data_8XK7
# 
_entry.id   8XK7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8XK7         pdb_00008xk7 10.2210/pdb8xk7/pdb 
WWPDB D_1300043694 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8XK7 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wgong@ustc.edu.cn 
_pdbx_contact_author.name_first         Weimin 
_pdbx_contact_author.name_last          Gong 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6723-1298 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wen, C.'  1 ? 
'Liu, H.'  2 ? 
'Yang, L.' 3 ? 
'Gong, W.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Mol.Biol. 
_citation.journal_id_ASTM           JMOBAK 
_citation.journal_id_CSD            0070 
_citation.journal_id_ISSN           1089-8638 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            436 
_citation.language                  ? 
_citation.page_first                168744 
_citation.page_last                 168744 
_citation.title                     
;Structural Basis for C2'-methoxy Recognition by DNA Polymerases and Function Improvement.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.jmb.2024.168744 
_citation.pdbx_database_id_PubMed   39147125 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wen, C.'  1 ? 
primary 'Wang, G.' 2 ? 
primary 'Yang, L.' 3 ? 
primary 'Chen, T.' 4 ? 
primary 'Liu, H.'  5 ? 
primary 'Gong, W.' 6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'DNA polymerase I, thermostable'                                     62465.734 1   2.7.7.7 ? ? ? 
2 polymer     syn "DNA(5'-D(*AP*AP*AP*CP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*CP*OMG)-3')" 5283.424  1   ?       ? ? ? 
3 polymer     syn "DNA(5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*CP*OMG)-3')"             3992.602  1   ?       ? ? ? 
4 non-polymer syn 'PHOSPHATE ION'                                                      94.971    2   ?       ? ? ? 
5 non-polymer syn 'SULFATE ION'                                                        96.063    3   ?       ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                              106.120   1   ?       ? ? ? 
7 water       nat water                                                                18.015    346 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Taq polymerase 1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no  
;MEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDP
MLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDV
AYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAALEALREAHPIVEKIL
QYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQSIPVRTPLGQRIRRAFIAEEGWLLVALDYSQ
EGLRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVNPLMRRAAKTINFGVLYGMSAHRLSQKLAIPYEEAQAFI
ERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVRQAAERRAFNMPVQGTAADLMKLAMVKLFPRLE
EMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKEAAKLAAALEHHHHHH
;
;MEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDP
MLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDV
AYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAALEALREAHPIVEKIL
QYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQSIPVRTPLGQRIRRAFIAEEGWLLVALDYSQ
EGLRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVNPLMRRAAKTINFGVLYGMSAHRLSQKLAIPYEEAQAFI
ERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVRQAAERRAFNMPVQGTAADLMKLAMVKLFPRLE
EMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKEAAKLAAALEHHHHHH
;
A ? 
2 polydeoxyribonucleotide no yes '(DA)(DA)(DA)(DC)(DG)(DG)(DC)(DG)(DC)(DC)(DG)(DT)(DG)(DG)(DT)(DC)(OMG)' AAACGGCGCCGTGGTCG B ? 
3 polydeoxyribonucleotide no yes '(DG)(DA)(DC)(DC)(DA)(DC)(DG)(DG)(DC)(DG)(DC)(DC)(OMG)' GACCACGGCGCCG C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'PHOSPHATE ION'         PO4 
5 'SULFATE ION'           SO4 
6 'DI(HYDROXYETHYL)ETHER' PEG 
7 water                   HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   GLU n 
1 4   ALA n 
1 5   PRO n 
1 6   TRP n 
1 7   PRO n 
1 8   PRO n 
1 9   PRO n 
1 10  GLU n 
1 11  GLY n 
1 12  ALA n 
1 13  PHE n 
1 14  VAL n 
1 15  GLY n 
1 16  PHE n 
1 17  VAL n 
1 18  LEU n 
1 19  SER n 
1 20  ARG n 
1 21  LYS n 
1 22  GLU n 
1 23  PRO n 
1 24  MET n 
1 25  TRP n 
1 26  ALA n 
1 27  ASP n 
1 28  LEU n 
1 29  LEU n 
1 30  ALA n 
1 31  LEU n 
1 32  ALA n 
1 33  ALA n 
1 34  ALA n 
1 35  ARG n 
1 36  GLY n 
1 37  GLY n 
1 38  ARG n 
1 39  VAL n 
1 40  HIS n 
1 41  ARG n 
1 42  ALA n 
1 43  PRO n 
1 44  GLU n 
1 45  PRO n 
1 46  TYR n 
1 47  LYS n 
1 48  ALA n 
1 49  LEU n 
1 50  ARG n 
1 51  ASP n 
1 52  LEU n 
1 53  LYS n 
1 54  GLU n 
1 55  ALA n 
1 56  ARG n 
1 57  GLY n 
1 58  LEU n 
1 59  LEU n 
1 60  ALA n 
1 61  LYS n 
1 62  ASP n 
1 63  LEU n 
1 64  SER n 
1 65  VAL n 
1 66  LEU n 
1 67  ALA n 
1 68  LEU n 
1 69  ARG n 
1 70  GLU n 
1 71  GLY n 
1 72  LEU n 
1 73  GLY n 
1 74  LEU n 
1 75  PRO n 
1 76  PRO n 
1 77  GLY n 
1 78  ASP n 
1 79  ASP n 
1 80  PRO n 
1 81  MET n 
1 82  LEU n 
1 83  LEU n 
1 84  ALA n 
1 85  TYR n 
1 86  LEU n 
1 87  LEU n 
1 88  ASP n 
1 89  PRO n 
1 90  SER n 
1 91  ASN n 
1 92  THR n 
1 93  THR n 
1 94  PRO n 
1 95  GLU n 
1 96  GLY n 
1 97  VAL n 
1 98  ALA n 
1 99  ARG n 
1 100 ARG n 
1 101 TYR n 
1 102 GLY n 
1 103 GLY n 
1 104 GLU n 
1 105 TRP n 
1 106 THR n 
1 107 GLU n 
1 108 GLU n 
1 109 ALA n 
1 110 GLY n 
1 111 GLU n 
1 112 ARG n 
1 113 ALA n 
1 114 ALA n 
1 115 LEU n 
1 116 SER n 
1 117 GLU n 
1 118 ARG n 
1 119 LEU n 
1 120 PHE n 
1 121 ALA n 
1 122 ASN n 
1 123 LEU n 
1 124 TRP n 
1 125 GLY n 
1 126 ARG n 
1 127 LEU n 
1 128 GLU n 
1 129 GLY n 
1 130 GLU n 
1 131 GLU n 
1 132 ARG n 
1 133 LEU n 
1 134 LEU n 
1 135 TRP n 
1 136 LEU n 
1 137 TYR n 
1 138 ARG n 
1 139 GLU n 
1 140 VAL n 
1 141 GLU n 
1 142 ARG n 
1 143 PRO n 
1 144 LEU n 
1 145 SER n 
1 146 ALA n 
1 147 VAL n 
1 148 LEU n 
1 149 ALA n 
1 150 HIS n 
1 151 MET n 
1 152 GLU n 
1 153 ALA n 
1 154 THR n 
1 155 GLY n 
1 156 VAL n 
1 157 ARG n 
1 158 LEU n 
1 159 ASP n 
1 160 VAL n 
1 161 ALA n 
1 162 TYR n 
1 163 LEU n 
1 164 ARG n 
1 165 ALA n 
1 166 LEU n 
1 167 SER n 
1 168 LEU n 
1 169 GLU n 
1 170 VAL n 
1 171 ALA n 
1 172 GLU n 
1 173 GLU n 
1 174 ILE n 
1 175 ALA n 
1 176 ARG n 
1 177 LEU n 
1 178 GLU n 
1 179 ALA n 
1 180 GLU n 
1 181 VAL n 
1 182 PHE n 
1 183 ARG n 
1 184 LEU n 
1 185 ALA n 
1 186 GLY n 
1 187 HIS n 
1 188 PRO n 
1 189 PHE n 
1 190 ASN n 
1 191 LEU n 
1 192 ASN n 
1 193 SER n 
1 194 ARG n 
1 195 ASP n 
1 196 GLN n 
1 197 LEU n 
1 198 GLU n 
1 199 ARG n 
1 200 VAL n 
1 201 LEU n 
1 202 PHE n 
1 203 ASP n 
1 204 GLU n 
1 205 LEU n 
1 206 GLY n 
1 207 LEU n 
1 208 PRO n 
1 209 ALA n 
1 210 ILE n 
1 211 GLY n 
1 212 LYS n 
1 213 THR n 
1 214 GLU n 
1 215 LYS n 
1 216 THR n 
1 217 GLY n 
1 218 LYS n 
1 219 ARG n 
1 220 SER n 
1 221 THR n 
1 222 SER n 
1 223 ALA n 
1 224 ALA n 
1 225 ALA n 
1 226 LEU n 
1 227 GLU n 
1 228 ALA n 
1 229 LEU n 
1 230 ARG n 
1 231 GLU n 
1 232 ALA n 
1 233 HIS n 
1 234 PRO n 
1 235 ILE n 
1 236 VAL n 
1 237 GLU n 
1 238 LYS n 
1 239 ILE n 
1 240 LEU n 
1 241 GLN n 
1 242 TYR n 
1 243 ARG n 
1 244 GLU n 
1 245 LEU n 
1 246 THR n 
1 247 LYS n 
1 248 LEU n 
1 249 LYS n 
1 250 SER n 
1 251 THR n 
1 252 TYR n 
1 253 ILE n 
1 254 ASP n 
1 255 PRO n 
1 256 LEU n 
1 257 PRO n 
1 258 ASP n 
1 259 LEU n 
1 260 ILE n 
1 261 HIS n 
1 262 PRO n 
1 263 ARG n 
1 264 THR n 
1 265 GLY n 
1 266 ARG n 
1 267 LEU n 
1 268 HIS n 
1 269 THR n 
1 270 ARG n 
1 271 PHE n 
1 272 ASN n 
1 273 GLN n 
1 274 THR n 
1 275 ALA n 
1 276 THR n 
1 277 ALA n 
1 278 THR n 
1 279 GLY n 
1 280 ARG n 
1 281 LEU n 
1 282 SER n 
1 283 SER n 
1 284 SER n 
1 285 ASP n 
1 286 PRO n 
1 287 ASN n 
1 288 LEU n 
1 289 GLN n 
1 290 SER n 
1 291 ILE n 
1 292 PRO n 
1 293 VAL n 
1 294 ARG n 
1 295 THR n 
1 296 PRO n 
1 297 LEU n 
1 298 GLY n 
1 299 GLN n 
1 300 ARG n 
1 301 ILE n 
1 302 ARG n 
1 303 ARG n 
1 304 ALA n 
1 305 PHE n 
1 306 ILE n 
1 307 ALA n 
1 308 GLU n 
1 309 GLU n 
1 310 GLY n 
1 311 TRP n 
1 312 LEU n 
1 313 LEU n 
1 314 VAL n 
1 315 ALA n 
1 316 LEU n 
1 317 ASP n 
1 318 TYR n 
1 319 SER n 
1 320 GLN n 
1 321 GLU n 
1 322 GLY n 
1 323 LEU n 
1 324 ARG n 
1 325 VAL n 
1 326 LEU n 
1 327 ALA n 
1 328 HIS n 
1 329 LEU n 
1 330 SER n 
1 331 GLY n 
1 332 ASP n 
1 333 GLU n 
1 334 ASN n 
1 335 LEU n 
1 336 ILE n 
1 337 ARG n 
1 338 VAL n 
1 339 PHE n 
1 340 GLN n 
1 341 GLU n 
1 342 GLY n 
1 343 ARG n 
1 344 ASP n 
1 345 ILE n 
1 346 HIS n 
1 347 THR n 
1 348 GLU n 
1 349 THR n 
1 350 ALA n 
1 351 SER n 
1 352 TRP n 
1 353 MET n 
1 354 PHE n 
1 355 GLY n 
1 356 VAL n 
1 357 PRO n 
1 358 ARG n 
1 359 GLU n 
1 360 ALA n 
1 361 VAL n 
1 362 ASN n 
1 363 PRO n 
1 364 LEU n 
1 365 MET n 
1 366 ARG n 
1 367 ARG n 
1 368 ALA n 
1 369 ALA n 
1 370 LYS n 
1 371 THR n 
1 372 ILE n 
1 373 ASN n 
1 374 PHE n 
1 375 GLY n 
1 376 VAL n 
1 377 LEU n 
1 378 TYR n 
1 379 GLY n 
1 380 MET n 
1 381 SER n 
1 382 ALA n 
1 383 HIS n 
1 384 ARG n 
1 385 LEU n 
1 386 SER n 
1 387 GLN n 
1 388 LYS n 
1 389 LEU n 
1 390 ALA n 
1 391 ILE n 
1 392 PRO n 
1 393 TYR n 
1 394 GLU n 
1 395 GLU n 
1 396 ALA n 
1 397 GLN n 
1 398 ALA n 
1 399 PHE n 
1 400 ILE n 
1 401 GLU n 
1 402 ARG n 
1 403 TYR n 
1 404 PHE n 
1 405 GLN n 
1 406 SER n 
1 407 PHE n 
1 408 PRO n 
1 409 LYS n 
1 410 VAL n 
1 411 ARG n 
1 412 ALA n 
1 413 TRP n 
1 414 ILE n 
1 415 GLU n 
1 416 LYS n 
1 417 THR n 
1 418 LEU n 
1 419 GLU n 
1 420 GLU n 
1 421 GLY n 
1 422 ARG n 
1 423 ARG n 
1 424 ARG n 
1 425 GLY n 
1 426 TYR n 
1 427 VAL n 
1 428 GLU n 
1 429 THR n 
1 430 LEU n 
1 431 PHE n 
1 432 GLY n 
1 433 ARG n 
1 434 ARG n 
1 435 ARG n 
1 436 TYR n 
1 437 VAL n 
1 438 PRO n 
1 439 ASP n 
1 440 LEU n 
1 441 GLU n 
1 442 ALA n 
1 443 ARG n 
1 444 VAL n 
1 445 LYS n 
1 446 SER n 
1 447 VAL n 
1 448 ARG n 
1 449 GLN n 
1 450 ALA n 
1 451 ALA n 
1 452 GLU n 
1 453 ARG n 
1 454 ARG n 
1 455 ALA n 
1 456 PHE n 
1 457 ASN n 
1 458 MET n 
1 459 PRO n 
1 460 VAL n 
1 461 GLN n 
1 462 GLY n 
1 463 THR n 
1 464 ALA n 
1 465 ALA n 
1 466 ASP n 
1 467 LEU n 
1 468 MET n 
1 469 LYS n 
1 470 LEU n 
1 471 ALA n 
1 472 MET n 
1 473 VAL n 
1 474 LYS n 
1 475 LEU n 
1 476 PHE n 
1 477 PRO n 
1 478 ARG n 
1 479 LEU n 
1 480 GLU n 
1 481 GLU n 
1 482 MET n 
1 483 GLY n 
1 484 ALA n 
1 485 ARG n 
1 486 MET n 
1 487 LEU n 
1 488 LEU n 
1 489 GLN n 
1 490 VAL n 
1 491 HIS n 
1 492 ASP n 
1 493 GLU n 
1 494 LEU n 
1 495 VAL n 
1 496 LEU n 
1 497 GLU n 
1 498 ALA n 
1 499 PRO n 
1 500 LYS n 
1 501 GLU n 
1 502 ARG n 
1 503 ALA n 
1 504 GLU n 
1 505 ALA n 
1 506 VAL n 
1 507 ALA n 
1 508 ARG n 
1 509 LEU n 
1 510 ALA n 
1 511 LYS n 
1 512 GLU n 
1 513 VAL n 
1 514 MET n 
1 515 GLU n 
1 516 GLY n 
1 517 VAL n 
1 518 TYR n 
1 519 PRO n 
1 520 LEU n 
1 521 ALA n 
1 522 VAL n 
1 523 PRO n 
1 524 LEU n 
1 525 GLU n 
1 526 VAL n 
1 527 GLU n 
1 528 VAL n 
1 529 GLY n 
1 530 ILE n 
1 531 GLY n 
1 532 GLU n 
1 533 ASP n 
1 534 TRP n 
1 535 LEU n 
1 536 SER n 
1 537 ALA n 
1 538 LYS n 
1 539 GLU n 
1 540 ALA n 
1 541 ALA n 
1 542 LYS n 
1 543 LEU n 
1 544 ALA n 
1 545 ALA n 
1 546 ALA n 
1 547 LEU n 
1 548 GLU n 
1 549 HIS n 
1 550 HIS n 
1 551 HIS n 
1 552 HIS n 
1 553 HIS n 
1 554 HIS n 
2 1   DA  n 
2 2   DA  n 
2 3   DA  n 
2 4   DC  n 
2 5   DG  n 
2 6   DG  n 
2 7   DC  n 
2 8   DG  n 
2 9   DC  n 
2 10  DC  n 
2 11  DG  n 
2 12  DT  n 
2 13  DG  n 
2 14  DG  n 
2 15  DT  n 
2 16  DC  n 
2 17  OMG n 
3 1   DG  n 
3 2   DA  n 
3 3   DC  n 
3 4   DC  n 
3 5   DA  n 
3 6   DC  n 
3 7   DG  n 
3 8   DG  n 
3 9   DC  n 
3 10  DG  n 
3 11  DC  n 
3 12  DC  n 
3 13  OMG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   554 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'polA, pol1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Thermus aquaticus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     271 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_src_syn.entity_id 
_pdbx_entity_src_syn.pdbx_src_id 
_pdbx_entity_src_syn.pdbx_alt_source_flag 
_pdbx_entity_src_syn.pdbx_beg_seq_num 
_pdbx_entity_src_syn.pdbx_end_seq_num 
_pdbx_entity_src_syn.organism_scientific 
_pdbx_entity_src_syn.organism_common_name 
_pdbx_entity_src_syn.ncbi_taxonomy_id 
_pdbx_entity_src_syn.details 
2 1 sample 1 17 'synthetic construct' ? 32630 ? 
3 1 sample 1 13 'synthetic construct' ? 32630 ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                               ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ? 'C4 H7 N O4'      133.103 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE"   ? 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"    ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE"   ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"           ? 'C10 H15 N2 O8 P' 322.208 
GLN 'L-peptide linking' y GLUTAMINE                              ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                              ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                  ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                             ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                 ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                             ? 'C5 H11 N O2 S'   149.211 
OMG 'RNA linking'       n "O2'-METHYLGUANOSINE-5'-MONOPHOSPHATE" ? 'C11 H16 N5 O8 P' 377.247 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                ? 'C4 H10 O3'       106.120 
PHE 'L-peptide linking' y PHENYLALANINE                          ? 'C9 H11 N O2'     165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                        ? 'O4 P -3'         94.971  
PRO 'L-peptide linking' y PROLINE                                ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                 ? 'C3 H7 N O3'      105.093 
SO4 non-polymer         . 'SULFATE ION'                          ? 'O4 S -2'         96.063  
THR 'L-peptide linking' y THREONINE                              ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                               ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                 ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   294 ?   ?   ?   A . n 
A 1 2   GLU 2   295 ?   ?   ?   A . n 
A 1 3   GLU 3   296 296 GLU GLU A . n 
A 1 4   ALA 4   297 297 ALA ALA A . n 
A 1 5   PRO 5   298 298 PRO PRO A . n 
A 1 6   TRP 6   299 299 TRP TRP A . n 
A 1 7   PRO 7   300 300 PRO PRO A . n 
A 1 8   PRO 8   301 301 PRO PRO A . n 
A 1 9   PRO 9   302 302 PRO PRO A . n 
A 1 10  GLU 10  303 303 GLU GLU A . n 
A 1 11  GLY 11  304 304 GLY GLY A . n 
A 1 12  ALA 12  305 305 ALA ALA A . n 
A 1 13  PHE 13  306 306 PHE PHE A . n 
A 1 14  VAL 14  307 307 VAL VAL A . n 
A 1 15  GLY 15  308 308 GLY GLY A . n 
A 1 16  PHE 16  309 309 PHE PHE A . n 
A 1 17  VAL 17  310 310 VAL VAL A . n 
A 1 18  LEU 18  311 311 LEU LEU A . n 
A 1 19  SER 19  312 312 SER SER A . n 
A 1 20  ARG 20  313 313 ARG ARG A . n 
A 1 21  LYS 21  314 314 LYS LYS A . n 
A 1 22  GLU 22  315 315 GLU GLU A . n 
A 1 23  PRO 23  316 316 PRO PRO A . n 
A 1 24  MET 24  317 317 MET MET A . n 
A 1 25  TRP 25  318 318 TRP TRP A . n 
A 1 26  ALA 26  319 319 ALA ALA A . n 
A 1 27  ASP 27  320 320 ASP ASP A . n 
A 1 28  LEU 28  321 321 LEU LEU A . n 
A 1 29  LEU 29  322 322 LEU LEU A . n 
A 1 30  ALA 30  323 323 ALA ALA A . n 
A 1 31  LEU 31  324 324 LEU LEU A . n 
A 1 32  ALA 32  325 325 ALA ALA A . n 
A 1 33  ALA 33  326 326 ALA ALA A . n 
A 1 34  ALA 34  327 327 ALA ALA A . n 
A 1 35  ARG 35  328 328 ARG ARG A . n 
A 1 36  GLY 36  329 329 GLY GLY A . n 
A 1 37  GLY 37  330 330 GLY GLY A . n 
A 1 38  ARG 38  331 331 ARG ARG A . n 
A 1 39  VAL 39  332 332 VAL VAL A . n 
A 1 40  HIS 40  333 333 HIS HIS A . n 
A 1 41  ARG 41  334 334 ARG ARG A . n 
A 1 42  ALA 42  335 335 ALA ALA A . n 
A 1 43  PRO 43  336 336 PRO PRO A . n 
A 1 44  GLU 44  337 337 GLU GLU A . n 
A 1 45  PRO 45  338 338 PRO PRO A . n 
A 1 46  TYR 46  339 339 TYR TYR A . n 
A 1 47  LYS 47  340 340 LYS LYS A . n 
A 1 48  ALA 48  341 341 ALA ALA A . n 
A 1 49  LEU 49  342 342 LEU LEU A . n 
A 1 50  ARG 50  343 343 ARG ARG A . n 
A 1 51  ASP 51  344 344 ASP ASP A . n 
A 1 52  LEU 52  345 345 LEU LEU A . n 
A 1 53  LYS 53  346 346 LYS LYS A . n 
A 1 54  GLU 54  347 347 GLU GLU A . n 
A 1 55  ALA 55  348 348 ALA ALA A . n 
A 1 56  ARG 56  349 349 ARG ARG A . n 
A 1 57  GLY 57  350 350 GLY GLY A . n 
A 1 58  LEU 58  351 351 LEU LEU A . n 
A 1 59  LEU 59  352 352 LEU LEU A . n 
A 1 60  ALA 60  353 353 ALA ALA A . n 
A 1 61  LYS 61  354 354 LYS LYS A . n 
A 1 62  ASP 62  355 355 ASP ASP A . n 
A 1 63  LEU 63  356 356 LEU LEU A . n 
A 1 64  SER 64  357 357 SER SER A . n 
A 1 65  VAL 65  358 358 VAL VAL A . n 
A 1 66  LEU 66  359 359 LEU LEU A . n 
A 1 67  ALA 67  360 360 ALA ALA A . n 
A 1 68  LEU 68  361 361 LEU LEU A . n 
A 1 69  ARG 69  362 362 ARG ARG A . n 
A 1 70  GLU 70  363 363 GLU GLU A . n 
A 1 71  GLY 71  364 364 GLY GLY A . n 
A 1 72  LEU 72  365 365 LEU LEU A . n 
A 1 73  GLY 73  366 366 GLY GLY A . n 
A 1 74  LEU 74  367 367 LEU LEU A . n 
A 1 75  PRO 75  368 368 PRO PRO A . n 
A 1 76  PRO 76  369 369 PRO PRO A . n 
A 1 77  GLY 77  370 370 GLY GLY A . n 
A 1 78  ASP 78  371 371 ASP ASP A . n 
A 1 79  ASP 79  372 372 ASP ASP A . n 
A 1 80  PRO 80  373 373 PRO PRO A . n 
A 1 81  MET 81  374 374 MET MET A . n 
A 1 82  LEU 82  375 375 LEU LEU A . n 
A 1 83  LEU 83  376 376 LEU LEU A . n 
A 1 84  ALA 84  377 377 ALA ALA A . n 
A 1 85  TYR 85  378 378 TYR TYR A . n 
A 1 86  LEU 86  379 379 LEU LEU A . n 
A 1 87  LEU 87  380 380 LEU LEU A . n 
A 1 88  ASP 88  381 381 ASP ASP A . n 
A 1 89  PRO 89  382 382 PRO PRO A . n 
A 1 90  SER 90  383 383 SER SER A . n 
A 1 91  ASN 91  384 384 ASN ASN A . n 
A 1 92  THR 92  385 385 THR THR A . n 
A 1 93  THR 93  386 386 THR THR A . n 
A 1 94  PRO 94  387 387 PRO PRO A . n 
A 1 95  GLU 95  388 388 GLU GLU A . n 
A 1 96  GLY 96  389 389 GLY GLY A . n 
A 1 97  VAL 97  390 390 VAL VAL A . n 
A 1 98  ALA 98  391 391 ALA ALA A . n 
A 1 99  ARG 99  392 392 ARG ARG A . n 
A 1 100 ARG 100 393 393 ARG ARG A . n 
A 1 101 TYR 101 394 394 TYR TYR A . n 
A 1 102 GLY 102 395 395 GLY GLY A . n 
A 1 103 GLY 103 396 396 GLY GLY A . n 
A 1 104 GLU 104 397 397 GLU GLU A . n 
A 1 105 TRP 105 398 398 TRP TRP A . n 
A 1 106 THR 106 399 399 THR THR A . n 
A 1 107 GLU 107 400 400 GLU GLU A . n 
A 1 108 GLU 108 401 401 GLU GLU A . n 
A 1 109 ALA 109 402 402 ALA ALA A . n 
A 1 110 GLY 110 403 403 GLY GLY A . n 
A 1 111 GLU 111 404 404 GLU GLU A . n 
A 1 112 ARG 112 405 405 ARG ARG A . n 
A 1 113 ALA 113 406 406 ALA ALA A . n 
A 1 114 ALA 114 407 407 ALA ALA A . n 
A 1 115 LEU 115 408 408 LEU LEU A . n 
A 1 116 SER 116 409 409 SER SER A . n 
A 1 117 GLU 117 410 410 GLU GLU A . n 
A 1 118 ARG 118 411 411 ARG ARG A . n 
A 1 119 LEU 119 412 412 LEU LEU A . n 
A 1 120 PHE 120 413 413 PHE PHE A . n 
A 1 121 ALA 121 414 414 ALA ALA A . n 
A 1 122 ASN 122 415 415 ASN ASN A . n 
A 1 123 LEU 123 416 416 LEU LEU A . n 
A 1 124 TRP 124 417 417 TRP TRP A . n 
A 1 125 GLY 125 418 418 GLY GLY A . n 
A 1 126 ARG 126 419 419 ARG ARG A . n 
A 1 127 LEU 127 420 420 LEU LEU A . n 
A 1 128 GLU 128 421 421 GLU GLU A . n 
A 1 129 GLY 129 422 422 GLY GLY A . n 
A 1 130 GLU 130 423 423 GLU GLU A . n 
A 1 131 GLU 131 424 424 GLU GLU A . n 
A 1 132 ARG 132 425 425 ARG ARG A . n 
A 1 133 LEU 133 426 426 LEU LEU A . n 
A 1 134 LEU 134 427 427 LEU LEU A . n 
A 1 135 TRP 135 428 428 TRP TRP A . n 
A 1 136 LEU 136 429 429 LEU LEU A . n 
A 1 137 TYR 137 430 430 TYR TYR A . n 
A 1 138 ARG 138 431 431 ARG ARG A . n 
A 1 139 GLU 139 432 432 GLU GLU A . n 
A 1 140 VAL 140 433 433 VAL VAL A . n 
A 1 141 GLU 141 434 434 GLU GLU A . n 
A 1 142 ARG 142 435 435 ARG ARG A . n 
A 1 143 PRO 143 436 436 PRO PRO A . n 
A 1 144 LEU 144 437 437 LEU LEU A . n 
A 1 145 SER 145 438 438 SER SER A . n 
A 1 146 ALA 146 439 439 ALA ALA A . n 
A 1 147 VAL 147 440 440 VAL VAL A . n 
A 1 148 LEU 148 441 441 LEU LEU A . n 
A 1 149 ALA 149 442 442 ALA ALA A . n 
A 1 150 HIS 150 443 443 HIS HIS A . n 
A 1 151 MET 151 444 444 MET MET A . n 
A 1 152 GLU 152 445 445 GLU GLU A . n 
A 1 153 ALA 153 446 446 ALA ALA A . n 
A 1 154 THR 154 447 447 THR THR A . n 
A 1 155 GLY 155 448 448 GLY GLY A . n 
A 1 156 VAL 156 449 449 VAL VAL A . n 
A 1 157 ARG 157 450 450 ARG ARG A . n 
A 1 158 LEU 158 451 451 LEU LEU A . n 
A 1 159 ASP 159 452 452 ASP ASP A . n 
A 1 160 VAL 160 453 453 VAL VAL A . n 
A 1 161 ALA 161 454 454 ALA ALA A . n 
A 1 162 TYR 162 455 455 TYR TYR A . n 
A 1 163 LEU 163 456 456 LEU LEU A . n 
A 1 164 ARG 164 457 457 ARG ARG A . n 
A 1 165 ALA 165 458 458 ALA ALA A . n 
A 1 166 LEU 166 459 459 LEU LEU A . n 
A 1 167 SER 167 460 460 SER SER A . n 
A 1 168 LEU 168 461 461 LEU LEU A . n 
A 1 169 GLU 169 462 462 GLU GLU A . n 
A 1 170 VAL 170 463 463 VAL VAL A . n 
A 1 171 ALA 171 464 464 ALA ALA A . n 
A 1 172 GLU 172 465 465 GLU GLU A . n 
A 1 173 GLU 173 466 466 GLU GLU A . n 
A 1 174 ILE 174 467 467 ILE ILE A . n 
A 1 175 ALA 175 468 468 ALA ALA A . n 
A 1 176 ARG 176 469 469 ARG ARG A . n 
A 1 177 LEU 177 470 470 LEU LEU A . n 
A 1 178 GLU 178 471 471 GLU GLU A . n 
A 1 179 ALA 179 472 472 ALA ALA A . n 
A 1 180 GLU 180 473 473 GLU GLU A . n 
A 1 181 VAL 181 474 474 VAL VAL A . n 
A 1 182 PHE 182 475 475 PHE PHE A . n 
A 1 183 ARG 183 476 476 ARG ARG A . n 
A 1 184 LEU 184 477 477 LEU LEU A . n 
A 1 185 ALA 185 478 478 ALA ALA A . n 
A 1 186 GLY 186 479 479 GLY GLY A . n 
A 1 187 HIS 187 480 480 HIS HIS A . n 
A 1 188 PRO 188 481 481 PRO PRO A . n 
A 1 189 PHE 189 482 482 PHE PHE A . n 
A 1 190 ASN 190 483 483 ASN ASN A . n 
A 1 191 LEU 191 484 484 LEU LEU A . n 
A 1 192 ASN 192 485 485 ASN ASN A . n 
A 1 193 SER 193 486 486 SER SER A . n 
A 1 194 ARG 194 487 487 ARG ARG A . n 
A 1 195 ASP 195 488 488 ASP ASP A . n 
A 1 196 GLN 196 489 489 GLN GLN A . n 
A 1 197 LEU 197 490 490 LEU LEU A . n 
A 1 198 GLU 198 491 491 GLU GLU A . n 
A 1 199 ARG 199 492 492 ARG ARG A . n 
A 1 200 VAL 200 493 493 VAL VAL A . n 
A 1 201 LEU 201 494 494 LEU LEU A . n 
A 1 202 PHE 202 495 495 PHE PHE A . n 
A 1 203 ASP 203 496 496 ASP ASP A . n 
A 1 204 GLU 204 497 497 GLU GLU A . n 
A 1 205 LEU 205 498 498 LEU LEU A . n 
A 1 206 GLY 206 499 499 GLY GLY A . n 
A 1 207 LEU 207 500 500 LEU LEU A . n 
A 1 208 PRO 208 501 501 PRO PRO A . n 
A 1 209 ALA 209 502 502 ALA ALA A . n 
A 1 210 ILE 210 503 503 ILE ILE A . n 
A 1 211 GLY 211 504 504 GLY GLY A . n 
A 1 212 LYS 212 505 505 LYS LYS A . n 
A 1 213 THR 213 506 506 THR THR A . n 
A 1 214 GLU 214 507 507 GLU GLU A . n 
A 1 215 LYS 215 508 508 LYS LYS A . n 
A 1 216 THR 216 509 509 THR THR A . n 
A 1 217 GLY 217 510 510 GLY GLY A . n 
A 1 218 LYS 218 511 511 LYS LYS A . n 
A 1 219 ARG 219 512 512 ARG ARG A . n 
A 1 220 SER 220 513 513 SER SER A . n 
A 1 221 THR 221 514 514 THR THR A . n 
A 1 222 SER 222 515 515 SER SER A . n 
A 1 223 ALA 223 516 516 ALA ALA A . n 
A 1 224 ALA 224 517 517 ALA ALA A . n 
A 1 225 ALA 225 518 518 ALA ALA A . n 
A 1 226 LEU 226 519 519 LEU LEU A . n 
A 1 227 GLU 227 520 520 GLU GLU A . n 
A 1 228 ALA 228 521 521 ALA ALA A . n 
A 1 229 LEU 229 522 522 LEU LEU A . n 
A 1 230 ARG 230 523 523 ARG ARG A . n 
A 1 231 GLU 231 524 524 GLU GLU A . n 
A 1 232 ALA 232 525 525 ALA ALA A . n 
A 1 233 HIS 233 526 526 HIS HIS A . n 
A 1 234 PRO 234 527 527 PRO PRO A . n 
A 1 235 ILE 235 528 528 ILE ILE A . n 
A 1 236 VAL 236 529 529 VAL VAL A . n 
A 1 237 GLU 237 530 530 GLU GLU A . n 
A 1 238 LYS 238 531 531 LYS LYS A . n 
A 1 239 ILE 239 532 532 ILE ILE A . n 
A 1 240 LEU 240 533 533 LEU LEU A . n 
A 1 241 GLN 241 534 534 GLN GLN A . n 
A 1 242 TYR 242 535 535 TYR TYR A . n 
A 1 243 ARG 243 536 536 ARG ARG A . n 
A 1 244 GLU 244 537 537 GLU GLU A . n 
A 1 245 LEU 245 538 538 LEU LEU A . n 
A 1 246 THR 246 539 539 THR THR A . n 
A 1 247 LYS 247 540 540 LYS LYS A . n 
A 1 248 LEU 248 541 541 LEU LEU A . n 
A 1 249 LYS 249 542 542 LYS LYS A . n 
A 1 250 SER 250 543 543 SER SER A . n 
A 1 251 THR 251 544 544 THR THR A . n 
A 1 252 TYR 252 545 545 TYR TYR A . n 
A 1 253 ILE 253 546 546 ILE ILE A . n 
A 1 254 ASP 254 547 547 ASP ASP A . n 
A 1 255 PRO 255 548 548 PRO PRO A . n 
A 1 256 LEU 256 549 549 LEU LEU A . n 
A 1 257 PRO 257 550 550 PRO PRO A . n 
A 1 258 ASP 258 551 551 ASP ASP A . n 
A 1 259 LEU 259 552 552 LEU LEU A . n 
A 1 260 ILE 260 553 553 ILE ILE A . n 
A 1 261 HIS 261 554 554 HIS HIS A . n 
A 1 262 PRO 262 555 555 PRO PRO A . n 
A 1 263 ARG 263 556 556 ARG ARG A . n 
A 1 264 THR 264 557 557 THR THR A . n 
A 1 265 GLY 265 558 558 GLY GLY A . n 
A 1 266 ARG 266 559 559 ARG ARG A . n 
A 1 267 LEU 267 560 560 LEU LEU A . n 
A 1 268 HIS 268 561 561 HIS HIS A . n 
A 1 269 THR 269 562 562 THR THR A . n 
A 1 270 ARG 270 563 563 ARG ARG A . n 
A 1 271 PHE 271 564 564 PHE PHE A . n 
A 1 272 ASN 272 565 565 ASN ASN A . n 
A 1 273 GLN 273 566 566 GLN GLN A . n 
A 1 274 THR 274 567 567 THR THR A . n 
A 1 275 ALA 275 568 568 ALA ALA A . n 
A 1 276 THR 276 569 569 THR THR A . n 
A 1 277 ALA 277 570 570 ALA ALA A . n 
A 1 278 THR 278 571 571 THR THR A . n 
A 1 279 GLY 279 572 572 GLY GLY A . n 
A 1 280 ARG 280 573 573 ARG ARG A . n 
A 1 281 LEU 281 574 574 LEU LEU A . n 
A 1 282 SER 282 575 575 SER SER A . n 
A 1 283 SER 283 576 576 SER SER A . n 
A 1 284 SER 284 577 577 SER SER A . n 
A 1 285 ASP 285 578 578 ASP ASP A . n 
A 1 286 PRO 286 579 579 PRO PRO A . n 
A 1 287 ASN 287 580 580 ASN ASN A . n 
A 1 288 LEU 288 581 581 LEU LEU A . n 
A 1 289 GLN 289 582 582 GLN GLN A . n 
A 1 290 SER 290 583 583 SER SER A . n 
A 1 291 ILE 291 584 584 ILE ILE A . n 
A 1 292 PRO 292 585 585 PRO PRO A . n 
A 1 293 VAL 293 586 586 VAL VAL A . n 
A 1 294 ARG 294 587 587 ARG ARG A . n 
A 1 295 THR 295 588 588 THR THR A . n 
A 1 296 PRO 296 589 589 PRO PRO A . n 
A 1 297 LEU 297 590 590 LEU LEU A . n 
A 1 298 GLY 298 591 591 GLY GLY A . n 
A 1 299 GLN 299 592 592 GLN GLN A . n 
A 1 300 ARG 300 593 593 ARG ARG A . n 
A 1 301 ILE 301 594 594 ILE ILE A . n 
A 1 302 ARG 302 595 595 ARG ARG A . n 
A 1 303 ARG 303 596 596 ARG ARG A . n 
A 1 304 ALA 304 597 597 ALA ALA A . n 
A 1 305 PHE 305 598 598 PHE PHE A . n 
A 1 306 ILE 306 599 599 ILE ILE A . n 
A 1 307 ALA 307 600 600 ALA ALA A . n 
A 1 308 GLU 308 601 601 GLU GLU A . n 
A 1 309 GLU 309 602 602 GLU GLU A . n 
A 1 310 GLY 310 603 603 GLY GLY A . n 
A 1 311 TRP 311 604 604 TRP TRP A . n 
A 1 312 LEU 312 605 605 LEU LEU A . n 
A 1 313 LEU 313 606 606 LEU LEU A . n 
A 1 314 VAL 314 607 607 VAL VAL A . n 
A 1 315 ALA 315 608 608 ALA ALA A . n 
A 1 316 LEU 316 609 609 LEU LEU A . n 
A 1 317 ASP 317 610 610 ASP ASP A . n 
A 1 318 TYR 318 611 611 TYR TYR A . n 
A 1 319 SER 319 612 612 SER SER A . n 
A 1 320 GLN 320 613 613 GLN GLN A . n 
A 1 321 GLU 321 614 614 GLU GLU A . n 
A 1 322 GLY 322 615 615 GLY GLY A . n 
A 1 323 LEU 323 616 616 LEU LEU A . n 
A 1 324 ARG 324 617 617 ARG ARG A . n 
A 1 325 VAL 325 618 618 VAL VAL A . n 
A 1 326 LEU 326 619 619 LEU LEU A . n 
A 1 327 ALA 327 620 620 ALA ALA A . n 
A 1 328 HIS 328 621 621 HIS HIS A . n 
A 1 329 LEU 329 622 622 LEU LEU A . n 
A 1 330 SER 330 623 623 SER SER A . n 
A 1 331 GLY 331 624 624 GLY GLY A . n 
A 1 332 ASP 332 625 625 ASP ASP A . n 
A 1 333 GLU 333 626 626 GLU GLU A . n 
A 1 334 ASN 334 627 627 ASN ASN A . n 
A 1 335 LEU 335 628 628 LEU LEU A . n 
A 1 336 ILE 336 629 629 ILE ILE A . n 
A 1 337 ARG 337 630 630 ARG ARG A . n 
A 1 338 VAL 338 631 631 VAL VAL A . n 
A 1 339 PHE 339 632 632 PHE PHE A . n 
A 1 340 GLN 340 633 633 GLN GLN A . n 
A 1 341 GLU 341 634 634 GLU GLU A . n 
A 1 342 GLY 342 635 635 GLY GLY A . n 
A 1 343 ARG 343 636 636 ARG ARG A . n 
A 1 344 ASP 344 637 637 ASP ASP A . n 
A 1 345 ILE 345 638 638 ILE ILE A . n 
A 1 346 HIS 346 639 639 HIS HIS A . n 
A 1 347 THR 347 640 640 THR THR A . n 
A 1 348 GLU 348 641 641 GLU GLU A . n 
A 1 349 THR 349 642 642 THR THR A . n 
A 1 350 ALA 350 643 643 ALA ALA A . n 
A 1 351 SER 351 644 644 SER SER A . n 
A 1 352 TRP 352 645 645 TRP TRP A . n 
A 1 353 MET 353 646 646 MET MET A . n 
A 1 354 PHE 354 647 647 PHE PHE A . n 
A 1 355 GLY 355 648 648 GLY GLY A . n 
A 1 356 VAL 356 649 649 VAL VAL A . n 
A 1 357 PRO 357 650 650 PRO PRO A . n 
A 1 358 ARG 358 651 651 ARG ARG A . n 
A 1 359 GLU 359 652 652 GLU GLU A . n 
A 1 360 ALA 360 653 653 ALA ALA A . n 
A 1 361 VAL 361 654 654 VAL VAL A . n 
A 1 362 ASN 362 655 655 ASN ASN A . n 
A 1 363 PRO 363 656 656 PRO PRO A . n 
A 1 364 LEU 364 657 657 LEU LEU A . n 
A 1 365 MET 365 658 658 MET MET A . n 
A 1 366 ARG 366 659 659 ARG ARG A . n 
A 1 367 ARG 367 660 660 ARG ARG A . n 
A 1 368 ALA 368 661 661 ALA ALA A . n 
A 1 369 ALA 369 662 662 ALA ALA A . n 
A 1 370 LYS 370 663 663 LYS LYS A . n 
A 1 371 THR 371 664 664 THR THR A . n 
A 1 372 ILE 372 665 665 ILE ILE A . n 
A 1 373 ASN 373 666 666 ASN ASN A . n 
A 1 374 PHE 374 667 667 PHE PHE A . n 
A 1 375 GLY 375 668 668 GLY GLY A . n 
A 1 376 VAL 376 669 669 VAL VAL A . n 
A 1 377 LEU 377 670 670 LEU LEU A . n 
A 1 378 TYR 378 671 671 TYR TYR A . n 
A 1 379 GLY 379 672 672 GLY GLY A . n 
A 1 380 MET 380 673 673 MET MET A . n 
A 1 381 SER 381 674 674 SER SER A . n 
A 1 382 ALA 382 675 675 ALA ALA A . n 
A 1 383 HIS 383 676 676 HIS HIS A . n 
A 1 384 ARG 384 677 677 ARG ARG A . n 
A 1 385 LEU 385 678 678 LEU LEU A . n 
A 1 386 SER 386 679 679 SER SER A . n 
A 1 387 GLN 387 680 680 GLN GLN A . n 
A 1 388 LYS 388 681 681 LYS LYS A . n 
A 1 389 LEU 389 682 682 LEU LEU A . n 
A 1 390 ALA 390 683 683 ALA ALA A . n 
A 1 391 ILE 391 684 684 ILE ILE A . n 
A 1 392 PRO 392 685 685 PRO PRO A . n 
A 1 393 TYR 393 686 686 TYR TYR A . n 
A 1 394 GLU 394 687 687 GLU GLU A . n 
A 1 395 GLU 395 688 688 GLU GLU A . n 
A 1 396 ALA 396 689 689 ALA ALA A . n 
A 1 397 GLN 397 690 690 GLN GLN A . n 
A 1 398 ALA 398 691 691 ALA ALA A . n 
A 1 399 PHE 399 692 692 PHE PHE A . n 
A 1 400 ILE 400 693 693 ILE ILE A . n 
A 1 401 GLU 401 694 694 GLU GLU A . n 
A 1 402 ARG 402 695 695 ARG ARG A . n 
A 1 403 TYR 403 696 696 TYR TYR A . n 
A 1 404 PHE 404 697 697 PHE PHE A . n 
A 1 405 GLN 405 698 698 GLN GLN A . n 
A 1 406 SER 406 699 699 SER SER A . n 
A 1 407 PHE 407 700 700 PHE PHE A . n 
A 1 408 PRO 408 701 701 PRO PRO A . n 
A 1 409 LYS 409 702 702 LYS LYS A . n 
A 1 410 VAL 410 703 703 VAL VAL A . n 
A 1 411 ARG 411 704 704 ARG ARG A . n 
A 1 412 ALA 412 705 705 ALA ALA A . n 
A 1 413 TRP 413 706 706 TRP TRP A . n 
A 1 414 ILE 414 707 707 ILE ILE A . n 
A 1 415 GLU 415 708 708 GLU GLU A . n 
A 1 416 LYS 416 709 709 LYS LYS A . n 
A 1 417 THR 417 710 710 THR THR A . n 
A 1 418 LEU 418 711 711 LEU LEU A . n 
A 1 419 GLU 419 712 712 GLU GLU A . n 
A 1 420 GLU 420 713 713 GLU GLU A . n 
A 1 421 GLY 421 714 714 GLY GLY A . n 
A 1 422 ARG 422 715 715 ARG ARG A . n 
A 1 423 ARG 423 716 716 ARG ARG A . n 
A 1 424 ARG 424 717 717 ARG ARG A . n 
A 1 425 GLY 425 718 718 GLY GLY A . n 
A 1 426 TYR 426 719 719 TYR TYR A . n 
A 1 427 VAL 427 720 720 VAL VAL A . n 
A 1 428 GLU 428 721 721 GLU GLU A . n 
A 1 429 THR 429 722 722 THR THR A . n 
A 1 430 LEU 430 723 723 LEU LEU A . n 
A 1 431 PHE 431 724 724 PHE PHE A . n 
A 1 432 GLY 432 725 725 GLY GLY A . n 
A 1 433 ARG 433 726 726 ARG ARG A . n 
A 1 434 ARG 434 727 727 ARG ARG A . n 
A 1 435 ARG 435 728 728 ARG ARG A . n 
A 1 436 TYR 436 729 729 TYR TYR A . n 
A 1 437 VAL 437 730 730 VAL VAL A . n 
A 1 438 PRO 438 731 731 PRO PRO A . n 
A 1 439 ASP 439 732 732 ASP ASP A . n 
A 1 440 LEU 440 733 733 LEU LEU A . n 
A 1 441 GLU 441 734 734 GLU GLU A . n 
A 1 442 ALA 442 735 735 ALA ALA A . n 
A 1 443 ARG 443 736 736 ARG ARG A . n 
A 1 444 VAL 444 737 737 VAL VAL A . n 
A 1 445 LYS 445 738 738 LYS LYS A . n 
A 1 446 SER 446 739 739 SER SER A . n 
A 1 447 VAL 447 740 740 VAL VAL A . n 
A 1 448 ARG 448 741 741 ARG ARG A . n 
A 1 449 GLN 449 742 742 GLN GLN A . n 
A 1 450 ALA 450 743 743 ALA ALA A . n 
A 1 451 ALA 451 744 744 ALA ALA A . n 
A 1 452 GLU 452 745 745 GLU GLU A . n 
A 1 453 ARG 453 746 746 ARG ARG A . n 
A 1 454 ARG 454 747 747 ARG ARG A . n 
A 1 455 ALA 455 748 748 ALA ALA A . n 
A 1 456 PHE 456 749 749 PHE PHE A . n 
A 1 457 ASN 457 750 750 ASN ASN A . n 
A 1 458 MET 458 751 751 MET MET A . n 
A 1 459 PRO 459 752 752 PRO PRO A . n 
A 1 460 VAL 460 753 753 VAL VAL A . n 
A 1 461 GLN 461 754 754 GLN GLN A . n 
A 1 462 GLY 462 755 755 GLY GLY A . n 
A 1 463 THR 463 756 756 THR THR A . n 
A 1 464 ALA 464 757 757 ALA ALA A . n 
A 1 465 ALA 465 758 758 ALA ALA A . n 
A 1 466 ASP 466 759 759 ASP ASP A . n 
A 1 467 LEU 467 760 760 LEU LEU A . n 
A 1 468 MET 468 761 761 MET MET A . n 
A 1 469 LYS 469 762 762 LYS LYS A . n 
A 1 470 LEU 470 763 763 LEU LEU A . n 
A 1 471 ALA 471 764 764 ALA ALA A . n 
A 1 472 MET 472 765 765 MET MET A . n 
A 1 473 VAL 473 766 766 VAL VAL A . n 
A 1 474 LYS 474 767 767 LYS LYS A . n 
A 1 475 LEU 475 768 768 LEU LEU A . n 
A 1 476 PHE 476 769 769 PHE PHE A . n 
A 1 477 PRO 477 770 770 PRO PRO A . n 
A 1 478 ARG 478 771 771 ARG ARG A . n 
A 1 479 LEU 479 772 772 LEU LEU A . n 
A 1 480 GLU 480 773 773 GLU GLU A . n 
A 1 481 GLU 481 774 774 GLU GLU A . n 
A 1 482 MET 482 775 775 MET MET A . n 
A 1 483 GLY 483 776 776 GLY GLY A . n 
A 1 484 ALA 484 777 777 ALA ALA A . n 
A 1 485 ARG 485 778 778 ARG ARG A . n 
A 1 486 MET 486 779 779 MET MET A . n 
A 1 487 LEU 487 780 780 LEU LEU A . n 
A 1 488 LEU 488 781 781 LEU LEU A . n 
A 1 489 GLN 489 782 782 GLN GLN A . n 
A 1 490 VAL 490 783 783 VAL VAL A . n 
A 1 491 HIS 491 784 784 HIS HIS A . n 
A 1 492 ASP 492 785 785 ASP ASP A . n 
A 1 493 GLU 493 786 786 GLU GLU A . n 
A 1 494 LEU 494 787 787 LEU LEU A . n 
A 1 495 VAL 495 788 788 VAL VAL A . n 
A 1 496 LEU 496 789 789 LEU LEU A . n 
A 1 497 GLU 497 790 790 GLU GLU A . n 
A 1 498 ALA 498 791 791 ALA ALA A . n 
A 1 499 PRO 499 792 792 PRO PRO A . n 
A 1 500 LYS 500 793 793 LYS LYS A . n 
A 1 501 GLU 501 794 794 GLU GLU A . n 
A 1 502 ARG 502 795 795 ARG ARG A . n 
A 1 503 ALA 503 796 796 ALA ALA A . n 
A 1 504 GLU 504 797 797 GLU GLU A . n 
A 1 505 ALA 505 798 798 ALA ALA A . n 
A 1 506 VAL 506 799 799 VAL VAL A . n 
A 1 507 ALA 507 800 800 ALA ALA A . n 
A 1 508 ARG 508 801 801 ARG ARG A . n 
A 1 509 LEU 509 802 802 LEU LEU A . n 
A 1 510 ALA 510 803 803 ALA ALA A . n 
A 1 511 LYS 511 804 804 LYS LYS A . n 
A 1 512 GLU 512 805 805 GLU GLU A . n 
A 1 513 VAL 513 806 806 VAL VAL A . n 
A 1 514 MET 514 807 807 MET MET A . n 
A 1 515 GLU 515 808 808 GLU GLU A . n 
A 1 516 GLY 516 809 809 GLY GLY A . n 
A 1 517 VAL 517 810 810 VAL VAL A . n 
A 1 518 TYR 518 811 811 TYR TYR A . n 
A 1 519 PRO 519 812 812 PRO PRO A . n 
A 1 520 LEU 520 813 813 LEU LEU A . n 
A 1 521 ALA 521 814 814 ALA ALA A . n 
A 1 522 VAL 522 815 815 VAL VAL A . n 
A 1 523 PRO 523 816 816 PRO PRO A . n 
A 1 524 LEU 524 817 817 LEU LEU A . n 
A 1 525 GLU 525 818 818 GLU GLU A . n 
A 1 526 VAL 526 819 819 VAL VAL A . n 
A 1 527 GLU 527 820 820 GLU GLU A . n 
A 1 528 VAL 528 821 821 VAL VAL A . n 
A 1 529 GLY 529 822 822 GLY GLY A . n 
A 1 530 ILE 530 823 823 ILE ILE A . n 
A 1 531 GLY 531 824 824 GLY GLY A . n 
A 1 532 GLU 532 825 825 GLU GLU A . n 
A 1 533 ASP 533 826 826 ASP ASP A . n 
A 1 534 TRP 534 827 827 TRP TRP A . n 
A 1 535 LEU 535 828 828 LEU LEU A . n 
A 1 536 SER 536 829 829 SER SER A . n 
A 1 537 ALA 537 830 830 ALA ALA A . n 
A 1 538 LYS 538 831 831 LYS LYS A . n 
A 1 539 GLU 539 832 832 GLU GLU A . n 
A 1 540 ALA 540 833 833 ALA ALA A . n 
A 1 541 ALA 541 834 834 ALA ALA A . n 
A 1 542 LYS 542 835 835 LYS LYS A . n 
A 1 543 LEU 543 836 836 LEU LEU A . n 
A 1 544 ALA 544 837 837 ALA ALA A . n 
A 1 545 ALA 545 838 838 ALA ALA A . n 
A 1 546 ALA 546 839 839 ALA ALA A . n 
A 1 547 LEU 547 840 840 LEU LEU A . n 
A 1 548 GLU 548 841 841 GLU GLU A . n 
A 1 549 HIS 549 842 ?   ?   ?   A . n 
A 1 550 HIS 550 843 ?   ?   ?   A . n 
A 1 551 HIS 551 844 ?   ?   ?   A . n 
A 1 552 HIS 552 845 ?   ?   ?   A . n 
A 1 553 HIS 553 846 ?   ?   ?   A . n 
A 1 554 HIS 554 847 ?   ?   ?   A . n 
B 2 1   DA  1   202 202 DA  DA  B . n 
B 2 2   DA  2   203 203 DA  DA  B . n 
B 2 3   DA  3   204 204 DA  DA  B . n 
B 2 4   DC  4   205 205 DC  DC  B . n 
B 2 5   DG  5   206 206 DG  DG  B . n 
B 2 6   DG  6   207 207 DG  DG  B . n 
B 2 7   DC  7   208 208 DC  DC  B . n 
B 2 8   DG  8   209 209 DG  DG  B . n 
B 2 9   DC  9   210 210 DC  DC  B . n 
B 2 10  DC  10  211 211 DC  DC  B . n 
B 2 11  DG  11  212 212 DG  DG  B . n 
B 2 12  DT  12  213 213 DT  DT  B . n 
B 2 13  DG  13  214 214 DG  DG  B . n 
B 2 14  DG  14  215 215 DG  DG  B . n 
B 2 15  DT  15  216 216 DT  DT  B . n 
B 2 16  DC  16  217 217 DC  DC  B . n 
B 2 17  OMG 17  218 218 OMG OMG B . n 
C 3 1   DG  1   100 100 DG  DG  C . n 
C 3 2   DA  2   101 101 DA  DA  C . n 
C 3 3   DC  3   102 102 DC  DC  C . n 
C 3 4   DC  4   103 103 DC  DC  C . n 
C 3 5   DA  5   104 104 DA  DA  C . n 
C 3 6   DC  6   105 105 DC  DC  C . n 
C 3 7   DG  7   106 106 DG  DG  C . n 
C 3 8   DG  8   107 107 DG  DG  C . n 
C 3 9   DC  9   108 108 DC  DC  C . n 
C 3 10  DG  10  109 109 DG  DG  C . n 
C 3 11  DC  11  110 110 DC  DC  C . n 
C 3 12  DC  12  111 111 DC  DC  C . n 
C 3 13  OMG 13  112 112 OMG OMG C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        OMG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   OMG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 PO4 1   901  1   PO4 PO4 A . 
E 4 PO4 1   902  2   PO4 PO4 A . 
F 5 SO4 1   903  3   SO4 SO4 A . 
G 5 SO4 1   904  4   SO4 SO4 A . 
H 5 SO4 1   905  5   SO4 SO4 A . 
I 6 PEG 1   906  6   PEG PEG A . 
J 7 HOH 1   1001 181 HOH HOH A . 
J 7 HOH 2   1002 256 HOH HOH A . 
J 7 HOH 3   1003 262 HOH HOH A . 
J 7 HOH 4   1004 271 HOH HOH A . 
J 7 HOH 5   1005 163 HOH HOH A . 
J 7 HOH 6   1006 19  HOH HOH A . 
J 7 HOH 7   1007 123 HOH HOH A . 
J 7 HOH 8   1008 101 HOH HOH A . 
J 7 HOH 9   1009 248 HOH HOH A . 
J 7 HOH 10  1010 167 HOH HOH A . 
J 7 HOH 11  1011 274 HOH HOH A . 
J 7 HOH 12  1012 247 HOH HOH A . 
J 7 HOH 13  1013 76  HOH HOH A . 
J 7 HOH 14  1014 119 HOH HOH A . 
J 7 HOH 15  1015 127 HOH HOH A . 
J 7 HOH 16  1016 86  HOH HOH A . 
J 7 HOH 17  1017 160 HOH HOH A . 
J 7 HOH 18  1018 146 HOH HOH A . 
J 7 HOH 19  1019 135 HOH HOH A . 
J 7 HOH 20  1020 230 HOH HOH A . 
J 7 HOH 21  1021 350 HOH HOH A . 
J 7 HOH 22  1022 90  HOH HOH A . 
J 7 HOH 23  1023 145 HOH HOH A . 
J 7 HOH 24  1024 191 HOH HOH A . 
J 7 HOH 25  1025 122 HOH HOH A . 
J 7 HOH 26  1026 175 HOH HOH A . 
J 7 HOH 27  1027 264 HOH HOH A . 
J 7 HOH 28  1028 305 HOH HOH A . 
J 7 HOH 29  1029 131 HOH HOH A . 
J 7 HOH 30  1030 14  HOH HOH A . 
J 7 HOH 31  1031 330 HOH HOH A . 
J 7 HOH 32  1032 190 HOH HOH A . 
J 7 HOH 33  1033 252 HOH HOH A . 
J 7 HOH 34  1034 324 HOH HOH A . 
J 7 HOH 35  1035 112 HOH HOH A . 
J 7 HOH 36  1036 344 HOH HOH A . 
J 7 HOH 37  1037 95  HOH HOH A . 
J 7 HOH 38  1038 205 HOH HOH A . 
J 7 HOH 39  1039 82  HOH HOH A . 
J 7 HOH 40  1040 232 HOH HOH A . 
J 7 HOH 41  1041 83  HOH HOH A . 
J 7 HOH 42  1042 148 HOH HOH A . 
J 7 HOH 43  1043 194 HOH HOH A . 
J 7 HOH 44  1044 93  HOH HOH A . 
J 7 HOH 45  1045 273 HOH HOH A . 
J 7 HOH 46  1046 25  HOH HOH A . 
J 7 HOH 47  1047 91  HOH HOH A . 
J 7 HOH 48  1048 106 HOH HOH A . 
J 7 HOH 49  1049 251 HOH HOH A . 
J 7 HOH 50  1050 140 HOH HOH A . 
J 7 HOH 51  1051 311 HOH HOH A . 
J 7 HOH 52  1052 295 HOH HOH A . 
J 7 HOH 53  1053 27  HOH HOH A . 
J 7 HOH 54  1054 320 HOH HOH A . 
J 7 HOH 55  1055 110 HOH HOH A . 
J 7 HOH 56  1056 222 HOH HOH A . 
J 7 HOH 57  1057 174 HOH HOH A . 
J 7 HOH 58  1058 212 HOH HOH A . 
J 7 HOH 59  1059 255 HOH HOH A . 
J 7 HOH 60  1060 88  HOH HOH A . 
J 7 HOH 61  1061 68  HOH HOH A . 
J 7 HOH 62  1062 33  HOH HOH A . 
J 7 HOH 63  1063 107 HOH HOH A . 
J 7 HOH 64  1064 104 HOH HOH A . 
J 7 HOH 65  1065 325 HOH HOH A . 
J 7 HOH 66  1066 192 HOH HOH A . 
J 7 HOH 67  1067 347 HOH HOH A . 
J 7 HOH 68  1068 97  HOH HOH A . 
J 7 HOH 69  1069 263 HOH HOH A . 
J 7 HOH 70  1070 313 HOH HOH A . 
J 7 HOH 71  1071 238 HOH HOH A . 
J 7 HOH 72  1072 239 HOH HOH A . 
J 7 HOH 73  1073 225 HOH HOH A . 
J 7 HOH 74  1074 54  HOH HOH A . 
J 7 HOH 75  1075 217 HOH HOH A . 
J 7 HOH 76  1076 118 HOH HOH A . 
J 7 HOH 77  1077 53  HOH HOH A . 
J 7 HOH 78  1078 316 HOH HOH A . 
J 7 HOH 79  1079 80  HOH HOH A . 
J 7 HOH 80  1080 117 HOH HOH A . 
J 7 HOH 81  1081 3   HOH HOH A . 
J 7 HOH 82  1082 312 HOH HOH A . 
J 7 HOH 83  1083 196 HOH HOH A . 
J 7 HOH 84  1084 152 HOH HOH A . 
J 7 HOH 85  1085 71  HOH HOH A . 
J 7 HOH 86  1086 89  HOH HOH A . 
J 7 HOH 87  1087 55  HOH HOH A . 
J 7 HOH 88  1088 223 HOH HOH A . 
J 7 HOH 89  1089 246 HOH HOH A . 
J 7 HOH 90  1090 233 HOH HOH A . 
J 7 HOH 91  1091 10  HOH HOH A . 
J 7 HOH 92  1092 268 HOH HOH A . 
J 7 HOH 93  1093 36  HOH HOH A . 
J 7 HOH 94  1094 142 HOH HOH A . 
J 7 HOH 95  1095 52  HOH HOH A . 
J 7 HOH 96  1096 173 HOH HOH A . 
J 7 HOH 97  1097 234 HOH HOH A . 
J 7 HOH 98  1098 141 HOH HOH A . 
J 7 HOH 99  1099 102 HOH HOH A . 
J 7 HOH 100 1100 300 HOH HOH A . 
J 7 HOH 101 1101 1   HOH HOH A . 
J 7 HOH 102 1102 243 HOH HOH A . 
J 7 HOH 103 1103 291 HOH HOH A . 
J 7 HOH 104 1104 136 HOH HOH A . 
J 7 HOH 105 1105 333 HOH HOH A . 
J 7 HOH 106 1106 161 HOH HOH A . 
J 7 HOH 107 1107 236 HOH HOH A . 
J 7 HOH 108 1108 7   HOH HOH A . 
J 7 HOH 109 1109 38  HOH HOH A . 
J 7 HOH 110 1110 61  HOH HOH A . 
J 7 HOH 111 1111 144 HOH HOH A . 
J 7 HOH 112 1112 58  HOH HOH A . 
J 7 HOH 113 1113 306 HOH HOH A . 
J 7 HOH 114 1114 203 HOH HOH A . 
J 7 HOH 115 1115 301 HOH HOH A . 
J 7 HOH 116 1116 224 HOH HOH A . 
J 7 HOH 117 1117 231 HOH HOH A . 
J 7 HOH 118 1118 170 HOH HOH A . 
J 7 HOH 119 1119 43  HOH HOH A . 
J 7 HOH 120 1120 269 HOH HOH A . 
J 7 HOH 121 1121 303 HOH HOH A . 
J 7 HOH 122 1122 108 HOH HOH A . 
J 7 HOH 123 1123 290 HOH HOH A . 
J 7 HOH 124 1124 293 HOH HOH A . 
J 7 HOH 125 1125 69  HOH HOH A . 
J 7 HOH 126 1126 221 HOH HOH A . 
J 7 HOH 127 1127 73  HOH HOH A . 
J 7 HOH 128 1128 179 HOH HOH A . 
J 7 HOH 129 1129 41  HOH HOH A . 
J 7 HOH 130 1130 319 HOH HOH A . 
J 7 HOH 131 1131 99  HOH HOH A . 
J 7 HOH 132 1132 261 HOH HOH A . 
J 7 HOH 133 1133 30  HOH HOH A . 
J 7 HOH 134 1134 44  HOH HOH A . 
J 7 HOH 135 1135 78  HOH HOH A . 
J 7 HOH 136 1136 63  HOH HOH A . 
J 7 HOH 137 1137 16  HOH HOH A . 
J 7 HOH 138 1138 182 HOH HOH A . 
J 7 HOH 139 1139 26  HOH HOH A . 
J 7 HOH 140 1140 349 HOH HOH A . 
J 7 HOH 141 1141 302 HOH HOH A . 
J 7 HOH 142 1142 138 HOH HOH A . 
J 7 HOH 143 1143 315 HOH HOH A . 
J 7 HOH 144 1144 229 HOH HOH A . 
J 7 HOH 145 1145 17  HOH HOH A . 
J 7 HOH 146 1146 228 HOH HOH A . 
J 7 HOH 147 1147 121 HOH HOH A . 
J 7 HOH 148 1148 56  HOH HOH A . 
J 7 HOH 149 1149 100 HOH HOH A . 
J 7 HOH 150 1150 40  HOH HOH A . 
J 7 HOH 151 1151 279 HOH HOH A . 
J 7 HOH 152 1152 162 HOH HOH A . 
J 7 HOH 153 1153 211 HOH HOH A . 
J 7 HOH 154 1154 322 HOH HOH A . 
J 7 HOH 155 1155 75  HOH HOH A . 
J 7 HOH 156 1156 31  HOH HOH A . 
J 7 HOH 157 1157 250 HOH HOH A . 
J 7 HOH 158 1158 79  HOH HOH A . 
J 7 HOH 159 1159 337 HOH HOH A . 
J 7 HOH 160 1160 154 HOH HOH A . 
J 7 HOH 161 1161 164 HOH HOH A . 
J 7 HOH 162 1162 275 HOH HOH A . 
J 7 HOH 163 1163 277 HOH HOH A . 
J 7 HOH 164 1164 29  HOH HOH A . 
J 7 HOH 165 1165 185 HOH HOH A . 
J 7 HOH 166 1166 326 HOH HOH A . 
J 7 HOH 167 1167 39  HOH HOH A . 
J 7 HOH 168 1168 213 HOH HOH A . 
J 7 HOH 169 1169 120 HOH HOH A . 
J 7 HOH 170 1170 171 HOH HOH A . 
J 7 HOH 171 1171 60  HOH HOH A . 
J 7 HOH 172 1172 4   HOH HOH A . 
J 7 HOH 173 1173 13  HOH HOH A . 
J 7 HOH 174 1174 130 HOH HOH A . 
J 7 HOH 175 1175 307 HOH HOH A . 
J 7 HOH 176 1176 227 HOH HOH A . 
J 7 HOH 177 1177 327 HOH HOH A . 
J 7 HOH 178 1178 15  HOH HOH A . 
J 7 HOH 179 1179 81  HOH HOH A . 
J 7 HOH 180 1180 72  HOH HOH A . 
J 7 HOH 181 1181 64  HOH HOH A . 
J 7 HOH 182 1182 35  HOH HOH A . 
J 7 HOH 183 1183 57  HOH HOH A . 
J 7 HOH 184 1184 18  HOH HOH A . 
J 7 HOH 185 1185 296 HOH HOH A . 
J 7 HOH 186 1186 66  HOH HOH A . 
J 7 HOH 187 1187 115 HOH HOH A . 
J 7 HOH 188 1188 318 HOH HOH A . 
J 7 HOH 189 1189 128 HOH HOH A . 
J 7 HOH 190 1190 87  HOH HOH A . 
J 7 HOH 191 1191 46  HOH HOH A . 
J 7 HOH 192 1192 289 HOH HOH A . 
J 7 HOH 193 1193 298 HOH HOH A . 
J 7 HOH 194 1194 92  HOH HOH A . 
J 7 HOH 195 1195 6   HOH HOH A . 
J 7 HOH 196 1196 321 HOH HOH A . 
J 7 HOH 197 1197 288 HOH HOH A . 
J 7 HOH 198 1198 276 HOH HOH A . 
J 7 HOH 199 1199 32  HOH HOH A . 
J 7 HOH 200 1200 281 HOH HOH A . 
J 7 HOH 201 1201 189 HOH HOH A . 
J 7 HOH 202 1202 201 HOH HOH A . 
J 7 HOH 203 1203 172 HOH HOH A . 
J 7 HOH 204 1204 218 HOH HOH A . 
J 7 HOH 205 1205 98  HOH HOH A . 
J 7 HOH 206 1206 323 HOH HOH A . 
J 7 HOH 207 1207 8   HOH HOH A . 
J 7 HOH 208 1208 199 HOH HOH A . 
J 7 HOH 209 1209 308 HOH HOH A . 
J 7 HOH 210 1210 216 HOH HOH A . 
J 7 HOH 211 1211 188 HOH HOH A . 
J 7 HOH 212 1212 47  HOH HOH A . 
J 7 HOH 213 1213 48  HOH HOH A . 
J 7 HOH 214 1214 317 HOH HOH A . 
J 7 HOH 215 1215 351 HOH HOH A . 
J 7 HOH 216 1216 245 HOH HOH A . 
J 7 HOH 217 1217 9   HOH HOH A . 
J 7 HOH 218 1218 5   HOH HOH A . 
J 7 HOH 219 1219 105 HOH HOH A . 
J 7 HOH 220 1220 304 HOH HOH A . 
J 7 HOH 221 1221 186 HOH HOH A . 
J 7 HOH 222 1222 297 HOH HOH A . 
J 7 HOH 223 1223 287 HOH HOH A . 
J 7 HOH 224 1224 346 HOH HOH A . 
J 7 HOH 225 1225 37  HOH HOH A . 
J 7 HOH 226 1226 96  HOH HOH A . 
J 7 HOH 227 1227 42  HOH HOH A . 
J 7 HOH 228 1228 143 HOH HOH A . 
J 7 HOH 229 1229 343 HOH HOH A . 
J 7 HOH 230 1230 51  HOH HOH A . 
J 7 HOH 231 1231 286 HOH HOH A . 
J 7 HOH 232 1232 77  HOH HOH A . 
J 7 HOH 233 1233 309 HOH HOH A . 
J 7 HOH 234 1234 348 HOH HOH A . 
J 7 HOH 235 1235 328 HOH HOH A . 
J 7 HOH 236 1236 116 HOH HOH A . 
J 7 HOH 237 1237 139 HOH HOH A . 
J 7 HOH 238 1238 266 HOH HOH A . 
J 7 HOH 239 1239 294 HOH HOH A . 
J 7 HOH 240 1240 111 HOH HOH A . 
J 7 HOH 241 1241 197 HOH HOH A . 
J 7 HOH 242 1242 285 HOH HOH A . 
J 7 HOH 243 1243 114 HOH HOH A . 
J 7 HOH 244 1244 67  HOH HOH A . 
J 7 HOH 245 1245 208 HOH HOH A . 
J 7 HOH 246 1246 340 HOH HOH A . 
J 7 HOH 247 1247 341 HOH HOH A . 
J 7 HOH 248 1248 310 HOH HOH A . 
J 7 HOH 249 1249 359 HOH HOH A . 
J 7 HOH 250 1250 358 HOH HOH A . 
J 7 HOH 251 1251 283 HOH HOH A . 
J 7 HOH 252 1252 165 HOH HOH A . 
J 7 HOH 253 1253 209 HOH HOH A . 
J 7 HOH 254 1254 177 HOH HOH A . 
J 7 HOH 255 1255 284 HOH HOH A . 
J 7 HOH 256 1256 331 HOH HOH A . 
J 7 HOH 257 1257 166 HOH HOH A . 
J 7 HOH 258 1258 355 HOH HOH A . 
J 7 HOH 259 1259 356 HOH HOH A . 
J 7 HOH 260 1260 357 HOH HOH A . 
J 7 HOH 261 1261 129 HOH HOH A . 
J 7 HOH 262 1262 354 HOH HOH A . 
J 7 HOH 263 1263 156 HOH HOH A . 
J 7 HOH 264 1264 169 HOH HOH A . 
J 7 HOH 265 1265 334 HOH HOH A . 
J 7 HOH 266 1266 280 HOH HOH A . 
J 7 HOH 267 1267 339 HOH HOH A . 
J 7 HOH 268 1268 332 HOH HOH A . 
J 7 HOH 269 1269 329 HOH HOH A . 
J 7 HOH 270 1270 338 HOH HOH A . 
J 7 HOH 271 1271 345 HOH HOH A . 
J 7 HOH 272 1272 336 HOH HOH A . 
K 7 HOH 1   301  267 HOH HOH B . 
K 7 HOH 2   302  235 HOH HOH B . 
K 7 HOH 3   303  62  HOH HOH B . 
K 7 HOH 4   304  202 HOH HOH B . 
K 7 HOH 5   305  183 HOH HOH B . 
K 7 HOH 6   306  23  HOH HOH B . 
K 7 HOH 7   307  45  HOH HOH B . 
K 7 HOH 8   308  133 HOH HOH B . 
K 7 HOH 9   309  149 HOH HOH B . 
K 7 HOH 10  310  84  HOH HOH B . 
K 7 HOH 11  311  253 HOH HOH B . 
K 7 HOH 12  312  147 HOH HOH B . 
K 7 HOH 13  313  49  HOH HOH B . 
K 7 HOH 14  314  178 HOH HOH B . 
K 7 HOH 15  315  314 HOH HOH B . 
K 7 HOH 16  316  70  HOH HOH B . 
K 7 HOH 17  317  265 HOH HOH B . 
K 7 HOH 18  318  2   HOH HOH B . 
K 7 HOH 19  319  249 HOH HOH B . 
K 7 HOH 20  320  193 HOH HOH B . 
K 7 HOH 21  321  259 HOH HOH B . 
K 7 HOH 22  322  125 HOH HOH B . 
K 7 HOH 23  323  22  HOH HOH B . 
K 7 HOH 24  324  220 HOH HOH B . 
K 7 HOH 25  325  150 HOH HOH B . 
K 7 HOH 26  326  353 HOH HOH B . 
K 7 HOH 27  327  132 HOH HOH B . 
K 7 HOH 28  328  34  HOH HOH B . 
K 7 HOH 29  329  272 HOH HOH B . 
K 7 HOH 30  330  28  HOH HOH B . 
K 7 HOH 31  331  240 HOH HOH B . 
K 7 HOH 32  332  242 HOH HOH B . 
K 7 HOH 33  333  65  HOH HOH B . 
K 7 HOH 34  334  153 HOH HOH B . 
K 7 HOH 35  335  59  HOH HOH B . 
K 7 HOH 36  336  352 HOH HOH B . 
K 7 HOH 37  337  94  HOH HOH B . 
K 7 HOH 38  338  257 HOH HOH B . 
K 7 HOH 39  339  210 HOH HOH B . 
K 7 HOH 40  340  335 HOH HOH B . 
K 7 HOH 41  341  204 HOH HOH B . 
K 7 HOH 42  342  176 HOH HOH B . 
L 7 HOH 1   201  260 HOH HOH C . 
L 7 HOH 2   202  270 HOH HOH C . 
L 7 HOH 3   203  226 HOH HOH C . 
L 7 HOH 4   204  50  HOH HOH C . 
L 7 HOH 5   205  278 HOH HOH C . 
L 7 HOH 6   206  113 HOH HOH C . 
L 7 HOH 7   207  11  HOH HOH C . 
L 7 HOH 8   208  195 HOH HOH C . 
L 7 HOH 9   209  180 HOH HOH C . 
L 7 HOH 10  210  20  HOH HOH C . 
L 7 HOH 11  211  24  HOH HOH C . 
L 7 HOH 12  212  168 HOH HOH C . 
L 7 HOH 13  213  159 HOH HOH C . 
L 7 HOH 14  214  103 HOH HOH C . 
L 7 HOH 15  215  155 HOH HOH C . 
L 7 HOH 16  216  124 HOH HOH C . 
L 7 HOH 17  217  237 HOH HOH C . 
L 7 HOH 18  218  21  HOH HOH C . 
L 7 HOH 19  219  207 HOH HOH C . 
L 7 HOH 20  220  137 HOH HOH C . 
L 7 HOH 21  221  244 HOH HOH C . 
L 7 HOH 22  222  126 HOH HOH C . 
L 7 HOH 23  223  254 HOH HOH C . 
L 7 HOH 24  224  187 HOH HOH C . 
L 7 HOH 25  225  12  HOH HOH C . 
L 7 HOH 26  226  158 HOH HOH C . 
L 7 HOH 27  227  215 HOH HOH C . 
L 7 HOH 28  228  157 HOH HOH C . 
L 7 HOH 29  229  134 HOH HOH C . 
L 7 HOH 30  230  206 HOH HOH C . 
L 7 HOH 31  231  241 HOH HOH C . 
L 7 HOH 32  232  342 HOH HOH C . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A GLU 524 ? CG  ? A GLU 231 CG  
2 1 Y 1 A GLU 524 ? CD  ? A GLU 231 CD  
3 1 Y 1 A GLU 524 ? OE1 ? A GLU 231 OE1 
4 1 Y 1 A GLU 524 ? OE2 ? A GLU 231 OE2 
5 1 Y 1 A GLU 687 ? CG  ? A GLU 394 CG  
6 1 Y 1 A GLU 687 ? CD  ? A GLU 394 CD  
7 1 Y 1 A GLU 687 ? OE1 ? A GLU 394 OE1 
8 1 Y 1 A GLU 687 ? OE2 ? A GLU 394 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC    ? ? ? 5.8.0352 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALEPACK ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000  ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   103.51 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8XK7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     61.610 
_cell.length_a_esd                 ? 
_cell.length_b                     65.628 
_cell.length_b_esd                 ? 
_cell.length_c                     107.378 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8XK7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8XK7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.94 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          58.19 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M lithium sulfate monohydrate, 0.1 M HEPES pH 7.5, and 28% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-12-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL18U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL18U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8XK7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     55909 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.290 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.148 
_reflns.pdbx_Rpim_I_all                                0.060 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       343365 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.974 
_reflns.pdbx_CC_star                                   0.993 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.135 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.00 2.03  ? ? ? ? ? ? 2777 ? ? ? ? ? ? ? ? ? ? ? 6.3 0.541 ? ? 0.640 0.255 ? 1  1 0.915 0.978 ? 99.7 ? 0.586 ? ? ? ? ? ? ? ? ? 
2.03 2.07  ? ? ? ? ? ? 2824 ? ? ? ? ? ? ? ? ? ? ? 6.3 0.576 ? ? 0.586 0.233 ? 2  1 0.927 0.981 ? 99.8 ? 0.537 ? ? ? ? ? ? ? ? ? 
2.07 2.11  ? ? ? ? ? ? 2789 ? ? ? ? ? ? ? ? ? ? ? 6.3 0.594 ? ? 0.519 0.206 ? 3  1 0.950 0.987 ? 99.5 ? 0.475 ? ? ? ? ? ? ? ? ? 
2.11 2.15  ? ? ? ? ? ? 2777 ? ? ? ? ? ? ? ? ? ? ? 6.2 0.624 ? ? 0.431 0.172 ? 4  1 0.955 0.988 ? 99.2 ? 0.394 ? ? ? ? ? ? ? ? ? 
2.15 2.20  ? ? ? ? ? ? 2809 ? ? ? ? ? ? ? ? ? ? ? 6.2 0.637 ? ? 0.390 0.156 ? 5  1 0.972 0.993 ? 99.0 ? 0.357 ? ? ? ? ? ? ? ? ? 
2.20 2.25  ? ? ? ? ? ? 2772 ? ? ? ? ? ? ? ? ? ? ? 6.2 0.720 ? ? 0.337 0.135 ? 6  1 0.970 0.992 ? 98.8 ? 0.308 ? ? ? ? ? ? ? ? ? 
2.25 2.31  ? ? ? ? ? ? 2732 ? ? ? ? ? ? ? ? ? ? ? 6.1 0.804 ? ? 0.315 0.127 ? 7  1 0.963 0.990 ? 98.0 ? 0.288 ? ? ? ? ? ? ? ? ? 
2.31 2.37  ? ? ? ? ? ? 2743 ? ? ? ? ? ? ? ? ? ? ? 5.7 0.857 ? ? 0.284 0.119 ? 8  1 0.963 0.990 ? 96.3 ? 0.257 ? ? ? ? ? ? ? ? ? 
2.37 2.44  ? ? ? ? ? ? 2735 ? ? ? ? ? ? ? ? ? ? ? 5.8 0.937 ? ? 0.257 0.106 ? 9  1 0.969 0.992 ? 97.9 ? 0.234 ? ? ? ? ? ? ? ? ? 
2.44 2.52  ? ? ? ? ? ? 2832 ? ? ? ? ? ? ? ? ? ? ? 6.5 1.065 ? ? 0.241 0.095 ? 10 1 0.975 0.994 ? 99.8 ? 0.222 ? ? ? ? ? ? ? ? ? 
2.52 2.61  ? ? ? ? ? ? 2785 ? ? ? ? ? ? ? ? ? ? ? 6.4 1.114 ? ? 0.226 0.089 ? 11 1 0.975 0.994 ? 99.8 ? 0.208 ? ? ? ? ? ? ? ? ? 
2.61 2.71  ? ? ? ? ? ? 2824 ? ? ? ? ? ? ? ? ? ? ? 6.4 1.263 ? ? 0.208 0.082 ? 12 1 0.979 0.995 ? 99.8 ? 0.191 ? ? ? ? ? ? ? ? ? 
2.71 2.84  ? ? ? ? ? ? 2827 ? ? ? ? ? ? ? ? ? ? ? 6.3 1.321 ? ? 0.189 0.075 ? 13 1 0.979 0.995 ? 99.6 ? 0.173 ? ? ? ? ? ? ? ? ? 
2.84 2.99  ? ? ? ? ? ? 2820 ? ? ? ? ? ? ? ? ? ? ? 6.3 1.463 ? ? 0.171 0.069 ? 14 1 0.982 0.995 ? 99.4 ? 0.157 ? ? ? ? ? ? ? ? ? 
2.99 3.17  ? ? ? ? ? ? 2773 ? ? ? ? ? ? ? ? ? ? ? 6.1 1.700 ? ? 0.156 0.063 ? 15 1 0.985 0.996 ? 99.2 ? 0.142 ? ? ? ? ? ? ? ? ? 
3.17 3.42  ? ? ? ? ? ? 2766 ? ? ? ? ? ? ? ? ? ? ? 5.7 2.073 ? ? 0.141 0.059 ? 16 1 0.985 0.996 ? 96.8 ? 0.128 ? ? ? ? ? ? ? ? ? 
3.42 3.76  ? ? ? ? ? ? 2787 ? ? ? ? ? ? ? ? ? ? ? 6.0 2.253 ? ? 0.127 0.052 ? 17 1 0.987 0.997 ? 98.6 ? 0.115 ? ? ? ? ? ? ? ? ? 
3.76 4.31  ? ? ? ? ? ? 2842 ? ? ? ? ? ? ? ? ? ? ? 6.3 2.443 ? ? 0.120 0.048 ? 18 1 0.988 0.997 ? 99.5 ? 0.109 ? ? ? ? ? ? ? ? ? 
4.31 5.43  ? ? ? ? ? ? 2839 ? ? ? ? ? ? ? ? ? ? ? 6.1 2.370 ? ? 0.116 0.047 ? 19 1 0.988 0.997 ? 99.3 ? 0.106 ? ? ? ? ? ? ? ? ? 
5.43 50.00 ? ? ? ? ? ? 2856 ? ? ? ? ? ? ? ? ? ? ? 5.6 2.610 ? ? 0.117 0.049 ? 20 1 0.989 0.997 ? 96.7 ? 0.106 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            1.66 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            -1.33 
_refine.aniso_B[2][2]                            3.74 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -4.27 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.354 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.962 
_refine.correlation_coeff_Fo_to_Fc_free          0.946 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8XK7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             24.41 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     53014 
_refine.ls_number_reflns_R_free                  2832 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.77 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.19347 
_refine.ls_R_factor_R_free                       0.23110 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.19151 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.160 
_refine.pdbx_overall_ESU_R_Free                  0.150 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.568 
_refine.overall_SU_ML                            0.122 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        24.41 
_refine_hist.number_atoms_solvent             346 
_refine_hist.number_atoms_total               5312 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4315 
_refine_hist.pdbx_number_atoms_nucleic_acid   619 
_refine_hist.pdbx_number_atoms_ligand         32 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005  0.012  5146  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  4516  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.363  1.667  7099  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.386  1.548  10502 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 5.837  5.000  549   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 12.959 10.000 55    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.286 10.000 768   ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.081  0.200  784   ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  5531  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1015  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.282  3.695  2193  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.282  3.695  2193  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 3.293  5.533  2743  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 3.294  5.536  2744  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 2.843  4.130  2953  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.842  4.131  2954  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.326  6.076  4357  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.957  46.275 5989  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 5.957  46.280 5990  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.000 
_refine_ls_shell.d_res_low                        2.052 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             224 
_refine_ls_shell.number_reflns_R_work             3894 
_refine_ls_shell.percent_reflns_obs               99.13 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.283 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.308 
# 
_struct.entry_id                     8XK7 
_struct.title                        'binary complex of DNA polymerase SFM4-3 recognizing C2 methyoxy nucleotide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8XK7 
_struct_keywords.text            'DNA polymerase, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 7 ? 
L N N 7 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP DPO1_THEAQ P19821 ? 1 
;LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDP
MLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDV
AYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKIL
QYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQ
IELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFI
ERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLE
EMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
;
294 
2 PDB 8XK7       8XK7   ? 2 ? 1   
3 PDB 8XK7       8XK7   ? 3 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8XK7 A 1 ? 539 ? P19821 294 ? 832 ? 294 832 
2 2 8XK7 B 1 ? 17  ? 8XK7   202 ? 218 ? 202 218 
3 3 8XK7 C 1 ? 13  ? 8XK7   100 ? 112 ? 100 112 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8XK7 MET A 1   ? UNP P19821 LEU 294 conflict         294 1  
1 8XK7 ALA A 225 ? UNP P19821 VAL 518 conflict         518 2  
1 8XK7 SER A 290 ? UNP P19821 ASN 583 conflict         583 3  
1 8XK7 GLU A 321 ? UNP P19821 ILE 614 conflict         614 4  
1 8XK7 GLY A 322 ? UNP P19821 GLU 615 conflict         615 5  
1 8XK7 ASN A 362 ? UNP P19821 ASP 655 conflict         655 6  
1 8XK7 LYS A 388 ? UNP P19821 GLU 681 conflict         681 7  
1 8XK7 GLN A 449 ? UNP P19821 GLU 742 conflict         742 8  
1 8XK7 ARG A 454 ? UNP P19821 MET 747 conflict         747 9  
1 8XK7 ALA A 540 ? UNP P19821 ?   ?   'expression tag' 833 10 
1 8XK7 ALA A 541 ? UNP P19821 ?   ?   'expression tag' 834 11 
1 8XK7 LYS A 542 ? UNP P19821 ?   ?   'expression tag' 835 12 
1 8XK7 LEU A 543 ? UNP P19821 ?   ?   'expression tag' 836 13 
1 8XK7 ALA A 544 ? UNP P19821 ?   ?   'expression tag' 837 14 
1 8XK7 ALA A 545 ? UNP P19821 ?   ?   'expression tag' 838 15 
1 8XK7 ALA A 546 ? UNP P19821 ?   ?   'expression tag' 839 16 
1 8XK7 LEU A 547 ? UNP P19821 ?   ?   'expression tag' 840 17 
1 8XK7 GLU A 548 ? UNP P19821 ?   ?   'expression tag' 841 18 
1 8XK7 HIS A 549 ? UNP P19821 ?   ?   'expression tag' 842 19 
1 8XK7 HIS A 550 ? UNP P19821 ?   ?   'expression tag' 843 20 
1 8XK7 HIS A 551 ? UNP P19821 ?   ?   'expression tag' 844 21 
1 8XK7 HIS A 552 ? UNP P19821 ?   ?   'expression tag' 845 22 
1 8XK7 HIS A 553 ? UNP P19821 ?   ?   'expression tag' 846 23 
1 8XK7 HIS A 554 ? UNP P19821 ?   ?   'expression tag' 847 24 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 7160  ? 
1 MORE         -55   ? 
1 'SSA (A^2)'  26340 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 44  ? LEU A 49  ? GLU A 337 LEU A 342 1 ? 6  
HELX_P HELX_P2  AA2 ARG A 50  ? LEU A 52  ? ARG A 343 LEU A 345 5 ? 3  
HELX_P HELX_P3  AA3 LEU A 59  ? GLU A 70  ? LEU A 352 GLU A 363 1 ? 12 
HELX_P HELX_P4  AA4 ASP A 79  ? ASP A 88  ? ASP A 372 ASP A 381 1 ? 10 
HELX_P HELX_P5  AA5 THR A 93  ? GLY A 102 ? THR A 386 GLY A 395 1 ? 10 
HELX_P HELX_P6  AA6 GLU A 108 ? LEU A 127 ? GLU A 401 LEU A 420 1 ? 20 
HELX_P HELX_P7  AA7 GLU A 130 ? VAL A 140 ? GLU A 423 VAL A 433 1 ? 11 
HELX_P HELX_P8  AA8 VAL A 140 ? GLY A 155 ? VAL A 433 GLY A 448 1 ? 16 
HELX_P HELX_P9  AA9 ASP A 159 ? GLY A 186 ? ASP A 452 GLY A 479 1 ? 28 
HELX_P HELX_P10 AB1 SER A 193 ? ASP A 203 ? SER A 486 ASP A 496 1 ? 11 
HELX_P HELX_P11 AB2 SER A 222 ? GLU A 227 ? SER A 515 GLU A 520 1 ? 6  
HELX_P HELX_P12 AB3 ALA A 228 ? ARG A 230 ? ALA A 521 ARG A 523 5 ? 3  
HELX_P HELX_P13 AB4 HIS A 233 ? TYR A 252 ? HIS A 526 TYR A 545 1 ? 20 
HELX_P HELX_P14 AB5 PRO A 255 ? ILE A 260 ? PRO A 548 ILE A 553 5 ? 6  
HELX_P HELX_P15 AB6 THR A 295 ? ARG A 303 ? THR A 588 ARG A 596 1 ? 9  
HELX_P HELX_P16 AB7 GLN A 320 ? GLY A 331 ? GLN A 613 GLY A 624 1 ? 12 
HELX_P HELX_P17 AB8 ASP A 332 ? GLU A 341 ? ASP A 625 GLU A 634 1 ? 10 
HELX_P HELX_P18 AB9 ASP A 344 ? PHE A 354 ? ASP A 637 PHE A 647 1 ? 11 
HELX_P HELX_P19 AC1 PRO A 357 ? VAL A 361 ? PRO A 650 VAL A 654 5 ? 5  
HELX_P HELX_P20 AC2 ASN A 362 ? VAL A 376 ? ASN A 655 VAL A 669 1 ? 15 
HELX_P HELX_P21 AC3 LEU A 377 ? GLY A 379 ? LEU A 670 GLY A 672 5 ? 3  
HELX_P HELX_P22 AC4 SER A 381 ? ALA A 390 ? SER A 674 ALA A 683 1 ? 10 
HELX_P HELX_P23 AC5 PRO A 392 ? PHE A 407 ? PRO A 685 PHE A 700 1 ? 16 
HELX_P HELX_P24 AC6 PHE A 407 ? GLY A 425 ? PHE A 700 GLY A 718 1 ? 19 
HELX_P HELX_P25 AC7 VAL A 444 ? MET A 482 ? VAL A 737 MET A 775 1 ? 39 
HELX_P HELX_P26 AC8 ARG A 502 ? GLY A 516 ? ARG A 795 GLY A 809 1 ? 15 
HELX_P HELX_P27 AC9 ASP A 533 ? ALA A 546 ? ASP A 826 ALA A 839 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? B DC 16 "O3'" ? ? ? 1_555 B OMG 17 P  ? ? B DC 217 B OMG 218 1_555 ? ? ? ? ? ? ?            1.610 ? ? 
covale2  covale both ? C DC 12 "O3'" ? ? ? 1_555 C OMG 13 P  ? ? C DC 111 C OMG 112 1_555 ? ? ? ? ? ? ?            1.607 ? ? 
