486  GLU   B CA  1 
ATOM   3088 C C   . GLU   B 1 131 ? -15.25459 -15.22916 -3.45034  1.000 16.45145 ? 486  GLU   B C   1 
ATOM   3089 O O   . GLU   B 1 131 ? -16.04265 -14.39450 -2.98996  1.000 16.30219 ? 486  GLU   B O   1 
ATOM   3090 C CB  . GLU   B 1 131 ? -12.87048 -14.66086 -4.00193  1.000 16.98864 ? 486  GLU   B CB  1 
ATOM   3091 C CG  . GLU   B 1 131 ? -13.19949 -13.25753 -4.45134  1.000 17.55647 ? 486  GLU   B CG  1 
ATOM   3092 C CD  . GLU   B 1 131 ? -12.19162 -12.85002 -5.50358  1.000 26.96725 ? 486  GLU   B CD  1 
ATOM   3093 O OE1 . GLU   B 1 131 ? -12.33084 -13.28807 -6.69607  1.000 28.89495 ? 486  GLU   B OE1 1 
ATOM   3094 O OE2 . GLU   B 1 131 ? -11.20553 -12.18283 -5.09972  1.000 26.48129 ? 486  GLU   B OE2 1 
ATOM   3095 N N   . GLU   B 1 132 ? -15.58861 -16.11377 -4.40316  1.000 15.62679 ? 487  GLU   B N   1 
ATOM   3096 C CA  . GLU   B 1 132 ? -16.96084 -16.22294 -4.90732  1.000 18.64519 ? 487  GLU   B CA  1 
ATOM   3097 C C   . GLU   B 1 132 ? -17.92492 -16.53505 -3.78506  1.000 20.68771 ? 487  GLU   B C   1 
ATOM   3098 O O   . GLU   B 1 132 ? -19.09088 -16.11510 -3.83062  1.000 20.35872 ? 487  GLU   B O   1 
ATOM   3099 C CB  . GLU   B 1 132 ? -17.05422 -17.31626 -5.98473  1.000 20.16632 ? 487  GLU   B CB  1 
ATOM   3100 C CG  . GLU   B 1 132 ? -16.39402 -16.94076 -7.33923  1.000 28.17316 ? 487  GLU   B CG  1 
ATOM   3101 C CD  . GLU   B 1 132 ? -16.09450 -18.13861 -8.25612  1.000 33.69793 ? 487  GLU   B CD  1 
ATOM   3102 O OE1 . GLU   B 1 132 ? -16.24017 -19.31669 -7.84403  1.000 33.97328 ? 487  GLU   B OE1 1 
ATOM   3103 O OE2 . GLU   B 1 132 ? -15.68821 -17.91180 -9.41559  1.000 37.83291 ? 487  GLU   B OE2 1 
ATOM   3104 N N   . SER   B 1 133 ? -17.47575 -17.28010 -2.78135  1.000 17.26631 ? 488  SER   B N   1 
ATOM   3105 C CA  . SER   B 1 133 ? -18.30850 -17.66852 -1.64985  1.000 16.21172 ? 488  SER   B CA  1 
ATOM   3106 C C   . SER   B 1 133 ? -18.34714 -16.61479 -0.55676  1.000 18.72977 ? 488  SER   B C   1 
ATOM   3107 O O   . SER   B 1 133 ? -19.01917 -16.82874 0.48064   1.000 20.53653 ? 488  SER   B O   1 
ATOM   3108 C CB  . SER   B 1 133 ? -17.80827 -19.00664 -1.10428  1.000 16.88627 ? 488  SER   B CB  1 
ATOM   3109 O OG  . SER   B 1 133 ? -17.74771 -19.95801 -2.15821  1.000 20.28546 ? 488  SER   B OG  1 
ATOM   3110 N N   . ASN   B 1 134 ? -17.61921 -15.50392 -0.73492  1.000 17.81612 ? 489  ASN   B N   1 
ATOM   3111 C CA  . ASN   B 1 134 ? -17.62375 -14.39440 0.20781   1.000 19.76592 ? 489  ASN   B CA  1 
ATOM   3112 C C   . ASN   B 1 134 ? -17.12119 -14.82016 1.59509   1.000 17.47536 ? 489  ASN   B C   1 
ATOM   3113 O O   . ASN   B 1 134 ? -17.61677 -14.39715 2.64204   1.000 16.30474 ? 489  ASN   B O   1 
ATOM   3114 C CB  . ASN   B 1 134 ? -19.02422 -13.75735 0.23388   1.000 21.06465 ? 489  ASN   B CB  1 
ATOM   3115 C CG  . ASN   B 1 134 ? -19.27205 -12.95080 -1.04204  1.000 23.53598 ? 489  ASN   B CG  1 
ATOM   3116 O OD1 . ASN   B 1 134 ? -18.47548 -12.09875 -1.38604  1.000 32.61769 ? 489  ASN   B OD1 1 
ATOM   3117 N ND2 . ASN   B 1 134 ? -20.32041 -13.27515 -1.75900  1.000 32.71793 ? 489  ASN   B ND2 1 
ATOM   3118 N N   . PHE   B 1 135 ? -16.04698 -15.63009 1.60879   1.000 14.95903 ? 490  PHE   B N   1 
ATOM   3119 C CA  . PHE   B 1 135 ? -15.29541 -15.89538 2.83173   1.000 15.18897 ? 490  PHE   B CA  1 
ATOM   3120 C C   . PHE   B 1 135 ? -13.92274 -15.27855 2.67904   1.000 13.92352 ? 490  PHE   B C   1 
ATOM   3121 O O   . PHE   B 1 135 ? -13.38039 -15.27279 1.57146   1.000 16.34179 ? 490  PHE   B O   1 
ATOM   3122 C CB  . PHE   B 1 135 ? -15.08747 -17.39038 3.11001   1.000 14.23990 ? 490  PHE   B CB  1 
ATOM   3123 C CG  . PHE   B 1 135 ? -16.32011 -18.10369 3.60636   1.000 13.97605 ? 490  PHE   B CG  1 
ATOM   3124 C CD1 . PHE   B 1 135 ? -17.24587 -18.59671 2.69196   1.000 21.57943 ? 490  PHE   B CD1 1 
ATOM   3125 C CD2 . PHE   B 1 135 ? -16.52184 -18.27640 4.95387   1.000 17.82579 ? 490  PHE   B CD2 1 
ATOM   3126 C CE1 . PHE   B 1 135 ? -18.38797 -19.23644 3.11853   1.000 27.88715 ? 490  PHE   B CE1 1 
ATOM   3127 C CE2 . PHE   B 1 135 ? -17.68212 -18.93391 5.39276   1.000 22.11252 ? 490  PHE   B CE2 1 
ATOM   3128 C CZ  . PHE   B 1 135 ? -18.58679 -19.40093 4.46069   1.000 19.65653 ? 490  PHE   B CZ  1 
ATOM   3129 N N   . VAL   B 1 136 ? -13.37524 -14.75619 3.75697   1.000 11.96546 ? 491  VAL   B N   1 
ATOM   3130 C CA  . VAL   B 1 136 ? -11.97258 -14.33533 3.77944   1.000 14.93345 ? 491  VAL   B CA  1 
ATOM   3131 C C   . VAL   B 1 136 ? -11.19002 -15.33853 4.61184   1.000 13.87496 ? 491  VAL   B C   1 
ATOM   3132 O O   . VAL   B 1 136 ? -11.66936 -15.80471 5.65518   1.000 14.07835 ? 491  VAL   B O   1 
ATOM   3133 C CB  . VAL   B 1 136 ? -11.81049 -12.90085 4.31271   1.000 15.46384 ? 491  VAL   B CB  1 
ATOM   3134 C CG1 . VAL   B 1 136 ? -12.51443 -11.92094 3.36429   1.000 19.71431 ? 491  VAL   B CG1 1 
ATOM   3135 C CG2 . VAL   B 1 136 ? -12.39316 -12.69359 5.67509   1.000 15.64119 ? 491  VAL   B CG2 1 
ATOM   3136 N N   . HIS   B 1 137 ? -10.03197 -15.77045 4.09466   1.000 12.61883 ? 492  HIS   B N   1 
ATOM   3137 C CA  . HIS   B 1 137 ? -9.27418  -16.81513 4.76789   1.000 11.14119 ? 492  HIS   B CA  1 
ATOM   3138 C C   . HIS   B 1 137 ? -8.53760  -16.25422 5.97987   1.000 12.80182 ? 492  HIS   B C   1 
ATOM   3139 O O   . HIS   B 1 137 ? -8.57936  -16.83888 7.06844   1.000 12.28229 ? 492  HIS   B O   1 
ATOM   3140 C CB  . HIS   B 1 137 ? -8.30002  -17.45966 3.75691   1.000 12.67656 ? 492  HIS   B CB  1 
ATOM   3141 C CG  . HIS   B 1 137 ? -7.57741  -18.63992 4.31996   1.000 11.95554 ? 492  HIS   B CG  1 
ATOM   3142 N ND1 . HIS   B 1 137 ? -6.49679  -18.51450 5.17430   1.000 12.31193 ? 492  HIS   B ND1 1 
ATOM   3143 C CD2 . HIS   B 1 137 ? -7.82123  -19.97082 4.19383   1.000 15.25773 ? 492  HIS   B CD2 1 
ATOM   3144 C CE1 . HIS   B 1 137 ? -6.09607  -19.72255 5.52924   1.000 12.60263 ? 492  HIS   B CE1 1 
ATOM   3145 N NE2 . HIS   B 1 137 ? -6.87209  -20.62162 4.94254   1.000 13.75013 ? 492  HIS   B NE2 1 
ATOM   3146 N N   . ARG   B 1 138 ? -7.78621  -15.16055 5.79641   1.000 10.86012 ? 493  ARG   B N   1 
ATOM   3147 C CA  . ARG   B 1 138 ? -7.05469  -14.43201 6.83567   1.000 12.32625 ? 493  ARG   B CA  1 
ATOM   3148 C C   . ARG   B 1 138 ? -5.83557  -15.16207 7.38646   1.000 11.85951 ? 493  ARG   B C   1 
ATOM   3149 O O   . ARG   B 1 138 ? -5.22043  -14.70491 8.35791   1.000 14.20644 ? 493  ARG   B O   1 
ATOM   3150 C CB  . ARG   B 1 138 ? -7.96717  -14.00898 7.99024   1.000 15.69346 ? 493  ARG   B CB  1 
ATOM   3151 C CG  . ARG   B 1 138 ? -8.98876  -13.05900 7.48420   1.000 14.34691 ? 493  ARG   B CG  1 
ATOM   3152 C CD  . ARG   B 1 138 ? -9.92959  -12.52973 8.62157   1.000 15.69538 ? 493  ARG   B CD  1 
ATOM   3153 N NE  . ARG   B 1 138 ? -9.13297  -11.70172 9.50973   1.000 19.67996 ? 493  ARG   B NE  1 
ATOM   3154 C CZ  . ARG   B 1 138 ? -9.00053  -11.88571 10.82150  1.000 22.46317 ? 493  ARG   B CZ  1 
ATOM   3155 N NH1 . ARG   B 1 138 ? -9.46453  -12.96360 11.43124  1.000 21.95473 ? 493  ARG   B NH1 1 
ATOM   3156 N NH2 . ARG   B 1 138 ? -8.39388  -10.95230 11.55351  1.000 22.70326 ? 493  ARG   B NH2 1 
ATOM   3157 N N   . ASP   B 1 139 ? -5.40258  -16.26550 6.77677   1.000 11.69658 ? 494  ASP   B N   1 
ATOM   3158 C CA  . ASP   B 1 139 ? -4.13230  -16.86039 7.19984   1.000 14.41291 ? 494  ASP   B CA  1 
ATOM   3159 C C   . ASP   B 1 139 ? -3.52627  -17.61200 6.01395   1.000 12.53856 ? 494  ASP   B C   1 
ATOM   3160 O O   . ASP   B 1 139 ? -3.11147  -18.75658 6.13594   1.000 12.85515 ? 494  ASP   B O   1 
ATOM   3161 C CB  . ASP   B 1 139 ? -4.35081  -17.81065 8.40035   1.000 14.75933 ? 494  ASP   B CB  1 
ATOM   3162 C CG  . ASP   B 1 139 ? -3.07652  -18.08932 9.15565   1.000 19.20530 ? 494  ASP   B CG  1 
ATOM   3163 O OD1 . ASP   B 1 139 ? -2.04102  -17.50157 8.81025   1.000 21.92163 ? 494  ASP   B OD1 1 
ATOM   3164 O OD2 . ASP   B 1 139 ? -3.14986  -18.94901 10.09246  1.000 21.76746 ? 494  ASP   B OD2 1 
ATOM   3165 N N   . LEU   B 1 140 ? -3.52995  -17.01276 4.82668   1.000 12.04064 ? 495  LEU   B N   1 
ATOM   3166 C CA  . LEU   B 1 140 ? -3.12176  -17.72539 3.60379   1.000 11.42245 ? 495  LEU   B CA  1 
ATOM   3167 C C   . LEU   B 1 140 ? -1.60243  -17.66758 3.49028   1.000 13.46388 ? 495  LEU   B C   1 
ATOM   3168 O O   . LEU   B 1 140 ? -1.03381  -16.67139 3.06784   1.000 19.37129 ? 495  LEU   B O   1 
ATOM   3169 C CB  . LEU   B 1 140 ? -3.78728  -17.09209 2.39022   1.000 13.43398 ? 495  LEU   B CB  1 
ATOM   3170 C CG  . LEU   B 1 140 ? -3.49138  -17.79260 1.07160   1.000 13.94544 ? 495  LEU   B CG  1 
ATOM   3171 C CD1 . LEU   B 1 140 ? -3.94982  -19.26883 1.09935   1.000 14.38403 ? 495  LEU   B CD1 1 
ATOM   3172 C CD2 . LEU   B 1 140 ? -4.25258  -17.01178 -0.00490  1.000 16.09883 ? 495  LEU   B CD2 1 
ATOM   3173 N N   . ALA   B 1 141 ? -0.96214  -18.77538 3.80556   1.000 12.30991 ? 496  ALA   B N   1 
ATOM   3174 C CA  . ALA   B 1 141 ? 0.49297   -18.87543 3.88980   1.000 10.55255 ? 496  ALA   B CA  1 
ATOM   3175 C C   . ALA   B 1 141 ? 0.84317   -20.28526 3.46244   1.000 12.62514 ? 496  ALA   B C   1 
ATOM   3176 O O   . ALA   B 1 141 ? -0.01252  -21.16572 3.44615   1.000 13.90044 ? 496  ALA   B O   1 
ATOM   3177 C CB  . ALA   B 1 141 ? 0.95722   -18.61159 5.31791   1.000 12.38828 ? 496  ALA   B CB  1 
ATOM   3178 N N   . ALA   B 1 142 ? 2.08231   -20.48413 3.02526   1.000 12.41638 ? 497  ALA   B N   1 
ATOM   3179 C CA  . ALA   B 1 142 ? 2.43893   -21.79734 2.50995   1.000 11.67860 ? 497  ALA   B CA  1 
ATOM   3180 C C   . ALA   B 1 142 ? 2.32378   -22.91055 3.54003   1.000 11.82269 ? 497  ALA   B C   1 
ATOM   3181 O O   . ALA   B 1 142 ? 2.03963   -24.05925 3.13975   1.000 12.65211 ? 497  ALA   B O   1 
ATOM   3182 C CB  . ALA   B 1 142 ? 3.84869   -21.75898 1.89828   1.000 13.13813 ? 497  ALA   B CB  1 
ATOM   3183 N N   . ARG   B 1 143 ? 2.45213   -22.61934 4.84175   1.000 11.49347 ? 498  ARG   B N   1 
ATOM   3184 C CA  . ARG   B 1 143 ? 2.24295   -23.67910 5.83151   1.000 14.30216 ? 498  ARG   B CA  1 
ATOM   3185 C C   . ARG   B 1 143 ? 0.79524   -24.14962 5.88034   1.000 12.99222 ? 498  ARG   B C   1 
ATOM   3186 O O   . ARG   B 1 143 ? 0.54228   -25.22577 6.41896   1.000 13.80619 ? 498  ARG   B O   1 
ATOM   3187 C CB  . ARG   B 1 143 ? 2.66418   -23.18782 7.23295   1.000 15.86314 ? 498  ARG   B CB  1 
ATOM   3188 C CG  . ARG   B 1 143 ? 1.80874   -22.02921 7.70461   1.000 15.38637 ? 498  ARG   B CG  1 
ATOM   3189 C CD  . ARG   B 1 143 ? 2.17405   -21.44296 9.13753   1.000 21.12540 ? 498  ARG   B CD  1 
ATOM   3190 N NE  . ARG   B 1 143 ? 1.37411   -20.24926 9.42170   1.000 23.10756 ? 498  ARG   B NE  1 
ATOM   3191 C CZ  . ARG   B 1 143 ? 1.66825   -19.03110 8.96056   1.000 27.93973 ? 498  ARG   B CZ  1 
ATOM   3192 N NH1 . ARG   B 1 143 ? 2.78146   -18.79367 8.27264   1.000 25.83175 ? 498  ARG   B NH1 1 
ATOM   3193 N NH2 . ARG   B 1 143 ? 0.82943   -18.02199 9.19167   1.000 30.30863 ? 498  ARG   B NH2 1 
ATOM   3194 N N   . ASN   B 1 144 ? -0.13735  -23.38117 5.30803   1.000 11.20404 ? 499  ASN   B N   1 
ATOM   3195 C CA  . ASN   B 1 144 ? -1.57317  -23.67221 5.33776   1.000 12.87489 ? 499  ASN   B CA  1 
ATOM   3196 C C   . ASN   B 1 144 ? -2.04727  -24.19083 3.99657   1.000 15.58295 ? 499  ASN   B C   1 
ATOM   3197 O O   . ASN   B 1 144 ? -3.24218  -24.15549 3.68804   1.000 18.74334 ? 499  ASN   B O   1 
ATOM   3198 C CB  . ASN   B 1 144 ? -2.29668  -22.43039 5.79927   1.000 12.12137 ? 499  ASN   B CB  1 
ATOM   3199 C CG  . ASN   B 1 144 ? -2.04742  -22.13714 7.28062   1.000 14.23056 ? 499  ASN   B CG  1 
ATOM   3200 O OD1 . ASN   B 1 144 ? -1.68175  -23.01933 8.08651   1.000 13.64089 ? 499  ASN   B OD1 1 
ATOM   3201 N ND2 . ASN   B 1 144 ? -2.19957  -20.88909 7.64070   1.000 15.24840 ? 499  ASN   B ND2 1 
ATOM   3202 N N   . VAL   B 1 145 ? -1.11892  -24.59520 3.15923   1.000 12.41348 ? 500  VAL   B N   1 
ATOM   3203 C CA  . VAL   B 1 145 ? -1.41397  -25.36145 1.95673   1.000 12.23901 ? 500  VAL   B CA  1 
ATOM   3204 C C   . VAL   B 1 145 ? -0.91600  -26.76782 2.21136   1.000 12.25690 ? 500  VAL   B C   1 
ATOM   3205 O O   . VAL   B 1 145 ? 0.23499   -26.94461 2.63276   1.000 13.47027 ? 500  VAL   B O   1 
ATOM   3206 C CB  . VAL   B 1 145 ? -0.70588  -24.76021 0.73026   1.000 12.23524 ? 500  VAL   B CB  1 
ATOM   3207 C CG1 . VAL   B 1 145 ? -1.02417  -25.61862 -0.56460  1.000 13.55642 ? 500  VAL   B CG1 1 
ATOM   3208 C CG2 . VAL   B 1 145 ? -1.20531  -23.32904 0.54017   1.000 15.35164 ? 500  VAL   B CG2 1 
ATOM   3209 N N   . LEU   B 1 146 ? -1.78559  -27.75930 2.04639   1.000 11.58912 ? 501  LEU   B N   1 
ATOM   3210 C CA  . LEU   B 1 146 ? -1.42376  -29.14669 2.32570   1.000 11.43925 ? 501  LEU   B CA  1 
ATOM   3211 C C   . LEU   B 1 146 ? -1.39153  -29.94079 1.02314   1.000 11.78333 ? 501  LEU   B C   1 
ATOM   3212 O O   . LEU   B 1 146 ? -2.19196  -29.69332 0.13334   1.000 15.99468 ? 501  LEU   B O   1 
ATOM   3213 C CB  . LEU   B 1 146 ? -2.43840  -29.80057 3.26038   1.000 15.11822 ? 501  LEU   B CB  1 
ATOM   3214 C CG  . LEU   B 1 146 ? -2.58229  -29.03060 4.56933   1.000 17.69409 ? 501  LEU   B CG  1 
ATOM   3215 C CD1 . LEU   B 1 146 ? -3.55918  -29.77470 5.42413   1.000 19.65461 ? 501  LEU   B CD1 1 
ATOM   3216 C CD2 . LEU   B 1 146 ? -1.25362  -28.75787 5.31003   1.000 28.06201 ? 501  LEU   B CD2 1 
ATOM   3217 N N   . LEU   B 1 147 ? -0.45479  -30.86599 0.88213   1.000 13.34448 ? 502  LEU   B N   1 
ATOM   3218 C CA  . LEU   B 1 147 ? -0.35856  -31.61869 -0.36773  1.000 12.01868 ? 502  LEU   B CA  1 
ATOM   3219 C C   . LEU   B 1 147 ? -1.02164  -32.99486 -0.25745  1.000 13.66141 ? 502  LEU   B C   1 
ATOM   3220 O O   . LEU   B 1 147 ? -0.76240  -33.75590 0.69752   1.000 12.99645 ? 502  LEU   B O   1 
ATOM   3221 C CB  . LEU   B 1 147 ? 1.11501   -31.77491 -0.76094  1.000 14.37631 ? 502  LEU   B CB  1 
ATOM   3222 C CG  . LEU   B 1 147 ? 1.82259   -30.48805 -1.13860  1.000 14.43002 ? 502  LEU   B CG  1 
ATOM   3223 C CD1 . LEU   B 1 147 ? 3.29585   -30.79823 -1.48327  1.000 17.93705 ? 502  LEU   B CD1 1 
ATOM   3224 C CD2 . LEU   B 1 147 ? 1.13386   -29.87468 -2.33017  1.000 17.37028 ? 502  LEU   B CD2 1 
ATOM   3225 N N   . VAL   B 1 148 ? -1.91318  -33.27168 -1.20868  1.000 12.26990 ? 503  VAL   B N   1 
ATOM   3226 C CA  . VAL   B 1 148 ? -2.50539  -34.60086 -1.36161  1.000 12.91243 ? 503  VAL   B CA  1 
ATOM   3227 C C   . VAL   B 1 148 ? -1.53498  -35.49878 -2.11431  1.000 15.14761 ? 503  VAL   B C   1 
ATOM   3228 O O   . VAL   B 1 148 ? -1.31919  -36.66344 -1.75673  1.000 15.63950 ? 503  VAL   B O   1 
ATOM   3229 C CB  . VAL   B 1 148 ? -3.82665  -34.44857 -2.10647  1.000 13.55087 ? 503  VAL   B CB  1 
ATOM   3230 C CG1 . VAL   B 1 148 ? -4.47296  -35.81442 -2.39930  1.000 16.69562 ? 503  VAL   B CG1 1 
ATOM   3231 C CG2 . VAL   B 1 148 ? -4.80540  -33.56329 -1.30839  1.000 18.97539 ? 503  VAL   B CG2 1 
ATOM   3232 N N   . THR   B 1 149 ? -0.96950  -34.94890 -3.19063  1.000 15.29361 ? 504  THR   B N   1 
ATOM   3233 C CA  . THR   B 1 149 ? 0.13831   -35.56728 -3.90616  1.000 13.75202 ? 504  THR   B CA  1 
ATOM   3234 C C   . THR   B 1 149 ? 1.11722   -34.44959 -4.26214  1.000 13.28893 ? 504  THR   B C   1 
ATOM   3235 O O   . THR   B 1 149 ? 0.82903   -33.26236 -4.05540  1.000 14.37214 ? 504  THR   B O   1 
ATOM   3236 C CB  . THR   B 1 149 ? -0.28265  -36.28650 -5.19214  1.000 17.10857 ? 504  THR   B CB  1 
ATOM   3237 O OG1 . THR   B 1 149 ? -0.59974  -35.32019 -6.19975  1.000 15.91524 ? 504  THR   B OG1 1 
ATOM   3238 C CG2 . THR   B 1 149 ? -1.53256  -37.17966 -4.96128  1.000 17.92818 ? 504  THR   B CG2 1 
ATOM   3239 N N   . GLN   B 1 150 ? 2.26186   -34.80415 -4.86792  1.000 15.23460 ? 505  GLN   B N   1 
ATOM   3240 C CA  . GLN   B 1 150 ? 3.18354   -33.76898 -5.32745  1.000 16.25838 ? 505  GLN   B CA  1 
ATOM   3241 C C   . GLN   B 1 150 ? 2.55591   -32.84054 -6.36870  1.000 16.18201 ? 505  GLN   B C   1 
ATOM   3242 O O   . GLN   B 1 150 ? 3.10041   -31.74574 -6.61116  1.000 16.30897 ? 505  GLN   B O   1 
ATOM   3243 C CB  . GLN   B 1 150 ? 4.43334   -34.44468 -5.91888  1.000 21.76307 ? 505  GLN   B CB  1 
ATOM   3244 C CG  . GLN   B 1 150 ? 5.53017   -33.52352 -6.28445  1.000 22.34353 ? 505  GLN   B CG  1 
ATOM   3245 C CD  . GLN   B 1 150 ? 6.67401   -34.25269 -6.90474  1.000 27.00384 ? 505  GLN   B CD  1 
ATOM   3246 O OE1 . GLN   B 1 150 ? 6.86744   -35.45823 -6.68411  1.000 28.39941 ? 505  GLN   B OE1 1 
ATOM   3247 N NE2 . GLN   B 1 150 ? 7.43740   -33.54664 -7.69649  1.000 24.71696 ? 505  GLN   B NE2 1 
ATOM   3248 N N   . HIS   B 1 151 ? 1.39344   -33.19736 -6.92564  1.000 16.21656 ? 506  HIS   B N   1 
ATOM   3249 C CA  . HIS   B 1 151 ? 0.70786   -32.44809 -7.97859  1.000 15.04311 ? 506  HIS   B CA  1 
ATOM   3250 C C   . HIS   B 1 151 ? -0.69733  -32.04933 -7.58509  1.000 15.07314 ? 506  HIS   B C   1 
ATOM   3251 O O   . HIS   B 1 151 ? -1.50403  -31.72619 -8.45105  1.000 15.35844 ? 506  HIS   B O   1 
ATOM   3252 C CB  . HIS   B 1 151 ? 0.66746   -33.25004 -9.29052  1.000 15.75730 ? 506  HIS   B CB  1 
ATOM   3253 C CG  . HIS   B 1 151 ? 2.03516   -33.57932 -9.80313  1.000 17.83132 ? 506  HIS   B CG  1 
ATOM   3254 N ND1 . HIS   B 1 151 ? 2.82575   -32.64590 -10.45275 1.000 20.67129 ? 506  HIS   B ND1 1 
ATOM   3255 C CD2 . HIS   B 1 151 ? 2.80151   -34.68886 -9.64511  1.000 16.74377 ? 506  HIS   B CD2 1 
ATOM   3256 C CE1 . HIS   B 1 151 ? 3.99746   -33.19813 -10.72845 1.000 18.81077 ? 506  HIS   B CE1 1 
ATOM   3257 N NE2 . HIS   B 1 151 ? 4.02342   -34.42516 -10.22298 1.000 21.54284 ? 506  HIS   B NE2 1 
ATOM   3258 N N   . TYR   B 1 152 ? -0.99733  -32.00631 -6.27779  1.000 13.90370 ? 507  TYR   B N   1 
ATOM   3259 C CA  . TYR   B 1 152 ? -2.36480  -31.66465 -5.87043  1.000 14.34714 ? 507  TYR   B CA  1 
ATOM   3260 C C   . TYR   B 1 152 ? -2.32294  -31.01639 -4.48494  1.000 13.05152 ? 507  TYR   B C   1 
ATOM   3261 O O   . TYR   B 1 152 ? -2.07748  -31.70635 -3.47416  1.000 13.88460 ? 507  TYR   B O   1 
ATOM   3262 C CB  . TYR   B 1 152 ? -3.24178  -32.92640 -5.90576  1.000 14.57758 ? 507  TYR   B CB  1 
ATOM   3263 C CG  . TYR   B 1 152 ? -4.69992  -32.76529 -5.56046  1.000 15.96364 ? 507  TYR   B CG  1 
ATOM   3264 C CD1 . TYR   B 1 152 ? -5.29262  -31.52571 -5.41052  1.000 13.20427 ? 507  TYR   B CD1 1 
ATOM   3265 C CD2 . TYR   B 1 152 ? -5.49805  -33.88618 -5.45291  1.000 15.90056 ? 507  TYR   B CD2 1 
ATOM   3266 C CE1 . TYR   B 1 152 ? -6.65619  -31.39407 -5.09560  1.000 16.61531 ? 507  TYR   B CE1 1 
ATOM   3267 C CE2 . TYR   B 1 152 ? -6.84398  -33.78244 -5.12416  1.000 16.29876 ? 507  TYR   B CE2 1 
ATOM   3268 C CZ  . TYR   B 1 152 ? -7.41678  -32.55447 -4.93326  1.000 15.59417 ? 507  TYR   B CZ  1 
ATOM   3269 O OH  . TYR   B 1 152 ? -8.73658  -32.45617 -4.64120  1.000 19.11965 ? 507  TYR   B OH  1 
ATOM   3270 N N   . ALA   B 1 153 ? -2.55683  -29.69933 -4.46127  1.000 13.66270 ? 508  ALA   B N   1 
ATOM   3271 C CA  . ALA   B 1 153 ? -2.56498  -28.86038 -3.26253  1.000 14.50984 ? 508  ALA   B CA  1 
ATOM   3272 C C   . ALA   B 1 153 ? -3.99319  -28.51721 -2.85326  1.000 13.39637 ? 508  ALA   B C   1 
ATOM   3273 O O   . ALA   B 1 153 ? -4.87738  -28.37160 -3.69576  1.000 13.11012 ? 508  ALA   B O   1 
ATOM   3274 C CB  . ALA   B 1 153 ? -1.85006  -27.54478 -3.53514  1.000 12.75526 ? 508  ALA   B CB  1 
ATOM   3275 N N   . LYS   B 1 154 ? -4.20744  -28.43315 -1.51922  1.000 12.85214 ? 509  LYS   B N   1 
ATOM   3276 C CA  . LYS   B 1 154 ? -5.45724  -28.01328 -0.88943  1.000 12.02183 ? 509  LYS   B CA  1 
ATOM   3277 C C   . LYS   B 1 154 ? -5.15959  -26.93786 0.14677   1.000 14.19038 ? 509  LYS   B C   1 
ATOM   3278 O O   . LYS   B 1 154 ? -4.17521  -27.02402 0.86194   1.000 15.81778 ? 509  LYS   B O   1 
ATOM   3279 C CB  . LYS   B 1 154 ? -6.11566  -29.19717 -0.16965  1.000 12.67811 ? 509  LYS   B CB  1 
ATOM   3280 C CG  . LYS   B 1 154 ? -6.79689  -30.14260 -1.16146  1.000 13.52807 ? 509  LYS   B CG  1 
ATOM   3281 C CD  . LYS   B 1 154 ? -7.40224  -31.32390 -0.39674  1.000 19.32522 ? 509  LYS   B CD  1 
ATOM   3282 C CE  . LYS   B 1 154 ? -8.24645  -32.17845 -1.35583  1.000 17.32753 ? 509  LYS   B CE  1 
ATOM   3283 N NZ  . LYS   B 1 154 ? -9.65966  -31.60036 -1.35504  1.000 20.92072 ? 509  LYS   B NZ  1 
ATOM   3284 N N   . ILE   B 1 155 ? -6.04350  -25.97996 0.29017   1.000 12.47810 ? 510  ILE   B N   1 
ATOM   3285 C CA  . ILE   B 1 155 ? -5.94603  -24.95882 1.33790   1.000 12.67461 ? 510  ILE   B CA  1 
ATOM   3286 C C   . ILE   B 1 155 ? -6.56377  -25.48557 2.62535   1.000 11.66537 ? 510  ILE   B C   1 
ATOM   3287 O O   . ILE   B 1 155 ? -7.66287  -26.05435 2.60592   1.000 13.06388 ? 510  ILE   B O   1 
ATOM   3288 C CB  . ILE   B 1 155 ? -6.67203  -23.70417 0.85633   1.000 11.14112 ? 510  ILE   B CB  1 
ATOM   3289 C CG1 . ILE   B 1 155 ? -6.08345  -23.16721 -0.48344  1.000 13.80763 ? 510  ILE   B CG1 1 
ATOM   3290 C CG2 . ILE   B 1 155 ? -6.68741  -22.67390 2.02789   1.000 13.04848 ? 510  ILE   B CG2 1 
ATOM   3291 C CD1 . ILE   B 1 155 ? -7.07742  -22.29471 -1.23926  1.000 13.42797 ? 510  ILE   B CD1 1 
ATOM   3292 N N   . SER   B 1 156 ? -5.86403  -25.24556 3.73389   1.000 11.63709 ? 511  SER   B N   1 
ATOM   3293 C CA  . SER   B 1 156 ? -6.29952  -25.68589 5.02976   1.000 12.70773 ? 511  SER   B CA  1 
ATOM   3294 C C   . SER   B 1 156 ? -6.41769  -24.46651 5.93590   1.000 14.07013 ? 511  SER   B C   1 
ATOM   3295 O O   . SER   B 1 156 ? -6.16323  -23.33340 5.54069   1.000 13.37085 ? 511  SER   B O   1 
ATOM   3296 C CB  . SER   B 1 156 ? -5.27879  -26.68049 5.59849   1.000 15.93499 ? 511  SER   B CB  1 
ATOM   3297 O OG  . SER   B 1 156 ? -4.02820  -25.99959 5.81347   1.000 21.78786 ? 511  SER   B OG  1 
ATOM   3298 N N   . ASP   B 1 157 ? -6.69193  -24.75683 7.21106   1.000 12.46555 ? 512  ASP   B N   1 
ATOM   3299 C CA  . ASP   B 1 157 ? -6.45861  -23.83750 8.32894   1.000 12.42788 ? 512  ASP   B CA  1 
ATOM   3300 C C   . ASP   B 1 157 ? -7.36003  -22.61102 8.26352   1.000 11.44546 ? 512  ASP   B C   1 
ATOM   3301 O O   . ASP   B 1 157 ? -6.91236  -21.47133 8.05388   1.000 14.45357 ? 512  ASP   B O   1 
ATOM   3302 C CB  . ASP   B 1 157 ? -4.95748  -23.47015 8.42261   1.000 12.26145 ? 512  ASP   B CB  1 
ATOM   3303 C CG  . ASP   B 1 157 ? -4.18229  -24.55375 9.16299   1.000 16.98067 ? 512  ASP   B CG  1 
ATOM   3304 O OD1 . ASP   B 1 157 ? -3.78306  -25.55044 8.55571   1.000 16.94931 ? 512  ASP   B OD1 1 
ATOM   3305 O OD2 . ASP   B 1 157 ? -4.10389  -24.45860 10.40639  1.000 23.37958 ? 512  ASP   B OD2 1 
ATOM   3306 N N   . PHE   B 1 158 ? -8.63883  -22.86540 8.57661   1.000 12.78142 ? 513  PHE   B N   1 
ATOM   3307 C CA  . PHE   B 1 158 ? -9.69231  -21.87507 8.51948   1.000 12.25034 ? 513  PHE   B CA  1 
ATOM   3308 C C   . PHE   B 1 158 ? -10.00402 -21.28370 9.89972   1.000 12.54269 ? 513  PHE   B C   1 
ATOM   3309 O O   . PHE   B 1 158 ? -11.01968 -20.62373 10.04915  1.000 14.94422 ? 513  PHE   B O   1 
ATOM   3310 C CB  . PHE   B 1 158 ? -10.91609 -22.50578 7.85303   1.000 12.88881 ? 513  PHE   B CB  1 
ATOM   3311 C CG  . PHE   B 1 158 ? -10.69893 -22.75260 6.39161   1.000 13.81219 ? 513  PHE   B CG  1 
ATOM   3312 C CD1 . PHE   B 1 158 ? -11.03225 -21.76396 5.46329   1.000 15.45598 ? 513  PHE   B CD1 1 
ATOM   3313 C CD2 . PHE   B 1 158 ? -10.17873 -23.95527 5.94010   1.000 14.08859 ? 513  PHE   B CD2 1 
ATOM   3314 C CE1 . PHE   B 1 158 ? -10.77885 -21.98643 4.10768   1.000 17.47531 ? 513  PHE   B CE1 1 
ATOM   3315 C CE2 . PHE   B 1 158 ? -9.93953  -24.14509 4.56138   1.000 15.99106 ? 513  PHE   B CE2 1 
ATOM   3316 C CZ  . PHE   B 1 158 ? -10.23607 -23.15656 3.67753   1.000 15.18947 ? 513  PHE   B CZ  1 
ATOM   3317 N N   . GLY   B 1 159 ? -9.05379  -21.37039 10.82981  1.000 14.80442 ? 514  GLY   B N   1 
ATOM   3318 C CA  . GLY   B 1 159 ? -9.25680  -20.86079 12.19075  1.000 14.34666 ? 514  GLY   B CA  1 
ATOM   3319 C C   . GLY   B 1 159 ? -9.42408  -19.35245 12.30686  1.000 17.36765 ? 514  GLY   B C   1 
ATOM   3320 O O   . GLY   B 1 159 ? -10.07407 -18.87821 13.25684  1.000 18.90213 ? 514  GLY   B O   1 
ATOM   3321 N N   . LEU   B 1 160 ? -8.87088  -18.57855 11.38133  1.000 14.57065 ? 515  LEU   B N   1 
ATOM   3322 C CA  . LEU   B 1 160 ? -9.09795  -17.12111 11.36051  1.000 13.27974 ? 515  LEU   B CA  1 
ATOM   3323 C C   . LEU   B 1 160 ? -10.11649 -16.66246 10.31383  1.000 12.64101 ? 515  LEU   B C   1 
ATOM   3324 O O   . LEU   B 1 160 ? -10.38631 -15.45055 10.19685  1.000 13.66127 ? 515  LEU   B O   1 
ATOM   3325 C CB  . LEU   B 1 160 ? -7.79056  -16.34855 11.09693  1.000 14.66345 ? 515  LEU   B CB  1 
ATOM   3326 C CG  . LEU   B 1 160 ? -6.68404  -16.56068 12.12552  1.000 19.63798 ? 515  LEU   B CG  1 
ATOM   3327 C CD1 . LEU   B 1 160 ? -5.41331  -15.74935 11.83593  1.000 22.43258 ? 515  LEU   B CD1 1 
ATOM   3328 C CD2 . LEU   B 1 160 ? -7.18476  -16.30073 13.55184  1.000 28.27087 ? 515  LEU   B CD2 1 
ATOM   3329 N N   . SER   B 1 161 ? -10.70395 -17.59774 9.58166   1.000 12.80105 ? 516  SER   B N   1 
ATOM   3330 C CA  . SER   B 1 161 ? -11.54858 -17.25943 8.45572   1.000 11.57289 ? 516  SER   B CA  1 
ATOM   3331 C C   . SER   B 1 161 ? -12.87464 -16.68415 8.92875   1.000 15.81460 ? 516  SER   B C   1 
ATOM   3332 O O   . SER   B 1 161 ? -13.38413 -17.01729 10.01266  1.000 16.64811 ? 516  SER   B O   1 
ATOM   3333 C CB  . SER   B 1 161 ? -11.79164 -18.48798 7.60357   1.000 15.52721 ? 516  SER   B CB  1 
ATOM   3334 O OG  . SER   B 1 161 ? -10.54626 -19.01564 7.12775   0.586 12.93210 ? 516  SER   B OG  1 
ATOM   3335 N N   . LYS   B 1 162 ? -13.43137 -15.81312 8.09954   1.000 15.04385 ? 517  LYS   B N   1 
ATOM   3336 C CA  . LYS   B 1 162 ? -14.70158 -15.16032 8.41457   1.000 14.39114 ? 517  LYS   B CA  1 
ATOM   3337 C C   . LYS   B 1 162 ? -15.63989 -15.23708 7.22267   1.000 15.12307 ? 517  LYS   B C   1 
ATOM   3338 O O   . LYS   B 1 162 ? -15.23116 -15.08276 6.06671   1.000 14.88383 ? 517  LYS   B O   1 
ATOM   3339 C CB  . LYS   B 1 162 ? -14.48160 -13.71662 8.80281   1.000 14.72765 ? 517  LYS   B CB  1 
ATOM   3340 C CG  . LYS   B 1 162 ? -13.58868 -13.52030 9.98724   1.000 16.15802 ? 517  LYS   B CG  1 
ATOM   3341 C CD  . LYS   B 1 162 ? -14.31356 -13.98571 11.23355  1.000 20.57834 ? 517  LYS   B CD  1 
ATOM   3342 C CE  . LYS   B 1 162 ? -13.38194 -13.85313 12.39965  1.000 24.99494 ? 517  LYS   B CE  1 
ATOM   3343 N NZ  . LYS   B 1 162 ? -14.20780 -13.90050 13.64522  1.000 29.21869 ? 517  LYS   B NZ  1 
ATOM   3344 N N   . ALA   B 1 163 ? -16.93421 -15.45165 7.49809   1.000 15.86781 ? 518  ALA   B N   1 
ATOM   3345 C CA  . ALA   B 1 163 ? -17.98015 -15.28710 6.49618   1.000 16.71403 ? 518  ALA   B CA  1 
ATOM   3346 C C   . ALA   B 1 163 ? -18.34638 -13.81155 6.40348   1.000 14.55918 ? 518  ALA   B C   1 
ATOM   3347 O O   . ALA   B 1 163 ? -18.72452 -13.20562 7.41470   1.000 18.68673 ? 518  ALA   B O   1 
ATOM   3348 C CB  . ALA   B 1 163 ? -19.20989 -16.10409 6.90659   1.000 17.90644 ? 518  ALA   B CB  1 
ATOM   3349 N N   . LEU   B 1 164 ? -18.19895 -13.21508 5.23663   1.000 15.23680 ? 519  LEU   B N   1 
ATOM   3350 C CA  . LEU   B 1 164 ? -18.47873 -11.78923 5.17863   1.000 17.54869 ? 519  LEU   B CA  1 
ATOM   3351 C C   . LEU   B 1 164 ? -19.98086 -11.54856 5.32485   1.000 17.36423 ? 519  LEU   B C   1 
ATOM   3352 O O   . LEU   B 1 164 ? -20.81714 -12.31773 4.79670   1.000 16.59041 ? 519  LEU   B O   1 
ATOM   3353 C CB  . LEU   B 1 164 ? -18.01097 -11.17713 3.86723   1.000 16.29756 ? 519  LEU   B CB  1 
ATOM   3354 C CG  . LEU   B 1 164 ? -16.49184 -11.25323 3.66519   1.000 14.54418 ? 519  LEU   B CG  1 
ATOM   3355 C CD1 . LEU   B 1 164 ? -16.24008 -10.82900 2.19971   1.000 21.22936 ? 519  LEU   B CD1 1 
ATOM   3356 C CD2 . LEU   B 1 164 ? -15.87056 -10.30441 4.57078   1.000 17.89347 ? 519  LEU   B CD2 1 
ATOM   3357 N N   . ARG   B 1 165 ? -20.30255 -10.43132 5.96013   1.000 15.23734 ? 520  ARG   B N   1 
ATOM   3358 C CA  . ARG   B 1 165 ? -21.69394 -9.96092  6.01840   1.000 16.23808 ? 520  ARG   B CA  1 
ATOM   3359 C C   . ARG   B 1 165 ? -22.24115 -9.69869  4.64185   1.000 16.83232 ? 520  ARG   B C   1 
ATOM   3360 O O   . ARG   B 1 165 ? -21.54386 -9.26207  3.73308   1.000 16.20502 ? 520  ARG   B O   1 
ATOM   3361 C CB  . ARG   B 1 165 ? -21.78352 -8.65875  6.80389   1.000 17.53452 ? 520  ARG   B CB  1 
ATOM   3362 C CG  . ARG   B 1 165 ? -21.62727 -8.84282  8.25562   1.000 22.30630 ? 520  ARG   B CG  1 
ATOM   3363 C CD  . ARG   B 1 165 ? -21.41249 -7.47414  8.94811   1.000 26.64961 ? 520  ARG   B CD  1 
ATOM   3364 N NE  . ARG   B 1 165 ? -22.45941 -6.51175  8.59605   1.000 25.44982 ? 520  ARG   B NE  1 
ATOM   3365 C CZ  . ARG   B 1 165 ? -23.02599 -5.69490  9.47117   1.000 28.71172 ? 520  ARG   B CZ  1 
ATOM   3366 N NH1 . ARG   B 1 165 ? -22.75972 -5.77582  10.76538  1.000 36.09184 ? 520  ARG   B NH1 1 
ATOM   3367 N NH2 . ARG   B 1 165 ? -23.87009 -4.76632  9.03640   1.000 28.99562 ? 520  ARG   B NH2 1 
ATOM   3368 N N   . ALA   B 1 166 ? -23.55091 -9.84225  4.52032   1.000 14.12548 ? 521  ALA   B N   1 
ATOM   3369 C CA  . ALA   B 1 166 ? -24.17629 -9.66677  3.21487   1.000 14.27283 ? 521  ALA   B CA  1 
ATOM   3370 C C   . ALA   B 1 166 ? -24.02421 -8.24898  2.69138   1.000 17.85781 ? 521  ALA   B C   1 
ATOM   3371 O O   . ALA   B 1 166 ? -24.11725 -8.05444  1.46884   1.000 17.59878 ? 521  ALA   B O   1 
ATOM   3372 C CB  . ALA   B 1 166 ? -25.67792 -10.00039 3.31864   1.000 13.90727 ? 521  ALA   B CB  1 
ATOM   3373 N N   . ASP   B 1 167 ? -23.82197 -7.27667  3.58047   1.000 17.32312 ? 522  ASP   B N   1 
ATOM   3374 C CA  . ASP   B 1 167 ? -23.76667 -5.87954  3.17730   1.000 18.28603 ? 522  ASP   B CA  1 
ATOM   3375 C C   . ASP   B 1 167 ? -22.35568 -5.31899  3.16350   1.000 24.37069 ? 522  ASP   B C   1 
ATOM   3376 O O   . ASP   B 1 167 ? -22.20488 -4.09775  3.03260   1.000 23.56784 ? 522  ASP   B O   1 
ATOM   3377 C CB  . ASP   B 1 167 ? -24.63185 -5.02233  4.10651   1.000 19.95840 ? 522  ASP   B CB  1 
ATOM   3378 C CG  . ASP   B 1 167 ? -24.19004 -5.05439  5.58765   1.000 23.95591 ? 522  ASP   B CG  1 
ATOM   3379 O OD1 . ASP   B 1 167 ? -23.37826 -5.91541  5.99351   1.000 21.52327 ? 522  ASP   B OD1 1 
ATOM   3380 O OD2 . ASP   B 1 167 ? -24.68910 -4.22229  6.39994   1.000 26.47477 ? 522  ASP   B OD2 1 
ATOM   3381 N N   . GLU   B 1 168 ? -21.33071 -6.15006  3.30254   1.000 20.31077 ? 523  GLU   B N   1 
ATOM   3382 C CA  . GLU   B 1 168 ? -19.97469 -5.60609  3.39083   1.000 22.76059 ? 523  GLU   B CA  1 
ATOM   3383 C C   . GLU   B 1 168 ? -19.02962 -6.47138  2.59999   1.000 19.33170 ? 523  GLU   B C   1 
ATOM   3384 O O   . GLU   B 1 168 ? -19.16561 -7.68876  2.51540   1.000 19.64348 ? 523  GLU   B O   1 
ATOM   3385 C CB  . GLU   B 1 168 ? -19.42764 -5.55194  4.80731   1.000 23.57753 ? 523  GLU   B CB  1 
ATOM   3386 C CG  . GLU   B 1 168 ? -20.11975 -4.56171  5.74001   1.000 25.69230 ? 523  GLU   B CG  1 
ATOM   3387 C CD  . GLU   B 1 168 ? -19.63322 -4.65406  7.18960   1.000 46.08769 ? 523  GLU   B CD  1 
ATOM   3388 O OE1 . GLU   B 1 168 ? -18.63709 -5.37627  7.47852   1.000 48.94377 ? 523  GLU   B OE1 1 
ATOM   3389 O OE2 . GLU   B 1 168 ? -20.26527 -3.99803  8.05179   1.000 60.06788 ? 523  GLU   B OE2 1 
ATOM   3390 N N   . ASN   B 1 169 ? -18.00634 -5.83577  2.06583   1.000 19.04597 ? 524  ASN   B N   1 
ATOM   3391 C CA  . ASN   B 1 169 ? -17.01330 -6.56361  1.31606   1.000 22.01432 ? 524  ASN   B CA  1 
ATOM   3392 C C   . ASN   B 1 169 ? -15.76497 -6.85178  2.12260   1.000 19.86220 ? 524  ASN   B C   1 
ATOM   3393 O O   . ASN   B 1 169 ? -14.78270 -7.31621  1.55884   1.000 23.46034 ? 524  ASN   B O   1 
ATOM   3394 C CB  . ASN   B 1 169 ? -16.63861 -5.77005  0.06024   1.000 24.85234 ? 524  ASN   B CB  1 
ATOM   3395 C CG  . ASN   B 1 169 ? -16.31670 -6.66782  -1.09249  1.000 35.36079 ? 524  ASN   B CG  1 
ATOM   3396 O OD1 . ASN   B 1 169 ? -16.96069 -7.70418  -1.27507  1.000 45.74501 ? 524  ASN   B OD1 1 
ATOM   3397 N ND2 . ASN   B 1 169 ? -15.30966 -6.29435  -1.87522  1.000 58.05221 ? 524  ASN   B ND2 1 
ATOM   3398 N N   . TYR   B 1 170 ? -15.75925 -6.54976  3.41393   1.000 15.94281 ? 525  TYR   B N   1 
ATOM   3399 C CA  . TYR   B 1 170 ? -14.62819 -6.83347  4.27795   1.000 19.69564 ? 525  TYR   B CA  1 
ATOM   3400 C C   . TYR   B 1 170 ? -15.13615 -7.20732  5.65298   1.000 21.36928 ? 525  TYR   B C   1 
ATOM   3401 O O   . TYR   B 1 170 ? -16.31386 -7.00799  5.98263   1.000 21.04778 ? 525  TYR   B O   1 
ATOM   3402 C CB  . TYR   B 1 170 ? -13.71448 -5.62856  4.39973   1.000 19.13548 ? 525  TYR   B CB  1 
ATOM   3403 C CG  . TYR   B 1 170 ? -14.44637 -4.43570  4.94738   1.000 23.36835 ? 525  TYR   B CG  1 
ATOM   3404 C CD1 . TYR   B 1 170 ? -15.13051 -3.58087  4.10643   1.000 26.22858 ? 525  TYR   B CD1 1 
ATOM   3405 C CD2 . TYR   B 1 170 ? -14.43191 -4.16504  6.31038   1.000 25.07247 ? 525  TYR   B CD2 1 
ATOM   3406 C CE1 . TYR   B 1 170 ? -15.80547 -2.48304  4.62232   1.000 34.11758 ? 525  TYR   B CE1 1 
ATOM   3407 C CE2 . TYR   B 1 170 ? -15.08602 -3.08228  6.82754   1.000 37.89660 ? 525  TYR   B CE2 1 
ATOM   3408 C CZ  . TYR   B 1 170 ? -15.77474 -2.25026  5.98814   1.000 32.47670 ? 525  TYR   B CZ  1 
ATOM   3409 O OH  . TYR   B 1 170 ? -16.40945 -1.17114  6.56187   1.000 42.80088 ? 525  TYR   B OH  1 
ATOM   3410 N N   . TYR   B 1 171 ? -14.25046 -7.83181  6.41308   1.000 15.50755 ? 526  TYR   B N   1 
ATOM   3411 C CA  . TYR   B 1 171 ? -14.39977 -8.08917  7.84235   1.000 15.28934 ? 526  TYR   B CA  1 
ATOM   3412 C C   . TYR   B 1 171 ? -13.52661 -7.10067  8.62017   1.000 16.66394 ? 526  TYR   B C   1 
ATOM   3413 O O   . TYR   B 1 171 ? -12.32250 -6.92694  8.31954   1.000 17.48226 ? 526  TYR   B O   1 
ATOM   3414 C CB  . TYR   B 1 171 ? -13.97604 -9.52865  8.15262   1.000 16.00603 ? 526  TYR   B CB  1 
ATOM   3415 C CG  . TYR   B 1 171 ? -13.78152 -9.78155  9.61756   1.000 16.23508 ? 526  TYR   B CG  1 
ATOM   3416 C CD1 . TYR   B 1 171 ? -14.87039 -10.02500 10.44641  1.000 20.65440 ? 526  TYR   B CD1 1 
ATOM   3417 C CD2 . TYR   B 1 171 ? -12.50601 -9.84893  10.17610  1.000 16.65319 ? 526  TYR   B CD2 1 
ATOM   3418 C CE1 . TYR   B 1 171 ? -14.67727 -10.26044 11.80498  1.000 20.95393 ? 526  TYR   B CE1 1 
ATOM   3419 C CE2 . TYR   B 1 171 ? -12.31234 -10.07459 11.50354  1.000 22.77574 ? 526  TYR   B CE2 1 
ATOM   3420 C CZ  . TYR   B 1 171 ? -13.40370 -10.29481 12.31823  1.000 25.66239 ? 526  TYR   B CZ  1 
ATOM   3421 O OH  . TYR   B 1 171 ? -13.19004 -10.50567 13.65887  1.000 29.25407 ? 526  TYR   B OH  1 
ATOM   3422 N N   . LYS   B 1 172 ? -14.11981 -6.42388  9.60083   1.000 18.66955 ? 527  LYS   B N   1 
ATOM   3423 C CA  . LYS   B 1 172 ? -13.39980 -5.49221  10.44800  1.000 19.70815 ? 527  LYS   B CA  1 
ATOM   3424 C C   . LYS   B 1 172 ? -13.06205 -6.16311  11.77002  1.000 20.85988 ? 527  LYS   B C   1 
ATOM   3425 O O   . LYS   B 1 172 ? -13.96969 -6.58758  12.51789  1.000 25.61696 ? 527  LYS   B O   1 
ATOM   3426 C CB  . LYS   B 1 172 ? -14.24107 -4.22795  10.66750  1.000 24.39299 ? 527  LYS   B CB  1 
ATOM   3427 C CG  . LYS   B 1 172 ? -13.68801 -3.33349  11.75908  1.000 30.41878 ? 527  LYS   B CG  1 
ATOM   3428 C CD  . LYS   B 1 172 ? -12.45549 -2.61088  11.26253  1.000 29.18414 ? 527  LYS   B CD  1 
ATOM   3429 C CE  . LYS   B 1 172 ? -12.40491 -1.16894  11.76870  1.000 36.54436 ? 527  LYS   B CE  1 
ATOM   3430 N NZ  . LYS   B 1 172 ? -11.81687 -1.07052  13.12516  1.000 42.70409 ? 527  LYS   B NZ  1 
ATOM   3431 N N   . ALA   B 1 173 ? -11.77447 -6.29994  12.04395  1.000 20.64248 ? 528  ALA   B N   1 
ATOM   3432 C CA  . ALA   B 1 173 ? -11.33250 -6.88778  13.30145  1.000 22.46693 ? 528  ALA   B CA  1 
ATOM   3433 C C   . ALA   B 1 173 ? -11.39064 -5.86418  14.42260  1.000 26.86033 ? 528  ALA   B C   1 
ATOM   3434 O O   . ALA   B 1 173 ? -11.33142 -4.65760  14.19106  1.000 29.51870 ? 528  ALA   B O   1 
ATOM   3435 C CB  . ALA   B 1 173 ? -9.90396  -7.42853  13.20730  1.000 26.07342 ? 528  ALA   B CB  1 
ATOM   3436 N N   . GLN   B 1 174 ? -11.51032 -6.37006  15.65153  1.000 33.99058 ? 529  GLN   B N   1 
ATOM   3437 C CA  . GLN   B 1 174 ? -11.46484 -5.52668  16.85262  1.000 42.47525 ? 529  GLN   B CA  1 
ATOM   3438 C C   . GLN   B 1 174 ? -10.27456 -5.94229  17.71827  1.000 43.82193 ? 529  GLN   B C   1 
ATOM   3439 O O   . GLN   B 1 174 ? -9.15234  -5.47968  17.51495  1.000 50.39284 ? 529  GLN   B O   1 
ATOM   3440 C CB  . GLN   B 1 174 ? -12.76392 -5.62818  17.67081  1.000 39.94485 ? 529  GLN   B CB  1 
ATOM   3441 C CG  . GLN   B 1 174 ? -14.04036 -5.64032  16.87209  1.000 35.22593 ? 529  GLN   B CG  1 
ATOM   3442 C CD  . GLN   B 1 174 ? -14.48905 -4.26178  16.43952  1.000 54.23345 ? 529  GLN   B CD  1 
ATOM   3443 O OE1 . GLN   B 1 174 ? -14.47815 -3.31586  17.22993  1.000 66.16514 ? 529  GLN   B OE1 1 
ATOM   3444 N NE2 . GLN   B 1 174 ? -14.88838 -4.13592  15.17032  1.000 49.97091 ? 529  GLN   B NE2 1 
ATOM   3445 N N   . LYS   B 1 178 ? -2.24688  -12.51756 18.36972  1.000 46.35439 ? 533  LYS   B N   1 
ATOM   3446 C CA  . LYS   B 1 178 ? -1.10702  -12.74137 17.48825  1.000 42.67157 ? 533  LYS   B CA  1 
ATOM   3447 C C   . LYS   B 1 178 ? -1.58320  -12.86301 16.04083  1.000 36.21701 ? 533  LYS   B C   1 
ATOM   3448 O O   . LYS   B 1 178 ? -2.36373  -13.75156 15.72019  1.000 38.59179 ? 533  LYS   B O   1 
ATOM   3449 C CB  . LYS   B 1 178 ? -0.34030  -14.00763 17.89806  1.000 43.86742 ? 533  LYS   B CB  1 
ATOM   3450 C CG  . LYS   B 1 178 ? 0.96440   -14.22439 17.12719  1.000 49.67869 ? 533  LYS   B CG  1 
ATOM   3451 C CD  . LYS   B 1 178 ? 0.98165   -15.56816 16.39974  1.000 47.59265 ? 533  LYS   B CD  1 
ATOM   3452 C CE  . LYS   B 1 178 ? 2.38830   -16.14728 16.36007  1.000 56.92267 ? 533  LYS   B CE  1 
ATOM   3453 N NZ  . LYS   B 1 178 ? 2.42154   -17.54838 15.84285  1.000 56.09247 ? 533  LYS   B NZ  1 
ATOM   3454 N N   . TRP   B 1 179 ? -1.10985  -11.95969 15.16988  1.000 34.80271 ? 534  TRP   B N   1 
ATOM   3455 C CA  . TRP   B 1 179 ? -1.46872  -12.00524 13.76290  1.000 27.57052 ? 534  TRP   B CA  1 
ATOM   3456 C C   . TRP   B 1 179 ? -0.26624  -12.42945 12.91614  1.000 24.89816 ? 534  TRP   B C   1 
ATOM   3457 O O   . TRP   B 1 179 ? 0.87760   -12.14147 13.28243  1.000 26.23837 ? 534  TRP   B O   1 
ATOM   3458 C CB  . TRP   B 1 179 ? -1.95697  -10.63527 13.27815  1.000 25.10595 ? 534  TRP   B CB  1 
ATOM   3459 C CG  . TRP   B 1 179 ? -3.41749  -10.38423 13.46642  1.000 30.45308 ? 534  TRP   B CG  1 
ATOM   3460 C CD1 . TRP   B 1 179 ? -4.36719  -11.26882 13.94363  1.000 26.22145 ? 534  TRP   B CD1 1 
ATOM   3461 C CD2 . TRP   B 1 179 ? -4.11128  -9.15550  13.19455  1.000 22.61834 ? 534  TRP   B CD2 1 
ATOM   3462 N NE1 . TRP   B 1 179 ? -5.60589  -10.65382 13.97159  1.000 29.91977 ? 534  TRP   B NE1 1 
ATOM   3463 C CE2 . TRP   B 1 179 ? -5.47723  -9.36759  13.51638  1.000 25.43975 ? 534  TRP   B CE2 1 
ATOM   3464 C CE3 . TRP   B 1 179 ? -3.72278  -7.90861  12.69316  1.000 22.66113 ? 534  TRP   B CE3 1 
ATOM   3465 C CZ2 . TRP   B 1 179 ? -6.44466  -8.37300  13.36173  1.000 25.34941 ? 534  TRP   B CZ2 1 
ATOM   3466 C CZ3 . TRP   B 1 179 ? -4.69965  -6.91135  12.54549  1.000 24.38551 ? 534  TRP   B CZ3 1 
ATOM   3467 C CH2 . TRP   B 1 179 ? -6.04093  -7.16785  12.86351  1.000 23.18414 ? 534  TRP   B CH2 1 
ATOM   3468 N N   . PRO   B 1 180 ? -0.49404  -13.10338 11.77746  1.000 21.13531 ? 535  PRO   B N   1 
ATOM   3469 C CA  . PRO   B 1 180 ? 0.62820   -13.43140 10.84701  1.000 23.15991 ? 535  PRO   B CA  1 
ATOM   3470 C C   . PRO   B 1 180 ? 0.98850   -12.23429 9.96606   1.000 22.62014 ? 535  PRO   B C   1 
ATOM   3471 O O   . PRO   B 1 180 ? 0.77098   -12.21283 8.74794   1.000 17.62166 ? 535  PRO   B O   1 
ATOM   3472 C CB  . PRO   B 1 180 ? 0.05093   -14.60197 10.04976  1.000 22.00749 ? 535  PRO   B CB  1 
ATOM   3473 C CG  . PRO   B 1 180 ? -1.43480  -14.29840 9.97372   1.000 21.08797 ? 535  PRO   B CG  1 
ATOM   3474 C CD  . PRO   B 1 180 ? -1.77303  -13.68675 11.32137  1.000 17.72864 ? 535  PRO   B CD  1 
ATOM   3475 N N   . VAL   B 1 181 ? 1.55415   -11.19764 10.58951  1.000 17.88222 ? 536  VAL   B N   1 
ATOM   3476 C CA  . VAL   B 1 181 ? 1.64654   -9.90085  9.92584   1.000 19.75732 ? 536  VAL   B CA  1 
ATOM   3477 C C   . VAL   B 1 181 ? 2.53670   -9.90121  8.68702   1.000 18.05203 ? 536  VAL   B C   1 
ATOM   3478 O O   . VAL   B 1 181 ? 2.31949   -9.07728  7.78875   1.000 15.05229 ? 536  VAL   B O   1 
ATOM   3479 C CB  . VAL   B 1 181 ? 2.11149   -8.81830  10.90378  1.000 26.66253 ? 536  VAL   B CB  1 
ATOM   3480 C CG1 . VAL   B 1 181 ? 1.09085   -8.71299  12.04603  1.000 24.44670 ? 536  VAL   B CG1 1 