hydrog1  hydrog ?    ? B DC 4  N3    ? ? ? 1_555 C OMG 13 N1 ? ? B DC 205 C OMG 112 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog2  hydrog ?    ? B DC 4  N4    ? ? ? 1_555 C OMG 13 O6 ? ? B DC 205 C OMG 112 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ?    ? B DC 4  O2    ? ? ? 1_555 C OMG 13 N2 ? ? B DC 205 C OMG 112 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ?    ? B DG 5  N1    ? ? ? 1_555 C DC  12 N3 ? ? B DG 206 C DC  111 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ?    ? B DG 5  N2    ? ? ? 1_555 C DC  12 O2 ? ? B DG 206 C DC  111 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ?    ? B DG 5  O6    ? ? ? 1_555 C DC  12 N4 ? ? B DG 206 C DC  111 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ?    ? B DG 6  N1    ? ? ? 1_555 C DC  11 N3 ? ? B DG 207 C DC  110 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ?    ? B DG 6  N2    ? ? ? 1_555 C DC  11 O2 ? ? B DG 207 C DC  110 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ?    ? B DG 6  O6    ? ? ? 1_555 C DC  11 N4 ? ? B DG 207 C DC  110 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ?    ? B DC 7  N3    ? ? ? 1_555 C DG  10 N1 ? ? B DC 208 C DG  109 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ?    ? B DC 7  N4    ? ? ? 1_555 C DG  10 O6 ? ? B DC 208 C DG  109 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ?    ? B DC 7  O2    ? ? ? 1_555 C DG  10 N2 ? ? B DC 208 C DG  109 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ?    ? B DG 8  N1    ? ? ? 1_555 C DC  9  N3 ? ? B DG 209 C DC  108 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog14 hydrog ?    ? B DG 8  N2    ? ? ? 1_555 C DC  9  O2 ? ? B DG 209 C DC  108 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ?    ? B DG 8  O6    ? ? ? 1_555 C DC  9  N4 ? ? B DG 209 C DC  108 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ?    ? B DC 9  N3    ? ? ? 1_555 C DG  8  N1 ? ? B DC 210 C DG  107 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog17 hydrog ?    ? B DC 9  N4    ? ? ? 1_555 C DG  8  O6 ? ? B DC 210 C DG  107 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog18 hydrog ?    ? B DC 9  O2    ? ? ? 1_555 C DG  8  N2 ? ? B DC 210 C DG  107 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog19 hydrog ?    ? B DC 10 N3    ? ? ? 1_555 C DG  7  N1 ? ? B DC 211 C DG  106 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog20 hydrog ?    ? B DC 10 N4    ? ? ? 1_555 C DG  7  O6 ? ? B DC 211 C DG  106 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog21 hydrog ?    ? B DC 10 O2    ? ? ? 1_555 C DG  7  N2 ? ? B DC 211 C DG  106 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog22 hydrog ?    ? B DG 11 N1    ? ? ? 1_555 C DC  6  N3 ? ? B DG 212 C DC  105 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog23 hydrog ?    ? B DG 11 N2    ? ? ? 1_555 C DC  6  O2 ? ? B DG 212 C DC  105 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog24 hydrog ?    ? B DG 11 O6    ? ? ? 1_555 C DC  6  N4 ? ? B DG 212 C DC  105 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog25 hydrog ?    ? B DT 12 N3    ? ? ? 1_555 C DA  5  N1 ? ? B DT 213 C DA  104 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog26 hydrog ?    ? B DT 12 O4    ? ? ? 1_555 C DA  5  N6 ? ? B DT 213 C DA  104 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog27 hydrog ?    ? B DG 13 N1    ? ? ? 1_555 C DC  4  N3 ? ? B DG 214 C DC  103 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog28 hydrog ?    ? B DG 13 N2    ? ? ? 1_555 C DC  4  O2 ? ? B DG 214 C DC  103 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog29 hydrog ?    ? B DG 13 O6    ? ? ? 1_555 C DC  4  N4 ? ? B DG 214 C DC  103 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog30 hydrog ?    ? B DG 14 N1    ? ? ? 1_555 C DC  3  N3 ? ? B DG 215 C DC  102 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog31 hydrog ?    ? B DG 14 N2    ? ? ? 1_555 C DC  3  O2 ? ? B DG 215 C DC  102 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog32 hydrog ?    ? B DG 14 O6    ? ? ? 1_555 C DC  3  N4 ? ? B DG 215 C DC  102 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog33 hydrog ?    ? B DT 15 N3    ? ? ? 1_555 C DA  2  N1 ? ? B DT 216 C DA  101 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog34 hydrog ?    ? B DT 15 O4    ? ? ? 1_555 C DA  2  N6 ? ? B DT 216 C DA  101 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog35 hydrog ?    ? B DC 16 N3    ? ? ? 1_555 C DG  1  N1 ? ? B DC 217 C DG  100 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog36 hydrog ?    ? B DC 16 N4    ? ? ? 1_555 C DG  1  O6 ? ? B DC 217 C DG  100 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog37 hydrog ?    ? B DC 16 O2    ? ? ? 1_555 C DG  1  N2 ? ? B DC 217 C DG  100 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
hydrog ? ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TRP 6   A . ? TRP 299 A PRO 7   A ? PRO 300 A 1 0.79  
2 ASP 285 A . ? ASP 578 A PRO 286 A ? PRO 579 A 1 -1.67 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 4   ? PRO A 5   ? ALA A 297 PRO A 298 
AA1 2 ARG A 38  ? ARG A 41  ? ARG A 331 ARG A 334 
AA1 3 LEU A 28  ? ARG A 35  ? LEU A 321 ARG A 328 
AA1 4 PHE A 13  ? LEU A 18  ? PHE A 306 LEU A 311 
AA2 1 ARG A 157 ? LEU A 158 ? ARG A 450 LEU A 451 
AA2 2 PHE A 305 ? ILE A 306 ? PHE A 598 ILE A 599 
AA3 1 ARG A 270 ? ASN A 272 ? ARG A 563 ASN A 565 
AA3 2 SER A 282 ? SER A 284 ? SER A 575 SER A 577 
AA4 1 ARG A 485 ? GLN A 489 ? ARG A 778 GLN A 782 
AA4 2 GLU A 493 ? PRO A 499 ? GLU A 786 PRO A 792 
AA4 3 TRP A 311 ? TYR A 318 ? TRP A 604 TYR A 611 
AA4 4 VAL A 526 ? GLY A 531 ? VAL A 819 GLY A 824 
AA5 1 TYR A 426 ? GLU A 428 ? TYR A 719 GLU A 721 
AA5 2 ARG A 434 ? TYR A 436 ? ARG A 727 TYR A 729 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 4   ? N ALA A 297 O VAL A 39  ? O VAL A 332 
AA1 2 3 O HIS A 40  ? O HIS A 333 N ALA A 33  ? N ALA A 326 
AA1 3 4 O ALA A 34  ? O ALA A 327 N PHE A 13  ? N PHE A 306 
AA2 1 2 N ARG A 157 ? N ARG A 450 O ILE A 306 ? O ILE A 599 
AA3 1 2 N ARG A 270 ? N ARG A 563 O SER A 284 ? O SER A 577 
AA4 1 2 N ARG A 485 ? N ARG A 778 O GLU A 497 ? O GLU A 790 
AA4 2 3 O LEU A 496 ? O LEU A 789 N VAL A 314 ? N VAL A 607 
AA4 3 4 N LEU A 313 ? N LEU A 606 O GLY A 531 ? O GLY A 824 
AA5 1 2 N VAL A 427 ? N VAL A 720 O ARG A 435 ? O ARG A 728 
# 
_pdbx_entry_details.entry_id                   8XK7 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    578 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    1001 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 OP1   B DA 203 ? ? P     B DA 203 ? ? OP2 B DA 203 ? ? 129.66 119.60 10.06 1.50 N 
2 1 "O5'" B DA 203 ? ? P     B DA 203 ? ? OP2 B DA 203 ? ? 100.09 105.70 -5.61 0.90 N 
3 1 "O4'" B DA 203 ? ? "C1'" B DA 203 ? ? N9  B DA 203 ? ? 110.34 108.30 2.04  0.30 N 
4 1 "O4'" B DG 206 ? ? "C1'" B DG 206 ? ? N9  B DG 206 ? ? 112.14 108.30 3.84  0.30 N 
5 1 "O4'" C DG 109 ? ? "C1'" C DG 109 ? ? N9  C DG 109 ? ? 111.33 108.30 3.03  0.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 381 ? ? -163.22 108.52  
2 1 THR A 399 ? ? -115.33 -165.77 
3 1 VAL A 433 ? ? -121.54 -69.64  
4 1 ASP A 496 ? ? -94.60  -69.84  
5 1 TYR A 545 ? ? -125.68 -57.97  
6 1 VAL A 586 ? ? -154.63 -23.05  
7 1 MET A 673 ? ? 63.41   70.59   
8 1 HIS A 784 ? ? 68.31   -69.65  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 457 ? ? 0.083 'SIDE CHAIN' 
2 1 ARG A 469 ? ? 0.177 'SIDE CHAIN' 
3 1 ARG A 476 ? ? 0.094 'SIDE CHAIN' 
4 1 ARG A 630 ? ? 0.083 'SIDE CHAIN' 
5 1 ARG A 677 ? ? 0.167 'SIDE CHAIN' 
6 1 ARG A 741 ? ? 0.210 'SIDE CHAIN' 
7 1 ARG A 747 ? ? 0.118 'SIDE CHAIN' 
8 1 ARG A 795 ? ? 0.082 'SIDE CHAIN' 
9 1 ARG A 801 ? ? 0.085 'SIDE CHAIN' 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1272 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.29 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 294 ? A MET 1   
2 1 Y 1 A GLU 295 ? A GLU 2   
3 1 Y 1 A HIS 842 ? A HIS 549 
4 1 Y 1 A HIS 843 ? A HIS 550 
5 1 Y 1 A HIS 844 ? A HIS 551 
6 1 Y 1 A HIS 845 ? A HIS 552 
7 1 Y 1 A HIS 846 ? A HIS 553 
8 1 Y 1 A HIS 847 ? A HIS 554 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
DA  OP3    O N N 74  
DA  P      P N N 75  
DA  OP1    O N N 76  
DA  OP2    O N N 77  
DA  "O5'"  O N N 78  
DA  "C5'"  C N N 79  
DA  "C4'"  C N R 80  
DA  "O4'"  O N N 81  
DA  "C3'"  C N S 82  
DA  "O3'"  O N N 83  
DA  "C2'"  C N N 84  
DA  "C1'"  C N R 85  
DA  N9     N Y N 86  
DA  C8     C Y N 87  
DA  N7     N Y N 88  
DA  C5     C Y N 89  
DA  C6     C Y N 90  
DA  N6     N N N 91  
DA  N1     N Y N 92  
DA  C2     C Y N 93  
DA  N3     N Y N 94  
DA  C4     C Y N 95  
DA  HOP3   H N N 96  
DA  HOP2   H N N 97  
DA  "H5'"  H N N 98  
DA  "H5''" H N N 99  
DA  "H4'"  H N N 100 
DA  "H3'"  H N N 101 
DA  "HO3'" H N N 102 
DA  "H2'"  H N N 103 
DA  "H2''" H N N 104 
DA  "H1'"  H N N 105 
DA  H8     H N N 106 
DA  H61    H N N 107 
DA  H62    H N N 108 
DA  H2     H N N 109 
DC  OP3    O N N 110 
DC  P      P N N 111 
DC  OP1    O N N 112 
DC  OP2    O N N 113 
DC  "O5'"  O N N 114 
DC  "C5'"  C N N 115 
DC  "C4'"  C N R 116 
DC  "O4'"  O N N 117 
DC  "C3'"  C N S 118 
DC  "O3'"  O N N 119 
DC  "C2'"  C N N 120 
DC  "C1'"  C N R 121 
DC  N1     N N N 122 
DC  C2     C N N 123 
DC  O2     O N N 124 
DC  N3     N N N 125 
DC  C4     C N N 126 
DC  N4     N N N 127 
DC  C5     C N N 128 
DC  C6     C N N 129 
DC  HOP3   H N N 130 
DC  HOP2   H N N 131 
DC  "H5'"  H N N 132 
DC  "H5''" H N N 133 
DC  "H4'"  H N N 134 
DC  "H3'"  H N N 135 
DC  "HO3'" H N N 136 
DC  "H2'"  H N N 137 
DC  "H2''" H N N 138 
DC  "H1'"  H N N 139 
DC  H41    H N N 140 
DC  H42    H N N 141 
DC  H5     H N N 142 
DC  H6     H N N 143 
DG  OP3    O N N 144 
DG  P      P N N 145 
DG  OP1    O N N 146 
DG  OP2    O N N 147 
DG  "O5'"  O N N 148 
DG  "C5'"  C N N 149 
DG  "C4'"  C N R 150 
DG  "O4'"  O N N 151 
DG  "C3'"  C N S 152 
DG  "O3'"  O N N 153 
DG  "C2'"  C N N 154 
DG  "C1'"  C N R 155 
DG  N9     N Y N 156 
DG  C8     C Y N 157 
DG  N7     N Y N 158 
DG  C5     C Y N 159 
DG  C6     C N N 160 
DG  O6     O N N 161 
DG  N1     N N N 162 
DG  C2     C N N 163 
DG  N2     N N N 164 
DG  N3     N N N 165 
DG  C4     C Y N 166 
DG  HOP3   H N N 167 
DG  HOP2   H N N 168 
DG  "H5'"  H N N 169 
DG  "H5''" H N N 170 
DG  "H4'"  H N N 171 
DG  "H3'"  H N N 172 
DG  "HO3'" H N N 173 
DG  "H2'"  H N N 174 
DG  "H2''" H N N 175 
DG  "H1'"  H N N 176 
DG  H8     H N N 177 
DG  H1     H N N 178 
DG  H21    H N N 179 
DG  H22    H N N 180 
DT  OP3    O N N 181 
DT  P      P N N 182 
DT  OP1    O N N 183 
DT  OP2    O N N 184 
DT  "O5'"  O N N 185 
DT  "C5'"  C N N 186 
DT  "C4'"  C N R 187 
DT  "O4'"  O N N 188 
DT  "C3'"  C N S 189 
DT  "O3'"  O N N 190 
DT  "C2'"  C N N 191 
DT  "C1'"  C N R 192 
DT  N1     N N N 193 
DT  C2     C N N 194 
DT  O2     O N N 195 
DT  N3     N N N 196 
DT  C4     C N N 197 
DT  O4     O N N 198 
DT  C5     C N N 199 
DT  C7     C N N 200 
DT  C6     C N N 201 
DT  HOP3   H N N 202 
DT  HOP2   H N N 203 
DT  "H5'"  H N N 204 
DT  "H5''" H N N 205 
DT  "H4'"  H N N 206 
DT  "H3'"  H N N 207 
DT  "HO3'" H N N 208 
DT  "H2'"  H N N 209 
DT  "H2''" H N N 210 
DT  "H1'"  H N N 211 
DT  H3     H N N 212 
DT  H71    H N N 213 
DT  H72    H N N 214 
DT  H73    H N N 215 
DT  H6     H N N 216 
GLN N      N N N 217 
GLN CA     C N S 218 
GLN C      C N N 219 
GLN O      O N N 220 
GLN CB     C N N 221 
GLN CG     C N N 222 
GLN CD     C N N 223 
GLN OE1    O N N 224 
GLN NE2    N N N 225 
GLN OXT    O N N 226 
GLN H      H N N 227 
GLN H2     H N N 228 
GLN HA     H N N 229 
GLN HB2    H N N 230 
GLN HB3    H N N 231 
GLN HG2    H N N 232 
GLN HG3    H N N 233 
GLN HE21   H N N 234 
GLN HE22   H N N 235 
GLN HXT    H N N 236 
GLU N      N N N 237 
GLU CA     C N S 238 
GLU C      C N N 239 
GLU O      O N N 240 
GLU CB     C N N 241 
GLU CG     C N N 242 
GLU CD     C N N 243 
GLU OE1    O N N 244 
GLU OE2    O N N 245 
GLU OXT    O N N 246 
GLU H      H N N 247 
GLU H2     H N N 248 
GLU HA     H N N 249 
GLU HB2    H N N 250 
GLU HB3    H N N 251 
GLU HG2    H N N 252 
GLU HG3    H N N 253 
GLU HE2    H N N 254 
GLU HXT    H N N 255 
GLY N      N N N 256 
GLY CA     C N N 257 
GLY C      C N N 258 
GLY O      O N N 259 
GLY OXT    O N N 260 
GLY H      H N N 261 
GLY H2     H N N 262 
GLY HA2    H N N 263 
GLY HA3    H N N 264 
GLY HXT    H N N 265 
HIS N      N N N 266 
HIS CA     C N S 267 
HIS C      C N N 268 
HIS O      O N N 269 
HIS CB     C N N 270 
HIS CG     C Y N 271 
HIS ND1    N Y N 272 
HIS CD2    C Y N 273 
HIS CE1    C Y N 274 
HIS NE2    N Y N 275 
HIS OXT    O N N 276 
HIS H      H N N 277 
HIS H2     H N N 278 
HIS HA     H N N 279 
HIS HB2    H N N 280 
HIS HB3    H N N 281 
HIS HD1    H N N 282 
HIS HD2    H N N 283 
HIS HE1    H N N 284 
HIS HE2    H N N 285 
HIS HXT    H N N 286 
HOH O      O N N 287 
HOH H1     H N N 288 
HOH H2     H N N 289 
ILE N      N N N 290 
ILE CA     C N S 291 
ILE C      C N N 292 
ILE O      O N N 293 
ILE CB     C N S 294 
ILE CG1    C N N 295 
ILE CG2    C N N 296 
ILE CD1    C N N 297 
ILE OXT    O N N 298 
ILE H      H N N 299 
ILE H2     H N N 300 
ILE HA     H N N 301 
ILE HB     H N N 302 
ILE HG12   H N N 303 
ILE HG13   H N N 304 
ILE HG21   H N N 305 
ILE HG22   H N N 306 
ILE HG23   H N N 307 
ILE HD11   H N N 308 
ILE HD12   H N N 309 
ILE HD13   H N N 310 
ILE HXT    H N N 311 
LEU N      N N N 312 
LEU CA     C N S 313 
LEU C      C N N 314 
LEU O      O N N 315 
LEU CB     C N N 316 
LEU CG     C N N 317 
LEU CD1    C N N 318 
LEU CD2    C N N 319 
LEU OXT    O N N 320 
LEU H      H N N 321 
LEU H2     H N N 322 
LEU HA     H N N 323 
LEU HB2    H N N 324 
LEU HB3    H N N 325 
LEU HG     H N N 326 
LEU HD11   H N N 327 
LEU HD12   H N N 328 
LEU HD13   H N N 329 
LEU HD21   H N N 330 
LEU HD22   H N N 331 
LEU HD23   H N N 332 
LEU HXT    H N N 333 
LYS N      N N N 334 
LYS CA     C N S 335 
LYS C      C N N 336 
LYS O      O N N 337 
LYS CB     C N N 338 
LYS CG     C N N 339 
LYS CD     C N N 340 
LYS CE     C N N 341 
LYS NZ     N N N 342 
LYS OXT    O N N 343 
LYS H      H N N 344 
LYS H2     H N N 345 
LYS HA     H N N 346 
LYS HB2    H N N 347 
LYS HB3    H N N 348 
LYS HG2    H N N 349 
LYS HG3    H N N 350 
LYS HD2    H N N 351 
LYS HD3    H N N 352 
LYS HE2    H N N 353 
LYS HE3    H N N 354 
LYS HZ1    H N N 355 
LYS HZ2    H N N 356 
LYS HZ3    H N N 357 
LYS HXT    H N N 358 
MET N      N N N 359 
MET CA     C N S 360 
MET C      C N N 361 
MET O      O N N 362 
MET CB     C N N 363 
MET CG     C N N 364 
MET SD     S N N 365 
MET CE     C N N 366 
MET OXT    O N N 367 
MET H      H N N 368 
MET H2     H N N 369 
MET HA     H N N 370 
MET HB2    H N N 371 
MET HB3    H N N 372 
MET HG2    H N N 373 
MET HG3    H N N 374 
MET HE1    H N N 375 
MET HE2    H N N 376 
MET HE3    H N N 377 
MET HXT    H N N 378 
OMG P      P N N 379 
OMG OP1    O N N 380 
OMG OP2    O N N 381 
OMG OP3    O N N 382 
OMG "O5'"  O N N 383 
OMG "C5'"  C N N 384 
OMG "C4'"  C N R 385 
OMG "O4'"  O N N 386 
OMG "C3'"  C N R 387 
OMG "O3'"  O N N 388 
OMG "C2'"  C N R 389 
OMG "O2'"  O N N 390 
OMG CM2    C N N 391 
OMG "C1'"  C N R 392 
OMG N9     N Y N 393 
OMG C8     C Y N 394 
OMG N7     N Y N 395 
OMG C5     C Y N 396 
OMG C6     C N N 397 
OMG O6     O N N 398 
OMG N1     N N N 399 
OMG C2     C N N 400 
OMG N2     N N N 401 
OMG N3     N N N 402 
OMG C4     C Y N 403 
OMG HOP2   H N N 404 
OMG HOP3   H N N 405 
OMG "H5'"  H N N 406 
OMG "H5''" H N N 407 
OMG "H4'"  H N N 408 
OMG "H3'"  H N N 409 
OMG "HO3'" H N N 410 
OMG "H2'"  H N N 411 
OMG HM21   H N N 412 
OMG HM22   H N N 413 
OMG HM23   H N N 414 
OMG "H1'"  H N N 415 
OMG H8     H N N 416 
OMG HN1    H N N 417 
OMG HN21   H N N 418 
OMG HN22   H N N 419 
PEG C1     C N N 420 
PEG O1     O N N 421 
PEG C2     C N N 422 
PEG O2     O N N 423 
PEG C3     C N N 424 
PEG C4     C N N 425 
PEG O4     O N N 426 
PEG H11    H N N 427 
PEG H12    H N N 428 
PEG HO1    H N N 429 
PEG H21    H N N 430 
PEG H22    H N N 431 
PEG H31    H N N 432 
PEG H32    H N N 433 
PEG H41    H N N 434 
PEG H42    H N N 435 
PEG HO4    H N N 436 
PHE N      N N N 437 
PHE CA     C N S 438 
PHE C      C N N 439 
PHE O      O N N 440 
PHE CB     C N N 441 
PHE CG     C Y N 442 
PHE CD1    C Y N 443 
PHE CD2    C Y N 444 
PHE CE1    C Y N 445 
PHE CE2    C Y N 446 
PHE CZ     C Y N 447 
PHE OXT    O N N 448 
PHE H      H N N 449 
PHE H2     H N N 450 
PHE HA     H N N 451 
PHE HB2    H N N 452 
PHE HB3    H N N 453 
PHE HD1    H N N 454 
PHE HD2    H N N 455 
PHE HE1    H N N 456 
PHE HE2    H N N 457 
PHE HZ     H N N 458 
PHE HXT    H N N 459 
PO4 P      P N N 460 
PO4 O1     O N N 461 
PO4 O2     O N N 462 
PO4 O3     O N N 463 
PO4 O4     O N N 464 
PRO N      N N N 465 
PRO CA     C N S 466 
PRO C      C N N 467 
PRO O      O N N 468 
PRO CB     C N N 469 
PRO CG     C N N 470 
PRO CD     C N N 471 
PRO OXT    O N N 472 
PRO H      H N N 473 
PRO HA     H N N 474 
PRO HB2    H N N 475 
PRO HB3    H N N 476 
PRO HG2    H N N 477 
PRO HG3    H N N 478 
PRO HD2    H N N 479 
PRO HD3    H N N 480 
PRO HXT    H N N 481 
SER N      N N N 482 
SER CA     C N S 483 
SER C      C N N 484 
SER O      O N N 485 
SER CB     C N N 486 
SER OG     O N N 487 
SER OXT    O N N 488 
SER H      H N N 489 
SER H2     H N N 490 
SER HA     H N N 491 
SER HB2    H N N 492 
SER HB3    H N N 493 
SER HG     H N N 494 
SER HXT    H N N 495 
SO4 S      S N N 496 
SO4 O1     O N N 497 
SO4 O2     O N N 498 
SO4 O3     O N N 499 
SO4 O4     O N N 500 
THR N      N N N 501 
THR CA     C N S 502 
THR C      C N N 503 
THR O      O N N 504 
THR CB     C N R 505 
THR OG1    O N N 506 
THR CG2    C N N 507 
THR OXT    O N N 508 
THR H      H N N 509 
THR H2     H N N 510 
THR HA     H N N 511 
THR HB     H N N 512 
THR HG1    H N N 513 
THR HG21   H N N 514 
THR HG22   H N N 515 
THR HG23   H N N 516 
THR HXT    H N N 517 
TRP N      N N N 518 
TRP CA     C N S 519 
TRP C      C N N 520 
TRP O      O N N 521 
TRP CB     C N N 522 
TRP CG     C Y N 523 
TRP CD1    C Y N 524 
TRP CD2    C Y N 525 
TRP NE1    N Y N 526 
TRP CE2    C Y N 527 
TRP CE3    C Y N 528 
TRP CZ2    C Y N 529 
TRP CZ3    C Y N 530 
TRP CH2    C Y N 531 
TRP OXT    O N N 532 
TRP H      H N N 533 
TRP H2     H N N 534 
TRP HA     H N N 535 
TRP HB2    H N N 536 
TRP HB3    H N N 537 
TRP HD1    H N N 538 
TRP HE1    H N N 539 
TRP HE3    H N N 540 
TRP HZ2    H N N 541 
TRP HZ3    H N N 542 
TRP HH2    H N N 543 
TRP HXT    H N N 544 
TYR N      N N N 545 
TYR CA     C N S 546 
TYR C      C N N 547 
TYR O      O N N 548 
TYR CB     C N N 549 
TYR CG     C Y N 550 
TYR CD1    C Y N 551 
TYR CD2    C Y N 552 
TYR CE1    C Y N 553 
TYR CE2    C Y N 554 
TYR CZ     C Y N 555 
TYR OH     O N N 556 
TYR OXT    O N N 557 
TYR H      H N N 558 
TYR H2     H N N 559 
TYR HA     H N N 560 
TYR HB2    H N N 561 
TYR HB3    H N N 562 
TYR HD1    H N N 563 
TYR HD2    H N N 564 
TYR HE1    H N N 565 
TYR HE2    H N N 566 
TYR HH     H N N 567 
TYR HXT    H N N 568 
VAL N      N N N 569 
VAL CA     C N S 570 
VAL C      C N N 571 
VAL O      O N N 572 
VAL CB     C N N 573 
VAL CG1    C N N 574 
VAL CG2    C N N 575 
VAL OXT    O N N 576 
VAL H      H N N 577 
VAL H2     H N N 578 
VAL HA     H N N 579 
VAL HB     H N N 580 
VAL HG11   H N N 581 
VAL HG12   H N N 582 
VAL HG13   H N N 583 
VAL HG21   H N N 584 
VAL HG22   H N N 585 
VAL HG23   H N N 586 
VAL HXT    H N N 587 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
DA  OP3   P      sing N N 70  
DA  OP3   HOP3   sing N N 71  
DA  P     OP1    doub N N 72  
DA  P     OP2    sing N N 73  
DA  P     "O5'"  sing N N 74  
DA  OP2   HOP2   sing N N 75  
DA  "O5'" "C5'"  sing N N 76  
DA  "C5'" "C4'"  sing N N 77  
DA  "C5'" "H5'"  sing N N 78  
DA  "C5'" "H5''" sing N N 79  
DA  "C4'" "O4'"  sing N N 80  
DA  "C4'" "C3'"  sing N N 81  
DA  "C4'" "H4'"  sing N N 82  
DA  "O4'" "C1'"  sing N N 83  
DA  "C3'" "O3'"  sing N N 84  
DA  "C3'" "C2'"  sing N N 85  
DA  "C3'" "H3'"  sing N N 86  
DA  "O3'" "HO3'" sing N N 87  
DA  "C2'" "C1'"  sing N N 88  
DA  "C2'" "H2'"  sing N N 89  
DA  "C2'" "H2''" sing N N 90  
DA  "C1'" N9     sing N N 91  
DA  "C1'" "H1'"  sing N N 92  
DA  N9    C8     sing Y N 93  
DA  N9    C4     sing Y N 94  
DA  C8    N7     doub Y N 95  
DA  C8    H8     sing N N 96  
DA  N7    C5     sing Y N 97  
DA  C5    C6     sing Y N 98  
DA  C5    C4     doub Y N 99  
DA  C6    N6     sing N N 100 
DA  C6    N1     doub Y N 101 
DA  N6    H61    sing N N 102 
DA  N6    H62    sing N N 103 
DA  N1    C2     sing Y N 104 
DA  C2    N3     doub Y N 105 
DA  C2    H2     sing N N 106 
DA  N3    C4     sing Y N 107 
DC  OP3   P      sing N N 108 
DC  OP3   HOP3   sing N N 109 
DC  P     OP1    doub N N 110 
DC  P     OP2    sing N N 111 
DC  P     "O5'"  sing N N 112 
DC  OP2   HOP2   sing N N 113 
DC  "O5'" "C5'"  sing N N 114 
DC  "C5'" "C4'"  sing N N 115 
DC  "C5'" "H5'"  sing N N 116 
DC  "C5'" "H5''" sing N N 117 
DC  "C4'" "O4'"  sing N N 118 
DC  "C4'" "C3'"  sing N N 119 
DC  "C4'" "H4'"  sing N N 120 
DC  "O4'" "C1'"  sing N N 121 
DC  "C3'" "O3'"  sing N N 122 
DC  "C3'" "C2'"  sing N N 123 
DC  "C3'" "H3'"  sing N N 124 
DC  "O3'" "HO3'" sing N N 125 
DC  "C2'" "C1'"  sing N N 126 
DC  "C2'" "H2'"  sing N N 127 
DC  "C2'" "H2''" sing N N 128 
DC  "C1'" N1     sing N N 129 
DC  "C1'" "H1'"  sing N N 130 
DC  N1    C2     sing N N 131 
DC  N1    C6     sing N N 132 
DC  C2    O2     doub N N 133 
DC  C2    N3     sing N N 134 
DC  N3    C4     doub N N 135 
DC  C4    N4     sing N N 136 
DC  C4    C5     sing N N 137 
DC  N4    H41    sing N N 138 
DC  N4    H42    sing N N 139 
DC  C5    C6     doub N N 140 
DC  C5    H5     sing N N 141 
DC  C6    H6     sing N N 142 
DG  OP3   P      sing N N 143 
DG  OP3   HOP3   sing N N 144 
DG  P     OP1    doub N N 145 
DG  P     OP2    sing N N 146 
DG  P     "O5'"  sing N N 147 
DG  OP2   HOP2   sing N N 148 
DG  "O5'" "C5'"  sing N N 149 
DG  "C5'" "C4'"  sing N N 150 
DG  "C5'" "H5'"  sing N N 151 
DG  "C5'" "H5''" sing N N 152 
DG  "C4'" "O4'"  sing N N 153 
DG  "C4'" "C3'"  sing N N 154 
DG  "C4'" "H4'"  sing N N 155 
DG  "O4'" "C1'"  sing N N 156 
DG  "C3'" "O3'"  sing N N 157 
DG  "C3'" "C2'"  sing N N 158 
DG  "C3'" "H3'"  sing N N 159 
DG  "O3'" "HO3'" sing N N 160 
DG  "C2'" "C1'"  sing N N 161 
DG  "C2'" "H2'"  sing N N 162 
DG  "C2'" "H2''" sing N N 163 
DG  "C1'" N9     sing N N 164 
DG  "C1'" "H1'"  sing N N 165 
DG  N9    C8     sing Y N 166 
DG  N9    C4     sing Y N 167 
DG  C8    N7     doub Y N 168 
DG  C8    H8     sing N N 169 
DG  N7    C5     sing Y N 170 
DG  C5    C6     sing N N 171 
DG  C5    C4     doub Y N 172 
DG  C6    O6     doub N N 173 
DG  C6    N1     sing N N 174 
DG  N1    C2     sing N N 175 
DG  N1    H1     sing N N 176 
DG  C2    N2     sing N N 177 
DG  C2    N3     doub N N 178 
DG  N2    H21    sing N N 179 
DG  N2    H22    sing N N 180 
DG  N3    C4     sing N N 181 
DT  OP3   P      sing N N 182 
DT  OP3   HOP3   sing N N 183 
DT  P     OP1    doub N N 184 
DT  P     OP2    sing N N 185 
DT  P     "O5'"  sing N N 186 
DT  OP2   HOP2   sing N N 187 
DT  "O5'" "C5'"  sing N N 188 
DT  "C5'" "C4'"  sing N N 189 
DT  "C5'" "H5'"  sing N N 190 
DT  "C5'" "H5''" sing N N 191 
DT  "C4'" "O4'"  sing N N 192 
DT  "C4'" "C3'"  sing N N 193 
DT  "C4'" "H4'"  sing N N 194 
DT  "O4'" "C1'"  sing N N 195 
DT  "C3'" "O3'"  sing N N 196 
DT  "C3'" "C2'"  sing N N 197 
DT  "C3'" "H3'"  sing N N 198 
DT  "O3'" "HO3'" sing N N 199 
DT  "C2'" "C1'"  sing N N 200 
DT  "C2'" "H2'"  sing N N 201 
DT  "C2'" "H2''" sing N N 202 
DT  "C1'" N1     sing N N 203 
DT  "C1'" "H1'"  sing N N 204 
DT  N1    C2     sing N N 205 
DT  N1    C6     sing N N 206 
DT  C2    O2     doub N N 207 
DT  C2    N3     sing N N 208 
DT  N3    C4     sing N N 209 
DT  N3    H3     sing N N 210 
DT  C4    O4     doub N N 211 
DT  C4    C5     sing N N 212 
DT  C5    C7     sing N N 213 
DT  C5    C6     doub N N 214 
DT  C7    H71    sing N N 215 
DT  C7    H72    sing N N 216 
DT  C7    H73    sing N N 217 
DT  C6    H6     sing N N 218 
GLN N     CA     sing N N 219 
GLN N     H      sing N N 220 
GLN N     H2     sing N N 221 
GLN CA    C      sing N N 222 
GLN CA    CB     sing N N 223 
GLN CA    HA     sing N N 224 
GLN C     O      doub N N 225 
GLN C     OXT    sing N N 226 
GLN CB    CG     sing N N 227 
GLN CB    HB2    sing N N 228 
GLN CB    HB3    sing N N 229 
GLN CG    CD     sing N N 230 
GLN CG    HG2    sing N N 231 
GLN CG    HG3    sing N N 232 
GLN CD    OE1    doub N N 233 
GLN CD    NE2    sing N N 234 
GLN NE2   HE21   sing N N 235 
GLN NE2   HE22   sing N N 236 
GLN OXT   HXT    sing N N 237 
GLU N     CA     sing N N 238 
GLU N     H      sing N N 239 
GLU N     H2     sing N N 240 
GLU CA    C      sing N N 241 
GLU CA    CB     sing N N 242 
GLU CA    HA     sing N N 243 
GLU C     O      doub N N 244 
GLU C     OXT    sing N N 245 
GLU CB    CG     sing N N 246 
GLU CB    HB2    sing N N 247 
GLU CB    HB3    sing N N 248 
GLU CG    CD     sing N N 249 
GLU CG    HG2    sing N N 250 
GLU CG    HG3    sing N N 251 
GLU CD    OE1    doub N N 252 
GLU CD    OE2    sing N N 253 
GLU OE2   HE2    sing N N 254 
GLU OXT   HXT    sing N N 255 
GLY N     CA     sing N N 256 
GLY N     H      sing N N 257 
GLY N     H2     sing N N 258 
GLY CA    C      sing N N 259 
GLY CA    HA2    sing N N 260 
GLY CA    HA3    sing N N 261 
GLY C     O      doub N N 262 
GLY C     OXT    sing N N 263 
GLY OXT   HXT    sing N N 264 
HIS N     CA     sing N N 265 
HIS N     H      sing N N 266 
HIS N     H2     sing N N 267 
HIS CA    C      sing N N 268 
HIS CA    CB     sing N N 269 
HIS CA    HA     sing N N 270 
HIS C     O      doub N N 271 
HIS C     OXT    sing N N 272 
HIS CB    CG     sing N N 273 
HIS CB    HB2    sing N N 274 
HIS CB    HB3    sing N N 275 
HIS CG    ND1    sing Y N 276 
HIS CG    CD2    doub Y N 277 
HIS ND1   CE1    doub Y N 278 
HIS ND1   HD1    sing N N 279 
HIS CD2   NE2    sing Y N 280 
HIS CD2   HD2    sing N N 281 
HIS CE1   NE2    sing Y N 282 
HIS CE1   HE1    sing N N 283 
HIS NE2   HE2    sing N N 284 
HIS OXT   HXT    sing N N 285 
HOH O     H1     sing N N 286 
HOH O     H2     sing N N 287 
ILE N     CA     sing N N 288 
ILE N     H      sing N N 289 
ILE N     H2     sing N N 290 
ILE CA    C      sing N N 291 
ILE CA    CB     sing N N 292 
ILE CA    HA     sing N N 293 
ILE C     O      doub N N 294 
ILE C     OXT    sing N N 295 
ILE CB    CG1    sing N N 296 
ILE CB    CG2    sing N N 297 
ILE CB    HB     sing N N 298 
ILE CG1   CD1    sing N N 299 
ILE CG1   HG12   sing N N 300 
ILE CG1   HG13   sing N N 301 
ILE CG2   HG21   sing N N 302 
ILE CG2   HG22   sing N N 303 
ILE CG2   HG23   sing N N 304 
ILE CD1   HD11   sing N N 305 
ILE CD1   HD12   sing N N 306 
ILE CD1   HD13   sing N N 307 
ILE OXT   HXT    sing N N 308 
LEU N     CA     sing N N 309 
LEU N     H      sing N N 310 
LEU N     H2     sing N N 311 
LEU CA    C      sing N N 312 
LEU CA    CB     sing N N 313 
LEU CA    HA     sing N N 314 
LEU C     O      doub N N 315 
LEU C     OXT    sing N N 316 
LEU CB    CG     sing N N 317 
LEU CB    HB2    sing N N 318 
LEU CB    HB3    sing N N 319 
LEU CG    CD1    sing N N 320 
LEU CG    CD2    sing N N 321 
LEU CG    HG     sing N N 322 
LEU CD1   HD11   sing N N 323 
LEU CD1   HD12   sing N N 324 
LEU CD1   HD13   sing N N 325 
LEU CD2   HD21   sing N N 326 
LEU CD2   HD22   sing N N 327 
LEU CD2   HD23   sing N N 328 
LEU OXT   HXT    sing N N 329 
LYS N     CA     sing N N 330 
LYS N     H      sing N N 331 
LYS N     H2     sing N N 332 
LYS CA    C      sing N N 333 
LYS CA    CB     sing N N 334 
LYS CA    HA     sing N N 335 
LYS C     O      doub N N 336 
LYS C     OXT    sing N N 337 
LYS CB    CG     sing N N 338 
LYS CB    HB2    sing N N 339 
LYS CB    HB3    sing N N 340 
LYS CG    CD     sing N N 341 
LYS CG    HG2    sing N N 342 
LYS CG    HG3    sing N N 343 
LYS CD    CE     sing N N 344 
LYS CD    HD2    sing N N 345 
LYS CD    HD3    sing N N 346 
LYS CE    NZ     sing N N 347 
LYS CE    HE2    sing N N 348 
LYS CE    HE3    sing N N 349 
LYS NZ    HZ1    sing N N 350 
LYS NZ    HZ2    sing N N 351 
LYS NZ    HZ3    sing N N 352 
LYS OXT   HXT    sing N N 353 
MET N     CA     sing N N 354 
MET N     H      sing N N 355 
MET N     H2     sing N N 356 
MET CA    C      sing N N 357 
MET CA    CB     sing N N 358 
MET CA    HA     sing N N 359 
MET C     O      doub N N 360 
MET C     OXT    sing N N 361 
MET CB    CG     sing N N 362 
MET CB    HB2    sing N N 363 
MET CB    HB3    sing N N 364 
MET CG    SD     sing N N 365 
MET CG    HG2    sing N N 366 
MET CG    HG3    sing N N 367 
MET SD    CE     sing N N 368 
MET CE    HE1    sing N N 369 
MET CE    HE2    sing N N 370 
MET CE    HE3    sing N N 371 
MET OXT   HXT    sing N N 372 
OMG P     OP1    doub N N 373 
OMG P     OP2    sing N N 374 
OMG P     OP3    sing N N 375 
OMG P     "O5'"  sing N N 376 
OMG OP2   HOP2   sing N N 377 
OMG OP3   HOP3   sing N N 378 
OMG "O5'" "C5'"  sing N N 379 
OMG "C5'" "C4'"  sing N N 380 
OMG "C5'" "H5'"  sing N N 381 
OMG "C5'" "H5''" sing N N 382 
OMG "C4'" "O4'"  sing N N 383 
OMG "C4'" "C3'"  sing N N 384 
OMG "C4'" "H4'"  sing N N 385 
OMG "O4'" "C1'"  sing N N 386 
OMG "C3'" "O3'"  sing N N 387 
OMG "C3'" "C2'"  sing N N 388 
OMG "C3'" "H3'"  sing N N 389 
OMG "O3'" "HO3'" sing N N 390 
OMG "C2'" "O2'"  sing N N 391 
OMG "C2'" "C1'"  sing N N 392 
OMG "C2'" "H2'"  sing N N 393 
OMG "O2'" CM2    sing N N 394 
OMG CM2   HM21   sing N N 395 
OMG CM2   HM22   sing N N 396 
OMG CM2   HM23   sing N N 397 
OMG "C1'" N9     sing N N 398 
OMG "C1'" "H1'"  sing N N 399 
OMG N9    C8     sing Y N 400 
OMG N9    C4     sing Y N 401 
OMG C8    N7     doub Y N 402 
OMG C8    H8     sing N N 403 
OMG N7    C5     sing Y N 404 
OMG C5    C6     sing N N 405 
OMG C5    C4     doub Y N 406 
OMG C6    O6     doub N N 407 
OMG C6    N1     sing N N 408 
OMG N1    C2     sing N N 409 
OMG N1    HN1    sing N N 410 
OMG C2    N2     sing N N 411 
OMG C2    N3     doub N N 412 
OMG N2    HN21   sing N N 413 
OMG N2    HN22   sing N N 414 
OMG N3    C4     sing N N 415 
PEG C1    O1     sing N N 416 
PEG C1    C2     sing N N 417 
PEG C1    H11    sing N N 418 
PEG C1    H12    sing N N 419 
PEG O1    HO1    sing N N 420 
PEG C2    O2     sing N N 421 
PEG C2    H21    sing N N 422 
PEG C2    H22    sing N N 423 
PEG O2    C3     sing N N 424 
PEG C3    C4     sing N N 425 
PEG C3    H31    sing N N 426 
PEG C3    H32    sing N N 427 
PEG C4    O4     sing N N 428 
PEG C4    H41    sing N N 429 
PEG C4    H42    sing N N 430 
PEG O4    HO4    sing N N 431 
PHE N     CA     sing N N 432 
PHE N     H      sing N N 433 
PHE N     H2     sing N N 434 
PHE CA    C      sing N N 435 
PHE CA    CB     sing N N 436 
PHE CA    HA     sing N N 437 
PHE C     O      doub N N 438 
PHE C     OXT    sing N N 439 
PHE CB    CG     sing N N 440 
PHE CB    HB2    sing N N 441 
PHE CB    HB3    sing N N 442 
PHE CG    CD1    doub Y N 443 
PHE CG    CD2    sing Y N 444 
PHE CD1   CE1    sing Y N 445 
PHE CD1   HD1    sing N N 446 
PHE CD2   CE2    doub Y N 447 
PHE CD2   HD2    sing N N 448 
PHE CE1   CZ     doub Y N 449 
PHE CE1   HE1    sing N N 450 
PHE CE2   CZ     sing Y N 451 
PHE CE2   HE2    sing N N 452 
PHE CZ    HZ     sing N N 453 
PHE OXT   HXT    sing N N 454 
PO4 P     O1     doub N N 455 
PO4 P     O2     sing N N 456 
PO4 P     O3     sing N N 457 
PO4 P     O4     sing N N 458 
PRO N     CA     sing N N 459 
PRO N     CD     sing N N 460 
PRO N     H      sing N N 461 
PRO CA    C      sing N N 462 
PRO CA    CB     sing N N 463 
PRO CA    HA     sing N N 464 
PRO C     O      doub N N 465 
PRO C     OXT    sing N N 466 
PRO CB    CG     sing N N 467 
PRO CB    HB2    sing N N 468 
PRO CB    HB3    sing N N 469 
PRO CG    CD     sing N N 470 
PRO CG    HG2    sing N N 471 
PRO CG    HG3    sing N N 472 
PRO CD    HD2    sing N N 473 
PRO CD    HD3    sing N N 474 
PRO OXT   HXT    sing N N 475 
SER N     CA     sing N N 476 
SER N     H      sing N N 477 
SER N     H2     sing N N 478 
SER CA    C      sing N N 479 
SER CA    CB     sing N N 480 
SER CA    HA     sing N N 481 
SER C     O      doub N N 482 
SER C     OXT    sing N N 483 
SER CB    OG     sing N N 484 
SER CB    HB2    sing N N 485 
SER CB    HB3    sing N N 486 
SER OG    HG     sing N N 487 
SER OXT   HXT    sing N N 488 
SO4 S     O1     doub N N 489 
SO4 S     O2     doub N N 490 
SO4 S     O3     sing N N 491 
SO4 S     O4     sing N N 492 
THR N     CA     sing N N 493 
THR N     H      sing N N 494 
THR N     H2     sing N N 495 
THR CA    C      sing N N 496 
THR CA    CB     sing N N 497 
THR CA    HA     sing N N 498 
THR C     O      doub N N 499 
THR C     OXT    sing N N 500 
THR CB    OG1    sing N N 501 
THR CB    CG2    sing N N 502 
THR CB    HB     sing N N 503 
THR OG1   HG1    sing N N 504 
THR CG2   HG21   sing N N 505 
THR CG2   HG22   sing N N 506 
THR CG2   HG23   sing N N 507 
THR OXT   HXT    sing N N 508 
TRP N     CA     sing N N 509 
TRP N     H      sing N N 510 
TRP N     H2     sing N N 511 
TRP CA    C      sing N N 512 
TRP CA    CB     sing N N 513 
TRP CA    HA     sing N N 514 
TRP C     O      doub N N 515 
TRP C     OXT    sing N N 516 
TRP CB    CG     sing N N 517 
TRP CB    HB2    sing N N 518 
TRP CB    HB3    sing N N 519 
TRP CG    CD1    doub Y N 520 
TRP CG    CD2    sing Y N 521 
TRP CD1   NE1    sing Y N 522 
TRP CD1   HD1    sing N N 523 
TRP CD2   CE2    doub Y N 524 
TRP CD2   CE3    sing Y N 525 
TRP NE1   CE2    sing Y N 526 
TRP NE1   HE1    sing N N 527 
TRP CE2   CZ2    sing Y N 528 
TRP CE3   CZ3    doub Y N 529 
TRP CE3   HE3    sing N N 530 
TRP CZ2   CH2    doub Y N 531 
TRP CZ2   HZ2    sing N N 532 
TRP CZ3   CH2    sing Y N 533 
TRP CZ3   HZ3    sing N N 534 
TRP CH2   HH2    sing N N 535 
TRP OXT   HXT    sing N N 536 
TYR N     CA     sing N N 537 
TYR N     H      sing N N 538 
TYR N     H2     sing N N 539 
TYR CA    C      sing N N 540 
TYR CA    CB     sing N N 541 
TYR CA    HA     sing N N 542 
TYR C     O      doub N N 543 
TYR C     OXT    sing N N 544 
TYR CB    CG     sing N N 545 
TYR CB    HB2    sing N N 546 
TYR CB    HB3    sing N N 547 
TYR CG    CD1    doub Y N 548 
TYR CG    CD2    sing Y N 549 
TYR CD1   CE1    sing Y N 550 
TYR CD1   HD1    sing N N 551 
TYR CD2   CE2    doub Y N 552 
TYR CD2   HD2    sing N N 553 
TYR CE1   CZ     doub Y N 554 
TYR CE1   HE1    sing N N 555 
TYR CE2   CZ     sing Y N 556 
TYR CE2   HE2    sing N N 557 
TYR CZ    OH     sing N N 558 
TYR OH    HH     sing N N 559 
TYR OXT   HXT    sing N N 560 
VAL N     CA     sing N N 561 
VAL N     H      sing N N 562 
VAL N     H2     sing N N 563 
VAL CA    C      sing N N 564 
VAL CA    CB     sing N N 565 
VAL CA    HA     sing N N 566 
VAL C     O      doub N N 567 
VAL C     OXT    sing N N 568 
VAL CB    CG1    sing N N 569 
VAL CB    CG2    sing N N 570 
VAL CB    HB     sing N N 571 
VAL CG1   HG11   sing N N 572 
VAL CG1   HG12   sing N N 573 
VAL CG1   HG13   sing N N 574 
VAL CG2   HG21   sing N N 575 
VAL CG2   HG22   sing N N 576 
VAL CG2   HG23   sing N N 577 
VAL OXT   HXT    sing N N 578 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8XK7 'double helix'        
8XK7 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B DC 4  1_555 C OMG 13 1_555 0.091  -0.151 0.177  -10.260 -3.312  0.630  1  B_DC205:OMG112_C B 205 ? C 112 ? 19 1 
1 B DG 5  1_555 C DC  12 1_555 -0.156 -0.116 0.143  5.803   -8.133  -3.365 2  B_DG206:DC111_C  B 206 ? C 111 ? 19 1 
1 B DG 6  1_555 C DC  11 1_555 -0.064 -0.171 -0.017 -8.703  -27.919 -0.263 3  B_DG207:DC110_C  B 207 ? C 110 ? 19 1 
1 B DC 7  1_555 C DG  10 1_555 0.174  -0.084 -0.041 -11.950 6.132   -0.814 4  B_DC208:DG109_C  B 208 ? C 109 ? 19 1 
1 B DG 8  1_555 C DC  9  1_555 -0.339 -0.156 -0.347 -0.127  -0.438  -0.274 5  B_DG209:DC108_C  B 209 ? C 108 ? 19 1 
1 B DC 9  1_555 C DG  8  1_555 0.258  -0.093 0.145  2.889   -8.811  1.223  6  B_DC210:DG107_C  B 210 ? C 107 ? 19 1 
1 B DC 10 1_555 C DG  7  1_555 0.172  -0.121 0.222  -9.893  -12.737 1.772  7  B_DC211:DG106_C  B 211 ? C 106 ? 19 1 
1 B DG 11 1_555 C DC  6  1_555 -0.186 0.077  0.191  4.850   -9.101  -0.204 8  B_DG212:DC105_C  B 212 ? C 105 ? 19 1 
1 B DT 12 1_555 C DA  5  1_555 0.128  -0.056 -0.099 3.508   -15.679 -0.210 9  B_DT213:DA104_C  B 213 ? C 104 ? 20 1 
1 B DG 13 1_555 C DC  4  1_555 -0.665 0.014  0.436  7.615   -10.582 5.633  10 B_DG214:DC103_C  B 214 ? C 103 ? 19 1 
1 B DG 14 1_555 C DC  3  1_555 -0.152 -0.048 0.094  2.135   -11.983 1.825  11 B_DG215:DC102_C  B 215 ? C 102 ? 19 1 
1 B DT 15 1_555 C DA  2  1_555 0.138  -0.167 0.035  2.492   -13.945 -0.990 12 B_DT216:DA101_C  B 216 ? C 101 ? 20 1 
1 B DC 16 1_555 C DG  1  1_555 0.085  -0.072 -0.194 8.131   -15.766 3.699  13 B_DC217:DG100_C  B 217 ? C 100 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B DC 4  1_555 C OMG 13 1_555 B DG 5  1_555 C DC 12 1_555 0.598  -0.169 3.046 -0.534 8.999  23.454 -2.837 -1.521 2.776 21.162 
1.256  25.104 1  BB_DC205DG206:DC111OMG112_CC B 205 ? C 112 ? B 206 ? C 111 ? 
1 B DG 5  1_555 C DC  12 1_555 B DG 6  1_555 C DC 11 1_555 -0.168 -0.583 3.797 -4.381 9.196  35.602 -2.336 -0.410 3.538 14.673 
6.990  36.985 2  BB_DG206DG207:DC110DC111_CC  B 206 ? C 111 ? B 207 ? C 110 ? 
1 B DG 6  1_555 C DC  11 1_555 B DC 7  1_555 C DG 10 1_555 1.096  -0.435 3.431 5.747  7.106  40.732 -1.406 -0.896 3.428 10.057 
-8.133 41.702 3  BB_DG207DC208:DG109DC110_CC  B 207 ? C 110 ? B 208 ? C 109 ? 
1 B DC 7  1_555 C DG  10 1_555 B DG 8  1_555 C DC 9  1_555 -0.528 -0.696 3.198 1.826  8.207  23.658 -3.877 1.721  2.756 19.256 
-4.284 25.088 4  BB_DC208DG209:DC108DG109_CC  B 208 ? C 109 ? B 209 ? C 108 ? 
1 B DG 8  1_555 C DC  9  1_555 B DC 9  1_555 C DG 8  1_555 -0.866 -0.169 3.260 -3.887 -0.981 35.967 -0.133 0.841  3.335 -1.582 
6.271  36.182 5  BB_DG209DC210:DG107DC108_CC  B 209 ? C 108 ? B 210 ? C 107 ? 
1 B DC 9  1_555 C DG  8  1_555 B DC 10 1_555 C DG 7  1_555 0.813  -0.322 3.475 3.811  4.032  38.601 -1.003 -0.725 3.486 6.061  
-5.728 38.982 6  BB_DC210DC211:DG106DG107_CC  B 210 ? C 107 ? B 211 ? C 106 ? 
1 B DC 10 1_555 C DG  7  1_555 B DG 11 1_555 C DC 6  1_555 -0.321 0.322  3.022 1.243  9.187  29.118 -1.102 0.842  2.968 17.715 
-2.397 30.528 7  BB_DC211DG212:DC105DG106_CC  B 211 ? C 106 ? B 212 ? C 105 ? 
1 B DG 11 1_555 C DC  6  1_555 B DT 12 1_555 C DA 5  1_555 -0.106 -0.200 3.386 2.456  0.347  33.299 -0.408 0.606  3.368 0.604  
-4.278 33.389 8  BB_DG212DT213:DA104DC105_CC  B 212 ? C 105 ? B 213 ? C 104 ? 
1 B DT 12 1_555 C DA  5  1_555 B DG 13 1_555 C DC 4  1_555 0.513  0.980  3.233 -2.561 7.232  33.292 0.507  -1.286 3.319 12.418 
4.398  34.140 9  BB_DT213DG214:DC103DA104_CC  B 213 ? C 104 ? B 214 ? C 103 ? 
1 B DG 13 1_555 C DC  4  1_555 B DG 14 1_555 C DC 3  1_555 -0.396 -0.097 3.447 -1.344 5.882  37.232 -0.952 0.429  3.405 9.140  
2.089  37.701 10 BB_DG214DG215:DC102DC103_CC  B 214 ? C 103 ? B 215 ? C 102 ? 
1 B DG 14 1_555 C DC  3  1_555 B DT 15 1_555 C DA 2  1_555 -0.366 -0.574 3.275 0.630  3.926  31.558 -1.759 0.782  3.175 7.184  
-1.152 31.801 11 BB_DG215DT216:DA101DC102_CC  B 215 ? C 102 ? B 216 ? C 101 ? 
1 B DT 15 1_555 C DA  2  1_555 B DC 16 1_555 C DG 1  1_555 0.505  0.145  3.132 3.903  2.937  33.704 -0.205 -0.260 3.170 5.032  
-6.688 34.046 12 BB_DT216DC217:DG100DA101_CC  B 216 ? C 101 ? B 217 ? C 100 ? 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'structure of apo SFM4-3' 
# 
_atom_sites.entry_id                    8XK7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016231 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003900 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015237 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009578 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . GLU A 1 3   ? 10.447  99.729  -9.084  1.00 45.67 ? 296  GLU A N     1 
ATOM   2    C CA    . GLU A 1 3   ? 9.249   99.452  -9.921  1.00 45.55 ? 296  GLU A CA    1 
ATOM   3    C C     . GLU A 1 3   ? 8.393   100.715 -9.958  1.00 43.27 ? 296  GLU A C     1 
ATOM   4    O O     . GLU A 1 3   ? 8.088   101.213 -11.031 1.00 42.53 ? 296  GLU A O     1 
ATOM   5    C CB    . GLU A 1 3   ? 8.450   98.255  -9.398  1.00 48.52 ? 296  GLU A CB    1 
ATOM   6    C CG    . GLU A 1 3   ? 7.450   97.723  -10.413 1.00 51.39 ? 296  GLU A CG    1 
ATOM   7    C CD    . GLU A 1 3   ? 6.542   96.604  -9.933  1.00 53.88 ? 296  GLU A CD    1 
ATOM   8    O OE1   . GLU A 1 3   ? 5.878   95.967  -10.779 1.00 58.21 ? 296  GLU A OE1   1 
ATOM   9    O OE2   . GLU A 1 3   ? 6.496   96.373  -8.725  1.00 52.92 ? 296  GLU A OE2   1 
ATOM   10   N N     . ALA A 1 4   ? 8.023   101.225 -8.779  1.00 41.21 ? 297  ALA A N     1 
ATOM   11   C CA    . ALA A 1 4   ? 7.313   102.489 -8.675  1.00 38.43 ? 297  ALA A CA    1 
ATOM   12   C C     . ALA A 1 4   ? 7.936   103.308 -7.551  1.00 35.71 ? 297  ALA A C     1 
ATOM   13   O O     . ALA A 1 4   ? 8.295   102.773 -6.506  1.00 33.23 ? 297  ALA A O     1 
ATOM   14   C CB    . ALA A 1 4   ? 5.845   102.243 -8.443  1.00 39.93 ? 297  ALA A CB    1 
ATOM   15   N N     . PRO A 1 5   ? 8.139   104.630 -7.734  1.00 33.48 ? 298  PRO A N     1 
ATOM   16   C CA    . PRO A 1 5   ? 8.753   105.431 -6.686  1.00 32.20 ? 298  PRO A CA    1 
ATOM   17   C C     . PRO A 1 5   ? 7.842   105.522 -5.462  1.00 30.75 ? 298  PRO A C     1 
ATOM   18   O O     . PRO A 1 5   ? 6.616   105.511 -5.575  1.00 32.54 ? 298  PRO A O     1 
ATOM   19   C CB    . PRO A 1 5   ? 8.992   106.801 -7.348  1.00 31.85 ? 298  PRO A CB    1 
ATOM   20   C CG    . PRO A 1 5   ? 7.994   106.844 -8.480  1.00 33.14 ? 298  PRO A CG    1 
ATOM   21   C CD    . PRO A 1 5   ? 7.815   105.408 -8.937  1.00 32.23 ? 298  PRO A CD    1 
ATOM   22   N N     . TRP A 1 6   ? 8.473   105.601 -4.294  1.00 30.67 ? 299  TRP A N     1 
ATOM   23   C CA    . TRP A 1 6   ? 7.804   105.988 -3.062  1.00 32.41 ? 299  TRP A CA    1 
ATOM   24   C C     . TRP A 1 6   ? 7.193   107.379 -3.257  1.00 33.98 ? 299  TRP A C     1 
ATOM   25   O O     . TRP A 1 6   ? 7.764   108.174 -3.997  1.00 34.14 ? 299  TRP A O     1 
ATOM   26   C CB    . TRP A 1 6   ? 8.821   105.992 -1.919  1.00 32.74 ? 299  TRP A CB    1 
ATOM   27   C CG    . TRP A 1 6   ? 8.188   105.969 -0.564  1.00 33.97 ? 299  TRP A CG    1 
ATOM   28   C CD1   . TRP A 1 6   ? 8.047   107.008 0.309   1.00 34.24 ? 299  TRP A CD1   1 
ATOM   29   C CD2   . TRP A 1 6   ? 7.592   104.824 0.059   1.00 32.94 ? 299  TRP A CD2   1 
ATOM   30   N NE1   . TRP A 1 6   ? 7.369   106.592 1.422   1.00 33.87 ? 299  TRP A NE1   1 
ATOM   31   C CE2   . TRP A 1 6   ? 7.096   105.252 1.307   1.00 34.57 ? 299  TRP A CE2   1 
ATOM   32   C CE3   . TRP A 1 6   ? 7.439   103.483 -0.314  1.00 33.57 ? 299  TRP A CE3   1 
ATOM   33   C CZ2   . TRP A 1 6   ? 6.461   104.380 2.189   1.00 31.37 ? 299  TRP A CZ2   1 
ATOM   34   C CZ3   . TRP A 1 6   ? 6.795   102.626 0.553   1.00 33.74 ? 299  TRP A CZ3   1 
ATOM   35   C CH2   . TRP A 1 6   ? 6.317   103.072 1.786   1.00 33.75 ? 299  TRP A CH2   1 
ATOM   36   N N     . PRO A 1 7   ? 6.028   107.739 -2.659  1.00 31.97 ? 300  PRO A N     1 
ATOM   37   C CA    . PRO A 1 7   ? 5.242   106.881 -1.769  1.00 29.57 ? 300  PRO A CA    1 
ATOM   38   C C     . PRO A 1 7   ? 4.204   106.055 -2.520  1.00 28.18 ? 300  PRO A C     1 
ATOM   39   O O     . PRO A 1 7   ? 3.965   106.281 -3.704  1.00 27.60 ? 300  PRO A O     1 
ATOM   40   C CB    . PRO A 1 7   ? 4.583   107.921 -0.851  1.00 30.38 ? 300  PRO A CB    1 
ATOM   41   C CG    . PRO A 1 7   ? 4.267   109.069 -1.800  1.00 31.81 ? 300  PRO A CG    1 
ATOM   42   C CD    . PRO A 1 7   ? 5.388   109.052 -2.824  1.00 33.47 ? 300  PRO A CD    1 
ATOM   43   N N     . PRO A 1 8   ? 3.575   105.048 -1.874  1.00 27.97 ? 301  PRO A N     1 
ATOM   44   C CA    . PRO A 1 8   ? 2.551   104.237 -2.533  1.00 29.80 ? 301  PRO A CA    1 
ATOM   45   C C     . PRO A 1 8   ? 1.217   104.986 -2.600  1.00 31.72 ? 301  PRO A C     1 
ATOM   46   O O     . PRO A 1 8   ? 1.032   106.022 -1.957  1.00 31.54 ? 301  PRO A O     1 
ATOM   47   C CB    . PRO A 1 8   ? 2.487   102.995 -1.617  1.00 30.21 ? 301  PRO A CB    1 
ATOM   48   C CG    . PRO A 1 8   ? 2.751   103.561 -0.247  1.00 29.75 ? 301  PRO A CG    1 
ATOM   49   C CD    . PRO A 1 8   ? 3.801   104.633 -0.478  1.00 30.63 ? 301  PRO A CD    1 
ATOM   50   N N     . PRO A 1 9   ? 0.218   104.480 -3.352  1.00 36.84 ? 302  PRO A N     1 
ATOM   51   C CA    . PRO A 1 9   ? -1.142  105.010 -3.238  1.00 40.25 ? 302  PRO A CA    1 
ATOM   52   C C     . PRO A 1 9   ? -1.804  104.524 -1.948  1.00 42.02 ? 302  PRO A C     1 
ATOM   53   O O     . PRO A 1 9   ? -1.233  103.717 -1.207  1.00 37.18 ? 302  PRO A O     1 
ATOM   54   C CB    . PRO A 1 9   ? -1.816  104.475 -4.504  1.00 40.40 ? 302  PRO A CB    1 
ATOM   55   C CG    . PRO A 1 9   ? -1.098  103.171 -4.782  1.00 39.18 ? 302  PRO A CG    1 
ATOM   56   C CD    . PRO A 1 9   ? 0.327   103.388 -4.327  1.00 38.02 ? 302  PRO A CD    1 
ATOM   57   N N     . GLU A 1 10  ? -3.012  105.035 -1.686  1.00 39.50 ? 303  GLU A N     1 
ATOM   58   C CA    . GLU A 1 10  ? -3.764  104.669 -0.496  1.00 42.64 ? 303  GLU A CA    1 
ATOM   59   C C     . GLU A 1 10  ? -4.066  103.174 -0.485  1.00 38.40 ? 303  GLU A C     1 
ATOM   60   O O     . GLU A 1 10  ? -4.216  102.563 -1.539  1.00 37.03 ? 303  GLU A O     1 
ATOM   61   C CB    . GLU A 1 10  ? -5.091  105.427 -0.445  1.00 44.39 ? 303  GLU A CB    1 
ATOM   62   C CG    . GLU A 1 10  ? -4.909  106.921 -0.340  1.00 51.77 ? 303  GLU A CG    1 
ATOM   63   C CD    . GLU A 1 10  ? -6.103  107.633 0.264   1.00 56.88 ? 303  GLU A CD    1 
ATOM   64   O OE1   . GLU A 1 10  ? -7.228  107.370 -0.213  1.00 55.81 ? 303  GLU A OE1   1 
ATOM   65   O OE2   . GLU A 1 10  ? -5.896  108.436 1.206   1.00 58.54 ? 303  GLU A OE2   1 
ATOM   66   N N     . GLY A 1 11  ? -4.162  102.611 0.726   1.00 41.05 ? 304  GLY A N     1 
ATOM   67   C CA    . GLY A 1 11  ? -4.551  101.222 0.919   1.00 42.04 ? 304  GLY A CA    1 
ATOM   68   C C     . GLY A 1 11  ? -3.473  100.220 0.502   1.00 41.42 ? 304  GLY A C     1 
ATOM   69   O O     . GLY A 1 11  ? -3.781  99.057  0.239   1.00 45.43 ? 304  GLY A O     1 
ATOM   70   N N     . ALA A 1 12  ? -2.208  100.657 0.444   1.00 36.63 ? 305  ALA A N     1 
ATOM   71   C CA    . ALA A 1 12  ? -1.127  99.766  0.037   1.00 33.30 ? 305  ALA A CA    1 
ATOM   72   C C     . ALA A 1 12  ? -0.763  98.867  1.215   1.00 30.39 ? 305  ALA A C     1 
ATOM   73   O O     . ALA A 1 12  ? -0.956  99.243  2.361   1.00 29.83 ? 305  ALA A O     1 
ATOM   74   C CB    . ALA A 1 12  ? 0.066   100.574 -0.433  1.00 32.22 ? 305  ALA A CB    1 
ATOM   75   N N     . PHE A 1 13  ? -0.238  97.679  0.925   1.00 31.11 ? 306  PHE A N     1 
ATOM   76   C CA    . PHE A 1 13  ? 0.250   96.784  1.962   1.00 31.14 ? 306  PHE A CA    1 
ATOM   77   C C     . PHE A 1 13  ? 1.742   97.014  2.185   1.00 31.53 ? 306  PHE A C     1 
ATOM   78   O O     . PHE A 1 13  ? 2.506   97.163  1.233   1.00 33.04 ? 306  PHE A O     1 
ATOM   79   C CB    . PHE A 1 13  ? -0.032  95.329  1.596   1.00 31.52 ? 306  PHE A CB    1 
ATOM   80   C CG    . PHE A 1 13  ? -1.499  94.995  1.619   1.00 32.18 ? 306  PHE A CG    1 
ATOM   81   C CD1   . PHE A 1 13  ? -2.332  95.385  0.577   1.00 33.29 ? 306  PHE A CD1   1 
ATOM   82   C CD2   . PHE A 1 13  ? -2.060  94.353  2.720   1.00 33.88 ? 306  PHE A CD2   1 
ATOM   83   C CE1   . PHE A 1 13  ? -3.691  95.097  0.613   1.00 33.80 ? 306  PHE A CE1   1 
ATOM   84   C CE2   . PHE A 1 13  ? -3.421  94.083  2.759   1.00 35.40 ? 306  PHE A CE2   1 
ATOM   85   C CZ    . PHE A 1 13  ? -4.232  94.454  1.705   1.00 34.12 ? 306  PHE A CZ    1 
ATOM   86   N N     . VAL A 1 14  ? 2.149   97.012  3.455   1.00 27.67 ? 307  VAL A N     1 
ATOM   87   C CA    . VAL A 1 14  ? 3.518   97.304  3.817   1.00 29.23 ? 307  VAL A CA    1 
ATOM   88   C C     . VAL A 1 14  ? 4.308   95.994  3.898   1.00 29.18 ? 307  VAL A C     1 
ATOM   89   O O     . VAL A 1 14  ? 3.762   94.919  4.178   1.00 28.74 ? 307  VAL A O     1 
ATOM   90   C CB    . VAL A 1 14  ? 3.567   98.097  5.136   1.00 32.78 ? 307  VAL A CB    1 
ATOM   91   C CG1   . VAL A 1 14  ? 3.222   97.219  6.335   1.00 33.52 ? 307  VAL A CG1   1 
ATOM   92   C CG2   . VAL A 1 14  ? 4.918   98.764  5.334   1.00 32.98 ? 307  VAL A CG2   1 
ATOM   93   N N     . GLY A 1 15  ? 5.603   96.117  3.613   1.00 27.18 ? 308  GLY A N     1 
ATOM   94   C CA    . GLY A 1 15  ? 6.611   95.118  3.945   1.00 27.13 ? 308  GLY A CA    1 
ATOM   95   C C     . GLY A 1 15  ? 7.819   95.804  4.577   1.00 28.18 ? 308  GLY A C     1 
ATOM   96   O O     . GLY A 1 15  ? 8.122   96.952  4.251   1.00 29.25 ? 308  GLY A O     1 
ATOM   97   N N     . PHE A 1 16  ? 8.500   95.124  5.508   1.00 27.50 ? 309  PHE A N     1 
ATOM   98   C CA    . PHE A 1 16  ? 9.594   95.769  6.219   1.00 28.55 ? 309  PHE A CA    1 
ATOM   99   C C     . PHE A 1 16  ? 10.604  94.723  6.699   1.00 28.94 ? 309  PHE A C     1 
ATOM   100  O O     . PHE A 1 16  ? 10.274  93.540  6.852   1.00 26.45 ? 309  PHE A O     1 
ATOM   101  C CB    . PHE A 1 16  ? 9.031   96.627  7.358   1.00 29.81 ? 309  PHE A CB    1 
ATOM   102  C CG    . PHE A 1 16  ? 8.285   95.835  8.403   1.00 30.16 ? 309  PHE A CG    1 
ATOM   103  C CD1   . PHE A 1 16  ? 6.957   95.469  8.216   1.00 30.44 ? 309  PHE A CD1   1 
ATOM   104  C CD2   . PHE A 1 16  ? 8.933   95.411  9.551   1.00 29.42 ? 309  PHE A CD2   1 
ATOM   105  C CE1   . PHE A 1 16  ? 6.284   94.724  9.173   1.00 32.12 ? 309  PHE A CE1   1 
ATOM   106  C CE2   . PHE A 1 16  ? 8.251   94.675  10.512  1.00 32.65 ? 309  PHE A CE2   1 
ATOM   107  C CZ    . PHE A 1 16  ? 6.935   94.313  10.309  1.00 31.33 ? 309  PHE A CZ    1 
ATOM   108  N N     . VAL A 1 17  ? 11.846  95.181  6.902   1.00 29.25 ? 310  VAL A N     1 
ATOM   109  C CA    . VAL A 1 17  ? 12.915  94.333  7.411   1.00 31.28 ? 310  VAL A CA    1 
ATOM   110  C C     . VAL A 1 17  ? 13.509  95.036  8.627   1.00 34.77 ? 310  VAL A C     1 
ATOM   111  O O     . VAL A 1 17  ? 13.796  96.241  8.570   1.00 32.55 ? 310  VAL A O     1 
ATOM   112  C CB    . VAL A 1 17  ? 13.997  94.018  6.355   1.00 31.29 ? 310  VAL A CB    1 
ATOM   113  C CG1   . VAL A 1 17  ? 15.117  93.154  6.930   1.00 32.38 ? 310  VAL A CG1   1 
ATOM   114  C CG2   . VAL A 1 17  ? 13.421  93.328  5.128   1.00 32.86 ? 310  VAL A CG2   1 
ATOM   115  N N     . LEU A 1 18  ? 13.624  94.271  9.729   1.00 32.04 ? 311  LEU A N     1 
ATOM   116  C CA    . LEU A 1 18  ? 14.219  94.753  10.970  1.00 33.54 ? 311  LEU A CA    1 
ATOM   117  C C     . LEU A 1 18  ? 15.593  94.105  11.137  1.00 32.71 ? 311  LEU A C     1 
ATOM   118  O O     . LEU A 1 18  ? 15.822  93.012  10.631  1.00 31.37 ? 311  LEU A O     1 
ATOM   119  C CB    . LEU A 1 18  ? 13.315  94.373  12.151  1.00 33.06 ? 311  LEU A CB    1 
ATOM   120  C CG    . LEU A 1 18  ? 11.869  94.870  12.103  1.00 33.10 ? 311  LEU A CG    1 
ATOM   121  C CD1   . LEU A 1 18  ? 11.120  94.421  13.347  1.00 32.24 ? 311  LEU A CD1   1 
ATOM   122  C CD2   . LEU A 1 18  ? 11.803  96.389  11.953  1.00 32.01 ? 311  LEU A CD2   1 
ATOM   123  N N     . SER A 1 19  ? 16.480  94.767  11.883  1.00 33.99 ? 312  SER A N     1 
ATOM   124  C CA    . SER A 1 19  ? 17.806  94.234  12.176  1.00 35.02 ? 312  SER A CA    1 
ATOM   125  C C     . SER A 1 19  ? 17.711  93.075  13.164  1.00 33.03 ? 312  SER A C     1 
ATOM   126  O O     . SER A 1 19  ? 18.612  92.248  13.207  1.00 31.74 ? 312  SER A O     1 
ATOM   127  C CB    . SER A 1 19  ? 18.718  95.300  12.722  1.00 33.49 ? 312  SER A CB    1 
ATOM   128  O OG    . SER A 1 19  ? 18.150  95.876  13.894  1.00 33.60 ? 312  SER A OG    1 
ATOM   129  N N     . ARG A 1 20  ? 16.636  93.047  13.965  1.00 32.79 ? 313  ARG A N     1 
ATOM   130  C CA    . ARG A 1 20  ? 16.383  91.960  14.902  1.00 34.49 ? 313  ARG A CA    1 
ATOM   131  C C     . ARG A 1 20  ? 14.874  91.797  15.096  1.00 32.23 ? 313  ARG A C     1 
ATOM   132  O O     . ARG A 1 20  ? 14.099  92.675  14.726  1.00 29.65 ? 313  ARG A O     1 
ATOM   133  C CB    . ARG A 1 20  ? 17.104  92.217  16.228  1.00 34.26 ? 313  ARG A CB    1 
ATOM   134  C CG    . ARG A 1 20  ? 16.915  93.621  16.787  1.00 36.48 ? 313  ARG A CG    1 
ATOM   135  C CD    . ARG A 1 20  ? 17.840  93.905  17.959  1.00 39.79 ? 313  ARG A CD    1 
ATOM   136  N NE    . ARG A 1 20  ? 17.660  92.940  19.031  1.00 40.89 ? 313  ARG A NE    1 
ATOM   137  C CZ    . ARG A 1 20  ? 18.277  92.980  20.207  1.00 45.62 ? 313  ARG A CZ    1 
ATOM   138  N NH1   . ARG A 1 20  ? 19.088  93.981  20.506  1.00 44.76 ? 313  ARG A NH1   1 
ATOM   139  N NH2   . ARG A 1 20  ? 18.058  92.016  21.088  1.00 44.44 ? 313  ARG A NH2   1 
ATOM   140  N N     . LYS A 1 21  ? 14.461  90.657  15.661  1.00 32.24 ? 314  LYS A N     1 
ATOM   141  C CA    . LYS A 1 21  ? 13.039  90.325  15.734  1.00 33.62 ? 314  LYS A CA    1 
ATOM   142  C C     . LYS A 1 21  ? 12.280  91.267  16.684  1.00 33.29 ? 314  LYS A C     1 
ATOM   143  O O     . LYS A 1 21  ? 11.093  91.523  16.469  1.00 36.01 ? 314  LYS A O     1 
ATOM   144  C CB    . LYS A 1 21  ? 12.850  88.862  16.141  1.00 33.20 ? 314  LYS A CB    1 
ATOM   145  C CG    . LYS A 1 21  ? 13.488  88.520  17.479  1.00 37.43 ? 314  LYS A CG    1 
ATOM   146  C CD    . LYS A 1 21  ? 12.960  87.297  18.150  1.00 41.30 ? 314  LYS A CD    1 
ATOM   147  C CE    . LYS A 1 21  ? 13.969  86.180  18.216  1.00 44.20 ? 314  LYS A CE    1 
ATOM   148  N NZ    . LYS A 1 21  ? 13.595  85.216  19.276  1.00 44.27 ? 314  LYS A NZ    1 
ATOM   149  N N     . GLU A 1 22  ? 12.957  91.800  17.711  1.00 32.92 ? 315  GLU A N     1 
ATOM   150  C CA    . GLU A 1 22  ? 12.311  92.595  18.747  1.00 32.61 ? 315  GLU A CA    1 
ATOM   151  C C     . GLU A 1 22  ? 12.147  94.026  18.250  1.00 31.87 ? 315  GLU A C     1 
ATOM   152  O O     . GLU A 1 22  ? 13.125  94.766  18.160  1.00 32.32 ? 315  GLU A O     1 
ATOM   153  C CB    . GLU A 1 22  ? 13.117  92.657  20.052  1.00 33.72 ? 315  GLU A CB    1 
ATOM   154  C CG    . GLU A 1 22  ? 13.499  91.317  20.645  1.00 38.36 ? 315  GLU A CG    1 
ATOM   155  C CD    . GLU A 1 22  ? 14.836  90.733  20.196  1.00 38.24 ? 315  GLU A CD    1 
ATOM   156  O OE1   . GLU A 1 22  ? 15.344  91.121  19.122  1.00 37.19 ? 315  GLU A OE1   1 
ATOM   157  O OE2   . GLU A 1 22  ? 15.382  89.910  20.941  1.00 43.91 ? 315  GLU A OE2   1 
ATOM   158  N N     . PRO A 1 23  ? 10.918  94.488  17.943  1.00 32.88 ? 316  PRO A N     1 
ATOM   159  C CA    . PRO A 1 23  ? 10.746  95.808  17.339  1.00 33.57 ? 316  PRO A CA    1 
ATOM   160  C C     . PRO A 1 23  ? 11.225  96.982  18.189  1.00 33.63 ? 316  PRO A C     1 
ATOM   161  O O     . PRO A 1 23  ? 11.626  98.002  17.634  1.00 33.12 ? 316  PRO A O     1 
ATOM   162  C CB    . PRO A 1 23  ? 9.236   95.916  17.055  1.00 34.54 ? 316  PRO A CB    1 
ATOM   163  C CG    . PRO A 1 23  ? 8.586   94.800  17.840  1.00 35.72 ? 316  PRO A CG    1 
ATOM   164  C CD    . PRO A 1 23  ? 9.650   93.750  18.068  1.00 35.41 ? 316  PRO A CD    1 
ATOM   165  N N     . MET A 1 24  ? 11.193  96.861  19.526  1.00 31.51 ? 317  MET A N     1 
ATOM   166  C CA    . MET A 1 24  ? 11.605  97.982  20.352  1.00 30.93 ? 317  MET A CA    1 
ATOM   167  C C     . MET A 1 24  ? 13.125  98.154  20.290  1.00 29.69 ? 317  MET A C     1 
ATOM   168  O O     . MET A 1 24  ? 13.622  99.219  20.621  1.00 29.74 ? 317  MET A O     1 
ATOM   169  C CB    . MET A 1 24  ? 11.159  97.853  21.813  1.00 30.37 ? 317  MET A CB    1 
ATOM   170  C CG    . MET A 1 24  ? 9.715   98.251  22.058  1.00 30.39 ? 317  MET A CG    1 
ATOM   171  S SD    . MET A 1 24  ? 9.263   99.949  21.614  1.00 33.13 ? 317  MET A SD    1 
ATOM   172  C CE    . MET A 1 24  ? 10.332  100.876 22.717  1.00 33.25 ? 317  MET A CE    1 
ATOM   173  N N     . TRP A 1 25  ? 13.851  97.116  19.865  1.00 31.57 ? 318  TRP A N     1 
ATOM   174  C CA    . TRP A 1 25  ? 15.301  97.126  19.853  1.00 33.00 ? 318  TRP A CA    1 
ATOM   175  C C     . TRP A 1 25  ? 15.851  97.229  18.431  1.00 34.44 ? 318  TRP A C     1 
ATOM   176  O O     . TRP A 1 25  ? 17.057  97.402  18.256  1.00 35.26 ? 318  TRP A O     1 
ATOM   177  C CB    . TRP A 1 25  ? 15.828  95.876  20.570  1.00 34.57 ? 318  TRP A CB    1 
ATOM   178  C CG    . TRP A 1 25  ? 15.647  95.965  22.055  1.00 37.32 ? 318  TRP A CG    1 
ATOM   179  C CD1   . TRP A 1 25  ? 14.640  95.419  22.798  1.00 37.82 ? 318  TRP A CD1   1 
ATOM   180  C CD2   . TRP A 1 25  ? 16.484  96.676  22.982  1.00 37.00 ? 318  TRP A CD2   1 
ATOM   181  N NE1   . TRP A 1 25  ? 14.782  95.758  24.117  1.00 37.67 ? 318  TRP A NE1   1 
ATOM   182  C CE2   . TRP A 1 25  ? 15.914  96.512  24.265  1.00 38.49 ? 318  TRP A CE2   1 
ATOM   183  C CE3   . TRP A 1 25  ? 17.657  97.432  22.857  1.00 40.05 ? 318  TRP A CE3   1 
ATOM   184  C CZ2   . TRP A 1 25  ? 16.489  97.059  25.411  1.00 36.04 ? 318  TRP A CZ2   1 
ATOM   185  C CZ3   . TRP A 1 25  ? 18.216  97.982  23.992  1.00 39.22 ? 318  TRP A CZ3   1 
ATOM   186  C CH2   . TRP A 1 25  ? 17.637  97.799  25.248  1.00 35.74 ? 318  TRP A CH2   1 
ATOM   187  N N     . ALA A 1 26  ? 14.983  97.138  17.418  1.00 32.01 ? 319  ALA A N     1 
ATOM   188  C CA    . ALA A 1 26  ? 15.438  96.868  16.067  1.00 32.42 ? 319  ALA A CA    1 
ATOM   189  C C     . ALA A 1 26  ? 15.669  98.170  15.312  1.00 32.79 ? 319  ALA A C     1 
ATOM   190  O O     . ALA A 1 26  ? 15.011  99.182  15.558  1.00 33.81 ? 319  ALA A O     1 
ATOM   191  C CB    . ALA A 1 26  ? 14.446  95.992  15.335  1.00 30.99 ? 319  ALA A CB    1 
ATOM   192  N N     . ASP A 1 27  ? 16.603  98.104  14.366  1.00 34.11 ? 320  ASP A N     1 
ATOM   193  C CA    . ASP A 1 27  ? 16.745  99.141  13.363  1.00 37.36 ? 320  ASP A CA    1 
ATOM   194  C C     . ASP A 1 27  ? 15.863  98.753  12.175  1.00 35.35 ? 320  ASP A C     1 
ATOM   195  O O     . ASP A 1 27  ? 15.863  97.597  11.756  1.00 33.09 ? 320  ASP A O     1 
ATOM   196  C CB    . ASP A 1 27  ? 18.229  99.345  13.032  1.00 41.87 ? 320  ASP A CB    1 
ATOM   197  C CG    . ASP A 1 27  ? 18.537  100.586 12.204  1.00 47.12 ? 320  ASP A CG    1 
ATOM   198  O OD1   . ASP A 1 27  ? 17.842  101.630 12.378  1.00 46.04 ? 320  ASP A OD1   1 
ATOM   199  O OD2   . ASP A 1 27  ? 19.495  100.514 11.406  1.00 53.32 ? 320  ASP A OD2   1 
ATOM   200  N N     . LEU A 1 28  ? 15.078  99.717  11.677  1.00 31.30 ? 321  LEU A N     1 
ATOM   201  C CA    . LEU A 1 28  ? 14.296  99.539  10.465  1.00 33.25 ? 321  LEU A CA    1 
ATOM   202  C C     . LEU A 1 28  ? 15.235  99.658  9.265   1.00 33.97 ? 321  LEU A C     1 
ATOM   203  O O     . LEU A 1 28  ? 15.697  100.754 8.953   1.00 32.68 ? 321  LEU A O     1 
ATOM   204  C CB    . LEU A 1 28  ? 13.202  100.614 10.411  1.00 31.30 ? 321  LEU A CB    1 
ATOM   205  C CG    . LEU A 1 28  ? 12.263  100.563 9.212   1.00 31.41 ? 321  LEU A CG    1 
ATOM   206  C CD1   . LEU A 1 28  ? 11.545  99.222  9.124   1.00 31.20 ? 321  LEU A CD1   1 
ATOM   207  C CD2   . LEU A 1 28  ? 11.247  101.692 9.279   1.00 32.52 ? 321  LEU A CD2   1 
ATOM   208  N N     . LEU A 1 29  ? 15.512  98.524  8.616   1.00 32.39 ? 322  LEU A N     1 
ATOM   209  C CA    . LEU A 1 29  ? 16.506  98.470  7.554   1.00 34.81 ? 322  LEU A CA    1 
ATOM   210  C C     . LEU A 1 29  ? 15.876  98.826  6.210   1.00 34.73 ? 322  LEU A C     1 
ATOM   211  O O     . LEU A 1 29  ? 16.520  99.475  5.394   1.00 36.30 ? 322  LEU A O     1 
ATOM   212  C CB    . LEU A 1 29  ? 17.114  97.067  7.491   1.00 34.85 ? 322  LEU A CB    1 
ATOM   213  C CG    . LEU A 1 29  ? 17.813  96.583  8.759   1.00 35.12 ? 322  LEU A CG    1 
ATOM   214  C CD1   . LEU A 1 29  ? 18.398  95.203  8.529   1.00 37.35 ? 322  LEU A CD1   1 
ATOM   215  C CD2   . LEU A 1 29  ? 18.895  97.556  9.197   1.00 36.28 ? 322  LEU A CD2   1 
ATOM   216  N N     . ALA A 1 30  ? 14.650  98.338  5.967   1.00 31.71 ? 323  ALA A N     1 
ATOM   217  C CA    . ALA A 1 30  ? 13.990  98.494  4.685   1.00 31.55 ? 323  ALA A CA    1 
ATOM   218  C C     . ALA A 1 30  ? 12.479  98.596  4.902   1.00 33.85 ? 323  ALA A C     1 
ATOM   219  O O     . ALA A 1 30  ? 11.922  97.917  5.768   1.00 31.21 ? 323  ALA A O     1 
ATOM   220  C CB    . ALA A 1 30  ? 14.340  97.342  3.776   1.00 31.88 ? 323  ALA A CB    1 
ATOM   221  N N     . LEU A 1 31  ? 11.853  99.481  4.117   1.00 31.99 ? 324  LEU A N     1 
ATOM   222  C CA    . LEU A 1 31  ? 10.413  99.660  4.087   1.00 32.93 ? 324  LEU A CA    1 
ATOM   223  C C     . LEU A 1 31  ? 9.928   99.685  2.633   1.00 33.07 ? 324  LEU A C     1 
ATOM   224  O O     . LEU A 1 31  ? 10.551  100.284 1.752   1.00 30.80 ? 324  LEU A O     1 
ATOM   225  C CB    . LEU A 1 31  ? 10.049  100.960 4.807   1.00 31.72 ? 324  LEU A CB    1 
ATOM   226  C CG    . LEU A 1 31  ? 8.552   101.250 4.862   1.00 31.96 ? 324  LEU A CG    1 
ATOM   227  C CD1   . LEU A 1 31  ? 7.846   100.244 5.768   1.00 32.79 ? 324  LEU A CD1   1 
ATOM   228  C CD2   . LEU A 1 31  ? 8.291   102.674 5.321   1.00 33.73 ? 324  LEU A CD2   1 
ATOM   229  N N     . ALA A 1 32  ? 8.788   99.036  2.395   1.00 32.03 ? 325  ALA A N     1 
ATOM   230  C CA    . ALA A 1 32  ? 8.199   98.968  1.070   1.00 32.35 ? 325  ALA A CA    1 
ATOM   231  C C     . ALA A 1 32  ? 6.679   98.874  1.201   1.00 33.21 ? 325  ALA A C     1 
ATOM   232  O O     . ALA A 1 32  ? 6.167   98.615  2.299   1.00 30.66 ? 325  ALA A O     1 
ATOM   233  C CB    . ALA A 1 32  ? 8.785   97.802  0.318   1.00 31.78 ? 325  ALA A CB    1 
ATOM   234  N N     . ALA A 1 33  ? 5.979   99.104  0.080   1.00 31.53 ? 326  ALA A N     1 
ATOM   235  C CA    . ALA A 1 33  ? 4.523   98.997  0.021   1.00 31.60 ? 326  ALA A CA    1 
ATOM   236  C C     . ALA A 1 33  ? 4.096   98.498  -1.352  1.00 32.52 ? 326  ALA A C     1 
ATOM   237  O O     . ALA A 1 33  ? 4.704   98.866  -2.355  1.00 35.45 ? 326  ALA A O     1 
ATOM   238  C CB    . ALA A 1 33  ? 3.866   100.313 0.346   1.00 31.27 ? 326  ALA A CB    1 
ATOM   239  N N     . ALA A 1 34  ? 3.056   97.650  -1.376  1.00 31.79 ? 327  ALA A N     1 
ATOM   240  C CA    . ALA A 1 34  ? 2.523   97.089  -2.608  1.00 32.23 ? 327  ALA A CA    1 
ATOM   241  C C     . ALA A 1 34  ? 1.044   97.458  -2.752  1.00 33.83 ? 327  ALA A C     1 
ATOM   242  O O     . ALA A 1 34  ? 0.270   97.385  -1.794  1.00 33.01 ? 327  ALA A O     1 
ATOM   243  C CB    . ALA A 1 34  ? 2.726   95.588  -2.628  1.00 30.73 ? 327  ALA A CB    1 
ATOM   244  N N     . ARG A 1 35  ? 0.663   97.856  -3.973  1.00 35.18 ? 328  ARG A N     1 
ATOM   245  C CA    . ARG A 1 35  ? -0.732  98.022  -4.356  1.00 38.94 ? 328  ARG A CA    1 
ATOM   246  C C     . ARG A 1 35  ? -0.870  97.545  -5.804  1.00 37.69 ? 328  ARG A C     1 
ATOM   247  O O     . ARG A 1 35  ? -0.154  98.008  -6.693  1.00 34.75 ? 328  ARG A O     1 
ATOM   248  C CB    . ARG A 1 35  ? -1.155  99.481  -4.151  1.00 44.13 ? 328  ARG A CB    1 
ATOM   249  C CG    . ARG A 1 35  ? -2.586  99.677  -3.673  1.00 52.31 ? 328  ARG A CG    1 
ATOM   250  C CD    . ARG A 1 35  ? -3.650  99.094  -4.579  1.00 59.38 ? 328  ARG A CD    1 
ATOM   251  N NE    . ARG A 1 35  ? -5.002  99.419  -4.123  1.00 68.89 ? 328  ARG A NE    1 
ATOM   252  C CZ    . ARG A 1 35  ? -5.612  98.889  -3.059  1.00 76.95 ? 328  ARG A CZ    1 
ATOM   253  N NH1   . ARG A 1 35  ? -5.006  97.986  -2.305  1.00 78.64 ? 328  ARG A NH1   1 
ATOM   254  N NH2   . ARG A 1 35  ? -6.843  99.269  -2.754  1.00 78.61 ? 328  ARG A NH2   1 
ATOM   255  N N     . GLY A 1 36  ? -1.750  96.567  -6.030  1.00 36.11 ? 329  GLY A N     1 
ATOM   256  C CA    . GLY A 1 36  ? -1.958  96.022  -7.360  1.00 38.96 ? 329  GLY A CA    1 
ATOM   257  C C     . GLY A 1 36  ? -0.732  95.283  -7.887  1.00 39.97 ? 329  GLY A C     1 
ATOM   258  O O     . GLY A 1 36  ? -0.486  95.246  -9.089  1.00 41.92 ? 329  GLY A O     1 
ATOM   259  N N     . GLY A 1 37  ? 0.041   94.674  -6.987  1.00 38.91 ? 330  GLY A N     1 
ATOM   260  C CA    . GLY A 1 37  ? 1.222   93.934  -7.401  1.00 38.94 ? 330  GLY A CA    1 
ATOM   261  C C     . GLY A 1 37  ? 2.404   94.847  -7.728  1.00 37.31 ? 330  GLY A C     1 
ATOM   262  O O     . GLY A 1 37  ? 3.482   94.346  -8.022  1.00 38.79 ? 330  GLY A O     1 
ATOM   263  N N     . ARG A 1 38  ? 2.205   96.168  -7.644  1.00 35.85 ? 331  ARG A N     1 
ATOM   264  C CA    . ARG A 1 38  ? 3.257   97.141  -7.907  1.00 39.89 ? 331  ARG A CA    1 
ATOM   265  C C     . ARG A 1 38  ? 3.919   97.523  -6.584  1.00 35.85 ? 331  ARG A C     1 
ATOM   266  O O     . ARG A 1 38  ? 3.234   97.967  -5.669  1.00 32.92 ? 331  ARG A O     1 
ATOM   267  C CB    . ARG A 1 38  ? 2.702   98.400  -8.594  1.00 41.80 ? 331  ARG A CB    1 
ATOM   268  C CG    . ARG A 1 38  ? 1.988   98.151  -9.919  1.00 47.79 ? 331  ARG A CG    1 
ATOM   269  C CD    . ARG A 1 38  ? 2.815   97.394  -10.954 1.00 50.13 ? 331  ARG A CD    1 
ATOM   270  N NE    . ARG A 1 38  ? 2.195   97.314  -12.274 1.00 52.43 ? 331  ARG A NE    1 
ATOM   271  C CZ    . ARG A 1 38  ? 2.435   96.355  -13.166 1.00 55.88 ? 331  ARG A CZ    1 
ATOM   272  N NH1   . ARG A 1 38  ? 1.802   96.349  -14.326 1.00 56.77 ? 331  ARG A NH1   1 
ATOM   273  N NH2   . ARG A 1 38  ? 3.290   95.384  -12.889 1.00 57.06 ? 331  ARG A NH2   1 
ATOM   274  N N     . VAL A 1 39  ? 5.245   97.369  -6.511  1.00 32.66 ? 332  VAL A N     1 
ATOM   275  C CA    . VAL A 1 39  ? 5.996   97.577  -5.286  1.00 35.33 ? 332  VAL A CA    1 
ATOM   276  C C     . VAL A 1 39  ? 6.670   98.948  -5.319  1.00 31.96 ? 332  VAL A C     1 
ATOM   277  O O     . VAL A 1 39  ? 7.316   99.304  -6.304  1.00 34.37 ? 332  VAL A O     1 
ATOM   278  C CB    . VAL A 1 39  ? 7.039   96.461  -5.081  1.00 34.92 ? 332  VAL A CB    1 
ATOM   279  C CG1   . VAL A 1 39  ? 7.874   96.697  -3.841  1.00 36.43 ? 332  VAL A CG1   1 
ATOM   280  C CG2   . VAL A 1 39  ? 6.402   95.085  -5.038  1.00 38.03 ? 332  VAL A CG2   1 
ATOM   281  N N     . HIS A 1 40  ? 6.520   99.692  -4.221  1.00 30.22 ? 333  HIS A N     1 
ATOM   282  C CA    . HIS A 1 40  ? 7.227   100.946 -3.988  1.00 31.80 ? 333  HIS A CA    1 
ATOM   283  C C     . HIS A 1 40  ? 8.206   100.768 -2.830  1.00 30.22 ? 333  HIS A C     1 
ATOM   284  O O     . HIS A 1 40  ? 7.796   100.432 -1.724  1.00 30.12 ? 333  HIS A O     1 
ATOM   285  C CB    . HIS A 1 40  ? 6.248   102.075 -3.630  1.00 32.21 ? 333  HIS A CB    1 
ATOM   286  C CG    . HIS A 1 40  ? 5.084   102.257 -4.556  1.00 34.37 ? 333  HIS A CG    1 
ATOM   287  N ND1   . HIS A 1 40  ? 4.093   101.322 -4.743  1.00 35.10 ? 333  HIS A ND1   1 
ATOM   288  C CD2   . HIS A 1 40  ? 4.770   103.332 -5.337  1.00 33.44 ? 333  HIS A CD2   1 
ATOM   289  C CE1   . HIS A 1 40  ? 3.209   101.797 -5.619  1.00 33.13 ? 333  HIS A CE1   1 
ATOM   290  N NE2   . HIS A 1 40  ? 3.603   103.046 -5.990  1.00 34.51 ? 333  HIS A NE2   1 
ATOM   291  N N     . ARG A 1 41  ? 9.490   101.046 -3.056  1.00 31.29 ? 334  ARG A N     1 
ATOM   292  C CA    . ARG A 1 41  ? 10.498  100.859 -2.028  1.00 30.67 ? 334  ARG A CA    1 
ATOM   293  C C     . ARG A 1 41  ? 10.916  102.225 -1.502  1.00 32.06 ? 334  ARG A C     1 
ATOM   294  O O     . ARG A 1 41  ? 11.128  103.142 -2.285  1.00 30.96 ? 334  ARG A O     1 
ATOM   295  C CB    . ARG A 1 41  ? 11.665  100.049 -2.600  1.00 30.62 ? 334  ARG A CB    1 
ATOM   296  C CG    . ARG A 1 41  ? 11.271  98.641  -3.010  1.00 33.16 ? 334  ARG A CG    1 
ATOM   297  C CD    . ARG A 1 41  ? 12.445  97.928  -3.655  1.00 35.67 ? 334  ARG A CD    1 
ATOM   298  N NE    . ARG A 1 41  ? 12.233  96.494  -3.702  1.00 35.90 ? 334  ARG A NE    1 
ATOM   299  C CZ    . ARG A 1 41  ? 11.492  95.865  -4.608  1.00 38.15 ? 334  ARG A CZ    1 
ATOM   300  N NH1   . ARG A 1 41  ? 11.117  96.495  -5.707  1.00 35.07 ? 334  ARG A NH1   1 
ATOM   301  N NH2   . ARG A 1 41  ? 11.155  94.599  -4.427  1.00 34.98 ? 334  ARG A NH2   1 
ATOM   302  N N     . ALA A 1 42  ? 11.020  102.357 -0.172  1.00 32.03 ? 335  ALA A N     1 
ATOM   303  C CA    . ALA A 1 42  ? 11.340  103.633 0.443   1.00 33.84 ? 335  ALA A CA    1 
ATOM   304  C C     . ALA A 1 42  ? 12.848  103.877 0.358   1.00 37.99 ? 335  ALA A C     1 
ATOM   305  O O     . ALA A 1 42  ? 13.634  103.031 0.771   1.00 36.98 ? 335  ALA A O     1 
ATOM   306  C CB    . ALA A 1 42  ? 10.873  103.663 1.875   1.00 34.60 ? 335  ALA A CB    1 
ATOM   307  N N     . PRO A 1 43  ? 13.299  105.060 -0.116  1.00 38.37 ? 336  PRO A N     1 
ATOM   308  C CA    . PRO A 1 43  ? 14.726  105.391 -0.108  1.00 40.64 ? 336  PRO A CA    1 
ATOM   309  C C     . PRO A 1 43  ? 15.298  105.494 1.310   1.00 40.52 ? 336  PRO A C     1 
ATOM   310  O O     . PRO A 1 43  ? 16.419  105.058 1.545   1.00 44.01 ? 336  PRO A O     1 
ATOM   311  C CB    . PRO A 1 43  ? 14.850  106.742 -0.848  1.00 39.12 ? 336  PRO A CB    1 
ATOM   312  C CG    . PRO A 1 43  ? 13.424  107.190 -1.181  1.00 40.01 ? 336  PRO A CG    1 
ATOM   313  C CD    . PRO A 1 43  ? 12.460  106.172 -0.596  1.00 39.43 ? 336  PRO A CD    1 
ATOM   314  N N     . GLU A 1 44  ? 14.540  106.095 2.243   1.00 39.91 ? 337  GLU A N     1 
ATOM   315  C CA    . GLU A 1 44  ? 14.953  106.192 3.637   1.00 40.31 ? 337  GLU A CA    1 
ATOM   316  C C     . GLU A 1 44  ? 13.788  105.753 4.526   1.00 35.99 ? 337  GLU A C     1 
ATOM   317  O O     . GLU A 1 44  ? 12.800  106.474 4.662   1.00 34.77 ? 337  GLU A O     1 
ATOM   318  C CB    . GLU A 1 44  ? 15.431  107.605 3.997   1.00 41.81 ? 337  GLU A CB    1 
ATOM   319  C CG    . GLU A 1 44  ? 16.297  107.637 5.248   1.00 43.81 ? 337  GLU A CG    1 
ATOM   320  C CD    . GLU A 1 44  ? 15.557  107.459 6.570   1.00 48.93 ? 337  GLU A CD    1 
ATOM   321  O OE1   . GLU A 1 44  ? 15.802  106.437 7.270   1.00 42.97 ? 337  GLU A OE1   1 
ATOM   322  O OE2   . GLU A 1 44  ? 14.739  108.345 6.911   1.00 49.82 ? 337  GLU A OE2   1 
ATOM   323  N N     . PRO A 1 45  ? 13.873  104.552 5.147   1.00 34.60 ? 338  PRO A N     1 
ATOM   324  C CA    . PRO A 1 45  ? 12.732  103.937 5.827   1.00 34.71 ? 338  PRO A CA    1 
ATOM   325  C C     . PRO A 1 45  ? 12.043  104.748 6.921   1.00 31.82 ? 338  PRO A C     1 
ATOM   326  O O     . PRO A 1 45  ? 10.814  104.772 6.960   1.00 34.68 ? 338  PRO A O     1 
ATOM   327  C CB    . PRO A 1 45  ? 13.316  102.668 6.463   1.00 36.51 ? 338  PRO A CB    1 
ATOM   328  C CG    . PRO A 1 45  ? 14.530  102.346 5.626   1.00 39.27 ? 338  PRO A CG    1 
ATOM   329  C CD    . PRO A 1 45  ? 15.062  103.686 5.158   1.00 36.82 ? 338  PRO A CD    1 
ATOM   330  N N     . TYR A 1 46  ? 12.814  105.402 7.797   1.00 32.24 ? 339  TYR A N     1 
ATOM   331  C CA    . TYR A 1 46  ? 12.251  106.090 8.959   1.00 34.49 ? 339  TYR A CA    1 
ATOM   332  C C     . TYR A 1 46  ? 11.380  107.274 8.527   1.00 35.81 ? 339  TYR A C     1 
ATOM   333  O O     . TYR A 1 46  ? 10.247  107.426 8.965   1.00 35.37 ? 339  TYR A O     1 
ATOM   334  C CB    . TYR A 1 46  ? 13.359  106.535 9.922   1.00 34.43 ? 339  TYR A CB    1 
ATOM   335  C CG    . TYR A 1 46  ? 13.944  105.425 10.761  1.00 35.22 ? 339  TYR A CG    1 
ATOM   336  C CD1   . TYR A 1 46  ? 13.239  104.907 11.839  1.00 35.05 ? 339  TYR A CD1   1 
ATOM   337  C CD2   . TYR A 1 46  ? 15.171  104.859 10.459  1.00 34.69 ? 339  TYR A CD2   1 
ATOM   338  C CE1   . TYR A 1 46  ? 13.746  103.875 12.607  1.00 34.72 ? 339  TYR A CE1   1 
ATOM   339  C CE2   . TYR A 1 46  ? 15.691  103.818 11.213  1.00 36.79 ? 339  TYR A CE2   1 
ATOM   340  C CZ    . TYR A 1 46  ? 14.971  103.323 12.290  1.00 35.99 ? 339  TYR A CZ    1 
ATOM   341  O OH    . TYR A 1 46  ? 15.434  102.293 13.063  1.00 35.37 ? 339  TYR A OH    1 
ATOM   342  N N     . LYS A 1 47  ? 11.908  108.108 7.634   1.00 39.36 ? 340  LYS A N     1 
ATOM   343  C CA    . LYS A 1 47  ? 11.159  109.226 7.074   1.00 41.24 ? 340  LYS A CA    1 
ATOM   344  C C     . LYS A 1 47  ? 9.909   108.723 6.341   1.00 36.50 ? 340  LYS A C     1 
ATOM   345  O O     . LYS A 1 47  ? 8.865   109.364 6.383   1.00 36.81 ? 340  LYS A O     1 
ATOM   346  C CB    . LYS A 1 47  ? 12.096  109.994 6.135   1.00 46.13 ? 340  LYS A CB    1 
ATOM   347  C CG    . LYS A 1 47  ? 11.737  111.444 5.853   1.00 53.11 ? 340  LYS A CG    1 
ATOM   348  C CD    . LYS A 1 47  ? 12.787  112.116 4.983   1.00 57.14 ? 340  LYS A CD    1 
ATOM   349  C CE    . LYS A 1 47  ? 13.096  113.531 5.422   1.00 62.16 ? 340  LYS A CE    1 
ATOM   350  N NZ    . LYS A 1 47  ? 11.905  114.404 5.330   1.00 63.46 ? 340  LYS A NZ    1 
ATOM   351  N N     . ALA A 1 48  ? 10.024  107.562 5.677   1.00 38.16 ? 341  ALA A N     1 
ATOM   352  C CA    . ALA A 1 48  ? 8.959   106.990 4.860   1.00 35.62 ? 341  ALA A CA    1 
ATOM   353  C C     . ALA A 1 48  ? 7.799   106.446 5.702   1.00 37.94 ? 341  ALA A C     1 
ATOM   354  O O     . ALA A 1 48  ? 6.697   106.262 5.181   1.00 39.09 ? 341  ALA A O     1 
ATOM   355  C CB    . ALA A 1 48  ? 9.536   105.918 3.969   1.00 34.22 ? 341  ALA A CB    1 
ATOM   356  N N     . LEU A 1 49  ? 8.036   106.195 6.996   1.00 36.20 ? 342  LEU A N     1 
ATOM   357  C CA    . LEU A 1 49  ? 6.981   105.784 7.910   1.00 38.47 ? 342  LEU A CA    1 
ATOM   358  C C     . LEU A 1 49  ? 5.857   106.820 7.947   1.00 40.93 ? 342  LEU A C     1 
ATOM   359  O O     . LEU A 1 49  ? 4.693   106.437 8.051   1.00 40.47 ? 342  LEU A O     1 
ATOM   360  C CB    . LEU A 1 49  ? 7.577   105.554 9.306   1.00 36.51 ? 342  LEU A CB    1 
ATOM   361  C CG    . LEU A 1 49  ? 8.386   104.271 9.474   1.00 38.16 ? 342  LEU A CG    1 
ATOM   362  C CD1   . LEU A 1 49  ? 9.041   104.235 10.844  1.00 40.47 ? 342  LEU A CD1   1 
ATOM   363  C CD2   . LEU A 1 49  ? 7.511   103.038 9.278   1.00 39.35 ? 342  LEU A CD2   1 
ATOM   364  N N     . ARG A 1 50  ? 6.203   108.114 7.801   1.00 42.32 ? 343  ARG A N     1 
ATOM   365  C CA    . ARG A 1 50  ? 5.243   109.208 7.923   1.00 43.91 ? 343  ARG A CA    1 
ATOM   366  C C     . ARG A 1 50  ? 4.254   109.207 6.756   1.00 41.14 ? 343  ARG A C     1 
ATOM   367  O O     . ARG A 1 50  ? 3.211   109.861 6.833   1.00 40.00 ? 343  ARG A O     1 
ATOM   368  C CB    . ARG A 1 50  ? 5.952   110.571 7.976   1.00 49.96 ? 343  ARG A CB    1 
ATOM   369  C CG    . ARG A 1 50  ? 7.214   110.603 8.830   1.00 59.95 ? 343  ARG A CG    1 
ATOM   370  C CD    . ARG A 1 50  ? 7.909   111.956 8.905   1.00 64.37 ? 343  ARG A CD    1 
ATOM   371  N NE    . ARG A 1 50  ? 7.394   112.795 9.982   1.00 73.57 ? 343  ARG A NE    1 
ATOM   372  C CZ    . ARG A 1 50  ? 7.446   112.492 11.280  1.00 76.29 ? 343  ARG A CZ    1 
ATOM   373  N NH1   . ARG A 1 50  ? 8.099   111.419 11.693  1.00 83.29 ? 343  ARG A NH1   1 
ATOM   374  N NH2   . ARG A 1 50  ? 6.842   113.264 12.167  1.00 75.84 ? 343  ARG A NH2   1 
ATOM   375  N N     . ASP A 1 51  ? 4.573   108.476 5.677   1.00 36.96 ? 344  ASP A N     1 
ATOM   376  C CA    . ASP A 1 51  ? 3.739   108.464 4.482   1.00 37.61 ? 344  ASP A CA    1 
ATOM   377  C C     . ASP A 1 51  ? 2.648   107.393 4.568   1.00 38.76 ? 344  ASP A C     1 
ATOM   378  O O     . ASP A 1 51  ? 1.806   107.321 3.675   1.00 39.14 ? 344  ASP A O     1 
ATOM   379  C CB    . ASP A 1 51  ? 4.576   108.265 3.210   1.00 36.96 ? 344  ASP A CB    1 
ATOM   380  C CG    . ASP A 1 51  ? 5.588   109.374 2.957   1.00 36.92 ? 344  ASP A CG    1 
ATOM   381  O OD1   . ASP A 1 51  ? 5.228   110.559 3.113   1.00 36.09 ? 344  ASP A OD1   1 
ATOM   382  O OD2   . ASP A 1 51  ? 6.736   109.049 2.636   1.00 35.77 ? 344  ASP A OD2   1 
ATOM   383  N N     . LEU A 1 52  ? 2.648   106.578 5.635   1.00 36.26 ? 345  LEU A N     1 
ATOM   384  C CA    . LEU A 1 52  ? 1.620   105.565 5.837   1.00 38.78 ? 345  LEU A CA    1 
ATOM   385  C C     . LEU A 1 52  ? 0.580   106.073 6.840   1.00 35.57 ? 345  LEU A C     1 
ATOM   386  O O     . LEU A 1 52  ? 0.930   106.622 7.874   1.00 33.71 ? 345  LEU A O     1 
ATOM   387  C CB    . LEU A 1 52  ? 2.273   104.282 6.364   1.00 39.71 ? 345  LEU A CB    1 
ATOM   388  C CG    . LEU A 1 52  ? 3.407   103.705 5.515   1.00 41.10 ? 345  LEU A CG    1 
ATOM   389  C CD1   . LEU A 1 52  ? 4.010   102.464 6.174   1.00 40.44 ? 345  LEU A CD1   1 
ATOM   390  C CD2   . LEU A 1 52  ? 2.912   103.379 4.117   1.00 42.03 ? 345  LEU A CD2   1 
ATOM   391  N N     . LYS A 1 53  ? -0.695  105.868 6.520   1.00 38.38 ? 346  LYS A N     1 
ATOM   392  C CA    . LYS A 1 53  ? -1.793  106.150 7.433   1.00 44.75 ? 346  LYS A CA    1 
ATOM   393  C C     . LYS A 1 53  ? -1.907  105.030 8.468   1.00 41.64 ? 346  LYS A C     1 
ATOM   394  O O     . LYS A 1 53  ? -2.177  105.297 9.634   1.00 34.83 ? 346  LYS A O     1 