ATOM   3481 C CG2 . VAL   B 1 181 ? 3.48811   -9.11630  11.39294  1.000 24.97861 ? 536  VAL   B CG2 1 
ATOM   3482 N N   . LYS   B 1 182 ? 3.50132   -10.82294 8.58525   1.000 14.31126 ? 537  LYS   B N   1 
ATOM   3483 C CA  . LYS   B 1 182 ? 4.30979   -10.86812 7.36022   1.000 16.79079 ? 537  LYS   B CA  1 
ATOM   3484 C C   . LYS   B 1 182 ? 3.47546   -11.28647 6.16596   1.000 14.26065 ? 537  LYS   B C   1 
ATOM   3485 O O   . LYS   B 1 182 ? 3.89940   -11.10168 5.02542   1.000 12.80011 ? 537  LYS   B O   1 
ATOM   3486 C CB  . LYS   B 1 182 ? 5.50411   -11.82646 7.53213   1.000 14.16936 ? 537  LYS   B CB  1 
ATOM   3487 C CG  . LYS   B 1 182 ? 6.63090   -11.15957 8.35168   1.000 14.83621 ? 537  LYS   B CG  1 
ATOM   3488 C CD  . LYS   B 1 182 ? 7.78164   -12.07644 8.66732   1.000 20.20653 ? 537  LYS   B CD  1 
ATOM   3489 C CE  . LYS   B 1 182 ? 8.78408   -11.19832 9.40666   1.000 22.60579 ? 537  LYS   B CE  1 
ATOM   3490 N NZ  . LYS   B 1 182 ? 9.87725   -12.08858 9.93573   1.000 28.66352 ? 537  LYS   B NZ  1 
ATOM   3491 N N   . TRP   B 1 183 ? 2.26590   -11.78392 6.39109   1.000 10.98183 ? 538  TRP   B N   1 
ATOM   3492 C CA  . TRP   B 1 183 ? 1.41016   -12.14678 5.29288   1.000 11.67756 ? 538  TRP   B CA  1 
ATOM   3493 C C   . TRP   B 1 183 ? 0.29070   -11.14111 5.04993   1.000 11.81390 ? 538  TRP   B C   1 
ATOM   3494 O O   . TRP   B 1 183 ? -0.50084  -11.34186 4.10359   1.000 13.42049 ? 538  TRP   B O   1 
ATOM   3495 C CB  . TRP   B 1 183 ? 0.80247   -13.54562 5.48133   1.000 11.55018 ? 538  TRP   B CB  1 
ATOM   3496 C CG  . TRP   B 1 183 ? 1.80866   -14.64445 5.26909   1.000 10.67532 ? 538  TRP   B CG  1 
ATOM   3497 C CD1 . TRP   B 1 183 ? 1.91676   -15.44777 4.13469   1.000 11.58936 ? 538  TRP   B CD1 1 
ATOM   3498 C CD2 . TRP   B 1 183 ? 2.83463   -15.09139 6.18950   1.000 11.88685 ? 538  TRP   B CD2 1 
ATOM   3499 N NE1 . TRP   B 1 183 ? 2.99211   -16.32063 4.30980   1.000 12.63305 ? 538  TRP   B NE1 1 
ATOM   3500 C CE2 . TRP   B 1 183 ? 3.54569   -16.14947 5.54156   1.000 12.95188 ? 538  TRP   B CE2 1 
ATOM   3501 C CE3 . TRP   B 1 183 ? 3.21879   -14.71367 7.48770   1.000 13.08521 ? 538  TRP   B CE3 1 
ATOM   3502 C CZ2 . TRP   B 1 183 ? 4.62554   -16.81687 6.12731   1.000 12.22960 ? 538  TRP   B CZ2 1 
ATOM   3503 C CZ3 . TRP   B 1 183 ? 4.31304   -15.39817 8.10068   1.000 14.74887 ? 538  TRP   B CZ3 1 
ATOM   3504 C CH2 . TRP   B 1 183 ? 5.01025   -16.42892 7.39550   1.000 14.62993 ? 538  TRP   B CH2 1 
ATOM   3505 N N   . TYR   B 1 184 ? 0.20915   -10.09128 5.86333   1.000 14.07673 ? 539  TYR   B N   1 
ATOM   3506 C CA  . TYR   B 1 184 ? -0.95694  -9.21980  5.82154   1.000 15.46614 ? 539  TYR   B CA  1 
ATOM   3507 C C   . TYR   B 1 184 ? -0.74682  -7.95733  4.99214   1.000 15.43982 ? 539  TYR   B C   1 
ATOM   3508 O O   . TYR   B 1 184 ? 0.32873   -7.32147  5.01643   1.000 16.89886 ? 539  TYR   B O   1 
ATOM   3509 C CB  . TYR   B 1 184 ? -1.36557  -8.84068  7.24067   1.000 14.78124 ? 539  TYR   B CB  1 
ATOM   3510 C CG  . TYR   B 1 184 ? -2.25261  -9.86653  7.91235   1.000 14.90302 ? 539  TYR   B CG  1 
ATOM   3511 C CD1 . TYR   B 1 184 ? -2.61940  -11.06818 7.28354   1.000 19.43097 ? 539  TYR   B CD1 1 
ATOM   3512 C CD2 . TYR   B 1 184 ? -2.68968  -9.63023  9.18933   1.000 17.48065 ? 539  TYR   B CD2 1 
ATOM   3513 C CE1 . TYR   B 1 184 ? -3.46574  -12.01391 7.92797   1.000 19.84036 ? 539  TYR   B CE1 1 
ATOM   3514 C CE2 . TYR   B 1 184 ? -3.52820  -10.53896 9.84572   1.000 16.72663 ? 539  TYR   B CE2 1 
ATOM   3515 C CZ  . TYR   B 1 184 ? -3.91643  -11.71637 9.21382   1.000 18.54132 ? 539  TYR   B CZ  1 
ATOM   3516 O OH  . TYR   B 1 184 ? -4.73628  -12.59608 9.90363   1.000 19.07572 ? 539  TYR   B OH  1 
ATOM   3517 N N   . ALA   B 1 185 ? -1.81389  -7.56432  4.29479   1.000 12.92498 ? 540  ALA   B N   1 
ATOM   3518 C CA  . ALA   B 1 185 ? -1.79465  -6.39040  3.47361   1.000 13.83362 ? 540  ALA   B CA  1 
ATOM   3519 C C   . ALA   B 1 185 ? -1.78277  -5.12215  4.33569   1.000 16.02101 ? 540  ALA   B C   1 
ATOM   3520 O O   . ALA   B 1 185 ? -2.12012  -5.15617  5.52857   1.000 14.89890 ? 540  ALA   B O   1 
ATOM   3521 C CB  . ALA   B 1 185 ? -3.00319  -6.38944  2.55807   1.000 13.30140 ? 540  ALA   B CB  1 
ATOM   3522 N N   . PRO   B 1 186 ? -1.35536  -3.99835  3.76363   1.000 15.42509 ? 541  PRO   B N   1 
ATOM   3523 C CA  . PRO   B 1 186 ? -1.30426  -2.74966  4.55616   1.000 15.13879 ? 541  PRO   B CA  1 
ATOM   3524 C C   . PRO   B 1 186 ? -2.64065  -2.36191  5.15464   1.000 18.52927 ? 541  PRO   B C   1 
ATOM   3525 O O   . PRO   B 1 186 ? -2.64840  -1.89197  6.30075   1.000 19.06160 ? 541  PRO   B O   1 
ATOM   3526 C CB  . PRO   B 1 186 ? -0.81813  -1.70939  3.54138   1.000 20.31089 ? 541  PRO   B CB  1 
ATOM   3527 C CG  . PRO   B 1 186 ? 0.03115   -2.52554  2.56429   1.000 19.21613 ? 541  PRO   B CG  1 
ATOM   3528 C CD  . PRO   B 1 186 ? -0.71919  -3.86348  2.44421   1.000 16.45779 ? 541  PRO   B CD  1 
ATOM   3529 N N   . GLU   B 1 187 ? -3.75147  -2.56239  4.44643   1.000 14.89688 ? 542  GLU   B N   1 
ATOM   3530 C CA  . GLU   B 1 187 ? -5.05106  -2.16512  5.01534   1.000 15.87286 ? 542  GLU   B CA  1 
ATOM   3531 C C   . GLU   B 1 187 ? -5.41268  -3.03936  6.21108   1.000 19.65875 ? 542  GLU   B C   1 
ATOM   3532 O O   . GLU   B 1 187 ? -6.14557  -2.59154  7.10404   1.000 16.55340 ? 542  GLU   B O   1 
ATOM   3533 C CB  . GLU   B 1 187 ? -6.14775  -2.19838  3.97206   1.000 17.70147 ? 542  GLU   B CB  1 
ATOM   3534 C CG  . GLU   B 1 187 ? -6.60151  -3.57964  3.45093   1.000 17.65701 ? 542  GLU   B CG  1 
ATOM   3535 C CD  . GLU   B 1 187 ? -5.74922  -4.14828  2.29970   1.000 18.01187 ? 542  GLU   B CD  1 
ATOM   3536 O OE1 . GLU   B 1 187 ? -4.72814  -3.48629  1.87408   1.000 16.96399 ? 542  GLU   B OE1 1 
ATOM   3537 O OE2 . GLU   B 1 187 ? -6.08612  -5.28836  1.86035   1.000 16.26396 ? 542  GLU   B OE2 1 
ATOM   3538 N N   . CYS   B 1 188 ? -4.88643  -4.25577  6.27094   1.000 18.67113 ? 543  CYS   B N   1 
ATOM   3539 C CA  . CYS   B 1 188 ? -5.12654  -5.09449  7.44415   1.000 18.34433 ? 543  CYS   B CA  1 
ATOM   3540 C C   . CYS   B 1 188 ? -4.42903  -4.50552  8.66105   1.000 18.19238 ? 543  CYS   B C   1 
ATOM   3541 O O   . CYS   B 1 188 ? -4.99524  -4.39993  9.76346   1.000 18.31119 ? 543  CYS   B O   1 
ATOM   3542 C CB  . CYS   B 1 188 ? -4.61079  -6.52521  7.17930   1.000 13.85418 ? 543  CYS   B CB  1 
ATOM   3543 S SG  . CYS   B 1 188 ? -5.23680  -7.23920  5.70636   1.000 19.36721 ? 543  CYS   B SG  1 
ATOM   3544 N N   . ILE   B 1 189 ? -3.18348  -4.10374  8.47799   1.000 17.95208 ? 544  ILE   B N   1 
ATOM   3545 C CA  . ILE   B 1 189 ? -2.38926  -3.55269  9.55520   1.000 19.51155 ? 544  ILE   B CA  1 
ATOM   3546 C C   . ILE   B 1 189 ? -2.90352  -2.17133  9.97915   1.000 20.89786 ? 544  ILE   B C   1 
ATOM   3547 O O   . ILE   B 1 189 ? -2.97723  -1.84699  11.18227  1.000 23.96420 ? 544  ILE   B O   1 
ATOM   3548 C CB  . ILE   B 1 189 ? -0.91781  -3.51572  9.09518   1.000 19.27725 ? 544  ILE   B CB  1 
ATOM   3549 C CG1 . ILE   B 1 189 ? -0.45518  -4.93602  8.64349   1.000 19.22376 ? 544  ILE   B CG1 1 
ATOM   3550 C CG2 . ILE   B 1 189 ? -0.02992  -2.98671  10.19935  1.000 28.23428 ? 544  ILE   B CG2 1 
ATOM   3551 C CD1 . ILE   B 1 189 ? -0.56984  -6.00495  9.73320   1.000 24.42746 ? 544  ILE   B CD1 1 
ATOM   3552 N N   . ASN   B 1 190 ? -3.28435  -1.34751  9.02149   1.000 17.35218 ? 545  ASN   B N   1 
ATOM   3553 C CA  . ASN   B 1 190 ? -3.56502  0.05879   9.29085   1.000 17.97627 ? 545  ASN   B CA  1 
ATOM   3554 C C   . ASN   B 1 190 ? -5.03091  0.33167   9.58007   1.000 17.08385 ? 545  ASN   B C   1 
ATOM   3555 O O   . ASN   B 1 190 ? -5.33426  1.32104   10.26327  1.000 21.97119 ? 545  ASN   B O   1 
ATOM   3556 C CB  . ASN   B 1 190 ? -3.15885  0.89619   8.07478   1.000 20.68148 ? 545  ASN   B CB  1 
ATOM   3557 C CG  . ASN   B 1 190 ? -1.65802  1.00132   7.91783   1.000 21.13061 ? 545  ASN   B CG  1 
ATOM   3558 O OD1 . ASN   B 1 190 ? -0.91989  0.87958   8.88072   1.000 27.26100 ? 545  ASN   B OD1 1 
ATOM   3559 N ND2 . ASN   B 1 190 ? -1.20516  1.18485   6.69191   1.000 25.61609 ? 545  ASN   B ND2 1 
ATOM   3560 N N   . TYR   B 1 191 ? -5.94370  -0.48877  9.10655   1.000 17.32082 ? 546  TYR   B N   1 
ATOM   3561 C CA  . TYR   B 1 191 ? -7.36711  -0.24349  9.28131   1.000 18.08043 ? 546  TYR   B CA  1 
ATOM   3562 C C   . TYR   B 1 191 ? -8.09545  -1.45850  9.85011   1.000 19.68594 ? 546  TYR   B C   1 
ATOM   3563 O O   . TYR   B 1 191 ? -9.31701  -1.38617  10.06646  1.000 18.99420 ? 546  TYR   B O   1 
ATOM   3564 C CB  . TYR   B 1 191 ? -8.01208  0.17686   7.95994   1.000 16.99814 ? 546  TYR   B CB  1 
ATOM   3565 C CG  . TYR   B 1 191 ? -7.42504  1.44716   7.35660   1.000 18.12304 ? 546  TYR   B CG  1 
ATOM   3566 C CD1 . TYR   B 1 191 ? -7.76249  2.68984   7.87536   1.000 24.10715 ? 546  TYR   B CD1 1 
ATOM   3567 C CD2 . TYR   B 1 191 ? -6.53850  1.38921   6.29767   1.000 20.87752 ? 546  TYR   B CD2 1 
ATOM   3568 C CE1 . TYR   B 1 191 ? -7.20772  3.83833   7.35744   1.000 22.88824 ? 546  TYR   B CE1 1 
ATOM   3569 C CE2 . TYR   B 1 191 ? -6.01394  2.54571   5.75138   1.000 24.32077 ? 546  TYR   B CE2 1 
ATOM   3570 C CZ  . TYR   B 1 191 ? -6.36666  3.75453   6.28324   1.000 24.08286 ? 546  TYR   B CZ  1 
ATOM   3571 O OH  . TYR   B 1 191 ? -5.84697  4.93054   5.73829   1.000 23.53574 ? 546  TYR   B OH  1 
ATOM   3572 N N   . TYR   B 1 192 ? -7.39908  -2.58316  10.01494  1.000 16.65888 ? 547  TYR   B N   1 
ATOM   3573 C CA  . TYR   B 1 192 ? -8.00719  -3.83835  10.51163  1.000 15.53057 ? 547  TYR   B CA  1 
ATOM   3574 C C   . TYR   B 1 192 ? -9.10701  -4.34480  9.58303   1.000 17.41665 ? 547  TYR   B C   1 
ATOM   3575 O O   . TYR   B 1 192 ? -10.04214 -5.00947  10.03816  1.000 18.87724 ? 547  TYR   B O   1 
ATOM   3576 C CB  . TYR   B 1 192 ? -8.55496  -3.66951  11.94254  1.000 18.64980 ? 547  TYR   B CB  1 
ATOM   3577 C CG  . TYR   B 1 192 ? -7.53964  -3.41514  13.02958  1.000 25.45493 ? 547  TYR   B CG  1 
ATOM   3578 C CD1 . TYR   B 1 192 ? -6.20375  -3.17854  12.75849  1.000 28.50042 ? 547  TYR   B CD1 1 
ATOM   3579 C CD2 . TYR   B 1 192 ? -7.93629  -3.41511  14.36403  1.000 47.27845 ? 547  TYR   B CD2 1 
ATOM   3580 C CE1 . TYR   B 1 192 ? -5.29022  -2.92655  13.79063  1.000 40.59880 ? 547  TYR   B CE1 1 
ATOM   3581 C CE2 . TYR   B 1 192 ? -7.03495  -3.17772  15.39288  1.000 47.00057 ? 547  TYR   B CE2 1 
ATOM   3582 C CZ  . TYR   B 1 192 ? -5.71566  -2.93609  15.09881  1.000 52.90350 ? 547  TYR   B CZ  1 
ATOM   3583 O OH  . TYR   B 1 192 ? -4.82590  -2.70029  16.12126  1.000 55.99005 ? 547  TYR   B OH  1 
ATOM   3584 N N   . LYS   B 1 193 ? -9.00413  -4.10672  8.27445   1.000 15.36008 ? 548  LYS   B N   1 
ATOM   3585 C CA  . LYS   B 1 193 ? -10.02171 -4.46460  7.29170   1.000 17.75484 ? 548  LYS   B CA  1 
ATOM   3586 C C   . LYS   B 1 193 ? -9.49553  -5.61824  6.44463   1.000 16.91602 ? 548  LYS   B C   1 
ATOM   3587 O O   . LYS   B 1 193 ? -8.41867  -5.51400  5.81949   1.000 18.52941 ? 548  LYS   B O   1 
ATOM   3588 C CB  . LYS   B 1 193 ? -10.41428 -3.28255  6.39321   1.000 17.89215 ? 548  LYS   B CB  1 
ATOM   3589 C CG  . LYS   B 1 193 ? -11.03301 -2.13380  7.22016   1.000 21.89988 ? 548  LYS   B CG  1 
ATOM   3590 C CD  . LYS   B 1 193 ? -11.44506 -0.95196  6.31908   1.000 28.99627 ? 548  LYS   B CD  1 
ATOM   3591 C CE  . LYS   B 1 193 ? -12.36312 -1.38456  5.18118   1.000 28.86565 ? 548  LYS   B CE  1 
ATOM   3592 N NZ  . LYS   B 1 193 ? -12.42206 -0.33110  4.10766   1.000 45.78875 ? 548  LYS   B NZ  1 
ATOM   3593 N N   . PHE   B 1 194 ? -10.23819 -6.71743  6.43480   1.000 15.64923 ? 549  PHE   B N   1 
ATOM   3594 C CA  . PHE   B 1 194 ? -9.82824  -7.94401  5.75122   1.000 14.41312 ? 549  PHE   B CA  1 
ATOM   3595 C C   . PHE   B 1 194 ? -10.83405 -8.30035  4.67647   1.000 16.56086 ? 549  PHE   B C   1 
ATOM   3596 O O   . PHE   B 1 194 ? -12.00585 -8.55411  4.97657   1.000 19.37462 ? 549  PHE   B O   1 
ATOM   3597 C CB  . PHE   B 1 194 ? -9.71661  -9.10729  6.74950   1.000 15.06502 ? 549  PHE   B CB  1 
ATOM   3598 C CG  . PHE   B 1 194 ? -8.66340  -8.91547  7.78474   1.000 13.16756 ? 549  PHE   B CG  1 
ATOM   3599 C CD1 . PHE   B 1 194 ? -8.88740  -8.12158  8.89447   1.000 14.50911 ? 549  PHE   B CD1 1 
ATOM   3600 C CD2 . PHE   B 1 194 ? -7.42394  -9.54881  7.64034   1.000 16.22855 ? 549  PHE   B CD2 1 
ATOM   3601 C CE1 . PHE   B 1 194 ? -7.89937  -7.94528  9.80218   1.000 14.18457 ? 549  PHE   B CE1 1 
ATOM   3602 C CE2 . PHE   B 1 194 ? -6.43007  -9.39737  8.55278   1.000 17.36662 ? 549  PHE   B CE2 1 
ATOM   3603 C CZ  . PHE   B 1 194 ? -6.64976  -8.59127  9.64224   1.000 16.63993 ? 549  PHE   B CZ  1 
ATOM   3604 N N   . SER   B 1 195 ? -10.38866 -8.35450  3.42950   1.000 15.74936 ? 550  SER   B N   1 
ATOM   3605 C CA  . SER   B 1 195 ? -11.22857 -8.58513  2.26040   1.000 16.59058 ? 550  SER   B CA  1 
ATOM   3606 C C   . SER   B 1 195 ? -10.58959 -9.69808  1.44903   1.000 14.96382 ? 550  SER   B C   1 
ATOM   3607 O O   . SER   B 1 195 ? -9.46758  -10.13528 1.76163   1.000 15.50475 ? 550  SER   B O   1 
ATOM   3608 C CB  . SER   B 1 195 ? -11.34917 -7.32628  1.40394   1.000 17.73310 ? 550  SER   B CB  1 
ATOM   3609 O OG  . SER   B 1 195 ? -9.99224  -6.97489  1.03318   1.000 17.27788 ? 550  SER   B OG  1 
ATOM   3610 N N   . SER   B 1 196 ? -11.27947 -10.18032 0.40816   1.000 15.34797 ? 551  SER   B N   1 
ATOM   3611 C CA  . SER   B 1 196 ? -10.61960 -11.11824 -0.50058  1.000 14.50404 ? 551  SER   B CA  1 
ATOM   3612 C C   . SER   B 1 196 ? -9.36377  -10.51453 -1.12465  1.000 16.11493 ? 551  SER   B C   1 
ATOM   3613 O O   . SER   B 1 196 ? -8.37297  -11.23988 -1.32512  1.000 14.86041 ? 551  SER   B O   1 
ATOM   3614 C CB  . SER   B 1 196 ? -11.56589 -11.58836 -1.58670  1.000 15.88305 ? 551  SER   B CB  1 
ATOM   3615 O OG  . SER   B 1 196 ? -12.53558 -12.45871 -0.97911  1.000 22.90727 ? 551  SER   B OG  1 
ATOM   3616 N N   . LYS   B 1 197 ? -9.38703  -9.20240  -1.41894  1.000 14.74673 ? 552  LYS   B N   1 
ATOM   3617 C CA  . LYS   B 1 197 ? -8.16738  -8.51442  -1.88661  1.000 15.30686 ? 552  LYS   B CA  1 
ATOM   3618 C C   . LYS   B 1 197 ? -7.04202  -8.60604  -0.85838  1.000 14.78043 ? 552  LYS   B C   1 
ATOM   3619 O O   . LYS   B 1 197 ? -5.86185  -8.71349  -1.23932  1.000 13.67164 ? 552  LYS   B O   1 
ATOM   3620 C CB  . LYS   B 1 197 ? -8.42887  -7.01697  -2.16348  1.000 18.56607 ? 552  LYS   B CB  1 
ATOM   3621 C CG  . LYS   B 1 197 ? -9.44630  -6.63952  -3.22189  1.000 29.04681 ? 552  LYS   B CG  1 
ATOM   3622 C CD  . LYS   B 1 197 ? -8.93073  -6.84433  -4.63009  1.000 32.58564 ? 552  LYS   B CD  1 
ATOM   3623 C CE  . LYS   B 1 197 ? -9.90635  -6.37940  -5.75717  1.000 18.44283 ? 552  LYS   B CE  1 
ATOM   3624 N NZ  . LYS   B 1 197 ? -9.73629  -4.93791  -6.27279  1.000 27.79905 ? 552  LYS   B NZ  1 
ATOM   3625 N N   . SER   B 1 198 ? -7.34112  -8.53610  0.45052   1.000 13.82769 ? 553  SER   B N   1 
ATOM   3626 C CA  . SER   B 1 198 ? -6.27479  -8.75915  1.42988   1.000 12.96547 ? 553  SER   B CA  1 
ATOM   3627 C C   . SER   B 1 198 ? -5.71385  -10.17713 1.30297   1.000 12.74024 ? 553  SER   B C   1 
ATOM   3628 O O   . SER   B 1 198 ? -4.49166  -10.38594 1.41364   1.000 12.99760 ? 553  SER   B O   1 
ATOM   3629 C CB  . SER   B 1 198 ? -6.78046  -8.51947  2.85263   1.000 16.80045 ? 553  SER   B CB  1 
ATOM   3630 O OG  . SER   B 1 198 ? -7.58976  -7.30718  2.87374   1.000 18.28994 ? 553  SER   B OG  1 
ATOM   3631 N N   . ASP   B 1 199 ? -6.57856  -11.17309 1.10151   1.000 11.66467 ? 554  ASP   B N   1 
ATOM   3632 C CA  . ASP   B 1 199 ? -6.07814  -12.52050 0.85288   1.000 12.47355 ? 554  ASP   B CA  1 
ATOM   3633 C C   . ASP   B 1 199 ? -5.21284  -12.57305 -0.39659  1.000 12.97361 ? 554  ASP   B C   1 
ATOM   3634 O O   . ASP   B 1 199 ? -4.27429  -13.38626 -0.44215  1.000 11.52104 ? 554  ASP   B O   1 
ATOM   3635 C CB  . ASP   B 1 199 ? -7.23880  -13.54462 0.71445   1.000 11.33998 ? 554  ASP   B CB  1 
ATOM   3636 C CG  . ASP   B 1 199 ? -7.89822  -13.92525 2.03837   1.000 13.56261 ? 554  ASP   B CG  1 
ATOM   3637 O OD1 . ASP   B 1 199 ? -7.30399  -13.83015 3.14654   1.000 14.69270 ? 554  ASP   B OD1 1 
ATOM   3638 O OD2 . ASP   B 1 199 ? -9.08323  -14.36409 1.88829   1.000 14.22629 ? 554  ASP   B OD2 1 
ATOM   3639 N N   . VAL   B 1 200 ? -5.50228  -11.74155 -1.43642  1.000 12.21224 ? 555  VAL   B N   1 
ATOM   3640 C CA  . VAL   B 1 200 ? -4.62628  -11.71051 -2.62325  1.000 11.79543 ? 555  VAL   B CA  1 
ATOM   3641 C C   . VAL   B 1 200 ? -3.20987  -11.28576 -2.24179  1.000 11.97739 ? 555  VAL   B C   1 
ATOM   3642 O O   . VAL   B 1 200 ? -2.21788  -11.87288 -2.73629  1.000 12.15848 ? 555  VAL   B O   1 
ATOM   3643 C CB  . VAL   B 1 200 ? -5.22529  -10.78990 -3.69388  1.000 11.75443 ? 555  VAL   B CB  1 
ATOM   3644 C CG1 . VAL   B 1 200 ? -4.21995  -10.54584 -4.85867  1.000 13.74881 ? 555  VAL   B CG1 1 
ATOM   3645 C CG2 . VAL   B 1 200 ? -6.50633  -11.35328 -4.26865  1.000 13.18061 ? 555  VAL   B CG2 1 
ATOM   3646 N N   . TRP   B 1 201 ? -3.07313  -10.28140 -1.38295  1.000 11.93332 ? 556  TRP   B N   1 
ATOM   3647 C CA  . TRP   B 1 201 ? -1.74517  -9.87189  -0.90789  1.000 10.99413 ? 556  TRP   B CA  1 
ATOM   3648 C C   . TRP   B 1 201 ? -1.02704  -11.06213 -0.26990  1.000 10.92843 ? 556  TRP   B C   1 
ATOM   3649 O O   . TRP   B 1 201 ? 0.14399   -11.37422 -0.61433  1.000 11.45857 ? 556  TRP   B O   1 
ATOM   3650 C CB  . TRP   B 1 201 ? -1.88430  -8.71656  0.10234   1.000 11.69382 ? 556  TRP   B CB  1 
ATOM   3651 C CG  . TRP   B 1 201 ? -0.54411  -8.29570  0.62083   1.000 11.23379 ? 556  TRP   B CG  1 
ATOM   3652 C CD1 . TRP   B 1 201 ? 0.24955   -8.97890  1.53285   1.000 12.80491 ? 556  TRP   B CD1 1 
ATOM   3653 C CD2 . TRP   B 1 201 ? 0.14715   -7.07120  0.31969   1.000 11.91070 ? 556  TRP   B CD2 1 
ATOM   3654 N NE1 . TRP   B 1 201 ? 1.43734   -8.27338  1.74460   1.000 13.19388 ? 556  TRP   B NE1 1 
ATOM   3655 C CE2 . TRP   B 1 201 ? 1.39388   -7.11836  1.00172   1.000 10.96467 ? 556  TRP   B CE2 1 
ATOM   3656 C CE3 . TRP   B 1 201 ? -0.13951  -5.96345  -0.51056  1.000 11.86104 ? 556  TRP   B CE3 1 
ATOM   3657 C CZ2 . TRP   B 1 201 ? 2.33095   -6.09509  0.91931   1.000 12.46006 ? 556  TRP   B CZ2 1 
ATOM   3658 C CZ3 . TRP   B 1 201 ? 0.79619   -4.93055  -0.57216  1.000 12.23234 ? 556  TRP   B CZ3 1 
ATOM   3659 C CH2 . TRP   B 1 201 ? 2.00887   -5.02096  0.12564   1.000 11.75662 ? 556  TRP   B CH2 1 
ATOM   3660 N N   . SER   B 1 202 ? -1.72490  -11.76937 0.64723   1.000 10.26271 ? 557  SER   B N   1 
ATOM   3661 C CA  . SER   B 1 202 ? -1.12744  -12.95074 1.28991   1.000 10.14595 ? 557  SER   B CA  1 
ATOM   3662 C C   . SER   B 1 202 ? -0.73548  -13.99170 0.26726   1.000 10.99442 ? 557  SER   B C   1 
ATOM   3663 O O   . SER   B 1 202 ? 0.31879   -14.63253 0.40216   1.000 11.81102 ? 557  SER   B O   1 
ATOM   3664 C CB  . SER   B 1 202 ? -2.10296  -13.59285 2.27528   1.000 13.80629 ? 557  SER   B CB  1 
ATOM   3665 O OG  . SER   B 1 202 ? -2.69249  -12.61276 3.10434   1.000 17.06500 ? 557  SER   B OG  1 
ATOM   3666 N N   . PHE   B 1 203 ? -1.56559  -14.15919 -0.76746  1.000 10.96264 ? 558  PHE   B N   1 
ATOM   3667 C CA  . PHE   B 1 203 ? -1.26014  -15.10889 -1.82210  1.000 11.25959 ? 558  PHE   B CA  1 
ATOM   3668 C C   . PHE   B 1 203 ? 0.06620   -14.75522 -2.52501  1.000 11.03561 ? 558  PHE   B C   1 
ATOM   3669 O O   . PHE   B 1 203 ? 0.84375   -15.65510 -2.89956  1.000 11.36430 ? 558  PHE   B O   1 
ATOM   3670 C CB  . PHE   B 1 203 ? -2.43606  -15.17321 -2.82192  1.000 11.65398 ? 558  PHE   B CB  1 
ATOM   3671 C CG  . PHE   B 1 203 ? -2.18214  -16.13151 -3.95335  1.000 10.96811 ? 558  PHE   B CG  1 
ATOM   3672 C CD1 . PHE   B 1 203 ? -2.23707  -17.51315 -3.71715  1.000 12.59092 ? 558  PHE   B CD1 1 
ATOM   3673 C CD2 . PHE   B 1 203 ? -1.80703  -15.66982 -5.20746  1.000 11.05771 ? 558  PHE   B CD2 1 
ATOM   3674 C CE1 . PHE   B 1 203 ? -2.01510  -18.43276 -4.75112  1.000 13.96996 ? 558  PHE   B CE1 1 
ATOM   3675 C CE2 . PHE   B 1 203 ? -1.54974  -16.57187 -6.22990  1.000 12.09736 ? 558  PHE   B CE2 1 
ATOM   3676 C CZ  . PHE   B 1 203 ? -1.65877  -17.93178 -6.01413  1.000 12.30228 ? 558  PHE   B CZ  1 