ATOM   395  C CB    . LYS A 1 53  ? -3.102  106.307 6.653   1.00 47.68 ? 346  LYS A CB    1 
ATOM   396  C CG    . LYS A 1 53  ? -3.199  107.590 5.838   1.00 52.45 ? 346  LYS A CG    1 
ATOM   397  C CD    . LYS A 1 53  ? -4.583  107.857 5.276   1.00 56.92 ? 346  LYS A CD    1 
ATOM   398  C CE    . LYS A 1 53  ? -4.636  109.130 4.458   1.00 64.78 ? 346  LYS A CE    1 
ATOM   399  N NZ    . LYS A 1 53  ? -6.030  109.564 4.208   1.00 68.60 ? 346  LYS A NZ    1 
ATOM   400  N N     . GLU A 1 54  ? -1.688  103.785 8.027   1.00 39.17 ? 347  GLU A N     1 
ATOM   401  C CA    . GLU A 1 54  ? -1.666  102.637 8.916   1.00 39.43 ? 347  GLU A CA    1 
ATOM   402  C C     . GLU A 1 54  ? -0.690  101.598 8.373   1.00 37.97 ? 347  GLU A C     1 
ATOM   403  O O     . GLU A 1 54  ? -0.240  101.684 7.236   1.00 36.58 ? 347  GLU A O     1 
ATOM   404  C CB    . GLU A 1 54  ? -3.072  102.053 9.043   1.00 41.31 ? 347  GLU A CB    1 
ATOM   405  C CG    . GLU A 1 54  ? -3.760  101.924 7.710   1.00 46.61 ? 347  GLU A CG    1 
ATOM   406  C CD    . GLU A 1 54  ? -4.907  100.933 7.644   1.00 52.11 ? 347  GLU A CD    1 
ATOM   407  O OE1   . GLU A 1 54  ? -5.394  100.493 8.706   1.00 47.30 ? 347  GLU A OE1   1 
ATOM   408  O OE2   . GLU A 1 54  ? -5.288  100.586 6.509   1.00 61.62 ? 347  GLU A OE2   1 
ATOM   409  N N     . ALA A 1 55  ? -0.354  100.627 9.219   1.00 32.34 ? 348  ALA A N     1 
ATOM   410  C CA    . ALA A 1 55  ? 0.431   99.486  8.800   1.00 31.08 ? 348  ALA A CA    1 
ATOM   411  C C     . ALA A 1 55  ? -0.521  98.336  8.468   1.00 32.44 ? 348  ALA A C     1 
ATOM   412  O O     . ALA A 1 55  ? -1.124  97.757  9.380   1.00 32.00 ? 348  ALA A O     1 
ATOM   413  C CB    . ALA A 1 55  ? 1.383   99.122  9.909   1.00 30.80 ? 348  ALA A CB    1 
ATOM   414  N N     . ARG A 1 56  ? -0.699  98.042  7.171   1.00 30.47 ? 349  ARG A N     1 
ATOM   415  C CA    . ARG A 1 56  ? -1.486  96.888  6.750   1.00 30.84 ? 349  ARG A CA    1 
ATOM   416  C C     . ARG A 1 56  ? -0.533  95.914  6.089   1.00 29.34 ? 349  ARG A C     1 
ATOM   417  O O     . ARG A 1 56  ? 0.101   96.273  5.110   1.00 29.76 ? 349  ARG A O     1 
ATOM   418  C CB    . ARG A 1 56  ? -2.538  97.169  5.669   1.00 33.21 ? 349  ARG A CB    1 
ATOM   419  C CG    . ARG A 1 56  ? -3.314  98.467  5.823   1.00 41.37 ? 349  ARG A CG    1 
ATOM   420  C CD    . ARG A 1 56  ? -4.204  98.652  4.603   1.00 41.10 ? 349  ARG A CD    1 
ATOM   421  N NE    . ARG A 1 56  ? -5.192  97.593  4.515   1.00 41.61 ? 349  ARG A NE    1 
ATOM   422  C CZ    . ARG A 1 56  ? -5.810  97.218  3.404   1.00 40.57 ? 349  ARG A CZ    1 
ATOM   423  N NH1   . ARG A 1 56  ? -5.450  97.719  2.237   1.00 45.44 ? 349  ARG A NH1   1 
ATOM   424  N NH2   . ARG A 1 56  ? -6.776  96.322  3.460   1.00 41.67 ? 349  ARG A NH2   1 
ATOM   425  N N     . GLY A 1 57  ? -0.458  94.691  6.600   1.00 28.15 ? 350  GLY A N     1 
ATOM   426  C CA    . GLY A 1 57  ? 0.530   93.756  6.103   1.00 27.82 ? 350  GLY A CA    1 
ATOM   427  C C     . GLY A 1 57  ? 0.871   92.705  7.146   1.00 26.01 ? 350  GLY A C     1 
ATOM   428  O O     . GLY A 1 57  ? 0.390   92.756  8.279   1.00 25.44 ? 350  GLY A O     1 
ATOM   429  N N     . LEU A 1 58  ? 1.697   91.748  6.719   1.00 25.48 ? 351  LEU A N     1 
ATOM   430  C CA    . LEU A 1 58  ? 2.233   90.732  7.612   1.00 27.02 ? 351  LEU A CA    1 
ATOM   431  C C     . LEU A 1 58  ? 2.966   91.419  8.759   1.00 25.61 ? 351  LEU A C     1 
ATOM   432  O O     . LEU A 1 58  ? 3.752   92.344  8.531   1.00 26.72 ? 351  LEU A O     1 
ATOM   433  C CB    . LEU A 1 58  ? 3.156   89.813  6.804   1.00 25.90 ? 351  LEU A CB    1 
ATOM   434  C CG    . LEU A 1 58  ? 2.442   88.899  5.814   1.00 25.84 ? 351  LEU A CG    1 
ATOM   435  C CD1   . LEU A 1 58  ? 3.407   88.326  4.780   1.00 27.56 ? 351  LEU A CD1   1 
ATOM   436  C CD2   . LEU A 1 58  ? 1.733   87.774  6.554   1.00 26.47 ? 351  LEU A CD2   1 
ATOM   437  N N     . LEU A 1 59  ? 2.661   90.985  9.993   1.00 26.08 ? 352  LEU A N     1 
ATOM   438  C CA    . LEU A 1 59  ? 3.307   91.484  11.202  1.00 25.40 ? 352  LEU A CA    1 
ATOM   439  C C     . LEU A 1 59  ? 3.140   92.999  11.340  1.00 24.75 ? 352  LEU A C     1 
ATOM   440  O O     . LEU A 1 59  ? 4.057   93.690  11.777  1.00 24.10 ? 352  LEU A O     1 
ATOM   441  C CB    . LEU A 1 59  ? 4.800   91.120  11.174  1.00 26.70 ? 352  LEU A CB    1 
ATOM   442  C CG    . LEU A 1 59  ? 5.121   89.638  10.990  1.00 29.53 ? 352  LEU A CG    1 
ATOM   443  C CD1   . LEU A 1 59  ? 6.631   89.399  11.032  1.00 32.10 ? 352  LEU A CD1   1 
ATOM   444  C CD2   . LEU A 1 59  ? 4.414   88.801  12.053  1.00 31.60 ? 352  LEU A CD2   1 
ATOM   445  N N     . ALA A 1 60  ? 1.964   93.517  10.978  1.00 24.65 ? 353  ALA A N     1 
ATOM   446  C CA    . ALA A 1 60  ? 1.711   94.948  11.007  1.00 25.27 ? 353  ALA A CA    1 
ATOM   447  C C     . ALA A 1 60  ? 1.944   95.524  12.407  1.00 25.85 ? 353  ALA A C     1 
ATOM   448  O O     . ALA A 1 60  ? 2.531   96.602  12.546  1.00 25.50 ? 353  ALA A O     1 
ATOM   449  C CB    . ALA A 1 60  ? 0.292   95.217  10.531  1.00 26.59 ? 353  ALA A CB    1 
ATOM   450  N N     . LYS A 1 61  ? 1.553   94.785  13.462  1.00 26.17 ? 354  LYS A N     1 
ATOM   451  C CA    . LYS A 1 61  ? 1.762   95.267  14.824  1.00 26.92 ? 354  LYS A CA    1 
ATOM   452  C C     . LYS A 1 61  ? 3.226   95.592  15.114  1.00 26.97 ? 354  LYS A C     1 
ATOM   453  O O     . LYS A 1 61  ? 3.512   96.588  15.791  1.00 25.02 ? 354  LYS A O     1 
ATOM   454  C CB    . LYS A 1 61  ? 1.250   94.283  15.881  1.00 29.22 ? 354  LYS A CB    1 
ATOM   455  C CG    . LYS A 1 61  ? 1.729   94.594  17.294  1.00 30.91 ? 354  LYS A CG    1 
ATOM   456  C CD    . LYS A 1 61  ? 1.168   93.710  18.370  1.00 32.92 ? 354  LYS A CD    1 
ATOM   457  C CE    . LYS A 1 61  ? 1.490   92.240  18.197  1.00 32.02 ? 354  LYS A CE    1 
ATOM   458  N NZ    . LYS A 1 61  ? 2.896   91.909  18.514  1.00 31.33 ? 354  LYS A NZ    1 
ATOM   459  N N     . ASP A 1 62  ? 4.149   94.726  14.666  1.00 26.74 ? 355  ASP A N     1 
ATOM   460  C CA    . ASP A 1 62  ? 5.562   94.920  14.944  1.00 28.74 ? 355  ASP A CA    1 
ATOM   461  C C     . ASP A 1 62  ? 6.057   96.249  14.359  1.00 27.47 ? 355  ASP A C     1 
ATOM   462  O O     . ASP A 1 62  ? 6.838   96.960  14.994  1.00 30.01 ? 355  ASP A O     1 
ATOM   463  C CB    . ASP A 1 62  ? 6.396   93.736  14.434  1.00 31.78 ? 355  ASP A CB    1 
ATOM   464  C CG    . ASP A 1 62  ? 6.313   92.486  15.304  1.00 34.01 ? 355  ASP A CG    1 
ATOM   465  O OD1   . ASP A 1 62  ? 5.701   92.552  16.396  1.00 37.69 ? 355  ASP A OD1   1 
ATOM   466  O OD2   . ASP A 1 62  ? 6.846   91.451  14.878  1.00 38.49 ? 355  ASP A OD2   1 
ATOM   467  N N     . LEU A 1 63  ? 5.647   96.580  13.138  1.00 27.71 ? 356  LEU A N     1 
ATOM   468  C CA    . LEU A 1 63  ? 6.034   97.860  12.559  1.00 28.38 ? 356  LEU A CA    1 
ATOM   469  C C     . LEU A 1 63  ? 5.390   99.016  13.331  1.00 28.52 ? 356  LEU A C     1 
ATOM   470  O O     . LEU A 1 63  ? 6.002   100.072 13.497  1.00 28.40 ? 356  LEU A O     1 
ATOM   471  C CB    . LEU A 1 63  ? 5.633   97.917  11.084  1.00 28.53 ? 356  LEU A CB    1 
ATOM   472  C CG    . LEU A 1 63  ? 6.042   99.211  10.377  1.00 29.84 ? 356  LEU A CG    1 
ATOM   473  C CD1   . LEU A 1 63  ? 7.550   99.371  10.420  1.00 31.42 ? 356  LEU A CD1   1 
ATOM   474  C CD2   . LEU A 1 63  ? 5.551   99.246  8.939   1.00 30.24 ? 356  LEU A CD2   1 
ATOM   475  N N     . SER A 1 64  ? 4.137   98.830  13.760  1.00 28.82 ? 357  SER A N     1 
ATOM   476  C CA    . SER A 1 64  ? 3.434   99.850  14.527  1.00 30.72 ? 357  SER A CA    1 
ATOM   477  C C     . SER A 1 64  ? 4.151   100.134 15.850  1.00 32.22 ? 357  SER A C     1 
ATOM   478  O O     . SER A 1 64  ? 4.221   101.287 16.294  1.00 31.37 ? 357  SER A O     1 
ATOM   479  C CB    . SER A 1 64  ? 1.973   99.476  14.715  1.00 31.62 ? 357  SER A CB    1 
ATOM   480  O OG    . SER A 1 64  ? 1.345   100.340 15.660  1.00 35.41 ? 357  SER A OG    1 
ATOM   481  N N     . VAL A 1 65  ? 4.738   99.087  16.461  1.00 30.88 ? 358  VAL A N     1 
ATOM   482  C CA    . VAL A 1 65  ? 5.463   99.252  17.707  1.00 28.97 ? 358  VAL A CA    1 
ATOM   483  C C     . VAL A 1 65  ? 6.692   100.127 17.459  1.00 28.93 ? 358  VAL A C     1 
ATOM   484  O O     . VAL A 1 65  ? 6.975   101.028 18.243  1.00 31.04 ? 358  VAL A O     1 
ATOM   485  C CB    . VAL A 1 65  ? 5.840   97.903  18.349  1.00 29.04 ? 358  VAL A CB    1 
ATOM   486  C CG1   . VAL A 1 65  ? 6.890   98.061  19.443  1.00 28.83 ? 358  VAL A CG1   1 
ATOM   487  C CG2   . VAL A 1 65  ? 4.608   97.193  18.887  1.00 28.84 ? 358  VAL A CG2   1 
ATOM   488  N N     . LEU A 1 66  ? 7.434   99.843  16.393  1.00 29.04 ? 359  LEU A N     1 
ATOM   489  C CA    . LEU A 1 66  ? 8.661   100.575 16.111  1.00 29.91 ? 359  LEU A CA    1 
ATOM   490  C C     . LEU A 1 66  ? 8.311   102.023 15.775  1.00 29.22 ? 359  LEU A C     1 
ATOM   491  O O     . LEU A 1 66  ? 9.033   102.947 16.137  1.00 30.67 ? 359  LEU A O     1 
ATOM   492  C CB    . LEU A 1 66  ? 9.425   99.880  14.976  1.00 29.80 ? 359  LEU A CB    1 
ATOM   493  C CG    . LEU A 1 66  ? 10.673  100.602 14.461  1.00 30.48 ? 359  LEU A CG    1 
ATOM   494  C CD1   . LEU A 1 66  ? 11.714  99.620  13.961  1.00 28.84 ? 359  LEU A CD1   1 
ATOM   495  C CD2   . LEU A 1 66  ? 10.319  101.592 13.355  1.00 32.65 ? 359  LEU A CD2   1 
ATOM   496  N N     . ALA A 1 67  ? 7.205   102.212 15.061  1.00 30.22 ? 360  ALA A N     1 
ATOM   497  C CA    . ALA A 1 67  ? 6.733   103.549 14.745  1.00 30.24 ? 360  ALA A CA    1 
ATOM   498  C C     . ALA A 1 67  ? 6.471   104.327 16.032  1.00 34.13 ? 360  ALA A C     1 
ATOM   499  O O     . ALA A 1 67  ? 6.908   105.472 16.179  1.00 32.72 ? 360  ALA A O     1 
ATOM   500  C CB    . ALA A 1 67  ? 5.503   103.465 13.888  1.00 28.76 ? 360  ALA A CB    1 
ATOM   501  N N     . LEU A 1 68  ? 5.760   103.694 16.972  1.00 33.46 ? 361  LEU A N     1 
ATOM   502  C CA    . LEU A 1 68  ? 5.456   104.346 18.235  1.00 33.33 ? 361  LEU A CA    1 
ATOM   503  C C     . LEU A 1 68  ? 6.739   104.734 18.952  1.00 30.52 ? 361  LEU A C     1 
ATOM   504  O O     . LEU A 1 68  ? 6.771   105.786 19.578  1.00 31.94 ? 361  LEU A O     1 
ATOM   505  C CB    . LEU A 1 68  ? 4.594   103.427 19.105  1.00 35.67 ? 361  LEU A CB    1 
ATOM   506  C CG    . LEU A 1 68  ? 3.106   103.445 18.771  1.00 36.72 ? 361  LEU A CG    1 
ATOM   507  C CD1   . LEU A 1 68  ? 2.366   102.351 19.536  1.00 37.41 ? 361  LEU A CD1   1 
ATOM   508  C CD2   . LEU A 1 68  ? 2.508   104.817 19.079  1.00 36.16 ? 361  LEU A CD2   1 
ATOM   509  N N     . ARG A 1 69  ? 7.765   103.871 18.876  1.00 29.81 ? 362  ARG A N     1 
ATOM   510  C CA    . ARG A 1 69  ? 9.047   104.119 19.510  1.00 32.83 ? 362  ARG A CA    1 
ATOM   511  C C     . ARG A 1 69  ? 9.672   105.404 18.952  1.00 35.33 ? 362  ARG A C     1 
ATOM   512  O O     . ARG A 1 69  ? 10.331  106.134 19.680  1.00 32.38 ? 362  ARG A O     1 
ATOM   513  C CB    . ARG A 1 69  ? 9.991   102.926 19.321  1.00 32.69 ? 362  ARG A CB    1 
ATOM   514  C CG    . ARG A 1 69  ? 11.374  103.098 19.937  1.00 35.01 ? 362  ARG A CG    1 
ATOM   515  C CD    . ARG A 1 69  ? 12.429  102.146 19.394  1.00 35.43 ? 362  ARG A CD    1 
ATOM   516  N NE    . ARG A 1 69  ? 12.825  102.457 18.020  1.00 33.09 ? 362  ARG A NE    1 
ATOM   517  C CZ    . ARG A 1 69  ? 13.381  101.595 17.177  1.00 34.06 ? 362  ARG A CZ    1 
ATOM   518  N NH1   . ARG A 1 69  ? 13.421  100.299 17.456  1.00 34.50 ? 362  ARG A NH1   1 
ATOM   519  N NH2   . ARG A 1 69  ? 13.864  102.030 16.026  1.00 36.41 ? 362  ARG A NH2   1 
ATOM   520  N N     . GLU A 1 70  ? 9.462   105.662 17.659  1.00 35.69 ? 363  GLU A N     1 
ATOM   521  C CA    . GLU A 1 70  ? 9.985   106.837 16.976  1.00 38.14 ? 363  GLU A CA    1 
ATOM   522  C C     . GLU A 1 70  ? 9.038   108.037 17.083  1.00 40.71 ? 363  GLU A C     1 
ATOM   523  O O     . GLU A 1 70  ? 9.233   109.034 16.395  1.00 44.71 ? 363  GLU A O     1 
ATOM   524  C CB    . GLU A 1 70  ? 10.218  106.474 15.509  1.00 38.65 ? 363  GLU A CB    1 
ATOM   525  C CG    . GLU A 1 70  ? 11.241  105.374 15.323  1.00 38.14 ? 363  GLU A CG    1 
ATOM   526  C CD    . GLU A 1 70  ? 12.622  105.725 15.842  1.00 38.95 ? 363  GLU A CD    1 
ATOM   527  O OE1   . GLU A 1 70  ? 13.297  104.831 16.384  1.00 38.31 ? 363  GLU A OE1   1 
ATOM   528  O OE2   . GLU A 1 70  ? 13.010  106.901 15.713  1.00 44.50 ? 363  GLU A OE2   1 
ATOM   529  N N     . GLY A 1 71  ? 8.008   107.951 17.926  1.00 39.37 ? 364  GLY A N     1 
ATOM   530  C CA    . GLY A 1 71  ? 7.141   109.087 18.195  1.00 40.38 ? 364  GLY A CA    1 
ATOM   531  C C     . GLY A 1 71  ? 5.976   109.196 17.217  1.00 41.05 ? 364  GLY A C     1 
ATOM   532  O O     . GLY A 1 71  ? 5.228   110.168 17.248  1.00 41.27 ? 364  GLY A O     1 
ATOM   533  N N     . LEU A 1 72  ? 5.774   108.157 16.407  1.00 42.60 ? 365  LEU A N     1 
ATOM   534  C CA    . LEU A 1 72  ? 4.845   108.224 15.295  1.00 42.60 ? 365  LEU A CA    1 
ATOM   535  C C     . LEU A 1 72  ? 3.626   107.343 15.579  1.00 39.98 ? 365  LEU A C     1 
ATOM   536  O O     . LEU A 1 72  ? 3.767   106.195 15.986  1.00 39.88 ? 365  LEU A O     1 
ATOM   537  C CB    . LEU A 1 72  ? 5.612   107.769 14.050  1.00 45.29 ? 365  LEU A CB    1 
ATOM   538  C CG    . LEU A 1 72  ? 5.083   108.277 12.715  1.00 50.14 ? 365  LEU A CG    1 
ATOM   539  C CD1   . LEU A 1 72  ? 5.225   109.791 12.620  1.00 50.83 ? 365  LEU A CD1   1 
ATOM   540  C CD2   . LEU A 1 72  ? 5.818   107.595 11.568  1.00 53.84 ? 365  LEU A CD2   1 
ATOM   541  N N     . GLY A 1 73  ? 2.431   107.883 15.322  1.00 39.22 ? 366  GLY A N     1 
ATOM   542  C CA    . GLY A 1 73  ? 1.179   107.233 15.671  1.00 41.43 ? 366  GLY A CA    1 
ATOM   543  C C     . GLY A 1 73  ? 0.595   106.437 14.512  1.00 41.56 ? 366  GLY A C     1 
ATOM   544  O O     . GLY A 1 73  ? -0.473  106.773 14.009  1.00 46.51 ? 366  GLY A O     1 
ATOM   545  N N     . LEU A 1 74  ? 1.308   105.376 14.113  1.00 39.43 ? 367  LEU A N     1 
ATOM   546  C CA    . LEU A 1 74  ? 0.944   104.546 12.975  1.00 36.60 ? 367  LEU A CA    1 
ATOM   547  C C     . LEU A 1 74  ? 0.255   103.284 13.486  1.00 38.09 ? 367  LEU A C     1 
ATOM   548  O O     . LEU A 1 74  ? 0.928   102.367 13.953  1.00 35.54 ? 367  LEU A O     1 
ATOM   549  C CB    . LEU A 1 74  ? 2.230   104.217 12.206  1.00 37.59 ? 367  LEU A CB    1 
ATOM   550  C CG    . LEU A 1 74  ? 2.093   103.312 10.982  1.00 37.08 ? 367  LEU A CG    1 
ATOM   551  C CD1   . LEU A 1 74  ? 1.356   104.025 9.862   1.00 39.76 ? 367  LEU A CD1   1 
ATOM   552  C CD2   . LEU A 1 74  ? 3.461   102.862 10.500  1.00 37.48 ? 367  LEU A CD2   1 
ATOM   553  N N     . PRO A 1 75  ? -1.095  103.193 13.446  1.00 38.32 ? 368  PRO A N     1 
ATOM   554  C CA    . PRO A 1 75  ? -1.791  101.990 13.910  1.00 36.33 ? 368  PRO A CA    1 
ATOM   555  C C     . PRO A 1 75  ? -1.683  100.805 12.955  1.00 34.44 ? 368  PRO A C     1 
ATOM   556  O O     . PRO A 1 75  ? -1.614  100.978 11.744  1.00 34.32 ? 368  PRO A O     1 
ATOM   557  C CB    . PRO A 1 75  ? -3.266  102.420 13.984  1.00 35.19 ? 368  PRO A CB    1 
ATOM   558  C CG    . PRO A 1 75  ? -3.373  103.534 12.970  1.00 35.64 ? 368  PRO A CG    1 
ATOM   559  C CD    . PRO A 1 75  ? -2.031  104.243 12.996  1.00 35.69 ? 368  PRO A CD    1 
ATOM   560  N N     . PRO A 1 76  ? -1.725  99.554  13.461  1.00 33.04 ? 369  PRO A N     1 
ATOM   561  C CA    . PRO A 1 76  ? -1.754  98.387  12.587  1.00 31.00 ? 369  PRO A CA    1 
ATOM   562  C C     . PRO A 1 76  ? -3.195  98.189  12.130  1.00 31.71 ? 369  PRO A C     1 
ATOM   563  O O     . PRO A 1 76  ? -4.133  98.433  12.891  1.00 30.27 ? 369  PRO A O     1 
ATOM   564  C CB    . PRO A 1 76  ? -1.248  97.278  13.515  1.00 29.64 ? 369  PRO A CB    1 
ATOM   565  C CG    . PRO A 1 76  ? -1.833  97.662  14.859  1.00 30.08 ? 369  PRO A CG    1 
ATOM   566  C CD    . PRO A 1 76  ? -1.782  99.179  14.883  1.00 32.22 ? 369  PRO A CD    1 
ATOM   567  N N     . GLY A 1 77  ? -3.345  97.748  10.881  1.00 32.51 ? 370  GLY A N     1 
ATOM   568  C CA    . GLY A 1 77  ? -4.641  97.427  10.317  1.00 34.17 ? 370  GLY A CA    1 
ATOM   569  C C     . GLY A 1 77  ? -4.707  95.945  9.971   1.00 34.22 ? 370  GLY A C     1 
ATOM   570  O O     . GLY A 1 77  ? -4.308  95.097  10.776  1.00 35.58 ? 370  GLY A O     1 
ATOM   571  N N     . ASP A 1 78  ? -5.157  95.649  8.753   1.00 31.01 ? 371  ASP A N     1 
ATOM   572  C CA    . ASP A 1 78  ? -5.280  94.273  8.312   1.00 30.67 ? 371  ASP A CA    1 
ATOM   573  C C     . ASP A 1 78  ? -3.900  93.617  8.334   1.00 28.98 ? 371  ASP A C     1 
ATOM   574  O O     . ASP A 1 78  ? -2.888  94.251  8.029   1.00 26.26 ? 371  ASP A O     1 
ATOM   575  C CB    . ASP A 1 78  ? -5.909  94.163  6.923   1.00 33.57 ? 371  ASP A CB    1 
ATOM   576  C CG    . ASP A 1 78  ? -7.352  94.637  6.838   1.00 35.27 ? 371  ASP A CG    1 
ATOM   577  O OD1   . ASP A 1 78  ? -8.218  94.075  7.566   1.00 31.31 ? 371  ASP A OD1   1 
ATOM   578  O OD2   . ASP A 1 78  ? -7.601  95.541  6.008   1.00 35.92 ? 371  ASP A OD2   1 
ATOM   579  N N     . ASP A 1 79  ? -3.884  92.353  8.756   1.00 26.12 ? 372  ASP A N     1 
ATOM   580  C CA    . ASP A 1 79  ? -2.685  91.535  8.778   1.00 25.87 ? 372  ASP A CA    1 
ATOM   581  C C     . ASP A 1 79  ? -3.142  90.128  8.411   1.00 26.26 ? 372  ASP A C     1 
ATOM   582  O O     . ASP A 1 79  ? -3.930  89.509  9.135   1.00 25.70 ? 372  ASP A O     1 
ATOM   583  C CB    . ASP A 1 79  ? -1.985  91.637  10.134  1.00 26.22 ? 372  ASP A CB    1 
ATOM   584  C CG    . ASP A 1 79  ? -0.763  90.740  10.328  1.00 26.30 ? 372  ASP A CG    1 
ATOM   585  O OD1   . ASP A 1 79  ? -0.513  89.865  9.471   1.00 26.47 ? 372  ASP A OD1   1 
ATOM   586  O OD2   . ASP A 1 79  ? -0.066  90.915  11.370  1.00 28.28 ? 372  ASP A OD2   1 
ATOM   587  N N     . PRO A 1 80  ? -2.689  89.596  7.256   1.00 24.33 ? 373  PRO A N     1 
ATOM   588  C CA    . PRO A 1 80  ? -3.084  88.261  6.818   1.00 25.52 ? 373  PRO A CA    1 
ATOM   589  C C     . PRO A 1 80  ? -2.803  87.181  7.857   1.00 23.96 ? 373  PRO A C     1 
ATOM   590  O O     . PRO A 1 80  ? -3.472  86.145  7.856   1.00 25.84 ? 373  PRO A O     1 
ATOM   591  C CB    . PRO A 1 80  ? -2.245  87.994  5.554   1.00 27.49 ? 373  PRO A CB    1 
ATOM   592  C CG    . PRO A 1 80  ? -1.754  89.356  5.109   1.00 27.00 ? 373  PRO A CG    1 
ATOM   593  C CD    . PRO A 1 80  ? -1.775  90.258  6.323   1.00 26.02 ? 373  PRO A CD    1 
ATOM   594  N N     . MET A 1 81  ? -1.830  87.417  8.740   1.00 22.70 ? 374  MET A N     1 
ATOM   595  C CA    . MET A 1 81  ? -1.511  86.441  9.785   1.00 25.21 ? 374  MET A CA    1 
ATOM   596  C C     . MET A 1 81  ? -2.739  86.187  10.668  1.00 25.04 ? 374  MET A C     1 
ATOM   597  O O     . MET A 1 81  ? -2.983  85.047  11.075  1.00 22.75 ? 374  MET A O     1 
ATOM   598  C CB    . MET A 1 81  ? -0.367  86.899  10.697  1.00 26.38 ? 374  MET A CB    1 
ATOM   599  C CG    . MET A 1 81  ? 1.030   86.782  10.107  1.00 27.77 ? 374  MET A CG    1 
ATOM   600  S SD    . MET A 1 81  ? 1.422   85.144  9.461   1.00 27.65 ? 374  MET A SD    1 
ATOM   601  C CE    . MET A 1 81  ? 1.237   84.112  10.911  1.00 27.53 ? 374  MET A CE    1 
ATOM   602  N N     . LEU A 1 82  ? -3.495  87.256  10.968  1.00 22.98 ? 375  LEU A N     1 
ATOM   603  C CA    . LEU A 1 82  ? -4.658  87.157  11.837  1.00 24.95 ? 375  LEU A CA    1 
ATOM   604  C C     . LEU A 1 82  ? -5.750  86.334  11.152  1.00 24.31 ? 375  LEU A C     1 
ATOM   605  O O     . LEU A 1 82  ? -6.393  85.501  11.797  1.00 25.75 ? 375  LEU A O     1 
ATOM   606  C CB    . LEU A 1 82  ? -5.142  88.574  12.178  1.00 26.72 ? 375  LEU A CB    1 
ATOM   607  C CG    . LEU A 1 82  ? -4.152  89.436  12.963  1.00 27.04 ? 375  LEU A CG    1 
ATOM   608  C CD1   . LEU A 1 82  ? -4.759  90.778  13.347  1.00 27.43 ? 375  LEU A CD1   1 
ATOM   609  C CD2   . LEU A 1 82  ? -3.665  88.708  14.206  1.00 28.11 ? 375  LEU A CD2   1 
ATOM   610  N N     . LEU A 1 83  ? -5.928  86.550  9.838   1.00 25.09 ? 376  LEU A N     1 
ATOM   611  C CA    . LEU A 1 83  ? -6.865  85.785  9.020   1.00 24.83 ? 376  LEU A CA    1 
ATOM   612  C C     . LEU A 1 83  ? -6.462  84.313  9.021   1.00 24.29 ? 376  LEU A C     1 
ATOM   613  O O     . LEU A 1 83  ? -7.301  83.441  9.220   1.00 24.27 ? 376  LEU A O     1 
ATOM   614  C CB    . LEU A 1 83  ? -6.893  86.309  7.574   1.00 25.75 ? 376  LEU A CB    1 
ATOM   615  C CG    . LEU A 1 83  ? -7.359  87.755  7.359   1.00 25.77 ? 376  LEU A CG    1 
ATOM   616  C CD1   . LEU A 1 83  ? -7.250  88.124  5.883   1.00 26.43 ? 376  LEU A CD1   1 
ATOM   617  C CD2   . LEU A 1 83  ? -8.789  87.967  7.849   1.00 27.43 ? 376  LEU A CD2   1 
ATOM   618  N N     . ALA A 1 84  ? -5.184  84.030  8.758   1.00 23.57 ? 377  ALA A N     1 
ATOM   619  C CA    . ALA A 1 84  ? -4.732  82.644  8.722   1.00 22.67 ? 377  ALA A CA    1 
ATOM   620  C C     . ALA A 1 84  ? -4.902  81.966  10.082  1.00 21.67 ? 377  ALA A C     1 
ATOM   621  O O     . ALA A 1 84  ? -5.321  80.807  10.149  1.00 22.47 ? 377  ALA A O     1 
ATOM   622  C CB    . ALA A 1 84  ? -3.308  82.572  8.251   1.00 21.42 ? 377  ALA A CB    1 
ATOM   623  N N     . TYR A 1 85  ? -4.579  82.695  11.160  1.00 20.58 ? 378  TYR A N     1 
ATOM   624  C CA    . TYR A 1 85  ? -4.655  82.164  12.519  1.00 22.01 ? 378  TYR A CA    1 
ATOM   625  C C     . TYR A 1 85  ? -6.081  81.755  12.889  1.00 22.25 ? 378  TYR A C     1 
ATOM   626  O O     . TYR A 1 85  ? -6.282  80.734  13.574  1.00 20.02 ? 378  TYR A O     1 
ATOM   627  C CB    . TYR A 1 85  ? -4.104  83.196  13.501  1.00 22.24 ? 378  TYR A CB    1 
ATOM   628  C CG    . TYR A 1 85  ? -4.047  82.764  14.941  1.00 20.25 ? 378  TYR A CG    1 
ATOM   629  C CD1   . TYR A 1 85  ? -3.215  81.723  15.341  1.00 20.43 ? 378  TYR A CD1   1 
ATOM   630  C CD2   . TYR A 1 85  ? -4.809  83.403  15.905  1.00 20.22 ? 378  TYR A CD2   1 
ATOM   631  C CE1   . TYR A 1 85  ? -3.169  81.321  16.662  1.00 19.75 ? 378  TYR A CE1   1 
ATOM   632  C CE2   . TYR A 1 85  ? -4.750  83.034  17.236  1.00 21.66 ? 378  TYR A CE2   1 
ATOM   633  C CZ    . TYR A 1 85  ? -3.921  81.984  17.611  1.00 21.40 ? 378  TYR A CZ    1 
ATOM   634  O OH    . TYR A 1 85  ? -3.867  81.597  18.909  1.00 22.33 ? 378  TYR A OH    1 
ATOM   635  N N     . LEU A 1 86  ? -7.054  82.593  12.468  1.00 21.43 ? 379  LEU A N     1 
ATOM   636  C CA    . LEU A 1 86  ? -8.465  82.331  12.700  1.00 23.19 ? 379  LEU A CA    1 
ATOM   637  C C     . LEU A 1 86  ? -8.943  81.106  11.917  1.00 23.60 ? 379  LEU A C     1 
ATOM   638  O O     . LEU A 1 86  ? -9.703  80.303  12.455  1.00 26.35 ? 379  LEU A O     1 
ATOM   639  C CB    . LEU A 1 86  ? -9.274  83.590  12.350  1.00 22.90 ? 379  LEU A CB    1 
ATOM   640  C CG    . LEU A 1 86  ? -9.225  84.691  13.408  1.00 23.60 ? 379  LEU A CG    1 
ATOM   641  C CD1   . LEU A 1 86  ? -9.894  85.974  12.922  1.00 25.59 ? 379  LEU A CD1   1 
ATOM   642  C CD2   . LEU A 1 86  ? -9.863  84.220  14.701  1.00 24.76 ? 379  LEU A CD2   1 
ATOM   643  N N     . LEU A 1 87  ? -8.489  80.950  10.667  1.00 24.33 ? 380  LEU A N     1 
ATOM   644  C CA    . LEU A 1 87  ? -8.839  79.784  9.866   1.00 27.25 ? 380  LEU A CA    1 
ATOM   645  C C     . LEU A 1 87  ? -8.302  78.502  10.509  1.00 28.94 ? 380  LEU A C     1 
ATOM   646  O O     . LEU A 1 87  ? -8.966  77.456  10.464  1.00 29.85 ? 380  LEU A O     1 
ATOM   647  C CB    . LEU A 1 87  ? -8.281  79.942  8.444   1.00 28.39 ? 380  LEU A CB    1 
ATOM   648  C CG    . LEU A 1 87  ? -8.996  80.953  7.538   1.00 28.86 ? 380  LEU A CG    1 
ATOM   649  C CD1   . LEU A 1 87  ? -8.210  81.185  6.253   1.00 29.21 ? 380  LEU A CD1   1 
ATOM   650  C CD2   . LEU A 1 87  ? -10.412 80.493  7.202   1.00 29.42 ? 380  LEU A CD2   1 
ATOM   651  N N     . ASP A 1 88  ? -7.094  78.595  11.078  1.00 25.16 ? 381  ASP A N     1 
ATOM   652  C CA    . ASP A 1 88  ? -6.407  77.445  11.648  1.00 26.48 ? 381  ASP A CA    1 
ATOM   653  C C     . ASP A 1 88  ? -5.292  77.957  12.560  1.00 25.20 ? 381  ASP A C     1 
ATOM   654  O O     . ASP A 1 88  ? -4.302  78.495  12.078  1.00 26.69 ? 381  ASP A O     1 
ATOM   655  C CB    . ASP A 1 88  ? -5.884  76.547  10.524  1.00 26.75 ? 381  ASP A CB    1 
ATOM   656  C CG    . ASP A 1 88  ? -5.184  75.277  10.982  1.00 26.19 ? 381  ASP A CG    1 
ATOM   657  O OD1   . ASP A 1 88  ? -5.053  75.071  12.193  1.00 26.70 ? 381  ASP A OD1   1 
ATOM   658  O OD2   . ASP A 1 88  ? -4.809  74.501  10.110  1.00 29.02 ? 381  ASP A OD2   1 
ATOM   659  N N     . PRO A 1 89  ? -5.407  77.838  13.903  1.00 24.58 ? 382  PRO A N     1 
ATOM   660  C CA    . PRO A 1 89  ? -4.403  78.408  14.801  1.00 24.96 ? 382  PRO A CA    1 
ATOM   661  C C     . PRO A 1 89  ? -3.043  77.706  14.776  1.00 23.41 ? 382  PRO A C     1 
ATOM   662  O O     . PRO A 1 89  ? -2.103  78.237  15.359  1.00 24.79 ? 382  PRO A O     1 
ATOM   663  C CB    . PRO A 1 89  ? -5.072  78.387  16.180  1.00 25.32 ? 382  PRO A CB    1 
ATOM   664  C CG    . PRO A 1 89  ? -6.120  77.302  16.083  1.00 26.02 ? 382  PRO A CG    1 
ATOM   665  C CD    . PRO A 1 89  ? -6.529  77.226  14.626  1.00 26.78 ? 382  PRO A CD    1 
ATOM   666  N N     . SER A 1 90  ? -2.890  76.625  13.996  1.00 23.44 ? 383  SER A N     1 
ATOM   667  C CA    . SER A 1 90  ? -1.554  76.108  13.702  1.00 25.95 ? 383  SER A CA    1 
ATOM   668  C C     . SER A 1 90  ? -0.815  77.032  12.731  1.00 26.06 ? 383  SER A C     1 
ATOM   669  O O     . SER A 1 90  ? 0.393   76.884  12.532  1.00 26.11 ? 383  SER A O     1 
ATOM   670  C CB    . SER A 1 90  ? -1.587  74.668  13.215  1.00 27.44 ? 383  SER A CB    1 
ATOM   671  O OG    . SER A 1 90  ? -2.131  74.579  11.911  1.00 30.77 ? 383  SER A OG    1 
ATOM   672  N N     . ASN A 1 91  ? -1.516  78.020  12.149  1.00 23.79 ? 384  ASN A N     1 
ATOM   673  C CA    . ASN A 1 91  ? -0.868  79.021  11.311  1.00 25.36 ? 384  ASN A CA    1 
ATOM   674  C C     . ASN A 1 91  ? -0.239  80.105  12.200  1.00 26.55 ? 384  ASN A C     1 
ATOM   675  O O     . ASN A 1 91  ? -0.916  81.046  12.633  1.00 25.73 ? 384  ASN A O     1 
ATOM   676  C CB    . ASN A 1 91  ? -1.849  79.672  10.319  1.00 26.95 ? 384  ASN A CB    1 
ATOM   677  C CG    . ASN A 1 91  ? -2.375  78.742  9.240   1.00 27.46 ? 384  ASN A CG    1 
ATOM   678  O OD1   . ASN A 1 91  ? -1.625  77.931  8.693   1.00 25.87 ? 384  ASN A OD1   1 
ATOM   679  N ND2   . ASN A 1 91  ? -3.663  78.845  8.938   1.00 23.10 ? 384  ASN A ND2   1 
ATOM   680  N N     . THR A 1 92  ? 1.069   79.997  12.465  1.00 26.67 ? 385  THR A N     1 
ATOM   681  C CA    . THR A 1 92  ? 1.675   80.843  13.486  1.00 26.15 ? 385  THR A CA    1 
ATOM   682  C C     . THR A 1 92  ? 2.803   81.726  12.959  1.00 26.34 ? 385  THR A C     1 
ATOM   683  O O     . THR A 1 92  ? 3.179   82.667  13.660  1.00 26.53 ? 385  THR A O     1 
ATOM   684  C CB    . THR A 1 92  ? 2.219   80.008  14.656  1.00 27.20 ? 385  THR A CB    1 
ATOM   685  O OG1   . THR A 1 92  ? 3.193   79.120  14.120  1.00 27.08 ? 385  THR A OG1   1 
ATOM   686  C CG2   . THR A 1 92  ? 1.134   79.247  15.387  1.00 27.81 ? 385  THR A CG2   1 
ATOM   687  N N     . THR A 1 93  ? 3.366   81.435  11.770  1.00 26.18 ? 386  THR A N     1 
ATOM   688  C CA    . THR A 1 93  ? 4.482   82.221  11.253  1.00 28.55 ? 386  THR A CA    1 
ATOM   689  C C     . THR A 1 93  ? 4.219   82.636  9.811   1.00 28.47 ? 386  THR A C     1 
ATOM   690  O O     . THR A 1 93  ? 3.539   81.933  9.070   1.00 28.28 ? 386  THR A O     1 
ATOM   691  C CB    . THR A 1 93  ? 5.807   81.430  11.295  1.00 30.23 ? 386  THR A CB    1 
ATOM   692  O OG1   . THR A 1 93  ? 5.755   80.413  10.286  1.00 28.04 ? 386  THR A OG1   1 
ATOM   693  C CG2   . THR A 1 93  ? 6.079   80.806  12.646  1.00 31.58 ? 386  THR A CG2   1 
ATOM   694  N N     . PRO A 1 94  ? 4.788   83.765  9.336   1.00 30.69 ? 387  PRO A N     1 
ATOM   695  C CA    . PRO A 1 94  ? 4.625   84.152  7.933   1.00 30.28 ? 387  PRO A CA    1 
ATOM   696  C C     . PRO A 1 94  ? 5.218   83.147  6.935   1.00 30.20 ? 387  PRO A C     1 
ATOM   697  O O     . PRO A 1 94  ? 4.605   82.883  5.900   1.00 29.28 ? 387  PRO A O     1 
ATOM   698  C CB    . PRO A 1 94  ? 5.279   85.529  7.826   1.00 31.24 ? 387  PRO A CB    1 
ATOM   699  C CG    . PRO A 1 94  ? 6.117   85.690  9.078   1.00 33.25 ? 387  PRO A CG    1 
ATOM   700  C CD    . PRO A 1 94  ? 5.560   84.741  10.122  1.00 30.97 ? 387  PRO A CD    1 
ATOM   701  N N     . GLU A 1 95  ? 6.358   82.540  7.293   1.00 31.93 ? 388  GLU A N     1 
ATOM   702  C CA    . GLU A 1 95  ? 7.025   81.536  6.478   1.00 32.74 ? 388  GLU A CA    1 
ATOM   703  C C     . GLU A 1 95  ? 6.106   80.345  6.269   1.00 29.51 ? 388  GLU A C     1 
ATOM   704  O O     . GLU A 1 95  ? 5.978   79.874  5.146   1.00 30.72 ? 388  GLU A O     1 
ATOM   705  C CB    . GLU A 1 95  ? 8.316   80.976  7.086   1.00 36.42 ? 388  GLU A CB    1 
ATOM   706  C CG    . GLU A 1 95  ? 9.211   82.017  7.719   1.00 45.45 ? 388  GLU A CG    1 
ATOM   707  C CD    . GLU A 1 95  ? 8.883   82.344  9.168   1.00 50.69 ? 388  GLU A CD    1 
ATOM   708  O OE1   . GLU A 1 95  ? 8.418   83.477  9.434   1.00 51.71 ? 388  GLU A OE1   1 
ATOM   709  O OE2   . GLU A 1 95  ? 9.084   81.459  10.030  1.00 58.81 ? 388  GLU A OE2   1 
ATOM   710  N N     . GLY A 1 96  ? 5.508   79.841  7.351   1.00 30.38 ? 389  GLY A N     1 
ATOM   711  C CA    . GLY A 1 96  ? 4.589   78.715  7.250   1.00 30.44 ? 389  GLY A CA    1 
ATOM   712  C C     . GLY A 1 96  ? 3.304   79.058  6.490   1.00 30.91 ? 389  GLY A C     1 
ATOM   713  O O     . GLY A 1 96  ? 2.801   78.247  5.714   1.00 29.52 ? 389  GLY A O     1 
ATOM   714  N N     . VAL A 1 97  ? 2.747   80.255  6.735   1.00 27.55 ? 390  VAL A N     1 
ATOM   715  C CA    . VAL A 1 97  ? 1.527   80.679  6.051   1.00 27.20 ? 390  VAL A CA    1 
ATOM   716  C C     . VAL A 1 97  ? 1.811   80.831  4.552   1.00 29.00 ? 390  VAL A C     1 
ATOM   717  O O     . VAL A 1 97  ? 1.074   80.295  3.724   1.00 26.66 ? 390  VAL A O     1 
ATOM   718  C CB    . VAL A 1 97  ? 0.948   81.951  6.708   1.00 26.94 ? 390  VAL A CB    1 
ATOM   719  C CG1   . VAL A 1 97  ? -0.095  82.665  5.867   1.00 29.23 ? 390  VAL A CG1   1 
ATOM   720  C CG2   . VAL A 1 97  ? 0.390   81.642  8.090   1.00 27.10 ? 390  VAL A CG2   1 
ATOM   721  N N     . ALA A 1 98  ? 2.912   81.504  4.193   1.00 31.21 ? 391  ALA A N     1 
ATOM   722  C CA    . ALA A 1 98  ? 3.312   81.619  2.793   1.00 32.93 ? 391  ALA A CA    1 
ATOM   723  C C     . ALA A 1 98  ? 3.405   80.241  2.123   1.00 32.76 ? 391  ALA A C     1 
ATOM   724  O O     . ALA A 1 98  ? 2.767   80.013  1.101   1.00 36.42 ? 391  ALA A O     1 
ATOM   725  C CB    . ALA A 1 98  ? 4.624   82.364  2.679   1.00 33.99 ? 391  ALA A CB    1 
ATOM   726  N N     . ARG A 1 99  ? 4.191   79.326  2.701   1.00 32.96 ? 392  ARG A N     1 
ATOM   727  C CA    . ARG A 1 99  ? 4.364   77.980  2.174   1.00 35.87 ? 392  ARG A CA    1 
ATOM   728  C C     . ARG A 1 99  ? 3.026   77.270  1.957   1.00 35.14 ? 392  ARG A C     1 
ATOM   729  O O     . ARG A 1 99  ? 2.863   76.523  0.993   1.00 35.01 ? 392  ARG A O     1 
ATOM   730  C CB    . ARG A 1 99  ? 5.241   77.141  3.111   1.00 38.72 ? 392  ARG A CB    1 
ATOM   731  C CG    . ARG A 1 99  ? 6.709   77.086  2.705   1.00 46.17 ? 392  ARG A CG    1 
ATOM   732  C CD    . ARG A 1 99  ? 7.585   76.223  3.605   1.00 51.57 ? 392  ARG A CD    1 
ATOM   733  N NE    . ARG A 1 99  ? 8.533   77.004  4.396   1.00 55.41 ? 392  ARG A NE    1 
ATOM   734  C CZ    . ARG A 1 99  ? 8.561   77.061  5.723   1.00 64.48 ? 392  ARG A CZ    1 
ATOM   735  N NH1   . ARG A 1 99  ? 9.525   77.732  6.331   1.00 74.07 ? 392  ARG A NH1   1 
ATOM   736  N NH2   . ARG A 1 99  ? 7.631   76.455  6.441   1.00 68.40 ? 392  ARG A NH2   1 
ATOM   737  N N     . ARG A 1 100 ? 2.072   77.479  2.862   1.00 31.62 ? 393  ARG A N     1 
ATOM   738  C CA    . ARG A 1 100 ? 0.815   76.745  2.800   1.00 32.10 ? 393  ARG A CA    1 
ATOM   739  C C     . ARG A 1 100 ? -0.168  77.399  1.825   1.00 30.77 ? 393  ARG A C     1 
ATOM   740  O O     . ARG A 1 100 ? -0.893  76.699  1.124   1.00 31.36 ? 393  ARG A O     1 
ATOM   741  C CB    . ARG A 1 100 ? 0.198   76.656  4.198   1.00 29.21 ? 393  ARG A CB    1 
ATOM   742  C CG    . ARG A 1 100 ? -1.156  75.970  4.242   1.00 28.56 ? 393  ARG A CG    1 
ATOM   743  C CD    . ARG A 1 100 ? -1.559  75.797  5.688   1.00 28.40 ? 393  ARG A CD    1 
ATOM   744  N NE    . ARG A 1 100 ? -2.842  75.128  5.818   1.00 27.24 ? 393  ARG A NE    1 
ATOM   745  C CZ    . ARG A 1 100 ? -3.483  74.940  6.960   1.00 27.41 ? 393  ARG A CZ    1 
ATOM   746  N NH1   . ARG A 1 100 ? -4.583  74.203  6.979   1.00 28.81 ? 393  ARG A NH1   1 
ATOM   747  N NH2   . ARG A 1 100 ? -3.039  75.511  8.066   1.00 25.35 ? 393  ARG A NH2   1 
ATOM   748  N N     . TYR A 1 101 ? -0.241  78.735  1.840   1.00 31.58 ? 394  TYR A N     1 
ATOM   749  C CA    . TYR A 1 101 ? -1.311  79.456  1.167   1.00 31.21 ? 394  TYR A CA    1 
ATOM   750  C C     . TYR A 1 101 ? -0.840  80.078  -0.143  1.00 35.95 ? 394  TYR A C     1 
ATOM   751  O O     . TYR A 1 101 ? -1.670  80.437  -0.974  1.00 38.55 ? 394  TYR A O     1 
ATOM   752  C CB    . TYR A 1 101 ? -1.901  80.526  2.084   1.00 30.55 ? 394  TYR A CB    1 
ATOM   753  C CG    . TYR A 1 101 ? -2.739  79.955  3.198   1.00 29.41 ? 394  TYR A CG    1 
ATOM   754  C CD1   . TYR A 1 101 ? -4.053  79.573  2.994   1.00 29.59 ? 394  TYR A CD1   1 
ATOM   755  C CD2   . TYR A 1 101 ? -2.199  79.740  4.451   1.00 30.50 ? 394  TYR A CD2   1 
ATOM   756  C CE1   . TYR A 1 101 ? -4.821  79.040  4.023   1.00 29.40 ? 394  TYR A CE1   1 
ATOM   757  C CE2   . TYR A 1 101 ? -2.944  79.196  5.486   1.00 29.43 ? 394  TYR A CE2   1 
ATOM   758  C CZ    . TYR A 1 101 ? -4.265  78.846  5.278   1.00 28.14 ? 394  TYR A CZ    1 
ATOM   759  O OH    . TYR A 1 101 ? -4.983  78.309  6.325   1.00 27.02 ? 394  TYR A OH    1 
ATOM   760  N N     . GLY A 1 102 ? 0.476   80.234  -0.306  1.00 34.59 ? 395  GLY A N     1 
ATOM   761  C CA    . GLY A 1 102 ? 1.028   80.677  -1.572  1.00 36.95 ? 395  GLY A CA    1 
ATOM   762  C C     . GLY A 1 102 ? 2.070   81.766  -1.364  1.00 37.37 ? 395  GLY A C     1 
ATOM   763  O O     . GLY A 1 102 ? 1.943   82.588  -0.455  1.00 37.16 ? 395  GLY A O     1 
ATOM   764  N N     . GLY A 1 103 ? 3.096   81.744  -2.219  1.00 35.67 ? 396  GLY A N     1 
ATOM   765  C CA    . GLY A 1 103 ? 4.187   82.703  -2.151  1.00 34.36 ? 396  GLY A CA    1 
ATOM   766  C C     . GLY A 1 103 ? 5.297   82.230  -1.216  1.00 33.53 ? 396  GLY A C     1 
ATOM   767  O O     . GLY A 1 103 ? 5.323   81.084  -0.764  1.00 32.63 ? 396  GLY A O     1 
ATOM   768  N N     . GLU A 1 104 ? 6.212   83.149  -0.918  1.00 33.91 ? 397  GLU A N     1 
ATOM   769  C CA    . GLU A 1 104 ? 7.389   82.824  -0.141  1.00 35.93 ? 397  GLU A CA    1 
ATOM   770  C C     . GLU A 1 104 ? 7.790   84.045  0.677   1.00 33.51 ? 397  GLU A C     1 
ATOM   771  O O     . GLU A 1 104 ? 7.929   85.140  0.131   1.00 33.11 ? 397  GLU A O     1 
ATOM   772  C CB    . GLU A 1 104 ? 8.505   82.385  -1.092  1.00 40.75 ? 397  GLU A CB    1 
ATOM   773  C CG    . GLU A 1 104 ? 9.812   82.037  -0.406  1.00 42.31 ? 397  GLU A CG    1 
ATOM   774  C CD    . GLU A 1 104 ? 10.956  81.782  -1.377  1.00 43.84 ? 397  GLU A CD    1 
ATOM   775  O OE1   . GLU A 1 104 ? 10.828  82.173  -2.548  1.00 47.63 ? 397  GLU A OE1   1 
ATOM   776  O OE2   . GLU A 1 104 ? 11.956  81.174  -0.962  1.00 45.75 ? 397  GLU A OE2   1 
ATOM   777  N N     . TRP A 1 105 ? 7.966   83.812  1.985   1.00 31.85 ? 398  TRP A N     1 
ATOM   778  C CA    . TRP A 1 105 ? 8.502   84.787  2.919   1.00 31.93 ? 398  TRP A CA    1 
ATOM   779  C C     . TRP A 1 105 ? 10.014  84.896  2.732   1.00 33.47 ? 398  TRP A C     1 
ATOM   780  O O     . TRP A 1 105 ? 10.737  83.939  2.988   1.00 35.23 ? 398  TRP A O     1 
ATOM   781  C CB    . TRP A 1 105 ? 8.155   84.360  4.350   1.00 30.61 ? 398  TRP A CB    1 
ATOM   782  C CG    . TRP A 1 105 ? 8.707   85.240  5.428   1.00 29.53 ? 398  TRP A CG    1 
ATOM   783  C CD1   . TRP A 1 105 ? 9.769   84.969  6.239   1.00 29.91 ? 398  TRP A CD1   1 
ATOM   784  C CD2   . TRP A 1 105 ? 8.210   86.523  5.838   1.00 29.71 ? 398  TRP A CD2   1 
ATOM   785  N NE1   . TRP A 1 105 ? 9.964   85.993  7.120   1.00 31.29 ? 398  TRP A NE1   1 
ATOM   786  C CE2   . TRP A 1 105 ? 9.022   86.960  6.905   1.00 29.09 ? 398  TRP A CE2   1 
ATOM   787  C CE3   . TRP A 1 105 ? 7.166   87.351  5.407   1.00 29.25 ? 398  TRP A CE3   1 
ATOM   788  C CZ2   . TRP A 1 105 ? 8.818   88.180  7.553   1.00 29.82 ? 398  TRP A CZ2   1 
ATOM   789  C CZ3   . TRP A 1 105 ? 6.968   88.555  6.049   1.00 31.13 ? 398  TRP A CZ3   1 
ATOM   790  C CH2   . TRP A 1 105 ? 7.779   88.964  7.108   1.00 29.71 ? 398  TRP A CH2   1 
ATOM   791  N N     . THR A 1 106 ? 10.484  86.065  2.298   1.00 33.19 ? 399  THR A N     1 
ATOM   792  C CA    . THR A 1 106 ? 11.893  86.262  2.000   1.00 32.73 ? 399  THR A CA    1 
ATOM   793  C C     . THR A 1 106 ? 12.448  87.290  2.981   1.00 33.78 ? 399  THR A C     1 
ATOM   794  O O     . THR A 1 106 ? 11.801  87.615  3.973   1.00 35.31 ? 399  THR A O     1 
ATOM   795  C CB    . THR A 1 106 ? 12.075  86.641  0.526   1.00 33.68 ? 399  THR A CB    1 
ATOM   796  O OG1   . THR A 1 106 ? 11.464  87.912  0.266   1.00 33.59 ? 399  THR A OG1   1 
ATOM   797  C CG2   . THR A 1 106 ? 11.497  85.594  -0.397  1.00 35.12 ? 399  THR A CG2   1 
ATOM   798  N N     . GLU A 1 107 ? 13.640  87.815  2.680   1.00 33.49 ? 400  GLU A N     1 
ATOM   799  C CA    . GLU A 1 107 ? 14.315  88.777  3.535   1.00 36.07 ? 400  GLU A CA    1 
ATOM   800  C C     . GLU A 1 107 ? 14.361  90.150  2.870   1.00 32.75 ? 400  GLU A C     1 
ATOM   801  O O     . GLU A 1 107 ? 15.155  90.992  3.273   1.00 33.56 ? 400  GLU A O     1 
ATOM   802  C CB    . GLU A 1 107 ? 15.719  88.253  3.861   1.00 40.06 ? 400  GLU A CB    1 
ATOM   803  C CG    . GLU A 1 107 ? 15.691  86.949  4.651   1.00 43.82 ? 400  GLU A CG    1 
ATOM   804  C CD    . GLU A 1 107 ? 15.016  87.084  6.008   1.00 46.70 ? 400  GLU A CD    1 
ATOM   805  O OE1   . GLU A 1 107 ? 15.444  87.963  6.784   1.00 51.76 ? 400  GLU A OE1   1 
ATOM   806  O OE2   . GLU A 1 107 ? 14.047  86.332  6.279   1.00 49.22 ? 400  GLU A OE2   1 
ATOM   807  N N     . GLU A 1 108 ? 13.473  90.390  1.905   1.00 32.42 ? 401  GLU A N     1 
ATOM   808  C CA    . GLU A 1 108 ? 13.458  91.641  1.160   1.00 32.20 ? 401  GLU A CA    1 
ATOM   809  C C     . GLU A 1 108 ? 12.101  92.331  1.367   1.00 28.96 ? 401  GLU A C     1 
ATOM   810  O O     . GLU A 1 108 ? 11.052  91.705  1.238   1.00 27.57 ? 401  GLU A O     1 
ATOM   811  C CB    . GLU A 1 108 ? 13.805  91.321  -0.300  1.00 33.89 ? 401  GLU A CB    1 
ATOM   812  C CG    . GLU A 1 108 ? 14.196  92.529  -1.147  1.00 34.96 ? 401  GLU A CG    1 
ATOM   813  C CD    . GLU A 1 108 ? 13.036  93.382  -1.653  1.00 34.35 ? 401  GLU A CD    1 
ATOM   814  O OE1   . GLU A 1 108 ? 13.070  94.625  -1.464  1.00 34.87 ? 401  GLU A OE1   1 
ATOM   815  O OE2   . GLU A 1 108 ? 12.090  92.806  -2.213  1.00 33.67 ? 401  GLU A OE2   1 
ATOM   816  N N     . ALA A 1 109 ? 12.140  93.626  1.696   1.00 29.77 ? 402  ALA A N     1 
ATOM   817  C CA    . ALA A 1 109 ? 10.960  94.397  2.084   1.00 30.74 ? 402  ALA A CA    1 
ATOM   818  C C     . ALA A 1 109 ? 9.911   94.428  0.976   1.00 30.87 ? 402  ALA A C     1 
ATOM   819  O O     . ALA A 1 109 ? 8.724   94.253  1.245   1.00 29.00 ? 402  ALA A O     1 
ATOM   820  C CB    . ALA A 1 109 ? 11.367  95.798  2.457   1.00 29.91 ? 402  ALA A CB    1 
ATOM   821  N N     . GLY A 1 110 ? 10.347  94.681  -0.269  1.00 29.76 ? 403  GLY A N     1 
ATOM   822  C CA    . GLY A 1 110 ? 9.418   94.796  -1.377  1.00 28.82 ? 403  GLY A CA    1 
ATOM   823  C C     . GLY A 1 110 ? 8.669   93.493  -1.636  1.00 29.05 ? 403  GLY A C     1 
ATOM   824  O O     . GLY A 1 110 ? 7.477   93.500  -1.901  1.00 28.15 ? 403  GLY A O     1 
ATOM   825  N N     . GLU A 1 111 ? 9.388   92.374  -1.560  1.00 30.13 ? 404  GLU A N     1 
ATOM   826  C CA    . GLU A 1 111 ? 8.797   91.062  -1.722  1.00 30.77 ? 404  GLU A CA    1 
ATOM   827  C C     . GLU A 1 111 ? 7.821   90.770  -0.579  1.00 31.02 ? 404  GLU A C     1 
ATOM   828  O O     . GLU A 1 111 ? 6.832   90.065  -0.779  1.00 30.24 ? 404  GLU A O     1 
ATOM   829  C CB    . GLU A 1 111 ? 9.913   90.023  -1.795  1.00 32.19 ? 404  GLU A CB    1 
ATOM   830  C CG    . GLU A 1 111 ? 10.619  90.029  -3.135  1.00 36.24 ? 404  GLU A CG    1 
ATOM   831  C CD    . GLU A 1 111 ? 11.776  89.049  -3.237  1.00 38.20 ? 404  GLU A CD    1 
ATOM   832  O OE1   . GLU A 1 111 ? 12.253  88.563  -2.188  1.00 39.00 ? 404  GLU A OE1   1 
ATOM   833  O OE2   . GLU A 1 111 ? 12.183  88.765  -4.363  1.00 41.40 ? 404  GLU A OE2   1 
ATOM   834  N N     . ARG A 1 112 ? 8.096   91.315  0.611   1.00 30.28 ? 405  ARG A N     1 
ATOM   835  C CA    . ARG A 1 112 ? 7.225   91.088  1.760   1.00 32.48 ? 405  ARG A CA    1 
ATOM   836  C C     . ARG A 1 112 ? 5.925   91.881  1.615   1.00 31.49 ? 405  ARG A C     1 
ATOM   837  O O     . ARG A 1 112 ? 4.857   91.410  2.028   1.00 30.04 ? 405  ARG A O     1 
ATOM   838  C CB    . ARG A 1 112 ? 7.956   91.436  3.055   1.00 30.76 ? 405  ARG A CB    1 
ATOM   839  C CG    . ARG A 1 112 ? 8.980   90.396  3.468   1.00 30.77 ? 405  ARG A CG    1 
ATOM   840  C CD    . ARG A 1 112 ? 9.759   90.848  4.681   1.00 32.17 ? 405  ARG A CD    1 
ATOM   841  N NE    . ARG A 1 112 ? 10.708  89.829  5.117   1.00 32.75 ? 405  ARG A NE    1 
ATOM   842  C CZ    . ARG A 1 112 ? 11.354  89.859  6.272   1.00 32.57 ? 405  ARG A CZ    1 
ATOM   843  N NH1   . ARG A 1 112 ? 11.253  90.916  7.058   1.00 32.06 ? 405  ARG A NH1   1 
ATOM   844  N NH2   . ARG A 1 112 ? 12.120  88.841  6.621   1.00 34.84 ? 405  ARG A NH2   1 
ATOM   845  N N     . ALA A 1 113 ? 6.040   93.080  1.026   1.00 30.54 ? 406  ALA A N     1 
ATOM   846  C CA    . ALA A 1 113 ? 4.891   93.930  0.740   1.00 28.14 ? 406  ALA A CA    1 
ATOM   847  C C     . ALA A 1 113 ? 3.953   93.271  -0.273  1.00 28.28 ? 406  ALA A C     1 
ATOM   848  O O     . ALA A 1 113 ? 2.749   93.209  -0.038  1.00 29.02 ? 406  ALA A O     1 
ATOM   849  C CB    . ALA A 1 113 ? 5.373   95.274  0.267   1.00 27.48 ? 406  ALA A CB    1 
ATOM   850  N N     . ALA A 1 114 ? 4.505   92.770  -1.390  1.00 29.09 ? 407  ALA A N     1 
ATOM   851  C CA    . ALA A 1 114 ? 3.734   92.086  -2.421  1.00 28.93 ? 407  ALA A CA    1 
ATOM   852  C C     . ALA A 1 114 ? 3.066   90.832  -1.861  1.00 28.82 ? 407  ALA A C     1 
ATOM   853  O O     . ALA A 1 114 ? 1.908   90.553  -2.180  1.00 30.19 ? 407  ALA A O     1 
ATOM   854  C CB    . ALA A 1 114 ? 4.603   91.730  -3.609  1.00 30.68 ? 407  ALA A CB    1 
ATOM   855  N N     . LEU A 1 115 ? 3.803   90.071  -1.045  1.00 29.80 ? 408  LEU A N     1 
ATOM   856  C CA    . LEU A 1 115 ? 3.275   88.862  -0.422  1.00 29.66 ? 408  LEU A CA    1 
ATOM   857  C C     . LEU A 1 115 ? 2.128   89.210  0.530   1.00 28.58 ? 408  LEU A C     1 
ATOM   858  O O     . LEU A 1 115 ? 1.123   88.503  0.576   1.00 30.40 ? 408  LEU A O     1 
ATOM   859  C CB    . LEU A 1 115 ? 4.405   88.155  0.331   1.00 30.23 ? 408  LEU A CB    1 
ATOM   860  C CG    . LEU A 1 115 ? 3.983   86.930  1.147   1.00 34.18 ? 408  LEU A CG    1 
ATOM   861  C CD1   . LEU A 1 115 ? 3.488   85.816  0.224   1.00 35.26 ? 408  LEU A CD1   1 
ATOM   862  C CD2   . LEU A 1 115 ? 5.126   86.433  2.032   1.00 34.26 ? 408  LEU A CD2   1 
ATOM   863  N N     . SER A 1 116 ? 2.283   90.297  1.294   1.00 26.71 ? 409  SER A N     1 
ATOM   864  C CA    . SER A 1 116 ? 1.245   90.727  2.224   1.00 28.58 ? 409  SER A CA    1 
ATOM   865  C C     . SER A 1 116 ? -0.062  90.957  1.466   1.00 29.92 ? 409  SER A C     1 
ATOM   866  O O     . SER A 1 116 ? -1.123  90.477  1.867   1.00 24.89 ? 409  SER A O     1 
ATOM   867  C CB    . SER A 1 116 ? 1.652   91.982  2.982   1.00 28.91 ? 409  SER A CB    1 
ATOM   868  O OG    . SER A 1 116 ? 2.720   91.734  3.881   1.00 28.83 ? 409  SER A OG    1 
ATOM   869  N N     . GLU A 1 117 ? 0.038   91.682  0.343   1.00 32.48 ? 410  GLU A N     1 
ATOM   870  C CA    . GLU A 1 117 ? -1.126  92.051  -0.452  1.00 33.97 ? 410  GLU A CA    1 
ATOM   871  C C     . GLU A 1 117 ? -1.781  90.792  -1.024  1.00 31.43 ? 410  GLU A C     1 
ATOM   872  O O     . GLU A 1 117 ? -3.001  90.634  -0.927  1.00 28.52 ? 410  GLU A O     1 
ATOM   873  C CB    . GLU A 1 117 ? -0.741  93.041  -1.559  1.00 33.32 ? 410  GLU A CB    1 
ATOM   874  C CG    . GLU A 1 117 ? -1.913  93.401  -2.454  1.00 35.80 ? 410  GLU A CG    1 
ATOM   875  C CD    . GLU A 1 117 ? -1.582  94.304  -3.633  1.00 38.01 ? 410  GLU A CD    1 
ATOM   876  O OE1   . GLU A 1 117 ? -0.541  94.082  -4.289  1.00 34.14 ? 410  GLU A OE1   1 
ATOM   877  O OE2   . GLU A 1 117 ? -2.374  95.217  -3.894  1.00 37.96 ? 410  GLU A OE2   1 
ATOM   878  N N     . ARG A 1 118 ? -0.971  89.885  -1.594  1.00 30.95 ? 411  ARG A N     1 
ATOM   879  C CA    . ARG A 1 118 ? -1.514  88.663  -2.177  1.00 33.86 ? 411  ARG A CA    1 
ATOM   880  C C     . ARG A 1 118 ? -2.131  87.757  -1.113  1.00 31.63 ? 411  ARG A C     1 
ATOM   881  O O     . ARG A 1 118 ? -3.190  87.182  -1.348  1.00 29.94 ? 411  ARG A O     1 
ATOM   882  C CB    . ARG A 1 118 ? -0.460  87.876  -2.965  1.00 41.09 ? 411  ARG A CB    1 
ATOM   883  C CG    . ARG A 1 118 ? 0.038   88.579  -4.225  1.00 49.34 ? 411  ARG A CG    1 
ATOM   884  C CD    . ARG A 1 118 ? 0.687   87.624  -5.215  1.00 54.79 ? 411  ARG A CD    1 
ATOM   885  N NE    . ARG A 1 118 ? 1.539   86.628  -4.563  1.00 61.72 ? 411  ARG A NE    1 
ATOM   886  C CZ    . ARG A 1 118 ? 2.788   86.829  -4.135  1.00 64.02 ? 411  ARG A CZ    1 
ATOM   887  N NH1   . ARG A 1 118 ? 3.367   85.920  -3.372  1.00 60.73 ? 411  ARG A NH1   1 
ATOM   888  N NH2   . ARG A 1 118 ? 3.463   87.917  -4.475  1.00 61.05 ? 411  ARG A NH2   1 
ATOM   889  N N     . LEU A 1 119 ? -1.450  87.558  0.029   1.00 31.59 ? 412  LEU A N     1 
ATOM   890  C CA    . LEU A 1 119 ? -1.969  86.646  1.045   1.00 29.94 ? 412  LEU A CA    1 
ATOM   891  C C     . LEU A 1 119 ? -3.268  87.216  1.617   1.00 28.55 ? 412  LEU A C     1 
ATOM   892  O O     . LEU A 1 119 ? -4.234  86.490  1.862   1.00 27.02 ? 412  LEU A O     1 
ATOM   893  C CB    . LEU A 1 119 ? -0.937  86.425  2.157   1.00 28.55 ? 412  LEU A CB    1 
ATOM   894  C CG    . LEU A 1 119 ? 0.163   85.400  1.884   1.00 30.84 ? 412  LEU A CG    1 
ATOM   895  C CD1   . LEU A 1 119 ? 1.192   85.426  3.012   1.00 30.25 ? 412  LEU A CD1   1 
ATOM   896  C CD2   . LEU A 1 119 ? -0.413  83.997  1.733   1.00 30.43 ? 412  LEU A CD2   1 
ATOM   897  N N     . PHE A 1 120 ? -3.306  88.531  1.831   1.00 27.51 ? 413  PHE A N     1 
ATOM   898  C CA    . PHE A 1 120 ? -4.538  89.125  2.330   1.00 29.74 ? 413  PHE A CA    1 
ATOM   899  C C     . PHE A 1 120 ? -5.742  88.730  1.460   1.00 30.33 ? 413  PHE A C     1 
ATOM   900  O O     . PHE A 1 120 ? -6.786  88.350  1.984   1.00 29.59 ? 413  PHE A O     1 
ATOM   901  C CB    . PHE A 1 120 ? -4.442  90.645  2.480   1.00 30.96 ? 413  PHE A CB    1 
ATOM   902  C CG    . PHE A 1 120 ? -5.658  91.177  3.191   1.00 33.36 ? 413  PHE A CG    1 
ATOM   903  C CD1   . PHE A 1 120 ? -5.833  90.948  4.548   1.00 37.27 ? 413  PHE A CD1   1 
ATOM   904  C CD2   . PHE A 1 120 ? -6.685  91.775  2.488   1.00 35.98 ? 413  PHE A CD2   1 
ATOM   905  C CE1   . PHE A 1 120 ? -6.986  91.364  5.197   1.00 40.57 ? 413  PHE A CE1   1 
ATOM   906  C CE2   . PHE A 1 120 ? -7.837  92.200  3.140   1.00 38.10 ? 413  PHE A CE2   1 
ATOM   907  C CZ    . PHE A 1 120 ? -7.988  91.991  4.489   1.00 37.18 ? 413  PHE A CZ    1 
ATOM   908  N N     . ALA A 1 121 ? -5.614  88.837  0.127   1.00 33.76 ? 414  ALA A N     1 
ATOM   909  C CA    . ALA A 1 121 ? -6.738  88.597  -0.766  1.00 33.43 ? 414  ALA A CA    1 
ATOM   910  C C     . ALA A 1 121 ? -7.065  87.107  -0.792  1.00 30.82 ? 414  ALA A C     1 
ATOM   911  O O     . ALA A 1 121 ? -8.232  86.729  -0.817  1.00 29.64 ? 414  ALA A O     1 
ATOM   912  C CB    . ALA A 1 121 ? -6.438  89.118  -2.152  1.00 36.46 ? 414  ALA A CB    1 
ATOM   913  N N     A ASN A 1 122 ? -6.024  86.268  -0.792  0.50 30.88 ? 415  ASN A N     1 
ATOM   914  N N     B ASN A 1 122 ? -6.006  86.290  -0.782  0.50 30.93 ? 415  ASN A N     1 
ATOM   915  C CA    A ASN A 1 122 ? -6.206  84.827  -0.744  0.50 30.03 ? 415  ASN A CA    1 
ATOM   916  C CA    B ASN A 1 122 ? -6.087  84.838  -0.726  0.50 30.22 ? 415  ASN A CA    1 
ATOM   917  C C     A ASN A 1 122 ? -6.974  84.452  0.522   0.50 28.36 ? 415  ASN A C     1 
ATOM   918  C C     B ASN A 1 122 ? -6.882  84.403  0.506   0.50 28.55 ? 415  ASN A C     1 
ATOM   919  O O     A ASN A 1 122 ? -8.014  83.799  0.448   0.50 29.98 ? 415  ASN A O     1 
ATOM   920  O O     B ASN A 1 122 ? -7.842  83.644  0.392   0.50 31.10 ? 415  ASN A O     1 
ATOM   921  C CB    A ASN A 1 122 ? -4.871  84.085  -0.834  0.50 30.04 ? 415  ASN A CB    1 
ATOM   922  C CB    B ASN A 1 122 ? -4.667  84.260  -0.768  0.50 30.04 ? 415  ASN A CB    1 
ATOM   923  C CG    A ASN A 1 122 ? -5.053  82.586  -0.760  0.50 30.94 ? 415  ASN A CG    1 
ATOM   924  C CG    B ASN A 1 122 ? -4.606  82.751  -0.707  0.50 30.97 ? 415  ASN A CG    1 
ATOM   925  O OD1   A ASN A 1 122 ? -5.169  82.018  0.327   0.50 28.85 ? 415  ASN A OD1   1 
ATOM   926  O OD1   B ASN A 1 122 ? -5.593  82.091  -0.379  0.50 32.84 ? 415  ASN A OD1   1 
ATOM   927  N ND2   A ASN A 1 122 ? -5.089  81.947  -1.918  0.50 31.30 ? 415  ASN A ND2   1 
ATOM   928  N ND2   B ASN A 1 122 ? -3.437  82.202  -1.001  0.50 29.79 ? 415  ASN A ND2   1 
ATOM   929  N N     . LEU A 1 123 ? -6.484  84.905  1.682   1.00 28.63 ? 416  LEU A N     1 
ATOM   930  C CA    . LEU A 1 123 ? -7.095  84.527  2.957   1.00 28.85 ? 416  LEU A CA    1 
ATOM   931  C C     . LEU A 1 123 ? -8.471  85.169  3.155   1.00 28.51 ? 416  LEU A C     1 
ATOM   932  O O     . LEU A 1 123 ? -9.391  84.503  3.628   1.00 27.27 ? 416  LEU A O     1 
ATOM   933  C CB    . LEU A 1 123 ? -6.135  84.867  4.099   1.00 28.76 ? 416  LEU A CB    1 
ATOM   934  C CG    . LEU A 1 123 ? -4.846  84.037  4.112   1.00 27.55 ? 416  LEU A CG    1 
ATOM   935  C CD1   . LEU A 1 123 ? -3.786  84.673  4.986   1.00 27.02 ? 416  LEU A CD1   1 
ATOM   936  C CD2   . LEU A 1 123 ? -5.108  82.621  4.567   1.00 27.94 ? 416  LEU A CD2   1 
ATOM   937  N N     . TRP A 1 124 ? -8.645  86.438  2.761   1.00 29.16 ? 417  TRP A N     1 
ATOM   938  C CA    . TRP A 1 124 ? -9.969  87.051  2.841   1.00 28.53 ? 417  TRP A CA    1 
ATOM   939  C C     . TRP A 1 124 ? -11.005 86.182  2.121   1.00 31.57 ? 417  TRP A C     1 
ATOM   940  O O     . TRP A 1 124 ? -12.095 85.912  2.639   1.00 32.07 ? 417  TRP A O     1 
ATOM   941  C CB    . TRP A 1 124 ? -9.932  88.456  2.254   1.00 30.12 ? 417  TRP A CB    1 
ATOM   942  C CG    . TRP A 1 124 ? -11.147 89.272  2.559   1.00 34.48 ? 417  TRP A CG    1 
ATOM   943  C CD1   . TRP A 1 124 ? -12.074 89.729  1.669   1.00 36.75 ? 417  TRP A CD1   1 
ATOM   944  C CD2   . TRP A 1 124 ? -11.542 89.778  3.846   1.00 35.21 ? 417  TRP A CD2   1 
ATOM   945  N NE1   . TRP A 1 124 ? -13.026 90.468  2.315   1.00 38.21 ? 417  TRP A NE1   1 
ATOM   946  C CE2   . TRP A 1 124 ? -12.728 90.519  3.650   1.00 37.70 ? 417  TRP A CE2   1 
ATOM   947  C CE3   . TRP A 1 124 ? -11.020 89.667  5.139   1.00 37.55 ? 417  TRP A CE3   1 
ATOM   948  C CZ2   . TRP A 1 124 ? -13.397 91.147  4.699   1.00 38.73 ? 417  TRP A CZ2   1 
ATOM   949  C CZ3   . TRP A 1 124 ? -11.676 90.296  6.177   1.00 38.03 ? 417  TRP A CZ3   1 
ATOM   950  C CH2   . TRP A 1 124 ? -12.854 91.017  5.958   1.00 39.21 ? 417  TRP A CH2   1 
ATOM   951  N N     . GLY A 1 125 ? -10.643 85.722  0.917   1.00 31.04 ? 418  GLY A N     1 
ATOM   952  C CA    . GLY A 1 125 ? -11.514 84.886  0.106   1.00 31.12 ? 418  GLY A CA    1 
ATOM   953  C C     . GLY A 1 125 ? -11.980 83.631  0.836   1.00 31.62 ? 418  GLY A C     1 
ATOM   954  O O     . GLY A 1 125 ? -13.134 83.235  0.712   1.00 33.61 ? 418  GLY A O     1 
ATOM   955  N N     . ARG A 1 126 ? -11.077 82.989  1.583   1.00 31.65 ? 419  ARG A N     1 
ATOM   956  C CA    . ARG A 1 126 ? -11.402 81.742  2.253   1.00 32.97 ? 419  ARG A CA    1 
ATOM   957  C C     . ARG A 1 126 ? -12.287 81.976  3.476   1.00 33.06 ? 419  ARG A C     1 
ATOM   958  O O     . ARG A 1 126 ? -12.829 81.026  4.012   1.00 31.12 ? 419  ARG A O     1 
ATOM   959  C CB    . ARG A 1 126 ? -10.124 81.012  2.673   1.00 33.63 ? 419  ARG A CB    1 
ATOM   960  C CG    . ARG A 1 126 ? -9.197  80.724  1.507   1.00 30.39 ? 419  ARG A CG    1 
ATOM   961  C CD    . ARG A 1 126 ? -8.027  79.873  1.906   1.00 31.67 ? 419  ARG A CD    1 
ATOM   962  N NE    . ARG A 1 126 ? -7.003  79.955  0.873   1.00 33.36 ? 419  ARG A NE    1 
ATOM   963  C CZ    . ARG A 1 126 ? -6.815  79.058  -0.090  1.00 36.56 ? 419  ARG A CZ    1 
ATOM   964  N NH1   . ARG A 1 126 ? -7.542  77.956  -0.140  1.00 36.39 ? 419  ARG A NH1   1 
ATOM   965  N NH2   . ARG A 1 126 ? -5.902  79.284  -1.018  1.00 38.95 ? 419  ARG A NH2   1 
ATOM   966  N N     . LEU A 1 127 ? -12.411 83.233  3.922   1.00 35.27 ? 420  LEU A N     1 
ATOM   967  C CA    . LEU A 1 127 ? -13.247 83.582  5.061   1.00 39.89 ? 420  LEU A CA    1 
ATOM   968  C C     . LEU A 1 127 ? -14.665 83.981  4.644   1.00 45.52 ? 420  LEU A C     1 
ATOM   969  O O     . LEU A 1 127 ? -15.440 84.425  5.489   1.00 44.63 ? 420  LEU A O     1 
ATOM   970  C CB    . LEU A 1 127 ? -12.569 84.731  5.812   1.00 39.72 ? 420  LEU A CB    1 
ATOM   971  C CG    . LEU A 1 127 ? -11.508 84.278  6.809   1.00 40.95 ? 420  LEU A CG    1 
ATOM   972  C CD1   . LEU A 1 127 ? -10.565 85.414  7.142   1.00 42.68 ? 420  LEU A CD1   1 
ATOM   973  C CD2   . LEU A 1 127 ? -12.164 83.727  8.069   1.00 40.63 ? 420  LEU A CD2   1 
ATOM   974  N N     . GLU A 1 128 ? -15.011 83.825  3.358   1.00 48.30 ? 421  GLU A N     1 
ATOM   975  C CA    . GLU A 1 128 ? -16.325 84.241  2.890   1.00 52.49 ? 421  GLU A CA    1 
ATOM   976  C C     . GLU A 1 128 ? -17.358 83.219  3.349   1.00 44.25 ? 421  GLU A C     1 
ATOM   977  O O     . GLU A 1 128 ? -17.203 82.021  3.135   1.00 43.02 ? 421  GLU A O     1 
ATOM   978  C CB    . GLU A 1 128 ? -16.333 84.493  1.376   1.00 60.11 ? 421  GLU A CB    1 
ATOM   979  C CG    . GLU A 1 128 ? -16.447 85.976  1.022   1.00 65.41 ? 421  GLU A CG    1 
ATOM   980  C CD    . GLU A 1 128 ? -15.577 86.474  -0.122  1.00 71.39 ? 421  GLU A CD    1 
ATOM   981  O OE1   . GLU A 1 128 ? -15.461 85.758  -1.142  1.00 72.74 ? 421  GLU A OE1   1 
ATOM   982  O OE2   . GLU A 1 128 ? -15.031 87.594  0.002   1.00 70.36 ? 421  GLU A OE2   1 
ATOM   983  N N     . GLY A 1 129 ? -18.386 83.720  4.038   1.00 45.89 ? 422  GLY A N     1 
ATOM   984  C CA    . GLY A 1 129 ? -19.408 82.866  4.623   1.00 46.16 ? 422  GLY A CA    1 
ATOM   985  C C     . GLY A 1 129 ? -19.055 82.387  6.034   1.00 45.13 ? 422  GLY A C     1 
ATOM   986  O O     . GLY A 1 129 ? -19.905 81.811  6.708   1.00 45.30 ? 422  GLY A O     1 
ATOM   987  N N     . GLU A 1 130 ? -17.806 82.616  6.474   1.00 39.26 ? 423  GLU A N     1 
ATOM   988  C CA    . GLU A 1 130 ? -17.385 82.269  7.824   1.00 39.25 ? 423  GLU A CA    1 
ATOM   989  C C     . GLU A 1 130 ? -17.711 83.440  8.751   1.00 37.60 ? 423  GLU A C     1 
ATOM   990  O O     . GLU A 1 130 ? -16.823 84.196  9.166   1.00 32.09 ? 423  GLU A O     1 
ATOM   991  C CB    . GLU A 1 130 ? -15.895 81.931  7.823   1.00 37.72 ? 423  GLU A CB    1 
ATOM   992  C CG    . GLU A 1 130 ? -15.577 80.625  7.130   1.00 39.57 ? 423  GLU A CG    1 
ATOM   993  C CD    . GLU A 1 130 ? -15.844 79.402  7.988   1.00 40.17 ? 423  GLU A CD    1 
ATOM   994  O OE1   . GLU A 1 130 ? -16.334 79.557  9.125   1.00 39.69 ? 423  GLU A OE1   1 
ATOM   995  O OE2   . GLU A 1 130 ? -15.531 78.302  7.531   1.00 42.34 ? 423  GLU A OE2   1 
ATOM   996  N N     . GLU A 1 131 ? -19.000 83.592  9.072   1.00 35.91 ? 424  GLU A N     1 
ATOM   997  C CA    . GLU A 1 131 ? -19.480 84.838  9.654   1.00 37.99 ? 424  GLU A CA    1 
ATOM   998  C C     . GLU A 1 131 ? -18.950 85.020  11.074  1.00 34.75 ? 424  GLU A C     1 
ATOM   999  O O     . GLU A 1 131 ? -18.709 86.154  11.495  1.00 30.36 ? 424  GLU A O     1 
ATOM   1000 C CB    . GLU A 1 131 ? -21.010 84.943  9.569   1.00 41.38 ? 424  GLU A CB    1 
ATOM   1001 C CG    . GLU A 1 131 ? -21.501 85.324  8.165   1.00 46.36 ? 424  GLU A CG    1 
ATOM   1002 C CD    . GLU A 1 131 ? -20.738 86.431  7.432   1.00 50.03 ? 424  GLU A CD    1 
ATOM   1003 O OE1   . GLU A 1 131 ? -20.348 86.211  6.260   1.00 51.09 ? 424  GLU A OE1   1 
ATOM   1004 O OE2   . GLU A 1 131 ? -20.525 87.520  8.024   1.00 49.59 ? 424  GLU A OE2   1 
ATOM   1005 N N     . ARG A 1 132 ? -18.724 83.914  11.800  1.00 34.91 ? 425  ARG A N     1 
ATOM   1006 C CA    . ARG A 1 132 ? -18.229 84.019  13.170  1.00 34.17 ? 425  ARG A CA    1 
ATOM   1007 C C     . ARG A 1 132 ? -16.734 84.365  13.204  1.00 30.17 ? 425  ARG A C     1 
ATOM   1008 O O     . ARG A 1 132 ? -16.318 85.217  13.995  1.00 27.02 ? 425  ARG A O     1 
ATOM   1009 C CB    . ARG A 1 132 ? -18.629 82.769  13.959  1.00 35.14 ? 425  ARG A CB    1 
ATOM   1010 C CG    . ARG A 1 132 ? -20.137 82.715  14.148  1.00 38.57 ? 425  ARG A CG    1 
ATOM   1011 C CD    . ARG A 1 132 ? -20.617 82.269  15.505  1.00 39.42 ? 425  ARG A CD    1 
ATOM   1012 N NE    . ARG A 1 132 ? -20.463 80.845  15.641  1.00 40.71 ? 425  ARG A NE    1 
ATOM   1013 C CZ    . ARG A 1 132 ? -20.204 80.227  16.781  1.00 43.50 ? 425  ARG A CZ    1 
ATOM   1014 N NH1   . ARG A 1 132 ? -20.362 80.866  17.925  1.00 47.06 ? 425  ARG A NH1   1 
ATOM   1015 N NH2   . ARG A 1 132 ? -19.805 78.968  16.766  1.00 45.30 ? 425  ARG A NH2   1 
ATOM   1016 N N     . LEU A 1 133 ? -15.937 83.744  12.328  1.00 29.70 ? 426  LEU A N     1 
ATOM   1017 C CA    . LEU A 1 133 ? -14.516 84.068  12.231  1.00 29.35 ? 426  LEU A CA    1 
ATOM   1018 C C     . LEU A 1 133 ? -14.331 85.521  11.806  1.00 29.04 ? 426  LEU A C     1 
ATOM   1019 O O     . LEU A 1 133 ? -13.427 86.203  12.284  1.00 26.25 ? 426  LEU A O     1 
ATOM   1020 C CB    . LEU A 1 133 ? -13.840 83.111  11.241  1.00 30.40 ? 426  LEU A CB    1 
ATOM   1021 C CG    . LEU A 1 133 ? -13.820 81.632  11.649  1.00 30.97 ? 426  LEU A CG    1 
ATOM   1022 C CD1   . LEU A 1 133 ? -12.899 80.833  10.747  1.00 30.55 ? 426  LEU A CD1   1 
ATOM   1023 C CD2   . LEU A 1 133 ? -13.428 81.451  13.105  1.00 31.26 ? 426  LEU A CD2   1 
ATOM   1024 N N     . LEU A 1 134 ? -15.205 86.008  10.914  1.00 31.92 ? 427  LEU A N     1 
ATOM   1025 C CA    . LEU A 1 134 ? -15.109 87.382  10.441  1.00 32.06 ? 427  LEU A CA    1 
ATOM   1026 C C     . LEU A 1 134 ? -15.441 88.361  11.560  1.00 29.30 ? 427  LEU A C     1 
ATOM   1027 O O     . LEU A 1 134 ? -14.820 89.420  11.663  1.00 28.94 ? 427  LEU A O     1 
ATOM   1028 C CB    . LEU A 1 134 ? -16.048 87.590  9.247   1.00 32.61 ? 427  LEU A CB    1 
ATOM   1029 C CG    . LEU A 1 134 ? -15.491 87.146  7.898   1.00 35.03 ? 427  LEU A CG    1 
ATOM   1030 C CD1   . LEU A 1 134 ? -16.591 87.169  6.836   1.00 38.44 ? 427  LEU A CD1   1 
ATOM   1031 C CD2   . LEU A 1 134 ? -14.335 88.034  7.477   1.00 35.20 ? 427  LEU A CD2   1 
ATOM   1032 N N     . TRP A 1 135 ? -16.429 87.994  12.381  1.00 28.96 ? 428  TRP A N     1 
ATOM   1033 C CA    . TRP A 1 135 ? -16.766 88.753  13.579  1.00 29.65 ? 428  TRP A CA    1 
ATOM   1034 C C     . TRP A 1 135 ? -15.565 88.831  14.524  1.00 27.99 ? 428  TRP A C     1 
ATOM   1035 O O     . TRP A 1 135 ? -15.224 89.893  15.051  1.00 25.00 ? 428  TRP A O     1 
ATOM   1036 C CB    . TRP A 1 135 ? -17.977 88.127  14.277  1.00 30.97 ? 428  TRP A CB    1 
ATOM   1037 C CG    . TRP A 1 135 ? -18.518 89.002  15.361  1.00 32.89 ? 428  TRP A CG    1 
ATOM   1038 C CD1   . TRP A 1 135 ? -19.451 89.992  15.222  1.00 34.16 ? 428  TRP A CD1   1 
ATOM   1039 C CD2   . TRP A 1 135 ? -18.065 89.057  16.725  1.00 33.42 ? 428  TRP A CD2   1 
ATOM   1040 N NE1   . TRP A 1 135 ? -19.649 90.618  16.421  1.00 35.92 ? 428  TRP A NE1   1 
ATOM   1041 C CE2   . TRP A 1 135 ? -18.814 90.070  17.362  1.00 33.76 ? 428  TRP A CE2   1 
ATOM   1042 C CE3   . TRP A 1 135 ? -17.133 88.330  17.478  1.00 32.78 ? 428  TRP A CE3   1 
ATOM   1043 C CZ2   . TRP A 1 135 ? -18.667 90.364  18.716  1.00 34.13 ? 428  TRP A CZ2   1 
ATOM   1044 C CZ3   . TRP A 1 135 ? -16.981 88.632  18.813  1.00 33.06 ? 428  TRP A CZ3   1 
ATOM   1045 C CH2   . TRP A 1 135 ? -17.740 89.631  19.424  1.00 35.02 ? 428  TRP A CH2   1 
ATOM   1046 N N     . LEU A 1 136 ? -14.902 87.686  14.726  1.00 28.91 ? 429  LEU A N     1 
ATOM   1047 C CA    . LEU A 1 136 ? -13.720 87.640  15.572  1.00 26.19 ? 429  LEU A CA    1 
ATOM   1048 C C     . LEU A 1 136 ? -12.617 88.525  14.994  1.00 25.44 ? 429  LEU A C     1 
ATOM   1049 O O     . LEU A 1 136 ? -11.980 89.267  15.731  1.00 25.22 ? 429  LEU A O     1 
ATOM   1050 C CB    . LEU A 1 136 ? -13.274 86.183  15.706  1.00 28.12 ? 429  LEU A CB    1 
ATOM   1051 C CG    . LEU A 1 136 ? -14.029 85.378  16.759  1.00 28.19 ? 429  LEU A CG    1 
ATOM   1052 C CD1   . LEU A 1 136 ? -13.749 83.893  16.613  1.00 29.78 ? 429  LEU A CD1   1 
ATOM   1053 C CD2   . LEU A 1 136 ? -13.680 85.863  18.156  1.00 29.05 ? 429  LEU A CD2   1 
ATOM   1054 N N     . TYR A 1 137 ? -12.408 88.467  13.677  1.00 25.67 ? 430  TYR A N     1 
ATOM   1055 C CA    . TYR A 1 137 ? -11.412 89.313  13.031  1.00 26.35 ? 430  TYR A CA    1 
ATOM   1056 C C     . TYR A 1 137 ? -11.746 90.792  13.223  1.00 27.21 ? 430  TYR A C     1 
ATOM   1057 O O     . TYR A 1 137 ? -10.890 91.581  13.633  1.00 26.55 ? 430  TYR A O     1 
ATOM   1058 C CB    . TYR A 1 137 ? -11.314 88.994  11.537  1.00 26.33 ? 430  TYR A CB    1 
ATOM   1059 C CG    . TYR A 1 137 ? -10.285 89.815  10.802  1.00 28.27 ? 430  TYR A CG    1 
ATOM   1060 C CD1   . TYR A 1 137 ? -8.931  89.588  11.000  1.00 29.73 ? 430  TYR A CD1   1 
ATOM   1061 C CD2   . TYR A 1 137 ? -10.649 90.848  9.945   1.00 28.65 ? 430  TYR A CD2   1 
ATOM   1062 C CE1   . TYR A 1 137 ? -7.967  90.342  10.347  1.00 30.84 ? 430  TYR A CE1   1 
ATOM   1063 C CE2   . TYR A 1 137 ? -9.694  91.624  9.294   1.00 27.04 ? 430  TYR A CE2   1 
ATOM   1064 C CZ    . TYR A 1 137 ? -8.348  91.366  9.491   1.00 30.66 ? 430  TYR A CZ    1 
ATOM   1065 O OH    . TYR A 1 137 ? -7.354  92.079  8.854   1.00 30.35 ? 430  TYR A OH    1 
ATOM   1066 N N     . ARG A 1 138 ? -12.990 91.173  12.895  1.00 28.18 ? 431  ARG A N     1 
ATOM   1067 C CA    . ARG A 1 138 ? -13.373 92.580  12.907  1.00 30.43 ? 431  ARG A CA    1 
ATOM   1068 C C     . ARG A 1 138 ? -13.513 93.138  14.320  1.00 29.32 ? 431  ARG A C     1 
ATOM   1069 O O     . ARG A 1 138 ? -13.135 94.284  14.569  1.00 28.34 ? 431  ARG A O     1 
ATOM   1070 C CB    . ARG A 1 138 ? -14.676 92.811  12.136  1.00 32.97 ? 431  ARG A CB    1 
ATOM   1071 C CG    . ARG A 1 138 ? -14.490 92.866  10.629  1.00 35.99 ? 431  ARG A CG    1 
ATOM   1072 C CD    . ARG A 1 138 ? -15.748 93.374  9.948   1.00 38.67 ? 431  ARG A CD    1 
ATOM   1073 N NE    . ARG A 1 138 ? -15.650 93.262  8.504   1.00 38.50 ? 431  ARG A NE    1 
ATOM   1074 C CZ    . ARG A 1 138 ? -16.319 92.375  7.779   1.00 40.29 ? 431  ARG A CZ    1 
ATOM   1075 N NH1   . ARG A 1 138 ? -16.218 92.379  6.461   1.00 37.00 ? 431  ARG A NH1   1 
ATOM   1076 N NH2   . ARG A 1 138 ? -17.078 91.482  8.387   1.00 41.56 ? 431  ARG A NH2   1 
ATOM   1077 N N     . GLU A 1 139 ? -14.084 92.358  15.236  1.00 30.64 ? 432  GLU A N     1 
ATOM   1078 C CA    . GLU A 1 139 ? -14.454 92.886  16.543  1.00 33.11 ? 432  GLU A CA    1 
ATOM   1079 C C     . GLU A 1 139 ? -13.417 92.572  17.626  1.00 30.99 ? 432  GLU A C     1 
ATOM   1080 O O     . GLU A 1 139 ? -13.425 93.205  18.685  1.00 29.10 ? 432  GLU A O     1 
ATOM   1081 C CB    . GLU A 1 139 ? -15.817 92.322  16.952  1.00 34.58 ? 432  GLU A CB    1 
ATOM   1082 C CG    . GLU A 1 139 ? -16.953 92.710  16.014  1.00 38.18 ? 432  GLU A CG    1 
ATOM   1083 C CD    . GLU A 1 139 ? -17.119 94.201  15.777  1.00 38.99 ? 432  GLU A CD    1 
ATOM   1084 O OE1   . GLU A 1 139 ? -16.888 94.968  16.710  1.00 42.13 ? 432  GLU A OE1   1 
ATOM   1085 O OE2   . GLU A 1 139 ? -17.491 94.586  14.655  1.00 47.14 ? 432  GLU A OE2   1 
ATOM   1086 N N     . VAL A 1 140 ? -12.523 91.603  17.378  1.00 29.39 ? 433  VAL A N     1 
ATOM   1087 C CA    . VAL A 1 140 ? -11.536 91.223  18.384  1.00 28.51 ? 433  VAL A CA    1 
ATOM   1088 C C     . VAL A 1 140 ? -10.108 91.394  17.853  1.00 26.29 ? 433  VAL A C     1 
ATOM   1089 O O     . VAL A 1 140 ? -9.392  92.279  18.319  1.00 23.76 ? 433  VAL A O     1 
ATOM   1090 C CB    . VAL A 1 140 ? -11.798 89.805  18.923  1.00 30.60 ? 433  VAL A CB    1 
ATOM   1091 C CG1   . VAL A 1 140 ? -10.721 89.374  19.906  1.00 33.05 ? 433  VAL A CG1   1 
ATOM   1092 C CG2   . VAL A 1 140 ? -13.177 89.708  19.573  1.00 30.70 ? 433  VAL A CG2   1 
ATOM   1093 N N     . GLU A 1 141 ? -9.677  90.560  16.897  1.00 26.54 ? 434  GLU A N     1 
ATOM   1094 C CA    . GLU A 1 141 ? -8.250  90.452  16.598  1.00 26.00 ? 434  GLU A CA    1 
ATOM   1095 C C     . GLU A 1 141 ? -7.696  91.737  15.975  1.00 25.74 ? 434  GLU A C     1 
ATOM   1096 O O     . GLU A 1 141 ? -6.635  92.220  16.371  1.00 26.17 ? 434  GLU A O     1 
ATOM   1097 C CB    . GLU A 1 141 ? -7.956  89.274  15.665  1.00 27.28 ? 434  GLU A CB    1 
ATOM   1098 C CG    . GLU A 1 141 ? -8.270  87.902  16.241  1.00 27.98 ? 434  GLU A CG    1 
ATOM   1099 C CD    . GLU A 1 141 ? -7.553  87.473  17.518  1.00 28.04 ? 434  GLU A CD    1 
ATOM   1100 O OE1   . GLU A 1 141 ? -6.697  88.237  18.058  1.00 27.80 ? 434  GLU A OE1   1 
ATOM   1101 O OE2   . GLU A 1 141 ? -7.874  86.380  18.000  1.00 28.84 ? 434  GLU A OE2   1 
ATOM   1102 N N     . ARG A 1 142 ? -8.385  92.291  14.972  1.00 27.70 ? 435  ARG A N     1 
ATOM   1103 C CA    . ARG A 1 142 ? -7.815  93.416  14.245  1.00 27.62 ? 435  ARG A CA    1 
ATOM   1104 C C     . ARG A 1 142 ? -7.690  94.602  15.196  1.00 26.45 ? 435  ARG A C     1 
ATOM   1105 O O     . ARG A 1 142 ? -6.631  95.235  15.273  1.00 25.62 ? 435  ARG A O     1 
ATOM   1106 C CB    . ARG A 1 142 ? -8.589  93.722  12.953  1.00 28.47 ? 435  ARG A CB    1 
ATOM   1107 C CG    . ARG A 1 142 ? -7.910  94.776  12.087  1.00 30.03 ? 435  ARG A CG    1 
ATOM   1108 C CD    . ARG A 1 142 ? -8.609  95.039  10.773  1.00 31.52 ? 435  ARG A CD    1 
ATOM   1109 N NE    . ARG A 1 142 ? -9.989  95.492  10.940  1.00 32.48 ? 435  ARG A NE    1 
ATOM   1110 C CZ    . ARG A 1 142 ? -10.909 95.461  9.983   1.00 31.53 ? 435  ARG A CZ    1 
ATOM   1111 N NH1   . ARG A 1 142 ? -10.555 95.222  8.729   1.00 30.91 ? 435  ARG A NH1   1 
ATOM   1112 N NH2   . ARG A 1 142 ? -12.179 95.682  10.286  1.00 31.30 ? 435  ARG A NH2   1 
ATOM   1113 N N     . PRO A 1 143 ? -8.746  94.976  15.952  1.00 28.27 ? 436  PRO A N     1 
ATOM   1114 C CA    . PRO A 1 143 ? -8.603  96.056  16.932  1.00 27.10 ? 436  PRO A CA    1 
ATOM   1115 C C     . PRO A 1 143 ? -7.646  95.718  18.078  1.00 25.96 ? 436  PRO A C     1 
ATOM   1116 O O     . PRO A 1 143 ? -6.927  96.595  18.551  1.00 24.27 ? 436  PRO A O     1 
ATOM   1117 C CB    . PRO A 1 143 ? -10.034 96.333  17.415  1.00 27.33 ? 436  PRO A CB    1 
ATOM   1118 C CG    . PRO A 1 143 ? -10.840 95.116  17.004  1.00 26.55 ? 436  PRO A CG    1 
ATOM   1119 C CD    . PRO A 1 143 ? -10.131 94.495  15.823  1.00 26.60 ? 436  PRO A CD    1 
ATOM   1120 N N     . LEU A 1 144 ? -7.579  94.445  18.501  1.00 25.15 ? 437  LEU A N     1 
ATOM   1121 C CA    . LEU A 1 144 ? -6.651  94.071  19.565  1.00 24.31 ? 437  LEU A CA    1 
ATOM   1122 C C     . LEU A 1 144 ? -5.210  94.385  19.158  1.00 24.81 ? 437  LEU A C     1 
ATOM   1123 O O     . LEU A 1 144 ? -4.395  94.785  19.982  1.00 26.08 ? 437  LEU A O     1 
ATOM   1124 C CB    . LEU A 1 144 ? -6.801  92.579  19.896  1.00 24.19 ? 437  LEU A CB    1 
ATOM   1125 C CG    . LEU A 1 144 ? -5.924  92.079  21.045  1.00 23.72 ? 437  LEU A CG    1 
ATOM   1126 C CD1   . LEU A 1 144 ? -6.348  92.702  22.375  1.00 24.66 ? 437  LEU A CD1   1 
ATOM   1127 C CD2   . LEU A 1 144 ? -5.970  90.565  21.151  1.00 23.02 ? 437  LEU A CD2   1 
ATOM   1128 N N     . SER A 1 145 ? -4.877  94.190  17.881  1.00 25.16 ? 438  SER A N     1 
ATOM   1129 C CA    . SER A 1 145 ? -3.519  94.400  17.419  1.00 24.64 ? 438  SER A CA    1 
ATOM   1130 C C     . SER A 1 145 ? -3.028  95.814  17.762  1.00 23.57 ? 438  SER A C     1 
ATOM   1131 O O     . SER A 1 145 ? -1.866  95.991  18.090  1.00 22.12 ? 438  SER A O     1 
ATOM   1132 C CB    . SER A 1 145 ? -3.404  94.042  15.951  1.00 23.98 ? 438  SER A CB    1 
ATOM   1133 O OG    . SER A 1 145 ? -4.067  94.983  15.130  1.00 28.33 ? 438  SER A OG    1 
ATOM   1134 N N     . ALA A 1 146 ? -3.924  96.813  17.746  1.00 24.98 ? 439  ALA A N     1 
ATOM   1135 C CA    . ALA A 1 146 ? -3.589  98.194  18.052  1.00 26.44 ? 439  ALA A CA    1 
ATOM   1136 C C     . ALA A 1 146 ? -3.358  98.348  19.548  1.00 26.23 ? 439  ALA A C     1 
ATOM   1137 O O     . ALA A 1 146 ? -2.473  99.087  19.986  1.00 29.18 ? 439  ALA A O     1 
ATOM   1138 C CB    . ALA A 1 146 ? -4.706  99.115  17.569  1.00 27.48 ? 439  ALA A CB    1 
ATOM   1139 N N     . VAL A 1 147 ? -4.161  97.630  20.338  1.00 25.07 ? 440  VAL A N     1 
ATOM   1140 C CA    . VAL A 1 147 ? -4.005  97.655  21.775  1.00 24.78 ? 440  VAL A CA    1 
ATOM   1141 C C     . VAL A 1 147 ? -2.636  97.069  22.110  1.00 24.48 ? 440  VAL A C     1 
ATOM   1142 O O     . VAL A 1 147 ? -1.883  97.629  22.904  1.00 24.80 ? 440  VAL A O     1 
ATOM   1143 C CB    . VAL A 1 147 ? -5.135  96.891  22.494  1.00 26.38 ? 440  VAL A CB    1 
ATOM   1144 C CG1   . VAL A 1 147 ? -4.961  96.945  24.010  1.00 25.20 ? 440  VAL A CG1   1 
ATOM   1145 C CG2   . VAL A 1 147 ? -6.518  97.397  22.096  1.00 27.07 ? 440  VAL A CG2   1 
ATOM   1146 N N     . LEU A 1 148 ? -2.302  95.940  21.479  1.00 24.00 ? 441  LEU A N     1 
ATOM   1147 C CA    . LEU A 1 148 ? -1.067  95.261  21.807  1.00 23.62 ? 441  LEU A CA    1 
ATOM   1148 C C     . LEU A 1 148 ? 0.109   96.174  21.466  1.00 25.16 ? 441  LEU A C     1 
ATOM   1149 O O     . LEU A 1 148 ? 1.094   96.190  22.192  1.00 26.31 ? 441  LEU A O     1 
ATOM   1150 C CB    . LEU A 1 148 ? -1.035  93.933  21.047  1.00 24.26 ? 441  LEU A CB    1 
ATOM   1151 C CG    . LEU A 1 148 ? -2.097  92.917  21.482  1.00 23.69 ? 441  LEU A CG    1 
ATOM   1152 C CD1   . LEU A 1 148 ? -1.937  91.612  20.724  1.00 24.00 ? 441  LEU A CD1   1 
ATOM   1153 C CD2   . LEU A 1 148 ? -2.042  92.675  22.980  1.00 23.12 ? 441  LEU A CD2   1 
ATOM   1154 N N     . ALA A 1 149 ? -0.006  96.943  20.369  1.00 27.36 ? 442  ALA A N     1 
ATOM   1155 C CA    . ALA A 1 149 ? 1.079   97.809  19.944  1.00 26.78 ? 442  ALA A CA    1 
ATOM   1156 C C     . ALA A 1 149 ? 1.367   98.875  21.004  1.00 27.17 ? 442  ALA A C     1 
ATOM   1157 O O     . ALA A 1 149 ? 2.531   99.115  21.325  1.00 26.75 ? 442  ALA A O     1 
ATOM   1158 C CB    . ALA A 1 149 ? 0.783   98.396  18.579  1.00 25.91 ? 442  ALA A CB    1 
ATOM   1159 N N     A HIS A 1 150 ? 0.315   99.491  21.550  0.50 28.10 ? 443  HIS A N     1 
ATOM   1160 N N     B HIS A 1 150 ? 0.315   99.532  21.529  0.50 28.61 ? 443  HIS A N     1 
ATOM   1161 C CA    A HIS A 1 150 ? 0.478   100.482 22.601  0.50 28.22 ? 443  HIS A CA    1 
ATOM   1162 C CA    B HIS A 1 150 ? 0.455   100.461 22.650  0.50 29.14 ? 443  HIS A CA    1 
ATOM   1163 C C     A HIS A 1 150 ? 1.052   99.850  23.877  0.50 27.40 ? 443  HIS A C     1 
ATOM   1164 C C     B HIS A 1 150 ? 1.169   99.781  23.812  0.50 27.68 ? 443  HIS A C     1 
ATOM   1165 O O     A HIS A 1 150 ? 1.857   100.476 24.552  0.50 29.64 ? 443  HIS A O     1 
ATOM   1166 O O     B HIS A 1 150 ? 2.157   100.295 24.322  0.50 28.62 ? 443  HIS A O     1 
ATOM   1167 C CB    A HIS A 1 150 ? -0.849  101.216 22.840  0.50 28.00 ? 443  HIS A CB    1 
ATOM   1168 C CB    B HIS A 1 150 ? -0.898  101.014 23.132  0.50 29.91 ? 443  HIS A CB    1 
ATOM   1169 C CG    A HIS A 1 150 ? -1.185  102.270 21.823  0.50 27.03 ? 443  HIS A CG    1 
ATOM   1170 C CG    B HIS A 1 150 ? -0.919  101.584 24.528  0.50 29.97 ? 443  HIS A CG    1 
ATOM   1171 N ND1   A HIS A 1 150 ? -0.505  103.456 21.699  0.50 25.77 ? 443  HIS A ND1   1 
ATOM   1172 N ND1   B HIS A 1 150 ? -0.787  102.926 24.816  0.50 30.39 ? 443  HIS A ND1   1 
ATOM   1173 C CD2   A HIS A 1 150 ? -2.178  102.293 20.886  0.50 27.20 ? 443  HIS A CD2   1 
ATOM   1174 C CD2   B HIS A 1 150 ? -1.076  100.950 25.734  0.50 30.81 ? 443  HIS A CD2   1 
ATOM   1175 C CE1   A HIS A 1 150 ? -1.046  104.175 20.718  0.50 24.73 ? 443  HIS A CE1   1 
ATOM   1176 C CE1   B HIS A 1 150 ? -0.860  103.113 26.133  0.50 29.14 ? 443  HIS A CE1   1 
ATOM   1177 N NE2   A HIS A 1 150 ? -2.077  103.471 20.195  0.50 26.62 ? 443  HIS A NE2   1 
ATOM   1178 N NE2   B HIS A 1 150 ? -1.045  101.894 26.728  0.50 28.15 ? 443  HIS A NE2   1 
ATOM   1179 N N     . MET A 1 151 ? 0.672   98.610  24.212  1.00 28.67 ? 444  MET A N     1 
ATOM   1180 C CA    . MET A 1 151 ? 1.222   97.925  25.383  1.00 27.95 ? 444  MET A CA    1 
ATOM   1181 C C     . MET A 1 151 ? 2.728   97.690  25.232  1.00 27.57 ? 444  MET A C     1 
ATOM   1182 O O     . MET A 1 151 ? 3.508   97.989  26.147  1.00 25.94 ? 444  MET A O     1 
ATOM   1183 C CB    . MET A 1 151 ? 0.512   96.586  25.622  1.00 27.34 ? 444  MET A CB    1 
ATOM   1184 C CG    . MET A 1 151 ? -0.919  96.767  26.048  1.00 26.00 ? 444  MET A CG    1 
ATOM   1185 S SD    . MET A 1 151 ? -1.910  95.244  25.998  1.00 28.64 ? 444  MET A SD    1 
ATOM   1186 C CE    . MET A 1 151 ? -1.228  94.361  27.396  1.00 24.74 ? 444  MET A CE    1 
ATOM   1187 N N     . GLU A 1 152 ? 3.147   97.174  24.066  1.00 28.26 ? 445  GLU A N     1 
ATOM   1188 C CA    . GLU A 1 152 ? 4.545   96.830  23.854  1.00 26.90 ? 445  GLU A CA    1 
ATOM   1189 C C     . GLU A 1 152 ? 5.418   98.082  23.856  1.00 26.01 ? 445  GLU A C     1 
ATOM   1190 O O     . GLU A 1 152 ? 6.520   98.050  24.391  1.00 25.32 ? 445  GLU A O     1 
ATOM   1191 C CB    . GLU A 1 152 ? 4.764   96.098  22.531  1.00 26.85 ? 445  GLU A CB    1 
ATOM   1192 C CG    . GLU A 1 152 ? 4.117   94.732  22.482  1.00 28.73 ? 445  GLU A CG    1 
ATOM   1193 C CD    . GLU A 1 152 ? 4.434   93.949  21.218  1.00 30.98 ? 445  GLU A CD    1 
ATOM   1194 O OE1   . GLU A 1 152 ? 5.446   94.279  20.542  1.00 31.48 ? 445  GLU A OE1   1 
ATOM   1195 O OE2   . GLU A 1 152 ? 3.662   93.011  20.910  1.00 29.87 ? 445  GLU A OE2   1 
ATOM   1196 N N     . ALA A 1 153 ? 4.926   99.164  23.250  1.00 27.13 ? 446  ALA A N     1 
ATOM   1197 C CA    . ALA A 1 153 ? 5.681   100.402 23.113  1.00 30.43 ? 446  ALA A CA    1 
ATOM   1198 C C     . ALA A 1 153 ? 5.742   101.160 24.443  1.00 31.90 ? 446  ALA A C     1 
ATOM   1199 O O     . ALA A 1 153 ? 6.696   101.899 24.701  1.00 33.91 ? 446  ALA A O     1 
ATOM   1200 C CB    . ALA A 1 153 ? 5.068   101.259 22.029  1.00 31.27 ? 446  ALA A CB    1 
ATOM   1201 N N     . THR A 1 154 ? 4.736   100.960 25.303  1.00 32.92 ? 447  THR A N     1 
ATOM   1202 C CA    . THR A 1 154 ? 4.707   101.623 26.598  1.00 31.44 ? 447  THR A CA    1 
ATOM   1203 C C     . THR A 1 154 ? 5.709   100.977 27.549  1.00 31.47 ? 447  THR A C     1 
ATOM   1204 O O     . THR A 1 154 ? 6.430   101.680 28.258  1.00 30.73 ? 447  THR A O     1 
ATOM   1205 C CB    . THR A 1 154 ? 3.291   101.649 27.180  1.00 33.01 ? 447  THR A CB    1 
ATOM   1206 O OG1   . THR A 1 154 ? 2.487   102.324 26.218  1.00 33.16 ? 447  THR A OG1   1 
ATOM   1207 C CG2   . THR A 1 154 ? 3.203   102.372 28.506  1.00 34.96 ? 447  THR A CG2   1 
ATOM   1208 N N     . GLY A 1 155 ? 5.760   99.638  27.557  1.00 28.80 ? 448  GLY A N     1 
ATOM   1209 C CA    . GLY A 1 155 ? 6.645   98.917  28.456  1.00 29.48 ? 448  GLY A CA    1 
ATOM   1210 C C     . GLY A 1 155 ? 6.231   99.096  29.918  1.00 30.21 ? 448  GLY A C     1 
ATOM   1211 O O     . GLY A 1 155 ? 5.205   99.701  30.216  1.00 30.04 ? 448  GLY A O     1 
ATOM   1212 N N     . VAL A 1 156 ? 7.030   98.544  30.830  1.00 31.81 ? 449  VAL A N     1 
ATOM   1213 C CA    . VAL A 1 156 ? 6.722   98.596  32.249  1.00 34.10 ? 449  VAL A CA    1 
ATOM   1214 C C     . VAL A 1 156 ? 7.991   99.026  32.978  1.00 35.92 ? 449  VAL A C     1 
ATOM   1215 O O     . VAL A 1 156 ? 9.100   98.677  32.561  1.00 36.81 ? 449  VAL A O     1 
ATOM   1216 C CB    . VAL A 1 156 ? 6.171   97.246  32.757  1.00 33.40 ? 449  VAL A CB    1 
ATOM   1217 C CG1   . VAL A 1 156 ? 7.209   96.137  32.688  1.00 31.58 ? 449  VAL A CG1   1 
ATOM   1218 C CG2   . VAL A 1 156 ? 5.611   97.368  34.160  1.00 36.11 ? 449  VAL A CG2   1 
ATOM   1219 N N     . ARG A 1 157 ? 7.813   99.823  34.041  1.00 38.98 ? 450  ARG A N     1 
ATOM   1220 C CA    . ARG A 1 157 ? 8.937   100.315 34.817  1.00 35.75 ? 450  ARG A CA    1 
ATOM   1221 C C     . ARG A 1 157 ? 9.386   99.244  35.814  1.00 36.41 ? 450  ARG A C     1 
ATOM   1222 O O     . ARG A 1 157 ? 8.564   98.556  36.436  1.00 35.96 ? 450  ARG A O     1 
ATOM   1223 C CB    . ARG A 1 157 ? 8.560   101.629 35.502  1.00 39.83 ? 450  ARG A CB    1 
ATOM   1224 C CG    . ARG A 1 157 ? 9.745   102.332 36.142  1.00 41.24 ? 450  ARG A CG    1 
ATOM   1225 C CD    . ARG A 1 157 ? 9.316   103.458 37.067  1.00 41.84 ? 450  ARG A CD    1 
ATOM   1226 N NE    . ARG A 1 157 ? 10.459  104.057 37.745  1.00 43.60 ? 450  ARG A NE    1 
ATOM   1227 C CZ    . ARG A 1 157 ? 10.368  104.922 38.752  1.00 46.59 ? 450  ARG A CZ    1 
ATOM   1228 N NH1   . ARG A 1 157 ? 9.188   105.296 39.217  1.00 42.48 ? 450  ARG A NH1   1 
ATOM   1229 N NH2   . ARG A 1 157 ? 11.469  105.420 39.284  1.00 50.43 ? 450  ARG A NH2   1 
ATOM   1230 N N     . LEU A 1 158 ? 10.714  99.133  35.950  1.00 34.67 ? 451  LEU A N     1 
ATOM   1231 C CA    . LEU A 1 158 ? 11.375  98.152  36.794  1.00 38.61 ? 451  LEU A CA    1 
ATOM   1232 C C     . LEU A 1 158 ? 12.233  98.877  37.842  1.00 44.39 ? 451  LEU A C     1 
ATOM   1233 O O     . LEU A 1 158 ? 12.793  99.937  37.552  1.00 40.98 ? 451  LEU A O     1 
ATOM   1234 C CB    . LEU A 1 158 ? 12.227  97.303  35.851  1.00 38.67 ? 451  LEU A CB    1 
ATOM   1235 C CG    . LEU A 1 158 ? 12.478  95.862  36.272  1.00 42.57 ? 451  LEU A CG    1 
ATOM   1236 C CD1   . LEU A 1 158 ? 11.172  95.066  36.287  1.00 42.78 ? 451  LEU A CD1   1 
ATOM   1237 C CD2   . LEU A 1 158 ? 13.514  95.216  35.358  1.00 40.96 ? 451  LEU A CD2   1 
ATOM   1238 N N     . ASP A 1 159 ? 12.309  98.322  39.065  1.00 45.36 ? 452  ASP A N     1 
ATOM   1239 C CA    . ASP A 1 159 ? 13.167  98.843  40.123  1.00 44.56 ? 452  ASP A CA    1 
ATOM   1240 C C     . ASP A 1 159 ? 14.520  98.140  40.057  1.00 44.11 ? 452  ASP A C     1 
ATOM   1241 O O     . ASP A 1 159 ? 14.708  97.086  40.667  1.00 44.29 ? 452  ASP A O     1 
ATOM   1242 C CB    . ASP A 1 159 ? 12.546  98.640  41.510  1.00 48.27 ? 452  ASP A CB    1 
ATOM   1243 C CG    . ASP A 1 159 ? 13.255  99.389  42.633  1.00 49.44 ? 452  ASP A CG    1 
ATOM   1244 O OD1   . ASP A 1 159 ? 14.496  99.553  42.560  1.00 45.83 ? 452  ASP A OD1   1 
ATOM   1245 O OD2   . ASP A 1 159 ? 12.565  99.768  43.593  1.00 51.68 ? 452  ASP A OD2   1 
ATOM   1246 N N     . VAL A 1 160 ? 15.465  98.746  39.326  1.00 41.24 ? 453  VAL A N     1 
ATOM   1247 C CA    . VAL A 1 160 ? 16.702  98.074  38.959  1.00 43.10 ? 453  VAL A CA    1 
ATOM   1248 C C     . VAL A 1 160 ? 17.585  97.868  40.191  1.00 41.35 ? 453  VAL A C     1 
ATOM   1249 O O     . VAL A 1 160 ? 18.248  96.834  40.314  1.00 39.58 ? 453  VAL A O     1 
ATOM   1250 C CB    . VAL A 1 160 ? 17.443  98.845  37.848  1.00 41.18 ? 453  VAL A CB    1 
ATOM   1251 C CG1   . VAL A 1 160 ? 18.889  98.401  37.709  1.00 42.05 ? 453  VAL A CG1   1 
ATOM   1252 C CG2   . VAL A 1 160 ? 16.719  98.712  36.515  1.00 42.82 ? 453  VAL A CG2   1 
ATOM   1253 N N     . ALA A 1 161 ? 17.623  98.878  41.068  1.00 44.76 ? 454  ALA A N     1 
ATOM   1254 C CA    . ALA A 1 161 ? 18.472  98.851  42.254  1.00 43.42 ? 454  ALA A CA    1 
ATOM   1255 C C     . ALA A 1 161 ? 17.998  97.752  43.215  1.00 42.93 ? 454  ALA A C     1 
ATOM   1256 O O     . ALA A 1 161 ? 18.804  96.960  43.706  1.00 44.51 ? 454  ALA A O     1 
ATOM   1257 C CB    . ALA A 1 161 ? 18.464  100.220 42.900  1.00 44.10 ? 454  ALA A CB    1 
ATOM   1258 N N     . TYR A 1 162 ? 16.680  97.693  43.450  1.00 41.31 ? 455  TYR A N     1 
ATOM   1259 C CA    . TYR A 1 162 ? 16.062  96.608  44.209  1.00 41.82 ? 455  TYR A CA    1 
ATOM   1260 C C     . TYR A 1 162 ? 16.534  95.246  43.695  1.00 41.16 ? 455  TYR A C     1 
ATOM   1261 O O     . TYR A 1 162 ? 16.911  94.392  44.488  1.00 41.64 ? 455  TYR A O     1 
ATOM   1262 C CB    . TYR A 1 162 ? 14.542  96.788  44.190  1.00 42.89 ? 455  TYR A CB    1 
ATOM   1263 C CG    . TYR A 1 162 ? 13.730  95.676  44.813  1.00 45.75 ? 455  TYR A CG    1 
ATOM   1264 C CD1   . TYR A 1 162 ? 13.381  94.555  44.074  1.00 43.37 ? 455  TYR A CD1   1 
ATOM   1265 C CD2   . TYR A 1 162 ? 13.285  95.749  46.128  1.00 41.64 ? 455  TYR A CD2   1 
ATOM   1266 C CE1   . TYR A 1 162 ? 12.620  93.534  44.622  1.00 44.73 ? 455  TYR A CE1   1 
ATOM   1267 C CE2   . TYR A 1 162 ? 12.523  94.735  46.695  1.00 42.78 ? 455  TYR A CE2   1 
ATOM   1268 C CZ    . TYR A 1 162 ? 12.194  93.618  45.938  1.00 45.17 ? 455  TYR A CZ    1 
ATOM   1269 O OH    . TYR A 1 162 ? 11.434  92.590  46.453  1.00 41.64 ? 455  TYR A OH    1 
ATOM   1270 N N     . LEU A 1 163 ? 16.568  95.064  42.367  1.00 42.08 ? 456  LEU A N     1 
ATOM   1271 C CA    . LEU A 1 163 ? 16.906  93.785  41.752  1.00 42.10 ? 456  LEU A CA    1 
ATOM   1272 C C     . LEU A 1 163 ? 18.412  93.519  41.780  1.00 43.25 ? 456  LEU A C     1 
ATOM   1273 O O     . LEU A 1 163 ? 18.838  92.364  41.861  1.00 36.52 ? 456  LEU A O     1 
ATOM   1274 C CB    . LEU A 1 163 ? 16.381  93.770  40.308  1.00 42.38 ? 456  LEU A CB    1 
ATOM   1275 C CG    . LEU A 1 163 ? 14.911  93.366  40.140  1.00 45.20 ? 456  LEU A CG    1 
ATOM   1276 C CD1   . LEU A 1 163 ? 14.437  93.599  38.708  1.00 46.23 ? 456  LEU A CD1   1 
ATOM   1277 C CD2   . LEU A 1 163 ? 14.697  91.910  40.534  1.00 43.63 ? 456  LEU A CD2   1 
ATOM   1278 N N     . ARG A 1 164 ? 19.217  94.582  41.619  1.00 44.74 ? 457  ARG A N     1 
ATOM   1279 C CA    . ARG A 1 164 ? 20.658  94.487  41.809  1.00 46.23 ? 457  ARG A CA    1 
ATOM   1280 C C     . ARG A 1 164 ? 20.938  93.945  43.212  1.00 40.81 ? 457  ARG A C     1 
ATOM   1281 O O     . ARG A 1 164 ? 21.661  92.965  43.362  1.00 46.36 ? 457  ARG A O     1 
ATOM   1282 C CB    . ARG A 1 164 ? 21.329  95.848  41.559  1.00 46.78 ? 457  ARG A CB    1 
ATOM   1283 C CG    . ARG A 1 164 ? 22.059  95.964  40.228  1.00 48.99 ? 457  ARG A CG    1 
ATOM   1284 C CD    . ARG A 1 164 ? 21.266  95.525  39.013  1.00 53.99 ? 457  ARG A CD    1 
ATOM   1285 N NE    . ARG A 1 164 ? 21.754  96.101  37.761  1.00 52.65 ? 457  ARG A NE    1 
ATOM   1286 C CZ    . ARG A 1 164 ? 22.057  95.409  36.664  1.00 52.53 ? 457  ARG A CZ    1 
ATOM   1287 N NH1   . ARG A 1 164 ? 22.159  96.023  35.497  1.00 51.26 ? 457  ARG A NH1   1 
ATOM   1288 N NH2   . ARG A 1 164 ? 22.235  94.101  36.727  1.00 51.45 ? 457  ARG A NH2   1 
ATOM   1289 N N     . ALA A 1 165 ? 20.318  94.565  44.219  1.00 42.99 ? 458  ALA A N     1 
ATOM   1290 C CA    . ALA A 1 165 ? 20.419  94.129  45.608  1.00 44.62 ? 458  ALA A CA    1 
ATOM   1291 C C     . ALA A 1 165 ? 19.917  92.692  45.789  1.00 47.22 ? 458  ALA A C     1 
ATOM   1292 O O     . ALA A 1 165 ? 20.601  91.863  46.385  1.00 47.54 ? 458  ALA A O     1 
ATOM   1293 C CB    . ALA A 1 165 ? 19.642  95.079  46.487  1.00 43.65 ? 458  ALA A CB    1 
ATOM   1294 N N     . LEU A 1 166 ? 18.710  92.396  45.286  1.00 46.21 ? 459  LEU A N     1 
ATOM   1295 C CA    . LEU A 1 166 ? 18.133  91.068  45.443  1.00 45.09 ? 459  LEU A CA    1 
ATOM   1296 C C     . LEU A 1 166 ? 19.081  90.013  44.875  1.00 41.29 ? 459  LEU A C     1 
ATOM   1297 O O     . LEU A 1 166 ? 19.199  88.920  45.423  1.00 42.68 ? 459  LEU A O     1 
ATOM   1298 C CB    . LEU A 1 166 ? 16.764  91.031  44.753  1.00 45.89 ? 459  LEU A CB    1 
ATOM   1299 C CG    . LEU A 1 166 ? 15.915  89.782  45.007  1.00 45.85 ? 459  LEU A CG    1 
ATOM   1300 C CD1   . LEU A 1 166 ? 15.489  89.689  46.465  1.00 46.55 ? 459  LEU A CD1   1 
ATOM   1301 C CD2   . LEU A 1 166 ? 14.686  89.779  44.110  1.00 44.78 ? 459  LEU A CD2   1 
ATOM   1302 N N     . SER A 1 167 ? 19.775  90.351  43.780  1.00 42.17 ? 460  SER A N     1 
ATOM   1303 C CA    . SER A 1 167 ? 20.701  89.435  43.133  1.00 43.65 ? 460  SER A CA    1 
ATOM   1304 C C     . SER A 1 167 ? 21.852  89.030  44.058  1.00 49.10 ? 460  SER A C     1 
ATOM   1305 O O     . SER A 1 167 ? 22.245  87.860  44.092  1.00 43.86 ? 460  SER A O     1 
ATOM   1306 C CB    . SER A 1 167 ? 21.235  90.043  41.866  1.00 44.36 ? 460  SER A CB    1 
ATOM   1307 O OG    . SER A 1 167 ? 21.879  89.054  41.084  1.00 43.91 ? 460  SER A OG    1 
ATOM   1308 N N     . LEU A 1 168 ? 22.429  90.030  44.747  1.00 57.03 ? 461  LEU A N     1 
ATOM   1309 C CA    . LEU A 1 168 ? 23.520  89.831  45.695  1.00 55.04 ? 461  LEU A CA    1 
ATOM   1310 C C     . LEU A 1 168 ? 23.068  88.895  46.812  1.00 49.00 ? 461  LEU A C     1 
ATOM   1311 O O     . LEU A 1 168 ? 23.716  87.895  47.102  1.00 54.45 ? 461  LEU A O     1 
ATOM   1312 C CB    . LEU A 1 168 ? 23.919  91.188  46.287  1.00 57.73 ? 461  LEU A CB    1 
ATOM   1313 C CG    . LEU A 1 168 ? 24.614  92.161  45.337  1.00 60.36 ? 461  LEU A CG    1 
ATOM   1314 C CD1   . LEU A 1 168 ? 24.872  93.493  46.035  1.00 60.96 ? 461  LEU A CD1   1 
ATOM   1315 C CD2   . LEU A 1 168 ? 25.910  91.567  44.802  1.00 57.61 ? 461  LEU A CD2   1 
ATOM   1316 N N     . GLU A 1 169 ? 21.943  89.247  47.429  1.00 48.30 ? 462  GLU A N     1 
ATOM   1317 C CA    . GLU A 1 169 ? 21.372  88.470  48.514  1.00 49.55 ? 462  GLU A CA    1 
ATOM   1318 C C     . GLU A 1 169 ? 21.244  87.002  48.097  1.00 49.79 ? 462  GLU A C     1 
ATOM   1319 O O     . GLU A 1 169 ? 21.725  86.106  48.785  1.00 48.82 ? 462  GLU A O     1 
ATOM   1320 C CB    . GLU A 1 169 ? 20.047  89.117  48.911  1.00 48.14 ? 462  GLU A CB    1 
ATOM   1321 C CG    . GLU A 1 169 ? 19.284  88.358  49.976  1.00 49.78 ? 462  GLU A CG    1 
ATOM   1322 C CD    . GLU A 1 169 ? 17.927  88.951  50.295  1.00 50.80 ? 462  GLU A CD    1 
ATOM   1323 O OE1   . GLU A 1 169 ? 17.631  90.071  49.814  1.00 55.91 ? 462  GLU A OE1   1 
ATOM   1324 O OE2   . GLU A 1 169 ? 17.164  88.290  51.016  1.00 55.51 ? 462  GLU A OE2   1 
ATOM   1325 N N     . VAL A 1 170 ? 20.622  86.752  46.942  1.00 48.36 ? 463  VAL A N     1 
ATOM   1326 C CA    . VAL A 1 170 ? 20.352  85.388  46.511  1.00 43.29 ? 463  VAL A CA    1 
ATOM   1327 C C     . VAL A 1 170 ? 21.660  84.699  46.129  1.00 43.23 ? 463  VAL A C     1 
ATOM   1328 O O     . VAL A 1 170 ? 21.797  83.494  46.332  1.00 40.51 ? 463  VAL A O     1 
ATOM   1329 C CB    . VAL A 1 170 ? 19.341  85.360  45.346  1.00 45.32 ? 463  VAL A CB    1 
ATOM   1330 C CG1   . VAL A 1 170 ? 19.145  83.953  44.801  1.00 43.94 ? 463  VAL A CG1   1 
ATOM   1331 C CG2   . VAL A 1 170 ? 18.004  85.983  45.733  1.00 44.01 ? 463  VAL A CG2   1 
ATOM   1332 N N     . ALA A 1 171 ? 22.608  85.449  45.546  1.00 46.19 ? 464  ALA A N     1 
ATOM   1333 C CA    . ALA A 1 171 ? 23.919  84.901  45.221  1.00 48.64 ? 464  ALA A CA    1 
ATOM   1334 C C     . ALA A 1 171 ? 24.539  84.244  46.456  1.00 49.79 ? 464  ALA A C     1 
ATOM   1335 O O     . ALA A 1 171 ? 25.073  83.137  46.369  1.00 45.20 ? 464  ALA A O     1 
ATOM   1336 C CB    . ALA A 1 171 ? 24.820  85.984  44.675  1.00 49.58 ? 464  ALA A CB    1 
ATOM   1337 N N     . GLU A 1 172 ? 24.438  84.934  47.603  1.00 55.16 ? 465  GLU A N     1 
ATOM   1338 C CA    . GLU A 1 172 ? 25.030  84.473  48.854  1.00 58.12 ? 465  GLU A CA    1 
ATOM   1339 C C     . GLU A 1 172 ? 24.412  83.138  49.267  1.00 56.14 ? 465  GLU A C     1 
ATOM   1340 O O     . GLU A 1 172 ? 25.138  82.199  49.582  1.00 55.61 ? 465  GLU A O     1 
ATOM   1341 C CB    . GLU A 1 172 ? 24.869  85.521  49.959  1.00 63.37 ? 465  GLU A CB    1 
ATOM   1342 C CG    . GLU A 1 172 ? 25.789  86.725  49.784  1.00 67.86 ? 465  GLU A CG    1 
ATOM   1343 C CD    . GLU A 1 172 ? 25.733  87.790  50.870  1.00 72.68 ? 465  GLU A CD    1 
ATOM   1344 O OE1   . GLU A 1 172 ? 26.588  88.700  50.837  1.00 75.02 ? 465  GLU A OE1   1 
ATOM   1345 O OE2   . GLU A 1 172 ? 24.836  87.723  51.739  1.00 76.29 ? 465  GLU A OE2   1 
ATOM   1346 N N     . GLU A 1 173 ? 23.075  83.055  49.240  1.00 53.13 ? 466  GLU A N     1 
ATOM   1347 C CA    . GLU A 1 173 ? 22.374  81.842  49.635  1.00 52.18 ? 466  GLU A CA    1 
ATOM   1348 C C     . GLU A 1 173 ? 22.743  80.673  48.715  1.00 47.84 ? 466  GLU A C     1 
ATOM   1349 O O     . GLU A 1 173 ? 22.859  79.538  49.174  1.00 49.45 ? 466  GLU A O     1 
ATOM   1350 C CB    . GLU A 1 173 ? 20.867  82.095  49.636  1.00 56.45 ? 466  GLU A CB    1 
ATOM   1351 C CG    . GLU A 1 173 ? 20.051  80.911  50.128  1.00 64.15 ? 466  GLU A CG    1 
ATOM   1352 C CD    . GLU A 1 173 ? 20.118  80.658  51.624  1.00 72.92 ? 466  GLU A CD    1 
ATOM   1353 O OE1   . GLU A 1 173 ? 20.551  81.578  52.359  1.00 77.20 ? 466  GLU A OE1   1 
ATOM   1354 O OE2   . GLU A 1 173 ? 19.746  79.540  52.052  1.00 71.12 ? 466  GLU A OE2   1 
ATOM   1355 N N     . ILE A 1 174 ? 22.906  80.947  47.412  1.00 44.54 ? 467  ILE A N     1 
ATOM   1356 C CA    . ILE A 1 174 ? 23.256  79.914  46.443  1.00 44.64 ? 467  ILE A CA    1 
ATOM   1357 C C     . ILE A 1 174 ? 24.609  79.305  46.799  1.00 45.32 ? 467  ILE A C     1 
ATOM   1358 O O     . ILE A 1 174 ? 24.774  78.087  46.736  1.00 44.34 ? 467  ILE A O     1 
ATOM   1359 C CB    . ILE A 1 174 ? 23.251  80.470  44.999  1.00 44.52 ? 467  ILE A CB    1 
ATOM   1360 C CG1   . ILE A 1 174 ? 21.829  80.762  44.512  1.00 46.62 ? 467  ILE A CG1   1 
ATOM   1361 C CG2   . ILE A 1 174 ? 23.977  79.527  44.044  1.00 45.35 ? 467  ILE A CG2   1 
ATOM   1362 C CD1   . ILE A 1 174 ? 21.761  81.633  43.279  1.00 48.69 ? 467  ILE A CD1   1 
ATOM   1363 N N     . ALA A 1 175 ? 25.581  80.174  47.118  1.00 46.79 ? 468  ALA A N     1 
ATOM   1364 C CA    . ALA A 1 175 ? 26.933  79.744  47.444  1.00 50.29 ? 468  ALA A CA    1 
ATOM   1365 C C     . ALA A 1 175 ? 26.929  78.868  48.695  1.00 49.24 ? 468  ALA A C     1 
ATOM   1366 O O     . ALA A 1 175 ? 27.688  77.905  48.763  1.00 56.82 ? 468  ALA A O     1 
ATOM   1367 C CB    . ALA A 1 175 ? 27.826  80.946  47.618  1.00 48.39 ? 468  ALA A CB    1 
ATOM   1368 N N     . ARG A 1 176 ? 26.078  79.213  49.673  1.00 53.11 ? 469  ARG A N     1 
ATOM   1369 C CA    . ARG A 1 176 ? 25.937  78.429  50.893  1.00 57.14 ? 469  ARG A CA    1 
ATOM   1370 C C     . ARG A 1 176 ? 25.460  77.022  50.557  1.00 52.63 ? 469  ARG A C     1 
ATOM   1371 O O     . ARG A 1 176 ? 26.062  76.046  50.992  1.00 53.17 ? 469  ARG A O     1 
ATOM   1372 C CB    . ARG A 1 176 ? 24.908  79.033  51.852  1.00 61.46 ? 469  ARG A CB    1 
ATOM   1373 C CG    . ARG A 1 176 ? 25.346  80.291  52.589  1.00 67.73 ? 469  ARG A CG    1 
ATOM   1374 C CD    . ARG A 1 176 ? 24.252  80.719  53.556  1.00 70.68 ? 469  ARG A CD    1 
ATOM   1375 N NE    . ARG A 1 176 ? 23.700  79.540  54.214  1.00 78.97 ? 469  ARG A NE    1 
ATOM   1376 C CZ    . ARG A 1 176 ? 22.438  79.128  54.122  1.00 87.46 ? 469  ARG A CZ    1 
ATOM   1377 N NH1   . ARG A 1 176 ? 21.451  80.004  54.152  1.00 95.20 ? 469  ARG A NH1   1 
ATOM   1378 N NH2   . ARG A 1 176 ? 22.164  77.835  54.059  1.00 89.31 ? 469  ARG A NH2   1 
ATOM   1379 N N     . LEU A 1 177 ? 24.366  76.940  49.787  1.00 52.87 ? 470  LEU A N     1 
ATOM   1380 C CA    . LEU A 1 177 ? 23.738  75.669  49.449  1.00 50.45 ? 470  LEU A CA    1 
ATOM   1381 C C     . LEU A 1 177 ? 24.698  74.798  48.649  1.00 51.07 ? 470  LEU A C     1 
ATOM   1382 O O     . LEU A 1 177 ? 24.744  73.580  48.825  1.00 50.51 ? 470  LEU A O     1 
ATOM   1383 C CB    . LEU A 1 177 ? 22.459  75.946  48.655  1.00 51.86 ? 470  LEU A CB    1 
ATOM   1384 C CG    . LEU A 1 177 ? 21.264  76.395  49.492  1.00 52.29 ? 470  LEU A CG    1 
ATOM   1385 C CD1   . LEU A 1 177 ? 20.200  77.061  48.628  1.00 52.90 ? 470  LEU A CD1   1 
ATOM   1386 C CD2   . LEU A 1 177 ? 20.675  75.215  50.242  1.00 49.47 ? 470  LEU A CD2   1 
ATOM   1387 N N     . GLU A 1 178 ? 25.455  75.447  47.764  1.00 50.16 ? 471  GLU A N     1 
ATOM   1388 C CA    . GLU A 1 178 ? 26.411  74.760  46.918  1.00 54.11 ? 471  GLU A CA    1 
ATOM   1389 C C     . GLU A 1 178 ? 27.453  74.065  47.792  1.00 55.95 ? 471  GLU A C     1 
ATOM   1390 O O     . GLU A 1 178 ? 27.755  72.889  47.594  1.00 52.94 ? 471  GLU A O     1 
ATOM   1391 C CB    . GLU A 1 178 ? 27.059  75.771  45.976  1.00 53.03 ? 471  GLU A CB    1 
ATOM   1392 C CG    . GLU A 1 178 ? 27.614  75.146  44.723  1.00 56.83 ? 471  GLU A CG    1 
ATOM   1393 C CD    . GLU A 1 178 ? 28.299  76.134  43.798  1.00 57.79 ? 471  GLU A CD    1 
ATOM   1394 O OE1   . GLU A 1 178 ? 28.637  77.244  44.264  1.00 58.01 ? 471  GLU A OE1   1 
ATOM   1395 O OE2   . GLU A 1 178 ? 28.478  75.795  42.613  1.00 59.56 ? 471  GLU A OE2   1 
ATOM   1396 N N     . ALA A 1 179 ? 27.987  74.818  48.763  1.00 56.42 ? 472  ALA A N     1 
ATOM   1397 C CA    . ALA A 1 179 ? 28.985  74.307  49.691  1.00 59.02 ? 472  ALA A CA    1 
ATOM   1398 C C     . ALA A 1 179 ? 28.407  73.181  50.553  1.00 55.70 ? 472  ALA A C     1 
ATOM   1399 O O     . ALA A 1 179 ? 29.076  72.179  50.769  1.00 63.53 ? 472  ALA A O     1 
ATOM   1400 C CB    . ALA A 1 179 ? 29.514  75.441  50.533  1.00 56.51 ? 472  ALA A CB    1 
ATOM   1401 N N     . GLU A 1 180 ? 27.165  73.336  51.029  1.00 57.12 ? 473  GLU A N     1 
ATOM   1402 C CA    . GLU A 1 180 ? 26.522  72.320  51.857  1.00 59.71 ? 473  GLU A CA    1 
ATOM   1403 C C     . GLU A 1 180 ? 26.253  71.050  51.053  1.00 59.89 ? 473  GLU A C     1 
ATOM   1404 O O     . GLU A 1 180 ? 26.242  69.958  51.616  1.00 61.00 ? 473  GLU A O     1 
ATOM   1405 C CB    . GLU A 1 180 ? 25.217  72.839  52.462  1.00 60.75 ? 473  GLU A CB    1 
ATOM   1406 C CG    . GLU A 1 180 ? 25.431  73.992  53.430  1.00 70.17 ? 473  GLU A CG    1 
ATOM   1407 C CD    . GLU A 1 180 ? 24.183  74.506  54.130  1.00 74.00 ? 473  GLU A CD    1 
ATOM   1408 O OE1   . GLU A 1 180 ? 23.668  73.794  55.018  1.00 77.03 ? 473  GLU A OE1   1 
ATOM   1409 O OE2   . GLU A 1 180 ? 23.729  75.618  53.783  1.00 80.81 ? 473  GLU A OE2   1 
ATOM   1410 N N     . VAL A 1 181 ? 26.024  71.197  49.740  1.00 59.85 ? 474  VAL A N     1 
ATOM   1411 C CA    . VAL A 1 181 ? 25.718  70.059  48.888  1.00 56.16 ? 474  VAL A CA    1 
ATOM   1412 C C     . VAL A 1 181 ? 27.008  69.305  48.582  1.00 55.56 ? 474  VAL A C     1 
ATOM   1413 O O     . VAL A 1 181 ? 27.019  68.077  48.618  1.00 51.34 ? 474  VAL A O     1 
ATOM   1414 C CB    . VAL A 1 181 ? 24.997  70.487  47.593  1.00 54.13 ? 474  VAL A CB    1 
ATOM   1415 C CG1   . VAL A 1 181 ? 24.928  69.351  46.582  1.00 50.84 ? 474  VAL A CG1   1 
ATOM   1416 C CG2   . VAL A 1 181 ? 23.608  71.034  47.884  1.00 51.63 ? 474  VAL A CG2   1 
ATOM   1417 N N     . PHE A 1 182 ? 28.062  70.063  48.248  1.00 56.81 ? 475  PHE A N     1 
ATOM   1418 C CA    . PHE A 1 182 ? 29.380  69.515  47.958  1.00 63.89 ? 475  PHE A CA    1 
ATOM   1419 C C     . PHE A 1 182 ? 29.879  68.660  49.120  1.00 67.58 ? 475  PHE A C     1 
ATOM   1420 O O     . PHE A 1 182 ? 30.451  67.593  48.898  1.00 67.22 ? 475  PHE A O     1 
ATOM   1421 C CB    . PHE A 1 182 ? 30.394  70.634  47.701  1.00 63.01 ? 475  PHE A CB    1 
ATOM   1422 C CG    . PHE A 1 182 ? 30.212  71.418  46.425  1.00 62.57 ? 475  PHE A CG    1 
ATOM   1423 C CD1   . PHE A 1 182 ? 29.255  71.068  45.483  1.00 60.88 ? 475  PHE A CD1   1 
ATOM   1424 C CD2   . PHE A 1 182 ? 31.021  72.514  46.166  1.00 61.53 ? 475  PHE A CD2   1 
ATOM   1425 C CE1   . PHE A 1 182 ? 29.110  71.804  44.317  1.00 61.42 ? 475  PHE A CE1   1 
ATOM   1426 C CE2   . PHE A 1 182 ? 30.874  73.248  44.998  1.00 61.27 ? 475  PHE A CE2   1 
ATOM   1427 C CZ    . PHE A 1 182 ? 29.919  72.891  44.076  1.00 58.72 ? 475  PHE A CZ    1 
ATOM   1428 N N     . ARG A 1 183 ? 29.681  69.161  50.346  1.00 67.32 ? 476  ARG A N     1 
ATOM   1429 C CA    . ARG A 1 183 ? 30.042  68.436  51.553  1.00 73.21 ? 476  ARG A CA    1 
ATOM   1430 C C     . ARG A 1 183 ? 29.362  67.070  51.542  1.00 71.88 ? 476  ARG A C     1 
ATOM   1431 O O     . ARG A 1 183 ? 30.035  66.046  51.623  1.00 79.48 ? 476  ARG A O     1 
ATOM   1432 C CB    . ARG A 1 183 ? 29.656  69.240  52.799  1.00 73.97 ? 476  ARG A CB    1 
ATOM   1433 C CG    . ARG A 1 183 ? 29.980  68.549  54.118  1.00 74.38 ? 476  ARG A CG    1 
ATOM   1434 C CD    . ARG A 1 183 ? 29.901  69.487  55.307  1.00 72.20 ? 476  ARG A CD    1 
ATOM   1435 N NE    . ARG A 1 183 ? 28.652  70.237  55.354  1.00 73.46 ? 476  ARG A NE    1 
ATOM   1436 C CZ    . ARG A 1 183 ? 27.459  69.727  55.653  1.00 72.41 ? 476  ARG A CZ    1 
ATOM   1437 N NH1   . ARG A 1 183 ? 27.365  68.586  56.313  1.00 63.91 ? 476  ARG A NH1   1 
ATOM   1438 N NH2   . ARG A 1 183 ? 26.360  70.379  55.306  1.00 69.84 ? 476  ARG A NH2   1 
ATOM   1439 N N     . LEU A 1 184 ? 28.031  67.072  51.396  1.00 70.79 ? 477  LEU A N     1 
ATOM   1440 C CA    . LEU A 1 184 ? 27.226  65.862  51.464  1.00 63.89 ? 477  LEU A CA    1 
ATOM   1441 C C     . LEU A 1 184 ? 27.565  64.921  50.313  1.00 64.85 ? 477  LEU A C     1 
ATOM   1442 O O     . LEU A 1 184 ? 27.341  63.717  50.414  1.00 61.99 ? 477  LEU A O     1 
ATOM   1443 C CB    . LEU A 1 184 ? 25.750  66.259  51.434  1.00 65.00 ? 477  LEU A CB    1 
ATOM   1444 C CG    . LEU A 1 184 ? 25.252  67.012  52.666  1.00 64.36 ? 477  LEU A CG    1 
ATOM   1445 C CD1   . LEU A 1 184 ? 23.943  67.729  52.374  1.00 63.80 ? 477  LEU A CD1   1 
ATOM   1446 C CD2   . LEU A 1 184 ? 25.080  66.065  53.845  1.00 61.86 ? 477  LEU A CD2   1 
ATOM   1447 N N     . ALA A 1 185 ? 28.092  65.482  49.220  1.00 65.01 ? 478  ALA A N     1 
ATOM   1448 C CA    . ALA A 1 185 ? 28.566  64.697  48.091  1.00 71.77 ? 478  ALA A CA    1 
ATOM   1449 C C     . ALA A 1 185 ? 29.998  64.211  48.325  1.00 73.71 ? 478  ALA A C     1 
ATOM   1450 O O     . ALA A 1 185 ? 30.422  63.199  47.763  1.00 66.13 ? 478  ALA A O     1 
ATOM   1451 C CB    . ALA A 1 185 ? 28.476  65.535  46.838  1.00 71.68 ? 478  ALA A CB    1 
ATOM   1452 N N     . GLY A 1 186 ? 30.761  64.975  49.115  1.00 77.76 ? 479  GLY A N     1 
ATOM   1453 C CA    . GLY A 1 186 ? 32.154  64.659  49.382  1.00 79.14 ? 479  GLY A CA    1 
ATOM   1454 C C     . GLY A 1 186 ? 33.074  65.075  48.235  1.00 81.72 ? 479  GLY A C     1 
ATOM   1455 O O     . GLY A 1 186 ? 34.268  64.790  48.268  1.00 88.10 ? 479  GLY A O     1 
ATOM   1456 N N     . HIS A 1 187 ? 32.513  65.737  47.216  1.00 75.84 ? 480  HIS A N     1 
ATOM   1457 C CA    . HIS A 1 187 ? 33.304  66.307  46.141  1.00 69.93 ? 480  HIS A CA    1 
ATOM   1458 C C     . HIS A 1 187 ? 32.502  67.423  45.482  1.00 67.19 ? 480  HIS A C     1 
ATOM   1459 O O     . HIS A 1 187 ? 31.276  67.438  45.568  1.00 61.76 ? 480  HIS A O     1 
ATOM   1460 C CB    . HIS A 1 187 ? 33.725  65.233  45.124  1.00 75.94 ? 480  HIS A CB    1 
ATOM   1461 C CG    . HIS A 1 187 ? 32.640  64.704  44.232  1.00 74.42 ? 480  HIS A CG    1 
ATOM   1462 N ND1   . HIS A 1 187 ? 32.560  64.983  42.889  1.00 75.51 ? 480  HIS A ND1   1 
ATOM   1463 C CD2   . HIS A 1 187 ? 31.593  63.884  44.527  1.00 71.83 ? 480  HIS A CD2   1 
ATOM   1464 C CE1   . HIS A 1 187 ? 31.502  64.362  42.374  1.00 70.95 ? 480  HIS A CE1   1 
ATOM   1465 N NE2   . HIS A 1 187 ? 30.890  63.671  43.373  1.00 71.02 ? 480  HIS A NE2   1 
ATOM   1466 N N     . PRO A 1 188 ? 33.167  68.407  44.835  1.00 66.52 ? 481  PRO A N     1 
ATOM   1467 C CA    . PRO A 1 188 ? 32.460  69.475  44.134  1.00 63.86 ? 481  PRO A CA    1 
ATOM   1468 C C     . PRO A 1 188 ? 31.962  68.959  42.788  1.00 62.85 ? 481  PRO A C     1 
ATOM   1469 O O     . PRO A 1 188 ? 32.443  67.935  42.296  1.00 60.94 ? 481  PRO A O     1 
ATOM   1470 C CB    . PRO A 1 188 ? 33.543  70.554  43.983  1.00 63.60 ? 481  PRO A CB    1 
ATOM   1471 C CG    . PRO A 1 188 ? 34.815  69.744  43.813  1.00 63.52 ? 481  PRO A CG    1 
ATOM   1472 C CD    . PRO A 1 188 ? 34.629  68.540  44.716  1.00 64.86 ? 481  PRO A CD    1 
ATOM   1473 N N     . PHE A 1 189 ? 30.974  69.668  42.227  1.00 57.91 ? 482  PHE A N     1 
ATOM   1474 C CA    . PHE A 1 189 ? 30.506  69.433  40.871  1.00 50.92 ? 482  PHE A CA    1 
ATOM   1475 C C     . PHE A 1 189 ? 29.595  70.587  40.454  1.00 48.89 ? 482  PHE A C     1 
ATOM   1476 O O     . PHE A 1 189 ? 29.347  71.513  41.232  1.00 44.96 ? 482  PHE A O     1 
ATOM   1477 C CB    . PHE A 1 189 ? 29.813  68.072  40.757  1.00 49.00 ? 482  PHE A CB    1 
ATOM   1478 C CG    . PHE A 1 189 ? 28.572  67.921  41.596  1.00 52.55 ? 482  PHE A CG    1 
ATOM   1479 C CD1   . PHE A 1 189 ? 28.658  67.730  42.966  1.00 51.30 ? 482  PHE A CD1   1 
ATOM   1480 C CD2   . PHE A 1 189 ? 27.314  67.989  41.016  1.00 52.92 ? 482  PHE A CD2   1 
ATOM   1481 C CE1   . PHE A 1 189 ? 27.515  67.589  43.738  1.00 52.93 ? 482  PHE A CE1   1 
ATOM   1482 C CE2   . PHE A 1 189 ? 26.170  67.851  41.789  1.00 55.31 ? 482  PHE A CE2   1 
ATOM   1483 C CZ    . PHE A 1 189 ? 26.272  67.652  43.150  1.00 54.76 ? 482  PHE A CZ    1 
ATOM   1484 N N     . ASN A 1 190 ? 29.139  70.532  39.196  1.00 46.71 ? 483  ASN A N     1 
ATOM   1485 C CA    . ASN A 1 190 ? 28.185  71.488  38.659  1.00 45.73 ? 483  ASN A CA    1 
ATOM   1486 C C     . ASN A 1 190 ? 26.777  71.050  39.062  1.00 44.09 ? 483  ASN A C     1 
ATOM   1487 O O     . ASN A 1 190 ? 26.240  70.100  38.492  1.00 42.98 ? 483  ASN A O     1 
ATOM   1488 C CB    . ASN A 1 190 ? 28.334  71.594  37.135  1.00 45.97 ? 483  ASN A CB    1 
ATOM   1489 C CG    . ASN A 1 190 ? 27.677  72.826  36.560  1.00 43.43 ? 483  ASN A CG    1 
ATOM   1490 O OD1   . ASN A 1 190 ? 26.849  73.452  37.216  1.00 39.77 ? 483  ASN A OD1   1 
ATOM   1491 N ND2   . ASN A 1 190 ? 28.042  73.180  35.338  1.00 47.00 ? 483  ASN A ND2   1 
ATOM   1492 N N     . LEU A 1 191 ? 26.191  71.746  40.047  1.00 45.74 ? 484  LEU A N     1 
ATOM   1493 C CA    . LEU A 1 191 ? 24.818  71.492  40.469  1.00 49.02 ? 484  LEU A CA    1 
ATOM   1494 C C     . LEU A 1 191 ? 23.830  71.779  39.340  1.00 49.39 ? 484  LEU A C     1 
ATOM   1495 O O     . LEU A 1 191 ? 22.781  71.140  39.294  1.00 43.24 ? 484  LEU A O     1 
ATOM   1496 C CB    . LEU A 1 191 ? 24.467  72.325  41.708  1.00 48.89 ? 484  LEU A CB    1 
ATOM   1497 C CG    . LEU A 1 191 ? 24.399  71.539  43.015  1.00 49.39 ? 484  LEU A CG    1 
ATOM   1498 C CD1   . LEU A 1 191 ? 25.776  71.054  43.428  1.00 53.97 ? 484  LEU A CD1   1 
ATOM   1499 C CD2   . LEU A 1 191 ? 23.784  72.377  44.119  1.00 51.01 ? 484  LEU A CD2   1 
ATOM   1500 N N     . ASN A 1 192 ? 24.185  72.713  38.439  1.00 49.32 ? 485  ASN A N     1 
ATOM   1501 C CA    . ASN A 1 192 ? 23.346  73.077  37.305  1.00 48.18 ? 485  ASN A CA    1 
ATOM   1502 C C     . ASN A 1 192 ? 23.261  71.956  36.269  1.00 43.47 ? 485  ASN A C     1 
ATOM   1503 O O     . ASN A 1 192 ? 22.476  72.070  35.334  1.00 40.36 ? 485  ASN A O     1 
ATOM   1504 C CB    . ASN A 1 192 ? 23.875  74.297  36.542  1.00 51.23 ? 485  ASN A CB    1 
ATOM   1505 C CG    . ASN A 1 192 ? 23.872  75.598  37.312  1.00 50.63 ? 485  ASN A CG    1 
ATOM   1506 O OD1   . ASN A 1 192 ? 24.441  76.582  36.847  1.00 59.94 ? 485  ASN A OD1   1 
ATOM   1507 N ND2   . ASN A 1 192 ? 23.233  75.632  38.467  1.00 56.06 ? 485  ASN A ND2   1 
ATOM   1508 N N     . SER A 1 193 ? 24.119  70.931  36.376  1.00 42.51 ? 486  SER A N     1 
ATOM   1509 C CA    . SER A 1 193 ? 24.168  69.860  35.392  1.00 39.51 ? 486  SER A CA    1 
ATOM   1510 C C     . SER A 1 193 ? 23.339  68.696  35.897  1.00 40.21 ? 486  SER A C     1 
ATOM   1511 O O     . SER A 1 193 ? 23.662  68.105  36.922  1.00 41.65 ? 486  SER A O     1 
ATOM   1512 C CB    . SER A 1 193 ? 25.577  69.401  35.093  1.00 41.28 ? 486  SER A CB    1 
ATOM   1513 O OG    . SER A 1 193 ? 25.579  68.171  34.373  1.00 37.15 ? 486  SER A OG    1 
ATOM   1514 N N     . ARG A 1 194 ? 22.289  68.362  35.152  1.00 37.42 ? 487  ARG A N     1 
ATOM   1515 C CA    . ARG A 1 194 ? 21.380  67.322  35.588  1.00 39.69 ? 487  ARG A CA    1 
ATOM   1516 C C     . ARG A 1 194 ? 22.050  65.973  35.346  1.00 40.11 ? 487  ARG A C     1 
ATOM   1517 O O     . ARG A 1 194 ? 21.688  65.000  35.994  1.00 39.69 ? 487  ARG A O     1 
ATOM   1518 C CB    . ARG A 1 194 ? 19.988  67.493  34.956  1.00 41.37 ? 487  ARG A CB    1 
ATOM   1519 C CG    . ARG A 1 194 ? 19.914  67.467  33.431  1.00 40.06 ? 487  ARG A CG    1 
ATOM   1520 C CD    . ARG A 1 194 ? 19.916  66.080  32.801  1.00 39.84 ? 487  ARG A CD    1 
ATOM   1521 N NE    . ARG A 1 194 ? 18.877  65.184  33.300  1.00 39.60 ? 487  ARG A NE    1 
ATOM   1522 C CZ    . ARG A 1 194 ? 19.062  63.904  33.626  1.00 40.20 ? 487  ARG A CZ    1 
ATOM   1523 N NH1   . ARG A 1 194 ? 20.201  63.292  33.332  1.00 36.68 ? 487  ARG A NH1   1 
ATOM   1524 N NH2   . ARG A 1 194 ? 18.093  63.236  34.229  1.00 37.77 ? 487  ARG A NH2   1 
ATOM   1525 N N     . ASP A 1 195 ? 23.029  65.930  34.431  1.00 40.70 ? 488  ASP A N     1 
ATOM   1526 C CA    . ASP A 1 195 ? 23.792  64.714  34.183  1.00 44.45 ? 488  ASP A CA    1 
ATOM   1527 C C     . ASP A 1 195 ? 24.673  64.417  35.399  1.00 40.94 ? 488  ASP A C     1 
ATOM   1528 O O     . ASP A 1 195 ? 24.567  63.347  35.992  1.00 42.64 ? 488  ASP A O     1 
ATOM   1529 C CB    . ASP A 1 195 ? 24.605  64.812  32.883  1.00 46.41 ? 488  ASP A CB    1 
ATOM   1530 C CG    . ASP A 1 195 ? 23.821  64.589  31.592  1.00 49.69 ? 488  ASP A CG    1 
ATOM   1531 O OD1   . ASP A 1 195 ? 22.665  64.087  31.659  1.00 47.66 ? 488  ASP A OD1   1 
ATOM   1532 O OD2   . ASP A 1 195 ? 24.371  64.933  30.513  1.00 47.62 ? 488  ASP A OD2   1 
ATOM   1533 N N     . GLN A 1 196 ? 25.521  65.381  35.779  1.00 41.81 ? 489  GLN A N     1 
ATOM   1534 C CA    . GLN A 1 196 ? 26.368  65.256  36.958  1.00 44.06 ? 489  GLN A CA    1 
ATOM   1535 C C     . GLN A 1 196 ? 25.524  64.930  38.194  1.00 45.47 ? 489  GLN A C     1 
ATOM   1536 O O     . GLN A 1 196 ? 25.889  64.086  39.013  1.00 43.61 ? 489  GLN A O     1 
ATOM   1537 C CB    . GLN A 1 196 ? 27.178  66.540  37.164  1.00 43.74 ? 489  GLN A CB    1 
ATOM   1538 C CG    . GLN A 1 196 ? 28.335  66.698  36.182  1.00 41.97 ? 489  GLN A CG    1 
ATOM   1539 C CD    . GLN A 1 196 ? 29.067  68.004  36.372  1.00 45.11 ? 489  GLN A CD    1 
ATOM   1540 O OE1   . GLN A 1 196 ? 29.255  68.478  37.491  1.00 45.85 ? 489  GLN A OE1   1 
ATOM   1541 N NE2   . GLN A 1 196 ? 29.457  68.623  35.269  1.00 45.03 ? 489  GLN A NE2   1 
ATOM   1542 N N     . LEU A 1 197 ? 24.374  65.592  38.326  1.00 43.54 ? 490  LEU A N     1 
ATOM   1543 C CA    . LEU A 1 197 ? 23.512  65.401  39.481  1.00 43.03 ? 490  LEU A CA    1 
ATOM   1544 C C     . LEU A 1 197 ? 22.937  63.980  39.496  1.00 42.14 ? 490  LEU A C     1 
ATOM   1545 O O     . LEU A 1 197 ? 22.832  63.376  40.561  1.00 43.09 ? 490  LEU A O     1 
ATOM   1546 C CB    . LEU A 1 197 ? 22.427  66.480  39.431  1.00 45.12 ? 490  LEU A CB    1 
ATOM   1547 C CG    . LEU A 1 197 ? 21.580  66.651  40.685  1.00 46.45 ? 490  LEU A CG    1 
ATOM   1548 C CD1   . LEU A 1 197 ? 22.424  67.162  41.842  1.00 46.63 ? 490  LEU A CD1   1 
ATOM   1549 C CD2   . LEU A 1 197 ? 20.416  67.600  40.418  1.00 46.44 ? 490  LEU A CD2   1 
ATOM   1550 N N     . GLU A 1 198 ? 22.586  63.441  38.320  1.00 40.63 ? 491  GLU A N     1 
ATOM   1551 C CA    . GLU A 1 198 ? 22.034  62.094  38.199  1.00 43.84 ? 491  GLU A CA    1 
ATOM   1552 C C     . GLU A 1 198 ? 23.072  61.046  38.624  1.00 50.79 ? 491  GLU A C     1 
ATOM   1553 O O     . GLU A 1 198 ? 22.707  59.996  39.149  1.00 52.36 ? 491  GLU A O     1 
ATOM   1554 C CB    . GLU A 1 198 ? 21.599  61.818  36.756  1.00 44.80 ? 491  GLU A CB    1 
ATOM   1555 C CG    . GLU A 1 198 ? 21.032  60.418  36.519  1.00 43.13 ? 491  GLU A CG    1 
ATOM   1556 C CD    . GLU A 1 198 ? 20.855  60.009  35.068  1.00 44.82 ? 491  GLU A CD    1 
ATOM   1557 O OE1   . GLU A 1 198 ? 21.134  60.836  34.183  1.00 49.52 ? 491  GLU A OE1   1 
ATOM   1558 O OE2   . GLU A 1 198 ? 20.429  58.867  34.823  1.00 47.49 ? 491  GLU A OE2   1 
ATOM   1559 N N     . ARG A 1 199 ? 24.359  61.317  38.364  1.00 54.20 ? 492  ARG A N     1 
ATOM   1560 C CA    . ARG A 1 199 ? 25.434  60.467  38.861  1.00 60.15 ? 492  ARG A CA    1 
ATOM   1561 C C     . ARG A 1 199 ? 25.461  60.533  40.389  1.00 56.96 ? 492  ARG A C     1 
ATOM   1562 O O     . ARG A 1 199 ? 25.219  59.533  41.064  1.00 56.11 ? 492  ARG A O     1 
ATOM   1563 C CB    . ARG A 1 199 ? 26.793  60.870  38.270  1.00 61.91 ? 492  ARG A CB    1 
ATOM   1564 C CG    . ARG A 1 199 ? 27.373  59.885  37.263  1.00 67.57 ? 492  ARG A CG    1 
ATOM   1565 C CD    . ARG A 1 199 ? 26.888  60.051  35.832  1.00 70.00 ? 492  ARG A CD    1 
ATOM   1566 N NE    . ARG A 1 199 ? 27.213  61.351  35.254  1.00 75.66 ? 492  ARG A NE    1 
ATOM   1567 C CZ    . ARG A 1 199 ? 28.442  61.836  35.084  1.00 77.47 ? 492  ARG A CZ    1 
ATOM   1568 N NH1   . ARG A 1 199 ? 29.500  61.082  35.322  1.00 78.98 ? 492  ARG A NH1   1 
ATOM   1569 N NH2   . ARG A 1 199 ? 28.608  63.081  34.664  1.00 77.62 ? 492  ARG A NH2   1 
ATOM   1570 N N     . VAL A 1 200 ? 25.713  61.740  40.911  1.00 54.00 ? 493  VAL A N     1 
ATOM   1571 C CA    . VAL A 1 200 ? 25.861  61.975  42.336  1.00 49.56 ? 493  VAL A CA    1 
ATOM   1572 C C     . VAL A 1 200 ? 24.749  61.270  43.107  1.00 51.18 ? 493  VAL A C     1 
ATOM   1573 O O     . VAL A 1 200 ? 25.035  60.515  44.039  1.00 49.18 ? 493  VAL A O     1 
ATOM   1574 C CB    . VAL A 1 200 ? 25.899  63.481  42.659  1.00 52.15 ? 493  VAL A CB    1 
ATOM   1575 C CG1   . VAL A 1 200 ? 25.724  63.754  44.149  1.00 54.12 ? 493  VAL A CG1   1 
ATOM   1576 C CG2   . VAL A 1 200 ? 27.171  64.145  42.140  1.00 51.66 ? 493  VAL A CG2   1 
ATOM   1577 N N     . LEU A 1 201 ? 23.494  61.523  42.717  1.00 46.38 ? 494  LEU A N     1 
ATOM   1578 C CA    . LEU A 1 201 ? 22.339  61.128  43.510  1.00 46.87 ? 494  LEU A CA    1 
ATOM   1579 C C     . LEU A 1 201 ? 22.105  59.620  43.454  1.00 48.70 ? 494  LEU A C     1 
ATOM   1580 O O     . LEU A 1 201 ? 21.766  59.020  44.471  1.00 49.83 ? 494  LEU A O     1 
ATOM   1581 C CB    . LEU A 1 201 ? 21.083  61.861  43.020  1.00 46.48 ? 494  LEU A CB    1 
ATOM   1582 C CG    . LEU A 1 201 ? 20.966  63.336  43.404  1.00 48.20 ? 494  LEU A CG    1 
ATOM   1583 C CD1   . LEU A 1 201 ? 19.621  63.896  42.974  1.00 46.08 ? 494  LEU A CD1   1 
ATOM   1584 C CD2   . LEU A 1 201 ? 21.162  63.541  44.897  1.00 47.67 ? 494  LEU A CD2   1 
ATOM   1585 N N     . PHE A 1 202 ? 22.220  59.019  42.266  1.00 50.21 ? 495  PHE A N     1 
ATOM   1586 C CA    . PHE A 1 202 ? 21.679  57.679  42.059  1.00 52.00 ? 495  PHE A CA    1 
ATOM   1587 C C     . PHE A 1 202 ? 22.781  56.630  41.903  1.00 51.28 ? 495  PHE A C     1 
ATOM   1588 O O     . PHE A 1 202 ? 22.512  55.441  42.069  1.00 51.49 ? 495  PHE A O     1 
ATOM   1589 C CB    . PHE A 1 202 ? 20.767  57.651  40.832  1.00 51.28 ? 495  PHE A CB    1 
ATOM   1590 C CG    . PHE A 1 202 ? 19.628  58.640  40.863  1.00 52.33 ? 495  PHE A CG    1 
ATOM   1591 C CD1   . PHE A 1 202 ? 18.787  58.727  41.964  1.00 51.57 ? 495  PHE A CD1   1 
ATOM   1592 C CD2   . PHE A 1 202 ? 19.383  59.472  39.779  1.00 50.21 ? 495  PHE A CD2   1 
ATOM   1593 C CE1   . PHE A 1 202 ? 17.733  59.629  41.984  1.00 52.28 ? 495  PHE A CE1   1 
ATOM   1594 C CE2   . PHE A 1 202 ? 18.323  60.369  39.798  1.00 51.41 ? 495  PHE A CE2   1 
ATOM   1595 C CZ    . PHE A 1 202 ? 17.497  60.443  40.897  1.00 50.68 ? 495  PHE A CZ    1 
ATOM   1596 N N     . ASP A 1 203 ? 23.988  57.066  41.523  1.00 52.62 ? 496  ASP A N     1 
ATOM   1597 C CA    . ASP A 1 203 ? 25.145  56.184  41.468  1.00 56.30 ? 496  ASP A CA    1 
ATOM   1598 C C     . ASP A 1 203 ? 25.913  56.305  42.789  1.00 55.98 ? 496  ASP A C     1 
ATOM   1599 O O     . ASP A 1 203 ? 25.864  55.397  43.612  1.00 60.79 ? 496  ASP A O     1 
ATOM   1600 C CB    . ASP A 1 203 ? 26.019  56.480  40.241  1.00 52.06 ? 496  ASP A CB    1 
ATOM   1601 C CG    . ASP A 1 203 ? 25.452  56.047  38.893  1.00 54.04 ? 496  ASP A CG    1 
ATOM   1602 O OD1   . ASP A 1 203 ? 24.523  55.195  38.864  1.00 50.44 ? 496  ASP A OD1   1 
ATOM   1603 O OD2   . ASP A 1 203 ? 25.946  56.572  37.867  1.00 53.81 ? 496  ASP A OD2   1 
ATOM   1604 N N     . GLU A 1 204 ? 26.554  57.462  43.010  1.00 55.94 ? 497  GLU A N     1 
ATOM   1605 C CA    . GLU A 1 204 ? 27.462  57.673  44.130  1.00 55.23 ? 497  GLU A CA    1 
ATOM   1606 C C     . GLU A 1 204 ? 26.744  57.479  45.469  1.00 58.84 ? 497  GLU A C     1 
ATOM   1607 O O     . GLU A 1 204 ? 27.234  56.730  46.312  1.00 65.60 ? 497  GLU A O     1 
ATOM   1608 C CB    . GLU A 1 204 ? 28.119  59.055  44.056  1.00 51.48 ? 497  GLU A CB    1 
ATOM   1609 C CG    . GLU A 1 204 ? 28.914  59.287  42.782  1.00 48.97 ? 497  GLU A CG    1 
ATOM   1610 C CD    . GLU A 1 204 ? 29.676  60.603  42.726  1.00 51.60 ? 497  GLU A CD    1 
ATOM   1611 O OE1   . GLU A 1 204 ? 29.622  61.370  43.703  1.00 53.88 ? 497  GLU A OE1   1 
ATOM   1612 O OE2   . GLU A 1 204 ? 30.324  60.862  41.700  1.00 54.56 ? 497  GLU A OE2   1 
ATOM   1613 N N     . LEU A 1 205 ? 25.588  58.134  45.662  1.00 54.94 ? 498  LEU A N     1 
ATOM   1614 C CA    . LEU A 1 205 ? 24.868  58.075  46.928  1.00 49.80 ? 498  LEU A CA    1 
ATOM   1615 C C     . LEU A 1 205 ? 23.832  56.955  46.933  1.00 48.30 ? 498  LEU A C     1 
ATOM   1616 O O     . LEU A 1 205 ? 23.220  56.709  47.969  1.00 52.44 ? 498  LEU A O     1 
ATOM   1617 C CB    . LEU A 1 205 ? 24.182  59.420  47.187  1.00 51.74 ? 498  LEU A CB    1 
ATOM   1618 C CG    . LEU A 1 205 ? 25.110  60.601  47.462  1.00 53.04 ? 498  LEU A CG    1 
ATOM   1619 C CD1   . LEU A 1 205 ? 24.296  61.847  47.770  1.00 50.60 ? 498  LEU A CD1   1 
ATOM   1620 C CD2   . LEU A 1 205 ? 26.074  60.293  48.606  1.00 55.43 ? 498  LEU A CD2   1 
ATOM   1621 N N     . GLY A 1 206 ? 23.582  56.343  45.769  1.00 48.44 ? 499  GLY A N     1 
ATOM   1622 C CA    . GLY A 1 206 ? 22.783  55.131  45.670  1.00 47.77 ? 499  GLY A CA    1 
ATOM   1623 C C     . GLY A 1 206 ? 21.306  55.313  46.015  1.00 52.85 ? 499  GLY A C     1 
ATOM   1624 O O     . GLY A 1 206 ? 20.638  54.339  46.352  1.00 51.65 ? 499  GLY A O     1 
ATOM   1625 N N     . LEU A 1 207 ? 20.773  56.540  45.880  1.00 58.52 ? 500  LEU A N     1 
ATOM   1626 C CA    . LEU A 1 207 ? 19.367  56.798  46.169  1.00 55.50 ? 500  LEU A CA    1 
ATOM   1627 C C     . LEU A 1 207 ? 18.488  56.112  45.121  1.00 52.76 ? 500  LEU A C     1 
ATOM   1628 O O     . LEU A 1 207 ? 18.954  55.829  44.017  1.00 53.00 ? 500  LEU A O     1 
ATOM   1629 C CB    . LEU A 1 207 ? 19.117  58.311  46.179  1.00 56.34 ? 500  LEU A CB    1 
ATOM   1630 C CG    . LEU A 1 207 ? 19.884  59.116  47.228  1.00 55.55 ? 500  LEU A CG    1 
ATOM   1631 C CD1   . LEU A 1 207 ? 19.430  60.567  47.218  1.00 55.15 ? 500  LEU A CD1   1 
ATOM   1632 C CD2   . LEU A 1 207 ? 19.705  58.519  48.616  1.00 55.17 ? 500  LEU A CD2   1 
ATOM   1633 N N     . PRO A 1 208 ? 17.193  55.836  45.422  1.00 51.86 ? 501  PRO A N     1 
ATOM   1634 C CA    . PRO A 1 208 ? 16.282  55.223  44.449  1.00 56.37 ? 501  PRO A CA    1 
ATOM   1635 C C     . PRO A 1 208 ? 15.799  56.193  43.363  1.00 59.32 ? 501  PRO A C     1 
ATOM   1636 O O     . PRO A 1 208 ? 15.321  57.285  43.675  1.00 55.20 ? 501  PRO A O     1 
ATOM   1637 C CB    . PRO A 1 208 ? 15.084  54.759  45.298  1.00 51.07 ? 501  PRO A CB    1 
ATOM   1638 C CG    . PRO A 1 208 ? 15.098  55.647  46.525  1.00 50.69 ? 501  PRO A CG    1 
ATOM   1639 C CD    . PRO A 1 208 ? 16.535  56.090  46.717  1.00 53.77 ? 501  PRO A CD    1 
ATOM   1640 N N     . ALA A 1 209 ? 15.917  55.770  42.094  1.00 57.75 ? 502  ALA A N     1 
ATOM   1641 C CA    . ALA A 1 209 ? 15.444  56.538  40.948  1.00 58.89 ? 502  ALA A CA    1 
ATOM   1642 C C     . ALA A 1 209 ? 14.148  55.927  40.415  1.00 57.76 ? 502  ALA A C     1 
ATOM   1643 O O     . ALA A 1 209 ? 14.184  54.846  39.833  1.00 60.38 ? 502  ALA A O     1 
ATOM   1644 C CB    . ALA A 1 209 ? 16.517  56.557  39.887  1.00 55.81 ? 502  ALA A CB    1 
ATOM   1645 N N     . ILE A 1 210 ? 13.014  56.624  40.600  1.00 60.54 ? 503  ILE A N     1 
ATOM   1646 C CA    . ILE A 1 210 ? 11.701  56.091  40.243  1.00 64.60 ? 503  ILE A CA    1 
ATOM   1647 C C     . ILE A 1 210 ? 11.145  56.754  38.978  1.00 64.14 ? 503  ILE A C     1 
ATOM   1648 O O     . ILE A 1 210 ? 10.109  56.320  38.478  1.00 65.71 ? 503  ILE A O     1 
ATOM   1649 C CB    . ILE A 1 210 ? 10.701  56.241  41.411  1.00 69.03 ? 503  ILE A CB    1 
ATOM   1650 C CG1   . ILE A 1 210 ? 10.373  57.714  41.704  1.00 72.67 ? 503  ILE A CG1   1 
ATOM   1651 C CG2   . ILE A 1 210 ? 11.210  55.505  42.646  1.00 68.58 ? 503  ILE A CG2   1 
ATOM   1652 C CD1   . ILE A 1 210 ? 9.128   57.933  42.539  1.00 69.19 ? 503  ILE A CD1   1 
ATOM   1653 N N     . GLY A 1 211 ? 11.797  57.818  38.488  1.00 58.44 ? 504  GLY A N     1 
ATOM   1654 C CA    . GLY A 1 211 ? 11.312  58.557  37.330  1.00 55.94 ? 504  GLY A CA    1 
ATOM   1655 C C     . GLY A 1 211 ? 12.278  58.467  36.149  1.00 54.45 ? 504  GLY A C     1 
ATOM   1656 O O     . GLY A 1 211 ? 13.492  58.362  36.337  1.00 52.46 ? 504  GLY A O     1 
ATOM   1657 N N     . LYS A 1 212 ? 11.719  58.507  34.933  1.00 54.96 ? 505  LYS A N     1 
ATOM   1658 C CA    . LYS A 1 212 ? 12.502  58.582  33.709  1.00 55.84 ? 505  LYS A CA    1 
ATOM   1659 C C     . LYS A 1 212 ? 12.335  59.967  33.093  1.00 51.53 ? 505  LYS A C     1 
ATOM   1660 O O     . LYS A 1 212 ? 11.330  60.630  33.319  1.00 44.65 ? 505  LYS A O     1 
ATOM   1661 C CB    . LYS A 1 212 ? 12.070  57.487  32.727  1.00 61.04 ? 505  LYS A CB    1 
ATOM   1662 C CG    . LYS A 1 212 ? 12.564  56.091  33.091  1.00 68.74 ? 505  LYS A CG    1 
ATOM   1663 C CD    . LYS A 1 212 ? 14.007  55.825  32.686  1.00 72.40 ? 505  LYS A CD    1 
ATOM   1664 C CE    . LYS A 1 212 ? 14.877  55.309  33.815  1.00 72.31 ? 505  LYS A CE    1 
ATOM   1665 N NZ    . LYS A 1 212 ? 14.288  54.134  34.497  1.00 73.12 ? 505  LYS A NZ    1 
ATOM   1666 N N     . THR A 1 213 ? 13.337  60.394  32.318  1.00 49.29 ? 506  THR A N     1 
ATOM   1667 C CA    . THR A 1 213 ? 13.211  61.590  31.508  1.00 48.10 ? 506  THR A CA    1 
ATOM   1668 C C     . THR A 1 213 ? 12.186  61.314  30.412  1.00 51.73 ? 506  THR A C     1 
ATOM   1669 O O     . THR A 1 213 ? 11.846  60.157  30.171  1.00 51.21 ? 506  THR A O     1 
ATOM   1670 C CB    . THR A 1 213 ? 14.575  62.028  30.970  1.00 46.47 ? 506  THR A CB    1 
ATOM   1671 O OG1   . THR A 1 213 ? 15.120  60.941  30.221  1.00 46.95 ? 506  THR A OG1   1 
ATOM   1672 C CG2   . THR A 1 213 ? 15.528  62.445  32.069  1.00 45.08 ? 506  THR A CG2   1 
ATOM   1673 N N     . GLU A 1 214 ? 11.690  62.384  29.773  1.00 51.60 ? 507  GLU A N     1 
ATOM   1674 C CA    . GLU A 1 214 ? 10.620  62.283  28.791  1.00 54.15 ? 507  GLU A CA    1 
ATOM   1675 C C     . GLU A 1 214 ? 11.092  61.513  27.562  1.00 50.69 ? 507  GLU A C     1 
ATOM   1676 O O     . GLU A 1 214 ? 10.361  60.670  27.052  1.00 48.97 ? 507  GLU A O     1 
ATOM   1677 C CB    . GLU A 1 214 ? 10.124  63.668  28.364  1.00 59.22 ? 507  GLU A CB    1 
ATOM   1678 C CG    . GLU A 1 214 ? 9.429   64.442  29.472  1.00 67.44 ? 507  GLU A CG    1 
ATOM   1679 C CD    . GLU A 1 214 ? 7.955   64.126  29.660  1.00 72.97 ? 507  GLU A CD    1 
ATOM   1680 O OE1   . GLU A 1 214 ? 7.154   64.537  28.798  1.00 78.72 ? 507  GLU A OE1   1 
ATOM   1681 O OE2   . GLU A 1 214 ? 7.611   63.467  30.664  1.00 78.46 ? 507  GLU A OE2   1 
ATOM   1682 N N     . LYS A 1 215 ? 12.310  61.808  27.094  1.00 51.79 ? 508  LYS A N     1 
ATOM   1683 C CA    . LYS A 1 215 ? 12.769  61.294  25.814  1.00 55.62 ? 508  LYS A CA    1 
ATOM   1684 C C     . LYS A 1 215 ? 14.082  60.519  25.951  1.00 53.63 ? 508  LYS A C     1 
ATOM   1685 O O     . LYS A 1 215 ? 14.190  59.448  25.364  1.00 54.70 ? 508  LYS A O     1 
ATOM   1686 C CB    . LYS A 1 215 ? 12.873  62.433  24.793  1.00 60.45 ? 508  LYS A CB    1 
ATOM   1687 C CG    . LYS A 1 215 ? 13.638  62.095  23.519  1.00 67.46 ? 508  LYS A CG    1 
ATOM   1688 C CD    . LYS A 1 215 ? 13.173  62.836  22.275  1.00 73.68 ? 508  LYS A CD    1 
ATOM   1689 C CE    . LYS A 1 215 ? 11.876  62.287  21.717  1.00 78.60 ? 508  LYS A CE    1 
ATOM   1690 N NZ    . LYS A 1 215 ? 11.528  62.910  20.419  1.00 82.44 ? 508  LYS A NZ    1 
ATOM   1691 N N     . THR A 1 216 ? 15.070  61.042  26.700  1.00 52.56 ? 509  THR A N     1 
ATOM   1692 C CA    . THR A 1 216 ? 16.413  60.466  26.720  1.00 49.15 ? 509  THR A CA    1 
ATOM   1693 C C     . THR A 1 216 ? 16.470  59.129  27.474  1.00 51.61 ? 509  THR A C     1 
ATOM   1694 O O     . THR A 1 216 ? 17.501  58.463  27.449  1.00 49.35 ? 509  THR A O     1 
ATOM   1695 C CB    . THR A 1 216 ? 17.458  61.443  27.287  1.00 49.34 ? 509  THR A CB    1 
ATOM   1696 O OG1   . THR A 1 216 ? 17.144  61.801  28.637  1.00 46.64 ? 509  THR A OG1   1 
ATOM   1697 C CG2   . THR A 1 216 ? 17.600  62.698  26.452  1.00 49.04 ? 509  THR A CG2   1 
ATOM   1698 N N     . GLY A 1 217 ? 15.382  58.726  28.145  1.00 58.12 ? 510  GLY A N     1 
ATOM   1699 C CA    . GLY A 1 217 ? 15.328  57.444  28.836  1.00 58.16 ? 510  GLY A CA    1 
ATOM   1700 C C     . GLY A 1 217 ? 16.309  57.350  30.008  1.00 60.49 ? 510  GLY A C     1 
ATOM   1701 O O     . GLY A 1 217 ? 16.708  56.254  30.394  1.00 64.19 ? 510  GLY A O     1 
ATOM   1702 N N     . LYS A 1 218 ? 16.681  58.505  30.579  1.00 57.74 ? 511  LYS A N     1 
ATOM   1703 C CA    . LYS A 1 218 ? 17.575  58.571  31.724  1.00 53.69 ? 511  LYS A CA    1 
ATOM   1704 C C     . LYS A 1 218 ? 16.755  58.654  33.011  1.00 51.26 ? 511  LYS A C     1 
ATOM   1705 O O     . LYS A 1 218 ? 15.526  58.716  32.972  1.00 48.73 ? 511  LYS A O     1 
ATOM   1706 C CB    . LYS A 1 218 ? 18.529  59.762  31.574  1.00 54.40 ? 511  LYS A CB    1 
ATOM   1707 C CG    . LYS A 1 218 ? 19.517  59.653  30.419  1.00 57.91 ? 511  LYS A CG    1 
ATOM   1708 C CD    . LYS A 1 218 ? 20.256  58.318  30.378  1.00 61.03 ? 511  LYS A CD    1 
ATOM   1709 C CE    . LYS A 1 218 ? 21.252  58.219  29.241  1.00 62.04 ? 511  LYS A CE    1 
ATOM   1710 N NZ    . LYS A 1 218 ? 22.291  59.268  29.345  1.00 65.35 ? 511  LYS A NZ    1 
ATOM   1711 N N     . ARG A 1 219 ? 17.449  58.614  34.158  1.00 49.14 ? 512  ARG A N     1 
ATOM   1712 C CA    . ARG A 1 219 ? 16.809  58.755  35.459  1.00 47.28 ? 512  ARG A CA    1 
ATOM   1713 C C     . ARG A 1 219 ? 16.617  60.244  35.746  1.00 42.73 ? 512  ARG A C     1 
ATOM   1714 O O     . ARG A 1 219 ? 17.559  61.030  35.651  1.00 41.27 ? 512  ARG A O     1 
ATOM   1715 C CB    . ARG A 1 219 ? 17.644  58.075  36.554  1.00 49.18 ? 512  ARG A CB    1 
ATOM   1716 C CG    . ARG A 1 219 ? 17.721  56.556  36.446  1.00 48.59 ? 512  ARG A CG    1 
ATOM   1717 C CD    . ARG A 1 219 ? 18.839  55.966  37.292  1.00 48.54 ? 512  ARG A CD    1 
ATOM   1718 N NE    . ARG A 1 219 ? 20.149  56.395  36.820  1.00 51.02 ? 512  ARG A NE    1 
ATOM   1719 C CZ    . ARG A 1 219 ? 21.297  56.173  37.450  1.00 56.22 ? 512  ARG A CZ    1 
ATOM   1720 N NH1   . ARG A 1 219 ? 21.325  55.400  38.521  1.00 60.39 ? 512  ARG A NH1   1 
ATOM   1721 N NH2   . ARG A 1 219 ? 22.411  56.739  37.013  1.00 54.40 ? 512  ARG A NH2   1 
ATOM   1722 N N     . SER A 1 220 ? 15.380  60.619  36.092  1.00 44.34 ? 513  SER A N     1 
ATOM   1723 C CA    . SER A 1 220 ? 14.996  62.017  36.208  1.00 42.48 ? 513  SER A CA    1 
ATOM   1724 C C     . SER A 1 220 ? 15.468  62.578  37.543  1.00 38.98 ? 513  SER A C     1 
ATOM   1725 O O     . SER A 1 220 ? 15.335  61.913  38.561  1.00 45.32 ? 513  SER A O     1 
ATOM   1726 C CB    . SER A 1 220 ? 13.500  62.168  36.033  1.00 41.26 ? 513  SER A CB    1 
ATOM   1727 O OG    . SER A 1 220 ? 13.105  63.517  36.211  1.00 40.75 ? 513  SER A OG    1 
ATOM   1728 N N     . THR A 1 221 ? 16.007  63.805  37.513  1.00 39.40 ? 514  THR A N     1 
ATOM   1729 C CA    . THR A 1 221 ? 16.291  64.596  38.696  1.00 38.82 ? 514  THR A CA    1 
ATOM   1730 C C     . THR A 1 221 ? 15.276  65.734  38.868  1.00 37.79 ? 514  THR A C     1 
ATOM   1731 O O     . THR A 1 221 ? 15.573  66.734  39.529  1.00 40.28 ? 514  THR A O     1 
ATOM   1732 C CB    . THR A 1 221 ? 17.719  65.159  38.642  1.00 42.05 ? 514  THR A CB    1 
ATOM   1733 O OG1   . THR A 1 221 ? 17.820  66.143  37.607  1.00 44.01 ? 514  THR A OG1   1 
ATOM   1734 C CG2   . THR A 1 221 ? 18.759  64.080  38.420  1.00 41.81 ? 514  THR A CG2   1 
ATOM   1735 N N     . SER A 1 222 ? 14.070  65.563  38.323  1.00 37.11 ? 515  SER A N     1 
ATOM   1736 C CA    . SER A 1 222 ? 13.032  66.591  38.380  1.00 38.23 ? 515  SER A CA    1 
ATOM   1737 C C     . SER A 1 222 ? 12.470  66.717  39.792  1.00 41.78 ? 515  SER A C     1 
ATOM   1738 O O     . SER A 1 222 ? 12.659  65.829  40.625  1.00 44.91 ? 515  SER A O     1 
ATOM   1739 C CB    . SER A 1 222 ? 11.921  66.282  37.425  1.00 36.32 ? 515  SER A CB    1 
ATOM   1740 O OG    . SER A 1 222 ? 11.149  65.199  37.916  1.00 37.52 ? 515  SER A OG    1 
ATOM   1741 N N     . ALA A 1 223 ? 11.737  67.807  40.045  1.00 42.87 ? 516  ALA A N     1 
ATOM   1742 C CA    . ALA A 1 223 ? 11.077  68.006  41.326  1.00 42.82 ? 516  ALA A CA    1 
ATOM   1743 C C     . ALA A 1 223 ? 10.154  66.825  41.634  1.00 39.74 ? 516  ALA A C     1 
ATOM   1744 O O     . ALA A 1 223 ? 10.089  66.366  42.771  1.00 42.71 ? 516  ALA A O     1 
ATOM   1745 C CB    . ALA A 1 223 ? 10.317  69.317  41.335  1.00 43.42 ? 516  ALA A CB    1 
ATOM   1746 N N     . ALA A 1 224 ? 9.452   66.321  40.617  1.00 39.31 ? 517  ALA A N     1 
ATOM   1747 C CA    . ALA A 1 224 ? 8.492   65.247  40.821  1.00 40.23 ? 517  ALA A CA    1 
ATOM   1748 C C     . ALA A 1 224 ? 9.215   63.957  41.195  1.00 42.84 ? 517  ALA A C     1 
ATOM   1749 O O     . ALA A 1 224 ? 8.790   63.283  42.126  1.00 46.40 ? 517  ALA A O     1 
ATOM   1750 C CB    . ALA A 1 224 ? 7.628   65.043  39.602  1.00 39.43 ? 517  ALA A CB    1 
ATOM   1751 N N     . ALA A 1 225 ? 10.307  63.642  40.483  1.00 44.38 ? 518  ALA A N     1 
ATOM   1752 C CA    . ALA A 1 225 ? 11.070  62.418  40.693  1.00 45.69 ? 518  ALA A CA    1 
ATOM   1753 C C     . ALA A 1 225 ? 11.695  62.369  42.092  1.00 48.44 ? 518  ALA A C     1 
ATOM   1754 O O     . ALA A 1 225 ? 11.837  61.285  42.651  1.00 54.11 ? 518  ALA A O     1 
ATOM   1755 C CB    . ALA A 1 225 ? 12.136  62.293  39.630  1.00 41.67 ? 518  ALA A CB    1 
ATOM   1756 N N     . LEU A 1 226 ? 12.075  63.544  42.627  1.00 47.20 ? 519  LEU A N     1 
ATOM   1757 C CA    . LEU A 1 226 ? 12.849  63.668  43.852  1.00 45.59 ? 519  LEU A CA    1 
ATOM   1758 C C     . LEU A 1 226 ? 11.959  63.917  45.070  1.00 51.35 ? 519  LEU A C     1 
ATOM   1759 O O     . LEU A 1 226 ? 12.456  63.881  46.195  1.00 51.20 ? 519  LEU A O     1 
ATOM   1760 C CB    . LEU A 1 226 ? 13.836  64.837  43.714  1.00 41.45 ? 519  LEU A CB    1 
ATOM   1761 C CG    . LEU A 1 226 ? 14.969  64.671  42.704  1.00 42.11 ? 519  LEU A CG    1 
ATOM   1762 C CD1   . LEU A 1 226 ? 15.961  65.820  42.825  1.00 41.52 ? 519  LEU A CD1   1 
ATOM   1763 C CD2   . LEU A 1 226 ? 15.667  63.327  42.861  1.00 43.67 ? 519  LEU A CD2   1 
ATOM   1764 N N     . GLU A 1 227 ? 10.665  64.194  44.857  1.00 55.57 ? 520  GLU A N     1 
ATOM   1765 C CA    . GLU A 1 227 ? 9.792   64.681  45.916  1.00 56.19 ? 520  GLU A CA    1 
ATOM   1766 C C     . GLU A 1 227 ? 9.749   63.714  47.104  1.00 58.05 ? 520  GLU A C     1 
ATOM   1767 O O     . GLU A 1 227 ? 9.769   64.154  48.250  1.00 51.02 ? 520  GLU A O     1 
ATOM   1768 C CB    . GLU A 1 227 ? 8.373   64.911  45.385  1.00 58.00 ? 520  GLU A CB    1 
ATOM   1769 C CG    . GLU A 1 227 ? 7.397   65.399  46.447  1.00 58.91 ? 520  GLU A CG    1 
ATOM   1770 C CD    . GLU A 1 227 ? 7.804   66.695  47.129  1.00 61.28 ? 520  GLU A CD    1 
ATOM   1771 O OE1   . GLU A 1 227 ? 8.676   67.406  46.586  1.00 60.91 ? 520  GLU A OE1   1 
ATOM   1772 O OE2   . GLU A 1 227 ? 7.268   66.984  48.214  1.00 63.89 ? 520  GLU A OE2   1 
ATOM   1773 N N     . ALA A 1 228 ? 9.663   62.407  46.827  1.00 59.56 ? 521  ALA A N     1 
ATOM   1774 C CA    . ALA A 1 228 ? 9.476   61.396  47.862  1.00 65.08 ? 521  ALA A CA    1 
ATOM   1775 C C     . ALA A 1 228 ? 10.794  61.016  48.543  1.00 61.20 ? 521  ALA A C     1 
ATOM   1776 O O     . ALA A 1 228 ? 10.781  60.183  49.441  1.00 61.46 ? 521  ALA A O     1 
ATOM   1777 C CB    . ALA A 1 228 ? 8.819   60.169  47.272  1.00 61.84 ? 521  ALA A CB    1 
ATOM   1778 N N     . LEU A 1 229 ? 11.914  61.606  48.102  1.00 61.87 ? 522  LEU A N     1 
ATOM   1779 C CA    . LEU A 1 229 ? 13.226  61.405  48.706  1.00 61.21 ? 522  LEU A CA    1 
ATOM   1780 C C     . LEU A 1 229 ? 13.588  62.578  49.617  1.00 61.71 ? 522  LEU A C     1 
ATOM   1781 O O     . LEU A 1 229 ? 14.710  62.649  50.114  1.00 64.42 ? 522  LEU A O     1 
ATOM   1782 C CB    . LEU A 1 229 ? 14.276  61.285  47.594  1.00 59.71 ? 522  LEU A CB    1 
ATOM   1783 C CG    . LEU A 1 229 ? 14.409  59.918  46.927  1.00 61.65 ? 522  LEU A CG    1 
ATOM   1784 C CD1   . LEU A 1 229 ? 13.095  59.482  46.298  1.00 64.19 ? 522  LEU A CD1   1 
ATOM   1785 C CD2   . LEU A 1 229 ? 15.516  59.947  45.884  1.00 60.98 ? 522  LEU A CD2   1 
ATOM   1786 N N     . ARG A 1 230 ? 12.635  63.486  49.840  1.00 62.37 ? 523  ARG A N     1 
ATOM   1787 C CA    . ARG A 1 230 ? 12.906  64.808  50.385  1.00 60.82 ? 523  ARG A CA    1 
ATOM   1788 C C     . ARG A 1 230 ? 13.097  64.730  51.899  1.00 57.03 ? 523  ARG A C     1 
ATOM   1789 O O     . ARG A 1 230 ? 14.059  65.280  52.427  1.00 54.94 ? 523  ARG A O     1 
ATOM   1790 C CB    . ARG A 1 230 ? 11.717  65.716  50.053  1.00 64.90 ? 523  ARG A CB    1 
ATOM   1791 C CG    . ARG A 1 230 ? 12.018  67.201  49.939  1.00 67.68 ? 523  ARG A CG    1 
ATOM   1792 C CD    . ARG A 1 230 ? 10.711  67.973  49.846  1.00 70.07 ? 523  ARG A CD    1 
ATOM   1793 N NE    . ARG A 1 230 ? 10.680  68.886  48.713  1.00 73.82 ? 523  ARG A NE    1 
ATOM   1794 C CZ    . ARG A 1 230 ? 11.034  70.165  48.757  1.00 75.85 ? 523  ARG A CZ    1 
ATOM   1795 N NH1   . ARG A 1 230 ? 11.556  70.673  49.858  1.00 77.71 ? 523  ARG A NH1   1 
ATOM   1796 N NH2   . ARG A 1 230 ? 10.898  70.927  47.685  1.00 81.35 ? 523  ARG A NH2   1 
ATOM   1797 N N     . GLU A 1 231 ? 12.143  64.074  52.581  1.00 58.58 ? 524  GLU A N     1 
ATOM   1798 C CA    . GLU A 1 231 ? 12.112  63.994  54.037  1.00 61.10 ? 524  GLU A CA    1 
ATOM   1799 C C     . GLU A 1 231 ? 13.302  63.176  54.542  1.00 62.17 ? 524  GLU A C     1 
ATOM   1800 O O     . GLU A 1 231 ? 13.978  63.589  55.481  1.00 59.43 ? 524  GLU A O     1 
ATOM   1801 C CB    . GLU A 1 231 ? 10.798  63.370  54.519  1.00 56.66 ? 524  GLU A CB    1 
ATOM   1802 N N     . ALA A 1 232 ? 13.573  62.038  53.886  1.00 62.43 ? 525  ALA A N     1 
ATOM   1803 C CA    . ALA A 1 232 ? 14.580  61.096  54.353  1.00 62.61 ? 525  ALA A CA    1 
ATOM   1804 C C     . ALA A 1 232 ? 15.991  61.533  53.965  1.00 61.33 ? 525  ALA A C     1 
ATOM   1805 O O     . ALA A 1 232 ? 16.949  60.996  54.514  1.00 63.20 ? 525  ALA A O     1 
ATOM   1806 C CB    . ALA A 1 232 ? 14.284  59.710  53.828  1.00 60.25 ? 525  ALA A CB    1 
ATOM   1807 N N     . HIS A 1 233 ? 16.129  62.482  53.025  1.00 60.36 ? 526  HIS A N     1 
ATOM   1808 C CA    . HIS A 1 233 ? 17.437  62.814  52.475  1.00 58.30 ? 526  HIS A CA    1 
ATOM   1809 C C     . HIS A 1 233 ? 17.614  64.323  52.330  1.00 63.70 ? 526  HIS A C     1 
ATOM   1810 O O     . HIS A 1 233 ? 17.263  64.908  51.309  1.00 66.35 ? 526  HIS A O     1 
ATOM   1811 C CB    . HIS A 1 233 ? 17.643  62.105  51.135  1.00 59.70 ? 526  HIS A CB    1 
ATOM   1812 C CG    . HIS A 1 233 ? 17.514  60.619  51.214  1.00 57.56 ? 526  HIS A CG    1 
ATOM   1813 N ND1   . HIS A 1 233 ? 18.481  59.801  51.738  1.00 57.27 ? 526  HIS A ND1   1 
ATOM   1814 C CD2   . HIS A 1 233 ? 16.476  59.824  50.831  1.00 57.71 ? 526  HIS A CD2   1 
ATOM   1815 C CE1   . HIS A 1 233 ? 18.059  58.540  51.676  1.00 60.56 ? 526  HIS A CE1   1 
ATOM   1816 N NE2   . HIS A 1 233 ? 16.811  58.530  51.118  1.00 57.56 ? 526  HIS A NE2   1 
ATOM   1817 N N     . PRO A 1 234 ? 18.166  64.997  53.361  1.00 64.34 ? 527  PRO A N     1 
ATOM   1818 C CA    . PRO A 1 234 ? 18.509  66.421  53.282  1.00 64.65 ? 527  PRO A CA    1 
ATOM   1819 C C     . PRO A 1 234 ? 19.316  66.948  52.090  1.00 63.96 ? 527  PRO A C     1 
ATOM   1820 O O     . PRO A 1 234 ? 19.236  68.139  51.788  1.00 64.24 ? 527  PRO A O     1 
ATOM   1821 C CB    . PRO A 1 234 ? 19.351  66.609  54.554  1.00 65.15 ? 527  PRO A CB    1 
ATOM   1822 C CG    . PRO A 1 234 ? 18.715  65.658  55.545  1.00 64.84 ? 527  PRO A CG    1 
ATOM   1823 C CD    . PRO A 1 234 ? 18.363  64.443  54.712  1.00 65.82 ? 527  PRO A CD    1 
ATOM   1824 N N     . ILE A 1 235 ? 20.124  66.106  51.429  1.00 59.53 ? 528  ILE A N     1 
ATOM   1825 C CA    . ILE A 1 235 ? 20.865  66.591  50.270  1.00 56.97 ? 528  ILE A CA    1 
ATOM   1826 C C     . ILE A 1 235 ? 19.882  66.950  49.155  1.00 56.20 ? 528  ILE A C     1 
ATOM   1827 O O     . ILE A 1 235 ? 20.094  67.932  48.452  1.00 52.05 ? 528  ILE A O     1 
ATOM   1828 C CB    . ILE A 1 235 ? 21.946  65.615  49.764  1.00 52.96 ? 528  ILE A CB    1 
ATOM   1829 C CG1   . ILE A 1 235 ? 22.905  66.341  48.812  1.00 54.79 ? 528  ILE A CG1   1 
ATOM   1830 C CG2   . ILE A 1 235 ? 21.342  64.369  49.132  1.00 52.28 ? 528  ILE A CG2   1 
ATOM   1831 C CD1   . ILE A 1 235 ? 23.889  65.443  48.107  1.00 56.04 ? 528  ILE A CD1   1 
ATOM   1832 N N     . VAL A 1 236 ? 18.821  66.143  49.010  1.00 53.10 ? 529  VAL A N     1 
ATOM   1833 C CA    . VAL A 1 236 ? 17.775  66.375  48.031  1.00 55.51 ? 529  VAL A CA    1 
ATOM   1834 C C     . VAL A 1 236 ? 17.100  67.712  48.329  1.00 56.27 ? 529  VAL A C     1 
ATOM   1835 O O     . VAL A 1 236 ? 16.952  68.545  47.434  1.00 50.36 ? 529  VAL A O     1 
ATOM   1836 C CB    . VAL A 1 236 ? 16.768  65.210  48.026  1.00 52.54 ? 529  VAL A CB    1 
ATOM   1837 C CG1   . VAL A 1 236 ? 15.480  65.566  47.298  1.00 56.07 ? 529  VAL A CG1   1 
ATOM   1838 C CG2   . VAL A 1 236 ? 17.393  63.947  47.454  1.00 50.93 ? 529  VAL A CG2   1 
ATOM   1839 N N     . GLU A 1 237 ? 16.722  67.896  49.601  1.00 53.76 ? 530  GLU A N     1 
ATOM   1840 C CA    . GLU A 1 237 ? 16.098  69.116  50.096  1.00 53.92 ? 530  GLU A CA    1 
ATOM   1841 C C     . GLU A 1 237 ? 16.917  70.351  49.701  1.00 50.03 ? 530  GLU A C     1 
ATOM   1842 O O     . GLU A 1 237 ? 16.359  71.374  49.316  1.00 45.96 ? 530  GLU A O     1 
ATOM   1843 C CB    . GLU A 1 237 ? 15.949  68.990  51.614  1.00 59.90 ? 530  GLU A CB    1 
ATOM   1844 C CG    . GLU A 1 237 ? 15.404  70.227  52.300  1.00 63.83 ? 530  GLU A CG    1 
ATOM   1845 C CD    . GLU A 1 237 ? 14.067  70.694  51.758  1.00 67.53 ? 530  GLU A CD    1 
ATOM   1846 O OE1   . GLU A 1 237 ? 13.144  69.859  51.677  1.00 71.29 ? 530  GLU A OE1   1 
ATOM   1847 O OE2   . GLU A 1 237 ? 13.953  71.885  51.418  1.00 71.87 ? 530  GLU A OE2   1 
ATOM   1848 N N     . LYS A 1 238 ? 18.246  70.237  49.778  1.00 46.76 ? 531  LYS A N     1 
ATOM   1849 C CA    . LYS A 1 238 ? 19.149  71.341  49.506  1.00 50.23 ? 531  LYS A CA    1 
ATOM   1850 C C     . LYS A 1 238 ? 19.249  71.597  47.997  1.00 47.96 ? 531  LYS A C     1 
ATOM   1851 O O     . LYS A 1 238 ? 19.348  72.746  47.571  1.00 42.23 ? 531  LYS A O     1 
ATOM   1852 C CB    . LYS A 1 238 ? 20.515  71.037  50.132  1.00 57.11 ? 531  LYS A CB    1 
ATOM   1853 C CG    . LYS A 1 238 ? 20.539  71.038  51.658  1.00 60.66 ? 531  LYS A CG    1 
ATOM   1854 C CD    . LYS A 1 238 ? 20.630  72.432  52.252  1.00 65.84 ? 531  LYS A CD    1 
ATOM   1855 C CE    . LYS A 1 238 ? 20.416  72.483  53.751  1.00 67.16 ? 531  LYS A CE    1 
ATOM   1856 N NZ    . LYS A 1 238 ? 18.986  72.305  54.097  1.00 69.38 ? 531  LYS A NZ    1 
ATOM   1857 N N     . ILE A 1 239 ? 19.234  70.524  47.200  1.00 43.08 ? 532  ILE A N     1 
ATOM   1858 C CA    . ILE A 1 239 ? 19.275  70.628  45.752  1.00 45.49 ? 532  ILE A CA    1 
ATOM   1859 C C     . ILE A 1 239 ? 18.042  71.375  45.242  1.00 41.99 ? 532  ILE A C     1 
ATOM   1860 O O     . ILE A 1 239 ? 18.173  72.257  44.395  1.00 39.12 ? 532  ILE A O     1 
ATOM   1861 C CB    . ILE A 1 239 ? 19.416  69.233  45.115  1.00 44.55 ? 532  ILE A CB    1 
ATOM   1862 C CG1   . ILE A 1 239 ? 20.840  68.699  45.282  1.00 46.26 ? 532  ILE A CG1   1 
ATOM   1863 C CG2   . ILE A 1 239 ? 18.998  69.260  43.653  1.00 45.76 ? 532  ILE A CG2   1 
ATOM   1864 C CD1   . ILE A 1 239 ? 20.977  67.200  45.083  1.00 48.73 ? 532  ILE A CD1   1 
ATOM   1865 N N     . LEU A 1 240 ? 16.857  71.021  45.758  1.00 39.62 ? 533  LEU A N     1 
ATOM   1866 C CA    . LEU A 1 240 ? 15.614  71.641  45.313  1.00 41.69 ? 533  LEU A CA    1 
ATOM   1867 C C     . LEU A 1 240 ? 15.618  73.123  45.668  1.00 41.36 ? 533  LEU A C     1 
ATOM   1868 O O     . LEU A 1 240 ? 15.179  73.948  44.878  1.00 42.68 ? 533  LEU A O     1 
ATOM   1869 C CB    . LEU A 1 240 ? 14.411  70.934  45.946  1.00 42.87 ? 533  LEU A CB    1 
ATOM   1870 C CG    . LEU A 1 240 ? 14.154  69.495  45.489  1.00 43.33 ? 533  LEU A CG    1 
ATOM   1871 C CD1   . LEU A 1 240 ? 12.912  68.941  46.162  1.00 46.87 ? 533  LEU A CD1   1 
ATOM   1872 C CD2   . LEU A 1 240 ? 14.010  69.389  43.978  1.00 47.14 ? 533  LEU A CD2   1 
ATOM   1873 N N     . GLN A 1 241 ? 16.149  73.459  46.844  1.00 42.52 ? 534  GLN A N     1 
ATOM   1874 C CA    . GLN A 1 241 ? 16.303  74.848  47.240  1.00 43.04 ? 534  GLN A CA    1 
ATOM   1875 C C     . GLN A 1 241 ? 17.227  75.578  46.270  1.00 38.92 ? 534  GLN A C     1 
ATOM   1876 O O     . GLN A 1 241 ? 16.940  76.706  45.882  1.00 38.61 ? 534  GLN A O     1 
ATOM   1877 C CB    . GLN A 1 241 ? 16.844  74.941  48.665  1.00 46.17 ? 534  GLN A CB    1 
ATOM   1878 C CG    . GLN A 1 241 ? 15.795  74.670  49.730  1.00 49.65 ? 534  GLN A CG    1 
ATOM   1879 C CD    . GLN A 1 241 ? 16.416  74.461  51.090  1.00 53.25 ? 534  GLN A CD    1 
ATOM   1880 O OE1   . GLN A 1 241 ? 17.366  75.142  51.475  1.00 56.63 ? 534  GLN A OE1   1 
ATOM   1881 N NE2   . GLN A 1 241 ? 15.893  73.494  51.824  1.00 49.11 ? 534  GLN A NE2   1 
ATOM   1882 N N     . TYR A 1 242 ? 18.344  74.938  45.908  1.00 36.47 ? 535  TYR A N     1 
ATOM   1883 C CA    . TYR A 1 242 ? 19.316  75.502  44.982  1.00 37.73 ? 535  TYR A CA    1 
ATOM   1884 C C     . TYR A 1 242 ? 18.687  75.713  43.597  1.00 38.40 ? 535  TYR A C     1 
ATOM   1885 O O     . TYR A 1 242 ? 18.905  76.749  42.966  1.00 36.90 ? 535  TYR A O     1 
ATOM   1886 C CB    . TYR A 1 242 ? 20.553  74.595  44.904  1.00 39.28 ? 535  TYR A CB    1 
ATOM   1887 C CG    . TYR A 1 242 ? 21.545  74.962  43.830  1.00 41.64 ? 535  TYR A CG    1 
ATOM   1888 C CD1   . TYR A 1 242 ? 21.368  74.541  42.522  1.00 42.82 ? 535  TYR A CD1   1 
ATOM   1889 C CD2   . TYR A 1 242 ? 22.639  75.770  44.101  1.00 43.50 ? 535  TYR A CD2   1 
ATOM   1890 C CE1   . TYR A 1 242 ? 22.257  74.894  41.520  1.00 44.70 ? 535  TYR A CE1   1 
ATOM   1891 C CE2   . TYR A 1 242 ? 23.545  76.121  43.109  1.00 41.87 ? 535  TYR A CE2   1 
ATOM   1892 C CZ    . TYR A 1 242 ? 23.353  75.686  41.814  1.00 43.36 ? 535  TYR A CZ    1 
ATOM   1893 O OH    . TYR A 1 242 ? 24.224  76.042  40.816  1.00 46.06 ? 535  TYR A OH    1 
ATOM   1894 N N     . ARG A 1 243 ? 17.939  74.704  43.133  1.00 36.03 ? 536  ARG A N     1 
ATOM   1895 C CA    . ARG A 1 243 ? 17.210  74.746  41.873  1.00 39.40 ? 536  ARG A CA    1 
ATOM   1896 C C     . ARG A 1 243 ? 16.331  75.995  41.808  1.00 34.47 ? 536  ARG A C     1 
ATOM   1897 O O     . ARG A 1 243 ? 16.401  76.741  40.848  1.00 33.44 ? 536  ARG A O     1 
ATOM   1898 C CB    . ARG A 1 243 ? 16.334  73.495  41.724  1.00 38.66 ? 536  ARG A CB    1 
ATOM   1899 C CG    . ARG A 1 243 ? 17.058  72.268  41.192  1.00 38.65 ? 536  ARG A CG    1 
ATOM   1900 C CD    . ARG A 1 243 ? 17.024  72.170  39.680  1.00 38.98 ? 536  ARG A CD    1 
ATOM   1901 N NE    . ARG A 1 243 ? 17.601  70.929  39.168  1.00 39.39 ? 536  ARG A NE    1 
ATOM   1902 C CZ    . ARG A 1 243 ? 17.046  69.716  39.236  1.00 37.35 ? 536  ARG A CZ    1 
ATOM   1903 N NH1   . ARG A 1 243 ? 15.825  69.532  39.715  1.00 32.62 ? 536  ARG A NH1   1 
ATOM   1904 N NH2   . ARG A 1 243 ? 17.733  68.673  38.809  1.00 37.12 ? 536  ARG A NH2   1 
ATOM   1905 N N     . GLU A 1 244 ? 15.518  76.212  42.839  1.00 38.10 ? 537  GLU A N     1 
ATOM   1906 C CA    . GLU A 1 244 ? 14.556  77.296  42.834  1.00 42.12 ? 537  GLU A CA    1 
ATOM   1907 C C     . GLU A 1 244 ? 15.271  78.640  42.725  1.00 43.55 ? 537  GLU A C     1 
ATOM   1908 O O     . GLU A 1 244 ? 14.865  79.495  41.937  1.00 40.64 ? 537  GLU A O     1 
ATOM   1909 C CB    . GLU A 1 244 ? 13.688  77.307  44.090  1.00 47.61 ? 537  GLU A CB    1 
ATOM   1910 C CG    . GLU A 1 244 ? 12.419  78.140  43.905  1.00 50.71 ? 537  GLU A CG    1 
ATOM   1911 C CD    . GLU A 1 244 ? 12.083  79.093  45.034  1.00 53.81 ? 537  GLU A CD    1 
ATOM   1912 O OE1   . GLU A 1 244 ? 12.094  78.655  46.205  1.00 64.21 ? 537  GLU A OE1   1 
ATOM   1913 O OE2   . GLU A 1 244 ? 11.782  80.262  44.741  1.00 51.39 ? 537  GLU A OE2   1 
ATOM   1914 N N     . LEU A 1 245 ? 16.335  78.823  43.518  1.00 40.90 ? 538  LEU A N     1 
ATOM   1915 C CA    . LEU A 1 245 ? 17.013  80.110  43.575  1.00 39.68 ? 538  LEU A CA    1 
ATOM   1916 C C     . LEU A 1 245 ? 17.719  80.390  42.251  1.00 35.54 ? 538  LEU A C     1 
ATOM   1917 O O     . LEU A 1 245 ? 17.664  81.515  41.754  1.00 36.24 ? 538  LEU A O     1 
ATOM   1918 C CB    . LEU A 1 245 ? 18.001  80.131  44.750  1.00 41.99 ? 538  LEU A CB    1 
ATOM   1919 C CG    . LEU A 1 245 ? 17.395  79.926  46.139  1.00 43.35 ? 538  LEU A CG    1 
ATOM   1920 C CD1   . LEU A 1 245 ? 18.440  80.135  47.219  1.00 45.48 ? 538  LEU A CD1   1 
ATOM   1921 C CD2   . LEU A 1 245 ? 16.211  80.848  46.380  1.00 43.56 ? 538  LEU A CD2   1 
ATOM   1922 N N     . THR A 1 246 ? 18.378  79.370  41.685  1.00 35.13 ? 539  THR A N     1 
ATOM   1923 C CA    . THR A 1 246 ? 19.145  79.546  40.460  1.00 37.06 ? 539  THR A CA    1 
ATOM   1924 C C     . THR A 1 246 ? 18.194  79.750  39.281  1.00 35.10 ? 539  THR A C     1 
ATOM   1925 O O     . THR A 1 246 ? 18.510  80.498  38.357  1.00 33.39 ? 539  THR A O     1 
ATOM   1926 C CB    . THR A 1 246 ? 20.100  78.372  40.207  1.00 37.34 ? 539  THR A CB    1 
ATOM   1927 O OG1   . THR A 1 246 ? 19.361  77.150  40.203  1.00 36.21 ? 539  THR A OG1   1 
ATOM   1928 C CG2   . THR A 1 246 ? 21.207  78.288  41.240  1.00 39.74 ? 539  THR A CG2   1 
ATOM   1929 N N     . LYS A 1 247 ? 17.039  79.064  39.331  1.00 34.51 ? 540  LYS A N     1 
ATOM   1930 C CA    . LYS A 1 247 ? 15.958  79.257  38.369  1.00 33.80 ? 540  LYS A CA    1 
ATOM   1931 C C     . LYS A 1 247 ? 15.588  80.737  38.323  1.00 31.55 ? 540  LYS A C     1 
ATOM   1932 O O     . LYS A 1 247 ? 15.719  81.371  37.285  1.00 35.99 ? 540  LYS A O     1 
ATOM   1933 C CB    . LYS A 1 247 ? 14.769  78.362  38.745  1.00 35.29 ? 540  LYS A CB    1 
ATOM   1934 C CG    . LYS A 1 247 ? 13.518  78.463  37.877  1.00 37.20 ? 540  LYS A CG    1 
ATOM   1935 C CD    . LYS A 1 247 ? 13.741  78.107  36.437  1.00 35.26 ? 540  LYS A CD    1 
ATOM   1936 C CE    . LYS A 1 247 ? 12.448  77.789  35.709  1.00 36.10 ? 540  LYS A CE    1 
ATOM   1937 N NZ    . LYS A 1 247 ? 12.713  77.298  34.340  1.00 33.64 ? 540  LYS A NZ    1 
ATOM   1938 N N     . LEU A 1 248 ? 15.173  81.303  39.461  1.00 31.09 ? 541  LEU A N     1 
ATOM   1939 C CA    . LEU A 1 248 ? 14.653  82.660  39.491  1.00 32.58 ? 541  LEU A CA    1 
ATOM   1940 C C     . LEU A 1 248 ? 15.735  83.706  39.213  1.00 35.68 ? 541  LEU A C     1 
ATOM   1941 O O     . LEU A 1 248 ? 15.446  84.753  38.625  1.00 35.39 ? 541  LEU A O     1 
ATOM   1942 C CB    . LEU A 1 248 ? 13.978  82.909  40.842  1.00 34.91 ? 541  LEU A CB    1 
ATOM   1943 C CG    . LEU A 1 248 ? 12.859  81.936  41.221  1.00 36.95 ? 541  LEU A CG    1 
ATOM   1944 C CD1   . LEU A 1 248 ? 12.007  82.494  42.349  1.00 38.77 ? 541  LEU A CD1   1 
ATOM   1945 C CD2   . LEU A 1 248 ? 11.995  81.580  40.030  1.00 37.50 ? 541  LEU A CD2   1 
ATOM   1946 N N     . LYS A 1 249 ? 16.970  83.452  39.660  1.00 34.88 ? 542  LYS A N     1 
ATOM   1947 C CA    . LYS A 1 249 ? 18.061  84.402  39.489  1.00 34.74 ? 542  LYS A CA    1 
ATOM   1948 C C     . LYS A 1 249 ? 18.495  84.464  38.023  1.00 32.85 ? 542  LYS A C     1 
ATOM   1949 O O     . LYS A 1 249 ? 18.625  85.547  37.459  1.00 35.78 ? 542  LYS A O     1 
ATOM   1950 C CB    . LYS A 1 249 ? 19.242  83.987  40.377  1.00 41.13 ? 542  LYS A CB    1 
ATOM   1951 C CG    . LYS A 1 249 ? 20.529  84.791  40.221  1.00 42.24 ? 542  LYS A CG    1 
ATOM   1952 C CD    . LYS A 1 249 ? 21.737  84.123  40.880  1.00 46.07 ? 542  LYS A CD    1 
ATOM   1953 C CE    . LYS A 1 249 ? 23.046  84.834  40.598  1.00 45.88 ? 542  LYS A CE    1 
ATOM   1954 N NZ    . LYS A 1 249 ? 22.955  86.251  41.005  1.00 46.55 ? 542  LYS A NZ    1 
ATOM   1955 N N     . SER A 1 250 ? 18.715  83.291  37.424  1.00 31.13 ? 543  SER A N     1 
ATOM   1956 C CA    . SER A 1 250 ? 19.231  83.188  36.074  1.00 34.92 ? 543  SER A CA    1 
ATOM   1957 C C     . SER A 1 250 ? 18.180  83.575  35.036  1.00 33.34 ? 543  SER A C     1 
ATOM   1958 O O     . SER A 1 250 ? 18.547  83.952  33.933  1.00 32.40 ? 543  SER A O     1 
ATOM   1959 C CB    . SER A 1 250 ? 19.756  81.801  35.794  1.00 38.20 ? 543  SER A CB    1 
ATOM   1960 O OG    . SER A 1 250 ? 18.683  80.875  35.626  1.00 39.71 ? 543  SER A OG    1 
ATOM   1961 N N     . THR A 1 251 ? 16.887  83.423  35.359  1.00 33.35 ? 544  THR A N     1 
ATOM   1962 C CA    . THR A 1 251 ? 15.833  83.654  34.383  1.00 32.15 ? 544  THR A CA    1 
ATOM   1963 C C     . THR A 1 251 ? 15.193  85.027  34.588  1.00 32.31 ? 544  THR A C     1 
ATOM   1964 O O     . THR A 1 251 ? 14.743  85.635  33.623  1.00 31.08 ? 544  THR A O     1 
ATOM   1965 C CB    . THR A 1 251 ? 14.798  82.521  34.369  1.00 31.25 ? 544  THR A CB    1 
ATOM   1966 O OG1   . THR A 1 251 ? 15.486  81.286  34.140  1.00 28.62 ? 544  THR A OG1   1 
ATOM   1967 C CG2   . THR A 1 251 ? 13.740  82.726  33.303  1.00 29.73 ? 544  THR A CG2   1 
ATOM   1968 N N     . TYR A 1 252 ? 15.173  85.543  35.824  1.00 32.83 ? 545  TYR A N     1 
ATOM   1969 C CA    . TYR A 1 252 ? 14.392  86.737  36.106  1.00 31.11 ? 545  TYR A CA    1 
ATOM   1970 C C     . TYR A 1 252 ? 15.243  87.841  36.750  1.00 34.96 ? 545  TYR A C     1 
ATOM   1971 O O     . TYR A 1 252 ? 15.327  88.945  36.205  1.00 34.72 ? 545  TYR A O     1 
ATOM   1972 C CB    . TYR A 1 252 ? 13.145  86.326  36.888  1.00 31.04 ? 545  TYR A CB    1 
ATOM   1973 C CG    . TYR A 1 252 ? 12.259  85.335  36.159  1.00 30.06 ? 545  TYR A CG    1 
ATOM   1974 C CD1   . TYR A 1 252 ? 11.421  85.732  35.124  1.00 30.38 ? 545  TYR A CD1   1 
ATOM   1975 C CD2   . TYR A 1 252 ? 12.291  83.984  36.463  1.00 30.18 ? 545  TYR A CD2   1 
ATOM   1976 C CE1   . TYR A 1 252 ? 10.627  84.827  34.431  1.00 28.76 ? 545  TYR A CE1   1 
ATOM   1977 C CE2   . TYR A 1 252 ? 11.496  83.062  35.789  1.00 31.83 ? 545  TYR A CE2   1 
ATOM   1978 C CZ    . TYR A 1 252 ? 10.652  83.486  34.774  1.00 30.69 ? 545  TYR A CZ    1 
ATOM   1979 O OH    . TYR A 1 252 ? 9.869   82.570  34.107  1.00 31.39 ? 545  TYR A OH    1 
ATOM   1980 N N     . ILE A 1 253 ? 15.874  87.562  37.898  1.00 34.47 ? 546  ILE A N     1 
ATOM   1981 C CA    . ILE A 1 253 ? 16.487  88.608  38.711  1.00 35.42 ? 546  ILE A CA    1 
ATOM   1982 C C     . ILE A 1 253 ? 17.626  89.279  37.937  1.00 33.66 ? 546  ILE A C     1 
ATOM   1983 O O     . ILE A 1 253 ? 17.684  90.505  37.903  1.00 36.57 ? 546  ILE A O     1 
ATOM   1984 C CB    . ILE A 1 253 ? 16.964  88.061  40.074  1.00 36.18 ? 546  ILE A CB    1 
ATOM   1985 C CG1   . ILE A 1 253 ? 15.794  87.475  40.874  1.00 36.92 ? 546  ILE A CG1   1 
ATOM   1986 C CG2   . ILE A 1 253 ? 17.712  89.142  40.852  1.00 35.63 ? 546  ILE A CG2   1 
ATOM   1987 C CD1   . ILE A 1 253 ? 16.186  86.747  42.143  1.00 37.66 ? 546  ILE A CD1   1 
ATOM   1988 N N     . ASP A 1 254 ? 18.468  88.475  37.282  1.00 33.53 ? 547  ASP A N     1 
ATOM   1989 C CA    . ASP A 1 254 ? 19.657  88.953  36.586  1.00 38.39 ? 547  ASP A CA    1 
ATOM   1990 C C     . ASP A 1 254 ? 19.348  89.467  35.174  1.00 41.82 ? 547  ASP A C     1 
ATOM   1991 O O     . ASP A 1 254 ? 19.848  90.527  34.804  1.00 42.33 ? 547  ASP A O     1 
ATOM   1992 C CB    . ASP A 1 254 ? 20.744  87.871  36.532  1.00 39.86 ? 547  ASP A CB    1 
ATOM   1993 C CG    . ASP A 1 254 ? 21.452  87.603  37.856  1.00 40.36 ? 547  ASP A CG    1 
ATOM   1994 O OD1   . ASP A 1 254 ? 21.187  88.333  38.828  1.00 39.48 ? 547  ASP A OD1   1 
ATOM   1995 O OD2   . ASP A 1 254 ? 22.246  86.651  37.903  1.00 41.85 ? 547  ASP A OD2   1 
ATOM   1996 N N     . PRO A 1 255 ? 18.626  88.726  34.291  1.00 40.42 ? 548  PRO A N     1 
ATOM   1997 C CA    . PRO A 1 255 ? 18.351  89.216  32.935  1.00 41.41 ? 548  PRO A CA    1 
ATOM   1998 C C     . PRO A 1 255 ? 17.567  90.525  32.808  1.00 39.99 ? 548  PRO A C     1 
ATOM   1999 O O     . PRO A 1 255 ? 17.862  91.335  31.936  1.00 40.31 ? 548  PRO A O     1 
ATOM   2000 C CB    . PRO A 1 255 ? 17.527  88.076  32.318  1.00 43.36 ? 548  PRO A CB    1 
ATOM   2001 C CG    . PRO A 1 255 ? 18.026  86.847  33.039  1.00 44.94 ? 548  PRO A CG    1 
ATOM   2002 C CD    . PRO A 1 255 ? 18.198  87.328  34.467  1.00 43.20 ? 548  PRO A CD    1 
ATOM   2003 N N     . LEU A 1 256 ? 16.574  90.731  33.676  1.00 38.55 ? 549  LEU A N     1 
ATOM   2004 C CA    . LEU A 1 256 ? 15.587  91.782  33.486  1.00 38.24 ? 549  LEU A CA    1 
ATOM   2005 C C     . LEU A 1 256 ? 16.211  93.175  33.558  1.00 42.15 ? 549  LEU A C     1 
ATOM   2006 O O     . LEU A 1 256 ? 15.876  94.043  32.748  1.00 41.22 ? 549  LEU A O     1 
ATOM   2007 C CB    . LEU A 1 256 ? 14.476  91.619  34.524  1.00 38.48 ? 549  LEU A CB    1 
ATOM   2008 C CG    . LEU A 1 256 ? 13.498  90.473  34.265  1.00 42.39 ? 549  LEU A CG    1 
ATOM   2009 C CD1   . LEU A 1 256 ? 12.461  90.384  35.370  1.00 42.05 ? 549  LEU A CD1   1 
ATOM   2010 C CD2   . LEU A 1 256 ? 12.810  90.627  32.915  1.00 44.55 ? 549  LEU A CD2   1 
ATOM   2011 N N     . PRO A 1 257 ? 17.107  93.474  34.525  1.00 46.12 ? 550  PRO A N     1 
ATOM   2012 C CA    . PRO A 1 257 ? 17.691  94.814  34.618  1.00 47.58 ? 550  PRO A CA    1 
ATOM   2013 C C     . PRO A 1 257 ? 18.486  95.206  33.375  1.00 44.19 ? 550  PRO A C     1 
ATOM   2014 O O     . PRO A 1 257 ? 18.533  96.378  33.025  1.00 47.18 ? 550  PRO A O     1 
ATOM   2015 C CB    . PRO A 1 257 ? 18.595  94.746  35.860  1.00 47.09 ? 550  PRO A CB    1 
ATOM   2016 C CG    . PRO A 1 257 ? 18.039  93.584  36.656  1.00 47.73 ? 550  PRO A CG    1 
ATOM   2017 C CD    . PRO A 1 257 ? 17.570  92.591  35.609  1.00 47.27 ? 550  PRO A CD    1 
ATOM   2018 N N     . ASP A 1 258 ? 19.055  94.217  32.680  1.00 40.31 ? 551  ASP A N     1 
ATOM   2019 C CA    . ASP A 1 258 ? 19.881  94.483  31.514  1.00 42.43 ? 551  ASP A CA    1 
ATOM   2020 C C     . ASP A 1 258 ? 19.042  94.731  30.260  1.00 43.41 ? 551  ASP A C     1 
ATOM   2021 O O     . ASP A 1 258 ? 19.612  94.982  29.202  1.00 44.46 ? 551  ASP A O     1 
ATOM   2022 C CB    . ASP A 1 258 ? 20.871  93.335  31.302  1.00 46.02 ? 551  ASP A CB    1 
ATOM   2023 C CG    . ASP A 1 258 ? 21.920  93.246  32.401  1.00 46.78 ? 551  ASP A CG    1 
ATOM   2024 O OD1   . ASP A 1 258 ? 22.109  94.252  33.105  1.00 45.79 ? 551  ASP A OD1   1 
ATOM   2025 O OD2   . ASP A 1 258 ? 22.516  92.164  32.563  1.00 50.53 ? 551  ASP A OD2   1 
ATOM   2026 N N     . LEU A 1 259 ? 17.704  94.681  30.375  1.00 40.22 ? 552  LEU A N     1 
ATOM   2027 C CA    . LEU A 1 259 ? 16.815  94.810  29.231  1.00 38.50 ? 552  LEU A CA    1 
ATOM   2028 C C     . LEU A 1 259 ? 16.084  96.150  29.266  1.00 38.69 ? 552  LEU A C     1 
ATOM   2029 O O     . LEU A 1 259 ? 15.163  96.356  28.483  1.00 36.55 ? 552  LEU A O     1 
ATOM   2030 C CB    . LEU A 1 259 ? 15.802  93.656  29.241  1.00 37.02 ? 552  LEU A CB    1 
ATOM   2031 C CG    . LEU A 1 259 ? 16.368  92.245  29.086  1.00 34.53 ? 552  LEU A CG    1 
ATOM   2032 C CD1   . LEU A 1 259 ? 15.254  91.218  29.144  1.00 34.12 ? 552  LEU A CD1   1 
ATOM   2033 C CD2   . LEU A 1 259 ? 17.167  92.101  27.796  1.00 35.89 ? 552  LEU A CD2   1 
ATOM   2034 N N     . ILE A 1 260 ? 16.498  97.060  30.161  1.00 37.53 ? 553  ILE A N     1 
ATOM   2035 C CA    . ILE A 1 260 ? 15.866  98.367  30.233  1.00 38.02 ? 553  ILE A CA    1 
ATOM   2036 C C     . ILE A 1 260 ? 16.255  99.155  28.981  1.00 37.50 ? 553  ILE A C     1 
ATOM   2037 O O     . ILE A 1 260 ? 17.404  99.119  28.555  1.00 35.07 ? 553  ILE A O     1 
ATOM   2038 C CB    . ILE A 1 260 ? 16.242  99.110  31.532  1.00 40.13 ? 553  ILE A CB    1 
ATOM   2039 C CG1   . ILE A 1 260 ? 15.838  98.323  32.784  1.00 41.39 ? 553  ILE A CG1   1 
ATOM   2040 C CG2   . ILE A 1 260 ? 15.654  100.513 31.535  1.00 37.57 ? 553  ILE A CG2   1 