ATOM   3677 N N   . GLY   B 1 204 ? 0.34406   -13.46970 -2.69354  1.000 11.29868 ? 559  GLY   B N   1 
ATOM   3678 C CA  . GLY   B 1 204 ? 1.65327   -13.08908 -3.23153  1.000 11.00687 ? 559  GLY   B CA  1 
ATOM   3679 C C   . GLY   B 1 204 ? 2.79522   -13.54519 -2.33736  1.000 10.56662 ? 559  GLY   B C   1 
ATOM   3680 O O   . GLY   B 1 204 ? 3.84637   -13.98750 -2.81143  1.000 11.64118 ? 559  GLY   B O   1 
ATOM   3681 N N   . VAL   B 1 205 ? 2.62806   -13.41260 -1.01867  1.000 10.14126 ? 560  VAL   B N   1 
ATOM   3682 C CA  . VAL   B 1 205 ? 3.66595   -13.89722 -0.11786  1.000 9.66073  ? 560  VAL   B CA  1 
ATOM   3683 C C   . VAL   B 1 205 ? 3.78299   -15.42191 -0.21723  1.000 11.27540 ? 560  VAL   B C   1 
ATOM   3684 O O   . VAL   B 1 205 ? 4.88255   -15.96887 -0.24861  1.000 10.68106 ? 560  VAL   B O   1 
ATOM   3685 C CB  . VAL   B 1 205 ? 3.37171   -13.45857 1.33215   1.000 9.80110  ? 560  VAL   B CB  1 
ATOM   3686 C CG1 . VAL   B 1 205 ? 4.48175   -13.88260 2.25345   1.000 12.34804 ? 560  VAL   B CG1 1 
ATOM   3687 C CG2 . VAL   B 1 205 ? 3.27836   -11.90784 1.37986   1.000 10.64839 ? 560  VAL   B CG2 1 
ATOM   3688 N N   . LEU   B 1 206 ? 2.64961   -16.12414 -0.28148  1.000 10.65829 ? 561  LEU   B N   1 
ATOM   3689 C CA  . LEU   B 1 206 ? 2.64366   -17.56983 -0.48363  1.000 9.72734  ? 561  LEU   B CA  1 
ATOM   3690 C C   . LEU   B 1 206 ? 3.39645   -17.94355 -1.75067  1.000 11.28379 ? 561  LEU   B C   1 
ATOM   3691 O O   . LEU   B 1 206 ? 4.21826   -18.88062 -1.72441  1.000 11.41541 ? 561  LEU   B O   1 
ATOM   3692 C CB  . LEU   B 1 206 ? 1.18839   -18.04901 -0.52810  1.000 11.21505 ? 561  LEU   B CB  1 
ATOM   3693 C CG  . LEU   B 1 206 ? 0.91643   -19.51966 -0.56705  1.000 12.28758 ? 561  LEU   B CG  1 
ATOM   3694 C CD1 . LEU   B 1 206 ? -0.55718  -19.74484 -0.00767  1.000 14.87316 ? 561  LEU   B CD1 1 
ATOM   3695 C CD2 . LEU   B 1 206 ? 1.04278   -20.03338 -1.98145  1.000 16.74367 ? 561  LEU   B CD2 1 
ATOM   3696 N N   . MET   B 1 207 ? 3.12347   -17.23508 -2.84389  1.000 12.35904 ? 562  MET   B N   1 
ATOM   3697 C CA  . MET   B 1 207 ? 3.86647   -17.50157 -4.08461  1.000 12.65576 ? 562  MET   B CA  1 
ATOM   3698 C C   . MET   B 1 207 ? 5.36731   -17.35026 -3.83706  1.000 10.65641 ? 562  MET   B C   1 
ATOM   3699 O O   . MET   B 1 207 ? 6.17349   -18.20529 -4.25706  1.000 12.33171 ? 562  MET   B O   1 
ATOM   3700 C CB  . MET   B 1 207 ? 3.45849   -16.54674 -5.23225  1.000 12.89201 ? 562  MET   B CB  1 
ATOM   3701 C CG  . MET   B 1 207 ? 2.06548   -16.72172 -5.75964  1.000 18.22890 ? 562  MET   B CG  1 
ATOM   3702 S SD  . MET   B 1 207 ? 1.79545   -15.53287 -7.15842  1.000 18.86900 ? 562  MET   B SD  1 
ATOM   3703 C CE  . MET   B 1 207 ? 3.02297   -16.17623 -8.36764  1.000 17.10567 ? 562  MET   B CE  1 
ATOM   3704 N N   . TRP   B 1 208 ? 5.77345   -16.23169 -3.20656  1.000 10.60520 ? 563  TRP   B N   1 
ATOM   3705 C CA  . TRP   B 1 208 ? 7.20090   -16.05300 -2.94309  1.000 12.35670 ? 563  TRP   B CA  1 
ATOM   3706 C C   . TRP   B 1 208 ? 7.74285   -17.22662 -2.13571  1.000 12.63426 ? 563  TRP   B C   1 
ATOM   3707 O O   . TRP   B 1 208 ? 8.82432   -17.78335 -2.44365  1.000 12.03507 ? 563  TRP   B O   1 
ATOM   3708 C CB  . TRP   B 1 208 ? 7.40397   -14.69832 -2.21588  1.000 11.32937 ? 563  TRP   B CB  1 
ATOM   3709 C CG  . TRP   B 1 208 ? 8.86274   -14.36989 -2.02200  1.000 11.16830 ? 563  TRP   B CG  1 
ATOM   3710 C CD1 . TRP   B 1 208 ? 9.65590   -13.59221 -2.85944  1.000 12.57694 ? 563  TRP   B CD1 1 
ATOM   3711 C CD2 . TRP   B 1 208 ? 9.70699   -14.89706 -1.02431  1.000 12.29015 ? 563  TRP   B CD2 1 
ATOM   3712 N NE1 . TRP   B 1 208 ? 10.94823  -13.58633 -2.36601  1.000 14.30294 ? 563  TRP   B NE1 1 
ATOM   3713 C CE2 . TRP   B 1 208 ? 11.02125  -14.38412 -1.26304  1.000 11.78463 ? 563  TRP   B CE2 1 
ATOM   3714 C CE3 . TRP   B 1 208 ? 9.49593   -15.73034 0.08185   1.000 11.21709 ? 563  TRP   B CE3 1 
ATOM   3715 C CZ2 . TRP   B 1 208 ? 12.11636  -14.71969 -0.42064  1.000 12.78339 ? 563  TRP   B CZ2 1 
ATOM   3716 C CZ3 . TRP   B 1 208 ? 10.62615  -16.05880 0.91797   1.000 15.03127 ? 563  TRP   B CZ3 1 
ATOM   3717 C CH2 . TRP   B 1 208 ? 11.89222  -15.55555 0.62877   1.000 16.12561 ? 563  TRP   B CH2 1 
ATOM   3718 N N   . GLU   B 1 209 ? 7.00155   -17.66799 -1.10794  1.000 10.11162 ? 564  GLU   B N   1 
ATOM   3719 C CA  . GLU   B 1 209 ? 7.45035   -18.80286 -0.31706  1.000 10.65753 ? 564  GLU   B CA  1 
ATOM   3720 C C   . GLU   B 1 209 ? 7.60716   -20.05997 -1.16066  1.000 11.88546 ? 564  GLU   B C   1 
ATOM   3721 O O   . GLU   B 1 209 ? 8.58489   -20.80029 -1.00741  1.000 12.53792 ? 564  GLU   B O   1 
ATOM   3722 C CB  . GLU   B 1 209 ? 6.43336   -19.10013 0.77855   1.000 11.17674 ? 564  GLU   B CB  1 
ATOM   3723 C CG  . GLU   B 1 209 ? 6.31777   -18.07405 1.88787   1.000 12.58400 ? 564  GLU   B CG  1 
ATOM   3724 C CD  . GLU   B 1 209 ? 5.26864   -18.57444 2.84310   1.000 12.57304 ? 564  GLU   B CD  1 
ATOM   3725 O OE1 . GLU   B 1 209 ? 4.03666   -18.36969 2.60838   1.000 13.05964 ? 564  GLU   B OE1 1 
ATOM   3726 O OE2 . GLU   B 1 209 ? 5.64198   -19.22890 3.83797   1.000 14.98151 ? 564  GLU   B OE2 1 
ATOM   3727 N N   . ALA   B 1 210 ? 6.62853   -20.34267 -2.01530  1.000 11.35867 ? 565  ALA   B N   1 
ATOM   3728 C CA  . ALA   B 1 210 ? 6.66887   -21.55354 -2.83104  1.000 12.36930 ? 565  ALA   B CA  1 
ATOM   3729 C C   . ALA   B 1 210 ? 7.84775   -21.54176 -3.79720  1.000 14.26005 ? 565  ALA   B C   1 
ATOM   3730 O O   . ALA   B 1 210 ? 8.59381   -22.53052 -3.89405  1.000 13.72103 ? 565  ALA   B O   1 
ATOM   3731 C CB  . ALA   B 1 210 ? 5.36352   -21.67131 -3.60361  1.000 13.96372 ? 565  ALA   B CB  1 
ATOM   3732 N N   . PHE   B 1 211 ? 8.03850   -20.42041 -4.49178  1.000 11.69725 ? 566  PHE   B N   1 
ATOM   3733 C CA  . PHE   B 1 211 ? 9.16298   -20.34252 -5.44470  1.000 12.85047 ? 566  PHE   B CA  1 
ATOM   3734 C C   . PHE   B 1 211 ? 10.50988  -20.27221 -4.71851  1.000 14.59237 ? 566  PHE   B C   1 
ATOM   3735 O O   . PHE   B 1 211 ? 11.54175  -20.51681 -5.36364  1.000 17.11442 ? 566  PHE   B O   1 
ATOM   3736 C CB  . PHE   B 1 211 ? 8.95940   -19.16538 -6.40166  1.000 12.99289 ? 566  PHE   B CB  1 
ATOM   3737 C CG  . PHE   B 1 211 ? 7.92659   -19.45459 -7.45685  1.000 13.32945 ? 566  PHE   B CG  1 
ATOM   3738 C CD1 . PHE   B 1 211 ? 8.25351   -20.22825 -8.56099  1.000 16.26856 ? 566  PHE   B CD1 1 
ATOM   3739 C CD2 . PHE   B 1 211 ? 6.63599   -18.96633 -7.35613  1.000 14.97301 ? 566  PHE   B CD2 1 
ATOM   3740 C CE1 . PHE   B 1 211 ? 7.29695   -20.51966 -9.53394  1.000 17.92382 ? 566  PHE   B CE1 1 
ATOM   3741 C CE2 . PHE   B 1 211 ? 5.67991   -19.25205 -8.32318  1.000 15.04000 ? 566  PHE   B CE2 1 
ATOM   3742 C CZ  . PHE   B 1 211 ? 6.01452   -20.04790 -9.41930  1.000 18.82504 ? 566  PHE   B CZ  1 
ATOM   3743 N N   . SER   B 1 212 ? 10.52288  -19.98694 -3.41334  1.000 12.77041 ? 567  SER   B N   1 
ATOM   3744 C CA  . SER   B 1 212 ? 11.69935  -20.05300 -2.55578  1.000 12.58340 ? 567  SER   B CA  1 
ATOM   3745 C C   . SER   B 1 212 ? 11.83098  -21.38601 -1.82179  1.000 12.69113 ? 567  SER   B C   1 
ATOM   3746 O O   . SER   B 1 212 ? 12.59946  -21.49421 -0.86429  1.000 14.41778 ? 567  SER   B O   1 
ATOM   3747 C CB  . SER   B 1 212 ? 11.64864  -18.89306 -1.53721  1.000 11.43022 ? 567  SER   B CB  1 
ATOM   3748 O OG  . SER   B 1 212 ? 11.57890  -17.66053 -2.21567  1.000 13.22459 ? 567  SER   B OG  1 
ATOM   3749 N N   . TYR   B 1 213 ? 11.06953  -22.41115 -2.21608  1.000 13.10489 ? 568  TYR   B N   1 
ATOM   3750 C CA  . TYR   B 1 213 ? 11.16061  -23.74821 -1.62182  1.000 13.80576 ? 568  TYR   B CA  1 
ATOM   3751 C C   . TYR   B 1 213 ? 10.98489  -23.73147 -0.11658  1.000 15.79187 ? 568  TYR   B C   1 
ATOM   3752 O O   . TYR   B 1 213 ? 11.65174  -24.43904 0.64665   1.000 18.79554 ? 568  TYR   B O   1 
ATOM   3753 C CB  . TYR   B 1 213 ? 12.47055  -24.46499 -2.02553  1.000 15.30071 ? 568  TYR   B CB  1 
ATOM   3754 C CG  . TYR   B 1 213 ? 12.45982  -24.79969 -3.49748  1.000 16.23285 ? 568  TYR   B CG  1 
ATOM   3755 C CD1 . TYR   B 1 213 ? 12.77964  -23.84202 -4.44910  1.000 16.75895 ? 568  TYR   B CD1 1 
ATOM   3756 C CD2 . TYR   B 1 213 ? 12.08978  -26.07566 -3.96105  1.000 18.71259 ? 568  TYR   B CD2 1 
ATOM   3757 C CE1 . TYR   B 1 213 ? 12.73852  -24.11955 -5.79038  1.000 16.47972 ? 568  TYR   B CE1 1 
ATOM   3758 C CE2 . TYR   B 1 213 ? 12.05213  -26.36473 -5.32873  1.000 19.69645 ? 568  TYR   B CE2 1 
ATOM   3759 C CZ  . TYR   B 1 213 ? 12.38234  -25.39141 -6.23057  1.000 18.58635 ? 568  TYR   B CZ  1 
ATOM   3760 O OH  . TYR   B 1 213 ? 12.36202  -25.65730 -7.57517  1.000 26.23837 ? 568  TYR   B OH  1 
ATOM   3761 N N   . GLY   B 1 214 ? 10.01766  -22.91947 0.32368   1.000 13.28313 ? 569  GLY   B N   1 
ATOM   3762 C CA  . GLY   B 1 214 ? 9.67222   -22.93210 1.71999   1.000 15.65476 ? 569  GLY   B CA  1 
ATOM   3763 C C   . GLY   B 1 214 ? 10.50275  -22.08052 2.63712   1.000 15.49783 ? 569  GLY   B C   1 
ATOM   3764 O O   . GLY   B 1 214 ? 10.40494  -22.25031 3.86489   1.000 20.38044 ? 569  GLY   B O   1 
ATOM   3765 N N   . GLN   B 1 215 ? 11.31837  -21.18754 2.10340   1.000 16.27184 ? 570  GLN   B N   1 
ATOM   3766 C CA  . GLN   B 1 215 ? 11.99104  -20.18783 2.93794   1.000 17.85694 ? 570  GLN   B CA  1 
ATOM   3767 C C   . GLN   B 1 215 ? 10.94526  -19.28600 3.57324   1.000 16.85638 ? 570  GLN   B C   1 
ATOM   3768 O O   . GLN   B 1 215 ? 9.90804   -19.00287 2.98438   1.000 17.23293 ? 570  GLN   B O   1 
ATOM   3769 C CB  . GLN   B 1 215 ? 12.96044  -19.34048 2.08873   1.000 20.75558 ? 570  GLN   B CB  1 
ATOM   3770 C CG  . GLN   B 1 215 ? 13.74156  -18.16836 2.82244   1.000 28.68358 ? 570  GLN   B CG  1 
ATOM   3771 C CD  . GLN   B 1 215 ? 14.66756  -17.26539 1.91124   1.000 42.12493 ? 570  GLN   B CD  1 
ATOM   3772 O OE1 . GLN   B 1 215 ? 14.94874  -16.08426 2.24694   1.000 31.20764 ? 570  GLN   B OE1 1 
ATOM   3773 N NE2 . GLN   B 1 215 ? 15.14845  -17.81977 0.78862   1.000 31.79264 ? 570  GLN   B NE2 1 
ATOM   3774 N N   . LYS   B 1 216 ? 11.23877  -18.80800 4.78299   1.000 17.27354 ? 571  LYS   B N   1 
ATOM   3775 C CA  . LYS   B 1 216 ? 10.37023  -17.83220 5.44270   1.000 16.05655 ? 571  LYS   B CA  1 
ATOM   3776 C C   . LYS   B 1 216 ? 10.47932  -16.48448 4.72748   1.000 15.67692 ? 571  LYS   B C   1 
ATOM   3777 O O   . LYS   B 1 216 ? 11.57819  -16.08727 4.29929   1.000 14.92102 ? 571  LYS   B O   1 
ATOM   3778 C CB  . LYS   B 1 216 ? 10.77207  -17.65008 6.90314   1.000 20.91364 ? 571  LYS   B CB  1 
ATOM   3779 C CG  . LYS   B 1 216 ? 10.77959  -18.92674 7.70792   1.000 30.81984 ? 571  LYS   B CG  1 
ATOM   3780 C CD  . LYS   B 1 216 ? 11.35443  -18.68673 9.11825   1.000 38.00735 ? 571  LYS   B CD  1 
ATOM   3781 C CE  . LYS   B 1 216 ? 12.60400  -17.79921 9.08253   1.000 45.95009 ? 571  LYS   B CE  1 
ATOM   3782 N NZ  . LYS   B 1 216 ? 13.76949  -18.47184 8.42449   1.000 53.03067 ? 571  LYS   B NZ  1 
ATOM   3783 N N   . PRO   B 1 217 ? 9.38174   -15.76216 4.56480   1.000 14.45703 ? 572  PRO   B N   1 
ATOM   3784 C CA  . PRO   B 1 217 ? 9.46257   -14.42211 3.95871   1.000 12.53812 ? 572  PRO   B CA  1 
ATOM   3785 C C   . PRO   B 1 217 ? 10.03740  -13.41060 4.95364   1.000 13.98717 ? 572  PRO   B C   1 
ATOM   3786 O O   . PRO   B 1 217 ? 9.92464   -13.56730 6.18626   1.000 15.00194 ? 572  PRO   B O   1 
ATOM   3787 C CB  . PRO   B 1 217 ? 7.99764   -14.09174 3.63198   1.000 14.91223 ? 572  PRO   B CB  1 
ATOM   3788 C CG  . PRO   B 1 217 ? 7.17129   -14.88283 4.70983   1.000 15.88970 ? 572  PRO   B CG  1 
ATOM   3789 C CD  . PRO   B 1 217 ? 8.02694   -16.10317 5.06854   1.000 15.86262 ? 572  PRO   B CD  1 
ATOM   3790 N N   . TYR   B 1 218 ? 10.59553  -12.32832 4.39883   1.000 13.41002 ? 573  TYR   B N   1 
ATOM   3791 C CA  . TYR   B 1 218 ? 11.12649  -11.19895 5.18752   1.000 13.28770 ? 573  TYR   B CA  1 
ATOM   3792 C C   . TYR   B 1 218 ? 12.07827  -11.72650 6.25579   1.000 14.00170 ? 573  TYR   B C   1 
ATOM   3793 O O   . TYR   B 1 218 ? 12.00331  -11.38887 7.44651   1.000 14.51258 ? 573  TYR   B O   1 
ATOM   3794 C CB  . TYR   B 1 218 ? 10.01608  -10.33960 5.81311   1.000 12.50692 ? 573  TYR   B CB  1 
ATOM   3795 C CG  . TYR   B 1 218 ? 9.02997   -9.83185  4.82340   1.000 10.69796 ? 573  TYR   B CG  1 
ATOM   3796 C CD1 . TYR   B 1 218 ? 9.29672   -8.72219  3.99124   1.000 11.66639 ? 573  TYR   B CD1 1 
ATOM   3797 C CD2 . TYR   B 1 218 ? 7.81375   -10.45714 4.71840   1.000 11.11196 ? 573  TYR   B CD2 1 
ATOM   3798 C CE1 . TYR   B 1 218 ? 8.38477   -8.26678  3.04944   1.000 11.11382 ? 573  TYR   B CE1 1 
ATOM   3799 C CE2 . TYR   B 1 218 ? 6.90141   -10.02552 3.79150   1.000 11.43177 ? 573  TYR   B CE2 1 
ATOM   3800 C CZ  . TYR   B 1 218 ? 7.18547   -8.93351  2.95012   1.000 10.72371 ? 573  TYR   B CZ  1 
ATOM   3801 O OH  . TYR   B 1 218 ? 6.24023   -8.46450  2.07860   1.000 12.88289 ? 573  TYR   B OH  1 
ATOM   3802 N N   . ARG   B 1 219 ? 12.98704  -12.59406 5.83171   1.000 15.22512 ? 574  ARG   B N   1 
ATOM   3803 C CA  . ARG   B 1 219 ? 13.89799  -13.25092 6.75557   1.000 18.58848 ? 574  ARG   B CA  1 
ATOM   3804 C C   . ARG   B 1 219 ? 14.67583  -12.24735 7.59330   1.000 14.69084 ? 574  ARG   B C   1 
ATOM   3805 O O   . ARG   B 1 219 ? 15.18467  -11.25296 7.08641   1.000 14.06498 ? 574  ARG   B O   1 
ATOM   3806 C CB  . ARG   B 1 219 ? 14.84931  -14.12615 5.92962   1.000 24.75754 ? 574  ARG   B CB  1 
ATOM   3807 C CG  . ARG   B 1 219 ? 16.19316  -14.39607 6.46102   1.000 29.62516 ? 574  ARG   B CG  1 
ATOM   3808 C CD  . ARG   B 1 219 ? 16.81994  -15.52572 5.63491   1.000 23.09844 ? 574  ARG   B CD  1 
ATOM   3809 N NE  . ARG   B 1 219 ? 17.69798  -15.06445 4.56993   1.000 16.98573 ? 574  ARG   B NE  1 
ATOM   3810 C CZ  . ARG   B 1 219 ? 18.25535  -15.86172 3.66408   1.000 23.06109 ? 574  ARG   B CZ  1 
ATOM   3811 N NH1 . ARG   B 1 219 ? 17.95264  -17.14940 3.59140   1.000 22.42257 ? 574  ARG   B NH1 1 
ATOM   3812 N NH2 . ARG   B 1 219 ? 19.11962  -15.35010 2.79458   1.000 24.30602 ? 574  ARG   B NH2 1 
ATOM   3813 N N   . GLY   B 1 220 ? 14.76300  -12.52273 8.88630   1.000 16.29590 ? 575  GLY   B N   1 
ATOM   3814 C CA  . GLY   B 1 220 ? 15.53815  -11.69893 9.79132   1.000 16.84976 ? 575  GLY   B CA  1 
ATOM   3815 C C   . GLY   B 1 220 ? 14.88594  -10.41681 10.24273  1.000 21.59134 ? 575  GLY   B C   1 
ATOM   3816 O O   . GLY   B 1 220 ? 15.52080  -9.64324  10.98247  1.000 21.92822 ? 575  GLY   B O   1 
ATOM   3817 N N   . MET   B 1 221 ? 13.65313  -10.15640 9.82323   1.000 16.49785 ? 576  MET   B N   1 
ATOM   3818 C CA  . MET   B 1 221 ? 13.01740  -8.85985  10.00884  1.000 16.36446 ? 576  MET   B CA  1 
ATOM   3819 C C   . MET   B 1 221 ? 11.90053  -8.93460  11.03581  1.000 16.90884 ? 576  MET   B C   1 
ATOM   3820 O O   . MET   B 1 221 ? 11.14669  -9.91080  11.10129  1.000 18.79555 ? 576  MET   B O   1 
ATOM   3821 C CB  . MET   B 1 221 ? 12.41907  -8.32168  8.72535   1.000 14.28082 ? 576  MET   B CB  1 
ATOM   3822 C CG  . MET   B 1 221 ? 13.47393  -8.04063  7.66307   1.000 15.69447 ? 576  MET   B CG  1 
ATOM   3823 S SD  . MET   B 1 221 ? 12.81319  -7.57859  6.06790   1.000 16.92080 ? 576  MET   B SD  1 
ATOM   3824 C CE  . MET   B 1 221 ? 12.06264  -5.99871  6.50933   1.000 17.78414 ? 576  MET   B CE  1 
ATOM   3825 N N   . LYS   B 1 222 ? 11.80415  -7.87308  11.83801  1.000 20.09540 ? 577  LYS   B N   1 
ATOM   3826 C CA  . LYS   B 1 222 ? 10.67402  -7.73372  12.72894  1.000 22.52640 ? 577  LYS   B CA  1 
ATOM   3827 C C   . LYS   B 1 222 ? 9.46199   -7.23859  11.94828  1.000 18.91556 ? 577  LYS   B C   1 
ATOM   3828 O O   . LYS   B 1 222 ? 9.59416   -6.58056  10.90516  1.000 18.90134 ? 577  LYS   B O   1 
ATOM   3829 C CB  . LYS   B 1 222 ? 10.98554  -6.73057  13.84333  1.000 28.90773 ? 577  LYS   B CB  1 
ATOM   3830 C CG  . LYS   B 1 222 ? 11.99967  -7.19143  14.84117  1.000 32.57108 ? 577  LYS   B CG  1 
ATOM   3831 C CD  . LYS   B 1 222 ? 12.39907  -6.02627  15.74575  1.000 39.84754 ? 577  LYS   B CD  1 
ATOM   3832 C CE  . LYS   B 1 222 ? 13.16945  -6.53845  16.93913  1.000 39.72873 ? 577  LYS   B CE  1 
ATOM   3833 N NZ  . LYS   B 1 222 ? 13.79875  -5.42641  17.71431  1.000 55.78799 ? 577  LYS   B NZ  1 
ATOM   3834 N N   . GLY   B 1 223 ? 8.28027   -7.49006  12.51453  1.000 22.49584 ? 578  GLY   B N   1 
ATOM   3835 C CA  . GLY   B 1 223 ? 7.06092   -6.97834  11.90726  1.000 25.75169 ? 578  GLY   B CA  1 
ATOM   3836 C C   . GLY   B 1 223 ? 7.12384   -5.49113  11.60824  1.000 22.25087 ? 578  GLY   B C   1 
ATOM   3837 O O   . GLY   B 1 223 ? 6.72673   -5.04958  10.53515  1.000 19.65683 ? 578  GLY   B O   1 
ATOM   3838 N N   . SER   B 1 224 ? 7.64082   -4.68248  12.55209  1.000 22.76981 ? 579  SER   B N   1 
ATOM   3839 C CA  . SER   B 1 224 ? 7.67973   -3.24948  12.29880  1.000 23.84898 ? 579  SER   B CA  1 
ATOM   3840 C C   . SER   B 1 224 ? 8.62785   -2.92571  11.16698  1.000 20.64904 ? 579  SER   B C   1 
ATOM   3841 O O   . SER   B 1 224 ? 8.40662   -1.96891  10.41504  1.000 22.72809 ? 579  SER   B O   1 
ATOM   3842 C CB  . SER   B 1 224 ? 8.10429   -2.47497  13.55242  1.000 29.48545 ? 579  SER   B CB  1 
ATOM   3843 O OG  . SER   B 1 224 ? 9.36525   -2.93208  14.02303  1.000 33.38334 ? 579  SER   B OG  1 
ATOM   3844 N N   . GLU   B 1 225 ? 9.65972   -3.76992  10.98449  1.000 19.53467 ? 580  GLU   B N   1 
ATOM   3845 C CA  . GLU   B 1 225 ? 10.60793  -3.53289  9.92565   1.000 18.65091 ? 580  GLU   B CA  1 
ATOM   3846 C C   . GLU   B 1 225 ? 9.97680   -3.89215  8.57812   1.000 15.56935 ? 580  GLU   B C   1 
ATOM   3847 O O   . GLU   B 1 225 ? 10.27239  -3.23224  7.57050   1.000 17.81367 ? 580  GLU   B O   1 
ATOM   3848 C CB  . GLU   B 1 225 ? 11.88208  -4.33890  10.17601  1.000 20.18090 ? 580  GLU   B CB  1 
ATOM   3849 C CG  . GLU   B 1 225 ? 12.71839  -3.73000  11.31827  1.000 22.34485 ? 580  GLU   B CG  1 
ATOM   3850 C CD  . GLU   B 1 225 ? 13.85036  -4.62632  11.78750  1.000 29.81922 ? 580  GLU   B CD  1 
ATOM   3851 O OE1 . GLU   B 1 225 ? 13.76473  -5.87761  11.70437  1.000 24.98879 ? 580  GLU   B OE1 1 
ATOM   3852 O OE2 . GLU   B 1 225 ? 14.84363  -4.05241  12.29028  1.000 31.18381 ? 580  GLU   B OE2 1 
ATOM   3853 N N   . VAL   B 1 226 ? 9.09166   -4.89585  8.57674   1.000 17.02958 ? 581  VAL   B N   1 
ATOM   3854 C CA  . VAL   B 1 226 ? 8.35675   -5.23898  7.36312   1.000 16.94850 ? 581  VAL   B CA  1 
ATOM   3855 C C   . VAL   B 1 226 ? 7.44211   -4.09003  6.96245   1.000 17.68423 ? 581  VAL   B C   1 
ATOM   3856 O O   . VAL   B 1 226 ? 7.39539   -3.67696  5.79698   1.000 16.31521 ? 581  VAL   B O   1 
ATOM   3857 C CB  . VAL   B 1 226 ? 7.56395   -6.53470  7.56670   1.000 13.39427 ? 581  VAL   B CB  1 
ATOM   3858 C CG1 . VAL   B 1 226 ? 6.67264   -6.82257  6.33253   1.000 15.27153 ? 581  VAL   B CG1 1 
ATOM   3859 C CG2 . VAL   B 1 226 ? 8.51490   -7.65412  7.74035   1.000 19.39899 ? 581  VAL   B CG2 1 
ATOM   3860 N N   . THR   B 1 227 ? 6.67465   -3.56397  7.93720   1.000 17.11632 ? 582  THR   B N   1 
ATOM   3861 C CA  . THR   B 1 227 ? 5.83282   -2.40262  7.66558   1.000 21.59315 ? 582  THR   B CA  1 
ATOM   3862 C C   . THR   B 1 227 ? 6.63384   -1.23814  7.10545   1.000 19.73343 ? 582  THR   B C   1 
ATOM   3863 O O   . THR   B 1 227 ? 6.22718   -0.60043  6.12180   1.000 21.90803 ? 582  THR   B O   1 
ATOM   3864 C CB  . THR   B 1 227 ? 5.11388   -2.01298  8.96880   1.000 21.14009 ? 582  THR   B CB  1 
ATOM   3865 O OG1 . THR   B 1 227 ? 4.26450   -3.09349  9.35486   1.000 27.99967 ? 582  THR   B OG1 1 
ATOM   3866 C CG2 . THR   B 1 227 ? 4.28615   -0.72226  8.78998   1.000 33.11508 ? 582  THR   B CG2 1 
ATOM   3867 N N   . ALA   B 1 228 ? 7.79082   -0.96205  7.68899   1.000 20.02322 ? 583  ALA   B N   1 
ATOM   3868 C CA  . ALA   B 1 228 ? 8.60290   0.13878   7.19269   1.000 22.41980 ? 583  ALA   B CA  1 
ATOM   3869 C C   . ALA   B 1 228 ? 9.11410   -0.12452  5.78194   1.000 21.55952 ? 583  ALA   B C   1 
ATOM   3870 O O   . ALA   B 1 228 ? 9.08416   0.76634   4.94071   1.000 20.83754 ? 583  ALA   B O   1 
ATOM   3871 C CB  . ALA   B 1 228 ? 9.75295   0.40096   8.16182   1.000 28.03961 ? 583  ALA   B CB  1 
ATOM   3872 N N   . MET   B 1 229 ? 9.52599   -1.35635  5.48156   1.000 19.00304 ? 584  MET   B N   1 
ATOM   3873 C CA  . MET   B 1 229 ? 9.98932   -1.68751  4.14561   1.000 16.82125 ? 584  MET   B CA  1 