ATOM   2041 C CD1   . ILE A 1 260 ? 14.358  98.045  32.879  1.00 42.60 ? 553  ILE A CD1   1 
ATOM   2042 N N     . HIS A 1 261 ? 15.275  99.837  28.380  1.00 38.41 ? 554  HIS A N     1 
ATOM   2043 C CA    . HIS A 1 261 ? 15.478  100.472 27.092  1.00 38.54 ? 554  HIS A CA    1 
ATOM   2044 C C     . HIS A 1 261 ? 16.004  101.894 27.303  1.00 36.95 ? 554  HIS A C     1 
ATOM   2045 O O     . HIS A 1 261 ? 15.424  102.658 28.071  1.00 32.55 ? 554  HIS A O     1 
ATOM   2046 C CB    . HIS A 1 261 ? 14.189  100.433 26.258  1.00 37.54 ? 554  HIS A CB    1 
ATOM   2047 C CG    . HIS A 1 261 ? 14.371  100.816 24.818  1.00 39.94 ? 554  HIS A CG    1 
ATOM   2048 N ND1   . HIS A 1 261 ? 14.432  102.115 24.375  1.00 41.05 ? 554  HIS A ND1   1 
ATOM   2049 C CD2   . HIS A 1 261 ? 14.495  100.021 23.715  1.00 41.88 ? 554  HIS A CD2   1 
ATOM   2050 C CE1   . HIS A 1 261 ? 14.608  102.122 23.054  1.00 43.63 ? 554  HIS A CE1   1 
ATOM   2051 N NE2   . HIS A 1 261 ? 14.642  100.831 22.621  1.00 42.00 ? 554  HIS A NE2   1 
ATOM   2052 N N     . PRO A 1 262 ? 17.116  102.283 26.624  1.00 42.50 ? 555  PRO A N     1 
ATOM   2053 C CA    . PRO A 1 262 ? 17.733  103.597 26.820  1.00 44.09 ? 555  PRO A CA    1 
ATOM   2054 C C     . PRO A 1 262 ? 16.800  104.767 26.526  1.00 45.27 ? 555  PRO A C     1 
ATOM   2055 O O     . PRO A 1 262 ? 16.924  105.819 27.139  1.00 50.80 ? 555  PRO A O     1 
ATOM   2056 C CB    . PRO A 1 262 ? 18.932  103.621 25.855  1.00 44.11 ? 555  PRO A CB    1 
ATOM   2057 C CG    . PRO A 1 262 ? 18.659  102.513 24.864  1.00 44.62 ? 555  PRO A CG    1 
ATOM   2058 C CD    . PRO A 1 262 ? 17.854  101.483 25.634  1.00 42.17 ? 555  PRO A CD    1 
ATOM   2059 N N     . ARG A 1 263 ? 15.855  104.586 25.604  1.00 42.97 ? 556  ARG A N     1 
ATOM   2060 C CA    . ARG A 1 263 ? 15.015  105.695 25.187  1.00 45.84 ? 556  ARG A CA    1 
ATOM   2061 C C     . ARG A 1 263 ? 13.839  105.873 26.147  1.00 43.55 ? 556  ARG A C     1 
ATOM   2062 O O     . ARG A 1 263 ? 13.375  106.990 26.339  1.00 44.40 ? 556  ARG A O     1 
ATOM   2063 C CB    . ARG A 1 263 ? 14.534  105.486 23.749  1.00 48.84 ? 556  ARG A CB    1 
ATOM   2064 C CG    . ARG A 1 263 ? 13.899  106.722 23.131  1.00 53.59 ? 556  ARG A CG    1 
ATOM   2065 C CD    . ARG A 1 263 ? 13.271  106.400 21.794  1.00 58.71 ? 556  ARG A CD    1 
ATOM   2066 N NE    . ARG A 1 263 ? 12.973  107.602 21.031  1.00 63.10 ? 556  ARG A NE    1 
ATOM   2067 C CZ    . ARG A 1 263 ? 13.186  107.740 19.728  1.00 62.09 ? 556  ARG A CZ    1 
ATOM   2068 N NH1   . ARG A 1 263 ? 12.702  108.797 19.100  1.00 64.49 ? 556  ARG A NH1   1 
ATOM   2069 N NH2   . ARG A 1 263 ? 13.846  106.808 19.056  1.00 61.53 ? 556  ARG A NH2   1 
ATOM   2070 N N     . THR A 1 264 ? 13.341  104.775 26.729  1.00 38.36 ? 557  THR A N     1 
ATOM   2071 C CA    . THR A 1 264 ? 12.095  104.811 27.472  1.00 36.87 ? 557  THR A CA    1 
ATOM   2072 C C     . THR A 1 264 ? 12.341  104.732 28.972  1.00 35.74 ? 557  THR A C     1 
ATOM   2073 O O     . THR A 1 264 ? 11.467  105.104 29.746  1.00 36.25 ? 557  THR A O     1 
ATOM   2074 C CB    . THR A 1 264 ? 11.177  103.644 27.077  1.00 36.91 ? 557  THR A CB    1 
ATOM   2075 O OG1   . THR A 1 264 ? 11.800  102.402 27.429  1.00 32.42 ? 557  THR A OG1   1 
ATOM   2076 C CG2   . THR A 1 264 ? 10.851  103.661 25.601  1.00 35.80 ? 557  THR A CG2   1 
ATOM   2077 N N     . GLY A 1 265 ? 13.477  104.153 29.364  1.00 35.66 ? 558  GLY A N     1 
ATOM   2078 C CA    . GLY A 1 265 ? 13.728  103.826 30.757  1.00 37.63 ? 558  GLY A CA    1 
ATOM   2079 C C     . GLY A 1 265 ? 12.849  102.680 31.269  1.00 40.47 ? 558  GLY A C     1 
ATOM   2080 O O     . GLY A 1 265 ? 12.761  102.481 32.478  1.00 42.74 ? 558  GLY A O     1 
ATOM   2081 N N     . ARG A 1 266 ? 12.226  101.913 30.359  1.00 39.66 ? 559  ARG A N     1 
ATOM   2082 C CA    . ARG A 1 266 ? 11.281  100.870 30.737  1.00 37.75 ? 559  ARG A CA    1 
ATOM   2083 C C     . ARG A 1 266 ? 11.651  99.545  30.071  1.00 35.25 ? 559  ARG A C     1 
ATOM   2084 O O     . ARG A 1 266 ? 12.537  99.494  29.216  1.00 36.20 ? 559  ARG A O     1 
ATOM   2085 C CB    . ARG A 1 266 ? 9.857   101.349 30.429  1.00 38.05 ? 559  ARG A CB    1 
ATOM   2086 C CG    . ARG A 1 266 ? 9.410   102.473 31.359  1.00 41.47 ? 559  ARG A CG    1 
ATOM   2087 C CD    . ARG A 1 266 ? 8.152   103.217 30.954  1.00 41.42 ? 559  ARG A CD    1 
ATOM   2088 N NE    . ARG A 1 266 ? 6.950   102.414 31.139  1.00 44.17 ? 559  ARG A NE    1 
ATOM   2089 C CZ    . ARG A 1 266 ? 6.002   102.646 32.041  1.00 41.65 ? 559  ARG A CZ    1 
ATOM   2090 N NH1   . ARG A 1 266 ? 6.186   103.532 33.005  1.00 39.33 ? 559  ARG A NH1   1 
ATOM   2091 N NH2   . ARG A 1 266 ? 4.868   101.977 31.974  1.00 40.42 ? 559  ARG A NH2   1 
ATOM   2092 N N     . LEU A 1 267 ? 10.975  98.474  30.517  1.00 32.34 ? 560  LEU A N     1 
ATOM   2093 C CA    . LEU A 1 267 ? 11.144  97.119  30.010  1.00 33.91 ? 560  LEU A CA    1 
ATOM   2094 C C     . LEU A 1 267 ? 10.000  96.783  29.040  1.00 32.57 ? 560  LEU A C     1 
ATOM   2095 O O     . LEU A 1 267 ? 8.818   96.975  29.355  1.00 31.75 ? 560  LEU A O     1 
ATOM   2096 C CB    . LEU A 1 267 ? 11.183  96.160  31.214  1.00 33.73 ? 560  LEU A CB    1 
ATOM   2097 C CG    . LEU A 1 267 ? 11.272  94.662  30.906  1.00 33.28 ? 560  LEU A CG    1 
ATOM   2098 C CD1   . LEU A 1 267 ? 12.655  94.282  30.415  1.00 36.48 ? 560  LEU A CD1   1 
ATOM   2099 C CD2   . LEU A 1 267 ? 10.939  93.841  32.134  1.00 37.54 ? 560  LEU A CD2   1 
ATOM   2100 N N     . HIS A 1 268 ? 10.359  96.235  27.864  1.00 31.78 ? 561  HIS A N     1 
ATOM   2101 C CA    . HIS A 1 268 ? 9.419   96.029  26.764  1.00 29.98 ? 561  HIS A CA    1 
ATOM   2102 C C     . HIS A 1 268 ? 9.358   94.549  26.406  1.00 31.33 ? 561  HIS A C     1 
ATOM   2103 O O     . HIS A 1 268 ? 10.382  93.953  26.076  1.00 37.62 ? 561  HIS A O     1 
ATOM   2104 C CB    . HIS A 1 268 ? 9.815   96.869  25.542  1.00 29.90 ? 561  HIS A CB    1 
ATOM   2105 C CG    . HIS A 1 268 ? 9.782   98.339  25.817  1.00 28.76 ? 561  HIS A CG    1 
ATOM   2106 N ND1   . HIS A 1 268 ? 8.675   99.126  25.619  1.00 29.49 ? 561  HIS A ND1   1 
ATOM   2107 C CD2   . HIS A 1 268 ? 10.722  99.118  26.419  1.00 29.16 ? 561  HIS A CD2   1 
ATOM   2108 C CE1   . HIS A 1 268 ? 8.940   100.362 26.043  1.00 30.82 ? 561  HIS A CE1   1 
ATOM   2109 N NE2   . HIS A 1 268 ? 10.198  100.380 26.542  1.00 29.01 ? 561  HIS A NE2   1 
ATOM   2110 N N     . THR A 1 269 ? 8.162   93.964  26.538  1.00 29.11 ? 562  THR A N     1 
ATOM   2111 C CA    . THR A 1 269 ? 7.904   92.601  26.110  1.00 29.82 ? 562  THR A CA    1 
ATOM   2112 C C     . THR A 1 269 ? 7.225   92.641  24.744  1.00 29.04 ? 562  THR A C     1 
ATOM   2113 O O     . THR A 1 269 ? 6.956   93.714  24.201  1.00 29.73 ? 562  THR A O     1 
ATOM   2114 C CB    . THR A 1 269 ? 7.041   91.829  27.129  1.00 30.43 ? 562  THR A CB    1 
ATOM   2115 O OG1   . THR A 1 269 ? 7.031   90.431  26.801  1.00 25.29 ? 562  THR A OG1   1 
ATOM   2116 C CG2   . THR A 1 269 ? 5.623   92.357  27.195  1.00 27.43 ? 562  THR A CG2   1 
ATOM   2117 N N     . ARG A 1 270 ? 6.972   91.448  24.209  1.00 25.95 ? 563  ARG A N     1 
ATOM   2118 C CA    . ARG A 1 270 ? 6.245   91.259  22.970  1.00 26.50 ? 563  ARG A CA    1 
ATOM   2119 C C     . ARG A 1 270 ? 5.037   90.395  23.294  1.00 25.91 ? 563  ARG A C     1 
ATOM   2120 O O     . ARG A 1 270 ? 5.201   89.372  23.955  1.00 24.96 ? 563  ARG A O     1 
ATOM   2121 C CB    . ARG A 1 270 ? 7.128   90.558  21.929  1.00 25.79 ? 563  ARG A CB    1 
ATOM   2122 C CG    . ARG A 1 270 ? 8.411   91.309  21.595  1.00 26.88 ? 563  ARG A CG    1 
ATOM   2123 C CD    . ARG A 1 270 ? 9.285   90.517  20.645  1.00 30.34 ? 563  ARG A CD    1 
ATOM   2124 N NE    . ARG A 1 270 ? 8.641   90.312  19.366  1.00 28.08 ? 563  ARG A NE    1 
ATOM   2125 C CZ    . ARG A 1 270 ? 9.011   89.413  18.465  1.00 32.11 ? 563  ARG A CZ    1 
ATOM   2126 N NH1   . ARG A 1 270 ? 9.869   88.454  18.773  1.00 30.63 ? 563  ARG A NH1   1 
ATOM   2127 N NH2   . ARG A 1 270 ? 8.479   89.471  17.259  1.00 32.60 ? 563  ARG A NH2   1 
ATOM   2128 N N     . PHE A 1 271 ? 3.852   90.837  22.854  1.00 25.49 ? 564  PHE A N     1 
ATOM   2129 C CA    . PHE A 1 271 ? 2.613   90.089  22.998  1.00 25.67 ? 564  PHE A CA    1 
ATOM   2130 C C     . PHE A 1 271 ? 2.258   89.497  21.642  1.00 26.71 ? 564  PHE A C     1 
ATOM   2131 O O     . PHE A 1 271 ? 1.773   90.200  20.748  1.00 28.00 ? 564  PHE A O     1 
ATOM   2132 C CB    . PHE A 1 271 ? 1.504   90.995  23.537  1.00 26.13 ? 564  PHE A CB    1 
ATOM   2133 C CG    . PHE A 1 271 ? 1.648   91.317  25.001  1.00 27.40 ? 564  PHE A CG    1 
ATOM   2134 C CD1   . PHE A 1 271 ? 1.472   90.327  25.956  1.00 27.25 ? 564  PHE A CD1   1 
ATOM   2135 C CD2   . PHE A 1 271 ? 2.037   92.588  25.419  1.00 28.64 ? 564  PHE A CD2   1 
ATOM   2136 C CE1   . PHE A 1 271 ? 1.654   90.609  27.306  1.00 29.62 ? 564  PHE A CE1   1 
ATOM   2137 C CE2   . PHE A 1 271 ? 2.204   92.869  26.770  1.00 28.63 ? 564  PHE A CE2   1 
ATOM   2138 C CZ    . PHE A 1 271 ? 2.031   91.875  27.710  1.00 28.65 ? 564  PHE A CZ    1 
ATOM   2139 N N     . ASN A 1 272 ? 2.548   88.204  21.513  1.00 24.90 ? 565  ASN A N     1 
ATOM   2140 C CA    . ASN A 1 272 ? 2.379   87.450  20.282  1.00 24.25 ? 565  ASN A CA    1 
ATOM   2141 C C     . ASN A 1 272 ? 0.913   87.029  20.119  1.00 23.61 ? 565  ASN A C     1 
ATOM   2142 O O     . ASN A 1 272 ? 0.347   86.330  20.967  1.00 22.14 ? 565  ASN A O     1 
ATOM   2143 C CB    . ASN A 1 272 ? 3.308   86.235  20.291  1.00 23.82 ? 565  ASN A CB    1 
ATOM   2144 C CG    . ASN A 1 272 ? 4.730   86.596  20.654  1.00 24.21 ? 565  ASN A CG    1 
ATOM   2145 O OD1   . ASN A 1 272 ? 5.384   87.345  19.935  1.00 24.46 ? 565  ASN A OD1   1 
ATOM   2146 N ND2   . ASN A 1 272 ? 5.210   86.096  21.780  1.00 22.31 ? 565  ASN A ND2   1 
ATOM   2147 N N     . GLN A 1 273 ? 0.316   87.427  18.992  1.00 23.36 ? 566  GLN A N     1 
ATOM   2148 C CA    . GLN A 1 273 ? -1.119  87.316  18.797  1.00 24.33 ? 566  GLN A CA    1 
ATOM   2149 C C     . GLN A 1 273 ? -1.464  86.051  17.997  1.00 24.98 ? 566  GLN A C     1 
ATOM   2150 O O     . GLN A 1 273 ? -2.628  85.686  17.955  1.00 25.07 ? 566  GLN A O     1 
ATOM   2151 C CB    . GLN A 1 273 ? -1.607  88.603  18.129  1.00 25.83 ? 566  GLN A CB    1 
ATOM   2152 C CG    . GLN A 1 273 ? -3.103  88.852  18.227  1.00 25.86 ? 566  GLN A CG    1 
ATOM   2153 C CD    . GLN A 1 273 ? -3.561  90.128  17.550  1.00 25.82 ? 566  GLN A CD    1 
ATOM   2154 O OE1   . GLN A 1 273 ? -2.766  91.012  17.213  1.00 23.86 ? 566  GLN A OE1   1 
ATOM   2155 N NE2   . GLN A 1 273 ? -4.876  90.252  17.397  1.00 22.34 ? 566  GLN A NE2   1 
ATOM   2156 N N     . THR A 1 274 ? -0.478  85.360  17.378  1.00 23.07 ? 567  THR A N     1 
ATOM   2157 C CA    . THR A 1 274 ? -0.782  84.169  16.582  1.00 23.22 ? 567  THR A CA    1 
ATOM   2158 C C     . THR A 1 274 ? 0.179   83.037  16.940  1.00 23.77 ? 567  THR A C     1 
ATOM   2159 O O     . THR A 1 274 ? 0.838   82.468  16.059  1.00 24.44 ? 567  THR A O     1 
ATOM   2160 C CB    . THR A 1 274 ? -0.723  84.434  15.069  1.00 22.70 ? 567  THR A CB    1 
ATOM   2161 O OG1   . THR A 1 274 ? 0.620   84.655  14.659  1.00 23.20 ? 567  THR A OG1   1 
ATOM   2162 C CG2   . THR A 1 274 ? -1.537  85.630  14.624  1.00 24.02 ? 567  THR A CG2   1 
ATOM   2163 N N     . ALA A 1 275 ? 0.226   82.688  18.232  1.00 23.25 ? 568  ALA A N     1 
ATOM   2164 C CA    . ALA A 1 275 ? 1.295   81.842  18.732  1.00 25.38 ? 568  ALA A CA    1 
ATOM   2165 C C     . ALA A 1 275 ? 0.780   80.598  19.444  1.00 24.24 ? 568  ALA A C     1 
ATOM   2166 O O     . ALA A 1 275 ? 1.566   79.687  19.701  1.00 26.44 ? 568  ALA A O     1 
ATOM   2167 C CB    . ALA A 1 275 ? 2.208   82.649  19.635  1.00 25.29 ? 568  ALA A CB    1 
ATOM   2168 N N     . THR A 1 276 ? -0.511  80.544  19.770  1.00 24.02 ? 569  THR A N     1 
ATOM   2169 C CA    . THR A 1 276 ? -1.031  79.471  20.604  1.00 23.57 ? 569  THR A CA    1 
ATOM   2170 C C     . THR A 1 276 ? -2.096  78.697  19.838  1.00 24.00 ? 569  THR A C     1 
ATOM   2171 O O     . THR A 1 276 ? -2.671  79.210  18.879  1.00 25.14 ? 569  THR A O     1 
ATOM   2172 C CB    . THR A 1 276 ? -1.627  79.996  21.917  1.00 25.05 ? 569  THR A CB    1 
ATOM   2173 O OG1   . THR A 1 276 ? -2.865  80.666  21.644  1.00 26.94 ? 569  THR A OG1   1 
ATOM   2174 C CG2   . THR A 1 276 ? -0.682  80.929  22.643  1.00 24.11 ? 569  THR A CG2   1 
ATOM   2175 N N     . ALA A 1 277 ? -2.405  77.490  20.333  1.00 23.50 ? 570  ALA A N     1 
ATOM   2176 C CA    . ALA A 1 277 ? -3.388  76.622  19.709  1.00 25.38 ? 570  ALA A CA    1 
ATOM   2177 C C     . ALA A 1 277 ? -4.785  76.883  20.267  1.00 26.95 ? 570  ALA A C     1 
ATOM   2178 O O     . ALA A 1 277 ? -5.746  76.296  19.787  1.00 27.54 ? 570  ALA A O     1 
ATOM   2179 C CB    . ALA A 1 277 ? -2.995  75.169  19.898  1.00 26.41 ? 570  ALA A CB    1 
ATOM   2180 N N     . THR A 1 278 ? -4.890  77.724  21.299  1.00 28.37 ? 571  THR A N     1 
ATOM   2181 C CA    . THR A 1 278 ? -6.127  77.896  22.044  1.00 30.03 ? 571  THR A CA    1 
ATOM   2182 C C     . THR A 1 278 ? -6.743  79.273  21.803  1.00 30.08 ? 571  THR A C     1 
ATOM   2183 O O     . THR A 1 278 ? -7.923  79.467  22.096  1.00 29.55 ? 571  THR A O     1 
ATOM   2184 C CB    . THR A 1 278 ? -5.876  77.729  23.541  1.00 29.38 ? 571  THR A CB    1 
ATOM   2185 O OG1   . THR A 1 278 ? -4.927  78.715  23.970  1.00 28.65 ? 571  THR A OG1   1 
ATOM   2186 C CG2   . THR A 1 278 ? -5.372  76.345  23.884  1.00 32.56 ? 571  THR A CG2   1 
ATOM   2187 N N     . GLY A 1 279 ? -5.939  80.204  21.271  1.00 27.00 ? 572  GLY A N     1 
ATOM   2188 C CA    . GLY A 1 279 ? -6.358  81.584  21.107  1.00 27.47 ? 572  GLY A CA    1 
ATOM   2189 C C     . GLY A 1 279 ? -5.855  82.502  22.224  1.00 25.48 ? 572  GLY A C     1 
ATOM   2190 O O     . GLY A 1 279 ? -6.137  83.689  22.196  1.00 23.79 ? 572  GLY A O     1 
ATOM   2191 N N     . ARG A 1 280 ? -5.100  81.975  23.197  1.00 23.41 ? 573  ARG A N     1 
ATOM   2192 C CA    . ARG A 1 280 ? -4.443  82.825  24.181  1.00 24.86 ? 573  ARG A CA    1 
ATOM   2193 C C     . ARG A 1 280 ? -3.368  83.646  23.480  1.00 21.74 ? 573  ARG A C     1 
ATOM   2194 O O     . ARG A 1 280 ? -2.889  83.242  22.431  1.00 19.86 ? 573  ARG A O     1 
ATOM   2195 C CB    . ARG A 1 280 ? -3.764  82.007  25.288  1.00 25.18 ? 573  ARG A CB    1 
ATOM   2196 C CG    . ARG A 1 280 ? -4.694  81.532  26.392  1.00 25.64 ? 573  ARG A CG    1 
ATOM   2197 C CD    . ARG A 1 280 ? -3.901  80.862  27.497  1.00 26.74 ? 573  ARG A CD    1 
ATOM   2198 N NE    . ARG A 1 280 ? -4.671  80.742  28.726  1.00 24.86 ? 573  ARG A NE    1 
ATOM   2199 C CZ    . ARG A 1 280 ? -4.195  80.287  29.880  1.00 27.89 ? 573  ARG A CZ    1 
ATOM   2200 N NH1   . ARG A 1 280 ? -5.031  80.073  30.889  1.00 25.63 ? 573  ARG A NH1   1 
ATOM   2201 N NH2   . ARG A 1 280 ? -2.897  80.025  30.006  1.00 24.26 ? 573  ARG A NH2   1 
ATOM   2202 N N     . LEU A 1 281 ? -3.007  84.799  24.058  1.00 21.83 ? 574  LEU A N     1 
ATOM   2203 C CA    . LEU A 1 281 ? -1.738  85.439  23.721  1.00 21.39 ? 574  LEU A CA    1 
ATOM   2204 C C     . LEU A 1 281 ? -0.579  84.627  24.321  1.00 23.11 ? 574  LEU A C     1 
ATOM   2205 O O     . LEU A 1 281 ? -0.774  83.826  25.244  1.00 21.63 ? 574  LEU A O     1 
ATOM   2206 C CB    . LEU A 1 281 ? -1.701  86.853  24.305  1.00 20.46 ? 574  LEU A CB    1 
ATOM   2207 C CG    . LEU A 1 281 ? -2.821  87.798  23.885  1.00 20.35 ? 574  LEU A CG    1 
ATOM   2208 C CD1   . LEU A 1 281 ? -2.709  89.116  24.627  1.00 21.10 ? 574  LEU A CD1   1 
ATOM   2209 C CD2   . LEU A 1 281 ? -2.798  88.022  22.381  1.00 19.68 ? 574  LEU A CD2   1 
ATOM   2210 N N     . SER A 1 282 ? 0.636   84.893  23.816  1.00 22.30 ? 575  SER A N     1 
ATOM   2211 C CA    . SER A 1 282 ? 1.868   84.563  24.508  1.00 22.34 ? 575  SER A CA    1 
ATOM   2212 C C     . SER A 1 282 ? 2.668   85.852  24.658  1.00 23.03 ? 575  SER A C     1 
ATOM   2213 O O     . SER A 1 282 ? 2.260   86.895  24.134  1.00 24.55 ? 575  SER A O     1 
ATOM   2214 C CB    . SER A 1 282 ? 2.659   83.487  23.785  1.00 22.98 ? 575  SER A CB    1 
ATOM   2215 O OG    . SER A 1 282 ? 3.355   84.024  22.669  1.00 23.98 ? 575  SER A OG    1 
ATOM   2216 N N     . SER A 1 283 ? 3.726   85.771  25.467  1.00 22.26 ? 576  SER A N     1 
ATOM   2217 C CA    . SER A 1 283 ? 4.646   86.865  25.754  1.00 23.28 ? 576  SER A CA    1 
ATOM   2218 C C     . SER A 1 283 ? 6.069   86.339  25.607  1.00 24.52 ? 576  SER A C     1 
ATOM   2219 O O     . SER A 1 283 ? 6.340   85.193  25.995  1.00 23.77 ? 576  SER A O     1 
ATOM   2220 C CB    . SER A 1 283 ? 4.410   87.434  27.142  1.00 22.65 ? 576  SER A CB    1 
ATOM   2221 O OG    . SER A 1 283 ? 5.438   88.352  27.508  1.00 20.55 ? 576  SER A OG    1 
ATOM   2222 N N     . SER A 1 284 ? 6.946   87.150  24.986  1.00 26.15 ? 577  SER A N     1 
ATOM   2223 C CA    . SER A 1 284 ? 8.340   86.766  24.824  1.00 25.43 ? 577  SER A CA    1 
ATOM   2224 C C     . SER A 1 284 ? 9.256   87.992  24.773  1.00 27.21 ? 577  SER A C     1 
ATOM   2225 O O     . SER A 1 284 ? 8.800   89.130  24.586  1.00 22.31 ? 577  SER A O     1 
ATOM   2226 C CB    . SER A 1 284 ? 8.523   85.887  23.610  1.00 26.36 ? 577  SER A CB    1 
ATOM   2227 O OG    . SER A 1 284 ? 8.144   86.563  22.426  1.00 24.49 ? 577  SER A OG    1 
ATOM   2228 N N     . ASP A 1 285 ? 10.552  87.718  24.993  1.00 26.55 ? 578  ASP A N     1 
ATOM   2229 C CA    . ASP A 1 285 ? 11.633  88.677  24.801  1.00 28.52 ? 578  ASP A CA    1 
ATOM   2230 C C     . ASP A 1 285 ? 11.488  89.916  25.694  1.00 28.55 ? 578  ASP A C     1 
ATOM   2231 O O     . ASP A 1 285 ? 11.559  91.041  25.202  1.00 29.88 ? 578  ASP A O     1 
ATOM   2232 C CB    . ASP A 1 285 ? 11.696  89.038  23.310  1.00 30.80 ? 578  ASP A CB    1 
ATOM   2233 C CG    . ASP A 1 285 ? 11.740  87.813  22.406  1.00 31.72 ? 578  ASP A CG    1 
ATOM   2234 O OD1   . ASP A 1 285 ? 12.671  86.999  22.561  1.00 32.09 ? 578  ASP A OD1   1 
ATOM   2235 O OD2   . ASP A 1 285 ? 10.814  87.650  21.586  1.00 36.18 ? 578  ASP A OD2   1 
ATOM   2236 N N     . PRO A 1 286 ? 11.295  89.808  27.032  1.00 28.32 ? 579  PRO A N     1 
ATOM   2237 C CA    . PRO A 1 286 ? 11.170  88.540  27.756  1.00 28.93 ? 579  PRO A CA    1 
ATOM   2238 C C     . PRO A 1 286 ? 9.713   88.130  27.982  1.00 24.93 ? 579  PRO A C     1 
ATOM   2239 O O     . PRO A 1 286 ? 8.808   88.896  27.690  1.00 27.24 ? 579  PRO A O     1 
ATOM   2240 C CB    . PRO A 1 286 ? 11.796  88.942  29.090  1.00 29.00 ? 579  PRO A CB    1 
ATOM   2241 C CG    . PRO A 1 286 ? 11.198  90.324  29.321  1.00 30.45 ? 579  PRO A CG    1 
ATOM   2242 C CD    . PRO A 1 286 ? 11.158  90.953  27.943  1.00 30.33 ? 579  PRO A CD    1 
ATOM   2243 N N     . ASN A 1 287 ? 9.500   86.952  28.563  1.00 26.67 ? 580  ASN A N     1 
ATOM   2244 C CA    . ASN A 1 287 ? 8.155   86.466  28.856  1.00 26.76 ? 580  ASN A CA    1 
ATOM   2245 C C     . ASN A 1 287 ? 7.660   87.057  30.177  1.00 27.38 ? 580  ASN A C     1 
ATOM   2246 O O     . ASN A 1 287 ? 8.035   86.583  31.244  1.00 29.16 ? 580  ASN A O     1 
ATOM   2247 C CB    . ASN A 1 287 ? 8.112   84.938  28.913  1.00 24.03 ? 580  ASN A CB    1 
ATOM   2248 C CG    . ASN A 1 287 ? 6.710   84.400  29.107  1.00 25.82 ? 580  ASN A CG    1 
ATOM   2249 O OD1   . ASN A 1 287 ? 5.749   85.166  29.229  1.00 23.24 ? 580  ASN A OD1   1 
ATOM   2250 N ND2   . ASN A 1 287 ? 6.587   83.084  29.142  1.00 23.86 ? 580  ASN A ND2   1 
ATOM   2251 N N     . LEU A 1 288 ? 6.777   88.061  30.098  1.00 25.97 ? 581  LEU A N     1 
ATOM   2252 C CA    . LEU A 1 288 ? 6.230   88.701  31.279  1.00 25.92 ? 581  LEU A CA    1 
ATOM   2253 C C     . LEU A 1 288 ? 4.908   88.064  31.719  1.00 26.26 ? 581  LEU A C     1 
ATOM   2254 O O     . LEU A 1 288 ? 4.257   88.576  32.629  1.00 28.82 ? 581  LEU A O     1 
ATOM   2255 C CB    . LEU A 1 288 ? 6.072   90.195  31.000  1.00 27.85 ? 581  LEU A CB    1 
ATOM   2256 C CG    . LEU A 1 288 ? 7.383   90.952  30.752  1.00 29.09 ? 581  LEU A CG    1 
ATOM   2257 C CD1   . LEU A 1 288 ? 7.156   92.451  30.758  1.00 30.59 ? 581  LEU A CD1   1 
ATOM   2258 C CD2   . LEU A 1 288 ? 8.439   90.598  31.776  1.00 30.83 ? 581  LEU A CD2   1 
ATOM   2259 N N     . GLN A 1 289 ? 4.557   86.909  31.142  1.00 26.54 ? 582  GLN A N     1 
ATOM   2260 C CA    . GLN A 1 289 ? 3.451   86.080  31.619  1.00 24.87 ? 582  GLN A CA    1 
ATOM   2261 C C     . GLN A 1 289 ? 3.955   84.862  32.412  1.00 26.71 ? 582  GLN A C     1 
ATOM   2262 O O     . GLN A 1 289 ? 3.181   83.935  32.719  1.00 23.83 ? 582  GLN A O     1 
ATOM   2263 C CB    . GLN A 1 289 ? 2.604   85.614  30.432  1.00 25.71 ? 582  GLN A CB    1 
ATOM   2264 C CG    . GLN A 1 289 ? 1.979   86.755  29.614  1.00 24.83 ? 582  GLN A CG    1 
ATOM   2265 C CD    . GLN A 1 289 ? 1.139   86.251  28.457  1.00 25.90 ? 582  GLN A CD    1 
ATOM   2266 O OE1   . GLN A 1 289 ? 1.413   85.202  27.877  1.00 23.28 ? 582  GLN A OE1   1 
ATOM   2267 N NE2   . GLN A 1 289 ? 0.060   86.960  28.149  1.00 23.97 ? 582  GLN A NE2   1 
ATOM   2268 N N     . SER A 1 290 ? 5.256   84.852  32.745  1.00 24.33 ? 583  SER A N     1 
ATOM   2269 C CA    . SER A 1 290 ? 5.810   83.827  33.617  1.00 26.47 ? 583  SER A CA    1 
ATOM   2270 C C     . SER A 1 290 ? 6.616   84.442  34.760  1.00 26.33 ? 583  SER A C     1 
ATOM   2271 O O     . SER A 1 290 ? 7.466   83.766  35.324  1.00 29.52 ? 583  SER A O     1 
ATOM   2272 C CB    . SER A 1 290 ? 6.649   82.830  32.836  1.00 25.03 ? 583  SER A CB    1 
ATOM   2273 O OG    . SER A 1 290 ? 7.874   83.424  32.409  1.00 27.76 ? 583  SER A OG    1 
ATOM   2274 N N     . ILE A 1 291 ? 6.350   85.695  35.128  1.00 27.05 ? 584  ILE A N     1 
ATOM   2275 C CA    . ILE A 1 291 ? 7.096   86.301  36.224  1.00 28.47 ? 584  ILE A CA    1 
ATOM   2276 C C     . ILE A 1 291 ? 6.704   85.600  37.527  1.00 28.70 ? 584  ILE A C     1 
ATOM   2277 O O     . ILE A 1 291 ? 5.518   85.466  37.831  1.00 27.47 ? 584  ILE A O     1 
ATOM   2278 C CB    . ILE A 1 291 ? 6.874   87.822  36.317  1.00 29.10 ? 584  ILE A CB    1 
ATOM   2279 C CG1   . ILE A 1 291 ? 7.314   88.551  35.040  1.00 29.23 ? 584  ILE A CG1   1 
ATOM   2280 C CG2   . ILE A 1 291 ? 7.560   88.390  37.553  1.00 30.28 ? 584  ILE A CG2   1 
ATOM   2281 C CD1   . ILE A 1 291 ? 8.757   88.305  34.644  1.00 30.03 ? 584  ILE A CD1   1 
ATOM   2282 N N     . PRO A 1 292 ? 7.692   85.080  38.293  1.00 28.52 ? 585  PRO A N     1 
ATOM   2283 C CA    . PRO A 1 292 ? 7.426   84.345  39.531  1.00 29.84 ? 585  PRO A CA    1 
ATOM   2284 C C     . PRO A 1 292 ? 6.551   85.127  40.502  1.00 28.76 ? 585  PRO A C     1 
ATOM   2285 O O     . PRO A 1 292 ? 6.581   86.359  40.521  1.00 30.99 ? 585  PRO A O     1 
ATOM   2286 C CB    . PRO A 1 292 ? 8.826   84.105  40.107  1.00 28.68 ? 585  PRO A CB    1 
ATOM   2287 C CG    . PRO A 1 292 ? 9.711   84.042  38.878  1.00 28.77 ? 585  PRO A CG    1 
ATOM   2288 C CD    . PRO A 1 292 ? 9.127   85.081  37.947  1.00 29.35 ? 585  PRO A CD    1 
ATOM   2289 N N     . VAL A 1 293 ? 5.747   84.374  41.257  1.00 29.96 ? 586  VAL A N     1 
ATOM   2290 C CA    . VAL A 1 293 ? 4.784   84.937  42.190  1.00 30.92 ? 586  VAL A CA    1 
ATOM   2291 C C     . VAL A 1 293 ? 4.462   83.960  43.324  1.00 32.39 ? 586  VAL A C     1 
ATOM   2292 O O     . VAL A 1 293 ? 4.000   84.393  44.371  1.00 33.19 ? 586  VAL A O     1 
ATOM   2293 C CB    . VAL A 1 293 ? 3.482   85.348  41.477  1.00 30.95 ? 586  VAL A CB    1 
ATOM   2294 C CG1   . VAL A 1 293 ? 2.714   84.147  40.956  1.00 31.14 ? 586  VAL A CG1   1 
ATOM   2295 C CG2   . VAL A 1 293 ? 2.581   86.189  42.373  1.00 31.48 ? 586  VAL A CG2   1 
ATOM   2296 N N     . ARG A 1 294 ? 4.660   82.655  43.127  1.00 30.26 ? 587  ARG A N     1 
ATOM   2297 C CA    . ARG A 1 294 ? 4.060   81.679  44.027  1.00 35.64 ? 587  ARG A CA    1 
ATOM   2298 C C     . ARG A 1 294 ? 4.890   81.442  45.296  1.00 36.26 ? 587  ARG A C     1 
ATOM   2299 O O     . ARG A 1 294 ? 4.317   81.184  46.351  1.00 39.18 ? 587  ARG A O     1 
ATOM   2300 C CB    . ARG A 1 294 ? 3.803   80.370  43.278  1.00 33.67 ? 587  ARG A CB    1 
ATOM   2301 C CG    . ARG A 1 294 ? 2.660   80.479  42.280  1.00 33.67 ? 587  ARG A CG    1 
ATOM   2302 C CD    . ARG A 1 294 ? 2.470   79.193  41.501  1.00 32.37 ? 587  ARG A CD    1 
ATOM   2303 N NE    . ARG A 1 294 ? 1.648   79.438  40.326  1.00 32.90 ? 587  ARG A NE    1 
ATOM   2304 C CZ    . ARG A 1 294 ? 1.480   78.569  39.339  1.00 32.59 ? 587  ARG A CZ    1 
ATOM   2305 N NH1   . ARG A 1 294 ? 1.843   77.309  39.500  1.00 31.46 ? 587  ARG A NH1   1 
ATOM   2306 N NH2   . ARG A 1 294 ? 0.958   78.965  38.193  1.00 31.72 ? 587  ARG A NH2   1 
ATOM   2307 N N     . THR A 1 295 ? 6.222   81.478  45.192  1.00 35.49 ? 588  THR A N     1 
ATOM   2308 C CA    . THR A 1 295 ? 7.096   81.253  46.333  1.00 36.07 ? 588  THR A CA    1 
ATOM   2309 C C     . THR A 1 295 ? 7.429   82.578  47.021  1.00 38.31 ? 588  THR A C     1 
ATOM   2310 O O     . THR A 1 295 ? 7.189   83.648  46.460  1.00 33.52 ? 588  THR A O     1 
ATOM   2311 C CB    . THR A 1 295 ? 8.381   80.531  45.907  1.00 35.34 ? 588  THR A CB    1 
ATOM   2312 O OG1   . THR A 1 295 ? 9.160   81.363  45.040  1.00 34.95 ? 588  THR A OG1   1 
ATOM   2313 C CG2   . THR A 1 295 ? 8.088   79.218  45.219  1.00 33.16 ? 588  THR A CG2   1 
ATOM   2314 N N     . PRO A 1 296 ? 7.993   82.551  48.255  1.00 39.64 ? 589  PRO A N     1 
ATOM   2315 C CA    . PRO A 1 296 ? 8.512   83.764  48.894  1.00 40.35 ? 589  PRO A CA    1 
ATOM   2316 C C     . PRO A 1 296 ? 9.451   84.588  48.016  1.00 37.56 ? 589  PRO A C     1 
ATOM   2317 O O     . PRO A 1 296 ? 9.259   85.793  47.910  1.00 40.55 ? 589  PRO A O     1 
ATOM   2318 C CB    . PRO A 1 296 ? 9.204   83.220  50.157  1.00 41.37 ? 589  PRO A CB    1 
ATOM   2319 C CG    . PRO A 1 296 ? 8.362   82.010  50.505  1.00 41.30 ? 589  PRO A CG    1 
ATOM   2320 C CD    . PRO A 1 296 ? 8.058   81.383  49.154  1.00 39.55 ? 589  PRO A CD    1 
ATOM   2321 N N     . LEU A 1 297 ? 10.439  83.957  47.365  1.00 38.04 ? 590  LEU A N     1 
ATOM   2322 C CA    . LEU A 1 297 ? 11.330  84.704  46.478  1.00 36.44 ? 590  LEU A CA    1 
ATOM   2323 C C     . LEU A 1 297 ? 10.573  85.216  45.243  1.00 35.98 ? 590  LEU A C     1 
ATOM   2324 O O     . LEU A 1 297 ? 10.816  86.328  44.771  1.00 36.13 ? 590  LEU A O     1 
ATOM   2325 C CB    . LEU A 1 297 ? 12.522  83.833  46.073  1.00 35.95 ? 590  LEU A CB    1 
ATOM   2326 C CG    . LEU A 1 297 ? 13.540  84.499  45.139  1.00 36.94 ? 590  LEU A CG    1 
ATOM   2327 C CD1   . LEU A 1 297 ? 14.086  85.789  45.740  1.00 38.18 ? 590  LEU A CD1   1 
ATOM   2328 C CD2   . LEU A 1 297 ? 14.694  83.562  44.803  1.00 38.84 ? 590  LEU A CD2   1 
ATOM   2329 N N     . GLY A 1 298 ? 9.654   84.408  44.703  1.00 33.63 ? 591  GLY A N     1 
ATOM   2330 C CA    . GLY A 1 298 ? 8.848   84.852  43.574  1.00 32.07 ? 591  GLY A CA    1 
ATOM   2331 C C     . GLY A 1 298 ? 8.107   86.149  43.874  1.00 31.25 ? 591  GLY A C     1 
ATOM   2332 O O     . GLY A 1 298 ? 8.123   87.086  43.075  1.00 32.81 ? 591  GLY A O     1 
ATOM   2333 N N     . GLN A 1 299 ? 7.460   86.201  45.041  1.00 31.68 ? 592  GLN A N     1 
ATOM   2334 C CA    . GLN A 1 299 ? 6.755   87.397  45.474  1.00 37.82 ? 592  GLN A CA    1 
ATOM   2335 C C     . GLN A 1 299 ? 7.696   88.599  45.481  1.00 36.32 ? 592  GLN A C     1 
ATOM   2336 O O     . GLN A 1 299 ? 7.291   89.718  45.180  1.00 39.03 ? 592  GLN A O     1 
ATOM   2337 C CB    . GLN A 1 299 ? 6.202   87.216  46.884  1.00 40.92 ? 592  GLN A CB    1 
ATOM   2338 C CG    . GLN A 1 299 ? 4.960   86.351  46.955  1.00 46.03 ? 592  GLN A CG    1 
ATOM   2339 C CD    . GLN A 1 299 ? 4.438   86.370  48.365  1.00 49.34 ? 592  GLN A CD    1 
ATOM   2340 O OE1   . GLN A 1 299 ? 5.075   85.857  49.279  1.00 55.69 ? 592  GLN A OE1   1 
ATOM   2341 N NE2   . GLN A 1 299 ? 3.293   87.007  48.555  1.00 58.35 ? 592  GLN A NE2   1 
ATOM   2342 N N     . ARG A 1 300 ? 8.954   88.364  45.842  1.00 36.75 ? 593  ARG A N     1 
ATOM   2343 C CA    . ARG A 1 300 ? 9.904   89.456  45.961  1.00 39.19 ? 593  ARG A CA    1 
ATOM   2344 C C     . ARG A 1 300 ? 10.286  89.969  44.575  1.00 38.28 ? 593  ARG A C     1 
ATOM   2345 O O     . ARG A 1 300 ? 10.525  91.161  44.415  1.00 35.07 ? 593  ARG A O     1 
ATOM   2346 C CB    . ARG A 1 300 ? 11.081  89.013  46.826  1.00 41.24 ? 593  ARG A CB    1 
ATOM   2347 C CG    . ARG A 1 300 ? 10.674  88.751  48.269  1.00 43.83 ? 593  ARG A CG    1 
ATOM   2348 C CD    . ARG A 1 300 ? 11.853  88.394  49.144  1.00 46.39 ? 593  ARG A CD    1 
ATOM   2349 N NE    . ARG A 1 300 ? 12.824  89.477  49.252  1.00 47.05 ? 593  ARG A NE    1 
ATOM   2350 C CZ    . ARG A 1 300 ? 14.107  89.298  49.538  1.00 48.06 ? 593  ARG A CZ    1 
ATOM   2351 N NH1   . ARG A 1 300 ? 14.591  88.076  49.655  1.00 47.35 ? 593  ARG A NH1   1 
ATOM   2352 N NH2   . ARG A 1 300 ? 14.914  90.338  49.673  1.00 52.88 ? 593  ARG A NH2   1 
ATOM   2353 N N     . ILE A 1 301 ? 10.260  89.090  43.566  1.00 35.77 ? 594  ILE A N     1 
ATOM   2354 C CA    . ILE A 1 301 ? 10.519  89.514  42.198  1.00 34.89 ? 594  ILE A CA    1 
ATOM   2355 C C     . ILE A 1 301 ? 9.382   90.416  41.709  1.00 33.85 ? 594  ILE A C     1 
ATOM   2356 O O     . ILE A 1 301 ? 9.636   91.440  41.081  1.00 32.70 ? 594  ILE A O     1 
ATOM   2357 C CB    . ILE A 1 301 ? 10.756  88.298  41.279  1.00 34.04 ? 594  ILE A CB    1 
ATOM   2358 C CG1   . ILE A 1 301 ? 11.998  87.519  41.714  1.00 35.16 ? 594  ILE A CG1   1 
ATOM   2359 C CG2   . ILE A 1 301 ? 10.853  88.732  39.820  1.00 33.43 ? 594  ILE A CG2   1 
ATOM   2360 C CD1   . ILE A 1 301 ? 12.115  86.139  41.110  1.00 36.28 ? 594  ILE A CD1   1 
ATOM   2361 N N     . ARG A 1 302 ? 8.130   90.045  42.007  1.00 33.99 ? 595  ARG A N     1 
ATOM   2362 C CA    . ARG A 1 302 ? 6.974   90.827  41.599  1.00 34.64 ? 595  ARG A CA    1 
ATOM   2363 C C     . ARG A 1 302 ? 7.062   92.266  42.102  1.00 37.48 ? 595  ARG A C     1 
ATOM   2364 O O     . ARG A 1 302 ? 6.583   93.185  41.436  1.00 39.37 ? 595  ARG A O     1 
ATOM   2365 C CB    . ARG A 1 302 ? 5.674   90.204  42.115  1.00 35.17 ? 595  ARG A CB    1 
ATOM   2366 C CG    . ARG A 1 302 ? 5.233   88.959  41.368  1.00 35.11 ? 595  ARG A CG    1 
ATOM   2367 C CD    . ARG A 1 302 ? 4.714   89.266  39.976  1.00 35.28 ? 595  ARG A CD    1 
ATOM   2368 N NE    . ARG A 1 302 ? 4.393   88.050  39.245  1.00 32.80 ? 595  ARG A NE    1 
ATOM   2369 C CZ    . ARG A 1 302 ? 3.170   87.709  38.852  1.00 33.20 ? 595  ARG A CZ    1 
ATOM   2370 N NH1   . ARG A 1 302 ? 2.133   88.468  39.178  1.00 33.41 ? 595  ARG A NH1   1 
ATOM   2371 N NH2   . ARG A 1 302 ? 2.991   86.603  38.149  1.00 30.24 ? 595  ARG A NH2   1 
ATOM   2372 N N     . ARG A 1 303 ? 7.660   92.460  43.283  1.00 41.39 ? 596  ARG A N     1 
ATOM   2373 C CA    . ARG A 1 303 ? 7.825   93.792  43.847  1.00 43.10 ? 596  ARG A CA    1 
ATOM   2374 C C     . ARG A 1 303 ? 8.698   94.684  42.953  1.00 40.41 ? 596  ARG A C     1 
ATOM   2375 O O     . ARG A 1 303 ? 8.580   95.906  43.022  1.00 40.44 ? 596  ARG A O     1 
ATOM   2376 C CB    . ARG A 1 303 ? 8.406   93.714  45.264  1.00 47.45 ? 596  ARG A CB    1 
ATOM   2377 C CG    . ARG A 1 303 ? 8.108   94.942  46.119  1.00 54.31 ? 596  ARG A CG    1 
ATOM   2378 C CD    . ARG A 1 303 ? 8.724   94.910  47.512  1.00 60.91 ? 596  ARG A CD    1 
ATOM   2379 N NE    . ARG A 1 303 ? 8.599   93.628  48.207  1.00 62.04 ? 596  ARG A NE    1 
ATOM   2380 C CZ    . ARG A 1 303 ? 7.474   93.127  48.720  1.00 66.24 ? 596  ARG A CZ    1 
ATOM   2381 N NH1   . ARG A 1 303 ? 7.501   91.960  49.340  1.00 62.88 ? 596  ARG A NH1   1 
ATOM   2382 N NH2   . ARG A 1 303 ? 6.329   93.786  48.630  1.00 68.36 ? 596  ARG A NH2   1 
ATOM   2383 N N     . ALA A 1 304 ? 9.551   94.097  42.097  1.00 37.88 ? 597  ALA A N     1 
ATOM   2384 C CA    . ALA A 1 304 ? 10.445  94.881  41.249  1.00 36.39 ? 597  ALA A CA    1 
ATOM   2385 C C     . ALA A 1 304 ? 9.701   95.631  40.140  1.00 37.12 ? 597  ALA A C     1 
ATOM   2386 O O     . ALA A 1 304 ? 10.264  96.557  39.551  1.00 37.34 ? 597  ALA A O     1 
ATOM   2387 C CB    . ALA A 1 304 ? 11.513  93.999  40.669  1.00 39.32 ? 597  ALA A CB    1 
ATOM   2388 N N     . PHE A 1 305 ? 8.450   95.239  39.852  1.00 34.05 ? 598  PHE A N     1 
ATOM   2389 C CA    . PHE A 1 305 ? 7.664   95.865  38.803  1.00 33.92 ? 598  PHE A CA    1 
ATOM   2390 C C     . PHE A 1 305 ? 6.868   97.015  39.404  1.00 34.88 ? 598  PHE A C     1 
ATOM   2391 O O     . PHE A 1 305 ? 5.941   96.784  40.182  1.00 35.45 ? 598  PHE A O     1 
ATOM   2392 C CB    . PHE A 1 305 ? 6.747   94.844  38.118  1.00 32.70 ? 598  PHE A CB    1 
ATOM   2393 C CG    . PHE A 1 305 ? 7.481   93.835  37.276  1.00 30.24 ? 598  PHE A CG    1 
ATOM   2394 C CD1   . PHE A 1 305 ? 8.195   92.808  37.874  1.00 30.38 ? 598  PHE A CD1   1 
ATOM   2395 C CD2   . PHE A 1 305 ? 7.505   93.943  35.891  1.00 28.97 ? 598  PHE A CD2   1 
ATOM   2396 C CE1   . PHE A 1 305 ? 8.928   91.916  37.111  1.00 29.19 ? 598  PHE A CE1   1 
ATOM   2397 C CE2   . PHE A 1 305 ? 8.222   93.033  35.132  1.00 29.24 ? 598  PHE A CE2   1 
ATOM   2398 C CZ    . PHE A 1 305 ? 8.937   92.029  35.741  1.00 27.10 ? 598  PHE A CZ    1 
ATOM   2399 N N     . ILE A 1 306 ? 7.215   98.246  39.006  1.00 33.85 ? 599  ILE A N     1 
ATOM   2400 C CA    . ILE A 1 306 ? 6.773   99.431  39.727  1.00 33.37 ? 599  ILE A CA    1 
ATOM   2401 C C     . ILE A 1 306 ? 6.066   100.397 38.776  1.00 35.67 ? 599  ILE A C     1 
ATOM   2402 O O     . ILE A 1 306 ? 6.201   100.298 37.560  1.00 37.45 ? 599  ILE A O     1 
ATOM   2403 C CB    . ILE A 1 306 ? 7.976   100.080 40.446  1.00 36.14 ? 599  ILE A CB    1 
ATOM   2404 C CG1   . ILE A 1 306 ? 9.113   100.439 39.486  1.00 37.86 ? 599  ILE A CG1   1 
ATOM   2405 C CG2   . ILE A 1 306 ? 8.493   99.196  41.568  1.00 35.85 ? 599  ILE A CG2   1 
ATOM   2406 C CD1   . ILE A 1 306 ? 10.100  101.427 40.065  1.00 38.64 ? 599  ILE A CD1   1 
ATOM   2407 N N     . ALA A 1 307 ? 5.304   101.339 39.343  1.00 36.08 ? 600  ALA A N     1 
ATOM   2408 C CA    . ALA A 1 307 ? 4.663   102.392 38.569  1.00 36.96 ? 600  ALA A CA    1 
ATOM   2409 C C     . ALA A 1 307 ? 5.662   103.520 38.282  1.00 37.42 ? 600  ALA A C     1 
ATOM   2410 O O     . ALA A 1 307 ? 6.694   103.632 38.941  1.00 33.83 ? 600  ALA A O     1 
ATOM   2411 C CB    . ALA A 1 307 ? 3.468   102.916 39.322  1.00 35.56 ? 600  ALA A CB    1 
ATOM   2412 N N     . GLU A 1 308 ? 5.357   104.341 37.274  1.00 39.25 ? 601  GLU A N     1 
ATOM   2413 C CA    . GLU A 1 308 ? 6.062   105.599 37.076  1.00 42.95 ? 601  GLU A CA    1 
ATOM   2414 C C     . GLU A 1 308 ? 5.773   106.507 38.278  1.00 43.19 ? 601  GLU A C     1 
ATOM   2415 O O     . GLU A 1 308 ? 4.710   106.404 38.892  1.00 39.23 ? 601  GLU A O     1 
ATOM   2416 C CB    . GLU A 1 308 ? 5.612   106.256 35.770  1.00 45.67 ? 601  GLU A CB    1 
ATOM   2417 C CG    . GLU A 1 308 ? 6.480   107.432 35.332  1.00 48.36 ? 601  GLU A CG    1 
ATOM   2418 C CD    . GLU A 1 308 ? 5.849   108.317 34.271  1.00 52.99 ? 601  GLU A CD    1 
ATOM   2419 O OE1   . GLU A 1 308 ? 5.247   107.776 33.312  1.00 55.03 ? 601  GLU A OE1   1 
ATOM   2420 O OE2   . GLU A 1 308 ? 5.964   109.552 34.397  1.00 60.36 ? 601  GLU A OE2   1 
ATOM   2421 N N     . GLU A 1 309 ? 6.729   107.393 38.594  1.00 44.42 ? 602  GLU A N     1 
ATOM   2422 C CA    . GLU A 1 309 ? 6.577   108.385 39.647  1.00 44.88 ? 602  GLU A CA    1 
ATOM   2423 C C     . GLU A 1 309 ? 5.249   109.118 39.471  1.00 42.62 ? 602  GLU A C     1 
ATOM   2424 O O     . GLU A 1 309 ? 4.957   109.640 38.399  1.00 41.72 ? 602  GLU A O     1 
ATOM   2425 C CB    . GLU A 1 309 ? 7.712   109.410 39.608  1.00 51.14 ? 602  GLU A CB    1 
ATOM   2426 C CG    . GLU A 1 309 ? 9.097   108.834 39.849  1.00 58.56 ? 602  GLU A CG    1 
ATOM   2427 C CD    . GLU A 1 309 ? 9.457   108.555 41.297  1.00 67.31 ? 602  GLU A CD    1 
ATOM   2428 O OE1   . GLU A 1 309 ? 9.369   109.495 42.125  1.00 73.68 ? 602  GLU A OE1   1 
ATOM   2429 O OE2   . GLU A 1 309 ? 9.848   107.403 41.590  1.00 71.56 ? 602  GLU A OE2   1 
ATOM   2430 N N     . GLY A 1 310 ? 4.434   109.137 40.527  1.00 40.06 ? 603  GLY A N     1 
ATOM   2431 C CA    . GLY A 1 310 ? 3.161   109.840 40.494  1.00 40.66 ? 603  GLY A CA    1 
ATOM   2432 C C     . GLY A 1 310 ? 2.028   108.985 39.932  1.00 39.08 ? 603  GLY A C     1 
ATOM   2433 O O     . GLY A 1 310 ? 0.893   109.458 39.856  1.00 42.33 ? 603  GLY A O     1 
ATOM   2434 N N     . TRP A 1 311 ? 2.346   107.736 39.538  1.00 39.96 ? 604  TRP A N     1 
ATOM   2435 C CA    . TRP A 1 311 ? 1.365   106.810 38.981  1.00 39.41 ? 604  TRP A CA    1 
ATOM   2436 C C     . TRP A 1 311 ? 1.188   105.618 39.927  1.00 37.65 ? 604  TRP A C     1 
ATOM   2437 O O     . TRP A 1 311 ? 2.052   105.366 40.760  1.00 36.37 ? 604  TRP A O     1 
ATOM   2438 C CB    . TRP A 1 311 ? 1.802   106.328 37.581  1.00 40.61 ? 604  TRP A CB    1 
ATOM   2439 C CG    . TRP A 1 311 ? 1.846   107.387 36.517  1.00 41.74 ? 604  TRP A CG    1 
ATOM   2440 C CD1   . TRP A 1 311 ? 2.597   108.530 36.520  1.00 42.27 ? 604  TRP A CD1   1 
ATOM   2441 C CD2   . TRP A 1 311 ? 1.113   107.397 35.278  1.00 40.81 ? 604  TRP A CD2   1 
ATOM   2442 N NE1   . TRP A 1 311 ? 2.381   109.247 35.374  1.00 41.99 ? 604  TRP A NE1   1 
ATOM   2443 C CE2   . TRP A 1 311 ? 1.473   108.581 34.594  1.00 43.49 ? 604  TRP A CE2   1 
ATOM   2444 C CE3   . TRP A 1 311 ? 0.196   106.527 34.676  1.00 41.49 ? 604  TRP A CE3   1 
ATOM   2445 C CZ2   . TRP A 1 311 ? 0.950   108.908 33.343  1.00 41.81 ? 604  TRP A CZ2   1 
ATOM   2446 C CZ3   . TRP A 1 311 ? -0.330  106.854 33.445  1.00 43.43 ? 604  TRP A CZ3   1 
ATOM   2447 C CH2   . TRP A 1 311 ? 0.042   108.033 32.790  1.00 43.88 ? 604  TRP A CH2   1 
ATOM   2448 N N     . LEU A 1 312 ? 0.107   104.849 39.728  1.00 39.50 ? 605  LEU A N     1 
ATOM   2449 C CA    . LEU A 1 312 ? -0.113  103.589 40.434  1.00 37.95 ? 605  LEU A CA    1 
ATOM   2450 C C     . LEU A 1 312 ? -0.486  102.498 39.427  1.00 36.81 ? 605  LEU A C     1 
ATOM   2451 O O     . LEU A 1 312 ? -1.117  102.766 38.407  1.00 36.97 ? 605  LEU A O     1 
ATOM   2452 C CB    . LEU A 1 312 ? -1.223  103.772 41.481  1.00 38.99 ? 605  LEU A CB    1 
ATOM   2453 C CG    . LEU A 1 312 ? -0.892  104.668 42.685  1.00 35.85 ? 605  LEU A CG    1 
ATOM   2454 C CD1   . LEU A 1 312 ? -2.083  104.818 43.623  1.00 37.21 ? 605  LEU A CD1   1 
ATOM   2455 C CD2   . LEU A 1 312 ? 0.288   104.138 43.458  1.00 35.61 ? 605  LEU A CD2   1 
ATOM   2456 N N     . LEU A 1 313 ? -0.082  101.264 39.734  1.00 35.78 ? 606  LEU A N     1 
ATOM   2457 C CA    . LEU A 1 313 ? -0.518  100.095 38.989  1.00 34.73 ? 606  LEU A CA    1 
ATOM   2458 C C     . LEU A 1 313 ? -1.917  99.698  39.436  1.00 36.20 ? 606  LEU A C     1 
ATOM   2459 O O     . LEU A 1 313 ? -2.234  99.768  40.628  1.00 38.79 ? 606  LEU A O     1 
ATOM   2460 C CB    . LEU A 1 313 ? 0.459   98.943  39.245  1.00 32.99 ? 606  LEU A CB    1 
ATOM   2461 C CG    . LEU A 1 313 ? 1.900   99.180  38.810  1.00 34.05 ? 606  LEU A CG    1 
ATOM   2462 C CD1   . LEU A 1 313 ? 2.726   97.900  38.938  1.00 33.95 ? 606  LEU A CD1   1 
ATOM   2463 C CD2   . LEU A 1 313 ? 1.950   99.714  37.388  1.00 33.42 ? 606  LEU A CD2   1 
ATOM   2464 N N     . VAL A 1 314 ? -2.736  99.271  38.470  1.00 33.90 ? 607  VAL A N     1 
ATOM   2465 C CA    . VAL A 1 314 ? -4.024  98.656  38.746  1.00 34.23 ? 607  VAL A CA    1 
ATOM   2466 C C     . VAL A 1 314 ? -3.998  97.232  38.197  1.00 35.01 ? 607  VAL A C     1 
ATOM   2467 O O     . VAL A 1 314 ? -3.711  97.032  37.013  1.00 31.23 ? 607  VAL A O     1 
ATOM   2468 C CB    . VAL A 1 314 ? -5.204  99.444  38.146  1.00 33.52 ? 607  VAL A CB    1 
ATOM   2469 C CG1   . VAL A 1 314 ? -6.545  98.833  38.545  1.00 34.35 ? 607  VAL A CG1   1 
ATOM   2470 C CG2   . VAL A 1 314 ? -5.153  100.914 38.526  1.00 36.30 ? 607  VAL A CG2   1 
ATOM   2471 N N     . ALA A 1 315 ? -4.288  96.261  39.074  1.00 33.26 ? 608  ALA A N     1 
ATOM   2472 C CA    . ALA A 1 315 ? -4.216  94.849  38.728  1.00 31.56 ? 608  ALA A CA    1 
ATOM   2473 C C     . ALA A 1 315 ? -5.609  94.238  38.806  1.00 30.90 ? 608  ALA A C     1 
ATOM   2474 O O     . ALA A 1 315 ? -6.268  94.276  39.849  1.00 30.46 ? 608  ALA A O     1 
ATOM   2475 C CB    . ALA A 1 315 ? -3.252  94.143  39.638  1.00 33.69 ? 608  ALA A CB    1 
ATOM   2476 N N     . LEU A 1 316 ? -6.072  93.697  37.683  1.00 27.35 ? 609  LEU A N     1 
ATOM   2477 C CA    . LEU A 1 316 ? -7.425  93.176  37.607  1.00 29.63 ? 609  LEU A CA    1 
ATOM   2478 C C     . LEU A 1 316 ? -7.359  91.707  37.226  1.00 30.17 ? 609  LEU A C     1 
ATOM   2479 O O     . LEU A 1 316 ? -6.571  91.337  36.362  1.00 28.12 ? 609  LEU A O     1 
ATOM   2480 C CB    . LEU A 1 316 ? -8.241  93.949  36.572  1.00 27.93 ? 609  LEU A CB    1 
ATOM   2481 C CG    . LEU A 1 316 ? -8.454  95.439  36.850  1.00 30.17 ? 609  LEU A CG    1 
ATOM   2482 C CD1   . LEU A 1 316 ? -7.631  96.300  35.903  1.00 32.37 ? 609  LEU A CD1   1 
ATOM   2483 C CD2   . LEU A 1 316 ? -9.924  95.788  36.759  1.00 28.76 ? 609  LEU A CD2   1 
ATOM   2484 N N     . ASP A 1 317 ? -8.268  90.912  37.791  1.00 28.51 ? 610  ASP A N     1 
ATOM   2485 C CA    . ASP A 1 317 ? -8.159  89.466  37.691  1.00 31.68 ? 610  ASP A CA    1 
ATOM   2486 C C     . ASP A 1 317 ? -9.564  88.873  37.592  1.00 26.46 ? 610  ASP A C     1 
ATOM   2487 O O     . ASP A 1 317 ? -10.394 89.079  38.483  1.00 29.36 ? 610  ASP A O     1 
ATOM   2488 C CB    . ASP A 1 317 ? -7.306  88.991  38.878  1.00 37.59 ? 610  ASP A CB    1 
ATOM   2489 C CG    . ASP A 1 317 ? -7.104  87.497  39.004  1.00 43.96 ? 610  ASP A CG    1 
ATOM   2490 O OD1   . ASP A 1 317 ? -6.951  86.828  37.949  1.00 48.79 ? 610  ASP A OD1   1 
ATOM   2491 O OD2   . ASP A 1 317 ? -7.037  87.020  40.158  1.00 50.83 ? 610  ASP A OD2   1 
ATOM   2492 N N     . TYR A 1 318 ? -9.846  88.168  36.494  1.00 24.41 ? 611  TYR A N     1 
ATOM   2493 C CA    . TYR A 1 318 ? -11.052 87.352  36.406  1.00 25.43 ? 611  TYR A CA    1 
ATOM   2494 C C     . TYR A 1 318 ? -10.901 86.163  37.352  1.00 27.77 ? 611  TYR A C     1 
ATOM   2495 O O     . TYR A 1 318 ? -10.008 85.338  37.198  1.00 29.96 ? 611  TYR A O     1 
ATOM   2496 C CB    . TYR A 1 318 ? -11.334 86.843  34.985  1.00 26.94 ? 611  TYR A CB    1 
ATOM   2497 C CG    . TYR A 1 318 ? -11.890 87.840  33.985  1.00 27.68 ? 611  TYR A CG    1 
ATOM   2498 C CD1   . TYR A 1 318 ? -13.140 88.427  34.155  1.00 27.71 ? 611  TYR A CD1   1 
ATOM   2499 C CD2   . TYR A 1 318 ? -11.163 88.199  32.860  1.00 26.55 ? 611  TYR A CD2   1 
ATOM   2500 C CE1   . TYR A 1 318 ? -13.651 89.333  33.234  1.00 27.91 ? 611  TYR A CE1   1 
ATOM   2501 C CE2   . TYR A 1 318 ? -11.656 89.100  31.933  1.00 27.85 ? 611  TYR A CE2   1 
ATOM   2502 C CZ    . TYR A 1 318 ? -12.913 89.657  32.111  1.00 27.19 ? 611  TYR A CZ    1 
ATOM   2503 O OH    . TYR A 1 318 ? -13.378 90.548  31.186  1.00 26.06 ? 611  TYR A OH    1 
ATOM   2504 N N     . SER A 1 319 ? -11.825 86.053  38.300  1.00 26.39 ? 612  SER A N     1 
ATOM   2505 C CA    . SER A 1 319 ? -11.800 85.004  39.295  1.00 29.83 ? 612  SER A CA    1 
ATOM   2506 C C     . SER A 1 319 ? -12.478 83.744  38.749  1.00 28.77 ? 612  SER A C     1 
ATOM   2507 O O     . SER A 1 319 ? -13.588 83.805  38.234  1.00 26.41 ? 612  SER A O     1 
ATOM   2508 C CB    . SER A 1 319 ? -12.462 85.497  40.557  1.00 31.81 ? 612  SER A CB    1 
ATOM   2509 O OG    . SER A 1 319 ? -12.173 84.614  41.615  1.00 41.08 ? 612  SER A OG    1 
ATOM   2510 N N     . GLN A 1 320 ? -11.759 82.614  38.823  1.00 28.73 ? 613  GLN A N     1 
ATOM   2511 C CA    . GLN A 1 320 ? -12.226 81.308  38.376  1.00 30.78 ? 613  GLN A CA    1 
ATOM   2512 C C     . GLN A 1 320 ? -12.858 81.329  36.990  1.00 26.59 ? 613  GLN A C     1 
ATOM   2513 O O     . GLN A 1 320 ? -13.887 80.693  36.762  1.00 24.84 ? 613  GLN A O     1 
ATOM   2514 C CB    . GLN A 1 320 ? -13.148 80.728  39.443  1.00 32.74 ? 613  GLN A CB    1 
ATOM   2515 C CG    . GLN A 1 320 ? -12.312 80.133  40.558  1.00 37.79 ? 613  GLN A CG    1 
ATOM   2516 C CD    . GLN A 1 320 ? -13.006 80.230  41.880  1.00 41.33 ? 613  GLN A CD    1 
ATOM   2517 O OE1   . GLN A 1 320 ? -14.062 80.848  41.979  1.00 44.20 ? 613  GLN A OE1   1 
ATOM   2518 N NE2   . GLN A 1 320 ? -12.416 79.604  42.886  1.00 39.72 ? 613  GLN A NE2   1 
ATOM   2519 N N     . GLU A 1 321 ? -12.162 81.959  36.033  1.00 27.41 ? 614  GLU A N     1 
ATOM   2520 C CA    . GLU A 1 321 ? -12.738 82.222  34.730  1.00 28.38 ? 614  GLU A CA    1 
ATOM   2521 C C     . GLU A 1 321 ? -13.015 80.910  33.997  1.00 27.82 ? 614  GLU A C     1 
ATOM   2522 O O     . GLU A 1 321 ? -14.013 80.836  33.297  1.00 26.37 ? 614  GLU A O     1 
ATOM   2523 C CB    . GLU A 1 321 ? -11.887 83.201  33.911  1.00 34.48 ? 614  GLU A CB    1 
ATOM   2524 C CG    . GLU A 1 321 ? -10.622 82.619  33.298  1.00 44.07 ? 614  GLU A CG    1 
ATOM   2525 C CD    . GLU A 1 321 ? -9.433  82.310  34.201  1.00 46.70 ? 614  GLU A CD    1 
ATOM   2526 O OE1   . GLU A 1 321 ? -9.456  82.641  35.422  1.00 48.13 ? 614  GLU A OE1   1 
ATOM   2527 O OE2   . GLU A 1 321 ? -8.472  81.735  33.667  1.00 54.22 ? 614  GLU A OE2   1 
ATOM   2528 N N     . GLY A 1 322 ? -12.152 79.886  34.152  1.00 26.63 ? 615  GLY A N     1 
ATOM   2529 C CA    . GLY A 1 322 ? -12.337 78.615  33.464  1.00 24.19 ? 615  GLY A CA    1 
ATOM   2530 C C     . GLY A 1 322 ? -13.606 77.882  33.905  1.00 24.37 ? 615  GLY A C     1 
ATOM   2531 O O     . GLY A 1 322 ? -14.337 77.305  33.085  1.00 24.47 ? 615  GLY A O     1 
ATOM   2532 N N     . LEU A 1 323 ? -13.841 77.870  35.217  1.00 24.25 ? 616  LEU A N     1 
ATOM   2533 C CA    . LEU A 1 323 ? -14.998 77.184  35.765  1.00 25.58 ? 616  LEU A CA    1 
ATOM   2534 C C     . LEU A 1 323 ? -16.280 77.954  35.423  1.00 25.86 ? 616  LEU A C     1 
ATOM   2535 O O     . LEU A 1 323 ? -17.297 77.325  35.139  1.00 23.85 ? 616  LEU A O     1 
ATOM   2536 C CB    . LEU A 1 323 ? -14.809 77.008  37.272  1.00 26.33 ? 616  LEU A CB    1 
ATOM   2537 C CG    . LEU A 1 323 ? -13.710 76.024  37.688  1.00 26.97 ? 616  LEU A CG    1 
ATOM   2538 C CD1   . LEU A 1 323 ? -13.672 75.898  39.201  1.00 27.99 ? 616  LEU A CD1   1 
ATOM   2539 C CD2   . LEU A 1 323 ? -13.906 74.653  37.048  1.00 27.57 ? 616  LEU A CD2   1 
ATOM   2540 N N     . ARG A 1 324 ? -16.224 79.297  35.405  1.00 25.78 ? 617  ARG A N     1 
ATOM   2541 C CA    . ARG A 1 324 ? -17.380 80.095  34.996  1.00 27.52 ? 617  ARG A CA    1 
ATOM   2542 C C     . ARG A 1 324 ? -17.700 79.841  33.521  1.00 29.66 ? 617  ARG A C     1 
ATOM   2543 O O     . ARG A 1 324 ? -18.874 79.687  33.159  1.00 28.26 ? 617  ARG A O     1 
ATOM   2544 C CB    . ARG A 1 324 ? -17.161 81.583  35.277  1.00 25.83 ? 617  ARG A CB    1 
ATOM   2545 C CG    . ARG A 1 324 ? -17.135 81.937  36.759  1.00 26.57 ? 617  ARG A CG    1 
ATOM   2546 C CD    . ARG A 1 324 ? -16.676 83.369  36.971  1.00 26.56 ? 617  ARG A CD    1 
ATOM   2547 N NE    . ARG A 1 324 ? -16.423 83.689  38.364  1.00 26.52 ? 617  ARG A NE    1 
ATOM   2548 C CZ    . ARG A 1 324 ? -17.364 84.002  39.259  1.00 29.32 ? 617  ARG A CZ    1 
ATOM   2549 N NH1   . ARG A 1 324 ? -18.618 84.188  38.889  1.00 29.42 ? 617  ARG A NH1   1 
ATOM   2550 N NH2   . ARG A 1 324 ? -17.043 84.124  40.531  1.00 31.07 ? 617  ARG A NH2   1 
ATOM   2551 N N     . VAL A 1 325 ? -16.653 79.729  32.677  1.00 26.11 ? 618  VAL A N     1 
ATOM   2552 C CA    . VAL A 1 325 ? -16.863 79.421  31.274  1.00 24.25 ? 618  VAL A CA    1 
ATOM   2553 C C     . VAL A 1 325 ? -17.501 78.037  31.138  1.00 24.49 ? 618  VAL A C     1 
ATOM   2554 O O     . VAL A 1 325 ? -18.464 77.886  30.376  1.00 26.48 ? 618  VAL A O     1 
ATOM   2555 C CB    . VAL A 1 325 ? -15.568 79.600  30.450  1.00 25.62 ? 618  VAL A CB    1 
ATOM   2556 C CG1   . VAL A 1 325 ? -15.599 78.852  29.137  1.00 24.02 ? 618  VAL A CG1   1 
ATOM   2557 C CG2   . VAL A 1 325 ? -15.264 81.071  30.201  1.00 26.83 ? 618  VAL A CG2   1 
ATOM   2558 N N     . LEU A 1 326 ? -17.025 77.059  31.921  1.00 23.04 ? 619  LEU A N     1 
ATOM   2559 C CA    . LEU A 1 326 ? -17.575 75.707  31.905  1.00 25.10 ? 619  LEU A CA    1 
ATOM   2560 C C     . LEU A 1 326 ? -19.062 75.709  32.276  1.00 24.25 ? 619  LEU A C     1 
ATOM   2561 O O     . LEU A 1 326 ? -19.851 74.937  31.747  1.00 24.07 ? 619  LEU A O     1 
ATOM   2562 C CB    . LEU A 1 326 ? -16.791 74.822  32.885  1.00 25.02 ? 619  LEU A CB    1 
ATOM   2563 C CG    . LEU A 1 326 ? -17.345 73.405  33.056  1.00 25.20 ? 619  LEU A CG    1 
ATOM   2564 C CD1   . LEU A 1 326 ? -17.113 72.576  31.803  1.00 24.73 ? 619  LEU A CD1   1 
ATOM   2565 C CD2   . LEU A 1 326 ? -16.746 72.717  34.273  1.00 26.62 ? 619  LEU A CD2   1 
ATOM   2566 N N     . ALA A 1 327 ? -19.426 76.540  33.243  1.00 26.19 ? 620  ALA A N     1 
ATOM   2567 C CA    . ALA A 1 327 ? -20.805 76.679  33.671  1.00 26.44 ? 620  ALA A CA    1 
ATOM   2568 C C     . ALA A 1 327 ? -21.668 77.150  32.496  1.00 27.40 ? 620  ALA A C     1 
ATOM   2569 O O     . ALA A 1 327 ? -22.710 76.561  32.186  1.00 27.99 ? 620  ALA A O     1 
ATOM   2570 C CB    . ALA A 1 327 ? -20.853 77.617  34.859  1.00 27.27 ? 620  ALA A CB    1 
ATOM   2571 N N     . HIS A 1 328 ? -21.185 78.173  31.789  1.00 27.73 ? 621  HIS A N     1 
ATOM   2572 C CA    . HIS A 1 328 ? -21.866 78.678  30.609  1.00 27.62 ? 621  HIS A CA    1 
ATOM   2573 C C     . HIS A 1 328 ? -21.908 77.643  29.484  1.00 29.63 ? 621  HIS A C     1 
ATOM   2574 O O     . HIS A 1 328 ? -22.958 77.441  28.883  1.00 29.19 ? 621  HIS A O     1 
ATOM   2575 C CB    . HIS A 1 328 ? -21.212 79.971  30.111  1.00 29.13 ? 621  HIS A CB    1 
ATOM   2576 C CG    . HIS A 1 328 ? -21.977 80.631  29.001  1.00 29.86 ? 621  HIS A CG    1 
ATOM   2577 N ND1   . HIS A 1 328 ? -23.044 81.494  29.199  1.00 27.89 ? 621  HIS A ND1   1 
ATOM   2578 C CD2   . HIS A 1 328 ? -21.808 80.485  27.657  1.00 28.53 ? 621  HIS A CD2   1 
ATOM   2579 C CE1   . HIS A 1 328 ? -23.511 81.881  28.012  1.00 28.34 ? 621  HIS A CE1   1 
ATOM   2580 N NE2   . HIS A 1 328 ? -22.761 81.248  27.032  1.00 29.90 ? 621  HIS A NE2   1 
ATOM   2581 N N     . LEU A 1 329 ? -20.770 77.007  29.154  1.00 28.10 ? 622  LEU A N     1 
ATOM   2582 C CA    . LEU A 1 329 ? -20.733 76.114  28.007  1.00 27.62 ? 622  LEU A CA    1 
ATOM   2583 C C     . LEU A 1 329 ? -21.593 74.879  28.266  1.00 26.78 ? 622  LEU A C     1 
ATOM   2584 O O     . LEU A 1 329 ? -22.101 74.301  27.314  1.00 29.17 ? 622  LEU A O     1 
ATOM   2585 C CB    . LEU A 1 329 ? -19.298 75.670  27.688  1.00 26.71 ? 622  LEU A CB    1 
ATOM   2586 C CG    . LEU A 1 329 ? -18.336 76.741  27.174  1.00 29.00 ? 622  LEU A CG    1 
ATOM   2587 C CD1   . LEU A 1 329 ? -16.978 76.128  26.860  1.00 29.52 ? 622  LEU A CD1   1 
ATOM   2588 C CD2   . LEU A 1 329 ? -18.877 77.447  25.943  1.00 29.68 ? 622  LEU A CD2   1 
ATOM   2589 N N     . SER A 1 330 ? -21.656 74.419  29.521  1.00 29.43 ? 623  SER A N     1 
ATOM   2590 C CA    . SER A 1 330 ? -22.301 73.153  29.855  1.00 30.11 ? 623  SER A CA    1 
ATOM   2591 C C     . SER A 1 330 ? -23.788 73.372  30.123  1.00 31.83 ? 623  SER A C     1 
ATOM   2592 O O     . SER A 1 330 ? -24.609 72.474  29.912  1.00 30.33 ? 623  SER A O     1 
ATOM   2593 C CB    . SER A 1 330 ? -21.640 72.478  31.033  1.00 29.40 ? 623  SER A CB    1 
ATOM   2594 O OG    . SER A 1 330 ? -21.823 73.205  32.239  1.00 25.84 ? 623  SER A OG    1 
ATOM   2595 N N     . GLY A 1 331 ? -24.107 74.566  30.620  1.00 30.17 ? 624  GLY A N     1 
ATOM   2596 C CA    . GLY A 1 331 ? -25.456 74.873  31.050  1.00 33.25 ? 624  GLY A CA    1 
ATOM   2597 C C     . GLY A 1 331 ? -25.812 74.174  32.359  1.00 33.83 ? 624  GLY A C     1 
ATOM   2598 O O     . GLY A 1 331 ? -26.988 74.085  32.690  1.00 35.79 ? 624  GLY A O     1 
ATOM   2599 N N     . ASP A 1 332 ? -24.813 73.675  33.104  1.00 32.83 ? 625  ASP A N     1 
ATOM   2600 C CA    . ASP A 1 332 ? -25.118 72.897  34.292  1.00 33.32 ? 625  ASP A CA    1 
ATOM   2601 C C     . ASP A 1 332 ? -25.730 73.824  35.338  1.00 34.76 ? 625  ASP A C     1 
ATOM   2602 O O     . ASP A 1 332 ? -25.068 74.737  35.838  1.00 30.08 ? 625  ASP A O     1 
ATOM   2603 C CB    . ASP A 1 332 ? -23.928 72.145  34.888  1.00 31.19 ? 625  ASP A CB    1 
ATOM   2604 C CG    . ASP A 1 332 ? -24.411 71.176  35.960  1.00 34.08 ? 625  ASP A CG    1 
ATOM   2605 O OD1   . ASP A 1 332 ? -24.840 70.044  35.605  1.00 36.14 ? 625  ASP A OD1   1 
ATOM   2606 O OD2   . ASP A 1 332 ? -24.452 71.590  37.130  1.00 30.39 ? 625  ASP A OD2   1 
ATOM   2607 N N     . GLU A 1 333 ? -26.998 73.562  35.680  1.00 34.37 ? 626  GLU A N     1 
ATOM   2608 C CA    . GLU A 1 333 ? -27.752 74.521  36.474  1.00 37.96 ? 626  GLU A CA    1 
ATOM   2609 C C     . GLU A 1 333 ? -27.161 74.625  37.878  1.00 34.05 ? 626  GLU A C     1 
ATOM   2610 O O     . GLU A 1 333 ? -27.200 75.709  38.454  1.00 31.99 ? 626  GLU A O     1 
ATOM   2611 C CB    . GLU A 1 333 ? -29.266 74.251  36.482  1.00 41.67 ? 626  GLU A CB    1 
ATOM   2612 C CG    . GLU A 1 333 ? -29.682 72.792  36.410  1.00 49.52 ? 626  GLU A CG    1 
ATOM   2613 C CD    . GLU A 1 333 ? -29.952 72.245  35.015  1.00 49.85 ? 626  GLU A CD    1 
ATOM   2614 O OE1   . GLU A 1 333 ? -31.127 72.221  34.611  1.00 57.88 ? 626  GLU A OE1   1 
ATOM   2615 O OE2   . GLU A 1 333 ? -29.006 71.780  34.371  1.00 47.53 ? 626  GLU A OE2   1 
ATOM   2616 N N     . ASN A 1 334 ? -26.582 73.524  38.396  1.00 32.01 ? 627  ASN A N     1 
ATOM   2617 C CA    . ASN A 1 334 ? -26.016 73.492  39.739  1.00 34.55 ? 627  ASN A CA    1 
ATOM   2618 C C     . ASN A 1 334 ? -24.721 74.312  39.810  1.00 34.07 ? 627  ASN A C     1 
ATOM   2619 O O     . ASN A 1 334 ? -24.493 75.045  40.772  1.00 32.38 ? 627  ASN A O     1 
ATOM   2620 C CB    . ASN A 1 334 ? -25.857 72.046  40.220  1.00 40.88 ? 627  ASN A CB    1 
ATOM   2621 C CG    . ASN A 1 334 ? -27.178 71.296  40.323  1.00 49.33 ? 627  ASN A CG    1 
ATOM   2622 O OD1   . ASN A 1 334 ? -28.252 71.886  40.500  1.00 50.10 ? 627  ASN A OD1   1 
ATOM   2623 N ND2   . ASN A 1 334 ? -27.107 69.976  40.231  1.00 50.68 ? 627  ASN A ND2   1 
ATOM   2624 N N     . LEU A 1 335 ? -23.886 74.215  38.771  1.00 33.14 ? 628  LEU A N     1 
ATOM   2625 C CA    . LEU A 1 335 ? -22.680 75.021  38.649  1.00 31.37 ? 628  LEU A CA    1 
ATOM   2626 C C     . LEU A 1 335 ? -23.038 76.499  38.434  1.00 29.32 ? 628  LEU A C     1 
ATOM   2627 O O     . LEU A 1 335 ? -22.448 77.385  39.046  1.00 30.01 ? 628  LEU A O     1 
ATOM   2628 C CB    . LEU A 1 335 ? -21.887 74.420  37.486  1.00 32.63 ? 628  LEU A CB    1 
ATOM   2629 C CG    . LEU A 1 335 ? -20.457 74.908  37.294  1.00 34.42 ? 628  LEU A CG    1 
ATOM   2630 C CD1   . LEU A 1 335 ? -19.648 74.721  38.567  1.00 35.97 ? 628  LEU A CD1   1 
ATOM   2631 C CD2   . LEU A 1 335 ? -19.812 74.167  36.126  1.00 34.41 ? 628  LEU A CD2   1 
ATOM   2632 N N     . ILE A 1 336 ? -24.066 76.767  37.621  1.00 30.56 ? 629  ILE A N     1 
ATOM   2633 C CA    . ILE A 1 336 ? -24.543 78.128  37.394  1.00 31.03 ? 629  ILE A CA    1 
ATOM   2634 C C     . ILE A 1 336 ? -25.057 78.753  38.696  1.00 32.81 ? 629  ILE A C     1 
ATOM   2635 O O     . ILE A 1 336 ? -24.717 79.901  39.001  1.00 31.70 ? 629  ILE A O     1 
ATOM   2636 C CB    . ILE A 1 336 ? -25.591 78.135  36.266  1.00 33.07 ? 629  ILE A CB    1 
ATOM   2637 C CG1   . ILE A 1 336 ? -24.908 77.835  34.929  1.00 34.24 ? 629  ILE A CG1   1 
ATOM   2638 C CG2   . ILE A 1 336 ? -26.386 79.439  36.211  1.00 35.36 ? 629  ILE A CG2   1 
ATOM   2639 C CD1   . ILE A 1 336 ? -25.814 77.252  33.890  1.00 35.18 ? 629  ILE A CD1   1 
ATOM   2640 N N     . ARG A 1 337 ? -25.825 77.988  39.488  1.00 33.34 ? 630  ARG A N     1 
ATOM   2641 C CA    . ARG A 1 337 ? -26.390 78.474  40.748  1.00 33.39 ? 630  ARG A CA    1 
ATOM   2642 C C     . ARG A 1 337 ? -25.294 78.924  41.711  1.00 30.55 ? 630  ARG A C     1 
ATOM   2643 O O     . ARG A 1 337 ? -25.393 79.990  42.323  1.00 29.61 ? 630  ARG A O     1 
ATOM   2644 C CB    . ARG A 1 337 ? -27.276 77.404  41.406  1.00 35.89 ? 630  ARG A CB    1 
ATOM   2645 C CG    . ARG A 1 337 ? -28.118 77.909  42.574  1.00 38.76 ? 630  ARG A CG    1 
ATOM   2646 C CD    . ARG A 1 337 ? -28.855 76.788  43.301  1.00 41.89 ? 630  ARG A CD    1 
ATOM   2647 N NE    . ARG A 1 337 ? -29.803 76.106  42.420  1.00 45.54 ? 630  ARG A NE    1 
ATOM   2648 C CZ    . ARG A 1 337 ? -29.595 74.934  41.820  1.00 47.89 ? 630  ARG A CZ    1 
ATOM   2649 N NH1   . ARG A 1 337 ? -28.636 74.117  42.235  1.00 43.19 ? 630  ARG A NH1   1 
ATOM   2650 N NH2   . ARG A 1 337 ? -30.360 74.586  40.797  1.00 48.07 ? 630  ARG A NH2   1 
ATOM   2651 N N     . VAL A 1 338 ? -24.235 78.112  41.836  1.00 28.30 ? 631  VAL A N     1 
ATOM   2652 C CA    . VAL A 1 338 ? -23.108 78.460  42.683  1.00 28.11 ? 631  VAL A CA    1 
ATOM   2653 C C     . VAL A 1 338 ? -22.642 79.888  42.404  1.00 27.16 ? 631  VAL A C     1 
ATOM   2654 O O     . VAL A 1 338 ? -22.481 80.669  43.351  1.00 29.52 ? 631  VAL A O     1 
ATOM   2655 C CB    . VAL A 1 338 ? -21.936 77.467  42.526  1.00 29.81 ? 631  VAL A CB    1 
ATOM   2656 C CG1   . VAL A 1 338 ? -20.665 78.012  43.147  1.00 28.94 ? 631  VAL A CG1   1 
ATOM   2657 C CG2   . VAL A 1 338 ? -22.267 76.098  43.109  1.00 31.82 ? 631  VAL A CG2   1 
ATOM   2658 N N     . PHE A 1 339 ? -22.341 80.181  41.130  1.00 25.33 ? 632  PHE A N     1 
ATOM   2659 C CA    . PHE A 1 339 ? -21.756 81.452  40.729  1.00 27.45 ? 632  PHE A CA    1 
ATOM   2660 C C     . PHE A 1 339 ? -22.810 82.568  40.796  1.00 30.69 ? 632  PHE A C     1 
ATOM   2661 O O     . PHE A 1 339 ? -22.485 83.688  41.179  1.00 31.45 ? 632  PHE A O     1 
ATOM   2662 C CB    . PHE A 1 339 ? -21.110 81.331  39.346  1.00 26.15 ? 632  PHE A CB    1 
ATOM   2663 C CG    . PHE A 1 339 ? -19.844 80.501  39.325  1.00 24.43 ? 632  PHE A CG    1 
ATOM   2664 C CD1   . PHE A 1 339 ? -18.751 80.860  40.105  1.00 23.35 ? 632  PHE A CD1   1 
ATOM   2665 C CD2   . PHE A 1 339 ? -19.737 79.369  38.530  1.00 25.29 ? 632  PHE A CD2   1 
ATOM   2666 C CE1   . PHE A 1 339 ? -17.594 80.089  40.118  1.00 24.11 ? 632  PHE A CE1   1 
ATOM   2667 C CE2   . PHE A 1 339 ? -18.583 78.588  38.558  1.00 24.05 ? 632  PHE A CE2   1 
ATOM   2668 C CZ    . PHE A 1 339 ? -17.513 78.959  39.341  1.00 23.68 ? 632  PHE A CZ    1 
ATOM   2669 N N     . GLN A 1 340 ? -24.065 82.246  40.453  1.00 32.13 ? 633  GLN A N     1 
ATOM   2670 C CA    . GLN A 1 340 ? -25.160 83.204  40.521  1.00 37.31 ? 633  GLN A CA    1 
ATOM   2671 C C     . GLN A 1 340 ? -25.330 83.670  41.965  1.00 36.30 ? 633  GLN A C     1 
ATOM   2672 O O     . GLN A 1 340 ? -25.517 84.858  42.201  1.00 36.78 ? 633  GLN A O     1 
ATOM   2673 C CB    . GLN A 1 340 ? -26.467 82.605  39.990  1.00 41.40 ? 633  GLN A CB    1 
ATOM   2674 C CG    . GLN A 1 340 ? -26.556 82.504  38.469  1.00 45.25 ? 633  GLN A CG    1 
ATOM   2675 C CD    . GLN A 1 340 ? -26.871 83.821  37.796  1.00 49.70 ? 633  GLN A CD    1 
ATOM   2676 O OE1   . GLN A 1 340 ? -27.157 84.828  38.444  1.00 53.90 ? 633  GLN A OE1   1 
ATOM   2677 N NE2   . GLN A 1 340 ? -26.828 83.823  36.475  1.00 49.91 ? 633  GLN A NE2   1 
ATOM   2678 N N     . GLU A 1 341 ? -25.176 82.749  42.928  1.00 35.01 ? 634  GLU A N     1 
ATOM   2679 C CA    . GLU A 1 341 ? -25.383 83.071  44.333  1.00 37.50 ? 634  GLU A CA    1 
ATOM   2680 C C     . GLU A 1 341 ? -24.132 83.639  45.006  1.00 36.08 ? 634  GLU A C     1 
ATOM   2681 O O     . GLU A 1 341 ? -24.182 83.994  46.173  1.00 33.61 ? 634  GLU A O     1 
ATOM   2682 C CB    . GLU A 1 341 ? -25.868 81.827  45.072  1.00 38.66 ? 634  GLU A CB    1 
ATOM   2683 C CG    . GLU A 1 341 ? -27.233 81.365  44.597  1.00 41.70 ? 634  GLU A CG    1 
ATOM   2684 C CD    . GLU A 1 341 ? -27.803 80.196  45.372  1.00 44.69 ? 634  GLU A CD    1 
ATOM   2685 O OE1   . GLU A 1 341 ? -27.101 79.695  46.277  1.00 46.67 ? 634  GLU A OE1   1 
ATOM   2686 O OE2   . GLU A 1 341 ? -28.941 79.789  45.059  1.00 49.98 ? 634  GLU A OE2   1 
ATOM   2687 N N     . GLY A 1 342 ? -23.006 83.712  44.292  1.00 35.09 ? 635  GLY A N     1 
ATOM   2688 C CA    . GLY A 1 342 ? -21.780 84.284  44.838  1.00 36.12 ? 635  GLY A CA    1 
ATOM   2689 C C     . GLY A 1 342 ? -21.063 83.356  45.818  1.00 32.98 ? 635  GLY A C     1 
ATOM   2690 O O     . GLY A 1 342 ? -20.282 83.808  46.644  1.00 34.54 ? 635  GLY A O     1 
ATOM   2691 N N     . ARG A 1 343 ? -21.342 82.057  45.756  1.00 33.18 ? 636  ARG A N     1 
ATOM   2692 C CA    . ARG A 1 343 ? -20.748 81.115  46.693  1.00 35.29 ? 636  ARG A CA    1 
ATOM   2693 C C     . ARG A 1 343 ? -19.391 80.625  46.178  1.00 32.15 ? 636  ARG A C     1 
ATOM   2694 O O     . ARG A 1 343 ? -19.007 80.865  45.039  1.00 33.79 ? 636  ARG A O     1 
ATOM   2695 C CB    . ARG A 1 343 ? -21.730 79.966  46.948  1.00 38.57 ? 636  ARG A CB    1 
ATOM   2696 C CG    . ARG A 1 343 ? -23.062 80.420  47.525  1.00 42.09 ? 636  ARG A CG    1 
ATOM   2697 C CD    . ARG A 1 343 ? -23.955 79.245  47.884  1.00 44.80 ? 636  ARG A CD    1 
ATOM   2698 N NE    . ARG A 1 343 ? -25.310 79.635  48.256  1.00 46.47 ? 636  ARG A NE    1 
ATOM   2699 C CZ    . ARG A 1 343 ? -25.672 80.156  49.429  1.00 46.29 ? 636  ARG A CZ    1 
ATOM   2700 N NH1   . ARG A 1 343 ? -24.785 80.377  50.382  1.00 38.46 ? 636  ARG A NH1   1 
ATOM   2701 N NH2   . ARG A 1 343 ? -26.942 80.459  49.644  1.00 47.26 ? 636  ARG A NH2   1 
ATOM   2702 N N     . ASP A 1 344 ? -18.659 79.939  47.056  1.00 34.61 ? 637  ASP A N     1 
ATOM   2703 C CA    . ASP A 1 344 ? -17.322 79.435  46.779  1.00 33.66 ? 637  ASP A CA    1 
ATOM   2704 C C     . ASP A 1 344 ? -17.445 78.063  46.125  1.00 30.97 ? 637  ASP A C     1 
ATOM   2705 O O     . ASP A 1 344 ? -17.882 77.114  46.765  1.00 30.75 ? 637  ASP A O     1 
ATOM   2706 C CB    . ASP A 1 344 ? -16.519 79.368  48.077  1.00 34.41 ? 637  ASP A CB    1 
ATOM   2707 C CG    . ASP A 1 344 ? -15.112 78.807  47.940  1.00 37.97 ? 637  ASP A CG    1 
ATOM   2708 O OD1   . ASP A 1 344 ? -14.929 77.778  47.258  1.00 37.75 ? 637  ASP A OD1   1 
ATOM   2709 O OD2   . ASP A 1 344 ? -14.216 79.370  48.568  1.00 45.35 ? 637  ASP A OD2   1 
ATOM   2710 N N     . ILE A 1 345 ? -17.029 77.957  44.862  1.00 28.92 ? 638  ILE A N     1 
ATOM   2711 C CA    . ILE A 1 345 ? -17.235 76.742  44.088  1.00 29.95 ? 638  ILE A CA    1 
ATOM   2712 C C     . ILE A 1 345 ? -16.604 75.533  44.794  1.00 29.41 ? 638  ILE A C     1 
ATOM   2713 O O     . ILE A 1 345 ? -17.197 74.452  44.789  1.00 28.56 ? 638  ILE A O     1 
ATOM   2714 C CB    . ILE A 1 345 ? -16.752 76.902  42.629  1.00 30.91 ? 638  ILE A CB    1 
ATOM   2715 C CG1   . ILE A 1 345 ? -16.994 75.632  41.803  1.00 33.51 ? 638  ILE A CG1   1 
ATOM   2716 C CG2   . ILE A 1 345 ? -15.297 77.331  42.543  1.00 29.68 ? 638  ILE A CG2   1 
ATOM   2717 C CD1   . ILE A 1 345 ? -18.445 75.208  41.716  1.00 34.23 ? 638  ILE A CD1   1 
ATOM   2718 N N     . HIS A 1 346 ? -15.424 75.713  45.399  1.00 26.59 ? 639  HIS A N     1 
ATOM   2719 C CA    . HIS A 1 346 ? -14.705 74.584  45.986  1.00 28.05 ? 639  HIS A CA    1 
ATOM   2720 C C     . HIS A 1 346 ? -15.377 74.123  47.272  1.00 28.48 ? 639  HIS A C     1 
ATOM   2721 O O     . HIS A 1 346 ? -15.487 72.923  47.499  1.00 29.56 ? 639  HIS A O     1 
ATOM   2722 C CB    . HIS A 1 346 ? -13.224 74.912  46.193  1.00 25.59 ? 639  HIS A CB    1 
ATOM   2723 C CG    . HIS A 1 346 ? -12.550 75.331  44.925  1.00 25.32 ? 639  HIS A CG    1 
ATOM   2724 N ND1   . HIS A 1 346 ? -12.799 74.730  43.714  1.00 25.38 ? 639  HIS A ND1   1 
ATOM   2725 C CD2   . HIS A 1 346 ? -11.734 76.401  44.688  1.00 25.20 ? 639  HIS A CD2   1 
ATOM   2726 C CE1   . HIS A 1 346 ? -12.114 75.371  42.766  1.00 26.24 ? 639  HIS A CE1   1 
ATOM   2727 N NE2   . HIS A 1 346 ? -11.437 76.415  43.354  1.00 24.38 ? 639  HIS A NE2   1 
ATOM   2728 N N     . THR A 1 347 ? -15.891 75.073  48.062  1.00 29.76 ? 640  THR A N     1 
ATOM   2729 C CA    . THR A 1 347 ? -16.618 74.744  49.276  1.00 29.95 ? 640  THR A CA    1 
ATOM   2730 C C     . THR A 1 347 ? -17.909 74.015  48.912  1.00 30.43 ? 640  THR A C     1 
ATOM   2731 O O     . THR A 1 347 ? -18.212 73.004  49.536  1.00 29.26 ? 640  THR A O     1 
ATOM   2732 C CB    . THR A 1 347 ? -16.833 75.984  50.154  1.00 32.08 ? 640  THR A CB    1 
ATOM   2733 O OG1   . THR A 1 347 ? -15.542 76.361  50.636  1.00 29.68 ? 640  THR A OG1   1 
ATOM   2734 C CG2   . THR A 1 347 ? -17.769 75.752  51.322  1.00 32.72 ? 640  THR A CG2   1 
ATOM   2735 N N     . GLU A 1 348 ? -18.644 74.504  47.898  1.00 29.75 ? 641  GLU A N     1 
ATOM   2736 C CA    . GLU A 1 348 ? -19.933 73.926  47.556  1.00 30.11 ? 641  GLU A CA    1 
ATOM   2737 C C     . GLU A 1 348 ? -19.712 72.514  47.024  1.00 31.45 ? 641  GLU A C     1 
ATOM   2738 O O     . GLU A 1 348 ? -20.396 71.583  47.451  1.00 31.92 ? 641  GLU A O     1 
ATOM   2739 C CB    . GLU A 1 348 ? -20.703 74.783  46.548  1.00 31.45 ? 641  GLU A CB    1 
ATOM   2740 C CG    . GLU A 1 348 ? -21.055 76.162  47.069  1.00 31.68 ? 641  GLU A CG    1 
ATOM   2741 C CD    . GLU A 1 348 ? -21.855 76.179  48.369  1.00 31.65 ? 641  GLU A CD    1 
ATOM   2742 O OE1   . GLU A 1 348 ? -22.952 75.606  48.392  1.00 31.50 ? 641  GLU A OE1   1 
ATOM   2743 O OE2   . GLU A 1 348 ? -21.368 76.767  49.351  1.00 30.35 ? 641  GLU A OE2   1 
ATOM   2744 N N     . THR A 1 349 ? -18.742 72.354  46.111  1.00 29.88 ? 642  THR A N     1 
ATOM   2745 C CA    . THR A 1 349 ? -18.410 71.031  45.605  1.00 29.86 ? 642  THR A CA    1 
ATOM   2746 C C     . THR A 1 349 ? -18.153 70.107  46.796  1.00 29.05 ? 642  THR A C     1 
ATOM   2747 O O     . THR A 1 349 ? -18.734 69.031  46.898  1.00 29.60 ? 642  THR A O     1 
ATOM   2748 C CB    . THR A 1 349 ? -17.238 71.083  44.617  1.00 29.65 ? 642  THR A CB    1 
ATOM   2749 O OG1   . THR A 1 349 ? -17.677 71.869  43.513  1.00 30.98 ? 642  THR A OG1   1 
ATOM   2750 C CG2   . THR A 1 349 ? -16.781 69.724  44.132  1.00 29.11 ? 642  THR A CG2   1 
ATOM   2751 N N     . ALA A 1 350 ? -17.316 70.556  47.723  1.00 29.60 ? 643  ALA A N     1 
ATOM   2752 C CA    . ALA A 1 350 ? -16.953 69.739  48.870  1.00 31.99 ? 643  ALA A CA    1 
ATOM   2753 C C     . ALA A 1 350 ? -18.178 69.372  49.706  1.00 33.24 ? 643  ALA A C     1 
ATOM   2754 O O     . ALA A 1 350 ? -18.281 68.228  50.137  1.00 32.73 ? 643  ALA A O     1 
ATOM   2755 C CB    . ALA A 1 350 ? -15.898 70.422  49.696  1.00 32.13 ? 643  ALA A CB    1 
ATOM   2756 N N     . SER A 1 351 ? -19.116 70.313  49.892  1.00 34.37 ? 644  SER A N     1 
ATOM   2757 C CA    . SER A 1 351 ? -20.301 70.081  50.703  1.00 32.46 ? 644  SER A CA    1 
ATOM   2758 C C     . SER A 1 351 ? -21.099 68.894  50.162  1.00 35.30 ? 644  SER A C     1 
ATOM   2759 O O     . SER A 1 351 ? -21.593 68.075  50.944  1.00 30.21 ? 644  SER A O     1 
ATOM   2760 C CB    . SER A 1 351 ? -21.166 71.338  50.848  1.00 33.12 ? 644  SER A CB    1 
ATOM   2761 O OG    . SER A 1 351 ? -22.011 71.542  49.731  1.00 35.89 ? 644  SER A OG    1 
ATOM   2762 N N     . TRP A 1 352 ? -21.228 68.801  48.830  1.00 34.46 ? 645  TRP A N     1 
ATOM   2763 C CA    . TRP A 1 352 ? -21.959 67.706  48.210  1.00 37.75 ? 645  TRP A CA    1 
ATOM   2764 C C     . TRP A 1 352 ? -21.077 66.460  48.130  1.00 38.49 ? 645  TRP A C     1 
ATOM   2765 O O     . TRP A 1 352 ? -21.582 65.351  48.237  1.00 34.51 ? 645  TRP A O     1 
ATOM   2766 C CB    . TRP A 1 352 ? -22.535 68.101  46.839  1.00 42.81 ? 645  TRP A CB    1 
ATOM   2767 C CG    . TRP A 1 352 ? -23.538 69.217  46.926  1.00 48.36 ? 645  TRP A CG    1 
ATOM   2768 C CD1   . TRP A 1 352 ? -24.611 69.290  47.769  1.00 52.36 ? 645  TRP A CD1   1 
ATOM   2769 C CD2   . TRP A 1 352 ? -23.542 70.449  46.180  1.00 51.65 ? 645  TRP A CD2   1 
ATOM   2770 N NE1   . TRP A 1 352 ? -25.279 70.475  47.601  1.00 52.39 ? 645  TRP A NE1   1 
ATOM   2771 C CE2   . TRP A 1 352 ? -24.641 71.209  46.636  1.00 54.29 ? 645  TRP A CE2   1 
ATOM   2772 C CE3   . TRP A 1 352 ? -22.727 70.984  45.175  1.00 58.24 ? 645  TRP A CE3   1 
ATOM   2773 C CZ2   . TRP A 1 352 ? -24.946 72.467  46.118  1.00 58.96 ? 645  TRP A CZ2   1 
ATOM   2774 C CZ3   . TRP A 1 352 ? -23.028 72.230  44.665  1.00 61.14 ? 645  TRP A CZ3   1 
ATOM   2775 C CH2   . TRP A 1 352 ? -24.121 72.961  45.135  1.00 61.70 ? 645  TRP A CH2   1 
ATOM   2776 N N     . MET A 1 353 ? -19.765 66.630  47.943  1.00 38.37 ? 646  MET A N     1 
ATOM   2777 C CA    . MET A 1 353 ? -18.877 65.480  47.812  1.00 38.76 ? 646  MET A CA    1 
ATOM   2778 C C     . MET A 1 353 ? -18.836 64.698  49.129  1.00 38.60 ? 646  MET A C     1 
ATOM   2779 O O     . MET A 1 353 ? -18.711 63.474  49.119  1.00 35.23 ? 646  MET A O     1 
ATOM   2780 C CB    . MET A 1 353 ? -17.448 65.913  47.480  1.00 39.22 ? 646  MET A CB    1 
ATOM   2781 C CG    . MET A 1 353 ? -17.269 66.480  46.086  1.00 46.26 ? 646  MET A CG    1 
ATOM   2782 S SD    . MET A 1 353 ? -17.552 65.275  44.774  1.00 53.00 ? 646  MET A SD    1 
ATOM   2783 C CE    . MET A 1 353 ? -16.694 63.846  45.438  1.00 49.95 ? 646  MET A CE    1 
ATOM   2784 N N     . PHE A 1 354 ? -18.889 65.415  50.258  1.00 38.00 ? 647  PHE A N     1 
ATOM   2785 C CA    . PHE A 1 354 ? -18.675 64.816  51.567  1.00 37.05 ? 647  PHE A CA    1 
ATOM   2786 C C     . PHE A 1 354 ? -19.961 64.864  52.386  1.00 38.77 ? 647  PHE A C     1 
ATOM   2787 O O     . PHE A 1 354 ? -19.971 64.440  53.541  1.00 44.46 ? 647  PHE A O     1 
ATOM   2788 C CB    . PHE A 1 354 ? -17.468 65.489  52.223  1.00 39.30 ? 647  PHE A CB    1 
ATOM   2789 C CG    . PHE A 1 354 ? -16.205 65.316  51.414  1.00 42.00 ? 647  PHE A CG    1 
ATOM   2790 C CD1   . PHE A 1 354 ? -15.598 64.072  51.308  1.00 43.48 ? 647  PHE A CD1   1 
ATOM   2791 C CD2   . PHE A 1 354 ? -15.666 66.371  50.689  1.00 43.11 ? 647  PHE A CD2   1 
ATOM   2792 C CE1   . PHE A 1 354 ? -14.463 63.899  50.527  1.00 44.66 ? 647  PHE A CE1   1 
ATOM   2793 C CE2   . PHE A 1 354 ? -14.532 66.198  49.907  1.00 43.74 ? 647  PHE A CE2   1 
ATOM   2794 C CZ    . PHE A 1 354 ? -13.934 64.963  49.824  1.00 45.78 ? 647  PHE A CZ    1 
ATOM   2795 N N     . GLY A 1 355 ? -21.040 65.346  51.752  1.00 36.04 ? 648  GLY A N     1 
ATOM   2796 C CA    . GLY A 1 355 ? -22.382 65.334  52.303  1.00 36.43 ? 648  GLY A CA    1 
ATOM   2797 C C     . GLY A 1 355 ? -22.451 66.035  53.655  1.00 38.94 ? 648  GLY A C     1 
ATOM   2798 O O     . GLY A 1 355 ? -23.062 65.500  54.579  1.00 40.39 ? 648  GLY A O     1 
ATOM   2799 N N     . VAL A 1 356 ? -21.774 67.191  53.757  1.00 37.61 ? 649  VAL A N     1 
ATOM   2800 C CA    . VAL A 1 356 ? -21.782 68.037  54.945  1.00 41.37 ? 649  VAL A CA    1 
ATOM   2801 C C     . VAL A 1 356 ? -22.300 69.420  54.556  1.00 42.90 ? 649  VAL A C     1 
ATOM   2802 O O     . VAL A 1 356 ? -22.076 69.860  53.428  1.00 45.28 ? 649  VAL A O     1 
ATOM   2803 C CB    . VAL A 1 356 ? -20.380 68.145  55.575  1.00 42.44 ? 649  VAL A CB    1 
ATOM   2804 C CG1   . VAL A 1 356 ? -19.938 66.826  56.198  1.00 42.44 ? 649  VAL A CG1   1 
ATOM   2805 C CG2   . VAL A 1 356 ? -19.336 68.642  54.578  1.00 42.86 ? 649  VAL A CG2   1 
ATOM   2806 N N     . PRO A 1 357 ? -22.989 70.159  55.461  1.00 42.60 ? 650  PRO A N     1 
ATOM   2807 C CA    . PRO A 1 357 ? -23.307 71.566  55.215  1.00 40.14 ? 650  PRO A CA    1 
ATOM   2808 C C     . PRO A 1 357 ? -22.015 72.340  54.971  1.00 37.53 ? 650  PRO A C     1 
ATOM   2809 O O     . PRO A 1 357 ? -20.968 71.956  55.484  1.00 34.77 ? 650  PRO A O     1 
ATOM   2810 C CB    . PRO A 1 357 ? -24.000 72.046  56.501  1.00 41.74 ? 650  PRO A CB    1 
ATOM   2811 C CG    . PRO A 1 357 ? -24.508 70.769  57.152  1.00 43.72 ? 650  PRO A CG    1 
ATOM   2812 C CD    . PRO A 1 357 ? -23.509 69.693  56.759  1.00 42.60 ? 650  PRO A CD    1 
ATOM   2813 N N     . ARG A 1 358 ? -22.107 73.435  54.205  1.00 34.83 ? 651  ARG A N     1 
ATOM   2814 C CA    . ARG A 1 358 ? -20.940 74.197  53.778  1.00 34.88 ? 651  ARG A CA    1 
ATOM   2815 C C     . ARG A 1 358 ? -20.101 74.638  54.974  1.00 35.94 ? 651  ARG A C     1 
ATOM   2816 O O     . ARG A 1 358 ? -18.876 74.682  54.884  1.00 34.05 ? 651  ARG A O     1 
ATOM   2817 C CB    . ARG A 1 358 ? -21.370 75.385  52.907  1.00 36.62 ? 651  ARG A CB    1 
ATOM   2818 C CG    . ARG A 1 358 ? -22.404 76.308  53.539  1.00 36.60 ? 651  ARG A CG    1 
ATOM   2819 C CD    . ARG A 1 358 ? -22.612 77.545  52.688  1.00 35.75 ? 651  ARG A CD    1 
ATOM   2820 N NE    . ARG A 1 358 ? -23.248 77.212  51.429  1.00 35.91 ? 651  ARG A NE    1 
ATOM   2821 C CZ    . ARG A 1 358 ? -24.556 77.050  51.252  1.00 38.11 ? 651  ARG A CZ    1 
ATOM   2822 N NH1   . ARG A 1 358 ? -25.402 77.285  52.240  1.00 38.17 ? 651  ARG A NH1   1 
ATOM   2823 N NH2   . ARG A 1 358 ? -25.020 76.662  50.079  1.00 35.73 ? 651  ARG A NH2   1 
ATOM   2824 N N     . GLU A 1 359 ? -20.763 74.909  56.108  1.00 37.42 ? 652  GLU A N     1 
ATOM   2825 C CA    . GLU A 1 359 ? -20.100 75.413  57.300  1.00 40.32 ? 652  GLU A CA    1 
ATOM   2826 C C     . GLU A 1 359 ? -19.180 74.351  57.911  1.00 39.14 ? 652  GLU A C     1 
ATOM   2827 O O     . GLU A 1 359 ? -18.242 74.692  58.628  1.00 40.69 ? 652  GLU A O     1 
ATOM   2828 C CB    . GLU A 1 359 ? -21.129 75.866  58.344  1.00 43.46 ? 652  GLU A CB    1 
ATOM   2829 C CG    . GLU A 1 359 ? -21.974 77.062  57.923  1.00 42.99 ? 652  GLU A CG    1 
ATOM   2830 C CD    . GLU A 1 359 ? -23.274 76.768  57.192  1.00 44.09 ? 652  GLU A CD    1 
ATOM   2831 O OE1   . GLU A 1 359 ? -23.932 77.734  56.786  1.00 49.88 ? 652  GLU A OE1   1 
ATOM   2832 O OE2   . GLU A 1 359 ? -23.639 75.583  57.039  1.00 47.95 ? 652  GLU A OE2   1 
ATOM   2833 N N     . ALA A 1 360 ? -19.450 73.072  57.634  1.00 36.78 ? 653  ALA A N     1 
ATOM   2834 C CA    . ALA A 1 360 ? -18.701 71.968  58.220  1.00 39.48 ? 653  ALA A CA    1 
ATOM   2835 C C     . ALA A 1 360 ? -17.557 71.503  57.316  1.00 39.70 ? 653  ALA A C     1 
ATOM   2836 O O     . ALA A 1 360 ? -16.817 70.606  57.688  1.00 39.35 ? 653  ALA A O     1 
ATOM   2837 C CB    . ALA A 1 360 ? -19.651 70.823  58.494  1.00 38.73 ? 653  ALA A CB    1 
ATOM   2838 N N     . VAL A 1 361 ? -17.427 72.073  56.115  1.00 40.15 ? 654  VAL A N     1 
ATOM   2839 C CA    . VAL A 1 361 ? -16.376 71.672  55.200  1.00 37.76 ? 654  VAL A CA    1 
ATOM   2840 C C     . VAL A 1 361 ? -15.036 72.061  55.816  1.00 38.15 ? 654  VAL A C     1 
ATOM   2841 O O     . VAL A 1 361 ? -14.839 73.217  56.168  1.00 39.67 ? 654  VAL A O     1 
ATOM   2842 C CB    . VAL A 1 361 ? -16.588 72.307  53.806  1.00 36.04 ? 654  VAL A CB    1 
ATOM   2843 C CG1   . VAL A 1 361 ? -15.364 72.175  52.916  1.00 37.23 ? 654  VAL A CG1   1 
ATOM   2844 C CG2   . VAL A 1 361 ? -17.804 71.722  53.114  1.00 35.52 ? 654  VAL A CG2   1 
ATOM   2845 N N     . ASN A 1 362 ? -14.128 71.084  55.942  1.00 39.82 ? 655  ASN A N     1 
ATOM   2846 C CA    . ASN A 1 362 ? -12.810 71.308  56.520  1.00 38.83 ? 655  ASN A CA    1 
ATOM   2847 C C     . ASN A 1 362 ? -11.781 71.464  55.397  1.00 40.58 ? 655  ASN A C     1 
ATOM   2848 O O     . ASN A 1 362 ? -12.080 71.190  54.235  1.00 41.68 ? 655  ASN A O     1 
ATOM   2849 C CB    . ASN A 1 362 ? -12.433 70.210  57.527  1.00 40.00 ? 655  ASN A CB    1 
ATOM   2850 C CG    . ASN A 1 362 ? -12.139 68.861  56.908  1.00 41.42 ? 655  ASN A CG    1 
ATOM   2851 O OD1   . ASN A 1 362 ? -11.437 68.767  55.903  1.00 42.44 ? 655  ASN A OD1   1 
ATOM   2852 N ND2   . ASN A 1 362 ? -12.684 67.804  57.489  1.00 41.00 ? 655  ASN A ND2   1 
ATOM   2853 N N     . PRO A 1 363 ? -10.565 71.976  55.707  1.00 41.41 ? 656  PRO A N     1 
ATOM   2854 C CA    . PRO A 1 363 ? -9.545  72.258  54.692  1.00 41.49 ? 656  PRO A CA    1 
ATOM   2855 C C     . PRO A 1 363 ? -9.161  71.118  53.751  1.00 41.84 ? 656  PRO A C     1 
ATOM   2856 O O     . PRO A 1 363 ? -8.845  71.361  52.594  1.00 40.14 ? 656  PRO A O     1 
ATOM   2857 C CB    . PRO A 1 363 ? -8.318  72.616  55.541  1.00 40.34 ? 656  PRO A CB    1 
ATOM   2858 C CG    . PRO A 1 363 ? -8.911  73.254  56.777  1.00 41.59 ? 656  PRO A CG    1 
ATOM   2859 C CD    . PRO A 1 363 ? -10.149 72.427  57.050  1.00 41.37 ? 656  PRO A CD    1 
ATOM   2860 N N     . LEU A 1 364 ? -9.164  69.889  54.272  1.00 39.56 ? 657  LEU A N     1 
ATOM   2861 C CA    . LEU A 1 364 ? -8.782  68.713  53.511  1.00 45.51 ? 657  LEU A CA    1 
ATOM   2862 C C     . LEU A 1 364 ? -9.854  68.443  52.460  1.00 43.48 ? 657  LEU A C     1 
ATOM   2863 O O     . LEU A 1 364 ? -9.549  68.097  51.323  1.00 37.95 ? 657  LEU A O     1 
ATOM   2864 C CB    . LEU A 1 364 ? -8.622  67.537  54.485  1.00 44.87 ? 657  LEU A CB    1 
ATOM   2865 C CG    . LEU A 1 364 ? -8.228  66.191  53.880  1.00 46.36 ? 657  LEU A CG    1 
ATOM   2866 C CD1   . LEU A 1 364 ? -6.902  66.280  53.143  1.00 47.40 ? 657  LEU A CD1   1 
ATOM   2867 C CD2   . LEU A 1 364 ? -8.152  65.128  54.970  1.00 45.86 ? 657  LEU A CD2   1 
ATOM   2868 N N     . MET A 1 365 ? -11.111 68.636  52.864  1.00 38.29 ? 658  MET A N     1 
ATOM   2869 C CA    . MET A 1 365 ? -12.244 68.426  51.986  1.00 39.23 ? 658  MET A CA    1 
ATOM   2870 C C     . MET A 1 365 ? -12.231 69.458  50.857  1.00 35.65 ? 658  MET A C     1 
ATOM   2871 O O     . MET A 1 365 ? -12.506 69.109  49.718  1.00 35.16 ? 658  MET A O     1 
ATOM   2872 C CB    . MET A 1 365 ? -13.559 68.572  52.748  1.00 39.71 ? 658  MET A CB    1 
ATOM   2873 C CG    . MET A 1 365 ? -13.899 67.403  53.638  1.00 40.58 ? 658  MET A CG    1 
ATOM   2874 S SD    . MET A 1 365 ? -15.297 67.867  54.680  1.00 39.08 ? 658  MET A SD    1 
ATOM   2875 C CE    . MET A 1 365 ? -15.256 66.548  55.897  1.00 41.05 ? 658  MET A CE    1 
ATOM   2876 N N     . ARG A 1 366 ? -11.949 70.725  51.180  1.00 35.08 ? 659  ARG A N     1 
ATOM   2877 C CA    . ARG A 1 366 ? -11.967 71.773  50.173  1.00 37.82 ? 659  ARG A CA    1 
ATOM   2878 C C     . ARG A 1 366 ? -10.854 71.539  49.153  1.00 39.71 ? 659  ARG A C     1 
ATOM   2879 O O     . ARG A 1 366 ? -11.043 71.794  47.967  1.00 37.18 ? 659  ARG A O     1 
ATOM   2880 C CB    . ARG A 1 366 ? -11.808 73.166  50.786  1.00 37.55 ? 659  ARG A CB    1 
ATOM   2881 C CG    . ARG A 1 366 ? -12.039 74.292  49.787  1.00 38.21 ? 659  ARG A CG    1 
ATOM   2882 C CD    . ARG A 1 366 ? -11.955 75.662  50.431  1.00 40.09 ? 659  ARG A CD    1 
ATOM   2883 N NE    . ARG A 1 366 ? -12.263 76.747  49.506  1.00 37.95 ? 659  ARG A NE    1 
ATOM   2884 C CZ    . ARG A 1 366 ? -11.400 77.303  48.661  1.00 38.29 ? 659  ARG A CZ    1 
ATOM   2885 N NH1   . ARG A 1 366 ? -10.196 76.789  48.489  1.00 34.70 ? 659  ARG A NH1   1 
ATOM   2886 N NH2   . ARG A 1 366 ? -11.752 78.378  47.980  1.00 36.55 ? 659  ARG A NH2   1 
ATOM   2887 N N     . ARG A 1 367 ? -9.687  71.078  49.616  1.00 42.04 ? 660  ARG A N     1 
ATOM   2888 C CA    . ARG A 1 367 ? -8.551  70.934  48.724  1.00 44.30 ? 660  ARG A CA    1 
ATOM   2889 C C     . ARG A 1 367 ? -8.831  69.763  47.773  1.00 39.49 ? 660  ARG A C     1 
ATOM   2890 O O     . ARG A 1 367 ? -8.476  69.832  46.602  1.00 35.93 ? 660  ARG A O     1 
ATOM   2891 C CB    . ARG A 1 367 ? -7.243  70.870  49.525  1.00 51.80 ? 660  ARG A CB    1 
ATOM   2892 C CG    . ARG A 1 367 ? -6.565  69.508  49.599  1.00 60.12 ? 660  ARG A CG    1 
ATOM   2893 C CD    . ARG A 1 367 ? -5.640  69.225  48.425  1.00 65.82 ? 660  ARG A CD    1 
ATOM   2894 N NE    . ARG A 1 367 ? -5.180  67.840  48.352  1.00 73.42 ? 660  ARG A NE    1 
ATOM   2895 C CZ    . ARG A 1 367 ? -4.369  67.251  49.228  1.00 78.18 ? 660  ARG A CZ    1 
ATOM   2896 N NH1   . ARG A 1 367 ? -3.968  66.008  49.023  1.00 80.24 ? 660  ARG A NH1   1 
ATOM   2897 N NH2   . ARG A 1 367 ? -3.956  67.901  50.303  1.00 79.46 ? 660  ARG A NH2   1 
ATOM   2898 N N     . ALA A 1 368 ? -9.512  68.714  48.248  1.00 32.49 ? 661  ALA A N     1 
ATOM   2899 C CA    . ALA A 1 368 ? -9.931  67.613  47.388  1.00 33.84 ? 661  ALA A CA    1 
ATOM   2900 C C     . ALA A 1 368 ? -10.944 68.067  46.325  1.00 32.66 ? 661  ALA A C     1 
ATOM   2901 O O     . ALA A 1 368 ? -10.830 67.720  45.147  1.00 32.44 ? 661  ALA A O     1 
ATOM   2902 C CB    . ALA A 1 368 ? -10.496 66.500  48.233  1.00 36.41 ? 661  ALA A CB    1 
ATOM   2903 N N     . ALA A 1 369 ? -11.948 68.848  46.733  1.00 30.30 ? 662  ALA A N     1 
ATOM   2904 C CA    . ALA A 1 369 ? -12.959 69.349  45.813  1.00 28.41 ? 662  ALA A CA    1 
ATOM   2905 C C     . ALA A 1 369 ? -12.317 70.228  44.732  1.00 27.11 ? 662  ALA A C     1 
ATOM   2906 O O     . ALA A 1 369 ? -12.679 70.144  43.562  1.00 27.91 ? 662  ALA A O     1 
ATOM   2907 C CB    . ALA A 1 369 ? -14.004 70.116  46.593  1.00 28.24 ? 662  ALA A CB    1 
ATOM   2908 N N     . LYS A 1 370 ? -11.352 71.055  45.147  1.00 26.75 ? 663  LYS A N     1 
ATOM   2909 C CA    . LYS A 1 370 ? -10.622 71.941  44.260  1.00 29.02 ? 663  LYS A CA    1 
ATOM   2910 C C     . LYS A 1 370 ? -9.862  71.119  43.218  1.00 29.02 ? 663  LYS A C     1 
ATOM   2911 O O     . LYS A 1 370 ? -9.974  71.391  42.028  1.00 29.62 ? 663  LYS A O     1 
ATOM   2912 C CB    . LYS A 1 370 ? -9.711  72.824  45.114  1.00 30.80 ? 663  LYS A CB    1 
ATOM   2913 C CG    . LYS A 1 370 ? -8.992  73.917  44.352  1.00 33.21 ? 663  LYS A CG    1 
ATOM   2914 C CD    . LYS A 1 370 ? -8.216  74.844  45.237  1.00 34.43 ? 663  LYS A CD    1 
ATOM   2915 C CE    . LYS A 1 370 ? -7.330  75.779  44.441  1.00 35.70 ? 663  LYS A CE    1 
ATOM   2916 N NZ    . LYS A 1 370 ? -6.641  76.732  45.342  1.00 37.86 ? 663  LYS A NZ    1 
ATOM   2917 N N     . THR A 1 371 ? -9.148  70.071  43.662  1.00 29.48 ? 664  THR A N     1 
ATOM   2918 C CA    . THR A 1 371 ? -8.471  69.139  42.770  1.00 32.60 ? 664  THR A CA    1 
ATOM   2919 C C     . THR A 1 371 ? -9.456  68.525  41.782  1.00 32.47 ? 664  THR A C     1 
ATOM   2920 O O     . THR A 1 371 ? -9.176  68.432  40.587  1.00 32.73 ? 664  THR A O     1 
ATOM   2921 C CB    . THR A 1 371 ? -7.749  68.028  43.551  1.00 36.03 ? 664  THR A CB    1 
ATOM   2922 O OG1   . THR A 1 371 ? -6.739  68.643  44.344  1.00 36.56 ? 664  THR A OG1   1 
ATOM   2923 C CG2   . THR A 1 371 ? -7.092  66.989  42.672  1.00 37.90 ? 664  THR A CG2   1 
ATOM   2924 N N     . ILE A 1 372 ? -10.621 68.108  42.281  1.00 31.66 ? 665  ILE A N     1 
ATOM   2925 C CA    . ILE A 1 372 ? -11.621 67.504  41.415  1.00 32.74 ? 665  ILE A CA    1 
ATOM   2926 C C     . ILE A 1 372 ? -12.177 68.548  40.435  1.00 28.66 ? 665  ILE A C     1 
ATOM   2927 O O     . ILE A 1 372 ? -12.388 68.248  39.265  1.00 27.89 ? 665  ILE A O     1 
ATOM   2928 C CB    . ILE A 1 372 ? -12.728 66.845  42.261  1.00 35.77 ? 665  ILE A CB    1 
ATOM   2929 C CG1   . ILE A 1 372 ? -12.207 65.622  43.024  1.00 42.43 ? 665  ILE A CG1   1 
ATOM   2930 C CG2   . ILE A 1 372 ? -13.923 66.494  41.391  1.00 39.05 ? 665  ILE A CG2   1 
ATOM   2931 C CD1   . ILE A 1 372 ? -13.093 65.176  44.176  1.00 42.80 ? 665  ILE A CD1   1 
ATOM   2932 N N     . ASN A 1 373 ? -12.438 69.765  40.919  1.00 26.59 ? 666  ASN A N     1 
ATOM   2933 C CA    . ASN A 1 373 ? -13.066 70.803  40.110  1.00 28.34 ? 666  ASN A CA    1 
ATOM   2934 C C     . ASN A 1 373 ? -12.207 71.111  38.886  1.00 30.15 ? 666  ASN A C     1 
ATOM   2935 O O     . ASN A 1 373 ? -12.735 71.212  37.787  1.00 31.62 ? 666  ASN A O     1 
ATOM   2936 C CB    . ASN A 1 373 ? -13.317 72.087  40.906  1.00 26.72 ? 666  ASN A CB    1 
ATOM   2937 C CG    . ASN A 1 373 ? -14.638 72.104  41.646  1.00 26.75 ? 666  ASN A CG    1 
ATOM   2938 O OD1   . ASN A 1 373 ? -14.775 72.775  42.665  1.00 30.01 ? 666  ASN A OD1   1 
ATOM   2939 N ND2   . ASN A 1 373 ? -15.607 71.356  41.156  1.00 26.05 ? 666  ASN A ND2   1 
ATOM   2940 N N     . PHE A 1 374 ? -10.887 71.255  39.084  1.00 29.46 ? 667  PHE A N     1 
ATOM   2941 C CA    . PHE A 1 374 ? -9.986  71.549  37.987  1.00 29.97 ? 667  PHE A CA    1 
ATOM   2942 C C     . PHE A 1 374 ? -9.737  70.300  37.151  1.00 30.30 ? 667  PHE A C     1 
ATOM   2943 O O     . PHE A 1 374 ? -9.520  70.406  35.944  1.00 32.98 ? 667  PHE A O     1 
ATOM   2944 C CB    . PHE A 1 374 ? -8.720  72.241  38.506  1.00 29.72 ? 667  PHE A CB    1 
ATOM   2945 C CG    . PHE A 1 374 ? -9.007  73.661  38.914  1.00 28.37 ? 667  PHE A CG    1 
ATOM   2946 C CD1   . PHE A 1 374 ? -9.464  74.576  37.971  1.00 29.73 ? 667  PHE A CD1   1 
ATOM   2947 C CD2   . PHE A 1 374 ? -8.942  74.059  40.239  1.00 29.59 ? 667  PHE A CD2   1 
ATOM   2948 C CE1   . PHE A 1 374 ? -9.792  75.873  38.337  1.00 29.46 ? 667  PHE A CE1   1 
ATOM   2949 C CE2   . PHE A 1 374 ? -9.258  75.359  40.600  1.00 29.42 ? 667  PHE A CE2   1 
ATOM   2950 C CZ    . PHE A 1 374 ? -9.688  76.262  39.650  1.00 28.81 ? 667  PHE A CZ    1 
ATOM   2951 N N     . GLY A 1 375 ? -9.844  69.116  37.759  1.00 29.26 ? 668  GLY A N     1 
ATOM   2952 C CA    . GLY A 1 375 ? -9.618  67.882  37.018  1.00 29.77 ? 668  GLY A CA    1 
ATOM   2953 C C     . GLY A 1 375 ? -10.653 67.644  35.929  1.00 31.39 ? 668  GLY A C     1 
ATOM   2954 O O     . GLY A 1 375 ? -10.363 66.985  34.935  1.00 30.15 ? 668  GLY A O     1 
ATOM   2955 N N     . VAL A 1 376 ? -11.861 68.196  36.125  1.00 32.81 ? 669  VAL A N     1 
ATOM   2956 C CA    . VAL A 1 376 ? -12.961 67.988  35.203  1.00 36.33 ? 669  VAL A CA    1 
ATOM   2957 C C     . VAL A 1 376 ? -12.680 68.710  33.877  1.00 35.45 ? 669  VAL A C     1 
ATOM   2958 O O     . VAL A 1 376 ? -13.133 68.278  32.813  1.00 33.45 ? 669  VAL A O     1 
ATOM   2959 C CB    . VAL A 1 376 ? -14.293 68.422  35.847  1.00 39.73 ? 669  VAL A CB    1 
ATOM   2960 C CG1   . VAL A 1 376 ? -14.571 69.910  35.678  1.00 40.59 ? 669  VAL A CG1   1 
ATOM   2961 C CG2   . VAL A 1 376 ? -15.452 67.608  35.311  1.00 44.22 ? 669  VAL A CG2   1 
ATOM   2962 N N     . LEU A 1 377 ? -11.878 69.779  33.933  1.00 32.70 ? 670  LEU A N     1 
ATOM   2963 C CA    . LEU A 1 377 ? -11.486 70.521  32.742  1.00 31.95 ? 670  LEU A CA    1 
ATOM   2964 C C     . LEU A 1 377 ? -10.619 69.673  31.806  1.00 31.81 ? 670  LEU A C     1 
ATOM   2965 O O     . LEU A 1 377 ? -10.434 70.026  30.636  1.00 33.31 ? 670  LEU A O     1 
ATOM   2966 C CB    . LEU A 1 377 ? -10.750 71.799  33.167  1.00 31.48 ? 670  LEU A CB    1 
ATOM   2967 C CG    . LEU A 1 377 ? -11.570 72.797  33.990  1.00 32.35 ? 670  LEU A CG    1 
ATOM   2968 C CD1   . LEU A 1 377 ? -10.769 74.067  34.273  1.00 29.82 ? 670  LEU A CD1   1 
ATOM   2969 C CD2   . LEU A 1 377 ? -12.883 73.134  33.295  1.00 31.82 ? 670  LEU A CD2   1 
ATOM   2970 N N     . TYR A 1 378 ? -10.090 68.554  32.313  1.00 33.77 ? 671  TYR A N     1 
ATOM   2971 C CA    . TYR A 1 378 ? -9.311  67.636  31.498  1.00 34.05 ? 671  TYR A CA    1 
ATOM   2972 C C     . TYR A 1 378 ? -10.012 66.276  31.400  1.00 39.52 ? 671  TYR A C     1 
ATOM   2973 O O     . TYR A 1 378 ? -9.360  65.246  31.212  1.00 37.65 ? 671  TYR A O     1 
ATOM   2974 C CB    . TYR A 1 378 ? -7.894  67.586  32.072  1.00 33.49 ? 671  TYR A CB    1 
ATOM   2975 C CG    . TYR A 1 378 ? -7.279  68.956  32.236  1.00 34.41 ? 671  TYR A CG    1 
ATOM   2976 C CD1   . TYR A 1 378 ? -6.805  69.658  31.136  1.00 34.83 ? 671  TYR A CD1   1 
ATOM   2977 C CD2   . TYR A 1 378 ? -7.232  69.588  33.470  1.00 33.37 ? 671  TYR A CD2   1 
ATOM   2978 C CE1   . TYR A 1 378 ? -6.248  70.924  31.263  1.00 34.16 ? 671  TYR A CE1   1 
ATOM   2979 C CE2   . TYR A 1 378 ? -6.692  70.860  33.615  1.00 34.14 ? 671  TYR A CE2   1 
ATOM   2980 C CZ    . TYR A 1 378 ? -6.205  71.538  32.502  1.00 35.19 ? 671  TYR A CZ    1 
ATOM   2981 O OH    . TYR A 1 378 ? -5.668  72.806  32.609  1.00 33.70 ? 671  TYR A OH    1 
ATOM   2982 N N     . GLY A 1 379 ? -11.348 66.283  31.533  1.00 39.37 ? 672  GLY A N     1 
ATOM   2983 C CA    . GLY A 1 379 ? -12.164 65.115  31.237  1.00 42.75 ? 672  GLY A CA    1 
ATOM   2984 C C     . GLY A 1 379 ? -12.405 64.183  32.426  1.00 45.74 ? 672  GLY A C     1 
ATOM   2985 O O     . GLY A 1 379 ? -13.025 63.136  32.246  1.00 47.00 ? 672  GLY A O     1 
ATOM   2986 N N     . MET A 1 380 ? -11.915 64.548  33.619  1.00 48.67 ? 673  MET A N     1 
ATOM   2987 C CA    . MET A 1 380 ? -12.161 63.783  34.839  1.00 51.35 ? 673  MET A CA    1 
ATOM   2988 C C     . MET A 1 380 ? -11.557 62.379  34.767  1.00 54.36 ? 673  MET A C     1 
ATOM   2989 O O     . MET A 1 380 ? -12.292 61.395  34.710  1.00 57.41 ? 673  MET A O     1 
ATOM   2990 C CB    . MET A 1 380 ? -13.663 63.669  35.125  1.00 51.74 ? 673  MET A CB    1 
ATOM   2991 C CG    . MET A 1 380 ? -13.991 63.593  36.608  1.00 54.88 ? 673  MET A CG    1 
ATOM   2992 S SD    . MET A 1 380 ? -13.536 65.104  37.480  1.00 52.67 ? 673  MET A SD    1 
ATOM   2993 C CE    . MET A 1 380 ? -12.111 64.549  38.417  1.00 62.98 ? 673  MET A CE    1 
ATOM   2994 N N     . SER A 1 381 ? -10.219 62.284  34.812  1.00 52.75 ? 674  SER A N     1 
ATOM   2995 C CA    . SER A 1 381 ? -9.547  60.993  34.865  1.00 54.23 ? 674  SER A CA    1 
ATOM   2996 C C     . SER A 1 381 ? -9.586  60.423  36.281  1.00 55.28 ? 674  SER A C     1 
ATOM   2997 O O     . SER A 1 381 ? -9.104  61.065  37.211  1.00 53.94 ? 674  SER A O     1 
ATOM   2998 C CB    . SER A 1 381 ? -8.122  61.087  34.395  1.00 58.23 ? 674  SER A CB    1 
ATOM   2999 O OG    . SER A 1 381 ? -7.357  60.013  34.928  1.00 55.05 ? 674  SER A OG    1 
ATOM   3000 N N     . ALA A 1 382 ? -10.109 59.195  36.419  1.00 57.27 ? 675  ALA A N     1 
ATOM   3001 C CA    . ALA A 1 382 ? -10.207 58.517  37.706  1.00 57.96 ? 675  ALA A CA    1 
ATOM   3002 C C     . ALA A 1 382 ? -8.825  58.116  38.212  1.00 56.13 ? 675  ALA A C     1 
ATOM   3003 O O     . ALA A 1 382 ? -8.581  58.130  39.418  1.00 51.11 ? 675  ALA A O     1 
ATOM   3004 C CB    . ALA A 1 382 ? -11.113 57.311  37.595  1.00 60.70 ? 675  ALA A CB    1 
ATOM   3005 N N     . HIS A 1 383 ? -7.926  57.758  37.287  1.00 61.55 ? 676  HIS A N     1 
ATOM   3006 C CA    . HIS A 1 383 ? -6.610  57.278  37.674  1.00 65.38 ? 676  HIS A CA    1 
ATOM   3007 C C     . HIS A 1 383 ? -5.771  58.439  38.200  1.00 61.30 ? 676  HIS A C     1 
ATOM   3008 O O     . HIS A 1 383 ? -5.026  58.279  39.163  1.00 58.50 ? 676  HIS A O     1 
ATOM   3009 C CB    . HIS A 1 383 ? -5.912  56.560  36.512  1.00 71.33 ? 676  HIS A CB    1 
ATOM   3010 C CG    . HIS A 1 383 ? -4.709  55.774  36.938  1.00 79.15 ? 676  HIS A CG    1 
ATOM   3011 N ND1   . HIS A 1 383 ? -3.505  56.342  37.283  1.00 85.45 ? 676  HIS A ND1   1 
ATOM   3012 C CD2   . HIS A 1 383 ? -4.571  54.427  37.097  1.00 84.20 ? 676  HIS A CD2   1 
ATOM   3013 C CE1   . HIS A 1 383 ? -2.649  55.384  37.629  1.00 85.10 ? 676  HIS A CE1   1 
ATOM   3014 N NE2   . HIS A 1 383 ? -3.292  54.186  37.522  1.00 90.84 ? 676  HIS A NE2   1 
ATOM   3015 N N     . ARG A 1 384 ? -5.904  59.609  37.566  1.00 60.27 ? 677  ARG A N     1 
ATOM   3016 C CA    . ARG A 1 384 ? -5.132  60.772  37.972  1.00 58.60 ? 677  ARG A CA    1 
ATOM   3017 C C     . ARG A 1 384 ? -5.698  61.314  39.285  1.00 52.73 ? 677  ARG A C     1 
ATOM   3018 O O     . ARG A 1 384 ? -4.958  61.898  40.070  1.00 49.21 ? 677  ARG A O     1 
ATOM   3019 C CB    . ARG A 1 384 ? -5.123  61.828  36.862  1.00 67.25 ? 677  ARG A CB    1 
ATOM   3020 C CG    . ARG A 1 384 ? -3.735  62.368  36.536  1.00 75.83 ? 677  ARG A CG    1 
ATOM   3021 C CD    . ARG A 1 384 ? -3.717  63.566  35.600  1.00 82.48 ? 677  ARG A CD    1 
ATOM   3022 N NE    . ARG A 1 384 ? -4.745  63.546  34.563  1.00 89.75 ? 677  ARG A NE    1 
ATOM   3023 C CZ    . ARG A 1 384 ? -4.782  64.372  33.521  1.00 95.76 ? 677  ARG A CZ    1 
ATOM   3024 N NH1   . ARG A 1 384 ? -3.660  64.740  32.925  1.00 95.34 ? 677  ARG A NH1   1 
ATOM   3025 N NH2   . ARG A 1 384 ? -5.945  64.790  33.052  1.00 93.25 ? 677  ARG A NH2   1 
ATOM   3026 N N     . LEU A 1 385 ? -7.000  61.098  39.541  1.00 48.24 ? 678  LEU A N     1 
ATOM   3027 C CA    . LEU A 1 385 ? -7.603  61.552  40.792  1.00 49.61 ? 678  LEU A CA    1 
ATOM   3028 C C     . LEU A 1 385 ? -7.067  60.723  41.965  1.00 48.22 ? 678  LEU A C     1 
ATOM   3029 O O     . LEU A 1 385 ? -6.705  61.281  42.999  1.00 46.06 ? 678  LEU A O     1 
ATOM   3030 C CB    . LEU A 1 385 ? -9.135  61.495  40.701  1.00 46.92 ? 678  LEU A CB    1 
ATOM   3031 C CG    . LEU A 1 385 ? -9.885  61.976  41.946  1.00 44.81 ? 678  LEU A CG    1 
ATOM   3032 C CD1   . LEU A 1 385 ? -9.443  63.378  42.351  1.00 46.13 ? 678  LEU A CD1   1 
ATOM   3033 C CD2   . LEU A 1 385 ? -11.386 61.951  41.727  1.00 42.93 ? 678  LEU A CD2   1 
ATOM   3034 N N     . SER A 1 386 ? -6.968  59.396  41.783  1.00 55.75 ? 679  SER A N     1 
ATOM   3035 C CA    . SER A 1 386 ? -6.452  58.513  42.821  1.00 56.51 ? 679  SER A CA    1 
ATOM   3036 C C     . SER A 1 386 ? -5.048  58.932  43.254  1.00 52.79 ? 679  SER A C     1 
ATOM   3037 O O     . SER A 1 386 ? -4.732  58.859  44.436  1.00 50.45 ? 679  SER A O     1 
ATOM   3038 C CB    . SER A 1 386 ? -6.493  57.063  42.394  1.00 59.17 ? 679  SER A CB    1 
ATOM   3039 O OG    . SER A 1 386 ? -6.082  56.918  41.044  1.00 65.91 ? 679  SER A OG    1 
ATOM   3040 N N     . GLN A 1 387 ? -4.214  59.396  42.311  1.00 59.38 ? 680  GLN A N     1 
ATOM   3041 C CA    . GLN A 1 387 ? -2.827  59.740  42.613  1.00 60.55 ? 680  GLN A CA    1 
ATOM   3042 C C     . GLN A 1 387 ? -2.738  61.048  43.403  1.00 55.62 ? 680  GLN A C     1 
ATOM   3043 O O     . GLN A 1 387 ? -2.041  61.127  44.408  1.00 50.58 ? 680  GLN A O     1 
ATOM   3044 C CB    . GLN A 1 387 ? -2.001  59.850  41.329  1.00 67.45 ? 680  GLN A CB    1 
ATOM   3045 C CG    . GLN A 1 387 ? -1.972  58.565  40.515  1.00 74.78 ? 680  GLN A CG    1 
ATOM   3046 C CD    . GLN A 1 387 ? -0.891  58.578  39.461  1.00 81.98 ? 680  GLN A CD    1 
ATOM   3047 O OE1   . GLN A 1 387 ? 0.293   58.449  39.764  1.00 86.92 ? 680  GLN A OE1   1 
ATOM   3048 N NE2   . GLN A 1 387 ? -1.295  58.723  38.208  1.00 82.58 ? 680  GLN A NE2   1 
ATOM   3049 N N     . LYS A 1 388 ? -3.443  62.085  42.944  1.00 54.89 ? 681  LYS A N     1 
ATOM   3050 C CA    . LYS A 1 388 ? -3.309  63.411  43.527  1.00 51.30 ? 681  LYS A CA    1 
ATOM   3051 C C     . LYS A 1 388 ? -3.802  63.419  44.974  1.00 49.76 ? 681  LYS A C     1 
ATOM   3052 O O     . LYS A 1 388 ? -3.233  64.122  45.807  1.00 49.71 ? 681  LYS A O     1 
ATOM   3053 C CB    . LYS A 1 388 ? -4.054  64.429  42.662  1.00 50.85 ? 681  LYS A CB    1 
ATOM   3054 C CG    . LYS A 1 388 ? -3.464  64.593  41.268  1.00 52.00 ? 681  LYS A CG    1 
ATOM   3055 C CD    . LYS A 1 388 ? -3.961  65.819  40.519  1.00 51.46 ? 681  LYS A CD    1 
ATOM   3056 C CE    . LYS A 1 388 ? -3.240  66.029  39.204  1.00 49.73 ? 681  LYS A CE    1 
ATOM   3057 N NZ    . LYS A 1 388 ? -1.826  66.415  39.410  1.00 50.34 ? 681  LYS A NZ    1 
ATOM   3058 N N     . LEU A 1 389 ? -4.858  62.642  45.255  1.00 50.79 ? 682  LEU A N     1 
ATOM   3059 C CA    . LEU A 1 389 ? -5.461  62.568  46.580  1.00 49.76 ? 682  LEU A CA    1 
ATOM   3060 C C     . LEU A 1 389 ? -4.892  61.412  47.402  1.00 53.62 ? 682  LEU A C     1 
ATOM   3061 O O     . LEU A 1 389 ? -5.132  61.363  48.608  1.00 52.53 ? 682  LEU A O     1 
ATOM   3062 C CB    . LEU A 1 389 ? -6.973  62.397  46.416  1.00 49.14 ? 682  LEU A CB    1 
ATOM   3063 C CG    . LEU A 1 389 ? -7.708  63.582  45.793  1.00 47.26 ? 682  LEU A CG    1 
ATOM   3064 C CD1   . LEU A 1 389 ? -9.216  63.384  45.875  1.00 47.33 ? 682  LEU A CD1   1 
ATOM   3065 C CD2   . LEU A 1 389 ? -7.294  64.887  46.456  1.00 45.92 ? 682  LEU A CD2   1 
ATOM   3066 N N     . ALA A 1 390 ? -4.159  60.494  46.750  1.00 54.15 ? 683  ALA A N     1 
ATOM   3067 C CA    . ALA A 1 390 ? -3.545  59.345  47.406  1.00 53.62 ? 683  ALA A CA    1 
ATOM   3068 C C     . ALA A 1 390 ? -4.620  58.462  48.040  1.00 53.07 ? 683  ALA A C     1 
ATOM   3069 O O     . ALA A 1 390 ? -4.619  58.236  49.246  1.00 53.42 ? 683  ALA A O     1 
ATOM   3070 C CB    . ALA A 1 390 ? -2.525  59.807  48.421  1.00 53.44 ? 683  ALA A CB    1 
ATOM   3071 N N     . ILE A 1 391 ? -5.545  57.978  47.208  1.00 53.85 ? 684  ILE A N     1 
ATOM   3072 C CA    . ILE A 1 391 ? -6.668  57.170  47.663  1.00 54.30 ? 684  ILE A CA    1 
ATOM   3073 C C     . ILE A 1 391 ? -6.844  56.022  46.677  1.00 52.38 ? 684  ILE A C     1 
ATOM   3074 O O     . ILE A 1 391 ? -6.485  56.154  45.508  1.00 52.52 ? 684  ILE A O     1 
ATOM   3075 C CB    . ILE A 1 391 ? -7.976  57.990  47.786  1.00 53.71 ? 684  ILE A CB    1 
ATOM   3076 C CG1   . ILE A 1 391 ? -8.354  58.674  46.465  1.00 53.69 ? 684  ILE A CG1   1 
ATOM   3077 C CG2   . ILE A 1 391 ? -7.898  58.984  48.937  1.00 55.71 ? 684  ILE A CG2   1 
ATOM   3078 C CD1   . ILE A 1 391 ? -9.717  59.343  46.466  1.00 52.10 ? 684  ILE A CD1   1 
ATOM   3079 N N     . PRO A 1 392 ? -7.427  54.879  47.105  1.00 54.54 ? 685  PRO A N     1 
ATOM   3080 C CA    . PRO A 1 392 ? -7.725  53.782  46.183  1.00 53.85 ? 685  PRO A CA    1 
ATOM   3081 C C     . PRO A 1 392 ? -8.392  54.269  44.897  1.00 54.39 ? 685  PRO A C     1 
ATOM   3082 O O     . PRO A 1 392 ? -9.184  55.210  44.922  1.00 57.47 ? 685  PRO A O     1 
ATOM   3083 C CB    . PRO A 1 392 ? -8.662  52.878  47.003  1.00 53.29 ? 685  PRO A CB    1 
ATOM   3084 C CG    . PRO A 1 392 ? -8.250  53.125  48.449  1.00 53.17 ? 685  PRO A CG    1 
ATOM   3085 C CD    . PRO A 1 392 ? -7.823  54.578  48.493  1.00 53.04 ? 685  PRO A CD    1 
ATOM   3086 N N     . TYR A 1 393 ? -8.049  53.610  43.784  1.00 53.90 ? 686  TYR A N     1 
ATOM   3087 C CA    . TYR A 1 393 ? -8.645  53.850  42.478  1.00 54.10 ? 686  TYR A CA    1 
ATOM   3088 C C     . TYR A 1 393 ? -10.175 53.793  42.536  1.00 55.61 ? 686  TYR A C     1 
ATOM   3089 O O     . TYR A 1 393 ? -10.844 54.583  41.866  1.00 50.84 ? 686  TYR A O     1 
ATOM   3090 C CB    . TYR A 1 393 ? -8.114  52.822  41.474  1.00 54.17 ? 686  TYR A CB    1 
ATOM   3091 C CG    . TYR A 1 393 ? -8.640  52.986  40.071  1.00 56.19 ? 686  TYR A CG    1 
ATOM   3092 C CD1   . TYR A 1 393 ? -8.153  53.980  39.234  1.00 57.13 ? 686  TYR A CD1   1 
ATOM   3093 C CD2   . TYR A 1 393 ? -9.654  52.170  39.589  1.00 57.98 ? 686  TYR A CD2   1 
ATOM   3094 C CE1   . TYR A 1 393 ? -8.646  54.143  37.947  1.00 59.26 ? 686  TYR A CE1   1 
ATOM   3095 C CE2   . TYR A 1 393 ? -10.160 52.322  38.307  1.00 56.41 ? 686  TYR A CE2   1 
ATOM   3096 C CZ    . TYR A 1 393 ? -9.652  53.311  37.483  1.00 58.54 ? 686  TYR A CZ    1 
ATOM   3097 O OH    . TYR A 1 393 ? -10.151 53.462  36.209  1.00 60.98 ? 686  TYR A OH    1 
ATOM   3098 N N     . GLU A 1 394 ? -10.721 52.841  43.313  1.00 53.50 ? 687  GLU A N     1 
ATOM   3099 C CA    . GLU A 1 394 ? -12.158 52.602  43.372  1.00 54.46 ? 687  GLU A CA    1 
ATOM   3100 C C     . GLU A 1 394 ? -12.863 53.705  44.168  1.00 49.45 ? 687  GLU A C     1 
ATOM   3101 O O     . GLU A 1 394 ? -14.043 53.969  43.934  1.00 51.25 ? 687  GLU A O     1 
ATOM   3102 C CB    . GLU A 1 394 ? -12.449 51.216  43.964  1.00 52.72 ? 687  GLU A CB    1 
ATOM   3103 N N     . GLU A 1 395 ? -12.147 54.334  45.112  1.00 49.69 ? 688  GLU A N     1 
ATOM   3104 C CA    . GLU A 1 395 ? -12.677 55.465  45.864  1.00 52.96 ? 688  GLU A CA    1 
ATOM   3105 C C     . GLU A 1 395 ? -12.622 56.731  45.008  1.00 54.30 ? 688  GLU A C     1 
ATOM   3106 O O     . GLU A 1 395 ? -13.448 57.619  45.189  1.00 47.57 ? 688  GLU A O     1 
ATOM   3107 C CB    . GLU A 1 395 ? -11.931 55.666  47.188  1.00 58.06 ? 688  GLU A CB    1 
ATOM   3108 C CG    . GLU A 1 395 ? -12.618 55.018  48.386  1.00 62.67 ? 688  GLU A CG    1 
ATOM   3109 C CD    . GLU A 1 395 ? -13.902 55.704  48.826  1.00 64.79 ? 688  GLU A CD    1 
ATOM   3110 O OE1   . GLU A 1 395 ? -14.980 55.085  48.701  1.00 72.25 ? 688  GLU A OE1   1 
ATOM   3111 O OE2   . GLU A 1 395 ? -13.827 56.860  49.288  1.00 66.74 ? 688  GLU A OE2   1 
ATOM   3112 N N     . ALA A 1 396 ? -11.651 56.803  44.081  1.00 55.79 ? 689  ALA A N     1 
ATOM   3113 C CA    . ALA A 1 396 ? -11.593 57.872  43.093  1.00 52.95 ? 689  ALA A CA    1 
ATOM   3114 C C     . ALA A 1 396 ? -12.830 57.808  42.205  1.00 51.63 ? 689  ALA A C     1 
ATOM   3115 O O     . ALA A 1 396 ? -13.527 58.805  42.035  1.00 49.94 ? 689  ALA A O     1 
ATOM   3116 C CB    . ALA A 1 396 ? -10.327 57.775  42.278  1.00 55.11 ? 689  ALA A CB    1 
ATOM   3117 N N     . GLN A 1 397 ? -13.105 56.620  41.659  1.00 50.62 ? 690  GLN A N     1 
ATOM   3118 C CA    . GLN A 1 397 ? -14.253 56.417  40.792  1.00 52.29 ? 690  GLN A CA    1 
ATOM   3119 C C     . GLN A 1 397 ? -15.539 56.838  41.502  1.00 50.19 ? 690  GLN A C     1 
ATOM   3120 O O     . GLN A 1 397 ? -16.410 57.436  40.881  1.00 50.20 ? 690  GLN A O     1 
ATOM   3121 C CB    . GLN A 1 397 ? -14.365 54.951  40.374  1.00 56.16 ? 690  GLN A CB    1 
ATOM   3122 C CG    . GLN A 1 397 ? -13.254 54.485  39.446  1.00 60.04 ? 690  GLN A CG    1 
ATOM   3123 C CD    . GLN A 1 397 ? -13.346 53.000  39.189  1.00 59.36 ? 690  GLN A CD    1 
ATOM   3124 O OE1   . GLN A 1 397 ? -13.169 52.177  40.088  1.00 61.56 ? 690  GLN A OE1   1 
ATOM   3125 N NE2   . GLN A 1 397 ? -13.640 52.646  37.951  1.00 55.06 ? 690  GLN A NE2   1 
ATOM   3126 N N     . ALA A 1 398 ? -15.658 56.488  42.791  1.00 48.75 ? 691  ALA A N     1 
ATOM   3127 C CA    . ALA A 1 398 ? -16.825 56.830  43.591  1.00 47.62 ? 691  ALA A CA    1 
ATOM   3128 C C     . ALA A 1 398 ? -16.977 58.348  43.684  1.00 44.02 ? 691  ALA A C     1 
ATOM   3129 O O     . ALA A 1 398 ? -18.070 58.878  43.515  1.00 42.90 ? 691  ALA A O     1 
ATOM   3130 C CB    . ALA A 1 398 ? -16.702 56.218  44.969  1.00 47.22 ? 691  ALA A CB    1 
ATOM   3131 N N     . PHE A 1 399 ? -15.872 59.032  43.994  1.00 43.86 ? 692  PHE A N     1 
ATOM   3132 C CA    . PHE A 1 399 ? -15.840 60.485  44.038  1.00 47.72 ? 692  PHE A CA    1 
ATOM   3133 C C     . PHE A 1 399 ? -16.334 61.077  42.717  1.00 44.24 ? 692  PHE A C     1 
ATOM   3134 O O     . PHE A 1 399 ? -17.126 62.012  42.732  1.00 39.97 ? 692  PHE A O     1 
ATOM   3135 C CB    . PHE A 1 399 ? -14.430 60.985  44.366  1.00 51.00 ? 692  PHE A CB    1 
ATOM   3136 C CG    . PHE A 1 399 ? -14.037 60.915  45.822  1.00 58.25 ? 692  PHE A CG    1 
ATOM   3137 C CD1   . PHE A 1 399 ? -14.817 60.244  46.757  1.00 61.69 ? 692  PHE A CD1   1 
ATOM   3138 C CD2   . PHE A 1 399 ? -12.886 61.549  46.263  1.00 59.55 ? 692  PHE A CD2   1 
ATOM   3139 C CE1   . PHE A 1 399 ? -14.442 60.192  48.090  1.00 61.78 ? 692  PHE A CE1   1 
ATOM   3140 C CE2   . PHE A 1 399 ? -12.516 61.498  47.598  1.00 63.59 ? 692  PHE A CE2   1 
ATOM   3141 C CZ    . PHE A 1 399 ? -13.292 60.816  48.509  1.00 62.18 ? 692  PHE A CZ    1 
ATOM   3142 N N     . ILE A 1 400 ? -15.871 60.527  41.585  1.00 44.88 ? 693  ILE A N     1 
ATOM   3143 C CA    . ILE A 1 400 ? -16.238 61.053  40.275  1.00 46.31 ? 693  ILE A CA    1 
ATOM   3144 C C     . ILE A 1 400 ? -17.734 60.856  40.051  1.00 46.08 ? 693  ILE A C     1 
ATOM   3145 O O     . ILE A 1 400 ? -18.433 61.781  39.639  1.00 44.25 ? 693  ILE A O     1 
ATOM   3146 C CB    . ILE A 1 400 ? -15.380 60.419  39.163  1.00 47.88 ? 693  ILE A CB    1 
ATOM   3147 C CG1   . ILE A 1 400 ? -13.955 60.976  39.214  1.00 46.21 ? 693  ILE A CG1   1 
ATOM   3148 C CG2   . ILE A 1 400 ? -16.028 60.608  37.792  1.00 46.23 ? 693  ILE A CG2   1 
ATOM   3149 C CD1   . ILE A 1 400 ? -12.955 60.212  38.377  1.00 47.96 ? 693  ILE A CD1   1 
ATOM   3150 N N     . GLU A 1 401 ? -18.237 59.667  40.385  1.00 46.53 ? 694  GLU A N     1 
ATOM   3151 C CA    . GLU A 1 401 ? -19.657 59.405  40.231  1.00 48.69 ? 694  GLU A CA    1 
ATOM   3152 C C     . GLU A 1 401 ? -20.462 60.399  41.072  1.00 46.02 ? 694  GLU A C     1 
ATOM   3153 O O     . GLU A 1 401 ? -21.487 60.914  40.633  1.00 45.55 ? 694  GLU A O     1 
ATOM   3154 C CB    . GLU A 1 401 ? -19.963 57.946  40.576  1.00 52.98 ? 694  GLU A CB    1 
ATOM   3155 C CG    . GLU A 1 401 ? -21.040 57.361  39.689  1.00 59.99 ? 694  GLU A CG    1 
ATOM   3156 C CD    . GLU A 1 401 ? -20.839 57.727  38.227  1.00 64.49 ? 694  GLU A CD    1 
ATOM   3157 O OE1   . GLU A 1 401 ? -21.710 58.437  37.673  1.00 69.17 ? 694  GLU A OE1   1 
ATOM   3158 O OE2   . GLU A 1 401 ? -19.784 57.352  37.664  1.00 62.79 ? 694  GLU A OE2   1 
ATOM   3159 N N     . ARG A 1 402 ? -19.979 60.683  42.284  1.00 47.78 ? 695  ARG A N     1 
ATOM   3160 C CA    . ARG A 1 402 ? -20.659 61.604  43.182  1.00 45.91 ? 695  ARG A CA    1 
ATOM   3161 C C     . ARG A 1 402 ? -20.614 63.015  42.598  1.00 40.50 ? 695  ARG A C     1 
ATOM   3162 O O     . ARG A 1 402 ? -21.602 63.730  42.632  1.00 39.21 ? 695  ARG A O     1 
ATOM   3163 C CB    . ARG A 1 402 ? -20.039 61.528  44.579  1.00 48.37 ? 695  ARG A CB    1 
ATOM   3164 C CG    . ARG A 1 402 ? -20.999 61.923  45.688  1.00 51.63 ? 695  ARG A CG    1 
ATOM   3165 C CD    . ARG A 1 402 ? -20.464 61.555  47.055  1.00 53.66 ? 695  ARG A CD    1 
ATOM   3166 N NE    . ARG A 1 402 ? -21.186 62.256  48.110  1.00 58.29 ? 695  ARG A NE    1 
ATOM   3167 C CZ    . ARG A 1 402 ? -22.406 61.946  48.544  1.00 59.54 ? 695  ARG A CZ    1 
ATOM   3168 N NH1   . ARG A 1 402 ? -22.962 60.796  48.206  1.00 56.52 ? 695  ARG A NH1   1 
ATOM   3169 N NH2   . ARG A 1 402 ? -23.050 62.781  49.345  1.00 57.27 ? 695  ARG A NH2   1 
ATOM   3170 N N     . TYR A 1 403 ? -19.485 63.398  42.007  1.00 41.40 ? 696  TYR A N     1 
ATOM   3171 C CA    . TYR A 1 403 ? -19.383 64.698  41.361  1.00 44.06 ? 696  TYR A CA    1 
ATOM   3172 C C     . TYR A 1 403 ? -20.448 64.846  40.269  1.00 42.14 ? 696  TYR A C     1 
ATOM   3173 O O     . TYR A 1 403 ? -21.163 65.849  40.230  1.00 35.67 ? 696  TYR A O     1 
ATOM   3174 C CB    . TYR A 1 403 ? -17.971 64.918  40.810  1.00 42.12 ? 696  TYR A CB    1 
ATOM   3175 C CG    . TYR A 1 403 ? -17.805 66.211  40.053  1.00 43.48 ? 696  TYR A CG    1 
ATOM   3176 C CD1   . TYR A 1 403 ? -18.181 66.315  38.723  1.00 41.80 ? 696  TYR A CD1   1 
ATOM   3177 C CD2   . TYR A 1 403 ? -17.304 67.344  40.675  1.00 43.32 ? 696  TYR A CD2   1 
ATOM   3178 C CE1   . TYR A 1 403 ? -18.042 67.502  38.023  1.00 43.19 ? 696  TYR A CE1   1 
ATOM   3179 C CE2   . TYR A 1 403 ? -17.152 68.538  39.987  1.00 44.04 ? 696  TYR A CE2   1 
ATOM   3180 C CZ    . TYR A 1 403 ? -17.522 68.620  38.655  1.00 44.81 ? 696  TYR A CZ    1 
ATOM   3181 O OH    . TYR A 1 403 ? -17.390 69.804  37.969  1.00 45.49 ? 696  TYR A OH    1 
ATOM   3182 N N     . PHE A 1 404 ? -20.557 63.849  39.381  1.00 41.68 ? 697  PHE A N     1 
ATOM   3183 C CA    . PHE A 1 404 ? -21.433 63.979  38.225  1.00 42.16 ? 697  PHE A CA    1 
ATOM   3184 C C     . PHE A 1 404 ? -22.899 63.863  38.621  1.00 43.84 ? 697  PHE A C     1 
ATOM   3185 O O     . PHE A 1 404 ? -23.761 64.343  37.894  1.00 44.44 ? 697  PHE A O     1 
ATOM   3186 C CB    . PHE A 1 404 ? -21.058 62.987  37.125  1.00 43.94 ? 697  PHE A CB    1 
ATOM   3187 C CG    . PHE A 1 404 ? -19.804 63.375  36.387  1.00 42.05 ? 697  PHE A CG    1 
ATOM   3188 C CD1   . PHE A 1 404 ? -19.668 64.645  35.846  1.00 40.97 ? 697  PHE A CD1   1 
ATOM   3189 C CD2   . PHE A 1 404 ? -18.748 62.484  36.255  1.00 43.34 ? 697  PHE A CD2   1 
ATOM   3190 C CE1   . PHE A 1 404 ? -18.506 65.007  35.178  1.00 40.75 ? 697  PHE A CE1   1 
ATOM   3191 C CE2   . PHE A 1 404 ? -17.594 62.845  35.577  1.00 41.56 ? 697  PHE A CE2   1 
ATOM   3192 C CZ    . PHE A 1 404 ? -17.474 64.109  35.044  1.00 41.56 ? 697  PHE A CZ    1 
ATOM   3193 N N     . GLN A 1 405 ? -23.175 63.263  39.785  1.00 44.42 ? 698  GLN A N     1 
ATOM   3194 C CA    . GLN A 1 405 ? -24.509 63.294  40.360  1.00 44.72 ? 698  GLN A CA    1 
ATOM   3195 C C     . GLN A 1 405 ? -24.949 64.737  40.634  1.00 39.99 ? 698  GLN A C     1 
ATOM   3196 O O     . GLN A 1 405 ? -26.108 65.079  40.437  1.00 42.09 ? 698  GLN A O     1 
ATOM   3197 C CB    . GLN A 1 405 ? -24.522 62.450  41.633  1.00 49.74 ? 698  GLN A CB    1 
ATOM   3198 C CG    . GLN A 1 405 ? -25.914 62.061  42.104  1.00 54.48 ? 698  GLN A CG    1 
ATOM   3199 C CD    . GLN A 1 405 ? -25.858 61.430  43.475  1.00 59.60 ? 698  GLN A CD    1 
ATOM   3200 O OE1   . GLN A 1 405 ? -26.621 61.787  44.367  1.00 58.54 ? 698  GLN A OE1   1 
ATOM   3201 N NE2   . GLN A 1 405 ? -24.938 60.491  43.653  1.00 61.79 ? 698  GLN A NE2   1 
ATOM   3202 N N     . SER A 1 406 ? -24.033 65.590  41.098  1.00 38.44 ? 699  SER A N     1 
ATOM   3203 C CA    . SER A 1 406 ? -24.364 66.980  41.389  1.00 36.61 ? 699  SER A CA    1 
ATOM   3204 C C     . SER A 1 406 ? -24.214 67.893  40.166  1.00 34.66 ? 699  SER A C     1 
ATOM   3205 O O     . SER A 1 406 ? -24.902 68.904  40.076  1.00 33.09 ? 699  SER A O     1 
ATOM   3206 C CB    . SER A 1 406 ? -23.573 67.479  42.577  1.00 38.98 ? 699  SER A CB    1 
ATOM   3207 O OG    . SER A 1 406 ? -24.237 67.126  43.791  1.00 42.07 ? 699  SER A OG    1 
ATOM   3208 N N     . PHE A 1 407 ? -23.347 67.539  39.209  1.00 33.62 ? 700  PHE A N     1 
ATOM   3209 C CA    . PHE A 1 407 ? -23.171 68.336  38.002  1.00 35.01 ? 700  PHE A CA    1 
ATOM   3210 C C     . PHE A 1 407 ? -23.291 67.446  36.764  1.00 34.76 ? 700  PHE A C     1 
ATOM   3211 O O     . PHE A 1 407 ? -22.327 67.294  36.009  1.00 33.04 ? 700  PHE A O     1 
ATOM   3212 C CB    . PHE A 1 407 ? -21.809 69.037  38.008  1.00 36.68 ? 700  PHE A CB    1 
ATOM   3213 C CG    . PHE A 1 407 ? -21.495 69.803  39.264  1.00 39.04 ? 700  PHE A CG    1 
ATOM   3214 C CD1   . PHE A 1 407 ? -22.104 71.022  39.526  1.00 39.41 ? 700  PHE A CD1   1 
ATOM   3215 C CD2   . PHE A 1 407 ? -20.608 69.290  40.201  1.00 41.64 ? 700  PHE A CD2   1 
ATOM   3216 C CE1   . PHE A 1 407 ? -21.816 71.724  40.686  1.00 41.02 ? 700  PHE A CE1   1 
ATOM   3217 C CE2   . PHE A 1 407 ? -20.327 69.991  41.365  1.00 44.30 ? 700  PHE A CE2   1 
ATOM   3218 C CZ    . PHE A 1 407 ? -20.928 71.211  41.602  1.00 42.17 ? 700  PHE A CZ    1 
ATOM   3219 N N     . PRO A 1 408 ? -24.481 66.858  36.494  1.00 30.82 ? 701  PRO A N     1 
ATOM   3220 C CA    . PRO A 1 408 ? -24.649 65.940  35.360  1.00 31.19 ? 701  PRO A CA    1 
ATOM   3221 C C     . PRO A 1 408 ? -24.459 66.539  33.961  1.00 31.11 ? 701  PRO A C     1 
ATOM   3222 O O     . PRO A 1 408 ? -24.004 65.846  33.050  1.00 30.33 ? 701  PRO A O     1 
ATOM   3223 C CB    . PRO A 1 408 ? -26.093 65.428  35.541  1.00 32.49 ? 701  PRO A CB    1 
ATOM   3224 C CG    . PRO A 1 408 ? -26.797 66.506  36.350  1.00 32.54 ? 701  PRO A CG    1 
ATOM   3225 C CD    . PRO A 1 408 ? -25.722 67.055  37.260  1.00 31.40 ? 701  PRO A CD    1 
ATOM   3226 N N     . LYS A 1 409 ? -24.780 67.830  33.776  1.00 29.28 ? 702  LYS A N     1 
ATOM   3227 C CA    . LYS A 1 409 ? -24.564 68.463  32.479  1.00 32.22 ? 702  LYS A CA    1 
ATOM   3228 C C     . LYS A 1 409 ? -23.085 68.752  32.199  1.00 30.28 ? 702  LYS A C     1 
ATOM   3229 O O     . LYS A 1 409 ? -22.723 69.088  31.071  1.00 30.13 ? 702  LYS A O     1 
ATOM   3230 C CB    . LYS A 1 409 ? -25.378 69.753  32.344  1.00 32.15 ? 702  LYS A CB    1 
ATOM   3231 C CG    . LYS A 1 409 ? -26.853 69.511  32.052  1.00 37.57 ? 702  LYS A CG    1 
ATOM   3232 C CD    . LYS A 1 409 ? -27.566 70.758  31.596  1.00 38.84 ? 702  LYS A CD    1 
ATOM   3233 C CE    . LYS A 1 409 ? -29.049 70.541  31.416  1.00 41.45 ? 702  LYS A CE    1 
ATOM   3234 N NZ    . LYS A 1 409 ? -29.712 71.826  31.088  1.00 43.31 ? 702  LYS A NZ    1 
ATOM   3235 N N     . VAL A 1 410 ? -22.224 68.643  33.208  1.00 31.88 ? 703  VAL A N     1 
ATOM   3236 C CA    . VAL A 1 410 ? -20.799 68.723  32.942  1.00 32.42 ? 703  VAL A CA    1 
ATOM   3237 C C     . VAL A 1 410 ? -20.354 67.427  32.259  1.00 31.79 ? 703  VAL A C     1 
ATOM   3238 O O     . VAL A 1 410 ? -19.578 67.463  31.307  1.00 31.66 ? 703  VAL A O     1 
ATOM   3239 C CB    . VAL A 1 410 ? -20.002 69.046  34.216  1.00 32.92 ? 703  VAL A CB    1 
ATOM   3240 C CG1   . VAL A 1 410 ? -18.501 68.978  33.967  1.00 32.49 ? 703  VAL A CG1   1 
ATOM   3241 C CG2   . VAL A 1 410 ? -20.387 70.416  34.774  1.00 32.03 ? 703  VAL A CG2   1 
ATOM   3242 N N     . ARG A 1 411 ? -20.877 66.286  32.721  1.00 33.17 ? 704  ARG A N     1 
ATOM   3243 C CA    . ARG A 1 411 ? -20.626 65.004  32.076  1.00 34.95 ? 704  ARG A CA    1 
ATOM   3244 C C     . ARG A 1 411 ? -21.145 65.057  30.644  1.00 31.35 ? 704  ARG A C     1 
ATOM   3245 O O     . ARG A 1 411 ? -20.466 64.630  29.714  1.00 30.82 ? 704  ARG A O     1 
ATOM   3246 C CB    . ARG A 1 411 ? -21.287 63.853  32.845  1.00 39.79 ? 704  ARG A CB    1 
ATOM   3247 C CG    . ARG A 1 411 ? -21.267 62.521  32.106  1.00 43.90 ? 704  ARG A CG    1 
ATOM   3248 C CD    . ARG A 1 411 ? -21.857 61.371  32.901  1.00 48.22 ? 704  ARG A CD    1 
ATOM   3249 N NE    . ARG A 1 411 ? -20.836 60.559  33.552  1.00 51.88 ? 704  ARG A NE    1 
ATOM   3250 C CZ    . ARG A 1 411 ? -20.942 60.025  34.767  1.00 54.42 ? 704  ARG A CZ    1 
ATOM   3251 N NH1   . ARG A 1 411 ? -22.026 60.220  35.499  1.00 55.23 ? 704  ARG A NH1   1 
ATOM   3252 N NH2   . ARG A 1 411 ? -19.953 59.292  35.246  1.00 57.76 ? 704  ARG A NH2   1 
ATOM   3253 N N     . ALA A 1 412 ? -22.361 65.589  30.480  1.00 30.87 ? 705  ALA A N     1 
ATOM   3254 C CA    . ALA A 1 412 ? -22.962 65.726  29.163  1.00 31.67 ? 705  ALA A CA    1 
ATOM   3255 C C     . ALA A 1 412 ? -22.060 66.558  28.245  1.00 30.24 ? 705  ALA A C     1 
ATOM   3256 O O     . ALA A 1 412 ? -21.839 66.196  27.093  1.00 30.38 ? 705  ALA A O     1 
ATOM   3257 C CB    . ALA A 1 412 ? -24.347 66.316  29.290  1.00 32.92 ? 705  ALA A CB    1 
ATOM   3258 N N     . TRP A 1 413 ? -21.521 67.663  28.768  1.00 28.42 ? 706  TRP A N     1 
ATOM   3259 C CA    . TRP A 1 413 ? -20.666 68.538  27.991  1.00 27.87 ? 706  TRP A CA    1 
ATOM   3260 C C     . TRP A 1 413 ? -19.395 67.799  27.563  1.00 29.20 ? 706  TRP A C     1 
ATOM   3261 O O     . TRP A 1 413 ? -18.948 67.923  26.413  1.00 27.97 ? 706  TRP A O     1 
ATOM   3262 C CB    . TRP A 1 413 ? -20.360 69.803  28.789  1.00 28.10 ? 706  TRP A CB    1 
ATOM   3263 C CG    . TRP A 1 413 ? -19.416 70.709  28.064  1.00 30.18 ? 706  TRP A CG    1 
ATOM   3264 C CD1   . TRP A 1 413 ? -19.718 71.620  27.089  1.00 30.91 ? 706  TRP A CD1   1 
ATOM   3265 C CD2   . TRP A 1 413 ? -17.989 70.735  28.215  1.00 27.62 ? 706  TRP A CD2   1 
ATOM   3266 N NE1   . TRP A 1 413 ? -18.573 72.231  26.649  1.00 32.08 ? 706  TRP A NE1   1 
ATOM   3267 C CE2   . TRP A 1 413 ? -17.499 71.705  27.315  1.00 31.76 ? 706  TRP A CE2   1 
ATOM   3268 C CE3   . TRP A 1 413 ? -17.080 70.027  29.007  1.00 32.77 ? 706  TRP A CE3   1 
ATOM   3269 C CZ2   . TRP A 1 413 ? -16.134 71.984  27.198  1.00 34.11 ? 706  TRP A CZ2   1 
ATOM   3270 C CZ3   . TRP A 1 413 ? -15.732 70.305  28.895  1.00 33.04 ? 706  TRP A CZ3   1 
ATOM   3271 C CH2   . TRP A 1 413 ? -15.269 71.272  28.003  1.00 31.35 ? 706  TRP A CH2   1 
ATOM   3272 N N     . ILE A 1 414 ? -18.829 67.014  28.488  1.00 30.46 ? 707  ILE A N     1 
ATOM   3273 C CA    . ILE A 1 414 ? -17.636 66.225  28.207  1.00 33.22 ? 707  ILE A CA    1 
ATOM   3274 C C     . ILE A 1 414 ? -17.895 65.286  27.029  1.00 35.30 ? 707  ILE A C     1 
ATOM   3275 O O     . ILE A 1 414 ? -17.154 65.301  26.040  1.00 35.28 ? 707  ILE A O     1 
ATOM   3276 C CB    . ILE A 1 414 ? -17.159 65.484  29.477  1.00 35.34 ? 707  ILE A CB    1 
ATOM   3277 C CG1   . ILE A 1 414 ? -16.536 66.453  30.487  1.00 37.78 ? 707  ILE A CG1   1 
ATOM   3278 C CG2   . ILE A 1 414 ? -16.204 64.347  29.135  1.00 36.02 ? 707  ILE A CG2   1 
ATOM   3279 C CD1   . ILE A 1 414 ? -16.244 65.833  31.847  1.00 40.82 ? 707  ILE A CD1   1 
ATOM   3280 N N     . GLU A 1 415 ? -18.978 64.507  27.120  1.00 35.26 ? 708  GLU A N     1 
ATOM   3281 C CA    . GLU A 1 415 ? -19.319 63.527  26.100  1.00 35.33 ? 708  GLU A CA    1 
ATOM   3282 C C     . GLU A 1 415 ? -19.612 64.216  24.766  1.00 35.48 ? 708  GLU A C     1 
ATOM   3283 O O     . GLU A 1 415 ? -19.185 63.736  23.711  1.00 31.64 ? 708  GLU A O     1 
ATOM   3284 C CB    . GLU A 1 415 ? -20.479 62.658  26.599  1.00 38.75 ? 708  GLU A CB    1 
ATOM   3285 C CG    . GLU A 1 415 ? -20.075 61.753  27.756  1.00 41.48 ? 708  GLU A CG    1 
ATOM   3286 C CD    . GLU A 1 415 ? -21.200 61.079  28.531  1.00 49.70 ? 708  GLU A CD    1 
ATOM   3287 O OE1   . GLU A 1 415 ? -20.901 60.117  29.284  1.00 54.38 ? 708  GLU A OE1   1 
ATOM   3288 O OE2   . GLU A 1 415 ? -22.365 61.531  28.421  1.00 49.11 ? 708  GLU A OE2   1 
ATOM   3289 N N     . LYS A 1 416 ? -20.329 65.350  24.808  1.00 33.02 ? 709  LYS A N     1 
ATOM   3290 C CA    . LYS A 1 416 ? -20.697 66.042  23.587  1.00 34.15 ? 709  LYS A CA    1 
ATOM   3291 C C     . LYS A 1 416 ? -19.458 66.632  22.915  1.00 33.77 ? 709  LYS A C     1 
ATOM   3292 O O     . LYS A 1 416 ? -19.305 66.524  21.695  1.00 30.91 ? 709  LYS A O     1 
ATOM   3293 C CB    . LYS A 1 416 ? -21.746 67.118  23.864  1.00 36.68 ? 709  LYS A CB    1 
ATOM   3294 C CG    . LYS A 1 416 ? -22.100 67.958  22.645  1.00 41.74 ? 709  LYS A CG    1 
ATOM   3295 C CD    . LYS A 1 416 ? -23.342 68.793  22.810  1.00 44.56 ? 709  LYS A CD    1 
ATOM   3296 C CE    . LYS A 1 416 ? -23.625 69.640  21.585  1.00 47.17 ? 709  LYS A CE    1 
ATOM   3297 N NZ    . LYS A 1 416 ? -24.794 70.532  21.773  1.00 48.49 ? 709  LYS A NZ    1 
ATOM   3298 N N     . THR A 1 417 ? -18.583 67.275  23.706  1.00 31.57 ? 710  THR A N     1 
ATOM   3299 C CA    . THR A 1 417 ? -17.358 67.843  23.164  1.00 30.86 ? 710  THR A CA    1 
ATOM   3300 C C     . THR A 1 417 ? -16.566 66.777  22.398  1.00 31.32 ? 710  THR A C     1 
ATOM   3301 O O     . THR A 1 417 ? -16.090 67.027  21.291  1.00 29.65 ? 710  THR A O     1 
ATOM   3302 C CB    . THR A 1 417 ? -16.513 68.482  24.273  1.00 32.47 ? 710  THR A CB    1 
ATOM   3303 O OG1   . THR A 1 417 ? -17.300 69.459  24.946  1.00 31.78 ? 710  THR A OG1   1 
ATOM   3304 C CG2   . THR A 1 417 ? -15.261 69.151  23.755  1.00 34.92 ? 710  THR A CG2   1 
ATOM   3305 N N     . LEU A 1 418 ? -16.426 65.578  22.972  1.00 31.84 ? 711  LEU A N     1 
ATOM   3306 C CA    . LEU A 1 418 ? -15.645 64.532  22.323  1.00 34.39 ? 711  LEU A CA    1 
ATOM   3307 C C     . LEU A 1 418 ? -16.365 63.996  21.084  1.00 36.63 ? 711  LEU A C     1 
ATOM   3308 O O     . LEU A 1 418 ? -15.730 63.767  20.050  1.00 35.99 ? 711  LEU A O     1 
ATOM   3309 C CB    . LEU A 1 418 ? -15.359 63.394  23.309  1.00 34.56 ? 711  LEU A CB    1 
ATOM   3310 C CG    . LEU A 1 418 ? -14.274 63.630  24.359  1.00 36.93 ? 711  LEU A CG    1 
ATOM   3311 C CD1   . LEU A 1 418 ? -13.879 62.303  25.009  1.00 37.71 ? 711  LEU A CD1   1 
ATOM   3312 C CD2   . LEU A 1 418 ? -13.039 64.330  23.776  1.00 34.06 ? 711  LEU A CD2   1 
ATOM   3313 N N     . GLU A 1 419 ? -17.688 63.793  21.188  1.00 37.31 ? 712  GLU A N     1 
ATOM   3314 C CA    . GLU A 1 419 ? -18.471 63.298  20.063  1.00 37.83 ? 712  GLU A CA    1 
ATOM   3315 C C     . GLU A 1 419 ? -18.327 64.239  18.869  1.00 36.89 ? 712  GLU A C     1 
ATOM   3316 O O     . GLU A 1 419 ? -18.018 63.803  17.767  1.00 34.52 ? 712  GLU A O     1 
ATOM   3317 C CB    . GLU A 1 419 ? -19.948 63.134  20.428  1.00 38.80 ? 712  GLU A CB    1 
ATOM   3318 C CG    . GLU A 1 419 ? -20.757 62.390  19.375  1.00 39.53 ? 712  GLU A CG    1 
ATOM   3319 C CD    . GLU A 1 419 ? -21.184 63.196  18.157  1.00 42.98 ? 712  GLU A CD    1 
ATOM   3320 O OE1   . GLU A 1 419 ? -21.616 64.355  18.333  1.00 45.54 ? 712  GLU A OE1   1 
ATOM   3321 O OE2   . GLU A 1 419 ? -21.136 62.647  17.030  1.00 44.67 ? 712  GLU A OE2   1 
ATOM   3322 N N     . GLU A 1 420 ? -18.558 65.535  19.085  1.00 39.06 ? 713  GLU A N     1 
ATOM   3323 C CA    . GLU A 1 420 ? -18.451 66.485  17.994  1.00 39.16 ? 713  GLU A CA    1 
ATOM   3324 C C     . GLU A 1 420 ? -17.012 66.523  17.480  1.00 38.64 ? 713  GLU A C     1 
ATOM   3325 O O     . GLU A 1 420 ? -16.780 66.533  16.274  1.00 37.77 ? 713  GLU A O     1 
ATOM   3326 C CB    . GLU A 1 420 ? -18.921 67.872  18.418  1.00 40.15 ? 713  GLU A CB    1 
ATOM   3327 C CG    . GLU A 1 420 ? -20.400 67.945  18.716  1.00 43.03 ? 713  GLU A CG    1 
ATOM   3328 C CD    . GLU A 1 420 ? -20.905 69.369  18.850  1.00 46.28 ? 713  GLU A CD    1 
ATOM   3329 O OE1   . GLU A 1 420 ? -20.067 70.289  18.963  1.00 56.10 ? 713  GLU A OE1   1 
ATOM   3330 O OE2   . GLU A 1 420 ? -22.122 69.562  18.814  1.00 50.26 ? 713  GLU A OE2   1 
ATOM   3331 N N     . GLY A 1 421 ? -16.049 66.572  18.396  1.00 37.87 ? 714  GLY A N     1 
ATOM   3332 C CA    . GLY A 1 421 ? -14.648 66.590  18.006  1.00 40.62 ? 714  GLY A CA    1 
ATOM   3333 C C     . GLY A 1 421 ? -14.303 65.431  17.066  1.00 39.71 ? 714  GLY A C     1 
ATOM   3334 O O     . GLY A 1 421 ? -13.601 65.621  16.071  1.00 36.69 ? 714  GLY A O     1 
ATOM   3335 N N     . ARG A 1 422 ? -14.814 64.239  17.397  1.00 40.18 ? 715  ARG A N     1 
ATOM   3336 C CA    . ARG A 1 422 ? -14.539 63.032  16.633  1.00 40.97 ? 715  ARG A CA    1 
ATOM   3337 C C     . ARG A 1 422 ? -15.178 63.131  15.258  1.00 39.46 ? 715  ARG A C     1 
ATOM   3338 O O     . ARG A 1 422 ? -14.551 62.767  14.273  1.00 39.83 ? 715  ARG A O     1 
ATOM   3339 C CB    . ARG A 1 422 ? -15.056 61.780  17.345  1.00 40.23 ? 715  ARG A CB    1 
ATOM   3340 C CG    . ARG A 1 422 ? -14.116 61.254  18.418  1.00 42.12 ? 715  ARG A CG    1 
ATOM   3341 C CD    . ARG A 1 422 ? -14.548 59.917  18.992  1.00 42.40 ? 715  ARG A CD    1 
ATOM   3342 N NE    . ARG A 1 422 ? -15.889 59.988  19.556  1.00 44.88 ? 715  ARG A NE    1 
ATOM   3343 C CZ    . ARG A 1 422 ? -16.176 59.999  20.857  1.00 45.98 ? 715  ARG A CZ    1 
ATOM   3344 N NH1   . ARG A 1 422 ? -15.210 59.969  21.760  1.00 44.00 ? 715  ARG A NH1   1 
ATOM   3345 N NH2   . ARG A 1 422 ? -17.438 60.051  21.250  1.00 46.38 ? 715  ARG A NH2   1 
ATOM   3346 N N     . ARG A 1 423 ? -16.427 63.602  15.220  1.00 40.90 ? 716  ARG A N     1 
ATOM   3347 C CA    . ARG A 1 423 ? -17.221 63.634  14.003  1.00 41.43 ? 716  ARG A CA    1 
ATOM   3348 C C     . ARG A 1 423 ? -16.805 64.805  13.114  1.00 40.05 ? 716  ARG A C     1 
ATOM   3349 O O     . ARG A 1 423 ? -16.659 64.627  11.911  1.00 37.73 ? 716  ARG A O     1 
ATOM   3350 C CB    . ARG A 1 423 ? -18.718 63.703  14.336  1.00 41.07 ? 716  ARG A CB    1 
ATOM   3351 C CG    . ARG A 1 423 ? -19.609 64.104  13.165  1.00 44.13 ? 716  ARG A CG    1 
ATOM   3352 C CD    . ARG A 1 423 ? -21.094 63.880  13.417  1.00 44.37 ? 716  ARG A CD    1 
ATOM   3353 N NE    . ARG A 1 423 ? -21.607 64.516  14.624  1.00 39.96 ? 716  ARG A NE    1 
ATOM   3354 C CZ    . ARG A 1 423 ? -21.810 65.821  14.772  1.00 41.20 ? 716  ARG A CZ    1 
ATOM   3355 N NH1   . ARG A 1 423 ? -21.787 66.627  13.725  1.00 37.96 ? 716  ARG A NH1   1 
ATOM   3356 N NH2   . ARG A 1 423 ? -22.055 66.318  15.976  1.00 42.23 ? 716  ARG A NH2   1 
ATOM   3357 N N     . ARG A 1 424 ? -16.651 66.007  13.684  1.00 37.72 ? 717  ARG A N     1 
ATOM   3358 C CA    . ARG A 1 424 ? -16.388 67.187  12.869  1.00 39.23 ? 717  ARG A CA    1 
ATOM   3359 C C     . ARG A 1 424 ? -14.887 67.379  12.609  1.00 38.29 ? 717  ARG A C     1 
ATOM   3360 O O     . ARG A 1 424 ? -14.517 67.979  11.595  1.00 39.99 ? 717  ARG A O     1 
ATOM   3361 C CB    . ARG A 1 424 ? -17.001 68.436  13.508  1.00 40.01 ? 717  ARG A CB    1 
ATOM   3362 C CG    . ARG A 1 424 ? -18.487 68.322  13.818  1.00 40.47 ? 717  ARG A CG    1 
ATOM   3363 C CD    . ARG A 1 424 ? -18.963 69.512  14.635  1.00 42.91 ? 717  ARG A CD    1 
ATOM   3364 N NE    . ARG A 1 424 ? -19.400 70.620  13.806  1.00 47.88 ? 717  ARG A NE    1 
ATOM   3365 C CZ    . ARG A 1 424 ? -19.461 71.891  14.198  1.00 49.04 ? 717  ARG A CZ    1 
ATOM   3366 N NH1   . ARG A 1 424 ? -19.874 72.816  13.350  1.00 52.70 ? 717  ARG A NH1   1 
ATOM   3367 N NH2   . ARG A 1 424 ? -19.095 72.236  15.420  1.00 47.99 ? 717  ARG A NH2   1 
ATOM   3368 N N     . GLY A 1 425 ? -14.024 66.906  13.518  1.00 35.11 ? 718  GLY A N     1 
ATOM   3369 C CA    . GLY A 1 425 ? -12.584 67.077  13.372  1.00 34.30 ? 718  GLY A CA    1 
ATOM   3370 C C     . GLY A 1 425 ? -12.033 68.309  14.104  1.00 34.73 ? 718  GLY A C     1 
ATOM   3371 O O     . GLY A 1 425 ? -10.819 68.500  14.176  1.00 34.22 ? 718  GLY A O     1 
ATOM   3372 N N     . TYR A 1 426 ? -12.919 69.154  14.641  1.00 32.48 ? 719  TYR A N     1 
ATOM   3373 C CA    . TYR A 1 426 ? -12.491 70.306  15.408  1.00 32.72 ? 719  TYR A CA    1 
ATOM   3374 C C     . TYR A 1 426 ? -13.431 70.555  16.582  1.00 32.13 ? 719  TYR A C     1 
ATOM   3375 O O     . TYR A 1 426 ? -14.509 69.970  16.657  1.00 30.54 ? 719  TYR A O     1 
ATOM   3376 C CB    . TYR A 1 426 ? -12.421 71.539  14.511  1.00 32.83 ? 719  TYR A CB    1 
ATOM   3377 C CG    . TYR A 1 426 ? -13.715 71.965  13.869  1.00 34.11 ? 719  TYR A CG    1 
ATOM   3378 C CD1   . TYR A 1 426 ? -14.591 72.843  14.493  1.00 34.28 ? 719  TYR A CD1   1 
ATOM   3379 C CD2   . TYR A 1 426 ? -14.036 71.535  12.592  1.00 36.74 ? 719  TYR A CD2   1 
ATOM   3380 C CE1   . TYR A 1 426 ? -15.763 73.257  13.874  1.00 35.76 ? 719  TYR A CE1   1 
ATOM   3381 C CE2   . TYR A 1 426 ? -15.206 71.931  11.962  1.00 37.46 ? 719  TYR A CE2   1 
ATOM   3382 C CZ    . TYR A 1 426 ? -16.073 72.797  12.602  1.00 39.07 ? 719  TYR A CZ    1 
ATOM   3383 O OH    . TYR A 1 426 ? -17.213 73.166  11.928  1.00 41.13 ? 719  TYR A OH    1 
ATOM   3384 N N     . VAL A 1 427 ? -12.979 71.439  17.477  1.00 29.68 ? 720  VAL A N     1 
ATOM   3385 C CA    . VAL A 1 427 ? -13.770 71.971  18.573  1.00 29.38 ? 720  VAL A CA    1 
ATOM   3386 C C     . VAL A 1 427 ? -13.728 73.492  18.450  1.00 28.08 ? 720  VAL A C     1 
ATOM   3387 O O     . VAL A 1 427 ? -12.903 74.027  17.717  1.00 28.65 ? 720  VAL A O     1 
ATOM   3388 C CB    . VAL A 1 427 ? -13.258 71.489  19.949  1.00 28.96 ? 720  VAL A CB    1 
ATOM   3389 C CG1   . VAL A 1 427 ? -13.460 69.997  20.139  1.00 29.68 ? 720  VAL A CG1   1 
ATOM   3390 C CG2   . VAL A 1 427 ? -11.799 71.849  20.199  1.00 29.51 ? 720  VAL A CG2   1 
ATOM   3391 N N     . GLU A 1 428 ? -14.596 74.180  19.189  1.00 27.30 ? 721  GLU A N     1 
ATOM   3392 C CA    . GLU A 1 428 ? -14.695 75.619  19.056  1.00 29.15 ? 721  GLU A CA    1 
ATOM   3393 C C     . GLU A 1 428 ? -15.034 76.242  20.404  1.00 29.79 ? 721  GLU A C     1 
ATOM   3394 O O     . GLU A 1 428 ? -15.484 75.562  21.335  1.00 26.50 ? 721  GLU A O     1 
ATOM   3395 C CB    . GLU A 1 428 ? -15.643 75.998  17.913  1.00 34.21 ? 721  GLU A CB    1 
ATOM   3396 C CG    . GLU A 1 428 ? -17.048 75.445  18.030  1.00 38.03 ? 721  GLU A CG    1 
ATOM   3397 C CD    . GLU A 1 428 ? -17.888 75.468  16.751  1.00 42.12 ? 721  GLU A CD    1 
ATOM   3398 O OE1   . GLU A 1 428 ? -17.470 76.108  15.749  1.00 39.33 ? 721  GLU A OE1   1 
ATOM   3399 O OE2   . GLU A 1 428 ? -18.958 74.808  16.750  1.00 40.86 ? 721  GLU A OE2   1 
ATOM   3400 N N     . THR A 1 429 ? -14.710 77.538  20.496  1.00 27.75 ? 722  THR A N     1 
ATOM   3401 C CA    . THR A 1 429 ? -15.097 78.378  21.610  1.00 26.72 ? 722  THR A CA    1 
ATOM   3402 C C     . THR A 1 429 ? -16.530 78.869  21.410  1.00 27.88 ? 722  THR A C     1 
ATOM   3403 O O     . THR A 1 429 ? -17.155 78.567  20.394  1.00 26.02 ? 722  THR A O     1 
ATOM   3404 C CB    . THR A 1 429 ? -14.126 79.556  21.756  1.00 26.04 ? 722  THR A CB    1 
ATOM   3405 O OG1   . THR A 1 429 ? -14.363 80.458  20.670  1.00 25.88 ? 722  THR A OG1   1 
ATOM   3406 C CG2   . THR A 1 429 ? -12.677 79.098  21.784  1.00 26.51 ? 722  THR A CG2   1 
ATOM   3407 N N     . LEU A 1 430 ? -17.000 79.645  22.400  1.00 28.97 ? 723  LEU A N     1 
ATOM   3408 C CA    . LEU A 1 430 ? -18.321 80.246  22.417  1.00 29.93 ? 723  LEU A CA    1 
ATOM   3409 C C     . LEU A 1 430 ? -18.523 81.098  21.176  1.00 30.99 ? 723  LEU A C     1 
ATOM   3410 O O     . LEU A 1 430 ? -19.584 81.027  20.574  1.00 30.03 ? 723  LEU A O     1 
ATOM   3411 C CB    . LEU A 1 430 ? -18.466 81.114  23.667  1.00 29.42 ? 723  LEU A CB    1 
ATOM   3412 C CG    . LEU A 1 430 ? -19.783 81.875  23.801  1.00 30.06 ? 723  LEU A CG    1 
ATOM   3413 C CD1   . LEU A 1 430 ? -20.965 80.926  23.835  1.00 29.62 ? 723  LEU A CD1   1 
ATOM   3414 C CD2   . LEU A 1 430 ? -19.765 82.736  25.046  1.00 32.36 ? 723  LEU A CD2   1 
ATOM   3415 N N     . PHE A 1 431 ? -17.486 81.874  20.806  1.00 31.55 ? 724  PHE A N     1 
ATOM   3416 C CA    . PHE A 1 431 ? -17.565 82.828  19.717  1.00 30.83 ? 724  PHE A CA    1 
ATOM   3417 C C     . PHE A 1 431 ? -17.257 82.172  18.368  1.00 31.13 ? 724  PHE A C     1 
ATOM   3418 O O     . PHE A 1 431 ? -17.339 82.847  17.348  1.00 33.58 ? 724  PHE A O     1 
ATOM   3419 C CB    . PHE A 1 431 ? -16.601 83.998  19.963  1.00 34.50 ? 724  PHE A CB    1 
ATOM   3420 C CG    . PHE A 1 431 ? -16.947 84.924  21.102  1.00 37.29 ? 724  PHE A CG    1 
ATOM   3421 C CD1   . PHE A 1 431 ? -18.124 84.786  21.827  1.00 40.67 ? 724  PHE A CD1   1 
ATOM   3422 C CD2   . PHE A 1 431 ? -16.079 85.944  21.460  1.00 42.55 ? 724  PHE A CD2   1 
ATOM   3423 C CE1   . PHE A 1 431 ? -18.420 85.640  22.876  1.00 40.74 ? 724  PHE A CE1   1 
ATOM   3424 C CE2   . PHE A 1 431 ? -16.379 86.801  22.511  1.00 44.16 ? 724  PHE A CE2   1 
ATOM   3425 C CZ    . PHE A 1 431 ? -17.545 86.640  23.226  1.00 40.38 ? 724  PHE A CZ    1 
ATOM   3426 N N     . GLY A 1 432 ? -16.902 80.880  18.340  1.00 27.67 ? 725  GLY A N     1 
ATOM   3427 C CA    . GLY A 1 432 ? -16.666 80.181  17.081  1.00 26.65 ? 725  GLY A CA    1 
ATOM   3428 C C     . GLY A 1 432 ? -15.191 80.114  16.638  1.00 27.61 ? 725  GLY A C     1 
ATOM   3429 O O     . GLY A 1 432 ? -14.891 79.723  15.507  1.00 28.97 ? 725  GLY A O     1 
ATOM   3430 N N     . ARG A 1 433 ? -14.252 80.496  17.501  1.00 25.54 ? 726  ARG A N     1 
ATOM   3431 C CA    . ARG A 1 433 ? -12.851 80.160  17.262  1.00 25.87 ? 726  ARG A CA    1 
ATOM   3432 C C     . ARG A 1 433 ? -12.696 78.639  17.247  1.00 26.09 ? 726  ARG A C     1 
ATOM   3433 O O     . ARG A 1 433 ? -13.293 77.926  18.060  1.00 26.19 ? 726  ARG A O     1 
ATOM   3434 C CB    . ARG A 1 433 ? -11.942 80.797  18.318  1.00 26.27 ? 726  ARG A CB    1 
ATOM   3435 C CG    . ARG A 1 433 ? -10.453 80.737  17.986  1.00 27.33 ? 726  ARG A CG    1 
ATOM   3436 C CD    . ARG A 1 433 ? -9.605  81.221  19.146  1.00 28.27 ? 726  ARG A CD    1 
ATOM   3437 N NE    . ARG A 1 433 ? -9.828  82.629  19.470  1.00 29.35 ? 726  ARG A NE    1 
ATOM   3438 C CZ    . ARG A 1 433 ? -9.307  83.651  18.808  1.00 31.19 ? 726  ARG A CZ    1 
ATOM   3439 N NH1   . ARG A 1 433 ? -8.430  83.448  17.836  1.00 29.58 ? 726  ARG A NH1   1 
ATOM   3440 N NH2   . ARG A 1 433 ? -9.681  84.880  19.117  1.00 33.23 ? 726  ARG A NH2   1 
ATOM   3441 N N     . ARG A 1 434 ? -11.895 78.153  16.296  1.00 27.07 ? 727  ARG A N     1 
ATOM   3442 C CA    . ARG A 1 434 ? -11.882 76.755  15.915  1.00 30.71 ? 727  ARG A CA    1 
ATOM   3443 C C     . ARG A 1 434 ? -10.482 76.177  16.119  1.00 29.85 ? 727  ARG A C     1 
ATOM   3444 O O     . ARG A 1 434 ? -9.481  76.836  15.816  1.00 27.73 ? 727  ARG A O     1 
ATOM   3445 C CB    . ARG A 1 434 ? -12.288 76.699  14.441  1.00 36.63 ? 727  ARG A CB    1 
ATOM   3446 C CG    . ARG A 1 434 ? -12.648 75.323  13.903  1.00 43.74 ? 727  ARG A CG    1 
ATOM   3447 C CD    . ARG A 1 434 ? -13.119 75.395  12.447  1.00 48.91 ? 727  ARG A CD    1 
ATOM   3448 N NE    . ARG A 1 434 ? -14.322 76.205  12.234  1.00 51.02 ? 727  ARG A NE    1 
ATOM   3449 C CZ    . ARG A 1 434 ? -14.552 77.018  11.196  1.00 51.29 ? 727  ARG A CZ    1 
ATOM   3450 N NH1   . ARG A 1 434 ? -13.627 77.251  10.281  1.00 48.27 ? 727  ARG A NH1   1 
ATOM   3451 N NH2   . ARG A 1 434 ? -15.736 77.592  11.065  1.00 49.87 ? 727  ARG A NH2   1 
ATOM   3452 N N     . ARG A 1 435 ? -10.416 74.952  16.645  1.00 29.30 ? 728  ARG A N     1 
ATOM   3453 C CA    . ARG A 1 435 ? -9.162  74.209  16.660  1.00 29.88 ? 728  ARG A CA    1 
ATOM   3454 C C     . ARG A 1 435 ? -9.396  72.774  16.208  1.00 27.81 ? 728  ARG A C     1 
ATOM   3455 O O     . ARG A 1 435 ? -10.215 72.070  16.780  1.00 27.37 ? 728  ARG A O     1 
ATOM   3456 C CB    . ARG A 1 435 ? -8.511  74.163  18.044  1.00 33.03 ? 728  ARG A CB    1 
ATOM   3457 C CG    . ARG A 1 435 ? -7.128  73.517  18.030  1.00 34.57 ? 728  ARG A CG    1 
ATOM   3458 C CD    . ARG A 1 435 ? -6.694  73.227  19.433  1.00 38.99 ? 728  ARG A CD    1 
ATOM   3459 N NE    . ARG A 1 435 ? -5.403  72.576  19.523  1.00 40.67 ? 728  ARG A NE    1 
ATOM   3460 C CZ    . ARG A 1 435 ? -4.845  72.230  20.674  1.00 40.92 ? 728  ARG A CZ    1 
ATOM   3461 N NH1   . ARG A 1 435 ? -5.442  72.534  21.816  1.00 49.58 ? 728  ARG A NH1   1 
ATOM   3462 N NH2   . ARG A 1 435 ? -3.694  71.586  20.675  1.00 47.81 ? 728  ARG A NH2   1 
ATOM   3463 N N     . TYR A 1 436 ? -8.589  72.349  15.233  1.00 28.66 ? 729  TYR A N     1 
ATOM   3464 C CA    . TYR A 1 436 ? -8.633  71.014  14.679  1.00 27.87 ? 729  TYR A CA    1 
ATOM   3465 C C     . TYR A 1 436 ? -7.792  70.137  15.598  1.00 31.56 ? 729  TYR A C     1 
ATOM   3466 O O     . TYR A 1 436 ? -6.683  70.524  15.967  1.00 33.06 ? 729  TYR A O     1 
ATOM   3467 C CB    . TYR A 1 436 ? -8.208  71.063  13.202  1.00 29.27 ? 729  TYR A CB    1 
ATOM   3468 C CG    . TYR A 1 436 ? -9.092  71.935  12.328  1.00 30.87 ? 729  TYR A CG    1 
ATOM   3469 C CD1   . TYR A 1 436 ? -8.884  73.305  12.215  1.00 32.08 ? 729  TYR A CD1   1 
ATOM   3470 C CD2   . TYR A 1 436 ? -10.163 71.390  11.628  1.00 29.23 ? 729  TYR A CD2   1 
ATOM   3471 C CE1   . TYR A 1 436 ? -9.711  74.102  11.429  1.00 34.82 ? 729  TYR A CE1   1 
ATOM   3472 C CE2   . TYR A 1 436 ? -11.008 72.170  10.858  1.00 30.77 ? 729  TYR A CE2   1 
ATOM   3473 C CZ    . TYR A 1 436 ? -10.787 73.535  10.758  1.00 33.18 ? 729  TYR A CZ    1 
ATOM   3474 O OH    . TYR A 1 436 ? -11.615 74.296  9.952   1.00 32.57 ? 729  TYR A OH    1 
ATOM   3475 N N     . VAL A 1 437 ? -8.385  69.025  16.053  1.00 30.99 ? 730  VAL A N     1 
ATOM   3476 C CA    . VAL A 1 437 ? -7.782  68.150  17.040  1.00 29.87 ? 730  VAL A CA    1 
ATOM   3477 C C     . VAL A 1 437 ? -7.759  66.732  16.475  1.00 32.41 ? 730  VAL A C     1 
ATOM   3478 O O     . VAL A 1 437 ? -8.751  66.013  16.560  1.00 30.11 ? 730  VAL A O     1 
ATOM   3479 C CB    . VAL A 1 437 ? -8.528  68.148  18.386  1.00 31.13 ? 730  VAL A CB    1 
ATOM   3480 C CG1   . VAL A 1 437 ? -7.818  67.214  19.359  1.00 33.14 ? 730  VAL A CG1   1 
ATOM   3481 C CG2   . VAL A 1 437 ? -8.679  69.543  18.973  1.00 32.34 ? 730  VAL A CG2   1 
ATOM   3482 N N     . PRO A 1 438 ? -6.627  66.279  15.900  1.00 34.31 ? 731  PRO A N     1 
ATOM   3483 C CA    . PRO A 1 438 ? -6.516  64.907  15.409  1.00 35.96 ? 731  PRO A CA    1 
ATOM   3484 C C     . PRO A 1 438 ? -6.406  63.884  16.539  1.00 36.04 ? 731  PRO A C     1 
ATOM   3485 O O     . PRO A 1 438 ? -6.347  64.237  17.716  1.00 33.67 ? 731  PRO A O     1 
ATOM   3486 C CB    . PRO A 1 438 ? -5.225  64.920  14.574  1.00 39.83 ? 731  PRO A CB    1 
ATOM   3487 C CG    . PRO A 1 438 ? -4.906  66.391  14.372  1.00 40.73 ? 731  PRO A CG    1 
ATOM   3488 C CD    . PRO A 1 438 ? -5.426  67.080  15.619  1.00 38.13 ? 731  PRO A CD    1 
ATOM   3489 N N     . ASP A 1 439 ? -6.445  62.605  16.148  1.00 37.30 ? 732  ASP A N     1 
ATOM   3490 C CA    . ASP A 1 439 ? -6.088  61.489  17.009  1.00 35.80 ? 732  ASP A CA    1 
ATOM   3491 C C     . ASP A 1 439 ? -7.122  61.242  18.101  1.00 34.22 ? 732  ASP A C     1 
ATOM   3492 O O     . ASP A 1 439 ? -6.837  60.513  19.057  1.00 34.29 ? 732  ASP A O     1 
ATOM   3493 C CB    . ASP A 1 439 ? -4.693  61.687  17.601  1.00 38.00 ? 732  ASP A CB    1 
ATOM   3494 C CG    . ASP A 1 439 ? -3.612  61.535  16.547  1.00 41.94 ? 732  ASP A CG    1 
ATOM   3495 O OD1   . ASP A 1 439 ? -3.910  60.950  15.496  1.00 43.77 ? 732  ASP A OD1   1 
ATOM   3496 O OD2   . ASP A 1 439 ? -2.509  62.031  16.771  1.00 43.45 ? 732  ASP A OD2   1 
ATOM   3497 N N     . LEU A 1 440 ? -8.321  61.807  17.952  1.00 30.99 ? 733  LEU A N     1 
ATOM   3498 C CA    . LEU A 1 440 ? -9.387  61.556  18.911  1.00 33.74 ? 733  LEU A CA    1 
ATOM   3499 C C     . LEU A 1 440 ? -9.897  60.117  18.811  1.00 38.10 ? 733  LEU A C     1 
ATOM   3500 O O     . LEU A 1 440 ? -10.538 59.632  19.751  1.00 40.14 ? 733  LEU A O     1 
ATOM   3501 C CB    . LEU A 1 440 ? -10.517 62.564  18.679  1.00 30.84 ? 733  LEU A CB    1 
ATOM   3502 C CG    . LEU A 1 440 ? -10.222 63.978  19.183  1.00 30.23 ? 733  LEU A CG    1 
ATOM   3503 C CD1   . LEU A 1 440 ? -11.379 64.911  18.892  1.00 30.25 ? 733  LEU A CD1   1 
ATOM   3504 C CD2   . LEU A 1 440 ? -9.899  63.983  20.668  1.00 29.64 ? 733  LEU A CD2   1 
ATOM   3505 N N     . GLU A 1 441 ? -9.630  59.452  17.675  1.00 38.58 ? 734  GLU A N     1 
ATOM   3506 C CA    . GLU A 1 441 ? -9.920  58.033  17.526  1.00 46.30 ? 734  GLU A CA    1 
ATOM   3507 C C     . GLU A 1 441 ? -8.646  57.220  17.280  1.00 47.35 ? 734  GLU A C     1 
ATOM   3508 O O     . GLU A 1 441 ? -8.705  56.151  16.682  1.00 53.39 ? 734  GLU A O     1 
ATOM   3509 C CB    . GLU A 1 441 ? -10.965 57.834  16.427  1.00 47.55 ? 734  GLU A CB    1 
ATOM   3510 C CG    . GLU A 1 441 ? -12.364 58.166  16.911  1.00 52.99 ? 734  GLU A CG    1 
ATOM   3511 C CD    . GLU A 1 441 ? -13.470 57.929  15.905  1.00 58.81 ? 734  GLU A CD    1 
ATOM   3512 O OE1   . GLU A 1 441 ? -13.462 58.611  14.867  1.00 58.80 ? 734  GLU A OE1   1 
ATOM   3513 O OE2   . GLU A 1 441 ? -14.334 57.063  16.169  1.00 68.05 ? 734  GLU A OE2   1 
ATOM   3514 N N     . ALA A 1 442 ? -7.510  57.678  17.814  1.00 46.71 ? 735  ALA A N     1 
ATOM   3515 C CA    . ALA A 1 442 ? -6.273  56.919  17.735  1.00 49.24 ? 735  ALA A CA    1 
ATOM   3516 C C     . ALA A 1 442 ? -6.421  55.582  18.469  1.00 54.90 ? 735  ALA A C     1 
ATOM   3517 O O     . ALA A 1 442 ? -7.114  55.487  19.487  1.00 50.05 ? 735  ALA A O     1 
ATOM   3518 C CB    . ALA A 1 442 ? -5.139  57.742  18.295  1.00 47.29 ? 735  ALA A CB    1 
ATOM   3519 N N     . ARG A 1 443 ? -5.746  54.551  17.934  1.00 62.54 ? 736  ARG A N     1 
ATOM   3520 C CA    . ARG A 1 443 ? -5.810  53.195  18.468  1.00 64.35 ? 736  ARG A CA    1 
ATOM   3521 C C     . ARG A 1 443 ? -5.062  53.098  19.793  1.00 57.43 ? 736  ARG A C     1 
ATOM   3522 O O     . ARG A 1 443 ? -5.493  52.373  20.682  1.00 57.51 ? 736  ARG A O     1 
ATOM   3523 C CB    . ARG A 1 443 ? -5.196  52.178  17.501  1.00 69.44 ? 736  ARG A CB    1 
ATOM   3524 C CG    . ARG A 1 443 ? -5.836  52.157  16.122  1.00 78.15 ? 736  ARG A CG    1 
ATOM   3525 C CD    . ARG A 1 443 ? -5.617  50.837  15.401  1.00 85.47 ? 736  ARG A CD    1 
ATOM   3526 N NE    . ARG A 1 443 ? -5.630  50.975  13.948  1.00 91.49 ? 736  ARG A NE    1 
ATOM   3527 C CZ    . ARG A 1 443 ? -6.591  51.566  13.243  1.00 94.21 ? 736  ARG A CZ    1 
ATOM   3528 N NH1   . ARG A 1 443 ? -7.667  52.044  13.842  1.00 94.00 ? 736  ARG A NH1   1 
ATOM   3529 N NH2   . ARG A 1 443 ? -6.470  51.678  11.930  1.00 93.68 ? 736  ARG A NH2   1 
ATOM   3530 N N     . VAL A 1 444 ? -3.928  53.804  19.898  1.00 55.55 ? 737  VAL A N     1 
ATOM   3531 C CA    . VAL A 1 444 ? -3.137  53.843  21.120  1.00 54.63 ? 737  VAL A CA    1 
ATOM   3532 C C     . VAL A 1 444 ? -3.821  54.756  22.147  1.00 57.79 ? 737  VAL A C     1 
ATOM   3533 O O     . VAL A 1 444 ? -3.901  55.974  21.957  1.00 50.28 ? 737  VAL A O     1 
ATOM   3534 C CB    . VAL A 1 444 ? -1.689  54.292  20.837  1.00 51.48 ? 737  VAL A CB    1 
ATOM   3535 C CG1   . VAL A 1 444 ? -0.848  54.269  22.105  1.00 51.62 ? 737  VAL A CG1   1 
ATOM   3536 C CG2   . VAL A 1 444 ? -1.035  53.453  19.744  1.00 50.18 ? 737  VAL A CG2   1 
ATOM   3537 N N     . LYS A 1 445 ? -4.272  54.138  23.250  1.00 54.28 ? 738  LYS A N     1 
ATOM   3538 C CA    . LYS A 1 445 ? -5.023  54.776  24.322  1.00 58.08 ? 738  LYS A CA    1 
ATOM   3539 C C     . LYS A 1 445 ? -4.343  56.064  24.787  1.00 54.08 ? 738  LYS A C     1 
ATOM   3540 O O     . LYS A 1 445 ? -5.000  57.084  24.957  1.00 50.95 ? 738  LYS A O     1 
ATOM   3541 C CB    . LYS A 1 445 ? -5.170  53.766  25.467  1.00 59.51 ? 738  LYS A CB    1 
ATOM   3542 C CG    . LYS A 1 445 ? -5.907  54.228  26.716  1.00 61.04 ? 738  LYS A CG    1 
ATOM   3543 C CD    . LYS A 1 445 ? -6.220  53.065  27.650  1.00 64.64 ? 738  LYS A CD    1 
ATOM   3544 C CE    . LYS A 1 445 ? -6.401  53.447  29.107  1.00 69.40 ? 738  LYS A CE    1 
ATOM   3545 N NZ    . LYS A 1 445 ? -7.700  54.115  29.366  1.00 71.35 ? 738  LYS A NZ    1 
ATOM   3546 N N     . SER A 1 446 ? -3.027  56.020  25.001  1.00 52.83 ? 739  SER A N     1 
ATOM   3547 C CA    . SER A 1 446 ? -2.303  57.182  25.500  1.00 51.30 ? 739  SER A CA    1 
ATOM   3548 C C     . SER A 1 446 ? -2.392  58.350  24.512  1.00 46.59 ? 739  SER A C     1 
ATOM   3549 O O     . SER A 1 446 ? -2.564  59.486  24.934  1.00 46.76 ? 739  SER A O     1 
ATOM   3550 C CB    . SER A 1 446 ? -0.866  56.841  25.815  1.00 50.81 ? 739  SER A CB    1 
ATOM   3551 O OG    . SER A 1 446 ? -0.106  56.701  24.621  1.00 51.84 ? 739  SER A OG    1 
ATOM   3552 N N     . VAL A 1 447 ? -2.267  58.066  23.207  1.00 42.57 ? 740  VAL A N     1 
ATOM   3553 C CA    . VAL A 1 447 ? -2.294  59.091  22.170  1.00 41.53 ? 740  VAL A CA    1 
ATOM   3554 C C     . VAL A 1 447 ? -3.704  59.686  22.080  1.00 40.63 ? 740  VAL A C     1 
ATOM   3555 O O     . VAL A 1 447 ? -3.866  60.889  21.879  1.00 35.54 ? 740  VAL A O     1 
ATOM   3556 C CB    . VAL A 1 447 ? -1.834  58.532  20.808  1.00 41.90 ? 740  VAL A CB    1 
ATOM   3557 C CG1   . VAL A 1 447 ? -1.923  59.575  19.704  1.00 42.95 ? 740  VAL A CG1   1 
ATOM   3558 C CG2   . VAL A 1 447 ? -0.425  57.946  20.867  1.00 43.74 ? 740  VAL A CG2   1 
ATOM   3559 N N     . ARG A 1 448 ? -4.706  58.815  22.234  1.00 37.92 ? 741  ARG A N     1 
ATOM   3560 C CA    . ARG A 1 448 ? -6.109  59.162  22.145  1.00 37.93 ? 741  ARG A CA    1 
ATOM   3561 C C     . ARG A 1 448 ? -6.498  60.080  23.300  1.00 37.20 ? 741  ARG A C     1 
ATOM   3562 O O     . ARG A 1 448 ? -7.129  61.109  23.088  1.00 32.47 ? 741  ARG A O     1 
ATOM   3563 C CB    . ARG A 1 448 ? -6.941  57.880  22.191  1.00 40.94 ? 741  ARG A CB    1 
ATOM   3564 C CG    . ARG A 1 448 ? -8.405  58.056  21.826  1.00 44.81 ? 741  ARG A CG    1 
ATOM   3565 C CD    . ARG A 1 448 ? -9.140  56.724  21.778  1.00 47.56 ? 741  ARG A CD    1 
ATOM   3566 N NE    . ARG A 1 448 ? -10.050 56.567  22.901  1.00 52.33 ? 741  ARG A NE    1 
ATOM   3567 C CZ    . ARG A 1 448 ? -9.694  56.289  24.148  1.00 55.15 ? 741  ARG A CZ    1 
ATOM   3568 N NH1   . ARG A 1 448 ? -8.903  55.261  24.400  1.00 55.76 ? 741  ARG A NH1   1 
ATOM   3569 N NH2   . ARG A 1 448 ? -10.202 56.999  25.141  1.00 52.92 ? 741  ARG A NH2   1 
ATOM   3570 N N     . GLN A 1 449 ? -6.137  59.672  24.516  1.00 34.60 ? 742  GLN A N     1 
ATOM   3571 C CA    . GLN A 1 449 ? -6.487  60.406  25.718  1.00 38.70 ? 742  GLN A CA    1 
ATOM   3572 C C     . GLN A 1 449 ? -5.756  61.748  25.749  1.00 39.02 ? 742  GLN A C     1 
ATOM   3573 O O     . GLN A 1 449 ? -6.324  62.748  26.189  1.00 37.10 ? 742  GLN A O     1 
ATOM   3574 C CB    . GLN A 1 449 ? -6.205  59.560  26.961  1.00 39.86 ? 742  GLN A CB    1 
ATOM   3575 C CG    . GLN A 1 449 ? -7.123  58.348  27.064  1.00 43.84 ? 742  GLN A CG    1 
ATOM   3576 C CD    . GLN A 1 449 ? -7.080  57.707  28.429  1.00 45.67 ? 742  GLN A CD    1 
ATOM   3577 O OE1   . GLN A 1 449 ? -6.027  57.606  29.054  1.00 44.44 ? 742  GLN A OE1   1 
ATOM   3578 N NE2   . GLN A 1 449 ? -8.240  57.292  28.910  1.00 46.29 ? 742  GLN A NE2   1 
ATOM   3579 N N     . ALA A 1 450 ? -4.511  61.775  25.261  1.00 34.32 ? 743  ALA A N     1 
ATOM   3580 C CA    . ALA A 1 450 ? -3.780  63.024  25.179  1.00 35.21 ? 743  ALA A CA    1 
ATOM   3581 C C     . ALA A 1 450 ? -4.535  63.995  24.271  1.00 34.34 ? 743  ALA A C     1 
ATOM   3582 O O     . ALA A 1 450 ? -4.661  65.173  24.610  1.00 33.68 ? 743  ALA A O     1 
ATOM   3583 C CB    . ALA A 1 450 ? -2.353  62.781  24.728  1.00 35.69 ? 743  ALA A CB    1 
ATOM   3584 N N     . ALA A 1 451 ? -5.097  63.487  23.161  1.00 31.72 ? 744  ALA A N     1 
ATOM   3585 C CA    . ALA A 1 451 ? -5.862  64.328  22.251  1.00 31.94 ? 744  ALA A CA    1 
ATOM   3586 C C     . ALA A 1 451 ? -7.177  64.781  22.888  1.00 30.87 ? 744  ALA A C     1 
ATOM   3587 O O     . ALA A 1 451 ? -7.618  65.908  22.656  1.00 30.57 ? 744  ALA A O     1 
ATOM   3588 C CB    . ALA A 1 451 ? -6.107  63.621  20.945  1.00 32.95 ? 744  ALA A CB    1 
ATOM   3589 N N     . GLU A 1 452 ? -7.818  63.900  23.667  1.00 29.90 ? 745  GLU A N     1 
ATOM   3590 C CA    . GLU A 1 452 ? -9.082  64.239  24.310  1.00 32.01 ? 745  GLU A CA    1 
ATOM   3591 C C     . GLU A 1 452 ? -8.877  65.449  25.224  1.00 31.40 ? 745  GLU A C     1 
ATOM   3592 O O     . GLU A 1 452 ? -9.694  66.374  25.235  1.00 31.72 ? 745  GLU A O     1 
ATOM   3593 C CB    . GLU A 1 452 ? -9.643  63.045  25.081  1.00 32.07 ? 745  GLU A CB    1 
ATOM   3594 C CG    . GLU A 1 452 ? -10.196 61.952  24.191  1.00 33.55 ? 745  GLU A CG    1 
ATOM   3595 C CD    . GLU A 1 452 ? -10.598 60.670  24.914  1.00 35.25 ? 745  GLU A CD    1 
ATOM   3596 O OE1   . GLU A 1 452 ? -10.247 60.511  26.093  1.00 34.76 ? 745  GLU A OE1   1 
ATOM   3597 O OE2   . GLU A 1 452 ? -11.266 59.831  24.287  1.00 36.48 ? 745  GLU A OE2   1 
ATOM   3598 N N     . ARG A 1 453 ? -7.773  65.443  25.969  1.00 30.55 ? 746  ARG A N     1 
ATOM   3599 C CA    . ARG A 1 453 ? -7.464  66.531  26.891  1.00 34.49 ? 746  ARG A CA    1 
ATOM   3600 C C     . ARG A 1 453 ? -7.263  67.843  26.132  1.00 34.46 ? 746  ARG A C     1 
ATOM   3601 O O     . ARG A 1 453 ? -7.648  68.895  26.642  1.00 34.17 ? 746  ARG A O     1 
ATOM   3602 C CB    . ARG A 1 453 ? -6.291  66.142  27.800  1.00 35.21 ? 746  ARG A CB    1 
ATOM   3603 C CG    . ARG A 1 453 ? -6.630  64.982  28.733  1.00 37.11 ? 746  ARG A CG    1 
ATOM   3604 C CD    . ARG A 1 453 ? -5.615  64.666  29.827  1.00 38.97 ? 746  ARG A CD    1 
ATOM   3605 N NE    . ARG A 1 453 ? -4.357  64.172  29.295  1.00 42.77 ? 746  ARG A NE    1 
ATOM   3606 C CZ    . ARG A 1 453 ? -4.037  62.886  29.151  1.00 43.03 ? 746  ARG A CZ    1 
ATOM   3607 N NH1   . ARG A 1 453 ? -4.884  61.931  29.487  1.00 39.17 ? 746  ARG A NH1   1 
ATOM   3608 N NH2   . ARG A 1 453 ? -2.869  62.563  28.629  1.00 43.57 ? 746  ARG A NH2   1 
ATOM   3609 N N     . ARG A 1 454 ? -6.743  67.787  24.896  1.00 31.99 ? 747  ARG A N     1 
ATOM   3610 C CA    . ARG A 1 454 ? -6.629  68.986  24.078  1.00 32.99 ? 747  ARG A CA    1 
ATOM   3611 C C     . ARG A 1 454 ? -8.015  69.484  23.657  1.00 31.76 ? 747  ARG A C     1 
ATOM   3612 O O     . ARG A 1 454 ? -8.263  70.686  23.636  1.00 28.20 ? 747  ARG A O     1 
ATOM   3613 C CB    . ARG A 1 454 ? -5.722  68.747  22.870  1.00 35.42 ? 747  ARG A CB    1 
ATOM   3614 C CG    . ARG A 1 454 ? -4.330  68.269  23.252  1.00 38.56 ? 747  ARG A CG    1 
ATOM   3615 C CD    . ARG A 1 454 ? -3.289  68.469  22.172  1.00 41.55 ? 747  ARG A CD    1 
ATOM   3616 N NE    . ARG A 1 454 ? -3.091  67.301  21.352  1.00 47.60 ? 747  ARG A NE    1 
ATOM   3617 C CZ    . ARG A 1 454 ? -2.394  66.231  21.713  1.00 46.17 ? 747  ARG A CZ    1 
ATOM   3618 N NH1   . ARG A 1 454 ? -1.416  66.329  22.595  1.00 44.14 ? 747  ARG A NH1   1 
ATOM   3619 N NH2   . ARG A 1 454 ? -2.657  65.071  21.142  1.00 48.81 ? 747  ARG A NH2   1 
ATOM   3620 N N     . ALA A 1 455 ? -8.923  68.550  23.339  1.00 29.41 ? 748  ALA A N     1 
ATOM   3621 C CA    . ALA A 1 455 ? -10.251 68.883  22.862  1.00 27.57 ? 748  ALA A CA    1 
ATOM   3622 C C     . ALA A 1 455 ? -11.046 69.621  23.937  1.00 27.32 ? 748  ALA A C     1 
ATOM   3623 O O     . ALA A 1 455 ? -11.776 70.562  23.627  1.00 29.26 ? 748  ALA A O     1 
ATOM   3624 C CB    . ALA A 1 455 ? -10.958 67.622  22.418  1.00 29.44 ? 748  ALA A CB    1 
ATOM   3625 N N     . PHE A 1 456 ? -10.949 69.168  25.192  1.00 28.80 ? 749  PHE A N     1 
ATOM   3626 C CA    . PHE A 1 456 ? -11.631 69.825  26.303  1.00 29.77 ? 749  PHE A CA    1 
ATOM   3627 C C     . PHE A 1 456 ? -11.010 71.173  26.649  1.00 28.24 ? 749  PHE A C     1 
ATOM   3628 O O     . PHE A 1 456 ? -11.701 72.080  27.104  1.00 29.12 ? 749  PHE A O     1 
ATOM   3629 C CB    . PHE A 1 456 ? -11.503 69.011  27.591  1.00 31.29 ? 749  PHE A CB    1 
ATOM   3630 C CG    . PHE A 1 456 ? -12.044 67.612  27.510  1.00 30.78 ? 749  PHE A CG    1 
ATOM   3631 C CD1   . PHE A 1 456 ? -13.314 67.380  27.014  1.00 31.29 ? 749  PHE A CD1   1 
ATOM   3632 C CD2   . PHE A 1 456 ? -11.292 66.540  27.956  1.00 30.54 ? 749  PHE A CD2   1 
ATOM   3633 C CE1   . PHE A 1 456 ? -13.820 66.091  26.953  1.00 31.58 ? 749  PHE A CE1   1 
ATOM   3634 C CE2   . PHE A 1 456 ? -11.803 65.254  27.905  1.00 31.55 ? 749  PHE A CE2   1 
ATOM   3635 C CZ    . PHE A 1 456 ? -13.064 65.031  27.404  1.00 31.73 ? 749  PHE A CZ    1 
ATOM   3636 N N     . ASN A 1 457 ? -9.686  71.258  26.516  1.00 27.63 ? 750  ASN A N     1 
ATOM   3637 C CA    . ASN A 1 457 ? -8.922  72.423  26.945  1.00 27.91 ? 750  ASN A CA    1 
ATOM   3638 C C     . ASN A 1 457 ? -9.301  73.652  26.115  1.00 28.21 ? 750  ASN A C     1 
ATOM   3639 O O     . ASN A 1 457 ? -9.534  74.741  26.647  1.00 30.09 ? 750  ASN A O     1 
ATOM   3640 C CB    . ASN A 1 457 ? -7.417  72.159  26.812  1.00 28.56 ? 750  ASN A CB    1 
ATOM   3641 C CG    . ASN A 1 457 ? -6.552  73.294  27.312  1.00 30.66 ? 750  ASN A CG    1 
ATOM   3642 O OD1   . ASN A 1 457 ? -5.741  73.835  26.563  1.00 35.69 ? 750  ASN A OD1   1 
ATOM   3643 N ND2   . ASN A 1 457 ? -6.709  73.654  28.578  1.00 30.50 ? 750  ASN A ND2   1 
ATOM   3644 N N     . MET A 1 458 ? -9.319  73.480  24.792  1.00 26.51 ? 751  MET A N     1 
ATOM   3645 C CA    . MET A 1 458 ? -9.351  74.622  23.896  1.00 26.31 ? 751  MET A CA    1 
ATOM   3646 C C     . MET A 1 458 ? -10.655 75.420  24.049  1.00 24.87 ? 751  MET A C     1 
ATOM   3647 O O     . MET A 1 458 ? -10.610 76.637  24.195  1.00 27.04 ? 751  MET A O     1 
ATOM   3648 C CB    . MET A 1 458 ? -9.140  74.178  22.448  1.00 27.40 ? 751  MET A CB    1 
ATOM   3649 C CG    . MET A 1 458 ? -9.087  75.351  21.481  1.00 27.69 ? 751  MET A CG    1 
ATOM   3650 S SD    . MET A 1 458 ? -10.715 75.697  20.756  1.00 28.91 ? 751  MET A SD    1 
ATOM   3651 C CE    . MET A 1 458 ? -10.312 77.098  19.717  1.00 27.43 ? 751  MET A CE    1 
ATOM   3652 N N     . PRO A 1 459 ? -11.857 74.801  24.091  1.00 25.38 ? 752  PRO A N     1 
ATOM   3653 C CA    . PRO A 1 459 ? -13.098 75.557  24.266  1.00 26.35 ? 752  PRO A CA    1 
ATOM   3654 C C     . PRO A 1 459 ? -13.173 76.412  25.530  1.00 25.33 ? 752  PRO A C     1 
ATOM   3655 O O     . PRO A 1 459 ? -13.782 77.479  25.515  1.00 26.39 ? 752  PRO A O     1 
ATOM   3656 C CB    . PRO A 1 459 ? -14.191 74.470  24.340  1.00 26.90 ? 752  PRO A CB    1 
ATOM   3657 C CG    . PRO A 1 459 ? -13.601 73.297  23.604  1.00 26.48 ? 752  PRO A CG    1 
ATOM   3658 C CD    . PRO A 1 459 ? -12.119 73.365  23.906  1.00 26.79 ? 752  PRO A CD    1 
ATOM   3659 N N     . VAL A 1 460 ? -12.622 75.905  26.639  1.00 25.34 ? 753  VAL A N     1 
ATOM   3660 C CA    . VAL A 1 460 ? -12.727 76.591  27.916  1.00 25.67 ? 753  VAL A CA    1 
ATOM   3661 C C     . VAL A 1 460 ? -11.689 77.711  27.934  1.00 24.82 ? 753  VAL A C     1 
ATOM   3662 O O     . VAL A 1 460 ? -12.011 78.889  28.097  1.00 23.93 ? 753  VAL A O     1 
ATOM   3663 C CB    . VAL A 1 460 ? -12.540 75.609  29.088  1.00 25.25 ? 753  VAL A CB    1 
ATOM   3664 C CG1   . VAL A 1 460 ? -12.437 76.335  30.417  1.00 26.30 ? 753  VAL A CG1   1 
ATOM   3665 C CG2   . VAL A 1 460 ? -13.641 74.571  29.137  1.00 25.86 ? 753  VAL A CG2   1 
ATOM   3666 N N     . GLN A 1 461 ? -10.429 77.324  27.735  1.00 23.66 ? 754  GLN A N     1 
ATOM   3667 C CA    . GLN A 1 461 ? -9.333  78.274  27.798  1.00 25.11 ? 754  GLN A CA    1 
ATOM   3668 C C     . GLN A 1 461 ? -9.459  79.285  26.658  1.00 23.87 ? 754  GLN A C     1 
ATOM   3669 O O     . GLN A 1 461 ? -9.104  80.448  26.839  1.00 23.46 ? 754  GLN A O     1 
ATOM   3670 C CB    . GLN A 1 461 ? -7.988  77.540  27.755  1.00 28.73 ? 754  GLN A CB    1 
ATOM   3671 C CG    . GLN A 1 461 ? -6.788  78.466  27.856  1.00 32.37 ? 754  GLN A CG    1 
ATOM   3672 C CD    . GLN A 1 461 ? -5.491  77.696  27.808  1.00 38.06 ? 754  GLN A CD    1 
ATOM   3673 O OE1   . GLN A 1 461 ? -5.114  76.997  28.753  1.00 41.78 ? 754  GLN A OE1   1 
ATOM   3674 N NE2   . GLN A 1 461 ? -4.812  77.810  26.676  1.00 39.19 ? 754  GLN A NE2   1 
ATOM   3675 N N     . GLY A 1 462 ? -9.915  78.820  25.489  1.00 21.33 ? 755  GLY A N     1 
ATOM   3676 C CA    . GLY A 1 462 ? -10.087 79.672  24.324  1.00 24.47 ? 755  GLY A CA    1 
ATOM   3677 C C     . GLY A 1 462 ? -11.248 80.662  24.491  1.00 25.19 ? 755  GLY A C     1 
ATOM   3678 O O     . GLY A 1 462 ? -11.107 81.823  24.105  1.00 22.67 ? 755  GLY A O     1 
ATOM   3679 N N     . THR A 1 463 ? -12.379 80.214  25.075  1.00 23.84 ? 756  THR A N     1 
ATOM   3680 C CA    . THR A 1 463 ? -13.479 81.134  25.356  1.00 25.16 ? 756  THR A CA    1 
ATOM   3681 C C     . THR A 1 463 ? -13.023 82.229  26.329  1.00 24.10 ? 756  THR A C     1 
ATOM   3682 O O     . THR A 1 463 ? -13.402 83.385  26.202  1.00 27.58 ? 756  THR A O     1 
ATOM   3683 C CB    . THR A 1 463 ? -14.719 80.413  25.910  1.00 27.08 ? 756  THR A CB    1 
ATOM   3684 O OG1   . THR A 1 463 ? -15.298 79.546  24.924  1.00 24.28 ? 756  THR A OG1   1 
ATOM   3685 C CG2   . THR A 1 463 ? -15.761 81.396  26.406  1.00 27.32 ? 756  THR A CG2   1 