ATOM   3874 C C   . MET   B 1 229 ? 8.88370   -1.48415  3.12375   1.000 16.16559 ? 584  MET   B C   1 
ATOM   3875 O O   . MET   B 1 229 ? 9.10164   -0.91585  2.05811   1.000 16.29630 ? 584  MET   B O   1 
ATOM   3876 C CB  . MET   B 1 229 ? 10.44400  -3.14807  4.12470   1.000 16.96860 ? 584  MET   B CB  1 
ATOM   3877 C CG  . MET   B 1 229 ? 10.73676  -3.69718  2.74716   1.000 17.61183 ? 584  MET   B CG  1 
ATOM   3878 S SD  . MET   B 1 229 ? 11.16323  -5.44497  2.90804   1.000 17.69803 ? 584  MET   B SD  1 
ATOM   3879 C CE  . MET   B 1 229 ? 11.51797  -5.71375  1.19648   1.000 21.00074 ? 584  MET   B CE  1 
ATOM   3880 N N   . LEU   B 1 230 ? 7.69947   -2.00175  3.41596   1.000 17.69194 ? 585  LEU   B N   1 
ATOM   3881 C CA  . LEU   B 1 230 ? 6.60191   -1.91593  2.45448   1.000 15.16435 ? 585  LEU   B CA  1 
ATOM   3882 C C   . LEU   B 1 230 ? 6.15655   -0.48142  2.27959   1.000 17.43908 ? 585  LEU   B C   1 
ATOM   3883 O O   . LEU   B 1 230 ? 5.77892   -0.08451  1.17376   1.000 16.97619 ? 585  LEU   B O   1 
ATOM   3884 C CB  . LEU   B 1 230 ? 5.41424   -2.77822  2.91618   1.000 18.89142 ? 585  LEU   B CB  1 
ATOM   3885 C CG  . LEU   B 1 230 ? 5.73648   -4.26386  3.00612   1.000 16.79865 ? 585  LEU   B CG  1 
ATOM   3886 C CD1 . LEU   B 1 230 ? 4.56954   -4.95511  3.74109   1.000 18.69034 ? 585  LEU   B CD1 1 
ATOM   3887 C CD2 . LEU   B 1 230 ? 5.92772   -4.84480  1.63240   1.000 16.11819 ? 585  LEU   B CD2 1 
ATOM   3888 N N   . GLU   B 1 231 ? 6.26236   0.32705   3.35839   1.000 18.88914 ? 586  GLU   B N   1 
ATOM   3889 C CA  . GLU   B 1 231 ? 5.82573   1.71106   3.24865   1.000 22.20332 ? 586  GLU   B CA  1 
ATOM   3890 C C   . GLU   B 1 231 ? 6.78354   2.54440   2.40739   1.000 21.15736 ? 586  GLU   B C   1 
ATOM   3891 O O   . GLU   B 1 231 ? 6.37240   3.57501   1.85478   1.000 27.08159 ? 586  GLU   B O   1 
ATOM   3892 C CB  . GLU   B 1 231 ? 5.67852   2.30490   4.65050   1.000 27.50249 ? 586  GLU   B CB  1 
ATOM   3893 C CG  . GLU   B 1 231 ? 4.59981   3.33113   4.73080   1.000 35.51470 ? 586  GLU   B CG  1 
ATOM   3894 C CD  . GLU   B 1 231 ? 4.19717   3.60175   6.16619   1.000 33.11291 ? 586  GLU   B CD  1 
ATOM   3895 O OE1 . GLU   B 1 231 ? 3.40637   2.78811   6.73678   1.000 31.29140 ? 586  GLU   B OE1 1 
ATOM   3896 O OE2 . GLU   B 1 231 ? 4.69055   4.62022   6.69935   1.000 45.10922 ? 586  GLU   B OE2 1 
ATOM   3897 N N   . LYS   B 1 232 ? 8.05666   2.15053   2.33504   1.000 19.59070 ? 587  LYS   B N   1 
ATOM   3898 C CA  . LYS   B 1 232 ? 9.06481   2.68889   1.43539   1.000 19.48753 ? 587  LYS   B CA  1 
ATOM   3899 C C   . LYS   B 1 232 ? 8.82518   2.26625   -0.02276  1.000 20.71936 ? 587  LYS   B C   1 
ATOM   3900 O O   . LYS   B 1 232 ? 9.58791   2.63746   -0.91971  1.000 25.90303 ? 587  LYS   B O   1 
ATOM   3901 C CB  . LYS   B 1 232 ? 10.45449  2.19668   1.88895   1.000 21.59588 ? 587  LYS   B CB  1 
ATOM   3902 C CG  . LYS   B 1 232 ? 11.03626  2.84130   3.15789   1.000 27.99480 ? 587  LYS   B CG  1 
ATOM   3903 C CD  . LYS   B 1 232 ? 12.54595  2.61382   3.18634   1.000 35.50068 ? 587  LYS   B CD  1 
ATOM   3904 C CE  . LYS   B 1 232 ? 12.94073  1.51273   4.14445   1.000 40.65805 ? 587  LYS   B CE  1 
ATOM   3905 N NZ  . LYS   B 1 232 ? 13.00726  1.99356   5.55698   1.000 45.91856 ? 587  LYS   B NZ  1 
ATOM   3906 N N   . GLY   B 1 233 ? 7.85237   1.40707   -0.27534  1.000 14.38357 ? 588  GLY   B N   1 
ATOM   3907 C CA  . GLY   B 1 233 ? 7.63620   0.90773   -1.61898  1.000 14.64865 ? 588  GLY   B CA  1 
ATOM   3908 C C   . GLY   B 1 233 ? 8.49158   -0.30416  -1.96996  1.000 17.06138 ? 588  GLY   B C   1 
ATOM   3909 O O   . GLY   B 1 233 ? 8.43016   -0.79140  -3.10674  1.000 16.49673 ? 588  GLY   B O   1 
ATOM   3910 N N   . GLU   B 1 234 ? 9.21047   -0.84905  -1.02332  1.000 13.53683 ? 589  GLU   B N   1 
ATOM   3911 C CA  . GLU   B 1 234 ? 10.12515  -1.94871  -1.32712  1.000 16.09740 ? 589  GLU   B CA  1 
ATOM   3912 C C   . GLU   B 1 234 ? 9.37773   -3.26980  -1.20361  1.000 14.71188 ? 589  GLU   B C   1 
ATOM   3913 O O   . GLU   B 1 234 ? 8.43299   -3.38730  -0.43450  1.000 14.03028 ? 589  GLU   B O   1 
ATOM   3914 C CB  . GLU   B 1 234 ? 11.31838  -1.92300  -0.38474  1.000 16.81804 ? 589  GLU   B CB  1 
ATOM   3915 C CG  . GLU   B 1 234 ? 12.38092  -0.86564  -0.75496  1.000 21.02756 ? 589  GLU   B CG  1 
ATOM   3916 C CD  . GLU   B 1 234 ? 13.41667  -0.73718  0.38542   1.000 28.71690 ? 589  GLU   B CD  1 
ATOM   3917 O OE1 . GLU   B 1 234 ? 13.46733  -1.60433  1.29626   1.000 32.05016 ? 589  GLU   B OE1 1 
ATOM   3918 O OE2 . GLU   B 1 234 ? 14.15781  0.26068   0.39961   1.000 43.27803 ? 589  GLU   B OE2 1 
ATOM   3919 N N   . ARG   B 1 235 ? 9.82798   -4.25473  -1.97022  1.000 12.68204 ? 590  ARG   B N   1 
ATOM   3920 C CA  . ARG   B 1 235 ? 9.24983   -5.59599  -1.98209  1.000 10.69957 ? 590  ARG   B CA  1 
ATOM   3921 C C   . ARG   B 1 235 ? 10.36810  -6.61977  -2.01854  1.000 15.65477 ? 590  ARG   B C   1 
ATOM   3922 O O   . ARG   B 1 235 ? 11.48348  -6.34652  -2.51225  1.000 16.10737 ? 590  ARG   B O   1 
ATOM   3923 C CB  . ARG   B 1 235 ? 8.36227   -5.76117  -3.21849  1.000 13.41080 ? 590  ARG   B CB  1 
ATOM   3924 C CG  . ARG   B 1 235 ? 7.14070   -4.72664  -3.29981  1.000 13.88963 ? 590  ARG   B CG  1 
ATOM   3925 C CD  . ARG   B 1 235 ? 6.09048   -4.98546  -2.19751  1.000 12.05974 ? 590  ARG   B CD  1 
ATOM   3926 N NE  . ARG   B 1 235 ? 4.91104   -4.11901  -2.38774  1.000 13.83833 ? 590  ARG   B NE  1 
ATOM   3927 C CZ  . ARG   B 1 235 ? 4.77689   -2.91886  -1.83065  1.000 13.41401 ? 590  ARG   B CZ  1 
ATOM   3928 N NH1 . ARG   B 1 235 ? 5.73450   -2.38166  -1.06547  1.000 12.96711 ? 590  ARG   B NH1 1 
ATOM   3929 N NH2 . ARG   B 1 235 ? 3.64677   -2.23438  -2.02587  1.000 14.34798 ? 590  ARG   B NH2 1 
ATOM   3930 N N   . MET   B 1 236 ? 10.05754  -7.81428  -1.53546  1.000 13.52112 ? 591  MET   B N   1 
ATOM   3931 C CA  . MET   B 1 236 ? 11.05062  -8.89457  -1.60897  1.000 14.76198 ? 591  MET   B CA  1 
ATOM   3932 C C   . MET   B 1 236 ? 11.53518  -9.11432  -3.03559  1.000 15.17944 ? 591  MET   B C   1 
ATOM   3933 O O   . MET   B 1 236 ? 10.76711  -8.99908  -3.99549  1.000 15.43825 ? 591  MET   B O   1 
ATOM   3934 C CB  . MET   B 1 236 ? 10.42199  -10.19956 -1.11189  1.000 13.19503 ? 591  MET   B CB  1 
ATOM   3935 C CG  . MET   B 1 236 ? 10.18940  -10.17055 0.39384   1.000 13.53518 ? 591  MET   B CG  1 
ATOM   3936 S SD  . MET   B 1 236 ? 9.70627   -11.80258 1.07706   1.000 16.15552 ? 591  MET   B SD  1 
ATOM   3937 C CE  . MET   B 1 236 ? 8.06772   -11.85268 0.51167   1.000 16.88607 ? 591  MET   B CE  1 
ATOM   3938 N N   . GLY   B 1 237 ? 12.80304  -9.53210  -3.13769  1.000 17.27300 ? 592  GLY   B N   1 
ATOM   3939 C CA  . GLY   B 1 237 ? 13.38858  -9.84433  -4.42860  1.000 18.25527 ? 592  GLY   B CA  1 
ATOM   3940 C C   . GLY   B 1 237 ? 12.85050  -11.11774 -5.07270  1.000 17.58869 ? 592  GLY   B C   1 
ATOM   3941 O O   . GLY   B 1 237 ? 12.16297  -11.94888 -4.47229  1.000 17.47255 ? 592  GLY   B O   1 
ATOM   3942 N N   . CYS   B 1 238 ? 13.21150  -11.30158 -6.33211  1.000 16.61781 ? 593  CYS   B N   1 
ATOM   3943 C CA  . CYS   B 1 238 ? 12.76204  -12.48073 -7.08465  1.000 15.98061 ? 593  CYS   B CA  1 
ATOM   3944 C C   . CYS   B 1 238 ? 13.51962  -13.73702 -6.66935  1.000 16.54195 ? 593  CYS   B C   1 
ATOM   3945 O O   . CYS   B 1 238 ? 14.75697  -13.70535 -6.63521  1.000 18.75171 ? 593  CYS   B O   1 
ATOM   3946 C CB  . CYS   B 1 238 ? 13.00220  -12.23073 -8.56029  1.000 17.30600 ? 593  CYS   B CB  1 
ATOM   3947 S SG  . CYS   B 1 238 ? 12.44106  -13.53230 -9.64161  1.000 18.95591 ? 593  CYS   B SG  1 
ATOM   3948 N N   . PRO   B 1 239 ? 12.82467  -14.82643 -6.25803  1.000 13.64494 ? 594  PRO   B N   1 
ATOM   3949 C CA  . PRO   B 1 239 ? 13.53787  -16.05768 -5.83047  1.000 14.31303 ? 594  PRO   B CA  1 
ATOM   3950 C C   . PRO   B 1 239 ? 14.40396  -16.59971 -6.94815  1.000 16.93402 ? 594  PRO   B C   1 
ATOM   3951 O O   . PRO   B 1 239 ? 14.04827  -16.48270 -8.11280  1.000 17.30217 ? 594  PRO   B O   1 
ATOM   3952 C CB  . PRO   B 1 239 ? 12.40864  -17.04566 -5.49789  1.000 13.10148 ? 594  PRO   B CB  1 
ATOM   3953 C CG  . PRO   B 1 239 ? 11.27523  -16.06075 -5.06563  1.000 13.33954 ? 594  PRO   B CG  1 
ATOM   3954 C CD  . PRO   B 1 239 ? 11.35533  -14.89978 -6.02437  1.000 13.34698 ? 594  PRO   B CD  1 
ATOM   3955 N N   . ALA   B 1 240 ? 15.49021  -17.27386 -6.56606  1.000 17.07979 ? 595  ALA   B N   1 
ATOM   3956 C CA  . ALA   B 1 240 ? 16.30160  -17.96490 -7.58389  1.000 22.09991 ? 595  ALA   B CA  1 
ATOM   3957 C C   . ALA   B 1 240 ? 15.44825  -18.90706 -8.40468  1.000 20.36761 ? 595  ALA   B C   1 
ATOM   3958 O O   . ALA   B 1 240 ? 14.70338  -19.72413 -7.85835  1.000 19.65761 ? 595  ALA   B O   1 
ATOM   3959 C CB  . ALA   B 1 240 ? 17.42942  -18.73897 -6.90658  1.000 20.18518 ? 595  ALA   B CB  1 
ATOM   3960 N N   . GLY   B 1 241 ? 15.56696  -18.79724 -9.72552  1.000 19.19472 ? 596  GLY   B N   1 
ATOM   3961 C CA  . GLY   B 1 241 ? 14.85895  -19.67729 -10.63605 1.000 20.60398 ? 596  GLY   B CA  1 
ATOM   3962 C C   . GLY   B 1 241 ? 13.41162  -19.33126 -10.90181 1.000 20.41624 ? 596  GLY   B C   1 
ATOM   3963 O O   . GLY   B 1 241 ? 12.75582  -20.03623 -11.69206 1.000 23.82365 ? 596  GLY   B O   1 
ATOM   3964 N N   . CYS   B 1 242 ? 12.88604  -18.25461 -10.29556 1.000 16.77177 ? 597  CYS   B N   1 
ATOM   3965 C CA  . CYS   B 1 242 ? 11.48983  -17.92251 -10.46503 1.000 18.55189 ? 597  CYS   B CA  1 
ATOM   3966 C C   . CYS   B 1 242 ? 11.30314  -17.16887 -11.77790 1.000 19.81739 ? 597  CYS   B C   1 
ATOM   3967 O O   . CYS   B 1 242 ? 12.00354  -16.18033 -12.01741 1.000 20.91482 ? 597  CYS   B O   1 
ATOM   3968 C CB  . CYS   B 1 242 ? 11.00934  -17.08027 -9.25617  1.000 16.49594 ? 597  CYS   B CB  1 
ATOM   3969 S SG  . CYS   B 1 242 ? 9.33807   -16.55666 -9.40468  1.000 18.55326 ? 597  CYS   B SG  1 
ATOM   3970 N N   . PRO   B 1 243 ? 10.36712  -17.58403 -12.63576 1.000 18.50382 ? 598  PRO   B N   1 
ATOM   3971 C CA  . PRO   B 1 243 ? 10.14154  -16.86343 -13.89442 1.000 19.50551 ? 598  PRO   B CA  1 
ATOM   3972 C C   . PRO   B 1 243 ? 9.74575   -15.41786 -13.67896 1.000 19.34471 ? 598  PRO   B C   1 
ATOM   3973 O O   . PRO   B 1 243 ? 9.01223   -15.07972 -12.74445 1.000 17.89434 ? 598  PRO   B O   1 
ATOM   3974 C CB  . PRO   B 1 243 ? 8.99904   -17.64254 -14.54436 1.000 23.69304 ? 598  PRO   B CB  1 
ATOM   3975 C CG  . PRO   B 1 243 ? 9.10574   -19.02058 -13.95785 1.000 24.61620 ? 598  PRO   B CG  1 
ATOM   3976 C CD  . PRO   B 1 243 ? 9.57894   -18.83052 -12.55275 1.000 20.29138 ? 598  PRO   B CD  1 
ATOM   3977 N N   . ARG   B 1 244 ? 10.21570  -14.55308 -14.57937 1.000 18.76243 ? 599  ARG   B N   1 
ATOM   3978 C CA  . ARG   B 1 244 ? 9.85180   -13.14580 -14.47949 1.000 19.10169 ? 599  ARG   B CA  1 
ATOM   3979 C C   . ARG   B 1 244 ? 8.34163   -12.92569 -14.40455 1.000 16.83957 ? 599  ARG   B C   1 
ATOM   3980 O O   . ARG   B 1 244 ? 7.87177   -12.09072 -13.61417 1.000 18.22432 ? 599  ARG   B O   1 
ATOM   3981 C CB  . ARG   B 1 244 ? 10.48911  -12.38348 -15.65355 1.000 23.36079 ? 599  ARG   B CB  1 
ATOM   3982 C CG  . ARG   B 1 244 ? 11.86041  -11.86592 -15.22556 1.000 40.22446 ? 599  ARG   B CG  1 
ATOM   3983 C CD  . ARG   B 1 244 ? 11.68937  -10.79229 -14.12166 1.000 41.99712 ? 599  ARG   B CD  1 
ATOM   3984 N NE  . ARG   B 1 244 ? 12.66156  -10.91374 -13.03996 1.000 39.19685 ? 599  ARG   B NE  1 
ATOM   3985 C CZ  . ARG   B 1 244 ? 12.97752  -9.93345  -12.19893 1.000 42.36736 ? 599  ARG   B CZ  1 
ATOM   3986 N NH1 . ARG   B 1 244 ? 12.36148  -8.76284  -12.24015 1.000 44.57366 ? 599  ARG   B NH1 1 
ATOM   3987 N NH2 . ARG   B 1 244 ? 13.94661  -10.12773 -11.30163 1.000 44.05575 ? 599  ARG   B NH2 1 
ATOM   3988 N N   . GLU   B 1 245 ? 7.56625   -13.69227 -15.17569 1.000 17.73110 ? 600  GLU   B N   1 
ATOM   3989 C CA  . GLU   B 1 245 ? 6.12067   -13.51382 -15.20558 1.000 18.32547 ? 600  GLU   B CA  1 
ATOM   3990 C C   . GLU   B 1 245 ? 5.51115   -13.79846 -13.83661 1.000 17.04727 ? 600  GLU   B C   1 
ATOM   3991 O O   . GLU   B 1 245 ? 4.53642   -13.14188 -13.43085 1.000 18.27388 ? 600  GLU   B O   1 
ATOM   3992 C CB  . GLU   B 1 245 ? 5.50113   -14.44846 -16.25106 1.000 21.99105 ? 600  GLU   B CB  1 
ATOM   3993 C CG  . GLU   B 1 245 ? 5.91237   -14.10137 -17.70606 1.000 29.00592 ? 600  GLU   B CG  1 
ATOM   3994 C CD  . GLU   B 1 245 ? 7.23767   -14.70771 -18.18356 1.000 29.64020 ? 600  GLU   B CD  1 
ATOM   3995 O OE1 . GLU   B 1 245 ? 8.05533   -15.27623 -17.40642 1.000 23.63768 ? 600  GLU   B OE1 1 
ATOM   3996 O OE2 . GLU   B 1 245 ? 7.47198   -14.61569 -19.41619 1.000 41.97763 ? 600  GLU   B OE2 1 
ATOM   3997 N N   . MET   B 1 246 ? 6.06821   -14.77293 -13.12946 1.000 17.70963 ? 601  MET   B N   1 
ATOM   3998 C CA  . MET   B 1 246 ? 5.57518   -15.10122 -11.79754 1.000 15.49058 ? 601  MET   B CA  1 
ATOM   3999 C C   . MET   B 1 246 ? 5.98745   -14.05411 -10.77465 1.000 18.05051 ? 601  MET   B C   1 
ATOM   4000 O O   . MET   B 1 246 ? 5.19220   -13.71041 -9.88708  1.000 14.68008 ? 601  MET   B O   1 
ATOM   4001 C CB  . MET   B 1 246 ? 6.05716   -16.48054 -11.39801 1.000 15.39616 ? 601  MET   B CB  1 
ATOM   4002 C CG  . MET   B 1 246 ? 5.46356   -17.59903 -12.35257 1.000 16.41310 ? 601  MET   B CG  1 
ATOM   4003 S SD  . MET   B 1 246 ? 3.70355   -17.79282 -12.08985 1.000 18.77904 ? 601  MET   B SD  1 
ATOM   4004 C CE  . MET   B 1 246 ? 2.98304   -16.71630 -13.30146 1.000 19.25652 ? 601  MET   B CE  1 
ATOM   4005 N N   . TYR   B 1 247 ? 7.17386   -13.47223 -10.91919 1.000 15.43174 ? 602  TYR   B N   1 
ATOM   4006 C CA  . TYR   B 1 247 ? 7.55358   -12.39336 -10.01738 1.000 15.71557 ? 602  TYR   B CA  1 
ATOM   4007 C C   . TYR   B 1 247 ? 6.70847   -11.16044 -10.28579 1.000 14.75042 ? 602  TYR   B C   1 
ATOM   4008 O O   . TYR   B 1 247 ? 6.30776   -10.43599 -9.35375  1.000 15.20710 ? 602  TYR   B O   1 
ATOM   4009 C CB  . TYR   B 1 247 ? 9.02808   -12.06893 -10.20602 1.000 13.99825 ? 602  TYR   B CB  1 
ATOM   4010 C CG  . TYR   B 1 247 ? 9.54181   -11.06381 -9.23382  1.000 14.10876 ? 602  TYR   B CG  1 
ATOM   4011 C CD1 . TYR   B 1 247 ? 9.44660   -11.28389 -7.87261  1.000 14.60390 ? 602  TYR   B CD1 1 
ATOM   4012 C CD2 . TYR   B 1 247 ? 10.23872  -9.92707  -9.65883  1.000 17.06830 ? 602  TYR   B CD2 1 
ATOM   4013 C CE1 . TYR   B 1 247 ? 9.95272   -10.38362 -6.95165  1.000 16.09861 ? 602  TYR   B CE1 1 
ATOM   4014 C CE2 . TYR   B 1 247 ? 10.76589  -9.03863  -8.75027  1.000 18.56573 ? 602  TYR   B CE2 1 
ATOM   4015 C CZ  . TYR   B 1 247 ? 10.62516  -9.28180  -7.41368  1.000 18.89391 ? 602  TYR   B CZ  1 
ATOM   4016 O OH  . TYR   B 1 247 ? 11.15930  -8.40353  -6.50110  1.000 20.00893 ? 602  TYR   B OH  1 
ATOM   4017 N N   . ASP   B 1 248 ? 6.39398   -10.92483 -11.56322 1.000 14.30271 ? 603  ASP   B N   1 
ATOM   4018 C CA  . ASP   B 1 248 ? 5.51428   -9.83011  -11.89739 1.000 16.13420 ? 603  ASP   B CA  1 
ATOM   4019 C C   . ASP   B 1 248 ? 4.15688   -10.00850 -11.22556 1.000 13.84685 ? 603  ASP   B C   1 
ATOM   4020 O O   . ASP   B 1 248 ? 3.60391   -9.05474  -10.67569 1.000 14.62909 ? 603  ASP   B O   1 
ATOM   4021 C CB  . ASP   B 1 248 ? 5.33729   -9.72972  -13.41273 1.000 15.81946 ? 603  ASP   B CB  1 
ATOM   4022 C CG  . ASP   B 1 248 ? 6.59710   -9.30074  -14.11647 1.000 23.89698 ? 603  ASP   B CG  1 
ATOM   4023 O OD1 . ASP   B 1 248 ? 7.53746   -8.83121  -13.43167 1.000 24.56908 ? 603  ASP   B OD1 1 
ATOM   4024 O OD2 . ASP   B 1 248 ? 6.61376   -9.42769  -15.36576 1.000 27.75001 ? 603  ASP   B OD2 1 
ATOM   4025 N N   . LEU   B 1 249 ? 3.63199   -11.23266 -11.22852 1.000 14.73473 ? 604  LEU   B N   1 
ATOM   4026 C CA  . LEU   B 1 249 ? 2.35244   -11.51661 -10.58496 1.000 15.28769 ? 604  LEU   B CA  1 
ATOM   4027 C C   . LEU   B 1 249 ? 2.43076   -11.34303 -9.07166  1.000 15.25083 ? 604  LEU   B C   1 
ATOM   4028 O O   . LEU   B 1 249 ? 1.50560   -10.78404 -8.47750  1.000 13.93525 ? 604  LEU   B O   1 
ATOM   4029 C CB  . LEU   B 1 249 ? 1.89020   -12.93223 -10.94394 1.000 15.73204 ? 604  LEU   B CB  1 
ATOM   4030 C CG  . LEU   B 1 249 ? 0.53569   -13.30746 -10.33392 1.000 14.48171 ? 604  LEU   B CG  1 
ATOM   4031 C CD1 . LEU   B 1 249 ? -0.56732  -12.32420 -10.73658 1.000 16.37488 ? 604  LEU   B CD1 1 
ATOM   4032 C CD2 . LEU   B 1 249 ? 0.16893   -14.75148 -10.75300 1.000 15.67646 ? 604  LEU   B CD2 1 
ATOM   4033 N N   . MET   B 1 250 ? 3.51144   -11.79962 -8.43567  1.000 14.34264 ? 605  MET   B N   1 
ATOM   4034 C CA  . MET   B 1 250 ? 3.69208   -11.54060 -7.00452  1.000 13.08750 ? 605  MET   B CA  1 
ATOM   4035 C C   . MET   B 1 250 ? 3.61029   -10.06433 -6.74520  1.000 14.16436 ? 605  MET   B C   1 
ATOM   4036 O O   . MET   B 1 250 ? 2.93446   -9.61833  -5.81645  1.000 13.05546 ? 605  MET   B O   1 
ATOM   4037 C CB  . MET   B 1 250 ? 5.08908   -11.97937 -6.51457  1.000 16.04079 ? 605  MET   B CB  1 
ATOM   4038 C CG  . MET   B 1 250 ? 5.25871   -13.45707 -6.41193  1.000 20.06172 ? 605  MET   B CG  1 
ATOM   4039 S SD  . MET   B 1 250 ? 7.02294   -13.74507 -5.99140  1.000 17.75462 ? 605  MET   B SD  1 
ATOM   4040 C CE  . MET   B 1 250 ? 7.07467   -15.39108 -6.64165  1.000 20.50111 ? 605  MET   B CE  1 
ATOM   4041 N N   . ASN   B 1 251 ? 4.26630   -9.26803  -7.59894  1.000 12.82885 ? 606  ASN   B N   1 
ATOM   4042 C CA  . ASN   B 1 251 ? 4.28736   -7.83322  -7.31710  1.000 13.68154 ? 606  ASN   B CA  1 
ATOM   4043 C C   . ASN   B 1 251 ? 2.92900   -7.17661  -7.53395  1.000 13.09205 ? 606  ASN   B C   1 
ATOM   4044 O O   . ASN   B 1 251 ? 2.57437   -6.21651  -6.84317  1.000 14.49027 ? 606  ASN   B O   1 
ATOM   4045 C CB  . ASN   B 1 251 ? 5.36278   -7.11575  -8.14811  1.000 16.19664 ? 606  ASN   B CB  1 
ATOM   4046 C CG  . ASN   B 1 251 ? 6.67458   -7.08537  -7.44189  1.000 17.72382 ? 606  ASN   B CG  1 
ATOM   4047 O OD1 . ASN   B 1 251 ? 6.87300   -6.34581  -6.47312  1.000 16.83479 ? 606  ASN   B OD1 1 
ATOM   4048 N ND2 . ASN   B 1 251 ? 7.61962   -7.95706  -7.88263  1.000 23.07071 ? 606  ASN   B ND2 1 
ATOM   4049 N N   . LEU   B 1 252 ? 2.13872   -7.69289  -8.46257  1.000 13.16226 ? 607  LEU   B N   1 
ATOM   4050 C CA  . LEU   B 1 252 ? 0.77082   -7.19024  -8.64617  1.000 14.78036 ? 607  LEU   B CA  1 
ATOM   4051 C C   . LEU   B 1 252 ? -0.09415  -7.54205  -7.43039  1.000 13.62412 ? 607  LEU   B C   1 
ATOM   4052 O O   . LEU   B 1 252 ? -0.93704  -6.74599  -6.98576  1.000 15.16493 ? 607  LEU   B O   1 
ATOM   4053 C CB  . LEU   B 1 252 ? 0.16655   -7.77674  -9.92986  1.000 18.15809 ? 607  LEU   B CB  1 
ATOM   4054 C CG  . LEU   B 1 252 ? -1.22758  -7.32153  -10.30493 1.000 21.28686 ? 607  LEU   B CG  1 
ATOM   4055 C CD1 . LEU   B 1 252 ? -1.14292  -5.83559  -10.62469 1.000 20.69479 ? 607  LEU   B CD1 1 
ATOM   4056 C CD2 . LEU   B 1 252 ? -1.73131  -8.14450  -11.49872 1.000 20.51763 ? 607  LEU   B CD2 1 
ATOM   4057 N N   . CYS   B 1 253 ? 0.12896   -8.74242  -6.85210  1.000 12.88170 ? 608  CYS   B N   1 
ATOM   4058 C CA  . CYS   B 1 253 ? -0.57562  -9.08984  -5.61428  1.000 12.57472 ? 608  CYS   B CA  1 
ATOM   4059 C C   . CYS   B 1 253 ? -0.20467  -8.13345  -4.49998  1.000 12.74955 ? 608  CYS   B C   1 
ATOM   4060 O O   . CYS   B 1 253 ? -1.02795  -7.85719  -3.60086  1.000 15.15026 ? 608  CYS   B O   1 
ATOM   4061 C CB  . CYS   B 1 253 ? -0.26821  -10.53742 -5.16016  1.000 12.88342 ? 608  CYS   B CB  1 
ATOM   4062 S SG  . CYS   B 1 253 ? -0.90624  -11.80791 -6.26077  1.000 15.03933 ? 608  CYS   B SG  1 
ATOM   4063 N N   . TRP   B 1 254 ? 1.04131   -7.64221  -4.49567  1.000 12.10313 ? 609  TRP   B N   1 
ATOM   4064 C CA  . TRP   B 1 254 ? 1.51861   -6.67911  -3.48423  1.000 12.46171 ? 609  TRP   B CA  1 
ATOM   4065 C C   . TRP   B 1 254 ? 1.29831   -5.24396  -3.90153  1.000 11.73711 ? 609  TRP   B C   1 
ATOM   4066 O O   . TRP   B 1 254 ? 2.08733   -4.34459  -3.56633  1.000 13.38437 ? 609  TRP   B O   1 
ATOM   4067 C CB  . TRP   B 1 254 ? 3.00198   -6.87856  -3.18487  1.000 13.42136 ? 609  TRP   B CB  1 
ATOM   4068 C CG  . TRP   B 1 254 ? 3.33221   -8.29324  -2.73350  1.000 11.41124 ? 609  TRP   B CG  1 
ATOM   4069 C CD1 . TRP   B 1 254 ? 2.57181   -9.13674  -1.97741  1.000 11.43888 ? 609  TRP   B CD1 1 