ATOM   3686 N N     . ALA A 1 464 ? -12.216 81.867  27.323  1.00 25.00 ? 757  ALA A N     1 
ATOM   3687 C CA    . ALA A 1 464 ? -11.750 82.812  28.326  1.00 24.22 ? 757  ALA A CA    1 
ATOM   3688 C C     . ALA A 1 464 ? -10.809 83.820  27.674  1.00 24.74 ? 757  ALA A C     1 
ATOM   3689 O O     . ALA A 1 464 ? -10.815 84.989  28.043  1.00 24.60 ? 757  ALA A O     1 
ATOM   3690 C CB    . ALA A 1 464 ? -11.071 82.094  29.471  1.00 23.24 ? 757  ALA A CB    1 
ATOM   3691 N N     . ALA A 1 465 ? -10.018 83.348  26.700  1.00 24.20 ? 758  ALA A N     1 
ATOM   3692 C CA    . ALA A 1 465 ? -9.126  84.209  25.936  1.00 23.61 ? 758  ALA A CA    1 
ATOM   3693 C C     . ALA A 1 465 ? -9.916  85.216  25.093  1.00 22.92 ? 758  ALA A C     1 
ATOM   3694 O O     . ALA A 1 465 ? -9.510  86.369  24.986  1.00 24.65 ? 758  ALA A O     1 
ATOM   3695 C CB    . ALA A 1 465 ? -8.251  83.368  25.057  1.00 24.47 ? 758  ALA A CB    1 
ATOM   3696 N N     . ASP A 1 466 ? -10.974 84.748  24.431  1.00 23.51 ? 759  ASP A N     1 
ATOM   3697 C CA    . ASP A 1 466 ? -11.831 85.567  23.566  1.00 24.83 ? 759  ASP A CA    1 
ATOM   3698 C C     . ASP A 1 466 ? -12.440 86.695  24.400  1.00 24.26 ? 759  ASP A C     1 
ATOM   3699 O O     . ASP A 1 466 ? -12.477 87.856  23.986  1.00 26.34 ? 759  ASP A O     1 
ATOM   3700 C CB    . ASP A 1 466 ? -12.941 84.718  22.917  1.00 26.25 ? 759  ASP A CB    1 
ATOM   3701 C CG    . ASP A 1 466 ? -12.551 83.681  21.861  1.00 29.95 ? 759  ASP A CG    1 
ATOM   3702 O OD1   . ASP A 1 466 ? -11.409 83.742  21.338  1.00 30.70 ? 759  ASP A OD1   1 
ATOM   3703 O OD2   . ASP A 1 466 ? -13.411 82.812  21.535  1.00 29.70 ? 759  ASP A OD2   1 
ATOM   3704 N N     . LEU A 1 467 ? -12.886 86.348  25.615  1.00 24.74 ? 760  LEU A N     1 
ATOM   3705 C CA    . LEU A 1 467 ? -13.516 87.301  26.512  1.00 25.30 ? 760  LEU A CA    1 
ATOM   3706 C C     . LEU A 1 467 ? -12.536 88.363  26.999  1.00 25.24 ? 760  LEU A C     1 
ATOM   3707 O O     . LEU A 1 467 ? -12.867 89.544  27.036  1.00 26.84 ? 760  LEU A O     1 
ATOM   3708 C CB    . LEU A 1 467 ? -14.114 86.536  27.694  1.00 26.97 ? 760  LEU A CB    1 
ATOM   3709 C CG    . LEU A 1 467 ? -15.357 85.705  27.376  1.00 26.06 ? 760  LEU A CG    1 
ATOM   3710 C CD1   . LEU A 1 467 ? -15.718 84.810  28.555  1.00 27.79 ? 760  LEU A CD1   1 
ATOM   3711 C CD2   . LEU A 1 467 ? -16.513 86.612  27.010  1.00 26.34 ? 760  LEU A CD2   1 
ATOM   3712 N N     . MET A 1 468 ? -11.344 87.944  27.415  1.00 25.37 ? 761  MET A N     1 
ATOM   3713 C CA    . MET A 1 468 ? -10.325 88.891  27.831  1.00 25.43 ? 761  MET A CA    1 
ATOM   3714 C C     . MET A 1 468 ? -9.929  89.781  26.645  1.00 24.46 ? 761  MET A C     1 
ATOM   3715 O O     . MET A 1 468 ? -9.781  90.979  26.822  1.00 26.45 ? 761  MET A O     1 
ATOM   3716 C CB    . MET A 1 468 ? -9.082  88.177  28.384  1.00 26.42 ? 761  MET A CB    1 
ATOM   3717 C CG    . MET A 1 468 ? -7.910  89.106  28.648  1.00 27.78 ? 761  MET A CG    1 
ATOM   3718 S SD    . MET A 1 468 ? -8.279  90.363  29.919  1.00 29.86 ? 761  MET A SD    1 
ATOM   3719 C CE    . MET A 1 468 ? -7.876  89.438  31.396  1.00 28.65 ? 761  MET A CE    1 
ATOM   3720 N N     . LYS A 1 469 ? -9.730  89.207  25.447  1.00 23.91 ? 762  LYS A N     1 
ATOM   3721 C CA    . LYS A 1 469 ? -9.371  90.015  24.285  1.00 24.26 ? 762  LYS A CA    1 
ATOM   3722 C C     . LYS A 1 469 ? -10.443 91.064  23.985  1.00 25.61 ? 762  LYS A C     1 
ATOM   3723 O O     . LYS A 1 469 ? -10.130 92.227  23.780  1.00 26.22 ? 762  LYS A O     1 
ATOM   3724 C CB    . LYS A 1 469 ? -9.170  89.139  23.058  1.00 24.44 ? 762  LYS A CB    1 
ATOM   3725 C CG    . LYS A 1 469 ? -7.916  88.277  23.069  1.00 25.54 ? 762  LYS A CG    1 
ATOM   3726 C CD    . LYS A 1 469 ? -7.787  87.530  21.749  1.00 26.17 ? 762  LYS A CD    1 
ATOM   3727 C CE    . LYS A 1 469 ? -6.463  86.836  21.559  1.00 25.96 ? 762  LYS A CE    1 
ATOM   3728 N NZ    . LYS A 1 469 ? -6.506  85.874  20.434  1.00 27.22 ? 762  LYS A NZ    1 
ATOM   3729 N N     . LEU A 1 470 ? -11.716 90.655  23.992  1.00 27.16 ? 763  LEU A N     1 
ATOM   3730 C CA    . LEU A 1 470 ? -12.813 91.592  23.772  1.00 27.82 ? 763  LEU A CA    1 
ATOM   3731 C C     . LEU A 1 470 ? -12.829 92.682  24.848  1.00 27.33 ? 763  LEU A C     1 
ATOM   3732 O O     . LEU A 1 470 ? -13.036 93.849  24.527  1.00 28.45 ? 763  LEU A O     1 
ATOM   3733 C CB    . LEU A 1 470 ? -14.130 90.807  23.699  1.00 28.29 ? 763  LEU A CB    1 
ATOM   3734 C CG    . LEU A 1 470 ? -15.391 91.627  23.418  1.00 29.23 ? 763  LEU A CG    1 
ATOM   3735 C CD1   . LEU A 1 470 ? -15.292 92.384  22.104  1.00 29.75 ? 763  LEU A CD1   1 
ATOM   3736 C CD2   . LEU A 1 470 ? -16.613 90.725  23.422  1.00 30.81 ? 763  LEU A CD2   1 
ATOM   3737 N N     . ALA A 1 471 ? -12.558 92.322  26.111  1.00 27.57 ? 764  ALA A N     1 
ATOM   3738 C CA    . ALA A 1 471 ? -12.486 93.297  27.193  1.00 28.16 ? 764  ALA A CA    1 
ATOM   3739 C C     . ALA A 1 471 ? -11.371 94.313  26.943  1.00 29.13 ? 764  ALA A C     1 
ATOM   3740 O O     . ALA A 1 471 ? -11.540 95.488  27.253  1.00 28.16 ? 764  ALA A O     1 
ATOM   3741 C CB    . ALA A 1 471 ? -12.267 92.615  28.522  1.00 28.76 ? 764  ALA A CB    1 
ATOM   3742 N N     . MET A 1 472 ? -10.220 93.852  26.423  1.00 25.83 ? 765  MET A N     1 
ATOM   3743 C CA    . MET A 1 472 ? -9.090  94.743  26.182  1.00 26.93 ? 765  MET A CA    1 
ATOM   3744 C C     . MET A 1 472 ? -9.465  95.765  25.107  1.00 26.07 ? 765  MET A C     1 
ATOM   3745 O O     . MET A 1 472 ? -9.109  96.939  25.214  1.00 27.20 ? 765  MET A O     1 
ATOM   3746 C CB    . MET A 1 472 ? -7.845  93.956  25.740  1.00 25.09 ? 765  MET A CB    1 
ATOM   3747 C CG    . MET A 1 472 ? -7.244  93.131  26.871  1.00 26.60 ? 765  MET A CG    1 
ATOM   3748 S SD    . MET A 1 472 ? -5.964  91.978  26.342  1.00 25.19 ? 765  MET A SD    1 
ATOM   3749 C CE    . MET A 1 472 ? -4.634  93.137  26.009  1.00 26.61 ? 765  MET A CE    1 
ATOM   3750 N N     . VAL A 1 473 ? -10.166 95.287  24.074  1.00 27.98 ? 766  VAL A N     1 
ATOM   3751 C CA    . VAL A 1 473 ? -10.589 96.094  22.936  1.00 30.38 ? 766  VAL A CA    1 
ATOM   3752 C C     . VAL A 1 473 ? -11.574 97.157  23.429  1.00 30.25 ? 766  VAL A C     1 
ATOM   3753 O O     . VAL A 1 473 ? -11.492 98.313  23.036  1.00 31.40 ? 766  VAL A O     1 
ATOM   3754 C CB    . VAL A 1 473 ? -11.194 95.201  21.831  1.00 29.50 ? 766  VAL A CB    1 
ATOM   3755 C CG1   . VAL A 1 473 ? -12.001 95.982  20.801  1.00 31.41 ? 766  VAL A CG1   1 
ATOM   3756 C CG2   . VAL A 1 473 ? -10.132 94.375  21.125  1.00 28.88 ? 766  VAL A CG2   1 
ATOM   3757 N N     . LYS A 1 474 ? -12.488 96.763  24.315  1.00 31.41 ? 767  LYS A N     1 
ATOM   3758 C CA    . LYS A 1 474 ? -13.497 97.675  24.836  1.00 31.00 ? 767  LYS A CA    1 
ATOM   3759 C C     . LYS A 1 474 ? -12.888 98.693  25.790  1.00 31.37 ? 767  LYS A C     1 
ATOM   3760 O O     . LYS A 1 474 ? -13.305 99.846  25.793  1.00 33.92 ? 767  LYS A O     1 
ATOM   3761 C CB    . LYS A 1 474 ? -14.608 96.905  25.547  1.00 33.01 ? 767  LYS A CB    1 
ATOM   3762 C CG    . LYS A 1 474 ? -15.467 96.071  24.618  1.00 35.44 ? 767  LYS A CG    1 
ATOM   3763 C CD    . LYS A 1 474 ? -16.708 95.531  25.271  1.00 38.62 ? 767  LYS A CD    1 
ATOM   3764 C CE    . LYS A 1 474 ? -17.705 95.038  24.245  1.00 41.29 ? 767  LYS A CE    1 
ATOM   3765 N NZ    . LYS A 1 474 ? -18.867 94.403  24.903  1.00 46.75 ? 767  LYS A NZ    1 
ATOM   3766 N N     . LEU A 1 475 ? -11.892 98.281  26.581  1.00 31.46 ? 768  LEU A N     1 
ATOM   3767 C CA    . LEU A 1 475 ? -11.408 99.098  27.682  1.00 34.05 ? 768  LEU A CA    1 
ATOM   3768 C C     . LEU A 1 475 ? -10.406 100.132 27.185  1.00 34.60 ? 768  LEU A C     1 
ATOM   3769 O O     . LEU A 1 475 ? -10.340 101.243 27.708  1.00 30.32 ? 768  LEU A O     1 
ATOM   3770 C CB    . LEU A 1 475 ? -10.781 98.184  28.745  1.00 34.91 ? 768  LEU A CB    1 
ATOM   3771 C CG    . LEU A 1 475 ? -10.174 98.878  29.960  1.00 36.20 ? 768  LEU A CG    1 
ATOM   3772 C CD1   . LEU A 1 475 ? -11.193 99.776  30.663  1.00 36.34 ? 768  LEU A CD1   1 
ATOM   3773 C CD2   . LEU A 1 475 ? -9.614  97.842  30.929  1.00 38.58 ? 768  LEU A CD2   1 
ATOM   3774 N N     . PHE A 1 476 ? -9.621  99.752  26.173  1.00 34.62 ? 769  PHE A N     1 
ATOM   3775 C CA    . PHE A 1 476 ? -8.438  100.514 25.815  1.00 35.94 ? 769  PHE A CA    1 
ATOM   3776 C C     . PHE A 1 476 ? -8.786  101.965 25.452  1.00 37.66 ? 769  PHE A C     1 
ATOM   3777 O O     . PHE A 1 476 ? -8.134  102.897 25.919  1.00 37.82 ? 769  PHE A O     1 
ATOM   3778 C CB    . PHE A 1 476 ? -7.683  99.821  24.681  1.00 37.74 ? 769  PHE A CB    1 
ATOM   3779 C CG    . PHE A 1 476 ? -6.501  100.643 24.260  1.00 39.37 ? 769  PHE A CG    1 
ATOM   3780 C CD1   . PHE A 1 476 ? -5.412  100.773 25.100  1.00 40.28 ? 769  PHE A CD1   1 
ATOM   3781 C CD2   . PHE A 1 476 ? -6.531  101.378 23.091  1.00 39.42 ? 769  PHE A CD2   1 
ATOM   3782 C CE1   . PHE A 1 476 ? -4.342  101.580 24.750  1.00 43.59 ? 769  PHE A CE1   1 
ATOM   3783 C CE2   . PHE A 1 476 ? -5.458  102.179 22.742  1.00 41.96 ? 769  PHE A CE2   1 
ATOM   3784 C CZ    . PHE A 1 476 ? -4.375  102.290 23.577  1.00 41.66 ? 769  PHE A CZ    1 
ATOM   3785 N N     . PRO A 1 477 ? -9.776  102.241 24.577  1.00 38.46 ? 770  PRO A N     1 
ATOM   3786 C CA    . PRO A 1 477 ? -10.122 103.628 24.262  1.00 42.77 ? 770  PRO A CA    1 
ATOM   3787 C C     . PRO A 1 477 ? -10.578 104.428 25.488  1.00 45.79 ? 770  PRO A C     1 
ATOM   3788 O O     . PRO A 1 477 ? -10.261 105.608 25.598  1.00 47.69 ? 770  PRO A O     1 
ATOM   3789 C CB    . PRO A 1 477 ? -11.230 103.508 23.207  1.00 40.37 ? 770  PRO A CB    1 
ATOM   3790 C CG    . PRO A 1 477 ? -11.756 102.108 23.353  1.00 40.62 ? 770  PRO A CG    1 
ATOM   3791 C CD    . PRO A 1 477 ? -10.569 101.279 23.801  1.00 40.03 ? 770  PRO A CD    1 
ATOM   3792 N N     . ARG A 1 478 ? -11.287 103.764 26.417  1.00 47.28 ? 771  ARG A N     1 
ATOM   3793 C CA    . ARG A 1 478 ? -11.756 104.379 27.650  1.00 44.82 ? 771  ARG A CA    1 
ATOM   3794 C C     . ARG A 1 478 ? -10.559 104.813 28.491  1.00 44.57 ? 771  ARG A C     1 
ATOM   3795 O O     . ARG A 1 478 ? -10.561 105.917 29.020  1.00 43.82 ? 771  ARG A O     1 
ATOM   3796 C CB    . ARG A 1 478 ? -12.657 103.422 28.441  1.00 48.92 ? 771  ARG A CB    1 
ATOM   3797 C CG    . ARG A 1 478 ? -13.843 102.863 27.664  1.00 52.29 ? 771  ARG A CG    1 
ATOM   3798 C CD    . ARG A 1 478 ? -15.044 103.788 27.616  1.00 57.03 ? 771  ARG A CD    1 
ATOM   3799 N NE    . ARG A 1 478 ? -16.012 103.487 28.667  1.00 66.42 ? 771  ARG A NE    1 
ATOM   3800 C CZ    . ARG A 1 478 ? -16.779 102.396 28.703  1.00 68.14 ? 771  ARG A CZ    1 
ATOM   3801 N NH1   . ARG A 1 478 ? -17.527 102.142 29.765  1.00 68.66 ? 771  ARG A NH1   1 
ATOM   3802 N NH2   . ARG A 1 478 ? -16.791 101.555 27.681  1.00 65.20 ? 771  ARG A NH2   1 
ATOM   3803 N N     . LEU A 1 479 ? -9.529  103.957 28.596  1.00 42.37 ? 772  LEU A N     1 
ATOM   3804 C CA    . LEU A 1 479 ? -8.328  104.293 29.346  1.00 41.92 ? 772  LEU A CA    1 
ATOM   3805 C C     . LEU A 1 479 ? -7.616  105.488 28.723  1.00 44.09 ? 772  LEU A C     1 
ATOM   3806 O O     . LEU A 1 479 ? -7.159  106.373 29.447  1.00 38.03 ? 772  LEU A O     1 
ATOM   3807 C CB    . LEU A 1 479 ? -7.357  103.109 29.375  1.00 42.96 ? 772  LEU A CB    1 
ATOM   3808 C CG    . LEU A 1 479 ? -7.786  101.885 30.173  1.00 43.11 ? 772  LEU A CG    1 
ATOM   3809 C CD1   . LEU A 1 479 ? -6.659  100.867 30.186  1.00 41.58 ? 772  LEU A CD1   1 
ATOM   3810 C CD2   . LEU A 1 479 ? -8.195  102.253 31.592  1.00 42.26 ? 772  LEU A CD2   1 
ATOM   3811 N N     . GLU A 1 480 ? -7.458  105.463 27.391  1.00 50.37 ? 773  GLU A N     1 
ATOM   3812 C CA    . GLU A 1 480 ? -6.814  106.557 26.674  1.00 53.63 ? 773  GLU A CA    1 
ATOM   3813 C C     . GLU A 1 480 ? -7.440  107.885 27.092  1.00 51.27 ? 773  GLU A C     1 
ATOM   3814 O O     . GLU A 1 480 ? -6.716  108.831 27.372  1.00 51.18 ? 773  GLU A O     1 
ATOM   3815 C CB    . GLU A 1 480 ? -6.920  106.389 25.156  1.00 56.60 ? 773  GLU A CB    1 
ATOM   3816 C CG    . GLU A 1 480 ? -5.880  105.452 24.569  1.00 61.28 ? 773  GLU A CG    1 
ATOM   3817 C CD    . GLU A 1 480 ? -5.787  105.517 23.054  1.00 64.10 ? 773  GLU A CD    1 
ATOM   3818 O OE1   . GLU A 1 480 ? -6.846  105.447 22.396  1.00 69.76 ? 773  GLU A OE1   1 
ATOM   3819 O OE2   . GLU A 1 480 ? -4.656  105.636 22.535  1.00 67.22 ? 773  GLU A OE2   1 
ATOM   3820 N N     . GLU A 1 481 ? -8.779  107.926 27.168  1.00 53.08 ? 774  GLU A N     1 
ATOM   3821 C CA    . GLU A 1 481 ? -9.508  109.136 27.526  1.00 58.72 ? 774  GLU A CA    1 
ATOM   3822 C C     . GLU A 1 481 ? -9.142  109.637 28.924  1.00 58.06 ? 774  GLU A C     1 
ATOM   3823 O O     . GLU A 1 481 ? -9.144  110.842 29.152  1.00 57.61 ? 774  GLU A O     1 
ATOM   3824 C CB    . GLU A 1 481 ? -11.018 108.903 27.455  1.00 63.48 ? 774  GLU A CB    1 
ATOM   3825 C CG    . GLU A 1 481 ? -11.515 108.597 26.055  1.00 69.05 ? 774  GLU A CG    1 
ATOM   3826 C CD    . GLU A 1 481 ? -13.026 108.500 25.929  1.00 73.39 ? 774  GLU A CD    1 
ATOM   3827 O OE1   . GLU A 1 481 ? -13.627 107.642 26.610  1.00 73.85 ? 774  GLU A OE1   1 
ATOM   3828 O OE2   . GLU A 1 481 ? -13.597 109.287 25.149  1.00 80.68 ? 774  GLU A OE2   1 
ATOM   3829 N N     . MET A 1 482 ? -8.836  108.722 29.856  1.00 56.10 ? 775  MET A N     1 
ATOM   3830 C CA    . MET A 1 482 ? -8.598  109.076 31.248  1.00 52.04 ? 775  MET A CA    1 
ATOM   3831 C C     . MET A 1 482 ? -7.111  109.308 31.514  1.00 47.64 ? 775  MET A C     1 
ATOM   3832 O O     . MET A 1 482 ? -6.728  109.601 32.645  1.00 52.98 ? 775  MET A O     1 
ATOM   3833 C CB    . MET A 1 482 ? -9.104  107.961 32.167  1.00 53.70 ? 775  MET A CB    1 
ATOM   3834 C CG    . MET A 1 482 ? -10.610 107.889 32.219  1.00 56.40 ? 775  MET A CG    1 
ATOM   3835 S SD    . MET A 1 482 ? -11.193 106.463 33.159  1.00 63.62 ? 775  MET A SD    1 
ATOM   3836 C CE    . MET A 1 482 ? -11.328 107.194 34.790  1.00 59.14 ? 775  MET A CE    1 
ATOM   3837 N N     . GLY A 1 483 ? -6.263  109.164 30.491  1.00 44.43 ? 776  GLY A N     1 
ATOM   3838 C CA    . GLY A 1 483 ? -4.833  109.397 30.649  1.00 42.58 ? 776  GLY A CA    1 
ATOM   3839 C C     . GLY A 1 483 ? -4.111  108.218 31.307  1.00 40.34 ? 776  GLY A C     1 
ATOM   3840 O O     . GLY A 1 483 ? -3.014  108.373 31.855  1.00 37.39 ? 776  GLY A O     1 
ATOM   3841 N N     . ALA A 1 484 ? -4.738  107.038 31.239  1.00 38.40 ? 777  ALA A N     1 
ATOM   3842 C CA    . ALA A 1 484 ? -4.183  105.823 31.819  1.00 39.53 ? 777  ALA A CA    1 
ATOM   3843 C C     . ALA A 1 484 ? -3.598  104.946 30.709  1.00 38.37 ? 777  ALA A C     1 
ATOM   3844 O O     . ALA A 1 484 ? -3.915  105.159 29.540  1.00 34.96 ? 777  ALA A O     1 
ATOM   3845 C CB    . ALA A 1 484 ? -5.264  105.101 32.598  1.00 39.80 ? 777  ALA A CB    1 
ATOM   3846 N N     . ARG A 1 485 ? -2.780  103.950 31.103  1.00 37.22 ? 778  ARG A N     1 
ATOM   3847 C CA    . ARG A 1 485 ? -2.120  103.026 30.184  1.00 36.19 ? 778  ARG A CA    1 
ATOM   3848 C C     . ARG A 1 485 ? -2.499  101.575 30.498  1.00 37.58 ? 778  ARG A C     1 
ATOM   3849 O O     . ARG A 1 485 ? -2.757  101.212 31.651  1.00 31.88 ? 778  ARG A O     1 
ATOM   3850 C CB    . ARG A 1 485 ? -0.597  103.118 30.308  1.00 35.45 ? 778  ARG A CB    1 
ATOM   3851 C CG    . ARG A 1 485 ? -0.017  104.506 30.066  1.00 36.92 ? 778  ARG A CG    1 
ATOM   3852 C CD    . ARG A 1 485 ? 1.316   104.669 30.759  1.00 39.06 ? 778  ARG A CD    1 
ATOM   3853 N NE    . ARG A 1 485 ? 1.869   106.003 30.617  1.00 39.61 ? 778  ARG A NE    1 
ATOM   3854 C CZ    . ARG A 1 485 ? 2.930   106.437 31.275  1.00 40.41 ? 778  ARG A CZ    1 
ATOM   3855 N NH1   . ARG A 1 485 ? 3.581   105.626 32.084  1.00 36.73 ? 778  ARG A NH1   1 
ATOM   3856 N NH2   . ARG A 1 485 ? 3.337   107.685 31.114  1.00 45.48 ? 778  ARG A NH2   1 
ATOM   3857 N N     . MET A 1 486 ? -2.435  100.730 29.463  1.00 36.28 ? 779  MET A N     1 
ATOM   3858 C CA    . MET A 1 486 ? -2.549  99.295  29.635  1.00 34.20 ? 779  MET A CA    1 
ATOM   3859 C C     . MET A 1 486 ? -1.159  98.685  29.438  1.00 33.77 ? 779  MET A C     1 
ATOM   3860 O O     . MET A 1 486 ? -0.555  98.892  28.386  1.00 37.40 ? 779  MET A O     1 
ATOM   3861 C CB    . MET A 1 486 ? -3.579  98.751  28.639  1.00 33.17 ? 779  MET A CB    1 
ATOM   3862 C CG    . MET A 1 486 ? -3.750  97.245  28.688  1.00 35.61 ? 779  MET A CG    1 
ATOM   3863 S SD    . MET A 1 486 ? -5.100  96.657  27.663  1.00 35.64 ? 779  MET A SD    1 
ATOM   3864 C CE    . MET A 1 486 ? -6.484  97.624  28.259  1.00 36.91 ? 779  MET A CE    1 
ATOM   3865 N N     . LEU A 1 487 ? -0.643  97.963  30.451  1.00 29.03 ? 780  LEU A N     1 
ATOM   3866 C CA    . LEU A 1 487 ? 0.746   97.506  30.454  1.00 30.02 ? 780  LEU A CA    1 
ATOM   3867 C C     . LEU A 1 487 ? 0.875   96.007  30.166  1.00 30.10 ? 780  LEU A C     1 
ATOM   3868 O O     . LEU A 1 487 ? 1.642   95.639  29.283  1.00 32.35 ? 780  LEU A O     1 
ATOM   3869 C CB    . LEU A 1 487 ? 1.398   97.807  31.808  1.00 30.90 ? 780  LEU A CB    1 
ATOM   3870 C CG    . LEU A 1 487 ? 1.493   99.280  32.203  1.00 32.27 ? 780  LEU A CG    1 
ATOM   3871 C CD1   . LEU A 1 487 ? 2.438   99.437  33.374  1.00 33.68 ? 780  LEU A CD1   1 
ATOM   3872 C CD2   . LEU A 1 487 ? 1.940   100.149 31.033  1.00 32.43 ? 780  LEU A CD2   1 
ATOM   3873 N N     . LEU A 1 488 ? 0.197   95.137  30.938  1.00 27.12 ? 781  LEU A N     1 
ATOM   3874 C CA    . LEU A 1 488 ? 0.419   93.701  30.789  1.00 28.00 ? 781  LEU A CA    1 
ATOM   3875 C C     . LEU A 1 488 ? -0.915  92.964  30.735  1.00 27.80 ? 781  LEU A C     1 
ATOM   3876 O O     . LEU A 1 488 ? -1.908  93.426  31.305  1.00 26.23 ? 781  LEU A O     1 
ATOM   3877 C CB    . LEU A 1 488 ? 1.257   93.145  31.947  1.00 28.54 ? 781  LEU A CB    1 
ATOM   3878 C CG    . LEU A 1 488 ? 2.593   93.819  32.245  1.00 29.97 ? 781  LEU A CG    1 
ATOM   3879 C CD1   . LEU A 1 488 ? 3.104   93.398  33.604  1.00 32.65 ? 781  LEU A CD1   1 
ATOM   3880 C CD2   . LEU A 1 488 ? 3.626   93.503  31.184  1.00 32.96 ? 781  LEU A CD2   1 
ATOM   3881 N N     . GLN A 1 489 ? -0.893  91.799  30.061  1.00 25.57 ? 782  GLN A N     1 
ATOM   3882 C CA    . GLN A 1 489 ? -1.962  90.812  30.119  1.00 23.75 ? 782  GLN A CA    1 
ATOM   3883 C C     . GLN A 1 489 ? -1.321  89.482  30.514  1.00 23.51 ? 782  GLN A C     1 
ATOM   3884 O O     . GLN A 1 489 ? -0.276  89.123  29.975  1.00 24.52 ? 782  GLN A O     1 
ATOM   3885 C CB    . GLN A 1 489 ? -2.692  90.763  28.774  1.00 24.79 ? 782  GLN A CB    1 
ATOM   3886 C CG    . GLN A 1 489 ? -3.956  89.893  28.740  1.00 24.38 ? 782  GLN A CG    1 
ATOM   3887 C CD    . GLN A 1 489 ? -3.758  88.500  28.179  1.00 24.97 ? 782  GLN A CD    1 
ATOM   3888 O OE1   . GLN A 1 489 ? -2.734  87.861  28.392  1.00 25.05 ? 782  GLN A OE1   1 
ATOM   3889 N NE2   . GLN A 1 489 ? -4.735  88.009  27.434  1.00 24.98 ? 782  GLN A NE2   1 
ATOM   3890 N N     . VAL A 1 490 ? -1.902  88.795  31.506  1.00 23.36 ? 783  VAL A N     1 
ATOM   3891 C CA    . VAL A 1 490 ? -1.468  87.453  31.885  1.00 22.89 ? 783  VAL A CA    1 
ATOM   3892 C C     . VAL A 1 490 ? -2.714  86.551  31.913  1.00 22.78 ? 783  VAL A C     1 
ATOM   3893 O O     . VAL A 1 490 ? -3.142  86.068  32.967  1.00 22.67 ? 783  VAL A O     1 
ATOM   3894 C CB    . VAL A 1 490 ? -0.672  87.452  33.208  1.00 23.61 ? 783  VAL A CB    1 
ATOM   3895 C CG1   . VAL A 1 490 ? 0.090   86.150  33.425  1.00 25.19 ? 783  VAL A CG1   1 
ATOM   3896 C CG2   . VAL A 1 490 ? 0.303   88.622  33.308  1.00 24.73 ? 783  VAL A CG2   1 
ATOM   3897 N N     . HIS A 1 491 ? -3.280  86.349  30.717  1.00 22.73 ? 784  HIS A N     1 
ATOM   3898 C CA    . HIS A 1 491 ? -4.363  85.413  30.427  1.00 24.84 ? 784  HIS A CA    1 
ATOM   3899 C C     . HIS A 1 491 ? -5.690  85.829  31.070  1.00 26.79 ? 784  HIS A C     1 
ATOM   3900 O O     . HIS A 1 491 ? -6.630  86.156  30.350  1.00 27.44 ? 784  HIS A O     1 
ATOM   3901 C CB    . HIS A 1 491 ? -3.946  83.980  30.793  1.00 24.71 ? 784  HIS A CB    1 
ATOM   3902 C CG    . HIS A 1 491 ? -2.608  83.614  30.231  1.00 23.69 ? 784  HIS A CG    1 
ATOM   3903 N ND1   . HIS A 1 491 ? -2.275  83.755  28.901  1.00 25.12 ? 784  HIS A ND1   1 
ATOM   3904 C CD2   . HIS A 1 491 ? -1.499  83.160  30.865  1.00 24.83 ? 784  HIS A CD2   1 
ATOM   3905 C CE1   . HIS A 1 491 ? -1.017  83.365  28.725  1.00 24.24 ? 784  HIS A CE1   1 
ATOM   3906 N NE2   . HIS A 1 491 ? -0.518  82.987  29.923  1.00 24.05 ? 784  HIS A NE2   1 
ATOM   3907 N N     . ASP A 1 492 ? -5.808  85.756  32.405  1.00 28.53 ? 785  ASP A N     1 
ATOM   3908 C CA    . ASP A 1 492 ? -7.026  86.199  33.081  1.00 29.73 ? 785  ASP A CA    1 
ATOM   3909 C C     . ASP A 1 492 ? -6.801  87.530  33.804  1.00 30.20 ? 785  ASP A C     1 
ATOM   3910 O O     . ASP A 1 492 ? -7.722  88.022  34.459  1.00 31.17 ? 785  ASP A O     1 
ATOM   3911 C CB    . ASP A 1 492 ? -7.538  85.165  34.093  1.00 31.74 ? 785  ASP A CB    1 
ATOM   3912 C CG    . ASP A 1 492 ? -6.592  84.928  35.263  1.00 33.93 ? 785  ASP A CG    1 
ATOM   3913 O OD1   . ASP A 1 492 ? -5.392  85.220  35.104  1.00 34.74 ? 785  ASP A OD1   1 
ATOM   3914 O OD2   . ASP A 1 492 ? -7.057  84.461  36.331  1.00 34.84 ? 785  ASP A OD2   1 
ATOM   3915 N N     . GLU A 1 493 ? -5.595  88.106  33.683  1.00 29.54 ? 786  GLU A N     1 
ATOM   3916 C CA    . GLU A 1 493 ? -5.222  89.307  34.427  1.00 30.78 ? 786  GLU A CA    1 
ATOM   3917 C C     . GLU A 1 493 ? -4.827  90.435  33.475  1.00 29.77 ? 786  GLU A C     1 
ATOM   3918 O O     . GLU A 1 493 ? -4.264  90.183  32.403  1.00 26.36 ? 786  GLU A O     1 
ATOM   3919 C CB    . GLU A 1 493 ? -4.024  89.064  35.348  1.00 35.32 ? 786  GLU A CB    1 
ATOM   3920 C CG    . GLU A 1 493 ? -4.066  87.735  36.076  1.00 41.52 ? 786  GLU A CG    1 
ATOM   3921 C CD    . GLU A 1 493 ? -2.915  87.452  37.027  1.00 44.50 ? 786  GLU A CD    1 
ATOM   3922 O OE1   . GLU A 1 493 ? -3.046  86.453  37.781  1.00 45.68 ? 786  GLU A OE1   1 
ATOM   3923 O OE2   . GLU A 1 493 ? -1.896  88.223  37.017  1.00 41.61 ? 786  GLU A OE2   1 
ATOM   3924 N N     . LEU A 1 494 ? -5.120  91.673  33.901  1.00 28.77 ? 787  LEU A N     1 
ATOM   3925 C CA    . LEU A 1 494 ? -4.652  92.885  33.240  1.00 30.39 ? 787  LEU A CA    1 
ATOM   3926 C C     . LEU A 1 494 ? -3.965  93.774  34.262  1.00 28.83 ? 787  LEU A C     1 
ATOM   3927 O O     . LEU A 1 494 ? -4.478  93.934  35.377  1.00 29.23 ? 787  LEU A O     1 
ATOM   3928 C CB    . LEU A 1 494 ? -5.825  93.671  32.652  1.00 31.82 ? 787  LEU A CB    1 
ATOM   3929 C CG    . LEU A 1 494 ? -6.428  93.163  31.351  1.00 36.98 ? 787  LEU A CG    1 
ATOM   3930 C CD1   . LEU A 1 494 ? -7.512  94.137  30.882  1.00 35.38 ? 787  LEU A CD1   1 
ATOM   3931 C CD2   . LEU A 1 494 ? -5.347  92.961  30.285  1.00 36.21 ? 787  LEU A CD2   1 
ATOM   3932 N N     . VAL A 1 495 ? -2.845  94.383  33.854  1.00 27.55 ? 788  VAL A N     1 
ATOM   3933 C CA    . VAL A 1 495 ? -2.165  95.373  34.681  1.00 29.54 ? 788  VAL A CA    1 
ATOM   3934 C C     . VAL A 1 495 ? -2.178  96.704  33.938  1.00 29.45 ? 788  VAL A C     1 
ATOM   3935 O O     . VAL A 1 495 ? -1.669  96.800  32.825  1.00 27.69 ? 788  VAL A O     1 
ATOM   3936 C CB    . VAL A 1 495 ? -0.726  94.978  35.057  1.00 30.79 ? 788  VAL A CB    1 
ATOM   3937 C CG1   . VAL A 1 495 ? -0.076  96.051  35.916  1.00 32.78 ? 788  VAL A CG1   1 
ATOM   3938 C CG2   . VAL A 1 495 ? -0.654  93.634  35.761  1.00 32.91 ? 788  VAL A CG2   1 
ATOM   3939 N N     . LEU A 1 496 ? -2.830  97.695  34.556  1.00 30.88 ? 789  LEU A N     1 
ATOM   3940 C CA    . LEU A 1 496 ? -2.907  99.050  34.032  1.00 30.35 ? 789  LEU A CA    1 
ATOM   3941 C C     . LEU A 1 496 ? -1.979  99.943  34.852  1.00 30.75 ? 789  LEU A C     1 
ATOM   3942 O O     . LEU A 1 496 ? -1.507  99.533  35.910  1.00 31.16 ? 789  LEU A O     1 
ATOM   3943 C CB    . LEU A 1 496 ? -4.354  99.546  34.146  1.00 30.44 ? 789  LEU A CB    1 
ATOM   3944 C CG    . LEU A 1 496 ? -5.454  98.563  33.745  1.00 31.99 ? 789  LEU A CG    1 
ATOM   3945 C CD1   . LEU A 1 496 ? -6.823  99.191  33.945  1.00 32.16 ? 789  LEU A CD1   1 
ATOM   3946 C CD2   . LEU A 1 496 ? -5.299  98.085  32.302  1.00 31.78 ? 789  LEU A CD2   1 
ATOM   3947 N N     . GLU A 1 497 ? -1.745  101.163 34.363  1.00 31.84 ? 790  GLU A N     1 
ATOM   3948 C CA    . GLU A 1 497 ? -0.970  102.176 35.068  1.00 32.86 ? 790  GLU A CA    1 
ATOM   3949 C C     . GLU A 1 497 ? -1.722  103.501 34.932  1.00 35.64 ? 790  GLU A C     1 
ATOM   3950 O O     . GLU A 1 497 ? -2.096  103.873 33.826  1.00 35.53 ? 790  GLU A O     1 
ATOM   3951 C CB    . GLU A 1 497 ? 0.432   102.253 34.476  1.00 35.25 ? 790  GLU A CB    1 
ATOM   3952 C CG    . GLU A 1 497 ? 1.459   103.038 35.291  1.00 36.24 ? 790  GLU A CG    1 
ATOM   3953 C CD    . GLU A 1 497 ? 2.793   103.154 34.568  1.00 39.18 ? 790  GLU A CD    1 
ATOM   3954 O OE1   . GLU A 1 497 ? 2.772   103.362 33.329  1.00 39.13 ? 790  GLU A OE1   1 
ATOM   3955 O OE2   . GLU A 1 497 ? 3.846   103.011 35.222  1.00 41.24 ? 790  GLU A OE2   1 
ATOM   3956 N N     . ALA A 1 498 ? -1.990  104.179 36.060  1.00 35.68 ? 791  ALA A N     1 
ATOM   3957 C CA    . ALA A 1 498 ? -2.786  105.404 36.060  1.00 35.58 ? 791  ALA A CA    1 
ATOM   3958 C C     . ALA A 1 498 ? -2.146  106.461 36.958  1.00 37.10 ? 791  ALA A C     1 
ATOM   3959 O O     . ALA A 1 498 ? -1.520  106.134 37.972  1.00 37.28 ? 791  ALA A O     1 
ATOM   3960 C CB    . ALA A 1 498 ? -4.191  105.113 36.511  1.00 35.36 ? 791  ALA A CB    1 
ATOM   3961 N N     . PRO A 1 499 ? -2.275  107.768 36.631  1.00 39.50 ? 792  PRO A N     1 
ATOM   3962 C CA    . PRO A 1 499 ? -1.800  108.816 37.534  1.00 43.02 ? 792  PRO A CA    1 
ATOM   3963 C C     . PRO A 1 499 ? -2.514  108.585 38.866  1.00 38.92 ? 792  PRO A C     1 
ATOM   3964 O O     . PRO A 1 499 ? -3.690  108.226 38.875  1.00 36.97 ? 792  PRO A O     1 
ATOM   3965 C CB    . PRO A 1 499 ? -2.174  110.131 36.829  1.00 44.40 ? 792  PRO A CB    1 
ATOM   3966 C CG    . PRO A 1 499 ? -2.372  109.727 35.376  1.00 45.32 ? 792  PRO A CG    1 
ATOM   3967 C CD    . PRO A 1 499 ? -2.931  108.318 35.436  1.00 42.82 ? 792  PRO A CD    1 
ATOM   3968 N N     . LYS A 1 500 ? -1.786  108.755 39.974  1.00 42.63 ? 793  LYS A N     1 
ATOM   3969 C CA    . LYS A 1 500 ? -2.238  108.265 41.269  1.00 47.19 ? 793  LYS A CA    1 
ATOM   3970 C C     . LYS A 1 500 ? -3.592  108.861 41.655  1.00 45.14 ? 793  LYS A C     1 
ATOM   3971 O O     . LYS A 1 500 ? -4.387  108.173 42.298  1.00 48.94 ? 793  LYS A O     1 
ATOM   3972 C CB    . LYS A 1 500 ? -1.179  108.494 42.351  1.00 50.65 ? 793  LYS A CB    1 
ATOM   3973 C CG    . LYS A 1 500 ? -0.917  109.945 42.727  1.00 54.08 ? 793  LYS A CG    1 
ATOM   3974 C CD    . LYS A 1 500 ? 0.008   110.062 43.906  1.00 56.11 ? 793  LYS A CD    1 
ATOM   3975 C CE    . LYS A 1 500 ? 0.409   111.489 44.208  1.00 58.65 ? 793  LYS A CE    1 
ATOM   3976 N NZ    . LYS A 1 500 ? 1.155   111.560 45.483  1.00 60.31 ? 793  LYS A NZ    1 
ATOM   3977 N N     . GLU A 1 501 ? -3.882  110.096 41.216  1.00 44.96 ? 794  GLU A N     1 
ATOM   3978 C CA    . GLU A 1 501 ? -5.136  110.760 41.559  1.00 47.91 ? 794  GLU A CA    1 
ATOM   3979 C C     . GLU A 1 501 ? -6.321  110.088 40.859  1.00 47.00 ? 794  GLU A C     1 
ATOM   3980 O O     . GLU A 1 501 ? -7.435  110.127 41.370  1.00 48.90 ? 794  GLU A O     1 
ATOM   3981 C CB    . GLU A 1 501 ? -5.163  112.246 41.178  1.00 52.97 ? 794  GLU A CB    1 
ATOM   3982 C CG    . GLU A 1 501 ? -3.808  112.936 41.152  1.00 59.00 ? 794  GLU A CG    1 
ATOM   3983 C CD    . GLU A 1 501 ? -3.042  112.735 39.850  1.00 60.06 ? 794  GLU A CD    1 
ATOM   3984 O OE1   . GLU A 1 501 ? -1.944  112.145 39.894  1.00 55.58 ? 794  GLU A OE1   1 
ATOM   3985 O OE2   . GLU A 1 501 ? -3.556  113.148 38.790  1.00 67.22 ? 794  GLU A OE2   1 
ATOM   3986 N N     . ARG A 1 502 ? -6.099  109.479 39.688  1.00 43.42 ? 795  ARG A N     1 
ATOM   3987 C CA    . ARG A 1 502 ? -7.192  108.920 38.900  1.00 44.00 ? 795  ARG A CA    1 
ATOM   3988 C C     . ARG A 1 502 ? -7.249  107.393 39.018  1.00 39.98 ? 795  ARG A C     1 
ATOM   3989 O O     . ARG A 1 502 ? -8.141  106.777 38.450  1.00 37.44 ? 795  ARG A O     1 
ATOM   3990 C CB    . ARG A 1 502 ? -7.016  109.318 37.429  1.00 49.02 ? 795  ARG A CB    1 
ATOM   3991 C CG    . ARG A 1 502 ? -6.481  110.730 37.238  1.00 55.50 ? 795  ARG A CG    1 
ATOM   3992 C CD    . ARG A 1 502 ? -6.236  111.118 35.793  1.00 61.44 ? 795  ARG A CD    1 
ATOM   3993 N NE    . ARG A 1 502 ? -7.362  111.820 35.201  1.00 65.95 ? 795  ARG A NE    1 
ATOM   3994 C CZ    . ARG A 1 502 ? -7.344  112.383 33.999  1.00 71.53 ? 795  ARG A CZ    1 
ATOM   3995 N NH1   . ARG A 1 502 ? -8.480  112.698 33.400  1.00 75.29 ? 795  ARG A NH1   1 
ATOM   3996 N NH2   . ARG A 1 502 ? -6.190  112.592 33.384  1.00 69.83 ? 795  ARG A NH2   1 
ATOM   3997 N N     . ALA A 1 503 ? -6.285  106.785 39.723  1.00 40.54 ? 796  ALA A N     1 
ATOM   3998 C CA    . ALA A 1 503 ? -6.102  105.337 39.733  1.00 40.42 ? 796  ALA A CA    1 
ATOM   3999 C C     . ALA A 1 503 ? -7.358  104.612 40.215  1.00 42.96 ? 796  ALA A C     1 
ATOM   4000 O O     . ALA A 1 503 ? -7.710  103.554 39.691  1.00 40.29 ? 796  ALA A O     1 
ATOM   4001 C CB    . ALA A 1 503 ? -4.914  104.989 40.593  1.00 39.10 ? 796  ALA A CB    1 
ATOM   4002 N N     . GLU A 1 504 ? -8.044  105.214 41.196  1.00 44.20 ? 797  GLU A N     1 
ATOM   4003 C CA    . GLU A 1 504 ? -9.217  104.625 41.816  1.00 43.08 ? 797  GLU A CA    1 
ATOM   4004 C C     . GLU A 1 504 ? -10.370 104.561 40.815  1.00 41.04 ? 797  GLU A C     1 
ATOM   4005 O O     . GLU A 1 504 ? -11.067 103.544 40.730  1.00 35.92 ? 797  GLU A O     1 
ATOM   4006 C CB    . GLU A 1 504 ? -9.567  105.442 43.062  1.00 46.92 ? 797  GLU A CB    1 
ATOM   4007 C CG    . GLU A 1 504 ? -10.525 104.755 44.004  1.00 49.72 ? 797  GLU A CG    1 
ATOM   4008 C CD    . GLU A 1 504 ? -11.943 104.650 43.483  1.00 53.32 ? 797  GLU A CD    1 
ATOM   4009 O OE1   . GLU A 1 504 ? -12.409 105.637 42.866  1.00 57.80 ? 797  GLU A OE1   1 
ATOM   4010 O OE2   . GLU A 1 504 ? -12.572 103.586 43.701  1.00 52.19 ? 797  GLU A OE2   1 
ATOM   4011 N N     . ALA A 1 505 ? -10.566 105.651 40.060  1.00 38.67 ? 798  ALA A N     1 
ATOM   4012 C CA    . ALA A 1 505 ? -11.597 105.712 39.028  1.00 37.26 ? 798  ALA A CA    1 
ATOM   4013 C C     . ALA A 1 505 ? -11.257 104.789 37.849  1.00 34.65 ? 798  ALA A C     1 
ATOM   4014 O O     . ALA A 1 505 ? -12.126 104.134 37.268  1.00 31.22 ? 798  ALA A O     1 
ATOM   4015 C CB    . ALA A 1 505 ? -11.755 107.138 38.561  1.00 38.90 ? 798  ALA A CB    1 
ATOM   4016 N N     . VAL A 1 506 ? -9.988  104.753 37.457  1.00 35.61 ? 799  VAL A N     1 
ATOM   4017 C CA    . VAL A 1 506 ? -9.566  103.817 36.420  1.00 36.53 ? 799  VAL A CA    1 
ATOM   4018 C C     . VAL A 1 506 ? -9.948  102.390 36.842  1.00 35.19 ? 799  VAL A C     1 
ATOM   4019 O O     . VAL A 1 506 ? -10.544 101.647 36.064  1.00 35.64 ? 799  VAL A O     1 
ATOM   4020 C CB    . VAL A 1 506 ? -8.067  103.977 36.129  1.00 36.07 ? 799  VAL A CB    1 
ATOM   4021 C CG1   . VAL A 1 506 ? -7.512  102.845 35.277  1.00 38.52 ? 799  VAL A CG1   1 
ATOM   4022 C CG2   . VAL A 1 506 ? -7.798  105.320 35.461  1.00 38.49 ? 799  VAL A CG2   1 
ATOM   4023 N N     . ALA A 1 507 ? -9.656  102.041 38.103  1.00 36.60 ? 800  ALA A N     1 
ATOM   4024 C CA    . ALA A 1 507 ? -9.938  100.715 38.640  1.00 36.76 ? 800  ALA A CA    1 
ATOM   4025 C C     . ALA A 1 507 ? -11.425 100.408 38.538  1.00 37.93 ? 800  ALA A C     1 
ATOM   4026 O O     . ALA A 1 507 ? -11.822 99.318  38.109  1.00 34.38 ? 800  ALA A O     1 
ATOM   4027 C CB    . ALA A 1 507 ? -9.450  100.630 40.066  1.00 37.67 ? 800  ALA A CB    1 
ATOM   4028 N N     . ARG A 1 508 ? -12.255 101.401 38.890  1.00 41.16 ? 801  ARG A N     1 
ATOM   4029 C CA    . ARG A 1 508 ? -13.692 101.186 38.901  1.00 40.84 ? 801  ARG A CA    1 
ATOM   4030 C C     . ARG A 1 508 ? -14.191 100.985 37.474  1.00 36.61 ? 801  ARG A C     1 
ATOM   4031 O O     . ARG A 1 508 ? -14.951 100.059 37.222  1.00 33.31 ? 801  ARG A O     1 
ATOM   4032 C CB    . ARG A 1 508 ? -14.407 102.337 39.614  1.00 46.78 ? 801  ARG A CB    1 
ATOM   4033 C CG    . ARG A 1 508 ? -15.865 102.041 39.931  1.00 49.17 ? 801  ARG A CG    1 
ATOM   4034 C CD    . ARG A 1 508 ? -16.384 102.965 41.016  1.00 54.40 ? 801  ARG A CD    1 
ATOM   4035 N NE    . ARG A 1 508 ? -15.905 104.324 40.796  1.00 59.40 ? 801  ARG A NE    1 
ATOM   4036 C CZ    . ARG A 1 508 ? -15.168 105.023 41.656  1.00 63.63 ? 801  ARG A CZ    1 
ATOM   4037 N NH1   . ARG A 1 508 ? -15.120 104.674 42.931  1.00 65.80 ? 801  ARG A NH1   1 
ATOM   4038 N NH2   . ARG A 1 508 ? -14.508 106.094 41.241  1.00 66.27 ? 801  ARG A NH2   1 
ATOM   4039 N N     . LEU A 1 509 ? -13.743 101.836 36.538  1.00 36.13 ? 802  LEU A N     1 
ATOM   4040 C CA    . LEU A 1 509 ? -14.123 101.702 35.141  1.00 35.64 ? 802  LEU A CA    1 
ATOM   4041 C C     . LEU A 1 509 ? -13.681 100.347 34.581  1.00 31.59 ? 802  LEU A C     1 
ATOM   4042 O O     . LEU A 1 509 ? -14.449 99.679  33.893  1.00 30.78 ? 802  LEU A O     1 
ATOM   4043 C CB    . LEU A 1 509 ? -13.499 102.828 34.312  1.00 39.52 ? 802  LEU A CB    1 
ATOM   4044 C CG    . LEU A 1 509 ? -13.694 102.686 32.799  1.00 43.70 ? 802  LEU A CG    1 
ATOM   4045 C CD1   . LEU A 1 509 ? -14.752 103.650 32.288  1.00 46.89 ? 802  LEU A CD1   1 
ATOM   4046 C CD2   . LEU A 1 509 ? -12.387 102.866 32.045  1.00 46.65 ? 802  LEU A CD2   1 
ATOM   4047 N N     . ALA A 1 510 ? -12.421 99.973  34.821  1.00 33.66 ? 803  ALA A N     1 
ATOM   4048 C CA    . ALA A 1 510 ? -11.876 98.750  34.240  1.00 31.90 ? 803  ALA A CA    1 
ATOM   4049 C C     . ALA A 1 510 ? -12.661 97.522  34.716  1.00 31.21 ? 803  ALA A C     1 
ATOM   4050 O O     . ALA A 1 510 ? -12.975 96.638  33.922  1.00 27.95 ? 803  ALA A O     1 
ATOM   4051 C CB    . ALA A 1 510 ? -10.415 98.647  34.579  1.00 33.17 ? 803  ALA A CB    1 
ATOM   4052 N N     . LYS A 1 511 ? -12.951 97.462  36.028  1.00 31.58 ? 804  LYS A N     1 
ATOM   4053 C CA    . LYS A 1 511 ? -13.751 96.392  36.605  1.00 32.13 ? 804  LYS A CA    1 
ATOM   4054 C C     . LYS A 1 511 ? -15.056 96.237  35.836  1.00 32.94 ? 804  LYS A C     1 
ATOM   4055 O O     . LYS A 1 511 ? -15.413 95.128  35.442  1.00 30.90 ? 804  LYS A O     1 
ATOM   4056 C CB    . LYS A 1 511 ? -14.059 96.680  38.080  1.00 34.67 ? 804  LYS A CB    1 
ATOM   4057 C CG    . LYS A 1 511 ? -14.768 95.563  38.846  1.00 36.70 ? 804  LYS A CG    1 
ATOM   4058 C CD    . LYS A 1 511 ? -14.959 95.927  40.318  1.00 40.33 ? 804  LYS A CD    1 
ATOM   4059 C CE    . LYS A 1 511 ? -15.223 94.765  41.248  1.00 40.54 ? 804  LYS A CE    1 
ATOM   4060 N NZ    . LYS A 1 511 ? -16.551 94.172  41.004  1.00 46.09 ? 804  LYS A NZ    1 
ATOM   4061 N N     . GLU A 1 512 ? -15.753 97.371  35.637  1.00 36.46 ? 805  GLU A N     1 
ATOM   4062 C CA    . GLU A 1 512 ? -17.082 97.399  35.053  1.00 37.76 ? 805  GLU A CA    1 
ATOM   4063 C C     . GLU A 1 512 ? -17.036 96.916  33.607  1.00 32.49 ? 805  GLU A C     1 
ATOM   4064 O O     . GLU A 1 512 ? -17.891 96.148  33.177  1.00 32.21 ? 805  GLU A O     1 
ATOM   4065 C CB    . GLU A 1 512 ? -17.656 98.816  35.157  1.00 46.82 ? 805  GLU A CB    1 
ATOM   4066 C CG    . GLU A 1 512 ? -17.910 99.252  36.597  1.00 58.46 ? 805  GLU A CG    1 
ATOM   4067 C CD    . GLU A 1 512 ? -18.316 100.705 36.823  1.00 66.23 ? 805  GLU A CD    1 
ATOM   4068 O OE1   . GLU A 1 512 ? -18.344 101.487 35.839  1.00 68.74 ? 805  GLU A OE1   1 
ATOM   4069 O OE2   . GLU A 1 512 ? -18.611 101.055 37.991  1.00 71.57 ? 805  GLU A OE2   1 
ATOM   4070 N N     . VAL A 1 513 ? -16.057 97.399  32.839  1.00 30.26 ? 806  VAL A N     1 
ATOM   4071 C CA    . VAL A 1 513 ? -15.920 96.971  31.455  1.00 30.02 ? 806  VAL A CA    1 
ATOM   4072 C C     . VAL A 1 513 ? -15.662 95.462  31.406  1.00 28.20 ? 806  VAL A C     1 
ATOM   4073 O O     . VAL A 1 513 ? -16.303 94.744  30.636  1.00 28.14 ? 806  VAL A O     1 
ATOM   4074 C CB    . VAL A 1 513 ? -14.824 97.789  30.743  1.00 30.95 ? 806  VAL A CB    1 
ATOM   4075 C CG1   . VAL A 1 513 ? -14.443 97.211  29.388  1.00 33.13 ? 806  VAL A CG1   1 
ATOM   4076 C CG2   . VAL A 1 513 ? -15.255 99.247  30.593  1.00 31.61 ? 806  VAL A CG2   1 
ATOM   4077 N N     . MET A 1 514 ? -14.761 94.973  32.268  1.00 29.72 ? 807  MET A N     1 
ATOM   4078 C CA    . MET A 1 514 ? -14.361 93.570  32.216  1.00 30.28 ? 807  MET A CA    1 
ATOM   4079 C C     . MET A 1 514 ? -15.515 92.660  32.629  1.00 30.90 ? 807  MET A C     1 
ATOM   4080 O O     . MET A 1 514 ? -15.782 91.670  31.957  1.00 30.90 ? 807  MET A O     1 
ATOM   4081 C CB    . MET A 1 514 ? -13.143 93.321  33.105  1.00 29.79 ? 807  MET A CB    1 
ATOM   4082 C CG    . MET A 1 514 ? -11.875 93.775  32.466  1.00 29.89 ? 807  MET A CG    1 
ATOM   4083 S SD    . MET A 1 514 ? -10.503 93.857  33.607  1.00 32.04 ? 807  MET A SD    1 
ATOM   4084 C CE    . MET A 1 514 ? -9.950  92.151  33.663  1.00 33.48 ? 807  MET A CE    1 
ATOM   4085 N N     . GLU A 1 515 ? -16.221 93.007  33.717  1.00 33.08 ? 808  GLU A N     1 
ATOM   4086 C CA    . GLU A 1 515 ? -17.313 92.173  34.206  1.00 35.20 ? 808  GLU A CA    1 
ATOM   4087 C C     . GLU A 1 515 ? -18.487 92.186  33.226  1.00 33.52 ? 808  GLU A C     1 
ATOM   4088 O O     . GLU A 1 515 ? -19.220 91.199  33.113  1.00 33.79 ? 808  GLU A O     1 
ATOM   4089 C CB    . GLU A 1 515 ? -17.757 92.614  35.611  1.00 36.82 ? 808  GLU A CB    1 
ATOM   4090 C CG    . GLU A 1 515 ? -16.778 92.232  36.708  1.00 38.31 ? 808  GLU A CG    1 
ATOM   4091 C CD    . GLU A 1 515 ? -17.218 92.569  38.125  1.00 39.09 ? 808  GLU A CD    1 
ATOM   4092 O OE1   . GLU A 1 515 ? -18.192 93.329  38.244  1.00 37.93 ? 808  GLU A OE1   1 
ATOM   4093 O OE2   . GLU A 1 515 ? -16.597 92.052  39.110  1.00 34.33 ? 808  GLU A OE2   1 
ATOM   4094 N N     . GLY A 1 516 ? -18.667 93.304  32.508  1.00 34.35 ? 809  GLY A N     1 
ATOM   4095 C CA    . GLY A 1 516 ? -19.786 93.443  31.583  1.00 33.58 ? 809  GLY A CA    1 
ATOM   4096 C C     . GLY A 1 516 ? -19.443 93.112  30.129  1.00 33.92 ? 809  GLY A C     1 
ATOM   4097 O O     . GLY A 1 516 ? -20.267 93.352  29.245  1.00 31.61 ? 809  GLY A O     1 
ATOM   4098 N N     . VAL A 1 517 ? -18.268 92.496  29.890  1.00 33.34 ? 810  VAL A N     1 
ATOM   4099 C CA    . VAL A 1 517 ? -17.697 92.342  28.553  1.00 31.44 ? 810  VAL A CA    1 
ATOM   4100 C C     . VAL A 1 517 ? -18.695 91.663  27.627  1.00 31.25 ? 810  VAL A C     1 
ATOM   4101 O O     . VAL A 1 517 ? -18.833 92.044  26.467  1.00 35.88 ? 810  VAL A O     1 
ATOM   4102 C CB    . VAL A 1 517 ? -16.352 91.570  28.575  1.00 32.48 ? 810  VAL A CB    1 
ATOM   4103 C CG1   . VAL A 1 517 ? -16.512 90.103  28.975  1.00 29.36 ? 810  VAL A CG1   1 
ATOM   4104 C CG2   . VAL A 1 517 ? -15.626 91.675  27.244  1.00 33.00 ? 810  VAL A CG2   1 
ATOM   4105 N N     . TYR A 1 518 ? -19.383 90.645  28.139  1.00 29.98 ? 811  TYR A N     1 
ATOM   4106 C CA    . TYR A 1 518 ? -20.258 89.819  27.327  1.00 30.69 ? 811  TYR A CA    1 
ATOM   4107 C C     . TYR A 1 518 ? -21.197 89.077  28.269  1.00 33.03 ? 811  TYR A C     1 
ATOM   4108 O O     . TYR A 1 518 ? -20.755 88.610  29.310  1.00 34.18 ? 811  TYR A O     1 
ATOM   4109 C CB    . TYR A 1 518 ? -19.450 88.820  26.487  1.00 32.34 ? 811  TYR A CB    1 
ATOM   4110 C CG    . TYR A 1 518 ? -20.254 88.077  25.455  1.00 33.53 ? 811  TYR A CG    1 
ATOM   4111 C CD1   . TYR A 1 518 ? -20.480 88.621  24.197  1.00 39.23 ? 811  TYR A CD1   1 
ATOM   4112 C CD2   . TYR A 1 518 ? -20.855 86.867  25.752  1.00 36.39 ? 811  TYR A CD2   1 
ATOM   4113 C CE1   . TYR A 1 518 ? -21.267 87.972  23.256  1.00 40.08 ? 811  TYR A CE1   1 
ATOM   4114 C CE2   . TYR A 1 518 ? -21.621 86.190  24.816  1.00 37.71 ? 811  TYR A CE2   1 
ATOM   4115 C CZ    . TYR A 1 518 ? -21.836 86.754  23.572  1.00 39.84 ? 811  TYR A CZ    1 
ATOM   4116 O OH    . TYR A 1 518 ? -22.584 86.088  22.648  1.00 46.96 ? 811  TYR A OH    1 
ATOM   4117 N N     . PRO A 1 519 ? -22.507 88.961  27.956  1.00 36.69 ? 812  PRO A N     1 
ATOM   4118 C CA    . PRO A 1 519 ? -23.446 88.258  28.833  1.00 37.10 ? 812  PRO A CA    1 
ATOM   4119 C C     . PRO A 1 519 ? -23.270 86.743  28.813  1.00 34.22 ? 812  PRO A C     1 
ATOM   4120 O O     . PRO A 1 519 ? -23.334 86.134  27.753  1.00 41.80 ? 812  PRO A O     1 
ATOM   4121 C CB    . PRO A 1 519 ? -24.834 88.640  28.283  1.00 36.93 ? 812  PRO A CB    1 
ATOM   4122 C CG    . PRO A 1 519 ? -24.587 88.992  26.830  1.00 37.35 ? 812  PRO A CG    1 
ATOM   4123 C CD    . PRO A 1 519 ? -23.168 89.535  26.772  1.00 37.24 ? 812  PRO A CD    1 
ATOM   4124 N N     . LEU A 1 520 ? -23.046 86.153  29.995  1.00 34.10 ? 813  LEU A N     1 
ATOM   4125 C CA    . LEU A 1 520 ? -23.039 84.708  30.163  1.00 34.08 ? 813  LEU A CA    1 
ATOM   4126 C C     . LEU A 1 520 ? -24.122 84.309  31.159  1.00 34.95 ? 813  LEU A C     1 
ATOM   4127 O O     . LEU A 1 520 ? -24.680 85.165  31.843  1.00 36.03 ? 813  LEU A O     1 
ATOM   4128 C CB    . LEU A 1 520 ? -21.672 84.270  30.698  1.00 35.17 ? 813  LEU A CB    1 
ATOM   4129 C CG    . LEU A 1 520 ? -20.469 84.727  29.878  1.00 37.07 ? 813  LEU A CG    1 
ATOM   4130 C CD1   . LEU A 1 520 ? -19.164 84.402  30.599  1.00 37.35 ? 813  LEU A CD1   1 
ATOM   4131 C CD2   . LEU A 1 520 ? -20.507 84.091  28.504  1.00 34.11 ? 813  LEU A CD2   1 
ATOM   4132 N N     . ALA A 1 521 ? -24.311 82.993  31.303  1.00 34.84 ? 814  ALA A N     1 
ATOM   4133 C CA    . ALA A 1 521 ? -25.257 82.409  32.244  1.00 35.01 ? 814  ALA A CA    1 
ATOM   4134 C C     . ALA A 1 521 ? -24.841 82.668  33.691  1.00 32.54 ? 814  ALA A C     1 
ATOM   4135 O O     . ALA A 1 521 ? -25.601 82.406  34.620  1.00 32.60 ? 814  ALA A O     1 
ATOM   4136 C CB    . ALA A 1 521 ? -25.381 80.932  31.972  1.00 33.62 ? 814  ALA A CB    1 
ATOM   4137 N N     . VAL A 1 522 ? -23.615 83.159  33.880  1.00 30.42 ? 815  VAL A N     1 
ATOM   4138 C CA    . VAL A 1 522 ? -23.086 83.427  35.198  1.00 30.50 ? 815  VAL A CA    1 
ATOM   4139 C C     . VAL A 1 522 ? -22.453 84.810  35.171  1.00 29.58 ? 815  VAL A C     1 
ATOM   4140 O O     . VAL A 1 522 ? -22.021 85.277  34.118  1.00 29.35 ? 815  VAL A O     1 
ATOM   4141 C CB    . VAL A 1 522 ? -22.061 82.351  35.623  1.00 31.76 ? 815  VAL A CB    1 
ATOM   4142 C CG1   . VAL A 1 522 ? -22.701 80.981  35.759  1.00 31.84 ? 815  VAL A CG1   1 
ATOM   4143 C CG2   . VAL A 1 522 ? -20.862 82.284  34.684  1.00 31.27 ? 815  VAL A CG2   1 
ATOM   4144 N N     . PRO A 1 523 ? -22.329 85.486  36.332  1.00 30.34 ? 816  PRO A N     1 
ATOM   4145 C CA    . PRO A 1 523 ? -21.523 86.698  36.411  1.00 31.00 ? 816  PRO A CA    1 
ATOM   4146 C C     . PRO A 1 523 ? -20.051 86.373  36.169  1.00 32.28 ? 816  PRO A C     1 
ATOM   4147 O O     . PRO A 1 523 ? -19.565 85.319  36.581  1.00 33.92 ? 816  PRO A O     1 
ATOM   4148 C CB    . PRO A 1 523 ? -21.708 87.239  37.837  1.00 31.81 ? 816  PRO A CB    1 
ATOM   4149 C CG    . PRO A 1 523 ? -22.603 86.239  38.564  1.00 31.35 ? 816  PRO A CG    1 
ATOM   4150 C CD    . PRO A 1 523 ? -22.978 85.138  37.598  1.00 31.35 ? 816  PRO A CD    1 
ATOM   4151 N N     . LEU A 1 524 ? -19.358 87.302  35.510  1.00 32.59 ? 817  LEU A N     1 
ATOM   4152 C CA    . LEU A 1 524 ? -17.908 87.399  35.586  1.00 35.04 ? 817  LEU A CA    1 
ATOM   4153 C C     . LEU A 1 524 ? -17.550 88.245  36.800  1.00 36.90 ? 817  LEU A C     1 
ATOM   4154 O O     . LEU A 1 524 ? -18.136 89.307  37.010  1.00 40.99 ? 817  LEU A O     1 
ATOM   4155 C CB    . LEU A 1 524 ? -17.381 88.018  34.290  1.00 34.20 ? 817  LEU A CB    1 
ATOM   4156 C CG    . LEU A 1 524 ? -17.553 87.146  33.045  1.00 36.40 ? 817  LEU A CG    1 
ATOM   4157 C CD1   . LEU A 1 524 ? -17.055 87.856  31.797  1.00 36.47 ? 817  LEU A CD1   1 
ATOM   4158 C CD2   . LEU A 1 524 ? -16.843 85.805  33.201  1.00 35.69 ? 817  LEU A CD2   1 
ATOM   4159 N N     . GLU A 1 525 ? -16.633 87.739  37.633  1.00 35.98 ? 818  GLU A N     1 
ATOM   4160 C CA    . GLU A 1 525 ? -16.170 88.486  38.787  1.00 36.59 ? 818  GLU A CA    1 
ATOM   4161 C C     . GLU A 1 525 ? -14.715 88.894  38.581  1.00 33.57 ? 818  GLU A C     1 
ATOM   4162 O O     . GLU A 1 525 ? -13.866 88.084  38.218  1.00 33.08 ? 818  GLU A O     1 
ATOM   4163 C CB    . GLU A 1 525 ? -16.391 87.685  40.069  1.00 42.05 ? 818  GLU A CB    1 
ATOM   4164 C CG    . GLU A 1 525 ? -17.874 87.450  40.328  1.00 48.14 ? 818  GLU A CG    1 
ATOM   4165 C CD    . GLU A 1 525 ? -18.298 87.250  41.775  1.00 56.08 ? 818  GLU A CD    1 
ATOM   4166 O OE1   . GLU A 1 525 ? -19.536 87.253  42.022  1.00 57.73 ? 818  GLU A OE1   1 
ATOM   4167 O OE2   . GLU A 1 525 ? -17.404 87.080  42.649  1.00 54.08 ? 818  GLU A OE2   1 
ATOM   4168 N N     . VAL A 1 526 ? -14.448 90.172  38.829  1.00 31.58 ? 819  VAL A N     1 
ATOM   4169 C CA    . VAL A 1 526 ? -13.119 90.723  38.653  1.00 33.40 ? 819  VAL A CA    1 
ATOM   4170 C C     . VAL A 1 526 ? -12.648 91.270  39.995  1.00 33.37 ? 819  VAL A C     1 
ATOM   4171 O O     . VAL A 1 526 ? -13.331 92.091  40.601  1.00 30.56 ? 819  VAL A O     1 
ATOM   4172 C CB    . VAL A 1 526 ? -13.126 91.782  37.535  1.00 32.54 ? 819  VAL A CB    1 
ATOM   4173 C CG1   . VAL A 1 526 ? -11.792 92.487  37.384  1.00 32.65 ? 819  VAL A CG1   1 
ATOM   4174 C CG2   . VAL A 1 526 ? -13.536 91.157  36.214  1.00 33.27 ? 819  VAL A CG2   1 
ATOM   4175 N N     . GLU A 1 527 ? -11.504 90.756  40.463  1.00 31.86 ? 820  GLU A N     1 
ATOM   4176 C CA    . GLU A 1 527 ? -10.803 91.309  41.605  1.00 33.66 ? 820  GLU A CA    1 
ATOM   4177 C C     . GLU A 1 527 ? -9.868  92.416  41.127  1.00 34.60 ? 820  GLU A C     1 
ATOM   4178 O O     . GLU A 1 527 ? -9.290  92.327  40.049  1.00 31.37 ? 820  GLU A O     1 
ATOM   4179 C CB    . GLU A 1 527 ? -10.020 90.219  42.337  1.00 36.85 ? 820  GLU A CB    1 
ATOM   4180 C CG    . GLU A 1 527 ? -10.917 89.217  43.039  1.00 40.54 ? 820  GLU A CG    1 
ATOM   4181 C CD    . GLU A 1 527 ? -10.192 88.228  43.937  1.00 45.18 ? 820  GLU A CD    1 
ATOM   4182 O OE1   . GLU A 1 527 ? -8.940  88.117  43.830  1.00 47.47 ? 820  GLU A OE1   1 
ATOM   4183 O OE2   . GLU A 1 527 ? -10.878 87.597  44.763  1.00 52.79 ? 820  GLU A OE2   1 
ATOM   4184 N N     . VAL A 1 528 ? -9.725  93.449  41.955  1.00 32.39 ? 821  VAL A N     1 
ATOM   4185 C CA    . VAL A 1 528 ? -9.012  94.657  41.580  1.00 36.56 ? 821  VAL A CA    1 
ATOM   4186 C C     . VAL A 1 528 ? -8.206  95.135  42.779  1.00 36.00 ? 821  VAL A C     1 
ATOM   4187 O O     . VAL A 1 528 ? -8.747  95.256  43.880  1.00 39.45 ? 821  VAL A O     1 
ATOM   4188 C CB    . VAL A 1 528 ? -9.961  95.792  41.158  1.00 40.87 ? 821  VAL A CB    1 
ATOM   4189 C CG1   . VAL A 1 528 ? -9.192  96.924  40.479  1.00 41.51 ? 821  VAL A CG1   1 
ATOM   4190 C CG2   . VAL A 1 528 ? -11.096 95.290  40.292  1.00 44.86 ? 821  VAL A CG2   1 
ATOM   4191 N N     . GLY A 1 529 ? -6.934  95.454  42.537  1.00 35.45 ? 822  GLY A N     1 
ATOM   4192 C CA    . GLY A 1 529 ? -6.095  96.070  43.546  1.00 34.98 ? 822  GLY A CA    1 
ATOM   4193 C C     . GLY A 1 529 ? -5.248  97.183  42.946  1.00 38.86 ? 822  GLY A C     1 
ATOM   4194 O O     . GLY A 1 529 ? -4.959  97.176  41.743  1.00 34.30 ? 822  GLY A O     1 
ATOM   4195 N N     . ILE A 1 530 ? -4.843  98.115  43.816  1.00 38.67 ? 823  ILE A N     1 
ATOM   4196 C CA    . ILE A 1 530 ? -4.056  99.267  43.413  1.00 37.97 ? 823  ILE A CA    1 
ATOM   4197 C C     . ILE A 1 530 ? -2.799  99.328  44.263  1.00 37.59 ? 823  ILE A C     1 
ATOM   4198 O O     . ILE A 1 530 ? -2.858  99.159  45.479  1.00 39.27 ? 823  ILE A O     1 
ATOM   4199 C CB    . ILE A 1 530 ? -4.885  100.558 43.531  1.00 38.24 ? 823  ILE A CB    1 
ATOM   4200 C CG1   . ILE A 1 530 ? -6.180  100.446 42.726  1.00 36.53 ? 823  ILE A CG1   1 
ATOM   4201 C CG2   . ILE A 1 530 ? -4.025  101.755 43.138  1.00 38.70 ? 823  ILE A CG2   1 
ATOM   4202 C CD1   . ILE A 1 530 ? -7.125  101.633 42.839  1.00 38.31 ? 823  ILE A CD1   1 
ATOM   4203 N N     . GLY A 1 531 ? -1.659  99.572  43.616  1.00 36.74 ? 824  GLY A N     1 
ATOM   4204 C CA    . GLY A 1 531 ? -0.402  99.631  44.339  1.00 36.62 ? 824  GLY A CA    1 
ATOM   4205 C C     . GLY A 1 531 ? 0.694   100.329 43.550  1.00 37.90 ? 824  GLY A C     1 
ATOM   4206 O O     . GLY A 1 531 ? 0.513   100.621 42.371  1.00 39.09 ? 824  GLY A O     1 
ATOM   4207 N N     . GLU A 1 532 ? 1.815   100.583 44.237  1.00 38.83 ? 825  GLU A N     1 
ATOM   4208 C CA    . GLU A 1 532 ? 3.009   101.169 43.646  1.00 39.57 ? 825  GLU A CA    1 
ATOM   4209 C C     . GLU A 1 532 ? 3.860   100.094 42.964  1.00 38.57 ? 825  GLU A C     1 
ATOM   4210 O O     . GLU A 1 532 ? 4.742   100.413 42.173  1.00 39.31 ? 825  GLU A O     1 
ATOM   4211 C CB    . GLU A 1 532 ? 3.862   101.848 44.722  1.00 38.07 ? 825  GLU A CB    1 
ATOM   4212 C CG    . GLU A 1 532 ? 3.126   102.927 45.499  1.00 40.88 ? 825  GLU A CG    1 
ATOM   4213 C CD    . GLU A 1 532 ? 4.003   103.675 46.492  1.00 45.69 ? 825  GLU A CD    1 
ATOM   4214 O OE1   . GLU A 1 532 ? 5.212   103.360 46.570  1.00 50.30 ? 825  GLU A OE1   1 
ATOM   4215 O OE2   . GLU A 1 532 ? 3.478   104.567 47.182  1.00 45.67 ? 825  GLU A OE2   1 
ATOM   4216 N N     . ASP A 1 533 ? 3.633   98.825  43.318  1.00 36.86 ? 826  ASP A N     1 
ATOM   4217 C CA    . ASP A 1 533 ? 4.303   97.720  42.656  1.00 37.49 ? 826  ASP A CA    1 
ATOM   4218 C C     . ASP A 1 533 ? 3.267   96.629  42.391  1.00 37.34 ? 826  ASP A C     1 
ATOM   4219 O O     . ASP A 1 533 ? 2.140   96.697  42.888  1.00 34.73 ? 826  ASP A O     1 
ATOM   4220 C CB    . ASP A 1 533 ? 5.508   97.245  43.469  1.00 40.87 ? 826  ASP A CB    1 
ATOM   4221 C CG    . ASP A 1 533 ? 5.120   96.551  44.764  1.00 43.61 ? 826  ASP A CG    1 
ATOM   4222 O OD1   . ASP A 1 533 ? 4.796   95.349  44.706  1.00 42.45 ? 826  ASP A OD1   1 
ATOM   4223 O OD2   . ASP A 1 533 ? 5.077   97.233  45.805  1.00 42.04 ? 826  ASP A OD2   1 
ATOM   4224 N N     . TRP A 1 534 ? 3.665   95.627  41.594  1.00 35.36 ? 827  TRP A N     1 
ATOM   4225 C CA    . TRP A 1 534 ? 2.736   94.630  41.085  1.00 32.49 ? 827  TRP A CA    1 
ATOM   4226 C C     . TRP A 1 534 ? 2.253   93.713  42.211  1.00 32.50 ? 827  TRP A C     1 
ATOM   4227 O O     . TRP A 1 534 ? 1.079   93.353  42.244  1.00 35.19 ? 827  TRP A O     1 
ATOM   4228 C CB    . TRP A 1 534 ? 3.404   93.848  39.952  1.00 31.53 ? 827  TRP A CB    1 
ATOM   4229 C CG    . TRP A 1 534 ? 2.519   92.929  39.160  1.00 30.48 ? 827  TRP A CG    1 
ATOM   4230 C CD1   . TRP A 1 534 ? 1.183   92.685  39.298  1.00 30.72 ? 827  TRP A CD1   1 
ATOM   4231 C CD2   . TRP A 1 534 ? 2.954   92.122  38.055  1.00 30.91 ? 827  TRP A CD2   1 
ATOM   4232 N NE1   . TRP A 1 534 ? 0.757   91.771  38.367  1.00 32.46 ? 827  TRP A NE1   1 
ATOM   4233 C CE2   . TRP A 1 534 ? 1.824   91.406  37.588  1.00 32.09 ? 827  TRP A CE2   1 
ATOM   4234 C CE3   . TRP A 1 534 ? 4.186   91.945  37.420  1.00 32.58 ? 827  TRP A CE3   1 
ATOM   4235 C CZ2   . TRP A 1 534 ? 1.898   90.525  36.513  1.00 32.00 ? 827  TRP A CZ2   1 
ATOM   4236 C CZ3   . TRP A 1 534 ? 4.260   91.071  36.358  1.00 34.04 ? 827  TRP A CZ3   1 
ATOM   4237 C CH2   . TRP A 1 534 ? 3.131   90.368  35.919  1.00 35.41 ? 827  TRP A CH2   1 
ATOM   4238 N N     . LEU A 1 535 ? 3.150   93.370  43.141  1.00 33.20 ? 828  LEU A N     1 
ATOM   4239 C CA    . LEU A 1 535 ? 2.803   92.501  44.253  1.00 35.92 ? 828  LEU A CA    1 
ATOM   4240 C C     . LEU A 1 535 ? 1.870   93.202  45.241  1.00 35.63 ? 828  LEU A C     1 
ATOM   4241 O O     . LEU A 1 535 ? 0.898   92.606  45.700  1.00 35.44 ? 828  LEU A O     1 
ATOM   4242 C CB    . LEU A 1 535 ? 4.068   92.048  44.981  1.00 35.80 ? 828  LEU A CB    1 
ATOM   4243 C CG    . LEU A 1 535 ? 3.789   91.133  46.174  1.00 37.87 ? 828  LEU A CG    1 
ATOM   4244 C CD1   . LEU A 1 535 ? 3.403   89.742  45.697  1.00 36.81 ? 828  LEU A CD1   1 
ATOM   4245 C CD2   . LEU A 1 535 ? 4.965   91.087  47.125  1.00 37.91 ? 828  LEU A CD2   1 
ATOM   4246 N N     . SER A 1 536 ? 2.193   94.447  45.602  1.00 34.88 ? 829  SER A N     1 
ATOM   4247 C CA    . SER A 1 536 ? 1.328   95.240  46.463  1.00 35.41 ? 829  SER A CA    1 
ATOM   4248 C C     . SER A 1 536 ? -0.069  95.350  45.870  1.00 34.69 ? 829  SER A C     1 
ATOM   4249 O O     . SER A 1 536 ? -1.051  95.261  46.596  1.00 34.91 ? 829  SER A O     1 
ATOM   4250 C CB    . SER A 1 536 ? 1.907   96.604  46.712  1.00 36.52 ? 829  SER A CB    1 
ATOM   4251 O OG    . SER A 1 536 ? 3.159   96.470  47.345  1.00 35.85 ? 829  SER A OG    1 
ATOM   4252 N N     . ALA A 1 537 ? -0.151  95.536  44.549  1.00 36.72 ? 830  ALA A N     1 
ATOM   4253 C CA    . ALA A 1 537 ? -1.426  95.705  43.867  1.00 34.06 ? 830  ALA A CA    1 
ATOM   4254 C C     . ALA A 1 537 ? -2.269  94.426  43.958  1.00 36.96 ? 830  ALA A C     1 
ATOM   4255 O O     . ALA A 1 537 ? -3.480  94.478  44.176  1.00 34.96 ? 830  ALA A O     1 
ATOM   4256 C CB    . ALA A 1 537 ? -1.169  96.119  42.438  1.00 35.30 ? 830  ALA A CB    1 
ATOM   4257 N N     . LYS A 1 538 ? -1.621  93.264  43.837  1.00 37.02 ? 831  LYS A N     1 
ATOM   4258 C CA    . LYS A 1 538 ? -2.329  91.994  43.917  1.00 39.51 ? 831  LYS A CA    1 
ATOM   4259 C C     . LYS A 1 538 ? -2.739  91.723  45.365  1.00 36.79 ? 831  LYS A C     1 
ATOM   4260 O O     . LYS A 1 538 ? -3.858  91.292  45.607  1.00 34.64 ? 831  LYS A O     1 
ATOM   4261 C CB    . LYS A 1 538 ? -1.450  90.878  43.344  1.00 41.29 ? 831  LYS A CB    1 
ATOM   4262 C CG    . LYS A 1 538 ? -1.073  91.049  41.878  1.00 42.66 ? 831  LYS A CG    1 
ATOM   4263 C CD    . LYS A 1 538 ? -1.921  90.244  40.929  1.00 47.35 ? 831  LYS A CD    1 
ATOM   4264 C CE    . LYS A 1 538 ? -1.573  88.773  40.915  1.00 48.98 ? 831  LYS A CE    1 
ATOM   4265 N NZ    . LYS A 1 538 ? -2.674  87.959  40.341  1.00 52.65 ? 831  LYS A NZ    1 
ATOM   4266 N N     . GLU A 1 539 ? -1.843  92.015  46.316  1.00 39.18 ? 832  GLU A N     1 
ATOM   4267 C CA    . GLU A 1 539 ? -2.137  91.877  47.737  1.00 40.32 ? 832  GLU A CA    1 
ATOM   4268 C C     . GLU A 1 539 ? -3.346  92.741  48.101  1.00 42.34 ? 832  GLU A C     1 
ATOM   4269 O O     . GLU A 1 539 ? -4.257  92.265  48.790  1.00 43.43 ? 832  GLU A O     1 
ATOM   4270 C CB    . GLU A 1 539 ? -0.899  92.212  48.574  1.00 42.26 ? 832  GLU A CB    1 
ATOM   4271 C CG    . GLU A 1 539 ? 0.120   91.080  48.630  1.00 45.45 ? 832  GLU A CG    1 
ATOM   4272 C CD    . GLU A 1 539 ? 1.465   91.406  49.266  1.00 48.17 ? 832  GLU A CD    1 
ATOM   4273 O OE1   . GLU A 1 539 ? 1.735   92.598  49.553  1.00 51.93 ? 832  GLU A OE1   1 
ATOM   4274 O OE2   . GLU A 1 539 ? 2.249   90.465  49.481  1.00 50.22 ? 832  GLU A OE2   1 
ATOM   4275 N N     . ALA A 1 540 ? -3.362  93.991  47.604  1.00 36.23 ? 833  ALA A N     1 
ATOM   4276 C CA    . ALA A 1 540 ? -4.474  94.911  47.805  1.00 36.30 ? 833  ALA A CA    1 
ATOM   4277 C C     . ALA A 1 540 ? -5.779  94.327  47.258  1.00 36.63 ? 833  ALA A C     1 
ATOM   4278 O O     . ALA A 1 540 ? -6.836  94.512  47.851  1.00 33.85 ? 833  ALA A O     1 
ATOM   4279 C CB    . ALA A 1 540 ? -4.158  96.254  47.177  1.00 36.99 ? 833  ALA A CB    1 
ATOM   4280 N N     . ALA A 1 541 ? -5.729  93.619  46.122  1.00 35.84 ? 834  ALA A N     1 
ATOM   4281 C CA    . ALA A 1 541 ? -6.938  93.023  45.559  1.00 32.69 ? 834  ALA A CA    1 
ATOM   4282 C C     . ALA A 1 541 ? -7.574  92.035  46.537  1.00 33.10 ? 834  ALA A C     1 
ATOM   4283 O O     . ALA A 1 541 ? -8.800  92.002  46.657  1.00 37.47 ? 834  ALA A O     1 
ATOM   4284 C CB    . ALA A 1 541 ? -6.649  92.355  44.225  1.00 33.04 ? 834  ALA A CB    1 
ATOM   4285 N N     . LYS A 1 542 ? -6.755  91.222  47.222  1.00 36.81 ? 835  LYS A N     1 
ATOM   4286 C CA    . LYS A 1 542 ? -7.278  90.278  48.206  1.00 38.41 ? 835  LYS A CA    1 
ATOM   4287 C C     . LYS A 1 542 ? -7.864  91.016  49.410  1.00 37.43 ? 835  LYS A C     1 
ATOM   4288 O O     . LYS A 1 542 ? -8.951  90.667  49.870  1.00 40.83 ? 835  LYS A O     1 
ATOM   4289 C CB    . LYS A 1 542 ? -6.196  89.300  48.676  1.00 39.46 ? 835  LYS A CB    1 
ATOM   4290 C CG    . LYS A 1 542 ? -5.682  88.347  47.606  1.00 44.74 ? 835  LYS A CG    1 
ATOM   4291 C CD    . LYS A 1 542 ? -6.795  87.572  46.903  1.00 44.48 ? 835  LYS A CD    1 
ATOM   4292 C CE    . LYS A 1 542 ? -6.286  86.689  45.788  1.00 45.44 ? 835  LYS A CE    1 
ATOM   4293 N NZ    . LYS A 1 542 ? -7.408  86.153  44.990  1.00 47.12 ? 835  LYS A NZ    1 
ATOM   4294 N N     . LEU A 1 543 ? -7.162  92.039  49.916  1.00 38.24 ? 836  LEU A N     1 
ATOM   4295 C CA    . LEU A 1 543 ? -7.622  92.760  51.101  1.00 40.24 ? 836  LEU A CA    1 
ATOM   4296 C C     . LEU A 1 543 ? -8.975  93.414  50.830  1.00 41.21 ? 836  LEU A C     1 
ATOM   4297 O O     . LEU A 1 543 ? -9.821  93.479  51.722  1.00 47.57 ? 836  LEU A O     1 
ATOM   4298 C CB    . LEU A 1 543 ? -6.578  93.807  51.506  1.00 42.71 ? 836  LEU A CB    1 
ATOM   4299 C CG    . LEU A 1 543 ? -5.240  93.269  52.014  1.00 42.79 ? 836  LEU A CG    1 
ATOM   4300 C CD1   . LEU A 1 543 ? -4.269  94.408  52.289  1.00 44.51 ? 836  LEU A CD1   1 
ATOM   4301 C CD2   . LEU A 1 543 ? -5.420  92.418  53.264  1.00 46.45 ? 836  LEU A CD2   1 
ATOM   4302 N N     . ALA A 1 544 ? -9.164  93.909  49.600  1.00 42.67 ? 837  ALA A N     1 
ATOM   4303 C CA    . ALA A 1 544 ? -10.403 94.549  49.189  1.00 46.35 ? 837  ALA A CA    1 
ATOM   4304 C C     . ALA A 1 544 ? -11.513 93.524  48.954  1.00 46.58 ? 837  ALA A C     1 
ATOM   4305 O O     . ALA A 1 544 ? -12.681 93.868  49.096  1.00 42.07 ? 837  ALA A O     1 
ATOM   4306 C CB    . ALA A 1 544 ? -10.175 95.362  47.941  1.00 49.60 ? 837  ALA A CB    1 
ATOM   4307 N N     . ALA A 1 545 ? -11.150 92.288  48.575  1.00 48.12 ? 838  ALA A N     1 
ATOM   4308 C CA    . ALA A 1 545 ? -12.117 91.269  48.181  1.00 49.69 ? 838  ALA A CA    1 
ATOM   4309 C C     . ALA A 1 545 ? -13.073 90.958  49.333  1.00 49.67 ? 838  ALA A C     1 
ATOM   4310 O O     . ALA A 1 545 ? -14.255 90.727  49.109  1.00 49.13 ? 838  ALA A O     1 
ATOM   4311 C CB    . ALA A 1 545 ? -11.402 90.020  47.715  1.00 49.50 ? 838  ALA A CB    1 
ATOM   4312 N N     . ALA A 1 546 ? -12.543 90.952  50.558  1.00 56.60 ? 839  ALA A N     1 
ATOM   4313 C CA    . ALA A 1 546 ? -13.340 90.867  51.772  1.00 65.31 ? 839  ALA A CA    1 
ATOM   4314 C C     . ALA A 1 546 ? -14.619 91.709  51.807  1.00 67.16 ? 839  ALA A C     1 
ATOM   4315 O O     . ALA A 1 546 ? -15.713 91.165  51.951  1.00 70.47 ? 839  ALA A O     1 
ATOM   4316 C CB    . ALA A 1 546 ? -12.491 91.307  52.942  1.00 68.92 ? 839  ALA A CB    1 
ATOM   4317 N N     . LEU A 1 547 ? -14.475 93.032  51.654  1.00 66.89 ? 840  LEU A N     1 
ATOM   4318 C CA    . LEU A 1 547 ? -15.601 93.954  51.565  1.00 70.20 ? 840  LEU A CA    1 
ATOM   4319 C C     . LEU A 1 547 ? -16.406 93.695  50.294  1.00 73.74 ? 840  LEU A C     1 
ATOM   4320 O O     . LEU A 1 547 ? -17.627 93.577  50.343  1.00 82.08 ? 840  LEU A O     1 
ATOM   4321 C CB    . LEU A 1 547 ? -15.070 95.393  51.532  1.00 69.89 ? 840  LEU A CB    1 
ATOM   4322 C CG    . LEU A 1 547 ? -14.399 95.910  52.800  1.00 67.01 ? 840  LEU A CG    1 
ATOM   4323 C CD1   . LEU A 1 547 ? -13.860 97.314  52.574  1.00 65.38 ? 840  LEU A CD1   1 
ATOM   4324 C CD2   . LEU A 1 547 ? -15.369 95.889  53.970  1.00 67.79 ? 840  LEU A CD2   1 
ATOM   4325 N N     . GLU A 1 548 ? -15.695 93.655  49.159  1.00 80.02 ? 841  GLU A N     1 
ATOM   4326 C CA    . GLU A 1 548 ? -16.286 93.549  47.833  1.00 78.87 ? 841  GLU A CA    1 
ATOM   4327 C C     . GLU A 1 548 ? -16.766 92.111  47.600  1.00 72.44 ? 841  GLU A C     1 
ATOM   4328 O O     . GLU A 1 548 ? -17.895 91.814  48.037  1.00 74.66 ? 841  GLU A O     1 
ATOM   4329 C CB    . GLU A 1 548 ? -15.261 93.979  46.777  1.00 81.96 ? 841  GLU A CB    1 
ATOM   4330 C CG    . GLU A 1 548 ? -15.197 95.483  46.556  1.00 82.75 ? 841  GLU A CG    1 
ATOM   4331 C CD    . GLU A 1 548 ? -16.158 96.011  45.501  1.00 86.29 ? 841  GLU A CD    1 
ATOM   4332 O OE1   . GLU A 1 548 ? -16.563 95.227  44.617  1.00 82.91 ? 841  GLU A OE1   1 
ATOM   4333 O OE2   . GLU A 1 548 ? -16.509 97.203  45.571  1.00 92.73 ? 841  GLU A OE2   1 
ATOM   4334 P P     . DA  B 2 1   ? -3.877  73.796  43.591  1.00 84.97 ? 202  DA  B P     1 
ATOM   4335 O OP1   . DA  B 2 1   ? -2.770  74.455  42.772  1.00 80.69 ? 202  DA  B OP1   1 
ATOM   4336 O OP2   . DA  B 2 1   ? -4.330  74.648  44.774  1.00 71.60 ? 202  DA  B OP2   1 
ATOM   4337 O "O5'" . DA  B 2 1   ? -5.151  73.517  42.588  1.00 50.10 ? 202  DA  B "O5'" 1 
ATOM   4338 C "C5'" . DA  B 2 1   ? -5.690  72.165  42.477  1.00 42.10 ? 202  DA  B "C5'" 1 
ATOM   4339 C "C4'" . DA  B 2 1   ? -5.009  71.395  41.364  1.00 38.84 ? 202  DA  B "C4'" 1 
ATOM   4340 O "O4'" . DA  B 2 1   ? -5.508  71.795  40.065  1.00 34.30 ? 202  DA  B "O4'" 1 
ATOM   4341 C "C3'" . DA  B 2 1   ? -3.492  71.541  41.292  1.00 35.14 ? 202  DA  B "C3'" 1 
ATOM   4342 O "O3'" . DA  B 2 1   ? -3.028  70.253  40.919  1.00 31.81 ? 202  DA  B "O3'" 1 
ATOM   4343 C "C2'" . DA  B 2 1   ? -3.297  72.617  40.215  1.00 34.74 ? 202  DA  B "C2'" 1 
ATOM   4344 C "C1'" . DA  B 2 1   ? -4.449  72.330  39.265  1.00 33.71 ? 202  DA  B "C1'" 1 
ATOM   4345 N N9    . DA  B 2 1   ? -4.992  73.478  38.526  1.00 31.18 ? 202  DA  B N9    1 
ATOM   4346 C C8    . DA  B 2 1   ? -5.199  73.494  37.170  1.00 29.20 ? 202  DA  B C8    1 
ATOM   4347 N N7    . DA  B 2 1   ? -5.735  74.610  36.738  1.00 28.22 ? 202  DA  B N7    1 
ATOM   4348 C C5    . DA  B 2 1   ? -5.906  75.373  37.878  1.00 27.77 ? 202  DA  B C5    1 
ATOM   4349 C C6    . DA  B 2 1   ? -6.456  76.653  38.070  1.00 28.78 ? 202  DA  B C6    1 
ATOM   4350 N N6    . DA  B 2 1   ? -6.925  77.413  37.078  1.00 29.81 ? 202  DA  B N6    1 
ATOM   4351 N N1    . DA  B 2 1   ? -6.519  77.118  39.338  1.00 30.18 ? 202  DA  B N1    1 
ATOM   4352 C C2    . DA  B 2 1   ? -6.030  76.352  40.328  1.00 31.07 ? 202  DA  B C2    1 
ATOM   4353 N N3    . DA  B 2 1   ? -5.491  75.136  40.261  1.00 28.76 ? 202  DA  B N3    1 
ATOM   4354 C C4    . DA  B 2 1   ? -5.464  74.687  38.993  1.00 27.94 ? 202  DA  B C4    1 
ATOM   4355 P P     . DA  B 2 2   ? -1.432  70.055  40.899  1.00 32.93 ? 203  DA  B P     1 
ATOM   4356 O OP1   . DA  B 2 2   ? -1.239  68.569  40.862  1.00 29.86 ? 203  DA  B OP1   1 
ATOM   4357 O OP2   . DA  B 2 2   ? -0.763  71.084  41.755  1.00 30.97 ? 203  DA  B OP2   1 
ATOM   4358 O "O5'" . DA  B 2 2   ? -1.022  70.594  39.437  1.00 32.86 ? 203  DA  B "O5'" 1 
ATOM   4359 C "C5'" . DA  B 2 2   ? -1.382  69.864  38.266  1.00 31.57 ? 203  DA  B "C5'" 1 
ATOM   4360 C "C4'" . DA  B 2 2   ? -1.084  70.727  37.060  1.00 33.38 ? 203  DA  B "C4'" 1 
ATOM   4361 O "O4'" . DA  B 2 2   ? -1.866  71.949  37.091  1.00 30.38 ? 203  DA  B "O4'" 1 
ATOM   4362 C "C3'" . DA  B 2 2   ? 0.382   71.155  36.945  1.00 31.99 ? 203  DA  B "C3'" 1 
ATOM   4363 O "O3'" . DA  B 2 2   ? 0.813   70.971  35.599  1.00 34.68 ? 203  DA  B "O3'" 1 
ATOM   4364 C "C2'" . DA  B 2 2   ? 0.334   72.639  37.296  1.00 30.55 ? 203  DA  B "C2'" 1 
ATOM   4365 C "C1'" . DA  B 2 2   ? -1.010  73.014  36.692  1.00 29.37 ? 203  DA  B "C1'" 1 
ATOM   4366 N N9    . DA  B 2 2   ? -1.559  74.300  37.130  1.00 29.61 ? 203  DA  B N9    1 
ATOM   4367 C C8    . DA  B 2 2   ? -1.381  75.004  38.299  1.00 28.08 ? 203  DA  B C8    1 
ATOM   4368 N N7    . DA  B 2 2   ? -2.014  76.152  38.322  1.00 27.32 ? 203  DA  B N7    1 
ATOM   4369 C C5    . DA  B 2 2   ? -2.583  76.248  37.064  1.00 29.16 ? 203  DA  B C5    1 
ATOM   4370 C C6    . DA  B 2 2   ? -3.371  77.248  36.468  1.00 27.68 ? 203  DA  B C6    1 
ATOM   4371 N N6    . DA  B 2 2   ? -3.722  78.373  37.087  1.00 29.06 ? 203  DA  B N6    1 
ATOM   4372 N N1    . DA  B 2 2   ? -3.821  77.014  35.220  1.00 27.08 ? 203  DA  B N1    1 
ATOM   4373 C C2    . DA  B 2 2   ? -3.480  75.865  34.626  1.00 31.71 ? 203  DA  B C2    1 
ATOM   4374 N N3    . DA  B 2 2   ? -2.725  74.863  35.076  1.00 27.74 ? 203  DA  B N3    1 
ATOM   4375 C C4    . DA  B 2 2   ? -2.322  75.113  36.325  1.00 27.29 ? 203  DA  B C4    1 
ATOM   4376 P P     . DA  B 2 3   ? 1.376   69.544  35.103  1.00 35.80 ? 204  DA  B P     1 
ATOM   4377 O OP1   . DA  B 2 3   ? 2.083   68.863  36.236  1.00 38.64 ? 204  DA  B OP1   1 
ATOM   4378 O OP2   . DA  B 2 3   ? 2.136   69.798  33.827  1.00 36.80 ? 204  DA  B OP2   1 
ATOM   4379 O "O5'" . DA  B 2 3   ? 0.004   68.778  34.787  1.00 41.29 ? 204  DA  B "O5'" 1 
ATOM   4380 C "C5'" . DA  B 2 3   ? -0.006  67.719  33.814  1.00 41.16 ? 204  DA  B "C5'" 1 
ATOM   4381 C "C4'" . DA  B 2 3   ? -1.427  67.372  33.437  1.00 40.84 ? 204  DA  B "C4'" 1 
ATOM   4382 O "O4'" . DA  B 2 3   ? -2.303  67.541  34.573  1.00 38.07 ? 204  DA  B "O4'" 1 
ATOM   4383 C "C3'" . DA  B 2 3   ? -2.028  68.204  32.304  1.00 38.89 ? 204  DA  B "C3'" 1 
ATOM   4384 O "O3'" . DA  B 2 3   ? -2.527  67.301  31.334  1.00 36.89 ? 204  DA  B "O3'" 1 
ATOM   4385 C "C2'" . DA  B 2 3   ? -3.185  68.950  32.962  1.00 38.06 ? 204  DA  B "C2'" 1 
ATOM   4386 C "C1'" . DA  B 2 3   ? -3.556  68.014  34.102  1.00 35.30 ? 204  DA  B "C1'" 1 
ATOM   4387 N N9    . DA  B 2 3   ? -4.226  68.605  35.259  1.00 32.16 ? 204  DA  B N9    1 
ATOM   4388 C C8    . DA  B 2 3   ? -4.106  69.872  35.770  1.00 32.01 ? 204  DA  B C8    1 
ATOM   4389 N N7    . DA  B 2 3   ? -4.777  70.048  36.881  1.00 30.85 ? 204  DA  B N7    1 
ATOM   4390 C C5    . DA  B 2 3   ? -5.383  68.828  37.122  1.00 31.98 ? 204  DA  B C5    1 
ATOM   4391 C C6    . DA  B 2 3   ? -6.253  68.383  38.139  1.00 31.88 ? 204  DA  B C6    1 
ATOM   4392 N N6    . DA  B 2 3   ? -6.680  69.156  39.134  1.00 33.23 ? 204  DA  B N6    1 
ATOM   4393 N N1    . DA  B 2 3   ? -6.680  67.098  38.079  1.00 33.06 ? 204  DA  B N1    1 
ATOM   4394 C C2    . DA  B 2 3   ? -6.251  66.328  37.072  1.00 32.83 ? 204  DA  B C2    1 
ATOM   4395 N N3    . DA  B 2 3   ? -5.452  66.648  36.055  1.00 32.65 ? 204  DA  B N3    1 
ATOM   4396 C C4    . DA  B 2 3   ? -5.035  67.922  36.140  1.00 31.26 ? 204  DA  B C4    1 
ATOM   4397 P P     . DC  B 2 4   ? -1.651  67.149  29.991  1.00 33.30 ? 205  DC  B P     1 
ATOM   4398 O OP1   . DC  B 2 4   ? -2.345  66.029  29.264  1.00 34.71 ? 205  DC  B OP1   1 
ATOM   4399 O OP2   . DC  B 2 4   ? -0.192  67.214  30.305  1.00 31.78 ? 205  DC  B OP2   1 
ATOM   4400 O "O5'" . DC  B 2 4   ? -2.010  68.537  29.254  1.00 31.70 ? 205  DC  B "O5'" 1 
ATOM   4401 C "C5'" . DC  B 2 4   ? -3.354  68.722  28.749  1.00 31.83 ? 205  DC  B "C5'" 1 
ATOM   4402 C "C4'" . DC  B 2 4   ? -3.459  70.089  28.124  1.00 32.30 ? 205  DC  B "C4'" 1 
ATOM   4403 O "O4'" . DC  B 2 4   ? -3.172  71.085  29.135  1.00 32.70 ? 205  DC  B "O4'" 1 
ATOM   4404 C "C3'" . DC  B 2 4   ? -2.480  70.312  26.975  1.00 31.59 ? 205  DC  B "C3'" 1 
ATOM   4405 O "O3'" . DC  B 2 4   ? -3.172  71.009  25.934  1.00 29.82 ? 205  DC  B "O3'" 1 
ATOM   4406 C "C2'" . DC  B 2 4   ? -1.353  71.090  27.655  1.00 32.34 ? 205  DC  B "C2'" 1 
ATOM   4407 C "C1'" . DC  B 2 4   ? -2.098  71.896  28.711  1.00 32.42 ? 205  DC  B "C1'" 1 
ATOM   4408 N N1    . DC  B 2 4   ? -1.319  72.234  29.929  1.00 32.78 ? 205  DC  B N1    1 
ATOM   4409 C C2    . DC  B 2 4   ? -1.344  73.541  30.422  1.00 31.76 ? 205  DC  B C2    1 
ATOM   4410 O O2    . DC  B 2 4   ? -2.005  74.409  29.824  1.00 31.54 ? 205  DC  B O2    1 
ATOM   4411 N N3    . DC  B 2 4   ? -0.661  73.814  31.558  1.00 32.15 ? 205  DC  B N3    1 
ATOM   4412 C C4    . DC  B 2 4   ? 0.046   72.864  32.183  1.00 32.86 ? 205  DC  B C4    1 
ATOM   4413 N N4    . DC  B 2 4   ? 0.695   73.194  33.284  1.00 29.52 ? 205  DC  B N4    1 
ATOM   4414 C C5    . DC  B 2 4   ? 0.062   71.530  31.705  1.00 31.30 ? 205  DC  B C5    1 
ATOM   4415 C C6    . DC  B 2 4   ? -0.635  71.261  30.598  1.00 33.54 ? 205  DC  B C6    1 
ATOM   4416 P P     . DG  B 2 5   ? -2.426  71.078  24.514  1.00 32.39 ? 206  DG  B P     1 
ATOM   4417 O OP1   . DG  B 2 5   ? -3.417  71.394  23.433  1.00 37.20 ? 206  DG  B OP1   1 
ATOM   4418 O OP2   . DG  B 2 5   ? -1.411  69.998  24.258  1.00 31.96 ? 206  DG  B OP2   1 
ATOM   4419 O "O5'" . DG  B 2 5   ? -1.465  72.365  24.677  1.00 32.29 ? 206  DG  B "O5'" 1 
ATOM   4420 C "C5'" . DG  B 2 5   ? -2.051  73.657  24.875  1.00 30.42 ? 206  DG  B "C5'" 1 
ATOM   4421 C "C4'" . DG  B 2 5   ? -0.947  74.643  25.185  1.00 29.59 ? 206  DG  B "C4'" 1 
ATOM   4422 O "O4'" . DG  B 2 5   ? -0.572  74.489  26.576  1.00 28.63 ? 206  DG  B "O4'" 1 
ATOM   4423 C "C3'" . DG  B 2 5   ? 0.337   74.454  24.366  1.00 29.03 ? 206  DG  B "C3'" 1 
ATOM   4424 O "O3'" . DG  B 2 5   ? 0.905   75.688  23.937  1.00 29.23 ? 206  DG  B "O3'" 1 
ATOM   4425 C "C2'" . DG  B 2 5   ? 1.286   73.849  25.396  1.00 29.31 ? 206  DG  B "C2'" 1 
ATOM   4426 C "C1'" . DG  B 2 5   ? 0.835   74.660  26.598  1.00 27.85 ? 206  DG  B "C1'" 1 
ATOM   4427 N N9    . DG  B 2 5   ? 1.415   74.276  27.879  1.00 26.80 ? 206  DG  B N9    1 
ATOM   4428 C C8    . DG  B 2 5   ? 1.962   73.074  28.256  1.00 26.29 ? 206  DG  B C8    1 
ATOM   4429 N N7    . DG  B 2 5   ? 2.479   73.103  29.454  1.00 25.00 ? 206  DG  B N7    1 
ATOM   4430 C C5    . DG  B 2 5   ? 2.282   74.409  29.879  1.00 25.47 ? 206  DG  B C5    1 
ATOM   4431 C C6    . DG  B 2 5   ? 2.626   75.026  31.105  1.00 25.41 ? 206  DG  B C6    1 
ATOM   4432 O O6    . DG  B 2 5   ? 3.199   74.523  32.083  1.00 27.00 ? 206  DG  B O6    1 
ATOM   4433 N N1    . DG  B 2 5   ? 2.232   76.365  31.130  1.00 23.71 ? 206  DG  B N1    1 
ATOM   4434 C C2    . DG  B 2 5   ? 1.585   77.027  30.114  1.00 23.60 ? 206  DG  B C2    1 
ATOM   4435 N N2    . DG  B 2 5   ? 1.288   78.312  30.331  1.00 22.88 ? 206  DG  B N2    1 
ATOM   4436 N N3    . DG  B 2 5   ? 1.254   76.451  28.961  1.00 23.97 ? 206  DG  B N3    1 
ATOM   4437 C C4    . DG  B 2 5   ? 1.640   75.149  28.911  1.00 24.87 ? 206  DG  B C4    1 
ATOM   4438 P P     . DG  B 2 6   ? 0.368   76.362  22.582  1.00 27.54 ? 207  DG  B P     1 
ATOM   4439 O OP1   . DG  B 2 6   ? -1.123  76.492  22.686  1.00 28.47 ? 207  DG  B OP1   1 
ATOM   4440 O OP2   . DG  B 2 6   ? 1.064   75.745  21.415  1.00 27.26 ? 207  DG  B OP2   1 
ATOM   4441 O "O5'" . DG  B 2 6   ? 0.982   77.842  22.762  1.00 27.71 ? 207  DG  B "O5'" 1 
ATOM   4442 C "C5'" . DG  B 2 6   ? 2.403   78.019  22.995  1.00 24.59 ? 207  DG  B "C5'" 1 
ATOM   4443 C "C4'" . DG  B 2 6   ? 2.575   78.996  24.131  1.00 24.87 ? 207  DG  B "C4'" 1 
ATOM   4444 O "O4'" . DG  B 2 6   ? 2.245   78.351  25.383  1.00 23.16 ? 207  DG  B "O4'" 1 
ATOM   4445 C "C3'" . DG  B 2 6   ? 3.969   79.591  24.327  1.00 25.52 ? 207  DG  B "C3'" 1 
ATOM   4446 O "O3'" . DG  B 2 6   ? 4.113   80.772  23.557  1.00 24.01 ? 207  DG  B "O3'" 1 
ATOM   4447 C "C2'" . DG  B 2 6   ? 3.955   79.959  25.806  1.00 24.20 ? 207  DG  B "C2'" 1 
ATOM   4448 C "C1'" . DG  B 2 6   ? 3.054   78.893  26.424  1.00 25.36 ? 207  DG  B "C1'" 1 
ATOM   4449 N N9    . DG  B 2 6   ? 3.768   77.783  27.072  1.00 25.25 ? 207  DG  B N9    1 
ATOM   4450 C C8    . DG  B 2 6   ? 3.898   76.478  26.669  1.00 25.35 ? 207  DG  B C8    1 
ATOM   4451 N N7    . DG  B 2 6   ? 4.586   75.741  27.509  1.00 27.42 ? 207  DG  B N7    1 
ATOM   4452 C C5    . DG  B 2 6   ? 4.926   76.615  28.532  1.00 26.79 ? 207  DG  B C5    1 
ATOM   4453 C C6    . DG  B 2 6   ? 5.666   76.389  29.721  1.00 25.99 ? 207  DG  B C6    1 
ATOM   4454 O O6    . DG  B 2 6   ? 6.173   75.333  30.136  1.00 25.50 ? 207  DG  B O6    1 
ATOM   4455 N N1    . DG  B 2 6   ? 5.758   77.555  30.477  1.00 25.84 ? 207  DG  B N1    1 
ATOM   4456 C C2    . DG  B 2 6   ? 5.216   78.774  30.149  1.00 25.81 ? 207  DG  B C2    1 
ATOM   4457 N N2    . DG  B 2 6   ? 5.433   79.773  31.012  1.00 26.27 ? 207  DG  B N2    1 
ATOM   4458 N N3    . DG  B 2 6   ? 4.534   78.999  29.027  1.00 24.96 ? 207  DG  B N3    1 
ATOM   4459 C C4    . DG  B 2 6   ? 4.419   77.876  28.276  1.00 25.47 ? 207  DG  B C4    1 
ATOM   4460 P P     . DC  B 2 7   ? 5.477   81.038  22.759  1.00 25.12 ? 208  DC  B P     1 
ATOM   4461 O OP1   . DC  B 2 7   ? 5.217   82.340  22.063  1.00 23.75 ? 208  DC  B OP1   1 
ATOM   4462 O OP2   . DC  B 2 7   ? 5.894   79.779  22.066  1.00 25.05 ? 208  DC  B OP2   1 
ATOM   4463 O "O5'" . DC  B 2 7   ? 6.478   81.225  24.005  1.00 25.54 ? 208  DC  B "O5'" 1 
ATOM   4464 C "C5'" . DC  B 2 7   ? 6.320   82.354  24.909  1.00 25.50 ? 208  DC  B "C5'" 1 
ATOM   4465 C "C4'" . DC  B 2 7   ? 7.443   82.362  25.921  1.00 26.10 ? 208  DC  B "C4'" 1 
ATOM   4466 O "O4'" . DC  B 2 7   ? 7.332   81.172  26.739  1.00 26.39 ? 208  DC  B "O4'" 1 
ATOM   4467 C "C3'" . DC  B 2 7   ? 8.866   82.376  25.336  1.00 25.48 ? 208  DC  B "C3'" 1 
ATOM   4468 O "O3'" . DC  B 2 7   ? 9.645   83.396  25.959  1.00 28.81 ? 208  DC  B "O3'" 1 
ATOM   4469 C "C2'" . DC  B 2 7   ? 9.405   80.994  25.672  1.00 25.58 ? 208  DC  B "C2'" 1 
ATOM   4470 C "C1'" . DC  B 2 7   ? 8.601   80.577  26.888  1.00 24.25 ? 208  DC  B "C1'" 1 
ATOM   4471 N N1    . DC  B 2 7   ? 8.414   79.117  27.001  1.00 26.67 ? 208  DC  B N1    1 
ATOM   4472 C C2    . DC  B 2 7   ? 8.887   78.447  28.139  1.00 26.69 ? 208  DC  B C2    1 
ATOM   4473 O O2    . DC  B 2 7   ? 9.411   79.096  29.060  1.00 24.47 ? 208  DC  B O2    1 
ATOM   4474 N N3    . DC  B 2 7   ? 8.750   77.102  28.204  1.00 24.47 ? 208  DC  B N3    1 
ATOM   4475 C C4    . DC  B 2 7   ? 8.154   76.424  27.223  1.00 25.69 ? 208  DC  B C4    1 
ATOM   4476 N N4    . DC  B 2 7   ? 8.018   75.121  27.386  1.00 26.13 ? 208  DC  B N4    1 
ATOM   4477 C C5    . DC  B 2 7   ? 7.641   77.083  26.072  1.00 25.24 ? 208  DC  B C5    1 
ATOM   4478 C C6    . DC  B 2 7   ? 7.801   78.413  25.999  1.00 26.66 ? 208  DC  B C6    1 
ATOM   4479 P P     . DG  B 2 8   ? 11.169  83.690  25.500  1.00 27.12 ? 209  DG  B P     1 
ATOM   4480 O OP1   . DG  B 2 8   ? 11.334  85.176  25.730  1.00 27.81 ? 209  DG  B OP1   1 
ATOM   4481 O OP2   . DG  B 2 8   ? 11.499  83.078  24.176  1.00 28.81 ? 209  DG  B OP2   1 
ATOM   4482 O "O5'" . DG  B 2 8   ? 11.928  82.832  26.626  1.00 28.90 ? 209  DG  B "O5'" 1 
ATOM   4483 C "C5'" . DG  B 2 8   ? 12.021  83.392  27.958  1.00 31.50 ? 209  DG  B "C5'" 1 
ATOM   4484 C "C4'" . DG  B 2 8   ? 13.086  82.667  28.742  1.00 35.05 ? 209  DG  B "C4'" 1 
ATOM   4485 O "O4'" . DG  B 2 8   ? 12.655  81.314  28.980  1.00 33.74 ? 209  DG  B "O4'" 1 
ATOM   4486 C "C3'" . DG  B 2 8   ? 14.457  82.591  28.051  1.00 37.92 ? 209  DG  B "C3'" 1 
ATOM   4487 O "O3'" . DG  B 2 8   ? 15.447  82.892  29.034  1.00 41.26 ? 209  DG  B "O3'" 1 
ATOM   4488 C "C2'" . DG  B 2 8   ? 14.530  81.153  27.547  1.00 35.00 ? 209  DG  B "C2'" 1 
ATOM   4489 C "C1'" . DG  B 2 8   ? 13.681  80.420  28.576  1.00 34.17 ? 209  DG  B "C1'" 1 
ATOM   4490 N N9    . DG  B 2 8   ? 13.061  79.193  28.091  1.00 31.84 ? 209  DG  B N9    1 
ATOM   4491 C C8    . DG  B 2 8   ? 12.424  78.919  26.910  1.00 34.15 ? 209  DG  B C8    1 
ATOM   4492 N N7    . DG  B 2 8   ? 12.017  77.675  26.822  1.00 35.69 ? 209  DG  B N7    1 
ATOM   4493 C C5    . DG  B 2 8   ? 12.401  77.102  28.030  1.00 32.93 ? 209  DG  B C5    1 
ATOM   4494 C C6    . DG  B 2 8   ? 12.253  75.774  28.502  1.00 32.82 ? 209  DG  B C6    1 
ATOM   4495 O O6    . DG  B 2 8   ? 11.713  74.812  27.935  1.00 31.13 ? 209  DG  B O6    1 
ATOM   4496 N N1    . DG  B 2 8   ? 12.818  75.617  29.772  1.00 32.95 ? 209  DG  B N1    1 
ATOM   4497 C C2    . DG  B 2 8   ? 13.439  76.608  30.492  1.00 32.83 ? 209  DG  B C2    1 
ATOM   4498 N N2    . DG  B 2 8   ? 13.900  76.281  31.704  1.00 34.82 ? 209  DG  B N2    1 
ATOM   4499 N N3    . DG  B 2 8   ? 13.588  77.856  30.049  1.00 34.81 ? 209  DG  B N3    1 
ATOM   4500 C C4    . DG  B 2 8   ? 13.053  78.026  28.813  1.00 34.07 ? 209  DG  B C4    1 
ATOM   4501 P P     . DC  B 2 9   ? 16.949  83.202  28.533  1.00 37.80 ? 210  DC  B P     1 
ATOM   4502 O OP1   . DC  B 2 9   ? 17.177  84.618  28.976  1.00 44.65 ? 210  DC  B OP1   1 
ATOM   4503 O OP2   . DC  B 2 9   ? 17.284  82.648  27.182  1.00 33.73 ? 210  DC  B OP2   1 
ATOM   4504 O "O5'" . DC  B 2 9   ? 17.697  82.213  29.561  1.00 35.68 ? 210  DC  B "O5'" 1 
ATOM   4505 C "C5'" . DC  B 2 9   ? 17.396  82.361  30.965  1.00 35.28 ? 210  DC  B "C5'" 1 
ATOM   4506 C "C4'" . DC  B 2 9   ? 17.943  81.174  31.712  1.00 38.98 ? 210  DC  B "C4'" 1 
ATOM   4507 O "O4'" . DC  B 2 9   ? 17.143  80.015  31.410  1.00 37.60 ? 210  DC  B "O4'" 1 