ATOM   4070 C CD2 . TRP   B 1 254 ? 4.58323   -8.94489  -2.96061  1.000 10.62632 ? 609  TRP   B CD2 1 
ATOM   4071 N NE1 . TRP   B 1 254 ? 3.30734   -10.30533 -1.72562  1.000 12.25466 ? 609  TRP   B NE1 1 
ATOM   4072 C CE2 . TRP   B 1 254 ? 4.54109   -10.19149 -2.33897  1.000 10.54515 ? 609  TRP   B CE2 1 
ATOM   4073 C CE3 . TRP   B 1 254 ? 5.73924   -8.58267  -3.67244  1.000 11.20877 ? 609  TRP   B CE3 1 
ATOM   4074 C CZ2 . TRP   B 1 254 ? 5.59737   -11.12240 -2.41393  1.000 11.71638 ? 609  TRP   B CZ2 1 
ATOM   4075 C CZ3 . TRP   B 1 254 ? 6.82393   -9.51362  -3.71644  1.000 11.95590 ? 609  TRP   B CZ3 1 
ATOM   4076 C CH2 . TRP   B 1 254 ? 6.73417   -10.74406 -3.07388  1.000 14.01049 ? 609  TRP   B CH2 1 
ATOM   4077 N N   . THR   B 1 255 ? 0.17811   -5.00122  -4.56895  1.000 12.64449 ? 610  THR   B N   1 
ATOM   4078 C CA  . THR   B 1 255 ? -0.25098  -3.62573  -4.82411  1.000 14.25698 ? 610  THR   B CA  1 
ATOM   4079 C C   . THR   B 1 255 ? -0.72016  -2.98397  -3.50955  1.000 14.77125 ? 610  THR   B C   1 
ATOM   4080 O O   . THR   B 1 255 ? -1.57784  -3.52729  -2.81041  1.000 15.08979 ? 610  THR   B O   1 
ATOM   4081 C CB  . THR   B 1 255 ? -1.37219  -3.64382  -5.84435  1.000 13.46816 ? 610  THR   B CB  1 
ATOM   4082 O OG1 . THR   B 1 255 ? -0.89152  -4.14142  -7.10456  1.000 17.11828 ? 610  THR   B OG1 1 
ATOM   4083 C CG2 . THR   B 1 255 ? -1.98614  -2.24902  -5.99934  1.000 15.10387 ? 610  THR   B CG2 1 
ATOM   4084 N N   . TYR   B 1 256 ? -0.16142  -1.83682  -3.15488  1.000 13.17739 ? 611  TYR   B N   1 
ATOM   4085 C CA  . TYR   B 1 256 ? -0.42700  -1.23534  -1.84697  1.000 13.71623 ? 611  TYR   B CA  1 
ATOM   4086 C C   . TYR   B 1 256 ? -1.89639  -0.87441  -1.70190  1.000 13.80271 ? 611  TYR   B C   1 
ATOM   4087 O O   . TYR   B 1 256 ? -2.52332  -1.15703  -0.65946  1.000 15.96216 ? 611  TYR   B O   1 
ATOM   4088 C CB  . TYR   B 1 256 ? 0.43379   0.03034   -1.69697  1.000 15.06900 ? 611  TYR   B CB  1 
ATOM   4089 C CG  . TYR   B 1 256 ? 0.39619   0.58646   -0.31785  1.000 14.44628 ? 611  TYR   B CG  1 
ATOM   4090 C CD1 . TYR   B 1 256 ? -0.57364  1.49497   0.03691   1.000 16.58507 ? 611  TYR   B CD1 1 
ATOM   4091 C CD2 . TYR   B 1 256 ? 1.32001   0.22575   0.63893   1.000 12.78926 ? 611  TYR   B CD2 1 
ATOM   4092 C CE1 . TYR   B 1 256 ? -0.63865  2.03732   1.31473   1.000 15.33010 ? 611  TYR   B CE1 1 
ATOM   4093 C CE2 . TYR   B 1 256 ? 1.27320   0.74517   1.94000   1.000 17.04645 ? 611  TYR   B CE2 1 
ATOM   4094 C CZ  . TYR   B 1 256 ? 0.28343   1.65060   2.26826   1.000 15.78954 ? 611  TYR   B CZ  1 
ATOM   4095 O OH  . TYR   B 1 256 ? 0.25936   2.15380   3.54639   1.000 19.80870 ? 611  TYR   B OH  1 
ATOM   4096 N N   . ASP   B 1 257 ? -2.44017  -0.19342  -2.70507  1.000 15.63877 ? 612  ASP   B N   1 
ATOM   4097 C CA  . ASP   B 1 257 ? -3.82619  0.29229   -2.62997  1.000 14.58303 ? 612  ASP   B CA  1 
ATOM   4098 C C   . ASP   B 1 257 ? -4.80992  -0.83137  -2.96619  1.000 15.65194 ? 612  ASP   B C   1 
ATOM   4099 O O   . ASP   B 1 257 ? -4.84153  -1.33464  -4.09405  1.000 17.23962 ? 612  ASP   B O   1 
ATOM   4100 C CB  . ASP   B 1 257 ? -4.05343  1.46121   -3.59008  1.000 17.36957 ? 612  ASP   B CB  1 
ATOM   4101 C CG  . ASP   B 1 257 ? -3.14427  2.63166   -3.33253  1.000 18.05921 ? 612  ASP   B CG  1 
ATOM   4102 O OD1 . ASP   B 1 257 ? -2.74972  2.90845   -2.19347  1.000 18.65031 ? 612  ASP   B OD1 1 
ATOM   4103 O OD2 . ASP   B 1 257 ? -2.88212  3.33366   -4.36554  1.000 20.29729 ? 612  ASP   B OD2 1 
ATOM   4104 N N   . VAL   B 1 258 ? -5.63043  -1.19056  -1.97746  1.000 20.46565 ? 613  VAL   B N   1 
ATOM   4105 C CA  . VAL   B 1 258 ? -6.51893  -2.34968  -2.13066  1.000 18.13768 ? 613  VAL   B CA  1 
ATOM   4106 C C   . VAL   B 1 258 ? -7.44297  -2.18418  -3.32047  1.000 18.41071 ? 613  VAL   B C   1 
ATOM   4107 O O   . VAL   B 1 258 ? -7.67662  -3.13694  -4.06675  1.000 19.96875 ? 613  VAL   B O   1 
ATOM   4108 C CB  . VAL   B 1 258 ? -7.25615  -2.59042  -0.78323  1.000 18.00506 ? 613  VAL   B CB  1 
ATOM   4109 C CG1 . VAL   B 1 258 ? -8.20301  -1.41526  -0.36911  1.000 24.85681 ? 613  VAL   B CG1 1 
ATOM   4110 C CG2 . VAL   B 1 258 ? -7.96713  -3.93755  -0.80317  1.000 22.06402 ? 613  VAL   B CG2 1 
ATOM   4111 N N   . GLU   B 1 259 ? -7.91330  -0.95242  -3.59378  1.000 21.15959 ? 614  GLU   B N   1 
ATOM   4112 C CA  . GLU   B 1 259 ? -8.78420  -0.80006  -4.75277  1.000 23.70664 ? 614  GLU   B CA  1 
ATOM   4113 C C   . GLU   B 1 259 ? -8.10854  -1.09611  -6.07822  1.000 21.88969 ? 614  GLU   B C   1 
ATOM   4114 O O   . GLU   B 1 259 ? -8.79862  -1.45774  -7.03882  1.000 24.30904 ? 614  GLU   B O   1 
ATOM   4115 C CB  . GLU   B 1 259 ? -9.38073  0.61451   -4.82958  1.000 26.87714 ? 614  GLU   B CB  1 
ATOM   4116 C CG  . GLU   B 1 259 ? -9.54095  1.33242   -3.48847  1.000 42.55724 ? 614  GLU   B CG  1 
ATOM   4117 C CD  . GLU   B 1 259 ? -8.32677  2.19902   -3.13239  1.000 49.97757 ? 614  GLU   B CD  1 
ATOM   4118 O OE1 . GLU   B 1 259 ? -7.39459  1.69404   -2.46165  1.000 27.88892 ? 614  GLU   B OE1 1 
ATOM   4119 O OE2 . GLU   B 1 259 ? -8.30014  3.39138   -3.53087  1.000 61.99034 ? 614  GLU   B OE2 1 
ATOM   4120 N N   . ASN   B 1 260 ? -6.77900  -0.98088  -6.17227  1.000 16.76594 ? 615  ASN   B N   1 
ATOM   4121 C CA  . ASN   B 1 260 ? -6.07501  -1.23722  -7.41347  1.000 18.45498 ? 615  ASN   B CA  1 
ATOM   4122 C C   . ASN   B 1 260 ? -5.44167  -2.62578  -7.45640  1.000 18.13583 ? 615  ASN   B C   1 
ATOM   4123 O O   . ASN   B 1 260 ? -4.84939  -3.00455  -8.46132  1.000 21.00531 ? 615  ASN   B O   1 
ATOM   4124 C CB  . ASN   B 1 260 ? -5.00903  -0.16323  -7.60490  1.000 18.79970 ? 615  ASN   B CB  1 
ATOM   4125 C CG  . ASN   B 1 260 ? -5.59216  1.26165   -7.53264  1.000 27.10495 ? 615  ASN   B CG  1 
ATOM   4126 O OD1 . ASN   B 1 260 ? -6.73726  1.49095   -7.92147  1.000 27.72101 ? 615  ASN   B OD1 1 
ATOM   4127 N ND2 . ASN   B 1 260 ? -4.81377  2.20536   -7.01437  1.000 24.09688 ? 615  ASN   B ND2 1 
ATOM   4128 N N   . ARG   B 1 261 ? -5.61306  -3.39099  -6.42857  1.000 16.11271 ? 616  ARG   B N   1 
ATOM   4129 C CA  . ARG   B 1 261 ? -5.06347  -4.74642  -6.39404  1.000 14.37447 ? 616  ARG   B CA  1 
ATOM   4130 C C   . ARG   B 1 261 ? -6.02909  -5.68914  -7.11703  1.000 15.17799 ? 616  ARG   B C   1 
ATOM   4131 O O   . ARG   B 1 261 ? -7.24694  -5.51995  -7.00128  1.000 18.61007 ? 616  ARG   B O   1 
ATOM   4132 C CB  . ARG   B 1 261 ? -4.90956  -5.14571  -4.93476  1.000 14.70838 ? 616  ARG   B CB  1 
ATOM   4133 C CG  . ARG   B 1 261 ? -4.12452  -6.45727  -4.68768  1.000 13.94128 ? 616  ARG   B CG  1 
ATOM   4134 C CD  . ARG   B 1 261 ? -4.06103  -6.75688  -3.16133  1.000 14.11988 ? 616  ARG   B CD  1 
ATOM   4135 N NE  . ARG   B 1 261 ? -3.53013  -5.63679  -2.37139  1.000 12.13543 ? 616  ARG   B NE  1 
ATOM   4136 C CZ  . ARG   B 1 261 ? -3.96242  -5.24008  -1.17878  1.000 15.14449 ? 616  ARG   B CZ  1 
ATOM   4137 N NH1 . ARG   B 1 261 ? -4.83682  -5.97730  -0.46598  1.000 14.59813 ? 616  ARG   B NH1 1 
ATOM   4138 N NH2 . ARG   B 1 261 ? -3.48427  -4.10201  -0.66287  1.000 14.95788 ? 616  ARG   B NH2 1 
ATOM   4139 N N   . PRO   B 1 262 ? -5.55558  -6.69353  -7.84199  1.000 15.30708 ? 617  PRO   B N   1 
ATOM   4140 C CA  . PRO   B 1 262 ? -6.48947  -7.62264  -8.49622  1.000 17.31412 ? 617  PRO   B CA  1 
ATOM   4141 C C   . PRO   B 1 262 ? -7.19550  -8.52433  -7.48035  1.000 17.31398 ? 617  PRO   B C   1 
ATOM   4142 O O   . PRO   B 1 262 ? -6.69083  -8.78764  -6.38324  1.000 17.23861 ? 617  PRO   B O   1 
ATOM   4143 C CB  . PRO   B 1 262 ? -5.58209  -8.46124  -9.40226  1.000 19.44059 ? 617  PRO   B CB  1 
ATOM   4144 C CG  . PRO   B 1 262 ? -4.27488  -8.42908  -8.72306  1.000 19.77903 ? 617  PRO   B CG  1 
ATOM   4145 C CD  . PRO   B 1 262 ? -4.15774  -7.05299  -8.12000  1.000 17.66970 ? 617  PRO   B CD  1 
ATOM   4146 N N   . GLY   B 1 263 ? -8.37661  -9.02777  -7.89228  1.000 18.88288 ? 618  GLY   B N   1 
ATOM   4147 C CA  . GLY   B 1 263 ? -9.03728  -10.11273 -7.20035  1.000 17.87822 ? 618  GLY   B CA  1 
ATOM   4148 C C   . GLY   B 1 263 ? -8.55502  -11.46421 -7.71849  1.000 14.46237 ? 618  GLY   B C   1 
ATOM   4149 O O   . GLY   B 1 263 ? -7.74435  -11.57841 -8.65040  1.000 16.42292 ? 618  GLY   B O   1 
ATOM   4150 N N   . PHE   B 1 264 ? -9.05102  -12.52369 -7.07431  1.000 14.92469 ? 619  PHE   B N   1 
ATOM   4151 C CA  . PHE   B 1 264 ? -8.58919  -13.86970 -7.39949  1.000 14.91449 ? 619  PHE   B CA  1 
ATOM   4152 C C   . PHE   B 1 264 ? -9.03169  -14.34392 -8.77315  1.000 16.13621 ? 619  PHE   B C   1 
ATOM   4153 O O   . PHE   B 1 264 ? -8.34388  -15.16476 -9.35506  1.000 16.17372 ? 619  PHE   B O   1 
ATOM   4154 C CB  . PHE   B 1 264 ? -8.99293  -14.91307 -6.34986  1.000 15.11682 ? 619  PHE   B CB  1 
ATOM   4155 C CG  . PHE   B 1 264 ? -8.08417  -14.92019 -5.19063  1.000 14.09117 ? 619  PHE   B CG  1 
ATOM   4156 C CD1 . PHE   B 1 264 ? -6.79144  -15.37177 -5.31220  1.000 12.14377 ? 619  PHE   B CD1 1 
ATOM   4157 C CD2 . PHE   B 1 264 ? -8.53109  -14.41506 -3.99040  1.000 13.36235 ? 619  PHE   B CD2 1 
ATOM   4158 C CE1 . PHE   B 1 264 ? -5.95358  -15.32580 -4.16978  1.000 12.32628 ? 619  PHE   B CE1 1 
ATOM   4159 C CE2 . PHE   B 1 264 ? -7.70743  -14.35486 -2.84867  1.000 13.15533 ? 619  PHE   B CE2 1 
ATOM   4160 C CZ  . PHE   B 1 264 ? -6.39523  -14.82129 -2.95090  1.000 13.07775 ? 619  PHE   B CZ  1 
ATOM   4161 N N   . ALA   B 1 265 ? -10.10326 -13.79736 -9.35013  1.000 19.71135 ? 620  ALA   B N   1 
ATOM   4162 C CA  . ALA   B 1 265 ? -10.42341 -14.20537 -10.71571 1.000 22.42757 ? 620  ALA   B CA  1 
ATOM   4163 C C   . ALA   B 1 265 ? -9.32559  -13.78184 -11.68257 1.000 16.00557 ? 620  ALA   B C   1 
ATOM   4164 O O   . ALA   B 1 265 ? -8.85934  -14.59138 -12.51148 1.000 19.00350 ? 620  ALA   B O   1 
ATOM   4165 C CB  . ALA   B 1 265 ? -11.78703 -13.63134 -11.13692 1.000 21.15179 ? 620  ALA   B CB  1 
ATOM   4166 N N   . ALA   B 1 266 ? -8.85216  -12.53557 -11.54495 1.000 18.31554 ? 621  ALA   B N   1 
ATOM   4167 C CA  . ALA   B 1 266 ? -7.74670  -12.07951 -12.38566 1.000 17.73303 ? 621  ALA   B CA  1 
ATOM   4168 C C   . ALA   B 1 266 ? -6.45719  -12.83158 -12.08082 1.000 17.76691 ? 621  ALA   B C   1 
ATOM   4169 O O   . ALA   B 1 266 ? -5.68531  -13.17063 -12.99278 1.000 18.75216 ? 621  ALA   B O   1 
ATOM   4170 C CB  . ALA   B 1 266 ? -7.55141  -10.58167 -12.20110 1.000 21.34215 ? 621  ALA   B CB  1 
ATOM   4171 N N   . VAL   B 1 267 ? -6.18554  -13.10027 -10.79170 1.000 16.58140 ? 622  VAL   B N   1 
ATOM   4172 C CA  . VAL   B 1 267 ? -4.94805  -13.79412 -10.44470 1.000 15.91025 ? 622  VAL   B CA  1 
ATOM   4173 C C   . VAL   B 1 267 ? -4.94530  -15.22136 -10.99226 1.000 15.88706 ? 622  VAL   B C   1 
ATOM   4174 O O   . VAL   B 1 267 ? -3.94508  -15.69043 -11.54764 1.000 17.04692 ? 622  VAL   B O   1 
ATOM   4175 C CB  . VAL   B 1 267 ? -4.75804  -13.77591 -8.91219  1.000 14.09301 ? 622  VAL   B CB  1 
ATOM   4176 C CG1 . VAL   B 1 267 ? -3.58347  -14.65974 -8.48545  1.000 14.66264 ? 622  VAL   B CG1 1 
ATOM   4177 C CG2 . VAL   B 1 267 ? -4.48834  -12.33562 -8.39196  1.000 15.03451 ? 622  VAL   B CG2 1 
ATOM   4178 N N   . GLU   B 1 268 ? -6.03284  -15.95345 -10.77426 1.000 14.44734 ? 623  GLU   B N   1 
ATOM   4179 C CA  . GLU   B 1 268 ? -6.14257  -17.32781 -11.26699 1.000 14.69078 ? 623  GLU   B CA  1 
ATOM   4180 C C   . GLU   B 1 268 ? -5.99160  -17.39172 -12.78879 1.000 16.47357 ? 623  GLU   B C   1 
ATOM   4181 O O   . GLU   B 1 268 ? -5.32204  -18.28362 -13.31339 1.000 17.26582 ? 623  GLU   B O   1 
ATOM   4182 C CB  . GLU   B 1 268 ? -7.49152  -17.93139 -10.81866 1.000 19.05678 ? 623  GLU   B CB  1 
ATOM   4183 C CG  . GLU   B 1 268 ? -7.66401  -19.41515 -11.15790 1.000 17.49873 ? 623  GLU   B CG  1 
ATOM   4184 C CD  . GLU   B 1 268 ? -8.08679  -19.72623 -12.60356 1.000 20.64260 ? 623  GLU   B CD  1 
ATOM   4185 O OE1 . GLU   B 1 268 ? -8.79577  -18.87472 -13.18073 1.000 23.37580 ? 623  GLU   B OE1 1 
ATOM   4186 O OE2 . GLU   B 1 268 ? -7.69911  -20.79884 -13.12255 1.000 19.35732 ? 623  GLU   B OE2 1 
ATOM   4187 N N   . LEU   B 1 269 ? -6.60026  -16.44805 -13.49504 1.000 19.14162 ? 624  LEU   B N   1 
ATOM   4188 C CA  . LEU   B 1 269 ? -6.51362  -16.44338 -14.96191 1.000 20.50562 ? 624  LEU   B CA  1 
ATOM   4189 C C   . LEU   B 1 269 ? -5.07881  -16.22958 -15.41915 1.000 19.34654 ? 624  LEU   B C   1 
ATOM   4190 O O   . LEU   B 1 269 ? -4.59822  -16.89571 -16.33810 1.000 20.10281 ? 624  LEU   B O   1 
ATOM   4191 C CB  . LEU   B 1 269 ? -7.44618  -15.35768 -15.52235 1.000 20.27445 ? 624  LEU   B CB  1 
ATOM   4192 C CG  . LEU   B 1 269 ? -7.45729  -15.28072 -17.06226 1.000 27.58678 ? 624  LEU   B CG  1 
ATOM   4193 C CD1 . LEU   B 1 269 ? -7.81464  -16.62393 -17.69107 1.000 25.89542 ? 624  LEU   B CD1 1 
ATOM   4194 C CD2 . LEU   B 1 269 ? -8.37827  -14.16395 -17.53390 1.000 26.35264 ? 624  LEU   B CD2 1 
ATOM   4195 N N   . ARG   B 1 270 ? -4.35475  -15.31639 -14.76004 1.000 16.80251 ? 625  ARG   B N   1 
ATOM   4196 C CA  . ARG   B 1 270 ? -2.95645  -15.12896 -15.13811 1.000 18.72419 ? 625  ARG   B CA  1 
ATOM   4197 C C   . ARG   B 1 270 ? -2.14431  -16.38822 -14.90757 1.000 20.04885 ? 625  ARG   B C   1 
ATOM   4198 O O   . ARG   B 1 270 ? -1.30451  -16.77225 -15.73968 1.000 19.92110 ? 625  ARG   B O   1 
ATOM   4199 C CB  . ARG   B 1 270 ? -2.34043  -13.96732 -14.34811 1.000 17.84080 ? 625  ARG   B CB  1 
ATOM   4200 C CG  . ARG   B 1 270 ? -0.87035  -13.76464 -14.69445 1.000 25.51839 ? 625  ARG   B CG  1 
ATOM   4201 C CD  . ARG   B 1 270 ? -0.72839  -12.69459 -15.75073 1.000 40.72288 ? 625  ARG   B CD  1 
ATOM   4202 N NE  . ARG   B 1 270 ? -1.51833  -11.52136 -15.39202 1.000 42.53035 ? 625  ARG   B NE  1 
ATOM   4203 C CZ  . ARG   B 1 270 ? -1.02362  -10.40913 -14.86200 1.000 50.53131 ? 625  ARG   B CZ  1 
ATOM   4204 N NH1 . ARG   B 1 270 ? 0.27187   -10.28782 -14.58030 1.000 41.51795 ? 625  ARG   B NH1 1 
ATOM   4205 N NH2 . ARG   B 1 270 ? -1.84420  -9.39010  -14.62049 1.000 46.47126 ? 625  ARG   B NH2 1 
ATOM   4206 N N   . LEU   B 1 271 ? -2.33345  -17.03309 -13.74993 1.000 18.77430 ? 626  LEU   B N   1 
ATOM   4207 C CA  . LEU   B 1 271 ? -1.60255  -18.25958 -13.47015 1.000 17.02943 ? 626  LEU   B CA  1 
ATOM   4208 C C   . LEU   B 1 271 ? -1.99334  -19.36990 -14.43202 1.000 17.38831 ? 626  LEU   B C   1 
ATOM   4209 O O   . LEU   B 1 271 ? -1.15092  -20.20027 -14.78927 1.000 19.19119 ? 626  LEU   B O   1 
ATOM   4210 C CB  . LEU   B 1 271 ? -1.88758  -18.70844 -12.03350 1.000 18.26386 ? 626  LEU   B CB  1 
ATOM   4211 C CG  . LEU   B 1 271 ? -0.92285  -18.08608 -11.06595 1.000 16.55394 ? 626  LEU   B CG  1 
ATOM   4212 C CD1 . LEU   B 1 271 ? -1.50291  -18.24794 -9.66408  1.000 15.29510 ? 626  LEU   B CD1 1 
ATOM   4213 C CD2 . LEU   B 1 271 ? 0.42020   -18.74101 -11.13009 1.000 18.53704 ? 626  LEU   B CD2 1 
ATOM   4214 N N   . ARG   B 1 272 ? -3.28519  -19.45144 -14.76308 1.000 18.02134 ? 627  ARG   B N   1 
ATOM   4215 C CA  . ARG   B 1 272 ? -3.77358  -20.52991 -15.62165 1.000 18.95069 ? 627  ARG   B CA  1 
ATOM   4216 C C   . ARG   B 1 272 ? -3.11495  -20.39559 -16.97011 1.000 21.56085 ? 627  ARG   B C   1 
ATOM   4217 O O   . ARG   B 1 272 ? -2.55821  -21.34783 -17.50039 1.000 20.06144 ? 627  ARG   B O   1 
ATOM   4218 C CB  . ARG   B 1 272 ? -5.28688  -20.41293 -15.76451 1.000 19.91324 ? 627  ARG   B CB  1 
ATOM   4219 C CG  . ARG   B 1 272 ? -5.91681  -21.58948 -16.54172 1.000 24.29609 ? 627  ARG   B CG  1 
ATOM   4220 C CD  . ARG   B 1 272 ? -7.24497  -21.15584 -17.13530 1.000 27.64850 ? 627  ARG   B CD  1 
ATOM   4221 N NE  . ARG   B 1 272 ? -8.10302  -20.44566 -16.20306 1.000 31.02789 ? 627  ARG   B NE  1 
ATOM   4222 C CZ  . ARG   B 1 272 ? -9.26625  -19.89817 -16.53648 1.000 31.68652 ? 627  ARG   B CZ  1 
ATOM   4223 N NH1 . ARG   B 1 272 ? -9.78619  -20.05920 -17.74932 1.000 37.60340 ? 627  ARG   B NH1 1 
ATOM   4224 N NH2 . ARG   B 1 272 ? -9.92323  -19.16401 -15.63990 1.000 33.45698 ? 627  ARG   B NH2 1 
ATOM   4225 N N   . ASN   B 1 273 ? -3.10876  -19.18083 -17.48859 1.000 21.08105 ? 628  ASN   B N   1 
ATOM   4226 C CA  . ASN   B 1 273 ? -2.56149  -18.96183 -18.82213 1.000 23.49513 ? 628  ASN   B CA  1 
ATOM   4227 C C   . ASN   B 1 273 ? -1.06980  -19.21395 -18.83985 1.000 23.17288 ? 628  ASN   B C   1 
ATOM   4228 O O   . ASN   B 1 273 ? -0.54474  -19.81644 -19.78597 1.000 22.19808 ? 628  ASN   B O   1 
ATOM   4229 C CB  . ASN   B 1 273 ? -2.86190  -17.53849 -19.28138 1.000 21.12925 ? 628  ASN   B CB  1 
ATOM   4230 C CG  . ASN   B 1 273 ? -4.30831  -17.35049 -19.69946 1.000 19.56606 ? 628  ASN   B CG  1 
ATOM   4231 O OD1 . ASN   B 1 273 ? -4.99655  -18.34955 -20.00526 1.000 25.17545 ? 628  ASN   B OD1 1 
ATOM   4232 N ND2 . ASN   B 1 273 ? -4.79338  -16.09366 -19.70756 1.000 24.45669 ? 628  ASN   B ND2 1 
ATOM   4233 N N   . TYR   B 1 274 ? -0.35425  -18.77527 -17.79765 1.000 18.99312 ? 629  TYR   B N   1 
ATOM   4234 C CA  . TYR   B 1 274 ? 1.08733   -19.01418 -17.79206 1.000 16.38124 ? 629  TYR   B CA  1 
ATOM   4235 C C   . TYR   B 1 274 ? 1.39693   -20.49735 -17.64416 1.000 21.32114 ? 629  TYR   B C   1 
ATOM   4236 O O   . TYR   B 1 274 ? 2.32049   -21.01911 -18.28793 1.000 22.36467 ? 629  TYR   B O   1 
ATOM   4237 C CB  . TYR   B 1 274 ? 1.79098   -18.18851 -16.66299 1.000 19.94535 ? 629  TYR   B CB  1 
ATOM   4238 C CG  . TYR   B 1 274 ? 3.29944   -18.25507 -16.81089 1.000 20.60779 ? 629  TYR   B CG  1 
ATOM   4239 C CD1 . TYR   B 1 274 ? 3.93305   -17.65875 -17.90498 1.000 20.70826 ? 629  TYR   B CD1 1 
ATOM   4240 C CD2 . TYR   B 1 274 ? 4.10090   -18.92558 -15.90943 1.000 22.94025 ? 629  TYR   B CD2 1 
ATOM   4241 C CE1 . TYR   B 1 274 ? 5.27335   -17.73033 -18.07700 1.000 21.58695 ? 629  TYR   B CE1 1 
ATOM   4242 C CE2 . TYR   B 1 274 ? 5.47293   -19.02409 -16.09663 1.000 21.38822 ? 629  TYR   B CE2 1 
ATOM   4243 C CZ  . TYR   B 1 274 ? 6.05393   -18.38905 -17.19689 1.000 21.34348 ? 629  TYR   B CZ  1 
ATOM   4244 O OH  . TYR   B 1 274 ? 7.41570   -18.45176 -17.44245 1.000 30.31557 ? 629  TYR   B OH  1 
ATOM   4245 N N   . TYR   B 1 275 ? 0.66416   -21.19360 -16.78006 1.000 17.69522 ? 630  TYR   B N   1 
ATOM   4246 C CA  . TYR   B 1 275 ? 0.89871   -22.61530 -16.60385 1.000 17.95320 ? 630  TYR   B CA  1 
ATOM   4247 C C   . TYR   B 1 275 ? 0.72828   -23.36711 -17.92435 1.000 20.82125 ? 630  TYR   B C   1 
ATOM   4248 O O   . TYR   B 1 275 ? 1.56664   -24.19338 -18.28183 1.000 20.83892 ? 630  TYR   B O   1 
ATOM   4249 C CB  . TYR   B 1 275 ? -0.04205  -23.17342 -15.53935 1.000 20.98194 ? 630  TYR   B CB  1 
ATOM   4250 C CG  . TYR   B 1 275 ? 0.11232   -24.66718 -15.33703 1.000 20.13895 ? 630  TYR   B CG  1 
ATOM   4251 C CD1 . TYR   B 1 275 ? 1.33977   -25.23577 -14.94480 1.000 19.62396 ? 630  TYR   B CD1 1 
ATOM   4252 C CD2 . TYR   B 1 275 ? -0.97249  -25.51220 -15.50943 1.000 23.09379 ? 630  TYR   B CD2 1 
ATOM   4253 C CE1 . TYR   B 1 275 ? 1.47756   -26.60520 -14.76062 1.000 22.36307 ? 630  TYR   B CE1 1 
ATOM   4254 C CE2 . TYR   B 1 275 ? -0.83598  -26.90114 -15.33156 1.000 27.02679 ? 630  TYR   B CE2 1 
ATOM   4255 C CZ  . TYR   B 1 275 ? 0.38266   -27.41887 -14.94296 1.000 21.66028 ? 630  TYR   B CZ  1 
ATOM   4256 O OH  . TYR   B 1 275 ? 0.56175   -28.75943 -14.75727 1.000 28.31305 ? 630  TYR   B OH  1 
ATOM   4257 N N   . TYR   B 1 276 ? -0.34589  -23.08574 -18.64507 1.000 20.22895 ? 631  TYR   B N   1 
ATOM   4258 C CA  . TYR   B 1 276 ? -0.56614  -23.84258 -19.88306 1.000 26.16372 ? 631  TYR   B CA  1 
ATOM   4259 C C   . TYR   B 1 276 ? 0.43650   -23.42957 -20.96939 1.000 32.11633 ? 631  TYR   B C   1 
ATOM   4260 O O   . TYR   B 1 276 ? 0.76141   -24.25000 -21.83924 1.000 30.12612 ? 631  TYR   B O   1 
ATOM   4261 C CB  . TYR   B 1 276 ? -2.06041  -23.73933 -20.23951 1.000 27.38781 ? 631  TYR   B CB  1 
ATOM   4262 C CG  . TYR   B 1 276 ? -2.83562  -24.66781 -19.28432 1.000 24.16081 ? 631  TYR   B CG  1 
ATOM   4263 C CD1 . TYR   B 1 276 ? -2.37302  -25.97851 -19.05262 1.000 27.69588 ? 631  TYR   B CD1 1 
ATOM   4264 C CD2 . TYR   B 1 276 ? -3.95567  -24.24916 -18.58057 1.000 27.29597 ? 631  TYR   B CD2 1 
ATOM   4265 C CE1 . TYR   B 1 276 ? -3.03391  -26.85491 -18.18975 1.000 35.69078 ? 631  TYR   B CE1 1 
ATOM   4266 C CE2 . TYR   B 1 276 ? -4.61528  -25.10447 -17.70666 1.000 30.32307 ? 631  TYR   B CE2 1 
ATOM   4267 C CZ  . TYR   B 1 276 ? -4.15107  -26.41114 -17.51193 1.000 35.17375 ? 631  TYR   B CZ  1 
ATOM   4268 O OH  . TYR   B 1 276 ? -4.79342  -27.28233 -16.64789 1.000 37.82355 ? 631  TYR   B OH  1 
ATOM   4269 N N   . ASP   B 1 277 ? 1.06157   -22.25215 -20.84159 1.000 26.05048 ? 632  ASP   B N   1 
ATOM   4270 C CA  . ASP   B 1 277 ? 2.17536   -21.88040 -21.72007 1.000 29.42615 ? 632  ASP   B CA  1 
ATOM   4271 C C   . ASP   B 1 277 ? 3.39845   -22.73831 -21.45471 1.000 28.69709 ? 632  ASP   B C   1 
ATOM   4272 O O   . ASP   B 1 277 ? 4.04559   -23.23314 -22.38623 1.000 35.44327 ? 632  ASP   B O   1 
ATOM   4273 C CB  . ASP   B 1 277 ? 2.55287   -20.41168 -21.52201 1.000 27.25779 ? 632  ASP   B CB  1 
ATOM   4274 C CG  . ASP   B 1 277 ? 1.54250   -19.46256 -22.10661 1.000 39.00407 ? 632  ASP   B CG  1 
ATOM   4275 O OD1 . ASP   B 1 277 ? 0.77925   -19.88401 -23.00421 1.000 47.40907 ? 632  ASP   B OD1 1 
ATOM   4276 O OD2 . ASP   B 1 277 ? 1.52050   -18.28346 -21.67198 1.000 50.68803 ? 632  ASP   B OD2 1 
ATOM   4277 N N   . VAL   B 1 278 ? 3.77662   -22.86573 -20.18644 1.000 24.77509 ? 633  VAL   B N   1 
ATOM   4278 C CA  . VAL   B 1 278 ? 4.92185   -23.67257 -19.79279 1.000 28.26915 ? 633  VAL   B CA  1 
ATOM   4279 C C   . VAL   B 1 278 ? 4.67453   -25.14103 -20.09136 1.000 31.96524 ? 633  VAL   B C   1 
ATOM   4280 O O   . VAL   B 1 278 ? 5.58877   -25.86173 -20.49652 1.000 43.31170 ? 633  VAL   B O   1 
ATOM   4281 C CB  . VAL   B 1 278 ? 5.23155   -23.44575 -18.29732 1.000 29.36893 ? 633  VAL   B CB  1 
ATOM   4282 C CG1 . VAL   B 1 278 ? 6.22469   -24.46382 -17.79018 1.000 31.43001 ? 633  VAL   B CG1 1 
ATOM   4283 C CG2 . VAL   B 1 278 ? 5.75353   -22.04378 -18.08306 1.000 30.20286 ? 633  VAL   B CG2 1 
ATOM   4284 N N   . VAL   B 1 279 ? 3.45203   -25.60871 -19.87777 1.000 28.83806 ? 634  VAL   B N   1 
ATOM   4285 C CA  . VAL   B 1 279 ? 3.07568   -26.98243 -20.21783 1.000 43.57773 ? 634  VAL   B CA  1 
ATOM   4286 C C   . VAL   B 1 279 ? 3.28115   -27.24272 -21.71226 1.000 40.99733 ? 634  VAL   B C   1 
ATOM   4287 O O   . VAL   B 1 279 ? 3.87495   -28.25578 -22.08326 1.000 38.22605 ? 634  VAL   B O   1 
ATOM   4288 C CB  . VAL   B 1 279 ? 1.62538   -27.27836 -19.79494 1.000 31.76386 ? 634  VAL   B CB  1 
ATOM   4289 C CG1 . VAL   B 1 279 ? 1.07654   -28.49474 -20.52788 1.000 41.55027 ? 634  VAL   B CG1 1 
ATOM   4290 C CG2 . VAL   B 1 279 ? 1.59134   -27.52379 -18.31144 1.000 33.13614 ? 634  VAL   B CG2 1 
HETATM 4291 N N1  . A1LV6 C 2 .   ? 16.41667  10.92989  36.78378  1.000 12.68491 ? 901  A1LV6 A N1  1 
HETATM 4292 N N3  . A1LV6 C 2 .   ? 17.58792  12.64270  37.98766  1.000 13.00016 ? 901  A1LV6 A N3  1 
HETATM 4293 C C4  . A1LV6 C 2 .   ? 16.41653  11.89952  37.73303  1.000 13.28108 ? 901  A1LV6 A C4  1 
HETATM 4294 C C5  . A1LV6 C 2 .   ? 18.84700  12.60131  37.28929  1.000 12.69159 ? 901  A1LV6 A C5  1 
HETATM 4295 C C6  . A1LV6 C 2 .   ? 19.17238  11.65604  36.35406  1.000 14.09457 ? 901  A1LV6 A C6  1 
HETATM 4296 C C7  . A1LV6 C 2 .   ? 20.42286  11.73972  35.76805  1.000 14.05936 ? 901  A1LV6 A C7  1 
HETATM 4297 C C8  . A1LV6 C 2 .   ? 21.29414  12.80465  36.19723  1.000 15.67276 ? 901  A1LV6 A C8  1 
HETATM 4298 C C10 . A1LV6 C 2 .   ? 22.48947  11.70326  34.69665  1.000 16.78853 ? 901  A1LV6 A C10 1 
HETATM 4299 C C13 . A1LV6 C 2 .   ? 20.75881  9.81338   34.07269  1.000 19.64723 ? 901  A1LV6 A C13 1 
HETATM 4300 C C15 . A1LV6 C 2 .   ? 21.82469  7.65877   33.06168  1.000 22.76796 ? 901  A1LV6 A C15 1 
HETATM 4301 C C17 . A1LV6 C 2 .   ? 16.43787  8.78719   34.98369  1.000 12.68108 ? 901  A1LV6 A C17 1 
HETATM 4302 C C20 . A1LV6 C 2 .   ? 13.75852  6.39652   34.10326  1.000 15.94598 ? 901  A1LV6 A C20 1 
HETATM 4303 C C21 . A1LV6 C 2 .   ? 16.99720  6.79797   33.36474  1.000 14.57546 ? 901  A1LV6 A C21 1 
HETATM 4304 C C22 . A1LV6 C 2 .   ? 18.28755  4.94701   33.15938  1.000 22.05492 ? 901  A1LV6 A C22 1 
HETATM 4305 C C24 . A1LV6 C 2 .   ? 19.41242  4.96450   35.23107  1.000 14.79691 ? 901  A1LV6 A C24 1 
HETATM 4306 C C26 . A1LV6 C 2 .   ? 21.03809  4.42731   31.97752  1.000 33.30761 ? 901  A1LV6 A C26 1 
HETATM 4307 C C1  . A1LV6 C 2 .   ? 15.27669  10.29604  36.61894  1.000 15.71817 ? 901  A1LV6 A C1  1 
HETATM 4308 C C11 . A1LV6 C 2 .   ? 21.26102  11.03676  34.79342  1.000 16.91009 ? 901  A1LV6 A C11 1 
HETATM 4309 C C12 . A1LV6 C 2 .   ? 23.55658  13.59311  35.68798  1.000 17.88852 ? 901  A1LV6 A C12 1 
HETATM 4310 C C14 . A1LV6 C 2 .   ? 21.77661  9.18254   33.11482  1.000 21.77565 ? 901  A1LV6 A C14 1 
HETATM 4311 C C16 . A1LV6 C 2 .   ? 21.10320  8.42483   31.96451  1.000 21.95733 ? 901  A1LV6 A C16 1 
HETATM 4312 C C18 . A1LV6 C 2 .   ? 16.06062  7.64699   34.28832  1.000 12.00676 ? 901  A1LV6 A C18 1 
HETATM 4313 C C19 . A1LV6 C 2 .   ? 14.71640  7.46346   34.59285  1.000 14.51708 ? 901  A1LV6 A C19 1 
HETATM 4314 C C2  . A1LV6 C 2 .   ? 14.13667  10.51933  37.38849  1.000 14.53896 ? 901  A1LV6 A C2  1 
HETATM 4315 C C23 . A1LV6 C 2 .   ? 19.48710  4.41392   33.90055  1.000 18.31161 ? 901  A1LV6 A C23 1 
HETATM 4316 C C25 . A1LV6 C 2 .   ? 18.50541  6.20636   35.14280  1.000 15.28634 ? 901  A1LV6 A C25 1 
HETATM 4317 C C3  . A1LV6 C 2 .   ? 14.18190  11.49237  38.33337  1.000 12.51971 ? 901  A1LV6 A C3  1 
HETATM 4318 C C9  . A1LV6 C 2 .   ? 19.72402  13.60207  37.66333  1.000 14.01658 ? 901  A1LV6 A C9  1 
HETATM 4319 N N2  . A1LV6 C 2 .   ? 15.34918  12.17255  38.51598  1.000 12.55639 ? 901  A1LV6 A N2  1 
HETATM 4320 N N4  . A1LV6 C 2 .   ? 20.97534  13.70201  37.12326  1.000 16.30342 ? 901  A1LV6 A N4  1 
HETATM 4321 N N5  . A1LV6 C 2 .   ? 22.38132  12.67953  35.51101  1.000 15.83863 ? 901  A1LV6 A N5  1 
HETATM 4322 N N6  . A1LV6 C 2 .   ? 15.35266  9.21544   35.68606  1.000 14.75969 ? 901  A1LV6 A N6  1 
HETATM 4323 N N7  . A1LV6 C 2 .   ? 14.26376  8.37203   35.47511  1.000 16.76557 ? 901  A1LV6 A N7  1 
HETATM 4324 N N8  . A1LV6 C 2 .   ? 17.56957  5.84812   34.07146  1.000 13.70227 ? 901  A1LV6 A N8  1 
HETATM 4325 O O1  . A1LV6 C 2 .   ? 19.65070  9.38126   34.27935  1.000 17.94748 ? 901  A1LV6 A O1  1 
HETATM 4326 O O2  . A1LV6 C 2 .   ? 20.68796  5.25479   35.85594  1.000 16.62704 ? 901  A1LV6 A O2  1 
HETATM 4327 O O3  . A1LV6 C 2 .   ? 20.73329  4.88414   33.29356  1.000 27.42274 ? 901  A1LV6 A O3  1 
HETATM 4328 N N1  . A1LV6 D 2 .   ? -3.37006  -31.83241 7.95063   1.000 11.72907 ? 901  A1LV6 B N1  1 
HETATM 4329 N N3  . A1LV6 D 2 .   ? -2.21133  -33.56277 6.77462   1.000 13.15542 ? 901  A1LV6 B N3  1 
HETATM 4330 C C4  . A1LV6 D 2 .   ? -3.38853  -32.81037 7.01957   1.000 13.57911 ? 901  A1LV6 B C4  1 
HETATM 4331 C C5  . A1LV6 D 2 .   ? -0.96783  -33.51027 7.46448   1.000 13.57825 ? 901  A1LV6 B C5  1 
HETATM 4332 C C6  . A1LV6 D 2 .   ? -0.64722  -32.56605 8.38748   1.000 13.34402 ? 901  A1LV6 B C6  1 
HETATM 4333 C C7  . A1LV6 D 2 .   ? 0.60602   -32.65441 8.95065   1.000 12.97609 ? 901  A1LV6 B C7  1 
HETATM 4334 C C8  . A1LV6 D 2 .   ? 1.46930   -33.73133 8.54640   1.000 15.29330 ? 901  A1LV6 B C8  1 
HETATM 4335 C C10 . A1LV6 D 2 .   ? 2.67411   -32.60246 10.02421  1.000 18.32064 ? 901  A1LV6 B C10 1 
HETATM 4336 C C13 . A1LV6 D 2 .   ? 0.97784   -30.71423 10.67001  1.000 18.51849 ? 901  A1LV6 B C13 1 
HETATM 4337 C C15 . A1LV6 D 2 .   ? 2.26120   -28.59382 11.46853  1.000 24.33165 ? 901  A1LV6 B C15 1 
HETATM 4338 C C17 . A1LV6 D 2 .   ? -3.37982  -29.68529 9.74416   1.000 13.06701 ? 901  A1LV6 B C17 1 
HETATM 4339 C C20 . A1LV6 D 2 .   ? -6.09484  -27.33442 10.61093  1.000 16.37002 ? 901  A1LV6 B C20 1 
HETATM 4340 C C21 . A1LV6 D 2 .   ? -2.80809  -27.71080 11.38420  1.000 14.31105 ? 901  A1LV6 B C21 1 
HETATM 4341 C C22 . A1LV6 D 2 .   ? -1.55392  -25.80691 11.56096  1.000 19.15766 ? 901  A1LV6 B C22 1 
HETATM 4342 C C24 . A1LV6 D 2 .   ? -0.42068  -25.83172 9.50526   1.000 14.20103 ? 901  A1LV6 B C24 1 
HETATM 4343 C C26 . A1LV6 D 2 .   ? 1.10108   -25.56248 12.80872  1.000 27.85205 ? 901  A1LV6 B C26 1 
HETATM 4344 C C1  . A1LV6 D 2 .   ? -4.50894  -31.19887 8.09184   1.000 15.08893 ? 901  A1LV6 B C1  1 
HETATM 4345 C C11 . A1LV6 D 2 .   ? 1.43876   -31.94117 9.93015   1.000 16.29379 ? 901  A1LV6 B C11 1 
HETATM 4346 C C12 . A1LV6 D 2 .   ? 3.72738   -34.50766 9.04144   1.000 17.15103 ? 901  A1LV6 B C12 1 
HETATM 4347 C C14 . A1LV6 D 2 .   ? 2.04518   -30.10494 11.58754  1.000 20.89723 ? 901  A1LV6 B C14 1 
HETATM 4348 C C16 . A1LV6 D 2 .   ? 1.43644   -29.16951 12.62068  1.000 19.24445 ? 901  A1LV6 B C16 1 
HETATM 4349 C C18 . A1LV6 D 2 .   ? -3.76673  -28.55999 10.47310  1.000 12.62658 ? 901  A1LV6 B C18 1 
HETATM 4350 C C19 . A1LV6 D 2 .   ? -5.11611  -28.40251 10.12660  1.000 13.79900 ? 901  A1LV6 B C19 1 
HETATM 4351 C C2  . A1LV6 D 2 .   ? -5.67804  -31.40563 7.36559   1.000 14.10250 ? 901  A1LV6 B C2  1 
HETATM 4352 C C23 . A1LV6 D 2 .   ? -0.34420  -25.29780 10.82600  1.000 17.09196 ? 901  A1LV6 B C23 1 
HETATM 4353 C C25 . A1LV6 D 2 .   ? -1.31505  -27.08434 9.58820   1.000 13.93187 ? 901  A1LV6 B C25 1 
HETATM 4354 C C3  . A1LV6 D 2 .   ? -5.63218  -32.40644 6.43355   1.000 12.65331 ? 901  A1LV6 B C3  1 
HETATM 4355 C C9  . A1LV6 D 2 .   ? -0.08983  -34.52133 7.08864   1.000 14.88691 ? 901  A1LV6 B C9  1 
HETATM 4356 N N2  . A1LV6 D 2 .   ? -4.46871  -33.06325 6.26017   1.000 13.21009 ? 901  A1LV6 B N2  1 
HETATM 4357 N N4  . A1LV6 D 2 .   ? 1.16832   -34.61860 7.63166   1.000 17.16393 ? 901  A1LV6 B N4  1 
HETATM 4358 N N5  . A1LV6 D 2 .   ? 2.56511   -33.58132 9.21172   1.000 15.75857 ? 901  A1LV6 B N5  1 
HETATM 4359 N N6  . A1LV6 D 2 .   ? -4.44304  -30.11443 9.02479   1.000 15.25984 ? 901  A1LV6 B N6  1 
HETATM 4360 N N7  . A1LV6 D 2 .   ? -5.55006  -29.31584 9.23895   1.000 15.35755 ? 901  A1LV6 B N7  1 
HETATM 4361 N N8  . A1LV6 D 2 .   ? -2.25698  -26.74653 10.67167  1.000 13.73690 ? 901  A1LV6 B N8  1 
HETATM 4362 O O1  . A1LV6 D 2 .   ? -0.15090  -30.29832 10.50303  1.000 17.62715 ? 901  A1LV6 B O1  1 
HETATM 4363 O O2  . A1LV6 D 2 .   ? 0.86220   -26.14624 8.91954   1.000 16.57392 ? 901  A1LV6 B O2  1 
HETATM 4364 O O3  . A1LV6 D 2 .   ? 0.85749   -25.87874 11.43413  1.000 24.13303 ? 901  A1LV6 B O3  1 
HETATM 4365 O O   . HOH   E 3 .   ? 35.79043  4.54665   49.27451  1.000 33.12427 ? 1001 HOH   A O   1 
HETATM 4366 O O   . HOH   E 3 .   ? 20.74553  -4.20094  64.99226  1.000 34.51227 ? 1002 HOH   A O   1 
HETATM 4367 O O   . HOH   E 3 .   ? 9.77031   11.89320  43.36076  1.000 17.82079 ? 1003 HOH   A O   1 
HETATM 4368 O O   . HOH   E 3 .   ? 7.62642   -9.38247  53.22841  1.000 29.15442 ? 1004 HOH   A O   1 
HETATM 4369 O O   . HOH   E 3 .   ? 30.08751  -6.59105  36.07175  1.000 26.63054 ? 1005 HOH   A O   1 
HETATM 4370 O O   . HOH   E 3 .   ? 17.375    26.098    34.646    1.000 33.67037 ? 1006 HOH   A O   1 
HETATM 4371 O O   . HOH   E 3 .   ? -0.01165  12.08531  31.77135  1.000 28.09282 ? 1007 HOH   A O   1 
HETATM 4372 O O   . HOH   E 3 .   ? 0.77909   16.70956  23.33352  1.000 30.25609 ? 1008 HOH   A O   1 
HETATM 4373 O O   . HOH   E 3 .   ? -0.416    3.265     47.477    1.000 27.23748 ? 1009 HOH   A O   1 
HETATM 4374 O O   . HOH   E 3 .   ? 5.16926   0.06759   53.50728  1.000 32.18656 ? 1010 HOH   A O   1 
HETATM 4375 O O   . HOH   E 3 .   ? 34.04171  3.82831   43.52357  1.000 30.99117 ? 1011 HOH   A O   1 
HETATM 4376 O O   . HOH   E 3 .   ? 20.17462  12.10842  57.67610  1.000 31.28066 ? 1012 HOH   A O   1 
HETATM 4377 O O   . HOH   E 3 .   ? 15.75740  -20.04247 43.35261  1.000 23.92838 ? 1013 HOH   A O   1 
HETATM 4378 O O   . HOH   E 3 .   ? 27.56071  -0.17686  41.07496  1.000 20.26681 ? 1014 HOH   A O   1 
HETATM 4379 O O   . HOH   E 3 .   ? 23.59290  5.11933   29.64951  1.000 38.44981 ? 1015 HOH   A O   1 
HETATM 4380 O O   . HOH   E 3 .   ? 1.84729   -0.07514  26.84208  1.000 30.26279 ? 1016 HOH   A O   1 
HETATM 4381 O O   . HOH   E 3 .   ? 22.73780  -13.54567 39.19417  1.000 16.77460 ? 1017 HOH   A O   1 
HETATM 4382 O O   . HOH   E 3 .   ? 7.64793   25.60826  31.91190  1.000 26.71235 ? 1018 HOH   A O   1 
HETATM 4383 O O   . HOH   E 3 .   ? 31.18283  1.88692   54.08602  1.000 26.98583 ? 1019 HOH   A O   1 
HETATM 4384 O O   . HOH   E 3 .   ? 21.49427  -22.02789 39.21985  1.000 27.15221 ? 1020 HOH   A O   1 
HETATM 4385 O O   . HOH   E 3 .   ? 20.860    20.921    39.639    1.000 18.30016 ? 1021 HOH   A O   1 
HETATM 4386 O O   . HOH   E 3 .   ? 23.88614  -0.51224  39.07472  1.000 15.22401 ? 1022 HOH   A O   1 
HETATM 4387 O O   . HOH   E 3 .   ? 25.00711  11.10445  32.24227  1.000 36.04776 ? 1023 HOH   A O   1 
HETATM 4388 O O   . HOH   E 3 .   ? 9.74530   7.40532   56.19400  1.000 33.57081 ? 1024 HOH   A O   1 
HETATM 4389 O O   . HOH   E 3 .   ? 19.61553  -18.58958 53.78366  1.000 28.45417 ? 1025 HOH   A O   1 
HETATM 4390 O O   . HOH   E 3 .   ? 9.42168   -4.27109  58.23185  1.000 24.04740 ? 1026 HOH   A O   1 
HETATM 4391 O O   . HOH   E 3 .   ? 10.22437  1.78351   29.16286  1.000 27.22402 ? 1027 HOH   A O   1 
HETATM 4392 O O   . HOH   E 3 .   ? 14.32791  -0.74074  34.03227  1.000 26.58893 ? 1028 HOH   A O   1 
HETATM 4393 O O   . HOH   E 3 .   ? 8.61843   -6.30235  44.77162  1.000 15.49725 ? 1029 HOH   A O   1 
HETATM 4394 O O   . HOH   E 3 .   ? 7.48860   -1.02334  30.30128  1.000 25.24507 ? 1030 HOH   A O   1 
HETATM 4395 O O   . HOH   E 3 .   ? 17.77606  15.07467  53.17284  1.000 27.43276 ? 1031 HOH   A O   1 
HETATM 4396 O O   . HOH   E 3 .   ? 12.13503  -1.94875  35.90685  1.000 16.20462 ? 1032 HOH   A O   1 
HETATM 4397 O O   . HOH   E 3 .   ? 17.04135  5.21608   56.64084  1.000 24.18824 ? 1033 HOH   A O   1 
HETATM 4398 O O   . HOH   E 3 .   ? -1.383    -2.455    43.663    1.000 26.49345 ? 1034 HOH   A O   1 
HETATM 4399 O O   . HOH   E 3 .   ? 3.36418   4.80118   50.80243  1.000 27.03046 ? 1035 HOH   A O   1 
HETATM 4400 O O   . HOH   E 3 .   ? 23.258    -14.379   56.456    1.000 24.62040 ? 1036 HOH   A O   1 
HETATM 4401 O O   . HOH   E 3 .   ? 1.568     33.945    46.791    1.000 21.63362 ? 1037 HOH   A O   1 
HETATM 4402 O O   . HOH   E 3 .   ? 34.22585  -0.47434  49.97373  1.000 20.78500 ? 1038 HOH   A O   1 
HETATM 4403 O O   . HOH   E 3 .   ? 10.19009  -15.75855 41.77254  1.000 26.71521 ? 1039 HOH   A O   1 
HETATM 4404 O O   . HOH   E 3 .   ? -5.513    -11.264   45.250    1.000 21.62602 ? 1040 HOH   A O   1 
HETATM 4405 O O   . HOH   E 3 .   ? 18.58204  0.88859   34.25692  1.000 28.88833 ? 1041 HOH   A O   1 
HETATM 4406 O O   . HOH   E 3 .   ? 1.065     -0.808    51.681    1.000 31.94733 ? 1042 HOH   A O   1 
HETATM 4407 O O   . HOH   E 3 .   ? 13.95606  -9.22489  60.08728  1.000 26.92958 ? 1043 HOH   A O   1 
HETATM 4408 O O   . HOH   E 3 .   ? 22.49502  -8.95485  59.85833  1.000 27.92525 ? 1044 HOH   A O   1 
HETATM 4409 O O   . HOH   E 3 .   ? 2.19409   -1.13675  33.05747  1.000 28.40346 ? 1045 HOH   A O   1 
HETATM 4410 O O   . HOH   E 3 .   ? 5.86345   -11.70422 45.03956  1.000 19.53307 ? 1046 HOH   A O   1 
HETATM 4411 O O   . HOH   E 3 .   ? 31.73433  -0.34506  52.86147  1.000 20.99895 ? 1047 HOH   A O   1 
HETATM 4412 O O   . HOH   E 3 .   ? 24.92425  10.66041  40.29186  1.000 17.61060 ? 1048 HOH   A O   1 
HETATM 4413 O O   . HOH   E 3 .   ? -1.449    -7.823    36.203    1.000 23.50387 ? 1049 HOH   A O   1 
HETATM 4414 O O   . HOH   E 3 .   ? 16.73513  16.48191  44.42841  1.000 19.29688 ? 1050 HOH   A O   1 
HETATM 4415 O O   . HOH   E 3 .   ? 33.92950  -4.34398  47.09559  1.000 18.67301 ? 1051 HOH   A O   1 
HETATM 4416 O O   . HOH   E 3 .   ? 13.09827  14.33084  43.92227  1.000 27.00221 ? 1052 HOH   A O   1 
HETATM 4417 O O   . HOH   E 3 .   ? 25.37143  15.06814  32.98061  1.000 34.13630 ? 1053 HOH   A O   1 
HETATM 4418 O O   . HOH   E 3 .   ? -0.22664  22.92553  35.73492  1.000 33.62266 ? 1054 HOH   A O   1 
HETATM 4419 O O   . HOH   E 3 .   ? 22.80770  15.23822  38.61879  1.000 26.74216 ? 1055 HOH   A O   1 
HETATM 4420 O O   . HOH   E 3 .   ? 11.27658  -9.57319  40.57256  1.000 21.78996 ? 1056 HOH   A O   1 
HETATM 4421 O O   . HOH   E 3 .   ? 24.86805  5.58094   36.60210  1.000 21.78703 ? 1057 HOH   A O   1 
HETATM 4422 O O   . HOH   E 3 .   ? 27.95225  -12.07283 29.74091  1.000 34.87138 ? 1058 HOH   A O   1 
HETATM 4423 O O   . HOH   E 3 .   ? 28.49596  10.77344  54.74915  1.000 22.05448 ? 1059 HOH   A O   1 
HETATM 4424 O O   . HOH   E 3 .   ? 15.08654  -6.77472  40.39252  1.000 18.17643 ? 1060 HOH   A O   1 
HETATM 4425 O O   . HOH   E 3 .   ? 23.51907  -12.09981 41.36414  1.000 14.76311 ? 1061 HOH   A O   1 
HETATM 4426 O O   . HOH   E 3 .   ? 7.72356   0.94228   53.60679  1.000 21.20463 ? 1062 HOH   A O   1 
HETATM 4427 O O   . HOH   E 3 .   ? 1.56090   -12.13285 37.65152  1.000 19.43702 ? 1063 HOH   A O   1 
HETATM 4428 O O   . HOH   E 3 .   ? 16.765    -25.944   39.251    1.000 23.42903 ? 1064 HOH   A O   1 
HETATM 4429 O O   . HOH   E 3 .   ? 5.66276   6.88162   42.08144  1.000 27.70364 ? 1065 HOH   A O   1 
HETATM 4430 O O   . HOH   E 3 .   ? 28.10117  0.72376   38.61369  1.000 24.17504 ? 1066 HOH   A O   1 
HETATM 4431 O O   . HOH   E 3 .   ? 0.189     -0.920    49.008    1.000 24.98549 ? 1067 HOH   A O   1 
HETATM 4432 O O   . HOH   E 3 .   ? 7.47331   -3.79686  32.13581  1.000 26.38091 ? 1068 HOH   A O   1 
HETATM 4433 O O   . HOH   E 3 .   ? 5.021     30.930    37.039    1.000 29.92517 ? 1069 HOH   A O   1 
HETATM 4434 O O   . HOH   E 3 .   ? 29.09450  -24.35283 38.84653  1.000 31.70601 ? 1070 HOH   A O   1 
HETATM 4435 O O   . HOH   E 3 .   ? 32.60068  8.08669   38.15084  1.000 34.69031 ? 1071 HOH   A O   1 
HETATM 4436 O O   . HOH   E 3 .   ? 35.94047  1.93375   50.13390  1.000 32.54400 ? 1072 HOH   A O   1 
HETATM 4437 O O   . HOH   E 3 .   ? 36.38097  -6.79739  53.58509  1.000 31.12685 ? 1073 HOH   A O   1 
HETATM 4438 O O   . HOH   E 3 .   ? 27.05475  -12.73834 45.37465  1.000 13.66254 ? 1074 HOH   A O   1 
HETATM 4439 O O   . HOH   E 3 .   ? 5.75211   7.50184   44.70243  1.000 20.38269 ? 1075 HOH   A O   1 
HETATM 4440 O O   . HOH   E 3 .   ? 7.41992   25.16097  25.83578  1.000 33.67302 ? 1076 HOH   A O   1 
HETATM 4441 O O   . HOH   E 3 .   ? 12.21495  6.59838   37.14775  1.000 20.22266 ? 1077 HOH   A O   1 
HETATM 4442 O O   . HOH   E 3 .   ? 31.83766  -5.38421  61.31592  1.000 29.25059 ? 1078 HOH   A O   1 
HETATM 4443 O O   . HOH   E 3 .   ? 3.88099   8.77723   40.54128  1.000 25.36278 ? 1079 HOH   A O   1 
HETATM 4444 O O   . HOH   E 3 .   ? 12.42378  -22.55778 47.16909  1.000 26.75647 ? 1080 HOH   A O   1 
HETATM 4445 O O   . HOH   E 3 .   ? 1.73673   -17.93990 42.93967  1.000 31.33033 ? 1081 HOH   A O   1 
HETATM 4446 O O   . HOH   E 3 .   ? 35.76598  10.77925  45.97338  1.000 27.41799 ? 1082 HOH   A O   1 
HETATM 4447 O O   . HOH   E 3 .   ? 23.08889  -16.06353 37.62126  1.000 29.65698 ? 1083 HOH   A O   1 
HETATM 4448 O O   . HOH   E 3 .   ? 9.26132   -10.47400 55.17774  1.000 21.89546 ? 1084 HOH   A O   1 
HETATM 4449 O O   . HOH   E 3 .   ? 15.73420  -24.84992 34.48384  1.000 28.99177 ? 1085 HOH   A O   1 
HETATM 4450 O O   . HOH   E 3 .   ? 2.18939   -5.00792  34.47978  1.000 22.43726 ? 1086 HOH   A O   1 
HETATM 4451 O O   . HOH   E 3 .   ? 16.23341  -11.03126 40.62951  1.000 17.44218 ? 1087 HOH   A O   1 
HETATM 4452 O O   . HOH   E 3 .   ? 32.90582  -7.08941  41.56866  1.000 21.44298 ? 1088 HOH   A O   1 
HETATM 4453 O O   . HOH   E 3 .   ? 7.78677   -11.46689 49.40889  1.000 28.61101 ? 1089 HOH   A O   1 
HETATM 4454 O O   . HOH   E 3 .   ? 17.10427  -6.81493  63.75479  1.000 29.39029 ? 1090 HOH   A O   1 
HETATM 4455 O O   . HOH   E 3 .   ? 14.932    -26.001   52.319    1.000 27.91262 ? 1091 HOH   A O   1 
HETATM 4456 O O   . HOH   E 3 .   ? 2.81305   -14.06580 34.63132  1.000 28.91850 ? 1092 HOH   A O   1 
HETATM 4457 O O   . HOH   E 3 .   ? 3.98447   -3.11070  33.29073  1.000 29.10513 ? 1093 HOH   A O   1 
HETATM 4458 O O   . HOH   E 3 .   ? 7.68214   3.91105   53.26586  1.000 25.52358 ? 1094 HOH   A O   1 
HETATM 4459 O O   . HOH   E 3 .   ? 2.96991   -8.13740  30.65854  1.000 34.17868 ? 1095 HOH   A O   1 
HETATM 4460 O O   . HOH   E 3 .   ? 25.60893  14.60937  41.54279  1.000 29.32706 ? 1096 HOH   A O   1 
HETATM 4461 O O   . HOH   E 3 .   ? 4.39377   -4.16610  30.72189  1.000 28.67284 ? 1097 HOH   A O   1 
HETATM 4462 O O   . HOH   E 3 .   ? 32.73013  5.39402   57.35715  1.000 32.74502 ? 1098 HOH   A O   1 
HETATM 4463 O O   . HOH   E 3 .   ? 25.58995  2.30918   35.47905  1.000 29.31830 ? 1099 HOH   A O   1 