ATOM   4508 C "C3'" . DC  B 2 9   ? 19.394  80.843  31.368  1.00 39.07 ? 210  DC  B "C3'" 1 
ATOM   4509 O "O3'" . DC  B 2 9   ? 20.185  80.836  32.546  1.00 42.62 ? 210  DC  B "O3'" 1 
ATOM   4510 C "C2'" . DC  B 2 9   ? 19.335  79.462  30.735  1.00 39.89 ? 210  DC  B "C2'" 1 
ATOM   4511 C "C1'" . DC  B 2 9   ? 17.967  78.915  31.099  1.00 40.31 ? 210  DC  B "C1'" 1 
ATOM   4512 N N1    . DC  B 2 9   ? 17.327  78.186  29.975  1.00 37.66 ? 210  DC  B N1    1 
ATOM   4513 C C2    . DC  B 2 9   ? 17.066  76.822  30.112  1.00 35.88 ? 210  DC  B C2    1 
ATOM   4514 O O2    . DC  B 2 9   ? 17.325  76.274  31.194  1.00 34.61 ? 210  DC  B O2    1 
ATOM   4515 N N3    . DC  B 2 9   ? 16.507  76.148  29.073  1.00 30.99 ? 210  DC  B N3    1 
ATOM   4516 C C4    . DC  B 2 9   ? 16.209  76.787  27.938  1.00 31.72 ? 210  DC  B C4    1 
ATOM   4517 N N4    . DC  B 2 9   ? 15.650  76.080  26.968  1.00 31.92 ? 210  DC  B N4    1 
ATOM   4518 C C5    . DC  B 2 9   ? 16.497  78.173  27.771  1.00 33.76 ? 210  DC  B C5    1 
ATOM   4519 C C6    . DC  B 2 9   ? 17.059  78.825  28.801  1.00 34.41 ? 210  DC  B C6    1 
ATOM   4520 P P     . DC  B 2 10  ? 21.764  80.627  32.295  1.00 44.32 ? 211  DC  B P     1 
ATOM   4521 O OP1   . DC  B 2 10  ? 22.423  81.153  33.531  1.00 52.03 ? 211  DC  B OP1   1 
ATOM   4522 O OP2   . DC  B 2 10  ? 22.145  81.141  30.934  1.00 49.08 ? 211  DC  B OP2   1 
ATOM   4523 O "O5'" . DC  B 2 10  ? 21.916  79.029  32.214  1.00 39.70 ? 211  DC  B "O5'" 1 
ATOM   4524 C "C5'" . DC  B 2 10  ? 21.552  78.237  33.373  1.00 38.12 ? 211  DC  B "C5'" 1 
ATOM   4525 C "C4'" . DC  B 2 10  ? 21.673  76.778  33.016  1.00 39.55 ? 211  DC  B "C4'" 1 
ATOM   4526 O "O4'" . DC  B 2 10  ? 20.635  76.426  32.085  1.00 39.91 ? 211  DC  B "O4'" 1 
ATOM   4527 C "C3'" . DC  B 2 10  ? 22.983  76.383  32.336  1.00 42.76 ? 211  DC  B "C3'" 1 
ATOM   4528 O "O3'" . DC  B 2 10  ? 23.878  75.811  33.294  1.00 46.20 ? 211  DC  B "O3'" 1 
ATOM   4529 C "C2'" . DC  B 2 10  ? 22.575  75.318  31.321  1.00 42.73 ? 211  DC  B "C2'" 1 
ATOM   4530 C "C1'" . DC  B 2 10  ? 21.053  75.340  31.282  1.00 41.58 ? 211  DC  B "C1'" 1 
ATOM   4531 N N1    . DC  B 2 10  ? 20.517  75.540  29.911  1.00 39.93 ? 211  DC  B N1    1 
ATOM   4532 C C2    . DC  B 2 10  ? 19.962  74.460  29.212  1.00 38.10 ? 211  DC  B C2    1 
ATOM   4533 O O2    . DC  B 2 10  ? 19.901  73.345  29.749  1.00 36.85 ? 211  DC  B O2    1 
ATOM   4534 N N3    . DC  B 2 10  ? 19.489  74.662  27.958  1.00 37.16 ? 211  DC  B N3    1 
ATOM   4535 C C4    . DC  B 2 10  ? 19.563  75.865  27.389  1.00 38.55 ? 211  DC  B C4    1 
ATOM   4536 N N4    . DC  B 2 10  ? 19.087  75.985  26.162  1.00 39.57 ? 211  DC  B N4    1 
ATOM   4537 C C5    . DC  B 2 10  ? 20.143  76.970  28.070  1.00 39.68 ? 211  DC  B C5    1 
ATOM   4538 C C6    . DC  B 2 10  ? 20.604  76.763  29.314  1.00 39.86 ? 211  DC  B C6    1 
ATOM   4539 P P     . DG  B 2 11  ? 25.398  75.495  32.844  1.00 44.74 ? 212  DG  B P     1 
ATOM   4540 O OP1   . DG  B 2 11  ? 26.179  75.379  34.124  1.00 52.39 ? 212  DG  B OP1   1 
ATOM   4541 O OP2   . DG  B 2 11  ? 25.837  76.435  31.760  1.00 43.01 ? 212  DG  B OP2   1 
ATOM   4542 O "O5'" . DG  B 2 11  ? 25.257  74.027  32.215  1.00 35.02 ? 212  DG  B "O5'" 1 
ATOM   4543 C "C5'" . DG  B 2 11  ? 24.695  73.000  33.035  1.00 36.73 ? 212  DG  B "C5'" 1 
ATOM   4544 C "C4'" . DG  B 2 11  ? 24.733  71.704  32.277  1.00 39.01 ? 212  DG  B "C4'" 1 
ATOM   4545 O "O4'" . DG  B 2 11  ? 23.870  71.803  31.127  1.00 40.38 ? 212  DG  B "O4'" 1 
ATOM   4546 C "C3'" . DG  B 2 11  ? 26.106  71.272  31.755  1.00 41.76 ? 212  DG  B "C3'" 1 
ATOM   4547 O "O3'" . DG  B 2 11  ? 26.129  69.855  31.890  1.00 44.33 ? 212  DG  B "O3'" 1 
ATOM   4548 C "C2'" . DG  B 2 11  ? 26.080  71.720  30.293  1.00 42.86 ? 212  DG  B "C2'" 1 
ATOM   4549 C "C1'" . DG  B 2 11  ? 24.606  71.549  29.934  1.00 42.90 ? 212  DG  B "C1'" 1 
ATOM   4550 N N9    . DG  B 2 11  ? 24.083  72.473  28.927  1.00 42.39 ? 212  DG  B N9    1 
ATOM   4551 C C8    . DG  B 2 11  ? 24.322  73.824  28.844  1.00 43.44 ? 212  DG  B C8    1 
ATOM   4552 N N7    . DG  B 2 11  ? 23.694  74.408  27.855  1.00 40.59 ? 212  DG  B N7    1 
ATOM   4553 C C5    . DG  B 2 11  ? 22.994  73.370  27.250  1.00 42.40 ? 212  DG  B C5    1 
ATOM   4554 C C6    . DG  B 2 11  ? 22.132  73.399  26.129  1.00 40.57 ? 212  DG  B C6    1 
ATOM   4555 O O6    . DG  B 2 11  ? 21.827  74.379  25.438  1.00 43.57 ? 212  DG  B O6    1 
ATOM   4556 N N1    . DG  B 2 11  ? 21.634  72.131  25.830  1.00 37.65 ? 212  DG  B N1    1 
ATOM   4557 C C2    . DG  B 2 11  ? 21.913  70.981  26.533  1.00 38.73 ? 212  DG  B C2    1 
ATOM   4558 N N2    . DG  B 2 11  ? 21.328  69.854  26.104  1.00 36.94 ? 212  DG  B N2    1 
ATOM   4559 N N3    . DG  B 2 11  ? 22.716  70.951  27.600  1.00 38.64 ? 212  DG  B N3    1 
ATOM   4560 C C4    . DG  B 2 11  ? 23.226  72.174  27.894  1.00 40.51 ? 212  DG  B C4    1 
ATOM   4561 P P     . DT  B 2 12  ? 27.486  69.022  31.645  1.00 42.33 ? 213  DT  B P     1 
ATOM   4562 O OP1   . DT  B 2 12  ? 27.421  67.886  32.631  1.00 44.91 ? 213  DT  B OP1   1 
ATOM   4563 O OP2   . DT  B 2 12  ? 28.648  69.950  31.459  1.00 35.44 ? 213  DT  B OP2   1 
ATOM   4564 O "O5'" . DT  B 2 12  ? 27.214  68.349  30.218  1.00 41.55 ? 213  DT  B "O5'" 1 
ATOM   4565 C "C5'" . DT  B 2 12  ? 26.095  67.440  30.081  1.00 43.06 ? 213  DT  B "C5'" 1 
ATOM   4566 C "C4'" . DT  B 2 12  ? 25.855  67.181  28.614  1.00 43.91 ? 213  DT  B "C4'" 1 
ATOM   4567 O "O4'" . DT  B 2 12  ? 25.390  68.378  27.952  1.00 40.45 ? 213  DT  B "O4'" 1 
ATOM   4568 C "C3'" . DT  B 2 12  ? 27.100  66.725  27.849  1.00 44.65 ? 213  DT  B "C3'" 1 
ATOM   4569 O "O3'" . DT  B 2 12  ? 26.877  65.377  27.461  1.00 50.37 ? 213  DT  B "O3'" 1 
ATOM   4570 C "C2'" . DT  B 2 12  ? 27.189  67.642  26.633  1.00 44.98 ? 213  DT  B "C2'" 1 
ATOM   4571 C "C1'" . DT  B 2 12  ? 25.826  68.327  26.601  1.00 42.83 ? 213  DT  B "C1'" 1 
ATOM   4572 N N1    . DT  B 2 12  ? 25.813  69.716  26.098  1.00 37.38 ? 213  DT  B N1    1 
ATOM   4573 C C2    . DT  B 2 12  ? 24.934  70.025  25.078  1.00 37.39 ? 213  DT  B C2    1 
ATOM   4574 O O2    . DT  B 2 12  ? 24.213  69.193  24.549  1.00 38.22 ? 213  DT  B O2    1 
ATOM   4575 N N3    . DT  B 2 12  ? 24.935  71.340  24.695  1.00 35.76 ? 213  DT  B N3    1 
ATOM   4576 C C4    . DT  B 2 12  ? 25.706  72.360  25.215  1.00 39.48 ? 213  DT  B C4    1 
ATOM   4577 O O4    . DT  B 2 12  ? 25.593  73.499  24.758  1.00 41.55 ? 213  DT  B O4    1 
ATOM   4578 C C5    . DT  B 2 12  ? 26.604  71.972  26.284  1.00 38.98 ? 213  DT  B C5    1 
ATOM   4579 C C7    . DT  B 2 12  ? 27.477  73.023  26.916  1.00 38.70 ? 213  DT  B C7    1 
ATOM   4580 C C6    . DT  B 2 12  ? 26.600  70.686  26.678  1.00 37.96 ? 213  DT  B C6    1 
ATOM   4581 P P     . DG  B 2 13  ? 28.206  64.536  27.126  1.00 52.01 ? 214  DG  B P     1 
ATOM   4582 O OP1   . DG  B 2 13  ? 27.997  63.182  27.738  1.00 50.83 ? 214  DG  B OP1   1 
ATOM   4583 O OP2   . DG  B 2 13  ? 29.456  65.355  27.298  1.00 51.50 ? 214  DG  B OP2   1 
ATOM   4584 O "O5'" . DG  B 2 13  ? 28.054  64.406  25.535  1.00 54.42 ? 214  DG  B "O5'" 1 
ATOM   4585 C "C5'" . DG  B 2 13  ? 26.906  63.704  24.992  1.00 54.20 ? 214  DG  B "C5'" 1 
ATOM   4586 C "C4'" . DG  B 2 13  ? 26.791  64.058  23.531  1.00 54.61 ? 214  DG  B "C4'" 1 
ATOM   4587 O "O4'" . DG  B 2 13  ? 26.629  65.486  23.405  1.00 51.53 ? 214  DG  B "O4'" 1 
ATOM   4588 C "C3'" . DG  B 2 13  ? 28.012  63.675  22.696  1.00 55.14 ? 214  DG  B "C3'" 1 
ATOM   4589 O "O3'" . DG  B 2 13  ? 27.544  63.054  21.511  1.00 63.33 ? 214  DG  B "O3'" 1 
ATOM   4590 C "C2'" . DG  B 2 13  ? 28.701  65.009  22.420  1.00 53.28 ? 214  DG  B "C2'" 1 
ATOM   4591 C "C1'" . DG  B 2 13  ? 27.542  65.988  22.436  1.00 52.07 ? 214  DG  B "C1'" 1 
ATOM   4592 N N9    . DG  B 2 13  ? 27.887  67.353  22.821  1.00 48.13 ? 214  DG  B N9    1 
ATOM   4593 C C8    . DG  B 2 13  ? 28.713  67.759  23.839  1.00 46.96 ? 214  DG  B C8    1 
ATOM   4594 N N7    . DG  B 2 13  ? 28.805  69.064  23.944  1.00 48.59 ? 214  DG  B N7    1 
ATOM   4595 C C5    . DG  B 2 13  ? 27.984  69.549  22.933  1.00 46.75 ? 214  DG  B C5    1 
ATOM   4596 C C6    . DG  B 2 13  ? 27.698  70.885  22.553  1.00 46.64 ? 214  DG  B C6    1 
ATOM   4597 O O6    . DG  B 2 13  ? 28.110  71.938  23.057  1.00 46.74 ? 214  DG  B O6    1 
ATOM   4598 N N1    . DG  B 2 13  ? 26.834  70.927  21.460  1.00 47.49 ? 214  DG  B N1    1 
ATOM   4599 C C2    . DG  B 2 13  ? 26.301  69.831  20.827  1.00 50.30 ? 214  DG  B C2    1 
ATOM   4600 N N2    . DG  B 2 13  ? 25.471  70.082  19.807  1.00 54.81 ? 214  DG  B N2    1 
ATOM   4601 N N3    . DG  B 2 13  ? 26.569  68.570  21.175  1.00 49.34 ? 214  DG  B N3    1 
ATOM   4602 C C4    . DG  B 2 13  ? 27.413  68.505  22.233  1.00 48.98 ? 214  DG  B C4    1 
ATOM   4603 P P     . DG  B 2 14  ? 28.673  62.450  20.539  1.00 65.77 ? 215  DG  B P     1 
ATOM   4604 O OP1   . DG  B 2 14  ? 28.165  61.111  20.078  1.00 67.45 ? 215  DG  B OP1   1 
ATOM   4605 O OP2   . DG  B 2 14  ? 30.042  62.537  21.160  1.00 61.85 ? 215  DG  B OP2   1 
ATOM   4606 O "O5'" . DG  B 2 14  ? 28.542  63.509  19.337  1.00 63.59 ? 215  DG  B "O5'" 1 
ATOM   4607 C "C5'" . DG  B 2 14  ? 27.278  63.539  18.624  1.00 61.42 ? 215  DG  B "C5'" 1 
ATOM   4608 C "C4'" . DG  B 2 14  ? 27.288  64.656  17.614  1.00 60.63 ? 215  DG  B "C4'" 1 
ATOM   4609 O "O4'" . DG  B 2 14  ? 27.472  65.909  18.299  1.00 55.88 ? 215  DG  B "O4'" 1 
ATOM   4610 C "C3'" . DG  B 2 14  ? 28.387  64.559  16.556  1.00 61.08 ? 215  DG  B "C3'" 1 
ATOM   4611 O "O3'" . DG  B 2 14  ? 27.794  64.804  15.283  1.00 62.55 ? 215  DG  B "O3'" 1 
ATOM   4612 C "C2'" . DG  B 2 14  ? 29.371  65.655  16.956  1.00 57.43 ? 215  DG  B "C2'" 1 
ATOM   4613 C "C1'" . DG  B 2 14  ? 28.466  66.672  17.624  1.00 55.82 ? 215  DG  B "C1'" 1 
ATOM   4614 N N9    . DG  B 2 14  ? 29.116  67.514  18.623  1.00 49.62 ? 215  DG  B N9    1 
ATOM   4615 C C8    . DG  B 2 14  ? 29.810  67.086  19.726  1.00 46.13 ? 215  DG  B C8    1 
ATOM   4616 N N7    . DG  B 2 14  ? 30.251  68.068  20.470  1.00 46.94 ? 215  DG  B N7    1 
ATOM   4617 C C5    . DG  B 2 14  ? 29.806  69.214  19.822  1.00 47.84 ? 215  DG  B C5    1 
ATOM   4618 C C6    . DG  B 2 14  ? 29.988  70.578  20.157  1.00 47.70 ? 215  DG  B C6    1 
ATOM   4619 O O6    . DG  B 2 14  ? 30.579  71.061  21.131  1.00 47.57 ? 215  DG  B O6    1 
ATOM   4620 N N1    . DG  B 2 14  ? 29.380  71.416  19.224  1.00 47.63 ? 215  DG  B N1    1 
ATOM   4621 C C2    . DG  B 2 14  ? 28.678  71.002  18.120  1.00 47.40 ? 215  DG  B C2    1 
ATOM   4622 N N2    . DG  B 2 14  ? 28.162  71.969  17.349  1.00 47.71 ? 215  DG  B N2    1 
ATOM   4623 N N3    . DG  B 2 14  ? 28.511  69.720  17.792  1.00 48.72 ? 215  DG  B N3    1 
ATOM   4624 C C4    . DG  B 2 14  ? 29.099  68.887  18.685  1.00 47.98 ? 215  DG  B C4    1 
ATOM   4625 P P     . DT  B 2 15  ? 28.728  64.467  14.020  1.00 65.15 ? 216  DT  B P     1 
ATOM   4626 O OP1   . DT  B 2 15  ? 27.831  64.014  12.902  1.00 66.26 ? 216  DT  B OP1   1 
ATOM   4627 O OP2   . DT  B 2 15  ? 29.927  63.651  14.430  1.00 61.25 ? 216  DT  B OP2   1 
ATOM   4628 O "O5'" . DT  B 2 15  ? 29.235  65.942  13.655  1.00 61.99 ? 216  DT  B "O5'" 1 
ATOM   4629 C "C5'" . DT  B 2 15  ? 28.247  66.895  13.215  1.00 60.66 ? 216  DT  B "C5'" 1 
ATOM   4630 C "C4'" . DT  B 2 15  ? 28.951  68.204  12.999  1.00 64.08 ? 216  DT  B "C4'" 1 
ATOM   4631 O "O4'" . DT  B 2 15  ? 29.410  68.718  14.270  1.00 62.37 ? 216  DT  B "O4'" 1 
ATOM   4632 C "C3'" . DT  B 2 15  ? 30.184  68.091  12.100  1.00 65.08 ? 216  DT  B "C3'" 1 
ATOM   4633 O "O3'" . DT  B 2 15  ? 29.979  68.912  10.951  1.00 67.81 ? 216  DT  B "O3'" 1 
ATOM   4634 C "C2'" . DT  B 2 15  ? 31.338  68.573  12.980  1.00 60.97 ? 216  DT  B "C2'" 1 
ATOM   4635 C "C1'" . DT  B 2 15  ? 30.631  69.403  14.042  1.00 57.54 ? 216  DT  B "C1'" 1 
ATOM   4636 N N1    . DT  B 2 15  ? 31.331  69.526  15.341  1.00 50.35 ? 216  DT  B N1    1 
ATOM   4637 C C2    . DT  B 2 15  ? 31.495  70.790  15.880  1.00 47.97 ? 216  DT  B C2    1 
ATOM   4638 O O2    . DT  B 2 15  ? 31.120  71.820  15.333  1.00 50.79 ? 216  DT  B O2    1 
ATOM   4639 N N3    . DT  B 2 15  ? 32.130  70.811  17.091  1.00 47.04 ? 216  DT  B N3    1 
ATOM   4640 C C4    . DT  B 2 15  ? 32.603  69.729  17.807  1.00 45.12 ? 216  DT  B C4    1 
ATOM   4641 O O4    . DT  B 2 15  ? 33.147  69.913  18.887  1.00 46.27 ? 216  DT  B O4    1 
ATOM   4642 C C5    . DT  B 2 15  ? 32.398  68.437  17.194  1.00 48.73 ? 216  DT  B C5    1 
ATOM   4643 C C7    . DT  B 2 15  ? 32.889  67.218  17.917  1.00 49.97 ? 216  DT  B C7    1 
ATOM   4644 C C6    . DT  B 2 15  ? 31.776  68.397  16.005  1.00 49.13 ? 216  DT  B C6    1 
ATOM   4645 P P     . DC  B 2 16  ? 31.114  68.722  9.827   1.00 69.75 ? 217  DC  B P     1 
ATOM   4646 O OP1   . DC  B 2 16  ? 30.488  68.720  8.461   1.00 71.52 ? 217  DC  B OP1   1 
ATOM   4647 O OP2   . DC  B 2 16  ? 32.009  67.566  10.191  1.00 70.62 ? 217  DC  B OP2   1 
ATOM   4648 O "O5'" . DC  B 2 16  ? 31.914  70.103  10.015  1.00 63.95 ? 217  DC  B "O5'" 1 
ATOM   4649 C "C5'" . DC  B 2 16  ? 31.157  71.336  9.994   1.00 63.09 ? 217  DC  B "C5'" 1 
ATOM   4650 C "C4'" . DC  B 2 16  ? 32.035  72.473  10.451  1.00 66.68 ? 217  DC  B "C4'" 1 
ATOM   4651 O "O4'" . DC  B 2 16  ? 32.408  72.288  11.838  1.00 65.74 ? 217  DC  B "O4'" 1 
ATOM   4652 C "C3'" . DC  B 2 16  ? 33.345  72.622  9.672   1.00 65.74 ? 217  DC  B "C3'" 1 
ATOM   4653 O "O3'" . DC  B 2 16  ? 33.651  74.009  9.514   1.00 66.96 ? 217  DC  B "O3'" 1 
ATOM   4654 C "C2'" . DC  B 2 16  ? 34.341  71.942  10.597  1.00 66.74 ? 217  DC  B "C2'" 1 
ATOM   4655 C "C1'" . DC  B 2 16  ? 33.814  72.402  11.944  1.00 63.18 ? 217  DC  B "C1'" 1 
ATOM   4656 N N1    . DC  B 2 16  ? 34.286  71.621  13.114  1.00 55.14 ? 217  DC  B N1    1 
ATOM   4657 C C2    . DC  B 2 16  ? 34.538  72.317  14.296  1.00 47.81 ? 217  DC  B C2    1 
ATOM   4658 O O2    . DC  B 2 16  ? 34.343  73.540  14.319  1.00 50.84 ? 217  DC  B O2    1 
ATOM   4659 N N3    . DC  B 2 16  ? 34.977  71.641  15.378  1.00 45.95 ? 217  DC  B N3    1 
ATOM   4660 C C4    . DC  B 2 16  ? 35.185  70.324  15.320  1.00 45.18 ? 217  DC  B C4    1 
ATOM   4661 N N4    . DC  B 2 16  ? 35.620  69.734  16.423  1.00 45.63 ? 217  DC  B N4    1 
ATOM   4662 C C5    . DC  B 2 16  ? 34.938  69.591  14.123  1.00 48.94 ? 217  DC  B C5    1 
ATOM   4663 C C6    . DC  B 2 16  ? 34.495  70.273  13.053  1.00 51.03 ? 217  DC  B C6    1 
HETATM 4664 P P     . OMG B 2 17  ? 34.936  74.320  8.596   1.00 70.43 ? 218  OMG B P     1 
HETATM 4665 O OP1   . OMG B 2 17  ? 34.645  75.529  7.744   1.00 65.53 ? 218  OMG B OP1   1 
HETATM 4666 O OP2   . OMG B 2 17  ? 35.459  73.048  7.982   1.00 60.02 ? 218  OMG B OP2   1 
HETATM 4667 O "O5'" . OMG B 2 17  ? 35.999  74.815  9.694   1.00 70.77 ? 218  OMG B "O5'" 1 
HETATM 4668 C "C5'" . OMG B 2 17  ? 35.616  75.822  10.672  1.00 67.47 ? 218  OMG B "C5'" 1 
HETATM 4669 C "C4'" . OMG B 2 17  ? 36.782  76.042  11.603  1.00 61.82 ? 218  OMG B "C4'" 1 
HETATM 4670 O "O4'" . OMG B 2 17  ? 36.843  74.932  12.542  1.00 55.88 ? 218  OMG B "O4'" 1 
HETATM 4671 C "C3'" . OMG B 2 17  ? 38.152  76.106  10.904  1.00 60.73 ? 218  OMG B "C3'" 1 
HETATM 4672 O "O3'" . OMG B 2 17  ? 38.962  77.178  11.367  1.00 58.61 ? 218  OMG B "O3'" 1 
HETATM 4673 C "C2'" . OMG B 2 17  ? 38.758  74.731  11.202  1.00 60.73 ? 218  OMG B "C2'" 1 
HETATM 4674 O "O2'" . OMG B 2 17  ? 40.184  74.736  11.239  1.00 64.39 ? 218  OMG B "O2'" 1 
HETATM 4675 C CM2   . OMG B 2 17  ? 40.786  74.360  10.002  1.00 61.60 ? 218  OMG B CM2   1 
HETATM 4676 C "C1'" . OMG B 2 17  ? 38.155  74.427  12.574  1.00 55.57 ? 218  OMG B "C1'" 1 
HETATM 4677 N N9    . OMG B 2 17  ? 38.145  72.993  12.860  1.00 51.45 ? 218  OMG B N9    1 
HETATM 4678 C C8    . OMG B 2 17  ? 37.955  71.969  11.964  1.00 48.69 ? 218  OMG B C8    1 
HETATM 4679 N N7    . OMG B 2 17  ? 38.066  70.776  12.500  1.00 48.67 ? 218  OMG B N7    1 
HETATM 4680 C C5    . OMG B 2 17  ? 38.365  71.030  13.834  1.00 48.49 ? 218  OMG B C5    1 
HETATM 4681 C C6    . OMG B 2 17  ? 38.591  70.129  14.905  1.00 46.61 ? 218  OMG B C6    1 
HETATM 4682 O O6    . OMG B 2 17  ? 38.575  68.893  14.880  1.00 49.88 ? 218  OMG B O6    1 
HETATM 4683 N N1    . OMG B 2 17  ? 38.870  70.804  16.094  1.00 47.49 ? 218  OMG B N1    1 
HETATM 4684 C C2    . OMG B 2 17  ? 38.916  72.170  16.232  1.00 45.42 ? 218  OMG B C2    1 
HETATM 4685 N N2    . OMG B 2 17  ? 39.200  72.641  17.448  1.00 47.03 ? 218  OMG B N2    1 
HETATM 4686 N N3    . OMG B 2 17  ? 38.691  73.024  15.235  1.00 47.74 ? 218  OMG B N3    1 
HETATM 4687 C C4    . OMG B 2 17  ? 38.421  72.388  14.067  1.00 48.99 ? 218  OMG B C4    1 
ATOM   4688 O "O5'" . DG  C 3 1   ? 41.624  76.731  21.887  1.00 56.38 ? 100  DG  C "O5'" 1 
ATOM   4689 C "C5'" . DG  C 3 1   ? 40.358  77.034  22.534  1.00 56.44 ? 100  DG  C "C5'" 1 
ATOM   4690 C "C4'" . DG  C 3 1   ? 39.508  77.853  21.594  1.00 55.66 ? 100  DG  C "C4'" 1 
ATOM   4691 O "O4'" . DG  C 3 1   ? 38.953  76.996  20.572  1.00 53.65 ? 100  DG  C "O4'" 1 
ATOM   4692 C "C3'" . DG  C 3 1   ? 38.301  78.545  22.218  1.00 54.41 ? 100  DG  C "C3'" 1 
ATOM   4693 O "O3'" . DG  C 3 1   ? 37.994  79.636  21.347  1.00 56.99 ? 100  DG  C "O3'" 1 
ATOM   4694 C "C2'" . DG  C 3 1   ? 37.275  77.417  22.181  1.00 51.58 ? 100  DG  C "C2'" 1 
ATOM   4695 C "C1'" . DG  C 3 1   ? 37.556  76.812  20.808  1.00 52.75 ? 100  DG  C "C1'" 1 
ATOM   4696 N N9    . DG  C 3 1   ? 37.262  75.385  20.661  1.00 50.20 ? 100  DG  C N9    1 
ATOM   4697 C C8    . DG  C 3 1   ? 37.414  74.394  21.604  1.00 50.46 ? 100  DG  C C8    1 
ATOM   4698 N N7    . DG  C 3 1   ? 37.090  73.202  21.165  1.00 47.44 ? 100  DG  C N7    1 
ATOM   4699 C C5    . DG  C 3 1   ? 36.694  73.421  19.852  1.00 47.31 ? 100  DG  C C5    1 
ATOM   4700 C C6    . DG  C 3 1   ? 36.231  72.500  18.882  1.00 43.47 ? 100  DG  C C6    1 
ATOM   4701 O O6    . DG  C 3 1   ? 36.089  71.279  18.997  1.00 45.91 ? 100  DG  C O6    1 
ATOM   4702 N N1    . DG  C 3 1   ? 35.940  73.129  17.670  1.00 43.82 ? 100  DG  C N1    1 
ATOM   4703 C C2    . DG  C 3 1   ? 36.077  74.474  17.425  1.00 45.38 ? 100  DG  C C2    1 
ATOM   4704 N N2    . DG  C 3 1   ? 35.751  74.881  16.193  1.00 45.08 ? 100  DG  C N2    1 
ATOM   4705 N N3    . DG  C 3 1   ? 36.516  75.351  18.333  1.00 45.45 ? 100  DG  C N3    1 
ATOM   4706 C C4    . DG  C 3 1   ? 36.801  74.759  19.523  1.00 47.58 ? 100  DG  C C4    1 
ATOM   4707 P P     . DA  C 3 2   ? 36.903  80.744  21.762  1.00 63.77 ? 101  DA  C P     1 
ATOM   4708 O OP1   . DA  C 3 2   ? 37.445  82.109  21.433  1.00 60.17 ? 101  DA  C OP1   1 
ATOM   4709 O OP2   . DA  C 3 2   ? 36.369  80.502  23.155  1.00 68.89 ? 101  DA  C OP2   1 
ATOM   4710 O "O5'" . DA  C 3 2   ? 35.761  80.382  20.689  1.00 66.61 ? 101  DA  C "O5'" 1 
ATOM   4711 C "C5'" . DA  C 3 2   ? 36.105  80.373  19.274  1.00 66.63 ? 101  DA  C "C5'" 1 
ATOM   4712 C "C4'" . DA  C 3 2   ? 34.859  80.160  18.450  1.00 69.09 ? 101  DA  C "C4'" 1 
ATOM   4713 O "O4'" . DA  C 3 2   ? 34.599  78.744  18.328  1.00 68.60 ? 101  DA  C "O4'" 1 
ATOM   4714 C "C3'" . DA  C 3 2   ? 33.581  80.784  19.019  1.00 68.70 ? 101  DA  C "C3'" 1 
ATOM   4715 O "O3'" . DA  C 3 2   ? 32.825  81.268  17.909  1.00 73.78 ? 101  DA  C "O3'" 1 
ATOM   4716 C "C2'" . DA  C 3 2   ? 32.920  79.607  19.733  1.00 64.82 ? 101  DA  C "C2'" 1 
ATOM   4717 C "C1'" . DA  C 3 2   ? 33.284  78.456  18.809  1.00 63.00 ? 101  DA  C "C1'" 1 
ATOM   4718 N N9    . DA  C 3 2   ? 33.318  77.134  19.429  1.00 57.88 ? 101  DA  C N9    1 
ATOM   4719 C C8    . DA  C 3 2   ? 33.684  76.778  20.703  1.00 57.86 ? 101  DA  C C8    1 
ATOM   4720 N N7    . DA  C 3 2   ? 33.638  75.486  20.917  1.00 56.29 ? 101  DA  C N7    1 
ATOM   4721 C C5    . DA  C 3 2   ? 33.210  74.951  19.710  1.00 52.88 ? 101  DA  C C5    1 
ATOM   4722 C C6    . DA  C 3 2   ? 32.960  73.628  19.293  1.00 50.02 ? 101  DA  C C6    1 
ATOM   4723 N N6    . DA  C 3 2   ? 33.098  72.564  20.078  1.00 47.88 ? 101  DA  C N6    1 
ATOM   4724 N N1    . DA  C 3 2   ? 32.563  73.443  18.013  1.00 47.35 ? 101  DA  C N1    1 
ATOM   4725 C C2    . DA  C 3 2   ? 32.416  74.516  17.225  1.00 50.96 ? 101  DA  C C2    1 
ATOM   4726 N N3    . DA  C 3 2   ? 32.611  75.801  17.507  1.00 50.09 ? 101  DA  C N3    1 
ATOM   4727 C C4    . DA  C 3 2   ? 33.017  75.956  18.779  1.00 54.44 ? 101  DA  C C4    1 
ATOM   4728 P P     . DC  C 3 3   ? 31.502  82.157  18.146  1.00 72.64 ? 102  DC  C P     1 
ATOM   4729 O OP1   . DC  C 3 3   ? 31.579  83.242  17.107  1.00 66.67 ? 102  DC  C OP1   1 
ATOM   4730 O OP2   . DC  C 3 3   ? 31.272  82.482  19.604  1.00 62.61 ? 102  DC  C OP2   1 
ATOM   4731 O "O5'" . DC  C 3 3   ? 30.385  81.079  17.719  1.00 62.38 ? 102  DC  C "O5'" 1 
ATOM   4732 C "C5'" . DC  C 3 3   ? 30.515  80.408  16.440  1.00 59.53 ? 102  DC  C "C5'" 1 
ATOM   4733 C "C4'" . DC  C 3 3   ? 29.561  79.243  16.398  1.00 59.82 ? 102  DC  C "C4'" 1 
ATOM   4734 O "O4'" . DC  C 3 3   ? 30.047  78.179  17.241  1.00 58.33 ? 102  DC  C "O4'" 1 
ATOM   4735 C "C3'" . DC  C 3 3   ? 28.138  79.537  16.888  1.00 60.38 ? 102  DC  C "C3'" 1 
ATOM   4736 O "O3'" . DC  C 3 3   ? 27.244  79.510  15.772  1.00 66.76 ? 102  DC  C "O3'" 1 
ATOM   4737 C "C2'" . DC  C 3 3   ? 27.836  78.411  17.877  1.00 58.66 ? 102  DC  C "C2'" 1 
ATOM   4738 C "C1'" . DC  C 3 3   ? 28.926  77.395  17.588  1.00 58.67 ? 102  DC  C "C1'" 1 
ATOM   4739 N N1    . DC  C 3 3   ? 29.310  76.523  18.725  1.00 55.06 ? 102  DC  C N1    1 
ATOM   4740 C C2    . DC  C 3 3   ? 29.232  75.132  18.573  1.00 52.45 ? 102  DC  C C2    1 
ATOM   4741 O O2    . DC  C 3 3   ? 28.827  74.655  17.500  1.00 54.86 ? 102  DC  C O2    1 
ATOM   4742 N N3    . DC  C 3 3   ? 29.603  74.339  19.605  1.00 50.48 ? 102  DC  C N3    1 
ATOM   4743 C C4    . DC  C 3 3   ? 30.039  74.874  20.750  1.00 51.45 ? 102  DC  C C4    1 
ATOM   4744 N N4    . DC  C 3 3   ? 30.389  74.039  21.719  1.00 53.00 ? 102  DC  C N4    1 
ATOM   4745 C C5    . DC  C 3 3   ? 30.118  76.286  20.926  1.00 53.47 ? 102  DC  C C5    1 
ATOM   4746 C C6    . DC  C 3 3   ? 29.751  77.065  19.895  1.00 53.16 ? 102  DC  C C6    1 
ATOM   4747 P P     . DC  C 3 4   ? 25.711  79.912  16.074  1.00 63.08 ? 103  DC  C P     1 
ATOM   4748 O OP1   . DC  C 3 4   ? 25.272  80.688  14.866  1.00 62.90 ? 103  DC  C OP1   1 
ATOM   4749 O OP2   . DC  C 3 4   ? 25.580  80.532  17.442  1.00 61.97 ? 103  DC  C OP2   1 
ATOM   4750 O "O5'" . DC  C 3 4   ? 24.999  78.472  16.171  1.00 55.91 ? 103  DC  C "O5'" 1 
ATOM   4751 C "C5'" . DC  C 3 4   ? 25.246  77.498  15.123  1.00 58.73 ? 103  DC  C "C5'" 1 
ATOM   4752 C "C4'" . DC  C 3 4   ? 24.624  76.177  15.506  1.00 61.57 ? 103  DC  C "C4'" 1 
ATOM   4753 O "O4'" . DC  C 3 4   ? 25.403  75.555  16.550  1.00 64.70 ? 103  DC  C "O4'" 1 
ATOM   4754 C "C3'" . DC  C 3 4   ? 23.188  76.267  16.022  1.00 64.89 ? 103  DC  C "C3'" 1 
ATOM   4755 O "O3'" . DC  C 3 4   ? 22.337  75.611  15.084  1.00 70.47 ? 103  DC  C "O3'" 1 
ATOM   4756 C "C2'" . DC  C 3 4   ? 23.194  75.533  17.359  1.00 65.50 ? 103  DC  C "C2'" 1 
ATOM   4757 C "C1'" . DC  C 3 4   ? 24.555  74.859  17.439  1.00 62.06 ? 103  DC  C "C1'" 1 
ATOM   4758 N N1    . DC  C 3 4   ? 25.186  74.919  18.782  1.00 56.62 ? 103  DC  C N1    1 
ATOM   4759 C C2    . DC  C 3 4   ? 25.504  73.731  19.458  1.00 54.81 ? 103  DC  C C2    1 
ATOM   4760 O O2    . DC  C 3 4   ? 25.239  72.637  18.931  1.00 55.21 ? 103  DC  C O2    1 
ATOM   4761 N N3    . DC  C 3 4   ? 26.098  73.811  20.675  1.00 51.05 ? 103  DC  C N3    1 
ATOM   4762 C C4    . DC  C 3 4   ? 26.367  75.001  21.224  1.00 53.08 ? 103  DC  C C4    1 
ATOM   4763 N N4    . DC  C 3 4   ? 26.936  75.011  22.417  1.00 56.05 ? 103  DC  C N4    1 
ATOM   4764 C C5    . DC  C 3 4   ? 26.042  76.216  20.559  1.00 53.42 ? 103  DC  C C5    1 
ATOM   4765 C C6    . DC  C 3 4   ? 25.463  76.128  19.351  1.00 54.96 ? 103  DC  C C6    1 
ATOM   4766 P P     . DA  C 3 5   ? 20.751  75.693  15.345  1.00 59.22 ? 104  DA  C P     1 
ATOM   4767 O OP1   . DA  C 3 5   ? 20.111  75.932  14.010  1.00 70.38 ? 104  DA  C OP1   1 
ATOM   4768 O OP2   . DA  C 3 5   ? 20.409  76.565  16.522  1.00 60.20 ? 104  DA  C OP2   1 
ATOM   4769 O "O5'" . DA  C 3 5   ? 20.482  74.180  15.797  1.00 52.11 ? 104  DA  C "O5'" 1 
ATOM   4770 C "C5'" . DA  C 3 5   ? 21.061  73.100  15.041  1.00 51.49 ? 104  DA  C "C5'" 1 
ATOM   4771 C "C4'" . DA  C 3 5   ? 20.701  71.801  15.719  1.00 53.52 ? 104  DA  C "C4'" 1 
ATOM   4772 O "O4'" . DA  C 3 5   ? 21.398  71.698  16.980  1.00 52.84 ? 104  DA  C "O4'" 1 
ATOM   4773 C "C3'" . DA  C 3 5   ? 19.219  71.628  16.045  1.00 54.89 ? 104  DA  C "C3'" 1 
ATOM   4774 O "O3'" . DA  C 3 5   ? 18.939  70.240  15.888  1.00 57.70 ? 104  DA  C "O3'" 1 
ATOM   4775 C "C2'" . DA  C 3 5   ? 19.120  72.110  17.493  1.00 53.85 ? 104  DA  C "C2'" 1 
ATOM   4776 C "C1'" . DA  C 3 5   ? 20.474  71.709  18.069  1.00 51.37 ? 104  DA  C "C1'" 1 
ATOM   4777 N N9    . DA  C 3 5   ? 21.049  72.598  19.080  1.00 45.21 ? 104  DA  C N9    1 
ATOM   4778 C C8    . DA  C 3 5   ? 21.050  73.969  19.164  1.00 46.73 ? 104  DA  C C8    1 
ATOM   4779 N N7    . DA  C 3 5   ? 21.728  74.434  20.185  1.00 44.95 ? 104  DA  C N7    1 
ATOM   4780 C C5    . DA  C 3 5   ? 22.213  73.293  20.814  1.00 44.40 ? 104  DA  C C5    1 
ATOM   4781 C C6    . DA  C 3 5   ? 23.012  73.107  21.961  1.00 41.98 ? 104  DA  C C6    1 
ATOM   4782 N N6    . DA  C 3 5   ? 23.483  74.094  22.712  1.00 39.75 ? 104  DA  C N6    1 
ATOM   4783 N N1    . DA  C 3 5   ? 23.297  71.837  22.317  1.00 44.45 ? 104  DA  C N1    1 
ATOM   4784 C C2    . DA  C 3 5   ? 22.836  70.832  21.563  1.00 44.33 ? 104  DA  C C2    1 
ATOM   4785 N N3    . DA  C 3 5   ? 22.091  70.882  20.466  1.00 44.72 ? 104  DA  C N3    1 
ATOM   4786 C C4    . DA  C 3 5   ? 21.812  72.157  20.137  1.00 43.57 ? 104  DA  C C4    1 
ATOM   4787 P P     . DC  C 3 6   ? 17.404  69.790  16.026  1.00 58.78 ? 105  DC  C P     1 
ATOM   4788 O OP1   . DC  C 3 6   ? 17.205  68.597  15.136  1.00 60.97 ? 105  DC  C OP1   1 
ATOM   4789 O OP2   . DC  C 3 6   ? 16.515  71.002  15.988  1.00 51.90 ? 105  DC  C OP2   1 
ATOM   4790 O "O5'" . DC  C 3 6   ? 17.414  69.235  17.535  1.00 55.92 ? 105  DC  C "O5'" 1 
ATOM   4791 C "C5'" . DC  C 3 6   ? 18.294  68.124  17.859  1.00 50.87 ? 105  DC  C "C5'" 1 
ATOM   4792 C "C4'" . DC  C 3 6   ? 18.302  67.913  19.355  1.00 47.15 ? 105  DC  C "C4'" 1 
ATOM   4793 O "O4'" . DC  C 3 6   ? 18.912  69.041  20.011  1.00 47.24 ? 105  DC  C "O4'" 1 
ATOM   4794 C "C3'" . DC  C 3 6   ? 16.922  67.763  19.991  1.00 45.96 ? 105  DC  C "C3'" 1 
ATOM   4795 O "O3'" . DC  C 3 6   ? 16.814  66.424  20.439  1.00 49.13 ? 105  DC  C "O3'" 1 
ATOM   4796 C "C2'" . DC  C 3 6   ? 16.901  68.763  21.146  1.00 44.65 ? 105  DC  C "C2'" 1 
ATOM   4797 C "C1'" . DC  C 3 6   ? 18.362  69.137  21.307  1.00 43.94 ? 105  DC  C "C1'" 1 
ATOM   4798 N N1    . DC  C 3 6   ? 18.645  70.506  21.798  1.00 41.82 ? 105  DC  C N1    1 
ATOM   4799 C C2    . DC  C 3 6   ? 19.455  70.657  22.928  1.00 40.07 ? 105  DC  C C2    1 
ATOM   4800 O O2    . DC  C 3 6   ? 19.850  69.647  23.519  1.00 39.04 ? 105  DC  C O2    1 
ATOM   4801 N N3    . DC  C 3 6   ? 19.751  71.896  23.366  1.00 38.14 ? 105  DC  C N3    1 
ATOM   4802 C C4    . DC  C 3 6   ? 19.306  72.972  22.717  1.00 37.42 ? 105  DC  C C4    1 
ATOM   4803 N N4    . DC  C 3 6   ? 19.653  74.154  23.194  1.00 37.46 ? 105  DC  C N4    1 
ATOM   4804 C C5    . DC  C 3 6   ? 18.488  72.848  21.561  1.00 38.62 ? 105  DC  C C5    1 
ATOM   4805 C C6    . DC  C 3 6   ? 18.202  71.608  21.129  1.00 41.62 ? 105  DC  C C6    1 
ATOM   4806 P P     . DG  C 3 7   ? 15.310  65.975  20.780  1.00 48.96 ? 106  DG  C P     1 
ATOM   4807 O OP1   . DG  C 3 7   ? 15.165  64.539  20.367  1.00 48.92 ? 106  DG  C OP1   1 
ATOM   4808 O OP2   . DG  C 3 7   ? 14.354  67.072  20.399  1.00 50.51 ? 106  DG  C OP2   1 
ATOM   4809 O "O5'" . DG  C 3 7   ? 15.287  66.013  22.390  1.00 47.61 ? 106  DG  C "O5'" 1 
ATOM   4810 C "C5'" . DG  C 3 7   ? 16.312  65.302  23.130  1.00 43.05 ? 106  DG  C "C5'" 1 
ATOM   4811 C "C4'" . DG  C 3 7   ? 16.376  65.838  24.539  1.00 40.73 ? 106  DG  C "C4'" 1 
ATOM   4812 O "O4'" . DG  C 3 7   ? 16.856  67.201  24.525  1.00 37.23 ? 106  DG  C "O4'" 1 
ATOM   4813 C "C3'" . DG  C 3 7   ? 15.050  65.854  25.304  1.00 38.18 ? 106  DG  C "C3'" 1 
ATOM   4814 O "O3'" . DG  C 3 7   ? 15.346  65.262  26.560  1.00 38.06 ? 106  DG  C "O3'" 1 
ATOM   4815 C "C2'" . DG  C 3 7   ? 14.712  67.341  25.405  1.00 36.19 ? 106  DG  C "C2'" 1 
ATOM   4816 C "C1'" . DG  C 3 7   ? 16.100  67.944  25.477  1.00 35.98 ? 106  DG  C "C1'" 1 
ATOM   4817 N N9    . DG  C 3 7   ? 16.195  69.363  25.152  1.00 34.39 ? 106  DG  C N9    1 
ATOM   4818 C C8    . DG  C 3 7   ? 15.562  70.039  24.142  1.00 35.47 ? 106  DG  C C8    1 
ATOM   4819 N N7    . DG  C 3 7   ? 15.849  71.317  24.103  1.00 35.60 ? 106  DG  C N7    1 
ATOM   4820 C C5    . DG  C 3 7   ? 16.743  71.495  25.150  1.00 35.29 ? 106  DG  C C5    1 
ATOM   4821 C C6    . DG  C 3 7   ? 17.406  72.665  25.596  1.00 35.30 ? 106  DG  C C6    1 
ATOM   4822 O O6    . DG  C 3 7   ? 17.323  73.816  25.155  1.00 34.35 ? 106  DG  C O6    1 
ATOM   4823 N N1    . DG  C 3 7   ? 18.216  72.405  26.701  1.00 34.63 ? 106  DG  C N1    1 
ATOM   4824 C C2    . DG  C 3 7   ? 18.381  71.178  27.295  1.00 35.16 ? 106  DG  C C2    1 
ATOM   4825 N N2    . DG  C 3 7   ? 19.198  71.137  28.361  1.00 34.17 ? 106  DG  C N2    1 
ATOM   4826 N N3    . DG  C 3 7   ? 17.767  70.071  26.874  1.00 32.88 ? 106  DG  C N3    1 
ATOM   4827 C C4    . DG  C 3 7   ? 16.971  70.297  25.799  1.00 36.16 ? 106  DG  C C4    1 
ATOM   4828 P P     . DG  C 3 8   ? 14.237  64.958  27.684  1.00 38.32 ? 107  DG  C P     1 
ATOM   4829 O OP1   . DG  C 3 8   ? 14.270  63.495  28.013  1.00 40.12 ? 107  DG  C OP1   1 
ATOM   4830 O OP2   . DG  C 3 8   ? 12.920  65.591  27.357  1.00 41.79 ? 107  DG  C OP2   1 
ATOM   4831 O "O5'" . DG  C 3 8   ? 14.890  65.802  28.887  1.00 40.50 ? 107  DG  C "O5'" 1 
ATOM   4832 C "C5'" . DG  C 3 8   ? 16.190  65.393  29.380  1.00 36.54 ? 107  DG  C "C5'" 1 
ATOM   4833 C "C4'" . DG  C 3 8   ? 16.530  66.146  30.641  1.00 34.42 ? 107  DG  C "C4'" 1 
ATOM   4834 O "O4'" . DG  C 3 8   ? 16.861  67.514  30.328  1.00 32.39 ? 107  DG  C "O4'" 1 
ATOM   4835 C "C3'" . DG  C 3 8   ? 15.440  66.194  31.704  1.00 36.72 ? 107  DG  C "C3'" 1 
ATOM   4836 O "O3'" . DG  C 3 8   ? 16.107  66.181  32.973  1.00 35.12 ? 107  DG  C "O3'" 1 
ATOM   4837 C "C2'" . DG  C 3 8   ? 14.750  67.524  31.410  1.00 34.38 ? 107  DG  C "C2'" 1 
ATOM   4838 C "C1'" . DG  C 3 8   ? 15.906  68.385  30.938  1.00 35.21 ? 107  DG  C "C1'" 1 
ATOM   4839 N N9    . DG  C 3 8   ? 15.515  69.388  29.956  1.00 33.14 ? 107  DG  C N9    1 
ATOM   4840 C C8    . DG  C 3 8   ? 14.819  69.143  28.800  1.00 33.57 ? 107  DG  C C8    1 
ATOM   4841 N N7    . DG  C 3 8   ? 14.616  70.219  28.081  1.00 32.49 ? 107  DG  C N7    1 
ATOM   4842 C C5    . DG  C 3 8   ? 15.222  71.237  28.812  1.00 32.65 ? 107  DG  C C5    1 
ATOM   4843 C C6    . DG  C 3 8   ? 15.304  72.625  28.538  1.00 33.19 ? 107  DG  C C6    1 
ATOM   4844 O O6    . DG  C 3 8   ? 14.853  73.252  27.566  1.00 34.19 ? 107  DG  C O6    1 
ATOM   4845 N N1    . DG  C 3 8   ? 15.990  73.300  29.547  1.00 34.86 ? 107  DG  C N1    1 
ATOM   4846 C C2    . DG  C 3 8   ? 16.531  72.720  30.669  1.00 34.63 ? 107  DG  C C2    1 
ATOM   4847 N N2    . DG  C 3 8   ? 17.161  73.551  31.510  1.00 34.49 ? 107  DG  C N2    1 
ATOM   4848 N N3    . DG  C 3 8   ? 16.450  71.416  30.936  1.00 30.35 ? 107  DG  C N3    1 
ATOM   4849 C C4    . DG  C 3 8   ? 15.780  70.738  29.973  1.00 31.93 ? 107  DG  C C4    1 
ATOM   4850 P P     . DC  C 3 9   ? 15.287  65.901  34.323  1.00 34.76 ? 108  DC  C P     1 
ATOM   4851 O OP1   . DC  C 3 9   ? 16.302  65.429  35.330  1.00 36.13 ? 108  DC  C OP1   1 
ATOM   4852 O OP2   . DC  C 3 9   ? 14.090  65.016  34.130  1.00 33.27 ? 108  DC  C OP2   1 
ATOM   4853 O "O5'" . DC  C 3 9   ? 14.748  67.349  34.762  1.00 32.41 ? 108  DC  C "O5'" 1 
ATOM   4854 C "C5'" . DC  C 3 9   ? 15.699  68.349  35.169  1.00 34.19 ? 108  DC  C "C5'" 1 
ATOM   4855 C "C4'" . DC  C 3 9   ? 15.060  69.717  35.134  1.00 32.91 ? 108  DC  C "C4'" 1 
ATOM   4856 O "O4'" . DC  C 3 9   ? 14.824  70.147  33.775  1.00 31.50 ? 108  DC  C "O4'" 1 
ATOM   4857 C "C3'" . DC  C 3 9   ? 13.714  69.850  35.845  1.00 33.55 ? 108  DC  C "C3'" 1 
ATOM   4858 O "O3'" . DC  C 3 9   ? 13.977  70.498  37.084  1.00 31.12 ? 108  DC  C "O3'" 1 
ATOM   4859 C "C2'" . DC  C 3 9   ? 12.874  70.725  34.912  1.00 32.19 ? 108  DC  C "C2'" 1 
ATOM   4860 C "C1'" . DC  C 3 9   ? 13.865  71.184  33.855  1.00 33.03 ? 108  DC  C "C1'" 1 
ATOM   4861 N N1    . DC  C 3 9   ? 13.267  71.400  32.508  1.00 32.69 ? 108  DC  C N1    1 
ATOM   4862 C C2    . DC  C 3 9   ? 13.350  72.666  31.908  1.00 31.17 ? 108  DC  C C2    1 
ATOM   4863 O O2    . DC  C 3 9   ? 13.913  73.607  32.497  1.00 30.48 ? 108  DC  C O2    1 
ATOM   4864 N N3    . DC  C 3 9   ? 12.826  72.827  30.671  1.00 33.76 ? 108  DC  C N3    1 
ATOM   4865 C C4    . DC  C 3 9   ? 12.199  71.819  30.054  1.00 33.41 ? 108  DC  C C4    1 
ATOM   4866 N N4    . DC  C 3 9   ? 11.710  72.061  28.851  1.00 35.29 ? 108  DC  C N4    1 
ATOM   4867 C C5    . DC  C 3 9   ? 12.118  70.525  30.641  1.00 33.95 ? 108  DC  C C5    1 
ATOM   4868 C C6    . DC  C 3 9   ? 12.647  70.368  31.866  1.00 31.87 ? 108  DC  C C6    1 
ATOM   4869 P P     . DG  C 3 10  ? 12.764  70.682  38.114  1.00 35.43 ? 109  DG  C P     1 
ATOM   4870 O OP1   . DG  C 3 10  ? 13.392  70.995  39.452  1.00 36.99 ? 109  DG  C OP1   1 
ATOM   4871 O OP2   . DG  C 3 10  ? 11.715  69.614  37.949  1.00 28.80 ? 109  DG  C OP2   1 
ATOM   4872 O "O5'" . DG  C 3 10  ? 12.106  72.065  37.602  1.00 34.04 ? 109  DG  C "O5'" 1 
ATOM   4873 C "C5'" . DG  C 3 10  ? 12.901  73.285  37.644  1.00 33.67 ? 109  DG  C "C5'" 1 
ATOM   4874 C "C4'" . DG  C 3 10  ? 12.058  74.470  37.221  1.00 34.41 ? 109  DG  C "C4'" 1 
ATOM   4875 O "O4'" . DG  C 3 10  ? 11.912  74.447  35.778  1.00 32.72 ? 109  DG  C "O4'" 1 
ATOM   4876 C "C3'" . DG  C 3 10  ? 10.637  74.525  37.806  1.00 33.34 ? 109  DG  C "C3'" 1 
ATOM   4877 O "O3'" . DG  C 3 10  ? 10.268  75.882  38.078  1.00 31.29 ? 109  DG  C "O3'" 1 
ATOM   4878 C "C2'" . DG  C 3 10  ? 9.809   73.952  36.662  1.00 31.45 ? 109  DG  C "C2'" 1 
ATOM   4879 C "C1'" . DG  C 3 10  ? 10.527  74.589  35.486  1.00 32.10 ? 109  DG  C "C1'" 1 
ATOM   4880 N N9    . DG  C 3 10  ? 10.196  74.012  34.183  1.00 30.42 ? 109  DG  C N9    1 
ATOM   4881 C C8    . DG  C 3 10  ? 9.879   72.728  33.821  1.00 27.84 ? 109  DG  C C8    1 
ATOM   4882 N N7    . DG  C 3 10  ? 9.588   72.611  32.546  1.00 27.93 ? 109  DG  C N7    1 
ATOM   4883 C C5    . DG  C 3 10  ? 9.692   73.903  32.044  1.00 26.40 ? 109  DG  C C5    1 
ATOM   4884 C C6    . DG  C 3 10  ? 9.419   74.412  30.749  1.00 24.91 ? 109  DG  C C6    1 
ATOM   4885 O O6    . DG  C 3 10  ? 9.068   73.795  29.734  1.00 26.85 ? 109  DG  C O6    1 
ATOM   4886 N N1    . DG  C 3 10  ? 9.635   75.785  30.685  1.00 23.14 ? 109  DG  C N1    1 
ATOM   4887 C C2    . DG  C 3 10  ? 10.018  76.576  31.732  1.00 24.19 ? 109  DG  C C2    1 
ATOM   4888 N N2    . DG  C 3 10  ? 10.182  77.877  31.469  1.00 26.21 ? 109  DG  C N2    1 
ATOM   4889 N N3    . DG  C 3 10  ? 10.262  76.112  32.955  1.00 25.73 ? 109  DG  C N3    1 
ATOM   4890 C C4    . DG  C 3 10  ? 10.066  74.774  33.043  1.00 28.13 ? 109  DG  C C4    1 
ATOM   4891 P P     . DC  C 3 11  ? 9.180   76.137  39.234  1.00 33.32 ? 110  DC  C P     1 
ATOM   4892 O OP1   . DC  C 3 11  ? 9.903   76.294  40.526  1.00 37.30 ? 110  DC  C OP1   1 
ATOM   4893 O OP2   . DC  C 3 11  ? 8.027   75.181  39.123  1.00 32.10 ? 110  DC  C OP2   1 
ATOM   4894 O "O5'" . DC  C 3 11  ? 8.567   77.567  38.823  1.00 30.52 ? 110  DC  C "O5'" 1 
ATOM   4895 C "C5'" . DC  C 3 11  ? 9.407   78.722  38.900  1.00 28.97 ? 110  DC  C "C5'" 1 
ATOM   4896 C "C4'" . DC  C 3 11  ? 8.995   79.723  37.851  1.00 29.12 ? 110  DC  C "C4'" 1 
ATOM   4897 O "O4'" . DC  C 3 11  ? 9.450   79.301  36.544  1.00 30.96 ? 110  DC  C "O4'" 1 
ATOM   4898 C "C3'" . DC  C 3 11  ? 7.493   79.938  37.705  1.00 28.17 ? 110  DC  C "C3'" 1 
ATOM   4899 O "O3'" . DC  C 3 11  ? 7.036   80.857  38.693  1.00 27.59 ? 110  DC  C "O3'" 1 
ATOM   4900 C "C2'" . DC  C 3 11  ? 7.439   80.521  36.305  1.00 26.93 ? 110  DC  C "C2'" 1 
ATOM   4901 C "C1'" . DC  C 3 11  ? 8.496   79.709  35.578  1.00 28.98 ? 110  DC  C "C1'" 1 
ATOM   4902 N N1    . DC  C 3 11  ? 7.958   78.484  34.930  1.00 27.72 ? 110  DC  C N1    1 
ATOM   4903 C C2    . DC  C 3 11  ? 7.529   78.556  33.598  1.00 27.88 ? 110  DC  C C2    1 
ATOM   4904 O O2    . DC  C 3 11  ? 7.615   79.648  33.003  1.00 27.68 ? 110  DC  C O2    1 
ATOM   4905 N N3    . DC  C 3 11  ? 7.041   77.432  33.004  1.00 24.94 ? 110  DC  C N3    1 
ATOM   4906 C C4    . DC  C 3 11  ? 6.998   76.275  33.675  1.00 25.88 ? 110  DC  C C4    1 
ATOM   4907 N N4    . DC  C 3 11  ? 6.525   75.203  33.058  1.00 25.19 ? 110  DC  C N4    1 
ATOM   4908 C C5    . DC  C 3 11  ? 7.413   76.198  35.030  1.00 28.11 ? 110  DC  C C5    1 
ATOM   4909 C C6    . DC  C 3 11  ? 7.893   77.311  35.608  1.00 26.72 ? 110  DC  C C6    1 
ATOM   4910 P P     . DC  C 3 12  ? 5.621   80.595  39.407  1.00 27.38 ? 111  DC  C P     1 
ATOM   4911 O OP1   . DC  C 3 12  ? 5.489   81.550  40.564  1.00 29.21 ? 111  DC  C OP1   1 
ATOM   4912 O OP2   . DC  C 3 12  ? 5.338   79.144  39.645  1.00 26.02 ? 111  DC  C OP2   1 
ATOM   4913 O "O5'" . DC  C 3 12  ? 4.595   81.103  38.271  1.00 26.45 ? 111  DC  C "O5'" 1 
ATOM   4914 C "C5'" . DC  C 3 12  ? 4.741   82.451  37.755  1.00 27.05 ? 111  DC  C "C5'" 1 
ATOM   4915 C "C4'" . DC  C 3 12  ? 3.829   82.656  36.569  1.00 27.46 ? 111  DC  C "C4'" 1 
ATOM   4916 O "O4'" . DC  C 3 12  ? 4.295   81.888  35.427  1.00 25.94 ? 111  DC  C "O4'" 1 
ATOM   4917 C "C3'" . DC  C 3 12  ? 2.379   82.222  36.796  1.00 26.76 ? 111  DC  C "C3'" 1 
ATOM   4918 O "O3'" . DC  C 3 12  ? 1.643   83.320  37.331  1.00 28.78 ? 111  DC  C "O3'" 1 
ATOM   4919 C "C2'" . DC  C 3 12  ? 1.928   81.891  35.383  1.00 25.60 ? 111  DC  C "C2'" 1 
ATOM   4920 C "C1'" . DC  C 3 12  ? 3.187   81.349  34.727  1.00 24.91 ? 111  DC  C "C1'" 1 
ATOM   4921 N N1    . DC  C 3 12  ? 3.295   79.867  34.731  1.00 24.98 ? 111  DC  C N1    1 
ATOM   4922 C C2    . DC  C 3 12  ? 2.885   79.163  33.597  1.00 24.75 ? 111  DC  C C2    1 
ATOM   4923 O O2    . DC  C 3 12  ? 2.375   79.785  32.650  1.00 24.19 ? 111  DC  C O2    1 
ATOM   4924 N N3    . DC  C 3 12  ? 3.030   77.814  33.577  1.00 26.45 ? 111  DC  C N3    1 
ATOM   4925 C C4    . DC  C 3 12  ? 3.535   77.164  34.637  1.00 28.03 ? 111  DC  C C4    1 
ATOM   4926 N N4    . DC  C 3 12  ? 3.632   75.848  34.561  1.00 28.05 ? 111  DC  C N4    1 
ATOM   4927 C C5    . DC  C 3 12  ? 3.958   77.861  35.794  1.00 26.85 ? 111  DC  C C5    1 
ATOM   4928 C C6    . DC  C 3 12  ? 3.826   79.197  35.791  1.00 27.27 ? 111  DC  C C6    1 
HETATM 4929 P P     . OMG C 3 13  ? 0.289   82.988  38.130  1.00 29.30 ? 112  OMG C P     1 
HETATM 4930 O OP1   . OMG C 3 13  ? -0.066  84.286  38.802  1.00 30.89 ? 112  OMG C OP1   1 
HETATM 4931 O OP2   . OMG C 3 13  ? 0.316   81.673  38.852  1.00 29.12 ? 112  OMG C OP2   1 
HETATM 4932 O "O5'" . OMG C 3 13  ? -0.761  82.734  36.952  1.00 27.78 ? 112  OMG C "O5'" 1 
HETATM 4933 C "C5'" . OMG C 3 13  ? -1.049  83.787  36.009  1.00 27.87 ? 112  OMG C "C5'" 1 
HETATM 4934 C "C4'" . OMG C 3 13  ? -2.053  83.217  35.044  1.00 29.39 ? 112  OMG C "C4'" 1 
HETATM 4935 O "O4'" . OMG C 3 13  ? -1.389  82.317  34.119  1.00 27.27 ? 112  OMG C "O4'" 1 
HETATM 4936 C "C3'" . OMG C 3 13  ? -3.125  82.341  35.704  1.00 31.41 ? 112  OMG C "C3'" 1 
HETATM 4937 O "O3'" . OMG C 3 13  ? -4.189  83.161  36.146  1.00 31.58 ? 112  OMG C "O3'" 1 
HETATM 4938 C "C2'" . OMG C 3 13  ? -3.561  81.514  34.525  1.00 33.40 ? 112  OMG C "C2'" 1 
HETATM 4939 O "O2'" . OMG C 3 13  ? -4.350  82.471  33.813  1.00 34.53 ? 112  OMG C "O2'" 1 
HETATM 4940 C CM2   . OMG C 3 13  ? -5.691  82.044  33.587  1.00 36.50 ? 112  OMG C CM2   1 
HETATM 4941 C "C1'" . OMG C 3 13  ? -2.223  81.210  33.846  1.00 30.29 ? 112  OMG C "C1'" 1 
HETATM 4942 N N9    . OMG C 3 13  ? -1.548  79.987  34.298  1.00 29.76 ? 112  OMG C N9    1 
HETATM 4943 C C8    . OMG C 3 13  ? -0.864  79.789  35.475  1.00 28.42 ? 112  OMG C C8    1 
HETATM 4944 N N7    . OMG C 3 13  ? -0.301  78.606  35.565  1.00 27.65 ? 112  OMG C N7    1 
HETATM 4945 C C5    . OMG C 3 13  ? -0.661  77.965  34.386  1.00 28.09 ? 112  OMG C C5    1 
HETATM 4946 C C6    . OMG C 3 13  ? -0.355  76.659  33.923  1.00 27.32 ? 112  OMG C C6    1 
HETATM 4947 O O6    . OMG C 3 13  ? 0.308   75.764  34.471  1.00 27.43 ? 112  OMG C O6    1 
HETATM 4948 N N1    . OMG C 3 13  ? -0.882  76.442  32.662  1.00 27.33 ? 112  OMG C N1    1 
HETATM 4949 C C2    . OMG C 3 13  ? -1.620  77.344  31.937  1.00 28.28 ? 112  OMG C C2    1 
HETATM 4950 N N2    . OMG C 3 13  ? -2.050  76.928  30.744  1.00 28.12 ? 112  OMG C N2    1 
HETATM 4951 N N3    . OMG C 3 13  ? -1.899  78.574  32.354  1.00 26.84 ? 112  OMG C N3    1 
HETATM 4952 C C4    . OMG C 3 13  ? -1.405  78.814  33.590  1.00 27.53 ? 112  OMG C C4    1 
HETATM 4953 P P     . PO4 D 4 .   ? -8.041  82.684  39.282  1.00 57.79 ? 901  PO4 A P     1 
HETATM 4954 O O1    . PO4 D 4 .   ? -8.638  82.644  37.854  1.00 53.16 ? 901  PO4 A O1    1 
HETATM 4955 O O2    . PO4 D 4 .   ? -7.325  84.035  39.487  1.00 59.73 ? 901  PO4 A O2    1 
HETATM 4956 O O3    . PO4 D 4 .   ? -7.036  81.543  39.433  1.00 59.66 ? 901  PO4 A O3    1 
HETATM 4957 O O4    . PO4 D 4 .   ? -9.155  82.518  40.339  1.00 52.21 ? 901  PO4 A O4    1 
HETATM 4958 P P     . PO4 E 4 .   ? -8.909  79.484  45.920  1.00 47.82 ? 902  PO4 A P     1 
HETATM 4959 O O1    . PO4 E 4 .   ? -8.613  79.485  44.434  1.00 52.94 ? 902  PO4 A O1    1 
HETATM 4960 O O2    . PO4 E 4 .   ? -10.406 79.548  46.121  1.00 52.11 ? 902  PO4 A O2    1 
HETATM 4961 O O3    . PO4 E 4 .   ? -8.365  78.207  46.531  1.00 49.76 ? 902  PO4 A O3    1 
HETATM 4962 O O4    . PO4 E 4 .   ? -8.261  80.692  46.579  1.00 53.15 ? 902  PO4 A O4    1 
HETATM 4963 S S     . SO4 F 5 .   ? -13.859 95.592  6.677   1.00 59.35 ? 903  SO4 A S     1 
HETATM 4964 O O1    . SO4 F 5 .   ? -14.235 96.878  6.150   1.00 60.38 ? 903  SO4 A O1    1 
HETATM 4965 O O2    . SO4 F 5 .   ? -14.673 94.551  6.095   1.00 60.73 ? 903  SO4 A O2    1 
HETATM 4966 O O3    . SO4 F 5 .   ? -14.058 95.605  8.106   1.00 58.08 ? 903  SO4 A O3    1 
HETATM 4967 O O4    . SO4 F 5 .   ? -12.486 95.332  6.353   1.00 51.88 ? 903  SO4 A O4    1 
HETATM 4968 S S     . SO4 G 5 .   ? -9.324  56.711  33.599  1.00 94.40 ? 904  SO4 A S     1 
HETATM 4969 O O1    . SO4 G 5 .   ? -8.475  57.807  33.212  1.00 83.01 ? 904  SO4 A O1    1 
HETATM 4970 O O2    . SO4 G 5 .   ? -9.317  55.715  32.556  1.00 94.18 ? 904  SO4 A O2    1 
HETATM 4971 O O3    . SO4 G 5 .   ? -10.664 57.194  33.798  1.00 91.17 ? 904  SO4 A O3    1 
HETATM 4972 O O4    . SO4 G 5 .   ? -8.840  56.125  34.827  1.00 90.22 ? 904  SO4 A O4    1 
HETATM 4973 S S     . SO4 H 5 .   ? 15.599  102.456 39.803  1.00 83.80 ? 905  SO4 A S     1 
HETATM 4974 O O1    . SO4 H 5 .   ? 16.108  103.648 39.168  1.00 76.42 ? 905  SO4 A O1    1 
HETATM 4975 O O2    . SO4 H 5 .   ? 14.704  101.774 38.897  1.00 74.47 ? 905  SO4 A O2    1 
HETATM 4976 O O3    . SO4 H 5 .   ? 16.700  101.585 40.145  1.00 66.74 ? 905  SO4 A O3    1 
HETATM 4977 O O4    . SO4 H 5 .   ? 14.877  102.822 40.998  1.00 75.56 ? 905  SO4 A O4    1 
HETATM 4978 C C1    . PEG I 6 .   ? 15.026  91.102  25.119  1.00 59.15 ? 906  PEG A C1    1 
HETATM 4979 O O1    . PEG I 6 .   ? 15.419  89.758  25.385  1.00 52.79 ? 906  PEG A O1    1 
HETATM 4980 C C2    . PEG I 6 .   ? 15.832  91.743  24.026  1.00 60.75 ? 906  PEG A C2    1 
HETATM 4981 O O2    . PEG I 6 .   ? 16.529  92.884  24.527  1.00 65.04 ? 906  PEG A O2    1 
HETATM 4982 C C3    . PEG I 6 .   ? 17.789  93.110  23.903  1.00 62.36 ? 906  PEG A C3    1 
HETATM 4983 C C4    . PEG I 6 .   ? 18.658  93.951  24.780  1.00 64.46 ? 906  PEG A C4    1 
HETATM 4984 O O4    . PEG I 6 .   ? 19.898  94.241  24.171  1.00 69.59 ? 906  PEG A O4    1 
HETATM 4985 O O     . HOH J 7 .   ? 13.199  84.875  22.486  1.00 39.16 ? 1001 HOH A O     1 
HETATM 4986 O O     . HOH J 7 .   ? -14.451 83.111  41.519  1.00 45.44 ? 1002 HOH A O     1 
HETATM 4987 O O     . HOH J 7 .   ? -13.291 73.167  8.720   1.00 48.50 ? 1003 HOH A O     1 
HETATM 4988 O O     . HOH J 7 .   ? -19.811 95.530  34.430  1.00 50.59 ? 1004 HOH A O     1 
HETATM 4989 O O     . HOH J 7 .   ? 27.494  74.161  41.147  1.00 47.13 ? 1005 HOH A O     1 
HETATM 4990 O O     . HOH J 7 .   ? -2.271  62.683  21.054  1.00 32.51 ? 1006 HOH A O     1 
HETATM 4991 O O     . HOH J 7 .   ? 18.003  78.577  35.265  1.00 52.75 ? 1007 HOH A O     1 
HETATM 4992 O O     . HOH J 7 .   ? 17.603  104.807 7.447   1.00 42.68 ? 1008 HOH A O     1 
HETATM 4993 O O     . HOH J 7 .   ? 29.213  61.245  46.106  1.00 53.88 ? 1009 HOH A O     1 
HETATM 4994 O O     . HOH J 7 .   ? -20.816 89.630  31.534  1.00 43.58 ? 1010 HOH A O     1 
HETATM 4995 O O     . HOH J 7 .   ? 9.922   63.935  36.203  1.00 50.79 ? 1011 HOH A O     1 
HETATM 4996 O O     . HOH J 7 .   ? 16.077  88.572  53.230  1.00 53.74 ? 1012 HOH A O     1 
HETATM 4997 O O     . HOH J 7 .   ? -9.750  78.406  42.495  1.00 35.36 ? 1013 HOH A O     1 
HETATM 4998 O O     . HOH J 7 .   ? -18.890 82.620  43.269  1.00 40.43 ? 1014 HOH A O     1 
HETATM 4999 O O     . HOH J 7 .   ? 7.258   110.076 -5.534  1.00 30.65 ? 1015 HOH A O     1 
HETATM 5000 O O     . HOH J 7 .   ? -24.165 70.158  29.064  1.00 32.71 ? 1016 HOH A O     1 
HETATM 5001 O O     . HOH J 7 .   ? 17.385  102.318 7.921   1.00 40.42 ? 1017 HOH A O     1 
HETATM 5002 O O     . HOH J 7 .   ? -8.414  73.756  51.922  1.00 42.10 ? 1018 HOH A O     1 
HETATM 5003 O O     . HOH J 7 .   ? -16.215 77.518  14.068  1.00 43.58 ? 1019 HOH A O     1 
HETATM 5004 O O     . HOH J 7 .   ? 19.166  90.632  29.887  1.00 44.91 ? 1020 HOH A O     1 
HETATM 5005 O O     . HOH J 7 .   ? -2.369  63.808  18.567  1.00 50.58 ? 1021 HOH A O     1 
HETATM 5006 O O     . HOH J 7 .   ? -12.377 96.169  13.059  1.00 45.70 ? 1022 HOH A O     1 
HETATM 5007 O O     . HOH J 7 .   ? 5.775   85.475  -2.729  1.00 39.31 ? 1023 HOH A O     1 
HETATM 5008 O O     . HOH J 7 .   ? 14.914  88.499  22.992  1.00 43.43 ? 1024 HOH A O     1 
HETATM 5009 O O     . HOH J 7 .   ? -19.756 78.709  49.611  1.00 33.84 ? 1025 HOH A O     1 
HETATM 5010 O O     . HOH J 7 .   ? 18.675  63.370  29.917  1.00 35.67 ? 1026 HOH A O     1 
HETATM 5011 O O     . HOH J 7 .   ? 29.431  77.160  40.695  1.00 54.72 ? 1027 HOH A O     1 
HETATM 5012 O O     . HOH J 7 .   ? -2.026  110.701 31.621  1.00 48.02 ? 1028 HOH A O     1 
HETATM 5013 O O     . HOH J 7 .   ? -10.913 76.649  9.041   1.00 33.25 ? 1029 HOH A O     1 
HETATM 5014 O O     . HOH J 7 .   ? 6.431   92.090  18.788  1.00 29.85 ? 1030 HOH A O     1 
HETATM 5015 O O     . HOH J 7 .   ? 13.554  84.241  4.917   1.00 51.94 ? 1031 HOH A O     1 
HETATM 5016 O O     . HOH J 7 .   ? -12.136 60.224  21.641  1.00 41.41 ? 1032 HOH A O     1 
HETATM 5017 O O     . HOH J 7 .   ? 12.815  100.845 34.432  1.00 41.42 ? 1033 HOH A O     1 
HETATM 5018 O O     . HOH J 7 .   ? 14.502  59.567  39.123  1.00 50.19 ? 1034 HOH A O     1 
HETATM 5019 O O     . HOH J 7 .   ? -16.957 70.294  17.340  1.00 46.23 ? 1035 HOH A O     1 
HETATM 5020 O O     . HOH J 7 .   ? 13.419  59.413  41.899  1.00 58.08 ? 1036 HOH A O     1 
HETATM 5021 O O     . HOH J 7 .   ? -4.298  72.056  10.708  1.00 36.57 ? 1037 HOH A O     1 
HETATM 5022 O O     . HOH J 7 .   ? -4.783  84.654  38.373  1.00 46.54 ? 1038 HOH A O     1 
HETATM 5023 O O     . HOH J 7 .   ? -5.869  76.877  31.209  1.00 38.04 ? 1039 HOH A O     1 
HETATM 5024 O O     . HOH J 7 .   ? -19.672 88.334  10.525  1.00 37.00 ? 1040 HOH A O     1 
HETATM 5025 O O     . HOH J 7 .   ? 17.623  92.450  48.832  1.00 39.68 ? 1041 HOH A O     1 
HETATM 5026 O O     . HOH J 7 .   ? -9.118  108.181 41.480  1.00 44.59 ? 1042 HOH A O     1 
HETATM 5027 O O     . HOH J 7 .   ? -0.000  86.874  38.131  1.00 45.50 ? 1043 HOH A O     1 
HETATM 5028 O O     . HOH J 7 .   ? -8.855  63.631  37.358  1.00 44.73 ? 1044 HOH A O     1 
HETATM 5029 O O     . HOH J 7 .   ? 6.827   79.562  0.684   1.00 41.96 ? 1045 HOH A O     1 
HETATM 5030 O O     . HOH J 7 .   ? -9.771  79.692  14.968  1.00 25.45 ? 1046 HOH A O     1 
HETATM 5031 O O     . HOH J 7 .   ? 6.603   88.391  -2.743  1.00 36.27 ? 1047 HOH A O     1 
HETATM 5032 O O     . HOH J 7 .   ? -17.729 85.250  16.458  1.00 33.68 ? 1048 HOH A O     1 
HETATM 5033 O O     . HOH J 7 .   ? -25.788 74.427  42.932  1.00 59.40 ? 1049 HOH A O     1 
HETATM 5034 O O     . HOH J 7 .   ? -29.273 77.169  37.897  1.00 33.16 ? 1050 HOH A O     1 
HETATM 5035 O O     . HOH J 7 .   ? 3.687   94.213  48.985  1.00 57.90 ? 1051 HOH A O     1 
HETATM 5036 O O     . HOH J 7 .   ? -17.003 103.643 36.401  1.00 53.87 ? 1052 HOH A O     1 
HETATM 5037 O O     . HOH J 7 .   ? -20.129 84.784  41.308  1.00 36.87 ? 1053 HOH A O     1 
HETATM 5038 O O     . HOH J 7 .   ? -3.345  90.504  50.481  1.00 51.53 ? 1054 HOH A O     1 
HETATM 5039 O O     . HOH J 7 .   ? 5.226   100.815 34.925  1.00 30.68 ? 1055 HOH A O     1 
HETATM 5040 O O     . HOH J 7 .   ? -6.169  97.700  14.540  1.00 37.66 ? 1056 HOH A O     1 
HETATM 5041 O O     . HOH J 7 .   ? -15.097 95.198  18.952  1.00 37.05 ? 1057 HOH A O     1 
HETATM 5042 O O     . HOH J 7 .   ? 3.085   75.662  6.009   1.00 46.99 ? 1058 HOH A O     1 
HETATM 5043 O O     . HOH J 7 .   ? 10.899  73.505  48.146  1.00 61.69 ? 1059 HOH A O     1 
HETATM 5044 O O     . HOH J 7 .   ? 7.166   104.056 27.433  1.00 54.38 ? 1060 HOH A O     1 
HETATM 5045 O O     . HOH J 7 .   ? -2.903  66.478  26.053  1.00 34.33 ? 1061 HOH A O     1 
HETATM 5046 O O     . HOH J 7 .   ? 1.303   77.187  18.951  1.00 27.09 ? 1062 HOH A O     1 
HETATM 5047 O O     . HOH J 7 .   ? -8.933  66.912  13.279  1.00 29.09 ? 1063 HOH A O     1 
HETATM 5048 O O     . HOH J 7 .   ? 14.692  87.646  -1.878  1.00 42.86 ? 1064 HOH A O     1 
HETATM 5049 O O     . HOH J 7 .   ? -18.747 95.747  37.386  1.00 57.26 ? 1065 HOH A O     1 
HETATM 5050 O O     . HOH J 7 .   ? 20.807  84.874  32.966  1.00 45.66 ? 1066 HOH A O     1 
HETATM 5051 O O     . HOH J 7 .   ? -25.736 87.008  40.705  1.00 54.58 ? 1067 HOH A O     1 
HETATM 5052 O O     . HOH J 7 .   ? 5.436   89.416  15.761  1.00 37.56 ? 1068 HOH A O     1 
HETATM 5053 O O     . HOH J 7 .   ? -9.713  77.167  1.118   1.00 49.84 ? 1069 HOH A O     1 
HETATM 5054 O O     . HOH J 7 .   ? -5.047  92.173  -1.539  1.00 41.25 ? 1070 HOH A O     1 
HETATM 5055 O O     . HOH J 7 .   ? -19.386 77.725  19.278  1.00 37.26 ? 1071 HOH A O     1 
HETATM 5056 O O     . HOH J 7 .   ? 7.725   94.940  21.684  1.00 37.31 ? 1072 HOH A O     1 
HETATM 5057 O O     . HOH J 7 .   ? -18.541 86.347  3.931   1.00 49.08 ? 1073 HOH A O     1 
HETATM 5058 O O     . HOH J 7 .   ? -3.930  85.174  20.190  1.00 28.51 ? 1074 HOH A O     1 
HETATM 5059 O O     . HOH J 7 .   ? 9.827   109.502 11.151  1.00 61.44 ? 1075 HOH A O     1 
HETATM 5060 O O     . HOH J 7 .   ? 13.143  95.832  26.870  1.00 33.61 ? 1076 HOH A O     1 
HETATM 5061 O O     . HOH J 7 .   ? -18.042 95.884  29.007  1.00 38.39 ? 1077 HOH A O     1 
HETATM 5062 O O     . HOH J 7 .   ? -24.978 63.388  33.090  1.00 52.99 ? 1078 HOH A O     1 
HETATM 5063 O O     . HOH J 7 .   ? -18.685 61.134  23.677  1.00 41.47 ? 1079 HOH A O     1 
HETATM 5064 O O     . HOH J 7 .   ? -25.468 78.255  29.134  1.00 37.36 ? 1080 HOH A O     1 
HETATM 5065 O O     . HOH J 7 .   ? -0.540  92.645  13.323  1.00 23.72 ? 1081 HOH A O     1 
HETATM 5066 O O     . HOH J 7 .   ? 1.002   91.940  -4.560  1.00 37.11 ? 1082 HOH A O     1 
HETATM 5067 O O     . HOH J 7 .   ? -10.195 88.231  -1.789  1.00 42.98 ? 1083 HOH A O     1 
HETATM 5068 O O     . HOH J 7 .   ? -3.769  86.402  -3.820  1.00 47.25 ? 1084 HOH A O     1 
HETATM 5069 O O     . HOH J 7 .   ? -8.959  64.727  34.932  1.00 33.72 ? 1085 HOH A O     1 
HETATM 5070 O O     . HOH J 7 .   ? -17.333 81.216  10.957  1.00 34.50 ? 1086 HOH A O     1 
HETATM 5071 O O     . HOH J 7 .   ? 10.675  102.025 -5.550  1.00 36.34 ? 1087 HOH A O     1 
HETATM 5072 O O     . HOH J 7 .   ? -28.140 81.821  34.019  1.00 40.50 ? 1088 HOH A O     1 
HETATM 5073 O O     . HOH J 7 .   ? -25.421 87.720  32.122  1.00 65.44 ? 1089 HOH A O     1 
HETATM 5074 O O     . HOH J 7 .   ? 26.363  81.869  44.394  1.00 50.22 ? 1090 HOH A O     1 
HETATM 5075 O O     . HOH J 7 .   ? 0.561   89.301  13.428  1.00 27.44 ? 1091 HOH A O     1 
HETATM 5076 O O     . HOH J 7 .   ? -17.489 91.787  41.823  1.00 52.26 ? 1092 HOH A O     1 
HETATM 5077 O O     . HOH J 7 .   ? -23.920 73.412  50.051  1.00 35.88 ? 1093 HOH A O     1 
HETATM 5078 O O     . HOH J 7 .   ? -4.584  89.160  44.133  1.00 36.79 ? 1094 HOH A O     1 
HETATM 5079 O O     . HOH J 7 .   ? -22.341 87.454  32.564  1.00 37.65 ? 1095 HOH A O     1 
HETATM 5080 O O     . HOH J 7 .   ? -16.557 96.100  12.630  1.00 53.08 ? 1096 HOH A O     1 
HETATM 5081 O O     . HOH J 7 .   ? 7.470   85.807  19.193  1.00 38.25 ? 1097 HOH A O     1 
HETATM 5082 O O     . HOH J 7 .   ? 8.630   87.170  50.142  1.00 50.24 ? 1098 HOH A O     1 
HETATM 5083 O O     . HOH J 7 .   ? -24.197 66.019  56.970  1.00 31.58 ? 1099 HOH A O     1 
HETATM 5084 O O     . HOH J 7 .   ? 26.779  63.721  30.388  1.00 48.93 ? 1100 HOH A O     1 
HETATM 5085 O O     . HOH J 7 .   ? 3.084   83.163  27.297  1.00 21.33 ? 1101 HOH A O     1 
HETATM 5086 O O     . HOH J 7 .   ? -16.363 69.016  9.911   1.00 48.78 ? 1102 HOH A O     1 
HETATM 5087 O O     . HOH J 7 .   ? -22.194 58.341  47.355  1.00 55.28 ? 1103 HOH A O     1 
HETATM 5088 O O     . HOH J 7 .   ? -23.995 63.008  55.108  1.00 34.05 ? 1104 HOH A O     1 
HETATM 5089 O O     . HOH J 7 .   ? 3.803   77.247  12.254  1.00 60.97 ? 1105 HOH A O     1 
HETATM 5090 O O     . HOH J 7 .   ? 0.410   99.913  5.285   1.00 32.91 ? 1106 HOH A O     1 
HETATM 5091 O O     . HOH J 7 .   ? -4.991  85.489  41.074  1.00 51.28 ? 1107 HOH A O     1 
HETATM 5092 O O     . HOH J 7 .   ? -2.756  94.182  12.811  1.00 27.98 ? 1108 HOH A O     1 
HETATM 5093 O O     . HOH J 7 .   ? 9.645   90.845  14.271  1.00 38.62 ? 1109 HOH A O     1 
HETATM 5094 O O     . HOH J 7 .   ? 1.081   77.818  8.459   1.00 38.34 ? 1110 HOH A O     1 
HETATM 5095 O O     . HOH J 7 .   ? -8.865  82.430  -1.815  1.00 43.32 ? 1111 HOH A O     1 
HETATM 5096 O O     . HOH J 7 .   ? 13.874  101.012 2.580   1.00 39.53 ? 1112 HOH A O     1 
HETATM 5097 O O     . HOH J 7 .   ? 17.955  91.941  9.319   1.00 48.18 ? 1113 HOH A O     1 
HETATM 5098 O O     . HOH J 7 .   ? 7.349   89.421  50.317  1.00 53.66 ? 1114 HOH A O     1 
HETATM 5099 O O     . HOH J 7 .   ? 21.340  98.621  12.074  1.00 49.46 ? 1115 HOH A O     1 
HETATM 5100 O O     . HOH J 7 .   ? -17.912 90.969  10.933  1.00 45.79 ? 1116 HOH A O     1 
HETATM 5101 O O     . HOH J 7 .   ? -6.300  71.353  45.972  1.00 43.35 ? 1117 HOH A O     1 
HETATM 5102 O O     . HOH J 7 .   ? 12.374  108.110 2.519   1.00 47.27 ? 1118 HOH A O     1 
HETATM 5103 O O     . HOH J 7 .   ? 3.789   87.033  34.832  1.00 23.90 ? 1119 HOH A O     1 
HETATM 5104 O O     . HOH J 7 .   ? -24.332 61.683  35.376  1.00 55.35 ? 1120 HOH A O     1 
HETATM 5105 O O     . HOH J 7 .   ? -13.285 58.745  25.782  1.00 52.13 ? 1121 HOH A O     1 
HETATM 5106 O O     . HOH J 7 .   ? -6.980  107.503 42.863  1.00 41.88 ? 1122 HOH A O     1 
HETATM 5107 O O     . HOH J 7 .   ? -25.836 86.024  35.179  1.00 59.55 ? 1123 HOH A O     1 
HETATM 5108 O O     . HOH J 7 .   ? 8.088   86.669  -2.140  1.00 45.41 ? 1124 HOH A O     1 
HETATM 5109 O O     . HOH J 7 .   ? -9.630  97.476  45.228  1.00 41.60 ? 1125 HOH A O     1 
HETATM 5110 O O     . HOH J 7 .   ? -15.126 80.620  2.009   1.00 63.31 ? 1126 HOH A O     1 
HETATM 5111 O O     . HOH J 7 .   ? 1.798   86.979  13.781  1.00 23.88 ? 1127 HOH A O     1 
HETATM 5112 O O     . HOH J 7 .   ? 13.966  79.403  32.834  1.00 36.57 ? 1128 HOH A O     1 
HETATM 5113 O O     . HOH J 7 .   ? 4.203   96.592  28.420  1.00 28.43 ? 1129 HOH A O     1 
HETATM 5114 O O     . HOH J 7 .   ? -21.679 74.573  24.603  1.00 53.14 ? 1130 HOH A O     1 
HETATM 5115 O O     . HOH J 7 .   ? -7.177  97.110  48.716  1.00 32.51 ? 1131 HOH A O     1 
HETATM 5116 O O     . HOH J 7 .   ? 25.015  78.665  40.485  1.00 53.72 ? 1132 HOH A O     1 
HETATM 5117 O O     . HOH J 7 .   ? -20.654 89.842  35.044  1.00 31.83 ? 1133 HOH A O     1 
HETATM 5118 O O     . HOH J 7 .   ? -2.364  77.983  24.704  1.00 39.40 ? 1134 HOH A O     1 
HETATM 5119 O O     . HOH J 7 .   ? 9.690   86.896  16.495  1.00 47.23 ? 1135 HOH A O     1 
HETATM 5120 O O     . HOH J 7 .   ? 4.701   93.085  6.024   1.00 30.55 ? 1136 HOH A O     1 
HETATM 5121 O O     . HOH J 7 .   ? -0.990  83.952  20.493  1.00 22.07 ? 1137 HOH A O     1 
HETATM 5122 O O     . HOH J 7 .   ? 16.398  100.548 2.842   1.00 39.35 ? 1138 HOH A O     1 
HETATM 5123 O O     . HOH J 7 .   ? -8.036  99.063  19.163  1.00 31.51 ? 1139 HOH A O     1 
HETATM 5124 O O     . HOH J 7 .   ? 19.340  98.797  34.151  1.00 51.16 ? 1140 HOH A O     1 
HETATM 5125 O O     . HOH J 7 .   ? 24.819  54.274  36.248  1.00 54.41 ? 1141 HOH A O     1 
HETATM 5126 O O     . HOH J 7 .   ? 7.833   81.637  42.599  1.00 37.62 ? 1142 HOH A O     1 
HETATM 5127 O O     . HOH J 7 .   ? 14.273  96.631  0.062   1.00 48.77 ? 1143 HOH A O     1 
HETATM 5128 O O     . HOH J 7 .   ? 15.186  56.306  50.634  1.00 53.15 ? 1144 HOH A O     1 
HETATM 5129 O O     . HOH J 7 .   ? -7.236  81.852  28.559  1.00 22.03 ? 1145 HOH A O     1 
HETATM 5130 O O     . HOH J 7 .   ? 6.766   95.210  28.630  1.00 40.66 ? 1146 HOH A O     1 
HETATM 5131 O O     . HOH J 7 .   ? 14.687  94.719  2.110   1.00 37.57 ? 1147 HOH A O     1 
HETATM 5132 O O     . HOH J 7 .   ? -6.458  84.620  28.006  1.00 30.13 ? 1148 HOH A O     1 
HETATM 5133 O O     . HOH J 7 .   ? 4.346   79.298  19.602  1.00 40.72 ? 1149 HOH A O     1 
HETATM 5134 O O     . HOH J 7 .   ? -11.236 72.613  29.891  1.00 28.92 ? 1150 HOH A O     1 
HETATM 5135 O O     . HOH J 7 .   ? 2.772   110.392 1.759   1.00 51.19 ? 1151 HOH A O     1 
HETATM 5136 O O     . HOH J 7 .   ? -6.449  97.810  7.199   1.00 36.80 ? 1152 HOH A O     1 
HETATM 5137 O O     . HOH J 7 .   ? -7.052  62.196  13.434  1.00 44.62 ? 1153 HOH A O     1 
HETATM 5138 O O     . HOH J 7 .   ? 10.343  78.541  48.402  1.00 59.09 ? 1154 HOH A O     1 
HETATM 5139 O O     . HOH J 7 .   ? -14.657 85.828  36.598  1.00 24.23 ? 1155 HOH A O     1 
HETATM 5140 O O     . HOH J 7 .   ? 8.667   87.893  1.170   1.00 29.66 ? 1156 HOH A O     1 
HETATM 5141 O O     . HOH J 7 .   ? -17.568 61.057  48.240  1.00 58.18 ? 1157 HOH A O     1 
HETATM 5142 O O     . HOH J 7 .   ? -4.809  74.557  30.569  1.00 34.07 ? 1158 HOH A O     1 
HETATM 5143 O O     . HOH J 7 .   ? -11.626 100.932 43.866  1.00 50.58 ? 1159 HOH A O     1 
HETATM 5144 O O     . HOH J 7 .   ? -16.407 80.413  43.613  1.00 31.34 ? 1160 HOH A O     1 
HETATM 5145 O O     . HOH J 7 .   ? 10.275  94.719  21.133  1.00 36.06 ? 1161 HOH A O     1 
HETATM 5146 O O     . HOH J 7 .   ? 0.994   74.554  0.189   1.00 45.98 ? 1162 HOH A O     1 
HETATM 5147 O O     . HOH J 7 .   ? -24.235 62.288  30.417  1.00 58.56 ? 1163 HOH A O     1 
HETATM 5148 O O     . HOH J 7 .   ? -0.484  90.875  15.531  1.00 25.76 ? 1164 HOH A O     1 
HETATM 5149 O O     . HOH J 7 .   ? 11.406  81.312  47.718  1.00 40.08 ? 1165 HOH A O     1 
HETATM 5150 O O     . HOH J 7 .   ? 2.427   75.684  14.112  1.00 50.02 ? 1166 HOH A O     1 
HETATM 5151 O O     . HOH J 7 .   ? -9.930  99.282  20.868  1.00 34.70 ? 1167 HOH A O     1 
HETATM 5152 O O     . HOH J 7 .   ? -3.653  104.297 2.958   1.00 50.95 ? 1168 HOH A O     1 
HETATM 5153 O O     . HOH J 7 .   ? -4.345  65.861  18.992  1.00 38.81 ? 1169 HOH A O     1 
HETATM 5154 O O     . HOH J 7 .   ? 1.394   99.971  -12.912 1.00 55.10 ? 1170 HOH A O     1 
HETATM 5155 O O     . HOH J 7 .   ? 7.648   80.979  3.113   1.00 33.58 ? 1171 HOH A O     1 
HETATM 5156 O O     . HOH J 7 .   ? 4.887   89.747  18.475  1.00 28.42 ? 1172 HOH A O     1 
HETATM 5157 O O     . HOH J 7 .   ? 2.361   85.632  17.219  1.00 23.62 ? 1173 HOH A O     1 
HETATM 5158 O O     . HOH J 7 .   ? 13.165  93.298  26.026  1.00 42.57 ? 1174 HOH A O     1 
HETATM 5159 O O     . HOH J 7 .   ? -0.212  60.594  15.849  1.00 53.71 ? 1175 HOH A O     1 
HETATM 5160 O O     . HOH J 7 .   ? -6.671  89.096  42.385  1.00 47.25 ? 1176 HOH A O     1 
HETATM 5161 O O     . HOH J 7 .   ? 17.843  88.350  25.974  1.00 57.31 ? 1177 HOH A O     1 
HETATM 5162 O O     . HOH J 7 .   ? -5.993  73.679  14.516  1.00 28.28 ? 1178 HOH A O     1 
HETATM 5163 O O     . HOH J 7 .   ? -10.855 92.943  44.542  1.00 37.19 ? 1179 HOH A O     1 
HETATM 5164 O O     . HOH J 7 .   ? 7.799   103.921 22.988  1.00 40.64 ? 1180 HOH A O     1 
HETATM 5165 O O     . HOH J 7 .   ? -8.944  79.790  37.720  1.00 37.26 ? 1181 HOH A O     1 
HETATM 5166 O O     . HOH J 7 .   ? 3.987   85.392  13.213  1.00 29.28 ? 1182 HOH A O     1 
HETATM 5167 O O     . HOH J 7 .   ? 12.331  91.702  9.861   1.00 31.49 ? 1183 HOH A O     1 
HETATM 5168 O O     . HOH J 7 .   ? -3.923  85.103  26.772  1.00 22.25 ? 1184 HOH A O     1 
HETATM 5169 O O     . HOH J 7 .   ? -5.842  84.333  43.393  1.00 51.95 ? 1185 HOH A O     1 
HETATM 5170 O O     . HOH J 7 .   ? 3.949   83.414  16.343  1.00 33.18 ? 1186 HOH A O     1 
HETATM 5171 O O     . HOH J 7 .   ? 12.157  64.892  31.131  1.00 37.85 ? 1187 HOH A O     1 
HETATM 5172 O O     . HOH J 7 .   ? -5.414  78.164  43.147  1.00 48.79 ? 1188 HOH A O     1 
HETATM 5173 O O     . HOH J 7 .   ? -7.813  81.110  16.245  1.00 25.85 ? 1189 HOH A O     1 
HETATM 5174 O O     . HOH J 7 .   ? -9.303  85.136  30.799  1.00 32.64 ? 1190 HOH A O     1 
HETATM 5175 O O     . HOH J 7 .   ? 7.266   92.632  6.320   1.00 24.67 ? 1191 HOH A O     1 
HETATM 5176 O O     . HOH J 7 .   ? 17.131  88.892  18.639  1.00 52.78 ? 1192 HOH A O     1 
HETATM 5177 O O     . HOH J 7 .   ? 10.359  97.592  44.569  1.00 49.88 ? 1193 HOH A O     1 
HETATM 5178 O O     . HOH J 7 .   ? 9.148   68.110  38.356  1.00 41.91 ? 1194 HOH A O     1 
HETATM 5179 O O     . HOH J 7 .   ? 0.783   81.599  26.270  1.00 25.81 ? 1195 HOH A O     1 
HETATM 5180 O O     . HOH J 7 .   ? 2.056   110.747 15.008  1.00 55.08 ? 1196 HOH A O     1 
HETATM 5181 O O     . HOH J 7 .   ? -23.819 82.770  24.794  1.00 49.21 ? 1197 HOH A O     1 
HETATM 5182 O O     . HOH J 7 .   ? -5.617  100.730 11.900  1.00 52.43 ? 1198 HOH A O     1 
HETATM 5183 O O     . HOH J 7 .   ? -0.853  76.437  17.272  1.00 26.67 ? 1199 HOH A O     1 
HETATM 5184 O O     . HOH J 7 .   ? -14.458 87.347  3.599   1.00 67.61 ? 1200 HOH A O     1 
HETATM 5185 O O     . HOH J 7 .   ? -1.964  101.065 17.886  1.00 45.00 ? 1201 HOH A O     1 
HETATM 5186 O O     . HOH J 7 .   ? -25.072 84.542  26.006  1.00 50.52 ? 1202 HOH A O     1 
HETATM 5187 O O     . HOH J 7 .   ? -18.496 74.009  24.314  1.00 32.45 ? 1203 HOH A O     1 
HETATM 5188 O O     . HOH J 7 .   ? -7.968  80.266  31.174  1.00 59.92 ? 1204 HOH A O     1 
HETATM 5189 O O     . HOH J 7 .   ? 14.268  89.476  9.013   1.00 44.83 ? 1205 HOH A O     1 
HETATM 5190 O O     . HOH J 7 .   ? -8.835  74.313  49.309  1.00 47.59 ? 1206 HOH A O     1 
HETATM 5191 O O     . HOH J 7 .   ? -10.013 62.067  28.588  1.00 45.96 ? 1207 HOH A O     1 
HETATM 5192 O O     . HOH J 7 .   ? 13.238  85.452  49.756  1.00 43.44 ? 1208 HOH A O     1 
HETATM 5193 O O     . HOH J 7 .   ? -17.606 54.063  47.803  1.00 58.03 ? 1209 HOH A O     1 
HETATM 5194 O O     . HOH J 7 .   ? -10.675 78.571  36.355  1.00 42.86 ? 1210 HOH A O     1 
HETATM 5195 O O     . HOH J 7 .   ? -5.853  91.528  40.903  1.00 35.37 ? 1211 HOH A O     1 
HETATM 5196 O O     . HOH J 7 .   ? 11.552  93.304  23.274  1.00 40.53 ? 1212 HOH A O     1 
HETATM 5197 O O     . HOH J 7 .   ? 1.177   100.334 47.135  1.00 30.76 ? 1213 HOH A O     1 
HETATM 5198 O O     . HOH J 7 .   ? 4.678   110.333 31.388  1.00 55.06 ? 1214 HOH A O     1 
HETATM 5199 O O     . HOH J 7 .   ? -21.796 80.381  50.539  1.00 52.36 ? 1215 HOH A O     1 
HETATM 5200 O O     . HOH J 7 .   ? -3.785  106.876 -3.920  1.00 43.49 ? 1216 HOH A O     1 
HETATM 5201 O O     . HOH J 7 .   ? 2.941   78.741  10.463  1.00 29.22 ? 1217 HOH A O     1 
HETATM 5202 O O     . HOH J 7 .   ? -0.409  79.964  28.302  1.00 22.59 ? 1218 HOH A O     1 
HETATM 5203 O O     . HOH J 7 .   ? 3.740   75.910  41.385  1.00 39.23 ? 1219 HOH A O     1 
HETATM 5204 O O     . HOH J 7 .   ? -4.050  91.173  38.016  1.00 45.49 ? 1220 HOH A O     1 
HETATM 5205 O O     . HOH J 7 .   ? 3.743   78.622  -1.520  1.00 43.93 ? 1221 HOH A O     1 
HETATM 5206 O O     . HOH J 7 .   ? -15.236 96.655  10.708  1.00 55.79 ? 1222 HOH A O     1 
HETATM 5207 O O     . HOH J 7 .   ? -18.660 92.678  12.590  1.00 49.55 ? 1223 HOH A O     1 
HETATM 5208 O O     . HOH J 7 .   ? 20.500  63.254  52.437  1.00 55.57 ? 1224 HOH A O     1 
HETATM 5209 O O     . HOH J 7 .   ? -16.477 72.223  20.578  1.00 31.67 ? 1225 HOH A O     1 
HETATM 5210 O O     . HOH J 7 .   ? 17.515  75.920  38.108  1.00 45.53 ? 1226 HOH A O     1 
HETATM 5211 O O     . HOH J 7 .   ? 1.539   89.447  17.055  1.00 28.22 ? 1227 HOH A O     1 
HETATM 5212 O O     . HOH J 7 .   ? 16.533  88.444  16.067  1.00 41.67 ? 1228 HOH A O     1 
HETATM 5213 O O     . HOH J 7 .   ? 8.883   85.753  11.442  1.00 55.06 ? 1229 HOH A O     1 
HETATM 5214 O O     . HOH J 7 .   ? 11.212  85.354  30.553  1.00 36.34 ? 1230 HOH A O     1 
HETATM 5215 O O     . HOH J 7 .   ? 0.533   83.733  -4.255  1.00 53.13 ? 1231 HOH A O     1 
HETATM 5216 O O     . HOH J 7 .   ? -24.755 73.893  52.681  1.00 36.43 ? 1232 HOH A O     1 
HETATM 5217 O O     . HOH J 7 .   ? 13.203  102.899 36.440  1.00 66.40 ? 1233 HOH A O     1 
HETATM 5218 O O     . HOH J 7 .   ? -20.990 92.477  23.708  1.00 57.85 ? 1234 HOH A O     1 
HETATM 5219 O O     . HOH J 7 .   ? -4.446  102.414 -4.758  1.00 62.53 ? 1235 HOH A O     1 
HETATM 5220 O O     . HOH J 7 .   ? -9.248  74.454  30.198  1.00 35.22 ? 1236 HOH A O     1 
HETATM 5221 O O     . HOH J 7 .   ? -17.298 72.157  23.386  1.00 45.78 ? 1237 HOH A O     1 
HETATM 5222 O O     . HOH J 7 .   ? -13.117 62.044  29.309  1.00 51.64 ? 1238 HOH A O     1 
HETATM 5223 O O     . HOH J 7 .   ? 12.479  86.467  8.996   1.00 61.18 ? 1239 HOH A O     1 
HETATM 5224 O O     . HOH J 7 .   ? -4.101  82.656  39.950  1.00 42.13 ? 1240 HOH A O     1 
HETATM 5225 O O     . HOH J 7 .   ? 22.987  68.007  32.002  1.00 43.34 ? 1241 HOH A O     1 
HETATM 5226 O O     . HOH J 7 .   ? 29.406  63.618  37.761  1.00 63.18 ? 1242 HOH A O     1 
HETATM 5227 O O     . HOH J 7 .   ? -20.187 81.158  10.873  1.00 47.96 ? 1243 HOH A O     1 
HETATM 5228 O O     . HOH J 7 .   ? -4.163  80.447  -4.686  1.00 48.97 ? 1244 HOH A O     1 
HETATM 5229 O O     . HOH J 7 .   ? -8.629  98.064  8.666   1.00 55.88 ? 1245 HOH A O     1 
HETATM 5230 O O     . HOH J 7 .   ? 12.043  103.145 43.959  1.00 55.33 ? 1246 HOH A O     1 
HETATM 5231 O O     . HOH J 7 .   ? 9.013   105.214 34.025  1.00 49.85 ? 1247 HOH A O     1 
HETATM 5232 O O     . HOH J 7 .   ? -20.290 93.588  18.171  1.00 77.59 ? 1248 HOH A O     1 
HETATM 5233 O O     . HOH J 7 .   ? -18.548 94.275  19.770  1.00 59.08 ? 1249 HOH A O     1 
HETATM 5234 O O     . HOH J 7 .   ? -19.412 92.940  21.715  1.00 56.56 ? 1250 HOH A O     1 
HETATM 5235 O O     . HOH J 7 .   ? 17.603  101.103 17.109  1.00 49.08 ? 1251 HOH A O     1 
HETATM 5236 O O     . HOH J 7 .   ? 5.003   102.722 -12.072 1.00 53.98 ? 1252 HOH A O     1 
HETATM 5237 O O     . HOH J 7 .   ? -22.970 91.496  30.745  1.00 55.39 ? 1253 HOH A O     1 
HETATM 5238 O O     . HOH J 7 .   ? -7.903  114.613 37.622  1.00 56.56 ? 1254 HOH A O     1 
HETATM 5239 O O     . HOH J 7 .   ? 17.689  100.765 19.876  1.00 53.12 ? 1255 HOH A O     1 
HETATM 5240 O O     . HOH J 7 .   ? 19.170  90.132  24.848  1.00 59.03 ? 1256 HOH A O     1 
HETATM 5241 O O     . HOH J 7 .   ? -23.522 69.734  26.273  1.00 43.72 ? 1257 HOH A O     1 
HETATM 5242 O O     . HOH J 7 .   ? -3.936  73.181  16.009  1.00 41.49 ? 1258 HOH A O     1 
HETATM 5243 O O     . HOH J 7 .   ? -9.085  60.631  30.590  1.00 58.79 ? 1259 HOH A O     1 
HETATM 5244 O O     . HOH J 7 .   ? -12.606 64.111  11.190  1.00 43.07 ? 1260 HOH A O     1 
HETATM 5245 O O     . HOH J 7 .   ? -18.372 78.981  51.766  1.00 45.20 ? 1261 HOH A O     1 
HETATM 5246 O O     . HOH J 7 .   ? -1.465  73.967  16.698  1.00 36.27 ? 1262 HOH A O     1 
HETATM 5247 O O     . HOH J 7 .   ? -8.969  76.823  31.596  1.00 37.86 ? 1263 HOH A O     1 
HETATM 5248 O O     . HOH J 7 .   ? -25.363 67.882  25.558  1.00 51.24 ? 1264 HOH A O     1 
HETATM 5249 O O     . HOH J 7 .   ? -5.097  91.998  -4.436  1.00 49.50 ? 1265 HOH A O     1 
HETATM 5250 O O     . HOH J 7 .   ? -11.768 78.417  0.469   1.00 62.50 ? 1266 HOH A O     1 
HETATM 5251 O O     . HOH J 7 .   ? -20.380 85.686  16.215  1.00 44.35 ? 1267 HOH A O     1 
HETATM 5252 O O     . HOH J 7 .   ? -23.570 58.592  51.878  1.00 49.13 ? 1268 HOH A O     1 
HETATM 5253 O O     . HOH J 7 .   ? 20.559  91.980  9.271   1.00 69.62 ? 1269 HOH A O     1 
HETATM 5254 O O     . HOH J 7 .   ? -20.457 86.144  18.746  1.00 54.56 ? 1270 HOH A O     1 
HETATM 5255 O O     . HOH J 7 .   ? 6.611   86.129  13.408  1.00 43.15 ? 1271 HOH A O     1 
HETATM 5256 O O     . HOH J 7 .   ? 20.959  93.063  6.998   1.00 53.34 ? 1272 HOH A O     1 
HETATM 5257 O O     . HOH K 7 .   ? 22.127  76.669  25.114  1.00 52.69 ? 301  HOH B O     1 
HETATM 5258 O O     . HOH K 7 .   ? 30.711  73.842  13.802  1.00 59.67 ? 302  HOH B O     1 
HETATM 5259 O O     . HOH K 7 .   ? 0.035   73.446  41.050  1.00 42.27 ? 303  HOH B O     1 
HETATM 5260 O O     . HOH K 7 .   ? 1.080   69.853  23.545  1.00 61.71 ? 304  HOH B O     1 
HETATM 5261 O O     . HOH K 7 .   ? 16.807  76.983  33.649  1.00 46.83 ? 305  HOH B O     1 
HETATM 5262 O O     . HOH K 7 .   ? 8.634   81.178  30.462  1.00 32.75 ? 306  HOH B O     1 
HETATM 5263 O O     . HOH K 7 .   ? 13.632  86.297  26.360  1.00 38.25 ? 307  HOH B O     1 
HETATM 5264 O O     . HOH K 7 .   ? 5.253   73.263  26.902  1.00 35.15 ? 308  HOH B O     1 
HETATM 5265 O O     . HOH K 7 .   ? 6.533   77.324  22.802  1.00 33.99 ? 309  HOH B O     1 
HETATM 5266 O O     . HOH K 7 .   ? 5.997   72.752  29.591  1.00 36.28 ? 310  HOH B O     1 
HETATM 5267 O O     . HOH K 7 .   ? 21.458  83.362  29.673  1.00 50.04 ? 311  HOH B O     1 
HETATM 5268 O O     . HOH K 7 .   ? 3.558   71.951  33.246  1.00 39.51 ? 312  HOH B O     1 
HETATM 5269 O O     . HOH K 7 .   ? 0.212   73.379  20.569  1.00 34.30 ? 313  HOH B O     1 
HETATM 5270 O O     . HOH K 7 .   ? 6.177   83.121  19.712  1.00 38.12 ? 314  HOH B O     1 
HETATM 5271 O O     . HOH K 7 .   ? 3.293   74.360  21.841  1.00 37.31 ? 315  HOH B O     1 
HETATM 5272 O O     . HOH K 7 .   ? -8.034  79.049  40.405  1.00 36.48 ? 316  HOH B O     1 
HETATM 5273 O O     . HOH K 7 .   ? 19.146  78.446  25.079  1.00 49.88 ? 317  HOH B O     1 
HETATM 5274 O O     . HOH K 7 .   ? 3.888   81.606  29.278  1.00 23.84 ? 318  HOH B O     1 
HETATM 5275 O O     . HOH K 7 .   ? 1.588   68.950  29.244  1.00 47.49 ? 319  HOH B O     1 
HETATM 5276 O O     . HOH K 7 .   ? 3.594   70.736  30.147  1.00 40.22 ? 320  HOH B O     1 
HETATM 5277 O O     . HOH K 7 .   ? 11.002  76.150  24.829  1.00 49.51 ? 321  HOH B O     1 
HETATM 5278 O O     . HOH K 7 .   ? 12.346  80.483  23.822  1.00 38.60 ? 322  HOH B O     1 
HETATM 5279 O O     . HOH K 7 .   ? -5.395  78.375  33.400  1.00 24.76 ? 323  HOH B O     1 
HETATM 5280 O O     . HOH K 7 .   ? -2.874  75.776  27.512  1.00 44.85 ? 324  HOH B O     1 
HETATM 5281 O O     . HOH K 7 .   ? -1.978  78.055  40.450  1.00 46.28 ? 325  HOH B O     1 
HETATM 5282 O O     . HOH K 7 .   ? 10.079  82.831  21.671  1.00 47.64 ? 326  HOH B O     1 
HETATM 5283 O O     . HOH K 7 .   ? -7.138  74.838  34.200  1.00 41.80 ? 327  HOH B O     1 
HETATM 5284 O O     . HOH K 7 .   ? -2.981  72.292  33.738  1.00 29.79 ? 328  HOH B O     1 
HETATM 5285 O O     . HOH K 7 .   ? 40.028  75.378  18.002  1.00 47.38 ? 329  HOH B O     1 
HETATM 5286 O O     . HOH K 7 .   ? -8.608  65.370  39.501  1.00 38.38 ? 330  HOH B O     1 
HETATM 5287 O O     . HOH K 7 .   ? 15.238  77.681  24.515  1.00 43.82 ? 331  HOH B O     1 
HETATM 5288 O O     . HOH K 7 .   ? -0.802  71.042  21.514  1.00 52.12 ? 332  HOH B O     1 
HETATM 5289 O O     . HOH K 7 .   ? -1.134  77.503  27.415  1.00 34.37 ? 333  HOH B O     1 
HETATM 5290 O O     . HOH K 7 .   ? 10.960  82.614  31.178  1.00 36.21 ? 334  HOH B O     1 
HETATM 5291 O O     . HOH K 7 .   ? 6.568   73.751  24.912  1.00 36.19 ? 335  HOH B O     1 
HETATM 5292 O O     . HOH K 7 .   ? 9.147   80.038  21.795  1.00 53.82 ? 336  HOH B O     1 
HETATM 5293 O O     . HOH K 7 .   ? 14.937  86.912  29.748  1.00 51.35 ? 337  HOH B O     1 
HETATM 5294 O O     . HOH K 7 .   ? -5.645  73.265  47.552  1.00 54.34 ? 338  HOH B O     1 
HETATM 5295 O O     . HOH K 7 .   ? 4.903   75.504  23.681  1.00 37.19 ? 339  HOH B O     1 
HETATM 5296 O O     . HOH K 7 .   ? 2.768   75.856  17.352  1.00 42.19 ? 340  HOH B O     1 
HETATM 5297 O O     . HOH K 7 .   ? 2.756   71.833  22.799  1.00 41.70 ? 341  HOH B O     1 
HETATM 5298 O O     . HOH K 7 .   ? 14.962  79.893  23.743  1.00 50.37 ? 342  HOH B O     1 
HETATM 5299 O O     . HOH L 7 .   ? 13.528  68.821  21.785  1.00 55.43 ? 201  HOH C O     1 
HETATM 5300 O O     . HOH L 7 .   ? 27.093  80.571  13.151  1.00 64.31 ? 202  HOH C O     1 
HETATM 5301 O O     . HOH L 7 .   ? 11.729  65.575  33.496  1.00 40.27 ? 203  HOH C O     1 
HETATM 5302 O O     . HOH L 7 .   ? 12.729  72.895  41.043  1.00 34.88 ? 204  HOH C O     1 
HETATM 5303 O O     . HOH L 7 .   ? 20.299  67.119  23.723  1.00 54.88 ? 205  HOH C O     1 
HETATM 5304 O O     . HOH L 7 .   ? 43.903  75.997  22.907  1.00 36.90 ? 206  HOH C O     1 
HETATM 5305 O O     . HOH L 7 .   ? 1.972   81.965  31.212  1.00 22.65 ? 207  HOH C O     1 
HETATM 5306 O O     . HOH L 7 .   ? 13.210  73.046  25.484  1.00 40.81 ? 208  HOH C O     1 
HETATM 5307 O O     . HOH L 7 .   ? -2.184  84.314  40.412  1.00 50.74 ? 209  HOH C O     1 
HETATM 5308 O O     . HOH L 7 .   ? 1.339   75.702  36.924  1.00 27.52 ? 210  HOH C O     1 
HETATM 5309 O O     . HOH L 7 .   ? 5.431   76.608  38.739  1.00 29.69 ? 211  HOH C O     1 
HETATM 5310 O O     . HOH L 7 .   ? 11.765  67.119  29.263  1.00 39.77 ? 212  HOH C O     1 
HETATM 5311 O O     . HOH L 7 .   ? 19.320  68.742  30.200  1.00 39.11 ? 213  HOH C O     1 
HETATM 5312 O O     . HOH L 7 .   ? 19.062  76.568  22.010  1.00 42.34 ? 214  HOH C O     1 
HETATM 5313 O O     . HOH L 7 .   ? 8.638   70.716  30.782  1.00 46.04 ? 215  HOH C O     1 
HETATM 5314 O O     . HOH L 7 .   ? 12.658  70.334  26.135  1.00 38.97 ? 216  HOH C O     1 
HETATM 5315 O O     . HOH L 7 .   ? 21.839  68.388  19.289  1.00 52.53 ? 217  HOH C O     1 
HETATM 5316 O O     . HOH L 7 .   ? 14.767  75.250  34.611  1.00 29.54 ? 218  HOH C O     1 
HETATM 5317 O O     . HOH L 7 .   ? 6.494   78.238  42.059  1.00 41.45 ? 219  HOH C O     1 
HETATM 5318 O O     . HOH L 7 .   ? -2.187  80.342  39.016  1.00 41.78 ? 220  HOH C O     1 
HETATM 5319 O O     . HOH L 7 .   ? 18.214  70.391  32.920  1.00 37.63 ? 221  HOH C O     1 
HETATM 5320 O O     . HOH L 7 .   ? 14.200  72.904  22.381  1.00 51.62 ? 222  HOH C O     1 
HETATM 5321 O O     . HOH L 7 .   ? 10.660  69.696  27.561  1.00 46.67 ? 223  HOH C O     1 
HETATM 5322 O O     . HOH L 7 .   ? 4.174   74.821  37.239  1.00 30.93 ? 224  HOH C O     1 
HETATM 5323 O O     . HOH L 7 .   ? 11.084  79.948  33.356  1.00 27.07 ? 225  HOH C O     1 
HETATM 5324 O O     . HOH L 7 .   ? 6.368   72.687  34.580  1.00 35.71 ? 226  HOH C O     1 
HETATM 5325 O O     . HOH L 7 .   ? -5.723  80.732  36.833  1.00 38.77 ? 227  HOH C O     1 
HETATM 5326 O O     . HOH L 7 .   ? 18.965  67.349  26.959  1.00 35.09 ? 228  HOH C O     1 
HETATM 5327 O O     . HOH L 7 .   ? 8.442   71.524  27.787  1.00 39.21 ? 229  HOH C O     1 
HETATM 5328 O O     . HOH L 7 .   ? 9.491   79.298  42.244  1.00 40.75 ? 230  HOH C O     1 
HETATM 5329 O O     . HOH L 7 .   ? 10.880  67.993  33.680  1.00 45.57 ? 231  HOH C O     1 
HETATM 5330 O O     . HOH L 7 .   ? 4.967   77.180  43.500  1.00 47.14 ? 232  HOH C O     1 
# 