HETATM 4464 O O   . HOH   E 3 .   ? 10.40799  -12.98998 55.22675  1.000 24.98519 ? 1100 HOH   A O   1 
HETATM 4465 O O   . HOH   E 3 .   ? 12.76124  -6.14733  65.82710  1.000 32.14983 ? 1101 HOH   A O   1 
HETATM 4466 O O   . HOH   E 3 .   ? 23.76912  9.07855   57.79987  1.000 33.32436 ? 1102 HOH   A O   1 
HETATM 4467 O O   . HOH   E 3 .   ? 27.39062  -15.38247 29.34621  1.000 34.12917 ? 1103 HOH   A O   1 
HETATM 4468 O O   . HOH   E 3 .   ? 29.81749  5.85081   59.70400  1.000 24.19339 ? 1104 HOH   A O   1 
HETATM 4469 O O   . HOH   E 3 .   ? 12.33548  12.44838  42.34536  1.000 22.18022 ? 1105 HOH   A O   1 
HETATM 4470 O O   . HOH   E 3 .   ? 33.24511  12.05718  49.37750  1.000 25.17596 ? 1106 HOH   A O   1 
HETATM 4471 O O   . HOH   E 3 .   ? 23.03898  -20.10969 39.50243  1.000 29.47845 ? 1107 HOH   A O   1 
HETATM 4472 O O   . HOH   E 3 .   ? 11.09985  23.42833  25.53938  1.000 21.69536 ? 1108 HOH   A O   1 
HETATM 4473 O O   . HOH   E 3 .   ? 25.30746  -0.48545  36.46881  1.000 24.87996 ? 1109 HOH   A O   1 
HETATM 4474 O O   . HOH   E 3 .   ? 35.40741  -2.70216  48.38886  1.000 28.47901 ? 1110 HOH   A O   1 
HETATM 4475 O O   . HOH   E 3 .   ? 7.56282   -12.94831 46.83455  1.000 18.63901 ? 1111 HOH   A O   1 
HETATM 4476 O O   . HOH   E 3 .   ? 11.31595  -8.89651  30.20850  1.000 34.18483 ? 1112 HOH   A O   1 
HETATM 4477 O O   . HOH   E 3 .   ? 32.73439  -5.80029  35.17465  1.000 26.79162 ? 1113 HOH   A O   1 
HETATM 4478 O O   . HOH   E 3 .   ? 15.85609  7.49416   56.81882  1.000 26.03477 ? 1114 HOH   A O   1 
HETATM 4479 O O   . HOH   E 3 .   ? 10.51527  2.96401   26.93453  1.000 34.50996 ? 1115 HOH   A O   1 
HETATM 4480 O O   . HOH   E 3 .   ? 24.19789  -8.03701  33.84686  1.000 14.37952 ? 1116 HOH   A O   1 
HETATM 4481 O O   . HOH   E 3 .   ? 24.58740  8.96383   30.45487  1.000 31.54316 ? 1117 HOH   A O   1 
HETATM 4482 O O   . HOH   E 3 .   ? 38.40033  1.41373   49.16589  1.000 30.20434 ? 1118 HOH   A O   1 
HETATM 4483 O O   . HOH   E 3 .   ? 13.65822  -9.56966  39.77701  1.000 27.53576 ? 1119 HOH   A O   1 
HETATM 4484 O O   . HOH   E 3 .   ? 34.48100  -7.43231  47.43988  1.000 31.48484 ? 1120 HOH   A O   1 
HETATM 4485 O O   . HOH   E 3 .   ? 34.78131  -4.98944  42.52188  1.000 29.20042 ? 1121 HOH   A O   1 
HETATM 4486 O O   . HOH   E 3 .   ? 4.94998   -2.70265  26.57793  1.000 32.51474 ? 1122 HOH   A O   1 
HETATM 4487 O O   . HOH   E 3 .   ? 15.87700  -21.76323 41.01828  1.000 26.24878 ? 1123 HOH   A O   1 
HETATM 4488 O O   . HOH   E 3 .   ? 9.39758   -8.65179  59.47385  1.000 29.99505 ? 1124 HOH   A O   1 
HETATM 4489 O O   . HOH   E 3 .   ? 27.57301  11.96708  40.73816  1.000 29.23265 ? 1125 HOH   A O   1 
HETATM 4490 O O   . HOH   E 3 .   ? -1.821    -2.501    47.682    1.000 27.88650 ? 1126 HOH   A O   1 
HETATM 4491 O O   . HOH   E 3 .   ? 26.18419  -10.32654 32.61553  1.000 31.39588 ? 1127 HOH   A O   1 
HETATM 4492 O O   . HOH   E 3 .   ? 27.99692  -4.63145  35.18314  1.000 25.63123 ? 1128 HOH   A O   1 
HETATM 4493 O O   . HOH   E 3 .   ? 25.09316  11.34386  37.56673  1.000 30.29016 ? 1129 HOH   A O   1 
HETATM 4494 O O   . HOH   E 3 .   ? 13.10070  11.19434  53.74129  1.000 36.70817 ? 1130 HOH   A O   1 
HETATM 4495 O O   . HOH   E 3 .   ? 14.97763  -12.24228 27.80370  1.000 41.35760 ? 1131 HOH   A O   1 
HETATM 4496 O O   . HOH   E 3 .   ? 27.65398  5.39693   35.97597  1.000 35.99690 ? 1132 HOH   A O   1 
HETATM 4497 O O   . HOH   E 3 .   ? 8.03583   -5.88597  59.88011  1.000 37.25050 ? 1133 HOH   A O   1 
HETATM 4498 O O   . HOH   E 3 .   ? 37.08338  -5.40966  35.57049  1.000 31.92206 ? 1134 HOH   A O   1 
HETATM 4499 O O   . HOH   E 3 .   ? 26.55877  10.28554  57.93268  1.000 34.76490 ? 1135 HOH   A O   1 
HETATM 4500 O O   . HOH   E 3 .   ? 21.47008  -13.41152 58.53222  1.000 28.78308 ? 1136 HOH   A O   1 
HETATM 4501 O O   . HOH   E 3 .   ? 8.63578   1.09296   56.22485  1.000 32.80384 ? 1137 HOH   A O   1 
HETATM 4502 O O   . HOH   E 3 .   ? 27.70917  -24.30851 35.84459  1.000 42.65152 ? 1138 HOH   A O   1 
HETATM 4503 O O   . HOH   E 3 .   ? 2.48197   -2.85835  26.89041  1.000 32.88732 ? 1139 HOH   A O   1 
HETATM 4504 O O   . HOH   E 3 .   ? 15.55082  -24.35079 42.35296  1.000 29.94899 ? 1140 HOH   A O   1 
HETATM 4505 O O   . HOH   E 3 .   ? 17.652    -25.717   36.553    1.000 30.04986 ? 1141 HOH   A O   1 
HETATM 4506 O O   . HOH   E 3 .   ? 16.89905  2.13189   30.71297  1.000 37.91311 ? 1142 HOH   A O   1 
HETATM 4507 O O   . HOH   E 3 .   ? 5.26193   -9.40453  54.51941  1.000 39.11169 ? 1143 HOH   A O   1 
HETATM 4508 O O   . HOH   E 3 .   ? 7.41083   -12.27482 51.75033  1.000 35.94794 ? 1144 HOH   A O   1 
HETATM 4509 O O   . HOH   E 3 .   ? 0.64675   -1.57845  30.99669  1.000 36.39527 ? 1145 HOH   A O   1 
HETATM 4510 O O   . HOH   E 3 .   ? 38.70592  -5.92093  52.52061  1.000 37.65765 ? 1146 HOH   A O   1 
HETATM 4511 O O   . HOH   E 3 .   ? 4.91278   -10.73974 48.94373  1.000 35.29507 ? 1147 HOH   A O   1 
HETATM 4512 O O   . HOH   E 3 .   ? 6.45756   -3.04278  28.89553  1.000 28.88419 ? 1148 HOH   A O   1 
HETATM 4513 O O   . HOH   E 3 .   ? -5.474    -8.831    44.436    1.000 28.63039 ? 1149 HOH   A O   1 
HETATM 4514 O O   . HOH   E 3 .   ? 26.48760  -6.18260  33.39757  1.000 29.53755 ? 1150 HOH   A O   1 
HETATM 4515 O O   . HOH   E 3 .   ? 1.43642   -11.72070 34.75345  1.000 29.36500 ? 1151 HOH   A O   1 
HETATM 4516 O O   . HOH   E 3 .   ? 19.01251  1.50587   29.73754  1.000 45.34758 ? 1152 HOH   A O   1 
HETATM 4517 O O   . HOH   F 3 .   ? -19.84006 -33.13178 12.84994  1.000 28.78961 ? 1001 HOH   B O   1 
HETATM 4518 O O   . HOH   F 3 .   ? -14.69825 -20.98667 -8.61299  1.000 31.79373 ? 1002 HOH   B O   1 
HETATM 4519 O O   . HOH   F 3 .   ? -22.66367 -44.17591 14.50320  1.000 38.86539 ? 1003 HOH   B O   1 
HETATM 4520 O O   . HOH   F 3 .   ? -4.02768  -0.86235  1.33429   1.000 24.26753 ? 1004 HOH   B O   1 
HETATM 4521 O O   . HOH   F 3 .   ? 0.33838   -32.94500 -12.90175 1.000 31.11349 ? 1005 HOH   B O   1 
HETATM 4522 O O   . HOH   F 3 .   ? 1.77975   1.17618   5.53513   1.000 26.04470 ? 1006 HOH   B O   1 
HETATM 4523 O O   . HOH   F 3 .   ? -5.09402  -47.83837 13.42333  1.000 32.25712 ? 1007 HOH   B O   1 
HETATM 4524 O O   . HOH   F 3 .   ? 14.33529  -24.67908 1.06865   1.000 31.74308 ? 1008 HOH   B O   1 
HETATM 4525 O O   . HOH   F 3 .   ? 10.32610  -14.35580 8.67709   1.000 25.50896 ? 1009 HOH   B O   1 
HETATM 4526 O O   . HOH   F 3 .   ? 5.21301   -32.07303 12.57556  1.000 34.18905 ? 1010 HOH   B O   1 
HETATM 4527 O O   . HOH   F 3 .   ? 7.80323   -20.73216 3.65106   1.000 19.76125 ? 1011 HOH   B O   1 
HETATM 4528 O O   . HOH   F 3 .   ? 11.46074  -22.81000 -9.39917  1.000 26.86476 ? 1012 HOH   B O   1 
HETATM 4529 O O   . HOH   F 3 .   ? -2.00689  -43.42795 4.82372   1.000 16.46827 ? 1013 HOH   B O   1 
HETATM 4530 O O   . HOH   F 3 .   ? 13.78887  -19.71681 6.07909   1.000 34.11914 ? 1014 HOH   B O   1 
HETATM 4531 O O   . HOH   F 3 .   ? 1.05426   -41.80086 5.06635   1.000 19.25454 ? 1015 HOH   B O   1 
HETATM 4532 O O   . HOH   F 3 .   ? 5.42145   -35.87889 11.77079  1.000 32.17097 ? 1016 HOH   B O   1 
HETATM 4533 O O   . HOH   F 3 .   ? -9.17208  -25.72886 9.17067   1.000 13.85160 ? 1017 HOH   B O   1 
HETATM 4534 O O   . HOH   F 3 .   ? -4.21470  -44.85672 5.47362   1.000 17.48901 ? 1018 HOH   B O   1 
HETATM 4535 O O   . HOH   F 3 .   ? 4.09883   -20.39151 5.70399   1.000 16.23117 ? 1019 HOH   B O   1 
HETATM 4536 O O   . HOH   F 3 .   ? -13.92792 -9.11123  -0.25064  1.000 20.84349 ? 1020 HOH   B O   1 
HETATM 4537 O O   . HOH   F 3 .   ? -18.62941 -20.15141 -6.91267  1.000 30.55412 ? 1021 HOH   B O   1 
HETATM 4538 O O   . HOH   F 3 .   ? -9.55695  -22.61955 15.54361  1.000 27.75981 ? 1022 HOH   B O   1 
HETATM 4539 O O   . HOH   F 3 .   ? -10.39334 -16.70305 -13.43007 1.000 23.94123 ? 1023 HOH   B O   1 
HETATM 4540 O O   . HOH   F 3 .   ? -11.17373 -14.60590 -0.04566  1.000 15.80639 ? 1024 HOH   B O   1 
HETATM 4541 O O   . HOH   F 3 .   ? 2.98332   -7.36611  5.56198   1.000 16.63251 ? 1025 HOH   B O   1 
HETATM 4542 O O   . HOH   F 3 .   ? -0.449    -2.272    -9.019    1.000 28.94352 ? 1026 HOH   B O   1 
HETATM 4543 O O   . HOH   F 3 .   ? -19.41869 -19.18763 9.17679   1.000 35.09670 ? 1027 HOH   B O   1 
HETATM 4544 O O   . HOH   F 3 .   ? -1.04658  -21.79699 10.42869  1.000 27.24821 ? 1028 HOH   B O   1 
HETATM 4545 O O   . HOH   F 3 .   ? -17.60132 -19.83706 11.79936  1.000 27.22556 ? 1029 HOH   B O   1 
HETATM 4546 O O   . HOH   F 3 .   ? -1.95627  -35.96896 -8.47704  1.000 27.30359 ? 1030 HOH   B O   1 
HETATM 4547 O O   . HOH   F 3 .   ? -18.00193 -20.76811 17.94234  1.000 30.76366 ? 1031 HOH   B O   1 
HETATM 4548 O O   . HOH   F 3 .   ? 11.97668  -20.63668 -8.05768  1.000 21.88293 ? 1032 HOH   B O   1 
HETATM 4549 O O   . HOH   F 3 .   ? -12.25279 -46.55023 12.78413  1.000 27.86219 ? 1033 HOH   B O   1 
HETATM 4550 O O   . HOH   F 3 .   ? -7.70823  -18.97165 8.83887   1.000 15.60840 ? 1034 HOH   B O   1 
HETATM 4551 O O   . HOH   F 3 .   ? -18.248   -54.833   -2.077    1.000 20.09231 ? 1035 HOH   B O   1 
HETATM 4552 O O   . HOH   F 3 .   ? -21.16463 -18.41463 1.10132   1.000 27.28200 ? 1036 HOH   B O   1 
HETATM 4553 O O   . HOH   F 3 .   ? 3.02489   -36.02688 5.97116   1.000 27.10029 ? 1037 HOH   B O   1 
HETATM 4554 O O   . HOH   F 3 .   ? -16.42545 -25.70248 -6.03475  1.000 27.53844 ? 1038 HOH   B O   1 
HETATM 4555 O O   . HOH   F 3 .   ? -2.75833  -26.12619 -11.83559 1.000 22.02726 ? 1039 HOH   B O   1 
HETATM 4556 O O   . HOH   F 3 .   ? 4.629     -4.975    -5.507    1.000 16.04945 ? 1040 HOH   B O   1 
HETATM 4557 O O   . HOH   F 3 .   ? -10.82564 0.90623   10.19854  1.000 32.82473 ? 1041 HOH   B O   1 
HETATM 4558 O O   . HOH   F 3 .   ? -12.35526 -19.94357 14.41569  1.000 24.28608 ? 1042 HOH   B O   1 
HETATM 4559 O O   . HOH   F 3 .   ? -9.67505  -5.09979  3.02772   1.000 24.84866 ? 1043 HOH   B O   1 
HETATM 4560 O O   . HOH   F 3 .   ? 5.13646   -31.61257 4.40150   1.000 17.08093 ? 1044 HOH   B O   1 
HETATM 4561 O O   . HOH   F 3 .   ? 14.37504  -20.42836 -5.21078  1.000 20.93591 ? 1045 HOH   B O   1 
HETATM 4562 O O   . HOH   F 3 .   ? 2.72905   -11.88810 -15.09852 1.000 27.62600 ? 1046 HOH   B O   1 
HETATM 4563 O O   . HOH   F 3 .   ? -26.64706 -2.31688  6.80330   1.000 28.50643 ? 1047 HOH   B O   1 
HETATM 4564 O O   . HOH   F 3 .   ? -25.25320 -9.59135  -0.52900  1.000 21.30227 ? 1048 HOH   B O   1 
HETATM 4565 O O   . HOH   F 3 .   ? -5.56637  -20.13059 10.73675  1.000 25.42405 ? 1049 HOH   B O   1 
HETATM 4566 O O   . HOH   F 3 .   ? 9.34807   3.38751   5.78915   1.000 33.52490 ? 1050 HOH   B O   1 
HETATM 4567 O O   . HOH   F 3 .   ? -19.59123 -20.00116 -4.22447  1.000 25.96694 ? 1051 HOH   B O   1 
HETATM 4568 O O   . HOH   F 3 .   ? -10.19720 -28.23495 -11.35971 1.000 33.11722 ? 1052 HOH   B O   1 
HETATM 4569 O O   . HOH   F 3 .   ? -21.22557 -13.04253 8.61846   1.000 23.52960 ? 1053 HOH   B O   1 
HETATM 4570 O O   . HOH   F 3 .   ? -17.91357 -3.06895  1.79986   1.000 32.26385 ? 1054 HOH   B O   1 
HETATM 4571 O O   . HOH   F 3 .   ? -3.06982  -37.40982 0.32874   1.000 17.95783 ? 1055 HOH   B O   1 
HETATM 4572 O O   . HOH   F 3 .   ? 3.40955   -25.68031 9.95187   1.000 25.59057 ? 1056 HOH   B O   1 
HETATM 4573 O O   . HOH   F 3 .   ? -4.78788  -14.13046 4.31297   1.000 16.90968 ? 1057 HOH   B O   1 
HETATM 4574 O O   . HOH   F 3 .   ? 3.405     -6.456    -11.673   1.000 24.74114 ? 1058 HOH   B O   1 
HETATM 4575 O O   . HOH   F 3 .   ? 16.61516  -14.24579 -8.65066  1.000 30.30173 ? 1059 HOH   B O   1 
HETATM 4576 O O   . HOH   F 3 .   ? 14.15677  -16.55213 -2.38248  1.000 20.43618 ? 1060 HOH   B O   1 
HETATM 4577 O O   . HOH   F 3 .   ? -5.83810  -11.76127 -15.43001 1.000 27.32650 ? 1061 HOH   B O   1 
HETATM 4578 O O   . HOH   F 3 .   ? 3.71767   -8.80726  3.38859   1.000 13.81522 ? 1062 HOH   B O   1 
HETATM 4579 O O   . HOH   F 3 .   ? 4.249     0.507     -1.705    1.000 19.28147 ? 1063 HOH   B O   1 
HETATM 4580 O O   . HOH   F 3 .   ? -6.77444  -35.16176 0.81357   1.000 25.68804 ? 1064 HOH   B O   1 
HETATM 4581 O O   . HOH   F 3 .   ? -12.04419 -21.85557 -8.87067  1.000 23.46249 ? 1065 HOH   B O   1 
HETATM 4582 O O   . HOH   F 3 .   ? -11.90622 -9.46807  -4.69174  1.000 27.65620 ? 1066 HOH   B O   1 
HETATM 4583 O O   . HOH   F 3 .   ? -14.12066 -27.77034 2.61975   1.000 26.02188 ? 1067 HOH   B O   1 
HETATM 4584 O O   . HOH   F 3 .   ? -15.92802 -29.61442 4.21864   1.000 25.95879 ? 1068 HOH   B O   1 
HETATM 4585 O O   . HOH   F 3 .   ? -4.66333  -25.13874 13.10433  1.000 20.54260 ? 1069 HOH   B O   1 
HETATM 4586 O O   . HOH   F 3 .   ? -7.46571  -33.33084 2.46292   1.000 22.42979 ? 1070 HOH   B O   1 
HETATM 4587 O O   . HOH   F 3 .   ? -19.98262 -43.56502 9.09938   1.000 35.17575 ? 1071 HOH   B O   1 
HETATM 4588 O O   . HOH   F 3 .   ? -17.64055 -15.90827 10.21444  1.000 23.40211 ? 1072 HOH   B O   1 
HETATM 4589 O O   . HOH   F 3 .   ? -18.27935 -8.74562  7.13428   1.000 19.41323 ? 1073 HOH   B O   1 
HETATM 4590 O O   . HOH   F 3 .   ? -16.78701 -12.71669 14.04461  1.000 39.07501 ? 1074 HOH   B O   1 
HETATM 4591 O O   . HOH   F 3 .   ? 13.14246  -13.86642 3.26783   1.000 21.89977 ? 1075 HOH   B O   1 
HETATM 4592 O O   . HOH   F 3 .   ? 5.10384   -26.55609 8.16509   1.000 24.23088 ? 1076 HOH   B O   1 
HETATM 4593 O O   . HOH   F 3 .   ? -15.21870 -11.52145 -1.39543  1.000 30.19269 ? 1077 HOH   B O   1 
HETATM 4594 O O   . HOH   F 3 .   ? 8.99429   -20.85197 -17.41020 1.000 35.19574 ? 1078 HOH   B O   1 
HETATM 4595 O O   . HOH   F 3 .   ? 15.94524  -13.56441 1.27786   1.000 32.38776 ? 1079 HOH   B O   1 
HETATM 4596 O O   . HOH   F 3 .   ? -12.32985 -17.06836 12.69028  1.000 25.61358 ? 1080 HOH   B O   1 
HETATM 4597 O O   . HOH   F 3 .   ? -8.54378  -11.38828 4.18620   1.000 20.26370 ? 1081 HOH   B O   1 
HETATM 4598 O O   . HOH   F 3 .   ? -2.97110  5.00174   5.53707   1.000 24.00678 ? 1082 HOH   B O   1 
HETATM 4599 O O   . HOH   F 3 .   ? -0.24196  -15.15228 -17.87598 1.000 28.22415 ? 1083 HOH   B O   1 
HETATM 4600 O O   . HOH   F 3 .   ? -14.04667 -28.45346 0.02597   1.000 20.37632 ? 1084 HOH   B O   1 
HETATM 4601 O O   . HOH   F 3 .   ? 15.91405  -31.79450 -1.25329  1.000 27.98758 ? 1085 HOH   B O   1 
HETATM 4602 O O   . HOH   F 3 .   ? 12.84898  -26.13057 -12.66158 1.000 31.48424 ? 1086 HOH   B O   1 
HETATM 4603 O O   . HOH   F 3 .   ? 8.32637   -21.60433 6.13596   1.000 22.94254 ? 1087 HOH   B O   1 
HETATM 4604 O O   . HOH   F 3 .   ? 11.96842  -15.49663 -16.69463 1.000 29.94441 ? 1088 HOH   B O   1 
HETATM 4605 O O   . HOH   F 3 .   ? -4.76312  3.01349   -0.08673  1.000 29.07792 ? 1089 HOH   B O   1 
HETATM 4606 O O   . HOH   F 3 .   ? -7.49245  -27.54044 7.56134   1.000 20.37032 ? 1090 HOH   B O   1 
HETATM 4607 O O   . HOH   F 3 .   ? 8.19777   -8.84663  15.09697  1.000 38.78411 ? 1091 HOH   B O   1 
HETATM 4608 O O   . HOH   F 3 .   ? 7.29194   -8.17042  -0.66859  1.000 13.97839 ? 1092 HOH   B O   1 
HETATM 4609 O O   . HOH   F 3 .   ? 13.45869  -32.89538 -4.69206  1.000 26.05615 ? 1093 HOH   B O   1 
HETATM 4610 O O   . HOH   F 3 .   ? -10.51504 -10.39217 -10.44779 1.000 22.16013 ? 1094 HOH   B O   1 
HETATM 4611 O O   . HOH   F 3 .   ? -6.80887  -23.13782 11.47405  1.000 24.35065 ? 1095 HOH   B O   1 
HETATM 4612 O O   . HOH   F 3 .   ? -15.81209 -17.65205 11.52312  1.000 29.52566 ? 1096 HOH   B O   1 
HETATM 4613 O O   . HOH   F 3 .   ? -16.97867 -6.79258  10.13068  1.000 27.78647 ? 1097 HOH   B O   1 
HETATM 4614 O O   . HOH   F 3 .   ? 15.56040  -18.08996 -3.75086  1.000 30.78300 ? 1098 HOH   B O   1 
HETATM 4615 O O   . HOH   F 3 .   ? -2.66945  -14.13005 -19.07669 1.000 30.17455 ? 1099 HOH   B O   1 
HETATM 4616 O O   . HOH   F 3 .   ? 10.05200  -26.77645 -14.88541 1.000 24.90439 ? 1100 HOH   B O   1 
HETATM 4617 O O   . HOH   F 3 .   ? -6.76125  -25.60587 -15.18153 1.000 36.08793 ? 1101 HOH   B O   1 
HETATM 4618 O O   . HOH   F 3 .   ? 5.76785   -35.56688 3.17405   1.000 29.42283 ? 1102 HOH   B O   1 
HETATM 4619 O O   . HOH   F 3 .   ? -9.44160  -7.81735  -10.40051 1.000 24.10510 ? 1103 HOH   B O   1 
HETATM 4620 O O   . HOH   F 3 .   ? -15.32010 -16.64822 14.08184  1.000 27.72345 ? 1104 HOH   B O   1 
HETATM 4621 O O   . HOH   F 3 .   ? 7.62350   -5.48438  15.46699  1.000 32.73245 ? 1105 HOH   B O   1 
HETATM 4622 O O   . HOH   F 3 .   ? 3.98797   -30.08770 -13.06856 1.000 31.30104 ? 1106 HOH   B O   1 
HETATM 4623 O O   . HOH   F 3 .   ? -12.14665 -24.78965 -8.65483  1.000 28.37658 ? 1107 HOH   B O   1 
HETATM 4624 O O   . HOH   F 3 .   ? 3.26884   -0.86989  5.24852   1.000 28.69355 ? 1108 HOH   B O   1 
HETATM 4625 O O   . HOH   F 3 .   ? -8.38154  -12.03534 14.46334  1.000 37.25501 ? 1109 HOH   B O   1 
HETATM 4626 O O   . HOH   F 3 .   ? -8.74112  -44.32522 19.21625  1.000 23.39826 ? 1110 HOH   B O   1 
HETATM 4627 O O   . HOH   F 3 .   ? -12.20578 -7.98170  -2.08157  1.000 19.04510 ? 1111 HOH   B O   1 
HETATM 4628 O O   . HOH   F 3 .   ? 5.62224   -23.27435 9.42296   1.000 30.02644 ? 1112 HOH   B O   1 
HETATM 4629 O O   . HOH   F 3 .   ? -8.40709  -8.10814  19.14893  1.000 42.27032 ? 1113 HOH   B O   1 
HETATM 4630 O O   . HOH   F 3 .   ? -3.98933  -28.42214 -12.07176 1.000 25.36455 ? 1114 HOH   B O   1 
HETATM 4631 O O   . HOH   F 3 .   ? -10.47170 -2.44570  2.68721   1.000 32.51416 ? 1115 HOH   B O   1 
HETATM 4632 O O   . HOH   F 3 .   ? 4.75063   -29.78441 14.28786  1.000 29.10188 ? 1116 HOH   B O   1 
HETATM 4633 O O   . HOH   F 3 .   ? 4.38647   -12.91964 10.89638  1.000 15.02792 ? 1117 HOH   B O   1 
HETATM 4634 O O   . HOH   F 3 .   ? -9.21216  -23.91320 17.82359  1.000 33.74868 ? 1118 HOH   B O   1 
HETATM 4635 O O   . HOH   F 3 .   ? 5.56061   -20.47155 8.26246   1.000 23.31171 ? 1119 HOH   B O   1 
HETATM 4636 O O   . HOH   F 3 .   ? -5.93465  -11.36740 5.04431   1.000 27.56240 ? 1120 HOH   B O   1 
HETATM 4637 O O   . HOH   F 3 .   ? -3.76188  0.85547   3.84045   1.000 26.62749 ? 1121 HOH   B O   1 
HETATM 4638 O O   . HOH   F 3 .   ? -10.38223 -12.10110 -14.66976 1.000 32.44898 ? 1122 HOH   B O   1 
HETATM 4639 O O   . HOH   F 3 .   ? 7.71774   -32.83998 4.01957   1.000 28.32689 ? 1123 HOH   B O   1 
HETATM 4640 O O   . HOH   F 3 .   ? 5.25045   -32.09676 7.29753   1.000 31.67032 ? 1124 HOH   B O   1 
HETATM 4641 O O   . HOH   F 3 .   ? -4.86027  -8.64734  16.96943  1.000 40.86915 ? 1125 HOH   B O   1 
HETATM 4642 O O   . HOH   F 3 .   ? -11.05291 -21.74714 -11.53440 1.000 33.26453 ? 1126 HOH   B O   1 
HETATM 4643 O O   . HOH   F 3 .   ? -18.07193 -13.17031 11.21629  1.000 34.14460 ? 1127 HOH   B O   1 
HETATM 4644 O O   . HOH   F 3 .   ? -4.49083  3.52297   2.34340   1.000 30.01240 ? 1128 HOH   B O   1 
HETATM 4645 O O   . HOH   F 3 .   ? -6.41408  -12.47743 -20.17575 1.000 40.20082 ? 1129 HOH   B O   1 
HETATM 4646 O O   . HOH   F 3 .   ? 6.66048   -31.28504 -13.06421 1.000 35.00686 ? 1130 HOH   B O   1 
HETATM 4647 O O   . HOH   F 3 .   ? -5.14720  -7.73902  -13.03711 1.000 35.64841 ? 1131 HOH   B O   1 
HETATM 4648 O O   . HOH   F 3 .   ? 0.60635   -41.78905 12.41667  1.000 32.81509 ? 1132 HOH   B O   1 
HETATM 4649 O O   . HOH   F 3 .   ? -2.21012  4.79382   8.20722   1.000 28.62975 ? 1133 HOH   B O   1 
HETATM 4650 O O   . HOH   F 3 .   ? 7.84434   3.30779   8.99202   1.000 41.04534 ? 1134 HOH   B O   1 
HETATM 4651 O O   . HOH   F 3 .   ? -2.97421  -23.10338 14.16663  1.000 34.51642 ? 1135 HOH   B O   1 
HETATM 4652 O O   . HOH   F 3 .   ? -19.18584 -19.21338 13.58697  1.000 34.72912 ? 1136 HOH   B O   1 
HETATM 4653 O O   . HOH   F 3 .   ? 18.670    -22.261   -4.498    1.000 30.16463 ? 1137 HOH   B O   1 
HETATM 4654 O O   . HOH   F 3 .   ? -14.51007 -11.38618 -9.90526  1.000 42.71289 ? 1138 HOH   B O   1 
HETATM 4655 O O   . HOH   F 3 .   ? -13.45888 -17.86706 15.83424  1.000 29.62777 ? 1139 HOH   B O   1 
HETATM 4656 O O   . HOH   F 3 .   ? -8.21137  -10.82503 -15.80317 1.000 36.32556 ? 1140 HOH   B O   1 
HETATM 4657 O O   . HOH   F 3 .   ? 8.23757   -16.26257 9.53130   1.000 25.44727 ? 1141 HOH   B O   1 
HETATM 4658 O O   . HOH   F 3 .   ? 5.17358   -29.60096 8.68555   1.000 31.00648 ? 1142 HOH   B O   1 
HETATM 4659 O O   . HOH   F 3 .   ? -17.70275 -17.14374 15.24477  1.000 31.66724 ? 1143 HOH   B O   1 
# 
